data_8ZLF
# 
_entry.id   8ZLF 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZLF         pdb_00008zlf 10.2210/pdb8zlf/pdb 
WWPDB D_1300048006 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZLF 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              sgourinath@mail.jnu.ac.in 
_pdbx_contact_author.name_first         Samudrala 
_pdbx_contact_author.name_last          Gourinath 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-4090-3063 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Gautam, A.K.'  1 0000-0002-3784-3808 
'Umarao, P.'    2 0009-0004-6117-2321 
'Gourinath, S.' 3 0000-0003-4090-3063 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'crystal structure of DH domain of FYVE domain containing Protein(FP10) from Entamoeba histolytica' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gautam, A.K.'  1 0000-0002-3784-3808 
primary 'Umarao, P.'    2 0009-0004-6117-2321 
primary 'Gourinath, S.' 3 0000-0003-4090-3063 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Rho/RAC guanine nucleotide exchange factor, putative' 24215.014 2  ? ? 
'DH domain of FYVE domain containing GEF(FP10) protein' ? 
2 non-polymer syn 'CITRIC ACID'                                          192.124   1  ? ? ? ? 
3 water       nat water                                                  18.015    78 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;KEDYRERIVNEMFDTEKSYVNSMEICIKGYYEPLIQSGHSVAPADKVNAVFLHFQSVLSINKELLKNMTELKEKGELSTR
LGEAFSQFIPMMNVYKLFLGNSDTSLQFLVELEKSSKFNDILDLLRSHLPGDNQLDLRSYLIMPVQRLPRYKLLLTDLIK
HTDDDFVDKPKLIDALDKISKLATLVNEVIKERSRNQKLLELVDKIEGL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;KEDYRERIVNEMFDTEKSYVNSMEICIKGYYEPLIQSGHSVAPADKVNAVFLHFQSVLSINKELLKNMTELKEKGELSTR
LGEAFSQFIPMMNVYKLFLGNSDTSLQFLVELEKSSKFNDILDLLRSHLPGDNQLDLRSYLIMPVQRLPRYKLLLTDLIK
HTDDDFVDKPKLIDALDKISKLATLVNEVIKERSRNQKLLELVDKIEGL
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CITRIC ACID' CIT 
3 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LYS n 
1 2   GLU n 
1 3   ASP n 
1 4   TYR n 
1 5   ARG n 
1 6   GLU n 
1 7   ARG n 
1 8   ILE n 
1 9   VAL n 
1 10  ASN n 
1 11  GLU n 
1 12  MET n 
1 13  PHE n 
1 14  ASP n 
1 15  THR n 
1 16  GLU n 
1 17  LYS n 
1 18  SER n 
1 19  TYR n 
1 20  VAL n 
1 21  ASN n 
1 22  SER n 
1 23  MET n 
1 24  GLU n 
1 25  ILE n 
1 26  CYS n 
1 27  ILE n 
1 28  LYS n 
1 29  GLY n 
1 30  TYR n 
1 31  TYR n 
1 32  GLU n 
1 33  PRO n 
1 34  LEU n 
1 35  ILE n 
1 36  GLN n 
1 37  SER n 
1 38  GLY n 
1 39  HIS n 
1 40  SER n 
1 41  VAL n 
1 42  ALA n 
1 43  PRO n 
1 44  ALA n 
1 45  ASP n 
1 46  LYS n 
1 47  VAL n 
1 48  ASN n 
1 49  ALA n 
1 50  VAL n 
1 51  PHE n 
1 52  LEU n 
1 53  HIS n 
1 54  PHE n 
1 55  GLN n 
1 56  SER n 
1 57  VAL n 
1 58  LEU n 
1 59  SER n 
1 60  ILE n 
1 61  ASN n 
1 62  LYS n 
1 63  GLU n 
1 64  LEU n 
1 65  LEU n 
1 66  LYS n 
1 67  ASN n 
1 68  MET n 
1 69  THR n 
1 70  GLU n 
1 71  LEU n 
1 72  LYS n 
1 73  GLU n 
1 74  LYS n 
1 75  GLY n 
1 76  GLU n 
1 77  LEU n 
1 78  SER n 
1 79  THR n 
1 80  ARG n 
1 81  LEU n 
1 82  GLY n 
1 83  GLU n 
1 84  ALA n 
1 85  PHE n 
1 86  SER n 
1 87  GLN n 
1 88  PHE n 
1 89  ILE n 
1 90  PRO n 
1 91  MET n 
1 92  MET n 
1 93  ASN n 
1 94  VAL n 
1 95  TYR n 
1 96  LYS n 
1 97  LEU n 
1 98  PHE n 
1 99  LEU n 
1 100 GLY n 
1 101 ASN n 
1 102 SER n 
1 103 ASP n 
1 104 THR n 
1 105 SER n 
1 106 LEU n 
1 107 GLN n 
1 108 PHE n 
1 109 LEU n 
1 110 VAL n 
1 111 GLU n 
1 112 LEU n 
1 113 GLU n 
1 114 LYS n 
1 115 SER n 
1 116 SER n 
1 117 LYS n 
1 118 PHE n 
1 119 ASN n 
1 120 ASP n 
1 121 ILE n 
1 122 LEU n 
1 123 ASP n 
1 124 LEU n 
1 125 LEU n 
1 126 ARG n 
1 127 SER n 
1 128 HIS n 
1 129 LEU n 
1 130 PRO n 
1 131 GLY n 
1 132 ASP n 
1 133 ASN n 
1 134 GLN n 
1 135 LEU n 
1 136 ASP n 
1 137 LEU n 
1 138 ARG n 
1 139 SER n 
1 140 TYR n 
1 141 LEU n 
1 142 ILE n 
1 143 MET n 
1 144 PRO n 
1 145 VAL n 
1 146 GLN n 
1 147 ARG n 
1 148 LEU n 
1 149 PRO n 
1 150 ARG n 
1 151 TYR n 
1 152 LYS n 
1 153 LEU n 
1 154 LEU n 
1 155 LEU n 
1 156 THR n 
1 157 ASP n 
1 158 LEU n 
1 159 ILE n 
1 160 LYS n 
1 161 HIS n 
1 162 THR n 
1 163 ASP n 
1 164 ASP n 
1 165 ASP n 
1 166 PHE n 
1 167 VAL n 
1 168 ASP n 
1 169 LYS n 
1 170 PRO n 
1 171 LYS n 
1 172 LEU n 
1 173 ILE n 
1 174 ASP n 
1 175 ALA n 
1 176 LEU n 
1 177 ASP n 
1 178 LYS n 
1 179 ILE n 
1 180 SER n 
1 181 LYS n 
1 182 LEU n 
1 183 ALA n 
1 184 THR n 
1 185 LEU n 
1 186 VAL n 
1 187 ASN n 
1 188 GLU n 
1 189 VAL n 
1 190 ILE n 
1 191 LYS n 
1 192 GLU n 
1 193 ARG n 
1 194 SER n 
1 195 ARG n 
1 196 ASN n 
1 197 GLN n 
1 198 LYS n 
1 199 LEU n 
1 200 LEU n 
1 201 GLU n 
1 202 LEU n 
1 203 VAL n 
1 204 ASP n 
1 205 LYS n 
1 206 ILE n 
1 207 GLU n 
1 208 GLY n 
1 209 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   209 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 EHI7A_047060 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Entamoeba histolytica HM-1:IMSS-A' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     885318 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CIT non-polymer         . 'CITRIC ACID'   ? 'C6 H8 O7'       192.124 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LYS 1   1   1   LYS LYS A . n 
A 1 2   GLU 2   2   2   GLU GLU A . n 
A 1 3   ASP 3   3   3   ASP ASP A . n 
A 1 4   TYR 4   4   4   TYR TYR A . n 
A 1 5   ARG 5   5   5   ARG ARG A . n 
A 1 6   GLU 6   6   6   GLU GLU A . n 
A 1 7   ARG 7   7   7   ARG ARG A . n 
A 1 8   ILE 8   8   8   ILE ILE A . n 
A 1 9   VAL 9   9   9   VAL VAL A . n 
A 1 10  ASN 10  10  10  ASN ASN A . n 
A 1 11  GLU 11  11  11  GLU GLU A . n 
A 1 12  MET 12  12  12  MET MET A . n 
A 1 13  PHE 13  13  13  PHE PHE A . n 
A 1 14  ASP 14  14  14  ASP ASP A . n 
A 1 15  THR 15  15  15  THR THR A . n 
A 1 16  GLU 16  16  16  GLU GLU A . n 
A 1 17  LYS 17  17  17  LYS LYS A . n 
A 1 18  SER 18  18  18  SER SER A . n 
A 1 19  TYR 19  19  19  TYR TYR A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  ASN 21  21  21  ASN ASN A . n 
A 1 22  SER 22  22  22  SER SER A . n 
A 1 23  MET 23  23  23  MET MET A . n 
A 1 24  GLU 24  24  24  GLU GLU A . n 
A 1 25  ILE 25  25  25  ILE ILE A . n 
A 1 26  CYS 26  26  26  CYS CYS A . n 
A 1 27  ILE 27  27  27  ILE ILE A . n 
A 1 28  LYS 28  28  28  LYS LYS A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  TYR 30  30  30  TYR TYR A . n 
A 1 31  TYR 31  31  31  TYR TYR A . n 
A 1 32  GLU 32  32  32  GLU GLU A . n 
A 1 33  PRO 33  33  33  PRO PRO A . n 
A 1 34  LEU 34  34  34  LEU LEU A . n 
A 1 35  ILE 35  35  35  ILE ILE A . n 
A 1 36  GLN 36  36  36  GLN GLN A . n 
A 1 37  SER 37  37  37  SER SER A . n 
A 1 38  GLY 38  38  38  GLY GLY A . n 
A 1 39  HIS 39  39  39  HIS HIS A . n 
A 1 40  SER 40  40  40  SER SER A . n 
A 1 41  VAL 41  41  41  VAL VAL A . n 
A 1 42  ALA 42  42  42  ALA ALA A . n 
A 1 43  PRO 43  43  43  PRO PRO A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  ASP 45  45  45  ASP ASP A . n 
A 1 46  LYS 46  46  46  LYS LYS A . n 
A 1 47  VAL 47  47  47  VAL VAL A . n 
A 1 48  ASN 48  48  48  ASN ASN A . n 
A 1 49  ALA 49  49  49  ALA ALA A . n 
A 1 50  VAL 50  50  50  VAL VAL A . n 
A 1 51  PHE 51  51  51  PHE PHE A . n 
A 1 52  LEU 52  52  52  LEU LEU A . n 
A 1 53  HIS 53  53  53  HIS HIS A . n 
A 1 54  PHE 54  54  54  PHE PHE A . n 
A 1 55  GLN 55  55  55  GLN GLN A . n 
A 1 56  SER 56  56  56  SER SER A . n 
A 1 57  VAL 57  57  57  VAL VAL A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  SER 59  59  59  SER SER A . n 
A 1 60  ILE 60  60  60  ILE ILE A . n 
A 1 61  ASN 61  61  61  ASN ASN A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  GLU 63  63  63  GLU GLU A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  LEU 65  65  65  LEU LEU A . n 
A 1 66  LYS 66  66  66  LYS LYS A . n 
A 1 67  ASN 67  67  67  ASN ASN A . n 
A 1 68  MET 68  68  68  MET MET A . n 
A 1 69  THR 69  69  69  THR THR A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  LEU 71  71  71  LEU LEU A . n 
A 1 72  LYS 72  72  72  LYS LYS A . n 
A 1 73  GLU 73  73  73  GLU GLU A . n 
A 1 74  LYS 74  74  74  LYS LYS A . n 
A 1 75  GLY 75  75  75  GLY GLY A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  LEU 77  77  77  LEU LEU A . n 
A 1 78  SER 78  78  78  SER SER A . n 
A 1 79  THR 79  79  79  THR THR A . n 
A 1 80  ARG 80  80  80  ARG ARG A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  GLY 82  82  82  GLY GLY A . n 
A 1 83  GLU 83  83  83  GLU GLU A . n 
A 1 84  ALA 84  84  84  ALA ALA A . n 
A 1 85  PHE 85  85  85  PHE PHE A . n 
A 1 86  SER 86  86  86  SER SER A . n 
A 1 87  GLN 87  87  87  GLN GLN A . n 
A 1 88  PHE 88  88  88  PHE PHE A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  PRO 90  90  90  PRO PRO A . n 
A 1 91  MET 91  91  91  MET MET A . n 
A 1 92  MET 92  92  92  MET MET A . n 
A 1 93  ASN 93  93  93  ASN ASN A . n 
A 1 94  VAL 94  94  94  VAL VAL A . n 
A 1 95  TYR 95  95  95  TYR TYR A . n 
A 1 96  LYS 96  96  96  LYS LYS A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  PHE 98  98  98  PHE PHE A . n 
A 1 99  LEU 99  99  99  LEU LEU A . n 
A 1 100 GLY 100 100 100 GLY GLY A . n 
A 1 101 ASN 101 101 101 ASN ASN A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 THR 104 104 104 THR THR A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PHE 108 108 108 PHE PHE A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 VAL 110 110 110 VAL VAL A . n 
A 1 111 GLU 111 111 111 GLU GLU A . n 
A 1 112 LEU 112 112 112 LEU LEU A . n 
A 1 113 GLU 113 113 113 GLU GLU A . n 
A 1 114 LYS 114 114 114 LYS LYS A . n 
A 1 115 SER 115 115 115 SER SER A . n 
A 1 116 SER 116 116 116 SER SER A . n 
A 1 117 LYS 117 117 117 LYS LYS A . n 
A 1 118 PHE 118 118 118 PHE PHE A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 ASP 120 120 120 ASP ASP A . n 
A 1 121 ILE 121 121 121 ILE ILE A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 ASP 123 123 123 ASP ASP A . n 
A 1 124 LEU 124 124 124 LEU LEU A . n 
A 1 125 LEU 125 125 125 LEU LEU A . n 
A 1 126 ARG 126 126 126 ARG ARG A . n 
A 1 127 SER 127 127 127 SER SER A . n 
A 1 128 HIS 128 128 128 HIS HIS A . n 
A 1 129 LEU 129 129 129 LEU LEU A . n 
A 1 130 PRO 130 130 130 PRO PRO A . n 
A 1 131 GLY 131 131 131 GLY GLY A . n 
A 1 132 ASP 132 132 132 ASP ASP A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 GLN 134 134 134 GLN GLN A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 ASP 136 136 136 ASP ASP A . n 
A 1 137 LEU 137 137 137 LEU LEU A . n 
A 1 138 ARG 138 138 138 ARG ARG A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 TYR 140 140 140 TYR TYR A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 MET 143 143 143 MET MET A . n 
A 1 144 PRO 144 144 144 PRO PRO A . n 
A 1 145 VAL 145 145 145 VAL VAL A . n 
A 1 146 GLN 146 146 146 GLN GLN A . n 
A 1 147 ARG 147 147 147 ARG ARG A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 PRO 149 149 149 PRO PRO A . n 
A 1 150 ARG 150 150 150 ARG ARG A . n 
A 1 151 TYR 151 151 151 TYR TYR A . n 
A 1 152 LYS 152 152 152 LYS LYS A . n 
A 1 153 LEU 153 153 153 LEU LEU A . n 
A 1 154 LEU 154 154 154 LEU LEU A . n 
A 1 155 LEU 155 155 155 LEU LEU A . n 
A 1 156 THR 156 156 156 THR THR A . n 
A 1 157 ASP 157 157 157 ASP ASP A . n 
A 1 158 LEU 158 158 158 LEU LEU A . n 
A 1 159 ILE 159 159 159 ILE ILE A . n 
A 1 160 LYS 160 160 160 LYS LYS A . n 
A 1 161 HIS 161 161 161 HIS HIS A . n 
A 1 162 THR 162 162 162 THR THR A . n 
A 1 163 ASP 163 163 163 ASP ASP A . n 
A 1 164 ASP 164 164 164 ASP ASP A . n 
A 1 165 ASP 165 165 165 ASP ASP A . n 
A 1 166 PHE 166 166 166 PHE PHE A . n 
A 1 167 VAL 167 167 167 VAL VAL A . n 
A 1 168 ASP 168 168 168 ASP ASP A . n 
A 1 169 LYS 169 169 169 LYS LYS A . n 
A 1 170 PRO 170 170 170 PRO PRO A . n 
A 1 171 LYS 171 171 171 LYS LYS A . n 
A 1 172 LEU 172 172 172 LEU LEU A . n 
A 1 173 ILE 173 173 173 ILE ILE A . n 
A 1 174 ASP 174 174 174 ASP ASP A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 ASP 177 177 177 ASP ASP A . n 
A 1 178 LYS 178 178 178 LYS LYS A . n 
A 1 179 ILE 179 179 179 ILE ILE A . n 
A 1 180 SER 180 180 180 SER SER A . n 
A 1 181 LYS 181 181 181 LYS LYS A . n 
A 1 182 LEU 182 182 182 LEU LEU A . n 
A 1 183 ALA 183 183 183 ALA ALA A . n 
A 1 184 THR 184 184 184 THR THR A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASN 187 187 187 ASN ASN A . n 
A 1 188 GLU 188 188 188 GLU GLU A . n 
A 1 189 VAL 189 189 189 VAL VAL A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 LYS 191 191 191 LYS LYS A . n 
A 1 192 GLU 192 192 192 GLU GLU A . n 
A 1 193 ARG 193 193 193 ARG ARG A . n 
A 1 194 SER 194 194 ?   ?   ?   A . n 
A 1 195 ARG 195 195 ?   ?   ?   A . n 
A 1 196 ASN 196 196 ?   ?   ?   A . n 
A 1 197 GLN 197 197 ?   ?   ?   A . n 
A 1 198 LYS 198 198 ?   ?   ?   A . n 
A 1 199 LEU 199 199 ?   ?   ?   A . n 
A 1 200 LEU 200 200 ?   ?   ?   A . n 
A 1 201 GLU 201 201 ?   ?   ?   A . n 
A 1 202 LEU 202 202 ?   ?   ?   A . n 
A 1 203 VAL 203 203 ?   ?   ?   A . n 
A 1 204 ASP 204 204 ?   ?   ?   A . n 
A 1 205 LYS 205 205 ?   ?   ?   A . n 
A 1 206 ILE 206 206 ?   ?   ?   A . n 
A 1 207 GLU 207 207 ?   ?   ?   A . n 
A 1 208 GLY 208 208 ?   ?   ?   A . n 
A 1 209 LEU 209 209 ?   ?   ?   A . n 
B 1 1   LYS 1   1   1   LYS LYS B . n 
B 1 2   GLU 2   2   2   GLU GLU B . n 
B 1 3   ASP 3   3   3   ASP ASP B . n 
B 1 4   TYR 4   4   4   TYR TYR B . n 
B 1 5   ARG 5   5   5   ARG ARG B . n 
B 1 6   GLU 6   6   6   GLU GLU B . n 
B 1 7   ARG 7   7   7   ARG ARG B . n 
B 1 8   ILE 8   8   8   ILE ILE B . n 
B 1 9   VAL 9   9   9   VAL VAL B . n 
B 1 10  ASN 10  10  10  ASN ASN B . n 
B 1 11  GLU 11  11  11  GLU GLU B . n 
B 1 12  MET 12  12  12  MET MET B . n 
B 1 13  PHE 13  13  13  PHE PHE B . n 
B 1 14  ASP 14  14  14  ASP ASP B . n 
B 1 15  THR 15  15  15  THR THR B . n 
B 1 16  GLU 16  16  16  GLU GLU B . n 
B 1 17  LYS 17  17  17  LYS LYS B . n 
B 1 18  SER 18  18  18  SER SER B . n 
B 1 19  TYR 19  19  19  TYR TYR B . n 
B 1 20  VAL 20  20  20  VAL VAL B . n 
B 1 21  ASN 21  21  21  ASN ASN B . n 
B 1 22  SER 22  22  22  SER SER B . n 
B 1 23  MET 23  23  23  MET MET B . n 
B 1 24  GLU 24  24  24  GLU GLU B . n 
B 1 25  ILE 25  25  25  ILE ILE B . n 
B 1 26  CYS 26  26  26  CYS CYS B . n 
B 1 27  ILE 27  27  27  ILE ILE B . n 
B 1 28  LYS 28  28  28  LYS LYS B . n 
B 1 29  GLY 29  29  29  GLY GLY B . n 
B 1 30  TYR 30  30  30  TYR TYR B . n 
B 1 31  TYR 31  31  31  TYR TYR B . n 
B 1 32  GLU 32  32  32  GLU GLU B . n 
B 1 33  PRO 33  33  33  PRO PRO B . n 
B 1 34  LEU 34  34  34  LEU LEU B . n 
B 1 35  ILE 35  35  35  ILE ILE B . n 
B 1 36  GLN 36  36  36  GLN GLN B . n 
B 1 37  SER 37  37  37  SER SER B . n 
B 1 38  GLY 38  38  38  GLY GLY B . n 
B 1 39  HIS 39  39  39  HIS HIS B . n 
B 1 40  SER 40  40  40  SER SER B . n 
B 1 41  VAL 41  41  41  VAL VAL B . n 
B 1 42  ALA 42  42  42  ALA ALA B . n 
B 1 43  PRO 43  43  43  PRO PRO B . n 
B 1 44  ALA 44  44  44  ALA ALA B . n 
B 1 45  ASP 45  45  45  ASP ASP B . n 
B 1 46  LYS 46  46  46  LYS LYS B . n 
B 1 47  VAL 47  47  47  VAL VAL B . n 
B 1 48  ASN 48  48  48  ASN ASN B . n 
B 1 49  ALA 49  49  49  ALA ALA B . n 
B 1 50  VAL 50  50  50  VAL VAL B . n 
B 1 51  PHE 51  51  51  PHE PHE B . n 
B 1 52  LEU 52  52  52  LEU LEU B . n 
B 1 53  HIS 53  53  53  HIS HIS B . n 
B 1 54  PHE 54  54  54  PHE PHE B . n 
B 1 55  GLN 55  55  55  GLN GLN B . n 
B 1 56  SER 56  56  56  SER SER B . n 
B 1 57  VAL 57  57  57  VAL VAL B . n 
B 1 58  LEU 58  58  58  LEU LEU B . n 
B 1 59  SER 59  59  59  SER SER B . n 
B 1 60  ILE 60  60  60  ILE ILE B . n 
B 1 61  ASN 61  61  61  ASN ASN B . n 
B 1 62  LYS 62  62  62  LYS LYS B . n 
B 1 63  GLU 63  63  63  GLU GLU B . n 
B 1 64  LEU 64  64  64  LEU LEU B . n 
B 1 65  LEU 65  65  65  LEU LEU B . n 
B 1 66  LYS 66  66  66  LYS LYS B . n 
B 1 67  ASN 67  67  67  ASN ASN B . n 
B 1 68  MET 68  68  68  MET MET B . n 
B 1 69  THR 69  69  69  THR THR B . n 
B 1 70  GLU 70  70  70  GLU GLU B . n 
B 1 71  LEU 71  71  71  LEU LEU B . n 
B 1 72  LYS 72  72  72  LYS LYS B . n 
B 1 73  GLU 73  73  73  GLU GLU B . n 
B 1 74  LYS 74  74  74  LYS LYS B . n 
B 1 75  GLY 75  75  75  GLY GLY B . n 
B 1 76  GLU 76  76  76  GLU GLU B . n 
B 1 77  LEU 77  77  77  LEU LEU B . n 
B 1 78  SER 78  78  78  SER SER B . n 
B 1 79  THR 79  79  79  THR THR B . n 
B 1 80  ARG 80  80  80  ARG ARG B . n 
B 1 81  LEU 81  81  81  LEU LEU B . n 
B 1 82  GLY 82  82  82  GLY GLY B . n 
B 1 83  GLU 83  83  83  GLU GLU B . n 
B 1 84  ALA 84  84  84  ALA ALA B . n 
B 1 85  PHE 85  85  85  PHE PHE B . n 
B 1 86  SER 86  86  86  SER SER B . n 
B 1 87  GLN 87  87  87  GLN GLN B . n 
B 1 88  PHE 88  88  88  PHE PHE B . n 
B 1 89  ILE 89  89  89  ILE ILE B . n 
B 1 90  PRO 90  90  90  PRO PRO B . n 
B 1 91  MET 91  91  91  MET MET B . n 
B 1 92  MET 92  92  92  MET MET B . n 
B 1 93  ASN 93  93  93  ASN ASN B . n 
B 1 94  VAL 94  94  94  VAL VAL B . n 
B 1 95  TYR 95  95  95  TYR TYR B . n 
B 1 96  LYS 96  96  96  LYS LYS B . n 
B 1 97  LEU 97  97  97  LEU LEU B . n 
B 1 98  PHE 98  98  98  PHE PHE B . n 
B 1 99  LEU 99  99  99  LEU LEU B . n 
B 1 100 GLY 100 100 100 GLY GLY B . n 
B 1 101 ASN 101 101 101 ASN ASN B . n 
B 1 102 SER 102 102 102 SER SER B . n 
B 1 103 ASP 103 103 103 ASP ASP B . n 
B 1 104 THR 104 104 104 THR THR B . n 
B 1 105 SER 105 105 105 SER SER B . n 
B 1 106 LEU 106 106 106 LEU LEU B . n 
B 1 107 GLN 107 107 107 GLN GLN B . n 
B 1 108 PHE 108 108 108 PHE PHE B . n 
B 1 109 LEU 109 109 109 LEU LEU B . n 
B 1 110 VAL 110 110 110 VAL VAL B . n 
B 1 111 GLU 111 111 111 GLU GLU B . n 
B 1 112 LEU 112 112 112 LEU LEU B . n 
B 1 113 GLU 113 113 113 GLU GLU B . n 
B 1 114 LYS 114 114 114 LYS LYS B . n 
B 1 115 SER 115 115 115 SER SER B . n 
B 1 116 SER 116 116 116 SER SER B . n 
B 1 117 LYS 117 117 117 LYS LYS B . n 
B 1 118 PHE 118 118 118 PHE PHE B . n 
B 1 119 ASN 119 119 119 ASN ASN B . n 
B 1 120 ASP 120 120 120 ASP ASP B . n 
B 1 121 ILE 121 121 121 ILE ILE B . n 
B 1 122 LEU 122 122 122 LEU LEU B . n 
B 1 123 ASP 123 123 123 ASP ASP B . n 
B 1 124 LEU 124 124 124 LEU LEU B . n 
B 1 125 LEU 125 125 125 LEU LEU B . n 
B 1 126 ARG 126 126 126 ARG ARG B . n 
B 1 127 SER 127 127 127 SER SER B . n 
B 1 128 HIS 128 128 128 HIS HIS B . n 
B 1 129 LEU 129 129 129 LEU LEU B . n 
B 1 130 PRO 130 130 130 PRO PRO B . n 
B 1 131 GLY 131 131 131 GLY GLY B . n 
B 1 132 ASP 132 132 132 ASP ASP B . n 
B 1 133 ASN 133 133 133 ASN ASN B . n 
B 1 134 GLN 134 134 134 GLN GLN B . n 
B 1 135 LEU 135 135 135 LEU LEU B . n 
B 1 136 ASP 136 136 136 ASP ASP B . n 
B 1 137 LEU 137 137 137 LEU LEU B . n 
B 1 138 ARG 138 138 138 ARG ARG B . n 
B 1 139 SER 139 139 139 SER SER B . n 
B 1 140 TYR 140 140 140 TYR TYR B . n 
B 1 141 LEU 141 141 141 LEU LEU B . n 
B 1 142 ILE 142 142 142 ILE ILE B . n 
B 1 143 MET 143 143 143 MET MET B . n 
B 1 144 PRO 144 144 144 PRO PRO B . n 
B 1 145 VAL 145 145 145 VAL VAL B . n 
B 1 146 GLN 146 146 146 GLN GLN B . n 
B 1 147 ARG 147 147 147 ARG ARG B . n 
B 1 148 LEU 148 148 148 LEU LEU B . n 
B 1 149 PRO 149 149 149 PRO PRO B . n 
B 1 150 ARG 150 150 150 ARG ARG B . n 
B 1 151 TYR 151 151 151 TYR TYR B . n 
B 1 152 LYS 152 152 152 LYS LYS B . n 
B 1 153 LEU 153 153 153 LEU LEU B . n 
B 1 154 LEU 154 154 154 LEU LEU B . n 
B 1 155 LEU 155 155 155 LEU LEU B . n 
B 1 156 THR 156 156 156 THR THR B . n 
B 1 157 ASP 157 157 157 ASP ASP B . n 
B 1 158 LEU 158 158 158 LEU LEU B . n 
B 1 159 ILE 159 159 159 ILE ILE B . n 
B 1 160 LYS 160 160 160 LYS LYS B . n 
B 1 161 HIS 161 161 161 HIS HIS B . n 
B 1 162 THR 162 162 162 THR THR B . n 
B 1 163 ASP 163 163 163 ASP ASP B . n 
B 1 164 ASP 164 164 164 ASP ASP B . n 
B 1 165 ASP 165 165 165 ASP ASP B . n 
B 1 166 PHE 166 166 166 PHE PHE B . n 
B 1 167 VAL 167 167 167 VAL VAL B . n 
B 1 168 ASP 168 168 168 ASP ASP B . n 
B 1 169 LYS 169 169 169 LYS LYS B . n 
B 1 170 PRO 170 170 170 PRO PRO B . n 
B 1 171 LYS 171 171 171 LYS LYS B . n 
B 1 172 LEU 172 172 172 LEU LEU B . n 
B 1 173 ILE 173 173 173 ILE ILE B . n 
B 1 174 ASP 174 174 174 ASP ASP B . n 
B 1 175 ALA 175 175 175 ALA ALA B . n 
B 1 176 LEU 176 176 176 LEU LEU B . n 
B 1 177 ASP 177 177 177 ASP ASP B . n 
B 1 178 LYS 178 178 178 LYS LYS B . n 
B 1 179 ILE 179 179 179 ILE ILE B . n 
B 1 180 SER 180 180 180 SER SER B . n 
B 1 181 LYS 181 181 181 LYS LYS B . n 
B 1 182 LEU 182 182 182 LEU LEU B . n 
B 1 183 ALA 183 183 183 ALA ALA B . n 
B 1 184 THR 184 184 184 THR THR B . n 
B 1 185 LEU 185 185 185 LEU LEU B . n 
B 1 186 VAL 186 186 186 VAL VAL B . n 
B 1 187 ASN 187 187 187 ASN ASN B . n 
B 1 188 GLU 188 188 188 GLU GLU B . n 
B 1 189 VAL 189 189 189 VAL VAL B . n 
B 1 190 ILE 190 190 190 ILE ILE B . n 
B 1 191 LYS 191 191 191 LYS LYS B . n 
B 1 192 GLU 192 192 192 GLU GLU B . n 
B 1 193 ARG 193 193 193 ARG ARG B . n 
B 1 194 SER 194 194 194 SER SER B . n 
B 1 195 ARG 195 195 195 ARG ARG B . n 
B 1 196 ASN 196 196 196 ASN ASN B . n 
B 1 197 GLN 197 197 197 GLN GLN B . n 
B 1 198 LYS 198 198 198 LYS LYS B . n 
B 1 199 LEU 199 199 199 LEU LEU B . n 
B 1 200 LEU 200 200 200 LEU LEU B . n 
B 1 201 GLU 201 201 201 GLU GLU B . n 
B 1 202 LEU 202 202 202 LEU LEU B . n 
B 1 203 VAL 203 203 203 VAL VAL B . n 
B 1 204 ASP 204 204 ?   ?   ?   B . n 
B 1 205 LYS 205 205 ?   ?   ?   B . n 
B 1 206 ILE 206 206 ?   ?   ?   B . n 
B 1 207 GLU 207 207 ?   ?   ?   B . n 
B 1 208 GLY 208 208 ?   ?   ?   B . n 
B 1 209 LEU 209 209 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        CIT 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   CIT 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 CIT 1  301 202 CIT CIT B . 
D 3 HOH 1  301 145 HOH HOH A . 
D 3 HOH 2  302 189 HOH HOH A . 
D 3 HOH 3  303 35  HOH HOH A . 
D 3 HOH 4  304 181 HOH HOH A . 
D 3 HOH 5  305 162 HOH HOH A . 
D 3 HOH 6  306 13  HOH HOH A . 
D 3 HOH 7  307 149 HOH HOH A . 
D 3 HOH 8  308 67  HOH HOH A . 
D 3 HOH 9  309 114 HOH HOH A . 
D 3 HOH 10 310 122 HOH HOH A . 
D 3 HOH 11 311 142 HOH HOH A . 
D 3 HOH 12 312 59  HOH HOH A . 
D 3 HOH 13 313 45  HOH HOH A . 
D 3 HOH 14 314 43  HOH HOH A . 
D 3 HOH 15 315 12  HOH HOH A . 
D 3 HOH 16 316 36  HOH HOH A . 
D 3 HOH 17 317 46  HOH HOH A . 
D 3 HOH 18 318 68  HOH HOH A . 
D 3 HOH 19 319 192 HOH HOH A . 
D 3 HOH 20 320 66  HOH HOH A . 
D 3 HOH 21 321 7   HOH HOH A . 
D 3 HOH 22 322 14  HOH HOH A . 
D 3 HOH 23 323 180 HOH HOH A . 
D 3 HOH 24 324 188 HOH HOH A . 
D 3 HOH 25 325 26  HOH HOH A . 
D 3 HOH 26 326 195 HOH HOH A . 
D 3 HOH 27 327 74  HOH HOH A . 
D 3 HOH 28 328 37  HOH HOH A . 
D 3 HOH 29 329 143 HOH HOH A . 
D 3 HOH 30 330 103 HOH HOH A . 
D 3 HOH 31 331 21  HOH HOH A . 
D 3 HOH 32 332 113 HOH HOH A . 
D 3 HOH 33 333 15  HOH HOH A . 
D 3 HOH 34 334 194 HOH HOH A . 
D 3 HOH 35 335 25  HOH HOH A . 
D 3 HOH 36 336 101 HOH HOH A . 
D 3 HOH 37 337 133 HOH HOH A . 
D 3 HOH 38 338 190 HOH HOH A . 
D 3 HOH 39 339 187 HOH HOH A . 
D 3 HOH 40 340 196 HOH HOH A . 
D 3 HOH 41 341 97  HOH HOH A . 
D 3 HOH 42 342 44  HOH HOH A . 
D 3 HOH 43 343 109 HOH HOH A . 
E 3 HOH 1  401 151 HOH HOH B . 
E 3 HOH 2  402 141 HOH HOH B . 
E 3 HOH 3  403 79  HOH HOH B . 
E 3 HOH 4  404 57  HOH HOH B . 
E 3 HOH 5  405 1   HOH HOH B . 
E 3 HOH 6  406 20  HOH HOH B . 
E 3 HOH 7  407 139 HOH HOH B . 
E 3 HOH 8  408 120 HOH HOH B . 
E 3 HOH 9  409 54  HOH HOH B . 
E 3 HOH 10 410 138 HOH HOH B . 
E 3 HOH 11 411 80  HOH HOH B . 
E 3 HOH 12 412 98  HOH HOH B . 
E 3 HOH 13 413 110 HOH HOH B . 
E 3 HOH 14 414 40  HOH HOH B . 
E 3 HOH 15 415 19  HOH HOH B . 
E 3 HOH 16 416 32  HOH HOH B . 
E 3 HOH 17 417 50  HOH HOH B . 
E 3 HOH 18 418 62  HOH HOH B . 
E 3 HOH 19 419 4   HOH HOH B . 
E 3 HOH 20 420 71  HOH HOH B . 
E 3 HOH 21 421 102 HOH HOH B . 
E 3 HOH 22 422 49  HOH HOH B . 
E 3 HOH 23 423 10  HOH HOH B . 
E 3 HOH 24 424 137 HOH HOH B . 
E 3 HOH 25 425 47  HOH HOH B . 
E 3 HOH 26 426 81  HOH HOH B . 
E 3 HOH 27 427 96  HOH HOH B . 
E 3 HOH 28 428 117 HOH HOH B . 
E 3 HOH 29 429 108 HOH HOH B . 
E 3 HOH 30 430 136 HOH HOH B . 
E 3 HOH 31 431 163 HOH HOH B . 
E 3 HOH 32 432 6   HOH HOH B . 
E 3 HOH 33 433 58  HOH HOH B . 
E 3 HOH 34 434 63  HOH HOH B . 
E 3 HOH 35 435 193 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A LYS 1   ? CD  ? A LYS 1   CD  
2   1 Y 1 A LYS 1   ? CE  ? A LYS 1   CE  
3   1 Y 1 A LYS 1   ? NZ  ? A LYS 1   NZ  
4   1 Y 1 A GLU 2   ? CG  ? A GLU 2   CG  
5   1 Y 1 A GLU 2   ? CD  ? A GLU 2   CD  
6   1 Y 1 A GLU 2   ? OE1 ? A GLU 2   OE1 
7   1 Y 1 A GLU 2   ? OE2 ? A GLU 2   OE2 
8   1 Y 1 A LYS 17  ? CG  ? A LYS 17  CG  
9   1 Y 1 A LYS 17  ? CD  ? A LYS 17  CD  
10  1 Y 1 A LYS 17  ? CE  ? A LYS 17  CE  
11  1 Y 1 A LYS 17  ? NZ  ? A LYS 17  NZ  
12  1 Y 1 A LYS 28  ? CG  ? A LYS 28  CG  
13  1 Y 1 A LYS 28  ? CD  ? A LYS 28  CD  
14  1 Y 1 A LYS 28  ? CE  ? A LYS 28  CE  
15  1 Y 1 A LYS 28  ? NZ  ? A LYS 28  NZ  
16  1 Y 1 A GLN 36  ? CG  ? A GLN 36  CG  
17  1 Y 1 A GLN 36  ? CD  ? A GLN 36  CD  
18  1 Y 1 A GLN 36  ? OE1 ? A GLN 36  OE1 
19  1 Y 1 A GLN 36  ? NE2 ? A GLN 36  NE2 
20  1 Y 1 A SER 37  ? OG  ? A SER 37  OG  
21  1 Y 1 A GLU 63  ? CG  ? A GLU 63  CG  
22  1 Y 1 A GLU 63  ? CD  ? A GLU 63  CD  
23  1 Y 1 A GLU 63  ? OE1 ? A GLU 63  OE1 
24  1 Y 1 A GLU 63  ? OE2 ? A GLU 63  OE2 
25  1 Y 1 A GLU 73  ? CG  ? A GLU 73  CG  
26  1 Y 1 A GLU 73  ? CD  ? A GLU 73  CD  
27  1 Y 1 A GLU 73  ? OE1 ? A GLU 73  OE1 
28  1 Y 1 A GLU 73  ? OE2 ? A GLU 73  OE2 
29  1 Y 1 A LYS 74  ? CG  ? A LYS 74  CG  
30  1 Y 1 A LYS 74  ? CD  ? A LYS 74  CD  
31  1 Y 1 A LYS 74  ? CE  ? A LYS 74  CE  
32  1 Y 1 A LYS 74  ? NZ  ? A LYS 74  NZ  
33  1 Y 1 A GLU 76  ? CG  ? A GLU 76  CG  
34  1 Y 1 A GLU 76  ? CD  ? A GLU 76  CD  
35  1 Y 1 A GLU 76  ? OE1 ? A GLU 76  OE1 
36  1 Y 1 A GLU 76  ? OE2 ? A GLU 76  OE2 
37  1 Y 1 A LYS 96  ? CD  ? A LYS 96  CD  
38  1 Y 1 A LYS 96  ? CE  ? A LYS 96  CE  
39  1 Y 1 A LYS 96  ? NZ  ? A LYS 96  NZ  
40  1 Y 1 A LEU 106 ? CG  ? A LEU 106 CG  
41  1 Y 1 A LEU 106 ? CD1 ? A LEU 106 CD1 
42  1 Y 1 A LEU 106 ? CD2 ? A LEU 106 CD2 
43  1 Y 1 A ASP 123 ? CG  ? A ASP 123 CG  
44  1 Y 1 A ASP 123 ? OD1 ? A ASP 123 OD1 
45  1 Y 1 A ASP 123 ? OD2 ? A ASP 123 OD2 
46  1 Y 1 A LEU 124 ? CG  ? A LEU 124 CG  
47  1 Y 1 A LEU 124 ? CD1 ? A LEU 124 CD1 
48  1 Y 1 A LEU 124 ? CD2 ? A LEU 124 CD2 
49  1 Y 1 A ASP 132 ? CG  ? A ASP 132 CG  
50  1 Y 1 A ASP 132 ? OD1 ? A ASP 132 OD1 
51  1 Y 1 A ASP 132 ? OD2 ? A ASP 132 OD2 
52  1 Y 1 A ASN 133 ? CG  ? A ASN 133 CG  
53  1 Y 1 A ASN 133 ? OD1 ? A ASN 133 OD1 
54  1 Y 1 A ASN 133 ? ND2 ? A ASN 133 ND2 
55  1 Y 1 A LYS 152 ? CE  ? A LYS 152 CE  
56  1 Y 1 A LYS 152 ? NZ  ? A LYS 152 NZ  
57  1 Y 1 A LYS 160 ? CG  ? A LYS 160 CG  
58  1 Y 1 A LYS 160 ? CD  ? A LYS 160 CD  
59  1 Y 1 A LYS 160 ? CE  ? A LYS 160 CE  
60  1 Y 1 A LYS 160 ? NZ  ? A LYS 160 NZ  
61  1 Y 1 A VAL 167 ? CG1 ? A VAL 167 CG1 
62  1 Y 1 A VAL 167 ? CG2 ? A VAL 167 CG2 
63  1 Y 1 A LYS 181 ? CD  ? A LYS 181 CD  
64  1 Y 1 A LYS 181 ? CE  ? A LYS 181 CE  
65  1 Y 1 A LYS 181 ? NZ  ? A LYS 181 NZ  
66  1 Y 1 A LEU 182 ? CG  ? A LEU 182 CG  
67  1 Y 1 A LEU 182 ? CD1 ? A LEU 182 CD1 
68  1 Y 1 A LEU 182 ? CD2 ? A LEU 182 CD2 
69  1 Y 1 A GLU 188 ? CG  ? A GLU 188 CG  
70  1 Y 1 A GLU 188 ? CD  ? A GLU 188 CD  
71  1 Y 1 A GLU 188 ? OE1 ? A GLU 188 OE1 
72  1 Y 1 A GLU 188 ? OE2 ? A GLU 188 OE2 
73  1 Y 1 B GLU 2   ? CG  ? B GLU 2   CG  
74  1 Y 1 B GLU 2   ? CD  ? B GLU 2   CD  
75  1 Y 1 B GLU 2   ? OE1 ? B GLU 2   OE1 
76  1 Y 1 B GLU 2   ? OE2 ? B GLU 2   OE2 
77  1 Y 1 B ASP 3   ? CG  ? B ASP 3   CG  
78  1 Y 1 B ASP 3   ? OD1 ? B ASP 3   OD1 
79  1 Y 1 B ASP 3   ? OD2 ? B ASP 3   OD2 
80  1 Y 1 B GLU 11  ? CG  ? B GLU 11  CG  
81  1 Y 1 B GLU 11  ? CD  ? B GLU 11  CD  
82  1 Y 1 B GLU 11  ? OE1 ? B GLU 11  OE1 
83  1 Y 1 B GLU 11  ? OE2 ? B GLU 11  OE2 
84  1 Y 1 B MET 12  ? CG  ? B MET 12  CG  
85  1 Y 1 B MET 12  ? SD  ? B MET 12  SD  
86  1 Y 1 B MET 12  ? CE  ? B MET 12  CE  
87  1 Y 1 B LYS 17  ? CG  ? B LYS 17  CG  
88  1 Y 1 B LYS 17  ? CD  ? B LYS 17  CD  
89  1 Y 1 B LYS 17  ? CE  ? B LYS 17  CE  
90  1 Y 1 B LYS 17  ? NZ  ? B LYS 17  NZ  
91  1 Y 1 B LYS 28  ? CG  ? B LYS 28  CG  
92  1 Y 1 B LYS 28  ? CD  ? B LYS 28  CD  
93  1 Y 1 B LYS 28  ? CE  ? B LYS 28  CE  
94  1 Y 1 B LYS 28  ? NZ  ? B LYS 28  NZ  
95  1 Y 1 B GLN 36  ? CG  ? B GLN 36  CG  
96  1 Y 1 B GLN 36  ? CD  ? B GLN 36  CD  
97  1 Y 1 B GLN 36  ? OE1 ? B GLN 36  OE1 
98  1 Y 1 B GLN 36  ? NE2 ? B GLN 36  NE2 
99  1 Y 1 B HIS 39  ? CG  ? B HIS 39  CG  
100 1 Y 1 B HIS 39  ? ND1 ? B HIS 39  ND1 
101 1 Y 1 B HIS 39  ? CD2 ? B HIS 39  CD2 
102 1 Y 1 B HIS 39  ? CE1 ? B HIS 39  CE1 
103 1 Y 1 B HIS 39  ? NE2 ? B HIS 39  NE2 
104 1 Y 1 B SER 40  ? OG  ? B SER 40  OG  
105 1 Y 1 B LYS 46  ? CD  ? B LYS 46  CD  
106 1 Y 1 B LYS 46  ? CE  ? B LYS 46  CE  
107 1 Y 1 B LYS 46  ? NZ  ? B LYS 46  NZ  
108 1 Y 1 B GLU 63  ? CG  ? B GLU 63  CG  
109 1 Y 1 B GLU 63  ? CD  ? B GLU 63  CD  
110 1 Y 1 B GLU 63  ? OE1 ? B GLU 63  OE1 
111 1 Y 1 B GLU 63  ? OE2 ? B GLU 63  OE2 
112 1 Y 1 B GLU 73  ? CG  ? B GLU 73  CG  
113 1 Y 1 B GLU 73  ? CD  ? B GLU 73  CD  
114 1 Y 1 B GLU 73  ? OE1 ? B GLU 73  OE1 
115 1 Y 1 B GLU 73  ? OE2 ? B GLU 73  OE2 
116 1 Y 1 B LYS 74  ? CG  ? B LYS 74  CG  
117 1 Y 1 B LYS 74  ? CD  ? B LYS 74  CD  
118 1 Y 1 B LYS 74  ? CE  ? B LYS 74  CE  
119 1 Y 1 B LYS 74  ? NZ  ? B LYS 74  NZ  
120 1 Y 1 B LYS 96  ? CE  ? B LYS 96  CE  
121 1 Y 1 B LYS 96  ? NZ  ? B LYS 96  NZ  
122 1 Y 1 B SER 116 ? OG  ? B SER 116 OG  
123 1 Y 1 B ASP 123 ? CG  ? B ASP 123 CG  
124 1 Y 1 B ASP 123 ? OD1 ? B ASP 123 OD1 
125 1 Y 1 B ASP 123 ? OD2 ? B ASP 123 OD2 
126 1 Y 1 B ASP 132 ? CG  ? B ASP 132 CG  
127 1 Y 1 B ASP 132 ? OD1 ? B ASP 132 OD1 
128 1 Y 1 B ASP 132 ? OD2 ? B ASP 132 OD2 
129 1 Y 1 B ASN 133 ? CG  ? B ASN 133 CG  
130 1 Y 1 B ASN 133 ? OD1 ? B ASN 133 OD1 
131 1 Y 1 B ASN 133 ? ND2 ? B ASN 133 ND2 
132 1 Y 1 B LYS 152 ? NZ  ? B LYS 152 NZ  
133 1 Y 1 B LYS 160 ? CG  ? B LYS 160 CG  
134 1 Y 1 B LYS 160 ? CD  ? B LYS 160 CD  
135 1 Y 1 B LYS 160 ? CE  ? B LYS 160 CE  
136 1 Y 1 B LYS 160 ? NZ  ? B LYS 160 NZ  
137 1 Y 1 B ASP 163 ? CG  ? B ASP 163 CG  
138 1 Y 1 B ASP 163 ? OD1 ? B ASP 163 OD1 
139 1 Y 1 B ASP 163 ? OD2 ? B ASP 163 OD2 
140 1 Y 1 B VAL 167 ? CG1 ? B VAL 167 CG1 
141 1 Y 1 B VAL 167 ? CG2 ? B VAL 167 CG2 
142 1 Y 1 B LYS 181 ? CG  ? B LYS 181 CG  
143 1 Y 1 B LYS 181 ? CD  ? B LYS 181 CD  
144 1 Y 1 B LYS 181 ? CE  ? B LYS 181 CE  
145 1 Y 1 B LYS 181 ? NZ  ? B LYS 181 NZ  
146 1 Y 1 B LEU 185 ? CG  ? B LEU 185 CG  
147 1 Y 1 B LEU 185 ? CD1 ? B LEU 185 CD1 
148 1 Y 1 B LEU 185 ? CD2 ? B LEU 185 CD2 
149 1 Y 1 B ASN 187 ? CG  ? B ASN 187 CG  
150 1 Y 1 B ASN 187 ? OD1 ? B ASN 187 OD1 
151 1 Y 1 B ASN 187 ? ND2 ? B ASN 187 ND2 
152 1 Y 1 B GLU 188 ? CG  ? B GLU 188 CG  
153 1 Y 1 B GLU 188 ? CD  ? B GLU 188 CD  
154 1 Y 1 B GLU 188 ? OE1 ? B GLU 188 OE1 
155 1 Y 1 B GLU 188 ? OE2 ? B GLU 188 OE2 
156 1 Y 1 B ILE 190 ? CG1 ? B ILE 190 CG1 
157 1 Y 1 B ILE 190 ? CG2 ? B ILE 190 CG2 
158 1 Y 1 B ILE 190 ? CD1 ? B ILE 190 CD1 
159 1 Y 1 B LYS 191 ? CG  ? B LYS 191 CG  
160 1 Y 1 B LYS 191 ? CD  ? B LYS 191 CD  
161 1 Y 1 B LYS 191 ? CE  ? B LYS 191 CE  
162 1 Y 1 B LYS 191 ? NZ  ? B LYS 191 NZ  
163 1 Y 1 B GLU 192 ? CG  ? B GLU 192 CG  
164 1 Y 1 B GLU 192 ? CD  ? B GLU 192 CD  
165 1 Y 1 B GLU 192 ? OE1 ? B GLU 192 OE1 
166 1 Y 1 B GLU 192 ? OE2 ? B GLU 192 OE2 
167 1 Y 1 B ARG 193 ? CD  ? B ARG 193 CD  
168 1 Y 1 B ARG 193 ? NE  ? B ARG 193 NE  
169 1 Y 1 B ARG 193 ? CZ  ? B ARG 193 CZ  
170 1 Y 1 B ARG 193 ? NH1 ? B ARG 193 NH1 
171 1 Y 1 B ARG 193 ? NH2 ? B ARG 193 NH2 
172 1 Y 1 B ARG 195 ? CG  ? B ARG 195 CG  
173 1 Y 1 B ARG 195 ? CD  ? B ARG 195 CD  
174 1 Y 1 B ARG 195 ? NE  ? B ARG 195 NE  
175 1 Y 1 B ARG 195 ? CZ  ? B ARG 195 CZ  
176 1 Y 1 B ARG 195 ? NH1 ? B ARG 195 NH1 
177 1 Y 1 B ARG 195 ? NH2 ? B ARG 195 NH2 
178 1 Y 1 B LEU 199 ? CG  ? B LEU 199 CG  
179 1 Y 1 B LEU 199 ? CD1 ? B LEU 199 CD1 
180 1 Y 1 B LEU 199 ? CD2 ? B LEU 199 CD2 
181 1 Y 1 B GLU 201 ? CG  ? B GLU 201 CG  
182 1 Y 1 B GLU 201 ? CD  ? B GLU 201 CD  
183 1 Y 1 B GLU 201 ? OE1 ? B GLU 201 OE1 
184 1 Y 1 B GLU 201 ? OE2 ? B GLU 201 OE2 
185 1 Y 1 B VAL 203 ? CG1 ? B VAL 203 CG1 
186 1 Y 1 B VAL 203 ? CG2 ? B VAL 203 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0403 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? BALBES   ? ? ? .        4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   118.275 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZLF 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     56.590 
_cell.length_a_esd                 ? 
_cell.length_b                     69.337 
_cell.length_b_esd                 ? 
_cell.length_c                     57.615 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZLF 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZLF 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.12 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.9 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.5M Sodium Citrate tribasic dihydrate, 0.1M Sodium Citrate pH 6.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-02-04 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97242 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID23-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97242 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID23-1 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8ZLF 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.48 
_reflns.d_resolution_low                               50.741 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     16337 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           90.40 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          2.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.480 
_reflns_shell.d_res_low                                     5.544 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1780 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.93 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -4.040 
_refine.aniso_B[1][2]                            0.000 
_refine.aniso_B[1][3]                            -1.922 
_refine.aniso_B[2][2]                            6.717 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            -0.386 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               39.861 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.943 
_refine.correlation_coeff_Fo_to_Fc_free          0.923 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZLF 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.480 
_refine.ls_d_res_low                             50.741 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     12690 
_refine.ls_number_reflns_R_free                  697 
_refine.ls_number_reflns_R_work                  11993 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    90.404 
_refine.ls_percent_reflns_R_free                 5.493 
_refine.ls_R_factor_all                          0.237 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2893 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2339 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  0.386 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             13.149 
_refine.overall_SU_ML                            0.283 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.480 
_refine_hist.d_res_low                        50.741 
_refine_hist.number_atoms_solvent             78 
_refine_hist.number_atoms_total               3128 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3037 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         13 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007  0.012  3100  ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  2937  ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.423  1.639  4203  ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.486  1.566  6727  ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.440  5.000  394   ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 11.925 5.000  15    ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 20.102 10.000 523   ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.331 10.000 126   ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.067  0.200  500   ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.006  0.020  3575  ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  673   ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.247  0.200  898   ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.207  0.200  2937  ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.191  0.200  1584  ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.078  0.200  1796  ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.190  0.200  102   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.020  0.200  1     ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.289  0.200  12    ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.324  0.200  52    ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.158  0.200  6     ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 4.465  4.232  1582  ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 4.465  4.232  1582  ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 6.743  7.605  1974  ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 6.743  7.604  1975  ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 5.263  4.580  1518  ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 5.253  4.583  1518  ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 8.162  8.237  2229  ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 8.164  8.236  2230  ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 11.517 50.732 13342 ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 11.516 50.669 13324 ? r_lrange_other                 ? ? 
'X-RAY DIFFRACTION' ? 0.126  0.050  5945  ? r_ncsr_local_group_1           ? ? 
# 
loop_
_refine_ls_restr_ncs.pdbx_refine_id 
_refine_ls_restr_ncs.dom_id 
_refine_ls_restr_ncs.ncs_model_details 
_refine_ls_restr_ncs.rms_dev_B_iso 
_refine_ls_restr_ncs.rms_dev_position 
_refine_ls_restr_ncs.weight_B_iso 
_refine_ls_restr_ncs.weight_position 
_refine_ls_restr_ncs.pdbx_ordinal 
_refine_ls_restr_ncs.pdbx_type 
_refine_ls_restr_ncs.pdbx_asym_id 
_refine_ls_restr_ncs.pdbx_auth_asym_id 
_refine_ls_restr_ncs.pdbx_number 
_refine_ls_restr_ncs.pdbx_rms 
_refine_ls_restr_ncs.pdbx_weight 
_refine_ls_restr_ncs.pdbx_ens_id 
'X-RAY DIFFRACTION' 1 ? ? 0.12605 ? 0.05008 1 'Local ncs' ? A ? ? ? 1 
'X-RAY DIFFRACTION' 2 ? ? 0.12605 ? 0.05008 2 'Local ncs' ? A ? ? ? 1 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.480  2.544  1027 . 49 974 99.6105  . 0.293 . . 0.290 . . . . . 0.280 . 20 . 0.945 0.916 0.360 
'X-RAY DIFFRACTION' 2.544  2.614  994  . 30 770 80.4829  . 0.349 . . 0.348 . . . . . 0.324 . 20 . 0.932 0.911 0.368 
'X-RAY DIFFRACTION' 2.614  2.689  979  . 0  2   0.2043   . 0.310 . . 0.310 . . . . . 0.302 . 20 . 0.944 .     .     
'X-RAY DIFFRACTION' 2.689  2.772  950  . 45 785 87.3684  . 0.355 . . 0.353 . . . . . 0.323 . 20 . 0.930 0.912 0.393 
'X-RAY DIFFRACTION' 2.772  2.863  912  . 48 863 99.8904  . 0.256 . . 0.252 . . . . . 0.246 . 20 . 0.961 0.930 0.342 
'X-RAY DIFFRACTION' 2.863  2.963  893  . 51 841 99.8880  . 0.252 . . 0.248 . . . . . 0.242 . 20 . 0.962 0.950 0.319 
'X-RAY DIFFRACTION' 2.963  3.074  865  . 59 806 100.0000 . 0.256 . . 0.253 . . . . . 0.246 . 20 . 0.965 0.953 0.297 
'X-RAY DIFFRACTION' 3.074  3.199  832  . 54 775 99.6394  . 0.236 . . 0.230 . . . . . 0.228 . 20 . 0.971 0.942 0.322 
'X-RAY DIFFRACTION' 3.199  3.341  792  . 45 746 99.8737  . 0.229 . . 0.227 . . . . . 0.234 . 20 . 0.973 0.950 0.269 
'X-RAY DIFFRACTION' 3.341  3.503  756  . 54 697 99.3386  . 0.253 . . 0.248 . . . . . 0.253 . 20 . 0.965 0.939 0.328 
'X-RAY DIFFRACTION' 3.503  3.692  710  . 19 685 99.1549  . 0.230 . . 0.226 . . . . . 0.239 . 20 . 0.973 0.941 0.358 
'X-RAY DIFFRACTION' 3.692  3.914  700  . 29 664 99.0000  . 0.220 . . 0.219 . . . . . 0.241 . 20 . 0.976 0.960 0.239 
'X-RAY DIFFRACTION' 3.914  4.183  643  . 48 588 98.9114  . 0.213 . . 0.210 . . . . . 0.237 . 20 . 0.976 0.969 0.248 
'X-RAY DIFFRACTION' 4.183  4.515  609  . 19 585 99.1790  . 0.186 . . 0.186 . . . . . 0.219 . 20 . 0.981 0.984 0.162 
'X-RAY DIFFRACTION' 4.515  4.942  548  . 15 527 98.9051  . 0.185 . . 0.181 . . . . . 0.224 . 20 . 0.983 0.977 0.417 
'X-RAY DIFFRACTION' 4.942  5.519  504  . 35 467 99.6032  . 0.229 . . 0.222 . . . . . 0.270 . 20 . 0.977 0.954 0.321 
'X-RAY DIFFRACTION' 5.519  6.360  456  . 52 401 99.3421  . 0.297 . . 0.286 . . . . . 0.339 . 20 . 0.959 0.948 0.368 
'X-RAY DIFFRACTION' 6.360  7.759  377  . 24 351 99.4695  . 0.237 . . 0.241 . . . . . 0.310 . 20 . 0.973 0.983 0.184 
'X-RAY DIFFRACTION' 7.759  10.847 302  . 7  294 99.6689  . 0.188 . . 0.190 . . . . . 0.283 . 20 . 0.983 0.997 0.140 
'X-RAY DIFFRACTION' 10.847 50.741 184  . 14 168 98.9130  . 0.252 . . 0.252 . . . . . 0.327 . 20 . 0.956 0.962 0.240 
# 
loop_
_struct_ncs_dom.id 
_struct_ncs_dom.pdbx_ens_id 
_struct_ncs_dom.details 
1 1 A 
2 1 A 
# 
loop_
_struct_ncs_dom_lim.pdbx_ens_id 
_struct_ncs_dom_lim.dom_id 
_struct_ncs_dom_lim.pdbx_component_id 
_struct_ncs_dom_lim.beg_label_asym_id 
_struct_ncs_dom_lim.beg_label_comp_id 
_struct_ncs_dom_lim.beg_label_seq_id 
_struct_ncs_dom_lim.beg_label_alt_id 
_struct_ncs_dom_lim.end_label_asym_id 
_struct_ncs_dom_lim.end_label_comp_id 
_struct_ncs_dom_lim.end_label_seq_id 
_struct_ncs_dom_lim.end_label_alt_id 
_struct_ncs_dom_lim.beg_auth_asym_id 
_struct_ncs_dom_lim.beg_auth_comp_id 
_struct_ncs_dom_lim.beg_auth_seq_id 
_struct_ncs_dom_lim.end_auth_asym_id 
_struct_ncs_dom_lim.end_auth_comp_id 
_struct_ncs_dom_lim.end_auth_seq_id 
_struct_ncs_dom_lim.pdbx_refine_code 
_struct_ncs_dom_lim.selection_details 
1 1 1 A LYS 1 . A GLU 192 . A LYS 1 A GLU 192 ? ? 
1 2 1 A LYS 1 . A GLU 192 . A LYS 1 A GLU 192 ? ? 
# 
_struct_ncs_ens.id        1 
_struct_ncs_ens.details   'Local NCS retraints between domains:       1       2' 
# 
_struct.entry_id                     8ZLF 
_struct.title                        
'Crystal structure of DH domain of FYVE Domain containing protein(FP10) from Entamoeba histolytica' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZLF 
_struct_keywords.text            'DH domain, GTPase Activator, cytoskeleton Modulator, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    N9UU15_ENTH1 
_struct_ref.pdbx_db_accession          N9UU15 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;KEDYRERIVNEMFDTEKSYVNSMEICIKGYYEPLIQSGHSVAPADKVNAVFLHFQSVLSINKELLKNMTELKEKGELSTR
LGEAFSQFIPMMNVYKLFLGNSDTSLQFLVELEKSSKFNDILDLLRSHLPGDNQLDLRSYLIMPVQRLPRYKLLLTDLIK
HTDDDFVDKPKLIDALDKISKLATLVNEVIKERSRNQKLLELVDKIEGL
;
_struct_ref.pdbx_align_begin           121 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZLF A 1 ? 209 ? N9UU15 121 ? 329 ? 1 209 
2 1 8ZLF B 1 ? 209 ? N9UU15 121 ? 329 ? 1 209 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LYS A 1   ? TYR A 30  ? LYS A 1   TYR A 30  1 ? 30 
HELX_P HELX_P2  AA2 TYR A 30  ? GLY A 38  ? TYR A 30  GLY A 38  1 ? 9  
HELX_P HELX_P3  AA3 PRO A 43  ? LEU A 52  ? PRO A 43  LEU A 52  1 ? 10 
HELX_P HELX_P4  AA4 HIS A 53  ? LYS A 74  ? HIS A 53  LYS A 74  1 ? 22 
HELX_P HELX_P5  AA5 GLU A 76  ? ILE A 89  ? GLU A 76  ILE A 89  1 ? 14 
HELX_P HELX_P6  AA6 MET A 92  ? ASN A 101 ? MET A 92  ASN A 101 1 ? 10 
HELX_P HELX_P7  AA7 ASN A 101 ? GLU A 113 ? ASN A 101 GLU A 113 1 ? 13 
HELX_P HELX_P8  AA8 SER A 115 ? HIS A 128 ? SER A 115 HIS A 128 1 ? 14 
HELX_P HELX_P9  AA9 ASP A 136 ? ILE A 142 ? ASP A 136 ILE A 142 1 ? 7  
HELX_P HELX_P10 AB1 ILE A 142 ? HIS A 161 ? ILE A 142 HIS A 161 1 ? 20 
HELX_P HELX_P11 AB2 ASP A 168 ? THR A 184 ? ASP A 168 THR A 184 1 ? 17 
HELX_P HELX_P12 AB3 GLU B 2   ? TYR B 30  ? GLU B 2   TYR B 30  1 ? 29 
HELX_P HELX_P13 AB4 TYR B 30  ? SER B 37  ? TYR B 30  SER B 37  1 ? 8  
HELX_P HELX_P14 AB5 GLY B 38  ? ALA B 42  ? GLY B 38  ALA B 42  5 ? 5  
HELX_P HELX_P15 AB6 PRO B 43  ? LEU B 52  ? PRO B 43  LEU B 52  1 ? 10 
HELX_P HELX_P16 AB7 HIS B 53  ? LYS B 74  ? HIS B 53  LYS B 74  1 ? 22 
HELX_P HELX_P17 AB8 GLU B 76  ? ILE B 89  ? GLU B 76  ILE B 89  1 ? 14 
HELX_P HELX_P18 AB9 MET B 92  ? GLU B 113 ? MET B 92  GLU B 113 1 ? 22 
HELX_P HELX_P19 AC1 SER B 115 ? HIS B 128 ? SER B 115 HIS B 128 1 ? 14 
HELX_P HELX_P20 AC2 ASP B 136 ? ILE B 142 ? ASP B 136 ILE B 142 1 ? 7  
HELX_P HELX_P21 AC3 ILE B 142 ? HIS B 161 ? ILE B 142 HIS B 161 1 ? 20 
HELX_P HELX_P22 AC4 ASP B 168 ? LYS B 181 ? ASP B 168 LYS B 181 1 ? 14 
HELX_P HELX_P23 AC5 THR B 184 ? LYS B 198 ? THR B 184 LYS B 198 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   8ZLF 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   ND1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   HIS 
_pdbx_validate_close_contact.auth_seq_id_1    39 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    301 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 GLU A 76  ? ? -141.17 28.23  
2 1 HIS B 53  ? ? 80.02   20.95  
3 1 LEU B 182 ? ? -102.24 50.92  
4 1 LEU B 202 ? ? -132.03 -87.24 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 80  ? ? 0.080 'SIDE CHAIN' 
2 1 ARG A 126 ? ? 0.080 'SIDE CHAIN' 
3 1 ARG A 193 ? ? 0.120 'SIDE CHAIN' 
4 1 ARG B 7   ? ? 0.099 'SIDE CHAIN' 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 342 ? 6.44 . 
2 1 O ? A HOH 343 ? 7.65 . 
3 1 O ? B HOH 434 ? 6.62 . 
4 1 O ? B HOH 435 ? 7.88 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A SER 194 ? A SER 194 
2  1 Y 1 A ARG 195 ? A ARG 195 
3  1 Y 1 A ASN 196 ? A ASN 196 
4  1 Y 1 A GLN 197 ? A GLN 197 
5  1 Y 1 A LYS 198 ? A LYS 198 
6  1 Y 1 A LEU 199 ? A LEU 199 
7  1 Y 1 A LEU 200 ? A LEU 200 
8  1 Y 1 A GLU 201 ? A GLU 201 
9  1 Y 1 A LEU 202 ? A LEU 202 
10 1 Y 1 A VAL 203 ? A VAL 203 
11 1 Y 1 A ASP 204 ? A ASP 204 
12 1 Y 1 A LYS 205 ? A LYS 205 
13 1 Y 1 A ILE 206 ? A ILE 206 
14 1 Y 1 A GLU 207 ? A GLU 207 
15 1 Y 1 A GLY 208 ? A GLY 208 
16 1 Y 1 A LEU 209 ? A LEU 209 
17 1 Y 1 B ASP 204 ? B ASP 204 
18 1 Y 1 B LYS 205 ? B LYS 205 
19 1 Y 1 B ILE 206 ? B ILE 206 
20 1 Y 1 B GLU 207 ? B GLU 207 
21 1 Y 1 B GLY 208 ? B GLY 208 
22 1 Y 1 B LEU 209 ? B LEU 209 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CIT C1   C N N 74  
CIT O1   O N N 75  
CIT O2   O N N 76  
CIT C2   C N N 77  
CIT C3   C N N 78  
CIT O7   O N N 79  
CIT C4   C N N 80  
CIT C5   C N N 81  
CIT O3   O N N 82  
CIT O4   O N N 83  
CIT C6   C N N 84  
CIT O5   O N N 85  
CIT O6   O N N 86  
CIT HO2  H N N 87  
CIT H21  H N N 88  
CIT H22  H N N 89  
CIT HO7  H N N 90  
CIT H41  H N N 91  
CIT H42  H N N 92  
CIT HO4  H N N 93  
CIT HO6  H N N 94  
CYS N    N N N 95  
CYS CA   C N R 96  
CYS C    C N N 97  
CYS O    O N N 98  
CYS CB   C N N 99  
CYS SG   S N N 100 
CYS OXT  O N N 101 
CYS H    H N N 102 
CYS H2   H N N 103 
CYS HA   H N N 104 
CYS HB2  H N N 105 
CYS HB3  H N N 106 
CYS HG   H N N 107 
CYS HXT  H N N 108 
GLN N    N N N 109 
GLN CA   C N S 110 
GLN C    C N N 111 
GLN O    O N N 112 
GLN CB   C N N 113 
GLN CG   C N N 114 
GLN CD   C N N 115 
GLN OE1  O N N 116 
GLN NE2  N N N 117 
GLN OXT  O N N 118 
GLN H    H N N 119 
GLN H2   H N N 120 
GLN HA   H N N 121 
GLN HB2  H N N 122 
GLN HB3  H N N 123 
GLN HG2  H N N 124 
GLN HG3  H N N 125 
GLN HE21 H N N 126 
GLN HE22 H N N 127 
GLN HXT  H N N 128 
GLU N    N N N 129 
GLU CA   C N S 130 
GLU C    C N N 131 
GLU O    O N N 132 
GLU CB   C N N 133 
GLU CG   C N N 134 
GLU CD   C N N 135 
GLU OE1  O N N 136 
GLU OE2  O N N 137 
GLU OXT  O N N 138 
GLU H    H N N 139 
GLU H2   H N N 140 
GLU HA   H N N 141 
GLU HB2  H N N 142 
GLU HB3  H N N 143 
GLU HG2  H N N 144 
GLU HG3  H N N 145 
GLU HE2  H N N 146 
GLU HXT  H N N 147 
GLY N    N N N 148 
GLY CA   C N N 149 
GLY C    C N N 150 
GLY O    O N N 151 
GLY OXT  O N N 152 
GLY H    H N N 153 
GLY H2   H N N 154 
GLY HA2  H N N 155 
GLY HA3  H N N 156 
GLY HXT  H N N 157 
HIS N    N N N 158 
HIS CA   C N S 159 
HIS C    C N N 160 
HIS O    O N N 161 
HIS CB   C N N 162 
HIS CG   C Y N 163 
HIS ND1  N Y N 164 
HIS CD2  C Y N 165 
HIS CE1  C Y N 166 
HIS NE2  N Y N 167 
HIS OXT  O N N 168 
HIS H    H N N 169 
HIS H2   H N N 170 
HIS HA   H N N 171 
HIS HB2  H N N 172 
HIS HB3  H N N 173 
HIS HD1  H N N 174 
HIS HD2  H N N 175 
HIS HE1  H N N 176 
HIS HE2  H N N 177 
HIS HXT  H N N 178 
HOH O    O N N 179 
HOH H1   H N N 180 
HOH H2   H N N 181 
ILE N    N N N 182 
ILE CA   C N S 183 
ILE C    C N N 184 
ILE O    O N N 185 
ILE CB   C N S 186 
ILE CG1  C N N 187 
ILE CG2  C N N 188 
ILE CD1  C N N 189 
ILE OXT  O N N 190 
ILE H    H N N 191 
ILE H2   H N N 192 
ILE HA   H N N 193 
ILE HB   H N N 194 
ILE HG12 H N N 195 
ILE HG13 H N N 196 
ILE HG21 H N N 197 
ILE HG22 H N N 198 
ILE HG23 H N N 199 
ILE HD11 H N N 200 
ILE HD12 H N N 201 
ILE HD13 H N N 202 
ILE HXT  H N N 203 
LEU N    N N N 204 
LEU CA   C N S 205 
LEU C    C N N 206 
LEU O    O N N 207 
LEU CB   C N N 208 
LEU CG   C N N 209 
LEU CD1  C N N 210 
LEU CD2  C N N 211 
LEU OXT  O N N 212 
LEU H    H N N 213 
LEU H2   H N N 214 
LEU HA   H N N 215 
LEU HB2  H N N 216 
LEU HB3  H N N 217 
LEU HG   H N N 218 
LEU HD11 H N N 219 
LEU HD12 H N N 220 
LEU HD13 H N N 221 
LEU HD21 H N N 222 
LEU HD22 H N N 223 
LEU HD23 H N N 224 
LEU HXT  H N N 225 
LYS N    N N N 226 
LYS CA   C N S 227 
LYS C    C N N 228 
LYS O    O N N 229 
LYS CB   C N N 230 
LYS CG   C N N 231 
LYS CD   C N N 232 
LYS CE   C N N 233 
LYS NZ   N N N 234 
LYS OXT  O N N 235 
LYS H    H N N 236 
LYS H2   H N N 237 
LYS HA   H N N 238 
LYS HB2  H N N 239 
LYS HB3  H N N 240 
LYS HG2  H N N 241 
LYS HG3  H N N 242 
LYS HD2  H N N 243 
LYS HD3  H N N 244 
LYS HE2  H N N 245 
LYS HE3  H N N 246 
LYS HZ1  H N N 247 
LYS HZ2  H N N 248 
LYS HZ3  H N N 249 
LYS HXT  H N N 250 
MET N    N N N 251 
MET CA   C N S 252 
MET C    C N N 253 
MET O    O N N 254 
MET CB   C N N 255 
MET CG   C N N 256 
MET SD   S N N 257 
MET CE   C N N 258 
MET OXT  O N N 259 
MET H    H N N 260 
MET H2   H N N 261 
MET HA   H N N 262 
MET HB2  H N N 263 
MET HB3  H N N 264 
MET HG2  H N N 265 
MET HG3  H N N 266 
MET HE1  H N N 267 
MET HE2  H N N 268 
MET HE3  H N N 269 
MET HXT  H N N 270 
PHE N    N N N 271 
PHE CA   C N S 272 
PHE C    C N N 273 
PHE O    O N N 274 
PHE CB   C N N 275 
PHE CG   C Y N 276 
PHE CD1  C Y N 277 
PHE CD2  C Y N 278 
PHE CE1  C Y N 279 
PHE CE2  C Y N 280 
PHE CZ   C Y N 281 
PHE OXT  O N N 282 
PHE H    H N N 283 
PHE H2   H N N 284 
PHE HA   H N N 285 
PHE HB2  H N N 286 
PHE HB3  H N N 287 
PHE HD1  H N N 288 
PHE HD2  H N N 289 
PHE HE1  H N N 290 
PHE HE2  H N N 291 
PHE HZ   H N N 292 
PHE HXT  H N N 293 
PRO N    N N N 294 
PRO CA   C N S 295 
PRO C    C N N 296 
PRO O    O N N 297 
PRO CB   C N N 298 
PRO CG   C N N 299 
PRO CD   C N N 300 
PRO OXT  O N N 301 
PRO H    H N N 302 
PRO HA   H N N 303 
PRO HB2  H N N 304 
PRO HB3  H N N 305 
PRO HG2  H N N 306 
PRO HG3  H N N 307 
PRO HD2  H N N 308 
PRO HD3  H N N 309 
PRO HXT  H N N 310 
SER N    N N N 311 
SER CA   C N S 312 
SER C    C N N 313 
SER O    O N N 314 
SER CB   C N N 315 
SER OG   O N N 316 
SER OXT  O N N 317 
SER H    H N N 318 
SER H2   H N N 319 
SER HA   H N N 320 
SER HB2  H N N 321 
SER HB3  H N N 322 
SER HG   H N N 323 
SER HXT  H N N 324 
THR N    N N N 325 
THR CA   C N S 326 
THR C    C N N 327 
THR O    O N N 328 
THR CB   C N R 329 
THR OG1  O N N 330 
THR CG2  C N N 331 
THR OXT  O N N 332 
THR H    H N N 333 
THR H2   H N N 334 
THR HA   H N N 335 
THR HB   H N N 336 
THR HG1  H N N 337 
THR HG21 H N N 338 
THR HG22 H N N 339 
THR HG23 H N N 340 
THR HXT  H N N 341 
TYR N    N N N 342 
TYR CA   C N S 343 
TYR C    C N N 344 
TYR O    O N N 345 
TYR CB   C N N 346 
TYR CG   C Y N 347 
TYR CD1  C Y N 348 
TYR CD2  C Y N 349 
TYR CE1  C Y N 350 
TYR CE2  C Y N 351 
TYR CZ   C Y N 352 
TYR OH   O N N 353 
TYR OXT  O N N 354 
TYR H    H N N 355 
TYR H2   H N N 356 
TYR HA   H N N 357 
TYR HB2  H N N 358 
TYR HB3  H N N 359 
TYR HD1  H N N 360 
TYR HD2  H N N 361 
TYR HE1  H N N 362 
TYR HE2  H N N 363 
TYR HH   H N N 364 
TYR HXT  H N N 365 
VAL N    N N N 366 
VAL CA   C N S 367 
VAL C    C N N 368 
VAL O    O N N 369 
VAL CB   C N N 370 
VAL CG1  C N N 371 
VAL CG2  C N N 372 
VAL OXT  O N N 373 
VAL H    H N N 374 
VAL H2   H N N 375 
VAL HA   H N N 376 
VAL HB   H N N 377 
VAL HG11 H N N 378 
VAL HG12 H N N 379 
VAL HG13 H N N 380 
VAL HG21 H N N 381 
VAL HG22 H N N 382 
VAL HG23 H N N 383 
VAL HXT  H N N 384 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CIT C1  O1   doub N N 70  
CIT C1  O2   sing N N 71  
CIT C1  C2   sing N N 72  
CIT O2  HO2  sing N N 73  
CIT C2  C3   sing N N 74  
CIT C2  H21  sing N N 75  
CIT C2  H22  sing N N 76  
CIT C3  O7   sing N N 77  
CIT C3  C4   sing N N 78  
CIT C3  C6   sing N N 79  
CIT O7  HO7  sing N N 80  
CIT C4  C5   sing N N 81  
CIT C4  H41  sing N N 82  
CIT C4  H42  sing N N 83  
CIT C5  O3   doub N N 84  
CIT C5  O4   sing N N 85  
CIT O4  HO4  sing N N 86  
CIT C6  O5   doub N N 87  
CIT C6  O6   sing N N 88  
CIT O6  HO6  sing N N 89  
CYS N   CA   sing N N 90  
CYS N   H    sing N N 91  
CYS N   H2   sing N N 92  
CYS CA  C    sing N N 93  
CYS CA  CB   sing N N 94  
CYS CA  HA   sing N N 95  
CYS C   O    doub N N 96  
CYS C   OXT  sing N N 97  
CYS CB  SG   sing N N 98  
CYS CB  HB2  sing N N 99  
CYS CB  HB3  sing N N 100 
CYS SG  HG   sing N N 101 
CYS OXT HXT  sing N N 102 
GLN N   CA   sing N N 103 
GLN N   H    sing N N 104 
GLN N   H2   sing N N 105 
GLN CA  C    sing N N 106 
GLN CA  CB   sing N N 107 
GLN CA  HA   sing N N 108 
GLN C   O    doub N N 109 
GLN C   OXT  sing N N 110 
GLN CB  CG   sing N N 111 
GLN CB  HB2  sing N N 112 
GLN CB  HB3  sing N N 113 
GLN CG  CD   sing N N 114 
GLN CG  HG2  sing N N 115 
GLN CG  HG3  sing N N 116 
GLN CD  OE1  doub N N 117 
GLN CD  NE2  sing N N 118 
GLN NE2 HE21 sing N N 119 
GLN NE2 HE22 sing N N 120 
GLN OXT HXT  sing N N 121 
GLU N   CA   sing N N 122 
GLU N   H    sing N N 123 
GLU N   H2   sing N N 124 
GLU CA  C    sing N N 125 
GLU CA  CB   sing N N 126 
GLU CA  HA   sing N N 127 
GLU C   O    doub N N 128 
GLU C   OXT  sing N N 129 
GLU CB  CG   sing N N 130 
GLU CB  HB2  sing N N 131 
GLU CB  HB3  sing N N 132 
GLU CG  CD   sing N N 133 
GLU CG  HG2  sing N N 134 
GLU CG  HG3  sing N N 135 
GLU CD  OE1  doub N N 136 
GLU CD  OE2  sing N N 137 
GLU OE2 HE2  sing N N 138 
GLU OXT HXT  sing N N 139 
GLY N   CA   sing N N 140 
GLY N   H    sing N N 141 
GLY N   H2   sing N N 142 
GLY CA  C    sing N N 143 
GLY CA  HA2  sing N N 144 
GLY CA  HA3  sing N N 145 
GLY C   O    doub N N 146 
GLY C   OXT  sing N N 147 
GLY OXT HXT  sing N N 148 
HIS N   CA   sing N N 149 
HIS N   H    sing N N 150 
HIS N   H2   sing N N 151 
HIS CA  C    sing N N 152 
HIS CA  CB   sing N N 153 
HIS CA  HA   sing N N 154 
HIS C   O    doub N N 155 
HIS C   OXT  sing N N 156 
HIS CB  CG   sing N N 157 
HIS CB  HB2  sing N N 158 
HIS CB  HB3  sing N N 159 
HIS CG  ND1  sing Y N 160 
HIS CG  CD2  doub Y N 161 
HIS ND1 CE1  doub Y N 162 
HIS ND1 HD1  sing N N 163 
HIS CD2 NE2  sing Y N 164 
HIS CD2 HD2  sing N N 165 
HIS CE1 NE2  sing Y N 166 
HIS CE1 HE1  sing N N 167 
HIS NE2 HE2  sing N N 168 
HIS OXT HXT  sing N N 169 
HOH O   H1   sing N N 170 
HOH O   H2   sing N N 171 
ILE N   CA   sing N N 172 
ILE N   H    sing N N 173 
ILE N   H2   sing N N 174 
ILE CA  C    sing N N 175 
ILE CA  CB   sing N N 176 
ILE CA  HA   sing N N 177 
ILE C   O    doub N N 178 
ILE C   OXT  sing N N 179 
ILE CB  CG1  sing N N 180 
ILE CB  CG2  sing N N 181 
ILE CB  HB   sing N N 182 
ILE CG1 CD1  sing N N 183 
ILE CG1 HG12 sing N N 184 
ILE CG1 HG13 sing N N 185 
ILE CG2 HG21 sing N N 186 
ILE CG2 HG22 sing N N 187 
ILE CG2 HG23 sing N N 188 
ILE CD1 HD11 sing N N 189 
ILE CD1 HD12 sing N N 190 
ILE CD1 HD13 sing N N 191 
ILE OXT HXT  sing N N 192 
LEU N   CA   sing N N 193 
LEU N   H    sing N N 194 
LEU N   H2   sing N N 195 
LEU CA  C    sing N N 196 
LEU CA  CB   sing N N 197 
LEU CA  HA   sing N N 198 
LEU C   O    doub N N 199 
LEU C   OXT  sing N N 200 
LEU CB  CG   sing N N 201 
LEU CB  HB2  sing N N 202 
LEU CB  HB3  sing N N 203 
LEU CG  CD1  sing N N 204 
LEU CG  CD2  sing N N 205 
LEU CG  HG   sing N N 206 
LEU CD1 HD11 sing N N 207 
LEU CD1 HD12 sing N N 208 
LEU CD1 HD13 sing N N 209 
LEU CD2 HD21 sing N N 210 
LEU CD2 HD22 sing N N 211 
LEU CD2 HD23 sing N N 212 
LEU OXT HXT  sing N N 213 
LYS N   CA   sing N N 214 
LYS N   H    sing N N 215 
LYS N   H2   sing N N 216 
LYS CA  C    sing N N 217 
LYS CA  CB   sing N N 218 
LYS CA  HA   sing N N 219 
LYS C   O    doub N N 220 
LYS C   OXT  sing N N 221 
LYS CB  CG   sing N N 222 
LYS CB  HB2  sing N N 223 
LYS CB  HB3  sing N N 224 
LYS CG  CD   sing N N 225 
LYS CG  HG2  sing N N 226 
LYS CG  HG3  sing N N 227 
LYS CD  CE   sing N N 228 
LYS CD  HD2  sing N N 229 
LYS CD  HD3  sing N N 230 
LYS CE  NZ   sing N N 231 
LYS CE  HE2  sing N N 232 
LYS CE  HE3  sing N N 233 
LYS NZ  HZ1  sing N N 234 
LYS NZ  HZ2  sing N N 235 
LYS NZ  HZ3  sing N N 236 
LYS OXT HXT  sing N N 237 
MET N   CA   sing N N 238 
MET N   H    sing N N 239 
MET N   H2   sing N N 240 
MET CA  C    sing N N 241 
MET CA  CB   sing N N 242 
MET CA  HA   sing N N 243 
MET C   O    doub N N 244 
MET C   OXT  sing N N 245 
MET CB  CG   sing N N 246 
MET CB  HB2  sing N N 247 
MET CB  HB3  sing N N 248 
MET CG  SD   sing N N 249 
MET CG  HG2  sing N N 250 
MET CG  HG3  sing N N 251 
MET SD  CE   sing N N 252 
MET CE  HE1  sing N N 253 
MET CE  HE2  sing N N 254 
MET CE  HE3  sing N N 255 
MET OXT HXT  sing N N 256 
PHE N   CA   sing N N 257 
PHE N   H    sing N N 258 
PHE N   H2   sing N N 259 
PHE CA  C    sing N N 260 
PHE CA  CB   sing N N 261 
PHE CA  HA   sing N N 262 
PHE C   O    doub N N 263 
PHE C   OXT  sing N N 264 
PHE CB  CG   sing N N 265 
PHE CB  HB2  sing N N 266 
PHE CB  HB3  sing N N 267 
PHE CG  CD1  doub Y N 268 
PHE CG  CD2  sing Y N 269 
PHE CD1 CE1  sing Y N 270 
PHE CD1 HD1  sing N N 271 
PHE CD2 CE2  doub Y N 272 
PHE CD2 HD2  sing N N 273 
PHE CE1 CZ   doub Y N 274 
PHE CE1 HE1  sing N N 275 
PHE CE2 CZ   sing Y N 276 
PHE CE2 HE2  sing N N 277 
PHE CZ  HZ   sing N N 278 
PHE OXT HXT  sing N N 279 
PRO N   CA   sing N N 280 
PRO N   CD   sing N N 281 
PRO N   H    sing N N 282 
PRO CA  C    sing N N 283 
PRO CA  CB   sing N N 284 
PRO CA  HA   sing N N 285 
PRO C   O    doub N N 286 
PRO C   OXT  sing N N 287 
PRO CB  CG   sing N N 288 
PRO CB  HB2  sing N N 289 
PRO CB  HB3  sing N N 290 
PRO CG  CD   sing N N 291 
PRO CG  HG2  sing N N 292 
PRO CG  HG3  sing N N 293 
PRO CD  HD2  sing N N 294 
PRO CD  HD3  sing N N 295 
PRO OXT HXT  sing N N 296 
SER N   CA   sing N N 297 
SER N   H    sing N N 298 
SER N   H2   sing N N 299 
SER CA  C    sing N N 300 
SER CA  CB   sing N N 301 
SER CA  HA   sing N N 302 
SER C   O    doub N N 303 
SER C   OXT  sing N N 304 
SER CB  OG   sing N N 305 
SER CB  HB2  sing N N 306 
SER CB  HB3  sing N N 307 
SER OG  HG   sing N N 308 
SER OXT HXT  sing N N 309 
THR N   CA   sing N N 310 
THR N   H    sing N N 311 
THR N   H2   sing N N 312 
THR CA  C    sing N N 313 
THR CA  CB   sing N N 314 
THR CA  HA   sing N N 315 
THR C   O    doub N N 316 
THR C   OXT  sing N N 317 
THR CB  OG1  sing N N 318 
THR CB  CG2  sing N N 319 
THR CB  HB   sing N N 320 
THR OG1 HG1  sing N N 321 
THR CG2 HG21 sing N N 322 
THR CG2 HG22 sing N N 323 
THR CG2 HG23 sing N N 324 
THR OXT HXT  sing N N 325 
TYR N   CA   sing N N 326 
TYR N   H    sing N N 327 
TYR N   H2   sing N N 328 
TYR CA  C    sing N N 329 
TYR CA  CB   sing N N 330 
TYR CA  HA   sing N N 331 
TYR C   O    doub N N 332 
TYR C   OXT  sing N N 333 
TYR CB  CG   sing N N 334 
TYR CB  HB2  sing N N 335 
TYR CB  HB3  sing N N 336 
TYR CG  CD1  doub Y N 337 
TYR CG  CD2  sing Y N 338 
TYR CD1 CE1  sing Y N 339 
TYR CD1 HD1  sing N N 340 
TYR CD2 CE2  doub Y N 341 
TYR CD2 HD2  sing N N 342 
TYR CE1 CZ   doub Y N 343 
TYR CE1 HE1  sing N N 344 
TYR CE2 CZ   sing Y N 345 
TYR CE2 HE2  sing N N 346 
TYR CZ  OH   sing N N 347 
TYR OH  HH   sing N N 348 
TYR OXT HXT  sing N N 349 
VAL N   CA   sing N N 350 
VAL N   H    sing N N 351 
VAL N   H2   sing N N 352 
VAL CA  C    sing N N 353 
VAL CA  CB   sing N N 354 
VAL CA  HA   sing N N 355 
VAL C   O    doub N N 356 
VAL C   OXT  sing N N 357 
VAL CB  CG1  sing N N 358 
VAL CB  CG2  sing N N 359 
VAL CB  HB   sing N N 360 
VAL CG1 HG11 sing N N 361 
VAL CG1 HG12 sing N N 362 
VAL CG1 HG13 sing N N 363 
VAL CG2 HG21 sing N N 364 
VAL CG2 HG22 sing N N 365 
VAL CG2 HG23 sing N N 366 
VAL OXT HXT  sing N N 367 
# 
_pdbx_audit_support.funding_organization   'Science and Engineering Research Board (SERB)' 
_pdbx_audit_support.country                India 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8ZLF 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017671 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.009505 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014422 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019708 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0475   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . LYS A 1 1   ? 33.229  6.889   25.776 1.000 41.897  0 1   LYS A N   1 ? 
ATOM   2    C CA  . LYS A 1 1   ? 32.583  7.551   24.603 1.000 41.121  0 1   LYS A CA  1 ? 
ATOM   3    C C   . LYS A 1 1   ? 32.362  6.539   23.475 1.000 40.565  0 1   LYS A C   1 ? 
ATOM   4    O O   . LYS A 1 1   ? 31.323  6.558   22.827 1.000 35.309  0 1   LYS A O   1 ? 
ATOM   5    C CB  . LYS A 1 1   ? 33.409  8.752   24.125 1.000 40.630  0 1   LYS A CB  1 ? 
ATOM   6    C CG  . LYS A 1 1   ? 32.704  9.706   23.162 1.000 37.200  0 1   LYS A CG  1 ? 
ATOM   7    N N   . GLU A 1 2   ? 33.316  5.628   23.251 1.000 38.596  0 2   GLU A N   1 ? 
ATOM   8    C CA  . GLU A 1 2   ? 33.131  4.558   22.279 1.000 40.339  0 2   GLU A CA  1 ? 
ATOM   9    C C   . GLU A 1 2   ? 32.007  3.640   22.730 1.000 40.976  0 2   GLU A C   1 ? 
ATOM   10   O O   . GLU A 1 2   ? 31.260  3.115   21.904 1.000 48.508  0 2   GLU A O   1 ? 
ATOM   11   C CB  . GLU A 1 2   ? 34.397  3.720   22.081 1.000 42.957  0 2   GLU A CB  1 ? 
ATOM   12   N N   . ASP A 1 3   ? 31.895  3.446   24.049 1.000 41.993  0 3   ASP A N   1 ? 
ATOM   13   C CA  . ASP A 1 3   ? 30.960  2.476   24.593 1.000 41.230  0 3   ASP A CA  1 ? 
ATOM   14   C C   . ASP A 1 3   ? 29.575  3.109   24.701 1.000 35.933  0 3   ASP A C   1 ? 
ATOM   15   O O   . ASP A 1 3   ? 28.580  2.411   24.654 1.000 37.180  0 3   ASP A O   1 ? 
ATOM   16   C CB  . ASP A 1 3   ? 31.495  1.885   25.896 1.000 48.952  0 3   ASP A CB  1 ? 
ATOM   17   C CG  . ASP A 1 3   ? 32.729  1.006   25.705 1.000 62.380  0 3   ASP A CG  1 ? 
ATOM   18   O OD1 . ASP A 1 3   ? 32.572  -0.167  25.277 1.000 59.756  0 3   ASP A OD1 1 ? 
ATOM   19   O OD2 . ASP A 1 3   ? 33.851  1.503   25.957 1.000 71.724  0 3   ASP A OD2 1 ? 
ATOM   20   N N   . TYR A 1 4   ? 29.498  4.433   24.806 1.000 34.324  0 4   TYR A N   1 ? 
ATOM   21   C CA  . TYR A 1 4   ? 28.228  5.122   24.684 1.000 29.882  0 4   TYR A CA  1 ? 
ATOM   22   C C   . TYR A 1 4   ? 27.668  4.911   23.287 1.000 33.165  0 4   TYR A C   1 ? 
ATOM   23   O O   . TYR A 1 4   ? 26.472  4.667   23.103 1.000 41.500  0 4   TYR A O   1 ? 
ATOM   24   C CB  . TYR A 1 4   ? 28.422  6.615   24.945 1.000 29.231  0 4   TYR A CB  1 ? 
ATOM   25   C CG  . TYR A 1 4   ? 27.178  7.449   24.837 1.000 32.480  0 4   TYR A CG  1 ? 
ATOM   26   C CD1 . TYR A 1 4   ? 26.198  7.428   25.813 1.000 33.240  0 4   TYR A CD1 1 ? 
ATOM   27   C CD2 . TYR A 1 4   ? 26.942  8.206   23.718 1.000 36.023  0 4   TYR A CD2 1 ? 
ATOM   28   C CE1 . TYR A 1 4   ? 25.049  8.196   25.716 1.000 33.056  0 4   TYR A CE1 1 ? 
ATOM   29   C CE2 . TYR A 1 4   ? 25.796  8.975   23.599 1.000 39.574  0 4   TYR A CE2 1 ? 
ATOM   30   C CZ  . TYR A 1 4   ? 24.851  8.985   24.604 1.000 37.360  0 4   TYR A CZ  1 ? 
ATOM   31   O OH  . TYR A 1 4   ? 23.733  9.763   24.442 1.000 42.075  0 4   TYR A OH  1 ? 
ATOM   32   N N   . ARG A 1 5   ? 28.556  5.057   22.302 1.000 35.988  0 5   ARG A N   1 ? 
ATOM   33   C CA  . ARG A 1 5   ? 28.223  4.914   20.892 1.000 37.434  0 5   ARG A CA  1 ? 
ATOM   34   C C   . ARG A 1 5   ? 27.667  3.510   20.655 1.000 37.285  0 5   ARG A C   1 ? 
ATOM   35   O O   . ARG A 1 5   ? 26.596  3.347   20.065 1.000 36.013  0 5   ARG A O   1 ? 
ATOM   36   C CB  . ARG A 1 5   ? 29.483  5.203   20.063 1.000 39.580  0 5   ARG A CB  1 ? 
ATOM   37   C CG  . ARG A 1 5   ? 29.275  5.377   18.566 1.000 39.841  0 5   ARG A CG  1 ? 
ATOM   38   C CD  . ARG A 1 5   ? 30.564  5.613   17.803 1.000 35.511  0 5   ARG A CD  1 ? 
ATOM   39   N NE  . ARG A 1 5   ? 30.261  5.887   16.399 1.000 37.096  0 5   ARG A NE  1 ? 
ATOM   40   C CZ  . ARG A 1 5   ? 29.913  4.978   15.491 1.000 37.257  0 5   ARG A CZ  1 ? 
ATOM   41   N NH1 . ARG A 1 5   ? 30.031  3.680   15.729 1.000 34.325  0 5   ARG A NH1 1 ? 
ATOM   42   N NH2 . ARG A 1 5   ? 29.500  5.376   14.303 1.000 41.711  0 5   ARG A NH2 1 ? 
ATOM   43   N N   . GLU A 1 6   ? 28.397  2.509   21.149 1.000 37.197  0 6   GLU A N   1 ? 
ATOM   44   C CA  . GLU A 1 6   ? 27.995  1.127   20.986 1.000 43.009  0 6   GLU A CA  1 ? 
ATOM   45   C C   . GLU A 1 6   ? 26.532  0.952   21.402 1.000 41.800  0 6   GLU A C   1 ? 
ATOM   46   O O   . GLU A 1 6   ? 25.757  0.310   20.689 1.000 47.134  0 6   GLU A O   1 ? 
ATOM   47   C CB  . GLU A 1 6   ? 28.946  0.202   21.750 1.000 49.139  0 6   GLU A CB  1 ? 
ATOM   48   C CG  . GLU A 1 6   ? 29.216  -1.091  20.998 1.000 59.165  0 6   GLU A CG  1 ? 
ATOM   49   C CD  . GLU A 1 6   ? 30.217  -0.964  19.851 1.000 71.988  0 6   GLU A CD  1 ? 
ATOM   50   O OE1 . GLU A 1 6   ? 30.139  0.023   19.094 1.000 81.296  0 6   GLU A OE1 1 ? 
ATOM   51   O OE2 . GLU A 1 6   ? 31.069  -1.869  19.674 1.000 84.291  0 6   GLU A OE2 1 ? 
ATOM   52   N N   . ARG A 1 7   ? 26.143  1.556   22.532 1.000 38.915  0 7   ARG A N   1 ? 
ATOM   53   C CA  . ARG A 1 7   ? 24.782  1.452   23.041 1.000 39.539  0 7   ARG A CA  1 ? 
ATOM   54   C C   . ARG A 1 7   ? 23.758  1.874   21.983 1.000 38.320  0 7   ARG A C   1 ? 
ATOM   55   O O   . ARG A 1 7   ? 22.838  1.135   21.655 1.000 32.832  0 7   ARG A O   1 ? 
ATOM   56   C CB  . ARG A 1 7   ? 24.599  2.346   24.272 1.000 42.893  0 7   ARG A CB  1 ? 
ATOM   57   C CG  . ARG A 1 7   ? 24.935  1.683   25.593 1.000 47.592  0 7   ARG A CG  1 ? 
ATOM   58   C CD  . ARG A 1 7   ? 24.285  2.406   26.764 1.000 50.538  0 7   ARG A CD  1 ? 
ATOM   59   N NE  . ARG A 1 7   ? 22.925  1.953   27.048 1.000 49.449  0 7   ARG A NE  1 ? 
ATOM   60   C CZ  . ARG A 1 7   ? 21.916  2.744   27.410 1.000 58.086  0 7   ARG A CZ  1 ? 
ATOM   61   N NH1 . ARG A 1 7   ? 20.803  2.218   27.903 1.000 56.601  0 7   ARG A NH1 1 ? 
ATOM   62   N NH2 . ARG A 1 7   ? 22.050  4.062   27.349 1.000 58.242  0 7   ARG A NH2 1 ? 
ATOM   63   N N   . ILE A 1 8   ? 23.919  3.089   21.456 1.000 39.176  0 8   ILE A N   1 ? 
ATOM   64   C CA  . ILE A 1 8   ? 23.019  3.626   20.449 1.000 36.607  0 8   ILE A CA  1 ? 
ATOM   65   C C   . ILE A 1 8   ? 22.922  2.679   19.266 1.000 32.884  0 8   ILE A C   1 ? 
ATOM   66   O O   . ILE A 1 8   ? 21.834  2.360   18.833 1.000 38.407  0 8   ILE A O   1 ? 
ATOM   67   C CB  . ILE A 1 8   ? 23.492  5.010   19.988 1.000 35.135  0 8   ILE A CB  1 ? 
ATOM   68   C CG1 . ILE A 1 8   ? 23.471  5.996   21.152 1.000 37.739  0 8   ILE A CG1 1 ? 
ATOM   69   C CG2 . ILE A 1 8   ? 22.662  5.496   18.818 1.000 32.647  0 8   ILE A CG2 1 ? 
ATOM   70   C CD1 . ILE A 1 8   ? 24.330  7.184   20.905 1.000 43.706  0 8   ILE A CD1 1 ? 
ATOM   71   N N   . VAL A 1 9   ? 24.063  2.256   18.729 1.000 39.600  0 9   VAL A N   1 ? 
ATOM   72   C CA  . VAL A 1 9   ? 24.076  1.284   17.644 1.000 37.541  0 9   VAL A CA  1 ? 
ATOM   73   C C   . VAL A 1 9   ? 23.177  0.113   18.039 1.000 37.094  0 9   VAL A C   1 ? 
ATOM   74   O O   . VAL A 1 9   ? 22.260  -0.219  17.314 1.000 42.566  0 9   VAL A O   1 ? 
ATOM   75   C CB  . VAL A 1 9   ? 25.507  0.841   17.278 1.000 34.364  0 9   VAL A CB  1 ? 
ATOM   76   C CG1 . VAL A 1 9   ? 25.514  -0.414  16.414 1.000 34.091  0 9   VAL A CG1 1 ? 
ATOM   77   C CG2 . VAL A 1 9   ? 26.307  1.964   16.612 1.000 32.340  0 9   VAL A CG2 1 ? 
ATOM   78   N N   . ASN A 1 10  ? 23.364  -0.437  19.236 1.000 39.375  0 10  ASN A N   1 ? 
ATOM   79   C CA  . ASN A 1 10  ? 22.634  -1.615  19.668 1.000 42.061  0 10  ASN A CA  1 ? 
ATOM   80   C C   . ASN A 1 10  ? 21.149  -1.330  19.860 1.000 39.809  0 10  ASN A C   1 ? 
ATOM   81   O O   . ASN A 1 10  ? 20.321  -2.199  19.595 1.000 32.000  0 10  ASN A O   1 ? 
ATOM   82   C CB  . ASN A 1 10  ? 23.281  -2.214  20.917 1.000 52.384  0 10  ASN A CB  1 ? 
ATOM   83   C CG  . ASN A 1 10  ? 24.636  -2.816  20.584 1.000 60.604  0 10  ASN A CG  1 ? 
ATOM   84   O OD1 . ASN A 1 10  ? 24.747  -3.618  19.650 1.000 52.779  0 10  ASN A OD1 1 ? 
ATOM   85   N ND2 . ASN A 1 10  ? 25.675  -2.410  21.305 1.000 67.994  0 10  ASN A ND2 1 ? 
ATOM   86   N N   . GLU A 1 11  ? 20.812  -0.113  20.293 1.000 41.312  0 11  GLU A N   1 ? 
ATOM   87   C CA  . GLU A 1 11  ? 19.423  0.262   20.490 1.000 43.709  0 11  GLU A CA  1 ? 
ATOM   88   C C   . GLU A 1 11  ? 18.732  0.280   19.136 1.000 45.616  0 11  GLU A C   1 ? 
ATOM   89   O O   . GLU A 1 11  ? 17.608  -0.219  19.004 1.000 41.150  0 11  GLU A O   1 ? 
ATOM   90   C CB  . GLU A 1 11  ? 19.297  1.620   21.196 1.000 51.506  0 11  GLU A CB  1 ? 
ATOM   91   C CG  . GLU A 1 11  ? 17.859  2.115   21.372 1.000 58.612  0 11  GLU A CG  1 ? 
ATOM   92   C CD  . GLU A 1 11  ? 17.575  3.190   22.425 1.000 66.774  0 11  GLU A CD  1 ? 
ATOM   93   O OE1 . GLU A 1 11  ? 18.520  3.619   23.166 1.000 73.682  0 11  GLU A OE1 1 ? 
ATOM   94   O OE2 . GLU A 1 11  ? 16.387  3.598   22.527 1.000 56.239  0 11  GLU A OE2 1 ? 
ATOM   95   N N   . MET A 1 12  ? 19.408  0.859   18.135 1.000 48.990  0 12  MET A N   1 ? 
ATOM   96   C CA  . MET A 1 12  ? 18.813  0.970   16.812 1.000 54.642  0 12  MET A CA  1 ? 
ATOM   97   C C   . MET A 1 12  ? 18.526  -0.431  16.290 1.000 45.923  0 12  MET A C   1 ? 
ATOM   98   O O   . MET A 1 12  ? 17.412  -0.716  15.849 1.000 40.817  0 12  MET A O   1 ? 
ATOM   99   C CB  . MET A 1 12  ? 19.716  1.694   15.813 1.000 63.483  0 12  MET A CB  1 ? 
ATOM   100  C CG  . MET A 1 12  ? 18.961  2.136   14.555 1.000 71.007  0 12  MET A CG  1 ? 
ATOM   101  S SD  . MET A 1 12  ? 19.227  3.900   14.151 1.000 91.574  0 12  MET A SD  1 ? 
ATOM   102  C CE  . MET A 1 12  ? 20.707  4.283   15.095 1.000 79.921  0 12  MET A CE  1 ? 
ATOM   103  N N   . PHE A 1 13  ? 19.533  -1.304  16.402 1.000 42.395  0 13  PHE A N   1 ? 
ATOM   104  C CA  . PHE A 1 13  ? 19.402  -2.675  15.953 1.000 39.404  0 13  PHE A CA  1 ? 
ATOM   105  C C   . PHE A 1 13  ? 18.251  -3.372  16.682 1.000 37.316  0 13  PHE A C   1 ? 
ATOM   106  O O   . PHE A 1 13  ? 17.439  -4.032  16.042 1.000 34.123  0 13  PHE A O   1 ? 
ATOM   107  C CB  . PHE A 1 13  ? 20.712  -3.437  16.133 1.000 35.692  0 13  PHE A CB  1 ? 
ATOM   108  C CG  . PHE A 1 13  ? 20.616  -4.831  15.583 1.000 40.541  0 13  PHE A CG  1 ? 
ATOM   109  C CD1 . PHE A 1 13  ? 20.836  -5.078  14.240 1.000 40.428  0 13  PHE A CD1 1 ? 
ATOM   110  C CD2 . PHE A 1 13  ? 20.161  -5.874  16.375 1.000 44.826  0 13  PHE A CD2 1 ? 
ATOM   111  C CE1 . PHE A 1 13  ? 20.697  -6.358  13.723 1.000 43.513  0 13  PHE A CE1 1 ? 
ATOM   112  C CE2 . PHE A 1 13  ? 20.021  -7.155  15.857 1.000 43.967  0 13  PHE A CE2 1 ? 
ATOM   113  C CZ  . PHE A 1 13  ? 20.306  -7.398  14.536 1.000 42.554  0 13  PHE A CZ  1 ? 
ATOM   114  N N   . ASP A 1 14  ? 18.187  -3.210  18.010 1.000 36.623  0 14  ASP A N   1 ? 
ATOM   115  C CA  . ASP A 1 14  ? 17.238  -3.947  18.831 1.000 42.422  0 14  ASP A CA  1 ? 
ATOM   116  C C   . ASP A 1 14  ? 15.821  -3.410  18.619 1.000 41.797  0 14  ASP A C   1 ? 
ATOM   117  O O   . ASP A 1 14  ? 14.860  -4.179  18.620 1.000 35.701  0 14  ASP A O   1 ? 
ATOM   118  C CB  . ASP A 1 14  ? 17.675  -3.962  20.303 1.000 49.816  0 14  ASP A CB  1 ? 
ATOM   119  C CG  . ASP A 1 14  ? 18.874  -4.870  20.625 1.000 62.567  0 14  ASP A CG  1 ? 
ATOM   120  O OD1 . ASP A 1 14  ? 19.342  -5.646  19.740 1.000 57.004  0 14  ASP A OD1 1 ? 
ATOM   121  O OD2 . ASP A 1 14  ? 19.359  -4.802  21.776 1.000 74.739  0 14  ASP A OD2 1 ? 
ATOM   122  N N   . THR A 1 15  ? 15.686  -2.092  18.414 1.000 41.480  0 15  THR A N   1 ? 
ATOM   123  C CA  . THR A 1 15  ? 14.382  -1.515  18.138 1.000 37.298  0 15  THR A CA  1 ? 
ATOM   124  C C   . THR A 1 15  ? 13.953  -1.771  16.697 1.000 36.997  0 15  THR A C   1 ? 
ATOM   125  O O   . THR A 1 15  ? 12.759  -1.709  16.422 1.000 40.340  0 15  THR A O   1 ? 
ATOM   126  C CB  . THR A 1 15  ? 14.316  -0.022  18.476 1.000 35.317  0 15  THR A CB  1 ? 
ATOM   127  O OG1 . THR A 1 15  ? 15.390  0.709   17.887 1.000 34.902  0 15  THR A OG1 1 ? 
ATOM   128  C CG2 . THR A 1 15  ? 14.330  0.198   19.971 1.000 38.131  0 15  THR A CG2 1 ? 
ATOM   129  N N   . GLU A 1 16  ? 14.894  -2.045  15.781 1.000 35.860  0 16  GLU A N   1 ? 
ATOM   130  C CA  . GLU A 1 16  ? 14.530  -2.376  14.408 1.000 38.038  0 16  GLU A CA  1 ? 
ATOM   131  C C   . GLU A 1 16  ? 13.949  -3.789  14.336 1.000 37.048  0 16  GLU A C   1 ? 
ATOM   132  O O   . GLU A 1 16  ? 12.865  -3.983  13.783 1.000 37.969  0 16  GLU A O   1 ? 
ATOM   133  C CB  . GLU A 1 16  ? 15.725  -2.298  13.457 1.000 43.850  0 16  GLU A CB  1 ? 
ATOM   134  C CG  . GLU A 1 16  ? 15.326  -2.404  11.994 1.000 48.985  0 16  GLU A CG  1 ? 
ATOM   135  C CD  . GLU A 1 16  ? 14.511  -1.227  11.457 1.000 56.671  0 16  GLU A CD  1 ? 
ATOM   136  O OE1 . GLU A 1 16  ? 14.591  -0.102  12.038 1.000 47.334  0 16  GLU A OE1 1 ? 
ATOM   137  O OE2 . GLU A 1 16  ? 13.784  -1.437  10.451 1.000 58.248  0 16  GLU A OE2 1 ? 
ATOM   138  N N   . LYS A 1 17  ? 14.691  -4.762  14.888 1.000 32.571  0 17  LYS A N   1 ? 
ATOM   139  C CA  . LYS A 1 17  ? 14.228  -6.133  14.976 1.000 32.938  0 17  LYS A CA  1 ? 
ATOM   140  C C   . LYS A 1 17  ? 12.852  -6.146  15.621 1.000 28.359  0 17  LYS A C   1 ? 
ATOM   141  O O   . LYS A 1 17  ? 11.965  -6.834  15.164 1.000 35.560  0 17  LYS A O   1 ? 
ATOM   142  C CB  . LYS A 1 17  ? 15.192  -7.017  15.780 1.000 35.173  0 17  LYS A CB  1 ? 
ATOM   143  N N   . SER A 1 18  ? 12.683  -5.399  16.694 1.000 28.368  0 18  SER A N   1 ? 
ATOM   144  C CA  . SER A 1 18  ? 11.424  -5.354  17.404 1.000 31.141  0 18  SER A CA  1 ? 
ATOM   145  C C   . SER A 1 18  ? 10.342  -4.854  16.449 1.000 35.844  0 18  SER A C   1 ? 
ATOM   146  O O   . SER A 1 18  ? 9.267   -5.430  16.341 1.000 39.039  0 18  SER A O   1 ? 
ATOM   147  C CB  . SER A 1 18  ? 11.590  -4.448  18.605 1.000 36.995  0 18  SER A CB  1 ? 
ATOM   148  O OG  . SER A 1 18  ? 10.515  -4.570  19.522 1.000 42.028  0 18  SER A OG  1 ? 
ATOM   149  N N   . TYR A 1 19  ? 10.690  -3.794  15.707 1.000 34.946  0 19  TYR A N   1 ? 
ATOM   150  C CA  . TYR A 1 19  ? 9.776   -3.083  14.837 1.000 31.188  0 19  TYR A CA  1 ? 
ATOM   151  C C   . TYR A 1 19  ? 9.339   -3.975  13.686 1.000 31.853  0 19  TYR A C   1 ? 
ATOM   152  O O   . TYR A 1 19  ? 8.145   -4.135  13.451 1.000 30.459  0 19  TYR A O   1 ? 
ATOM   153  C CB  . TYR A 1 19  ? 10.466  -1.822  14.330 1.000 28.939  0 19  TYR A CB  1 ? 
ATOM   154  C CG  . TYR A 1 19  ? 9.770   -1.043  13.253 1.000 27.567  0 19  TYR A CG  1 ? 
ATOM   155  C CD1 . TYR A 1 19  ? 8.416   -0.777  13.273 1.000 24.491  0 19  TYR A CD1 1 ? 
ATOM   156  C CD2 . TYR A 1 19  ? 10.513  -0.493  12.227 1.000 29.940  0 19  TYR A CD2 1 ? 
ATOM   157  C CE1 . TYR A 1 19  ? 7.816   -0.001  12.286 1.000 26.304  0 19  TYR A CE1 1 ? 
ATOM   158  C CE2 . TYR A 1 19  ? 9.934   0.303   11.249 1.000 29.336  0 19  TYR A CE2 1 ? 
ATOM   159  C CZ  . TYR A 1 19  ? 8.579   0.557   11.276 1.000 26.110  0 19  TYR A CZ  1 ? 
ATOM   160  O OH  . TYR A 1 19  ? 8.051   1.319   10.248 1.000 24.369  0 19  TYR A OH  1 ? 
ATOM   161  N N   . VAL A 1 20  ? 10.301  -4.543  12.967 1.000 30.186  0 20  VAL A N   1 ? 
ATOM   162  C CA  . VAL A 1 20  ? 9.950   -5.425  11.867 1.000 33.321  0 20  VAL A CA  1 ? 
ATOM   163  C C   . VAL A 1 20  ? 9.156   -6.620  12.397 1.000 32.013  0 20  VAL A C   1 ? 
ATOM   164  O O   . VAL A 1 20  ? 8.179   -7.008  11.772 1.000 33.646  0 20  VAL A O   1 ? 
ATOM   165  C CB  . VAL A 1 20  ? 11.183  -5.882  11.059 1.000 34.839  0 20  VAL A CB  1 ? 
ATOM   166  C CG1 . VAL A 1 20  ? 10.839  -6.960  10.047 1.000 34.832  0 20  VAL A CG1 1 ? 
ATOM   167  C CG2 . VAL A 1 20  ? 11.838  -4.718  10.351 1.000 33.812  0 20  VAL A CG2 1 ? 
ATOM   168  N N   . ASN A 1 21  ? 9.556   -7.190  13.538 1.000 28.804  0 21  ASN A N   1 ? 
ATOM   169  C CA  . ASN A 1 21  ? 8.856   -8.346  14.085 1.000 32.632  0 21  ASN A CA  1 ? 
ATOM   170  C C   . ASN A 1 21  ? 7.396   -7.986  14.380 1.000 32.602  0 21  ASN A C   1 ? 
ATOM   171  O O   . ASN A 1 21  ? 6.500   -8.753  14.023 1.000 29.025  0 21  ASN A O   1 ? 
ATOM   172  C CB  . ASN A 1 21  ? 9.579   -8.916  15.311 1.000 40.221  0 21  ASN A CB  1 ? 
ATOM   173  C CG  . ASN A 1 21  ? 8.766   -9.948  16.069 1.000 46.573  0 21  ASN A CG  1 ? 
ATOM   174  O OD1 . ASN A 1 21  ? 8.552   -11.050 15.568 1.000 47.007  0 21  ASN A OD1 1 ? 
ATOM   175  N ND2 . ASN A 1 21  ? 8.302   -9.609  17.266 1.000 41.648  0 21  ASN A ND2 1 ? 
ATOM   176  N N   . SER A 1 22  ? 7.148   -6.814  15.004 1.000 32.359  0 22  SER A N   1 ? 
ATOM   177  C CA  . SER A 1 22  ? 5.790   -6.403  15.322 1.000 27.656  0 22  SER A CA  1 ? 
ATOM   178  C C   . SER A 1 22  ? 4.996   -6.295  14.037 1.000 29.147  0 22  SER A C   1 ? 
ATOM   179  O O   . SER A 1 22  ? 3.838   -6.697  14.003 1.000 35.291  0 22  SER A O   1 ? 
ATOM   180  C CB  . SER A 1 22  ? 5.718   -5.095  16.055 1.000 28.378  0 22  SER A CB  1 ? 
ATOM   181  O OG  . SER A 1 22  ? 6.289   -5.187  17.343 1.000 27.261  0 22  SER A OG  1 ? 
ATOM   182  N N   . MET A 1 23  ? 5.639   -5.761  12.993 1.000 27.059  0 23  MET A N   1 ? 
ATOM   183  C CA  . MET A 1 23  ? 4.955   -5.481  11.745 1.000 27.922  0 23  MET A CA  1 ? 
ATOM   184  C C   . MET A 1 23  ? 4.495   -6.780  11.090 1.000 31.067  0 23  MET A C   1 ? 
ATOM   185  O O   . MET A 1 23  ? 3.376   -6.847  10.544 1.000 30.394  0 23  MET A O   1 ? 
ATOM   186  C CB  . MET A 1 23  ? 5.823   -4.659  10.791 1.000 28.818  0 23  MET A CB  1 ? 
ATOM   187  C CG  . MET A 1 23  ? 5.731   -3.168  11.145 1.000 33.192  0 23  MET A CG  1 ? 
ATOM   188  S SD  . MET A 1 23  ? 6.265   -1.933  9.906  1.000 35.715  0 23  MET A SD  1 ? 
ATOM   189  C CE  . MET A 1 23  ? 8.043   -2.117  9.881  1.000 26.285  0 23  MET A CE  1 ? 
ATOM   190  N N   . GLU A 1 24  ? 5.335   -7.814  11.171 1.000 28.640  0 24  GLU A N   1 ? 
ATOM   191  C CA  . GLU A 1 24  ? 4.969   -9.078  10.563 1.000 32.796  0 24  GLU A CA  1 ? 
ATOM   192  C C   . GLU A 1 24  ? 3.778   -9.665  11.314 1.000 32.137  0 24  GLU A C   1 ? 
ATOM   193  O O   . GLU A 1 24  ? 2.980   -10.369 10.702 1.000 31.390  0 24  GLU A O   1 ? 
ATOM   194  C CB  . GLU A 1 24  ? 6.135   -10.063 10.512 1.000 37.523  0 24  GLU A CB  1 ? 
ATOM   195  C CG  . GLU A 1 24  ? 7.386   -9.474  9.883  1.000 45.396  0 24  GLU A CG  1 ? 
ATOM   196  C CD  . GLU A 1 24  ? 8.177   -10.419 9.008  1.000 54.146  0 24  GLU A CD  1 ? 
ATOM   197  O OE1 . GLU A 1 24  ? 8.820   -11.354 9.557  1.000 54.666  0 24  GLU A OE1 1 ? 
ATOM   198  O OE2 . GLU A 1 24  ? 8.140   -10.205 7.774  1.000 73.150  0 24  GLU A OE2 1 ? 
ATOM   199  N N   . ILE A 1 25  ? 3.657   -9.345  12.611 1.000 28.551  0 25  ILE A N   1 ? 
ATOM   200  C CA  . ILE A 1 25  ? 2.641   -9.939  13.459 1.000 31.801  0 25  ILE A CA  1 ? 
ATOM   201  C C   . ILE A 1 25  ? 1.296   -9.248  13.220 1.000 33.260  0 25  ILE A C   1 ? 
ATOM   202  O O   . ILE A 1 25  ? 0.243   -9.820  13.443 1.000 40.110  0 25  ILE A O   1 ? 
ATOM   203  C CB  . ILE A 1 25  ? 3.084   -9.890  14.939 1.000 37.195  0 25  ILE A CB  1 ? 
ATOM   204  C CG1 . ILE A 1 25  ? 4.083   -11.006 15.263 1.000 38.942  0 25  ILE A CG1 1 ? 
ATOM   205  C CG2 . ILE A 1 25  ? 1.896   -9.942  15.880 1.000 36.723  0 25  ILE A CG2 1 ? 
ATOM   206  C CD1 . ILE A 1 25  ? 4.797   -10.803 16.578 1.000 40.150  0 25  ILE A CD1 1 ? 
ATOM   207  N N   . CYS A 1 26  ? 1.328   -8.010  12.756 1.000 32.777  0 26  CYS A N   1 ? 
ATOM   208  C CA  . CYS A 1 26  ? 0.125   -7.287  12.399 1.000 30.144  0 26  CYS A CA  1 ? 
ATOM   209  C C   . CYS A 1 26  ? -0.394  -7.765  11.044 1.000 28.301  0 26  CYS A C   1 ? 
ATOM   210  O O   . CYS A 1 26  ? -1.600  -7.786  10.787 1.000 29.900  0 26  CYS A O   1 ? 
ATOM   211  C CB  . CYS A 1 26  ? 0.445   -5.800  12.367 1.000 29.015  0 26  CYS A CB  1 ? 
ATOM   212  S SG  . CYS A 1 26  ? -0.955  -4.795  11.841 1.000 35.958  0 26  CYS A SG  1 ? 
ATOM   213  N N   . ILE A 1 27  ? 0.517   -8.085  10.129 1.000 28.116  0 27  ILE A N   1 ? 
ATOM   214  C CA  . ILE A 1 27  ? 0.087   -8.565  8.822  1.000 31.782  0 27  ILE A CA  1 ? 
ATOM   215  C C   . ILE A 1 27  ? -0.462  -9.980  8.969  1.000 31.744  0 27  ILE A C   1 ? 
ATOM   216  O O   . ILE A 1 27  ? -1.570  -10.271 8.518  1.000 33.116  0 27  ILE A O   1 ? 
ATOM   217  C CB  . ILE A 1 27  ? 1.223   -8.515  7.780  1.000 33.258  0 27  ILE A CB  1 ? 
ATOM   218  C CG1 . ILE A 1 27  ? 1.660   -7.076  7.488  1.000 38.164  0 27  ILE A CG1 1 ? 
ATOM   219  C CG2 . ILE A 1 27  ? 0.829   -9.241  6.515  1.000 31.266  0 27  ILE A CG2 1 ? 
ATOM   220  C CD1 . ILE A 1 27  ? 0.571   -6.178  6.982  1.000 38.561  0 27  ILE A CD1 1 ? 
ATOM   221  N N   . LYS A 1 28  ? 0.333   -10.841 9.611  1.000 32.526  0 28  LYS A N   1 ? 
ATOM   222  C CA  . LYS A 1 28  ? -0.014  -12.246 9.763  1.000 35.888  0 28  LYS A CA  1 ? 
ATOM   223  C C   . LYS A 1 28  ? -1.278  -12.362 10.616 1.000 33.014  0 28  LYS A C   1 ? 
ATOM   224  O O   . LYS A 1 28  ? -2.149  -13.151 10.300 1.000 32.577  0 28  LYS A O   1 ? 
ATOM   225  C CB  . LYS A 1 28  ? 1.176   -13.015 10.356 1.000 34.911  0 28  LYS A CB  1 ? 
ATOM   226  N N   . GLY A 1 29  ? -1.393  -11.528 11.653 1.000 33.896  0 29  GLY A N   1 ? 
ATOM   227  C CA  . GLY A 1 29  ? -2.389  -11.719 12.695 1.000 34.249  0 29  GLY A CA  1 ? 
ATOM   228  C C   . GLY A 1 29  ? -3.677  -10.912 12.494 1.000 34.955  0 29  GLY A C   1 ? 
ATOM   229  O O   . GLY A 1 29  ? -4.727  -11.349 12.964 1.000 39.182  0 29  GLY A O   1 ? 
ATOM   230  N N   . TYR A 1 30  ? -3.620  -9.756  11.816 1.000 33.721  0 30  TYR A N   1 ? 
ATOM   231  C CA  . TYR A 1 30  ? -4.801  -8.930  11.597 1.000 31.820  0 30  TYR A CA  1 ? 
ATOM   232  C C   . TYR A 1 30  ? -5.202  -8.877  10.129 1.000 34.389  0 30  TYR A C   1 ? 
ATOM   233  O O   . TYR A 1 30  ? -6.299  -9.270  9.744  1.000 41.055  0 30  TYR A O   1 ? 
ATOM   234  C CB  . TYR A 1 30  ? -4.557  -7.495  12.051 1.000 28.336  0 30  TYR A CB  1 ? 
ATOM   235  C CG  . TYR A 1 30  ? -4.674  -7.289  13.528 1.000 29.488  0 30  TYR A CG  1 ? 
ATOM   236  C CD1 . TYR A 1 30  ? -5.843  -7.626  14.194 1.000 34.047  0 30  TYR A CD1 1 ? 
ATOM   237  C CD2 . TYR A 1 30  ? -3.625  -6.774  14.265 1.000 30.434  0 30  TYR A CD2 1 ? 
ATOM   238  C CE1 . TYR A 1 30  ? -5.978  -7.459  15.566 1.000 30.080  0 30  TYR A CE1 1 ? 
ATOM   239  C CE2 . TYR A 1 30  ? -3.746  -6.582  15.632 1.000 29.897  0 30  TYR A CE2 1 ? 
ATOM   240  C CZ  . TYR A 1 30  ? -4.931  -6.911  16.281 1.000 28.575  0 30  TYR A CZ  1 ? 
ATOM   241  O OH  . TYR A 1 30  ? -5.080  -6.724  17.633 1.000 26.386  0 30  TYR A OH  1 ? 
ATOM   242  N N   . TYR A 1 31  ? -4.303  -8.339  9.317  1.000 35.547  0 31  TYR A N   1 ? 
ATOM   243  C CA  . TYR A 1 31  ? -4.595  -8.090  7.923  1.000 33.498  0 31  TYR A CA  1 ? 
ATOM   244  C C   . TYR A 1 31  ? -4.976  -9.373  7.188  1.000 33.086  0 31  TYR A C   1 ? 
ATOM   245  O O   . TYR A 1 31  ? -5.996  -9.414  6.522  1.000 38.873  0 31  TYR A O   1 ? 
ATOM   246  C CB  . TYR A 1 31  ? -3.364  -7.523  7.225  1.000 36.229  0 31  TYR A CB  1 ? 
ATOM   247  C CG  . TYR A 1 31  ? -3.595  -7.278  5.766  1.000 39.273  0 31  TYR A CG  1 ? 
ATOM   248  C CD1 . TYR A 1 31  ? -4.484  -6.300  5.358  1.000 37.066  0 31  TYR A CD1 1 ? 
ATOM   249  C CD2 . TYR A 1 31  ? -2.982  -8.068  4.805  1.000 47.812  0 31  TYR A CD2 1 ? 
ATOM   250  C CE1 . TYR A 1 31  ? -4.717  -6.067  4.014  1.000 46.053  0 31  TYR A CE1 1 ? 
ATOM   251  C CE2 . TYR A 1 31  ? -3.201  -7.850  3.454  1.000 52.380  0 31  TYR A CE2 1 ? 
ATOM   252  C CZ  . TYR A 1 31  ? -4.062  -6.835  3.063  1.000 52.987  0 31  TYR A CZ  1 ? 
ATOM   253  O OH  . TYR A 1 31  ? -4.297  -6.604  1.736  1.000 57.697  0 31  TYR A OH  1 ? 
ATOM   254  N N   . GLU A 1 32  ? -4.141  -10.406 7.261  1.000 31.677  0 32  GLU A N   1 ? 
ATOM   255  C CA  . GLU A 1 32  ? -4.419  -11.621 6.518  1.000 34.264  0 32  GLU A CA  1 ? 
ATOM   256  C C   . GLU A 1 32  ? -5.739  -12.273 6.934  1.000 33.867  0 32  GLU A C   1 ? 
ATOM   257  O O   . GLU A 1 32  ? -6.543  -12.638 6.083  1.000 33.796  0 32  GLU A O   1 ? 
ATOM   258  C CB  . GLU A 1 32  ? -3.230  -12.555 6.597  1.000 38.375  0 32  GLU A CB  1 ? 
ATOM   259  C CG  . GLU A 1 32  ? -2.139  -12.077 5.659  1.000 43.293  0 32  GLU A CG  1 ? 
ATOM   260  C CD  . GLU A 1 32  ? -0.815  -12.800 5.784  1.000 46.998  0 32  GLU A CD  1 ? 
ATOM   261  O OE1 . GLU A 1 32  ? -0.719  -13.731 6.631  1.000 46.376  0 32  GLU A OE1 1 ? 
ATOM   262  O OE2 . GLU A 1 32  ? 0.109   -12.402 5.048  1.000 48.373  0 32  GLU A OE2 1 ? 
ATOM   263  N N   . PRO A 1 33  ? -6.064  -12.428 8.226  1.000 33.467  0 33  PRO A N   1 ? 
ATOM   264  C CA  . PRO A 1 33  ? -7.378  -12.954 8.617  1.000 34.705  0 33  PRO A CA  1 ? 
ATOM   265  C C   . PRO A 1 33  ? -8.579  -12.164 8.098  1.000 38.629  0 33  PRO A C   1 ? 
ATOM   266  O O   . PRO A 1 33  ? -9.565  -12.728 7.623  1.000 37.006  0 33  PRO A O   1 ? 
ATOM   267  C CB  . PRO A 1 33  ? -7.356  -12.875 10.142 1.000 34.367  0 33  PRO A CB  1 ? 
ATOM   268  C CG  . PRO A 1 33  ? -5.887  -12.976 10.486 1.000 36.665  0 33  PRO A CG  1 ? 
ATOM   269  C CD  . PRO A 1 33  ? -5.156  -12.268 9.356  1.000 36.938  0 33  PRO A CD  1 ? 
ATOM   270  N N   . LEU A 1 34  ? -8.478  -10.841 8.169  1.000 39.159  0 34  LEU A N   1 ? 
ATOM   271  C CA  . LEU A 1 34  ? -9.528  -10.000 7.641  1.000 39.713  0 34  LEU A CA  1 ? 
ATOM   272  C C   . LEU A 1 34  ? -9.729  -10.252 6.142  1.000 42.870  0 34  LEU A C   1 ? 
ATOM   273  O O   . LEU A 1 34  ? -10.857 -10.371 5.685  1.000 42.301  0 34  LEU A O   1 ? 
ATOM   274  C CB  . LEU A 1 34  ? -9.161  -8.548  7.949  1.000 35.239  0 34  LEU A CB  1 ? 
ATOM   275  C CG  . LEU A 1 34  ? -9.818  -7.950  9.186  1.000 36.067  0 34  LEU A CG  1 ? 
ATOM   276  C CD1 . LEU A 1 34  ? -10.315 -9.013  10.153 1.000 36.147  0 34  LEU A CD1 1 ? 
ATOM   277  C CD2 . LEU A 1 34  ? -8.855  -7.017  9.905  1.000 36.801  0 34  LEU A CD2 1 ? 
ATOM   278  N N   . ILE A 1 35  ? -8.643  -10.348 5.368  1.000 51.209  0 35  ILE A N   1 ? 
ATOM   279  C CA  . ILE A 1 35  ? -8.760  -10.492 3.918  1.000 53.274  0 35  ILE A CA  1 ? 
ATOM   280  C C   . ILE A 1 35  ? -9.248  -11.887 3.527  1.000 49.947  0 35  ILE A C   1 ? 
ATOM   281  O O   . ILE A 1 35  ? -9.909  -12.018 2.507  1.000 47.067  0 35  ILE A O   1 ? 
ATOM   282  C CB  . ILE A 1 35  ? -7.431  -10.138 3.223  1.000 56.925  0 35  ILE A CB  1 ? 
ATOM   283  C CG1 . ILE A 1 35  ? -7.095  -8.651  3.389  1.000 53.178  0 35  ILE A CG1 1 ? 
ATOM   284  C CG2 . ILE A 1 35  ? -7.464  -10.550 1.756  1.000 63.001  0 35  ILE A CG2 1 ? 
ATOM   285  C CD1 . ILE A 1 35  ? -8.031  -7.704  2.666  1.000 48.396  0 35  ILE A CD1 1 ? 
ATOM   286  N N   . GLN A 1 36  ? -8.916  -12.917 4.320  1.000 58.068  0 36  GLN A N   1 ? 
ATOM   287  C CA  . GLN A 1 36  ? -9.327  -14.280 4.018  1.000 51.589  0 36  GLN A CA  1 ? 
ATOM   288  C C   . GLN A 1 36  ? -10.763 -14.489 4.487  1.000 53.969  0 36  GLN A C   1 ? 
ATOM   289  O O   . GLN A 1 36  ? -11.546 -15.088 3.753  1.000 53.418  0 36  GLN A O   1 ? 
ATOM   290  C CB  . GLN A 1 36  ? -8.382  -15.314 4.640  1.000 50.055  0 36  GLN A CB  1 ? 
ATOM   291  N N   . SER A 1 37  ? -11.115 -13.986 5.689  1.000 56.404  0 37  SER A N   1 ? 
ATOM   292  C CA  . SER A 1 37  ? -12.391 -14.319 6.317  1.000 53.173  0 37  SER A CA  1 ? 
ATOM   293  C C   . SER A 1 37  ? -13.529 -13.691 5.518  1.000 62.305  0 37  SER A C   1 ? 
ATOM   294  O O   . SER A 1 37  ? -14.626 -14.252 5.424  1.000 60.014  0 37  SER A O   1 ? 
ATOM   295  C CB  . SER A 1 37  ? -12.454 -13.888 7.762  1.000 47.200  0 37  SER A CB  1 ? 
ATOM   296  N N   . GLY A 1 38  ? -13.243 -12.514 4.940  1.000 64.835  0 38  GLY A N   1 ? 
ATOM   297  C CA  . GLY A 1 38  ? -14.213 -11.791 4.132  1.000 62.983  0 38  GLY A CA  1 ? 
ATOM   298  C C   . GLY A 1 38  ? -15.539 -11.555 4.857  1.000 56.745  0 38  GLY A C   1 ? 
ATOM   299  O O   . GLY A 1 38  ? -16.593 -11.866 4.308  1.000 49.563  0 38  GLY A O   1 ? 
ATOM   300  N N   . HIS A 1 39  ? -15.457 -11.010 6.080  1.000 53.888  0 39  HIS A N   1 ? 
ATOM   301  C CA  . HIS A 1 39  ? -16.631 -10.642 6.855  1.000 50.840  0 39  HIS A CA  1 ? 
ATOM   302  C C   . HIS A 1 39  ? -17.371 -9.498  6.165  1.000 47.506  0 39  HIS A C   1 ? 
ATOM   303  O O   . HIS A 1 39  ? -16.751 -8.593  5.602  1.000 46.806  0 39  HIS A O   1 ? 
ATOM   304  C CB  . HIS A 1 39  ? -16.270 -10.238 8.289  1.000 52.289  0 39  HIS A CB  1 ? 
ATOM   305  C CG  . HIS A 1 39  ? -15.595 -11.328 9.035  1.000 62.421  0 39  HIS A CG  1 ? 
ATOM   306  N ND1 . HIS A 1 39  ? -16.169 -12.573 9.193  1.000 65.266  0 39  HIS A ND1 1 ? 
ATOM   307  C CD2 . HIS A 1 39  ? -14.394 -11.384 9.632  1.000 69.020  0 39  HIS A CD2 1 ? 
ATOM   308  C CE1 . HIS A 1 39  ? -15.343 -13.342 9.890  1.000 70.942  0 39  HIS A CE1 1 ? 
ATOM   309  N NE2 . HIS A 1 39  ? -14.257 -12.645 10.164 1.000 73.178  0 39  HIS A NE2 1 ? 
ATOM   310  N N   . SER A 1 40  ? -18.706 -9.563  6.259  1.000 41.407  0 40  SER A N   1 ? 
ATOM   311  C CA  . SER A 1 40  ? -19.632 -8.543  5.802  1.000 42.600  0 40  SER A CA  1 ? 
ATOM   312  C C   . SER A 1 40  ? -19.335 -7.194  6.463  1.000 44.709  0 40  SER A C   1 ? 
ATOM   313  O O   . SER A 1 40  ? -19.490 -6.139  5.852  1.000 41.099  0 40  SER A O   1 ? 
ATOM   314  C CB  . SER A 1 40  ? -21.051 -8.993  6.110  1.000 44.295  0 40  SER A CB  1 ? 
ATOM   315  O OG  . SER A 1 40  ? -22.011 -7.953  5.924  1.000 38.612  0 40  SER A OG  1 ? 
ATOM   316  N N   . VAL A 1 41  ? -18.926 -7.232  7.731  1.000 46.150  0 41  VAL A N   1 ? 
ATOM   317  C CA  . VAL A 1 41  ? -18.702 -6.016  8.499  1.000 48.108  0 41  VAL A CA  1 ? 
ATOM   318  C C   . VAL A 1 41  ? -17.253 -5.525  8.363  1.000 47.253  0 41  VAL A C   1 ? 
ATOM   319  O O   . VAL A 1 41  ? -16.964 -4.419  8.813  1.000 47.189  0 41  VAL A O   1 ? 
ATOM   320  C CB  . VAL A 1 41  ? -19.153 -6.219  9.963  1.000 47.974  0 41  VAL A CB  1 ? 
ATOM   321  C CG1 . VAL A 1 41  ? -18.295 -7.234  10.712 1.000 49.242  0 41  VAL A CG1 1 ? 
ATOM   322  C CG2 . VAL A 1 41  ? -19.254 -4.899  10.716 1.000 47.621  0 41  VAL A CG2 1 ? 
ATOM   323  N N   . ALA A 1 42  ? -16.389 -6.301  7.678  1.000 45.878  0 42  ALA A N   1 ? 
ATOM   324  C CA  . ALA A 1 42  ? -15.030 -5.901  7.339  1.000 43.294  0 42  ALA A CA  1 ? 
ATOM   325  C C   . ALA A 1 42  ? -14.732 -6.166  5.856  1.000 46.673  0 42  ALA A C   1 ? 
ATOM   326  O O   . ALA A 1 42  ? -13.913 -7.027  5.496  1.000 40.270  0 42  ALA A O   1 ? 
ATOM   327  C CB  . ALA A 1 42  ? -14.061 -6.645  8.214  1.000 46.811  0 42  ALA A CB  1 ? 
ATOM   328  N N   . PRO A 1 43  ? -15.361 -5.415  4.923  1.000 44.367  0 43  PRO A N   1 ? 
ATOM   329  C CA  . PRO A 1 43  ? -15.106 -5.621  3.502  1.000 40.625  0 43  PRO A CA  1 ? 
ATOM   330  C C   . PRO A 1 43  ? -13.677 -5.220  3.128  1.000 40.529  0 43  PRO A C   1 ? 
ATOM   331  O O   . PRO A 1 43  ? -13.103 -4.289  3.705  1.000 35.881  0 43  PRO A O   1 ? 
ATOM   332  C CB  . PRO A 1 43  ? -16.164 -4.761  2.822  1.000 37.175  0 43  PRO A CB  1 ? 
ATOM   333  C CG  . PRO A 1 43  ? -16.460 -3.685  3.820  1.000 40.235  0 43  PRO A CG  1 ? 
ATOM   334  C CD  . PRO A 1 43  ? -16.300 -4.318  5.185  1.000 40.776  0 43  PRO A CD  1 ? 
ATOM   335  N N   . ALA A 1 44  ? -13.162 -5.962  2.135  1.000 37.665  0 44  ALA A N   1 ? 
ATOM   336  C CA  . ALA A 1 44  ? -11.814 -5.874  1.607  1.000 33.606  0 44  ALA A CA  1 ? 
ATOM   337  C C   . ALA A 1 44  ? -11.412 -4.440  1.338  1.000 31.562  0 44  ALA A C   1 ? 
ATOM   338  O O   . ALA A 1 44  ? -10.286 -4.070  1.606  1.000 31.294  0 44  ALA A O   1 ? 
ATOM   339  C CB  . ALA A 1 44  ? -11.706 -6.666  0.339  1.000 31.742  0 44  ALA A CB  1 ? 
ATOM   340  N N   . ASP A 1 45  ? -12.313 -3.651  0.777  1.000 35.868  0 45  ASP A N   1 ? 
ATOM   341  C CA  . ASP A 1 45  ? -11.942 -2.303  0.376  1.000 43.572  0 45  ASP A CA  1 ? 
ATOM   342  C C   . ASP A 1 45  ? -11.646 -1.480  1.620  1.000 40.790  0 45  ASP A C   1 ? 
ATOM   343  O O   . ASP A 1 45  ? -10.628 -0.783  1.670  1.000 38.549  0 45  ASP A O   1 ? 
ATOM   344  C CB  . ASP A 1 45  ? -12.998 -1.681  -0.549 1.000 51.332  0 45  ASP A CB  1 ? 
ATOM   345  C CG  . ASP A 1 45  ? -12.856 -2.081  -2.019 1.000 54.485  0 45  ASP A CG  1 ? 
ATOM   346  O OD1 . ASP A 1 45  ? -11.754 -2.558  -2.418 1.000 51.836  0 45  ASP A OD1 1 ? 
ATOM   347  O OD2 . ASP A 1 45  ? -13.854 -1.927  -2.768 1.000 66.444  0 45  ASP A OD2 1 ? 
ATOM   348  N N   . LYS A 1 46  ? -12.531 -1.612  2.619  1.000 40.438  0 46  LYS A N   1 ? 
ATOM   349  C CA  . LYS A 1 46  ? -12.326 -0.980  3.902  1.000 43.132  0 46  LYS A CA  1 ? 
ATOM   350  C C   . LYS A 1 46  ? -11.007 -1.463  4.507  1.000 35.331  0 46  LYS A C   1 ? 
ATOM   351  O O   . LYS A 1 46  ? -10.149 -0.651  4.825  1.000 36.821  0 46  LYS A O   1 ? 
ATOM   352  C CB  . LYS A 1 46  ? -13.559 -1.170  4.788  1.000 48.396  0 46  LYS A CB  1 ? 
ATOM   353  C CG  . LYS A 1 46  ? -14.526 0.010   4.746  1.000 62.955  0 46  LYS A CG  1 ? 
ATOM   354  C CD  . LYS A 1 46  ? -15.259 0.197   3.433  1.000 75.980  0 46  LYS A CD  1 ? 
ATOM   355  C CE  . LYS A 1 46  ? -15.026 1.559   2.812  1.000 87.651  0 46  LYS A CE  1 ? 
ATOM   356  N NZ  . LYS A 1 46  ? -13.638 1.683   2.289  1.000 100.341 0 46  LYS A NZ  1 ? 
ATOM   357  N N   . VAL A 1 47  ? -10.827 -2.774  4.637  1.000 31.352  0 47  VAL A N   1 ? 
ATOM   358  C CA  . VAL A 1 47  ? -9.591  -3.306  5.189  1.000 28.935  0 47  VAL A CA  1 ? 
ATOM   359  C C   . VAL A 1 47  ? -8.379  -2.787  4.418  1.000 28.598  0 47  VAL A C   1 ? 
ATOM   360  O O   . VAL A 1 47  ? -7.381  -2.407  5.009  1.000 25.710  0 47  VAL A O   1 ? 
ATOM   361  C CB  . VAL A 1 47  ? -9.583  -4.839  5.188  1.000 27.828  0 47  VAL A CB  1 ? 
ATOM   362  C CG1 . VAL A 1 47  ? -8.280  -5.341  5.768  1.000 29.990  0 47  VAL A CG1 1 ? 
ATOM   363  C CG2 . VAL A 1 47  ? -10.750 -5.426  5.970  1.000 27.774  0 47  VAL A CG2 1 ? 
ATOM   364  N N   . ASN A 1 48  ? -8.432  -2.819  3.088  1.000 30.373  0 48  ASN A N   1 ? 
ATOM   365  C CA  . ASN A 1 48  ? -7.252  -2.494  2.323  1.000 30.051  0 48  ASN A CA  1 ? 
ATOM   366  C C   . ASN A 1 48  ? -6.949  -1.016  2.454  1.000 29.009  0 48  ASN A C   1 ? 
ATOM   367  O O   . ASN A 1 48  ? -5.777  -0.666  2.460  1.000 31.424  0 48  ASN A O   1 ? 
ATOM   368  C CB  . ASN A 1 48  ? -7.358  -2.894  0.860  1.000 32.823  0 48  ASN A CB  1 ? 
ATOM   369  C CG  . ASN A 1 48  ? -6.934  -4.329  0.665  1.000 32.509  0 48  ASN A CG  1 ? 
ATOM   370  O OD1 . ASN A 1 48  ? -5.819  -4.687  1.013  1.000 38.368  0 48  ASN A OD1 1 ? 
ATOM   371  N ND2 . ASN A 1 48  ? -7.801  -5.155  0.121  1.000 35.802  0 48  ASN A ND2 1 ? 
ATOM   372  N N   . ALA A 1 49  ? -7.974  -0.160  2.536  1.000 25.937  0 49  ALA A N   1 ? 
ATOM   373  C CA  . ALA A 1 49  ? -7.674  1.262   2.661  1.000 26.585  0 49  ALA A CA  1 ? 
ATOM   374  C C   . ALA A 1 49  ? -7.006  1.513   4.005  1.000 26.709  0 49  ALA A C   1 ? 
ATOM   375  O O   . ALA A 1 49  ? -6.112  2.357   4.104  1.000 28.965  0 49  ALA A O   1 ? 
ATOM   376  C CB  . ALA A 1 49  ? -8.891  2.126   2.474  1.000 28.935  0 49  ALA A CB  1 ? 
ATOM   377  N N   . VAL A 1 50  ? -7.396  0.705   5.000  1.000 24.980  0 50  VAL A N   1 ? 
ATOM   378  C CA  . VAL A 1 50  ? -6.806  0.789   6.324  1.000 25.062  0 50  VAL A CA  1 ? 
ATOM   379  C C   . VAL A 1 50  ? -5.319  0.416   6.316  1.000 24.877  0 50  VAL A C   1 ? 
ATOM   380  O O   . VAL A 1 50  ? -4.501  1.088   6.951  1.000 22.952  0 50  VAL A O   1 ? 
ATOM   381  C CB  . VAL A 1 50  ? -7.587  -0.065  7.337  1.000 24.139  0 50  VAL A CB  1 ? 
ATOM   382  C CG1 . VAL A 1 50  ? -6.792  -0.302  8.604  1.000 24.607  0 50  VAL A CG1 1 ? 
ATOM   383  C CG2 . VAL A 1 50  ? -8.920  0.574   7.684  1.000 23.447  0 50  VAL A CG2 1 ? 
ATOM   384  N N   . PHE A 1 51  ? -4.966  -0.669  5.619  1.000 27.099  0 51  PHE A N   1 ? 
ATOM   385  C CA  . PHE A 1 51  ? -3.619  -1.200  5.685  1.000 27.408  0 51  PHE A CA  1 ? 
ATOM   386  C C   . PHE A 1 51  ? -2.747  -0.698  4.537  1.000 28.843  0 51  PHE A C   1 ? 
ATOM   387  O O   . PHE A 1 51  ? -1.575  -1.063  4.428  1.000 29.460  0 51  PHE A O   1 ? 
ATOM   388  C CB  . PHE A 1 51  ? -3.657  -2.724  5.710  1.000 29.269  0 51  PHE A CB  1 ? 
ATOM   389  C CG  . PHE A 1 51  ? -4.087  -3.302  7.033  1.000 29.930  0 51  PHE A CG  1 ? 
ATOM   390  C CD1 . PHE A 1 51  ? -5.420  -3.325  7.402  1.000 31.165  0 51  PHE A CD1 1 ? 
ATOM   391  C CD2 . PHE A 1 51  ? -3.160  -3.797  7.922  1.000 32.103  0 51  PHE A CD2 1 ? 
ATOM   392  C CE1 . PHE A 1 51  ? -5.824  -3.854  8.616  1.000 32.119  0 51  PHE A CE1 1 ? 
ATOM   393  C CE2 . PHE A 1 51  ? -3.562  -4.336  9.141  1.000 33.875  0 51  PHE A CE2 1 ? 
ATOM   394  C CZ  . PHE A 1 51  ? -4.895  -4.392  9.474  1.000 34.153  0 51  PHE A CZ  1 ? 
ATOM   395  N N   . LEU A 1 52  ? -3.288  0.158   3.682  1.000 28.618  0 52  LEU A N   1 ? 
ATOM   396  C CA  . LEU A 1 52  ? -2.589  0.486   2.457  1.000 29.790  0 52  LEU A CA  1 ? 
ATOM   397  C C   . LEU A 1 52  ? -1.200  1.056   2.774  1.000 28.953  0 52  LEU A C   1 ? 
ATOM   398  O O   . LEU A 1 52  ? -1.103  1.939   3.603  1.000 30.045  0 52  LEU A O   1 ? 
ATOM   399  C CB  . LEU A 1 52  ? -3.442  1.484   1.676  1.000 32.540  0 52  LEU A CB  1 ? 
ATOM   400  C CG  . LEU A 1 52  ? -2.970  1.724   0.244  1.000 37.775  0 52  LEU A CG  1 ? 
ATOM   401  C CD1 . LEU A 1 52  ? -3.209  0.472   -0.609 1.000 38.410  0 52  LEU A CD1 1 ? 
ATOM   402  C CD2 . LEU A 1 52  ? -3.646  2.960   -0.347 1.000 36.363  0 52  LEU A CD2 1 ? 
ATOM   403  N N   . HIS A 1 53  ? -0.155  0.538   2.101  1.000 28.741  0 53  HIS A N   1 ? 
ATOM   404  C CA  . HIS A 1 53  ? 1.236   0.979   2.180  1.000 28.599  0 53  HIS A CA  1 ? 
ATOM   405  C C   . HIS A 1 53  ? 1.941   0.452   3.425  1.000 27.802  0 53  HIS A C   1 ? 
ATOM   406  O O   . HIS A 1 53  ? 2.904   1.042   3.882  1.000 39.689  0 53  HIS A O   1 ? 
ATOM   407  C CB  . HIS A 1 53  ? 1.383   2.505   2.148  1.000 32.316  0 53  HIS A CB  1 ? 
ATOM   408  C CG  . HIS A 1 53  ? 0.716   3.165   0.997  1.000 36.395  0 53  HIS A CG  1 ? 
ATOM   409  N ND1 . HIS A 1 53  ? 1.023   2.837   -0.307 1.000 35.740  0 53  HIS A ND1 1 ? 
ATOM   410  C CD2 . HIS A 1 53  ? -0.246  4.107   0.963  1.000 37.907  0 53  HIS A CD2 1 ? 
ATOM   411  C CE1 . HIS A 1 53  ? 0.249   3.552   -1.109 1.000 37.630  0 53  HIS A CE1 1 ? 
ATOM   412  N NE2 . HIS A 1 53  ? -0.519  4.329   -0.360 1.000 43.805  0 53  HIS A NE2 1 ? 
ATOM   413  N N   . PHE A 1 54  ? 1.461   -0.636  4.014  1.000 28.247  0 54  PHE A N   1 ? 
ATOM   414  C CA  . PHE A 1 54  ? 2.010   -1.114  5.263  1.000 25.856  0 54  PHE A CA  1 ? 
ATOM   415  C C   . PHE A 1 54  ? 2.982   -2.239  4.953  1.000 26.729  0 54  PHE A C   1 ? 
ATOM   416  O O   . PHE A 1 54  ? 4.129   -2.203  5.412  1.000 27.260  0 54  PHE A O   1 ? 
ATOM   417  C CB  . PHE A 1 54  ? 0.883   -1.495  6.212  1.000 27.115  0 54  PHE A CB  1 ? 
ATOM   418  C CG  . PHE A 1 54  ? 1.309   -1.790  7.624  1.000 32.649  0 54  PHE A CG  1 ? 
ATOM   419  C CD1 . PHE A 1 54  ? 1.495   -0.768  8.535  1.000 33.903  0 54  PHE A CD1 1 ? 
ATOM   420  C CD2 . PHE A 1 54  ? 1.487   -3.099  8.059  1.000 38.212  0 54  PHE A CD2 1 ? 
ATOM   421  C CE1 . PHE A 1 54  ? 1.883   -1.038  9.841  1.000 37.299  0 54  PHE A CE1 1 ? 
ATOM   422  C CE2 . PHE A 1 54  ? 1.863   -3.374  9.368  1.000 41.944  0 54  PHE A CE2 1 ? 
ATOM   423  C CZ  . PHE A 1 54  ? 2.055   -2.337  10.261 1.000 38.259  0 54  PHE A CZ  1 ? 
ATOM   424  N N   . GLN A 1 55  ? 2.546   -3.222  4.151  1.000 28.719  0 55  GLN A N   1 ? 
ATOM   425  C CA  . GLN A 1 55  ? 3.470   -4.229  3.622  1.000 30.292  0 55  GLN A CA  1 ? 
ATOM   426  C C   . GLN A 1 55  ? 4.685   -3.552  2.971  1.000 23.465  0 55  GLN A C   1 ? 
ATOM   427  O O   . GLN A 1 55  ? 5.796   -4.055  3.043  1.000 20.405  0 55  GLN A O   1 ? 
ATOM   428  C CB  . GLN A 1 55  ? 2.761   -5.135  2.613  1.000 34.727  0 55  GLN A CB  1 ? 
ATOM   429  C CG  . GLN A 1 55  ? 1.759   -6.075  3.262  1.000 47.237  0 55  GLN A CG  1 ? 
ATOM   430  C CD  . GLN A 1 55  ? 0.604   -6.459  2.365  1.000 53.810  0 55  GLN A CD  1 ? 
ATOM   431  O OE1 . GLN A 1 55  ? -0.539  -6.097  2.628  1.000 61.082  0 55  GLN A OE1 1 ? 
ATOM   432  N NE2 . GLN A 1 55  ? 0.879   -7.207  1.307  1.000 54.621  0 55  GLN A NE2 1 ? 
ATOM   433  N N   . SER A 1 56  ? 4.476   -2.394  2.344  1.000 21.409  0 56  SER A N   1 ? 
ATOM   434  C CA  . SER A 1 56  ? 5.553   -1.696  1.655  1.000 24.003  0 56  SER A CA  1 ? 
ATOM   435  C C   . SER A 1 56  ? 6.607   -1.240  2.636  1.000 22.161  0 56  SER A C   1 ? 
ATOM   436  O O   . SER A 1 56  ? 7.792   -1.317  2.359  1.000 24.439  0 56  SER A O   1 ? 
ATOM   437  C CB  . SER A 1 56  ? 5.058   -0.513  0.869  1.000 26.001  0 56  SER A CB  1 ? 
ATOM   438  O OG  . SER A 1 56  ? 4.388   -0.938  -0.305 1.000 25.566  0 56  SER A OG  1 ? 
ATOM   439  N N   . VAL A 1 57  ? 6.160   -0.791  3.803  1.000 25.751  0 57  VAL A N   1 ? 
ATOM   440  C CA  . VAL A 1 57  ? 7.066   -0.371  4.858  1.000 24.413  0 57  VAL A CA  1 ? 
ATOM   441  C C   . VAL A 1 57  ? 7.733   -1.585  5.477  1.000 25.314  0 57  VAL A C   1 ? 
ATOM   442  O O   . VAL A 1 57  ? 8.951   -1.612  5.582  1.000 25.065  0 57  VAL A O   1 ? 
ATOM   443  C CB  . VAL A 1 57  ? 6.344   0.497   5.886  1.000 23.408  0 57  VAL A CB  1 ? 
ATOM   444  C CG1 . VAL A 1 57  ? 7.215   0.796   7.074  1.000 26.491  0 57  VAL A CG1 1 ? 
ATOM   445  C CG2 . VAL A 1 57  ? 5.920   1.784   5.236  1.000 23.548  0 57  VAL A CG2 1 ? 
ATOM   446  N N   . LEU A 1 58  ? 6.954   -2.618  5.809  1.000 31.459  0 58  LEU A N   1 ? 
ATOM   447  C CA  . LEU A 1 58  ? 7.553   -3.868  6.263  1.000 31.917  0 58  LEU A CA  1 ? 
ATOM   448  C C   . LEU A 1 58  ? 8.662   -4.291  5.295  1.000 31.993  0 58  LEU A C   1 ? 
ATOM   449  O O   . LEU A 1 58  ? 9.772   -4.586  5.718  1.000 38.182  0 58  LEU A O   1 ? 
ATOM   450  C CB  . LEU A 1 58  ? 6.475   -4.945  6.404  1.000 34.974  0 58  LEU A CB  1 ? 
ATOM   451  C CG  . LEU A 1 58  ? 6.995   -6.341  6.756  1.000 39.915  0 58  LEU A CG  1 ? 
ATOM   452  C CD1 . LEU A 1 58  ? 7.924   -6.294  7.960  1.000 46.434  0 58  LEU A CD1 1 ? 
ATOM   453  C CD2 . LEU A 1 58  ? 5.863   -7.291  7.051  1.000 41.571  0 58  LEU A CD2 1 ? 
ATOM   454  N N   . SER A 1 59  ? 8.413   -4.259  3.987  1.000 30.640  0 59  SER A N   1 ? 
ATOM   455  C CA  . SER A 1 59  ? 9.395   -4.802  3.053  1.000 32.018  0 59  SER A CA  1 ? 
ATOM   456  C C   . SER A 1 59  ? 10.752  -4.118  3.195  1.000 31.590  0 59  SER A C   1 ? 
ATOM   457  O O   . SER A 1 59  ? 11.771  -4.787  3.341  1.000 32.767  0 59  SER A O   1 ? 
ATOM   458  C CB  . SER A 1 59  ? 8.930   -4.735  1.638  1.000 32.263  0 59  SER A CB  1 ? 
ATOM   459  O OG  . SER A 1 59  ? 7.683   -5.396  1.487  1.000 41.148  0 59  SER A OG  1 ? 
ATOM   460  N N   . ILE A 1 60  ? 10.783  -2.783  3.153  1.000 29.110  0 60  ILE A N   1 ? 
ATOM   461  C CA  . ILE A 1 60  ? 12.060  -2.094  3.058  1.000 25.374  0 60  ILE A CA  1 ? 
ATOM   462  C C   . ILE A 1 60  ? 12.771  -2.129  4.404  1.000 28.361  0 60  ILE A C   1 ? 
ATOM   463  O O   . ILE A 1 60  ? 14.004  -2.115  4.443  1.000 27.146  0 60  ILE A O   1 ? 
ATOM   464  C CB  . ILE A 1 60  ? 11.902  -0.656  2.523  1.000 25.714  0 60  ILE A CB  1 ? 
ATOM   465  C CG1 . ILE A 1 60  ? 11.125  0.281   3.456  1.000 27.541  0 60  ILE A CG1 1 ? 
ATOM   466  C CG2 . ILE A 1 60  ? 11.277  -0.682  1.142  1.000 26.354  0 60  ILE A CG2 1 ? 
ATOM   467  C CD1 . ILE A 1 60  ? 11.277  1.745   3.081  1.000 27.162  0 60  ILE A CD1 1 ? 
ATOM   468  N N   . ASN A 1 61  ? 11.990  -2.133  5.499  1.000 30.426  0 61  ASN A N   1 ? 
ATOM   469  C CA  . ASN A 1 61  ? 12.515  -2.304  6.849  1.000 28.039  0 61  ASN A CA  1 ? 
ATOM   470  C C   . ASN A 1 61  ? 13.052  -3.722  7.042  1.000 25.383  0 61  ASN A C   1 ? 
ATOM   471  O O   . ASN A 1 61  ? 14.112  -3.904  7.624  1.000 23.513  0 61  ASN A O   1 ? 
ATOM   472  C CB  . ASN A 1 61  ? 11.464  -1.935  7.899  1.000 28.569  0 61  ASN A CB  1 ? 
ATOM   473  C CG  . ASN A 1 61  ? 11.382  -0.436  8.070  1.000 32.489  0 61  ASN A CG  1 ? 
ATOM   474  O OD1 . ASN A 1 61  ? 12.155  0.165   8.810  1.000 38.091  0 61  ASN A OD1 1 ? 
ATOM   475  N ND2 . ASN A 1 61  ? 10.479  0.201   7.362  1.000 36.889  0 61  ASN A ND2 1 ? 
ATOM   476  N N   . LYS A 1 62  ? 12.369  -4.737  6.517  1.000 26.892  0 62  LYS A N   1 ? 
ATOM   477  C CA  . LYS A 1 62  ? 12.905  -6.096  6.615  1.000 31.835  0 62  LYS A CA  1 ? 
ATOM   478  C C   . LYS A 1 62  ? 14.267  -6.214  5.906  1.000 30.005  0 62  LYS A C   1 ? 
ATOM   479  O O   . LYS A 1 62  ? 15.151  -6.899  6.406  1.000 30.991  0 62  LYS A O   1 ? 
ATOM   480  C CB  . LYS A 1 62  ? 11.893  -7.134  6.115  1.000 34.132  0 62  LYS A CB  1 ? 
ATOM   481  C CG  . LYS A 1 62  ? 11.993  -8.489  6.794  1.000 42.185  0 62  LYS A CG  1 ? 
ATOM   482  C CD  . LYS A 1 62  ? 10.936  -9.457  6.376  1.000 45.619  0 62  LYS A CD  1 ? 
ATOM   483  C CE  . LYS A 1 62  ? 11.198  -10.044 5.011  1.000 51.670  0 62  LYS A CE  1 ? 
ATOM   484  N NZ  . LYS A 1 62  ? 10.484  -11.336 4.856  1.000 60.639  0 62  LYS A NZ  1 ? 
ATOM   485  N N   . GLU A 1 63  ? 14.443  -5.554  4.749  1.000 26.239  0 63  GLU A N   1 ? 
ATOM   486  C CA  . GLU A 1 63  ? 15.724  -5.559  4.052  1.000 29.795  0 63  GLU A CA  1 ? 
ATOM   487  C C   . GLU A 1 63  ? 16.789  -4.803  4.861  1.000 28.267  0 63  GLU A C   1 ? 
ATOM   488  O O   . GLU A 1 63  ? 17.967  -5.187  4.880  1.000 27.761  0 63  GLU A O   1 ? 
ATOM   489  C CB  . GLU A 1 63  ? 15.601  -4.983  2.627  1.000 27.059  0 63  GLU A CB  1 ? 
ATOM   490  N N   . LEU A 1 64  ? 16.385  -3.714  5.518  1.000 26.874  0 64  LEU A N   1 ? 
ATOM   491  C CA  . LEU A 1 64  ? 17.315  -2.966  6.354  1.000 31.811  0 64  LEU A CA  1 ? 
ATOM   492  C C   . LEU A 1 64  ? 17.817  -3.849  7.500  1.000 30.937  0 64  LEU A C   1 ? 
ATOM   493  O O   . LEU A 1 64  ? 19.008  -3.850  7.812  1.000 28.395  0 64  LEU A O   1 ? 
ATOM   494  C CB  . LEU A 1 64  ? 16.632  -1.708  6.892  1.000 28.443  0 64  LEU A CB  1 ? 
ATOM   495  C CG  . LEU A 1 64  ? 17.412  -0.941  7.950  1.000 29.706  0 64  LEU A CG  1 ? 
ATOM   496  C CD1 . LEU A 1 64  ? 18.682  -0.341  7.391  1.000 29.643  0 64  LEU A CD1 1 ? 
ATOM   497  C CD2 . LEU A 1 64  ? 16.560  0.154   8.567  1.000 33.696  0 64  LEU A CD2 1 ? 
ATOM   498  N N   . LEU A 1 65  ? 16.890  -4.582  8.125  1.000 32.748  0 65  LEU A N   1 ? 
ATOM   499  C CA  . LEU A 1 65  ? 17.222  -5.498  9.210  1.000 35.694  0 65  LEU A CA  1 ? 
ATOM   500  C C   . LEU A 1 65  ? 18.142  -6.609  8.709  1.000 30.570  0 65  LEU A C   1 ? 
ATOM   501  O O   . LEU A 1 65  ? 19.098  -6.976  9.372  1.000 28.238  0 65  LEU A O   1 ? 
ATOM   502  C CB  . LEU A 1 65  ? 15.923  -6.067  9.798  1.000 38.845  0 65  LEU A CB  1 ? 
ATOM   503  C CG  . LEU A 1 65  ? 16.079  -7.060  10.948 1.000 44.930  0 65  LEU A CG  1 ? 
ATOM   504  C CD1 . LEU A 1 65  ? 16.609  -6.379  12.200 1.000 45.245  0 65  LEU A CD1 1 ? 
ATOM   505  C CD2 . LEU A 1 65  ? 14.760  -7.752  11.256 1.000 47.489  0 65  LEU A CD2 1 ? 
ATOM   506  N N   . LYS A 1 66  ? 17.840  -7.136  7.529  1.000 33.458  0 66  LYS A N   1 ? 
ATOM   507  C CA  . LYS A 1 66  ? 18.656  -8.164  6.907  1.000 38.627  0 66  LYS A CA  1 ? 
ATOM   508  C C   . LYS A 1 66  ? 20.118  -7.699  6.937  1.000 37.519  0 66  LYS A C   1 ? 
ATOM   509  O O   . LYS A 1 66  ? 21.006  -8.343  7.497  1.000 35.033  0 66  LYS A O   1 ? 
ATOM   510  C CB  . LYS A 1 66  ? 18.144  -8.419  5.476  1.000 46.392  0 66  LYS A CB  1 ? 
ATOM   511  C CG  . LYS A 1 66  ? 18.009  -9.859  4.984  1.000 49.938  0 66  LYS A CG  1 ? 
ATOM   512  C CD  . LYS A 1 66  ? 19.289  -10.508 4.498  1.000 57.168  0 66  LYS A CD  1 ? 
ATOM   513  C CE  . LYS A 1 66  ? 19.056  -11.593 3.464  1.000 57.013  0 66  LYS A CE  1 ? 
ATOM   514  N NZ  . LYS A 1 66  ? 18.658  -11.037 2.145  1.000 58.213  0 66  LYS A NZ  1 ? 
ATOM   515  N N   . ASN A 1 67  ? 20.363  -6.528  6.355  1.000 39.212  0 67  ASN A N   1 ? 
ATOM   516  C CA  . ASN A 1 67  ? 21.718  -6.049  6.151  1.000 37.134  0 67  ASN A CA  1 ? 
ATOM   517  C C   . ASN A 1 67  ? 22.349  -5.758  7.516  1.000 31.768  0 67  ASN A C   1 ? 
ATOM   518  O O   . ASN A 1 67  ? 23.521  -6.013  7.757  1.000 28.699  0 67  ASN A O   1 ? 
ATOM   519  C CB  . ASN A 1 67  ? 21.704  -4.887  5.146  1.000 39.899  0 67  ASN A CB  1 ? 
ATOM   520  C CG  . ASN A 1 67  ? 21.097  -5.259  3.797  1.000 42.162  0 67  ASN A CG  1 ? 
ATOM   521  O OD1 . ASN A 1 67  ? 21.087  -6.422  3.383  1.000 46.438  0 67  ASN A OD1 1 ? 
ATOM   522  N ND2 . ASN A 1 67  ? 20.579  -4.275  3.078  1.000 44.753  0 67  ASN A ND2 1 ? 
ATOM   523  N N   . MET A 1 68  ? 21.556  -5.230  8.435  1.000 35.955  0 68  MET A N   1 ? 
ATOM   524  C CA  . MET A 1 68  ? 22.044  -4.952  9.776  1.000 36.914  0 68  MET A CA  1 ? 
ATOM   525  C C   . MET A 1 68  ? 22.440  -6.268  10.436 1.000 33.502  0 68  MET A C   1 ? 
ATOM   526  O O   . MET A 1 68  ? 23.459  -6.341  11.137 1.000 28.048  0 68  MET A O   1 ? 
ATOM   527  C CB  . MET A 1 68  ? 20.964  -4.279  10.624 1.000 37.036  0 68  MET A CB  1 ? 
ATOM   528  C CG  . MET A 1 68  ? 20.923  -2.797  10.466 1.000 37.425  0 68  MET A CG  1 ? 
ATOM   529  S SD  . MET A 1 68  ? 19.636  -2.054  11.476 1.000 48.033  0 68  MET A SD  1 ? 
ATOM   530  C CE  . MET A 1 68  ? 20.580  -1.641  12.933 1.000 59.209  0 68  MET A CE  1 ? 
ATOM   531  N N   . THR A 1 69  ? 21.625  -7.301  10.191 1.000 29.951  0 69  THR A N   1 ? 
ATOM   532  C CA  . THR A 1 69  ? 21.896  -8.588  10.794 1.000 34.473  0 69  THR A CA  1 ? 
ATOM   533  C C   . THR A 1 69  ? 23.144  -9.194  10.170 1.000 36.330  0 69  THR A C   1 ? 
ATOM   534  O O   . THR A 1 69  ? 23.974  -9.736  10.889 1.000 35.223  0 69  THR A O   1 ? 
ATOM   535  C CB  . THR A 1 69  ? 20.679  -9.504  10.750 1.000 36.857  0 69  THR A CB  1 ? 
ATOM   536  O OG1 . THR A 1 69  ? 19.628  -8.865  11.480 1.000 44.947  0 69  THR A OG1 1 ? 
ATOM   537  C CG2 . THR A 1 69  ? 20.974  -10.838 11.388 1.000 37.803  0 69  THR A CG2 1 ? 
ATOM   538  N N   . GLU A 1 70  ? 23.291  -9.051  8.847  1.000 39.854  0 70  GLU A N   1 ? 
ATOM   539  C CA  . GLU A 1 70  ? 24.464  -9.552  8.160  1.000 41.517  0 70  GLU A CA  1 ? 
ATOM   540  C C   . GLU A 1 70  ? 25.700  -8.976  8.840  1.000 49.325  0 70  GLU A C   1 ? 
ATOM   541  O O   . GLU A 1 70  ? 26.576  -9.738  9.247  1.000 66.861  0 70  GLU A O   1 ? 
ATOM   542  C CB  . GLU A 1 70  ? 24.434  -9.254  6.655  1.000 46.637  0 70  GLU A CB  1 ? 
ATOM   543  C CG  . GLU A 1 70  ? 23.537  -10.206 5.861  1.000 58.798  0 70  GLU A CG  1 ? 
ATOM   544  C CD  . GLU A 1 70  ? 23.769  -10.345 4.354  1.000 64.858  0 70  GLU A CD  1 ? 
ATOM   545  O OE1 . GLU A 1 70  ? 22.827  -10.821 3.659  1.000 61.633  0 70  GLU A OE1 1 ? 
ATOM   546  O OE2 . GLU A 1 70  ? 24.893  -10.041 3.864  1.000 67.739  0 70  GLU A OE2 1 ? 
ATOM   547  N N   . LEU A 1 71  ? 25.733  -7.647  9.008  1.000 48.706  0 71  LEU A N   1 ? 
ATOM   548  C CA  . LEU A 1 71  ? 26.880  -6.946  9.570  1.000 41.622  0 71  LEU A CA  1 ? 
ATOM   549  C C   . LEU A 1 71  ? 27.155  -7.373  11.012 1.000 36.172  0 71  LEU A C   1 ? 
ATOM   550  O O   . LEU A 1 71  ? 28.309  -7.563  11.406 1.000 32.133  0 71  LEU A O   1 ? 
ATOM   551  C CB  . LEU A 1 71  ? 26.609  -5.442  9.503  1.000 38.171  0 71  LEU A CB  1 ? 
ATOM   552  C CG  . LEU A 1 71  ? 26.558  -4.851  8.092  1.000 37.516  0 71  LEU A CG  1 ? 
ATOM   553  C CD1 . LEU A 1 71  ? 26.425  -3.323  8.133  1.000 32.668  0 71  LEU A CD1 1 ? 
ATOM   554  C CD2 . LEU A 1 71  ? 27.785  -5.247  7.262  1.000 35.888  0 71  LEU A CD2 1 ? 
ATOM   555  N N   . LYS A 1 72  ? 26.104  -7.529  11.808 1.000 38.307  0 72  LYS A N   1 ? 
ATOM   556  C CA  . LYS A 1 72  ? 26.303  -7.838  13.216 1.000 45.817  0 72  LYS A CA  1 ? 
ATOM   557  C C   . LYS A 1 72  ? 27.015  -9.195  13.386 1.000 47.950  0 72  LYS A C   1 ? 
ATOM   558  O O   . LYS A 1 72  ? 27.989  -9.300  14.132 1.000 46.002  0 72  LYS A O   1 ? 
ATOM   559  C CB  . LYS A 1 72  ? 24.967  -7.776  13.964 1.000 48.240  0 72  LYS A CB  1 ? 
ATOM   560  C CG  . LYS A 1 72  ? 25.126  -7.608  15.467 1.000 56.556  0 72  LYS A CG  1 ? 
ATOM   561  C CD  . LYS A 1 72  ? 23.830  -7.523  16.232 1.000 60.889  0 72  LYS A CD  1 ? 
ATOM   562  C CE  . LYS A 1 72  ? 24.056  -7.544  17.729 1.000 62.913  0 72  LYS A CE  1 ? 
ATOM   563  N NZ  . LYS A 1 72  ? 22.867  -8.046  18.455 1.000 65.543  0 72  LYS A NZ  1 ? 
ATOM   564  N N   . GLU A 1 73  ? 26.545  -10.228 12.677 1.000 43.929  0 73  GLU A N   1 ? 
ATOM   565  C CA  . GLU A 1 73  ? 27.092  -11.573 12.774 1.000 45.722  0 73  GLU A CA  1 ? 
ATOM   566  C C   . GLU A 1 73  ? 28.551  -11.574 12.315 1.000 47.034  0 73  GLU A C   1 ? 
ATOM   567  O O   . GLU A 1 73  ? 29.326  -12.434 12.732 1.000 54.080  0 73  GLU A O   1 ? 
ATOM   568  C CB  . GLU A 1 73  ? 26.246  -12.557 11.948 1.000 40.558  0 73  GLU A CB  1 ? 
ATOM   569  N N   . LYS A 1 74  ? 28.919  -10.617 11.450 1.000 43.980  0 74  LYS A N   1 ? 
ATOM   570  C CA  . LYS A 1 74  ? 30.299  -10.458 10.997 1.000 41.693  0 74  LYS A CA  1 ? 
ATOM   571  C C   . LYS A 1 74  ? 31.066  -9.530  11.955 1.000 41.595  0 74  LYS A C   1 ? 
ATOM   572  O O   . LYS A 1 74  ? 32.217  -9.202  11.714 1.000 41.484  0 74  LYS A O   1 ? 
ATOM   573  C CB  . LYS A 1 74  ? 30.295  -9.966  9.541  1.000 33.800  0 74  LYS A CB  1 ? 
ATOM   574  N N   . GLY A 1 75  ? 30.411  -9.082  13.032 1.000 44.605  0 75  GLY A N   1 ? 
ATOM   575  C CA  . GLY A 1 75  ? 31.017  -8.254  14.060 1.000 48.951  0 75  GLY A CA  1 ? 
ATOM   576  C C   . GLY A 1 75  ? 31.441  -6.865  13.577 1.000 46.946  0 75  GLY A C   1 ? 
ATOM   577  O O   . GLY A 1 75  ? 32.430  -6.347  14.080 1.000 44.870  0 75  GLY A O   1 ? 
ATOM   578  N N   . GLU A 1 76  ? 30.686  -6.266  12.643 1.000 41.541  0 76  GLU A N   1 ? 
ATOM   579  C CA  . GLU A 1 76  ? 31.104  -5.061  11.947 1.000 38.810  0 76  GLU A CA  1 ? 
ATOM   580  C C   . GLU A 1 76  ? 29.927  -4.088  11.729 1.000 36.853  0 76  GLU A C   1 ? 
ATOM   581  O O   . GLU A 1 76  ? 29.929  -3.294  10.790 1.000 36.119  0 76  GLU A O   1 ? 
ATOM   582  C CB  . GLU A 1 76  ? 31.763  -5.489  10.633 1.000 37.312  0 76  GLU A CB  1 ? 
ATOM   583  N N   . LEU A 1 77  ? 28.921  -4.118  12.611 1.000 33.480  0 77  LEU A N   1 ? 
ATOM   584  C CA  . LEU A 1 77  ? 27.749  -3.257  12.501 1.000 35.410  0 77  LEU A CA  1 ? 
ATOM   585  C C   . LEU A 1 77  ? 28.055  -1.847  13.003 1.000 35.035  0 77  LEU A C   1 ? 
ATOM   586  O O   . LEU A 1 77  ? 27.658  -0.872  12.382 1.000 38.810  0 77  LEU A O   1 ? 
ATOM   587  C CB  . LEU A 1 77  ? 26.611  -3.868  13.313 1.000 33.990  0 77  LEU A CB  1 ? 
ATOM   588  C CG  . LEU A 1 77  ? 25.380  -2.999  13.512 1.000 34.092  0 77  LEU A CG  1 ? 
ATOM   589  C CD1 . LEU A 1 77  ? 24.650  -2.792  12.202 1.000 39.119  0 77  LEU A CD1 1 ? 
ATOM   590  C CD2 . LEU A 1 77  ? 24.466  -3.647  14.517 1.000 36.460  0 77  LEU A CD2 1 ? 
ATOM   591  N N   . SER A 1 78  ? 28.755  -1.752  14.132 1.000 36.065  0 78  SER A N   1 ? 
ATOM   592  C CA  . SER A 1 78  ? 29.212  -0.490  14.689 1.000 41.309  0 78  SER A CA  1 ? 
ATOM   593  C C   . SER A 1 78  ? 29.808  0.410   13.621 1.000 46.231  0 78  SER A C   1 ? 
ATOM   594  O O   . SER A 1 78  ? 29.633  1.632   13.663 1.000 44.364  0 78  SER A O   1 ? 
ATOM   595  C CB  . SER A 1 78  ? 30.224  -0.734  15.772 1.000 39.816  0 78  SER A CB  1 ? 
ATOM   596  O OG  . SER A 1 78  ? 29.573  -1.051  16.992 1.000 42.638  0 78  SER A OG  1 ? 
ATOM   597  N N   . THR A 1 79  ? 30.555  -0.221  12.701 1.000 50.709  0 79  THR A N   1 ? 
ATOM   598  C CA  . THR A 1 79  ? 31.450  0.522   11.830 1.000 57.020  0 79  THR A CA  1 ? 
ATOM   599  C C   . THR A 1 79  ? 30.877  0.683   10.420 1.000 51.507  0 79  THR A C   1 ? 
ATOM   600  O O   . THR A 1 79  ? 31.435  1.460   9.658  1.000 53.466  0 79  THR A O   1 ? 
ATOM   601  C CB  . THR A 1 79  ? 32.853  -0.105  11.825 1.000 59.932  0 79  THR A CB  1 ? 
ATOM   602  O OG1 . THR A 1 79  ? 32.774  -1.465  11.395 1.000 68.399  0 79  THR A OG1 1 ? 
ATOM   603  C CG2 . THR A 1 79  ? 33.520  -0.055  13.185 1.000 62.225  0 79  THR A CG2 1 ? 
ATOM   604  N N   . ARG A 1 80  ? 29.783  -0.015  10.070 1.000 50.657  0 80  ARG A N   1 ? 
ATOM   605  C CA  . ARG A 1 80  ? 29.252  0.025   8.711  1.000 53.269  0 80  ARG A CA  1 ? 
ATOM   606  C C   . ARG A 1 80  ? 27.732  0.181   8.700  1.000 46.752  0 80  ARG A C   1 ? 
ATOM   607  O O   . ARG A 1 80  ? 27.096  -0.036  7.670  1.000 37.245  0 80  ARG A O   1 ? 
ATOM   608  C CB  . ARG A 1 80  ? 29.648  -1.241  7.940  1.000 57.670  0 80  ARG A CB  1 ? 
ATOM   609  C CG  . ARG A 1 80  ? 31.142  -1.339  7.664  1.000 61.506  0 80  ARG A CG  1 ? 
ATOM   610  C CD  . ARG A 1 80  ? 31.592  -2.733  7.251  1.000 67.985  0 80  ARG A CD  1 ? 
ATOM   611  N NE  . ARG A 1 80  ? 30.689  -3.453  6.356  1.000 62.499  0 80  ARG A NE  1 ? 
ATOM   612  C CZ  . ARG A 1 80  ? 31.004  -3.899  5.145  1.000 62.923  0 80  ARG A CZ  1 ? 
ATOM   613  N NH1 . ARG A 1 80  ? 32.043  -3.406  4.495  1.000 67.868  0 80  ARG A NH1 1 ? 
ATOM   614  N NH2 . ARG A 1 80  ? 30.231  -4.790  4.553  1.000 66.397  0 80  ARG A NH2 1 ? 
ATOM   615  N N   . LEU A 1 81  ? 27.164  0.593   9.833  1.000 44.144  0 81  LEU A N   1 ? 
ATOM   616  C CA  . LEU A 1 81  ? 25.725  0.757   9.960  1.000 49.805  0 81  LEU A CA  1 ? 
ATOM   617  C C   . LEU A 1 81  ? 25.155  1.664   8.870  1.000 49.718  0 81  LEU A C   1 ? 
ATOM   618  O O   . LEU A 1 81  ? 24.051  1.422   8.415  1.000 48.555  0 81  LEU A O   1 ? 
ATOM   619  C CB  . LEU A 1 81  ? 25.430  1.359   11.333 1.000 49.491  0 81  LEU A CB  1 ? 
ATOM   620  C CG  . LEU A 1 81  ? 23.972  1.710   11.581 1.000 43.404  0 81  LEU A CG  1 ? 
ATOM   621  C CD1 . LEU A 1 81  ? 23.190  0.456   11.859 1.000 42.812  0 81  LEU A CD1 1 ? 
ATOM   622  C CD2 . LEU A 1 81  ? 23.834  2.694   12.719 1.000 47.748  0 81  LEU A CD2 1 ? 
ATOM   623  N N   . GLY A 1 82  ? 25.875  2.732   8.498  1.000 50.354  0 82  GLY A N   1 ? 
ATOM   624  C CA  . GLY A 1 82  ? 25.426  3.674   7.472  1.000 45.260  0 82  GLY A CA  1 ? 
ATOM   625  C C   . GLY A 1 82  ? 25.419  3.057   6.076  1.000 44.203  0 82  GLY A C   1 ? 
ATOM   626  O O   . GLY A 1 82  ? 24.718  3.520   5.186  1.000 38.581  0 82  GLY A O   1 ? 
ATOM   627  N N   . GLU A 1 83  ? 26.225  2.002   5.895  1.000 54.391  0 83  GLU A N   1 ? 
ATOM   628  C CA  . GLU A 1 83  ? 26.103  1.117   4.741  1.000 47.833  0 83  GLU A CA  1 ? 
ATOM   629  C C   . GLU A 1 83  ? 24.694  0.520   4.672  1.000 37.409  0 83  GLU A C   1 ? 
ATOM   630  O O   . GLU A 1 83  ? 24.081  0.558   3.623  1.000 40.121  0 83  GLU A O   1 ? 
ATOM   631  C CB  . GLU A 1 83  ? 27.186  0.033   4.751  1.000 45.609  0 83  GLU A CB  1 ? 
ATOM   632  C CG  . GLU A 1 83  ? 28.491  0.482   4.124  1.000 51.461  0 83  GLU A CG  1 ? 
ATOM   633  C CD  . GLU A 1 83  ? 29.660  -0.454  4.388  1.000 55.517  0 83  GLU A CD  1 ? 
ATOM   634  O OE1 . GLU A 1 83  ? 30.666  0.019   4.949  1.000 51.819  0 83  GLU A OE1 1 ? 
ATOM   635  O OE2 . GLU A 1 83  ? 29.566  -1.662  4.039  1.000 55.707  0 83  GLU A OE2 1 ? 
ATOM   636  N N   . ALA A 1 84  ? 24.156  0.009   5.786  1.000 37.355  0 84  ALA A N   1 ? 
ATOM   637  C CA  . ALA A 1 84  ? 22.814  -0.576  5.810  1.000 36.102  0 84  ALA A CA  1 ? 
ATOM   638  C C   . ALA A 1 84  ? 21.746  0.451   5.451  1.000 31.014  0 84  ALA A C   1 ? 
ATOM   639  O O   . ALA A 1 84  ? 20.795  0.158   4.733  1.000 34.446  0 84  ALA A O   1 ? 
ATOM   640  C CB  . ALA A 1 84  ? 22.547  -1.161  7.168  1.000 37.866  0 84  ALA A CB  1 ? 
ATOM   641  N N   . PHE A 1 85  ? 21.947  1.678   5.926  1.000 30.545  0 85  PHE A N   1 ? 
ATOM   642  C CA  . PHE A 1 85  ? 20.998  2.750   5.726  1.000 32.823  0 85  PHE A CA  1 ? 
ATOM   643  C C   . PHE A 1 85  ? 20.981  3.191   4.273  1.000 33.681  0 85  PHE A C   1 ? 
ATOM   644  O O   . PHE A 1 85  ? 19.976  3.715   3.795  1.000 35.463  0 85  PHE A O   1 ? 
ATOM   645  C CB  . PHE A 1 85  ? 21.300  3.900   6.693  1.000 36.854  0 85  PHE A CB  1 ? 
ATOM   646  C CG  . PHE A 1 85  ? 20.549  3.779   7.999  1.000 36.813  0 85  PHE A CG  1 ? 
ATOM   647  C CD1 . PHE A 1 85  ? 19.215  4.138   8.083  1.000 35.659  0 85  PHE A CD1 1 ? 
ATOM   648  C CD2 . PHE A 1 85  ? 21.150  3.241   9.124  1.000 36.910  0 85  PHE A CD2 1 ? 
ATOM   649  C CE1 . PHE A 1 85  ? 18.514  4.005   9.272  1.000 40.347  0 85  PHE A CE1 1 ? 
ATOM   650  C CE2 . PHE A 1 85  ? 20.435  3.082   10.302 1.000 37.694  0 85  PHE A CE2 1 ? 
ATOM   651  C CZ  . PHE A 1 85  ? 19.114  3.453   10.374 1.000 37.166  0 85  PHE A CZ  1 ? 
ATOM   652  N N   . SER A 1 86  ? 22.087  2.946   3.577  1.000 39.121  0 86  SER A N   1 ? 
ATOM   653  C CA  . SER A 1 86  ? 22.322  3.420   2.231  1.000 41.013  0 86  SER A CA  1 ? 
ATOM   654  C C   . SER A 1 86  ? 21.314  2.792   1.269  1.000 40.234  0 86  SER A C   1 ? 
ATOM   655  O O   . SER A 1 86  ? 20.903  3.439   0.310  1.000 46.217  0 86  SER A O   1 ? 
ATOM   656  C CB  . SER A 1 86  ? 23.774  3.119   1.889  1.000 47.995  0 86  SER A CB  1 ? 
ATOM   657  O OG  . SER A 1 86  ? 24.144  3.667   0.637  1.000 67.513  0 86  SER A OG  1 ? 
ATOM   658  N N   . GLN A 1 87  ? 20.921  1.536   1.521  1.000 36.445  0 87  GLN A N   1 ? 
ATOM   659  C CA  . GLN A 1 87  ? 19.915  0.916   0.678  1.000 39.181  0 87  GLN A CA  1 ? 
ATOM   660  C C   . GLN A 1 87  ? 18.540  1.393   1.109  1.000 38.214  0 87  GLN A C   1 ? 
ATOM   661  O O   . GLN A 1 87  ? 17.636  1.472   0.299  1.000 45.757  0 87  GLN A O   1 ? 
ATOM   662  C CB  . GLN A 1 87  ? 19.892  -0.613  0.762  1.000 47.229  0 87  GLN A CB  1 ? 
ATOM   663  C CG  . GLN A 1 87  ? 21.198  -1.275  0.376  1.000 52.946  0 87  GLN A CG  1 ? 
ATOM   664  C CD  . GLN A 1 87  ? 22.101  -1.411  1.573  1.000 69.599  0 87  GLN A CD  1 ? 
ATOM   665  O OE1 . GLN A 1 87  ? 21.628  -1.614  2.692  1.000 74.792  0 87  GLN A OE1 1 ? 
ATOM   666  N NE2 . GLN A 1 87  ? 23.404  -1.284  1.352  1.000 78.472  0 87  GLN A NE2 1 ? 
ATOM   667  N N   . PHE A 1 88  ? 18.380  1.666   2.405  1.000 34.967  0 88  PHE A N   1 ? 
ATOM   668  C CA  . PHE A 1 88  ? 17.076  1.935   2.975  1.000 30.184  0 88  PHE A CA  1 ? 
ATOM   669  C C   . PHE A 1 88  ? 16.617  3.342   2.619  1.000 30.848  0 88  PHE A C   1 ? 
ATOM   670  O O   . PHE A 1 88  ? 15.501  3.494   2.135  1.000 26.199  0 88  PHE A O   1 ? 
ATOM   671  C CB  . PHE A 1 88  ? 17.165  1.771   4.490  1.000 29.636  0 88  PHE A CB  1 ? 
ATOM   672  C CG  . PHE A 1 88  ? 15.916  2.058   5.275  1.000 27.835  0 88  PHE A CG  1 ? 
ATOM   673  C CD1 . PHE A 1 88  ? 14.817  1.227   5.196  1.000 29.215  0 88  PHE A CD1 1 ? 
ATOM   674  C CD2 . PHE A 1 88  ? 15.882  3.110   6.176  1.000 32.296  0 88  PHE A CD2 1 ? 
ATOM   675  C CE1 . PHE A 1 88  ? 13.702  1.467   5.989  1.000 33.438  0 88  PHE A CE1 1 ? 
ATOM   676  C CE2 . PHE A 1 88  ? 14.764  3.350   6.959  1.000 32.124  0 88  PHE A CE2 1 ? 
ATOM   677  C CZ  . PHE A 1 88  ? 13.673  2.540   6.851  1.000 30.400  0 88  PHE A CZ  1 ? 
ATOM   678  N N   . ILE A 1 89  ? 17.473  4.354   2.873  1.000 29.913  0 89  ILE A N   1 ? 
ATOM   679  C CA  . ILE A 1 89  ? 16.981  5.721   2.947  1.000 33.748  0 89  ILE A CA  1 ? 
ATOM   680  C C   . ILE A 1 89  ? 16.332  6.093   1.614  1.000 33.640  0 89  ILE A C   1 ? 
ATOM   681  O O   . ILE A 1 89  ? 15.331  6.791   1.576  1.000 36.914  0 89  ILE A O   1 ? 
ATOM   682  C CB  . ILE A 1 89  ? 18.045  6.742   3.428  1.000 38.399  0 89  ILE A CB  1 ? 
ATOM   683  C CG1 . ILE A 1 89  ? 19.322  6.750   2.579  1.000 46.416  0 89  ILE A CG1 1 ? 
ATOM   684  C CG2 . ILE A 1 89  ? 18.372  6.541   4.905  1.000 31.675  0 89  ILE A CG2 1 ? 
ATOM   685  C CD1 . ILE A 1 89  ? 20.367  7.751   3.018  1.000 45.736  0 89  ILE A CD1 1 ? 
ATOM   686  N N   . PRO A 1 90  ? 16.817  5.636   0.451  1.000 34.621  0 90  PRO A N   1 ? 
ATOM   687  C CA  . PRO A 1 90  ? 16.192  6.083   -0.788 1.000 38.849  0 90  PRO A CA  1 ? 
ATOM   688  C C   . PRO A 1 90  ? 14.894  5.336   -1.122 1.000 37.962  0 90  PRO A C   1 ? 
ATOM   689  O O   . PRO A 1 90  ? 14.206  5.699   -2.070 1.000 37.202  0 90  PRO A O   1 ? 
ATOM   690  C CB  . PRO A 1 90  ? 17.349  5.892   -1.796 1.000 38.080  0 90  PRO A CB  1 ? 
ATOM   691  C CG  . PRO A 1 90  ? 18.148  4.725   -1.258 1.000 35.958  0 90  PRO A CG  1 ? 
ATOM   692  C CD  . PRO A 1 90  ? 17.980  4.759   0.245  1.000 34.410  0 90  PRO A CD  1 ? 
ATOM   693  N N   . MET A 1 91  ? 14.555  4.297   -0.356 1.000 36.397  0 91  MET A N   1 ? 
ATOM   694  C CA  . MET A 1 91  ? 13.276  3.598   -0.500 1.000 40.154  0 91  MET A CA  1 ? 
ATOM   695  C C   . MET A 1 91  ? 12.163  4.237   0.333  1.000 34.640  0 91  MET A C   1 ? 
ATOM   696  O O   . MET A 1 91  ? 11.053  3.733   0.304  1.000 30.772  0 91  MET A O   1 ? 
ATOM   697  C CB  . MET A 1 91  ? 13.371  2.142   -0.025 1.000 44.171  0 91  MET A CB  1 ? 
ATOM   698  C CG  . MET A 1 91  ? 14.434  1.359   -0.701 1.000 46.380  0 91  MET A CG  1 ? 
ATOM   699  S SD  . MET A 1 91  ? 14.208  1.374   -2.484 1.000 59.713  0 91  MET A SD  1 ? 
ATOM   700  C CE  . MET A 1 91  ? 14.158  -0.397  -2.769 1.000 56.495  0 91  MET A CE  1 ? 
ATOM   701  N N   . MET A 1 92  ? 12.475  5.346   1.013  1.000 37.430  0 92  MET A N   1 ? 
ATOM   702  C CA  . MET A 1 92  ? 11.626  6.039   1.975  1.000 44.961  0 92  MET A CA  1 ? 
ATOM   703  C C   . MET A 1 92  ? 10.254  6.452   1.442  1.000 47.293  0 92  MET A C   1 ? 
ATOM   704  O O   . MET A 1 92  ? 9.308   6.538   2.235  1.000 44.444  0 92  MET A O   1 ? 
ATOM   705  C CB  . MET A 1 92  ? 12.308  7.322   2.476  1.000 53.296  0 92  MET A CB  1 ? 
ATOM   706  C CG  . MET A 1 92  ? 12.178  7.570   3.983  1.000 55.349  0 92  MET A CG  1 ? 
ATOM   707  S SD  . MET A 1 92  ? 13.474  6.799   5.000  1.000 45.838  0 92  MET A SD  1 ? 
ATOM   708  C CE  . MET A 1 92  ? 13.424  5.105   4.451  1.000 42.311  0 92  MET A CE  1 ? 
ATOM   709  N N   . ASN A 1 93  ? 10.129  6.733   0.140  1.000 42.718  0 93  ASN A N   1 ? 
ATOM   710  C CA  . ASN A 1 93  ? 8.888   7.293   -0.377 1.000 45.731  0 93  ASN A CA  1 ? 
ATOM   711  C C   . ASN A 1 93  ? 7.684   6.454   0.067  1.000 42.573  0 93  ASN A C   1 ? 
ATOM   712  O O   . ASN A 1 93  ? 6.562   6.956   0.123  1.000 38.399  0 93  ASN A O   1 ? 
ATOM   713  C CB  . ASN A 1 93  ? 8.916   7.419   -1.902 1.000 54.948  0 93  ASN A CB  1 ? 
ATOM   714  C CG  . ASN A 1 93  ? 7.811   8.310   -2.434 1.000 60.382  0 93  ASN A CG  1 ? 
ATOM   715  O OD1 . ASN A 1 93  ? 7.769   9.509   -2.136 1.000 64.375  0 93  ASN A OD1 1 ? 
ATOM   716  N ND2 . ASN A 1 93  ? 6.920   7.729   -3.221 1.000 57.511  0 93  ASN A ND2 1 ? 
ATOM   717  N N   . VAL A 1 94  ? 7.915   5.168   0.369  1.000 38.305  0 94  VAL A N   1 ? 
ATOM   718  C CA  . VAL A 1 94  ? 6.842   4.344   0.890  1.000 35.131  0 94  VAL A CA  1 ? 
ATOM   719  C C   . VAL A 1 94  ? 6.391   4.851   2.246  1.000 29.085  0 94  VAL A C   1 ? 
ATOM   720  O O   . VAL A 1 94  ? 5.217   4.744   2.575  1.000 29.120  0 94  VAL A O   1 ? 
ATOM   721  C CB  . VAL A 1 94  ? 7.204   2.859   0.991  1.000 37.072  0 94  VAL A CB  1 ? 
ATOM   722  C CG1 . VAL A 1 94  ? 7.640   2.313   -0.355 1.000 38.823  0 94  VAL A CG1 1 ? 
ATOM   723  C CG2 . VAL A 1 94  ? 8.240   2.599   2.063  1.000 39.173  0 94  VAL A CG2 1 ? 
ATOM   724  N N   . TYR A 1 95  ? 7.314   5.397   3.028  1.000 29.715  0 95  TYR A N   1 ? 
ATOM   725  C CA  . TYR A 1 95  ? 6.920   6.053   4.269  1.000 32.190  0 95  TYR A CA  1 ? 
ATOM   726  C C   . TYR A 1 95  ? 6.045   7.275   3.968  1.000 32.872  0 95  TYR A C   1 ? 
ATOM   727  O O   . TYR A 1 95  ? 5.096   7.533   4.697  1.000 36.936  0 95  TYR A O   1 ? 
ATOM   728  C CB  . TYR A 1 95  ? 8.130   6.426   5.133  1.000 28.482  0 95  TYR A CB  1 ? 
ATOM   729  C CG  . TYR A 1 95  ? 8.615   5.359   6.087  1.000 27.420  0 95  TYR A CG  1 ? 
ATOM   730  C CD1 . TYR A 1 95  ? 8.096   5.249   7.369  1.000 25.092  0 95  TYR A CD1 1 ? 
ATOM   731  C CD2 . TYR A 1 95  ? 9.620   4.467   5.722  1.000 26.401  0 95  TYR A CD2 1 ? 
ATOM   732  C CE1 . TYR A 1 95  ? 8.561   4.301   8.269  1.000 23.581  0 95  TYR A CE1 1 ? 
ATOM   733  C CE2 . TYR A 1 95  ? 10.071  3.495   6.597  1.000 25.478  0 95  TYR A CE2 1 ? 
ATOM   734  C CZ  . TYR A 1 95  ? 9.547   3.420   7.877  1.000 24.783  0 95  TYR A CZ  1 ? 
ATOM   735  O OH  . TYR A 1 95  ? 9.996   2.457   8.744  1.000 30.687  0 95  TYR A OH  1 ? 
ATOM   736  N N   . LYS A 1 96  ? 6.346   8.020   2.901  1.000 34.122  0 96  LYS A N   1 ? 
ATOM   737  C CA  . LYS A 1 96  ? 5.527   9.164   2.507  1.000 40.861  0 96  LYS A CA  1 ? 
ATOM   738  C C   . LYS A 1 96  ? 4.098   8.713   2.224  1.000 36.987  0 96  LYS A C   1 ? 
ATOM   739  O O   . LYS A 1 96  ? 3.153   9.353   2.678  1.000 41.190  0 96  LYS A O   1 ? 
ATOM   740  C CB  . LYS A 1 96  ? 6.064   9.889   1.261  1.000 44.547  0 96  LYS A CB  1 ? 
ATOM   741  C CG  . LYS A 1 96  ? 6.312   11.379  1.451  1.000 43.097  0 96  LYS A CG  1 ? 
ATOM   742  N N   . LEU A 1 97  ? 3.974   7.622   1.463  1.000 31.917  0 97  LEU A N   1 ? 
ATOM   743  C CA  . LEU A 1 97  ? 2.684   7.111   1.043  1.000 28.731  0 97  LEU A CA  1 ? 
ATOM   744  C C   . LEU A 1 97  ? 1.928   6.600   2.256  1.000 29.219  0 97  LEU A C   1 ? 
ATOM   745  O O   . LEU A 1 97  ? 0.728   6.825   2.377  1.000 29.517  0 97  LEU A O   1 ? 
ATOM   746  C CB  . LEU A 1 97  ? 2.896   6.001   0.017  1.000 29.751  0 97  LEU A CB  1 ? 
ATOM   747  C CG  . LEU A 1 97  ? 3.593   6.458   -1.272 1.000 31.954  0 97  LEU A CG  1 ? 
ATOM   748  C CD1 . LEU A 1 97  ? 3.850   5.299   -2.223 1.000 28.748  0 97  LEU A CD1 1 ? 
ATOM   749  C CD2 . LEU A 1 97  ? 2.787   7.532   -1.985 1.000 32.844  0 97  LEU A CD2 1 ? 
ATOM   750  N N   . PHE A 1 98  ? 2.635   5.930   3.163  1.000 30.144  0 98  PHE A N   1 ? 
ATOM   751  C CA  . PHE A 1 98  ? 1.960   5.412   4.341  1.000 33.754  0 98  PHE A CA  1 ? 
ATOM   752  C C   . PHE A 1 98  ? 1.464   6.574   5.213  1.000 32.943  0 98  PHE A C   1 ? 
ATOM   753  O O   . PHE A 1 98  ? 0.276   6.688   5.518  1.000 32.655  0 98  PHE A O   1 ? 
ATOM   754  C CB  . PHE A 1 98  ? 2.873   4.441   5.084  1.000 33.751  0 98  PHE A CB  1 ? 
ATOM   755  C CG  . PHE A 1 98  ? 2.200   3.833   6.280  1.000 34.516  0 98  PHE A CG  1 ? 
ATOM   756  C CD1 . PHE A 1 98  ? 1.364   2.737   6.134  1.000 36.717  0 98  PHE A CD1 1 ? 
ATOM   757  C CD2 . PHE A 1 98  ? 2.369   4.379   7.546  1.000 36.172  0 98  PHE A CD2 1 ? 
ATOM   758  C CE1 . PHE A 1 98  ? 0.719   2.190   7.234  1.000 34.727  0 98  PHE A CE1 1 ? 
ATOM   759  C CE2 . PHE A 1 98  ? 1.735   3.822   8.654  1.000 34.629  0 98  PHE A CE2 1 ? 
ATOM   760  C CZ  . PHE A 1 98  ? 0.911   2.725   8.494  1.000 33.495  0 98  PHE A CZ  1 ? 
ATOM   761  N N   . LEU A 1 99  ? 2.387   7.457   5.598  1.000 35.223  0 99  LEU A N   1 ? 
ATOM   762  C CA  . LEU A 1 99  ? 2.046   8.681   6.308  1.000 34.447  0 99  LEU A CA  1 ? 
ATOM   763  C C   . LEU A 1 99  ? 0.878   9.368   5.620  1.000 31.727  0 99  LEU A C   1 ? 
ATOM   764  O O   . LEU A 1 99  ? -0.096  9.740   6.266  1.000 33.183  0 99  LEU A O   1 ? 
ATOM   765  C CB  . LEU A 1 99  ? 3.263   9.605   6.333  1.000 37.339  0 99  LEU A CB  1 ? 
ATOM   766  C CG  . LEU A 1 99  ? 4.096   9.556   7.608  1.000 42.313  0 99  LEU A CG  1 ? 
ATOM   767  C CD1 . LEU A 1 99  ? 4.360   8.122   8.047  1.000 44.891  0 99  LEU A CD1 1 ? 
ATOM   768  C CD2 . LEU A 1 99  ? 5.409   10.300  7.400  1.000 45.620  0 99  LEU A CD2 1 ? 
ATOM   769  N N   . GLY A 1 100 ? 0.983   9.483   4.295  1.000 29.112  0 100 GLY A N   1 ? 
ATOM   770  C CA  . GLY A 1 100 ? 0.011   10.213  3.507  1.000 29.128  0 100 GLY A CA  1 ? 
ATOM   771  C C   . GLY A 1 100 ? -1.391  9.634   3.650  1.000 32.555  0 100 GLY A C   1 ? 
ATOM   772  O O   . GLY A 1 100 ? -2.366  10.333  3.381  1.000 31.788  0 100 GLY A O   1 ? 
ATOM   773  N N   . ASN A 1 101 ? -1.475  8.340   4.001  1.000 33.106  0 101 ASN A N   1 ? 
ATOM   774  C CA  . ASN A 1 101 ? -2.745  7.642   3.999  1.000 33.490  0 101 ASN A CA  1 ? 
ATOM   775  C C   . ASN A 1 101 ? -3.321  7.610   5.418  1.000 37.038  0 101 ASN A C   1 ? 
ATOM   776  O O   . ASN A 1 101 ? -4.383  7.036   5.656  1.000 43.633  0 101 ASN A O   1 ? 
ATOM   777  C CB  . ASN A 1 101 ? -2.570  6.234   3.416  1.000 33.175  0 101 ASN A CB  1 ? 
ATOM   778  C CG  . ASN A 1 101 ? -3.895  5.539   3.161  1.000 33.459  0 101 ASN A CG  1 ? 
ATOM   779  O OD1 . ASN A 1 101 ? -4.697  6.052   2.386  1.000 35.285  0 101 ASN A OD1 1 ? 
ATOM   780  N ND2 . ASN A 1 101 ? -4.142  4.397   3.798  1.000 31.728  0 101 ASN A ND2 1 ? 
ATOM   781  N N   . SER A 1 102 ? -2.626  8.183   6.401  1.000 37.078  0 102 SER A N   1 ? 
ATOM   782  C CA  . SER A 1 102 ? -3.017  7.918   7.771  1.000 41.995  0 102 SER A CA  1 ? 
ATOM   783  C C   . SER A 1 102 ? -4.412  8.463   8.089  1.000 39.864  0 102 SER A C   1 ? 
ATOM   784  O O   . SER A 1 102 ? -5.189  7.804   8.772  1.000 37.720  0 102 SER A O   1 ? 
ATOM   785  C CB  . SER A 1 102 ? -1.987  8.416   8.716  1.000 45.924  0 102 SER A CB  1 ? 
ATOM   786  O OG  . SER A 1 102 ? -2.062  7.664   9.915  1.000 54.400  0 102 SER A OG  1 ? 
ATOM   787  N N   . ASP A 1 103 ? -4.712  9.666   7.597  1.000 42.416  0 103 ASP A N   1 ? 
ATOM   788  C CA  . ASP A 1 103 ? -6.027  10.277  7.740  1.000 45.671  0 103 ASP A CA  1 ? 
ATOM   789  C C   . ASP A 1 103 ? -7.141  9.351   7.248  1.000 39.509  0 103 ASP A C   1 ? 
ATOM   790  O O   . ASP A 1 103 ? -8.100  9.103   7.980  1.000 40.955  0 103 ASP A O   1 ? 
ATOM   791  C CB  . ASP A 1 103 ? -6.114  11.610  6.988  1.000 51.358  0 103 ASP A CB  1 ? 
ATOM   792  C CG  . ASP A 1 103 ? -5.834  12.821  7.856  1.000 59.089  0 103 ASP A CG  1 ? 
ATOM   793  O OD1 . ASP A 1 103 ? -5.668  12.631  9.090  1.000 67.373  0 103 ASP A OD1 1 ? 
ATOM   794  O OD2 . ASP A 1 103 ? -5.797  13.940  7.299  1.000 59.066  0 103 ASP A OD2 1 ? 
ATOM   795  N N   . THR A 1 104 ? -7.019  8.879   6.003  1.000 32.311  0 104 THR A N   1 ? 
ATOM   796  C CA  . THR A 1 104 ? -7.945  7.929   5.417  1.000 29.607  0 104 THR A CA  1 ? 
ATOM   797  C C   . THR A 1 104 ? -8.013  6.630   6.220  1.000 32.378  0 104 THR A C   1 ? 
ATOM   798  O O   . THR A 1 104 ? -9.106  6.166   6.567  1.000 34.773  0 104 THR A O   1 ? 
ATOM   799  C CB  . THR A 1 104 ? -7.547  7.591   3.978  1.000 27.635  0 104 THR A CB  1 ? 
ATOM   800  O OG1 . THR A 1 104 ? -7.634  8.810   3.254  1.000 26.185  0 104 THR A OG1 1 ? 
ATOM   801  C CG2 . THR A 1 104 ? -8.422  6.543   3.324  1.000 26.982  0 104 THR A CG2 1 ? 
ATOM   802  N N   . SER A 1 105 ? -6.857  6.023   6.475  1.000 30.771  0 105 SER A N   1 ? 
ATOM   803  C CA  . SER A 1 105 ? -6.831  4.765   7.186  1.000 32.261  0 105 SER A CA  1 ? 
ATOM   804  C C   . SER A 1 105 ? -7.659  4.896   8.457  1.000 30.724  0 105 SER A C   1 ? 
ATOM   805  O O   . SER A 1 105 ? -8.506  4.061   8.727  1.000 29.506  0 105 SER A O   1 ? 
ATOM   806  C CB  . SER A 1 105 ? -5.412  4.340   7.490  1.000 35.982  0 105 SER A CB  1 ? 
ATOM   807  O OG  . SER A 1 105 ? -5.399  3.170   8.312  1.000 35.777  0 105 SER A OG  1 ? 
ATOM   808  N N   . LEU A 1 106 ? -7.418  5.964   9.225  1.000 36.235  0 106 LEU A N   1 ? 
ATOM   809  C CA  . LEU A 1 106 ? -8.043  6.105   10.533 1.000 37.013  0 106 LEU A CA  1 ? 
ATOM   810  C C   . LEU A 1 106 ? -9.534  6.389   10.382 1.000 36.712  0 106 LEU A C   1 ? 
ATOM   811  O O   . LEU A 1 106 ? -10.323 5.925   11.201 1.000 43.780  0 106 LEU A O   1 ? 
ATOM   812  C CB  . LEU A 1 106 ? -7.360  7.203   11.350 1.000 34.356  0 106 LEU A CB  1 ? 
ATOM   813  N N   . GLN A 1 107 ? -9.908  7.172   9.375  1.000 33.233  0 107 GLN A N   1 ? 
ATOM   814  C CA  . GLN A 1 107 ? -11.314 7.441   9.126  1.000 39.341  0 107 GLN A CA  1 ? 
ATOM   815  C C   . GLN A 1 107 ? -12.061 6.132   8.867  1.000 36.223  0 107 GLN A C   1 ? 
ATOM   816  O O   . GLN A 1 107 ? -13.168 5.907   9.373  1.000 27.135  0 107 GLN A O   1 ? 
ATOM   817  C CB  . GLN A 1 107 ? -11.498 8.391   7.934  1.000 53.434  0 107 GLN A CB  1 ? 
ATOM   818  C CG  . GLN A 1 107 ? -12.060 9.758   8.301  1.000 61.620  0 107 GLN A CG  1 ? 
ATOM   819  C CD  . GLN A 1 107 ? -13.404 9.640   8.987  1.000 62.827  0 107 GLN A CD  1 ? 
ATOM   820  O OE1 . GLN A 1 107 ? -14.233 8.792   8.657  1.000 60.683  0 107 GLN A OE1 1 ? 
ATOM   821  N NE2 . GLN A 1 107 ? -13.625 10.496  9.973  1.000 61.356  0 107 GLN A NE2 1 ? 
ATOM   822  N N   . PHE A 1 108 ? -11.450 5.244   8.077  1.000 35.802  0 108 PHE A N   1 ? 
ATOM   823  C CA  . PHE A 1 108 ? -12.121 3.988   7.784  1.000 36.355  0 108 PHE A CA  1 ? 
ATOM   824  C C   . PHE A 1 108 ? -12.165 3.103   9.037  1.000 33.610  0 108 PHE A C   1 ? 
ATOM   825  O O   . PHE A 1 108 ? -13.180 2.455   9.261  1.000 28.367  0 108 PHE A O   1 ? 
ATOM   826  C CB  . PHE A 1 108 ? -11.507 3.292   6.566  1.000 32.380  0 108 PHE A CB  1 ? 
ATOM   827  C CG  . PHE A 1 108 ? -11.869 3.913   5.246  1.000 32.064  0 108 PHE A CG  1 ? 
ATOM   828  C CD1 . PHE A 1 108 ? -13.168 4.323   4.974  1.000 33.188  0 108 PHE A CD1 1 ? 
ATOM   829  C CD2 . PHE A 1 108 ? -10.910 4.114   4.272  1.000 34.565  0 108 PHE A CD2 1 ? 
ATOM   830  C CE1 . PHE A 1 108 ? -13.495 4.897   3.763  1.000 28.159  0 108 PHE A CE1 1 ? 
ATOM   831  C CE2 . PHE A 1 108 ? -11.242 4.685   3.049  1.000 28.658  0 108 PHE A CE2 1 ? 
ATOM   832  C CZ  . PHE A 1 108 ? -12.527 5.068   2.803  1.000 28.497  0 108 PHE A CZ  1 ? 
ATOM   833  N N   . LEU A 1 109 ? -11.107 3.109   9.864  1.000 30.567  0 109 LEU A N   1 ? 
ATOM   834  C CA  . LEU A 1 109 ? -11.117 2.301   11.080 1.000 35.892  0 109 LEU A CA  1 ? 
ATOM   835  C C   . LEU A 1 109 ? -12.281 2.692   12.006 1.000 35.402  0 109 LEU A C   1 ? 
ATOM   836  O O   . LEU A 1 109 ? -12.989 1.844   12.532 1.000 32.029  0 109 LEU A O   1 ? 
ATOM   837  C CB  . LEU A 1 109 ? -9.770  2.423   11.809 1.000 33.061  0 109 LEU A CB  1 ? 
ATOM   838  C CG  . LEU A 1 109 ? -9.529  1.395   12.929 1.000 32.100  0 109 LEU A CG  1 ? 
ATOM   839  C CD1 . LEU A 1 109 ? -9.871  -0.017  12.475 1.000 29.574  0 109 LEU A CD1 1 ? 
ATOM   840  C CD2 . LEU A 1 109 ? -8.091  1.421   13.448 1.000 31.732  0 109 LEU A CD2 1 ? 
ATOM   841  N N   . VAL A 1 110 ? -12.474 3.993   12.183 1.000 37.391  0 110 VAL A N   1 ? 
ATOM   842  C CA  . VAL A 1 110 ? -13.423 4.545   13.130 1.000 36.985  0 110 VAL A CA  1 ? 
ATOM   843  C C   . VAL A 1 110 ? -14.832 4.248   12.653 1.000 38.768  0 110 VAL A C   1 ? 
ATOM   844  O O   . VAL A 1 110 ? -15.719 4.101   13.483 1.000 44.596  0 110 VAL A O   1 ? 
ATOM   845  C CB  . VAL A 1 110 ? -13.184 6.059   13.299 1.000 39.050  0 110 VAL A CB  1 ? 
ATOM   846  C CG1 . VAL A 1 110 ? -14.379 6.777   13.883 1.000 42.172  0 110 VAL A CG1 1 ? 
ATOM   847  C CG2 . VAL A 1 110 ? -11.950 6.338   14.138 1.000 39.938  0 110 VAL A CG2 1 ? 
ATOM   848  N N   . GLU A 1 111 ? -15.019 4.220   11.326 1.000 48.227  0 111 GLU A N   1 ? 
ATOM   849  C CA  . GLU A 1 111 ? -16.289 3.869   10.696 1.000 49.078  0 111 GLU A CA  1 ? 
ATOM   850  C C   . GLU A 1 111 ? -16.575 2.384   10.935 1.000 39.165  0 111 GLU A C   1 ? 
ATOM   851  O O   . GLU A 1 111 ? -17.683 2.011   11.301 1.000 35.001  0 111 GLU A O   1 ? 
ATOM   852  C CB  . GLU A 1 111 ? -16.274 4.182   9.187  1.000 59.070  0 111 GLU A CB  1 ? 
ATOM   853  C CG  . GLU A 1 111 ? -16.354 5.674   8.827  1.000 61.314  0 111 GLU A CG  1 ? 
ATOM   854  C CD  . GLU A 1 111 ? -16.353 6.074   7.347  1.000 58.291  0 111 GLU A CD  1 ? 
ATOM   855  O OE1 . GLU A 1 111 ? -16.488 5.198   6.441  1.000 52.368  0 111 GLU A OE1 1 ? 
ATOM   856  O OE2 . GLU A 1 111 ? -16.205 7.288   7.091  1.000 53.615  0 111 GLU A OE2 1 ? 
ATOM   857  N N   . LEU A 1 112 ? -15.561 1.542   10.736 1.000 36.092  0 112 LEU A N   1 ? 
ATOM   858  C CA  . LEU A 1 112 ? -15.696 0.111   10.947 1.000 36.849  0 112 LEU A CA  1 ? 
ATOM   859  C C   . LEU A 1 112 ? -16.051 -0.153  12.394 1.000 40.061  0 112 LEU A C   1 ? 
ATOM   860  O O   . LEU A 1 112 ? -16.849 -1.047  12.655 1.000 39.142  0 112 LEU A O   1 ? 
ATOM   861  C CB  . LEU A 1 112 ? -14.385 -0.595  10.624 1.000 39.326  0 112 LEU A CB  1 ? 
ATOM   862  C CG  . LEU A 1 112 ? -14.200 -1.010  9.171  1.000 37.792  0 112 LEU A CG  1 ? 
ATOM   863  C CD1 . LEU A 1 112 ? -14.312 0.179   8.249  1.000 40.962  0 112 LEU A CD1 1 ? 
ATOM   864  C CD2 . LEU A 1 112 ? -12.856 -1.650  9.024  1.000 38.611  0 112 LEU A CD2 1 ? 
ATOM   865  N N   . GLU A 1 113 ? -15.474 0.667   13.288 1.000 40.491  0 113 GLU A N   1 ? 
ATOM   866  C CA  . GLU A 1 113 ? -15.477 0.408   14.718 1.000 40.675  0 113 GLU A CA  1 ? 
ATOM   867  C C   . GLU A 1 113 ? -16.784 0.863   15.358 1.000 37.999  0 113 GLU A C   1 ? 
ATOM   868  O O   . GLU A 1 113 ? -16.911 0.800   16.580 1.000 34.382  0 113 GLU A O   1 ? 
ATOM   869  C CB  . GLU A 1 113 ? -14.292 1.099   15.393 1.000 44.323  0 113 GLU A CB  1 ? 
ATOM   870  C CG  . GLU A 1 113 ? -12.973 0.343   15.306 1.000 47.962  0 113 GLU A CG  1 ? 
ATOM   871  C CD  . GLU A 1 113 ? -11.759 1.193   15.675 1.000 51.744  0 113 GLU A CD  1 ? 
ATOM   872  O OE1 . GLU A 1 113 ? -11.926 2.415   15.769 1.000 49.331  0 113 GLU A OE1 1 ? 
ATOM   873  O OE2 . GLU A 1 113 ? -10.630 0.644   15.864 1.000 54.358  0 113 GLU A OE2 1 ? 
ATOM   874  N N   . LYS A 1 114 ? -17.748 1.294   14.542 1.000 40.695  0 114 LYS A N   1 ? 
ATOM   875  C CA  . LYS A 1 114 ? -19.118 1.468   15.016 1.000 46.935  0 114 LYS A CA  1 ? 
ATOM   876  C C   . LYS A 1 114 ? -19.783 0.101   15.206 1.000 44.377  0 114 LYS A C   1 ? 
ATOM   877  O O   . LYS A 1 114 ? -20.612 -0.083  16.092 1.000 54.551  0 114 LYS A O   1 ? 
ATOM   878  C CB  . LYS A 1 114 ? -19.934 2.306   14.028 1.000 44.825  0 114 LYS A CB  1 ? 
ATOM   879  C CG  . LYS A 1 114 ? -19.373 3.679   13.719 1.000 44.817  0 114 LYS A CG  1 ? 
ATOM   880  C CD  . LYS A 1 114 ? -19.288 4.565   14.936 1.000 53.491  0 114 LYS A CD  1 ? 
ATOM   881  C CE  . LYS A 1 114 ? -18.737 5.939   14.615 1.000 55.370  0 114 LYS A CE  1 ? 
ATOM   882  N NZ  . LYS A 1 114 ? -19.085 6.885   15.696 1.000 58.451  0 114 LYS A NZ  1 ? 
ATOM   883  N N   . SER A 1 115 ? -19.416 -0.854  14.356 1.000 41.458  0 115 SER A N   1 ? 
ATOM   884  C CA  . SER A 1 115 ? -19.958 -2.193  14.441 1.000 39.742  0 115 SER A CA  1 ? 
ATOM   885  C C   . SER A 1 115 ? -19.396 -2.895  15.677 1.000 45.065  0 115 SER A C   1 ? 
ATOM   886  O O   . SER A 1 115 ? -18.179 -3.045  15.838 1.000 49.554  0 115 SER A O   1 ? 
ATOM   887  C CB  . SER A 1 115 ? -19.661 -2.971  13.198 1.000 39.571  0 115 SER A CB  1 ? 
ATOM   888  O OG  . SER A 1 115 ? -19.827 -4.355  13.429 1.000 35.478  0 115 SER A OG  1 ? 
ATOM   889  N N   . SER A 1 116 ? -20.317 -3.300  16.548 1.000 42.135  0 116 SER A N   1 ? 
ATOM   890  C CA  . SER A 1 116 ? -20.027 -4.150  17.680 1.000 45.518  0 116 SER A CA  1 ? 
ATOM   891  C C   . SER A 1 116 ? -19.435 -5.489  17.211 1.000 46.407  0 116 SER A C   1 ? 
ATOM   892  O O   . SER A 1 116 ? -18.455 -5.965  17.792 1.000 41.913  0 116 SER A O   1 ? 
ATOM   893  C CB  . SER A 1 116 ? -21.303 -4.321  18.471 1.000 50.428  0 116 SER A CB  1 ? 
ATOM   894  O OG  . SER A 1 116 ? -21.039 -4.728  19.796 1.000 53.949  0 116 SER A OG  1 ? 
ATOM   895  N N   . LYS A 1 117 ? -20.012 -6.078  16.144 1.000 39.771  0 117 LYS A N   1 ? 
ATOM   896  C CA  . LYS A 1 117 ? -19.534 -7.344  15.612 1.000 39.232  0 117 LYS A CA  1 ? 
ATOM   897  C C   . LYS A 1 117 ? -18.090 -7.201  15.146 1.000 40.816  0 117 LYS A C   1 ? 
ATOM   898  O O   . LYS A 1 117 ? -17.261 -8.081  15.364 1.000 52.615  0 117 LYS A O   1 ? 
ATOM   899  C CB  . LYS A 1 117 ? -20.435 -7.800  14.465 1.000 43.471  0 117 LYS A CB  1 ? 
ATOM   900  C CG  . LYS A 1 117 ? -20.002 -9.080  13.764 1.000 41.476  0 117 LYS A CG  1 ? 
ATOM   901  C CD  . LYS A 1 117 ? -21.091 -9.721  12.938 1.000 39.158  0 117 LYS A CD  1 ? 
ATOM   902  C CE  . LYS A 1 117 ? -20.714 -11.120 12.502 1.000 44.519  0 117 LYS A CE  1 ? 
ATOM   903  N NZ  . LYS A 1 117 ? -21.847 -11.853 11.879 1.000 44.884  0 117 LYS A NZ  1 ? 
ATOM   904  N N   . PHE A 1 118 ? -17.775 -6.067  14.520 1.000 40.318  0 118 PHE A N   1 ? 
ATOM   905  C CA  . PHE A 1 118 ? -16.439 -5.817  14.020 1.000 36.771  0 118 PHE A CA  1 ? 
ATOM   906  C C   . PHE A 1 118 ? -15.441 -5.831  15.160 1.000 36.773  0 118 PHE A C   1 ? 
ATOM   907  O O   . PHE A 1 118 ? -14.433 -6.528  15.090 1.000 32.869  0 118 PHE A O   1 ? 
ATOM   908  C CB  . PHE A 1 118 ? -16.361 -4.453  13.361 1.000 36.083  0 118 PHE A CB  1 ? 
ATOM   909  C CG  . PHE A 1 118 ? -14.966 -4.097  12.951 1.000 36.199  0 118 PHE A CG  1 ? 
ATOM   910  C CD1 . PHE A 1 118 ? -14.384 -4.688  11.848 1.000 40.021  0 118 PHE A CD1 1 ? 
ATOM   911  C CD2 . PHE A 1 118 ? -14.227 -3.181  13.677 1.000 43.011  0 118 PHE A CD2 1 ? 
ATOM   912  C CE1 . PHE A 1 118 ? -13.083 -4.367  11.474 1.000 41.106  0 118 PHE A CE1 1 ? 
ATOM   913  C CE2 . PHE A 1 118 ? -12.933 -2.846  13.292 1.000 38.888  0 118 PHE A CE2 1 ? 
ATOM   914  C CZ  . PHE A 1 118 ? -12.365 -3.443  12.195 1.000 37.698  0 118 PHE A CZ  1 ? 
ATOM   915  N N   . ASN A 1 119 ? -15.768 -5.066  16.211 1.000 41.269  0 119 ASN A N   1 ? 
ATOM   916  C CA  . ASN A 1 119 ? -14.933 -4.985  17.398 1.000 40.160  0 119 ASN A CA  1 ? 
ATOM   917  C C   . ASN A 1 119 ? -14.677 -6.371  17.998 1.000 39.294  0 119 ASN A C   1 ? 
ATOM   918  O O   . ASN A 1 119 ? -13.563 -6.662  18.429 1.000 43.156  0 119 ASN A O   1 ? 
ATOM   919  C CB  . ASN A 1 119 ? -15.486 -3.983  18.406 1.000 38.694  0 119 ASN A CB  1 ? 
ATOM   920  C CG  . ASN A 1 119 ? -15.216 -2.545  18.005 1.000 40.106  0 119 ASN A CG  1 ? 
ATOM   921  O OD1 . ASN A 1 119 ? -14.086 -2.177  17.692 1.000 49.731  0 119 ASN A OD1 1 ? 
ATOM   922  N ND2 . ASN A 1 119 ? -16.246 -1.717  17.992 1.000 39.507  0 119 ASN A ND2 1 ? 
ATOM   923  N N   . ASP A 1 120 ? -15.670 -7.249  17.991 1.000 35.646  0 120 ASP A N   1 ? 
ATOM   924  C CA  . ASP A 1 120 ? -15.491 -8.580  18.559 1.000 42.575  0 120 ASP A CA  1 ? 
ATOM   925  C C   . ASP A 1 120 ? -14.505 -9.403  17.731 1.000 40.383  0 120 ASP A C   1 ? 
ATOM   926  O O   . ASP A 1 120 ? -13.796 -10.257 18.260 1.000 35.689  0 120 ASP A O   1 ? 
ATOM   927  C CB  . ASP A 1 120 ? -16.818 -9.341  18.631 1.000 45.182  0 120 ASP A CB  1 ? 
ATOM   928  C CG  . ASP A 1 120 ? -17.850 -8.648  19.500 1.000 53.584  0 120 ASP A CG  1 ? 
ATOM   929  O OD1 . ASP A 1 120 ? -17.493 -8.234  20.641 1.000 54.975  0 120 ASP A OD1 1 ? 
ATOM   930  O OD2 . ASP A 1 120 ? -19.007 -8.544  19.041 1.000 65.822  0 120 ASP A OD2 1 ? 
ATOM   931  N N   . ILE A 1 121 ? -14.523 -9.191  16.413 1.000 37.471  0 121 ILE A N   1 ? 
ATOM   932  C CA  . ILE A 1 121 ? -13.674 -9.961  15.528 1.000 36.047  0 121 ILE A CA  1 ? 
ATOM   933  C C   . ILE A 1 121 ? -12.245 -9.562  15.834 1.000 33.732  0 121 ILE A C   1 ? 
ATOM   934  O O   . ILE A 1 121 ? -11.387 -10.411 16.051 1.000 34.719  0 121 ILE A O   1 ? 
ATOM   935  C CB  . ILE A 1 121 ? -14.090 -9.728  14.063 1.000 38.512  0 121 ILE A CB  1 ? 
ATOM   936  C CG1 . ILE A 1 121 ? -15.500 -10.251 13.803 1.000 43.441  0 121 ILE A CG1 1 ? 
ATOM   937  C CG2 . ILE A 1 121 ? -13.119 -10.339 13.077 1.000 39.118  0 121 ILE A CG2 1 ? 
ATOM   938  C CD1 . ILE A 1 121 ? -15.993 -9.947  12.399 1.000 48.381  0 121 ILE A CD1 1 ? 
ATOM   939  N N   . LEU A 1 122 ? -12.055 -8.249  15.929 1.000 34.756  0 122 LEU A N   1 ? 
ATOM   940  C CA  . LEU A 1 122 ? -10.760 -7.639  16.181 1.000 38.521  0 122 LEU A CA  1 ? 
ATOM   941  C C   . LEU A 1 122 ? -10.220 -8.140  17.526 1.000 35.256  0 122 LEU A C   1 ? 
ATOM   942  O O   . LEU A 1 122 ? -9.057  -8.525  17.621 1.000 36.264  0 122 LEU A O   1 ? 
ATOM   943  C CB  . LEU A 1 122 ? -10.950 -6.111  16.154 1.000 42.522  0 122 LEU A CB  1 ? 
ATOM   944  C CG  . LEU A 1 122 ? -9.947  -5.293  15.335 1.000 48.283  0 122 LEU A CG  1 ? 
ATOM   945  C CD1 . LEU A 1 122 ? -10.002 -5.644  13.853 1.000 50.318  0 122 LEU A CD1 1 ? 
ATOM   946  C CD2 . LEU A 1 122 ? -10.183 -3.791  15.518 1.000 48.604  0 122 LEU A CD2 1 ? 
ATOM   947  N N   . ASP A 1 123 ? -11.066 -8.135  18.570 1.000 34.575  0 123 ASP A N   1 ? 
ATOM   948  C CA  . ASP A 1 123 ? -10.683 -8.619  19.882 1.000 30.350  0 123 ASP A CA  1 ? 
ATOM   949  C C   . ASP A 1 123 ? -10.388 -10.117 19.792 1.000 31.617  0 123 ASP A C   1 ? 
ATOM   950  O O   . ASP A 1 123 ? -9.408  -10.589 20.354 1.000 35.036  0 123 ASP A O   1 ? 
ATOM   951  C CB  . ASP A 1 123 ? -11.770 -8.285  20.896 1.000 37.311  0 123 ASP A CB  1 ? 
ATOM   952  N N   . LEU A 1 124 ? -11.144 -10.857 18.982 1.000 29.793  0 124 LEU A N   1 ? 
ATOM   953  C CA  . LEU A 1 124 ? -10.842 -12.263 18.769 1.000 32.457  0 124 LEU A CA  1 ? 
ATOM   954  C C   . LEU A 1 124 ? -9.463  -12.444 18.123 1.000 36.089  0 124 LEU A C   1 ? 
ATOM   955  O O   . LEU A 1 124 ? -8.665  -13.250 18.603 1.000 39.970  0 124 LEU A O   1 ? 
ATOM   956  C CB  . LEU A 1 124 ? -11.943 -12.913 17.929 1.000 34.190  0 124 LEU A CB  1 ? 
ATOM   957  N N   . LEU A 1 125 ? -9.157  -11.698 17.052 1.000 36.644  0 125 LEU A N   1 ? 
ATOM   958  C CA  . LEU A 1 125 ? -7.883  -11.835 16.355 1.000 33.697  0 125 LEU A CA  1 ? 
ATOM   959  C C   . LEU A 1 125 ? -6.711  -11.527 17.285 1.000 30.393  0 125 LEU A C   1 ? 
ATOM   960  O O   . LEU A 1 125 ? -5.655  -12.148 17.207 1.000 33.409  0 125 LEU A O   1 ? 
ATOM   961  C CB  . LEU A 1 125 ? -7.869  -10.883 15.152 1.000 39.077  0 125 LEU A CB  1 ? 
ATOM   962  C CG  . LEU A 1 125 ? -8.685  -11.304 13.927 1.000 42.739  0 125 LEU A CG  1 ? 
ATOM   963  C CD1 . LEU A 1 125 ? -8.630  -10.231 12.837 1.000 40.429  0 125 LEU A CD1 1 ? 
ATOM   964  C CD2 . LEU A 1 125 ? -8.193  -12.644 13.369 1.000 39.120  0 125 LEU A CD2 1 ? 
ATOM   965  N N   . ARG A 1 126 ? -6.904  -10.524 18.132 1.000 30.912  0 126 ARG A N   1 ? 
ATOM   966  C CA  . ARG A 1 126 ? -5.904  -10.090 19.086 1.000 34.120  0 126 ARG A CA  1 ? 
ATOM   967  C C   . ARG A 1 126 ? -5.591  -11.190 20.096 1.000 36.627  0 126 ARG A C   1 ? 
ATOM   968  O O   . ARG A 1 126 ? -4.429  -11.425 20.438 1.000 38.269  0 126 ARG A O   1 ? 
ATOM   969  C CB  . ARG A 1 126 ? -6.449  -8.884  19.846 1.000 33.984  0 126 ARG A CB  1 ? 
ATOM   970  C CG  . ARG A 1 126 ? -5.407  -8.271  20.756 1.000 37.812  0 126 ARG A CG  1 ? 
ATOM   971  C CD  . ARG A 1 126 ? -5.956  -7.014  21.372 1.000 43.044  0 126 ARG A CD  1 ? 
ATOM   972  N NE  . ARG A 1 126 ? -5.059  -6.463  22.365 1.000 47.249  0 126 ARG A NE  1 ? 
ATOM   973  C CZ  . ARG A 1 126 ? -5.354  -5.398  23.087 1.000 51.687  0 126 ARG A CZ  1 ? 
ATOM   974  N NH1 . ARG A 1 126 ? -6.617  -5.006  23.154 1.000 49.115  0 126 ARG A NH1 1 ? 
ATOM   975  N NH2 . ARG A 1 126 ? -4.399  -4.757  23.747 1.000 54.620  0 126 ARG A NH2 1 ? 
ATOM   976  N N   . SER A 1 127 ? -6.640  -11.857 20.589 1.000 39.308  0 127 SER A N   1 ? 
ATOM   977  C CA  . SER A 1 127 ? -6.491  -12.975 21.509 1.000 40.426  0 127 SER A CA  1 ? 
ATOM   978  C C   . SER A 1 127 ? -5.499  -13.991 20.943 1.000 39.824  0 127 SER A C   1 ? 
ATOM   979  O O   . SER A 1 127 ? -4.814  -14.658 21.704 1.000 45.296  0 127 SER A O   1 ? 
ATOM   980  C CB  . SER A 1 127 ? -7.814  -13.622 21.791 1.000 42.405  0 127 SER A CB  1 ? 
ATOM   981  O OG  . SER A 1 127 ? -8.183  -14.486 20.714 1.000 51.626  0 127 SER A OG  1 ? 
ATOM   982  N N   . HIS A 1 128 ? -5.384  -14.054 19.612 1.000 41.965  0 128 HIS A N   1 ? 
ATOM   983  C CA  . HIS A 1 128 ? -4.504  -15.005 18.956 1.000 43.526  0 128 HIS A CA  1 ? 
ATOM   984  C C   . HIS A 1 128 ? -3.206  -14.377 18.489 1.000 42.885  0 128 HIS A C   1 ? 
ATOM   985  O O   . HIS A 1 128 ? -2.368  -15.081 17.943 1.000 43.901  0 128 HIS A O   1 ? 
ATOM   986  C CB  . HIS A 1 128 ? -5.115  -15.540 17.668 1.000 48.239  0 128 HIS A CB  1 ? 
ATOM   987  C CG  . HIS A 1 128 ? -6.386  -16.244 17.907 1.000 53.745  0 128 HIS A CG  1 ? 
ATOM   988  N ND1 . HIS A 1 128 ? -7.499  -16.148 17.108 1.000 62.045  0 128 HIS A ND1 1 ? 
ATOM   989  C CD2 . HIS A 1 128 ? -6.673  -17.079 18.872 1.000 63.065  0 128 HIS A CD2 1 ? 
ATOM   990  C CE1 . HIS A 1 128 ? -8.443  -16.909 17.610 1.000 61.314  0 128 HIS A CE1 1 ? 
ATOM   991  N NE2 . HIS A 1 128 ? -7.959  -17.490 18.680 1.000 70.978  0 128 HIS A NE2 1 ? 
ATOM   992  N N   . LEU A 1 129 ? -3.067  -13.058 18.643 1.000 43.966  0 129 LEU A N   1 ? 
ATOM   993  C CA  . LEU A 1 129 ? -1.759  -12.433 18.504 1.000 45.545  0 129 LEU A CA  1 ? 
ATOM   994  C C   . LEU A 1 129 ? -0.843  -13.032 19.579 1.000 49.117  0 129 LEU A C   1 ? 
ATOM   995  O O   . LEU A 1 129 ? -1.248  -13.188 20.736 1.000 56.024  0 129 LEU A O   1 ? 
ATOM   996  C CB  . LEU A 1 129 ? -1.893  -10.911 18.656 1.000 45.592  0 129 LEU A CB  1 ? 
ATOM   997  C CG  . LEU A 1 129 ? -2.211  -10.078 17.410 1.000 44.426  0 129 LEU A CG  1 ? 
ATOM   998  C CD1 . LEU A 1 129 ? -0.958  -9.464  16.863 1.000 53.382  0 129 LEU A CD1 1 ? 
ATOM   999  C CD2 . LEU A 1 129 ? -2.874  -10.891 16.302 1.000 46.876  0 129 LEU A CD2 1 ? 
ATOM   1000 N N   . PRO A 1 130 ? 0.391   -13.455 19.217 1.000 51.329  0 130 PRO A N   1 ? 
ATOM   1001 C CA  . PRO A 1 130 ? 1.313   -14.096 20.155 1.000 54.170  0 130 PRO A CA  1 ? 
ATOM   1002 C C   . PRO A 1 130 ? 1.862   -13.183 21.245 1.000 60.183  0 130 PRO A C   1 ? 
ATOM   1003 O O   . PRO A 1 130 ? 1.943   -11.971 21.058 1.000 56.942  0 130 PRO A O   1 ? 
ATOM   1004 C CB  . PRO A 1 130 ? 2.493   -14.509 19.254 1.000 52.122  0 130 PRO A CB  1 ? 
ATOM   1005 C CG  . PRO A 1 130 ? 2.447   -13.525 18.103 1.000 45.119  0 130 PRO A CG  1 ? 
ATOM   1006 C CD  . PRO A 1 130 ? 0.967   -13.361 17.866 1.000 46.817  0 130 PRO A CD  1 ? 
ATOM   1007 N N   . GLY A 1 131 ? 2.234   -13.783 22.385 1.000 72.230  0 131 GLY A N   1 ? 
ATOM   1008 C CA  . GLY A 1 131 ? 3.038   -13.101 23.388 1.000 81.507  0 131 GLY A CA  1 ? 
ATOM   1009 C C   . GLY A 1 131 ? 2.239   -12.136 24.263 1.000 91.634  0 131 GLY A C   1 ? 
ATOM   1010 O O   . GLY A 1 131 ? 1.195   -11.608 23.868 1.000 113.576 0 131 GLY A O   1 ? 
ATOM   1011 N N   . ASP A 1 132 ? 2.801   -11.874 25.447 1.000 97.926  0 132 ASP A N   1 ? 
ATOM   1012 C CA  . ASP A 1 132 ? 2.193   -10.997 26.433 1.000 99.405  0 132 ASP A CA  1 ? 
ATOM   1013 C C   . ASP A 1 132 ? 1.622   -9.754  25.759 1.000 97.120  0 132 ASP A C   1 ? 
ATOM   1014 O O   . ASP A 1 132 ? 0.431   -9.479  25.904 1.000 101.059 0 132 ASP A O   1 ? 
ATOM   1015 C CB  . ASP A 1 132 ? 3.207   -10.594 27.503 1.000 100.489 0 132 ASP A CB  1 ? 
ATOM   1016 N N   . ASN A 1 133 ? 2.481   -9.026  25.022 1.000 96.680  0 133 ASN A N   1 ? 
ATOM   1017 C CA  . ASN A 1 133 ? 2.098   -7.776  24.375 1.000 88.985  0 133 ASN A CA  1 ? 
ATOM   1018 C C   . ASN A 1 133 ? 1.411   -8.073  23.040 1.000 81.366  0 133 ASN A C   1 ? 
ATOM   1019 O O   . ASN A 1 133 ? 1.914   -7.735  21.970 1.000 80.380  0 133 ASN A O   1 ? 
ATOM   1020 C CB  . ASN A 1 133 ? 3.287   -6.820  24.203 1.000 77.653  0 133 ASN A CB  1 ? 
ATOM   1021 N N   . GLN A 1 134 ? 0.217   -8.668  23.113 1.000 73.059  0 134 GLN A N   1 ? 
ATOM   1022 C CA  . GLN A 1 134 ? -0.695  -8.719  21.978 1.000 61.065  0 134 GLN A CA  1 ? 
ATOM   1023 C C   . GLN A 1 134 ? -1.461  -7.390  21.890 1.000 53.825  0 134 GLN A C   1 ? 
ATOM   1024 O O   . GLN A 1 134 ? -2.453  -7.173  22.586 1.000 54.039  0 134 GLN A O   1 ? 
ATOM   1025 C CB  . GLN A 1 134 ? -1.588  -9.962  22.054 1.000 56.564  0 134 GLN A CB  1 ? 
ATOM   1026 C CG  . GLN A 1 134 ? -2.082  -10.350 23.447 1.000 57.536  0 134 GLN A CG  1 ? 
ATOM   1027 C CD  . GLN A 1 134 ? -2.508  -11.797 23.477 1.000 52.544  0 134 GLN A CD  1 ? 
ATOM   1028 O OE1 . GLN A 1 134 ? -3.657  -12.125 23.745 1.000 56.223  0 134 GLN A OE1 1 ? 
ATOM   1029 N NE2 . GLN A 1 134 ? -1.575  -12.679 23.171 1.000 50.677  0 134 GLN A NE2 1 ? 
ATOM   1030 N N   . LEU A 1 135 ? -0.969  -6.495  21.024 1.000 50.896  0 135 LEU A N   1 ? 
ATOM   1031 C CA  . LEU A 1 135 ? -1.458  -5.126  20.947 1.000 48.121  0 135 LEU A CA  1 ? 
ATOM   1032 C C   . LEU A 1 135 ? -2.696  -5.054  20.053 1.000 44.874  0 135 LEU A C   1 ? 
ATOM   1033 O O   . LEU A 1 135 ? -2.935  -5.914  19.208 1.000 42.102  0 135 LEU A O   1 ? 
ATOM   1034 C CB  . LEU A 1 135 ? -0.356  -4.225  20.377 1.000 47.124  0 135 LEU A CB  1 ? 
ATOM   1035 C CG  . LEU A 1 135 ? 0.973   -4.220  21.132 1.000 50.209  0 135 LEU A CG  1 ? 
ATOM   1036 C CD1 . LEU A 1 135 ? 2.076   -3.584  20.288 1.000 52.166  0 135 LEU A CD1 1 ? 
ATOM   1037 C CD2 . LEU A 1 135 ? 0.837   -3.489  22.449 1.000 44.394  0 135 LEU A CD2 1 ? 
ATOM   1038 N N   . ASP A 1 136 ? -3.470  -3.984  20.255 1.000 43.237  0 136 ASP A N   1 ? 
ATOM   1039 C CA  . ASP A 1 136 ? -4.573  -3.627  19.381 1.000 44.998  0 136 ASP A CA  1 ? 
ATOM   1040 C C   . ASP A 1 136 ? -4.032  -3.146  18.028 1.000 42.653  0 136 ASP A C   1 ? 
ATOM   1041 O O   . ASP A 1 136 ? -2.834  -2.930  17.849 1.000 38.472  0 136 ASP A O   1 ? 
ATOM   1042 C CB  . ASP A 1 136 ? -5.434  -2.548  20.038 1.000 46.397  0 136 ASP A CB  1 ? 
ATOM   1043 C CG  . ASP A 1 136 ? -4.618  -1.370  20.537 1.000 56.151  0 136 ASP A CG  1 ? 
ATOM   1044 O OD1 . ASP A 1 136 ? -3.984  -1.513  21.619 1.000 75.939  0 136 ASP A OD1 1 ? 
ATOM   1045 O OD2 . ASP A 1 136 ? -4.586  -0.337  19.843 1.000 64.203  0 136 ASP A OD2 1 ? 
ATOM   1046 N N   . LEU A 1 137 ? -4.952  -2.969  17.080 1.000 40.872  0 137 LEU A N   1 ? 
ATOM   1047 C CA  . LEU A 1 137 ? -4.630  -2.599  15.717 1.000 38.635  0 137 LEU A CA  1 ? 
ATOM   1048 C C   . LEU A 1 137 ? -3.906  -1.253  15.682 1.000 36.815  0 137 LEU A C   1 ? 
ATOM   1049 O O   . LEU A 1 137 ? -2.780  -1.179  15.202 1.000 36.449  0 137 LEU A O   1 ? 
ATOM   1050 C CB  . LEU A 1 137 ? -5.939  -2.567  14.924 1.000 36.948  0 137 LEU A CB  1 ? 
ATOM   1051 C CG  . LEU A 1 137 ? -5.822  -2.610  13.404 1.000 36.195  0 137 LEU A CG  1 ? 
ATOM   1052 C CD1 . LEU A 1 137 ? -4.661  -3.506  12.939 1.000 33.774  0 137 LEU A CD1 1 ? 
ATOM   1053 C CD2 . LEU A 1 137 ? -7.146  -3.079  12.808 1.000 38.331  0 137 LEU A CD2 1 ? 
ATOM   1054 N N   . ARG A 1 138 ? -4.506  -0.198  16.234 1.000 39.232  0 138 ARG A N   1 ? 
ATOM   1055 C CA  . ARG A 1 138 ? -3.925  1.126   16.048 1.000 43.247  0 138 ARG A CA  1 ? 
ATOM   1056 C C   . ARG A 1 138 ? -2.514  1.130   16.621 1.000 36.590  0 138 ARG A C   1 ? 
ATOM   1057 O O   . ARG A 1 138 ? -1.636  1.820   16.108 1.000 33.117  0 138 ARG A O   1 ? 
ATOM   1058 C CB  . ARG A 1 138 ? -4.786  2.293   16.559 1.000 51.524  0 138 ARG A CB  1 ? 
ATOM   1059 C CG  . ARG A 1 138 ? -5.665  2.058   17.786 1.000 61.660  0 138 ARG A CG  1 ? 
ATOM   1060 C CD  . ARG A 1 138 ? -7.124  1.821   17.445 1.000 66.660  0 138 ARG A CD  1 ? 
ATOM   1061 N NE  . ARG A 1 138 ? -7.641  2.908   16.620 1.000 69.581  0 138 ARG A NE  1 ? 
ATOM   1062 C CZ  . ARG A 1 138 ? -8.881  3.381   16.650 1.000 67.668  0 138 ARG A CZ  1 ? 
ATOM   1063 N NH1 . ARG A 1 138 ? -9.710  3.061   17.622 1.000 69.740  0 138 ARG A NH1 1 ? 
ATOM   1064 N NH2 . ARG A 1 138 ? -9.292  4.193   15.696 1.000 67.481  0 138 ARG A NH2 1 ? 
ATOM   1065 N N   . SER A 1 139 ? -2.281  0.315   17.645 1.000 34.083  0 139 SER A N   1 ? 
ATOM   1066 C CA  . SER A 1 139 ? -0.953  0.243   18.231 1.000 35.149  0 139 SER A CA  1 ? 
ATOM   1067 C C   . SER A 1 139 ? 0.060   -0.365  17.244 1.000 31.633  0 139 SER A C   1 ? 
ATOM   1068 O O   . SER A 1 139 ? 1.259   -0.151  17.390 1.000 32.987  0 139 SER A O   1 ? 
ATOM   1069 C CB  . SER A 1 139 ? -1.014  -0.473  19.560 1.000 37.654  0 139 SER A CB  1 ? 
ATOM   1070 O OG  . SER A 1 139 ? 0.211   -1.146  19.861 1.000 49.550  0 139 SER A OG  1 ? 
ATOM   1071 N N   . TYR A 1 140 ? -0.404  -1.089  16.212 1.000 30.119  0 140 TYR A N   1 ? 
ATOM   1072 C CA  . TYR A 1 140 ? 0.471   -1.542  15.140 1.000 31.121  0 140 TYR A CA  1 ? 
ATOM   1073 C C   . TYR A 1 140 ? 0.550   -0.494  14.027 1.000 28.820  0 140 TYR A C   1 ? 
ATOM   1074 O O   . TYR A 1 140 ? 1.630   -0.195  13.526 1.000 34.099  0 140 TYR A O   1 ? 
ATOM   1075 C CB  . TYR A 1 140 ? 0.037   -2.923  14.636 1.000 31.577  0 140 TYR A CB  1 ? 
ATOM   1076 C CG  . TYR A 1 140 ? 0.311   -4.037  15.615 1.000 34.853  0 140 TYR A CG  1 ? 
ATOM   1077 C CD1 . TYR A 1 140 ? 1.609   -4.366  15.951 1.000 43.364  0 140 TYR A CD1 1 ? 
ATOM   1078 C CD2 . TYR A 1 140 ? -0.698  -4.753  16.221 1.000 36.942  0 140 TYR A CD2 1 ? 
ATOM   1079 C CE1 . TYR A 1 140 ? 1.900   -5.367  16.859 1.000 40.573  0 140 TYR A CE1 1 ? 
ATOM   1080 C CE2 . TYR A 1 140 ? -0.431  -5.758  17.138 1.000 39.828  0 140 TYR A CE2 1 ? 
ATOM   1081 C CZ  . TYR A 1 140 ? 0.878   -6.063  17.464 1.000 42.700  0 140 TYR A CZ  1 ? 
ATOM   1082 O OH  . TYR A 1 140 ? 1.233   -7.053  18.350 1.000 44.598  0 140 TYR A OH  1 ? 
ATOM   1083 N N   . LEU A 1 141 ? -0.592  0.057   13.627 1.000 31.530  0 141 LEU A N   1 ? 
ATOM   1084 C CA  . LEU A 1 141 ? -0.651  0.965   12.486 1.000 33.926  0 141 LEU A CA  1 ? 
ATOM   1085 C C   . LEU A 1 141 ? 0.166   2.228   12.737 1.000 29.077  0 141 LEU A C   1 ? 
ATOM   1086 O O   . LEU A 1 141 ? 0.574   2.873   11.789 1.000 30.103  0 141 LEU A O   1 ? 
ATOM   1087 C CB  . LEU A 1 141 ? -2.106  1.345   12.162 1.000 34.449  0 141 LEU A CB  1 ? 
ATOM   1088 C CG  . LEU A 1 141 ? -2.918  0.377   11.285 1.000 36.479  0 141 LEU A CG  1 ? 
ATOM   1089 C CD1 . LEU A 1 141 ? -2.067  -0.618  10.517 1.000 38.026  0 141 LEU A CD1 1 ? 
ATOM   1090 C CD2 . LEU A 1 141 ? -3.947  -0.371  12.088 1.000 35.964  0 141 LEU A CD2 1 ? 
ATOM   1091 N N   . ILE A 1 142 ? 0.411   2.561   14.001 1.000 26.599  0 142 ILE A N   1 ? 
ATOM   1092 C CA  . ILE A 1 142 ? 1.050   3.813   14.358 1.000 26.567  0 142 ILE A CA  1 ? 
ATOM   1093 C C   . ILE A 1 142 ? 2.561   3.660   14.340 1.000 24.530  0 142 ILE A C   1 ? 
ATOM   1094 O O   . ILE A 1 142 ? 3.272   4.647   14.265 1.000 22.418  0 142 ILE A O   1 ? 
ATOM   1095 C CB  . ILE A 1 142 ? 0.525   4.274   15.729 1.000 31.830  0 142 ILE A CB  1 ? 
ATOM   1096 C CG1 . ILE A 1 142 ? 0.845   5.742   16.014 1.000 35.856  0 142 ILE A CG1 1 ? 
ATOM   1097 C CG2 . ILE A 1 142 ? 1.031   3.365   16.841 1.000 36.135  0 142 ILE A CG2 1 ? 
ATOM   1098 C CD1 . ILE A 1 142 ? 0.235   6.693   15.024 1.000 37.932  0 142 ILE A CD1 1 ? 
ATOM   1099 N N   . MET A 1 143 ? 3.051   2.420   14.358 1.000 29.311  0 143 MET A N   1 ? 
ATOM   1100 C CA  . MET A 1 143 ? 4.465   2.154   14.600 1.000 32.055  0 143 MET A CA  1 ? 
ATOM   1101 C C   . MET A 1 143 ? 5.369   2.759   13.529 1.000 36.181  0 143 MET A C   1 ? 
ATOM   1102 O O   . MET A 1 143 ? 6.455   3.260   13.845 1.000 35.123  0 143 MET A O   1 ? 
ATOM   1103 C CB  . MET A 1 143 ? 4.760   0.659   14.679 1.000 33.157  0 143 MET A CB  1 ? 
ATOM   1104 C CG  . MET A 1 143 ? 4.577   0.118   16.056 1.000 34.237  0 143 MET A CG  1 ? 
ATOM   1105 S SD  . MET A 1 143 ? 4.826   -1.658  16.088 1.000 35.531  0 143 MET A SD  1 ? 
ATOM   1106 C CE  . MET A 1 143 ? 5.715   -1.853  17.632 1.000 47.398  0 143 MET A CE  1 ? 
ATOM   1107 N N   . PRO A 1 144 ? 5.001   2.689   12.231 1.000 36.680  0 144 PRO A N   1 ? 
ATOM   1108 C CA  . PRO A 1 144 ? 5.785   3.373   11.210 1.000 36.842  0 144 PRO A CA  1 ? 
ATOM   1109 C C   . PRO A 1 144 ? 5.827   4.871   11.498 1.000 40.043  0 144 PRO A C   1 ? 
ATOM   1110 O O   . PRO A 1 144 ? 6.841   5.520   11.274 1.000 43.911  0 144 PRO A O   1 ? 
ATOM   1111 C CB  . PRO A 1 144 ? 5.044   3.030   9.921  1.000 33.543  0 144 PRO A CB  1 ? 
ATOM   1112 C CG  . PRO A 1 144 ? 4.367   1.731   10.253 1.000 33.373  0 144 PRO A CG  1 ? 
ATOM   1113 C CD  . PRO A 1 144 ? 3.866   1.946   11.668 1.000 34.617  0 144 PRO A CD  1 ? 
ATOM   1114 N N   . VAL A 1 145 ? 4.741   5.412   12.042 1.000 37.649  0 145 VAL A N   1 ? 
ATOM   1115 C CA  . VAL A 1 145 ? 4.677   6.844   12.276 1.000 40.714  0 145 VAL A CA  1 ? 
ATOM   1116 C C   . VAL A 1 145 ? 5.636   7.200   13.400 1.000 39.442  0 145 VAL A C   1 ? 
ATOM   1117 O O   . VAL A 1 145 ? 6.140   8.315   13.452 1.000 47.733  0 145 VAL A O   1 ? 
ATOM   1118 C CB  . VAL A 1 145 ? 3.253   7.319   12.625 1.000 46.512  0 145 VAL A CB  1 ? 
ATOM   1119 C CG1 . VAL A 1 145 ? 3.128   8.839   12.574 1.000 46.288  0 145 VAL A CG1 1 ? 
ATOM   1120 C CG2 . VAL A 1 145 ? 2.204   6.640   11.737 1.000 50.905  0 145 VAL A CG2 1 ? 
ATOM   1121 N N   . GLN A 1 146 ? 5.851   6.261   14.320 1.000 40.415  0 146 GLN A N   1 ? 
ATOM   1122 C CA  . GLN A 1 146 ? 6.711   6.512   15.463 1.000 38.179  0 146 GLN A CA  1 ? 
ATOM   1123 C C   . GLN A 1 146 ? 8.170   6.246   15.103 1.000 35.851  0 146 GLN A C   1 ? 
ATOM   1124 O O   . GLN A 1 146 ? 9.052   6.867   15.686 1.000 38.248  0 146 GLN A O   1 ? 
ATOM   1125 C CB  . GLN A 1 146 ? 6.333   5.667   16.681 1.000 39.283  0 146 GLN A CB  1 ? 
ATOM   1126 C CG  . GLN A 1 146 ? 5.114   6.188   17.422 1.000 41.872  0 146 GLN A CG  1 ? 
ATOM   1127 C CD  . GLN A 1 146 ? 4.565   5.153   18.388 1.000 53.268  0 146 GLN A CD  1 ? 
ATOM   1128 O OE1 . GLN A 1 146 ? 5.025   4.008   18.441 1.000 57.212  0 146 GLN A OE1 1 ? 
ATOM   1129 N NE2 . GLN A 1 146 ? 3.533   5.528   19.133 1.000 48.921  0 146 GLN A NE2 1 ? 
ATOM   1130 N N   . ARG A 1 147 ? 8.422   5.346   14.149 1.000 31.584  0 147 ARG A N   1 ? 
ATOM   1131 C CA  . ARG A 1 147 ? 9.781   4.945   13.830 1.000 30.789  0 147 ARG A CA  1 ? 
ATOM   1132 C C   . ARG A 1 147 ? 10.620  6.143   13.418 1.000 27.721  0 147 ARG A C   1 ? 
ATOM   1133 O O   . ARG A 1 147 ? 11.722  6.314   13.906 1.000 25.856  0 147 ARG A O   1 ? 
ATOM   1134 C CB  . ARG A 1 147 ? 9.858   3.932   12.678 1.000 33.990  0 147 ARG A CB  1 ? 
ATOM   1135 C CG  . ARG A 1 147 ? 11.202  3.218   12.614 1.000 34.151  0 147 ARG A CG  1 ? 
ATOM   1136 C CD  . ARG A 1 147 ? 11.474  2.400   13.863 1.000 36.902  0 147 ARG A CD  1 ? 
ATOM   1137 N NE  . ARG A 1 147 ? 12.814  1.817   13.866 1.000 41.262  0 147 ARG A NE  1 ? 
ATOM   1138 C CZ  . ARG A 1 147 ? 13.602  1.702   14.932 1.000 47.539  0 147 ARG A CZ  1 ? 
ATOM   1139 N NH1 . ARG A 1 147 ? 13.234  2.207   16.098 1.000 56.117  0 147 ARG A NH1 1 ? 
ATOM   1140 N NH2 . ARG A 1 147 ? 14.753  1.057   14.840 1.000 48.985  0 147 ARG A NH2 1 ? 
ATOM   1141 N N   . LEU A 1 148 ? 10.104  6.945   12.499 1.000 32.233  0 148 LEU A N   1 ? 
ATOM   1142 C CA  . LEU A 1 148 ? 10.882  8.032   11.908 1.000 39.238  0 148 LEU A CA  1 ? 
ATOM   1143 C C   . LEU A 1 148 ? 11.513  8.905   12.990 1.000 38.868  0 148 LEU A C   1 ? 
ATOM   1144 O O   . LEU A 1 148 ? 12.711  9.141   12.955 1.000 47.000  0 148 LEU A O   1 ? 
ATOM   1145 C CB  . LEU A 1 148 ? 10.003  8.879   10.978 1.000 38.219  0 148 LEU A CB  1 ? 
ATOM   1146 C CG  . LEU A 1 148 ? 9.915   8.429   9.523  1.000 39.276  0 148 LEU A CG  1 ? 
ATOM   1147 C CD1 . LEU A 1 148 ? 9.246   7.081   9.398  1.000 44.805  0 148 LEU A CD1 1 ? 
ATOM   1148 C CD2 . LEU A 1 148 ? 9.140   9.435   8.695  1.000 44.525  0 148 LEU A CD2 1 ? 
ATOM   1149 N N   . PRO A 1 149 ? 10.740  9.471   13.938 1.000 39.673  0 149 PRO A N   1 ? 
ATOM   1150 C CA  . PRO A 1 149 ? 11.331  10.300  14.976 1.000 38.110  0 149 PRO A CA  1 ? 
ATOM   1151 C C   . PRO A 1 149 ? 12.431  9.599   15.763 1.000 36.727  0 149 PRO A C   1 ? 
ATOM   1152 O O   . PRO A 1 149 ? 13.343  10.273  16.228 1.000 42.679  0 149 PRO A O   1 ? 
ATOM   1153 C CB  . PRO A 1 149 ? 10.166  10.664  15.921 1.000 43.225  0 149 PRO A CB  1 ? 
ATOM   1154 C CG  . PRO A 1 149 ? 8.894   10.119  15.286 1.000 41.043  0 149 PRO A CG  1 ? 
ATOM   1155 C CD  . PRO A 1 149 ? 9.268   9.433   13.997 1.000 39.455  0 149 PRO A CD  1 ? 
ATOM   1156 N N   . ARG A 1 150 ? 12.323  8.274   15.961 1.000 34.508  0 150 ARG A N   1 ? 
ATOM   1157 C CA  . ARG A 1 150 ? 13.311  7.536   16.734 1.000 31.659  0 150 ARG A CA  1 ? 
ATOM   1158 C C   . ARG A 1 150 ? 14.616  7.441   15.955 1.000 34.662  0 150 ARG A C   1 ? 
ATOM   1159 O O   . ARG A 1 150 ? 15.696  7.589   16.542 1.000 32.048  0 150 ARG A O   1 ? 
ATOM   1160 C CB  . ARG A 1 150 ? 12.907  6.097   17.045 1.000 37.394  0 150 ARG A CB  1 ? 
ATOM   1161 C CG  . ARG A 1 150 ? 12.190  5.891   18.366 1.000 46.181  0 150 ARG A CG  1 ? 
ATOM   1162 C CD  . ARG A 1 150 ? 12.918  6.353   19.627 1.000 53.853  0 150 ARG A CD  1 ? 
ATOM   1163 N NE  . ARG A 1 150 ? 13.771  5.387   20.315 1.000 51.903  0 150 ARG A NE  1 ? 
ATOM   1164 C CZ  . ARG A 1 150 ? 13.366  4.236   20.837 1.000 50.206  0 150 ARG A CZ  1 ? 
ATOM   1165 N NH1 . ARG A 1 150 ? 12.133  3.809   20.646 1.000 48.293  0 150 ARG A NH1 1 ? 
ATOM   1166 N NH2 . ARG A 1 150 ? 14.222  3.475   21.497 1.000 52.984  0 150 ARG A NH2 1 ? 
ATOM   1167 N N   . TYR A 1 151 ? 14.508  7.190   14.637 1.000 31.632  0 151 TYR A N   1 ? 
ATOM   1168 C CA  . TYR A 1 151 ? 15.674  7.234   13.770 1.000 31.974  0 151 TYR A CA  1 ? 
ATOM   1169 C C   . TYR A 1 151 ? 16.377  8.583   13.944 1.000 32.222  0 151 TYR A C   1 ? 
ATOM   1170 O O   . TYR A 1 151 ? 17.591  8.618   14.171 1.000 35.194  0 151 TYR A O   1 ? 
ATOM   1171 C CB  . TYR A 1 151 ? 15.327  7.006   12.296 1.000 31.424  0 151 TYR A CB  1 ? 
ATOM   1172 C CG  . TYR A 1 151 ? 14.946  5.603   11.879 1.000 35.767  0 151 TYR A CG  1 ? 
ATOM   1173 C CD1 . TYR A 1 151 ? 15.603  4.476   12.352 1.000 36.595  0 151 TYR A CD1 1 ? 
ATOM   1174 C CD2 . TYR A 1 151 ? 13.987  5.407   10.897 1.000 40.024  0 151 TYR A CD2 1 ? 
ATOM   1175 C CE1 . TYR A 1 151 ? 15.272  3.202   11.909 1.000 35.596  0 151 TYR A CE1 1 ? 
ATOM   1176 C CE2 . TYR A 1 151 ? 13.656  4.143   10.424 1.000 37.265  0 151 TYR A CE2 1 ? 
ATOM   1177 C CZ  . TYR A 1 151 ? 14.297  3.035   10.937 1.000 36.380  0 151 TYR A CZ  1 ? 
ATOM   1178 O OH  . TYR A 1 151 ? 13.883  1.800   10.485 1.000 33.306  0 151 TYR A OH  1 ? 
ATOM   1179 N N   . LYS A 1 152 ? 15.609  9.671   13.847 1.000 29.173  0 152 LYS A N   1 ? 
ATOM   1180 C CA  . LYS A 1 152 ? 16.149  11.014  13.950 1.000 33.334  0 152 LYS A CA  1 ? 
ATOM   1181 C C   . LYS A 1 152 ? 16.890  11.115  15.270 1.000 34.479  0 152 LYS A C   1 ? 
ATOM   1182 O O   . LYS A 1 152 ? 18.075  11.467  15.293 1.000 33.406  0 152 LYS A O   1 ? 
ATOM   1183 C CB  . LYS A 1 152 ? 15.045  12.076  13.868 1.000 39.652  0 152 LYS A CB  1 ? 
ATOM   1184 C CG  . LYS A 1 152 ? 15.478  13.533  14.039 1.000 45.357  0 152 LYS A CG  1 ? 
ATOM   1185 C CD  . LYS A 1 152 ? 14.550  14.554  13.357 1.000 47.594  0 152 LYS A CD  1 ? 
ATOM   1186 N N   . LEU A 1 153 ? 16.192  10.748  16.354 1.000 33.230  0 153 LEU A N   1 ? 
ATOM   1187 C CA  . LEU A 1 153 ? 16.790  10.802  17.675 1.000 33.060  0 153 LEU A CA  1 ? 
ATOM   1188 C C   . LEU A 1 153 ? 18.104  10.039  17.675 1.000 30.936  0 153 LEU A C   1 ? 
ATOM   1189 O O   . LEU A 1 153 ? 19.152  10.622  17.924 1.000 27.847  0 153 LEU A O   1 ? 
ATOM   1190 C CB  . LEU A 1 153 ? 15.840  10.205  18.712 1.000 37.159  0 153 LEU A CB  1 ? 
ATOM   1191 C CG  . LEU A 1 153 ? 14.859  11.197  19.331 1.000 41.911  0 153 LEU A CG  1 ? 
ATOM   1192 C CD1 . LEU A 1 153 ? 14.112  10.564  20.508 1.000 38.086  0 153 LEU A CD1 1 ? 
ATOM   1193 C CD2 . LEU A 1 153 ? 15.573  12.491  19.727 1.000 43.263  0 153 LEU A CD2 1 ? 
ATOM   1194 N N   . LEU A 1 154 ? 18.009  8.739   17.374 1.000 34.052  0 154 LEU A N   1 ? 
ATOM   1195 C CA  . LEU A 1 154 ? 19.120  7.810   17.478 1.000 34.056  0 154 LEU A CA  1 ? 
ATOM   1196 C C   . LEU A 1 154 ? 20.295  8.237   16.598 1.000 35.777  0 154 LEU A C   1 ? 
ATOM   1197 O O   . LEU A 1 154 ? 21.436  8.195   17.023 1.000 27.289  0 154 LEU A O   1 ? 
ATOM   1198 C CB  . LEU A 1 154 ? 18.597  6.438   17.070 1.000 40.073  0 154 LEU A CB  1 ? 
ATOM   1199 C CG  . LEU A 1 154 ? 17.557  5.834   18.018 1.000 45.084  0 154 LEU A CG  1 ? 
ATOM   1200 C CD1 . LEU A 1 154 ? 16.945  4.566   17.431 1.000 45.266  0 154 LEU A CD1 1 ? 
ATOM   1201 C CD2 . LEU A 1 154 ? 18.160  5.543   19.380 1.000 45.198  0 154 LEU A CD2 1 ? 
ATOM   1202 N N   . LEU A 1 155 ? 20.027  8.660   15.361 1.000 42.011  0 155 LEU A N   1 ? 
ATOM   1203 C CA  . LEU A 1 155 ? 21.093  9.066   14.459 1.000 40.855  0 155 LEU A CA  1 ? 
ATOM   1204 C C   . LEU A 1 155 ? 21.723  10.375  14.912 1.000 38.854  0 155 LEU A C   1 ? 
ATOM   1205 O O   . LEU A 1 155 ? 22.926  10.566  14.728 1.000 38.960  0 155 LEU A O   1 ? 
ATOM   1206 C CB  . LEU A 1 155 ? 20.533  9.213   13.044 1.000 47.226  0 155 LEU A CB  1 ? 
ATOM   1207 C CG  . LEU A 1 155 ? 20.791  8.051   12.095 1.000 46.873  0 155 LEU A CG  1 ? 
ATOM   1208 C CD1 . LEU A 1 155 ? 20.600  6.733   12.798 1.000 50.291  0 155 LEU A CD1 1 ? 
ATOM   1209 C CD2 . LEU A 1 155 ? 19.852  8.135   10.912 1.000 49.695  0 155 LEU A CD2 1 ? 
ATOM   1210 N N   . THR A 1 156 ? 20.920  11.289  15.460 1.000 38.349  0 156 THR A N   1 ? 
ATOM   1211 C CA  . THR A 1 156 ? 21.486  12.549  15.904 1.000 38.114  0 156 THR A CA  1 ? 
ATOM   1212 C C   . THR A 1 156 ? 22.511  12.240  16.990 1.000 36.823  0 156 THR A C   1 ? 
ATOM   1213 O O   . THR A 1 156 ? 23.655  12.664  16.910 1.000 43.069  0 156 THR A O   1 ? 
ATOM   1214 C CB  . THR A 1 156 ? 20.413  13.530  16.391 1.000 40.912  0 156 THR A CB  1 ? 
ATOM   1215 O OG1 . THR A 1 156 ? 19.467  13.840  15.363 1.000 42.040  0 156 THR A OG1 1 ? 
ATOM   1216 C CG2 . THR A 1 156 ? 21.039  14.815  16.879 1.000 41.734  0 156 THR A CG2 1 ? 
ATOM   1217 N N   . ASP A 1 157 ? 22.114  11.416  17.956 1.000 37.024  0 157 ASP A N   1 ? 
ATOM   1218 C CA  . ASP A 1 157 ? 22.969  11.076  19.084 1.000 41.310  0 157 ASP A CA  1 ? 
ATOM   1219 C C   . ASP A 1 157 ? 24.193  10.277  18.622 1.000 42.914  0 157 ASP A C   1 ? 
ATOM   1220 O O   . ASP A 1 157 ? 25.274  10.406  19.191 1.000 43.814  0 157 ASP A O   1 ? 
ATOM   1221 C CB  . ASP A 1 157 ? 22.160  10.346  20.166 1.000 38.611  0 157 ASP A CB  1 ? 
ATOM   1222 C CG  . ASP A 1 157 ? 22.772  10.419  21.548 1.000 45.216  0 157 ASP A CG  1 ? 
ATOM   1223 O OD1 . ASP A 1 157 ? 23.256  11.545  21.948 1.000 41.328  0 157 ASP A OD1 1 ? 
ATOM   1224 O OD2 . ASP A 1 157 ? 22.728  9.369   22.233 1.000 50.210  0 157 ASP A OD2 1 ? 
ATOM   1225 N N   . LEU A 1 158 ? 24.037  9.446   17.593 1.000 38.646  0 158 LEU A N   1 ? 
ATOM   1226 C CA  . LEU A 1 158 ? 25.134  8.621   17.116 1.000 36.506  0 158 LEU A CA  1 ? 
ATOM   1227 C C   . LEU A 1 158 ? 26.170  9.472   16.384 1.000 32.510  0 158 LEU A C   1 ? 
ATOM   1228 O O   . LEU A 1 158 ? 27.358  9.221   16.540 1.000 28.413  0 158 LEU A O   1 ? 
ATOM   1229 C CB  . LEU A 1 158 ? 24.579  7.530   16.198 1.000 35.340  0 158 LEU A CB  1 ? 
ATOM   1230 C CG  . LEU A 1 158 ? 25.614  6.545   15.666 1.000 39.836  0 158 LEU A CG  1 ? 
ATOM   1231 C CD1 . LEU A 1 158 ? 26.079  5.625   16.783 1.000 45.893  0 158 LEU A CD1 1 ? 
ATOM   1232 C CD2 . LEU A 1 158 ? 25.063  5.737   14.496 1.000 42.253  0 158 LEU A CD2 1 ? 
ATOM   1233 N N   . ILE A 1 159 ? 25.713  10.415  15.546 1.000 34.776  0 159 ILE A N   1 ? 
ATOM   1234 C CA  . ILE A 1 159 ? 26.609  11.304  14.824 1.000 38.993  0 159 ILE A CA  1 ? 
ATOM   1235 C C   . ILE A 1 159 ? 27.439  12.106  15.826 1.000 39.607  0 159 ILE A C   1 ? 
ATOM   1236 O O   . ILE A 1 159 ? 28.673  12.103  15.756 1.000 40.641  0 159 ILE A O   1 ? 
ATOM   1237 C CB  . ILE A 1 159 ? 25.840  12.214  13.839 1.000 42.661  0 159 ILE A CB  1 ? 
ATOM   1238 C CG1 . ILE A 1 159 ? 25.371  11.426  12.615 1.000 45.524  0 159 ILE A CG1 1 ? 
ATOM   1239 C CG2 . ILE A 1 159 ? 26.676  13.420  13.418 1.000 41.784  0 159 ILE A CG2 1 ? 
ATOM   1240 C CD1 . ILE A 1 159 ? 24.370  12.167  11.748 1.000 45.129  0 159 ILE A CD1 1 ? 
ATOM   1241 N N   . LYS A 1 160 ? 26.747  12.781  16.755 1.000 42.040  0 160 LYS A N   1 ? 
ATOM   1242 C CA  . LYS A 1 160 ? 27.385  13.590  17.783 1.000 41.330  0 160 LYS A CA  1 ? 
ATOM   1243 C C   . LYS A 1 160 ? 28.519  12.786  18.434 1.000 36.753  0 160 LYS A C   1 ? 
ATOM   1244 O O   . LYS A 1 160 ? 29.503  13.348  18.896 1.000 39.526  0 160 LYS A O   1 ? 
ATOM   1245 C CB  . LYS A 1 160 ? 26.325  14.091  18.779 1.000 38.992  0 160 LYS A CB  1 ? 
ATOM   1246 N N   . HIS A 1 161 ? 28.400  11.459  18.445 1.000 36.326  0 161 HIS A N   1 ? 
ATOM   1247 C CA  . HIS A 1 161 ? 29.343  10.599  19.133 1.000 34.065  0 161 HIS A CA  1 ? 
ATOM   1248 C C   . HIS A 1 161 ? 30.195  9.797   18.159 1.000 36.869  0 161 HIS A C   1 ? 
ATOM   1249 O O   . HIS A 1 161 ? 30.771  8.779   18.522 1.000 36.376  0 161 HIS A O   1 ? 
ATOM   1250 C CB  . HIS A 1 161 ? 28.580  9.699   20.092 1.000 35.405  0 161 HIS A CB  1 ? 
ATOM   1251 C CG  . HIS A 1 161 ? 27.855  10.569  21.049 1.000 44.246  0 161 HIS A CG  1 ? 
ATOM   1252 N ND1 . HIS A 1 161 ? 26.822  11.415  20.699 1.000 45.778  0 161 HIS A ND1 1 ? 
ATOM   1253 C CD2 . HIS A 1 161 ? 28.081  10.759  22.333 1.000 42.950  0 161 HIS A CD2 1 ? 
ATOM   1254 C CE1 . HIS A 1 161 ? 26.410  12.059  21.767 1.000 45.570  0 161 HIS A CE1 1 ? 
ATOM   1255 N NE2 . HIS A 1 161 ? 27.183  11.694  22.772 1.000 45.908  0 161 HIS A NE2 1 ? 
ATOM   1256 N N   . THR A 1 162 ? 30.348  10.316  16.948 1.000 36.890  0 162 THR A N   1 ? 
ATOM   1257 C CA  . THR A 1 162 ? 31.126  9.635   15.937 1.000 36.673  0 162 THR A CA  1 ? 
ATOM   1258 C C   . THR A 1 162 ? 32.165  10.617  15.433 1.000 36.160  0 162 THR A C   1 ? 
ATOM   1259 O O   . THR A 1 162 ? 31.814  11.681  14.921 1.000 27.835  0 162 THR A O   1 ? 
ATOM   1260 C CB  . THR A 1 162 ? 30.206  9.091   14.842 1.000 38.757  0 162 THR A CB  1 ? 
ATOM   1261 O OG1 . THR A 1 162 ? 29.291  8.193   15.469 1.000 35.380  0 162 THR A OG1 1 ? 
ATOM   1262 C CG2 . THR A 1 162 ? 30.953  8.363   13.752 1.000 43.117  0 162 THR A CG2 1 ? 
ATOM   1263 N N   . ASP A 1 163 ? 33.440  10.280  15.657 1.000 41.235  0 163 ASP A N   1 ? 
ATOM   1264 C CA  . ASP A 1 163 ? 34.512  11.191  15.274 1.000 50.376  0 163 ASP A CA  1 ? 
ATOM   1265 C C   . ASP A 1 163 ? 34.736  11.009  13.776 1.000 47.199  0 163 ASP A C   1 ? 
ATOM   1266 O O   . ASP A 1 163 ? 34.256  10.045  13.185 1.000 40.706  0 163 ASP A O   1 ? 
ATOM   1267 C CB  . ASP A 1 163 ? 35.777  11.082  16.156 1.000 56.021  0 163 ASP A CB  1 ? 
ATOM   1268 C CG  . ASP A 1 163 ? 36.457  9.720   16.267 1.000 53.141  0 163 ASP A CG  1 ? 
ATOM   1269 O OD1 . ASP A 1 163 ? 36.833  9.165   15.214 1.000 51.711  0 163 ASP A OD1 1 ? 
ATOM   1270 O OD2 . ASP A 1 163 ? 36.651  9.240   17.414 1.000 48.401  0 163 ASP A OD2 1 ? 
ATOM   1271 N N   . ASP A 1 164 ? 35.437  11.983  13.187 1.000 54.384  0 164 ASP A N   1 ? 
ATOM   1272 C CA  . ASP A 1 164 ? 35.586  12.088  11.747 1.000 60.580  0 164 ASP A CA  1 ? 
ATOM   1273 C C   . ASP A 1 164 ? 36.461  10.961  11.199 1.000 55.395  0 164 ASP A C   1 ? 
ATOM   1274 O O   . ASP A 1 164 ? 36.494  10.758  9.995  1.000 46.371  0 164 ASP A O   1 ? 
ATOM   1275 C CB  . ASP A 1 164 ? 36.144  13.462  11.363 1.000 67.060  0 164 ASP A CB  1 ? 
ATOM   1276 C CG  . ASP A 1 164 ? 35.106  14.579  11.376 1.000 73.288  0 164 ASP A CG  1 ? 
ATOM   1277 O OD1 . ASP A 1 164 ? 34.039  14.392  11.978 1.000 79.106  0 164 ASP A OD1 1 ? 
ATOM   1278 O OD2 . ASP A 1 164 ? 35.349  15.626  10.743 1.000 79.336  0 164 ASP A OD2 1 ? 
ATOM   1279 N N   . ASP A 1 165 ? 37.158  10.223  12.073 1.000 63.018  0 165 ASP A N   1 ? 
ATOM   1280 C CA  . ASP A 1 165 ? 38.026  9.126   11.645 1.000 66.531  0 165 ASP A CA  1 ? 
ATOM   1281 C C   . ASP A 1 165 ? 37.210  7.883   11.259 1.000 65.346  0 165 ASP A C   1 ? 
ATOM   1282 O O   . ASP A 1 165 ? 37.718  7.010   10.561 1.000 53.460  0 165 ASP A O   1 ? 
ATOM   1283 C CB  . ASP A 1 165 ? 39.090  8.815   12.711 1.000 65.972  0 165 ASP A CB  1 ? 
ATOM   1284 C CG  . ASP A 1 165 ? 40.164  9.887   12.871 1.000 68.256  0 165 ASP A CG  1 ? 
ATOM   1285 O OD1 . ASP A 1 165 ? 40.247  10.789  11.984 1.000 60.689  0 165 ASP A OD1 1 ? 
ATOM   1286 O OD2 . ASP A 1 165 ? 40.893  9.841   13.900 1.000 63.424  0 165 ASP A OD2 1 ? 
ATOM   1287 N N   . PHE A 1 166 ? 35.950  7.799   11.725 1.000 69.245  0 166 PHE A N   1 ? 
ATOM   1288 C CA  . PHE A 1 166 ? 34.974  6.847   11.210 1.000 65.191  0 166 PHE A CA  1 ? 
ATOM   1289 C C   . PHE A 1 166 ? 34.673  7.168   9.743  1.000 68.403  0 166 PHE A C   1 ? 
ATOM   1290 O O   . PHE A 1 166 ? 34.317  8.307   9.407  1.000 62.080  0 166 PHE A O   1 ? 
ATOM   1291 C CB  . PHE A 1 166 ? 33.676  6.874   12.028 1.000 61.601  0 166 PHE A CB  1 ? 
ATOM   1292 C CG  . PHE A 1 166 ? 33.711  6.187   13.375 1.000 58.091  0 166 PHE A CG  1 ? 
ATOM   1293 C CD1 . PHE A 1 166 ? 33.434  4.828   13.498 1.000 58.427  0 166 PHE A CD1 1 ? 
ATOM   1294 C CD2 . PHE A 1 166 ? 33.989  6.901   14.534 1.000 58.746  0 166 PHE A CD2 1 ? 
ATOM   1295 C CE1 . PHE A 1 166 ? 33.452  4.203   14.740 1.000 55.647  0 166 PHE A CE1 1 ? 
ATOM   1296 C CE2 . PHE A 1 166 ? 34.009  6.273   15.774 1.000 56.912  0 166 PHE A CE2 1 ? 
ATOM   1297 C CZ  . PHE A 1 166 ? 33.746  4.924   15.875 1.000 52.597  0 166 PHE A CZ  1 ? 
ATOM   1298 N N   . VAL A 1 167 ? 34.820  6.140   8.885  1.000 64.444  0 167 VAL A N   1 ? 
ATOM   1299 C CA  . VAL A 1 167 ? 34.618  6.275   7.449  1.000 61.761  0 167 VAL A CA  1 ? 
ATOM   1300 C C   . VAL A 1 167 ? 33.119  6.313   7.179  1.000 47.044  0 167 VAL A C   1 ? 
ATOM   1301 O O   . VAL A 1 167 ? 32.678  6.849   6.172  1.000 44.653  0 167 VAL A O   1 ? 
ATOM   1302 C CB  . VAL A 1 167 ? 35.305  5.132   6.672  1.000 68.624  0 167 VAL A CB  1 ? 
ATOM   1303 N N   . ASP A 1 168 ? 32.354  5.746   8.115  1.000 42.414  0 168 ASP A N   1 ? 
ATOM   1304 C CA  . ASP A 1 168 ? 30.910  5.597   8.009  1.000 41.087  0 168 ASP A CA  1 ? 
ATOM   1305 C C   . ASP A 1 168 ? 30.171  6.899   8.321  1.000 34.478  0 168 ASP A C   1 ? 
ATOM   1306 O O   . ASP A 1 168 ? 28.974  6.987   8.103  1.000 28.038  0 168 ASP A O   1 ? 
ATOM   1307 C CB  . ASP A 1 168 ? 30.456  4.492   8.975  1.000 46.371  0 168 ASP A CB  1 ? 
ATOM   1308 C CG  . ASP A 1 168 ? 29.146  3.802   8.628  1.000 48.943  0 168 ASP A CG  1 ? 
ATOM   1309 O OD1 . ASP A 1 168 ? 29.013  3.333   7.484  1.000 63.502  0 168 ASP A OD1 1 ? 
ATOM   1310 O OD2 . ASP A 1 168 ? 28.293  3.680   9.523  1.000 46.864  0 168 ASP A OD2 1 ? 
ATOM   1311 N N   . LYS A 1 169 ? 30.866  7.917   8.841  1.000 37.531  0 169 LYS A N   1 ? 
ATOM   1312 C CA  . LYS A 1 169 ? 30.193  9.090   9.377  1.000 38.520  0 169 LYS A CA  1 ? 
ATOM   1313 C C   . LYS A 1 169 ? 29.354  9.780   8.312  1.000 36.561  0 169 LYS A C   1 ? 
ATOM   1314 O O   . LYS A 1 169 ? 28.192  10.085  8.561  1.000 34.346  0 169 LYS A O   1 ? 
ATOM   1315 C CB  . LYS A 1 169 ? 31.175  10.094  9.974  1.000 42.334  0 169 LYS A CB  1 ? 
ATOM   1316 C CG  . LYS A 1 169 ? 30.496  11.267  10.663 1.000 44.512  0 169 LYS A CG  1 ? 
ATOM   1317 C CD  . LYS A 1 169 ? 31.448  12.215  11.308 1.000 48.960  0 169 LYS A CD  1 ? 
ATOM   1318 C CE  . LYS A 1 169 ? 30.776  13.103  12.331 1.000 49.816  0 169 LYS A CE  1 ? 
ATOM   1319 N NZ  . LYS A 1 169 ? 31.800  13.869  13.073 1.000 54.159  0 169 LYS A NZ  1 ? 
ATOM   1320 N N   . PRO A 1 170 ? 29.889  10.050  7.100  1.000 40.866  0 170 PRO A N   1 ? 
ATOM   1321 C CA  . PRO A 1 170 ? 29.095  10.717  6.064  1.000 41.868  0 170 PRO A CA  1 ? 
ATOM   1322 C C   . PRO A 1 170 ? 27.807  9.952   5.763  1.000 42.826  0 170 PRO A C   1 ? 
ATOM   1323 O O   . PRO A 1 170 ? 26.751  10.559  5.618  1.000 44.360  0 170 PRO A O   1 ? 
ATOM   1324 C CB  . PRO A 1 170 ? 30.020  10.745  4.834  1.000 43.486  0 170 PRO A CB  1 ? 
ATOM   1325 C CG  . PRO A 1 170 ? 31.420  10.517  5.383  1.000 40.841  0 170 PRO A CG  1 ? 
ATOM   1326 C CD  . PRO A 1 170 ? 31.247  9.699   6.647  1.000 38.854  0 170 PRO A CD  1 ? 
ATOM   1327 N N   . LYS A 1 171 ? 27.911  8.615   5.687  1.000 42.088  0 171 LYS A N   1 ? 
ATOM   1328 C CA  . LYS A 1 171 ? 26.754  7.752   5.491  1.000 47.320  0 171 LYS A CA  1 ? 
ATOM   1329 C C   . LYS A 1 171 ? 25.672  7.963   6.564  1.000 41.821  0 171 LYS A C   1 ? 
ATOM   1330 O O   . LYS A 1 171 ? 24.487  7.969   6.239  1.000 38.824  0 171 LYS A O   1 ? 
ATOM   1331 C CB  . LYS A 1 171 ? 27.188  6.282   5.445  1.000 50.633  0 171 LYS A CB  1 ? 
ATOM   1332 C CG  . LYS A 1 171 ? 27.777  5.842   4.120  1.000 52.371  0 171 LYS A CG  1 ? 
ATOM   1333 C CD  . LYS A 1 171 ? 28.331  4.451   4.134  1.000 55.761  0 171 LYS A CD  1 ? 
ATOM   1334 C CE  . LYS A 1 171 ? 29.374  4.221   3.055  1.000 56.999  0 171 LYS A CE  1 ? 
ATOM   1335 N NZ  . LYS A 1 171 ? 30.637  4.940   3.340  1.000 59.818  0 171 LYS A NZ  1 ? 
ATOM   1336 N N   . LEU A 1 172 ? 26.059  8.111   7.838  1.000 36.009  0 172 LEU A N   1 ? 
ATOM   1337 C CA  . LEU A 1 172 ? 25.094  8.480   8.863  1.000 36.182  0 172 LEU A CA  1 ? 
ATOM   1338 C C   . LEU A 1 172 ? 24.519  9.874   8.608  1.000 35.127  0 172 LEU A C   1 ? 
ATOM   1339 O O   . LEU A 1 172 ? 23.343  10.090  8.845  1.000 34.518  0 172 LEU A O   1 ? 
ATOM   1340 C CB  . LEU A 1 172 ? 25.726  8.429   10.246 1.000 33.944  0 172 LEU A CB  1 ? 
ATOM   1341 C CG  . LEU A 1 172 ? 26.140  7.066   10.786 1.000 37.973  0 172 LEU A CG  1 ? 
ATOM   1342 C CD1 . LEU A 1 172 ? 25.422  5.899   10.121 1.000 40.844  0 172 LEU A CD1 1 ? 
ATOM   1343 C CD2 . LEU A 1 172 ? 27.637  6.928   10.700 1.000 40.641  0 172 LEU A CD2 1 ? 
ATOM   1344 N N   . ILE A 1 173 ? 25.327  10.811  8.107  1.000 35.908  0 173 ILE A N   1 ? 
ATOM   1345 C CA  . ILE A 1 173 ? 24.851  12.178  7.922  1.000 43.793  0 173 ILE A CA  1 ? 
ATOM   1346 C C   . ILE A 1 173 ? 23.808  12.244  6.800  1.000 43.068  0 173 ILE A C   1 ? 
ATOM   1347 O O   . ILE A 1 173 ? 22.736  12.822  6.961  1.000 34.585  0 173 ILE A O   1 ? 
ATOM   1348 C CB  . ILE A 1 173 ? 26.031  13.139  7.678  1.000 43.560  0 173 ILE A CB  1 ? 
ATOM   1349 C CG1 . ILE A 1 173 ? 26.951  13.192  8.900  1.000 44.395  0 173 ILE A CG1 1 ? 
ATOM   1350 C CG2 . ILE A 1 173 ? 25.504  14.520  7.325  1.000 42.171  0 173 ILE A CG2 1 ? 
ATOM   1351 C CD1 . ILE A 1 173 ? 28.337  13.703  8.619  1.000 46.680  0 173 ILE A CD1 1 ? 
ATOM   1352 N N   . ASP A 1 174 ? 24.137  11.634  5.662  1.000 48.864  0 174 ASP A N   1 ? 
ATOM   1353 C CA  . ASP A 1 174 ? 23.188  11.447  4.577  1.000 50.893  0 174 ASP A CA  1 ? 
ATOM   1354 C C   . ASP A 1 174 ? 21.846  10.964  5.126  1.000 42.764  0 174 ASP A C   1 ? 
ATOM   1355 O O   . ASP A 1 174 ? 20.803  11.561  4.874  1.000 38.437  0 174 ASP A O   1 ? 
ATOM   1356 C CB  . ASP A 1 174 ? 23.757  10.444  3.574  1.000 58.269  0 174 ASP A CB  1 ? 
ATOM   1357 C CG  . ASP A 1 174 ? 23.032  10.418  2.243  1.000 77.243  0 174 ASP A CG  1 ? 
ATOM   1358 O OD1 . ASP A 1 174 ? 22.250  11.375  1.969  1.000 85.645  0 174 ASP A OD1 1 ? 
ATOM   1359 O OD2 . ASP A 1 174 ? 23.261  9.437   1.492  1.000 85.765  0 174 ASP A OD2 1 ? 
ATOM   1360 N N   . ALA A 1 175 ? 21.895  9.872   5.894  1.000 37.204  0 175 ALA A N   1 ? 
ATOM   1361 C CA  . ALA A 1 175 ? 20.688  9.249   6.394  1.000 37.797  0 175 ALA A CA  1 ? 
ATOM   1362 C C   . ALA A 1 175 ? 19.876  10.239  7.229  1.000 37.450  0 175 ALA A C   1 ? 
ATOM   1363 O O   . ALA A 1 175 ? 18.688  10.448  6.978  1.000 37.779  0 175 ALA A O   1 ? 
ATOM   1364 C CB  . ALA A 1 175 ? 21.026  7.998   7.171  1.000 39.154  0 175 ALA A CB  1 ? 
ATOM   1365 N N   . LEU A 1 176 ? 20.517  10.880  8.206  1.000 39.744  0 176 LEU A N   1 ? 
ATOM   1366 C CA  . LEU A 1 176 ? 19.789  11.812  9.054  1.000 44.035  0 176 LEU A CA  1 ? 
ATOM   1367 C C   . LEU A 1 176 ? 19.185  12.914  8.180  1.000 42.093  0 176 LEU A C   1 ? 
ATOM   1368 O O   . LEU A 1 176 ? 18.027  13.272  8.369  1.000 46.153  0 176 LEU A O   1 ? 
ATOM   1369 C CB  . LEU A 1 176 ? 20.695  12.346  10.169 1.000 46.737  0 176 LEU A CB  1 ? 
ATOM   1370 C CG  . LEU A 1 176 ? 20.063  13.359  11.134 1.000 48.946  0 176 LEU A CG  1 ? 
ATOM   1371 C CD1 . LEU A 1 176 ? 18.922  12.745  11.938 1.000 47.586  0 176 LEU A CD1 1 ? 
ATOM   1372 C CD2 . LEU A 1 176 ? 21.106  13.937  12.087 1.000 45.776  0 176 LEU A CD2 1 ? 
ATOM   1373 N N   . ASP A 1 177 ? 19.917  13.381  7.164  1.000 42.850  0 177 ASP A N   1 ? 
ATOM   1374 C CA  . ASP A 1 177 ? 19.405  14.443  6.310  1.000 45.215  0 177 ASP A CA  1 ? 
ATOM   1375 C C   . ASP A 1 177 ? 18.091  14.032  5.646  1.000 47.631  0 177 ASP A C   1 ? 
ATOM   1376 O O   . ASP A 1 177 ? 17.161  14.840  5.607  1.000 48.723  0 177 ASP A O   1 ? 
ATOM   1377 C CB  . ASP A 1 177 ? 20.395  14.869  5.221  1.000 46.068  0 177 ASP A CB  1 ? 
ATOM   1378 C CG  . ASP A 1 177 ? 19.696  15.628  4.102  1.000 56.129  0 177 ASP A CG  1 ? 
ATOM   1379 O OD1 . ASP A 1 177 ? 19.158  16.726  4.362  1.000 66.548  0 177 ASP A OD1 1 ? 
ATOM   1380 O OD2 . ASP A 1 177 ? 19.640  15.090  2.989  1.000 70.740  0 177 ASP A OD2 1 ? 
ATOM   1381 N N   . LYS A 1 178 ? 18.028  12.804  5.099  1.000 45.533  0 178 LYS A N   1 ? 
ATOM   1382 C CA  . LYS A 1 178 ? 16.876  12.401  4.304  1.000 50.222  0 178 LYS A CA  1 ? 
ATOM   1383 C C   . LYS A 1 178 ? 15.731  11.946  5.208  1.000 47.380  0 178 LYS A C   1 ? 
ATOM   1384 O O   . LYS A 1 178 ? 14.571  12.134  4.885  1.000 53.285  0 178 LYS A O   1 ? 
ATOM   1385 C CB  . LYS A 1 178 ? 17.241  11.288  3.318  1.000 55.125  0 178 LYS A CB  1 ? 
ATOM   1386 C CG  . LYS A 1 178 ? 18.285  11.665  2.277  1.000 61.978  0 178 LYS A CG  1 ? 
ATOM   1387 C CD  . LYS A 1 178 ? 18.246  10.768  1.052  1.000 74.853  0 178 LYS A CD  1 ? 
ATOM   1388 C CE  . LYS A 1 178 ? 18.882  11.386  -0.181 1.000 76.721  0 178 LYS A CE  1 ? 
ATOM   1389 N NZ  . LYS A 1 178 ? 20.363  11.370  -0.119 1.000 69.643  0 178 LYS A NZ  1 ? 
ATOM   1390 N N   . ILE A 1 179 ? 16.062  11.307  6.329  1.000 45.379  0 179 ILE A N   1 ? 
ATOM   1391 C CA  . ILE A 1 179 ? 15.048  10.860  7.260  1.000 43.417  0 179 ILE A CA  1 ? 
ATOM   1392 C C   . ILE A 1 179 ? 14.393  12.086  7.875  1.000 42.548  0 179 ILE A C   1 ? 
ATOM   1393 O O   . ILE A 1 179 ? 13.183  12.125  8.005  1.000 40.245  0 179 ILE A O   1 ? 
ATOM   1394 C CB  . ILE A 1 179 ? 15.639  9.892   8.305  1.000 43.318  0 179 ILE A CB  1 ? 
ATOM   1395 C CG1 . ILE A 1 179 ? 15.804  8.497   7.700  1.000 48.780  0 179 ILE A CG1 1 ? 
ATOM   1396 C CG2 . ILE A 1 179 ? 14.797  9.860   9.568  1.000 45.849  0 179 ILE A CG2 1 ? 
ATOM   1397 C CD1 . ILE A 1 179 ? 16.333  7.450   8.647  1.000 52.906  0 179 ILE A CD1 1 ? 
ATOM   1398 N N   . SER A 1 180 ? 15.200  13.088  8.233  1.000 48.078  0 180 SER A N   1 ? 
ATOM   1399 C CA  . SER A 1 180 ? 14.700  14.389  8.658  1.000 48.282  0 180 SER A CA  1 ? 
ATOM   1400 C C   . SER A 1 180 ? 13.626  14.925  7.715  1.000 40.878  0 180 SER A C   1 ? 
ATOM   1401 O O   . SER A 1 180 ? 12.639  15.484  8.168  1.000 38.449  0 180 SER A O   1 ? 
ATOM   1402 C CB  . SER A 1 180 ? 15.822  15.386  8.765  1.000 49.659  0 180 SER A CB  1 ? 
ATOM   1403 O OG  . SER A 1 180 ? 16.693  15.070  9.838  1.000 51.896  0 180 SER A OG  1 ? 
ATOM   1404 N N   . LYS A 1 181 ? 13.813  14.749  6.409  1.000 39.480  0 181 LYS A N   1 ? 
ATOM   1405 C CA  . LYS A 1 181 ? 12.863  15.301  5.457  1.000 47.564  0 181 LYS A CA  1 ? 
ATOM   1406 C C   . LYS A 1 181 ? 11.467  14.720  5.718  1.000 52.890  0 181 LYS A C   1 ? 
ATOM   1407 O O   . LYS A 1 181 ? 10.468  15.445  5.684  1.000 55.668  0 181 LYS A O   1 ? 
ATOM   1408 C CB  . LYS A 1 181 ? 13.308  15.044  4.005  1.000 51.658  0 181 LYS A CB  1 ? 
ATOM   1409 C CG  . LYS A 1 181 ? 14.470  15.878  3.471  1.000 48.423  0 181 LYS A CG  1 ? 
ATOM   1410 N N   . LEU A 1 182 ? 11.400  13.410  5.991  1.000 52.293  0 182 LEU A N   1 ? 
ATOM   1411 C CA  . LEU A 1 182 ? 10.115  12.740  6.136  1.000 57.505  0 182 LEU A CA  1 ? 
ATOM   1412 C C   . LEU A 1 182 ? 9.538   13.010  7.523  1.000 56.649  0 182 LEU A C   1 ? 
ATOM   1413 O O   . LEU A 1 182 ? 8.332   13.116  7.665  1.000 71.490  0 182 LEU A O   1 ? 
ATOM   1414 C CB  . LEU A 1 182 ? 10.288  11.238  5.876  1.000 56.975  0 182 LEU A CB  1 ? 
ATOM   1415 N N   . ALA A 1 183 ? 10.401  13.190  8.526  1.000 68.990  0 183 ALA A N   1 ? 
ATOM   1416 C CA  . ALA A 1 183 ? 9.966   13.405  9.900  1.000 79.600  0 183 ALA A CA  1 ? 
ATOM   1417 C C   . ALA A 1 183 ? 9.295   14.773  10.069 1.000 83.776  0 183 ALA A C   1 ? 
ATOM   1418 O O   . ALA A 1 183 ? 8.650   15.009  11.082 1.000 94.641  0 183 ALA A O   1 ? 
ATOM   1419 C CB  . ALA A 1 183 ? 11.132  13.247  10.845 1.000 79.832  0 183 ALA A CB  1 ? 
ATOM   1420 N N   . THR A 1 184 ? 9.419   15.651  9.064  1.000 83.810  0 184 THR A N   1 ? 
ATOM   1421 C CA  . THR A 1 184 ? 8.675   16.903  9.001  1.000 93.897  0 184 THR A CA  1 ? 
ATOM   1422 C C   . THR A 1 184 ? 7.160   16.693  9.012  1.000 94.412  0 184 THR A C   1 ? 
ATOM   1423 O O   . THR A 1 184 ? 6.410   17.592  9.388  1.000 93.055  0 184 THR A O   1 ? 
ATOM   1424 C CB  . THR A 1 184 ? 8.967   17.633  7.686  1.000 102.319 0 184 THR A CB  1 ? 
ATOM   1425 O OG1 . THR A 1 184 ? 10.378  17.817  7.574  1.000 105.236 0 184 THR A OG1 1 ? 
ATOM   1426 C CG2 . THR A 1 184 ? 8.236   18.954  7.580  1.000 100.636 0 184 THR A CG2 1 ? 
ATOM   1427 N N   . LEU A 1 185 ? 6.725   15.519  8.531  1.000 91.887  0 185 LEU A N   1 ? 
ATOM   1428 C CA  . LEU A 1 185 ? 5.322   15.232  8.264  1.000 83.833  0 185 LEU A CA  1 ? 
ATOM   1429 C C   . LEU A 1 185 ? 4.634   14.622  9.494  1.000 71.006  0 185 LEU A C   1 ? 
ATOM   1430 O O   . LEU A 1 185 ? 3.481   14.229  9.412  1.000 52.572  0 185 LEU A O   1 ? 
ATOM   1431 C CB  . LEU A 1 185 ? 5.231   14.255  7.077  1.000 75.093  0 185 LEU A CB  1 ? 
ATOM   1432 C CG  . LEU A 1 185 ? 6.118   14.531  5.863  1.000 69.728  0 185 LEU A CG  1 ? 
ATOM   1433 C CD1 . LEU A 1 185 ? 5.915   13.456  4.809  1.000 67.028  0 185 LEU A CD1 1 ? 
ATOM   1434 C CD2 . LEU A 1 185 ? 5.850   15.905  5.273  1.000 72.200  0 185 LEU A CD2 1 ? 
ATOM   1435 N N   . VAL A 1 186 ? 5.332   14.511  10.628 1.000 71.016  0 186 VAL A N   1 ? 
ATOM   1436 C CA  . VAL A 1 186 ? 4.853   13.716  11.751 1.000 77.895  0 186 VAL A CA  1 ? 
ATOM   1437 C C   . VAL A 1 186 ? 4.131   14.629  12.750 1.000 77.424  0 186 VAL A C   1 ? 
ATOM   1438 O O   . VAL A 1 186 ? 4.744   15.437  13.442 1.000 61.534  0 186 VAL A O   1 ? 
ATOM   1439 C CB  . VAL A 1 186 ? 6.026   12.925  12.373 1.000 84.588  0 186 VAL A CB  1 ? 
ATOM   1440 C CG1 . VAL A 1 186 ? 5.602   12.048  13.540 1.000 89.542  0 186 VAL A CG1 1 ? 
ATOM   1441 C CG2 . VAL A 1 186 ? 6.735   12.088  11.318 1.000 78.683  0 186 VAL A CG2 1 ? 
ATOM   1442 N N   . ASN A 1 187 ? 2.803   14.490  12.814 1.000 93.171  0 187 ASN A N   1 ? 
ATOM   1443 C CA  . ASN A 1 187 ? 1.973   15.305  13.689 1.000 96.916  0 187 ASN A CA  1 ? 
ATOM   1444 C C   . ASN A 1 187 ? 0.896   14.432  14.353 1.000 98.876  0 187 ASN A C   1 ? 
ATOM   1445 O O   . ASN A 1 187 ? 0.934   13.197  14.304 1.000 81.108  0 187 ASN A O   1 ? 
ATOM   1446 C CB  . ASN A 1 187 ? 1.404   16.504  12.917 1.000 88.609  0 187 ASN A CB  1 ? 
ATOM   1447 C CG  . ASN A 1 187 ? 0.757   16.116  11.603 1.000 83.920  0 187 ASN A CG  1 ? 
ATOM   1448 O OD1 . ASN A 1 187 ? 0.132   15.062  11.492 1.000 73.417  0 187 ASN A OD1 1 ? 
ATOM   1449 N ND2 . ASN A 1 187 ? 0.941   16.947  10.591 1.000 80.780  0 187 ASN A ND2 1 ? 
ATOM   1450 N N   . GLU A 1 188 ? -0.084  15.103  14.975 1.000 93.765  0 188 GLU A N   1 ? 
ATOM   1451 C CA  . GLU A 1 188 ? -1.071  14.470  15.828 1.000 91.175  0 188 GLU A CA  1 ? 
ATOM   1452 C C   . GLU A 1 188 ? -2.468  14.673  15.241 1.000 89.732  0 188 GLU A C   1 ? 
ATOM   1453 O O   . GLU A 1 188 ? -2.688  15.522  14.378 1.000 73.404  0 188 GLU A O   1 ? 
ATOM   1454 C CB  . GLU A 1 188 ? -0.954  15.056  17.239 1.000 100.473 0 188 GLU A CB  1 ? 
ATOM   1455 N N   . VAL A 1 189 ? -3.415  13.868  15.732 1.000 101.085 0 189 VAL A N   1 ? 
ATOM   1456 C CA  . VAL A 1 189 ? -4.759  13.808  15.184 1.000 92.508  0 189 VAL A CA  1 ? 
ATOM   1457 C C   . VAL A 1 189 ? -5.744  13.677  16.353 1.000 85.525  0 189 VAL A C   1 ? 
ATOM   1458 O O   . VAL A 1 189 ? -5.349  13.304  17.458 1.000 63.392  0 189 VAL A O   1 ? 
ATOM   1459 C CB  . VAL A 1 189 ? -4.860  12.667  14.145 1.000 72.384  0 189 VAL A CB  1 ? 
ATOM   1460 C CG1 . VAL A 1 189 ? -5.171  11.314  14.791 1.000 62.113  0 189 VAL A CG1 1 ? 
ATOM   1461 C CG2 . VAL A 1 189 ? -5.852  13.019  13.042 1.000 66.142  0 189 VAL A CG2 1 ? 
ATOM   1462 N N   . ILE A 1 190 ? -7.028  13.976  16.088 1.000 90.400  0 190 ILE A N   1 ? 
ATOM   1463 C CA  . ILE A 1 190 ? -7.970  14.430  17.107 1.000 94.045  0 190 ILE A CA  1 ? 
ATOM   1464 C C   . ILE A 1 190 ? -8.780  13.248  17.646 1.000 103.533 0 190 ILE A C   1 ? 
ATOM   1465 O O   . ILE A 1 190 ? -9.162  12.359  16.882 1.000 115.907 0 190 ILE A O   1 ? 
ATOM   1466 C CB  . ILE A 1 190 ? -8.942  15.510  16.563 1.000 89.038  0 190 ILE A CB  1 ? 
ATOM   1467 C CG1 . ILE A 1 190 ? -8.528  16.133  15.221 1.000 77.884  0 190 ILE A CG1 1 ? 
ATOM   1468 C CG2 . ILE A 1 190 ? -9.220  16.572  17.627 1.000 90.754  0 190 ILE A CG2 1 ? 
ATOM   1469 C CD1 . ILE A 1 190 ? -7.238  16.931  15.232 1.000 74.347  0 190 ILE A CD1 1 ? 
ATOM   1470 N N   . LYS A 1 191 ? -9.088  13.272  18.959 1.000 90.603  0 191 LYS A N   1 ? 
ATOM   1471 C CA  . LYS A 1 191 ? -10.147 12.424  19.499 1.000 67.498  0 191 LYS A CA  1 ? 
ATOM   1472 C C   . LYS A 1 191 ? -11.451 13.222  19.568 1.000 66.134  0 191 LYS A C   1 ? 
ATOM   1473 O O   . LYS A 1 191 ? -11.950 13.553  20.633 1.000 72.192  0 191 LYS A O   1 ? 
ATOM   1474 C CB  . LYS A 1 191 ? -9.770  11.729  20.817 1.000 61.738  0 191 LYS A CB  1 ? 
ATOM   1475 C CG  . LYS A 1 191 ? -9.212  12.562  21.965 1.000 44.391  0 191 LYS A CG  1 ? 
ATOM   1476 C CD  . LYS A 1 191 ? -9.753  11.993  23.272 1.000 34.714  0 191 LYS A CD  1 ? 
ATOM   1477 C CE  . LYS A 1 191 ? -11.120 12.487  23.683 1.000 21.044  0 191 LYS A CE  1 ? 
ATOM   1478 N NZ  . LYS A 1 191 ? -10.901 13.713  24.419 1.000 16.581  0 191 LYS A NZ  1 ? 
ATOM   1479 N N   . GLU A 1 192 ? -12.016 13.485  18.388 1.000 71.090  0 192 GLU A N   1 ? 
ATOM   1480 C CA  . GLU A 1 192 ? -13.183 14.339  18.214 1.000 74.862  0 192 GLU A CA  1 ? 
ATOM   1481 C C   . GLU A 1 192 ? -14.427 13.626  18.719 1.000 77.576  0 192 GLU A C   1 ? 
ATOM   1482 O O   . GLU A 1 192 ? -14.368 12.451  19.065 1.000 75.186  0 192 GLU A O   1 ? 
ATOM   1483 C CB  . GLU A 1 192 ? -13.384 14.632  16.724 1.000 83.979  0 192 GLU A CB  1 ? 
ATOM   1484 C CG  . GLU A 1 192 ? -14.269 15.826  16.404 1.000 82.609  0 192 GLU A CG  1 ? 
ATOM   1485 C CD  . GLU A 1 192 ? -14.351 16.143  14.919 1.000 81.715  0 192 GLU A CD  1 ? 
ATOM   1486 O OE1 . GLU A 1 192 ? -14.955 17.177  14.571 1.000 85.539  0 192 GLU A OE1 1 ? 
ATOM   1487 O OE2 . GLU A 1 192 ? -13.834 15.346  14.113 1.000 67.839  0 192 GLU A OE2 1 ? 
ATOM   1488 N N   . ARG A 1 193 ? -15.557 14.343  18.689 1.000 80.276  0 193 ARG A N   1 ? 
ATOM   1489 C CA  . ARG A 1 193 ? -16.872 13.770  18.942 1.000 82.656  0 193 ARG A CA  1 ? 
ATOM   1490 C C   . ARG A 1 193 ? -17.017 13.591  20.461 1.000 72.336  0 193 ARG A C   1 ? 
ATOM   1491 O O   . ARG A 1 193 ? -17.070 12.425  20.907 1.000 65.945  0 193 ARG A O   1 ? 
ATOM   1492 C CB  . ARG A 1 193 ? -17.115 12.465  18.153 1.000 80.580  0 193 ARG A CB  1 ? 
ATOM   1493 C CG  . ARG A 1 193 ? -17.028 12.550  16.627 1.000 78.463  0 193 ARG A CG  1 ? 
ATOM   1494 C CD  . ARG A 1 193 ? -17.897 13.581  15.904 1.000 73.450  0 193 ARG A CD  1 ? 
ATOM   1495 N NE  . ARG A 1 193 ? -19.173 13.823  16.572 1.000 76.124  0 193 ARG A NE  1 ? 
ATOM   1496 C CZ  . ARG A 1 193 ? -19.700 15.017  16.832 1.000 63.875  0 193 ARG A CZ  1 ? 
ATOM   1497 N NH1 . ARG A 1 193 ? -20.530 15.145  17.846 1.000 55.267  0 193 ARG A NH1 1 ? 
ATOM   1498 N NH2 . ARG A 1 193 ? -19.287 16.098  16.197 1.000 63.969  0 193 ARG A NH2 1 ? 
ATOM   1499 N N   . LYS B 1 1   ? -15.323 8.596   25.473 1.000 46.679  0 1   LYS B N   1 ? 
ATOM   1500 C CA  . LYS B 1 1   ? -15.909 7.329   24.952 1.000 49.255  0 1   LYS B CA  1 ? 
ATOM   1501 C C   . LYS B 1 1   ? -15.275 6.153   25.689 1.000 50.821  0 1   LYS B C   1 ? 
ATOM   1502 O O   . LYS B 1 1   ? -14.080 6.162   26.000 1.000 47.263  0 1   LYS B O   1 ? 
ATOM   1503 C CB  . LYS B 1 1   ? -15.693 7.167   23.442 1.000 50.508  0 1   LYS B CB  1 ? 
ATOM   1504 C CG  . LYS B 1 1   ? -16.461 6.026   22.782 1.000 52.578  0 1   LYS B CG  1 ? 
ATOM   1505 C CD  . LYS B 1 1   ? -15.681 5.375   21.665 1.000 56.276  0 1   LYS B CD  1 ? 
ATOM   1506 C CE  . LYS B 1 1   ? -15.251 6.357   20.591 1.000 56.949  0 1   LYS B CE  1 ? 
ATOM   1507 N NZ  . LYS B 1 1   ? -13.791 6.288   20.333 1.000 54.649  0 1   LYS B NZ  1 ? 
ATOM   1508 N N   . GLU B 1 2   ? -16.114 5.137   25.912 1.000 50.059  0 2   GLU B N   1 ? 
ATOM   1509 C CA  . GLU B 1 2   ? -15.803 4.004   26.755 1.000 52.657  0 2   GLU B CA  1 ? 
ATOM   1510 C C   . GLU B 1 2   ? -14.586 3.268   26.214 1.000 58.956  0 2   GLU B C   1 ? 
ATOM   1511 O O   . GLU B 1 2   ? -13.782 2.787   27.010 1.000 65.747  0 2   GLU B O   1 ? 
ATOM   1512 C CB  . GLU B 1 2   ? -17.000 3.050   26.849 1.000 48.794  0 2   GLU B CB  1 ? 
ATOM   1513 N N   . ASP B 1 3   ? -14.477 3.161   24.882 1.000 55.834  0 3   ASP B N   1 ? 
ATOM   1514 C CA  . ASP B 1 3   ? -13.525 2.243   24.277 1.000 51.225  0 3   ASP B CA  1 ? 
ATOM   1515 C C   . ASP B 1 3   ? -12.147 2.907   24.185 1.000 51.486  0 3   ASP B C   1 ? 
ATOM   1516 O O   . ASP B 1 3   ? -11.131 2.229   24.226 1.000 48.447  0 3   ASP B O   1 ? 
ATOM   1517 C CB  . ASP B 1 3   ? -14.054 1.689   22.950 1.000 46.320  0 3   ASP B CB  1 ? 
ATOM   1518 N N   . TYR B 1 4   ? -12.102 4.235   24.086 1.000 54.415  0 4   TYR B N   1 ? 
ATOM   1519 C CA  . TYR B 1 4   ? -10.844 4.951   24.197 1.000 48.089  0 4   TYR B CA  1 ? 
ATOM   1520 C C   . TYR B 1 4   ? -10.288 4.771   25.603 1.000 52.145  0 4   TYR B C   1 ? 
ATOM   1521 O O   . TYR B 1 4   ? -9.089  4.553   25.793 1.000 55.683  0 4   TYR B O   1 ? 
ATOM   1522 C CB  . TYR B 1 4   ? -11.039 6.442   23.943 1.000 44.309  0 4   TYR B CB  1 ? 
ATOM   1523 C CG  . TYR B 1 4   ? -9.789  7.277   24.036 1.000 46.431  0 4   TYR B CG  1 ? 
ATOM   1524 C CD1 . TYR B 1 4   ? -8.810  7.247   23.049 1.000 49.043  0 4   TYR B CD1 1 ? 
ATOM   1525 C CD2 . TYR B 1 4   ? -9.583  8.100   25.132 1.000 49.657  0 4   TYR B CD2 1 ? 
ATOM   1526 C CE1 . TYR B 1 4   ? -7.679  8.049   23.131 1.000 53.011  0 4   TYR B CE1 1 ? 
ATOM   1527 C CE2 . TYR B 1 4   ? -8.461  8.910   25.226 1.000 51.154  0 4   TYR B CE2 1 ? 
ATOM   1528 C CZ  . TYR B 1 4   ? -7.506  8.883   24.226 1.000 55.613  0 4   TYR B CZ  1 ? 
ATOM   1529 O OH  . TYR B 1 4   ? -6.401  9.688   24.357 1.000 59.650  0 4   TYR B OH  1 ? 
ATOM   1530 N N   . ARG B 1 5   ? -11.185 4.892   26.579 1.000 51.347  0 5   ARG B N   1 ? 
ATOM   1531 C CA  . ARG B 1 5   ? -10.848 4.782   27.990 1.000 47.692  0 5   ARG B CA  1 ? 
ATOM   1532 C C   . ARG B 1 5   ? -10.269 3.393   28.262 1.000 46.897  0 5   ARG B C   1 ? 
ATOM   1533 O O   . ARG B 1 5   ? -9.201  3.252   28.846 1.000 50.322  0 5   ARG B O   1 ? 
ATOM   1534 C CB  . ARG B 1 5   ? -12.110 5.051   28.810 1.000 45.444  0 5   ARG B CB  1 ? 
ATOM   1535 C CG  . ARG B 1 5   ? -11.867 5.323   30.280 1.000 43.181  0 5   ARG B CG  1 ? 
ATOM   1536 C CD  . ARG B 1 5   ? -13.155 5.633   31.030 1.000 39.704  0 5   ARG B CD  1 ? 
ATOM   1537 N NE  . ARG B 1 5   ? -12.850 5.894   32.427 1.000 39.194  0 5   ARG B NE  1 ? 
ATOM   1538 C CZ  . ARG B 1 5   ? -12.516 4.964   33.319 1.000 39.995  0 5   ARG B CZ  1 ? 
ATOM   1539 N NH1 . ARG B 1 5   ? -12.745 3.670   33.088 1.000 33.686  0 5   ARG B NH1 1 ? 
ATOM   1540 N NH2 . ARG B 1 5   ? -12.002 5.361   34.475 1.000 40.008  0 5   ARG B NH2 1 ? 
ATOM   1541 N N   . GLU B 1 6   ? -10.964 2.369   27.779 1.000 40.907  0 6   GLU B N   1 ? 
ATOM   1542 C CA  . GLU B 1 6   ? -10.539 1.001   27.960 1.000 46.610  0 6   GLU B CA  1 ? 
ATOM   1543 C C   . GLU B 1 6   ? -9.079  0.863   27.508 1.000 45.123  0 6   GLU B C   1 ? 
ATOM   1544 O O   . GLU B 1 6   ? -8.275  0.247   28.184 1.000 43.173  0 6   GLU B O   1 ? 
ATOM   1545 C CB  . GLU B 1 6   ? -11.555 0.120   27.228 1.000 53.877  0 6   GLU B CB  1 ? 
ATOM   1546 C CG  . GLU B 1 6   ? -11.573 -1.348  27.605 1.000 62.083  0 6   GLU B CG  1 ? 
ATOM   1547 C CD  . GLU B 1 6   ? -11.793 -1.689  29.072 1.000 71.007  0 6   GLU B CD  1 ? 
ATOM   1548 O OE1 . GLU B 1 6   ? -12.750 -1.130  29.675 1.000 62.305  0 6   GLU B OE1 1 ? 
ATOM   1549 O OE2 . GLU B 1 6   ? -11.019 -2.545  29.596 1.000 79.106  0 6   GLU B OE2 1 ? 
ATOM   1550 N N   . ARG B 1 7   ? -8.718  1.455   26.375 1.000 42.130  0 7   ARG B N   1 ? 
ATOM   1551 C CA  . ARG B 1 7   ? -7.369  1.368   25.845 1.000 42.366  0 7   ARG B CA  1 ? 
ATOM   1552 C C   . ARG B 1 7   ? -6.346  1.858   26.877 1.000 43.010  0 7   ARG B C   1 ? 
ATOM   1553 O O   . ARG B 1 7   ? -5.390  1.155   27.181 1.000 42.108  0 7   ARG B O   1 ? 
ATOM   1554 C CB  . ARG B 1 7   ? -7.289  2.199   24.565 1.000 48.821  0 7   ARG B CB  1 ? 
ATOM   1555 C CG  . ARG B 1 7   ? -6.336  1.663   23.512 1.000 55.993  0 7   ARG B CG  1 ? 
ATOM   1556 C CD  . ARG B 1 7   ? -6.646  2.174   22.106 1.000 57.142  0 7   ARG B CD  1 ? 
ATOM   1557 N NE  . ARG B 1 7   ? -5.471  2.001   21.256 1.000 59.644  0 7   ARG B NE  1 ? 
ATOM   1558 C CZ  . ARG B 1 7   ? -4.342  2.692   21.402 1.000 59.321  0 7   ARG B CZ  1 ? 
ATOM   1559 N NH1 . ARG B 1 7   ? -4.365  3.845   22.043 1.000 58.281  0 7   ARG B NH1 1 ? 
ATOM   1560 N NH2 . ARG B 1 7   ? -3.204  2.255   20.889 1.000 60.649  0 7   ARG B NH2 1 ? 
ATOM   1561 N N   . ILE B 1 8   ? -6.539  3.074   27.410 1.000 42.929  0 8   ILE B N   1 ? 
ATOM   1562 C CA  . ILE B 1 8   ? -5.640  3.639   28.406 1.000 38.422  0 8   ILE B CA  1 ? 
ATOM   1563 C C   . ILE B 1 8   ? -5.506  2.692   29.589 1.000 39.403  0 8   ILE B C   1 ? 
ATOM   1564 O O   . ILE B 1 8   ? -4.403  2.389   30.013 1.000 48.388  0 8   ILE B O   1 ? 
ATOM   1565 C CB  . ILE B 1 8   ? -6.117  5.003   28.903 1.000 38.980  0 8   ILE B CB  1 ? 
ATOM   1566 C CG1 . ILE B 1 8   ? -6.174  6.032   27.780 1.000 43.440  0 8   ILE B CG1 1 ? 
ATOM   1567 C CG2 . ILE B 1 8   ? -5.238  5.487   30.044 1.000 39.296  0 8   ILE B CG2 1 ? 
ATOM   1568 C CD1 . ILE B 1 8   ? -6.831  7.314   28.233 1.000 49.157  0 8   ILE B CD1 1 ? 
ATOM   1569 N N   . VAL B 1 9   ? -6.632  2.239   30.130 1.000 39.712  0 9   VAL B N   1 ? 
ATOM   1570 C CA  . VAL B 1 9   ? -6.614  1.274   31.216 1.000 41.455  0 9   VAL B CA  1 ? 
ATOM   1571 C C   . VAL B 1 9   ? -5.713  0.108   30.820 1.000 37.964  0 9   VAL B C   1 ? 
ATOM   1572 O O   . VAL B 1 9   ? -4.784  -0.194  31.547 1.000 40.941  0 9   VAL B O   1 ? 
ATOM   1573 C CB  . VAL B 1 9   ? -8.039  0.823   31.619 1.000 43.488  0 9   VAL B CB  1 ? 
ATOM   1574 C CG1 . VAL B 1 9   ? -8.018  -0.436  32.490 1.000 43.462  0 9   VAL B CG1 1 ? 
ATOM   1575 C CG2 . VAL B 1 9   ? -8.810  1.953   32.312 1.000 38.475  0 9   VAL B CG2 1 ? 
ATOM   1576 N N   . ASN B 1 10  ? -5.918  -0.466  29.631 1.000 41.877  0 10  ASN B N   1 ? 
ATOM   1577 C CA  . ASN B 1 10  ? -5.142  -1.612  29.177 1.000 43.956  0 10  ASN B CA  1 ? 
ATOM   1578 C C   . ASN B 1 10  ? -3.664  -1.271  29.007 1.000 38.497  0 10  ASN B C   1 ? 
ATOM   1579 O O   . ASN B 1 10  ? -2.828  -2.120  29.273 1.000 35.369  0 10  ASN B O   1 ? 
ATOM   1580 C CB  . ASN B 1 10  ? -5.693  -2.197  27.873 1.000 49.116  0 10  ASN B CB  1 ? 
ATOM   1581 C CG  . ASN B 1 10  ? -7.077  -2.781  28.045 1.000 52.410  0 10  ASN B CG  1 ? 
ATOM   1582 O OD1 . ASN B 1 10  ? -7.324  -3.597  28.935 1.000 50.807  0 10  ASN B OD1 1 ? 
ATOM   1583 N ND2 . ASN B 1 10  ? -7.988  -2.353  27.194 1.000 58.240  0 10  ASN B ND2 1 ? 
ATOM   1584 N N   . GLU B 1 11  ? -3.345  -0.046  28.569 1.000 41.728  0 11  GLU B N   1 ? 
ATOM   1585 C CA  . GLU B 1 11  ? -1.960  0.361   28.376 1.000 43.712  0 11  GLU B CA  1 ? 
ATOM   1586 C C   . GLU B 1 11  ? -1.271  0.406   29.733 1.000 41.904  0 11  GLU B C   1 ? 
ATOM   1587 O O   . GLU B 1 11  ? -0.154  -0.087  29.875 1.000 42.730  0 11  GLU B O   1 ? 
ATOM   1588 C CB  . GLU B 1 11  ? -1.831  1.719   27.668 1.000 46.138  0 11  GLU B CB  1 ? 
ATOM   1589 N N   . MET B 1 12  ? -1.957  0.969   30.737 1.000 43.196  0 12  MET B N   1 ? 
ATOM   1590 C CA  . MET B 1 12  ? -1.365  1.086   32.060 1.000 43.958  0 12  MET B CA  1 ? 
ATOM   1591 C C   . MET B 1 12  ? -1.058  -0.317  32.579 1.000 41.363  0 12  MET B C   1 ? 
ATOM   1592 O O   . MET B 1 12  ? 0.060   -0.601  33.015 1.000 42.557  0 12  MET B O   1 ? 
ATOM   1593 C CB  . MET B 1 12  ? -2.285  1.820   33.039 1.000 49.003  0 12  MET B CB  1 ? 
ATOM   1594 N N   . PHE B 1 13  ? -2.049  -1.200  32.465 1.000 34.922  0 13  PHE B N   1 ? 
ATOM   1595 C CA  . PHE B 1 13  ? -1.894  -2.570  32.911 1.000 34.790  0 13  PHE B CA  1 ? 
ATOM   1596 C C   . PHE B 1 13  ? -0.754  -3.257  32.165 1.000 35.319  0 13  PHE B C   1 ? 
ATOM   1597 O O   . PHE B 1 13  ? 0.067   -3.922  32.794 1.000 33.249  0 13  PHE B O   1 ? 
ATOM   1598 C CB  . PHE B 1 13  ? -3.193  -3.357  32.740 1.000 32.718  0 13  PHE B CB  1 ? 
ATOM   1599 C CG  . PHE B 1 13  ? -3.081  -4.748  33.290 1.000 33.007  0 13  PHE B CG  1 ? 
ATOM   1600 C CD1 . PHE B 1 13  ? -3.339  -4.990  34.627 1.000 30.942  0 13  PHE B CD1 1 ? 
ATOM   1601 C CD2 . PHE B 1 13  ? -2.605  -5.787  32.504 1.000 31.560  0 13  PHE B CD2 1 ? 
ATOM   1602 C CE1 . PHE B 1 13  ? -3.182  -6.262  35.153 1.000 32.385  0 13  PHE B CE1 1 ? 
ATOM   1603 C CE2 . PHE B 1 13  ? -2.459  -7.061  33.033 1.000 30.029  0 13  PHE B CE2 1 ? 
ATOM   1604 C CZ  . PHE B 1 13  ? -2.756  -7.294  34.353 1.000 30.924  0 13  PHE B CZ  1 ? 
ATOM   1605 N N   . ASP B 1 14  ? -0.704  -3.085  30.840 1.000 35.845  0 14  ASP B N   1 ? 
ATOM   1606 C CA  . ASP B 1 14  ? 0.254   -3.810  30.012 1.000 46.809  0 14  ASP B CA  1 ? 
ATOM   1607 C C   . ASP B 1 14  ? 1.669   -3.267  30.222 1.000 45.662  0 14  ASP B C   1 ? 
ATOM   1608 O O   . ASP B 1 14  ? 2.626   -4.036  30.219 1.000 41.628  0 14  ASP B O   1 ? 
ATOM   1609 C CB  . ASP B 1 14  ? -0.159  -3.814  28.531 1.000 52.198  0 14  ASP B CB  1 ? 
ATOM   1610 C CG  . ASP B 1 14  ? -1.331  -4.732  28.183 1.000 56.836  0 14  ASP B CG  1 ? 
ATOM   1611 O OD1 . ASP B 1 14  ? -1.795  -5.510  29.054 1.000 67.579  0 14  ASP B OD1 1 ? 
ATOM   1612 O OD2 . ASP B 1 14  ? -1.780  -4.669  27.040 1.000 64.294  0 14  ASP B OD2 1 ? 
ATOM   1613 N N   . THR B 1 15  ? 1.799   -1.954  30.437 1.000 44.884  0 15  THR B N   1 ? 
ATOM   1614 C CA  . THR B 1 15  ? 3.099   -1.374  30.721 1.000 41.164  0 15  THR B CA  1 ? 
ATOM   1615 C C   . THR B 1 15  ? 3.529   -1.632  32.161 1.000 39.736  0 15  THR B C   1 ? 
ATOM   1616 O O   . THR B 1 15  ? 4.717   -1.560  32.441 1.000 47.532  0 15  THR B O   1 ? 
ATOM   1617 C CB  . THR B 1 15  ? 3.148   0.117   30.376 1.000 43.392  0 15  THR B CB  1 ? 
ATOM   1618 O OG1 . THR B 1 15  ? 2.069   0.816   30.997 1.000 51.145  0 15  THR B OG1 1 ? 
ATOM   1619 C CG2 . THR B 1 15  ? 3.088   0.337   28.882 1.000 42.821  0 15  THR B CG2 1 ? 
ATOM   1620 N N   . GLU B 1 16  ? 2.595   -1.925  33.074 1.000 38.980  0 16  GLU B N   1 ? 
ATOM   1621 C CA  . GLU B 1 16  ? 2.962   -2.269  34.442 1.000 35.919  0 16  GLU B CA  1 ? 
ATOM   1622 C C   . GLU B 1 16  ? 3.541   -3.682  34.500 1.000 37.242  0 16  GLU B C   1 ? 
ATOM   1623 O O   . GLU B 1 16  ? 4.623   -3.879  35.046 1.000 37.295  0 16  GLU B O   1 ? 
ATOM   1624 C CB  . GLU B 1 16  ? 1.766   -2.208  35.384 1.000 38.416  0 16  GLU B CB  1 ? 
ATOM   1625 C CG  . GLU B 1 16  ? 2.158   -2.335  36.846 1.000 40.026  0 16  GLU B CG  1 ? 
ATOM   1626 C CD  . GLU B 1 16  ? 2.927   -1.143  37.397 1.000 46.610  0 16  GLU B CD  1 ? 
ATOM   1627 O OE1 . GLU B 1 16  ? 2.844   -0.023  36.815 1.000 48.069  0 16  GLU B OE1 1 ? 
ATOM   1628 O OE2 . GLU B 1 16  ? 3.599   -1.326  38.428 1.000 47.352  0 16  GLU B OE2 1 ? 
ATOM   1629 N N   . LYS B 1 17  ? 2.802   -4.653  33.942 1.000 37.163  0 17  LYS B N   1 ? 
ATOM   1630 C CA  . LYS B 1 17  ? 3.257   -6.029  33.850 1.000 34.907  0 17  LYS B CA  1 ? 
ATOM   1631 C C   . LYS B 1 17  ? 4.630   -6.038  33.203 1.000 30.990  0 17  LYS B C   1 ? 
ATOM   1632 O O   . LYS B 1 17  ? 5.528   -6.718  33.658 1.000 39.323  0 17  LYS B O   1 ? 
ATOM   1633 C CB  . LYS B 1 17  ? 2.281   -6.917  33.062 1.000 34.542  0 17  LYS B CB  1 ? 
ATOM   1634 N N   . SER B 1 18  ? 4.781   -5.291  32.123 1.000 33.413  0 18  SER B N   1 ? 
ATOM   1635 C CA  . SER B 1 18  ? 6.040   -5.221  31.406 1.000 34.846  0 18  SER B CA  1 ? 
ATOM   1636 C C   . SER B 1 18  ? 7.119   -4.738  32.368 1.000 39.752  0 18  SER B C   1 ? 
ATOM   1637 O O   . SER B 1 18  ? 8.186   -5.334  32.462 1.000 44.530  0 18  SER B O   1 ? 
ATOM   1638 C CB  . SER B 1 18  ? 5.884   -4.291  30.221 1.000 36.408  0 18  SER B CB  1 ? 
ATOM   1639 O OG  . SER B 1 18  ? 6.933   -4.422  29.284 1.000 36.922  0 18  SER B OG  1 ? 
ATOM   1640 N N   . TYR B 1 19  ? 6.776   -3.678  33.118 1.000 35.539  0 19  TYR B N   1 ? 
ATOM   1641 C CA  . TYR B 1 19  ? 7.698   -2.954  33.963 1.000 32.487  0 19  TYR B CA  1 ? 
ATOM   1642 C C   . TYR B 1 19  ? 8.139   -3.833  35.110 1.000 31.514  0 19  TYR B C   1 ? 
ATOM   1643 O O   . TYR B 1 19  ? 9.326   -3.984  35.326 1.000 29.469  0 19  TYR B O   1 ? 
ATOM   1644 C CB  . TYR B 1 19  ? 7.003   -1.690  34.455 1.000 35.003  0 19  TYR B CB  1 ? 
ATOM   1645 C CG  . TYR B 1 19  ? 7.665   -0.906  35.550 1.000 34.593  0 19  TYR B CG  1 ? 
ATOM   1646 C CD1 . TYR B 1 19  ? 9.006   -0.591  35.500 1.000 31.930  0 19  TYR B CD1 1 ? 
ATOM   1647 C CD2 . TYR B 1 19  ? 6.913   -0.403  36.610 1.000 38.101  0 19  TYR B CD2 1 ? 
ATOM   1648 C CE1 . TYR B 1 19  ? 9.599   0.162   36.505 1.000 33.697  0 19  TYR B CE1 1 ? 
ATOM   1649 C CE2 . TYR B 1 19  ? 7.488   0.378   37.604 1.000 37.203  0 19  TYR B CE2 1 ? 
ATOM   1650 C CZ  . TYR B 1 19  ? 8.842   0.660   37.555 1.000 33.376  0 19  TYR B CZ  1 ? 
ATOM   1651 O OH  . TYR B 1 19  ? 9.373   1.432   38.566 1.000 33.619  0 19  TYR B OH  1 ? 
ATOM   1652 N N   . VAL B 1 20  ? 7.185   -4.405  35.840 1.000 32.593  0 20  VAL B N   1 ? 
ATOM   1653 C CA  . VAL B 1 20  ? 7.547   -5.289  36.936 1.000 33.676  0 20  VAL B CA  1 ? 
ATOM   1654 C C   . VAL B 1 20  ? 8.347   -6.479  36.409 1.000 33.729  0 20  VAL B C   1 ? 
ATOM   1655 O O   . VAL B 1 20  ? 9.335   -6.844  37.020 1.000 33.639  0 20  VAL B O   1 ? 
ATOM   1656 C CB  . VAL B 1 20  ? 6.327   -5.753  37.743 1.000 33.641  0 20  VAL B CB  1 ? 
ATOM   1657 C CG1 . VAL B 1 20  ? 6.701   -6.834  38.742 1.000 34.562  0 20  VAL B CG1 1 ? 
ATOM   1658 C CG2 . VAL B 1 20  ? 5.670   -4.578  38.450 1.000 33.241  0 20  VAL B CG2 1 ? 
ATOM   1659 N N   . ASN B 1 21  ? 7.947   -7.065  35.274 1.000 35.209  0 21  ASN B N   1 ? 
ATOM   1660 C CA  . ASN B 1 21  ? 8.647   -8.224  34.746 1.000 35.132  0 21  ASN B CA  1 ? 
ATOM   1661 C C   . ASN B 1 21  ? 10.099  -7.844  34.428 1.000 34.500  0 21  ASN B C   1 ? 
ATOM   1662 O O   . ASN B 1 21  ? 11.022  -8.581  34.777 1.000 29.808  0 21  ASN B O   1 ? 
ATOM   1663 C CB  . ASN B 1 21  ? 7.919   -8.839  33.551 1.000 40.422  0 21  ASN B CB  1 ? 
ATOM   1664 C CG  . ASN B 1 21  ? 8.759   -9.903  32.853 1.000 50.817  0 21  ASN B CG  1 ? 
ATOM   1665 O OD1 . ASN B 1 21  ? 9.010   -10.975 33.404 1.000 47.791  0 21  ASN B OD1 1 ? 
ATOM   1666 N ND2 . ASN B 1 21  ? 9.207   -9.626  31.634 1.000 51.502  0 21  ASN B ND2 1 ? 
ATOM   1667 N N   . SER B 1 22  ? 10.322  -6.683  33.787 1.000 32.460  0 22  SER B N   1 ? 
ATOM   1668 C CA  . SER B 1 22  ? 11.673  -6.253  33.459 1.000 30.746  0 22  SER B CA  1 ? 
ATOM   1669 C C   . SER B 1 22  ? 12.488  -6.146  34.733 1.000 32.593  0 22  SER B C   1 ? 
ATOM   1670 O O   . SER B 1 22  ? 13.652  -6.557  34.768 1.000 33.946  0 22  SER B O   1 ? 
ATOM   1671 C CB  . SER B 1 22  ? 11.718  -4.942  32.739 1.000 33.705  0 22  SER B CB  1 ? 
ATOM   1672 O OG  . SER B 1 22  ? 11.131  -5.021  31.455 1.000 34.373  0 22  SER B OG  1 ? 
ATOM   1673 N N   . MET B 1 23  ? 11.857  -5.592  35.776 1.000 32.685  0 23  MET B N   1 ? 
ATOM   1674 C CA  . MET B 1 23  ? 12.553  -5.299  37.016 1.000 30.664  0 23  MET B CA  1 ? 
ATOM   1675 C C   . MET B 1 23  ? 13.014  -6.597  37.675 1.000 32.205  0 23  MET B C   1 ? 
ATOM   1676 O O   . MET B 1 23  ? 14.132  -6.661  38.201 1.000 30.358  0 23  MET B O   1 ? 
ATOM   1677 C CB  . MET B 1 23  ? 11.677  -4.500  37.983 1.000 33.145  0 23  MET B CB  1 ? 
ATOM   1678 C CG  . MET B 1 23  ? 11.661  -3.016  37.646 1.000 39.493  0 23  MET B CG  1 ? 
ATOM   1679 S SD  . MET B 1 23  ? 10.679  -2.040  38.813 1.000 44.435  0 23  MET B SD  1 ? 
ATOM   1680 C CE  . MET B 1 23  ? 12.084  -1.360  39.684 1.000 43.011  0 23  MET B CE  1 ? 
ATOM   1681 N N   . GLU B 1 24  ? 12.176  -7.643  37.606 1.000 30.577  0 24  GLU B N   1 ? 
ATOM   1682 C CA  . GLU B 1 24  ? 12.538  -8.900  38.221 1.000 30.433  0 24  GLU B CA  1 ? 
ATOM   1683 C C   . GLU B 1 24  ? 13.713  -9.500  37.470 1.000 26.429  0 24  GLU B C   1 ? 
ATOM   1684 O O   . GLU B 1 24  ? 14.497  -10.204 38.086 1.000 27.716  0 24  GLU B O   1 ? 
ATOM   1685 C CB  . GLU B 1 24  ? 11.357  -9.863  38.296 1.000 37.784  0 24  GLU B CB  1 ? 
ATOM   1686 C CG  . GLU B 1 24  ? 10.119  -9.287  38.994 1.000 42.336  0 24  GLU B CG  1 ? 
ATOM   1687 C CD  . GLU B 1 24  ? 9.509   -10.174 40.077 1.000 49.332  0 24  GLU B CD  1 ? 
ATOM   1688 O OE1 . GLU B 1 24  ? 8.521   -10.890 39.794 1.000 52.669  0 24  GLU B OE1 1 ? 
ATOM   1689 O OE2 . GLU B 1 24  ? 10.018  -10.147 41.221 1.000 56.961  0 24  GLU B OE2 1 ? 
ATOM   1690 N N   . ILE B 1 25  ? 13.848  -9.184  36.175 1.000 27.347  0 25  ILE B N   1 ? 
ATOM   1691 C CA  . ILE B 1 25  ? 14.873  -9.774  35.320 1.000 29.301  0 25  ILE B CA  1 ? 
ATOM   1692 C C   . ILE B 1 25  ? 16.217  -9.105  35.583 1.000 32.541  0 25  ILE B C   1 ? 
ATOM   1693 O O   . ILE B 1 25  ? 17.256  -9.711  35.401 1.000 41.997  0 25  ILE B O   1 ? 
ATOM   1694 C CB  . ILE B 1 25  ? 14.480  -9.700  33.829 1.000 32.504  0 25  ILE B CB  1 ? 
ATOM   1695 C CG1 . ILE B 1 25  ? 13.440  -10.759 33.461 1.000 35.573  0 25  ILE B CG1 1 ? 
ATOM   1696 C CG2 . ILE B 1 25  ? 15.697  -9.797  32.918 1.000 31.501  0 25  ILE B CG2 1 ? 
ATOM   1697 C CD1 . ILE B 1 25  ? 12.772  -10.493 32.121 1.000 36.881  0 25  ILE B CD1 1 ? 
ATOM   1698 N N   . CYS B 1 26  ? 16.193  -7.858  36.032 1.000 32.589  0 26  CYS B N   1 ? 
ATOM   1699 C CA  . CYS B 1 26  ? 17.391  -7.134  36.382 1.000 28.208  0 26  CYS B CA  1 ? 
ATOM   1700 C C   . CYS B 1 26  ? 17.890  -7.574  37.750 1.000 27.414  0 26  CYS B C   1 ? 
ATOM   1701 O O   . CYS B 1 26  ? 19.094  -7.591  38.001 1.000 27.121  0 26  CYS B O   1 ? 
ATOM   1702 C CB  . CYS B 1 26  ? 17.069  -5.651  36.405 1.000 32.674  0 26  CYS B CB  1 ? 
ATOM   1703 S SG  . CYS B 1 26  ? 18.461  -4.626  36.926 1.000 37.791  0 26  CYS B SG  1 ? 
ATOM   1704 N N   . ILE B 1 27  ? 16.973  -7.897  38.661 1.000 26.739  0 27  ILE B N   1 ? 
ATOM   1705 C CA  . ILE B 1 27  ? 17.388  -8.406  39.960 1.000 28.830  0 27  ILE B CA  1 ? 
ATOM   1706 C C   . ILE B 1 27  ? 17.959  -9.811  39.797 1.000 29.303  0 27  ILE B C   1 ? 
ATOM   1707 O O   . ILE B 1 27  ? 19.060  -10.112 40.271 1.000 29.480  0 27  ILE B O   1 ? 
ATOM   1708 C CB  . ILE B 1 27  ? 16.233  -8.402  40.987 1.000 28.492  0 27  ILE B CB  1 ? 
ATOM   1709 C CG1 . ILE B 1 27  ? 15.752  -6.977  41.282 1.000 32.726  0 27  ILE B CG1 1 ? 
ATOM   1710 C CG2 . ILE B 1 27  ? 16.653  -9.130  42.256 1.000 26.061  0 27  ILE B CG2 1 ? 
ATOM   1711 C CD1 . ILE B 1 27  ? 16.838  -6.074  41.831 1.000 36.818  0 27  ILE B CD1 1 ? 
ATOM   1712 N N   . LYS B 1 28  ? 17.171  -10.670 39.154 1.000 30.924  0 28  LYS B N   1 ? 
ATOM   1713 C CA  . LYS B 1 28  ? 17.520  -12.067 38.991 1.000 33.348  0 28  LYS B CA  1 ? 
ATOM   1714 C C   . LYS B 1 28  ? 18.769  -12.153 38.107 1.000 35.190  0 28  LYS B C   1 ? 
ATOM   1715 O O   . LYS B 1 28  ? 19.656  -12.956 38.389 1.000 34.827  0 28  LYS B O   1 ? 
ATOM   1716 C CB  . LYS B 1 28  ? 16.299  -12.818 38.448 1.000 31.252  0 28  LYS B CB  1 ? 
ATOM   1717 N N   . GLY B 1 29  ? 18.864  -11.269 37.094 1.000 34.462  0 29  GLY B N   1 ? 
ATOM   1718 C CA  . GLY B 1 29  ? 19.833  -11.389 36.012 1.000 32.984  0 29  GLY B CA  1 ? 
ATOM   1719 C C   . GLY B 1 29  ? 21.162  -10.670 36.253 1.000 38.760  0 29  GLY B C   1 ? 
ATOM   1720 O O   . GLY B 1 29  ? 22.209  -11.110 35.781 1.000 44.668  0 29  GLY B O   1 ? 
ATOM   1721 N N   . TYR B 1 30  ? 21.120  -9.540  36.965 1.000 40.647  0 30  TYR B N   1 ? 
ATOM   1722 C CA  . TYR B 1 30  ? 22.299  -8.718  37.179 1.000 38.679  0 30  TYR B CA  1 ? 
ATOM   1723 C C   . TYR B 1 30  ? 22.687  -8.677  38.655 1.000 37.954  0 30  TYR B C   1 ? 
ATOM   1724 O O   . TYR B 1 30  ? 23.794  -9.046  39.031 1.000 34.779  0 30  TYR B O   1 ? 
ATOM   1725 C CB  . TYR B 1 30  ? 22.035  -7.282  36.733 1.000 37.694  0 30  TYR B CB  1 ? 
ATOM   1726 C CG  . TYR B 1 30  ? 22.139  -7.066  35.254 1.000 34.476  0 30  TYR B CG  1 ? 
ATOM   1727 C CD1 . TYR B 1 30  ? 23.302  -7.393  34.583 1.000 40.024  0 30  TYR B CD1 1 ? 
ATOM   1728 C CD2 . TYR B 1 30  ? 21.070  -6.580  34.524 1.000 32.133  0 30  TYR B CD2 1 ? 
ATOM   1729 C CE1 . TYR B 1 30  ? 23.418  -7.226  33.212 1.000 41.738  0 30  TYR B CE1 1 ? 
ATOM   1730 C CE2 . TYR B 1 30  ? 21.162  -6.403  33.158 1.000 34.133  0 30  TYR B CE2 1 ? 
ATOM   1731 C CZ  . TYR B 1 30  ? 22.342  -6.725  32.500 1.000 36.978  0 30  TYR B CZ  1 ? 
ATOM   1732 O OH  . TYR B 1 30  ? 22.484  -6.533  31.153 1.000 33.147  0 30  TYR B OH  1 ? 
ATOM   1733 N N   . TYR B 1 31  ? 21.772  -8.171  39.475 1.000 39.461  0 31  TYR B N   1 ? 
ATOM   1734 C CA  . TYR B 1 31  ? 22.051  -7.922  40.873 1.000 36.094  0 31  TYR B CA  1 ? 
ATOM   1735 C C   . TYR B 1 31  ? 22.462  -9.197  41.588 1.000 32.640  0 31  TYR B C   1 ? 
ATOM   1736 O O   . TYR B 1 31  ? 23.485  -9.226  42.256 1.000 31.356  0 31  TYR B O   1 ? 
ATOM   1737 C CB  . TYR B 1 31  ? 20.815  -7.384  41.588 1.000 38.212  0 31  TYR B CB  1 ? 
ATOM   1738 C CG  . TYR B 1 31  ? 21.059  -7.146  43.050 1.000 38.516  0 31  TYR B CG  1 ? 
ATOM   1739 C CD1 . TYR B 1 31  ? 21.958  -6.182  43.464 1.000 34.520  0 31  TYR B CD1 1 ? 
ATOM   1740 C CD2 . TYR B 1 31  ? 20.450  -7.941  44.008 1.000 40.913  0 31  TYR B CD2 1 ? 
ATOM   1741 C CE1 . TYR B 1 31  ? 22.208  -5.972  44.804 1.000 39.141  0 31  TYR B CE1 1 ? 
ATOM   1742 C CE2 . TYR B 1 31  ? 20.672  -7.738  45.359 1.000 37.076  0 31  TYR B CE2 1 ? 
ATOM   1743 C CZ  . TYR B 1 31  ? 21.555  -6.748  45.753 1.000 39.806  0 31  TYR B CZ  1 ? 
ATOM   1744 O OH  . TYR B 1 31  ? 21.780  -6.525  47.080 1.000 34.041  0 31  TYR B OH  1 ? 
ATOM   1745 N N   . GLU B 1 32  ? 21.639  -10.239 41.501 1.000 36.245  0 32  GLU B N   1 ? 
ATOM   1746 C CA  . GLU B 1 32  ? 21.935  -11.454 42.252 1.000 35.930  0 32  GLU B CA  1 ? 
ATOM   1747 C C   . GLU B 1 32  ? 23.264  -12.069 41.826 1.000 35.547  0 32  GLU B C   1 ? 
ATOM   1748 O O   . GLU B 1 32  ? 24.068  -12.421 42.675 1.000 43.459  0 32  GLU B O   1 ? 
ATOM   1749 C CB  . GLU B 1 32  ? 20.780  -12.431 42.139 1.000 35.146  0 32  GLU B CB  1 ? 
ATOM   1750 C CG  . GLU B 1 32  ? 19.684  -12.057 43.094 1.000 41.104  0 32  GLU B CG  1 ? 
ATOM   1751 C CD  . GLU B 1 32  ? 18.426  -12.884 42.949 1.000 48.179  0 32  GLU B CD  1 ? 
ATOM   1752 O OE1 . GLU B 1 32  ? 18.337  -13.711 42.004 1.000 58.363  0 32  GLU B OE1 1 ? 
ATOM   1753 O OE2 . GLU B 1 32  ? 17.548  -12.698 43.794 1.000 55.590  0 32  GLU B OE2 1 ? 
ATOM   1754 N N   . PRO B 1 33  ? 23.569  -12.239 40.526 1.000 35.380  0 33  PRO B N   1 ? 
ATOM   1755 C CA  . PRO B 1 33  ? 24.890  -12.724 40.115 1.000 34.262  0 33  PRO B CA  1 ? 
ATOM   1756 C C   . PRO B 1 33  ? 26.082  -11.936 40.646 1.000 34.918  0 33  PRO B C   1 ? 
ATOM   1757 O O   . PRO B 1 33  ? 27.084  -12.494 41.072 1.000 37.467  0 33  PRO B O   1 ? 
ATOM   1758 C CB  . PRO B 1 33  ? 24.851  -12.571 38.596 1.000 35.989  0 33  PRO B CB  1 ? 
ATOM   1759 C CG  . PRO B 1 33  ? 23.387  -12.739 38.259 1.000 39.016  0 33  PRO B CG  1 ? 
ATOM   1760 C CD  . PRO B 1 33  ? 22.642  -12.081 39.402 1.000 35.755  0 33  PRO B CD  1 ? 
ATOM   1761 N N   . LEU B 1 34  ? 25.969  -10.613 40.608 1.000 38.106  0 34  LEU B N   1 ? 
ATOM   1762 C CA  . LEU B 1 34  ? 27.020  -9.769  41.139 1.000 36.319  0 34  LEU B CA  1 ? 
ATOM   1763 C C   . LEU B 1 34  ? 27.229  -10.014 42.637 1.000 37.689  0 34  LEU B C   1 ? 
ATOM   1764 O O   . LEU B 1 34  ? 28.355  -10.138 43.092 1.000 36.210  0 34  LEU B O   1 ? 
ATOM   1765 C CB  . LEU B 1 34  ? 26.631  -8.328  40.834 1.000 36.877  0 34  LEU B CB  1 ? 
ATOM   1766 C CG  . LEU B 1 34  ? 27.295  -7.708  39.614 1.000 41.374  0 34  LEU B CG  1 ? 
ATOM   1767 C CD1 . LEU B 1 34  ? 27.813  -8.769  38.636 1.000 41.521  0 34  LEU B CD1 1 ? 
ATOM   1768 C CD2 . LEU B 1 34  ? 26.312  -6.759  38.936 1.000 44.021  0 34  LEU B CD2 1 ? 
ATOM   1769 N N   . ILE B 1 35  ? 26.152  -10.127 43.415 1.000 44.627  0 35  ILE B N   1 ? 
ATOM   1770 C CA  . ILE B 1 35  ? 26.277  -10.309 44.857 1.000 49.337  0 35  ILE B CA  1 ? 
ATOM   1771 C C   . ILE B 1 35  ? 26.757  -11.719 45.215 1.000 55.910  0 35  ILE B C   1 ? 
ATOM   1772 O O   . ILE B 1 35  ? 27.386  -11.885 46.250 1.000 64.841  0 35  ILE B O   1 ? 
ATOM   1773 C CB  . ILE B 1 35  ? 24.952  -9.975  45.563 1.000 46.374  0 35  ILE B CB  1 ? 
ATOM   1774 C CG1 . ILE B 1 35  ? 24.606  -8.492  45.431 1.000 45.906  0 35  ILE B CG1 1 ? 
ATOM   1775 C CG2 . ILE B 1 35  ? 24.997  -10.405 47.016 1.000 46.563  0 35  ILE B CG2 1 ? 
ATOM   1776 C CD1 . ILE B 1 35  ? 25.543  -7.546  46.162 1.000 43.841  0 35  ILE B CD1 1 ? 
ATOM   1777 N N   . GLN B 1 36  ? 26.460  -12.728 44.381 1.000 60.192  0 36  GLN B N   1 ? 
ATOM   1778 C CA  . GLN B 1 36  ? 26.956  -14.077 44.601 1.000 58.463  0 36  GLN B CA  1 ? 
ATOM   1779 C C   . GLN B 1 36  ? 28.416  -14.178 44.161 1.000 60.091  0 36  GLN B C   1 ? 
ATOM   1780 O O   . GLN B 1 36  ? 29.179  -14.823 44.866 1.000 62.019  0 36  GLN B O   1 ? 
ATOM   1781 C CB  . GLN B 1 36  ? 26.096  -15.122 43.881 1.000 55.381  0 36  GLN B CB  1 ? 
ATOM   1782 N N   . SER B 1 37  ? 28.809  -13.556 43.030 1.000 69.566  0 37  SER B N   1 ? 
ATOM   1783 C CA  . SER B 1 37  ? 30.053  -13.923 42.360 1.000 77.306  0 37  SER B CA  1 ? 
ATOM   1784 C C   . SER B 1 37  ? 30.600  -12.832 41.435 1.000 88.333  0 37  SER B C   1 ? 
ATOM   1785 O O   . SER B 1 37  ? 30.067  -11.730 41.374 1.000 91.732  0 37  SER B O   1 ? 
ATOM   1786 C CB  . SER B 1 37  ? 29.830  -15.217 41.622 1.000 89.961  0 37  SER B CB  1 ? 
ATOM   1787 O OG  . SER B 1 37  ? 28.479  -15.323 41.179 1.000 100.498 0 37  SER B OG  1 ? 
ATOM   1788 N N   . GLY B 1 38  ? 31.697  -13.155 40.728 1.000 95.910  0 38  GLY B N   1 ? 
ATOM   1789 C CA  . GLY B 1 38  ? 32.468  -12.190 39.959 1.000 88.850  0 38  GLY B CA  1 ? 
ATOM   1790 C C   . GLY B 1 38  ? 33.124  -11.152 40.870 1.000 89.931  0 38  GLY B C   1 ? 
ATOM   1791 O O   . GLY B 1 38  ? 33.405  -10.045 40.427 1.000 93.496  0 38  GLY B O   1 ? 
ATOM   1792 N N   . HIS B 1 39  ? 33.420  -11.539 42.122 1.000 77.772  0 39  HIS B N   1 ? 
ATOM   1793 C CA  . HIS B 1 39  ? 33.553  -10.614 43.240 1.000 70.859  0 39  HIS B CA  1 ? 
ATOM   1794 C C   . HIS B 1 39  ? 34.558  -9.491  42.977 1.000 74.015  0 39  HIS B C   1 ? 
ATOM   1795 O O   . HIS B 1 39  ? 34.319  -8.371  43.415 1.000 77.224  0 39  HIS B O   1 ? 
ATOM   1796 C CB  . HIS B 1 39  ? 33.929  -11.360 44.529 1.000 60.273  0 39  HIS B CB  1 ? 
ATOM   1797 N N   . SER B 1 40  ? 35.663  -9.804  42.282 1.000 74.757  0 40  SER B N   1 ? 
ATOM   1798 C CA  . SER B 1 40  ? 36.910  -9.042  42.340 1.000 71.697  0 40  SER B CA  1 ? 
ATOM   1799 C C   . SER B 1 40  ? 36.752  -7.577  41.903 1.000 63.294  0 40  SER B C   1 ? 
ATOM   1800 O O   . SER B 1 40  ? 37.132  -6.653  42.621 1.000 54.840  0 40  SER B O   1 ? 
ATOM   1801 C CB  . SER B 1 40  ? 37.974  -9.756  41.525 1.000 73.780  0 40  SER B CB  1 ? 
ATOM   1802 N N   . VAL B 1 41  ? 36.190  -7.351  40.713 1.000 59.547  0 41  VAL B N   1 ? 
ATOM   1803 C CA  . VAL B 1 41  ? 36.024  -6.002  40.182 1.000 49.701  0 41  VAL B CA  1 ? 
ATOM   1804 C C   . VAL B 1 41  ? 34.641  -5.442  40.523 1.000 49.728  0 41  VAL B C   1 ? 
ATOM   1805 O O   . VAL B 1 41  ? 34.330  -4.317  40.122 1.000 56.822  0 41  VAL B O   1 ? 
ATOM   1806 C CB  . VAL B 1 41  ? 36.244  -5.977  38.660 1.000 47.241  0 41  VAL B CB  1 ? 
ATOM   1807 C CG1 . VAL B 1 41  ? 37.710  -6.066  38.326 1.000 53.733  0 41  VAL B CG1 1 ? 
ATOM   1808 C CG2 . VAL B 1 41  ? 35.466  -7.071  37.940 1.000 50.161  0 41  VAL B CG2 1 ? 
ATOM   1809 N N   . ALA B 1 42  ? 33.814  -6.229  41.243 1.000 43.280  0 42  ALA B N   1 ? 
ATOM   1810 C CA  . ALA B 1 42  ? 32.450  -5.857  41.583 1.000 39.866  0 42  ALA B CA  1 ? 
ATOM   1811 C C   . ALA B 1 42  ? 32.184  -6.080  43.072 1.000 40.455  0 42  ALA B C   1 ? 
ATOM   1812 O O   . ALA B 1 42  ? 31.399  -6.954  43.440 1.000 43.002  0 42  ALA B O   1 ? 
ATOM   1813 C CB  . ALA B 1 42  ? 31.511  -6.672  40.738 1.000 39.604  0 42  ALA B CB  1 ? 
ATOM   1814 N N   . PRO B 1 43  ? 32.791  -5.271  43.976 1.000 37.675  0 43  PRO B N   1 ? 
ATOM   1815 C CA  . PRO B 1 43  ? 32.552  -5.380  45.407 1.000 35.175  0 43  PRO B CA  1 ? 
ATOM   1816 C C   . PRO B 1 43  ? 31.094  -5.122  45.746 1.000 34.562  0 43  PRO B C   1 ? 
ATOM   1817 O O   . PRO B 1 43  ? 30.502  -4.213  45.158 1.000 30.982  0 43  PRO B O   1 ? 
ATOM   1818 C CB  . PRO B 1 43  ? 33.385  -4.246  46.011 1.000 33.772  0 43  PRO B CB  1 ? 
ATOM   1819 C CG  . PRO B 1 43  ? 34.457  -4.048  45.007 1.000 34.973  0 43  PRO B CG  1 ? 
ATOM   1820 C CD  . PRO B 1 43  ? 33.730  -4.181  43.688 1.000 37.312  0 43  PRO B CD  1 ? 
ATOM   1821 N N   . ALA B 1 44  ? 30.589  -5.891  46.730 1.000 34.624  0 44  ALA B N   1 ? 
ATOM   1822 C CA  . ALA B 1 44  ? 29.210  -5.876  47.186 1.000 34.537  0 44  ALA B CA  1 ? 
ATOM   1823 C C   . ALA B 1 44  ? 28.764  -4.458  47.485 1.000 33.619  0 44  ALA B C   1 ? 
ATOM   1824 O O   . ALA B 1 44  ? 27.640  -4.100  47.181 1.000 40.207  0 44  ALA B O   1 ? 
ATOM   1825 C CB  . ALA B 1 44  ? 29.067  -6.714  48.425 1.000 32.665  0 44  ALA B CB  1 ? 
ATOM   1826 N N   . ASP B 1 45  ? 29.634  -3.668  48.102 1.000 32.782  0 45  ASP B N   1 ? 
ATOM   1827 C CA  . ASP B 1 45  ? 29.238  -2.335  48.517 1.000 36.621  0 45  ASP B CA  1 ? 
ATOM   1828 C C   . ASP B 1 45  ? 28.986  -1.482  47.284 1.000 34.915  0 45  ASP B C   1 ? 
ATOM   1829 O O   . ASP B 1 45  ? 27.987  -0.774  47.219 1.000 39.294  0 45  ASP B O   1 ? 
ATOM   1830 C CB  . ASP B 1 45  ? 30.281  -1.731  49.467 1.000 46.213  0 45  ASP B CB  1 ? 
ATOM   1831 C CG  . ASP B 1 45  ? 30.132  -2.149  50.926 1.000 46.315  0 45  ASP B CG  1 ? 
ATOM   1832 O OD1 . ASP B 1 45  ? 29.026  -2.631  51.304 1.000 44.329  0 45  ASP B OD1 1 ? 
ATOM   1833 O OD2 . ASP B 1 45  ? 31.129  -1.996  51.670 1.000 44.812  0 45  ASP B OD2 1 ? 
ATOM   1834 N N   . LYS B 1 46  ? 29.882  -1.584  46.295 1.000 33.976  0 46  LYS B N   1 ? 
ATOM   1835 C CA  . LYS B 1 46  ? 29.708  -0.905  45.023 1.000 29.921  0 46  LYS B CA  1 ? 
ATOM   1836 C C   . LYS B 1 46  ? 28.411  -1.379  44.369 1.000 29.283  0 46  LYS B C   1 ? 
ATOM   1837 O O   . LYS B 1 46  ? 27.556  -0.564  44.050 1.000 32.596  0 46  LYS B O   1 ? 
ATOM   1838 C CB  . LYS B 1 46  ? 30.962  -1.073  44.161 1.000 29.089  0 46  LYS B CB  1 ? 
ATOM   1839 C CG  . LYS B 1 46  ? 32.110  -0.167  44.586 1.000 30.544  0 46  LYS B CG  1 ? 
ATOM   1840 N N   . VAL B 1 47  ? 28.235  -2.692  44.205 1.000 25.991  0 47  VAL B N   1 ? 
ATOM   1841 C CA  . VAL B 1 47  ? 27.007  -3.205  43.625 1.000 24.631  0 47  VAL B CA  1 ? 
ATOM   1842 C C   . VAL B 1 47  ? 25.776  -2.729  44.411 1.000 27.291  0 47  VAL B C   1 ? 
ATOM   1843 O O   . VAL B 1 47  ? 24.763  -2.369  43.840 1.000 28.170  0 47  VAL B O   1 ? 
ATOM   1844 C CB  . VAL B 1 47  ? 27.017  -4.738  43.604 1.000 24.344  0 47  VAL B CB  1 ? 
ATOM   1845 C CG1 . VAL B 1 47  ? 25.742  -5.249  42.979 1.000 23.656  0 47  VAL B CG1 1 ? 
ATOM   1846 C CG2 . VAL B 1 47  ? 28.224  -5.329  42.905 1.000 27.203  0 47  VAL B CG2 1 ? 
ATOM   1847 N N   . ASN B 1 48  ? 25.807  -2.784  45.743 1.000 28.125  0 48  ASN B N   1 ? 
ATOM   1848 C CA  . ASN B 1 48  ? 24.618  -2.466  46.497 1.000 26.148  0 48  ASN B CA  1 ? 
ATOM   1849 C C   . ASN B 1 48  ? 24.328  -0.979  46.381 1.000 28.317  0 48  ASN B C   1 ? 
ATOM   1850 O O   . ASN B 1 48  ? 23.165  -0.612  46.365 1.000 29.146  0 48  ASN B O   1 ? 
ATOM   1851 C CB  . ASN B 1 48  ? 24.711  -2.840  47.967 1.000 26.117  0 48  ASN B CB  1 ? 
ATOM   1852 C CG  . ASN B 1 48  ? 24.430  -4.301  48.224 1.000 25.578  0 48  ASN B CG  1 ? 
ATOM   1853 O OD1 . ASN B 1 48  ? 25.209  -5.002  48.876 1.000 28.671  0 48  ASN B OD1 1 ? 
ATOM   1854 N ND2 . ASN B 1 48  ? 23.289  -4.761  47.774 1.000 25.490  0 48  ASN B ND2 1 ? 
ATOM   1855 N N   . ALA B 1 49  ? 25.353  -0.116  46.326 1.000 29.400  0 49  ALA B N   1 ? 
ATOM   1856 C CA  . ALA B 1 49  ? 25.075  1.314   46.224 1.000 30.423  0 49  ALA B CA  1 ? 
ATOM   1857 C C   . ALA B 1 49  ? 24.426  1.572   44.869 1.000 31.491  0 49  ALA B C   1 ? 
ATOM   1858 O O   . ALA B 1 49  ? 23.556  2.433   44.751 1.000 31.008  0 49  ALA B O   1 ? 
ATOM   1859 C CB  . ALA B 1 49  ? 26.304  2.161   46.408 1.000 30.933  0 49  ALA B CB  1 ? 
ATOM   1860 N N   . VAL B 1 50  ? 24.806  0.766   43.871 1.000 29.440  0 50  VAL B N   1 ? 
ATOM   1861 C CA  . VAL B 1 50  ? 24.226  0.868   42.543 1.000 30.779  0 50  VAL B CA  1 ? 
ATOM   1862 C C   . VAL B 1 50  ? 22.733  0.507   42.558 1.000 33.716  0 50  VAL B C   1 ? 
ATOM   1863 O O   . VAL B 1 50  ? 21.912  1.205   41.942 1.000 36.250  0 50  VAL B O   1 ? 
ATOM   1864 C CB  . VAL B 1 50  ? 24.996  0.005   41.529 1.000 26.773  0 50  VAL B CB  1 ? 
ATOM   1865 C CG1 . VAL B 1 50  ? 24.194  -0.207  40.268 1.000 28.409  0 50  VAL B CG1 1 ? 
ATOM   1866 C CG2 . VAL B 1 50  ? 26.341  0.605   41.193 1.000 26.096  0 50  VAL B CG2 1 ? 
ATOM   1867 N N   . PHE B 1 51  ? 22.378  -0.584  43.245 1.000 28.891  0 51  PHE B N   1 ? 
ATOM   1868 C CA  . PHE B 1 51  ? 21.022  -1.104  43.164 1.000 29.710  0 51  PHE B CA  1 ? 
ATOM   1869 C C   . PHE B 1 51  ? 20.151  -0.622  44.320 1.000 25.864  0 51  PHE B C   1 ? 
ATOM   1870 O O   . PHE B 1 51  ? 18.993  -1.002  44.432 1.000 26.177  0 51  PHE B O   1 ? 
ATOM   1871 C CB  . PHE B 1 51  ? 21.043  -2.636  43.128 1.000 32.741  0 51  PHE B CB  1 ? 
ATOM   1872 C CG  . PHE B 1 51  ? 21.471  -3.199  41.801 1.000 29.861  0 51  PHE B CG  1 ? 
ATOM   1873 C CD1 . PHE B 1 51  ? 22.805  -3.236  41.437 1.000 32.770  0 51  PHE B CD1 1 ? 
ATOM   1874 C CD2 . PHE B 1 51  ? 20.546  -3.648  40.908 1.000 30.662  0 51  PHE B CD2 1 ? 
ATOM   1875 C CE1 . PHE B 1 51  ? 23.205  -3.753  40.224 1.000 30.766  0 51  PHE B CE1 1 ? 
ATOM   1876 C CE2 . PHE B 1 51  ? 20.951  -4.161  39.686 1.000 34.381  0 51  PHE B CE2 1 ? 
ATOM   1877 C CZ  . PHE B 1 51  ? 22.273  -4.221  39.353 1.000 31.462  0 51  PHE B CZ  1 ? 
ATOM   1878 N N   . LEU B 1 52  ? 20.691  0.233   45.174 1.000 25.072  0 52  LEU B N   1 ? 
ATOM   1879 C CA  . LEU B 1 52  ? 20.006  0.571   46.396 1.000 27.010  0 52  LEU B CA  1 ? 
ATOM   1880 C C   . LEU B 1 52  ? 18.616  1.123   46.089 1.000 28.904  0 52  LEU B C   1 ? 
ATOM   1881 O O   . LEU B 1 52  ? 18.504  2.002   45.246 1.000 30.480  0 52  LEU B O   1 ? 
ATOM   1882 C CB  . LEU B 1 52  ? 20.868  1.586   47.149 1.000 28.356  0 52  LEU B CB  1 ? 
ATOM   1883 C CG  . LEU B 1 52  ? 20.432  1.834   48.593 1.000 26.555  0 52  LEU B CG  1 ? 
ATOM   1884 C CD1 . LEU B 1 52  ? 20.711  0.603   49.436 1.000 25.166  0 52  LEU B CD1 1 ? 
ATOM   1885 C CD2 . LEU B 1 52  ? 21.116  3.067   49.152 1.000 24.683  0 52  LEU B CD2 1 ? 
ATOM   1886 N N   . HIS B 1 53  ? 17.584  0.581   46.770 1.000 27.669  0 53  HIS B N   1 ? 
ATOM   1887 C CA  . HIS B 1 53  ? 16.197  1.023   46.694 1.000 29.010  0 53  HIS B CA  1 ? 
ATOM   1888 C C   . HIS B 1 53  ? 15.487  0.486   45.459 1.000 31.681  0 53  HIS B C   1 ? 
ATOM   1889 O O   . HIS B 1 53  ? 14.516  1.083   45.004 1.000 45.472  0 53  HIS B O   1 ? 
ATOM   1890 C CB  . HIS B 1 53  ? 16.039  2.557   46.731 1.000 29.267  0 53  HIS B CB  1 ? 
ATOM   1891 C CG  . HIS B 1 53  ? 16.704  3.207   47.885 1.000 34.822  0 53  HIS B CG  1 ? 
ATOM   1892 N ND1 . HIS B 1 53  ? 16.432  2.878   49.205 1.000 33.014  0 53  HIS B ND1 1 ? 
ATOM   1893 C CD2 . HIS B 1 53  ? 17.673  4.163   47.902 1.000 35.150  0 53  HIS B CD2 1 ? 
ATOM   1894 C CE1 . HIS B 1 53  ? 17.202  3.628   49.989 1.000 31.383  0 53  HIS B CE1 1 ? 
ATOM   1895 N NE2 . HIS B 1 53  ? 17.963  4.409   49.217 1.000 36.017  0 53  HIS B NE2 1 ? 
ATOM   1896 N N   . PHE B 1 54  ? 15.978  -0.589  44.853 1.000 36.383  0 54  PHE B N   1 ? 
ATOM   1897 C CA  . PHE B 1 54  ? 15.423  -1.038  43.582 1.000 31.864  0 54  PHE B CA  1 ? 
ATOM   1898 C C   . PHE B 1 54  ? 14.443  -2.168  43.858 1.000 32.791  0 54  PHE B C   1 ? 
ATOM   1899 O O   . PHE B 1 54  ? 13.295  -2.120  43.409 1.000 33.515  0 54  PHE B O   1 ? 
ATOM   1900 C CB  . PHE B 1 54  ? 16.534  -1.422  42.618 1.000 32.140  0 54  PHE B CB  1 ? 
ATOM   1901 C CG  . PHE B 1 54  ? 16.099  -1.713  41.200 1.000 39.431  0 54  PHE B CG  1 ? 
ATOM   1902 C CD1 . PHE B 1 54  ? 15.864  -0.691  40.297 1.000 44.865  0 54  PHE B CD1 1 ? 
ATOM   1903 C CD2 . PHE B 1 54  ? 15.959  -3.015  40.750 1.000 40.504  0 54  PHE B CD2 1 ? 
ATOM   1904 C CE1 . PHE B 1 54  ? 15.506  -0.959  38.980 1.000 51.871  0 54  PHE B CE1 1 ? 
ATOM   1905 C CE2 . PHE B 1 54  ? 15.621  -3.284  39.429 1.000 50.774  0 54  PHE B CE2 1 ? 
ATOM   1906 C CZ  . PHE B 1 54  ? 15.375  -2.257  38.544 1.000 49.899  0 54  PHE B CZ  1 ? 
ATOM   1907 N N   . GLN B 1 55  ? 14.878  -3.155  44.647 1.000 31.150  0 55  GLN B N   1 ? 
ATOM   1908 C CA  . GLN B 1 55  ? 13.979  -4.178  45.154 1.000 31.539  0 55  GLN B CA  1 ? 
ATOM   1909 C C   . GLN B 1 55  ? 12.766  -3.527  45.824 1.000 28.297  0 55  GLN B C   1 ? 
ATOM   1910 O O   . GLN B 1 55  ? 11.659  -4.018  45.748 1.000 26.645  0 55  GLN B O   1 ? 
ATOM   1911 C CB  . GLN B 1 55  ? 14.785  -5.079  46.081 1.000 33.757  0 55  GLN B CB  1 ? 
ATOM   1912 C CG  . GLN B 1 55  ? 13.959  -6.140  46.768 1.000 41.110  0 55  GLN B CG  1 ? 
ATOM   1913 C CD  . GLN B 1 55  ? 13.158  -7.013  45.830 1.000 40.457  0 55  GLN B CD  1 ? 
ATOM   1914 O OE1 . GLN B 1 55  ? 11.929  -6.890  45.742 1.000 33.093  0 55  GLN B OE1 1 ? 
ATOM   1915 N NE2 . GLN B 1 55  ? 13.862  -7.915  45.159 1.000 38.099  0 55  GLN B NE2 1 ? 
ATOM   1916 N N   . SER B 1 56  ? 12.972  -2.385  46.466 1.000 30.819  0 56  SER B N   1 ? 
ATOM   1917 C CA  . SER B 1 56  ? 11.929  -1.666  47.183 1.000 29.753  0 56  SER B CA  1 ? 
ATOM   1918 C C   . SER B 1 56  ? 10.873  -1.182  46.210 1.000 28.384  0 56  SER B C   1 ? 
ATOM   1919 O O   . SER B 1 56  ? 9.692   -1.229  46.498 1.000 29.465  0 56  SER B O   1 ? 
ATOM   1920 C CB  . SER B 1 56  ? 12.528  -0.505  47.932 1.000 33.346  0 56  SER B CB  1 ? 
ATOM   1921 O OG  . SER B 1 56  ? 12.193  -0.497  49.294 1.000 38.759  0 56  SER B OG  1 ? 
ATOM   1922 N N   . VAL B 1 57  ? 11.305  -0.728  45.037 1.000 30.199  0 57  VAL B N   1 ? 
ATOM   1923 C CA  . VAL B 1 57  ? 10.379  -0.286  44.010 1.000 29.372  0 57  VAL B CA  1 ? 
ATOM   1924 C C   . VAL B 1 57  ? 9.698   -1.498  43.386 1.000 30.268  0 57  VAL B C   1 ? 
ATOM   1925 O O   . VAL B 1 57  ? 8.488   -1.524  43.246 1.000 27.630  0 57  VAL B O   1 ? 
ATOM   1926 C CB  . VAL B 1 57  ? 11.084  0.574   42.960 1.000 27.046  0 57  VAL B CB  1 ? 
ATOM   1927 C CG1 . VAL B 1 57  ? 10.189  0.832   41.763 1.000 28.231  0 57  VAL B CG1 1 ? 
ATOM   1928 C CG2 . VAL B 1 57  ? 11.532  1.869   43.594 1.000 29.541  0 57  VAL B CG2 1 ? 
ATOM   1929 N N   . LEU B 1 58  ? 10.475  -2.526  43.035 1.000 34.593  0 58  LEU B N   1 ? 
ATOM   1930 C CA  . LEU B 1 58  ? 9.877   -3.753  42.540 1.000 34.287  0 58  LEU B CA  1 ? 
ATOM   1931 C C   . LEU B 1 58  ? 8.780   -4.203  43.504 1.000 30.869  0 58  LEU B C   1 ? 
ATOM   1932 O O   . LEU B 1 58  ? 7.677   -4.511  43.102 1.000 34.377  0 58  LEU B O   1 ? 
ATOM   1933 C CB  . LEU B 1 58  ? 10.975  -4.800  42.364 1.000 36.616  0 58  LEU B CB  1 ? 
ATOM   1934 C CG  . LEU B 1 58  ? 10.497  -6.181  41.930 1.000 39.673  0 58  LEU B CG  1 ? 
ATOM   1935 C CD1 . LEU B 1 58  ? 11.676  -7.031  41.500 1.000 37.036  0 58  LEU B CD1 1 ? 
ATOM   1936 C CD2 . LEU B 1 58  ? 9.763   -6.877  43.060 1.000 47.625  0 58  LEU B CD2 1 ? 
ATOM   1937 N N   . SER B 1 59  ? 9.049   -4.182  44.800 1.000 33.517  0 59  SER B N   1 ? 
ATOM   1938 C CA  . SER B 1 59  ? 8.109   -4.695  45.783 1.000 36.492  0 59  SER B CA  1 ? 
ATOM   1939 C C   . SER B 1 59  ? 6.720   -4.039  45.652 1.000 30.368  0 59  SER B C   1 ? 
ATOM   1940 O O   . SER B 1 59  ? 5.688   -4.701  45.489 1.000 25.774  0 59  SER B O   1 ? 
ATOM   1941 C CB  . SER B 1 59  ? 8.756   -4.497  47.130 1.000 41.689  0 59  SER B CB  1 ? 
ATOM   1942 O OG  . SER B 1 59  ? 7.980   -5.064  48.163 1.000 64.034  0 59  SER B OG  1 ? 
ATOM   1943 N N   . ILE B 1 60  ? 6.681   -2.708  45.690 1.000 27.254  0 60  ILE B N   1 ? 
ATOM   1944 C CA  . ILE B 1 60  ? 5.409   -2.011  45.764 1.000 27.355  0 60  ILE B CA  1 ? 
ATOM   1945 C C   . ILE B 1 60  ? 4.682   -2.059  44.419 1.000 28.353  0 60  ILE B C   1 ? 
ATOM   1946 O O   . ILE B 1 60  ? 3.448   -2.056  44.360 1.000 25.304  0 60  ILE B O   1 ? 
ATOM   1947 C CB  . ILE B 1 60  ? 5.584   -0.575  46.296 1.000 25.610  0 60  ILE B CB  1 ? 
ATOM   1948 C CG1 . ILE B 1 60  ? 6.311   0.369   45.345 1.000 26.442  0 60  ILE B CG1 1 ? 
ATOM   1949 C CG2 . ILE B 1 60  ? 6.260   -0.590  47.647 1.000 26.483  0 60  ILE B CG2 1 ? 
ATOM   1950 C CD1 . ILE B 1 60  ? 6.138   1.824   45.745 1.000 26.648  0 60  ILE B CD1 1 ? 
ATOM   1951 N N   . ASN B 1 61  ? 5.453   -2.078  43.335 1.000 30.789  0 61  ASN B N   1 ? 
ATOM   1952 C CA  . ASN B 1 61  ? 4.914   -2.236  41.990 1.000 28.656  0 61  ASN B CA  1 ? 
ATOM   1953 C C   . ASN B 1 61  ? 4.393   -3.653  41.766 1.000 29.037  0 61  ASN B C   1 ? 
ATOM   1954 O O   . ASN B 1 61  ? 3.336   -3.829  41.184 1.000 26.942  0 61  ASN B O   1 ? 
ATOM   1955 C CB  . ASN B 1 61  ? 5.953   -1.853  40.944 1.000 28.224  0 61  ASN B CB  1 ? 
ATOM   1956 C CG  . ASN B 1 61  ? 6.020   -0.356  40.788 1.000 29.896  0 61  ASN B CG  1 ? 
ATOM   1957 O OD1 . ASN B 1 61  ? 5.245   0.230   40.050 1.000 35.912  0 61  ASN B OD1 1 ? 
ATOM   1958 N ND2 . ASN B 1 61  ? 6.934   0.282   41.485 1.000 34.704  0 61  ASN B ND2 1 ? 
ATOM   1959 N N   . LYS B 1 62  ? 5.081   -4.674  42.275 1.000 35.055  0 62  LYS B N   1 ? 
ATOM   1960 C CA  . LYS B 1 62  ? 4.555   -6.031  42.160 1.000 38.358  0 62  LYS B CA  1 ? 
ATOM   1961 C C   . LYS B 1 62  ? 3.204   -6.159  42.882 1.000 34.387  0 62  LYS B C   1 ? 
ATOM   1962 O O   . LYS B 1 62  ? 2.315   -6.843  42.381 1.000 36.680  0 62  LYS B O   1 ? 
ATOM   1963 C CB  . LYS B 1 62  ? 5.576   -7.074  42.636 1.000 43.924  0 62  LYS B CB  1 ? 
ATOM   1964 C CG  . LYS B 1 62  ? 4.981   -8.418  43.037 1.000 53.276  0 62  LYS B CG  1 ? 
ATOM   1965 C CD  . LYS B 1 62  ? 5.717   -9.617  42.501 1.000 62.248  0 62  LYS B CD  1 ? 
ATOM   1966 C CE  . LYS B 1 62  ? 7.087   -9.797  43.101 1.000 66.044  0 62  LYS B CE  1 ? 
ATOM   1967 N NZ  . LYS B 1 62  ? 7.565   -11.173 42.832 1.000 74.206  0 62  LYS B NZ  1 ? 
ATOM   1968 N N   . GLU B 1 63  ? 3.027   -5.509  44.041 1.000 32.559  0 63  GLU B N   1 ? 
ATOM   1969 C CA  . GLU B 1 63  ? 1.753   -5.537  44.752 1.000 31.016  0 63  GLU B CA  1 ? 
ATOM   1970 C C   . GLU B 1 63  ? 0.681   -4.784  43.961 1.000 30.925  0 63  GLU B C   1 ? 
ATOM   1971 O O   . GLU B 1 63  ? -0.480  -5.189  43.955 1.000 33.705  0 63  GLU B O   1 ? 
ATOM   1972 C CB  . GLU B 1 63  ? 1.867   -4.934  46.162 1.000 28.920  0 63  GLU B CB  1 ? 
ATOM   1973 N N   . LEU B 1 64  ? 1.065   -3.692  43.294 1.000 27.189  0 64  LEU B N   1 ? 
ATOM   1974 C CA  . LEU B 1 64  ? 0.124   -2.934  42.494 1.000 30.776  0 64  LEU B CA  1 ? 
ATOM   1975 C C   . LEU B 1 64  ? -0.372  -3.793  41.340 1.000 33.618  0 64  LEU B C   1 ? 
ATOM   1976 O O   . LEU B 1 64  ? -1.567  -3.793  41.043 1.000 28.725  0 64  LEU B O   1 ? 
ATOM   1977 C CB  . LEU B 1 64  ? 0.795   -1.667  41.952 1.000 34.836  0 64  LEU B CB  1 ? 
ATOM   1978 C CG  . LEU B 1 64  ? -0.008  -0.872  40.922 1.000 32.359  0 64  LEU B CG  1 ? 
ATOM   1979 C CD1 . LEU B 1 64  ? -1.245  -0.274  41.551 1.000 28.014  0 64  LEU B CD1 1 ? 
ATOM   1980 C CD2 . LEU B 1 64  ? 0.847   0.211   40.284 1.000 34.380  0 64  LEU B CD2 1 ? 
ATOM   1981 N N   . LEU B 1 65  ? 0.562   -4.513  40.697 1.000 37.543  0 65  LEU B N   1 ? 
ATOM   1982 C CA  . LEU B 1 65  ? 0.236   -5.410  39.597 1.000 37.138  0 65  LEU B CA  1 ? 
ATOM   1983 C C   . LEU B 1 65  ? -0.667  -6.538  40.093 1.000 38.894  0 65  LEU B C   1 ? 
ATOM   1984 O O   . LEU B 1 65  ? -1.626  -6.903  39.423 1.000 44.867  0 65  LEU B O   1 ? 
ATOM   1985 C CB  . LEU B 1 65  ? 1.536   -5.958  39.009 1.000 34.565  0 65  LEU B CB  1 ? 
ATOM   1986 C CG  . LEU B 1 65  ? 1.386   -6.947  37.853 1.000 37.052  0 65  LEU B CG  1 ? 
ATOM   1987 C CD1 . LEU B 1 65  ? 0.811   -6.279  36.597 1.000 35.059  0 65  LEU B CD1 1 ? 
ATOM   1988 C CD2 . LEU B 1 65  ? 2.735   -7.594  37.550 1.000 37.377  0 65  LEU B CD2 1 ? 
ATOM   1989 N N   . LYS B 1 66  ? -0.364  -7.075  41.276 1.000 37.892  0 66  LYS B N   1 ? 
ATOM   1990 C CA  . LYS B 1 66  ? -1.176  -8.118  41.865 1.000 39.087  0 66  LYS B CA  1 ? 
ATOM   1991 C C   . LYS B 1 66  ? -2.633  -7.653  41.892 1.000 40.082  0 66  LYS B C   1 ? 
ATOM   1992 O O   . LYS B 1 66  ? -3.522  -8.301  41.337 1.000 45.230  0 66  LYS B O   1 ? 
ATOM   1993 C CB  . LYS B 1 66  ? -0.643  -8.454  43.261 1.000 45.193  0 66  LYS B CB  1 ? 
ATOM   1994 C CG  . LYS B 1 66  ? -1.091  -9.811  43.787 1.000 45.918  0 66  LYS B CG  1 ? 
ATOM   1995 C CD  . LYS B 1 66  ? -0.497  -10.185 45.124 1.000 50.966  0 66  LYS B CD  1 ? 
ATOM   1996 C CE  . LYS B 1 66  ? -0.680  -11.657 45.426 1.000 57.851  0 66  LYS B CE  1 ? 
ATOM   1997 N NZ  . LYS B 1 66  ? -0.181  -12.015 46.775 1.000 60.275  0 66  LYS B NZ  1 ? 
ATOM   1998 N N   . ASN B 1 67  ? -2.871  -6.485  42.481 1.000 35.274  0 67  ASN B N   1 ? 
ATOM   1999 C CA  . ASN B 1 67  ? -4.233  -6.025  42.692 1.000 37.887  0 67  ASN B CA  1 ? 
ATOM   2000 C C   . ASN B 1 67  ? -4.879  -5.714  41.340 1.000 34.130  0 67  ASN B C   1 ? 
ATOM   2001 O O   . ASN B 1 67  ? -6.058  -5.973  41.113 1.000 36.802  0 67  ASN B O   1 ? 
ATOM   2002 C CB  . ASN B 1 67  ? -4.253  -4.842  43.671 1.000 41.925  0 67  ASN B CB  1 ? 
ATOM   2003 C CG  . ASN B 1 67  ? -3.577  -5.130  44.995 1.000 44.805  0 67  ASN B CG  1 ? 
ATOM   2004 O OD1 . ASN B 1 67  ? -3.535  -6.278  45.460 1.000 42.975  0 67  ASN B OD1 1 ? 
ATOM   2005 N ND2 . ASN B 1 67  ? -3.056  -4.072  45.606 1.000 49.026  0 67  ASN B ND2 1 ? 
ATOM   2006 N N   . MET B 1 68  ? -4.086  -5.186  40.419 1.000 35.777  0 68  MET B N   1 ? 
ATOM   2007 C CA  . MET B 1 68  ? -4.570  -4.911  39.078 1.000 39.638  0 68  MET B CA  1 ? 
ATOM   2008 C C   . MET B 1 68  ? -4.959  -6.225  38.417 1.000 41.793  0 68  MET B C   1 ? 
ATOM   2009 O O   . MET B 1 68  ? -5.984  -6.297  37.734 1.000 43.062  0 68  MET B O   1 ? 
ATOM   2010 C CB  . MET B 1 68  ? -3.508  -4.208  38.236 1.000 38.837  0 68  MET B CB  1 ? 
ATOM   2011 C CG  . MET B 1 68  ? -3.472  -2.707  38.463 1.000 40.954  0 68  MET B CG  1 ? 
ATOM   2012 S SD  . MET B 1 68  ? -2.179  -1.863  37.493 1.000 48.136  0 68  MET B SD  1 ? 
ATOM   2013 C CE  . MET B 1 68  ? -3.036  -1.560  35.952 1.000 57.972  0 68  MET B CE  1 ? 
ATOM   2014 N N   . THR B 1 69  ? -4.144  -7.261  38.648 1.000 38.136  0 69  THR B N   1 ? 
ATOM   2015 C CA  . THR B 1 69  ? -4.411  -8.552  38.042 1.000 39.501  0 69  THR B CA  1 ? 
ATOM   2016 C C   . THR B 1 69  ? -5.665  -9.157  38.673 1.000 42.843  0 69  THR B C   1 ? 
ATOM   2017 O O   . THR B 1 69  ? -6.493  -9.722  37.964 1.000 39.005  0 69  THR B O   1 ? 
ATOM   2018 C CB  . THR B 1 69  ? -3.179  -9.463  38.113 1.000 38.507  0 69  THR B CB  1 ? 
ATOM   2019 O OG1 . THR B 1 69  ? -2.134  -8.866  37.342 1.000 43.742  0 69  THR B OG1 1 ? 
ATOM   2020 C CG2 . THR B 1 69  ? -3.447  -10.847 37.575 1.000 37.731  0 69  THR B CG2 1 ? 
ATOM   2021 N N   . GLU B 1 70  ? -5.814  -9.005  39.996 1.000 44.553  0 70  GLU B N   1 ? 
ATOM   2022 C CA  . GLU B 1 70  ? -6.980  -9.520  40.685 1.000 45.794  0 70  GLU B CA  1 ? 
ATOM   2023 C C   . GLU B 1 70  ? -8.233  -8.932  40.046 1.000 48.493  0 70  GLU B C   1 ? 
ATOM   2024 O O   . GLU B 1 70  ? -9.148  -9.668  39.723 1.000 65.442  0 70  GLU B O   1 ? 
ATOM   2025 C CB  . GLU B 1 70  ? -6.920  -9.230  42.190 1.000 57.918  0 70  GLU B CB  1 ? 
ATOM   2026 C CG  . GLU B 1 70  ? -5.796  -9.982  42.914 1.000 66.390  0 70  GLU B CG  1 ? 
ATOM   2027 C CD  . GLU B 1 70  ? -6.041  -10.402 44.359 1.000 68.738  0 70  GLU B CD  1 ? 
ATOM   2028 O OE1 . GLU B 1 70  ? -6.955  -9.839  45.010 1.000 73.061  0 70  GLU B OE1 1 ? 
ATOM   2029 O OE2 . GLU B 1 70  ? -5.344  -11.337 44.813 1.000 62.056  0 70  GLU B OE2 1 ? 
ATOM   2030 N N   . LEU B 1 71  ? -8.264  -7.615  39.842 1.000 48.425  0 71  LEU B N   1 ? 
ATOM   2031 C CA  . LEU B 1 71  ? -9.421  -6.939  39.267 1.000 42.815  0 71  LEU B CA  1 ? 
ATOM   2032 C C   . LEU B 1 71  ? -9.650  -7.371  37.814 1.000 38.933  0 71  LEU B C   1 ? 
ATOM   2033 O O   . LEU B 1 71  ? -10.774 -7.543  37.375 1.000 34.823  0 71  LEU B O   1 ? 
ATOM   2034 C CB  . LEU B 1 71  ? -9.186  -5.424  39.328 1.000 44.567  0 71  LEU B CB  1 ? 
ATOM   2035 C CG  . LEU B 1 71  ? -9.055  -4.802  40.717 1.000 45.457  0 71  LEU B CG  1 ? 
ATOM   2036 C CD1 . LEU B 1 71  ? -8.896  -3.289  40.595 1.000 45.324  0 71  LEU B CD1 1 ? 
ATOM   2037 C CD2 . LEU B 1 71  ? -10.239 -5.160  41.620 1.000 44.175  0 71  LEU B CD2 1 ? 
ATOM   2038 N N   . LYS B 1 72  ? -8.592  -7.511  37.024 1.000 44.848  0 72  LYS B N   1 ? 
ATOM   2039 C CA  . LYS B 1 72  ? -8.762  -7.780  35.600 1.000 52.787  0 72  LYS B CA  1 ? 
ATOM   2040 C C   . LYS B 1 72  ? -9.464  -9.132  35.380 1.000 59.851  0 72  LYS B C   1 ? 
ATOM   2041 O O   . LYS B 1 72  ? -10.431 -9.225  34.626 1.000 64.313  0 72  LYS B O   1 ? 
ATOM   2042 C CB  . LYS B 1 72  ? -7.399  -7.748  34.897 1.000 54.371  0 72  LYS B CB  1 ? 
ATOM   2043 C CG  . LYS B 1 72  ? -7.442  -7.592  33.382 1.000 57.656  0 72  LYS B CG  1 ? 
ATOM   2044 C CD  . LYS B 1 72  ? -6.191  -8.106  32.684 1.000 62.224  0 72  LYS B CD  1 ? 
ATOM   2045 C CE  . LYS B 1 72  ? -6.073  -7.617  31.256 1.000 66.267  0 72  LYS B CE  1 ? 
ATOM   2046 N NZ  . LYS B 1 72  ? -7.348  -7.771  30.518 1.000 72.847  0 72  LYS B NZ  1 ? 
ATOM   2047 N N   . GLU B 1 73  ? -8.985  -10.186 36.051 1.000 57.481  0 73  GLU B N   1 ? 
ATOM   2048 C CA  . GLU B 1 73  ? -9.529  -11.524 35.908 1.000 52.761  0 73  GLU B CA  1 ? 
ATOM   2049 C C   . GLU B 1 73  ? -10.972 -11.552 36.409 1.000 51.909  0 73  GLU B C   1 ? 
ATOM   2050 O O   . GLU B 1 73  ? -11.733 -12.430 36.017 1.000 57.232  0 73  GLU B O   1 ? 
ATOM   2051 C CB  . GLU B 1 73  ? -8.659  -12.523 36.676 1.000 55.163  0 73  GLU B CB  1 ? 
ATOM   2052 N N   . LYS B 1 74  ? -11.348 -10.605 37.277 1.000 46.481  0 74  LYS B N   1 ? 
ATOM   2053 C CA  . LYS B 1 74  ? -12.728 -10.466 37.725 1.000 44.652  0 74  LYS B CA  1 ? 
ATOM   2054 C C   . LYS B 1 74  ? -13.515 -9.576  36.756 1.000 43.568  0 74  LYS B C   1 ? 
ATOM   2055 O O   . LYS B 1 74  ? -14.713 -9.391  36.921 1.000 51.258  0 74  LYS B O   1 ? 
ATOM   2056 C CB  . LYS B 1 74  ? -12.767 -9.942  39.168 1.000 37.862  0 74  LYS B CB  1 ? 
ATOM   2057 N N   . GLY B 1 75  ? -12.861 -9.043  35.724 1.000 45.272  0 75  GLY B N   1 ? 
ATOM   2058 C CA  . GLY B 1 75  ? -13.495 -8.148  34.762 1.000 52.552  0 75  GLY B CA  1 ? 
ATOM   2059 C C   . GLY B 1 75  ? -14.022 -6.846  35.383 1.000 55.474  0 75  GLY B C   1 ? 
ATOM   2060 O O   . GLY B 1 75  ? -15.128 -6.395  35.067 1.000 68.708  0 75  GLY B O   1 ? 
ATOM   2061 N N   . GLU B 1 76  ? -13.226 -6.250  36.277 1.000 53.388  0 76  GLU B N   1 ? 
ATOM   2062 C CA  . GLU B 1 76  ? -13.640 -5.073  37.025 1.000 51.661  0 76  GLU B CA  1 ? 
ATOM   2063 C C   . GLU B 1 76  ? -12.498 -4.058  37.152 1.000 51.285  0 76  GLU B C   1 ? 
ATOM   2064 O O   . GLU B 1 76  ? -12.525 -3.253  38.081 1.000 54.179  0 76  GLU B O   1 ? 
ATOM   2065 C CB  . GLU B 1 76  ? -14.108 -5.481  38.428 1.000 56.736  0 76  GLU B CB  1 ? 
ATOM   2066 C CG  . GLU B 1 76  ? -14.807 -6.831  38.484 1.000 71.140  0 76  GLU B CG  1 ? 
ATOM   2067 C CD  . GLU B 1 76  ? -15.532 -7.173  39.780 1.000 77.066  0 76  GLU B CD  1 ? 
ATOM   2068 O OE1 . GLU B 1 76  ? -15.450 -6.369  40.744 1.000 73.196  0 76  GLU B OE1 1 ? 
ATOM   2069 O OE2 . GLU B 1 76  ? -16.200 -8.246  39.813 1.000 75.582  0 76  GLU B OE2 1 ? 
ATOM   2070 N N   . LEU B 1 77  ? -11.512 -4.075  36.237 1.000 45.306  0 77  LEU B N   1 ? 
ATOM   2071 C CA  . LEU B 1 77  ? -10.337 -3.217  36.349 1.000 42.500  0 77  LEU B CA  1 ? 
ATOM   2072 C C   . LEU B 1 77  ? -10.641 -1.793  35.884 1.000 43.322  0 77  LEU B C   1 ? 
ATOM   2073 O O   . LEU B 1 77  ? -10.275 -0.842  36.548 1.000 43.477  0 77  LEU B O   1 ? 
ATOM   2074 C CB  . LEU B 1 77  ? -9.202  -3.813  35.524 1.000 40.549  0 77  LEU B CB  1 ? 
ATOM   2075 C CG  . LEU B 1 77  ? -7.934  -2.972  35.450 1.000 40.508  0 77  LEU B CG  1 ? 
ATOM   2076 C CD1 . LEU B 1 77  ? -7.279  -2.850  36.803 1.000 40.000  0 77  LEU B CD1 1 ? 
ATOM   2077 C CD2 . LEU B 1 77  ? -6.953  -3.595  34.468 1.000 47.755  0 77  LEU B CD2 1 ? 
ATOM   2078 N N   . SER B 1 78  ? -11.308 -1.649  34.741 1.000 46.469  0 78  SER B N   1 ? 
ATOM   2079 C CA  . SER B 1 78  ? -11.744 -0.346  34.250 1.000 44.778  0 78  SER B CA  1 ? 
ATOM   2080 C C   . SER B 1 78  ? -12.428 0.469   35.329 1.000 41.982  0 78  SER B C   1 ? 
ATOM   2081 O O   . SER B 1 78  ? -12.322 1.685   35.305 1.000 44.714  0 78  SER B O   1 ? 
ATOM   2082 C CB  . SER B 1 78  ? -12.691 -0.472  33.097 1.000 45.426  0 78  SER B CB  1 ? 
ATOM   2083 O OG  . SER B 1 78  ? -11.979 -0.633  31.894 1.000 49.423  0 78  SER B OG  1 ? 
ATOM   2084 N N   . THR B 1 79  ? -13.162 -0.199  36.222 1.000 45.892  0 79  THR B N   1 ? 
ATOM   2085 C CA  . THR B 1 79  ? -14.058 0.514   37.125 1.000 53.671  0 79  THR B CA  1 ? 
ATOM   2086 C C   . THR B 1 79  ? -13.473 0.670   38.532 1.000 48.270  0 79  THR B C   1 ? 
ATOM   2087 O O   . THR B 1 79  ? -14.026 1.429   39.313 1.000 46.298  0 79  THR B O   1 ? 
ATOM   2088 C CB  . THR B 1 79  ? -15.456 -0.129  37.147 1.000 55.798  0 79  THR B CB  1 ? 
ATOM   2089 O OG1 . THR B 1 79  ? -15.379 -1.490  37.568 1.000 57.215  0 79  THR B OG1 1 ? 
ATOM   2090 C CG2 . THR B 1 79  ? -16.128 -0.094  35.790 1.000 56.567  0 79  THR B CG2 1 ? 
ATOM   2091 N N   . ARG B 1 80  ? -12.369 -0.026  38.864 1.000 47.448  0 80  ARG B N   1 ? 
ATOM   2092 C CA  . ARG B 1 80  ? -11.845 -0.003  40.231 1.000 44.841  0 80  ARG B CA  1 ? 
ATOM   2093 C C   . ARG B 1 80  ? -10.324 0.161   40.247 1.000 40.290  0 80  ARG B C   1 ? 
ATOM   2094 O O   . ARG B 1 80  ? -9.675  -0.068  41.271 1.000 40.324  0 80  ARG B O   1 ? 
ATOM   2095 C CB  . ARG B 1 80  ? -12.190 -1.299  40.977 1.000 46.553  0 80  ARG B CB  1 ? 
ATOM   2096 C CG  . ARG B 1 80  ? -13.664 -1.676  41.013 1.000 48.680  0 80  ARG B CG  1 ? 
ATOM   2097 C CD  . ARG B 1 80  ? -13.874 -2.967  41.788 1.000 50.894  0 80  ARG B CD  1 ? 
ATOM   2098 N NE  . ARG B 1 80  ? -13.451 -2.785  43.173 1.000 48.842  0 80  ARG B NE  1 ? 
ATOM   2099 C CZ  . ARG B 1 80  ? -13.154 -3.757  44.025 1.000 48.429  0 80  ARG B CZ  1 ? 
ATOM   2100 N NH1 . ARG B 1 80  ? -13.476 -5.006  43.759 1.000 49.666  0 80  ARG B NH1 1 ? 
ATOM   2101 N NH2 . ARG B 1 80  ? -12.505 -3.479  45.142 1.000 50.789  0 80  ARG B NH2 1 ? 
ATOM   2102 N N   . LEU B 1 81  ? -9.752  0.570   39.113 1.000 36.204  0 81  LEU B N   1 ? 
ATOM   2103 C CA  . LEU B 1 81  ? -8.315  0.704   38.975 1.000 35.104  0 81  LEU B CA  1 ? 
ATOM   2104 C C   . LEU B 1 81  ? -7.729  1.615   40.047 1.000 38.353  0 81  LEU B C   1 ? 
ATOM   2105 O O   . LEU B 1 81  ? -6.619  1.373   40.506 1.000 38.795  0 81  LEU B O   1 ? 
ATOM   2106 C CB  . LEU B 1 81  ? -8.041  1.285   37.597 1.000 36.392  0 81  LEU B CB  1 ? 
ATOM   2107 C CG  . LEU B 1 81  ? -6.597  1.636   37.305 1.000 38.560  0 81  LEU B CG  1 ? 
ATOM   2108 C CD1 . LEU B 1 81  ? -5.792  0.383   37.053 1.000 37.165  0 81  LEU B CD1 1 ? 
ATOM   2109 C CD2 . LEU B 1 81  ? -6.556  2.568   36.109 1.000 44.286  0 81  LEU B CD2 1 ? 
ATOM   2110 N N   . GLY B 1 82  ? -8.450  2.686   40.406 1.000 44.619  0 82  GLY B N   1 ? 
ATOM   2111 C CA  . GLY B 1 82  ? -7.992  3.635   41.412 1.000 43.562  0 82  GLY B CA  1 ? 
ATOM   2112 C C   . GLY B 1 82  ? -7.986  3.035   42.812 1.000 44.562  0 82  GLY B C   1 ? 
ATOM   2113 O O   . GLY B 1 82  ? -7.278  3.544   43.682 1.000 46.156  0 82  GLY B O   1 ? 
ATOM   2114 N N   . GLU B 1 83  ? -8.793  1.978   43.013 1.000 44.806  0 83  GLU B N   1 ? 
ATOM   2115 C CA  . GLU B 1 83  ? -8.657  1.114   44.182 1.000 50.242  0 83  GLU B CA  1 ? 
ATOM   2116 C C   . GLU B 1 83  ? -7.238  0.547   44.274 1.000 43.140  0 83  GLU B C   1 ? 
ATOM   2117 O O   . GLU B 1 83  ? -6.623  0.645   45.328 1.000 45.548  0 83  GLU B O   1 ? 
ATOM   2118 C CB  . GLU B 1 83  ? -9.731  0.022   44.216 1.000 53.398  0 83  GLU B CB  1 ? 
ATOM   2119 C CG  . GLU B 1 83  ? -10.998 0.481   44.937 1.000 60.577  0 83  GLU B CG  1 ? 
ATOM   2120 C CD  . GLU B 1 83  ? -12.366 0.182   44.316 1.000 64.660  0 83  GLU B CD  1 ? 
ATOM   2121 O OE1 . GLU B 1 83  ? -12.823 0.938   43.412 1.000 77.824  0 83  GLU B OE1 1 ? 
ATOM   2122 O OE2 . GLU B 1 83  ? -12.993 -0.786  44.749 1.000 59.774  0 83  GLU B OE2 1 ? 
ATOM   2123 N N   . ALA B 1 84  ? -6.694  0.003   43.180 1.000 38.020  0 84  ALA B N   1 ? 
ATOM   2124 C CA  . ALA B 1 84  ? -5.348  -0.570  43.202 1.000 34.662  0 84  ALA B CA  1 ? 
ATOM   2125 C C   . ALA B 1 84  ? -4.298  0.487   43.551 1.000 33.142  0 84  ALA B C   1 ? 
ATOM   2126 O O   . ALA B 1 84  ? -3.336  0.219   44.270 1.000 33.828  0 84  ALA B O   1 ? 
ATOM   2127 C CB  . ALA B 1 84  ? -5.053  -1.213  41.872 1.000 34.287  0 84  ALA B CB  1 ? 
ATOM   2128 N N   . PHE B 1 85  ? -4.503  1.700   43.042 1.000 33.423  0 85  PHE B N   1 ? 
ATOM   2129 C CA  . PHE B 1 85  ? -3.564  2.781   43.225 1.000 34.269  0 85  PHE B CA  1 ? 
ATOM   2130 C C   . PHE B 1 85  ? -3.563  3.281   44.668 1.000 35.527  0 85  PHE B C   1 ? 
ATOM   2131 O O   . PHE B 1 85  ? -2.568  3.814   45.135 1.000 35.497  0 85  PHE B O   1 ? 
ATOM   2132 C CB  . PHE B 1 85  ? -3.875  3.893   42.228 1.000 35.624  0 85  PHE B CB  1 ? 
ATOM   2133 C CG  . PHE B 1 85  ? -3.148  3.736   40.918 1.000 37.885  0 85  PHE B CG  1 ? 
ATOM   2134 C CD1 . PHE B 1 85  ? -1.821  4.103   40.802 1.000 36.439  0 85  PHE B CD1 1 ? 
ATOM   2135 C CD2 . PHE B 1 85  ? -3.790  3.248   39.801 1.000 42.039  0 85  PHE B CD2 1 ? 
ATOM   2136 C CE1 . PHE B 1 85  ? -1.159  3.994   39.599 1.000 38.506  0 85  PHE B CE1 1 ? 
ATOM   2137 C CE2 . PHE B 1 85  ? -3.127  3.142   38.592 1.000 41.683  0 85  PHE B CE2 1 ? 
ATOM   2138 C CZ  . PHE B 1 85  ? -1.806  3.488   38.504 1.000 41.396  0 85  PHE B CZ  1 ? 
ATOM   2139 N N   . SER B 1 86  ? -4.653  3.078   45.406 1.000 40.670  0 86  SER B N   1 ? 
ATOM   2140 C CA  . SER B 1 86  ? -4.754  3.684   46.726 1.000 35.530  0 86  SER B CA  1 ? 
ATOM   2141 C C   . SER B 1 86  ? -3.832  2.972   47.702 1.000 37.834  0 86  SER B C   1 ? 
ATOM   2142 O O   . SER B 1 86  ? -3.397  3.594   48.668 1.000 41.449  0 86  SER B O   1 ? 
ATOM   2143 C CB  . SER B 1 86  ? -6.177  3.715   47.221 1.000 38.980  0 86  SER B CB  1 ? 
ATOM   2144 O OG  . SER B 1 86  ? -6.761  2.414   47.197 1.000 39.326  0 86  SER B OG  1 ? 
ATOM   2145 N N   . GLN B 1 87  ? -3.509  1.693   47.443 1.000 34.228  0 87  GLN B N   1 ? 
ATOM   2146 C CA  . GLN B 1 87  ? -2.505  1.005   48.239 1.000 38.051  0 87  GLN B CA  1 ? 
ATOM   2147 C C   . GLN B 1 87  ? -1.121  1.452   47.802 1.000 35.322  0 87  GLN B C   1 ? 
ATOM   2148 O O   . GLN B 1 87  ? -0.219  1.531   48.620 1.000 36.400  0 87  GLN B O   1 ? 
ATOM   2149 C CB  . GLN B 1 87  ? -2.550  -0.521  48.121 1.000 45.707  0 87  GLN B CB  1 ? 
ATOM   2150 C CG  . GLN B 1 87  ? -3.951  -1.103  48.215 1.000 54.774  0 87  GLN B CG  1 ? 
ATOM   2151 C CD  . GLN B 1 87  ? -3.994  -2.528  48.707 1.000 76.523  0 87  GLN B CD  1 ? 
ATOM   2152 O OE1 . GLN B 1 87  ? -5.067  -3.086  48.932 1.000 93.105  0 87  GLN B OE1 1 ? 
ATOM   2153 N NE2 . GLN B 1 87  ? -2.831  -3.135  48.893 1.000 82.525  0 87  GLN B NE2 1 ? 
ATOM   2154 N N   . PHE B 1 88  ? -0.966  1.717   46.504 1.000 35.461  0 88  PHE B N   1 ? 
ATOM   2155 C CA  . PHE B 1 88  ? 0.331   1.989   45.917 1.000 33.547  0 88  PHE B CA  1 ? 
ATOM   2156 C C   . PHE B 1 88  ? 0.805   3.394   46.268 1.000 36.036  0 88  PHE B C   1 ? 
ATOM   2157 O O   . PHE B 1 88  ? 1.921   3.545   46.758 1.000 35.100  0 88  PHE B O   1 ? 
ATOM   2158 C CB  . PHE B 1 88  ? 0.241   1.818   44.406 1.000 32.751  0 88  PHE B CB  1 ? 
ATOM   2159 C CG  . PHE B 1 88  ? 1.479   2.114   43.595 1.000 34.208  0 88  PHE B CG  1 ? 
ATOM   2160 C CD1 . PHE B 1 88  ? 2.586   1.289   43.655 1.000 34.188  0 88  PHE B CD1 1 ? 
ATOM   2161 C CD2 . PHE B 1 88  ? 1.509   3.176   42.701 1.000 35.381  0 88  PHE B CD2 1 ? 
ATOM   2162 C CE1 . PHE B 1 88  ? 3.694   1.540   42.859 1.000 34.430  0 88  PHE B CE1 1 ? 
ATOM   2163 C CE2 . PHE B 1 88  ? 2.614   3.419   41.906 1.000 33.226  0 88  PHE B CE2 1 ? 
ATOM   2164 C CZ  . PHE B 1 88  ? 3.716   2.616   42.005 1.000 32.409  0 88  PHE B CZ  1 ? 
ATOM   2165 N N   . ILE B 1 89  ? -0.039  4.405   46.022 1.000 37.151  0 89  ILE B N   1 ? 
ATOM   2166 C CA  . ILE B 1 89  ? 0.408   5.791   45.993 1.000 41.498  0 89  ILE B CA  1 ? 
ATOM   2167 C C   . ILE B 1 89  ? 1.103   6.117   47.310 1.000 39.039  0 89  ILE B C   1 ? 
ATOM   2168 O O   . ILE B 1 89  ? 2.081   6.843   47.346 1.000 38.426  0 89  ILE B O   1 ? 
ATOM   2169 C CB  . ILE B 1 89  ? -0.741  6.806   45.802 1.000 53.451  0 89  ILE B CB  1 ? 
ATOM   2170 C CG1 . ILE B 1 89  ? -1.709  6.527   44.659 1.000 55.796  0 89  ILE B CG1 1 ? 
ATOM   2171 C CG2 . ILE B 1 89  ? -0.187  8.204   45.653 1.000 61.608  0 89  ILE B CG2 1 ? 
ATOM   2172 C CD1 . ILE B 1 89  ? -3.134  6.895   45.053 1.000 60.057  0 89  ILE B CD1 1 ? 
ATOM   2173 N N   . PRO B 1 90  ? 0.616   5.661   48.475 1.000 40.433  0 90  PRO B N   1 ? 
ATOM   2174 C CA  . PRO B 1 90  ? 1.238   6.101   49.716 1.000 40.392  0 90  PRO B CA  1 ? 
ATOM   2175 C C   . PRO B 1 90  ? 2.541   5.359   50.025 1.000 42.310  0 90  PRO B C   1 ? 
ATOM   2176 O O   . PRO B 1 90  ? 3.251   5.734   50.957 1.000 40.447  0 90  PRO B O   1 ? 
ATOM   2177 C CB  . PRO B 1 90  ? 0.117   5.901   50.753 1.000 39.596  0 90  PRO B CB  1 ? 
ATOM   2178 C CG  . PRO B 1 90  ? -0.908  4.962   50.133 1.000 37.037  0 90  PRO B CG  1 ? 
ATOM   2179 C CD  . PRO B 1 90  ? -0.546  4.791   48.676 1.000 37.553  0 90  PRO B CD  1 ? 
ATOM   2180 N N   . MET B 1 91  ? 2.884   4.335   49.221 1.000 42.148  0 91  MET B N   1 ? 
ATOM   2181 C CA  . MET B 1 91  ? 4.171   3.650   49.348 1.000 46.447  0 91  MET B CA  1 ? 
ATOM   2182 C C   . MET B 1 91  ? 5.277   4.329   48.536 1.000 38.201  0 91  MET B C   1 ? 
ATOM   2183 O O   . MET B 1 91  ? 6.397   3.847   48.569 1.000 32.907  0 91  MET B O   1 ? 
ATOM   2184 C CB  . MET B 1 91  ? 4.073   2.199   48.861 1.000 51.943  0 91  MET B CB  1 ? 
ATOM   2185 C CG  . MET B 1 91  ? 3.003   1.396   49.576 1.000 52.851  0 91  MET B CG  1 ? 
ATOM   2186 S SD  . MET B 1 91  ? 3.113   1.489   51.398 1.000 60.494  0 91  MET B SD  1 ? 
ATOM   2187 C CE  . MET B 1 91  ? 3.465   -0.235  51.762 1.000 55.656  0 91  MET B CE  1 ? 
ATOM   2188 N N   . MET B 1 92  ? 4.947   5.445   47.860 1.000 38.024  0 92  MET B N   1 ? 
ATOM   2189 C CA  . MET B 1 92  ? 5.766   6.129   46.866 1.000 40.618  0 92  MET B CA  1 ? 
ATOM   2190 C C   . MET B 1 92  ? 7.132   6.580   47.390 1.000 42.297  0 92  MET B C   1 ? 
ATOM   2191 O O   . MET B 1 92  ? 8.067   6.694   46.607 1.000 49.065  0 92  MET B O   1 ? 
ATOM   2192 C CB  . MET B 1 92  ? 5.030   7.383   46.370 1.000 51.700  0 92  MET B CB  1 ? 
ATOM   2193 C CG  . MET B 1 92  ? 5.178   7.699   44.879 1.000 55.161  0 92  MET B CG  1 ? 
ATOM   2194 S SD  . MET B 1 92  ? 4.054   6.873   43.703 1.000 53.884  0 92  MET B SD  1 ? 
ATOM   2195 C CE  . MET B 1 92  ? 3.933   5.222   44.384 1.000 57.665  0 92  MET B CE  1 ? 
ATOM   2196 N N   . ASN B 1 93  ? 7.270   6.891   48.682 1.000 41.089  0 93  ASN B N   1 ? 
ATOM   2197 C CA  . ASN B 1 93  ? 8.511   7.449   49.208 1.000 39.988  0 93  ASN B CA  1 ? 
ATOM   2198 C C   . ASN B 1 93  ? 9.709   6.598   48.777 1.000 34.216  0 93  ASN B C   1 ? 
ATOM   2199 O O   . ASN B 1 93  ? 10.848  7.063   48.731 1.000 32.533  0 93  ASN B O   1 ? 
ATOM   2200 C CB  . ASN B 1 93  ? 8.466   7.570   50.742 1.000 46.466  0 93  ASN B CB  1 ? 
ATOM   2201 C CG  . ASN B 1 93  ? 9.642   8.328   51.332 1.000 54.659  0 93  ASN B CG  1 ? 
ATOM   2202 O OD1 . ASN B 1 93  ? 10.558  7.714   51.873 1.000 56.171  0 93  ASN B OD1 1 ? 
ATOM   2203 N ND2 . ASN B 1 93  ? 9.656   9.650   51.196 1.000 58.814  0 93  ASN B ND2 1 ? 
ATOM   2204 N N   . VAL B 1 94  ? 9.450   5.318   48.523 1.000 30.154  0 94  VAL B N   1 ? 
ATOM   2205 C CA  . VAL B 1 94  ? 10.395  4.385   47.945 1.000 29.284  0 94  VAL B CA  1 ? 
ATOM   2206 C C   . VAL B 1 94  ? 10.968  4.928   46.639 1.000 26.660  0 94  VAL B C   1 ? 
ATOM   2207 O O   . VAL B 1 94  ? 12.157  4.813   46.334 1.000 29.413  0 94  VAL B O   1 ? 
ATOM   2208 C CB  . VAL B 1 94  ? 9.604   3.085   47.746 1.000 32.063  0 94  VAL B CB  1 ? 
ATOM   2209 C CG1 . VAL B 1 94  ? 10.063  2.306   46.535 1.000 35.372  0 94  VAL B CG1 1 ? 
ATOM   2210 C CG2 . VAL B 1 94  ? 9.630   2.252   49.021 1.000 32.983  0 94  VAL B CG2 1 ? 
ATOM   2211 N N   . TYR B 1 95  ? 10.083  5.481   45.830 1.000 26.391  0 95  TYR B N   1 ? 
ATOM   2212 C CA  . TYR B 1 95  ? 10.496  6.116   44.593 1.000 31.421  0 95  TYR B CA  1 ? 
ATOM   2213 C C   . TYR B 1 95  ? 11.386  7.324   44.887 1.000 31.759  0 95  TYR B C   1 ? 
ATOM   2214 O O   . TYR B 1 95  ? 12.328  7.567   44.147 1.000 33.043  0 95  TYR B O   1 ? 
ATOM   2215 C CB  . TYR B 1 95  ? 9.284   6.493   43.727 1.000 30.786  0 95  TYR B CB  1 ? 
ATOM   2216 C CG  . TYR B 1 95  ? 8.775   5.414   42.804 1.000 30.951  0 95  TYR B CG  1 ? 
ATOM   2217 C CD1 . TYR B 1 95  ? 7.801   4.505   43.206 1.000 29.343  0 95  TYR B CD1 1 ? 
ATOM   2218 C CD2 . TYR B 1 95  ? 9.249   5.323   41.500 1.000 29.681  0 95  TYR B CD2 1 ? 
ATOM   2219 C CE1 . TYR B 1 95  ? 7.331   3.522   42.339 1.000 28.141  0 95  TYR B CE1 1 ? 
ATOM   2220 C CE2 . TYR B 1 95  ? 8.789   4.355   40.625 1.000 30.167  0 95  TYR B CE2 1 ? 
ATOM   2221 C CZ  . TYR B 1 95  ? 7.839   3.441   41.052 1.000 28.513  0 95  TYR B CZ  1 ? 
ATOM   2222 O OH  . TYR B 1 95  ? 7.419   2.477   40.175 1.000 31.455  0 95  TYR B OH  1 ? 
ATOM   2223 N N   . LYS B 1 96  ? 11.086  8.088   45.946 1.000 34.827  0 96  LYS B N   1 ? 
ATOM   2224 C CA  . LYS B 1 96  ? 11.919  9.230   46.332 1.000 42.560  0 96  LYS B CA  1 ? 
ATOM   2225 C C   . LYS B 1 96  ? 13.345  8.777   46.631 1.000 40.010  0 96  LYS B C   1 ? 
ATOM   2226 O O   . LYS B 1 96  ? 14.305  9.411   46.186 1.000 36.534  0 96  LYS B O   1 ? 
ATOM   2227 C CB  . LYS B 1 96  ? 11.388  9.976   47.564 1.000 43.126  0 96  LYS B CB  1 ? 
ATOM   2228 C CG  . LYS B 1 96  ? 11.113  11.451  47.317 1.000 46.844  0 96  LYS B CG  1 ? 
ATOM   2229 C CD  . LYS B 1 96  ? 11.156  12.311  48.580 1.000 54.919  0 96  LYS B CD  1 ? 
ATOM   2230 N N   . LEU B 1 97  ? 13.451  7.692   47.407 1.000 35.900  0 97  LEU B N   1 ? 
ATOM   2231 C CA  . LEU B 1 97  ? 14.738  7.161   47.820 1.000 32.339  0 97  LEU B CA  1 ? 
ATOM   2232 C C   . LEU B 1 97  ? 15.483  6.635   46.612 1.000 30.567  0 97  LEU B C   1 ? 
ATOM   2233 O O   . LEU B 1 97  ? 16.693  6.836   46.488 1.000 32.948  0 97  LEU B O   1 ? 
ATOM   2234 C CB  . LEU B 1 97  ? 14.526  6.046   48.842 1.000 32.667  0 97  LEU B CB  1 ? 
ATOM   2235 C CG  . LEU B 1 97  ? 13.838  6.508   50.122 1.000 33.383  0 97  LEU B CG  1 ? 
ATOM   2236 C CD1 . LEU B 1 97  ? 13.504  5.305   51.009 1.000 33.049  0 97  LEU B CD1 1 ? 
ATOM   2237 C CD2 . LEU B 1 97  ? 14.723  7.518   50.838 1.000 30.424  0 97  LEU B CD2 1 ? 
ATOM   2238 N N   . PHE B 1 98  ? 14.764  5.968   45.718 1.000 30.109  0 98  PHE B N   1 ? 
ATOM   2239 C CA  . PHE B 1 98  ? 15.434  5.446   44.538 1.000 34.786  0 98  PHE B CA  1 ? 
ATOM   2240 C C   . PHE B 1 98  ? 15.957  6.601   43.671 1.000 33.310  0 98  PHE B C   1 ? 
ATOM   2241 O O   . PHE B 1 98  ? 17.148  6.682   43.371 1.000 35.370  0 98  PHE B O   1 ? 
ATOM   2242 C CB  . PHE B 1 98  ? 14.508  4.490   43.794 1.000 33.610  0 98  PHE B CB  1 ? 
ATOM   2243 C CG  . PHE B 1 98  ? 15.177  3.879   42.601 1.000 32.570  0 98  PHE B CG  1 ? 
ATOM   2244 C CD1 . PHE B 1 98  ? 16.013  2.780   42.741 1.000 33.456  0 98  PHE B CD1 1 ? 
ATOM   2245 C CD2 . PHE B 1 98  ? 15.010  4.434   41.339 1.000 31.770  0 98  PHE B CD2 1 ? 
ATOM   2246 C CE1 . PHE B 1 98  ? 16.669  2.247   41.635 1.000 32.930  0 98  PHE B CE1 1 ? 
ATOM   2247 C CE2 . PHE B 1 98  ? 15.647  3.880   40.238 1.000 31.460  0 98  PHE B CE2 1 ? 
ATOM   2248 C CZ  . PHE B 1 98  ? 16.476  2.782   40.384 1.000 29.748  0 98  PHE B CZ  1 ? 
ATOM   2249 N N   . LEU B 1 99  ? 15.058  7.505   43.280 1.000 32.778  0 99  LEU B N   1 ? 
ATOM   2250 C CA  . LEU B 1 99  ? 15.426  8.723   42.578 1.000 33.769  0 99  LEU B CA  1 ? 
ATOM   2251 C C   . LEU B 1 99  ? 16.605  9.391   43.272 1.000 30.123  0 99  LEU B C   1 ? 
ATOM   2252 O O   . LEU B 1 99  ? 17.589  9.758   42.641 1.000 34.458  0 99  LEU B O   1 ? 
ATOM   2253 C CB  . LEU B 1 99  ? 14.234  9.682   42.565 1.000 40.635  0 99  LEU B CB  1 ? 
ATOM   2254 C CG  . LEU B 1 99  ? 13.378  9.665   41.305 1.000 45.563  0 99  LEU B CG  1 ? 
ATOM   2255 C CD1 . LEU B 1 99  ? 13.040  8.238   40.882 1.000 45.534  0 99  LEU B CD1 1 ? 
ATOM   2256 C CD2 . LEU B 1 99  ? 12.108  10.479  41.532 1.000 48.766  0 99  LEU B CD2 1 ? 
ATOM   2257 N N   . GLY B 1 100 ? 16.511  9.493   44.584 1.000 26.325  0 100 GLY B N   1 ? 
ATOM   2258 C CA  . GLY B 1 100 ? 17.504  10.206  45.352 1.000 28.911  0 100 GLY B CA  1 ? 
ATOM   2259 C C   . GLY B 1 100 ? 18.888  9.566   45.270 1.000 30.102  0 100 GLY B C   1 ? 
ATOM   2260 O O   . GLY B 1 100 ? 19.888  10.178  45.612 1.000 28.126  0 100 GLY B O   1 ? 
ATOM   2261 N N   . ASN B 1 101 ? 18.938  8.301   44.885 1.000 35.606  0 101 ASN B N   1 ? 
ATOM   2262 C CA  . ASN B 1 101 ? 20.195  7.595   44.840 1.000 34.900  0 101 ASN B CA  1 ? 
ATOM   2263 C C   . ASN B 1 101 ? 20.732  7.589   43.398 1.000 38.295  0 101 ASN B C   1 ? 
ATOM   2264 O O   . ASN B 1 101 ? 21.816  7.081   43.158 1.000 42.743  0 101 ASN B O   1 ? 
ATOM   2265 C CB  . ASN B 1 101 ? 20.012  6.195   45.425 1.000 34.740  0 101 ASN B CB  1 ? 
ATOM   2266 C CG  . ASN B 1 101 ? 21.341  5.503   45.625 1.000 35.930  0 101 ASN B CG  1 ? 
ATOM   2267 O OD1 . ASN B 1 101 ? 22.190  6.012   46.363 1.000 34.969  0 101 ASN B OD1 1 ? 
ATOM   2268 N ND2 . ASN B 1 101 ? 21.539  4.385   44.936 1.000 33.456  0 101 ASN B ND2 1 ? 
ATOM   2269 N N   . SER B 1 102 ? 20.007  8.130   42.417 1.000 36.619  0 102 SER B N   1 ? 
ATOM   2270 C CA  . SER B 1 102 ? 20.398  7.856   41.043 1.000 40.114  0 102 SER B CA  1 ? 
ATOM   2271 C C   . SER B 1 102 ? 21.768  8.444   40.690 1.000 40.402  0 102 SER B C   1 ? 
ATOM   2272 O O   . SER B 1 102 ? 22.549  7.805   39.994 1.000 36.448  0 102 SER B O   1 ? 
ATOM   2273 C CB  . SER B 1 102 ? 19.362  8.305   40.091 1.000 41.443  0 102 SER B CB  1 ? 
ATOM   2274 O OG  . SER B 1 102 ? 19.494  7.560   38.888 1.000 49.952  0 102 SER B OG  1 ? 
ATOM   2275 N N   . ASP B 1 103 ? 22.058  9.657   41.170 1.000 42.897  0 103 ASP B N   1 ? 
ATOM   2276 C CA  . ASP B 1 103 ? 23.340  10.315  40.955 1.000 47.810  0 103 ASP B CA  1 ? 
ATOM   2277 C C   . ASP B 1 103 ? 24.480  9.437   41.473 1.000 43.297  0 103 ASP B C   1 ? 
ATOM   2278 O O   . ASP B 1 103 ? 25.438  9.190   40.757 1.000 49.184  0 103 ASP B O   1 ? 
ATOM   2279 C CB  . ASP B 1 103 ? 23.337  11.687  41.648 1.000 65.081  0 103 ASP B CB  1 ? 
ATOM   2280 C CG  . ASP B 1 103 ? 24.532  12.603  41.406 1.000 79.312  0 103 ASP B CG  1 ? 
ATOM   2281 O OD1 . ASP B 1 103 ? 24.572  13.265  40.352 1.000 96.293  0 103 ASP B OD1 1 ? 
ATOM   2282 O OD2 . ASP B 1 103 ? 25.395  12.693  42.299 1.000 90.360  0 103 ASP B OD2 1 ? 
ATOM   2283 N N   . THR B 1 104 ? 24.379  8.993   42.730 1.000 33.577  0 104 THR B N   1 ? 
ATOM   2284 C CA  . THR B 1 104 ? 25.327  8.072   43.324 1.000 31.841  0 104 THR B CA  1 ? 
ATOM   2285 C C   . THR B 1 104 ? 25.396  6.752   42.560 1.000 33.487  0 104 THR B C   1 ? 
ATOM   2286 O O   . THR B 1 104 ? 26.466  6.279   42.240 1.000 39.128  0 104 THR B O   1 ? 
ATOM   2287 C CB  . THR B 1 104 ? 24.930  7.764   44.769 1.000 33.508  0 104 THR B CB  1 ? 
ATOM   2288 O OG1 . THR B 1 104 ? 24.908  8.997   45.474 1.000 34.789  0 104 THR B OG1 1 ? 
ATOM   2289 C CG2 . THR B 1 104 ? 25.867  6.797   45.457 1.000 33.268  0 104 THR B CG2 1 ? 
ATOM   2290 N N   . SER B 1 105 ? 24.258  6.113   42.322 1.000 34.717  0 105 SER B N   1 ? 
ATOM   2291 C CA  . SER B 1 105 ? 24.231  4.834   41.643 1.000 33.501  0 105 SER B CA  1 ? 
ATOM   2292 C C   . SER B 1 105 ? 25.037  4.944   40.354 1.000 36.730  0 105 SER B C   1 ? 
ATOM   2293 O O   . SER B 1 105 ? 25.884  4.097   40.088 1.000 32.934  0 105 SER B O   1 ? 
ATOM   2294 C CB  . SER B 1 105 ? 22.830  4.405   41.354 1.000 31.171  0 105 SER B CB  1 ? 
ATOM   2295 O OG  . SER B 1 105 ? 22.807  3.243   40.544 1.000 30.734  0 105 SER B OG  1 ? 
ATOM   2296 N N   . LEU B 1 106 ? 24.799  6.010   39.576 1.000 37.540  0 106 LEU B N   1 ? 
ATOM   2297 C CA  . LEU B 1 106 ? 25.443  6.136   38.279 1.000 37.390  0 106 LEU B CA  1 ? 
ATOM   2298 C C   . LEU B 1 106 ? 26.929  6.417   38.443 1.000 37.965  0 106 LEU B C   1 ? 
ATOM   2299 O O   . LEU B 1 106 ? 27.730  5.949   37.635 1.000 38.216  0 106 LEU B O   1 ? 
ATOM   2300 C CB  . LEU B 1 106 ? 24.808  7.242   37.443 1.000 41.449  0 106 LEU B CB  1 ? 
ATOM   2301 C CG  . LEU B 1 106 ? 25.389  7.362   36.031 1.000 51.257  0 106 LEU B CG  1 ? 
ATOM   2302 C CD1 . LEU B 1 106 ? 25.202  6.061   35.252 1.000 56.860  0 106 LEU B CD1 1 ? 
ATOM   2303 C CD2 . LEU B 1 106 ? 24.759  8.526   35.257 1.000 55.053  0 106 LEU B CD2 1 ? 
ATOM   2304 N N   . GLN B 1 107 ? 27.297  7.210   39.455 1.000 32.289  0 107 GLN B N   1 ? 
ATOM   2305 C CA  . GLN B 1 107 ? 28.698  7.489   39.689 1.000 33.966  0 107 GLN B CA  1 ? 
ATOM   2306 C C   . GLN B 1 107 ? 29.438  6.176   39.989 1.000 34.051  0 107 GLN B C   1 ? 
ATOM   2307 O O   . GLN B 1 107 ? 30.558  5.940   39.513 1.000 29.662  0 107 GLN B O   1 ? 
ATOM   2308 C CB  . GLN B 1 107 ? 28.828  8.530   40.802 1.000 39.417  0 107 GLN B CB  1 ? 
ATOM   2309 C CG  . GLN B 1 107 ? 30.260  8.943   41.124 1.000 44.967  0 107 GLN B CG  1 ? 
ATOM   2310 C CD  . GLN B 1 107 ? 31.006  9.447   39.910 1.000 57.221  0 107 GLN B CD  1 ? 
ATOM   2311 O OE1 . GLN B 1 107 ? 30.458  10.198  39.104 1.000 56.557  0 107 GLN B OE1 1 ? 
ATOM   2312 N NE2 . GLN B 1 107 ? 32.252  9.005   39.749 1.000 66.622  0 107 GLN B NE2 1 ? 
ATOM   2313 N N   . PHE B 1 108 ? 28.815  5.293   40.768 1.000 31.170  0 108 PHE B N   1 ? 
ATOM   2314 C CA  . PHE B 1 108 ? 29.469  4.029   41.067 1.000 33.897  0 108 PHE B CA  1 ? 
ATOM   2315 C C   . PHE B 1 108 ? 29.517  3.136   39.827 1.000 30.484  0 108 PHE B C   1 ? 
ATOM   2316 O O   . PHE B 1 108 ? 30.526  2.488   39.611 1.000 35.496  0 108 PHE B O   1 ? 
ATOM   2317 C CB  . PHE B 1 108 ? 28.834  3.341   42.275 1.000 34.231  0 108 PHE B CB  1 ? 
ATOM   2318 C CG  . PHE B 1 108 ? 29.174  3.967   43.598 1.000 35.036  0 108 PHE B CG  1 ? 
ATOM   2319 C CD1 . PHE B 1 108 ? 30.489  4.242   43.919 1.000 41.799  0 108 PHE B CD1 1 ? 
ATOM   2320 C CD2 . PHE B 1 108 ? 28.198  4.234   44.538 1.000 37.895  0 108 PHE B CD2 1 ? 
ATOM   2321 C CE1 . PHE B 1 108 ? 30.824  4.816   45.131 1.000 37.425  0 108 PHE B CE1 1 ? 
ATOM   2322 C CE2 . PHE B 1 108 ? 28.533  4.812   45.751 1.000 38.192  0 108 PHE B CE2 1 ? 
ATOM   2323 C CZ  . PHE B 1 108 ? 29.840  5.094   46.047 1.000 35.881  0 108 PHE B CZ  1 ? 
ATOM   2324 N N   . LEU B 1 109 ? 28.480  3.142   38.984 1.000 29.480  0 109 LEU B N   1 ? 
ATOM   2325 C CA  . LEU B 1 109 ? 28.489  2.304   37.786 1.000 32.144  0 109 LEU B CA  1 ? 
ATOM   2326 C C   . LEU B 1 109 ? 29.656  2.673   36.869 1.000 33.429  0 109 LEU B C   1 ? 
ATOM   2327 O O   . LEU B 1 109 ? 30.369  1.812   36.364 1.000 29.840  0 109 LEU B O   1 ? 
ATOM   2328 C CB  . LEU B 1 109 ? 27.163  2.439   37.026 1.000 30.470  0 109 LEU B CB  1 ? 
ATOM   2329 C CG  . LEU B 1 109 ? 26.889  1.360   35.971 1.000 30.994  0 109 LEU B CG  1 ? 
ATOM   2330 C CD1 . LEU B 1 109 ? 27.219  -0.036  36.481 1.000 30.627  0 109 LEU B CD1 1 ? 
ATOM   2331 C CD2 . LEU B 1 109 ? 25.435  1.359   35.519 1.000 30.758  0 109 LEU B CD2 1 ? 
ATOM   2332 N N   . VAL B 1 110 ? 29.832  3.980   36.674 1.000 35.810  0 110 VAL B N   1 ? 
ATOM   2333 C CA  . VAL B 1 110 ? 30.786  4.528   35.731 1.000 35.914  0 110 VAL B CA  1 ? 
ATOM   2334 C C   . VAL B 1 110 ? 32.190  4.255   36.244 1.000 37.830  0 110 VAL B C   1 ? 
ATOM   2335 O O   . VAL B 1 110 ? 33.092  4.123   35.441 1.000 44.319  0 110 VAL B O   1 ? 
ATOM   2336 C CB  . VAL B 1 110 ? 30.548  6.044   35.545 1.000 36.344  0 110 VAL B CB  1 ? 
ATOM   2337 C CG1 . VAL B 1 110 ? 31.754  6.771   34.989 1.000 36.137  0 110 VAL B CG1 1 ? 
ATOM   2338 C CG2 . VAL B 1 110 ? 29.325  6.329   34.693 1.000 34.104  0 110 VAL B CG2 1 ? 
ATOM   2339 N N   . GLU B 1 111 ? 32.371  4.241   37.573 1.000 45.138  0 111 GLU B N   1 ? 
ATOM   2340 C CA  . GLU B 1 111 ? 33.647  3.907   38.193 1.000 46.156  0 111 GLU B CA  1 ? 
ATOM   2341 C C   . GLU B 1 111 ? 33.950  2.424   37.960 1.000 40.485  0 111 GLU B C   1 ? 
ATOM   2342 O O   . GLU B 1 111 ? 35.056  2.051   37.581 1.000 38.071  0 111 GLU B O   1 ? 
ATOM   2343 C CB  . GLU B 1 111 ? 33.627  4.199   39.699 1.000 54.202  0 111 GLU B CB  1 ? 
ATOM   2344 C CG  . GLU B 1 111 ? 33.717  5.670   40.103 1.000 58.271  0 111 GLU B CG  1 ? 
ATOM   2345 C CD  . GLU B 1 111 ? 33.712  5.953   41.611 1.000 57.648  0 111 GLU B CD  1 ? 
ATOM   2346 O OE1 . GLU B 1 111 ? 33.780  4.977   42.435 1.000 50.768  0 111 GLU B OE1 1 ? 
ATOM   2347 O OE2 . GLU B 1 111 ? 33.629  7.158   41.979 1.000 46.195  0 111 GLU B OE2 1 ? 
ATOM   2348 N N   . LEU B 1 112 ? 32.949  1.571   38.185 1.000 38.714  0 112 LEU B N   1 ? 
ATOM   2349 C CA  . LEU B 1 112 ? 33.106  0.148   37.953 1.000 39.075  0 112 LEU B CA  1 ? 
ATOM   2350 C C   . LEU B 1 112 ? 33.462  -0.103  36.498 1.000 36.797  0 112 LEU B C   1 ? 
ATOM   2351 O O   . LEU B 1 112 ? 34.257  -0.985  36.224 1.000 37.545  0 112 LEU B O   1 ? 
ATOM   2352 C CB  . LEU B 1 112 ? 31.814  -0.592  38.322 1.000 38.581  0 112 LEU B CB  1 ? 
ATOM   2353 C CG  . LEU B 1 112 ? 31.650  -0.951  39.803 1.000 36.789  0 112 LEU B CG  1 ? 
ATOM   2354 C CD1 . LEU B 1 112 ? 32.718  -0.308  40.672 1.000 39.128  0 112 LEU B CD1 1 ? 
ATOM   2355 C CD2 . LEU B 1 112 ? 30.268  -0.614  40.341 1.000 33.523  0 112 LEU B CD2 1 ? 
ATOM   2356 N N   . GLU B 1 113 ? 32.888  0.708   35.604 1.000 35.435  0 113 GLU B N   1 ? 
ATOM   2357 C CA  . GLU B 1 113 ? 32.900  0.456   34.172 1.000 38.623  0 113 GLU B CA  1 ? 
ATOM   2358 C C   . GLU B 1 113 ? 34.201  0.934   33.537 1.000 34.911  0 113 GLU B C   1 ? 
ATOM   2359 O O   . GLU B 1 113 ? 34.341  0.917   32.317 1.000 38.248  0 113 GLU B O   1 ? 
ATOM   2360 C CB  . GLU B 1 113 ? 31.699  1.128   33.498 1.000 41.970  0 113 GLU B CB  1 ? 
ATOM   2361 C CG  . GLU B 1 113 ? 30.410  0.318   33.572 1.000 45.245  0 113 GLU B CG  1 ? 
ATOM   2362 C CD  . GLU B 1 113 ? 29.145  1.100   33.246 1.000 48.111  0 113 GLU B CD  1 ? 
ATOM   2363 O OE1 . GLU B 1 113 ? 29.253  2.351   33.130 1.000 47.273  0 113 GLU B OE1 1 ? 
ATOM   2364 O OE2 . GLU B 1 113 ? 28.047  0.469   33.127 1.000 50.265  0 113 GLU B OE2 1 ? 
ATOM   2365 N N   . LYS B 1 114 ? 35.154  1.372   34.354 1.000 38.348  0 114 LYS B N   1 ? 
ATOM   2366 C CA  . LYS B 1 114 ? 36.512  1.587   33.874 1.000 41.925  0 114 LYS B CA  1 ? 
ATOM   2367 C C   . LYS B 1 114 ? 37.205  0.242   33.684 1.000 41.130  0 114 LYS B C   1 ? 
ATOM   2368 O O   . LYS B 1 114 ? 38.034  0.091   32.778 1.000 47.508  0 114 LYS B O   1 ? 
ATOM   2369 C CB  . LYS B 1 114 ? 37.302  2.455   34.847 1.000 39.348  0 114 LYS B CB  1 ? 
ATOM   2370 C CG  . LYS B 1 114 ? 36.718  3.842   35.053 1.000 44.976  0 114 LYS B CG  1 ? 
ATOM   2371 C CD  . LYS B 1 114 ? 36.592  4.692   33.801 1.000 42.258  0 114 LYS B CD  1 ? 
ATOM   2372 C CE  . LYS B 1 114 ? 35.950  6.023   34.130 1.000 47.540  0 114 LYS B CE  1 ? 
ATOM   2373 N NZ  . LYS B 1 114 ? 36.320  7.103   33.185 1.000 56.095  0 114 LYS B NZ  1 ? 
ATOM   2374 N N   . SER B 1 115 ? 36.846  -0.724  34.541 1.000 37.245  0 115 SER B N   1 ? 
ATOM   2375 C CA  . SER B 1 115 ? 37.399  -2.062  34.450 1.000 36.524  0 115 SER B CA  1 ? 
ATOM   2376 C C   . SER B 1 115 ? 36.869  -2.760  33.205 1.000 36.512  0 115 SER B C   1 ? 
ATOM   2377 O O   . SER B 1 115 ? 35.656  -2.919  33.056 1.000 39.855  0 115 SER B O   1 ? 
ATOM   2378 C CB  . SER B 1 115 ? 37.094  -2.853  35.670 1.000 35.080  0 115 SER B CB  1 ? 
ATOM   2379 O OG  . SER B 1 115 ? 37.276  -4.235  35.410 1.000 36.553  0 115 SER B OG  1 ? 
ATOM   2380 N N   . SER B 1 116 ? 37.799  -3.139  32.329 1.000 38.226  0 116 SER B N   1 ? 
ATOM   2381 C CA  . SER B 1 116 ? 37.502  -3.956  31.161 1.000 45.863  0 116 SER B CA  1 ? 
ATOM   2382 C C   . SER B 1 116 ? 36.919  -5.309  31.587 1.000 47.211  0 116 SER B C   1 ? 
ATOM   2383 O O   . SER B 1 116 ? 35.940  -5.778  31.010 1.000 54.390  0 116 SER B O   1 ? 
ATOM   2384 C CB  . SER B 1 116 ? 38.742  -4.118  30.293 1.000 42.080  0 116 SER B CB  1 ? 
ATOM   2385 N N   . LYS B 1 117 ? 37.504  -5.917  32.628 1.000 43.777  0 117 LYS B N   1 ? 
ATOM   2386 C CA  . LYS B 1 117 ? 37.043  -7.194  33.148 1.000 40.945  0 117 LYS B CA  1 ? 
ATOM   2387 C C   . LYS B 1 117 ? 35.593  -7.070  33.616 1.000 39.903  0 117 LYS B C   1 ? 
ATOM   2388 O O   . LYS B 1 117 ? 34.775  -7.949  33.371 1.000 45.169  0 117 LYS B O   1 ? 
ATOM   2389 C CB  . LYS B 1 117 ? 37.986  -7.633  34.268 1.000 45.691  0 117 LYS B CB  1 ? 
ATOM   2390 C CG  . LYS B 1 117 ? 37.563  -8.879  35.022 1.000 52.924  0 117 LYS B CG  1 ? 
ATOM   2391 C CD  . LYS B 1 117 ? 38.634  -9.410  35.958 1.000 56.215  0 117 LYS B CD  1 ? 
ATOM   2392 C CE  . LYS B 1 117 ? 38.356  -10.841 36.378 1.000 61.613  0 117 LYS B CE  1 ? 
ATOM   2393 N NZ  . LYS B 1 117 ? 39.590  -11.561 36.785 1.000 63.588  0 117 LYS B NZ  1 ? 
ATOM   2394 N N   . PHE B 1 118 ? 35.271  -5.955  34.277 1.000 38.832  0 118 PHE B N   1 ? 
ATOM   2395 C CA  . PHE B 1 118 ? 33.936  -5.740  34.796 1.000 37.481  0 118 PHE B CA  1 ? 
ATOM   2396 C C   . PHE B 1 118 ? 32.934  -5.697  33.657 1.000 39.123  0 118 PHE B C   1 ? 
ATOM   2397 O O   . PHE B 1 118 ? 31.918  -6.383  33.702 1.000 36.954  0 118 PHE B O   1 ? 
ATOM   2398 C CB  . PHE B 1 118 ? 33.842  -4.400  35.508 1.000 38.588  0 118 PHE B CB  1 ? 
ATOM   2399 C CG  . PHE B 1 118 ? 32.439  -4.074  35.931 1.000 37.567  0 118 PHE B CG  1 ? 
ATOM   2400 C CD1 . PHE B 1 118 ? 31.871  -4.714  37.013 1.000 38.571  0 118 PHE B CD1 1 ? 
ATOM   2401 C CD2 . PHE B 1 118 ? 31.683  -3.153  35.236 1.000 37.450  0 118 PHE B CD2 1 ? 
ATOM   2402 C CE1 . PHE B 1 118 ? 30.582  -4.416  37.407 1.000 37.663  0 118 PHE B CE1 1 ? 
ATOM   2403 C CE2 . PHE B 1 118 ? 30.394  -2.853  35.636 1.000 36.963  0 118 PHE B CE2 1 ? 
ATOM   2404 C CZ  . PHE B 1 118 ? 29.845  -3.499  36.710 1.000 36.399  0 118 PHE B CZ  1 ? 
ATOM   2405 N N   . ASN B 1 119 ? 33.262  -4.901  32.630 1.000 38.646  0 119 ASN B N   1 ? 
ATOM   2406 C CA  . ASN B 1 119 ? 32.423  -4.796  31.447 1.000 40.623  0 119 ASN B CA  1 ? 
ATOM   2407 C C   . ASN B 1 119 ? 32.136  -6.166  30.829 1.000 43.543  0 119 ASN B C   1 ? 
ATOM   2408 O O   . ASN B 1 119 ? 31.012  -6.422  30.396 1.000 49.156  0 119 ASN B O   1 ? 
ATOM   2409 C CB  . ASN B 1 119 ? 33.010  -3.825  30.427 1.000 39.858  0 119 ASN B CB  1 ? 
ATOM   2410 C CG  . ASN B 1 119 ? 32.749  -2.390  30.805 1.000 38.157  0 119 ASN B CG  1 ? 
ATOM   2411 O OD1 . ASN B 1 119 ? 31.612  -2.030  31.090 1.000 51.004  0 119 ASN B OD1 1 ? 
ATOM   2412 N ND2 . ASN B 1 119 ? 33.782  -1.569  30.833 1.000 36.751  0 119 ASN B ND2 1 ? 
ATOM   2413 N N   . ASP B 1 120 ? 33.127  -7.060  30.811 1.000 46.416  0 120 ASP B N   1 ? 
ATOM   2414 C CA  . ASP B 1 120 ? 32.937  -8.369  30.203 1.000 49.847  0 120 ASP B CA  1 ? 
ATOM   2415 C C   . ASP B 1 120 ? 31.956  -9.206  31.020 1.000 42.736  0 120 ASP B C   1 ? 
ATOM   2416 O O   . ASP B 1 120 ? 31.216  -10.018 30.481 1.000 40.373  0 120 ASP B O   1 ? 
ATOM   2417 C CB  . ASP B 1 120 ? 34.266  -9.107  30.071 1.000 57.430  0 120 ASP B CB  1 ? 
ATOM   2418 C CG  . ASP B 1 120 ? 35.271  -8.372  29.197 1.000 66.473  0 120 ASP B CG  1 ? 
ATOM   2419 O OD1 . ASP B 1 120 ? 34.872  -7.922  28.087 1.000 62.477  0 120 ASP B OD1 1 ? 
ATOM   2420 O OD2 . ASP B 1 120 ? 36.447  -8.261  29.627 1.000 81.107  0 120 ASP B OD2 1 ? 
ATOM   2421 N N   . ILE B 1 121 ? 32.001  -9.038  32.337 1.000 41.402  0 121 ILE B N   1 ? 
ATOM   2422 C CA  . ILE B 1 121 ? 31.158  -9.812  33.230 1.000 39.259  0 121 ILE B CA  1 ? 
ATOM   2423 C C   . ILE B 1 121 ? 29.721  -9.387  32.952 1.000 38.353  0 121 ILE B C   1 ? 
ATOM   2424 O O   . ILE B 1 121 ? 28.847  -10.227 32.765 1.000 38.805  0 121 ILE B O   1 ? 
ATOM   2425 C CB  . ILE B 1 121 ? 31.607  -9.581  34.694 1.000 36.568  0 121 ILE B CB  1 ? 
ATOM   2426 C CG1 . ILE B 1 121 ? 33.013  -10.121 34.928 1.000 36.463  0 121 ILE B CG1 1 ? 
ATOM   2427 C CG2 . ILE B 1 121 ? 30.642  -10.181 35.697 1.000 36.662  0 121 ILE B CG2 1 ? 
ATOM   2428 C CD1 . ILE B 1 121 ? 33.518  -9.902  36.331 1.000 42.394  0 121 ILE B CD1 1 ? 
ATOM   2429 N N   . LEU B 1 122 ? 29.526  -8.065  32.863 1.000 38.163  0 122 LEU B N   1 ? 
ATOM   2430 C CA  . LEU B 1 122 ? 28.232  -7.462  32.627 1.000 40.204  0 122 LEU B CA  1 ? 
ATOM   2431 C C   . LEU B 1 122 ? 27.679  -7.941  31.281 1.000 41.578  0 122 LEU B C   1 ? 
ATOM   2432 O O   . LEU B 1 122 ? 26.516  -8.340  31.191 1.000 41.474  0 122 LEU B O   1 ? 
ATOM   2433 C CB  . LEU B 1 122 ? 28.403  -5.933  32.710 1.000 44.379  0 122 LEU B CB  1 ? 
ATOM   2434 C CG  . LEU B 1 122 ? 27.294  -5.148  33.437 1.000 47.655  0 122 LEU B CG  1 ? 
ATOM   2435 C CD1 . LEU B 1 122 ? 27.103  -5.631  34.869 1.000 52.442  0 122 LEU B CD1 1 ? 
ATOM   2436 C CD2 . LEU B 1 122 ? 27.579  -3.652  33.441 1.000 44.440  0 122 LEU B CD2 1 ? 
ATOM   2437 N N   . ASP B 1 123 ? 28.516  -7.913  30.236 1.000 44.637  0 123 ASP B N   1 ? 
ATOM   2438 C CA  . ASP B 1 123 ? 28.130  -8.390  28.914 1.000 42.048  0 123 ASP B CA  1 ? 
ATOM   2439 C C   . ASP B 1 123 ? 27.802  -9.882  28.997 1.000 38.974  0 123 ASP B C   1 ? 
ATOM   2440 O O   . ASP B 1 123 ? 26.817  -10.359 28.441 1.000 33.411  0 123 ASP B O   1 ? 
ATOM   2441 C CB  . ASP B 1 123 ? 29.220  -8.067  27.884 1.000 44.174  0 123 ASP B CB  1 ? 
ATOM   2442 N N   . LEU B 1 124 ? 28.575  -10.617 29.787 1.000 42.195  0 124 LEU B N   1 ? 
ATOM   2443 C CA  . LEU B 1 124 ? 28.280  -12.023 29.990 1.000 48.241  0 124 LEU B CA  1 ? 
ATOM   2444 C C   . LEU B 1 124 ? 26.917  -12.223 30.659 1.000 41.542  0 124 LEU B C   1 ? 
ATOM   2445 O O   . LEU B 1 124 ? 26.124  -13.020 30.179 1.000 40.663  0 124 LEU B O   1 ? 
ATOM   2446 C CB  . LEU B 1 124 ? 29.419  -12.665 30.781 1.000 56.824  0 124 LEU B CB  1 ? 
ATOM   2447 C CG  . LEU B 1 124 ? 29.727  -14.100 30.374 1.000 70.489  0 124 LEU B CG  1 ? 
ATOM   2448 C CD1 . LEU B 1 124 ? 30.275  -14.149 28.950 1.000 66.046  0 124 LEU B CD1 1 ? 
ATOM   2449 C CD2 . LEU B 1 124 ? 30.692  -14.732 31.366 1.000 79.983  0 124 LEU B CD2 1 ? 
ATOM   2450 N N   . LEU B 1 125 ? 26.633  -11.502 31.750 1.000 39.938  0 125 LEU B N   1 ? 
ATOM   2451 C CA  . LEU B 1 125 ? 25.366  -11.649 32.467 1.000 40.141  0 125 LEU B CA  1 ? 
ATOM   2452 C C   . LEU B 1 125 ? 24.162  -11.316 31.579 1.000 41.617  0 125 LEU B C   1 ? 
ATOM   2453 O O   . LEU B 1 125 ? 23.105  -11.951 31.667 1.000 32.846  0 125 LEU B O   1 ? 
ATOM   2454 C CB  . LEU B 1 125 ? 25.391  -10.738 33.702 1.000 38.769  0 125 LEU B CB  1 ? 
ATOM   2455 C CG  . LEU B 1 125 ? 26.187  -11.290 34.893 1.000 38.262  0 125 LEU B CG  1 ? 
ATOM   2456 C CD1 . LEU B 1 125 ? 26.189  -10.325 36.071 1.000 37.001  0 125 LEU B CD1 1 ? 
ATOM   2457 C CD2 . LEU B 1 125 ? 25.627  -12.621 35.352 1.000 34.596  0 125 LEU B CD2 1 ? 
ATOM   2458 N N   . ARG B 1 126 ? 24.341  -10.299 30.724 1.000 43.605  0 126 ARG B N   1 ? 
ATOM   2459 C CA  . ARG B 1 126 ? 23.328  -9.882  29.774 1.000 42.632  0 126 ARG B CA  1 ? 
ATOM   2460 C C   . ARG B 1 126 ? 22.972  -11.014 28.811 1.000 46.082  0 126 ARG B C   1 ? 
ATOM   2461 O O   . ARG B 1 126 ? 21.802  -11.275 28.540 1.000 42.611  0 126 ARG B O   1 ? 
ATOM   2462 C CB  . ARG B 1 126 ? 23.851  -8.701  28.961 1.000 39.574  0 126 ARG B CB  1 ? 
ATOM   2463 C CG  . ARG B 1 126 ? 22.785  -8.107  28.052 1.000 41.356  0 126 ARG B CG  1 ? 
ATOM   2464 C CD  . ARG B 1 126 ? 23.245  -6.826  27.396 1.000 43.804  0 126 ARG B CD  1 ? 
ATOM   2465 N NE  . ARG B 1 126 ? 22.263  -6.403  26.417 1.000 48.814  0 126 ARG B NE  1 ? 
ATOM   2466 C CZ  . ARG B 1 126 ? 22.378  -5.325  25.658 1.000 52.549  0 126 ARG B CZ  1 ? 
ATOM   2467 N NH1 . ARG B 1 126 ? 23.468  -4.584  25.749 1.000 53.718  0 126 ARG B NH1 1 ? 
ATOM   2468 N NH2 . ARG B 1 126 ? 21.387  -4.977  24.851 1.000 47.804  0 126 ARG B NH2 1 ? 
ATOM   2469 N N   . SER B 1 127 ? 24.018  -11.659 28.279 1.000 55.782  0 127 SER B N   1 ? 
ATOM   2470 C CA  . SER B 1 127 ? 23.851  -12.726 27.310 1.000 51.086  0 127 SER B CA  1 ? 
ATOM   2471 C C   . SER B 1 127 ? 23.031  -13.857 27.927 1.000 46.194  0 127 SER B C   1 ? 
ATOM   2472 O O   . SER B 1 127 ? 22.505  -14.669 27.184 1.000 46.496  0 127 SER B O   1 ? 
ATOM   2473 C CB  . SER B 1 127 ? 25.180  -13.187 26.768 1.000 48.875  0 127 SER B CB  1 ? 
ATOM   2474 O OG  . SER B 1 127 ? 25.873  -13.965 27.720 1.000 57.105  0 127 SER B OG  1 ? 
ATOM   2475 N N   . HIS B 1 128 ? 22.849  -13.866 29.258 1.000 44.790  0 128 HIS B N   1 ? 
ATOM   2476 C CA  . HIS B 1 128 ? 22.043  -14.890 29.914 1.000 48.174  0 128 HIS B CA  1 ? 
ATOM   2477 C C   . HIS B 1 128 ? 20.643  -14.413 30.251 1.000 42.936  0 128 HIS B C   1 ? 
ATOM   2478 O O   . HIS B 1 128 ? 19.867  -15.181 30.793 1.000 41.838  0 128 HIS B O   1 ? 
ATOM   2479 C CB  . HIS B 1 128 ? 22.682  -15.378 31.219 1.000 51.492  0 128 HIS B CB  1 ? 
ATOM   2480 C CG  . HIS B 1 128 ? 23.968  -16.064 30.953 1.000 64.098  0 128 HIS B CG  1 ? 
ATOM   2481 N ND1 . HIS B 1 128 ? 25.039  -15.987 31.813 1.000 74.238  0 128 HIS B ND1 1 ? 
ATOM   2482 C CD2 . HIS B 1 128 ? 24.395  -16.750 29.873 1.000 73.297  0 128 HIS B CD2 1 ? 
ATOM   2483 C CE1 . HIS B 1 128 ? 26.057  -16.659 31.289 1.000 88.671  0 128 HIS B CE1 1 ? 
ATOM   2484 N NE2 . HIS B 1 128 ? 25.687  -17.119 30.105 1.000 87.258  0 128 HIS B NE2 1 ? 
ATOM   2485 N N   . LEU B 1 129 ? 20.352  -13.142 30.003 1.000 46.257  0 129 LEU B N   1 ? 
ATOM   2486 C CA  . LEU B 1 129 ? 19.006  -12.641 30.208 1.000 51.095  0 129 LEU B CA  1 ? 
ATOM   2487 C C   . LEU B 1 129 ? 18.020  -13.302 29.237 1.000 56.874  0 129 LEU B C   1 ? 
ATOM   2488 O O   . LEU B 1 129 ? 18.339  -13.519 28.068 1.000 58.992  0 129 LEU B O   1 ? 
ATOM   2489 C CB  . LEU B 1 129 ? 19.039  -11.126 30.025 1.000 50.275  0 129 LEU B CB  1 ? 
ATOM   2490 C CG  . LEU B 1 129 ? 19.001  -10.287 31.297 1.000 45.573  0 129 LEU B CG  1 ? 
ATOM   2491 C CD1 . LEU B 1 129 ? 19.838  -10.881 32.413 1.000 46.545  0 129 LEU B CD1 1 ? 
ATOM   2492 C CD2 . LEU B 1 129 ? 19.443  -8.879  30.947 1.000 44.552  0 129 LEU B CD2 1 ? 
ATOM   2493 N N   . PRO B 1 130 ? 16.777  -13.611 29.678 1.000 61.271  0 130 PRO B N   1 ? 
ATOM   2494 C CA  . PRO B 1 130 ? 15.767  -14.205 28.799 1.000 68.464  0 130 PRO B CA  1 ? 
ATOM   2495 C C   . PRO B 1 130 ? 15.205  -13.249 27.746 1.000 79.958  0 130 PRO B C   1 ? 
ATOM   2496 O O   . PRO B 1 130 ? 15.275  -12.031 27.901 1.000 85.925  0 130 PRO B O   1 ? 
ATOM   2497 C CB  . PRO B 1 130 ? 14.644  -14.598 29.773 1.000 65.557  0 130 PRO B CB  1 ? 
ATOM   2498 C CG  . PRO B 1 130 ? 14.780  -13.611 30.899 1.000 62.274  0 130 PRO B CG  1 ? 
ATOM   2499 C CD  . PRO B 1 130 ? 16.271  -13.404 31.046 1.000 63.397  0 130 PRO B CD  1 ? 
ATOM   2500 N N   . GLY B 1 131 ? 14.608  -13.820 26.693 1.000 80.002  0 131 GLY B N   1 ? 
ATOM   2501 C CA  . GLY B 1 131 ? 13.900  -13.036 25.693 1.000 77.984  0 131 GLY B CA  1 ? 
ATOM   2502 C C   . GLY B 1 131 ? 14.863  -12.420 24.685 1.000 81.662  0 131 GLY B C   1 ? 
ATOM   2503 O O   . GLY B 1 131 ? 16.065  -12.683 24.730 1.000 79.404  0 131 GLY B O   1 ? 
ATOM   2504 N N   . ASP B 1 132 ? 14.306  -11.627 23.763 1.000 82.728  0 132 ASP B N   1 ? 
ATOM   2505 C CA  . ASP B 1 132 ? 15.070  -10.959 22.722 1.000 83.512  0 132 ASP B CA  1 ? 
ATOM   2506 C C   . ASP B 1 132 ? 15.518  -9.600  23.253 1.000 84.348  0 132 ASP B C   1 ? 
ATOM   2507 O O   . ASP B 1 132 ? 16.616  -9.133  22.942 1.000 77.683  0 132 ASP B O   1 ? 
ATOM   2508 C CB  . ASP B 1 132 ? 14.249  -10.847 21.431 1.000 86.621  0 132 ASP B CB  1 ? 
ATOM   2509 N N   . ASN B 1 133 ? 14.645  -8.985  24.065 1.000 89.067  0 133 ASN B N   1 ? 
ATOM   2510 C CA  . ASN B 1 133 ? 14.966  -7.796  24.846 1.000 91.932  0 133 ASN B CA  1 ? 
ATOM   2511 C C   . ASN B 1 133 ? 15.863  -8.180  26.028 1.000 89.002  0 133 ASN B C   1 ? 
ATOM   2512 O O   . ASN B 1 133 ? 15.398  -8.373  27.159 1.000 84.934  0 133 ASN B O   1 ? 
ATOM   2513 C CB  . ASN B 1 133 ? 13.699  -7.075  25.326 1.000 85.317  0 133 ASN B CB  1 ? 
ATOM   2514 N N   . GLN B 1 134 ? 17.152  -8.364  25.722 1.000 75.878  0 134 GLN B N   1 ? 
ATOM   2515 C CA  . GLN B 1 134 ? 18.183  -8.424  26.744 1.000 67.043  0 134 GLN B CA  1 ? 
ATOM   2516 C C   . GLN B 1 134 ? 18.812  -7.042  26.887 1.000 55.722  0 134 GLN B C   1 ? 
ATOM   2517 O O   . GLN B 1 134 ? 19.767  -6.722  26.181 1.000 41.999  0 134 GLN B O   1 ? 
ATOM   2518 C CB  . GLN B 1 134 ? 19.275  -9.422  26.351 1.000 68.126  0 134 GLN B CB  1 ? 
ATOM   2519 C CG  . GLN B 1 134 ? 18.749  -10.807 26.032 1.000 67.493  0 134 GLN B CG  1 ? 
ATOM   2520 C CD  . GLN B 1 134 ? 19.890  -11.672 25.567 1.000 65.960  0 134 GLN B CD  1 ? 
ATOM   2521 O OE1 . GLN B 1 134 ? 20.599  -11.317 24.626 1.000 60.542  0 134 GLN B OE1 1 ? 
ATOM   2522 N NE2 . GLN B 1 134 ? 20.112  -12.774 26.270 1.000 64.228  0 134 GLN B NE2 1 ? 
ATOM   2523 N N   . LEU B 1 135 ? 18.298  -6.219  27.809 1.000 52.083  0 135 LEU B N   1 ? 
ATOM   2524 C CA  . LEU B 1 135 ? 18.801  -4.859  27.933 1.000 50.526  0 135 LEU B CA  1 ? 
ATOM   2525 C C   . LEU B 1 135 ? 20.056  -4.810  28.805 1.000 41.934  0 135 LEU B C   1 ? 
ATOM   2526 O O   . LEU B 1 135 ? 20.308  -5.692  29.622 1.000 37.383  0 135 LEU B O   1 ? 
ATOM   2527 C CB  . LEU B 1 135 ? 17.692  -3.955  28.472 1.000 49.064  0 135 LEU B CB  1 ? 
ATOM   2528 C CG  . LEU B 1 135 ? 16.482  -3.815  27.545 1.000 54.449  0 135 LEU B CG  1 ? 
ATOM   2529 C CD1 . LEU B 1 135 ? 15.311  -3.128  28.243 1.000 54.965  0 135 LEU B CD1 1 ? 
ATOM   2530 C CD2 . LEU B 1 135 ? 16.849  -3.055  26.277 1.000 55.130  0 135 LEU B CD2 1 ? 
ATOM   2531 N N   . ASP B 1 136 ? 20.848  -3.757  28.594 1.000 37.604  0 136 ASP B N   1 ? 
ATOM   2532 C CA  . ASP B 1 136 ? 21.956  -3.437  29.470 1.000 42.615  0 136 ASP B CA  1 ? 
ATOM   2533 C C   . ASP B 1 136 ? 21.411  -2.942  30.814 1.000 44.351  0 136 ASP B C   1 ? 
ATOM   2534 O O   . ASP B 1 136 ? 20.209  -2.725  30.992 1.000 38.410  0 136 ASP B O   1 ? 
ATOM   2535 C CB  . ASP B 1 136 ? 22.870  -2.399  28.819 1.000 46.621  0 136 ASP B CB  1 ? 
ATOM   2536 C CG  . ASP B 1 136 ? 22.191  -1.066  28.554 1.000 50.587  0 136 ASP B CG  1 ? 
ATOM   2537 O OD1 . ASP B 1 136 ? 21.075  -1.070  27.962 1.000 53.875  0 136 ASP B OD1 1 ? 
ATOM   2538 O OD2 . ASP B 1 136 ? 22.755  -0.044  28.992 1.000 52.426  0 136 ASP B OD2 1 ? 
ATOM   2539 N N   . LEU B 1 137 ? 22.330  -2.763  31.764 1.000 39.546  0 137 LEU B N   1 ? 
ATOM   2540 C CA  . LEU B 1 137 ? 21.988  -2.413  33.127 1.000 38.745  0 137 LEU B CA  1 ? 
ATOM   2541 C C   . LEU B 1 137 ? 21.295  -1.050  33.160 1.000 39.574  0 137 LEU B C   1 ? 
ATOM   2542 O O   . LEU B 1 137 ? 20.175  -0.953  33.643 1.000 40.006  0 137 LEU B O   1 ? 
ATOM   2543 C CB  . LEU B 1 137 ? 23.297  -2.440  33.925 1.000 38.428  0 137 LEU B CB  1 ? 
ATOM   2544 C CG  . LEU B 1 137 ? 23.182  -2.447  35.439 1.000 36.079  0 137 LEU B CG  1 ? 
ATOM   2545 C CD1 . LEU B 1 137 ? 21.996  -3.305  35.900 1.000 34.783  0 137 LEU B CD1 1 ? 
ATOM   2546 C CD2 . LEU B 1 137 ? 24.482  -2.941  36.041 1.000 36.058  0 137 LEU B CD2 1 ? 
ATOM   2547 N N   . ARG B 1 138 ? 21.926  -0.004  32.606 1.000 40.894  0 138 ARG B N   1 ? 
ATOM   2548 C CA  . ARG B 1 138 ? 21.377  1.347   32.658 1.000 42.285  0 138 ARG B CA  1 ? 
ATOM   2549 C C   . ARG B 1 138 ? 19.918  1.341   32.228 1.000 40.854  0 138 ARG B C   1 ? 
ATOM   2550 O O   . ARG B 1 138 ? 19.058  2.047   32.749 1.000 33.741  0 138 ARG B O   1 ? 
ATOM   2551 C CB  . ARG B 1 138 ? 22.091  2.265   31.667 1.000 42.201  0 138 ARG B CB  1 ? 
ATOM   2552 C CG  . ARG B 1 138 ? 23.478  2.679   32.113 1.000 44.935  0 138 ARG B CG  1 ? 
ATOM   2553 C CD  . ARG B 1 138 ? 24.398  2.814   30.926 1.000 45.069  0 138 ARG B CD  1 ? 
ATOM   2554 N NE  . ARG B 1 138 ? 25.760  2.918   31.399 1.000 41.913  0 138 ARG B NE  1 ? 
ATOM   2555 C CZ  . ARG B 1 138 ? 26.301  4.012   31.913 1.000 47.379  0 138 ARG B CZ  1 ? 
ATOM   2556 N NH1 . ARG B 1 138 ? 25.625  5.147   31.968 1.000 54.169  0 138 ARG B NH1 1 ? 
ATOM   2557 N NH2 . ARG B 1 138 ? 27.543  3.980   32.360 1.000 47.297  0 138 ARG B NH2 1 ? 
ATOM   2558 N N   . SER B 1 139 ? 19.673  0.528   31.210 1.000 38.017  0 139 SER B N   1 ? 
ATOM   2559 C CA  . SER B 1 139 ? 18.363  0.450   30.606 1.000 36.930  0 139 SER B CA  1 ? 
ATOM   2560 C C   . SER B 1 139 ? 17.342  -0.160  31.581 1.000 33.707  0 139 SER B C   1 ? 
ATOM   2561 O O   . SER B 1 139 ? 16.142  0.077   31.441 1.000 35.306  0 139 SER B O   1 ? 
ATOM   2562 C CB  . SER B 1 139 ? 18.498  -0.268  29.281 1.000 35.635  0 139 SER B CB  1 ? 
ATOM   2563 O OG  . SER B 1 139 ? 17.280  -0.854  28.900 1.000 42.030  0 139 SER B OG  1 ? 
ATOM   2564 N N   . TYR B 1 140 ? 17.804  -0.888  32.608 1.000 31.423  0 140 TYR B N   1 ? 
ATOM   2565 C CA  . TYR B 1 140 ? 16.928  -1.338  33.681 1.000 34.222  0 140 TYR B CA  1 ? 
ATOM   2566 C C   . TYR B 1 140 ? 16.857  -0.296  34.808 1.000 32.022  0 140 TYR B C   1 ? 
ATOM   2567 O O   . TYR B 1 140 ? 15.785  -0.013  35.321 1.000 30.797  0 140 TYR B O   1 ? 
ATOM   2568 C CB  . TYR B 1 140 ? 17.355  -2.724  34.192 1.000 36.609  0 140 TYR B CB  1 ? 
ATOM   2569 C CG  . TYR B 1 140 ? 17.074  -3.839  33.221 1.000 32.218  0 140 TYR B CG  1 ? 
ATOM   2570 C CD1 . TYR B 1 140 ? 15.778  -4.155  32.887 1.000 35.659  0 140 TYR B CD1 1 ? 
ATOM   2571 C CD2 . TYR B 1 140 ? 18.086  -4.558  32.608 1.000 33.760  0 140 TYR B CD2 1 ? 
ATOM   2572 C CE1 . TYR B 1 140 ? 15.480  -5.151  31.973 1.000 34.799  0 140 TYR B CE1 1 ? 
ATOM   2573 C CE2 . TYR B 1 140 ? 17.810  -5.561  31.692 1.000 34.562  0 140 TYR B CE2 1 ? 
ATOM   2574 C CZ  . TYR B 1 140 ? 16.496  -5.838  31.355 1.000 34.729  0 140 TYR B CZ  1 ? 
ATOM   2575 O OH  . TYR B 1 140 ? 16.120  -6.795  30.459 1.000 39.617  0 140 TYR B OH  1 ? 
ATOM   2576 N N   . LEU B 1 141 ? 17.996  0.247   35.228 1.000 32.679  0 141 LEU B N   1 ? 
ATOM   2577 C CA  . LEU B 1 141 ? 18.032  1.141   36.380 1.000 35.732  0 141 LEU B CA  1 ? 
ATOM   2578 C C   . LEU B 1 141 ? 17.223  2.414   36.124 1.000 32.567  0 141 LEU B C   1 ? 
ATOM   2579 O O   . LEU B 1 141 ? 16.816  3.066   37.071 1.000 37.444  0 141 LEU B O   1 ? 
ATOM   2580 C CB  . LEU B 1 141 ? 19.478  1.531   36.716 1.000 37.512  0 141 LEU B CB  1 ? 
ATOM   2581 C CG  . LEU B 1 141 ? 20.306  0.578   37.584 1.000 40.612  0 141 LEU B CG  1 ? 
ATOM   2582 C CD1 . LEU B 1 141 ? 19.452  -0.424  38.350 1.000 38.812  0 141 LEU B CD1 1 ? 
ATOM   2583 C CD2 . LEU B 1 141 ? 21.357  -0.135  36.757 1.000 41.242  0 141 LEU B CD2 1 ? 
ATOM   2584 N N   . ILE B 1 142 ? 16.992  2.753   34.860 1.000 27.574  0 142 ILE B N   1 ? 
ATOM   2585 C CA  . ILE B 1 142 ? 16.345  3.991   34.481 1.000 26.163  0 142 ILE B CA  1 ? 
ATOM   2586 C C   . ILE B 1 142 ? 14.835  3.820   34.511 1.000 24.919  0 142 ILE B C   1 ? 
ATOM   2587 O O   . ILE B 1 142 ? 14.122  4.804   34.609 1.000 23.369  0 142 ILE B O   1 ? 
ATOM   2588 C CB  . ILE B 1 142 ? 16.855  4.430   33.095 1.000 28.328  0 142 ILE B CB  1 ? 
ATOM   2589 C CG1 . ILE B 1 142 ? 16.561  5.893   32.776 1.000 27.623  0 142 ILE B CG1 1 ? 
ATOM   2590 C CG2 . ILE B 1 142 ? 16.324  3.511   32.006 1.000 31.470  0 142 ILE B CG2 1 ? 
ATOM   2591 C CD1 . ILE B 1 142 ? 17.092  6.852   33.791 1.000 30.517  0 142 ILE B CD1 1 ? 
ATOM   2592 N N   . MET B 1 143 ? 14.357  2.572   34.499 1.000 27.071  0 143 MET B N   1 ? 
ATOM   2593 C CA  . MET B 1 143 ? 12.951  2.299   34.268 1.000 31.269  0 143 MET B CA  1 ? 
ATOM   2594 C C   . MET B 1 143 ? 12.066  2.881   35.358 1.000 32.861  0 143 MET B C   1 ? 
ATOM   2595 O O   . MET B 1 143 ? 10.971  3.362   35.077 1.000 37.781  0 143 MET B O   1 ? 
ATOM   2596 C CB  . MET B 1 143 ? 12.674  0.805   34.161 1.000 34.552  0 143 MET B CB  1 ? 
ATOM   2597 C CG  . MET B 1 143 ? 12.837  0.298   32.772 1.000 38.164  0 143 MET B CG  1 ? 
ATOM   2598 S SD  . MET B 1 143 ? 12.594  -1.466  32.732 1.000 44.566  0 143 MET B SD  1 ? 
ATOM   2599 C CE  . MET B 1 143 ? 10.910  -1.518  32.103 1.000 56.654  0 143 MET B CE  1 ? 
ATOM   2600 N N   . PRO B 1 144 ? 12.442  2.796   36.643 1.000 33.884  0 144 PRO B N   1 ? 
ATOM   2601 C CA  . PRO B 1 144 ? 11.643  3.448   37.679 1.000 36.160  0 144 PRO B CA  1 ? 
ATOM   2602 C C   . PRO B 1 144 ? 11.590  4.942   37.431 1.000 34.978  0 144 PRO B C   1 ? 
ATOM   2603 O O   . PRO B 1 144 ? 10.568  5.570   37.663 1.000 40.024  0 144 PRO B O   1 ? 
ATOM   2604 C CB  . PRO B 1 144 ? 12.361  3.066   38.974 1.000 34.932  0 144 PRO B CB  1 ? 
ATOM   2605 C CG  . PRO B 1 144 ? 13.047  1.785   38.590 1.000 34.860  0 144 PRO B CG  1 ? 
ATOM   2606 C CD  . PRO B 1 144 ? 13.568  2.039   37.189 1.000 31.987  0 144 PRO B CD  1 ? 
ATOM   2607 N N   . VAL B 1 145 ? 12.679  5.489   36.904 1.000 36.567  0 145 VAL B N   1 ? 
ATOM   2608 C CA  . VAL B 1 145 ? 12.742  6.920   36.687 1.000 43.298  0 145 VAL B CA  1 ? 
ATOM   2609 C C   . VAL B 1 145 ? 11.758  7.272   35.577 1.000 44.787  0 145 VAL B C   1 ? 
ATOM   2610 O O   . VAL B 1 145 ? 11.193  8.379   35.591 1.000 49.250  0 145 VAL B O   1 ? 
ATOM   2611 C CB  . VAL B 1 145 ? 14.156  7.421   36.334 1.000 42.800  0 145 VAL B CB  1 ? 
ATOM   2612 C CG1 . VAL B 1 145 ? 14.228  8.943   36.446 1.000 40.685  0 145 VAL B CG1 1 ? 
ATOM   2613 C CG2 . VAL B 1 145 ? 15.236  6.748   37.171 1.000 38.728  0 145 VAL B CG2 1 ? 
ATOM   2614 N N   . GLN B 1 146 ? 11.597  6.342   34.620 1.000 36.908  0 146 GLN B N   1 ? 
ATOM   2615 C CA  . GLN B 1 146 ? 10.742  6.593   33.471 1.000 40.753  0 146 GLN B CA  1 ? 
ATOM   2616 C C   . GLN B 1 146 ? 9.274   6.326   33.799 1.000 37.621  0 146 GLN B C   1 ? 
ATOM   2617 O O   . GLN B 1 146 ? 8.407   6.951   33.194 1.000 37.416  0 146 GLN B O   1 ? 
ATOM   2618 C CB  . GLN B 1 146 ? 11.154  5.757   32.263 1.000 41.234  0 146 GLN B CB  1 ? 
ATOM   2619 C CG  . GLN B 1 146 ? 12.307  6.370   31.490 1.000 45.976  0 146 GLN B CG  1 ? 
ATOM   2620 C CD  . GLN B 1 146 ? 12.728  5.481   30.343 1.000 51.352  0 146 GLN B CD  1 ? 
ATOM   2621 O OE1 . GLN B 1 146 ? 12.049  4.517   30.002 1.000 55.632  0 146 GLN B OE1 1 ? 
ATOM   2622 N NE2 . GLN B 1 146 ? 13.871  5.785   29.750 1.000 53.305  0 146 GLN B NE2 1 ? 
ATOM   2623 N N   . ARG B 1 147 ? 9.010   5.428   34.753 1.000 35.346  0 147 ARG B N   1 ? 
ATOM   2624 C CA  . ARG B 1 147 ? 7.650   5.029   35.048 1.000 38.520  0 147 ARG B CA  1 ? 
ATOM   2625 C C   . ARG B 1 147 ? 6.811   6.229   35.457 1.000 41.765  0 147 ARG B C   1 ? 
ATOM   2626 O O   . ARG B 1 147 ? 5.709   6.393   34.969 1.000 36.130  0 147 ARG B O   1 ? 
ATOM   2627 C CB  . ARG B 1 147 ? 7.565   4.033   36.207 1.000 41.108  0 147 ARG B CB  1 ? 
ATOM   2628 C CG  . ARG B 1 147 ? 6.225   3.315   36.284 1.000 40.772  0 147 ARG B CG  1 ? 
ATOM   2629 C CD  . ARG B 1 147 ? 5.959   2.499   35.015 1.000 40.393  0 147 ARG B CD  1 ? 
ATOM   2630 N NE  . ARG B 1 147 ? 4.632   1.899   34.988 1.000 39.284  0 147 ARG B NE  1 ? 
ATOM   2631 C CZ  . ARG B 1 147 ? 3.833   1.829   33.937 1.000 40.045  0 147 ARG B CZ  1 ? 
ATOM   2632 N NH1 . ARG B 1 147 ? 4.178   2.371   32.787 1.000 48.443  0 147 ARG B NH1 1 ? 
ATOM   2633 N NH2 . ARG B 1 147 ? 2.692   1.175   34.026 1.000 47.953  0 147 ARG B NH2 1 ? 
ATOM   2634 N N   . LEU B 1 148 ? 7.331   7.038   36.378 1.000 45.837  0 148 LEU B N   1 ? 
ATOM   2635 C CA  . LEU B 1 148 ? 6.533   8.095   36.989 1.000 47.631  0 148 LEU B CA  1 ? 
ATOM   2636 C C   . LEU B 1 148 ? 5.925   9.000   35.928 1.000 40.926  0 148 LEU B C   1 ? 
ATOM   2637 O O   . LEU B 1 148 ? 4.738   9.272   35.979 1.000 32.627  0 148 LEU B O   1 ? 
ATOM   2638 C CB  . LEU B 1 148 ? 7.388   8.911   37.966 1.000 52.715  0 148 LEU B CB  1 ? 
ATOM   2639 C CG  . LEU B 1 148 ? 7.702   8.235   39.300 1.000 53.023  0 148 LEU B CG  1 ? 
ATOM   2640 C CD1 . LEU B 1 148 ? 8.440   9.201   40.218 1.000 52.650  0 148 LEU B CD1 1 ? 
ATOM   2641 C CD2 . LEU B 1 148 ? 6.431   7.706   39.962 1.000 55.556  0 148 LEU B CD2 1 ? 
ATOM   2642 N N   . PRO B 1 149 ? 6.704   9.564   34.979 1.000 45.740  0 149 PRO B N   1 ? 
ATOM   2643 C CA  . PRO B 1 149 ? 6.118   10.458  33.982 1.000 40.698  0 149 PRO B CA  1 ? 
ATOM   2644 C C   . PRO B 1 149 ? 5.059   9.760   33.140 1.000 34.974  0 149 PRO B C   1 ? 
ATOM   2645 O O   . PRO B 1 149 ? 4.148   10.407  32.660 1.000 38.039  0 149 PRO B O   1 ? 
ATOM   2646 C CB  . PRO B 1 149 ? 7.295   10.968  33.130 1.000 41.766  0 149 PRO B CB  1 ? 
ATOM   2647 C CG  . PRO B 1 149 ? 8.533   10.225  33.620 1.000 44.014  0 149 PRO B CG  1 ? 
ATOM   2648 C CD  . PRO B 1 149 ? 8.173   9.527   34.915 1.000 45.476  0 149 PRO B CD  1 ? 
ATOM   2649 N N   . ARG B 1 150 ? 5.187   8.445   32.951 1.000 35.408  0 150 ARG B N   1 ? 
ATOM   2650 C CA  . ARG B 1 150 ? 4.228   7.680   32.175 1.000 32.173  0 150 ARG B CA  1 ? 
ATOM   2651 C C   . ARG B 1 150 ? 2.909   7.565   32.932 1.000 30.118  0 150 ARG B C   1 ? 
ATOM   2652 O O   . ARG B 1 150 ? 1.848   7.681   32.328 1.000 30.600  0 150 ARG B O   1 ? 
ATOM   2653 C CB  . ARG B 1 150 ? 4.768   6.284   31.920 1.000 36.784  0 150 ARG B CB  1 ? 
ATOM   2654 C CG  . ARG B 1 150 ? 4.183   5.626   30.693 1.000 46.655  0 150 ARG B CG  1 ? 
ATOM   2655 C CD  . ARG B 1 150 ? 4.778   6.206   29.427 1.000 53.218  0 150 ARG B CD  1 ? 
ATOM   2656 N NE  . ARG B 1 150 ? 4.966   5.117   28.477 1.000 57.894  0 150 ARG B NE  1 ? 
ATOM   2657 C CZ  . ARG B 1 150 ? 3.984   4.391   27.956 1.000 57.227  0 150 ARG B CZ  1 ? 
ATOM   2658 N NH1 . ARG B 1 150 ? 2.727   4.766   28.112 1.000 59.374  0 150 ARG B NH1 1 ? 
ATOM   2659 N NH2 . ARG B 1 150 ? 4.268   3.308   27.254 1.000 63.291  0 150 ARG B NH2 1 ? 
ATOM   2660 N N   . TYR B 1 151 ? 2.991   7.327   34.248 1.000 27.086  0 151 TYR B N   1 ? 
ATOM   2661 C CA  . TYR B 1 151 ? 1.820   7.354   35.100 1.000 28.741  0 151 TYR B CA  1 ? 
ATOM   2662 C C   . TYR B 1 151 ? 1.108   8.691   34.925 1.000 29.499  0 151 TYR B C   1 ? 
ATOM   2663 O O   . TYR B 1 151 ? -0.109  8.707   34.698 1.000 30.971  0 151 TYR B O   1 ? 
ATOM   2664 C CB  . TYR B 1 151 ? 2.151   7.128   36.580 1.000 30.712  0 151 TYR B CB  1 ? 
ATOM   2665 C CG  . TYR B 1 151 ? 2.507   5.722   37.006 1.000 34.765  0 151 TYR B CG  1 ? 
ATOM   2666 C CD1 . TYR B 1 151 ? 1.879   4.597   36.486 1.000 35.222  0 151 TYR B CD1 1 ? 
ATOM   2667 C CD2 . TYR B 1 151 ? 3.431   5.518   38.018 1.000 38.825  0 151 TYR B CD2 1 ? 
ATOM   2668 C CE1 . TYR B 1 151 ? 2.182   3.320   36.934 1.000 36.933  0 151 TYR B CE1 1 ? 
ATOM   2669 C CE2 . TYR B 1 151 ? 3.750   4.250   38.474 1.000 37.861  0 151 TYR B CE2 1 ? 
ATOM   2670 C CZ  . TYR B 1 151 ? 3.133   3.143   37.926 1.000 37.254  0 151 TYR B CZ  1 ? 
ATOM   2671 O OH  . TYR B 1 151 ? 3.517   1.899   38.376 1.000 39.773  0 151 TYR B OH  1 ? 
ATOM   2672 N N   . LYS B 1 152 ? 1.873   9.789   35.007 1.000 27.554  0 152 LYS B N   1 ? 
ATOM   2673 C CA  . LYS B 1 152 ? 1.308   11.118  34.900 1.000 32.075  0 152 LYS B CA  1 ? 
ATOM   2674 C C   . LYS B 1 152 ? 0.551   11.200  33.587 1.000 37.686  0 152 LYS B C   1 ? 
ATOM   2675 O O   . LYS B 1 152 ? -0.645  11.521  33.555 1.000 39.879  0 152 LYS B O   1 ? 
ATOM   2676 C CB  . LYS B 1 152 ? 2.391   12.193  34.964 1.000 37.664  0 152 LYS B CB  1 ? 
ATOM   2677 C CG  . LYS B 1 152 ? 1.878   13.619  35.091 1.000 47.080  0 152 LYS B CG  1 ? 
ATOM   2678 C CD  . LYS B 1 152 ? 2.481   14.623  34.092 1.000 52.670  0 152 LYS B CD  1 ? 
ATOM   2679 C CE  . LYS B 1 152 ? 1.734   14.682  32.770 1.000 55.588  0 152 LYS B CE  1 ? 
ATOM   2680 N N   . LEU B 1 153 ? 1.253   10.826  32.513 1.000 37.801  0 153 LEU B N   1 ? 
ATOM   2681 C CA  . LEU B 1 153 ? 0.672   10.863  31.187 1.000 37.012  0 153 LEU B CA  1 ? 
ATOM   2682 C C   . LEU B 1 153 ? -0.629  10.071  31.188 1.000 36.783  0 153 LEU B C   1 ? 
ATOM   2683 O O   . LEU B 1 153 ? -1.686  10.636  30.913 1.000 40.929  0 153 LEU B O   1 ? 
ATOM   2684 C CB  . LEU B 1 153 ? 1.687   10.278  30.201 1.000 39.509  0 153 LEU B CB  1 ? 
ATOM   2685 C CG  . LEU B 1 153 ? 2.037   11.133  28.990 1.000 42.944  0 153 LEU B CG  1 ? 
ATOM   2686 C CD1 . LEU B 1 153 ? 2.124   12.618  29.357 1.000 41.715  0 153 LEU B CD1 1 ? 
ATOM   2687 C CD2 . LEU B 1 153 ? 3.364   10.648  28.420 1.000 46.345  0 153 LEU B CD2 1 ? 
ATOM   2688 N N   . LEU B 1 154 ? -0.510  8.771   31.493 1.000 36.759  0 154 LEU B N   1 ? 
ATOM   2689 C CA  . LEU B 1 154 ? -1.596  7.803   31.404 1.000 37.530  0 154 LEU B CA  1 ? 
ATOM   2690 C C   . LEU B 1 154 ? -2.805  8.252   32.227 1.000 36.998  0 154 LEU B C   1 ? 
ATOM   2691 O O   . LEU B 1 154 ? -3.946  8.179   31.774 1.000 37.130  0 154 LEU B O   1 ? 
ATOM   2692 C CB  . LEU B 1 154 ? -1.090  6.455   31.934 1.000 38.686  0 154 LEU B CB  1 ? 
ATOM   2693 C CG  . LEU B 1 154 ? -0.618  5.394   30.936 1.000 43.537  0 154 LEU B CG  1 ? 
ATOM   2694 C CD1 . LEU B 1 154 ? -0.134  5.985   29.619 1.000 41.666  0 154 LEU B CD1 1 ? 
ATOM   2695 C CD2 . LEU B 1 154 ? 0.483   4.552   31.573 1.000 44.697  0 154 LEU B CD2 1 ? 
ATOM   2696 N N   . LEU B 1 155 ? -2.552  8.691   33.460 1.000 37.949  0 155 LEU B N   1 ? 
ATOM   2697 C CA  . LEU B 1 155 ? -3.638  9.059   34.351 1.000 41.245  0 155 LEU B CA  1 ? 
ATOM   2698 C C   . LEU B 1 155 ? -4.291  10.355  33.897 1.000 41.894  0 155 LEU B C   1 ? 
ATOM   2699 O O   . LEU B 1 155 ? -5.491  10.535  34.077 1.000 49.252  0 155 LEU B O   1 ? 
ATOM   2700 C CB  . LEU B 1 155 ? -3.098  9.193   35.772 1.000 44.916  0 155 LEU B CB  1 ? 
ATOM   2701 C CG  . LEU B 1 155 ? -2.929  7.859   36.490 1.000 53.820  0 155 LEU B CG  1 ? 
ATOM   2702 C CD1 . LEU B 1 155 ? -2.201  8.046   37.816 1.000 57.136  0 155 LEU B CD1 1 ? 
ATOM   2703 C CD2 . LEU B 1 155 ? -4.277  7.175   36.703 1.000 53.041  0 155 LEU B CD2 1 ? 
ATOM   2704 N N   . THR B 1 156 ? -3.504  11.276  33.338 1.000 41.745  0 156 THR B N   1 ? 
ATOM   2705 C CA  . THR B 1 156 ? -4.088  12.522  32.896 1.000 39.268  0 156 THR B CA  1 ? 
ATOM   2706 C C   . THR B 1 156 ? -5.107  12.194  31.811 1.000 39.490  0 156 THR B C   1 ? 
ATOM   2707 O O   . THR B 1 156 ? -6.251  12.614  31.889 1.000 42.250  0 156 THR B O   1 ? 
ATOM   2708 C CB  . THR B 1 156 ? -3.026  13.516  32.429 1.000 40.284  0 156 THR B CB  1 ? 
ATOM   2709 O OG1 . THR B 1 156 ? -2.133  13.830  33.495 1.000 40.583  0 156 THR B OG1 1 ? 
ATOM   2710 C CG2 . THR B 1 156 ? -3.657  14.792  31.923 1.000 40.474  0 156 THR B CG2 1 ? 
ATOM   2711 N N   . ASP B 1 157 ? -4.706  11.384  30.834 1.000 40.525  0 157 ASP B N   1 ? 
ATOM   2712 C CA  . ASP B 1 157 ? -5.572  11.063  29.713 1.000 43.726  0 157 ASP B CA  1 ? 
ATOM   2713 C C   . ASP B 1 157 ? -6.781  10.240  30.175 1.000 42.260  0 157 ASP B C   1 ? 
ATOM   2714 O O   . ASP B 1 157 ? -7.870  10.357  29.612 1.000 46.330  0 157 ASP B O   1 ? 
ATOM   2715 C CB  . ASP B 1 157 ? -4.763  10.374  28.614 1.000 49.553  0 157 ASP B CB  1 ? 
ATOM   2716 C CG  . ASP B 1 157 ? -5.404  10.411  27.229 1.000 57.529  0 157 ASP B CG  1 ? 
ATOM   2717 O OD1 . ASP B 1 157 ? -5.894  11.498  26.823 1.000 69.485  0 157 ASP B OD1 1 ? 
ATOM   2718 O OD2 . ASP B 1 157 ? -5.366  9.362   26.537 1.000 52.418  0 157 ASP B OD2 1 ? 
ATOM   2719 N N   . LEU B 1 158 ? -6.605  9.407   31.201 1.000 35.242  0 158 LEU B N   1 ? 
ATOM   2720 C CA  . LEU B 1 158 ? -7.699  8.594   31.691 1.000 34.155  0 158 LEU B CA  1 ? 
ATOM   2721 C C   . LEU B 1 158 ? -8.734  9.437   32.431 1.000 31.759  0 158 LEU B C   1 ? 
ATOM   2722 O O   . LEU B 1 158 ? -9.928  9.202   32.308 1.000 31.495  0 158 LEU B O   1 ? 
ATOM   2723 C CB  . LEU B 1 158 ? -7.134  7.520   32.617 1.000 39.093  0 158 LEU B CB  1 ? 
ATOM   2724 C CG  . LEU B 1 158 ? -8.145  6.503   33.148 1.000 40.085  0 158 LEU B CG  1 ? 
ATOM   2725 C CD1 . LEU B 1 158 ? -8.661  5.609   32.047 1.000 42.291  0 158 LEU B CD1 1 ? 
ATOM   2726 C CD2 . LEU B 1 158 ? -7.520  5.651   34.237 1.000 42.086  0 158 LEU B CD2 1 ? 
ATOM   2727 N N   . ILE B 1 159 ? -8.284  10.368  33.264 1.000 33.762  0 159 ILE B N   1 ? 
ATOM   2728 C CA  . ILE B 1 159 ? -9.194  11.245  33.983 1.000 38.991  0 159 ILE B CA  1 ? 
ATOM   2729 C C   . ILE B 1 159 ? -10.017 12.077  32.999 1.000 41.766  0 159 ILE B C   1 ? 
ATOM   2730 O O   . ILE B 1 159 ? -11.251 12.086  33.077 1.000 48.918  0 159 ILE B O   1 ? 
ATOM   2731 C CB  . ILE B 1 159 ? -8.435  12.114  34.999 1.000 43.650  0 159 ILE B CB  1 ? 
ATOM   2732 C CG1 . ILE B 1 159 ? -7.992  11.269  36.200 1.000 43.259  0 159 ILE B CG1 1 ? 
ATOM   2733 C CG2 . ILE B 1 159 ? -9.248  13.342  35.428 1.000 41.625  0 159 ILE B CG2 1 ? 
ATOM   2734 C CD1 . ILE B 1 159 ? -6.982  11.990  37.074 1.000 46.014  0 159 ILE B CD1 1 ? 
ATOM   2735 N N   . LYS B 1 160 ? -9.332  12.749  32.066 1.000 40.393  0 160 LYS B N   1 ? 
ATOM   2736 C CA  . LYS B 1 160 ? -9.976  13.561  31.043 1.000 37.633  0 160 LYS B CA  1 ? 
ATOM   2737 C C   . LYS B 1 160 ? -11.110 12.764  30.391 1.000 39.370  0 160 LYS B C   1 ? 
ATOM   2738 O O   . LYS B 1 160 ? -12.107 13.334  29.949 1.000 45.195  0 160 LYS B O   1 ? 
ATOM   2739 C CB  . LYS B 1 160 ? -8.940  14.060  30.025 1.000 35.579  0 160 LYS B CB  1 ? 
ATOM   2740 N N   . HIS B 1 161 ? -10.987 11.436  30.374 1.000 36.789  0 161 HIS B N   1 ? 
ATOM   2741 C CA  . HIS B 1 161 ? -11.946 10.582  29.711 1.000 34.583  0 161 HIS B CA  1 ? 
ATOM   2742 C C   . HIS B 1 161 ? -12.772 9.787   30.706 1.000 36.252  0 161 HIS B C   1 ? 
ATOM   2743 O O   . HIS B 1 161 ? -13.306 8.737   30.332 1.000 33.622  0 161 HIS B O   1 ? 
ATOM   2744 C CB  . HIS B 1 161 ? -11.206 9.688   28.731 1.000 38.654  0 161 HIS B CB  1 ? 
ATOM   2745 C CG  . HIS B 1 161 ? -10.496 10.561  27.757 1.000 47.295  0 161 HIS B CG  1 ? 
ATOM   2746 N ND1 . HIS B 1 161 ? -9.454  11.397  28.102 1.000 48.761  0 161 HIS B ND1 1 ? 
ATOM   2747 C CD2 . HIS B 1 161 ? -10.727 10.763  26.466 1.000 48.205  0 161 HIS B CD2 1 ? 
ATOM   2748 C CE1 . HIS B 1 161 ? -9.049  12.052  27.028 1.000 51.421  0 161 HIS B CE1 1 ? 
ATOM   2749 N NE2 . HIS B 1 161 ? -9.813  11.681  26.026 1.000 55.614  0 161 HIS B NE2 1 ? 
ATOM   2750 N N   . THR B 1 162 ? -12.924 10.328  31.922 1.000 35.745  0 162 THR B N   1 ? 
ATOM   2751 C CA  . THR B 1 162 ? -13.689 9.646   32.953 1.000 39.691  0 162 THR B CA  1 ? 
ATOM   2752 C C   . THR B 1 162 ? -14.745 10.601  33.489 1.000 36.445  0 162 THR B C   1 ? 
ATOM   2753 O O   . THR B 1 162 ? -14.401 11.648  34.020 1.000 31.843  0 162 THR B O   1 ? 
ATOM   2754 C CB  . THR B 1 162 ? -12.763 9.072   34.035 1.000 39.725  0 162 THR B CB  1 ? 
ATOM   2755 O OG1 . THR B 1 162 ? -11.856 8.178   33.384 1.000 38.966  0 162 THR B OG1 1 ? 
ATOM   2756 C CG2 . THR B 1 162 ? -13.512 8.307   35.097 1.000 38.586  0 162 THR B CG2 1 ? 
ATOM   2757 N N   . ASP B 1 163 ? -16.016 10.211  33.312 1.000 40.866  0 163 ASP B N   1 ? 
ATOM   2758 C CA  . ASP B 1 163 ? -17.191 10.969  33.737 1.000 41.498  0 163 ASP B CA  1 ? 
ATOM   2759 C C   . ASP B 1 163 ? -17.259 10.971  35.248 1.000 39.536  0 163 ASP B C   1 ? 
ATOM   2760 O O   . ASP B 1 163 ? -16.765 10.033  35.839 1.000 39.610  0 163 ASP B O   1 ? 
ATOM   2761 C CB  . ASP B 1 163 ? -18.503 10.340  33.233 1.000 40.899  0 163 ASP B CB  1 ? 
ATOM   2762 N N   . ASP B 1 164 ? -17.948 11.954  35.834 1.000 44.898  0 164 ASP B N   1 ? 
ATOM   2763 C CA  . ASP B 1 164 ? -18.076 12.073  37.277 1.000 54.059  0 164 ASP B CA  1 ? 
ATOM   2764 C C   . ASP B 1 164 ? -18.955 10.956  37.837 1.000 57.242  0 164 ASP B C   1 ? 
ATOM   2765 O O   . ASP B 1 164 ? -18.961 10.736  39.047 1.000 55.727  0 164 ASP B O   1 ? 
ATOM   2766 C CB  . ASP B 1 164 ? -18.663 13.425  37.701 1.000 59.385  0 164 ASP B CB  1 ? 
ATOM   2767 C CG  . ASP B 1 164 ? -17.760 14.612  37.423 1.000 66.983  0 164 ASP B CG  1 ? 
ATOM   2768 O OD1 . ASP B 1 164 ? -16.585 14.394  37.048 1.000 68.741  0 164 ASP B OD1 1 ? 
ATOM   2769 O OD2 . ASP B 1 164 ? -18.249 15.741  37.559 1.000 72.275  0 164 ASP B OD2 1 ? 
ATOM   2770 N N   . ASP B 1 165 ? -19.696 10.248  36.968 1.000 61.554  0 165 ASP B N   1 ? 
ATOM   2771 C CA  . ASP B 1 165 ? -20.585 9.183   37.421 1.000 67.245  0 165 ASP B CA  1 ? 
ATOM   2772 C C   . ASP B 1 165 ? -19.801 7.909   37.751 1.000 69.480  0 165 ASP B C   1 ? 
ATOM   2773 O O   . ASP B 1 165 ? -20.327 7.055   38.468 1.000 72.123  0 165 ASP B O   1 ? 
ATOM   2774 C CB  . ASP B 1 165 ? -21.721 8.947   36.421 1.000 66.836  0 165 ASP B CB  1 ? 
ATOM   2775 C CG  . ASP B 1 165 ? -22.804 10.027  36.423 1.000 72.171  0 165 ASP B CG  1 ? 
ATOM   2776 O OD1 . ASP B 1 165 ? -22.739 10.969  37.262 1.000 79.947  0 165 ASP B OD1 1 ? 
ATOM   2777 O OD2 . ASP B 1 165 ? -23.723 9.935   35.576 1.000 63.673  0 165 ASP B OD2 1 ? 
ATOM   2778 N N   . PHE B 1 166 ? -18.553 7.793   37.245 1.000 67.189  0 166 PHE B N   1 ? 
ATOM   2779 C CA  . PHE B 1 166 ? -17.582 6.810   37.725 1.000 57.737  0 166 PHE B CA  1 ? 
ATOM   2780 C C   . PHE B 1 166 ? -17.236 7.125   39.186 1.000 55.714  0 166 PHE B C   1 ? 
ATOM   2781 O O   . PHE B 1 166 ? -16.851 8.266   39.501 1.000 52.151  0 166 PHE B O   1 ? 
ATOM   2782 C CB  . PHE B 1 166 ? -16.288 6.807   36.896 1.000 54.016  0 166 PHE B CB  1 ? 
ATOM   2783 C CG  . PHE B 1 166 ? -16.348 6.215   35.507 1.000 57.090  0 166 PHE B CG  1 ? 
ATOM   2784 C CD1 . PHE B 1 166 ? -16.698 6.993   34.409 1.000 58.452  0 166 PHE B CD1 1 ? 
ATOM   2785 C CD2 . PHE B 1 166 ? -16.023 4.880   35.283 1.000 58.099  0 166 PHE B CD2 1 ? 
ATOM   2786 C CE1 . PHE B 1 166 ? -16.726 6.449   33.129 1.000 60.076  0 166 PHE B CE1 1 ? 
ATOM   2787 C CE2 . PHE B 1 166 ? -16.050 4.339   34.004 1.000 55.306  0 166 PHE B CE2 1 ? 
ATOM   2788 C CZ  . PHE B 1 166 ? -16.400 5.123   32.928 1.000 59.079  0 166 PHE B CZ  1 ? 
ATOM   2789 N N   . VAL B 1 167 ? -17.396 6.116   40.066 1.000 45.962  0 167 VAL B N   1 ? 
ATOM   2790 C CA  . VAL B 1 167 ? -17.185 6.287   41.501 1.000 49.784  0 167 VAL B CA  1 ? 
ATOM   2791 C C   . VAL B 1 167 ? -15.682 6.347   41.770 1.000 40.963  0 167 VAL B C   1 ? 
ATOM   2792 O O   . VAL B 1 167 ? -15.239 6.960   42.739 1.000 35.539  0 167 VAL B O   1 ? 
ATOM   2793 C CB  . VAL B 1 167 ? -17.874 5.175   42.327 1.000 48.115  0 167 VAL B CB  1 ? 
ATOM   2794 N N   . ASP B 1 168 ? -14.927 5.731   40.850 1.000 40.884  0 168 ASP B N   1 ? 
ATOM   2795 C CA  . ASP B 1 168 ? -13.483 5.578   40.931 1.000 44.348  0 168 ASP B CA  1 ? 
ATOM   2796 C C   . ASP B 1 168 ? -12.733 6.886   40.630 1.000 41.708  0 168 ASP B C   1 ? 
ATOM   2797 O O   . ASP B 1 168 ? -11.532 6.957   40.852 1.000 40.031  0 168 ASP B O   1 ? 
ATOM   2798 C CB  . ASP B 1 168 ? -13.045 4.473   39.966 1.000 44.150  0 168 ASP B CB  1 ? 
ATOM   2799 C CG  . ASP B 1 168 ? -11.732 3.781   40.317 1.000 51.351  0 168 ASP B CG  1 ? 
ATOM   2800 O OD1 . ASP B 1 168 ? -11.594 3.313   41.481 1.000 53.469  0 168 ASP B OD1 1 ? 
ATOM   2801 O OD2 . ASP B 1 168 ? -10.865 3.671   39.410 1.000 56.348  0 168 ASP B OD2 1 ? 
ATOM   2802 N N   . LYS B 1 169 ? -13.420 7.915   40.125 1.000 40.626  0 169 LYS B N   1 ? 
ATOM   2803 C CA  . LYS B 1 169 ? -12.728 9.043   39.532 1.000 45.683  0 169 LYS B CA  1 ? 
ATOM   2804 C C   . LYS B 1 169 ? -11.889 9.767   40.581 1.000 45.081  0 169 LYS B C   1 ? 
ATOM   2805 O O   . LYS B 1 169 ? -10.726 10.060  40.345 1.000 42.814  0 169 LYS B O   1 ? 
ATOM   2806 C CB  . LYS B 1 169 ? -13.698 10.017  38.865 1.000 44.547  0 169 LYS B CB  1 ? 
ATOM   2807 C CG  . LYS B 1 169 ? -13.018 11.162  38.142 1.000 46.303  0 169 LYS B CG  1 ? 
ATOM   2808 C CD  . LYS B 1 169 ? -13.961 12.206  37.635 1.000 54.504  0 169 LYS B CD  1 ? 
ATOM   2809 C CE  . LYS B 1 169 ? -13.338 13.124  36.603 1.000 59.599  0 169 LYS B CE  1 ? 
ATOM   2810 N NZ  . LYS B 1 169 ? -14.373 13.882  35.860 1.000 55.375  0 169 LYS B NZ  1 ? 
ATOM   2811 N N   . PRO B 1 170 ? -12.423 10.077  41.777 1.000 48.416  0 170 PRO B N   1 ? 
ATOM   2812 C CA  . PRO B 1 170 ? -11.621 10.741  42.810 1.000 47.506  0 170 PRO B CA  1 ? 
ATOM   2813 C C   . PRO B 1 170 ? -10.344 9.972   43.150 1.000 42.560  0 170 PRO B C   1 ? 
ATOM   2814 O O   . PRO B 1 170 ? -9.287  10.575  43.302 1.000 36.413  0 170 PRO B O   1 ? 
ATOM   2815 C CB  . PRO B 1 170 ? -12.569 10.806  44.019 1.000 49.952  0 170 PRO B CB  1 ? 
ATOM   2816 C CG  . PRO B 1 170 ? -13.951 10.695  43.405 1.000 51.538  0 170 PRO B CG  1 ? 
ATOM   2817 C CD  . PRO B 1 170 ? -13.784 9.756   42.230 1.000 51.255  0 170 PRO B CD  1 ? 
ATOM   2818 N N   . LYS B 1 171 ? -10.454 8.638   43.231 1.000 42.102  0 171 LYS B N   1 ? 
ATOM   2819 C CA  . LYS B 1 171 ? -9.302  7.768   43.442 1.000 44.746  0 171 LYS B CA  1 ? 
ATOM   2820 C C   . LYS B 1 171 ? -8.211  7.964   42.376 1.000 43.274  0 171 LYS B C   1 ? 
ATOM   2821 O O   . LYS B 1 171 ? -7.023  7.985   42.697 1.000 48.255  0 171 LYS B O   1 ? 
ATOM   2822 C CB  . LYS B 1 171 ? -9.720  6.292   43.475 1.000 51.261  0 171 LYS B CB  1 ? 
ATOM   2823 C CG  . LYS B 1 171 ? -10.812 5.939   44.472 1.000 53.698  0 171 LYS B CG  1 ? 
ATOM   2824 C CD  . LYS B 1 171 ? -10.838 4.473   44.806 1.000 53.639  0 171 LYS B CD  1 ? 
ATOM   2825 C CE  . LYS B 1 171 ? -11.853 4.168   45.883 1.000 52.544  0 171 LYS B CE  1 ? 
ATOM   2826 N NZ  . LYS B 1 171 ? -13.223 4.134   45.338 1.000 51.195  0 171 LYS B NZ  1 ? 
ATOM   2827 N N   . LEU B 1 172 ? -8.595  8.107   41.104 1.000 40.940  0 172 LEU B N   1 ? 
ATOM   2828 C CA  . LEU B 1 172 ? -7.638  8.438   40.055 1.000 37.211  0 172 LEU B CA  1 ? 
ATOM   2829 C C   . LEU B 1 172 ? -7.064  9.834   40.275 1.000 40.030  0 172 LEU B C   1 ? 
ATOM   2830 O O   . LEU B 1 172 ? -5.889  10.048  40.022 1.000 44.501  0 172 LEU B O   1 ? 
ATOM   2831 C CB  . LEU B 1 172 ? -8.301  8.353   38.683 1.000 33.018  0 172 LEU B CB  1 ? 
ATOM   2832 C CG  . LEU B 1 172 ? -9.072  7.067   38.400 1.000 32.234  0 172 LEU B CG  1 ? 
ATOM   2833 C CD1 . LEU B 1 172 ? -9.754  7.156   37.049 1.000 35.454  0 172 LEU B CD1 1 ? 
ATOM   2834 C CD2 . LEU B 1 172 ? -8.176  5.841   38.474 1.000 31.698  0 172 LEU B CD2 1 ? 
ATOM   2835 N N   . ILE B 1 173 ? -7.868  10.783  40.755 1.000 42.355  0 173 ILE B N   1 ? 
ATOM   2836 C CA  . ILE B 1 173 ? -7.394  12.148  40.919 1.000 46.632  0 173 ILE B CA  1 ? 
ATOM   2837 C C   . ILE B 1 173 ? -6.347  12.216  42.031 1.000 42.022  0 173 ILE B C   1 ? 
ATOM   2838 O O   . ILE B 1 173 ? -5.295  12.808  41.857 1.000 38.516  0 173 ILE B O   1 ? 
ATOM   2839 C CB  . ILE B 1 173 ? -8.587  13.095  41.163 1.000 54.987  0 173 ILE B CB  1 ? 
ATOM   2840 C CG1 . ILE B 1 173 ? -9.478  13.166  39.919 1.000 57.225  0 173 ILE B CG1 1 ? 
ATOM   2841 C CG2 . ILE B 1 173 ? -8.120  14.475  41.603 1.000 53.782  0 173 ILE B CG2 1 ? 
ATOM   2842 C CD1 . ILE B 1 173 ? -10.893 13.655  40.185 1.000 63.064  0 173 ILE B CD1 1 ? 
ATOM   2843 N N   . ASP B 1 174 ? -6.652  11.633  43.188 1.000 48.240  0 174 ASP B N   1 ? 
ATOM   2844 C CA  . ASP B 1 174 ? -5.698  11.493  44.273 1.000 47.815  0 174 ASP B CA  1 ? 
ATOM   2845 C C   . ASP B 1 174 ? -4.369  10.985  43.717 1.000 46.832  0 174 ASP B C   1 ? 
ATOM   2846 O O   . ASP B 1 174 ? -3.315  11.577  43.959 1.000 41.392  0 174 ASP B O   1 ? 
ATOM   2847 C CB  . ASP B 1 174 ? -6.231  10.514  45.320 1.000 56.645  0 174 ASP B CB  1 ? 
ATOM   2848 C CG  . ASP B 1 174 ? -5.469  10.521  46.636 1.000 72.526  0 174 ASP B CG  1 ? 
ATOM   2849 O OD1 . ASP B 1 174 ? -4.716  11.491  46.869 1.000 82.846  0 174 ASP B OD1 1 ? 
ATOM   2850 O OD2 . ASP B 1 174 ? -5.627  9.551   47.421 1.000 77.115  0 174 ASP B OD2 1 ? 
ATOM   2851 N N   . ALA B 1 175 ? -4.427  9.890   42.954 1.000 39.204  0 175 ALA B N   1 ? 
ATOM   2852 C CA  . ALA B 1 175 ? -3.218  9.262   42.451 1.000 40.140  0 175 ALA B CA  1 ? 
ATOM   2853 C C   . ALA B 1 175 ? -2.420  10.249  41.605 1.000 39.838  0 175 ALA B C   1 ? 
ATOM   2854 O O   . ALA B 1 175 ? -1.233  10.465  41.844 1.000 43.049  0 175 ALA B O   1 ? 
ATOM   2855 C CB  . ALA B 1 175 ? -3.556  7.995   41.698 1.000 38.388  0 175 ALA B CB  1 ? 
ATOM   2856 N N   . LEU B 1 176 ? -3.074  10.870  40.629 1.000 40.486  0 176 LEU B N   1 ? 
ATOM   2857 C CA  . LEU B 1 176 ? -2.364  11.804  39.775 1.000 45.973  0 176 LEU B CA  1 ? 
ATOM   2858 C C   . LEU B 1 176 ? -1.764  12.925  40.639 1.000 51.287  0 176 LEU B C   1 ? 
ATOM   2859 O O   . LEU B 1 176 ? -0.618  13.324  40.420 1.000 53.458  0 176 LEU B O   1 ? 
ATOM   2860 C CB  . LEU B 1 176 ? -3.308  12.317  38.679 1.000 46.575  0 176 LEU B CB  1 ? 
ATOM   2861 C CG  . LEU B 1 176 ? -2.723  13.340  37.697 1.000 54.665  0 176 LEU B CG  1 ? 
ATOM   2862 C CD1 . LEU B 1 176 ? -1.576  12.750  36.886 1.000 50.716  0 176 LEU B CD1 1 ? 
ATOM   2863 C CD2 . LEU B 1 176 ? -3.797  13.866  36.749 1.000 57.727  0 176 LEU B CD2 1 ? 
ATOM   2864 N N   . ASP B 1 177 ? -2.491  13.378  41.671 1.000 43.424  0 177 ASP B N   1 ? 
ATOM   2865 C CA  . ASP B 1 177 ? -1.984  14.447  42.515 1.000 50.242  0 177 ASP B CA  1 ? 
ATOM   2866 C C   . ASP B 1 177 ? -0.655  14.059  43.165 1.000 51.222  0 177 ASP B C   1 ? 
ATOM   2867 O O   . ASP B 1 177 ? 0.265   14.875  43.205 1.000 55.445  0 177 ASP B O   1 ? 
ATOM   2868 C CB  . ASP B 1 177 ? -2.955  14.862  43.621 1.000 56.052  0 177 ASP B CB  1 ? 
ATOM   2869 C CG  . ASP B 1 177 ? -2.260  15.624  44.741 1.000 62.507  0 177 ASP B CG  1 ? 
ATOM   2870 O OD1 . ASP B 1 177 ? -1.782  16.753  44.475 1.000 70.353  0 177 ASP B OD1 1 ? 
ATOM   2871 O OD2 . ASP B 1 177 ? -2.163  15.071  45.863 1.000 65.607  0 177 ASP B OD2 1 ? 
ATOM   2872 N N   . LYS B 1 178 ? -0.560  12.837  43.704 1.000 48.226  0 178 LYS B N   1 ? 
ATOM   2873 C CA  . LYS B 1 178 ? 0.613   12.460  44.471 1.000 47.888  0 178 LYS B CA  1 ? 
ATOM   2874 C C   . LYS B 1 178 ? 1.741   12.021  43.539 1.000 47.209  0 178 LYS B C   1 ? 
ATOM   2875 O O   . LYS B 1 178 ? 2.913   12.251  43.833 1.000 51.848  0 178 LYS B O   1 ? 
ATOM   2876 C CB  . LYS B 1 178 ? 0.294   11.342  45.465 1.000 53.547  0 178 LYS B CB  1 ? 
ATOM   2877 C CG  . LYS B 1 178 ? -0.773  11.645  46.511 1.000 57.925  0 178 LYS B CG  1 ? 
ATOM   2878 C CD  . LYS B 1 178 ? -0.575  10.875  47.818 1.000 70.331  0 178 LYS B CD  1 ? 
ATOM   2879 C CE  . LYS B 1 178 ? -1.824  10.233  48.408 1.000 82.851  0 178 LYS B CE  1 ? 
ATOM   2880 N NZ  . LYS B 1 178 ? -2.777  11.224  48.965 1.000 84.947  0 178 LYS B NZ  1 ? 
ATOM   2881 N N   . ILE B 1 179 ? 1.395   11.360  42.432 1.000 45.377  0 179 ILE B N   1 ? 
ATOM   2882 C CA  . ILE B 1 179 ? 2.396   10.928  41.477 1.000 45.499  0 179 ILE B CA  1 ? 
ATOM   2883 C C   . ILE B 1 179 ? 3.039   12.168  40.871 1.000 43.197  0 179 ILE B C   1 ? 
ATOM   2884 O O   . ILE B 1 179 ? 4.249   12.232  40.730 1.000 41.643  0 179 ILE B O   1 ? 
ATOM   2885 C CB  . ILE B 1 179 ? 1.793   9.985   40.412 1.000 48.159  0 179 ILE B CB  1 ? 
ATOM   2886 C CG1 . ILE B 1 179 ? 1.988   8.513   40.776 1.000 51.431  0 179 ILE B CG1 1 ? 
ATOM   2887 C CG2 . ILE B 1 179 ? 2.355   10.260  39.024 1.000 56.409  0 179 ILE B CG2 1 ? 
ATOM   2888 C CD1 . ILE B 1 179 ? 0.824   7.913   41.503 1.000 62.053  0 179 ILE B CD1 1 ? 
ATOM   2889 N N   . SER B 1 180 ? 2.209   13.143  40.505 1.000 48.388  0 180 SER B N   1 ? 
ATOM   2890 C CA  . SER B 1 180 ? 2.713   14.387  39.963 1.000 54.216  0 180 SER B CA  1 ? 
ATOM   2891 C C   . SER B 1 180 ? 3.709   15.034  40.929 1.000 53.236  0 180 SER B C   1 ? 
ATOM   2892 O O   . SER B 1 180 ? 4.683   15.639  40.494 1.000 53.753  0 180 SER B O   1 ? 
ATOM   2893 C CB  . SER B 1 180 ? 1.591   15.306  39.579 1.000 59.151  0 180 SER B CB  1 ? 
ATOM   2894 O OG  . SER B 1 180 ? 0.791   15.615  40.705 1.000 68.607  0 180 SER B OG  1 ? 
ATOM   2895 N N   . LYS B 1 181 ? 3.515   14.873  42.236 1.000 53.853  0 181 LYS B N   1 ? 
ATOM   2896 C CA  . LYS B 1 181 ? 4.432   15.465  43.196 1.000 61.479  0 181 LYS B CA  1 ? 
ATOM   2897 C C   . LYS B 1 181 ? 5.871   14.971  42.994 1.000 61.598  0 181 LYS B C   1 ? 
ATOM   2898 O O   . LYS B 1 181 ? 6.773   15.564  43.570 1.000 60.117  0 181 LYS B O   1 ? 
ATOM   2899 C CB  . LYS B 1 181 ? 3.956   15.212  44.633 1.000 62.597  0 181 LYS B CB  1 ? 
ATOM   2900 N N   . LEU B 1 182 ? 6.125   13.914  42.203 1.000 57.099  0 182 LEU B N   1 ? 
ATOM   2901 C CA  . LEU B 1 182 ? 7.494   13.481  41.960 1.000 58.850  0 182 LEU B CA  1 ? 
ATOM   2902 C C   . LEU B 1 182 ? 7.976   13.941  40.585 1.000 67.450  0 182 LEU B C   1 ? 
ATOM   2903 O O   . LEU B 1 182 ? 8.558   13.174  39.823 1.000 63.084  0 182 LEU B O   1 ? 
ATOM   2904 C CB  . LEU B 1 182 ? 7.592   11.967  42.123 1.000 61.807  0 182 LEU B CB  1 ? 
ATOM   2905 C CG  . LEU B 1 182 ? 7.127   11.451  43.484 1.000 60.105  0 182 LEU B CG  1 ? 
ATOM   2906 C CD1 . LEU B 1 182 ? 5.799   10.706  43.369 1.000 62.449  0 182 LEU B CD1 1 ? 
ATOM   2907 C CD2 . LEU B 1 182 ? 8.208   10.596  44.134 1.000 56.421  0 182 LEU B CD2 1 ? 
ATOM   2908 N N   . ALA B 1 183 ? 7.798   15.243  40.328 1.000 75.366  0 183 ALA B N   1 ? 
ATOM   2909 C CA  . ALA B 1 183 ? 8.213   15.907  39.105 1.000 68.556  0 183 ALA B CA  1 ? 
ATOM   2910 C C   . ALA B 1 183 ? 9.717   16.200  39.109 1.000 80.382  0 183 ALA B C   1 ? 
ATOM   2911 O O   . ALA B 1 183 ? 10.242  16.787  38.162 1.000 84.614  0 183 ALA B O   1 ? 
ATOM   2912 C CB  . ALA B 1 183 ? 7.424   17.186  38.992 1.000 70.011  0 183 ALA B CB  1 ? 
ATOM   2913 N N   . THR B 1 184 ? 10.418  15.792  40.177 1.000 84.607  0 184 THR B N   1 ? 
ATOM   2914 C CA  . THR B 1 184 ? 11.865  15.927  40.278 1.000 69.462  0 184 THR B CA  1 ? 
ATOM   2915 C C   . THR B 1 184 ? 12.603  14.952  39.347 1.000 64.146  0 184 THR B C   1 ? 
ATOM   2916 O O   . THR B 1 184 ? 13.830  15.019  39.260 1.000 81.098  0 184 THR B O   1 ? 
ATOM   2917 C CB  . THR B 1 184 ? 12.323  15.797  41.744 1.000 65.100  0 184 THR B CB  1 ? 
ATOM   2918 O OG1 . THR B 1 184 ? 13.718  16.104  41.732 1.000 77.923  0 184 THR B OG1 1 ? 
ATOM   2919 C CG2 . THR B 1 184 ? 12.104  14.441  42.393 1.000 56.116  0 184 THR B CG2 1 ? 
ATOM   2920 N N   . LEU B 1 185 ? 11.884  14.064  38.642 1.000 58.322  0 185 LEU B N   1 ? 
ATOM   2921 C CA  . LEU B 1 185 ? 12.482  13.153  37.669 1.000 60.491  0 185 LEU B CA  1 ? 
ATOM   2922 C C   . LEU B 1 185 ? 13.307  13.937  36.645 1.000 66.615  0 185 LEU B C   1 ? 
ATOM   2923 O O   . LEU B 1 185 ? 14.333  13.448  36.157 1.000 56.763  0 185 LEU B O   1 ? 
ATOM   2924 C CB  . LEU B 1 185 ? 11.391  12.341  36.956 1.000 50.802  0 185 LEU B CB  1 ? 
ATOM   2925 N N   . VAL B 1 186 ? 12.860  15.164  36.348 1.000 62.005  0 186 VAL B N   1 ? 
ATOM   2926 C CA  . VAL B 1 186 ? 13.506  15.994  35.346 1.000 65.074  0 186 VAL B CA  1 ? 
ATOM   2927 C C   . VAL B 1 186 ? 14.899  16.373  35.851 1.000 63.663  0 186 VAL B C   1 ? 
ATOM   2928 O O   . VAL B 1 186 ? 15.889  16.296  35.114 1.000 61.220  0 186 VAL B O   1 ? 
ATOM   2929 C CB  . VAL B 1 186 ? 12.644  17.232  35.032 1.000 76.770  0 186 VAL B CB  1 ? 
ATOM   2930 C CG1 . VAL B 1 186 ? 13.204  18.036  33.864 1.000 82.394  0 186 VAL B CG1 1 ? 
ATOM   2931 C CG2 . VAL B 1 186 ? 11.179  16.863  34.782 1.000 76.135  0 186 VAL B CG2 1 ? 
ATOM   2932 N N   . ASN B 1 187 ? 14.970  16.730  37.141 1.000 61.026  0 187 ASN B N   1 ? 
ATOM   2933 C CA  . ASN B 1 187 ? 16.240  17.030  37.786 1.000 52.482  0 187 ASN B CA  1 ? 
ATOM   2934 C C   . ASN B 1 187 ? 17.129  15.789  37.704 1.000 52.887  0 187 ASN B C   1 ? 
ATOM   2935 O O   . ASN B 1 187 ? 18.328  15.929  37.457 1.000 45.266  0 187 ASN B O   1 ? 
ATOM   2936 C CB  . ASN B 1 187 ? 16.052  17.557  39.214 1.000 47.481  0 187 ASN B CB  1 ? 
ATOM   2937 N N   . GLU B 1 188 ? 16.526  14.594  37.880 1.000 53.565  0 188 GLU B N   1 ? 
ATOM   2938 C CA  . GLU B 1 188 ? 17.277  13.342  37.884 1.000 53.260  0 188 GLU B CA  1 ? 
ATOM   2939 C C   . GLU B 1 188 ? 17.781  13.043  36.470 1.000 46.022  0 188 GLU B C   1 ? 
ATOM   2940 O O   . GLU B 1 188 ? 18.956  12.757  36.287 1.000 40.164  0 188 GLU B O   1 ? 
ATOM   2941 C CB  . GLU B 1 188 ? 16.470  12.179  38.477 1.000 47.993  0 188 GLU B CB  1 ? 
ATOM   2942 N N   . VAL B 1 189 ? 16.905  13.170  35.469 1.000 50.126  0 189 VAL B N   1 ? 
ATOM   2943 C CA  . VAL B 1 189 ? 17.290  12.972  34.078 1.000 50.641  0 189 VAL B CA  1 ? 
ATOM   2944 C C   . VAL B 1 189 ? 18.464  13.896  33.742 1.000 55.014  0 189 VAL B C   1 ? 
ATOM   2945 O O   . VAL B 1 189 ? 19.484  13.438  33.224 1.000 60.186  0 189 VAL B O   1 ? 
ATOM   2946 C CB  . VAL B 1 189 ? 16.092  13.167  33.128 1.000 53.886  0 189 VAL B CB  1 ? 
ATOM   2947 C CG1 . VAL B 1 189 ? 16.533  13.384  31.690 1.000 59.947  0 189 VAL B CG1 1 ? 
ATOM   2948 C CG2 . VAL B 1 189 ? 15.103  12.009  33.191 1.000 51.462  0 189 VAL B CG2 1 ? 
ATOM   2949 N N   . ILE B 1 190 ? 18.343  15.181  34.100 1.000 56.388  0 190 ILE B N   1 ? 
ATOM   2950 C CA  . ILE B 1 190 ? 19.381  16.155  33.806 1.000 57.787  0 190 ILE B CA  1 ? 
ATOM   2951 C C   . ILE B 1 190 ? 20.714  15.688  34.392 1.000 57.007  0 190 ILE B C   1 ? 
ATOM   2952 O O   . ILE B 1 190 ? 21.718  15.650  33.675 1.000 60.159  0 190 ILE B O   1 ? 
ATOM   2953 C CB  . ILE B 1 190 ? 18.996  17.570  34.288 1.000 63.471  0 190 ILE B CB  1 ? 
ATOM   2954 N N   . LYS B 1 191 ? 20.722  15.301  35.674 1.000 51.971  0 191 LYS B N   1 ? 
ATOM   2955 C CA  . LYS B 1 191 ? 21.971  15.059  36.380 1.000 48.030  0 191 LYS B CA  1 ? 
ATOM   2956 C C   . LYS B 1 191 ? 22.607  13.773  35.856 1.000 47.360  0 191 LYS B C   1 ? 
ATOM   2957 O O   . LYS B 1 191 ? 23.829  13.714  35.781 1.000 48.576  0 191 LYS B O   1 ? 
ATOM   2958 C CB  . LYS B 1 191 ? 21.752  15.056  37.896 1.000 43.592  0 191 LYS B CB  1 ? 
ATOM   2959 N N   . GLU B 1 192 ? 21.786  12.791  35.437 1.000 45.857  0 192 GLU B N   1 ? 
ATOM   2960 C CA  . GLU B 1 192 ? 22.275  11.555  34.828 1.000 44.428  0 192 GLU B CA  1 ? 
ATOM   2961 C C   . GLU B 1 192 ? 22.916  11.850  33.469 1.000 46.317  0 192 GLU B C   1 ? 
ATOM   2962 O O   . GLU B 1 192 ? 23.955  11.271  33.147 1.000 44.032  0 192 GLU B O   1 ? 
ATOM   2963 C CB  . GLU B 1 192 ? 21.148  10.526  34.695 1.000 35.956  0 192 GLU B CB  1 ? 
ATOM   2964 N N   . ARG B 1 193 ? 22.318  12.793  32.719 1.000 45.736  0 193 ARG B N   1 ? 
ATOM   2965 C CA  . ARG B 1 193 ? 22.846  13.217  31.432 1.000 49.918  0 193 ARG B CA  1 ? 
ATOM   2966 C C   . ARG B 1 193 ? 24.279  13.727  31.613 1.000 53.311  0 193 ARG B C   1 ? 
ATOM   2967 O O   . ARG B 1 193 ? 25.218  13.189  31.016 1.000 45.494  0 193 ARG B O   1 ? 
ATOM   2968 C CB  . ARG B 1 193 ? 21.934  14.278  30.797 1.000 53.651  0 193 ARG B CB  1 ? 
ATOM   2969 C CG  . ARG B 1 193 ? 22.155  14.475  29.296 1.000 56.909  0 193 ARG B CG  1 ? 
ATOM   2970 N N   . SER B 1 194 ? 24.433  14.706  32.528 1.000 56.670  0 194 SER B N   1 ? 
ATOM   2971 C CA  . SER B 1 194 ? 25.698  15.402  32.730 1.000 60.949  0 194 SER B CA  1 ? 
ATOM   2972 C C   . SER B 1 194 ? 26.802  14.396  33.039 1.000 61.504  0 194 SER B C   1 ? 
ATOM   2973 O O   . SER B 1 194 ? 27.876  14.477  32.446 1.000 66.280  0 194 SER B O   1 ? 
ATOM   2974 C CB  . SER B 1 194 ? 25.636  16.439  33.835 1.000 66.505  0 194 SER B CB  1 ? 
ATOM   2975 O OG  . SER B 1 194 ? 24.426  17.186  33.803 1.000 78.775  0 194 SER B OG  1 ? 
ATOM   2976 N N   . ARG B 1 195 ? 26.529  13.481  33.985 1.000 56.577  0 195 ARG B N   1 ? 
ATOM   2977 C CA  . ARG B 1 195 ? 27.526  12.532  34.469 1.000 55.562  0 195 ARG B CA  1 ? 
ATOM   2978 C C   . ARG B 1 195 ? 27.974  11.621  33.320 1.000 49.010  0 195 ARG B C   1 ? 
ATOM   2979 O O   . ARG B 1 195 ? 29.168  11.419  33.140 1.000 41.878  0 195 ARG B O   1 ? 
ATOM   2980 C CB  . ARG B 1 195 ? 26.989  11.750  35.677 1.000 51.955  0 195 ARG B CB  1 ? 
ATOM   2981 N N   . ASN B 1 196 ? 27.014  11.161  32.505 1.000 46.208  0 196 ASN B N   1 ? 
ATOM   2982 C CA  . ASN B 1 196 ? 27.256  10.253  31.393 1.000 47.132  0 196 ASN B CA  1 ? 
ATOM   2983 C C   . ASN B 1 196 ? 28.114  10.922  30.309 1.000 47.516  0 196 ASN B C   1 ? 
ATOM   2984 O O   . ASN B 1 196 ? 28.804  10.279  29.518 1.000 51.847  0 196 ASN B O   1 ? 
ATOM   2985 C CB  . ASN B 1 196 ? 25.927  9.768   30.800 1.000 46.422  0 196 ASN B CB  1 ? 
ATOM   2986 C CG  . ASN B 1 196 ? 25.810  8.260   30.734 1.000 54.088  0 196 ASN B CG  1 ? 
ATOM   2987 O OD1 . ASN B 1 196 ? 26.752  7.572   30.351 1.000 58.628  0 196 ASN B OD1 1 ? 
ATOM   2988 N ND2 . ASN B 1 196 ? 24.660  7.731   31.126 1.000 59.531  0 196 ASN B ND2 1 ? 
ATOM   2989 N N   . GLN B 1 197 ? 28.081  12.240  30.243 1.000 45.955  0 197 GLN B N   1 ? 
ATOM   2990 C CA  . GLN B 1 197 ? 28.732  12.907  29.139 1.000 49.929  0 197 GLN B CA  1 ? 
ATOM   2991 C C   . GLN B 1 197 ? 29.866  13.802  29.632 1.000 50.911  0 197 GLN B C   1 ? 
ATOM   2992 O O   . GLN B 1 197 ? 30.437  14.523  28.828 1.000 53.654  0 197 GLN B O   1 ? 
ATOM   2993 C CB  . GLN B 1 197 ? 27.627  13.635  28.385 1.000 54.010  0 197 GLN B CB  1 ? 
ATOM   2994 C CG  . GLN B 1 197 ? 26.413  12.732  28.255 1.000 63.489  0 197 GLN B CG  1 ? 
ATOM   2995 C CD  . GLN B 1 197 ? 25.258  13.360  27.538 1.000 70.652  0 197 GLN B CD  1 ? 
ATOM   2996 O OE1 . GLN B 1 197 ? 24.973  14.549  27.674 1.000 104.627 0 197 GLN B OE1 1 ? 
ATOM   2997 N NE2 . GLN B 1 197 ? 24.618  12.550  26.718 1.000 69.824  0 197 GLN B NE2 1 ? 
ATOM   2998 N N   . LYS B 1 198 ? 30.215  13.728  30.926 1.000 46.030  0 198 LYS B N   1 ? 
ATOM   2999 C CA  . LYS B 1 198 ? 31.199  14.628  31.496 1.000 48.873  0 198 LYS B CA  1 ? 
ATOM   3000 C C   . LYS B 1 198 ? 32.533  14.480  30.779 1.000 46.991  0 198 LYS B C   1 ? 
ATOM   3001 O O   . LYS B 1 198 ? 33.249  15.464  30.629 1.000 48.257  0 198 LYS B O   1 ? 
ATOM   3002 C CB  . LYS B 1 198 ? 31.396  14.402  33.001 1.000 56.432  0 198 LYS B CB  1 ? 
ATOM   3003 C CG  . LYS B 1 198 ? 30.884  15.520  33.910 1.000 62.320  0 198 LYS B CG  1 ? 
ATOM   3004 C CD  . LYS B 1 198 ? 31.912  16.567  34.312 1.000 66.255  0 198 LYS B CD  1 ? 
ATOM   3005 C CE  . LYS B 1 198 ? 32.477  16.389  35.711 1.000 75.058  0 198 LYS B CE  1 ? 
ATOM   3006 N NZ  . LYS B 1 198 ? 33.456  15.275  35.806 1.000 83.015  0 198 LYS B NZ  1 ? 
ATOM   3007 N N   . LEU B 1 199 ? 32.865  13.261  30.351 1.000 48.882  0 199 LEU B N   1 ? 
ATOM   3008 C CA  . LEU B 1 199 ? 34.199  12.983  29.851 1.000 52.169  0 199 LEU B CA  1 ? 
ATOM   3009 C C   . LEU B 1 199 ? 34.211  12.843  28.326 1.000 51.928  0 199 LEU B C   1 ? 
ATOM   3010 O O   . LEU B 1 199 ? 34.973  12.042  27.807 1.000 56.135  0 199 LEU B O   1 ? 
ATOM   3011 C CB  . LEU B 1 199 ? 34.728  11.717  30.536 1.000 50.157  0 199 LEU B CB  1 ? 
ATOM   3012 N N   . LEU B 1 200 ? 33.426  13.651  27.600 1.000 65.185  0 200 LEU B N   1 ? 
ATOM   3013 C CA  . LEU B 1 200 ? 33.679  13.874  26.179 1.000 81.437  0 200 LEU B CA  1 ? 
ATOM   3014 C C   . LEU B 1 200 ? 34.974  14.664  26.000 1.000 88.949  0 200 LEU B C   1 ? 
ATOM   3015 O O   . LEU B 1 200 ? 35.887  14.202  25.321 1.000 102.001 0 200 LEU B O   1 ? 
ATOM   3016 C CB  . LEU B 1 200 ? 32.519  14.634  25.530 1.000 92.594  0 200 LEU B CB  1 ? 
ATOM   3017 C CG  . LEU B 1 200 ? 32.595  14.811  24.008 1.000 108.045 0 200 LEU B CG  1 ? 
ATOM   3018 C CD1 . LEU B 1 200 ? 33.348  16.082  23.586 1.000 100.653 0 200 LEU B CD1 1 ? 
ATOM   3019 C CD2 . LEU B 1 200 ? 33.194  13.573  23.339 1.000 108.563 0 200 LEU B CD2 1 ? 
ATOM   3020 N N   . GLU B 1 201 ? 35.043  15.852  26.617 1.000 92.156  0 201 GLU B N   1 ? 
ATOM   3021 C CA  . GLU B 1 201 ? 36.210  16.716  26.511 1.000 86.943  0 201 GLU B CA  1 ? 
ATOM   3022 C C   . GLU B 1 201 ? 37.357  16.093  27.312 1.000 81.010  0 201 GLU B C   1 ? 
ATOM   3023 O O   . GLU B 1 201 ? 38.323  15.629  26.698 1.000 107.582 0 201 GLU B O   1 ? 
ATOM   3024 C CB  . GLU B 1 201 ? 35.878  18.159  26.912 1.000 78.777  0 201 GLU B CB  1 ? 
ATOM   3025 N N   . LEU B 1 202 ? 37.286  16.068  28.657 1.000 62.414  0 202 LEU B N   1 ? 
ATOM   3026 C CA  . LEU B 1 202 ? 38.394  15.469  29.399 1.000 59.733  0 202 LEU B CA  1 ? 
ATOM   3027 C C   . LEU B 1 202 ? 37.882  14.504  30.443 1.000 30.742  0 202 LEU B C   1 ? 
ATOM   3028 O O   . LEU B 1 202 ? 37.828  13.317  30.210 1.000 47.578  0 202 LEU B O   1 ? 
ATOM   3029 C CB  . LEU B 1 202 ? 39.355  16.517  29.991 1.000 70.016  0 202 LEU B CB  1 ? 
ATOM   3030 C CG  . LEU B 1 202 ? 40.739  15.991  30.402 1.000 77.453  0 202 LEU B CG  1 ? 
ATOM   3031 C CD1 . LEU B 1 202 ? 41.387  15.212  29.257 1.000 82.527  0 202 LEU B CD1 1 ? 
ATOM   3032 C CD2 . LEU B 1 202 ? 41.648  17.132  30.850 1.000 83.297  0 202 LEU B CD2 1 ? 
ATOM   3033 N N   . VAL B 1 203 ? 37.583  14.976  31.582 1.000 20.046  0 203 VAL B N   1 ? 
ATOM   3034 C CA  . VAL B 1 203 ? 37.283  14.075  32.654 1.000 32.247  0 203 VAL B CA  1 ? 
ATOM   3035 C C   . VAL B 1 203 ? 35.758  13.949  32.821 1.000 36.992  0 203 VAL B C   1 ? 
ATOM   3036 O O   . VAL B 1 203 ? 35.302  13.038  33.578 1.000 35.875  0 203 VAL B O   1 ? 
ATOM   3037 C CB  . VAL B 1 203 ? 38.002  14.549  33.935 1.000 44.415  0 203 VAL B CB  1 ? 
HETATM 3038 C C1  . CIT C 2 .   ? 29.505  15.162  22.696 1.000 52.239  0 301 CIT B C1  1 ? 
HETATM 3039 O O1  . CIT C 2 .   ? 29.679  16.314  23.163 1.000 60.500  0 301 CIT B O1  1 ? 
HETATM 3040 O O2  . CIT C 2 .   ? 30.213  14.666  21.763 1.000 53.413  0 301 CIT B O2  1 ? 
HETATM 3041 C C2  . CIT C 2 .   ? 28.350  14.339  23.274 1.000 39.398  0 301 CIT B C2  1 ? 
HETATM 3042 C C3  . CIT C 2 .   ? 28.590  13.639  24.594 1.000 22.991  0 301 CIT B C3  1 ? 
HETATM 3043 O O7  . CIT C 2 .   ? 29.177  14.543  25.460 1.000 43.348  0 301 CIT B O7  1 ? 
HETATM 3044 C C4  . CIT C 2 .   ? 29.431  12.411  24.465 1.000 28.498  0 301 CIT B C4  1 ? 
HETATM 3045 C C5  . CIT C 2 .   ? 29.925  11.711  25.721 1.000 38.562  0 301 CIT B C5  1 ? 
HETATM 3046 O O3  . CIT C 2 .   ? 30.938  12.160  26.281 1.000 51.505  0 301 CIT B O3  1 ? 
HETATM 3047 O O4  . CIT C 2 .   ? 29.424  10.613  26.042 1.000 43.840  0 301 CIT B O4  1 ? 
HETATM 3048 C C6  . CIT C 2 .   ? 27.289  13.236  25.154 1.000 31.929  0 301 CIT B C6  1 ? 
HETATM 3049 O O5  . CIT C 2 .   ? 26.416  14.097  25.137 1.000 51.629  0 301 CIT B O5  1 ? 
HETATM 3050 O O6  . CIT C 2 .   ? 27.241  12.103  25.579 1.000 50.567  0 301 CIT B O6  1 ? 
HETATM 3051 O O   . HOH D 3 .   ? -18.337 -12.581 9.512  1.000 31.728  0 301 HOH A O   1 ? 
HETATM 3052 O O   . HOH D 3 .   ? 1.954   12.444  16.190 1.000 33.980  0 302 HOH A O   1 ? 
HETATM 3053 O O   . HOH D 3 .   ? -2.416  2.986   5.420  1.000 31.267  0 303 HOH A O   1 ? 
HETATM 3054 O O   . HOH D 3 .   ? -11.112 11.325  15.701 1.000 39.632  0 304 HOH A O   1 ? 
HETATM 3055 O O   . HOH D 3 .   ? 7.018   -11.804 13.643 1.000 47.318  0 305 HOH A O   1 ? 
HETATM 3056 O O   . HOH D 3 .   ? 15.667  -1.225  2.648  1.000 31.451  0 306 HOH A O   1 ? 
HETATM 3057 O O   . HOH D 3 .   ? 19.627  -4.263  0.600  1.000 43.940  0 307 HOH A O   1 ? 
HETATM 3058 O O   . HOH D 3 .   ? -0.616  -3.336  3.371  1.000 27.796  0 308 HOH A O   1 ? 
HETATM 3059 O O   . HOH D 3 .   ? 34.154  -4.429  3.127  1.000 35.833  0 309 HOH A O   1 ? 
HETATM 3060 O O   . HOH D 3 .   ? 29.726  -4.954  15.075 1.000 38.660  0 310 HOH A O   1 ? 
HETATM 3061 O O   . HOH D 3 .   ? -2.952  11.263  6.163  1.000 34.980  0 311 HOH A O   1 ? 
HETATM 3062 O O   . HOH D 3 .   ? -2.080  5.905   -2.037 1.000 28.604  0 312 HOH A O   1 ? 
HETATM 3063 O O   . HOH D 3 .   ? 9.316   7.175   18.500 1.000 36.677  0 313 HOH A O   1 ? 
HETATM 3064 O O   . HOH D 3 .   ? 22.337  13.800  20.439 1.000 42.809  0 314 HOH A O   1 ? 
HETATM 3065 O O   . HOH D 3 .   ? 15.060  -9.371  7.914  1.000 34.527  0 315 HOH A O   1 ? 
HETATM 3066 O O   . HOH D 3 .   ? 5.489   -6.935  2.940  1.000 24.621  0 316 HOH A O   1 ? 
HETATM 3067 O O   . HOH D 3 .   ? 10.613  2.771   17.262 1.000 28.806  0 317 HOH A O   1 ? 
HETATM 3068 O O   . HOH D 3 .   ? -3.653  -2.635  1.884  1.000 29.280  0 318 HOH A O   1 ? 
HETATM 3069 O O   . HOH D 3 .   ? 24.834  14.004  4.041  1.000 58.400  0 319 HOH A O   1 ? 
HETATM 3070 O O   . HOH D 3 .   ? -1.656  5.231   7.215  1.000 31.302  0 320 HOH A O   1 ? 
HETATM 3071 O O   . HOH D 3 .   ? 0.234   -12.740 14.241 1.000 39.187  0 321 HOH A O   1 ? 
HETATM 3072 O O   . HOH D 3 .   ? 22.957  6.424   1.570  1.000 48.702  0 322 HOH A O   1 ? 
HETATM 3073 O O   . HOH D 3 .   ? -3.805  15.337  11.541 1.000 36.945  0 323 HOH A O   1 ? 
HETATM 3074 O O   . HOH D 3 .   ? 33.735  3.376   10.296 1.000 29.002  0 324 HOH A O   1 ? 
HETATM 3075 O O   . HOH D 3 .   ? -20.190 3.716   10.620 1.000 33.187  0 325 HOH A O   1 ? 
HETATM 3076 O O   . HOH D 3 .   ? -10.940 10.489  18.628 1.000 32.855  0 326 HOH A O   1 ? 
HETATM 3077 O O   . HOH D 3 .   ? -0.155  -14.885 3.123  1.000 39.943  0 327 HOH A O   1 ? 
HETATM 3078 O O   . HOH D 3 .   ? 7.989   -7.543  3.800  1.000 51.789  0 328 HOH A O   1 ? 
HETATM 3079 O O   . HOH D 3 .   ? -1.947  13.415  4.041  1.000 39.736  0 329 HOH A O   1 ? 
HETATM 3080 O O   . HOH D 3 .   ? 4.246   -7.184  19.556 1.000 44.180  0 330 HOH A O   1 ? 
HETATM 3081 O O   . HOH D 3 .   ? -3.279  6.633   12.857 1.000 24.876  0 331 HOH A O   1 ? 
HETATM 3082 O O   . HOH D 3 .   ? 27.466  12.408  2.890  1.000 42.970  0 332 HOH A O   1 ? 
HETATM 3083 O O   . HOH D 3 .   ? 14.554  -8.641  3.218  1.000 42.462  0 333 HOH A O   1 ? 
HETATM 3084 O O   . HOH D 3 .   ? -12.969 10.953  22.711 1.000 33.974  0 334 HOH A O   1 ? 
HETATM 3085 O O   . HOH D 3 .   ? -19.305 -2.042  10.092 1.000 50.864  0 335 HOH A O   1 ? 
HETATM 3086 O O   . HOH D 3 .   ? -3.144  -14.893 14.442 1.000 37.205  0 336 HOH A O   1 ? 
HETATM 3087 O O   . HOH D 3 .   ? 3.623   -7.884  3.836  1.000 34.507  0 337 HOH A O   1 ? 
HETATM 3088 O O   . HOH D 3 .   ? 19.434  -7.311  -0.027 1.000 43.908  0 338 HOH A O   1 ? 
HETATM 3089 O O   . HOH D 3 .   ? -12.949 -16.506 9.697  1.000 37.471  0 339 HOH A O   1 ? 
HETATM 3090 O O   . HOH D 3 .   ? -9.338  17.315  12.611 1.000 42.925  0 340 HOH A O   1 ? 
HETATM 3091 O O   . HOH D 3 .   ? 15.446  12.302  -1.940 1.000 55.980  0 341 HOH A O   1 ? 
HETATM 3092 O O   . HOH D 3 .   ? 13.063  11.615  22.521 1.000 24.856  0 342 HOH A O   1 ? 
HETATM 3093 O O   . HOH D 3 .   ? -5.541  -19.728 2.813  1.000 40.862  0 343 HOH A O   1 ? 
HETATM 3094 O O   . HOH E 3 .   ? 10.722  -11.419 35.027 1.000 39.693  0 401 HOH B O   1 ? 
HETATM 3095 O O   . HOH E 3 .   ? 20.090  2.956   43.653 1.000 28.309  0 402 HOH B O   1 ? 
HETATM 3096 O O   . HOH E 3 .   ? 2.041   -1.384  46.232 1.000 18.145  0 403 HOH B O   1 ? 
HETATM 3097 O O   . HOH E 3 .   ? 18.109  7.920   48.312 1.000 31.538  0 404 HOH B O   1 ? 
HETATM 3098 O O   . HOH E 3 .   ? -9.685  12.909  44.314 1.000 28.593  0 405 HOH B O   1 ? 
HETATM 3099 O O   . HOH E 3 .   ? 34.281  14.890  38.341 1.000 41.644  0 406 HOH B O   1 ? 
HETATM 3100 O O   . HOH E 3 .   ? 20.655  11.395  42.696 1.000 37.932  0 407 HOH B O   1 ? 
HETATM 3101 O O   . HOH E 3 .   ? 21.529  -3.093  46.503 1.000 21.841  0 408 HOH B O   1 ? 
HETATM 3102 O O   . HOH E 3 .   ? 6.620   2.782   31.530 1.000 21.673  0 409 HOH B O   1 ? 
HETATM 3103 O O   . HOH E 3 .   ? 5.604   7.245   50.990 1.000 34.176  0 410 HOH B O   1 ? 
HETATM 3104 O O   . HOH E 3 .   ? 4.881   13.133  32.442 1.000 36.588  0 411 HOH B O   1 ? 
HETATM 3105 O O   . HOH E 3 .   ? 19.071  5.141   41.963 1.000 29.807  0 412 HOH B O   1 ? 
HETATM 3106 O O   . HOH E 3 .   ? 25.883  -19.740 28.795 1.000 23.966  0 413 HOH B O   1 ? 
HETATM 3107 O O   . HOH E 3 .   ? 18.029  -15.027 45.635 1.000 32.132  0 414 HOH B O   1 ? 
HETATM 3108 O O   . HOH E 3 .   ? -18.778 3.741   38.830 1.000 30.463  0 415 HOH B O   1 ? 
HETATM 3109 O O   . HOH E 3 .   ? -6.610  6.599   47.353 1.000 39.223  0 416 HOH B O   1 ? 
HETATM 3110 O O   . HOH E 3 .   ? 5.494   -7.745  46.387 1.000 29.138  0 417 HOH B O   1 ? 
HETATM 3111 O O   . HOH E 3 .   ? 19.955  8.254   35.816 1.000 35.567  0 418 HOH B O   1 ? 
HETATM 3112 O O   . HOH E 3 .   ? 31.149  -17.105 46.225 1.000 43.718  0 419 HOH B O   1 ? 
HETATM 3113 O O   . HOH E 3 .   ? 12.799  -7.387  29.044 1.000 30.716  0 420 HOH B O   1 ? 
HETATM 3114 O O   . HOH E 3 .   ? 23.027  20.352  34.748 1.000 29.273  0 421 HOH B O   1 ? 
HETATM 3115 O O   . HOH E 3 .   ? 2.997   -8.579  46.061 1.000 33.337  0 422 HOH B O   1 ? 
HETATM 3116 O O   . HOH E 3 .   ? 21.102  6.099   35.908 1.000 30.672  0 423 HOH B O   1 ? 
HETATM 3117 O O   . HOH E 3 .   ? 17.263  -6.690  45.922 1.000 42.466  0 424 HOH B O   1 ? 
HETATM 3118 O O   . HOH E 3 .   ? 19.668  -14.083 34.414 1.000 23.772  0 425 HOH B O   1 ? 
HETATM 3119 O O   . HOH E 3 .   ? 6.251   9.220   29.330 1.000 41.722  0 426 HOH B O   1 ? 
HETATM 3120 O O   . HOH E 3 .   ? -9.891  12.172  46.928 1.000 33.447  0 427 HOH B O   1 ? 
HETATM 3121 O O   . HOH E 3 .   ? 19.320  -13.122 47.876 1.000 50.580  0 428 HOH B O   1 ? 
HETATM 3122 O O   . HOH E 3 .   ? 16.760  9.082   28.419 1.000 30.773  0 429 HOH B O   1 ? 
HETATM 3123 O O   . HOH E 3 .   ? 2.895   -2.347  48.922 1.000 23.569  0 430 HOH B O   1 ? 
HETATM 3124 O O   . HOH E 3 .   ? 15.743  20.458  40.832 1.000 46.624  0 431 HOH B O   1 ? 
HETATM 3125 O O   . HOH E 3 .   ? 28.263  15.170  45.863 1.000 44.264  0 432 HOH B O   1 ? 
HETATM 3126 O O   . HOH E 3 .   ? 21.106  15.395  47.203 1.000 36.378  0 433 HOH B O   1 ? 
HETATM 3127 O O   . HOH E 3 .   ? 13.647  12.388  29.321 1.000 40.416  0 434 HOH B O   1 ? 
HETATM 3128 O O   . HOH E 3 .   ? 15.306  18.612  49.030 1.000 31.485  0 435 HOH B O   1 ? 
# 
