data_8ZGW
# 
_entry.id   8ZGW 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZGW         pdb_00008zgw 10.2210/pdb8zgw/pdb 
WWPDB D_1300047756 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZGW 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'Drimenyl diphosphate synthase SsDMS_F248A&D303E from Streptomyces showdoensis (Apo)' 8ZG0 unspecified 
PDB 'Drimenyl diphosphate synthase SsDMS_F248Y&D303E from Streptomyces showdoensis (Apo)' 8ZG1 unspecified 
PDB 'Drimenyl diphosphate synthase SsDMS_Y505I&D303A from Streptomyces showdoensis (Apo)' 8ZG5 unspecified 
PDB 
'Drimenyl diphosphate synthase SsDMS_F248A&D303E from Streptomyces showdoensis in complex with farnesyl diphosphate (FPP) and Mg2+' 
8ZGV unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              ldong@cpu.edu.cn 
_pdbx_contact_author.name_first         Liao-Bin 
_pdbx_contact_author.name_last          Dong 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2943-1299 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Pan, X.M.'  1 0000-0002-4265-872X 
'Dong, S.M.' 2 ?                   
'Dong, L.B.' 3 0000-0002-2943-1299 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Catalytic bases in class II terpene cyclases' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Pan, X.M.'  1 0000-0002-4265-872X 
primary 'Dong, S.M.' 2 ?                   
primary 'Dong, L.B.' 3 0000-0002-2943-1299 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Squalene cyclase C-terminal domain-containing protein' 57634.887 1   ? F248Y,D303E ? ? 
2 non-polymer syn 'FARNESYL DIPHOSPHATE'                                  382.326   1   ? ?           ? ? 
3 non-polymer syn 'MAGNESIUM ION'                                         24.305    2   ? ?           ? ? 
4 water       nat water                                                   18.015    211 ? ?           ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;HHHHHHMNASPTPTATTTTEPATAVVRCRTRLARRVVAAVGPDGLLPAPCESRVLESALALALLTEERAEADATARLTAY
LRTTLRTAPPDPFQCAVARAVLGGAGERGERVGDEGDMDAGTALDAGLDGFDHFTAGRKRLMFRTVLAALGATGFPAVPW
EAYDTRPQQSWLHMEMKALKVLAAHGTGHPDVVRDEDWRALLPALEPGPAWECNNLAQLLALLALRHSPRHRPALGDVLK
HVAGRLRPDGGMPYIDGMTVFTTAAAGLALSLLPAPPACVTPMADALALRRNPDGGYGFHSGVAQSDVEDTCYVLEFLRR
AAPDRHRTAVAEAEGYLLALRNPDGGFPTFARGTSSEIAMTAAAASALAHDPDRREEVDEAVRYVVRHQRPDGTFERSWS
RNATNAVFRAVLALTGVAAHGEERRSRARAAERALAHLAATQNGDGGWGHAEAEPSDPISTAYAVIALARGPRARPGGPL
DRALAYLVERQHPDGGYRSRPDQAGPRPLLYDVPALADVFVLLALAHATATPDPEGCSR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;HHHHHHMNASPTPTATTTTEPATAVVRCRTRLARRVVAAVGPDGLLPAPCESRVLESALALALLTEERAEADATARLTAY
LRTTLRTAPPDPFQCAVARAVLGGAGERGERVGDEGDMDAGTALDAGLDGFDHFTAGRKRLMFRTVLAALGATGFPAVPW
EAYDTRPQQSWLHMEMKALKVLAAHGTGHPDVVRDEDWRALLPALEPGPAWECNNLAQLLALLALRHSPRHRPALGDVLK
HVAGRLRPDGGMPYIDGMTVFTTAAAGLALSLLPAPPACVTPMADALALRRNPDGGYGFHSGVAQSDVEDTCYVLEFLRR
AAPDRHRTAVAEAEGYLLALRNPDGGFPTFARGTSSEIAMTAAAASALAHDPDRREEVDEAVRYVVRHQRPDGTFERSWS
RNATNAVFRAVLALTGVAAHGEERRSRARAAERALAHLAATQNGDGGWGHAEAEPSDPISTAYAVIALARGPRARPGGPL
DRALAYLVERQHPDGGYRSRPDQAGPRPLLYDVPALADVFVLLALAHATATPDPEGCSR
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'FARNESYL DIPHOSPHATE' FPP 
3 'MAGNESIUM ION'        MG  
4 water                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   HIS n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   MET n 
1 8   ASN n 
1 9   ALA n 
1 10  SER n 
1 11  PRO n 
1 12  THR n 
1 13  PRO n 
1 14  THR n 
1 15  ALA n 
1 16  THR n 
1 17  THR n 
1 18  THR n 
1 19  THR n 
1 20  GLU n 
1 21  PRO n 
1 22  ALA n 
1 23  THR n 
1 24  ALA n 
1 25  VAL n 
1 26  VAL n 
1 27  ARG n 
1 28  CYS n 
1 29  ARG n 
1 30  THR n 
1 31  ARG n 
1 32  LEU n 
1 33  ALA n 
1 34  ARG n 
1 35  ARG n 
1 36  VAL n 
1 37  VAL n 
1 38  ALA n 
1 39  ALA n 
1 40  VAL n 
1 41  GLY n 
1 42  PRO n 
1 43  ASP n 
1 44  GLY n 
1 45  LEU n 
1 46  LEU n 
1 47  PRO n 
1 48  ALA n 
1 49  PRO n 
1 50  CYS n 
1 51  GLU n 
1 52  SER n 
1 53  ARG n 
1 54  VAL n 
1 55  LEU n 
1 56  GLU n 
1 57  SER n 
1 58  ALA n 
1 59  LEU n 
1 60  ALA n 
1 61  LEU n 
1 62  ALA n 
1 63  LEU n 
1 64  LEU n 
1 65  THR n 
1 66  GLU n 
1 67  GLU n 
1 68  ARG n 
1 69  ALA n 
1 70  GLU n 
1 71  ALA n 
1 72  ASP n 
1 73  ALA n 
1 74  THR n 
1 75  ALA n 
1 76  ARG n 
1 77  LEU n 
1 78  THR n 
1 79  ALA n 
1 80  TYR n 
1 81  LEU n 
1 82  ARG n 
1 83  THR n 
1 84  THR n 
1 85  LEU n 
1 86  ARG n 
1 87  THR n 
1 88  ALA n 
1 89  PRO n 
1 90  PRO n 
1 91  ASP n 
1 92  PRO n 
1 93  PHE n 
1 94  GLN n 
1 95  CYS n 
1 96  ALA n 
1 97  VAL n 
1 98  ALA n 
1 99  ARG n 
1 100 ALA n 
1 101 VAL n 
1 102 LEU n 
1 103 GLY n 
1 104 GLY n 
1 105 ALA n 
1 106 GLY n 
1 107 GLU n 
1 108 ARG n 
1 109 GLY n 
1 110 GLU n 
1 111 ARG n 
1 112 VAL n 
1 113 GLY n 
1 114 ASP n 
1 115 GLU n 
1 116 GLY n 
1 117 ASP n 
1 118 MET n 
1 119 ASP n 
1 120 ALA n 
1 121 GLY n 
1 122 THR n 
1 123 ALA n 
1 124 LEU n 
1 125 ASP n 
1 126 ALA n 
1 127 GLY n 
1 128 LEU n 
1 129 ASP n 
1 130 GLY n 
1 131 PHE n 
1 132 ASP n 
1 133 HIS n 
1 134 PHE n 
1 135 THR n 
1 136 ALA n 
1 137 GLY n 
1 138 ARG n 
1 139 LYS n 
1 140 ARG n 
1 141 LEU n 
1 142 MET n 
1 143 PHE n 
1 144 ARG n 
1 145 THR n 
1 146 VAL n 
1 147 LEU n 
1 148 ALA n 
1 149 ALA n 
1 150 LEU n 
1 151 GLY n 
1 152 ALA n 
1 153 THR n 
1 154 GLY n 
1 155 PHE n 
1 156 PRO n 
1 157 ALA n 
1 158 VAL n 
1 159 PRO n 
1 160 TRP n 
1 161 GLU n 
1 162 ALA n 
1 163 TYR n 
1 164 ASP n 
1 165 THR n 
1 166 ARG n 
1 167 PRO n 
1 168 GLN n 
1 169 GLN n 
1 170 SER n 
1 171 TRP n 
1 172 LEU n 
1 173 HIS n 
1 174 MET n 
1 175 GLU n 
1 176 MET n 
1 177 LYS n 
1 178 ALA n 
1 179 LEU n 
1 180 LYS n 
1 181 VAL n 
1 182 LEU n 
1 183 ALA n 
1 184 ALA n 
1 185 HIS n 
1 186 GLY n 
1 187 THR n 
1 188 GLY n 
1 189 HIS n 
1 190 PRO n 
1 191 ASP n 
1 192 VAL n 
1 193 VAL n 
1 194 ARG n 
1 195 ASP n 
1 196 GLU n 
1 197 ASP n 
1 198 TRP n 
1 199 ARG n 
1 200 ALA n 
1 201 LEU n 
1 202 LEU n 
1 203 PRO n 
1 204 ALA n 
1 205 LEU n 
1 206 GLU n 
1 207 PRO n 
1 208 GLY n 
1 209 PRO n 
1 210 ALA n 
1 211 TRP n 
1 212 GLU n 
1 213 CYS n 
1 214 ASN n 
1 215 ASN n 
1 216 LEU n 
1 217 ALA n 
1 218 GLN n 
1 219 LEU n 
1 220 LEU n 
1 221 ALA n 
1 222 LEU n 
1 223 LEU n 
1 224 ALA n 
1 225 LEU n 
1 226 ARG n 
1 227 HIS n 
1 228 SER n 
1 229 PRO n 
1 230 ARG n 
1 231 HIS n 
1 232 ARG n 
1 233 PRO n 
1 234 ALA n 
1 235 LEU n 
1 236 GLY n 
1 237 ASP n 
1 238 VAL n 
1 239 LEU n 
1 240 LYS n 
1 241 HIS n 
1 242 VAL n 
1 243 ALA n 
1 244 GLY n 
1 245 ARG n 
1 246 LEU n 
1 247 ARG n 
1 248 PRO n 
1 249 ASP n 
1 250 GLY n 
1 251 GLY n 
1 252 MET n 
1 253 PRO n 
1 254 TYR n 
1 255 ILE n 
1 256 ASP n 
1 257 GLY n 
1 258 MET n 
1 259 THR n 
1 260 VAL n 
1 261 PHE n 
1 262 THR n 
1 263 THR n 
1 264 ALA n 
1 265 ALA n 
1 266 ALA n 
1 267 GLY n 
1 268 LEU n 
1 269 ALA n 
1 270 LEU n 
1 271 SER n 
1 272 LEU n 
1 273 LEU n 
1 274 PRO n 
1 275 ALA n 
1 276 PRO n 
1 277 PRO n 
1 278 ALA n 
1 279 CYS n 
1 280 VAL n 
1 281 THR n 
1 282 PRO n 
1 283 MET n 
1 284 ALA n 
1 285 ASP n 
1 286 ALA n 
1 287 LEU n 
1 288 ALA n 
1 289 LEU n 
1 290 ARG n 
1 291 ARG n 
1 292 ASN n 
1 293 PRO n 
1 294 ASP n 
1 295 GLY n 
1 296 GLY n 
1 297 TYR n 
1 298 GLY n 
1 299 PHE n 
1 300 HIS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 ALA n 
1 305 GLN n 
1 306 SER n 
1 307 ASP n 
1 308 VAL n 
1 309 GLU n 
1 310 ASP n 
1 311 THR n 
1 312 CYS n 
1 313 TYR n 
1 314 VAL n 
1 315 LEU n 
1 316 GLU n 
1 317 PHE n 
1 318 LEU n 
1 319 ARG n 
1 320 ARG n 
1 321 ALA n 
1 322 ALA n 
1 323 PRO n 
1 324 ASP n 
1 325 ARG n 
1 326 HIS n 
1 327 ARG n 
1 328 THR n 
1 329 ALA n 
1 330 VAL n 
1 331 ALA n 
1 332 GLU n 
1 333 ALA n 
1 334 GLU n 
1 335 GLY n 
1 336 TYR n 
1 337 LEU n 
1 338 LEU n 
1 339 ALA n 
1 340 LEU n 
1 341 ARG n 
1 342 ASN n 
1 343 PRO n 
1 344 ASP n 
1 345 GLY n 
1 346 GLY n 
1 347 PHE n 
1 348 PRO n 
1 349 THR n 
1 350 PHE n 
1 351 ALA n 
1 352 ARG n 
1 353 GLY n 
1 354 THR n 
1 355 SER n 
1 356 SER n 
1 357 GLU n 
1 358 ILE n 
1 359 ALA n 
1 360 MET n 
1 361 THR n 
1 362 ALA n 
1 363 ALA n 
1 364 ALA n 
1 365 ALA n 
1 366 SER n 
1 367 ALA n 
1 368 LEU n 
1 369 ALA n 
1 370 HIS n 
1 371 ASP n 
1 372 PRO n 
1 373 ASP n 
1 374 ARG n 
1 375 ARG n 
1 376 GLU n 
1 377 GLU n 
1 378 VAL n 
1 379 ASP n 
1 380 GLU n 
1 381 ALA n 
1 382 VAL n 
1 383 ARG n 
1 384 TYR n 
1 385 VAL n 
1 386 VAL n 
1 387 ARG n 
1 388 HIS n 
1 389 GLN n 
1 390 ARG n 
1 391 PRO n 
1 392 ASP n 
1 393 GLY n 
1 394 THR n 
1 395 PHE n 
1 396 GLU n 
1 397 ARG n 
1 398 SER n 
1 399 TRP n 
1 400 SER n 
1 401 ARG n 
1 402 ASN n 
1 403 ALA n 
1 404 THR n 
1 405 ASN n 
1 406 ALA n 
1 407 VAL n 
1 408 PHE n 
1 409 ARG n 
1 410 ALA n 
1 411 VAL n 
1 412 LEU n 
1 413 ALA n 
1 414 LEU n 
1 415 THR n 
1 416 GLY n 
1 417 VAL n 
1 418 ALA n 
1 419 ALA n 
1 420 HIS n 
1 421 GLY n 
1 422 GLU n 
1 423 GLU n 
1 424 ARG n 
1 425 ARG n 
1 426 SER n 
1 427 ARG n 
1 428 ALA n 
1 429 ARG n 
1 430 ALA n 
1 431 ALA n 
1 432 GLU n 
1 433 ARG n 
1 434 ALA n 
1 435 LEU n 
1 436 ALA n 
1 437 HIS n 
1 438 LEU n 
1 439 ALA n 
1 440 ALA n 
1 441 THR n 
1 442 GLN n 
1 443 ASN n 
1 444 GLY n 
1 445 ASP n 
1 446 GLY n 
1 447 GLY n 
1 448 TRP n 
1 449 GLY n 
1 450 HIS n 
1 451 ALA n 
1 452 GLU n 
1 453 ALA n 
1 454 GLU n 
1 455 PRO n 
1 456 SER n 
1 457 ASP n 
1 458 PRO n 
1 459 ILE n 
1 460 SER n 
1 461 THR n 
1 462 ALA n 
1 463 TYR n 
1 464 ALA n 
1 465 VAL n 
1 466 ILE n 
1 467 ALA n 
1 468 LEU n 
1 469 ALA n 
1 470 ARG n 
1 471 GLY n 
1 472 PRO n 
1 473 ARG n 
1 474 ALA n 
1 475 ARG n 
1 476 PRO n 
1 477 GLY n 
1 478 GLY n 
1 479 PRO n 
1 480 LEU n 
1 481 ASP n 
1 482 ARG n 
1 483 ALA n 
1 484 LEU n 
1 485 ALA n 
1 486 TYR n 
1 487 LEU n 
1 488 VAL n 
1 489 GLU n 
1 490 ARG n 
1 491 GLN n 
1 492 HIS n 
1 493 PRO n 
1 494 ASP n 
1 495 GLY n 
1 496 GLY n 
1 497 TYR n 
1 498 ARG n 
1 499 SER n 
1 500 ARG n 
1 501 PRO n 
1 502 ASP n 
1 503 GLN n 
1 504 ALA n 
1 505 GLY n 
1 506 PRO n 
1 507 ARG n 
1 508 PRO n 
1 509 LEU n 
1 510 LEU n 
1 511 TYR n 
1 512 ASP n 
1 513 VAL n 
1 514 PRO n 
1 515 ALA n 
1 516 LEU n 
1 517 ALA n 
1 518 ASP n 
1 519 VAL n 
1 520 PHE n 
1 521 VAL n 
1 522 LEU n 
1 523 LEU n 
1 524 ALA n 
1 525 LEU n 
1 526 ALA n 
1 527 HIS n 
1 528 ALA n 
1 529 THR n 
1 530 ALA n 
1 531 THR n 
1 532 PRO n 
1 533 ASP n 
1 534 PRO n 
1 535 GLU n 
1 536 GLY n 
1 537 CYS n 
1 538 SER n 
1 539 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   539 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 VO63_21045 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Streptomyces showdoensis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     68268 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE               ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE             ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'        ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE               ? 'C3 H7 N O2 S'   121.158 
FPP non-polymer         . 'FARNESYL DIPHOSPHATE' ? 'C15 H28 O7 P2'  382.326 
GLN 'L-peptide linking' y GLUTAMINE              ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'        ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE              ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                  ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE             ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                 ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE             ? 'C5 H11 N O2 S'  149.211 
MG  non-polymer         . 'MAGNESIUM ION'        ? 'Mg 2'           24.305  
PHE 'L-peptide linking' y PHENYLALANINE          ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                 ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE              ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN             ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE               ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                 ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   HIS 1   -5  ?   ?   ?   A . n 
A 1 2   HIS 2   -4  ?   ?   ?   A . n 
A 1 3   HIS 3   -3  ?   ?   ?   A . n 
A 1 4   HIS 4   -2  ?   ?   ?   A . n 
A 1 5   HIS 5   -1  ?   ?   ?   A . n 
A 1 6   HIS 6   0   ?   ?   ?   A . n 
A 1 7   MET 7   1   ?   ?   ?   A . n 
A 1 8   ASN 8   2   ?   ?   ?   A . n 
A 1 9   ALA 9   3   ?   ?   ?   A . n 
A 1 10  SER 10  4   ?   ?   ?   A . n 
A 1 11  PRO 11  5   ?   ?   ?   A . n 
A 1 12  THR 12  6   ?   ?   ?   A . n 
A 1 13  PRO 13  7   ?   ?   ?   A . n 
A 1 14  THR 14  8   ?   ?   ?   A . n 
A 1 15  ALA 15  9   ?   ?   ?   A . n 
A 1 16  THR 16  10  ?   ?   ?   A . n 
A 1 17  THR 17  11  ?   ?   ?   A . n 
A 1 18  THR 18  12  ?   ?   ?   A . n 
A 1 19  THR 19  13  ?   ?   ?   A . n 
A 1 20  GLU 20  14  ?   ?   ?   A . n 
A 1 21  PRO 21  15  ?   ?   ?   A . n 
A 1 22  ALA 22  16  16  ALA ALA A . n 
A 1 23  THR 23  17  17  THR THR A . n 
A 1 24  ALA 24  18  18  ALA ALA A . n 
A 1 25  VAL 25  19  19  VAL VAL A . n 
A 1 26  VAL 26  20  20  VAL VAL A . n 
A 1 27  ARG 27  21  21  ARG ARG A . n 
A 1 28  CYS 28  22  22  CYS CYS A . n 
A 1 29  ARG 29  23  23  ARG ARG A . n 
A 1 30  THR 30  24  24  THR THR A . n 
A 1 31  ARG 31  25  25  ARG ARG A . n 
A 1 32  LEU 32  26  26  LEU LEU A . n 
A 1 33  ALA 33  27  27  ALA ALA A . n 
A 1 34  ARG 34  28  28  ARG ARG A . n 
A 1 35  ARG 35  29  29  ARG ARG A . n 
A 1 36  VAL 36  30  30  VAL VAL A . n 
A 1 37  VAL 37  31  31  VAL VAL A . n 
A 1 38  ALA 38  32  32  ALA ALA A . n 
A 1 39  ALA 39  33  33  ALA ALA A . n 
A 1 40  VAL 40  34  34  VAL VAL A . n 
A 1 41  GLY 41  35  35  GLY GLY A . n 
A 1 42  PRO 42  36  36  PRO PRO A . n 
A 1 43  ASP 43  37  37  ASP ASP A . n 
A 1 44  GLY 44  38  38  GLY GLY A . n 
A 1 45  LEU 45  39  39  LEU LEU A . n 
A 1 46  LEU 46  40  40  LEU LEU A . n 
A 1 47  PRO 47  41  41  PRO PRO A . n 
A 1 48  ALA 48  42  42  ALA ALA A . n 
A 1 49  PRO 49  43  43  PRO PRO A . n 
A 1 50  CYS 50  44  44  CYS CYS A . n 
A 1 51  GLU 51  45  45  GLU GLU A . n 
A 1 52  SER 52  46  46  SER SER A . n 
A 1 53  ARG 53  47  47  ARG ARG A . n 
A 1 54  VAL 54  48  48  VAL VAL A . n 
A 1 55  LEU 55  49  49  LEU LEU A . n 
A 1 56  GLU 56  50  50  GLU GLU A . n 
A 1 57  SER 57  51  51  SER SER A . n 
A 1 58  ALA 58  52  52  ALA ALA A . n 
A 1 59  LEU 59  53  53  LEU LEU A . n 
A 1 60  ALA 60  54  54  ALA ALA A . n 
A 1 61  LEU 61  55  55  LEU LEU A . n 
A 1 62  ALA 62  56  56  ALA ALA A . n 
A 1 63  LEU 63  57  57  LEU LEU A . n 
A 1 64  LEU 64  58  58  LEU LEU A . n 
A 1 65  THR 65  59  59  THR THR A . n 
A 1 66  GLU 66  60  60  GLU GLU A . n 
A 1 67  GLU 67  61  61  GLU GLU A . n 
A 1 68  ARG 68  62  62  ARG ARG A . n 
A 1 69  ALA 69  63  63  ALA ALA A . n 
A 1 70  GLU 70  64  64  GLU GLU A . n 
A 1 71  ALA 71  65  65  ALA ALA A . n 
A 1 72  ASP 72  66  66  ASP ASP A . n 
A 1 73  ALA 73  67  67  ALA ALA A . n 
A 1 74  THR 74  68  68  THR THR A . n 
A 1 75  ALA 75  69  69  ALA ALA A . n 
A 1 76  ARG 76  70  70  ARG ARG A . n 
A 1 77  LEU 77  71  71  LEU LEU A . n 
A 1 78  THR 78  72  72  THR THR A . n 
A 1 79  ALA 79  73  73  ALA ALA A . n 
A 1 80  TYR 80  74  74  TYR TYR A . n 
A 1 81  LEU 81  75  75  LEU LEU A . n 
A 1 82  ARG 82  76  76  ARG ARG A . n 
A 1 83  THR 83  77  77  THR THR A . n 
A 1 84  THR 84  78  78  THR THR A . n 
A 1 85  LEU 85  79  79  LEU LEU A . n 
A 1 86  ARG 86  80  80  ARG ARG A . n 
A 1 87  THR 87  81  81  THR THR A . n 
A 1 88  ALA 88  82  82  ALA ALA A . n 
A 1 89  PRO 89  83  83  PRO PRO A . n 
A 1 90  PRO 90  84  84  PRO PRO A . n 
A 1 91  ASP 91  85  85  ASP ASP A . n 
A 1 92  PRO 92  86  86  PRO PRO A . n 
A 1 93  PHE 93  87  87  PHE PHE A . n 
A 1 94  GLN 94  88  88  GLN GLN A . n 
A 1 95  CYS 95  89  89  CYS CYS A . n 
A 1 96  ALA 96  90  90  ALA ALA A . n 
A 1 97  VAL 97  91  91  VAL VAL A . n 
A 1 98  ALA 98  92  92  ALA ALA A . n 
A 1 99  ARG 99  93  93  ARG ARG A . n 
A 1 100 ALA 100 94  94  ALA ALA A . n 
A 1 101 VAL 101 95  95  VAL VAL A . n 
A 1 102 LEU 102 96  96  LEU LEU A . n 
A 1 103 GLY 103 97  97  GLY GLY A . n 
A 1 104 GLY 104 98  ?   ?   ?   A . n 
A 1 105 ALA 105 99  ?   ?   ?   A . n 
A 1 106 GLY 106 100 ?   ?   ?   A . n 
A 1 107 GLU 107 101 ?   ?   ?   A . n 
A 1 108 ARG 108 102 ?   ?   ?   A . n 
A 1 109 GLY 109 103 ?   ?   ?   A . n 
A 1 110 GLU 110 104 ?   ?   ?   A . n 
A 1 111 ARG 111 105 ?   ?   ?   A . n 
A 1 112 VAL 112 106 ?   ?   ?   A . n 
A 1 113 GLY 113 107 ?   ?   ?   A . n 
A 1 114 ASP 114 108 ?   ?   ?   A . n 
A 1 115 GLU 115 109 ?   ?   ?   A . n 
A 1 116 GLY 116 110 ?   ?   ?   A . n 
A 1 117 ASP 117 111 ?   ?   ?   A . n 
A 1 118 MET 118 112 ?   ?   ?   A . n 
A 1 119 ASP 119 113 ?   ?   ?   A . n 
A 1 120 ALA 120 114 ?   ?   ?   A . n 
A 1 121 GLY 121 115 ?   ?   ?   A . n 
A 1 122 THR 122 116 ?   ?   ?   A . n 
A 1 123 ALA 123 117 ?   ?   ?   A . n 
A 1 124 LEU 124 118 ?   ?   ?   A . n 
A 1 125 ASP 125 119 ?   ?   ?   A . n 
A 1 126 ALA 126 120 ?   ?   ?   A . n 
A 1 127 GLY 127 121 ?   ?   ?   A . n 
A 1 128 LEU 128 122 ?   ?   ?   A . n 
A 1 129 ASP 129 123 ?   ?   ?   A . n 
A 1 130 GLY 130 124 124 GLY GLY A . n 
A 1 131 PHE 131 125 125 PHE PHE A . n 
A 1 132 ASP 132 126 126 ASP ASP A . n 
A 1 133 HIS 133 127 127 HIS HIS A . n 
A 1 134 PHE 134 128 128 PHE PHE A . n 
A 1 135 THR 135 129 129 THR THR A . n 
A 1 136 ALA 136 130 130 ALA ALA A . n 
A 1 137 GLY 137 131 131 GLY GLY A . n 
A 1 138 ARG 138 132 132 ARG ARG A . n 
A 1 139 LYS 139 133 133 LYS LYS A . n 
A 1 140 ARG 140 134 134 ARG ARG A . n 
A 1 141 LEU 141 135 135 LEU LEU A . n 
A 1 142 MET 142 136 136 MET MET A . n 
A 1 143 PHE 143 137 137 PHE PHE A . n 
A 1 144 ARG 144 138 138 ARG ARG A . n 
A 1 145 THR 145 139 139 THR THR A . n 
A 1 146 VAL 146 140 140 VAL VAL A . n 
A 1 147 LEU 147 141 141 LEU LEU A . n 
A 1 148 ALA 148 142 142 ALA ALA A . n 
A 1 149 ALA 149 143 143 ALA ALA A . n 
A 1 150 LEU 150 144 144 LEU LEU A . n 
A 1 151 GLY 151 145 145 GLY GLY A . n 
A 1 152 ALA 152 146 146 ALA ALA A . n 
A 1 153 THR 153 147 147 THR THR A . n 
A 1 154 GLY 154 148 148 GLY GLY A . n 
A 1 155 PHE 155 149 149 PHE PHE A . n 
A 1 156 PRO 156 150 150 PRO PRO A . n 
A 1 157 ALA 157 151 151 ALA ALA A . n 
A 1 158 VAL 158 152 152 VAL VAL A . n 
A 1 159 PRO 159 153 153 PRO PRO A . n 
A 1 160 TRP 160 154 154 TRP TRP A . n 
A 1 161 GLU 161 155 155 GLU GLU A . n 
A 1 162 ALA 162 156 156 ALA ALA A . n 
A 1 163 TYR 163 157 157 TYR TYR A . n 
A 1 164 ASP 164 158 158 ASP ASP A . n 
A 1 165 THR 165 159 159 THR THR A . n 
A 1 166 ARG 166 160 160 ARG ARG A . n 
A 1 167 PRO 167 161 161 PRO PRO A . n 
A 1 168 GLN 168 162 162 GLN GLN A . n 
A 1 169 GLN 169 163 163 GLN GLN A . n 
A 1 170 SER 170 164 164 SER SER A . n 
A 1 171 TRP 171 165 165 TRP TRP A . n 
A 1 172 LEU 172 166 166 LEU LEU A . n 
A 1 173 HIS 173 167 167 HIS HIS A . n 
A 1 174 MET 174 168 168 MET MET A . n 
A 1 175 GLU 175 169 169 GLU GLU A . n 
A 1 176 MET 176 170 170 MET MET A . n 
A 1 177 LYS 177 171 171 LYS LYS A . n 
A 1 178 ALA 178 172 172 ALA ALA A . n 
A 1 179 LEU 179 173 173 LEU LEU A . n 
A 1 180 LYS 180 174 174 LYS LYS A . n 
A 1 181 VAL 181 175 175 VAL VAL A . n 
A 1 182 LEU 182 176 176 LEU LEU A . n 
A 1 183 ALA 183 177 177 ALA ALA A . n 
A 1 184 ALA 184 178 178 ALA ALA A . n 
A 1 185 HIS 185 179 179 HIS HIS A . n 
A 1 186 GLY 186 180 180 GLY GLY A . n 
A 1 187 THR 187 181 181 THR THR A . n 
A 1 188 GLY 188 182 182 GLY GLY A . n 
A 1 189 HIS 189 183 183 HIS HIS A . n 
A 1 190 PRO 190 184 184 PRO PRO A . n 
A 1 191 ASP 191 185 185 ASP ASP A . n 
A 1 192 VAL 192 186 186 VAL VAL A . n 
A 1 193 VAL 193 187 187 VAL VAL A . n 
A 1 194 ARG 194 188 188 ARG ARG A . n 
A 1 195 ASP 195 189 189 ASP ASP A . n 
A 1 196 GLU 196 190 190 GLU GLU A . n 
A 1 197 ASP 197 191 191 ASP ASP A . n 
A 1 198 TRP 198 192 192 TRP TRP A . n 
A 1 199 ARG 199 193 193 ARG ARG A . n 
A 1 200 ALA 200 194 194 ALA ALA A . n 
A 1 201 LEU 201 195 195 LEU LEU A . n 
A 1 202 LEU 202 196 196 LEU LEU A . n 
A 1 203 PRO 203 197 197 PRO PRO A . n 
A 1 204 ALA 204 198 198 ALA ALA A . n 
A 1 205 LEU 205 199 199 LEU LEU A . n 
A 1 206 GLU 206 200 200 GLU GLU A . n 
A 1 207 PRO 207 201 201 PRO PRO A . n 
A 1 208 GLY 208 202 202 GLY GLY A . n 
A 1 209 PRO 209 203 203 PRO PRO A . n 
A 1 210 ALA 210 204 204 ALA ALA A . n 
A 1 211 TRP 211 205 205 TRP TRP A . n 
A 1 212 GLU 212 206 206 GLU GLU A . n 
A 1 213 CYS 213 207 207 CYS CYS A . n 
A 1 214 ASN 214 208 208 ASN ASN A . n 
A 1 215 ASN 215 209 209 ASN ASN A . n 
A 1 216 LEU 216 210 210 LEU LEU A . n 
A 1 217 ALA 217 211 211 ALA ALA A . n 
A 1 218 GLN 218 212 212 GLN GLN A . n 
A 1 219 LEU 219 213 213 LEU LEU A . n 
A 1 220 LEU 220 214 214 LEU LEU A . n 
A 1 221 ALA 221 215 215 ALA ALA A . n 
A 1 222 LEU 222 216 216 LEU LEU A . n 
A 1 223 LEU 223 217 217 LEU LEU A . n 
A 1 224 ALA 224 218 218 ALA ALA A . n 
A 1 225 LEU 225 219 219 LEU LEU A . n 
A 1 226 ARG 226 220 220 ARG ARG A . n 
A 1 227 HIS 227 221 221 HIS HIS A . n 
A 1 228 SER 228 222 222 SER SER A . n 
A 1 229 PRO 229 223 223 PRO PRO A . n 
A 1 230 ARG 230 224 224 ARG ARG A . n 
A 1 231 HIS 231 225 225 HIS HIS A . n 
A 1 232 ARG 232 226 226 ARG ARG A . n 
A 1 233 PRO 233 227 227 PRO PRO A . n 
A 1 234 ALA 234 228 228 ALA ALA A . n 
A 1 235 LEU 235 229 229 LEU LEU A . n 
A 1 236 GLY 236 230 230 GLY GLY A . n 
A 1 237 ASP 237 231 231 ASP ASP A . n 
A 1 238 VAL 238 232 232 VAL VAL A . n 
A 1 239 LEU 239 233 233 LEU LEU A . n 
A 1 240 LYS 240 234 234 LYS LYS A . n 
A 1 241 HIS 241 235 235 HIS HIS A . n 
A 1 242 VAL 242 236 236 VAL VAL A . n 
A 1 243 ALA 243 237 237 ALA ALA A . n 
A 1 244 GLY 244 238 238 GLY GLY A . n 
A 1 245 ARG 245 239 239 ARG ARG A . n 
A 1 246 LEU 246 240 240 LEU LEU A . n 
A 1 247 ARG 247 241 241 ARG ARG A . n 
A 1 248 PRO 248 242 242 PRO PRO A . n 
A 1 249 ASP 249 243 243 ASP ASP A . n 
A 1 250 GLY 250 244 244 GLY GLY A . n 
A 1 251 GLY 251 245 245 GLY GLY A . n 
A 1 252 MET 252 246 246 MET MET A . n 
A 1 253 PRO 253 247 247 PRO PRO A . n 
A 1 254 TYR 254 248 248 TYR TYR A . n 
A 1 255 ILE 255 249 249 ILE ILE A . n 
A 1 256 ASP 256 250 250 ASP ASP A . n 
A 1 257 GLY 257 251 251 GLY GLY A . n 
A 1 258 MET 258 252 252 MET MET A . n 
A 1 259 THR 259 253 253 THR THR A . n 
A 1 260 VAL 260 254 254 VAL VAL A . n 
A 1 261 PHE 261 255 255 PHE PHE A . n 
A 1 262 THR 262 256 256 THR THR A . n 
A 1 263 THR 263 257 257 THR THR A . n 
A 1 264 ALA 264 258 258 ALA ALA A . n 
A 1 265 ALA 265 259 259 ALA ALA A . n 
A 1 266 ALA 266 260 260 ALA ALA A . n 
A 1 267 GLY 267 261 261 GLY GLY A . n 
A 1 268 LEU 268 262 262 LEU LEU A . n 
A 1 269 ALA 269 263 263 ALA ALA A . n 
A 1 270 LEU 270 264 264 LEU LEU A . n 
A 1 271 SER 271 265 265 SER SER A . n 
A 1 272 LEU 272 266 266 LEU LEU A . n 
A 1 273 LEU 273 267 267 LEU LEU A . n 
A 1 274 PRO 274 268 268 PRO PRO A . n 
A 1 275 ALA 275 269 269 ALA ALA A . n 
A 1 276 PRO 276 270 270 PRO PRO A . n 
A 1 277 PRO 277 271 271 PRO PRO A . n 
A 1 278 ALA 278 272 272 ALA ALA A . n 
A 1 279 CYS 279 273 273 CYS CYS A . n 
A 1 280 VAL 280 274 274 VAL VAL A . n 
A 1 281 THR 281 275 275 THR THR A . n 
A 1 282 PRO 282 276 276 PRO PRO A . n 
A 1 283 MET 283 277 277 MET MET A . n 
A 1 284 ALA 284 278 278 ALA ALA A . n 
A 1 285 ASP 285 279 279 ASP ASP A . n 
A 1 286 ALA 286 280 280 ALA ALA A . n 
A 1 287 LEU 287 281 281 LEU LEU A . n 
A 1 288 ALA 288 282 282 ALA ALA A . n 
A 1 289 LEU 289 283 283 LEU LEU A . n 
A 1 290 ARG 290 284 284 ARG ARG A . n 
A 1 291 ARG 291 285 285 ARG ARG A . n 
A 1 292 ASN 292 286 286 ASN ASN A . n 
A 1 293 PRO 293 287 287 PRO PRO A . n 
A 1 294 ASP 294 288 288 ASP ASP A . n 
A 1 295 GLY 295 289 289 GLY GLY A . n 
A 1 296 GLY 296 290 290 GLY GLY A . n 
A 1 297 TYR 297 291 291 TYR TYR A . n 
A 1 298 GLY 298 292 292 GLY GLY A . n 
A 1 299 PHE 299 293 293 PHE PHE A . n 
A 1 300 HIS 300 294 294 HIS HIS A . n 
A 1 301 SER 301 295 295 SER SER A . n 
A 1 302 GLY 302 296 296 GLY GLY A . n 
A 1 303 VAL 303 297 297 VAL VAL A . n 
A 1 304 ALA 304 298 298 ALA ALA A . n 
A 1 305 GLN 305 299 299 GLN GLN A . n 
A 1 306 SER 306 300 300 SER SER A . n 
A 1 307 ASP 307 301 301 ASP ASP A . n 
A 1 308 VAL 308 302 302 VAL VAL A . n 
A 1 309 GLU 309 303 303 GLU GLU A . n 
A 1 310 ASP 310 304 304 ASP ASP A . n 
A 1 311 THR 311 305 305 THR THR A . n 
A 1 312 CYS 312 306 306 CYS CYS A . n 
A 1 313 TYR 313 307 307 TYR TYR A . n 
A 1 314 VAL 314 308 308 VAL VAL A . n 
A 1 315 LEU 315 309 309 LEU LEU A . n 
A 1 316 GLU 316 310 310 GLU GLU A . n 
A 1 317 PHE 317 311 311 PHE PHE A . n 
A 1 318 LEU 318 312 312 LEU LEU A . n 
A 1 319 ARG 319 313 313 ARG ARG A . n 
A 1 320 ARG 320 314 314 ARG ARG A . n 
A 1 321 ALA 321 315 315 ALA ALA A . n 
A 1 322 ALA 322 316 316 ALA ALA A . n 
A 1 323 PRO 323 317 317 PRO PRO A . n 
A 1 324 ASP 324 318 318 ASP ASP A . n 
A 1 325 ARG 325 319 319 ARG ARG A . n 
A 1 326 HIS 326 320 320 HIS HIS A . n 
A 1 327 ARG 327 321 321 ARG ARG A . n 
A 1 328 THR 328 322 322 THR THR A . n 
A 1 329 ALA 329 323 323 ALA ALA A . n 
A 1 330 VAL 330 324 324 VAL VAL A . n 
A 1 331 ALA 331 325 325 ALA ALA A . n 
A 1 332 GLU 332 326 326 GLU GLU A . n 
A 1 333 ALA 333 327 327 ALA ALA A . n 
A 1 334 GLU 334 328 328 GLU GLU A . n 
A 1 335 GLY 335 329 329 GLY GLY A . n 
A 1 336 TYR 336 330 330 TYR TYR A . n 
A 1 337 LEU 337 331 331 LEU LEU A . n 
A 1 338 LEU 338 332 332 LEU LEU A . n 
A 1 339 ALA 339 333 333 ALA ALA A . n 
A 1 340 LEU 340 334 334 LEU LEU A . n 
A 1 341 ARG 341 335 335 ARG ARG A . n 
A 1 342 ASN 342 336 336 ASN ASN A . n 
A 1 343 PRO 343 337 337 PRO PRO A . n 
A 1 344 ASP 344 338 338 ASP ASP A . n 
A 1 345 GLY 345 339 339 GLY GLY A . n 
A 1 346 GLY 346 340 340 GLY GLY A . n 
A 1 347 PHE 347 341 341 PHE PHE A . n 
A 1 348 PRO 348 342 342 PRO PRO A . n 
A 1 349 THR 349 343 343 THR THR A . n 
A 1 350 PHE 350 344 344 PHE PHE A . n 
A 1 351 ALA 351 345 345 ALA ALA A . n 
A 1 352 ARG 352 346 346 ARG ARG A . n 
A 1 353 GLY 353 347 347 GLY GLY A . n 
A 1 354 THR 354 348 348 THR THR A . n 
A 1 355 SER 355 349 349 SER SER A . n 
A 1 356 SER 356 350 350 SER SER A . n 
A 1 357 GLU 357 351 351 GLU GLU A . n 
A 1 358 ILE 358 352 352 ILE ILE A . n 
A 1 359 ALA 359 353 353 ALA ALA A . n 
A 1 360 MET 360 354 354 MET MET A . n 
A 1 361 THR 361 355 355 THR THR A . n 
A 1 362 ALA 362 356 356 ALA ALA A . n 
A 1 363 ALA 363 357 357 ALA ALA A . n 
A 1 364 ALA 364 358 358 ALA ALA A . n 
A 1 365 ALA 365 359 359 ALA ALA A . n 
A 1 366 SER 366 360 360 SER SER A . n 
A 1 367 ALA 367 361 361 ALA ALA A . n 
A 1 368 LEU 368 362 362 LEU LEU A . n 
A 1 369 ALA 369 363 363 ALA ALA A . n 
A 1 370 HIS 370 364 364 HIS HIS A . n 
A 1 371 ASP 371 365 365 ASP ASP A . n 
A 1 372 PRO 372 366 366 PRO PRO A . n 
A 1 373 ASP 373 367 367 ASP ASP A . n 
A 1 374 ARG 374 368 368 ARG ARG A . n 
A 1 375 ARG 375 369 369 ARG ARG A . n 
A 1 376 GLU 376 370 370 GLU GLU A . n 
A 1 377 GLU 377 371 371 GLU GLU A . n 
A 1 378 VAL 378 372 372 VAL VAL A . n 
A 1 379 ASP 379 373 373 ASP ASP A . n 
A 1 380 GLU 380 374 374 GLU GLU A . n 
A 1 381 ALA 381 375 375 ALA ALA A . n 
A 1 382 VAL 382 376 376 VAL VAL A . n 
A 1 383 ARG 383 377 377 ARG ARG A . n 
A 1 384 TYR 384 378 378 TYR TYR A . n 
A 1 385 VAL 385 379 379 VAL VAL A . n 
A 1 386 VAL 386 380 380 VAL VAL A . n 
A 1 387 ARG 387 381 381 ARG ARG A . n 
A 1 388 HIS 388 382 382 HIS HIS A . n 
A 1 389 GLN 389 383 383 GLN GLN A . n 
A 1 390 ARG 390 384 384 ARG ARG A . n 
A 1 391 PRO 391 385 385 PRO PRO A . n 
A 1 392 ASP 392 386 386 ASP ASP A . n 
A 1 393 GLY 393 387 387 GLY GLY A . n 
A 1 394 THR 394 388 388 THR THR A . n 
A 1 395 PHE 395 389 389 PHE PHE A . n 
A 1 396 GLU 396 390 390 GLU GLU A . n 
A 1 397 ARG 397 391 391 ARG ARG A . n 
A 1 398 SER 398 392 392 SER SER A . n 
A 1 399 TRP 399 393 393 TRP TRP A . n 
A 1 400 SER 400 394 394 SER SER A . n 
A 1 401 ARG 401 395 395 ARG ARG A . n 
A 1 402 ASN 402 396 396 ASN ASN A . n 
A 1 403 ALA 403 397 397 ALA ALA A . n 
A 1 404 THR 404 398 398 THR THR A . n 
A 1 405 ASN 405 399 399 ASN ASN A . n 
A 1 406 ALA 406 400 400 ALA ALA A . n 
A 1 407 VAL 407 401 401 VAL VAL A . n 
A 1 408 PHE 408 402 402 PHE PHE A . n 
A 1 409 ARG 409 403 403 ARG ARG A . n 
A 1 410 ALA 410 404 404 ALA ALA A . n 
A 1 411 VAL 411 405 405 VAL VAL A . n 
A 1 412 LEU 412 406 406 LEU LEU A . n 
A 1 413 ALA 413 407 407 ALA ALA A . n 
A 1 414 LEU 414 408 408 LEU LEU A . n 
A 1 415 THR 415 409 409 THR THR A . n 
A 1 416 GLY 416 410 410 GLY GLY A . n 
A 1 417 VAL 417 411 411 VAL VAL A . n 
A 1 418 ALA 418 412 412 ALA ALA A . n 
A 1 419 ALA 419 413 413 ALA ALA A . n 
A 1 420 HIS 420 414 414 HIS HIS A . n 
A 1 421 GLY 421 415 415 GLY GLY A . n 
A 1 422 GLU 422 416 416 GLU GLU A . n 
A 1 423 GLU 423 417 417 GLU GLU A . n 
A 1 424 ARG 424 418 418 ARG ARG A . n 
A 1 425 ARG 425 419 419 ARG ARG A . n 
A 1 426 SER 426 420 420 SER SER A . n 
A 1 427 ARG 427 421 421 ARG ARG A . n 
A 1 428 ALA 428 422 422 ALA ALA A . n 
A 1 429 ARG 429 423 423 ARG ARG A . n 
A 1 430 ALA 430 424 424 ALA ALA A . n 
A 1 431 ALA 431 425 425 ALA ALA A . n 
A 1 432 GLU 432 426 426 GLU GLU A . n 
A 1 433 ARG 433 427 427 ARG ARG A . n 
A 1 434 ALA 434 428 428 ALA ALA A . n 
A 1 435 LEU 435 429 429 LEU LEU A . n 
A 1 436 ALA 436 430 430 ALA ALA A . n 
A 1 437 HIS 437 431 431 HIS HIS A . n 
A 1 438 LEU 438 432 432 LEU LEU A . n 
A 1 439 ALA 439 433 433 ALA ALA A . n 
A 1 440 ALA 440 434 434 ALA ALA A . n 
A 1 441 THR 441 435 435 THR THR A . n 
A 1 442 GLN 442 436 436 GLN GLN A . n 
A 1 443 ASN 443 437 437 ASN ASN A . n 
A 1 444 GLY 444 438 438 GLY GLY A . n 
A 1 445 ASP 445 439 439 ASP ASP A . n 
A 1 446 GLY 446 440 440 GLY GLY A . n 
A 1 447 GLY 447 441 441 GLY GLY A . n 
A 1 448 TRP 448 442 442 TRP TRP A . n 
A 1 449 GLY 449 443 443 GLY GLY A . n 
A 1 450 HIS 450 444 444 HIS HIS A . n 
A 1 451 ALA 451 445 445 ALA ALA A . n 
A 1 452 GLU 452 446 446 GLU GLU A . n 
A 1 453 ALA 453 447 447 ALA ALA A . n 
A 1 454 GLU 454 448 448 GLU GLU A . n 
A 1 455 PRO 455 449 449 PRO PRO A . n 
A 1 456 SER 456 450 450 SER SER A . n 
A 1 457 ASP 457 451 451 ASP ASP A . n 
A 1 458 PRO 458 452 452 PRO PRO A . n 
A 1 459 ILE 459 453 453 ILE ILE A . n 
A 1 460 SER 460 454 454 SER SER A . n 
A 1 461 THR 461 455 455 THR THR A . n 
A 1 462 ALA 462 456 456 ALA ALA A . n 
A 1 463 TYR 463 457 457 TYR TYR A . n 
A 1 464 ALA 464 458 458 ALA ALA A . n 
A 1 465 VAL 465 459 459 VAL VAL A . n 
A 1 466 ILE 466 460 460 ILE ILE A . n 
A 1 467 ALA 467 461 461 ALA ALA A . n 
A 1 468 LEU 468 462 462 LEU LEU A . n 
A 1 469 ALA 469 463 463 ALA ALA A . n 
A 1 470 ARG 470 464 464 ARG ARG A . n 
A 1 471 GLY 471 465 465 GLY GLY A . n 
A 1 472 PRO 472 466 466 PRO PRO A . n 
A 1 473 ARG 473 467 467 ARG ARG A . n 
A 1 474 ALA 474 468 468 ALA ALA A . n 
A 1 475 ARG 475 469 469 ARG ARG A . n 
A 1 476 PRO 476 470 470 PRO PRO A . n 
A 1 477 GLY 477 471 471 GLY GLY A . n 
A 1 478 GLY 478 472 472 GLY GLY A . n 
A 1 479 PRO 479 473 473 PRO PRO A . n 
A 1 480 LEU 480 474 474 LEU LEU A . n 
A 1 481 ASP 481 475 475 ASP ASP A . n 
A 1 482 ARG 482 476 476 ARG ARG A . n 
A 1 483 ALA 483 477 477 ALA ALA A . n 
A 1 484 LEU 484 478 478 LEU LEU A . n 
A 1 485 ALA 485 479 479 ALA ALA A . n 
A 1 486 TYR 486 480 480 TYR TYR A . n 
A 1 487 LEU 487 481 481 LEU LEU A . n 
A 1 488 VAL 488 482 482 VAL VAL A . n 
A 1 489 GLU 489 483 483 GLU GLU A . n 
A 1 490 ARG 490 484 484 ARG ARG A . n 
A 1 491 GLN 491 485 485 GLN GLN A . n 
A 1 492 HIS 492 486 486 HIS HIS A . n 
A 1 493 PRO 493 487 487 PRO PRO A . n 
A 1 494 ASP 494 488 488 ASP ASP A . n 
A 1 495 GLY 495 489 489 GLY GLY A . n 
A 1 496 GLY 496 490 490 GLY GLY A . n 
A 1 497 TYR 497 491 491 TYR TYR A . n 
A 1 498 ARG 498 492 492 ARG ARG A . n 
A 1 499 SER 499 493 493 SER SER A . n 
A 1 500 ARG 500 494 494 ARG ARG A . n 
A 1 501 PRO 501 495 495 PRO PRO A . n 
A 1 502 ASP 502 496 496 ASP ASP A . n 
A 1 503 GLN 503 497 497 GLN GLN A . n 
A 1 504 ALA 504 498 498 ALA ALA A . n 
A 1 505 GLY 505 499 499 GLY GLY A . n 
A 1 506 PRO 506 500 500 PRO PRO A . n 
A 1 507 ARG 507 501 501 ARG ARG A . n 
A 1 508 PRO 508 502 502 PRO PRO A . n 
A 1 509 LEU 509 503 503 LEU LEU A . n 
A 1 510 LEU 510 504 504 LEU LEU A . n 
A 1 511 TYR 511 505 505 TYR TYR A . n 
A 1 512 ASP 512 506 506 ASP ASP A . n 
A 1 513 VAL 513 507 507 VAL VAL A . n 
A 1 514 PRO 514 508 508 PRO PRO A . n 
A 1 515 ALA 515 509 509 ALA ALA A . n 
A 1 516 LEU 516 510 510 LEU LEU A . n 
A 1 517 ALA 517 511 511 ALA ALA A . n 
A 1 518 ASP 518 512 512 ASP ASP A . n 
A 1 519 VAL 519 513 513 VAL VAL A . n 
A 1 520 PHE 520 514 514 PHE PHE A . n 
A 1 521 VAL 521 515 515 VAL VAL A . n 
A 1 522 LEU 522 516 516 LEU LEU A . n 
A 1 523 LEU 523 517 517 LEU LEU A . n 
A 1 524 ALA 524 518 518 ALA ALA A . n 
A 1 525 LEU 525 519 519 LEU LEU A . n 
A 1 526 ALA 526 520 520 ALA ALA A . n 
A 1 527 HIS 527 521 521 HIS HIS A . n 
A 1 528 ALA 528 522 522 ALA ALA A . n 
A 1 529 THR 529 523 523 THR THR A . n 
A 1 530 ALA 530 524 ?   ?   ?   A . n 
A 1 531 THR 531 525 ?   ?   ?   A . n 
A 1 532 PRO 532 526 ?   ?   ?   A . n 
A 1 533 ASP 533 527 ?   ?   ?   A . n 
A 1 534 PRO 534 528 ?   ?   ?   A . n 
A 1 535 GLU 535 529 ?   ?   ?   A . n 
A 1 536 GLY 536 530 ?   ?   ?   A . n 
A 1 537 CYS 537 531 ?   ?   ?   A . n 
A 1 538 SER 538 532 ?   ?   ?   A . n 
A 1 539 ARG 539 533 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 MG  ? ? MG  ? ? 'SUBJECT OF INVESTIGATION' ? 
2 FPP ? ? FPP ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 FPP 1   601 601 FPP FPP A . 
C 3 MG  1   602 1   MG  MG  A . 
D 3 MG  1   603 2   MG  MG  A . 
E 4 HOH 1   701 217 HOH HOH A . 
E 4 HOH 2   702 157 HOH HOH A . 
E 4 HOH 3   703 127 HOH HOH A . 
E 4 HOH 4   704 185 HOH HOH A . 
E 4 HOH 5   705 120 HOH HOH A . 
E 4 HOH 6   706 89  HOH HOH A . 
E 4 HOH 7   707 126 HOH HOH A . 
E 4 HOH 8   708 75  HOH HOH A . 
E 4 HOH 9   709 33  HOH HOH A . 
E 4 HOH 10  710 53  HOH HOH A . 
E 4 HOH 11  711 199 HOH HOH A . 
E 4 HOH 12  712 140 HOH HOH A . 
E 4 HOH 13  713 166 HOH HOH A . 
E 4 HOH 14  714 135 HOH HOH A . 
E 4 HOH 15  715 68  HOH HOH A . 
E 4 HOH 16  716 216 HOH HOH A . 
E 4 HOH 17  717 134 HOH HOH A . 
E 4 HOH 18  718 8   HOH HOH A . 
E 4 HOH 19  719 110 HOH HOH A . 
E 4 HOH 20  720 13  HOH HOH A . 
E 4 HOH 21  721 187 HOH HOH A . 
E 4 HOH 22  722 69  HOH HOH A . 
E 4 HOH 23  723 21  HOH HOH A . 
E 4 HOH 24  724 28  HOH HOH A . 
E 4 HOH 25  725 112 HOH HOH A . 
E 4 HOH 26  726 83  HOH HOH A . 
E 4 HOH 27  727 40  HOH HOH A . 
E 4 HOH 28  728 58  HOH HOH A . 
E 4 HOH 29  729 50  HOH HOH A . 
E 4 HOH 30  730 177 HOH HOH A . 
E 4 HOH 31  731 96  HOH HOH A . 
E 4 HOH 32  732 142 HOH HOH A . 
E 4 HOH 33  733 11  HOH HOH A . 
E 4 HOH 34  734 39  HOH HOH A . 
E 4 HOH 35  735 122 HOH HOH A . 
E 4 HOH 36  736 65  HOH HOH A . 
E 4 HOH 37  737 10  HOH HOH A . 
E 4 HOH 38  738 60  HOH HOH A . 
E 4 HOH 39  739 47  HOH HOH A . 
E 4 HOH 40  740 77  HOH HOH A . 
E 4 HOH 41  741 147 HOH HOH A . 
E 4 HOH 42  742 74  HOH HOH A . 
E 4 HOH 43  743 176 HOH HOH A . 
E 4 HOH 44  744 144 HOH HOH A . 
E 4 HOH 45  745 143 HOH HOH A . 
E 4 HOH 46  746 95  HOH HOH A . 
E 4 HOH 47  747 162 HOH HOH A . 
E 4 HOH 48  748 59  HOH HOH A . 
E 4 HOH 49  749 32  HOH HOH A . 
E 4 HOH 50  750 6   HOH HOH A . 
E 4 HOH 51  751 42  HOH HOH A . 
E 4 HOH 52  752 146 HOH HOH A . 
E 4 HOH 53  753 52  HOH HOH A . 
E 4 HOH 54  754 78  HOH HOH A . 
E 4 HOH 55  755 87  HOH HOH A . 
E 4 HOH 56  756 3   HOH HOH A . 
E 4 HOH 57  757 18  HOH HOH A . 
E 4 HOH 58  758 71  HOH HOH A . 
E 4 HOH 59  759 99  HOH HOH A . 
E 4 HOH 60  760 203 HOH HOH A . 
E 4 HOH 61  761 51  HOH HOH A . 
E 4 HOH 62  762 45  HOH HOH A . 
E 4 HOH 63  763 43  HOH HOH A . 
E 4 HOH 64  764 103 HOH HOH A . 
E 4 HOH 65  765 154 HOH HOH A . 
E 4 HOH 66  766 179 HOH HOH A . 
E 4 HOH 67  767 121 HOH HOH A . 
E 4 HOH 68  768 170 HOH HOH A . 
E 4 HOH 69  769 49  HOH HOH A . 
E 4 HOH 70  770 92  HOH HOH A . 
E 4 HOH 71  771 5   HOH HOH A . 
E 4 HOH 72  772 125 HOH HOH A . 
E 4 HOH 73  773 20  HOH HOH A . 
E 4 HOH 74  774 91  HOH HOH A . 
E 4 HOH 75  775 153 HOH HOH A . 
E 4 HOH 76  776 70  HOH HOH A . 
E 4 HOH 77  777 183 HOH HOH A . 
E 4 HOH 78  778 35  HOH HOH A . 
E 4 HOH 79  779 111 HOH HOH A . 
E 4 HOH 80  780 119 HOH HOH A . 
E 4 HOH 81  781 38  HOH HOH A . 
E 4 HOH 82  782 133 HOH HOH A . 
E 4 HOH 83  783 204 HOH HOH A . 
E 4 HOH 84  784 62  HOH HOH A . 
E 4 HOH 85  785 190 HOH HOH A . 
E 4 HOH 86  786 225 HOH HOH A . 
E 4 HOH 87  787 88  HOH HOH A . 
E 4 HOH 88  788 108 HOH HOH A . 
E 4 HOH 89  789 220 HOH HOH A . 
E 4 HOH 90  790 164 HOH HOH A . 
E 4 HOH 91  791 161 HOH HOH A . 
E 4 HOH 92  792 19  HOH HOH A . 
E 4 HOH 93  793 9   HOH HOH A . 
E 4 HOH 94  794 209 HOH HOH A . 
E 4 HOH 95  795 98  HOH HOH A . 
E 4 HOH 96  796 229 HOH HOH A . 
E 4 HOH 97  797 61  HOH HOH A . 
E 4 HOH 98  798 184 HOH HOH A . 
E 4 HOH 99  799 29  HOH HOH A . 
E 4 HOH 100 800 102 HOH HOH A . 
E 4 HOH 101 801 23  HOH HOH A . 
E 4 HOH 102 802 54  HOH HOH A . 
E 4 HOH 103 803 80  HOH HOH A . 
E 4 HOH 104 804 178 HOH HOH A . 
E 4 HOH 105 805 55  HOH HOH A . 
E 4 HOH 106 806 116 HOH HOH A . 
E 4 HOH 107 807 30  HOH HOH A . 
E 4 HOH 108 808 141 HOH HOH A . 
E 4 HOH 109 809 137 HOH HOH A . 
E 4 HOH 110 810 139 HOH HOH A . 
E 4 HOH 111 811 211 HOH HOH A . 
E 4 HOH 112 812 26  HOH HOH A . 
E 4 HOH 113 813 171 HOH HOH A . 
E 4 HOH 114 814 85  HOH HOH A . 
E 4 HOH 115 815 15  HOH HOH A . 
E 4 HOH 116 816 100 HOH HOH A . 
E 4 HOH 117 817 131 HOH HOH A . 
E 4 HOH 118 818 192 HOH HOH A . 
E 4 HOH 119 819 230 HOH HOH A . 
E 4 HOH 120 820 145 HOH HOH A . 
E 4 HOH 121 821 41  HOH HOH A . 
E 4 HOH 122 822 106 HOH HOH A . 
E 4 HOH 123 823 198 HOH HOH A . 
E 4 HOH 124 824 215 HOH HOH A . 
E 4 HOH 125 825 76  HOH HOH A . 
E 4 HOH 126 826 226 HOH HOH A . 
E 4 HOH 127 827 86  HOH HOH A . 
E 4 HOH 128 828 46  HOH HOH A . 
E 4 HOH 129 829 79  HOH HOH A . 
E 4 HOH 130 830 114 HOH HOH A . 
E 4 HOH 131 831 214 HOH HOH A . 
E 4 HOH 132 832 224 HOH HOH A . 
E 4 HOH 133 833 113 HOH HOH A . 
E 4 HOH 134 834 34  HOH HOH A . 
E 4 HOH 135 835 27  HOH HOH A . 
E 4 HOH 136 836 37  HOH HOH A . 
E 4 HOH 137 837 182 HOH HOH A . 
E 4 HOH 138 838 66  HOH HOH A . 
E 4 HOH 139 839 94  HOH HOH A . 
E 4 HOH 140 840 7   HOH HOH A . 
E 4 HOH 141 841 14  HOH HOH A . 
E 4 HOH 142 842 84  HOH HOH A . 
E 4 HOH 143 843 151 HOH HOH A . 
E 4 HOH 144 844 25  HOH HOH A . 
E 4 HOH 145 845 174 HOH HOH A . 
E 4 HOH 146 846 197 HOH HOH A . 
E 4 HOH 147 847 180 HOH HOH A . 
E 4 HOH 148 848 132 HOH HOH A . 
E 4 HOH 149 849 107 HOH HOH A . 
E 4 HOH 150 850 81  HOH HOH A . 
E 4 HOH 151 851 124 HOH HOH A . 
E 4 HOH 152 852 123 HOH HOH A . 
E 4 HOH 153 853 138 HOH HOH A . 
E 4 HOH 154 854 101 HOH HOH A . 
E 4 HOH 155 855 57  HOH HOH A . 
E 4 HOH 156 856 128 HOH HOH A . 
E 4 HOH 157 857 155 HOH HOH A . 
E 4 HOH 158 858 208 HOH HOH A . 
E 4 HOH 159 859 188 HOH HOH A . 
E 4 HOH 160 860 152 HOH HOH A . 
E 4 HOH 161 861 63  HOH HOH A . 
E 4 HOH 162 862 149 HOH HOH A . 
E 4 HOH 163 863 4   HOH HOH A . 
E 4 HOH 164 864 218 HOH HOH A . 
E 4 HOH 165 865 228 HOH HOH A . 
E 4 HOH 166 866 82  HOH HOH A . 
E 4 HOH 167 867 212 HOH HOH A . 
E 4 HOH 168 868 48  HOH HOH A . 
E 4 HOH 169 869 168 HOH HOH A . 
E 4 HOH 170 870 165 HOH HOH A . 
E 4 HOH 171 871 156 HOH HOH A . 
E 4 HOH 172 872 173 HOH HOH A . 
E 4 HOH 173 873 210 HOH HOH A . 
E 4 HOH 174 874 200 HOH HOH A . 
E 4 HOH 175 875 118 HOH HOH A . 
E 4 HOH 176 876 73  HOH HOH A . 
E 4 HOH 177 877 115 HOH HOH A . 
E 4 HOH 178 878 186 HOH HOH A . 
E 4 HOH 179 879 130 HOH HOH A . 
E 4 HOH 180 880 64  HOH HOH A . 
E 4 HOH 181 881 72  HOH HOH A . 
E 4 HOH 182 882 129 HOH HOH A . 
E 4 HOH 183 883 167 HOH HOH A . 
E 4 HOH 184 884 17  HOH HOH A . 
E 4 HOH 185 885 175 HOH HOH A . 
E 4 HOH 186 886 205 HOH HOH A . 
E 4 HOH 187 887 105 HOH HOH A . 
E 4 HOH 188 888 201 HOH HOH A . 
E 4 HOH 189 889 196 HOH HOH A . 
E 4 HOH 190 890 160 HOH HOH A . 
E 4 HOH 191 891 117 HOH HOH A . 
E 4 HOH 192 892 202 HOH HOH A . 
E 4 HOH 193 893 97  HOH HOH A . 
E 4 HOH 194 894 136 HOH HOH A . 
E 4 HOH 195 895 221 HOH HOH A . 
E 4 HOH 196 896 206 HOH HOH A . 
E 4 HOH 197 897 181 HOH HOH A . 
E 4 HOH 198 898 222 HOH HOH A . 
E 4 HOH 199 899 194 HOH HOH A . 
E 4 HOH 200 900 189 HOH HOH A . 
E 4 HOH 201 901 12  HOH HOH A . 
E 4 HOH 202 902 24  HOH HOH A . 
E 4 HOH 203 903 219 HOH HOH A . 
E 4 HOH 204 904 193 HOH HOH A . 
E 4 HOH 205 905 104 HOH HOH A . 
E 4 HOH 206 906 22  HOH HOH A . 
E 4 HOH 207 907 213 HOH HOH A . 
E 4 HOH 208 908 31  HOH HOH A . 
E 4 HOH 209 909 207 HOH HOH A . 
E 4 HOH 210 910 195 HOH HOH A . 
E 4 HOH 211 911 227 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? iMOSFLM ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZGW 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     51.320 
_cell.length_a_esd                 ? 
_cell.length_b                     113.880 
_cell.length_b_esd                 ? 
_cell.length_c                     180.089 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZGW 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZGW 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.3 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.6 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'HEPES, NaCl' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-01-27 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97918 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL10U2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97918 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL10U2 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8ZGW 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.23 
_reflns.d_resolution_low                               90.04 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     26244 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.059 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.23 
_reflns_shell.d_res_low                                     2.35 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3730 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.826 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZGW 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.23 
_refine.ls_d_res_low                             54.29 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     26165 
_refine.ls_number_reflns_R_free                  1997 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.85 
_refine.ls_percent_reflns_R_free                 7.63 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1931 
_refine.ls_R_factor_R_free                       0.2454 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1886 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.91 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.26 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        3644 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         26 
_refine_hist.number_atoms_solvent             211 
_refine_hist.number_atoms_total               3881 
_refine_hist.d_res_high                       2.23 
_refine_hist.d_res_low                        54.29 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  ? ?    ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.892  ? ?    ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 15.961 ? 1373 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.046  ? 566  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.009  ? 683  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.23 2.29  . . 138 1666 100.00 . . . . 0.2438 . . . . . . . . . . . 0.2881 
'X-RAY DIFFRACTION' 2.29 2.35  . . 141 1702 100.00 . . . . 0.2151 . . . . . . . . . . . 0.2784 
'X-RAY DIFFRACTION' 2.35 2.42  . . 140 1702 100.00 . . . . 0.2056 . . . . . . . . . . . 0.3210 
'X-RAY DIFFRACTION' 2.42 2.49  . . 139 1696 100.00 . . . . 0.1967 . . . . . . . . . . . 0.2437 
'X-RAY DIFFRACTION' 2.49 2.58  . . 143 1721 100.00 . . . . 0.2044 . . . . . . . . . . . 0.2779 
'X-RAY DIFFRACTION' 2.58 2.69  . . 142 1709 100.00 . . . . 0.2122 . . . . . . . . . . . 0.2668 
'X-RAY DIFFRACTION' 2.69 2.81  . . 141 1711 100.00 . . . . 0.2241 . . . . . . . . . . . 0.3021 
'X-RAY DIFFRACTION' 2.81 2.96  . . 143 1722 100.00 . . . . 0.2226 . . . . . . . . . . . 0.2725 
'X-RAY DIFFRACTION' 2.96 3.14  . . 141 1722 100.00 . . . . 0.2032 . . . . . . . . . . . 0.2907 
'X-RAY DIFFRACTION' 3.14 3.39  . . 143 1725 100.00 . . . . 0.1973 . . . . . . . . . . . 0.2774 
'X-RAY DIFFRACTION' 3.39 3.73  . . 143 1732 100.00 . . . . 0.1742 . . . . . . . . . . . 0.2366 
'X-RAY DIFFRACTION' 3.73 4.26  . . 145 1754 100.00 . . . . 0.1513 . . . . . . . . . . . 0.1822 
'X-RAY DIFFRACTION' 4.27 5.37  . . 146 1768 100.00 . . . . 0.1561 . . . . . . . . . . . 0.1919 
'X-RAY DIFFRACTION' 5.37 54.29 . . 152 1838 99.00  . . . . 0.1793 . . . . . . . . . . . 0.2195 
# 
_struct.entry_id                     8ZGW 
_struct.title                        
'Drimenyl diphosphate synthase SsDMS_F248Y&D303E from Streptomyces showdoensis in complex with farnesyl diphosphate (FPP) and Mg2+' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZGW 
_struct_keywords.text            'Terpene synthases, type II TSs, BIOSYNTHETIC PROTEIN' 
_struct_keywords.pdbx_keywords   'BIOSYNTHETIC PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A2P2GK84_9ACTN 
_struct_ref.pdbx_db_accession          A0A2P2GK84 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MNASPTPTATTTTEPATAVVRCRTRLARRVVAAVGPDGLLPAPCESRVLESALALALLTEERAEADATARLTAYLRTTLR
TAPPDPFQCAVARAVLGGAGERGERVGDEGDMDAGTALDAGLDGFDHFTAGRKRLMFRTVLAALGATGFPAVPWEAYDTR
PQQSWLHMEMKALKVLAAHGTGHPDVVRDEDWRALLPALEPGPAWECNNLAQLLALLALRHSPRHRPALGDVLKHVAGRL
RPDGGMPFIDGMTVFTTAAAGLALSLLPAPPACVTPMADALALRRNPDGGYGFHSGVAQSDVDDTCYVLEFLRRAAPDRH
RTAVAEAEGYLLALRNPDGGFPTFARGTSSEIAMTAAAASALAHDPDRREEVDEAVRYVVRHQRPDGTFERSWSRNATNA
VFRAVLALTGVAAHGEERRSRARAAERALAHLAATQNGDGGWGHAEAEPSDPISTAYAVIALARGPRARPGGPLDRALAY
LVERQHPDGGYRSRPDQAGPRPLLYDVPALADVFVLLALAHATATPDPEGCSR
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8ZGW 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 7 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 539 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A2P2GK84 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  533 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       533 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZGW HIS A 1   ? UNP A0A2P2GK84 ?   ?   'expression tag'      -5  1 
1 8ZGW HIS A 2   ? UNP A0A2P2GK84 ?   ?   'expression tag'      -4  2 
1 8ZGW HIS A 3   ? UNP A0A2P2GK84 ?   ?   'expression tag'      -3  3 
1 8ZGW HIS A 4   ? UNP A0A2P2GK84 ?   ?   'expression tag'      -2  4 
1 8ZGW HIS A 5   ? UNP A0A2P2GK84 ?   ?   'expression tag'      -1  5 
1 8ZGW HIS A 6   ? UNP A0A2P2GK84 ?   ?   'expression tag'      0   6 
1 8ZGW TYR A 254 ? UNP A0A2P2GK84 PHE 248 'engineered mutation' 248 7 
1 8ZGW GLU A 309 ? UNP A0A2P2GK84 ASP 303 'engineered mutation' 303 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 920   ? 
1 MORE         -18   ? 
1 'SSA (A^2)'  19030 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                'The gel filtration suggested the protein is a monomer in solution' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 23  ? VAL A 40  ? THR A 17  VAL A 34  1 ? 18 
HELX_P HELX_P2  AA2 ARG A 53  ? GLU A 67  ? ARG A 47  GLU A 61  1 ? 15 
HELX_P HELX_P3  AA3 GLU A 70  ? ALA A 88  ? GLU A 64  ALA A 82  1 ? 19 
HELX_P HELX_P4  AA4 ASP A 91  ? GLY A 103 ? ASP A 85  GLY A 97  1 ? 13 
HELX_P HELX_P5  AA5 GLY A 137 ? LEU A 150 ? GLY A 131 LEU A 144 1 ? 14 
HELX_P HELX_P6  AA6 PRO A 159 ? ASP A 164 ? PRO A 153 ASP A 158 5 ? 6  
HELX_P HELX_P7  AA7 GLN A 169 ? THR A 187 ? GLN A 163 THR A 181 1 ? 19 
HELX_P HELX_P8  AA8 HIS A 189 ? VAL A 193 ? HIS A 183 VAL A 187 5 ? 5  
HELX_P HELX_P9  AA9 ARG A 194 ? ALA A 200 ? ARG A 188 ALA A 194 1 ? 7  
HELX_P HELX_P10 AB1 LEU A 201 ? GLU A 206 ? LEU A 195 GLU A 200 5 ? 6  
HELX_P HELX_P11 AB2 ALA A 210 ? CYS A 213 ? ALA A 204 CYS A 207 5 ? 4  
HELX_P HELX_P12 AB3 ASN A 214 ? ARG A 226 ? ASN A 208 ARG A 220 1 ? 13 
HELX_P HELX_P13 AB4 HIS A 231 ? PRO A 233 ? HIS A 225 PRO A 227 5 ? 3  
HELX_P HELX_P14 AB5 ALA A 234 ? GLY A 244 ? ALA A 228 GLY A 238 1 ? 11 
HELX_P HELX_P15 AB6 MET A 258 ? LEU A 272 ? MET A 252 LEU A 266 1 ? 15 
HELX_P HELX_P16 AB7 CYS A 279 ? LEU A 289 ? CYS A 273 LEU A 283 1 ? 11 
HELX_P HELX_P17 AB8 ASP A 307 ? ALA A 322 ? ASP A 301 ALA A 316 1 ? 16 
HELX_P HELX_P18 AB9 HIS A 326 ? ARG A 341 ? HIS A 320 ARG A 335 1 ? 16 
HELX_P HELX_P19 AC1 GLU A 357 ? HIS A 370 ? GLU A 351 HIS A 364 1 ? 14 
HELX_P HELX_P20 AC2 ASP A 371 ? ASP A 373 ? ASP A 365 ASP A 367 5 ? 3  
HELX_P HELX_P21 AC3 ARG A 374 ? HIS A 388 ? ARG A 368 HIS A 382 1 ? 15 
HELX_P HELX_P22 AC4 ALA A 403 ? VAL A 417 ? ALA A 397 VAL A 411 1 ? 15 
HELX_P HELX_P23 AC5 GLY A 421 ? GLN A 442 ? GLY A 415 GLN A 436 1 ? 22 
HELX_P HELX_P24 AC6 ASP A 457 ? ALA A 469 ? ASP A 451 ALA A 463 1 ? 13 
HELX_P HELX_P25 AC7 GLY A 478 ? ARG A 490 ? GLY A 472 ARG A 484 1 ? 13 
HELX_P HELX_P26 AC8 ALA A 515 ? THR A 529 ? ALA A 509 THR A 523 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C MG . MG ? ? A GLU 169 A MG 602 1_555 ? ? ? ? ? ? ? 2.857 ? ? 
metalc2 metalc ? ? A GLU 175 OE2 ? ? ? 1_555 D MG . MG ? ? A GLU 169 A MG 603 1_555 ? ? ? ? ? ? ? 2.436 ? ? 
metalc3 metalc ? ? A TYR 254 OH  ? ? ? 1_555 D MG . MG ? ? A TYR 248 A MG 603 1_555 ? ? ? ? ? ? ? 2.950 ? ? 
metalc4 metalc ? ? B FPP .   O1A ? ? ? 1_555 C MG . MG ? ? A FPP 601 A MG 602 1_555 ? ? ? ? ? ? ? 2.847 ? ? 
metalc5 metalc ? ? B FPP .   O2B ? ? ? 1_555 C MG . MG ? ? A FPP 601 A MG 602 1_555 ? ? ? ? ? ? ? 2.856 ? ? 
metalc6 metalc ? ? B FPP .   O1A ? ? ? 1_555 D MG . MG ? ? A FPP 601 A MG 603 1_555 ? ? ? ? ? ? ? 2.924 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 OE1 ? A GLU 175 ? A GLU 169 ? 1_555 MG ? C MG . ? A MG 602 ? 1_555 O1A ? B FPP .   ? A FPP 601 ? 1_555 89.2  ? 
2 OE1 ? A GLU 175 ? A GLU 169 ? 1_555 MG ? C MG . ? A MG 602 ? 1_555 O2B ? B FPP .   ? A FPP 601 ? 1_555 148.2 ? 
3 O1A ? B FPP .   ? A FPP 601 ? 1_555 MG ? C MG . ? A MG 602 ? 1_555 O2B ? B FPP .   ? A FPP 601 ? 1_555 60.6  ? 
4 OE2 ? A GLU 175 ? A GLU 169 ? 1_555 MG ? D MG . ? A MG 603 ? 1_555 OH  ? A TYR 254 ? A TYR 248 ? 1_555 148.8 ? 
5 OE2 ? A GLU 175 ? A GLU 169 ? 1_555 MG ? D MG . ? A MG 603 ? 1_555 O1A ? B FPP .   ? A FPP 601 ? 1_555 120.5 ? 
6 OH  ? A TYR 254 ? A TYR 248 ? 1_555 MG ? D MG . ? A MG 603 ? 1_555 O1A ? B FPP .   ? A FPP 601 ? 1_555 89.7  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 505 A . ? GLY 499 A PRO 506 A ? PRO 500 A 1 -14.80 
2 ARG 507 A . ? ARG 501 A PRO 508 A ? PRO 502 A 1 3.35   
# 
_pdbx_entry_details.entry_id                   8ZGW 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 702 ? ? O   A HOH 791 ? ? 1.99 
2 1 O   A HOH 761 ? ? O   A HOH 865 ? ? 2.08 
3 1 OD1 A ASP 318 ? ? NH2 A ARG 321 ? ? 2.14 
4 1 O   A HOH 776 ? ? O   A HOH 886 ? ? 2.18 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 37  ? ? -69.86  2.27    
2  1 GLU A 64  ? ? 46.34   70.54   
3  1 ALA A 82  ? ? -140.47 56.18   
4  1 PRO A 84  ? ? -85.05  -158.24 
5  1 ALA A 130 ? ? -46.98  153.49  
6  1 GLN A 162 ? ? -146.88 -115.82 
7  1 ALA A 316 ? ? -161.70 45.99   
8  1 PHE A 389 ? ? -127.79 -69.40  
9  1 SER A 392 ? ? -142.66 -100.57 
10 1 ALA A 468 ? ? -58.10  109.81  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A HIS -5  ? A HIS 1   
2  1 Y 1 A HIS -4  ? A HIS 2   
3  1 Y 1 A HIS -3  ? A HIS 3   
4  1 Y 1 A HIS -2  ? A HIS 4   
5  1 Y 1 A HIS -1  ? A HIS 5   
6  1 Y 1 A HIS 0   ? A HIS 6   
7  1 Y 1 A MET 1   ? A MET 7   
8  1 Y 1 A ASN 2   ? A ASN 8   
9  1 Y 1 A ALA 3   ? A ALA 9   
10 1 Y 1 A SER 4   ? A SER 10  
11 1 Y 1 A PRO 5   ? A PRO 11  
12 1 Y 1 A THR 6   ? A THR 12  
13 1 Y 1 A PRO 7   ? A PRO 13  
14 1 Y 1 A THR 8   ? A THR 14  
15 1 Y 1 A ALA 9   ? A ALA 15  
16 1 Y 1 A THR 10  ? A THR 16  
17 1 Y 1 A THR 11  ? A THR 17  
18 1 Y 1 A THR 12  ? A THR 18  
19 1 Y 1 A THR 13  ? A THR 19  
20 1 Y 1 A GLU 14  ? A GLU 20  
21 1 Y 1 A PRO 15  ? A PRO 21  
22 1 Y 1 A GLY 98  ? A GLY 104 
23 1 Y 1 A ALA 99  ? A ALA 105 
24 1 Y 1 A GLY 100 ? A GLY 106 
25 1 Y 1 A GLU 101 ? A GLU 107 
26 1 Y 1 A ARG 102 ? A ARG 108 
27 1 Y 1 A GLY 103 ? A GLY 109 
28 1 Y 1 A GLU 104 ? A GLU 110 
29 1 Y 1 A ARG 105 ? A ARG 111 
30 1 Y 1 A VAL 106 ? A VAL 112 
31 1 Y 1 A GLY 107 ? A GLY 113 
32 1 Y 1 A ASP 108 ? A ASP 114 
33 1 Y 1 A GLU 109 ? A GLU 115 
34 1 Y 1 A GLY 110 ? A GLY 116 
35 1 Y 1 A ASP 111 ? A ASP 117 
36 1 Y 1 A MET 112 ? A MET 118 
37 1 Y 1 A ASP 113 ? A ASP 119 
38 1 Y 1 A ALA 114 ? A ALA 120 
39 1 Y 1 A GLY 115 ? A GLY 121 
40 1 Y 1 A THR 116 ? A THR 122 
41 1 Y 1 A ALA 117 ? A ALA 123 
42 1 Y 1 A LEU 118 ? A LEU 124 
43 1 Y 1 A ASP 119 ? A ASP 125 
44 1 Y 1 A ALA 120 ? A ALA 126 
45 1 Y 1 A GLY 121 ? A GLY 127 
46 1 Y 1 A LEU 122 ? A LEU 128 
47 1 Y 1 A ASP 123 ? A ASP 129 
48 1 Y 1 A ALA 524 ? A ALA 530 
49 1 Y 1 A THR 525 ? A THR 531 
50 1 Y 1 A PRO 526 ? A PRO 532 
51 1 Y 1 A ASP 527 ? A ASP 533 
52 1 Y 1 A PRO 528 ? A PRO 534 
53 1 Y 1 A GLU 529 ? A GLU 535 
54 1 Y 1 A GLY 530 ? A GLY 536 
55 1 Y 1 A CYS 531 ? A CYS 537 
56 1 Y 1 A SER 532 ? A SER 538 
57 1 Y 1 A ARG 533 ? A ARG 539 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
FPP C1   C  N N 88  
FPP O1   O  N N 89  
FPP C2   C  N N 90  
FPP C3   C  N N 91  
FPP C4   C  N N 92  
FPP C5   C  N N 93  
FPP C6   C  N N 94  
FPP C7   C  N N 95  
FPP C8   C  N N 96  
FPP C10  C  N N 97  
FPP C9   C  N N 98  
FPP C11  C  N N 99  
FPP C12  C  N N 100 
FPP C13  C  N N 101 
FPP C14  C  N N 102 
FPP C15  C  N N 103 
FPP PA   P  N R 104 
FPP O1A  O  N N 105 
FPP O2A  O  N N 106 
FPP O3A  O  N N 107 
FPP PB   P  N N 108 
FPP O1B  O  N N 109 
FPP O2B  O  N N 110 
FPP O3B  O  N N 111 
FPP H11  H  N N 112 
FPP H12A H  N N 113 
FPP H2   H  N N 114 
FPP H41  H  N N 115 
FPP H42  H  N N 116 
FPP H43  H  N N 117 
FPP H51  H  N N 118 
FPP H52  H  N N 119 
FPP H61  H  N N 120 
FPP H62  H  N N 121 
FPP H7   H  N N 122 
FPP H101 H  N N 123 
FPP H102 H  N N 124 
FPP H103 H  N N 125 
FPP H91  H  N N 126 
FPP H92  H  N N 127 
FPP H111 H  N N 128 
FPP H112 H  N N 129 
FPP H12  H  N N 130 
FPP H141 H  N N 131 
FPP H142 H  N N 132 
FPP H143 H  N N 133 
FPP H151 H  N N 134 
FPP H152 H  N N 135 
FPP H153 H  N N 136 
FPP HOA2 H  N N 137 
FPP HOB2 H  N N 138 
FPP HOB3 H  N N 139 
GLN N    N  N N 140 
GLN CA   C  N S 141 
GLN C    C  N N 142 
GLN O    O  N N 143 
GLN CB   C  N N 144 
GLN CG   C  N N 145 
GLN CD   C  N N 146 
GLN OE1  O  N N 147 
GLN NE2  N  N N 148 
GLN OXT  O  N N 149 
GLN H    H  N N 150 
GLN H2   H  N N 151 
GLN HA   H  N N 152 
GLN HB2  H  N N 153 
GLN HB3  H  N N 154 
GLN HG2  H  N N 155 
GLN HG3  H  N N 156 
GLN HE21 H  N N 157 
GLN HE22 H  N N 158 
GLN HXT  H  N N 159 
GLU N    N  N N 160 
GLU CA   C  N S 161 
GLU C    C  N N 162 
GLU O    O  N N 163 
GLU CB   C  N N 164 
GLU CG   C  N N 165 
GLU CD   C  N N 166 
GLU OE1  O  N N 167 
GLU OE2  O  N N 168 
GLU OXT  O  N N 169 
GLU H    H  N N 170 
GLU H2   H  N N 171 
GLU HA   H  N N 172 
GLU HB2  H  N N 173 
GLU HB3  H  N N 174 
GLU HG2  H  N N 175 
GLU HG3  H  N N 176 
GLU HE2  H  N N 177 
GLU HXT  H  N N 178 
GLY N    N  N N 179 
GLY CA   C  N N 180 
GLY C    C  N N 181 
GLY O    O  N N 182 
GLY OXT  O  N N 183 
GLY H    H  N N 184 
GLY H2   H  N N 185 
GLY HA2  H  N N 186 
GLY HA3  H  N N 187 
GLY HXT  H  N N 188 
HIS N    N  N N 189 
HIS CA   C  N S 190 
HIS C    C  N N 191 
HIS O    O  N N 192 
HIS CB   C  N N 193 
HIS CG   C  Y N 194 
HIS ND1  N  Y N 195 
HIS CD2  C  Y N 196 
HIS CE1  C  Y N 197 
HIS NE2  N  Y N 198 
HIS OXT  O  N N 199 
HIS H    H  N N 200 
HIS H2   H  N N 201 
HIS HA   H  N N 202 
HIS HB2  H  N N 203 
HIS HB3  H  N N 204 
HIS HD1  H  N N 205 
HIS HD2  H  N N 206 
HIS HE1  H  N N 207 
HIS HE2  H  N N 208 
HIS HXT  H  N N 209 
HOH O    O  N N 210 
HOH H1   H  N N 211 
HOH H2   H  N N 212 
ILE N    N  N N 213 
ILE CA   C  N S 214 
ILE C    C  N N 215 
ILE O    O  N N 216 
ILE CB   C  N S 217 
ILE CG1  C  N N 218 
ILE CG2  C  N N 219 
ILE CD1  C  N N 220 
ILE OXT  O  N N 221 
ILE H    H  N N 222 
ILE H2   H  N N 223 
ILE HA   H  N N 224 
ILE HB   H  N N 225 
ILE HG12 H  N N 226 
ILE HG13 H  N N 227 
ILE HG21 H  N N 228 
ILE HG22 H  N N 229 
ILE HG23 H  N N 230 
ILE HD11 H  N N 231 
ILE HD12 H  N N 232 
ILE HD13 H  N N 233 
ILE HXT  H  N N 234 
LEU N    N  N N 235 
LEU CA   C  N S 236 
LEU C    C  N N 237 
LEU O    O  N N 238 
LEU CB   C  N N 239 
LEU CG   C  N N 240 
LEU CD1  C  N N 241 
LEU CD2  C  N N 242 
LEU OXT  O  N N 243 
LEU H    H  N N 244 
LEU H2   H  N N 245 
LEU HA   H  N N 246 
LEU HB2  H  N N 247 
LEU HB3  H  N N 248 
LEU HG   H  N N 249 
LEU HD11 H  N N 250 
LEU HD12 H  N N 251 
LEU HD13 H  N N 252 
LEU HD21 H  N N 253 
LEU HD22 H  N N 254 
LEU HD23 H  N N 255 
LEU HXT  H  N N 256 
LYS N    N  N N 257 
LYS CA   C  N S 258 
LYS C    C  N N 259 
LYS O    O  N N 260 
LYS CB   C  N N 261 
LYS CG   C  N N 262 
LYS CD   C  N N 263 
LYS CE   C  N N 264 
LYS NZ   N  N N 265 
LYS OXT  O  N N 266 
LYS H    H  N N 267 
LYS H2   H  N N 268 
LYS HA   H  N N 269 
LYS HB2  H  N N 270 
LYS HB3  H  N N 271 
LYS HG2  H  N N 272 
LYS HG3  H  N N 273 
LYS HD2  H  N N 274 
LYS HD3  H  N N 275 
LYS HE2  H  N N 276 
LYS HE3  H  N N 277 
LYS HZ1  H  N N 278 
LYS HZ2  H  N N 279 
LYS HZ3  H  N N 280 
LYS HXT  H  N N 281 
MET N    N  N N 282 
MET CA   C  N S 283 
MET C    C  N N 284 
MET O    O  N N 285 
MET CB   C  N N 286 
MET CG   C  N N 287 
MET SD   S  N N 288 
MET CE   C  N N 289 
MET OXT  O  N N 290 
MET H    H  N N 291 
MET H2   H  N N 292 
MET HA   H  N N 293 
MET HB2  H  N N 294 
MET HB3  H  N N 295 
MET HG2  H  N N 296 
MET HG3  H  N N 297 
MET HE1  H  N N 298 
MET HE2  H  N N 299 
MET HE3  H  N N 300 
MET HXT  H  N N 301 
MG  MG   MG N N 302 
PHE N    N  N N 303 
PHE CA   C  N S 304 
PHE C    C  N N 305 
PHE O    O  N N 306 
PHE CB   C  N N 307 
PHE CG   C  Y N 308 
PHE CD1  C  Y N 309 
PHE CD2  C  Y N 310 
PHE CE1  C  Y N 311 
PHE CE2  C  Y N 312 
PHE CZ   C  Y N 313 
PHE OXT  O  N N 314 
PHE H    H  N N 315 
PHE H2   H  N N 316 
PHE HA   H  N N 317 
PHE HB2  H  N N 318 
PHE HB3  H  N N 319 
PHE HD1  H  N N 320 
PHE HD2  H  N N 321 
PHE HE1  H  N N 322 
PHE HE2  H  N N 323 
PHE HZ   H  N N 324 
PHE HXT  H  N N 325 
PRO N    N  N N 326 
PRO CA   C  N S 327 
PRO C    C  N N 328 
PRO O    O  N N 329 
PRO CB   C  N N 330 
PRO CG   C  N N 331 
PRO CD   C  N N 332 
PRO OXT  O  N N 333 
PRO H    H  N N 334 
PRO HA   H  N N 335 
PRO HB2  H  N N 336 
PRO HB3  H  N N 337 
PRO HG2  H  N N 338 
PRO HG3  H  N N 339 
PRO HD2  H  N N 340 
PRO HD3  H  N N 341 
PRO HXT  H  N N 342 
SER N    N  N N 343 
SER CA   C  N S 344 
SER C    C  N N 345 
SER O    O  N N 346 
SER CB   C  N N 347 
SER OG   O  N N 348 
SER OXT  O  N N 349 
SER H    H  N N 350 
SER H2   H  N N 351 
SER HA   H  N N 352 
SER HB2  H  N N 353 
SER HB3  H  N N 354 
SER HG   H  N N 355 
SER HXT  H  N N 356 
THR N    N  N N 357 
THR CA   C  N S 358 
THR C    C  N N 359 
THR O    O  N N 360 
THR CB   C  N R 361 
THR OG1  O  N N 362 
THR CG2  C  N N 363 
THR OXT  O  N N 364 
THR H    H  N N 365 
THR H2   H  N N 366 
THR HA   H  N N 367 
THR HB   H  N N 368 
THR HG1  H  N N 369 
THR HG21 H  N N 370 
THR HG22 H  N N 371 
THR HG23 H  N N 372 
THR HXT  H  N N 373 
TRP N    N  N N 374 
TRP CA   C  N S 375 
TRP C    C  N N 376 
TRP O    O  N N 377 
TRP CB   C  N N 378 
TRP CG   C  Y N 379 
TRP CD1  C  Y N 380 
TRP CD2  C  Y N 381 
TRP NE1  N  Y N 382 
TRP CE2  C  Y N 383 
TRP CE3  C  Y N 384 
TRP CZ2  C  Y N 385 
TRP CZ3  C  Y N 386 
TRP CH2  C  Y N 387 
TRP OXT  O  N N 388 
TRP H    H  N N 389 
TRP H2   H  N N 390 
TRP HA   H  N N 391 
TRP HB2  H  N N 392 
TRP HB3  H  N N 393 
TRP HD1  H  N N 394 
TRP HE1  H  N N 395 
TRP HE3  H  N N 396 
TRP HZ2  H  N N 397 
TRP HZ3  H  N N 398 
TRP HH2  H  N N 399 
TRP HXT  H  N N 400 
TYR N    N  N N 401 
TYR CA   C  N S 402 
TYR C    C  N N 403 
TYR O    O  N N 404 
TYR CB   C  N N 405 
TYR CG   C  Y N 406 
TYR CD1  C  Y N 407 
TYR CD2  C  Y N 408 
TYR CE1  C  Y N 409 
TYR CE2  C  Y N 410 
TYR CZ   C  Y N 411 
TYR OH   O  N N 412 
TYR OXT  O  N N 413 
TYR H    H  N N 414 
TYR H2   H  N N 415 
TYR HA   H  N N 416 
TYR HB2  H  N N 417 
TYR HB3  H  N N 418 
TYR HD1  H  N N 419 
TYR HD2  H  N N 420 
TYR HE1  H  N N 421 
TYR HE2  H  N N 422 
TYR HH   H  N N 423 
TYR HXT  H  N N 424 
VAL N    N  N N 425 
VAL CA   C  N S 426 
VAL C    C  N N 427 
VAL O    O  N N 428 
VAL CB   C  N N 429 
VAL CG1  C  N N 430 
VAL CG2  C  N N 431 
VAL OXT  O  N N 432 
VAL H    H  N N 433 
VAL H2   H  N N 434 
VAL HA   H  N N 435 
VAL HB   H  N N 436 
VAL HG11 H  N N 437 
VAL HG12 H  N N 438 
VAL HG13 H  N N 439 
VAL HG21 H  N N 440 
VAL HG22 H  N N 441 
VAL HG23 H  N N 442 
VAL HXT  H  N N 443 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
FPP C1  O1   sing N N 83  
FPP C1  C2   sing N N 84  
FPP C1  H11  sing N N 85  
FPP C1  H12A sing N N 86  
FPP O1  PA   sing N N 87  
FPP C2  C3   doub N E 88  
FPP C2  H2   sing N N 89  
FPP C3  C4   sing N N 90  
FPP C3  C5   sing N N 91  
FPP C4  H41  sing N N 92  
FPP C4  H42  sing N N 93  
FPP C4  H43  sing N N 94  
FPP C5  C6   sing N N 95  
FPP C5  H51  sing N N 96  
FPP C5  H52  sing N N 97  
FPP C6  C7   sing N N 98  
FPP C6  H61  sing N N 99  
FPP C6  H62  sing N N 100 
FPP C7  C8   doub N E 101 
FPP C7  H7   sing N N 102 
FPP C8  C10  sing N N 103 
FPP C8  C9   sing N N 104 
FPP C10 H101 sing N N 105 
FPP C10 H102 sing N N 106 
FPP C10 H103 sing N N 107 
FPP C9  C11  sing N N 108 
FPP C9  H91  sing N N 109 
FPP C9  H92  sing N N 110 
FPP C11 C12  sing N N 111 
FPP C11 H111 sing N N 112 
FPP C11 H112 sing N N 113 
FPP C12 C13  doub N N 114 
FPP C12 H12  sing N N 115 
FPP C13 C14  sing N N 116 
FPP C13 C15  sing N N 117 
FPP C14 H141 sing N N 118 
FPP C14 H142 sing N N 119 
FPP C14 H143 sing N N 120 
FPP C15 H151 sing N N 121 
FPP C15 H152 sing N N 122 
FPP C15 H153 sing N N 123 
FPP PA  O1A  doub N N 124 
FPP PA  O2A  sing N N 125 
FPP PA  O3A  sing N N 126 
FPP O2A HOA2 sing N N 127 
FPP O3A PB   sing N N 128 
FPP PB  O1B  doub N N 129 
FPP PB  O2B  sing N N 130 
FPP PB  O3B  sing N N 131 
FPP O2B HOB2 sing N N 132 
FPP O3B HOB3 sing N N 133 
GLN N   CA   sing N N 134 
GLN N   H    sing N N 135 
GLN N   H2   sing N N 136 
GLN CA  C    sing N N 137 
GLN CA  CB   sing N N 138 
GLN CA  HA   sing N N 139 
GLN C   O    doub N N 140 
GLN C   OXT  sing N N 141 
GLN CB  CG   sing N N 142 
GLN CB  HB2  sing N N 143 
GLN CB  HB3  sing N N 144 
GLN CG  CD   sing N N 145 
GLN CG  HG2  sing N N 146 
GLN CG  HG3  sing N N 147 
GLN CD  OE1  doub N N 148 
GLN CD  NE2  sing N N 149 
GLN NE2 HE21 sing N N 150 
GLN NE2 HE22 sing N N 151 
GLN OXT HXT  sing N N 152 
GLU N   CA   sing N N 153 
GLU N   H    sing N N 154 
GLU N   H2   sing N N 155 
GLU CA  C    sing N N 156 
GLU CA  CB   sing N N 157 
GLU CA  HA   sing N N 158 
GLU C   O    doub N N 159 
GLU C   OXT  sing N N 160 
GLU CB  CG   sing N N 161 
GLU CB  HB2  sing N N 162 
GLU CB  HB3  sing N N 163 
GLU CG  CD   sing N N 164 
GLU CG  HG2  sing N N 165 
GLU CG  HG3  sing N N 166 
GLU CD  OE1  doub N N 167 
GLU CD  OE2  sing N N 168 
GLU OE2 HE2  sing N N 169 
GLU OXT HXT  sing N N 170 
GLY N   CA   sing N N 171 
GLY N   H    sing N N 172 
GLY N   H2   sing N N 173 
GLY CA  C    sing N N 174 
GLY CA  HA2  sing N N 175 
GLY CA  HA3  sing N N 176 
GLY C   O    doub N N 177 
GLY C   OXT  sing N N 178 
GLY OXT HXT  sing N N 179 
HIS N   CA   sing N N 180 
HIS N   H    sing N N 181 
HIS N   H2   sing N N 182 
HIS CA  C    sing N N 183 
HIS CA  CB   sing N N 184 
HIS CA  HA   sing N N 185 
HIS C   O    doub N N 186 
HIS C   OXT  sing N N 187 
HIS CB  CG   sing N N 188 
HIS CB  HB2  sing N N 189 
HIS CB  HB3  sing N N 190 
HIS CG  ND1  sing Y N 191 
HIS CG  CD2  doub Y N 192 
HIS ND1 CE1  doub Y N 193 
HIS ND1 HD1  sing N N 194 
HIS CD2 NE2  sing Y N 195 
HIS CD2 HD2  sing N N 196 
HIS CE1 NE2  sing Y N 197 
HIS CE1 HE1  sing N N 198 
HIS NE2 HE2  sing N N 199 
HIS OXT HXT  sing N N 200 
HOH O   H1   sing N N 201 
HOH O   H2   sing N N 202 
ILE N   CA   sing N N 203 
ILE N   H    sing N N 204 
ILE N   H2   sing N N 205 
ILE CA  C    sing N N 206 
ILE CA  CB   sing N N 207 
ILE CA  HA   sing N N 208 
ILE C   O    doub N N 209 
ILE C   OXT  sing N N 210 
ILE CB  CG1  sing N N 211 
ILE CB  CG2  sing N N 212 
ILE CB  HB   sing N N 213 
ILE CG1 CD1  sing N N 214 
ILE CG1 HG12 sing N N 215 
ILE CG1 HG13 sing N N 216 
ILE CG2 HG21 sing N N 217 
ILE CG2 HG22 sing N N 218 
ILE CG2 HG23 sing N N 219 
ILE CD1 HD11 sing N N 220 
ILE CD1 HD12 sing N N 221 
ILE CD1 HD13 sing N N 222 
ILE OXT HXT  sing N N 223 
LEU N   CA   sing N N 224 
LEU N   H    sing N N 225 
LEU N   H2   sing N N 226 
LEU CA  C    sing N N 227 
LEU CA  CB   sing N N 228 
LEU CA  HA   sing N N 229 
LEU C   O    doub N N 230 
LEU C   OXT  sing N N 231 
LEU CB  CG   sing N N 232 
LEU CB  HB2  sing N N 233 
LEU CB  HB3  sing N N 234 
LEU CG  CD1  sing N N 235 
LEU CG  CD2  sing N N 236 
LEU CG  HG   sing N N 237 
LEU CD1 HD11 sing N N 238 
LEU CD1 HD12 sing N N 239 
LEU CD1 HD13 sing N N 240 
LEU CD2 HD21 sing N N 241 
LEU CD2 HD22 sing N N 242 
LEU CD2 HD23 sing N N 243 
LEU OXT HXT  sing N N 244 
LYS N   CA   sing N N 245 
LYS N   H    sing N N 246 
LYS N   H2   sing N N 247 
LYS CA  C    sing N N 248 
LYS CA  CB   sing N N 249 
LYS CA  HA   sing N N 250 
LYS C   O    doub N N 251 
LYS C   OXT  sing N N 252 
LYS CB  CG   sing N N 253 
LYS CB  HB2  sing N N 254 
LYS CB  HB3  sing N N 255 
LYS CG  CD   sing N N 256 
LYS CG  HG2  sing N N 257 
LYS CG  HG3  sing N N 258 
LYS CD  CE   sing N N 259 
LYS CD  HD2  sing N N 260 
LYS CD  HD3  sing N N 261 
LYS CE  NZ   sing N N 262 
LYS CE  HE2  sing N N 263 
LYS CE  HE3  sing N N 264 
LYS NZ  HZ1  sing N N 265 
LYS NZ  HZ2  sing N N 266 
LYS NZ  HZ3  sing N N 267 
LYS OXT HXT  sing N N 268 
MET N   CA   sing N N 269 
MET N   H    sing N N 270 
MET N   H2   sing N N 271 
MET CA  C    sing N N 272 
MET CA  CB   sing N N 273 
MET CA  HA   sing N N 274 
MET C   O    doub N N 275 
MET C   OXT  sing N N 276 
MET CB  CG   sing N N 277 
MET CB  HB2  sing N N 278 
MET CB  HB3  sing N N 279 
MET CG  SD   sing N N 280 
MET CG  HG2  sing N N 281 
MET CG  HG3  sing N N 282 
MET SD  CE   sing N N 283 
MET CE  HE1  sing N N 284 
MET CE  HE2  sing N N 285 
MET CE  HE3  sing N N 286 
MET OXT HXT  sing N N 287 
PHE N   CA   sing N N 288 
PHE N   H    sing N N 289 
PHE N   H2   sing N N 290 
PHE CA  C    sing N N 291 
PHE CA  CB   sing N N 292 
PHE CA  HA   sing N N 293 
PHE C   O    doub N N 294 
PHE C   OXT  sing N N 295 
PHE CB  CG   sing N N 296 
PHE CB  HB2  sing N N 297 
PHE CB  HB3  sing N N 298 
PHE CG  CD1  doub Y N 299 
PHE CG  CD2  sing Y N 300 
PHE CD1 CE1  sing Y N 301 
PHE CD1 HD1  sing N N 302 
PHE CD2 CE2  doub Y N 303 
PHE CD2 HD2  sing N N 304 
PHE CE1 CZ   doub Y N 305 
PHE CE1 HE1  sing N N 306 
PHE CE2 CZ   sing Y N 307 
PHE CE2 HE2  sing N N 308 
PHE CZ  HZ   sing N N 309 
PHE OXT HXT  sing N N 310 
PRO N   CA   sing N N 311 
PRO N   CD   sing N N 312 
PRO N   H    sing N N 313 
PRO CA  C    sing N N 314 
PRO CA  CB   sing N N 315 
PRO CA  HA   sing N N 316 
PRO C   O    doub N N 317 
PRO C   OXT  sing N N 318 
PRO CB  CG   sing N N 319 
PRO CB  HB2  sing N N 320 
PRO CB  HB3  sing N N 321 
PRO CG  CD   sing N N 322 
PRO CG  HG2  sing N N 323 
PRO CG  HG3  sing N N 324 
PRO CD  HD2  sing N N 325 
PRO CD  HD3  sing N N 326 
PRO OXT HXT  sing N N 327 
SER N   CA   sing N N 328 
SER N   H    sing N N 329 
SER N   H2   sing N N 330 
SER CA  C    sing N N 331 
SER CA  CB   sing N N 332 
SER CA  HA   sing N N 333 
SER C   O    doub N N 334 
SER C   OXT  sing N N 335 
SER CB  OG   sing N N 336 
SER CB  HB2  sing N N 337 
SER CB  HB3  sing N N 338 
SER OG  HG   sing N N 339 
SER OXT HXT  sing N N 340 
THR N   CA   sing N N 341 
THR N   H    sing N N 342 
THR N   H2   sing N N 343 
THR CA  C    sing N N 344 
THR CA  CB   sing N N 345 
THR CA  HA   sing N N 346 
THR C   O    doub N N 347 
THR C   OXT  sing N N 348 
THR CB  OG1  sing N N 349 
THR CB  CG2  sing N N 350 
THR CB  HB   sing N N 351 
THR OG1 HG1  sing N N 352 
THR CG2 HG21 sing N N 353 
THR CG2 HG22 sing N N 354 
THR CG2 HG23 sing N N 355 
THR OXT HXT  sing N N 356 
TRP N   CA   sing N N 357 
TRP N   H    sing N N 358 
TRP N   H2   sing N N 359 
TRP CA  C    sing N N 360 
TRP CA  CB   sing N N 361 
TRP CA  HA   sing N N 362 
TRP C   O    doub N N 363 
TRP C   OXT  sing N N 364 
TRP CB  CG   sing N N 365 
TRP CB  HB2  sing N N 366 
TRP CB  HB3  sing N N 367 
TRP CG  CD1  doub Y N 368 
TRP CG  CD2  sing Y N 369 
TRP CD1 NE1  sing Y N 370 
TRP CD1 HD1  sing N N 371 
TRP CD2 CE2  doub Y N 372 
TRP CD2 CE3  sing Y N 373 
TRP NE1 CE2  sing Y N 374 
TRP NE1 HE1  sing N N 375 
TRP CE2 CZ2  sing Y N 376 
TRP CE3 CZ3  doub Y N 377 
TRP CE3 HE3  sing N N 378 
TRP CZ2 CH2  doub Y N 379 
TRP CZ2 HZ2  sing N N 380 
TRP CZ3 CH2  sing Y N 381 
TRP CZ3 HZ3  sing N N 382 
TRP CH2 HH2  sing N N 383 
TRP OXT HXT  sing N N 384 
TYR N   CA   sing N N 385 
TYR N   H    sing N N 386 
TYR N   H2   sing N N 387 
TYR CA  C    sing N N 388 
TYR CA  CB   sing N N 389 
TYR CA  HA   sing N N 390 
TYR C   O    doub N N 391 
TYR C   OXT  sing N N 392 
TYR CB  CG   sing N N 393 
TYR CB  HB2  sing N N 394 
TYR CB  HB3  sing N N 395 
TYR CG  CD1  doub Y N 396 
TYR CG  CD2  sing Y N 397 
TYR CD1 CE1  sing Y N 398 
TYR CD1 HD1  sing N N 399 
TYR CD2 CE2  doub Y N 400 
TYR CD2 HD2  sing N N 401 
TYR CE1 CZ   doub Y N 402 
TYR CE1 HE1  sing N N 403 
TYR CE2 CZ   sing Y N 404 
TYR CE2 HE2  sing N N 405 
TYR CZ  OH   sing N N 406 
TYR OH  HH   sing N N 407 
TYR OXT HXT  sing N N 408 
VAL N   CA   sing N N 409 
VAL N   H    sing N N 410 
VAL N   H2   sing N N 411 
VAL CA  C    sing N N 412 
VAL CA  CB   sing N N 413 
VAL CA  HA   sing N N 414 
VAL C   O    doub N N 415 
VAL C   OXT  sing N N 416 
VAL CB  CG1  sing N N 417 
VAL CB  CG2  sing N N 418 
VAL CB  HB   sing N N 419 
VAL CG1 HG11 sing N N 420 
VAL CG1 HG12 sing N N 421 
VAL CG1 HG13 sing N N 422 
VAL CG2 HG21 sing N N 423 
VAL CG2 HG22 sing N N 424 
VAL CG2 HG23 sing N N 425 
VAL OXT HXT  sing N N 426 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           82073746 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7XR7 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8ZGW 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019486 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008781 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005553 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
MG 
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ALA A 1 22  ? -4.300  -37.172 -31.194 1.00 38.89 ? 16  ALA A N   1 
ATOM   2    C  CA  . ALA A 1 22  ? -5.592  -36.813 -31.783 1.00 50.56 ? 16  ALA A CA  1 
ATOM   3    C  C   . ALA A 1 22  ? -5.449  -35.725 -32.874 1.00 48.97 ? 16  ALA A C   1 
ATOM   4    O  O   . ALA A 1 22  ? -4.360  -35.534 -33.435 1.00 42.46 ? 16  ALA A O   1 
ATOM   5    C  CB  . ALA A 1 22  ? -6.564  -36.355 -30.682 1.00 42.14 ? 16  ALA A CB  1 
ATOM   6    N  N   . THR A 1 23  ? -6.546  -35.021 -33.163 1.00 42.22 ? 17  THR A N   1 
ATOM   7    C  CA  . THR A 1 23  ? -6.545  -33.976 -34.180 1.00 33.45 ? 17  THR A CA  1 
ATOM   8    C  C   . THR A 1 23  ? -5.719  -32.774 -33.736 1.00 32.84 ? 17  THR A C   1 
ATOM   9    O  O   . THR A 1 23  ? -5.461  -32.559 -32.547 1.00 32.91 ? 17  THR A O   1 
ATOM   10   C  CB  . THR A 1 23  ? -7.972  -33.501 -34.481 1.00 37.67 ? 17  THR A CB  1 
ATOM   11   O  OG1 . THR A 1 23  ? -8.534  -32.917 -33.292 1.00 37.00 ? 17  THR A OG1 1 
ATOM   12   C  CG2 . THR A 1 23  ? -8.854  -34.649 -34.943 1.00 32.57 ? 17  THR A CG2 1 
ATOM   13   N  N   . ALA A 1 24  ? -5.333  -31.953 -34.715 1.00 32.57 ? 18  ALA A N   1 
ATOM   14   C  CA  . ALA A 1 24  ? -4.632  -30.716 -34.389 1.00 32.38 ? 18  ALA A CA  1 
ATOM   15   C  C   . ALA A 1 24  ? -5.480  -29.815 -33.498 1.00 26.13 ? 18  ALA A C   1 
ATOM   16   O  O   . ALA A 1 24  ? -4.936  -29.023 -32.728 1.00 23.69 ? 18  ALA A O   1 
ATOM   17   C  CB  . ALA A 1 24  ? -4.243  -29.977 -35.664 1.00 30.54 ? 18  ALA A CB  1 
ATOM   18   N  N   . VAL A 1 25  ? -6.806  -29.941 -33.587 1.00 26.82 ? 19  VAL A N   1 
ATOM   19   C  CA  . VAL A 1 25  ? -7.725  -29.132 -32.792 1.00 28.95 ? 19  VAL A CA  1 
ATOM   20   C  C   . VAL A 1 25  ? -7.638  -29.515 -31.316 1.00 29.91 ? 19  VAL A C   1 
ATOM   21   O  O   . VAL A 1 25  ? -7.565  -28.654 -30.428 1.00 20.97 ? 19  VAL A O   1 
ATOM   22   C  CB  . VAL A 1 25  ? -9.157  -29.299 -33.330 1.00 23.49 ? 19  VAL A CB  1 
ATOM   23   C  CG1 . VAL A 1 25  ? -10.150 -28.568 -32.441 1.00 25.52 ? 19  VAL A CG1 1 
ATOM   24   C  CG2 . VAL A 1 25  ? -9.247  -28.787 -34.763 1.00 27.99 ? 19  VAL A CG2 1 
ATOM   25   N  N   . VAL A 1 26  ? -7.670  -30.816 -31.036 1.00 25.73 ? 20  VAL A N   1 
ATOM   26   C  CA  . VAL A 1 26  ? -7.602  -31.274 -29.659 1.00 25.08 ? 20  VAL A CA  1 
ATOM   27   C  C   . VAL A 1 26  ? -6.256  -30.912 -29.055 1.00 25.00 ? 20  VAL A C   1 
ATOM   28   O  O   . VAL A 1 26  ? -6.172  -30.518 -27.886 1.00 27.07 ? 20  VAL A O   1 
ATOM   29   C  CB  . VAL A 1 26  ? -7.876  -32.786 -29.588 1.00 29.35 ? 20  VAL A CB  1 
ATOM   30   C  CG1 . VAL A 1 26  ? -7.196  -33.377 -28.361 1.00 34.05 ? 20  VAL A CG1 1 
ATOM   31   C  CG2 . VAL A 1 26  ? -9.381  -33.051 -29.577 1.00 25.60 ? 20  VAL A CG2 1 
ATOM   32   N  N   . ARG A 1 27  ? -5.185  -31.013 -29.845 1.00 26.21 ? 21  ARG A N   1 
ATOM   33   C  CA  . ARG A 1 27  ? -3.870  -30.609 -29.358 1.00 25.43 ? 21  ARG A CA  1 
ATOM   34   C  C   . ARG A 1 27  ? -3.844  -29.129 -29.030 1.00 29.03 ? 21  ARG A C   1 
ATOM   35   O  O   . ARG A 1 27  ? -3.313  -28.724 -27.986 1.00 22.80 ? 21  ARG A O   1 
ATOM   36   C  CB  . ARG A 1 27  ? -2.791  -30.944 -30.383 1.00 32.22 ? 21  ARG A CB  1 
ATOM   37   C  CG  . ARG A 1 27  ? -2.093  -32.271 -30.093 1.00 40.83 ? 21  ARG A CG  1 
ATOM   38   C  CD  . ARG A 1 27  ? -2.057  -33.183 -31.297 1.00 38.73 ? 21  ARG A CD  1 
ATOM   39   N  NE  . ARG A 1 27  ? -1.386  -32.555 -32.428 1.00 46.46 ? 21  ARG A NE  1 
ATOM   40   C  CZ  . ARG A 1 27  ? -1.651  -32.836 -33.698 1.00 46.45 ? 21  ARG A CZ  1 
ATOM   41   N  NH1 . ARG A 1 27  ? -2.560  -33.742 -34.031 1.00 44.52 ? 21  ARG A NH1 1 
ATOM   42   N  NH2 . ARG A 1 27  ? -0.988  -32.195 -34.658 1.00 37.52 ? 21  ARG A NH2 1 
ATOM   43   N  N   . CYS A 1 28  ? -4.413  -28.307 -29.917 1.00 25.86 ? 22  CYS A N   1 
ATOM   44   C  CA  . CYS A 1 28  ? -4.551  -26.882 -29.651 1.00 22.21 ? 22  CYS A CA  1 
ATOM   45   C  C   . CYS A 1 28  ? -5.385  -26.637 -28.394 1.00 22.60 ? 22  CYS A C   1 
ATOM   46   O  O   . CYS A 1 28  ? -4.990  -25.869 -27.516 1.00 21.64 ? 22  CYS A O   1 
ATOM   47   C  CB  . CYS A 1 28  ? -5.176  -26.205 -30.867 1.00 22.88 ? 22  CYS A CB  1 
ATOM   48   S  SG  . CYS A 1 28  ? -5.639  -24.509 -30.655 1.00 26.73 ? 22  CYS A SG  1 
ATOM   49   N  N   . ARG A 1 29  ? -6.535  -27.306 -28.283 1.00 21.47 ? 23  ARG A N   1 
ATOM   50   C  CA  . ARG A 1 29  ? -7.356  -27.188 -27.087 1.00 23.01 ? 23  ARG A CA  1 
ATOM   51   C  C   . ARG A 1 29  ? -6.551  -27.493 -25.825 1.00 24.20 ? 23  ARG A C   1 
ATOM   52   O  O   . ARG A 1 29  ? -6.592  -26.735 -24.842 1.00 19.26 ? 23  ARG A O   1 
ATOM   53   C  CB  . ARG A 1 29  ? -8.561  -28.125 -27.192 1.00 20.26 ? 23  ARG A CB  1 
ATOM   54   C  CG  . ARG A 1 29  ? -9.640  -27.841 -26.158 1.00 21.11 ? 23  ARG A CG  1 
ATOM   55   C  CD  . ARG A 1 29  ? -10.659 -28.962 -26.113 1.00 23.25 ? 23  ARG A CD  1 
ATOM   56   N  NE  . ARG A 1 29  ? -10.083 -30.211 -25.634 1.00 23.83 ? 23  ARG A NE  1 
ATOM   57   C  CZ  . ARG A 1 29  ? -10.638 -31.400 -25.819 1.00 26.03 ? 23  ARG A CZ  1 
ATOM   58   N  NH1 . ARG A 1 29  ? -11.769 -31.537 -26.492 1.00 24.92 ? 23  ARG A NH1 1 
ATOM   59   N  NH2 . ARG A 1 29  ? -10.057 -32.474 -25.298 1.00 25.96 ? 23  ARG A NH2 1 
ATOM   60   N  N   . THR A 1 30  ? -5.795  -28.597 -25.852 1.00 22.69 ? 24  THR A N   1 
ATOM   61   C  CA  . THR A 1 30  ? -5.031  -29.046 -24.689 1.00 19.39 ? 24  THR A CA  1 
ATOM   62   C  C   . THR A 1 30  ? -3.977  -28.028 -24.277 1.00 21.84 ? 24  THR A C   1 
ATOM   63   O  O   . THR A 1 30  ? -3.898  -27.647 -23.102 1.00 24.87 ? 24  THR A O   1 
ATOM   64   C  CB  . THR A 1 30  ? -4.367  -30.392 -24.994 1.00 28.74 ? 24  THR A CB  1 
ATOM   65   O  OG1 . THR A 1 30  ? -5.374  -31.359 -25.297 1.00 21.43 ? 24  THR A OG1 1 
ATOM   66   C  CG2 . THR A 1 30  ? -3.556  -30.865 -23.785 1.00 23.39 ? 24  THR A CG2 1 
ATOM   67   N  N   . ARG A 1 31  ? -3.140  -27.582 -25.215 1.00 19.74 ? 25  ARG A N   1 
ATOM   68   C  CA  . ARG A 1 31  ? -2.144  -26.576 -24.840 1.00 21.78 ? 25  ARG A CA  1 
ATOM   69   C  C   . ARG A 1 31  ? -2.814  -25.350 -24.244 1.00 21.22 ? 25  ARG A C   1 
ATOM   70   O  O   . ARG A 1 31  ? -2.282  -24.739 -23.312 1.00 20.83 ? 25  ARG A O   1 
ATOM   71   C  CB  . ARG A 1 31  ? -1.287  -26.169 -26.034 1.00 21.41 ? 25  ARG A CB  1 
ATOM   72   C  CG  . ARG A 1 31  ? -0.461  -27.294 -26.595 1.00 25.83 ? 25  ARG A CG  1 
ATOM   73   C  CD  . ARG A 1 31  ? 0.306   -26.901 -27.859 1.00 27.41 ? 25  ARG A CD  1 
ATOM   74   N  NE  . ARG A 1 31  ? 1.019   -25.633 -27.768 1.00 33.68 ? 25  ARG A NE  1 
ATOM   75   C  CZ  . ARG A 1 31  ? 1.122   -24.761 -28.768 1.00 39.70 ? 25  ARG A CZ  1 
ATOM   76   N  NH1 . ARG A 1 31  ? 0.564   -24.997 -29.953 1.00 39.12 ? 25  ARG A NH1 1 
ATOM   77   N  NH2 . ARG A 1 31  ? 1.818   -23.637 -28.584 1.00 24.40 ? 25  ARG A NH2 1 
ATOM   78   N  N   . LEU A 1 32  ? -3.981  -24.975 -24.771 1.00 19.62 ? 26  LEU A N   1 
ATOM   79   C  CA  . LEU A 1 32  ? -4.664  -23.783 -24.284 1.00 19.68 ? 26  LEU A CA  1 
ATOM   80   C  C   . LEU A 1 32  ? -5.198  -24.000 -22.867 1.00 17.93 ? 26  LEU A C   1 
ATOM   81   O  O   . LEU A 1 32  ? -4.977  -23.175 -21.982 1.00 20.60 ? 26  LEU A O   1 
ATOM   82   C  CB  . LEU A 1 32  ? -5.793  -23.401 -25.251 1.00 17.91 ? 26  LEU A CB  1 
ATOM   83   C  CG  . LEU A 1 32  ? -6.558  -22.121 -24.881 1.00 20.93 ? 26  LEU A CG  1 
ATOM   84   C  CD1 . LEU A 1 32  ? -5.605  -20.955 -24.667 1.00 21.42 ? 26  LEU A CD1 1 
ATOM   85   C  CD2 . LEU A 1 32  ? -7.641  -21.757 -25.916 1.00 13.88 ? 26  LEU A CD2 1 
ATOM   86   N  N   . ALA A 1 33  ? -5.892  -25.122 -22.633 1.00 20.03 ? 27  ALA A N   1 
ATOM   87   C  CA  . ALA A 1 33  ? -6.405  -25.444 -21.303 1.00 18.59 ? 27  ALA A CA  1 
ATOM   88   C  C   . ALA A 1 33  ? -5.295  -25.471 -20.261 1.00 21.03 ? 27  ALA A C   1 
ATOM   89   O  O   . ALA A 1 33  ? -5.495  -25.026 -19.126 1.00 22.19 ? 27  ALA A O   1 
ATOM   90   C  CB  . ALA A 1 33  ? -7.122  -26.794 -21.316 1.00 16.85 ? 27  ALA A CB  1 
ATOM   91   N  N   . ARG A 1 34  ? -4.139  -26.036 -20.605 1.00 21.02 ? 28  ARG A N   1 
ATOM   92   C  CA  . ARG A 1 34  ? -3.008  -26.011 -19.681 1.00 23.13 ? 28  ARG A CA  1 
ATOM   93   C  C   . ARG A 1 34  ? -2.660  -24.575 -19.302 1.00 24.40 ? 28  ARG A C   1 
ATOM   94   O  O   . ARG A 1 34  ? -2.412  -24.265 -18.129 1.00 22.20 ? 28  ARG A O   1 
ATOM   95   C  CB  . ARG A 1 34  ? -1.798  -26.710 -20.311 1.00 17.32 ? 28  ARG A CB  1 
ATOM   96   C  CG  . ARG A 1 34  ? -1.954  -28.231 -20.486 1.00 22.48 ? 28  ARG A CG  1 
ATOM   97   C  CD  . ARG A 1 34  ? -0.707  -28.834 -21.124 1.00 19.10 ? 28  ARG A CD  1 
ATOM   98   N  NE  . ARG A 1 34  ? -0.845  -30.269 -21.348 1.00 24.52 ? 28  ARG A NE  1 
ATOM   99   C  CZ  . ARG A 1 34  ? 0.031   -31.006 -22.019 1.00 25.57 ? 28  ARG A CZ  1 
ATOM   100  N  NH1 . ARG A 1 34  ? 1.117   -30.472 -22.553 1.00 23.60 ? 28  ARG A NH1 1 
ATOM   101  N  NH2 . ARG A 1 34  ? -0.191  -32.312 -22.160 1.00 28.70 ? 28  ARG A NH2 1 
ATOM   102  N  N   . ARG A 1 35  ? -2.627  -23.688 -20.294 1.00 22.48 ? 29  ARG A N   1 
ATOM   103  C  CA  . ARG A 1 35  ? -2.277  -22.300 -20.039 1.00 23.09 ? 29  ARG A CA  1 
ATOM   104  C  C   . ARG A 1 35  ? -3.318  -21.625 -19.150 1.00 20.81 ? 29  ARG A C   1 
ATOM   105  O  O   . ARG A 1 35  ? -2.976  -20.946 -18.178 1.00 22.66 ? 29  ARG A O   1 
ATOM   106  C  CB  . ARG A 1 35  ? -2.129  -21.580 -21.367 1.00 27.24 ? 29  ARG A CB  1 
ATOM   107  C  CG  . ARG A 1 35  ? -1.663  -20.164 -21.232 1.00 29.06 ? 29  ARG A CG  1 
ATOM   108  C  CD  . ARG A 1 35  ? -1.577  -19.526 -22.600 1.00 25.53 ? 29  ARG A CD  1 
ATOM   109  N  NE  . ARG A 1 35  ? -1.318  -18.106 -22.444 1.00 27.63 ? 29  ARG A NE  1 
ATOM   110  C  CZ  . ARG A 1 35  ? -0.130  -17.603 -22.143 1.00 33.25 ? 29  ARG A CZ  1 
ATOM   111  N  NH1 . ARG A 1 35  ? 0.947   -18.372 -22.064 1.00 29.62 ? 29  ARG A NH1 1 
ATOM   112  N  NH2 . ARG A 1 35  ? -0.022  -16.298 -21.910 1.00 29.54 ? 29  ARG A NH2 1 
ATOM   113  N  N   . VAL A 1 36  ? -4.600  -21.827 -19.453 1.00 21.04 ? 30  VAL A N   1 
ATOM   114  C  CA  . VAL A 1 36  ? -5.655  -21.223 -18.644 1.00 20.66 ? 30  VAL A CA  1 
ATOM   115  C  C   . VAL A 1 36  ? -5.625  -21.777 -17.215 1.00 23.98 ? 30  VAL A C   1 
ATOM   116  O  O   . VAL A 1 36  ? -5.748  -21.021 -16.244 1.00 22.01 ? 30  VAL A O   1 
ATOM   117  C  CB  . VAL A 1 36  ? -7.023  -21.424 -19.331 1.00 20.74 ? 30  VAL A CB  1 
ATOM   118  C  CG1 . VAL A 1 36  ? -8.142  -20.922 -18.451 1.00 18.25 ? 30  VAL A CG1 1 
ATOM   119  C  CG2 . VAL A 1 36  ? -7.051  -20.676 -20.697 1.00 18.05 ? 30  VAL A CG2 1 
ATOM   120  N  N   . VAL A 1 37  ? -5.440  -23.091 -17.055 1.00 18.87 ? 31  VAL A N   1 
ATOM   121  C  CA  . VAL A 1 37  ? -5.362  -23.657 -15.710 1.00 22.29 ? 31  VAL A CA  1 
ATOM   122  C  C   . VAL A 1 37  ? -4.201  -23.042 -14.948 1.00 21.95 ? 31  VAL A C   1 
ATOM   123  O  O   . VAL A 1 37  ? -4.349  -22.613 -13.800 1.00 21.29 ? 31  VAL A O   1 
ATOM   124  C  CB  . VAL A 1 37  ? -5.239  -25.187 -15.756 1.00 22.42 ? 31  VAL A CB  1 
ATOM   125  C  CG1 . VAL A 1 37  ? -4.775  -25.700 -14.377 1.00 20.71 ? 31  VAL A CG1 1 
ATOM   126  C  CG2 . VAL A 1 37  ? -6.568  -25.810 -16.154 1.00 20.33 ? 31  VAL A CG2 1 
ATOM   127  N  N   . ALA A 1 38  ? -3.025  -22.988 -15.576 1.00 24.95 ? 32  ALA A N   1 
ATOM   128  C  CA  . ALA A 1 38  ? -1.863  -22.418 -14.900 1.00 25.62 ? 32  ALA A CA  1 
ATOM   129  C  C   . ALA A 1 38  ? -2.110  -20.977 -14.464 1.00 22.93 ? 32  ALA A C   1 
ATOM   130  O  O   . ALA A 1 38  ? -1.544  -20.533 -13.459 1.00 23.06 ? 32  ALA A O   1 
ATOM   131  C  CB  . ALA A 1 38  ? -0.625  -22.483 -15.804 1.00 21.20 ? 32  ALA A CB  1 
ATOM   132  N  N   . ALA A 1 39  ? -2.929  -20.225 -15.204 1.00 19.84 ? 33  ALA A N   1 
ATOM   133  C  CA  . ALA A 1 39  ? -3.083  -18.811 -14.870 1.00 22.89 ? 33  ALA A CA  1 
ATOM   134  C  C   . ALA A 1 39  ? -4.082  -18.569 -13.736 1.00 20.85 ? 33  ALA A C   1 
ATOM   135  O  O   . ALA A 1 39  ? -4.142  -17.455 -13.208 1.00 23.73 ? 33  ALA A O   1 
ATOM   136  C  CB  . ALA A 1 39  ? -3.485  -18.012 -16.115 1.00 18.00 ? 33  ALA A CB  1 
ATOM   137  N  N   . VAL A 1 40  ? -4.868  -19.570 -13.349 1.00 19.37 ? 34  VAL A N   1 
ATOM   138  C  CA  . VAL A 1 40  ? -5.748  -19.430 -12.200 1.00 20.10 ? 34  VAL A CA  1 
ATOM   139  C  C   . VAL A 1 40  ? -4.920  -19.478 -10.929 1.00 21.83 ? 34  VAL A C   1 
ATOM   140  O  O   . VAL A 1 40  ? -4.118  -20.402 -10.728 1.00 21.76 ? 34  VAL A O   1 
ATOM   141  C  CB  . VAL A 1 40  ? -6.812  -20.532 -12.218 1.00 20.12 ? 34  VAL A CB  1 
ATOM   142  C  CG1 . VAL A 1 40  ? -7.700  -20.408 -11.015 1.00 20.33 ? 34  VAL A CG1 1 
ATOM   143  C  CG2 . VAL A 1 40  ? -7.626  -20.430 -13.513 1.00 17.84 ? 34  VAL A CG2 1 
ATOM   144  N  N   . GLY A 1 41  ? -5.107  -18.492 -10.061 1.00 20.90 ? 35  GLY A N   1 
ATOM   145  C  CA  . GLY A 1 41  ? -4.372  -18.427 -8.810  1.00 22.93 ? 35  GLY A CA  1 
ATOM   146  C  C   . GLY A 1 41  ? -4.967  -19.327 -7.744  1.00 26.73 ? 35  GLY A C   1 
ATOM   147  O  O   . GLY A 1 41  ? -6.095  -19.846 -7.867  1.00 22.98 ? 35  GLY A O   1 
ATOM   148  N  N   . PRO A 1 42  ? -4.209  -19.520 -6.651  1.00 26.88 ? 36  PRO A N   1 
ATOM   149  C  CA  . PRO A 1 42  ? -4.718  -20.345 -5.539  1.00 28.95 ? 36  PRO A CA  1 
ATOM   150  C  C   . PRO A 1 42  ? -5.911  -19.729 -4.827  1.00 26.43 ? 36  PRO A C   1 
ATOM   151  O  O   . PRO A 1 42  ? -6.681  -20.467 -4.202  1.00 31.41 ? 36  PRO A O   1 
ATOM   152  C  CB  . PRO A 1 42  ? -3.512  -20.464 -4.600  1.00 31.10 ? 36  PRO A CB  1 
ATOM   153  C  CG  . PRO A 1 42  ? -2.694  -19.231 -4.894  1.00 30.62 ? 36  PRO A CG  1 
ATOM   154  C  CD  . PRO A 1 42  ? -2.888  -18.930 -6.352  1.00 25.72 ? 36  PRO A CD  1 
ATOM   155  N  N   . ASP A 1 43  ? -6.099  -18.411 -4.906  1.00 25.52 ? 37  ASP A N   1 
ATOM   156  C  CA  . ASP A 1 43  ? -7.370  -17.832 -4.487  1.00 24.06 ? 37  ASP A CA  1 
ATOM   157  C  C   . ASP A 1 43  ? -8.509  -18.182 -5.432  1.00 22.22 ? 37  ASP A C   1 
ATOM   158  O  O   . ASP A 1 43  ? -9.639  -17.727 -5.215  1.00 19.96 ? 37  ASP A O   1 
ATOM   159  C  CB  . ASP A 1 43  ? -7.258  -16.315 -4.361  1.00 21.67 ? 37  ASP A CB  1 
ATOM   160  C  CG  . ASP A 1 43  ? -6.987  -15.611 -5.692  1.00 28.91 ? 37  ASP A CG  1 
ATOM   161  O  OD1 . ASP A 1 43  ? -6.765  -16.261 -6.739  1.00 27.33 ? 37  ASP A OD1 1 
ATOM   162  O  OD2 . ASP A 1 43  ? -6.977  -14.364 -5.677  1.00 35.38 ? 37  ASP A OD2 1 
ATOM   163  N  N   . GLY A 1 44  ? -8.248  -18.980 -6.464  1.00 20.24 ? 38  GLY A N   1 
ATOM   164  C  CA  . GLY A 1 44  ? -9.294  -19.382 -7.379  1.00 16.80 ? 38  GLY A CA  1 
ATOM   165  C  C   . GLY A 1 44  ? -9.700  -18.354 -8.406  1.00 16.08 ? 38  GLY A C   1 
ATOM   166  O  O   . GLY A 1 44  ? -10.752 -18.516 -9.033  1.00 20.84 ? 38  GLY A O   1 
ATOM   167  N  N   . LEU A 1 45  ? -8.909  -17.303 -8.614  1.00 17.11 ? 39  LEU A N   1 
ATOM   168  C  CA  . LEU A 1 45  ? -9.266  -16.242 -9.548  1.00 21.67 ? 39  LEU A CA  1 
ATOM   169  C  C   . LEU A 1 45  ? -8.291  -16.214 -10.714 1.00 18.75 ? 39  LEU A C   1 
ATOM   170  O  O   . LEU A 1 45  ? -7.081  -16.356 -10.526 1.00 20.05 ? 39  LEU A O   1 
ATOM   171  C  CB  . LEU A 1 45  ? -9.270  -14.858 -8.868  1.00 16.30 ? 39  LEU A CB  1 
ATOM   172  C  CG  . LEU A 1 45  ? -10.454 -14.486 -7.964  1.00 18.75 ? 39  LEU A CG  1 
ATOM   173  C  CD1 . LEU A 1 45  ? -10.361 -13.020 -7.549  1.00 17.48 ? 39  LEU A CD1 1 
ATOM   174  C  CD2 . LEU A 1 45  ? -11.793 -14.773 -8.614  1.00 16.33 ? 39  LEU A CD2 1 
ATOM   175  N  N   . LEU A 1 46  ? -8.816  -15.963 -11.910 1.00 18.24 ? 40  LEU A N   1 
ATOM   176  C  CA  . LEU A 1 46  ? -7.972  -15.707 -13.068 1.00 16.51 ? 40  LEU A CA  1 
ATOM   177  C  C   . LEU A 1 46  ? -7.777  -14.202 -13.172 1.00 17.84 ? 40  LEU A C   1 
ATOM   178  O  O   . LEU A 1 46  ? -8.745  -13.486 -13.467 1.00 18.21 ? 40  LEU A O   1 
ATOM   179  C  CB  . LEU A 1 46  ? -8.623  -16.259 -14.332 1.00 20.39 ? 40  LEU A CB  1 
ATOM   180  C  CG  . LEU A 1 46  ? -7.786  -16.390 -15.612 1.00 24.55 ? 40  LEU A CG  1 
ATOM   181  C  CD1 . LEU A 1 46  ? -6.593  -17.287 -15.353 1.00 25.92 ? 40  LEU A CD1 1 
ATOM   182  C  CD2 . LEU A 1 46  ? -8.613  -17.003 -16.733 1.00 21.31 ? 40  LEU A CD2 1 
ATOM   183  N  N   . PRO A 1 47  ? -6.575  -13.669 -12.911 1.00 16.36 ? 41  PRO A N   1 
ATOM   184  C  CA  . PRO A 1 47  ? -6.395  -12.210 -12.953 1.00 19.69 ? 41  PRO A CA  1 
ATOM   185  C  C   . PRO A 1 47  ? -6.636  -11.684 -14.354 1.00 19.30 ? 41  PRO A C   1 
ATOM   186  O  O   . PRO A 1 47  ? -6.234  -12.292 -15.346 1.00 17.16 ? 41  PRO A O   1 
ATOM   187  C  CB  . PRO A 1 47  ? -4.933  -12.004 -12.524 1.00 18.21 ? 41  PRO A CB  1 
ATOM   188  C  CG  . PRO A 1 47  ? -4.544  -13.335 -11.833 1.00 20.95 ? 41  PRO A CG  1 
ATOM   189  C  CD  . PRO A 1 47  ? -5.323  -14.372 -12.582 1.00 18.99 ? 41  PRO A CD  1 
ATOM   190  N  N   . ALA A 1 48  ? -7.295  -10.541 -14.430 1.00 16.58 ? 42  ALA A N   1 
ATOM   191  C  CA  . ALA A 1 48  ? -7.747  -9.990  -15.704 1.00 18.56 ? 42  ALA A CA  1 
ATOM   192  C  C   . ALA A 1 48  ? -7.564  -8.484  -15.674 1.00 16.30 ? 42  ALA A C   1 
ATOM   193  O  O   . ALA A 1 48  ? -8.534  -7.725  -15.713 1.00 19.14 ? 42  ALA A O   1 
ATOM   194  C  CB  . ALA A 1 48  ? -9.205  -10.377 -15.963 1.00 11.84 ? 42  ALA A CB  1 
ATOM   195  N  N   . PRO A 1 49  ? -6.322  -8.013  -15.583 1.00 19.43 ? 43  PRO A N   1 
ATOM   196  C  CA  . PRO A 1 49  ? -6.080  -6.569  -15.620 1.00 18.27 ? 43  PRO A CA  1 
ATOM   197  C  C   . PRO A 1 49  ? -6.474  -5.961  -16.952 1.00 22.74 ? 43  PRO A C   1 
ATOM   198  O  O   . PRO A 1 49  ? -6.384  -6.584  -18.017 1.00 19.71 ? 43  PRO A O   1 
ATOM   199  C  CB  . PRO A 1 49  ? -4.572  -6.450  -15.394 1.00 22.85 ? 43  PRO A CB  1 
ATOM   200  C  CG  . PRO A 1 49  ? -4.027  -7.798  -15.787 1.00 18.69 ? 43  PRO A CG  1 
ATOM   201  C  CD  . PRO A 1 49  ? -5.078  -8.771  -15.366 1.00 18.33 ? 43  PRO A CD  1 
ATOM   202  N  N   . CYS A 1 50  ? -6.895  -4.710  -16.880 1.00 21.15 ? 44  CYS A N   1 
ATOM   203  C  CA  . CYS A 1 50  ? -7.179  -3.924  -18.066 1.00 20.63 ? 44  CYS A CA  1 
ATOM   204  C  C   . CYS A 1 50  ? -5.940  -3.108  -18.428 1.00 20.59 ? 44  CYS A C   1 
ATOM   205  O  O   . CYS A 1 50  ? -5.229  -2.620  -17.542 1.00 22.56 ? 44  CYS A O   1 
ATOM   206  C  CB  . CYS A 1 50  ? -8.396  -3.027  -17.811 1.00 16.50 ? 44  CYS A CB  1 
ATOM   207  S  SG  . CYS A 1 50  ? -8.798  -1.878  -19.128 1.00 19.06 ? 44  CYS A SG  1 
ATOM   208  N  N   . GLU A 1 51  ? -5.665  -2.995  -19.728 1.00 18.66 ? 45  GLU A N   1 
ATOM   209  C  CA  . GLU A 1 51  ? -4.540  -2.209  -20.219 1.00 23.14 ? 45  GLU A CA  1 
ATOM   210  C  C   . GLU A 1 51  ? -4.829  -0.713  -20.104 1.00 21.60 ? 45  GLU A C   1 
ATOM   211  O  O   . GLU A 1 51  ? -5.975  -0.286  -19.956 1.00 20.30 ? 45  GLU A O   1 
ATOM   212  C  CB  . GLU A 1 51  ? -4.244  -2.524  -21.690 1.00 23.63 ? 45  GLU A CB  1 
ATOM   213  C  CG  . GLU A 1 51  ? -3.740  -3.931  -21.957 1.00 25.61 ? 45  GLU A CG  1 
ATOM   214  C  CD  . GLU A 1 51  ? -2.420  -4.226  -21.285 1.00 31.73 ? 45  GLU A CD  1 
ATOM   215  O  OE1 . GLU A 1 51  ? -1.375  -3.736  -21.766 1.00 40.38 ? 45  GLU A OE1 1 
ATOM   216  O  OE2 . GLU A 1 51  ? -2.434  -4.937  -20.248 1.00 46.21 ? 45  GLU A OE2 1 
ATOM   217  N  N   . SER A 1 52  ? -3.758  0.080   -20.206 1.00 19.95 ? 46  SER A N   1 
ATOM   218  C  CA  . SER A 1 52  ? -3.861  1.527   -20.315 1.00 21.45 ? 46  SER A CA  1 
ATOM   219  C  C   . SER A 1 52  ? -4.757  1.920   -21.485 1.00 23.95 ? 46  SER A C   1 
ATOM   220  O  O   . SER A 1 52  ? -4.799  1.249   -22.522 1.00 18.79 ? 46  SER A O   1 
ATOM   221  C  CB  . SER A 1 52  ? -2.465  2.143   -20.492 1.00 22.67 ? 46  SER A CB  1 
ATOM   222  O  OG  . SER A 1 52  ? -1.662  1.960   -19.322 1.00 23.77 ? 46  SER A OG  1 
ATOM   223  N  N   . ARG A 1 53  ? -5.487  3.026   -21.321 1.00 21.52 ? 47  ARG A N   1 
ATOM   224  C  CA  . ARG A 1 53  ? -6.316  3.544   -22.399 1.00 20.25 ? 47  ARG A CA  1 
ATOM   225  C  C   . ARG A 1 53  ? -6.045  5.028   -22.582 1.00 21.42 ? 47  ARG A C   1 
ATOM   226  O  O   . ARG A 1 53  ? -5.855  5.756   -21.605 1.00 23.50 ? 47  ARG A O   1 
ATOM   227  C  CB  . ARG A 1 53  ? -7.803  3.307   -22.126 1.00 19.82 ? 47  ARG A CB  1 
ATOM   228  C  CG  . ARG A 1 53  ? -8.671  3.623   -23.318 1.00 20.39 ? 47  ARG A CG  1 
ATOM   229  C  CD  . ARG A 1 53  ? -9.919  2.800   -23.294 1.00 21.34 ? 47  ARG A CD  1 
ATOM   230  N  NE  . ARG A 1 53  ? -10.902 3.373   -22.394 1.00 23.88 ? 47  ARG A NE  1 
ATOM   231  C  CZ  . ARG A 1 53  ? -12.196 3.101   -22.444 1.00 25.34 ? 47  ARG A CZ  1 
ATOM   232  N  NH1 . ARG A 1 53  ? -12.685 2.245   -23.327 1.00 22.47 ? 47  ARG A NH1 1 
ATOM   233  N  NH2 . ARG A 1 53  ? -13.020 3.704   -21.587 1.00 22.39 ? 47  ARG A NH2 1 
ATOM   234  N  N   . VAL A 1 54  ? -6.033  5.471   -23.839 1.00 21.83 ? 48  VAL A N   1 
ATOM   235  C  CA  . VAL A 1 54  ? -5.725  6.868   -24.133 1.00 21.71 ? 48  VAL A CA  1 
ATOM   236  C  C   . VAL A 1 54  ? -6.672  7.795   -23.375 1.00 21.48 ? 48  VAL A C   1 
ATOM   237  O  O   . VAL A 1 54  ? -6.242  8.774   -22.757 1.00 20.23 ? 48  VAL A O   1 
ATOM   238  C  CB  . VAL A 1 54  ? -5.773  7.119   -25.652 1.00 20.45 ? 48  VAL A CB  1 
ATOM   239  C  CG1 . VAL A 1 54  ? -6.110  8.573   -25.965 1.00 19.78 ? 48  VAL A CG1 1 
ATOM   240  C  CG2 . VAL A 1 54  ? -4.445  6.727   -26.299 1.00 22.07 ? 48  VAL A CG2 1 
ATOM   241  N  N   . LEU A 1 55  ? -7.972  7.489   -23.399 1.00 19.17 ? 49  LEU A N   1 
ATOM   242  C  CA  . LEU A 1 55  ? -8.958  8.401   -22.829 1.00 21.29 ? 49  LEU A CA  1 
ATOM   243  C  C   . LEU A 1 55  ? -8.657  8.712   -21.365 1.00 20.86 ? 49  LEU A C   1 
ATOM   244  O  O   . LEU A 1 55  ? -8.574  9.883   -20.977 1.00 23.10 ? 49  LEU A O   1 
ATOM   245  C  CB  . LEU A 1 55  ? -10.364 7.822   -22.980 1.00 22.07 ? 49  LEU A CB  1 
ATOM   246  C  CG  . LEU A 1 55  ? -11.446 8.594   -22.235 1.00 19.99 ? 49  LEU A CG  1 
ATOM   247  C  CD1 . LEU A 1 55  ? -11.485 10.036  -22.734 1.00 21.62 ? 49  LEU A CD1 1 
ATOM   248  C  CD2 . LEU A 1 55  ? -12.784 7.906   -22.388 1.00 19.74 ? 49  LEU A CD2 1 
ATOM   249  N  N   . GLU A 1 56  ? -8.499  7.681   -20.530 1.00 17.17 ? 50  GLU A N   1 
ATOM   250  C  CA  . GLU A 1 56  ? -8.317  7.930   -19.098 1.00 20.77 ? 50  GLU A CA  1 
ATOM   251  C  C   . GLU A 1 56  ? -6.940  8.492   -18.805 1.00 21.57 ? 50  GLU A C   1 
ATOM   252  O  O   . GLU A 1 56  ? -6.781  9.298   -17.881 1.00 21.06 ? 50  GLU A O   1 
ATOM   253  C  CB  . GLU A 1 56  ? -8.527  6.648   -18.282 1.00 20.96 ? 50  GLU A CB  1 
ATOM   254  C  CG  . GLU A 1 56  ? -9.952  6.239   -18.177 1.00 19.33 ? 50  GLU A CG  1 
ATOM   255  C  CD  . GLU A 1 56  ? -10.424 5.569   -19.450 1.00 26.34 ? 50  GLU A CD  1 
ATOM   256  O  OE1 . GLU A 1 56  ? -9.556  5.266   -20.316 1.00 26.43 ? 50  GLU A OE1 1 
ATOM   257  O  OE2 . GLU A 1 56  ? -11.653 5.350   -19.584 1.00 29.04 ? 50  GLU A OE2 1 
ATOM   258  N  N   . SER A 1 57  ? -5.926  8.036   -19.544 1.00 21.82 ? 51  SER A N   1 
ATOM   259  C  CA  . SER A 1 57  ? -4.596  8.633   -19.430 1.00 23.34 ? 51  SER A CA  1 
ATOM   260  C  C   . SER A 1 57  ? -4.651  10.129  -19.700 1.00 22.17 ? 51  SER A C   1 
ATOM   261  O  O   . SER A 1 57  ? -4.052  10.927  -18.968 1.00 25.23 ? 51  SER A O   1 
ATOM   262  C  CB  . SER A 1 57  ? -3.623  7.953   -20.402 1.00 21.63 ? 51  SER A CB  1 
ATOM   263  O  OG  . SER A 1 57  ? -3.502  6.562   -20.126 1.00 19.38 ? 51  SER A OG  1 
ATOM   264  N  N   . ALA A 1 58  ? -5.361  10.522  -20.757 1.00 24.73 ? 52  ALA A N   1 
ATOM   265  C  CA  . ALA A 1 58  ? -5.533  11.931  -21.071 1.00 23.76 ? 52  ALA A CA  1 
ATOM   266  C  C   . ALA A 1 58  ? -6.229  12.660  -19.933 1.00 24.22 ? 52  ALA A C   1 
ATOM   267  O  O   . ALA A 1 58  ? -5.780  13.724  -19.498 1.00 25.28 ? 52  ALA A O   1 
ATOM   268  C  CB  . ALA A 1 58  ? -6.322  12.076  -22.368 1.00 21.09 ? 52  ALA A CB  1 
ATOM   269  N  N   . LEU A 1 59  ? -7.343  12.107  -19.441 1.00 22.92 ? 53  LEU A N   1 
ATOM   270  C  CA  . LEU A 1 59  ? -8.043  12.749  -18.336 1.00 20.05 ? 53  LEU A CA  1 
ATOM   271  C  C   . LEU A 1 59  ? -7.152  12.831  -17.108 1.00 21.51 ? 53  LEU A C   1 
ATOM   272  O  O   . LEU A 1 59  ? -7.082  13.879  -16.453 1.00 20.59 ? 53  LEU A O   1 
ATOM   273  C  CB  . LEU A 1 59  ? -9.337  11.997  -18.010 1.00 18.17 ? 53  LEU A CB  1 
ATOM   274  C  CG  . LEU A 1 59  ? -10.391 12.123  -19.100 1.00 22.54 ? 53  LEU A CG  1 
ATOM   275  C  CD1 . LEU A 1 59  ? -11.596 11.224  -18.799 1.00 14.36 ? 53  LEU A CD1 1 
ATOM   276  C  CD2 . LEU A 1 59  ? -10.791 13.603  -19.268 1.00 20.55 ? 53  LEU A CD2 1 
ATOM   277  N  N   . ALA A 1 60  ? -6.475  11.732  -16.765 1.00 18.65 ? 54  ALA A N   1 
ATOM   278  C  CA  . ALA A 1 60  ? -5.521  11.796  -15.663 1.00 19.73 ? 54  ALA A CA  1 
ATOM   279  C  C   . ALA A 1 60  ? -4.481  12.873  -15.917 1.00 24.51 ? 54  ALA A C   1 
ATOM   280  O  O   . ALA A 1 60  ? -4.113  13.616  -14.997 1.00 23.50 ? 54  ALA A O   1 
ATOM   281  C  CB  . ALA A 1 60  ? -4.847  10.447  -15.447 1.00 18.07 ? 54  ALA A CB  1 
ATOM   282  N  N   . LEU A 1 61  ? -4.015  13.003  -17.166 1.00 23.83 ? 55  LEU A N   1 
ATOM   283  C  CA  . LEU A 1 61  ? -2.994  14.008  -17.454 1.00 23.03 ? 55  LEU A CA  1 
ATOM   284  C  C   . LEU A 1 61  ? -3.525  15.406  -17.175 1.00 22.01 ? 55  LEU A C   1 
ATOM   285  O  O   . LEU A 1 61  ? -2.888  16.196  -16.470 1.00 22.24 ? 55  LEU A O   1 
ATOM   286  C  CB  . LEU A 1 61  ? -2.512  13.900  -18.901 1.00 24.49 ? 55  LEU A CB  1 
ATOM   287  C  CG  . LEU A 1 61  ? -1.295  14.788  -19.211 1.00 25.31 ? 55  LEU A CG  1 
ATOM   288  C  CD1 . LEU A 1 61  ? -0.142  14.446  -18.275 1.00 26.59 ? 55  LEU A CD1 1 
ATOM   289  C  CD2 . LEU A 1 61  ? -0.845  14.657  -20.666 1.00 25.85 ? 55  LEU A CD2 1 
ATOM   290  N  N   . ALA A 1 62  ? -4.699  15.721  -17.723 1.00 19.88 ? 56  ALA A N   1 
ATOM   291  C  CA  . ALA A 1 62  ? -5.335  17.008  -17.467 1.00 22.34 ? 56  ALA A CA  1 
ATOM   292  C  C   . ALA A 1 62  ? -5.521  17.258  -15.968 1.00 27.69 ? 56  ALA A C   1 
ATOM   293  O  O   . ALA A 1 62  ? -5.115  18.304  -15.442 1.00 27.45 ? 56  ALA A O   1 
ATOM   294  C  CB  . ALA A 1 62  ? -6.679  17.064  -18.198 1.00 23.71 ? 56  ALA A CB  1 
ATOM   295  N  N   . LEU A 1 63  ? -6.133  16.307  -15.258 1.00 21.48 ? 57  LEU A N   1 
ATOM   296  C  CA  . LEU A 1 63  ? -6.389  16.519  -13.838 1.00 21.68 ? 57  LEU A CA  1 
ATOM   297  C  C   . LEU A 1 63  ? -5.105  16.846  -13.082 1.00 22.72 ? 57  LEU A C   1 
ATOM   298  O  O   . LEU A 1 63  ? -5.038  17.846  -12.362 1.00 25.53 ? 57  LEU A O   1 
ATOM   299  C  CB  . LEU A 1 63  ? -7.077  15.297  -13.234 1.00 19.08 ? 57  LEU A CB  1 
ATOM   300  C  CG  . LEU A 1 63  ? -7.271  15.330  -11.717 1.00 16.57 ? 57  LEU A CG  1 
ATOM   301  C  CD1 . LEU A 1 63  ? -8.298  16.386  -11.328 1.00 14.41 ? 57  LEU A CD1 1 
ATOM   302  C  CD2 . LEU A 1 63  ? -7.674  13.955  -11.207 1.00 16.80 ? 57  LEU A CD2 1 
ATOM   303  N  N   . LEU A 1 64  ? -4.080  16.010  -13.210 1.00 22.89 ? 58  LEU A N   1 
ATOM   304  C  CA  . LEU A 1 64  ? -2.861  16.256  -12.445 1.00 25.26 ? 58  LEU A CA  1 
ATOM   305  C  C   . LEU A 1 64  ? -2.194  17.559  -12.872 1.00 29.94 ? 58  LEU A C   1 
ATOM   306  O  O   . LEU A 1 64  ? -1.642  18.293  -12.036 1.00 27.92 ? 58  LEU A O   1 
ATOM   307  C  CB  . LEU A 1 64  ? -1.896  15.085  -12.599 1.00 24.53 ? 58  LEU A CB  1 
ATOM   308  C  CG  . LEU A 1 64  ? -2.348  13.768  -11.977 1.00 26.53 ? 58  LEU A CG  1 
ATOM   309  C  CD1 . LEU A 1 64  ? -1.380  12.658  -12.365 1.00 30.01 ? 58  LEU A CD1 1 
ATOM   310  C  CD2 . LEU A 1 64  ? -2.421  13.898  -10.479 1.00 23.02 ? 58  LEU A CD2 1 
ATOM   311  N  N   . THR A 1 65  ? -2.235  17.857  -14.172 1.00 25.50 ? 59  THR A N   1 
ATOM   312  C  CA  . THR A 1 65  ? -1.622  19.074  -14.700 1.00 30.00 ? 59  THR A CA  1 
ATOM   313  C  C   . THR A 1 65  ? -2.304  20.329  -14.144 1.00 30.02 ? 59  THR A C   1 
ATOM   314  O  O   . THR A 1 65  ? -1.638  21.239  -13.639 1.00 31.51 ? 59  THR A O   1 
ATOM   315  C  CB  . THR A 1 65  ? -1.672  19.017  -16.237 1.00 24.74 ? 59  THR A CB  1 
ATOM   316  O  OG1 . THR A 1 65  ? -0.596  18.192  -16.701 1.00 26.57 ? 59  THR A OG1 1 
ATOM   317  C  CG2 . THR A 1 65  ? -1.564  20.392  -16.866 1.00 30.75 ? 59  THR A CG2 1 
ATOM   318  N  N   . GLU A 1 66  ? -3.638  20.375  -14.198 1.00 30.50 ? 60  GLU A N   1 
ATOM   319  C  CA  . GLU A 1 66  ? -4.377  21.498  -13.626 1.00 30.25 ? 60  GLU A CA  1 
ATOM   320  C  C   . GLU A 1 66  ? -4.124  21.656  -12.128 1.00 31.99 ? 60  GLU A C   1 
ATOM   321  O  O   . GLU A 1 66  ? -4.234  22.765  -11.597 1.00 29.63 ? 60  GLU A O   1 
ATOM   322  C  CB  . GLU A 1 66  ? -5.865  21.311  -13.887 1.00 31.69 ? 60  GLU A CB  1 
ATOM   323  C  CG  . GLU A 1 66  ? -6.209  21.228  -15.360 1.00 34.64 ? 60  GLU A CG  1 
ATOM   324  C  CD  . GLU A 1 66  ? -6.536  22.584  -15.961 1.00 50.06 ? 60  GLU A CD  1 
ATOM   325  O  OE1 . GLU A 1 66  ? -5.901  23.591  -15.564 1.00 52.71 ? 60  GLU A OE1 1 
ATOM   326  O  OE2 . GLU A 1 66  ? -7.437  22.647  -16.827 1.00 55.35 ? 60  GLU A OE2 1 
ATOM   327  N  N   . GLU A 1 67  ? -3.809  20.575  -11.425 1.00 28.74 ? 61  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 67  ? -3.518  20.672  -10.002 1.00 32.52 ? 61  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 67  ? -2.033  20.796  -9.714  1.00 29.54 ? 61  GLU A C   1 
ATOM   330  O  O   . GLU A 1 67  ? -1.654  20.815  -8.543  1.00 32.63 ? 61  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 67  ? -4.085  19.461  -9.236  1.00 29.42 ? 61  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 67  ? -5.603  19.494  -9.049  1.00 29.89 ? 61  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 67  ? -6.095  20.736  -8.304  1.00 33.80 ? 61  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 67  ? -5.568  21.042  -7.210  1.00 35.23 ? 61  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 67  ? -7.010  21.416  -8.827  1.00 34.17 ? 61  GLU A OE2 1 
ATOM   336  N  N   . ARG A 1 68  ? -1.186  20.882  -10.734 1.00 30.45 ? 62  ARG A N   1 
ATOM   337  C  CA  . ARG A 1 68  ? 0.252   21.010  -10.516 1.00 31.03 ? 62  ARG A CA  1 
ATOM   338  C  C   . ARG A 1 68  ? 0.710   19.975  -9.488  1.00 35.39 ? 62  ARG A C   1 
ATOM   339  O  O   . ARG A 1 68  ? 1.270   20.287  -8.436  1.00 41.34 ? 62  ARG A O   1 
ATOM   340  C  CB  . ARG A 1 68  ? 0.596   22.443  -10.087 1.00 36.21 ? 62  ARG A CB  1 
ATOM   341  C  CG  . ARG A 1 68  ? 1.894   22.609  -9.279  1.00 44.56 ? 62  ARG A CG  1 
ATOM   342  C  CD  . ARG A 1 68  ? 2.408   24.056  -9.234  1.00 46.75 ? 62  ARG A CD  1 
ATOM   343  N  NE  . ARG A 1 68  ? 2.316   24.675  -10.549 1.00 47.06 ? 62  ARG A NE  1 
ATOM   344  C  CZ  . ARG A 1 68  ? 3.344   25.244  -11.165 1.00 44.83 ? 62  ARG A CZ  1 
ATOM   345  N  NH1 . ARG A 1 68  ? 4.543   25.285  -10.600 1.00 39.22 ? 62  ARG A NH1 1 
ATOM   346  N  NH2 . ARG A 1 68  ? 3.174   25.748  -12.388 1.00 30.39 ? 62  ARG A NH2 1 
ATOM   347  N  N   . ALA A 1 69  ? 0.419   18.713  -9.790  1.00 34.55 ? 63  ALA A N   1 
ATOM   348  C  CA  . ALA A 1 69  ? 0.683   17.624  -8.859  1.00 30.93 ? 63  ALA A CA  1 
ATOM   349  C  C   . ALA A 1 69  ? 1.398   16.496  -9.584  1.00 30.36 ? 63  ALA A C   1 
ATOM   350  O  O   . ALA A 1 69  ? 1.310   16.370  -10.809 1.00 30.49 ? 63  ALA A O   1 
ATOM   351  C  CB  . ALA A 1 69  ? -0.615  17.098  -8.221  1.00 29.60 ? 63  ALA A CB  1 
ATOM   352  N  N   . GLU A 1 70  ? 2.121   15.686  -8.811  1.00 29.75 ? 64  GLU A N   1 
ATOM   353  C  CA  . GLU A 1 70  ? 2.700   14.426  -9.285  1.00 38.52 ? 64  GLU A CA  1 
ATOM   354  C  C   . GLU A 1 70  ? 3.393   14.614  -10.637 1.00 35.47 ? 64  GLU A C   1 
ATOM   355  O  O   . GLU A 1 70  ? 2.927   14.154  -11.684 1.00 34.60 ? 64  GLU A O   1 
ATOM   356  C  CB  . GLU A 1 70  ? 1.625   13.337  -9.378  1.00 29.66 ? 64  GLU A CB  1 
ATOM   357  C  CG  . GLU A 1 70  ? 0.724   13.250  -8.158  1.00 34.93 ? 64  GLU A CG  1 
ATOM   358  C  CD  . GLU A 1 70  ? 1.371   12.488  -7.009  1.00 39.78 ? 64  GLU A CD  1 
ATOM   359  O  OE1 . GLU A 1 70  ? 2.409   11.816  -7.229  1.00 39.72 ? 64  GLU A OE1 1 
ATOM   360  O  OE2 . GLU A 1 70  ? 0.837   12.561  -5.881  1.00 45.27 ? 64  GLU A OE2 1 
ATOM   361  N  N   . ALA A 1 71  ? 4.524   15.324  -10.579 1.00 32.08 ? 65  ALA A N   1 
ATOM   362  C  CA  . ALA A 1 71  ? 5.257   15.643  -11.802 1.00 36.43 ? 65  ALA A CA  1 
ATOM   363  C  C   . ALA A 1 71  ? 5.801   14.382  -12.459 1.00 34.02 ? 65  ALA A C   1 
ATOM   364  O  O   . ALA A 1 71  ? 5.816   14.268  -13.691 1.00 39.70 ? 65  ALA A O   1 
ATOM   365  C  CB  . ALA A 1 71  ? 6.398   16.618  -11.498 1.00 31.05 ? 65  ALA A CB  1 
ATOM   366  N  N   . ASP A 1 72  ? 6.271   13.434  -11.649 1.00 33.18 ? 66  ASP A N   1 
ATOM   367  C  CA  . ASP A 1 72  ? 6.729   12.157  -12.181 1.00 35.77 ? 66  ASP A CA  1 
ATOM   368  C  C   . ASP A 1 72  ? 5.619   11.489  -12.987 1.00 37.49 ? 66  ASP A C   1 
ATOM   369  O  O   . ASP A 1 72  ? 5.781   11.204  -14.181 1.00 33.02 ? 66  ASP A O   1 
ATOM   370  C  CB  . ASP A 1 72  ? 7.211   11.255  -11.034 1.00 32.31 ? 66  ASP A CB  1 
ATOM   371  C  CG  . ASP A 1 72  ? 8.605   11.653  -10.503 1.00 47.09 ? 66  ASP A CG  1 
ATOM   372  O  OD1 . ASP A 1 72  ? 9.212   12.601  -11.064 1.00 46.59 ? 66  ASP A OD1 1 
ATOM   373  O  OD2 . ASP A 1 72  ? 9.093   11.013  -9.525  1.00 40.52 ? 66  ASP A OD2 1 
ATOM   374  N  N   . ALA A 1 73  ? 4.446   11.324  -12.386 1.00 36.69 ? 67  ALA A N   1 
ATOM   375  C  CA  . ALA A 1 73  ? 3.313   10.681  -13.079 1.00 35.26 ? 67  ALA A CA  1 
ATOM   376  C  C   . ALA A 1 73  ? 2.933   11.473  -14.328 1.00 33.81 ? 67  ALA A C   1 
ATOM   377  O  O   . ALA A 1 73  ? 2.619   10.843  -15.335 1.00 34.04 ? 67  ALA A O   1 
ATOM   378  C  CB  . ALA A 1 73  ? 2.137   10.566  -12.146 1.00 31.13 ? 67  ALA A CB  1 
ATOM   379  N  N   . THR A 1 74  ? 2.961   12.797  -14.248 1.00 28.99 ? 68  THR A N   1 
ATOM   380  C  CA  . THR A 1 74  ? 2.481   13.599  -15.398 1.00 32.39 ? 68  THR A CA  1 
ATOM   381  C  C   . THR A 1 74  ? 3.430   13.397  -16.582 1.00 31.51 ? 68  THR A C   1 
ATOM   382  O  O   . THR A 1 74  ? 2.942   13.411  -17.707 1.00 33.40 ? 68  THR A O   1 
ATOM   383  C  CB  . THR A 1 74  ? 2.246   15.075  -15.038 1.00 35.53 ? 68  THR A CB  1 
ATOM   384  O  OG1 . THR A 1 74  ? 3.255   15.500  -14.126 1.00 43.67 ? 68  THR A OG1 1 
ATOM   385  C  CG2 . THR A 1 74  ? 0.878   15.306  -14.439 1.00 31.79 ? 68  THR A CG2 1 
ATOM   386  N  N   . ALA A 1 75  ? 4.726   13.228  -16.327 1.00 33.37 ? 69  ALA A N   1 
ATOM   387  C  CA  . ALA A 1 75  ? 5.615   13.054  -17.477 1.00 32.83 ? 69  ALA A CA  1 
ATOM   388  C  C   . ALA A 1 75  ? 5.468   11.664  -18.093 1.00 33.93 ? 69  ALA A C   1 
ATOM   389  O  O   . ALA A 1 75  ? 5.474   11.521  -19.325 1.00 35.51 ? 69  ALA A O   1 
ATOM   390  C  CB  . ALA A 1 75  ? 7.064   13.294  -17.057 1.00 33.29 ? 69  ALA A CB  1 
ATOM   391  N  N   . ARG A 1 76  ? 5.360   10.635  -17.247 1.00 29.54 ? 70  ARG A N   1 
ATOM   392  C  CA  . ARG A 1 76  ? 5.047   9.296   -17.729 1.00 27.12 ? 70  ARG A CA  1 
ATOM   393  C  C   . ARG A 1 76  ? 3.759   9.294   -18.546 1.00 32.54 ? 70  ARG A C   1 
ATOM   394  O  O   . ARG A 1 76  ? 3.738   8.830   -19.693 1.00 31.42 ? 70  ARG A O   1 
ATOM   395  C  CB  . ARG A 1 76  ? 4.945   8.344   -16.548 1.00 28.15 ? 70  ARG A CB  1 
ATOM   396  C  CG  . ARG A 1 76  ? 6.293   7.934   -16.032 1.00 28.12 ? 70  ARG A CG  1 
ATOM   397  C  CD  . ARG A 1 76  ? 6.162   6.988   -14.889 1.00 32.31 ? 70  ARG A CD  1 
ATOM   398  N  NE  . ARG A 1 76  ? 5.895   5.636   -15.360 1.00 36.56 ? 70  ARG A NE  1 
ATOM   399  C  CZ  . ARG A 1 76  ? 5.243   4.721   -14.657 1.00 35.97 ? 70  ARG A CZ  1 
ATOM   400  N  NH1 . ARG A 1 76  ? 4.771   4.988   -13.452 1.00 31.78 ? 70  ARG A NH1 1 
ATOM   401  N  NH2 . ARG A 1 76  ? 5.053   3.511   -15.183 1.00 35.26 ? 70  ARG A NH2 1 
ATOM   402  N  N   . LEU A 1 77  ? 2.670   9.825   -17.979 1.00 30.66 ? 71  LEU A N   1 
ATOM   403  C  CA  . LEU A 1 77  ? 1.432   9.927   -18.743 1.00 28.03 ? 71  LEU A CA  1 
ATOM   404  C  C   . LEU A 1 77  ? 1.672   10.603  -20.083 1.00 30.85 ? 71  LEU A C   1 
ATOM   405  O  O   . LEU A 1 77  ? 1.155   10.152  -21.118 1.00 28.80 ? 71  LEU A O   1 
ATOM   406  C  CB  . LEU A 1 77  ? 0.361   10.671  -17.939 1.00 25.32 ? 71  LEU A CB  1 
ATOM   407  C  CG  . LEU A 1 77  ? -0.329  9.825   -16.849 1.00 25.72 ? 71  LEU A CG  1 
ATOM   408  C  CD1 . LEU A 1 77  ? -0.880  10.689  -15.715 1.00 26.78 ? 71  LEU A CD1 1 
ATOM   409  C  CD2 . LEU A 1 77  ? -1.432  8.956   -17.445 1.00 21.67 ? 71  LEU A CD2 1 
ATOM   410  N  N   . THR A 1 78  ? 2.489   11.665  -20.095 1.00 27.45 ? 72  THR A N   1 
ATOM   411  C  CA  . THR A 1 78  ? 2.733   12.397  -21.342 1.00 32.91 ? 72  THR A CA  1 
ATOM   412  C  C   . THR A 1 78  ? 3.499   11.548  -22.358 1.00 29.23 ? 72  THR A C   1 
ATOM   413  O  O   . THR A 1 78  ? 3.196   11.590  -23.555 1.00 31.12 ? 72  THR A O   1 
ATOM   414  C  CB  . THR A 1 78  ? 3.502   13.696  -21.063 1.00 31.55 ? 72  THR A CB  1 
ATOM   415  O  OG1 . THR A 1 78  ? 2.798   14.472  -20.087 1.00 33.62 ? 72  THR A OG1 1 
ATOM   416  C  CG2 . THR A 1 78  ? 3.635   14.511  -22.340 1.00 31.24 ? 72  THR A CG2 1 
ATOM   417  N  N   . ALA A 1 79  ? 4.519   10.806  -21.912 1.00 27.08 ? 73  ALA A N   1 
ATOM   418  C  CA  . ALA A 1 79  ? 5.254   9.945   -22.836 1.00 32.51 ? 73  ALA A CA  1 
ATOM   419  C  C   . ALA A 1 79  ? 4.365   8.827   -23.369 1.00 33.38 ? 73  ALA A C   1 
ATOM   420  O  O   . ALA A 1 79  ? 4.353   8.553   -24.576 1.00 34.84 ? 73  ALA A O   1 
ATOM   421  C  CB  . ALA A 1 79  ? 6.488   9.367   -22.151 1.00 28.03 ? 73  ALA A CB  1 
ATOM   422  N  N   . TYR A 1 80  ? 3.594   8.188   -22.488 1.00 29.28 ? 74  TYR A N   1 
ATOM   423  C  CA  . TYR A 1 80  ? 2.674   7.148   -22.932 1.00 28.55 ? 74  TYR A CA  1 
ATOM   424  C  C   . TYR A 1 80  ? 1.745   7.673   -24.024 1.00 33.38 ? 74  TYR A C   1 
ATOM   425  O  O   . TYR A 1 80  ? 1.544   7.016   -25.053 1.00 34.65 ? 74  TYR A O   1 
ATOM   426  C  CB  . TYR A 1 80  ? 1.870   6.596   -21.746 1.00 29.50 ? 74  TYR A CB  1 
ATOM   427  C  CG  . TYR A 1 80  ? 0.630   5.852   -22.192 1.00 31.96 ? 74  TYR A CG  1 
ATOM   428  C  CD1 . TYR A 1 80  ? 0.687   4.493   -22.506 1.00 28.78 ? 74  TYR A CD1 1 
ATOM   429  C  CD2 . TYR A 1 80  ? -0.586  6.516   -22.346 1.00 25.69 ? 74  TYR A CD2 1 
ATOM   430  C  CE1 . TYR A 1 80  ? -0.437  3.809   -22.940 1.00 29.43 ? 74  TYR A CE1 1 
ATOM   431  C  CE2 . TYR A 1 80  ? -1.709  5.851   -22.774 1.00 25.33 ? 74  TYR A CE2 1 
ATOM   432  C  CZ  . TYR A 1 80  ? -1.634  4.491   -23.068 1.00 30.91 ? 74  TYR A CZ  1 
ATOM   433  O  OH  . TYR A 1 80  ? -2.757  3.819   -23.501 1.00 26.85 ? 74  TYR A OH  1 
ATOM   434  N  N   . LEU A 1 81  ? 1.181   8.870   -23.835 1.00 32.04 ? 75  LEU A N   1 
ATOM   435  C  CA  . LEU A 1 81  ? 0.213   9.348   -24.821 1.00 33.24 ? 75  LEU A CA  1 
ATOM   436  C  C   . LEU A 1 81  ? 0.873   9.569   -26.178 1.00 34.24 ? 75  LEU A C   1 
ATOM   437  O  O   . LEU A 1 81  ? 0.295   9.238   -27.217 1.00 35.29 ? 75  LEU A O   1 
ATOM   438  C  CB  . LEU A 1 81  ? -0.466  10.632  -24.336 1.00 34.73 ? 75  LEU A CB  1 
ATOM   439  C  CG  . LEU A 1 81  ? -1.538  10.493  -23.245 1.00 33.28 ? 75  LEU A CG  1 
ATOM   440  C  CD1 . LEU A 1 81  ? -1.827  11.856  -22.678 1.00 28.09 ? 75  LEU A CD1 1 
ATOM   441  C  CD2 . LEU A 1 81  ? -2.828  9.843   -23.745 1.00 22.86 ? 75  LEU A CD2 1 
ATOM   442  N  N   . ARG A 1 82  ? 2.077   10.140  -26.195 1.00 38.32 ? 76  ARG A N   1 
ATOM   443  C  CA  . ARG A 1 82  ? 2.741   10.395  -27.473 1.00 35.59 ? 76  ARG A CA  1 
ATOM   444  C  C   . ARG A 1 82  ? 3.134   9.085   -28.145 1.00 35.21 ? 76  ARG A C   1 
ATOM   445  O  O   . ARG A 1 82  ? 2.840   8.868   -29.326 1.00 36.51 ? 76  ARG A O   1 
ATOM   446  C  CB  . ARG A 1 82  ? 3.953   11.303  -27.258 1.00 34.55 ? 76  ARG A CB  1 
ATOM   447  C  CG  . ARG A 1 82  ? 3.564   12.795  -27.176 1.00 46.77 ? 76  ARG A CG  1 
ATOM   448  C  CD  . ARG A 1 82  ? 4.735   13.719  -26.805 1.00 46.69 ? 76  ARG A CD  1 
ATOM   449  N  NE  . ARG A 1 82  ? 4.344   15.107  -26.552 1.00 46.00 ? 76  ARG A NE  1 
ATOM   450  C  CZ  . ARG A 1 82  ? 3.489   15.819  -27.286 1.00 47.36 ? 76  ARG A CZ  1 
ATOM   451  N  NH1 . ARG A 1 82  ? 2.902   15.313  -28.361 1.00 48.44 ? 76  ARG A NH1 1 
ATOM   452  N  NH2 . ARG A 1 82  ? 3.227   17.078  -26.938 1.00 41.11 ? 76  ARG A NH2 1 
ATOM   453  N  N   . THR A 1 83  ? 3.760   8.183   -27.388 1.00 33.39 ? 77  THR A N   1 
ATOM   454  C  CA  . THR A 1 83  ? 4.130   6.876   -27.908 1.00 36.96 ? 77  THR A CA  1 
ATOM   455  C  C   . THR A 1 83  ? 2.941   6.171   -28.548 1.00 38.79 ? 77  THR A C   1 
ATOM   456  O  O   . THR A 1 83  ? 3.057   5.589   -29.635 1.00 37.08 ? 77  THR A O   1 
ATOM   457  C  CB  . THR A 1 83  ? 4.683   6.019   -26.777 1.00 39.05 ? 77  THR A CB  1 
ATOM   458  O  OG1 . THR A 1 83  ? 5.954   6.532   -26.363 1.00 40.37 ? 77  THR A OG1 1 
ATOM   459  C  CG2 . THR A 1 83  ? 4.855   4.599   -27.263 1.00 40.85 ? 77  THR A CG2 1 
ATOM   460  N  N   . THR A 1 84  ? 1.784   6.216   -27.880 1.00 38.58 ? 78  THR A N   1 
ATOM   461  C  CA  . THR A 1 84  ? 0.604   5.480   -28.326 1.00 37.04 ? 78  THR A CA  1 
ATOM   462  C  C   . THR A 1 84  ? -0.043  6.135   -29.536 1.00 37.71 ? 78  THR A C   1 
ATOM   463  O  O   . THR A 1 84  ? -0.672  5.448   -30.345 1.00 37.43 ? 78  THR A O   1 
ATOM   464  C  CB  . THR A 1 84  ? -0.402  5.380   -27.167 1.00 35.60 ? 78  THR A CB  1 
ATOM   465  O  OG1 . THR A 1 84  ? 0.251   4.836   -26.014 1.00 31.10 ? 78  THR A OG1 1 
ATOM   466  C  CG2 . THR A 1 84  ? -1.593  4.495   -27.520 1.00 33.43 ? 78  THR A CG2 1 
ATOM   467  N  N   . LEU A 1 85  ? 0.078   7.459   -29.663 1.00 37.58 ? 79  LEU A N   1 
ATOM   468  C  CA  . LEU A 1 85  ? -0.497  8.152   -30.812 1.00 39.96 ? 79  LEU A CA  1 
ATOM   469  C  C   . LEU A 1 85  ? 0.237   7.790   -32.099 1.00 38.26 ? 79  LEU A C   1 
ATOM   470  O  O   . LEU A 1 85  ? -0.400  7.510   -33.123 1.00 41.00 ? 79  LEU A O   1 
ATOM   471  C  CB  . LEU A 1 85  ? -0.471  9.667   -30.580 1.00 35.44 ? 79  LEU A CB  1 
ATOM   472  C  CG  . LEU A 1 85  ? -1.598  10.220  -29.699 1.00 40.98 ? 79  LEU A CG  1 
ATOM   473  C  CD1 . LEU A 1 85  ? -1.541  11.747  -29.591 1.00 41.57 ? 79  LEU A CD1 1 
ATOM   474  C  CD2 . LEU A 1 85  ? -2.951  9.784   -30.242 1.00 39.79 ? 79  LEU A CD2 1 
ATOM   475  N  N   . ARG A 1 86  ? 1.573   7.772   -32.064 1.00 37.18 ? 80  ARG A N   1 
ATOM   476  C  CA  . ARG A 1 86  ? 2.335   7.330   -33.227 1.00 39.89 ? 80  ARG A CA  1 
ATOM   477  C  C   . ARG A 1 86  ? 2.049   5.867   -33.544 1.00 40.83 ? 80  ARG A C   1 
ATOM   478  O  O   . ARG A 1 86  ? 1.598   5.533   -34.643 1.00 49.55 ? 80  ARG A O   1 
ATOM   479  C  CB  . ARG A 1 86  ? 3.837   7.522   -33.002 1.00 42.22 ? 80  ARG A CB  1 
ATOM   480  C  CG  . ARG A 1 86  ? 4.244   8.723   -32.178 1.00 46.41 ? 80  ARG A CG  1 
ATOM   481  C  CD  . ARG A 1 86  ? 5.308   8.315   -31.156 1.00 47.95 ? 80  ARG A CD  1 
ATOM   482  N  NE  . ARG A 1 86  ? 5.971   9.458   -30.533 1.00 51.19 ? 80  ARG A NE  1 
ATOM   483  C  CZ  . ARG A 1 86  ? 6.819   9.371   -29.513 1.00 45.24 ? 80  ARG A CZ  1 
ATOM   484  N  NH1 . ARG A 1 86  ? 7.109   8.205   -28.950 1.00 43.86 ? 80  ARG A NH1 1 
ATOM   485  N  NH2 . ARG A 1 86  ? 7.392   10.477  -29.047 1.00 42.91 ? 80  ARG A NH2 1 
ATOM   486  N  N   . THR A 1 87  ? 2.282   4.977   -32.575 1.00 39.43 ? 81  THR A N   1 
ATOM   487  C  CA  . THR A 1 87  ? 2.422   3.551   -32.864 1.00 42.57 ? 81  THR A CA  1 
ATOM   488  C  C   . THR A 1 87  ? 1.109   2.765   -32.852 1.00 44.32 ? 81  THR A C   1 
ATOM   489  O  O   . THR A 1 87  ? 0.942   1.851   -33.665 1.00 48.42 ? 81  THR A O   1 
ATOM   490  C  CB  . THR A 1 87  ? 3.407   2.920   -31.877 1.00 40.82 ? 81  THR A CB  1 
ATOM   491  O  OG1 . THR A 1 87  ? 2.795   2.812   -30.588 1.00 44.93 ? 81  THR A OG1 1 
ATOM   492  C  CG2 . THR A 1 87  ? 4.663   3.774   -31.759 1.00 38.34 ? 81  THR A CG2 1 
ATOM   493  N  N   . ALA A 1 88  ? 0.174   3.053   -31.947 1.00 41.79 ? 82  ALA A N   1 
ATOM   494  C  CA  . ALA A 1 88  ? -1.072  2.285   -31.856 1.00 42.46 ? 82  ALA A CA  1 
ATOM   495  C  C   . ALA A 1 88  ? -2.239  3.221   -31.575 1.00 41.09 ? 82  ALA A C   1 
ATOM   496  O  O   . ALA A 1 88  ? -2.996  3.035   -30.618 1.00 40.68 ? 82  ALA A O   1 
ATOM   497  C  CB  . ALA A 1 88  ? -0.969  1.193   -30.791 1.00 45.37 ? 82  ALA A CB  1 
ATOM   498  N  N   . PRO A 1 89  ? -2.437  4.222   -32.424 1.00 41.13 ? 83  PRO A N   1 
ATOM   499  C  CA  . PRO A 1 89  ? -3.441  5.246   -32.127 1.00 39.76 ? 83  PRO A CA  1 
ATOM   500  C  C   . PRO A 1 89  ? -4.838  4.653   -32.148 1.00 38.70 ? 83  PRO A C   1 
ATOM   501  O  O   . PRO A 1 89  ? -5.162  3.831   -33.020 1.00 39.78 ? 83  PRO A O   1 
ATOM   502  C  CB  . PRO A 1 89  ? -3.242  6.292   -33.238 1.00 35.03 ? 83  PRO A CB  1 
ATOM   503  C  CG  . PRO A 1 89  ? -2.368  5.654   -34.272 1.00 44.82 ? 83  PRO A CG  1 
ATOM   504  C  CD  . PRO A 1 89  ? -1.875  4.323   -33.782 1.00 41.56 ? 83  PRO A CD  1 
ATOM   505  N  N   . PRO A 1 90  ? -5.697  5.043   -31.180 1.00 36.49 ? 84  PRO A N   1 
ATOM   506  C  CA  . PRO A 1 90  ? -7.040  4.454   -31.074 1.00 35.28 ? 84  PRO A CA  1 
ATOM   507  C  C   . PRO A 1 90  ? -8.064  5.136   -31.971 1.00 29.19 ? 84  PRO A C   1 
ATOM   508  O  O   . PRO A 1 90  ? -7.688  5.776   -32.951 1.00 28.98 ? 84  PRO A O   1 
ATOM   509  C  CB  . PRO A 1 90  ? -7.376  4.658   -29.595 1.00 34.91 ? 84  PRO A CB  1 
ATOM   510  C  CG  . PRO A 1 90  ? -6.701  5.986   -29.290 1.00 33.37 ? 84  PRO A CG  1 
ATOM   511  C  CD  . PRO A 1 90  ? -5.437  6.022   -30.110 1.00 31.37 ? 84  PRO A CD  1 
ATOM   512  N  N   . ASP A 1 91  ? -9.353  5.008   -31.655 1.00 28.26 ? 85  ASP A N   1 
ATOM   513  C  CA  . ASP A 1 91  ? -10.429 5.639   -32.418 1.00 28.44 ? 85  ASP A CA  1 
ATOM   514  C  C   . ASP A 1 91  ? -10.261 7.165   -32.465 1.00 32.64 ? 85  ASP A C   1 
ATOM   515  O  O   . ASP A 1 91  ? -9.477  7.736   -31.694 1.00 29.41 ? 85  ASP A O   1 
ATOM   516  C  CB  . ASP A 1 91  ? -11.791 5.263   -31.822 1.00 24.18 ? 85  ASP A CB  1 
ATOM   517  C  CG  . ASP A 1 91  ? -11.964 5.766   -30.372 1.00 34.99 ? 85  ASP A CG  1 
ATOM   518  O  OD1 . ASP A 1 91  ? -12.321 6.954   -30.185 1.00 33.16 ? 85  ASP A OD1 1 
ATOM   519  O  OD2 . ASP A 1 91  ? -11.745 4.978   -29.417 1.00 34.82 ? 85  ASP A OD2 1 
ATOM   520  N  N   . PRO A 1 92  ? -10.963 7.861   -33.365 1.00 31.03 ? 86  PRO A N   1 
ATOM   521  C  CA  . PRO A 1 92  ? -10.711 9.306   -33.510 1.00 32.59 ? 86  PRO A CA  1 
ATOM   522  C  C   . PRO A 1 92  ? -11.135 10.135  -32.302 1.00 31.98 ? 86  PRO A C   1 
ATOM   523  O  O   . PRO A 1 92  ? -10.490 11.153  -32.009 1.00 32.03 ? 86  PRO A O   1 
ATOM   524  C  CB  . PRO A 1 92  ? -11.518 9.686   -34.766 1.00 32.33 ? 86  PRO A CB  1 
ATOM   525  C  CG  . PRO A 1 92  ? -11.693 8.396   -35.525 1.00 34.17 ? 86  PRO A CG  1 
ATOM   526  C  CD  . PRO A 1 92  ? -11.800 7.327   -34.453 1.00 34.34 ? 86  PRO A CD  1 
ATOM   527  N  N   . PHE A 1 93  ? -12.208 9.757   -31.602 1.00 28.06 ? 87  PHE A N   1 
ATOM   528  C  CA  . PHE A 1 93  ? -12.584 10.502  -30.407 1.00 27.33 ? 87  PHE A CA  1 
ATOM   529  C  C   . PHE A 1 93  ? -11.442 10.512  -29.397 1.00 28.02 ? 87  PHE A C   1 
ATOM   530  O  O   . PHE A 1 93  ? -11.073 11.569  -28.871 1.00 30.05 ? 87  PHE A O   1 
ATOM   531  C  CB  . PHE A 1 93  ? -13.861 9.928   -29.788 1.00 24.60 ? 87  PHE A CB  1 
ATOM   532  C  CG  . PHE A 1 93  ? -14.192 10.522  -28.422 1.00 32.69 ? 87  PHE A CG  1 
ATOM   533  C  CD1 . PHE A 1 93  ? -14.757 11.781  -28.319 1.00 26.06 ? 87  PHE A CD1 1 
ATOM   534  C  CD2 . PHE A 1 93  ? -13.909 9.821   -27.250 1.00 26.96 ? 87  PHE A CD2 1 
ATOM   535  C  CE1 . PHE A 1 93  ? -15.060 12.318  -27.085 1.00 29.83 ? 87  PHE A CE1 1 
ATOM   536  C  CE2 . PHE A 1 93  ? -14.202 10.356  -26.011 1.00 30.28 ? 87  PHE A CE2 1 
ATOM   537  C  CZ  . PHE A 1 93  ? -14.778 11.607  -25.926 1.00 31.02 ? 87  PHE A CZ  1 
ATOM   538  N  N   . GLN A 1 94  ? -10.856 9.344   -29.124 1.00 25.74 ? 88  GLN A N   1 
ATOM   539  C  CA  . GLN A 1 94  ? -9.787  9.283   -28.129 1.00 27.90 ? 88  GLN A CA  1 
ATOM   540  C  C   . GLN A 1 94  ? -8.531  10.018  -28.600 1.00 29.65 ? 88  GLN A C   1 
ATOM   541  O  O   . GLN A 1 94  ? -7.824  10.627  -27.787 1.00 26.80 ? 88  GLN A O   1 
ATOM   542  C  CB  . GLN A 1 94  ? -9.457  7.833   -27.798 1.00 22.12 ? 88  GLN A CB  1 
ATOM   543  C  CG  . GLN A 1 94  ? -10.492 7.098   -26.992 1.00 25.12 ? 88  GLN A CG  1 
ATOM   544  C  CD  . GLN A 1 94  ? -9.907  5.831   -26.358 1.00 27.74 ? 88  GLN A CD  1 
ATOM   545  O  OE1 . GLN A 1 94  ? -9.141  5.903   -25.394 1.00 26.14 ? 88  GLN A OE1 1 
ATOM   546  N  NE2 . GLN A 1 94  ? -10.241 4.671   -26.924 1.00 25.64 ? 88  GLN A NE2 1 
ATOM   547  N  N   . CYS A 1 95  ? -8.218  9.961   -29.901 1.00 23.64 ? 89  CYS A N   1 
ATOM   548  C  CA  . CYS A 1 95  ? -7.086  10.739  -30.403 1.00 28.88 ? 89  CYS A CA  1 
ATOM   549  C  C   . CYS A 1 95  ? -7.321  12.230  -30.201 1.00 32.22 ? 89  CYS A C   1 
ATOM   550  O  O   . CYS A 1 95  ? -6.419  12.964  -29.784 1.00 29.20 ? 89  CYS A O   1 
ATOM   551  C  CB  . CYS A 1 95  ? -6.847  10.456  -31.887 1.00 33.17 ? 89  CYS A CB  1 
ATOM   552  S  SG  . CYS A 1 95  ? -6.291  8.780   -32.262 1.00 40.64 ? 89  CYS A SG  1 
ATOM   553  N  N   . ALA A 1 96  ? -8.529  12.700  -30.528 1.00 29.42 ? 90  ALA A N   1 
ATOM   554  C  CA  . ALA A 1 96  ? -8.835  14.112  -30.359 1.00 30.11 ? 90  ALA A CA  1 
ATOM   555  C  C   . ALA A 1 96  ? -8.817  14.507  -28.889 1.00 31.59 ? 90  ALA A C   1 
ATOM   556  O  O   . ALA A 1 96  ? -8.439  15.638  -28.561 1.00 31.79 ? 90  ALA A O   1 
ATOM   557  C  CB  . ALA A 1 96  ? -10.188 14.435  -30.989 1.00 30.53 ? 90  ALA A CB  1 
ATOM   558  N  N   . VAL A 1 97  ? -9.211  13.595  -27.989 1.00 29.23 ? 91  VAL A N   1 
ATOM   559  C  CA  . VAL A 1 97  ? -9.077  13.865  -26.557 1.00 29.35 ? 91  VAL A CA  1 
ATOM   560  C  C   . VAL A 1 97  ? -7.609  14.017  -26.184 1.00 25.01 ? 91  VAL A C   1 
ATOM   561  O  O   . VAL A 1 97  ? -7.221  14.950  -25.471 1.00 26.90 ? 91  VAL A O   1 
ATOM   562  C  CB  . VAL A 1 97  ? -9.746  12.756  -25.722 1.00 27.97 ? 91  VAL A CB  1 
ATOM   563  C  CG1 . VAL A 1 97  ? -9.082  12.681  -24.344 1.00 29.61 ? 91  VAL A CG1 1 
ATOM   564  C  CG2 . VAL A 1 97  ? -11.224 13.015  -25.575 1.00 27.52 ? 91  VAL A CG2 1 
ATOM   565  N  N   . ALA A 1 98  ? -6.771  13.082  -26.635 1.00 27.76 ? 92  ALA A N   1 
ATOM   566  C  CA  . ALA A 1 98  ? -5.355  13.147  -26.290 1.00 26.92 ? 92  ALA A CA  1 
ATOM   567  C  C   . ALA A 1 98  ? -4.710  14.397  -26.870 1.00 28.33 ? 92  ALA A C   1 
ATOM   568  O  O   . ALA A 1 98  ? -3.920  15.064  -26.200 1.00 28.88 ? 92  ALA A O   1 
ATOM   569  C  CB  . ALA A 1 98  ? -4.633  11.891  -26.775 1.00 27.82 ? 92  ALA A CB  1 
ATOM   570  N  N   . ARG A 1 99  ? -5.045  14.732  -28.114 1.00 27.85 ? 93  ARG A N   1 
ATOM   571  C  CA  . ARG A 1 99  ? -4.485  15.922  -28.743 1.00 35.04 ? 93  ARG A CA  1 
ATOM   572  C  C   . ARG A 1 99  ? -4.886  17.184  -27.988 1.00 31.96 ? 93  ARG A C   1 
ATOM   573  O  O   . ARG A 1 99  ? -4.069  18.096  -27.802 1.00 31.55 ? 93  ARG A O   1 
ATOM   574  C  CB  . ARG A 1 99  ? -4.929  15.988  -30.210 1.00 33.60 ? 93  ARG A CB  1 
ATOM   575  C  CG  . ARG A 1 99  ? -3.852  15.460  -31.164 1.00 36.58 ? 93  ARG A CG  1 
ATOM   576  C  CD  . ARG A 1 99  ? -4.415  14.825  -32.451 1.00 45.30 ? 93  ARG A CD  1 
ATOM   577  N  NE  . ARG A 1 99  ? -5.721  15.347  -32.845 1.00 47.03 ? 93  ARG A NE  1 
ATOM   578  C  CZ  . ARG A 1 99  ? -6.675  14.619  -33.414 1.00 44.33 ? 93  ARG A CZ  1 
ATOM   579  N  NH1 . ARG A 1 99  ? -6.497  13.336  -33.688 1.00 39.58 ? 93  ARG A NH1 1 
ATOM   580  N  NH2 . ARG A 1 99  ? -7.836  15.193  -33.724 1.00 43.74 ? 93  ARG A NH2 1 
ATOM   581  N  N   . ALA A 1 100 ? -6.131  17.242  -27.517 1.00 28.42 ? 94  ALA A N   1 
ATOM   582  C  CA  . ALA A 1 100 ? -6.564  18.394  -26.734 1.00 32.61 ? 94  ALA A CA  1 
ATOM   583  C  C   . ALA A 1 100 ? -5.739  18.535  -25.455 1.00 32.18 ? 94  ALA A C   1 
ATOM   584  O  O   . ALA A 1 100 ? -5.373  19.650  -25.066 1.00 32.75 ? 94  ALA A O   1 
ATOM   585  C  CB  . ALA A 1 100 ? -8.057  18.279  -26.422 1.00 27.94 ? 94  ALA A CB  1 
ATOM   586  N  N   . VAL A 1 101 ? -5.404  17.419  -24.803 1.00 30.46 ? 95  VAL A N   1 
ATOM   587  C  CA  . VAL A 1 101 ? -4.683  17.527  -23.535 1.00 28.41 ? 95  VAL A CA  1 
ATOM   588  C  C   . VAL A 1 101 ? -3.200  17.796  -23.771 1.00 31.87 ? 95  VAL A C   1 
ATOM   589  O  O   . VAL A 1 101 ? -2.558  18.498  -22.983 1.00 34.23 ? 95  VAL A O   1 
ATOM   590  C  CB  . VAL A 1 101 ? -4.889  16.268  -22.674 1.00 26.97 ? 95  VAL A CB  1 
ATOM   591  C  CG1 . VAL A 1 101 ? -3.985  16.344  -21.462 1.00 29.07 ? 95  VAL A CG1 1 
ATOM   592  C  CG2 . VAL A 1 101 ? -6.345  16.131  -22.249 1.00 27.86 ? 95  VAL A CG2 1 
ATOM   593  N  N   . LEU A 1 102 ? -2.626  17.225  -24.838 1.00 31.90 ? 96  LEU A N   1 
ATOM   594  C  CA  . LEU A 1 102 ? -1.209  17.436  -25.135 1.00 35.86 ? 96  LEU A CA  1 
ATOM   595  C  C   . LEU A 1 102 ? -0.934  18.847  -25.647 1.00 34.20 ? 96  LEU A C   1 
ATOM   596  O  O   . LEU A 1 102 ? 0.217   19.290  -25.613 1.00 39.35 ? 96  LEU A O   1 
ATOM   597  C  CB  . LEU A 1 102 ? -0.715  16.400  -26.159 1.00 29.63 ? 96  LEU A CB  1 
ATOM   598  C  CG  . LEU A 1 102 ? -0.662  14.916  -25.749 1.00 29.32 ? 96  LEU A CG  1 
ATOM   599  C  CD1 . LEU A 1 102 ? -0.488  14.015  -26.981 1.00 32.93 ? 96  LEU A CD1 1 
ATOM   600  C  CD2 . LEU A 1 102 ? 0.433   14.633  -24.730 1.00 24.66 ? 96  LEU A CD2 1 
ATOM   601  N  N   . GLY A 1 103 ? -1.957  19.562  -26.107 1.00 40.77 ? 97  GLY A N   1 
ATOM   602  C  CA  . GLY A 1 103 ? -1.814  20.959  -26.491 1.00 44.76 ? 97  GLY A CA  1 
ATOM   603  C  C   . GLY A 1 103 ? -1.891  21.935  -25.324 1.00 52.29 ? 97  GLY A C   1 
ATOM   604  O  O   . GLY A 1 103 ? -2.879  21.984  -24.578 1.00 53.09 ? 97  GLY A O   1 
ATOM   605  N  N   . GLY A 1 130 ? -24.012 6.842   -37.158 1.00 55.73 ? 124 GLY A N   1 
ATOM   606  C  CA  . GLY A 1 130 ? -23.221 5.626   -37.221 1.00 61.01 ? 124 GLY A CA  1 
ATOM   607  C  C   . GLY A 1 130 ? -23.483 4.663   -36.071 1.00 68.10 ? 124 GLY A C   1 
ATOM   608  O  O   . GLY A 1 130 ? -23.719 3.465   -36.280 1.00 62.19 ? 124 GLY A O   1 
ATOM   609  N  N   . PHE A 1 131 ? -23.437 5.180   -34.844 1.00 63.91 ? 125 PHE A N   1 
ATOM   610  C  CA  . PHE A 1 131 ? -23.696 4.355   -33.668 1.00 58.84 ? 125 PHE A CA  1 
ATOM   611  C  C   . PHE A 1 131 ? -25.149 3.897   -33.690 1.00 60.95 ? 125 PHE A C   1 
ATOM   612  O  O   . PHE A 1 131 ? -26.065 4.682   -33.415 1.00 59.80 ? 125 PHE A O   1 
ATOM   613  C  CB  . PHE A 1 131 ? -23.378 5.120   -32.387 1.00 58.30 ? 125 PHE A CB  1 
ATOM   614  C  CG  . PHE A 1 131 ? -23.225 4.234   -31.180 1.00 48.43 ? 125 PHE A CG  1 
ATOM   615  C  CD1 . PHE A 1 131 ? -22.756 2.937   -31.315 1.00 46.44 ? 125 PHE A CD1 1 
ATOM   616  C  CD2 . PHE A 1 131 ? -23.573 4.689   -29.920 1.00 43.61 ? 125 PHE A CD2 1 
ATOM   617  C  CE1 . PHE A 1 131 ? -22.620 2.108   -30.213 1.00 44.53 ? 125 PHE A CE1 1 
ATOM   618  C  CE2 . PHE A 1 131 ? -23.437 3.869   -28.813 1.00 45.77 ? 125 PHE A CE2 1 
ATOM   619  C  CZ  . PHE A 1 131 ? -22.966 2.570   -28.962 1.00 39.62 ? 125 PHE A CZ  1 
ATOM   620  N  N   . ASP A 1 132 ? -25.360 2.623   -34.026 1.00 65.45 ? 126 ASP A N   1 
ATOM   621  C  CA  . ASP A 1 132 ? -26.697 2.025   -34.100 1.00 70.16 ? 126 ASP A CA  1 
ATOM   622  C  C   . ASP A 1 132 ? -27.059 1.457   -32.728 1.00 64.74 ? 126 ASP A C   1 
ATOM   623  O  O   . ASP A 1 132 ? -26.977 0.250   -32.473 1.00 69.61 ? 126 ASP A O   1 
ATOM   624  C  CB  . ASP A 1 132 ? -26.737 0.947   -35.180 1.00 63.91 ? 126 ASP A CB  1 
ATOM   625  C  CG  . ASP A 1 132 ? -28.054 0.915   -35.937 1.00 75.19 ? 126 ASP A CG  1 
ATOM   626  O  OD1 . ASP A 1 132 ? -28.478 1.970   -36.467 1.00 77.47 ? 126 ASP A OD1 1 
ATOM   627  O  OD2 . ASP A 1 132 ? -28.670 -0.175  -35.996 1.00 79.82 ? 126 ASP A OD2 1 
ATOM   628  N  N   . HIS A 1 133 ? -27.477 2.346   -31.829 1.00 59.42 ? 127 HIS A N   1 
ATOM   629  C  CA  . HIS A 1 133 ? -27.748 1.921   -30.463 1.00 51.97 ? 127 HIS A CA  1 
ATOM   630  C  C   . HIS A 1 133 ? -28.669 2.925   -29.784 1.00 51.78 ? 127 HIS A C   1 
ATOM   631  O  O   . HIS A 1 133 ? -28.642 4.120   -30.091 1.00 45.49 ? 127 HIS A O   1 
ATOM   632  C  CB  . HIS A 1 133 ? -26.447 1.761   -29.668 1.00 51.58 ? 127 HIS A CB  1 
ATOM   633  C  CG  . HIS A 1 133 ? -26.559 0.800   -28.526 1.00 56.87 ? 127 HIS A CG  1 
ATOM   634  N  ND1 . HIS A 1 133 ? -26.678 -0.564  -28.711 1.00 51.29 ? 127 HIS A ND1 1 
ATOM   635  C  CD2 . HIS A 1 133 ? -26.598 1.007   -27.187 1.00 53.46 ? 127 HIS A CD2 1 
ATOM   636  C  CE1 . HIS A 1 133 ? -26.774 -1.155  -27.532 1.00 55.72 ? 127 HIS A CE1 1 
ATOM   637  N  NE2 . HIS A 1 133 ? -26.727 -0.226  -26.591 1.00 56.47 ? 127 HIS A NE2 1 
ATOM   638  N  N   . PHE A 1 134 ? -29.479 2.418   -28.842 1.00 54.36 ? 128 PHE A N   1 
ATOM   639  C  CA  . PHE A 1 134 ? -30.418 3.264   -28.109 1.00 50.98 ? 128 PHE A CA  1 
ATOM   640  C  C   . PHE A 1 134 ? -29.714 4.286   -27.215 1.00 53.32 ? 128 PHE A C   1 
ATOM   641  O  O   . PHE A 1 134 ? -30.301 5.328   -26.898 1.00 53.32 ? 128 PHE A O   1 
ATOM   642  C  CB  . PHE A 1 134 ? -31.379 2.391   -27.284 1.00 52.45 ? 128 PHE A CB  1 
ATOM   643  C  CG  . PHE A 1 134 ? -30.759 1.767   -26.047 1.00 54.26 ? 128 PHE A CG  1 
ATOM   644  C  CD1 . PHE A 1 134 ? -30.766 2.444   -24.831 1.00 50.67 ? 128 PHE A CD1 1 
ATOM   645  C  CD2 . PHE A 1 134 ? -30.205 0.494   -26.092 1.00 50.72 ? 128 PHE A CD2 1 
ATOM   646  C  CE1 . PHE A 1 134 ? -30.211 1.885   -23.688 1.00 42.41 ? 128 PHE A CE1 1 
ATOM   647  C  CE2 . PHE A 1 134 ? -29.650 -0.078  -24.943 1.00 54.80 ? 128 PHE A CE2 1 
ATOM   648  C  CZ  . PHE A 1 134 ? -29.654 0.624   -23.741 1.00 47.22 ? 128 PHE A CZ  1 
ATOM   649  N  N   . THR A 1 135 ? -28.444 4.062   -26.879 1.00 50.52 ? 129 THR A N   1 
ATOM   650  C  CA  . THR A 1 135 ? -27.662 4.989   -26.010 1.00 51.15 ? 129 THR A CA  1 
ATOM   651  C  C   . THR A 1 135 ? -27.218 6.241   -26.777 1.00 51.50 ? 129 THR A C   1 
ATOM   652  O  O   . THR A 1 135 ? -26.919 7.245   -26.124 1.00 47.35 ? 129 THR A O   1 
ATOM   653  C  CB  . THR A 1 135 ? -26.421 4.293   -25.437 1.00 47.12 ? 129 THR A CB  1 
ATOM   654  O  OG1 . THR A 1 135 ? -25.921 5.091   -24.366 1.00 54.67 ? 129 THR A OG1 1 
ATOM   655  C  CG2 . THR A 1 135 ? -25.337 4.080   -26.468 1.00 41.87 ? 129 THR A CG2 1 
ATOM   656  N  N   . ALA A 1 136 ? -27.129 6.152   -28.105 1.00 50.77 ? 130 ALA A N   1 
ATOM   657  C  CA  . ALA A 1 136 ? -26.700 7.302   -28.925 1.00 51.45 ? 130 ALA A CA  1 
ATOM   658  C  C   . ALA A 1 136 ? -27.466 8.550   -28.472 1.00 50.54 ? 130 ALA A C   1 
ATOM   659  O  O   . ALA A 1 136 ? -28.590 8.403   -27.970 1.00 56.76 ? 130 ALA A O   1 
ATOM   660  C  CB  . ALA A 1 136 ? -26.947 7.011   -30.380 1.00 48.70 ? 130 ALA A CB  1 
ATOM   661  N  N   . GLY A 1 137 ? -26.892 9.730   -28.667 1.00 40.24 ? 131 GLY A N   1 
ATOM   662  C  CA  . GLY A 1 137 ? -27.574 10.940  -28.166 1.00 46.79 ? 131 GLY A CA  1 
ATOM   663  C  C   . GLY A 1 137 ? -27.049 11.286  -26.797 1.00 42.11 ? 131 GLY A C   1 
ATOM   664  O  O   . GLY A 1 137 ? -26.425 12.347  -26.662 1.00 36.42 ? 131 GLY A O   1 
ATOM   665  N  N   . ARG A 1 138 ? -27.301 10.417  -25.818 1.00 39.66 ? 132 ARG A N   1 
ATOM   666  C  CA  . ARG A 1 138 ? -26.663 10.619  -24.501 1.00 39.93 ? 132 ARG A CA  1 
ATOM   667  C  C   . ARG A 1 138 ? -25.149 10.600  -24.735 1.00 35.97 ? 132 ARG A C   1 
ATOM   668  O  O   . ARG A 1 138 ? -24.454 11.437  -24.156 1.00 32.41 ? 132 ARG A O   1 
ATOM   669  C  CB  . ARG A 1 138 ? -27.086 9.512   -23.533 1.00 38.33 ? 132 ARG A CB  1 
ATOM   670  C  CG  . ARG A 1 138 ? -26.103 9.257   -22.400 1.00 43.46 ? 132 ARG A CG  1 
ATOM   671  C  CD  . ARG A 1 138 ? -26.734 8.469   -21.270 1.00 45.05 ? 132 ARG A CD  1 
ATOM   672  N  NE  . ARG A 1 138 ? -26.542 7.032   -21.395 1.00 49.72 ? 132 ARG A NE  1 
ATOM   673  C  CZ  . ARG A 1 138 ? -25.368 6.425   -21.279 1.00 50.71 ? 132 ARG A CZ  1 
ATOM   674  N  NH1 . ARG A 1 138 ? -24.282 7.136   -21.041 1.00 49.67 ? 132 ARG A NH1 1 
ATOM   675  N  NH2 . ARG A 1 138 ? -25.284 5.113   -21.402 1.00 45.89 ? 132 ARG A NH2 1 
ATOM   676  N  N   . LYS A 1 139 ? -24.677 9.676   -25.575 1.00 35.53 ? 133 LYS A N   1 
ATOM   677  C  CA  . LYS A 1 139 ? -23.224 9.563   -25.868 1.00 35.74 ? 133 LYS A CA  1 
ATOM   678  C  C   . LYS A 1 139 ? -22.756 10.782  -26.666 1.00 29.87 ? 133 LYS A C   1 
ATOM   679  O  O   . LYS A 1 139 ? -21.673 11.265  -26.376 1.00 32.32 ? 133 LYS A O   1 
ATOM   680  C  CB  . LYS A 1 139 ? -22.906 8.238   -26.563 1.00 37.81 ? 133 LYS A CB  1 
ATOM   681  C  CG  . LYS A 1 139 ? -23.639 7.026   -26.010 1.00 42.67 ? 133 LYS A CG  1 
ATOM   682  C  CD  . LYS A 1 139 ? -22.747 5.826   -25.832 1.00 44.41 ? 133 LYS A CD  1 
ATOM   683  C  CE  . LYS A 1 139 ? -22.924 5.131   -24.500 1.00 37.68 ? 133 LYS A CE  1 
ATOM   684  N  NZ  . LYS A 1 139 ? -22.466 5.985   -23.381 1.00 44.61 ? 133 LYS A NZ  1 
ATOM   685  N  N   . ARG A 1 140 ? -23.556 11.263  -27.615 1.00 31.94 ? 134 ARG A N   1 
ATOM   686  C  CA  . ARG A 1 140 ? -23.129 12.482  -28.296 1.00 34.71 ? 134 ARG A CA  1 
ATOM   687  C  C   . ARG A 1 140 ? -22.916 13.610  -27.296 1.00 28.65 ? 134 ARG A C   1 
ATOM   688  O  O   . ARG A 1 140 ? -21.909 14.329  -27.363 1.00 25.85 ? 134 ARG A O   1 
ATOM   689  C  CB  . ARG A 1 140 ? -24.146 12.891  -29.362 1.00 38.63 ? 134 ARG A CB  1 
ATOM   690  C  CG  . ARG A 1 140 ? -23.552 13.743  -30.494 1.00 36.86 ? 134 ARG A CG  1 
ATOM   691  C  CD  . ARG A 1 140 ? -24.319 13.540  -31.809 1.00 44.55 ? 134 ARG A CD  1 
ATOM   692  N  NE  . ARG A 1 140 ? -23.427 13.073  -32.870 1.00 59.08 ? 134 ARG A NE  1 
ATOM   693  C  CZ  . ARG A 1 140 ? -23.736 12.147  -33.771 1.00 59.32 ? 134 ARG A CZ  1 
ATOM   694  N  NH1 . ARG A 1 140 ? -24.936 11.588  -33.807 1.00 62.41 ? 134 ARG A NH1 1 
ATOM   695  N  NH2 . ARG A 1 140 ? -22.814 11.766  -34.654 1.00 52.02 ? 134 ARG A NH2 1 
ATOM   696  N  N   . LEU A 1 141 ? -23.849 13.759  -26.343 1.00 30.58 ? 135 LEU A N   1 
ATOM   697  C  CA  . LEU A 1 141 ? -23.740 14.808  -25.331 1.00 30.02 ? 135 LEU A CA  1 
ATOM   698  C  C   . LEU A 1 141 ? -22.521 14.579  -24.452 1.00 28.18 ? 135 LEU A C   1 
ATOM   699  O  O   . LEU A 1 141 ? -21.697 15.481  -24.259 1.00 25.93 ? 135 LEU A O   1 
ATOM   700  C  CB  . LEU A 1 141 ? -25.017 14.854  -24.483 1.00 29.53 ? 135 LEU A CB  1 
ATOM   701  C  CG  . LEU A 1 141 ? -25.068 15.855  -23.315 1.00 30.69 ? 135 LEU A CG  1 
ATOM   702  C  CD1 . LEU A 1 141 ? -25.184 17.273  -23.821 1.00 30.11 ? 135 LEU A CD1 1 
ATOM   703  C  CD2 . LEU A 1 141 ? -26.184 15.548  -22.300 1.00 29.97 ? 135 LEU A CD2 1 
ATOM   704  N  N   . MET A 1 142 ? -22.383 13.353  -23.935 1.00 27.97 ? 136 MET A N   1 
ATOM   705  C  CA  . MET A 1 142 ? -21.245 12.997  -23.098 1.00 26.96 ? 136 MET A CA  1 
ATOM   706  C  C   . MET A 1 142 ? -19.923 13.303  -23.799 1.00 25.99 ? 136 MET A C   1 
ATOM   707  O  O   . MET A 1 142 ? -19.066 14.007  -23.253 1.00 23.50 ? 136 MET A O   1 
ATOM   708  C  CB  . MET A 1 142 ? -21.357 11.517  -22.715 1.00 30.03 ? 136 MET A CB  1 
ATOM   709  C  CG  . MET A 1 142 ? -20.068 10.832  -22.242 1.00 33.76 ? 136 MET A CG  1 
ATOM   710  S  SD  . MET A 1 142 ? -20.418 9.127   -21.724 1.00 61.62 ? 136 MET A SD  1 
ATOM   711  C  CE  . MET A 1 142 ? -22.113 9.292   -21.164 1.00 32.31 ? 136 MET A CE  1 
ATOM   712  N  N   . PHE A 1 143 ? -19.759 12.812  -25.031 1.00 25.77 ? 137 PHE A N   1 
ATOM   713  C  CA  . PHE A 1 143 ? -18.472 12.918  -25.714 1.00 23.89 ? 137 PHE A CA  1 
ATOM   714  C  C   . PHE A 1 143 ? -18.172 14.356  -26.134 1.00 26.21 ? 137 PHE A C   1 
ATOM   715  O  O   . PHE A 1 143 ? -17.015 14.794  -26.089 1.00 23.95 ? 137 PHE A O   1 
ATOM   716  C  CB  . PHE A 1 143 ? -18.443 11.972  -26.922 1.00 25.21 ? 137 PHE A CB  1 
ATOM   717  C  CG  . PHE A 1 143 ? -18.306 10.497  -26.554 1.00 33.97 ? 137 PHE A CG  1 
ATOM   718  C  CD1 . PHE A 1 143 ? -17.948 10.112  -25.270 1.00 29.73 ? 137 PHE A CD1 1 
ATOM   719  C  CD2 . PHE A 1 143 ? -18.514 9.503   -27.500 1.00 37.20 ? 137 PHE A CD2 1 
ATOM   720  C  CE1 . PHE A 1 143 ? -17.813 8.766   -24.936 1.00 36.07 ? 137 PHE A CE1 1 
ATOM   721  C  CE2 . PHE A 1 143 ? -18.379 8.157   -27.165 1.00 35.48 ? 137 PHE A CE2 1 
ATOM   722  C  CZ  . PHE A 1 143 ? -18.033 7.793   -25.884 1.00 31.89 ? 137 PHE A CZ  1 
ATOM   723  N  N   . ARG A 1 144 ? -19.193 15.111  -26.542 1.00 21.85 ? 138 ARG A N   1 
ATOM   724  C  CA  . ARG A 1 144 ? -18.973 16.523  -26.846 1.00 29.13 ? 138 ARG A CA  1 
ATOM   725  C  C   . ARG A 1 144 ? -18.503 17.277  -25.605 1.00 24.36 ? 138 ARG A C   1 
ATOM   726  O  O   . ARG A 1 144 ? -17.492 17.985  -25.644 1.00 26.11 ? 138 ARG A O   1 
ATOM   727  C  CB  . ARG A 1 144 ? -20.257 17.142  -27.406 1.00 27.96 ? 138 ARG A CB  1 
ATOM   728  C  CG  . ARG A 1 144 ? -20.452 16.888  -28.882 1.00 36.63 ? 138 ARG A CG  1 
ATOM   729  C  CD  . ARG A 1 144 ? -20.929 18.137  -29.654 1.00 42.72 ? 138 ARG A CD  1 
ATOM   730  N  NE  . ARG A 1 144 ? -20.044 19.286  -29.492 1.00 48.85 ? 138 ARG A NE  1 
ATOM   731  C  CZ  . ARG A 1 144 ? -20.398 20.542  -29.737 1.00 43.25 ? 138 ARG A CZ  1 
ATOM   732  N  NH1 . ARG A 1 144 ? -21.629 20.850  -30.120 1.00 44.16 ? 138 ARG A NH1 1 
ATOM   733  N  NH2 . ARG A 1 144 ? -19.492 21.510  -29.614 1.00 35.84 ? 138 ARG A NH2 1 
ATOM   734  N  N   . THR A 1 145 ? -19.222 17.118  -24.484 1.00 24.76 ? 139 THR A N   1 
ATOM   735  C  CA  . THR A 1 145 ? -18.874 17.821  -23.250 1.00 24.49 ? 139 THR A CA  1 
ATOM   736  C  C   . THR A 1 145 ? -17.457 17.504  -22.797 1.00 22.94 ? 139 THR A C   1 
ATOM   737  O  O   . THR A 1 145 ? -16.750 18.385  -22.299 1.00 21.90 ? 139 THR A O   1 
ATOM   738  C  CB  . THR A 1 145 ? -19.854 17.455  -22.135 1.00 25.82 ? 139 THR A CB  1 
ATOM   739  O  OG1 . THR A 1 145 ? -21.197 17.553  -22.613 1.00 22.35 ? 139 THR A OG1 1 
ATOM   740  C  CG2 . THR A 1 145 ? -19.656 18.378  -20.915 1.00 19.66 ? 139 THR A CG2 1 
ATOM   741  N  N   . VAL A 1 146 ? -17.036 16.239  -22.920 1.00 24.75 ? 140 VAL A N   1 
ATOM   742  C  CA  . VAL A 1 146 ? -15.663 15.879  -22.556 1.00 23.33 ? 140 VAL A CA  1 
ATOM   743  C  C   . VAL A 1 146 ? -14.676 16.711  -23.360 1.00 26.17 ? 140 VAL A C   1 
ATOM   744  O  O   . VAL A 1 146 ? -13.746 17.323  -22.818 1.00 26.87 ? 140 VAL A O   1 
ATOM   745  C  CB  . VAL A 1 146 ? -15.426 14.376  -22.780 1.00 26.09 ? 140 VAL A CB  1 
ATOM   746  C  CG1 . VAL A 1 146 ? -13.930 14.063  -22.750 1.00 20.26 ? 140 VAL A CG1 1 
ATOM   747  C  CG2 . VAL A 1 146 ? -16.177 13.567  -21.747 1.00 23.08 ? 140 VAL A CG2 1 
ATOM   748  N  N   . LEU A 1 147 ? -14.865 16.740  -24.676 1.00 26.44 ? 141 LEU A N   1 
ATOM   749  C  CA  . LEU A 1 147 ? -13.956 17.490  -25.529 1.00 26.55 ? 141 LEU A CA  1 
ATOM   750  C  C   . LEU A 1 147 ? -14.004 18.984  -25.207 1.00 28.87 ? 141 LEU A C   1 
ATOM   751  O  O   . LEU A 1 147 ? -12.962 19.650  -25.199 1.00 29.61 ? 141 LEU A O   1 
ATOM   752  C  CB  . LEU A 1 147 ? -14.290 17.205  -26.992 1.00 27.71 ? 141 LEU A CB  1 
ATOM   753  C  CG  . LEU A 1 147 ? -13.682 15.894  -27.499 1.00 27.65 ? 141 LEU A CG  1 
ATOM   754  C  CD1 . LEU A 1 147 ? -14.409 15.337  -28.723 1.00 30.13 ? 141 LEU A CD1 1 
ATOM   755  C  CD2 . LEU A 1 147 ? -12.197 16.131  -27.781 1.00 26.09 ? 141 LEU A CD2 1 
ATOM   756  N  N   . ALA A 1 148 ? -15.193 19.520  -24.896 1.00 24.67 ? 142 ALA A N   1 
ATOM   757  C  CA  . ALA A 1 148 ? -15.282 20.933  -24.505 1.00 28.27 ? 142 ALA A CA  1 
ATOM   758  C  C   . ALA A 1 148 ? -14.574 21.182  -23.180 1.00 29.89 ? 142 ALA A C   1 
ATOM   759  O  O   . ALA A 1 148 ? -13.826 22.155  -23.035 1.00 28.28 ? 142 ALA A O   1 
ATOM   760  C  CB  . ALA A 1 148 ? -16.739 21.373  -24.404 1.00 24.06 ? 142 ALA A CB  1 
ATOM   761  N  N   . ALA A 1 149 ? -14.810 20.309  -22.191 1.00 27.97 ? 143 ALA A N   1 
ATOM   762  C  CA  . ALA A 1 149 ? -14.108 20.420  -20.917 1.00 24.27 ? 143 ALA A CA  1 
ATOM   763  C  C   . ALA A 1 149 ? -12.606 20.513  -21.111 1.00 26.46 ? 143 ALA A C   1 
ATOM   764  O  O   . ALA A 1 149 ? -11.922 21.202  -20.348 1.00 34.19 ? 143 ALA A O   1 
ATOM   765  C  CB  . ALA A 1 149 ? -14.438 19.218  -20.030 1.00 23.78 ? 143 ALA A CB  1 
ATOM   766  N  N   . LEU A 1 150 ? -12.071 19.813  -22.106 1.00 27.17 ? 144 LEU A N   1 
ATOM   767  C  CA  . LEU A 1 150 ? -10.647 19.847  -22.398 1.00 26.77 ? 144 LEU A CA  1 
ATOM   768  C  C   . LEU A 1 150 ? -10.276 20.989  -23.330 1.00 32.53 ? 144 LEU A C   1 
ATOM   769  O  O   . LEU A 1 150 ? -9.106  21.094  -23.714 1.00 37.30 ? 144 LEU A O   1 
ATOM   770  C  CB  . LEU A 1 150 ? -10.201 18.510  -22.998 1.00 20.35 ? 144 LEU A CB  1 
ATOM   771  C  CG  . LEU A 1 150 ? -10.477 17.283  -22.122 1.00 26.48 ? 144 LEU A CG  1 
ATOM   772  C  CD1 . LEU A 1 150 ? -10.041 16.008  -22.800 1.00 30.65 ? 144 LEU A CD1 1 
ATOM   773  C  CD2 . LEU A 1 150 ? -9.788  17.425  -20.746 1.00 22.60 ? 144 LEU A CD2 1 
ATOM   774  N  N   . GLY A 1 151 ? -11.246 21.826  -23.704 1.00 32.97 ? 145 GLY A N   1 
ATOM   775  C  CA  . GLY A 1 151 ? -11.000 23.006  -24.517 1.00 34.09 ? 145 GLY A CA  1 
ATOM   776  C  C   . GLY A 1 151 ? -10.932 22.798  -26.017 1.00 38.53 ? 145 GLY A C   1 
ATOM   777  O  O   . GLY A 1 151 ? -10.452 23.692  -26.724 1.00 36.10 ? 145 GLY A O   1 
ATOM   778  N  N   . ALA A 1 152 ? -11.422 21.665  -26.535 1.00 33.54 ? 146 ALA A N   1 
ATOM   779  C  CA  . ALA A 1 152 ? -11.318 21.371  -27.962 1.00 39.96 ? 146 ALA A CA  1 
ATOM   780  C  C   . ALA A 1 152 ? -12.542 21.782  -28.773 1.00 38.20 ? 146 ALA A C   1 
ATOM   781  O  O   . ALA A 1 152 ? -12.442 21.904  -30.000 1.00 36.26 ? 146 ALA A O   1 
ATOM   782  C  CB  . ALA A 1 152 ? -11.063 19.873  -28.185 1.00 36.20 ? 146 ALA A CB  1 
ATOM   783  N  N   . THR A 1 153 ? -13.693 21.979  -28.136 1.00 32.82 ? 147 THR A N   1 
ATOM   784  C  CA  . THR A 1 153 ? -14.902 22.347  -28.857 1.00 33.87 ? 147 THR A CA  1 
ATOM   785  C  C   . THR A 1 153 ? -15.799 23.134  -27.911 1.00 33.22 ? 147 THR A C   1 
ATOM   786  O  O   . THR A 1 153 ? -15.495 23.300  -26.731 1.00 32.71 ? 147 THR A O   1 
ATOM   787  C  CB  . THR A 1 153 ? -15.616 21.107  -29.416 1.00 35.66 ? 147 THR A CB  1 
ATOM   788  O  OG1 . THR A 1 153 ? -16.654 21.506  -30.325 1.00 39.23 ? 147 THR A OG1 1 
ATOM   789  C  CG2 . THR A 1 153 ? -16.225 20.274  -28.282 1.00 27.54 ? 147 THR A CG2 1 
ATOM   790  N  N   . GLY A 1 154 ? -16.908 23.633  -28.445 1.00 34.98 ? 148 GLY A N   1 
ATOM   791  C  CA  . GLY A 1 154 ? -17.841 24.380  -27.625 1.00 34.20 ? 148 GLY A CA  1 
ATOM   792  C  C   . GLY A 1 154 ? -18.744 23.466  -26.819 1.00 31.62 ? 148 GLY A C   1 
ATOM   793  O  O   . GLY A 1 154 ? -19.018 22.329  -27.197 1.00 30.94 ? 148 GLY A O   1 
ATOM   794  N  N   . PHE A 1 155 ? -19.211 23.973  -25.682 1.00 26.60 ? 149 PHE A N   1 
ATOM   795  C  CA  . PHE A 1 155 ? -20.123 23.185  -24.876 1.00 27.54 ? 149 PHE A CA  1 
ATOM   796  C  C   . PHE A 1 155 ? -21.471 23.042  -25.589 1.00 30.44 ? 149 PHE A C   1 
ATOM   797  O  O   . PHE A 1 155 ? -21.945 23.987  -26.226 1.00 35.01 ? 149 PHE A O   1 
ATOM   798  C  CB  . PHE A 1 155 ? -20.282 23.812  -23.493 1.00 27.75 ? 149 PHE A CB  1 
ATOM   799  C  CG  . PHE A 1 155 ? -19.093 23.581  -22.606 1.00 25.64 ? 149 PHE A CG  1 
ATOM   800  C  CD1 . PHE A 1 155 ? -18.942 22.376  -21.921 1.00 26.37 ? 149 PHE A CD1 1 
ATOM   801  C  CD2 . PHE A 1 155 ? -18.100 24.532  -22.495 1.00 23.60 ? 149 PHE A CD2 1 
ATOM   802  C  CE1 . PHE A 1 155 ? -17.844 22.144  -21.125 1.00 23.34 ? 149 PHE A CE1 1 
ATOM   803  C  CE2 . PHE A 1 155 ? -16.989 24.309  -21.697 1.00 26.89 ? 149 PHE A CE2 1 
ATOM   804  C  CZ  . PHE A 1 155 ? -16.857 23.115  -21.017 1.00 25.18 ? 149 PHE A CZ  1 
ATOM   805  N  N   . PRO A 1 156 ? -22.076 21.857  -25.554 1.00 30.33 ? 150 PRO A N   1 
ATOM   806  C  CA  . PRO A 1 156 ? -23.435 21.699  -26.093 1.00 30.59 ? 150 PRO A CA  1 
ATOM   807  C  C   . PRO A 1 156 ? -24.385 22.769  -25.566 1.00 35.20 ? 150 PRO A C   1 
ATOM   808  O  O   . PRO A 1 156 ? -24.506 22.988  -24.358 1.00 28.73 ? 150 PRO A O   1 
ATOM   809  C  CB  . PRO A 1 156 ? -23.845 20.304  -25.606 1.00 34.69 ? 150 PRO A CB  1 
ATOM   810  C  CG  . PRO A 1 156 ? -22.561 19.581  -25.339 1.00 31.98 ? 150 PRO A CG  1 
ATOM   811  C  CD  . PRO A 1 156 ? -21.547 20.619  -24.958 1.00 27.94 ? 150 PRO A CD  1 
ATOM   812  N  N   . ALA A 1 157 ? -25.074 23.442  -26.484 1.00 34.42 ? 151 ALA A N   1 
ATOM   813  C  CA  . ALA A 1 157 ? -26.062 24.454  -26.112 1.00 33.32 ? 151 ALA A CA  1 
ATOM   814  C  C   . ALA A 1 157 ? -27.402 23.784  -25.810 1.00 33.38 ? 151 ALA A C   1 
ATOM   815  O  O   . ALA A 1 157 ? -28.401 23.969  -26.506 1.00 34.38 ? 151 ALA A O   1 
ATOM   816  C  CB  . ALA A 1 157 ? -26.202 25.491  -27.218 1.00 32.24 ? 151 ALA A CB  1 
ATOM   817  N  N   . VAL A 1 158 ? -27.403 22.982  -24.747 1.00 34.74 ? 152 VAL A N   1 
ATOM   818  C  CA  . VAL A 1 158 ? -28.584 22.191  -24.410 1.00 30.66 ? 152 VAL A CA  1 
ATOM   819  C  C   . VAL A 1 158 ? -29.125 22.591  -23.044 1.00 32.42 ? 152 VAL A C   1 
ATOM   820  O  O   . VAL A 1 158 ? -28.377 23.099  -22.194 1.00 26.23 ? 152 VAL A O   1 
ATOM   821  C  CB  . VAL A 1 158 ? -28.271 20.686  -24.446 1.00 38.25 ? 152 VAL A CB  1 
ATOM   822  C  CG1 . VAL A 1 158 ? -27.774 20.272  -25.847 1.00 34.59 ? 152 VAL A CG1 1 
ATOM   823  C  CG2 . VAL A 1 158 ? -27.259 20.311  -23.346 1.00 34.79 ? 152 VAL A CG2 1 
ATOM   824  N  N   . PRO A 1 159 ? -30.415 22.381  -22.800 1.00 30.72 ? 153 PRO A N   1 
ATOM   825  C  CA  . PRO A 1 159 ? -30.954 22.585  -21.454 1.00 31.52 ? 153 PRO A CA  1 
ATOM   826  C  C   . PRO A 1 159 ? -30.240 21.678  -20.461 1.00 36.31 ? 153 PRO A C   1 
ATOM   827  O  O   . PRO A 1 159 ? -29.819 20.568  -20.799 1.00 34.47 ? 153 PRO A O   1 
ATOM   828  C  CB  . PRO A 1 159 ? -32.436 22.209  -21.597 1.00 29.53 ? 153 PRO A CB  1 
ATOM   829  C  CG  . PRO A 1 159 ? -32.722 22.332  -23.086 1.00 32.36 ? 153 PRO A CG  1 
ATOM   830  C  CD  . PRO A 1 159 ? -31.440 21.962  -23.773 1.00 26.56 ? 153 PRO A CD  1 
ATOM   831  N  N   . TRP A 1 160 ? -30.091 22.163  -19.224 1.00 28.45 ? 154 TRP A N   1 
ATOM   832  C  CA  . TRP A 1 160 ? -29.273 21.425  -18.265 1.00 29.05 ? 154 TRP A CA  1 
ATOM   833  C  C   . TRP A 1 160 ? -29.887 20.080  -17.910 1.00 31.30 ? 154 TRP A C   1 
ATOM   834  O  O   . TRP A 1 160 ? -29.185 19.204  -17.398 1.00 35.64 ? 154 TRP A O   1 
ATOM   835  C  CB  . TRP A 1 160 ? -29.068 22.242  -16.991 1.00 31.89 ? 154 TRP A CB  1 
ATOM   836  C  CG  . TRP A 1 160 ? -28.438 23.604  -17.171 1.00 26.99 ? 154 TRP A CG  1 
ATOM   837  C  CD1 . TRP A 1 160 ? -29.008 24.804  -16.875 1.00 21.63 ? 154 TRP A CD1 1 
ATOM   838  C  CD2 . TRP A 1 160 ? -27.109 23.891  -17.635 1.00 25.08 ? 154 TRP A CD2 1 
ATOM   839  N  NE1 . TRP A 1 160 ? -28.127 25.827  -17.141 1.00 23.18 ? 154 TRP A NE1 1 
ATOM   840  C  CE2 . TRP A 1 160 ? -26.952 25.294  -17.605 1.00 23.22 ? 154 TRP A CE2 1 
ATOM   841  C  CE3 . TRP A 1 160 ? -26.038 23.097  -18.077 1.00 25.87 ? 154 TRP A CE3 1 
ATOM   842  C  CZ2 . TRP A 1 160 ? -25.766 25.925  -17.987 1.00 23.11 ? 154 TRP A CZ2 1 
ATOM   843  C  CZ3 . TRP A 1 160 ? -24.868 23.719  -18.483 1.00 26.62 ? 154 TRP A CZ3 1 
ATOM   844  C  CH2 . TRP A 1 160 ? -24.741 25.126  -18.436 1.00 27.72 ? 154 TRP A CH2 1 
ATOM   845  N  N   . GLU A 1 161 ? -31.187 19.910  -18.142 1.00 29.49 ? 155 GLU A N   1 
ATOM   846  C  CA  . GLU A 1 161 ? -31.843 18.634  -17.896 1.00 37.89 ? 155 GLU A CA  1 
ATOM   847  C  C   . GLU A 1 161 ? -31.352 17.552  -18.844 1.00 38.15 ? 155 GLU A C   1 
ATOM   848  O  O   . GLU A 1 161 ? -31.618 16.368  -18.610 1.00 38.70 ? 155 GLU A O   1 
ATOM   849  C  CB  . GLU A 1 161 ? -33.356 18.789  -18.040 1.00 38.11 ? 155 GLU A CB  1 
ATOM   850  C  CG  . GLU A 1 161 ? -34.019 19.421  -16.834 1.00 44.60 ? 155 GLU A CG  1 
ATOM   851  C  CD  . GLU A 1 161 ? -33.744 20.920  -16.734 1.00 50.95 ? 155 GLU A CD  1 
ATOM   852  O  OE1 . GLU A 1 161 ? -33.652 21.597  -17.798 1.00 44.16 ? 155 GLU A OE1 1 
ATOM   853  O  OE2 . GLU A 1 161 ? -33.620 21.414  -15.583 1.00 48.12 ? 155 GLU A OE2 1 
ATOM   854  N  N   . ALA A 1 162 ? -30.675 17.943  -19.926 1.00 34.81 ? 156 ALA A N   1 
ATOM   855  C  CA  . ALA A 1 162 ? -30.122 16.963  -20.845 1.00 35.62 ? 156 ALA A CA  1 
ATOM   856  C  C   . ALA A 1 162 ? -29.218 15.988  -20.111 1.00 38.00 ? 156 ALA A C   1 
ATOM   857  O  O   . ALA A 1 162 ? -29.193 14.800  -20.441 1.00 34.25 ? 156 ALA A O   1 
ATOM   858  C  CB  . ALA A 1 162 ? -29.358 17.677  -21.958 1.00 30.46 ? 156 ALA A CB  1 
ATOM   859  N  N   . TYR A 1 163 ? -28.500 16.472  -19.092 1.00 33.71 ? 157 TYR A N   1 
ATOM   860  C  CA  . TYR A 1 163 ? -27.524 15.691  -18.350 1.00 30.37 ? 157 TYR A CA  1 
ATOM   861  C  C   . TYR A 1 163 ? -28.150 14.822  -17.271 1.00 37.68 ? 157 TYR A C   1 
ATOM   862  O  O   . TYR A 1 163 ? -27.433 14.060  -16.613 1.00 34.97 ? 157 TYR A O   1 
ATOM   863  C  CB  . TYR A 1 163 ? -26.500 16.616  -17.693 1.00 25.39 ? 157 TYR A CB  1 
ATOM   864  C  CG  . TYR A 1 163 ? -25.587 17.313  -18.659 1.00 26.89 ? 157 TYR A CG  1 
ATOM   865  C  CD1 . TYR A 1 163 ? -24.417 16.711  -19.099 1.00 23.65 ? 157 TYR A CD1 1 
ATOM   866  C  CD2 . TYR A 1 163 ? -25.884 18.586  -19.130 1.00 24.00 ? 157 TYR A CD2 1 
ATOM   867  C  CE1 . TYR A 1 163 ? -23.566 17.351  -20.004 1.00 21.00 ? 157 TYR A CE1 1 
ATOM   868  C  CE2 . TYR A 1 163 ? -25.038 19.235  -20.028 1.00 25.92 ? 157 TYR A CE2 1 
ATOM   869  C  CZ  . TYR A 1 163 ? -23.886 18.616  -20.456 1.00 23.32 ? 157 TYR A CZ  1 
ATOM   870  O  OH  . TYR A 1 163 ? -23.057 19.269  -21.326 1.00 23.84 ? 157 TYR A OH  1 
ATOM   871  N  N   . ASP A 1 164 ? -29.449 14.941  -17.043 1.00 37.03 ? 158 ASP A N   1 
ATOM   872  C  CA  . ASP A 1 164 ? -30.112 14.152  -16.024 1.00 40.11 ? 158 ASP A CA  1 
ATOM   873  C  C   . ASP A 1 164 ? -30.604 12.853  -16.652 1.00 44.01 ? 158 ASP A C   1 
ATOM   874  O  O   . ASP A 1 164 ? -31.203 12.864  -17.732 1.00 45.29 ? 158 ASP A O   1 
ATOM   875  C  CB  . ASP A 1 164 ? -31.249 14.955  -15.390 1.00 45.07 ? 158 ASP A CB  1 
ATOM   876  C  CG  . ASP A 1 164 ? -30.742 16.210  -14.654 1.00 49.33 ? 158 ASP A CG  1 
ATOM   877  O  OD1 . ASP A 1 164 ? -29.640 16.171  -14.043 1.00 45.11 ? 158 ASP A OD1 1 
ATOM   878  O  OD2 . ASP A 1 164 ? -31.437 17.248  -14.710 1.00 47.66 ? 158 ASP A OD2 1 
ATOM   879  N  N   . THR A 1 165 ? -30.307 11.736  -15.991 1.00 49.87 ? 159 THR A N   1 
ATOM   880  C  CA  . THR A 1 165 ? -30.604 10.401  -16.488 1.00 45.08 ? 159 THR A CA  1 
ATOM   881  C  C   . THR A 1 165 ? -31.296 9.581   -15.409 1.00 54.70 ? 159 THR A C   1 
ATOM   882  O  O   . THR A 1 165 ? -31.095 9.797   -14.207 1.00 48.20 ? 159 THR A O   1 
ATOM   883  C  CB  . THR A 1 165 ? -29.326 9.685   -16.935 1.00 50.46 ? 159 THR A CB  1 
ATOM   884  O  OG1 . THR A 1 165 ? -28.706 9.083   -15.790 1.00 48.36 ? 159 THR A OG1 1 
ATOM   885  C  CG2 . THR A 1 165 ? -28.351 10.665  -17.596 1.00 44.59 ? 159 THR A CG2 1 
ATOM   886  N  N   . ARG A 1 166 ? -32.113 8.626   -15.854 1.00 58.12 ? 160 ARG A N   1 
ATOM   887  C  CA  . ARG A 1 166 ? -32.763 7.709   -14.933 1.00 57.66 ? 160 ARG A CA  1 
ATOM   888  C  C   . ARG A 1 166 ? -31.708 6.958   -14.119 1.00 57.84 ? 160 ARG A C   1 
ATOM   889  O  O   . ARG A 1 166 ? -30.551 6.848   -14.535 1.00 55.16 ? 160 ARG A O   1 
ATOM   890  C  CB  . ARG A 1 166 ? -33.653 6.736   -15.710 1.00 61.60 ? 160 ARG A CB  1 
ATOM   891  C  CG  . ARG A 1 166 ? -33.709 5.323   -15.153 1.00 64.05 ? 160 ARG A CG  1 
ATOM   892  C  CD  . ARG A 1 166 ? -34.338 4.344   -16.145 1.00 68.64 ? 160 ARG A CD  1 
ATOM   893  N  NE  . ARG A 1 166 ? -33.653 4.329   -17.436 1.00 68.73 ? 160 ARG A NE  1 
ATOM   894  C  CZ  . ARG A 1 166 ? -34.158 4.804   -18.566 1.00 69.87 ? 160 ARG A CZ  1 
ATOM   895  N  NH1 . ARG A 1 166 ? -35.371 5.333   -18.615 1.00 72.44 ? 160 ARG A NH1 1 
ATOM   896  N  NH2 . ARG A 1 166 ? -33.429 4.747   -19.678 1.00 65.03 ? 160 ARG A NH2 1 
ATOM   897  N  N   . PRO A 1 167 ? -32.074 6.447   -12.941 1.00 64.33 ? 161 PRO A N   1 
ATOM   898  C  CA  . PRO A 1 167 ? -31.121 5.636   -12.161 1.00 62.86 ? 161 PRO A CA  1 
ATOM   899  C  C   . PRO A 1 167 ? -30.955 4.256   -12.789 1.00 59.35 ? 161 PRO A C   1 
ATOM   900  O  O   . PRO A 1 167 ? -31.933 3.530   -12.989 1.00 63.28 ? 161 PRO A O   1 
ATOM   901  C  CB  . PRO A 1 167 ? -31.766 5.560   -10.769 1.00 55.26 ? 161 PRO A CB  1 
ATOM   902  C  CG  . PRO A 1 167 ? -33.225 5.686   -11.036 1.00 56.06 ? 161 PRO A CG  1 
ATOM   903  C  CD  . PRO A 1 167 ? -33.352 6.630   -12.228 1.00 63.02 ? 161 PRO A CD  1 
ATOM   904  N  N   . GLN A 1 168 ? -29.707 3.904   -13.113 1.00 55.35 ? 162 GLN A N   1 
ATOM   905  C  CA  . GLN A 1 168 ? -29.382 2.602   -13.691 1.00 53.28 ? 162 GLN A CA  1 
ATOM   906  C  C   . GLN A 1 168 ? -27.999 2.155   -13.217 1.00 42.67 ? 162 GLN A C   1 
ATOM   907  O  O   . GLN A 1 168 ? -27.801 1.914   -12.022 1.00 42.91 ? 162 GLN A O   1 
ATOM   908  C  CB  . GLN A 1 168 ? -29.463 2.656   -15.228 1.00 51.59 ? 162 GLN A CB  1 
ATOM   909  C  CG  . GLN A 1 168 ? -28.844 3.906   -15.874 1.00 49.93 ? 162 GLN A CG  1 
ATOM   910  C  CD  . GLN A 1 168 ? -29.602 4.389   -17.118 1.00 57.41 ? 162 GLN A CD  1 
ATOM   911  O  OE1 . GLN A 1 168 ? -30.601 5.103   -17.016 1.00 60.41 ? 162 GLN A OE1 1 
ATOM   912  N  NE2 . GLN A 1 168 ? -29.123 3.998   -18.293 1.00 48.42 ? 162 GLN A NE2 1 
ATOM   913  N  N   . GLN A 1 169 ? -27.051 2.027   -14.145 1.00 44.11 ? 163 GLN A N   1 
ATOM   914  C  CA  . GLN A 1 169 ? -25.632 1.851   -13.833 1.00 44.20 ? 163 GLN A CA  1 
ATOM   915  C  C   . GLN A 1 169 ? -25.184 2.861   -12.778 1.00 41.16 ? 163 GLN A C   1 
ATOM   916  O  O   . GLN A 1 169 ? -25.281 4.073   -12.994 1.00 39.22 ? 163 GLN A O   1 
ATOM   917  C  CB  . GLN A 1 169 ? -24.812 2.049   -15.118 1.00 41.81 ? 163 GLN A CB  1 
ATOM   918  C  CG  . GLN A 1 169 ? -25.633 1.860   -16.387 1.00 31.69 ? 163 GLN A CG  1 
ATOM   919  C  CD  . GLN A 1 169 ? -24.860 2.202   -17.638 1.00 42.91 ? 163 GLN A CD  1 
ATOM   920  O  OE1 . GLN A 1 169 ? -23.753 1.724   -17.837 1.00 45.34 ? 163 GLN A OE1 1 
ATOM   921  N  NE2 . GLN A 1 169 ? -25.463 2.997   -18.517 1.00 49.63 ? 163 GLN A NE2 1 
ATOM   922  N  N   . SER A 1 170 ? -24.656 2.360   -11.653 1.00 38.41 ? 164 SER A N   1 
ATOM   923  C  CA  . SER A 1 170 ? -24.283 3.233   -10.539 1.00 37.76 ? 164 SER A CA  1 
ATOM   924  C  C   . SER A 1 170 ? -23.413 4.406   -10.990 1.00 42.62 ? 164 SER A C   1 
ATOM   925  O  O   . SER A 1 170 ? -23.610 5.544   -10.545 1.00 41.19 ? 164 SER A O   1 
ATOM   926  C  CB  . SER A 1 170 ? -23.555 2.419   -9.469  1.00 39.09 ? 164 SER A CB  1 
ATOM   927  O  OG  . SER A 1 170 ? -24.463 1.942   -8.480  1.00 45.48 ? 164 SER A OG  1 
ATOM   928  N  N   . TRP A 1 171 ? -22.446 4.147   -11.872 1.00 37.51 ? 165 TRP A N   1 
ATOM   929  C  CA  . TRP A 1 171 ? -21.458 5.132   -12.293 1.00 37.22 ? 165 TRP A CA  1 
ATOM   930  C  C   . TRP A 1 171 ? -21.897 5.974   -13.488 1.00 36.15 ? 165 TRP A C   1 
ATOM   931  O  O   . TRP A 1 171 ? -21.232 6.966   -13.804 1.00 31.62 ? 165 TRP A O   1 
ATOM   932  C  CB  . TRP A 1 171 ? -20.142 4.426   -12.644 1.00 32.77 ? 165 TRP A CB  1 
ATOM   933  C  CG  . TRP A 1 171 ? -20.326 3.306   -13.643 1.00 35.58 ? 165 TRP A CG  1 
ATOM   934  C  CD1 . TRP A 1 171 ? -20.343 3.423   -15.003 1.00 31.40 ? 165 TRP A CD1 1 
ATOM   935  C  CD2 . TRP A 1 171 ? -20.536 1.908   -13.358 1.00 34.67 ? 165 TRP A CD2 1 
ATOM   936  N  NE1 . TRP A 1 171 ? -20.534 2.189   -15.586 1.00 35.98 ? 165 TRP A NE1 1 
ATOM   937  C  CE2 . TRP A 1 171 ? -20.658 1.243   -14.602 1.00 34.80 ? 165 TRP A CE2 1 
ATOM   938  C  CE3 . TRP A 1 171 ? -20.620 1.157   -12.177 1.00 29.13 ? 165 TRP A CE3 1 
ATOM   939  C  CZ2 . TRP A 1 171 ? -20.864 -0.135  -14.700 1.00 29.81 ? 165 TRP A CZ2 1 
ATOM   940  C  CZ3 . TRP A 1 171 ? -20.821 -0.211  -12.277 1.00 29.30 ? 165 TRP A CZ3 1 
ATOM   941  C  CH2 . TRP A 1 171 ? -20.935 -0.845  -13.532 1.00 25.72 ? 165 TRP A CH2 1 
ATOM   942  N  N   . LEU A 1 172 ? -22.969 5.606   -14.190 1.00 36.41 ? 166 LEU A N   1 
ATOM   943  C  CA  . LEU A 1 172 ? -23.429 6.490   -15.255 1.00 36.00 ? 166 LEU A CA  1 
ATOM   944  C  C   . LEU A 1 172 ? -23.948 7.812   -14.687 1.00 33.21 ? 166 LEU A C   1 
ATOM   945  O  O   . LEU A 1 172 ? -23.719 8.882   -15.269 1.00 30.46 ? 166 LEU A O   1 
ATOM   946  C  CB  . LEU A 1 172 ? -24.505 5.805   -16.094 1.00 38.74 ? 166 LEU A CB  1 
ATOM   947  C  CG  . LEU A 1 172 ? -24.998 6.679   -17.253 1.00 41.25 ? 166 LEU A CG  1 
ATOM   948  C  CD1 . LEU A 1 172 ? -23.822 7.118   -18.138 1.00 34.61 ? 166 LEU A CD1 1 
ATOM   949  C  CD2 . LEU A 1 172 ? -26.067 5.956   -18.051 1.00 43.97 ? 166 LEU A CD2 1 
ATOM   950  N  N   . HIS A 1 173 ? -24.663 7.749   -13.562 1.00 28.75 ? 167 HIS A N   1 
ATOM   951  C  CA  . HIS A 1 173 ? -25.166 8.952   -12.909 1.00 31.29 ? 167 HIS A CA  1 
ATOM   952  C  C   . HIS A 1 173 ? -24.019 9.882   -12.539 1.00 32.87 ? 167 HIS A C   1 
ATOM   953  O  O   . HIS A 1 173 ? -24.049 11.081  -12.842 1.00 31.31 ? 167 HIS A O   1 
ATOM   954  C  CB  . HIS A 1 173 ? -25.967 8.555   -11.666 1.00 28.92 ? 167 HIS A CB  1 
ATOM   955  C  CG  . HIS A 1 173 ? -26.691 9.687   -11.012 1.00 36.06 ? 167 HIS A CG  1 
ATOM   956  N  ND1 . HIS A 1 173 ? -26.445 10.072  -9.709  1.00 34.33 ? 167 HIS A ND1 1 
ATOM   957  C  CD2 . HIS A 1 173 ? -27.679 10.499  -11.460 1.00 41.79 ? 167 HIS A CD2 1 
ATOM   958  C  CE1 . HIS A 1 173 ? -27.232 11.085  -9.390  1.00 33.08 ? 167 HIS A CE1 1 
ATOM   959  N  NE2 . HIS A 1 173 ? -27.993 11.362  -10.434 1.00 37.37 ? 167 HIS A NE2 1 
ATOM   960  N  N   . MET A 1 174 ? -22.988 9.337   -11.885 1.00 25.89 ? 168 MET A N   1 
ATOM   961  C  CA  . MET A 1 174 ? -21.822 10.138  -11.524 1.00 26.23 ? 168 MET A CA  1 
ATOM   962  C  C   . MET A 1 174 ? -21.191 10.785  -12.749 1.00 25.26 ? 168 MET A C   1 
ATOM   963  O  O   . MET A 1 174 ? -20.845 11.972  -12.726 1.00 22.42 ? 168 MET A O   1 
ATOM   964  C  CB  . MET A 1 174 ? -20.799 9.267   -10.798 1.00 26.22 ? 168 MET A CB  1 
ATOM   965  C  CG  . MET A 1 174 ? -19.410 9.874   -10.725 1.00 28.23 ? 168 MET A CG  1 
ATOM   966  S  SD  . MET A 1 174 ? -18.340 8.919   -9.611  1.00 34.29 ? 168 MET A SD  1 
ATOM   967  C  CE  . MET A 1 174 ? -19.341 9.038   -8.138  1.00 26.57 ? 168 MET A CE  1 
ATOM   968  N  N   . GLU A 1 175 ? -21.001 10.010  -13.822 1.00 22.34 ? 169 GLU A N   1 
ATOM   969  C  CA  . GLU A 1 175 ? -20.366 10.549  -15.023 1.00 21.16 ? 169 GLU A CA  1 
ATOM   970  C  C   . GLU A 1 175 ? -21.164 11.724  -15.591 1.00 24.31 ? 169 GLU A C   1 
ATOM   971  O  O   . GLU A 1 175 ? -20.596 12.766  -15.942 1.00 22.52 ? 169 GLU A O   1 
ATOM   972  C  CB  . GLU A 1 175 ? -20.209 9.442   -16.068 1.00 24.93 ? 169 GLU A CB  1 
ATOM   973  C  CG  . GLU A 1 175 ? -18.959 8.576   -15.887 1.00 26.99 ? 169 GLU A CG  1 
ATOM   974  C  CD  . GLU A 1 175 ? -19.046 7.236   -16.620 1.00 35.92 ? 169 GLU A CD  1 
ATOM   975  O  OE1 . GLU A 1 175 ? -20.041 7.002   -17.348 1.00 37.11 ? 169 GLU A OE1 1 
ATOM   976  O  OE2 . GLU A 1 175 ? -18.114 6.416   -16.467 1.00 34.31 ? 169 GLU A OE2 1 
ATOM   977  N  N   . MET A 1 176 ? -22.494 11.579  -15.673 1.00 20.79 ? 170 MET A N   1 
ATOM   978  C  CA  . MET A 1 176 ? -23.310 12.643  -16.251 1.00 23.47 ? 170 MET A CA  1 
ATOM   979  C  C   . MET A 1 176 ? -23.317 13.882  -15.355 1.00 24.69 ? 170 MET A C   1 
ATOM   980  O  O   . MET A 1 176 ? -23.191 15.009  -15.844 1.00 21.78 ? 170 MET A O   1 
ATOM   981  C  CB  . MET A 1 176 ? -24.736 12.141  -16.490 1.00 22.75 ? 170 MET A CB  1 
ATOM   982  C  CG  . MET A 1 176 ? -24.826 10.979  -17.484 1.00 31.35 ? 170 MET A CG  1 
ATOM   983  S  SD  . MET A 1 176 ? -24.434 11.501  -19.156 1.00 42.36 ? 170 MET A SD  1 
ATOM   984  C  CE  . MET A 1 176 ? -25.797 12.641  -19.467 1.00 35.51 ? 170 MET A CE  1 
ATOM   985  N  N   . LYS A 1 177 ? -23.470 13.695  -14.040 1.00 18.47 ? 171 LYS A N   1 
ATOM   986  C  CA  . LYS A 1 177 ? -23.398 14.833  -13.127 1.00 21.37 ? 171 LYS A CA  1 
ATOM   987  C  C   . LYS A 1 177 ? -22.060 15.551  -13.250 1.00 19.35 ? 171 LYS A C   1 
ATOM   988  O  O   . LYS A 1 177 ? -22.014 16.781  -13.335 1.00 19.91 ? 171 LYS A O   1 
ATOM   989  C  CB  . LYS A 1 177 ? -23.644 14.363  -11.696 1.00 24.25 ? 171 LYS A CB  1 
ATOM   990  C  CG  . LYS A 1 177 ? -25.064 13.919  -11.489 1.00 25.36 ? 171 LYS A CG  1 
ATOM   991  C  CD  . LYS A 1 177 ? -26.019 15.044  -11.842 1.00 27.07 ? 171 LYS A CD  1 
ATOM   992  C  CE  . LYS A 1 177 ? -27.214 15.049  -10.870 1.00 33.11 ? 171 LYS A CE  1 
ATOM   993  N  NZ  . LYS A 1 177 ? -28.401 15.750  -11.455 1.00 37.49 ? 171 LYS A NZ  1 
ATOM   994  N  N   . ALA A 1 178 ? -20.954 14.799  -13.279 1.00 19.65 ? 172 ALA A N   1 
ATOM   995  C  CA  . ALA A 1 178 ? -19.646 15.431  -13.454 1.00 16.48 ? 172 ALA A CA  1 
ATOM   996  C  C   . ALA A 1 178 ? -19.598 16.256  -14.731 1.00 17.73 ? 172 ALA A C   1 
ATOM   997  O  O   . ALA A 1 178 ? -19.065 17.373  -14.744 1.00 15.46 ? 172 ALA A O   1 
ATOM   998  C  CB  . ALA A 1 178 ? -18.551 14.373  -13.473 1.00 17.47 ? 172 ALA A CB  1 
ATOM   999  N  N   . LEU A 1 179 ? -20.134 15.718  -15.827 1.00 20.08 ? 173 LEU A N   1 
ATOM   1000 C  CA  . LEU A 1 179 ? -20.076 16.464  -17.078 1.00 22.52 ? 173 LEU A CA  1 
ATOM   1001 C  C   . LEU A 1 179 ? -20.960 17.702  -17.013 1.00 19.74 ? 173 LEU A C   1 
ATOM   1002 O  O   . LEU A 1 179 ? -20.592 18.755  -17.540 1.00 20.68 ? 173 LEU A O   1 
ATOM   1003 C  CB  . LEU A 1 179 ? -20.464 15.571  -18.255 1.00 19.08 ? 173 LEU A CB  1 
ATOM   1004 C  CG  . LEU A 1 179 ? -19.441 14.467  -18.555 1.00 22.33 ? 173 LEU A CG  1 
ATOM   1005 C  CD1 . LEU A 1 179 ? -20.108 13.363  -19.352 1.00 21.46 ? 173 LEU A CD1 1 
ATOM   1006 C  CD2 . LEU A 1 179 ? -18.232 15.042  -19.278 1.00 19.25 ? 173 LEU A CD2 1 
ATOM   1007 N  N   . LYS A 1 180 ? -22.126 17.598  -16.370 1.00 19.63 ? 174 LYS A N   1 
ATOM   1008 C  CA  . LYS A 1 180 ? -22.975 18.776  -16.212 1.00 20.41 ? 174 LYS A CA  1 
ATOM   1009 C  C   . LYS A 1 180 ? -22.272 19.865  -15.407 1.00 22.71 ? 174 LYS A C   1 
ATOM   1010 O  O   . LYS A 1 180 ? -22.306 21.042  -15.784 1.00 22.64 ? 174 LYS A O   1 
ATOM   1011 C  CB  . LYS A 1 180 ? -24.292 18.378  -15.556 1.00 22.71 ? 174 LYS A CB  1 
ATOM   1012 C  CG  . LYS A 1 180 ? -24.976 19.510  -14.836 1.00 25.51 ? 174 LYS A CG  1 
ATOM   1013 C  CD  . LYS A 1 180 ? -26.443 19.520  -15.140 1.00 30.65 ? 174 LYS A CD  1 
ATOM   1014 C  CE  . LYS A 1 180 ? -27.213 18.716  -14.121 1.00 35.04 ? 174 LYS A CE  1 
ATOM   1015 N  NZ  . LYS A 1 180 ? -28.493 19.393  -13.827 1.00 41.20 ? 174 LYS A NZ  1 
ATOM   1016 N  N   . VAL A 1 181 ? -21.606 19.492  -14.307 1.00 21.21 ? 175 VAL A N   1 
ATOM   1017 C  CA  . VAL A 1 181 ? -20.831 20.471  -13.538 1.00 19.22 ? 175 VAL A CA  1 
ATOM   1018 C  C   . VAL A 1 181 ? -19.744 21.101  -14.409 1.00 22.65 ? 175 VAL A C   1 
ATOM   1019 O  O   . VAL A 1 181 ? -19.533 22.319  -14.388 1.00 24.78 ? 175 VAL A O   1 
ATOM   1020 C  CB  . VAL A 1 181 ? -20.236 19.813  -12.279 1.00 21.15 ? 175 VAL A CB  1 
ATOM   1021 C  CG1 . VAL A 1 181 ? -19.147 20.702  -11.658 1.00 17.54 ? 175 VAL A CG1 1 
ATOM   1022 C  CG2 . VAL A 1 181 ? -21.351 19.463  -11.277 1.00 19.34 ? 175 VAL A CG2 1 
ATOM   1023 N  N   . LEU A 1 182 ? -19.043 20.292  -15.201 1.00 19.08 ? 176 LEU A N   1 
ATOM   1024 C  CA  . LEU A 1 182 ? -18.017 20.861  -16.061 1.00 20.51 ? 176 LEU A CA  1 
ATOM   1025 C  C   . LEU A 1 182 ? -18.620 21.816  -17.087 1.00 21.72 ? 176 LEU A C   1 
ATOM   1026 O  O   . LEU A 1 182 ? -17.990 22.810  -17.445 1.00 22.87 ? 176 LEU A O   1 
ATOM   1027 C  CB  . LEU A 1 182 ? -17.231 19.742  -16.748 1.00 21.70 ? 176 LEU A CB  1 
ATOM   1028 C  CG  . LEU A 1 182 ? -16.365 18.880  -15.821 1.00 22.87 ? 176 LEU A CG  1 
ATOM   1029 C  CD1 . LEU A 1 182 ? -15.874 17.596  -16.543 1.00 19.26 ? 176 LEU A CD1 1 
ATOM   1030 C  CD2 . LEU A 1 182 ? -15.196 19.713  -15.353 1.00 18.13 ? 176 LEU A CD2 1 
ATOM   1031 N  N   . ALA A 1 183 ? -19.844 21.554  -17.548 1.00 20.03 ? 177 ALA A N   1 
ATOM   1032 C  CA  . ALA A 1 183 ? -20.460 22.452  -18.524 1.00 22.97 ? 177 ALA A CA  1 
ATOM   1033 C  C   . ALA A 1 183 ? -20.956 23.742  -17.868 1.00 22.08 ? 177 ALA A C   1 
ATOM   1034 O  O   . ALA A 1 183 ? -20.753 24.833  -18.405 1.00 23.08 ? 177 ALA A O   1 
ATOM   1035 C  CB  . ALA A 1 183 ? -21.605 21.742  -19.249 1.00 16.75 ? 177 ALA A CB  1 
ATOM   1036 N  N   . ALA A 1 184 ? -21.605 23.630  -16.715 1.00 22.11 ? 178 ALA A N   1 
ATOM   1037 C  CA  . ALA A 1 184 ? -21.976 24.808  -15.938 1.00 23.74 ? 178 ALA A CA  1 
ATOM   1038 C  C   . ALA A 1 184 ? -20.790 25.748  -15.742 1.00 24.61 ? 178 ALA A C   1 
ATOM   1039 O  O   . ALA A 1 184 ? -20.865 26.933  -16.086 1.00 22.18 ? 178 ALA A O   1 
ATOM   1040 C  CB  . ALA A 1 184 ? -22.545 24.380  -14.589 1.00 19.89 ? 178 ALA A CB  1 
ATOM   1041 N  N   . HIS A 1 185 ? -19.685 25.229  -15.180 1.00 25.07 ? 179 HIS A N   1 
ATOM   1042 C  CA  . HIS A 1 185 ? -18.488 26.034  -14.931 1.00 21.10 ? 179 HIS A CA  1 
ATOM   1043 C  C   . HIS A 1 185 ? -17.780 26.420  -16.223 1.00 26.74 ? 179 HIS A C   1 
ATOM   1044 O  O   . HIS A 1 185 ? -17.157 27.485  -16.295 1.00 29.95 ? 179 HIS A O   1 
ATOM   1045 C  CB  . HIS A 1 185 ? -17.494 25.275  -14.061 1.00 22.40 ? 179 HIS A CB  1 
ATOM   1046 C  CG  . HIS A 1 185 ? -17.797 25.326  -12.598 1.00 28.52 ? 179 HIS A CG  1 
ATOM   1047 N  ND1 . HIS A 1 185 ? -17.068 26.094  -11.715 1.00 25.02 ? 179 HIS A ND1 1 
ATOM   1048 C  CD2 . HIS A 1 185 ? -18.733 24.688  -11.859 1.00 25.22 ? 179 HIS A CD2 1 
ATOM   1049 C  CE1 . HIS A 1 185 ? -17.550 25.932  -10.494 1.00 27.94 ? 179 HIS A CE1 1 
ATOM   1050 N  NE2 . HIS A 1 185 ? -18.566 25.093  -10.556 1.00 29.52 ? 179 HIS A NE2 1 
ATOM   1051 N  N   . GLY A 1 186 ? -17.807 25.549  -17.228 1.00 23.93 ? 180 GLY A N   1 
ATOM   1052 C  CA  . GLY A 1 186 ? -17.124 25.865  -18.474 1.00 25.31 ? 180 GLY A CA  1 
ATOM   1053 C  C   . GLY A 1 186 ? -17.774 27.021  -19.216 1.00 26.89 ? 180 GLY A C   1 
ATOM   1054 O  O   . GLY A 1 186 ? -17.087 27.891  -19.752 1.00 28.27 ? 180 GLY A O   1 
ATOM   1055 N  N   . THR A 1 187 ? -19.104 27.044  -19.255 1.00 29.67 ? 181 THR A N   1 
ATOM   1056 C  CA  . THR A 1 187 ? -19.845 28.119  -19.900 1.00 24.37 ? 181 THR A CA  1 
ATOM   1057 C  C   . THR A 1 187 ? -19.991 29.356  -19.027 1.00 25.94 ? 181 THR A C   1 
ATOM   1058 O  O   . THR A 1 187 ? -20.666 30.298  -19.443 1.00 27.25 ? 181 THR A O   1 
ATOM   1059 C  CB  . THR A 1 187 ? -21.242 27.636  -20.300 1.00 26.82 ? 181 THR A CB  1 
ATOM   1060 O  OG1 . THR A 1 187 ? -21.969 27.252  -19.119 1.00 25.95 ? 181 THR A OG1 1 
ATOM   1061 C  CG2 . THR A 1 187 ? -21.169 26.459  -21.282 1.00 25.83 ? 181 THR A CG2 1 
ATOM   1062 N  N   . GLY A 1 188 ? -19.417 29.370  -17.828 1.00 27.86 ? 182 GLY A N   1 
ATOM   1063 C  CA  . GLY A 1 188 ? -19.510 30.537  -16.973 1.00 24.99 ? 182 GLY A CA  1 
ATOM   1064 C  C   . GLY A 1 188 ? -20.799 30.652  -16.194 1.00 27.63 ? 182 GLY A C   1 
ATOM   1065 O  O   . GLY A 1 188 ? -21.210 31.763  -15.862 1.00 26.95 ? 182 GLY A O   1 
ATOM   1066 N  N   . HIS A 1 189 ? -21.451 29.534  -15.884 1.00 24.18 ? 183 HIS A N   1 
ATOM   1067 C  CA  . HIS A 1 189 ? -22.679 29.531  -15.091 1.00 22.43 ? 183 HIS A CA  1 
ATOM   1068 C  C   . HIS A 1 189 ? -22.548 28.590  -13.891 1.00 23.88 ? 183 HIS A C   1 
ATOM   1069 O  O   . HIS A 1 189 ? -23.342 27.659  -13.717 1.00 25.82 ? 183 HIS A O   1 
ATOM   1070 C  CB  . HIS A 1 189 ? -23.863 29.157  -15.979 1.00 25.29 ? 183 HIS A CB  1 
ATOM   1071 C  CG  . HIS A 1 189 ? -23.978 30.013  -17.198 1.00 27.47 ? 183 HIS A CG  1 
ATOM   1072 N  ND1 . HIS A 1 189 ? -23.527 29.612  -18.439 1.00 29.62 ? 183 HIS A ND1 1 
ATOM   1073 C  CD2 . HIS A 1 189 ? -24.462 31.268  -17.359 1.00 23.38 ? 183 HIS A CD2 1 
ATOM   1074 C  CE1 . HIS A 1 189 ? -23.743 30.579  -19.316 1.00 25.84 ? 183 HIS A CE1 1 
ATOM   1075 N  NE2 . HIS A 1 189 ? -24.313 31.592  -18.685 1.00 21.90 ? 183 HIS A NE2 1 
ATOM   1076 N  N   . PRO A 1 190 ? -21.548 28.815  -13.033 1.00 25.47 ? 184 PRO A N   1 
ATOM   1077 C  CA  . PRO A 1 190 ? -21.378 27.935  -11.865 1.00 26.00 ? 184 PRO A CA  1 
ATOM   1078 C  C   . PRO A 1 190 ? -22.589 27.887  -10.934 1.00 26.16 ? 184 PRO A C   1 
ATOM   1079 O  O   . PRO A 1 190 ? -22.843 26.821  -10.355 1.00 24.10 ? 184 PRO A O   1 
ATOM   1080 C  CB  . PRO A 1 190 ? -20.137 28.516  -11.170 1.00 24.82 ? 184 PRO A CB  1 
ATOM   1081 C  CG  . PRO A 1 190 ? -20.066 29.937  -11.627 1.00 28.47 ? 184 PRO A CG  1 
ATOM   1082 C  CD  . PRO A 1 190 ? -20.556 29.906  -13.048 1.00 27.67 ? 184 PRO A CD  1 
ATOM   1083 N  N   . ASP A 1 191 ? -23.355 28.982  -10.779 1.00 25.27 ? 185 ASP A N   1 
ATOM   1084 C  CA  . ASP A 1 191 ? -24.534 28.978  -9.900  1.00 25.96 ? 185 ASP A CA  1 
ATOM   1085 C  C   . ASP A 1 191 ? -25.616 27.994  -10.338 1.00 26.52 ? 185 ASP A C   1 
ATOM   1086 O  O   . ASP A 1 191 ? -26.537 27.722  -9.562  1.00 25.96 ? 185 ASP A O   1 
ATOM   1087 C  CB  . ASP A 1 191 ? -25.182 30.372  -9.811  1.00 30.87 ? 185 ASP A CB  1 
ATOM   1088 C  CG  . ASP A 1 191 ? -24.256 31.445  -9.219  1.00 37.97 ? 185 ASP A CG  1 
ATOM   1089 O  OD1 . ASP A 1 191 ? -23.217 31.115  -8.587  1.00 35.24 ? 185 ASP A OD1 1 
ATOM   1090 O  OD2 . ASP A 1 191 ? -24.613 32.639  -9.356  1.00 43.03 ? 185 ASP A OD2 1 
ATOM   1091 N  N   . VAL A 1 192 ? -25.556 27.483  -11.568 1.00 24.81 ? 186 VAL A N   1 
ATOM   1092 C  CA  . VAL A 1 192 ? -26.536 26.497  -12.009 1.00 26.35 ? 186 VAL A CA  1 
ATOM   1093 C  C   . VAL A 1 192 ? -26.392 25.176  -11.253 1.00 29.67 ? 186 VAL A C   1 
ATOM   1094 O  O   . VAL A 1 192 ? -27.360 24.406  -11.152 1.00 25.04 ? 186 VAL A O   1 
ATOM   1095 C  CB  . VAL A 1 192 ? -26.395 26.308  -13.533 1.00 25.66 ? 186 VAL A CB  1 
ATOM   1096 C  CG1 . VAL A 1 192 ? -26.798 24.913  -13.960 1.00 26.70 ? 186 VAL A CG1 1 
ATOM   1097 C  CG2 . VAL A 1 192 ? -27.223 27.357  -14.260 1.00 26.24 ? 186 VAL A CG2 1 
ATOM   1098 N  N   . VAL A 1 193 ? -25.207 24.891  -10.709 1.00 25.69 ? 187 VAL A N   1 
ATOM   1099 C  CA  . VAL A 1 193 ? -24.971 23.585  -10.110 1.00 26.06 ? 187 VAL A CA  1 
ATOM   1100 C  C   . VAL A 1 193 ? -25.770 23.478  -8.824  1.00 28.91 ? 187 VAL A C   1 
ATOM   1101 O  O   . VAL A 1 193 ? -25.720 24.368  -7.964  1.00 30.58 ? 187 VAL A O   1 
ATOM   1102 C  CB  . VAL A 1 193 ? -23.472 23.358  -9.867  1.00 25.01 ? 187 VAL A CB  1 
ATOM   1103 C  CG1 . VAL A 1 193 ? -23.243 21.997  -9.211  1.00 23.60 ? 187 VAL A CG1 1 
ATOM   1104 C  CG2 . VAL A 1 193 ? -22.701 23.467  -11.171 1.00 18.36 ? 187 VAL A CG2 1 
ATOM   1105 N  N   . ARG A 1 194 ? -26.527 22.398  -8.700  1.00 31.22 ? 188 ARG A N   1 
ATOM   1106 C  CA  . ARG A 1 194 ? -27.352 22.125  -7.539  1.00 35.12 ? 188 ARG A CA  1 
ATOM   1107 C  C   . ARG A 1 194 ? -26.572 21.290  -6.535  1.00 30.92 ? 188 ARG A C   1 
ATOM   1108 O  O   . ARG A 1 194 ? -25.596 20.616  -6.870  1.00 29.08 ? 188 ARG A O   1 
ATOM   1109 C  CB  . ARG A 1 194 ? -28.622 21.379  -7.951  1.00 35.72 ? 188 ARG A CB  1 
ATOM   1110 C  CG  . ARG A 1 194 ? -29.424 22.059  -9.047  1.00 40.08 ? 188 ARG A CG  1 
ATOM   1111 C  CD  . ARG A 1 194 ? -30.862 21.564  -9.018  1.00 48.57 ? 188 ARG A CD  1 
ATOM   1112 N  NE  . ARG A 1 194 ? -31.771 22.605  -8.552  1.00 65.43 ? 188 ARG A NE  1 
ATOM   1113 C  CZ  . ARG A 1 194 ? -32.955 22.384  -7.996  1.00 60.87 ? 188 ARG A CZ  1 
ATOM   1114 N  NH1 . ARG A 1 194 ? -33.406 21.155  -7.794  1.00 58.36 ? 188 ARG A NH1 1 
ATOM   1115 N  NH2 . ARG A 1 194 ? -33.699 23.423  -7.620  1.00 54.36 ? 188 ARG A NH2 1 
ATOM   1116 N  N   . ASP A 1 195 ? -27.026 21.319  -5.289  1.00 31.17 ? 189 ASP A N   1 
ATOM   1117 C  CA  . ASP A 1 195 ? -26.332 20.523  -4.291  1.00 33.65 ? 189 ASP A CA  1 
ATOM   1118 C  C   . ASP A 1 195 ? -26.512 19.035  -4.553  1.00 27.24 ? 189 ASP A C   1 
ATOM   1119 O  O   . ASP A 1 195 ? -25.636 18.243  -4.193  1.00 28.62 ? 189 ASP A O   1 
ATOM   1120 C  CB  . ASP A 1 195 ? -26.781 20.927  -2.885  1.00 38.80 ? 189 ASP A CB  1 
ATOM   1121 C  CG  . ASP A 1 195 ? -25.958 22.104  -2.330  1.00 38.46 ? 189 ASP A CG  1 
ATOM   1122 O  OD1 . ASP A 1 195 ? -25.038 22.568  -3.037  1.00 34.72 ? 189 ASP A OD1 1 
ATOM   1123 O  OD2 . ASP A 1 195 ? -26.216 22.558  -1.191  1.00 34.16 ? 189 ASP A OD2 1 
ATOM   1124 N  N   . GLU A 1 196 ? -27.594 18.635  -5.234  1.00 28.23 ? 190 GLU A N   1 
ATOM   1125 C  CA  . GLU A 1 196 ? -27.727 17.223  -5.586  1.00 30.90 ? 190 GLU A CA  1 
ATOM   1126 C  C   . GLU A 1 196 ? -26.712 16.814  -6.651  1.00 27.06 ? 190 GLU A C   1 
ATOM   1127 O  O   . GLU A 1 196 ? -26.267 15.665  -6.665  1.00 27.41 ? 190 GLU A O   1 
ATOM   1128 C  CB  . GLU A 1 196 ? -29.145 16.914  -6.051  1.00 33.30 ? 190 GLU A CB  1 
ATOM   1129 C  CG  . GLU A 1 196 ? -29.531 17.625  -7.334  1.00 38.06 ? 190 GLU A CG  1 
ATOM   1130 C  CD  . GLU A 1 196 ? -31.031 17.802  -7.473  1.00 47.40 ? 190 GLU A CD  1 
ATOM   1131 O  OE1 . GLU A 1 196 ? -31.769 16.796  -7.352  1.00 45.19 ? 190 GLU A OE1 1 
ATOM   1132 O  OE2 . GLU A 1 196 ? -31.469 18.956  -7.698  1.00 55.53 ? 190 GLU A OE2 1 
ATOM   1133 N  N   . ASP A 1 197 ? -26.316 17.738  -7.530  1.00 24.07 ? 191 ASP A N   1 
ATOM   1134 C  CA  . ASP A 1 197 ? -25.262 17.442  -8.499  1.00 27.23 ? 191 ASP A CA  1 
ATOM   1135 C  C   . ASP A 1 197 ? -23.945 17.116  -7.795  1.00 21.20 ? 191 ASP A C   1 
ATOM   1136 O  O   . ASP A 1 197 ? -23.264 16.148  -8.145  1.00 20.99 ? 191 ASP A O   1 
ATOM   1137 C  CB  . ASP A 1 197 ? -25.062 18.623  -9.472  1.00 27.04 ? 191 ASP A CB  1 
ATOM   1138 C  CG  . ASP A 1 197 ? -26.354 19.062  -10.172 1.00 29.29 ? 191 ASP A CG  1 
ATOM   1139 O  OD1 . ASP A 1 197 ? -27.253 18.229  -10.410 1.00 30.49 ? 191 ASP A OD1 1 
ATOM   1140 O  OD2 . ASP A 1 197 ? -26.473 20.266  -10.478 1.00 32.32 ? 191 ASP A OD2 1 
ATOM   1141 N  N   . TRP A 1 198 ? -23.555 17.939  -6.819  1.00 22.59 ? 192 TRP A N   1 
ATOM   1142 C  CA  . TRP A 1 198 ? -22.307 17.696  -6.104  1.00 22.64 ? 192 TRP A CA  1 
ATOM   1143 C  C   . TRP A 1 198 ? -22.346 16.369  -5.365  1.00 21.92 ? 192 TRP A C   1 
ATOM   1144 O  O   . TRP A 1 198 ? -21.353 15.632  -5.350  1.00 19.91 ? 192 TRP A O   1 
ATOM   1145 C  CB  . TRP A 1 198 ? -22.020 18.811  -5.098  1.00 22.99 ? 192 TRP A CB  1 
ATOM   1146 C  CG  . TRP A 1 198 ? -21.685 20.154  -5.657  1.00 23.72 ? 192 TRP A CG  1 
ATOM   1147 C  CD1 . TRP A 1 198 ? -22.343 21.318  -5.405  1.00 23.28 ? 192 TRP A CD1 1 
ATOM   1148 C  CD2 . TRP A 1 198 ? -20.578 20.495  -6.502  1.00 24.83 ? 192 TRP A CD2 1 
ATOM   1149 N  NE1 . TRP A 1 198 ? -21.730 22.358  -6.061  1.00 22.53 ? 192 TRP A NE1 1 
ATOM   1150 C  CE2 . TRP A 1 198 ? -20.643 21.881  -6.737  1.00 24.98 ? 192 TRP A CE2 1 
ATOM   1151 C  CE3 . TRP A 1 198 ? -19.552 19.762  -7.100  1.00 25.89 ? 192 TRP A CE3 1 
ATOM   1152 C  CZ2 . TRP A 1 198 ? -19.727 22.547  -7.554  1.00 29.41 ? 192 TRP A CZ2 1 
ATOM   1153 C  CZ3 . TRP A 1 198 ? -18.634 20.426  -7.904  1.00 20.67 ? 192 TRP A CZ3 1 
ATOM   1154 C  CH2 . TRP A 1 198 ? -18.727 21.800  -8.119  1.00 27.22 ? 192 TRP A CH2 1 
ATOM   1155 N  N   . ARG A 1 199 ? -23.480 16.061  -4.730  1.00 22.19 ? 193 ARG A N   1 
ATOM   1156 C  CA  . ARG A 1 199 ? -23.556 14.904  -3.839  1.00 25.19 ? 193 ARG A CA  1 
ATOM   1157 C  C   . ARG A 1 199 ? -23.379 13.598  -4.603  1.00 22.02 ? 193 ARG A C   1 
ATOM   1158 O  O   . ARG A 1 199 ? -22.930 12.596  -4.034  1.00 23.76 ? 193 ARG A O   1 
ATOM   1159 C  CB  . ARG A 1 199 ? -24.894 14.915  -3.092  1.00 23.45 ? 193 ARG A CB  1 
ATOM   1160 C  CG  . ARG A 1 199 ? -25.002 13.966  -1.914  1.00 26.01 ? 193 ARG A CG  1 
ATOM   1161 C  CD  . ARG A 1 199 ? -26.472 13.615  -1.622  1.00 29.08 ? 193 ARG A CD  1 
ATOM   1162 N  NE  . ARG A 1 199 ? -26.762 13.565  -0.191  1.00 28.63 ? 193 ARG A NE  1 
ATOM   1163 C  CZ  . ARG A 1 199 ? -26.272 12.639  0.626   1.00 32.56 ? 193 ARG A CZ  1 
ATOM   1164 N  NH1 . ARG A 1 199 ? -25.425 11.713  0.196   1.00 30.06 ? 193 ARG A NH1 1 
ATOM   1165 N  NH2 . ARG A 1 199 ? -26.646 12.634  1.906   1.00 25.98 ? 193 ARG A NH2 1 
ATOM   1166 N  N   . ALA A 1 200 ? -23.729 13.587  -5.882  1.00 24.42 ? 194 ALA A N   1 
ATOM   1167 C  CA  . ALA A 1 200 ? -23.487 12.404  -6.701  1.00 24.30 ? 194 ALA A CA  1 
ATOM   1168 C  C   . ALA A 1 200 ? -21.997 12.151  -6.904  1.00 23.12 ? 194 ALA A C   1 
ATOM   1169 O  O   . ALA A 1 200 ? -21.609 11.048  -7.308  1.00 19.17 ? 194 ALA A O   1 
ATOM   1170 C  CB  . ALA A 1 200 ? -24.184 12.561  -8.055  1.00 23.65 ? 194 ALA A CB  1 
ATOM   1171 N  N   . LEU A 1 201 ? -21.155 13.151  -6.655  1.00 18.75 ? 195 LEU A N   1 
ATOM   1172 C  CA  . LEU A 1 201 ? -19.737 13.016  -6.927  1.00 17.37 ? 195 LEU A CA  1 
ATOM   1173 C  C   . LEU A 1 201 ? -18.937 12.567  -5.707  1.00 19.92 ? 195 LEU A C   1 
ATOM   1174 O  O   . LEU A 1 201 ? -17.751 12.242  -5.849  1.00 16.15 ? 195 LEU A O   1 
ATOM   1175 C  CB  . LEU A 1 201 ? -19.185 14.345  -7.465  1.00 17.05 ? 195 LEU A CB  1 
ATOM   1176 C  CG  . LEU A 1 201 ? -19.903 14.900  -8.706  1.00 17.86 ? 195 LEU A CG  1 
ATOM   1177 C  CD1 . LEU A 1 201 ? -19.274 16.184  -9.174  1.00 17.95 ? 195 LEU A CD1 1 
ATOM   1178 C  CD2 . LEU A 1 201 ? -19.930 13.869  -9.869  1.00 21.84 ? 195 LEU A CD2 1 
ATOM   1179 N  N   . LEU A 1 202 ? -19.557 12.518  -4.527  1.00 18.94 ? 196 LEU A N   1 
ATOM   1180 C  CA  . LEU A 1 202 ? -18.785 12.300  -3.305  1.00 20.30 ? 196 LEU A CA  1 
ATOM   1181 C  C   . LEU A 1 202 ? -17.994 10.994  -3.298  1.00 19.66 ? 196 LEU A C   1 
ATOM   1182 O  O   . LEU A 1 202 ? -16.895 10.978  -2.719  1.00 22.13 ? 196 LEU A O   1 
ATOM   1183 C  CB  . LEU A 1 202 ? -19.716 12.379  -2.086  1.00 18.67 ? 196 LEU A CB  1 
ATOM   1184 C  CG  . LEU A 1 202 ? -20.344 13.751  -1.837  1.00 15.67 ? 196 LEU A CG  1 
ATOM   1185 C  CD1 . LEU A 1 202 ? -21.295 13.755  -0.627  1.00 20.61 ? 196 LEU A CD1 1 
ATOM   1186 C  CD2 . LEU A 1 202 ? -19.263 14.758  -1.672  1.00 18.99 ? 196 LEU A CD2 1 
ATOM   1187 N  N   . PRO A 1 203 ? -18.450 9.892   -3.896  1.00 17.10 ? 197 PRO A N   1 
ATOM   1188 C  CA  . PRO A 1 203 ? -17.635 8.667   -3.848  1.00 19.27 ? 197 PRO A CA  1 
ATOM   1189 C  C   . PRO A 1 203 ? -16.248 8.849   -4.454  1.00 21.37 ? 197 PRO A C   1 
ATOM   1190 O  O   . PRO A 1 203 ? -15.332 8.066   -4.162  1.00 19.27 ? 197 PRO A O   1 
ATOM   1191 C  CB  . PRO A 1 203 ? -18.475 7.658   -4.637  1.00 21.31 ? 197 PRO A CB  1 
ATOM   1192 C  CG  . PRO A 1 203 ? -19.863 8.176   -4.574  1.00 23.10 ? 197 PRO A CG  1 
ATOM   1193 C  CD  . PRO A 1 203 ? -19.746 9.667   -4.559  1.00 21.22 ? 197 PRO A CD  1 
ATOM   1194 N  N   . ALA A 1 204 ? -16.072 9.851   -5.308  1.00 17.80 ? 198 ALA A N   1 
ATOM   1195 C  CA  . ALA A 1 204 ? -14.806 10.087  -5.967  1.00 16.58 ? 198 ALA A CA  1 
ATOM   1196 C  C   . ALA A 1 204 ? -13.753 10.646  -5.027  1.00 20.04 ? 198 ALA A C   1 
ATOM   1197 O  O   . ALA A 1 204 ? -12.579 10.698  -5.413  1.00 17.33 ? 198 ALA A O   1 
ATOM   1198 C  CB  . ALA A 1 204 ? -15.009 11.060  -7.139  1.00 15.92 ? 198 ALA A CB  1 
ATOM   1199 N  N   . LEU A 1 205 ? -14.140 11.102  -3.832  1.00 14.87 ? 199 LEU A N   1 
ATOM   1200 C  CA  . LEU A 1 205 ? -13.199 11.641  -2.858  1.00 17.13 ? 199 LEU A CA  1 
ATOM   1201 C  C   . LEU A 1 205 ? -12.806 10.629  -1.784  1.00 22.22 ? 199 LEU A C   1 
ATOM   1202 O  O   . LEU A 1 205 ? -12.085 10.986  -0.843  1.00 21.69 ? 199 LEU A O   1 
ATOM   1203 C  CB  . LEU A 1 205 ? -13.790 12.882  -2.195  1.00 16.80 ? 199 LEU A CB  1 
ATOM   1204 C  CG  . LEU A 1 205 ? -14.091 14.033  -3.144  1.00 17.13 ? 199 LEU A CG  1 
ATOM   1205 C  CD1 . LEU A 1 205 ? -15.042 15.019  -2.482  1.00 16.95 ? 199 LEU A CD1 1 
ATOM   1206 C  CD2 . LEU A 1 205 ? -12.776 14.698  -3.554  1.00 15.92 ? 199 LEU A CD2 1 
ATOM   1207 N  N   . GLU A 1 206 ? -13.293 9.383   -1.885  1.00 22.40 ? 200 GLU A N   1 
ATOM   1208 C  CA  . GLU A 1 206 ? -12.887 8.300   -1.005  1.00 24.48 ? 200 GLU A CA  1 
ATOM   1209 C  C   . GLU A 1 206 ? -11.478 7.837   -1.368  1.00 27.00 ? 200 GLU A C   1 
ATOM   1210 O  O   . GLU A 1 206 ? -11.150 7.717   -2.553  1.00 26.22 ? 200 GLU A O   1 
ATOM   1211 C  CB  . GLU A 1 206 ? -13.853 7.130   -1.123  1.00 24.42 ? 200 GLU A CB  1 
ATOM   1212 C  CG  . GLU A 1 206 ? -15.243 7.458   -0.644  1.00 24.02 ? 200 GLU A CG  1 
ATOM   1213 C  CD  . GLU A 1 206 ? -16.314 6.544   -1.232  1.00 28.34 ? 200 GLU A CD  1 
ATOM   1214 O  OE1 . GLU A 1 206 ? -15.987 5.647   -2.047  1.00 29.51 ? 200 GLU A OE1 1 
ATOM   1215 O  OE2 . GLU A 1 206 ? -17.497 6.738   -0.879  1.00 30.86 ? 200 GLU A OE2 1 
ATOM   1216 N  N   . PRO A 1 207 ? -10.630 7.562   -0.381  1.00 27.60 ? 201 PRO A N   1 
ATOM   1217 C  CA  . PRO A 1 207 ? -9.279  7.082   -0.689  1.00 28.91 ? 201 PRO A CA  1 
ATOM   1218 C  C   . PRO A 1 207 ? -9.339  5.684   -1.299  1.00 31.20 ? 201 PRO A C   1 
ATOM   1219 O  O   . PRO A 1 207 ? -10.363 4.995   -1.258  1.00 29.83 ? 201 PRO A O   1 
ATOM   1220 C  CB  . PRO A 1 207 ? -8.584  7.082   0.675   1.00 28.99 ? 201 PRO A CB  1 
ATOM   1221 C  CG  . PRO A 1 207 ? -9.705  6.884   1.653   1.00 29.98 ? 201 PRO A CG  1 
ATOM   1222 C  CD  . PRO A 1 207 ? -10.888 7.611   1.071   1.00 27.48 ? 201 PRO A CD  1 
ATOM   1223 N  N   . GLY A 1 208 ? -8.223  5.277   -1.905  1.00 28.88 ? 202 GLY A N   1 
ATOM   1224 C  CA  . GLY A 1 208 ? -8.096  3.927   -2.406  1.00 30.62 ? 202 GLY A CA  1 
ATOM   1225 C  C   . GLY A 1 208 ? -8.548  3.782   -3.843  1.00 29.01 ? 202 GLY A C   1 
ATOM   1226 O  O   . GLY A 1 208 ? -8.670  4.762   -4.583  1.00 25.86 ? 202 GLY A O   1 
ATOM   1227 N  N   . PRO A 1 209 ? -8.765  2.545   -4.284  1.00 35.90 ? 203 PRO A N   1 
ATOM   1228 C  CA  . PRO A 1 209 ? -9.115  2.330   -5.691  1.00 28.81 ? 203 PRO A CA  1 
ATOM   1229 C  C   . PRO A 1 209 ? -10.422 3.030   -6.030  1.00 24.66 ? 203 PRO A C   1 
ATOM   1230 O  O   . PRO A 1 209 ? -11.277 3.261   -5.173  1.00 24.79 ? 203 PRO A O   1 
ATOM   1231 C  CB  . PRO A 1 209 ? -9.247  0.808   -5.796  1.00 32.11 ? 203 PRO A CB  1 
ATOM   1232 C  CG  . PRO A 1 209 ? -8.536  0.271   -4.597  1.00 30.10 ? 203 PRO A CG  1 
ATOM   1233 C  CD  . PRO A 1 209 ? -8.697  1.282   -3.531  1.00 31.29 ? 203 PRO A CD  1 
ATOM   1234 N  N   . ALA A 1 210 ? -10.566 3.372   -7.300  1.00 23.90 ? 204 ALA A N   1 
ATOM   1235 C  CA  . ALA A 1 210 ? -11.762 4.064   -7.744  1.00 21.79 ? 204 ALA A CA  1 
ATOM   1236 C  C   . ALA A 1 210 ? -13.012 3.305   -7.312  1.00 25.66 ? 204 ALA A C   1 
ATOM   1237 O  O   . ALA A 1 210 ? -13.054 2.067   -7.316  1.00 21.15 ? 204 ALA A O   1 
ATOM   1238 C  CB  . ALA A 1 210 ? -11.730 4.236   -9.267  1.00 16.78 ? 204 ALA A CB  1 
ATOM   1239 N  N   . TRP A 1 211 ? -14.026 4.068   -6.912  1.00 20.62 ? 205 TRP A N   1 
ATOM   1240 C  CA  . TRP A 1 211 ? -15.356 3.520   -6.678  1.00 23.16 ? 205 TRP A CA  1 
ATOM   1241 C  C   . TRP A 1 211 ? -15.836 2.695   -7.876  1.00 20.96 ? 205 TRP A C   1 
ATOM   1242 O  O   . TRP A 1 211 ? -15.722 3.117   -9.031  1.00 19.12 ? 205 TRP A O   1 
ATOM   1243 C  CB  . TRP A 1 211 ? -16.300 4.677   -6.411  1.00 21.09 ? 205 TRP A CB  1 
ATOM   1244 C  CG  . TRP A 1 211 ? -17.713 4.349   -6.144  1.00 24.17 ? 205 TRP A CG  1 
ATOM   1245 C  CD1 . TRP A 1 211 ? -18.227 3.716   -5.049  1.00 31.15 ? 205 TRP A CD1 1 
ATOM   1246 C  CD2 . TRP A 1 211 ? -18.823 4.700   -6.965  1.00 22.49 ? 205 TRP A CD2 1 
ATOM   1247 N  NE1 . TRP A 1 211 ? -19.599 3.635   -5.151  1.00 28.22 ? 205 TRP A NE1 1 
ATOM   1248 C  CE2 . TRP A 1 211 ? -19.989 4.235   -6.320  1.00 22.59 ? 205 TRP A CE2 1 
ATOM   1249 C  CE3 . TRP A 1 211 ? -18.945 5.350   -8.196  1.00 27.24 ? 205 TRP A CE3 1 
ATOM   1250 C  CZ2 . TRP A 1 211 ? -21.258 4.394   -6.863  1.00 28.23 ? 205 TRP A CZ2 1 
ATOM   1251 C  CZ3 . TRP A 1 211 ? -20.220 5.509   -8.739  1.00 34.81 ? 205 TRP A CZ3 1 
ATOM   1252 C  CH2 . TRP A 1 211 ? -21.356 5.034   -8.068  1.00 32.53 ? 205 TRP A CH2 1 
ATOM   1253 N  N   . GLU A 1 212 ? -16.375 1.518   -7.593  1.00 19.39 ? 206 GLU A N   1 
ATOM   1254 C  CA  . GLU A 1 212 ? -16.844 0.597   -8.633  1.00 21.87 ? 206 GLU A CA  1 
ATOM   1255 C  C   . GLU A 1 212 ? -15.754 0.282   -9.656  1.00 18.12 ? 206 GLU A C   1 
ATOM   1256 O  O   . GLU A 1 212 ? -16.054 -0.061  -10.795 1.00 20.44 ? 206 GLU A O   1 
ATOM   1257 C  CB  . GLU A 1 212 ? -18.087 1.144   -9.346  1.00 19.42 ? 206 GLU A CB  1 
ATOM   1258 C  CG  . GLU A 1 212 ? -19.296 1.324   -8.442  1.00 21.73 ? 206 GLU A CG  1 
ATOM   1259 C  CD  . GLU A 1 212 ? -19.857 0.002   -7.926  1.00 23.93 ? 206 GLU A CD  1 
ATOM   1260 O  OE1 . GLU A 1 212 ? -19.221 -0.639  -7.050  1.00 24.83 ? 206 GLU A OE1 1 
ATOM   1261 O  OE2 . GLU A 1 212 ? -20.948 -0.390  -8.390  1.00 25.95 ? 206 GLU A OE2 1 
ATOM   1262 N  N   . CYS A 1 213 ? -14.483 0.398   -9.269  1.00 16.79 ? 207 CYS A N   1 
ATOM   1263 C  CA  . CYS A 1 213 ? -13.355 0.089   -10.142 1.00 19.35 ? 207 CYS A CA  1 
ATOM   1264 C  C   . CYS A 1 213 ? -13.342 0.904   -11.436 1.00 19.47 ? 207 CYS A C   1 
ATOM   1265 O  O   . CYS A 1 213 ? -12.715 0.489   -12.409 1.00 17.53 ? 207 CYS A O   1 
ATOM   1266 C  CB  . CYS A 1 213 ? -13.317 -1.412  -10.473 1.00 23.65 ? 207 CYS A CB  1 
ATOM   1267 S  SG  . CYS A 1 213 ? -13.175 -2.432  -8.965  1.00 20.56 ? 207 CYS A SG  1 
ATOM   1268 N  N   . ASN A 1 214 ? -13.967 2.084   -11.476 1.00 20.51 ? 208 ASN A N   1 
ATOM   1269 C  CA  . ASN A 1 214 ? -14.112 2.850   -12.726 1.00 17.23 ? 208 ASN A CA  1 
ATOM   1270 C  C   . ASN A 1 214 ? -13.255 4.109   -12.650 1.00 17.21 ? 208 ASN A C   1 
ATOM   1271 O  O   . ASN A 1 214 ? -13.663 5.117   -12.061 1.00 18.64 ? 208 ASN A O   1 
ATOM   1272 C  CB  . ASN A 1 214 ? -15.578 3.184   -12.989 1.00 18.73 ? 208 ASN A CB  1 
ATOM   1273 C  CG  . ASN A 1 214 ? -15.836 3.638   -14.413 1.00 21.22 ? 208 ASN A CG  1 
ATOM   1274 O  OD1 . ASN A 1 214 ? -15.109 4.474   -14.961 1.00 21.48 ? 208 ASN A OD1 1 
ATOM   1275 N  ND2 . ASN A 1 214 ? -16.889 3.092   -15.022 1.00 25.84 ? 208 ASN A ND2 1 
ATOM   1276 N  N   . ASN A 1 215 ? -12.065 4.044   -13.252 1.00 17.84 ? 209 ASN A N   1 
ATOM   1277 C  CA  . ASN A 1 215 ? -11.176 5.200   -13.282 1.00 19.53 ? 209 ASN A CA  1 
ATOM   1278 C  C   . ASN A 1 215 ? -11.772 6.352   -14.086 1.00 18.88 ? 209 ASN A C   1 
ATOM   1279 O  O   . ASN A 1 215 ? -11.556 7.518   -13.743 1.00 17.96 ? 209 ASN A O   1 
ATOM   1280 C  CB  . ASN A 1 215 ? -9.816  4.810   -13.856 1.00 17.47 ? 209 ASN A CB  1 
ATOM   1281 C  CG  . ASN A 1 215 ? -9.072  3.863   -12.952 1.00 25.11 ? 209 ASN A CG  1 
ATOM   1282 O  OD1 . ASN A 1 215 ? -9.089  4.022   -11.726 1.00 18.81 ? 209 ASN A OD1 1 
ATOM   1283 N  ND2 . ASN A 1 215 ? -8.447  2.838   -13.544 1.00 19.74 ? 209 ASN A ND2 1 
ATOM   1284 N  N   . LEU A 1 216 ? -12.495 6.058   -15.170 1.00 17.20 ? 210 LEU A N   1 
ATOM   1285 C  CA  . LEU A 1 216 ? -13.093 7.138   -15.954 1.00 18.42 ? 210 LEU A CA  1 
ATOM   1286 C  C   . LEU A 1 216 ? -14.061 7.945   -15.104 1.00 18.55 ? 210 LEU A C   1 
ATOM   1287 O  O   . LEU A 1 216 ? -13.994 9.178   -15.063 1.00 17.78 ? 210 LEU A O   1 
ATOM   1288 C  CB  . LEU A 1 216 ? -13.805 6.573   -17.186 1.00 17.92 ? 210 LEU A CB  1 
ATOM   1289 C  CG  . LEU A 1 216 ? -14.612 7.582   -18.004 1.00 23.63 ? 210 LEU A CG  1 
ATOM   1290 C  CD1 . LEU A 1 216 ? -13.716 8.730   -18.497 1.00 19.14 ? 210 LEU A CD1 1 
ATOM   1291 C  CD2 . LEU A 1 216 ? -15.323 6.907   -19.200 1.00 22.01 ? 210 LEU A CD2 1 
ATOM   1292 N  N   . ALA A 1 217 ? -14.967 7.258   -14.405 1.00 18.86 ? 211 ALA A N   1 
ATOM   1293 C  CA  . ALA A 1 217 ? -15.943 7.949   -13.570 1.00 19.07 ? 211 ALA A CA  1 
ATOM   1294 C  C   . ALA A 1 217 ? -15.256 8.804   -12.517 1.00 18.90 ? 211 ALA A C   1 
ATOM   1295 O  O   . ALA A 1 217 ? -15.619 9.972   -12.322 1.00 18.37 ? 211 ALA A O   1 
ATOM   1296 C  CB  . ALA A 1 217 ? -16.885 6.935   -12.915 1.00 20.39 ? 211 ALA A CB  1 
ATOM   1297 N  N   . GLN A 1 218 ? -14.245 8.253   -11.833 1.00 16.42 ? 212 GLN A N   1 
ATOM   1298 C  CA  . GLN A 1 218 ? -13.585 9.033   -10.782 1.00 18.70 ? 212 GLN A CA  1 
ATOM   1299 C  C   . GLN A 1 218 ? -12.862 10.235  -11.370 1.00 17.50 ? 212 GLN A C   1 
ATOM   1300 O  O   . GLN A 1 218 ? -12.930 11.341  -10.816 1.00 17.69 ? 212 GLN A O   1 
ATOM   1301 C  CB  . GLN A 1 218 ? -12.601 8.178   -9.963  1.00 17.70 ? 212 GLN A CB  1 
ATOM   1302 C  CG  . GLN A 1 218 ? -11.907 8.978   -8.804  1.00 19.56 ? 212 GLN A CG  1 
ATOM   1303 C  CD  . GLN A 1 218 ? -11.075 8.113   -7.856  1.00 22.37 ? 212 GLN A CD  1 
ATOM   1304 O  OE1 . GLN A 1 218 ? -10.562 7.058   -8.240  1.00 18.95 ? 212 GLN A OE1 1 
ATOM   1305 N  NE2 . GLN A 1 218 ? -10.935 8.564   -6.609  1.00 19.38 ? 212 GLN A NE2 1 
ATOM   1306 N  N   . LEU A 1 219 ? -12.162 10.037  -12.489 1.00 16.06 ? 213 LEU A N   1 
ATOM   1307 C  CA  . LEU A 1 219 ? -11.434 11.136  -13.111 1.00 19.77 ? 213 LEU A CA  1 
ATOM   1308 C  C   . LEU A 1 219 ? -12.377 12.256  -13.548 1.00 19.79 ? 213 LEU A C   1 
ATOM   1309 O  O   . LEU A 1 219 ? -12.072 13.440  -13.377 1.00 17.08 ? 213 LEU A O   1 
ATOM   1310 C  CB  . LEU A 1 219 ? -10.639 10.623  -14.309 1.00 15.19 ? 213 LEU A CB  1 
ATOM   1311 C  CG  . LEU A 1 219 ? -9.420  9.784   -13.937 1.00 22.61 ? 213 LEU A CG  1 
ATOM   1312 C  CD1 . LEU A 1 219 ? -8.834  9.159   -15.197 1.00 18.42 ? 213 LEU A CD1 1 
ATOM   1313 C  CD2 . LEU A 1 219 ? -8.383  10.639  -13.194 1.00 17.48 ? 213 LEU A CD2 1 
ATOM   1314 N  N   . LEU A 1 220 ? -13.500 11.909  -14.167 1.00 14.56 ? 214 LEU A N   1 
ATOM   1315 C  CA  . LEU A 1 220 ? -14.438 12.952  -14.544 1.00 18.30 ? 214 LEU A CA  1 
ATOM   1316 C  C   . LEU A 1 220 ? -14.947 13.677  -13.305 1.00 19.95 ? 214 LEU A C   1 
ATOM   1317 O  O   . LEU A 1 220 ? -14.966 14.911  -13.260 1.00 17.96 ? 214 LEU A O   1 
ATOM   1318 C  CB  . LEU A 1 220 ? -15.587 12.351  -15.350 1.00 15.91 ? 214 LEU A CB  1 
ATOM   1319 C  CG  . LEU A 1 220 ? -15.205 12.064  -16.806 1.00 19.66 ? 214 LEU A CG  1 
ATOM   1320 C  CD1 . LEU A 1 220 ? -16.400 11.517  -17.556 1.00 15.21 ? 214 LEU A CD1 1 
ATOM   1321 C  CD2 . LEU A 1 220 ? -14.686 13.335  -17.464 1.00 13.27 ? 214 LEU A CD2 1 
ATOM   1322 N  N   . ALA A 1 221 ? -15.337 12.915  -12.277 1.00 14.86 ? 215 ALA A N   1 
ATOM   1323 C  CA  . ALA A 1 221 ? -15.820 13.512  -11.037 1.00 17.86 ? 215 ALA A CA  1 
ATOM   1324 C  C   . ALA A 1 221 ? -14.773 14.435  -10.429 1.00 17.25 ? 215 ALA A C   1 
ATOM   1325 O  O   . ALA A 1 221 ? -15.094 15.548  -10.009 1.00 15.58 ? 215 ALA A O   1 
ATOM   1326 C  CB  . ALA A 1 221 ? -16.228 12.412  -10.042 1.00 12.43 ? 215 ALA A CB  1 
ATOM   1327 N  N   . LEU A 1 222 ? -13.509 14.000  -10.397 1.00 15.14 ? 216 LEU A N   1 
ATOM   1328 C  CA  . LEU A 1 222 ? -12.460 14.824  -9.813  1.00 16.03 ? 216 LEU A CA  1 
ATOM   1329 C  C   . LEU A 1 222 ? -12.229 16.086  -10.628 1.00 20.61 ? 216 LEU A C   1 
ATOM   1330 O  O   . LEU A 1 222 ? -11.902 17.136  -10.063 1.00 17.32 ? 216 LEU A O   1 
ATOM   1331 C  CB  . LEU A 1 222 ? -11.159 14.027  -9.688  1.00 18.02 ? 216 LEU A CB  1 
ATOM   1332 C  CG  . LEU A 1 222 ? -11.211 12.852  -8.699  1.00 19.20 ? 216 LEU A CG  1 
ATOM   1333 C  CD1 . LEU A 1 222 ? -9.855  12.157  -8.571  1.00 17.85 ? 216 LEU A CD1 1 
ATOM   1334 C  CD2 . LEU A 1 222 ? -11.699 13.358  -7.336  1.00 18.28 ? 216 LEU A CD2 1 
ATOM   1335 N  N   . LEU A 1 223 ? -12.368 16.005  -11.960 1.00 16.33 ? 217 LEU A N   1 
ATOM   1336 C  CA  . LEU A 1 223 ? -12.198 17.201  -12.770 1.00 20.09 ? 217 LEU A CA  1 
ATOM   1337 C  C   . LEU A 1 223 ? -13.296 18.219  -12.492 1.00 19.98 ? 217 LEU A C   1 
ATOM   1338 O  O   . LEU A 1 223 ? -13.056 19.426  -12.574 1.00 20.46 ? 217 LEU A O   1 
ATOM   1339 C  CB  . LEU A 1 223 ? -12.161 16.842  -14.265 1.00 18.20 ? 217 LEU A CB  1 
ATOM   1340 C  CG  . LEU A 1 223 ? -10.788 16.349  -14.738 1.00 19.04 ? 217 LEU A CG  1 
ATOM   1341 C  CD1 . LEU A 1 223 ? -10.940 15.514  -15.993 1.00 17.80 ? 217 LEU A CD1 1 
ATOM   1342 C  CD2 . LEU A 1 223 ? -9.829  17.521  -14.957 1.00 18.98 ? 217 LEU A CD2 1 
ATOM   1343 N  N   . ALA A 1 224 ? -14.501 17.754  -12.172 1.00 18.55 ? 218 ALA A N   1 
ATOM   1344 C  CA  . ALA A 1 224 ? -15.571 18.652  -11.760 1.00 17.20 ? 218 ALA A CA  1 
ATOM   1345 C  C   . ALA A 1 224 ? -15.342 19.164  -10.340 1.00 19.39 ? 218 ALA A C   1 
ATOM   1346 O  O   . ALA A 1 224 ? -15.444 20.368  -10.080 1.00 18.95 ? 218 ALA A O   1 
ATOM   1347 C  CB  . ALA A 1 224 ? -16.913 17.922  -11.863 1.00 14.67 ? 218 ALA A CB  1 
ATOM   1348 N  N   . LEU A 1 225 ? -15.015 18.256  -9.412  1.00 17.60 ? 219 LEU A N   1 
ATOM   1349 C  CA  . LEU A 1 225 ? -14.933 18.610  -7.998  1.00 19.62 ? 219 LEU A CA  1 
ATOM   1350 C  C   . LEU A 1 225 ? -13.867 19.658  -7.718  1.00 22.30 ? 219 LEU A C   1 
ATOM   1351 O  O   . LEU A 1 225 ? -13.972 20.409  -6.739  1.00 18.50 ? 219 LEU A O   1 
ATOM   1352 C  CB  . LEU A 1 225 ? -14.648 17.360  -7.166  1.00 18.62 ? 219 LEU A CB  1 
ATOM   1353 C  CG  . LEU A 1 225 ? -15.875 16.472  -7.011  1.00 17.48 ? 219 LEU A CG  1 
ATOM   1354 C  CD1 . LEU A 1 225 ? -15.450 15.046  -6.622  1.00 14.48 ? 219 LEU A CD1 1 
ATOM   1355 C  CD2 . LEU A 1 225 ? -16.814 17.088  -5.983  1.00 15.79 ? 219 LEU A CD2 1 
ATOM   1356 N  N   . ARG A 1 226 ? -12.806 19.692  -8.520  1.00 24.01 ? 220 ARG A N   1 
ATOM   1357 C  CA  . ARG A 1 226 ? -11.752 20.650  -8.234  1.00 24.30 ? 220 ARG A CA  1 
ATOM   1358 C  C   . ARG A 1 226 ? -12.211 22.085  -8.440  1.00 24.63 ? 220 ARG A C   1 
ATOM   1359 O  O   . ARG A 1 226 ? -11.504 23.003  -8.022  1.00 22.71 ? 220 ARG A O   1 
ATOM   1360 C  CB  . ARG A 1 226 ? -10.517 20.333  -9.081  1.00 23.11 ? 220 ARG A CB  1 
ATOM   1361 C  CG  . ARG A 1 226 ? -10.716 20.453  -10.555 1.00 26.62 ? 220 ARG A CG  1 
ATOM   1362 C  CD  . ARG A 1 226 ? -9.377  20.328  -11.318 1.00 30.88 ? 220 ARG A CD  1 
ATOM   1363 N  NE  . ARG A 1 226 ? -8.565  21.525  -11.137 1.00 36.67 ? 220 ARG A NE  1 
ATOM   1364 C  CZ  . ARG A 1 226 ? -8.595  22.578  -11.946 1.00 41.11 ? 220 ARG A CZ  1 
ATOM   1365 N  NH1 . ARG A 1 226 ? -9.322  22.581  -13.055 1.00 32.99 ? 220 ARG A NH1 1 
ATOM   1366 N  NH2 . ARG A 1 226 ? -7.877  23.655  -11.632 1.00 37.16 ? 220 ARG A NH2 1 
ATOM   1367 N  N   . HIS A 1 227 ? -13.377 22.300  -9.053  1.00 23.50 ? 221 HIS A N   1 
ATOM   1368 C  CA  . HIS A 1 227 ? -13.949 23.634  -9.153  1.00 26.43 ? 221 HIS A CA  1 
ATOM   1369 C  C   . HIS A 1 227 ? -14.739 24.017  -7.910  1.00 27.10 ? 221 HIS A C   1 
ATOM   1370 O  O   . HIS A 1 227 ? -15.344 25.094  -7.892  1.00 28.65 ? 221 HIS A O   1 
ATOM   1371 C  CB  . HIS A 1 227 ? -14.882 23.740  -10.369 1.00 21.72 ? 221 HIS A CB  1 
ATOM   1372 C  CG  . HIS A 1 227 ? -14.184 23.615  -11.686 1.00 31.26 ? 221 HIS A CG  1 
ATOM   1373 N  ND1 . HIS A 1 227 ? -13.218 24.504  -12.106 1.00 30.05 ? 221 HIS A ND1 1 
ATOM   1374 C  CD2 . HIS A 1 227 ? -14.313 22.702  -12.679 1.00 27.62 ? 221 HIS A CD2 1 
ATOM   1375 C  CE1 . HIS A 1 227 ? -12.783 24.146  -13.299 1.00 32.43 ? 221 HIS A CE1 1 
ATOM   1376 N  NE2 . HIS A 1 227 ? -13.432 23.059  -13.672 1.00 35.27 ? 221 HIS A NE2 1 
ATOM   1377 N  N   . SER A 1 228 ? -14.806 23.153  -6.900  1.00 20.09 ? 222 SER A N   1 
ATOM   1378 C  CA  . SER A 1 228 ? -15.633 23.450  -5.738  1.00 20.35 ? 222 SER A CA  1 
ATOM   1379 C  C   . SER A 1 228 ? -14.769 23.661  -4.504  1.00 24.51 ? 222 SER A C   1 
ATOM   1380 O  O   . SER A 1 228 ? -14.169 22.696  -4.000  1.00 21.53 ? 222 SER A O   1 
ATOM   1381 C  CB  . SER A 1 228 ? -16.642 22.334  -5.497  1.00 23.18 ? 222 SER A CB  1 
ATOM   1382 O  OG  . SER A 1 228 ? -17.275 22.522  -4.248  1.00 25.09 ? 222 SER A OG  1 
ATOM   1383 N  N   . PRO A 1 229 ? -14.681 24.896  -3.985  1.00 27.58 ? 223 PRO A N   1 
ATOM   1384 C  CA  . PRO A 1 229 ? -13.934 25.137  -2.729  1.00 21.66 ? 223 PRO A CA  1 
ATOM   1385 C  C   . PRO A 1 229 ? -14.366 24.253  -1.571  1.00 19.82 ? 223 PRO A C   1 
ATOM   1386 O  O   . PRO A 1 229 ? -13.528 23.880  -0.746  1.00 20.43 ? 223 PRO A O   1 
ATOM   1387 C  CB  . PRO A 1 229 ? -14.220 26.622  -2.428  1.00 23.55 ? 223 PRO A CB  1 
ATOM   1388 C  CG  . PRO A 1 229 ? -14.597 27.224  -3.757  1.00 23.43 ? 223 PRO A CG  1 
ATOM   1389 C  CD  . PRO A 1 229 ? -15.312 26.121  -4.512  1.00 23.58 ? 223 PRO A CD  1 
ATOM   1390 N  N   . ARG A 1 230 ? -15.653 23.919  -1.480  1.00 22.08 ? 224 ARG A N   1 
ATOM   1391 C  CA  . ARG A 1 230 ? -16.166 23.054  -0.418  1.00 23.89 ? 224 ARG A CA  1 
ATOM   1392 C  C   . ARG A 1 230 ? -15.550 21.652  -0.444  1.00 25.60 ? 224 ARG A C   1 
ATOM   1393 O  O   . ARG A 1 230 ? -15.552 20.957  0.584   1.00 23.43 ? 224 ARG A O   1 
ATOM   1394 C  CB  . ARG A 1 230 ? -17.683 22.928  -0.571  1.00 22.41 ? 224 ARG A CB  1 
ATOM   1395 C  CG  . ARG A 1 230 ? -18.460 23.669  0.446   1.00 27.15 ? 224 ARG A CG  1 
ATOM   1396 C  CD  . ARG A 1 230 ? -19.826 24.104  -0.097  1.00 36.61 ? 224 ARG A CD  1 
ATOM   1397 N  NE  . ARG A 1 230 ? -20.705 22.986  -0.416  1.00 32.10 ? 224 ARG A NE  1 
ATOM   1398 C  CZ  . ARG A 1 230 ? -21.408 22.876  -1.534  1.00 33.76 ? 224 ARG A CZ  1 
ATOM   1399 N  NH1 . ARG A 1 230 ? -21.370 23.808  -2.473  1.00 34.48 ? 224 ARG A NH1 1 
ATOM   1400 N  NH2 . ARG A 1 230 ? -22.171 21.802  -1.715  1.00 40.06 ? 224 ARG A NH2 1 
ATOM   1401 N  N   . HIS A 1 231 ? -15.054 21.209  -1.598  1.00 21.33 ? 225 HIS A N   1 
ATOM   1402 C  CA  . HIS A 1 231 ? -14.595 19.836  -1.761  1.00 25.87 ? 225 HIS A CA  1 
ATOM   1403 C  C   . HIS A 1 231 ? -13.091 19.699  -1.926  1.00 22.71 ? 225 HIS A C   1 
ATOM   1404 O  O   . HIS A 1 231 ? -12.590 18.575  -1.869  1.00 25.84 ? 225 HIS A O   1 
ATOM   1405 C  CB  . HIS A 1 231 ? -15.300 19.189  -2.963  1.00 21.96 ? 225 HIS A CB  1 
ATOM   1406 C  CG  . HIS A 1 231 ? -16.784 19.099  -2.800  1.00 21.84 ? 225 HIS A CG  1 
ATOM   1407 N  ND1 . HIS A 1 231 ? -17.642 20.081  -3.243  1.00 20.93 ? 225 HIS A ND1 1 
ATOM   1408 C  CD2 . HIS A 1 231 ? -17.559 18.157  -2.210  1.00 21.17 ? 225 HIS A CD2 1 
ATOM   1409 C  CE1 . HIS A 1 231 ? -18.885 19.734  -2.962  1.00 23.07 ? 225 HIS A CE1 1 
ATOM   1410 N  NE2 . HIS A 1 231 ? -18.862 18.575  -2.326  1.00 20.44 ? 225 HIS A NE2 1 
ATOM   1411 N  N   . ARG A 1 232 ? -12.357 20.806  -2.076  1.00 25.78 ? 226 ARG A N   1 
ATOM   1412 C  CA  . ARG A 1 232 ? -10.921 20.782  -2.336  1.00 28.81 ? 226 ARG A CA  1 
ATOM   1413 C  C   . ARG A 1 232 ? -10.069 20.208  -1.202  1.00 26.07 ? 226 ARG A C   1 
ATOM   1414 O  O   . ARG A 1 232 ? -8.978  19.682  -1.477  1.00 23.54 ? 226 ARG A O   1 
ATOM   1415 C  CB  . ARG A 1 232 ? -10.448 22.194  -2.705  1.00 27.95 ? 226 ARG A CB  1 
ATOM   1416 C  CG  . ARG A 1 232 ? -10.957 22.618  -4.107  1.00 30.93 ? 226 ARG A CG  1 
ATOM   1417 C  CD  . ARG A 1 232 ? -10.233 23.855  -4.651  1.00 29.51 ? 226 ARG A CD  1 
ATOM   1418 N  NE  . ARG A 1 232 ? -8.801  23.601  -4.731  1.00 33.85 ? 226 ARG A NE  1 
ATOM   1419 C  CZ  . ARG A 1 232 ? -8.205  22.970  -5.735  1.00 32.37 ? 226 ARG A CZ  1 
ATOM   1420 N  NH1 . ARG A 1 232 ? -8.874  22.613  -6.824  1.00 30.56 ? 226 ARG A NH1 1 
ATOM   1421 N  NH2 . ARG A 1 232 ? -6.909  22.682  -5.641  1.00 27.87 ? 226 ARG A NH2 1 
ATOM   1422 N  N   . PRO A 1 233 ? -10.499 20.253  0.066   1.00 26.86 ? 227 PRO A N   1 
ATOM   1423 C  CA  . PRO A 1 233 ? -9.670  19.627  1.114   1.00 23.26 ? 227 PRO A CA  1 
ATOM   1424 C  C   . PRO A 1 233 ? -9.423  18.136  0.901   1.00 24.91 ? 227 PRO A C   1 
ATOM   1425 O  O   . PRO A 1 233 ? -8.359  17.631  1.293   1.00 24.18 ? 227 PRO A O   1 
ATOM   1426 C  CB  . PRO A 1 233 ? -10.474 19.894  2.395   1.00 29.02 ? 227 PRO A CB  1 
ATOM   1427 C  CG  . PRO A 1 233 ? -11.229 21.176  2.084   1.00 27.76 ? 227 PRO A CG  1 
ATOM   1428 C  CD  . PRO A 1 233 ? -11.645 20.974  0.650   1.00 23.67 ? 227 PRO A CD  1 
ATOM   1429 N  N   . ALA A 1 234 ? -10.365 17.407  0.301   1.00 22.86 ? 228 ALA A N   1 
ATOM   1430 C  CA  . ALA A 1 234 ? -10.185 15.970  0.109   1.00 22.47 ? 228 ALA A CA  1 
ATOM   1431 C  C   . ALA A 1 234 ? -9.399  15.635  -1.151  1.00 25.28 ? 228 ALA A C   1 
ATOM   1432 O  O   . ALA A 1 234 ? -9.106  14.457  -1.385  1.00 25.76 ? 228 ALA A O   1 
ATOM   1433 C  CB  . ALA A 1 234 ? -11.536 15.256  0.062   1.00 16.31 ? 228 ALA A CB  1 
ATOM   1434 N  N   . LEU A 1 235 ? -9.028  16.639  -1.945  1.00 20.66 ? 229 LEU A N   1 
ATOM   1435 C  CA  . LEU A 1 235 ? -8.510  16.371  -3.287  1.00 27.09 ? 229 LEU A CA  1 
ATOM   1436 C  C   . LEU A 1 235 ? -7.071  15.870  -3.246  1.00 30.41 ? 229 LEU A C   1 
ATOM   1437 O  O   . LEU A 1 235 ? -6.712  14.925  -3.967  1.00 28.63 ? 229 LEU A O   1 
ATOM   1438 C  CB  . LEU A 1 235 ? -8.608  17.635  -4.130  1.00 22.40 ? 229 LEU A CB  1 
ATOM   1439 C  CG  . LEU A 1 235 ? -8.677  17.582  -5.650  1.00 32.06 ? 229 LEU A CG  1 
ATOM   1440 C  CD1 . LEU A 1 235 ? -9.640  16.512  -6.163  1.00 27.50 ? 229 LEU A CD1 1 
ATOM   1441 C  CD2 . LEU A 1 235 ? -9.053  18.980  -6.144  1.00 30.27 ? 229 LEU A CD2 1 
ATOM   1442 N  N   . GLY A 1 236 ? -6.235  16.487  -2.409  1.00 26.67 ? 230 GLY A N   1 
ATOM   1443 C  CA  . GLY A 1 236 ? -4.828  16.127  -2.377  1.00 28.25 ? 230 GLY A CA  1 
ATOM   1444 C  C   . GLY A 1 236 ? -4.605  14.636  -2.255  1.00 28.92 ? 230 GLY A C   1 
ATOM   1445 O  O   . GLY A 1 236 ? -3.799  14.060  -2.983  1.00 28.96 ? 230 GLY A O   1 
ATOM   1446 N  N   . ASP A 1 237 ? -5.335  13.989  -1.337  1.00 31.76 ? 231 ASP A N   1 
ATOM   1447 C  CA  . ASP A 1 237 ? -5.125  12.572  -1.043  1.00 29.70 ? 231 ASP A CA  1 
ATOM   1448 C  C   . ASP A 1 237 ? -5.513  11.678  -2.215  1.00 31.02 ? 231 ASP A C   1 
ATOM   1449 O  O   . ASP A 1 237 ? -4.847  10.667  -2.475  1.00 28.72 ? 231 ASP A O   1 
ATOM   1450 C  CB  . ASP A 1 237 ? -5.940  12.162  0.188   1.00 38.83 ? 231 ASP A CB  1 
ATOM   1451 C  CG  . ASP A 1 237 ? -5.253  12.498  1.496   1.00 49.95 ? 231 ASP A CG  1 
ATOM   1452 O  OD1 . ASP A 1 237 ? -4.004  12.628  1.506   1.00 48.57 ? 231 ASP A OD1 1 
ATOM   1453 O  OD2 . ASP A 1 237 ? -5.977  12.623  2.521   1.00 53.77 ? 231 ASP A OD2 1 
ATOM   1454 N  N   . VAL A 1 238 ? -6.610  11.988  -2.909  1.00 26.25 ? 232 VAL A N   1 
ATOM   1455 C  CA  . VAL A 1 238 ? -7.002  11.108  -4.006  1.00 32.32 ? 232 VAL A CA  1 
ATOM   1456 C  C   . VAL A 1 238 ? -6.041  11.262  -5.181  1.00 26.16 ? 232 VAL A C   1 
ATOM   1457 O  O   . VAL A 1 238 ? -5.682  10.278  -5.838  1.00 27.87 ? 232 VAL A O   1 
ATOM   1458 C  CB  . VAL A 1 238 ? -8.469  11.346  -4.422  1.00 26.57 ? 232 VAL A CB  1 
ATOM   1459 C  CG1 . VAL A 1 238 ? -9.390  11.165  -3.234  1.00 26.30 ? 232 VAL A CG1 1 
ATOM   1460 C  CG2 . VAL A 1 238 ? -8.638  12.706  -5.013  1.00 29.68 ? 232 VAL A CG2 1 
ATOM   1461 N  N   . LEU A 1 239 ? -5.591  12.488  -5.453  1.00 25.95 ? 233 LEU A N   1 
ATOM   1462 C  CA  . LEU A 1 239 ? -4.605  12.690  -6.508  1.00 25.58 ? 233 LEU A CA  1 
ATOM   1463 C  C   . LEU A 1 239 ? -3.373  11.814  -6.306  1.00 28.73 ? 233 LEU A C   1 
ATOM   1464 O  O   . LEU A 1 239 ? -2.709  11.444  -7.282  1.00 27.86 ? 233 LEU A O   1 
ATOM   1465 C  CB  . LEU A 1 239 ? -4.194  14.153  -6.574  1.00 25.61 ? 233 LEU A CB  1 
ATOM   1466 C  CG  . LEU A 1 239 ? -5.264  15.125  -7.090  1.00 29.98 ? 233 LEU A CG  1 
ATOM   1467 C  CD1 . LEU A 1 239 ? -4.610  16.406  -7.584  1.00 27.21 ? 233 LEU A CD1 1 
ATOM   1468 C  CD2 . LEU A 1 239 ? -6.112  14.486  -8.194  1.00 28.98 ? 233 LEU A CD2 1 
ATOM   1469 N  N   . LYS A 1 240 ? -3.047  11.472  -5.059  1.00 28.29 ? 234 LYS A N   1 
ATOM   1470 C  CA  . LYS A 1 240 ? -1.904  10.592  -4.827  1.00 30.35 ? 234 LYS A CA  1 
ATOM   1471 C  C   . LYS A 1 240 ? -2.249  9.157   -5.186  1.00 28.23 ? 234 LYS A C   1 
ATOM   1472 O  O   . LYS A 1 240 ? -1.427  8.443   -5.768  1.00 27.36 ? 234 LYS A O   1 
ATOM   1473 C  CB  . LYS A 1 240 ? -1.447  10.669  -3.370  1.00 30.89 ? 234 LYS A CB  1 
ATOM   1474 C  CG  . LYS A 1 240 ? -0.991  12.046  -2.930  1.00 32.61 ? 234 LYS A CG  1 
ATOM   1475 C  CD  . LYS A 1 240 ? -0.110  11.965  -1.672  1.00 40.19 ? 234 LYS A CD  1 
ATOM   1476 C  CE  . LYS A 1 240 ? 0.330   13.362  -1.193  1.00 43.93 ? 234 LYS A CE  1 
ATOM   1477 N  NZ  . LYS A 1 240 ? -0.340  13.759  0.076   1.00 42.82 ? 234 LYS A NZ  1 
ATOM   1478 N  N   . HIS A 1 241 ? -3.458  8.707   -4.841  1.00 27.86 ? 235 HIS A N   1 
ATOM   1479 C  CA  . HIS A 1 241 ? -3.807  7.355   -5.230  1.00 28.70 ? 235 HIS A CA  1 
ATOM   1480 C  C   . HIS A 1 241 ? -4.016  7.260   -6.737  1.00 28.49 ? 235 HIS A C   1 
ATOM   1481 O  O   . HIS A 1 241 ? -3.677  6.242   -7.351  1.00 29.83 ? 235 HIS A O   1 
ATOM   1482 C  CB  . HIS A 1 241 ? -5.036  6.847   -4.497  1.00 26.26 ? 235 HIS A CB  1 
ATOM   1483 C  CG  . HIS A 1 241 ? -5.274  5.395   -4.764  1.00 39.71 ? 235 HIS A CG  1 
ATOM   1484 N  ND1 . HIS A 1 241 ? -4.948  4.403   -3.862  1.00 42.50 ? 235 HIS A ND1 1 
ATOM   1485 C  CD2 . HIS A 1 241 ? -5.707  4.760   -5.883  1.00 34.89 ? 235 HIS A CD2 1 
ATOM   1486 C  CE1 . HIS A 1 241 ? -5.215  3.223   -4.401  1.00 37.47 ? 235 HIS A CE1 1 
ATOM   1487 N  NE2 . HIS A 1 241 ? -5.671  3.413   -5.628  1.00 32.93 ? 235 HIS A NE2 1 
ATOM   1488 N  N   . VAL A 1 242 ? -4.576  8.304   -7.351  1.00 24.99 ? 236 VAL A N   1 
ATOM   1489 C  CA  . VAL A 1 242 ? -4.722  8.303   -8.804  1.00 26.00 ? 236 VAL A CA  1 
ATOM   1490 C  C   . VAL A 1 242 ? -3.359  8.139   -9.458  1.00 26.51 ? 236 VAL A C   1 
ATOM   1491 O  O   . VAL A 1 242 ? -3.171  7.296   -10.336 1.00 25.11 ? 236 VAL A O   1 
ATOM   1492 C  CB  . VAL A 1 242 ? -5.417  9.592   -9.285  1.00 26.64 ? 236 VAL A CB  1 
ATOM   1493 C  CG1 . VAL A 1 242 ? -5.179  9.794   -10.759 1.00 23.83 ? 236 VAL A CG1 1 
ATOM   1494 C  CG2 . VAL A 1 242 ? -6.906  9.555   -8.983  1.00 25.70 ? 236 VAL A CG2 1 
ATOM   1495 N  N   . ALA A 1 243 ? -2.382  8.950   -9.034  1.00 27.60 ? 237 ALA A N   1 
ATOM   1496 C  CA  . ALA A 1 243 ? -1.063  8.911   -9.663  1.00 31.58 ? 237 ALA A CA  1 
ATOM   1497 C  C   . ALA A 1 243 ? -0.397  7.558   -9.488  1.00 27.80 ? 237 ALA A C   1 
ATOM   1498 O  O   . ALA A 1 243 ? 0.384   7.144   -10.350 1.00 27.61 ? 237 ALA A O   1 
ATOM   1499 C  CB  . ALA A 1 243 ? -0.166  10.016  -9.095  1.00 29.10 ? 237 ALA A CB  1 
ATOM   1500 N  N   . GLY A 1 244 ? -0.691  6.860   -8.387  1.00 26.27 ? 238 GLY A N   1 
ATOM   1501 C  CA  . GLY A 1 244 ? -0.174  5.538   -8.101  1.00 28.01 ? 238 GLY A CA  1 
ATOM   1502 C  C   . GLY A 1 244 ? -0.786  4.415   -8.909  1.00 30.66 ? 238 GLY A C   1 
ATOM   1503 O  O   . GLY A 1 244 ? -0.393  3.253   -8.745  1.00 29.56 ? 238 GLY A O   1 
ATOM   1504 N  N   . ARG A 1 245 ? -1.748  4.718   -9.780  1.00 24.99 ? 239 ARG A N   1 
ATOM   1505 C  CA  . ARG A 1 245 ? -2.388  3.674   -10.576 1.00 30.33 ? 239 ARG A CA  1 
ATOM   1506 C  C   . ARG A 1 245 ? -1.703  3.427   -11.917 1.00 26.00 ? 239 ARG A C   1 
ATOM   1507 O  O   . ARG A 1 245 ? -2.049  2.461   -12.594 1.00 27.72 ? 239 ARG A O   1 
ATOM   1508 C  CB  . ARG A 1 245 ? -3.860  4.020   -10.827 1.00 27.26 ? 239 ARG A CB  1 
ATOM   1509 C  CG  . ARG A 1 245 ? -4.776  3.755   -9.672  1.00 23.41 ? 239 ARG A CG  1 
ATOM   1510 C  CD  . ARG A 1 245 ? -6.134  4.382   -9.916  1.00 23.94 ? 239 ARG A CD  1 
ATOM   1511 N  NE  . ARG A 1 245 ? -6.702  4.837   -8.656  1.00 24.94 ? 239 ARG A NE  1 
ATOM   1512 C  CZ  . ARG A 1 245 ? -7.780  5.595   -8.530  1.00 26.14 ? 239 ARG A CZ  1 
ATOM   1513 N  NH1 . ARG A 1 245 ? -8.448  6.033   -9.587  1.00 22.17 ? 239 ARG A NH1 1 
ATOM   1514 N  NH2 . ARG A 1 245 ? -8.193  5.932   -7.311  1.00 25.05 ? 239 ARG A NH2 1 
ATOM   1515 N  N   . LEU A 1 246 ? -0.762  4.275   -12.321 1.00 28.51 ? 240 LEU A N   1 
ATOM   1516 C  CA  . LEU A 1 246 ? -0.149  4.142   -13.634 1.00 26.59 ? 240 LEU A CA  1 
ATOM   1517 C  C   . LEU A 1 246 ? 0.373   2.731   -13.834 1.00 32.20 ? 240 LEU A C   1 
ATOM   1518 O  O   . LEU A 1 246 ? 0.858   2.088   -12.899 1.00 32.09 ? 240 LEU A O   1 
ATOM   1519 C  CB  . LEU A 1 246 ? 0.999   5.131   -13.798 1.00 27.29 ? 240 LEU A CB  1 
ATOM   1520 C  CG  . LEU A 1 246 ? 0.642   6.606   -13.693 1.00 28.06 ? 240 LEU A CG  1 
ATOM   1521 C  CD1 . LEU A 1 246 ? 1.731   7.410   -14.377 1.00 29.79 ? 240 LEU A CD1 1 
ATOM   1522 C  CD2 . LEU A 1 246 ? -0.703  6.862   -14.338 1.00 26.38 ? 240 LEU A CD2 1 
ATOM   1523 N  N   . ARG A 1 247 ? 0.260   2.245   -15.057 1.00 34.18 ? 241 ARG A N   1 
ATOM   1524 C  CA  . ARG A 1 247 ? 0.760   0.921   -15.381 1.00 34.80 ? 241 ARG A CA  1 
ATOM   1525 C  C   . ARG A 1 247 ? 2.209   1.016   -15.825 1.00 33.81 ? 241 ARG A C   1 
ATOM   1526 O  O   . ARG A 1 247 ? 2.728   2.111   -16.084 1.00 32.63 ? 241 ARG A O   1 
ATOM   1527 C  CB  . ARG A 1 247 ? -0.117  0.289   -16.455 1.00 27.26 ? 241 ARG A CB  1 
ATOM   1528 C  CG  . ARG A 1 247 ? -1.461  -0.175  -15.908 1.00 31.24 ? 241 ARG A CG  1 
ATOM   1529 C  CD  . ARG A 1 247 ? -2.273  -0.839  -17.004 1.00 30.70 ? 241 ARG A CD  1 
ATOM   1530 N  NE  . ARG A 1 247 ? -1.583  -1.969  -17.626 1.00 31.15 ? 241 ARG A NE  1 
ATOM   1531 C  CZ  . ARG A 1 247 ? -1.571  -3.193  -17.120 1.00 31.57 ? 241 ARG A CZ  1 
ATOM   1532 N  NH1 . ARG A 1 247 ? -2.139  -3.459  -15.961 1.00 32.75 ? 241 ARG A NH1 1 
ATOM   1533 N  NH2 . ARG A 1 247 ? -0.981  -4.176  -17.798 1.00 35.95 ? 241 ARG A NH2 1 
ATOM   1534 N  N   . PRO A 1 248 ? 2.898   -0.123  -15.908 1.00 31.30 ? 242 PRO A N   1 
ATOM   1535 C  CA  . PRO A 1 248 ? 4.315   -0.095  -16.302 1.00 35.16 ? 242 PRO A CA  1 
ATOM   1536 C  C   . PRO A 1 248 ? 4.584   0.763   -17.521 1.00 34.40 ? 242 PRO A C   1 
ATOM   1537 O  O   . PRO A 1 248 ? 5.632   1.417   -17.575 1.00 39.80 ? 242 PRO A O   1 
ATOM   1538 C  CB  . PRO A 1 248 ? 4.631   -1.575  -16.556 1.00 37.26 ? 242 PRO A CB  1 
ATOM   1539 C  CG  . PRO A 1 248 ? 3.688   -2.305  -15.634 1.00 31.51 ? 242 PRO A CG  1 
ATOM   1540 C  CD  . PRO A 1 248 ? 2.421   -1.488  -15.622 1.00 27.23 ? 242 PRO A CD  1 
ATOM   1541 N  N   . ASP A 1 249 ? 3.659   0.830   -18.477 1.00 30.22 ? 243 ASP A N   1 
ATOM   1542 C  CA  . ASP A 1 249 ? 3.870   1.639   -19.670 1.00 33.24 ? 243 ASP A CA  1 
ATOM   1543 C  C   . ASP A 1 249 ? 3.494   3.110   -19.495 1.00 30.48 ? 243 ASP A C   1 
ATOM   1544 O  O   . ASP A 1 249 ? 3.558   3.859   -20.471 1.00 30.82 ? 243 ASP A O   1 
ATOM   1545 C  CB  . ASP A 1 249 ? 3.107   1.047   -20.862 1.00 27.62 ? 243 ASP A CB  1 
ATOM   1546 C  CG  . ASP A 1 249 ? 1.595   1.034   -20.658 1.00 34.99 ? 243 ASP A CG  1 
ATOM   1547 O  OD1 . ASP A 1 249 ? 1.127   1.478   -19.584 1.00 33.25 ? 243 ASP A OD1 1 
ATOM   1548 O  OD2 . ASP A 1 249 ? 0.878   0.572   -21.580 1.00 33.27 ? 243 ASP A OD2 1 
ATOM   1549 N  N   . GLY A 1 250 ? 3.121   3.547   -18.296 1.00 29.80 ? 244 GLY A N   1 
ATOM   1550 C  CA  . GLY A 1 250 ? 2.886   4.960   -18.051 1.00 28.88 ? 244 GLY A CA  1 
ATOM   1551 C  C   . GLY A 1 250 ? 1.468   5.432   -18.251 1.00 29.43 ? 244 GLY A C   1 
ATOM   1552 O  O   . GLY A 1 250 ? 1.210   6.641   -18.133 1.00 27.03 ? 244 GLY A O   1 
ATOM   1553 N  N   . GLY A 1 251 ? 0.533   4.525   -18.538 1.00 24.99 ? 245 GLY A N   1 
ATOM   1554 C  CA  . GLY A 1 251 ? -0.839  4.891   -18.799 1.00 25.05 ? 245 GLY A CA  1 
ATOM   1555 C  C   . GLY A 1 251 ? -1.781  4.535   -17.656 1.00 22.58 ? 245 GLY A C   1 
ATOM   1556 O  O   . GLY A 1 251 ? -1.430  3.852   -16.689 1.00 21.27 ? 245 GLY A O   1 
ATOM   1557 N  N   . MET A 1 252 ? -3.012  5.021   -17.804 1.00 19.07 ? 246 MET A N   1 
ATOM   1558 C  CA  . MET A 1 252 ? -4.108  4.801   -16.872 1.00 20.22 ? 246 MET A CA  1 
ATOM   1559 C  C   . MET A 1 252 ? -5.117  3.844   -17.495 1.00 20.60 ? 246 MET A C   1 
ATOM   1560 O  O   . MET A 1 252 ? -5.634  4.121   -18.587 1.00 20.51 ? 246 MET A O   1 
ATOM   1561 C  CB  . MET A 1 252 ? -4.784  6.127   -16.513 1.00 18.63 ? 246 MET A CB  1 
ATOM   1562 C  CG  . MET A 1 252 ? -5.947  5.989   -15.543 1.00 20.18 ? 246 MET A CG  1 
ATOM   1563 S  SD  . MET A 1 252 ? -5.372  5.557   -13.888 1.00 28.02 ? 246 MET A SD  1 
ATOM   1564 C  CE  . MET A 1 252 ? -4.679  7.178   -13.456 1.00 22.40 ? 246 MET A CE  1 
ATOM   1565 N  N   . PRO A 1 253 ? -5.430  2.720   -16.862 1.00 21.92 ? 247 PRO A N   1 
ATOM   1566 C  CA  . PRO A 1 253 ? -6.452  1.823   -17.410 1.00 20.43 ? 247 PRO A CA  1 
ATOM   1567 C  C   . PRO A 1 253 ? -7.854  2.366   -17.173 1.00 23.18 ? 247 PRO A C   1 
ATOM   1568 O  O   . PRO A 1 253 ? -8.107  3.173   -16.272 1.00 22.05 ? 247 PRO A O   1 
ATOM   1569 C  CB  . PRO A 1 253 ? -6.239  0.517   -16.632 1.00 22.93 ? 247 PRO A CB  1 
ATOM   1570 C  CG  . PRO A 1 253 ? -5.697  0.976   -15.289 1.00 22.46 ? 247 PRO A CG  1 
ATOM   1571 C  CD  . PRO A 1 253 ? -4.859  2.221   -15.593 1.00 19.84 ? 247 PRO A CD  1 
ATOM   1572 N  N   . TYR A 1 254 ? -8.779  1.890   -18.003 1.00 21.47 ? 248 TYR A N   1 
ATOM   1573 C  CA  . TYR A 1 254 ? -10.179 2.271   -17.840 1.00 20.85 ? 248 TYR A CA  1 
ATOM   1574 C  C   . TYR A 1 254 ? -10.724 1.796   -16.495 1.00 18.31 ? 248 TYR A C   1 
ATOM   1575 O  O   . TYR A 1 254 ? -11.300 2.580   -15.728 1.00 19.38 ? 248 TYR A O   1 
ATOM   1576 C  CB  . TYR A 1 254 ? -10.990 1.695   -19.002 1.00 19.13 ? 248 TYR A CB  1 
ATOM   1577 C  CG  . TYR A 1 254 ? -12.490 1.778   -18.856 1.00 20.91 ? 248 TYR A CG  1 
ATOM   1578 C  CD1 . TYR A 1 254 ? -13.109 2.907   -18.325 1.00 23.19 ? 248 TYR A CD1 1 
ATOM   1579 C  CD2 . TYR A 1 254 ? -13.290 0.750   -19.303 1.00 18.41 ? 248 TYR A CD2 1 
ATOM   1580 C  CE1 . TYR A 1 254 ? -14.488 2.976   -18.232 1.00 24.66 ? 248 TYR A CE1 1 
ATOM   1581 C  CE2 . TYR A 1 254 ? -14.642 0.807   -19.207 1.00 20.39 ? 248 TYR A CE2 1 
ATOM   1582 C  CZ  . TYR A 1 254 ? -15.247 1.915   -18.683 1.00 24.71 ? 248 TYR A CZ  1 
ATOM   1583 O  OH  . TYR A 1 254 ? -16.629 1.927   -18.606 1.00 29.43 ? 248 TYR A OH  1 
ATOM   1584 N  N   . ILE A 1 255 ? -10.543 0.512   -16.189 1.00 19.95 ? 249 ILE A N   1 
ATOM   1585 C  CA  . ILE A 1 255 ? -11.056 -0.123  -14.982 1.00 17.05 ? 249 ILE A CA  1 
ATOM   1586 C  C   . ILE A 1 255 ? -9.910  -0.899  -14.338 1.00 20.56 ? 249 ILE A C   1 
ATOM   1587 O  O   . ILE A 1 255 ? -8.878  -1.143  -14.962 1.00 22.75 ? 249 ILE A O   1 
ATOM   1588 C  CB  . ILE A 1 255 ? -12.250 -1.051  -15.293 1.00 20.12 ? 249 ILE A CB  1 
ATOM   1589 C  CG1 . ILE A 1 255 ? -11.856 -2.065  -16.379 1.00 18.37 ? 249 ILE A CG1 1 
ATOM   1590 C  CG2 . ILE A 1 255 ? -13.441 -0.232  -15.782 1.00 18.58 ? 249 ILE A CG2 1 
ATOM   1591 C  CD1 . ILE A 1 255 ? -13.027 -2.895  -16.896 1.00 22.65 ? 249 ILE A CD1 1 
ATOM   1592 N  N   . ASP A 1 256 ? -10.099 -1.292  -13.067 1.00 19.90 ? 250 ASP A N   1 
ATOM   1593 C  CA  . ASP A 1 256 ? -9.080  -2.106  -12.404 1.00 22.44 ? 250 ASP A CA  1 
ATOM   1594 C  C   . ASP A 1 256 ? -8.861  -3.419  -13.142 1.00 26.36 ? 250 ASP A C   1 
ATOM   1595 O  O   . ASP A 1 256 ? -7.721  -3.853  -13.335 1.00 29.33 ? 250 ASP A O   1 
ATOM   1596 C  CB  . ASP A 1 256 ? -9.473  -2.417  -10.961 1.00 25.44 ? 250 ASP A CB  1 
ATOM   1597 C  CG  . ASP A 1 256 ? -9.395  -1.211  -10.058 1.00 31.73 ? 250 ASP A CG  1 
ATOM   1598 O  OD1 . ASP A 1 256 ? -9.145  -0.099  -10.558 1.00 28.44 ? 250 ASP A OD1 1 
ATOM   1599 O  OD2 . ASP A 1 256 ? -9.594  -1.383  -8.838  1.00 40.62 ? 250 ASP A OD2 1 
ATOM   1600 N  N   . GLY A 1 257 ? -9.944  -4.072  -13.548 1.00 23.86 ? 251 GLY A N   1 
ATOM   1601 C  CA  . GLY A 1 257 ? -9.852  -5.373  -14.172 1.00 22.92 ? 251 GLY A CA  1 
ATOM   1602 C  C   . GLY A 1 257 ? -11.236 -5.975  -14.313 1.00 21.02 ? 251 GLY A C   1 
ATOM   1603 O  O   . GLY A 1 257 ? -12.245 -5.330  -14.021 1.00 22.40 ? 251 GLY A O   1 
ATOM   1604 N  N   . MET A 1 258 ? -11.263 -7.215  -14.782 1.00 21.84 ? 252 MET A N   1 
ATOM   1605 C  CA  . MET A 1 258 ? -12.518 -7.909  -15.034 1.00 17.21 ? 252 MET A CA  1 
ATOM   1606 C  C   . MET A 1 258 ? -12.444 -9.336  -14.508 1.00 17.91 ? 252 MET A C   1 
ATOM   1607 O  O   . MET A 1 258 ? -12.872 -10.286 -15.168 1.00 18.35 ? 252 MET A O   1 
ATOM   1608 C  CB  . MET A 1 258 ? -12.862 -7.907  -16.522 1.00 19.58 ? 252 MET A CB  1 
ATOM   1609 C  CG  . MET A 1 258 ? -13.852 -6.845  -16.946 1.00 17.93 ? 252 MET A CG  1 
ATOM   1610 S  SD  . MET A 1 258 ? -14.103 -6.933  -18.736 1.00 29.07 ? 252 MET A SD  1 
ATOM   1611 C  CE  . MET A 1 258 ? -15.781 -7.578  -18.715 1.00 20.79 ? 252 MET A CE  1 
ATOM   1612 N  N   . THR A 1 259 ? -11.894 -9.507  -13.298 1.00 16.24 ? 253 THR A N   1 
ATOM   1613 C  CA  . THR A 1 259 ? -11.584 -10.858 -12.835 1.00 17.56 ? 253 THR A CA  1 
ATOM   1614 C  C   . THR A 1 259 ? -12.837 -11.704 -12.629 1.00 19.29 ? 253 THR A C   1 
ATOM   1615 O  O   . THR A 1 259 ? -12.792 -12.925 -12.832 1.00 18.99 ? 253 THR A O   1 
ATOM   1616 C  CB  . THR A 1 259 ? -10.770 -10.813 -11.536 1.00 20.17 ? 253 THR A CB  1 
ATOM   1617 O  OG1 . THR A 1 259 ? -10.285 -12.128 -11.227 1.00 20.95 ? 253 THR A OG1 1 
ATOM   1618 C  CG2 . THR A 1 259 ? -11.631 -10.346 -10.387 1.00 20.28 ? 253 THR A CG2 1 
ATOM   1619 N  N   . VAL A 1 260 ? -13.959 -11.106 -12.220 1.00 14.78 ? 254 VAL A N   1 
ATOM   1620 C  CA  . VAL A 1 260 ? -15.143 -11.934 -12.007 1.00 16.93 ? 254 VAL A CA  1 
ATOM   1621 C  C   . VAL A 1 260 ? -15.664 -12.466 -13.342 1.00 17.76 ? 254 VAL A C   1 
ATOM   1622 O  O   . VAL A 1 260 ? -15.844 -13.677 -13.521 1.00 17.54 ? 254 VAL A O   1 
ATOM   1623 C  CB  . VAL A 1 260 ? -16.231 -11.170 -11.233 1.00 14.33 ? 254 VAL A CB  1 
ATOM   1624 C  CG1 . VAL A 1 260 ? -17.520 -12.009 -11.211 1.00 15.80 ? 254 VAL A CG1 1 
ATOM   1625 C  CG2 . VAL A 1 260 ? -15.751 -10.849 -9.786  1.00 19.59 ? 254 VAL A CG2 1 
ATOM   1626 N  N   . PHE A 1 261 ? -15.919 -11.567 -14.291 1.00 16.70 ? 255 PHE A N   1 
ATOM   1627 C  CA  . PHE A 1 261 ? -16.305 -11.960 -15.645 1.00 17.69 ? 255 PHE A CA  1 
ATOM   1628 C  C   . PHE A 1 261 ? -15.351 -13.004 -16.226 1.00 18.55 ? 255 PHE A C   1 
ATOM   1629 O  O   . PHE A 1 261 ? -15.784 -14.042 -16.742 1.00 17.35 ? 255 PHE A O   1 
ATOM   1630 C  CB  . PHE A 1 261 ? -16.342 -10.710 -16.528 1.00 18.77 ? 255 PHE A CB  1 
ATOM   1631 C  CG  . PHE A 1 261 ? -16.729 -10.974 -17.955 1.00 22.33 ? 255 PHE A CG  1 
ATOM   1632 C  CD1 . PHE A 1 261 ? -18.010 -11.393 -18.268 1.00 22.70 ? 255 PHE A CD1 1 
ATOM   1633 C  CD2 . PHE A 1 261 ? -15.820 -10.778 -18.985 1.00 22.45 ? 255 PHE A CD2 1 
ATOM   1634 C  CE1 . PHE A 1 261 ? -18.377 -11.641 -19.577 1.00 29.41 ? 255 PHE A CE1 1 
ATOM   1635 C  CE2 . PHE A 1 261 ? -16.185 -11.006 -20.306 1.00 25.33 ? 255 PHE A CE2 1 
ATOM   1636 C  CZ  . PHE A 1 261 ? -17.462 -11.439 -20.601 1.00 27.69 ? 255 PHE A CZ  1 
ATOM   1637 N  N   . THR A 1 262 ? -14.040 -12.724 -16.172 1.00 18.41 ? 256 THR A N   1 
ATOM   1638 C  CA  . THR A 1 262 ? -13.033 -13.592 -16.789 1.00 13.28 ? 256 THR A CA  1 
ATOM   1639 C  C   . THR A 1 262 ? -12.947 -14.949 -16.091 1.00 16.89 ? 256 THR A C   1 
ATOM   1640 O  O   . THR A 1 262 ? -12.858 -15.988 -16.754 1.00 14.35 ? 256 THR A O   1 
ATOM   1641 C  CB  . THR A 1 262 ? -11.673 -12.893 -16.761 1.00 15.79 ? 256 THR A CB  1 
ATOM   1642 O  OG1 . THR A 1 262 ? -11.766 -11.625 -17.440 1.00 16.82 ? 256 THR A OG1 1 
ATOM   1643 C  CG2 . THR A 1 262 ? -10.588 -13.746 -17.430 1.00 19.97 ? 256 THR A CG2 1 
ATOM   1644 N  N   . THR A 1 263 ? -12.970 -14.965 -14.754 1.00 14.11 ? 257 THR A N   1 
ATOM   1645 C  CA  . THR A 1 263 ? -12.945 -16.237 -14.039 1.00 16.77 ? 257 THR A CA  1 
ATOM   1646 C  C   . THR A 1 263 ? -14.199 -17.052 -14.329 1.00 17.58 ? 257 THR A C   1 
ATOM   1647 O  O   . THR A 1 263 ? -14.129 -18.278 -14.473 1.00 14.41 ? 257 THR A O   1 
ATOM   1648 C  CB  . THR A 1 263 ? -12.796 -16.006 -12.532 1.00 16.35 ? 257 THR A CB  1 
ATOM   1649 O  OG1 . THR A 1 263 ? -11.655 -15.177 -12.291 1.00 14.71 ? 257 THR A OG1 1 
ATOM   1650 C  CG2 . THR A 1 263 ? -12.623 -17.345 -11.787 1.00 15.88 ? 257 THR A CG2 1 
ATOM   1651 N  N   . ALA A 1 264 ? -15.360 -16.394 -14.412 1.00 15.56 ? 258 ALA A N   1 
ATOM   1652 C  CA  . ALA A 1 264 ? -16.572 -17.120 -14.773 1.00 16.89 ? 258 ALA A CA  1 
ATOM   1653 C  C   . ALA A 1 264 ? -16.474 -17.691 -16.190 1.00 17.08 ? 258 ALA A C   1 
ATOM   1654 O  O   . ALA A 1 264 ? -16.803 -18.857 -16.424 1.00 15.70 ? 258 ALA A O   1 
ATOM   1655 C  CB  . ALA A 1 264 ? -17.794 -16.214 -14.624 1.00 16.15 ? 258 ALA A CB  1 
ATOM   1656 N  N   . ALA A 1 265 ? -16.030 -16.889 -17.158 1.00 15.08 ? 259 ALA A N   1 
ATOM   1657 C  CA  . ALA A 1 265 ? -15.915 -17.425 -18.514 1.00 16.43 ? 259 ALA A CA  1 
ATOM   1658 C  C   . ALA A 1 265 ? -14.909 -18.571 -18.567 1.00 19.23 ? 259 ALA A C   1 
ATOM   1659 O  O   . ALA A 1 265 ? -15.138 -19.584 -19.245 1.00 19.55 ? 259 ALA A O   1 
ATOM   1660 C  CB  . ALA A 1 265 ? -15.525 -16.319 -19.497 1.00 14.36 ? 259 ALA A CB  1 
ATOM   1661 N  N   . ALA A 1 266 ? -13.785 -18.434 -17.858 1.00 15.47 ? 260 ALA A N   1 
ATOM   1662 C  CA  . ALA A 1 266 ? -12.780 -19.491 -17.876 1.00 16.45 ? 260 ALA A CA  1 
ATOM   1663 C  C   . ALA A 1 266 ? -13.304 -20.743 -17.190 1.00 20.76 ? 260 ALA A C   1 
ATOM   1664 O  O   . ALA A 1 266 ? -13.125 -21.854 -17.695 1.00 16.75 ? 260 ALA A O   1 
ATOM   1665 C  CB  . ALA A 1 266 ? -11.495 -19.002 -17.209 1.00 16.09 ? 260 ALA A CB  1 
ATOM   1666 N  N   . GLY A 1 267 ? -13.963 -20.581 -16.036 1.00 16.42 ? 261 GLY A N   1 
ATOM   1667 C  CA  . GLY A 1 267 ? -14.541 -21.730 -15.375 1.00 16.31 ? 261 GLY A CA  1 
ATOM   1668 C  C   . GLY A 1 267 ? -15.548 -22.440 -16.257 1.00 18.57 ? 261 GLY A C   1 
ATOM   1669 O  O   . GLY A 1 267 ? -15.575 -23.670 -16.322 1.00 14.76 ? 261 GLY A O   1 
ATOM   1670 N  N   . LEU A 1 268 ? -16.384 -21.669 -16.958 1.00 16.45 ? 262 LEU A N   1 
ATOM   1671 C  CA  . LEU A 1 268 ? -17.347 -22.264 -17.871 1.00 17.26 ? 262 LEU A CA  1 
ATOM   1672 C  C   . LEU A 1 268 ? -16.644 -23.074 -18.954 1.00 20.34 ? 262 LEU A C   1 
ATOM   1673 O  O   . LEU A 1 268 ? -17.035 -24.209 -19.240 1.00 17.98 ? 262 LEU A O   1 
ATOM   1674 C  CB  . LEU A 1 268 ? -18.224 -21.181 -18.491 1.00 19.72 ? 262 LEU A CB  1 
ATOM   1675 C  CG  . LEU A 1 268 ? -19.261 -21.726 -19.471 1.00 20.98 ? 262 LEU A CG  1 
ATOM   1676 C  CD1 . LEU A 1 268 ? -20.173 -22.705 -18.784 1.00 17.57 ? 262 LEU A CD1 1 
ATOM   1677 C  CD2 . LEU A 1 268 ? -20.060 -20.570 -20.077 1.00 20.36 ? 262 LEU A CD2 1 
ATOM   1678 N  N   . ALA A 1 269 ? -15.590 -22.509 -19.553 1.00 19.35 ? 263 ALA A N   1 
ATOM   1679 C  CA  . ALA A 1 269 ? -14.857 -23.209 -20.608 1.00 19.70 ? 263 ALA A CA  1 
ATOM   1680 C  C   . ALA A 1 269 ? -14.210 -24.476 -20.072 1.00 24.05 ? 263 ALA A C   1 
ATOM   1681 O  O   . ALA A 1 269 ? -14.275 -25.539 -20.705 1.00 21.96 ? 263 ALA A O   1 
ATOM   1682 C  CB  . ALA A 1 269 ? -13.787 -22.301 -21.210 1.00 14.65 ? 263 ALA A CB  1 
ATOM   1683 N  N   . LEU A 1 270 ? -13.563 -24.376 -18.907 1.00 18.57 ? 264 LEU A N   1 
ATOM   1684 C  CA  . LEU A 1 270 ? -12.946 -25.556 -18.310 1.00 19.96 ? 264 LEU A CA  1 
ATOM   1685 C  C   . LEU A 1 270 ? -13.976 -26.627 -17.992 1.00 21.11 ? 264 LEU A C   1 
ATOM   1686 O  O   . LEU A 1 270 ? -13.671 -27.818 -18.077 1.00 24.95 ? 264 LEU A O   1 
ATOM   1687 C  CB  . LEU A 1 270 ? -12.185 -25.172 -17.038 1.00 21.49 ? 264 LEU A CB  1 
ATOM   1688 C  CG  . LEU A 1 270 ? -10.952 -24.312 -17.313 1.00 21.59 ? 264 LEU A CG  1 
ATOM   1689 C  CD1 . LEU A 1 270 ? -10.316 -23.877 -15.994 1.00 25.92 ? 264 LEU A CD1 1 
ATOM   1690 C  CD2 . LEU A 1 270 ? -9.974  -25.108 -18.165 1.00 16.00 ? 264 LEU A CD2 1 
ATOM   1691 N  N   . SER A 1 271 ? -15.190 -26.235 -17.610 1.00 21.65 ? 265 SER A N   1 
ATOM   1692 C  CA  . SER A 1 271 ? -16.180 -27.226 -17.223 1.00 24.38 ? 265 SER A CA  1 
ATOM   1693 C  C   . SER A 1 271 ? -16.807 -27.924 -18.426 1.00 25.84 ? 265 SER A C   1 
ATOM   1694 O  O   . SER A 1 271 ? -17.403 -28.995 -18.264 1.00 24.65 ? 265 SER A O   1 
ATOM   1695 C  CB  . SER A 1 271 ? -17.250 -26.573 -16.350 1.00 23.27 ? 265 SER A CB  1 
ATOM   1696 O  OG  . SER A 1 271 ? -18.294 -26.035 -17.129 1.00 29.53 ? 265 SER A OG  1 
ATOM   1697 N  N   . LEU A 1 272 ? -16.640 -27.366 -19.625 1.00 25.18 ? 266 LEU A N   1 
ATOM   1698 C  CA  . LEU A 1 272 ? -17.048 -28.027 -20.854 1.00 26.47 ? 266 LEU A CA  1 
ATOM   1699 C  C   . LEU A 1 272 ? -16.023 -29.047 -21.342 1.00 28.01 ? 266 LEU A C   1 
ATOM   1700 O  O   . LEU A 1 272 ? -16.331 -29.823 -22.252 1.00 28.18 ? 266 LEU A O   1 
ATOM   1701 C  CB  . LEU A 1 272 ? -17.302 -26.972 -21.937 1.00 24.95 ? 266 LEU A CB  1 
ATOM   1702 C  CG  . LEU A 1 272 ? -18.509 -26.073 -21.667 1.00 28.64 ? 266 LEU A CG  1 
ATOM   1703 C  CD1 . LEU A 1 272 ? -18.450 -24.824 -22.526 1.00 26.03 ? 266 LEU A CD1 1 
ATOM   1704 C  CD2 . LEU A 1 272 ? -19.830 -26.818 -21.859 1.00 24.06 ? 266 LEU A CD2 1 
ATOM   1705 N  N   . LEU A 1 273 ? -14.820 -29.078 -20.769 1.00 28.11 ? 267 LEU A N   1 
ATOM   1706 C  CA  . LEU A 1 273 ? -13.821 -30.023 -21.248 1.00 28.06 ? 267 LEU A CA  1 
ATOM   1707 C  C   . LEU A 1 273 ? -14.230 -31.467 -20.943 1.00 30.12 ? 267 LEU A C   1 
ATOM   1708 O  O   . LEU A 1 273 ? -15.090 -31.726 -20.090 1.00 23.62 ? 267 LEU A O   1 
ATOM   1709 C  CB  . LEU A 1 273 ? -12.456 -29.727 -20.634 1.00 26.10 ? 267 LEU A CB  1 
ATOM   1710 C  CG  . LEU A 1 273 ? -11.722 -28.510 -21.201 1.00 26.02 ? 267 LEU A CG  1 
ATOM   1711 C  CD1 . LEU A 1 273 ? -10.412 -28.291 -20.459 1.00 23.21 ? 267 LEU A CD1 1 
ATOM   1712 C  CD2 . LEU A 1 273 ? -11.479 -28.671 -22.699 1.00 24.70 ? 267 LEU A CD2 1 
ATOM   1713 N  N   . PRO A 1 274 ? -13.633 -32.433 -21.652 1.00 34.34 ? 268 PRO A N   1 
ATOM   1714 C  CA  . PRO A 1 274 ? -13.965 -33.842 -21.373 1.00 35.86 ? 268 PRO A CA  1 
ATOM   1715 C  C   . PRO A 1 274 ? -13.755 -34.189 -19.915 1.00 30.54 ? 268 PRO A C   1 
ATOM   1716 O  O   . PRO A 1 274 ? -14.631 -34.805 -19.294 1.00 31.86 ? 268 PRO A O   1 
ATOM   1717 C  CB  . PRO A 1 274 ? -13.017 -34.623 -22.304 1.00 32.61 ? 268 PRO A CB  1 
ATOM   1718 C  CG  . PRO A 1 274 ? -12.636 -33.658 -23.367 1.00 34.27 ? 268 PRO A CG  1 
ATOM   1719 C  CD  . PRO A 1 274 ? -12.608 -32.301 -22.700 1.00 31.75 ? 268 PRO A CD  1 
ATOM   1720 N  N   . ALA A 1 275 ? -12.610 -33.804 -19.354 1.00 30.00 ? 269 ALA A N   1 
ATOM   1721 C  CA  . ALA A 1 275 ? -12.301 -34.008 -17.939 1.00 35.23 ? 269 ALA A CA  1 
ATOM   1722 C  C   . ALA A 1 275 ? -11.935 -32.666 -17.301 1.00 32.04 ? 269 ALA A C   1 
ATOM   1723 O  O   . ALA A 1 275 ? -10.781 -32.218 -17.402 1.00 30.39 ? 269 ALA A O   1 
ATOM   1724 C  CB  . ALA A 1 275 ? -11.171 -35.022 -17.773 1.00 30.07 ? 269 ALA A CB  1 
ATOM   1725 N  N   . PRO A 1 276 ? -12.880 -31.987 -16.655 1.00 28.19 ? 270 PRO A N   1 
ATOM   1726 C  CA  . PRO A 1 276 ? -12.574 -30.646 -16.084 1.00 32.18 ? 270 PRO A CA  1 
ATOM   1727 C  C   . PRO A 1 276 ? -11.495 -30.731 -15.021 1.00 28.52 ? 270 PRO A C   1 
ATOM   1728 O  O   . PRO A 1 276 ? -11.443 -31.701 -14.250 1.00 27.95 ? 270 PRO A O   1 
ATOM   1729 C  CB  . PRO A 1 276 ? -13.917 -30.193 -15.488 1.00 24.75 ? 270 PRO A CB  1 
ATOM   1730 C  CG  . PRO A 1 276 ? -14.960 -30.973 -16.317 1.00 31.80 ? 270 PRO A CG  1 
ATOM   1731 C  CD  . PRO A 1 276 ? -14.313 -32.321 -16.579 1.00 29.01 ? 270 PRO A CD  1 
ATOM   1732 N  N   . PRO A 1 277 ? -10.604 -29.746 -14.950 1.00 25.68 ? 271 PRO A N   1 
ATOM   1733 C  CA  . PRO A 1 277 ? -9.553  -29.780 -13.930 1.00 24.69 ? 271 PRO A CA  1 
ATOM   1734 C  C   . PRO A 1 277 ? -10.144 -29.585 -12.539 1.00 24.72 ? 271 PRO A C   1 
ATOM   1735 O  O   . PRO A 1 277 ? -11.315 -29.242 -12.367 1.00 24.68 ? 271 PRO A O   1 
ATOM   1736 C  CB  . PRO A 1 277 ? -8.640  -28.614 -14.315 1.00 21.16 ? 271 PRO A CB  1 
ATOM   1737 C  CG  . PRO A 1 277 ? -9.555  -27.653 -14.963 1.00 20.47 ? 271 PRO A CG  1 
ATOM   1738 C  CD  . PRO A 1 277 ? -10.554 -28.497 -15.735 1.00 22.81 ? 271 PRO A CD  1 
ATOM   1739 N  N   . ALA A 1 278 ? -9.292  -29.800 -11.531 1.00 24.73 ? 272 ALA A N   1 
ATOM   1740 C  CA  . ALA A 1 278 ? -9.733  -29.686 -10.142 1.00 28.41 ? 272 ALA A CA  1 
ATOM   1741 C  C   . ALA A 1 278 ? -9.988  -28.239 -9.752  1.00 26.04 ? 272 ALA A C   1 
ATOM   1742 O  O   . ALA A 1 278 ? -10.899 -27.956 -8.962  1.00 24.75 ? 272 ALA A O   1 
ATOM   1743 C  CB  . ALA A 1 278 ? -8.693  -30.302 -9.200  1.00 29.87 ? 272 ALA A CB  1 
ATOM   1744 N  N   . CYS A 1 279 ? -9.201  -27.316 -10.302 1.00 24.18 ? 273 CYS A N   1 
ATOM   1745 C  CA  . CYS A 1 279 ? -9.305  -25.911 -9.948  1.00 24.43 ? 273 CYS A CA  1 
ATOM   1746 C  C   . CYS A 1 279 ? -10.673 -25.296 -10.249 1.00 24.30 ? 273 CYS A C   1 
ATOM   1747 O  O   . CYS A 1 279 ? -10.888 -24.146 -9.866  1.00 24.32 ? 273 CYS A O   1 
ATOM   1748 C  CB  . CYS A 1 279 ? -8.197  -25.150 -10.673 1.00 29.56 ? 273 CYS A CB  1 
ATOM   1749 S  SG  . CYS A 1 279 ? -8.550  -24.925 -12.438 1.00 31.12 ? 273 CYS A SG  1 
ATOM   1750 N  N   . VAL A 1 280 ? -11.611 -26.000 -10.895 1.00 21.31 ? 274 VAL A N   1 
ATOM   1751 C  CA  . VAL A 1 280 ? -12.922 -25.371 -11.083 1.00 21.94 ? 274 VAL A CA  1 
ATOM   1752 C  C   . VAL A 1 280 ? -13.634 -25.164 -9.751  1.00 23.12 ? 274 VAL A C   1 
ATOM   1753 O  O   . VAL A 1 280 ? -14.465 -24.256 -9.628  1.00 17.37 ? 274 VAL A O   1 
ATOM   1754 C  CB  . VAL A 1 280 ? -13.829 -26.158 -12.048 1.00 19.85 ? 274 VAL A CB  1 
ATOM   1755 C  CG1 . VAL A 1 280 ? -13.230 -26.196 -13.445 1.00 20.99 ? 274 VAL A CG1 1 
ATOM   1756 C  CG2 . VAL A 1 280 ? -14.112 -27.549 -11.512 1.00 23.59 ? 274 VAL A CG2 1 
ATOM   1757 N  N   . THR A 1 281 ? -13.359 -26.008 -8.739  1.00 20.63 ? 275 THR A N   1 
ATOM   1758 C  CA  . THR A 1 281 ? -14.051 -25.847 -7.459  1.00 23.29 ? 275 THR A CA  1 
ATOM   1759 C  C   . THR A 1 281 ? -13.601 -24.596 -6.724  1.00 17.73 ? 275 THR A C   1 
ATOM   1760 O  O   . THR A 1 281 ? -14.465 -23.791 -6.331  1.00 20.01 ? 275 THR A O   1 
ATOM   1761 C  CB  . THR A 1 281 ? -13.863 -27.097 -6.599  1.00 22.96 ? 275 THR A CB  1 
ATOM   1762 O  OG1 . THR A 1 281 ? -14.567 -28.172 -7.224  1.00 21.92 ? 275 THR A OG1 1 
ATOM   1763 C  CG2 . THR A 1 281 ? -14.424 -26.854 -5.191  1.00 23.24 ? 275 THR A CG2 1 
ATOM   1764 N  N   . PRO A 1 282 ? -12.311 -24.358 -6.510  1.00 18.50 ? 276 PRO A N   1 
ATOM   1765 C  CA  . PRO A 1 282 ? -11.894 -23.059 -5.958  1.00 20.98 ? 276 PRO A CA  1 
ATOM   1766 C  C   . PRO A 1 282 ? -12.333 -21.869 -6.791  1.00 18.07 ? 276 PRO A C   1 
ATOM   1767 O  O   . PRO A 1 282 ? -12.539 -20.797 -6.214  1.00 15.83 ? 276 PRO A O   1 
ATOM   1768 C  CB  . PRO A 1 282 ? -10.359 -23.170 -5.892  1.00 19.72 ? 276 PRO A CB  1 
ATOM   1769 C  CG  . PRO A 1 282 ? -10.008 -24.436 -6.669  1.00 23.72 ? 276 PRO A CG  1 
ATOM   1770 C  CD  . PRO A 1 282 ? -11.206 -25.331 -6.521  1.00 22.47 ? 276 PRO A CD  1 
ATOM   1771 N  N   . MET A 1 283 ? -12.483 -22.012 -8.124  1.00 18.25 ? 277 MET A N   1 
ATOM   1772 C  CA  . MET A 1 283 ? -13.008 -20.897 -8.916  1.00 19.83 ? 277 MET A CA  1 
ATOM   1773 C  C   . MET A 1 283 ? -14.487 -20.669 -8.644  1.00 17.81 ? 277 MET A C   1 
ATOM   1774 O  O   . MET A 1 283 ? -14.915 -19.518 -8.482  1.00 16.81 ? 277 MET A O   1 
ATOM   1775 C  CB  . MET A 1 283 ? -12.762 -21.097 -10.421 1.00 16.65 ? 277 MET A CB  1 
ATOM   1776 C  CG  . MET A 1 283 ? -11.340 -21.421 -10.798 1.00 14.57 ? 277 MET A CG  1 
ATOM   1777 S  SD  . MET A 1 283 ? -11.126 -21.988 -12.519 1.00 24.51 ? 277 MET A SD  1 
ATOM   1778 C  CE  . MET A 1 283 ? -11.806 -20.629 -13.512 1.00 21.81 ? 277 MET A CE  1 
ATOM   1779 N  N   . ALA A 1 284 ? -15.280 -21.744 -8.567  1.00 14.32 ? 278 ALA A N   1 
ATOM   1780 C  CA  . ALA A 1 284 ? -16.674 -21.593 -8.166  1.00 15.83 ? 278 ALA A CA  1 
ATOM   1781 C  C   . ALA A 1 284 ? -16.781 -20.955 -6.780  1.00 20.13 ? 278 ALA A C   1 
ATOM   1782 O  O   . ALA A 1 284 ? -17.611 -20.059 -6.560  1.00 18.51 ? 278 ALA A O   1 
ATOM   1783 C  CB  . ALA A 1 284 ? -17.383 -22.952 -8.195  1.00 17.18 ? 278 ALA A CB  1 
ATOM   1784 N  N   . ASP A 1 285 ? -15.937 -21.391 -5.835  1.00 19.08 ? 279 ASP A N   1 
ATOM   1785 C  CA  . ASP A 1 285 ? -15.936 -20.792 -4.502  1.00 19.27 ? 279 ASP A CA  1 
ATOM   1786 C  C   . ASP A 1 285 ? -15.587 -19.311 -4.571  1.00 18.88 ? 279 ASP A C   1 
ATOM   1787 O  O   . ASP A 1 285 ? -16.228 -18.487 -3.910  1.00 17.27 ? 279 ASP A O   1 
ATOM   1788 C  CB  . ASP A 1 285 ? -14.943 -21.523 -3.588  1.00 18.37 ? 279 ASP A CB  1 
ATOM   1789 C  CG  . ASP A 1 285 ? -15.310 -22.997 -3.357  1.00 22.51 ? 279 ASP A CG  1 
ATOM   1790 O  OD1 . ASP A 1 285 ? -16.439 -23.410 -3.696  1.00 21.43 ? 279 ASP A OD1 1 
ATOM   1791 O  OD2 . ASP A 1 285 ? -14.457 -23.748 -2.812  1.00 26.01 ? 279 ASP A OD2 1 
ATOM   1792 N  N   . ALA A 1 286 ? -14.574 -18.953 -5.370  1.00 17.18 ? 280 ALA A N   1 
ATOM   1793 C  CA  . ALA A 1 286 ? -14.152 -17.557 -5.425  1.00 15.99 ? 280 ALA A CA  1 
ATOM   1794 C  C   . ALA A 1 286 ? -15.245 -16.664 -6.003  1.00 16.81 ? 280 ALA A C   1 
ATOM   1795 O  O   . ALA A 1 286 ? -15.418 -15.515 -5.570  1.00 17.10 ? 280 ALA A O   1 
ATOM   1796 C  CB  . ALA A 1 286 ? -12.867 -17.422 -6.230  1.00 13.89 ? 280 ALA A CB  1 
ATOM   1797 N  N   . LEU A 1 287 ? -16.001 -17.173 -6.973  1.00 15.26 ? 281 LEU A N   1 
ATOM   1798 C  CA  . LEU A 1 287 ? -17.101 -16.387 -7.523  1.00 15.36 ? 281 LEU A CA  1 
ATOM   1799 C  C   . LEU A 1 287 ? -18.228 -16.237 -6.512  1.00 15.93 ? 281 LEU A C   1 
ATOM   1800 O  O   . LEU A 1 287 ? -18.679 -15.121 -6.235  1.00 18.41 ? 281 LEU A O   1 
ATOM   1801 C  CB  . LEU A 1 287 ? -17.616 -17.037 -8.816  1.00 15.53 ? 281 LEU A CB  1 
ATOM   1802 C  CG  . LEU A 1 287 ? -16.556 -17.025 -9.918  1.00 16.77 ? 281 LEU A CG  1 
ATOM   1803 C  CD1 . LEU A 1 287 ? -16.985 -17.823 -11.144 1.00 18.09 ? 281 LEU A CD1 1 
ATOM   1804 C  CD2 . LEU A 1 287 ? -16.277 -15.594 -10.292 1.00 16.81 ? 281 LEU A CD2 1 
ATOM   1805 N  N   . ALA A 1 288 ? -18.680 -17.358 -5.931  1.00 15.16 ? 282 ALA A N   1 
ATOM   1806 C  CA  . ALA A 1 288 ? -19.865 -17.342 -5.082  1.00 17.60 ? 282 ALA A CA  1 
ATOM   1807 C  C   . ALA A 1 288 ? -19.685 -16.462 -3.848  1.00 16.95 ? 282 ALA A C   1 
ATOM   1808 O  O   . ALA A 1 288 ? -20.650 -15.858 -3.378  1.00 18.10 ? 282 ALA A O   1 
ATOM   1809 C  CB  . ALA A 1 288 ? -20.215 -18.768 -4.655  1.00 16.84 ? 282 ALA A CB  1 
ATOM   1810 N  N   . LEU A 1 289 ? -18.474 -16.386 -3.303  1.00 15.09 ? 283 LEU A N   1 
ATOM   1811 C  CA  . LEU A 1 289 ? -18.273 -15.555 -2.125  1.00 18.60 ? 283 LEU A CA  1 
ATOM   1812 C  C   . LEU A 1 289 ? -18.206 -14.072 -2.478  1.00 23.49 ? 283 LEU A C   1 
ATOM   1813 O  O   . LEU A 1 289 ? -18.246 -13.230 -1.570  1.00 20.31 ? 283 LEU A O   1 
ATOM   1814 C  CB  . LEU A 1 289 ? -17.016 -16.002 -1.366  1.00 15.62 ? 283 LEU A CB  1 
ATOM   1815 C  CG  . LEU A 1 289 ? -15.624 -15.873 -1.998  1.00 16.15 ? 283 LEU A CG  1 
ATOM   1816 C  CD1 . LEU A 1 289 ? -15.007 -14.493 -1.701  1.00 17.46 ? 283 LEU A CD1 1 
ATOM   1817 C  CD2 . LEU A 1 289 ? -14.739 -16.969 -1.492  1.00 14.40 ? 283 LEU A CD2 1 
ATOM   1818 N  N   . ARG A 1 290 ? -18.170 -13.737 -3.772  1.00 15.46 ? 284 ARG A N   1 
ATOM   1819 C  CA  . ARG A 1 290 ? -18.166 -12.356 -4.210  1.00 15.85 ? 284 ARG A CA  1 
ATOM   1820 C  C   . ARG A 1 290 ? -19.543 -11.876 -4.637  1.00 17.66 ? 284 ARG A C   1 
ATOM   1821 O  O   . ARG A 1 290 ? -19.669 -10.733 -5.085  1.00 17.53 ? 284 ARG A O   1 
ATOM   1822 C  CB  . ARG A 1 290 ? -17.156 -12.171 -5.355  1.00 15.08 ? 284 ARG A CB  1 
ATOM   1823 C  CG  . ARG A 1 290 ? -15.714 -12.382 -4.864  1.00 17.09 ? 284 ARG A CG  1 
ATOM   1824 C  CD  . ARG A 1 290 ? -14.660 -12.114 -5.911  1.00 14.75 ? 284 ARG A CD  1 
ATOM   1825 N  NE  . ARG A 1 290 ? -13.367 -11.833 -5.281  1.00 17.65 ? 284 ARG A NE  1 
ATOM   1826 C  CZ  . ARG A 1 290 ? -12.585 -12.736 -4.698  1.00 19.13 ? 284 ARG A CZ  1 
ATOM   1827 N  NH1 . ARG A 1 290 ? -12.908 -14.026 -4.670  1.00 15.03 ? 284 ARG A NH1 1 
ATOM   1828 N  NH2 . ARG A 1 290 ? -11.436 -12.340 -4.151  1.00 19.03 ? 284 ARG A NH2 1 
ATOM   1829 N  N   . ARG A 1 291 ? -20.582 -12.697 -4.491  1.00 13.59 ? 285 ARG A N   1 
ATOM   1830 C  CA  . ARG A 1 291 ? -21.892 -12.279 -4.972  1.00 18.22 ? 285 ARG A CA  1 
ATOM   1831 C  C   . ARG A 1 291 ? -22.413 -11.084 -4.174  1.00 21.28 ? 285 ARG A C   1 
ATOM   1832 O  O   . ARG A 1 291 ? -22.116 -10.921 -2.979  1.00 16.65 ? 285 ARG A O   1 
ATOM   1833 C  CB  . ARG A 1 291 ? -22.891 -13.437 -4.909  1.00 17.91 ? 285 ARG A CB  1 
ATOM   1834 C  CG  . ARG A 1 291 ? -23.333 -13.850 -3.520  1.00 18.77 ? 285 ARG A CG  1 
ATOM   1835 C  CD  . ARG A 1 291 ? -24.089 -15.186 -3.620  1.00 23.88 ? 285 ARG A CD  1 
ATOM   1836 N  NE  . ARG A 1 291 ? -24.566 -15.693 -2.340  1.00 22.25 ? 285 ARG A NE  1 
ATOM   1837 C  CZ  . ARG A 1 291 ? -23.816 -16.351 -1.469  1.00 21.75 ? 285 ARG A CZ  1 
ATOM   1838 N  NH1 . ARG A 1 291 ? -22.519 -16.517 -1.657  1.00 19.01 ? 285 ARG A NH1 1 
ATOM   1839 N  NH2 . ARG A 1 291 ? -24.380 -16.856 -0.380  1.00 23.95 ? 285 ARG A NH2 1 
ATOM   1840 N  N   . ASN A 1 292 ? -23.181 -10.223 -4.863  1.00 21.55 ? 286 ASN A N   1 
ATOM   1841 C  CA  . ASN A 1 292 ? -23.742 -9.031  -4.239  1.00 18.23 ? 286 ASN A CA  1 
ATOM   1842 C  C   . ASN A 1 292 ? -25.033 -9.368  -3.486  1.00 22.13 ? 286 ASN A C   1 
ATOM   1843 O  O   . ASN A 1 292 ? -25.621 -10.438 -3.684  1.00 18.69 ? 286 ASN A O   1 
ATOM   1844 C  CB  . ASN A 1 292 ? -24.021 -7.963  -5.287  1.00 17.55 ? 286 ASN A CB  1 
ATOM   1845 C  CG  . ASN A 1 292 ? -22.760 -7.406  -5.910  1.00 19.57 ? 286 ASN A CG  1 
ATOM   1846 O  OD1 . ASN A 1 292 ? -21.724 -7.245  -5.253  1.00 18.81 ? 286 ASN A OD1 1 
ATOM   1847 N  ND2 . ASN A 1 292 ? -22.834 -7.123  -7.202  1.00 17.92 ? 286 ASN A ND2 1 
ATOM   1848 N  N   . PRO A 1 293 ? -25.495 -8.460  -2.615  1.00 22.99 ? 287 PRO A N   1 
ATOM   1849 C  CA  . PRO A 1 293 ? -26.706 -8.752  -1.825  1.00 22.00 ? 287 PRO A CA  1 
ATOM   1850 C  C   . PRO A 1 293 ? -27.928 -9.070  -2.675  1.00 24.63 ? 287 PRO A C   1 
ATOM   1851 O  O   . PRO A 1 293 ? -28.770 -9.878  -2.250  1.00 24.51 ? 287 PRO A O   1 
ATOM   1852 C  CB  . PRO A 1 293 ? -26.907 -7.470  -0.992  1.00 21.23 ? 287 PRO A CB  1 
ATOM   1853 C  CG  . PRO A 1 293 ? -25.519 -6.851  -0.896  1.00 19.71 ? 287 PRO A CG  1 
ATOM   1854 C  CD  . PRO A 1 293 ? -24.852 -7.185  -2.221  1.00 19.60 ? 287 PRO A CD  1 
ATOM   1855 N  N   . ASP A 1 294 ? -28.055 -8.477  -3.865  1.00 19.95 ? 288 ASP A N   1 
ATOM   1856 C  CA  . ASP A 1 294 ? -29.170 -8.809  -4.741  1.00 19.50 ? 288 ASP A CA  1 
ATOM   1857 C  C   . ASP A 1 294 ? -29.003 -10.160 -5.428  1.00 23.84 ? 288 ASP A C   1 
ATOM   1858 O  O   . ASP A 1 294 ? -29.886 -10.562 -6.193  1.00 20.29 ? 288 ASP A O   1 
ATOM   1859 C  CB  . ASP A 1 294 ? -29.403 -7.690  -5.787  1.00 23.87 ? 288 ASP A CB  1 
ATOM   1860 C  CG  . ASP A 1 294 ? -28.181 -7.405  -6.670  1.00 21.46 ? 288 ASP A CG  1 
ATOM   1861 O  OD1 . ASP A 1 294 ? -27.209 -8.184  -6.666  1.00 21.03 ? 288 ASP A OD1 1 
ATOM   1862 O  OD2 . ASP A 1 294 ? -28.192 -6.375  -7.374  1.00 24.42 ? 288 ASP A OD2 1 
ATOM   1863 N  N   . GLY A 1 295 ? -27.913 -10.884 -5.172  1.00 21.10 ? 289 GLY A N   1 
ATOM   1864 C  CA  . GLY A 1 295 ? -27.718 -12.177 -5.783  1.00 20.83 ? 289 GLY A CA  1 
ATOM   1865 C  C   . GLY A 1 295 ? -27.013 -12.172 -7.123  1.00 20.92 ? 289 GLY A C   1 
ATOM   1866 O  O   . GLY A 1 295 ? -26.641 -13.251 -7.602  1.00 21.35 ? 289 GLY A O   1 
ATOM   1867 N  N   . GLY A 1 296 ? -26.823 -11.003 -7.746  1.00 20.09 ? 290 GLY A N   1 
ATOM   1868 C  CA  . GLY A 1 296 ? -26.090 -10.898 -8.991  1.00 20.20 ? 290 GLY A CA  1 
ATOM   1869 C  C   . GLY A 1 296 ? -24.609 -10.696 -8.745  1.00 18.64 ? 290 GLY A C   1 
ATOM   1870 O  O   . GLY A 1 296 ? -24.139 -10.704 -7.606  1.00 18.84 ? 290 GLY A O   1 
ATOM   1871 N  N   . TYR A 1 297 ? -23.866 -10.477 -9.850  1.00 18.78 ? 291 TYR A N   1 
ATOM   1872 C  CA  . TYR A 1 297 ? -22.408 -10.349 -9.844  1.00 15.99 ? 291 TYR A CA  1 
ATOM   1873 C  C   . TYR A 1 297 ? -21.979 -9.123  -10.640 1.00 19.76 ? 291 TYR A C   1 
ATOM   1874 O  O   . TYR A 1 297 ? -22.584 -8.796  -11.666 1.00 17.74 ? 291 TYR A O   1 
ATOM   1875 C  CB  . TYR A 1 297 ? -21.734 -11.631 -10.418 1.00 15.88 ? 291 TYR A CB  1 
ATOM   1876 C  CG  . TYR A 1 297 ? -22.036 -12.840 -9.557  1.00 17.65 ? 291 TYR A CG  1 
ATOM   1877 C  CD1 . TYR A 1 297 ? -23.247 -13.516 -9.685  1.00 15.32 ? 291 TYR A CD1 1 
ATOM   1878 C  CD2 . TYR A 1 297 ? -21.150 -13.262 -8.571  1.00 14.99 ? 291 TYR A CD2 1 
ATOM   1879 C  CE1 . TYR A 1 297 ? -23.548 -14.597 -8.884  1.00 17.65 ? 291 TYR A CE1 1 
ATOM   1880 C  CE2 . TYR A 1 297 ? -21.447 -14.337 -7.761  1.00 15.97 ? 291 TYR A CE2 1 
ATOM   1881 C  CZ  . TYR A 1 297 ? -22.646 -14.999 -7.917  1.00 17.88 ? 291 TYR A CZ  1 
ATOM   1882 O  OH  . TYR A 1 297 ? -22.963 -16.063 -7.110  1.00 15.61 ? 291 TYR A OH  1 
ATOM   1883 N  N   . GLY A 1 298 ? -20.951 -8.422  -10.138 1.00 19.12 ? 292 GLY A N   1 
ATOM   1884 C  CA  . GLY A 1 298 ? -20.264 -7.406  -10.911 1.00 20.00 ? 292 GLY A CA  1 
ATOM   1885 C  C   . GLY A 1 298 ? -19.091 -7.990  -11.693 1.00 20.16 ? 292 GLY A C   1 
ATOM   1886 O  O   . GLY A 1 298 ? -18.783 -9.178  -11.607 1.00 18.37 ? 292 GLY A O   1 
ATOM   1887 N  N   . PHE A 1 299 ? -18.424 -7.128  -12.473 1.00 17.88 ? 293 PHE A N   1 
ATOM   1888 C  CA  . PHE A 1 299 ? -17.385 -7.607  -13.391 1.00 18.53 ? 293 PHE A CA  1 
ATOM   1889 C  C   . PHE A 1 299 ? -16.022 -7.836  -12.722 1.00 18.79 ? 293 PHE A C   1 
ATOM   1890 O  O   . PHE A 1 299 ? -15.228 -8.615  -13.251 1.00 16.28 ? 293 PHE A O   1 
ATOM   1891 C  CB  . PHE A 1 299 ? -17.229 -6.640  -14.580 1.00 21.00 ? 293 PHE A CB  1 
ATOM   1892 C  CG  . PHE A 1 299 ? -16.864 -5.210  -14.184 1.00 21.07 ? 293 PHE A CG  1 
ATOM   1893 C  CD1 . PHE A 1 299 ? -17.854 -4.276  -13.899 1.00 21.77 ? 293 PHE A CD1 1 
ATOM   1894 C  CD2 . PHE A 1 299 ? -15.534 -4.806  -14.127 1.00 17.22 ? 293 PHE A CD2 1 
ATOM   1895 C  CE1 . PHE A 1 299 ? -17.523 -2.961  -13.545 1.00 20.07 ? 293 PHE A CE1 1 
ATOM   1896 C  CE2 . PHE A 1 299 ? -15.198 -3.514  -13.773 1.00 17.26 ? 293 PHE A CE2 1 
ATOM   1897 C  CZ  . PHE A 1 299 ? -16.193 -2.588  -13.473 1.00 20.14 ? 293 PHE A CZ  1 
ATOM   1898 N  N   . HIS A 1 300 ? -15.754 -7.217  -11.566 1.00 14.37 ? 294 HIS A N   1 
ATOM   1899 C  CA  . HIS A 1 300 ? -14.466 -7.281  -10.877 1.00 15.50 ? 294 HIS A CA  1 
ATOM   1900 C  C   . HIS A 1 300 ? -14.735 -7.331  -9.381  1.00 18.58 ? 294 HIS A C   1 
ATOM   1901 O  O   . HIS A 1 300 ? -15.839 -7.019  -8.926  1.00 19.39 ? 294 HIS A O   1 
ATOM   1902 C  CB  . HIS A 1 300 ? -13.584 -6.059  -11.219 1.00 18.72 ? 294 HIS A CB  1 
ATOM   1903 C  CG  . HIS A 1 300 ? -12.138 -6.183  -10.814 1.00 22.75 ? 294 HIS A CG  1 
ATOM   1904 N  ND1 . HIS A 1 300 ? -11.239 -6.991  -11.477 1.00 22.47 ? 294 HIS A ND1 1 
ATOM   1905 C  CD2 . HIS A 1 300 ? -11.429 -5.555  -9.843  1.00 22.40 ? 294 HIS A CD2 1 
ATOM   1906 C  CE1 . HIS A 1 300 ? -10.046 -6.873  -10.917 1.00 22.68 ? 294 HIS A CE1 1 
ATOM   1907 N  NE2 . HIS A 1 300 ? -10.134 -6.003  -9.929  1.00 18.83 ? 294 HIS A NE2 1 
ATOM   1908 N  N   . SER A 1 301 ? -13.718 -7.722  -8.611  1.00 14.87 ? 295 SER A N   1 
ATOM   1909 C  CA  . SER A 1 301 ? -13.815 -7.627  -7.154  1.00 19.77 ? 295 SER A CA  1 
ATOM   1910 C  C   . SER A 1 301 ? -14.188 -6.207  -6.733  1.00 19.85 ? 295 SER A C   1 
ATOM   1911 O  O   . SER A 1 301 ? -13.589 -5.234  -7.201  1.00 20.20 ? 295 SER A O   1 
ATOM   1912 C  CB  . SER A 1 301 ? -12.485 -8.014  -6.498  1.00 20.79 ? 295 SER A CB  1 
ATOM   1913 O  OG  . SER A 1 301 ? -12.181 -9.374  -6.742  1.00 24.14 ? 295 SER A OG  1 
ATOM   1914 N  N   . GLY A 1 302 ? -15.167 -6.088  -5.836  1.00 20.48 ? 296 GLY A N   1 
ATOM   1915 C  CA  . GLY A 1 302 ? -15.522 -4.785  -5.290  1.00 21.15 ? 296 GLY A CA  1 
ATOM   1916 C  C   . GLY A 1 302 ? -16.408 -3.933  -6.170  1.00 22.82 ? 296 GLY A C   1 
ATOM   1917 O  O   . GLY A 1 302 ? -16.429 -2.714  -6.010  1.00 25.20 ? 296 GLY A O   1 
ATOM   1918 N  N   . VAL A 1 303 ? -17.114 -4.530  -7.120  1.00 20.23 ? 297 VAL A N   1 
ATOM   1919 C  CA  . VAL A 1 303 ? -18.106 -3.838  -7.927  1.00 20.59 ? 297 VAL A CA  1 
ATOM   1920 C  C   . VAL A 1 303 ? -19.457 -4.191  -7.322  1.00 23.30 ? 297 VAL A C   1 
ATOM   1921 O  O   . VAL A 1 303 ? -19.930 -5.325  -7.465  1.00 22.80 ? 297 VAL A O   1 
ATOM   1922 C  CB  . VAL A 1 303 ? -18.012 -4.245  -9.411  1.00 18.95 ? 297 VAL A CB  1 
ATOM   1923 C  CG1 . VAL A 1 303 ? -19.135 -3.634  -10.238 1.00 18.40 ? 297 VAL A CG1 1 
ATOM   1924 C  CG2 . VAL A 1 303 ? -16.662 -3.854  -9.981  1.00 19.15 ? 297 VAL A CG2 1 
ATOM   1925 N  N   . ALA A 1 304 ? -20.071 -3.237  -6.617  1.00 21.40 ? 298 ALA A N   1 
ATOM   1926 C  CA  . ALA A 1 304 ? -21.373 -3.489  -6.012  1.00 21.86 ? 298 ALA A CA  1 
ATOM   1927 C  C   . ALA A 1 304 ? -22.507 -3.488  -7.035  1.00 19.99 ? 298 ALA A C   1 
ATOM   1928 O  O   . ALA A 1 304 ? -23.564 -4.064  -6.774  1.00 17.01 ? 298 ALA A O   1 
ATOM   1929 C  CB  . ALA A 1 304 ? -21.653 -2.456  -4.915  1.00 26.59 ? 298 ALA A CB  1 
ATOM   1930 N  N   . GLN A 1 305 ? -22.308 -2.902  -8.205  1.00 20.46 ? 299 GLN A N   1 
ATOM   1931 C  CA  . GLN A 1 305 ? -23.326 -2.944  -9.247  1.00 18.06 ? 299 GLN A CA  1 
ATOM   1932 C  C   . GLN A 1 305 ? -23.314 -4.314  -9.926  1.00 22.47 ? 299 GLN A C   1 
ATOM   1933 O  O   . GLN A 1 305 ? -22.357 -4.647  -10.631 1.00 21.76 ? 299 GLN A O   1 
ATOM   1934 C  CB  . GLN A 1 305 ? -23.066 -1.841  -10.265 1.00 24.01 ? 299 GLN A CB  1 
ATOM   1935 C  CG  . GLN A 1 305 ? -23.970 -1.915  -11.477 1.00 24.02 ? 299 GLN A CG  1 
ATOM   1936 C  CD  . GLN A 1 305 ? -25.374 -1.520  -11.121 1.00 28.21 ? 299 GLN A CD  1 
ATOM   1937 O  OE1 . GLN A 1 305 ? -25.638 -0.348  -10.845 1.00 35.38 ? 299 GLN A OE1 1 
ATOM   1938 N  NE2 . GLN A 1 305 ? -26.288 -2.492  -11.105 1.00 25.08 ? 299 GLN A NE2 1 
ATOM   1939 N  N   . SER A 1 306 ? -24.371 -5.112  -9.720  1.00 20.49 ? 300 SER A N   1 
ATOM   1940 C  CA  . SER A 1 306 ? -24.582 -6.336  -10.485 1.00 20.41 ? 300 SER A CA  1 
ATOM   1941 C  C   . SER A 1 306 ? -25.033 -6.030  -11.919 1.00 21.26 ? 300 SER A C   1 
ATOM   1942 O  O   . SER A 1 306 ? -25.598 -4.968  -12.214 1.00 19.93 ? 300 SER A O   1 
ATOM   1943 C  CB  . SER A 1 306 ? -25.630 -7.226  -9.807  1.00 22.13 ? 300 SER A CB  1 
ATOM   1944 O  OG  . SER A 1 306 ? -25.228 -7.602  -8.496  1.00 19.27 ? 300 SER A OG  1 
ATOM   1945 N  N   . ASP A 1 307 ? -24.772 -6.984  -12.821 1.00 20.20 ? 301 ASP A N   1 
ATOM   1946 C  CA  . ASP A 1 307 ? -25.261 -6.908  -14.200 1.00 19.09 ? 301 ASP A CA  1 
ATOM   1947 C  C   . ASP A 1 307 ? -25.610 -8.304  -14.725 1.00 17.78 ? 301 ASP A C   1 
ATOM   1948 O  O   . ASP A 1 307 ? -25.118 -9.316  -14.227 1.00 15.36 ? 301 ASP A O   1 
ATOM   1949 C  CB  . ASP A 1 307 ? -24.238 -6.234  -15.120 1.00 20.22 ? 301 ASP A CB  1 
ATOM   1950 C  CG  . ASP A 1 307 ? -23.004 -7.093  -15.352 1.00 25.24 ? 301 ASP A CG  1 
ATOM   1951 O  OD1 . ASP A 1 307 ? -23.020 -7.961  -16.262 1.00 25.62 ? 301 ASP A OD1 1 
ATOM   1952 O  OD2 . ASP A 1 307 ? -22.012 -6.900  -14.610 1.00 30.50 ? 301 ASP A OD2 1 
ATOM   1953 N  N   . VAL A 1 308 ? -26.476 -8.331  -15.750 1.00 20.52 ? 302 VAL A N   1 
ATOM   1954 C  CA  . VAL A 1 308 ? -27.030 -9.576  -16.298 1.00 18.13 ? 302 VAL A CA  1 
ATOM   1955 C  C   . VAL A 1 308 ? -25.947 -10.425 -16.948 1.00 19.59 ? 302 VAL A C   1 
ATOM   1956 O  O   . VAL A 1 308 ? -25.975 -11.660 -16.853 1.00 20.29 ? 302 VAL A O   1 
ATOM   1957 C  CB  . VAL A 1 308 ? -28.150 -9.270  -17.310 1.00 17.59 ? 302 VAL A CB  1 
ATOM   1958 C  CG1 . VAL A 1 308 ? -28.430 -10.488 -18.198 1.00 19.02 ? 302 VAL A CG1 1 
ATOM   1959 C  CG2 . VAL A 1 308 ? -29.407 -8.818  -16.625 1.00 19.16 ? 302 VAL A CG2 1 
ATOM   1960 N  N   . GLU A 1 309 ? -24.995 -9.794  -17.644 1.00 17.80 ? 303 GLU A N   1 
ATOM   1961 C  CA  . GLU A 1 309 ? -23.977 -10.564 -18.357 1.00 18.16 ? 303 GLU A CA  1 
ATOM   1962 C  C   . GLU A 1 309 ? -23.070 -11.323 -17.391 1.00 23.28 ? 303 GLU A C   1 
ATOM   1963 O  O   . GLU A 1 309 ? -22.808 -12.526 -17.569 1.00 17.81 ? 303 GLU A O   1 
ATOM   1964 C  CB  . GLU A 1 309 ? -23.145 -9.647  -19.253 1.00 23.08 ? 303 GLU A CB  1 
ATOM   1965 C  CG  . GLU A 1 309 ? -21.940 -10.346 -19.882 1.00 26.18 ? 303 GLU A CG  1 
ATOM   1966 C  CD  . GLU A 1 309 ? -22.086 -10.512 -21.395 1.00 35.00 ? 303 GLU A CD  1 
ATOM   1967 O  OE1 . GLU A 1 309 ? -22.650 -11.545 -21.823 1.00 40.00 ? 303 GLU A OE1 1 
ATOM   1968 O  OE2 . GLU A 1 309 ? -21.648 -9.610  -22.152 1.00 35.61 ? 303 GLU A OE2 1 
ATOM   1969 N  N   . ASP A 1 310 ? -22.557 -10.634 -16.371 1.00 21.47 ? 304 ASP A N   1 
ATOM   1970 C  CA  . ASP A 1 310 ? -21.721 -11.321 -15.399 1.00 18.18 ? 304 ASP A CA  1 
ATOM   1971 C  C   . ASP A 1 310 ? -22.491 -12.407 -14.684 1.00 17.96 ? 304 ASP A C   1 
ATOM   1972 O  O   . ASP A 1 310 ? -21.974 -13.509 -14.478 1.00 19.99 ? 304 ASP A O   1 
ATOM   1973 C  CB  . ASP A 1 310 ? -21.143 -10.338 -14.395 1.00 18.63 ? 304 ASP A CB  1 
ATOM   1974 C  CG  . ASP A 1 310 ? -20.016 -9.555  -14.983 1.00 26.25 ? 304 ASP A CG  1 
ATOM   1975 O  OD1 . ASP A 1 310 ? -18.901 -10.127 -15.038 1.00 28.42 ? 304 ASP A OD1 1 
ATOM   1976 O  OD2 . ASP A 1 310 ? -20.219 -8.381  -15.364 1.00 27.66 ? 304 ASP A OD2 1 
ATOM   1977 N  N   . THR A 1 311 ? -23.729 -12.112 -14.293 1.00 17.96 ? 305 THR A N   1 
ATOM   1978 C  CA  . THR A 1 311 ? -24.501 -13.077 -13.530 1.00 18.99 ? 305 THR A CA  1 
ATOM   1979 C  C   . THR A 1 311 ? -24.760 -14.350 -14.348 1.00 16.01 ? 305 THR A C   1 
ATOM   1980 O  O   . THR A 1 311 ? -24.651 -15.463 -13.826 1.00 15.08 ? 305 THR A O   1 
ATOM   1981 C  CB  . THR A 1 311 ? -25.783 -12.393 -13.046 1.00 17.49 ? 305 THR A CB  1 
ATOM   1982 O  OG1 . THR A 1 311 ? -25.421 -11.221 -12.293 1.00 18.66 ? 305 THR A OG1 1 
ATOM   1983 C  CG2 . THR A 1 311 ? -26.611 -13.312 -12.143 1.00 16.61 ? 305 THR A CG2 1 
ATOM   1984 N  N   . CYS A 1 312 ? -25.011 -14.208 -15.651 1.00 16.56 ? 306 CYS A N   1 
ATOM   1985 C  CA  . CYS A 1 312 ? -25.287 -15.377 -16.486 1.00 20.53 ? 306 CYS A CA  1 
ATOM   1986 C  C   . CYS A 1 312 ? -24.067 -16.279 -16.618 1.00 20.60 ? 306 CYS A C   1 
ATOM   1987 O  O   . CYS A 1 312 ? -24.195 -17.503 -16.577 1.00 20.38 ? 306 CYS A O   1 
ATOM   1988 C  CB  . CYS A 1 312 ? -25.769 -14.935 -17.862 1.00 17.20 ? 306 CYS A CB  1 
ATOM   1989 S  SG  . CYS A 1 312 ? -27.438 -14.276 -17.791 1.00 21.19 ? 306 CYS A SG  1 
ATOM   1990 N  N   . TYR A 1 313 ? -22.877 -15.696 -16.774 1.00 19.43 ? 307 TYR A N   1 
ATOM   1991 C  CA  . TYR A 1 313 ? -21.673 -16.516 -16.853 1.00 20.23 ? 307 TYR A CA  1 
ATOM   1992 C  C   . TYR A 1 313 ? -21.385 -17.206 -15.521 1.00 18.85 ? 307 TYR A C   1 
ATOM   1993 O  O   . TYR A 1 313 ? -21.005 -18.373 -15.504 1.00 15.11 ? 307 TYR A O   1 
ATOM   1994 C  CB  . TYR A 1 313 ? -20.479 -15.669 -17.286 1.00 20.18 ? 307 TYR A CB  1 
ATOM   1995 C  CG  . TYR A 1 313 ? -20.300 -15.554 -18.790 1.00 23.65 ? 307 TYR A CG  1 
ATOM   1996 C  CD1 . TYR A 1 313 ? -19.825 -16.625 -19.547 1.00 25.16 ? 307 TYR A CD1 1 
ATOM   1997 C  CD2 . TYR A 1 313 ? -20.605 -14.365 -19.454 1.00 26.32 ? 307 TYR A CD2 1 
ATOM   1998 C  CE1 . TYR A 1 313 ? -19.657 -16.508 -20.938 1.00 25.49 ? 307 TYR A CE1 1 
ATOM   1999 C  CE2 . TYR A 1 313 ? -20.436 -14.238 -20.832 1.00 27.95 ? 307 TYR A CE2 1 
ATOM   2000 C  CZ  . TYR A 1 313 ? -19.965 -15.316 -21.564 1.00 28.04 ? 307 TYR A CZ  1 
ATOM   2001 O  OH  . TYR A 1 313 ? -19.811 -15.186 -22.916 1.00 27.91 ? 307 TYR A OH  1 
ATOM   2002 N  N   . VAL A 1 314 ? -21.527 -16.500 -14.392 1.00 19.11 ? 308 VAL A N   1 
ATOM   2003 C  CA  . VAL A 1 314 ? -21.376 -17.183 -13.107 1.00 18.45 ? 308 VAL A CA  1 
ATOM   2004 C  C   . VAL A 1 314 ? -22.431 -18.283 -12.978 1.00 16.77 ? 308 VAL A C   1 
ATOM   2005 O  O   . VAL A 1 314 ? -22.127 -19.416 -12.606 1.00 17.85 ? 308 VAL A O   1 
ATOM   2006 C  CB  . VAL A 1 314 ? -21.439 -16.180 -11.932 1.00 16.73 ? 308 VAL A CB  1 
ATOM   2007 C  CG1 . VAL A 1 314 ? -21.256 -16.903 -10.608 1.00 17.28 ? 308 VAL A CG1 1 
ATOM   2008 C  CG2 . VAL A 1 314 ? -20.370 -15.120 -12.071 1.00 15.84 ? 308 VAL A CG2 1 
ATOM   2009 N  N   . LEU A 1 315 ? -23.672 -17.980 -13.350 1.00 18.30 ? 309 LEU A N   1 
ATOM   2010 C  CA  . LEU A 1 315 ? -24.755 -18.945 -13.207 1.00 18.65 ? 309 LEU A CA  1 
ATOM   2011 C  C   . LEU A 1 315 ? -24.508 -20.191 -14.059 1.00 21.73 ? 309 LEU A C   1 
ATOM   2012 O  O   . LEU A 1 315 ? -24.531 -21.319 -13.547 1.00 20.34 ? 309 LEU A O   1 
ATOM   2013 C  CB  . LEU A 1 315 ? -26.082 -18.264 -13.556 1.00 17.96 ? 309 LEU A CB  1 
ATOM   2014 C  CG  . LEU A 1 315 ? -27.414 -18.986 -13.360 1.00 21.56 ? 309 LEU A CG  1 
ATOM   2015 C  CD1 . LEU A 1 315 ? -27.388 -19.918 -12.157 1.00 21.76 ? 309 LEU A CD1 1 
ATOM   2016 C  CD2 . LEU A 1 315 ? -28.490 -17.948 -13.193 1.00 23.33 ? 309 LEU A CD2 1 
ATOM   2017 N  N   . GLU A 1 316 ? -24.275 -20.015 -15.368 1.00 20.10 ? 310 GLU A N   1 
ATOM   2018 C  CA  . GLU A 1 316 ? -23.945 -21.163 -16.214 1.00 19.24 ? 310 GLU A CA  1 
ATOM   2019 C  C   . GLU A 1 316 ? -22.797 -21.973 -15.629 1.00 21.67 ? 310 GLU A C   1 
ATOM   2020 O  O   . GLU A 1 316 ? -22.851 -23.209 -15.599 1.00 21.50 ? 310 GLU A O   1 
ATOM   2021 C  CB  . GLU A 1 316 ? -23.585 -20.718 -17.634 1.00 23.81 ? 310 GLU A CB  1 
ATOM   2022 C  CG  . GLU A 1 316 ? -24.636 -19.860 -18.293 1.00 29.09 ? 310 GLU A CG  1 
ATOM   2023 C  CD  . GLU A 1 316 ? -25.698 -20.693 -18.998 1.00 38.40 ? 310 GLU A CD  1 
ATOM   2024 O  OE1 . GLU A 1 316 ? -26.072 -21.763 -18.453 1.00 38.49 ? 310 GLU A OE1 1 
ATOM   2025 O  OE2 . GLU A 1 316 ? -26.171 -20.256 -20.079 1.00 38.46 ? 310 GLU A OE2 1 
ATOM   2026 N  N   . PHE A 1 317 ? -21.750 -21.296 -15.155 1.00 20.99 ? 311 PHE A N   1 
ATOM   2027 C  CA  . PHE A 1 317 ? -20.592 -22.007 -14.624 1.00 18.82 ? 311 PHE A CA  1 
ATOM   2028 C  C   . PHE A 1 317 ? -20.948 -22.800 -13.368 1.00 18.13 ? 311 PHE A C   1 
ATOM   2029 O  O   . PHE A 1 317 ? -20.585 -23.972 -13.247 1.00 21.66 ? 311 PHE A O   1 
ATOM   2030 C  CB  . PHE A 1 317 ? -19.457 -21.022 -14.341 1.00 17.09 ? 311 PHE A CB  1 
ATOM   2031 C  CG  . PHE A 1 317 ? -18.289 -21.634 -13.614 1.00 17.37 ? 311 PHE A CG  1 
ATOM   2032 C  CD1 . PHE A 1 317 ? -17.820 -22.897 -13.959 1.00 17.16 ? 311 PHE A CD1 1 
ATOM   2033 C  CD2 . PHE A 1 317 ? -17.660 -20.946 -12.584 1.00 16.14 ? 311 PHE A CD2 1 
ATOM   2034 C  CE1 . PHE A 1 317 ? -16.732 -23.466 -13.283 1.00 17.57 ? 311 PHE A CE1 1 
ATOM   2035 C  CE2 . PHE A 1 317 ? -16.578 -21.494 -11.919 1.00 15.93 ? 311 PHE A CE2 1 
ATOM   2036 C  CZ  . PHE A 1 317 ? -16.117 -22.771 -12.258 1.00 16.64 ? 311 PHE A CZ  1 
ATOM   2037 N  N   . LEU A 1 318 ? -21.645 -22.178 -12.415 1.00 19.59 ? 312 LEU A N   1 
ATOM   2038 C  CA  . LEU A 1 318 ? -21.919 -22.853 -11.145 1.00 21.77 ? 312 LEU A CA  1 
ATOM   2039 C  C   . LEU A 1 318 ? -22.881 -24.027 -11.334 1.00 23.23 ? 312 LEU A C   1 
ATOM   2040 O  O   . LEU A 1 318 ? -22.777 -25.038 -10.628 1.00 19.41 ? 312 LEU A O   1 
ATOM   2041 C  CB  . LEU A 1 318 ? -22.476 -21.864 -10.109 1.00 21.34 ? 312 LEU A CB  1 
ATOM   2042 C  CG  . LEU A 1 318 ? -21.555 -20.766 -9.535  1.00 23.84 ? 312 LEU A CG  1 
ATOM   2043 C  CD1 . LEU A 1 318 ? -22.248 -19.998 -8.421  1.00 16.37 ? 312 LEU A CD1 1 
ATOM   2044 C  CD2 . LEU A 1 318 ? -20.256 -21.356 -9.016  1.00 22.07 ? 312 LEU A CD2 1 
ATOM   2045 N  N   . ARG A 1 319 ? -23.831 -23.897 -12.266 1.00 21.50 ? 313 ARG A N   1 
ATOM   2046 C  CA  . ARG A 1 319 ? -24.759 -24.980 -12.586 1.00 24.97 ? 313 ARG A CA  1 
ATOM   2047 C  C   . ARG A 1 319 ? -24.021 -26.222 -13.055 1.00 23.52 ? 313 ARG A C   1 
ATOM   2048 O  O   . ARG A 1 319 ? -24.450 -27.345 -12.780 1.00 31.71 ? 313 ARG A O   1 
ATOM   2049 C  CB  . ARG A 1 319 ? -25.733 -24.529 -13.670 1.00 32.92 ? 313 ARG A CB  1 
ATOM   2050 C  CG  . ARG A 1 319 ? -26.944 -23.786 -13.161 1.00 39.49 ? 313 ARG A CG  1 
ATOM   2051 C  CD  . ARG A 1 319 ? -28.202 -24.495 -13.565 1.00 46.30 ? 313 ARG A CD  1 
ATOM   2052 N  NE  . ARG A 1 319 ? -29.333 -24.093 -12.739 1.00 50.26 ? 313 ARG A NE  1 
ATOM   2053 C  CZ  . ARG A 1 319 ? -29.765 -24.789 -11.693 1.00 50.49 ? 313 ARG A CZ  1 
ATOM   2054 N  NH1 . ARG A 1 319 ? -29.114 -25.862 -11.255 1.00 43.13 ? 313 ARG A NH1 1 
ATOM   2055 N  NH2 . ARG A 1 319 ? -30.871 -24.398 -11.064 1.00 50.55 ? 313 ARG A NH2 1 
ATOM   2056 N  N   . ARG A 1 320 ? -22.931 -26.042 -13.794 1.00 23.23 ? 314 ARG A N   1 
ATOM   2057 C  CA  . ARG A 1 320 ? -22.155 -27.169 -14.292 1.00 23.25 ? 314 ARG A CA  1 
ATOM   2058 C  C   . ARG A 1 320 ? -21.147 -27.689 -13.285 1.00 23.65 ? 314 ARG A C   1 
ATOM   2059 O  O   . ARG A 1 320 ? -20.998 -28.902 -13.152 1.00 26.84 ? 314 ARG A O   1 
ATOM   2060 C  CB  . ARG A 1 320 ? -21.424 -26.783 -15.580 1.00 24.83 ? 314 ARG A CB  1 
ATOM   2061 C  CG  . ARG A 1 320 ? -22.361 -26.299 -16.652 1.00 26.17 ? 314 ARG A CG  1 
ATOM   2062 C  CD  . ARG A 1 320 ? -21.652 -26.009 -17.956 1.00 28.80 ? 314 ARG A CD  1 
ATOM   2063 N  NE  . ARG A 1 320 ? -22.629 -26.041 -19.035 1.00 35.61 ? 314 ARG A NE  1 
ATOM   2064 C  CZ  . ARG A 1 320 ? -23.612 -25.162 -19.177 1.00 39.78 ? 314 ARG A CZ  1 
ATOM   2065 N  NH1 . ARG A 1 320 ? -23.718 -24.100 -18.385 1.00 33.11 ? 314 ARG A NH1 1 
ATOM   2066 N  NH2 . ARG A 1 320 ? -24.513 -25.352 -20.135 1.00 42.98 ? 314 ARG A NH2 1 
ATOM   2067 N  N   . ALA A 1 321 ? -20.442 -26.816 -12.567 1.00 22.16 ? 315 ALA A N   1 
ATOM   2068 C  CA  . ALA A 1 321 ? -19.330 -27.287 -11.750 1.00 22.01 ? 315 ALA A CA  1 
ATOM   2069 C  C   . ALA A 1 321 ? -19.650 -27.372 -10.259 1.00 22.90 ? 315 ALA A C   1 
ATOM   2070 O  O   . ALA A 1 321 ? -18.853 -27.934 -9.500  1.00 25.81 ? 315 ALA A O   1 
ATOM   2071 C  CB  . ALA A 1 321 ? -18.098 -26.396 -11.964 1.00 20.15 ? 315 ALA A CB  1 
ATOM   2072 N  N   . ALA A 1 322 ? -20.773 -26.858 -9.818  1.00 22.34 ? 316 ALA A N   1 
ATOM   2073 C  CA  . ALA A 1 322 ? -20.987 -26.841 -8.376  1.00 20.60 ? 316 ALA A CA  1 
ATOM   2074 C  C   . ALA A 1 322 ? -22.458 -26.648 -8.057  1.00 22.75 ? 316 ALA A C   1 
ATOM   2075 O  O   . ALA A 1 322 ? -22.802 -25.825 -7.198  1.00 24.57 ? 316 ALA A O   1 
ATOM   2076 C  CB  . ALA A 1 322 ? -20.166 -25.720 -7.728  1.00 19.32 ? 316 ALA A CB  1 
ATOM   2077 N  N   . PRO A 1 323 ? -23.356 -27.371 -8.723  1.00 22.35 ? 317 PRO A N   1 
ATOM   2078 C  CA  . PRO A 1 323 ? -24.788 -27.079 -8.545  1.00 22.95 ? 317 PRO A CA  1 
ATOM   2079 C  C   . PRO A 1 323 ? -25.284 -27.333 -7.137  1.00 25.12 ? 317 PRO A C   1 
ATOM   2080 O  O   . PRO A 1 323 ? -26.277 -26.723 -6.721  1.00 27.10 ? 317 PRO A O   1 
ATOM   2081 C  CB  . PRO A 1 323 ? -25.461 -28.017 -9.559  1.00 28.06 ? 317 PRO A CB  1 
ATOM   2082 C  CG  . PRO A 1 323 ? -24.515 -29.153 -9.701  1.00 26.14 ? 317 PRO A CG  1 
ATOM   2083 C  CD  . PRO A 1 323 ? -23.128 -28.574 -9.544  1.00 24.50 ? 317 PRO A CD  1 
ATOM   2084 N  N   . ASP A 1 324 ? -24.641 -28.237 -6.396  1.00 27.08 ? 318 ASP A N   1 
ATOM   2085 C  CA  . ASP A 1 324 ? -25.025 -28.526 -5.015  1.00 31.32 ? 318 ASP A CA  1 
ATOM   2086 C  C   . ASP A 1 324 ? -24.172 -27.761 -4.008  1.00 26.98 ? 318 ASP A C   1 
ATOM   2087 O  O   . ASP A 1 324 ? -24.704 -27.101 -3.112  1.00 27.77 ? 318 ASP A O   1 
ATOM   2088 C  CB  . ASP A 1 324 ? -24.939 -30.041 -4.740  1.00 31.25 ? 318 ASP A CB  1 
ATOM   2089 C  CG  . ASP A 1 324 ? -25.986 -30.832 -5.521  1.00 38.44 ? 318 ASP A CG  1 
ATOM   2090 O  OD1 . ASP A 1 324 ? -27.191 -30.495 -5.394  1.00 42.73 ? 318 ASP A OD1 1 
ATOM   2091 O  OD2 . ASP A 1 324 ? -25.607 -31.764 -6.279  1.00 44.32 ? 318 ASP A OD2 1 
ATOM   2092 N  N   . ARG A 1 325 ? -22.850 -27.826 -4.157  1.00 22.44 ? 319 ARG A N   1 
ATOM   2093 C  CA  . ARG A 1 325 ? -21.970 -27.045 -3.305  1.00 24.86 ? 319 ARG A CA  1 
ATOM   2094 C  C   . ARG A 1 325 ? -22.420 -25.592 -3.231  1.00 26.97 ? 319 ARG A C   1 
ATOM   2095 O  O   . ARG A 1 325 ? -22.322 -24.959 -2.179  1.00 27.77 ? 319 ARG A O   1 
ATOM   2096 C  CB  . ARG A 1 325 ? -20.548 -27.141 -3.833  1.00 23.47 ? 319 ARG A CB  1 
ATOM   2097 C  CG  . ARG A 1 325 ? -19.502 -26.523 -2.971  1.00 22.31 ? 319 ARG A CG  1 
ATOM   2098 C  CD  . ARG A 1 325 ? -18.173 -26.809 -3.615  1.00 21.06 ? 319 ARG A CD  1 
ATOM   2099 N  NE  . ARG A 1 325 ? -17.053 -26.120 -2.995  1.00 20.24 ? 319 ARG A NE  1 
ATOM   2100 C  CZ  . ARG A 1 325 ? -16.236 -26.698 -2.125  1.00 24.60 ? 319 ARG A CZ  1 
ATOM   2101 N  NH1 . ARG A 1 325 ? -16.452 -27.934 -1.692  1.00 20.24 ? 319 ARG A NH1 1 
ATOM   2102 N  NH2 . ARG A 1 325 ? -15.177 -26.024 -1.682  1.00 17.76 ? 319 ARG A NH2 1 
ATOM   2103 N  N   . HIS A 1 326 ? -22.944 -25.053 -4.331  1.00 26.06 ? 320 HIS A N   1 
ATOM   2104 C  CA  . HIS A 1 326 ? -23.300 -23.641 -4.405  1.00 26.65 ? 320 HIS A CA  1 
ATOM   2105 C  C   . HIS A 1 326 ? -24.762 -23.447 -4.772  1.00 24.83 ? 320 HIS A C   1 
ATOM   2106 O  O   . HIS A 1 326 ? -25.137 -22.492 -5.457  1.00 27.78 ? 320 HIS A O   1 
ATOM   2107 C  CB  . HIS A 1 326 ? -22.371 -22.923 -5.371  1.00 24.41 ? 320 HIS A CB  1 
ATOM   2108 C  CG  . HIS A 1 326 ? -21.006 -22.732 -4.804  1.00 21.93 ? 320 HIS A CG  1 
ATOM   2109 N  ND1 . HIS A 1 326 ? -20.795 -22.035 -3.636  1.00 21.60 ? 320 HIS A ND1 1 
ATOM   2110 C  CD2 . HIS A 1 326 ? -19.791 -23.151 -5.220  1.00 20.25 ? 320 HIS A CD2 1 
ATOM   2111 C  CE1 . HIS A 1 326 ? -19.505 -22.036 -3.355  1.00 20.37 ? 320 HIS A CE1 1 
ATOM   2112 N  NE2 . HIS A 1 326 ? -18.875 -22.712 -4.293  1.00 18.03 ? 320 HIS A NE2 1 
ATOM   2113 N  N   . ARG A 1 327 ? -25.602 -24.354 -4.270  1.00 28.49 ? 321 ARG A N   1 
ATOM   2114 C  CA  . ARG A 1 327 ? -27.026 -24.351 -4.584  1.00 28.49 ? 321 ARG A CA  1 
ATOM   2115 C  C   . ARG A 1 327 ? -27.686 -23.015 -4.250  1.00 23.88 ? 321 ARG A C   1 
ATOM   2116 O  O   . ARG A 1 327 ? -28.539 -22.522 -5.003  1.00 26.73 ? 321 ARG A O   1 
ATOM   2117 C  CB  . ARG A 1 327 ? -27.693 -25.498 -3.820  1.00 36.18 ? 321 ARG A CB  1 
ATOM   2118 C  CG  . ARG A 1 327 ? -29.200 -25.630 -4.021  1.00 35.96 ? 321 ARG A CG  1 
ATOM   2119 C  CD  . ARG A 1 327 ? -29.733 -26.842 -3.246  1.00 39.71 ? 321 ARG A CD  1 
ATOM   2120 N  NE  . ARG A 1 327 ? -29.107 -28.089 -3.671  1.00 42.56 ? 321 ARG A NE  1 
ATOM   2121 C  CZ  . ARG A 1 327 ? -28.323 -28.845 -2.908  1.00 49.91 ? 321 ARG A CZ  1 
ATOM   2122 N  NH1 . ARG A 1 327 ? -28.033 -28.505 -1.658  1.00 48.43 ? 321 ARG A NH1 1 
ATOM   2123 N  NH2 . ARG A 1 327 ? -27.817 -29.971 -3.411  1.00 40.47 ? 321 ARG A NH2 1 
ATOM   2124 N  N   . THR A 1 328 ? -27.321 -22.425 -3.118  1.00 25.43 ? 322 THR A N   1 
ATOM   2125 C  CA  . THR A 1 328 ? -27.922 -21.163 -2.704  1.00 26.97 ? 322 THR A CA  1 
ATOM   2126 C  C   . THR A 1 328 ? -27.459 -20.010 -3.589  1.00 23.43 ? 322 THR A C   1 
ATOM   2127 O  O   . THR A 1 328 ? -28.265 -19.157 -3.978  1.00 26.17 ? 322 THR A O   1 
ATOM   2128 C  CB  . THR A 1 328 ? -27.591 -20.904 -1.232  1.00 31.96 ? 322 THR A CB  1 
ATOM   2129 O  OG1 . THR A 1 328 ? -28.116 -21.983 -0.439  1.00 30.79 ? 322 THR A OG1 1 
ATOM   2130 C  CG2 . THR A 1 328 ? -28.191 -19.571 -0.753  1.00 27.69 ? 322 THR A CG2 1 
ATOM   2131 N  N   . ALA A 1 329 ? -26.170 -19.965 -3.925  1.00 21.76 ? 323 ALA A N   1 
ATOM   2132 C  CA  . ALA A 1 329 ? -25.708 -18.945 -4.861  1.00 25.03 ? 323 ALA A CA  1 
ATOM   2133 C  C   . ALA A 1 329 ? -26.442 -19.064 -6.190  1.00 24.51 ? 323 ALA A C   1 
ATOM   2134 O  O   . ALA A 1 329 ? -26.837 -18.055 -6.784  1.00 20.60 ? 323 ALA A O   1 
ATOM   2135 C  CB  . ALA A 1 329 ? -24.199 -19.063 -5.070  1.00 21.72 ? 323 ALA A CB  1 
ATOM   2136 N  N   . VAL A 1 330 ? -26.635 -20.300 -6.665  1.00 23.02 ? 324 VAL A N   1 
ATOM   2137 C  CA  . VAL A 1 330 ? -27.334 -20.525 -7.926  1.00 20.39 ? 324 VAL A CA  1 
ATOM   2138 C  C   . VAL A 1 330 ? -28.748 -19.977 -7.856  1.00 23.87 ? 324 VAL A C   1 
ATOM   2139 O  O   . VAL A 1 330 ? -29.206 -19.266 -8.760  1.00 24.44 ? 324 VAL A O   1 
ATOM   2140 C  CB  . VAL A 1 330 ? -27.339 -22.026 -8.271  1.00 24.64 ? 324 VAL A CB  1 
ATOM   2141 C  CG1 . VAL A 1 330 ? -28.444 -22.335 -9.276  1.00 22.47 ? 324 VAL A CG1 1 
ATOM   2142 C  CG2 . VAL A 1 330 ? -25.962 -22.472 -8.755  1.00 21.10 ? 324 VAL A CG2 1 
ATOM   2143 N  N   . ALA A 1 331 ? -29.471 -20.306 -6.787  1.00 21.37 ? 325 ALA A N   1 
ATOM   2144 C  CA  . ALA A 1 331 ? -30.854 -19.861 -6.708  1.00 22.83 ? 325 ALA A CA  1 
ATOM   2145 C  C   . ALA A 1 331 ? -30.940 -18.359 -6.516  1.00 22.86 ? 325 ALA A C   1 
ATOM   2146 O  O   . ALA A 1 331 ? -31.913 -17.739 -6.947  1.00 24.39 ? 325 ALA A O   1 
ATOM   2147 C  CB  . ALA A 1 331 ? -31.584 -20.574 -5.574  1.00 30.56 ? 325 ALA A CB  1 
ATOM   2148 N  N   . GLU A 1 332 ? -29.951 -17.758 -5.858  1.00 23.36 ? 326 GLU A N   1 
ATOM   2149 C  CA  . GLU A 1 332 ? -29.984 -16.313 -5.665  1.00 23.68 ? 326 GLU A CA  1 
ATOM   2150 C  C   . GLU A 1 332 ? -29.710 -15.582 -6.978  1.00 25.21 ? 326 GLU A C   1 
ATOM   2151 O  O   . GLU A 1 332 ? -30.155 -14.442 -7.169  1.00 22.76 ? 326 GLU A O   1 
ATOM   2152 C  CB  . GLU A 1 332 ? -28.970 -15.903 -4.593  1.00 20.83 ? 326 GLU A CB  1 
ATOM   2153 C  CG  . GLU A 1 332 ? -29.240 -16.480 -3.190  1.00 28.37 ? 326 GLU A CG  1 
ATOM   2154 C  CD  . GLU A 1 332 ? -28.364 -15.832 -2.101  1.00 33.69 ? 326 GLU A CD  1 
ATOM   2155 O  OE1 . GLU A 1 332 ? -27.368 -15.164 -2.459  1.00 29.10 ? 326 GLU A OE1 1 
ATOM   2156 O  OE2 . GLU A 1 332 ? -28.677 -15.971 -0.890  1.00 34.59 ? 326 GLU A OE2 1 
ATOM   2157 N  N   . ALA A 1 333 ? -28.989 -16.229 -7.893  1.00 22.95 ? 327 ALA A N   1 
ATOM   2158 C  CA  . ALA A 1 333 ? -28.673 -15.605 -9.165  1.00 22.71 ? 327 ALA A CA  1 
ATOM   2159 C  C   . ALA A 1 333 ? -29.870 -15.666 -10.112 1.00 21.80 ? 327 ALA A C   1 
ATOM   2160 O  O   . ALA A 1 333 ? -30.166 -14.688 -10.808 1.00 21.41 ? 327 ALA A O   1 
ATOM   2161 C  CB  . ALA A 1 333 ? -27.435 -16.286 -9.755  1.00 20.77 ? 327 ALA A CB  1 
ATOM   2162 N  N   . GLU A 1 334 ? -30.584 -16.796 -10.132 1.00 21.18 ? 328 GLU A N   1 
ATOM   2163 C  CA  . GLU A 1 334 ? -31.835 -16.860 -10.881 1.00 22.54 ? 328 GLU A CA  1 
ATOM   2164 C  C   . GLU A 1 334 ? -32.820 -15.822 -10.369 1.00 23.78 ? 328 GLU A C   1 
ATOM   2165 O  O   . GLU A 1 334 ? -33.473 -15.128 -11.157 1.00 24.34 ? 328 GLU A O   1 
ATOM   2166 C  CB  . GLU A 1 334 ? -32.441 -18.265 -10.787 1.00 21.77 ? 328 GLU A CB  1 
ATOM   2167 C  CG  . GLU A 1 334 ? -31.480 -19.366 -11.159 1.00 24.63 ? 328 GLU A CG  1 
ATOM   2168 C  CD  . GLU A 1 334 ? -32.065 -20.766 -10.922 1.00 41.65 ? 328 GLU A CD  1 
ATOM   2169 O  OE1 . GLU A 1 334 ? -33.111 -20.885 -10.238 1.00 41.73 ? 328 GLU A OE1 1 
ATOM   2170 O  OE2 . GLU A 1 334 ? -31.465 -21.749 -11.408 1.00 39.82 ? 328 GLU A OE2 1 
ATOM   2171 N  N   . GLY A 1 335 ? -32.944 -15.706 -9.042  1.00 24.29 ? 329 GLY A N   1 
ATOM   2172 C  CA  . GLY A 1 335 ? -33.829 -14.695 -8.495  1.00 23.67 ? 329 GLY A CA  1 
ATOM   2173 C  C   . GLY A 1 335 ? -33.461 -13.311 -8.976  1.00 21.62 ? 329 GLY A C   1 
ATOM   2174 O  O   . GLY A 1 335 ? -34.336 -12.511 -9.322  1.00 26.44 ? 329 GLY A O   1 
ATOM   2175 N  N   . TYR A 1 336 ? -32.155 -13.006 -8.993  1.00 22.42 ? 330 TYR A N   1 
ATOM   2176 C  CA  . TYR A 1 336 ? -31.672 -11.717 -9.493  1.00 23.14 ? 330 TYR A CA  1 
ATOM   2177 C  C   . TYR A 1 336 ? -32.120 -11.486 -10.934 1.00 22.44 ? 330 TYR A C   1 
ATOM   2178 O  O   . TYR A 1 336 ? -32.642 -10.419 -11.278 1.00 22.66 ? 330 TYR A O   1 
ATOM   2179 C  CB  . TYR A 1 336 ? -30.144 -11.662 -9.400  1.00 21.61 ? 330 TYR A CB  1 
ATOM   2180 C  CG  . TYR A 1 336 ? -29.543 -10.510 -10.183 1.00 21.55 ? 330 TYR A CG  1 
ATOM   2181 C  CD1 . TYR A 1 336 ? -29.468 -9.240  -9.629  1.00 22.34 ? 330 TYR A CD1 1 
ATOM   2182 C  CD2 . TYR A 1 336 ? -29.060 -10.690 -11.467 1.00 19.63 ? 330 TYR A CD2 1 
ATOM   2183 C  CE1 . TYR A 1 336 ? -28.934 -8.170  -10.327 1.00 21.67 ? 330 TYR A CE1 1 
ATOM   2184 C  CE2 . TYR A 1 336 ? -28.516 -9.620  -12.186 1.00 22.04 ? 330 TYR A CE2 1 
ATOM   2185 C  CZ  . TYR A 1 336 ? -28.465 -8.364  -11.611 1.00 21.75 ? 330 TYR A CZ  1 
ATOM   2186 O  OH  . TYR A 1 336 ? -27.920 -7.304  -12.304 1.00 20.36 ? 330 TYR A OH  1 
ATOM   2187 N  N   . LEU A 1 337 ? -31.919 -12.487 -11.793 1.00 23.14 ? 331 LEU A N   1 
ATOM   2188 C  CA  . LEU A 1 337 ? -32.303 -12.353 -13.195 1.00 20.59 ? 331 LEU A CA  1 
ATOM   2189 C  C   . LEU A 1 337 ? -33.812 -12.189 -13.329 1.00 25.06 ? 331 LEU A C   1 
ATOM   2190 O  O   . LEU A 1 337 ? -34.293 -11.305 -14.047 1.00 23.68 ? 331 LEU A O   1 
ATOM   2191 C  CB  . LEU A 1 337 ? -31.808 -13.575 -13.983 1.00 20.05 ? 331 LEU A CB  1 
ATOM   2192 C  CG  . LEU A 1 337 ? -30.301 -13.696 -14.256 1.00 19.88 ? 331 LEU A CG  1 
ATOM   2193 C  CD1 . LEU A 1 337 ? -29.958 -14.970 -15.055 1.00 15.89 ? 331 LEU A CD1 1 
ATOM   2194 C  CD2 . LEU A 1 337 ? -29.784 -12.451 -14.996 1.00 15.93 ? 331 LEU A CD2 1 
ATOM   2195 N  N   . LEU A 1 338 ? -34.578 -13.015 -12.612 1.00 25.92 ? 332 LEU A N   1 
ATOM   2196 C  CA  . LEU A 1 338 ? -36.034 -12.974 -12.737 1.00 30.38 ? 332 LEU A CA  1 
ATOM   2197 C  C   . LEU A 1 338 ? -36.620 -11.644 -12.258 1.00 29.43 ? 332 LEU A C   1 
ATOM   2198 O  O   . LEU A 1 338 ? -37.577 -11.138 -12.857 1.00 31.59 ? 332 LEU A O   1 
ATOM   2199 C  CB  . LEU A 1 338 ? -36.645 -14.155 -11.982 1.00 23.81 ? 332 LEU A CB  1 
ATOM   2200 C  CG  . LEU A 1 338 ? -36.420 -15.463 -12.734 1.00 27.29 ? 332 LEU A CG  1 
ATOM   2201 C  CD1 . LEU A 1 338 ? -36.627 -16.647 -11.810 1.00 36.80 ? 332 LEU A CD1 1 
ATOM   2202 C  CD2 . LEU A 1 338 ? -37.340 -15.554 -13.939 1.00 31.40 ? 332 LEU A CD2 1 
ATOM   2203 N  N   . ALA A 1 339 ? -36.071 -11.061 -11.188 1.00 29.01 ? 333 ALA A N   1 
ATOM   2204 C  CA  . ALA A 1 339 ? -36.539 -9.757  -10.720 1.00 25.25 ? 333 ALA A CA  1 
ATOM   2205 C  C   . ALA A 1 339 ? -36.233 -8.631  -11.696 1.00 29.81 ? 333 ALA A C   1 
ATOM   2206 O  O   . ALA A 1 339 ? -36.799 -7.545  -11.561 1.00 29.52 ? 333 ALA A O   1 
ATOM   2207 C  CB  . ALA A 1 339 ? -35.906 -9.414  -9.363  1.00 25.03 ? 333 ALA A CB  1 
ATOM   2208 N  N   . LEU A 1 340 ? -35.326 -8.843  -12.648 1.00 33.96 ? 334 LEU A N   1 
ATOM   2209 C  CA  . LEU A 1 340 ? -34.913 -7.805  -13.588 1.00 27.31 ? 334 LEU A CA  1 
ATOM   2210 C  C   . LEU A 1 340 ? -35.706 -7.826  -14.891 1.00 31.74 ? 334 LEU A C   1 
ATOM   2211 O  O   . LEU A 1 340 ? -35.633 -6.867  -15.667 1.00 32.67 ? 334 LEU A O   1 
ATOM   2212 C  CB  . LEU A 1 340 ? -33.418 -7.977  -13.913 1.00 31.84 ? 334 LEU A CB  1 
ATOM   2213 C  CG  . LEU A 1 340 ? -32.391 -6.987  -13.367 1.00 31.79 ? 334 LEU A CG  1 
ATOM   2214 C  CD1 . LEU A 1 340 ? -31.012 -7.462  -13.680 1.00 29.45 ? 334 LEU A CD1 1 
ATOM   2215 C  CD2 . LEU A 1 340 ? -32.631 -5.643  -14.005 1.00 39.53 ? 334 LEU A CD2 1 
ATOM   2216 N  N   . ARG A 1 341 ? -36.442 -8.902  -15.146 1.00 32.44 ? 335 ARG A N   1 
ATOM   2217 C  CA  . ARG A 1 341 ? -37.031 -9.135  -16.453 1.00 31.76 ? 335 ARG A CA  1 
ATOM   2218 C  C   . ARG A 1 341 ? -38.014 -8.035  -16.811 1.00 35.39 ? 335 ARG A C   1 
ATOM   2219 O  O   . ARG A 1 341 ? -38.819 -7.607  -15.982 1.00 36.23 ? 335 ARG A O   1 
ATOM   2220 C  CB  . ARG A 1 341 ? -37.734 -10.486 -16.462 1.00 32.01 ? 335 ARG A CB  1 
ATOM   2221 C  CG  . ARG A 1 341 ? -38.186 -10.915 -17.830 1.00 34.21 ? 335 ARG A CG  1 
ATOM   2222 C  CD  . ARG A 1 341 ? -38.463 -12.365 -17.797 1.00 31.81 ? 335 ARG A CD  1 
ATOM   2223 N  NE  . ARG A 1 341 ? -39.673 -12.633 -17.034 1.00 42.54 ? 335 ARG A NE  1 
ATOM   2224 C  CZ  . ARG A 1 341 ? -40.896 -12.539 -17.534 1.00 42.27 ? 335 ARG A CZ  1 
ATOM   2225 N  NH1 . ARG A 1 341 ? -41.102 -12.202 -18.796 1.00 40.26 ? 335 ARG A NH1 1 
ATOM   2226 N  NH2 . ARG A 1 341 ? -41.938 -12.801 -16.750 1.00 39.99 ? 335 ARG A NH2 1 
ATOM   2227 N  N   . ASN A 1 342 ? -37.943 -7.576  -18.058 1.00 34.57 ? 336 ASN A N   1 
ATOM   2228 C  CA  . ASN A 1 342 ? -38.853 -6.544  -18.523 1.00 39.25 ? 336 ASN A CA  1 
ATOM   2229 C  C   . ASN A 1 342 ? -40.190 -7.163  -18.922 1.00 39.21 ? 336 ASN A C   1 
ATOM   2230 O  O   . ASN A 1 342 ? -40.280 -8.364  -19.186 1.00 42.23 ? 336 ASN A O   1 
ATOM   2231 C  CB  . ASN A 1 342 ? -38.240 -5.781  -19.698 1.00 37.59 ? 336 ASN A CB  1 
ATOM   2232 C  CG  . ASN A 1 342 ? -37.250 -4.710  -19.253 1.00 36.28 ? 336 ASN A CG  1 
ATOM   2233 O  OD1 . ASN A 1 342 ? -37.334 -4.193  -18.138 1.00 43.35 ? 336 ASN A OD1 1 
ATOM   2234 N  ND2 . ASN A 1 342 ? -36.312 -4.368  -20.130 1.00 33.66 ? 336 ASN A ND2 1 
ATOM   2235 N  N   . PRO A 1 343 ? -41.257 -6.362  -18.963 1.00 48.44 ? 337 PRO A N   1 
ATOM   2236 C  CA  . PRO A 1 343 ? -42.569 -6.929  -19.318 1.00 51.53 ? 337 PRO A CA  1 
ATOM   2237 C  C   . PRO A 1 343 ? -42.670 -7.374  -20.774 1.00 45.39 ? 337 PRO A C   1 
ATOM   2238 O  O   . PRO A 1 343 ? -43.547 -8.187  -21.085 1.00 49.76 ? 337 PRO A O   1 
ATOM   2239 C  CB  . PRO A 1 343 ? -43.555 -5.794  -18.999 1.00 51.28 ? 337 PRO A CB  1 
ATOM   2240 C  CG  . PRO A 1 343 ? -42.731 -4.589  -18.647 1.00 49.10 ? 337 PRO A CG  1 
ATOM   2241 C  CD  . PRO A 1 343 ? -41.284 -4.898  -18.813 1.00 45.26 ? 337 PRO A CD  1 
ATOM   2242 N  N   . ASP A 1 344 ? -41.799 -6.896  -21.668 1.00 44.24 ? 338 ASP A N   1 
ATOM   2243 C  CA  . ASP A 1 344 ? -41.819 -7.320  -23.063 1.00 39.03 ? 338 ASP A CA  1 
ATOM   2244 C  C   . ASP A 1 344 ? -41.153 -8.675  -23.291 1.00 43.47 ? 338 ASP A C   1 
ATOM   2245 O  O   . ASP A 1 344 ? -41.038 -9.097  -24.449 1.00 42.60 ? 338 ASP A O   1 
ATOM   2246 C  CB  . ASP A 1 344 ? -41.171 -6.254  -23.970 1.00 36.30 ? 338 ASP A CB  1 
ATOM   2247 C  CG  . ASP A 1 344 ? -39.683 -6.039  -23.694 1.00 40.07 ? 338 ASP A CG  1 
ATOM   2248 O  OD1 . ASP A 1 344 ? -39.079 -6.833  -22.943 1.00 40.83 ? 338 ASP A OD1 1 
ATOM   2249 O  OD2 . ASP A 1 344 ? -39.112 -5.062  -24.236 1.00 35.41 ? 338 ASP A OD2 1 
ATOM   2250 N  N   . GLY A 1 345 ? -40.736 -9.376  -22.232 1.00 38.88 ? 339 GLY A N   1 
ATOM   2251 C  CA  . GLY A 1 345 ? -40.067 -10.649 -22.366 1.00 36.57 ? 339 GLY A CA  1 
ATOM   2252 C  C   . GLY A 1 345 ? -38.554 -10.573 -22.392 1.00 34.00 ? 339 GLY A C   1 
ATOM   2253 O  O   . GLY A 1 345 ? -37.891 -11.594 -22.162 1.00 30.40 ? 339 GLY A O   1 
ATOM   2254 N  N   . GLY A 1 346 ? -37.991 -9.392  -22.654 1.00 33.14 ? 340 GLY A N   1 
ATOM   2255 C  CA  . GLY A 1 346 ? -36.555 -9.214  -22.687 1.00 32.44 ? 340 GLY A CA  1 
ATOM   2256 C  C   . GLY A 1 346 ? -35.976 -8.900  -21.314 1.00 31.22 ? 340 GLY A C   1 
ATOM   2257 O  O   . GLY A 1 346 ? -36.679 -8.830  -20.309 1.00 30.07 ? 340 GLY A O   1 
ATOM   2258 N  N   . PHE A 1 347 ? -34.651 -8.715  -21.296 1.00 30.46 ? 341 PHE A N   1 
ATOM   2259 C  CA  . PHE A 1 347 ? -33.838 -8.439  -20.120 1.00 28.41 ? 341 PHE A CA  1 
ATOM   2260 C  C   . PHE A 1 347 ? -32.929 -7.246  -20.373 1.00 30.20 ? 341 PHE A C   1 
ATOM   2261 O  O   . PHE A 1 347 ? -32.332 -7.147  -21.454 1.00 29.39 ? 341 PHE A O   1 
ATOM   2262 C  CB  . PHE A 1 347 ? -32.962 -9.646  -19.761 1.00 24.66 ? 341 PHE A CB  1 
ATOM   2263 C  CG  . PHE A 1 347 ? -33.715 -10.766 -19.143 1.00 28.66 ? 341 PHE A CG  1 
ATOM   2264 C  CD1 . PHE A 1 347 ? -34.468 -11.622 -19.929 1.00 27.56 ? 341 PHE A CD1 1 
ATOM   2265 C  CD2 . PHE A 1 347 ? -33.694 -10.955 -17.772 1.00 23.75 ? 341 PHE A CD2 1 
ATOM   2266 C  CE1 . PHE A 1 347 ? -35.167 -12.650 -19.360 1.00 27.25 ? 341 PHE A CE1 1 
ATOM   2267 C  CE2 . PHE A 1 347 ? -34.393 -11.979 -17.199 1.00 20.89 ? 341 PHE A CE2 1 
ATOM   2268 C  CZ  . PHE A 1 347 ? -35.122 -12.830 -17.985 1.00 25.73 ? 341 PHE A CZ  1 
ATOM   2269 N  N   . PRO A 1 348 ? -32.774 -6.336  -19.384 1.00 30.95 ? 342 PRO A N   1 
ATOM   2270 C  CA  . PRO A 1 348 ? -31.800 -5.244  -19.522 1.00 29.99 ? 342 PRO A CA  1 
ATOM   2271 C  C   . PRO A 1 348 ? -30.410 -5.672  -19.083 1.00 27.10 ? 342 PRO A C   1 
ATOM   2272 O  O   . PRO A 1 348 ? -30.219 -6.828  -18.710 1.00 27.62 ? 342 PRO A O   1 
ATOM   2273 C  CB  . PRO A 1 348 ? -32.362 -4.156  -18.596 1.00 29.66 ? 342 PRO A CB  1 
ATOM   2274 C  CG  . PRO A 1 348 ? -33.076 -4.907  -17.544 1.00 30.69 ? 342 PRO A CG  1 
ATOM   2275 C  CD  . PRO A 1 348 ? -33.551 -6.222  -18.140 1.00 31.70 ? 342 PRO A CD  1 
ATOM   2276 N  N   . THR A 1 349 ? -29.441 -4.756  -19.099 1.00 26.25 ? 343 THR A N   1 
ATOM   2277 C  CA  . THR A 1 349 ? -28.110 -5.068  -18.588 1.00 27.80 ? 343 THR A CA  1 
ATOM   2278 C  C   . THR A 1 349 ? -28.033 -4.901  -17.072 1.00 30.58 ? 343 THR A C   1 
ATOM   2279 O  O   . THR A 1 349 ? -27.473 -5.755  -16.376 1.00 30.90 ? 343 THR A O   1 
ATOM   2280 C  CB  . THR A 1 349 ? -27.066 -4.171  -19.254 1.00 28.29 ? 343 THR A CB  1 
ATOM   2281 O  OG1 . THR A 1 349 ? -27.118 -4.342  -20.670 1.00 30.65 ? 343 THR A OG1 1 
ATOM   2282 C  CG2 . THR A 1 349 ? -25.666 -4.519  -18.762 1.00 28.78 ? 343 THR A CG2 1 
ATOM   2283 N  N   . PHE A 1 350 ? -28.574 -3.803  -16.549 1.00 26.16 ? 344 PHE A N   1 
ATOM   2284 C  CA  . PHE A 1 350 ? -28.354 -3.348  -15.183 1.00 30.69 ? 344 PHE A CA  1 
ATOM   2285 C  C   . PHE A 1 350 ? -29.638 -3.179  -14.388 1.00 34.06 ? 344 PHE A C   1 
ATOM   2286 O  O   . PHE A 1 350 ? -29.648 -3.422  -13.182 1.00 29.02 ? 344 PHE A O   1 
ATOM   2287 C  CB  . PHE A 1 350 ? -27.638 -1.976  -15.165 1.00 28.83 ? 344 PHE A CB  1 
ATOM   2288 C  CG  . PHE A 1 350 ? -26.277 -1.954  -15.801 1.00 29.88 ? 344 PHE A CG  1 
ATOM   2289 C  CD1 . PHE A 1 350 ? -25.193 -2.586  -15.203 1.00 31.53 ? 344 PHE A CD1 1 
ATOM   2290 C  CD2 . PHE A 1 350 ? -26.059 -1.238  -16.958 1.00 29.40 ? 344 PHE A CD2 1 
ATOM   2291 C  CE1 . PHE A 1 350 ? -23.924 -2.518  -15.775 1.00 28.10 ? 344 PHE A CE1 1 
ATOM   2292 C  CE2 . PHE A 1 350 ? -24.803 -1.190  -17.540 1.00 30.38 ? 344 PHE A CE2 1 
ATOM   2293 C  CZ  . PHE A 1 350 ? -23.738 -1.823  -16.945 1.00 29.69 ? 344 PHE A CZ  1 
ATOM   2294 N  N   . ALA A 1 351 ? -30.707 -2.695  -15.016 1.00 35.87 ? 345 ALA A N   1 
ATOM   2295 C  CA  . ALA A 1 351 ? -31.843 -2.198  -14.256 1.00 35.60 ? 345 ALA A CA  1 
ATOM   2296 C  C   . ALA A 1 351 ? -33.107 -2.367  -15.078 1.00 39.78 ? 345 ALA A C   1 
ATOM   2297 O  O   . ALA A 1 351 ? -33.109 -2.105  -16.286 1.00 44.30 ? 345 ALA A O   1 
ATOM   2298 C  CB  . ALA A 1 351 ? -31.650 -0.730  -13.872 1.00 37.97 ? 345 ALA A CB  1 
ATOM   2299 N  N   . ARG A 1 352 ? -34.168 -2.824  -14.417 1.00 44.86 ? 346 ARG A N   1 
ATOM   2300 C  CA  . ARG A 1 352 ? -35.465 -2.933  -15.067 1.00 42.42 ? 346 ARG A CA  1 
ATOM   2301 C  C   . ARG A 1 352 ? -35.932 -1.550  -15.515 1.00 47.20 ? 346 ARG A C   1 
ATOM   2302 O  O   . ARG A 1 352 ? -35.444 -0.512  -15.050 1.00 45.01 ? 346 ARG A O   1 
ATOM   2303 C  CB  . ARG A 1 352 ? -36.484 -3.568  -14.115 1.00 43.37 ? 346 ARG A CB  1 
ATOM   2304 C  CG  . ARG A 1 352 ? -37.792 -4.005  -14.763 1.00 39.87 ? 346 ARG A CG  1 
ATOM   2305 C  CD  . ARG A 1 352 ? -38.139 -5.438  -14.394 1.00 42.20 ? 346 ARG A CD  1 
ATOM   2306 N  NE  . ARG A 1 352 ? -38.590 -5.587  -13.013 1.00 44.28 ? 346 ARG A NE  1 
ATOM   2307 C  CZ  . ARG A 1 352 ? -39.220 -6.656  -12.530 1.00 45.52 ? 346 ARG A CZ  1 
ATOM   2308 N  NH1 . ARG A 1 352 ? -39.515 -7.696  -13.298 1.00 45.04 ? 346 ARG A NH1 1 
ATOM   2309 N  NH2 . ARG A 1 352 ? -39.542 -6.694  -11.236 1.00 45.35 ? 346 ARG A NH2 1 
ATOM   2310 N  N   . GLY A 1 353 ? -36.883 -1.541  -16.444 1.00 45.79 ? 347 GLY A N   1 
ATOM   2311 C  CA  . GLY A 1 353 ? -37.364 -0.296  -16.996 1.00 43.46 ? 347 GLY A CA  1 
ATOM   2312 C  C   . GLY A 1 353 ? -36.447 0.337   -18.008 1.00 48.15 ? 347 GLY A C   1 
ATOM   2313 O  O   . GLY A 1 353 ? -36.864 1.279   -18.695 1.00 54.65 ? 347 GLY A O   1 
ATOM   2314 N  N   . THR A 1 354 ? -35.211 -0.127  -18.125 1.00 42.78 ? 348 THR A N   1 
ATOM   2315 C  CA  . THR A 1 354 ? -34.359 0.302   -19.221 1.00 47.71 ? 348 THR A CA  1 
ATOM   2316 C  C   . THR A 1 354 ? -34.432 -0.731  -20.348 1.00 42.98 ? 348 THR A C   1 
ATOM   2317 O  O   . THR A 1 354 ? -34.841 -1.880  -20.149 1.00 40.55 ? 348 THR A O   1 
ATOM   2318 C  CB  . THR A 1 354 ? -32.923 0.524   -18.735 1.00 40.98 ? 348 THR A CB  1 
ATOM   2319 O  OG1 . THR A 1 354 ? -32.188 -0.701  -18.809 1.00 50.21 ? 348 THR A OG1 1 
ATOM   2320 C  CG2 . THR A 1 354 ? -32.935 0.993   -17.286 1.00 50.07 ? 348 THR A CG2 1 
ATOM   2321 N  N   . SER A 1 355 ? -34.067 -0.292  -21.548 1.00 36.76 ? 349 SER A N   1 
ATOM   2322 C  CA  . SER A 1 355 ? -34.293 -1.087  -22.752 1.00 38.28 ? 349 SER A CA  1 
ATOM   2323 C  C   . SER A 1 355 ? -33.749 -2.514  -22.604 1.00 37.18 ? 349 SER A C   1 
ATOM   2324 O  O   . SER A 1 355 ? -32.580 -2.718  -22.256 1.00 34.32 ? 349 SER A O   1 
ATOM   2325 C  CB  . SER A 1 355 ? -33.647 -0.371  -23.947 1.00 36.73 ? 349 SER A CB  1 
ATOM   2326 O  OG  . SER A 1 355 ? -33.606 -1.190  -25.104 1.00 39.59 ? 349 SER A OG  1 
ATOM   2327 N  N   . SER A 1 356 ? -34.615 -3.508  -22.838 1.00 35.92 ? 350 SER A N   1 
ATOM   2328 C  CA  . SER A 1 356 ? -34.132 -4.873  -22.994 1.00 30.23 ? 350 SER A CA  1 
ATOM   2329 C  C   . SER A 1 356 ? -33.096 -4.909  -24.107 1.00 32.93 ? 350 SER A C   1 
ATOM   2330 O  O   . SER A 1 356 ? -33.129 -4.102  -25.040 1.00 34.48 ? 350 SER A O   1 
ATOM   2331 C  CB  . SER A 1 356 ? -35.269 -5.833  -23.331 1.00 29.27 ? 350 SER A CB  1 
ATOM   2332 O  OG  . SER A 1 356 ? -36.208 -5.947  -22.281 1.00 32.61 ? 350 SER A OG  1 
ATOM   2333 N  N   . GLU A 1 357 ? -32.162 -5.840  -24.004 1.00 29.61 ? 351 GLU A N   1 
ATOM   2334 C  CA  . GLU A 1 357 ? -31.154 -6.009  -25.037 1.00 35.35 ? 351 GLU A CA  1 
ATOM   2335 C  C   . GLU A 1 357 ? -31.167 -7.452  -25.521 1.00 29.19 ? 351 GLU A C   1 
ATOM   2336 O  O   . GLU A 1 357 ? -31.500 -8.370  -24.769 1.00 31.07 ? 351 GLU A O   1 
ATOM   2337 C  CB  . GLU A 1 357 ? -29.759 -5.610  -24.524 1.00 36.73 ? 351 GLU A CB  1 
ATOM   2338 C  CG  . GLU A 1 357 ? -29.702 -4.205  -23.924 1.00 38.50 ? 351 GLU A CG  1 
ATOM   2339 C  CD  . GLU A 1 357 ? -28.273 -3.763  -23.581 1.00 48.86 ? 351 GLU A CD  1 
ATOM   2340 O  OE1 . GLU A 1 357 ? -27.317 -4.403  -24.086 1.00 51.19 ? 351 GLU A OE1 1 
ATOM   2341 O  OE2 . GLU A 1 357 ? -28.108 -2.778  -22.810 1.00 44.92 ? 351 GLU A OE2 1 
ATOM   2342 N  N   . ILE A 1 358 ? -30.814 -7.638  -26.793 1.00 28.63 ? 352 ILE A N   1 
ATOM   2343 C  CA  . ILE A 1 358 ? -30.901 -8.960  -27.410 1.00 32.18 ? 352 ILE A CA  1 
ATOM   2344 C  C   . ILE A 1 358 ? -29.950 -9.927  -26.733 1.00 26.58 ? 352 ILE A C   1 
ATOM   2345 O  O   . ILE A 1 358 ? -30.353 -10.997 -26.256 1.00 24.85 ? 352 ILE A O   1 
ATOM   2346 C  CB  . ILE A 1 358 ? -30.609 -8.879  -28.916 1.00 30.76 ? 352 ILE A CB  1 
ATOM   2347 C  CG1 . ILE A 1 358 ? -31.603 -7.942  -29.569 1.00 35.60 ? 352 ILE A CG1 1 
ATOM   2348 C  CG2 . ILE A 1 358 ? -30.691 -10.268 -29.525 1.00 24.56 ? 352 ILE A CG2 1 
ATOM   2349 C  CD1 . ILE A 1 358 ? -33.004 -8.442  -29.408 1.00 36.98 ? 352 ILE A CD1 1 
ATOM   2350 N  N   . ALA A 1 359 ? -28.662 -9.572  -26.711 1.00 28.83 ? 353 ALA A N   1 
ATOM   2351 C  CA  . ALA A 1 359 ? -27.658 -10.447 -26.114 1.00 27.01 ? 353 ALA A CA  1 
ATOM   2352 C  C   . ALA A 1 359 ? -27.952 -10.706 -24.641 1.00 20.89 ? 353 ALA A C   1 
ATOM   2353 O  O   . ALA A 1 359 ? -27.826 -11.840 -24.176 1.00 27.47 ? 353 ALA A O   1 
ATOM   2354 C  CB  . ALA A 1 359 ? -26.266 -9.838  -26.297 1.00 26.97 ? 353 ALA A CB  1 
ATOM   2355 N  N   . MET A 1 360 ? -28.355 -9.671  -23.893 1.00 23.42 ? 354 MET A N   1 
ATOM   2356 C  CA  . MET A 1 360 ? -28.711 -9.862  -22.483 1.00 25.93 ? 354 MET A CA  1 
ATOM   2357 C  C   . MET A 1 360 ? -29.892 -10.816 -22.343 1.00 25.66 ? 354 MET A C   1 
ATOM   2358 O  O   . MET A 1 360 ? -29.940 -11.642 -21.418 1.00 22.25 ? 354 MET A O   1 
ATOM   2359 C  CB  . MET A 1 360 ? -29.062 -8.521  -21.828 1.00 24.65 ? 354 MET A CB  1 
ATOM   2360 C  CG  . MET A 1 360 ? -27.925 -7.517  -21.690 1.00 27.90 ? 354 MET A CG  1 
ATOM   2361 S  SD  . MET A 1 360 ? -26.440 -8.154  -20.889 1.00 29.55 ? 354 MET A SD  1 
ATOM   2362 C  CE  . MET A 1 360 ? -25.554 -8.843  -22.293 1.00 30.11 ? 354 MET A CE  1 
ATOM   2363 N  N   . THR A 1 361 ? -30.865 -10.698 -23.247 1.00 23.08 ? 355 THR A N   1 
ATOM   2364 C  CA  . THR A 1 361 ? -32.042 -11.558 -23.210 1.00 24.88 ? 355 THR A CA  1 
ATOM   2365 C  C   . THR A 1 361 ? -31.700 -12.981 -23.617 1.00 20.98 ? 355 THR A C   1 
ATOM   2366 O  O   . THR A 1 361 ? -32.203 -13.938 -23.022 1.00 22.22 ? 355 THR A O   1 
ATOM   2367 C  CB  . THR A 1 361 ? -33.121 -10.986 -24.121 1.00 25.28 ? 355 THR A CB  1 
ATOM   2368 O  OG1 . THR A 1 361 ? -33.436 -9.656  -23.687 1.00 27.75 ? 355 THR A OG1 1 
ATOM   2369 C  CG2 . THR A 1 361 ? -34.379 -11.852 -24.069 1.00 25.71 ? 355 THR A CG2 1 
ATOM   2370 N  N   . ALA A 1 362 ? -30.859 -13.137 -24.642 1.00 20.93 ? 356 ALA A N   1 
ATOM   2371 C  CA  . ALA A 1 362 ? -30.374 -14.459 -25.016 1.00 21.70 ? 356 ALA A CA  1 
ATOM   2372 C  C   . ALA A 1 362 ? -29.565 -15.091 -23.886 1.00 21.68 ? 356 ALA A C   1 
ATOM   2373 O  O   . ALA A 1 362 ? -29.736 -16.276 -23.581 1.00 18.70 ? 356 ALA A O   1 
ATOM   2374 C  CB  . ALA A 1 362 ? -29.540 -14.365 -26.299 1.00 23.22 ? 356 ALA A CB  1 
ATOM   2375 N  N   . ALA A 1 363 ? -28.687 -14.313 -23.244 1.00 24.03 ? 357 ALA A N   1 
ATOM   2376 C  CA  . ALA A 1 363 ? -27.878 -14.868 -22.158 1.00 24.03 ? 357 ALA A CA  1 
ATOM   2377 C  C   . ALA A 1 363 ? -28.750 -15.331 -21.000 1.00 22.08 ? 357 ALA A C   1 
ATOM   2378 O  O   . ALA A 1 363 ? -28.496 -16.390 -20.410 1.00 20.23 ? 357 ALA A O   1 
ATOM   2379 C  CB  . ALA A 1 363 ? -26.845 -13.841 -21.677 1.00 21.20 ? 357 ALA A CB  1 
ATOM   2380 N  N   . ALA A 1 364 ? -29.787 -14.560 -20.655 1.00 21.16 ? 358 ALA A N   1 
ATOM   2381 C  CA  . ALA A 1 364 ? -30.627 -14.955 -19.526 1.00 21.53 ? 358 ALA A CA  1 
ATOM   2382 C  C   . ALA A 1 364 ? -31.501 -16.161 -19.860 1.00 23.01 ? 358 ALA A C   1 
ATOM   2383 O  O   . ALA A 1 364 ? -31.819 -16.953 -18.970 1.00 22.90 ? 358 ALA A O   1 
ATOM   2384 C  CB  . ALA A 1 364 ? -31.491 -13.788 -19.055 1.00 17.78 ? 358 ALA A CB  1 
ATOM   2385 N  N   . ALA A 1 365 ? -31.881 -16.328 -21.128 1.00 29.92 ? 359 ALA A N   1 
ATOM   2386 C  CA  . ALA A 1 365 ? -32.663 -17.500 -21.528 1.00 22.96 ? 359 ALA A CA  1 
ATOM   2387 C  C   . ALA A 1 365 ? -31.868 -18.787 -21.362 1.00 23.03 ? 359 ALA A C   1 
ATOM   2388 O  O   . ALA A 1 365 ? -32.370 -19.774 -20.804 1.00 24.86 ? 359 ALA A O   1 
ATOM   2389 C  CB  . ALA A 1 365 ? -33.125 -17.341 -22.977 1.00 23.74 ? 359 ALA A CB  1 
ATOM   2390 N  N   . SER A 1 366 ? -30.634 -18.812 -21.871 1.00 23.78 ? 360 SER A N   1 
ATOM   2391 C  CA  . SER A 1 366 ? -29.768 -19.973 -21.665 1.00 21.37 ? 360 SER A CA  1 
ATOM   2392 C  C   . SER A 1 366 ? -29.542 -20.231 -20.180 1.00 26.93 ? 360 SER A C   1 
ATOM   2393 O  O   . SER A 1 366 ? -29.631 -21.375 -19.715 1.00 26.95 ? 360 SER A O   1 
ATOM   2394 C  CB  . SER A 1 366 ? -28.423 -19.767 -22.359 1.00 23.84 ? 360 SER A CB  1 
ATOM   2395 O  OG  . SER A 1 366 ? -28.561 -19.717 -23.772 1.00 30.27 ? 360 SER A OG  1 
ATOM   2396 N  N   . ALA A 1 367 ? -29.250 -19.176 -19.418 1.00 22.90 ? 361 ALA A N   1 
ATOM   2397 C  CA  . ALA A 1 367 ? -28.892 -19.361 -18.016 1.00 28.09 ? 361 ALA A CA  1 
ATOM   2398 C  C   . ALA A 1 367 ? -30.066 -19.867 -17.191 1.00 27.41 ? 361 ALA A C   1 
ATOM   2399 O  O   . ALA A 1 367 ? -29.862 -20.614 -16.233 1.00 32.65 ? 361 ALA A O   1 
ATOM   2400 C  CB  . ALA A 1 367 ? -28.357 -18.053 -17.426 1.00 24.89 ? 361 ALA A CB  1 
ATOM   2401 N  N   . LEU A 1 368 ? -31.292 -19.461 -17.519 1.00 30.56 ? 362 LEU A N   1 
ATOM   2402 C  CA  . LEU A 1 368 ? -32.450 -19.907 -16.757 1.00 31.28 ? 362 LEU A CA  1 
ATOM   2403 C  C   . LEU A 1 368 ? -33.099 -21.166 -17.321 1.00 40.93 ? 362 LEU A C   1 
ATOM   2404 O  O   . LEU A 1 368 ? -34.073 -21.654 -16.730 1.00 43.01 ? 362 LEU A O   1 
ATOM   2405 C  CB  . LEU A 1 368 ? -33.500 -18.790 -16.631 1.00 29.45 ? 362 LEU A CB  1 
ATOM   2406 C  CG  . LEU A 1 368 ? -33.081 -17.466 -15.953 1.00 26.98 ? 362 LEU A CG  1 
ATOM   2407 C  CD1 . LEU A 1 368 ? -33.876 -16.230 -16.396 1.00 22.79 ? 362 LEU A CD1 1 
ATOM   2408 C  CD2 . LEU A 1 368 ? -33.146 -17.647 -14.442 1.00 26.53 ? 362 LEU A CD2 1 
ATOM   2409 N  N   . ALA A 1 369 ? -32.571 -21.721 -18.418 1.00 32.65 ? 363 ALA A N   1 
ATOM   2410 C  CA  . ALA A 1 369 ? -33.194 -22.891 -19.025 1.00 37.98 ? 363 ALA A CA  1 
ATOM   2411 C  C   . ALA A 1 369 ? -33.018 -24.138 -18.170 1.00 46.57 ? 363 ALA A C   1 
ATOM   2412 O  O   . ALA A 1 369 ? -33.854 -25.045 -18.232 1.00 50.00 ? 363 ALA A O   1 
ATOM   2413 C  CB  . ALA A 1 369 ? -32.624 -23.128 -20.426 1.00 32.43 ? 363 ALA A CB  1 
ATOM   2414 N  N   . HIS A 1 370 ? -31.952 -24.204 -17.365 1.00 47.94 ? 364 HIS A N   1 
ATOM   2415 C  CA  . HIS A 1 370 ? -31.640 -25.441 -16.648 1.00 52.90 ? 364 HIS A CA  1 
ATOM   2416 C  C   . HIS A 1 370 ? -32.818 -25.904 -15.800 1.00 52.95 ? 364 HIS A C   1 
ATOM   2417 O  O   . HIS A 1 370 ? -33.248 -27.059 -15.893 1.00 55.80 ? 364 HIS A O   1 
ATOM   2418 C  CB  . HIS A 1 370 ? -30.395 -25.251 -15.779 1.00 51.40 ? 364 HIS A CB  1 
ATOM   2419 C  CG  . HIS A 1 370 ? -29.139 -25.068 -16.571 1.00 54.81 ? 364 HIS A CG  1 
ATOM   2420 N  ND1 . HIS A 1 370 ? -28.422 -23.888 -16.572 1.00 54.92 ? 364 HIS A ND1 1 
ATOM   2421 C  CD2 . HIS A 1 370 ? -28.484 -25.909 -17.407 1.00 54.51 ? 364 HIS A CD2 1 
ATOM   2422 C  CE1 . HIS A 1 370 ? -27.375 -24.014 -17.370 1.00 50.43 ? 364 HIS A CE1 1 
ATOM   2423 N  NE2 . HIS A 1 370 ? -27.390 -25.230 -17.889 1.00 57.16 ? 364 HIS A NE2 1 
ATOM   2424 N  N   . ASP A 1 371 ? -33.352 -25.017 -14.970 1.00 54.16 ? 365 ASP A N   1 
ATOM   2425 C  CA  . ASP A 1 371 ? -34.522 -25.350 -14.160 1.00 55.64 ? 365 ASP A CA  1 
ATOM   2426 C  C   . ASP A 1 371 ? -35.782 -25.374 -15.021 1.00 53.58 ? 365 ASP A C   1 
ATOM   2427 O  O   . ASP A 1 371 ? -36.060 -24.399 -15.728 1.00 50.40 ? 365 ASP A O   1 
ATOM   2428 C  CB  . ASP A 1 371 ? -34.680 -24.335 -13.033 1.00 56.60 ? 365 ASP A CB  1 
ATOM   2429 C  CG  . ASP A 1 371 ? -35.758 -24.721 -12.061 1.00 60.67 ? 365 ASP A CG  1 
ATOM   2430 O  OD1 . ASP A 1 371 ? -35.489 -25.552 -11.168 1.00 72.06 ? 365 ASP A OD1 1 
ATOM   2431 O  OD2 . ASP A 1 371 ? -36.878 -24.192 -12.190 1.00 59.14 ? 365 ASP A OD2 1 
ATOM   2432 N  N   . PRO A 1 372 ? -36.578 -26.453 -14.978 1.00 57.12 ? 366 PRO A N   1 
ATOM   2433 C  CA  . PRO A 1 372 ? -37.806 -26.495 -15.791 1.00 51.09 ? 366 PRO A CA  1 
ATOM   2434 C  C   . PRO A 1 372 ? -38.904 -25.593 -15.273 1.00 52.31 ? 366 PRO A C   1 
ATOM   2435 O  O   . PRO A 1 372 ? -39.866 -25.342 -16.009 1.00 49.60 ? 366 PRO A O   1 
ATOM   2436 C  CB  . PRO A 1 372 ? -38.232 -27.973 -15.724 1.00 55.36 ? 366 PRO A CB  1 
ATOM   2437 C  CG  . PRO A 1 372 ? -37.078 -28.717 -15.051 1.00 54.17 ? 366 PRO A CG  1 
ATOM   2438 C  CD  . PRO A 1 372 ? -36.383 -27.693 -14.207 1.00 60.83 ? 366 PRO A CD  1 
ATOM   2439 N  N   . ASP A 1 373 ? -38.781 -25.092 -14.040 1.00 56.65 ? 367 ASP A N   1 
ATOM   2440 C  CA  . ASP A 1 373 ? -39.778 -24.221 -13.426 1.00 55.38 ? 367 ASP A CA  1 
ATOM   2441 C  C   . ASP A 1 373 ? -39.833 -22.823 -14.044 1.00 52.15 ? 367 ASP A C   1 
ATOM   2442 O  O   . ASP A 1 373 ? -40.790 -22.086 -13.776 1.00 49.29 ? 367 ASP A O   1 
ATOM   2443 C  CB  . ASP A 1 373 ? -39.504 -24.131 -11.920 1.00 59.47 ? 367 ASP A CB  1 
ATOM   2444 C  CG  . ASP A 1 373 ? -40.727 -23.710 -11.123 1.00 67.63 ? 367 ASP A CG  1 
ATOM   2445 O  OD1 . ASP A 1 373 ? -41.765 -24.401 -11.238 1.00 66.27 ? 367 ASP A OD1 1 
ATOM   2446 O  OD2 . ASP A 1 373 ? -40.657 -22.684 -10.403 1.00 63.19 ? 367 ASP A OD2 1 
ATOM   2447 N  N   . ARG A 1 374 ? -38.863 -22.439 -14.879 1.00 54.16 ? 368 ARG A N   1 
ATOM   2448 C  CA  . ARG A 1 374 ? -38.872 -21.123 -15.512 1.00 46.69 ? 368 ARG A CA  1 
ATOM   2449 C  C   . ARG A 1 374 ? -39.192 -21.201 -17.000 1.00 46.38 ? 368 ARG A C   1 
ATOM   2450 O  O   . ARG A 1 374 ? -38.904 -20.253 -17.742 1.00 42.11 ? 368 ARG A O   1 
ATOM   2451 C  CB  . ARG A 1 374 ? -37.532 -20.418 -15.300 1.00 47.23 ? 368 ARG A CB  1 
ATOM   2452 C  CG  . ARG A 1 374 ? -37.318 -19.892 -13.902 1.00 45.75 ? 368 ARG A CG  1 
ATOM   2453 C  CD  . ARG A 1 374 ? -37.117 -21.041 -12.934 1.00 52.65 ? 368 ARG A CD  1 
ATOM   2454 N  NE  . ARG A 1 374 ? -36.277 -20.646 -11.814 1.00 51.43 ? 368 ARG A NE  1 
ATOM   2455 C  CZ  . ARG A 1 374 ? -36.732 -20.016 -10.742 1.00 52.87 ? 368 ARG A CZ  1 
ATOM   2456 N  NH1 . ARG A 1 374 ? -38.009 -19.675 -10.633 1.00 48.06 ? 368 ARG A NH1 1 
ATOM   2457 N  NH2 . ARG A 1 374 ? -35.886 -19.711 -9.760  1.00 51.23 ? 368 ARG A NH2 1 
ATOM   2458 N  N   . ARG A 1 375 ? -39.787 -22.314 -17.449 1.00 48.10 ? 369 ARG A N   1 
ATOM   2459 C  CA  . ARG A 1 375 ? -40.082 -22.499 -18.870 1.00 44.04 ? 369 ARG A CA  1 
ATOM   2460 C  C   . ARG A 1 375 ? -40.829 -21.311 -19.460 1.00 40.32 ? 369 ARG A C   1 
ATOM   2461 O  O   . ARG A 1 375 ? -40.561 -20.899 -20.595 1.00 41.51 ? 369 ARG A O   1 
ATOM   2462 C  CB  . ARG A 1 375 ? -40.896 -23.777 -19.075 1.00 51.48 ? 369 ARG A CB  1 
ATOM   2463 C  CG  . ARG A 1 375 ? -40.047 -25.011 -19.131 1.00 53.13 ? 369 ARG A CG  1 
ATOM   2464 C  CD  . ARG A 1 375 ? -39.706 -25.343 -20.570 1.00 54.73 ? 369 ARG A CD  1 
ATOM   2465 N  NE  . ARG A 1 375 ? -38.371 -24.862 -20.909 1.00 59.27 ? 369 ARG A NE  1 
ATOM   2466 C  CZ  . ARG A 1 375 ? -37.258 -25.568 -20.757 1.00 67.10 ? 369 ARG A CZ  1 
ATOM   2467 N  NH1 . ARG A 1 375 ? -37.278 -26.795 -20.253 1.00 59.01 ? 369 ARG A NH1 1 
ATOM   2468 N  NH2 . ARG A 1 375 ? -36.095 -25.031 -21.119 1.00 63.29 ? 369 ARG A NH2 1 
ATOM   2469 N  N   . GLU A 1 376 ? -41.776 -20.751 -18.706 1.00 39.34 ? 370 GLU A N   1 
ATOM   2470 C  CA  . GLU A 1 376 ? -42.593 -19.671 -19.245 1.00 40.77 ? 370 GLU A CA  1 
ATOM   2471 C  C   . GLU A 1 376 ? -41.767 -18.409 -19.453 1.00 43.42 ? 370 GLU A C   1 
ATOM   2472 O  O   . GLU A 1 376 ? -41.969 -17.681 -20.436 1.00 40.13 ? 370 GLU A O   1 
ATOM   2473 C  CB  . GLU A 1 376 ? -43.778 -19.418 -18.318 1.00 40.02 ? 370 GLU A CB  1 
ATOM   2474 C  CG  . GLU A 1 376 ? -44.366 -18.028 -18.368 1.00 48.55 ? 370 GLU A CG  1 
ATOM   2475 C  CD  . GLU A 1 376 ? -45.501 -17.841 -17.353 1.00 56.79 ? 370 GLU A CD  1 
ATOM   2476 O  OE1 . GLU A 1 376 ? -45.233 -17.894 -16.130 1.00 55.74 ? 370 GLU A OE1 1 
ATOM   2477 O  OE2 . GLU A 1 376 ? -46.663 -17.648 -17.776 1.00 59.34 ? 370 GLU A OE2 1 
ATOM   2478 N  N   . GLU A 1 377 ? -40.822 -18.135 -18.546 1.00 41.55 ? 371 GLU A N   1 
ATOM   2479 C  CA  . GLU A 1 377 ? -39.959 -16.970 -18.729 1.00 38.84 ? 371 GLU A CA  1 
ATOM   2480 C  C   . GLU A 1 377 ? -38.902 -17.236 -19.789 1.00 31.63 ? 371 GLU A C   1 
ATOM   2481 O  O   . GLU A 1 377 ? -38.561 -16.339 -20.564 1.00 29.15 ? 371 GLU A O   1 
ATOM   2482 C  CB  . GLU A 1 377 ? -39.298 -16.576 -17.405 1.00 40.57 ? 371 GLU A CB  1 
ATOM   2483 C  CG  . GLU A 1 377 ? -40.249 -15.942 -16.375 1.00 42.83 ? 371 GLU A CG  1 
ATOM   2484 C  CD  . GLU A 1 377 ? -40.916 -16.981 -15.482 1.00 44.10 ? 371 GLU A CD  1 
ATOM   2485 O  OE1 . GLU A 1 377 ? -40.715 -18.195 -15.725 1.00 51.48 ? 371 GLU A OE1 1 
ATOM   2486 O  OE2 . GLU A 1 377 ? -41.626 -16.591 -14.532 1.00 49.02 ? 371 GLU A OE2 1 
ATOM   2487 N  N   . VAL A 1 378 ? -38.384 -18.462 -19.847 1.00 33.49 ? 372 VAL A N   1 
ATOM   2488 C  CA  . VAL A 1 378 ? -37.373 -18.787 -20.849 1.00 29.05 ? 372 VAL A CA  1 
ATOM   2489 C  C   . VAL A 1 378 ? -37.962 -18.669 -22.252 1.00 34.95 ? 372 VAL A C   1 
ATOM   2490 O  O   . VAL A 1 378 ? -37.394 -17.995 -23.126 1.00 27.54 ? 372 VAL A O   1 
ATOM   2491 C  CB  . VAL A 1 378 ? -36.792 -20.182 -20.580 1.00 32.64 ? 372 VAL A CB  1 
ATOM   2492 C  CG1 . VAL A 1 378 ? -35.890 -20.624 -21.716 1.00 33.55 ? 372 VAL A CG1 1 
ATOM   2493 C  CG2 . VAL A 1 378 ? -36.037 -20.175 -19.261 1.00 30.54 ? 372 VAL A CG2 1 
ATOM   2494 N  N   . ASP A 1 379 ? -39.134 -19.284 -22.478 1.00 33.60 ? 373 ASP A N   1 
ATOM   2495 C  CA  . ASP A 1 379 ? -39.750 -19.226 -23.806 1.00 32.43 ? 373 ASP A CA  1 
ATOM   2496 C  C   . ASP A 1 379 ? -40.038 -17.788 -24.230 1.00 33.21 ? 373 ASP A C   1 
ATOM   2497 O  O   . ASP A 1 379 ? -39.794 -17.423 -25.387 1.00 35.35 ? 373 ASP A O   1 
ATOM   2498 C  CB  . ASP A 1 379 ? -41.043 -20.051 -23.854 1.00 32.22 ? 373 ASP A CB  1 
ATOM   2499 C  CG  . ASP A 1 379 ? -40.806 -21.550 -23.777 1.00 34.91 ? 373 ASP A CG  1 
ATOM   2500 O  OD1 . ASP A 1 379 ? -39.794 -22.059 -24.309 1.00 37.30 ? 373 ASP A OD1 1 
ATOM   2501 O  OD2 . ASP A 1 379 ? -41.652 -22.233 -23.170 1.00 48.39 ? 373 ASP A OD2 1 
ATOM   2502 N  N   . GLU A 1 380 ? -40.572 -16.960 -23.316 1.00 28.08 ? 374 GLU A N   1 
ATOM   2503 C  CA  . GLU A 1 380 ? -40.835 -15.558 -23.654 1.00 33.28 ? 374 GLU A CA  1 
ATOM   2504 C  C   . GLU A 1 380 ? -39.547 -14.832 -24.045 1.00 34.01 ? 374 GLU A C   1 
ATOM   2505 O  O   . GLU A 1 380 ? -39.564 -13.940 -24.905 1.00 34.22 ? 374 GLU A O   1 
ATOM   2506 C  CB  . GLU A 1 380 ? -41.504 -14.826 -22.478 1.00 37.53 ? 374 GLU A CB  1 
ATOM   2507 C  CG  . GLU A 1 380 ? -43.010 -15.077 -22.260 1.00 41.05 ? 374 GLU A CG  1 
ATOM   2508 C  CD  . GLU A 1 380 ? -43.530 -14.479 -20.923 1.00 45.84 ? 374 GLU A CD  1 
ATOM   2509 O  OE1 . GLU A 1 380 ? -43.205 -13.311 -20.599 1.00 44.34 ? 374 GLU A OE1 1 
ATOM   2510 O  OE2 . GLU A 1 380 ? -44.241 -15.198 -20.179 1.00 47.54 ? 374 GLU A OE2 1 
ATOM   2511 N  N   . ALA A 1 381 ? -38.427 -15.172 -23.399 1.00 27.60 ? 375 ALA A N   1 
ATOM   2512 C  CA  . ALA A 1 381 ? -37.145 -14.594 -23.787 1.00 26.99 ? 375 ALA A CA  1 
ATOM   2513 C  C   . ALA A 1 381 ? -36.755 -15.028 -25.200 1.00 26.32 ? 375 ALA A C   1 
ATOM   2514 O  O   . ALA A 1 381 ? -36.389 -14.198 -26.040 1.00 25.85 ? 375 ALA A O   1 
ATOM   2515 C  CB  . ALA A 1 381 ? -36.067 -14.991 -22.777 1.00 24.64 ? 375 ALA A CB  1 
ATOM   2516 N  N   . VAL A 1 382 ? -36.851 -16.327 -25.494 1.00 27.88 ? 376 VAL A N   1 
ATOM   2517 C  CA  . VAL A 1 382 ? -36.445 -16.795 -26.816 1.00 24.85 ? 376 VAL A CA  1 
ATOM   2518 C  C   . VAL A 1 382 ? -37.318 -16.173 -27.901 1.00 26.28 ? 376 VAL A C   1 
ATOM   2519 O  O   . VAL A 1 382 ? -36.832 -15.863 -28.997 1.00 30.46 ? 376 VAL A O   1 
ATOM   2520 C  CB  . VAL A 1 382 ? -36.460 -18.330 -26.854 1.00 28.52 ? 376 VAL A CB  1 
ATOM   2521 C  CG1 . VAL A 1 382 ? -36.402 -18.831 -28.272 1.00 27.33 ? 376 VAL A CG1 1 
ATOM   2522 C  CG2 . VAL A 1 382 ? -35.294 -18.891 -26.035 1.00 25.05 ? 376 VAL A CG2 1 
ATOM   2523 N  N   . ARG A 1 383 ? -38.602 -15.932 -27.608 1.00 31.50 ? 377 ARG A N   1 
ATOM   2524 C  CA  . ARG A 1 383 ? -39.480 -15.292 -28.586 1.00 31.75 ? 377 ARG A CA  1 
ATOM   2525 C  C   . ARG A 1 383 ? -39.096 -13.835 -28.794 1.00 30.15 ? 377 ARG A C   1 
ATOM   2526 O  O   . ARG A 1 383 ? -39.218 -13.310 -29.907 1.00 31.77 ? 377 ARG A O   1 
ATOM   2527 C  CB  . ARG A 1 383 ? -40.939 -15.407 -28.143 1.00 30.00 ? 377 ARG A CB  1 
ATOM   2528 C  CG  . ARG A 1 383 ? -41.452 -16.836 -28.081 1.00 36.33 ? 377 ARG A CG  1 
ATOM   2529 C  CD  . ARG A 1 383 ? -42.912 -16.899 -27.646 1.00 41.19 ? 377 ARG A CD  1 
ATOM   2530 N  NE  . ARG A 1 383 ? -43.280 -18.199 -27.085 1.00 37.54 ? 377 ARG A NE  1 
ATOM   2531 C  CZ  . ARG A 1 383 ? -43.856 -18.358 -25.902 1.00 39.30 ? 377 ARG A CZ  1 
ATOM   2532 N  NH1 . ARG A 1 383 ? -44.092 -17.325 -25.104 1.00 44.60 ? 377 ARG A NH1 1 
ATOM   2533 N  NH2 . ARG A 1 383 ? -44.209 -19.580 -25.508 1.00 37.51 ? 377 ARG A NH2 1 
ATOM   2534 N  N   . TYR A 1 384 ? -38.616 -13.169 -27.738 1.00 26.83 ? 378 TYR A N   1 
ATOM   2535 C  CA  . TYR A 1 384 ? -38.084 -11.819 -27.894 1.00 27.22 ? 378 TYR A CA  1 
ATOM   2536 C  C   . TYR A 1 384 ? -36.905 -11.813 -28.860 1.00 28.41 ? 378 TYR A C   1 
ATOM   2537 O  O   . TYR A 1 384 ? -36.786 -10.924 -29.720 1.00 24.88 ? 378 TYR A O   1 
ATOM   2538 C  CB  . TYR A 1 384 ? -37.669 -11.254 -26.528 1.00 28.48 ? 378 TYR A CB  1 
ATOM   2539 C  CG  . TYR A 1 384 ? -37.070 -9.854  -26.598 1.00 29.17 ? 378 TYR A CG  1 
ATOM   2540 C  CD1 . TYR A 1 384 ? -35.753 -9.652  -26.997 1.00 27.85 ? 378 TYR A CD1 1 
ATOM   2541 C  CD2 . TYR A 1 384 ? -37.832 -8.733  -26.285 1.00 31.84 ? 378 TYR A CD2 1 
ATOM   2542 C  CE1 . TYR A 1 384 ? -35.215 -8.375  -27.084 1.00 30.33 ? 378 TYR A CE1 1 
ATOM   2543 C  CE2 . TYR A 1 384 ? -37.298 -7.452  -26.359 1.00 32.42 ? 378 TYR A CE2 1 
ATOM   2544 C  CZ  . TYR A 1 384 ? -35.992 -7.279  -26.753 1.00 33.34 ? 378 TYR A CZ  1 
ATOM   2545 O  OH  . TYR A 1 384 ? -35.461 -6.006  -26.822 1.00 34.26 ? 378 TYR A OH  1 
ATOM   2546 N  N   . VAL A 1 385 ? -36.014 -12.794 -28.728 1.00 27.64 ? 379 VAL A N   1 
ATOM   2547 C  CA  . VAL A 1 385 ? -34.855 -12.867 -29.614 1.00 27.05 ? 379 VAL A CA  1 
ATOM   2548 C  C   . VAL A 1 385 ? -35.305 -13.018 -31.063 1.00 27.47 ? 379 VAL A C   1 
ATOM   2549 O  O   . VAL A 1 385 ? -34.860 -12.283 -31.953 1.00 23.77 ? 379 VAL A O   1 
ATOM   2550 C  CB  . VAL A 1 385 ? -33.933 -14.020 -29.179 1.00 28.47 ? 379 VAL A CB  1 
ATOM   2551 C  CG1 . VAL A 1 385 ? -32.786 -14.196 -30.176 1.00 18.82 ? 379 VAL A CG1 1 
ATOM   2552 C  CG2 . VAL A 1 385 ? -33.405 -13.756 -27.760 1.00 23.42 ? 379 VAL A CG2 1 
ATOM   2553 N  N   . VAL A 1 386 ? -36.203 -13.968 -31.319 1.00 24.81 ? 380 VAL A N   1 
ATOM   2554 C  CA  . VAL A 1 386 ? -36.655 -14.205 -32.687 1.00 25.86 ? 380 VAL A CA  1 
ATOM   2555 C  C   . VAL A 1 386 ? -37.289 -12.948 -33.278 1.00 30.90 ? 380 VAL A C   1 
ATOM   2556 O  O   . VAL A 1 386 ? -36.992 -12.562 -34.411 1.00 32.96 ? 380 VAL A O   1 
ATOM   2557 C  CB  . VAL A 1 386 ? -37.620 -15.405 -32.719 1.00 29.87 ? 380 VAL A CB  1 
ATOM   2558 C  CG1 . VAL A 1 386 ? -38.130 -15.628 -34.143 1.00 34.58 ? 380 VAL A CG1 1 
ATOM   2559 C  CG2 . VAL A 1 386 ? -36.927 -16.663 -32.169 1.00 26.55 ? 380 VAL A CG2 1 
ATOM   2560 N  N   . ARG A 1 387 ? -38.158 -12.278 -32.515 1.00 34.98 ? 381 ARG A N   1 
ATOM   2561 C  CA  . ARG A 1 387 ? -38.833 -11.076 -33.004 1.00 29.80 ? 381 ARG A CA  1 
ATOM   2562 C  C   . ARG A 1 387 ? -37.849 -10.008 -33.455 1.00 33.15 ? 381 ARG A C   1 
ATOM   2563 O  O   . ARG A 1 387 ? -38.168 -9.209  -34.344 1.00 35.46 ? 381 ARG A O   1 
ATOM   2564 C  CB  . ARG A 1 387 ? -39.733 -10.508 -31.902 1.00 30.53 ? 381 ARG A CB  1 
ATOM   2565 C  CG  . ARG A 1 387 ? -41.204 -10.410 -32.260 1.00 34.55 ? 381 ARG A CG  1 
ATOM   2566 C  CD  . ARG A 1 387 ? -42.104 -10.718 -31.063 1.00 32.15 ? 381 ARG A CD  1 
ATOM   2567 N  NE  . ARG A 1 387 ? -41.714 -9.977  -29.869 1.00 32.25 ? 381 ARG A NE  1 
ATOM   2568 C  CZ  . ARG A 1 387 ? -41.632 -10.509 -28.654 1.00 40.49 ? 381 ARG A CZ  1 
ATOM   2569 N  NH1 . ARG A 1 387 ? -41.892 -11.794 -28.439 1.00 34.78 ? 381 ARG A NH1 1 
ATOM   2570 N  NH2 . ARG A 1 387 ? -41.266 -9.740  -27.632 1.00 35.22 ? 381 ARG A NH2 1 
ATOM   2571 N  N   . HIS A 1 388 ? -36.662 -9.951  -32.852 1.00 30.38 ? 382 HIS A N   1 
ATOM   2572 C  CA  . HIS A 1 388 ? -35.741 -8.845  -33.092 1.00 29.45 ? 382 HIS A CA  1 
ATOM   2573 C  C   . HIS A 1 388 ? -34.615 -9.194  -34.059 1.00 24.77 ? 382 HIS A C   1 
ATOM   2574 O  O   . HIS A 1 388 ? -33.705 -8.386  -34.239 1.00 26.29 ? 382 HIS A O   1 
ATOM   2575 C  CB  . HIS A 1 388 ? -35.151 -8.347  -31.763 1.00 29.44 ? 382 HIS A CB  1 
ATOM   2576 C  CG  . HIS A 1 388 ? -36.108 -7.532  -30.953 1.00 33.64 ? 382 HIS A CG  1 
ATOM   2577 N  ND1 . HIS A 1 388 ? -37.067 -8.101  -30.141 1.00 34.75 ? 382 HIS A ND1 1 
ATOM   2578 C  CD2 . HIS A 1 388 ? -36.278 -6.191  -30.856 1.00 31.78 ? 382 HIS A CD2 1 
ATOM   2579 C  CE1 . HIS A 1 388 ? -37.784 -7.146  -29.575 1.00 33.19 ? 382 HIS A CE1 1 
ATOM   2580 N  NE2 . HIS A 1 388 ? -37.321 -5.979  -29.986 1.00 38.76 ? 382 HIS A NE2 1 
ATOM   2581 N  N   . GLN A 1 389 ? -34.633 -10.383 -34.649 1.00 26.45 ? 383 GLN A N   1 
ATOM   2582 C  CA  . GLN A 1 389 ? -33.641 -10.726 -35.660 1.00 27.45 ? 383 GLN A CA  1 
ATOM   2583 C  C   . GLN A 1 389 ? -33.784 -9.777  -36.845 1.00 26.75 ? 383 GLN A C   1 
ATOM   2584 O  O   . GLN A 1 389 ? -34.895 -9.453  -37.260 1.00 20.78 ? 383 GLN A O   1 
ATOM   2585 C  CB  . GLN A 1 389 ? -33.826 -12.182 -36.116 1.00 24.97 ? 383 GLN A CB  1 
ATOM   2586 C  CG  . GLN A 1 389 ? -32.625 -12.777 -36.847 1.00 23.48 ? 383 GLN A CG  1 
ATOM   2587 C  CD  . GLN A 1 389 ? -32.728 -14.287 -37.044 1.00 22.05 ? 383 GLN A CD  1 
ATOM   2588 O  OE1 . GLN A 1 389 ? -33.811 -14.867 -36.962 1.00 26.92 ? 383 GLN A OE1 1 
ATOM   2589 N  NE2 . GLN A 1 389 ? -31.597 -14.926 -37.315 1.00 20.01 ? 383 GLN A NE2 1 
ATOM   2590 N  N   . ARG A 1 390 ? -32.656 -9.316  -37.378 1.00 25.71 ? 384 ARG A N   1 
ATOM   2591 C  CA  . ARG A 1 390 ? -32.701 -8.373  -38.487 1.00 29.12 ? 384 ARG A CA  1 
ATOM   2592 C  C   . ARG A 1 390 ? -32.984 -9.081  -39.814 1.00 28.95 ? 384 ARG A C   1 
ATOM   2593 O  O   . ARG A 1 390 ? -32.834 -10.303 -39.932 1.00 27.39 ? 384 ARG A O   1 
ATOM   2594 C  CB  . ARG A 1 390 ? -31.381 -7.617  -38.588 1.00 29.06 ? 384 ARG A CB  1 
ATOM   2595 C  CG  . ARG A 1 390 ? -30.946 -6.945  -37.290 1.00 34.64 ? 384 ARG A CG  1 
ATOM   2596 C  CD  . ARG A 1 390 ? -30.927 -5.470  -37.394 1.00 33.70 ? 384 ARG A CD  1 
ATOM   2597 N  NE  . ARG A 1 390 ? -29.917 -4.905  -36.507 1.00 50.66 ? 384 ARG A NE  1 
ATOM   2598 C  CZ  . ARG A 1 390 ? -30.072 -3.792  -35.795 1.00 63.74 ? 384 ARG A CZ  1 
ATOM   2599 N  NH1 . ARG A 1 390 ? -31.198 -3.092  -35.835 1.00 59.87 ? 384 ARG A NH1 1 
ATOM   2600 N  NH2 . ARG A 1 390 ? -29.065 -3.362  -35.035 1.00 57.25 ? 384 ARG A NH2 1 
ATOM   2601 N  N   . PRO A 1 391 ? -33.353 -8.314  -40.845 1.00 34.27 ? 385 PRO A N   1 
ATOM   2602 C  CA  . PRO A 1 391 ? -33.644 -8.923  -42.157 1.00 31.40 ? 385 PRO A CA  1 
ATOM   2603 C  C   . PRO A 1 391 ? -32.491 -9.714  -42.741 1.00 29.46 ? 385 PRO A C   1 
ATOM   2604 O  O   . PRO A 1 391 ? -32.734 -10.635 -43.529 1.00 26.55 ? 385 PRO A O   1 
ATOM   2605 C  CB  . PRO A 1 391 ? -33.988 -7.718  -43.047 1.00 30.95 ? 385 PRO A CB  1 
ATOM   2606 C  CG  . PRO A 1 391 ? -34.160 -6.545  -42.120 1.00 32.42 ? 385 PRO A CG  1 
ATOM   2607 C  CD  . PRO A 1 391 ? -33.457 -6.839  -40.853 1.00 32.14 ? 385 PRO A CD  1 
ATOM   2608 N  N   . ASP A 1 392 ? -31.245 -9.390  -42.399 1.00 26.86 ? 386 ASP A N   1 
ATOM   2609 C  CA  . ASP A 1 392 ? -30.101 -10.122 -42.927 1.00 26.30 ? 386 ASP A CA  1 
ATOM   2610 C  C   . ASP A 1 392 ? -29.597 -11.220 -41.989 1.00 26.35 ? 386 ASP A C   1 
ATOM   2611 O  O   . ASP A 1 392 ? -28.508 -11.757 -42.217 1.00 24.86 ? 386 ASP A O   1 
ATOM   2612 C  CB  . ASP A 1 392 ? -28.964 -9.156  -43.245 1.00 24.50 ? 386 ASP A CB  1 
ATOM   2613 C  CG  . ASP A 1 392 ? -28.317 -8.588  -41.999 1.00 34.30 ? 386 ASP A CG  1 
ATOM   2614 O  OD1 . ASP A 1 392 ? -28.952 -8.607  -40.914 1.00 31.32 ? 386 ASP A OD1 1 
ATOM   2615 O  OD2 . ASP A 1 392 ? -27.162 -8.130  -42.114 1.00 38.49 ? 386 ASP A OD2 1 
ATOM   2616 N  N   . GLY A 1 393 ? -30.344 -11.552 -40.934 1.00 22.90 ? 387 GLY A N   1 
ATOM   2617 C  CA  . GLY A 1 393 ? -29.982 -12.637 -40.048 1.00 24.20 ? 387 GLY A CA  1 
ATOM   2618 C  C   . GLY A 1 393 ? -29.212 -12.249 -38.795 1.00 26.29 ? 387 GLY A C   1 
ATOM   2619 O  O   . GLY A 1 393 ? -29.014 -13.111 -37.930 1.00 23.73 ? 387 GLY A O   1 
ATOM   2620 N  N   . THR A 1 394 ? -28.781 -10.991 -38.663 1.00 24.13 ? 388 THR A N   1 
ATOM   2621 C  CA  . THR A 1 394 ? -27.972 -10.559 -37.530 1.00 28.88 ? 388 THR A CA  1 
ATOM   2622 C  C   . THR A 1 394 ? -28.839 -9.987  -36.410 1.00 24.36 ? 388 THR A C   1 
ATOM   2623 O  O   . THR A 1 394 ? -30.067 -9.971  -36.483 1.00 24.23 ? 388 THR A O   1 
ATOM   2624 C  CB  . THR A 1 394 ? -26.940 -9.522  -37.965 1.00 27.73 ? 388 THR A CB  1 
ATOM   2625 O  OG1 . THR A 1 394 ? -27.621 -8.349  -38.426 1.00 29.05 ? 388 THR A OG1 1 
ATOM   2626 C  CG2 . THR A 1 394 ? -26.036 -10.073 -39.050 1.00 32.25 ? 388 THR A CG2 1 
ATOM   2627 N  N   . PHE A 1 395 ? -28.187 -9.503  -35.351 1.00 31.93 ? 389 PHE A N   1 
ATOM   2628 C  CA  . PHE A 1 395 ? -28.945 -9.020  -34.200 1.00 32.36 ? 389 PHE A CA  1 
ATOM   2629 C  C   . PHE A 1 395 ? -28.542 -7.598  -33.776 1.00 32.36 ? 389 PHE A C   1 
ATOM   2630 O  O   . PHE A 1 395 ? -29.331 -6.669  -33.969 1.00 41.78 ? 389 PHE A O   1 
ATOM   2631 C  CB  . PHE A 1 395 ? -28.830 -10.052 -33.071 1.00 23.81 ? 389 PHE A CB  1 
ATOM   2632 C  CG  . PHE A 1 395 ? -29.594 -11.344 -33.363 1.00 25.79 ? 389 PHE A CG  1 
ATOM   2633 C  CD1 . PHE A 1 395 ? -30.964 -11.427 -33.139 1.00 20.73 ? 389 PHE A CD1 1 
ATOM   2634 C  CD2 . PHE A 1 395 ? -28.942 -12.462 -33.898 1.00 21.05 ? 389 PHE A CD2 1 
ATOM   2635 C  CE1 . PHE A 1 395 ? -31.671 -12.603 -33.429 1.00 21.42 ? 389 PHE A CE1 1 
ATOM   2636 C  CE2 . PHE A 1 395 ? -29.639 -13.632 -34.201 1.00 19.51 ? 389 PHE A CE2 1 
ATOM   2637 C  CZ  . PHE A 1 395 ? -31.001 -13.708 -33.969 1.00 18.21 ? 389 PHE A CZ  1 
ATOM   2638 N  N   . GLU A 1 396 ? -27.344 -7.384  -33.228 1.00 37.61 ? 390 GLU A N   1 
ATOM   2639 C  CA  . GLU A 1 396 ? -26.969 -6.060  -32.706 1.00 42.27 ? 390 GLU A CA  1 
ATOM   2640 C  C   . GLU A 1 396 ? -25.519 -6.079  -32.242 1.00 42.76 ? 390 GLU A C   1 
ATOM   2641 O  O   . GLU A 1 396 ? -24.937 -7.144  -32.014 1.00 46.42 ? 390 GLU A O   1 
ATOM   2642 C  CB  . GLU A 1 396 ? -27.851 -5.633  -31.528 1.00 38.42 ? 390 GLU A CB  1 
ATOM   2643 C  CG  . GLU A 1 396 ? -27.729 -6.587  -30.319 1.00 39.31 ? 390 GLU A CG  1 
ATOM   2644 C  CD  . GLU A 1 396 ? -28.360 -6.059  -29.011 1.00 47.10 ? 390 GLU A CD  1 
ATOM   2645 O  OE1 . GLU A 1 396 ? -29.324 -5.255  -29.087 1.00 46.89 ? 390 GLU A OE1 1 
ATOM   2646 O  OE2 . GLU A 1 396 ? -27.924 -6.498  -27.906 1.00 40.93 ? 390 GLU A OE2 1 
ATOM   2647 N  N   . ARG A 1 397 ? -24.945 -4.890  -32.105 1.00 33.34 ? 391 ARG A N   1 
ATOM   2648 C  CA  . ARG A 1 397 ? -23.704 -4.686  -31.367 1.00 38.54 ? 391 ARG A CA  1 
ATOM   2649 C  C   . ARG A 1 397 ? -24.036 -3.903  -30.103 1.00 41.45 ? 391 ARG A C   1 
ATOM   2650 O  O   . ARG A 1 397 ? -24.806 -2.934  -30.148 1.00 43.40 ? 391 ARG A O   1 
ATOM   2651 C  CB  . ARG A 1 397 ? -22.667 -3.924  -32.200 1.00 39.14 ? 391 ARG A CB  1 
ATOM   2652 C  CG  . ARG A 1 397 ? -21.950 -4.729  -33.288 1.00 36.06 ? 391 ARG A CG  1 
ATOM   2653 C  CD  . ARG A 1 397 ? -21.157 -3.751  -34.161 1.00 38.23 ? 391 ARG A CD  1 
ATOM   2654 N  NE  . ARG A 1 397 ? -20.500 -4.367  -35.311 1.00 36.28 ? 391 ARG A NE  1 
ATOM   2655 C  CZ  . ARG A 1 397 ? -21.130 -4.854  -36.373 1.00 36.03 ? 391 ARG A CZ  1 
ATOM   2656 N  NH1 . ARG A 1 397 ? -22.452 -4.899  -36.435 1.00 34.60 ? 391 ARG A NH1 1 
ATOM   2657 N  NH2 . ARG A 1 397 ? -20.415 -5.319  -37.398 1.00 32.08 ? 391 ARG A NH2 1 
ATOM   2658 N  N   . SER A 1 398 ? -23.475 -4.332  -28.974 1.00 46.26 ? 392 SER A N   1 
ATOM   2659 C  CA  . SER A 1 398 ? -23.708 -3.644  -27.708 1.00 44.68 ? 392 SER A CA  1 
ATOM   2660 C  C   . SER A 1 398 ? -22.428 -3.649  -26.884 1.00 38.10 ? 392 SER A C   1 
ATOM   2661 O  O   . SER A 1 398 ? -21.509 -2.866  -27.142 1.00 38.31 ? 392 SER A O   1 
ATOM   2662 C  CB  . SER A 1 398 ? -24.859 -4.299  -26.937 1.00 41.40 ? 392 SER A CB  1 
ATOM   2663 O  OG  . SER A 1 398 ? -25.182 -3.574  -25.760 1.00 41.61 ? 392 SER A OG  1 
ATOM   2664 N  N   . TRP A 1 399 ? -22.344 -4.552  -25.910 1.00 36.15 ? 393 TRP A N   1 
ATOM   2665 C  CA  . TRP A 1 399 ? -21.158 -4.620  -25.063 1.00 38.03 ? 393 TRP A CA  1 
ATOM   2666 C  C   . TRP A 1 399 ? -19.949 -5.209  -25.790 1.00 38.72 ? 393 TRP A C   1 
ATOM   2667 O  O   . TRP A 1 399 ? -18.831 -5.128  -25.262 1.00 37.93 ? 393 TRP A O   1 
ATOM   2668 C  CB  . TRP A 1 399 ? -21.476 -5.426  -23.796 1.00 37.19 ? 393 TRP A CB  1 
ATOM   2669 C  CG  . TRP A 1 399 ? -22.516 -4.764  -22.919 1.00 40.16 ? 393 TRP A CG  1 
ATOM   2670 C  CD1 . TRP A 1 399 ? -23.704 -5.304  -22.516 1.00 39.54 ? 393 TRP A CD1 1 
ATOM   2671 C  CD2 . TRP A 1 399 ? -22.450 -3.448  -22.326 1.00 41.00 ? 393 TRP A CD2 1 
ATOM   2672 N  NE1 . TRP A 1 399 ? -24.382 -4.415  -21.710 1.00 41.98 ? 393 TRP A NE1 1 
ATOM   2673 C  CE2 . TRP A 1 399 ? -23.641 -3.267  -21.580 1.00 41.57 ? 393 TRP A CE2 1 
ATOM   2674 C  CE3 . TRP A 1 399 ? -21.504 -2.409  -22.355 1.00 40.44 ? 393 TRP A CE3 1 
ATOM   2675 C  CZ2 . TRP A 1 399 ? -23.914 -2.084  -20.864 1.00 34.31 ? 393 TRP A CZ2 1 
ATOM   2676 C  CZ3 . TRP A 1 399 ? -21.776 -1.233  -21.635 1.00 40.52 ? 393 TRP A CZ3 1 
ATOM   2677 C  CH2 . TRP A 1 399 ? -22.974 -1.086  -20.903 1.00 35.82 ? 393 TRP A CH2 1 
ATOM   2678 N  N   . SER A 1 400 ? -20.144 -5.803  -26.968 1.00 34.05 ? 394 SER A N   1 
ATOM   2679 C  CA  . SER A 1 400 ? -19.055 -6.197  -27.846 1.00 32.99 ? 394 SER A CA  1 
ATOM   2680 C  C   . SER A 1 400 ? -19.165 -5.409  -29.146 1.00 32.65 ? 394 SER A C   1 
ATOM   2681 O  O   . SER A 1 400 ? -20.253 -4.966  -29.531 1.00 33.76 ? 394 SER A O   1 
ATOM   2682 C  CB  . SER A 1 400 ? -19.084 -7.707  -28.137 1.00 32.21 ? 394 SER A CB  1 
ATOM   2683 O  OG  . SER A 1 400 ? -18.360 -8.428  -27.156 1.00 36.70 ? 394 SER A OG  1 
ATOM   2684 N  N   . ARG A 1 401 ? -18.028 -5.231  -29.818 1.00 31.14 ? 395 ARG A N   1 
ATOM   2685 C  CA  . ARG A 1 401 ? -17.958 -4.472  -31.063 1.00 36.65 ? 395 ARG A CA  1 
ATOM   2686 C  C   . ARG A 1 401 ? -18.026 -5.348  -32.312 1.00 33.69 ? 395 ARG A C   1 
ATOM   2687 O  O   . ARG A 1 401 ? -17.972 -4.819  -33.429 1.00 32.63 ? 395 ARG A O   1 
ATOM   2688 C  CB  . ARG A 1 401 ? -16.677 -3.629  -31.100 1.00 26.35 ? 395 ARG A CB  1 
ATOM   2689 C  CG  . ARG A 1 401 ? -16.720 -2.414  -30.167 1.00 35.96 ? 395 ARG A CG  1 
ATOM   2690 C  CD  . ARG A 1 401 ? -18.134 -2.145  -29.626 1.00 34.63 ? 395 ARG A CD  1 
ATOM   2691 N  NE  . ARG A 1 401 ? -19.062 -1.734  -30.676 1.00 45.30 ? 395 ARG A NE  1 
ATOM   2692 C  CZ  . ARG A 1 401 ? -20.286 -1.258  -30.471 1.00 46.75 ? 395 ARG A CZ  1 
ATOM   2693 N  NH1 . ARG A 1 401 ? -20.768 -1.070  -29.243 1.00 36.76 ? 395 ARG A NH1 1 
ATOM   2694 N  NH2 . ARG A 1 401 ? -21.046 -0.960  -31.525 1.00 38.04 ? 395 ARG A NH2 1 
ATOM   2695 N  N   . ASN A 1 402 ? -18.123 -6.664  -32.170 1.00 30.69 ? 396 ASN A N   1 
ATOM   2696 C  CA  . ASN A 1 402 ? -18.299 -7.480  -33.360 1.00 29.52 ? 396 ASN A CA  1 
ATOM   2697 C  C   . ASN A 1 402 ? -19.744 -7.934  -33.480 1.00 25.48 ? 396 ASN A C   1 
ATOM   2698 O  O   . ASN A 1 402 ? -20.502 -7.970  -32.505 1.00 27.68 ? 396 ASN A O   1 
ATOM   2699 C  CB  . ASN A 1 402 ? -17.361 -8.692  -33.351 1.00 29.16 ? 396 ASN A CB  1 
ATOM   2700 C  CG  . ASN A 1 402 ? -17.336 -9.383  -32.023 1.00 27.45 ? 396 ASN A CG  1 
ATOM   2701 O  OD1 . ASN A 1 402 ? -18.375 -9.787  -31.501 1.00 26.74 ? 396 ASN A OD1 1 
ATOM   2702 N  ND2 . ASN A 1 402 ? -16.149 -9.498  -31.445 1.00 27.10 ? 396 ASN A ND2 1 
ATOM   2703 N  N   . ALA A 1 403 ? -20.111 -8.292  -34.706 1.00 28.31 ? 397 ALA A N   1 
ATOM   2704 C  CA  . ALA A 1 403 ? -21.415 -8.886  -34.947 1.00 25.07 ? 397 ALA A CA  1 
ATOM   2705 C  C   . ALA A 1 403 ? -21.510 -10.294 -34.376 1.00 22.72 ? 397 ALA A C   1 
ATOM   2706 O  O   . ALA A 1 403 ? -22.591 -10.708 -33.943 1.00 24.42 ? 397 ALA A O   1 
ATOM   2707 C  CB  . ALA A 1 403 ? -21.701 -8.893  -36.443 1.00 26.20 ? 397 ALA A CB  1 
ATOM   2708 N  N   . THR A 1 404 ? -20.402 -11.040 -34.336 1.00 20.40 ? 398 THR A N   1 
ATOM   2709 C  CA  . THR A 1 404 ? -20.519 -12.452 -33.953 1.00 21.00 ? 398 THR A CA  1 
ATOM   2710 C  C   . THR A 1 404 ? -20.934 -12.651 -32.494 1.00 21.46 ? 398 THR A C   1 
ATOM   2711 O  O   . THR A 1 404 ? -21.458 -13.722 -32.158 1.00 19.17 ? 398 THR A O   1 
ATOM   2712 C  CB  . THR A 1 404 ? -19.207 -13.194 -34.226 1.00 19.04 ? 398 THR A CB  1 
ATOM   2713 O  OG1 . THR A 1 404 ? -18.166 -12.642 -33.420 1.00 20.21 ? 398 THR A OG1 1 
ATOM   2714 C  CG2 . THR A 1 404 ? -18.808 -13.059 -35.700 1.00 15.86 ? 398 THR A CG2 1 
ATOM   2715 N  N   . ASN A 1 405 ? -20.754 -11.648 -31.624 1.00 21.02 ? 399 ASN A N   1 
ATOM   2716 C  CA  . ASN A 1 405 ? -21.074 -11.854 -30.211 1.00 20.58 ? 399 ASN A CA  1 
ATOM   2717 C  C   . ASN A 1 405 ? -22.567 -12.075 -30.008 1.00 18.52 ? 399 ASN A C   1 
ATOM   2718 O  O   . ASN A 1 405 ? -22.981 -13.043 -29.361 1.00 22.67 ? 399 ASN A O   1 
ATOM   2719 C  CB  . ASN A 1 405 ? -20.606 -10.672 -29.355 1.00 18.71 ? 399 ASN A CB  1 
ATOM   2720 C  CG  . ASN A 1 405 ? -20.952 -10.870 -27.863 1.00 26.85 ? 399 ASN A CG  1 
ATOM   2721 O  OD1 . ASN A 1 405 ? -20.233 -11.539 -27.133 1.00 27.62 ? 399 ASN A OD1 1 
ATOM   2722 N  ND2 . ASN A 1 405 ? -22.080 -10.330 -27.439 1.00 28.30 ? 399 ASN A ND2 1 
ATOM   2723 N  N   . ALA A 1 406 ? -23.391 -11.169 -30.526 1.00 21.15 ? 400 ALA A N   1 
ATOM   2724 C  CA  . ALA A 1 406 ? -24.835 -11.336 -30.403 1.00 24.42 ? 400 ALA A CA  1 
ATOM   2725 C  C   . ALA A 1 406 ? -25.307 -12.591 -31.126 1.00 20.11 ? 400 ALA A C   1 
ATOM   2726 O  O   . ALA A 1 406 ? -26.194 -13.305 -30.639 1.00 23.59 ? 400 ALA A O   1 
ATOM   2727 C  CB  . ALA A 1 406 ? -25.557 -10.097 -30.934 1.00 27.74 ? 400 ALA A CB  1 
ATOM   2728 N  N   . VAL A 1 407 ? -24.695 -12.917 -32.261 1.00 19.42 ? 401 VAL A N   1 
ATOM   2729 C  CA  . VAL A 1 407 ? -25.112 -14.131 -32.953 1.00 19.76 ? 401 VAL A CA  1 
ATOM   2730 C  C   . VAL A 1 407 ? -24.901 -15.336 -32.042 1.00 19.47 ? 401 VAL A C   1 
ATOM   2731 O  O   . VAL A 1 407 ? -25.798 -16.165 -31.876 1.00 19.39 ? 401 VAL A O   1 
ATOM   2732 C  CB  . VAL A 1 407 ? -24.383 -14.272 -34.302 1.00 17.32 ? 401 VAL A CB  1 
ATOM   2733 C  CG1 . VAL A 1 407 ? -24.662 -15.630 -34.934 1.00 18.23 ? 401 VAL A CG1 1 
ATOM   2734 C  CG2 . VAL A 1 407 ? -24.808 -13.151 -35.235 1.00 21.37 ? 401 VAL A CG2 1 
ATOM   2735 N  N   . PHE A 1 408 ? -23.742 -15.404 -31.370 1.00 20.85 ? 402 PHE A N   1 
ATOM   2736 C  CA  . PHE A 1 408 ? -23.442 -16.565 -30.528 1.00 18.06 ? 402 PHE A CA  1 
ATOM   2737 C  C   . PHE A 1 408 ? -24.436 -16.674 -29.372 1.00 21.33 ? 402 PHE A C   1 
ATOM   2738 O  O   . PHE A 1 408 ? -25.041 -17.733 -29.174 1.00 23.30 ? 402 PHE A O   1 
ATOM   2739 C  CB  . PHE A 1 408 ? -21.962 -16.503 -30.096 1.00 23.11 ? 402 PHE A CB  1 
ATOM   2740 C  CG  . PHE A 1 408 ? -21.684 -16.608 -28.601 1.00 22.34 ? 402 PHE A CG  1 
ATOM   2741 C  CD1 . PHE A 1 408 ? -21.945 -17.769 -27.895 1.00 19.56 ? 402 PHE A CD1 1 
ATOM   2742 C  CD2 . PHE A 1 408 ? -21.046 -15.568 -27.944 1.00 25.27 ? 402 PHE A CD2 1 
ATOM   2743 C  CE1 . PHE A 1 408 ? -21.642 -17.858 -26.554 1.00 25.70 ? 402 PHE A CE1 1 
ATOM   2744 C  CE2 . PHE A 1 408 ? -20.733 -15.656 -26.589 1.00 23.50 ? 402 PHE A CE2 1 
ATOM   2745 C  CZ  . PHE A 1 408 ? -21.037 -16.788 -25.896 1.00 23.72 ? 402 PHE A CZ  1 
ATOM   2746 N  N   . ARG A 1 409 ? -24.692 -15.568 -28.660 1.00 18.62 ? 403 ARG A N   1 
ATOM   2747 C  CA  . ARG A 1 409 ? -25.751 -15.562 -27.645 1.00 22.76 ? 403 ARG A CA  1 
ATOM   2748 C  C   . ARG A 1 409 ? -27.060 -16.062 -28.230 1.00 21.49 ? 403 ARG A C   1 
ATOM   2749 O  O   . ARG A 1 409 ? -27.679 -16.993 -27.699 1.00 20.87 ? 403 ARG A O   1 
ATOM   2750 C  CB  . ARG A 1 409 ? -25.962 -14.148 -27.072 1.00 21.59 ? 403 ARG A CB  1 
ATOM   2751 C  CG  . ARG A 1 409 ? -24.824 -13.647 -26.222 1.00 22.59 ? 403 ARG A CG  1 
ATOM   2752 C  CD  . ARG A 1 409 ? -24.390 -14.740 -25.243 1.00 30.96 ? 403 ARG A CD  1 
ATOM   2753 N  NE  . ARG A 1 409 ? -23.966 -14.187 -23.964 1.00 35.66 ? 403 ARG A NE  1 
ATOM   2754 C  CZ  . ARG A 1 409 ? -23.670 -14.916 -22.899 1.00 35.88 ? 403 ARG A CZ  1 
ATOM   2755 N  NH1 . ARG A 1 409 ? -23.739 -16.236 -22.927 1.00 34.27 ? 403 ARG A NH1 1 
ATOM   2756 N  NH2 . ARG A 1 409 ? -23.320 -14.302 -21.771 1.00 40.58 ? 403 ARG A NH2 1 
ATOM   2757 N  N   . ALA A 1 410 ? -27.508 -15.425 -29.320 1.00 21.91 ? 404 ALA A N   1 
ATOM   2758 C  CA  . ALA A 1 410 ? -28.788 -15.789 -29.916 1.00 19.51 ? 404 ALA A CA  1 
ATOM   2759 C  C   . ALA A 1 410 ? -28.830 -17.269 -30.263 1.00 19.34 ? 404 ALA A C   1 
ATOM   2760 O  O   . ALA A 1 410 ? -29.795 -17.963 -29.933 1.00 22.05 ? 404 ALA A O   1 
ATOM   2761 C  CB  . ALA A 1 410 ? -29.073 -14.925 -31.154 1.00 19.22 ? 404 ALA A CB  1 
ATOM   2762 N  N   . VAL A 1 411 ? -27.780 -17.786 -30.891 1.00 19.18 ? 405 VAL A N   1 
ATOM   2763 C  CA  . VAL A 1 411 ? -27.851 -19.167 -31.358 1.00 17.20 ? 405 VAL A CA  1 
ATOM   2764 C  C   . VAL A 1 411 ? -27.933 -20.145 -30.184 1.00 22.32 ? 405 VAL A C   1 
ATOM   2765 O  O   . VAL A 1 411 ? -28.635 -21.163 -30.261 1.00 24.44 ? 405 VAL A O   1 
ATOM   2766 C  CB  . VAL A 1 411 ? -26.667 -19.459 -32.300 1.00 17.10 ? 405 VAL A CB  1 
ATOM   2767 C  CG1 . VAL A 1 411 ? -26.542 -20.944 -32.590 1.00 17.01 ? 405 VAL A CG1 1 
ATOM   2768 C  CG2 . VAL A 1 411 ? -26.854 -18.683 -33.621 1.00 17.74 ? 405 VAL A CG2 1 
ATOM   2769 N  N   . LEU A 1 412 ? -27.223 -19.871 -29.080 1.00 22.56 ? 406 LEU A N   1 
ATOM   2770 C  CA  . LEU A 1 412 ? -27.295 -20.784 -27.934 1.00 22.93 ? 406 LEU A CA  1 
ATOM   2771 C  C   . LEU A 1 412 ? -28.685 -20.769 -27.307 1.00 20.03 ? 406 LEU A C   1 
ATOM   2772 O  O   . LEU A 1 412 ? -29.239 -21.824 -26.982 1.00 23.71 ? 406 LEU A O   1 
ATOM   2773 C  CB  . LEU A 1 412 ? -26.232 -20.431 -26.883 1.00 22.05 ? 406 LEU A CB  1 
ATOM   2774 C  CG  . LEU A 1 412 ? -24.771 -20.846 -27.121 1.00 27.21 ? 406 LEU A CG  1 
ATOM   2775 C  CD1 . LEU A 1 412 ? -23.915 -20.676 -25.868 1.00 27.96 ? 406 LEU A CD1 1 
ATOM   2776 C  CD2 . LEU A 1 412 ? -24.638 -22.268 -27.636 1.00 32.49 ? 406 LEU A CD2 1 
ATOM   2777 N  N   . ALA A 1 413 ? -29.272 -19.586 -27.133 1.00 21.14 ? 407 ALA A N   1 
ATOM   2778 C  CA  . ALA A 1 413 ? -30.659 -19.526 -26.680 1.00 24.33 ? 407 ALA A CA  1 
ATOM   2779 C  C   . ALA A 1 413 ? -31.600 -20.251 -27.649 1.00 30.43 ? 407 ALA A C   1 
ATOM   2780 O  O   . ALA A 1 413 ? -32.529 -20.949 -27.221 1.00 33.28 ? 407 ALA A O   1 
ATOM   2781 C  CB  . ALA A 1 413 ? -31.080 -18.074 -26.504 1.00 21.41 ? 407 ALA A CB  1 
ATOM   2782 N  N   . LEU A 1 414 ? -31.367 -20.116 -28.958 1.00 21.74 ? 408 LEU A N   1 
ATOM   2783 C  CA  . LEU A 1 414 ? -32.314 -20.657 -29.927 1.00 27.25 ? 408 LEU A CA  1 
ATOM   2784 C  C   . LEU A 1 414 ? -32.251 -22.176 -30.000 1.00 31.50 ? 408 LEU A C   1 
ATOM   2785 O  O   . LEU A 1 414 ? -33.251 -22.822 -30.334 1.00 31.60 ? 408 LEU A O   1 
ATOM   2786 C  CB  . LEU A 1 414 ? -32.049 -20.068 -31.310 1.00 21.79 ? 408 LEU A CB  1 
ATOM   2787 C  CG  . LEU A 1 414 ? -32.492 -18.628 -31.457 1.00 23.50 ? 408 LEU A CG  1 
ATOM   2788 C  CD1 . LEU A 1 414 ? -31.890 -18.029 -32.734 1.00 27.16 ? 408 LEU A CD1 1 
ATOM   2789 C  CD2 . LEU A 1 414 ? -33.991 -18.637 -31.504 1.00 23.38 ? 408 LEU A CD2 1 
ATOM   2790 N  N   . THR A 1 415 ? -31.085 -22.755 -29.725 1.00 30.90 ? 409 THR A N   1 
ATOM   2791 C  CA  . THR A 1 415 ? -30.861 -24.181 -29.860 1.00 31.60 ? 409 THR A CA  1 
ATOM   2792 C  C   . THR A 1 415 ? -30.748 -24.914 -28.533 1.00 36.86 ? 409 THR A C   1 
ATOM   2793 O  O   . THR A 1 415 ? -30.694 -26.149 -28.539 1.00 44.10 ? 409 THR A O   1 
ATOM   2794 C  CB  . THR A 1 415 ? -29.577 -24.444 -30.659 1.00 33.67 ? 409 THR A CB  1 
ATOM   2795 O  OG1 . THR A 1 415 ? -28.464 -23.915 -29.931 1.00 32.82 ? 409 THR A OG1 1 
ATOM   2796 C  CG2 . THR A 1 415 ? -29.642 -23.804 -32.049 1.00 23.54 ? 409 THR A CG2 1 
ATOM   2797 N  N   . GLY A 1 416 ? -30.695 -24.208 -27.407 1.00 30.74 ? 410 GLY A N   1 
ATOM   2798 C  CA  . GLY A 1 416 ? -30.457 -24.869 -26.139 1.00 35.23 ? 410 GLY A CA  1 
ATOM   2799 C  C   . GLY A 1 416 ? -31.726 -25.089 -25.349 1.00 39.08 ? 410 GLY A C   1 
ATOM   2800 O  O   . GLY A 1 416 ? -31.857 -26.058 -24.601 1.00 41.22 ? 410 GLY A O   1 
ATOM   2801 N  N   . VAL A 1 417 ? -32.674 -24.174 -25.497 1.00 43.23 ? 411 VAL A N   1 
ATOM   2802 C  CA  . VAL A 1 417 ? -33.999 -24.362 -24.925 1.00 46.57 ? 411 VAL A CA  1 
ATOM   2803 C  C   . VAL A 1 417 ? -34.721 -25.359 -25.822 1.00 44.47 ? 411 VAL A C   1 
ATOM   2804 O  O   . VAL A 1 417 ? -35.031 -25.049 -26.976 1.00 43.91 ? 411 VAL A O   1 
ATOM   2805 C  CB  . VAL A 1 417 ? -34.763 -23.038 -24.831 1.00 40.87 ? 411 VAL A CB  1 
ATOM   2806 C  CG1 . VAL A 1 417 ? -36.188 -23.276 -24.330 1.00 44.48 ? 411 VAL A CG1 1 
ATOM   2807 C  CG2 . VAL A 1 417 ? -34.005 -22.065 -23.950 1.00 40.02 ? 411 VAL A CG2 1 
ATOM   2808 N  N   . ALA A 1 418 ? -34.955 -26.567 -25.311 1.00 49.72 ? 412 ALA A N   1 
ATOM   2809 C  CA  . ALA A 1 418 ? -35.614 -27.589 -26.113 1.00 49.65 ? 412 ALA A CA  1 
ATOM   2810 C  C   . ALA A 1 418 ? -36.989 -27.099 -26.543 1.00 49.38 ? 412 ALA A C   1 
ATOM   2811 O  O   . ALA A 1 418 ? -37.665 -26.360 -25.817 1.00 50.57 ? 412 ALA A O   1 
ATOM   2812 C  CB  . ALA A 1 418 ? -35.733 -28.901 -25.334 1.00 50.34 ? 412 ALA A CB  1 
ATOM   2813 N  N   . ALA A 1 419 ? -37.399 -27.501 -27.740 1.00 43.31 ? 413 ALA A N   1 
ATOM   2814 C  CA  . ALA A 1 419 ? -38.633 -26.986 -28.301 1.00 39.43 ? 413 ALA A CA  1 
ATOM   2815 C  C   . ALA A 1 419 ? -39.118 -27.965 -29.348 1.00 42.64 ? 413 ALA A C   1 
ATOM   2816 O  O   . ALA A 1 419 ? -38.325 -28.685 -29.962 1.00 44.67 ? 413 ALA A O   1 
ATOM   2817 C  CB  . ALA A 1 419 ? -38.438 -25.596 -28.915 1.00 35.39 ? 413 ALA A CB  1 
ATOM   2818 N  N   . HIS A 1 420 ? -40.427 -27.986 -29.546 1.00 42.58 ? 414 HIS A N   1 
ATOM   2819 C  CA  . HIS A 1 420 ? -41.014 -28.937 -30.471 1.00 44.43 ? 414 HIS A CA  1 
ATOM   2820 C  C   . HIS A 1 420 ? -42.218 -28.287 -31.120 1.00 41.12 ? 414 HIS A C   1 
ATOM   2821 O  O   . HIS A 1 420 ? -42.825 -27.374 -30.551 1.00 44.42 ? 414 HIS A O   1 
ATOM   2822 C  CB  . HIS A 1 420 ? -41.417 -30.237 -29.764 1.00 38.67 ? 414 HIS A CB  1 
ATOM   2823 C  CG  . HIS A 1 420 ? -40.356 -30.781 -28.856 1.00 44.57 ? 414 HIS A CG  1 
ATOM   2824 N  ND1 . HIS A 1 420 ? -40.225 -30.377 -27.543 1.00 43.65 ? 414 HIS A ND1 1 
ATOM   2825 C  CD2 . HIS A 1 420 ? -39.378 -31.695 -29.069 1.00 41.65 ? 414 HIS A CD2 1 
ATOM   2826 C  CE1 . HIS A 1 420 ? -39.211 -31.023 -26.987 1.00 42.78 ? 414 HIS A CE1 1 
ATOM   2827 N  NE2 . HIS A 1 420 ? -38.683 -31.829 -27.892 1.00 40.92 ? 414 HIS A NE2 1 
ATOM   2828 N  N   . GLY A 1 421 ? -42.550 -28.766 -32.317 1.00 39.54 ? 415 GLY A N   1 
ATOM   2829 C  CA  . GLY A 1 421 ? -43.692 -28.257 -33.052 1.00 38.89 ? 415 GLY A CA  1 
ATOM   2830 C  C   . GLY A 1 421 ? -43.374 -27.011 -33.852 1.00 43.20 ? 415 GLY A C   1 
ATOM   2831 O  O   . GLY A 1 421 ? -42.270 -26.887 -34.400 1.00 40.87 ? 415 GLY A O   1 
ATOM   2832 N  N   . GLU A 1 422 ? -44.332 -26.077 -33.922 1.00 37.88 ? 416 GLU A N   1 
ATOM   2833 C  CA  . GLU A 1 422 ? -44.143 -24.880 -34.737 1.00 42.52 ? 416 GLU A CA  1 
ATOM   2834 C  C   . GLU A 1 422 ? -43.073 -23.963 -34.155 1.00 41.06 ? 416 GLU A C   1 
ATOM   2835 O  O   . GLU A 1 422 ? -42.344 -23.303 -34.911 1.00 35.95 ? 416 GLU A O   1 
ATOM   2836 C  CB  . GLU A 1 422 ? -45.463 -24.117 -34.887 1.00 45.30 ? 416 GLU A CB  1 
ATOM   2837 C  CG  . GLU A 1 422 ? -45.308 -22.718 -35.506 1.00 50.99 ? 416 GLU A CG  1 
ATOM   2838 C  CD  . GLU A 1 422 ? -46.569 -21.844 -35.385 1.00 62.20 ? 416 GLU A CD  1 
ATOM   2839 O  OE1 . GLU A 1 422 ? -47.109 -21.694 -34.257 1.00 60.07 ? 416 GLU A OE1 1 
ATOM   2840 O  OE2 . GLU A 1 422 ? -47.010 -21.293 -36.421 1.00 54.71 ? 416 GLU A OE2 1 
ATOM   2841 N  N   . GLU A 1 423 ? -42.961 -23.906 -32.824 1.00 36.75 ? 417 GLU A N   1 
ATOM   2842 C  CA  . GLU A 1 423 ? -41.932 -23.073 -32.216 1.00 37.35 ? 417 GLU A CA  1 
ATOM   2843 C  C   . GLU A 1 423 ? -40.545 -23.673 -32.427 1.00 33.83 ? 417 GLU A C   1 
ATOM   2844 O  O   . GLU A 1 423 ? -39.567 -22.935 -32.557 1.00 30.14 ? 417 GLU A O   1 
ATOM   2845 C  CB  . GLU A 1 423 ? -42.223 -22.871 -30.730 1.00 35.88 ? 417 GLU A CB  1 
ATOM   2846 C  CG  . GLU A 1 423 ? -41.978 -21.454 -30.225 1.00 36.99 ? 417 GLU A CG  1 
ATOM   2847 C  CD  . GLU A 1 423 ? -42.342 -21.296 -28.747 1.00 41.65 ? 417 GLU A CD  1 
ATOM   2848 O  OE1 . GLU A 1 423 ? -42.983 -22.212 -28.183 1.00 42.31 ? 417 GLU A OE1 1 
ATOM   2849 O  OE2 . GLU A 1 423 ? -41.960 -20.271 -28.142 1.00 44.00 ? 417 GLU A OE2 1 
ATOM   2850 N  N   . ARG A 1 424 ? -40.441 -24.999 -32.498 1.00 32.09 ? 418 ARG A N   1 
ATOM   2851 C  CA  . ARG A 1 424 ? -39.186 -25.604 -32.928 1.00 34.66 ? 418 ARG A CA  1 
ATOM   2852 C  C   . ARG A 1 424 ? -38.818 -25.140 -34.345 1.00 33.21 ? 418 ARG A C   1 
ATOM   2853 O  O   . ARG A 1 424 ? -37.693 -24.695 -34.593 1.00 30.70 ? 418 ARG A O   1 
ATOM   2854 C  CB  . ARG A 1 424 ? -39.305 -27.129 -32.823 1.00 37.31 ? 418 ARG A CB  1 
ATOM   2855 C  CG  . ARG A 1 424 ? -38.446 -27.975 -33.773 1.00 46.98 ? 418 ARG A CG  1 
ATOM   2856 C  CD  . ARG A 1 424 ? -36.977 -27.989 -33.365 1.00 44.70 ? 418 ARG A CD  1 
ATOM   2857 N  NE  . ARG A 1 424 ? -36.457 -26.631 -33.218 1.00 51.68 ? 418 ARG A NE  1 
ATOM   2858 C  CZ  . ARG A 1 424 ? -35.273 -26.325 -32.703 1.00 46.58 ? 418 ARG A CZ  1 
ATOM   2859 N  NH1 . ARG A 1 424 ? -34.476 -27.257 -32.204 1.00 51.74 ? 418 ARG A NH1 1 
ATOM   2860 N  NH2 . ARG A 1 424 ? -34.875 -25.054 -32.707 1.00 34.28 ? 418 ARG A NH2 1 
ATOM   2861 N  N   . ARG A 1 425 ? -39.771 -25.192 -35.279 1.00 28.59 ? 419 ARG A N   1 
ATOM   2862 C  CA  . ARG A 1 425 ? -39.515 -24.733 -36.642 1.00 34.94 ? 419 ARG A CA  1 
ATOM   2863 C  C   . ARG A 1 425 ? -39.070 -23.282 -36.652 1.00 28.85 ? 419 ARG A C   1 
ATOM   2864 O  O   . ARG A 1 425 ? -38.106 -22.908 -37.330 1.00 27.19 ? 419 ARG A O   1 
ATOM   2865 C  CB  . ARG A 1 425 ? -40.778 -24.880 -37.490 1.00 40.96 ? 419 ARG A CB  1 
ATOM   2866 C  CG  . ARG A 1 425 ? -40.637 -25.632 -38.800 1.00 46.34 ? 419 ARG A CG  1 
ATOM   2867 C  CD  . ARG A 1 425 ? -42.008 -25.748 -39.455 1.00 44.20 ? 419 ARG A CD  1 
ATOM   2868 N  NE  . ARG A 1 425 ? -42.701 -26.921 -38.931 1.00 57.40 ? 419 ARG A NE  1 
ATOM   2869 C  CZ  . ARG A 1 425 ? -43.750 -26.875 -38.114 1.00 55.30 ? 419 ARG A CZ  1 
ATOM   2870 N  NH1 . ARG A 1 425 ? -44.291 -25.723 -37.740 1.00 57.23 ? 419 ARG A NH1 1 
ATOM   2871 N  NH2 . ARG A 1 425 ? -44.261 -28.012 -37.651 1.00 45.25 ? 419 ARG A NH2 1 
ATOM   2872 N  N   . SER A 1 426 ? -39.781 -22.450 -35.906 1.00 26.14 ? 420 SER A N   1 
ATOM   2873 C  CA  . SER A 1 426 ? -39.524 -21.020 -35.920 1.00 31.43 ? 420 SER A CA  1 
ATOM   2874 C  C   . SER A 1 426 ? -38.156 -20.683 -35.319 1.00 28.74 ? 420 SER A C   1 
ATOM   2875 O  O   . SER A 1 426 ? -37.435 -19.829 -35.847 1.00 28.87 ? 420 SER A O   1 
ATOM   2876 C  CB  . SER A 1 426 ? -40.660 -20.315 -35.186 1.00 22.49 ? 420 SER A CB  1 
ATOM   2877 O  OG  . SER A 1 426 ? -40.214 -19.084 -34.684 1.00 37.42 ? 420 SER A OG  1 
ATOM   2878 N  N   . ARG A 1 427 ? -37.763 -21.353 -34.234 1.00 25.46 ? 421 ARG A N   1 
ATOM   2879 C  CA  . ARG A 1 427 ? -36.426 -21.114 -33.692 1.00 25.43 ? 421 ARG A CA  1 
ATOM   2880 C  C   . ARG A 1 427 ? -35.339 -21.668 -34.612 1.00 27.49 ? 421 ARG A C   1 
ATOM   2881 O  O   . ARG A 1 427 ? -34.281 -21.046 -34.763 1.00 24.64 ? 421 ARG A O   1 
ATOM   2882 C  CB  . ARG A 1 427 ? -36.305 -21.720 -32.298 1.00 27.12 ? 421 ARG A CB  1 
ATOM   2883 C  CG  . ARG A 1 427 ? -37.196 -21.042 -31.257 1.00 22.74 ? 421 ARG A CG  1 
ATOM   2884 C  CD  . ARG A 1 427 ? -37.153 -21.779 -29.913 1.00 25.38 ? 421 ARG A CD  1 
ATOM   2885 N  NE  . ARG A 1 427 ? -38.163 -21.265 -28.992 1.00 26.41 ? 421 ARG A NE  1 
ATOM   2886 C  CZ  . ARG A 1 427 ? -38.294 -21.652 -27.731 1.00 30.33 ? 421 ARG A CZ  1 
ATOM   2887 N  NH1 . ARG A 1 427 ? -37.492 -22.561 -27.203 1.00 33.57 ? 421 ARG A NH1 1 
ATOM   2888 N  NH2 . ARG A 1 427 ? -39.256 -21.114 -26.982 1.00 28.53 ? 421 ARG A NH2 1 
ATOM   2889 N  N   . ALA A 1 428 ? -35.574 -22.841 -35.228 1.00 20.71 ? 422 ALA A N   1 
ATOM   2890 C  CA  . ALA A 1 428 ? -34.572 -23.418 -36.116 1.00 20.57 ? 422 ALA A CA  1 
ATOM   2891 C  C   . ALA A 1 428 ? -34.326 -22.519 -37.320 1.00 23.13 ? 422 ALA A C   1 
ATOM   2892 O  O   . ALA A 1 428 ? -33.184 -22.354 -37.759 1.00 19.46 ? 422 ALA A O   1 
ATOM   2893 C  CB  . ALA A 1 428 ? -35.001 -24.813 -36.579 1.00 24.82 ? 422 ALA A CB  1 
ATOM   2894 N  N   . ARG A 1 429 ? -35.382 -21.911 -37.861 1.00 22.94 ? 423 ARG A N   1 
ATOM   2895 C  CA  . ARG A 1 429 ? -35.187 -20.996 -38.973 1.00 20.16 ? 423 ARG A CA  1 
ATOM   2896 C  C   . ARG A 1 429 ? -34.398 -19.768 -38.533 1.00 22.55 ? 423 ARG A C   1 
ATOM   2897 O  O   . ARG A 1 429 ? -33.464 -19.339 -39.224 1.00 24.08 ? 423 ARG A O   1 
ATOM   2898 C  CB  . ARG A 1 429 ? -36.541 -20.617 -39.573 1.00 21.00 ? 423 ARG A CB  1 
ATOM   2899 C  CG  . ARG A 1 429 ? -37.111 -21.701 -40.519 1.00 28.34 ? 423 ARG A CG  1 
ATOM   2900 C  CD  . ARG A 1 429 ? -38.624 -21.533 -40.712 1.00 33.54 ? 423 ARG A CD  1 
ATOM   2901 N  NE  . ARG A 1 429 ? -39.262 -22.673 -41.367 1.00 39.29 ? 423 ARG A NE  1 
ATOM   2902 C  CZ  . ARG A 1 429 ? -40.353 -22.578 -42.124 1.00 41.60 ? 423 ARG A CZ  1 
ATOM   2903 N  NH1 . ARG A 1 429 ? -40.929 -21.411 -42.370 1.00 37.07 ? 423 ARG A NH1 1 
ATOM   2904 N  NH2 . ARG A 1 429 ? -40.879 -23.682 -42.649 1.00 45.99 ? 423 ARG A NH2 1 
ATOM   2905 N  N   . ALA A 1 430 ? -34.732 -19.195 -37.378 1.00 22.57 ? 424 ALA A N   1 
ATOM   2906 C  CA  . ALA A 1 430 ? -33.985 -18.033 -36.914 1.00 21.06 ? 424 ALA A CA  1 
ATOM   2907 C  C   . ALA A 1 430 ? -32.512 -18.381 -36.732 1.00 18.77 ? 424 ALA A C   1 
ATOM   2908 O  O   . ALA A 1 430 ? -31.626 -17.651 -37.181 1.00 16.49 ? 424 ALA A O   1 
ATOM   2909 C  CB  . ALA A 1 430 ? -34.595 -17.502 -35.614 1.00 23.88 ? 424 ALA A CB  1 
ATOM   2910 N  N   . ALA A 1 431 ? -32.235 -19.515 -36.091 1.00 21.16 ? 425 ALA A N   1 
ATOM   2911 C  CA  . ALA A 1 431 ? -30.852 -19.938 -35.889 1.00 20.69 ? 425 ALA A CA  1 
ATOM   2912 C  C   . ALA A 1 431 ? -30.134 -20.144 -37.222 1.00 20.70 ? 425 ALA A C   1 
ATOM   2913 O  O   . ALA A 1 431 ? -28.990 -19.700 -37.395 1.00 21.75 ? 425 ALA A O   1 
ATOM   2914 C  CB  . ALA A 1 431 ? -30.822 -21.218 -35.040 1.00 15.73 ? 425 ALA A CB  1 
ATOM   2915 N  N   . GLU A 1 432 ? -30.793 -20.813 -38.177 1.00 21.18 ? 426 GLU A N   1 
ATOM   2916 C  CA  . GLU A 1 432 ? -30.194 -21.048 -39.493 1.00 20.95 ? 426 GLU A CA  1 
ATOM   2917 C  C   . GLU A 1 432 ? -29.788 -19.743 -40.174 1.00 19.31 ? 426 GLU A C   1 
ATOM   2918 O  O   . GLU A 1 432 ? -28.722 -19.665 -40.801 1.00 18.12 ? 426 GLU A O   1 
ATOM   2919 C  CB  . GLU A 1 432 ? -31.183 -21.794 -40.386 1.00 22.49 ? 426 GLU A CB  1 
ATOM   2920 C  CG  . GLU A 1 432 ? -31.168 -23.318 -40.350 1.00 33.05 ? 426 GLU A CG  1 
ATOM   2921 C  CD  . GLU A 1 432 ? -32.443 -23.898 -41.005 1.00 40.50 ? 426 GLU A CD  1 
ATOM   2922 O  OE1 . GLU A 1 432 ? -32.687 -23.606 -42.208 1.00 44.90 ? 426 GLU A OE1 1 
ATOM   2923 O  OE2 . GLU A 1 432 ? -33.192 -24.653 -40.340 1.00 39.95 ? 426 GLU A OE2 1 
ATOM   2924 N  N   . ARG A 1 433 ? -30.642 -18.718 -40.111 1.00 18.30 ? 427 ARG A N   1 
ATOM   2925 C  CA  . ARG A 1 433 ? -30.280 -17.458 -40.760 1.00 19.32 ? 427 ARG A CA  1 
ATOM   2926 C  C   . ARG A 1 433 ? -29.098 -16.798 -40.069 1.00 19.94 ? 427 ARG A C   1 
ATOM   2927 O  O   . ARG A 1 433 ? -28.285 -16.146 -40.734 1.00 18.48 ? 427 ARG A O   1 
ATOM   2928 C  CB  . ARG A 1 433 ? -31.477 -16.506 -40.809 1.00 20.84 ? 427 ARG A CB  1 
ATOM   2929 C  CG  . ARG A 1 433 ? -32.669 -17.041 -41.625 1.00 20.66 ? 427 ARG A CG  1 
ATOM   2930 C  CD  . ARG A 1 433 ? -33.548 -15.900 -42.142 1.00 26.90 ? 427 ARG A CD  1 
ATOM   2931 N  NE  . ARG A 1 433 ? -34.168 -15.161 -41.050 1.00 28.87 ? 427 ARG A NE  1 
ATOM   2932 C  CZ  . ARG A 1 433 ? -34.114 -13.843 -40.901 1.00 30.12 ? 427 ARG A CZ  1 
ATOM   2933 N  NH1 . ARG A 1 433 ? -33.523 -13.063 -41.798 1.00 27.32 ? 427 ARG A NH1 1 
ATOM   2934 N  NH2 . ARG A 1 433 ? -34.682 -13.292 -39.835 1.00 25.07 ? 427 ARG A NH2 1 
ATOM   2935 N  N   . ALA A 1 434 ? -28.973 -16.965 -38.744 1.00 19.11 ? 428 ALA A N   1 
ATOM   2936 C  CA  . ALA A 1 434 ? -27.820 -16.406 -38.044 1.00 18.19 ? 428 ALA A CA  1 
ATOM   2937 C  C   . ALA A 1 434 ? -26.537 -17.108 -38.467 1.00 18.19 ? 428 ALA A C   1 
ATOM   2938 O  O   . ALA A 1 434 ? -25.503 -16.457 -38.667 1.00 18.29 ? 428 ALA A O   1 
ATOM   2939 C  CB  . ALA A 1 434 ? -28.023 -16.486 -36.524 1.00 19.65 ? 428 ALA A CB  1 
ATOM   2940 N  N   . LEU A 1 435 ? -26.583 -18.432 -38.635 1.00 16.18 ? 429 LEU A N   1 
ATOM   2941 C  CA  . LEU A 1 435 ? -25.378 -19.145 -39.053 1.00 18.42 ? 429 LEU A CA  1 
ATOM   2942 C  C   . LEU A 1 435 ? -25.071 -18.913 -40.531 1.00 17.96 ? 429 LEU A C   1 
ATOM   2943 O  O   . LEU A 1 435 ? -23.894 -18.867 -40.919 1.00 17.22 ? 429 LEU A O   1 
ATOM   2944 C  CB  . LEU A 1 435 ? -25.523 -20.643 -38.751 1.00 15.99 ? 429 LEU A CB  1 
ATOM   2945 C  CG  . LEU A 1 435 ? -25.690 -21.050 -37.270 1.00 17.75 ? 429 LEU A CG  1 
ATOM   2946 C  CD1 . LEU A 1 435 ? -25.669 -22.561 -37.153 1.00 18.69 ? 429 LEU A CD1 1 
ATOM   2947 C  CD2 . LEU A 1 435 ? -24.597 -20.447 -36.358 1.00 14.23 ? 429 LEU A CD2 1 
ATOM   2948 N  N   . ALA A 1 436 ? -26.104 -18.781 -41.374 1.00 18.04 ? 430 ALA A N   1 
ATOM   2949 C  CA  . ALA A 1 436 ? -25.873 -18.380 -42.759 1.00 18.81 ? 430 ALA A CA  1 
ATOM   2950 C  C   . ALA A 1 436 ? -25.211 -17.015 -42.821 1.00 16.10 ? 430 ALA A C   1 
ATOM   2951 O  O   . ALA A 1 436 ? -24.301 -16.792 -43.631 1.00 16.40 ? 430 ALA A O   1 
ATOM   2952 C  CB  . ALA A 1 436 ? -27.184 -18.364 -43.541 1.00 19.28 ? 430 ALA A CB  1 
ATOM   2953 N  N   . HIS A 1 437 ? -25.641 -16.090 -41.967 1.00 16.81 ? 431 HIS A N   1 
ATOM   2954 C  CA  . HIS A 1 437 ? -24.969 -14.801 -41.951 1.00 18.18 ? 431 HIS A CA  1 
ATOM   2955 C  C   . HIS A 1 437 ? -23.487 -14.971 -41.658 1.00 21.54 ? 431 HIS A C   1 
ATOM   2956 O  O   . HIS A 1 437 ? -22.641 -14.331 -42.299 1.00 18.87 ? 431 HIS A O   1 
ATOM   2957 C  CB  . HIS A 1 437 ? -25.581 -13.851 -40.929 1.00 19.49 ? 431 HIS A CB  1 
ATOM   2958 C  CG  . HIS A 1 437 ? -24.744 -12.627 -40.734 1.00 21.52 ? 431 HIS A CG  1 
ATOM   2959 N  ND1 . HIS A 1 437 ? -23.881 -12.469 -39.668 1.00 23.29 ? 431 HIS A ND1 1 
ATOM   2960 C  CD2 . HIS A 1 437 ? -24.559 -11.549 -41.533 1.00 22.56 ? 431 HIS A CD2 1 
ATOM   2961 C  CE1 . HIS A 1 437 ? -23.233 -11.324 -39.797 1.00 25.82 ? 431 HIS A CE1 1 
ATOM   2962 N  NE2 . HIS A 1 437 ? -23.627 -10.747 -40.920 1.00 26.42 ? 431 HIS A NE2 1 
ATOM   2963 N  N   . LEU A 1 438 ? -23.150 -15.835 -40.691 1.00 16.84 ? 432 LEU A N   1 
ATOM   2964 C  CA  . LEU A 1 438 ? -21.745 -16.110 -40.408 1.00 16.81 ? 432 LEU A CA  1 
ATOM   2965 C  C   . LEU A 1 438 ? -21.046 -16.659 -41.647 1.00 17.09 ? 432 LEU A C   1 
ATOM   2966 O  O   . LEU A 1 438 ? -19.957 -16.204 -42.012 1.00 18.41 ? 432 LEU A O   1 
ATOM   2967 C  CB  . LEU A 1 438 ? -21.606 -17.090 -39.224 1.00 12.77 ? 432 LEU A CB  1 
ATOM   2968 C  CG  . LEU A 1 438 ? -21.994 -16.545 -37.834 1.00 17.71 ? 432 LEU A CG  1 
ATOM   2969 C  CD1 . LEU A 1 438 ? -21.975 -17.630 -36.710 1.00 19.06 ? 432 LEU A CD1 1 
ATOM   2970 C  CD2 . LEU A 1 438 ? -21.138 -15.360 -37.433 1.00 13.18 ? 432 LEU A CD2 1 
ATOM   2971 N  N   . ALA A 1 439 ? -21.632 -17.675 -42.278 1.00 14.22 ? 433 ALA A N   1 
ATOM   2972 C  CA  . ALA A 1 439 ? -21.000 -18.267 -43.453 1.00 19.02 ? 433 ALA A CA  1 
ATOM   2973 C  C   . ALA A 1 439 ? -20.765 -17.218 -44.534 1.00 17.74 ? 433 ALA A C   1 
ATOM   2974 O  O   . ALA A 1 439 ? -19.744 -17.255 -45.230 1.00 18.58 ? 433 ALA A O   1 
ATOM   2975 C  CB  . ALA A 1 439 ? -21.856 -19.422 -44.000 1.00 13.98 ? 433 ALA A CB  1 
ATOM   2976 N  N   . ALA A 1 440 ? -21.689 -16.265 -44.674 1.00 15.32 ? 434 ALA A N   1 
ATOM   2977 C  CA  . ALA A 1 440 ? -21.607 -15.325 -45.782 1.00 19.74 ? 434 ALA A CA  1 
ATOM   2978 C  C   . ALA A 1 440 ? -20.526 -14.272 -45.575 1.00 22.47 ? 434 ALA A C   1 
ATOM   2979 O  O   . ALA A 1 440 ? -19.994 -13.753 -46.561 1.00 22.44 ? 434 ALA A O   1 
ATOM   2980 C  CB  . ALA A 1 440 ? -22.967 -14.658 -46.005 1.00 16.53 ? 434 ALA A CB  1 
ATOM   2981 N  N   . THR A 1 441 ? -20.207 -13.934 -44.316 1.00 20.33 ? 435 THR A N   1 
ATOM   2982 C  CA  . THR A 1 441 ? -19.247 -12.894 -43.957 1.00 18.79 ? 435 THR A CA  1 
ATOM   2983 C  C   . THR A 1 441 ? -17.896 -13.452 -43.493 1.00 18.28 ? 435 THR A C   1 
ATOM   2984 O  O   . THR A 1 441 ? -17.018 -12.673 -43.120 1.00 20.50 ? 435 THR A O   1 
ATOM   2985 C  CB  . THR A 1 441 ? -19.828 -11.991 -42.868 1.00 20.58 ? 435 THR A CB  1 
ATOM   2986 O  OG1 . THR A 1 441 ? -20.247 -12.794 -41.757 1.00 17.98 ? 435 THR A OG1 1 
ATOM   2987 C  CG2 . THR A 1 441 ? -21.033 -11.215 -43.382 1.00 21.94 ? 435 THR A CG2 1 
ATOM   2988 N  N   . GLN A 1 442 ? -17.699 -14.769 -43.558 1.00 20.64 ? 436 GLN A N   1 
ATOM   2989 C  CA  . GLN A 1 442 ? -16.429 -15.385 -43.174 1.00 19.02 ? 436 GLN A CA  1 
ATOM   2990 C  C   . GLN A 1 442 ? -15.295 -14.929 -44.083 1.00 24.25 ? 436 GLN A C   1 
ATOM   2991 O  O   . GLN A 1 442 ? -15.414 -14.975 -45.311 1.00 30.49 ? 436 GLN A O   1 
ATOM   2992 C  CB  . GLN A 1 442 ? -16.547 -16.907 -43.238 1.00 17.46 ? 436 GLN A CB  1 
ATOM   2993 C  CG  . GLN A 1 442 ? -15.353 -17.686 -42.659 1.00 18.84 ? 436 GLN A CG  1 
ATOM   2994 C  CD  . GLN A 1 442 ? -15.647 -19.179 -42.566 1.00 20.15 ? 436 GLN A CD  1 
ATOM   2995 O  OE1 . GLN A 1 442 ? -16.582 -19.672 -43.197 1.00 19.50 ? 436 GLN A OE1 1 
ATOM   2996 N  NE2 . GLN A 1 442 ? -14.879 -19.895 -41.738 1.00 19.05 ? 436 GLN A NE2 1 
ATOM   2997 N  N   . ASN A 1 443 ? -14.172 -14.538 -43.481 1.00 22.02 ? 437 ASN A N   1 
ATOM   2998 C  CA  . ASN A 1 443 ? -13.034 -14.075 -44.258 1.00 22.31 ? 437 ASN A CA  1 
ATOM   2999 C  C   . ASN A 1 443 ? -12.269 -15.239 -44.876 1.00 23.94 ? 437 ASN A C   1 
ATOM   3000 O  O   . ASN A 1 443 ? -12.381 -16.402 -44.465 1.00 22.93 ? 437 ASN A O   1 
ATOM   3001 C  CB  . ASN A 1 443 ? -12.077 -13.249 -43.406 1.00 20.46 ? 437 ASN A CB  1 
ATOM   3002 C  CG  . ASN A 1 443 ? -12.670 -11.941 -42.987 1.00 20.28 ? 437 ASN A CG  1 
ATOM   3003 O  OD1 . ASN A 1 443 ? -13.567 -11.410 -43.644 1.00 24.88 ? 437 ASN A OD1 1 
ATOM   3004 N  ND2 . ASN A 1 443 ? -12.197 -11.417 -41.861 1.00 20.75 ? 437 ASN A ND2 1 
ATOM   3005 N  N   . GLY A 1 444 ? -11.447 -14.890 -45.868 1.00 26.40 ? 438 GLY A N   1 
ATOM   3006 C  CA  . GLY A 1 444 ? -10.708 -15.895 -46.611 1.00 26.10 ? 438 GLY A CA  1 
ATOM   3007 C  C   . GLY A 1 444 ? -9.825  -16.766 -45.742 1.00 25.67 ? 438 GLY A C   1 
ATOM   3008 O  O   . GLY A 1 444 ? -9.675  -17.956 -46.017 1.00 20.66 ? 438 GLY A O   1 
ATOM   3009 N  N   . ASP A 1 445 ? -9.239  -16.199 -44.671 1.00 24.34 ? 439 ASP A N   1 
ATOM   3010 C  CA  . ASP A 1 445 ? -8.396  -17.001 -43.780 1.00 20.30 ? 439 ASP A CA  1 
ATOM   3011 C  C   . ASP A 1 445 ? -9.209  -17.876 -42.831 1.00 20.82 ? 439 ASP A C   1 
ATOM   3012 O  O   . ASP A 1 445 ? -8.626  -18.622 -42.028 1.00 19.63 ? 439 ASP A O   1 
ATOM   3013 C  CB  . ASP A 1 445 ? -7.422  -16.104 -42.981 1.00 22.91 ? 439 ASP A CB  1 
ATOM   3014 C  CG  . ASP A 1 445 ? -8.118  -15.001 -42.182 1.00 24.22 ? 439 ASP A CG  1 
ATOM   3015 O  OD1 . ASP A 1 445 ? -9.322  -15.111 -41.886 1.00 22.94 ? 439 ASP A OD1 1 
ATOM   3016 O  OD2 . ASP A 1 445 ? -7.444  -14.001 -41.835 1.00 28.58 ? 439 ASP A OD2 1 
ATOM   3017 N  N   . GLY A 1 446 ? -10.534 -17.830 -42.910 1.00 20.52 ? 440 GLY A N   1 
ATOM   3018 C  CA  . GLY A 1 446 ? -11.369 -18.678 -42.086 1.00 20.41 ? 440 GLY A CA  1 
ATOM   3019 C  C   . GLY A 1 446 ? -11.903 -18.023 -40.834 1.00 16.92 ? 440 GLY A C   1 
ATOM   3020 O  O   . GLY A 1 446 ? -12.737 -18.626 -40.151 1.00 16.77 ? 440 GLY A O   1 
ATOM   3021 N  N   . GLY A 1 447 ? -11.461 -16.807 -40.513 1.00 16.41 ? 441 GLY A N   1 
ATOM   3022 C  CA  . GLY A 1 447 ? -11.921 -16.120 -39.327 1.00 17.31 ? 441 GLY A CA  1 
ATOM   3023 C  C   . GLY A 1 447 ? -12.900 -15.002 -39.634 1.00 18.20 ? 441 GLY A C   1 
ATOM   3024 O  O   . GLY A 1 447 ? -13.321 -14.783 -40.771 1.00 22.24 ? 441 GLY A O   1 
ATOM   3025 N  N   . TRP A 1 448 ? -13.280 -14.296 -38.573 1.00 14.95 ? 442 TRP A N   1 
ATOM   3026 C  CA  . TRP A 1 448 ? -14.160 -13.145 -38.678 1.00 16.14 ? 442 TRP A CA  1 
ATOM   3027 C  C   . TRP A 1 448 ? -13.550 -11.972 -37.926 1.00 19.32 ? 442 TRP A C   1 
ATOM   3028 O  O   . TRP A 1 448 ? -12.883 -12.150 -36.899 1.00 19.40 ? 442 TRP A O   1 
ATOM   3029 C  CB  . TRP A 1 448 ? -15.538 -13.412 -38.099 1.00 13.83 ? 442 TRP A CB  1 
ATOM   3030 C  CG  . TRP A 1 448 ? -16.406 -14.352 -38.837 1.00 16.22 ? 442 TRP A CG  1 
ATOM   3031 C  CD1 . TRP A 1 448 ? -17.453 -14.027 -39.655 1.00 17.99 ? 442 TRP A CD1 1 
ATOM   3032 C  CD2 . TRP A 1 448 ? -16.359 -15.780 -38.790 1.00 14.15 ? 442 TRP A CD2 1 
ATOM   3033 N  NE1 . TRP A 1 448 ? -18.055 -15.172 -40.130 1.00 17.98 ? 442 TRP A NE1 1 
ATOM   3034 C  CE2 . TRP A 1 448 ? -17.398 -16.262 -39.615 1.00 17.46 ? 442 TRP A CE2 1 
ATOM   3035 C  CE3 . TRP A 1 448 ? -15.535 -16.701 -38.142 1.00 13.71 ? 442 TRP A CE3 1 
ATOM   3036 C  CZ2 . TRP A 1 448 ? -17.632 -17.624 -39.805 1.00 12.67 ? 442 TRP A CZ2 1 
ATOM   3037 C  CZ3 . TRP A 1 448 ? -15.771 -18.048 -38.333 1.00 16.01 ? 442 TRP A CZ3 1 
ATOM   3038 C  CH2 . TRP A 1 448 ? -16.811 -18.496 -39.153 1.00 14.98 ? 442 TRP A CH2 1 
ATOM   3039 N  N   . GLY A 1 449 ? -13.814 -10.763 -38.420 1.00 16.80 ? 443 GLY A N   1 
ATOM   3040 C  CA  . GLY A 1 449 ? -13.450 -9.551  -37.724 1.00 21.45 ? 443 GLY A CA  1 
ATOM   3041 C  C   . GLY A 1 449 ? -14.627 -8.917  -36.999 1.00 22.63 ? 443 GLY A C   1 
ATOM   3042 O  O   . GLY A 1 449 ? -15.709 -9.495  -36.881 1.00 20.46 ? 443 GLY A O   1 
ATOM   3043 N  N   . HIS A 1 450 ? -14.400 -7.677  -36.534 1.00 22.88 ? 444 HIS A N   1 
ATOM   3044 C  CA  . HIS A 1 450 ? -15.443 -6.909  -35.851 1.00 25.13 ? 444 HIS A CA  1 
ATOM   3045 C  C   . HIS A 1 450 ? -16.629 -6.607  -36.762 1.00 25.41 ? 444 HIS A C   1 
ATOM   3046 O  O   . HIS A 1 450 ? -17.775 -6.550  -36.298 1.00 25.16 ? 444 HIS A O   1 
ATOM   3047 C  CB  . HIS A 1 450 ? -14.854 -5.601  -35.302 1.00 26.67 ? 444 HIS A CB  1 
ATOM   3048 C  CG  . HIS A 1 450 ? -14.114 -5.774  -34.010 1.00 30.82 ? 444 HIS A CG  1 
ATOM   3049 N  ND1 . HIS A 1 450 ? -13.834 -4.723  -33.163 1.00 29.39 ? 444 HIS A ND1 1 
ATOM   3050 C  CD2 . HIS A 1 450 ? -13.604 -6.880  -33.417 1.00 28.88 ? 444 HIS A CD2 1 
ATOM   3051 C  CE1 . HIS A 1 450 ? -13.179 -5.171  -32.110 1.00 27.33 ? 444 HIS A CE1 1 
ATOM   3052 N  NE2 . HIS A 1 450 ? -13.036 -6.477  -32.233 1.00 27.98 ? 444 HIS A NE2 1 
ATOM   3053 N  N   . ALA A 1 451 ? -16.371 -6.422  -38.053 1.00 26.31 ? 445 ALA A N   1 
ATOM   3054 C  CA  . ALA A 1 451 ? -17.362 -6.087  -39.067 1.00 28.16 ? 445 ALA A CA  1 
ATOM   3055 C  C   . ALA A 1 451 ? -17.034 -6.906  -40.303 1.00 29.64 ? 445 ALA A C   1 
ATOM   3056 O  O   . ALA A 1 451 ? -15.911 -7.399  -40.445 1.00 29.17 ? 445 ALA A O   1 
ATOM   3057 C  CB  . ALA A 1 451 ? -17.350 -4.584  -39.381 1.00 22.56 ? 445 ALA A CB  1 
ATOM   3058 N  N   . GLU A 1 452 ? -18.020 -7.078  -41.197 1.00 29.65 ? 446 GLU A N   1 
ATOM   3059 C  CA  . GLU A 1 452 ? -17.839 -8.037  -42.291 1.00 31.03 ? 446 GLU A CA  1 
ATOM   3060 C  C   . GLU A 1 452 ? -16.588 -7.753  -43.103 1.00 30.67 ? 446 GLU A C   1 
ATOM   3061 O  O   . GLU A 1 452 ? -15.945 -8.684  -43.601 1.00 30.17 ? 446 GLU A O   1 
ATOM   3062 C  CB  . GLU A 1 452 ? -19.051 -8.053  -43.220 1.00 32.02 ? 446 GLU A CB  1 
ATOM   3063 C  CG  . GLU A 1 452 ? -19.734 -6.717  -43.354 1.00 38.14 ? 446 GLU A CG  1 
ATOM   3064 C  CD  . GLU A 1 452 ? -21.142 -6.862  -43.931 1.00 49.22 ? 446 GLU A CD  1 
ATOM   3065 O  OE1 . GLU A 1 452 ? -21.931 -7.667  -43.346 1.00 39.05 ? 446 GLU A OE1 1 
ATOM   3066 O  OE2 . GLU A 1 452 ? -21.428 -6.227  -44.988 1.00 37.48 ? 446 GLU A OE2 1 
ATOM   3067 N  N   . ALA A 1 453 ? -16.209 -6.486  -43.234 1.00 28.06 ? 447 ALA A N   1 
ATOM   3068 C  CA  . ALA A 1 453 ? -15.061 -6.148  -44.055 1.00 29.98 ? 447 ALA A CA  1 
ATOM   3069 C  C   . ALA A 1 453 ? -13.791 -5.963  -43.237 1.00 30.15 ? 447 ALA A C   1 
ATOM   3070 O  O   . ALA A 1 453 ? -12.789 -5.481  -43.773 1.00 38.68 ? 447 ALA A O   1 
ATOM   3071 C  CB  . ALA A 1 453 ? -15.362 -4.897  -44.894 1.00 26.25 ? 447 ALA A CB  1 
ATOM   3072 N  N   . GLU A 1 454 ? -13.793 -6.378  -41.943 1.00 28.94 ? 448 GLU A N   1 
ATOM   3073 C  CA  . GLU A 1 454 ? -12.645 -6.221  -41.063 1.00 28.15 ? 448 GLU A CA  1 
ATOM   3074 C  C   . GLU A 1 454 ? -11.736 -7.454  -41.085 1.00 26.26 ? 448 GLU A C   1 
ATOM   3075 O  O   . GLU A 1 454 ? -12.203 -8.580  -41.284 1.00 22.64 ? 448 GLU A O   1 
ATOM   3076 C  CB  . GLU A 1 454 ? -13.111 -5.970  -39.629 1.00 31.16 ? 448 GLU A CB  1 
ATOM   3077 C  CG  . GLU A 1 454 ? -13.855 -4.656  -39.418 1.00 35.28 ? 448 GLU A CG  1 
ATOM   3078 C  CD  . GLU A 1 454 ? -12.917 -3.472  -39.262 1.00 45.10 ? 448 GLU A CD  1 
ATOM   3079 O  OE1 . GLU A 1 454 ? -11.693 -3.689  -39.130 1.00 45.64 ? 448 GLU A OE1 1 
ATOM   3080 O  OE2 . GLU A 1 454 ? -13.408 -2.321  -39.256 1.00 57.97 ? 448 GLU A OE2 1 
ATOM   3081 N  N   . PRO A 1 455 ? -10.442 -7.251  -40.832 1.00 25.81 ? 449 PRO A N   1 
ATOM   3082 C  CA  . PRO A 1 455 ? -9.517  -8.387  -40.684 1.00 23.79 ? 449 PRO A CA  1 
ATOM   3083 C  C   . PRO A 1 455 ? -9.944  -9.307  -39.549 1.00 23.53 ? 449 PRO A C   1 
ATOM   3084 O  O   . PRO A 1 455 ? -10.476 -8.864  -38.536 1.00 23.89 ? 449 PRO A O   1 
ATOM   3085 C  CB  . PRO A 1 455 ? -8.173  -7.721  -40.354 1.00 27.69 ? 449 PRO A CB  1 
ATOM   3086 C  CG  . PRO A 1 455 ? -8.387  -6.226  -40.493 1.00 32.85 ? 449 PRO A CG  1 
ATOM   3087 C  CD  . PRO A 1 455 ? -9.847  -5.964  -40.431 1.00 25.31 ? 449 PRO A CD  1 
ATOM   3088 N  N   . SER A 1 456 ? -9.671  -10.600 -39.711 1.00 25.26 ? 450 SER A N   1 
ATOM   3089 C  CA  . SER A 1 456 ? -10.044 -11.584 -38.702 1.00 21.43 ? 450 SER A CA  1 
ATOM   3090 C  C   . SER A 1 456 ? -9.316  -11.337 -37.384 1.00 20.83 ? 450 SER A C   1 
ATOM   3091 O  O   . SER A 1 456 ? -8.209  -10.800 -37.354 1.00 22.87 ? 450 SER A O   1 
ATOM   3092 C  CB  . SER A 1 456 ? -9.729  -12.985 -39.203 1.00 17.43 ? 450 SER A CB  1 
ATOM   3093 O  OG  . SER A 1 456 ? -10.473 -13.251 -40.373 1.00 23.56 ? 450 SER A OG  1 
ATOM   3094 N  N   . ASP A 1 457 ? -9.956  -11.728 -36.280 1.00 23.05 ? 451 ASP A N   1 
ATOM   3095 C  CA  . ASP A 1 457 ? -9.293  -11.782 -34.978 1.00 19.69 ? 451 ASP A CA  1 
ATOM   3096 C  C   . ASP A 1 457 ? -9.837  -12.966 -34.191 1.00 17.99 ? 451 ASP A C   1 
ATOM   3097 O  O   . ASP A 1 457 ? -10.971 -13.401 -34.421 1.00 15.97 ? 451 ASP A O   1 
ATOM   3098 C  CB  . ASP A 1 457 ? -9.459  -10.485 -34.176 1.00 16.43 ? 451 ASP A CB  1 
ATOM   3099 C  CG  . ASP A 1 457 ? -10.879 -10.274 -33.684 1.00 20.94 ? 451 ASP A CG  1 
ATOM   3100 O  OD1 . ASP A 1 457 ? -11.223 -10.778 -32.593 1.00 23.80 ? 451 ASP A OD1 1 
ATOM   3101 O  OD2 . ASP A 1 457 ? -11.664 -9.612  -34.388 1.00 19.41 ? 451 ASP A OD2 1 
ATOM   3102 N  N   . PRO A 1 458 ? -9.039  -13.512 -33.272 1.00 18.38 ? 452 PRO A N   1 
ATOM   3103 C  CA  . PRO A 1 458 ? -9.425  -14.763 -32.598 1.00 14.67 ? 452 PRO A CA  1 
ATOM   3104 C  C   . PRO A 1 458 ? -10.686 -14.667 -31.758 1.00 17.54 ? 452 PRO A C   1 
ATOM   3105 O  O   . PRO A 1 458 ? -11.450 -15.640 -31.684 1.00 17.65 ? 452 PRO A O   1 
ATOM   3106 C  CB  . PRO A 1 458 ? -8.187  -15.068 -31.736 1.00 18.96 ? 452 PRO A CB  1 
ATOM   3107 C  CG  . PRO A 1 458 ? -7.050  -14.472 -32.545 1.00 22.57 ? 452 PRO A CG  1 
ATOM   3108 C  CD  . PRO A 1 458 ? -7.622  -13.171 -33.060 1.00 18.83 ? 452 PRO A CD  1 
ATOM   3109 N  N   . ILE A 1 459 ? -10.927 -13.532 -31.101 1.00 16.95 ? 453 ILE A N   1 
ATOM   3110 C  CA  . ILE A 1 459 ? -12.098 -13.434 -30.241 1.00 17.84 ? 453 ILE A CA  1 
ATOM   3111 C  C   . ILE A 1 459 ? -13.372 -13.408 -31.077 1.00 17.52 ? 453 ILE A C   1 
ATOM   3112 O  O   . ILE A 1 459 ? -14.323 -14.149 -30.801 1.00 15.86 ? 453 ILE A O   1 
ATOM   3113 C  CB  . ILE A 1 459 ? -12.005 -12.198 -29.330 1.00 18.53 ? 453 ILE A CB  1 
ATOM   3114 C  CG1 . ILE A 1 459 ? -10.870 -12.349 -28.315 1.00 15.12 ? 453 ILE A CG1 1 
ATOM   3115 C  CG2 . ILE A 1 459 ? -13.321 -12.009 -28.611 1.00 19.85 ? 453 ILE A CG2 1 
ATOM   3116 C  CD1 . ILE A 1 459 ? -10.660 -11.075 -27.443 1.00 18.04 ? 453 ILE A CD1 1 
ATOM   3117 N  N   . SER A 1 460 ? -13.424 -12.539 -32.098 1.00 13.53 ? 454 SER A N   1 
ATOM   3118 C  CA  . SER A 1 460 ? -14.581 -12.556 -32.993 1.00 16.19 ? 454 SER A CA  1 
ATOM   3119 C  C   . SER A 1 460 ? -14.780 -13.940 -33.593 1.00 14.02 ? 454 SER A C   1 
ATOM   3120 O  O   . SER A 1 460 ? -15.916 -14.403 -33.749 1.00 13.87 ? 454 SER A O   1 
ATOM   3121 C  CB  . SER A 1 460 ? -14.421 -11.539 -34.120 1.00 19.23 ? 454 SER A CB  1 
ATOM   3122 O  OG  . SER A 1 460 ? -14.276 -10.217 -33.652 1.00 19.80 ? 454 SER A OG  1 
ATOM   3123 N  N   . THR A 1 461 ? -13.681 -14.605 -33.966 1.00 13.41 ? 455 THR A N   1 
ATOM   3124 C  CA  . THR A 1 461 ? -13.791 -15.946 -34.538 1.00 16.24 ? 455 THR A CA  1 
ATOM   3125 C  C   . THR A 1 461 ? -14.301 -16.942 -33.507 1.00 14.98 ? 455 THR A C   1 
ATOM   3126 O  O   . THR A 1 461 ? -15.127 -17.809 -33.826 1.00 14.38 ? 455 THR A O   1 
ATOM   3127 C  CB  . THR A 1 461 ? -12.438 -16.392 -35.100 1.00 16.19 ? 455 THR A CB  1 
ATOM   3128 O  OG1 . THR A 1 461 ? -11.998 -15.435 -36.075 1.00 15.16 ? 455 THR A OG1 1 
ATOM   3129 C  CG2 . THR A 1 461 ? -12.540 -17.782 -35.757 1.00 14.98 ? 455 THR A CG2 1 
ATOM   3130 N  N   . ALA A 1 462 ? -13.842 -16.808 -32.258 1.00 13.10 ? 456 ALA A N   1 
ATOM   3131 C  CA  . ALA A 1 462 ? -14.263 -17.729 -31.208 1.00 17.54 ? 456 ALA A CA  1 
ATOM   3132 C  C   . ALA A 1 462 ? -15.775 -17.681 -31.016 1.00 16.11 ? 456 ALA A C   1 
ATOM   3133 O  O   . ALA A 1 462 ? -16.434 -18.723 -30.920 1.00 16.96 ? 456 ALA A O   1 
ATOM   3134 C  CB  . ALA A 1 462 ? -13.532 -17.404 -29.898 1.00 13.68 ? 456 ALA A CB  1 
ATOM   3135 N  N   . TYR A 1 463 ? -16.348 -16.477 -30.958 1.00 15.01 ? 457 TYR A N   1 
ATOM   3136 C  CA  . TYR A 1 463 ? -17.800 -16.369 -30.847 1.00 18.14 ? 457 TYR A CA  1 
ATOM   3137 C  C   . TYR A 1 463 ? -18.489 -17.103 -32.001 1.00 17.60 ? 457 TYR A C   1 
ATOM   3138 O  O   . TYR A 1 463 ? -19.440 -17.862 -31.787 1.00 16.09 ? 457 TYR A O   1 
ATOM   3139 C  CB  . TYR A 1 463 ? -18.225 -14.896 -30.831 1.00 17.38 ? 457 TYR A CB  1 
ATOM   3140 C  CG  . TYR A 1 463 ? -17.725 -14.050 -29.664 1.00 21.14 ? 457 TYR A CG  1 
ATOM   3141 C  CD1 . TYR A 1 463 ? -17.413 -14.614 -28.434 1.00 19.48 ? 457 TYR A CD1 1 
ATOM   3142 C  CD2 . TYR A 1 463 ? -17.562 -12.684 -29.810 1.00 20.47 ? 457 TYR A CD2 1 
ATOM   3143 C  CE1 . TYR A 1 463 ? -16.957 -13.838 -27.388 1.00 21.60 ? 457 TYR A CE1 1 
ATOM   3144 C  CE2 . TYR A 1 463 ? -17.118 -11.907 -28.778 1.00 20.96 ? 457 TYR A CE2 1 
ATOM   3145 C  CZ  . TYR A 1 463 ? -16.812 -12.490 -27.559 1.00 26.07 ? 457 TYR A CZ  1 
ATOM   3146 O  OH  . TYR A 1 463 ? -16.361 -11.698 -26.514 1.00 25.96 ? 457 TYR A OH  1 
ATOM   3147 N  N   . ALA A 1 464 ? -18.035 -16.859 -33.238 1.00 12.23 ? 458 ALA A N   1 
ATOM   3148 C  CA  . ALA A 1 464 ? -18.639 -17.509 -34.403 1.00 17.98 ? 458 ALA A CA  1 
ATOM   3149 C  C   . ALA A 1 464 ? -18.564 -19.027 -34.286 1.00 16.86 ? 458 ALA A C   1 
ATOM   3150 O  O   . ALA A 1 464 ? -19.531 -19.728 -34.603 1.00 15.30 ? 458 ALA A O   1 
ATOM   3151 C  CB  . ALA A 1 464 ? -17.951 -17.050 -35.692 1.00 11.82 ? 458 ALA A CB  1 
ATOM   3152 N  N   . VAL A 1 465 ? -17.427 -19.549 -33.816 1.00 16.13 ? 459 VAL A N   1 
ATOM   3153 C  CA  . VAL A 1 465 ? -17.284 -20.994 -33.665 1.00 16.43 ? 459 VAL A CA  1 
ATOM   3154 C  C   . VAL A 1 465 ? -18.295 -21.536 -32.659 1.00 16.59 ? 459 VAL A C   1 
ATOM   3155 O  O   . VAL A 1 465 ? -18.895 -22.590 -32.876 1.00 20.34 ? 459 VAL A O   1 
ATOM   3156 C  CB  . VAL A 1 465 ? -15.836 -21.343 -33.270 1.00 16.90 ? 459 VAL A CB  1 
ATOM   3157 C  CG1 . VAL A 1 465 ? -15.768 -22.731 -32.688 1.00 19.44 ? 459 VAL A CG1 1 
ATOM   3158 C  CG2 . VAL A 1 465 ? -14.914 -21.208 -34.469 1.00 14.85 ? 459 VAL A CG2 1 
ATOM   3159 N  N   . ILE A 1 466 ? -18.489 -20.851 -31.527 1.00 18.54 ? 460 ILE A N   1 
ATOM   3160 C  CA  . ILE A 1 466 ? -19.469 -21.349 -30.561 1.00 15.09 ? 460 ILE A CA  1 
ATOM   3161 C  C   . ILE A 1 466 ? -20.839 -21.488 -31.223 1.00 17.32 ? 460 ILE A C   1 
ATOM   3162 O  O   . ILE A 1 466 ? -21.523 -22.507 -31.077 1.00 16.75 ? 460 ILE A O   1 
ATOM   3163 C  CB  . ILE A 1 466 ? -19.528 -20.436 -29.320 1.00 19.54 ? 460 ILE A CB  1 
ATOM   3164 C  CG1 . ILE A 1 466 ? -18.181 -20.371 -28.605 1.00 15.91 ? 460 ILE A CG1 1 
ATOM   3165 C  CG2 . ILE A 1 466 ? -20.575 -20.940 -28.327 1.00 17.41 ? 460 ILE A CG2 1 
ATOM   3166 C  CD1 . ILE A 1 466 ? -18.122 -19.263 -27.572 1.00 18.36 ? 460 ILE A CD1 1 
ATOM   3167 N  N   . ALA A 1 467 ? -21.269 -20.447 -31.942 1.00 15.96 ? 461 ALA A N   1 
ATOM   3168 C  CA  . ALA A 1 467 ? -22.515 -20.498 -32.700 1.00 16.32 ? 461 ALA A CA  1 
ATOM   3169 C  C   . ALA A 1 467 ? -22.520 -21.663 -33.679 1.00 17.38 ? 461 ALA A C   1 
ATOM   3170 O  O   . ALA A 1 467 ? -23.478 -22.438 -33.736 1.00 19.41 ? 461 ALA A O   1 
ATOM   3171 C  CB  . ALA A 1 467 ? -22.708 -19.176 -33.452 1.00 15.59 ? 461 ALA A CB  1 
ATOM   3172 N  N   . LEU A 1 468 ? -21.456 -21.801 -34.466 1.00 16.52 ? 462 LEU A N   1 
ATOM   3173 C  CA  . LEU A 1 468 ? -21.453 -22.821 -35.516 1.00 20.19 ? 462 LEU A CA  1 
ATOM   3174 C  C   . LEU A 1 468 ? -21.434 -24.234 -34.933 1.00 23.36 ? 462 LEU A C   1 
ATOM   3175 O  O   . LEU A 1 468 ? -22.096 -25.129 -35.463 1.00 22.20 ? 462 LEU A O   1 
ATOM   3176 C  CB  . LEU A 1 468 ? -20.272 -22.598 -36.456 1.00 17.50 ? 462 LEU A CB  1 
ATOM   3177 C  CG  . LEU A 1 468 ? -20.426 -21.406 -37.403 1.00 19.12 ? 462 LEU A CG  1 
ATOM   3178 C  CD1 . LEU A 1 468 ? -19.046 -20.957 -37.875 1.00 21.55 ? 462 LEU A CD1 1 
ATOM   3179 C  CD2 . LEU A 1 468 ? -21.306 -21.749 -38.601 1.00 17.87 ? 462 LEU A CD2 1 
ATOM   3180 N  N   . ALA A 1 469 ? -20.705 -24.452 -33.832 1.00 19.26 ? 463 ALA A N   1 
ATOM   3181 C  CA  . ALA A 1 469 ? -20.731 -25.762 -33.185 1.00 25.32 ? 463 ALA A CA  1 
ATOM   3182 C  C   . ALA A 1 469 ? -22.148 -26.214 -32.848 1.00 27.36 ? 463 ALA A C   1 
ATOM   3183 O  O   . ALA A 1 469 ? -22.365 -27.402 -32.601 1.00 29.48 ? 463 ALA A O   1 
ATOM   3184 C  CB  . ALA A 1 469 ? -19.880 -25.760 -31.918 1.00 21.47 ? 463 ALA A CB  1 
ATOM   3185 N  N   . ARG A 1 470 ? -23.117 -25.304 -32.844 1.00 30.51 ? 464 ARG A N   1 
ATOM   3186 C  CA  . ARG A 1 470 ? -24.521 -25.667 -32.682 1.00 31.61 ? 464 ARG A CA  1 
ATOM   3187 C  C   . ARG A 1 470 ? -25.213 -25.990 -33.999 1.00 29.81 ? 464 ARG A C   1 
ATOM   3188 O  O   . ARG A 1 470 ? -26.386 -26.368 -33.983 1.00 34.66 ? 464 ARG A O   1 
ATOM   3189 C  CB  . ARG A 1 470 ? -25.278 -24.541 -31.982 1.00 27.73 ? 464 ARG A CB  1 
ATOM   3190 C  CG  . ARG A 1 470 ? -25.022 -24.516 -30.473 1.00 33.10 ? 464 ARG A CG  1 
ATOM   3191 C  CD  . ARG A 1 470 ? -25.497 -25.822 -29.846 1.00 30.55 ? 464 ARG A CD  1 
ATOM   3192 N  NE  . ARG A 1 470 ? -25.065 -25.927 -28.459 1.00 39.99 ? 464 ARG A NE  1 
ATOM   3193 C  CZ  . ARG A 1 470 ? -25.706 -25.378 -27.439 1.00 37.54 ? 464 ARG A CZ  1 
ATOM   3194 N  NH1 . ARG A 1 470 ? -26.837 -24.715 -27.610 1.00 38.45 ? 464 ARG A NH1 1 
ATOM   3195 N  NH2 . ARG A 1 470 ? -25.193 -25.486 -26.218 1.00 40.83 ? 464 ARG A NH2 1 
ATOM   3196 N  N   . GLY A 1 471 ? -24.530 -25.844 -35.127 1.00 25.57 ? 465 GLY A N   1 
ATOM   3197 C  CA  . GLY A 1 471 ? -25.124 -26.139 -36.407 1.00 37.01 ? 465 GLY A CA  1 
ATOM   3198 C  C   . GLY A 1 471 ? -24.855 -27.573 -36.812 1.00 41.04 ? 465 GLY A C   1 
ATOM   3199 O  O   . GLY A 1 471 ? -24.514 -28.418 -35.975 1.00 40.96 ? 465 GLY A O   1 
ATOM   3200 N  N   . PRO A 1 472 ? -24.943 -27.895 -38.126 1.00 41.39 ? 466 PRO A N   1 
ATOM   3201 C  CA  . PRO A 1 472 ? -24.610 -29.229 -38.622 1.00 46.27 ? 466 PRO A CA  1 
ATOM   3202 C  C   . PRO A 1 472 ? -23.148 -29.649 -38.428 1.00 52.51 ? 466 PRO A C   1 
ATOM   3203 O  O   . PRO A 1 472 ? -22.300 -28.796 -38.280 1.00 50.60 ? 466 PRO A O   1 
ATOM   3204 C  CB  . PRO A 1 472 ? -24.832 -29.134 -40.137 1.00 47.84 ? 466 PRO A CB  1 
ATOM   3205 C  CG  . PRO A 1 472 ? -24.720 -27.662 -40.434 1.00 47.41 ? 466 PRO A CG  1 
ATOM   3206 C  CD  . PRO A 1 472 ? -25.371 -27.019 -39.231 1.00 45.67 ? 466 PRO A CD  1 
ATOM   3207 N  N   . ARG A 1 473 ? -22.892 -30.954 -38.492 1.00 57.48 ? 467 ARG A N   1 
ATOM   3208 C  CA  . ARG A 1 473 ? -21.529 -31.496 -38.249 1.00 58.63 ? 467 ARG A CA  1 
ATOM   3209 C  C   . ARG A 1 473 ? -20.497 -30.849 -39.177 1.00 54.15 ? 467 ARG A C   1 
ATOM   3210 O  O   . ARG A 1 473 ? -20.791 -30.658 -40.367 1.00 53.97 ? 467 ARG A O   1 
ATOM   3211 C  CB  . ARG A 1 473 ? -21.541 -33.027 -38.375 1.00 57.68 ? 467 ARG A CB  1 
ATOM   3212 C  CG  . ARG A 1 473 ? -20.565 -33.746 -37.457 1.00 63.60 ? 467 ARG A CG  1 
ATOM   3213 C  CD  . ARG A 1 473 ? -19.167 -33.832 -38.041 1.00 68.61 ? 467 ARG A CD  1 
ATOM   3214 N  NE  . ARG A 1 473 ? -19.135 -34.596 -39.278 1.00 70.93 ? 467 ARG A NE  1 
ATOM   3215 C  CZ  . ARG A 1 473 ? -18.033 -35.067 -39.847 1.00 73.05 ? 467 ARG A CZ  1 
ATOM   3216 N  NH1 . ARG A 1 473 ? -16.853 -34.847 -39.291 1.00 70.68 ? 467 ARG A NH1 1 
ATOM   3217 N  NH2 . ARG A 1 473 ? -18.112 -35.753 -40.973 1.00 72.20 ? 467 ARG A NH2 1 
ATOM   3218 N  N   . ALA A 1 474 ? -19.322 -30.557 -38.631 1.00 56.99 ? 468 ALA A N   1 
ATOM   3219 C  CA  . ALA A 1 474 ? -18.218 -29.957 -39.406 1.00 52.46 ? 468 ALA A CA  1 
ATOM   3220 C  C   . ALA A 1 474 ? -17.858 -30.863 -40.582 1.00 56.93 ? 468 ALA A C   1 
ATOM   3221 O  O   . ALA A 1 474 ? -17.324 -31.955 -40.349 1.00 57.66 ? 468 ALA A O   1 
ATOM   3222 C  CB  . ALA A 1 474 ? -17.041 -29.762 -38.494 1.00 41.88 ? 468 ALA A CB  1 
ATOM   3223 N  N   . ARG A 1 475 ? -18.171 -30.424 -41.793 1.00 53.24 ? 469 ARG A N   1 
ATOM   3224 C  CA  . ARG A 1 475 ? -17.797 -31.204 -42.993 1.00 50.75 ? 469 ARG A CA  1 
ATOM   3225 C  C   . ARG A 1 475 ? -16.464 -30.644 -43.458 1.00 48.01 ? 469 ARG A C   1 
ATOM   3226 O  O   . ARG A 1 475 ? -16.189 -29.472 -43.198 1.00 43.57 ? 469 ARG A O   1 
ATOM   3227 C  CB  . ARG A 1 475 ? -18.869 -31.093 -44.077 1.00 45.29 ? 469 ARG A CB  1 
ATOM   3228 C  CG  . ARG A 1 475 ? -19.381 -29.680 -44.308 1.00 46.39 ? 469 ARG A CG  1 
ATOM   3229 C  CD  . ARG A 1 475 ? -19.084 -29.226 -45.721 1.00 43.31 ? 469 ARG A CD  1 
ATOM   3230 N  NE  . ARG A 1 475 ? -19.636 -27.910 -45.986 1.00 41.56 ? 469 ARG A NE  1 
ATOM   3231 C  CZ  . ARG A 1 475 ? -19.087 -27.016 -46.794 1.00 45.20 ? 469 ARG A CZ  1 
ATOM   3232 N  NH1 . ARG A 1 475 ? -17.961 -27.296 -47.425 1.00 42.90 ? 469 ARG A NH1 1 
ATOM   3233 N  NH2 . ARG A 1 475 ? -19.667 -25.843 -46.963 1.00 40.75 ? 469 ARG A NH2 1 
ATOM   3234 N  N   . PRO A 1 476 ? -15.617 -31.455 -44.104 1.00 49.44 ? 470 PRO A N   1 
ATOM   3235 C  CA  . PRO A 1 476 ? -14.323 -30.976 -44.513 1.00 45.50 ? 470 PRO A CA  1 
ATOM   3236 C  C   . PRO A 1 476 ? -14.515 -29.686 -45.316 1.00 44.64 ? 470 PRO A C   1 
ATOM   3237 O  O   . PRO A 1 476 ? -15.400 -29.650 -46.142 1.00 41.99 ? 470 PRO A O   1 
ATOM   3238 C  CB  . PRO A 1 476 ? -13.762 -32.132 -45.349 1.00 42.47 ? 470 PRO A CB  1 
ATOM   3239 C  CG  . PRO A 1 476 ? -14.487 -33.350 -44.834 1.00 50.52 ? 470 PRO A CG  1 
ATOM   3240 C  CD  . PRO A 1 476 ? -15.862 -32.853 -44.445 1.00 50.92 ? 470 PRO A CD  1 
ATOM   3241 N  N   . GLY A 1 477 ? -13.689 -28.679 -45.038 1.00 41.37 ? 471 GLY A N   1 
ATOM   3242 C  CA  . GLY A 1 477 ? -13.753 -27.407 -45.728 1.00 28.21 ? 471 GLY A CA  1 
ATOM   3243 C  C   . GLY A 1 477 ? -15.008 -26.606 -45.482 1.00 30.35 ? 471 GLY A C   1 
ATOM   3244 O  O   . GLY A 1 477 ? -15.211 -25.586 -46.160 1.00 34.94 ? 471 GLY A O   1 
ATOM   3245 N  N   . GLY A 1 478 ? -15.873 -27.044 -44.566 1.00 29.51 ? 472 GLY A N   1 
ATOM   3246 C  CA  . GLY A 1 478 ? -17.013 -26.261 -44.140 1.00 33.28 ? 472 GLY A CA  1 
ATOM   3247 C  C   . GLY A 1 478 ? -16.591 -25.032 -43.345 1.00 30.01 ? 472 GLY A C   1 
ATOM   3248 O  O   . GLY A 1 478 ? -15.418 -24.866 -42.995 1.00 24.66 ? 472 GLY A O   1 
ATOM   3249 N  N   . PRO A 1 479 ? -17.543 -24.135 -43.062 1.00 30.70 ? 473 PRO A N   1 
ATOM   3250 C  CA  . PRO A 1 479 ? -17.175 -22.908 -42.323 1.00 23.65 ? 473 PRO A CA  1 
ATOM   3251 C  C   . PRO A 1 479 ? -16.589 -23.173 -40.942 1.00 23.57 ? 473 PRO A C   1 
ATOM   3252 O  O   . PRO A 1 479 ? -15.585 -22.546 -40.579 1.00 20.59 ? 473 PRO A O   1 
ATOM   3253 C  CB  . PRO A 1 479 ? -18.491 -22.113 -42.258 1.00 25.10 ? 473 PRO A CB  1 
ATOM   3254 C  CG  . PRO A 1 479 ? -19.551 -22.977 -42.919 1.00 29.66 ? 473 PRO A CG  1 
ATOM   3255 C  CD  . PRO A 1 479 ? -18.869 -24.051 -43.698 1.00 25.69 ? 473 PRO A CD  1 
ATOM   3256 N  N   . LEU A 1 480 ? -17.175 -24.091 -40.164 1.00 22.33 ? 474 LEU A N   1 
ATOM   3257 C  CA  . LEU A 1 480 ? -16.653 -24.386 -38.832 1.00 20.45 ? 474 LEU A CA  1 
ATOM   3258 C  C   . LEU A 1 480 ? -15.255 -24.981 -38.918 1.00 23.41 ? 474 LEU A C   1 
ATOM   3259 O  O   . LEU A 1 480 ? -14.328 -24.533 -38.228 1.00 19.40 ? 474 LEU A O   1 
ATOM   3260 C  CB  . LEU A 1 480 ? -17.609 -25.328 -38.097 1.00 22.91 ? 474 LEU A CB  1 
ATOM   3261 C  CG  . LEU A 1 480 ? -17.203 -25.908 -36.731 1.00 24.42 ? 474 LEU A CG  1 
ATOM   3262 C  CD1 . LEU A 1 480 ? -16.931 -24.828 -35.690 1.00 16.43 ? 474 LEU A CD1 1 
ATOM   3263 C  CD2 . LEU A 1 480 ? -18.264 -26.880 -36.199 1.00 22.15 ? 474 LEU A CD2 1 
ATOM   3264 N  N   . ASP A 1 481 ? -15.083 -25.983 -39.786 1.00 24.81 ? 475 ASP A N   1 
ATOM   3265 C  CA  . ASP A 1 481 ? -13.774 -26.586 -40.009 1.00 20.95 ? 475 ASP A CA  1 
ATOM   3266 C  C   . ASP A 1 481 ? -12.719 -25.532 -40.310 1.00 22.44 ? 475 ASP A C   1 
ATOM   3267 O  O   . ASP A 1 481 ? -11.617 -25.566 -39.749 1.00 24.57 ? 475 ASP A O   1 
ATOM   3268 C  CB  . ASP A 1 481 ? -13.876 -27.599 -41.152 1.00 33.00 ? 475 ASP A CB  1 
ATOM   3269 C  CG  . ASP A 1 481 ? -12.637 -28.448 -41.294 1.00 37.82 ? 475 ASP A CG  1 
ATOM   3270 O  OD1 . ASP A 1 481 ? -12.253 -29.071 -40.282 1.00 51.53 ? 475 ASP A OD1 1 
ATOM   3271 O  OD2 . ASP A 1 481 ? -12.059 -28.513 -42.402 1.00 39.29 ? 475 ASP A OD2 1 
ATOM   3272 N  N   . ARG A 1 482 ? -13.049 -24.567 -41.167 1.00 18.21 ? 476 ARG A N   1 
ATOM   3273 C  CA  . ARG A 1 482 ? -12.075 -23.549 -41.551 1.00 21.65 ? 476 ARG A CA  1 
ATOM   3274 C  C   . ARG A 1 482 ? -11.797 -22.562 -40.418 1.00 21.69 ? 476 ARG A C   1 
ATOM   3275 O  O   . ARG A 1 482 ? -10.684 -22.038 -40.319 1.00 20.03 ? 476 ARG A O   1 
ATOM   3276 C  CB  . ARG A 1 482 ? -12.563 -22.801 -42.799 1.00 22.02 ? 476 ARG A CB  1 
ATOM   3277 C  CG  . ARG A 1 482 ? -12.428 -23.610 -44.090 1.00 32.15 ? 476 ARG A CG  1 
ATOM   3278 C  CD  . ARG A 1 482 ? -13.058 -22.897 -45.291 1.00 29.34 ? 476 ARG A CD  1 
ATOM   3279 N  NE  . ARG A 1 482 ? -12.612 -21.513 -45.391 1.00 29.93 ? 476 ARG A NE  1 
ATOM   3280 C  CZ  . ARG A 1 482 ? -13.423 -20.493 -45.630 1.00 32.57 ? 476 ARG A CZ  1 
ATOM   3281 N  NH1 . ARG A 1 482 ? -14.723 -20.675 -45.804 1.00 32.66 ? 476 ARG A NH1 1 
ATOM   3282 N  NH2 . ARG A 1 482 ? -12.920 -19.260 -45.695 1.00 27.63 ? 476 ARG A NH2 1 
ATOM   3283 N  N   . ALA A 1 483 ? -12.791 -22.292 -39.567 1.00 19.30 ? 477 ALA A N   1 
ATOM   3284 C  CA  . ALA A 1 483 ? -12.574 -21.403 -38.429 1.00 20.94 ? 477 ALA A CA  1 
ATOM   3285 C  C   . ALA A 1 483 ? -11.703 -22.081 -37.383 1.00 22.76 ? 477 ALA A C   1 
ATOM   3286 O  O   . ALA A 1 483 ? -10.837 -21.442 -36.771 1.00 18.68 ? 477 ALA A O   1 
ATOM   3287 C  CB  . ALA A 1 483 ? -13.914 -20.992 -37.825 1.00 14.42 ? 477 ALA A CB  1 
ATOM   3288 N  N   . LEU A 1 484 ? -11.928 -23.380 -37.164 1.00 21.16 ? 478 LEU A N   1 
ATOM   3289 C  CA  . LEU A 1 484 ? -11.042 -24.143 -36.294 1.00 18.26 ? 478 LEU A CA  1 
ATOM   3290 C  C   . LEU A 1 484 ? -9.611  -24.097 -36.812 1.00 20.98 ? 478 LEU A C   1 
ATOM   3291 O  O   . LEU A 1 484 ? -8.663  -23.911 -36.034 1.00 21.69 ? 478 LEU A O   1 
ATOM   3292 C  CB  . LEU A 1 484 ? -11.542 -25.588 -36.186 1.00 14.84 ? 478 LEU A CB  1 
ATOM   3293 C  CG  . LEU A 1 484 ? -12.851 -25.756 -35.418 1.00 18.18 ? 478 LEU A CG  1 
ATOM   3294 C  CD1 . LEU A 1 484 ? -13.242 -27.240 -35.238 1.00 15.56 ? 478 LEU A CD1 1 
ATOM   3295 C  CD2 . LEU A 1 484 ? -12.735 -25.055 -34.045 1.00 21.44 ? 478 LEU A CD2 1 
ATOM   3296 N  N   . ALA A 1 485 ? -9.427  -24.278 -38.126 1.00 19.78 ? 479 ALA A N   1 
ATOM   3297 C  CA  . ALA A 1 485 ? -8.082  -24.223 -38.681 1.00 19.66 ? 479 ALA A CA  1 
ATOM   3298 C  C   . ALA A 1 485 ? -7.475  -22.847 -38.466 1.00 23.66 ? 479 ALA A C   1 
ATOM   3299 O  O   . ALA A 1 485 ? -6.263  -22.715 -38.259 1.00 21.44 ? 479 ALA A O   1 
ATOM   3300 C  CB  . ALA A 1 485 ? -8.108  -24.582 -40.160 1.00 17.28 ? 479 ALA A CB  1 
ATOM   3301 N  N   . TYR A 1 486 ? -8.307  -21.810 -38.519 1.00 21.35 ? 480 TYR A N   1 
ATOM   3302 C  CA  . TYR A 1 486 ? -7.830  -20.467 -38.249 1.00 18.95 ? 480 TYR A CA  1 
ATOM   3303 C  C   . TYR A 1 486 ? -7.349  -20.336 -36.806 1.00 21.13 ? 480 TYR A C   1 
ATOM   3304 O  O   . TYR A 1 486 ? -6.309  -19.724 -36.552 1.00 20.54 ? 480 TYR A O   1 
ATOM   3305 C  CB  . TYR A 1 486 ? -8.937  -19.461 -38.554 1.00 20.22 ? 480 TYR A CB  1 
ATOM   3306 C  CG  . TYR A 1 486 ? -8.625  -18.072 -38.061 1.00 20.20 ? 480 TYR A CG  1 
ATOM   3307 C  CD1 . TYR A 1 486 ? -8.927  -17.705 -36.752 1.00 18.03 ? 480 TYR A CD1 1 
ATOM   3308 C  CD2 . TYR A 1 486 ? -8.032  -17.124 -38.895 1.00 17.60 ? 480 TYR A CD2 1 
ATOM   3309 C  CE1 . TYR A 1 486 ? -8.644  -16.445 -36.288 1.00 19.41 ? 480 TYR A CE1 1 
ATOM   3310 C  CE2 . TYR A 1 486 ? -7.733  -15.833 -38.426 1.00 17.73 ? 480 TYR A CE2 1 
ATOM   3311 C  CZ  . TYR A 1 486 ? -8.041  -15.516 -37.118 1.00 22.45 ? 480 TYR A CZ  1 
ATOM   3312 O  OH  . TYR A 1 486 ? -7.784  -14.265 -36.600 1.00 23.75 ? 480 TYR A OH  1 
ATOM   3313 N  N   . LEU A 1 487 ? -8.096  -20.900 -35.844 1.00 20.09 ? 481 LEU A N   1 
ATOM   3314 C  CA  . LEU A 1 487 ? -7.694  -20.796 -34.440 1.00 22.19 ? 481 LEU A CA  1 
ATOM   3315 C  C   . LEU A 1 487 ? -6.432  -21.621 -34.168 1.00 21.26 ? 481 LEU A C   1 
ATOM   3316 O  O   . LEU A 1 487 ? -5.525  -21.170 -33.457 1.00 22.46 ? 481 LEU A O   1 
ATOM   3317 C  CB  . LEU A 1 487 ? -8.857  -21.221 -33.523 1.00 18.83 ? 481 LEU A CB  1 
ATOM   3318 C  CG  . LEU A 1 487 ? -10.084 -20.279 -33.457 1.00 17.82 ? 481 LEU A CG  1 
ATOM   3319 C  CD1 . LEU A 1 487 ? -11.214 -20.863 -32.637 1.00 18.19 ? 481 LEU A CD1 1 
ATOM   3320 C  CD2 . LEU A 1 487 ? -9.742  -18.906 -32.897 1.00 14.63 ? 481 LEU A CD2 1 
ATOM   3321 N  N   . VAL A 1 488 ? -6.339  -22.819 -34.738 1.00 21.14 ? 482 VAL A N   1 
ATOM   3322 C  CA  . VAL A 1 488 ? -5.115  -23.607 -34.606 1.00 23.02 ? 482 VAL A CA  1 
ATOM   3323 C  C   . VAL A 1 488 ? -3.912  -22.804 -35.087 1.00 26.30 ? 482 VAL A C   1 
ATOM   3324 O  O   . VAL A 1 488 ? -2.897  -22.696 -34.391 1.00 24.69 ? 482 VAL A O   1 
ATOM   3325 C  CB  . VAL A 1 488 ? -5.242  -24.937 -35.374 1.00 25.26 ? 482 VAL A CB  1 
ATOM   3326 C  CG1 . VAL A 1 488 ? -3.889  -25.644 -35.452 1.00 20.49 ? 482 VAL A CG1 1 
ATOM   3327 C  CG2 . VAL A 1 488 ? -6.302  -25.815 -34.751 1.00 18.47 ? 482 VAL A CG2 1 
ATOM   3328 N  N   . GLU A 1 489 ? -4.008  -22.216 -36.282 1.00 23.22 ? 483 GLU A N   1 
ATOM   3329 C  CA  . GLU A 1 489 ? -2.842  -21.542 -36.841 1.00 28.29 ? 483 GLU A CA  1 
ATOM   3330 C  C   . GLU A 1 489 ? -2.450  -20.289 -36.062 1.00 30.01 ? 483 GLU A C   1 
ATOM   3331 O  O   . GLU A 1 489 ? -1.288  -19.875 -36.139 1.00 32.07 ? 483 GLU A O   1 
ATOM   3332 C  CB  . GLU A 1 489 ? -3.075  -21.191 -38.319 1.00 30.50 ? 483 GLU A CB  1 
ATOM   3333 C  CG  . GLU A 1 489 ? -2.436  -19.876 -38.739 1.00 37.40 ? 483 GLU A CG  1 
ATOM   3334 C  CD  . GLU A 1 489 ? -1.007  -20.032 -39.281 1.00 53.15 ? 483 GLU A CD  1 
ATOM   3335 O  OE1 . GLU A 1 489 ? -0.582  -21.182 -39.569 1.00 52.57 ? 483 GLU A OE1 1 
ATOM   3336 O  OE2 . GLU A 1 489 ? -0.294  -18.996 -39.373 1.00 52.56 ? 483 GLU A OE2 1 
ATOM   3337 N  N   . ARG A 1 490 ? -3.376  -19.672 -35.322 1.00 26.02 ? 484 ARG A N   1 
ATOM   3338 C  CA  . ARG A 1 490 ? -3.083  -18.430 -34.608 1.00 27.87 ? 484 ARG A CA  1 
ATOM   3339 C  C   . ARG A 1 490 ? -2.668  -18.684 -33.159 1.00 26.74 ? 484 ARG A C   1 
ATOM   3340 O  O   . ARG A 1 490 ? -2.520  -17.735 -32.382 1.00 25.10 ? 484 ARG A O   1 
ATOM   3341 C  CB  . ARG A 1 490 ? -4.302  -17.490 -34.646 1.00 29.06 ? 484 ARG A CB  1 
ATOM   3342 C  CG  . ARG A 1 490 ? -4.538  -16.745 -35.967 1.00 24.62 ? 484 ARG A CG  1 
ATOM   3343 C  CD  . ARG A 1 490 ? -3.740  -15.446 -36.038 1.00 27.66 ? 484 ARG A CD  1 
ATOM   3344 N  NE  . ARG A 1 490 ? -3.544  -14.841 -34.720 1.00 33.08 ? 484 ARG A NE  1 
ATOM   3345 C  CZ  . ARG A 1 490 ? -3.825  -13.584 -34.384 1.00 31.49 ? 484 ARG A CZ  1 
ATOM   3346 N  NH1 . ARG A 1 490 ? -4.352  -12.723 -35.249 1.00 33.84 ? 484 ARG A NH1 1 
ATOM   3347 N  NH2 . ARG A 1 490 ? -3.569  -13.176 -33.144 1.00 31.42 ? 484 ARG A NH2 1 
ATOM   3348 N  N   . GLN A 1 491 ? -2.507  -19.937 -32.768 1.00 23.07 ? 485 GLN A N   1 
ATOM   3349 C  CA  . GLN A 1 491 ? -2.037  -20.209 -31.426 1.00 28.84 ? 485 GLN A CA  1 
ATOM   3350 C  C   . GLN A 1 491 ? -0.581  -19.792 -31.301 1.00 26.12 ? 485 GLN A C   1 
ATOM   3351 O  O   . GLN A 1 491 ? 0.255   -20.124 -32.140 1.00 27.56 ? 485 GLN A O   1 
ATOM   3352 C  CB  . GLN A 1 491 ? -2.212  -21.674 -31.085 1.00 26.07 ? 485 GLN A CB  1 
ATOM   3353 C  CG  . GLN A 1 491 ? -1.912  -21.970 -29.654 1.00 26.24 ? 485 GLN A CG  1 
ATOM   3354 C  CD  . GLN A 1 491 ? -2.416  -23.325 -29.293 1.00 28.03 ? 485 GLN A CD  1 
ATOM   3355 O  OE1 . GLN A 1 491 ? -2.345  -24.249 -30.108 1.00 32.39 ? 485 GLN A OE1 1 
ATOM   3356 N  NE2 . GLN A 1 491 ? -2.955  -23.466 -28.085 1.00 25.08 ? 485 GLN A NE2 1 
ATOM   3357 N  N   . HIS A 1 492 ? -0.301  -19.026 -30.270 1.00 28.65 ? 486 HIS A N   1 
ATOM   3358 C  CA  . HIS A 1 492 ? 1.044   -18.592 -29.987 1.00 32.98 ? 486 HIS A CA  1 
ATOM   3359 C  C   . HIS A 1 492 ? 1.896   -19.769 -29.486 1.00 31.71 ? 486 HIS A C   1 
ATOM   3360 O  O   . HIS A 1 492 ? 1.375   -20.741 -28.929 1.00 29.69 ? 486 HIS A O   1 
ATOM   3361 C  CB  . HIS A 1 492 ? 0.987   -17.481 -28.946 1.00 31.15 ? 486 HIS A CB  1 
ATOM   3362 C  CG  . HIS A 1 492 ? 2.172   -16.574 -28.960 1.00 42.93 ? 486 HIS A CG  1 
ATOM   3363 N  ND1 . HIS A 1 492 ? 2.997   -16.419 -27.865 1.00 46.30 ? 486 HIS A ND1 1 
ATOM   3364 C  CD2 . HIS A 1 492 ? 2.651   -15.739 -29.912 1.00 44.92 ? 486 HIS A CD2 1 
ATOM   3365 C  CE1 . HIS A 1 492 ? 3.948   -15.549 -28.150 1.00 42.60 ? 486 HIS A CE1 1 
ATOM   3366 N  NE2 . HIS A 1 492 ? 3.762   -15.122 -29.386 1.00 46.40 ? 486 HIS A NE2 1 
ATOM   3367 N  N   . PRO A 1 493 ? 3.220   -19.701 -29.671 1.00 36.38 ? 487 PRO A N   1 
ATOM   3368 C  CA  . PRO A 1 493 ? 4.102   -20.710 -29.051 1.00 36.01 ? 487 PRO A CA  1 
ATOM   3369 C  C   . PRO A 1 493 ? 3.875   -20.922 -27.553 1.00 35.21 ? 487 PRO A C   1 
ATOM   3370 O  O   . PRO A 1 493 ? 3.967   -22.066 -27.079 1.00 34.89 ? 487 PRO A O   1 
ATOM   3371 C  CB  . PRO A 1 493 ? 5.499   -20.150 -29.333 1.00 36.74 ? 487 PRO A CB  1 
ATOM   3372 C  CG  . PRO A 1 493 ? 5.341   -19.388 -30.579 1.00 37.03 ? 487 PRO A CG  1 
ATOM   3373 C  CD  . PRO A 1 493 ? 3.978   -18.753 -30.505 1.00 37.45 ? 487 PRO A CD  1 
ATOM   3374 N  N   . ASP A 1 494 ? 3.581   -19.867 -26.786 1.00 34.60 ? 488 ASP A N   1 
ATOM   3375 C  CA  . ASP A 1 494 ? 3.323   -20.056 -25.360 1.00 32.06 ? 488 ASP A CA  1 
ATOM   3376 C  C   . ASP A 1 494 ? 1.955   -20.673 -25.091 1.00 32.26 ? 488 ASP A C   1 
ATOM   3377 O  O   . ASP A 1 494 ? 1.568   -20.811 -23.923 1.00 31.57 ? 488 ASP A O   1 
ATOM   3378 C  CB  . ASP A 1 494 ? 3.482   -18.730 -24.596 1.00 32.17 ? 488 ASP A CB  1 
ATOM   3379 C  CG  . ASP A 1 494 ? 2.412   -17.699 -24.936 1.00 35.09 ? 488 ASP A CG  1 
ATOM   3380 O  OD1 . ASP A 1 494 ? 1.454   -18.022 -25.675 1.00 40.00 ? 488 ASP A OD1 1 
ATOM   3381 O  OD2 . ASP A 1 494 ? 2.545   -16.541 -24.474 1.00 35.09 ? 488 ASP A OD2 1 
ATOM   3382 N  N   . GLY A 1 495 ? 1.216   -21.045 -26.140 1.00 29.54 ? 489 GLY A N   1 
ATOM   3383 C  CA  . GLY A 1 495 ? -0.052  -21.717 -25.978 1.00 24.04 ? 489 GLY A CA  1 
ATOM   3384 C  C   . GLY A 1 495 ? -1.256  -20.802 -25.975 1.00 25.08 ? 489 GLY A C   1 
ATOM   3385 O  O   . GLY A 1 495 ? -2.388  -21.302 -25.970 1.00 22.60 ? 489 GLY A O   1 
ATOM   3386 N  N   . GLY A 1 496 ? -1.047  -19.485 -26.004 1.00 23.15 ? 490 GLY A N   1 
ATOM   3387 C  CA  . GLY A 1 496 ? -2.109  -18.522 -25.839 1.00 24.45 ? 490 GLY A CA  1 
ATOM   3388 C  C   . GLY A 1 496 ? -2.477  -17.809 -27.125 1.00 23.22 ? 490 GLY A C   1 
ATOM   3389 O  O   . GLY A 1 496 ? -2.007  -18.127 -28.219 1.00 22.72 ? 490 GLY A O   1 
ATOM   3390 N  N   . TYR A 1 497 ? -3.324  -16.801 -26.973 1.00 19.79 ? 491 TYR A N   1 
ATOM   3391 C  CA  . TYR A 1 497 ? -3.794  -16.020 -28.105 1.00 25.92 ? 491 TYR A CA  1 
ATOM   3392 C  C   . TYR A 1 497 ? -3.636  -14.534 -27.813 1.00 22.86 ? 491 TYR A C   1 
ATOM   3393 O  O   . TYR A 1 497 ? -3.888  -14.076 -26.696 1.00 22.53 ? 491 TYR A O   1 
ATOM   3394 C  CB  . TYR A 1 497 ? -5.258  -16.372 -28.427 1.00 21.23 ? 491 TYR A CB  1 
ATOM   3395 C  CG  . TYR A 1 497 ? -5.402  -17.746 -29.050 1.00 18.43 ? 491 TYR A CG  1 
ATOM   3396 C  CD1 . TYR A 1 497 ? -5.433  -18.890 -28.256 1.00 17.35 ? 491 TYR A CD1 1 
ATOM   3397 C  CD2 . TYR A 1 497 ? -5.469  -17.903 -30.439 1.00 19.93 ? 491 TYR A CD2 1 
ATOM   3398 C  CE1 . TYR A 1 497 ? -5.539  -20.156 -28.817 1.00 20.55 ? 491 TYR A CE1 1 
ATOM   3399 C  CE2 . TYR A 1 497 ? -5.584  -19.170 -31.011 1.00 20.21 ? 491 TYR A CE2 1 
ATOM   3400 C  CZ  . TYR A 1 497 ? -5.621  -20.286 -30.197 1.00 19.94 ? 491 TYR A CZ  1 
ATOM   3401 O  OH  . TYR A 1 497 ? -5.731  -21.542 -30.742 1.00 22.30 ? 491 TYR A OH  1 
ATOM   3402 N  N   . ARG A 1 498 ? -3.193  -13.789 -28.816 1.00 24.43 ? 492 ARG A N   1 
ATOM   3403 C  CA  . ARG A 1 498 ? -3.201  -12.334 -28.775 1.00 23.85 ? 492 ARG A CA  1 
ATOM   3404 C  C   . ARG A 1 498 ? -4.274  -11.865 -29.735 1.00 25.31 ? 492 ARG A C   1 
ATOM   3405 O  O   . ARG A 1 498 ? -4.268  -12.247 -30.909 1.00 32.12 ? 492 ARG A O   1 
ATOM   3406 C  CB  . ARG A 1 498 ? -1.845  -11.753 -29.158 1.00 28.74 ? 492 ARG A CB  1 
ATOM   3407 C  CG  . ARG A 1 498 ? -0.829  -11.832 -28.050 1.00 33.57 ? 492 ARG A CG  1 
ATOM   3408 C  CD  . ARG A 1 498 ? -0.031  -13.088 -28.204 1.00 38.36 ? 492 ARG A CD  1 
ATOM   3409 N  NE  . ARG A 1 498 ? 1.011   -13.192 -27.191 1.00 44.70 ? 492 ARG A NE  1 
ATOM   3410 C  CZ  . ARG A 1 498 ? 1.151   -14.224 -26.369 1.00 45.74 ? 492 ARG A CZ  1 
ATOM   3411 N  NH1 . ARG A 1 498 ? 0.286   -15.232 -26.366 1.00 35.42 ? 492 ARG A NH1 1 
ATOM   3412 N  NH2 . ARG A 1 498 ? 2.190   -14.253 -25.535 1.00 44.46 ? 492 ARG A NH2 1 
ATOM   3413 N  N   . SER A 1 499 ? -5.238  -11.111 -29.235 1.00 20.17 ? 493 SER A N   1 
ATOM   3414 C  CA  . SER A 1 499 ? -6.306  -10.602 -30.121 1.00 21.93 ? 493 SER A CA  1 
ATOM   3415 C  C   . SER A 1 499 ? -6.603  -9.131  -29.898 1.00 20.52 ? 493 SER A C   1 
ATOM   3416 O  O   . SER A 1 499 ? -6.443  -8.654  -28.781 1.00 20.50 ? 493 SER A O   1 
ATOM   3417 C  CB  . SER A 1 499 ? -7.590  -11.402 -29.985 1.00 19.79 ? 493 SER A CB  1 
ATOM   3418 O  OG  . SER A 1 499 ? -8.618  -10.883 -30.806 1.00 25.76 ? 493 SER A OG  1 
ATOM   3419 N  N   . ARG A 1 500 ? -6.967  -8.452  -30.970 1.00 18.82 ? 494 ARG A N   1 
ATOM   3420 C  CA  . ARG A 1 500 ? -7.501  -7.095  -30.793 1.00 21.66 ? 494 ARG A CA  1 
ATOM   3421 C  C   . ARG A 1 500 ? -8.667  -7.238  -29.807 1.00 20.47 ? 494 ARG A C   1 
ATOM   3422 O  O   . ARG A 1 500 ? -9.383  -8.236  -29.866 1.00 21.71 ? 494 ARG A O   1 
ATOM   3423 C  CB  . ARG A 1 500 ? -7.975  -6.533  -32.134 1.00 23.01 ? 494 ARG A CB  1 
ATOM   3424 C  CG  . ARG A 1 500 ? -9.484  -6.408  -32.277 1.00 29.75 ? 494 ARG A CG  1 
ATOM   3425 C  CD  . ARG A 1 500 ? -9.914  -6.008  -33.674 1.00 31.71 ? 494 ARG A CD  1 
ATOM   3426 N  NE  . ARG A 1 500 ? -10.157 -4.578  -33.774 1.00 31.02 ? 494 ARG A NE  1 
ATOM   3427 C  CZ  . ARG A 1 500 ? -10.851 -3.989  -34.738 1.00 39.89 ? 494 ARG A CZ  1 
ATOM   3428 N  NH1 . ARG A 1 500 ? -11.388 -4.704  -35.711 1.00 31.69 ? 494 ARG A NH1 1 
ATOM   3429 N  NH2 . ARG A 1 500 ? -11.008 -2.678  -34.725 1.00 31.30 ? 494 ARG A NH2 1 
ATOM   3430 N  N   . PRO A 1 501 ? -8.861  -6.283  -28.888 1.00 24.79 ? 495 PRO A N   1 
ATOM   3431 C  CA  . PRO A 1 501 ? -9.963  -6.361  -27.941 1.00 18.64 ? 495 PRO A CA  1 
ATOM   3432 C  C   . PRO A 1 501 ? -11.355 -6.171  -28.567 1.00 19.56 ? 495 PRO A C   1 
ATOM   3433 O  O   . PRO A 1 501 ? -11.462 -5.581  -29.597 1.00 23.09 ? 495 PRO A O   1 
ATOM   3434 C  CB  . PRO A 1 501 ? -9.639  -5.217  -26.980 1.00 20.21 ? 495 PRO A CB  1 
ATOM   3435 C  CG  . PRO A 1 501 ? -8.888  -4.222  -27.822 1.00 19.81 ? 495 PRO A CG  1 
ATOM   3436 C  CD  . PRO A 1 501 ? -8.050  -5.079  -28.742 1.00 20.65 ? 495 PRO A CD  1 
ATOM   3437 N  N   . ASP A 1 502 ? -12.373 -6.696  -27.907 1.00 19.94 ? 496 ASP A N   1 
ATOM   3438 C  CA  . ASP A 1 502 ? -13.774 -6.553  -28.375 1.00 24.72 ? 496 ASP A CA  1 
ATOM   3439 C  C   . ASP A 1 502 ? -14.640 -5.846  -27.324 1.00 25.46 ? 496 ASP A C   1 
ATOM   3440 O  O   . ASP A 1 502 ? -15.741 -5.428  -27.682 1.00 29.90 ? 496 ASP A O   1 
ATOM   3441 C  CB  . ASP A 1 502 ? -14.365 -7.911  -28.755 1.00 22.22 ? 496 ASP A CB  1 
ATOM   3442 C  CG  . ASP A 1 502 ? -14.830 -8.734  -27.571 1.00 28.73 ? 496 ASP A CG  1 
ATOM   3443 O  OD1 . ASP A 1 502 ? -14.041 -8.907  -26.632 1.00 28.75 ? 496 ASP A OD1 1 
ATOM   3444 O  OD2 . ASP A 1 502 ? -15.976 -9.198  -27.608 1.00 33.17 ? 496 ASP A OD2 1 
ATOM   3445 N  N   . GLN A 1 503 ? -14.160 -5.689  -26.085 1.00 25.69 ? 497 GLN A N   1 
ATOM   3446 C  CA  . GLN A 1 503 ? -15.020 -5.117  -25.063 1.00 24.55 ? 497 GLN A CA  1 
ATOM   3447 C  C   . GLN A 1 503 ? -15.113 -3.612  -25.251 1.00 23.43 ? 497 GLN A C   1 
ATOM   3448 O  O   . GLN A 1 503 ? -14.123 -2.945  -25.568 1.00 22.10 ? 497 GLN A O   1 
ATOM   3449 C  CB  . GLN A 1 503 ? -14.495 -5.441  -23.664 1.00 26.29 ? 497 GLN A CB  1 
ATOM   3450 C  CG  . GLN A 1 503 ? -14.498 -6.938  -23.309 1.00 28.20 ? 497 GLN A CG  1 
ATOM   3451 C  CD  . GLN A 1 503 ? -15.874 -7.564  -23.416 1.00 30.17 ? 497 GLN A CD  1 
ATOM   3452 O  OE1 . GLN A 1 503 ? -16.868 -6.992  -22.952 1.00 33.31 ? 497 GLN A OE1 1 
ATOM   3453 N  NE2 . GLN A 1 503 ? -15.951 -8.733  -24.068 1.00 31.60 ? 497 GLN A NE2 1 
ATOM   3454 N  N   . ALA A 1 504 ? -16.314 -3.082  -25.063 1.00 25.82 ? 498 ALA A N   1 
ATOM   3455 C  CA  . ALA A 1 504 ? -16.566 -1.658  -25.193 1.00 21.64 ? 498 ALA A CA  1 
ATOM   3456 C  C   . ALA A 1 504 ? -17.147 -1.109  -23.893 1.00 23.52 ? 498 ALA A C   1 
ATOM   3457 O  O   . ALA A 1 504 ? -17.894 -1.788  -23.185 1.00 22.41 ? 498 ALA A O   1 
ATOM   3458 C  CB  . ALA A 1 504 ? -17.512 -1.378  -26.365 1.00 22.38 ? 498 ALA A CB  1 
ATOM   3459 N  N   . GLY A 1 505 ? -16.795 0.138   -23.591 1.00 25.44 ? 499 GLY A N   1 
ATOM   3460 C  CA  . GLY A 1 505 ? -17.266 0.810   -22.410 1.00 25.93 ? 499 GLY A CA  1 
ATOM   3461 C  C   . GLY A 1 505 ? -16.469 2.068   -22.150 1.00 27.81 ? 499 GLY A C   1 
ATOM   3462 O  O   . GLY A 1 505 ? -15.235 2.040   -22.101 1.00 24.95 ? 499 GLY A O   1 
ATOM   3463 N  N   . PRO A 1 506 ? -17.156 3.223   -22.088 1.00 30.16 ? 500 PRO A N   1 
ATOM   3464 C  CA  . PRO A 1 506 ? -18.538 3.464   -22.533 1.00 32.02 ? 500 PRO A CA  1 
ATOM   3465 C  C   . PRO A 1 506 ? -18.672 3.089   -24.001 1.00 27.89 ? 500 PRO A C   1 
ATOM   3466 O  O   . PRO A 1 506 ? -17.799 3.444   -24.797 1.00 23.18 ? 500 PRO A O   1 
ATOM   3467 C  CB  . PRO A 1 506 ? -18.724 4.986   -22.358 1.00 31.98 ? 500 PRO A CB  1 
ATOM   3468 C  CG  . PRO A 1 506 ? -17.619 5.420   -21.458 1.00 35.03 ? 500 PRO A CG  1 
ATOM   3469 C  CD  . PRO A 1 506 ? -16.480 4.472   -21.706 1.00 27.56 ? 500 PRO A CD  1 
ATOM   3470 N  N   . ARG A 1 507 ? -19.744 2.418   -24.389 1.00 27.01 ? 501 ARG A N   1 
ATOM   3471 C  CA  . ARG A 1 507 ? -19.919 2.062   -25.791 1.00 30.32 ? 501 ARG A CA  1 
ATOM   3472 C  C   . ARG A 1 507 ? -19.821 3.317   -26.655 1.00 28.95 ? 501 ARG A C   1 
ATOM   3473 O  O   . ARG A 1 507 ? -20.361 4.363   -26.287 1.00 27.15 ? 501 ARG A O   1 
ATOM   3474 C  CB  . ARG A 1 507 ? -21.266 1.358   -25.987 1.00 29.91 ? 501 ARG A CB  1 
ATOM   3475 C  CG  . ARG A 1 507 ? -21.254 -0.071  -25.419 1.00 32.73 ? 501 ARG A CG  1 
ATOM   3476 C  CD  . ARG A 1 507 ? -22.642 -0.649  -25.232 1.00 35.16 ? 501 ARG A CD  1 
ATOM   3477 N  NE  . ARG A 1 507 ? -23.393 0.035   -24.189 1.00 40.96 ? 501 ARG A NE  1 
ATOM   3478 C  CZ  . ARG A 1 507 ? -24.528 -0.412  -23.667 1.00 44.63 ? 501 ARG A CZ  1 
ATOM   3479 N  NH1 . ARG A 1 507 ? -25.078 -1.551  -24.071 1.00 42.85 ? 501 ARG A NH1 1 
ATOM   3480 N  NH2 . ARG A 1 507 ? -25.132 0.306   -22.725 1.00 43.27 ? 501 ARG A NH2 1 
ATOM   3481 N  N   . PRO A 1 508 ? -19.129 3.264   -27.800 1.00 30.76 ? 502 PRO A N   1 
ATOM   3482 C  CA  . PRO A 1 508 ? -18.468 2.123   -28.423 1.00 25.83 ? 502 PRO A CA  1 
ATOM   3483 C  C   . PRO A 1 508 ? -16.956 2.072   -28.190 1.00 25.39 ? 502 PRO A C   1 
ATOM   3484 O  O   . PRO A 1 508 ? -16.253 1.384   -28.937 1.00 25.94 ? 502 PRO A O   1 
ATOM   3485 C  CB  . PRO A 1 508 ? -18.789 2.350   -29.909 1.00 31.70 ? 502 PRO A CB  1 
ATOM   3486 C  CG  . PRO A 1 508 ? -18.725 3.866   -30.057 1.00 29.68 ? 502 PRO A CG  1 
ATOM   3487 C  CD  . PRO A 1 508 ? -19.061 4.447   -28.680 1.00 27.24 ? 502 PRO A CD  1 
ATOM   3488 N  N   . LEU A 1 509 ? -16.422 2.781   -27.193 1.00 27.02 ? 503 LEU A N   1 
ATOM   3489 C  CA  . LEU A 1 509 ? -14.975 2.842   -26.995 1.00 24.57 ? 503 LEU A CA  1 
ATOM   3490 C  C   . LEU A 1 509 ? -14.454 1.509   -26.492 1.00 22.82 ? 503 LEU A C   1 
ATOM   3491 O  O   . LEU A 1 509 ? -14.901 1.014   -25.452 1.00 24.32 ? 503 LEU A O   1 
ATOM   3492 C  CB  . LEU A 1 509 ? -14.596 3.941   -26.007 1.00 25.11 ? 503 LEU A CB  1 
ATOM   3493 C  CG  . LEU A 1 509 ? -15.179 5.328   -26.222 1.00 24.33 ? 503 LEU A CG  1 
ATOM   3494 C  CD1 . LEU A 1 509 ? -14.627 6.288   -25.165 1.00 23.37 ? 503 LEU A CD1 1 
ATOM   3495 C  CD2 . LEU A 1 509 ? -14.865 5.806   -27.610 1.00 24.90 ? 503 LEU A CD2 1 
ATOM   3496 N  N   . LEU A 1 510 ? -13.485 0.959   -27.220 1.00 23.42 ? 504 LEU A N   1 
ATOM   3497 C  CA  . LEU A 1 510 ? -12.852 -0.301  -26.864 1.00 20.62 ? 504 LEU A CA  1 
ATOM   3498 C  C   . LEU A 1 510 ? -11.927 -0.131  -25.677 1.00 19.60 ? 504 LEU A C   1 
ATOM   3499 O  O   . LEU A 1 510 ? -11.229 0.879   -25.548 1.00 17.77 ? 504 LEU A O   1 
ATOM   3500 C  CB  . LEU A 1 510 ? -12.033 -0.831  -28.046 1.00 22.09 ? 504 LEU A CB  1 
ATOM   3501 C  CG  . LEU A 1 510 ? -12.820 -1.410  -29.222 1.00 23.81 ? 504 LEU A CG  1 
ATOM   3502 C  CD1 . LEU A 1 510 ? -11.925 -1.528  -30.442 1.00 24.57 ? 504 LEU A CD1 1 
ATOM   3503 C  CD2 . LEU A 1 510 ? -13.346 -2.779  -28.820 1.00 23.12 ? 504 LEU A CD2 1 
ATOM   3504 N  N   . TYR A 1 511 ? -11.874 -1.159  -24.842 1.00 17.30 ? 505 TYR A N   1 
ATOM   3505 C  CA  . TYR A 1 511 ? -10.806 -1.294  -23.872 1.00 16.71 ? 505 TYR A CA  1 
ATOM   3506 C  C   . TYR A 1 511 ? -10.299 -2.729  -23.925 1.00 20.01 ? 505 TYR A C   1 
ATOM   3507 O  O   . TYR A 1 511 ? -10.964 -3.623  -24.458 1.00 18.24 ? 505 TYR A O   1 
ATOM   3508 C  CB  . TYR A 1 511 ? -11.277 -0.902  -22.467 1.00 14.53 ? 505 TYR A CB  1 
ATOM   3509 C  CG  . TYR A 1 511 ? -12.374 -1.771  -21.919 1.00 17.17 ? 505 TYR A CG  1 
ATOM   3510 C  CD1 . TYR A 1 511 ? -13.708 -1.467  -22.149 1.00 18.90 ? 505 TYR A CD1 1 
ATOM   3511 C  CD2 . TYR A 1 511 ? -12.071 -2.892  -21.165 1.00 17.07 ? 505 TYR A CD2 1 
ATOM   3512 C  CE1 . TYR A 1 511 ? -14.712 -2.262  -21.646 1.00 19.77 ? 505 TYR A CE1 1 
ATOM   3513 C  CE2 . TYR A 1 511 ? -13.059 -3.688  -20.645 1.00 19.49 ? 505 TYR A CE2 1 
ATOM   3514 C  CZ  . TYR A 1 511 ? -14.381 -3.368  -20.881 1.00 24.08 ? 505 TYR A CZ  1 
ATOM   3515 O  OH  . TYR A 1 511 ? -15.365 -4.174  -20.354 1.00 23.89 ? 505 TYR A OH  1 
ATOM   3516 N  N   . ASP A 1 512 ? -9.116  -2.945  -23.361 1.00 16.80 ? 506 ASP A N   1 
ATOM   3517 C  CA  . ASP A 1 512 ? -8.340  -4.151  -23.625 1.00 15.59 ? 506 ASP A CA  1 
ATOM   3518 C  C   . ASP A 1 512 ? -8.008  -4.918  -22.348 1.00 17.28 ? 506 ASP A C   1 
ATOM   3519 O  O   . ASP A 1 512 ? -7.094  -4.533  -21.611 1.00 18.57 ? 506 ASP A O   1 
ATOM   3520 C  CB  . ASP A 1 512 ? -7.053  -3.813  -24.362 1.00 19.03 ? 506 ASP A CB  1 
ATOM   3521 C  CG  . ASP A 1 512 ? -6.319  -5.071  -24.817 1.00 23.11 ? 506 ASP A CG  1 
ATOM   3522 O  OD1 . ASP A 1 512 ? -6.883  -6.182  -24.630 1.00 20.84 ? 506 ASP A OD1 1 
ATOM   3523 O  OD2 . ASP A 1 512 ? -5.197  -4.953  -25.347 1.00 29.66 ? 506 ASP A OD2 1 
ATOM   3524 N  N   . VAL A 1 513 ? -8.720  -6.023  -22.119 1.00 15.74 ? 507 VAL A N   1 
ATOM   3525 C  CA  . VAL A 1 513 ? -8.421  -6.982  -21.045 1.00 15.38 ? 507 VAL A CA  1 
ATOM   3526 C  C   . VAL A 1 513 ? -7.838  -8.225  -21.715 1.00 16.93 ? 507 VAL A C   1 
ATOM   3527 O  O   . VAL A 1 513 ? -8.596  -9.104  -22.141 1.00 15.24 ? 507 VAL A O   1 
ATOM   3528 C  CB  . VAL A 1 513 ? -9.677  -7.297  -20.214 1.00 16.31 ? 507 VAL A CB  1 
ATOM   3529 C  CG1 . VAL A 1 513 ? -9.459  -8.513  -19.260 1.00 13.97 ? 507 VAL A CG1 1 
ATOM   3530 C  CG2 . VAL A 1 513 ? -10.094 -6.046  -19.415 1.00 21.31 ? 507 VAL A CG2 1 
ATOM   3531 N  N   . PRO A 1 514 ? -6.510  -8.322  -21.853 1.00 17.55 ? 508 PRO A N   1 
ATOM   3532 C  CA  . PRO A 1 514 ? -5.913  -9.414  -22.663 1.00 18.26 ? 508 PRO A CA  1 
ATOM   3533 C  C   . PRO A 1 514 ? -6.254  -10.830 -22.207 1.00 19.61 ? 508 PRO A C   1 
ATOM   3534 O  O   . PRO A 1 514 ? -6.294  -11.740 -23.054 1.00 21.19 ? 508 PRO A O   1 
ATOM   3535 C  CB  . PRO A 1 514 ? -4.399  -9.158  -22.551 1.00 16.94 ? 508 PRO A CB  1 
ATOM   3536 C  CG  . PRO A 1 514 ? -4.260  -7.734  -22.013 1.00 17.88 ? 508 PRO A CG  1 
ATOM   3537 C  CD  . PRO A 1 514 ? -5.506  -7.396  -21.287 1.00 16.98 ? 508 PRO A CD  1 
ATOM   3538 N  N   . ALA A 1 515 ? -6.482  -11.065 -20.908 1.00 16.23 ? 509 ALA A N   1 
ATOM   3539 C  CA  . ALA A 1 515 ? -6.752  -12.428 -20.450 1.00 16.98 ? 509 ALA A CA  1 
ATOM   3540 C  C   . ALA A 1 515 ? -7.980  -13.040 -21.119 1.00 17.12 ? 509 ALA A C   1 
ATOM   3541 O  O   . ALA A 1 515 ? -8.117  -14.269 -21.129 1.00 21.16 ? 509 ALA A O   1 
ATOM   3542 C  CB  . ALA A 1 515 ? -6.924  -12.462 -18.917 1.00 17.85 ? 509 ALA A CB  1 
ATOM   3543 N  N   . LEU A 1 516 ? -8.882  -12.221 -21.663 1.00 15.58 ? 510 LEU A N   1 
ATOM   3544 C  CA  . LEU A 1 516 ? -10.113 -12.748 -22.256 1.00 17.06 ? 510 LEU A CA  1 
ATOM   3545 C  C   . LEU A 1 516 ? -9.870  -13.514 -23.560 1.00 17.84 ? 510 LEU A C   1 
ATOM   3546 O  O   . LEU A 1 516 ? -10.661 -14.395 -23.914 1.00 16.52 ? 510 LEU A O   1 
ATOM   3547 C  CB  . LEU A 1 516 ? -11.089 -11.602 -22.518 1.00 21.82 ? 510 LEU A CB  1 
ATOM   3548 C  CG  . LEU A 1 516 ? -11.753 -10.992 -21.279 1.00 21.16 ? 510 LEU A CG  1 
ATOM   3549 C  CD1 . LEU A 1 516 ? -12.587 -9.792  -21.701 1.00 21.59 ? 510 LEU A CD1 1 
ATOM   3550 C  CD2 . LEU A 1 516 ? -12.606 -12.048 -20.595 1.00 17.22 ? 510 LEU A CD2 1 
ATOM   3551 N  N   . ALA A 1 517 ? -8.814  -13.181 -24.303 1.00 19.05 ? 511 ALA A N   1 
ATOM   3552 C  CA  . ALA A 1 517 ? -8.571  -13.851 -25.578 1.00 19.39 ? 511 ALA A CA  1 
ATOM   3553 C  C   . ALA A 1 517 ? -8.416  -15.362 -25.387 1.00 19.54 ? 511 ALA A C   1 
ATOM   3554 O  O   . ALA A 1 517 ? -9.096  -16.160 -26.049 1.00 15.97 ? 511 ALA A O   1 
ATOM   3555 C  CB  . ALA A 1 517 ? -7.338  -13.255 -26.256 1.00 16.47 ? 511 ALA A CB  1 
ATOM   3556 N  N   . ASP A 1 518 ? -7.536  -15.776 -24.467 1.00 18.66 ? 512 ASP A N   1 
ATOM   3557 C  CA  . ASP A 1 518 ? -7.402  -17.203 -24.168 1.00 22.59 ? 512 ASP A CA  1 
ATOM   3558 C  C   . ASP A 1 518 ? -8.718  -17.792 -23.704 1.00 17.16 ? 512 ASP A C   1 
ATOM   3559 O  O   . ASP A 1 518 ? -9.069  -18.917 -24.065 1.00 18.68 ? 512 ASP A O   1 
ATOM   3560 C  CB  . ASP A 1 518 ? -6.367  -17.447 -23.067 1.00 23.44 ? 512 ASP A CB  1 
ATOM   3561 C  CG  . ASP A 1 518 ? -4.950  -17.249 -23.528 1.00 26.31 ? 512 ASP A CG  1 
ATOM   3562 O  OD1 . ASP A 1 518 ? -4.732  -16.833 -24.686 1.00 27.90 ? 512 ASP A OD1 1 
ATOM   3563 O  OD2 . ASP A 1 518 ? -4.045  -17.493 -22.693 1.00 32.06 ? 512 ASP A OD2 1 
ATOM   3564 N  N   . VAL A 1 519 ? -9.424  -17.078 -22.835 1.00 16.27 ? 513 VAL A N   1 
ATOM   3565 C  CA  . VAL A 1 519 ? -10.627 -17.643 -22.238 1.00 18.87 ? 513 VAL A CA  1 
ATOM   3566 C  C   . VAL A 1 519 ? -11.677 -17.906 -23.311 1.00 16.36 ? 513 VAL A C   1 
ATOM   3567 O  O   . VAL A 1 519 ? -12.263 -18.990 -23.377 1.00 16.91 ? 513 VAL A O   1 
ATOM   3568 C  CB  . VAL A 1 519 ? -11.156 -16.724 -21.123 1.00 16.22 ? 513 VAL A CB  1 
ATOM   3569 C  CG1 . VAL A 1 519 ? -12.570 -17.091 -20.766 1.00 15.17 ? 513 VAL A CG1 1 
ATOM   3570 C  CG2 . VAL A 1 519 ? -10.248 -16.829 -19.899 1.00 16.48 ? 513 VAL A CG2 1 
ATOM   3571 N  N   . PHE A 1 520 ? -11.925 -16.932 -24.178 1.00 16.00 ? 514 PHE A N   1 
ATOM   3572 C  CA  . PHE A 1 520 ? -13.009 -17.121 -25.141 1.00 16.09 ? 514 PHE A CA  1 
ATOM   3573 C  C   . PHE A 1 520 ? -12.641 -18.144 -26.207 1.00 15.77 ? 514 PHE A C   1 
ATOM   3574 O  O   . PHE A 1 520 ? -13.496 -18.933 -26.626 1.00 18.06 ? 514 PHE A O   1 
ATOM   3575 C  CB  . PHE A 1 520 ? -13.407 -15.783 -25.764 1.00 17.08 ? 514 PHE A CB  1 
ATOM   3576 C  CG  . PHE A 1 520 ? -14.387 -15.023 -24.920 1.00 21.16 ? 514 PHE A CG  1 
ATOM   3577 C  CD1 . PHE A 1 520 ? -15.553 -15.645 -24.472 1.00 19.31 ? 514 PHE A CD1 1 
ATOM   3578 C  CD2 . PHE A 1 520 ? -14.137 -13.723 -24.546 1.00 25.03 ? 514 PHE A CD2 1 
ATOM   3579 C  CE1 . PHE A 1 520 ? -16.451 -14.978 -23.681 1.00 24.82 ? 514 PHE A CE1 1 
ATOM   3580 C  CE2 . PHE A 1 520 ? -15.045 -13.034 -23.746 1.00 33.12 ? 514 PHE A CE2 1 
ATOM   3581 C  CZ  . PHE A 1 520 ? -16.198 -13.669 -23.309 1.00 27.45 ? 514 PHE A CZ  1 
ATOM   3582 N  N   . VAL A 1 521 ? -11.384 -18.161 -26.663 1.00 13.93 ? 515 VAL A N   1 
ATOM   3583 C  CA  . VAL A 1 521 ? -10.986 -19.197 -27.618 1.00 16.67 ? 515 VAL A CA  1 
ATOM   3584 C  C   . VAL A 1 521 ? -11.115 -20.571 -26.983 1.00 15.21 ? 515 VAL A C   1 
ATOM   3585 O  O   . VAL A 1 521 ? -11.582 -21.526 -27.621 1.00 17.10 ? 515 VAL A O   1 
ATOM   3586 C  CB  . VAL A 1 521 ? -9.558  -18.955 -28.137 1.00 13.71 ? 515 VAL A CB  1 
ATOM   3587 C  CG1 . VAL A 1 521 ? -9.057  -20.198 -28.894 1.00 14.83 ? 515 VAL A CG1 1 
ATOM   3588 C  CG2 . VAL A 1 521 ? -9.533  -17.747 -29.015 1.00 13.71 ? 515 VAL A CG2 1 
ATOM   3589 N  N   . LEU A 1 522 ? -10.705 -20.705 -25.720 1.00 16.16 ? 516 LEU A N   1 
ATOM   3590 C  CA  . LEU A 1 522 ? -10.869 -21.996 -25.057 1.00 15.71 ? 516 LEU A CA  1 
ATOM   3591 C  C   . LEU A 1 522 ? -12.336 -22.377 -24.997 1.00 19.06 ? 516 LEU A C   1 
ATOM   3592 O  O   . LEU A 1 522 ? -12.692 -23.545 -25.211 1.00 20.72 ? 516 LEU A O   1 
ATOM   3593 C  CB  . LEU A 1 522 ? -10.266 -21.978 -23.646 1.00 14.31 ? 516 LEU A CB  1 
ATOM   3594 C  CG  . LEU A 1 522 ? -10.444 -23.306 -22.886 1.00 15.10 ? 516 LEU A CG  1 
ATOM   3595 C  CD1 . LEU A 1 522 ? -9.813  -24.487 -23.651 1.00 13.96 ? 516 LEU A CD1 1 
ATOM   3596 C  CD2 . LEU A 1 522 ? -9.874  -23.226 -21.484 1.00 13.35 ? 516 LEU A CD2 1 
ATOM   3597 N  N   . LEU A 1 523 ? -13.215 -21.400 -24.738 1.00 17.48 ? 517 LEU A N   1 
ATOM   3598 C  CA  . LEU A 1 523 ? -14.644 -21.705 -24.678 1.00 17.39 ? 517 LEU A CA  1 
ATOM   3599 C  C   . LEU A 1 523 ? -15.155 -22.179 -26.037 1.00 20.84 ? 517 LEU A C   1 
ATOM   3600 O  O   . LEU A 1 523 ? -15.992 -23.086 -26.109 1.00 21.60 ? 517 LEU A O   1 
ATOM   3601 C  CB  . LEU A 1 523 ? -15.430 -20.483 -24.192 1.00 15.95 ? 517 LEU A CB  1 
ATOM   3602 C  CG  . LEU A 1 523 ? -16.963 -20.583 -24.060 1.00 22.71 ? 517 LEU A CG  1 
ATOM   3603 C  CD1 . LEU A 1 523 ? -17.376 -21.420 -22.877 1.00 18.63 ? 517 LEU A CD1 1 
ATOM   3604 C  CD2 . LEU A 1 523 ? -17.631 -19.196 -23.954 1.00 20.73 ? 517 LEU A CD2 1 
ATOM   3605 N  N   . ALA A 1 524 ? -14.670 -21.576 -27.122 1.00 17.73 ? 518 ALA A N   1 
ATOM   3606 C  CA  . ALA A 1 524 ? -15.036 -22.044 -28.454 1.00 17.01 ? 518 ALA A CA  1 
ATOM   3607 C  C   . ALA A 1 524 ? -14.506 -23.448 -28.701 1.00 17.64 ? 518 ALA A C   1 
ATOM   3608 O  O   . ALA A 1 524 ? -15.241 -24.317 -29.164 1.00 20.46 ? 518 ALA A O   1 
ATOM   3609 C  CB  . ALA A 1 524 ? -14.520 -21.074 -29.523 1.00 14.21 ? 518 ALA A CB  1 
ATOM   3610 N  N   . LEU A 1 525 ? -13.227 -23.699 -28.386 1.00 17.94 ? 519 LEU A N   1 
ATOM   3611 C  CA  . LEU A 1 525 ? -12.664 -25.024 -28.648 1.00 16.91 ? 519 LEU A CA  1 
ATOM   3612 C  C   . LEU A 1 525 ? -13.347 -26.100 -27.811 1.00 22.75 ? 519 LEU A C   1 
ATOM   3613 O  O   . LEU A 1 525 ? -13.577 -27.222 -28.292 1.00 20.98 ? 519 LEU A O   1 
ATOM   3614 C  CB  . LEU A 1 525 ? -11.160 -25.027 -28.389 1.00 17.73 ? 519 LEU A CB  1 
ATOM   3615 C  CG  . LEU A 1 525 ? -10.335 -24.096 -29.265 1.00 20.39 ? 519 LEU A CG  1 
ATOM   3616 C  CD1 . LEU A 1 525 ? -8.890  -24.159 -28.816 1.00 18.17 ? 519 LEU A CD1 1 
ATOM   3617 C  CD2 . LEU A 1 525 ? -10.481 -24.436 -30.779 1.00 17.70 ? 519 LEU A CD2 1 
ATOM   3618 N  N   . ALA A 1 526 ? -13.688 -25.779 -26.556 1.00 23.65 ? 520 ALA A N   1 
ATOM   3619 C  CA  . ALA A 1 526 ? -14.386 -26.742 -25.702 1.00 25.26 ? 520 ALA A CA  1 
ATOM   3620 C  C   . ALA A 1 526 ? -15.792 -27.027 -26.219 1.00 27.67 ? 520 ALA A C   1 
ATOM   3621 O  O   . ALA A 1 526 ? -16.216 -28.185 -26.273 1.00 29.19 ? 520 ALA A O   1 
ATOM   3622 C  CB  . ALA A 1 526 ? -14.436 -26.232 -24.259 1.00 26.90 ? 520 ALA A CB  1 
ATOM   3623 N  N   . HIS A 1 527 ? -16.529 -25.986 -26.604 1.00 23.77 ? 521 HIS A N   1 
ATOM   3624 C  CA  . HIS A 1 527 ? -17.859 -26.194 -27.170 1.00 25.87 ? 521 HIS A CA  1 
ATOM   3625 C  C   . HIS A 1 527 ? -17.806 -27.077 -28.410 1.00 26.11 ? 521 HIS A C   1 
ATOM   3626 O  O   . HIS A 1 527 ? -18.701 -27.897 -28.632 1.00 30.31 ? 521 HIS A O   1 
ATOM   3627 C  CB  . HIS A 1 527 ? -18.503 -24.849 -27.529 1.00 26.38 ? 521 HIS A CB  1 
ATOM   3628 C  CG  . HIS A 1 527 ? -19.483 -24.360 -26.515 1.00 35.78 ? 521 HIS A CG  1 
ATOM   3629 N  ND1 . HIS A 1 527 ? -20.695 -24.980 -26.293 1.00 44.23 ? 521 HIS A ND1 1 
ATOM   3630 C  CD2 . HIS A 1 527 ? -19.426 -23.316 -25.648 1.00 28.98 ? 521 HIS A CD2 1 
ATOM   3631 C  CE1 . HIS A 1 527 ? -21.339 -24.343 -25.327 1.00 38.68 ? 521 HIS A CE1 1 
ATOM   3632 N  NE2 . HIS A 1 527 ? -20.594 -23.329 -24.925 1.00 35.78 ? 521 HIS A NE2 1 
ATOM   3633 N  N   . ALA A 1 528 ? -16.789 -26.896 -29.255 1.00 23.62 ? 522 ALA A N   1 
ATOM   3634 C  CA  . ALA A 1 528 ? -16.820 -27.449 -30.603 1.00 24.45 ? 522 ALA A CA  1 
ATOM   3635 C  C   . ALA A 1 528 ? -16.197 -28.835 -30.719 1.00 26.14 ? 522 ALA A C   1 
ATOM   3636 O  O   . ALA A 1 528 ? -16.251 -29.415 -31.805 1.00 33.33 ? 522 ALA A O   1 
ATOM   3637 C  CB  . ALA A 1 528 ? -16.112 -26.507 -31.585 1.00 22.50 ? 522 ALA A CB  1 
ATOM   3638 N  N   . THR A 1 529 ? -15.612 -29.374 -29.651 1.00 30.02 ? 523 THR A N   1 
ATOM   3639 C  CA  . THR A 1 529 ? -14.943 -30.682 -29.677 1.00 29.96 ? 523 THR A CA  1 
ATOM   3640 C  C   . THR A 1 529 ? -15.573 -31.661 -28.693 1.00 29.87 ? 523 THR A C   1 
ATOM   3641 O  O   . THR A 1 529 ? -16.657 -31.412 -28.162 1.00 36.66 ? 523 THR A O   1 
ATOM   3642 C  CB  . THR A 1 529 ? -13.443 -30.578 -29.330 1.00 28.47 ? 523 THR A CB  1 
ATOM   3643 O  OG1 . THR A 1 529 ? -13.297 -30.090 -27.986 1.00 34.10 ? 523 THR A OG1 1 
ATOM   3644 C  CG2 . THR A 1 529 ? -12.725 -29.659 -30.285 1.00 23.50 ? 523 THR A CG2 1 
HETATM 3645 C  C1  . FPP B 2 .   ? -19.586 -0.033  -18.694 1.00 40.19 ? 601 FPP A C1  1 
HETATM 3646 O  O1  . FPP B 2 .   ? -19.396 1.245   -19.228 1.00 42.94 ? 601 FPP A O1  1 
HETATM 3647 C  C2  . FPP B 2 .   ? -18.303 -0.827  -18.926 1.00 32.19 ? 601 FPP A C2  1 
HETATM 3648 C  C3  . FPP B 2 .   ? -17.837 -1.614  -17.703 1.00 33.98 ? 601 FPP A C3  1 
HETATM 3649 C  C4  . FPP B 2 .   ? -17.307 -0.780  -16.533 1.00 32.21 ? 601 FPP A C4  1 
HETATM 3650 C  C5  . FPP B 2 .   ? -16.963 -2.813  -18.066 1.00 31.78 ? 601 FPP A C5  1 
HETATM 3651 C  C6  . FPP B 2 .   ? -17.836 -3.842  -18.785 1.00 36.18 ? 601 FPP A C6  1 
HETATM 3652 C  C7  . FPP B 2 .   ? -18.727 -4.526  -17.751 1.00 34.46 ? 601 FPP A C7  1 
HETATM 3653 C  C8  . FPP B 2 .   ? -20.157 -3.998  -17.741 1.00 37.49 ? 601 FPP A C8  1 
HETATM 3654 C  C10 . FPP B 2 .   ? -20.939 -4.331  -16.463 1.00 32.82 ? 601 FPP A C10 1 
HETATM 3655 C  C9  . FPP B 2 .   ? -20.904 -4.264  -19.052 1.00 39.62 ? 601 FPP A C9  1 
HETATM 3656 C  C11 . FPP B 2 .   ? -21.615 -5.620  -19.013 1.00 40.55 ? 601 FPP A C11 1 
HETATM 3657 C  C12 . FPP B 2 .   ? -21.010 -6.555  -20.067 1.00 40.26 ? 601 FPP A C12 1 
HETATM 3658 C  C13 . FPP B 2 .   ? -19.586 -7.015  -19.733 1.00 42.04 ? 601 FPP A C13 1 
HETATM 3659 C  C14 . FPP B 2 .   ? -19.492 -7.761  -18.391 1.00 30.93 ? 601 FPP A C14 1 
HETATM 3660 C  C15 . FPP B 2 .   ? -18.878 -7.744  -20.881 1.00 30.53 ? 601 FPP A C15 1 
HETATM 3661 P  PA  . FPP B 2 .   ? -20.687 2.249   -19.343 1.00 43.36 ? 601 FPP A PA  1 
HETATM 3662 O  O1A . FPP B 2 .   ? -20.285 3.645   -19.522 1.00 44.32 ? 601 FPP A O1A 1 
HETATM 3663 O  O2A . FPP B 2 .   ? -21.445 2.330   -18.101 1.00 45.79 ? 601 FPP A O2A 1 
HETATM 3664 O  O3A . FPP B 2 .   ? -21.627 1.704   -20.555 1.00 46.68 ? 601 FPP A O3A 1 
HETATM 3665 P  PB  . FPP B 2 .   ? -22.600 2.648   -21.475 1.00 40.76 ? 601 FPP A PB  1 
HETATM 3666 O  O1B . FPP B 2 .   ? -22.320 2.390   -22.887 1.00 35.33 ? 601 FPP A O1B 1 
HETATM 3667 O  O2B . FPP B 2 .   ? -22.478 4.103   -21.329 1.00 42.46 ? 601 FPP A O2B 1 
HETATM 3668 O  O3B . FPP B 2 .   ? -24.016 2.359   -21.219 1.00 41.09 ? 601 FPP A O3B 1 
HETATM 3669 MG MG  . MG  C 3 .   ? -21.499 6.216   -19.676 1.00 52.98 ? 602 MG  A MG  1 
HETATM 3670 MG MG  . MG  D 3 .   ? -18.113 4.302   -17.678 1.00 31.68 ? 603 MG  A MG  1 
HETATM 3671 O  O   . HOH E 4 .   ? -2.893  -28.050 -32.878 1.00 35.53 ? 701 HOH A O   1 
HETATM 3672 O  O   . HOH E 4 .   ? -1.984  -21.304 -10.852 1.00 26.67 ? 702 HOH A O   1 
HETATM 3673 O  O   . HOH E 4 .   ? 0.903   8.130   -5.477  1.00 35.17 ? 703 HOH A O   1 
HETATM 3674 O  O   . HOH E 4 .   ? -18.618 0.120   -4.879  1.00 32.98 ? 704 HOH A O   1 
HETATM 3675 O  O   . HOH E 4 .   ? -19.297 -8.668  -3.954  1.00 27.17 ? 705 HOH A O   1 
HETATM 3676 O  O   . HOH E 4 .   ? -22.354 -8.639  -31.157 1.00 27.90 ? 706 HOH A O   1 
HETATM 3677 O  O   . HOH E 4 .   ? -12.323 -33.891 -13.844 1.00 35.44 ? 707 HOH A O   1 
HETATM 3678 O  O   . HOH E 4 .   ? -6.348  -2.619  -14.884 1.00 25.58 ? 708 HOH A O   1 
HETATM 3679 O  O   . HOH E 4 .   ? -28.029 -25.816 -8.131  1.00 30.90 ? 709 HOH A O   1 
HETATM 3680 O  O   . HOH E 4 .   ? -9.139  7.141   -4.483  1.00 26.08 ? 710 HOH A O   1 
HETATM 3681 O  O   . HOH E 4 .   ? -9.632  -2.415  -6.631  1.00 35.45 ? 711 HOH A O   1 
HETATM 3682 O  O   . HOH E 4 .   ? -26.831 -4.688  -8.493  1.00 28.75 ? 712 HOH A O   1 
HETATM 3683 O  O   . HOH E 4 .   ? -18.415 -30.217 -26.951 1.00 41.52 ? 713 HOH A O   1 
HETATM 3684 O  O   . HOH E 4 .   ? -34.944 -11.253 -44.381 1.00 31.08 ? 714 HOH A O   1 
HETATM 3685 O  O   . HOH E 4 .   ? -4.204  -13.468 -16.074 1.00 23.71 ? 715 HOH A O   1 
HETATM 3686 O  O   . HOH E 4 .   ? -36.501 -30.214 -30.674 1.00 38.44 ? 716 HOH A O   1 
HETATM 3687 O  O   . HOH E 4 .   ? -40.694 -18.310 -32.363 1.00 29.07 ? 717 HOH A O   1 
HETATM 3688 O  O   . HOH E 4 .   ? -28.686 -4.868  -11.381 1.00 20.50 ? 718 HOH A O   1 
HETATM 3689 O  O   . HOH E 4 .   ? -2.160  -24.746 -32.556 1.00 25.38 ? 719 HOH A O   1 
HETATM 3690 O  O   . HOH E 4 .   ? -8.081  -11.568 -41.744 1.00 24.73 ? 720 HOH A O   1 
HETATM 3691 O  O   . HOH E 4 .   ? -23.220 10.568  -2.566  1.00 32.50 ? 721 HOH A O   1 
HETATM 3692 O  O   . HOH E 4 .   ? 1.835   17.635  -12.929 1.00 30.23 ? 722 HOH A O   1 
HETATM 3693 O  O   . HOH E 4 .   ? -38.874 -13.828 -20.558 1.00 35.82 ? 723 HOH A O   1 
HETATM 3694 O  O   . HOH E 4 .   ? 0.244   -24.817 -23.087 1.00 21.84 ? 724 HOH A O   1 
HETATM 3695 O  O   . HOH E 4 .   ? -19.071 24.324  -4.338  1.00 28.34 ? 725 HOH A O   1 
HETATM 3696 O  O   . HOH E 4 .   ? -26.028 -17.768 -20.631 1.00 29.02 ? 726 HOH A O   1 
HETATM 3697 O  O   . HOH E 4 .   ? -17.923 -19.294 -45.348 1.00 21.59 ? 727 HOH A O   1 
HETATM 3698 O  O   . HOH E 4 .   ? -3.126  -15.027 -31.427 1.00 28.56 ? 728 HOH A O   1 
HETATM 3699 O  O   . HOH E 4 .   ? -12.374 2.491   -29.498 1.00 23.65 ? 729 HOH A O   1 
HETATM 3700 O  O   . HOH E 4 .   ? -14.439 -2.370  -34.025 1.00 30.90 ? 730 HOH A O   1 
HETATM 3701 O  O   . HOH E 4 .   ? -6.526  19.001  -1.049  1.00 29.20 ? 731 HOH A O   1 
HETATM 3702 O  O   . HOH E 4 .   ? -15.456 23.130  -16.955 1.00 27.70 ? 732 HOH A O   1 
HETATM 3703 O  O   . HOH E 4 .   ? -11.719 -8.747  -30.889 1.00 23.30 ? 733 HOH A O   1 
HETATM 3704 O  O   . HOH E 4 .   ? -9.272  2.135   -26.717 1.00 24.91 ? 734 HOH A O   1 
HETATM 3705 O  O   . HOH E 4 .   ? -17.164 -28.146 -7.432  1.00 30.05 ? 735 HOH A O   1 
HETATM 3706 O  O   . HOH E 4 .   ? -27.519 -17.610 -24.905 1.00 27.19 ? 736 HOH A O   1 
HETATM 3707 O  O   . HOH E 4 .   ? -19.944 -10.806 -1.537  1.00 19.73 ? 737 HOH A O   1 
HETATM 3708 O  O   . HOH E 4 .   ? -5.414  -15.166 -8.687  1.00 22.03 ? 738 HOH A O   1 
HETATM 3709 O  O   . HOH E 4 .   ? -9.745  12.297  -0.049  1.00 27.03 ? 739 HOH A O   1 
HETATM 3710 O  O   . HOH E 4 .   ? -5.444  -14.219 -23.077 1.00 26.24 ? 740 HOH A O   1 
HETATM 3711 O  O   . HOH E 4 .   ? -31.521 -13.029 -5.432  1.00 27.21 ? 741 HOH A O   1 
HETATM 3712 O  O   . HOH E 4 .   ? -2.878  4.000   -6.243  1.00 27.71 ? 742 HOH A O   1 
HETATM 3713 O  O   . HOH E 4 .   ? -36.328 -14.092 -37.036 1.00 30.84 ? 743 HOH A O   1 
HETATM 3714 O  O   . HOH E 4 .   ? 2.207   -24.761 -25.582 1.00 39.00 ? 744 HOH A O   1 
HETATM 3715 O  O   . HOH E 4 .   ? -8.716  17.667  -30.226 1.00 33.59 ? 745 HOH A O   1 
HETATM 3716 O  O   . HOH E 4 .   ? -4.478  -17.842 -20.109 1.00 26.47 ? 746 HOH A O   1 
HETATM 3717 O  O   . HOH E 4 .   ? -41.638 -12.196 -25.829 1.00 35.44 ? 747 HOH A O   1 
HETATM 3718 O  O   . HOH E 4 .   ? -10.149 -20.793 -44.704 1.00 29.18 ? 748 HOH A O   1 
HETATM 3719 O  O   . HOH E 4 .   ? -21.150 -4.883  -13.099 1.00 22.26 ? 749 HOH A O   1 
HETATM 3720 O  O   . HOH E 4 .   ? -11.356 -7.693  -36.212 1.00 23.37 ? 750 HOH A O   1 
HETATM 3721 O  O   . HOH E 4 .   ? -9.030  2.297   -9.388  1.00 21.19 ? 751 HOH A O   1 
HETATM 3722 O  O   . HOH E 4 .   ? -26.995 -16.982 0.924   1.00 32.39 ? 752 HOH A O   1 
HETATM 3723 O  O   . HOH E 4 .   ? -8.858  -21.727 -42.246 1.00 25.57 ? 753 HOH A O   1 
HETATM 3724 O  O   . HOH E 4 .   ? -6.810  -8.481  -25.996 1.00 24.32 ? 754 HOH A O   1 
HETATM 3725 O  O   . HOH E 4 .   ? -6.106  -15.715 -20.103 1.00 21.17 ? 755 HOH A O   1 
HETATM 3726 O  O   . HOH E 4 .   ? -6.106  -9.181  -18.642 1.00 15.81 ? 756 HOH A O   1 
HETATM 3727 O  O   . HOH E 4 .   ? -25.569 -15.657 -6.567  1.00 18.22 ? 757 HOH A O   1 
HETATM 3728 O  O   . HOH E 4 .   ? -5.764  -13.031 -37.887 1.00 21.60 ? 758 HOH A O   1 
HETATM 3729 O  O   . HOH E 4 .   ? -14.194 24.487  -24.677 1.00 35.05 ? 759 HOH A O   1 
HETATM 3730 O  O   . HOH E 4 .   ? -3.565  22.868  -7.298  1.00 42.36 ? 760 HOH A O   1 
HETATM 3731 O  O   . HOH E 4 .   ? -7.712  -0.755  -22.583 1.00 20.23 ? 761 HOH A O   1 
HETATM 3732 O  O   . HOH E 4 .   ? -38.018 -17.687 -37.413 1.00 20.32 ? 762 HOH A O   1 
HETATM 3733 O  O   . HOH E 4 .   ? -11.189 -6.178  -23.561 1.00 23.48 ? 763 HOH A O   1 
HETATM 3734 O  O   . HOH E 4 .   ? -9.459  -9.227  -6.764  1.00 29.95 ? 764 HOH A O   1 
HETATM 3735 O  O   . HOH E 4 .   ? -6.779  15.463  0.765   1.00 27.28 ? 765 HOH A O   1 
HETATM 3736 O  O   . HOH E 4 .   ? -19.527 -25.419 -40.596 1.00 34.15 ? 766 HOH A O   1 
HETATM 3737 O  O   . HOH E 4 .   ? -11.275 20.939  -14.053 1.00 30.18 ? 767 HOH A O   1 
HETATM 3738 O  O   . HOH E 4 .   ? -22.451 -20.672 -1.930  1.00 29.86 ? 768 HOH A O   1 
HETATM 3739 O  O   . HOH E 4 .   ? -12.313 2.500   -2.751  1.00 30.39 ? 769 HOH A O   1 
HETATM 3740 O  O   . HOH E 4 .   ? -15.916 -8.443  -4.647  1.00 25.76 ? 770 HOH A O   1 
HETATM 3741 O  O   . HOH E 4 .   ? -17.715 19.592  1.581   1.00 19.80 ? 771 HOH A O   1 
HETATM 3742 O  O   . HOH E 4 .   ? -16.268 0.012   -5.291  1.00 31.54 ? 772 HOH A O   1 
HETATM 3743 O  O   . HOH E 4 .   ? -1.128  -0.905  -20.398 1.00 29.37 ? 773 HOH A O   1 
HETATM 3744 O  O   . HOH E 4 .   ? -14.630 -17.059 -46.946 1.00 35.61 ? 774 HOH A O   1 
HETATM 3745 O  O   . HOH E 4 .   ? -13.998 6.776   -6.360  1.00 21.34 ? 775 HOH A O   1 
HETATM 3746 O  O   . HOH E 4 .   ? -6.087  -19.556 -41.453 1.00 28.23 ? 776 HOH A O   1 
HETATM 3747 O  O   . HOH E 4 .   ? -24.492 -4.809  -4.268  1.00 27.39 ? 777 HOH A O   1 
HETATM 3748 O  O   . HOH E 4 .   ? -9.250  -9.470  -24.820 1.00 18.82 ? 778 HOH A O   1 
HETATM 3749 O  O   . HOH E 4 .   ? -29.901 -24.145 -6.811  1.00 33.71 ? 779 HOH A O   1 
HETATM 3750 O  O   . HOH E 4 .   ? -6.821  0.925   -11.704 1.00 24.24 ? 780 HOH A O   1 
HETATM 3751 O  O   . HOH E 4 .   ? -11.578 -8.453  -25.404 1.00 23.31 ? 781 HOH A O   1 
HETATM 3752 O  O   . HOH E 4 .   ? -20.740 -6.377  -39.960 1.00 33.42 ? 782 HOH A O   1 
HETATM 3753 O  O   . HOH E 4 .   ? -34.400 -18.921 -7.431  1.00 34.73 ? 783 HOH A O   1 
HETATM 3754 O  O   . HOH E 4 .   ? -17.957 -11.138 -24.287 1.00 30.02 ? 784 HOH A O   1 
HETATM 3755 O  O   . HOH E 4 .   ? -16.240 -22.984 -46.263 1.00 37.28 ? 785 HOH A O   1 
HETATM 3756 O  O   . HOH E 4 .   ? -25.198 23.669  1.171   1.00 33.19 ? 786 HOH A O   1 
HETATM 3757 O  O   . HOH E 4 .   ? -29.632 -1.513  -17.976 1.00 30.09 ? 787 HOH A O   1 
HETATM 3758 O  O   . HOH E 4 .   ? -0.517  -19.620 -17.857 1.00 29.54 ? 788 HOH A O   1 
HETATM 3759 O  O   . HOH E 4 .   ? -23.195 22.003  -21.977 1.00 31.45 ? 789 HOH A O   1 
HETATM 3760 O  O   . HOH E 4 .   ? -17.989 -4.517  -22.204 1.00 30.79 ? 790 HOH A O   1 
HETATM 3761 O  O   . HOH E 4 .   ? -3.027  -22.938 -11.297 1.00 28.21 ? 791 HOH A O   1 
HETATM 3762 O  O   . HOH E 4 .   ? -16.635 -11.366 -0.193  1.00 18.35 ? 792 HOH A O   1 
HETATM 3763 O  O   . HOH E 4 .   ? -11.009 -15.856 -3.606  1.00 17.16 ? 793 HOH A O   1 
HETATM 3764 O  O   . HOH E 4 .   ? -25.895 33.943  -11.514 1.00 29.12 ? 794 HOH A O   1 
HETATM 3765 O  O   . HOH E 4 .   ? -3.903  0.356   -12.212 1.00 30.45 ? 795 HOH A O   1 
HETATM 3766 O  O   . HOH E 4 .   ? -17.073 29.528  -22.063 1.00 39.32 ? 796 HOH A O   1 
HETATM 3767 O  O   . HOH E 4 .   ? -28.947 28.456  -16.476 1.00 25.51 ? 797 HOH A O   1 
HETATM 3768 O  O   . HOH E 4 .   ? -39.777 -12.552 -13.954 1.00 34.65 ? 798 HOH A O   1 
HETATM 3769 O  O   . HOH E 4 .   ? -12.430 6.055   -4.463  1.00 27.86 ? 799 HOH A O   1 
HETATM 3770 O  O   . HOH E 4 .   ? -1.626  15.463  -4.151  1.00 29.22 ? 800 HOH A O   1 
HETATM 3771 O  O   . HOH E 4 .   ? -15.369 5.803   -9.880  1.00 19.25 ? 801 HOH A O   1 
HETATM 3772 O  O   . HOH E 4 .   ? -20.092 -9.207  -7.541  1.00 24.33 ? 802 HOH A O   1 
HETATM 3773 O  O   . HOH E 4 .   ? -11.740 -24.597 -2.876  1.00 22.41 ? 803 HOH A O   1 
HETATM 3774 O  O   . HOH E 4 .   ? -26.236 -6.726  -25.336 1.00 37.01 ? 804 HOH A O   1 
HETATM 3775 O  O   . HOH E 4 .   ? -30.175 -2.087  -20.853 1.00 27.01 ? 805 HOH A O   1 
HETATM 3776 O  O   . HOH E 4 .   ? -32.608 -8.055  -9.677  1.00 28.38 ? 806 HOH A O   1 
HETATM 3777 O  O   . HOH E 4 .   ? -32.037 24.174  -18.618 1.00 31.43 ? 807 HOH A O   1 
HETATM 3778 O  O   . HOH E 4 .   ? -23.865 -6.773  -38.091 1.00 34.68 ? 808 HOH A O   1 
HETATM 3779 O  O   . HOH E 4 .   ? -18.251 24.378  -30.877 1.00 39.11 ? 809 HOH A O   1 
HETATM 3780 O  O   . HOH E 4 .   ? -3.912  -12.058 -24.638 1.00 28.96 ? 810 HOH A O   1 
HETATM 3781 O  O   . HOH E 4 .   ? -8.992  12.250  -34.655 1.00 38.59 ? 811 HOH A O   1 
HETATM 3782 O  O   . HOH E 4 .   ? -9.376  -13.754 -2.688  1.00 27.49 ? 812 HOH A O   1 
HETATM 3783 O  O   . HOH E 4 .   ? -24.793 -6.283  -35.429 1.00 31.95 ? 813 HOH A O   1 
HETATM 3784 O  O   . HOH E 4 .   ? -14.598 -30.226 -24.984 1.00 31.72 ? 814 HOH A O   1 
HETATM 3785 O  O   . HOH E 4 .   ? -8.710  -13.348 -44.880 1.00 22.15 ? 815 HOH A O   1 
HETATM 3786 O  O   . HOH E 4 .   ? -7.889  -30.783 -23.808 1.00 30.49 ? 816 HOH A O   1 
HETATM 3787 O  O   . HOH E 4 .   ? 0.363   0.874   -10.299 1.00 39.10 ? 817 HOH A O   1 
HETATM 3788 O  O   . HOH E 4 .   ? -31.551 -16.292 -0.441  1.00 35.00 ? 818 HOH A O   1 
HETATM 3789 O  O   . HOH E 4 .   ? -17.621 0.463   -13.221 1.00 24.64 ? 819 HOH A O   1 
HETATM 3790 O  O   . HOH E 4 .   ? 4.499   11.607  -9.291  1.00 37.89 ? 820 HOH A O   1 
HETATM 3791 O  O   . HOH E 4 .   ? -22.137 -7.093  -28.739 1.00 32.78 ? 821 HOH A O   1 
HETATM 3792 O  O   . HOH E 4 .   ? -19.974 -12.461 -24.038 1.00 30.21 ? 822 HOH A O   1 
HETATM 3793 O  O   . HOH E 4 .   ? -2.115  -7.544  -18.901 1.00 35.46 ? 823 HOH A O   1 
HETATM 3794 O  O   . HOH E 4 .   ? -24.042 19.281  -29.460 1.00 45.73 ? 824 HOH A O   1 
HETATM 3795 O  O   . HOH E 4 .   ? -14.084 11.034  1.330   1.00 20.61 ? 825 HOH A O   1 
HETATM 3796 O  O   . HOH E 4 .   ? -17.277 -30.309 -10.335 1.00 28.19 ? 826 HOH A O   1 
HETATM 3797 O  O   . HOH E 4 .   ? -10.681 -9.459  -4.051  1.00 24.22 ? 827 HOH A O   1 
HETATM 3798 O  O   . HOH E 4 .   ? -15.688 -10.457 -40.725 1.00 23.77 ? 828 HOH A O   1 
HETATM 3799 O  O   . HOH E 4 .   ? -27.498 -22.087 -42.056 1.00 23.68 ? 829 HOH A O   1 
HETATM 3800 O  O   . HOH E 4 .   ? -6.931  -1.622  -7.499  1.00 40.45 ? 830 HOH A O   1 
HETATM 3801 O  O   . HOH E 4 .   ? -25.272 -9.528  -34.667 1.00 31.16 ? 831 HOH A O   1 
HETATM 3802 O  O   . HOH E 4 .   ? -49.822 -20.968 -35.419 1.00 44.65 ? 832 HOH A O   1 
HETATM 3803 O  O   . HOH E 4 .   ? -23.243 33.604  -14.620 1.00 32.80 ? 833 HOH A O   1 
HETATM 3804 O  O   . HOH E 4 .   ? -1.837  -26.333 -16.014 1.00 21.77 ? 834 HOH A O   1 
HETATM 3805 O  O   . HOH E 4 .   ? -6.535  -28.012 -11.545 1.00 23.63 ? 835 HOH A O   1 
HETATM 3806 O  O   . HOH E 4 .   ? -32.469 -9.137  -6.887  1.00 32.31 ? 836 HOH A O   1 
HETATM 3807 O  O   . HOH E 4 .   ? -20.780 25.568  -8.509  1.00 32.83 ? 837 HOH A O   1 
HETATM 3808 O  O   . HOH E 4 .   ? -28.749 23.682  -4.458  1.00 26.82 ? 838 HOH A O   1 
HETATM 3809 O  O   . HOH E 4 .   ? -45.322 -20.289 -22.766 1.00 31.22 ? 839 HOH A O   1 
HETATM 3810 O  O   . HOH E 4 .   ? 1.573   -27.493 -23.008 1.00 21.20 ? 840 HOH A O   1 
HETATM 3811 O  O   . HOH E 4 .   ? -4.815  -10.292 -26.320 1.00 23.01 ? 841 HOH A O   1 
HETATM 3812 O  O   . HOH E 4 .   ? -21.916 -25.779 -38.624 1.00 29.89 ? 842 HOH A O   1 
HETATM 3813 O  O   . HOH E 4 .   ? -26.935 -5.665  -4.320  1.00 21.47 ? 843 HOH A O   1 
HETATM 3814 O  O   . HOH E 4 .   ? -6.578  3.471   -26.097 1.00 21.33 ? 844 HOH A O   1 
HETATM 3815 O  O   . HOH E 4 .   ? 4.349   3.724   -23.445 1.00 37.04 ? 845 HOH A O   1 
HETATM 3816 O  O   . HOH E 4 .   ? -29.227 -1.592  -10.739 1.00 30.93 ? 846 HOH A O   1 
HETATM 3817 O  O   . HOH E 4 .   ? 6.462   15.805  -24.399 1.00 36.18 ? 847 HOH A O   1 
HETATM 3818 O  O   . HOH E 4 .   ? -30.393 12.575  -13.004 1.00 43.16 ? 848 HOH A O   1 
HETATM 3819 O  O   . HOH E 4 .   ? 5.297   7.700   -12.033 1.00 33.31 ? 849 HOH A O   1 
HETATM 3820 O  O   . HOH E 4 .   ? -36.476 -16.676 -39.626 1.00 30.14 ? 850 HOH A O   1 
HETATM 3821 O  O   . HOH E 4 .   ? -32.038 -23.103 -8.331  1.00 35.93 ? 851 HOH A O   1 
HETATM 3822 O  O   . HOH E 4 .   ? -15.118 -2.238  -36.648 1.00 38.23 ? 852 HOH A O   1 
HETATM 3823 O  O   . HOH E 4 .   ? -7.486  -5.107  -8.529  1.00 32.70 ? 853 HOH A O   1 
HETATM 3824 O  O   . HOH E 4 .   ? -2.558  -6.637  -25.159 1.00 34.18 ? 854 HOH A O   1 
HETATM 3825 O  O   . HOH E 4 .   ? -30.348 -12.439 -3.140  1.00 31.46 ? 855 HOH A O   1 
HETATM 3826 O  O   . HOH E 4 .   ? -11.217 -11.820 -46.523 1.00 31.18 ? 856 HOH A O   1 
HETATM 3827 O  O   . HOH E 4 .   ? -19.694 8.990   -0.700  1.00 24.40 ? 857 HOH A O   1 
HETATM 3828 O  O   . HOH E 4 .   ? 1.273   -21.811 -12.797 1.00 34.01 ? 858 HOH A O   1 
HETATM 3829 O  O   . HOH E 4 .   ? -26.272 -0.564  -7.669  1.00 36.28 ? 859 HOH A O   1 
HETATM 3830 O  O   . HOH E 4 .   ? -21.785 17.554  -1.531  1.00 12.56 ? 860 HOH A O   1 
HETATM 3831 O  O   . HOH E 4 .   ? -33.402 -3.318  -11.353 1.00 33.36 ? 861 HOH A O   1 
HETATM 3832 O  O   . HOH E 4 .   ? -21.804 -29.719 -6.514  1.00 14.19 ? 862 HOH A O   1 
HETATM 3833 O  O   . HOH E 4 .   ? -7.169  -8.775  -11.765 1.00 12.49 ? 863 HOH A O   1 
HETATM 3834 O  O   . HOH E 4 .   ? -17.688 -27.272 -41.367 1.00 27.95 ? 864 HOH A O   1 
HETATM 3835 O  O   . HOH E 4 .   ? -7.086  -0.018  -24.421 1.00 32.94 ? 865 HOH A O   1 
HETATM 3836 O  O   . HOH E 4 .   ? -3.698  -1.879  -13.607 1.00 30.23 ? 866 HOH A O   1 
HETATM 3837 O  O   . HOH E 4 .   ? -8.234  3.162   -34.805 1.00 45.20 ? 867 HOH A O   1 
HETATM 3838 O  O   . HOH E 4 .   ? -23.925 31.499  -12.803 1.00 25.85 ? 868 HOH A O   1 
HETATM 3839 O  O   . HOH E 4 .   ? -17.678 -10.009 -39.531 1.00 29.66 ? 869 HOH A O   1 
HETATM 3840 O  O   . HOH E 4 .   ? -20.182 -18.721 -0.918  1.00 27.39 ? 870 HOH A O   1 
HETATM 3841 O  O   . HOH E 4 .   ? -9.832  2.167   -30.050 1.00 24.34 ? 871 HOH A O   1 
HETATM 3842 O  O   . HOH E 4 .   ? -5.686  -28.300 -18.643 1.00 21.84 ? 872 HOH A O   1 
HETATM 3843 O  O   . HOH E 4 .   ? -16.812 5.959   2.306   1.00 37.65 ? 873 HOH A O   1 
HETATM 3844 O  O   . HOH E 4 .   ? -27.536 -23.239 -24.465 1.00 35.05 ? 874 HOH A O   1 
HETATM 3845 O  O   . HOH E 4 .   ? -7.553  -11.301 -9.443  1.00 29.62 ? 875 HOH A O   1 
HETATM 3846 O  O   . HOH E 4 .   ? -13.688 -9.173  -3.156  1.00 22.23 ? 876 HOH A O   1 
HETATM 3847 O  O   . HOH E 4 .   ? -12.804 22.015  -17.145 1.00 36.04 ? 877 HOH A O   1 
HETATM 3848 O  O   . HOH E 4 .   ? -9.354  -27.815 -38.429 1.00 32.17 ? 878 HOH A O   1 
HETATM 3849 O  O   . HOH E 4 .   ? -19.023 -29.458 -24.702 1.00 39.21 ? 879 HOH A O   1 
HETATM 3850 O  O   . HOH E 4 .   ? -15.308 7.814   -8.015  1.00 18.88 ? 880 HOH A O   1 
HETATM 3851 O  O   . HOH E 4 .   ? 6.356   13.487  -8.131  1.00 30.03 ? 881 HOH A O   1 
HETATM 3852 O  O   . HOH E 4 .   ? -11.193 24.420  -16.039 1.00 38.54 ? 882 HOH A O   1 
HETATM 3853 O  O   . HOH E 4 .   ? -33.519 -11.658 -5.987  1.00 33.44 ? 883 HOH A O   1 
HETATM 3854 O  O   . HOH E 4 .   ? -3.121  -12.197 -20.695 1.00 20.97 ? 884 HOH A O   1 
HETATM 3855 O  O   . HOH E 4 .   ? -13.884 -6.346  -2.510  1.00 28.39 ? 885 HOH A O   1 
HETATM 3856 O  O   . HOH E 4 .   ? -6.005  -21.716 -41.703 1.00 34.47 ? 886 HOH A O   1 
HETATM 3857 O  O   . HOH E 4 .   ? -30.151 -24.944 0.105   1.00 41.21 ? 887 HOH A O   1 
HETATM 3858 O  O   . HOH E 4 .   ? -6.374  1.009   -8.269  1.00 29.88 ? 888 HOH A O   1 
HETATM 3859 O  O   . HOH E 4 .   ? -24.409 35.318  -19.089 1.00 34.24 ? 889 HOH A O   1 
HETATM 3860 O  O   . HOH E 4 .   ? -24.967 16.928  -28.117 1.00 29.31 ? 890 HOH A O   1 
HETATM 3861 O  O   . HOH E 4 .   ? -5.382  -29.902 -20.423 1.00 24.64 ? 891 HOH A O   1 
HETATM 3862 O  O   . HOH E 4 .   ? -18.852 -29.714 -6.132  1.00 37.34 ? 892 HOH A O   1 
HETATM 3863 O  O   . HOH E 4 .   ? -2.551  -11.532 -16.096 1.00 26.21 ? 893 HOH A O   1 
HETATM 3864 O  O   . HOH E 4 .   ? -9.802  -10.455 -44.778 1.00 29.91 ? 894 HOH A O   1 
HETATM 3865 O  O   . HOH E 4 .   ? -40.940 -12.815 -35.244 1.00 35.13 ? 895 HOH A O   1 
HETATM 3866 O  O   . HOH E 4 .   ? 1.251   -18.872 -15.737 1.00 32.66 ? 896 HOH A O   1 
HETATM 3867 O  O   . HOH E 4 .   ? -30.779 27.057  -14.436 1.00 35.76 ? 897 HOH A O   1 
HETATM 3868 O  O   . HOH E 4 .   ? -18.958 26.277  -6.677  1.00 35.82 ? 898 HOH A O   1 
HETATM 3869 O  O   . HOH E 4 .   ? -31.188 -5.412  -10.020 1.00 35.39 ? 899 HOH A O   1 
HETATM 3870 O  O   . HOH E 4 .   ? -31.222 -6.299  -2.541  1.00 36.93 ? 900 HOH A O   1 
HETATM 3871 O  O   . HOH E 4 .   ? -0.471  -25.456 -13.528 1.00 19.23 ? 901 HOH A O   1 
HETATM 3872 O  O   . HOH E 4 .   ? -3.271  -10.184 -18.461 1.00 22.32 ? 902 HOH A O   1 
HETATM 3873 O  O   . HOH E 4 .   ? -43.436 -23.339 -45.921 1.00 40.16 ? 903 HOH A O   1 
HETATM 3874 O  O   . HOH E 4 .   ? -32.290 25.965  -16.338 1.00 29.99 ? 904 HOH A O   1 
HETATM 3875 O  O   . HOH E 4 .   ? -21.900 -8.787  0.964   1.00 27.76 ? 905 HOH A O   1 
HETATM 3876 O  O   . HOH E 4 .   ? -4.031  -14.788 -18.536 1.00 20.22 ? 906 HOH A O   1 
HETATM 3877 O  O   . HOH E 4 .   ? -24.118 -23.870 -40.300 1.00 27.79 ? 907 HOH A O   1 
HETATM 3878 O  O   . HOH E 4 .   ? -7.966  -31.131 -21.059 1.00 23.72 ? 908 HOH A O   1 
HETATM 3879 O  O   . HOH E 4 .   ? -26.798 -24.017 -40.612 1.00 29.12 ? 909 HOH A O   1 
HETATM 3880 O  O   . HOH E 4 .   ? -2.031  -10.602 -13.616 1.00 30.96 ? 910 HOH A O   1 
HETATM 3881 O  O   . HOH E 4 .   ? -33.007 -7.191  -4.328  1.00 37.01 ? 911 HOH A O   1 
# 
