data_8ZFB
# 
_entry.id   8ZFB 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZFB         pdb_00008zfb 10.2210/pdb8zfb/pdb 
WWPDB D_1300047490 ?            ?                   
EMDB  EMD-60055    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Half map'        1 0 2025-02-26 1 
4 'Half map'        1 0 2025-02-26 2 
5 Image             1 0 2025-02-26 ? 
6 Mask              1 0 2025-02-26 1 
7 'Primary map'     1 0 2025-02-26 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 Mask              repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZFB 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-07 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
EMDB 'Cryo-EM structure of the receptor of xtGPR4-Gs complex in pH7.2' EMD-60055 'associated EM volume' 
EMDB 'Cryo-EM structure of the xtGPR4-Gs complex in pH7.2'             EMD-60054 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              r1767683404@163.com 
_pdbx_contact_author.name_first         Jinpeng 
_pdbx_contact_author.name_last          Sun 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3572-1580 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Rong, N.K.' 1 0000-0002-7455-8512 
'Wen, X.'    2 ?                   
'Yang, F.'   3 0000-0002-3000-2336 
'Sun, J.P.'  4 0000-0003-3572-1580 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Cell 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1097-4172 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            188 
_citation.language                  ? 
_citation.page_first                653 
_citation.page_last                 670.e24 
_citation.title                     'Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.cell.2024.12.001 
_citation.pdbx_database_id_PubMed   39753131 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wen, X.'   1  ? 
primary 'Shang, P.' 2  ? 
primary 'Chen, H.'  3  ? 
primary 'Guo, L.'   4  ? 
primary 'Rong, N.'  5  ? 
primary 'Jiang, X.' 6  ? 
primary 'Li, X.'    7  ? 
primary 'Liu, J.'   8  ? 
primary 'Yang, G.'  9  ? 
primary 'Zhang, J.' 10 ? 
primary 'Zhu, K.'   11 ? 
primary 'Meng, Q.'  12 ? 
primary 'He, X.'    13 ? 
primary 'Wang, Z.'  14 ? 
primary 'Liu, Z.'   15 ? 
primary 'Cheng, H.' 16 ? 
primary 'Zheng, Y.' 17 ? 
primary 'Zhang, B.' 18 ? 
primary 'Pang, J.'  19 ? 
primary 'Liu, Z.'   20 ? 
primary 'Xiao, P.'  21 ? 
primary 'Chen, Y.'  22 ? 
primary 'Liu, L.'   23 ? 
primary 'Luo, F.'   24 ? 
primary 'Yu, X.'    25 ? 
primary 'Yi, F.'    26 ? 
primary 'Zhang, P.' 27 ? 
primary 'Yang, F.'  28 ? 
primary 'Deng, C.'  29 ? 
primary 'Sun, J.P.' 30 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'G-protein coupled receptor 4' 
_entity.formula_weight             38083.359 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MSNFTPDACNVDSGLDSVLPPSLYALVFTLGLPANLLALWAAWLQVRKGRELGVYLLNLSLSDLLLICALPPWTDYYLRR
DVWGYGPGACRLFGFVFYTNLYVGAAFLSCVSADRYLAVAHPLRFPGARPIRSAAAVSALIWMLELAANAPPLLGEAIHR
DRYNHTFCYESYPLSGRGAALANVGRVLAGFLLPWGVMMLCYAGLLRALRGSASCEQRERRRVRRLALGLPCVALLCYGP
YHALLLLRSLVFLVGGGSVDAGGGCALEERLFPAYHASLALATLNCLADPALYCLACPGARGEVAKVVGGVVAWAMGKER
RAWGERGGNGRGCGEGEEVGMVELRGNGREFVV
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MSNFTPDACNVDSGLDSVLPPSLYALVFTLGLPANLLALWAAWLQVRKGRELGVYLLNLSLSDLLLICALPPWTDYYLRR
DVWGYGPGACRLFGFVFYTNLYVGAAFLSCVSADRYLAVAHPLRFPGARPIRSAAAVSALIWMLELAANAPPLLGEAIHR
DRYNHTFCYESYPLSGRGAALANVGRVLAGFLLPWGVMMLCYAGLLRALRGSASCEQRERRRVRRLALGLPCVALLCYGP
YHALLLLRSLVFLVGGGSVDAGGGCALEERLFPAYHASLALATLNCLADPALYCLACPGARGEVAKVVGGVVAWAMGKER
RAWGERGGNGRGCGEGEEVGMVELRGNGREFVV
;
_entity_poly.pdbx_strand_id                 R 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   ASN n 
1 4   PHE n 
1 5   THR n 
1 6   PRO n 
1 7   ASP n 
1 8   ALA n 
1 9   CYS n 
1 10  ASN n 
1 11  VAL n 
1 12  ASP n 
1 13  SER n 
1 14  GLY n 
1 15  LEU n 
1 16  ASP n 
1 17  SER n 
1 18  VAL n 
1 19  LEU n 
1 20  PRO n 
1 21  PRO n 
1 22  SER n 
1 23  LEU n 
1 24  TYR n 
1 25  ALA n 
1 26  LEU n 
1 27  VAL n 
1 28  PHE n 
1 29  THR n 
1 30  LEU n 
1 31  GLY n 
1 32  LEU n 
1 33  PRO n 
1 34  ALA n 
1 35  ASN n 
1 36  LEU n 
1 37  LEU n 
1 38  ALA n 
1 39  LEU n 
1 40  TRP n 
1 41  ALA n 
1 42  ALA n 
1 43  TRP n 
1 44  LEU n 
1 45  GLN n 
1 46  VAL n 
1 47  ARG n 
1 48  LYS n 
1 49  GLY n 
1 50  ARG n 
1 51  GLU n 
1 52  LEU n 
1 53  GLY n 
1 54  VAL n 
1 55  TYR n 
1 56  LEU n 
1 57  LEU n 
1 58  ASN n 
1 59  LEU n 
1 60  SER n 
1 61  LEU n 
1 62  SER n 
1 63  ASP n 
1 64  LEU n 
1 65  LEU n 
1 66  LEU n 
1 67  ILE n 
1 68  CYS n 
1 69  ALA n 
1 70  LEU n 
1 71  PRO n 
1 72  PRO n 
1 73  TRP n 
1 74  THR n 
1 75  ASP n 
1 76  TYR n 
1 77  TYR n 
1 78  LEU n 
1 79  ARG n 
1 80  ARG n 
1 81  ASP n 
1 82  VAL n 
1 83  TRP n 
1 84  GLY n 
1 85  TYR n 
1 86  GLY n 
1 87  PRO n 
1 88  GLY n 
1 89  ALA n 
1 90  CYS n 
1 91  ARG n 
1 92  LEU n 
1 93  PHE n 
1 94  GLY n 
1 95  PHE n 
1 96  VAL n 
1 97  PHE n 
1 98  TYR n 
1 99  THR n 
1 100 ASN n 
1 101 LEU n 
1 102 TYR n 
1 103 VAL n 
1 104 GLY n 
1 105 ALA n 
1 106 ALA n 
1 107 PHE n 
1 108 LEU n 
1 109 SER n 
1 110 CYS n 
1 111 VAL n 
1 112 SER n 
1 113 ALA n 
1 114 ASP n 
1 115 ARG n 
1 116 TYR n 
1 117 LEU n 
1 118 ALA n 
1 119 VAL n 
1 120 ALA n 
1 121 HIS n 
1 122 PRO n 
1 123 LEU n 
1 124 ARG n 
1 125 PHE n 
1 126 PRO n 
1 127 GLY n 
1 128 ALA n 
1 129 ARG n 
1 130 PRO n 
1 131 ILE n 
1 132 ARG n 
1 133 SER n 
1 134 ALA n 
1 135 ALA n 
1 136 ALA n 
1 137 VAL n 
1 138 SER n 
1 139 ALA n 
1 140 LEU n 
1 141 ILE n 
1 142 TRP n 
1 143 MET n 
1 144 LEU n 
1 145 GLU n 
1 146 LEU n 
1 147 ALA n 
1 148 ALA n 
1 149 ASN n 
1 150 ALA n 
1 151 PRO n 
1 152 PRO n 
1 153 LEU n 
1 154 LEU n 
1 155 GLY n 
1 156 GLU n 
1 157 ALA n 
1 158 ILE n 
1 159 HIS n 
1 160 ARG n 
1 161 ASP n 
1 162 ARG n 
1 163 TYR n 
1 164 ASN n 
1 165 HIS n 
1 166 THR n 
1 167 PHE n 
1 168 CYS n 
1 169 TYR n 
1 170 GLU n 
1 171 SER n 
1 172 TYR n 
1 173 PRO n 
1 174 LEU n 
1 175 SER n 
1 176 GLY n 
1 177 ARG n 
1 178 GLY n 
1 179 ALA n 
1 180 ALA n 
1 181 LEU n 
1 182 ALA n 
1 183 ASN n 
1 184 VAL n 
1 185 GLY n 
1 186 ARG n 
1 187 VAL n 
1 188 LEU n 
1 189 ALA n 
1 190 GLY n 
1 191 PHE n 
1 192 LEU n 
1 193 LEU n 
1 194 PRO n 
1 195 TRP n 
1 196 GLY n 
1 197 VAL n 
1 198 MET n 
1 199 MET n 
1 200 LEU n 
1 201 CYS n 
1 202 TYR n 
1 203 ALA n 
1 204 GLY n 
1 205 LEU n 
1 206 LEU n 
1 207 ARG n 
1 208 ALA n 
1 209 LEU n 
1 210 ARG n 
1 211 GLY n 
1 212 SER n 
1 213 ALA n 
1 214 SER n 
1 215 CYS n 
1 216 GLU n 
1 217 GLN n 
1 218 ARG n 
1 219 GLU n 
1 220 ARG n 
1 221 ARG n 
1 222 ARG n 
1 223 VAL n 
1 224 ARG n 
1 225 ARG n 
1 226 LEU n 
1 227 ALA n 
1 228 LEU n 
1 229 GLY n 
1 230 LEU n 
1 231 PRO n 
1 232 CYS n 
1 233 VAL n 
1 234 ALA n 
1 235 LEU n 
1 236 LEU n 
1 237 CYS n 
1 238 TYR n 
1 239 GLY n 
1 240 PRO n 
1 241 TYR n 
1 242 HIS n 
1 243 ALA n 
1 244 LEU n 
1 245 LEU n 
1 246 LEU n 
1 247 LEU n 
1 248 ARG n 
1 249 SER n 
1 250 LEU n 
1 251 VAL n 
1 252 PHE n 
1 253 LEU n 
1 254 VAL n 
1 255 GLY n 
1 256 GLY n 
1 257 GLY n 
1 258 SER n 
1 259 VAL n 
1 260 ASP n 
1 261 ALA n 
1 262 GLY n 
1 263 GLY n 
1 264 GLY n 
1 265 CYS n 
1 266 ALA n 
1 267 LEU n 
1 268 GLU n 
1 269 GLU n 
1 270 ARG n 
1 271 LEU n 
1 272 PHE n 
1 273 PRO n 
1 274 ALA n 
1 275 TYR n 
1 276 HIS n 
1 277 ALA n 
1 278 SER n 
1 279 LEU n 
1 280 ALA n 
1 281 LEU n 
1 282 ALA n 
1 283 THR n 
1 284 LEU n 
1 285 ASN n 
1 286 CYS n 
1 287 LEU n 
1 288 ALA n 
1 289 ASP n 
1 290 PRO n 
1 291 ALA n 
1 292 LEU n 
1 293 TYR n 
1 294 CYS n 
1 295 LEU n 
1 296 ALA n 
1 297 CYS n 
1 298 PRO n 
1 299 GLY n 
1 300 ALA n 
1 301 ARG n 
1 302 GLY n 
1 303 GLU n 
1 304 VAL n 
1 305 ALA n 
1 306 LYS n 
1 307 VAL n 
1 308 VAL n 
1 309 GLY n 
1 310 GLY n 
1 311 VAL n 
1 312 VAL n 
1 313 ALA n 
1 314 TRP n 
1 315 ALA n 
1 316 MET n 
1 317 GLY n 
1 318 LYS n 
1 319 GLU n 
1 320 ARG n 
1 321 ARG n 
1 322 ALA n 
1 323 TRP n 
1 324 GLY n 
1 325 GLU n 
1 326 ARG n 
1 327 GLY n 
1 328 GLY n 
1 329 ASN n 
1 330 GLY n 
1 331 ARG n 
1 332 GLY n 
1 333 CYS n 
1 334 GLY n 
1 335 GLU n 
1 336 GLY n 
1 337 GLU n 
1 338 GLU n 
1 339 VAL n 
1 340 GLY n 
1 341 MET n 
1 342 VAL n 
1 343 GLU n 
1 344 LEU n 
1 345 ARG n 
1 346 GLY n 
1 347 ASN n 
1 348 GLY n 
1 349 ARG n 
1 350 GLU n 
1 351 PHE n 
1 352 VAL n 
1 353 VAL n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   353 
_entity_src_gen.gene_src_common_name               'tropical clawed frog' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 gpr4 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Xenopus tropicalis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     8364 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera frugiperda' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     7108 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   R . n 
A 1 2   SER 2   2   ?   ?   ?   R . n 
A 1 3   ASN 3   3   ?   ?   ?   R . n 
A 1 4   PHE 4   4   ?   ?   ?   R . n 
A 1 5   THR 5   5   ?   ?   ?   R . n 
A 1 6   PRO 6   6   ?   ?   ?   R . n 
A 1 7   ASP 7   7   ?   ?   ?   R . n 
A 1 8   ALA 8   8   ?   ?   ?   R . n 
A 1 9   CYS 9   9   ?   ?   ?   R . n 
A 1 10  ASN 10  10  ?   ?   ?   R . n 
A 1 11  VAL 11  11  ?   ?   ?   R . n 
A 1 12  ASP 12  12  ?   ?   ?   R . n 
A 1 13  SER 13  13  ?   ?   ?   R . n 
A 1 14  GLY 14  14  ?   ?   ?   R . n 
A 1 15  LEU 15  15  15  LEU LEU R . n 
A 1 16  ASP 16  16  16  ASP ASP R . n 
A 1 17  SER 17  17  17  SER SER R . n 
A 1 18  VAL 18  18  18  VAL VAL R . n 
A 1 19  LEU 19  19  19  LEU LEU R . n 
A 1 20  PRO 20  20  20  PRO PRO R . n 
A 1 21  PRO 21  21  21  PRO PRO R . n 
A 1 22  SER 22  22  22  SER SER R . n 
A 1 23  LEU 23  23  23  LEU LEU R . n 
A 1 24  TYR 24  24  24  TYR TYR R . n 
A 1 25  ALA 25  25  25  ALA ALA R . n 
A 1 26  LEU 26  26  26  LEU LEU R . n 
A 1 27  VAL 27  27  27  VAL VAL R . n 
A 1 28  PHE 28  28  28  PHE PHE R . n 
A 1 29  THR 29  29  29  THR THR R . n 
A 1 30  LEU 30  30  30  LEU LEU R . n 
A 1 31  GLY 31  31  31  GLY GLY R . n 
A 1 32  LEU 32  32  32  LEU LEU R . n 
A 1 33  PRO 33  33  33  PRO PRO R . n 
A 1 34  ALA 34  34  34  ALA ALA R . n 
A 1 35  ASN 35  35  35  ASN ASN R . n 
A 1 36  LEU 36  36  36  LEU LEU R . n 
A 1 37  LEU 37  37  37  LEU LEU R . n 
A 1 38  ALA 38  38  38  ALA ALA R . n 
A 1 39  LEU 39  39  39  LEU LEU R . n 
A 1 40  TRP 40  40  40  TRP TRP R . n 
A 1 41  ALA 41  41  41  ALA ALA R . n 
A 1 42  ALA 42  42  42  ALA ALA R . n 
A 1 43  TRP 43  43  43  TRP TRP R . n 
A 1 44  LEU 44  44  44  LEU LEU R . n 
A 1 45  GLN 45  45  45  GLN GLN R . n 
A 1 46  VAL 46  46  46  VAL VAL R . n 
A 1 47  ARG 47  47  47  ARG ARG R . n 
A 1 48  LYS 48  48  48  LYS LYS R . n 
A 1 49  GLY 49  49  49  GLY GLY R . n 
A 1 50  ARG 50  50  50  ARG ARG R . n 
A 1 51  GLU 51  51  51  GLU GLU R . n 
A 1 52  LEU 52  52  52  LEU LEU R . n 
A 1 53  GLY 53  53  53  GLY GLY R . n 
A 1 54  VAL 54  54  54  VAL VAL R . n 
A 1 55  TYR 55  55  55  TYR TYR R . n 
A 1 56  LEU 56  56  56  LEU LEU R . n 
A 1 57  LEU 57  57  57  LEU LEU R . n 
A 1 58  ASN 58  58  58  ASN ASN R . n 
A 1 59  LEU 59  59  59  LEU LEU R . n 
A 1 60  SER 60  60  60  SER SER R . n 
A 1 61  LEU 61  61  61  LEU LEU R . n 
A 1 62  SER 62  62  62  SER SER R . n 
A 1 63  ASP 63  63  63  ASP ASP R . n 
A 1 64  LEU 64  64  64  LEU LEU R . n 
A 1 65  LEU 65  65  65  LEU LEU R . n 
A 1 66  LEU 66  66  66  LEU LEU R . n 
A 1 67  ILE 67  67  67  ILE ILE R . n 
A 1 68  CYS 68  68  68  CYS CYS R . n 
A 1 69  ALA 69  69  69  ALA ALA R . n 
A 1 70  LEU 70  70  70  LEU LEU R . n 
A 1 71  PRO 71  71  71  PRO PRO R . n 
A 1 72  PRO 72  72  72  PRO PRO R . n 
A 1 73  TRP 73  73  73  TRP TRP R . n 
A 1 74  THR 74  74  74  THR THR R . n 
A 1 75  ASP 75  75  75  ASP ASP R . n 
A 1 76  TYR 76  76  76  TYR TYR R . n 
A 1 77  TYR 77  77  77  TYR TYR R . n 
A 1 78  LEU 78  78  78  LEU LEU R . n 
A 1 79  ARG 79  79  79  ARG ARG R . n 
A 1 80  ARG 80  80  80  ARG ARG R . n 
A 1 81  ASP 81  81  81  ASP ASP R . n 
A 1 82  VAL 82  82  82  VAL VAL R . n 
A 1 83  TRP 83  83  83  TRP TRP R . n 
A 1 84  GLY 84  84  84  GLY GLY R . n 
A 1 85  TYR 85  85  85  TYR TYR R . n 
A 1 86  GLY 86  86  86  GLY GLY R . n 
A 1 87  PRO 87  87  87  PRO PRO R . n 
A 1 88  GLY 88  88  88  GLY GLY R . n 
A 1 89  ALA 89  89  89  ALA ALA R . n 
A 1 90  CYS 90  90  90  CYS CYS R . n 
A 1 91  ARG 91  91  91  ARG ARG R . n 
A 1 92  LEU 92  92  92  LEU LEU R . n 
A 1 93  PHE 93  93  93  PHE PHE R . n 
A 1 94  GLY 94  94  94  GLY GLY R . n 
A 1 95  PHE 95  95  95  PHE PHE R . n 
A 1 96  VAL 96  96  96  VAL VAL R . n 
A 1 97  PHE 97  97  97  PHE PHE R . n 
A 1 98  TYR 98  98  98  TYR TYR R . n 
A 1 99  THR 99  99  99  THR THR R . n 
A 1 100 ASN 100 100 100 ASN ASN R . n 
A 1 101 LEU 101 101 101 LEU LEU R . n 
A 1 102 TYR 102 102 102 TYR TYR R . n 
A 1 103 VAL 103 103 103 VAL VAL R . n 
A 1 104 GLY 104 104 104 GLY GLY R . n 
A 1 105 ALA 105 105 105 ALA ALA R . n 
A 1 106 ALA 106 106 106 ALA ALA R . n 
A 1 107 PHE 107 107 107 PHE PHE R . n 
A 1 108 LEU 108 108 108 LEU LEU R . n 
A 1 109 SER 109 109 109 SER SER R . n 
A 1 110 CYS 110 110 110 CYS CYS R . n 
A 1 111 VAL 111 111 111 VAL VAL R . n 
A 1 112 SER 112 112 112 SER SER R . n 
A 1 113 ALA 113 113 113 ALA ALA R . n 
A 1 114 ASP 114 114 114 ASP ASP R . n 
A 1 115 ARG 115 115 115 ARG ARG R . n 
A 1 116 TYR 116 116 116 TYR TYR R . n 
A 1 117 LEU 117 117 117 LEU LEU R . n 
A 1 118 ALA 118 118 118 ALA ALA R . n 
A 1 119 VAL 119 119 119 VAL VAL R . n 
A 1 120 ALA 120 120 120 ALA ALA R . n 
A 1 121 HIS 121 121 121 HIS HIS R . n 
A 1 122 PRO 122 122 122 PRO PRO R . n 
A 1 123 LEU 123 123 123 LEU LEU R . n 
A 1 124 ARG 124 124 124 ARG ARG R . n 
A 1 125 PHE 125 125 125 PHE PHE R . n 
A 1 126 PRO 126 126 126 PRO PRO R . n 
A 1 127 GLY 127 127 127 GLY GLY R . n 
A 1 128 ALA 128 128 128 ALA ALA R . n 
A 1 129 ARG 129 129 129 ARG ARG R . n 
A 1 130 PRO 130 130 130 PRO PRO R . n 
A 1 131 ILE 131 131 131 ILE ILE R . n 
A 1 132 ARG 132 132 132 ARG ARG R . n 
A 1 133 SER 133 133 133 SER SER R . n 
A 1 134 ALA 134 134 134 ALA ALA R . n 
A 1 135 ALA 135 135 135 ALA ALA R . n 
A 1 136 ALA 136 136 136 ALA ALA R . n 
A 1 137 VAL 137 137 137 VAL VAL R . n 
A 1 138 SER 138 138 138 SER SER R . n 
A 1 139 ALA 139 139 139 ALA ALA R . n 
A 1 140 LEU 140 140 140 LEU LEU R . n 
A 1 141 ILE 141 141 141 ILE ILE R . n 
A 1 142 TRP 142 142 142 TRP TRP R . n 
A 1 143 MET 143 143 143 MET MET R . n 
A 1 144 LEU 144 144 144 LEU LEU R . n 
A 1 145 GLU 145 145 145 GLU GLU R . n 
A 1 146 LEU 146 146 146 LEU LEU R . n 
A 1 147 ALA 147 147 147 ALA ALA R . n 
A 1 148 ALA 148 148 148 ALA ALA R . n 
A 1 149 ASN 149 149 149 ASN ASN R . n 
A 1 150 ALA 150 150 150 ALA ALA R . n 
A 1 151 PRO 151 151 151 PRO PRO R . n 
A 1 152 PRO 152 152 152 PRO PRO R . n 
A 1 153 LEU 153 153 153 LEU LEU R . n 
A 1 154 LEU 154 154 154 LEU LEU R . n 
A 1 155 GLY 155 155 155 GLY GLY R . n 
A 1 156 GLU 156 156 156 GLU GLU R . n 
A 1 157 ALA 157 157 157 ALA ALA R . n 
A 1 158 ILE 158 158 158 ILE ILE R . n 
A 1 159 HIS 159 159 159 HIS HIS R . n 
A 1 160 ARG 160 160 160 ARG ARG R . n 
A 1 161 ASP 161 161 161 ASP ASP R . n 
A 1 162 ARG 162 162 162 ARG ARG R . n 
A 1 163 TYR 163 163 163 TYR TYR R . n 
A 1 164 ASN 164 164 164 ASN ASN R . n 
A 1 165 HIS 165 165 165 HIS HIS R . n 
A 1 166 THR 166 166 166 THR THR R . n 
A 1 167 PHE 167 167 167 PHE PHE R . n 
A 1 168 CYS 168 168 168 CYS CYS R . n 
A 1 169 TYR 169 169 169 TYR TYR R . n 
A 1 170 GLU 170 170 170 GLU GLU R . n 
A 1 171 SER 171 171 171 SER SER R . n 
A 1 172 TYR 172 172 172 TYR TYR R . n 
A 1 173 PRO 173 173 173 PRO PRO R . n 
A 1 174 LEU 174 174 174 LEU LEU R . n 
A 1 175 SER 175 175 175 SER SER R . n 
A 1 176 GLY 176 176 176 GLY GLY R . n 
A 1 177 ARG 177 177 177 ARG ARG R . n 
A 1 178 GLY 178 178 178 GLY GLY R . n 
A 1 179 ALA 179 179 179 ALA ALA R . n 
A 1 180 ALA 180 180 180 ALA ALA R . n 
A 1 181 LEU 181 181 181 LEU LEU R . n 
A 1 182 ALA 182 182 182 ALA ALA R . n 
A 1 183 ASN 183 183 183 ASN ASN R . n 
A 1 184 VAL 184 184 184 VAL VAL R . n 
A 1 185 GLY 185 185 185 GLY GLY R . n 
A 1 186 ARG 186 186 186 ARG ARG R . n 
A 1 187 VAL 187 187 187 VAL VAL R . n 
A 1 188 LEU 188 188 188 LEU LEU R . n 
A 1 189 ALA 189 189 189 ALA ALA R . n 
A 1 190 GLY 190 190 190 GLY GLY R . n 
A 1 191 PHE 191 191 191 PHE PHE R . n 
A 1 192 LEU 192 192 192 LEU LEU R . n 
A 1 193 LEU 193 193 193 LEU LEU R . n 
A 1 194 PRO 194 194 194 PRO PRO R . n 
A 1 195 TRP 195 195 195 TRP TRP R . n 
A 1 196 GLY 196 196 196 GLY GLY R . n 
A 1 197 VAL 197 197 197 VAL VAL R . n 
A 1 198 MET 198 198 198 MET MET R . n 
A 1 199 MET 199 199 199 MET MET R . n 
A 1 200 LEU 200 200 200 LEU LEU R . n 
A 1 201 CYS 201 201 201 CYS CYS R . n 
A 1 202 TYR 202 202 202 TYR TYR R . n 
A 1 203 ALA 203 203 203 ALA ALA R . n 
A 1 204 GLY 204 204 204 GLY GLY R . n 
A 1 205 LEU 205 205 205 LEU LEU R . n 
A 1 206 LEU 206 206 206 LEU LEU R . n 
A 1 207 ARG 207 207 207 ARG ARG R . n 
A 1 208 ALA 208 208 208 ALA ALA R . n 
A 1 209 LEU 209 209 209 LEU LEU R . n 
A 1 210 ARG 210 210 210 ARG ARG R . n 
A 1 211 GLY 211 211 211 GLY GLY R . n 
A 1 212 SER 212 212 212 SER SER R . n 
A 1 213 ALA 213 213 213 ALA ALA R . n 
A 1 214 SER 214 214 214 SER SER R . n 
A 1 215 CYS 215 215 215 CYS CYS R . n 
A 1 216 GLU 216 216 216 GLU GLU R . n 
A 1 217 GLN 217 217 217 GLN GLN R . n 
A 1 218 ARG 218 218 218 ARG ARG R . n 
A 1 219 GLU 219 219 219 GLU GLU R . n 
A 1 220 ARG 220 220 220 ARG ARG R . n 
A 1 221 ARG 221 221 221 ARG ARG R . n 
A 1 222 ARG 222 222 222 ARG ARG R . n 
A 1 223 VAL 223 223 223 VAL VAL R . n 
A 1 224 ARG 224 224 224 ARG ARG R . n 
A 1 225 ARG 225 225 225 ARG ARG R . n 
A 1 226 LEU 226 226 226 LEU LEU R . n 
A 1 227 ALA 227 227 227 ALA ALA R . n 
A 1 228 LEU 228 228 228 LEU LEU R . n 
A 1 229 GLY 229 229 229 GLY GLY R . n 
A 1 230 LEU 230 230 230 LEU LEU R . n 
A 1 231 PRO 231 231 231 PRO PRO R . n 
A 1 232 CYS 232 232 232 CYS CYS R . n 
A 1 233 VAL 233 233 233 VAL VAL R . n 
A 1 234 ALA 234 234 234 ALA ALA R . n 
A 1 235 LEU 235 235 235 LEU LEU R . n 
A 1 236 LEU 236 236 236 LEU LEU R . n 
A 1 237 CYS 237 237 237 CYS CYS R . n 
A 1 238 TYR 238 238 238 TYR TYR R . n 
A 1 239 GLY 239 239 239 GLY GLY R . n 
A 1 240 PRO 240 240 240 PRO PRO R . n 
A 1 241 TYR 241 241 241 TYR TYR R . n 
A 1 242 HIS 242 242 242 HIS HIS R . n 
A 1 243 ALA 243 243 243 ALA ALA R . n 
A 1 244 LEU 244 244 244 LEU LEU R . n 
A 1 245 LEU 245 245 245 LEU LEU R . n 
A 1 246 LEU 246 246 246 LEU LEU R . n 
A 1 247 LEU 247 247 247 LEU LEU R . n 
A 1 248 ARG 248 248 248 ARG ARG R . n 
A 1 249 SER 249 249 249 SER SER R . n 
A 1 250 LEU 250 250 250 LEU LEU R . n 
A 1 251 VAL 251 251 251 VAL VAL R . n 
A 1 252 PHE 252 252 252 PHE PHE R . n 
A 1 253 LEU 253 253 253 LEU LEU R . n 
A 1 254 VAL 254 254 254 VAL VAL R . n 
A 1 255 GLY 255 255 ?   ?   ?   R . n 
A 1 256 GLY 256 256 ?   ?   ?   R . n 
A 1 257 GLY 257 257 ?   ?   ?   R . n 
A 1 258 SER 258 258 ?   ?   ?   R . n 
A 1 259 VAL 259 259 ?   ?   ?   R . n 
A 1 260 ASP 260 260 ?   ?   ?   R . n 
A 1 261 ALA 261 261 ?   ?   ?   R . n 
A 1 262 GLY 262 262 ?   ?   ?   R . n 
A 1 263 GLY 263 263 263 GLY GLY R . n 
A 1 264 GLY 264 264 264 GLY GLY R . n 
A 1 265 CYS 265 265 265 CYS CYS R . n 
A 1 266 ALA 266 266 266 ALA ALA R . n 
A 1 267 LEU 267 267 267 LEU LEU R . n 
A 1 268 GLU 268 268 268 GLU GLU R . n 
A 1 269 GLU 269 269 269 GLU GLU R . n 
A 1 270 ARG 270 270 270 ARG ARG R . n 
A 1 271 LEU 271 271 271 LEU LEU R . n 
A 1 272 PHE 272 272 272 PHE PHE R . n 
A 1 273 PRO 273 273 273 PRO PRO R . n 
A 1 274 ALA 274 274 274 ALA ALA R . n 
A 1 275 TYR 275 275 275 TYR TYR R . n 
A 1 276 HIS 276 276 276 HIS HIS R . n 
A 1 277 ALA 277 277 277 ALA ALA R . n 
A 1 278 SER 278 278 278 SER SER R . n 
A 1 279 LEU 279 279 279 LEU LEU R . n 
A 1 280 ALA 280 280 280 ALA ALA R . n 
A 1 281 LEU 281 281 281 LEU LEU R . n 
A 1 282 ALA 282 282 282 ALA ALA R . n 
A 1 283 THR 283 283 283 THR THR R . n 
A 1 284 LEU 284 284 284 LEU LEU R . n 
A 1 285 ASN 285 285 285 ASN ASN R . n 
A 1 286 CYS 286 286 286 CYS CYS R . n 
A 1 287 LEU 287 287 287 LEU LEU R . n 
A 1 288 ALA 288 288 288 ALA ALA R . n 
A 1 289 ASP 289 289 289 ASP ASP R . n 
A 1 290 PRO 290 290 290 PRO PRO R . n 
A 1 291 ALA 291 291 291 ALA ALA R . n 
A 1 292 LEU 292 292 292 LEU LEU R . n 
A 1 293 TYR 293 293 293 TYR TYR R . n 
A 1 294 CYS 294 294 294 CYS CYS R . n 
A 1 295 LEU 295 295 295 LEU LEU R . n 
A 1 296 ALA 296 296 296 ALA ALA R . n 
A 1 297 CYS 297 297 297 CYS CYS R . n 
A 1 298 PRO 298 298 298 PRO PRO R . n 
A 1 299 GLY 299 299 299 GLY GLY R . n 
A 1 300 ALA 300 300 300 ALA ALA R . n 
A 1 301 ARG 301 301 301 ARG ARG R . n 
A 1 302 GLY 302 302 302 GLY GLY R . n 
A 1 303 GLU 303 303 303 GLU GLU R . n 
A 1 304 VAL 304 304 304 VAL VAL R . n 
A 1 305 ALA 305 305 305 ALA ALA R . n 
A 1 306 LYS 306 306 306 LYS LYS R . n 
A 1 307 VAL 307 307 307 VAL VAL R . n 
A 1 308 VAL 308 308 308 VAL VAL R . n 
A 1 309 GLY 309 309 ?   ?   ?   R . n 
A 1 310 GLY 310 310 ?   ?   ?   R . n 
A 1 311 VAL 311 311 ?   ?   ?   R . n 
A 1 312 VAL 312 312 ?   ?   ?   R . n 
A 1 313 ALA 313 313 ?   ?   ?   R . n 
A 1 314 TRP 314 314 ?   ?   ?   R . n 
A 1 315 ALA 315 315 ?   ?   ?   R . n 
A 1 316 MET 316 316 ?   ?   ?   R . n 
A 1 317 GLY 317 317 ?   ?   ?   R . n 
A 1 318 LYS 318 318 ?   ?   ?   R . n 
A 1 319 GLU 319 319 ?   ?   ?   R . n 
A 1 320 ARG 320 320 ?   ?   ?   R . n 
A 1 321 ARG 321 321 ?   ?   ?   R . n 
A 1 322 ALA 322 322 ?   ?   ?   R . n 
A 1 323 TRP 323 323 ?   ?   ?   R . n 
A 1 324 GLY 324 324 ?   ?   ?   R . n 
A 1 325 GLU 325 325 ?   ?   ?   R . n 
A 1 326 ARG 326 326 ?   ?   ?   R . n 
A 1 327 GLY 327 327 ?   ?   ?   R . n 
A 1 328 GLY 328 328 ?   ?   ?   R . n 
A 1 329 ASN 329 329 ?   ?   ?   R . n 
A 1 330 GLY 330 330 ?   ?   ?   R . n 
A 1 331 ARG 331 331 ?   ?   ?   R . n 
A 1 332 GLY 332 332 ?   ?   ?   R . n 
A 1 333 CYS 333 333 ?   ?   ?   R . n 
A 1 334 GLY 334 334 ?   ?   ?   R . n 
A 1 335 GLU 335 335 ?   ?   ?   R . n 
A 1 336 GLY 336 336 ?   ?   ?   R . n 
A 1 337 GLU 337 337 ?   ?   ?   R . n 
A 1 338 GLU 338 338 ?   ?   ?   R . n 
A 1 339 VAL 339 339 ?   ?   ?   R . n 
A 1 340 GLY 340 340 ?   ?   ?   R . n 
A 1 341 MET 341 341 ?   ?   ?   R . n 
A 1 342 VAL 342 342 ?   ?   ?   R . n 
A 1 343 GLU 343 343 ?   ?   ?   R . n 
A 1 344 LEU 344 344 ?   ?   ?   R . n 
A 1 345 ARG 345 345 ?   ?   ?   R . n 
A 1 346 GLY 346 346 ?   ?   ?   R . n 
A 1 347 ASN 347 347 ?   ?   ?   R . n 
A 1 348 GLY 348 348 ?   ?   ?   R . n 
A 1 349 ARG 349 349 ?   ?   ?   R . n 
A 1 350 GLU 350 350 ?   ?   ?   R . n 
A 1 351 PHE 351 351 ?   ?   ?   R . n 
A 1 352 VAL 352 352 ?   ?   ?   R . n 
A 1 353 VAL 353 353 ?   ?   ?   R . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 R LEU 15  ? CG  ? A LEU 15  CG  
2   1 Y 1 R LEU 15  ? CD1 ? A LEU 15  CD1 
3   1 Y 1 R LEU 15  ? CD2 ? A LEU 15  CD2 
4   1 Y 1 R LEU 23  ? CG  ? A LEU 23  CG  
5   1 Y 1 R LEU 23  ? CD1 ? A LEU 23  CD1 
6   1 Y 1 R LEU 23  ? CD2 ? A LEU 23  CD2 
7   1 Y 1 R ASP 63  ? CG  ? A ASP 63  CG  
8   1 Y 1 R ASP 63  ? OD1 ? A ASP 63  OD1 
9   1 Y 1 R ASP 63  ? OD2 ? A ASP 63  OD2 
10  1 Y 1 R ILE 67  ? CG1 ? A ILE 67  CG1 
11  1 Y 1 R ILE 67  ? CG2 ? A ILE 67  CG2 
12  1 Y 1 R ILE 67  ? CD1 ? A ILE 67  CD1 
13  1 Y 1 R LEU 70  ? CG  ? A LEU 70  CG  
14  1 Y 1 R LEU 70  ? CD1 ? A LEU 70  CD1 
15  1 Y 1 R LEU 70  ? CD2 ? A LEU 70  CD2 
16  1 Y 1 R TYR 85  ? CG  ? A TYR 85  CG  
17  1 Y 1 R TYR 85  ? CD1 ? A TYR 85  CD1 
18  1 Y 1 R TYR 85  ? CD2 ? A TYR 85  CD2 
19  1 Y 1 R TYR 85  ? CE1 ? A TYR 85  CE1 
20  1 Y 1 R TYR 85  ? CE2 ? A TYR 85  CE2 
21  1 Y 1 R TYR 85  ? CZ  ? A TYR 85  CZ  
22  1 Y 1 R TYR 85  ? OH  ? A TYR 85  OH  
23  1 Y 1 R ARG 91  ? CG  ? A ARG 91  CG  
24  1 Y 1 R ARG 91  ? CD  ? A ARG 91  CD  
25  1 Y 1 R ARG 91  ? NE  ? A ARG 91  NE  
26  1 Y 1 R ARG 91  ? CZ  ? A ARG 91  CZ  
27  1 Y 1 R ARG 91  ? NH1 ? A ARG 91  NH1 
28  1 Y 1 R ARG 91  ? NH2 ? A ARG 91  NH2 
29  1 Y 1 R MET 143 ? CG  ? A MET 143 CG  
30  1 Y 1 R MET 143 ? SD  ? A MET 143 SD  
31  1 Y 1 R MET 143 ? CE  ? A MET 143 CE  
32  1 Y 1 R GLU 145 ? CG  ? A GLU 145 CG  
33  1 Y 1 R GLU 145 ? CD  ? A GLU 145 CD  
34  1 Y 1 R GLU 145 ? OE1 ? A GLU 145 OE1 
35  1 Y 1 R GLU 145 ? OE2 ? A GLU 145 OE2 
36  1 Y 1 R PRO 152 ? CG  ? A PRO 152 CG  
37  1 Y 1 R PRO 152 ? CD  ? A PRO 152 CD  
38  1 Y 1 R LEU 153 ? CG  ? A LEU 153 CG  
39  1 Y 1 R LEU 153 ? CD1 ? A LEU 153 CD1 
40  1 Y 1 R LEU 153 ? CD2 ? A LEU 153 CD2 
41  1 Y 1 R LEU 154 ? CG  ? A LEU 154 CG  
42  1 Y 1 R LEU 154 ? CD1 ? A LEU 154 CD1 
43  1 Y 1 R LEU 154 ? CD2 ? A LEU 154 CD2 
44  1 Y 1 R GLU 156 ? CG  ? A GLU 156 CG  
45  1 Y 1 R GLU 156 ? CD  ? A GLU 156 CD  
46  1 Y 1 R GLU 156 ? OE1 ? A GLU 156 OE1 
47  1 Y 1 R GLU 156 ? OE2 ? A GLU 156 OE2 
48  1 Y 1 R ARG 160 ? CG  ? A ARG 160 CG  
49  1 Y 1 R ARG 160 ? CD  ? A ARG 160 CD  
50  1 Y 1 R ARG 160 ? NE  ? A ARG 160 NE  
51  1 Y 1 R ARG 160 ? CZ  ? A ARG 160 CZ  
52  1 Y 1 R ARG 160 ? NH1 ? A ARG 160 NH1 
53  1 Y 1 R ARG 160 ? NH2 ? A ARG 160 NH2 
54  1 Y 1 R ARG 162 ? CG  ? A ARG 162 CG  
55  1 Y 1 R ARG 162 ? CD  ? A ARG 162 CD  
56  1 Y 1 R ARG 162 ? NE  ? A ARG 162 NE  
57  1 Y 1 R ARG 162 ? CZ  ? A ARG 162 CZ  
58  1 Y 1 R ARG 162 ? NH1 ? A ARG 162 NH1 
59  1 Y 1 R ARG 162 ? NH2 ? A ARG 162 NH2 
60  1 Y 1 R TYR 163 ? CG  ? A TYR 163 CG  
61  1 Y 1 R TYR 163 ? CD1 ? A TYR 163 CD1 
62  1 Y 1 R TYR 163 ? CD2 ? A TYR 163 CD2 
63  1 Y 1 R TYR 163 ? CE1 ? A TYR 163 CE1 
64  1 Y 1 R TYR 163 ? CE2 ? A TYR 163 CE2 
65  1 Y 1 R TYR 163 ? CZ  ? A TYR 163 CZ  
66  1 Y 1 R TYR 163 ? OH  ? A TYR 163 OH  
67  1 Y 1 R ASN 164 ? CG  ? A ASN 164 CG  
68  1 Y 1 R ASN 164 ? OD1 ? A ASN 164 OD1 
69  1 Y 1 R ASN 164 ? ND2 ? A ASN 164 ND2 
70  1 Y 1 R PHE 167 ? CG  ? A PHE 167 CG  
71  1 Y 1 R PHE 167 ? CD1 ? A PHE 167 CD1 
72  1 Y 1 R PHE 167 ? CD2 ? A PHE 167 CD2 
73  1 Y 1 R PHE 167 ? CE1 ? A PHE 167 CE1 
74  1 Y 1 R PHE 167 ? CE2 ? A PHE 167 CE2 
75  1 Y 1 R PHE 167 ? CZ  ? A PHE 167 CZ  
76  1 Y 1 R SER 171 ? OG  ? A SER 171 OG  
77  1 Y 1 R ARG 177 ? CG  ? A ARG 177 CG  
78  1 Y 1 R ARG 177 ? CD  ? A ARG 177 CD  
79  1 Y 1 R ARG 177 ? NE  ? A ARG 177 NE  
80  1 Y 1 R ARG 177 ? CZ  ? A ARG 177 CZ  
81  1 Y 1 R ARG 177 ? NH1 ? A ARG 177 NH1 
82  1 Y 1 R ARG 177 ? NH2 ? A ARG 177 NH2 
83  1 Y 1 R ARG 186 ? CG  ? A ARG 186 CG  
84  1 Y 1 R ARG 186 ? CD  ? A ARG 186 CD  
85  1 Y 1 R ARG 186 ? NE  ? A ARG 186 NE  
86  1 Y 1 R ARG 186 ? CZ  ? A ARG 186 CZ  
87  1 Y 1 R ARG 186 ? NH1 ? A ARG 186 NH1 
88  1 Y 1 R ARG 186 ? NH2 ? A ARG 186 NH2 
89  1 Y 1 R VAL 187 ? CG1 ? A VAL 187 CG1 
90  1 Y 1 R VAL 187 ? CG2 ? A VAL 187 CG2 
91  1 Y 1 R ARG 222 ? CG  ? A ARG 222 CG  
92  1 Y 1 R ARG 222 ? CD  ? A ARG 222 CD  
93  1 Y 1 R ARG 222 ? NE  ? A ARG 222 NE  
94  1 Y 1 R ARG 222 ? CZ  ? A ARG 222 CZ  
95  1 Y 1 R ARG 222 ? NH1 ? A ARG 222 NH1 
96  1 Y 1 R ARG 222 ? NH2 ? A ARG 222 NH2 
97  1 Y 1 R VAL 223 ? CG1 ? A VAL 223 CG1 
98  1 Y 1 R VAL 223 ? CG2 ? A VAL 223 CG2 
99  1 Y 1 R LEU 250 ? CG  ? A LEU 250 CG  
100 1 Y 1 R LEU 250 ? CD1 ? A LEU 250 CD1 
101 1 Y 1 R LEU 250 ? CD2 ? A LEU 250 CD2 
102 1 Y 1 R LEU 271 ? CG  ? A LEU 271 CG  
103 1 Y 1 R LEU 271 ? CD1 ? A LEU 271 CD1 
104 1 Y 1 R LEU 271 ? CD2 ? A LEU 271 CD2 
105 1 Y 1 R LEU 295 ? CG  ? A LEU 295 CG  
106 1 Y 1 R LEU 295 ? CD1 ? A LEU 295 CD1 
107 1 Y 1 R LEU 295 ? CD2 ? A LEU 295 CD2 
108 1 Y 1 R ARG 301 ? CG  ? A ARG 301 CG  
109 1 Y 1 R ARG 301 ? CD  ? A ARG 301 CD  
110 1 Y 1 R ARG 301 ? NE  ? A ARG 301 NE  
111 1 Y 1 R ARG 301 ? CZ  ? A ARG 301 CZ  
112 1 Y 1 R ARG 301 ? NH1 ? A ARG 301 NH1 
113 1 Y 1 R ARG 301 ? NH2 ? A ARG 301 NH2 
114 1 Y 1 R VAL 304 ? CG1 ? A VAL 304 CG1 
115 1 Y 1 R VAL 304 ? CG2 ? A VAL 304 CG2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZFB 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZFB 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZFB 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8ZFB 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 2147 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.719 ? 2940 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 4.566 ? 315  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.042 ? 339  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.007 ? 373  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8ZFB 
_struct.title                        'Cryo-EM structure of the receptor of xtGPR4-Gs complex in pH7.2' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZFB 
_struct_keywords.text            'pH7.2, xtGPR4, receptor, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A6I8PUB9_XENTR 
_struct_ref.pdbx_db_accession          A0A6I8PUB9 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MSNFTPDACNVDSGLDSVLPPSLYALVFTLGLPANLLALWAAWLQVRKGRELGVYLLNLSLSDLLLICALPPWTDYYLRR
DVWGYGPGACRLFGFVFYTNLYVGAAFLSCVSADRYLAVAHPLRFPGARPIRSAAAVSALIWMLELAANAPPLLGEAIHR
DRYNHTFCYESYPLSGRGAALANVGRVLAGFLLPWGVMMLCYAGLLRALRGSASCEQRERRRVRRLALGLPCVALLCYGP
YHALLLLRSLVFLVGGGSVDAGGGCALEERLFPAYHASLALATLNCLADPALYCLACPGARGEVAKVVGGVVAWAMGKER
RAWGERGGNGRGCGEGEEVGMVELRGNGREFVV
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8ZFB 
_struct_ref_seq.pdbx_strand_id                R 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 353 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A6I8PUB9 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  353 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       353 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 18  ? ARG A 47  ? VAL R 18  ARG R 47  1 ? 30 
HELX_P HELX_P2  AA2 ARG A 50  ? ARG A 79  ? ARG R 50  ARG R 79  1 ? 30 
HELX_P HELX_P3  AA3 ALA A 89  ? HIS A 121 ? ALA R 89  HIS R 121 1 ? 33 
HELX_P HELX_P4  AA4 ARG A 129 ? ALA A 150 ? ARG R 129 ALA R 150 1 ? 22 
HELX_P HELX_P5  AA5 ALA A 180 ? PHE A 191 ? ALA R 180 PHE R 191 1 ? 12 
HELX_P HELX_P6  AA6 PHE A 191 ? LEU A 209 ? PHE R 191 LEU R 209 1 ? 19 
HELX_P HELX_P7  AA7 ARG A 210 ? SER A 212 ? ARG R 210 SER R 212 5 ? 3  
HELX_P HELX_P8  AA8 GLU A 216 ? LEU A 228 ? GLU R 216 LEU R 228 1 ? 13 
HELX_P HELX_P9  AA9 GLY A 229 ? GLY A 239 ? GLY R 229 GLY R 239 1 ? 11 
HELX_P HELX_P10 AB1 GLY A 239 ? VAL A 254 ? GLY R 239 VAL R 254 1 ? 16 
HELX_P HELX_P11 AB2 GLY A 264 ? THR A 283 ? GLY R 264 THR R 283 1 ? 20 
HELX_P HELX_P12 AB3 LEU A 284 ? CYS A 294 ? LEU R 284 CYS R 294 1 ? 11 
HELX_P HELX_P13 AB4 CYS A 297 ? VAL A 308 ? CYS R 297 VAL R 308 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            90 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            168 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            R 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             90 
_struct_conn.ptnr2_auth_asym_id            R 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             168 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.027 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       90 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      168 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       R 
_pdbx_modification_feature.auth_seq_id                        90 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      R 
_pdbx_modification_feature.modified_residue_auth_seq_id       168 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 125 A . ? PHE 125 R PRO 126 A ? PRO 126 R 1 -1.24 
2 TYR 172 A . ? TYR 172 R PRO 173 A ? PRO 173 R 1 -4.38 
# 
_pdbx_entry_details.entry_id                   8ZFB 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             R 
_pdbx_validate_rmsd_angle.auth_comp_id_1             TYR 
_pdbx_validate_rmsd_angle.auth_seq_id_1              169 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_2             R 
_pdbx_validate_rmsd_angle.auth_comp_id_2             TYR 
_pdbx_validate_rmsd_angle.auth_seq_id_2              169 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             C 
_pdbx_validate_rmsd_angle.auth_asym_id_3             R 
_pdbx_validate_rmsd_angle.auth_comp_id_3             TYR 
_pdbx_validate_rmsd_angle.auth_seq_id_3              169 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                95.64 
_pdbx_validate_rmsd_angle.angle_target_value         110.40 
_pdbx_validate_rmsd_angle.angle_deviation            -14.76 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.00 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP R 81  ? ? 82.37   -10.53 
2 1 ARG R 129 ? ? 37.17   73.49  
3 1 ARG R 162 ? ? -103.16 -63.59 
4 1 TYR R 163 ? ? -166.42 115.94 
5 1 TYR R 169 ? ? 45.88   19.93  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8ZFB 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8ZFB 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.78 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               167112 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.2 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Cryo-EM structure of the receptor of xtGPR4-Gs complex in pH7.2' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8ZFB 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            DIFFRACTION 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8ZFB 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8ZFB 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 R MET 1   ? A MET 1   
2  1 Y 1 R SER 2   ? A SER 2   
3  1 Y 1 R ASN 3   ? A ASN 3   
4  1 Y 1 R PHE 4   ? A PHE 4   
5  1 Y 1 R THR 5   ? A THR 5   
6  1 Y 1 R PRO 6   ? A PRO 6   
7  1 Y 1 R ASP 7   ? A ASP 7   
8  1 Y 1 R ALA 8   ? A ALA 8   
9  1 Y 1 R CYS 9   ? A CYS 9   
10 1 Y 1 R ASN 10  ? A ASN 10  
11 1 Y 1 R VAL 11  ? A VAL 11  
12 1 Y 1 R ASP 12  ? A ASP 12  
13 1 Y 1 R SER 13  ? A SER 13  
14 1 Y 1 R GLY 14  ? A GLY 14  
15 1 Y 1 R GLY 255 ? A GLY 255 
16 1 Y 1 R GLY 256 ? A GLY 256 
17 1 Y 1 R GLY 257 ? A GLY 257 
18 1 Y 1 R SER 258 ? A SER 258 
19 1 Y 1 R VAL 259 ? A VAL 259 
20 1 Y 1 R ASP 260 ? A ASP 260 
21 1 Y 1 R ALA 261 ? A ALA 261 
22 1 Y 1 R GLY 262 ? A GLY 262 
23 1 Y 1 R GLY 309 ? A GLY 309 
24 1 Y 1 R GLY 310 ? A GLY 310 
25 1 Y 1 R VAL 311 ? A VAL 311 
26 1 Y 1 R VAL 312 ? A VAL 312 
27 1 Y 1 R ALA 313 ? A ALA 313 
28 1 Y 1 R TRP 314 ? A TRP 314 
29 1 Y 1 R ALA 315 ? A ALA 315 
30 1 Y 1 R MET 316 ? A MET 316 
31 1 Y 1 R GLY 317 ? A GLY 317 
32 1 Y 1 R LYS 318 ? A LYS 318 
33 1 Y 1 R GLU 319 ? A GLU 319 
34 1 Y 1 R ARG 320 ? A ARG 320 
35 1 Y 1 R ARG 321 ? A ARG 321 
36 1 Y 1 R ALA 322 ? A ALA 322 
37 1 Y 1 R TRP 323 ? A TRP 323 
38 1 Y 1 R GLY 324 ? A GLY 324 
39 1 Y 1 R GLU 325 ? A GLU 325 
40 1 Y 1 R ARG 326 ? A ARG 326 
41 1 Y 1 R GLY 327 ? A GLY 327 
42 1 Y 1 R GLY 328 ? A GLY 328 
43 1 Y 1 R ASN 329 ? A ASN 329 
44 1 Y 1 R GLY 330 ? A GLY 330 
45 1 Y 1 R ARG 331 ? A ARG 331 
46 1 Y 1 R GLY 332 ? A GLY 332 
47 1 Y 1 R CYS 333 ? A CYS 333 
48 1 Y 1 R GLY 334 ? A GLY 334 
49 1 Y 1 R GLU 335 ? A GLU 335 
50 1 Y 1 R GLY 336 ? A GLY 336 
51 1 Y 1 R GLU 337 ? A GLU 337 
52 1 Y 1 R GLU 338 ? A GLU 338 
53 1 Y 1 R VAL 339 ? A VAL 339 
54 1 Y 1 R GLY 340 ? A GLY 340 
55 1 Y 1 R MET 341 ? A MET 341 
56 1 Y 1 R VAL 342 ? A VAL 342 
57 1 Y 1 R GLU 343 ? A GLU 343 
58 1 Y 1 R LEU 344 ? A LEU 344 
59 1 Y 1 R ARG 345 ? A ARG 345 
60 1 Y 1 R GLY 346 ? A GLY 346 
61 1 Y 1 R ASN 347 ? A ASN 347 
62 1 Y 1 R GLY 348 ? A GLY 348 
63 1 Y 1 R ARG 349 ? A ARG 349 
64 1 Y 1 R GLU 350 ? A GLU 350 
65 1 Y 1 R PHE 351 ? A PHE 351 
66 1 Y 1 R VAL 352 ? A VAL 352 
67 1 Y 1 R VAL 353 ? A VAL 353 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-07 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8ZFB 
_em_admin.last_update        2025-02-26 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Cryo-EM structure of the receptor of xtGPR4-Gs complex in pH7.2' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          8364 
_em_entity_assembly_naturalsource.organism             'Xenopus tropicalis' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         1.875 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           81773704 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8ZFB 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . LEU A 1 15  ? 160.061 176.543 132.363 1.00 115.09 ? 15  LEU R N   1 
ATOM 2    C CA  . LEU A 1 15  ? 160.711 177.684 132.995 1.00 115.09 ? 15  LEU R CA  1 
ATOM 3    C C   . LEU A 1 15  ? 160.631 177.529 134.504 1.00 115.09 ? 15  LEU R C   1 
ATOM 4    O O   . LEU A 1 15  ? 159.899 176.676 134.999 1.00 115.09 ? 15  LEU R O   1 
ATOM 5    C CB  . LEU A 1 15  ? 160.065 179.001 132.548 1.00 115.09 ? 15  LEU R CB  1 
ATOM 6    N N   . ASP A 1 16  ? 161.391 178.344 135.242 1.00 122.15 ? 16  ASP R N   1 
ATOM 7    C CA  . ASP A 1 16  ? 161.384 178.305 136.704 1.00 122.15 ? 16  ASP R CA  1 
ATOM 8    C C   . ASP A 1 16  ? 161.203 179.726 137.252 1.00 122.15 ? 16  ASP R C   1 
ATOM 9    O O   . ASP A 1 16  ? 162.166 180.410 137.602 1.00 122.15 ? 16  ASP R O   1 
ATOM 10   C CB  . ASP A 1 16  ? 162.658 177.650 137.238 1.00 122.15 ? 16  ASP R CB  1 
ATOM 11   C CG  . ASP A 1 16  ? 162.579 176.138 137.231 1.00 122.15 ? 16  ASP R CG  1 
ATOM 12   O OD1 . ASP A 1 16  ? 161.570 175.591 137.721 1.00 122.15 ? 16  ASP R OD1 1 
ATOM 13   O OD2 . ASP A 1 16  ? 163.521 175.492 136.733 1.00 122.15 ? 16  ASP R OD2 1 
ATOM 14   N N   . SER A 1 17  ? 159.943 180.152 137.349 1.00 124.34 ? 17  SER R N   1 
ATOM 15   C CA  . SER A 1 17  ? 159.573 181.351 138.082 1.00 124.34 ? 17  SER R CA  1 
ATOM 16   C C   . SER A 1 17  ? 158.627 181.038 139.218 1.00 124.34 ? 17  SER R C   1 
ATOM 17   O O   . SER A 1 17  ? 158.218 181.956 139.939 1.00 124.34 ? 17  SER R O   1 
ATOM 18   C CB  . SER A 1 17  ? 158.917 182.386 137.168 1.00 124.34 ? 17  SER R CB  1 
ATOM 19   O OG  . SER A 1 17  ? 158.321 183.408 137.946 1.00 124.34 ? 17  SER R OG  1 
ATOM 20   N N   . VAL A 1 18  ? 158.240 179.775 139.371 1.00 124.13 ? 18  VAL R N   1 
ATOM 21   C CA  . VAL A 1 18  ? 157.535 179.346 140.563 1.00 124.13 ? 18  VAL R CA  1 
ATOM 22   C C   . VAL A 1 18  ? 158.516 178.806 141.592 1.00 124.13 ? 18  VAL R C   1 
ATOM 23   O O   . VAL A 1 18  ? 158.250 178.871 142.794 1.00 124.13 ? 18  VAL R O   1 
ATOM 24   C CB  . VAL A 1 18  ? 156.468 178.305 140.187 1.00 124.13 ? 18  VAL R CB  1 
ATOM 25   C CG1 . VAL A 1 18  ? 155.775 177.751 141.424 1.00 124.13 ? 18  VAL R CG1 1 
ATOM 26   C CG2 . VAL A 1 18  ? 155.449 178.916 139.235 1.00 124.13 ? 18  VAL R CG2 1 
ATOM 27   N N   . LEU A 1 19  ? 159.678 178.324 141.140 1.00 115.24 ? 19  LEU R N   1 
ATOM 28   C CA  . LEU A 1 19  ? 160.550 177.554 142.027 1.00 115.24 ? 19  LEU R CA  1 
ATOM 29   C C   . LEU A 1 19  ? 161.144 178.393 143.152 1.00 115.24 ? 19  LEU R C   1 
ATOM 30   O O   . LEU A 1 19  ? 160.999 178.010 144.326 1.00 115.24 ? 19  LEU R O   1 
ATOM 31   C CB  . LEU A 1 19  ? 161.632 176.840 141.208 1.00 115.24 ? 19  LEU R CB  1 
ATOM 32   C CG  . LEU A 1 19  ? 162.591 175.939 141.986 1.00 115.24 ? 19  LEU R CG  1 
ATOM 33   C CD1 . LEU A 1 19  ? 161.836 174.788 142.640 1.00 115.24 ? 19  LEU R CD1 1 
ATOM 34   C CD2 . LEU A 1 19  ? 163.718 175.433 141.095 1.00 115.24 ? 19  LEU R CD2 1 
ATOM 35   N N   . PRO A 1 20  ? 161.869 179.458 142.812 1.00 115.45 ? 20  PRO R N   1 
ATOM 36   C CA  . PRO A 1 20  ? 162.537 180.278 143.827 1.00 115.45 ? 20  PRO R CA  1 
ATOM 37   C C   . PRO A 1 20  ? 161.643 180.713 144.983 1.00 115.45 ? 20  PRO R C   1 
ATOM 38   O O   . PRO A 1 20  ? 161.936 180.394 146.137 1.00 115.45 ? 20  PRO R O   1 
ATOM 39   C CB  . PRO A 1 20  ? 163.029 181.478 143.031 1.00 115.45 ? 20  PRO R CB  1 
ATOM 40   C CG  . PRO A 1 20  ? 163.253 180.939 141.658 1.00 115.45 ? 20  PRO R CG  1 
ATOM 41   C CD  . PRO A 1 20  ? 162.175 179.910 141.445 1.00 115.45 ? 20  PRO R CD  1 
ATOM 42   N N   . PRO A 1 21  ? 160.545 181.406 144.676 1.00 114.82 ? 21  PRO R N   1 
ATOM 43   C CA  . PRO A 1 21  ? 159.612 181.898 145.697 1.00 114.82 ? 21  PRO R CA  1 
ATOM 44   C C   . PRO A 1 21  ? 158.976 180.785 146.534 1.00 114.82 ? 21  PRO R C   1 
ATOM 45   O O   . PRO A 1 21  ? 158.817 180.961 147.741 1.00 114.82 ? 21  PRO R O   1 
ATOM 46   C CB  . PRO A 1 21  ? 158.544 182.632 144.880 1.00 114.82 ? 21  PRO R CB  1 
ATOM 47   C CG  . PRO A 1 21  ? 158.802 182.289 143.455 1.00 114.82 ? 21  PRO R CG  1 
ATOM 48   C CD  . PRO A 1 21  ? 160.254 181.965 143.351 1.00 114.82 ? 21  PRO R CD  1 
ATOM 49   N N   . SER A 1 22  ? 158.614 179.666 145.917 1.00 113.13 ? 22  SER R N   1 
ATOM 50   C CA  . SER A 1 22  ? 158.025 178.553 146.651 1.00 113.13 ? 22  SER R CA  1 
ATOM 51   C C   . SER A 1 22  ? 159.024 178.014 147.652 1.00 113.13 ? 22  SER R C   1 
ATOM 52   O O   . SER A 1 22  ? 158.684 177.731 148.807 1.00 113.13 ? 22  SER R O   1 
ATOM 53   C CB  . SER A 1 22  ? 157.622 177.442 145.691 1.00 113.13 ? 22  SER R CB  1 
ATOM 54   O OG  . SER A 1 22  ? 158.765 176.805 145.152 1.00 113.13 ? 22  SER R OG  1 
ATOM 55   N N   . LEU A 1 23  ? 160.275 177.895 147.223 1.00 111.05 ? 23  LEU R N   1 
ATOM 56   C CA  . LEU A 1 23  ? 161.352 177.419 148.084 1.00 111.05 ? 23  LEU R CA  1 
ATOM 57   C C   . LEU A 1 23  ? 161.566 178.393 149.229 1.00 111.05 ? 23  LEU R C   1 
ATOM 58   O O   . LEU A 1 23  ? 161.828 177.983 150.356 1.00 111.05 ? 23  LEU R O   1 
ATOM 59   C CB  . LEU A 1 23  ? 162.652 177.218 147.297 1.00 111.05 ? 23  LEU R CB  1 
ATOM 60   N N   . TYR A 1 24  ? 161.477 179.690 148.932 1.00 116.34 ? 24  TYR R N   1 
ATOM 61   C CA  . TYR A 1 24  ? 161.628 180.720 149.945 1.00 116.34 ? 24  TYR R CA  1 
ATOM 62   C C   . TYR A 1 24  ? 160.530 180.580 150.982 1.00 116.34 ? 24  TYR R C   1 
ATOM 63   O O   . TYR A 1 24  ? 160.782 180.701 152.179 1.00 116.34 ? 24  TYR R O   1 
ATOM 64   C CB  . TYR A 1 24  ? 161.569 182.103 149.320 1.00 116.34 ? 24  TYR R CB  1 
ATOM 65   C CG  . TYR A 1 24  ? 162.780 182.445 148.501 1.00 116.34 ? 24  TYR R CG  1 
ATOM 66   C CD1 . TYR A 1 24  ? 163.968 181.780 148.692 1.00 116.34 ? 24  TYR R CD1 1 
ATOM 67   C CD2 . TYR A 1 24  ? 162.739 183.462 147.560 1.00 116.34 ? 24  TYR R CD2 1 
ATOM 68   C CE1 . TYR A 1 24  ? 165.086 182.097 147.956 1.00 116.34 ? 24  TYR R CE1 1 
ATOM 69   C CE2 . TYR A 1 24  ? 163.855 183.788 146.819 1.00 116.34 ? 24  TYR R CE2 1 
ATOM 70   C CZ  . TYR A 1 24  ? 165.026 183.103 147.026 1.00 116.34 ? 24  TYR R CZ  1 
ATOM 71   O OH  . TYR A 1 24  ? 166.139 183.418 146.290 1.00 116.34 ? 24  TYR R OH  1 
ATOM 72   N N   . ALA A 1 25  ? 159.312 180.318 150.535 1.00 113.82 ? 25  ALA R N   1 
ATOM 73   C CA  . ALA A 1 25  ? 158.207 180.136 151.458 1.00 113.82 ? 25  ALA R CA  1 
ATOM 74   C C   . ALA A 1 25  ? 158.452 178.913 152.331 1.00 113.82 ? 25  ALA R C   1 
ATOM 75   O O   . ALA A 1 25  ? 158.164 178.936 153.525 1.00 113.82 ? 25  ALA R O   1 
ATOM 76   C CB  . ALA A 1 25  ? 156.895 179.999 150.705 1.00 113.82 ? 25  ALA R CB  1 
ATOM 77   N N   . LEU A 1 26  ? 158.990 177.852 151.738 1.00 112.58 ? 26  LEU R N   1 
ATOM 78   C CA  . LEU A 1 26  ? 159.278 176.632 152.483 1.00 112.58 ? 26  LEU R CA  1 
ATOM 79   C C   . LEU A 1 26  ? 160.364 176.896 153.523 1.00 112.58 ? 26  LEU R C   1 
ATOM 80   O O   . LEU A 1 26  ? 160.382 176.286 154.592 1.00 112.58 ? 26  LEU R O   1 
ATOM 81   C CB  . LEU A 1 26  ? 159.712 175.513 151.534 1.00 112.58 ? 26  LEU R CB  1 
ATOM 82   C CG  . LEU A 1 26  ? 159.985 174.146 152.164 1.00 112.58 ? 26  LEU R CG  1 
ATOM 83   C CD1 . LEU A 1 26  ? 161.201 174.201 153.076 1.00 112.58 ? 26  LEU R CD1 1 
ATOM 84   C CD2 . LEU A 1 26  ? 158.763 173.646 152.919 1.00 112.58 ? 26  LEU R CD2 1 
ATOM 85   N N   . VAL A 1 27  ? 161.265 177.816 153.195 1.00 112.87 ? 27  VAL R N   1 
ATOM 86   C CA  . VAL A 1 27  ? 162.363 178.191 154.080 1.00 112.87 ? 27  VAL R CA  1 
ATOM 87   C C   . VAL A 1 27  ? 161.851 179.071 155.209 1.00 112.87 ? 27  VAL R C   1 
ATOM 88   O O   . VAL A 1 27  ? 162.143 178.831 156.382 1.00 112.87 ? 27  VAL R O   1 
ATOM 89   C CB  . VAL A 1 27  ? 163.483 178.886 153.287 1.00 112.87 ? 27  VAL R CB  1 
ATOM 90   C CG1 . VAL A 1 27  ? 164.377 179.674 154.219 1.00 112.87 ? 27  VAL R CG1 1 
ATOM 91   C CG2 . VAL A 1 27  ? 164.297 177.861 152.515 1.00 112.87 ? 27  VAL R CG2 1 
ATOM 92   N N   . PHE A 1 28  ? 161.049 180.079 154.879 1.00 115.90 ? 28  PHE R N   1 
ATOM 93   C CA  . PHE A 1 28  ? 160.416 180.896 155.906 1.00 115.90 ? 28  PHE R CA  1 
ATOM 94   C C   . PHE A 1 28  ? 159.639 180.022 156.880 1.00 115.90 ? 28  PHE R C   1 
ATOM 95   O O   . PHE A 1 28  ? 160.034 179.873 158.046 1.00 115.90 ? 28  PHE R O   1 
ATOM 96   C CB  . PHE A 1 28  ? 159.484 181.926 155.261 1.00 115.90 ? 28  PHE R CB  1 
ATOM 97   C CG  . PHE A 1 28  ? 159.120 183.074 156.160 1.00 115.90 ? 28  PHE R CG  1 
ATOM 98   C CD1 . PHE A 1 28  ? 159.825 184.260 156.113 1.00 115.90 ? 28  PHE R CD1 1 
ATOM 99   C CD2 . PHE A 1 28  ? 158.055 182.970 157.036 1.00 115.90 ? 28  PHE R CD2 1 
ATOM 100  C CE1 . PHE A 1 28  ? 159.487 185.313 156.935 1.00 115.90 ? 28  PHE R CE1 1 
ATOM 101  C CE2 . PHE A 1 28  ? 157.710 184.022 157.857 1.00 115.90 ? 28  PHE R CE2 1 
ATOM 102  C CZ  . PHE A 1 28  ? 158.426 185.195 157.806 1.00 115.90 ? 28  PHE R CZ  1 
ATOM 103  N N   . THR A 1 29  ? 158.588 179.375 156.365 1.00 116.29 ? 29  THR R N   1 
ATOM 104  C CA  . THR A 1 29  ? 157.601 178.710 157.207 1.00 116.29 ? 29  THR R CA  1 
ATOM 105  C C   . THR A 1 29  ? 158.233 177.683 158.135 1.00 116.29 ? 29  THR R C   1 
ATOM 106  O O   . THR A 1 29  ? 157.758 177.495 159.261 1.00 116.29 ? 29  THR R O   1 
ATOM 107  C CB  . THR A 1 29  ? 156.536 178.050 156.328 1.00 116.29 ? 29  THR R CB  1 
ATOM 108  O OG1 . THR A 1 29  ? 155.826 179.059 155.599 1.00 116.29 ? 29  THR R OG1 1 
ATOM 109  C CG2 . THR A 1 29  ? 155.543 177.254 157.170 1.00 116.29 ? 29  THR R CG2 1 
ATOM 110  N N   . LEU A 1 30  ? 159.312 177.028 157.709 1.00 120.95 ? 30  LEU R N   1 
ATOM 111  C CA  . LEU A 1 30  ? 159.917 175.997 158.543 1.00 120.95 ? 30  LEU R CA  1 
ATOM 112  C C   . LEU A 1 30  ? 161.137 176.481 159.311 1.00 120.95 ? 30  LEU R C   1 
ATOM 113  O O   . LEU A 1 30  ? 161.233 176.243 160.520 1.00 120.95 ? 30  LEU R O   1 
ATOM 114  C CB  . LEU A 1 30  ? 160.286 174.773 157.692 1.00 120.95 ? 30  LEU R CB  1 
ATOM 115  C CG  . LEU A 1 30  ? 159.211 173.686 157.594 1.00 120.95 ? 30  LEU R CG  1 
ATOM 116  C CD1 . LEU A 1 30  ? 158.926 173.104 158.968 1.00 120.95 ? 30  LEU R CD1 1 
ATOM 117  C CD2 . LEU A 1 30  ? 157.931 174.210 156.961 1.00 120.95 ? 30  LEU R CD2 1 
ATOM 118  N N   . GLY A 1 31  ? 162.082 177.149 158.647 1.00 119.51 ? 31  GLY R N   1 
ATOM 119  C CA  . GLY A 1 31  ? 163.282 177.588 159.331 1.00 119.51 ? 31  GLY R CA  1 
ATOM 120  C C   . GLY A 1 31  ? 163.016 178.602 160.425 1.00 119.51 ? 31  GLY R C   1 
ATOM 121  O O   . GLY A 1 31  ? 163.581 178.501 161.515 1.00 119.51 ? 31  GLY R O   1 
ATOM 122  N N   . LEU A 1 32  ? 162.155 179.595 160.160 1.00 122.72 ? 32  LEU R N   1 
ATOM 123  C CA  . LEU A 1 32  ? 162.001 180.680 161.129 1.00 122.72 ? 32  LEU R CA  1 
ATOM 124  C C   . LEU A 1 32  ? 161.544 180.184 162.497 1.00 122.72 ? 32  LEU R C   1 
ATOM 125  O O   . LEU A 1 32  ? 162.164 180.571 163.504 1.00 122.72 ? 32  LEU R O   1 
ATOM 126  C CB  . LEU A 1 32  ? 161.068 181.756 160.558 1.00 122.72 ? 32  LEU R CB  1 
ATOM 127  C CG  . LEU A 1 32  ? 161.079 183.130 161.231 1.00 122.72 ? 32  LEU R CG  1 
ATOM 128  C CD1 . LEU A 1 32  ? 160.810 184.214 160.206 1.00 122.72 ? 32  LEU R CD1 1 
ATOM 129  C CD2 . LEU A 1 32  ? 160.054 183.206 162.349 1.00 122.72 ? 32  LEU R CD2 1 
ATOM 130  N N   . PRO A 1 33  ? 160.513 179.339 162.622 1.00 128.03 ? 33  PRO R N   1 
ATOM 131  C CA  . PRO A 1 33  ? 160.240 178.748 163.945 1.00 128.03 ? 33  PRO R CA  1 
ATOM 132  C C   . PRO A 1 33  ? 161.384 177.889 164.457 1.00 128.03 ? 33  PRO R C   1 
ATOM 133  O O   . PRO A 1 33  ? 161.761 177.980 165.637 1.00 128.03 ? 33  PRO R O   1 
ATOM 134  C CB  . PRO A 1 33  ? 158.969 177.924 163.697 1.00 128.03 ? 33  PRO R CB  1 
ATOM 135  C CG  . PRO A 1 33  ? 158.330 178.558 162.535 1.00 128.03 ? 33  PRO R CG  1 
ATOM 136  C CD  . PRO A 1 33  ? 159.455 178.996 161.656 1.00 128.03 ? 33  PRO R CD  1 
ATOM 137  N N   . ALA A 1 34  ? 161.950 177.047 163.590 1.00 119.64 ? 34  ALA R N   1 
ATOM 138  C CA  . ALA A 1 34  ? 163.066 176.204 163.998 1.00 119.64 ? 34  ALA R CA  1 
ATOM 139  C C   . ALA A 1 34  ? 164.286 177.036 164.358 1.00 119.64 ? 34  ALA R C   1 
ATOM 140  O O   . ALA A 1 34  ? 165.043 176.666 165.261 1.00 119.64 ? 34  ALA R O   1 
ATOM 141  C CB  . ALA A 1 34  ? 163.407 175.208 162.891 1.00 119.64 ? 34  ALA R CB  1 
ATOM 142  N N   . ASN A 1 35  ? 164.481 178.171 163.690 1.00 117.71 ? 35  ASN R N   1 
ATOM 143  C CA  . ASN A 1 35  ? 165.600 179.033 164.037 1.00 117.71 ? 35  ASN R CA  1 
ATOM 144  C C   . ASN A 1 35  ? 165.360 179.787 165.338 1.00 117.71 ? 35  ASN R C   1 
ATOM 145  O O   . ASN A 1 35  ? 166.312 180.027 166.082 1.00 117.71 ? 35  ASN R O   1 
ATOM 146  C CB  . ASN A 1 35  ? 165.892 180.005 162.897 1.00 117.71 ? 35  ASN R CB  1 
ATOM 147  C CG  . ASN A 1 35  ? 166.940 179.477 161.945 1.00 117.71 ? 35  ASN R CG  1 
ATOM 148  O OD1 . ASN A 1 35  ? 168.060 179.173 162.349 1.00 117.71 ? 35  ASN R OD1 1 
ATOM 149  N ND2 . ASN A 1 35  ? 166.584 179.368 160.671 1.00 117.71 ? 35  ASN R ND2 1 
ATOM 150  N N   . LEU A 1 36  ? 164.112 180.146 165.650 1.00 124.04 ? 36  LEU R N   1 
ATOM 151  C CA  . LEU A 1 36  ? 163.826 180.676 166.982 1.00 124.04 ? 36  LEU R CA  1 
ATOM 152  C C   . LEU A 1 36  ? 164.113 179.637 168.060 1.00 124.04 ? 36  LEU R C   1 
ATOM 153  O O   . LEU A 1 36  ? 164.682 179.955 169.116 1.00 124.04 ? 36  LEU R O   1 
ATOM 154  C CB  . LEU A 1 36  ? 162.373 181.145 167.068 1.00 124.04 ? 36  LEU R CB  1 
ATOM 155  C CG  . LEU A 1 36  ? 161.999 182.398 166.278 1.00 124.04 ? 36  LEU R CG  1 
ATOM 156  C CD1 . LEU A 1 36  ? 160.524 182.713 166.451 1.00 124.04 ? 36  LEU R CD1 1 
ATOM 157  C CD2 . LEU A 1 36  ? 162.850 183.574 166.724 1.00 124.04 ? 36  LEU R CD2 1 
ATOM 158  N N   . LEU A 1 37  ? 163.722 178.385 167.813 1.00 124.46 ? 37  LEU R N   1 
ATOM 159  C CA  . LEU A 1 37  ? 163.988 177.334 168.792 1.00 124.46 ? 37  LEU R CA  1 
ATOM 160  C C   . LEU A 1 37  ? 165.486 177.093 168.949 1.00 124.46 ? 37  LEU R C   1 
ATOM 161  O O   . LEU A 1 37  ? 165.972 176.882 170.065 1.00 124.46 ? 37  LEU R O   1 
ATOM 162  C CB  . LEU A 1 37  ? 163.261 176.050 168.396 1.00 124.46 ? 37  LEU R CB  1 
ATOM 163  C CG  . LEU A 1 37  ? 163.168 174.958 169.461 1.00 124.46 ? 37  LEU R CG  1 
ATOM 164  C CD1 . LEU A 1 37  ? 161.848 174.224 169.340 1.00 124.46 ? 37  LEU R CD1 1 
ATOM 165  C CD2 . LEU A 1 37  ? 164.327 173.980 169.338 1.00 124.46 ? 37  LEU R CD2 1 
ATOM 166  N N   . ALA A 1 38  ? 166.235 177.128 167.845 1.00 118.65 ? 38  ALA R N   1 
ATOM 167  C CA  . ALA A 1 38  ? 167.687 177.014 167.930 1.00 118.65 ? 38  ALA R CA  1 
ATOM 168  C C   . ALA A 1 38  ? 168.300 178.207 168.645 1.00 118.65 ? 38  ALA R C   1 
ATOM 169  O O   . ALA A 1 38  ? 169.308 178.059 169.341 1.00 118.65 ? 38  ALA R O   1 
ATOM 170  C CB  . ALA A 1 38  ? 168.290 176.867 166.535 1.00 118.65 ? 38  ALA R CB  1 
ATOM 171  N N   . LEU A 1 39  ? 167.711 179.392 168.481 1.00 122.10 ? 39  LEU R N   1 
ATOM 172  C CA  . LEU A 1 39  ? 168.154 180.570 169.216 1.00 122.10 ? 39  LEU R CA  1 
ATOM 173  C C   . LEU A 1 39  ? 168.025 180.345 170.717 1.00 122.10 ? 39  LEU R C   1 
ATOM 174  O O   . LEU A 1 39  ? 168.966 180.594 171.485 1.00 122.10 ? 39  LEU R O   1 
ATOM 175  C CB  . LEU A 1 39  ? 167.321 181.773 168.767 1.00 122.10 ? 39  LEU R CB  1 
ATOM 176  C CG  . LEU A 1 39  ? 167.444 183.157 169.400 1.00 122.10 ? 39  LEU R CG  1 
ATOM 177  C CD1 . LEU A 1 39  ? 168.880 183.588 169.437 1.00 122.10 ? 39  LEU R CD1 1 
ATOM 178  C CD2 . LEU A 1 39  ? 166.604 184.164 168.633 1.00 122.10 ? 39  LEU R CD2 1 
ATOM 179  N N   . TRP A 1 40  ? 166.864 179.848 171.148 1.00 127.80 ? 40  TRP R N   1 
ATOM 180  C CA  . TRP A 1 40  ? 166.670 179.563 172.568 1.00 127.80 ? 40  TRP R CA  1 
ATOM 181  C C   . TRP A 1 40  ? 167.608 178.466 173.052 1.00 127.80 ? 40  TRP R C   1 
ATOM 182  O O   . TRP A 1 40  ? 168.143 178.548 174.164 1.00 127.80 ? 40  TRP R O   1 
ATOM 183  C CB  . TRP A 1 40  ? 165.221 179.179 172.850 1.00 127.80 ? 40  TRP R CB  1 
ATOM 184  C CG  . TRP A 1 40  ? 164.844 179.338 174.289 1.00 127.80 ? 40  TRP R CG  1 
ATOM 185  C CD1 . TRP A 1 40  ? 164.332 178.376 175.108 1.00 127.80 ? 40  TRP R CD1 1 
ATOM 186  C CD2 . TRP A 1 40  ? 164.949 180.526 175.084 1.00 127.80 ? 40  TRP R CD2 1 
ATOM 187  N NE1 . TRP A 1 40  ? 164.111 178.889 176.361 1.00 127.80 ? 40  TRP R NE1 1 
ATOM 188  C CE2 . TRP A 1 40  ? 164.481 180.207 176.373 1.00 127.80 ? 40  TRP R CE2 1 
ATOM 189  C CE3 . TRP A 1 40  ? 165.390 181.829 174.830 1.00 127.80 ? 40  TRP R CE3 1 
ATOM 190  C CZ2 . TRP A 1 40  ? 164.442 181.142 177.406 1.00 127.80 ? 40  TRP R CZ2 1 
ATOM 191  C CZ3 . TRP A 1 40  ? 165.352 182.755 175.857 1.00 127.80 ? 40  TRP R CZ3 1 
ATOM 192  C CH2 . TRP A 1 40  ? 164.882 182.407 177.129 1.00 127.80 ? 40  TRP R CH2 1 
ATOM 193  N N   . ALA A 1 41  ? 167.806 177.425 172.241 1.00 122.98 ? 41  ALA R N   1 
ATOM 194  C CA  . ALA A 1 41  ? 168.713 176.350 172.630 1.00 122.98 ? 41  ALA R CA  1 
ATOM 195  C C   . ALA A 1 41  ? 170.135 176.866 172.800 1.00 122.98 ? 41  ALA R C   1 
ATOM 196  O O   . ALA A 1 41  ? 170.820 176.515 173.767 1.00 122.98 ? 41  ALA R O   1 
ATOM 197  C CB  . ALA A 1 41  ? 168.669 175.224 171.598 1.00 122.98 ? 41  ALA R CB  1 
ATOM 198  N N   . ALA A 1 42  ? 170.591 177.715 171.879 1.00 115.26 ? 42  ALA R N   1 
ATOM 199  C CA  . ALA A 1 42  ? 171.937 178.261 171.973 1.00 115.26 ? 42  ALA R CA  1 
ATOM 200  C C   . ALA A 1 42  ? 172.085 179.162 173.191 1.00 115.26 ? 42  ALA R C   1 
ATOM 201  O O   . ALA A 1 42  ? 173.124 179.137 173.864 1.00 115.26 ? 42  ALA R O   1 
ATOM 202  C CB  . ALA A 1 42  ? 172.286 179.023 170.697 1.00 115.26 ? 42  ALA R CB  1 
ATOM 203  N N   . TRP A 1 43  ? 171.062 179.966 173.498 1.00 120.66 ? 43  TRP R N   1 
ATOM 204  C CA  . TRP A 1 43  ? 171.175 180.828 174.672 1.00 120.66 ? 43  TRP R CA  1 
ATOM 205  C C   . TRP A 1 43  ? 171.159 180.019 175.965 1.00 120.66 ? 43  TRP R C   1 
ATOM 206  O O   . TRP A 1 43  ? 171.909 180.320 176.901 1.00 120.66 ? 43  TRP R O   1 
ATOM 207  C CB  . TRP A 1 43  ? 170.068 181.878 174.693 1.00 120.66 ? 43  TRP R CB  1 
ATOM 208  C CG  . TRP A 1 43  ? 170.145 182.719 175.927 1.00 120.66 ? 43  TRP R CG  1 
ATOM 209  C CD1 . TRP A 1 43  ? 169.313 182.672 177.003 1.00 120.66 ? 43  TRP R CD1 1 
ATOM 210  C CD2 . TRP A 1 43  ? 171.135 183.705 176.228 1.00 120.66 ? 43  TRP R CD2 1 
ATOM 211  N NE1 . TRP A 1 43  ? 169.712 183.580 177.949 1.00 120.66 ? 43  TRP R NE1 1 
ATOM 212  C CE2 . TRP A 1 43  ? 170.830 184.228 177.497 1.00 120.66 ? 43  TRP R CE2 1 
ATOM 213  C CE3 . TRP A 1 43  ? 172.244 184.208 175.540 1.00 120.66 ? 43  TRP R CE3 1 
ATOM 214  C CZ2 . TRP A 1 43  ? 171.594 185.226 178.096 1.00 120.66 ? 43  TRP R CZ2 1 
ATOM 215  C CZ3 . TRP A 1 43  ? 173.003 185.197 176.139 1.00 120.66 ? 43  TRP R CZ3 1 
ATOM 216  C CH2 . TRP A 1 43  ? 172.673 185.696 177.403 1.00 120.66 ? 43  TRP R CH2 1 
ATOM 217  N N   . LEU A 1 44  ? 170.315 178.990 176.045 1.00 121.14 ? 44  LEU R N   1 
ATOM 218  C CA  . LEU A 1 44  ? 170.319 178.165 177.245 1.00 121.14 ? 44  LEU R CA  1 
ATOM 219  C C   . LEU A 1 44  ? 171.580 177.318 177.341 1.00 121.14 ? 44  LEU R C   1 
ATOM 220  O O   . LEU A 1 44  ? 171.962 176.916 178.446 1.00 121.14 ? 44  LEU R O   1 
ATOM 221  C CB  . LEU A 1 44  ? 169.067 177.293 177.290 1.00 121.14 ? 44  LEU R CB  1 
ATOM 222  C CG  . LEU A 1 44  ? 168.788 176.563 178.604 1.00 121.14 ? 44  LEU R CG  1 
ATOM 223  C CD1 . LEU A 1 44  ? 167.302 176.580 178.904 1.00 121.14 ? 44  LEU R CD1 1 
ATOM 224  C CD2 . LEU A 1 44  ? 169.292 175.128 178.551 1.00 121.14 ? 44  LEU R CD2 1 
ATOM 225  N N   . GLN A 1 45  ? 172.242 177.055 176.214 1.00 115.51 ? 45  GLN R N   1 
ATOM 226  C CA  . GLN A 1 45  ? 173.547 176.406 176.254 1.00 115.51 ? 45  GLN R CA  1 
ATOM 227  C C   . GLN A 1 45  ? 174.615 177.353 176.783 1.00 115.51 ? 45  GLN R C   1 
ATOM 228  O O   . GLN A 1 45  ? 175.436 176.966 177.624 1.00 115.51 ? 45  GLN R O   1 
ATOM 229  C CB  . GLN A 1 45  ? 173.917 175.906 174.859 1.00 115.51 ? 45  GLN R CB  1 
ATOM 230  C CG  . GLN A 1 45  ? 175.187 175.082 174.805 1.00 115.51 ? 45  GLN R CG  1 
ATOM 231  C CD  . GLN A 1 45  ? 175.434 174.494 173.432 1.00 115.51 ? 45  GLN R CD  1 
ATOM 232  O OE1 . GLN A 1 45  ? 174.655 174.708 172.503 1.00 115.51 ? 45  GLN R OE1 1 
ATOM 233  N NE2 . GLN A 1 45  ? 176.525 173.749 173.294 1.00 115.51 ? 45  GLN R NE2 1 
ATOM 234  N N   . VAL A 1 46  ? 174.619 178.600 176.307 1.00 116.96 ? 46  VAL R N   1 
ATOM 235  C CA  . VAL A 1 46  ? 175.623 179.566 176.745 1.00 116.96 ? 46  VAL R CA  1 
ATOM 236  C C   . VAL A 1 46  ? 175.355 180.078 178.150 1.00 116.96 ? 46  VAL R C   1 
ATOM 237  O O   . VAL A 1 46  ? 176.241 180.694 178.757 1.00 116.96 ? 46  VAL R O   1 
ATOM 238  C CB  . VAL A 1 46  ? 175.706 180.740 175.750 1.00 116.96 ? 46  VAL R CB  1 
ATOM 239  C CG1 . VAL A 1 46  ? 174.506 181.639 175.884 1.00 116.96 ? 46  VAL R CG1 1 
ATOM 240  C CG2 . VAL A 1 46  ? 176.998 181.523 175.922 1.00 116.96 ? 46  VAL R CG2 1 
ATOM 241  N N   . ARG A 1 47  ? 174.159 179.836 178.693 1.00 117.03 ? 47  ARG R N   1 
ATOM 242  C CA  . ARG A 1 47  ? 173.899 180.202 180.080 1.00 117.03 ? 47  ARG R CA  1 
ATOM 243  C C   . ARG A 1 47  ? 174.755 179.411 181.059 1.00 117.03 ? 47  ARG R C   1 
ATOM 244  O O   . ARG A 1 47  ? 174.928 179.846 182.201 1.00 117.03 ? 47  ARG R O   1 
ATOM 245  C CB  . ARG A 1 47  ? 172.419 180.013 180.410 1.00 30.00  ? 47  ARG R CB  1 
ATOM 246  C CG  . ARG A 1 47  ? 171.552 181.227 180.112 1.00 30.00  ? 47  ARG R CG  1 
ATOM 247  C CD  . ARG A 1 47  ? 171.730 182.301 181.174 1.00 30.00  ? 47  ARG R CD  1 
ATOM 248  N NE  . ARG A 1 47  ? 170.646 183.279 181.155 1.00 30.00  ? 47  ARG R NE  1 
ATOM 249  C CZ  . ARG A 1 47  ? 170.439 184.184 182.107 1.00 30.00  ? 47  ARG R CZ  1 
ATOM 250  N NH1 . ARG A 1 47  ? 171.243 184.238 183.160 1.00 30.00  ? 47  ARG R NH1 1 
ATOM 251  N NH2 . ARG A 1 47  ? 169.427 185.034 182.007 1.00 30.00  ? 47  ARG R NH2 1 
ATOM 252  N N   . LYS A 1 48  ? 175.297 178.267 180.641 1.00 129.60 ? 48  LYS R N   1 
ATOM 253  C CA  . LYS A 1 48  ? 176.198 177.483 181.474 1.00 129.60 ? 48  LYS R CA  1 
ATOM 254  C C   . LYS A 1 48  ? 177.668 177.801 181.232 1.00 129.60 ? 48  LYS R C   1 
ATOM 255  O O   . LYS A 1 48  ? 178.524 177.278 181.952 1.00 129.60 ? 48  LYS R O   1 
ATOM 256  C CB  . LYS A 1 48  ? 175.962 175.985 181.250 1.00 129.60 ? 48  LYS R CB  1 
ATOM 257  C CG  . LYS A 1 48  ? 174.507 175.586 181.240 1.00 129.60 ? 48  LYS R CG  1 
ATOM 258  C CD  . LYS A 1 48  ? 174.348 174.102 180.968 1.00 129.60 ? 48  LYS R CD  1 
ATOM 259  C CE  . LYS A 1 48  ? 172.932 173.640 181.260 1.00 129.60 ? 48  LYS R CE  1 
ATOM 260  N NZ  . LYS A 1 48  ? 171.927 174.669 180.876 1.00 129.60 ? 48  LYS R NZ  1 
ATOM 261  N N   . GLY A 1 49  ? 177.978 178.639 180.249 1.00 122.68 ? 49  GLY R N   1 
ATOM 262  C CA  . GLY A 1 49  ? 179.355 178.965 179.942 1.00 122.68 ? 49  GLY R CA  1 
ATOM 263  C C   . GLY A 1 49  ? 179.961 178.072 178.881 1.00 122.68 ? 49  GLY R C   1 
ATOM 264  O O   . GLY A 1 49  ? 181.038 177.504 179.080 1.00 122.68 ? 49  GLY R O   1 
ATOM 265  N N   . ARG A 1 50  ? 179.278 177.939 177.749 1.00 110.20 ? 50  ARG R N   1 
ATOM 266  C CA  . ARG A 1 50  ? 179.747 177.145 176.619 1.00 110.20 ? 50  ARG R CA  1 
ATOM 267  C C   . ARG A 1 50  ? 180.283 178.081 175.545 1.00 110.20 ? 50  ARG R C   1 
ATOM 268  O O   . ARG A 1 50  ? 179.570 178.981 175.090 1.00 110.20 ? 50  ARG R O   1 
ATOM 269  C CB  . ARG A 1 50  ? 178.623 176.276 176.054 1.00 110.20 ? 50  ARG R CB  1 
ATOM 270  C CG  . ARG A 1 50  ? 178.080 175.214 176.998 1.00 110.20 ? 50  ARG R CG  1 
ATOM 271  C CD  . ARG A 1 50  ? 179.099 174.118 177.239 1.00 110.20 ? 50  ARG R CD  1 
ATOM 272  N NE  . ARG A 1 50  ? 178.555 173.033 178.048 1.00 110.20 ? 50  ARG R NE  1 
ATOM 273  C CZ  . ARG A 1 50  ? 178.627 172.978 179.372 1.00 110.20 ? 50  ARG R CZ  1 
ATOM 274  N NH1 . ARG A 1 50  ? 179.225 173.951 180.045 1.00 110.20 ? 50  ARG R NH1 1 
ATOM 275  N NH2 . ARG A 1 50  ? 178.103 171.950 180.024 1.00 110.20 ? 50  ARG R NH2 1 
ATOM 276  N N   . GLU A 1 51  ? 181.539 177.865 175.141 1.00 87.44  ? 51  GLU R N   1 
ATOM 277  C CA  . GLU A 1 51  ? 182.152 178.711 174.121 1.00 87.44  ? 51  GLU R CA  1 
ATOM 278  C C   . GLU A 1 51  ? 181.417 178.600 172.792 1.00 87.44  ? 51  GLU R C   1 
ATOM 279  O O   . GLU A 1 51  ? 181.210 179.605 172.102 1.00 87.44  ? 51  GLU R O   1 
ATOM 280  C CB  . GLU A 1 51  ? 183.624 178.339 173.949 1.00 87.44  ? 51  GLU R CB  1 
ATOM 281  C CG  . GLU A 1 51  ? 184.334 179.109 172.850 1.00 87.44  ? 51  GLU R CG  1 
ATOM 282  C CD  . GLU A 1 51  ? 185.844 179.062 172.986 1.00 87.44  ? 51  GLU R CD  1 
ATOM 283  O OE1 . GLU A 1 51  ? 186.343 178.288 173.829 1.00 87.44  ? 51  GLU R OE1 1 
ATOM 284  O OE2 . GLU A 1 51  ? 186.532 179.802 172.251 1.00 87.44  ? 51  GLU R OE2 1 
ATOM 285  N N   . LEU A 1 52  ? 181.020 177.382 172.415 1.00 87.96  ? 52  LEU R N   1 
ATOM 286  C CA  . LEU A 1 52  ? 180.278 177.172 171.176 1.00 87.96  ? 52  LEU R CA  1 
ATOM 287  C C   . LEU A 1 52  ? 178.936 177.892 171.180 1.00 87.96  ? 52  LEU R C   1 
ATOM 288  O O   . LEU A 1 52  ? 178.349 178.105 170.109 1.00 87.96  ? 52  LEU R O   1 
ATOM 289  C CB  . LEU A 1 52  ? 180.071 175.672 170.955 1.00 87.96  ? 52  LEU R CB  1 
ATOM 290  C CG  . LEU A 1 52  ? 180.047 175.139 169.524 1.00 87.96  ? 52  LEU R CG  1 
ATOM 291  C CD1 . LEU A 1 52  ? 181.243 175.642 168.743 1.00 87.96  ? 52  LEU R CD1 1 
ATOM 292  C CD2 . LEU A 1 52  ? 180.014 173.623 169.533 1.00 87.96  ? 52  LEU R CD2 1 
ATOM 293  N N   . GLY A 1 53  ? 178.445 178.266 172.363 1.00 91.94  ? 53  GLY R N   1 
ATOM 294  C CA  . GLY A 1 53  ? 177.128 178.869 172.457 1.00 91.94  ? 53  GLY R CA  1 
ATOM 295  C C   . GLY A 1 53  ? 177.019 180.188 171.720 1.00 91.94  ? 53  GLY R C   1 
ATOM 296  O O   . GLY A 1 53  ? 176.026 180.444 171.041 1.00 91.94  ? 53  GLY R O   1 
ATOM 297  N N   . VAL A 1 54  ? 178.035 181.045 171.842 1.00 88.96  ? 54  VAL R N   1 
ATOM 298  C CA  . VAL A 1 54  ? 177.964 182.357 171.203 1.00 88.96  ? 54  VAL R CA  1 
ATOM 299  C C   . VAL A 1 54  ? 178.019 182.225 169.684 1.00 88.96  ? 54  VAL R C   1 
ATOM 300  O O   . VAL A 1 54  ? 177.300 182.927 168.960 1.00 88.96  ? 54  VAL R O   1 
ATOM 301  C CB  . VAL A 1 54  ? 179.072 183.277 171.745 1.00 88.96  ? 54  VAL R CB  1 
ATOM 302  C CG1 . VAL A 1 54  ? 178.867 183.525 173.228 1.00 88.96  ? 54  VAL R CG1 1 
ATOM 303  C CG2 . VAL A 1 54  ? 180.422 182.668 171.511 1.00 88.96  ? 54  VAL R CG2 1 
ATOM 304  N N   . TYR A 1 55  ? 178.870 181.329 169.175 1.00 86.65  ? 55  TYR R N   1 
ATOM 305  C CA  . TYR A 1 55  ? 178.933 181.109 167.735 1.00 86.65  ? 55  TYR R CA  1 
ATOM 306  C C   . TYR A 1 55  ? 177.612 180.567 167.206 1.00 86.65  ? 55  TYR R C   1 
ATOM 307  O O   . TYR A 1 55  ? 177.127 181.003 166.152 1.00 86.65  ? 55  TYR R O   1 
ATOM 308  C CB  . TYR A 1 55  ? 180.078 180.157 167.400 1.00 86.65  ? 55  TYR R CB  1 
ATOM 309  C CG  . TYR A 1 55  ? 181.415 180.551 167.984 1.00 86.65  ? 55  TYR R CG  1 
ATOM 310  C CD1 . TYR A 1 55  ? 182.113 181.645 167.497 1.00 86.65  ? 55  TYR R CD1 1 
ATOM 311  C CD2 . TYR A 1 55  ? 181.985 179.819 169.012 1.00 86.65  ? 55  TYR R CD2 1 
ATOM 312  C CE1 . TYR A 1 55  ? 183.337 182.003 168.024 1.00 86.65  ? 55  TYR R CE1 1 
ATOM 313  C CE2 . TYR A 1 55  ? 183.207 180.169 169.545 1.00 86.65  ? 55  TYR R CE2 1 
ATOM 314  C CZ  . TYR A 1 55  ? 183.879 181.261 169.046 1.00 86.65  ? 55  TYR R CZ  1 
ATOM 315  O OH  . TYR A 1 55  ? 185.097 181.613 169.575 1.00 86.65  ? 55  TYR R OH  1 
ATOM 316  N N   . LEU A 1 56  ? 177.008 179.619 167.929 1.00 91.57  ? 56  LEU R N   1 
ATOM 317  C CA  . LEU A 1 56  ? 175.707 179.102 167.515 1.00 91.57  ? 56  LEU R CA  1 
ATOM 318  C C   . LEU A 1 56  ? 174.644 180.193 167.568 1.00 91.57  ? 56  LEU R C   1 
ATOM 319  O O   . LEU A 1 56  ? 173.777 180.277 166.687 1.00 91.57  ? 56  LEU R O   1 
ATOM 320  C CB  . LEU A 1 56  ? 175.315 177.922 168.399 1.00 91.57  ? 56  LEU R CB  1 
ATOM 321  C CG  . LEU A 1 56  ? 175.811 176.569 167.897 1.00 91.57  ? 56  LEU R CG  1 
ATOM 322  C CD1 . LEU A 1 56  ? 175.775 175.532 169.005 1.00 91.57  ? 56  LEU R CD1 1 
ATOM 323  C CD2 . LEU A 1 56  ? 174.976 176.131 166.717 1.00 91.57  ? 56  LEU R CD2 1 
ATOM 324  N N   . LEU A 1 57  ? 174.706 181.038 168.597 1.00 93.93  ? 57  LEU R N   1 
ATOM 325  C CA  . LEU A 1 57  ? 173.784 182.157 168.737 1.00 93.93  ? 57  LEU R CA  1 
ATOM 326  C C   . LEU A 1 57  ? 173.859 183.070 167.523 1.00 93.93  ? 57  LEU R C   1 
ATOM 327  O O   . LEU A 1 57  ? 172.835 183.465 166.956 1.00 93.93  ? 57  LEU R O   1 
ATOM 328  C CB  . LEU A 1 57  ? 174.135 182.929 170.011 1.00 93.93  ? 57  LEU R CB  1 
ATOM 329  C CG  . LEU A 1 57  ? 173.296 184.098 170.517 1.00 93.93  ? 57  LEU R CG  1 
ATOM 330  C CD1 . LEU A 1 57  ? 171.947 183.600 170.958 1.00 93.93  ? 57  LEU R CD1 1 
ATOM 331  C CD2 . LEU A 1 57  ? 174.004 184.812 171.656 1.00 93.93  ? 57  LEU R CD2 1 
ATOM 332  N N   . ASN A 1 58  ? 175.079 183.401 167.102 1.00 90.46  ? 58  ASN R N   1 
ATOM 333  C CA  . ASN A 1 58  ? 175.255 184.319 165.983 1.00 90.46  ? 58  ASN R CA  1 
ATOM 334  C C   . ASN A 1 58  ? 174.841 183.681 164.661 1.00 90.46  ? 58  ASN R C   1 
ATOM 335  O O   . ASN A 1 58  ? 174.268 184.353 163.793 1.00 90.46  ? 58  ASN R O   1 
ATOM 336  C CB  . ASN A 1 58  ? 176.703 184.786 165.933 1.00 90.46  ? 58  ASN R CB  1 
ATOM 337  C CG  . ASN A 1 58  ? 177.022 185.784 167.018 1.00 90.46  ? 58  ASN R CG  1 
ATOM 338  O OD1 . ASN A 1 58  ? 177.928 185.573 167.821 1.00 90.46  ? 58  ASN R OD1 1 
ATOM 339  N ND2 . ASN A 1 58  ? 176.275 186.880 167.053 1.00 90.46  ? 58  ASN R ND2 1 
ATOM 340  N N   . LEU A 1 59  ? 175.130 182.390 164.481 1.00 86.67  ? 59  LEU R N   1 
ATOM 341  C CA  . LEU A 1 59  ? 174.678 181.702 163.275 1.00 86.67  ? 59  LEU R CA  1 
ATOM 342  C C   . LEU A 1 59  ? 173.155 181.698 163.188 1.00 86.67  ? 59  LEU R C   1 
ATOM 343  O O   . LEU A 1 59  ? 172.580 181.969 162.123 1.00 86.67  ? 59  LEU R O   1 
ATOM 344  C CB  . LEU A 1 59  ? 175.227 180.275 163.253 1.00 86.67  ? 59  LEU R CB  1 
ATOM 345  C CG  . LEU A 1 59  ? 174.827 179.390 162.073 1.00 86.67  ? 59  LEU R CG  1 
ATOM 346  C CD1 . LEU A 1 59  ? 175.611 179.770 160.829 1.00 86.67  ? 59  LEU R CD1 1 
ATOM 347  C CD2 . LEU A 1 59  ? 175.030 177.922 162.410 1.00 86.67  ? 59  LEU R CD2 1 
ATOM 348  N N   . SER A 1 60  ? 172.484 181.415 164.306 1.00 90.81  ? 60  SER R N   1 
ATOM 349  C CA  . SER A 1 60  ? 171.027 181.480 164.323 1.00 90.81  ? 60  SER R CA  1 
ATOM 350  C C   . SER A 1 60  ? 170.535 182.897 164.056 1.00 90.81  ? 60  SER R C   1 
ATOM 351  O O   . SER A 1 60  ? 169.515 183.089 163.386 1.00 90.81  ? 60  SER R O   1 
ATOM 352  C CB  . SER A 1 60  ? 170.490 180.970 165.659 1.00 90.81  ? 60  SER R CB  1 
ATOM 353  O OG  . SER A 1 60  ? 169.094 181.181 165.753 1.00 90.81  ? 60  SER R OG  1 
ATOM 354  N N   . LEU A 1 61  ? 171.239 183.901 164.582 1.00 91.77  ? 61  LEU R N   1 
ATOM 355  C CA  . LEU A 1 61  ? 170.866 185.289 164.321 1.00 91.77  ? 61  LEU R CA  1 
ATOM 356  C C   . LEU A 1 61  ? 170.903 185.592 162.828 1.00 91.77  ? 61  LEU R C   1 
ATOM 357  O O   . LEU A 1 61  ? 169.981 186.208 162.278 1.00 91.77  ? 61  LEU R O   1 
ATOM 358  C CB  . LEU A 1 61  ? 171.801 186.224 165.089 1.00 91.77  ? 61  LEU R CB  1 
ATOM 359  C CG  . LEU A 1 61  ? 171.370 187.672 165.310 1.00 91.77  ? 61  LEU R CG  1 
ATOM 360  C CD1 . LEU A 1 61  ? 170.018 187.730 166.000 1.00 91.77  ? 61  LEU R CD1 1 
ATOM 361  C CD2 . LEU A 1 61  ? 172.417 188.403 166.128 1.00 91.77  ? 61  LEU R CD2 1 
ATOM 362  N N   . SER A 1 62  ? 171.966 185.152 162.153 1.00 89.78  ? 62  SER R N   1 
ATOM 363  C CA  . SER A 1 62  ? 172.061 185.353 160.711 1.00 89.78  ? 62  SER R CA  1 
ATOM 364  C C   . SER A 1 62  ? 170.943 184.621 159.979 1.00 89.78  ? 62  SER R C   1 
ATOM 365  O O   . SER A 1 62  ? 170.402 185.124 158.983 1.00 89.78  ? 62  SER R O   1 
ATOM 366  C CB  . SER A 1 62  ? 173.426 184.890 160.209 1.00 89.78  ? 62  SER R CB  1 
ATOM 367  O OG  . SER A 1 62  ? 174.453 185.389 161.043 1.00 89.78  ? 62  SER R OG  1 
ATOM 368  N N   . ASP A 1 63  ? 170.593 183.424 160.450 1.00 93.28  ? 63  ASP R N   1 
ATOM 369  C CA  . ASP A 1 63  ? 169.485 182.694 159.841 1.00 93.28  ? 63  ASP R CA  1 
ATOM 370  C C   . ASP A 1 63  ? 168.170 183.458 159.982 1.00 93.28  ? 63  ASP R C   1 
ATOM 371  O O   . ASP A 1 63  ? 167.383 183.536 159.030 1.00 93.28  ? 63  ASP R O   1 
ATOM 372  C CB  . ASP A 1 63  ? 169.374 181.303 160.460 1.00 93.28  ? 63  ASP R CB  1 
ATOM 373  N N   . LEU A 1 64  ? 167.913 184.027 161.165 1.00 98.88  ? 64  LEU R N   1 
ATOM 374  C CA  . LEU A 1 64  ? 166.721 184.856 161.340 1.00 98.88  ? 64  LEU R CA  1 
ATOM 375  C C   . LEU A 1 64  ? 166.743 186.066 160.420 1.00 98.88  ? 64  LEU R C   1 
ATOM 376  O O   . LEU A 1 64  ? 165.699 186.476 159.900 1.00 98.88  ? 64  LEU R O   1 
ATOM 377  C CB  . LEU A 1 64  ? 166.565 185.317 162.791 1.00 98.88  ? 64  LEU R CB  1 
ATOM 378  C CG  . LEU A 1 64  ? 165.912 184.443 163.868 1.00 98.88  ? 64  LEU R CG  1 
ATOM 379  C CD1 . LEU A 1 64  ? 164.450 184.202 163.514 1.00 98.88  ? 64  LEU R CD1 1 
ATOM 380  C CD2 . LEU A 1 64  ? 166.622 183.139 164.117 1.00 98.88  ? 64  LEU R CD2 1 
ATOM 381  N N   . LEU A 1 65  ? 167.913 186.675 160.231 1.00 99.49  ? 65  LEU R N   1 
ATOM 382  C CA  . LEU A 1 65  ? 167.986 187.830 159.341 1.00 99.49  ? 65  LEU R CA  1 
ATOM 383  C C   . LEU A 1 65  ? 167.677 187.447 157.894 1.00 99.49  ? 65  LEU R C   1 
ATOM 384  O O   . LEU A 1 65  ? 166.957 188.175 157.199 1.00 99.49  ? 65  LEU R O   1 
ATOM 385  C CB  . LEU A 1 65  ? 169.348 188.507 159.464 1.00 99.49  ? 65  LEU R CB  1 
ATOM 386  C CG  . LEU A 1 65  ? 169.444 189.682 160.442 1.00 99.49  ? 65  LEU R CG  1 
ATOM 387  C CD1 . LEU A 1 65  ? 169.311 189.238 161.888 1.00 99.49  ? 65  LEU R CD1 1 
ATOM 388  C CD2 . LEU A 1 65  ? 170.746 190.441 160.233 1.00 99.49  ? 65  LEU R CD2 1 
ATOM 389  N N   . LEU A 1 66  ? 168.189 186.305 157.422 1.00 99.77  ? 66  LEU R N   1 
ATOM 390  C CA  . LEU A 1 66  ? 167.785 185.824 156.098 1.00 99.77  ? 66  LEU R CA  1 
ATOM 391  C C   . LEU A 1 66  ? 166.286 185.566 156.031 1.00 99.77  ? 66  LEU R C   1 
ATOM 392  O O   . LEU A 1 66  ? 165.630 185.919 155.040 1.00 99.77  ? 66  LEU R O   1 
ATOM 393  C CB  . LEU A 1 66  ? 168.538 184.551 155.715 1.00 99.77  ? 66  LEU R CB  1 
ATOM 394  C CG  . LEU A 1 66  ? 170.033 184.591 155.453 1.00 99.77  ? 66  LEU R CG  1 
ATOM 395  C CD1 . LEU A 1 66  ? 170.561 183.188 155.238 1.00 99.77  ? 66  LEU R CD1 1 
ATOM 396  C CD2 . LEU A 1 66  ? 170.264 185.425 154.210 1.00 99.77  ? 66  LEU R CD2 1 
ATOM 397  N N   . ILE A 1 67  ? 165.728 184.939 157.068 1.00 106.56 ? 67  ILE R N   1 
ATOM 398  C CA  . ILE A 1 67  ? 164.309 184.603 157.052 1.00 106.56 ? 67  ILE R CA  1 
ATOM 399  C C   . ILE A 1 67  ? 163.463 185.867 156.990 1.00 106.56 ? 67  ILE R C   1 
ATOM 400  O O   . ILE A 1 67  ? 162.460 185.924 156.269 1.00 106.56 ? 67  ILE R O   1 
ATOM 401  C CB  . ILE A 1 67  ? 163.952 183.740 158.276 1.00 106.56 ? 67  ILE R CB  1 
ATOM 402  N N   . CYS A 1 68  ? 163.853 186.901 157.736 1.00 109.09 ? 68  CYS R N   1 
ATOM 403  C CA  . CYS A 1 68  ? 163.093 188.144 157.735 1.00 109.09 ? 68  CYS R CA  1 
ATOM 404  C C   . CYS A 1 68  ? 163.321 188.971 156.477 1.00 109.09 ? 68  CYS R C   1 
ATOM 405  O O   . CYS A 1 68  ? 162.451 189.770 156.115 1.00 109.09 ? 68  CYS R O   1 
ATOM 406  C CB  . CYS A 1 68  ? 163.431 188.980 158.972 1.00 109.09 ? 68  CYS R CB  1 
ATOM 407  S SG  . CYS A 1 68  ? 165.013 189.845 158.913 1.00 109.09 ? 68  CYS R SG  1 
ATOM 408  N N   . ALA A 1 69  ? 164.462 188.808 155.806 1.00 102.38 ? 69  ALA R N   1 
ATOM 409  C CA  . ALA A 1 69  ? 164.698 189.509 154.551 1.00 102.38 ? 69  ALA R CA  1 
ATOM 410  C C   . ALA A 1 69  ? 164.081 188.809 153.349 1.00 102.38 ? 69  ALA R C   1 
ATOM 411  O O   . ALA A 1 69  ? 163.941 189.434 152.292 1.00 102.38 ? 69  ALA R O   1 
ATOM 412  C CB  . ALA A 1 69  ? 166.200 189.679 154.317 1.00 102.38 ? 69  ALA R CB  1 
ATOM 413  N N   . LEU A 1 70  ? 163.725 187.534 153.482 1.00 109.75 ? 70  LEU R N   1 
ATOM 414  C CA  . LEU A 1 70  ? 163.114 186.813 152.366 1.00 109.75 ? 70  LEU R CA  1 
ATOM 415  C C   . LEU A 1 70  ? 161.783 187.388 151.875 1.00 109.75 ? 70  LEU R C   1 
ATOM 416  O O   . LEU A 1 70  ? 161.580 187.413 150.647 1.00 109.75 ? 70  LEU R O   1 
ATOM 417  C CB  . LEU A 1 70  ? 162.951 185.334 152.745 1.00 109.75 ? 70  LEU R CB  1 
ATOM 418  N N   . PRO A 1 71  ? 160.842 187.808 152.726 1.00 108.94 ? 71  PRO R N   1 
ATOM 419  C CA  . PRO A 1 71  ? 159.515 188.215 152.226 1.00 108.94 ? 71  PRO R CA  1 
ATOM 420  C C   . PRO A 1 71  ? 159.584 189.319 151.181 1.00 108.94 ? 71  PRO R C   1 
ATOM 421  O O   . PRO A 1 71  ? 158.797 189.295 150.222 1.00 108.94 ? 71  PRO R O   1 
ATOM 422  C CB  . PRO A 1 71  ? 158.795 188.684 153.497 1.00 108.94 ? 71  PRO R CB  1 
ATOM 423  C CG  . PRO A 1 71  ? 159.342 187.807 154.533 1.00 108.94 ? 71  PRO R CG  1 
ATOM 424  C CD  . PRO A 1 71  ? 160.810 187.647 154.192 1.00 108.94 ? 71  PRO R CD  1 
ATOM 425  N N   . PRO A 1 72  ? 160.478 190.314 151.313 1.00 111.19 ? 72  PRO R N   1 
ATOM 426  C CA  . PRO A 1 72  ? 160.656 191.236 150.174 1.00 111.19 ? 72  PRO R CA  1 
ATOM 427  C C   . PRO A 1 72  ? 161.070 190.531 148.896 1.00 111.19 ? 72  PRO R C   1 
ATOM 428  O O   . PRO A 1 72  ? 160.568 190.868 147.815 1.00 111.19 ? 72  PRO R O   1 
ATOM 429  C CB  . PRO A 1 72  ? 161.741 192.206 150.658 1.00 111.19 ? 72  PRO R CB  1 
ATOM 430  C CG  . PRO A 1 72  ? 161.751 192.109 152.120 1.00 111.19 ? 72  PRO R CG  1 
ATOM 431  C CD  . PRO A 1 72  ? 161.097 190.840 152.546 1.00 111.19 ? 72  PRO R CD  1 
ATOM 432  N N   . TRP A 1 73  ? 161.960 189.540 148.993 1.00 105.95 ? 73  TRP R N   1 
ATOM 433  C CA  . TRP A 1 73  ? 162.406 188.833 147.796 1.00 105.95 ? 73  TRP R CA  1 
ATOM 434  C C   . TRP A 1 73  ? 161.282 188.022 147.168 1.00 105.95 ? 73  TRP R C   1 
ATOM 435  O O   . TRP A 1 73  ? 161.266 187.837 145.949 1.00 105.95 ? 73  TRP R O   1 
ATOM 436  C CB  . TRP A 1 73  ? 163.595 187.928 148.118 1.00 105.95 ? 73  TRP R CB  1 
ATOM 437  C CG  . TRP A 1 73  ? 164.784 188.653 148.683 1.00 105.95 ? 73  TRP R CG  1 
ATOM 438  C CD1 . TRP A 1 73  ? 165.377 188.431 149.889 1.00 105.95 ? 73  TRP R CD1 1 
ATOM 439  C CD2 . TRP A 1 73  ? 165.537 189.700 148.054 1.00 105.95 ? 73  TRP R CD2 1 
ATOM 440  N NE1 . TRP A 1 73  ? 166.441 189.282 150.059 1.00 105.95 ? 73  TRP R NE1 1 
ATOM 441  C CE2 . TRP A 1 73  ? 166.562 190.070 148.946 1.00 105.95 ? 73  TRP R CE2 1 
ATOM 442  C CE3 . TRP A 1 73  ? 165.440 190.365 146.828 1.00 105.95 ? 73  TRP R CE3 1 
ATOM 443  C CZ2 . TRP A 1 73  ? 167.483 191.072 148.651 1.00 105.95 ? 73  TRP R CZ2 1 
ATOM 444  C CZ3 . TRP A 1 73  ? 166.355 191.358 146.537 1.00 105.95 ? 73  TRP R CZ3 1 
ATOM 445  C CH2 . TRP A 1 73  ? 167.362 191.703 147.445 1.00 105.95 ? 73  TRP R CH2 1 
ATOM 446  N N   . THR A 1 74  ? 160.341 187.525 147.971 1.00 110.25 ? 74  THR R N   1 
ATOM 447  C CA  . THR A 1 74  ? 159.214 186.794 147.398 1.00 110.25 ? 74  THR R CA  1 
ATOM 448  C C   . THR A 1 74  ? 158.430 187.672 146.425 1.00 110.25 ? 74  THR R C   1 
ATOM 449  O O   . THR A 1 74  ? 158.235 187.309 145.257 1.00 110.25 ? 74  THR R O   1 
ATOM 450  C CB  . THR A 1 74  ? 158.313 186.269 148.513 1.00 110.25 ? 74  THR R CB  1 
ATOM 451  O OG1 . THR A 1 74  ? 159.009 185.248 149.237 1.00 110.25 ? 74  THR R OG1 1 
ATOM 452  C CG2 . THR A 1 74  ? 157.022 185.698 147.948 1.00 110.25 ? 74  THR R CG2 1 
ATOM 453  N N   . ASP A 1 75  ? 158.017 188.858 146.876 1.00 113.57 ? 75  ASP R N   1 
ATOM 454  C CA  . ASP A 1 75  ? 157.322 189.780 145.985 1.00 113.57 ? 75  ASP R CA  1 
ATOM 455  C C   . ASP A 1 75  ? 158.182 190.223 144.809 1.00 113.57 ? 75  ASP R C   1 
ATOM 456  O O   . ASP A 1 75  ? 157.734 190.184 143.658 1.00 113.57 ? 75  ASP R O   1 
ATOM 457  C CB  . ASP A 1 75  ? 156.824 190.996 146.767 1.00 30.00  ? 75  ASP R CB  1 
ATOM 458  C CG  . ASP A 1 75  ? 155.627 190.675 147.640 1.00 30.00  ? 75  ASP R CG  1 
ATOM 459  O OD1 . ASP A 1 75  ? 154.827 189.798 147.253 1.00 30.00  ? 75  ASP R OD1 1 
ATOM 460  O OD2 . ASP A 1 75  ? 155.487 191.296 148.713 1.00 30.00  ? 75  ASP R OD2 1 
ATOM 461  N N   . TYR A 1 76  ? 159.425 190.635 145.078 1.00 114.85 ? 76  TYR R N   1 
ATOM 462  C CA  . TYR A 1 76  ? 160.460 190.794 144.061 1.00 114.85 ? 76  TYR R CA  1 
ATOM 463  C C   . TYR A 1 76  ? 160.511 189.778 142.922 1.00 114.85 ? 76  TYR R C   1 
ATOM 464  O O   . TYR A 1 76  ? 160.549 190.152 141.743 1.00 114.85 ? 76  TYR R O   1 
ATOM 465  C CB  . TYR A 1 76  ? 161.849 190.914 144.686 1.00 114.85 ? 76  TYR R CB  1 
ATOM 466  C CG  . TYR A 1 76  ? 163.003 190.839 143.724 1.00 114.85 ? 76  TYR R CG  1 
ATOM 467  C CD1 . TYR A 1 76  ? 163.232 191.840 142.792 1.00 114.85 ? 76  TYR R CD1 1 
ATOM 468  C CD2 . TYR A 1 76  ? 163.887 189.774 143.772 1.00 114.85 ? 76  TYR R CD2 1 
ATOM 469  C CE1 . TYR A 1 76  ? 164.303 191.765 141.922 1.00 114.85 ? 76  TYR R CE1 1 
ATOM 470  C CE2 . TYR A 1 76  ? 164.951 189.690 142.912 1.00 114.85 ? 76  TYR R CE2 1 
ATOM 471  C CZ  . TYR A 1 76  ? 165.156 190.687 141.992 1.00 114.85 ? 76  TYR R CZ  1 
ATOM 472  O OH  . TYR A 1 76  ? 166.222 190.589 141.143 1.00 114.85 ? 76  TYR R OH  1 
ATOM 473  N N   . TYR A 1 77  ? 160.500 188.485 143.256 1.00 114.78 ? 77  TYR R N   1 
ATOM 474  C CA  . TYR A 1 77  ? 160.409 187.454 142.223 1.00 114.78 ? 77  TYR R CA  1 
ATOM 475  C C   . TYR A 1 77  ? 159.045 187.469 141.542 1.00 114.78 ? 77  TYR R C   1 
ATOM 476  O O   . TYR A 1 77  ? 158.961 187.416 140.309 1.00 114.78 ? 77  TYR R O   1 
ATOM 477  C CB  . TYR A 1 77  ? 160.694 186.068 142.805 1.00 30.00  ? 77  TYR R CB  1 
ATOM 478  C CG  . TYR A 1 77  ? 162.150 185.779 143.114 1.00 30.00  ? 77  TYR R CG  1 
ATOM 479  C CD1 . TYR A 1 77  ? 162.907 186.644 143.888 1.00 30.00  ? 77  TYR R CD1 1 
ATOM 480  C CD2 . TYR A 1 77  ? 162.767 184.636 142.629 1.00 30.00  ? 77  TYR R CD2 1 
ATOM 481  C CE1 . TYR A 1 77  ? 164.231 186.383 144.176 1.00 30.00  ? 77  TYR R CE1 1 
ATOM 482  C CE2 . TYR A 1 77  ? 164.095 184.370 142.907 1.00 30.00  ? 77  TYR R CE2 1 
ATOM 483  C CZ  . TYR A 1 77  ? 164.819 185.242 143.685 1.00 30.00  ? 77  TYR R CZ  1 
ATOM 484  O OH  . TYR A 1 77  ? 166.141 184.977 143.963 1.00 30.00  ? 77  TYR R OH  1 
ATOM 485  N N   . LEU A 1 78  ? 157.983 187.438 142.345 1.00 117.50 ? 78  LEU R N   1 
ATOM 486  C CA  . LEU A 1 78  ? 156.610 187.402 141.836 1.00 117.50 ? 78  LEU R CA  1 
ATOM 487  C C   . LEU A 1 78  ? 156.298 188.553 140.892 1.00 117.50 ? 78  LEU R C   1 
ATOM 488  O O   . LEU A 1 78  ? 155.295 188.541 140.179 1.00 117.50 ? 78  LEU R O   1 
ATOM 489  C CB  . LEU A 1 78  ? 155.610 187.390 142.995 1.00 30.00  ? 78  LEU R CB  1 
ATOM 490  C CG  . LEU A 1 78  ? 155.588 186.126 143.857 1.00 30.00  ? 78  LEU R CG  1 
ATOM 491  C CD1 . LEU A 1 78  ? 154.714 186.326 145.086 1.00 30.00  ? 78  LEU R CD1 1 
ATOM 492  C CD2 . LEU A 1 78  ? 155.118 184.929 143.046 1.00 30.00  ? 78  LEU R CD2 1 
ATOM 493  N N   . ARG A 1 79  ? 157.174 189.546 140.903 1.00 120.77 ? 79  ARG R N   1 
ATOM 494  C CA  . ARG A 1 79  ? 157.037 190.726 140.071 1.00 120.77 ? 79  ARG R CA  1 
ATOM 495  C C   . ARG A 1 79  ? 157.909 190.469 138.811 1.00 120.77 ? 79  ARG R C   1 
ATOM 496  O O   . ARG A 1 79  ? 158.221 191.403 138.072 1.00 120.77 ? 79  ARG R O   1 
ATOM 497  C CB  . ARG A 1 79  ? 157.562 191.954 140.801 1.00 120.77 ? 79  ARG R CB  1 
ATOM 498  C CG  . ARG A 1 79  ? 156.696 192.358 141.984 1.00 120.77 ? 79  ARG R CG  1 
ATOM 499  C CD  . ARG A 1 79  ? 155.307 192.780 141.532 1.00 120.77 ? 79  ARG R CD  1 
ATOM 500  N NE  . ARG A 1 79  ? 154.493 193.264 142.643 1.00 120.77 ? 79  ARG R NE  1 
ATOM 501  C CZ  . ARG A 1 79  ? 153.655 192.504 143.342 1.00 120.77 ? 79  ARG R CZ  1 
ATOM 502  N NH1 . ARG A 1 79  ? 152.954 193.030 144.337 1.00 120.77 ? 79  ARG R NH1 1 
ATOM 503  N NH2 . ARG A 1 79  ? 153.516 191.220 143.045 1.00 120.77 ? 79  ARG R NH2 1 
ATOM 504  N N   . ARG A 1 80  ? 158.280 189.206 138.596 1.00 119.98 ? 80  ARG R N   1 
ATOM 505  C CA  . ARG A 1 80  ? 159.083 188.806 137.428 1.00 119.98 ? 80  ARG R CA  1 
ATOM 506  C C   . ARG A 1 80  ? 160.436 189.529 137.352 1.00 119.98 ? 80  ARG R C   1 
ATOM 507  O O   . ARG A 1 80  ? 160.910 189.884 136.270 1.00 119.98 ? 80  ARG R O   1 
ATOM 508  C CB  . ARG A 1 80  ? 158.291 188.860 136.104 1.00 119.98 ? 80  ARG R CB  1 
ATOM 509  C CG  . ARG A 1 80  ? 157.317 187.709 135.908 1.00 119.98 ? 80  ARG R CG  1 
ATOM 510  C CD  . ARG A 1 80  ? 158.025 186.369 135.794 1.00 119.98 ? 80  ARG R CD  1 
ATOM 511  N NE  . ARG A 1 80  ? 158.059 185.845 134.430 1.00 119.98 ? 80  ARG R NE  1 
ATOM 512  C CZ  . ARG A 1 80  ? 158.861 184.863 134.015 1.00 119.98 ? 80  ARG R CZ  1 
ATOM 513  N NH1 . ARG A 1 80  ? 159.712 184.296 134.860 1.00 119.98 ? 80  ARG R NH1 1 
ATOM 514  N NH2 . ARG A 1 80  ? 158.825 184.452 132.749 1.00 119.98 ? 80  ARG R NH2 1 
ATOM 515  N N   . ASP A 1 81  ? 160.995 189.729 138.551 1.00 120.11 ? 81  ASP R N   1 
ATOM 516  C CA  . ASP A 1 81  ? 162.285 190.362 138.890 1.00 120.11 ? 81  ASP R CA  1 
ATOM 517  C C   . ASP A 1 81  ? 162.388 191.912 138.978 1.00 120.11 ? 81  ASP R C   1 
ATOM 518  O O   . ASP A 1 81  ? 163.437 192.426 139.370 1.00 120.11 ? 81  ASP R O   1 
ATOM 519  C CB  . ASP A 1 81  ? 163.488 189.724 138.154 1.00 120.11 ? 81  ASP R CB  1 
ATOM 520  C CG  . ASP A 1 81  ? 164.380 190.752 137.487 1.00 120.11 ? 81  ASP R CG  1 
ATOM 521  O OD1 . ASP A 1 81  ? 164.061 191.946 137.538 1.00 120.11 ? 81  ASP R OD1 1 
ATOM 522  O OD2 . ASP A 1 81  ? 165.409 190.368 136.943 1.00 120.11 ? 81  ASP R OD2 1 
ATOM 523  N N   . VAL A 1 82  ? 161.349 192.609 138.531 1.00 30.00  ? 82  VAL R N   1 
ATOM 524  C CA  . VAL A 1 82  ? 161.339 194.064 138.555 1.00 30.00  ? 82  VAL R CA  1 
ATOM 525  C C   . VAL A 1 82  ? 160.903 194.520 139.933 1.00 30.00  ? 82  VAL R C   1 
ATOM 526  O O   . VAL A 1 82  ? 159.912 194.024 140.471 1.00 30.00  ? 82  VAL R O   1 
ATOM 527  C CB  . VAL A 1 82  ? 160.384 194.645 137.498 1.00 30.00  ? 82  VAL R CB  1 
ATOM 528  C CG1 . VAL A 1 82  ? 158.950 194.610 138.003 1.00 30.00  ? 82  VAL R CG1 1 
ATOM 529  C CG2 . VAL A 1 82  ? 160.794 196.065 137.137 1.00 30.00  ? 82  VAL R CG2 1 
ATOM 530  N N   . TRP A 1 83  ? 161.637 195.462 140.512 1.00 122.65 ? 83  TRP R N   1 
ATOM 531  C CA  . TRP A 1 83  ? 161.287 195.925 141.839 1.00 122.65 ? 83  TRP R CA  1 
ATOM 532  C C   . TRP A 1 83  ? 159.951 196.643 141.992 1.00 122.65 ? 83  TRP R C   1 
ATOM 533  O O   . TRP A 1 83  ? 159.593 197.500 141.187 1.00 122.65 ? 83  TRP R O   1 
ATOM 534  C CB  . TRP A 1 83  ? 162.390 196.814 142.390 1.00 30.00  ? 83  TRP R CB  1 
ATOM 535  C CG  . TRP A 1 83  ? 162.450 196.649 143.822 1.00 30.00  ? 83  TRP R CG  1 
ATOM 536  C CD1 . TRP A 1 83  ? 161.763 197.339 144.742 1.00 30.00  ? 83  TRP R CD1 1 
ATOM 537  C CD2 . TRP A 1 83  ? 163.187 195.661 144.520 1.00 30.00  ? 83  TRP R CD2 1 
ATOM 538  N NE1 . TRP A 1 83  ? 162.047 196.876 145.994 1.00 30.00  ? 83  TRP R NE1 1 
ATOM 539  C CE2 . TRP A 1 83  ? 162.928 195.836 145.880 1.00 30.00  ? 83  TRP R CE2 1 
ATOM 540  C CE3 . TRP A 1 83  ? 164.059 194.652 144.124 1.00 30.00  ? 83  TRP R CE3 1 
ATOM 541  C CZ2 . TRP A 1 83  ? 163.484 195.037 146.843 1.00 30.00  ? 83  TRP R CZ2 1 
ATOM 542  C CZ3 . TRP A 1 83  ? 164.622 193.877 145.079 1.00 30.00  ? 83  TRP R CZ3 1 
ATOM 543  C CH2 . TRP A 1 83  ? 164.341 194.077 146.429 1.00 30.00  ? 83  TRP R CH2 1 
ATOM 544  N N   . GLY A 1 84  ? 159.215 196.268 143.035 1.00 121.31 ? 84  GLY R N   1 
ATOM 545  C CA  . GLY A 1 84  ? 157.946 196.899 143.350 1.00 121.31 ? 84  GLY R CA  1 
ATOM 546  C C   . GLY A 1 84  ? 157.841 197.469 144.758 1.00 121.31 ? 84  GLY R C   1 
ATOM 547  O O   . GLY A 1 84  ? 157.051 198.377 145.007 1.00 121.31 ? 84  GLY R O   1 
ATOM 548  N N   . TYR A 1 85  ? 158.611 196.906 145.688 1.00 125.45 ? 85  TYR R N   1 
ATOM 549  C CA  . TYR A 1 85  ? 158.572 197.334 147.093 1.00 125.45 ? 85  TYR R CA  1 
ATOM 550  C C   . TYR A 1 85  ? 159.032 198.749 147.434 1.00 125.45 ? 85  TYR R C   1 
ATOM 551  O O   . TYR A 1 85  ? 158.361 199.455 148.181 1.00 125.45 ? 85  TYR R O   1 
ATOM 552  C CB  . TYR A 1 85  ? 159.339 196.340 147.968 1.00 125.45 ? 85  TYR R CB  1 
ATOM 553  N N   . GLY A 1 86  ? 160.162 199.172 146.888 1.00 121.46 ? 86  GLY R N   1 
ATOM 554  C CA  . GLY A 1 86  ? 160.666 200.500 147.175 1.00 121.46 ? 86  GLY R CA  1 
ATOM 555  C C   . GLY A 1 86  ? 161.420 201.157 146.037 1.00 121.46 ? 86  GLY R C   1 
ATOM 556  O O   . GLY A 1 86  ? 162.088 200.489 145.255 1.00 121.46 ? 86  GLY R O   1 
ATOM 557  N N   . PRO A 1 87  ? 161.320 202.488 145.935 1.00 117.80 ? 87  PRO R N   1 
ATOM 558  C CA  . PRO A 1 87  ? 162.086 203.095 144.848 1.00 117.80 ? 87  PRO R CA  1 
ATOM 559  C C   . PRO A 1 87  ? 163.578 202.897 145.072 1.00 117.80 ? 87  PRO R C   1 
ATOM 560  O O   . PRO A 1 87  ? 164.293 202.509 144.154 1.00 117.80 ? 87  PRO R O   1 
ATOM 561  C CB  . PRO A 1 87  ? 161.723 204.580 144.949 1.00 117.80 ? 87  PRO R CB  1 
ATOM 562  C CG  . PRO A 1 87  ? 161.224 204.774 146.345 1.00 117.80 ? 87  PRO R CG  1 
ATOM 563  C CD  . PRO A 1 87  ? 160.590 203.478 146.745 1.00 117.80 ? 87  PRO R CD  1 
ATOM 564  N N   . GLY A 1 88  ? 164.035 203.145 146.292 1.00 115.11 ? 88  GLY R N   1 
ATOM 565  C CA  . GLY A 1 88  ? 165.437 202.992 146.622 1.00 115.11 ? 88  GLY R CA  1 
ATOM 566  C C   . GLY A 1 88  ? 165.745 202.137 147.825 1.00 115.11 ? 88  GLY R C   1 
ATOM 567  O O   . GLY A 1 88  ? 166.898 201.867 148.107 1.00 115.11 ? 88  GLY R O   1 
ATOM 568  N N   . ALA A 1 89  ? 164.709 201.705 148.543 1.00 113.36 ? 89  ALA R N   1 
ATOM 569  C CA  . ALA A 1 89  ? 164.863 200.918 149.779 1.00 113.36 ? 89  ALA R CA  1 
ATOM 570  C C   . ALA A 1 89  ? 165.421 199.488 149.679 1.00 113.36 ? 89  ALA R C   1 
ATOM 571  O O   . ALA A 1 89  ? 165.568 198.808 150.694 1.00 113.36 ? 89  ALA R O   1 
ATOM 572  C CB  . ALA A 1 89  ? 163.550 200.911 150.555 1.00 113.36 ? 89  ALA R CB  1 
ATOM 573  N N   . CYS A 1 90  ? 165.730 199.040 148.470 1.00 110.62 ? 90  CYS R N   1 
ATOM 574  C CA  . CYS A 1 90  ? 166.265 197.702 148.237 1.00 110.62 ? 90  CYS R CA  1 
ATOM 575  C C   . CYS A 1 90  ? 167.722 197.457 148.633 1.00 110.62 ? 90  CYS R C   1 
ATOM 576  O O   . CYS A 1 90  ? 168.098 196.307 148.868 1.00 110.62 ? 90  CYS R O   1 
ATOM 577  C CB  . CYS A 1 90  ? 165.972 197.237 146.808 1.00 110.62 ? 90  CYS R CB  1 
ATOM 578  S SG  . CYS A 1 90  ? 166.880 198.107 145.520 1.00 110.62 ? 90  CYS R SG  1 
ATOM 579  N N   . ARG A 1 91  ? 168.543 198.506 148.670 1.00 108.54 ? 91  ARG R N   1 
ATOM 580  C CA  . ARG A 1 91  ? 169.916 198.345 149.127 1.00 108.54 ? 91  ARG R CA  1 
ATOM 581  C C   . ARG A 1 91  ? 169.959 197.687 150.496 1.00 108.54 ? 91  ARG R C   1 
ATOM 582  O O   . ARG A 1 91  ? 170.815 196.839 150.755 1.00 108.54 ? 91  ARG R O   1 
ATOM 583  C CB  . ARG A 1 91  ? 170.624 199.701 149.154 1.00 30.00  ? 91  ARG R CB  1 
ATOM 584  N N   . LEU A 1 92  ? 169.023 198.045 151.378 1.00 109.14 ? 92  LEU R N   1 
ATOM 585  C CA  . LEU A 1 92  ? 168.971 197.429 152.702 1.00 109.14 ? 92  LEU R CA  1 
ATOM 586  C C   . LEU A 1 92  ? 168.752 195.921 152.602 1.00 109.14 ? 92  LEU R C   1 
ATOM 587  O O   . LEU A 1 92  ? 169.425 195.136 153.283 1.00 109.14 ? 92  LEU R O   1 
ATOM 588  C CB  . LEU A 1 92  ? 167.868 198.087 153.535 1.00 109.14 ? 92  LEU R CB  1 
ATOM 589  C CG  . LEU A 1 92  ? 167.754 197.758 155.028 1.00 109.14 ? 92  LEU R CG  1 
ATOM 590  C CD1 . LEU A 1 92  ? 167.169 198.945 155.777 1.00 109.14 ? 92  LEU R CD1 1 
ATOM 591  C CD2 . LEU A 1 92  ? 166.905 196.518 155.275 1.00 109.14 ? 92  LEU R CD2 1 
ATOM 592  N N   . PHE A 1 93  ? 167.812 195.498 151.752 1.00 101.34 ? 93  PHE R N   1 
ATOM 593  C CA  . PHE A 1 93  ? 167.480 194.079 151.668 1.00 101.34 ? 93  PHE R CA  1 
ATOM 594  C C   . PHE A 1 93  ? 168.600 193.281 151.008 1.00 101.34 ? 93  PHE R C   1 
ATOM 595  O O   . PHE A 1 93  ? 168.950 192.189 151.475 1.00 101.34 ? 93  PHE R O   1 
ATOM 596  C CB  . PHE A 1 93  ? 166.159 193.905 150.927 1.00 101.34 ? 93  PHE R CB  1 
ATOM 597  C CG  . PHE A 1 93  ? 164.998 194.560 151.619 1.00 101.34 ? 93  PHE R CG  1 
ATOM 598  C CD1 . PHE A 1 93  ? 164.580 194.119 152.862 1.00 101.34 ? 93  PHE R CD1 1 
ATOM 599  C CD2 . PHE A 1 93  ? 164.335 195.625 151.034 1.00 101.34 ? 93  PHE R CD2 1 
ATOM 600  C CE1 . PHE A 1 93  ? 163.523 194.725 153.507 1.00 101.34 ? 93  PHE R CE1 1 
ATOM 601  C CE2 . PHE A 1 93  ? 163.271 196.231 151.675 1.00 101.34 ? 93  PHE R CE2 1 
ATOM 602  C CZ  . PHE A 1 93  ? 162.866 195.780 152.912 1.00 101.34 ? 93  PHE R CZ  1 
ATOM 603  N N   . GLY A 1 94  ? 169.193 193.818 149.941 1.00 100.79 ? 94  GLY R N   1 
ATOM 604  C CA  . GLY A 1 94  ? 170.365 193.173 149.369 1.00 100.79 ? 94  GLY R CA  1 
ATOM 605  C C   . GLY A 1 94  ? 171.512 193.081 150.358 1.00 100.79 ? 94  GLY R C   1 
ATOM 606  O O   . GLY A 1 94  ? 172.189 192.049 150.451 1.00 100.79 ? 94  GLY R O   1 
ATOM 607  N N   . PHE A 1 95  ? 171.731 194.153 151.123 1.00 101.56 ? 95  PHE R N   1 
ATOM 608  C CA  . PHE A 1 95  ? 172.780 194.173 152.134 1.00 101.56 ? 95  PHE R CA  1 
ATOM 609  C C   . PHE A 1 95  ? 172.582 193.072 153.160 1.00 101.56 ? 95  PHE R C   1 
ATOM 610  O O   . PHE A 1 95  ? 173.501 192.291 153.431 1.00 101.56 ? 95  PHE R O   1 
ATOM 611  C CB  . PHE A 1 95  ? 172.796 195.538 152.819 1.00 101.56 ? 95  PHE R CB  1 
ATOM 612  C CG  . PHE A 1 95  ? 174.037 195.810 153.609 1.00 101.56 ? 95  PHE R CG  1 
ATOM 613  C CD1 . PHE A 1 95  ? 175.247 196.023 152.980 1.00 101.56 ? 95  PHE R CD1 1 
ATOM 614  C CD2 . PHE A 1 95  ? 173.986 195.864 154.991 1.00 101.56 ? 95  PHE R CD2 1 
ATOM 615  C CE1 . PHE A 1 95  ? 176.382 196.275 153.714 1.00 101.56 ? 95  PHE R CE1 1 
ATOM 616  C CE2 . PHE A 1 95  ? 175.120 196.117 155.729 1.00 101.56 ? 95  PHE R CE2 1 
ATOM 617  C CZ  . PHE A 1 95  ? 176.321 196.323 155.089 1.00 101.56 ? 95  PHE R CZ  1 
ATOM 618  N N   . VAL A 1 96  ? 171.387 192.997 153.750 1.00 97.82  ? 96  VAL R N   1 
ATOM 619  C CA  . VAL A 1 96  ? 171.166 191.995 154.787 1.00 97.82  ? 96  VAL R CA  1 
ATOM 620  C C   . VAL A 1 96  ? 171.291 190.593 154.203 1.00 97.82  ? 96  VAL R C   1 
ATOM 621  O O   . VAL A 1 96  ? 171.955 189.728 154.786 1.00 97.82  ? 96  VAL R O   1 
ATOM 622  C CB  . VAL A 1 96  ? 169.817 192.213 155.502 1.00 97.82  ? 96  VAL R CB  1 
ATOM 623  C CG1 . VAL A 1 96  ? 169.865 193.478 156.345 1.00 97.82  ? 96  VAL R CG1 1 
ATOM 624  C CG2 . VAL A 1 96  ? 168.672 192.277 154.526 1.00 97.82  ? 96  VAL R CG2 1 
ATOM 625  N N   . PHE A 1 97  ? 170.703 190.356 153.024 1.00 92.54  ? 97  PHE R N   1 
ATOM 626  C CA  . PHE A 1 97  ? 170.783 189.028 152.421 1.00 92.54  ? 97  PHE R CA  1 
ATOM 627  C C   . PHE A 1 97  ? 172.232 188.591 152.226 1.00 92.54  ? 97  PHE R C   1 
ATOM 628  O O   . PHE A 1 97  ? 172.638 187.521 152.700 1.00 92.54  ? 97  PHE R O   1 
ATOM 629  C CB  . PHE A 1 97  ? 170.032 189.013 151.090 1.00 92.54  ? 97  PHE R CB  1 
ATOM 630  C CG  . PHE A 1 97  ? 169.780 187.633 150.548 1.00 92.54  ? 97  PHE R CG  1 
ATOM 631  C CD1 . PHE A 1 97  ? 168.583 186.986 150.798 1.00 92.54  ? 97  PHE R CD1 1 
ATOM 632  C CD2 . PHE A 1 97  ? 170.734 186.991 149.779 1.00 92.54  ? 97  PHE R CD2 1 
ATOM 633  C CE1 . PHE A 1 97  ? 168.347 185.720 150.299 1.00 92.54  ? 97  PHE R CE1 1 
ATOM 634  C CE2 . PHE A 1 97  ? 170.504 185.725 149.278 1.00 92.54  ? 97  PHE R CE2 1 
ATOM 635  C CZ  . PHE A 1 97  ? 169.309 185.090 149.537 1.00 92.54  ? 97  PHE R CZ  1 
ATOM 636  N N   . TYR A 1 98  ? 173.041 189.422 151.563 1.00 90.74  ? 98  TYR R N   1 
ATOM 637  C CA  . TYR A 1 98  ? 174.397 188.993 151.231 1.00 90.74  ? 98  TYR R CA  1 
ATOM 638  C C   . TYR A 1 98  ? 175.288 188.930 152.469 1.00 90.74  ? 98  TYR R C   1 
ATOM 639  O O   . TYR A 1 98  ? 176.109 188.007 152.610 1.00 90.74  ? 98  TYR R O   1 
ATOM 640  C CB  . TYR A 1 98  ? 174.992 189.919 150.172 1.00 90.74  ? 98  TYR R CB  1 
ATOM 641  C CG  . TYR A 1 98  ? 174.313 189.803 148.824 1.00 90.74  ? 98  TYR R CG  1 
ATOM 642  C CD1 . TYR A 1 98  ? 173.569 188.680 148.495 1.00 90.74  ? 98  TYR R CD1 1 
ATOM 643  C CD2 . TYR A 1 98  ? 174.416 190.817 147.883 1.00 90.74  ? 98  TYR R CD2 1 
ATOM 644  C CE1 . TYR A 1 98  ? 172.946 188.568 147.267 1.00 90.74  ? 98  TYR R CE1 1 
ATOM 645  C CE2 . TYR A 1 98  ? 173.797 190.713 146.651 1.00 90.74  ? 98  TYR R CE2 1 
ATOM 646  C CZ  . TYR A 1 98  ? 173.062 189.587 146.350 1.00 90.74  ? 98  TYR R CZ  1 
ATOM 647  O OH  . TYR A 1 98  ? 172.444 189.477 145.126 1.00 90.74  ? 98  TYR R OH  1 
ATOM 648  N N   . THR A 1 99  ? 175.138 189.890 153.386 1.00 93.08  ? 99  THR R N   1 
ATOM 649  C CA  . THR A 1 99  ? 175.956 189.873 154.590 1.00 93.08  ? 99  THR R CA  1 
ATOM 650  C C   . THR A 1 99  ? 175.653 188.648 155.441 1.00 93.08  ? 99  THR R C   1 
ATOM 651  O O   . THR A 1 99  ? 176.572 188.032 155.989 1.00 93.08  ? 99  THR R O   1 
ATOM 652  C CB  . THR A 1 99  ? 175.742 191.155 155.391 1.00 93.08  ? 99  THR R CB  1 
ATOM 653  O OG1 . THR A 1 99  ? 175.879 192.287 154.524 1.00 93.08  ? 99  THR R OG1 1 
ATOM 654  C CG2 . THR A 1 99  ? 176.767 191.258 156.510 1.00 93.08  ? 99  THR R CG2 1 
ATOM 655  N N   . ASN A 1 100 ? 174.378 188.265 155.553 1.00 90.43  ? 100 ASN R N   1 
ATOM 656  C CA  . ASN A 1 100 ? 174.046 187.029 156.253 1.00 90.43  ? 100 ASN R CA  1 
ATOM 657  C C   . ASN A 1 100 ? 174.609 185.819 155.523 1.00 90.43  ? 100 ASN R C   1 
ATOM 658  O O   . ASN A 1 100 ? 175.094 184.872 156.155 1.00 90.43  ? 100 ASN R O   1 
ATOM 659  C CB  . ASN A 1 100 ? 172.536 186.898 156.396 1.00 30.00  ? 100 ASN R CB  1 
ATOM 660  C CG  . ASN A 1 100 ? 171.927 188.028 157.179 1.00 30.00  ? 100 ASN R CG  1 
ATOM 661  O OD1 . ASN A 1 100 ? 170.810 188.451 156.892 1.00 30.00  ? 100 ASN R OD1 1 
ATOM 662  N ND2 . ASN A 1 100 ? 172.652 188.527 158.172 1.00 30.00  ? 100 ASN R ND2 1 
ATOM 663  N N   . LEU A 1 101 ? 174.535 185.827 154.188 1.00 85.89  ? 101 LEU R N   1 
ATOM 664  C CA  . LEU A 1 101 ? 175.080 184.729 153.398 1.00 85.89  ? 101 LEU R CA  1 
ATOM 665  C C   . LEU A 1 101 ? 176.549 184.490 153.722 1.00 85.89  ? 101 LEU R C   1 
ATOM 666  O O   . LEU A 1 101 ? 177.003 183.341 153.782 1.00 85.89  ? 101 LEU R O   1 
ATOM 667  C CB  . LEU A 1 101 ? 174.901 185.031 151.909 1.00 85.89  ? 101 LEU R CB  1 
ATOM 668  C CG  . LEU A 1 101 ? 175.348 183.977 150.900 1.00 85.89  ? 101 LEU R CG  1 
ATOM 669  C CD1 . LEU A 1 101 ? 174.541 182.709 151.076 1.00 85.89  ? 101 LEU R CD1 1 
ATOM 670  C CD2 . LEU A 1 101 ? 175.208 184.509 149.487 1.00 85.89  ? 101 LEU R CD2 1 
ATOM 671  N N   . TYR A 1 102 ? 177.309 185.564 153.931 1.00 89.56  ? 102 TYR R N   1 
ATOM 672  C CA  . TYR A 1 102 ? 178.722 185.396 154.272 1.00 89.56  ? 102 TYR R CA  1 
ATOM 673  C C   . TYR A 1 102 ? 178.928 185.077 155.756 1.00 89.56  ? 102 TYR R C   1 
ATOM 674  O O   . TYR A 1 102 ? 179.777 184.241 156.112 1.00 89.56  ? 102 TYR R O   1 
ATOM 675  C CB  . TYR A 1 102 ? 179.500 186.650 153.877 1.00 89.56  ? 102 TYR R CB  1 
ATOM 676  C CG  . TYR A 1 102 ? 179.426 186.966 152.399 1.00 89.56  ? 102 TYR R CG  1 
ATOM 677  C CD1 . TYR A 1 102 ? 179.243 185.958 151.461 1.00 89.56  ? 102 TYR R CD1 1 
ATOM 678  C CD2 . TYR A 1 102 ? 179.535 188.271 151.942 1.00 89.56  ? 102 TYR R CD2 1 
ATOM 679  C CE1 . TYR A 1 102 ? 179.172 186.242 150.110 1.00 89.56  ? 102 TYR R CE1 1 
ATOM 680  C CE2 . TYR A 1 102 ? 179.466 188.564 150.593 1.00 89.56  ? 102 TYR R CE2 1 
ATOM 681  C CZ  . TYR A 1 102 ? 179.284 187.546 149.682 1.00 89.56  ? 102 TYR R CZ  1 
ATOM 682  O OH  . TYR A 1 102 ? 179.214 187.833 148.339 1.00 89.56  ? 102 TYR R OH  1 
ATOM 683  N N   . VAL A 1 103 ? 178.156 185.724 156.631 1.00 83.30  ? 103 VAL R N   1 
ATOM 684  C CA  . VAL A 1 103 ? 178.348 185.583 158.071 1.00 83.30  ? 103 VAL R CA  1 
ATOM 685  C C   . VAL A 1 103 ? 178.019 184.167 158.529 1.00 83.30  ? 103 VAL R C   1 
ATOM 686  O O   . VAL A 1 103 ? 178.654 183.633 159.449 1.00 83.30  ? 103 VAL R O   1 
ATOM 687  C CB  . VAL A 1 103 ? 177.507 186.641 158.811 1.00 83.30  ? 103 VAL R CB  1 
ATOM 688  C CG1 . VAL A 1 103 ? 177.342 186.287 160.265 1.00 83.30  ? 103 VAL R CG1 1 
ATOM 689  C CG2 . VAL A 1 103 ? 178.155 188.003 158.687 1.00 83.30  ? 103 VAL R CG2 1 
ATOM 690  N N   . GLY A 1 104 ? 177.020 183.538 157.906 1.00 83.61  ? 104 GLY R N   1 
ATOM 691  C CA  . GLY A 1 104 ? 176.699 182.165 158.260 1.00 83.61  ? 104 GLY R CA  1 
ATOM 692  C C   . GLY A 1 104 ? 177.865 181.223 158.037 1.00 83.61  ? 104 GLY R C   1 
ATOM 693  O O   . GLY A 1 104 ? 178.186 180.394 158.893 1.00 83.61  ? 104 GLY R O   1 
ATOM 694  N N   . ALA A 1 105 ? 178.522 181.342 156.882 1.00 79.78  ? 105 ALA R N   1 
ATOM 695  C CA  . ALA A 1 105 ? 179.698 180.524 156.615 1.00 79.78  ? 105 ALA R CA  1 
ATOM 696  C C   . ALA A 1 105 ? 180.824 180.849 157.587 1.00 79.78  ? 105 ALA R C   1 
ATOM 697  O O   . ALA A 1 105 ? 181.538 179.947 158.049 1.00 79.78  ? 105 ALA R O   1 
ATOM 698  C CB  . ALA A 1 105 ? 180.158 180.721 155.171 1.00 79.78  ? 105 ALA R CB  1 
ATOM 699  N N   . ALA A 1 106 ? 181.002 182.134 157.911 1.00 78.82  ? 106 ALA R N   1 
ATOM 700  C CA  . ALA A 1 106 ? 182.058 182.500 158.852 1.00 78.82  ? 106 ALA R CA  1 
ATOM 701  C C   . ALA A 1 106 ? 181.842 181.843 160.211 1.00 78.82  ? 106 ALA R C   1 
ATOM 702  O O   . ALA A 1 106 ? 182.784 181.315 160.819 1.00 78.82  ? 106 ALA R O   1 
ATOM 703  C CB  . ALA A 1 106 ? 182.133 184.019 158.994 1.00 78.82  ? 106 ALA R CB  1 
ATOM 704  N N   . PHE A 1 107 ? 180.602 181.838 160.697 1.00 79.81  ? 107 PHE R N   1 
ATOM 705  C CA  . PHE A 1 107 ? 180.349 181.246 162.006 1.00 79.81  ? 107 PHE R CA  1 
ATOM 706  C C   . PHE A 1 107 ? 180.321 179.723 161.956 1.00 79.81  ? 107 PHE R C   1 
ATOM 707  O O   . PHE A 1 107 ? 180.626 179.075 162.963 1.00 79.81  ? 107 PHE R O   1 
ATOM 708  C CB  . PHE A 1 107 ? 179.062 181.812 162.601 1.00 79.81  ? 107 PHE R CB  1 
ATOM 709  C CG  . PHE A 1 107 ? 179.245 183.168 163.215 1.00 79.81  ? 107 PHE R CG  1 
ATOM 710  C CD1 . PHE A 1 107 ? 180.163 183.357 164.234 1.00 79.81  ? 107 PHE R CD1 1 
ATOM 711  C CD2 . PHE A 1 107 ? 178.533 184.257 162.755 1.00 79.81  ? 107 PHE R CD2 1 
ATOM 712  C CE1 . PHE A 1 107 ? 180.350 184.603 164.794 1.00 79.81  ? 107 PHE R CE1 1 
ATOM 713  C CE2 . PHE A 1 107 ? 178.720 185.507 163.309 1.00 79.81  ? 107 PHE R CE2 1 
ATOM 714  C CZ  . PHE A 1 107 ? 179.629 185.679 164.330 1.00 79.81  ? 107 PHE R CZ  1 
ATOM 715  N N   . LEU A 1 108 ? 179.993 179.133 160.804 1.00 76.00  ? 108 LEU R N   1 
ATOM 716  C CA  . LEU A 1 108 ? 180.206 177.699 160.632 1.00 76.00  ? 108 LEU R CA  1 
ATOM 717  C C   . LEU A 1 108 ? 181.681 177.359 160.796 1.00 76.00  ? 108 LEU R C   1 
ATOM 718  O O   . LEU A 1 108 ? 182.045 176.397 161.488 1.00 76.00  ? 108 LEU R O   1 
ATOM 719  C CB  . LEU A 1 108 ? 179.709 177.257 159.256 1.00 76.00  ? 108 LEU R CB  1 
ATOM 720  C CG  . LEU A 1 108 ? 178.206 177.104 159.038 1.00 76.00  ? 108 LEU R CG  1 
ATOM 721  C CD1 . LEU A 1 108 ? 177.882 177.123 157.555 1.00 76.00  ? 108 LEU R CD1 1 
ATOM 722  C CD2 . LEU A 1 108 ? 177.710 175.826 159.672 1.00 76.00  ? 108 LEU R CD2 1 
ATOM 723  N N   . SER A 1 109 ? 182.547 178.162 160.171 1.00 76.10  ? 109 SER R N   1 
ATOM 724  C CA  . SER A 1 109 ? 183.986 177.974 160.314 1.00 76.10  ? 109 SER R CA  1 
ATOM 725  C C   . SER A 1 109 ? 184.422 178.125 161.765 1.00 76.10  ? 109 SER R C   1 
ATOM 726  O O   . SER A 1 109 ? 185.261 177.358 162.255 1.00 76.10  ? 109 SER R O   1 
ATOM 727  C CB  . SER A 1 109 ? 184.723 178.970 159.421 1.00 76.10  ? 109 SER R CB  1 
ATOM 728  O OG  . SER A 1 109 ? 186.117 178.938 159.657 1.00 76.10  ? 109 SER R OG  1 
ATOM 729  N N   . CYS A 1 110 ? 183.868 179.116 162.466 1.00 76.69  ? 110 CYS R N   1 
ATOM 730  C CA  . CYS A 1 110 ? 184.219 179.316 163.871 1.00 76.69  ? 110 CYS R CA  1 
ATOM 731  C C   . CYS A 1 110 ? 183.795 178.131 164.734 1.00 76.69  ? 110 CYS R C   1 
ATOM 732  O O   . CYS A 1 110 ? 184.538 177.705 165.626 1.00 76.69  ? 110 CYS R O   1 
ATOM 733  C CB  . CYS A 1 110 ? 183.599 180.610 164.390 1.00 76.69  ? 110 CYS R CB  1 
ATOM 734  S SG  . CYS A 1 110 ? 184.536 182.064 163.929 1.00 76.69  ? 110 CYS R SG  1 
ATOM 735  N N   . VAL A 1 111 ? 182.594 177.598 164.499 1.00 73.79  ? 111 VAL R N   1 
ATOM 736  C CA  . VAL A 1 111 ? 182.139 176.434 165.257 1.00 73.79  ? 111 VAL R CA  1 
ATOM 737  C C   . VAL A 1 111 ? 183.058 175.246 165.003 1.00 73.79  ? 111 VAL R C   1 
ATOM 738  O O   . VAL A 1 111 ? 183.432 174.516 165.933 1.00 73.79  ? 111 VAL R O   1 
ATOM 739  C CB  . VAL A 1 111 ? 180.675 176.104 164.908 1.00 73.79  ? 111 VAL R CB  1 
ATOM 740  C CG1 . VAL A 1 111 ? 180.350 174.658 165.245 1.00 73.79  ? 111 VAL R CG1 1 
ATOM 741  C CG2 . VAL A 1 111 ? 179.730 177.044 165.631 1.00 73.79  ? 111 VAL R CG2 1 
ATOM 742  N N   . SER A 1 112 ? 183.439 175.036 163.740 1.00 74.43  ? 112 SER R N   1 
ATOM 743  C CA  . SER A 1 112 ? 184.345 173.937 163.420 1.00 74.43  ? 112 SER R CA  1 
ATOM 744  C C   . SER A 1 112 ? 185.691 174.110 164.113 1.00 74.43  ? 112 SER R C   1 
ATOM 745  O O   . SER A 1 112 ? 186.253 173.145 164.644 1.00 74.43  ? 112 SER R O   1 
ATOM 746  C CB  . SER A 1 112 ? 184.528 173.835 161.907 1.00 74.43  ? 112 SER R CB  1 
ATOM 747  O OG  . SER A 1 112 ? 185.337 172.723 161.568 1.00 74.43  ? 112 SER R OG  1 
ATOM 748  N N   . ALA A 1 113 ? 186.224 175.334 164.119 1.00 74.15  ? 113 ALA R N   1 
ATOM 749  C CA  . ALA A 1 113 ? 187.501 175.583 164.783 1.00 74.15  ? 113 ALA R CA  1 
ATOM 750  C C   . ALA A 1 113 ? 187.398 175.354 166.286 1.00 74.15  ? 113 ALA R C   1 
ATOM 751  O O   . ALA A 1 113 ? 188.319 174.802 166.901 1.00 74.15  ? 113 ALA R O   1 
ATOM 752  C CB  . ALA A 1 113 ? 187.980 177.003 164.487 1.00 74.15  ? 113 ALA R CB  1 
ATOM 753  N N   . ASP A 1 114 ? 186.289 175.779 166.895 1.00 78.18  ? 114 ASP R N   1 
ATOM 754  C CA  . ASP A 1 114 ? 186.096 175.555 168.323 1.00 78.18  ? 114 ASP R CA  1 
ATOM 755  C C   . ASP A 1 114 ? 186.054 174.068 168.645 1.00 78.18  ? 114 ASP R C   1 
ATOM 756  O O   . ASP A 1 114 ? 186.681 173.616 169.611 1.00 78.18  ? 114 ASP R O   1 
ATOM 757  C CB  . ASP A 1 114 ? 184.816 176.244 168.791 1.00 78.18  ? 114 ASP R CB  1 
ATOM 758  C CG  . ASP A 1 114 ? 184.709 176.307 170.298 1.00 78.18  ? 114 ASP R CG  1 
ATOM 759  O OD1 . ASP A 1 114 ? 185.638 176.846 170.934 1.00 78.18  ? 114 ASP R OD1 1 
ATOM 760  O OD2 . ASP A 1 114 ? 183.701 175.818 170.848 1.00 78.18  ? 114 ASP R OD2 1 
ATOM 761  N N   . ARG A 1 115 ? 185.327 173.290 167.841 1.00 79.48  ? 115 ARG R N   1 
ATOM 762  C CA  . ARG A 1 115 ? 185.292 171.847 168.058 1.00 79.48  ? 115 ARG R CA  1 
ATOM 763  C C   . ARG A 1 115 ? 186.673 171.230 167.882 1.00 79.48  ? 115 ARG R C   1 
ATOM 764  O O   . ARG A 1 115 ? 187.071 170.345 168.652 1.00 79.48  ? 115 ARG R O   1 
ATOM 765  C CB  . ARG A 1 115 ? 184.289 171.194 167.110 1.00 79.48  ? 115 ARG R CB  1 
ATOM 766  C CG  . ARG A 1 115 ? 182.841 171.513 167.416 1.00 79.48  ? 115 ARG R CG  1 
ATOM 767  C CD  . ARG A 1 115 ? 181.917 170.750 166.486 1.00 79.48  ? 115 ARG R CD  1 
ATOM 768  N NE  . ARG A 1 115 ? 180.549 170.703 166.989 1.00 79.48  ? 115 ARG R NE  1 
ATOM 769  C CZ  . ARG A 1 115 ? 179.473 170.659 166.213 1.00 79.48  ? 115 ARG R CZ  1 
ATOM 770  N NH1 . ARG A 1 115 ? 179.607 170.655 164.895 1.00 79.48  ? 115 ARG R NH1 1 
ATOM 771  N NH2 . ARG A 1 115 ? 178.264 170.620 166.753 1.00 79.48  ? 115 ARG R NH2 1 
ATOM 772  N N   . TYR A 1 116 ? 187.421 171.683 166.871 1.00 76.38  ? 116 TYR R N   1 
ATOM 773  C CA  . TYR A 1 116 ? 188.756 171.142 166.647 1.00 76.38  ? 116 TYR R CA  1 
ATOM 774  C C   . TYR A 1 116 ? 189.669 171.416 167.832 1.00 76.38  ? 116 TYR R C   1 
ATOM 775  O O   . TYR A 1 116 ? 190.429 170.539 168.254 1.00 76.38  ? 116 TYR R O   1 
ATOM 776  C CB  . TYR A 1 116 ? 189.373 171.727 165.381 1.00 76.38  ? 116 TYR R CB  1 
ATOM 777  C CG  . TYR A 1 116 ? 190.854 171.455 165.291 1.00 76.38  ? 116 TYR R CG  1 
ATOM 778  C CD1 . TYR A 1 116 ? 191.332 170.160 165.176 1.00 76.38  ? 116 TYR R CD1 1 
ATOM 779  C CD2 . TYR A 1 116 ? 191.776 172.485 165.359 1.00 76.38  ? 116 TYR R CD2 1 
ATOM 780  C CE1 . TYR A 1 116 ? 192.680 169.901 165.104 1.00 76.38  ? 116 TYR R CE1 1 
ATOM 781  C CE2 . TYR A 1 116 ? 193.128 172.233 165.293 1.00 76.38  ? 116 TYR R CE2 1 
ATOM 782  C CZ  . TYR A 1 116 ? 193.572 170.938 165.168 1.00 76.38  ? 116 TYR R CZ  1 
ATOM 783  O OH  . TYR A 1 116 ? 194.919 170.681 165.098 1.00 76.38  ? 116 TYR R OH  1 
ATOM 784  N N   . LEU A 1 117 ? 189.619 172.631 168.376 1.00 74.71  ? 117 LEU R N   1 
ATOM 785  C CA  . LEU A 1 117 ? 190.478 172.947 169.511 1.00 74.71  ? 117 LEU R CA  1 
ATOM 786  C C   . LEU A 1 117 ? 190.015 172.242 170.778 1.00 74.71  ? 117 LEU R C   1 
ATOM 787  O O   . LEU A 1 117 ? 190.835 171.945 171.654 1.00 74.71  ? 117 LEU R O   1 
ATOM 788  C CB  . LEU A 1 117 ? 190.537 174.458 169.727 1.00 74.71  ? 117 LEU R CB  1 
ATOM 789  C CG  . LEU A 1 117 ? 191.029 175.266 168.529 1.00 74.71  ? 117 LEU R CG  1 
ATOM 790  C CD1 . LEU A 1 117 ? 190.472 176.676 168.566 1.00 74.71  ? 117 LEU R CD1 1 
ATOM 791  C CD2 . LEU A 1 117 ? 192.546 175.286 168.500 1.00 74.71  ? 117 LEU R CD2 1 
ATOM 792  N N   . ALA A 1 118 ? 188.716 171.965 170.898 1.00 79.26  ? 118 ALA R N   1 
ATOM 793  C CA  . ALA A 1 118 ? 188.240 171.221 172.056 1.00 79.26  ? 118 ALA R CA  1 
ATOM 794  C C   . ALA A 1 118 ? 188.665 169.761 172.002 1.00 79.26  ? 118 ALA R C   1 
ATOM 795  O O   . ALA A 1 118 ? 188.972 169.169 173.043 1.00 79.26  ? 118 ALA R O   1 
ATOM 796  C CB  . ALA A 1 118 ? 186.719 171.328 172.161 1.00 79.26  ? 118 ALA R CB  1 
ATOM 797  N N   . VAL A 1 119 ? 188.693 169.165 170.813 1.00 79.48  ? 119 VAL R N   1 
ATOM 798  C CA  . VAL A 1 119 ? 189.010 167.743 170.687 1.00 79.48  ? 119 VAL R CA  1 
ATOM 799  C C   . VAL A 1 119 ? 190.513 167.502 170.626 1.00 79.48  ? 119 VAL R C   1 
ATOM 800  O O   . VAL A 1 119 ? 191.047 166.669 171.362 1.00 79.48  ? 119 VAL R O   1 
ATOM 801  C CB  . VAL A 1 119 ? 188.296 167.153 169.455 1.00 79.48  ? 119 VAL R CB  1 
ATOM 802  C CG1 . VAL A 1 119 ? 188.694 165.703 169.264 1.00 79.48  ? 119 VAL R CG1 1 
ATOM 803  C CG2 . VAL A 1 119 ? 186.794 167.273 169.614 1.00 79.48  ? 119 VAL R CG2 1 
ATOM 804  N N   . ALA A 1 120 ? 191.216 168.217 169.745 1.00 78.67  ? 120 ALA R N   1 
ATOM 805  C CA  . ALA A 1 120 ? 192.636 167.955 169.528 1.00 78.67  ? 120 ALA R CA  1 
ATOM 806  C C   . ALA A 1 120 ? 193.459 168.233 170.776 1.00 78.67  ? 120 ALA R C   1 
ATOM 807  O O   . ALA A 1 120 ? 194.367 167.464 171.113 1.00 78.67  ? 120 ALA R O   1 
ATOM 808  C CB  . ALA A 1 120 ? 193.148 168.791 168.358 1.00 78.67  ? 120 ALA R CB  1 
ATOM 809  N N   . HIS A 1 121 ? 193.164 169.326 171.475 1.00 82.49  ? 121 HIS R N   1 
ATOM 810  C CA  . HIS A 1 121 ? 193.909 169.734 172.664 1.00 82.49  ? 121 HIS R CA  1 
ATOM 811  C C   . HIS A 1 121 ? 192.920 169.953 173.798 1.00 82.49  ? 121 HIS R C   1 
ATOM 812  O O   . HIS A 1 121 ? 192.560 171.095 174.114 1.00 82.49  ? 121 HIS R O   1 
ATOM 813  C CB  . HIS A 1 121 ? 194.733 170.991 172.395 1.00 82.49  ? 121 HIS R CB  1 
ATOM 814  C CG  . HIS A 1 121 ? 195.347 171.027 171.032 1.00 82.49  ? 121 HIS R CG  1 
ATOM 815  N ND1 . HIS A 1 121 ? 194.961 171.930 170.066 1.00 82.49  ? 121 HIS R ND1 1 
ATOM 816  C CD2 . HIS A 1 121 ? 196.318 170.269 170.471 1.00 82.49  ? 121 HIS R CD2 1 
ATOM 817  C CE1 . HIS A 1 121 ? 195.668 171.728 168.970 1.00 82.49  ? 121 HIS R CE1 1 
ATOM 818  N NE2 . HIS A 1 121 ? 196.498 170.725 169.189 1.00 82.49  ? 121 HIS R NE2 1 
ATOM 819  N N   . PRO A 1 122 ? 192.450 168.875 174.429 1.00 86.35  ? 122 PRO R N   1 
ATOM 820  C CA  . PRO A 1 122 ? 191.489 169.035 175.526 1.00 86.35  ? 122 PRO R CA  1 
ATOM 821  C C   . PRO A 1 122 ? 192.100 169.647 176.767 1.00 86.35  ? 122 PRO R C   1 
ATOM 822  O O   . PRO A 1 122 ? 191.361 170.173 177.608 1.00 86.35  ? 122 PRO R O   1 
ATOM 823  C CB  . PRO A 1 122 ? 191.019 167.602 175.784 1.00 86.35  ? 122 PRO R CB  1 
ATOM 824  C CG  . PRO A 1 122 ? 192.202 166.774 175.420 1.00 86.35  ? 122 PRO R CG  1 
ATOM 825  C CD  . PRO A 1 122 ? 192.899 167.479 174.290 1.00 86.35  ? 122 PRO R CD  1 
ATOM 826  N N   . LEU A 1 123 ? 193.420 169.598 176.906 1.00 83.06  ? 123 LEU R N   1 
ATOM 827  C CA  . LEU A 1 123 ? 194.105 170.068 178.098 1.00 83.06  ? 123 LEU R CA  1 
ATOM 828  C C   . LEU A 1 123 ? 194.563 171.515 177.994 1.00 83.06  ? 123 LEU R C   1 
ATOM 829  O O   . LEU A 1 123 ? 195.136 172.037 178.955 1.00 83.06  ? 123 LEU R O   1 
ATOM 830  C CB  . LEU A 1 123 ? 195.309 169.172 178.385 1.00 83.06  ? 123 LEU R CB  1 
ATOM 831  C CG  . LEU A 1 123 ? 195.040 167.776 178.936 1.00 83.06  ? 123 LEU R CG  1 
ATOM 832  C CD1 . LEU A 1 123 ? 196.320 167.175 179.483 1.00 83.06  ? 123 LEU R CD1 1 
ATOM 833  C CD2 . LEU A 1 123 ? 193.955 167.792 179.997 1.00 83.06  ? 123 LEU R CD2 1 
ATOM 834  N N   . ARG A 1 124 ? 194.333 172.176 176.857 1.00 87.63  ? 124 ARG R N   1 
ATOM 835  C CA  . ARG A 1 124 ? 194.863 173.520 176.665 1.00 87.63  ? 124 ARG R CA  1 
ATOM 836  C C   . ARG A 1 124 ? 193.880 174.452 175.963 1.00 87.63  ? 124 ARG R C   1 
ATOM 837  O O   . ARG A 1 124 ? 194.305 175.461 175.387 1.00 87.63  ? 124 ARG R O   1 
ATOM 838  C CB  . ARG A 1 124 ? 196.176 173.456 175.888 1.00 87.63  ? 124 ARG R CB  1 
ATOM 839  C CG  . ARG A 1 124 ? 197.384 173.218 176.771 1.00 87.63  ? 124 ARG R CG  1 
ATOM 840  C CD  . ARG A 1 124 ? 198.590 172.808 175.960 1.00 87.63  ? 124 ARG R CD  1 
ATOM 841  N NE  . ARG A 1 124 ? 198.572 171.382 175.660 1.00 87.63  ? 124 ARG R NE  1 
ATOM 842  C CZ  . ARG A 1 124 ? 199.420 170.497 176.173 1.00 87.63  ? 124 ARG R CZ  1 
ATOM 843  N NH1 . ARG A 1 124 ? 200.360 170.889 177.020 1.00 87.63  ? 124 ARG R NH1 1 
ATOM 844  N NH2 . ARG A 1 124 ? 199.325 169.219 175.842 1.00 87.63  ? 124 ARG R NH2 1 
ATOM 845  N N   . PHE A 1 125 ? 192.584 174.152 176.000 1.00 83.43  ? 125 PHE R N   1 
ATOM 846  C CA  . PHE A 1 125 ? 191.568 175.000 175.391 1.00 83.43  ? 125 PHE R CA  1 
ATOM 847  C C   . PHE A 1 125 ? 190.200 174.642 175.960 1.00 83.43  ? 125 PHE R C   1 
ATOM 848  O O   . PHE A 1 125 ? 189.825 173.465 175.957 1.00 83.43  ? 125 PHE R O   1 
ATOM 849  C CB  . PHE A 1 125 ? 191.583 174.841 173.867 1.00 83.43  ? 125 PHE R CB  1 
ATOM 850  C CG  . PHE A 1 125 ? 190.580 175.702 173.148 1.00 83.43  ? 125 PHE R CG  1 
ATOM 851  C CD1 . PHE A 1 125 ? 189.276 175.272 172.962 1.00 83.43  ? 125 PHE R CD1 1 
ATOM 852  C CD2 . PHE A 1 125 ? 190.947 176.938 172.647 1.00 83.43  ? 125 PHE R CD2 1 
ATOM 853  C CE1 . PHE A 1 125 ? 188.359 176.060 172.300 1.00 83.43  ? 125 PHE R CE1 1 
ATOM 854  C CE2 . PHE A 1 125 ? 190.032 177.730 171.982 1.00 83.43  ? 125 PHE R CE2 1 
ATOM 855  C CZ  . PHE A 1 125 ? 188.737 177.290 171.809 1.00 83.43  ? 125 PHE R CZ  1 
ATOM 856  N N   . PRO A 1 126 ? 189.413 175.616 176.447 1.00 90.67  ? 126 PRO R N   1 
ATOM 857  C CA  . PRO A 1 126 ? 189.636 177.065 176.569 1.00 90.67  ? 126 PRO R CA  1 
ATOM 858  C C   . PRO A 1 126 ? 190.682 177.456 177.614 1.00 90.67  ? 126 PRO R C   1 
ATOM 859  O O   . PRO A 1 126 ? 191.080 176.614 178.418 1.00 90.67  ? 126 PRO R O   1 
ATOM 860  C CB  . PRO A 1 126 ? 188.261 177.584 176.986 1.00 90.67  ? 126 PRO R CB  1 
ATOM 861  C CG  . PRO A 1 126 ? 187.311 176.576 176.453 1.00 90.67  ? 126 PRO R CG  1 
ATOM 862  C CD  . PRO A 1 126 ? 188.002 175.277 176.694 1.00 90.67  ? 126 PRO R CD  1 
ATOM 863  N N   . GLY A 1 127 ? 191.115 178.718 177.602 1.00 87.43  ? 127 GLY R N   1 
ATOM 864  C CA  . GLY A 1 127 ? 192.195 179.136 178.474 1.00 87.43  ? 127 GLY R CA  1 
ATOM 865  C C   . GLY A 1 127 ? 191.898 180.249 179.462 1.00 87.43  ? 127 GLY R C   1 
ATOM 866  O O   . GLY A 1 127 ? 192.510 180.292 180.533 1.00 87.43  ? 127 GLY R O   1 
ATOM 867  N N   . ALA A 1 128 ? 190.986 181.161 179.131 1.00 93.72  ? 128 ALA R N   1 
ATOM 868  C CA  . ALA A 1 128 ? 190.610 182.212 180.077 1.00 93.72  ? 128 ALA R CA  1 
ATOM 869  C C   . ALA A 1 128 ? 189.255 182.776 179.673 1.00 93.72  ? 128 ALA R C   1 
ATOM 870  O O   . ALA A 1 128 ? 189.177 183.532 178.699 1.00 93.72  ? 128 ALA R O   1 
ATOM 871  C CB  . ALA A 1 128 ? 191.668 183.307 180.119 1.00 93.72  ? 128 ALA R CB  1 
ATOM 872  N N   . ARG A 1 129 ? 188.201 182.431 180.441 1.00 90.81  ? 129 ARG R N   1 
ATOM 873  C CA  . ARG A 1 129 ? 186.814 182.870 180.264 1.00 90.81  ? 129 ARG R CA  1 
ATOM 874  C C   . ARG A 1 129 ? 186.470 182.964 178.782 1.00 90.81  ? 129 ARG R C   1 
ATOM 875  O O   . ARG A 1 129 ? 186.368 184.068 178.235 1.00 90.81  ? 129 ARG R O   1 
ATOM 876  C CB  . ARG A 1 129 ? 186.518 184.193 180.982 1.00 30.00  ? 129 ARG R CB  1 
ATOM 877  C CG  . ARG A 1 129 ? 187.562 185.286 180.912 1.00 30.00  ? 129 ARG R CG  1 
ATOM 878  C CD  . ARG A 1 129 ? 187.103 186.486 181.728 1.00 30.00  ? 129 ARG R CD  1 
ATOM 879  N NE  . ARG A 1 129 ? 188.216 187.339 182.132 1.00 30.00  ? 129 ARG R NE  1 
ATOM 880  C CZ  . ARG A 1 129 ? 188.117 188.648 182.329 1.00 30.00  ? 129 ARG R CZ  1 
ATOM 881  N NH1 . ARG A 1 129 ? 186.952 189.257 182.166 1.00 30.00  ? 129 ARG R NH1 1 
ATOM 882  N NH2 . ARG A 1 129 ? 189.182 189.347 182.695 1.00 30.00  ? 129 ARG R NH2 1 
ATOM 883  N N   . PRO A 1 130 ? 186.296 181.828 178.104 1.00 93.00  ? 130 PRO R N   1 
ATOM 884  C CA  . PRO A 1 130 ? 186.212 181.850 176.636 1.00 93.00  ? 130 PRO R CA  1 
ATOM 885  C C   . PRO A 1 130 ? 185.051 182.657 176.093 1.00 93.00  ? 130 PRO R C   1 
ATOM 886  O O   . PRO A 1 130 ? 185.064 182.995 174.904 1.00 93.00  ? 130 PRO R O   1 
ATOM 887  C CB  . PRO A 1 130 ? 186.075 180.368 176.272 1.00 93.00  ? 130 PRO R CB  1 
ATOM 888  C CG  . PRO A 1 130 ? 185.442 179.742 177.464 1.00 93.00  ? 130 PRO R CG  1 
ATOM 889  C CD  . PRO A 1 130 ? 185.830 180.552 178.672 1.00 93.00  ? 130 PRO R CD  1 
ATOM 890  N N   . ILE A 1 131 ? 184.047 182.971 176.914 1.00 94.80  ? 131 ILE R N   1 
ATOM 891  C CA  . ILE A 1 131 ? 182.929 183.779 176.438 1.00 94.80  ? 131 ILE R CA  1 
ATOM 892  C C   . ILE A 1 131 ? 183.418 185.138 175.956 1.00 94.80  ? 131 ILE R C   1 
ATOM 893  O O   . ILE A 1 131 ? 182.977 185.637 174.915 1.00 94.80  ? 131 ILE R O   1 
ATOM 894  C CB  . ILE A 1 131 ? 181.862 183.921 177.537 1.00 94.80  ? 131 ILE R CB  1 
ATOM 895  C CG1 . ILE A 1 131 ? 181.262 182.560 177.867 1.00 94.80  ? 131 ILE R CG1 1 
ATOM 896  C CG2 . ILE A 1 131 ? 180.778 184.884 177.102 1.00 94.80  ? 131 ILE R CG2 1 
ATOM 897  C CD1 . ILE A 1 131 ? 180.419 181.995 176.762 1.00 94.80  ? 131 ILE R CD1 1 
ATOM 898  N N   . ARG A 1 132 ? 184.350 185.748 176.689 1.00 107.49 ? 132 ARG R N   1 
ATOM 899  C CA  . ARG A 1 132 ? 184.815 187.086 176.336 1.00 107.49 ? 132 ARG R CA  1 
ATOM 900  C C   . ARG A 1 132 ? 185.530 187.091 174.989 1.00 107.49 ? 132 ARG R C   1 
ATOM 901  O O   . ARG A 1 132 ? 185.194 187.882 174.099 1.00 107.49 ? 132 ARG R O   1 
ATOM 902  C CB  . ARG A 1 132 ? 185.732 187.622 177.434 1.00 107.49 ? 132 ARG R CB  1 
ATOM 903  C CG  . ARG A 1 132 ? 186.137 189.070 177.251 1.00 107.49 ? 132 ARG R CG  1 
ATOM 904  C CD  . ARG A 1 132 ? 187.584 189.191 176.817 1.00 107.49 ? 132 ARG R CD  1 
ATOM 905  N NE  . ARG A 1 132 ? 188.490 188.505 177.730 1.00 107.49 ? 132 ARG R NE  1 
ATOM 906  C CZ  . ARG A 1 132 ? 188.994 189.051 178.830 1.00 107.49 ? 132 ARG R CZ  1 
ATOM 907  N NH1 . ARG A 1 132 ? 188.680 190.294 179.159 1.00 107.49 ? 132 ARG R NH1 1 
ATOM 908  N NH2 . ARG A 1 132 ? 189.814 188.353 179.600 1.00 107.49 ? 132 ARG R NH2 1 
ATOM 909  N N   . SER A 1 133 ? 186.517 186.208 174.817 1.00 103.66 ? 133 SER R N   1 
ATOM 910  C CA  . SER A 1 133 ? 187.252 186.168 173.558 1.00 103.66 ? 133 SER R CA  1 
ATOM 911  C C   . SER A 1 133 ? 186.368 185.713 172.406 1.00 103.66 ? 133 SER R C   1 
ATOM 912  O O   . SER A 1 133 ? 186.502 186.215 171.283 1.00 103.66 ? 133 SER R O   1 
ATOM 913  C CB  . SER A 1 133 ? 188.470 185.255 173.686 1.00 103.66 ? 133 SER R CB  1 
ATOM 914  O OG  . SER A 1 133 ? 189.231 185.255 172.492 1.00 103.66 ? 133 SER R OG  1 
ATOM 915  N N   . ALA A 1 134 ? 185.457 184.775 172.665 1.00 100.36 ? 134 ALA R N   1 
ATOM 916  C CA  . ALA A 1 134 ? 184.552 184.317 171.620 1.00 100.36 ? 134 ALA R CA  1 
ATOM 917  C C   . ALA A 1 134 ? 183.625 185.434 171.163 1.00 100.36 ? 134 ALA R C   1 
ATOM 918  O O   . ALA A 1 134 ? 183.377 185.592 169.962 1.00 100.36 ? 134 ALA R O   1 
ATOM 919  C CB  . ALA A 1 134 ? 183.756 183.115 172.119 1.00 100.36 ? 134 ALA R CB  1 
ATOM 920  N N   . ALA A 1 135 ? 183.111 186.231 172.104 1.00 96.45  ? 135 ALA R N   1 
ATOM 921  C CA  . ALA A 1 135 ? 182.265 187.359 171.736 1.00 96.45  ? 135 ALA R CA  1 
ATOM 922  C C   . ALA A 1 135 ? 183.064 188.433 171.013 1.00 96.45  ? 135 ALA R C   1 
ATOM 923  O O   . ALA A 1 135 ? 182.548 189.084 170.098 1.00 96.45  ? 135 ALA R O   1 
ATOM 924  C CB  . ALA A 1 135 ? 181.584 187.933 172.978 1.00 96.45  ? 135 ALA R CB  1 
ATOM 925  N N   . ALA A 1 136 ? 184.322 188.634 171.407 1.00 98.02  ? 136 ALA R N   1 
ATOM 926  C CA  . ALA A 1 136 ? 185.183 189.557 170.674 1.00 98.02  ? 136 ALA R CA  1 
ATOM 927  C C   . ALA A 1 136 ? 185.343 189.122 169.221 1.00 98.02  ? 136 ALA R C   1 
ATOM 928  O O   . ALA A 1 136 ? 185.194 189.930 168.296 1.00 98.02  ? 136 ALA R O   1 
ATOM 929  C CB  . ALA A 1 136 ? 186.546 189.662 171.360 1.00 98.02  ? 136 ALA R CB  1 
ATOM 930  N N   . VAL A 1 137 ? 185.632 187.837 169.003 1.00 102.03 ? 137 VAL R N   1 
ATOM 931  C CA  . VAL A 1 137 ? 185.802 187.330 167.642 1.00 102.03 ? 137 VAL R CA  1 
ATOM 932  C C   . VAL A 1 137 ? 184.495 187.427 166.864 1.00 102.03 ? 137 VAL R C   1 
ATOM 933  O O   . VAL A 1 137 ? 184.486 187.761 165.674 1.00 102.03 ? 137 VAL R O   1 
ATOM 934  C CB  . VAL A 1 137 ? 186.344 185.889 167.669 1.00 102.03 ? 137 VAL R CB  1 
ATOM 935  C CG1 . VAL A 1 137 ? 186.420 185.321 166.264 1.00 102.03 ? 137 VAL R CG1 1 
ATOM 936  C CG2 . VAL A 1 137 ? 187.718 185.857 168.317 1.00 102.03 ? 137 VAL R CG2 1 
ATOM 937  N N   . SER A 1 138 ? 183.372 187.140 167.523 1.00 96.17  ? 138 SER R N   1 
ATOM 938  C CA  . SER A 1 138 ? 182.075 187.223 166.860 1.00 96.17  ? 138 SER R CA  1 
ATOM 939  C C   . SER A 1 138 ? 181.764 188.649 166.419 1.00 96.17  ? 138 SER R C   1 
ATOM 940  O O   . SER A 1 138 ? 181.335 188.881 165.280 1.00 96.17  ? 138 SER R O   1 
ATOM 941  C CB  . SER A 1 138 ? 180.987 186.702 167.796 1.00 96.17  ? 138 SER R CB  1 
ATOM 942  O OG  . SER A 1 138 ? 179.711 186.848 167.209 1.00 96.17  ? 138 SER R OG  1 
ATOM 943  N N   . ALA A 1 139 ? 181.957 189.617 167.317 1.00 95.76  ? 139 ALA R N   1 
ATOM 944  C CA  . ALA A 1 139 ? 181.724 191.009 166.958 1.00 95.76  ? 139 ALA R CA  1 
ATOM 945  C C   . ALA A 1 139 ? 182.681 191.466 165.868 1.00 95.76  ? 139 ALA R C   1 
ATOM 946  O O   . ALA A 1 139 ? 182.300 192.263 165.003 1.00 95.76  ? 139 ALA R O   1 
ATOM 947  C CB  . ALA A 1 139 ? 181.852 191.901 168.192 1.00 95.76  ? 139 ALA R CB  1 
ATOM 948  N N   . LEU A 1 140 ? 183.917 190.964 165.879 1.00 92.90  ? 140 LEU R N   1 
ATOM 949  C CA  . LEU A 1 140 ? 184.851 191.323 164.818 1.00 92.90  ? 140 LEU R CA  1 
ATOM 950  C C   . LEU A 1 140 ? 184.389 190.766 163.478 1.00 92.90  ? 140 LEU R C   1 
ATOM 951  O O   . LEU A 1 140 ? 184.504 191.441 162.449 1.00 92.90  ? 140 LEU R O   1 
ATOM 952  C CB  . LEU A 1 140 ? 186.255 190.829 165.165 1.00 92.90  ? 140 LEU R CB  1 
ATOM 953  C CG  . LEU A 1 140 ? 187.431 191.273 164.293 1.00 92.90  ? 140 LEU R CG  1 
ATOM 954  C CD1 . LEU A 1 140 ? 188.700 191.289 165.123 1.00 92.90  ? 140 LEU R CD1 1 
ATOM 955  C CD2 . LEU A 1 140 ? 187.614 190.361 163.088 1.00 92.90  ? 140 LEU R CD2 1 
ATOM 956  N N   . ILE A 1 141 ? 183.863 189.540 163.470 1.00 98.99  ? 141 ILE R N   1 
ATOM 957  C CA  . ILE A 1 141 ? 183.332 188.964 162.236 1.00 98.99  ? 141 ILE R CA  1 
ATOM 958  C C   . ILE A 1 141 ? 182.162 189.791 161.727 1.00 98.99  ? 141 ILE R C   1 
ATOM 959  O O   . ILE A 1 141 ? 182.074 190.104 160.534 1.00 98.99  ? 141 ILE R O   1 
ATOM 960  C CB  . ILE A 1 141 ? 182.926 187.497 162.454 1.00 98.99  ? 141 ILE R CB  1 
ATOM 961  C CG1 . ILE A 1 141 ? 184.161 186.636 162.686 1.00 98.99  ? 141 ILE R CG1 1 
ATOM 962  C CG2 . ILE A 1 141 ? 182.128 186.979 161.272 1.00 98.99  ? 141 ILE R CG2 1 
ATOM 963  C CD1 . ILE A 1 141 ? 183.827 185.260 163.133 1.00 98.99  ? 141 ILE R CD1 1 
ATOM 964  N N   . TRP A 1 142 ? 181.244 190.156 162.624 1.00 90.12  ? 142 TRP R N   1 
ATOM 965  C CA  . TRP A 1 142 ? 180.099 190.968 162.217 1.00 90.12  ? 142 TRP R CA  1 
ATOM 966  C C   . TRP A 1 142 ? 180.552 192.296 161.622 1.00 90.12  ? 142 TRP R C   1 
ATOM 967  O O   . TRP A 1 142 ? 180.101 192.692 160.540 1.00 90.12  ? 142 TRP R O   1 
ATOM 968  C CB  . TRP A 1 142 ? 179.169 191.203 163.408 1.00 90.12  ? 142 TRP R CB  1 
ATOM 969  C CG  . TRP A 1 142 ? 178.201 190.089 163.668 1.00 90.12  ? 142 TRP R CG  1 
ATOM 970  C CD1 . TRP A 1 142 ? 178.261 189.174 164.674 1.00 90.12  ? 142 TRP R CD1 1 
ATOM 971  C CD2 . TRP A 1 142 ? 177.014 189.792 162.925 1.00 90.12  ? 142 TRP R CD2 1 
ATOM 972  N NE1 . TRP A 1 142 ? 177.193 188.315 164.597 1.00 90.12  ? 142 TRP R NE1 1 
ATOM 973  C CE2 . TRP A 1 142 ? 176.411 188.675 163.532 1.00 90.12  ? 142 TRP R CE2 1 
ATOM 974  C CE3 . TRP A 1 142 ? 176.405 190.358 161.802 1.00 90.12  ? 142 TRP R CE3 1 
ATOM 975  C CZ2 . TRP A 1 142 ? 175.232 188.113 163.055 1.00 90.12  ? 142 TRP R CZ2 1 
ATOM 976  C CZ3 . TRP A 1 142 ? 175.234 189.799 161.330 1.00 90.12  ? 142 TRP R CZ3 1 
ATOM 977  C CH2 . TRP A 1 142 ? 174.660 188.688 161.956 1.00 90.12  ? 142 TRP R CH2 1 
ATOM 978  N N   . MET A 1 143 ? 181.471 192.984 162.305 1.00 94.71  ? 143 MET R N   1 
ATOM 979  C CA  . MET A 1 143 ? 181.935 194.284 161.831 1.00 94.71  ? 143 MET R CA  1 
ATOM 980  C C   . MET A 1 143 ? 182.654 194.164 160.493 1.00 94.71  ? 143 MET R C   1 
ATOM 981  O O   . MET A 1 143 ? 182.405 194.950 159.571 1.00 94.71  ? 143 MET R O   1 
ATOM 982  C CB  . MET A 1 143 ? 182.847 194.927 162.876 1.00 94.71  ? 143 MET R CB  1 
ATOM 983  N N   . LEU A 1 144 ? 183.550 193.183 160.365 1.00 99.18  ? 144 LEU R N   1 
ATOM 984  C CA  . LEU A 1 144 ? 184.314 193.038 159.132 1.00 99.18  ? 144 LEU R CA  1 
ATOM 985  C C   . LEU A 1 144 ? 183.416 192.641 157.967 1.00 99.18  ? 144 LEU R C   1 
ATOM 986  O O   . LEU A 1 144 ? 183.598 193.129 156.847 1.00 99.18  ? 144 LEU R O   1 
ATOM 987  C CB  . LEU A 1 144 ? 185.438 192.020 159.329 1.00 99.18  ? 144 LEU R CB  1 
ATOM 988  C CG  . LEU A 1 144 ? 186.522 191.940 158.252 1.00 99.18  ? 144 LEU R CG  1 
ATOM 989  C CD1 . LEU A 1 144 ? 187.864 191.621 158.886 1.00 99.18  ? 144 LEU R CD1 1 
ATOM 990  C CD2 . LEU A 1 144 ? 186.179 190.898 157.197 1.00 99.18  ? 144 LEU R CD2 1 
ATOM 991  N N   . GLU A 1 145 ? 182.434 191.768 158.206 1.00 99.76  ? 145 GLU R N   1 
ATOM 992  C CA  . GLU A 1 145 ? 181.521 191.385 157.135 1.00 99.76  ? 145 GLU R CA  1 
ATOM 993  C C   . GLU A 1 145 ? 180.650 192.557 156.705 1.00 99.76  ? 145 GLU R C   1 
ATOM 994  O O   . GLU A 1 145 ? 180.420 192.756 155.506 1.00 99.76  ? 145 GLU R O   1 
ATOM 995  C CB  . GLU A 1 145 ? 180.657 190.207 157.577 1.00 99.76  ? 145 GLU R CB  1 
ATOM 996  N N   . LEU A 1 146 ? 180.151 193.342 157.664 1.00 99.95  ? 146 LEU R N   1 
ATOM 997  C CA  . LEU A 1 146 ? 179.371 194.520 157.299 1.00 99.95  ? 146 LEU R CA  1 
ATOM 998  C C   . LEU A 1 146 ? 180.216 195.517 156.515 1.00 99.95  ? 146 LEU R C   1 
ATOM 999  O O   . LEU A 1 146 ? 179.753 196.087 155.521 1.00 99.95  ? 146 LEU R O   1 
ATOM 1000 C CB  . LEU A 1 146 ? 178.781 195.173 158.548 1.00 99.95  ? 146 LEU R CB  1 
ATOM 1001 C CG  . LEU A 1 146 ? 177.712 194.376 159.301 1.00 99.95  ? 146 LEU R CG  1 
ATOM 1002 C CD1 . LEU A 1 146 ? 177.540 194.909 160.716 1.00 99.95  ? 146 LEU R CD1 1 
ATOM 1003 C CD2 . LEU A 1 146 ? 176.388 194.392 158.557 1.00 99.95  ? 146 LEU R CD2 1 
ATOM 1004 N N   . ALA A 1 147 ? 181.468 195.720 156.927 1.00 102.94 ? 147 ALA R N   1 
ATOM 1005 C CA  . ALA A 1 147 ? 182.340 196.660 156.238 1.00 102.94 ? 147 ALA R CA  1 
ATOM 1006 C C   . ALA A 1 147 ? 182.860 196.129 154.910 1.00 102.94 ? 147 ALA R C   1 
ATOM 1007 O O   . ALA A 1 147 ? 183.350 196.919 154.096 1.00 102.94 ? 147 ALA R O   1 
ATOM 1008 C CB  . ALA A 1 147 ? 183.522 197.037 157.135 1.00 102.94 ? 147 ALA R CB  1 
ATOM 1009 N N   . ALA A 1 148 ? 182.777 194.823 154.675 1.00 101.77 ? 148 ALA R N   1 
ATOM 1010 C CA  . ALA A 1 148 ? 183.116 194.267 153.374 1.00 101.77 ? 148 ALA R CA  1 
ATOM 1011 C C   . ALA A 1 148 ? 181.925 194.224 152.430 1.00 101.77 ? 148 ALA R C   1 
ATOM 1012 O O   . ALA A 1 148 ? 182.115 194.255 151.209 1.00 101.77 ? 148 ALA R O   1 
ATOM 1013 C CB  . ALA A 1 148 ? 183.692 192.857 153.531 1.00 101.77 ? 148 ALA R CB  1 
ATOM 1014 N N   . ASN A 1 149 ? 180.708 194.150 152.965 1.00 102.57 ? 149 ASN R N   1 
ATOM 1015 C CA  . ASN A 1 149 ? 179.503 194.220 152.155 1.00 102.57 ? 149 ASN R CA  1 
ATOM 1016 C C   . ASN A 1 149 ? 179.008 195.645 151.944 1.00 102.57 ? 149 ASN R C   1 
ATOM 1017 O O   . ASN A 1 149 ? 178.102 195.852 151.132 1.00 102.57 ? 149 ASN R O   1 
ATOM 1018 C CB  . ASN A 1 149 ? 178.388 193.390 152.798 1.00 102.57 ? 149 ASN R CB  1 
ATOM 1019 C CG  . ASN A 1 149 ? 178.433 191.936 152.384 1.00 102.57 ? 149 ASN R CG  1 
ATOM 1020 O OD1 . ASN A 1 149 ? 178.684 191.055 153.204 1.00 102.57 ? 149 ASN R OD1 1 
ATOM 1021 N ND2 . ASN A 1 149 ? 178.188 191.677 151.107 1.00 102.57 ? 149 ASN R ND2 1 
ATOM 1022 N N   . ALA A 1 150 ? 179.559 196.620 152.669 1.00 98.69  ? 150 ALA R N   1 
ATOM 1023 C CA  . ALA A 1 150 ? 179.144 198.009 152.487 1.00 98.69  ? 150 ALA R CA  1 
ATOM 1024 C C   . ALA A 1 150 ? 179.248 198.517 151.051 1.00 98.69  ? 150 ALA R C   1 
ATOM 1025 O O   . ALA A 1 150 ? 178.333 199.243 150.624 1.00 98.69  ? 150 ALA R O   1 
ATOM 1026 C CB  . ALA A 1 150 ? 179.940 198.914 153.436 1.00 98.69  ? 150 ALA R CB  1 
ATOM 1027 N N   . PRO A 1 151 ? 180.286 198.215 150.269 1.00 98.21  ? 151 PRO R N   1 
ATOM 1028 C CA  . PRO A 1 151 ? 180.326 198.716 148.887 1.00 98.21  ? 151 PRO R CA  1 
ATOM 1029 C C   . PRO A 1 151 ? 179.278 198.044 148.020 1.00 98.21  ? 151 PRO R C   1 
ATOM 1030 O O   . PRO A 1 151 ? 179.090 198.426 146.855 1.00 98.21  ? 151 PRO R O   1 
ATOM 1031 C CB  . PRO A 1 151 ? 181.747 198.366 148.419 1.00 30.00  ? 151 PRO R CB  1 
ATOM 1032 C CG  . PRO A 1 151 ? 182.186 197.270 149.296 1.00 30.00  ? 151 PRO R CG  1 
ATOM 1033 C CD  . PRO A 1 151 ? 181.535 197.512 150.621 1.00 30.00  ? 151 PRO R CD  1 
ATOM 1034 N N   . PRO A 1 152 ? 178.572 197.037 148.543 1.00 96.39  ? 152 PRO R N   1 
ATOM 1035 C CA  . PRO A 1 152 ? 177.527 196.386 147.740 1.00 96.39  ? 152 PRO R CA  1 
ATOM 1036 C C   . PRO A 1 152 ? 176.128 196.935 147.993 1.00 96.39  ? 152 PRO R C   1 
ATOM 1037 O O   . PRO A 1 152 ? 175.181 196.549 147.299 1.00 96.39  ? 152 PRO R O   1 
ATOM 1038 C CB  . PRO A 1 152 ? 177.634 194.914 148.158 1.00 30.00  ? 152 PRO R CB  1 
ATOM 1039 N N   . LEU A 1 153 ? 175.969 197.814 148.987 1.00 99.59  ? 153 LEU R N   1 
ATOM 1040 C CA  . LEU A 1 153 ? 174.661 198.432 149.228 1.00 99.59  ? 153 LEU R CA  1 
ATOM 1041 C C   . LEU A 1 153 ? 174.876 199.815 149.850 1.00 99.59  ? 153 LEU R C   1 
ATOM 1042 O O   . LEU A 1 153 ? 174.975 199.952 151.071 1.00 99.59  ? 153 LEU R O   1 
ATOM 1043 C CB  . LEU A 1 153 ? 173.793 197.551 150.112 1.00 99.59  ? 153 LEU R CB  1 
ATOM 1044 N N   . LEU A 1 154 ? 174.925 200.835 148.993 1.00 99.68  ? 154 LEU R N   1 
ATOM 1045 C CA  . LEU A 1 154 ? 174.981 202.214 149.458 1.00 99.68  ? 154 LEU R CA  1 
ATOM 1046 C C   . LEU A 1 154 ? 174.165 203.155 148.580 1.00 99.68  ? 154 LEU R C   1 
ATOM 1047 O O   . LEU A 1 154 ? 174.238 204.376 148.774 1.00 99.68  ? 154 LEU R O   1 
ATOM 1048 C CB  . LEU A 1 154 ? 176.433 202.703 149.528 1.00 99.68  ? 154 LEU R CB  1 
ATOM 1049 N N   . GLY A 1 155 ? 173.394 202.637 147.629 1.00 104.20 ? 155 GLY R N   1 
ATOM 1050 C CA  . GLY A 1 155 ? 172.710 203.486 146.676 1.00 104.20 ? 155 GLY R CA  1 
ATOM 1051 C C   . GLY A 1 155 ? 173.638 203.932 145.565 1.00 104.20 ? 155 GLY R C   1 
ATOM 1052 O O   . GLY A 1 155 ? 173.790 205.132 145.316 1.00 104.20 ? 155 GLY R O   1 
ATOM 1053 N N   . GLU A 1 156 ? 174.271 202.971 144.893 1.00 112.15 ? 156 GLU R N   1 
ATOM 1054 C CA  . GLU A 1 156 ? 175.269 203.253 143.869 1.00 112.15 ? 156 GLU R CA  1 
ATOM 1055 C C   . GLU A 1 156 ? 174.785 202.952 142.459 1.00 112.15 ? 156 GLU R C   1 
ATOM 1056 O O   . GLU A 1 156 ? 174.910 203.802 141.573 1.00 112.15 ? 156 GLU R O   1 
ATOM 1057 C CB  . GLU A 1 156 ? 176.552 202.459 144.156 1.00 112.15 ? 156 GLU R CB  1 
ATOM 1058 N N   . ALA A 1 157 ? 174.229 201.764 142.221 1.00 30.00  ? 157 ALA R N   1 
ATOM 1059 C CA  . ALA A 1 157 ? 173.855 201.354 140.875 1.00 30.00  ? 157 ALA R CA  1 
ATOM 1060 C C   . ALA A 1 157 ? 172.536 200.594 140.889 1.00 30.00  ? 157 ALA R C   1 
ATOM 1061 O O   . ALA A 1 157 ? 172.219 199.877 141.842 1.00 30.00  ? 157 ALA R O   1 
ATOM 1062 C CB  . ALA A 1 157 ? 174.943 200.484 140.235 1.00 30.00  ? 157 ALA R CB  1 
ATOM 1063 N N   . ILE A 1 158 ? 171.775 200.764 139.806 1.00 124.84 ? 158 ILE R N   1 
ATOM 1064 C CA  . ILE A 1 158 ? 170.560 200.002 139.528 1.00 124.84 ? 158 ILE R CA  1 
ATOM 1065 C C   . ILE A 1 158 ? 170.226 200.224 138.057 1.00 124.84 ? 158 ILE R C   1 
ATOM 1066 O O   . ILE A 1 158 ? 170.504 201.296 137.506 1.00 124.84 ? 158 ILE R O   1 
ATOM 1067 C CB  . ILE A 1 158 ? 169.399 200.407 140.460 1.00 124.84 ? 158 ILE R CB  1 
ATOM 1068 C CG1 . ILE A 1 158 ? 168.368 199.280 140.551 1.00 124.84 ? 158 ILE R CG1 1 
ATOM 1069 C CG2 . ILE A 1 158 ? 168.746 201.705 140.000 1.00 124.84 ? 158 ILE R CG2 1 
ATOM 1070 C CD1 . ILE A 1 158 ? 167.451 199.394 141.741 1.00 124.84 ? 158 ILE R CD1 1 
ATOM 1071 N N   . HIS A 1 159 ? 169.660 199.216 137.396 1.00 130.75 ? 159 HIS R N   1 
ATOM 1072 C CA  . HIS A 1 159 ? 169.530 199.295 135.946 1.00 130.75 ? 159 HIS R CA  1 
ATOM 1073 C C   . HIS A 1 159 ? 168.388 198.413 135.462 1.00 130.75 ? 159 HIS R C   1 
ATOM 1074 O O   . HIS A 1 159 ? 167.900 197.537 136.182 1.00 130.75 ? 159 HIS R O   1 
ATOM 1075 C CB  . HIS A 1 159 ? 170.839 198.896 135.254 1.00 130.75 ? 159 HIS R CB  1 
ATOM 1076 C CG  . HIS A 1 159 ? 170.985 199.447 133.871 1.00 130.75 ? 159 HIS R CG  1 
ATOM 1077 N ND1 . HIS A 1 159 ? 171.167 200.789 133.620 1.00 130.75 ? 159 HIS R ND1 1 
ATOM 1078 C CD2 . HIS A 1 159 ? 170.973 198.836 132.662 1.00 130.75 ? 159 HIS R CD2 1 
ATOM 1079 C CE1 . HIS A 1 159 ? 171.263 200.982 132.316 1.00 130.75 ? 159 HIS R CE1 1 
ATOM 1080 N NE2 . HIS A 1 159 ? 171.148 199.813 131.713 1.00 130.75 ? 159 HIS R NE2 1 
ATOM 1081 N N   . ARG A 1 160 ? 167.975 198.665 134.219 1.00 136.11 ? 160 ARG R N   1 
ATOM 1082 C CA  . ARG A 1 160 ? 166.962 197.881 133.526 1.00 136.11 ? 160 ARG R CA  1 
ATOM 1083 C C   . ARG A 1 160 ? 167.287 197.899 132.039 1.00 136.11 ? 160 ARG R C   1 
ATOM 1084 O O   . ARG A 1 160 ? 167.646 198.948 131.497 1.00 136.11 ? 160 ARG R O   1 
ATOM 1085 C CB  . ARG A 1 160 ? 165.553 198.431 133.773 1.00 136.11 ? 160 ARG R CB  1 
ATOM 1086 N N   . ASP A 1 161 ? 167.162 196.745 131.379 1.00 133.01 ? 161 ASP R N   1 
ATOM 1087 C CA  . ASP A 1 161 ? 167.653 196.622 130.009 1.00 133.01 ? 161 ASP R CA  1 
ATOM 1088 C C   . ASP A 1 161 ? 166.551 196.404 128.979 1.00 133.01 ? 161 ASP R C   1 
ATOM 1089 O O   . ASP A 1 161 ? 166.410 197.227 128.069 1.00 133.01 ? 161 ASP R O   1 
ATOM 1090 C CB  . ASP A 1 161 ? 168.692 195.493 129.934 1.00 133.01 ? 161 ASP R CB  1 
ATOM 1091 C CG  . ASP A 1 161 ? 168.183 194.189 130.513 1.00 133.01 ? 161 ASP R CG  1 
ATOM 1092 O OD1 . ASP A 1 161 ? 167.282 194.233 131.375 1.00 133.01 ? 161 ASP R OD1 1 
ATOM 1093 O OD2 . ASP A 1 161 ? 168.688 193.121 130.108 1.00 133.01 ? 161 ASP R OD2 1 
ATOM 1094 N N   . ARG A 1 162 ? 165.759 195.334 129.077 1.00 139.28 ? 162 ARG R N   1 
ATOM 1095 C CA  . ARG A 1 162 ? 164.831 195.048 127.988 1.00 139.28 ? 162 ARG R CA  1 
ATOM 1096 C C   . ARG A 1 162 ? 163.392 195.433 128.306 1.00 139.28 ? 162 ARG R C   1 
ATOM 1097 O O   . ARG A 1 162 ? 162.820 196.311 127.651 1.00 139.28 ? 162 ARG R O   1 
ATOM 1098 C CB  . ARG A 1 162 ? 164.888 193.561 127.623 1.00 139.28 ? 162 ARG R CB  1 
ATOM 1099 N N   . TYR A 1 163 ? 162.803 194.785 129.309 1.00 133.71 ? 163 TYR R N   1 
ATOM 1100 C CA  . TYR A 1 163 ? 161.418 195.043 129.684 1.00 133.71 ? 163 TYR R CA  1 
ATOM 1101 C C   . TYR A 1 163 ? 161.105 194.430 131.041 1.00 133.71 ? 163 TYR R C   1 
ATOM 1102 O O   . TYR A 1 163 ? 161.129 193.204 131.188 1.00 133.71 ? 163 TYR R O   1 
ATOM 1103 C CB  . TYR A 1 163 ? 160.459 194.496 128.624 1.00 133.71 ? 163 TYR R CB  1 
ATOM 1104 N N   . ASN A 1 164 ? 160.792 195.270 132.026 1.00 134.59 ? 164 ASN R N   1 
ATOM 1105 C CA  . ASN A 1 164 ? 160.487 194.816 133.381 1.00 134.59 ? 164 ASN R CA  1 
ATOM 1106 C C   . ASN A 1 164 ? 161.594 193.907 133.913 1.00 134.59 ? 164 ASN R C   1 
ATOM 1107 O O   . ASN A 1 164 ? 161.351 192.800 134.398 1.00 134.59 ? 164 ASN R O   1 
ATOM 1108 C CB  . ASN A 1 164 ? 159.126 194.120 133.431 1.00 134.59 ? 164 ASN R CB  1 
ATOM 1109 N N   . HIS A 1 165 ? 162.833 194.381 133.795 1.00 134.39 ? 165 HIS R N   1 
ATOM 1110 C CA  . HIS A 1 165 ? 164.009 193.680 134.312 1.00 134.39 ? 165 HIS R CA  1 
ATOM 1111 C C   . HIS A 1 165 ? 164.815 194.695 135.115 1.00 134.39 ? 165 HIS R C   1 
ATOM 1112 O O   . HIS A 1 165 ? 165.767 195.285 134.602 1.00 134.39 ? 165 HIS R O   1 
ATOM 1113 C CB  . HIS A 1 165 ? 164.825 193.069 133.182 1.00 134.39 ? 165 HIS R CB  1 
ATOM 1114 C CG  . HIS A 1 165 ? 164.367 191.705 132.775 1.00 134.39 ? 165 HIS R CG  1 
ATOM 1115 N ND1 . HIS A 1 165 ? 164.719 190.566 133.466 1.00 134.39 ? 165 HIS R ND1 1 
ATOM 1116 C CD2 . HIS A 1 165 ? 163.589 191.294 131.747 1.00 134.39 ? 165 HIS R CD2 1 
ATOM 1117 C CE1 . HIS A 1 165 ? 164.175 189.512 132.883 1.00 134.39 ? 165 HIS R CE1 1 
ATOM 1118 N NE2 . HIS A 1 165 ? 163.485 189.927 131.836 1.00 134.39 ? 165 HIS R NE2 1 
ATOM 1119 N N   . THR A 1 166 ? 164.436 194.947 136.368 1.00 131.06 ? 166 THR R N   1 
ATOM 1120 C CA  . THR A 1 166 ? 165.204 195.853 137.234 1.00 131.06 ? 166 THR R CA  1 
ATOM 1121 C C   . THR A 1 166 ? 165.402 195.117 138.528 1.00 131.06 ? 166 THR R C   1 
ATOM 1122 O O   . THR A 1 166 ? 164.798 195.364 139.528 1.00 131.06 ? 166 THR R O   1 
ATOM 1123 C CB  . THR A 1 166 ? 164.539 197.201 137.449 1.00 131.06 ? 166 THR R CB  1 
ATOM 1124 O OG1 . THR A 1 166 ? 164.277 197.821 136.206 1.00 131.06 ? 166 THR R OG1 1 
ATOM 1125 C CG2 . THR A 1 166 ? 165.465 198.094 138.185 1.00 131.06 ? 166 THR R CG2 1 
ATOM 1126 N N   . PHE A 1 167 ? 166.215 194.066 138.513 1.00 128.62 ? 167 PHE R N   1 
ATOM 1127 C CA  . PHE A 1 167 ? 166.439 193.323 139.761 1.00 128.62 ? 167 PHE R CA  1 
ATOM 1128 C C   . PHE A 1 167 ? 167.323 194.225 140.607 1.00 128.62 ? 167 PHE R C   1 
ATOM 1129 O O   . PHE A 1 167 ? 168.239 194.853 140.074 1.00 128.62 ? 167 PHE R O   1 
ATOM 1130 C CB  . PHE A 1 167 ? 167.076 191.962 139.505 1.00 30.00  ? 167 PHE R CB  1 
ATOM 1131 N N   . CYS A 1 168 ? 167.080 194.311 141.911 1.00 122.84 ? 168 CYS R N   1 
ATOM 1132 C CA  . CYS A 1 168 ? 167.886 195.241 142.695 1.00 122.84 ? 168 CYS R CA  1 
ATOM 1133 C C   . CYS A 1 168 ? 169.380 194.930 142.738 1.00 122.84 ? 168 CYS R C   1 
ATOM 1134 O O   . CYS A 1 168 ? 169.797 193.792 142.971 1.00 122.84 ? 168 CYS R O   1 
ATOM 1135 C CB  . CYS A 1 168 ? 167.342 195.461 144.101 1.00 30.00  ? 168 CYS R CB  1 
ATOM 1136 S SG  . CYS A 1 168 ? 168.276 196.746 144.967 1.00 30.00  ? 168 CYS R SG  1 
ATOM 1137 N N   . TYR A 1 169 ? 170.149 196.001 142.538 1.00 112.61 ? 169 TYR R N   1 
ATOM 1138 C CA  . TYR A 1 169 ? 171.623 196.030 142.525 1.00 112.61 ? 169 TYR R CA  1 
ATOM 1139 C C   . TYR A 1 169 ? 172.339 194.926 141.721 1.00 112.61 ? 169 TYR R C   1 
ATOM 1140 O O   . TYR A 1 169 ? 173.521 194.687 141.959 1.00 112.61 ? 169 TYR R O   1 
ATOM 1141 C CB  . TYR A 1 169 ? 172.242 195.663 143.867 1.00 30.00  ? 169 TYR R CB  1 
ATOM 1142 C CG  . TYR A 1 169 ? 173.600 195.025 143.711 1.00 30.00  ? 169 TYR R CG  1 
ATOM 1143 C CD1 . TYR A 1 169 ? 174.757 195.789 143.751 1.00 30.00  ? 169 TYR R CD1 1 
ATOM 1144 C CD2 . TYR A 1 169 ? 173.722 193.662 143.475 1.00 30.00  ? 169 TYR R CD2 1 
ATOM 1145 C CE1 . TYR A 1 169 ? 176.000 195.209 143.586 1.00 30.00  ? 169 TYR R CE1 1 
ATOM 1146 C CE2 . TYR A 1 169 ? 174.960 193.076 143.308 1.00 30.00  ? 169 TYR R CE2 1 
ATOM 1147 C CZ  . TYR A 1 169 ? 176.094 193.855 143.367 1.00 30.00  ? 169 TYR R CZ  1 
ATOM 1148 O OH  . TYR A 1 169 ? 177.332 193.277 143.206 1.00 30.00  ? 169 TYR R OH  1 
ATOM 1149 N N   . GLU A 1 170 ? 171.679 194.274 140.792 1.00 118.07 ? 170 GLU R N   1 
ATOM 1150 C CA  . GLU A 1 170 ? 172.394 193.510 139.796 1.00 118.07 ? 170 GLU R CA  1 
ATOM 1151 C C   . GLU A 1 170 ? 173.052 194.125 138.552 1.00 118.07 ? 170 GLU R C   1 
ATOM 1152 O O   . GLU A 1 170 ? 172.683 195.207 138.091 1.00 118.07 ? 170 GLU R O   1 
ATOM 1153 C CB  . GLU A 1 170 ? 171.525 192.316 139.426 1.00 118.07 ? 170 GLU R CB  1 
ATOM 1154 C CG  . GLU A 1 170 ? 170.757 191.804 140.628 1.00 118.07 ? 170 GLU R CG  1 
ATOM 1155 C CD  . GLU A 1 170 ? 170.581 190.306 140.610 1.00 118.07 ? 170 GLU R CD  1 
ATOM 1156 O OE1 . GLU A 1 170 ? 170.562 189.726 139.511 1.00 118.07 ? 170 GLU R OE1 1 
ATOM 1157 O OE2 . GLU A 1 170 ? 170.462 189.707 141.697 1.00 118.07 ? 170 GLU R OE2 1 
ATOM 1158 N N   . SER A 1 171 ? 174.070 193.425 138.034 1.00 114.98 ? 171 SER R N   1 
ATOM 1159 C CA  . SER A 1 171 ? 174.826 193.939 136.900 1.00 114.98 ? 171 SER R CA  1 
ATOM 1160 C C   . SER A 1 171 ? 174.961 193.100 135.667 1.00 114.98 ? 171 SER R C   1 
ATOM 1161 O O   . SER A 1 171 ? 176.011 192.613 135.417 1.00 114.98 ? 171 SER R O   1 
ATOM 1162 C CB  . SER A 1 171 ? 176.216 194.372 137.361 1.00 114.98 ? 171 SER R CB  1 
ATOM 1163 N N   . TYR A 1 172 ? 173.916 193.019 134.857 1.00 117.08 ? 172 TYR R N   1 
ATOM 1164 C CA  . TYR A 1 172 ? 173.957 192.259 133.613 1.00 117.08 ? 172 TYR R CA  1 
ATOM 1165 C C   . TYR A 1 172 ? 174.147 193.220 132.448 1.00 117.08 ? 172 TYR R C   1 
ATOM 1166 O O   . TYR A 1 172 ? 173.214 193.968 132.115 1.00 117.08 ? 172 TYR R O   1 
ATOM 1167 C CB  . TYR A 1 172 ? 172.672 191.450 133.423 1.00 117.08 ? 172 TYR R CB  1 
ATOM 1168 C CG  . TYR A 1 172 ? 172.338 190.517 134.560 1.00 117.08 ? 172 TYR R CG  1 
ATOM 1169 C CD1 . TYR A 1 172 ? 171.104 190.580 135.190 1.00 117.08 ? 172 TYR R CD1 1 
ATOM 1170 C CD2 . TYR A 1 172 ? 173.252 189.573 135.004 1.00 117.08 ? 172 TYR R CD2 1 
ATOM 1171 C CE1 . TYR A 1 172 ? 170.789 189.730 136.228 1.00 117.08 ? 172 TYR R CE1 1 
ATOM 1172 C CE2 . TYR A 1 172 ? 172.946 188.718 136.043 1.00 117.08 ? 172 TYR R CE2 1 
ATOM 1173 C CZ  . TYR A 1 172 ? 171.713 188.801 136.652 1.00 117.08 ? 172 TYR R CZ  1 
ATOM 1174 O OH  . TYR A 1 172 ? 171.405 187.951 137.689 1.00 117.08 ? 172 TYR R OH  1 
ATOM 1175 N N   . PRO A 1 173 ? 175.320 193.255 131.802 1.00 117.39 ? 173 PRO R N   1 
ATOM 1176 C CA  . PRO A 1 173 ? 176.507 192.488 132.184 1.00 117.39 ? 173 PRO R CA  1 
ATOM 1177 C C   . PRO A 1 173 ? 177.274 193.164 133.315 1.00 117.39 ? 173 PRO R C   1 
ATOM 1178 O O   . PRO A 1 173 ? 176.806 194.164 133.858 1.00 117.39 ? 173 PRO R O   1 
ATOM 1179 C CB  . PRO A 1 173 ? 177.331 192.464 130.898 1.00 117.39 ? 173 PRO R CB  1 
ATOM 1180 C CG  . PRO A 1 173 ? 176.982 193.744 130.223 1.00 117.39 ? 173 PRO R CG  1 
ATOM 1181 C CD  . PRO A 1 173 ? 175.546 194.045 130.578 1.00 117.39 ? 173 PRO R CD  1 
ATOM 1182 N N   . LEU A 1 174 ? 178.442 192.626 133.655 1.00 116.21 ? 174 LEU R N   1 
ATOM 1183 C CA  . LEU A 1 174 ? 179.204 193.146 134.781 1.00 116.21 ? 174 LEU R CA  1 
ATOM 1184 C C   . LEU A 1 174 ? 179.745 194.537 134.469 1.00 116.21 ? 174 LEU R C   1 
ATOM 1185 O O   . LEU A 1 174 ? 180.055 194.858 133.319 1.00 116.21 ? 174 LEU R O   1 
ATOM 1186 C CB  . LEU A 1 174 ? 180.340 192.188 135.134 1.00 116.21 ? 174 LEU R CB  1 
ATOM 1187 C CG  . LEU A 1 174 ? 179.852 190.831 135.652 1.00 116.21 ? 174 LEU R CG  1 
ATOM 1188 C CD1 . LEU A 1 174 ? 181.016 189.880 135.866 1.00 116.21 ? 174 LEU R CD1 1 
ATOM 1189 C CD2 . LEU A 1 174 ? 179.040 190.983 136.925 1.00 116.21 ? 174 LEU R CD2 1 
ATOM 1190 N N   . SER A 1 175 ? 179.849 195.369 135.512 1.00 113.30 ? 175 SER R N   1 
ATOM 1191 C CA  . SER A 1 175 ? 180.178 196.780 135.324 1.00 113.30 ? 175 SER R CA  1 
ATOM 1192 C C   . SER A 1 175 ? 181.506 196.975 134.601 1.00 113.30 ? 175 SER R C   1 
ATOM 1193 O O   . SER A 1 175 ? 181.690 197.983 133.910 1.00 113.30 ? 175 SER R O   1 
ATOM 1194 C CB  . SER A 1 175 ? 180.209 197.492 136.676 1.00 113.30 ? 175 SER R CB  1 
ATOM 1195 O OG  . SER A 1 175 ? 179.034 197.221 137.421 1.00 113.30 ? 175 SER R OG  1 
ATOM 1196 N N   . GLY A 1 176 ? 182.430 196.044 134.743 1.00 110.56 ? 176 GLY R N   1 
ATOM 1197 C CA  . GLY A 1 176 ? 183.712 196.136 134.074 1.00 110.56 ? 176 GLY R CA  1 
ATOM 1198 C C   . GLY A 1 176 ? 184.804 195.499 134.904 1.00 110.56 ? 176 GLY R C   1 
ATOM 1199 O O   . GLY A 1 176 ? 184.686 195.317 136.114 1.00 110.56 ? 176 GLY R O   1 
ATOM 1200 N N   . ARG A 1 177 ? 185.904 195.162 134.227 1.00 114.07 ? 177 ARG R N   1 
ATOM 1201 C CA  . ARG A 1 177 ? 187.039 194.533 134.893 1.00 114.07 ? 177 ARG R CA  1 
ATOM 1202 C C   . ARG A 1 177 ? 187.619 195.402 136.002 1.00 114.07 ? 177 ARG R C   1 
ATOM 1203 O O   . ARG A 1 177 ? 188.263 194.872 136.914 1.00 114.07 ? 177 ARG R O   1 
ATOM 1204 C CB  . ARG A 1 177 ? 188.126 194.197 133.872 1.00 114.07 ? 177 ARG R CB  1 
ATOM 1205 N N   . GLY A 1 178 ? 187.412 196.717 135.945 1.00 108.57 ? 178 GLY R N   1 
ATOM 1206 C CA  . GLY A 1 178 ? 187.831 197.576 137.036 1.00 108.57 ? 178 GLY R CA  1 
ATOM 1207 C C   . GLY A 1 178 ? 186.938 197.516 138.258 1.00 108.57 ? 178 GLY R C   1 
ATOM 1208 O O   . GLY A 1 178 ? 187.309 198.063 139.303 1.00 108.57 ? 178 GLY R O   1 
ATOM 1209 N N   . ALA A 1 179 ? 185.774 196.877 138.152 1.00 102.06 ? 179 ALA R N   1 
ATOM 1210 C CA  . ALA A 1 179 ? 184.886 196.719 139.296 1.00 102.06 ? 179 ALA R CA  1 
ATOM 1211 C C   . ALA A 1 179 ? 184.294 195.327 139.430 1.00 102.06 ? 179 ALA R C   1 
ATOM 1212 O O   . ALA A 1 179 ? 183.671 195.048 140.459 1.00 102.06 ? 179 ALA R O   1 
ATOM 1213 C CB  . ALA A 1 179 ? 183.741 197.741 139.232 1.00 102.06 ? 179 ALA R CB  1 
ATOM 1214 N N   . ALA A 1 180 ? 184.459 194.445 138.444 1.00 99.14  ? 180 ALA R N   1 
ATOM 1215 C CA  . ALA A 1 180 ? 183.890 193.106 138.519 1.00 99.14  ? 180 ALA R CA  1 
ATOM 1216 C C   . ALA A 1 180 ? 184.592 192.221 139.537 1.00 99.14  ? 180 ALA R C   1 
ATOM 1217 O O   . ALA A 1 180 ? 184.111 191.114 139.800 1.00 99.14  ? 180 ALA R O   1 
ATOM 1218 C CB  . ALA A 1 180 ? 183.929 192.435 137.145 1.00 99.14  ? 180 ALA R CB  1 
ATOM 1219 N N   . LEU A 1 181 ? 185.706 192.670 140.108 1.00 95.90  ? 181 LEU R N   1 
ATOM 1220 C CA  . LEU A 1 181 ? 186.474 191.845 141.031 1.00 95.90  ? 181 LEU R CA  1 
ATOM 1221 C C   . LEU A 1 181 ? 185.826 191.717 142.402 1.00 95.90  ? 181 LEU R C   1 
ATOM 1222 O O   . LEU A 1 181 ? 186.356 190.993 143.250 1.00 95.90  ? 181 LEU R O   1 
ATOM 1223 C CB  . LEU A 1 181 ? 187.891 192.403 141.178 1.00 95.90  ? 181 LEU R CB  1 
ATOM 1224 C CG  . LEU A 1 181 ? 188.690 192.449 139.876 1.00 95.90  ? 181 LEU R CG  1 
ATOM 1225 C CD1 . LEU A 1 181 ? 190.089 192.988 140.108 1.00 95.90  ? 181 LEU R CD1 1 
ATOM 1226 C CD2 . LEU A 1 181 ? 188.743 191.076 139.245 1.00 95.90  ? 181 LEU R CD2 1 
ATOM 1227 N N   . ALA A 1 182 ? 184.697 192.388 142.638 1.00 95.13  ? 182 ALA R N   1 
ATOM 1228 C CA  . ALA A 1 182 ? 183.977 192.194 143.891 1.00 95.13  ? 182 ALA R CA  1 
ATOM 1229 C C   . ALA A 1 182 ? 183.509 190.753 144.031 1.00 95.13  ? 182 ALA R C   1 
ATOM 1230 O O   . ALA A 1 182 ? 183.587 190.168 145.117 1.00 95.13  ? 182 ALA R O   1 
ATOM 1231 C CB  . ALA A 1 182 ? 182.792 193.156 143.974 1.00 95.13  ? 182 ALA R CB  1 
ATOM 1232 N N   . ASN A 1 183 ? 183.037 190.157 142.934 1.00 96.17  ? 183 ASN R N   1 
ATOM 1233 C CA  . ASN A 1 183 ? 182.605 188.764 142.972 1.00 96.17  ? 183 ASN R CA  1 
ATOM 1234 C C   . ASN A 1 183 ? 183.774 187.821 143.237 1.00 96.17  ? 183 ASN R C   1 
ATOM 1235 O O   . ASN A 1 183 ? 183.637 186.861 144.002 1.00 96.17  ? 183 ASN R O   1 
ATOM 1236 C CB  . ASN A 1 183 ? 181.901 188.401 141.666 1.00 96.17  ? 183 ASN R CB  1 
ATOM 1237 C CG  . ASN A 1 183 ? 180.603 189.160 141.474 1.00 96.17  ? 183 ASN R CG  1 
ATOM 1238 O OD1 . ASN A 1 183 ? 180.106 189.804 142.397 1.00 96.17  ? 183 ASN R OD1 1 
ATOM 1239 N ND2 . ASN A 1 183 ? 180.046 189.087 140.271 1.00 96.17  ? 183 ASN R ND2 1 
ATOM 1240 N N   . VAL A 1 184 ? 184.929 188.076 142.619 1.00 96.83  ? 184 VAL R N   1 
ATOM 1241 C CA  . VAL A 1 184 ? 186.103 187.241 142.863 1.00 96.83  ? 184 VAL R CA  1 
ATOM 1242 C C   . VAL A 1 184 ? 186.539 187.350 144.320 1.00 96.83  ? 184 VAL R C   1 
ATOM 1243 O O   . VAL A 1 184 ? 186.838 186.345 144.979 1.00 96.83  ? 184 VAL R O   1 
ATOM 1244 C CB  . VAL A 1 184 ? 187.244 187.625 141.905 1.00 96.83  ? 184 VAL R CB  1 
ATOM 1245 C CG1 . VAL A 1 184 ? 188.494 186.838 142.225 1.00 96.83  ? 184 VAL R CG1 1 
ATOM 1246 C CG2 . VAL A 1 184 ? 186.824 187.394 140.468 1.00 96.83  ? 184 VAL R CG2 1 
ATOM 1247 N N   . GLY A 1 185 ? 186.585 188.577 144.841 1.00 94.79  ? 185 GLY R N   1 
ATOM 1248 C CA  . GLY A 1 185 ? 186.944 188.759 146.235 1.00 94.79  ? 185 GLY R CA  1 
ATOM 1249 C C   . GLY A 1 185 ? 185.985 188.056 147.174 1.00 94.79  ? 185 GLY R C   1 
ATOM 1250 O O   . GLY A 1 185 ? 186.406 187.416 148.139 1.00 94.79  ? 185 GLY R O   1 
ATOM 1251 N N   . ARG A 1 186 ? 184.683 188.155 146.899 1.00 94.38  ? 186 ARG R N   1 
ATOM 1252 C CA  . ARG A 1 186 ? 183.700 187.473 147.731 1.00 94.38  ? 186 ARG R CA  1 
ATOM 1253 C C   . ARG A 1 186 ? 183.855 185.960 147.642 1.00 94.38  ? 186 ARG R C   1 
ATOM 1254 O O   . ARG A 1 186 ? 183.727 185.261 148.652 1.00 94.38  ? 186 ARG R O   1 
ATOM 1255 C CB  . ARG A 1 186 ? 182.289 187.894 147.326 1.00 30.00  ? 186 ARG R CB  1 
ATOM 1256 N N   . VAL A 1 187 ? 184.151 185.438 146.451 1.00 90.76  ? 187 VAL R N   1 
ATOM 1257 C CA  . VAL A 1 187 ? 184.293 183.995 146.284 1.00 90.76  ? 187 VAL R CA  1 
ATOM 1258 C C   . VAL A 1 187 ? 185.487 183.479 147.077 1.00 90.76  ? 187 VAL R C   1 
ATOM 1259 O O   . VAL A 1 187 ? 185.389 182.472 147.787 1.00 90.76  ? 187 VAL R O   1 
ATOM 1260 C CB  . VAL A 1 187 ? 184.409 183.635 144.792 1.00 90.76  ? 187 VAL R CB  1 
ATOM 1261 N N   . LEU A 1 188 ? 186.632 184.157 146.973 1.00 87.61  ? 188 LEU R N   1 
ATOM 1262 C CA  . LEU A 1 188 ? 187.810 183.694 147.705 1.00 87.61  ? 188 LEU R CA  1 
ATOM 1263 C C   . LEU A 1 188 ? 187.682 183.919 149.210 1.00 87.61  ? 188 LEU R C   1 
ATOM 1264 O O   . LEU A 1 188 ? 187.959 183.011 150.002 1.00 87.61  ? 188 LEU R O   1 
ATOM 1265 C CB  . LEU A 1 188 ? 189.086 184.342 147.164 1.00 87.61  ? 188 LEU R CB  1 
ATOM 1266 C CG  . LEU A 1 188 ? 189.682 183.789 145.862 1.00 87.61  ? 188 LEU R CG  1 
ATOM 1267 C CD1 . LEU A 1 188 ? 188.874 184.116 144.620 1.00 87.61  ? 188 LEU R CD1 1 
ATOM 1268 C CD2 . LEU A 1 188 ? 191.119 184.271 145.704 1.00 87.61  ? 188 LEU R CD2 1 
ATOM 1269 N N   . ALA A 1 189 ? 187.267 185.112 149.634 1.00 86.40  ? 189 ALA R N   1 
ATOM 1270 C CA  . ALA A 1 189 ? 187.344 185.496 151.036 1.00 86.40  ? 189 ALA R CA  1 
ATOM 1271 C C   . ALA A 1 189 ? 186.020 185.362 151.779 1.00 86.40  ? 189 ALA R C   1 
ATOM 1272 O O   . ALA A 1 189 ? 185.916 185.825 152.919 1.00 86.40  ? 189 ALA R O   1 
ATOM 1273 C CB  . ALA A 1 189 ? 187.861 186.930 151.158 1.00 86.40  ? 189 ALA R CB  1 
ATOM 1274 N N   . GLY A 1 190 ? 185.010 184.747 151.174 1.00 85.81  ? 190 GLY R N   1 
ATOM 1275 C CA  . GLY A 1 190 ? 183.761 184.540 151.875 1.00 85.81  ? 190 GLY R CA  1 
ATOM 1276 C C   . GLY A 1 190 ? 183.303 183.099 151.845 1.00 85.81  ? 190 GLY R C   1 
ATOM 1277 O O   . GLY A 1 190 ? 182.500 182.679 152.682 1.00 85.81  ? 190 GLY R O   1 
ATOM 1278 N N   . PHE A 1 191 ? 183.805 182.331 150.879 1.00 88.43  ? 191 PHE R N   1 
ATOM 1279 C CA  . PHE A 1 191 ? 183.513 180.904 150.801 1.00 88.43  ? 191 PHE R CA  1 
ATOM 1280 C C   . PHE A 1 191 ? 184.759 180.045 150.955 1.00 88.43  ? 191 PHE R C   1 
ATOM 1281 O O   . PHE A 1 191 ? 184.788 179.171 151.826 1.00 88.43  ? 191 PHE R O   1 
ATOM 1282 C CB  . PHE A 1 191 ? 182.803 180.572 149.485 1.00 88.43  ? 191 PHE R CB  1 
ATOM 1283 C CG  . PHE A 1 191 ? 182.313 179.156 149.414 1.00 88.43  ? 191 PHE R CG  1 
ATOM 1284 C CD1 . PHE A 1 191 ? 181.625 178.596 150.477 1.00 88.43  ? 191 PHE R CD1 1 
ATOM 1285 C CD2 . PHE A 1 191 ? 182.550 178.381 148.292 1.00 88.43  ? 191 PHE R CD2 1 
ATOM 1286 C CE1 . PHE A 1 191 ? 181.182 177.293 150.421 1.00 88.43  ? 191 PHE R CE1 1 
ATOM 1287 C CE2 . PHE A 1 191 ? 182.105 177.076 148.229 1.00 88.43  ? 191 PHE R CE2 1 
ATOM 1288 C CZ  . PHE A 1 191 ? 181.419 176.532 149.296 1.00 88.43  ? 191 PHE R CZ  1 
ATOM 1289 N N   . LEU A 1 192 ? 185.793 180.266 150.139 1.00 88.46  ? 192 LEU R N   1 
ATOM 1290 C CA  . LEU A 1 192 ? 186.922 179.340 150.108 1.00 88.46  ? 192 LEU R CA  1 
ATOM 1291 C C   . LEU A 1 192 ? 187.660 179.304 151.439 1.00 88.46  ? 192 LEU R C   1 
ATOM 1292 O O   . LEU A 1 192 ? 188.058 178.229 151.899 1.00 88.46  ? 192 LEU R O   1 
ATOM 1293 C CB  . LEU A 1 192 ? 187.879 179.706 148.976 1.00 88.46  ? 192 LEU R CB  1 
ATOM 1294 C CG  . LEU A 1 192 ? 187.336 179.548 147.557 1.00 88.46  ? 192 LEU R CG  1 
ATOM 1295 C CD1 . LEU A 1 192 ? 188.335 180.076 146.540 1.00 88.46  ? 192 LEU R CD1 1 
ATOM 1296 C CD2 . LEU A 1 192 ? 187.002 178.092 147.277 1.00 88.46  ? 192 LEU R CD2 1 
ATOM 1297 N N   . LEU A 1 193 ? 187.845 180.459 152.079 1.00 83.47  ? 193 LEU R N   1 
ATOM 1298 C CA  . LEU A 1 193 ? 188.593 180.467 153.335 1.00 83.47  ? 193 LEU R CA  1 
ATOM 1299 C C   . LEU A 1 193 ? 187.822 179.798 154.469 1.00 83.47  ? 193 LEU R C   1 
ATOM 1300 O O   . LEU A 1 193 ? 188.385 178.894 155.115 1.00 83.47  ? 193 LEU R O   1 
ATOM 1301 C CB  . LEU A 1 193 ? 189.017 181.899 153.681 1.00 83.47  ? 193 LEU R CB  1 
ATOM 1302 C CG  . LEU A 1 193 ? 190.090 182.057 154.758 1.00 83.47  ? 193 LEU R CG  1 
ATOM 1303 C CD1 . LEU A 1 193 ? 191.396 181.425 154.307 1.00 83.47  ? 193 LEU R CD1 1 
ATOM 1304 C CD2 . LEU A 1 193 ? 190.292 183.523 155.104 1.00 83.47  ? 193 LEU R CD2 1 
ATOM 1305 N N   . PRO A 1 194 ? 186.569 180.171 154.776 1.00 81.25  ? 194 PRO R N   1 
ATOM 1306 C CA  . PRO A 1 194 ? 185.846 179.436 155.832 1.00 81.25  ? 194 PRO R CA  1 
ATOM 1307 C C   . PRO A 1 194 ? 185.678 177.956 155.532 1.00 81.25  ? 194 PRO R C   1 
ATOM 1308 O O   . PRO A 1 194 ? 185.785 177.120 156.442 1.00 81.25  ? 194 PRO R O   1 
ATOM 1309 C CB  . PRO A 1 194 ? 184.490 180.153 155.901 1.00 81.25  ? 194 PRO R CB  1 
ATOM 1310 C CG  . PRO A 1 194 ? 184.705 181.472 155.292 1.00 81.25  ? 194 PRO R CG  1 
ATOM 1311 C CD  . PRO A 1 194 ? 185.781 181.308 154.269 1.00 81.25  ? 194 PRO R CD  1 
ATOM 1312 N N   . TRP A 1 195 ? 185.430 177.605 154.269 1.00 81.47  ? 195 TRP R N   1 
ATOM 1313 C CA  . TRP A 1 195 ? 185.206 176.204 153.933 1.00 81.47  ? 195 TRP R CA  1 
ATOM 1314 C C   . TRP A 1 195 ? 186.490 175.397 154.055 1.00 81.47  ? 195 TRP R C   1 
ATOM 1315 O O   . TRP A 1 195 ? 186.468 174.259 154.538 1.00 81.47  ? 195 TRP R O   1 
ATOM 1316 C CB  . TRP A 1 195 ? 184.620 176.087 152.529 1.00 81.47  ? 195 TRP R CB  1 
ATOM 1317 C CG  . TRP A 1 195 ? 184.323 174.683 152.126 1.00 81.47  ? 195 TRP R CG  1 
ATOM 1318 C CD1 . TRP A 1 195 ? 183.199 173.969 152.417 1.00 81.47  ? 195 TRP R CD1 1 
ATOM 1319 C CD2 . TRP A 1 195 ? 185.158 173.820 151.350 1.00 81.47  ? 195 TRP R CD2 1 
ATOM 1320 N NE1 . TRP A 1 195 ? 183.284 172.713 151.873 1.00 81.47  ? 195 TRP R NE1 1 
ATOM 1321 C CE2 . TRP A 1 195 ? 184.477 172.597 151.211 1.00 81.47  ? 195 TRP R CE2 1 
ATOM 1322 C CE3 . TRP A 1 195 ? 186.415 173.964 150.757 1.00 81.47  ? 195 TRP R CE3 1 
ATOM 1323 C CZ2 . TRP A 1 195 ? 185.010 171.523 150.505 1.00 81.47  ? 195 TRP R CZ2 1 
ATOM 1324 C CZ3 . TRP A 1 195 ? 186.943 172.896 150.057 1.00 81.47  ? 195 TRP R CZ3 1 
ATOM 1325 C CH2 . TRP A 1 195 ? 186.242 171.691 149.938 1.00 81.47  ? 195 TRP R CH2 1 
ATOM 1326 N N   . GLY A 1 196 ? 187.618 175.968 153.637 1.00 81.04  ? 196 GLY R N   1 
ATOM 1327 C CA  . GLY A 1 196 ? 188.890 175.300 153.847 1.00 81.04  ? 196 GLY R CA  1 
ATOM 1328 C C   . GLY A 1 196 ? 189.230 175.162 155.317 1.00 81.04  ? 196 GLY R C   1 
ATOM 1329 O O   . GLY A 1 196 ? 189.807 174.155 155.742 1.00 81.04  ? 196 GLY R O   1 
ATOM 1330 N N   . VAL A 1 197 ? 188.873 176.169 156.118 1.00 82.43  ? 197 VAL R N   1 
ATOM 1331 C CA  . VAL A 1 197 ? 189.093 176.065 157.556 1.00 82.43  ? 197 VAL R CA  1 
ATOM 1332 C C   . VAL A 1 197 ? 188.282 174.913 158.133 1.00 82.43  ? 197 VAL R C   1 
ATOM 1333 O O   . VAL A 1 197 ? 188.783 174.138 158.955 1.00 82.43  ? 197 VAL R O   1 
ATOM 1334 C CB  . VAL A 1 197 ? 188.773 177.397 158.255 1.00 82.43  ? 197 VAL R CB  1 
ATOM 1335 C CG1 . VAL A 1 197 ? 188.706 177.196 159.755 1.00 82.43  ? 197 VAL R CG1 1 
ATOM 1336 C CG2 . VAL A 1 197 ? 189.832 178.420 157.922 1.00 82.43  ? 197 VAL R CG2 1 
ATOM 1337 N N   . MET A 1 198 ? 187.021 174.775 157.712 1.00 80.05  ? 198 MET R N   1 
ATOM 1338 C CA  . MET A 1 198 ? 186.222 173.644 158.183 1.00 80.05  ? 198 MET R CA  1 
ATOM 1339 C C   . MET A 1 198 ? 186.812 172.312 157.725 1.00 80.05  ? 198 MET R C   1 
ATOM 1340 O O   . MET A 1 198 ? 186.859 171.349 158.503 1.00 80.05  ? 198 MET R O   1 
ATOM 1341 C CB  . MET A 1 198 ? 184.769 173.770 157.726 1.00 80.05  ? 198 MET R CB  1 
ATOM 1342 C CG  . MET A 1 198 ? 184.016 174.927 158.343 1.00 80.05  ? 198 MET R CG  1 
ATOM 1343 S SD  . MET A 1 198 ? 182.288 174.987 157.828 1.00 80.05  ? 198 MET R SD  1 
ATOM 1344 C CE  . MET A 1 198 ? 182.440 175.580 156.148 1.00 80.05  ? 198 MET R CE  1 
ATOM 1345 N N   . MET A 1 199 ? 187.242 172.230 156.461 1.00 73.31  ? 199 MET R N   1 
ATOM 1346 C CA  . MET A 1 199 ? 187.969 171.059 155.973 1.00 73.31  ? 199 MET R CA  1 
ATOM 1347 C C   . MET A 1 199 ? 189.077 170.656 156.933 1.00 73.31  ? 199 MET R C   1 
ATOM 1348 O O   . MET A 1 199 ? 189.075 169.549 157.488 1.00 73.31  ? 199 MET R O   1 
ATOM 1349 C CB  . MET A 1 199 ? 188.573 171.338 154.592 1.00 73.31  ? 199 MET R CB  1 
ATOM 1350 C CG  . MET A 1 199 ? 187.602 171.539 153.449 1.00 73.31  ? 199 MET R CG  1 
ATOM 1351 S SD  . MET A 1 199 ? 186.607 170.072 153.147 1.00 73.31  ? 199 MET R SD  1 
ATOM 1352 C CE  . MET A 1 199 ? 185.077 170.564 153.912 1.00 73.31  ? 199 MET R CE  1 
ATOM 1353 N N   . LEU A 1 200 ? 190.040 171.557 157.125 1.00 79.80  ? 200 LEU R N   1 
ATOM 1354 C CA  . LEU A 1 200 ? 191.203 171.238 157.944 1.00 79.80  ? 200 LEU R CA  1 
ATOM 1355 C C   . LEU A 1 200 ? 190.800 170.906 159.373 1.00 79.80  ? 200 LEU R C   1 
ATOM 1356 O O   . LEU A 1 200 ? 191.340 169.971 159.973 1.00 79.80  ? 200 LEU R O   1 
ATOM 1357 C CB  . LEU A 1 200 ? 192.203 172.395 157.921 1.00 79.80  ? 200 LEU R CB  1 
ATOM 1358 C CG  . LEU A 1 200 ? 193.195 172.505 156.757 1.00 79.80  ? 200 LEU R CG  1 
ATOM 1359 C CD1 . LEU A 1 200 ? 194.134 171.307 156.756 1.00 79.80  ? 200 LEU R CD1 1 
ATOM 1360 C CD2 . LEU A 1 200 ? 192.516 172.643 155.404 1.00 79.80  ? 200 LEU R CD2 1 
ATOM 1361 N N   . CYS A 1 201 ? 189.841 171.646 159.929 1.00 75.40  ? 201 CYS R N   1 
ATOM 1362 C CA  . CYS A 1 201 ? 189.488 171.470 161.332 1.00 75.40  ? 201 CYS R CA  1 
ATOM 1363 C C   . CYS A 1 201 ? 188.838 170.114 161.575 1.00 75.40  ? 201 CYS R C   1 
ATOM 1364 O O   . CYS A 1 201 ? 189.214 169.394 162.509 1.00 75.40  ? 201 CYS R O   1 
ATOM 1365 C CB  . CYS A 1 201 ? 188.569 172.605 161.778 1.00 75.40  ? 201 CYS R CB  1 
ATOM 1366 S SG  . CYS A 1 201 ? 189.447 174.120 162.208 1.00 75.40  ? 201 CYS R SG  1 
ATOM 1367 N N   . TYR A 1 202 ? 187.864 169.737 160.745 1.00 76.14  ? 202 TYR R N   1 
ATOM 1368 C CA  . TYR A 1 202 ? 187.217 168.445 160.947 1.00 76.14  ? 202 TYR R CA  1 
ATOM 1369 C C   . TYR A 1 202 ? 188.140 167.285 160.585 1.00 76.14  ? 202 TYR R C   1 
ATOM 1370 O O   . TYR A 1 202 ? 188.088 166.230 161.235 1.00 76.14  ? 202 TYR R O   1 
ATOM 1371 C CB  . TYR A 1 202 ? 185.912 168.384 160.161 1.00 76.14  ? 202 TYR R CB  1 
ATOM 1372 C CG  . TYR A 1 202 ? 184.789 169.149 160.822 1.00 76.14  ? 202 TYR R CG  1 
ATOM 1373 C CD1 . TYR A 1 202 ? 184.467 168.934 162.153 1.00 76.14  ? 202 TYR R CD1 1 
ATOM 1374 C CD2 . TYR A 1 202 ? 184.059 170.095 160.120 1.00 76.14  ? 202 TYR R CD2 1 
ATOM 1375 C CE1 . TYR A 1 202 ? 183.443 169.630 162.762 1.00 76.14  ? 202 TYR R CE1 1 
ATOM 1376 C CE2 . TYR A 1 202 ? 183.033 170.796 160.720 1.00 76.14  ? 202 TYR R CE2 1 
ATOM 1377 C CZ  . TYR A 1 202 ? 182.730 170.562 162.042 1.00 76.14  ? 202 TYR R CZ  1 
ATOM 1378 O OH  . TYR A 1 202 ? 181.711 171.260 162.643 1.00 76.14  ? 202 TYR R OH  1 
ATOM 1379 N N   . ALA A 1 203 ? 189.006 167.456 159.580 1.00 72.97  ? 203 ALA R N   1 
ATOM 1380 C CA  . ALA A 1 203 ? 190.000 166.423 159.304 1.00 72.97  ? 203 ALA R CA  1 
ATOM 1381 C C   . ALA A 1 203 ? 190.925 166.224 160.497 1.00 72.97  ? 203 ALA R C   1 
ATOM 1382 O O   . ALA A 1 203 ? 191.230 165.085 160.875 1.00 72.97  ? 203 ALA R O   1 
ATOM 1383 C CB  . ALA A 1 203 ? 190.802 166.784 158.056 1.00 72.97  ? 203 ALA R CB  1 
ATOM 1384 N N   . GLY A 1 204 ? 191.373 167.321 161.113 1.00 73.83  ? 204 GLY R N   1 
ATOM 1385 C CA  . GLY A 1 204 ? 192.183 167.210 162.311 1.00 73.83  ? 204 GLY R CA  1 
ATOM 1386 C C   . GLY A 1 204 ? 191.438 166.584 163.471 1.00 73.83  ? 204 GLY R C   1 
ATOM 1387 O O   . GLY A 1 204 ? 192.028 165.857 164.271 1.00 73.83  ? 204 GLY R O   1 
ATOM 1388 N N   . LEU A 1 205 ? 190.137 166.857 163.581 1.00 77.33  ? 205 LEU R N   1 
ATOM 1389 C CA  . LEU A 1 205 ? 189.333 166.235 164.627 1.00 77.33  ? 205 LEU R CA  1 
ATOM 1390 C C   . LEU A 1 205 ? 189.299 164.720 164.462 1.00 77.33  ? 205 LEU R C   1 
ATOM 1391 O O   . LEU A 1 205 ? 189.507 163.970 165.427 1.00 77.33  ? 205 LEU R O   1 
ATOM 1392 C CB  . LEU A 1 205 ? 187.920 166.817 164.607 1.00 77.33  ? 205 LEU R CB  1 
ATOM 1393 C CG  . LEU A 1 205 ? 186.971 166.492 165.758 1.00 77.33  ? 205 LEU R CG  1 
ATOM 1394 C CD1 . LEU A 1 205 ? 186.090 167.692 166.044 1.00 77.33  ? 205 LEU R CD1 1 
ATOM 1395 C CD2 . LEU A 1 205 ? 186.116 165.274 165.444 1.00 77.33  ? 205 LEU R CD2 1 
ATOM 1396 N N   . LEU A 1 206 ? 189.043 164.249 163.239 1.00 78.87  ? 206 LEU R N   1 
ATOM 1397 C CA  . LEU A 1 206 ? 189.070 162.808 162.996 1.00 78.87  ? 206 LEU R CA  1 
ATOM 1398 C C   . LEU A 1 206 ? 190.454 162.226 163.247 1.00 78.87  ? 206 LEU R C   1 
ATOM 1399 O O   . LEU A 1 206 ? 190.580 161.126 163.796 1.00 78.87  ? 206 LEU R O   1 
ATOM 1400 C CB  . LEU A 1 206 ? 188.609 162.479 161.577 1.00 78.87  ? 206 LEU R CB  1 
ATOM 1401 C CG  . LEU A 1 206 ? 187.113 162.374 161.289 1.00 78.87  ? 206 LEU R CG  1 
ATOM 1402 C CD1 . LEU A 1 206 ? 186.512 161.216 162.070 1.00 78.87  ? 206 LEU R CD1 1 
ATOM 1403 C CD2 . LEU A 1 206 ? 186.389 163.651 161.612 1.00 78.87  ? 206 LEU R CD2 1 
ATOM 1404 N N   . ARG A 1 207 ? 191.507 162.945 162.855 1.00 77.75  ? 207 ARG R N   1 
ATOM 1405 C CA  . ARG A 1 207 ? 192.852 162.420 163.057 1.00 77.75  ? 207 ARG R CA  1 
ATOM 1406 C C   . ARG A 1 207 ? 193.210 162.353 164.537 1.00 77.75  ? 207 ARG R C   1 
ATOM 1407 O O   . ARG A 1 207 ? 193.953 161.458 164.955 1.00 77.75  ? 207 ARG R O   1 
ATOM 1408 C CB  . ARG A 1 207 ? 193.863 163.268 162.289 1.00 77.75  ? 207 ARG R CB  1 
ATOM 1409 C CG  . ARG A 1 207 ? 195.295 162.773 162.385 1.00 77.75  ? 207 ARG R CG  1 
ATOM 1410 C CD  . ARG A 1 207 ? 195.447 161.415 161.719 1.00 77.75  ? 207 ARG R CD  1 
ATOM 1411 N NE  . ARG A 1 207 ? 195.088 161.455 160.304 1.00 77.75  ? 207 ARG R NE  1 
ATOM 1412 C CZ  . ARG A 1 207 ? 195.916 161.824 159.331 1.00 77.75  ? 207 ARG R CZ  1 
ATOM 1413 N NH1 . ARG A 1 207 ? 197.159 162.186 159.616 1.00 77.75  ? 207 ARG R NH1 1 
ATOM 1414 N NH2 . ARG A 1 207 ? 195.500 161.829 158.072 1.00 77.75  ? 207 ARG R NH2 1 
ATOM 1415 N N   . ALA A 1 208 ? 192.690 163.282 165.342 1.00 78.80  ? 208 ALA R N   1 
ATOM 1416 C CA  . ALA A 1 208 ? 192.926 163.257 166.780 1.00 78.80  ? 208 ALA R CA  1 
ATOM 1417 C C   . ALA A 1 208 ? 192.092 162.195 167.481 1.00 78.80  ? 208 ALA R C   1 
ATOM 1418 O O   . ALA A 1 208 ? 192.508 161.678 168.523 1.00 78.80  ? 208 ALA R O   1 
ATOM 1419 C CB  . ALA A 1 208 ? 192.638 164.631 167.385 1.00 78.80  ? 208 ALA R CB  1 
ATOM 1420 N N   . LEU A 1 209 ? 190.922 161.861 166.936 1.00 79.34  ? 209 LEU R N   1 
ATOM 1421 C CA  . LEU A 1 209 ? 190.092 160.821 167.535 1.00 79.34  ? 209 LEU R CA  1 
ATOM 1422 C C   . LEU A 1 209 ? 190.668 159.422 167.365 1.00 79.34  ? 209 LEU R C   1 
ATOM 1423 O O   . LEU A 1 209 ? 190.125 158.476 167.946 1.00 79.34  ? 209 LEU R O   1 
ATOM 1424 C CB  . LEU A 1 209 ? 188.684 160.859 166.941 1.00 30.00  ? 209 LEU R CB  1 
ATOM 1425 C CG  . LEU A 1 209 ? 187.682 161.811 167.588 1.00 30.00  ? 209 LEU R CG  1 
ATOM 1426 C CD1 . LEU A 1 209 ? 186.290 161.566 167.040 1.00 30.00  ? 209 LEU R CD1 1 
ATOM 1427 C CD2 . LEU A 1 209 ? 187.699 161.647 169.096 1.00 30.00  ? 209 LEU R CD2 1 
ATOM 1428 N N   . ARG A 1 210 ? 191.740 159.265 166.587 1.00 79.16  ? 210 ARG R N   1 
ATOM 1429 C CA  . ARG A 1 210 ? 192.200 157.934 166.205 1.00 79.16  ? 210 ARG R CA  1 
ATOM 1430 C C   . ARG A 1 210 ? 192.759 157.158 167.392 1.00 79.16  ? 210 ARG R C   1 
ATOM 1431 O O   . ARG A 1 210 ? 192.573 155.940 167.483 1.00 79.16  ? 210 ARG R O   1 
ATOM 1432 C CB  . ARG A 1 210 ? 193.251 158.050 165.103 1.00 79.16  ? 210 ARG R CB  1 
ATOM 1433 C CG  . ARG A 1 210 ? 193.185 156.952 164.065 1.00 79.16  ? 210 ARG R CG  1 
ATOM 1434 C CD  . ARG A 1 210 ? 194.242 157.161 162.995 1.00 79.16  ? 210 ARG R CD  1 
ATOM 1435 N NE  . ARG A 1 210 ? 193.812 158.133 161.997 1.00 79.16  ? 210 ARG R NE  1 
ATOM 1436 C CZ  . ARG A 1 210 ? 192.917 157.887 161.046 1.00 79.16  ? 210 ARG R CZ  1 
ATOM 1437 N NH1 . ARG A 1 210 ? 192.354 156.690 160.953 1.00 79.16  ? 210 ARG R NH1 1 
ATOM 1438 N NH2 . ARG A 1 210 ? 192.587 158.837 160.183 1.00 79.16  ? 210 ARG R NH2 1 
ATOM 1439 N N   . GLY A 1 211 ? 193.454 157.833 168.301 1.00 76.34  ? 211 GLY R N   1 
ATOM 1440 C CA  . GLY A 1 211 ? 194.099 157.143 169.400 1.00 76.34  ? 211 GLY R CA  1 
ATOM 1441 C C   . GLY A 1 211 ? 193.244 156.880 170.617 1.00 76.34  ? 211 GLY R C   1 
ATOM 1442 O O   . GLY A 1 211 ? 193.707 156.221 171.552 1.00 76.34  ? 211 GLY R O   1 
ATOM 1443 N N   . SER A 1 212 ? 192.008 157.375 170.636 1.00 77.25  ? 212 SER R N   1 
ATOM 1444 C CA  . SER A 1 212 ? 191.146 157.219 171.800 1.00 77.25  ? 212 SER R CA  1 
ATOM 1445 C C   . SER A 1 212 ? 190.891 155.751 172.111 1.00 77.25  ? 212 SER R C   1 
ATOM 1446 O O   . SER A 1 212 ? 190.224 155.052 171.342 1.00 77.25  ? 212 SER R O   1 
ATOM 1447 C CB  . SER A 1 212 ? 189.821 157.948 171.585 1.00 77.25  ? 212 SER R CB  1 
ATOM 1448 O OG  . SER A 1 212 ? 189.010 157.877 172.744 1.00 77.25  ? 212 SER R OG  1 
ATOM 1449 N N   . ALA A 1 213 ? 191.424 155.277 173.240 1.00 85.46  ? 213 ALA R N   1 
ATOM 1450 C CA  . ALA A 1 213 ? 191.150 153.916 173.684 1.00 85.46  ? 213 ALA R CA  1 
ATOM 1451 C C   . ALA A 1 213 ? 189.698 153.729 174.088 1.00 85.46  ? 213 ALA R C   1 
ATOM 1452 O O   . ALA A 1 213 ? 189.241 152.588 174.210 1.00 85.46  ? 213 ALA R O   1 
ATOM 1453 C CB  . ALA A 1 213 ? 192.065 153.551 174.852 1.00 85.46  ? 213 ALA R CB  1 
ATOM 1454 N N   . SER A 1 214 ? 188.967 154.824 174.299 1.00 88.27  ? 214 SER R N   1 
ATOM 1455 C CA  . SER A 1 214 ? 187.643 154.760 174.904 1.00 88.27  ? 214 SER R CA  1 
ATOM 1456 C C   . SER A 1 214 ? 186.570 154.393 173.886 1.00 88.27  ? 214 SER R C   1 
ATOM 1457 O O   . SER A 1 214 ? 185.905 153.359 174.012 1.00 88.27  ? 214 SER R O   1 
ATOM 1458 C CB  . SER A 1 214 ? 187.315 156.100 175.563 1.00 88.27  ? 214 SER R CB  1 
ATOM 1459 O OG  . SER A 1 214 ? 188.212 156.384 176.620 1.00 88.27  ? 214 SER R OG  1 
ATOM 1460 N N   . CYS A 1 215 ? 186.391 155.231 172.870 1.00 97.45  ? 215 CYS R N   1 
ATOM 1461 C CA  . CYS A 1 215 ? 185.280 155.073 171.944 1.00 97.45  ? 215 CYS R CA  1 
ATOM 1462 C C   . CYS A 1 215 ? 185.500 153.888 171.013 1.00 97.45  ? 215 CYS R C   1 
ATOM 1463 O O   . CYS A 1 215 ? 186.593 153.691 170.477 1.00 97.45  ? 215 CYS R O   1 
ATOM 1464 C CB  . CYS A 1 215 ? 185.082 156.354 171.133 1.00 97.45  ? 215 CYS R CB  1 
ATOM 1465 S SG  . CYS A 1 215 ? 186.571 156.983 170.337 1.00 97.45  ? 215 CYS R SG  1 
ATOM 1466 N N   . GLU A 1 216 ? 184.448 153.097 170.831 1.00 96.79  ? 216 GLU R N   1 
ATOM 1467 C CA  . GLU A 1 216 ? 184.483 151.947 169.940 1.00 96.79  ? 216 GLU R CA  1 
ATOM 1468 C C   . GLU A 1 216 ? 184.275 152.420 168.505 1.00 96.79  ? 216 GLU R C   1 
ATOM 1469 O O   . GLU A 1 216 ? 184.306 153.617 168.207 1.00 96.79  ? 216 GLU R O   1 
ATOM 1470 C CB  . GLU A 1 216 ? 183.431 150.922 170.356 1.00 96.79  ? 216 GLU R CB  1 
ATOM 1471 C CG  . GLU A 1 216 ? 183.790 150.120 171.595 1.00 96.79  ? 216 GLU R CG  1 
ATOM 1472 C CD  . GLU A 1 216 ? 183.262 150.753 172.865 1.00 96.79  ? 216 GLU R CD  1 
ATOM 1473 O OE1 . GLU A 1 216 ? 183.795 150.445 173.951 1.00 96.79  ? 216 GLU R OE1 1 
ATOM 1474 O OE2 . GLU A 1 216 ? 182.314 151.561 172.778 1.00 96.79  ? 216 GLU R OE2 1 
ATOM 1475 N N   . GLN A 1 217 ? 184.063 151.474 167.589 1.00 97.24  ? 217 GLN R N   1 
ATOM 1476 C CA  . GLN A 1 217 ? 183.751 151.850 166.216 1.00 97.24  ? 217 GLN R CA  1 
ATOM 1477 C C   . GLN A 1 217 ? 182.411 152.564 166.131 1.00 97.24  ? 217 GLN R C   1 
ATOM 1478 O O   . GLN A 1 217 ? 182.222 153.432 165.271 1.00 97.24  ? 217 GLN R O   1 
ATOM 1479 C CB  . GLN A 1 217 ? 183.758 150.615 165.316 1.00 97.24  ? 217 GLN R CB  1 
ATOM 1480 C CG  . GLN A 1 217 ? 183.043 149.413 165.904 1.00 97.24  ? 217 GLN R CG  1 
ATOM 1481 C CD  . GLN A 1 217 ? 183.283 148.148 165.106 1.00 97.24  ? 217 GLN R CD  1 
ATOM 1482 O OE1 . GLN A 1 217 ? 183.830 148.190 164.005 1.00 97.24  ? 217 GLN R OE1 1 
ATOM 1483 N NE2 . GLN A 1 217 ? 182.876 147.013 165.659 1.00 97.24  ? 217 GLN R NE2 1 
ATOM 1484 N N   . ARG A 1 218 ? 181.481 152.231 167.030 1.00 101.10 ? 218 ARG R N   1 
ATOM 1485 C CA  . ARG A 1 218 ? 180.150 152.820 166.992 1.00 101.10 ? 218 ARG R CA  1 
ATOM 1486 C C   . ARG A 1 218 ? 180.159 154.304 167.320 1.00 101.10 ? 218 ARG R C   1 
ATOM 1487 O O   . ARG A 1 218 ? 179.204 155.005 166.971 1.00 101.10 ? 218 ARG R O   1 
ATOM 1488 C CB  . ARG A 1 218 ? 179.221 152.081 167.954 1.00 101.10 ? 218 ARG R CB  1 
ATOM 1489 C CG  . ARG A 1 218 ? 179.169 150.580 167.738 1.00 101.10 ? 218 ARG R CG  1 
ATOM 1490 C CD  . ARG A 1 218 ? 178.477 150.227 166.433 1.00 101.10 ? 218 ARG R CD  1 
ATOM 1491 N NE  . ARG A 1 218 ? 177.026 150.341 166.538 1.00 101.10 ? 218 ARG R NE  1 
ATOM 1492 C CZ  . ARG A 1 218 ? 176.179 150.020 165.566 1.00 101.10 ? 218 ARG R CZ  1 
ATOM 1493 N NH1 . ARG A 1 218 ? 176.637 149.561 164.409 1.00 101.10 ? 218 ARG R NH1 1 
ATOM 1494 N NH2 . ARG A 1 218 ? 174.873 150.156 165.750 1.00 101.10 ? 218 ARG R NH2 1 
ATOM 1495 N N   . GLU A 1 219 ? 181.205 154.802 167.974 1.00 96.84  ? 219 GLU R N   1 
ATOM 1496 C CA  . GLU A 1 219 ? 181.325 156.232 168.221 1.00 96.84  ? 219 GLU R CA  1 
ATOM 1497 C C   . GLU A 1 219 ? 182.244 156.927 167.230 1.00 96.84  ? 219 GLU R C   1 
ATOM 1498 O O   . GLU A 1 219 ? 181.954 158.059 166.822 1.00 96.84  ? 219 GLU R O   1 
ATOM 1499 C CB  . GLU A 1 219 ? 181.830 156.489 169.644 1.00 96.84  ? 219 GLU R CB  1 
ATOM 1500 C CG  . GLU A 1 219 ? 180.874 156.032 170.733 1.00 96.84  ? 219 GLU R CG  1 
ATOM 1501 C CD  . GLU A 1 219 ? 179.573 156.808 170.731 1.00 96.84  ? 219 GLU R CD  1 
ATOM 1502 O OE1 . GLU A 1 219 ? 179.597 158.013 170.404 1.00 96.84  ? 219 GLU R OE1 1 
ATOM 1503 O OE2 . GLU A 1 219 ? 178.524 156.213 171.057 1.00 96.84  ? 219 GLU R OE2 1 
ATOM 1504 N N   . ARG A 1 220 ? 183.332 156.273 166.818 1.00 94.07  ? 220 ARG R N   1 
ATOM 1505 C CA  . ARG A 1 220 ? 184.200 156.867 165.809 1.00 94.07  ? 220 ARG R CA  1 
ATOM 1506 C C   . ARG A 1 220 ? 183.463 157.052 164.493 1.00 94.07  ? 220 ARG R C   1 
ATOM 1507 O O   . ARG A 1 220 ? 183.589 158.098 163.848 1.00 94.07  ? 220 ARG R O   1 
ATOM 1508 C CB  . ARG A 1 220 ? 185.450 156.013 165.600 1.00 94.07  ? 220 ARG R CB  1 
ATOM 1509 C CG  . ARG A 1 220 ? 186.404 156.000 166.780 1.00 94.07  ? 220 ARG R CG  1 
ATOM 1510 C CD  . ARG A 1 220 ? 187.706 155.307 166.420 1.00 94.07  ? 220 ARG R CD  1 
ATOM 1511 N NE  . ARG A 1 220 ? 187.515 153.896 166.100 1.00 94.07  ? 220 ARG R NE  1 
ATOM 1512 C CZ  . ARG A 1 220 ? 187.535 152.915 166.997 1.00 94.07  ? 220 ARG R CZ  1 
ATOM 1513 N NH1 . ARG A 1 220 ? 187.739 153.188 168.278 1.00 94.07  ? 220 ARG R NH1 1 
ATOM 1514 N NH2 . ARG A 1 220 ? 187.352 151.660 166.611 1.00 94.07  ? 220 ARG R NH2 1 
ATOM 1515 N N   . ARG A 1 221 ? 182.680 156.056 164.079 1.00 94.67  ? 221 ARG R N   1 
ATOM 1516 C CA  . ARG A 1 221 ? 181.963 156.196 162.819 1.00 94.67  ? 221 ARG R CA  1 
ATOM 1517 C C   . ARG A 1 221 ? 180.853 157.232 162.919 1.00 94.67  ? 221 ARG R C   1 
ATOM 1518 O O   . ARG A 1 221 ? 180.573 157.927 161.938 1.00 94.67  ? 221 ARG R O   1 
ATOM 1519 C CB  . ARG A 1 221 ? 181.416 154.841 162.366 1.00 94.67  ? 221 ARG R CB  1 
ATOM 1520 C CG  . ARG A 1 221 ? 180.104 154.431 162.996 1.00 94.67  ? 221 ARG R CG  1 
ATOM 1521 C CD  . ARG A 1 221 ? 179.446 153.332 162.186 1.00 94.67  ? 221 ARG R CD  1 
ATOM 1522 N NE  . ARG A 1 221 ? 180.247 152.113 162.180 1.00 94.67  ? 221 ARG R NE  1 
ATOM 1523 C CZ  . ARG A 1 221 ? 179.774 150.908 161.889 1.00 94.67  ? 221 ARG R CZ  1 
ATOM 1524 N NH1 . ARG A 1 221 ? 178.496 150.754 161.576 1.00 94.67  ? 221 ARG R NH1 1 
ATOM 1525 N NH2 . ARG A 1 221 ? 180.578 149.856 161.911 1.00 94.67  ? 221 ARG R NH2 1 
ATOM 1526 N N   . ARG A 1 222 ? 180.224 157.371 164.089 1.00 93.02  ? 222 ARG R N   1 
ATOM 1527 C CA  . ARG A 1 222 ? 179.230 158.424 164.262 1.00 93.02  ? 222 ARG R CA  1 
ATOM 1528 C C   . ARG A 1 222 ? 179.872 159.802 164.160 1.00 93.02  ? 222 ARG R C   1 
ATOM 1529 O O   . ARG A 1 222 ? 179.339 160.700 163.493 1.00 93.02  ? 222 ARG R O   1 
ATOM 1530 C CB  . ARG A 1 222 ? 178.513 158.256 165.600 1.00 93.02  ? 222 ARG R CB  1 
ATOM 1531 N N   . VAL A 1 223 ? 181.032 159.983 164.795 1.00 95.39  ? 223 VAL R N   1 
ATOM 1532 C CA  . VAL A 1 223 ? 181.742 161.252 164.675 1.00 95.39  ? 223 VAL R CA  1 
ATOM 1533 C C   . VAL A 1 223 ? 182.214 161.468 163.244 1.00 95.39  ? 223 VAL R C   1 
ATOM 1534 O O   . VAL A 1 223 ? 182.341 162.611 162.791 1.00 95.39  ? 223 VAL R O   1 
ATOM 1535 C CB  . VAL A 1 223 ? 182.914 161.309 165.670 1.00 95.39  ? 223 VAL R CB  1 
ATOM 1536 N N   . ARG A 1 224 ? 182.475 160.386 162.511 1.00 91.33  ? 224 ARG R N   1 
ATOM 1537 C CA  . ARG A 1 224 ? 182.883 160.506 161.116 1.00 91.33  ? 224 ARG R CA  1 
ATOM 1538 C C   . ARG A 1 224 ? 181.725 160.966 160.237 1.00 91.33  ? 224 ARG R C   1 
ATOM 1539 O O   . ARG A 1 224 ? 181.913 161.798 159.342 1.00 91.33  ? 224 ARG R O   1 
ATOM 1540 C CB  . ARG A 1 224 ? 183.439 159.170 160.631 1.00 91.33  ? 224 ARG R CB  1 
ATOM 1541 C CG  . ARG A 1 224 ? 184.049 159.188 159.248 1.00 91.33  ? 224 ARG R CG  1 
ATOM 1542 C CD  . ARG A 1 224 ? 184.799 157.897 159.001 1.00 91.33  ? 224 ARG R CD  1 
ATOM 1543 N NE  . ARG A 1 224 ? 184.561 157.355 157.670 1.00 91.33  ? 224 ARG R NE  1 
ATOM 1544 C CZ  . ARG A 1 224 ? 185.449 157.392 156.683 1.00 91.33  ? 224 ARG R CZ  1 
ATOM 1545 N NH1 . ARG A 1 224 ? 186.637 157.944 156.879 1.00 91.33  ? 224 ARG R NH1 1 
ATOM 1546 N NH2 . ARG A 1 224 ? 185.150 156.875 155.500 1.00 91.33  ? 224 ARG R NH2 1 
ATOM 1547 N N   . ARG A 1 225 ? 180.524 160.427 160.469 1.00 92.12  ? 225 ARG R N   1 
ATOM 1548 C CA  . ARG A 1 225 ? 179.349 160.933 159.763 1.00 92.12  ? 225 ARG R CA  1 
ATOM 1549 C C   . ARG A 1 225 ? 179.098 162.395 160.103 1.00 92.12  ? 225 ARG R C   1 
ATOM 1550 O O   . ARG A 1 225 ? 178.786 163.201 159.219 1.00 92.12  ? 225 ARG R O   1 
ATOM 1551 C CB  . ARG A 1 225 ? 178.102 160.107 160.090 1.00 92.12  ? 225 ARG R CB  1 
ATOM 1552 C CG  . ARG A 1 225 ? 178.282 158.603 160.159 1.00 92.12  ? 225 ARG R CG  1 
ATOM 1553 C CD  . ARG A 1 225 ? 178.096 157.935 158.811 1.00 92.12  ? 225 ARG R CD  1 
ATOM 1554 N NE  . ARG A 1 225 ? 177.835 156.505 158.952 1.00 92.12  ? 225 ARG R NE  1 
ATOM 1555 C CZ  . ARG A 1 225 ? 178.427 155.556 158.233 1.00 92.12  ? 225 ARG R CZ  1 
ATOM 1556 N NH1 . ARG A 1 225 ? 179.322 155.881 157.314 1.00 92.12  ? 225 ARG R NH1 1 
ATOM 1557 N NH2 . ARG A 1 225 ? 178.121 154.281 158.433 1.00 92.12  ? 225 ARG R NH2 1 
ATOM 1558 N N   . LEU A 1 226 ? 179.221 162.756 161.383 1.00 90.00  ? 226 LEU R N   1 
ATOM 1559 C CA  . LEU A 1 226 ? 178.932 164.128 161.793 1.00 90.00  ? 226 LEU R CA  1 
ATOM 1560 C C   . LEU A 1 226 ? 179.932 165.116 161.200 1.00 90.00  ? 226 LEU R C   1 
ATOM 1561 O O   . LEU A 1 226 ? 179.542 166.158 160.662 1.00 90.00  ? 226 LEU R O   1 
ATOM 1562 C CB  . LEU A 1 226 ? 178.914 164.233 163.319 1.00 90.00  ? 226 LEU R CB  1 
ATOM 1563 C CG  . LEU A 1 226 ? 177.560 164.091 164.022 1.00 90.00  ? 226 LEU R CG  1 
ATOM 1564 C CD1 . LEU A 1 226 ? 176.644 165.234 163.624 1.00 90.00  ? 226 LEU R CD1 1 
ATOM 1565 C CD2 . LEU A 1 226 ? 176.905 162.752 163.721 1.00 90.00  ? 226 LEU R CD2 1 
ATOM 1566 N N   . ALA A 1 227 ? 181.223 164.807 161.283 1.00 86.56  ? 227 ALA R N   1 
ATOM 1567 C CA  . ALA A 1 227 ? 182.257 165.760 160.906 1.00 86.56  ? 227 ALA R CA  1 
ATOM 1568 C C   . ALA A 1 227 ? 182.648 165.685 159.437 1.00 86.56  ? 227 ALA R C   1 
ATOM 1569 O O   . ALA A 1 227 ? 183.435 166.520 158.981 1.00 86.56  ? 227 ALA R O   1 
ATOM 1570 C CB  . ALA A 1 227 ? 183.496 165.561 161.779 1.00 86.56  ? 227 ALA R CB  1 
ATOM 1571 N N   . LEU A 1 228 ? 182.132 164.712 158.689 1.00 90.87  ? 228 LEU R N   1 
ATOM 1572 C CA  . LEU A 1 228 ? 182.258 164.693 157.236 1.00 90.87  ? 228 LEU R CA  1 
ATOM 1573 C C   . LEU A 1 228 ? 180.887 164.714 156.573 1.00 90.87  ? 228 LEU R C   1 
ATOM 1574 O O   . LEU A 1 228 ? 180.737 164.300 155.423 1.00 90.87  ? 228 LEU R O   1 
ATOM 1575 C CB  . LEU A 1 228 ? 183.068 163.487 156.762 1.00 90.87  ? 228 LEU R CB  1 
ATOM 1576 C CG  . LEU A 1 228 ? 184.593 163.626 156.775 1.00 90.87  ? 228 LEU R CG  1 
ATOM 1577 C CD1 . LEU A 1 228 ? 185.150 163.523 158.186 1.00 90.87  ? 228 LEU R CD1 1 
ATOM 1578 C CD2 . LEU A 1 228 ? 185.237 162.596 155.861 1.00 90.87  ? 228 LEU R CD2 1 
ATOM 1579 N N   . GLY A 1 229 ? 179.877 165.189 157.295 1.00 91.45  ? 229 GLY R N   1 
ATOM 1580 C CA  . GLY A 1 229 ? 178.547 165.326 156.742 1.00 91.45  ? 229 GLY R CA  1 
ATOM 1581 C C   . GLY A 1 229 ? 178.037 166.747 156.826 1.00 91.45  ? 229 GLY R C   1 
ATOM 1582 O O   . GLY A 1 229 ? 177.202 167.163 156.018 1.00 91.45  ? 229 GLY R O   1 
ATOM 1583 N N   . LEU A 1 230 ? 178.539 167.505 157.793 1.00 92.25  ? 230 LEU R N   1 
ATOM 1584 C CA  . LEU A 1 230 ? 178.176 168.909 157.944 1.00 92.25  ? 230 LEU R CA  1 
ATOM 1585 C C   . LEU A 1 230 ? 178.912 169.764 156.913 1.00 92.25  ? 230 LEU R C   1 
ATOM 1586 O O   . LEU A 1 230 ? 178.281 170.607 156.258 1.00 92.25  ? 230 LEU R O   1 
ATOM 1587 C CB  . LEU A 1 230 ? 178.464 169.398 159.369 1.00 92.25  ? 230 LEU R CB  1 
ATOM 1588 C CG  . LEU A 1 230 ? 177.392 169.240 160.451 1.00 92.25  ? 230 LEU R CG  1 
ATOM 1589 C CD1 . LEU A 1 230 ? 176.736 167.868 160.416 1.00 92.25  ? 230 LEU R CD1 1 
ATOM 1590 C CD2 . LEU A 1 230 ? 177.994 169.505 161.819 1.00 92.25  ? 230 LEU R CD2 1 
ATOM 1591 N N   . PRO A 1 231 ? 180.231 169.598 156.734 1.00 89.58  ? 231 PRO R N   1 
ATOM 1592 C CA  . PRO A 1 231 ? 180.891 170.305 155.628 1.00 89.58  ? 231 PRO R CA  1 
ATOM 1593 C C   . PRO A 1 231 ? 180.330 169.947 154.266 1.00 89.58  ? 231 PRO R C   1 
ATOM 1594 O O   . PRO A 1 231 ? 180.296 170.805 153.376 1.00 89.58  ? 231 PRO R O   1 
ATOM 1595 C CB  . PRO A 1 231 ? 182.353 169.868 155.764 1.00 89.58  ? 231 PRO R CB  1 
ATOM 1596 C CG  . PRO A 1 231 ? 182.503 169.482 157.155 1.00 89.58  ? 231 PRO R CG  1 
ATOM 1597 C CD  . PRO A 1 231 ? 181.216 168.845 157.531 1.00 89.58  ? 231 PRO R CD  1 
ATOM 1598 N N   . CYS A 1 232 ? 179.888 168.702 154.073 1.00 97.46  ? 232 CYS R N   1 
ATOM 1599 C CA  . CYS A 1 232 ? 179.269 168.332 152.805 1.00 97.46  ? 232 CYS R CA  1 
ATOM 1600 C C   . CYS A 1 232 ? 177.975 169.102 152.581 1.00 97.46  ? 232 CYS R C   1 
ATOM 1601 O O   . CYS A 1 232 ? 177.709 169.567 151.468 1.00 97.46  ? 232 CYS R O   1 
ATOM 1602 C CB  . CYS A 1 232 ? 179.013 166.826 152.764 1.00 97.46  ? 232 CYS R CB  1 
ATOM 1603 S SG  . CYS A 1 232 ? 180.507 165.819 152.609 1.00 97.46  ? 232 CYS R SG  1 
ATOM 1604 N N   . VAL A 1 233 ? 177.159 169.252 153.627 1.00 98.60  ? 233 VAL R N   1 
ATOM 1605 C CA  . VAL A 1 233 ? 175.932 170.035 153.506 1.00 98.60  ? 233 VAL R CA  1 
ATOM 1606 C C   . VAL A 1 233 ? 176.258 171.493 153.214 1.00 98.60  ? 233 VAL R C   1 
ATOM 1607 O O   . VAL A 1 233 ? 175.616 172.133 152.369 1.00 98.60  ? 233 VAL R O   1 
ATOM 1608 C CB  . VAL A 1 233 ? 175.074 169.889 154.776 1.00 98.60  ? 233 VAL R CB  1 
ATOM 1609 C CG1 . VAL A 1 233 ? 173.941 170.895 154.767 1.00 98.60  ? 233 VAL R CG1 1 
ATOM 1610 C CG2 . VAL A 1 233 ? 174.521 168.479 154.876 1.00 98.60  ? 233 VAL R CG2 1 
ATOM 1611 N N   . ALA A 1 234 ? 177.259 172.041 153.905 1.00 94.87  ? 234 ALA R N   1 
ATOM 1612 C CA  . ALA A 1 234 ? 177.645 173.428 153.667 1.00 94.87  ? 234 ALA R CA  1 
ATOM 1613 C C   . ALA A 1 234 ? 178.106 173.635 152.230 1.00 94.87  ? 234 ALA R C   1 
ATOM 1614 O O   . ALA A 1 234 ? 177.747 174.632 151.594 1.00 94.87  ? 234 ALA R O   1 
ATOM 1615 C CB  . ALA A 1 234 ? 178.739 173.845 154.648 1.00 94.87  ? 234 ALA R CB  1 
ATOM 1616 N N   . LEU A 1 235 ? 178.909 172.706 151.703 1.00 97.26  ? 235 LEU R N   1 
ATOM 1617 C CA  . LEU A 1 235 ? 179.342 172.804 150.313 1.00 97.26  ? 235 LEU R CA  1 
ATOM 1618 C C   . LEU A 1 235 ? 178.164 172.676 149.359 1.00 97.26  ? 235 LEU R C   1 
ATOM 1619 O O   . LEU A 1 235 ? 178.048 173.443 148.400 1.00 97.26  ? 235 LEU R O   1 
ATOM 1620 C CB  . LEU A 1 235 ? 180.393 171.737 150.009 1.00 97.26  ? 235 LEU R CB  1 
ATOM 1621 C CG  . LEU A 1 235 ? 180.970 171.732 148.592 1.00 97.26  ? 235 LEU R CG  1 
ATOM 1622 C CD1 . LEU A 1 235 ? 181.411 173.125 148.185 1.00 97.26  ? 235 LEU R CD1 1 
ATOM 1623 C CD2 . LEU A 1 235 ? 182.124 170.752 148.484 1.00 97.26  ? 235 LEU R CD2 1 
ATOM 1624 N N   . LEU A 1 236 ? 177.267 171.721 149.614 1.00 97.20  ? 236 LEU R N   1 
ATOM 1625 C CA  . LEU A 1 236 ? 176.113 171.539 148.744 1.00 97.20  ? 236 LEU R CA  1 
ATOM 1626 C C   . LEU A 1 236 ? 175.235 172.781 148.720 1.00 97.20  ? 236 LEU R C   1 
ATOM 1627 O O   . LEU A 1 236 ? 174.603 173.075 147.699 1.00 97.20  ? 236 LEU R O   1 
ATOM 1628 C CB  . LEU A 1 236 ? 175.312 170.316 149.195 1.00 97.20  ? 236 LEU R CB  1 
ATOM 1629 C CG  . LEU A 1 236 ? 174.242 169.748 148.262 1.00 97.20  ? 236 LEU R CG  1 
ATOM 1630 C CD1 . LEU A 1 236 ? 174.134 168.246 148.451 1.00 97.20  ? 236 LEU R CD1 1 
ATOM 1631 C CD2 . LEU A 1 236 ? 172.891 170.403 148.503 1.00 97.20  ? 236 LEU R CD2 1 
ATOM 1632 N N   . CYS A 1 237 ? 175.185 173.522 149.825 1.00 102.44 ? 237 CYS R N   1 
ATOM 1633 C CA  . CYS A 1 237 ? 174.337 174.703 149.893 1.00 102.44 ? 237 CYS R CA  1 
ATOM 1634 C C   . CYS A 1 237 ? 175.020 175.976 149.410 1.00 102.44 ? 237 CYS R C   1 
ATOM 1635 O O   . CYS A 1 237 ? 174.330 176.882 148.933 1.00 102.44 ? 237 CYS R O   1 
ATOM 1636 C CB  . CYS A 1 237 ? 173.839 174.909 151.325 1.00 102.44 ? 237 CYS R CB  1 
ATOM 1637 S SG  . CYS A 1 237 ? 172.552 173.753 151.820 1.00 102.44 ? 237 CYS R SG  1 
ATOM 1638 N N   . TYR A 1 238 ? 176.348 176.072 149.507 1.00 96.80  ? 238 TYR R N   1 
ATOM 1639 C CA  . TYR A 1 238 ? 177.056 177.292 149.130 1.00 96.80  ? 238 TYR R CA  1 
ATOM 1640 C C   . TYR A 1 238 ? 178.040 177.076 147.983 1.00 96.80  ? 238 TYR R C   1 
ATOM 1641 O O   . TYR A 1 238 ? 178.974 177.866 147.821 1.00 96.80  ? 238 TYR R O   1 
ATOM 1642 C CB  . TYR A 1 238 ? 177.792 177.883 150.334 1.00 96.80  ? 238 TYR R CB  1 
ATOM 1643 C CG  . TYR A 1 238 ? 176.909 178.590 151.336 1.00 96.80  ? 238 TYR R CG  1 
ATOM 1644 C CD1 . TYR A 1 238 ? 175.552 178.757 151.103 1.00 96.80  ? 238 TYR R CD1 1 
ATOM 1645 C CD2 . TYR A 1 238 ? 177.440 179.105 152.510 1.00 96.80  ? 238 TYR R CD2 1 
ATOM 1646 C CE1 . TYR A 1 238 ? 174.745 179.403 152.018 1.00 96.80  ? 238 TYR R CE1 1 
ATOM 1647 C CE2 . TYR A 1 238 ? 176.644 179.755 153.428 1.00 96.80  ? 238 TYR R CE2 1 
ATOM 1648 C CZ  . TYR A 1 238 ? 175.297 179.904 153.177 1.00 96.80  ? 238 TYR R CZ  1 
ATOM 1649 O OH  . TYR A 1 238 ? 174.499 180.552 154.092 1.00 96.80  ? 238 TYR R OH  1 
ATOM 1650 N N   . GLY A 1 239 ? 177.863 176.028 147.186 1.00 99.63  ? 239 GLY R N   1 
ATOM 1651 C CA  . GLY A 1 239 ? 178.743 175.789 146.069 1.00 99.63  ? 239 GLY R CA  1 
ATOM 1652 C C   . GLY A 1 239 ? 178.259 176.323 144.737 1.00 99.63  ? 239 GLY R C   1 
ATOM 1653 O O   . GLY A 1 239 ? 179.001 177.009 144.031 1.00 99.63  ? 239 GLY R O   1 
ATOM 1654 N N   . PRO A 1 240 ? 177.022 175.995 144.344 1.00 102.43 ? 240 PRO R N   1 
ATOM 1655 C CA  . PRO A 1 240 ? 176.527 176.497 143.049 1.00 102.43 ? 240 PRO R CA  1 
ATOM 1656 C C   . PRO A 1 240 ? 176.548 178.012 142.921 1.00 102.43 ? 240 PRO R C   1 
ATOM 1657 O O   . PRO A 1 240 ? 176.915 178.530 141.857 1.00 102.43 ? 240 PRO R O   1 
ATOM 1658 C CB  . PRO A 1 240 ? 175.093 175.948 142.972 1.00 102.43 ? 240 PRO R CB  1 
ATOM 1659 C CG  . PRO A 1 240 ? 174.898 175.064 144.160 1.00 102.43 ? 240 PRO R CG  1 
ATOM 1660 C CD  . PRO A 1 240 ? 176.178 174.919 144.893 1.00 102.43 ? 240 PRO R CD  1 
ATOM 1661 N N   . TYR A 1 241 ? 176.173 178.741 143.974 1.00 101.75 ? 241 TYR R N   1 
ATOM 1662 C CA  . TYR A 1 241 ? 176.096 180.196 143.874 1.00 101.75 ? 241 TYR R CA  1 
ATOM 1663 C C   . TYR A 1 241 ? 177.461 180.799 143.585 1.00 101.75 ? 241 TYR R C   1 
ATOM 1664 O O   . TYR A 1 241 ? 177.628 181.574 142.632 1.00 101.75 ? 241 TYR R O   1 
ATOM 1665 C CB  . TYR A 1 241 ? 175.511 180.778 145.161 1.00 101.75 ? 241 TYR R CB  1 
ATOM 1666 C CG  . TYR A 1 241 ? 175.568 182.286 145.217 1.00 101.75 ? 241 TYR R CG  1 
ATOM 1667 C CD1 . TYR A 1 241 ? 174.809 183.062 144.354 1.00 101.75 ? 241 TYR R CD1 1 
ATOM 1668 C CD2 . TYR A 1 241 ? 176.398 182.934 146.122 1.00 101.75 ? 241 TYR R CD2 1 
ATOM 1669 C CE1 . TYR A 1 241 ? 174.865 184.441 144.399 1.00 101.75 ? 241 TYR R CE1 1 
ATOM 1670 C CE2 . TYR A 1 241 ? 176.461 184.312 146.173 1.00 101.75 ? 241 TYR R CE2 1 
ATOM 1671 C CZ  . TYR A 1 241 ? 175.692 185.060 145.309 1.00 101.75 ? 241 TYR R CZ  1 
ATOM 1672 O OH  . TYR A 1 241 ? 175.751 186.433 145.356 1.00 101.75 ? 241 TYR R OH  1 
ATOM 1673 N N   . HIS A 1 242 ? 178.459 180.432 144.382 1.00 100.50 ? 242 HIS R N   1 
ATOM 1674 C CA  . HIS A 1 242 ? 179.792 180.968 144.181 1.00 100.50 ? 242 HIS R CA  1 
ATOM 1675 C C   . HIS A 1 242 ? 180.455 180.405 142.937 1.00 100.50 ? 242 HIS R C   1 
ATOM 1676 O O   . HIS A 1 242 ? 181.275 181.096 142.332 1.00 100.50 ? 242 HIS R O   1 
ATOM 1677 C CB  . HIS A 1 242 ? 180.649 180.709 145.418 1.00 100.50 ? 242 HIS R CB  1 
ATOM 1678 C CG  . HIS A 1 242 ? 180.098 181.329 146.663 1.00 100.50 ? 242 HIS R CG  1 
ATOM 1679 N ND1 . HIS A 1 242 ? 180.508 182.559 147.125 1.00 100.50 ? 242 HIS R ND1 1 
ATOM 1680 C CD2 . HIS A 1 242 ? 179.150 180.899 147.528 1.00 100.50 ? 242 HIS R CD2 1 
ATOM 1681 C CE1 . HIS A 1 242 ? 179.846 182.855 148.229 1.00 100.50 ? 242 HIS R CE1 1 
ATOM 1682 N NE2 . HIS A 1 242 ? 179.016 181.864 148.495 1.00 100.50 ? 242 HIS R NE2 1 
ATOM 1683 N N   . ALA A 1 243 ? 180.086 179.195 142.513 1.00 117.01 ? 243 ALA R N   1 
ATOM 1684 C CA  . ALA A 1 243 ? 180.588 178.675 141.246 1.00 117.01 ? 243 ALA R CA  1 
ATOM 1685 C C   . ALA A 1 243 ? 180.115 179.534 140.081 1.00 117.01 ? 243 ALA R C   1 
ATOM 1686 O O   . ALA A 1 243 ? 180.917 179.950 139.235 1.00 117.01 ? 243 ALA R O   1 
ATOM 1687 C CB  . ALA A 1 243 ? 180.146 177.225 141.061 1.00 117.01 ? 243 ALA R CB  1 
ATOM 1688 N N   . LEU A 1 244 ? 178.811 179.821 140.028 1.00 118.18 ? 244 LEU R N   1 
ATOM 1689 C CA  . LEU A 1 244 ? 178.283 180.662 138.958 1.00 118.18 ? 244 LEU R CA  1 
ATOM 1690 C C   . LEU A 1 244 ? 178.870 182.066 139.017 1.00 118.18 ? 244 LEU R C   1 
ATOM 1691 O O   . LEU A 1 244 ? 179.248 182.632 137.982 1.00 118.18 ? 244 LEU R O   1 
ATOM 1692 C CB  . LEU A 1 244 ? 176.758 180.715 139.027 1.00 118.18 ? 244 LEU R CB  1 
ATOM 1693 C CG  . LEU A 1 244 ? 175.960 179.638 138.286 1.00 118.18 ? 244 LEU R CG  1 
ATOM 1694 C CD1 . LEU A 1 244 ? 176.241 179.710 136.795 1.00 118.18 ? 244 LEU R CD1 1 
ATOM 1695 C CD2 . LEU A 1 244 ? 176.236 178.244 138.813 1.00 118.18 ? 244 LEU R CD2 1 
ATOM 1696 N N   . LEU A 1 245 ? 178.968 182.641 140.219 1.00 118.16 ? 245 LEU R N   1 
ATOM 1697 C CA  . LEU A 1 245 ? 179.520 183.987 140.350 1.00 118.16 ? 245 LEU R CA  1 
ATOM 1698 C C   . LEU A 1 245 ? 180.979 184.038 139.903 1.00 118.16 ? 245 LEU R C   1 
ATOM 1699 O O   . LEU A 1 245 ? 181.387 184.952 139.173 1.00 118.16 ? 245 LEU R O   1 
ATOM 1700 C CB  . LEU A 1 245 ? 179.379 184.467 141.794 1.00 118.16 ? 245 LEU R CB  1 
ATOM 1701 C CG  . LEU A 1 245 ? 179.205 185.972 142.002 1.00 118.16 ? 245 LEU R CG  1 
ATOM 1702 C CD1 . LEU A 1 245 ? 177.921 186.467 141.357 1.00 118.16 ? 245 LEU R CD1 1 
ATOM 1703 C CD2 . LEU A 1 245 ? 179.229 186.315 143.484 1.00 118.16 ? 245 LEU R CD2 1 
ATOM 1704 N N   . LEU A 1 246 ? 181.782 183.061 140.333 1.00 122.55 ? 246 LEU R N   1 
ATOM 1705 C CA  . LEU A 1 246 ? 183.189 183.027 139.960 1.00 122.55 ? 246 LEU R CA  1 
ATOM 1706 C C   . LEU A 1 246 ? 183.354 182.819 138.465 1.00 122.55 ? 246 LEU R C   1 
ATOM 1707 O O   . LEU A 1 246 ? 184.210 183.451 137.841 1.00 122.55 ? 246 LEU R O   1 
ATOM 1708 C CB  . LEU A 1 246 ? 183.907 181.926 140.738 1.00 122.55 ? 246 LEU R CB  1 
ATOM 1709 C CG  . LEU A 1 246 ? 185.433 181.892 140.645 1.00 122.55 ? 246 LEU R CG  1 
ATOM 1710 C CD1 . LEU A 1 246 ? 186.043 183.098 141.334 1.00 122.55 ? 246 LEU R CD1 1 
ATOM 1711 C CD2 . LEU A 1 246 ? 185.978 180.603 141.237 1.00 122.55 ? 246 LEU R CD2 1 
ATOM 1712 N N   . LEU A 1 247 ? 182.539 181.947 137.870 1.00 125.55 ? 247 LEU R N   1 
ATOM 1713 C CA  . LEU A 1 247 ? 182.606 181.739 136.429 1.00 125.55 ? 247 LEU R CA  1 
ATOM 1714 C C   . LEU A 1 247 ? 182.296 183.027 135.681 1.00 125.55 ? 247 LEU R C   1 
ATOM 1715 O O   . LEU A 1 247 ? 183.044 183.436 134.783 1.00 125.55 ? 247 LEU R O   1 
ATOM 1716 C CB  . LEU A 1 247 ? 181.638 180.625 136.025 1.00 125.55 ? 247 LEU R CB  1 
ATOM 1717 C CG  . LEU A 1 247 ? 181.498 180.278 134.544 1.00 125.55 ? 247 LEU R CG  1 
ATOM 1718 C CD1 . LEU A 1 247 ? 182.814 179.765 133.982 1.00 125.55 ? 247 LEU R CD1 1 
ATOM 1719 C CD2 . LEU A 1 247 ? 180.393 179.252 134.355 1.00 125.55 ? 247 LEU R CD2 1 
ATOM 1720 N N   . ARG A 1 248 ? 181.203 183.694 136.062 1.00 122.50 ? 248 ARG R N   1 
ATOM 1721 C CA  . ARG A 1 248 ? 180.822 184.941 135.409 1.00 122.50 ? 248 ARG R CA  1 
ATOM 1722 C C   . ARG A 1 248 ? 181.936 185.971 135.503 1.00 122.50 ? 248 ARG R C   1 
ATOM 1723 O O   . ARG A 1 248 ? 182.360 186.539 134.489 1.00 122.50 ? 248 ARG R O   1 
ATOM 1724 C CB  . ARG A 1 248 ? 179.542 185.487 136.036 1.00 30.00  ? 248 ARG R CB  1 
ATOM 1725 C CG  . ARG A 1 248 ? 178.982 186.714 135.340 1.00 30.00  ? 248 ARG R CG  1 
ATOM 1726 C CD  . ARG A 1 248 ? 177.755 187.235 136.067 1.00 30.00  ? 248 ARG R CD  1 
ATOM 1727 N NE  . ARG A 1 248 ? 176.691 186.237 136.133 1.00 30.00  ? 248 ARG R NE  1 
ATOM 1728 C CZ  . ARG A 1 248 ? 175.612 186.351 136.898 1.00 30.00  ? 248 ARG R CZ  1 
ATOM 1729 N NH1 . ARG A 1 248 ? 175.452 187.418 137.666 1.00 30.00  ? 248 ARG R NH1 1 
ATOM 1730 N NH2 . ARG A 1 248 ? 174.694 185.396 136.897 1.00 30.00  ? 248 ARG R NH2 1 
ATOM 1731 N N   . SER A 1 249 ? 182.432 186.220 136.718 1.00 115.92 ? 249 SER R N   1 
ATOM 1732 C CA  . SER A 1 249 ? 183.432 187.266 136.892 1.00 115.92 ? 249 SER R CA  1 
ATOM 1733 C C   . SER A 1 249 ? 184.738 186.914 136.190 1.00 115.92 ? 249 SER R C   1 
ATOM 1734 O O   . SER A 1 249 ? 185.352 187.776 135.549 1.00 115.92 ? 249 SER R O   1 
ATOM 1735 C CB  . SER A 1 249 ? 183.671 187.522 138.378 1.00 115.92 ? 249 SER R CB  1 
ATOM 1736 O OG  . SER A 1 249 ? 184.530 188.633 138.566 1.00 115.92 ? 249 SER R OG  1 
ATOM 1737 N N   . LEU A 1 250 ? 185.180 185.658 136.298 1.00 118.48 ? 250 LEU R N   1 
ATOM 1738 C CA  . LEU A 1 250 ? 186.442 185.259 135.691 1.00 118.48 ? 250 LEU R CA  1 
ATOM 1739 C C   . LEU A 1 250 ? 186.388 185.374 134.176 1.00 118.48 ? 250 LEU R C   1 
ATOM 1740 O O   . LEU A 1 250 ? 187.347 185.842 133.550 1.00 118.48 ? 250 LEU R O   1 
ATOM 1741 C CB  . LEU A 1 250 ? 186.798 183.835 136.111 1.00 118.48 ? 250 LEU R CB  1 
ATOM 1742 N N   . VAL A 1 251 ? 185.280 184.951 133.561 1.00 122.24 ? 251 VAL R N   1 
ATOM 1743 C CA  . VAL A 1 251 ? 185.154 185.111 132.116 1.00 122.24 ? 251 VAL R CA  1 
ATOM 1744 C C   . VAL A 1 251 ? 185.114 186.588 131.751 1.00 122.24 ? 251 VAL R C   1 
ATOM 1745 O O   . VAL A 1 251 ? 185.802 187.033 130.824 1.00 122.24 ? 251 VAL R O   1 
ATOM 1746 C CB  . VAL A 1 251 ? 183.917 184.365 131.589 1.00 122.24 ? 251 VAL R CB  1 
ATOM 1747 C CG1 . VAL A 1 251 ? 183.727 184.661 130.113 1.00 122.24 ? 251 VAL R CG1 1 
ATOM 1748 C CG2 . VAL A 1 251 ? 184.065 182.870 131.817 1.00 122.24 ? 251 VAL R CG2 1 
ATOM 1749 N N   . PHE A 1 252 ? 184.313 187.374 132.480 1.00 121.85 ? 252 PHE R N   1 
ATOM 1750 C CA  . PHE A 1 252 ? 184.161 188.786 132.143 1.00 121.85 ? 252 PHE R CA  1 
ATOM 1751 C C   . PHE A 1 252 ? 185.479 189.538 132.248 1.00 121.85 ? 252 PHE R C   1 
ATOM 1752 O O   . PHE A 1 252 ? 185.705 190.498 131.501 1.00 121.85 ? 252 PHE R O   1 
ATOM 1753 C CB  . PHE A 1 252 ? 183.109 189.434 133.040 1.00 121.85 ? 252 PHE R CB  1 
ATOM 1754 C CG  . PHE A 1 252 ? 182.503 190.674 132.456 1.00 121.85 ? 252 PHE R CG  1 
ATOM 1755 C CD1 . PHE A 1 252 ? 181.320 190.608 131.740 1.00 121.85 ? 252 PHE R CD1 1 
ATOM 1756 C CD2 . PHE A 1 252 ? 183.118 191.904 132.613 1.00 121.85 ? 252 PHE R CD2 1 
ATOM 1757 C CE1 . PHE A 1 252 ? 180.760 191.744 131.194 1.00 121.85 ? 252 PHE R CE1 1 
ATOM 1758 C CE2 . PHE A 1 252 ? 182.562 193.045 132.069 1.00 121.85 ? 252 PHE R CE2 1 
ATOM 1759 C CZ  . PHE A 1 252 ? 181.382 192.964 131.358 1.00 121.85 ? 252 PHE R CZ  1 
ATOM 1760 N N   . LEU A 1 253 ? 186.358 189.129 133.167 1.00 119.40 ? 253 LEU R N   1 
ATOM 1761 C CA  . LEU A 1 253 ? 187.706 189.685 133.174 1.00 119.40 ? 253 LEU R CA  1 
ATOM 1762 C C   . LEU A 1 253 ? 188.434 189.341 131.883 1.00 119.40 ? 253 LEU R C   1 
ATOM 1763 O O   . LEU A 1 253 ? 189.127 190.187 131.307 1.00 119.40 ? 253 LEU R O   1 
ATOM 1764 C CB  . LEU A 1 253 ? 188.486 189.175 134.390 1.00 119.40 ? 253 LEU R CB  1 
ATOM 1765 C CG  . LEU A 1 253 ? 189.853 189.801 134.721 1.00 119.40 ? 253 LEU R CG  1 
ATOM 1766 C CD1 . LEU A 1 253 ? 190.152 189.668 136.205 1.00 119.40 ? 253 LEU R CD1 1 
ATOM 1767 C CD2 . LEU A 1 253 ? 190.992 189.192 133.914 1.00 119.40 ? 253 LEU R CD2 1 
ATOM 1768 N N   . VAL A 1 254 ? 188.284 188.105 131.410 1.00 124.76 ? 254 VAL R N   1 
ATOM 1769 C CA  . VAL A 1 254 ? 188.989 187.641 130.220 1.00 124.76 ? 254 VAL R CA  1 
ATOM 1770 C C   . VAL A 1 254 ? 188.380 188.249 128.962 1.00 124.76 ? 254 VAL R C   1 
ATOM 1771 O O   . VAL A 1 254 ? 189.096 188.757 128.099 1.00 124.76 ? 254 VAL R O   1 
ATOM 1772 C CB  . VAL A 1 254 ? 188.985 186.100 130.134 1.00 124.76 ? 254 VAL R CB  1 
ATOM 1773 C CG1 . VAL A 1 254 ? 189.563 185.638 128.805 1.00 124.76 ? 254 VAL R CG1 1 
ATOM 1774 C CG2 . VAL A 1 254 ? 189.767 185.501 131.290 1.00 124.76 ? 254 VAL R CG2 1 
ATOM 1775 N N   . GLY A 1 263 ? 181.241 184.445 123.920 1.00 112.57 ? 263 GLY R N   1 
ATOM 1776 C CA  . GLY A 1 263 ? 180.526 185.707 123.884 1.00 112.57 ? 263 GLY R CA  1 
ATOM 1777 C C   . GLY A 1 263 ? 179.920 186.082 125.222 1.00 112.57 ? 263 GLY R C   1 
ATOM 1778 O O   . GLY A 1 263 ? 179.162 185.308 125.806 1.00 112.57 ? 263 GLY R O   1 
ATOM 1779 N N   . GLY A 1 264 ? 180.257 187.278 125.710 1.00 113.22 ? 264 GLY R N   1 
ATOM 1780 C CA  . GLY A 1 264 ? 179.756 187.704 127.006 1.00 113.22 ? 264 GLY R CA  1 
ATOM 1781 C C   . GLY A 1 264 ? 178.246 187.844 127.038 1.00 113.22 ? 264 GLY R C   1 
ATOM 1782 O O   . GLY A 1 264 ? 177.596 187.425 128.000 1.00 113.22 ? 264 GLY R O   1 
ATOM 1783 N N   . CYS A 1 265 ? 177.671 188.442 125.993 1.00 108.77 ? 265 CYS R N   1 
ATOM 1784 C CA  . CYS A 1 265 ? 176.224 188.606 125.917 1.00 108.77 ? 265 CYS R CA  1 
ATOM 1785 C C   . CYS A 1 265 ? 175.511 187.263 126.019 1.00 108.77 ? 265 CYS R C   1 
ATOM 1786 O O   . CYS A 1 265 ? 174.635 187.064 126.870 1.00 108.77 ? 265 CYS R O   1 
ATOM 1787 C CB  . CYS A 1 265 ? 175.855 189.317 124.615 1.00 108.77 ? 265 CYS R CB  1 
ATOM 1788 S SG  . CYS A 1 265 ? 174.127 189.834 124.508 1.00 108.77 ? 265 CYS R SG  1 
ATOM 1789 N N   . ALA A 1 266 ? 175.896 186.317 125.161 1.00 112.26 ? 266 ALA R N   1 
ATOM 1790 C CA  . ALA A 1 266 ? 175.252 185.010 125.159 1.00 112.26 ? 266 ALA R CA  1 
ATOM 1791 C C   . ALA A 1 266 ? 175.534 184.241 126.443 1.00 112.26 ? 266 ALA R C   1 
ATOM 1792 O O   . ALA A 1 266 ? 174.677 183.479 126.908 1.00 112.26 ? 266 ALA R O   1 
ATOM 1793 C CB  . ALA A 1 266 ? 175.708 184.209 123.940 1.00 112.26 ? 266 ALA R CB  1 
ATOM 1794 N N   . LEU A 1 267 ? 176.720 184.419 127.026 1.00 116.99 ? 267 LEU R N   1 
ATOM 1795 C CA  . LEU A 1 267 ? 177.015 183.759 128.292 1.00 116.99 ? 267 LEU R CA  1 
ATOM 1796 C C   . LEU A 1 267 ? 176.094 184.260 129.396 1.00 116.99 ? 267 LEU R C   1 
ATOM 1797 O O   . LEU A 1 267 ? 175.581 183.466 130.194 1.00 116.99 ? 267 LEU R O   1 
ATOM 1798 C CB  . LEU A 1 267 ? 178.478 183.971 128.676 1.00 116.99 ? 267 LEU R CB  1 
ATOM 1799 C CG  . LEU A 1 267 ? 178.918 183.294 129.976 1.00 116.99 ? 267 LEU R CG  1 
ATOM 1800 C CD1 . LEU A 1 267 ? 178.456 181.844 130.019 1.00 116.99 ? 267 LEU R CD1 1 
ATOM 1801 C CD2 . LEU A 1 267 ? 180.419 183.375 130.132 1.00 116.99 ? 267 LEU R CD2 1 
ATOM 1802 N N   . GLU A 1 268 ? 175.871 185.575 129.460 1.00 113.81 ? 268 GLU R N   1 
ATOM 1803 C CA  . GLU A 1 268 ? 174.918 186.108 130.428 1.00 113.81 ? 268 GLU R CA  1 
ATOM 1804 C C   . GLU A 1 268 ? 173.511 185.602 130.145 1.00 113.81 ? 268 GLU R C   1 
ATOM 1805 O O   . GLU A 1 268 ? 172.752 185.305 131.075 1.00 113.81 ? 268 GLU R O   1 
ATOM 1806 C CB  . GLU A 1 268 ? 174.950 187.636 130.423 1.00 113.81 ? 268 GLU R CB  1 
ATOM 1807 C CG  . GLU A 1 268 ? 176.297 188.235 130.790 1.00 113.81 ? 268 GLU R CG  1 
ATOM 1808 C CD  . GLU A 1 268 ? 176.751 187.853 132.187 1.00 113.81 ? 268 GLU R CD  1 
ATOM 1809 O OE1 . GLU A 1 268 ? 175.886 187.656 133.067 1.00 113.81 ? 268 GLU R OE1 1 
ATOM 1810 O OE2 . GLU A 1 268 ? 177.976 187.752 132.406 1.00 113.81 ? 268 GLU R OE2 1 
ATOM 1811 N N   . GLU A 1 269 ? 173.139 185.512 128.866 1.00 114.90 ? 269 GLU R N   1 
ATOM 1812 C CA  . GLU A 1 269 ? 171.822 184.987 128.513 1.00 114.90 ? 269 GLU R CA  1 
ATOM 1813 C C   . GLU A 1 269 ? 171.630 183.570 129.042 1.00 114.90 ? 269 GLU R C   1 
ATOM 1814 O O   . GLU A 1 269 ? 170.595 183.252 129.639 1.00 114.90 ? 269 GLU R O   1 
ATOM 1815 C CB  . GLU A 1 269 ? 171.626 185.015 126.997 1.00 30.00  ? 269 GLU R CB  1 
ATOM 1816 C CG  . GLU A 1 269 ? 171.681 186.389 126.367 1.00 30.00  ? 269 GLU R CG  1 
ATOM 1817 C CD  . GLU A 1 269 ? 171.065 186.407 124.985 1.00 30.00  ? 269 GLU R CD  1 
ATOM 1818 O OE1 . GLU A 1 269 ? 171.564 185.676 124.101 1.00 30.00  ? 269 GLU R OE1 1 
ATOM 1819 O OE2 . GLU A 1 269 ? 170.079 187.147 124.785 1.00 30.00  ? 269 GLU R OE2 1 
ATOM 1820 N N   . ARG A 1 270 ? 172.617 182.699 128.825 1.00 114.60 ? 270 ARG R N   1 
ATOM 1821 C CA  . ARG A 1 270 ? 172.448 181.298 129.197 1.00 114.60 ? 270 ARG R CA  1 
ATOM 1822 C C   . ARG A 1 270 ? 172.598 181.074 130.697 1.00 114.60 ? 270 ARG R C   1 
ATOM 1823 O O   . ARG A 1 270 ? 171.899 180.231 131.269 1.00 114.60 ? 270 ARG R O   1 
ATOM 1824 C CB  . ARG A 1 270 ? 173.437 180.416 128.437 1.00 114.60 ? 270 ARG R CB  1 
ATOM 1825 C CG  . ARG A 1 270 ? 172.986 180.016 127.043 1.00 114.60 ? 270 ARG R CG  1 
ATOM 1826 C CD  . ARG A 1 270 ? 173.981 179.051 126.410 1.00 114.60 ? 270 ARG R CD  1 
ATOM 1827 N NE  . ARG A 1 270 ? 174.036 179.159 124.954 1.00 114.60 ? 270 ARG R NE  1 
ATOM 1828 C CZ  . ARG A 1 270 ? 174.543 180.196 124.295 1.00 114.60 ? 270 ARG R CZ  1 
ATOM 1829 N NH1 . ARG A 1 270 ? 175.047 181.225 124.957 1.00 114.60 ? 270 ARG R NH1 1 
ATOM 1830 N NH2 . ARG A 1 270 ? 174.550 180.200 122.970 1.00 114.60 ? 270 ARG R NH2 1 
ATOM 1831 N N   . LEU A 1 271 ? 173.494 181.808 131.351 1.00 114.58 ? 271 LEU R N   1 
ATOM 1832 C CA  . LEU A 1 271 ? 173.851 181.525 132.734 1.00 114.58 ? 271 LEU R CA  1 
ATOM 1833 C C   . LEU A 1 271 ? 173.032 182.320 133.739 1.00 114.58 ? 271 LEU R C   1 
ATOM 1834 O O   . LEU A 1 271 ? 173.322 182.262 134.937 1.00 114.58 ? 271 LEU R O   1 
ATOM 1835 C CB  . LEU A 1 271 ? 175.342 181.794 132.957 1.00 114.58 ? 271 LEU R CB  1 
ATOM 1836 N N   . PHE A 1 272 ? 172.030 183.061 133.290 1.00 113.59 ? 272 PHE R N   1 
ATOM 1837 C CA  . PHE A 1 272 ? 171.194 183.816 134.214 1.00 113.59 ? 272 PHE R CA  1 
ATOM 1838 C C   . PHE A 1 272 ? 170.189 182.937 134.961 1.00 113.59 ? 272 PHE R C   1 
ATOM 1839 O O   . PHE A 1 272 ? 170.174 182.958 136.199 1.00 113.59 ? 272 PHE R O   1 
ATOM 1840 C CB  . PHE A 1 272 ? 170.453 184.938 133.483 1.00 113.59 ? 272 PHE R CB  1 
ATOM 1841 C CG  . PHE A 1 272 ? 169.263 185.464 134.238 1.00 113.59 ? 272 PHE R CG  1 
ATOM 1842 C CD1 . PHE A 1 272 ? 169.429 186.383 135.259 1.00 113.59 ? 272 PHE R CD1 1 
ATOM 1843 C CD2 . PHE A 1 272 ? 167.981 185.046 133.924 1.00 113.59 ? 272 PHE R CD2 1 
ATOM 1844 C CE1 . PHE A 1 272 ? 168.343 186.867 135.956 1.00 113.59 ? 272 PHE R CE1 1 
ATOM 1845 C CE2 . PHE A 1 272 ? 166.892 185.526 134.618 1.00 113.59 ? 272 PHE R CE2 1 
ATOM 1846 C CZ  . PHE A 1 272 ? 167.073 186.440 135.634 1.00 113.59 ? 272 PHE R CZ  1 
ATOM 1847 N N   . PRO A 1 273 ? 169.335 182.158 134.278 1.00 118.59 ? 273 PRO R N   1 
ATOM 1848 C CA  . PRO A 1 273 ? 168.195 181.558 134.987 1.00 118.59 ? 273 PRO R CA  1 
ATOM 1849 C C   . PRO A 1 273 ? 168.578 180.459 135.956 1.00 118.59 ? 273 PRO R C   1 
ATOM 1850 O O   . PRO A 1 273 ? 167.760 180.107 136.814 1.00 118.59 ? 273 PRO R O   1 
ATOM 1851 C CB  . PRO A 1 273 ? 167.311 181.024 133.854 1.00 118.59 ? 273 PRO R CB  1 
ATOM 1852 C CG  . PRO A 1 273 ? 168.193 180.900 132.670 1.00 118.59 ? 273 PRO R CG  1 
ATOM 1853 C CD  . PRO A 1 273 ? 169.522 181.530 132.958 1.00 118.59 ? 273 PRO R CD  1 
ATOM 1854 N N   . ALA A 1 274 ? 169.783 179.908 135.861 1.00 117.67 ? 274 ALA R N   1 
ATOM 1855 C CA  . ALA A 1 274 ? 170.237 178.946 136.855 1.00 117.67 ? 274 ALA R CA  1 
ATOM 1856 C C   . ALA A 1 274 ? 170.935 179.615 138.029 1.00 117.67 ? 274 ALA R C   1 
ATOM 1857 O O   . ALA A 1 274 ? 170.813 179.144 139.167 1.00 117.67 ? 274 ALA R O   1 
ATOM 1858 C CB  . ALA A 1 274 ? 171.178 177.923 136.214 1.00 117.67 ? 274 ALA R CB  1 
ATOM 1859 N N   . TYR A 1 275 ? 171.663 180.706 137.775 1.00 115.41 ? 275 TYR R N   1 
ATOM 1860 C CA  . TYR A 1 275 ? 172.279 181.462 138.860 1.00 115.41 ? 275 TYR R CA  1 
ATOM 1861 C C   . TYR A 1 275 ? 171.227 182.031 139.798 1.00 115.41 ? 275 TYR R C   1 
ATOM 1862 O O   . TYR A 1 275 ? 171.411 182.039 141.021 1.00 115.41 ? 275 TYR R O   1 
ATOM 1863 C CB  . TYR A 1 275 ? 173.148 182.582 138.290 1.00 115.41 ? 275 TYR R CB  1 
ATOM 1864 C CG  . TYR A 1 275 ? 173.547 183.636 139.298 1.00 115.41 ? 275 TYR R CG  1 
ATOM 1865 C CD1 . TYR A 1 275 ? 172.780 184.781 139.481 1.00 115.41 ? 275 TYR R CD1 1 
ATOM 1866 C CD2 . TYR A 1 275 ? 174.693 183.488 140.067 1.00 115.41 ? 275 TYR R CD2 1 
ATOM 1867 C CE1 . TYR A 1 275 ? 173.143 185.746 140.401 1.00 115.41 ? 275 TYR R CE1 1 
ATOM 1868 C CE2 . TYR A 1 275 ? 175.064 184.448 140.988 1.00 115.41 ? 275 TYR R CE2 1 
ATOM 1869 C CZ  . TYR A 1 275 ? 174.286 185.575 141.151 1.00 115.41 ? 275 TYR R CZ  1 
ATOM 1870 O OH  . TYR A 1 275 ? 174.650 186.534 142.068 1.00 115.41 ? 275 TYR R OH  1 
ATOM 1871 N N   . HIS A 1 276 ? 170.120 182.521 139.242 1.00 117.00 ? 276 HIS R N   1 
ATOM 1872 C CA  . HIS A 1 276 ? 169.084 183.131 140.060 1.00 117.00 ? 276 HIS R CA  1 
ATOM 1873 C C   . HIS A 1 276 ? 168.327 182.091 140.874 1.00 117.00 ? 276 HIS R C   1 
ATOM 1874 O O   . HIS A 1 276 ? 167.673 182.446 141.859 1.00 117.00 ? 276 HIS R O   1 
ATOM 1875 C CB  . HIS A 1 276 ? 168.126 183.915 139.163 1.00 117.00 ? 276 HIS R CB  1 
ATOM 1876 C CG  . HIS A 1 276 ? 167.251 184.880 139.899 1.00 117.00 ? 276 HIS R CG  1 
ATOM 1877 N ND1 . HIS A 1 276 ? 166.142 185.462 139.324 1.00 117.00 ? 276 HIS R ND1 1 
ATOM 1878 C CD2 . HIS A 1 276 ? 167.348 185.405 141.143 1.00 117.00 ? 276 HIS R CD2 1 
ATOM 1879 C CE1 . HIS A 1 276 ? 165.578 186.283 140.191 1.00 117.00 ? 276 HIS R CE1 1 
ATOM 1880 N NE2 . HIS A 1 276 ? 166.292 186.269 141.301 1.00 117.00 ? 276 HIS R NE2 1 
ATOM 1881 N N   . ALA A 1 277 ? 168.407 180.817 140.485 1.00 113.90 ? 277 ALA R N   1 
ATOM 1882 C CA  . ALA A 1 277 ? 167.816 179.723 141.240 1.00 113.90 ? 277 ALA R CA  1 
ATOM 1883 C C   . ALA A 1 277 ? 168.824 179.003 142.120 1.00 113.90 ? 277 ALA R C   1 
ATOM 1884 O O   . ALA A 1 277 ? 168.430 178.136 142.907 1.00 113.90 ? 277 ALA R O   1 
ATOM 1885 C CB  . ALA A 1 277 ? 167.158 178.713 140.293 1.00 113.90 ? 277 ALA R CB  1 
ATOM 1886 N N   . SER A 1 278 ? 170.110 179.326 141.995 1.00 115.71 ? 278 SER R N   1 
ATOM 1887 C CA  . SER A 1 278 ? 171.093 178.807 142.936 1.00 115.71 ? 278 SER R CA  1 
ATOM 1888 C C   . SER A 1 278 ? 170.966 179.473 144.303 1.00 115.71 ? 278 SER R C   1 
ATOM 1889 O O   . SER A 1 278 ? 171.348 178.883 145.321 1.00 115.71 ? 278 SER R O   1 
ATOM 1890 C CB  . SER A 1 278 ? 172.498 178.997 142.381 1.00 115.71 ? 278 SER R CB  1 
ATOM 1891 O OG  . SER A 1 278 ? 173.453 178.772 143.394 1.00 115.71 ? 278 SER R OG  1 
ATOM 1892 N N   . LEU A 1 279 ? 170.447 180.701 144.348 1.00 113.62 ? 279 LEU R N   1 
ATOM 1893 C CA  . LEU A 1 279 ? 170.204 181.348 145.632 1.00 113.62 ? 279 LEU R CA  1 
ATOM 1894 C C   . LEU A 1 279 ? 169.122 180.627 146.423 1.00 113.62 ? 279 LEU R C   1 
ATOM 1895 O O   . LEU A 1 279 ? 169.143 180.647 147.658 1.00 113.62 ? 279 LEU R O   1 
ATOM 1896 C CB  . LEU A 1 279 ? 169.826 182.813 145.423 1.00 113.62 ? 279 LEU R CB  1 
ATOM 1897 C CG  . LEU A 1 279 ? 170.990 183.764 145.154 1.00 113.62 ? 279 LEU R CG  1 
ATOM 1898 C CD1 . LEU A 1 279 ? 170.473 185.137 144.777 1.00 113.62 ? 279 LEU R CD1 1 
ATOM 1899 C CD2 . LEU A 1 279 ? 171.899 183.845 146.368 1.00 113.62 ? 279 LEU R CD2 1 
ATOM 1900 N N   . ALA A 1 280 ? 168.173 179.990 145.735 1.00 112.18 ? 280 ALA R N   1 
ATOM 1901 C CA  . ALA A 1 280 ? 167.209 179.144 146.426 1.00 112.18 ? 280 ALA R CA  1 
ATOM 1902 C C   . ALA A 1 280 ? 167.897 178.003 147.162 1.00 112.18 ? 280 ALA R C   1 
ATOM 1903 O O   . ALA A 1 280 ? 167.456 177.609 148.247 1.00 112.18 ? 280 ALA R O   1 
ATOM 1904 C CB  . ALA A 1 280 ? 166.181 178.598 145.436 1.00 112.18 ? 280 ALA R CB  1 
ATOM 1905 N N   . LEU A 1 281 ? 168.972 177.455 146.588 1.00 107.89 ? 281 LEU R N   1 
ATOM 1906 C CA  . LEU A 1 281 ? 169.747 176.427 147.274 1.00 107.89 ? 281 LEU R CA  1 
ATOM 1907 C C   . LEU A 1 281 ? 170.598 177.023 148.385 1.00 107.89 ? 281 LEU R C   1 
ATOM 1908 O O   . LEU A 1 281 ? 170.792 176.392 149.430 1.00 107.89 ? 281 LEU R O   1 
ATOM 1909 C CB  . LEU A 1 281 ? 170.636 175.676 146.281 1.00 107.89 ? 281 LEU R CB  1 
ATOM 1910 C CG  . LEU A 1 281 ? 170.035 174.485 145.535 1.00 107.89 ? 281 LEU R CG  1 
ATOM 1911 C CD1 . LEU A 1 281 ? 169.045 174.939 144.472 1.00 107.89 ? 281 LEU R CD1 1 
ATOM 1912 C CD2 . LEU A 1 281 ? 171.137 173.636 144.921 1.00 107.89 ? 281 LEU R CD2 1 
ATOM 1913 N N   . ALA A 1 282 ? 171.123 178.228 148.163 1.00 108.53 ? 282 ALA R N   1 
ATOM 1914 C CA  . ALA A 1 282 ? 171.912 178.893 149.196 1.00 108.53 ? 282 ALA R CA  1 
ATOM 1915 C C   . ALA A 1 282 ? 171.075 179.161 150.440 1.00 108.53 ? 282 ALA R C   1 
ATOM 1916 O O   . ALA A 1 282 ? 171.560 179.024 151.568 1.00 108.53 ? 282 ALA R O   1 
ATOM 1917 C CB  . ALA A 1 282 ? 172.503 180.194 148.655 1.00 108.53 ? 282 ALA R CB  1 
ATOM 1918 N N   . THR A 1 283 ? 169.813 179.547 150.252 1.00 107.82 ? 283 THR R N   1 
ATOM 1919 C CA  . THR A 1 283 ? 168.928 179.826 151.375 1.00 107.82 ? 283 THR R CA  1 
ATOM 1920 C C   . THR A 1 283 ? 168.560 178.579 152.165 1.00 107.82 ? 283 THR R C   1 
ATOM 1921 O O   . THR A 1 283 ? 167.992 178.708 153.254 1.00 107.82 ? 283 THR R O   1 
ATOM 1922 C CB  . THR A 1 283 ? 167.650 180.507 150.886 1.00 107.82 ? 283 THR R CB  1 
ATOM 1923 O OG1 . THR A 1 283 ? 167.066 179.734 149.830 1.00 107.82 ? 283 THR R OG1 1 
ATOM 1924 C CG2 . THR A 1 283 ? 167.950 181.910 150.381 1.00 107.82 ? 283 THR R CG2 1 
ATOM 1925 N N   . LEU A 1 284 ? 168.852 177.384 151.652 1.00 108.18 ? 284 LEU R N   1 
ATOM 1926 C CA  . LEU A 1 284 ? 168.567 176.169 152.401 1.00 108.18 ? 284 LEU R CA  1 
ATOM 1927 C C   . LEU A 1 284 ? 169.544 175.947 153.547 1.00 108.18 ? 284 LEU R C   1 
ATOM 1928 O O   . LEU A 1 284 ? 169.253 175.151 154.446 1.00 108.18 ? 284 LEU R O   1 
ATOM 1929 C CB  . LEU A 1 284 ? 168.581 174.957 151.470 1.00 108.18 ? 284 LEU R CB  1 
ATOM 1930 C CG  . LEU A 1 284 ? 167.525 174.944 150.366 1.00 108.18 ? 284 LEU R CG  1 
ATOM 1931 C CD1 . LEU A 1 284 ? 167.785 173.807 149.390 1.00 108.18 ? 284 LEU R CD1 1 
ATOM 1932 C CD2 . LEU A 1 284 ? 166.131 174.835 150.963 1.00 108.18 ? 284 LEU R CD2 1 
ATOM 1933 N N   . ASN A 1 285 ? 170.693 176.629 153.537 1.00 105.47 ? 285 ASN R N   1 
ATOM 1934 C CA  . ASN A 1 285 ? 171.642 176.487 154.636 1.00 105.47 ? 285 ASN R CA  1 
ATOM 1935 C C   . ASN A 1 285 ? 171.094 177.067 155.932 1.00 105.47 ? 285 ASN R C   1 
ATOM 1936 O O   . ASN A 1 285 ? 171.358 176.522 157.010 1.00 105.47 ? 285 ASN R O   1 
ATOM 1937 C CB  . ASN A 1 285 ? 172.968 177.155 154.282 1.00 105.47 ? 285 ASN R CB  1 
ATOM 1938 C CG  . ASN A 1 285 ? 174.041 176.894 155.316 1.00 105.47 ? 285 ASN R CG  1 
ATOM 1939 O OD1 . ASN A 1 285 ? 173.994 175.897 156.036 1.00 105.47 ? 285 ASN R OD1 1 
ATOM 1940 N ND2 . ASN A 1 285 ? 175.010 177.793 155.403 1.00 105.47 ? 285 ASN R ND2 1 
ATOM 1941 N N   . CYS A 1 286 ? 170.331 178.160 155.856 1.00 108.37 ? 286 CYS R N   1 
ATOM 1942 C CA  . CYS A 1 286 ? 169.775 178.758 157.063 1.00 108.37 ? 286 CYS R CA  1 
ATOM 1943 C C   . CYS A 1 286 ? 168.685 177.901 157.688 1.00 108.37 ? 286 CYS R C   1 
ATOM 1944 O O   . CYS A 1 286 ? 168.273 178.182 158.819 1.00 108.37 ? 286 CYS R O   1 
ATOM 1945 C CB  . CYS A 1 286 ? 169.224 180.155 156.767 1.00 108.37 ? 286 CYS R CB  1 
ATOM 1946 S SG  . CYS A 1 286 ? 167.635 180.184 155.916 1.00 108.37 ? 286 CYS R SG  1 
ATOM 1947 N N   . LEU A 1 287 ? 168.207 176.877 156.987 1.00 106.31 ? 287 LEU R N   1 
ATOM 1948 C CA  . LEU A 1 287 ? 167.309 175.895 157.575 1.00 106.31 ? 287 LEU R CA  1 
ATOM 1949 C C   . LEU A 1 287 ? 168.018 174.595 157.919 1.00 106.31 ? 287 LEU R C   1 
ATOM 1950 O O   . LEU A 1 287 ? 167.596 173.896 158.845 1.00 106.31 ? 287 LEU R O   1 
ATOM 1951 C CB  . LEU A 1 287 ? 166.136 175.618 156.623 1.00 106.31 ? 287 LEU R CB  1 
ATOM 1952 C CG  . LEU A 1 287 ? 164.946 174.754 157.057 1.00 106.31 ? 287 LEU R CG  1 
ATOM 1953 C CD1 . LEU A 1 287 ? 163.711 175.162 156.278 1.00 106.31 ? 287 LEU R CD1 1 
ATOM 1954 C CD2 . LEU A 1 287 ? 165.206 173.270 156.844 1.00 106.31 ? 287 LEU R CD2 1 
ATOM 1955 N N   . ALA A 1 288 ? 169.097 174.266 157.205 1.00 109.62 ? 288 ALA R N   1 
ATOM 1956 C CA  . ALA A 1 288 ? 169.849 173.054 157.498 1.00 109.62 ? 288 ALA R CA  1 
ATOM 1957 C C   . ALA A 1 288 ? 170.730 173.198 158.732 1.00 109.62 ? 288 ALA R C   1 
ATOM 1958 O O   . ALA A 1 288 ? 170.931 172.218 159.457 1.00 109.62 ? 288 ALA R O   1 
ATOM 1959 C CB  . ALA A 1 288 ? 170.705 172.663 156.293 1.00 109.62 ? 288 ALA R CB  1 
ATOM 1960 N N   . ASP A 1 289 ? 171.269 174.393 158.982 1.00 105.43 ? 289 ASP R N   1 
ATOM 1961 C CA  . ASP A 1 289 ? 172.168 174.575 160.121 1.00 105.43 ? 289 ASP R CA  1 
ATOM 1962 C C   . ASP A 1 289 ? 171.496 174.297 161.462 1.00 105.43 ? 289 ASP R C   1 
ATOM 1963 O O   . ASP A 1 289 ? 172.111 173.612 162.299 1.00 105.43 ? 289 ASP R O   1 
ATOM 1964 C CB  . ASP A 1 289 ? 172.785 175.977 160.072 1.00 105.43 ? 289 ASP R CB  1 
ATOM 1965 C CG  . ASP A 1 289 ? 174.068 176.020 159.267 1.00 105.43 ? 289 ASP R CG  1 
ATOM 1966 O OD1 . ASP A 1 289 ? 174.506 174.955 158.784 1.00 105.43 ? 289 ASP R OD1 1 
ATOM 1967 O OD2 . ASP A 1 289 ? 174.639 177.121 159.116 1.00 105.43 ? 289 ASP R OD2 1 
ATOM 1968 N N   . PRO A 1 290 ? 170.283 174.792 161.752 1.00 112.19 ? 290 PRO R N   1 
ATOM 1969 C CA  . PRO A 1 290 ? 169.631 174.377 163.007 1.00 112.19 ? 290 PRO R CA  1 
ATOM 1970 C C   . PRO A 1 290 ? 169.488 172.872 163.141 1.00 112.19 ? 290 PRO R C   1 
ATOM 1971 O O   . PRO A 1 290 ? 169.693 172.331 164.233 1.00 112.19 ? 290 PRO R O   1 
ATOM 1972 C CB  . PRO A 1 290 ? 168.256 175.057 162.946 1.00 112.19 ? 290 PRO R CB  1 
ATOM 1973 C CG  . PRO A 1 290 ? 168.287 175.998 161.822 1.00 112.19 ? 290 PRO R CG  1 
ATOM 1974 C CD  . PRO A 1 290 ? 169.597 175.936 161.125 1.00 112.19 ? 290 PRO R CD  1 
ATOM 1975 N N   . ALA A 1 291 ? 169.146 172.177 162.056 1.00 116.09 ? 291 ALA R N   1 
ATOM 1976 C CA  . ALA A 1 291 ? 168.964 170.732 162.136 1.00 116.09 ? 291 ALA R CA  1 
ATOM 1977 C C   . ALA A 1 291 ? 170.274 170.028 162.461 1.00 116.09 ? 291 ALA R C   1 
ATOM 1978 O O   . ALA A 1 291 ? 170.297 169.073 163.245 1.00 116.09 ? 291 ALA R O   1 
ATOM 1979 C CB  . ALA A 1 291 ? 168.378 170.204 160.827 1.00 116.09 ? 291 ALA R CB  1 
ATOM 1980 N N   . LEU A 1 292 ? 171.376 170.489 161.873 1.00 112.40 ? 292 LEU R N   1 
ATOM 1981 C CA  . LEU A 1 292 ? 172.666 169.844 162.069 1.00 112.40 ? 292 LEU R CA  1 
ATOM 1982 C C   . LEU A 1 292 ? 173.388 170.314 163.324 1.00 112.40 ? 292 LEU R C   1 
ATOM 1983 O O   . LEU A 1 292 ? 174.405 169.717 163.690 1.00 112.40 ? 292 LEU R O   1 
ATOM 1984 C CB  . LEU A 1 292 ? 173.557 170.083 160.850 1.00 112.40 ? 292 LEU R CB  1 
ATOM 1985 C CG  . LEU A 1 292 ? 173.029 169.544 159.521 1.00 112.40 ? 292 LEU R CG  1 
ATOM 1986 C CD1 . LEU A 1 292 ? 174.111 169.598 158.459 1.00 112.40 ? 292 LEU R CD1 1 
ATOM 1987 C CD2 . LEU A 1 292 ? 172.513 168.126 159.689 1.00 112.40 ? 292 LEU R CD2 1 
ATOM 1988 N N   . TYR A 1 293 ? 172.896 171.360 163.991 1.00 116.66 ? 293 TYR R N   1 
ATOM 1989 C CA  . TYR A 1 293 ? 173.553 171.879 165.180 1.00 116.66 ? 293 TYR R CA  1 
ATOM 1990 C C   . TYR A 1 293 ? 172.655 171.970 166.404 1.00 116.66 ? 293 TYR R C   1 
ATOM 1991 O O   . TYR A 1 293 ? 173.167 172.206 167.504 1.00 116.66 ? 293 TYR R O   1 
ATOM 1992 C CB  . TYR A 1 293 ? 174.151 173.261 164.889 1.00 116.66 ? 293 TYR R CB  1 
ATOM 1993 C CG  . TYR A 1 293 ? 175.310 173.214 163.925 1.00 116.66 ? 293 TYR R CG  1 
ATOM 1994 C CD1 . TYR A 1 293 ? 176.556 172.762 164.330 1.00 116.66 ? 293 TYR R CD1 1 
ATOM 1995 C CD2 . TYR A 1 293 ? 175.154 173.599 162.604 1.00 116.66 ? 293 TYR R CD2 1 
ATOM 1996 C CE1 . TYR A 1 293 ? 177.616 172.713 163.450 1.00 116.66 ? 293 TYR R CE1 1 
ATOM 1997 C CE2 . TYR A 1 293 ? 176.204 173.548 161.718 1.00 116.66 ? 293 TYR R CE2 1 
ATOM 1998 C CZ  . TYR A 1 293 ? 177.434 173.106 162.144 1.00 116.66 ? 293 TYR R CZ  1 
ATOM 1999 O OH  . TYR A 1 293 ? 178.484 173.057 161.258 1.00 116.66 ? 293 TYR R OH  1 
ATOM 2000 N N   . CYS A 1 294 ? 171.345 171.795 166.253 1.00 126.08 ? 294 CYS R N   1 
ATOM 2001 C CA  . CYS A 1 294 ? 170.429 171.737 167.385 1.00 126.08 ? 294 CYS R CA  1 
ATOM 2002 C C   . CYS A 1 294 ? 169.746 170.384 167.500 1.00 126.08 ? 294 CYS R C   1 
ATOM 2003 O O   . CYS A 1 294 ? 169.776 169.769 168.571 1.00 126.08 ? 294 CYS R O   1 
ATOM 2004 C CB  . CYS A 1 294 ? 169.382 172.858 167.272 1.00 126.08 ? 294 CYS R CB  1 
ATOM 2005 S SG  . CYS A 1 294 ? 168.012 172.753 168.441 1.00 126.08 ? 294 CYS R SG  1 
ATOM 2006 N N   . LEU A 1 295 ? 169.144 169.888 166.417 1.00 129.13 ? 295 LEU R N   1 
ATOM 2007 C CA  . LEU A 1 295 ? 168.533 168.565 166.450 1.00 129.13 ? 295 LEU R CA  1 
ATOM 2008 C C   . LEU A 1 295 ? 169.560 167.457 166.641 1.00 129.13 ? 295 LEU R C   1 
ATOM 2009 O O   . LEU A 1 295 ? 169.196 166.362 167.083 1.00 129.13 ? 295 LEU R O   1 
ATOM 2010 C CB  . LEU A 1 295 ? 167.737 168.320 165.168 1.00 129.13 ? 295 LEU R CB  1 
ATOM 2011 N N   . ALA A 1 296 ? 170.830 167.712 166.318 1.00 30.00  ? 296 ALA R N   1 
ATOM 2012 C CA  . ALA A 1 296 ? 171.865 166.704 166.522 1.00 30.00  ? 296 ALA R CA  1 
ATOM 2013 C C   . ALA A 1 296 ? 172.187 166.535 168.002 1.00 30.00  ? 296 ALA R C   1 
ATOM 2014 O O   . ALA A 1 296 ? 172.314 165.408 168.496 1.00 30.00  ? 296 ALA R O   1 
ATOM 2015 C CB  . ALA A 1 296 ? 173.121 167.075 165.735 1.00 30.00  ? 296 ALA R CB  1 
ATOM 2016 N N   . CYS A 1 297 ? 172.322 167.640 168.726 1.00 152.98 ? 297 CYS R N   1 
ATOM 2017 C CA  . CYS A 1 297 ? 172.686 167.576 170.137 1.00 152.98 ? 297 CYS R CA  1 
ATOM 2018 C C   . CYS A 1 297 ? 171.490 167.127 170.970 1.00 152.98 ? 297 CYS R C   1 
ATOM 2019 O O   . CYS A 1 297 ? 170.412 167.723 170.867 1.00 152.98 ? 297 CYS R O   1 
ATOM 2020 C CB  . CYS A 1 297 ? 173.182 168.934 170.624 1.00 152.98 ? 297 CYS R CB  1 
ATOM 2021 S SG  . CYS A 1 297 ? 173.447 169.036 172.410 1.00 152.98 ? 297 CYS R SG  1 
ATOM 2022 N N   . PRO A 1 298 ? 171.636 166.082 171.791 1.00 172.39 ? 298 PRO R N   1 
ATOM 2023 C CA  . PRO A 1 298 ? 170.509 165.655 172.642 1.00 172.39 ? 298 PRO R CA  1 
ATOM 2024 C C   . PRO A 1 298 ? 170.021 166.726 173.605 1.00 172.39 ? 298 PRO R C   1 
ATOM 2025 O O   . PRO A 1 298 ? 168.813 166.815 173.866 1.00 172.39 ? 298 PRO R O   1 
ATOM 2026 C CB  . PRO A 1 298 ? 171.081 164.442 173.387 1.00 172.39 ? 298 PRO R CB  1 
ATOM 2027 C CG  . PRO A 1 298 ? 172.184 163.938 172.512 1.00 172.39 ? 298 PRO R CG  1 
ATOM 2028 C CD  . PRO A 1 298 ? 172.771 165.145 171.845 1.00 172.39 ? 298 PRO R CD  1 
ATOM 2029 N N   . GLY A 1 299 ? 170.929 167.536 174.153 1.00 181.39 ? 299 GLY R N   1 
ATOM 2030 C CA  . GLY A 1 299 ? 170.514 168.563 175.096 1.00 181.39 ? 299 GLY R CA  1 
ATOM 2031 C C   . GLY A 1 299 ? 169.601 169.598 174.469 1.00 181.39 ? 299 GLY R C   1 
ATOM 2032 O O   . GLY A 1 299 ? 168.664 170.086 175.106 1.00 181.39 ? 299 GLY R O   1 
ATOM 2033 N N   . ALA A 1 300 ? 169.858 169.944 173.208 1.00 175.61 ? 300 ALA R N   1 
ATOM 2034 C CA  . ALA A 1 300 ? 168.970 170.869 172.518 1.00 175.61 ? 300 ALA R CA  1 
ATOM 2035 C C   . ALA A 1 300 ? 167.607 170.241 172.261 1.00 175.61 ? 300 ALA R C   1 
ATOM 2036 O O   . ALA A 1 300 ? 166.589 170.942 172.285 1.00 175.61 ? 300 ALA R O   1 
ATOM 2037 C CB  . ALA A 1 300 ? 169.612 171.335 171.215 1.00 175.61 ? 300 ALA R CB  1 
ATOM 2038 N N   . ARG A 1 301 ? 167.561 168.927 172.027 1.00 176.55 ? 301 ARG R N   1 
ATOM 2039 C CA  . ARG A 1 301 ? 166.276 168.239 171.934 1.00 176.55 ? 301 ARG R CA  1 
ATOM 2040 C C   . ARG A 1 301 ? 165.528 168.293 173.261 1.00 176.55 ? 301 ARG R C   1 
ATOM 2041 O O   . ARG A 1 301 ? 164.304 168.473 173.288 1.00 176.55 ? 301 ARG R O   1 
ATOM 2042 C CB  . ARG A 1 301 ? 166.485 166.792 171.491 1.00 176.55 ? 301 ARG R CB  1 
ATOM 2043 N N   . GLY A 1 302 ? 166.246 168.132 174.374 1.00 180.88 ? 302 GLY R N   1 
ATOM 2044 C CA  . GLY A 1 302 ? 165.614 168.283 175.676 1.00 180.88 ? 302 GLY R CA  1 
ATOM 2045 C C   . GLY A 1 302 ? 165.082 169.686 175.903 1.00 180.88 ? 302 GLY R C   1 
ATOM 2046 O O   . GLY A 1 302 ? 163.994 169.871 176.453 1.00 180.88 ? 302 GLY R O   1 
ATOM 2047 N N   . GLU A 1 303 ? 165.840 170.696 175.473 1.00 182.14 ? 303 GLU R N   1 
ATOM 2048 C CA  . GLU A 1 303 ? 165.357 172.070 175.579 1.00 182.14 ? 303 GLU R CA  1 
ATOM 2049 C C   . GLU A 1 303 ? 164.119 172.286 174.714 1.00 182.14 ? 303 GLU R C   1 
ATOM 2050 O O   . GLU A 1 303 ? 163.186 172.989 175.117 1.00 182.14 ? 303 GLU R O   1 
ATOM 2051 C CB  . GLU A 1 303 ? 166.467 173.051 175.196 1.00 182.14 ? 303 GLU R CB  1 
ATOM 2052 C CG  . GLU A 1 303 ? 166.113 174.526 175.383 1.00 182.14 ? 303 GLU R CG  1 
ATOM 2053 C CD  . GLU A 1 303 ? 165.160 174.775 176.543 1.00 182.14 ? 303 GLU R CD  1 
ATOM 2054 O OE1 . GLU A 1 303 ? 165.471 174.359 177.680 1.00 182.14 ? 303 GLU R OE1 1 
ATOM 2055 O OE2 . GLU A 1 303 ? 164.100 175.397 176.317 1.00 182.14 ? 303 GLU R OE2 1 
ATOM 2056 N N   . VAL A 1 304 ? 164.097 171.692 173.519 1.00 177.85 ? 304 VAL R N   1 
ATOM 2057 C CA  . VAL A 1 304 ? 162.916 171.776 172.662 1.00 177.85 ? 304 VAL R CA  1 
ATOM 2058 C C   . VAL A 1 304 ? 161.714 171.143 173.349 1.00 177.85 ? 304 VAL R C   1 
ATOM 2059 O O   . VAL A 1 304 ? 160.602 171.685 173.316 1.00 177.85 ? 304 VAL R O   1 
ATOM 2060 C CB  . VAL A 1 304 ? 163.197 171.121 171.298 1.00 177.85 ? 304 VAL R CB  1 
ATOM 2061 N N   . ALA A 1 305 ? 161.914 169.980 173.975 1.00 183.51 ? 305 ALA R N   1 
ATOM 2062 C CA  . ALA A 1 305 ? 160.848 169.358 174.752 1.00 183.51 ? 305 ALA R CA  1 
ATOM 2063 C C   . ALA A 1 305 ? 160.453 170.200 175.959 1.00 183.51 ? 305 ALA R C   1 
ATOM 2064 O O   . ALA A 1 305 ? 159.341 170.048 176.472 1.00 183.51 ? 305 ALA R O   1 
ATOM 2065 C CB  . ALA A 1 305 ? 161.271 167.960 175.205 1.00 183.51 ? 305 ALA R CB  1 
ATOM 2066 N N   . LYS A 1 306 ? 161.348 171.066 176.431 1.00 185.58 ? 306 LYS R N   1 
ATOM 2067 C CA  . LYS A 1 306 ? 160.986 172.026 177.467 1.00 185.58 ? 306 LYS R CA  1 
ATOM 2068 C C   . LYS A 1 306 ? 160.164 173.182 176.908 1.00 185.58 ? 306 LYS R C   1 
ATOM 2069 O O   . LYS A 1 306 ? 159.329 173.747 177.624 1.00 185.58 ? 306 LYS R O   1 
ATOM 2070 C CB  . LYS A 1 306 ? 162.244 172.563 178.154 1.00 185.58 ? 306 LYS R CB  1 
ATOM 2071 C CG  . LYS A 1 306 ? 161.990 173.314 179.457 1.00 185.58 ? 306 LYS R CG  1 
ATOM 2072 C CD  . LYS A 1 306 ? 160.929 172.641 180.318 1.00 185.58 ? 306 LYS R CD  1 
ATOM 2073 C CE  . LYS A 1 306 ? 161.436 171.342 180.923 1.00 185.58 ? 306 LYS R CE  1 
ATOM 2074 N NZ  . LYS A 1 306 ? 160.596 170.902 182.069 1.00 185.58 ? 306 LYS R NZ  1 
ATOM 2075 N N   . VAL A 1 307 ? 160.390 173.546 175.643 1.00 189.87 ? 307 VAL R N   1 
ATOM 2076 C CA  . VAL A 1 307 ? 159.670 174.668 175.043 1.00 189.87 ? 307 VAL R CA  1 
ATOM 2077 C C   . VAL A 1 307 ? 158.174 174.388 175.003 1.00 189.87 ? 307 VAL R C   1 
ATOM 2078 O O   . VAL A 1 307 ? 157.356 175.252 175.341 1.00 189.87 ? 307 VAL R O   1 
ATOM 2079 C CB  . VAL A 1 307 ? 160.227 174.970 173.639 1.00 189.87 ? 307 VAL R CB  1 
ATOM 2080 C CG1 . VAL A 1 307 ? 159.335 175.965 172.912 1.00 189.87 ? 307 VAL R CG1 1 
ATOM 2081 C CG2 . VAL A 1 307 ? 161.650 175.496 173.733 1.00 189.87 ? 307 VAL R CG2 1 
ATOM 2082 N N   . VAL A 1 308 ? 157.791 173.181 174.598 1.00 197.66 ? 308 VAL R N   1 
ATOM 2083 C CA  . VAL A 1 308 ? 156.382 172.814 174.517 1.00 197.66 ? 308 VAL R CA  1 
ATOM 2084 C C   . VAL A 1 308 ? 155.765 172.750 175.908 1.00 197.66 ? 308 VAL R C   1 
ATOM 2085 O O   . VAL A 1 308 ? 154.603 172.382 176.062 1.00 197.66 ? 308 VAL R O   1 
ATOM 2086 C CB  . VAL A 1 308 ? 156.194 171.474 173.783 1.00 197.66 ? 308 VAL R CB  1 
ATOM 2087 C CG1 . VAL A 1 308 ? 156.785 171.546 172.382 1.00 197.66 ? 308 VAL R CG1 1 
ATOM 2088 C CG2 . VAL A 1 308 ? 156.819 170.340 174.579 1.00 197.66 ? 308 VAL R CG2 1 
# 
