data_8ZEV
# 
_entry.id   8ZEV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZEV         pdb_00008zev 10.2210/pdb8zev/pdb 
WWPDB D_1300047628 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-19 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZEV 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-07 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              liangzhang2014@sjtu.edu.cn 
_pdbx_contact_author.name_first         Liang 
_pdbx_contact_author.name_last          Zhang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7672-1168 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, L.' 1 ? 
'Zhang, L.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   GE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Chembiochem 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1439-7633 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            25 
_citation.language                  ? 
_citation.page_first                e202400466 
_citation.page_last                 e202400466 
_citation.title                     'Structural Basis of the Dehydratase Module (hDH) of Human Fatty Acid Synthase.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/cbic.202400466 
_citation.pdbx_database_id_PubMed   38955950 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Cai, C.'   1 ?                   
primary 'Huang, Y.' 2 ?                   
primary 'Zhang, L.' 3 ?                   
primary 'Zhang, L.' 4 0000-0002-7672-1168 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Fatty acid synthase' 28096.709 4   2.3.1.85,2.3.1.38,2.3.1.39,2.3.1.41,1.1.1.100,4.2.1.59,1.3.1.39,3.1.2.14 ? 
'dehydratase domain' ? 
2 non-polymer syn 'IODIDE ION'          126.904   7   ?                                                                        ? ? 
? 
3 water       nat water                 18.015    747 ?                                                                        ? ? 
? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Type I fatty acid synthase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SENLYFQSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGT
VSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILE
ASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAG
GVHISGLHTESA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SENLYFQSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGT
VSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILE
ASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAG
GVHISGLHTESA
;
_entity_poly.pdbx_strand_id                 A,B,C,D 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'IODIDE ION' IOD 
3 water        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLU n 
1 3   ASN n 
1 4   LEU n 
1 5   TYR n 
1 6   PHE n 
1 7   GLN n 
1 8   SER n 
1 9   ALA n 
1 10  ALA n 
1 11  ILE n 
1 12  TYR n 
1 13  ASN n 
1 14  ILE n 
1 15  ASP n 
1 16  THR n 
1 17  SER n 
1 18  SER n 
1 19  GLU n 
1 20  SER n 
1 21  PRO n 
1 22  ASP n 
1 23  HIS n 
1 24  TYR n 
1 25  LEU n 
1 26  VAL n 
1 27  ASP n 
1 28  HIS n 
1 29  THR n 
1 30  LEU n 
1 31  ASP n 
1 32  GLY n 
1 33  ARG n 
1 34  VAL n 
1 35  LEU n 
1 36  PHE n 
1 37  PRO n 
1 38  ALA n 
1 39  THR n 
1 40  GLY n 
1 41  TYR n 
1 42  LEU n 
1 43  SER n 
1 44  ILE n 
1 45  VAL n 
1 46  TRP n 
1 47  LYS n 
1 48  THR n 
1 49  LEU n 
1 50  ALA n 
1 51  ARG n 
1 52  ALA n 
1 53  LEU n 
1 54  GLY n 
1 55  LEU n 
1 56  GLY n 
1 57  VAL n 
1 58  GLU n 
1 59  GLN n 
1 60  LEU n 
1 61  PRO n 
1 62  VAL n 
1 63  VAL n 
1 64  PHE n 
1 65  GLU n 
1 66  ASP n 
1 67  VAL n 
1 68  VAL n 
1 69  LEU n 
1 70  HIS n 
1 71  GLN n 
1 72  ALA n 
1 73  THR n 
1 74  ILE n 
1 75  LEU n 
1 76  PRO n 
1 77  LYS n 
1 78  THR n 
1 79  GLY n 
1 80  THR n 
1 81  VAL n 
1 82  SER n 
1 83  LEU n 
1 84  GLU n 
1 85  VAL n 
1 86  ARG n 
1 87  LEU n 
1 88  LEU n 
1 89  GLU n 
1 90  ALA n 
1 91  SER n 
1 92  ARG n 
1 93  ALA n 
1 94  PHE n 
1 95  GLU n 
1 96  VAL n 
1 97  SER n 
1 98  GLU n 
1 99  ASN n 
1 100 GLY n 
1 101 ASN n 
1 102 LEU n 
1 103 VAL n 
1 104 VAL n 
1 105 SER n 
1 106 GLY n 
1 107 LYS n 
1 108 VAL n 
1 109 TYR n 
1 110 GLN n 
1 111 TRP n 
1 112 ASP n 
1 113 ASP n 
1 114 PRO n 
1 115 ASP n 
1 116 PRO n 
1 117 ARG n 
1 118 LEU n 
1 119 PHE n 
1 120 ASP n 
1 121 HIS n 
1 122 PRO n 
1 123 GLU n 
1 124 SER n 
1 125 PRO n 
1 126 THR n 
1 127 PRO n 
1 128 ASN n 
1 129 PRO n 
1 130 THR n 
1 131 GLU n 
1 132 PRO n 
1 133 LEU n 
1 134 PHE n 
1 135 LEU n 
1 136 ALA n 
1 137 GLN n 
1 138 ALA n 
1 139 GLU n 
1 140 VAL n 
1 141 TYR n 
1 142 LYS n 
1 143 GLU n 
1 144 LEU n 
1 145 ARG n 
1 146 LEU n 
1 147 ARG n 
1 148 GLY n 
1 149 TYR n 
1 150 ASP n 
1 151 TYR n 
1 152 GLY n 
1 153 PRO n 
1 154 HIS n 
1 155 PHE n 
1 156 GLN n 
1 157 GLY n 
1 158 ILE n 
1 159 LEU n 
1 160 GLU n 
1 161 ALA n 
1 162 SER n 
1 163 LEU n 
1 164 GLU n 
1 165 GLY n 
1 166 ASP n 
1 167 SER n 
1 168 GLY n 
1 169 ARG n 
1 170 LEU n 
1 171 LEU n 
1 172 TRP n 
1 173 LYS n 
1 174 ASP n 
1 175 ASN n 
1 176 TRP n 
1 177 VAL n 
1 178 SER n 
1 179 PHE n 
1 180 MET n 
1 181 ASP n 
1 182 THR n 
1 183 MET n 
1 184 LEU n 
1 185 GLN n 
1 186 MET n 
1 187 SER n 
1 188 ILE n 
1 189 LEU n 
1 190 GLY n 
1 191 SER n 
1 192 ALA n 
1 193 LYS n 
1 194 HIS n 
1 195 GLY n 
1 196 LEU n 
1 197 TYR n 
1 198 LEU n 
1 199 PRO n 
1 200 THR n 
1 201 ARG n 
1 202 VAL n 
1 203 THR n 
1 204 ALA n 
1 205 ILE n 
1 206 HIS n 
1 207 ILE n 
1 208 ASP n 
1 209 PRO n 
1 210 ALA n 
1 211 THR n 
1 212 HIS n 
1 213 ARG n 
1 214 GLN n 
1 215 LYS n 
1 216 LEU n 
1 217 TYR n 
1 218 THR n 
1 219 LEU n 
1 220 GLN n 
1 221 ASP n 
1 222 LYS n 
1 223 ALA n 
1 224 GLN n 
1 225 VAL n 
1 226 ALA n 
1 227 ASP n 
1 228 VAL n 
1 229 VAL n 
1 230 VAL n 
1 231 SER n 
1 232 ARG n 
1 233 TRP n 
1 234 LEU n 
1 235 ARG n 
1 236 VAL n 
1 237 THR n 
1 238 VAL n 
1 239 ALA n 
1 240 GLY n 
1 241 GLY n 
1 242 VAL n 
1 243 HIS n 
1 244 ILE n 
1 245 SER n 
1 246 GLY n 
1 247 LEU n 
1 248 HIS n 
1 249 THR n 
1 250 GLU n 
1 251 SER n 
1 252 ALA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   252 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'FASN, FAS' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
IOD non-polymer         . 'IODIDE ION'    ? 'I -1'           126.904 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   -7   -7   SER SER A . n 
A 1 2   GLU 2   -6   -6   GLU GLU A . n 
A 1 3   ASN 3   -5   -5   ASN ASN A . n 
A 1 4   LEU 4   -4   -4   LEU LEU A . n 
A 1 5   TYR 5   -3   -3   TYR TYR A . n 
A 1 6   PHE 6   -2   -2   PHE PHE A . n 
A 1 7   GLN 7   -1   -1   GLN GLN A . n 
A 1 8   SER 8   858  858  SER SER A . n 
A 1 9   ALA 9   859  859  ALA ALA A . n 
A 1 10  ALA 10  860  860  ALA ALA A . n 
A 1 11  ILE 11  861  861  ILE ILE A . n 
A 1 12  TYR 12  862  862  TYR TYR A . n 
A 1 13  ASN 13  863  863  ASN ASN A . n 
A 1 14  ILE 14  864  864  ILE ILE A . n 
A 1 15  ASP 15  865  865  ASP ASP A . n 
A 1 16  THR 16  866  866  THR THR A . n 
A 1 17  SER 17  867  867  SER SER A . n 
A 1 18  SER 18  868  868  SER SER A . n 
A 1 19  GLU 19  869  869  GLU GLU A . n 
A 1 20  SER 20  870  870  SER SER A . n 
A 1 21  PRO 21  871  871  PRO PRO A . n 
A 1 22  ASP 22  872  872  ASP ASP A . n 
A 1 23  HIS 23  873  873  HIS HIS A . n 
A 1 24  TYR 24  874  874  TYR TYR A . n 
A 1 25  LEU 25  875  875  LEU LEU A . n 
A 1 26  VAL 26  876  876  VAL VAL A . n 
A 1 27  ASP 27  877  877  ASP ASP A . n 
A 1 28  HIS 28  878  878  HIS HIS A . n 
A 1 29  THR 29  879  879  THR THR A . n 
A 1 30  LEU 30  880  880  LEU LEU A . n 
A 1 31  ASP 31  881  881  ASP ASP A . n 
A 1 32  GLY 32  882  882  GLY GLY A . n 
A 1 33  ARG 33  883  883  ARG ARG A . n 
A 1 34  VAL 34  884  884  VAL VAL A . n 
A 1 35  LEU 35  885  885  LEU LEU A . n 
A 1 36  PHE 36  886  886  PHE PHE A . n 
A 1 37  PRO 37  887  887  PRO PRO A . n 
A 1 38  ALA 38  888  888  ALA ALA A . n 
A 1 39  THR 39  889  889  THR THR A . n 
A 1 40  GLY 40  890  890  GLY GLY A . n 
A 1 41  TYR 41  891  891  TYR TYR A . n 
A 1 42  LEU 42  892  892  LEU LEU A . n 
A 1 43  SER 43  893  893  SER SER A . n 
A 1 44  ILE 44  894  894  ILE ILE A . n 
A 1 45  VAL 45  895  895  VAL VAL A . n 
A 1 46  TRP 46  896  896  TRP TRP A . n 
A 1 47  LYS 47  897  897  LYS LYS A . n 
A 1 48  THR 48  898  898  THR THR A . n 
A 1 49  LEU 49  899  899  LEU LEU A . n 
A 1 50  ALA 50  900  900  ALA ALA A . n 
A 1 51  ARG 51  901  901  ARG ARG A . n 
A 1 52  ALA 52  902  902  ALA ALA A . n 
A 1 53  LEU 53  903  903  LEU LEU A . n 
A 1 54  GLY 54  904  904  GLY GLY A . n 
A 1 55  LEU 55  905  905  LEU LEU A . n 
A 1 56  GLY 56  906  906  GLY GLY A . n 
A 1 57  VAL 57  907  907  VAL VAL A . n 
A 1 58  GLU 58  908  908  GLU GLU A . n 
A 1 59  GLN 59  909  909  GLN GLN A . n 
A 1 60  LEU 60  910  910  LEU LEU A . n 
A 1 61  PRO 61  911  911  PRO PRO A . n 
A 1 62  VAL 62  912  912  VAL VAL A . n 
A 1 63  VAL 63  913  913  VAL VAL A . n 
A 1 64  PHE 64  914  914  PHE PHE A . n 
A 1 65  GLU 65  915  915  GLU GLU A . n 
A 1 66  ASP 66  916  916  ASP ASP A . n 
A 1 67  VAL 67  917  917  VAL VAL A . n 
A 1 68  VAL 68  918  918  VAL VAL A . n 
A 1 69  LEU 69  919  919  LEU LEU A . n 
A 1 70  HIS 70  920  920  HIS HIS A . n 
A 1 71  GLN 71  921  921  GLN GLN A . n 
A 1 72  ALA 72  922  922  ALA ALA A . n 
A 1 73  THR 73  923  923  THR THR A . n 
A 1 74  ILE 74  924  924  ILE ILE A . n 
A 1 75  LEU 75  925  925  LEU LEU A . n 
A 1 76  PRO 76  926  926  PRO PRO A . n 
A 1 77  LYS 77  927  927  LYS LYS A . n 
A 1 78  THR 78  928  928  THR THR A . n 
A 1 79  GLY 79  929  929  GLY GLY A . n 
A 1 80  THR 80  930  930  THR THR A . n 
A 1 81  VAL 81  931  931  VAL VAL A . n 
A 1 82  SER 82  932  932  SER SER A . n 
A 1 83  LEU 83  933  933  LEU LEU A . n 
A 1 84  GLU 84  934  934  GLU GLU A . n 
A 1 85  VAL 85  935  935  VAL VAL A . n 
A 1 86  ARG 86  936  936  ARG ARG A . n 
A 1 87  LEU 87  937  937  LEU LEU A . n 
A 1 88  LEU 88  938  938  LEU LEU A . n 
A 1 89  GLU 89  939  939  GLU GLU A . n 
A 1 90  ALA 90  940  940  ALA ALA A . n 
A 1 91  SER 91  941  941  SER SER A . n 
A 1 92  ARG 92  942  942  ARG ARG A . n 
A 1 93  ALA 93  943  943  ALA ALA A . n 
A 1 94  PHE 94  944  944  PHE PHE A . n 
A 1 95  GLU 95  945  945  GLU GLU A . n 
A 1 96  VAL 96  946  946  VAL VAL A . n 
A 1 97  SER 97  947  947  SER SER A . n 
A 1 98  GLU 98  948  948  GLU GLU A . n 
A 1 99  ASN 99  949  949  ASN ASN A . n 
A 1 100 GLY 100 950  950  GLY GLY A . n 
A 1 101 ASN 101 951  951  ASN ASN A . n 
A 1 102 LEU 102 952  952  LEU LEU A . n 
A 1 103 VAL 103 953  953  VAL VAL A . n 
A 1 104 VAL 104 954  954  VAL VAL A . n 
A 1 105 SER 105 955  955  SER SER A . n 
A 1 106 GLY 106 956  956  GLY GLY A . n 
A 1 107 LYS 107 957  957  LYS LYS A . n 
A 1 108 VAL 108 958  958  VAL VAL A . n 
A 1 109 TYR 109 959  959  TYR TYR A . n 
A 1 110 GLN 110 960  960  GLN GLN A . n 
A 1 111 TRP 111 961  961  TRP TRP A . n 
A 1 112 ASP 112 962  962  ASP ASP A . n 
A 1 113 ASP 113 963  963  ASP ASP A . n 
A 1 114 PRO 114 964  964  PRO PRO A . n 
A 1 115 ASP 115 965  965  ASP ASP A . n 
A 1 116 PRO 116 966  966  PRO PRO A . n 
A 1 117 ARG 117 967  967  ARG ARG A . n 
A 1 118 LEU 118 968  968  LEU LEU A . n 
A 1 119 PHE 119 969  969  PHE PHE A . n 
A 1 120 ASP 120 970  970  ASP ASP A . n 
A 1 121 HIS 121 971  971  HIS HIS A . n 
A 1 122 PRO 122 972  972  PRO PRO A . n 
A 1 123 GLU 123 973  973  GLU GLU A . n 
A 1 124 SER 124 974  974  SER SER A . n 
A 1 125 PRO 125 975  975  PRO PRO A . n 
A 1 126 THR 126 976  976  THR THR A . n 
A 1 127 PRO 127 977  977  PRO PRO A . n 
A 1 128 ASN 128 978  978  ASN ASN A . n 
A 1 129 PRO 129 979  979  PRO PRO A . n 
A 1 130 THR 130 980  980  THR THR A . n 
A 1 131 GLU 131 981  981  GLU GLU A . n 
A 1 132 PRO 132 982  982  PRO PRO A . n 
A 1 133 LEU 133 983  983  LEU LEU A . n 
A 1 134 PHE 134 984  984  PHE PHE A . n 
A 1 135 LEU 135 985  985  LEU LEU A . n 
A 1 136 ALA 136 986  986  ALA ALA A . n 
A 1 137 GLN 137 987  987  GLN GLN A . n 
A 1 138 ALA 138 988  988  ALA ALA A . n 
A 1 139 GLU 139 989  989  GLU GLU A . n 
A 1 140 VAL 140 990  990  VAL VAL A . n 
A 1 141 TYR 141 991  991  TYR TYR A . n 
A 1 142 LYS 142 992  992  LYS LYS A . n 
A 1 143 GLU 143 993  993  GLU GLU A . n 
A 1 144 LEU 144 994  994  LEU LEU A . n 
A 1 145 ARG 145 995  995  ARG ARG A . n 
A 1 146 LEU 146 996  996  LEU LEU A . n 
A 1 147 ARG 147 997  997  ARG ARG A . n 
A 1 148 GLY 148 998  998  GLY GLY A . n 
A 1 149 TYR 149 999  999  TYR TYR A . n 
A 1 150 ASP 150 1000 1000 ASP ASP A . n 
A 1 151 TYR 151 1001 1001 TYR TYR A . n 
A 1 152 GLY 152 1002 1002 GLY GLY A . n 
A 1 153 PRO 153 1003 1003 PRO PRO A . n 
A 1 154 HIS 154 1004 1004 HIS HIS A . n 
A 1 155 PHE 155 1005 1005 PHE PHE A . n 
A 1 156 GLN 156 1006 1006 GLN GLN A . n 
A 1 157 GLY 157 1007 1007 GLY GLY A . n 
A 1 158 ILE 158 1008 1008 ILE ILE A . n 
A 1 159 LEU 159 1009 1009 LEU LEU A . n 
A 1 160 GLU 160 1010 1010 GLU GLU A . n 
A 1 161 ALA 161 1011 1011 ALA ALA A . n 
A 1 162 SER 162 1012 1012 SER SER A . n 
A 1 163 LEU 163 1013 1013 LEU LEU A . n 
A 1 164 GLU 164 1014 1014 GLU GLU A . n 
A 1 165 GLY 165 1015 1015 GLY GLY A . n 
A 1 166 ASP 166 1016 1016 ASP ASP A . n 
A 1 167 SER 167 1017 1017 SER SER A . n 
A 1 168 GLY 168 1018 1018 GLY GLY A . n 
A 1 169 ARG 169 1019 1019 ARG ARG A . n 
A 1 170 LEU 170 1020 1020 LEU LEU A . n 
A 1 171 LEU 171 1021 1021 LEU LEU A . n 
A 1 172 TRP 172 1022 1022 TRP TRP A . n 
A 1 173 LYS 173 1023 1023 LYS LYS A . n 
A 1 174 ASP 174 1024 1024 ASP ASP A . n 
A 1 175 ASN 175 1025 1025 ASN ASN A . n 
A 1 176 TRP 176 1026 1026 TRP TRP A . n 
A 1 177 VAL 177 1027 1027 VAL VAL A . n 
A 1 178 SER 178 1028 1028 SER SER A . n 
A 1 179 PHE 179 1029 1029 PHE PHE A . n 
A 1 180 MET 180 1030 1030 MET MET A . n 
A 1 181 ASP 181 1031 1031 ASP ASP A . n 
A 1 182 THR 182 1032 1032 THR THR A . n 
A 1 183 MET 183 1033 1033 MET MET A . n 
A 1 184 LEU 184 1034 1034 LEU LEU A . n 
A 1 185 GLN 185 1035 1035 GLN GLN A . n 
A 1 186 MET 186 1036 1036 MET MET A . n 
A 1 187 SER 187 1037 1037 SER SER A . n 
A 1 188 ILE 188 1038 1038 ILE ILE A . n 
A 1 189 LEU 189 1039 1039 LEU LEU A . n 
A 1 190 GLY 190 1040 1040 GLY GLY A . n 
A 1 191 SER 191 1041 1041 SER SER A . n 
A 1 192 ALA 192 1042 1042 ALA ALA A . n 
A 1 193 LYS 193 1043 1043 LYS LYS A . n 
A 1 194 HIS 194 1044 1044 HIS HIS A . n 
A 1 195 GLY 195 1045 1045 GLY GLY A . n 
A 1 196 LEU 196 1046 1046 LEU LEU A . n 
A 1 197 TYR 197 1047 1047 TYR TYR A . n 
A 1 198 LEU 198 1048 1048 LEU LEU A . n 
A 1 199 PRO 199 1049 1049 PRO PRO A . n 
A 1 200 THR 200 1050 1050 THR THR A . n 
A 1 201 ARG 201 1051 1051 ARG ARG A . n 
A 1 202 VAL 202 1052 1052 VAL VAL A . n 
A 1 203 THR 203 1053 1053 THR THR A . n 
A 1 204 ALA 204 1054 1054 ALA ALA A . n 
A 1 205 ILE 205 1055 1055 ILE ILE A . n 
A 1 206 HIS 206 1056 1056 HIS HIS A . n 
A 1 207 ILE 207 1057 1057 ILE ILE A . n 
A 1 208 ASP 208 1058 1058 ASP ASP A . n 
A 1 209 PRO 209 1059 1059 PRO PRO A . n 
A 1 210 ALA 210 1060 1060 ALA ALA A . n 
A 1 211 THR 211 1061 1061 THR THR A . n 
A 1 212 HIS 212 1062 1062 HIS HIS A . n 
A 1 213 ARG 213 1063 1063 ARG ARG A . n 
A 1 214 GLN 214 1064 1064 GLN GLN A . n 
A 1 215 LYS 215 1065 1065 LYS LYS A . n 
A 1 216 LEU 216 1066 1066 LEU LEU A . n 
A 1 217 TYR 217 1067 1067 TYR TYR A . n 
A 1 218 THR 218 1068 1068 THR THR A . n 
A 1 219 LEU 219 1069 1069 LEU LEU A . n 
A 1 220 GLN 220 1070 1070 GLN GLN A . n 
A 1 221 ASP 221 1071 1071 ASP ASP A . n 
A 1 222 LYS 222 1072 1072 LYS LYS A . n 
A 1 223 ALA 223 1073 1073 ALA ALA A . n 
A 1 224 GLN 224 1074 1074 GLN GLN A . n 
A 1 225 VAL 225 1075 1075 VAL VAL A . n 
A 1 226 ALA 226 1076 1076 ALA ALA A . n 
A 1 227 ASP 227 1077 1077 ASP ASP A . n 
A 1 228 VAL 228 1078 1078 VAL VAL A . n 
A 1 229 VAL 229 1079 1079 VAL VAL A . n 
A 1 230 VAL 230 1080 1080 VAL VAL A . n 
A 1 231 SER 231 1081 1081 SER SER A . n 
A 1 232 ARG 232 1082 1082 ARG ARG A . n 
A 1 233 TRP 233 1083 1083 TRP TRP A . n 
A 1 234 LEU 234 1084 1084 LEU LEU A . n 
A 1 235 ARG 235 1085 1085 ARG ARG A . n 
A 1 236 VAL 236 1086 1086 VAL VAL A . n 
A 1 237 THR 237 1087 1087 THR THR A . n 
A 1 238 VAL 238 1088 1088 VAL VAL A . n 
A 1 239 ALA 239 1089 1089 ALA ALA A . n 
A 1 240 GLY 240 1090 1090 GLY GLY A . n 
A 1 241 GLY 241 1091 1091 GLY GLY A . n 
A 1 242 VAL 242 1092 1092 VAL VAL A . n 
A 1 243 HIS 243 1093 1093 HIS HIS A . n 
A 1 244 ILE 244 1094 1094 ILE ILE A . n 
A 1 245 SER 245 1095 1095 SER SER A . n 
A 1 246 GLY 246 1096 1096 GLY GLY A . n 
A 1 247 LEU 247 1097 1097 LEU LEU A . n 
A 1 248 HIS 248 1098 1098 HIS HIS A . n 
A 1 249 THR 249 1099 1099 THR THR A . n 
A 1 250 GLU 250 1100 1100 GLU GLU A . n 
A 1 251 SER 251 1101 1101 SER SER A . n 
A 1 252 ALA 252 1102 1102 ALA ALA A . n 
B 1 1   SER 1   -7   -7   SER SER B . n 
B 1 2   GLU 2   -6   -6   GLU GLU B . n 
B 1 3   ASN 3   -5   -5   ASN ASN B . n 
B 1 4   LEU 4   -4   -4   LEU LEU B . n 
B 1 5   TYR 5   -3   -3   TYR TYR B . n 
B 1 6   PHE 6   -2   -2   PHE PHE B . n 
B 1 7   GLN 7   -1   -1   GLN GLN B . n 
B 1 8   SER 8   858  858  SER SER B . n 
B 1 9   ALA 9   859  859  ALA ALA B . n 
B 1 10  ALA 10  860  860  ALA ALA B . n 
B 1 11  ILE 11  861  861  ILE ILE B . n 
B 1 12  TYR 12  862  862  TYR TYR B . n 
B 1 13  ASN 13  863  863  ASN ASN B . n 
B 1 14  ILE 14  864  864  ILE ILE B . n 
B 1 15  ASP 15  865  865  ASP ASP B . n 
B 1 16  THR 16  866  866  THR THR B . n 
B 1 17  SER 17  867  867  SER SER B . n 
B 1 18  SER 18  868  868  SER SER B . n 
B 1 19  GLU 19  869  869  GLU GLU B . n 
B 1 20  SER 20  870  870  SER SER B . n 
B 1 21  PRO 21  871  871  PRO PRO B . n 
B 1 22  ASP 22  872  872  ASP ASP B . n 
B 1 23  HIS 23  873  873  HIS HIS B . n 
B 1 24  TYR 24  874  874  TYR TYR B . n 
B 1 25  LEU 25  875  875  LEU LEU B . n 
B 1 26  VAL 26  876  876  VAL VAL B . n 
B 1 27  ASP 27  877  877  ASP ASP B . n 
B 1 28  HIS 28  878  878  HIS HIS B . n 
B 1 29  THR 29  879  879  THR THR B . n 
B 1 30  LEU 30  880  880  LEU LEU B . n 
B 1 31  ASP 31  881  881  ASP ASP B . n 
B 1 32  GLY 32  882  882  GLY GLY B . n 
B 1 33  ARG 33  883  883  ARG ARG B . n 
B 1 34  VAL 34  884  884  VAL VAL B . n 
B 1 35  LEU 35  885  885  LEU LEU B . n 
B 1 36  PHE 36  886  886  PHE PHE B . n 
B 1 37  PRO 37  887  887  PRO PRO B . n 
B 1 38  ALA 38  888  888  ALA ALA B . n 
B 1 39  THR 39  889  889  THR THR B . n 
B 1 40  GLY 40  890  890  GLY GLY B . n 
B 1 41  TYR 41  891  891  TYR TYR B . n 
B 1 42  LEU 42  892  892  LEU LEU B . n 
B 1 43  SER 43  893  893  SER SER B . n 
B 1 44  ILE 44  894  894  ILE ILE B . n 
B 1 45  VAL 45  895  895  VAL VAL B . n 
B 1 46  TRP 46  896  896  TRP TRP B . n 
B 1 47  LYS 47  897  897  LYS LYS B . n 
B 1 48  THR 48  898  898  THR THR B . n 
B 1 49  LEU 49  899  899  LEU LEU B . n 
B 1 50  ALA 50  900  900  ALA ALA B . n 
B 1 51  ARG 51  901  901  ARG ARG B . n 
B 1 52  ALA 52  902  902  ALA ALA B . n 
B 1 53  LEU 53  903  903  LEU LEU B . n 
B 1 54  GLY 54  904  904  GLY GLY B . n 
B 1 55  LEU 55  905  905  LEU LEU B . n 
B 1 56  GLY 56  906  906  GLY GLY B . n 
B 1 57  VAL 57  907  907  VAL VAL B . n 
B 1 58  GLU 58  908  908  GLU GLU B . n 
B 1 59  GLN 59  909  909  GLN GLN B . n 
B 1 60  LEU 60  910  910  LEU LEU B . n 
B 1 61  PRO 61  911  911  PRO PRO B . n 
B 1 62  VAL 62  912  912  VAL VAL B . n 
B 1 63  VAL 63  913  913  VAL VAL B . n 
B 1 64  PHE 64  914  914  PHE PHE B . n 
B 1 65  GLU 65  915  915  GLU GLU B . n 
B 1 66  ASP 66  916  916  ASP ASP B . n 
B 1 67  VAL 67  917  917  VAL VAL B . n 
B 1 68  VAL 68  918  918  VAL VAL B . n 
B 1 69  LEU 69  919  919  LEU LEU B . n 
B 1 70  HIS 70  920  920  HIS HIS B . n 
B 1 71  GLN 71  921  921  GLN GLN B . n 
B 1 72  ALA 72  922  922  ALA ALA B . n 
B 1 73  THR 73  923  923  THR THR B . n 
B 1 74  ILE 74  924  924  ILE ILE B . n 
B 1 75  LEU 75  925  925  LEU LEU B . n 
B 1 76  PRO 76  926  926  PRO PRO B . n 
B 1 77  LYS 77  927  927  LYS LYS B . n 
B 1 78  THR 78  928  928  THR THR B . n 
B 1 79  GLY 79  929  929  GLY GLY B . n 
B 1 80  THR 80  930  930  THR THR B . n 
B 1 81  VAL 81  931  931  VAL VAL B . n 
B 1 82  SER 82  932  932  SER SER B . n 
B 1 83  LEU 83  933  933  LEU LEU B . n 
B 1 84  GLU 84  934  934  GLU GLU B . n 
B 1 85  VAL 85  935  935  VAL VAL B . n 
B 1 86  ARG 86  936  936  ARG ARG B . n 
B 1 87  LEU 87  937  937  LEU LEU B . n 
B 1 88  LEU 88  938  938  LEU LEU B . n 
B 1 89  GLU 89  939  939  GLU GLU B . n 
B 1 90  ALA 90  940  940  ALA ALA B . n 
B 1 91  SER 91  941  941  SER SER B . n 
B 1 92  ARG 92  942  942  ARG ARG B . n 
B 1 93  ALA 93  943  943  ALA ALA B . n 
B 1 94  PHE 94  944  944  PHE PHE B . n 
B 1 95  GLU 95  945  945  GLU GLU B . n 
B 1 96  VAL 96  946  946  VAL VAL B . n 
B 1 97  SER 97  947  947  SER SER B . n 
B 1 98  GLU 98  948  948  GLU GLU B . n 
B 1 99  ASN 99  949  949  ASN ASN B . n 
B 1 100 GLY 100 950  950  GLY GLY B . n 
B 1 101 ASN 101 951  951  ASN ASN B . n 
B 1 102 LEU 102 952  952  LEU LEU B . n 
B 1 103 VAL 103 953  953  VAL VAL B . n 
B 1 104 VAL 104 954  954  VAL VAL B . n 
B 1 105 SER 105 955  955  SER SER B . n 
B 1 106 GLY 106 956  956  GLY GLY B . n 
B 1 107 LYS 107 957  957  LYS LYS B . n 
B 1 108 VAL 108 958  958  VAL VAL B . n 
B 1 109 TYR 109 959  959  TYR TYR B . n 
B 1 110 GLN 110 960  960  GLN GLN B . n 
B 1 111 TRP 111 961  961  TRP TRP B . n 
B 1 112 ASP 112 962  962  ASP ASP B . n 
B 1 113 ASP 113 963  963  ASP ASP B . n 
B 1 114 PRO 114 964  964  PRO PRO B . n 
B 1 115 ASP 115 965  965  ASP ASP B . n 
B 1 116 PRO 116 966  966  PRO PRO B . n 
B 1 117 ARG 117 967  967  ARG ARG B . n 
B 1 118 LEU 118 968  968  LEU LEU B . n 
B 1 119 PHE 119 969  969  PHE PHE B . n 
B 1 120 ASP 120 970  970  ASP ASP B . n 
B 1 121 HIS 121 971  971  HIS HIS B . n 
B 1 122 PRO 122 972  ?    ?   ?   B . n 
B 1 123 GLU 123 973  ?    ?   ?   B . n 
B 1 124 SER 124 974  ?    ?   ?   B . n 
B 1 125 PRO 125 975  ?    ?   ?   B . n 
B 1 126 THR 126 976  ?    ?   ?   B . n 
B 1 127 PRO 127 977  ?    ?   ?   B . n 
B 1 128 ASN 128 978  ?    ?   ?   B . n 
B 1 129 PRO 129 979  ?    ?   ?   B . n 
B 1 130 THR 130 980  ?    ?   ?   B . n 
B 1 131 GLU 131 981  ?    ?   ?   B . n 
B 1 132 PRO 132 982  ?    ?   ?   B . n 
B 1 133 LEU 133 983  983  LEU LEU B . n 
B 1 134 PHE 134 984  984  PHE PHE B . n 
B 1 135 LEU 135 985  985  LEU LEU B . n 
B 1 136 ALA 136 986  986  ALA ALA B . n 
B 1 137 GLN 137 987  987  GLN GLN B . n 
B 1 138 ALA 138 988  988  ALA ALA B . n 
B 1 139 GLU 139 989  989  GLU GLU B . n 
B 1 140 VAL 140 990  990  VAL VAL B . n 
B 1 141 TYR 141 991  991  TYR TYR B . n 
B 1 142 LYS 142 992  992  LYS LYS B . n 
B 1 143 GLU 143 993  993  GLU GLU B . n 
B 1 144 LEU 144 994  994  LEU LEU B . n 
B 1 145 ARG 145 995  995  ARG ARG B . n 
B 1 146 LEU 146 996  996  LEU LEU B . n 
B 1 147 ARG 147 997  997  ARG ARG B . n 
B 1 148 GLY 148 998  998  GLY GLY B . n 
B 1 149 TYR 149 999  999  TYR TYR B . n 
B 1 150 ASP 150 1000 1000 ASP ASP B . n 
B 1 151 TYR 151 1001 1001 TYR TYR B . n 
B 1 152 GLY 152 1002 1002 GLY GLY B . n 
B 1 153 PRO 153 1003 1003 PRO PRO B . n 
B 1 154 HIS 154 1004 1004 HIS HIS B . n 
B 1 155 PHE 155 1005 1005 PHE PHE B . n 
B 1 156 GLN 156 1006 1006 GLN GLN B . n 
B 1 157 GLY 157 1007 1007 GLY GLY B . n 
B 1 158 ILE 158 1008 1008 ILE ILE B . n 
B 1 159 LEU 159 1009 1009 LEU LEU B . n 
B 1 160 GLU 160 1010 1010 GLU GLU B . n 
B 1 161 ALA 161 1011 1011 ALA ALA B . n 
B 1 162 SER 162 1012 1012 SER SER B . n 
B 1 163 LEU 163 1013 1013 LEU LEU B . n 
B 1 164 GLU 164 1014 1014 GLU GLU B . n 
B 1 165 GLY 165 1015 1015 GLY GLY B . n 
B 1 166 ASP 166 1016 1016 ASP ASP B . n 
B 1 167 SER 167 1017 1017 SER SER B . n 
B 1 168 GLY 168 1018 1018 GLY GLY B . n 
B 1 169 ARG 169 1019 1019 ARG ARG B . n 
B 1 170 LEU 170 1020 1020 LEU LEU B . n 
B 1 171 LEU 171 1021 1021 LEU LEU B . n 
B 1 172 TRP 172 1022 1022 TRP TRP B . n 
B 1 173 LYS 173 1023 1023 LYS LYS B . n 
B 1 174 ASP 174 1024 1024 ASP ASP B . n 
B 1 175 ASN 175 1025 1025 ASN ASN B . n 
B 1 176 TRP 176 1026 1026 TRP TRP B . n 
B 1 177 VAL 177 1027 1027 VAL VAL B . n 
B 1 178 SER 178 1028 1028 SER SER B . n 
B 1 179 PHE 179 1029 1029 PHE PHE B . n 
B 1 180 MET 180 1030 1030 MET MET B . n 
B 1 181 ASP 181 1031 1031 ASP ASP B . n 
B 1 182 THR 182 1032 1032 THR THR B . n 
B 1 183 MET 183 1033 1033 MET MET B . n 
B 1 184 LEU 184 1034 1034 LEU LEU B . n 
B 1 185 GLN 185 1035 1035 GLN GLN B . n 
B 1 186 MET 186 1036 1036 MET MET B . n 
B 1 187 SER 187 1037 1037 SER SER B . n 
B 1 188 ILE 188 1038 1038 ILE ILE B . n 
B 1 189 LEU 189 1039 1039 LEU LEU B . n 
B 1 190 GLY 190 1040 1040 GLY GLY B . n 
B 1 191 SER 191 1041 1041 SER SER B . n 
B 1 192 ALA 192 1042 1042 ALA ALA B . n 
B 1 193 LYS 193 1043 1043 LYS LYS B . n 
B 1 194 HIS 194 1044 1044 HIS HIS B . n 
B 1 195 GLY 195 1045 1045 GLY GLY B . n 
B 1 196 LEU 196 1046 1046 LEU LEU B . n 
B 1 197 TYR 197 1047 1047 TYR TYR B . n 
B 1 198 LEU 198 1048 1048 LEU LEU B . n 
B 1 199 PRO 199 1049 1049 PRO PRO B . n 
B 1 200 THR 200 1050 1050 THR THR B . n 
B 1 201 ARG 201 1051 1051 ARG ARG B . n 
B 1 202 VAL 202 1052 1052 VAL VAL B . n 
B 1 203 THR 203 1053 1053 THR THR B . n 
B 1 204 ALA 204 1054 1054 ALA ALA B . n 
B 1 205 ILE 205 1055 1055 ILE ILE B . n 
B 1 206 HIS 206 1056 1056 HIS HIS B . n 
B 1 207 ILE 207 1057 1057 ILE ILE B . n 
B 1 208 ASP 208 1058 1058 ASP ASP B . n 
B 1 209 PRO 209 1059 1059 PRO PRO B . n 
B 1 210 ALA 210 1060 1060 ALA ALA B . n 
B 1 211 THR 211 1061 1061 THR THR B . n 
B 1 212 HIS 212 1062 1062 HIS HIS B . n 
B 1 213 ARG 213 1063 1063 ARG ARG B . n 
B 1 214 GLN 214 1064 1064 GLN GLN B . n 
B 1 215 LYS 215 1065 1065 LYS LYS B . n 
B 1 216 LEU 216 1066 1066 LEU LEU B . n 
B 1 217 TYR 217 1067 1067 TYR TYR B . n 
B 1 218 THR 218 1068 1068 THR THR B . n 
B 1 219 LEU 219 1069 1069 LEU LEU B . n 
B 1 220 GLN 220 1070 1070 GLN GLN B . n 
B 1 221 ASP 221 1071 1071 ASP ASP B . n 
B 1 222 LYS 222 1072 1072 LYS LYS B . n 
B 1 223 ALA 223 1073 1073 ALA ALA B . n 
B 1 224 GLN 224 1074 1074 GLN GLN B . n 
B 1 225 VAL 225 1075 1075 VAL VAL B . n 
B 1 226 ALA 226 1076 1076 ALA ALA B . n 
B 1 227 ASP 227 1077 1077 ASP ASP B . n 
B 1 228 VAL 228 1078 1078 VAL VAL B . n 
B 1 229 VAL 229 1079 1079 VAL VAL B . n 
B 1 230 VAL 230 1080 1080 VAL VAL B . n 
B 1 231 SER 231 1081 1081 SER SER B . n 
B 1 232 ARG 232 1082 1082 ARG ARG B . n 
B 1 233 TRP 233 1083 1083 TRP TRP B . n 
B 1 234 LEU 234 1084 1084 LEU LEU B . n 
B 1 235 ARG 235 1085 1085 ARG ARG B . n 
B 1 236 VAL 236 1086 1086 VAL VAL B . n 
B 1 237 THR 237 1087 1087 THR THR B . n 
B 1 238 VAL 238 1088 1088 VAL VAL B . n 
B 1 239 ALA 239 1089 1089 ALA ALA B . n 
B 1 240 GLY 240 1090 1090 GLY GLY B . n 
B 1 241 GLY 241 1091 1091 GLY GLY B . n 
B 1 242 VAL 242 1092 1092 VAL VAL B . n 
B 1 243 HIS 243 1093 1093 HIS HIS B . n 
B 1 244 ILE 244 1094 1094 ILE ILE B . n 
B 1 245 SER 245 1095 1095 SER SER B . n 
B 1 246 GLY 246 1096 1096 GLY GLY B . n 
B 1 247 LEU 247 1097 1097 LEU LEU B . n 
B 1 248 HIS 248 1098 1098 HIS HIS B . n 
B 1 249 THR 249 1099 1099 THR THR B . n 
B 1 250 GLU 250 1100 1100 GLU GLU B . n 
B 1 251 SER 251 1101 1101 SER SER B . n 
B 1 252 ALA 252 1102 1102 ALA ALA B . n 
C 1 1   SER 1   -7   -7   SER SER C . n 
C 1 2   GLU 2   -6   -6   GLU GLU C . n 
C 1 3   ASN 3   -5   -5   ASN ASN C . n 
C 1 4   LEU 4   -4   -4   LEU LEU C . n 
C 1 5   TYR 5   -3   -3   TYR TYR C . n 
C 1 6   PHE 6   -2   -2   PHE PHE C . n 
C 1 7   GLN 7   -1   -1   GLN GLN C . n 
C 1 8   SER 8   858  858  SER SER C . n 
C 1 9   ALA 9   859  859  ALA ALA C . n 
C 1 10  ALA 10  860  860  ALA ALA C . n 
C 1 11  ILE 11  861  861  ILE ILE C . n 
C 1 12  TYR 12  862  862  TYR TYR C . n 
C 1 13  ASN 13  863  863  ASN ASN C . n 
C 1 14  ILE 14  864  864  ILE ILE C . n 
C 1 15  ASP 15  865  865  ASP ASP C . n 
C 1 16  THR 16  866  866  THR THR C . n 
C 1 17  SER 17  867  867  SER SER C . n 
C 1 18  SER 18  868  868  SER SER C . n 
C 1 19  GLU 19  869  869  GLU GLU C . n 
C 1 20  SER 20  870  870  SER SER C . n 
C 1 21  PRO 21  871  871  PRO PRO C . n 
C 1 22  ASP 22  872  872  ASP ASP C . n 
C 1 23  HIS 23  873  873  HIS HIS C . n 
C 1 24  TYR 24  874  874  TYR TYR C . n 
C 1 25  LEU 25  875  875  LEU LEU C . n 
C 1 26  VAL 26  876  876  VAL VAL C . n 
C 1 27  ASP 27  877  877  ASP ASP C . n 
C 1 28  HIS 28  878  878  HIS HIS C . n 
C 1 29  THR 29  879  879  THR THR C . n 
C 1 30  LEU 30  880  880  LEU LEU C . n 
C 1 31  ASP 31  881  881  ASP ASP C . n 
C 1 32  GLY 32  882  882  GLY GLY C . n 
C 1 33  ARG 33  883  883  ARG ARG C . n 
C 1 34  VAL 34  884  884  VAL VAL C . n 
C 1 35  LEU 35  885  885  LEU LEU C . n 
C 1 36  PHE 36  886  886  PHE PHE C . n 
C 1 37  PRO 37  887  887  PRO PRO C . n 
C 1 38  ALA 38  888  888  ALA ALA C . n 
C 1 39  THR 39  889  889  THR THR C . n 
C 1 40  GLY 40  890  890  GLY GLY C . n 
C 1 41  TYR 41  891  891  TYR TYR C . n 
C 1 42  LEU 42  892  892  LEU LEU C . n 
C 1 43  SER 43  893  893  SER SER C . n 
C 1 44  ILE 44  894  894  ILE ILE C . n 
C 1 45  VAL 45  895  895  VAL VAL C . n 
C 1 46  TRP 46  896  896  TRP TRP C . n 
C 1 47  LYS 47  897  897  LYS LYS C . n 
C 1 48  THR 48  898  898  THR THR C . n 
C 1 49  LEU 49  899  899  LEU LEU C . n 
C 1 50  ALA 50  900  900  ALA ALA C . n 
C 1 51  ARG 51  901  901  ARG ARG C . n 
C 1 52  ALA 52  902  902  ALA ALA C . n 
C 1 53  LEU 53  903  903  LEU LEU C . n 
C 1 54  GLY 54  904  904  GLY GLY C . n 
C 1 55  LEU 55  905  905  LEU LEU C . n 
C 1 56  GLY 56  906  906  GLY GLY C . n 
C 1 57  VAL 57  907  907  VAL VAL C . n 
C 1 58  GLU 58  908  908  GLU GLU C . n 
C 1 59  GLN 59  909  909  GLN GLN C . n 
C 1 60  LEU 60  910  910  LEU LEU C . n 
C 1 61  PRO 61  911  911  PRO PRO C . n 
C 1 62  VAL 62  912  912  VAL VAL C . n 
C 1 63  VAL 63  913  913  VAL VAL C . n 
C 1 64  PHE 64  914  914  PHE PHE C . n 
C 1 65  GLU 65  915  915  GLU GLU C . n 
C 1 66  ASP 66  916  916  ASP ASP C . n 
C 1 67  VAL 67  917  917  VAL VAL C . n 
C 1 68  VAL 68  918  918  VAL VAL C . n 
C 1 69  LEU 69  919  919  LEU LEU C . n 
C 1 70  HIS 70  920  920  HIS HIS C . n 
C 1 71  GLN 71  921  921  GLN GLN C . n 
C 1 72  ALA 72  922  922  ALA ALA C . n 
C 1 73  THR 73  923  923  THR THR C . n 
C 1 74  ILE 74  924  924  ILE ILE C . n 
C 1 75  LEU 75  925  925  LEU LEU C . n 
C 1 76  PRO 76  926  926  PRO PRO C . n 
C 1 77  LYS 77  927  927  LYS LYS C . n 
C 1 78  THR 78  928  928  THR THR C . n 
C 1 79  GLY 79  929  929  GLY GLY C . n 
C 1 80  THR 80  930  930  THR THR C . n 
C 1 81  VAL 81  931  931  VAL VAL C . n 
C 1 82  SER 82  932  932  SER SER C . n 
C 1 83  LEU 83  933  933  LEU LEU C . n 
C 1 84  GLU 84  934  934  GLU GLU C . n 
C 1 85  VAL 85  935  935  VAL VAL C . n 
C 1 86  ARG 86  936  936  ARG ARG C . n 
C 1 87  LEU 87  937  937  LEU LEU C . n 
C 1 88  LEU 88  938  938  LEU LEU C . n 
C 1 89  GLU 89  939  939  GLU GLU C . n 
C 1 90  ALA 90  940  940  ALA ALA C . n 
C 1 91  SER 91  941  941  SER SER C . n 
C 1 92  ARG 92  942  942  ARG ARG C . n 
C 1 93  ALA 93  943  943  ALA ALA C . n 
C 1 94  PHE 94  944  944  PHE PHE C . n 
C 1 95  GLU 95  945  945  GLU GLU C . n 
C 1 96  VAL 96  946  946  VAL VAL C . n 
C 1 97  SER 97  947  947  SER SER C . n 
C 1 98  GLU 98  948  948  GLU GLU C . n 
C 1 99  ASN 99  949  949  ASN ASN C . n 
C 1 100 GLY 100 950  950  GLY GLY C . n 
C 1 101 ASN 101 951  951  ASN ASN C . n 
C 1 102 LEU 102 952  952  LEU LEU C . n 
C 1 103 VAL 103 953  953  VAL VAL C . n 
C 1 104 VAL 104 954  954  VAL VAL C . n 
C 1 105 SER 105 955  955  SER SER C . n 
C 1 106 GLY 106 956  956  GLY GLY C . n 
C 1 107 LYS 107 957  957  LYS LYS C . n 
C 1 108 VAL 108 958  958  VAL VAL C . n 
C 1 109 TYR 109 959  959  TYR TYR C . n 
C 1 110 GLN 110 960  960  GLN GLN C . n 
C 1 111 TRP 111 961  961  TRP TRP C . n 
C 1 112 ASP 112 962  962  ASP ASP C . n 
C 1 113 ASP 113 963  963  ASP ASP C . n 
C 1 114 PRO 114 964  964  PRO PRO C . n 
C 1 115 ASP 115 965  965  ASP ASP C . n 
C 1 116 PRO 116 966  966  PRO PRO C . n 
C 1 117 ARG 117 967  967  ARG ARG C . n 
C 1 118 LEU 118 968  968  LEU LEU C . n 
C 1 119 PHE 119 969  969  PHE PHE C . n 
C 1 120 ASP 120 970  970  ASP ASP C . n 
C 1 121 HIS 121 971  971  HIS HIS C . n 
C 1 122 PRO 122 972  972  PRO PRO C . n 
C 1 123 GLU 123 973  973  GLU GLU C . n 
C 1 124 SER 124 974  974  SER SER C . n 
C 1 125 PRO 125 975  975  PRO PRO C . n 
C 1 126 THR 126 976  976  THR THR C . n 
C 1 127 PRO 127 977  ?    ?   ?   C . n 
C 1 128 ASN 128 978  ?    ?   ?   C . n 
C 1 129 PRO 129 979  ?    ?   ?   C . n 
C 1 130 THR 130 980  ?    ?   ?   C . n 
C 1 131 GLU 131 981  ?    ?   ?   C . n 
C 1 132 PRO 132 982  ?    ?   ?   C . n 
C 1 133 LEU 133 983  ?    ?   ?   C . n 
C 1 134 PHE 134 984  984  PHE PHE C . n 
C 1 135 LEU 135 985  985  LEU LEU C . n 
C 1 136 ALA 136 986  986  ALA ALA C . n 
C 1 137 GLN 137 987  987  GLN GLN C . n 
C 1 138 ALA 138 988  988  ALA ALA C . n 
C 1 139 GLU 139 989  989  GLU GLU C . n 
C 1 140 VAL 140 990  990  VAL VAL C . n 
C 1 141 TYR 141 991  991  TYR TYR C . n 
C 1 142 LYS 142 992  992  LYS LYS C . n 
C 1 143 GLU 143 993  993  GLU GLU C . n 
C 1 144 LEU 144 994  994  LEU LEU C . n 
C 1 145 ARG 145 995  995  ARG ARG C . n 
C 1 146 LEU 146 996  996  LEU LEU C . n 
C 1 147 ARG 147 997  997  ARG ARG C . n 
C 1 148 GLY 148 998  998  GLY GLY C . n 
C 1 149 TYR 149 999  999  TYR TYR C . n 
C 1 150 ASP 150 1000 1000 ASP ASP C . n 
C 1 151 TYR 151 1001 1001 TYR TYR C . n 
C 1 152 GLY 152 1002 1002 GLY GLY C . n 
C 1 153 PRO 153 1003 1003 PRO PRO C . n 
C 1 154 HIS 154 1004 1004 HIS HIS C . n 
C 1 155 PHE 155 1005 1005 PHE PHE C . n 
C 1 156 GLN 156 1006 1006 GLN GLN C . n 
C 1 157 GLY 157 1007 1007 GLY GLY C . n 
C 1 158 ILE 158 1008 1008 ILE ILE C . n 
C 1 159 LEU 159 1009 1009 LEU LEU C . n 
C 1 160 GLU 160 1010 1010 GLU GLU C . n 
C 1 161 ALA 161 1011 1011 ALA ALA C . n 
C 1 162 SER 162 1012 1012 SER SER C . n 
C 1 163 LEU 163 1013 1013 LEU LEU C . n 
C 1 164 GLU 164 1014 1014 GLU GLU C . n 
C 1 165 GLY 165 1015 1015 GLY GLY C . n 
C 1 166 ASP 166 1016 1016 ASP ASP C . n 
C 1 167 SER 167 1017 1017 SER SER C . n 
C 1 168 GLY 168 1018 1018 GLY GLY C . n 
C 1 169 ARG 169 1019 1019 ARG ARG C . n 
C 1 170 LEU 170 1020 1020 LEU LEU C . n 
C 1 171 LEU 171 1021 1021 LEU LEU C . n 
C 1 172 TRP 172 1022 1022 TRP TRP C . n 
C 1 173 LYS 173 1023 1023 LYS LYS C . n 
C 1 174 ASP 174 1024 1024 ASP ASP C . n 
C 1 175 ASN 175 1025 1025 ASN ASN C . n 
C 1 176 TRP 176 1026 1026 TRP TRP C . n 
C 1 177 VAL 177 1027 1027 VAL VAL C . n 
C 1 178 SER 178 1028 1028 SER SER C . n 
C 1 179 PHE 179 1029 1029 PHE PHE C . n 
C 1 180 MET 180 1030 1030 MET MET C . n 
C 1 181 ASP 181 1031 1031 ASP ASP C . n 
C 1 182 THR 182 1032 1032 THR THR C . n 
C 1 183 MET 183 1033 1033 MET MET C . n 
C 1 184 LEU 184 1034 1034 LEU LEU C . n 
C 1 185 GLN 185 1035 1035 GLN GLN C . n 
C 1 186 MET 186 1036 1036 MET MET C . n 
C 1 187 SER 187 1037 1037 SER SER C . n 
C 1 188 ILE 188 1038 1038 ILE ILE C . n 
C 1 189 LEU 189 1039 1039 LEU LEU C . n 
C 1 190 GLY 190 1040 1040 GLY GLY C . n 
C 1 191 SER 191 1041 1041 SER SER C . n 
C 1 192 ALA 192 1042 1042 ALA ALA C . n 
C 1 193 LYS 193 1043 1043 LYS LYS C . n 
C 1 194 HIS 194 1044 1044 HIS HIS C . n 
C 1 195 GLY 195 1045 1045 GLY GLY C . n 
C 1 196 LEU 196 1046 1046 LEU LEU C . n 
C 1 197 TYR 197 1047 1047 TYR TYR C . n 
C 1 198 LEU 198 1048 1048 LEU LEU C . n 
C 1 199 PRO 199 1049 1049 PRO PRO C . n 
C 1 200 THR 200 1050 1050 THR THR C . n 
C 1 201 ARG 201 1051 1051 ARG ARG C . n 
C 1 202 VAL 202 1052 1052 VAL VAL C . n 
C 1 203 THR 203 1053 1053 THR THR C . n 
C 1 204 ALA 204 1054 1054 ALA ALA C . n 
C 1 205 ILE 205 1055 1055 ILE ILE C . n 
C 1 206 HIS 206 1056 1056 HIS HIS C . n 
C 1 207 ILE 207 1057 1057 ILE ILE C . n 
C 1 208 ASP 208 1058 1058 ASP ASP C . n 
C 1 209 PRO 209 1059 1059 PRO PRO C . n 
C 1 210 ALA 210 1060 1060 ALA ALA C . n 
C 1 211 THR 211 1061 1061 THR THR C . n 
C 1 212 HIS 212 1062 1062 HIS HIS C . n 
C 1 213 ARG 213 1063 1063 ARG ARG C . n 
C 1 214 GLN 214 1064 1064 GLN GLN C . n 
C 1 215 LYS 215 1065 1065 LYS LYS C . n 
C 1 216 LEU 216 1066 1066 LEU LEU C . n 
C 1 217 TYR 217 1067 1067 TYR TYR C . n 
C 1 218 THR 218 1068 1068 THR THR C . n 
C 1 219 LEU 219 1069 1069 LEU LEU C . n 
C 1 220 GLN 220 1070 1070 GLN GLN C . n 
C 1 221 ASP 221 1071 1071 ASP ASP C . n 
C 1 222 LYS 222 1072 1072 LYS LYS C . n 
C 1 223 ALA 223 1073 1073 ALA ALA C . n 
C 1 224 GLN 224 1074 1074 GLN GLN C . n 
C 1 225 VAL 225 1075 1075 VAL VAL C . n 
C 1 226 ALA 226 1076 1076 ALA ALA C . n 
C 1 227 ASP 227 1077 1077 ASP ASP C . n 
C 1 228 VAL 228 1078 1078 VAL VAL C . n 
C 1 229 VAL 229 1079 1079 VAL VAL C . n 
C 1 230 VAL 230 1080 1080 VAL VAL C . n 
C 1 231 SER 231 1081 1081 SER SER C . n 
C 1 232 ARG 232 1082 1082 ARG ARG C . n 
C 1 233 TRP 233 1083 1083 TRP TRP C . n 
C 1 234 LEU 234 1084 1084 LEU LEU C . n 
C 1 235 ARG 235 1085 1085 ARG ARG C . n 
C 1 236 VAL 236 1086 1086 VAL VAL C . n 
C 1 237 THR 237 1087 1087 THR THR C . n 
C 1 238 VAL 238 1088 1088 VAL VAL C . n 
C 1 239 ALA 239 1089 1089 ALA ALA C . n 
C 1 240 GLY 240 1090 1090 GLY GLY C . n 
C 1 241 GLY 241 1091 1091 GLY GLY C . n 
C 1 242 VAL 242 1092 1092 VAL VAL C . n 
C 1 243 HIS 243 1093 1093 HIS HIS C . n 
C 1 244 ILE 244 1094 1094 ILE ILE C . n 
C 1 245 SER 245 1095 1095 SER SER C . n 
C 1 246 GLY 246 1096 1096 GLY GLY C . n 
C 1 247 LEU 247 1097 1097 LEU LEU C . n 
C 1 248 HIS 248 1098 1098 HIS HIS C . n 
C 1 249 THR 249 1099 1099 THR THR C . n 
C 1 250 GLU 250 1100 1100 GLU GLU C . n 
C 1 251 SER 251 1101 1101 SER SER C . n 
C 1 252 ALA 252 1102 1102 ALA ALA C . n 
D 1 1   SER 1   -7   -7   SER SER D . n 
D 1 2   GLU 2   -6   -6   GLU GLU D . n 
D 1 3   ASN 3   -5   -5   ASN ASN D . n 
D 1 4   LEU 4   -4   -4   LEU LEU D . n 
D 1 5   TYR 5   -3   -3   TYR TYR D . n 
D 1 6   PHE 6   -2   -2   PHE PHE D . n 
D 1 7   GLN 7   -1   -1   GLN GLN D . n 
D 1 8   SER 8   858  858  SER SER D . n 
D 1 9   ALA 9   859  859  ALA ALA D . n 
D 1 10  ALA 10  860  860  ALA ALA D . n 
D 1 11  ILE 11  861  861  ILE ILE D . n 
D 1 12  TYR 12  862  862  TYR TYR D . n 
D 1 13  ASN 13  863  863  ASN ASN D . n 
D 1 14  ILE 14  864  864  ILE ILE D . n 
D 1 15  ASP 15  865  865  ASP ASP D . n 
D 1 16  THR 16  866  866  THR THR D . n 
D 1 17  SER 17  867  867  SER SER D . n 
D 1 18  SER 18  868  868  SER SER D . n 
D 1 19  GLU 19  869  869  GLU GLU D . n 
D 1 20  SER 20  870  870  SER SER D . n 
D 1 21  PRO 21  871  871  PRO PRO D . n 
D 1 22  ASP 22  872  872  ASP ASP D . n 
D 1 23  HIS 23  873  873  HIS HIS D . n 
D 1 24  TYR 24  874  874  TYR TYR D . n 
D 1 25  LEU 25  875  875  LEU LEU D . n 
D 1 26  VAL 26  876  876  VAL VAL D . n 
D 1 27  ASP 27  877  877  ASP ASP D . n 
D 1 28  HIS 28  878  878  HIS HIS D . n 
D 1 29  THR 29  879  879  THR THR D . n 
D 1 30  LEU 30  880  880  LEU LEU D . n 
D 1 31  ASP 31  881  881  ASP ASP D . n 
D 1 32  GLY 32  882  882  GLY GLY D . n 
D 1 33  ARG 33  883  883  ARG ARG D . n 
D 1 34  VAL 34  884  884  VAL VAL D . n 
D 1 35  LEU 35  885  885  LEU LEU D . n 
D 1 36  PHE 36  886  886  PHE PHE D . n 
D 1 37  PRO 37  887  887  PRO PRO D . n 
D 1 38  ALA 38  888  888  ALA ALA D . n 
D 1 39  THR 39  889  889  THR THR D . n 
D 1 40  GLY 40  890  890  GLY GLY D . n 
D 1 41  TYR 41  891  891  TYR TYR D . n 
D 1 42  LEU 42  892  892  LEU LEU D . n 
D 1 43  SER 43  893  893  SER SER D . n 
D 1 44  ILE 44  894  894  ILE ILE D . n 
D 1 45  VAL 45  895  895  VAL VAL D . n 
D 1 46  TRP 46  896  896  TRP TRP D . n 
D 1 47  LYS 47  897  897  LYS LYS D . n 
D 1 48  THR 48  898  898  THR THR D . n 
D 1 49  LEU 49  899  899  LEU LEU D . n 
D 1 50  ALA 50  900  900  ALA ALA D . n 
D 1 51  ARG 51  901  901  ARG ARG D . n 
D 1 52  ALA 52  902  902  ALA ALA D . n 
D 1 53  LEU 53  903  903  LEU LEU D . n 
D 1 54  GLY 54  904  904  GLY GLY D . n 
D 1 55  LEU 55  905  905  LEU LEU D . n 
D 1 56  GLY 56  906  906  GLY GLY D . n 
D 1 57  VAL 57  907  907  VAL VAL D . n 
D 1 58  GLU 58  908  908  GLU GLU D . n 
D 1 59  GLN 59  909  909  GLN GLN D . n 
D 1 60  LEU 60  910  910  LEU LEU D . n 
D 1 61  PRO 61  911  911  PRO PRO D . n 
D 1 62  VAL 62  912  912  VAL VAL D . n 
D 1 63  VAL 63  913  913  VAL VAL D . n 
D 1 64  PHE 64  914  914  PHE PHE D . n 
D 1 65  GLU 65  915  915  GLU GLU D . n 
D 1 66  ASP 66  916  916  ASP ASP D . n 
D 1 67  VAL 67  917  917  VAL VAL D . n 
D 1 68  VAL 68  918  918  VAL VAL D . n 
D 1 69  LEU 69  919  919  LEU LEU D . n 
D 1 70  HIS 70  920  920  HIS HIS D . n 
D 1 71  GLN 71  921  921  GLN GLN D . n 
D 1 72  ALA 72  922  922  ALA ALA D . n 
D 1 73  THR 73  923  923  THR THR D . n 
D 1 74  ILE 74  924  924  ILE ILE D . n 
D 1 75  LEU 75  925  925  LEU LEU D . n 
D 1 76  PRO 76  926  926  PRO PRO D . n 
D 1 77  LYS 77  927  927  LYS LYS D . n 
D 1 78  THR 78  928  928  THR THR D . n 
D 1 79  GLY 79  929  929  GLY GLY D . n 
D 1 80  THR 80  930  930  THR THR D . n 
D 1 81  VAL 81  931  931  VAL VAL D . n 
D 1 82  SER 82  932  932  SER SER D . n 
D 1 83  LEU 83  933  933  LEU LEU D . n 
D 1 84  GLU 84  934  934  GLU GLU D . n 
D 1 85  VAL 85  935  935  VAL VAL D . n 
D 1 86  ARG 86  936  936  ARG ARG D . n 
D 1 87  LEU 87  937  937  LEU LEU D . n 
D 1 88  LEU 88  938  938  LEU LEU D . n 
D 1 89  GLU 89  939  939  GLU GLU D . n 
D 1 90  ALA 90  940  940  ALA ALA D . n 
D 1 91  SER 91  941  941  SER SER D . n 
D 1 92  ARG 92  942  942  ARG ARG D . n 
D 1 93  ALA 93  943  943  ALA ALA D . n 
D 1 94  PHE 94  944  944  PHE PHE D . n 
D 1 95  GLU 95  945  945  GLU GLU D . n 
D 1 96  VAL 96  946  946  VAL VAL D . n 
D 1 97  SER 97  947  947  SER SER D . n 
D 1 98  GLU 98  948  948  GLU GLU D . n 
D 1 99  ASN 99  949  949  ASN ASN D . n 
D 1 100 GLY 100 950  950  GLY GLY D . n 
D 1 101 ASN 101 951  951  ASN ASN D . n 
D 1 102 LEU 102 952  952  LEU LEU D . n 
D 1 103 VAL 103 953  953  VAL VAL D . n 
D 1 104 VAL 104 954  954  VAL VAL D . n 
D 1 105 SER 105 955  955  SER SER D . n 
D 1 106 GLY 106 956  956  GLY GLY D . n 
D 1 107 LYS 107 957  957  LYS LYS D . n 
D 1 108 VAL 108 958  958  VAL VAL D . n 
D 1 109 TYR 109 959  959  TYR TYR D . n 
D 1 110 GLN 110 960  960  GLN GLN D . n 
D 1 111 TRP 111 961  961  TRP TRP D . n 
D 1 112 ASP 112 962  962  ASP ASP D . n 
D 1 113 ASP 113 963  963  ASP ASP D . n 
D 1 114 PRO 114 964  964  PRO PRO D . n 
D 1 115 ASP 115 965  965  ASP ASP D . n 
D 1 116 PRO 116 966  966  PRO PRO D . n 
D 1 117 ARG 117 967  967  ARG ARG D . n 
D 1 118 LEU 118 968  968  LEU LEU D . n 
D 1 119 PHE 119 969  969  PHE PHE D . n 
D 1 120 ASP 120 970  970  ASP ASP D . n 
D 1 121 HIS 121 971  971  HIS HIS D . n 
D 1 122 PRO 122 972  ?    ?   ?   D . n 
D 1 123 GLU 123 973  ?    ?   ?   D . n 
D 1 124 SER 124 974  ?    ?   ?   D . n 
D 1 125 PRO 125 975  ?    ?   ?   D . n 
D 1 126 THR 126 976  ?    ?   ?   D . n 
D 1 127 PRO 127 977  ?    ?   ?   D . n 
D 1 128 ASN 128 978  ?    ?   ?   D . n 
D 1 129 PRO 129 979  ?    ?   ?   D . n 
D 1 130 THR 130 980  ?    ?   ?   D . n 
D 1 131 GLU 131 981  ?    ?   ?   D . n 
D 1 132 PRO 132 982  ?    ?   ?   D . n 
D 1 133 LEU 133 983  ?    ?   ?   D . n 
D 1 134 PHE 134 984  984  PHE PHE D . n 
D 1 135 LEU 135 985  985  LEU LEU D . n 
D 1 136 ALA 136 986  986  ALA ALA D . n 
D 1 137 GLN 137 987  987  GLN GLN D . n 
D 1 138 ALA 138 988  988  ALA ALA D . n 
D 1 139 GLU 139 989  989  GLU GLU D . n 
D 1 140 VAL 140 990  990  VAL VAL D . n 
D 1 141 TYR 141 991  991  TYR TYR D . n 
D 1 142 LYS 142 992  992  LYS LYS D . n 
D 1 143 GLU 143 993  993  GLU GLU D . n 
D 1 144 LEU 144 994  994  LEU LEU D . n 
D 1 145 ARG 145 995  995  ARG ARG D . n 
D 1 146 LEU 146 996  996  LEU LEU D . n 
D 1 147 ARG 147 997  997  ARG ARG D . n 
D 1 148 GLY 148 998  998  GLY GLY D . n 
D 1 149 TYR 149 999  999  TYR TYR D . n 
D 1 150 ASP 150 1000 1000 ASP ASP D . n 
D 1 151 TYR 151 1001 1001 TYR TYR D . n 
D 1 152 GLY 152 1002 1002 GLY GLY D . n 
D 1 153 PRO 153 1003 1003 PRO PRO D . n 
D 1 154 HIS 154 1004 1004 HIS HIS D . n 
D 1 155 PHE 155 1005 1005 PHE PHE D . n 
D 1 156 GLN 156 1006 1006 GLN GLN D . n 
D 1 157 GLY 157 1007 1007 GLY GLY D . n 
D 1 158 ILE 158 1008 1008 ILE ILE D . n 
D 1 159 LEU 159 1009 1009 LEU LEU D . n 
D 1 160 GLU 160 1010 1010 GLU GLU D . n 
D 1 161 ALA 161 1011 1011 ALA ALA D . n 
D 1 162 SER 162 1012 1012 SER SER D . n 
D 1 163 LEU 163 1013 1013 LEU LEU D . n 
D 1 164 GLU 164 1014 1014 GLU GLU D . n 
D 1 165 GLY 165 1015 1015 GLY GLY D . n 
D 1 166 ASP 166 1016 1016 ASP ASP D . n 
D 1 167 SER 167 1017 1017 SER SER D . n 
D 1 168 GLY 168 1018 1018 GLY GLY D . n 
D 1 169 ARG 169 1019 1019 ARG ARG D . n 
D 1 170 LEU 170 1020 1020 LEU LEU D . n 
D 1 171 LEU 171 1021 1021 LEU LEU D . n 
D 1 172 TRP 172 1022 1022 TRP TRP D . n 
D 1 173 LYS 173 1023 1023 LYS LYS D . n 
D 1 174 ASP 174 1024 1024 ASP ASP D . n 
D 1 175 ASN 175 1025 1025 ASN ASN D . n 
D 1 176 TRP 176 1026 1026 TRP TRP D . n 
D 1 177 VAL 177 1027 1027 VAL VAL D . n 
D 1 178 SER 178 1028 1028 SER SER D . n 
D 1 179 PHE 179 1029 1029 PHE PHE D . n 
D 1 180 MET 180 1030 1030 MET MET D . n 
D 1 181 ASP 181 1031 1031 ASP ASP D . n 
D 1 182 THR 182 1032 1032 THR THR D . n 
D 1 183 MET 183 1033 1033 MET MET D . n 
D 1 184 LEU 184 1034 1034 LEU LEU D . n 
D 1 185 GLN 185 1035 1035 GLN GLN D . n 
D 1 186 MET 186 1036 1036 MET MET D . n 
D 1 187 SER 187 1037 1037 SER SER D . n 
D 1 188 ILE 188 1038 1038 ILE ILE D . n 
D 1 189 LEU 189 1039 1039 LEU LEU D . n 
D 1 190 GLY 190 1040 1040 GLY GLY D . n 
D 1 191 SER 191 1041 1041 SER SER D . n 
D 1 192 ALA 192 1042 1042 ALA ALA D . n 
D 1 193 LYS 193 1043 1043 LYS LYS D . n 
D 1 194 HIS 194 1044 1044 HIS HIS D . n 
D 1 195 GLY 195 1045 1045 GLY GLY D . n 
D 1 196 LEU 196 1046 1046 LEU LEU D . n 
D 1 197 TYR 197 1047 1047 TYR TYR D . n 
D 1 198 LEU 198 1048 1048 LEU LEU D . n 
D 1 199 PRO 199 1049 1049 PRO PRO D . n 
D 1 200 THR 200 1050 1050 THR THR D . n 
D 1 201 ARG 201 1051 1051 ARG ARG D . n 
D 1 202 VAL 202 1052 1052 VAL VAL D . n 
D 1 203 THR 203 1053 1053 THR THR D . n 
D 1 204 ALA 204 1054 1054 ALA ALA D . n 
D 1 205 ILE 205 1055 1055 ILE ILE D . n 
D 1 206 HIS 206 1056 1056 HIS HIS D . n 
D 1 207 ILE 207 1057 1057 ILE ILE D . n 
D 1 208 ASP 208 1058 1058 ASP ASP D . n 
D 1 209 PRO 209 1059 1059 PRO PRO D . n 
D 1 210 ALA 210 1060 1060 ALA ALA D . n 
D 1 211 THR 211 1061 1061 THR THR D . n 
D 1 212 HIS 212 1062 1062 HIS HIS D . n 
D 1 213 ARG 213 1063 1063 ARG ARG D . n 
D 1 214 GLN 214 1064 1064 GLN GLN D . n 
D 1 215 LYS 215 1065 1065 LYS LYS D . n 
D 1 216 LEU 216 1066 1066 LEU LEU D . n 
D 1 217 TYR 217 1067 1067 TYR TYR D . n 
D 1 218 THR 218 1068 1068 THR THR D . n 
D 1 219 LEU 219 1069 1069 LEU LEU D . n 
D 1 220 GLN 220 1070 1070 GLN GLN D . n 
D 1 221 ASP 221 1071 1071 ASP ASP D . n 
D 1 222 LYS 222 1072 1072 LYS LYS D . n 
D 1 223 ALA 223 1073 1073 ALA ALA D . n 
D 1 224 GLN 224 1074 1074 GLN GLN D . n 
D 1 225 VAL 225 1075 1075 VAL VAL D . n 
D 1 226 ALA 226 1076 1076 ALA ALA D . n 
D 1 227 ASP 227 1077 1077 ASP ASP D . n 
D 1 228 VAL 228 1078 1078 VAL VAL D . n 
D 1 229 VAL 229 1079 1079 VAL VAL D . n 
D 1 230 VAL 230 1080 1080 VAL VAL D . n 
D 1 231 SER 231 1081 1081 SER SER D . n 
D 1 232 ARG 232 1082 1082 ARG ARG D . n 
D 1 233 TRP 233 1083 1083 TRP TRP D . n 
D 1 234 LEU 234 1084 1084 LEU LEU D . n 
D 1 235 ARG 235 1085 1085 ARG ARG D . n 
D 1 236 VAL 236 1086 1086 VAL VAL D . n 
D 1 237 THR 237 1087 1087 THR THR D . n 
D 1 238 VAL 238 1088 1088 VAL VAL D . n 
D 1 239 ALA 239 1089 1089 ALA ALA D . n 
D 1 240 GLY 240 1090 1090 GLY GLY D . n 
D 1 241 GLY 241 1091 1091 GLY GLY D . n 
D 1 242 VAL 242 1092 1092 VAL VAL D . n 
D 1 243 HIS 243 1093 1093 HIS HIS D . n 
D 1 244 ILE 244 1094 1094 ILE ILE D . n 
D 1 245 SER 245 1095 1095 SER SER D . n 
D 1 246 GLY 246 1096 1096 GLY GLY D . n 
D 1 247 LEU 247 1097 1097 LEU LEU D . n 
D 1 248 HIS 248 1098 1098 HIS HIS D . n 
D 1 249 THR 249 1099 1099 THR THR D . n 
D 1 250 GLU 250 1100 1100 GLU GLU D . n 
D 1 251 SER 251 1101 1101 SER SER D . n 
D 1 252 ALA 252 1102 1102 ALA ALA D . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        IOD 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   IOD 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 2 IOD 1   2000 2000 IOD IOD A . 
F 2 IOD 1   2001 2001 IOD IOD A . 
G 2 IOD 1   2000 2000 IOD IOD B . 
H 2 IOD 1   2001 2001 IOD IOD B . 
I 2 IOD 1   2000 2000 IOD IOD C . 
J 2 IOD 1   2001 2001 IOD IOD C . 
K 2 IOD 1   2000 2000 IOD IOD D . 
L 3 HOH 1   2101 739  HOH HOH A . 
L 3 HOH 2   2102 331  HOH HOH A . 
L 3 HOH 3   2103 382  HOH HOH A . 
L 3 HOH 4   2104 656  HOH HOH A . 
L 3 HOH 5   2105 430  HOH HOH A . 
L 3 HOH 6   2106 233  HOH HOH A . 
L 3 HOH 7   2107 357  HOH HOH A . 
L 3 HOH 8   2108 468  HOH HOH A . 
L 3 HOH 9   2109 698  HOH HOH A . 
L 3 HOH 10  2110 323  HOH HOH A . 
L 3 HOH 11  2111 224  HOH HOH A . 
L 3 HOH 12  2112 431  HOH HOH A . 
L 3 HOH 13  2113 517  HOH HOH A . 
L 3 HOH 14  2114 428  HOH HOH A . 
L 3 HOH 15  2115 432  HOH HOH A . 
L 3 HOH 16  2116 116  HOH HOH A . 
L 3 HOH 17  2117 42   HOH HOH A . 
L 3 HOH 18  2118 213  HOH HOH A . 
L 3 HOH 19  2119 735  HOH HOH A . 
L 3 HOH 20  2120 326  HOH HOH A . 
L 3 HOH 21  2121 226  HOH HOH A . 
L 3 HOH 22  2122 138  HOH HOH A . 
L 3 HOH 23  2123 20   HOH HOH A . 
L 3 HOH 24  2124 308  HOH HOH A . 
L 3 HOH 25  2125 424  HOH HOH A . 
L 3 HOH 26  2126 128  HOH HOH A . 
L 3 HOH 27  2127 31   HOH HOH A . 
L 3 HOH 28  2128 231  HOH HOH A . 
L 3 HOH 29  2129 99   HOH HOH A . 
L 3 HOH 30  2130 61   HOH HOH A . 
L 3 HOH 31  2131 473  HOH HOH A . 
L 3 HOH 32  2132 36   HOH HOH A . 
L 3 HOH 33  2133 53   HOH HOH A . 
L 3 HOH 34  2134 392  HOH HOH A . 
L 3 HOH 35  2135 271  HOH HOH A . 
L 3 HOH 36  2136 131  HOH HOH A . 
L 3 HOH 37  2137 463  HOH HOH A . 
L 3 HOH 38  2138 639  HOH HOH A . 
L 3 HOH 39  2139 297  HOH HOH A . 
L 3 HOH 40  2140 229  HOH HOH A . 
L 3 HOH 41  2141 553  HOH HOH A . 
L 3 HOH 42  2142 54   HOH HOH A . 
L 3 HOH 43  2143 12   HOH HOH A . 
L 3 HOH 44  2144 22   HOH HOH A . 
L 3 HOH 45  2145 19   HOH HOH A . 
L 3 HOH 46  2146 490  HOH HOH A . 
L 3 HOH 47  2147 139  HOH HOH A . 
L 3 HOH 48  2148 506  HOH HOH A . 
L 3 HOH 49  2149 399  HOH HOH A . 
L 3 HOH 50  2150 67   HOH HOH A . 
L 3 HOH 51  2151 300  HOH HOH A . 
L 3 HOH 52  2152 9    HOH HOH A . 
L 3 HOH 53  2153 1    HOH HOH A . 
L 3 HOH 54  2154 127  HOH HOH A . 
L 3 HOH 55  2155 488  HOH HOH A . 
L 3 HOH 56  2156 288  HOH HOH A . 
L 3 HOH 57  2157 395  HOH HOH A . 
L 3 HOH 58  2158 427  HOH HOH A . 
L 3 HOH 59  2159 69   HOH HOH A . 
L 3 HOH 60  2160 736  HOH HOH A . 
L 3 HOH 61  2161 25   HOH HOH A . 
L 3 HOH 62  2162 150  HOH HOH A . 
L 3 HOH 63  2163 130  HOH HOH A . 
L 3 HOH 64  2164 200  HOH HOH A . 
L 3 HOH 65  2165 86   HOH HOH A . 
L 3 HOH 66  2166 259  HOH HOH A . 
L 3 HOH 67  2167 368  HOH HOH A . 
L 3 HOH 68  2168 596  HOH HOH A . 
L 3 HOH 69  2169 590  HOH HOH A . 
L 3 HOH 70  2170 342  HOH HOH A . 
L 3 HOH 71  2171 157  HOH HOH A . 
L 3 HOH 72  2172 356  HOH HOH A . 
L 3 HOH 73  2173 155  HOH HOH A . 
L 3 HOH 74  2174 525  HOH HOH A . 
L 3 HOH 75  2175 305  HOH HOH A . 
L 3 HOH 76  2176 201  HOH HOH A . 
L 3 HOH 77  2177 574  HOH HOH A . 
L 3 HOH 78  2178 181  HOH HOH A . 
L 3 HOH 79  2179 134  HOH HOH A . 
L 3 HOH 80  2180 169  HOH HOH A . 
L 3 HOH 81  2181 13   HOH HOH A . 
L 3 HOH 82  2182 409  HOH HOH A . 
L 3 HOH 83  2183 563  HOH HOH A . 
L 3 HOH 84  2184 363  HOH HOH A . 
L 3 HOH 85  2185 32   HOH HOH A . 
L 3 HOH 86  2186 294  HOH HOH A . 
L 3 HOH 87  2187 278  HOH HOH A . 
L 3 HOH 88  2188 437  HOH HOH A . 
L 3 HOH 89  2189 618  HOH HOH A . 
L 3 HOH 90  2190 55   HOH HOH A . 
L 3 HOH 91  2191 681  HOH HOH A . 
L 3 HOH 92  2192 257  HOH HOH A . 
L 3 HOH 93  2193 198  HOH HOH A . 
L 3 HOH 94  2194 752  HOH HOH A . 
L 3 HOH 95  2195 82   HOH HOH A . 
L 3 HOH 96  2196 744  HOH HOH A . 
L 3 HOH 97  2197 747  HOH HOH A . 
L 3 HOH 98  2198 154  HOH HOH A . 
L 3 HOH 99  2199 666  HOH HOH A . 
L 3 HOH 100 2200 435  HOH HOH A . 
L 3 HOH 101 2201 451  HOH HOH A . 
L 3 HOH 102 2202 511  HOH HOH A . 
L 3 HOH 103 2203 619  HOH HOH A . 
L 3 HOH 104 2204 745  HOH HOH A . 
L 3 HOH 105 2205 346  HOH HOH A . 
L 3 HOH 106 2206 661  HOH HOH A . 
L 3 HOH 107 2207 24   HOH HOH A . 
L 3 HOH 108 2208 349  HOH HOH A . 
L 3 HOH 109 2209 168  HOH HOH A . 
L 3 HOH 110 2210 412  HOH HOH A . 
L 3 HOH 111 2211 251  HOH HOH A . 
L 3 HOH 112 2212 436  HOH HOH A . 
L 3 HOH 113 2213 592  HOH HOH A . 
L 3 HOH 114 2214 221  HOH HOH A . 
L 3 HOH 115 2215 550  HOH HOH A . 
L 3 HOH 116 2216 291  HOH HOH A . 
L 3 HOH 117 2217 162  HOH HOH A . 
L 3 HOH 118 2218 236  HOH HOH A . 
L 3 HOH 119 2219 62   HOH HOH A . 
L 3 HOH 120 2220 429  HOH HOH A . 
L 3 HOH 121 2221 425  HOH HOH A . 
L 3 HOH 122 2222 359  HOH HOH A . 
L 3 HOH 123 2223 73   HOH HOH A . 
L 3 HOH 124 2224 84   HOH HOH A . 
L 3 HOH 125 2225 28   HOH HOH A . 
L 3 HOH 126 2226 565  HOH HOH A . 
L 3 HOH 127 2227 433  HOH HOH A . 
L 3 HOH 128 2228 741  HOH HOH A . 
L 3 HOH 129 2229 43   HOH HOH A . 
L 3 HOH 130 2230 505  HOH HOH A . 
L 3 HOH 131 2231 47   HOH HOH A . 
L 3 HOH 132 2232 580  HOH HOH A . 
L 3 HOH 133 2233 247  HOH HOH A . 
L 3 HOH 134 2234 411  HOH HOH A . 
L 3 HOH 135 2235 595  HOH HOH A . 
L 3 HOH 136 2236 749  HOH HOH A . 
L 3 HOH 137 2237 737  HOH HOH A . 
L 3 HOH 138 2238 380  HOH HOH A . 
L 3 HOH 139 2239 405  HOH HOH A . 
L 3 HOH 140 2240 625  HOH HOH A . 
L 3 HOH 141 2241 486  HOH HOH A . 
L 3 HOH 142 2242 683  HOH HOH A . 
L 3 HOH 143 2243 686  HOH HOH A . 
L 3 HOH 144 2244 648  HOH HOH A . 
L 3 HOH 145 2245 621  HOH HOH A . 
L 3 HOH 146 2246 746  HOH HOH A . 
L 3 HOH 147 2247 750  HOH HOH A . 
L 3 HOH 148 2248 707  HOH HOH A . 
L 3 HOH 149 2249 671  HOH HOH A . 
L 3 HOH 150 2250 523  HOH HOH A . 
L 3 HOH 151 2251 531  HOH HOH A . 
L 3 HOH 152 2252 594  HOH HOH A . 
L 3 HOH 153 2253 498  HOH HOH A . 
L 3 HOH 154 2254 332  HOH HOH A . 
L 3 HOH 155 2255 268  HOH HOH A . 
L 3 HOH 156 2256 587  HOH HOH A . 
L 3 HOH 157 2257 569  HOH HOH A . 
L 3 HOH 158 2258 599  HOH HOH A . 
L 3 HOH 159 2259 717  HOH HOH A . 
L 3 HOH 160 2260 177  HOH HOH A . 
L 3 HOH 161 2261 558  HOH HOH A . 
L 3 HOH 162 2262 742  HOH HOH A . 
L 3 HOH 163 2263 324  HOH HOH A . 
L 3 HOH 164 2264 222  HOH HOH A . 
L 3 HOH 165 2265 439  HOH HOH A . 
L 3 HOH 166 2266 597  HOH HOH A . 
L 3 HOH 167 2267 593  HOH HOH A . 
L 3 HOH 168 2268 676  HOH HOH A . 
L 3 HOH 169 2269 524  HOH HOH A . 
L 3 HOH 170 2270 591  HOH HOH A . 
L 3 HOH 171 2271 659  HOH HOH A . 
L 3 HOH 172 2272 180  HOH HOH A . 
L 3 HOH 173 2273 398  HOH HOH A . 
L 3 HOH 174 2274 534  HOH HOH A . 
L 3 HOH 175 2275 434  HOH HOH A . 
L 3 HOH 176 2276 532  HOH HOH A . 
L 3 HOH 177 2277 241  HOH HOH A . 
L 3 HOH 178 2278 367  HOH HOH A . 
L 3 HOH 179 2279 196  HOH HOH A . 
L 3 HOH 180 2280 650  HOH HOH A . 
L 3 HOH 181 2281 151  HOH HOH A . 
L 3 HOH 182 2282 358  HOH HOH A . 
L 3 HOH 183 2283 373  HOH HOH A . 
L 3 HOH 184 2284 655  HOH HOH A . 
L 3 HOH 185 2285 420  HOH HOH A . 
L 3 HOH 186 2286 562  HOH HOH A . 
L 3 HOH 187 2287 309  HOH HOH A . 
L 3 HOH 188 2288 120  HOH HOH A . 
L 3 HOH 189 2289 328  HOH HOH A . 
L 3 HOH 190 2290 426  HOH HOH A . 
L 3 HOH 191 2291 658  HOH HOH A . 
L 3 HOH 192 2292 712  HOH HOH A . 
L 3 HOH 193 2293 386  HOH HOH A . 
L 3 HOH 194 2294 410  HOH HOH A . 
L 3 HOH 195 2295 720  HOH HOH A . 
L 3 HOH 196 2296 322  HOH HOH A . 
M 3 HOH 1   2101 447  HOH HOH B . 
M 3 HOH 2   2102 41   HOH HOH B . 
M 3 HOH 3   2103 450  HOH HOH B . 
M 3 HOH 4   2104 250  HOH HOH B . 
M 3 HOH 5   2105 448  HOH HOH B . 
M 3 HOH 6   2106 126  HOH HOH B . 
M 3 HOH 7   2107 552  HOH HOH B . 
M 3 HOH 8   2108 644  HOH HOH B . 
M 3 HOH 9   2109 441  HOH HOH B . 
M 3 HOH 10  2110 604  HOH HOH B . 
M 3 HOH 11  2111 758  HOH HOH B . 
M 3 HOH 12  2112 533  HOH HOH B . 
M 3 HOH 13  2113 195  HOH HOH B . 
M 3 HOH 14  2114 479  HOH HOH B . 
M 3 HOH 15  2115 156  HOH HOH B . 
M 3 HOH 16  2116 763  HOH HOH B . 
M 3 HOH 17  2117 220  HOH HOH B . 
M 3 HOH 18  2118 777  HOH HOH B . 
M 3 HOH 19  2119 469  HOH HOH B . 
M 3 HOH 20  2120 449  HOH HOH B . 
M 3 HOH 21  2121 90   HOH HOH B . 
M 3 HOH 22  2122 189  HOH HOH B . 
M 3 HOH 23  2123 108  HOH HOH B . 
M 3 HOH 24  2124 50   HOH HOH B . 
M 3 HOH 25  2125 81   HOH HOH B . 
M 3 HOH 26  2126 26   HOH HOH B . 
M 3 HOH 27  2127 264  HOH HOH B . 
M 3 HOH 28  2128 10   HOH HOH B . 
M 3 HOH 29  2129 603  HOH HOH B . 
M 3 HOH 30  2130 262  HOH HOH B . 
M 3 HOH 31  2131 136  HOH HOH B . 
M 3 HOH 32  2132 92   HOH HOH B . 
M 3 HOH 33  2133 6    HOH HOH B . 
M 3 HOH 34  2134 504  HOH HOH B . 
M 3 HOH 35  2135 600  HOH HOH B . 
M 3 HOH 36  2136 492  HOH HOH B . 
M 3 HOH 37  2137 188  HOH HOH B . 
M 3 HOH 38  2138 215  HOH HOH B . 
M 3 HOH 39  2139 125  HOH HOH B . 
M 3 HOH 40  2140 443  HOH HOH B . 
M 3 HOH 41  2141 49   HOH HOH B . 
M 3 HOH 42  2142 403  HOH HOH B . 
M 3 HOH 43  2143 768  HOH HOH B . 
M 3 HOH 44  2144 101  HOH HOH B . 
M 3 HOH 45  2145 217  HOH HOH B . 
M 3 HOH 46  2146 2    HOH HOH B . 
M 3 HOH 47  2147 567  HOH HOH B . 
M 3 HOH 48  2148 489  HOH HOH B . 
M 3 HOH 49  2149 71   HOH HOH B . 
M 3 HOH 50  2150 393  HOH HOH B . 
M 3 HOH 51  2151 235  HOH HOH B . 
M 3 HOH 52  2152 665  HOH HOH B . 
M 3 HOH 53  2153 204  HOH HOH B . 
M 3 HOH 54  2154 632  HOH HOH B . 
M 3 HOH 55  2155 711  HOH HOH B . 
M 3 HOH 56  2156 415  HOH HOH B . 
M 3 HOH 57  2157 252  HOH HOH B . 
M 3 HOH 58  2158 110  HOH HOH B . 
M 3 HOH 59  2159 100  HOH HOH B . 
M 3 HOH 60  2160 11   HOH HOH B . 
M 3 HOH 61  2161 132  HOH HOH B . 
M 3 HOH 62  2162 21   HOH HOH B . 
M 3 HOH 63  2163 170  HOH HOH B . 
M 3 HOH 64  2164 528  HOH HOH B . 
M 3 HOH 65  2165 281  HOH HOH B . 
M 3 HOH 66  2166 240  HOH HOH B . 
M 3 HOH 67  2167 422  HOH HOH B . 
M 3 HOH 68  2168 312  HOH HOH B . 
M 3 HOH 69  2169 87   HOH HOH B . 
M 3 HOH 70  2170 228  HOH HOH B . 
M 3 HOH 71  2171 478  HOH HOH B . 
M 3 HOH 72  2172 275  HOH HOH B . 
M 3 HOH 73  2173 40   HOH HOH B . 
M 3 HOH 74  2174 66   HOH HOH B . 
M 3 HOH 75  2175 105  HOH HOH B . 
M 3 HOH 76  2176 727  HOH HOH B . 
M 3 HOH 77  2177 765  HOH HOH B . 
M 3 HOH 78  2178 17   HOH HOH B . 
M 3 HOH 79  2179 33   HOH HOH B . 
M 3 HOH 80  2180 547  HOH HOH B . 
M 3 HOH 81  2181 493  HOH HOH B . 
M 3 HOH 82  2182 497  HOH HOH B . 
M 3 HOH 83  2183 70   HOH HOH B . 
M 3 HOH 84  2184 321  HOH HOH B . 
M 3 HOH 85  2185 548  HOH HOH B . 
M 3 HOH 86  2186 261  HOH HOH B . 
M 3 HOH 87  2187 414  HOH HOH B . 
M 3 HOH 88  2188 289  HOH HOH B . 
M 3 HOH 89  2189 521  HOH HOH B . 
M 3 HOH 90  2190 290  HOH HOH B . 
M 3 HOH 91  2191 149  HOH HOH B . 
M 3 HOH 92  2192 700  HOH HOH B . 
M 3 HOH 93  2193 626  HOH HOH B . 
M 3 HOH 94  2194 91   HOH HOH B . 
M 3 HOH 95  2195 104  HOH HOH B . 
M 3 HOH 96  2196 748  HOH HOH B . 
M 3 HOH 97  2197 754  HOH HOH B . 
M 3 HOH 98  2198 445  HOH HOH B . 
M 3 HOH 99  2199 234  HOH HOH B . 
M 3 HOH 100 2200 388  HOH HOH B . 
M 3 HOH 101 2201 96   HOH HOH B . 
M 3 HOH 102 2202 586  HOH HOH B . 
M 3 HOH 103 2203 519  HOH HOH B . 
M 3 HOH 104 2204 651  HOH HOH B . 
M 3 HOH 105 2205 654  HOH HOH B . 
M 3 HOH 106 2206 774  HOH HOH B . 
M 3 HOH 107 2207 137  HOH HOH B . 
M 3 HOH 108 2208 283  HOH HOH B . 
M 3 HOH 109 2209 371  HOH HOH B . 
M 3 HOH 110 2210 729  HOH HOH B . 
M 3 HOH 111 2211 35   HOH HOH B . 
M 3 HOH 112 2212 687  HOH HOH B . 
M 3 HOH 113 2213 148  HOH HOH B . 
M 3 HOH 114 2214 780  HOH HOH B . 
M 3 HOH 115 2215 93   HOH HOH B . 
M 3 HOH 116 2216 396  HOH HOH B . 
M 3 HOH 117 2217 76   HOH HOH B . 
M 3 HOH 118 2218 260  HOH HOH B . 
M 3 HOH 119 2219 440  HOH HOH B . 
M 3 HOH 120 2220 690  HOH HOH B . 
M 3 HOH 121 2221 216  HOH HOH B . 
M 3 HOH 122 2222 208  HOH HOH B . 
M 3 HOH 123 2223 153  HOH HOH B . 
M 3 HOH 124 2224 365  HOH HOH B . 
M 3 HOH 125 2225 743  HOH HOH B . 
M 3 HOH 126 2226 263  HOH HOH B . 
M 3 HOH 127 2227 583  HOH HOH B . 
M 3 HOH 128 2228 719  HOH HOH B . 
M 3 HOH 129 2229 237  HOH HOH B . 
M 3 HOH 130 2230 695  HOH HOH B . 
M 3 HOH 131 2231 559  HOH HOH B . 
M 3 HOH 132 2232 265  HOH HOH B . 
M 3 HOH 133 2233 545  HOH HOH B . 
M 3 HOH 134 2234 394  HOH HOH B . 
M 3 HOH 135 2235 537  HOH HOH B . 
M 3 HOH 136 2236 279  HOH HOH B . 
M 3 HOH 137 2237 485  HOH HOH B . 
M 3 HOH 138 2238 601  HOH HOH B . 
M 3 HOH 139 2239 759  HOH HOH B . 
M 3 HOH 140 2240 767  HOH HOH B . 
M 3 HOH 141 2241 668  HOH HOH B . 
M 3 HOH 142 2242 401  HOH HOH B . 
M 3 HOH 143 2243 577  HOH HOH B . 
M 3 HOH 144 2244 673  HOH HOH B . 
M 3 HOH 145 2245 355  HOH HOH B . 
M 3 HOH 146 2246 589  HOH HOH B . 
M 3 HOH 147 2247 772  HOH HOH B . 
M 3 HOH 148 2248 276  HOH HOH B . 
M 3 HOH 149 2249 576  HOH HOH B . 
M 3 HOH 150 2250 361  HOH HOH B . 
M 3 HOH 151 2251 716  HOH HOH B . 
M 3 HOH 152 2252 419  HOH HOH B . 
M 3 HOH 153 2253 709  HOH HOH B . 
M 3 HOH 154 2254 764  HOH HOH B . 
M 3 HOH 155 2255 555  HOH HOH B . 
M 3 HOH 156 2256 526  HOH HOH B . 
M 3 HOH 157 2257 423  HOH HOH B . 
M 3 HOH 158 2258 773  HOH HOH B . 
M 3 HOH 159 2259 464  HOH HOH B . 
M 3 HOH 160 2260 602  HOH HOH B . 
M 3 HOH 161 2261 776  HOH HOH B . 
M 3 HOH 162 2262 446  HOH HOH B . 
M 3 HOH 163 2263 522  HOH HOH B . 
M 3 HOH 164 2264 753  HOH HOH B . 
M 3 HOH 165 2265 482  HOH HOH B . 
M 3 HOH 166 2266 708  HOH HOH B . 
M 3 HOH 167 2267 256  HOH HOH B . 
M 3 HOH 168 2268 406  HOH HOH B . 
M 3 HOH 169 2269 789  HOH HOH B . 
M 3 HOH 170 2270 542  HOH HOH B . 
M 3 HOH 171 2271 182  HOH HOH B . 
M 3 HOH 172 2272 769  HOH HOH B . 
M 3 HOH 173 2273 784  HOH HOH B . 
M 3 HOH 174 2274 675  HOH HOH B . 
M 3 HOH 175 2275 109  HOH HOH B . 
M 3 HOH 176 2276 775  HOH HOH B . 
M 3 HOH 177 2277 284  HOH HOH B . 
M 3 HOH 178 2278 539  HOH HOH B . 
M 3 HOH 179 2279 518  HOH HOH B . 
M 3 HOH 180 2280 343  HOH HOH B . 
M 3 HOH 181 2281 728  HOH HOH B . 
M 3 HOH 182 2282 693  HOH HOH B . 
M 3 HOH 183 2283 527  HOH HOH B . 
M 3 HOH 184 2284 778  HOH HOH B . 
M 3 HOH 185 2285 243  HOH HOH B . 
M 3 HOH 186 2286 416  HOH HOH B . 
M 3 HOH 187 2287 381  HOH HOH B . 
M 3 HOH 188 2288 51   HOH HOH B . 
M 3 HOH 189 2289 341  HOH HOH B . 
M 3 HOH 190 2290 585  HOH HOH B . 
M 3 HOH 191 2291 782  HOH HOH B . 
M 3 HOH 192 2292 242  HOH HOH B . 
M 3 HOH 193 2293 755  HOH HOH B . 
M 3 HOH 194 2294 631  HOH HOH B . 
M 3 HOH 195 2295 145  HOH HOH B . 
M 3 HOH 196 2296 584  HOH HOH B . 
M 3 HOH 197 2297 316  HOH HOH B . 
M 3 HOH 198 2298 372  HOH HOH B . 
M 3 HOH 199 2299 757  HOH HOH B . 
M 3 HOH 200 2300 689  HOH HOH B . 
M 3 HOH 201 2301 770  HOH HOH B . 
M 3 HOH 202 2302 307  HOH HOH B . 
M 3 HOH 203 2303 781  HOH HOH B . 
M 3 HOH 204 2304 185  HOH HOH B . 
M 3 HOH 205 2305 779  HOH HOH B . 
M 3 HOH 206 2306 771  HOH HOH B . 
N 3 HOH 1   2101 269  HOH HOH C . 
N 3 HOH 2   2102 662  HOH HOH C . 
N 3 HOH 3   2103 751  HOH HOH C . 
N 3 HOH 4   2104 270  HOH HOH C . 
N 3 HOH 5   2105 206  HOH HOH C . 
N 3 HOH 6   2106 557  HOH HOH C . 
N 3 HOH 7   2107 391  HOH HOH C . 
N 3 HOH 8   2108 642  HOH HOH C . 
N 3 HOH 9   2109 166  HOH HOH C . 
N 3 HOH 10  2110 474  HOH HOH C . 
N 3 HOH 11  2111 167  HOH HOH C . 
N 3 HOH 12  2112 161  HOH HOH C . 
N 3 HOH 13  2113 245  HOH HOH C . 
N 3 HOH 14  2114 608  HOH HOH C . 
N 3 HOH 15  2115 111  HOH HOH C . 
N 3 HOH 16  2116 144  HOH HOH C . 
N 3 HOH 17  2117 609  HOH HOH C . 
N 3 HOH 18  2118 544  HOH HOH C . 
N 3 HOH 19  2119 219  HOH HOH C . 
N 3 HOH 20  2120 334  HOH HOH C . 
N 3 HOH 21  2121 509  HOH HOH C . 
N 3 HOH 22  2122 404  HOH HOH C . 
N 3 HOH 23  2123 88   HOH HOH C . 
N 3 HOH 24  2124 232  HOH HOH C . 
N 3 HOH 25  2125 790  HOH HOH C . 
N 3 HOH 26  2126 7    HOH HOH C . 
N 3 HOH 27  2127 165  HOH HOH C . 
N 3 HOH 28  2128 133  HOH HOH C . 
N 3 HOH 29  2129 374  HOH HOH C . 
N 3 HOH 30  2130 63   HOH HOH C . 
N 3 HOH 31  2131 785  HOH HOH C . 
N 3 HOH 32  2132 561  HOH HOH C . 
N 3 HOH 33  2133 258  HOH HOH C . 
N 3 HOH 34  2134 173  HOH HOH C . 
N 3 HOH 35  2135 408  HOH HOH C . 
N 3 HOH 36  2136 246  HOH HOH C . 
N 3 HOH 37  2137 79   HOH HOH C . 
N 3 HOH 38  2138 210  HOH HOH C . 
N 3 HOH 39  2139 223  HOH HOH C . 
N 3 HOH 40  2140 83   HOH HOH C . 
N 3 HOH 41  2141 529  HOH HOH C . 
N 3 HOH 42  2142 38   HOH HOH C . 
N 3 HOH 43  2143 551  HOH HOH C . 
N 3 HOH 44  2144 64   HOH HOH C . 
N 3 HOH 45  2145 507  HOH HOH C . 
N 3 HOH 46  2146 266  HOH HOH C . 
N 3 HOH 47  2147 94   HOH HOH C . 
N 3 HOH 48  2148 207  HOH HOH C . 
N 3 HOH 49  2149 299  HOH HOH C . 
N 3 HOH 50  2150 627  HOH HOH C . 
N 3 HOH 51  2151 680  HOH HOH C . 
N 3 HOH 52  2152 192  HOH HOH C . 
N 3 HOH 53  2153 141  HOH HOH C . 
N 3 HOH 54  2154 4    HOH HOH C . 
N 3 HOH 55  2155 317  HOH HOH C . 
N 3 HOH 56  2156 68   HOH HOH C . 
N 3 HOH 57  2157 335  HOH HOH C . 
N 3 HOH 58  2158 27   HOH HOH C . 
N 3 HOH 59  2159 16   HOH HOH C . 
N 3 HOH 60  2160 453  HOH HOH C . 
N 3 HOH 61  2161 354  HOH HOH C . 
N 3 HOH 62  2162 183  HOH HOH C . 
N 3 HOH 63  2163 97   HOH HOH C . 
N 3 HOH 64  2164 5    HOH HOH C . 
N 3 HOH 65  2165 362  HOH HOH C . 
N 3 HOH 66  2166 214  HOH HOH C . 
N 3 HOH 67  2167 175  HOH HOH C . 
N 3 HOH 68  2168 293  HOH HOH C . 
N 3 HOH 69  2169 721  HOH HOH C . 
N 3 HOH 70  2170 89   HOH HOH C . 
N 3 HOH 71  2171 670  HOH HOH C . 
N 3 HOH 72  2172 230  HOH HOH C . 
N 3 HOH 73  2173 287  HOH HOH C . 
N 3 HOH 74  2174 417  HOH HOH C . 
N 3 HOH 75  2175 366  HOH HOH C . 
N 3 HOH 76  2176 143  HOH HOH C . 
N 3 HOH 77  2177 483  HOH HOH C . 
N 3 HOH 78  2178 314  HOH HOH C . 
N 3 HOH 79  2179 611  HOH HOH C . 
N 3 HOH 80  2180 674  HOH HOH C . 
N 3 HOH 81  2181 253  HOH HOH C . 
N 3 HOH 82  2182 351  HOH HOH C . 
N 3 HOH 83  2183 407  HOH HOH C . 
N 3 HOH 84  2184 500  HOH HOH C . 
N 3 HOH 85  2185 295  HOH HOH C . 
N 3 HOH 86  2186 113  HOH HOH C . 
N 3 HOH 87  2187 454  HOH HOH C . 
N 3 HOH 88  2188 512  HOH HOH C . 
N 3 HOH 89  2189 179  HOH HOH C . 
N 3 HOH 90  2190 178  HOH HOH C . 
N 3 HOH 91  2191 456  HOH HOH C . 
N 3 HOH 92  2192 280  HOH HOH C . 
N 3 HOH 93  2193 724  HOH HOH C . 
N 3 HOH 94  2194 413  HOH HOH C . 
N 3 HOH 95  2195 129  HOH HOH C . 
N 3 HOH 96  2196 74   HOH HOH C . 
N 3 HOH 97  2197 225  HOH HOH C . 
N 3 HOH 98  2198 123  HOH HOH C . 
N 3 HOH 99  2199 160  HOH HOH C . 
N 3 HOH 100 2200 152  HOH HOH C . 
N 3 HOH 101 2201 706  HOH HOH C . 
N 3 HOH 102 2202 598  HOH HOH C . 
N 3 HOH 103 2203 375  HOH HOH C . 
N 3 HOH 104 2204 30   HOH HOH C . 
N 3 HOH 105 2205 146  HOH HOH C . 
N 3 HOH 106 2206 329  HOH HOH C . 
N 3 HOH 107 2207 378  HOH HOH C . 
N 3 HOH 108 2208 788  HOH HOH C . 
N 3 HOH 109 2209 244  HOH HOH C . 
N 3 HOH 110 2210 530  HOH HOH C . 
N 3 HOH 111 2211 29   HOH HOH C . 
N 3 HOH 112 2212 176  HOH HOH C . 
N 3 HOH 113 2213 34   HOH HOH C . 
N 3 HOH 114 2214 657  HOH HOH C . 
N 3 HOH 115 2215 610  HOH HOH C . 
N 3 HOH 116 2216 350  HOH HOH C . 
N 3 HOH 117 2217 515  HOH HOH C . 
N 3 HOH 118 2218 3    HOH HOH C . 
N 3 HOH 119 2219 538  HOH HOH C . 
N 3 HOH 120 2220 455  HOH HOH C . 
N 3 HOH 121 2221 606  HOH HOH C . 
N 3 HOH 122 2222 684  HOH HOH C . 
N 3 HOH 123 2223 541  HOH HOH C . 
N 3 HOH 124 2224 672  HOH HOH C . 
N 3 HOH 125 2225 508  HOH HOH C . 
N 3 HOH 126 2226 513  HOH HOH C . 
N 3 HOH 127 2227 791  HOH HOH C . 
N 3 HOH 128 2228 510  HOH HOH C . 
N 3 HOH 129 2229 786  HOH HOH C . 
N 3 HOH 130 2230 385  HOH HOH C . 
N 3 HOH 131 2231 516  HOH HOH C . 
N 3 HOH 132 2232 501  HOH HOH C . 
N 3 HOH 133 2233 792  HOH HOH C . 
N 3 HOH 134 2234 470  HOH HOH C . 
N 3 HOH 135 2235 624  HOH HOH C . 
N 3 HOH 136 2236 438  HOH HOH C . 
N 3 HOH 137 2237 663  HOH HOH C . 
N 3 HOH 138 2238 384  HOH HOH C . 
N 3 HOH 139 2239 575  HOH HOH C . 
N 3 HOH 140 2240 444  HOH HOH C . 
N 3 HOH 141 2241 65   HOH HOH C . 
N 3 HOH 142 2242 701  HOH HOH C . 
N 3 HOH 143 2243 254  HOH HOH C . 
N 3 HOH 144 2244 566  HOH HOH C . 
N 3 HOH 145 2245 664  HOH HOH C . 
N 3 HOH 146 2246 218  HOH HOH C . 
N 3 HOH 147 2247 685  HOH HOH C . 
N 3 HOH 148 2248 103  HOH HOH C . 
N 3 HOH 149 2249 338  HOH HOH C . 
N 3 HOH 150 2250 554  HOH HOH C . 
N 3 HOH 151 2251 387  HOH HOH C . 
N 3 HOH 152 2252 649  HOH HOH C . 
N 3 HOH 153 2253 722  HOH HOH C . 
N 3 HOH 154 2254 339  HOH HOH C . 
N 3 HOH 155 2255 480  HOH HOH C . 
N 3 HOH 156 2256 503  HOH HOH C . 
N 3 HOH 157 2257 319  HOH HOH C . 
N 3 HOH 158 2258 383  HOH HOH C . 
N 3 HOH 159 2259 135  HOH HOH C . 
N 3 HOH 160 2260 613  HOH HOH C . 
N 3 HOH 161 2261 452  HOH HOH C . 
N 3 HOH 162 2262 499  HOH HOH C . 
N 3 HOH 163 2263 78   HOH HOH C . 
N 3 HOH 164 2264 484  HOH HOH C . 
N 3 HOH 165 2265 607  HOH HOH C . 
N 3 HOH 166 2266 205  HOH HOH C . 
N 3 HOH 167 2267 344  HOH HOH C . 
N 3 HOH 168 2268 667  HOH HOH C . 
N 3 HOH 169 2269 573  HOH HOH C . 
O 3 HOH 1   2101 471  HOH HOH D . 
O 3 HOH 2   2102 277  HOH HOH D . 
O 3 HOH 3   2103 502  HOH HOH D . 
O 3 HOH 4   2104 286  HOH HOH D . 
O 3 HOH 5   2105 466  HOH HOH D . 
O 3 HOH 6   2106 572  HOH HOH D . 
O 3 HOH 7   2107 190  HOH HOH D . 
O 3 HOH 8   2108 645  HOH HOH D . 
O 3 HOH 9   2109 496  HOH HOH D . 
O 3 HOH 10  2110 370  HOH HOH D . 
O 3 HOH 11  2111 267  HOH HOH D . 
O 3 HOH 12  2112 710  HOH HOH D . 
O 3 HOH 13  2113 14   HOH HOH D . 
O 3 HOH 14  2114 628  HOH HOH D . 
O 3 HOH 15  2115 272  HOH HOH D . 
O 3 HOH 16  2116 799  HOH HOH D . 
O 3 HOH 17  2117 58   HOH HOH D . 
O 3 HOH 18  2118 369  HOH HOH D . 
O 3 HOH 19  2119 238  HOH HOH D . 
O 3 HOH 20  2120 457  HOH HOH D . 
O 3 HOH 21  2121 147  HOH HOH D . 
O 3 HOH 22  2122 360  HOH HOH D . 
O 3 HOH 23  2123 39   HOH HOH D . 
O 3 HOH 24  2124 320  HOH HOH D . 
O 3 HOH 25  2125 248  HOH HOH D . 
O 3 HOH 26  2126 117  HOH HOH D . 
O 3 HOH 27  2127 121  HOH HOH D . 
O 3 HOH 28  2128 114  HOH HOH D . 
O 3 HOH 29  2129 400  HOH HOH D . 
O 3 HOH 30  2130 461  HOH HOH D . 
O 3 HOH 31  2131 798  HOH HOH D . 
O 3 HOH 32  2132 347  HOH HOH D . 
O 3 HOH 33  2133 239  HOH HOH D . 
O 3 HOH 34  2134 688  HOH HOH D . 
O 3 HOH 35  2135 348  HOH HOH D . 
O 3 HOH 36  2136 112  HOH HOH D . 
O 3 HOH 37  2137 106  HOH HOH D . 
O 3 HOH 38  2138 491  HOH HOH D . 
O 3 HOH 39  2139 327  HOH HOH D . 
O 3 HOH 40  2140 122  HOH HOH D . 
O 3 HOH 41  2141 571  HOH HOH D . 
O 3 HOH 42  2142 211  HOH HOH D . 
O 3 HOH 43  2143 465  HOH HOH D . 
O 3 HOH 44  2144 199  HOH HOH D . 
O 3 HOH 45  2145 203  HOH HOH D . 
O 3 HOH 46  2146 255  HOH HOH D . 
O 3 HOH 47  2147 119  HOH HOH D . 
O 3 HOH 48  2148 23   HOH HOH D . 
O 3 HOH 49  2149 45   HOH HOH D . 
O 3 HOH 50  2150 80   HOH HOH D . 
O 3 HOH 51  2151 75   HOH HOH D . 
O 3 HOH 52  2152 795  HOH HOH D . 
O 3 HOH 53  2153 333  HOH HOH D . 
O 3 HOH 54  2154 641  HOH HOH D . 
O 3 HOH 55  2155 494  HOH HOH D . 
O 3 HOH 56  2156 163  HOH HOH D . 
O 3 HOH 57  2157 18   HOH HOH D . 
O 3 HOH 58  2158 37   HOH HOH D . 
O 3 HOH 59  2159 8    HOH HOH D . 
O 3 HOH 60  2160 174  HOH HOH D . 
O 3 HOH 61  2161 249  HOH HOH D . 
O 3 HOH 62  2162 476  HOH HOH D . 
O 3 HOH 63  2163 634  HOH HOH D . 
O 3 HOH 64  2164 617  HOH HOH D . 
O 3 HOH 65  2165 193  HOH HOH D . 
O 3 HOH 66  2166 44   HOH HOH D . 
O 3 HOH 67  2167 636  HOH HOH D . 
O 3 HOH 68  2168 142  HOH HOH D . 
O 3 HOH 69  2169 402  HOH HOH D . 
O 3 HOH 70  2170 390  HOH HOH D . 
O 3 HOH 71  2171 197  HOH HOH D . 
O 3 HOH 72  2172 184  HOH HOH D . 
O 3 HOH 73  2173 540  HOH HOH D . 
O 3 HOH 74  2174 647  HOH HOH D . 
O 3 HOH 75  2175 102  HOH HOH D . 
O 3 HOH 76  2176 57   HOH HOH D . 
O 3 HOH 77  2177 59   HOH HOH D . 
O 3 HOH 78  2178 186  HOH HOH D . 
O 3 HOH 79  2179 56   HOH HOH D . 
O 3 HOH 80  2180 629  HOH HOH D . 
O 3 HOH 81  2181 285  HOH HOH D . 
O 3 HOH 82  2182 72   HOH HOH D . 
O 3 HOH 83  2183 172  HOH HOH D . 
O 3 HOH 84  2184 458  HOH HOH D . 
O 3 HOH 85  2185 194  HOH HOH D . 
O 3 HOH 86  2186 306  HOH HOH D . 
O 3 HOH 87  2187 98   HOH HOH D . 
O 3 HOH 88  2188 60   HOH HOH D . 
O 3 HOH 89  2189 124  HOH HOH D . 
O 3 HOH 90  2190 302  HOH HOH D . 
O 3 HOH 91  2191 582  HOH HOH D . 
O 3 HOH 92  2192 48   HOH HOH D . 
O 3 HOH 93  2193 273  HOH HOH D . 
O 3 HOH 94  2194 460  HOH HOH D . 
O 3 HOH 95  2195 85   HOH HOH D . 
O 3 HOH 96  2196 304  HOH HOH D . 
O 3 HOH 97  2197 202  HOH HOH D . 
O 3 HOH 98  2198 140  HOH HOH D . 
O 3 HOH 99  2199 495  HOH HOH D . 
O 3 HOH 100 2200 282  HOH HOH D . 
O 3 HOH 101 2201 318  HOH HOH D . 
O 3 HOH 102 2202 118  HOH HOH D . 
O 3 HOH 103 2203 421  HOH HOH D . 
O 3 HOH 104 2204 212  HOH HOH D . 
O 3 HOH 105 2205 159  HOH HOH D . 
O 3 HOH 106 2206 164  HOH HOH D . 
O 3 HOH 107 2207 325  HOH HOH D . 
O 3 HOH 108 2208 298  HOH HOH D . 
O 3 HOH 109 2209 556  HOH HOH D . 
O 3 HOH 110 2210 646  HOH HOH D . 
O 3 HOH 111 2211 616  HOH HOH D . 
O 3 HOH 112 2212 352  HOH HOH D . 
O 3 HOH 113 2213 46   HOH HOH D . 
O 3 HOH 114 2214 191  HOH HOH D . 
O 3 HOH 115 2215 187  HOH HOH D . 
O 3 HOH 116 2216 549  HOH HOH D . 
O 3 HOH 117 2217 227  HOH HOH D . 
O 3 HOH 118 2218 292  HOH HOH D . 
O 3 HOH 119 2219 520  HOH HOH D . 
O 3 HOH 120 2220 760  HOH HOH D . 
O 3 HOH 121 2221 564  HOH HOH D . 
O 3 HOH 122 2222 796  HOH HOH D . 
O 3 HOH 123 2223 442  HOH HOH D . 
O 3 HOH 124 2224 313  HOH HOH D . 
O 3 HOH 125 2225 95   HOH HOH D . 
O 3 HOH 126 2226 682  HOH HOH D . 
O 3 HOH 127 2227 345  HOH HOH D . 
O 3 HOH 128 2228 546  HOH HOH D . 
O 3 HOH 129 2229 171  HOH HOH D . 
O 3 HOH 130 2230 570  HOH HOH D . 
O 3 HOH 131 2231 660  HOH HOH D . 
O 3 HOH 132 2232 691  HOH HOH D . 
O 3 HOH 133 2233 274  HOH HOH D . 
O 3 HOH 134 2234 543  HOH HOH D . 
O 3 HOH 135 2235 797  HOH HOH D . 
O 3 HOH 136 2236 734  HOH HOH D . 
O 3 HOH 137 2237 336  HOH HOH D . 
O 3 HOH 138 2238 472  HOH HOH D . 
O 3 HOH 139 2239 418  HOH HOH D . 
O 3 HOH 140 2240 653  HOH HOH D . 
O 3 HOH 141 2241 315  HOH HOH D . 
O 3 HOH 142 2242 568  HOH HOH D . 
O 3 HOH 143 2243 475  HOH HOH D . 
O 3 HOH 144 2244 514  HOH HOH D . 
O 3 HOH 145 2245 158  HOH HOH D . 
O 3 HOH 146 2246 762  HOH HOH D . 
O 3 HOH 147 2247 377  HOH HOH D . 
O 3 HOH 148 2248 692  HOH HOH D . 
O 3 HOH 149 2249 630  HOH HOH D . 
O 3 HOH 150 2250 732  HOH HOH D . 
O 3 HOH 151 2251 669  HOH HOH D . 
O 3 HOH 152 2252 702  HOH HOH D . 
O 3 HOH 153 2253 311  HOH HOH D . 
O 3 HOH 154 2254 623  HOH HOH D . 
O 3 HOH 155 2255 578  HOH HOH D . 
O 3 HOH 156 2256 467  HOH HOH D . 
O 3 HOH 157 2257 605  HOH HOH D . 
O 3 HOH 158 2258 209  HOH HOH D . 
O 3 HOH 159 2259 330  HOH HOH D . 
O 3 HOH 160 2260 694  HOH HOH D . 
O 3 HOH 161 2261 581  HOH HOH D . 
O 3 HOH 162 2262 800  HOH HOH D . 
O 3 HOH 163 2263 397  HOH HOH D . 
O 3 HOH 164 2264 337  HOH HOH D . 
O 3 HOH 165 2265 364  HOH HOH D . 
O 3 HOH 166 2266 614  HOH HOH D . 
O 3 HOH 167 2267 536  HOH HOH D . 
O 3 HOH 168 2268 353  HOH HOH D . 
O 3 HOH 169 2269 459  HOH HOH D . 
O 3 HOH 170 2270 731  HOH HOH D . 
O 3 HOH 171 2271 379  HOH HOH D . 
O 3 HOH 172 2272 389  HOH HOH D . 
O 3 HOH 173 2273 481  HOH HOH D . 
O 3 HOH 174 2274 115  HOH HOH D . 
O 3 HOH 175 2275 715  HOH HOH D . 
O 3 HOH 176 2276 679  HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DENZO   ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZEV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     108.130 
_cell.length_a_esd                 ? 
_cell.length_b                     108.130 
_cell.length_b_esd                 ? 
_cell.length_c                     221.310 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZEV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZEV 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.32 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          62.99 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '20 mM Imidazole, pH 6.5, 10 mM Sodium Iodide, and 25% PEG4000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-03 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97853 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97853 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8ZEV 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.80 
_reflns.d_resolution_low                               35.39 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     139108 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                19.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          20.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.98 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.086 
_reflns.pdbx_Rpim_I_all                                0.019 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       2760557 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.084 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.80 
_reflns_shell.d_res_low                                     1.85 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           183066 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             10137 
_reflns_shell.percent_possible_obs                          100.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               18.1 
_reflns_shell.pdbx_chi_squared                              0.85 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     2.1 
_reflns_shell.pdbx_Rrim_I_all                               1.640 
_reflns_shell.pdbx_Rpim_I_all                               0.385 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.741 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.594 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZEV 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.80 
_refine.ls_d_res_low                             31.21 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     139013 
_refine.ls_number_reflns_R_free                  7117 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.99 
_refine.ls_percent_reflns_R_free                 5.12 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2083 
_refine.ls_R_factor_R_free                       0.2276 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2072 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.06 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.22 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.80 
_refine_hist.d_res_low                        31.21 
_refine_hist.number_atoms_solvent             747 
_refine_hist.number_atoms_total               8471 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        7717 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         7 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.009  ? 7953  ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.252  ? 10853 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 14.719 ? 2850  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.080  ? 1237  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.016  ? 1386  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.80 1.82  . . 239 4305 100.00 . . . . 0.2875 . . . . . . . . . . . 0.3064 
'X-RAY DIFFRACTION' 1.82 1.84  . . 230 4320 100.00 . . . . 0.2825 . . . . . . . . . . . 0.3350 
'X-RAY DIFFRACTION' 1.84 1.86  . . 274 4362 100.00 . . . . 0.2819 . . . . . . . . . . . 0.3080 
'X-RAY DIFFRACTION' 1.86 1.89  . . 213 4298 100.00 . . . . 0.2727 . . . . . . . . . . . 0.3077 
'X-RAY DIFFRACTION' 1.89 1.91  . . 246 4354 100.00 . . . . 0.3046 . . . . . . . . . . . 0.3392 
'X-RAY DIFFRACTION' 1.91 1.94  . . 260 4348 100.00 . . . . 0.2849 . . . . . . . . . . . 0.3157 
'X-RAY DIFFRACTION' 1.94 1.97  . . 247 4373 100.00 . . . . 0.2746 . . . . . . . . . . . 0.2931 
'X-RAY DIFFRACTION' 1.97 2.00  . . 241 4333 100.00 . . . . 0.2609 . . . . . . . . . . . 0.3037 
'X-RAY DIFFRACTION' 2.00 2.03  . . 244 4328 100.00 . . . . 0.2486 . . . . . . . . . . . 0.2650 
'X-RAY DIFFRACTION' 2.03 2.06  . . 196 4372 100.00 . . . . 0.2469 . . . . . . . . . . . 0.2794 
'X-RAY DIFFRACTION' 2.06 2.10  . . 202 4409 100.00 . . . . 0.2441 . . . . . . . . . . . 0.2540 
'X-RAY DIFFRACTION' 2.10 2.13  . . 220 4418 100.00 . . . . 0.2434 . . . . . . . . . . . 0.2604 
'X-RAY DIFFRACTION' 2.13 2.18  . . 265 4317 100.00 . . . . 0.2352 . . . . . . . . . . . 0.2625 
'X-RAY DIFFRACTION' 2.18 2.22  . . 268 4348 100.00 . . . . 0.2354 . . . . . . . . . . . 0.2720 
'X-RAY DIFFRACTION' 2.22 2.27  . . 240 4347 100.00 . . . . 0.2355 . . . . . . . . . . . 0.2732 
'X-RAY DIFFRACTION' 2.27 2.32  . . 249 4372 100.00 . . . . 0.2231 . . . . . . . . . . . 0.2231 
'X-RAY DIFFRACTION' 2.32 2.38  . . 210 4413 100.00 . . . . 0.2285 . . . . . . . . . . . 0.2372 
'X-RAY DIFFRACTION' 2.38 2.44  . . 235 4386 100.00 . . . . 0.2326 . . . . . . . . . . . 0.2719 
'X-RAY DIFFRACTION' 2.44 2.51  . . 228 4423 100.00 . . . . 0.2296 . . . . . . . . . . . 0.2533 
'X-RAY DIFFRACTION' 2.51 2.60  . . 242 4366 100.00 . . . . 0.2232 . . . . . . . . . . . 0.2525 
'X-RAY DIFFRACTION' 2.60 2.69  . . 238 4382 100.00 . . . . 0.2203 . . . . . . . . . . . 0.2568 
'X-RAY DIFFRACTION' 2.69 2.80  . . 198 4437 100.00 . . . . 0.2175 . . . . . . . . . . . 0.2463 
'X-RAY DIFFRACTION' 2.80 2.92  . . 195 4481 100.00 . . . . 0.2196 . . . . . . . . . . . 0.2281 
'X-RAY DIFFRACTION' 2.92 3.08  . . 226 4408 100.00 . . . . 0.2080 . . . . . . . . . . . 0.2267 
'X-RAY DIFFRACTION' 3.08 3.27  . . 266 4399 100.00 . . . . 0.2107 . . . . . . . . . . . 0.2254 
'X-RAY DIFFRACTION' 3.27 3.52  . . 264 4417 100.00 . . . . 0.1894 . . . . . . . . . . . 0.2256 
'X-RAY DIFFRACTION' 3.52 3.88  . . 262 4430 100.00 . . . . 0.1815 . . . . . . . . . . . 0.1867 
'X-RAY DIFFRACTION' 3.88 4.43  . . 256 4462 100.00 . . . . 0.1665 . . . . . . . . . . . 0.1999 
'X-RAY DIFFRACTION' 4.44 5.58  . . 226 4560 100.00 . . . . 0.1664 . . . . . . . . . . . 0.1774 
'X-RAY DIFFRACTION' 5.58 31.21 . . 237 4728 100.00 . . . . 0.2085 . . . . . . . . . . . 0.2121 
# 
_struct.entry_id                     8ZEV 
_struct.title                        'Crystal structure of the dehydratase domain of human fatty acid synthase' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZEV 
_struct_keywords.text            'Human; Fatty acid synthase; FASN; Dehydratase domain; DH, BIOSYNTHETIC PROTEIN' 
_struct_keywords.pdbx_keywords   'BIOSYNTHETIC PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 1 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
H N N 2 ? 
I N N 2 ? 
J N N 2 ? 
K N N 2 ? 
L N N 3 ? 
M N N 3 ? 
N N N 3 ? 
O N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    FAS_HUMAN 
_struct_ref.pdbx_db_accession          P49327 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRL
LEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDS
GRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGL
HTESA
;
_struct_ref.pdbx_align_begin           858 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZEV A 8 ? 252 ? P49327 858 ? 1102 ? 858 1102 
2 1 8ZEV B 8 ? 252 ? P49327 858 ? 1102 ? 858 1102 
3 1 8ZEV C 8 ? 252 ? P49327 858 ? 1102 ? 858 1102 
4 1 8ZEV D 8 ? 252 ? P49327 858 ? 1102 ? 858 1102 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZEV SER A 1 ? UNP P49327 ? ? 'expression tag' -7 1  
1 8ZEV GLU A 2 ? UNP P49327 ? ? 'expression tag' -6 2  
1 8ZEV ASN A 3 ? UNP P49327 ? ? 'expression tag' -5 3  
1 8ZEV LEU A 4 ? UNP P49327 ? ? 'expression tag' -4 4  
1 8ZEV TYR A 5 ? UNP P49327 ? ? 'expression tag' -3 5  
1 8ZEV PHE A 6 ? UNP P49327 ? ? 'expression tag' -2 6  
1 8ZEV GLN A 7 ? UNP P49327 ? ? 'expression tag' -1 7  
2 8ZEV SER B 1 ? UNP P49327 ? ? 'expression tag' -7 8  
2 8ZEV GLU B 2 ? UNP P49327 ? ? 'expression tag' -6 9  
2 8ZEV ASN B 3 ? UNP P49327 ? ? 'expression tag' -5 10 
2 8ZEV LEU B 4 ? UNP P49327 ? ? 'expression tag' -4 11 
2 8ZEV TYR B 5 ? UNP P49327 ? ? 'expression tag' -3 12 
2 8ZEV PHE B 6 ? UNP P49327 ? ? 'expression tag' -2 13 
2 8ZEV GLN B 7 ? UNP P49327 ? ? 'expression tag' -1 14 
3 8ZEV SER C 1 ? UNP P49327 ? ? 'expression tag' -7 15 
3 8ZEV GLU C 2 ? UNP P49327 ? ? 'expression tag' -6 16 
3 8ZEV ASN C 3 ? UNP P49327 ? ? 'expression tag' -5 17 
3 8ZEV LEU C 4 ? UNP P49327 ? ? 'expression tag' -4 18 
3 8ZEV TYR C 5 ? UNP P49327 ? ? 'expression tag' -3 19 
3 8ZEV PHE C 6 ? UNP P49327 ? ? 'expression tag' -2 20 
3 8ZEV GLN C 7 ? UNP P49327 ? ? 'expression tag' -1 21 
4 8ZEV SER D 1 ? UNP P49327 ? ? 'expression tag' -7 22 
4 8ZEV GLU D 2 ? UNP P49327 ? ? 'expression tag' -6 23 
4 8ZEV ASN D 3 ? UNP P49327 ? ? 'expression tag' -5 24 
4 8ZEV LEU D 4 ? UNP P49327 ? ? 'expression tag' -4 25 
4 8ZEV TYR D 5 ? UNP P49327 ? ? 'expression tag' -3 26 
4 8ZEV PHE D 6 ? UNP P49327 ? ? 'expression tag' -2 27 
4 8ZEV GLN D 7 ? UNP P49327 ? ? 'expression tag' -1 28 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2790  ? 
1 MORE         -4    ? 
1 'SSA (A^2)'  22800 ? 
2 'ABSA (A^2)' 2590  ? 
2 MORE         -4    ? 
2 'SSA (A^2)'  22600 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,E,F,L       
1 2 B,G,H,M       
2 1 C,D,I,J,K,N,O 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z             1.0000000000 0.0000000000 0.0000000000 0.0000000000  0.0000000000 
1.0000000000  0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 5_665 x-y+1,-y+1,-z+1/3 1.0000000000 0.0000000000 0.0000000000 54.0650000000 0.0000000000 
-1.0000000000 0.0000000000 93.6433269112 0.0000000000 0.0000000000 -1.0000000000 73.7700000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 22  ? VAL A 26  ? ASP A 872  VAL A 876  5 ? 5  
HELX_P HELX_P2  AA2 PRO A 37  ? GLY A 54  ? PRO A 887  GLY A 904  1 ? 18 
HELX_P HELX_P3  AA3 GLY A 56  ? LEU A 60  ? GLY A 906  LEU A 910  5 ? 5  
HELX_P HELX_P4  AA4 ASP A 115 ? ASP A 120 ? ASP A 965  ASP A 970  5 ? 6  
HELX_P HELX_P5  AA5 GLN A 137 ? ARG A 147 ? GLN A 987  ARG A 997  1 ? 11 
HELX_P HELX_P6  AA6 PRO A 153 ? GLN A 156 ? PRO A 1003 GLN A 1006 5 ? 4  
HELX_P HELX_P7  AA7 ASN A 175 ? GLY A 190 ? ASN A 1025 GLY A 1040 1 ? 16 
HELX_P HELX_P8  AA8 ASP A 208 ? LEU A 216 ? ASP A 1058 LEU A 1066 1 ? 9  
HELX_P HELX_P9  AA9 ASP B 22  ? VAL B 26  ? ASP B 872  VAL B 876  5 ? 5  
HELX_P HELX_P10 AB1 PRO B 37  ? GLY B 54  ? PRO B 887  GLY B 904  1 ? 18 
HELX_P HELX_P11 AB2 GLY B 56  ? LEU B 60  ? GLY B 906  LEU B 910  5 ? 5  
HELX_P HELX_P12 AB3 ASP B 115 ? ASP B 120 ? ASP B 965  ASP B 970  5 ? 6  
HELX_P HELX_P13 AB4 GLN B 137 ? ARG B 147 ? GLN B 987  ARG B 997  1 ? 11 
HELX_P HELX_P14 AB5 PRO B 153 ? GLN B 156 ? PRO B 1003 GLN B 1006 5 ? 4  
HELX_P HELX_P15 AB6 ASN B 175 ? GLY B 190 ? ASN B 1025 GLY B 1040 1 ? 16 
HELX_P HELX_P16 AB7 ASP B 208 ? LEU B 216 ? ASP B 1058 LEU B 1066 1 ? 9  
HELX_P HELX_P17 AB8 ASP C 22  ? VAL C 26  ? ASP C 872  VAL C 876  5 ? 5  
HELX_P HELX_P18 AB9 PRO C 37  ? GLY C 54  ? PRO C 887  GLY C 904  1 ? 18 
HELX_P HELX_P19 AC1 GLY C 56  ? LEU C 60  ? GLY C 906  LEU C 910  5 ? 5  
HELX_P HELX_P20 AC2 ASP C 115 ? ASP C 120 ? ASP C 965  ASP C 970  5 ? 6  
HELX_P HELX_P21 AC3 GLN C 137 ? ARG C 147 ? GLN C 987  ARG C 997  1 ? 11 
HELX_P HELX_P22 AC4 PRO C 153 ? GLN C 156 ? PRO C 1003 GLN C 1006 5 ? 4  
HELX_P HELX_P23 AC5 ASN C 175 ? GLY C 190 ? ASN C 1025 GLY C 1040 1 ? 16 
HELX_P HELX_P24 AC6 ASP C 208 ? LEU C 216 ? ASP C 1058 LEU C 1066 1 ? 9  
HELX_P HELX_P25 AC7 ASP D 22  ? VAL D 26  ? ASP D 872  VAL D 876  5 ? 5  
HELX_P HELX_P26 AC8 PRO D 37  ? GLY D 54  ? PRO D 887  GLY D 904  1 ? 18 
HELX_P HELX_P27 AC9 GLY D 56  ? LEU D 60  ? GLY D 906  LEU D 910  5 ? 5  
HELX_P HELX_P28 AD1 ASP D 115 ? ASP D 120 ? ASP D 965  ASP D 970  5 ? 6  
HELX_P HELX_P29 AD2 GLN D 137 ? GLY D 148 ? GLN D 987  GLY D 998  1 ? 12 
HELX_P HELX_P30 AD3 PRO D 153 ? GLN D 156 ? PRO D 1003 GLN D 1006 5 ? 4  
HELX_P HELX_P31 AD4 ASN D 175 ? GLY D 190 ? ASN D 1025 GLY D 1040 1 ? 16 
HELX_P HELX_P32 AD5 ASP D 208 ? LEU D 216 ? ASP D 1058 LEU D 1066 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 8  ? 
AA3 ? 3  ? 
AA4 ? 12 ? 
AA5 ? 10 ? 
AA6 ? 3  ? 
AA7 ? 24 ? 
AA8 ? 20 ? 
AA9 ? 3  ? 
AB1 ? 3  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA1 2  3  ? anti-parallel 
AA1 3  4  ? anti-parallel 
AA1 4  5  ? anti-parallel 
AA1 5  6  ? anti-parallel 
AA1 6  7  ? anti-parallel 
AA1 7  8  ? anti-parallel 
AA1 8  9  ? anti-parallel 
AA1 9  10 ? anti-parallel 
AA2 1  2  ? anti-parallel 
AA2 2  3  ? anti-parallel 
AA2 3  4  ? anti-parallel 
AA2 4  5  ? anti-parallel 
AA2 5  6  ? anti-parallel 
AA2 6  7  ? anti-parallel 
AA2 7  8  ? anti-parallel 
AA3 1  2  ? anti-parallel 
AA3 2  3  ? anti-parallel 
AA4 1  2  ? anti-parallel 
AA4 2  3  ? anti-parallel 
AA4 3  4  ? anti-parallel 
AA4 4  5  ? anti-parallel 
AA4 5  6  ? anti-parallel 
AA4 6  7  ? anti-parallel 
AA4 7  8  ? anti-parallel 
AA4 8  9  ? anti-parallel 
AA4 9  10 ? anti-parallel 
AA4 10 11 ? anti-parallel 
AA4 11 12 ? anti-parallel 
AA5 1  2  ? anti-parallel 
AA5 2  3  ? anti-parallel 
AA5 3  4  ? anti-parallel 
AA5 4  5  ? anti-parallel 
AA5 5  6  ? anti-parallel 
AA5 6  7  ? anti-parallel 
AA5 7  8  ? anti-parallel 
AA5 8  9  ? anti-parallel 
AA5 9  10 ? anti-parallel 
AA6 1  2  ? anti-parallel 
AA6 2  3  ? anti-parallel 
AA7 1  2  ? anti-parallel 
AA7 2  3  ? anti-parallel 
AA7 3  4  ? anti-parallel 
AA7 4  5  ? anti-parallel 
AA7 5  6  ? anti-parallel 
AA7 6  7  ? anti-parallel 
AA7 7  8  ? anti-parallel 
AA7 8  9  ? anti-parallel 
AA7 9  10 ? anti-parallel 
AA7 10 11 ? anti-parallel 
AA7 11 12 ? anti-parallel 
AA7 12 13 ? anti-parallel 
AA7 13 14 ? anti-parallel 
AA7 14 15 ? anti-parallel 
AA7 15 16 ? anti-parallel 
AA7 16 17 ? anti-parallel 
AA7 17 18 ? anti-parallel 
AA7 18 19 ? anti-parallel 
AA7 19 20 ? anti-parallel 
AA7 20 21 ? anti-parallel 
AA7 21 22 ? anti-parallel 
AA7 22 23 ? anti-parallel 
AA7 23 24 ? anti-parallel 
AA8 1  2  ? anti-parallel 
AA8 2  3  ? anti-parallel 
AA8 3  4  ? anti-parallel 
AA8 4  5  ? anti-parallel 
AA8 5  6  ? anti-parallel 
AA8 6  7  ? anti-parallel 
AA8 7  8  ? anti-parallel 
AA8 8  9  ? anti-parallel 
AA8 9  10 ? anti-parallel 
AA8 10 11 ? anti-parallel 
AA8 11 12 ? anti-parallel 
AA8 12 13 ? anti-parallel 
AA8 13 14 ? anti-parallel 
AA8 14 15 ? anti-parallel 
AA8 15 16 ? anti-parallel 
AA8 16 17 ? anti-parallel 
AA8 17 18 ? anti-parallel 
AA8 18 19 ? anti-parallel 
AA8 19 20 ? anti-parallel 
AA9 1  2  ? anti-parallel 
AA9 2  3  ? anti-parallel 
AB1 1  2  ? anti-parallel 
AB1 2  3  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  PHE A 6   ? ILE A 14  ? PHE A -2   ILE A 864  
AA1 2  VAL A 81  ? LEU A 88  ? VAL A 931  LEU A 938  
AA1 3  ALA A 93  ? GLU A 98  ? ALA A 943  GLU A 948  
AA1 4  ASN A 101 ? GLN A 110 ? ASN A 951  GLN A 960  
AA1 5  VAL A 62  ? LEU A 69  ? VAL A 912  LEU A 919  
AA1 6  TYR A 197 ? ILE A 207 ? TYR A 1047 ILE A 1057 
AA1 7  VAL A 242 ? SER A 245 ? VAL A 1092 SER A 1095 
AA1 8  VAL A 236 ? ALA A 239 ? VAL A 1086 ALA A 1089 
AA1 9  GLN A 224 ? SER A 231 ? GLN A 1074 SER A 1081 
AA1 10 TYR A 217 ? THR A 218 ? TYR A 1067 THR A 1068 
AA2 1  LEU A 135 ? ALA A 136 ? LEU A 985  ALA A 986  
AA2 2  ILE A 158 ? ALA A 161 ? ILE A 1008 ALA A 1011 
AA2 3  SER A 167 ? TRP A 172 ? SER A 1017 TRP A 1022 
AA2 4  GLN A 224 ? SER A 231 ? GLN A 1074 SER A 1081 
AA2 5  VAL A 236 ? ALA A 239 ? VAL A 1086 ALA A 1089 
AA2 6  VAL A 242 ? SER A 245 ? VAL A 1092 SER A 1095 
AA2 7  TYR A 197 ? ILE A 207 ? TYR A 1047 ILE A 1057 
AA2 8  HIS A 248 ? SER A 251 ? HIS A 1098 SER A 1101 
AA3 1  ARG A 33  ? VAL A 34  ? ARG A 883  VAL A 884  
AA3 2  HIS A 28  ? LEU A 30  ? HIS A 878  LEU A 880  
AA3 3  TYR A 149 ? TYR A 151 ? TYR A 999  TYR A 1001 
AA4 1  PHE B 6   ? ASP B 15  ? PHE B -2   ASP B 865  
AA4 2  THR B 80  ? LEU B 88  ? THR B 930  LEU B 938  
AA4 3  ALA B 93  ? GLU B 98  ? ALA B 943  GLU B 948  
AA4 4  ASN B 101 ? GLN B 110 ? ASN B 951  GLN B 960  
AA4 5  VAL B 62  ? LEU B 69  ? VAL B 912  LEU B 919  
AA4 6  TYR B 197 ? ILE B 207 ? TYR B 1047 ILE B 1057 
AA4 7  VAL B 242 ? SER B 251 ? VAL B 1092 SER B 1101 
AA4 8  VAL B 236 ? ALA B 239 ? VAL B 1086 ALA B 1089 
AA4 9  GLN B 224 ? SER B 231 ? GLN B 1074 SER B 1081 
AA4 10 SER B 167 ? TRP B 172 ? SER B 1017 TRP B 1022 
AA4 11 ILE B 158 ? ALA B 161 ? ILE B 1008 ALA B 1011 
AA4 12 LEU B 135 ? ALA B 136 ? LEU B 985  ALA B 986  
AA5 1  PHE B 6   ? ASP B 15  ? PHE B -2   ASP B 865  
AA5 2  THR B 80  ? LEU B 88  ? THR B 930  LEU B 938  
AA5 3  ALA B 93  ? GLU B 98  ? ALA B 943  GLU B 948  
AA5 4  ASN B 101 ? GLN B 110 ? ASN B 951  GLN B 960  
AA5 5  VAL B 62  ? LEU B 69  ? VAL B 912  LEU B 919  
AA5 6  TYR B 197 ? ILE B 207 ? TYR B 1047 ILE B 1057 
AA5 7  VAL B 242 ? SER B 251 ? VAL B 1092 SER B 1101 
AA5 8  VAL B 236 ? ALA B 239 ? VAL B 1086 ALA B 1089 
AA5 9  GLN B 224 ? SER B 231 ? GLN B 1074 SER B 1081 
AA5 10 TYR B 217 ? THR B 218 ? TYR B 1067 THR B 1068 
AA6 1  ARG B 33  ? VAL B 34  ? ARG B 883  VAL B 884  
AA6 2  HIS B 28  ? LEU B 30  ? HIS B 878  LEU B 880  
AA6 3  TYR B 149 ? TYR B 151 ? TYR B 999  TYR B 1001 
AA7 1  LEU C 135 ? ALA C 136 ? LEU C 985  ALA C 986  
AA7 2  ILE C 158 ? ALA C 161 ? ILE C 1008 ALA C 1011 
AA7 3  SER C 167 ? TRP C 172 ? SER C 1017 TRP C 1022 
AA7 4  GLN C 224 ? SER C 231 ? GLN C 1074 SER C 1081 
AA7 5  VAL C 236 ? ALA C 239 ? VAL C 1086 ALA C 1089 
AA7 6  VAL C 242 ? SER C 251 ? VAL C 1092 SER C 1101 
AA7 7  TYR C 197 ? ILE C 207 ? TYR C 1047 ILE C 1057 
AA7 8  VAL C 62  ? LEU C 69  ? VAL C 912  LEU C 919  
AA7 9  ASN C 101 ? GLN C 110 ? ASN C 951  GLN C 960  
AA7 10 ALA C 93  ? GLU C 98  ? ALA C 943  GLU C 948  
AA7 11 THR C 80  ? LEU C 88  ? THR C 930  LEU C 938  
AA7 12 GLU C 2   ? ASP C 15  ? GLU C -6   ASP C 865  
AA7 13 GLU D 2   ? ASP D 15  ? GLU D -6   ASP D 865  
AA7 14 THR D 80  ? LEU D 88  ? THR D 930  LEU D 938  
AA7 15 ALA D 93  ? GLU D 98  ? ALA D 943  GLU D 948  
AA7 16 ASN D 101 ? GLN D 110 ? ASN D 951  GLN D 960  
AA7 17 VAL D 62  ? LEU D 69  ? VAL D 912  LEU D 919  
AA7 18 TYR D 197 ? ILE D 207 ? TYR D 1047 ILE D 1057 
AA7 19 VAL D 242 ? SER D 251 ? VAL D 1092 SER D 1101 
AA7 20 VAL D 236 ? ALA D 239 ? VAL D 1086 ALA D 1089 
AA7 21 GLN D 224 ? SER D 231 ? GLN D 1074 SER D 1081 
AA7 22 SER D 167 ? TRP D 172 ? SER D 1017 TRP D 1022 
AA7 23 ILE D 158 ? ALA D 161 ? ILE D 1008 ALA D 1011 
AA7 24 LEU D 135 ? ALA D 136 ? LEU D 985  ALA D 986  
AA8 1  TYR C 217 ? THR C 218 ? TYR C 1067 THR C 1068 
AA8 2  GLN C 224 ? SER C 231 ? GLN C 1074 SER C 1081 
AA8 3  VAL C 236 ? ALA C 239 ? VAL C 1086 ALA C 1089 
AA8 4  VAL C 242 ? SER C 251 ? VAL C 1092 SER C 1101 
AA8 5  TYR C 197 ? ILE C 207 ? TYR C 1047 ILE C 1057 
AA8 6  VAL C 62  ? LEU C 69  ? VAL C 912  LEU C 919  
AA8 7  ASN C 101 ? GLN C 110 ? ASN C 951  GLN C 960  
AA8 8  ALA C 93  ? GLU C 98  ? ALA C 943  GLU C 948  
AA8 9  THR C 80  ? LEU C 88  ? THR C 930  LEU C 938  
AA8 10 GLU C 2   ? ASP C 15  ? GLU C -6   ASP C 865  
AA8 11 GLU D 2   ? ASP D 15  ? GLU D -6   ASP D 865  
AA8 12 THR D 80  ? LEU D 88  ? THR D 930  LEU D 938  
AA8 13 ALA D 93  ? GLU D 98  ? ALA D 943  GLU D 948  
AA8 14 ASN D 101 ? GLN D 110 ? ASN D 951  GLN D 960  
AA8 15 VAL D 62  ? LEU D 69  ? VAL D 912  LEU D 919  
AA8 16 TYR D 197 ? ILE D 207 ? TYR D 1047 ILE D 1057 
AA8 17 VAL D 242 ? SER D 251 ? VAL D 1092 SER D 1101 
AA8 18 VAL D 236 ? ALA D 239 ? VAL D 1086 ALA D 1089 
AA8 19 GLN D 224 ? SER D 231 ? GLN D 1074 SER D 1081 
AA8 20 TYR D 217 ? THR D 218 ? TYR D 1067 THR D 1068 
AA9 1  ARG C 33  ? VAL C 34  ? ARG C 883  VAL C 884  
AA9 2  HIS C 28  ? LEU C 30  ? HIS C 878  LEU C 880  
AA9 3  TYR C 149 ? TYR C 151 ? TYR C 999  TYR C 1001 
AB1 1  ARG D 33  ? VAL D 34  ? ARG D 883  VAL D 884  
AB1 2  HIS D 28  ? LEU D 30  ? HIS D 878  LEU D 880  
AB1 3  ASP D 150 ? TYR D 151 ? ASP D 1000 TYR D 1001 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N ILE A 14  ? N ILE A 864  O VAL A 81  ? O VAL A 931  
AA1 2  3  N GLU A 84  ? N GLU A 934  O SER A 97  ? O SER A 947  
AA1 3  4  N VAL A 96  ? N VAL A 946  O VAL A 103 ? O VAL A 953  
AA1 4  5  O SER A 105 ? O SER A 955  N VAL A 68  ? N VAL A 918  
AA1 5  6  N LEU A 69  ? N LEU A 919  O THR A 200 ? O THR A 1050 
AA1 6  7  N ALA A 204 ? N ALA A 1054 O SER A 245 ? O SER A 1095 
AA1 7  8  O ILE A 244 ? O ILE A 1094 N THR A 237 ? N THR A 1087 
AA1 8  9  O VAL A 236 ? O VAL A 1086 N SER A 231 ? N SER A 1081 
AA1 9  10 O VAL A 225 ? O VAL A 1075 N TYR A 217 ? N TYR A 1067 
AA2 1  2  N LEU A 135 ? N LEU A 985  O ALA A 161 ? O ALA A 1011 
AA2 2  3  N LEU A 159 ? N LEU A 1009 O ARG A 169 ? O ARG A 1019 
AA2 3  4  N LEU A 170 ? N LEU A 1020 O ALA A 226 ? O ALA A 1076 
AA2 4  5  N SER A 231 ? N SER A 1081 O VAL A 236 ? O VAL A 1086 
AA2 5  6  N THR A 237 ? N THR A 1087 O ILE A 244 ? O ILE A 1094 
AA2 6  7  O SER A 245 ? O SER A 1095 N ALA A 204 ? N ALA A 1054 
AA2 7  8  N THR A 200 ? N THR A 1050 O HIS A 248 ? O HIS A 1098 
AA3 1  2  O ARG A 33  ? O ARG A 883  N LEU A 30  ? N LEU A 880  
AA3 2  3  N THR A 29  ? N THR A 879  O ASP A 150 ? O ASP A 1000 
AA4 1  2  N ILE B 14  ? N ILE B 864  O VAL B 81  ? O VAL B 931  
AA4 2  3  N GLU B 84  ? N GLU B 934  O SER B 97  ? O SER B 947  
AA4 3  4  N VAL B 96  ? N VAL B 946  O VAL B 103 ? O VAL B 953  
AA4 4  5  O SER B 105 ? O SER B 955  N VAL B 68  ? N VAL B 918  
AA4 5  6  N PHE B 64  ? N PHE B 914  O ILE B 205 ? O ILE B 1055 
AA4 6  7  N ALA B 204 ? N ALA B 1054 O SER B 245 ? O SER B 1095 
AA4 7  8  O ILE B 244 ? O ILE B 1094 N THR B 237 ? N THR B 1087 
AA4 8  9  O VAL B 236 ? O VAL B 1086 N SER B 231 ? N SER B 1081 
AA4 9  10 O ALA B 226 ? O ALA B 1076 N LEU B 170 ? N LEU B 1020 
AA4 10 11 O ARG B 169 ? O ARG B 1019 N LEU B 159 ? N LEU B 1009 
AA4 11 12 O ALA B 161 ? O ALA B 1011 N LEU B 135 ? N LEU B 985  
AA5 1  2  N ILE B 14  ? N ILE B 864  O VAL B 81  ? O VAL B 931  
AA5 2  3  N GLU B 84  ? N GLU B 934  O SER B 97  ? O SER B 947  
AA5 3  4  N VAL B 96  ? N VAL B 946  O VAL B 103 ? O VAL B 953  
AA5 4  5  O SER B 105 ? O SER B 955  N VAL B 68  ? N VAL B 918  
AA5 5  6  N PHE B 64  ? N PHE B 914  O ILE B 205 ? O ILE B 1055 
AA5 6  7  N ALA B 204 ? N ALA B 1054 O SER B 245 ? O SER B 1095 
AA5 7  8  O ILE B 244 ? O ILE B 1094 N THR B 237 ? N THR B 1087 
AA5 8  9  O VAL B 236 ? O VAL B 1086 N SER B 231 ? N SER B 1081 
AA5 9  10 O VAL B 225 ? O VAL B 1075 N TYR B 217 ? N TYR B 1067 
AA6 1  2  O ARG B 33  ? O ARG B 883  N LEU B 30  ? N LEU B 880  
AA6 2  3  N THR B 29  ? N THR B 879  O ASP B 150 ? O ASP B 1000 
AA7 1  2  N LEU C 135 ? N LEU C 985  O ALA C 161 ? O ALA C 1011 
AA7 2  3  N LEU C 159 ? N LEU C 1009 O ARG C 169 ? O ARG C 1019 
AA7 3  4  N LEU C 170 ? N LEU C 1020 O ALA C 226 ? O ALA C 1076 
AA7 4  5  N SER C 231 ? N SER C 1081 O VAL C 236 ? O VAL C 1086 
AA7 5  6  N THR C 237 ? N THR C 1087 O ILE C 244 ? O ILE C 1094 
AA7 6  7  O HIS C 248 ? O HIS C 1098 N ARG C 201 ? N ARG C 1051 
AA7 7  8  O THR C 200 ? O THR C 1050 N LEU C 69  ? N LEU C 919  
AA7 8  9  N VAL C 68  ? N VAL C 918  O SER C 105 ? O SER C 955  
AA7 9  10 O VAL C 103 ? O VAL C 953  N VAL C 96  ? N VAL C 946  
AA7 10 11 O SER C 97  ? O SER C 947  N GLU C 84  ? N GLU C 934  
AA7 11 12 O VAL C 85  ? O VAL C 935  N ALA C 10  ? N ALA C 860  
AA7 12 13 N ILE C 11  ? N ILE C 861  O LEU D 4   ? O LEU D -4   
AA7 13 14 N ILE D 14  ? N ILE D 864  O VAL D 81  ? O VAL D 931  
AA7 14 15 N GLU D 84  ? N GLU D 934  O SER D 97  ? O SER D 947  
AA7 15 16 N VAL D 96  ? N VAL D 946  O VAL D 103 ? O VAL D 953  
AA7 16 17 O SER D 105 ? O SER D 955  N VAL D 68  ? N VAL D 918  
AA7 17 18 N PHE D 64  ? N PHE D 914  O ILE D 205 ? O ILE D 1055 
AA7 18 19 N ALA D 204 ? N ALA D 1054 O SER D 245 ? O SER D 1095 
AA7 19 20 O ILE D 244 ? O ILE D 1094 N THR D 237 ? N THR D 1087 
AA7 20 21 O VAL D 236 ? O VAL D 1086 N SER D 231 ? N SER D 1081 
AA7 21 22 O ALA D 226 ? O ALA D 1076 N LEU D 170 ? N LEU D 1020 
AA7 22 23 O ARG D 169 ? O ARG D 1019 N GLU D 160 ? N GLU D 1010 
AA7 23 24 O ALA D 161 ? O ALA D 1011 N LEU D 135 ? N LEU D 985  
AA8 1  2  N TYR C 217 ? N TYR C 1067 O VAL C 225 ? O VAL C 1075 
AA8 2  3  N SER C 231 ? N SER C 1081 O VAL C 236 ? O VAL C 1086 
AA8 3  4  N THR C 237 ? N THR C 1087 O ILE C 244 ? O ILE C 1094 
AA8 4  5  O HIS C 248 ? O HIS C 1098 N ARG C 201 ? N ARG C 1051 
AA8 5  6  O THR C 200 ? O THR C 1050 N LEU C 69  ? N LEU C 919  
AA8 6  7  N VAL C 68  ? N VAL C 918  O SER C 105 ? O SER C 955  
AA8 7  8  O VAL C 103 ? O VAL C 953  N VAL C 96  ? N VAL C 946  
AA8 8  9  O SER C 97  ? O SER C 947  N GLU C 84  ? N GLU C 934  
AA8 9  10 O VAL C 85  ? O VAL C 935  N ALA C 10  ? N ALA C 860  
AA8 10 11 N ILE C 11  ? N ILE C 861  O LEU D 4   ? O LEU D -4   
AA8 11 12 N ILE D 14  ? N ILE D 864  O VAL D 81  ? O VAL D 931  
AA8 12 13 N GLU D 84  ? N GLU D 934  O SER D 97  ? O SER D 947  
AA8 13 14 N VAL D 96  ? N VAL D 946  O VAL D 103 ? O VAL D 953  
AA8 14 15 O SER D 105 ? O SER D 955  N VAL D 68  ? N VAL D 918  
AA8 15 16 N PHE D 64  ? N PHE D 914  O ILE D 205 ? O ILE D 1055 
AA8 16 17 N ALA D 204 ? N ALA D 1054 O SER D 245 ? O SER D 1095 
AA8 17 18 O ILE D 244 ? O ILE D 1094 N THR D 237 ? N THR D 1087 
AA8 18 19 O VAL D 236 ? O VAL D 1086 N SER D 231 ? N SER D 1081 
AA8 19 20 O VAL D 225 ? O VAL D 1075 N TYR D 217 ? N TYR D 1067 
AA9 1  2  O ARG C 33  ? O ARG C 883  N LEU C 30  ? N LEU C 880  
AA9 2  3  N THR C 29  ? N THR C 879  O ASP C 150 ? O ASP C 1000 
AB1 1  2  O ARG D 33  ? O ARG D 883  N LEU D 30  ? N LEU D 880  
AB1 2  3  N THR D 29  ? N THR D 879  O ASP D 150 ? O ASP D 1000 
# 
_pdbx_entry_details.entry_id                   8ZEV 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO A 977  ? ? -59.51  -176.65 
2 1 ASP B 963  ? ? 43.67   72.51   
3 1 LYS B 1072 ? ? 84.71   0.35    
4 1 HIS C 878  ? ? -112.72 76.36   
5 1 ASP C 881  ? ? 72.50   -119.42 
6 1 PRO C 926  ? ? -63.58  -177.49 
7 1 ASP C 963  ? ? 29.33   81.23   
8 1 LYS C 1072 ? ? 82.54   -6.03   
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    B 
_pdbx_validate_planes.auth_seq_id     1063 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.196 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B PRO 972 ? B PRO 122 
2  1 Y 1 B GLU 973 ? B GLU 123 
3  1 Y 1 B SER 974 ? B SER 124 
4  1 Y 1 B PRO 975 ? B PRO 125 
5  1 Y 1 B THR 976 ? B THR 126 
6  1 Y 1 B PRO 977 ? B PRO 127 
7  1 Y 1 B ASN 978 ? B ASN 128 
8  1 Y 1 B PRO 979 ? B PRO 129 
9  1 Y 1 B THR 980 ? B THR 130 
10 1 Y 1 B GLU 981 ? B GLU 131 
11 1 Y 1 B PRO 982 ? B PRO 132 
12 1 Y 1 C PRO 977 ? C PRO 127 
13 1 Y 1 C ASN 978 ? C ASN 128 
14 1 Y 1 C PRO 979 ? C PRO 129 
15 1 Y 1 C THR 980 ? C THR 130 
16 1 Y 1 C GLU 981 ? C GLU 131 
17 1 Y 1 C PRO 982 ? C PRO 132 
18 1 Y 1 C LEU 983 ? C LEU 133 
19 1 Y 1 D PRO 972 ? D PRO 122 
20 1 Y 1 D GLU 973 ? D GLU 123 
21 1 Y 1 D SER 974 ? D SER 124 
22 1 Y 1 D PRO 975 ? D PRO 125 
23 1 Y 1 D THR 976 ? D THR 126 
24 1 Y 1 D PRO 977 ? D PRO 127 
25 1 Y 1 D ASN 978 ? D ASN 128 
26 1 Y 1 D PRO 979 ? D PRO 129 
27 1 Y 1 D THR 980 ? D THR 130 
28 1 Y 1 D GLU 981 ? D GLU 131 
29 1 Y 1 D PRO 982 ? D PRO 132 
30 1 Y 1 D LEU 983 ? D LEU 133 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
GLN N    N N N 74  
GLN CA   C N S 75  
GLN C    C N N 76  
GLN O    O N N 77  
GLN CB   C N N 78  
GLN CG   C N N 79  
GLN CD   C N N 80  
GLN OE1  O N N 81  
GLN NE2  N N N 82  
GLN OXT  O N N 83  
GLN H    H N N 84  
GLN H2   H N N 85  
GLN HA   H N N 86  
GLN HB2  H N N 87  
GLN HB3  H N N 88  
GLN HG2  H N N 89  
GLN HG3  H N N 90  
GLN HE21 H N N 91  
GLN HE22 H N N 92  
GLN HXT  H N N 93  
GLU N    N N N 94  
GLU CA   C N S 95  
GLU C    C N N 96  
GLU O    O N N 97  
GLU CB   C N N 98  
GLU CG   C N N 99  
GLU CD   C N N 100 
GLU OE1  O N N 101 
GLU OE2  O N N 102 
GLU OXT  O N N 103 
GLU H    H N N 104 
GLU H2   H N N 105 
GLU HA   H N N 106 
GLU HB2  H N N 107 
GLU HB3  H N N 108 
GLU HG2  H N N 109 
GLU HG3  H N N 110 
GLU HE2  H N N 111 
GLU HXT  H N N 112 
GLY N    N N N 113 
GLY CA   C N N 114 
GLY C    C N N 115 
GLY O    O N N 116 
GLY OXT  O N N 117 
GLY H    H N N 118 
GLY H2   H N N 119 
GLY HA2  H N N 120 
GLY HA3  H N N 121 
GLY HXT  H N N 122 
HIS N    N N N 123 
HIS CA   C N S 124 
HIS C    C N N 125 
HIS O    O N N 126 
HIS CB   C N N 127 
HIS CG   C Y N 128 
HIS ND1  N Y N 129 
HIS CD2  C Y N 130 
HIS CE1  C Y N 131 
HIS NE2  N Y N 132 
HIS OXT  O N N 133 
HIS H    H N N 134 
HIS H2   H N N 135 
HIS HA   H N N 136 
HIS HB2  H N N 137 
HIS HB3  H N N 138 
HIS HD1  H N N 139 
HIS HD2  H N N 140 
HIS HE1  H N N 141 
HIS HE2  H N N 142 
HIS HXT  H N N 143 
HOH O    O N N 144 
HOH H1   H N N 145 
HOH H2   H N N 146 
ILE N    N N N 147 
ILE CA   C N S 148 
ILE C    C N N 149 
ILE O    O N N 150 
ILE CB   C N S 151 
ILE CG1  C N N 152 
ILE CG2  C N N 153 
ILE CD1  C N N 154 
ILE OXT  O N N 155 
ILE H    H N N 156 
ILE H2   H N N 157 
ILE HA   H N N 158 
ILE HB   H N N 159 
ILE HG12 H N N 160 
ILE HG13 H N N 161 
ILE HG21 H N N 162 
ILE HG22 H N N 163 
ILE HG23 H N N 164 
ILE HD11 H N N 165 
ILE HD12 H N N 166 
ILE HD13 H N N 167 
ILE HXT  H N N 168 
IOD I    I N N 169 
LEU N    N N N 170 
LEU CA   C N S 171 
LEU C    C N N 172 
LEU O    O N N 173 
LEU CB   C N N 174 
LEU CG   C N N 175 
LEU CD1  C N N 176 
LEU CD2  C N N 177 
LEU OXT  O N N 178 
LEU H    H N N 179 
LEU H2   H N N 180 
LEU HA   H N N 181 
LEU HB2  H N N 182 
LEU HB3  H N N 183 
LEU HG   H N N 184 
LEU HD11 H N N 185 
LEU HD12 H N N 186 
LEU HD13 H N N 187 
LEU HD21 H N N 188 
LEU HD22 H N N 189 
LEU HD23 H N N 190 
LEU HXT  H N N 191 
LYS N    N N N 192 
LYS CA   C N S 193 
LYS C    C N N 194 
LYS O    O N N 195 
LYS CB   C N N 196 
LYS CG   C N N 197 
LYS CD   C N N 198 
LYS CE   C N N 199 
LYS NZ   N N N 200 
LYS OXT  O N N 201 
LYS H    H N N 202 
LYS H2   H N N 203 
LYS HA   H N N 204 
LYS HB2  H N N 205 
LYS HB3  H N N 206 
LYS HG2  H N N 207 
LYS HG3  H N N 208 
LYS HD2  H N N 209 
LYS HD3  H N N 210 
LYS HE2  H N N 211 
LYS HE3  H N N 212 
LYS HZ1  H N N 213 
LYS HZ2  H N N 214 
LYS HZ3  H N N 215 
LYS HXT  H N N 216 
MET N    N N N 217 
MET CA   C N S 218 
MET C    C N N 219 
MET O    O N N 220 
MET CB   C N N 221 
MET CG   C N N 222 
MET SD   S N N 223 
MET CE   C N N 224 
MET OXT  O N N 225 
MET H    H N N 226 
MET H2   H N N 227 
MET HA   H N N 228 
MET HB2  H N N 229 
MET HB3  H N N 230 
MET HG2  H N N 231 
MET HG3  H N N 232 
MET HE1  H N N 233 
MET HE2  H N N 234 
MET HE3  H N N 235 
MET HXT  H N N 236 
PHE N    N N N 237 
PHE CA   C N S 238 
PHE C    C N N 239 
PHE O    O N N 240 
PHE CB   C N N 241 
PHE CG   C Y N 242 
PHE CD1  C Y N 243 
PHE CD2  C Y N 244 
PHE CE1  C Y N 245 
PHE CE2  C Y N 246 
PHE CZ   C Y N 247 
PHE OXT  O N N 248 
PHE H    H N N 249 
PHE H2   H N N 250 
PHE HA   H N N 251 
PHE HB2  H N N 252 
PHE HB3  H N N 253 
PHE HD1  H N N 254 
PHE HD2  H N N 255 
PHE HE1  H N N 256 
PHE HE2  H N N 257 
PHE HZ   H N N 258 
PHE HXT  H N N 259 
PRO N    N N N 260 
PRO CA   C N S 261 
PRO C    C N N 262 
PRO O    O N N 263 
PRO CB   C N N 264 
PRO CG   C N N 265 
PRO CD   C N N 266 
PRO OXT  O N N 267 
PRO H    H N N 268 
PRO HA   H N N 269 
PRO HB2  H N N 270 
PRO HB3  H N N 271 
PRO HG2  H N N 272 
PRO HG3  H N N 273 
PRO HD2  H N N 274 
PRO HD3  H N N 275 
PRO HXT  H N N 276 
SER N    N N N 277 
SER CA   C N S 278 
SER C    C N N 279 
SER O    O N N 280 
SER CB   C N N 281 
SER OG   O N N 282 
SER OXT  O N N 283 
SER H    H N N 284 
SER H2   H N N 285 
SER HA   H N N 286 
SER HB2  H N N 287 
SER HB3  H N N 288 
SER HG   H N N 289 
SER HXT  H N N 290 
THR N    N N N 291 
THR CA   C N S 292 
THR C    C N N 293 
THR O    O N N 294 
THR CB   C N R 295 
THR OG1  O N N 296 
THR CG2  C N N 297 
THR OXT  O N N 298 
THR H    H N N 299 
THR H2   H N N 300 
THR HA   H N N 301 
THR HB   H N N 302 
THR HG1  H N N 303 
THR HG21 H N N 304 
THR HG22 H N N 305 
THR HG23 H N N 306 
THR HXT  H N N 307 
TRP N    N N N 308 
TRP CA   C N S 309 
TRP C    C N N 310 
TRP O    O N N 311 
TRP CB   C N N 312 
TRP CG   C Y N 313 
TRP CD1  C Y N 314 
TRP CD2  C Y N 315 
TRP NE1  N Y N 316 
TRP CE2  C Y N 317 
TRP CE3  C Y N 318 
TRP CZ2  C Y N 319 
TRP CZ3  C Y N 320 
TRP CH2  C Y N 321 
TRP OXT  O N N 322 
TRP H    H N N 323 
TRP H2   H N N 324 
TRP HA   H N N 325 
TRP HB2  H N N 326 
TRP HB3  H N N 327 
TRP HD1  H N N 328 
TRP HE1  H N N 329 
TRP HE3  H N N 330 
TRP HZ2  H N N 331 
TRP HZ3  H N N 332 
TRP HH2  H N N 333 
TRP HXT  H N N 334 
TYR N    N N N 335 
TYR CA   C N S 336 
TYR C    C N N 337 
TYR O    O N N 338 
TYR CB   C N N 339 
TYR CG   C Y N 340 
TYR CD1  C Y N 341 
TYR CD2  C Y N 342 
TYR CE1  C Y N 343 
TYR CE2  C Y N 344 
TYR CZ   C Y N 345 
TYR OH   O N N 346 
TYR OXT  O N N 347 
TYR H    H N N 348 
TYR H2   H N N 349 
TYR HA   H N N 350 
TYR HB2  H N N 351 
TYR HB3  H N N 352 
TYR HD1  H N N 353 
TYR HD2  H N N 354 
TYR HE1  H N N 355 
TYR HE2  H N N 356 
TYR HH   H N N 357 
TYR HXT  H N N 358 
VAL N    N N N 359 
VAL CA   C N S 360 
VAL C    C N N 361 
VAL O    O N N 362 
VAL CB   C N N 363 
VAL CG1  C N N 364 
VAL CG2  C N N 365 
VAL OXT  O N N 366 
VAL H    H N N 367 
VAL H2   H N N 368 
VAL HA   H N N 369 
VAL HB   H N N 370 
VAL HG11 H N N 371 
VAL HG12 H N N 372 
VAL HG13 H N N 373 
VAL HG21 H N N 374 
VAL HG22 H N N 375 
VAL HG23 H N N 376 
VAL HXT  H N N 377 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
THR N   CA   sing N N 277 
THR N   H    sing N N 278 
THR N   H2   sing N N 279 
THR CA  C    sing N N 280 
THR CA  CB   sing N N 281 
THR CA  HA   sing N N 282 
THR C   O    doub N N 283 
THR C   OXT  sing N N 284 
THR CB  OG1  sing N N 285 
THR CB  CG2  sing N N 286 
THR CB  HB   sing N N 287 
THR OG1 HG1  sing N N 288 
THR CG2 HG21 sing N N 289 
THR CG2 HG22 sing N N 290 
THR CG2 HG23 sing N N 291 
THR OXT HXT  sing N N 292 
TRP N   CA   sing N N 293 
TRP N   H    sing N N 294 
TRP N   H2   sing N N 295 
TRP CA  C    sing N N 296 
TRP CA  CB   sing N N 297 
TRP CA  HA   sing N N 298 
TRP C   O    doub N N 299 
TRP C   OXT  sing N N 300 
TRP CB  CG   sing N N 301 
TRP CB  HB2  sing N N 302 
TRP CB  HB3  sing N N 303 
TRP CG  CD1  doub Y N 304 
TRP CG  CD2  sing Y N 305 
TRP CD1 NE1  sing Y N 306 
TRP CD1 HD1  sing N N 307 
TRP CD2 CE2  doub Y N 308 
TRP CD2 CE3  sing Y N 309 
TRP NE1 CE2  sing Y N 310 
TRP NE1 HE1  sing N N 311 
TRP CE2 CZ2  sing Y N 312 
TRP CE3 CZ3  doub Y N 313 
TRP CE3 HE3  sing N N 314 
TRP CZ2 CH2  doub Y N 315 
TRP CZ2 HZ2  sing N N 316 
TRP CZ3 CH2  sing Y N 317 
TRP CZ3 HZ3  sing N N 318 
TRP CH2 HH2  sing N N 319 
TRP OXT HXT  sing N N 320 
TYR N   CA   sing N N 321 
TYR N   H    sing N N 322 
TYR N   H2   sing N N 323 
TYR CA  C    sing N N 324 
TYR CA  CB   sing N N 325 
TYR CA  HA   sing N N 326 
TYR C   O    doub N N 327 
TYR C   OXT  sing N N 328 
TYR CB  CG   sing N N 329 
TYR CB  HB2  sing N N 330 
TYR CB  HB3  sing N N 331 
TYR CG  CD1  doub Y N 332 
TYR CG  CD2  sing Y N 333 
TYR CD1 CE1  sing Y N 334 
TYR CD1 HD1  sing N N 335 
TYR CD2 CE2  doub Y N 336 
TYR CD2 HD2  sing N N 337 
TYR CE1 CZ   doub Y N 338 
TYR CE1 HE1  sing N N 339 
TYR CE2 CZ   sing Y N 340 
TYR CE2 HE2  sing N N 341 
TYR CZ  OH   sing N N 342 
TYR OH  HH   sing N N 343 
TYR OXT HXT  sing N N 344 
VAL N   CA   sing N N 345 
VAL N   H    sing N N 346 
VAL N   H2   sing N N 347 
VAL CA  C    sing N N 348 
VAL CA  CB   sing N N 349 
VAL CA  HA   sing N N 350 
VAL C   O    doub N N 351 
VAL C   OXT  sing N N 352 
VAL CB  CG1  sing N N 353 
VAL CB  CG2  sing N N 354 
VAL CB  HB   sing N N 355 
VAL CG1 HG11 sing N N 356 
VAL CG1 HG12 sing N N 357 
VAL CG1 HG13 sing N N 358 
VAL CG2 HG21 sing N N 359 
VAL CG2 HG22 sing N N 360 
VAL CG2 HG23 sing N N 361 
VAL OXT HXT  sing N N 362 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           22077081 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2vz8 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8ZEV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009248 
_atom_sites.fract_transf_matrix[1][2]   0.005339 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010679 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.004519 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
I 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? -40.053  17.862 35.320  1.00 44.46  ? -7   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? -40.844  18.961 34.776  1.00 42.28  ? -7   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? -41.911  18.452 33.822  1.00 39.66  ? -7   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? -41.711  17.442 33.149  1.00 45.47  ? -7   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? -39.939  19.971 34.065  1.00 38.06  ? -7   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? -39.089  19.325 33.133  1.00 42.46  ? -7   SER A OG  1 
ATOM   7    N N   . GLU A 1 2   ? -43.043  19.152 33.759  1.00 43.02  ? -6   GLU A N   1 
ATOM   8    C CA  . GLU A 1 2   ? -44.006  18.937 32.687  1.00 42.15  ? -6   GLU A CA  1 
ATOM   9    C C   . GLU A 1 2   ? -43.573  19.805 31.517  1.00 39.06  ? -6   GLU A C   1 
ATOM   10   O O   . GLU A 1 2   ? -43.509  21.032 31.643  1.00 35.84  ? -6   GLU A O   1 
ATOM   11   C CB  . GLU A 1 2   ? -45.431  19.315 33.091  1.00 45.39  ? -6   GLU A CB  1 
ATOM   12   C CG  . GLU A 1 2   ? -46.425  19.046 31.954  1.00 51.07  ? -6   GLU A CG  1 
ATOM   13   C CD  . GLU A 1 2   ? -47.571  20.047 31.862  1.00 60.09  ? -6   GLU A CD  1 
ATOM   14   O OE1 . GLU A 1 2   ? -47.377  21.234 32.204  1.00 49.34  ? -6   GLU A OE1 1 
ATOM   15   O OE2 . GLU A 1 2   ? -48.669  19.641 31.427  1.00 60.63  ? -6   GLU A OE2 1 
ATOM   16   N N   . ASN A 1 3   ? -43.325  19.181 30.372  1.00 31.58  ? -5   ASN A N   1 
ATOM   17   C CA  . ASN A 1 3   ? -42.733  19.862 29.230  1.00 30.32  ? -5   ASN A CA  1 
ATOM   18   C C   . ASN A 1 3   ? -43.774  20.005 28.129  1.00 36.46  ? -5   ASN A C   1 
ATOM   19   O O   . ASN A 1 3   ? -44.526  19.065 27.852  1.00 36.94  ? -5   ASN A O   1 
ATOM   20   C CB  . ASN A 1 3   ? -41.504  19.110 28.710  1.00 32.34  ? -5   ASN A CB  1 
ATOM   21   C CG  . ASN A 1 3   ? -40.431  18.927 29.773  1.00 33.30  ? -5   ASN A CG  1 
ATOM   22   O OD1 . ASN A 1 3   ? -40.461  19.566 30.825  1.00 30.48  ? -5   ASN A OD1 1 
ATOM   23   N ND2 . ASN A 1 3   ? -39.473  18.049 29.496  1.00 35.08  ? -5   ASN A ND2 1 
ATOM   24   N N   . LEU A 1 4   ? -43.848  21.200 27.549  1.00 30.53  ? -4   LEU A N   1 
ATOM   25   C CA  . LEU A 1 4   ? -44.775  21.524 26.473  1.00 28.88  ? -4   LEU A CA  1 
ATOM   26   C C   . LEU A 1 4   ? -43.968  21.989 25.267  1.00 28.87  ? -4   LEU A C   1 
ATOM   27   O O   . LEU A 1 4   ? -43.147  22.902 25.392  1.00 26.78  ? -4   LEU A O   1 
ATOM   28   C CB  . LEU A 1 4   ? -45.742  22.616 26.932  1.00 27.90  ? -4   LEU A CB  1 
ATOM   29   C CG  . LEU A 1 4   ? -46.585  22.259 28.161  1.00 32.72  ? -4   LEU A CG  1 
ATOM   30   C CD1 . LEU A 1 4   ? -47.387  23.462 28.634  1.00 32.79  ? -4   LEU A CD1 1 
ATOM   31   C CD2 . LEU A 1 4   ? -47.501  21.078 27.877  1.00 37.23  ? -4   LEU A CD2 1 
ATOM   32   N N   . TYR A 1 5   ? -44.203  21.387 24.101  1.00 28.60  ? -3   TYR A N   1 
ATOM   33   C CA  . TYR A 1 5   ? -43.374  21.652 22.930  1.00 25.52  ? -3   TYR A CA  1 
ATOM   34   C C   . TYR A 1 5   ? -44.168  22.338 21.824  1.00 27.08  ? -3   TYR A C   1 
ATOM   35   O O   . TYR A 1 5   ? -45.372  22.114 21.668  1.00 27.85  ? -3   TYR A O   1 
ATOM   36   C CB  . TYR A 1 5   ? -42.754  20.358 22.399  1.00 29.66  ? -3   TYR A CB  1 
ATOM   37   C CG  . TYR A 1 5   ? -41.885  19.677 23.427  1.00 32.26  ? -3   TYR A CG  1 
ATOM   38   C CD1 . TYR A 1 5   ? -40.635  20.182 23.767  1.00 31.15  ? -3   TYR A CD1 1 
ATOM   39   C CD2 . TYR A 1 5   ? -42.332  18.541 24.083  1.00 32.72  ? -3   TYR A CD2 1 
ATOM   40   C CE1 . TYR A 1 5   ? -39.850  19.558 24.725  1.00 31.14  ? -3   TYR A CE1 1 
ATOM   41   C CE2 . TYR A 1 5   ? -41.560  17.913 25.035  1.00 36.85  ? -3   TYR A CE2 1 
ATOM   42   C CZ  . TYR A 1 5   ? -40.322  18.422 25.354  1.00 35.65  ? -3   TYR A CZ  1 
ATOM   43   O OH  . TYR A 1 5   ? -39.562  17.783 26.307  1.00 38.98  ? -3   TYR A OH  1 
ATOM   44   N N   . PHE A 1 6   ? -43.475  23.178 21.051  1.00 26.23  ? -2   PHE A N   1 
ATOM   45   C CA  . PHE A 1 6   ? -44.096  23.992 20.012  1.00 25.83  ? -2   PHE A CA  1 
ATOM   46   C C   . PHE A 1 6   ? -43.284  23.928 18.727  1.00 30.22  ? -2   PHE A C   1 
ATOM   47   O O   . PHE A 1 6   ? -42.063  24.121 18.746  1.00 26.43  ? -2   PHE A O   1 
ATOM   48   C CB  . PHE A 1 6   ? -44.246  25.436 20.495  1.00 26.37  ? -2   PHE A CB  1 
ATOM   49   C CG  . PHE A 1 6   ? -44.970  25.541 21.798  1.00 28.09  ? -2   PHE A CG  1 
ATOM   50   C CD1 . PHE A 1 6   ? -46.353  25.584 21.828  1.00 26.60  ? -2   PHE A CD1 1 
ATOM   51   C CD2 . PHE A 1 6   ? -44.277  25.523 22.996  1.00 24.89  ? -2   PHE A CD2 1 
ATOM   52   C CE1 . PHE A 1 6   ? -47.031  25.653 23.026  1.00 27.28  ? -2   PHE A CE1 1 
ATOM   53   C CE2 . PHE A 1 6   ? -44.949  25.586 24.199  1.00 27.06  ? -2   PHE A CE2 1 
ATOM   54   C CZ  . PHE A 1 6   ? -46.329  25.652 24.215  1.00 27.57  ? -2   PHE A CZ  1 
ATOM   55   N N   . GLN A 1 7   ? -43.970  23.672 17.608  1.00 28.15  ? -1   GLN A N   1 
ATOM   56   C CA  . GLN A 1 7   ? -43.291  23.529 16.326  1.00 24.21  ? -1   GLN A CA  1 
ATOM   57   C C   . GLN A 1 7   ? -42.821  24.862 15.769  1.00 27.90  ? -1   GLN A C   1 
ATOM   58   O O   . GLN A 1 7   ? -41.949  24.881 14.893  1.00 31.31  ? -1   GLN A O   1 
ATOM   59   C CB  . GLN A 1 7   ? -44.206  22.866 15.289  1.00 30.86  ? -1   GLN A CB  1 
ATOM   60   C CG  . GLN A 1 7   ? -45.533  23.584 15.046  1.00 30.64  ? -1   GLN A CG  1 
ATOM   61   C CD  . GLN A 1 7   ? -46.351  22.936 13.937  1.00 36.09  ? -1   GLN A CD  1 
ATOM   62   O OE1 . GLN A 1 7   ? -45.928  22.903 12.781  1.00 36.91  ? -1   GLN A OE1 1 
ATOM   63   N NE2 . GLN A 1 7   ? -47.521  22.413 14.287  1.00 29.63  ? -1   GLN A NE2 1 
ATOM   64   N N   . SER A 1 8   ? -43.368  25.967 16.262  1.00 24.99  ? 858  SER A N   1 
ATOM   65   C CA  . SER A 1 8   ? -42.950  27.285 15.739  1.00 27.68  ? 858  SER A CA  1 
ATOM   66   C C   . SER A 1 8   ? -43.587  28.324 16.710  1.00 27.42  ? 858  SER A C   1 
ATOM   67   O O   . SER A 1 8   ? -44.516  28.054 17.478  1.00 28.86  ? 858  SER A O   1 
ATOM   68   C CB  . SER A 1 8   ? -43.578  27.455 14.351  1.00 32.30  ? 858  SER A CB  1 
ATOM   69   O OG  . SER A 1 8   ? -44.985  27.495 14.384  1.00 45.53  ? 858  SER A OG  1 
ATOM   70   N N   . ALA A 1 9   ? -43.012  29.523 16.653  1.00 23.87  ? 859  ALA A N   1 
ATOM   71   C CA  . ALA A 1 9   ? -43.535  30.617 17.459  1.00 24.32  ? 859  ALA A CA  1 
ATOM   72   C C   . ALA A 1 9   ? -43.160  31.940 16.810  1.00 26.21  ? 859  ALA A C   1 
ATOM   73   O O   . ALA A 1 9   ? -42.261  32.012 15.969  1.00 27.25  ? 859  ALA A O   1 
ATOM   74   C CB  . ALA A 1 9   ? -43.030  30.551 18.906  1.00 25.64  ? 859  ALA A CB  1 
ATOM   75   N N   . ALA A 1 10  ? -43.861  32.990 17.225  1.00 24.62  ? 860  ALA A N   1 
ATOM   76   C CA  . ALA A 1 10  ? -43.610  34.329 16.714  1.00 26.42  ? 860  ALA A CA  1 
ATOM   77   C C   . ALA A 1 10  ? -44.057  35.341 17.755  1.00 25.39  ? 860  ALA A C   1 
ATOM   78   O O   . ALA A 1 10  ? -44.971  35.078 18.534  1.00 26.91  ? 860  ALA A O   1 
ATOM   79   C CB  . ALA A 1 10  ? -44.329  34.573 15.381  1.00 25.91  ? 860  ALA A CB  1 
ATOM   80   N N   . ILE A 1 11  ? -43.377  36.481 17.803  1.00 24.55  ? 861  ILE A N   1 
ATOM   81   C CA  . ILE A 1 11  ? -43.735  37.551 18.726  1.00 24.51  ? 861  ILE A CA  1 
ATOM   82   C C   . ILE A 1 11  ? -44.024  38.812 17.923  1.00 28.42  ? 861  ILE A C   1 
ATOM   83   O O   . ILE A 1 11  ? -43.213  39.222 17.084  1.00 28.19  ? 861  ILE A O   1 
ATOM   84   C CB  . ILE A 1 11  ? -42.633  37.792 19.773  1.00 26.15  ? 861  ILE A CB  1 
ATOM   85   C CG1 . ILE A 1 11  ? -42.583  36.618 20.753  1.00 23.63  ? 861  ILE A CG1 1 
ATOM   86   C CG2 . ILE A 1 11  ? -42.896  39.078 20.537  1.00 27.72  ? 861  ILE A CG2 1 
ATOM   87   C CD1 . ILE A 1 11  ? -41.398  36.649 21.700  1.00 28.60  ? 861  ILE A CD1 1 
ATOM   88   N N   . TYR A 1 12  ? -45.177  39.422 18.187  1.00 27.53  ? 862  TYR A N   1 
ATOM   89   C CA  . TYR A 1 12  ? -45.641  40.622 17.502  1.00 25.82  ? 862  TYR A CA  1 
ATOM   90   C C   . TYR A 1 12  ? -45.641  41.752 18.522  1.00 27.09  ? 862  TYR A C   1 
ATOM   91   O O   . TYR A 1 12  ? -46.398  41.717 19.499  1.00 27.09  ? 862  TYR A O   1 
ATOM   92   C CB  . TYR A 1 12  ? -47.021  40.394 16.887  1.00 26.44  ? 862  TYR A CB  1 
ATOM   93   C CG  . TYR A 1 12  ? -46.992  39.251 15.900  1.00 26.40  ? 862  TYR A CG  1 
ATOM   94   C CD1 . TYR A 1 12  ? -47.142  37.938 16.328  1.00 25.05  ? 862  TYR A CD1 1 
ATOM   95   C CD2 . TYR A 1 12  ? -46.743  39.476 14.553  1.00 29.84  ? 862  TYR A CD2 1 
ATOM   96   C CE1 . TYR A 1 12  ? -47.085  36.885 15.437  1.00 23.41  ? 862  TYR A CE1 1 
ATOM   97   C CE2 . TYR A 1 12  ? -46.683  38.428 13.654  1.00 27.51  ? 862  TYR A CE2 1 
ATOM   98   C CZ  . TYR A 1 12  ? -46.854  37.135 14.101  1.00 23.84  ? 862  TYR A CZ  1 
ATOM   99   O OH  . TYR A 1 12  ? -46.794  36.090 13.207  1.00 27.11  ? 862  TYR A OH  1 
ATOM   100  N N   . ASN A 1 13  ? -44.747  42.715 18.328  1.00 31.80  ? 863  ASN A N   1 
ATOM   101  C CA  . ASN A 1 13  ? -44.621  43.869 19.210  1.00 29.59  ? 863  ASN A CA  1 
ATOM   102  C C   . ASN A 1 13  ? -45.494  44.990 18.638  1.00 32.61  ? 863  ASN A C   1 
ATOM   103  O O   . ASN A 1 13  ? -45.219  45.502 17.550  1.00 42.30  ? 863  ASN A O   1 
ATOM   104  C CB  . ASN A 1 13  ? -43.156  44.291 19.322  1.00 34.29  ? 863  ASN A CB  1 
ATOM   105  C CG  . ASN A 1 13  ? -42.316  43.318 20.157  1.00 39.10  ? 863  ASN A CG  1 
ATOM   106  O OD1 . ASN A 1 13  ? -42.777  42.772 21.155  1.00 39.05  ? 863  ASN A OD1 1 
ATOM   107  N ND2 . ASN A 1 13  ? -41.071  43.104 19.741  1.00 45.44  ? 863  ASN A ND2 1 
ATOM   108  N N   . ILE A 1 14  ? -46.566  45.341 19.344  1.00 39.46  ? 864  ILE A N   1 
ATOM   109  C CA  . ILE A 1 14  ? -47.604  46.244 18.859  1.00 44.40  ? 864  ILE A CA  1 
ATOM   110  C C   . ILE A 1 14  ? -47.362  47.623 19.454  1.00 36.79  ? 864  ILE A C   1 
ATOM   111  O O   . ILE A 1 14  ? -47.355  47.790 20.682  1.00 42.02  ? 864  ILE A O   1 
ATOM   112  C CB  . ILE A 1 14  ? -49.006  45.751 19.250  1.00 43.23  ? 864  ILE A CB  1 
ATOM   113  C CG1 . ILE A 1 14  ? -49.204  44.259 18.956  1.00 46.35  ? 864  ILE A CG1 1 
ATOM   114  C CG2 . ILE A 1 14  ? -50.081  46.631 18.626  1.00 41.54  ? 864  ILE A CG2 1 
ATOM   115  C CD1 . ILE A 1 14  ? -49.389  43.930 17.504  1.00 38.83  ? 864  ILE A CD1 1 
ATOM   116  N N   . ASP A 1 15  ? -47.191  48.598 18.564  1.00 44.89  ? 865  ASP A N   1 
ATOM   117  C CA  . ASP A 1 15  ? -47.034  50.026 18.940  1.00 42.13  ? 865  ASP A CA  1 
ATOM   118  C C   . ASP A 1 15  ? -48.154  50.865 18.297  1.00 39.99  ? 865  ASP A C   1 
ATOM   119  O O   . ASP A 1 15  ? -48.229  50.872 17.084  1.00 43.56  ? 865  ASP A O   1 
ATOM   120  C CB  . ASP A 1 15  ? -45.678  50.559 18.502  1.00 43.03  ? 865  ASP A CB  1 
ATOM   121  C CG  . ASP A 1 15  ? -45.445  52.012 18.863  1.00 52.15  ? 865  ASP A CG  1 
ATOM   122  O OD1 . ASP A 1 15  ? -46.247  52.564 19.630  1.00 54.46  ? 865  ASP A OD1 1 
ATOM   123  O OD2 . ASP A 1 15  ? -44.477  52.578 18.350  1.00 64.32  ? 865  ASP A OD2 1 
ATOM   124  N N   . THR A 1 16  ? -48.953  51.554 19.099  1.00 41.16  ? 866  THR A N   1 
ATOM   125  C CA  . THR A 1 16  ? -50.125  52.324 18.617  1.00 42.24  ? 866  THR A CA  1 
ATOM   126  C C   . THR A 1 16  ? -49.804  53.802 18.405  1.00 46.82  ? 866  THR A C   1 
ATOM   127  O O   . THR A 1 16  ? -50.740  54.574 18.245  1.00 46.49  ? 866  THR A O   1 
ATOM   128  C CB  . THR A 1 16  ? -51.271  52.179 19.611  1.00 45.66  ? 866  THR A CB  1 
ATOM   129  O OG1 . THR A 1 16  ? -50.893  52.666 20.897  1.00 50.86  ? 866  THR A OG1 1 
ATOM   130  C CG2 . THR A 1 16  ? -51.735  50.744 19.728  1.00 43.87  ? 866  THR A CG2 1 
ATOM   131  N N   . SER A 1 17  ? -48.526  54.150 18.354  1.00 49.43  ? 867  SER A N   1 
ATOM   132  C CA  . SER A 1 17  ? -48.090  55.547 18.156  1.00 53.33  ? 867  SER A CA  1 
ATOM   133  C C   . SER A 1 17  ? -48.503  56.055 16.778  1.00 53.18  ? 867  SER A C   1 
ATOM   134  O O   . SER A 1 17  ? -48.681  55.237 15.889  1.00 49.44  ? 867  SER A O   1 
ATOM   135  C CB  . SER A 1 17  ? -46.604  55.669 18.361  1.00 50.97  ? 867  SER A CB  1 
ATOM   136  O OG  . SER A 1 17  ? -45.912  55.583 17.129  1.00 61.71  ? 867  SER A OG  1 
ATOM   137  N N   . SER A 1 18  ? -48.537  57.375 16.611  1.00 57.55  ? 868  SER A N   1 
ATOM   138  C CA  . SER A 1 18  ? -49.028  58.025 15.370  1.00 55.11  ? 868  SER A CA  1 
ATOM   139  C C   . SER A 1 18  ? -48.360  57.509 14.099  1.00 57.99  ? 868  SER A C   1 
ATOM   140  O O   . SER A 1 18  ? -49.050  57.349 13.105  1.00 58.68  ? 868  SER A O   1 
ATOM   141  C CB  . SER A 1 18  ? -48.841  59.504 15.497  1.00 59.32  ? 868  SER A CB  1 
ATOM   142  O OG  . SER A 1 18  ? -47.469  59.848 15.417  1.00 68.91  ? 868  SER A OG  1 
ATOM   143  N N   . GLU A 1 19  ? -47.068  57.273 14.130  1.00 54.85  ? 869  GLU A N   1 
ATOM   144  C CA  . GLU A 1 19  ? -46.375  56.881 12.881  1.00 57.94  ? 869  GLU A CA  1 
ATOM   145  C C   . GLU A 1 19  ? -46.357  55.357 12.706  1.00 60.07  ? 869  GLU A C   1 
ATOM   146  O O   . GLU A 1 19  ? -45.942  54.907 11.633  1.00 56.96  ? 869  GLU A O   1 
ATOM   147  C CB  . GLU A 1 19  ? -44.952  57.427 12.917  1.00 62.97  ? 869  GLU A CB  1 
ATOM   148  C CG  . GLU A 1 19  ? -44.083  56.754 13.962  1.00 72.56  ? 869  GLU A CG  1 
ATOM   149  C CD  . GLU A 1 19  ? -43.266  55.576 13.459  1.00 81.29  ? 869  GLU A CD  1 
ATOM   150  O OE1 . GLU A 1 19  ? -42.406  55.788 12.587  1.00 82.02  ? 869  GLU A OE1 1 
ATOM   151  O OE2 . GLU A 1 19  ? -43.491  54.450 13.941  1.00 83.13  ? 869  GLU A OE2 1 
ATOM   152  N N   . SER A 1 20  ? -46.813  54.606 13.711  1.00 58.05  ? 870  SER A N   1 
ATOM   153  C CA  . SER A 1 20  ? -46.856  53.127 13.573  1.00 50.55  ? 870  SER A CA  1 
ATOM   154  C C   . SER A 1 20  ? -47.919  52.681 12.574  1.00 47.82  ? 870  SER A C   1 
ATOM   155  O O   . SER A 1 20  ? -48.992  53.260 12.548  1.00 51.24  ? 870  SER A O   1 
ATOM   156  C CB  . SER A 1 20  ? -47.073  52.448 14.882  1.00 48.09  ? 870  SER A CB  1 
ATOM   157  O OG  . SER A 1 20  ? -47.193  51.048 14.707  1.00 47.38  ? 870  SER A OG  1 
ATOM   158  N N   . PRO A 1 21  ? -47.657  51.630 11.796  1.00 42.85  ? 871  PRO A N   1 
ATOM   159  C CA  . PRO A 1 21  ? -48.672  51.065 10.923  1.00 46.26  ? 871  PRO A CA  1 
ATOM   160  C C   . PRO A 1 21  ? -49.840  50.487 11.742  1.00 45.06  ? 871  PRO A C   1 
ATOM   161  O O   . PRO A 1 21  ? -50.837  50.207 11.176  1.00 46.12  ? 871  PRO A O   1 
ATOM   162  C CB  . PRO A 1 21  ? -47.893  49.958 10.216  1.00 48.31  ? 871  PRO A CB  1 
ATOM   163  C CG  . PRO A 1 21  ? -46.768  49.616 11.141  1.00 47.33  ? 871  PRO A CG  1 
ATOM   164  C CD  . PRO A 1 21  ? -46.373  50.946 11.731  1.00 48.16  ? 871  PRO A CD  1 
ATOM   165  N N   . ASP A 1 22  ? -49.664  50.337 13.044  1.00 39.75  ? 872  ASP A N   1 
ATOM   166  C CA  . ASP A 1 22  ? -50.715  49.782 13.928  1.00 37.10  ? 872  ASP A CA  1 
ATOM   167  C C   . ASP A 1 22  ? -51.412  50.905 14.699  1.00 35.82  ? 872  ASP A C   1 
ATOM   168  O O   . ASP A 1 22  ? -52.155  50.600 15.619  1.00 32.95  ? 872  ASP A O   1 
ATOM   169  C CB  . ASP A 1 22  ? -50.123  48.697 14.821  1.00 38.90  ? 872  ASP A CB  1 
ATOM   170  C CG  . ASP A 1 22  ? -49.598  47.512 14.034  1.00 42.79  ? 872  ASP A CG  1 
ATOM   171  O OD1 . ASP A 1 22  ? -50.355  46.971 13.218  1.00 50.85  ? 872  ASP A OD1 1 
ATOM   172  O OD2 . ASP A 1 22  ? -48.446  47.143 14.247  1.00 45.69  ? 872  ASP A OD2 1 
ATOM   173  N N   . HIS A 1 23  ? -51.177  52.148 14.300  1.00 35.14  ? 873  HIS A N   1 
ATOM   174  C CA  . HIS A 1 23  ? -51.875  53.258 14.935  1.00 38.43  ? 873  HIS A CA  1 
ATOM   175  C C   . HIS A 1 23  ? -53.385  53.087 14.866  1.00 33.69  ? 873  HIS A C   1 
ATOM   176  O O   . HIS A 1 23  ? -54.093  53.479 15.802  1.00 34.69  ? 873  HIS A O   1 
ATOM   177  C CB  . HIS A 1 23  ? -51.477  54.575 14.271  1.00 42.82  ? 873  HIS A CB  1 
ATOM   178  C CG  . HIS A 1 23  ? -52.194  55.764 14.826  1.00 43.55  ? 873  HIS A CG  1 
ATOM   179  N ND1 . HIS A 1 23  ? -52.250  56.035 16.176  1.00 45.84  ? 873  HIS A ND1 1 
ATOM   180  C CD2 . HIS A 1 23  ? -52.927  56.726 14.219  1.00 39.84  ? 873  HIS A CD2 1 
ATOM   181  C CE1 . HIS A 1 23  ? -52.962  57.129 16.374  1.00 48.56  ? 873  HIS A CE1 1 
ATOM   182  N NE2 . HIS A 1 23  ? -53.386  57.567 15.202  1.00 44.61  ? 873  HIS A NE2 1 
ATOM   183  N N   . TYR A 1 24  ? -53.890  52.480 13.784  1.00 33.79  ? 874  TYR A N   1 
ATOM   184  C CA  . TYR A 1 24  ? -55.332  52.331 13.596  1.00 34.57  ? 874  TYR A CA  1 
ATOM   185  C C   . TYR A 1 24  ? -56.002  51.678 14.799  1.00 32.86  ? 874  TYR A C   1 
ATOM   186  O O   . TYR A 1 24  ? -57.188  51.924 15.069  1.00 35.35  ? 874  TYR A O   1 
ATOM   187  C CB  . TYR A 1 24  ? -55.618  51.520 12.323  1.00 31.85  ? 874  TYR A CB  1 
ATOM   188  C CG  . TYR A 1 24  ? -55.357  50.027 12.437  1.00 34.98  ? 874  TYR A CG  1 
ATOM   189  C CD1 . TYR A 1 24  ? -54.071  49.509 12.321  1.00 31.08  ? 874  TYR A CD1 1 
ATOM   190  C CD2 . TYR A 1 24  ? -56.400  49.136 12.664  1.00 29.25  ? 874  TYR A CD2 1 
ATOM   191  C CE1 . TYR A 1 24  ? -53.835  48.144 12.426  1.00 31.91  ? 874  TYR A CE1 1 
ATOM   192  C CE2 . TYR A 1 24  ? -56.173  47.775 12.773  1.00 30.20  ? 874  TYR A CE2 1 
ATOM   193  C CZ  . TYR A 1 24  ? -54.890  47.284 12.654  1.00 32.72  ? 874  TYR A CZ  1 
ATOM   194  O OH  . TYR A 1 24  ? -54.667  45.929 12.763  1.00 31.37  ? 874  TYR A OH  1 
ATOM   195  N N   . LEU A 1 25  ? -55.246  50.889 15.565  1.00 29.57  ? 875  LEU A N   1 
ATOM   196  C CA  . LEU A 1 25  ? -55.811  50.182 16.706  1.00 29.01  ? 875  LEU A CA  1 
ATOM   197  C C   . LEU A 1 25  ? -56.359  51.123 17.772  1.00 30.48  ? 875  LEU A C   1 
ATOM   198  O O   . LEU A 1 25  ? -57.206  50.702 18.567  1.00 31.66  ? 875  LEU A O   1 
ATOM   199  C CB  . LEU A 1 25  ? -54.755  49.255 17.311  1.00 28.75  ? 875  LEU A CB  1 
ATOM   200  C CG  . LEU A 1 25  ? -54.358  48.070 16.427  1.00 32.22  ? 875  LEU A CG  1 
ATOM   201  C CD1 . LEU A 1 25  ? -53.202  47.298 17.034  1.00 32.04  ? 875  LEU A CD1 1 
ATOM   202  C CD2 . LEU A 1 25  ? -55.552  47.154 16.207  1.00 32.67  ? 875  LEU A CD2 1 
ATOM   203  N N   . VAL A 1 26  ? -55.919  52.385 17.808  1.00 33.76  ? 876  VAL A N   1 
ATOM   204  C CA  . VAL A 1 26  ? -56.450  53.304 18.811  1.00 37.67  ? 876  VAL A CA  1 
ATOM   205  C C   . VAL A 1 26  ? -57.928  53.593 18.605  1.00 37.53  ? 876  VAL A C   1 
ATOM   206  O O   . VAL A 1 26  ? -58.575  54.129 19.512  1.00 37.41  ? 876  VAL A O   1 
ATOM   207  C CB  . VAL A 1 26  ? -55.683  54.643 18.845  1.00 41.41  ? 876  VAL A CB  1 
ATOM   208  C CG1 . VAL A 1 26  ? -54.207  54.406 19.132  1.00 40.97  ? 876  VAL A CG1 1 
ATOM   209  C CG2 . VAL A 1 26  ? -55.896  55.430 17.559  1.00 38.02  ? 876  VAL A CG2 1 
ATOM   210  N N   . ASP A 1 27  ? -58.483  53.238 17.446  1.00 38.22  ? 877  ASP A N   1 
ATOM   211  C CA  . ASP A 1 27  ? -59.887  53.501 17.164  1.00 35.75  ? 877  ASP A CA  1 
ATOM   212  C C   . ASP A 1 27  ? -60.807  52.360 17.578  1.00 33.59  ? 877  ASP A C   1 
ATOM   213  O O   . ASP A 1 27  ? -61.986  52.365 17.212  1.00 34.81  ? 877  ASP A O   1 
ATOM   214  C CB  . ASP A 1 27  ? -60.072  53.809 15.678  1.00 33.48  ? 877  ASP A CB  1 
ATOM   215  C CG  . ASP A 1 27  ? -59.663  55.223 15.330  1.00 37.60  ? 877  ASP A CG  1 
ATOM   216  O OD1 . ASP A 1 27  ? -59.505  56.036 16.264  1.00 35.44  ? 877  ASP A OD1 1 
ATOM   217  O OD2 . ASP A 1 27  ? -59.492  55.521 14.129  1.00 35.95  ? 877  ASP A OD2 1 
ATOM   218  N N   . HIS A 1 28  ? -60.314  51.399 18.349  1.00 32.02  ? 878  HIS A N   1 
ATOM   219  C CA  . HIS A 1 28  ? -61.131  50.283 18.810  1.00 31.95  ? 878  HIS A CA  1 
ATOM   220  C C   . HIS A 1 28  ? -61.287  50.405 20.324  1.00 39.34  ? 878  HIS A C   1 
ATOM   221  O O   . HIS A 1 28  ? -60.547  49.785 21.091  1.00 36.96  ? 878  HIS A O   1 
ATOM   222  C CB  . HIS A 1 28  ? -60.455  48.946 18.374  1.00 31.12  ? 878  HIS A CB  1 
ATOM   223  C CG  . HIS A 1 28  ? -61.271  47.722 18.650  1.00 29.95  ? 878  HIS A CG  1 
ATOM   224  N ND1 . HIS A 1 28  ? -61.097  46.950 19.778  1.00 30.04  ? 878  HIS A ND1 1 
ATOM   225  C CD2 . HIS A 1 28  ? -62.261  47.132 17.939  1.00 28.16  ? 878  HIS A CD2 1 
ATOM   226  C CE1 . HIS A 1 28  ? -61.946  45.938 19.751  1.00 31.62  ? 878  HIS A CE1 1 
ATOM   227  N NE2 . HIS A 1 28  ? -62.666  46.027 18.648  1.00 29.27  ? 878  HIS A NE2 1 
ATOM   228  N N   . THR A 1 29  ? -62.266  51.207 20.768  1.00 38.11  ? 879  THR A N   1 
ATOM   229  C CA  . THR A 1 29  ? -62.439  51.479 22.187  1.00 35.55  ? 879  THR A CA  1 
ATOM   230  C C   . THR A 1 29  ? -63.755  50.878 22.656  1.00 40.62  ? 879  THR A C   1 
ATOM   231  O O   . THR A 1 29  ? -64.814  51.220 22.134  1.00 43.63  ? 879  THR A O   1 
ATOM   232  C CB  . THR A 1 29  ? -62.425  52.990 22.431  1.00 37.95  ? 879  THR A CB  1 
ATOM   233  O OG1 . THR A 1 29  ? -61.163  53.532 22.017  1.00 38.29  ? 879  THR A OG1 1 
ATOM   234  C CG2 . THR A 1 29  ? -62.683  53.316 23.890  1.00 44.04  ? 879  THR A CG2 1 
ATOM   235  N N   . LEU A 1 30  ? -63.702  50.075 23.714  1.00 33.87  ? 880  LEU A N   1 
ATOM   236  C CA  . LEU A 1 30  ? -64.872  49.392 24.261  1.00 37.82  ? 880  LEU A CA  1 
ATOM   237  C C   . LEU A 1 30  ? -64.944  49.676 25.748  1.00 45.24  ? 880  LEU A C   1 
ATOM   238  O O   . LEU A 1 30  ? -63.989  49.400 26.479  1.00 39.74  ? 880  LEU A O   1 
ATOM   239  C CB  . LEU A 1 30  ? -64.828  47.879 24.001  1.00 41.43  ? 880  LEU A CB  1 
ATOM   240  C CG  . LEU A 1 30  ? -64.451  47.409 22.595  1.00 42.63  ? 880  LEU A CG  1 
ATOM   241  C CD1 . LEU A 1 30  ? -64.794  45.960 22.397  1.00 47.22  ? 880  LEU A CD1 1 
ATOM   242  C CD2 . LEU A 1 30  ? -65.227  48.207 21.570  1.00 40.77  ? 880  LEU A CD2 1 
ATOM   243  N N   . ASP A 1 31  ? -66.036  50.310 26.173  1.00 44.64  ? 881  ASP A N   1 
ATOM   244  C CA  . ASP A 1 31  ? -66.224  50.709 27.568  1.00 43.97  ? 881  ASP A CA  1 
ATOM   245  C C   . ASP A 1 31  ? -65.056  51.566 28.048  1.00 44.87  ? 881  ASP A C   1 
ATOM   246  O O   . ASP A 1 31  ? -64.524  51.376 29.144  1.00 46.50  ? 881  ASP A O   1 
ATOM   247  C CB  . ASP A 1 31  ? -66.411  49.496 28.484  1.00 50.43  ? 881  ASP A CB  1 
ATOM   248  C CG  . ASP A 1 31  ? -67.271  49.806 29.700  1.00 54.60  ? 881  ASP A CG  1 
ATOM   249  O OD1 . ASP A 1 31  ? -67.854  50.907 29.756  1.00 49.67  ? 881  ASP A OD1 1 
ATOM   250  O OD2 . ASP A 1 31  ? -67.337  48.958 30.615  1.00 54.46  ? 881  ASP A OD2 1 
ATOM   251  N N   . GLY A 1 32  ? -64.652  52.515 27.206  1.00 39.49  ? 882  GLY A N   1 
ATOM   252  C CA  . GLY A 1 32  ? -63.605  53.472 27.508  1.00 41.04  ? 882  GLY A CA  1 
ATOM   253  C C   . GLY A 1 32  ? -62.184  52.956 27.561  1.00 45.38  ? 882  GLY A C   1 
ATOM   254  O O   . GLY A 1 32  ? -61.286  53.734 27.908  1.00 44.74  ? 882  GLY A O   1 
ATOM   255  N N   . ARG A 1 33  ? -61.928  51.721 27.130  1.00 39.44  ? 883  ARG A N   1 
ATOM   256  C CA  . ARG A 1 33  ? -60.577  51.180 27.063  1.00 41.55  ? 883  ARG A CA  1 
ATOM   257  C C   . ARG A 1 33  ? -60.235  50.798 25.631  1.00 42.83  ? 883  ARG A C   1 
ATOM   258  O O   . ARG A 1 33  ? -61.089  50.296 24.894  1.00 37.15  ? 883  ARG A O   1 
ATOM   259  C CB  . ARG A 1 33  ? -60.444  49.936 27.959  1.00 41.53  ? 883  ARG A CB  1 
ATOM   260  C CG  . ARG A 1 33  ? -60.675  50.164 29.440  1.00 48.60  ? 883  ARG A CG  1 
ATOM   261  C CD  . ARG A 1 33  ? -60.586  48.843 30.192  1.00 51.06  ? 883  ARG A CD  1 
ATOM   262  N NE  . ARG A 1 33  ? -61.449  47.805 29.639  1.00 53.93  ? 883  ARG A NE  1 
ATOM   263  C CZ  . ARG A 1 33  ? -61.413  46.529 30.002  1.00 59.57  ? 883  ARG A CZ  1 
ATOM   264  N NH1 . ARG A 1 33  ? -60.428  46.047 30.739  1.00 60.04  ? 883  ARG A NH1 1 
ATOM   265  N NH2 . ARG A 1 33  ? -62.383  45.712 29.597  1.00 59.67  ? 883  ARG A NH2 1 
ATOM   266  N N   . VAL A 1 34  ? -58.971  50.989 25.260  1.00 37.46  ? 884  VAL A N   1 
ATOM   267  C CA  . VAL A 1 34  ? -58.471  50.540 23.964  1.00 39.76  ? 884  VAL A CA  1 
ATOM   268  C C   . VAL A 1 34  ? -58.131  49.058 24.077  1.00 36.40  ? 884  VAL A C   1 
ATOM   269  O O   . VAL A 1 34  ? -57.138  48.684 24.704  1.00 37.59  ? 884  VAL A O   1 
ATOM   270  C CB  . VAL A 1 34  ? -57.257  51.362 23.513  1.00 40.66  ? 884  VAL A CB  1 
ATOM   271  C CG1 . VAL A 1 34  ? -56.735  50.865 22.165  1.00 39.63  ? 884  VAL A CG1 1 
ATOM   272  C CG2 . VAL A 1 34  ? -57.608  52.841 23.450  1.00 48.44  ? 884  VAL A CG2 1 
ATOM   273  N N   . LEU A 1 35  ? -58.941  48.218 23.445  1.00 33.47  ? 885  LEU A N   1 
ATOM   274  C CA  . LEU A 1 35  ? -58.807  46.769 23.505  1.00 29.70  ? 885  LEU A CA  1 
ATOM   275  C C   . LEU A 1 35  ? -58.222  46.255 22.200  1.00 31.64  ? 885  LEU A C   1 
ATOM   276  O O   . LEU A 1 35  ? -58.653  46.673 21.122  1.00 29.28  ? 885  LEU A O   1 
ATOM   277  C CB  . LEU A 1 35  ? -60.155  46.092 23.762  1.00 35.66  ? 885  LEU A CB  1 
ATOM   278  C CG  . LEU A 1 35  ? -60.785  46.272 25.140  1.00 41.82  ? 885  LEU A CG  1 
ATOM   279  C CD1 . LEU A 1 35  ? -62.049  45.448 25.289  1.00 41.11  ? 885  LEU A CD1 1 
ATOM   280  C CD2 . LEU A 1 35  ? -59.793  45.846 26.155  1.00 48.08  ? 885  LEU A CD2 1 
ATOM   281  N N   . PHE A 1 36  ? -57.203  45.412 22.291  1.00 30.96  ? 886  PHE A N   1 
ATOM   282  C CA  . PHE A 1 36  ? -56.744  44.730 21.093  1.00 29.81  ? 886  PHE A CA  1 
ATOM   283  C C   . PHE A 1 36  ? -57.894  43.870 20.574  1.00 28.98  ? 886  PHE A C   1 
ATOM   284  O O   . PHE A 1 36  ? -58.475  43.091 21.344  1.00 29.09  ? 886  PHE A O   1 
ATOM   285  C CB  . PHE A 1 36  ? -55.514  43.868 21.377  1.00 29.48  ? 886  PHE A CB  1 
ATOM   286  C CG  . PHE A 1 36  ? -54.819  43.365 20.135  1.00 30.14  ? 886  PHE A CG  1 
ATOM   287  C CD1 . PHE A 1 36  ? -54.012  44.210 19.391  1.00 34.17  ? 886  PHE A CD1 1 
ATOM   288  C CD2 . PHE A 1 36  ? -54.952  42.047 19.728  1.00 28.25  ? 886  PHE A CD2 1 
ATOM   289  C CE1 . PHE A 1 36  ? -53.362  43.755 18.256  1.00 30.89  ? 886  PHE A CE1 1 
ATOM   290  C CE2 . PHE A 1 36  ? -54.301  41.586 18.594  1.00 28.28  ? 886  PHE A CE2 1 
ATOM   291  C CZ  . PHE A 1 36  ? -53.507  42.442 17.858  1.00 28.99  ? 886  PHE A CZ  1 
ATOM   292  N N   . PRO A 1 37  ? -58.273  43.997 19.307  1.00 30.89  ? 887  PRO A N   1 
ATOM   293  C CA  . PRO A 1 37  ? -59.468  43.295 18.826  1.00 26.41  ? 887  PRO A CA  1 
ATOM   294  C C   . PRO A 1 37  ? -59.237  41.799 18.680  1.00 24.05  ? 887  PRO A C   1 
ATOM   295  O O   . PRO A 1 37  ? -58.130  41.340 18.391  1.00 30.79  ? 887  PRO A O   1 
ATOM   296  C CB  . PRO A 1 37  ? -59.747  43.946 17.465  1.00 28.00  ? 887  PRO A CB  1 
ATOM   297  C CG  . PRO A 1 37  ? -58.469  44.582 17.052  1.00 29.33  ? 887  PRO A CG  1 
ATOM   298  C CD  . PRO A 1 37  ? -57.650  44.847 18.278  1.00 28.72  ? 887  PRO A CD  1 
ATOM   299  N N   . ALA A 1 38  ? -60.310  41.036 18.914  1.00 29.63  ? 888  ALA A N   1 
ATOM   300  C CA  . ALA A 1 38  ? -60.288  39.593 18.674  1.00 27.53  ? 888  ALA A CA  1 
ATOM   301  C C   . ALA A 1 38  ? -59.771  39.261 17.272  1.00 26.38  ? 888  ALA A C   1 
ATOM   302  O O   . ALA A 1 38  ? -58.975  38.319 17.078  1.00 30.60  ? 888  ALA A O   1 
ATOM   303  C CB  . ALA A 1 38  ? -61.700  39.032 18.870  1.00 28.21  ? 888  ALA A CB  1 
ATOM   304  N N   . THR A 1 39  ? -60.190  40.047 16.279  1.00 27.45  ? 889  THR A N   1 
ATOM   305  C CA  . THR A 1 39  ? -59.750  39.804 14.912  1.00 23.57  ? 889  THR A CA  1 
ATOM   306  C C   . THR A 1 39  ? -58.271  40.129 14.724  1.00 28.31  ? 889  THR A C   1 
ATOM   307  O O   . THR A 1 39  ? -57.637  39.596 13.803  1.00 28.14  ? 889  THR A O   1 
ATOM   308  C CB  . THR A 1 39  ? -60.610  40.613 13.938  1.00 25.50  ? 889  THR A CB  1 
ATOM   309  O OG1 . THR A 1 39  ? -60.519  42.006 14.259  1.00 27.00  ? 889  THR A OG1 1 
ATOM   310  C CG2 . THR A 1 39  ? -62.072  40.181 14.040  1.00 28.50  ? 889  THR A CG2 1 
ATOM   311  N N   . GLY A 1 40  ? -57.696  40.951 15.605  1.00 24.03  ? 890  GLY A N   1 
ATOM   312  C CA  . GLY A 1 40  ? -56.253  41.137 15.592  1.00 26.73  ? 890  GLY A CA  1 
ATOM   313  C C   . GLY A 1 40  ? -55.505  39.880 16.000  1.00 25.87  ? 890  GLY A C   1 
ATOM   314  O O   . GLY A 1 40  ? -54.429  39.574 15.461  1.00 27.34  ? 890  GLY A O   1 
ATOM   315  N N   . TYR A 1 41  ? -56.061  39.128 16.955  1.00 24.25  ? 891  TYR A N   1 
ATOM   316  C CA  . TYR A 1 41  ? -55.470  37.838 17.289  1.00 26.60  ? 891  TYR A CA  1 
ATOM   317  C C   . TYR A 1 41  ? -55.545  36.899 16.098  1.00 29.09  ? 891  TYR A C   1 
ATOM   318  O O   . TYR A 1 41  ? -54.582  36.172 15.808  1.00 23.61  ? 891  TYR A O   1 
ATOM   319  C CB  . TYR A 1 41  ? -56.166  37.204 18.491  1.00 25.91  ? 891  TYR A CB  1 
ATOM   320  C CG  . TYR A 1 41  ? -56.147  38.030 19.751  1.00 25.33  ? 891  TYR A CG  1 
ATOM   321  C CD1 . TYR A 1 41  ? -54.953  38.451 20.330  1.00 27.81  ? 891  TYR A CD1 1 
ATOM   322  C CD2 . TYR A 1 41  ? -57.334  38.375 20.374  1.00 30.15  ? 891  TYR A CD2 1 
ATOM   323  C CE1 . TYR A 1 41  ? -54.956  39.207 21.496  1.00 27.54  ? 891  TYR A CE1 1 
ATOM   324  C CE2 . TYR A 1 41  ? -57.348  39.121 21.525  1.00 30.26  ? 891  TYR A CE2 1 
ATOM   325  C CZ  . TYR A 1 41  ? -56.165  39.537 22.084  1.00 31.04  ? 891  TYR A CZ  1 
ATOM   326  O OH  . TYR A 1 41  ? -56.216  40.282 23.237  1.00 31.32  ? 891  TYR A OH  1 
ATOM   327  N N   . LEU A 1 42  ? -56.694  36.882 15.407  1.00 27.04  ? 892  LEU A N   1 
ATOM   328  C CA  . LEU A 1 42  ? -56.765  36.061 14.197  1.00 27.96  ? 892  LEU A CA  1 
ATOM   329  C C   . LEU A 1 42  ? -55.668  36.435 13.208  1.00 26.93  ? 892  LEU A C   1 
ATOM   330  O O   . LEU A 1 42  ? -55.033  35.557 12.610  1.00 28.81  ? 892  LEU A O   1 
ATOM   331  C CB  . LEU A 1 42  ? -58.128  36.191 13.522  1.00 24.31  ? 892  LEU A CB  1 
ATOM   332  C CG  . LEU A 1 42  ? -59.363  35.875 14.354  1.00 26.86  ? 892  LEU A CG  1 
ATOM   333  C CD1 . LEU A 1 42  ? -60.609  36.133 13.523  1.00 28.90  ? 892  LEU A CD1 1 
ATOM   334  C CD2 . LEU A 1 42  ? -59.325  34.444 14.866  1.00 27.28  ? 892  LEU A CD2 1 
ATOM   335  N N   . SER A 1 43  ? -55.433  37.737 13.024  1.00 25.48  ? 893  SER A N   1 
ATOM   336  C CA  . SER A 1 43  ? -54.426  38.176 12.060  1.00 26.64  ? 893  SER A CA  1 
ATOM   337  C C   . SER A 1 43  ? -53.036  37.665 12.427  1.00 25.71  ? 893  SER A C   1 
ATOM   338  O O   . SER A 1 43  ? -52.316  37.132 11.572  1.00 25.91  ? 893  SER A O   1 
ATOM   339  C CB  . SER A 1 43  ? -54.424  39.697 11.953  1.00 27.42  ? 893  SER A CB  1 
ATOM   340  O OG  . SER A 1 43  ? -53.414  40.136 11.062  1.00 30.52  ? 893  SER A OG  1 
ATOM   341  N N   . ILE A 1 44  ? -52.628  37.835 13.689  1.00 25.30  ? 894  ILE A N   1 
ATOM   342  C CA  . ILE A 1 44  ? -51.254  37.435 14.012  1.00 24.92  ? 894  ILE A CA  1 
ATOM   343  C C   . ILE A 1 44  ? -51.100  35.911 14.021  1.00 25.31  ? 894  ILE A C   1 
ATOM   344  O O   . ILE A 1 44  ? -50.030  35.388 13.667  1.00 25.69  ? 894  ILE A O   1 
ATOM   345  C CB  . ILE A 1 44  ? -50.772  38.070 15.332  1.00 22.70  ? 894  ILE A CB  1 
ATOM   346  C CG1 . ILE A 1 44  ? -51.638  37.644 16.517  1.00 24.38  ? 894  ILE A CG1 1 
ATOM   347  C CG2 . ILE A 1 44  ? -50.688  39.586 15.200  1.00 25.37  ? 894  ILE A CG2 1 
ATOM   348  C CD1 . ILE A 1 44  ? -51.089  38.121 17.851  1.00 28.47  ? 894  ILE A CD1 1 
ATOM   349  N N   . VAL A 1 45  ? -52.156  35.165 14.364  1.00 23.57  ? 895  VAL A N   1 
ATOM   350  C CA  . VAL A 1 45  ? -52.070  33.708 14.250  1.00 25.52  ? 895  VAL A CA  1 
ATOM   351  C C   . VAL A 1 45  ? -51.941  33.290 12.787  1.00 27.75  ? 895  VAL A C   1 
ATOM   352  O O   . VAL A 1 45  ? -51.141  32.407 12.440  1.00 24.69  ? 895  VAL A O   1 
ATOM   353  C CB  . VAL A 1 45  ? -53.287  33.044 14.920  1.00 21.67  ? 895  VAL A CB  1 
ATOM   354  C CG1 . VAL A 1 45  ? -53.284  31.546 14.659  1.00 24.27  ? 895  VAL A CG1 1 
ATOM   355  C CG2 . VAL A 1 45  ? -53.281  33.318 16.410  1.00 27.99  ? 895  VAL A CG2 1 
ATOM   356  N N   . TRP A 1 46  ? -52.750  33.898 11.918  1.00 24.09  ? 896  TRP A N   1 
ATOM   357  C CA  . TRP A 1 46  ? -52.671  33.653 10.483  1.00 25.25  ? 896  TRP A CA  1 
ATOM   358  C C   . TRP A 1 46  ? -51.267  33.922 9.958   1.00 25.65  ? 896  TRP A C   1 
ATOM   359  O O   . TRP A 1 46  ? -50.720  33.130 9.181   1.00 26.76  ? 896  TRP A O   1 
ATOM   360  C CB  . TRP A 1 46  ? -53.699  34.549 9.797   1.00 25.42  ? 896  TRP A CB  1 
ATOM   361  C CG  . TRP A 1 46  ? -54.022  34.300 8.364   1.00 28.85  ? 896  TRP A CG  1 
ATOM   362  C CD1 . TRP A 1 46  ? -53.653  33.241 7.585   1.00 28.63  ? 896  TRP A CD1 1 
ATOM   363  C CD2 . TRP A 1 46  ? -54.821  35.149 7.540   1.00 27.12  ? 896  TRP A CD2 1 
ATOM   364  N NE1 . TRP A 1 46  ? -54.172  33.390 6.316   1.00 28.90  ? 896  TRP A NE1 1 
ATOM   365  C CE2 . TRP A 1 46  ? -54.893  34.555 6.267   1.00 32.34  ? 896  TRP A CE2 1 
ATOM   366  C CE3 . TRP A 1 46  ? -55.480  36.363 7.758   1.00 26.61  ? 896  TRP A CE3 1 
ATOM   367  C CZ2 . TRP A 1 46  ? -55.600  35.135 5.214   1.00 31.12  ? 896  TRP A CZ2 1 
ATOM   368  C CZ3 . TRP A 1 46  ? -56.178  36.936 6.718   1.00 30.02  ? 896  TRP A CZ3 1 
ATOM   369  C CH2 . TRP A 1 46  ? -56.235  36.323 5.461   1.00 27.65  ? 896  TRP A CH2 1 
ATOM   370  N N   . LYS A 1 47  ? -50.666  35.035 10.386  1.00 24.93  ? 897  LYS A N   1 
ATOM   371  C CA  . LYS A 1 47  ? -49.313  35.372 9.954   1.00 24.75  ? 897  LYS A CA  1 
ATOM   372  C C   . LYS A 1 47  ? -48.293  34.353 10.457  1.00 25.52  ? 897  LYS A C   1 
ATOM   373  O O   . LYS A 1 47  ? -47.318  34.044 9.755   1.00 27.22  ? 897  LYS A O   1 
ATOM   374  C CB  . LYS A 1 47  ? -48.967  36.783 10.433  1.00 26.62  ? 897  LYS A CB  1 
ATOM   375  C CG  . LYS A 1 47  ? -49.629  37.889 9.612   1.00 27.75  ? 897  LYS A CG  1 
ATOM   376  C CD  . LYS A 1 47  ? -49.236  39.267 10.115  1.00 33.96  ? 897  LYS A CD  1 
ATOM   377  C CE  . LYS A 1 47  ? -50.010  40.367 9.411   1.00 32.12  ? 897  LYS A CE  1 
ATOM   378  N NZ  . LYS A 1 47  ? -49.700  41.690 10.017  1.00 35.01  ? 897  LYS A NZ  1 
ATOM   379  N N   . THR A 1 48  ? -48.522  33.789 11.649  1.00 24.30  ? 898  THR A N   1 
ATOM   380  C CA  . THR A 1 48  ? -47.602  32.789 12.192  1.00 23.63  ? 898  THR A CA  1 
ATOM   381  C C   . THR A 1 48  ? -47.681  31.477 11.408  1.00 29.68  ? 898  THR A C   1 
ATOM   382  O O   . THR A 1 48  ? -46.650  30.857 11.096  1.00 26.45  ? 898  THR A O   1 
ATOM   383  C CB  . THR A 1 48  ? -47.922  32.561 13.671  1.00 24.69  ? 898  THR A CB  1 
ATOM   384  O OG1 . THR A 1 48  ? -47.902  33.819 14.359  1.00 21.94  ? 898  THR A OG1 1 
ATOM   385  C CG2 . THR A 1 48  ? -46.910  31.625 14.315  1.00 25.09  ? 898  THR A CG2 1 
ATOM   386  N N   . LEU A 1 49  ? -48.900  31.048 11.072  1.00 24.47  ? 899  LEU A N   1 
ATOM   387  C CA  . LEU A 1 49  ? -49.061  29.884 10.202  1.00 28.80  ? 899  LEU A CA  1 
ATOM   388  C C   . LEU A 1 49  ? -48.428  30.122 8.835   1.00 27.45  ? 899  LEU A C   1 
ATOM   389  O O   . LEU A 1 49  ? -47.756  29.235 8.288   1.00 30.13  ? 899  LEU A O   1 
ATOM   390  C CB  . LEU A 1 49  ? -50.541  29.534 10.052  1.00 25.48  ? 899  LEU A CB  1 
ATOM   391  C CG  . LEU A 1 49  ? -50.846  28.343 9.137   1.00 30.84  ? 899  LEU A CG  1 
ATOM   392  C CD1 . LEU A 1 49  ? -50.290  27.042 9.700   1.00 28.13  ? 899  LEU A CD1 1 
ATOM   393  C CD2 . LEU A 1 49  ? -52.344  28.229 8.883   1.00 30.84  ? 899  LEU A CD2 1 
ATOM   394  N N   . ALA A 1 50  ? -48.636  31.313 8.265   1.00 29.17  ? 900  ALA A N   1 
ATOM   395  C CA  . ALA A 1 50  ? -48.033  31.625 6.974   1.00 28.83  ? 900  ALA A CA  1 
ATOM   396  C C   . ALA A 1 50  ? -46.519  31.500 7.033   1.00 30.80  ? 900  ALA A C   1 
ATOM   397  O O   . ALA A 1 50  ? -45.900  30.924 6.130   1.00 31.57  ? 900  ALA A O   1 
ATOM   398  C CB  . ALA A 1 50  ? -48.433  33.031 6.530   1.00 30.52  ? 900  ALA A CB  1 
ATOM   399  N N   . ARG A 1 51  ? -45.907  32.020 8.101   1.00 27.43  ? 901  ARG A N   1 
ATOM   400  C CA  . ARG A 1 51  ? -44.460  31.896 8.255   1.00 31.45  ? 901  ARG A CA  1 
ATOM   401  C C   . ARG A 1 51  ? -44.035  30.435 8.330   1.00 32.49  ? 901  ARG A C   1 
ATOM   402  O O   . ARG A 1 51  ? -43.033  30.040 7.721   1.00 33.56  ? 901  ARG A O   1 
ATOM   403  C CB  . ARG A 1 51  ? -43.997  32.653 9.498   1.00 29.06  ? 901  ARG A CB  1 
ATOM   404  C CG  . ARG A 1 51  ? -42.491  32.883 9.572   1.00 30.50  ? 901  ARG A CG  1 
ATOM   405  C CD  . ARG A 1 51  ? -42.057  33.933 8.554   1.00 32.10  ? 901  ARG A CD  1 
ATOM   406  N NE  . ARG A 1 51  ? -40.628  34.223 8.609   1.00 32.15  ? 901  ARG A NE  1 
ATOM   407  C CZ  . ARG A 1 51  ? -40.054  35.265 8.022   1.00 36.89  ? 901  ARG A CZ  1 
ATOM   408  N NH1 . ARG A 1 51  ? -40.756  36.128 7.305   1.00 31.37  ? 901  ARG A NH1 1 
ATOM   409  N NH2 . ARG A 1 51  ? -38.744  35.450 8.163   1.00 32.41  ? 901  ARG A NH2 1 
ATOM   410  N N   . ALA A 1 52  ? -44.776  29.619 9.089   1.00 27.93  ? 902  ALA A N   1 
ATOM   411  C CA  . ALA A 1 52  ? -44.412  28.208 9.208   1.00 31.08  ? 902  ALA A CA  1 
ATOM   412  C C   . ALA A 1 52  ? -44.531  27.474 7.877   1.00 40.20  ? 902  ALA A C   1 
ATOM   413  O O   . ALA A 1 52  ? -43.809  26.497 7.641   1.00 39.18  ? 902  ALA A O   1 
ATOM   414  C CB  . ALA A 1 52  ? -45.276  27.525 10.265  1.00 31.76  ? 902  ALA A CB  1 
ATOM   415  N N   . LEU A 1 53  ? -45.431  27.918 7.002   1.00 34.60  ? 903  LEU A N   1 
ATOM   416  C CA  . LEU A 1 53  ? -45.627  27.252 5.721   1.00 37.28  ? 903  LEU A CA  1 
ATOM   417  C C   . LEU A 1 53  ? -44.810  27.886 4.601   1.00 38.58  ? 903  LEU A C   1 
ATOM   418  O O   . LEU A 1 53  ? -44.766  27.334 3.496   1.00 42.97  ? 903  LEU A O   1 
ATOM   419  C CB  . LEU A 1 53  ? -47.114  27.275 5.348   1.00 38.70  ? 903  LEU A CB  1 
ATOM   420  C CG  . LEU A 1 53  ? -48.020  26.438 6.259   1.00 37.12  ? 903  LEU A CG  1 
ATOM   421  C CD1 . LEU A 1 53  ? -49.501  26.621 5.917   1.00 38.12  ? 903  LEU A CD1 1 
ATOM   422  C CD2 . LEU A 1 53  ? -47.625  24.966 6.249   1.00 41.16  ? 903  LEU A CD2 1 
ATOM   423  N N   . GLY A 1 54  ? -44.119  28.990 4.878   1.00 38.25  ? 904  GLY A N   1 
ATOM   424  C CA  . GLY A 1 54  ? -43.384  29.708 3.853   1.00 40.16  ? 904  GLY A CA  1 
ATOM   425  C C   . GLY A 1 54  ? -44.240  30.427 2.831   1.00 48.91  ? 904  GLY A C   1 
ATOM   426  O O   . GLY A 1 54  ? -43.818  30.580 1.681   1.00 43.53  ? 904  GLY A O   1 
ATOM   427  N N   . LEU A 1 55  ? -45.420  30.903 3.225   1.00 38.62  ? 905  LEU A N   1 
ATOM   428  C CA  . LEU A 1 55  ? -46.370  31.525 2.315   1.00 39.61  ? 905  LEU A CA  1 
ATOM   429  C C   . LEU A 1 55  ? -46.633  32.964 2.728   1.00 41.31  ? 905  LEU A C   1 
ATOM   430  O O   . LEU A 1 55  ? -46.413  33.353 3.878   1.00 39.68  ? 905  LEU A O   1 
ATOM   431  C CB  . LEU A 1 55  ? -47.701  30.763 2.299   1.00 42.74  ? 905  LEU A CB  1 
ATOM   432  C CG  . LEU A 1 55  ? -47.623  29.279 1.965   1.00 42.04  ? 905  LEU A CG  1 
ATOM   433  C CD1 . LEU A 1 55  ? -48.961  28.603 2.213   1.00 38.86  ? 905  LEU A CD1 1 
ATOM   434  C CD2 . LEU A 1 55  ? -47.195  29.117 0.518   1.00 44.79  ? 905  LEU A CD2 1 
ATOM   435  N N   . GLY A 1 56  ? -47.151  33.756 1.792   1.00 38.92  ? 906  GLY A N   1 
ATOM   436  C CA  . GLY A 1 56  ? -47.727  35.022 2.183   1.00 41.49  ? 906  GLY A CA  1 
ATOM   437  C C   . GLY A 1 56  ? -49.160  34.804 2.635   1.00 38.18  ? 906  GLY A C   1 
ATOM   438  O O   . GLY A 1 56  ? -49.893  33.987 2.078   1.00 36.41  ? 906  GLY A O   1 
ATOM   439  N N   . VAL A 1 57  ? -49.566  35.585 3.640   1.00 40.69  ? 907  VAL A N   1 
ATOM   440  C CA  . VAL A 1 57  ? -50.904  35.425 4.204   1.00 41.06  ? 907  VAL A CA  1 
ATOM   441  C C   . VAL A 1 57  ? -51.957  35.625 3.131   1.00 39.03  ? 907  VAL A C   1 
ATOM   442  O O   . VAL A 1 57  ? -52.959  34.903 3.079   1.00 42.30  ? 907  VAL A O   1 
ATOM   443  C CB  . VAL A 1 57  ? -51.114  36.402 5.375   1.00 49.59  ? 907  VAL A CB  1 
ATOM   444  C CG1 . VAL A 1 57  ? -50.884  35.713 6.693   1.00 35.84  ? 907  VAL A CG1 1 
ATOM   445  C CG2 . VAL A 1 57  ? -50.159  37.575 5.246   1.00 46.17  ? 907  VAL A CG2 1 
ATOM   446  N N   . GLU A 1 58  ? -51.719  36.567 2.223   1.00 46.37  ? 908  GLU A N   1 
ATOM   447  C CA  . GLU A 1 58  ? -52.689  36.839 1.176   1.00 42.08  ? 908  GLU A CA  1 
ATOM   448  C C   . GLU A 1 58  ? -52.842  35.668 0.218   1.00 45.50  ? 908  GLU A C   1 
ATOM   449  O O   . GLU A 1 58  ? -53.749  35.687 -0.619  1.00 53.44  ? 908  GLU A O   1 
ATOM   450  C CB  . GLU A 1 58  ? -52.304  38.111 0.422   1.00 51.97  ? 908  GLU A CB  1 
ATOM   451  C CG  . GLU A 1 58  ? -52.559  39.382 1.232   1.00 60.21  ? 908  GLU A CG  1 
ATOM   452  C CD  . GLU A 1 58  ? -53.984  39.895 1.114   1.00 60.15  ? 908  GLU A CD  1 
ATOM   453  O OE1 . GLU A 1 58  ? -54.782  39.278 0.378   1.00 57.51  ? 908  GLU A OE1 1 
ATOM   454  O OE2 . GLU A 1 58  ? -54.305  40.916 1.759   1.00 54.85  ? 908  GLU A OE2 1 
ATOM   455  N N   . GLN A 1 59  ? -51.945  34.685 0.277   1.00 45.76  ? 909  GLN A N   1 
ATOM   456  C CA  . GLN A 1 59  ? -52.049  33.483 -0.537  1.00 45.80  ? 909  GLN A CA  1 
ATOM   457  C C   . GLN A 1 59  ? -52.418  32.249 0.281   1.00 47.48  ? 909  GLN A C   1 
ATOM   458  O O   . GLN A 1 59  ? -52.280  31.123 -0.206  1.00 48.46  ? 909  GLN A O   1 
ATOM   459  C CB  . GLN A 1 59  ? -50.738  33.269 -1.283  1.00 53.10  ? 909  GLN A CB  1 
ATOM   460  C CG  . GLN A 1 59  ? -50.777  33.923 -2.634  1.00 53.26  ? 909  GLN A CG  1 
ATOM   461  C CD  . GLN A 1 59  ? -50.569  35.421 -2.529  1.00 58.33  ? 909  GLN A CD  1 
ATOM   462  O OE1 . GLN A 1 59  ? -51.310  36.209 -3.117  1.00 59.92  ? 909  GLN A OE1 1 
ATOM   463  N NE2 . GLN A 1 59  ? -49.564  35.821 -1.763  1.00 58.11  ? 909  GLN A NE2 1 
ATOM   464  N N   . LEU A 1 60  ? -52.904  32.436 1.509   1.00 37.04  ? 910  LEU A N   1 
ATOM   465  C CA  . LEU A 1 60  ? -53.111  31.349 2.465   1.00 30.45  ? 910  LEU A CA  1 
ATOM   466  C C   . LEU A 1 60  ? -54.569  31.308 2.906   1.00 39.07  ? 910  LEU A C   1 
ATOM   467  O O   . LEU A 1 60  ? -54.962  32.024 3.841   1.00 30.77  ? 910  LEU A O   1 
ATOM   468  C CB  . LEU A 1 60  ? -52.190  31.508 3.674   1.00 29.76  ? 910  LEU A CB  1 
ATOM   469  C CG  . LEU A 1 60  ? -52.298  30.437 4.765   1.00 34.55  ? 910  LEU A CG  1 
ATOM   470  C CD1 . LEU A 1 60  ? -52.271  29.033 4.178   1.00 37.06  ? 910  LEU A CD1 1 
ATOM   471  C CD2 . LEU A 1 60  ? -51.222  30.612 5.819   1.00 29.84  ? 910  LEU A CD2 1 
ATOM   472  N N   . PRO A 1 61  ? -55.419  30.542 2.222   1.00 34.99  ? 911  PRO A N   1 
ATOM   473  C CA  . PRO A 1 61  ? -56.741  30.232 2.785   1.00 33.87  ? 911  PRO A CA  1 
ATOM   474  C C   . PRO A 1 61  ? -56.597  29.461 4.089   1.00 33.00  ? 911  PRO A C   1 
ATOM   475  O O   . PRO A 1 61  ? -55.761  28.563 4.208   1.00 30.23  ? 911  PRO A O   1 
ATOM   476  C CB  . PRO A 1 61  ? -57.406  29.377 1.701   1.00 34.64  ? 911  PRO A CB  1 
ATOM   477  C CG  . PRO A 1 61  ? -56.290  28.855 0.863   1.00 39.37  ? 911  PRO A CG  1 
ATOM   478  C CD  . PRO A 1 61  ? -55.146  29.814 0.971   1.00 38.28  ? 911  PRO A CD  1 
ATOM   479  N N   . VAL A 1 62  ? -57.414  29.818 5.081   1.00 30.35  ? 912  VAL A N   1 
ATOM   480  C CA  . VAL A 1 62  ? -57.157  29.365 6.443   1.00 27.14  ? 912  VAL A CA  1 
ATOM   481  C C   . VAL A 1 62  ? -58.467  29.080 7.174   1.00 31.75  ? 912  VAL A C   1 
ATOM   482  O O   . VAL A 1 62  ? -59.501  29.703 6.909   1.00 30.11  ? 912  VAL A O   1 
ATOM   483  C CB  . VAL A 1 62  ? -56.293  30.401 7.203   1.00 28.61  ? 912  VAL A CB  1 
ATOM   484  C CG1 . VAL A 1 62  ? -57.002  31.746 7.288   1.00 30.81  ? 912  VAL A CG1 1 
ATOM   485  C CG2 . VAL A 1 62  ? -55.893  29.886 8.575   1.00 27.96  ? 912  VAL A CG2 1 
ATOM   486  N N   . VAL A 1 63  ? -58.417  28.103 8.085   1.00 28.26  ? 913  VAL A N   1 
ATOM   487  C CA  . VAL A 1 63  ? -59.523  27.781 8.982   1.00 29.95  ? 913  VAL A CA  1 
ATOM   488  C C   . VAL A 1 63  ? -59.056  27.941 10.423  1.00 30.45  ? 913  VAL A C   1 
ATOM   489  O O   . VAL A 1 63  ? -57.983  27.451 10.793  1.00 29.79  ? 913  VAL A O   1 
ATOM   490  C CB  . VAL A 1 63  ? -60.055  26.351 8.766   1.00 30.75  ? 913  VAL A CB  1 
ATOM   491  C CG1 . VAL A 1 63  ? -61.365  26.155 9.529   1.00 31.98  ? 913  VAL A CG1 1 
ATOM   492  C CG2 . VAL A 1 63  ? -60.231  26.048 7.290   1.00 30.22  ? 913  VAL A CG2 1 
ATOM   493  N N   . PHE A 1 64  ? -59.866  28.628 11.225  1.00 27.47  ? 914  PHE A N   1 
ATOM   494  C CA  . PHE A 1 64  ? -59.767  28.643 12.678  1.00 27.57  ? 914  PHE A CA  1 
ATOM   495  C C   . PHE A 1 64  ? -60.910  27.826 13.255  1.00 32.97  ? 914  PHE A C   1 
ATOM   496  O O   . PHE A 1 64  ? -62.043  27.913 12.772  1.00 29.65  ? 914  PHE A O   1 
ATOM   497  C CB  . PHE A 1 64  ? -59.861  30.058 13.251  1.00 27.10  ? 914  PHE A CB  1 
ATOM   498  C CG  . PHE A 1 64  ? -58.778  30.975 12.796  1.00 30.49  ? 914  PHE A CG  1 
ATOM   499  C CD1 . PHE A 1 64  ? -58.884  31.645 11.592  1.00 29.19  ? 914  PHE A CD1 1 
ATOM   500  C CD2 . PHE A 1 64  ? -57.658  31.181 13.581  1.00 30.51  ? 914  PHE A CD2 1 
ATOM   501  C CE1 . PHE A 1 64  ? -57.889  32.499 11.173  1.00 32.94  ? 914  PHE A CE1 1 
ATOM   502  C CE2 . PHE A 1 64  ? -56.659  32.034 13.168  1.00 27.74  ? 914  PHE A CE2 1 
ATOM   503  C CZ  . PHE A 1 64  ? -56.773  32.694 11.962  1.00 27.42  ? 914  PHE A CZ  1 
ATOM   504  N N   . GLU A 1 65  ? -60.621  27.047 14.297  1.00 28.81  ? 915  GLU A N   1 
ATOM   505  C CA  . GLU A 1 65  ? -61.669  26.284 14.962  1.00 32.85  ? 915  GLU A CA  1 
ATOM   506  C C   . GLU A 1 65  ? -61.519  26.395 16.472  1.00 35.99  ? 915  GLU A C   1 
ATOM   507  O O   . GLU A 1 65  ? -60.402  26.495 16.998  1.00 30.33  ? 915  GLU A O   1 
ATOM   508  C CB  . GLU A 1 65  ? -61.655  24.806 14.547  1.00 35.69  ? 915  GLU A CB  1 
ATOM   509  C CG  . GLU A 1 65  ? -62.081  24.568 13.110  1.00 34.23  ? 915  GLU A CG  1 
ATOM   510  C CD  . GLU A 1 65  ? -61.907  23.126 12.679  1.00 44.92  ? 915  GLU A CD  1 
ATOM   511  O OE1 . GLU A 1 65  ? -61.383  22.318 13.474  1.00 45.18  ? 915  GLU A OE1 1 
ATOM   512  O OE2 . GLU A 1 65  ? -62.284  22.805 11.533  1.00 45.74  ? 915  GLU A OE2 1 
ATOM   513  N N   . ASP A 1 66  ? -62.670  26.391 17.156  1.00 32.07  ? 916  ASP A N   1 
ATOM   514  C CA  . ASP A 1 66  ? -62.750  26.353 18.618  1.00 34.05  ? 916  ASP A CA  1 
ATOM   515  C C   . ASP A 1 66  ? -61.916  27.458 19.260  1.00 32.80  ? 916  ASP A C   1 
ATOM   516  O O   . ASP A 1 66  ? -61.151  27.231 20.201  1.00 32.20  ? 916  ASP A O   1 
ATOM   517  C CB  . ASP A 1 66  ? -62.349  24.978 19.158  1.00 34.79  ? 916  ASP A CB  1 
ATOM   518  C CG  . ASP A 1 66  ? -63.157  23.850 18.545  1.00 44.82  ? 916  ASP A CG  1 
ATOM   519  O OD1 . ASP A 1 66  ? -64.380  24.024 18.363  1.00 43.48  ? 916  ASP A OD1 1 
ATOM   520  O OD2 . ASP A 1 66  ? -62.575  22.784 18.255  1.00 47.41  ? 916  ASP A OD2 1 
ATOM   521  N N   . VAL A 1 67  ? -62.055  28.671 18.727  1.00 30.76  ? 917  VAL A N   1 
ATOM   522  C CA  . VAL A 1 67  ? -61.330  29.811 19.270  1.00 28.38  ? 917  VAL A CA  1 
ATOM   523  C C   . VAL A 1 67  ? -61.935  30.206 20.609  1.00 36.68  ? 917  VAL A C   1 
ATOM   524  O O   . VAL A 1 67  ? -63.155  30.363 20.736  1.00 32.75  ? 917  VAL A O   1 
ATOM   525  C CB  . VAL A 1 67  ? -61.355  30.982 18.279  1.00 31.29  ? 917  VAL A CB  1 
ATOM   526  C CG1 . VAL A 1 67  ? -60.693  32.216 18.885  1.00 29.14  ? 917  VAL A CG1 1 
ATOM   527  C CG2 . VAL A 1 67  ? -60.678  30.579 16.980  1.00 29.82  ? 917  VAL A CG2 1 
ATOM   528  N N   . VAL A 1 68  ? -61.081  30.368 21.617  1.00 30.44  ? 918  VAL A N   1 
ATOM   529  C CA  . VAL A 1 68  ? -61.497  30.784 22.950  1.00 32.01  ? 918  VAL A CA  1 
ATOM   530  C C   . VAL A 1 68  ? -60.645  31.977 23.352  1.00 31.15  ? 918  VAL A C   1 
ATOM   531  O O   . VAL A 1 68  ? -59.411  31.891 23.351  1.00 29.78  ? 918  VAL A O   1 
ATOM   532  C CB  . VAL A 1 68  ? -61.361  29.652 23.982  1.00 31.13  ? 918  VAL A CB  1 
ATOM   533  C CG1 . VAL A 1 68  ? -61.783  30.136 25.364  1.00 33.50  ? 918  VAL A CG1 1 
ATOM   534  C CG2 . VAL A 1 68  ? -62.175  28.438 23.557  1.00 36.04  ? 918  VAL A CG2 1 
ATOM   535  N N   . LEU A 1 69  ? -61.297  33.080 23.706  1.00 27.74  ? 919  LEU A N   1 
ATOM   536  C CA  . LEU A 1 69  ? -60.618  34.282 24.167  1.00 30.13  ? 919  LEU A CA  1 
ATOM   537  C C   . LEU A 1 69  ? -60.695  34.303 25.686  1.00 38.93  ? 919  LEU A C   1 
ATOM   538  O O   . LEU A 1 69  ? -61.790  34.370 26.256  1.00 33.35  ? 919  LEU A O   1 
ATOM   539  C CB  . LEU A 1 69  ? -61.242  35.540 23.566  1.00 31.74  ? 919  LEU A CB  1 
ATOM   540  C CG  . LEU A 1 69  ? -61.151  35.602 22.040  1.00 39.75  ? 919  LEU A CG  1 
ATOM   541  C CD1 . LEU A 1 69  ? -62.486  35.248 21.399  1.00 38.92  ? 919  LEU A CD1 1 
ATOM   542  C CD2 . LEU A 1 69  ? -60.659  36.963 21.582  1.00 44.20  ? 919  LEU A CD2 1 
ATOM   543  N N   . HIS A 1 70  ? -59.538  34.196 26.334  1.00 31.42  ? 920  HIS A N   1 
ATOM   544  C CA  . HIS A 1 70  ? -59.478  34.003 27.775  1.00 33.62  ? 920  HIS A CA  1 
ATOM   545  C C   . HIS A 1 70  ? -59.410  35.303 28.560  1.00 34.52  ? 920  HIS A C   1 
ATOM   546  O O   . HIS A 1 70  ? -59.761  35.313 29.745  1.00 36.97  ? 920  HIS A O   1 
ATOM   547  C CB  . HIS A 1 70  ? -58.273  33.131 28.129  1.00 31.61  ? 920  HIS A CB  1 
ATOM   548  C CG  . HIS A 1 70  ? -58.298  31.787 27.473  1.00 29.52  ? 920  HIS A CG  1 
ATOM   549  N ND1 . HIS A 1 70  ? -58.924  30.698 28.037  1.00 33.24  ? 920  HIS A ND1 1 
ATOM   550  C CD2 . HIS A 1 70  ? -57.771  31.355 26.302  1.00 30.44  ? 920  HIS A CD2 1 
ATOM   551  C CE1 . HIS A 1 70  ? -58.786  29.653 27.241  1.00 37.51  ? 920  HIS A CE1 1 
ATOM   552  N NE2 . HIS A 1 70  ? -58.088  30.024 26.183  1.00 33.85  ? 920  HIS A NE2 1 
ATOM   553  N N   . GLN A 1 71  ? -58.946  36.382 27.941  1.00 29.05  ? 921  GLN A N   1 
ATOM   554  C CA  . GLN A 1 71  ? -58.864  37.678 28.596  1.00 35.57  ? 921  GLN A CA  1 
ATOM   555  C C   . GLN A 1 71  ? -58.698  38.741 27.522  1.00 36.40  ? 921  GLN A C   1 
ATOM   556  O O   . GLN A 1 71  ? -58.405  38.437 26.362  1.00 38.32  ? 921  GLN A O   1 
ATOM   557  C CB  . GLN A 1 71  ? -57.724  37.723 29.623  1.00 41.76  ? 921  GLN A CB  1 
ATOM   558  C CG  . GLN A 1 71  ? -56.327  37.587 29.042  1.00 38.88  ? 921  GLN A CG  1 
ATOM   559  C CD  . GLN A 1 71  ? -55.241  37.727 30.097  1.00 42.26  ? 921  GLN A CD  1 
ATOM   560  O OE1 . GLN A 1 71  ? -55.236  37.009 31.098  1.00 46.15  ? 921  GLN A OE1 1 
ATOM   561  N NE2 . GLN A 1 71  ? -54.312  38.648 29.872  1.00 41.36  ? 921  GLN A NE2 1 
ATOM   562  N N   . ALA A 1 72  ? -58.951  39.985 27.910  1.00 34.28  ? 922  ALA A N   1 
ATOM   563  C CA  . ALA A 1 72  ? -58.753  41.131 27.038  1.00 35.60  ? 922  ALA A CA  1 
ATOM   564  C C   . ALA A 1 72  ? -57.333  41.668 27.168  1.00 39.86  ? 922  ALA A C   1 
ATOM   565  O O   . ALA A 1 72  ? -56.658  41.458 28.180  1.00 41.26  ? 922  ALA A O   1 
ATOM   566  C CB  . ALA A 1 72  ? -59.757  42.239 27.360  1.00 37.17  ? 922  ALA A CB  1 
ATOM   567  N N   . THR A 1 73  ? -56.862  42.315 26.105  1.00 30.97  ? 923  THR A N   1 
ATOM   568  C CA  . THR A 1 73  ? -55.546  42.945 26.072  1.00 34.08  ? 923  THR A CA  1 
ATOM   569  C C   . THR A 1 73  ? -55.723  44.451 25.914  1.00 39.39  ? 923  THR A C   1 
ATOM   570  O O   . THR A 1 73  ? -56.218  44.912 24.880  1.00 32.50  ? 923  THR A O   1 
ATOM   571  C CB  . THR A 1 73  ? -54.680  42.380 24.946  1.00 34.35  ? 923  THR A CB  1 
ATOM   572  O OG1 . THR A 1 73  ? -54.479  40.976 25.157  1.00 36.55  ? 923  THR A OG1 1 
ATOM   573  C CG2 . THR A 1 73  ? -53.328  43.069 24.935  1.00 38.98  ? 923  THR A CG2 1 
ATOM   574  N N   . ILE A 1 74  ? -55.293  45.215 26.924  1.00 35.10  ? 924  ILE A N   1 
ATOM   575  C CA  . ILE A 1 74  ? -55.370  46.676 26.903  1.00 38.47  ? 924  ILE A CA  1 
ATOM   576  C C   . ILE A 1 74  ? -54.133  47.223 26.208  1.00 40.11  ? 924  ILE A C   1 
ATOM   577  O O   . ILE A 1 74  ? -53.008  46.842 26.548  1.00 42.23  ? 924  ILE A O   1 
ATOM   578  C CB  . ILE A 1 74  ? -55.424  47.254 28.329  1.00 46.84  ? 924  ILE A CB  1 
ATOM   579  C CG1 . ILE A 1 74  ? -56.491  46.616 29.213  1.00 48.60  ? 924  ILE A CG1 1 
ATOM   580  C CG2 . ILE A 1 74  ? -55.639  48.761 28.261  1.00 45.60  ? 924  ILE A CG2 1 
ATOM   581  C CD1 . ILE A 1 74  ? -57.824  46.621 28.640  1.00 51.54  ? 924  ILE A CD1 1 
ATOM   582  N N   . LEU A 1 75  ? -54.326  48.087 25.213  1.00 36.76  ? 925  LEU A N   1 
ATOM   583  C CA  . LEU A 1 75  ? -53.185  48.765 24.611  1.00 36.52  ? 925  LEU A CA  1 
ATOM   584  C C   . LEU A 1 75  ? -52.980  50.111 25.303  1.00 50.25  ? 925  LEU A C   1 
ATOM   585  O O   . LEU A 1 75  ? -53.819  51.007 25.140  1.00 44.83  ? 925  LEU A O   1 
ATOM   586  C CB  . LEU A 1 75  ? -53.395  48.946 23.115  1.00 43.05  ? 925  LEU A CB  1 
ATOM   587  C CG  . LEU A 1 75  ? -53.900  47.678 22.405  1.00 38.34  ? 925  LEU A CG  1 
ATOM   588  C CD1 . LEU A 1 75  ? -54.404  47.954 20.990  1.00 38.29  ? 925  LEU A CD1 1 
ATOM   589  C CD2 . LEU A 1 75  ? -52.847  46.592 22.400  1.00 40.96  ? 925  LEU A CD2 1 
ATOM   590  N N   . PRO A 1 76  ? -51.856  50.339 25.981  1.00 49.23  ? 926  PRO A N   1 
ATOM   591  C CA  . PRO A 1 76  ? -51.669  51.622 26.675  1.00 50.71  ? 926  PRO A CA  1 
ATOM   592  C C   . PRO A 1 76  ? -51.385  52.736 25.674  1.00 54.86  ? 926  PRO A C   1 
ATOM   593  O O   . PRO A 1 76  ? -51.041  52.486 24.518  1.00 57.02  ? 926  PRO A O   1 
ATOM   594  C CB  . PRO A 1 76  ? -50.478  51.358 27.608  1.00 54.14  ? 926  PRO A CB  1 
ATOM   595  C CG  . PRO A 1 76  ? -49.784  50.139 27.060  1.00 58.15  ? 926  PRO A CG  1 
ATOM   596  C CD  . PRO A 1 76  ? -50.732  49.403 26.164  1.00 51.92  ? 926  PRO A CD  1 
ATOM   597  N N   . LYS A 1 77  ? -51.433  53.987 26.154  1.00 60.49  ? 927  LYS A N   1 
ATOM   598  C CA  . LYS A 1 77  ? -51.295  55.119 25.238  1.00 61.38  ? 927  LYS A CA  1 
ATOM   599  C C   . LYS A 1 77  ? -49.870  55.247 24.791  1.00 61.13  ? 927  LYS A C   1 
ATOM   600  O O   . LYS A 1 77  ? -49.591  55.603 23.632  1.00 60.60  ? 927  LYS A O   1 
ATOM   601  C CB  . LYS A 1 77  ? -51.706  56.412 25.949  1.00 67.34  ? 927  LYS A CB  1 
ATOM   602  C CG  . LYS A 1 77  ? -51.665  57.676 25.101  1.00 69.39  ? 927  LYS A CG  1 
ATOM   603  C CD  . LYS A 1 77  ? -52.945  57.904 24.329  1.00 72.21  ? 927  LYS A CD  1 
ATOM   604  C CE  . LYS A 1 77  ? -53.269  59.390 24.215  1.00 75.34  ? 927  LYS A CE  1 
ATOM   605  N NZ  . LYS A 1 77  ? -52.522  60.033 23.094  1.00 77.85  ? 927  LYS A NZ  1 
ATOM   606  N N   . THR A 1 78  ? -49.041  54.892 25.773  1.00 61.58  ? 928  THR A N   1 
ATOM   607  C CA  . THR A 1 78  ? -47.588  54.870 25.571  1.00 65.36  ? 928  THR A CA  1 
ATOM   608  C C   . THR A 1 78  ? -47.086  53.475 25.945  1.00 57.85  ? 928  THR A C   1 
ATOM   609  O O   . THR A 1 78  ? -47.616  52.900 26.891  1.00 58.56  ? 928  THR A O   1 
ATOM   610  C CB  . THR A 1 78  ? -46.900  55.996 26.358  1.00 69.49  ? 928  THR A CB  1 
ATOM   611  O OG1 . THR A 1 78  ? -47.059  57.212 25.627  1.00 73.80  ? 928  THR A OG1 1 
ATOM   612  C CG2 . THR A 1 78  ? -45.429  55.740 26.599  1.00 68.61  ? 928  THR A CG2 1 
ATOM   613  N N   . GLY A 1 79  ? -46.062  53.003 25.282  1.00 56.90  ? 929  GLY A N   1 
ATOM   614  C CA  . GLY A 1 79  ? -45.428  51.704 25.348  1.00 61.51  ? 929  GLY A CA  1 
ATOM   615  C C   . GLY A 1 79  ? -45.874  50.764 24.229  1.00 56.28  ? 929  GLY A C   1 
ATOM   616  O O   . GLY A 1 79  ? -46.576  51.135 23.277  1.00 54.24  ? 929  GLY A O   1 
ATOM   617  N N   . THR A 1 80  ? -45.418  49.520 24.345  1.00 41.60  ? 930  THR A N   1 
ATOM   618  C CA  . THR A 1 80  ? -45.666  48.488 23.352  1.00 49.12  ? 930  THR A CA  1 
ATOM   619  C C   . THR A 1 80  ? -46.258  47.266 24.043  1.00 51.27  ? 930  THR A C   1 
ATOM   620  O O   . THR A 1 80  ? -45.896  46.950 25.178  1.00 50.44  ? 930  THR A O   1 
ATOM   621  C CB  . THR A 1 80  ? -44.340  48.123 22.641  1.00 54.18  ? 930  THR A CB  1 
ATOM   622  O OG1 . THR A 1 80  ? -44.017  49.136 21.683  1.00 61.36  ? 930  THR A OG1 1 
ATOM   623  C CG2 . THR A 1 80  ? -44.422  46.778 21.931  1.00 50.99  ? 930  THR A CG2 1 
ATOM   624  N N   . VAL A 1 81  ? -47.135  46.546 23.348  1.00 45.53  ? 931  VAL A N   1 
ATOM   625  C CA  A VAL A 1 81  ? -47.627  45.265 23.849  0.52 41.96  ? 931  VAL A CA  1 
ATOM   626  C CA  B VAL A 1 81  ? -47.527  45.265 23.849  0.48 41.95  ? 931  VAL A CA  1 
ATOM   627  C C   . VAL A 1 81  ? -46.974  44.181 23.008  1.00 32.93  ? 931  VAL A C   1 
ATOM   628  O O   . VAL A 1 81  ? -46.853  44.323 21.795  1.00 36.17  ? 931  VAL A O   1 
ATOM   629  C CB  A VAL A 1 81  ? -49.167  45.134 23.821  0.52 41.94  ? 931  VAL A CB  1 
ATOM   630  C CB  B VAL A 1 81  ? -49.067  45.134 23.821  0.48 41.94  ? 931  VAL A CB  1 
ATOM   631  C CG1 A VAL A 1 81  ? -49.821  46.161 24.731  0.52 45.48  ? 931  VAL A CG1 1 
ATOM   632  C CG1 B VAL A 1 81  ? -49.506  43.738 24.233  0.48 38.44  ? 931  VAL A CG1 1 
ATOM   633  C CG2 A VAL A 1 81  ? -49.707  45.229 22.433  0.52 40.06  ? 931  VAL A CG2 1 
ATOM   634  C CG2 B VAL A 1 81  ? -49.728  46.173 24.665  0.48 45.49  ? 931  VAL A CG2 1 
ATOM   635  N N   . SER A 1 82  ? -46.521  43.114 23.639  1.00 33.21  ? 932  SER A N   1 
ATOM   636  C CA  A SER A 1 82  ? -45.914  42.017 22.896  0.58 32.17  ? 932  SER A CA  1 
ATOM   637  C CA  B SER A 1 82  ? -45.814  42.017 22.896  0.42 32.21  ? 932  SER A CA  1 
ATOM   638  C C   . SER A 1 82  ? -46.792  40.786 23.021  1.00 29.33  ? 932  SER A C   1 
ATOM   639  O O   . SER A 1 82  ? -46.994  40.270 24.124  1.00 31.45  ? 932  SER A O   1 
ATOM   640  C CB  A SER A 1 82  ? -44.494  41.731 23.378  0.58 35.99  ? 932  SER A CB  1 
ATOM   641  C CB  B SER A 1 82  ? -44.394  41.731 23.378  0.42 35.96  ? 932  SER A CB  1 
ATOM   642  O OG  A SER A 1 82  ? -43.718  42.916 23.355  0.58 36.73  ? 932  SER A OG  1 
ATOM   643  O OG  B SER A 1 82  ? -43.833  40.655 22.647  0.42 33.86  ? 932  SER A OG  1 
ATOM   644  N N   . LEU A 1 83  ? -47.313  40.325 21.891  1.00 28.32  ? 933  LEU A N   1 
ATOM   645  C CA  . LEU A 1 83  ? -48.169  39.154 21.842  1.00 25.15  ? 933  LEU A CA  1 
ATOM   646  C C   . LEU A 1 83  ? -47.387  38.012 21.214  1.00 24.62  ? 933  LEU A C   1 
ATOM   647  O O   . LEU A 1 83  ? -46.857  38.156 20.109  1.00 26.71  ? 933  LEU A O   1 
ATOM   648  C CB  . LEU A 1 83  ? -49.433  39.452 21.036  1.00 28.42  ? 933  LEU A CB  1 
ATOM   649  C CG  . LEU A 1 83  ? -50.308  40.525 21.685  1.00 29.66  ? 933  LEU A CG  1 
ATOM   650  C CD1 . LEU A 1 83  ? -51.440  40.926 20.756  1.00 31.51  ? 933  LEU A CD1 1 
ATOM   651  C CD2 . LEU A 1 83  ? -50.842  40.049 23.029  1.00 28.74  ? 933  LEU A CD2 1 
ATOM   652  N N   . GLU A 1 84  ? -47.314  36.884 21.910  1.00 25.12  ? 934  GLU A N   1 
ATOM   653  C CA  . GLU A 1 84  ? -46.606  35.715 21.412  1.00 24.80  ? 934  GLU A CA  1 
ATOM   654  C C   . GLU A 1 84  ? -47.612  34.700 20.895  1.00 25.19  ? 934  GLU A C   1 
ATOM   655  O O   . GLU A 1 84  ? -48.596  34.399 21.572  1.00 24.92  ? 934  GLU A O   1 
ATOM   656  C CB  . GLU A 1 84  ? -45.760  35.059 22.501  1.00 26.51  ? 934  GLU A CB  1 
ATOM   657  C CG  . GLU A 1 84  ? -45.007  33.858 21.971  1.00 25.78  ? 934  GLU A CG  1 
ATOM   658  C CD  . GLU A 1 84  ? -44.017  33.287 22.950  1.00 31.05  ? 934  GLU A CD  1 
ATOM   659  O OE1 . GLU A 1 84  ? -43.222  34.046 23.544  1.00 40.07  ? 934  GLU A OE1 1 
ATOM   660  O OE2 . GLU A 1 84  ? -44.054  32.053 23.117  1.00 33.34  ? 934  GLU A OE2 1 
ATOM   661  N N   . VAL A 1 85  ? -47.355  34.163 19.709  1.00 24.41  ? 935  VAL A N   1 
ATOM   662  C CA  . VAL A 1 85  ? -48.141  33.083 19.133  1.00 22.81  ? 935  VAL A CA  1 
ATOM   663  C C   . VAL A 1 85  ? -47.274  31.832 19.123  1.00 24.44  ? 935  VAL A C   1 
ATOM   664  O O   . VAL A 1 85  ? -46.133  31.866 18.647  1.00 25.48  ? 935  VAL A O   1 
ATOM   665  C CB  . VAL A 1 85  ? -48.613  33.430 17.711  1.00 23.30  ? 935  VAL A CB  1 
ATOM   666  C CG1 . VAL A 1 85  ? -49.373  32.257 17.104  1.00 23.36  ? 935  VAL A CG1 1 
ATOM   667  C CG2 . VAL A 1 85  ? -49.435  34.718 17.708  1.00 24.97  ? 935  VAL A CG2 1 
ATOM   668  N N   . ARG A 1 86  ? -47.814  30.731 19.637  1.00 23.01  ? 936  ARG A N   1 
ATOM   669  C CA  . ARG A 1 86  ? -47.154  29.433 19.601  1.00 22.83  ? 936  ARG A CA  1 
ATOM   670  C C   . ARG A 1 86  ? -48.023  28.446 18.838  1.00 25.55  ? 936  ARG A C   1 
ATOM   671  O O   . ARG A 1 86  ? -49.233  28.370 19.075  1.00 28.21  ? 936  ARG A O   1 
ATOM   672  C CB  . ARG A 1 86  ? -46.888  28.893 21.012  1.00 25.88  ? 936  ARG A CB  1 
ATOM   673  C CG  . ARG A 1 86  ? -45.834  29.655 21.801  1.00 27.52  ? 936  ARG A CG  1 
ATOM   674  C CD  . ARG A 1 86  ? -45.667  29.107 23.221  1.00 29.89  ? 936  ARG A CD  1 
ATOM   675  N NE  . ARG A 1 86  ? -46.879  29.194 24.028  1.00 29.51  ? 936  ARG A NE  1 
ATOM   676  C CZ  . ARG A 1 86  ? -47.232  30.249 24.751  1.00 29.69  ? 936  ARG A CZ  1 
ATOM   677  N NH1 . ARG A 1 86  ? -46.485  31.340 24.795  1.00 27.89  ? 936  ARG A NH1 1 
ATOM   678  N NH2 . ARG A 1 86  ? -48.360  30.204 25.455  1.00 28.62  ? 936  ARG A NH2 1 
ATOM   679  N N   . LEU A 1 87  ? -47.404  27.681 17.941  1.00 24.57  ? 937  LEU A N   1 
ATOM   680  C CA  . LEU A 1 87  ? -48.064  26.566 17.273  1.00 28.33  ? 937  LEU A CA  1 
ATOM   681  C C   . LEU A 1 87  ? -47.609  25.286 17.961  1.00 27.22  ? 937  LEU A C   1 
ATOM   682  O O   . LEU A 1 87  ? -46.405  25.020 18.036  1.00 26.88  ? 937  LEU A O   1 
ATOM   683  C CB  . LEU A 1 87  ? -47.721  26.533 15.784  1.00 30.01  ? 937  LEU A CB  1 
ATOM   684  C CG  . LEU A 1 87  ? -48.009  27.801 14.978  1.00 29.23  ? 937  LEU A CG  1 
ATOM   685  C CD1 . LEU A 1 87  ? -47.755  27.570 13.496  1.00 28.34  ? 937  LEU A CD1 1 
ATOM   686  C CD2 . LEU A 1 87  ? -49.437  28.262 15.211  1.00 28.34  ? 937  LEU A CD2 1 
ATOM   687  N N   . LEU A 1 88  ? -48.558  24.505 18.473  1.00 26.68  ? 938  LEU A N   1 
ATOM   688  C CA  . LEU A 1 88  ? -48.193  23.333 19.259  1.00 23.71  ? 938  LEU A CA  1 
ATOM   689  C C   . LEU A 1 88  ? -47.550  22.260 18.383  1.00 29.51  ? 938  LEU A C   1 
ATOM   690  O O   . LEU A 1 88  ? -47.851  22.131 17.194  1.00 32.38  ? 938  LEU A O   1 
ATOM   691  C CB  . LEU A 1 88  ? -49.416  22.763 19.982  1.00 28.16  ? 938  LEU A CB  1 
ATOM   692  C CG  . LEU A 1 88  ? -49.783  23.370 21.345  1.00 30.24  ? 938  LEU A CG  1 
ATOM   693  C CD1 . LEU A 1 88  ? -50.225  24.831 21.240  1.00 28.03  ? 938  LEU A CD1 1 
ATOM   694  C CD2 . LEU A 1 88  ? -50.842  22.530 22.057  1.00 33.30  ? 938  LEU A CD2 1 
ATOM   695  N N   . GLU A 1 89  ? -46.644  21.494 18.990  1.00 30.52  ? 939  GLU A N   1 
ATOM   696  C CA  . GLU A 1 89  ? -45.930  20.442 18.274  1.00 28.58  ? 939  GLU A CA  1 
ATOM   697  C C   . GLU A 1 89  ? -46.899  19.417 17.704  1.00 32.55  ? 939  GLU A C   1 
ATOM   698  O O   . GLU A 1 89  ? -47.786  18.929 18.410  1.00 32.12  ? 939  GLU A O   1 
ATOM   699  C CB  . GLU A 1 89  ? -44.959  19.741 19.218  1.00 30.34  ? 939  GLU A CB  1 
ATOM   700  C CG  . GLU A 1 89  ? -44.110  18.673 18.568  1.00 33.57  ? 939  GLU A CG  1 
ATOM   701  C CD  . GLU A 1 89  ? -43.288  17.924 19.588  1.00 37.06  ? 939  GLU A CD  1 
ATOM   702  O OE1 . GLU A 1 89  ? -43.879  17.165 20.386  1.00 41.70  ? 939  GLU A OE1 1 
ATOM   703  O OE2 . GLU A 1 89  ? -42.060  18.133 19.625  1.00 36.17  ? 939  GLU A OE2 1 
ATOM   704  N N   . ALA A 1 90  ? -46.706  19.073 16.428  1.00 31.92  ? 940  ALA A N   1 
ATOM   705  C CA  . ALA A 1 90  ? -47.455  17.995 15.782  1.00 39.04  ? 940  ALA A CA  1 
ATOM   706  C C   . ALA A 1 90  ? -48.959  18.180 15.960  1.00 37.25  ? 940  ALA A C   1 
ATOM   707  O O   . ALA A 1 90  ? -49.702  17.227 16.206  1.00 39.54  ? 940  ALA A O   1 
ATOM   708  C CB  . ALA A 1 90  ? -47.011  16.632 16.315  1.00 37.92  ? 940  ALA A CB  1 
ATOM   709  N N   . SER A 1 91  ? -49.416  19.420 15.822  1.00 33.50  ? 941  SER A N   1 
ATOM   710  C CA  . SER A 1 91  ? -50.794  19.738 16.157  1.00 34.35  ? 941  SER A CA  1 
ATOM   711  C C   . SER A 1 91  ? -51.209  20.989 15.401  1.00 33.67  ? 941  SER A C   1 
ATOM   712  O O   . SER A 1 91  ? -50.372  21.784 14.966  1.00 31.85  ? 941  SER A O   1 
ATOM   713  C CB  . SER A 1 91  ? -50.965  19.929 17.669  1.00 34.64  ? 941  SER A CB  1 
ATOM   714  O OG  . SER A 1 91  ? -52.232  20.476 17.985  1.00 33.84  ? 941  SER A OG  1 
ATOM   715  N N   . ARG A 1 92  ? -52.518  21.138 15.234  1.00 31.57  ? 942  ARG A N   1 
ATOM   716  C CA  . ARG A 1 92  ? -53.100  22.355 14.693  1.00 32.49  ? 942  ARG A CA  1 
ATOM   717  C C   . ARG A 1 92  ? -53.412  23.385 15.769  1.00 29.10  ? 942  ARG A C   1 
ATOM   718  O O   . ARG A 1 92  ? -53.803  24.510 15.437  1.00 30.07  ? 942  ARG A O   1 
ATOM   719  C CB  . ARG A 1 92  ? -54.358  22.003 13.897  1.00 32.40  ? 942  ARG A CB  1 
ATOM   720  C CG  . ARG A 1 92  ? -54.051  21.253 12.606  1.00 36.40  ? 942  ARG A CG  1 
ATOM   721  C CD  . ARG A 1 92  ? -55.312  20.673 11.997  1.00 41.99  ? 942  ARG A CD  1 
ATOM   722  N NE  . ARG A 1 92  ? -55.087  20.111 10.671  1.00 46.08  ? 942  ARG A NE  1 
ATOM   723  C CZ  . ARG A 1 92  ? -56.058  19.719 9.858   1.00 52.40  ? 942  ARG A CZ  1 
ATOM   724  N NH1 . ARG A 1 92  ? -57.327  19.753 10.232  1.00 49.08  ? 942  ARG A NH1 1 
ATOM   725  N NH2 . ARG A 1 92  ? -55.752  19.302 8.633   1.00 50.80  ? 942  ARG A NH2 1 
ATOM   726  N N   . ALA A 1 93  ? -53.246  23.026 17.038  1.00 28.69  ? 943  ALA A N   1 
ATOM   727  C CA  . ALA A 1 93  ? -53.560  23.929 18.132  1.00 30.18  ? 943  ALA A CA  1 
ATOM   728  C C   . ALA A 1 93  ? -52.568  25.087 18.178  1.00 29.81  ? 943  ALA A C   1 
ATOM   729  O O   . ALA A 1 93  ? -51.394  24.952 17.812  1.00 30.96  ? 943  ALA A O   1 
ATOM   730  C CB  . ALA A 1 93  ? -53.553  23.178 19.464  1.00 31.46  ? 943  ALA A CB  1 
ATOM   731  N N   . PHE A 1 94  ? -53.058  26.238 18.633  1.00 28.59  ? 944  PHE A N   1 
ATOM   732  C CA  . PHE A 1 94  ? -52.237  27.426 18.807  1.00 28.66  ? 944  PHE A CA  1 
ATOM   733  C C   . PHE A 1 94  ? -52.562  28.064 20.149  1.00 27.42  ? 944  PHE A C   1 
ATOM   734  O O   . PHE A 1 94  ? -53.619  27.825 20.738  1.00 26.58  ? 944  PHE A O   1 
ATOM   735  C CB  . PHE A 1 94  ? -52.448  28.442 17.667  1.00 27.41  ? 944  PHE A CB  1 
ATOM   736  C CG  . PHE A 1 94  ? -53.784  29.154 17.709  1.00 29.84  ? 944  PHE A CG  1 
ATOM   737  C CD1 . PHE A 1 94  ? -53.968  30.283 18.497  1.00 24.96  ? 944  PHE A CD1 1 
ATOM   738  C CD2 . PHE A 1 94  ? -54.850  28.698 16.950  1.00 29.14  ? 944  PHE A CD2 1 
ATOM   739  C CE1 . PHE A 1 94  ? -55.191  30.933 18.538  1.00 27.88  ? 944  PHE A CE1 1 
ATOM   740  C CE2 . PHE A 1 94  ? -56.075  29.349 16.981  1.00 29.63  ? 944  PHE A CE2 1 
ATOM   741  C CZ  . PHE A 1 94  ? -56.246  30.466 17.779  1.00 26.02  ? 944  PHE A CZ  1 
ATOM   742  N N   . GLU A 1 95  ? -51.636  28.893 20.617  1.00 25.20  ? 945  GLU A N   1 
ATOM   743  C CA  . GLU A 1 95  ? -51.826  29.713 21.805  1.00 24.65  ? 945  GLU A CA  1 
ATOM   744  C C   . GLU A 1 95  ? -51.341  31.122 21.500  1.00 25.68  ? 945  GLU A C   1 
ATOM   745  O O   . GLU A 1 95  ? -50.385  31.303 20.745  1.00 25.92  ? 945  GLU A O   1 
ATOM   746  C CB  . GLU A 1 95  ? -51.068  29.144 23.027  1.00 23.60  ? 945  GLU A CB  1 
ATOM   747  C CG  . GLU A 1 95  ? -51.486  27.729 23.425  1.00 28.99  ? 945  GLU A CG  1 
ATOM   748  C CD  . GLU A 1 95  ? -50.496  27.030 24.352  1.00 34.84  ? 945  GLU A CD  1 
ATOM   749  O OE1 . GLU A 1 95  ? -49.468  27.636 24.726  1.00 32.77  ? 945  GLU A OE1 1 
ATOM   750  O OE2 . GLU A 1 95  ? -50.748  25.858 24.700  1.00 35.92  ? 945  GLU A OE2 1 
ATOM   751  N N   . VAL A 1 96  ? -52.023  32.117 22.057  1.00 24.87  ? 946  VAL A N   1 
ATOM   752  C CA  . VAL A 1 96  ? -51.552  33.497 22.065  1.00 23.98  ? 946  VAL A CA  1 
ATOM   753  C C   . VAL A 1 96  ? -51.414  33.897 23.522  1.00 27.54  ? 946  VAL A C   1 
ATOM   754  O O   . VAL A 1 96  ? -52.330  33.667 24.311  1.00 26.42  ? 946  VAL A O   1 
ATOM   755  C CB  . VAL A 1 96  ? -52.513  34.447 21.326  1.00 23.63  ? 946  VAL A CB  1 
ATOM   756  C CG1 . VAL A 1 96  ? -51.965  35.872 21.332  1.00 24.77  ? 946  VAL A CG1 1 
ATOM   757  C CG2 . VAL A 1 96  ? -52.753  33.967 19.904  1.00 25.40  ? 946  VAL A CG2 1 
ATOM   758  N N   . SER A 1 97  ? -50.270  34.459 23.888  1.00 24.42  ? 947  SER A N   1 
ATOM   759  C CA  . SER A 1 97  ? -50.032  34.844 25.270  1.00 25.91  ? 947  SER A CA  1 
ATOM   760  C C   . SER A 1 97  ? -49.447  36.246 25.330  1.00 28.66  ? 947  SER A C   1 
ATOM   761  O O   . SER A 1 97  ? -48.861  36.747 24.367  1.00 27.09  ? 947  SER A O   1 
ATOM   762  C CB  . SER A 1 97  ? -49.100  33.849 25.985  1.00 29.77  ? 947  SER A CB  1 
ATOM   763  O OG  . SER A 1 97  ? -47.829  33.786 25.364  1.00 29.03  ? 947  SER A OG  1 
ATOM   764  N N   . GLU A 1 98  ? -49.627  36.882 26.483  1.00 26.84  ? 948  GLU A N   1 
ATOM   765  C CA  . GLU A 1 98  ? -48.986  38.160 26.768  1.00 26.70  ? 948  GLU A CA  1 
ATOM   766  C C   . GLU A 1 98  ? -48.385  38.072 28.160  1.00 29.07  ? 948  GLU A C   1 
ATOM   767  O O   . GLU A 1 98  ? -49.090  37.745 29.121  1.00 32.62  ? 948  GLU A O   1 
ATOM   768  C CB  . GLU A 1 98  ? -49.965  39.333 26.669  1.00 33.72  ? 948  GLU A CB  1 
ATOM   769  C CG  . GLU A 1 98  ? -49.308  40.672 26.980  1.00 38.39  ? 948  GLU A CG  1 
ATOM   770  C CD  . GLU A 1 98  ? -50.250  41.668 27.617  1.00 50.00  ? 948  GLU A CD  1 
ATOM   771  O OE1 . GLU A 1 98  ? -51.174  41.240 28.338  1.00 50.00  ? 948  GLU A OE1 1 
ATOM   772  O OE2 . GLU A 1 98  ? -50.064  42.883 27.393  1.00 55.42  ? 948  GLU A OE2 1 
ATOM   773  N N   . ASN A 1 99  ? -47.076  38.315 28.254  1.00 32.95  ? 949  ASN A N   1 
ATOM   774  C CA  . ASN A 1 99  ? -46.339  38.181 29.511  1.00 38.15  ? 949  ASN A CA  1 
ATOM   775  C C   . ASN A 1 99  ? -46.585  36.814 30.144  1.00 39.18  ? 949  ASN A C   1 
ATOM   776  O O   . ASN A 1 99  ? -46.736  36.684 31.360  1.00 44.89  ? 949  ASN A O   1 
ATOM   777  C CB  . ASN A 1 99  ? -46.672  39.311 30.486  1.00 46.18  ? 949  ASN A CB  1 
ATOM   778  C CG  . ASN A 1 99  ? -46.227  40.666 29.977  1.00 50.84  ? 949  ASN A CG  1 
ATOM   779  O OD1 . ASN A 1 99  ? -45.154  40.798 29.386  1.00 56.06  ? 949  ASN A OD1 1 
ATOM   780  N ND2 . ASN A 1 99  ? -47.044  41.684 30.214  1.00 49.58  ? 949  ASN A ND2 1 
ATOM   781  N N   . GLY A 1 100 ? -46.674  35.787 29.298  1.00 35.50  ? 950  GLY A N   1 
ATOM   782  C CA  . GLY A 1 100 ? -46.896  34.429 29.745  1.00 38.37  ? 950  GLY A CA  1 
ATOM   783  C C   . GLY A 1 100 ? -48.333  34.047 30.028  1.00 44.36  ? 950  GLY A C   1 
ATOM   784  O O   . GLY A 1 100 ? -48.627  32.849 30.125  1.00 49.09  ? 950  GLY A O   1 
ATOM   785  N N   . ASN A 1 101 ? -49.240  35.015 30.161  1.00 37.35  ? 951  ASN A N   1 
ATOM   786  C CA  . ASN A 1 101 ? -50.644  34.720 30.424  1.00 37.48  ? 951  ASN A CA  1 
ATOM   787  C C   . ASN A 1 101 ? -51.352  34.339 29.131  1.00 32.16  ? 951  ASN A C   1 
ATOM   788  O O   . ASN A 1 101 ? -51.193  35.010 28.107  1.00 28.29  ? 951  ASN A O   1 
ATOM   789  C CB  . ASN A 1 101 ? -51.341  35.933 31.036  1.00 37.48  ? 951  ASN A CB  1 
ATOM   790  C CG  . ASN A 1 101 ? -50.787  36.305 32.391  1.00 48.58  ? 951  ASN A CG  1 
ATOM   791  O OD1 . ASN A 1 101 ? -50.285  35.459 33.130  1.00 50.60  ? 951  ASN A OD1 1 
ATOM   792  N ND2 . ASN A 1 101 ? -50.856  37.589 32.716  1.00 51.90  ? 951  ASN A ND2 1 
ATOM   793  N N   . LEU A 1 102 ? -52.154  33.276 29.185  1.00 31.05  ? 952  LEU A N   1 
ATOM   794  C CA  . LEU A 1 102 ? -52.865  32.816 27.998  1.00 30.91  ? 952  LEU A CA  1 
ATOM   795  C C   . LEU A 1 102 ? -54.003  33.776 27.651  1.00 33.22  ? 952  LEU A C   1 
ATOM   796  O O   . LEU A 1 102 ? -54.841  34.096 28.499  1.00 31.59  ? 952  LEU A O   1 
ATOM   797  C CB  . LEU A 1 102 ? -53.406  31.403 28.223  1.00 31.71  ? 952  LEU A CB  1 
ATOM   798  C CG  . LEU A 1 102 ? -54.067  30.708 27.029  1.00 30.69  ? 952  LEU A CG  1 
ATOM   799  C CD1 . LEU A 1 102 ? -53.028  30.397 25.958  1.00 30.17  ? 952  LEU A CD1 1 
ATOM   800  C CD2 . LEU A 1 102 ? -54.793  29.444 27.463  1.00 30.54  ? 952  LEU A CD2 1 
ATOM   801  N N   . VAL A 1 103 ? -54.022  34.248 26.406  1.00 28.72  ? 953  VAL A N   1 
ATOM   802  C CA  . VAL A 1 103 ? -55.030  35.174 25.917  1.00 28.01  ? 953  VAL A CA  1 
ATOM   803  C C   . VAL A 1 103 ? -55.994  34.499 24.944  1.00 29.16  ? 953  VAL A C   1 
ATOM   804  O O   . VAL A 1 103 ? -57.197  34.767 24.981  1.00 30.64  ? 953  VAL A O   1 
ATOM   805  C CB  . VAL A 1 103 ? -54.368  36.412 25.268  1.00 28.72  ? 953  VAL A CB  1 
ATOM   806  C CG1 . VAL A 1 103 ? -55.426  37.392 24.774  1.00 28.64  ? 953  VAL A CG1 1 
ATOM   807  C CG2 . VAL A 1 103 ? -53.424  37.096 26.252  1.00 32.46  ? 953  VAL A CG2 1 
ATOM   808  N N   . VAL A 1 104 ? -55.488  33.654 24.040  1.00 25.86  ? 954  VAL A N   1 
ATOM   809  C CA  . VAL A 1 104 ? -56.314  32.964 23.049  1.00 27.67  ? 954  VAL A CA  1 
ATOM   810  C C   . VAL A 1 104 ? -55.828  31.526 22.905  1.00 31.32  ? 954  VAL A C   1 
ATOM   811  O O   . VAL A 1 104 ? -54.624  31.258 22.973  1.00 29.18  ? 954  VAL A O   1 
ATOM   812  C CB  . VAL A 1 104 ? -56.288  33.657 21.665  1.00 29.22  ? 954  VAL A CB  1 
ATOM   813  C CG1 . VAL A 1 104 ? -57.339  33.043 20.734  1.00 28.39  ? 954  VAL A CG1 1 
ATOM   814  C CG2 . VAL A 1 104 ? -56.474  35.163 21.778  1.00 29.82  ? 954  VAL A CG2 1 
ATOM   815  N N   . SER A 1 105 ? -56.768  30.603 22.691  1.00 28.32  ? 955  SER A N   1 
ATOM   816  C CA  . SER A 1 105 ? -56.474  29.238 22.274  1.00 26.26  ? 955  SER A CA  1 
ATOM   817  C C   . SER A 1 105 ? -57.415  28.868 21.132  1.00 29.45  ? 955  SER A C   1 
ATOM   818  O O   . SER A 1 105 ? -58.438  29.521 20.911  1.00 29.19  ? 955  SER A O   1 
ATOM   819  C CB  . SER A 1 105 ? -56.599  28.252 23.447  1.00 30.91  ? 955  SER A CB  1 
ATOM   820  O OG  . SER A 1 105 ? -57.858  28.381 24.083  1.00 31.55  ? 955  SER A OG  1 
ATOM   821  N N   . GLY A 1 106 ? -57.073  27.797 20.431  1.00 30.42  ? 956  GLY A N   1 
ATOM   822  C CA  . GLY A 1 106 ? -57.800  27.399 19.247  1.00 31.76  ? 956  GLY A CA  1 
ATOM   823  C C   . GLY A 1 106 ? -56.945  26.477 18.403  1.00 31.59  ? 956  GLY A C   1 
ATOM   824  O O   . GLY A 1 106 ? -55.910  25.977 18.837  1.00 30.68  ? 956  GLY A O   1 
ATOM   825  N N   . LYS A 1 107 ? -57.508  26.197 17.235  1.00 30.14  ? 957  LYS A N   1 
ATOM   826  C CA  . LYS A 1 107 ? -56.810  25.383 16.235  1.00 26.75  ? 957  LYS A CA  1 
ATOM   827  C C   . LYS A 1 107 ? -56.753  26.245 14.980  1.00 30.75  ? 957  LYS A C   1 
ATOM   828  O O   . LYS A 1 107 ? -57.661  27.043 14.761  1.00 29.51  ? 957  LYS A O   1 
ATOM   829  C CB  . LYS A 1 107 ? -57.573  24.088 15.992  1.00 35.56  ? 957  LYS A CB  1 
ATOM   830  C CG  . LYS A 1 107 ? -57.693  23.164 17.194  1.00 42.60  ? 957  LYS A CG  1 
ATOM   831  C CD  . LYS A 1 107 ? -58.610  21.985 16.959  1.00 53.20  ? 957  LYS A CD  1 
ATOM   832  C CE  . LYS A 1 107 ? -58.110  21.042 15.887  1.00 57.67  ? 957  LYS A CE  1 
ATOM   833  N NZ  . LYS A 1 107 ? -58.884  21.171 14.630  1.00 61.83  ? 957  LYS A NZ  1 
ATOM   834  N N   . VAL A 1 108 ? -55.683  26.090 14.224  1.00 30.17  ? 958  VAL A N   1 
ATOM   835  C CA  . VAL A 1 108 ? -55.625  26.874 12.980  1.00 30.29  ? 958  VAL A CA  1 
ATOM   836  C C   . VAL A 1 108 ? -54.954  26.001 11.929  1.00 31.68  ? 958  VAL A C   1 
ATOM   837  O O   . VAL A 1 108 ? -54.055  25.225 12.257  1.00 29.13  ? 958  VAL A O   1 
ATOM   838  C CB  . VAL A 1 108 ? -54.882  28.227 13.146  1.00 31.10  ? 958  VAL A CB  1 
ATOM   839  C CG1 . VAL A 1 108 ? -53.427  28.008 13.500  1.00 27.95  ? 958  VAL A CG1 1 
ATOM   840  C CG2 . VAL A 1 108 ? -54.986  29.095 11.882  1.00 28.43  ? 958  VAL A CG2 1 
ATOM   841  N N   . TYR A 1 109 ? -55.414  26.070 10.676  1.00 28.51  ? 959  TYR A N   1 
ATOM   842  C CA  . TYR A 1 109 ? -54.760  25.245 9.659   1.00 31.58  ? 959  TYR A CA  1 
ATOM   843  C C   . TYR A 1 109 ? -55.020  25.772 8.252   1.00 34.95  ? 959  TYR A C   1 
ATOM   844  O O   . TYR A 1 109 ? -55.993  26.489 7.999   1.00 29.96  ? 959  TYR A O   1 
ATOM   845  C CB  . TYR A 1 109 ? -55.186  23.769 9.749   1.00 32.25  ? 959  TYR A CB  1 
ATOM   846  C CG  . TYR A 1 109 ? -56.678  23.496 9.698   1.00 33.53  ? 959  TYR A CG  1 
ATOM   847  C CD1 . TYR A 1 109 ? -57.450  23.500 10.852  1.00 33.27  ? 959  TYR A CD1 1 
ATOM   848  C CD2 . TYR A 1 109 ? -57.305  23.198 8.493   1.00 38.39  ? 959  TYR A CD2 1 
ATOM   849  C CE1 . TYR A 1 109 ? -58.813  23.236 10.805  1.00 40.99  ? 959  TYR A CE1 1 
ATOM   850  C CE2 . TYR A 1 109 ? -58.664  22.933 8.436   1.00 35.66  ? 959  TYR A CE2 1 
ATOM   851  C CZ  . TYR A 1 109 ? -59.412  22.954 9.593   1.00 35.72  ? 959  TYR A CZ  1 
ATOM   852  O OH  . TYR A 1 109 ? -60.764  22.691 9.535   1.00 39.48  ? 959  TYR A OH  1 
ATOM   853  N N   . GLN A 1 110 ? -54.114  25.412 7.340   1.00 32.83  ? 960  GLN A N   1 
ATOM   854  C CA  . GLN A 1 110 ? -54.310  25.703 5.925   1.00 32.44  ? 960  GLN A CA  1 
ATOM   855  C C   . GLN A 1 110 ? -55.576  25.026 5.425   1.00 30.68  ? 960  GLN A C   1 
ATOM   856  O O   . GLN A 1 110 ? -55.820  23.849 5.707   1.00 34.27  ? 960  GLN A O   1 
ATOM   857  C CB  . GLN A 1 110 ? -53.114  25.225 5.096   1.00 36.36  ? 960  GLN A CB  1 
ATOM   858  C CG  . GLN A 1 110 ? -53.151  25.676 3.632   1.00 36.69  ? 960  GLN A CG  1 
ATOM   859  C CD  . GLN A 1 110 ? -51.833  25.454 2.913   1.00 41.29  ? 960  GLN A CD  1 
ATOM   860  O OE1 . GLN A 1 110 ? -50.975  24.711 3.385   1.00 49.66  ? 960  GLN A OE1 1 
ATOM   861  N NE2 . GLN A 1 110 ? -51.657  26.118 1.775   1.00 52.10  ? 960  GLN A NE2 1 
ATOM   862  N N   . TRP A 1 111 ? -56.393  25.779 4.699   1.00 30.44  ? 961  TRP A N   1 
ATOM   863  C CA  . TRP A 1 111 ? -57.610  25.249 4.098   1.00 34.65  ? 961  TRP A CA  1 
ATOM   864  C C   . TRP A 1 111 ? -57.201  24.667 2.750   1.00 33.37  ? 961  TRP A C   1 
ATOM   865  O O   . TRP A 1 111 ? -56.930  25.412 1.803   1.00 36.83  ? 961  TRP A O   1 
ATOM   866  C CB  . TRP A 1 111 ? -58.658  26.347 3.950   1.00 30.99  ? 961  TRP A CB  1 
ATOM   867  C CG  . TRP A 1 111 ? -60.049  25.865 3.677   1.00 33.04  ? 961  TRP A CG  1 
ATOM   868  C CD1 . TRP A 1 111 ? -60.505  24.577 3.714   1.00 38.44  ? 961  TRP A CD1 1 
ATOM   869  C CD2 . TRP A 1 111 ? -61.169  26.677 3.317   1.00 30.91  ? 961  TRP A CD2 1 
ATOM   870  N NE1 . TRP A 1 111 ? -61.845  24.542 3.401   1.00 37.23  ? 961  TRP A NE1 1 
ATOM   871  C CE2 . TRP A 1 111 ? -62.275  25.820 3.153   1.00 34.65  ? 961  TRP A CE2 1 
ATOM   872  C CE3 . TRP A 1 111 ? -61.344  28.050 3.119   1.00 30.74  ? 961  TRP A CE3 1 
ATOM   873  C CZ2 . TRP A 1 111 ? -63.538  26.292 2.799   1.00 31.74  ? 961  TRP A CZ2 1 
ATOM   874  C CZ3 . TRP A 1 111 ? -62.596  28.516 2.769   1.00 35.25  ? 961  TRP A CZ3 1 
ATOM   875  C CH2 . TRP A 1 111 ? -63.676  27.640 2.612   1.00 31.21  ? 961  TRP A CH2 1 
ATOM   876  N N   . ASP A 1 112 ? -57.189  23.335 2.653   1.00 39.87  ? 962  ASP A N   1 
ATOM   877  C CA  . ASP A 1 112 ? -56.650  22.692 1.457   1.00 42.98  ? 962  ASP A CA  1 
ATOM   878  C C   . ASP A 1 112 ? -57.578  22.840 0.261   1.00 48.99  ? 962  ASP A C   1 
ATOM   879  O O   . ASP A 1 112 ? -57.113  23.028 -0.869  1.00 53.59  ? 962  ASP A O   1 
ATOM   880  C CB  . ASP A 1 112 ? -56.403  21.203 1.717   1.00 48.88  ? 962  ASP A CB  1 
ATOM   881  C CG  . ASP A 1 112 ? -55.199  20.946 2.597   1.00 51.81  ? 962  ASP A CG  1 
ATOM   882  O OD1 . ASP A 1 112 ? -54.146  21.574 2.362   1.00 52.13  ? 962  ASP A OD1 1 
ATOM   883  O OD2 . ASP A 1 112 ? -55.295  20.091 3.503   1.00 56.22  ? 962  ASP A OD2 1 
ATOM   884  N N   . ASP A 1 113 ? -58.887  22.766 0.483   1.00 43.35  ? 963  ASP A N   1 
ATOM   885  C CA  . ASP A 1 113 ? -59.872  22.736 -0.592  1.00 48.08  ? 963  ASP A CA  1 
ATOM   886  C C   . ASP A 1 113 ? -60.867  23.876 -0.416  1.00 39.48  ? 963  ASP A C   1 
ATOM   887  O O   . ASP A 1 113 ? -62.056  23.630 -0.171  1.00 41.65  ? 963  ASP A O   1 
ATOM   888  C CB  . ASP A 1 113 ? -60.587  21.388 -0.564  1.00 45.93  ? 963  ASP A CB  1 
ATOM   889  C CG  . ASP A 1 113 ? -61.049  21.018 0.840   1.00 61.04  ? 963  ASP A CG  1 
ATOM   890  O OD1 . ASP A 1 113 ? -60.486  21.574 1.811   1.00 56.91  ? 963  ASP A OD1 1 
ATOM   891  O OD2 . ASP A 1 113 ? -61.963  20.180 0.979   1.00 61.60  ? 963  ASP A OD2 1 
ATOM   892  N N   . PRO A 1 114 ? -60.443  25.124 -0.626  1.00 34.96  ? 964  PRO A N   1 
ATOM   893  C CA  . PRO A 1 114 ? -61.353  26.247 -0.369  1.00 33.88  ? 964  PRO A CA  1 
ATOM   894  C C   . PRO A 1 114 ? -62.606  26.126 -1.220  1.00 39.24  ? 964  PRO A C   1 
ATOM   895  O O   . PRO A 1 114 ? -62.537  25.903 -2.430  1.00 40.70  ? 964  PRO A O   1 
ATOM   896  C CB  . PRO A 1 114 ? -60.520  27.474 -0.761  1.00 35.29  ? 964  PRO A CB  1 
ATOM   897  C CG  . PRO A 1 114 ? -59.101  27.020 -0.659  1.00 43.73  ? 964  PRO A CG  1 
ATOM   898  C CD  . PRO A 1 114 ? -59.121  25.583 -1.087  1.00 38.55  ? 964  PRO A CD  1 
ATOM   899  N N   . ASP A 1 115 ? -63.754  26.317 -0.582  1.00 37.33  ? 965  ASP A N   1 
ATOM   900  C CA  . ASP A 1 115 ? -65.033  26.192 -1.270  1.00 34.13  ? 965  ASP A CA  1 
ATOM   901  C C   . ASP A 1 115 ? -65.647  27.570 -1.434  1.00 33.54  ? 965  ASP A C   1 
ATOM   902  O O   . ASP A 1 115 ? -66.161  28.131 -0.453  1.00 30.55  ? 965  ASP A O   1 
ATOM   903  C CB  . ASP A 1 115 ? -65.980  25.275 -0.492  1.00 33.50  ? 965  ASP A CB  1 
ATOM   904  C CG  . ASP A 1 115 ? -67.335  25.116 -1.170  1.00 36.35  ? 965  ASP A CG  1 
ATOM   905  O OD1 . ASP A 1 115 ? -67.511  25.603 -2.307  1.00 33.97  ? 965  ASP A OD1 1 
ATOM   906  O OD2 . ASP A 1 115 ? -68.237  24.510 -0.553  1.00 38.23  ? 965  ASP A OD2 1 
ATOM   907  N N   . PRO A 1 116 ? -65.650  28.144 -2.638  1.00 31.53  ? 966  PRO A N   1 
ATOM   908  C CA  . PRO A 1 116 ? -66.214  29.497 -2.789  1.00 31.00  ? 966  PRO A CA  1 
ATOM   909  C C   . PRO A 1 116 ? -67.683  29.574 -2.393  1.00 32.17  ? 966  PRO A C   1 
ATOM   910  O O   . PRO A 1 116 ? -68.147  30.626 -1.924  1.00 30.03  ? 966  PRO A O   1 
ATOM   911  C CB  . PRO A 1 116 ? -66.019  29.802 -4.284  1.00 34.76  ? 966  PRO A CB  1 
ATOM   912  C CG  . PRO A 1 116 ? -65.086  28.758 -4.818  1.00 37.75  ? 966  PRO A CG  1 
ATOM   913  C CD  . PRO A 1 116 ? -65.036  27.614 -3.869  1.00 33.96  ? 966  PRO A CD  1 
ATOM   914  N N   . ARG A 1 117 ? -68.412  28.461 -2.497  1.00 29.20  ? 967  ARG A N   1 
ATOM   915  C CA  . ARG A 1 117 ? -69.826  28.452 -2.144  1.00 29.40  ? 967  ARG A CA  1 
ATOM   916  C C   . ARG A 1 117 ? -70.062  28.668 -0.656  1.00 32.78  ? 967  ARG A C   1 
ATOM   917  O O   . ARG A 1 117 ? -71.167  29.065 -0.270  1.00 32.15  ? 967  ARG A O   1 
ATOM   918  C CB  . ARG A 1 117 ? -70.466  27.144 -2.604  1.00 30.40  ? 967  ARG A CB  1 
ATOM   919  C CG  . ARG A 1 117 ? -70.530  26.998 -4.130  1.00 28.70  ? 967  ARG A CG  1 
ATOM   920  C CD  . ARG A 1 117 ? -71.605  27.869 -4.800  1.00 30.33  ? 967  ARG A CD  1 
ATOM   921  N NE  . ARG A 1 117 ? -71.210  29.267 -4.914  1.00 29.72  ? 967  ARG A NE  1 
ATOM   922  C CZ  . ARG A 1 117 ? -70.266  29.725 -5.723  1.00 33.77  ? 967  ARG A CZ  1 
ATOM   923  N NH1 . ARG A 1 117 ? -69.640  28.940 -6.583  1.00 31.86  ? 967  ARG A NH1 1 
ATOM   924  N NH2 . ARG A 1 117 ? -69.955  31.018 -5.685  1.00 36.34  ? 967  ARG A NH2 1 
ATOM   925  N N   . LEU A 1 118 ? -69.057  28.411 0.187   1.00 32.36  ? 968  LEU A N   1 
ATOM   926  C CA  . LEU A 1 118 ? -69.222  28.668 1.613   1.00 31.95  ? 968  LEU A CA  1 
ATOM   927  C C   . LEU A 1 118 ? -69.532  30.134 1.861   1.00 30.29  ? 968  LEU A C   1 
ATOM   928  O O   . LEU A 1 118 ? -70.168  30.479 2.866   1.00 33.22  ? 968  LEU A O   1 
ATOM   929  C CB  . LEU A 1 118 ? -67.964  28.252 2.377   1.00 32.37  ? 968  LEU A CB  1 
ATOM   930  C CG  . LEU A 1 118 ? -68.017  28.483 3.888   1.00 32.19  ? 968  LEU A CG  1 
ATOM   931  C CD1 . LEU A 1 118 ? -69.127  27.647 4.510   1.00 35.62  ? 968  LEU A CD1 1 
ATOM   932  C CD2 . LEU A 1 118 ? -66.681  28.171 4.524   1.00 30.21  ? 968  LEU A CD2 1 
ATOM   933  N N   . PHE A 1 119 ? -69.112  31.005 0.945   1.00 27.98  ? 969  PHE A N   1 
ATOM   934  C CA  . PHE A 1 119 ? -69.264  32.438 1.122   1.00 27.95  ? 969  PHE A CA  1 
ATOM   935  C C   . PHE A 1 119 ? -70.533  32.972 0.472   1.00 30.10  ? 969  PHE A C   1 
ATOM   936  O O   . PHE A 1 119 ? -70.748  34.190 0.459   1.00 31.28  ? 969  PHE A O   1 
ATOM   937  C CB  . PHE A 1 119 ? -68.003  33.128 0.613   1.00 28.43  ? 969  PHE A CB  1 
ATOM   938  C CG  . PHE A 1 119 ? -66.762  32.613 1.285   1.00 31.01  ? 969  PHE A CG  1 
ATOM   939  C CD1 . PHE A 1 119 ? -66.464  32.968 2.593   1.00 29.77  ? 969  PHE A CD1 1 
ATOM   940  C CD2 . PHE A 1 119 ? -65.961  31.676 0.654   1.00 31.56  ? 969  PHE A CD2 1 
ATOM   941  C CE1 . PHE A 1 119 ? -65.342  32.457 3.227   1.00 28.99  ? 969  PHE A CE1 1 
ATOM   942  C CE2 . PHE A 1 119 ? -64.842  31.160 1.283   1.00 31.38  ? 969  PHE A CE2 1 
ATOM   943  C CZ  . PHE A 1 119 ? -64.531  31.552 2.570   1.00 32.30  ? 969  PHE A CZ  1 
ATOM   944  N N   . ASP A 1 120 ? -71.399  32.083 -0.017  1.00 32.02  ? 970  ASP A N   1 
ATOM   945  C CA  . ASP A 1 120 ? -72.693  32.513 -0.518  1.00 32.82  ? 970  ASP A CA  1 
ATOM   946  C C   . ASP A 1 120 ? -73.505  33.008 0.663   1.00 29.59  ? 970  ASP A C   1 
ATOM   947  O O   . ASP A 1 120 ? -73.410  32.470 1.769   1.00 34.42  ? 970  ASP A O   1 
ATOM   948  C CB  . ASP A 1 120 ? -73.454  31.359 -1.178  1.00 33.54  ? 970  ASP A CB  1 
ATOM   949  C CG  . ASP A 1 120 ? -72.870  30.927 -2.503  1.00 34.46  ? 970  ASP A CG  1 
ATOM   950  O OD1 . ASP A 1 120 ? -72.011  31.642 -3.054  1.00 34.38  ? 970  ASP A OD1 1 
ATOM   951  O OD2 . ASP A 1 120 ? -73.286  29.856 -2.995  1.00 39.32  ? 970  ASP A OD2 1 
ATOM   952  N N   . HIS A 1 121 ? -74.262  34.048 0.449   1.00 31.97  ? 971  HIS A N   1 
ATOM   953  C CA  . HIS A 1 121 ? -74.988  34.612 1.571   1.00 35.33  ? 971  HIS A CA  1 
ATOM   954  C C   . HIS A 1 121 ? -76.191  33.737 1.901   1.00 38.22  ? 971  HIS A C   1 
ATOM   955  O O   . HIS A 1 121 ? -76.939  33.355 0.995   1.00 39.00  ? 971  HIS A O   1 
ATOM   956  C CB  . HIS A 1 121 ? -75.395  36.038 1.262   1.00 37.47  ? 971  HIS A CB  1 
ATOM   957  C CG  . HIS A 1 121 ? -74.225  36.966 1.172   1.00 44.85  ? 971  HIS A CG  1 
ATOM   958  N ND1 . HIS A 1 121 ? -74.347  38.302 0.860   1.00 47.87  ? 971  HIS A ND1 1 
ATOM   959  C CD2 . HIS A 1 121 ? -72.902  36.740 1.353   1.00 41.67  ? 971  HIS A CD2 1 
ATOM   960  C CE1 . HIS A 1 121 ? -73.148  38.859 0.852   1.00 50.36  ? 971  HIS A CE1 1 
ATOM   961  N NE2 . HIS A 1 121 ? -72.255  37.933 1.148   1.00 47.48  ? 971  HIS A NE2 1 
ATOM   962  N N   . PRO A 1 122 ? -76.384  33.371 3.167   1.00 36.77  ? 972  PRO A N   1 
ATOM   963  C CA  . PRO A 1 122 ? -77.536  32.539 3.526   1.00 42.08  ? 972  PRO A CA  1 
ATOM   964  C C   . PRO A 1 122 ? -78.835  33.259 3.207   1.00 39.50  ? 972  PRO A C   1 
ATOM   965  O O   . PRO A 1 122 ? -78.920  34.487 3.267   1.00 41.70  ? 972  PRO A O   1 
ATOM   966  C CB  . PRO A 1 122 ? -77.364  32.332 5.036   1.00 41.07  ? 972  PRO A CB  1 
ATOM   967  C CG  . PRO A 1 122 ? -75.895  32.537 5.270   1.00 48.89  ? 972  PRO A CG  1 
ATOM   968  C CD  . PRO A 1 122 ? -75.531  33.651 4.334   1.00 39.13  ? 972  PRO A CD  1 
ATOM   969  N N   . GLU A 1 123 ? -79.856  32.479 2.863   1.00 41.04  ? 973  GLU A N   1 
ATOM   970  C CA  . GLU A 1 123 ? -81.138  33.016 2.427   1.00 45.44  ? 973  GLU A CA  1 
ATOM   971  C C   . GLU A 1 123 ? -82.259  32.447 3.285   1.00 44.55  ? 973  GLU A C   1 
ATOM   972  O O   . GLU A 1 123 ? -82.335  31.232 3.485   1.00 49.93  ? 973  GLU A O   1 
ATOM   973  C CB  . GLU A 1 123 ? -81.393  32.684 0.956   1.00 47.35  ? 973  GLU A CB  1 
ATOM   974  C CG  . GLU A 1 123 ? -80.520  33.443 -0.019  1.00 53.68  ? 973  GLU A CG  1 
ATOM   975  C CD  . GLU A 1 123 ? -80.852  33.110 -1.456  1.00 59.74  ? 973  GLU A CD  1 
ATOM   976  O OE1 . GLU A 1 123 ? -81.734  32.253 -1.677  1.00 55.01  ? 973  GLU A OE1 1 
ATOM   977  O OE2 . GLU A 1 123 ? -80.234  33.702 -2.365  1.00 65.13  ? 973  GLU A OE2 1 
ATOM   978  N N   . SER A 1 124 ? -83.137  33.320 3.774   1.00 49.15  ? 974  SER A N   1 
ATOM   979  C CA  . SER A 1 124 ? -84.324  32.885 4.505   1.00 51.12  ? 974  SER A CA  1 
ATOM   980  C C   . SER A 1 124 ? -85.245  32.110 3.551   1.00 60.46  ? 974  SER A C   1 
ATOM   981  O O   . SER A 1 124 ? -85.091  32.208 2.322   1.00 57.77  ? 974  SER A O   1 
ATOM   982  C CB  . SER A 1 124 ? -85.058  34.108 5.092   1.00 50.45  ? 974  SER A CB  1 
ATOM   983  O OG  . SER A 1 124 ? -84.493  34.566 6.293   1.00 55.83  ? 974  SER A OG  1 
ATOM   984  N N   . PRO A 1 125 ? -86.264  31.418 4.061   1.00 66.41  ? 975  PRO A N   1 
ATOM   985  C CA  . PRO A 1 125 ? -87.231  30.758 3.168   1.00 66.18  ? 975  PRO A CA  1 
ATOM   986  C C   . PRO A 1 125 ? -88.083  31.729 2.375   1.00 68.88  ? 975  PRO A C   1 
ATOM   987  O O   . PRO A 1 125 ? -88.513  31.402 1.262   1.00 73.90  ? 975  PRO A O   1 
ATOM   988  C CB  . PRO A 1 125 ? -88.100  29.955 4.141   1.00 66.00  ? 975  PRO A CB  1 
ATOM   989  C CG  . PRO A 1 125 ? -87.236  29.751 5.323   1.00 66.25  ? 975  PRO A CG  1 
ATOM   990  C CD  . PRO A 1 125 ? -86.465  31.025 5.460   1.00 59.72  ? 975  PRO A CD  1 
ATOM   991  N N   . THR A 1 126 ? -88.379  32.890 2.934   1.00 67.02  ? 976  THR A N   1 
ATOM   992  C CA  . THR A 1 126 ? -89.207  33.899 2.299   1.00 72.02  ? 976  THR A CA  1 
ATOM   993  C C   . THR A 1 126 ? -88.521  35.246 2.465   1.00 72.09  ? 976  THR A C   1 
ATOM   994  O O   . THR A 1 126 ? -87.671  35.412 3.346   1.00 67.45  ? 976  THR A O   1 
ATOM   995  C CB  . THR A 1 126 ? -90.617  33.908 2.918   1.00 71.70  ? 976  THR A CB  1 
ATOM   996  O OG1 . THR A 1 126 ? -91.542  34.554 2.035   1.00 76.89  ? 976  THR A OG1 1 
ATOM   997  C CG2 . THR A 1 126 ? -90.625  34.618 4.258   1.00 66.88  ? 976  THR A CG2 1 
ATOM   998  N N   . PRO A 1 127 ? -88.839  36.226 1.607   1.00 77.05  ? 977  PRO A N   1 
ATOM   999  C CA  . PRO A 1 127 ? -88.201  37.549 1.704   1.00 75.59  ? 977  PRO A CA  1 
ATOM   1000 C C   . PRO A 1 127 ? -88.429  38.234 3.030   1.00 74.89  ? 977  PRO A C   1 
ATOM   1001 O O   . PRO A 1 127 ? -89.081  37.684 3.919   1.00 77.58  ? 977  PRO A O   1 
ATOM   1002 C CB  . PRO A 1 127 ? -88.884  38.347 0.594   1.00 76.04  ? 977  PRO A CB  1 
ATOM   1003 C CG  . PRO A 1 127 ? -89.260  37.414 -0.236  1.00 72.68  ? 977  PRO A CG  1 
ATOM   1004 C CD  . PRO A 1 127 ? -89.703  36.184 0.433   1.00 74.95  ? 977  PRO A CD  1 
ATOM   1005 N N   . ASN A 1 128 ? -87.938  39.454 3.151   1.00 74.68  ? 978  ASN A N   1 
ATOM   1006 C CA  . ASN A 1 128 ? -88.045  40.174 4.410   1.00 79.70  ? 978  ASN A CA  1 
ATOM   1007 C C   . ASN A 1 128 ? -89.502  40.541 4.681   1.00 77.02  ? 978  ASN A C   1 
ATOM   1008 O O   . ASN A 1 128 ? -90.150  41.160 3.824   1.00 74.50  ? 978  ASN A O   1 
ATOM   1009 C CB  . ASN A 1 128 ? -87.139  41.404 4.371   1.00 82.68  ? 978  ASN A CB  1 
ATOM   1010 C CG  . ASN A 1 128 ? -86.902  42.004 5.744   1.00 85.97  ? 978  ASN A CG  1 
ATOM   1011 O OD1 . ASN A 1 128 ? -87.011  41.321 6.761   1.00 82.56  ? 978  ASN A OD1 1 
ATOM   1012 N ND2 . ASN A 1 128 ? -86.512  43.272 5.774   1.00 85.27  ? 978  ASN A ND2 1 
ATOM   1013 N N   . PRO A 1 129 ? -90.060  40.157 5.837   1.00 79.91  ? 979  PRO A N   1 
ATOM   1014 C CA  . PRO A 1 129 ? -91.490  40.390 6.101   1.00 69.55  ? 979  PRO A CA  1 
ATOM   1015 C C   . PRO A 1 129 ? -91.821  41.799 6.550   1.00 72.59  ? 979  PRO A C   1 
ATOM   1016 O O   . PRO A 1 129 ? -92.972  42.227 6.396   1.00 68.81  ? 979  PRO A O   1 
ATOM   1017 C CB  . PRO A 1 129 ? -91.809  39.376 7.219   1.00 64.43  ? 979  PRO A CB  1 
ATOM   1018 C CG  . PRO A 1 129 ? -90.547  38.524 7.358   1.00 71.40  ? 979  PRO A CG  1 
ATOM   1019 C CD  . PRO A 1 129 ? -89.436  39.408 6.933   1.00 75.55  ? 979  PRO A CD  1 
ATOM   1020 N N   . THR A 1 130 ? -90.872  42.528 7.113   1.00 80.17  ? 980  THR A N   1 
ATOM   1021 C CA  . THR A 1 130 ? -91.076  43.933 7.413   1.00 80.09  ? 980  THR A CA  1 
ATOM   1022 C C   . THR A 1 130 ? -90.172  44.765 6.512   1.00 83.50  ? 980  THR A C   1 
ATOM   1023 O O   . THR A 1 130 ? -89.045  44.357 6.215   1.00 87.03  ? 980  THR A O   1 
ATOM   1024 C CB  . THR A 1 130 ? -90.806  44.222 8.886   1.00 74.23  ? 980  THR A CB  1 
ATOM   1025 O OG1 . THR A 1 130 ? -91.674  43.415 9.697   1.00 69.28  ? 980  THR A OG1 1 
ATOM   1026 C CG2 . THR A 1 130 ? -91.092  45.670 9.156   1.00 66.00  ? 980  THR A CG2 1 
ATOM   1027 N N   . GLU A 1 131 ? -90.677  45.912 6.047   1.00 85.36  ? 981  GLU A N   1 
ATOM   1028 C CA  . GLU A 1 131 ? -89.961  46.717 5.056   1.00 85.98  ? 981  GLU A CA  1 
ATOM   1029 C C   . GLU A 1 131 ? -88.595  47.140 5.586   1.00 89.08  ? 981  GLU A C   1 
ATOM   1030 O O   . GLU A 1 131 ? -88.522  47.775 6.647   1.00 91.80  ? 981  GLU A O   1 
ATOM   1031 C CB  . GLU A 1 131 ? -90.748  47.965 4.655   1.00 84.28  ? 981  GLU A CB  1 
ATOM   1032 C CG  . GLU A 1 131 ? -92.059  47.701 3.955   1.00 74.60  ? 981  GLU A CG  1 
ATOM   1033 C CD  . GLU A 1 131 ? -92.745  48.980 3.497   1.00 73.48  ? 981  GLU A CD  1 
ATOM   1034 O OE1 . GLU A 1 131 ? -93.032  49.844 4.351   1.00 79.51  ? 981  GLU A OE1 1 
ATOM   1035 O OE2 . GLU A 1 131 ? -93.010  49.112 2.282   1.00 63.39  ? 981  GLU A OE2 1 
ATOM   1036 N N   . PRO A 1 132 ? -87.504  46.836 4.881   1.00 92.58  ? 982  PRO A N   1 
ATOM   1037 C CA  . PRO A 1 132 ? -86.163  47.156 5.394   1.00 88.46  ? 982  PRO A CA  1 
ATOM   1038 C C   . PRO A 1 132 ? -85.814  48.629 5.204   1.00 81.66  ? 982  PRO A C   1 
ATOM   1039 O O   . PRO A 1 132 ? -85.902  49.163 4.097   1.00 82.60  ? 982  PRO A O   1 
ATOM   1040 C CB  . PRO A 1 132 ? -85.251  46.253 4.558   1.00 84.96  ? 982  PRO A CB  1 
ATOM   1041 C CG  . PRO A 1 132 ? -85.973  46.171 3.234   1.00 89.25  ? 982  PRO A CG  1 
ATOM   1042 C CD  . PRO A 1 132 ? -87.446  46.121 3.591   1.00 88.14  ? 982  PRO A CD  1 
ATOM   1043 N N   . LEU A 1 133 ? -85.397  49.284 6.291   1.00 79.05  ? 983  LEU A N   1 
ATOM   1044 C CA  . LEU A 1 133 ? -85.022  50.701 6.275   1.00 79.96  ? 983  LEU A CA  1 
ATOM   1045 C C   . LEU A 1 133 ? -83.543  50.829 6.620   1.00 72.45  ? 983  LEU A C   1 
ATOM   1046 O O   . LEU A 1 133 ? -83.161  50.729 7.790   1.00 73.61  ? 983  LEU A O   1 
ATOM   1047 C CB  . LEU A 1 133 ? -85.871  51.517 7.245   1.00 84.26  ? 983  LEU A CB  1 
ATOM   1048 C CG  . LEU A 1 133 ? -87.238  51.975 6.739   1.00 81.16  ? 983  LEU A CG  1 
ATOM   1049 C CD1 . LEU A 1 133 ? -88.175  50.805 6.570   1.00 83.73  ? 983  LEU A CD1 1 
ATOM   1050 C CD2 . LEU A 1 133 ? -87.840  53.003 7.677   1.00 79.04  ? 983  LEU A CD2 1 
ATOM   1051 N N   . PHE A 1 134 ? -82.714  51.087 5.617   1.00 67.41  ? 984  PHE A N   1 
ATOM   1052 C CA  . PHE A 1 134 ? -81.279  51.057 5.845   1.00 58.99  ? 984  PHE A CA  1 
ATOM   1053 C C   . PHE A 1 134 ? -80.814  52.246 6.678   1.00 59.08  ? 984  PHE A C   1 
ATOM   1054 O O   . PHE A 1 134 ? -81.218  53.391 6.451   1.00 62.11  ? 984  PHE A O   1 
ATOM   1055 C CB  . PHE A 1 134 ? -80.524  51.027 4.514   1.00 60.12  ? 984  PHE A CB  1 
ATOM   1056 C CG  . PHE A 1 134 ? -80.081  49.649 4.100   1.00 61.16  ? 984  PHE A CG  1 
ATOM   1057 C CD1 . PHE A 1 134 ? -80.996  48.616 3.983   1.00 65.60  ? 984  PHE A CD1 1 
ATOM   1058 C CD2 . PHE A 1 134 ? -78.749  49.388 3.823   1.00 60.36  ? 984  PHE A CD2 1 
ATOM   1059 C CE1 . PHE A 1 134 ? -80.590  47.348 3.602   1.00 65.11  ? 984  PHE A CE1 1 
ATOM   1060 C CE2 . PHE A 1 134 ? -78.336  48.122 3.442   1.00 57.94  ? 984  PHE A CE2 1 
ATOM   1061 C CZ  . PHE A 1 134 ? -79.258  47.101 3.332   1.00 57.54  ? 984  PHE A CZ  1 
ATOM   1062 N N   . LEU A 1 135 ? -79.927  51.959 7.628   1.00 47.67  ? 985  LEU A N   1 
ATOM   1063 C CA  . LEU A 1 135 ? -79.318  52.968 8.479   1.00 46.27  ? 985  LEU A CA  1 
ATOM   1064 C C   . LEU A 1 135 ? -78.002  53.369 7.838   1.00 46.96  ? 985  LEU A C   1 
ATOM   1065 O O   . LEU A 1 135 ? -77.275  52.522 7.311   1.00 44.67  ? 985  LEU A O   1 
ATOM   1066 C CB  . LEU A 1 135 ? -79.061  52.449 9.897   1.00 52.07  ? 985  LEU A CB  1 
ATOM   1067 C CG  . LEU A 1 135 ? -80.229  51.945 10.736  1.00 54.93  ? 985  LEU A CG  1 
ATOM   1068 C CD1 . LEU A 1 135 ? -79.774  50.862 11.698  1.00 53.49  ? 985  LEU A CD1 1 
ATOM   1069 C CD2 . LEU A 1 135 ? -80.813  53.123 11.501  1.00 54.25  ? 985  LEU A CD2 1 
ATOM   1070 N N   . ALA A 1 136 ? -77.725  54.667 7.844   1.00 42.08  ? 986  ALA A N   1 
ATOM   1071 C CA  . ALA A 1 136 ? -76.468  55.168 7.321   1.00 44.26  ? 986  ALA A CA  1 
ATOM   1072 C C   . ALA A 1 136 ? -75.352  54.996 8.350   1.00 41.56  ? 986  ALA A C   1 
ATOM   1073 O O   . ALA A 1 136 ? -75.586  54.675 9.517   1.00 39.69  ? 986  ALA A O   1 
ATOM   1074 C CB  . ALA A 1 136 ? -76.607  56.632 6.913   1.00 51.74  ? 986  ALA A CB  1 
ATOM   1075 N N   . GLN A 1 137 ? -74.118  55.212 7.886   1.00 42.27  ? 987  GLN A N   1 
ATOM   1076 C CA  . GLN A 1 137 ? -72.929  54.983 8.702   1.00 39.09  ? 987  GLN A CA  1 
ATOM   1077 C C   . GLN A 1 137 ? -73.018  55.676 10.061  1.00 43.23  ? 987  GLN A C   1 
ATOM   1078 O O   . GLN A 1 137 ? -72.899  55.032 11.114  1.00 38.24  ? 987  GLN A O   1 
ATOM   1079 C CB  . GLN A 1 137 ? -71.698  55.454 7.929   1.00 38.51  ? 987  GLN A CB  1 
ATOM   1080 C CG  . GLN A 1 137 ? -70.419  55.472 8.729   1.00 39.18  ? 987  GLN A CG  1 
ATOM   1081 C CD  . GLN A 1 137 ? -69.208  55.666 7.847   1.00 48.34  ? 987  GLN A CD  1 
ATOM   1082 O OE1 . GLN A 1 137 ? -68.517  54.708 7.502   1.00 54.13  ? 987  GLN A OE1 1 
ATOM   1083 N NE2 . GLN A 1 137 ? -68.952  56.910 7.462   1.00 55.83  ? 987  GLN A NE2 1 
ATOM   1084 N N   . ALA A 1 138 ? -73.249  56.994 10.052  1.00 41.13  ? 988  ALA A N   1 
ATOM   1085 C CA  . ALA A 1 138 ? -73.275  57.748 11.302  1.00 43.94  ? 988  ALA A CA  1 
ATOM   1086 C C   . ALA A 1 138 ? -74.347  57.223 12.250  1.00 41.26  ? 988  ALA A C   1 
ATOM   1087 O O   . ALA A 1 138 ? -74.136  57.199 13.468  1.00 42.98  ? 988  ALA A O   1 
ATOM   1088 C CB  . ALA A 1 138 ? -73.475  59.238 11.022  1.00 45.36  ? 988  ALA A CB  1 
ATOM   1089 N N   . GLU A 1 139 ? -75.488  56.768 11.717  1.00 38.37  ? 989  GLU A N   1 
ATOM   1090 C CA  . GLU A 1 139 ? -76.526  56.202 12.582  1.00 40.50  ? 989  GLU A CA  1 
ATOM   1091 C C   . GLU A 1 139 ? -76.083  54.866 13.186  1.00 36.68  ? 989  GLU A C   1 
ATOM   1092 O O   . GLU A 1 139 ? -76.330  54.581 14.378  1.00 36.19  ? 989  GLU A O   1 
ATOM   1093 C CB  . GLU A 1 139 ? -77.827  56.005 11.796  1.00 44.97  ? 989  GLU A CB  1 
ATOM   1094 C CG  . GLU A 1 139 ? -78.427  57.249 11.165  1.00 55.82  ? 989  GLU A CG  1 
ATOM   1095 C CD  . GLU A 1 139 ? -79.562  56.919 10.208  1.00 58.93  ? 989  GLU A CD  1 
ATOM   1096 O OE1 . GLU A 1 139 ? -79.279  56.572 9.043   1.00 50.28  ? 989  GLU A OE1 1 
ATOM   1097 O OE2 . GLU A 1 139 ? -80.740  57.003 10.622  1.00 59.41  ? 989  GLU A OE2 1 
ATOM   1098 N N   . VAL A 1 140 ? -75.401  54.044 12.381  1.00 37.03  ? 990  VAL A N   1 
ATOM   1099 C CA  . VAL A 1 140 ? -74.892  52.767 12.874  1.00 35.39  ? 990  VAL A CA  1 
ATOM   1100 C C   . VAL A 1 140 ? -73.947  52.993 14.045  1.00 30.33  ? 990  VAL A C   1 
ATOM   1101 O O   . VAL A 1 140 ? -74.069  52.362 15.109  1.00 34.19  ? 990  VAL A O   1 
ATOM   1102 C CB  . VAL A 1 140 ? -74.198  51.989 11.742  1.00 33.32  ? 990  VAL A CB  1 
ATOM   1103 C CG1 . VAL A 1 140 ? -73.396  50.824 12.314  1.00 31.83  ? 990  VAL A CG1 1 
ATOM   1104 C CG2 . VAL A 1 140 ? -75.215  51.517 10.717  1.00 32.57  ? 990  VAL A CG2 1 
ATOM   1105 N N   . TYR A 1 141 ? -73.014  53.927 13.887  1.00 31.88  ? 991  TYR A N   1 
ATOM   1106 C CA  . TYR A 1 141 ? -72.002  54.064 14.921  1.00 33.74  ? 991  TYR A CA  1 
ATOM   1107 C C   . TYR A 1 141 ? -72.525  54.842 16.102  1.00 40.95  ? 991  TYR A C   1 
ATOM   1108 O O   . TYR A 1 141 ? -72.029  54.653 17.215  1.00 36.31  ? 991  TYR A O   1 
ATOM   1109 C CB  . TYR A 1 141 ? -70.718  54.645 14.337  1.00 35.25  ? 991  TYR A CB  1 
ATOM   1110 C CG  . TYR A 1 141 ? -70.056  53.541 13.571  1.00 34.09  ? 991  TYR A CG  1 
ATOM   1111 C CD1 . TYR A 1 141 ? -69.361  52.544 14.240  1.00 34.20  ? 991  TYR A CD1 1 
ATOM   1112 C CD2 . TYR A 1 141 ? -70.227  53.419 12.202  1.00 31.77  ? 991  TYR A CD2 1 
ATOM   1113 C CE1 . TYR A 1 141 ? -68.798  51.493 13.561  1.00 31.72  ? 991  TYR A CE1 1 
ATOM   1114 C CE2 . TYR A 1 141 ? -69.666  52.370 11.511  1.00 31.58  ? 991  TYR A CE2 1 
ATOM   1115 C CZ  . TYR A 1 141 ? -68.955  51.408 12.196  1.00 28.49  ? 991  TYR A CZ  1 
ATOM   1116 O OH  . TYR A 1 141 ? -68.388  50.355 11.519  1.00 29.13  ? 991  TYR A OH  1 
ATOM   1117 N N   . LYS A 1 142 ? -73.542  55.672 15.904  1.00 38.99  ? 992  LYS A N   1 
ATOM   1118 C CA  . LYS A 1 142 ? -74.268  56.192 17.063  1.00 36.21  ? 992  LYS A CA  1 
ATOM   1119 C C   . LYS A 1 142 ? -74.794  55.108 17.927  1.00 31.42  ? 992  LYS A C   1 
ATOM   1120 O O   . LYS A 1 142 ? -74.777  55.135 19.179  1.00 39.04  ? 992  LYS A O   1 
ATOM   1121 C CB  . LYS A 1 142 ? -75.324  57.207 16.569  1.00 40.39  ? 992  LYS A CB  1 
ATOM   1122 C CG  . LYS A 1 142 ? -76.233  57.771 17.644  1.00 48.69  ? 992  LYS A CG  1 
ATOM   1123 C CD  . LYS A 1 142 ? -76.094  59.304 17.719  1.00 48.86  ? 992  LYS A CD  1 
ATOM   1124 C CE  . LYS A 1 142 ? -77.158  59.866 18.648  1.00 48.69  ? 992  LYS A CE  1 
ATOM   1125 N NZ  . LYS A 1 142 ? -77.637  61.199 18.189  1.00 55.67  ? 992  LYS A NZ  1 
ATOM   1126 N N   . GLU A 1 143 ? -75.534  54.207 17.294  1.00 35.06  ? 993  GLU A N   1 
ATOM   1127 C CA  . GLU A 1 143 ? -76.208  53.136 18.060  1.00 36.19  ? 993  GLU A CA  1 
ATOM   1128 C C   . GLU A 1 143 ? -75.179  52.302 18.805  1.00 40.74  ? 993  GLU A C   1 
ATOM   1129 O O   . GLU A 1 143 ? -75.411  51.950 19.946  1.00 37.83  ? 993  GLU A O   1 
ATOM   1130 C CB  . GLU A 1 143 ? -76.974  52.227 17.114  1.00 39.07  ? 993  GLU A CB  1 
ATOM   1131 C CG  . GLU A 1 143 ? -78.417  52.631 16.914  1.00 50.62  ? 993  GLU A CG  1 
ATOM   1132 C CD  . GLU A 1 143 ? -79.209  52.627 18.208  1.00 61.74  ? 993  GLU A CD  1 
ATOM   1133 O OE1 . GLU A 1 143 ? -79.230  51.581 18.881  1.00 59.44  ? 993  GLU A OE1 1 
ATOM   1134 O OE2 . GLU A 1 143 ? -79.794  53.669 18.539  1.00 69.20  ? 993  GLU A OE2 1 
ATOM   1135 N N   . LEU A 1 144 ? -74.118  51.934 18.111  1.00 34.11  ? 994  LEU A N   1 
ATOM   1136 C CA  . LEU A 1 144 ? -73.077  51.233 18.743  1.00 34.35  ? 994  LEU A CA  1 
ATOM   1137 C C   . LEU A 1 144 ? -72.442  52.026 19.885  1.00 31.75  ? 994  LEU A C   1 
ATOM   1138 O O   . LEU A 1 144 ? -72.223  51.470 20.969  1.00 34.97  ? 994  LEU A O   1 
ATOM   1139 C CB  . LEU A 1 144 ? -72.027  50.823 17.706  1.00 28.41  ? 994  LEU A CB  1 
ATOM   1140 C CG  . LEU A 1 144 ? -72.510  49.634 16.860  1.00 30.89  ? 994  LEU A CG  1 
ATOM   1141 C CD1 . LEU A 1 144 ? -71.613  49.393 15.655  1.00 33.24  ? 994  LEU A CD1 1 
ATOM   1142 C CD2 . LEU A 1 144 ? -72.689  48.355 17.673  1.00 34.43  ? 994  LEU A CD2 1 
ATOM   1143 N N   . ARG A 1 145 ? -72.124  53.313 19.670  1.00 37.00  ? 995  ARG A N   1 
ATOM   1144 C CA  . ARG A 1 145 ? -71.560  54.161 20.721  1.00 36.20  ? 995  ARG A CA  1 
ATOM   1145 C C   . ARG A 1 145 ? -72.437  54.202 21.958  1.00 43.29  ? 995  ARG A C   1 
ATOM   1146 O O   . ARG A 1 145 ? -71.931  54.191 23.087  1.00 39.18  ? 995  ARG A O   1 
ATOM   1147 C CB  . ARG A 1 145 ? -71.365  55.590 20.218  1.00 40.33  ? 995  ARG A CB  1 
ATOM   1148 C CG  . ARG A 1 145 ? -70.247  56.325 20.939  1.00 41.22  ? 995  ARG A CG  1 
ATOM   1149 C CD  . ARG A 1 145 ? -69.775  57.535 20.160  1.00 47.62  ? 995  ARG A CD  1 
ATOM   1150 N NE  . ARG A 1 145 ? -70.845  58.101 19.346  1.00 50.19  ? 995  ARG A NE  1 
ATOM   1151 C CZ  . ARG A 1 145 ? -70.814  58.209 18.025  1.00 47.79  ? 995  ARG A CZ  1 
ATOM   1152 N NH1 . ARG A 1 145 ? -69.778  57.787 17.320  1.00 46.44  ? 995  ARG A NH1 1 
ATOM   1153 N NH2 . ARG A 1 145 ? -71.847  58.765 17.397  1.00 42.75  ? 995  ARG A NH2 1 
ATOM   1154 N N   . LEU A 1 146 ? -73.754  54.297 21.768  1.00 42.37  ? 996  LEU A N   1 
ATOM   1155 C CA  . LEU A 1 146 ? -74.646  54.399 22.915  1.00 42.38  ? 996  LEU A CA  1 
ATOM   1156 C C   . LEU A 1 146 ? -74.488  53.199 23.837  1.00 42.44  ? 996  LEU A C   1 
ATOM   1157 O O   . LEU A 1 146 ? -74.562  53.333 25.063  1.00 46.34  ? 996  LEU A O   1 
ATOM   1158 C CB  . LEU A 1 146 ? -76.096  54.513 22.451  1.00 39.77  ? 996  LEU A CB  1 
ATOM   1159 C CG  . LEU A 1 146 ? -76.534  55.763 21.692  1.00 41.74  ? 996  LEU A CG  1 
ATOM   1160 C CD1 . LEU A 1 146 ? -77.917  55.530 21.110  1.00 51.99  ? 996  LEU A CD1 1 
ATOM   1161 C CD2 . LEU A 1 146 ? -76.510  56.999 22.569  1.00 44.40  ? 996  LEU A CD2 1 
ATOM   1162 N N   . ARG A 1 147 ? -74.265  52.019 23.264  1.00 41.09  ? 997  ARG A N   1 
ATOM   1163 C CA  . ARG A 1 147 ? -74.125  50.790 24.031  1.00 37.22  ? 997  ARG A CA  1 
ATOM   1164 C C   . ARG A 1 147 ? -72.701  50.507 24.502  1.00 44.00  ? 997  ARG A C   1 
ATOM   1165 O O   . ARG A 1 147 ? -72.467  49.454 25.101  1.00 45.00  ? 997  ARG A O   1 
ATOM   1166 C CB  . ARG A 1 147 ? -74.659  49.605 23.217  1.00 38.52  ? 997  ARG A CB  1 
ATOM   1167 C CG  . ARG A 1 147 ? -76.013  49.875 22.573  1.00 45.79  ? 997  ARG A CG  1 
ATOM   1168 C CD  . ARG A 1 147 ? -76.242  49.123 21.264  1.00 44.43  ? 997  ARG A CD  1 
ATOM   1169 N NE  . ARG A 1 147 ? -75.983  47.691 21.365  1.00 49.41  ? 997  ARG A NE  1 
ATOM   1170 C CZ  . ARG A 1 147 ? -76.370  46.801 20.461  1.00 53.44  ? 997  ARG A CZ  1 
ATOM   1171 N NH1 . ARG A 1 147 ? -76.991  47.169 19.352  1.00 44.73  ? 997  ARG A NH1 1 
ATOM   1172 N NH2 . ARG A 1 147 ? -76.095  45.515 20.655  1.00 48.60  ? 997  ARG A NH2 1 
ATOM   1173 N N   . GLY A 1 148 ? -71.753  51.409 24.264  1.00 39.80  ? 998  GLY A N   1 
ATOM   1174 C CA  . GLY A 1 148 ? -70.413  51.255 24.792  1.00 40.71  ? 998  GLY A CA  1 
ATOM   1175 C C   . GLY A 1 148 ? -69.359  50.825 23.796  1.00 44.05  ? 998  GLY A C   1 
ATOM   1176 O O   . GLY A 1 148 ? -68.203  50.630 24.194  1.00 40.48  ? 998  GLY A O   1 
ATOM   1177 N N   . TYR A 1 149 ? -69.712  50.682 22.519  1.00 34.80  ? 999  TYR A N   1 
ATOM   1178 C CA  . TYR A 1 149 ? -68.764  50.303 21.475  1.00 35.92  ? 999  TYR A CA  1 
ATOM   1179 C C   . TYR A 1 149 ? -68.397  51.600 20.765  1.00 36.37  ? 999  TYR A C   1 
ATOM   1180 O O   . TYR A 1 149 ? -69.158  52.098 19.932  1.00 36.62  ? 999  TYR A O   1 
ATOM   1181 C CB  . TYR A 1 149 ? -69.377  49.296 20.504  1.00 34.09  ? 999  TYR A CB  1 
ATOM   1182 C CG  . TYR A 1 149 ? -69.948  48.034 21.120  1.00 36.47  ? 999  TYR A CG  1 
ATOM   1183 C CD1 . TYR A 1 149 ? -71.241  47.999 21.635  1.00 37.94  ? 999  TYR A CD1 1 
ATOM   1184 C CD2 . TYR A 1 149 ? -69.201  46.866 21.153  1.00 34.83  ? 999  TYR A CD2 1 
ATOM   1185 C CE1 . TYR A 1 149 ? -71.759  46.836 22.184  1.00 39.53  ? 999  TYR A CE1 1 
ATOM   1186 C CE2 . TYR A 1 149 ? -69.707  45.706 21.696  1.00 35.51  ? 999  TYR A CE2 1 
ATOM   1187 C CZ  . TYR A 1 149 ? -70.984  45.693 22.210  1.00 43.32  ? 999  TYR A CZ  1 
ATOM   1188 O OH  . TYR A 1 149 ? -71.482  44.529 22.751  1.00 41.68  ? 999  TYR A OH  1 
ATOM   1189 N N   . ASP A 1 150 ? -67.218  52.137 21.075  1.00 33.26  ? 1000 ASP A N   1 
ATOM   1190 C CA  . ASP A 1 150 ? -66.769  53.433 20.588  1.00 36.46  ? 1000 ASP A CA  1 
ATOM   1191 C C   . ASP A 1 150 ? -65.707  53.196 19.515  1.00 40.98  ? 1000 ASP A C   1 
ATOM   1192 O O   . ASP A 1 150 ? -64.504  53.091 19.808  1.00 43.62  ? 1000 ASP A O   1 
ATOM   1193 C CB  . ASP A 1 150 ? -66.225  54.242 21.760  1.00 40.82  ? 1000 ASP A CB  1 
ATOM   1194 C CG  . ASP A 1 150 ? -66.145  55.710 21.464  1.00 47.88  ? 1000 ASP A CG  1 
ATOM   1195 O OD1 . ASP A 1 150 ? -66.610  56.116 20.381  1.00 53.08  ? 1000 ASP A OD1 1 
ATOM   1196 O OD2 . ASP A 1 150 ? -65.610  56.456 22.309  1.00 46.19  ? 1000 ASP A OD2 1 
ATOM   1197 N N   . TYR A 1 151 ? -66.139  53.248 18.263  1.00 36.65  ? 1001 TYR A N   1 
ATOM   1198 C CA  . TYR A 1 151 ? -65.258  52.984 17.141  1.00 34.14  ? 1001 TYR A CA  1 
ATOM   1199 C C   . TYR A 1 151 ? -64.878  54.308 16.510  1.00 38.35  ? 1001 TYR A C   1 
ATOM   1200 O O   . TYR A 1 151 ? -65.747  55.073 16.077  1.00 40.63  ? 1001 TYR A O   1 
ATOM   1201 C CB  . TYR A 1 151 ? -65.926  52.063 16.118  1.00 32.20  ? 1001 TYR A CB  1 
ATOM   1202 C CG  . TYR A 1 151 ? -66.272  50.704 16.675  1.00 30.99  ? 1001 TYR A CG  1 
ATOM   1203 C CD1 . TYR A 1 151 ? -65.269  49.834 17.079  1.00 30.13  ? 1001 TYR A CD1 1 
ATOM   1204 C CD2 . TYR A 1 151 ? -67.591  50.296 16.818  1.00 30.79  ? 1001 TYR A CD2 1 
ATOM   1205 C CE1 . TYR A 1 151 ? -65.566  48.592 17.597  1.00 30.10  ? 1001 TYR A CE1 1 
ATOM   1206 C CE2 . TYR A 1 151 ? -67.899  49.052 17.338  1.00 28.07  ? 1001 TYR A CE2 1 
ATOM   1207 C CZ  . TYR A 1 151 ? -66.881  48.205 17.726  1.00 27.49  ? 1001 TYR A CZ  1 
ATOM   1208 O OH  . TYR A 1 151 ? -67.179  46.967 18.245  1.00 29.81  ? 1001 TYR A OH  1 
ATOM   1209 N N   . GLY A 1 152 ? -63.577  54.564 16.457  1.00 33.79  ? 1002 GLY A N   1 
ATOM   1210 C CA  . GLY A 1 152 ? -63.069  55.686 15.722  1.00 34.21  ? 1002 GLY A CA  1 
ATOM   1211 C C   . GLY A 1 152 ? -63.013  55.376 14.248  1.00 35.43  ? 1002 GLY A C   1 
ATOM   1212 O O   . GLY A 1 152 ? -63.369  54.281 13.794  1.00 35.31  ? 1002 GLY A O   1 
ATOM   1213 N N   . PRO A 1 153 ? -62.569  56.364 13.472  1.00 37.16  ? 1003 PRO A N   1 
ATOM   1214 C CA  . PRO A 1 153 ? -62.680  56.259 12.005  1.00 37.40  ? 1003 PRO A CA  1 
ATOM   1215 C C   . PRO A 1 153 ? -62.109  54.983 11.399  1.00 35.85  ? 1003 PRO A C   1 
ATOM   1216 O O   . PRO A 1 153 ? -62.700  54.447 10.453  1.00 33.65  ? 1003 PRO A O   1 
ATOM   1217 C CB  . PRO A 1 153 ? -61.920  57.497 11.516  1.00 42.59  ? 1003 PRO A CB  1 
ATOM   1218 C CG  . PRO A 1 153 ? -62.002  58.479 12.637  1.00 41.21  ? 1003 PRO A CG  1 
ATOM   1219 C CD  . PRO A 1 153 ? -62.288  57.740 13.917  1.00 39.88  ? 1003 PRO A CD  1 
ATOM   1220 N N   . HIS A 1 154 ? -60.975  54.487 11.900  1.00 37.51  ? 1004 HIS A N   1 
ATOM   1221 C CA  . HIS A 1 154 ? -60.352  53.312 11.298  1.00 34.33  ? 1004 HIS A CA  1 
ATOM   1222 C C   . HIS A 1 154 ? -61.181  52.048 11.484  1.00 33.10  ? 1004 HIS A C   1 
ATOM   1223 O O   . HIS A 1 154 ? -60.975  51.074 10.753  1.00 36.00  ? 1004 HIS A O   1 
ATOM   1224 C CB  . HIS A 1 154 ? -58.953  53.097 11.877  1.00 36.63  ? 1004 HIS A CB  1 
ATOM   1225 C CG  . HIS A 1 154 ? -57.924  54.042 11.338  1.00 37.21  ? 1004 HIS A CG  1 
ATOM   1226 N ND1 . HIS A 1 154 ? -57.405  53.935 10.065  1.00 43.62  ? 1004 HIS A ND1 1 
ATOM   1227 C CD2 . HIS A 1 154 ? -57.316  55.112 11.903  1.00 38.55  ? 1004 HIS A CD2 1 
ATOM   1228 C CE1 . HIS A 1 154 ? -56.522  54.899 9.870   1.00 41.01  ? 1004 HIS A CE1 1 
ATOM   1229 N NE2 . HIS A 1 154 ? -56.450  55.627 10.970  1.00 40.17  ? 1004 HIS A NE2 1 
ATOM   1230 N N   . PHE A 1 155 ? -62.105  52.032 12.442  1.00 30.53  ? 1005 PHE A N   1 
ATOM   1231 C CA  . PHE A 1 155 ? -62.961  50.875 12.654  1.00 30.61  ? 1005 PHE A CA  1 
ATOM   1232 C C   . PHE A 1 155 ? -64.407  51.140 12.257  1.00 30.84  ? 1005 PHE A C   1 
ATOM   1233 O O   . PHE A 1 155 ? -65.280  50.308 12.526  1.00 31.75  ? 1005 PHE A O   1 
ATOM   1234 C CB  . PHE A 1 155 ? -62.866  50.407 14.108  1.00 28.86  ? 1005 PHE A CB  1 
ATOM   1235 C CG  . PHE A 1 155 ? -61.675  49.529 14.369  1.00 30.29  ? 1005 PHE A CG  1 
ATOM   1236 C CD1 . PHE A 1 155 ? -60.424  50.083 14.592  1.00 29.03  ? 1005 PHE A CD1 1 
ATOM   1237 C CD2 . PHE A 1 155 ? -61.794  48.149 14.334  1.00 29.50  ? 1005 PHE A CD2 1 
ATOM   1238 C CE1 . PHE A 1 155 ? -59.321  49.277 14.811  1.00 28.86  ? 1005 PHE A CE1 1 
ATOM   1239 C CE2 . PHE A 1 155 ? -60.694  47.337 14.550  1.00 30.89  ? 1005 PHE A CE2 1 
ATOM   1240 C CZ  . PHE A 1 155 ? -59.456  47.902 14.789  1.00 27.37  ? 1005 PHE A CZ  1 
ATOM   1241 N N   . GLN A 1 156 ? -64.677  52.267 11.599  1.00 30.24  ? 1006 GLN A N   1 
ATOM   1242 C CA  . GLN A 1 156 ? -66.018  52.575 11.099  1.00 31.15  ? 1006 GLN A CA  1 
ATOM   1243 C C   . GLN A 1 156 ? -66.153  52.104 9.650   1.00 35.55  ? 1006 GLN A C   1 
ATOM   1244 O O   . GLN A 1 156 ? -66.160  52.886 8.698   1.00 38.67  ? 1006 GLN A O   1 
ATOM   1245 C CB  . GLN A 1 156 ? -66.313  54.060 11.241  1.00 34.31  ? 1006 GLN A CB  1 
ATOM   1246 C CG  . GLN A 1 156 ? -66.611  54.482 12.664  1.00 32.16  ? 1006 GLN A CG  1 
ATOM   1247 C CD  . GLN A 1 156 ? -66.967  55.946 12.762  1.00 47.38  ? 1006 GLN A CD  1 
ATOM   1248 O OE1 . GLN A 1 156 ? -67.362  56.565 11.774  1.00 47.12  ? 1006 GLN A OE1 1 
ATOM   1249 N NE2 . GLN A 1 156 ? -66.822  56.514 13.953  1.00 43.24  ? 1006 GLN A NE2 1 
ATOM   1250 N N   . GLY A 1 157 ? -66.232  50.789 9.464   1.00 30.25  ? 1007 GLY A N   1 
ATOM   1251 C CA  . GLY A 1 157 ? -66.320  50.208 8.107   1.00 31.23  ? 1007 GLY A CA  1 
ATOM   1252 C C   . GLY A 1 157 ? -67.732  49.872 7.660   1.00 36.28  ? 1007 GLY A C   1 
ATOM   1253 O O   . GLY A 1 157 ? -67.906  49.576 6.490   1.00 33.15  ? 1007 GLY A O   1 
ATOM   1254 N N   . ILE A 1 158 ? -68.693  49.903 8.575   1.00 33.86  ? 1008 ILE A N   1 
ATOM   1255 C CA  . ILE A 1 158 ? -70.110  49.704 8.184   1.00 30.64  ? 1008 ILE A CA  1 
ATOM   1256 C C   . ILE A 1 158 ? -70.580  50.998 7.527   1.00 34.54  ? 1008 ILE A C   1 
ATOM   1257 O O   . ILE A 1 158 ? -70.662  52.001 8.211   1.00 35.27  ? 1008 ILE A O   1 
ATOM   1258 C CB  . ILE A 1 158 ? -70.998  49.318 9.376   1.00 32.59  ? 1008 ILE A CB  1 
ATOM   1259 C CG1 . ILE A 1 158 ? -70.457  48.092 10.114  1.00 30.25  ? 1008 ILE A CG1 1 
ATOM   1260 C CG2 . ILE A 1 158 ? -72.435  49.120 8.924   1.00 28.98  ? 1008 ILE A CG2 1 
ATOM   1261 C CD1 . ILE A 1 158 ? -71.165  47.803 11.409  1.00 31.52  ? 1008 ILE A CD1 1 
ATOM   1262 N N   . LEU A 1 159 ? -70.839  50.948 6.233   1.00 35.92  ? 1009 LEU A N   1 
ATOM   1263 C CA  . LEU A 1 159 ? -71.291  52.137 5.473   1.00 36.84  ? 1009 LEU A CA  1 
ATOM   1264 C C   . LEU A 1 159 ? -72.815  52.209 5.554   1.00 34.79  ? 1009 LEU A C   1 
ATOM   1265 O O   . LEU A 1 159 ? -73.343  53.311 5.578   1.00 38.05  ? 1009 LEU A O   1 
ATOM   1266 C CB  . LEU A 1 159 ? -70.831  51.972 4.025   1.00 39.47  ? 1009 LEU A CB  1 
ATOM   1267 C CG  . LEU A 1 159 ? -69.328  51.828 3.842   1.00 41.06  ? 1009 LEU A CG  1 
ATOM   1268 C CD1 . LEU A 1 159 ? -68.981  51.737 2.368   1.00 47.83  ? 1009 LEU A CD1 1 
ATOM   1269 C CD2 . LEU A 1 159 ? -68.619  53.003 4.487   1.00 46.72  ? 1009 LEU A CD2 1 
ATOM   1270 N N   . GLU A 1 160 ? -73.448  51.053 5.599   1.00 34.52  ? 1010 GLU A N   1 
ATOM   1271 C CA  . GLU A 1 160 ? -74.917  50.975 5.680   1.00 40.77  ? 1010 GLU A CA  1 
ATOM   1272 C C   . GLU A 1 160 ? -75.296  49.657 6.333   1.00 39.42  ? 1010 GLU A C   1 
ATOM   1273 O O   . GLU A 1 160 ? -74.556  48.696 6.200   1.00 36.08  ? 1010 GLU A O   1 
ATOM   1274 C CB  . GLU A 1 160 ? -75.548  50.980 4.292   1.00 44.07  ? 1010 GLU A CB  1 
ATOM   1275 C CG  . GLU A 1 160 ? -75.725  52.338 3.668   1.00 58.41  ? 1010 GLU A CG  1 
ATOM   1276 C CD  . GLU A 1 160 ? -76.884  52.311 2.689   1.00 60.25  ? 1010 GLU A CD  1 
ATOM   1277 O OE1 . GLU A 1 160 ? -76.916  51.401 1.851   1.00 60.17  ? 1010 GLU A OE1 1 
ATOM   1278 O OE2 . GLU A 1 160 ? -77.750  53.190 2.780   1.00 69.51  ? 1010 GLU A OE2 1 
ATOM   1279 N N   . ALA A 1 161 ? -76.436  49.650 6.992   1.00 33.98  ? 1011 ALA A N   1 
ATOM   1280 C CA  . ALA A 1 161 ? -76.932  48.410 7.592   1.00 34.63  ? 1011 ALA A CA  1 
ATOM   1281 C C   . ALA A 1 161 ? -78.457  48.421 7.670   1.00 43.75  ? 1011 ALA A C   1 
ATOM   1282 O O   . ALA A 1 161 ? -79.035  49.484 7.828   1.00 49.29  ? 1011 ALA A O   1 
ATOM   1283 C CB  . ALA A 1 161 ? -76.346  48.208 8.953   1.00 34.31  ? 1011 ALA A CB  1 
ATOM   1284 N N   . SER A 1 162 ? -79.050  47.254 7.535   1.00 40.30  ? 1012 SER A N   1 
ATOM   1285 C CA  . SER A 1 162 ? -80.492  47.139 7.679   1.00 50.43  ? 1012 SER A CA  1 
ATOM   1286 C C   . SER A 1 162 ? -80.923  47.450 9.111   1.00 54.36  ? 1012 SER A C   1 
ATOM   1287 O O   . SER A 1 162 ? -80.137  47.399 10.063  1.00 51.40  ? 1012 SER A O   1 
ATOM   1288 C CB  . SER A 1 162 ? -80.983  45.752 7.264   1.00 48.17  ? 1012 SER A CB  1 
ATOM   1289 O OG  . SER A 1 162 ? -80.560  44.761 8.178   1.00 47.34  ? 1012 SER A OG  1 
ATOM   1290 N N   . LEU A 1 163 ? -82.212  47.754 9.244   1.00 62.49  ? 1013 LEU A N   1 
ATOM   1291 C CA  . LEU A 1 163 ? -82.800  48.097 10.536  1.00 64.51  ? 1013 LEU A CA  1 
ATOM   1292 C C   . LEU A 1 163 ? -82.632  46.968 11.548  1.00 56.02  ? 1013 LEU A C   1 
ATOM   1293 O O   . LEU A 1 163 ? -82.405  47.222 12.737  1.00 64.42  ? 1013 LEU A O   1 
ATOM   1294 C CB  . LEU A 1 163 ? -84.269  48.479 10.347  1.00 71.43  ? 1013 LEU A CB  1 
ATOM   1295 C CG  . LEU A 1 163 ? -85.348  47.512 9.840   1.00 75.44  ? 1013 LEU A CG  1 
ATOM   1296 C CD1 . LEU A 1 163 ? -86.610  48.305 9.508   1.00 76.00  ? 1013 LEU A CD1 1 
ATOM   1297 C CD2 . LEU A 1 163 ? -84.948  46.587 8.688   1.00 64.83  ? 1013 LEU A CD2 1 
ATOM   1298 N N   . GLU A 1 164 ? -82.778  45.722 11.109  1.00 57.48  ? 1014 GLU A N   1 
ATOM   1299 C CA  . GLU A 1 164 ? -82.620  44.569 11.983  1.00 54.81  ? 1014 GLU A CA  1 
ATOM   1300 C C   . GLU A 1 164 ? -81.167  44.129 12.125  1.00 51.11  ? 1014 GLU A C   1 
ATOM   1301 O O   . GLU A 1 164 ? -80.889  43.205 12.897  1.00 50.63  ? 1014 GLU A O   1 
ATOM   1302 C CB  . GLU A 1 164 ? -83.432  43.385 11.439  1.00 58.66  ? 1014 GLU A CB  1 
ATOM   1303 C CG  . GLU A 1 164 ? -84.920  43.288 11.826  1.00 65.93  ? 1014 GLU A CG  1 
ATOM   1304 C CD  . GLU A 1 164 ? -85.250  43.500 13.304  1.00 69.94  ? 1014 GLU A CD  1 
ATOM   1305 O OE1 . GLU A 1 164 ? -84.344  43.603 14.157  1.00 68.22  ? 1014 GLU A OE1 1 
ATOM   1306 O OE2 . GLU A 1 164 ? -86.459  43.555 13.614  1.00 67.86  ? 1014 GLU A OE2 1 
ATOM   1307 N N   . GLY A 1 165 ? -80.236  44.779 11.429  1.00 48.56  ? 1015 GLY A N   1 
ATOM   1308 C CA  . GLY A 1 165 ? -78.835  44.463 11.612  1.00 44.66  ? 1015 GLY A CA  1 
ATOM   1309 C C   . GLY A 1 165 ? -78.444  43.146 10.985  1.00 46.59  ? 1015 GLY A C   1 
ATOM   1310 O O   . GLY A 1 165 ? -77.454  42.537 11.397  1.00 48.79  ? 1015 GLY A O   1 
ATOM   1311 N N   . ASP A 1 166 ? -79.208  42.685 9.996   1.00 37.87  ? 1016 ASP A N   1 
ATOM   1312 C CA  . ASP A 1 166 ? -78.985  41.399 9.352   1.00 38.56  ? 1016 ASP A CA  1 
ATOM   1313 C C   . ASP A 1 166 ? -78.343  41.512 7.976   1.00 33.46  ? 1016 ASP A C   1 
ATOM   1314 O O   . ASP A 1 166 ? -78.003  40.485 7.381   1.00 38.79  ? 1016 ASP A O   1 
ATOM   1315 C CB  . ASP A 1 166 ? -80.311  40.640 9.249   1.00 46.68  ? 1016 ASP A CB  1 
ATOM   1316 C CG  . ASP A 1 166 ? -81.289  41.306 8.303   1.00 53.16  ? 1016 ASP A CG  1 
ATOM   1317 O OD1 . ASP A 1 166 ? -81.499  42.530 8.438   1.00 55.31  ? 1016 ASP A OD1 1 
ATOM   1318 O OD2 . ASP A 1 166 ? -81.861  40.607 7.441   1.00 61.08  ? 1016 ASP A OD2 1 
ATOM   1319 N N   . SER A 1 167 ? -78.148  42.723 7.466   1.00 35.21  ? 1017 SER A N   1 
ATOM   1320 C CA  . SER A 1 167 ? -77.471  42.896 6.193   1.00 37.89  ? 1017 SER A CA  1 
ATOM   1321 C C   . SER A 1 167 ? -76.828  44.269 6.174   1.00 35.31  ? 1017 SER A C   1 
ATOM   1322 O O   . SER A 1 167 ? -77.230  45.176 6.908   1.00 36.61  ? 1017 SER A O   1 
ATOM   1323 C CB  . SER A 1 167 ? -78.440  42.748 5.010   1.00 42.85  ? 1017 SER A CB  1 
ATOM   1324 O OG  . SER A 1 167 ? -79.126  43.963 4.753   1.00 47.79  ? 1017 SER A OG  1 
ATOM   1325 N N   . GLY A 1 168 ? -75.840  44.423 5.304   1.00 31.46  ? 1018 GLY A N   1 
ATOM   1326 C CA  . GLY A 1 168 ? -75.197  45.716 5.188   1.00 32.35  ? 1018 GLY A CA  1 
ATOM   1327 C C   . GLY A 1 168 ? -74.078  45.690 4.175   1.00 28.15  ? 1018 GLY A C   1 
ATOM   1328 O O   . GLY A 1 168 ? -73.884  44.709 3.459   1.00 31.58  ? 1018 GLY A O   1 
ATOM   1329 N N   . ARG A 1 169 ? -73.277  46.749 4.202   1.00 30.41  ? 1019 ARG A N   1 
ATOM   1330 C CA  . ARG A 1 169 ? -72.192  46.939 3.250   1.00 32.09  ? 1019 ARG A CA  1 
ATOM   1331 C C   . ARG A 1 169 ? -70.987  47.425 4.036   1.00 33.75  ? 1019 ARG A C   1 
ATOM   1332 O O   . ARG A 1 169 ? -71.096  48.368 4.828   1.00 31.61  ? 1019 ARG A O   1 
ATOM   1333 C CB  . ARG A 1 169 ? -72.573  47.927 2.130   1.00 36.36  ? 1019 ARG A CB  1 
ATOM   1334 C CG  . ARG A 1 169 ? -71.417  48.707 1.516   1.00 43.49  ? 1019 ARG A CG  1 
ATOM   1335 C CD  . ARG A 1 169 ? -71.900  49.597 0.367   1.00 48.52  ? 1019 ARG A CD  1 
ATOM   1336 N NE  . ARG A 1 169 ? -72.994  48.987 -0.383  1.00 50.27  ? 1019 ARG A NE  1 
ATOM   1337 C CZ  . ARG A 1 169 ? -73.714  49.609 -1.307  1.00 52.96  ? 1019 ARG A CZ  1 
ATOM   1338 N NH1 . ARG A 1 169 ? -73.512  50.884 -1.600  1.00 55.57  ? 1019 ARG A NH1 1 
ATOM   1339 N NH2 . ARG A 1 169 ? -74.669  48.939 -1.946  1.00 59.83  ? 1019 ARG A NH2 1 
ATOM   1340 N N   . LEU A 1 170 ? -69.869  46.719 3.891   1.00 31.05  ? 1020 LEU A N   1 
ATOM   1341 C CA  . LEU A 1 170 ? -68.667  46.949 4.676   1.00 29.82  ? 1020 LEU A CA  1 
ATOM   1342 C C   . LEU A 1 170 ? -67.567  47.491 3.773   1.00 34.56  ? 1020 LEU A C   1 
ATOM   1343 O O   . LEU A 1 170 ? -67.318  46.939 2.693   1.00 33.21  ? 1020 LEU A O   1 
ATOM   1344 C CB  . LEU A 1 170 ? -68.193  45.648 5.337   1.00 29.36  ? 1020 LEU A CB  1 
ATOM   1345 C CG  . LEU A 1 170 ? -69.157  44.874 6.237   1.00 28.16  ? 1020 LEU A CG  1 
ATOM   1346 C CD1 . LEU A 1 170 ? -68.494  43.623 6.800   1.00 29.43  ? 1020 LEU A CD1 1 
ATOM   1347 C CD2 . LEU A 1 170 ? -69.634  45.772 7.359   1.00 28.83  ? 1020 LEU A CD2 1 
ATOM   1348 N N   . LEU A 1 171 ? -66.874  48.530 4.246   1.00 29.51  ? 1021 LEU A N   1 
ATOM   1349 C CA  . LEU A 1 171 ? -65.711  49.040 3.532   1.00 31.97  ? 1021 LEU A CA  1 
ATOM   1350 C C   . LEU A 1 171 ? -64.565  48.051 3.604   1.00 34.49  ? 1021 LEU A C   1 
ATOM   1351 O O   . LEU A 1 171 ? -64.383  47.346 4.599   1.00 30.45  ? 1021 LEU A O   1 
ATOM   1352 C CB  . LEU A 1 171 ? -65.195  50.351 4.125   1.00 32.59  ? 1021 LEU A CB  1 
ATOM   1353 C CG  . LEU A 1 171 ? -65.706  51.730 3.769   1.00 52.52  ? 1021 LEU A CG  1 
ATOM   1354 C CD1 . LEU A 1 171 ? -65.066  52.767 4.682   1.00 52.52  ? 1021 LEU A CD1 1 
ATOM   1355 C CD2 . LEU A 1 171 ? -65.386  52.020 2.314   1.00 45.94  ? 1021 LEU A CD2 1 
ATOM   1356 N N   . TRP A 1 172 ? -63.784  48.012 2.529   1.00 30.94  ? 1022 TRP A N   1 
ATOM   1357 C CA  . TRP A 1 172 ? -62.524  47.285 2.486   1.00 31.30  ? 1022 TRP A CA  1 
ATOM   1358 C C   . TRP A 1 172 ? -61.391  48.259 2.201   1.00 33.41  ? 1022 TRP A C   1 
ATOM   1359 O O   . TRP A 1 172 ? -61.430  48.984 1.200   1.00 31.61  ? 1022 TRP A O   1 
ATOM   1360 C CB  . TRP A 1 172 ? -62.573  46.194 1.419   1.00 31.40  ? 1022 TRP A CB  1 
ATOM   1361 C CG  . TRP A 1 172 ? -61.265  45.510 1.187   1.00 30.63  ? 1022 TRP A CG  1 
ATOM   1362 C CD1 . TRP A 1 172 ? -60.465  45.620 0.088   1.00 34.78  ? 1022 TRP A CD1 1 
ATOM   1363 C CD2 . TRP A 1 172 ? -60.619  44.577 2.063   1.00 31.70  ? 1022 TRP A CD2 1 
ATOM   1364 N NE1 . TRP A 1 172 ? -59.353  44.825 0.232   1.00 34.40  ? 1022 TRP A NE1 1 
ATOM   1365 C CE2 . TRP A 1 172 ? -59.425  44.173 1.435   1.00 31.34  ? 1022 TRP A CE2 1 
ATOM   1366 C CE3 . TRP A 1 172 ? -60.932  44.050 3.321   1.00 30.48  ? 1022 TRP A CE3 1 
ATOM   1367 C CZ2 . TRP A 1 172 ? -58.543  43.265 2.020   1.00 30.01  ? 1022 TRP A CZ2 1 
ATOM   1368 C CZ3 . TRP A 1 172 ? -60.054  43.150 3.901   1.00 29.58  ? 1022 TRP A CZ3 1 
ATOM   1369 C CH2 . TRP A 1 172 ? -58.873  42.768 3.251   1.00 32.01  ? 1022 TRP A CH2 1 
ATOM   1370 N N   . LYS A 1 173 ? -60.404  48.297 3.091   1.00 30.99  ? 1023 LYS A N   1 
ATOM   1371 C CA  . LYS A 1 173 ? -59.231  49.154 2.956   1.00 36.88  ? 1023 LYS A CA  1 
ATOM   1372 C C   . LYS A 1 173 ? -57.951  48.343 3.116   1.00 35.00  ? 1023 LYS A C   1 
ATOM   1373 O O   . LYS A 1 173 ? -56.977  48.799 3.722   1.00 38.20  ? 1023 LYS A O   1 
ATOM   1374 C CB  . LYS A 1 173 ? -59.275  50.319 3.939   1.00 45.64  ? 1023 LYS A CB  1 
ATOM   1375 C CG  . LYS A 1 173 ? -60.583  51.085 3.906   1.00 50.05  ? 1023 LYS A CG  1 
ATOM   1376 C CD  . LYS A 1 173 ? -60.557  52.265 4.853   1.00 56.88  ? 1023 LYS A CD  1 
ATOM   1377 C CE  . LYS A 1 173 ? -60.281  53.559 4.107   1.00 61.87  ? 1023 LYS A CE  1 
ATOM   1378 N NZ  . LYS A 1 173 ? -58.829  53.821 3.959   1.00 66.10  ? 1023 LYS A NZ  1 
ATOM   1379 N N   . ASP A 1 174 ? -57.951  47.118 2.587   1.00 32.29  ? 1024 ASP A N   1 
ATOM   1380 C CA  . ASP A 1 174 ? -56.822  46.185 2.689   1.00 31.54  ? 1024 ASP A CA  1 
ATOM   1381 C C   . ASP A 1 174 ? -56.377  45.967 4.133   1.00 36.97  ? 1024 ASP A C   1 
ATOM   1382 O O   . ASP A 1 174 ? -55.191  45.799 4.421   1.00 36.89  ? 1024 ASP A O   1 
ATOM   1383 C CB  . ASP A 1 174 ? -55.642  46.668 1.845   1.00 37.81  ? 1024 ASP A CB  1 
ATOM   1384 C CG  . ASP A 1 174 ? -55.866  46.474 0.363   1.00 44.52  ? 1024 ASP A CG  1 
ATOM   1385 O OD1 . ASP A 1 174 ? -55.970  45.310 -0.076  1.00 49.55  ? 1024 ASP A OD1 1 
ATOM   1386 O OD2 . ASP A 1 174 ? -55.934  47.487 -0.363  1.00 53.70  ? 1024 ASP A OD2 1 
ATOM   1387 N N   . ASN A 1 175 ? -57.343  45.884 5.041   1.00 31.46  ? 1025 ASN A N   1 
ATOM   1388 C CA  . ASN A 1 175 ? -57.061  45.690 6.459   1.00 30.35  ? 1025 ASN A CA  1 
ATOM   1389 C C   . ASN A 1 175 ? -57.964  44.563 6.931   1.00 33.58  ? 1025 ASN A C   1 
ATOM   1390 O O   . ASN A 1 175 ? -59.172  44.760 7.094   1.00 28.21  ? 1025 ASN A O   1 
ATOM   1391 C CB  . ASN A 1 175 ? -57.315  46.971 7.257   1.00 30.95  ? 1025 ASN A CB  1 
ATOM   1392 C CG  . ASN A 1 175 ? -56.870  46.859 8.706   1.00 33.55  ? 1025 ASN A CG  1 
ATOM   1393 O OD1 . ASN A 1 175 ? -57.055  45.828 9.349   1.00 27.42  ? 1025 ASN A OD1 1 
ATOM   1394 N ND2 . ASN A 1 175 ? -56.314  47.942 9.237   1.00 36.79  ? 1025 ASN A ND2 1 
ATOM   1395 N N   . TRP A 1 176 ? -57.383  43.380 7.138   1.00 27.39  ? 1026 TRP A N   1 
ATOM   1396 C CA  . TRP A 1 176 ? -58.193  42.241 7.551   1.00 29.06  ? 1026 TRP A CA  1 
ATOM   1397 C C   . TRP A 1 176 ? -58.723  42.416 8.967   1.00 29.02  ? 1026 TRP A C   1 
ATOM   1398 O O   . TRP A 1 176 ? -59.829  41.951 9.277   1.00 29.02  ? 1026 TRP A O   1 
ATOM   1399 C CB  . TRP A 1 176 ? -57.388  40.947 7.448   1.00 29.16  ? 1026 TRP A CB  1 
ATOM   1400 C CG  . TRP A 1 176 ? -57.139  40.487 6.041   1.00 29.37  ? 1026 TRP A CG  1 
ATOM   1401 C CD1 . TRP A 1 176 ? -55.998  40.668 5.315   1.00 32.70  ? 1026 TRP A CD1 1 
ATOM   1402 C CD2 . TRP A 1 176 ? -58.052  39.784 5.185   1.00 28.99  ? 1026 TRP A CD2 1 
ATOM   1403 N NE1 . TRP A 1 176 ? -56.138  40.113 4.066   1.00 28.82  ? 1026 TRP A NE1 1 
ATOM   1404 C CE2 . TRP A 1 176 ? -57.389  39.566 3.960   1.00 31.67  ? 1026 TRP A CE2 1 
ATOM   1405 C CE3 . TRP A 1 176 ? -59.361  39.316 5.336   1.00 32.74  ? 1026 TRP A CE3 1 
ATOM   1406 C CZ2 . TRP A 1 176 ? -57.991  38.901 2.892   1.00 33.79  ? 1026 TRP A CZ2 1 
ATOM   1407 C CZ3 . TRP A 1 176 ? -59.957  38.655 4.273   1.00 32.74  ? 1026 TRP A CZ3 1 
ATOM   1408 C CH2 . TRP A 1 176 ? -59.271  38.454 3.068   1.00 32.17  ? 1026 TRP A CH2 1 
ATOM   1409 N N   . VAL A 1 177 ? -57.964  43.093 9.831   1.00 26.23  ? 1027 VAL A N   1 
ATOM   1410 C CA  . VAL A 1 177 ? -58.357  43.205 11.231  1.00 26.44  ? 1027 VAL A CA  1 
ATOM   1411 C C   . VAL A 1 177 ? -59.619  44.051 11.360  1.00 26.14  ? 1027 VAL A C   1 
ATOM   1412 O O   . VAL A 1 177 ? -60.604  43.633 11.980  1.00 29.11  ? 1027 VAL A O   1 
ATOM   1413 C CB  . VAL A 1 177 ? -57.198  43.777 12.068  1.00 25.94  ? 1027 VAL A CB  1 
ATOM   1414 C CG1 . VAL A 1 177 ? -57.682  44.174 13.457  1.00 25.80  ? 1027 VAL A CG1 1 
ATOM   1415 C CG2 . VAL A 1 177 ? -56.061  42.774 12.151  1.00 27.65  ? 1027 VAL A CG2 1 
ATOM   1416 N N   . SER A 1 178 ? -59.632  45.231 10.735  1.00 27.67  ? 1028 SER A N   1 
ATOM   1417 C CA  . SER A 1 178 ? -60.802  46.099 10.849  1.00 28.30  ? 1028 SER A CA  1 
ATOM   1418 C C   . SER A 1 178 ? -61.979  45.582 10.022  1.00 28.52  ? 1028 SER A C   1 
ATOM   1419 O O   . SER A 1 178 ? -63.135  45.716 10.441  1.00 27.66  ? 1028 SER A O   1 
ATOM   1420 C CB  . SER A 1 178 ? -60.442  47.532 10.452  1.00 31.02  ? 1028 SER A CB  1 
ATOM   1421 O OG  . SER A 1 178 ? -59.980  47.605 9.118   1.00 31.47  ? 1028 SER A OG  1 
ATOM   1422 N N   . PHE A 1 179 ? -61.721  44.986 8.852   1.00 28.14  ? 1029 PHE A N   1 
ATOM   1423 C CA  . PHE A 1 179 ? -62.817  44.401 8.077   1.00 28.37  ? 1029 PHE A CA  1 
ATOM   1424 C C   . PHE A 1 179 ? -63.530  43.324 8.887   1.00 26.67  ? 1029 PHE A C   1 
ATOM   1425 O O   . PHE A 1 179 ? -64.771  43.302 9.007   1.00 29.15  ? 1029 PHE A O   1 
ATOM   1426 C CB  . PHE A 1 179 ? -62.298  43.812 6.760   1.00 28.11  ? 1029 PHE A CB  1 
ATOM   1427 C CG  . PHE A 1 179 ? -63.379  43.179 5.919   1.00 24.96  ? 1029 PHE A CG  1 
ATOM   1428 C CD1 . PHE A 1 179 ? -64.156  43.961 5.082   1.00 28.55  ? 1029 PHE A CD1 1 
ATOM   1429 C CD2 . PHE A 1 179 ? -63.638  41.817 5.986   1.00 25.59  ? 1029 PHE A CD2 1 
ATOM   1430 C CE1 . PHE A 1 179 ? -65.163  43.401 4.316   1.00 26.11  ? 1029 PHE A CE1 1 
ATOM   1431 C CE2 . PHE A 1 179 ? -64.649  41.248 5.221   1.00 27.72  ? 1029 PHE A CE2 1 
ATOM   1432 C CZ  . PHE A 1 179 ? -65.410  42.043 4.385   1.00 28.07  ? 1029 PHE A CZ  1 
ATOM   1433 N N   . MET A 1 180 ? -62.750  42.406 9.447   1.00 25.45  ? 1030 MET A N   1 
ATOM   1434 C CA  . MET A 1 180 ? -63.337  41.325 10.214  1.00 27.03  ? 1030 MET A CA  1 
ATOM   1435 C C   . MET A 1 180 ? -63.996  41.857 11.488  1.00 25.68  ? 1030 MET A C   1 
ATOM   1436 O O   . MET A 1 180 ? -65.053  41.352 11.916  1.00 27.41  ? 1030 MET A O   1 
ATOM   1437 C CB  . MET A 1 180 ? -62.231  40.306 10.472  1.00 30.85  ? 1030 MET A CB  1 
ATOM   1438 C CG  . MET A 1 180 ? -62.218  39.228 9.389   1.00 30.23  ? 1030 MET A CG  1 
ATOM   1439 S SD  . MET A 1 180 ? -61.209  37.768 9.678   1.00 30.66  ? 1030 MET A SD  1 
ATOM   1440 C CE  . MET A 1 180 ? -59.661  38.514 10.186  1.00 28.98  ? 1030 MET A CE  1 
ATOM   1441 N N   . ASP A 1 181 ? -63.437  42.927 12.067  1.00 24.48  ? 1031 ASP A N   1 
ATOM   1442 C CA  . ASP A 1 181 ? -64.081  43.525 13.227  1.00 26.71  ? 1031 ASP A CA  1 
ATOM   1443 C C   . ASP A 1 181 ? -65.444  44.091 12.865  1.00 27.95  ? 1031 ASP A C   1 
ATOM   1444 O O   . ASP A 1 181 ? -66.383  43.997 13.657  1.00 28.17  ? 1031 ASP A O   1 
ATOM   1445 C CB  . ASP A 1 181 ? -63.209  44.617 13.839  1.00 25.68  ? 1031 ASP A CB  1 
ATOM   1446 C CG  . ASP A 1 181 ? -63.729  45.072 15.190  1.00 30.61  ? 1031 ASP A CG  1 
ATOM   1447 O OD1 . ASP A 1 181 ? -63.625  44.283 16.153  1.00 34.37  ? 1031 ASP A OD1 1 
ATOM   1448 O OD2 . ASP A 1 181 ? -64.263  46.196 15.289  1.00 30.92  ? 1031 ASP A OD2 1 
ATOM   1449 N N   . THR A 1 182 ? -65.577  44.686 11.678  1.00 26.55  ? 1032 THR A N   1 
ATOM   1450 C CA  . THR A 1 182 ? -66.889  45.204 11.300  1.00 25.06  ? 1032 THR A CA  1 
ATOM   1451 C C   . THR A 1 182 ? -67.886  44.084 11.030  1.00 27.50  ? 1032 THR A C   1 
ATOM   1452 O O   . THR A 1 182 ? -69.093  44.287 11.222  1.00 29.25  ? 1032 THR A O   1 
ATOM   1453 C CB  . THR A 1 182 ? -66.778  46.148 10.098  1.00 26.95  ? 1032 THR A CB  1 
ATOM   1454 O OG1 . THR A 1 182 ? -66.220  45.458 8.973   1.00 30.01  ? 1032 THR A OG1 1 
ATOM   1455 C CG2 . THR A 1 182 ? -65.907  47.351 10.452  1.00 27.10  ? 1032 THR A CG2 1 
ATOM   1456 N N   . MET A 1 183 ? -67.418  42.888 10.658  1.00 25.93  ? 1033 MET A N   1 
ATOM   1457 C CA  . MET A 1 183 ? -68.356  41.758 10.661  1.00 27.47  ? 1033 MET A CA  1 
ATOM   1458 C C   . MET A 1 183 ? -68.849  41.434 12.075  1.00 30.71  ? 1033 MET A C   1 
ATOM   1459 O O   . MET A 1 183 ? -70.048  41.178 12.285  1.00 28.49  ? 1033 MET A O   1 
ATOM   1460 C CB  . MET A 1 183 ? -67.733  40.517 10.022  1.00 25.35  ? 1033 MET A CB  1 
ATOM   1461 C CG  . MET A 1 183 ? -67.143  40.763 8.652   1.00 25.47  ? 1033 MET A CG  1 
ATOM   1462 S SD  . MET A 1 183 ? -66.323  39.321 7.948   1.00 27.17  ? 1033 MET A SD  1 
ATOM   1463 C CE  . MET A 1 183 ? -67.637  38.103 7.974   1.00 27.06  ? 1033 MET A CE  1 
ATOM   1464 N N   . LEU A 1 184 ? -67.947  41.449 13.062  1.00 26.09  ? 1034 LEU A N   1 
ATOM   1465 C CA  . LEU A 1 184 ? -68.414  41.240 14.439  1.00 25.71  ? 1034 LEU A CA  1 
ATOM   1466 C C   . LEU A 1 184 ? -69.324  42.379 14.909  1.00 28.37  ? 1034 LEU A C   1 
ATOM   1467 O O   . LEU A 1 184 ? -70.286  42.151 15.658  1.00 31.94  ? 1034 LEU A O   1 
ATOM   1468 C CB  . LEU A 1 184 ? -67.233  41.060 15.393  1.00 27.55  ? 1034 LEU A CB  1 
ATOM   1469 C CG  . LEU A 1 184 ? -66.287  39.884 15.133  1.00 27.61  ? 1034 LEU A CG  1 
ATOM   1470 C CD1 . LEU A 1 184 ? -65.334  39.711 16.306  1.00 32.67  ? 1034 LEU A CD1 1 
ATOM   1471 C CD2 . LEU A 1 184 ? -67.048  38.590 14.874  1.00 31.08  ? 1034 LEU A CD2 1 
ATOM   1472 N N   . GLN A 1 185 ? -69.040  43.609 14.475  1.00 25.48  ? 1035 GLN A N   1 
ATOM   1473 C CA  . GLN A 1 185 ? -69.909  44.734 14.808  1.00 27.56  ? 1035 GLN A CA  1 
ATOM   1474 C C   . GLN A 1 185 ? -71.306  44.506 14.260  1.00 33.68  ? 1035 GLN A C   1 
ATOM   1475 O O   . GLN A 1 185 ? -72.298  44.822 14.921  1.00 34.78  ? 1035 GLN A O   1 
ATOM   1476 C CB  . GLN A 1 185 ? -69.354  46.046 14.251  1.00 27.08  ? 1035 GLN A CB  1 
ATOM   1477 C CG  . GLN A 1 185 ? -68.026  46.514 14.805  1.00 26.80  ? 1035 GLN A CG  1 
ATOM   1478 C CD  . GLN A 1 185 ? -67.496  47.705 14.031  1.00 31.05  ? 1035 GLN A CD  1 
ATOM   1479 O OE1 . GLN A 1 185 ? -68.251  48.394 13.343  1.00 29.78  ? 1035 GLN A OE1 1 
ATOM   1480 N NE2 . GLN A 1 185 ? -66.196  47.949 14.130  1.00 29.43  ? 1035 GLN A NE2 1 
ATOM   1481 N N   . MET A 1 186 ? -71.400  43.991 13.031  1.00 30.40  ? 1036 MET A N   1 
ATOM   1482 C CA  . MET A 1 186 ? -72.711  43.682 12.469  1.00 30.64  ? 1036 MET A CA  1 
ATOM   1483 C C   . MET A 1 186 ? -73.428  42.613 13.280  1.00 38.27  ? 1036 MET A C   1 
ATOM   1484 O O   . MET A 1 186 ? -74.644  42.701 13.492  1.00 38.23  ? 1036 MET A O   1 
ATOM   1485 C CB  . MET A 1 186 ? -72.582  43.251 11.013  1.00 33.76  ? 1036 MET A CB  1 
ATOM   1486 C CG  . MET A 1 186 ? -72.187  44.387 10.111  1.00 34.21  ? 1036 MET A CG  1 
ATOM   1487 S SD  . MET A 1 186 ? -73.632  45.396 9.728   1.00 38.11  ? 1036 MET A SD  1 
ATOM   1488 C CE  . MET A 1 186 ? -74.929  44.158 9.691   1.00 37.12  ? 1036 MET A CE  1 
ATOM   1489 N N   . SER A 1 187 ? -72.702  41.579 13.715  1.00 37.81  ? 1037 SER A N   1 
ATOM   1490 C CA  A SER A 1 187 ? -73.316  40.567 14.573  0.58 41.04  ? 1037 SER A CA  1 
ATOM   1491 C CA  B SER A 1 187 ? -73.329  40.570 14.564  0.42 41.02  ? 1037 SER A CA  1 
ATOM   1492 C C   . SER A 1 187 ? -73.872  41.189 15.849  1.00 41.21  ? 1037 SER A C   1 
ATOM   1493 O O   . SER A 1 187 ? -74.944  40.798 16.328  1.00 50.25  ? 1037 SER A O   1 
ATOM   1494 C CB  A SER A 1 187 ? -72.299  39.478 14.910  0.58 42.91  ? 1037 SER A CB  1 
ATOM   1495 C CB  B SER A 1 187 ? -72.333  39.453 14.877  0.42 42.83  ? 1037 SER A CB  1 
ATOM   1496 O OG  A SER A 1 187 ? -72.939  38.240 15.163  0.58 43.57  ? 1037 SER A OG  1 
ATOM   1497 O OG  B SER A 1 187 ? -71.600  39.084 13.720  0.42 36.72  ? 1037 SER A OG  1 
ATOM   1498 N N   . ILE A 1 188 ? -73.150  42.162 16.412  1.00 41.23  ? 1038 ILE A N   1 
ATOM   1499 C CA  . ILE A 1 188 ? -73.581  42.829 17.644  1.00 41.90  ? 1038 ILE A CA  1 
ATOM   1500 C C   . ILE A 1 188 ? -74.769  43.755 17.389  1.00 46.16  ? 1038 ILE A C   1 
ATOM   1501 O O   . ILE A 1 188 ? -75.675  43.863 18.225  1.00 39.04  ? 1038 ILE A O   1 
ATOM   1502 C CB  . ILE A 1 188 ? -72.396  43.584 18.275  1.00 42.63  ? 1038 ILE A CB  1 
ATOM   1503 C CG1 . ILE A 1 188 ? -71.255  42.616 18.595  1.00 43.07  ? 1038 ILE A CG1 1 
ATOM   1504 C CG2 . ILE A 1 188 ? -72.836  44.382 19.499  1.00 47.95  ? 1038 ILE A CG2 1 
ATOM   1505 C CD1 . ILE A 1 188 ? -69.978  43.302 19.022  1.00 40.95  ? 1038 ILE A CD1 1 
ATOM   1506 N N   . LEU A 1 189 ? -74.793  44.415 16.226  1.00 38.10  ? 1039 LEU A N   1 
ATOM   1507 C CA  . LEU A 1 189 ? -75.765  45.472 15.944  1.00 41.37  ? 1039 LEU A CA  1 
ATOM   1508 C C   . LEU A 1 189 ? -77.193  45.024 16.213  1.00 44.60  ? 1039 LEU A C   1 
ATOM   1509 O O   . LEU A 1 189 ? -77.965  45.736 16.867  1.00 43.85  ? 1039 LEU A O   1 
ATOM   1510 C CB  . LEU A 1 189 ? -75.649  45.920 14.486  1.00 35.50  ? 1039 LEU A CB  1 
ATOM   1511 C CG  . LEU A 1 189 ? -76.288  47.262 14.107  1.00 36.67  ? 1039 LEU A CG  1 
ATOM   1512 C CD1 . LEU A 1 189 ? -75.907  48.399 15.052  1.00 39.96  ? 1039 LEU A CD1 1 
ATOM   1513 C CD2 . LEU A 1 189 ? -76.001  47.616 12.654  1.00 34.86  ? 1039 LEU A CD2 1 
ATOM   1514 N N   . GLY A 1 190 ? -77.582  43.877 15.662  1.00 40.89  ? 1040 GLY A N   1 
ATOM   1515 C CA  . GLY A 1 190 ? -78.952  43.454 15.828  1.00 45.17  ? 1040 GLY A CA  1 
ATOM   1516 C C   . GLY A 1 190 ? -79.264  42.688 17.091  1.00 53.72  ? 1040 GLY A C   1 
ATOM   1517 O O   . GLY A 1 190 ? -80.389  42.205 17.238  1.00 52.86  ? 1040 GLY A O   1 
ATOM   1518 N N   . SER A 1 191 ? -78.347  42.645 18.053  1.00 46.26  ? 1041 SER A N   1 
ATOM   1519 C CA  . SER A 1 191 ? -78.600  41.936 19.298  1.00 49.58  ? 1041 SER A CA  1 
ATOM   1520 C C   . SER A 1 191 ? -79.491  42.770 20.208  1.00 52.28  ? 1041 SER A C   1 
ATOM   1521 O O   . SER A 1 191 ? -79.380  43.998 20.254  1.00 47.79  ? 1041 SER A O   1 
ATOM   1522 C CB  . SER A 1 191 ? -77.297  41.605 20.020  1.00 52.95  ? 1041 SER A CB  1 
ATOM   1523 O OG  . SER A 1 191 ? -77.575  41.024 21.283  1.00 49.78  ? 1041 SER A OG  1 
ATOM   1524 N N   . ALA A 1 192 ? -80.423  42.094 20.881  1.00 57.22  ? 1042 ALA A N   1 
ATOM   1525 C CA  . ALA A 1 192 ? -81.311  42.699 21.868  1.00 51.71  ? 1042 ALA A CA  1 
ATOM   1526 C C   . ALA A 1 192 ? -80.687  42.846 23.256  1.00 59.98  ? 1042 ALA A C   1 
ATOM   1527 O O   . ALA A 1 192 ? -81.311  43.460 24.128  1.00 62.54  ? 1042 ALA A O   1 
ATOM   1528 C CB  . ALA A 1 192 ? -82.622  41.921 21.950  1.00 58.58  ? 1042 ALA A CB  1 
ATOM   1529 N N   . LYS A 1 193 ? -79.512  42.268 23.502  1.00 57.85  ? 1043 LYS A N   1 
ATOM   1530 C CA  . LYS A 1 193 ? -78.929  42.282 24.838  1.00 54.69  ? 1043 LYS A CA  1 
ATOM   1531 C C   . LYS A 1 193 ? -78.432  43.684 25.172  1.00 59.52  ? 1043 LYS A C   1 
ATOM   1532 O O   . LYS A 1 193 ? -78.159  44.497 24.285  1.00 58.83  ? 1043 LYS A O   1 
ATOM   1533 C CB  . LYS A 1 193 ? -77.772  41.290 24.951  1.00 55.88  ? 1043 LYS A CB  1 
ATOM   1534 C CG  . LYS A 1 193 ? -78.178  39.844 24.779  1.00 53.95  ? 1043 LYS A CG  1 
ATOM   1535 C CD  . LYS A 1 193 ? -76.984  38.903 24.783  1.00 59.42  ? 1043 LYS A CD  1 
ATOM   1536 C CE  . LYS A 1 193 ? -76.246  38.937 23.457  1.00 59.97  ? 1043 LYS A CE  1 
ATOM   1537 N NZ  . LYS A 1 193 ? -74.984  38.154 23.495  1.00 57.46  ? 1043 LYS A NZ  1 
ATOM   1538 N N   . HIS A 1 194 ? -78.459  44.005 26.461  1.00 61.41  ? 1044 HIS A N   1 
ATOM   1539 C CA  . HIS A 1 194 ? -78.143  45.335 26.959  1.00 63.50  ? 1044 HIS A CA  1 
ATOM   1540 C C   . HIS A 1 194 ? -76.712  45.400 27.485  1.00 57.08  ? 1044 HIS A C   1 
ATOM   1541 O O   . HIS A 1 194 ? -76.254  44.486 28.177  1.00 60.20  ? 1044 HIS A O   1 
ATOM   1542 C CB  . HIS A 1 194 ? -79.126  45.714 28.061  1.00 67.38  ? 1044 HIS A CB  1 
ATOM   1543 C CG  . HIS A 1 194 ? -80.445  46.191 27.539  1.00 76.03  ? 1044 HIS A CG  1 
ATOM   1544 N ND1 . HIS A 1 194 ? -80.567  47.015 26.440  1.00 79.49  ? 1044 HIS A ND1 1 
ATOM   1545 C CD2 . HIS A 1 194 ? -81.706  45.935 27.959  1.00 79.20  ? 1044 HIS A CD2 1 
ATOM   1546 C CE1 . HIS A 1 194 ? -81.848  47.251 26.211  1.00 82.69  ? 1044 HIS A CE1 1 
ATOM   1547 N NE2 . HIS A 1 194 ? -82.559  46.609 27.120  1.00 79.35  ? 1044 HIS A NE2 1 
ATOM   1548 N N   . GLY A 1 195 ? -76.003  46.470 27.144  1.00 56.66  ? 1045 GLY A N   1 
ATOM   1549 C CA  . GLY A 1 195 ? -74.665  46.660 27.666  1.00 58.28  ? 1045 GLY A CA  1 
ATOM   1550 C C   . GLY A 1 195 ? -73.590  46.176 26.716  1.00 56.21  ? 1045 GLY A C   1 
ATOM   1551 O O   . GLY A 1 195 ? -73.821  45.873 25.542  1.00 52.77  ? 1045 GLY A O   1 
ATOM   1552 N N   . LEU A 1 196 ? -72.377  46.125 27.255  1.00 53.09  ? 1046 LEU A N   1 
ATOM   1553 C CA  . LEU A 1 196 ? -71.201  45.710 26.506  1.00 51.88  ? 1046 LEU A CA  1 
ATOM   1554 C C   . LEU A 1 196 ? -71.051  44.196 26.572  1.00 45.96  ? 1046 LEU A C   1 
ATOM   1555 O O   . LEU A 1 196 ? -70.938  43.623 27.662  1.00 50.34  ? 1046 LEU A O   1 
ATOM   1556 C CB  . LEU A 1 196 ? -69.941  46.377 27.055  1.00 50.06  ? 1046 LEU A CB  1 
ATOM   1557 C CG  . LEU A 1 196 ? -68.673  46.154 26.225  1.00 50.36  ? 1046 LEU A CG  1 
ATOM   1558 C CD1 . LEU A 1 196 ? -68.716  46.957 24.934  1.00 47.88  ? 1046 LEU A CD1 1 
ATOM   1559 C CD2 . LEU A 1 196 ? -67.421  46.469 27.025  1.00 52.84  ? 1046 LEU A CD2 1 
ATOM   1560 N N   . TYR A 1 197 ? -71.055  43.554 25.409  1.00 45.77  ? 1047 TYR A N   1 
ATOM   1561 C CA  . TYR A 1 197 ? -70.784  42.131 25.295  1.00 44.94  ? 1047 TYR A CA  1 
ATOM   1562 C C   . TYR A 1 197 ? -69.560  41.973 24.406  1.00 43.38  ? 1047 TYR A C   1 
ATOM   1563 O O   . TYR A 1 197 ? -69.458  42.617 23.358  1.00 42.67  ? 1047 TYR A O   1 
ATOM   1564 C CB  . TYR A 1 197 ? -71.982  41.367 24.704  1.00 45.27  ? 1047 TYR A CB  1 
ATOM   1565 C CG  . TYR A 1 197 ? -73.077  41.071 25.706  1.00 46.77  ? 1047 TYR A CG  1 
ATOM   1566 C CD1 . TYR A 1 197 ? -73.937  42.070 26.146  1.00 49.60  ? 1047 TYR A CD1 1 
ATOM   1567 C CD2 . TYR A 1 197 ? -73.240  39.793 26.223  1.00 47.39  ? 1047 TYR A CD2 1 
ATOM   1568 C CE1 . TYR A 1 197 ? -74.934  41.799 27.069  1.00 54.26  ? 1047 TYR A CE1 1 
ATOM   1569 C CE2 . TYR A 1 197 ? -74.231  39.514 27.144  1.00 50.47  ? 1047 TYR A CE2 1 
ATOM   1570 C CZ  . TYR A 1 197 ? -75.075  40.518 27.564  1.00 52.75  ? 1047 TYR A CZ  1 
ATOM   1571 O OH  . TYR A 1 197 ? -76.061  40.236 28.482  1.00 56.94  ? 1047 TYR A OH  1 
ATOM   1572 N N   . LEU A 1 198 ? -68.634  41.139 24.833  1.00 44.50  ? 1048 LEU A N   1 
ATOM   1573 C CA  . LEU A 1 198 ? -67.388  40.945 24.057  1.00 42.75  ? 1048 LEU A CA  1 
ATOM   1574 C C   . LEU A 1 198 ? -67.272  39.487 23.620  1.00 35.15  ? 1048 LEU A C   1 
ATOM   1575 O O   . LEU A 1 198 ? -67.746  38.606 24.314  1.00 36.58  ? 1048 LEU A O   1 
ATOM   1576 C CB  . LEU A 1 198 ? -66.193  41.355 24.912  1.00 41.88  ? 1048 LEU A CB  1 
ATOM   1577 C CG  . LEU A 1 198 ? -66.147  42.815 25.348  1.00 48.51  ? 1048 LEU A CG  1 
ATOM   1578 C CD1 . LEU A 1 198 ? -64.816  43.123 26.008  1.00 50.32  ? 1048 LEU A CD1 1 
ATOM   1579 C CD2 . LEU A 1 198 ? -66.375  43.733 24.164  1.00 49.81  ? 1048 LEU A CD2 1 
ATOM   1580 N N   . PRO A 1 199 ? -66.632  39.237 22.470  1.00 36.94  ? 1049 PRO A N   1 
ATOM   1581 C CA  . PRO A 1 199 ? -66.458  37.875 22.012  1.00 34.38  ? 1049 PRO A CA  1 
ATOM   1582 C C   . PRO A 1 199 ? -65.660  37.038 23.016  1.00 35.42  ? 1049 PRO A C   1 
ATOM   1583 O O   . PRO A 1 199 ? -64.706  37.523 23.539  1.00 40.16  ? 1049 PRO A O   1 
ATOM   1584 C CB  . PRO A 1 199 ? -65.714  38.094 20.697  1.00 35.11  ? 1049 PRO A CB  1 
ATOM   1585 C CG  . PRO A 1 199 ? -66.074  39.485 20.267  1.00 39.16  ? 1049 PRO A CG  1 
ATOM   1586 C CD  . PRO A 1 199 ? -66.110  40.251 21.566  1.00 37.44  ? 1049 PRO A CD  1 
ATOM   1587 N N   . THR A 1 200 ? -66.096  35.814 23.263  1.00 32.93  ? 1050 THR A N   1 
ATOM   1588 C CA  . THR A 1 200 ? -65.387  34.895 24.174  1.00 31.14  ? 1050 THR A CA  1 
ATOM   1589 C C   . THR A 1 200 ? -65.080  33.600 23.425  1.00 36.78  ? 1050 THR A C   1 
ATOM   1590 O O   . THR A 1 200 ? -64.115  32.944 23.782  1.00 35.26  ? 1050 THR A O   1 
ATOM   1591 C CB  . THR A 1 200 ? -66.221  34.621 25.431  1.00 38.78  ? 1050 THR A CB  1 
ATOM   1592 O OG1 . THR A 1 200 ? -67.452  34.007 25.059  1.00 40.64  ? 1050 THR A OG1 1 
ATOM   1593 C CG2 . THR A 1 200 ? -66.470  35.882 26.225  1.00 40.83  ? 1050 THR A CG2 1 
ATOM   1594 N N   . ARG A 1 201 ? -65.893  33.268 22.418  1.00 32.17  ? 1051 ARG A N   1 
ATOM   1595 C CA  . ARG A 1 201 ? -65.698  32.019 21.655  1.00 33.09  ? 1051 ARG A CA  1 
ATOM   1596 C C   . ARG A 1 201 ? -66.147  32.165 20.205  1.00 33.14  ? 1051 ARG A C   1 
ATOM   1597 O O   . ARG A 1 201 ? -67.012  32.987 19.954  1.00 36.40  ? 1051 ARG A O   1 
ATOM   1598 C CB  . ARG A 1 201 ? -66.472  30.862 22.287  1.00 40.76  ? 1051 ARG A CB  1 
ATOM   1599 C CG  . ARG A 1 201 ? -65.773  30.181 23.452  1.00 47.34  ? 1051 ARG A CG  1 
ATOM   1600 C CD  . ARG A 1 201 ? -66.767  29.885 24.551  1.00 51.52  ? 1051 ARG A CD  1 
ATOM   1601 N NE  . ARG A 1 201 ? -68.015  29.375 24.009  1.00 63.36  ? 1051 ARG A NE  1 
ATOM   1602 C CZ  . ARG A 1 201 ? -69.129  29.210 24.712  1.00 66.40  ? 1051 ARG A CZ  1 
ATOM   1603 N NH1 . ARG A 1 201 ? -69.198  29.647 25.955  1.00 67.86  ? 1051 ARG A NH1 1 
ATOM   1604 N NH2 . ARG A 1 201 ? -70.177  28.624 24.162  1.00 57.82  ? 1051 ARG A NH2 1 
ATOM   1605 N N   . VAL A 1 202 ? -65.511  31.422 19.311  1.00 32.35  ? 1052 VAL A N   1 
ATOM   1606 C CA  . VAL A 1 202 ? -65.935  31.350 17.886  1.00 31.92  ? 1052 VAL A CA  1 
ATOM   1607 C C   . VAL A 1 202 ? -65.697  29.906 17.457  1.00 35.06  ? 1052 VAL A C   1 
ATOM   1608 O O   . VAL A 1 202 ? -64.579  29.441 17.586  1.00 32.77  ? 1052 VAL A O   1 
ATOM   1609 C CB  . VAL A 1 202 ? -65.229  32.342 16.945  1.00 33.37  ? 1052 VAL A CB  1 
ATOM   1610 C CG1 . VAL A 1 202 ? -65.896  32.357 15.581  1.00 28.85  ? 1052 VAL A CG1 1 
ATOM   1611 C CG2 . VAL A 1 202 ? -65.160  33.743 17.522  1.00 35.74  ? 1052 VAL A CG2 1 
ATOM   1612 N N   . THR A 1 203 ? -66.732  29.241 16.972  1.00 30.39  ? 1053 THR A N   1 
ATOM   1613 C CA  . THR A 1 203 ? -66.609  27.797 16.645  1.00 31.40  ? 1053 THR A CA  1 
ATOM   1614 C C   . THR A 1 203 ? -65.732  27.590 15.407  1.00 31.10  ? 1053 THR A C   1 
ATOM   1615 O O   . THR A 1 203 ? -64.931  26.679 15.413  1.00 32.36  ? 1053 THR A O   1 
ATOM   1616 C CB  . THR A 1 203 ? -67.995  27.138 16.545  1.00 34.22  ? 1053 THR A CB  1 
ATOM   1617 O OG1 . THR A 1 203 ? -68.743  27.508 17.700  1.00 36.01  ? 1053 THR A OG1 1 
ATOM   1618 C CG2 . THR A 1 203 ? -67.918  25.635 16.408  1.00 38.47  ? 1053 THR A CG2 1 
ATOM   1619 N N   . ALA A 1 204 ? -65.938  28.410 14.386  1.00 33.05  ? 1054 ALA A N   1 
ATOM   1620 C CA  . ALA A 1 204 ? -65.151  28.265 13.152  1.00 31.13  ? 1054 ALA A CA  1 
ATOM   1621 C C   . ALA A 1 204 ? -65.122  29.538 12.324  1.00 34.72  ? 1054 ALA A C   1 
ATOM   1622 O O   . ALA A 1 204 ? -66.147  30.200 12.231  1.00 33.88  ? 1054 ALA A O   1 
ATOM   1623 C CB  . ALA A 1 204 ? -65.665  27.132 12.327  1.00 34.44  ? 1054 ALA A CB  1 
ATOM   1624 N N   . ILE A 1 205 ? -63.955  29.838 11.780  1.00 26.82  ? 1055 ILE A N   1 
ATOM   1625 C CA  . ILE A 1 205 ? -63.790  30.956 10.858  1.00 27.97  ? 1055 ILE A CA  1 
ATOM   1626 C C   . ILE A 1 205 ? -63.050  30.448 9.633   1.00 31.58  ? 1055 ILE A C   1 
ATOM   1627 O O   . ILE A 1 205 ? -61.980  29.848 9.757   1.00 29.27  ? 1055 ILE A O   1 
ATOM   1628 C CB  . ILE A 1 205 ? -63.018  32.132 11.484  1.00 28.53  ? 1055 ILE A CB  1 
ATOM   1629 C CG1 . ILE A 1 205 ? -63.778  32.709 12.674  1.00 30.47  ? 1055 ILE A CG1 1 
ATOM   1630 C CG2 . ILE A 1 205 ? -62.762  33.218 10.442  1.00 27.00  ? 1055 ILE A CG2 1 
ATOM   1631 C CD1 . ILE A 1 205 ? -62.884  33.418 13.647  1.00 33.74  ? 1055 ILE A CD1 1 
ATOM   1632 N N   . HIS A 1 206 ? -63.620  30.676 8.458   1.00 28.59  ? 1056 HIS A N   1 
ATOM   1633 C CA  . HIS A 1 206 ? -62.963  30.360 7.198   1.00 26.78  ? 1056 HIS A CA  1 
ATOM   1634 C C   . HIS A 1 206 ? -62.624  31.652 6.470   1.00 27.88  ? 1056 HIS A C   1 
ATOM   1635 O O   . HIS A 1 206 ? -63.457  32.563 6.388   1.00 29.54  ? 1056 HIS A O   1 
ATOM   1636 C CB  . HIS A 1 206 ? -63.848  29.490 6.303   1.00 25.81  ? 1056 HIS A CB  1 
ATOM   1637 C CG  . HIS A 1 206 ? -64.060  28.098 6.811   1.00 27.69  ? 1056 HIS A CG  1 
ATOM   1638 N ND1 . HIS A 1 206 ? -64.830  27.817 7.918   1.00 31.86  ? 1056 HIS A ND1 1 
ATOM   1639 C CD2 . HIS A 1 206 ? -63.625  26.904 6.342   1.00 31.53  ? 1056 HIS A CD2 1 
ATOM   1640 C CE1 . HIS A 1 206 ? -64.853  26.511 8.117   1.00 31.49  ? 1056 HIS A CE1 1 
ATOM   1641 N NE2 . HIS A 1 206 ? -64.129  25.934 7.175   1.00 30.45  ? 1056 HIS A NE2 1 
ATOM   1642 N N   . ILE A 1 207 ? -61.406  31.733 5.940   1.00 26.17  ? 1057 ILE A N   1 
ATOM   1643 C CA  . ILE A 1 207 ? -60.990  32.870 5.128   1.00 24.61  ? 1057 ILE A CA  1 
ATOM   1644 C C   . ILE A 1 207 ? -60.410  32.348 3.824   1.00 33.26  ? 1057 ILE A C   1 
ATOM   1645 O O   . ILE A 1 207 ? -59.527  31.480 3.836   1.00 31.37  ? 1057 ILE A O   1 
ATOM   1646 C CB  . ILE A 1 207 ? -59.954  33.762 5.838   1.00 27.49  ? 1057 ILE A CB  1 
ATOM   1647 C CG1 . ILE A 1 207 ? -60.456  34.205 7.213   1.00 28.66  ? 1057 ILE A CG1 1 
ATOM   1648 C CG2 . ILE A 1 207 ? -59.648  34.981 4.978   1.00 28.08  ? 1057 ILE A CG2 1 
ATOM   1649 C CD1 . ILE A 1 207 ? -59.427  34.989 8.006   1.00 29.44  ? 1057 ILE A CD1 1 
ATOM   1650 N N   . ASP A 1 208 ? -60.912  32.865 2.704   1.00 27.59  ? 1058 ASP A N   1 
ATOM   1651 C CA  . ASP A 1 208 ? -60.347  32.575 1.388   1.00 29.99  ? 1058 ASP A CA  1 
ATOM   1652 C C   . ASP A 1 208 ? -60.036  33.883 0.673   1.00 31.78  ? 1058 ASP A C   1 
ATOM   1653 O O   . ASP A 1 208 ? -60.945  34.517 0.109   1.00 30.13  ? 1058 ASP A O   1 
ATOM   1654 C CB  . ASP A 1 208 ? -61.280  31.727 0.537   1.00 35.86  ? 1058 ASP A CB  1 
ATOM   1655 C CG  . ASP A 1 208 ? -60.677  31.402 -0.813  1.00 40.27  ? 1058 ASP A CG  1 
ATOM   1656 O OD1 . ASP A 1 208 ? -59.449  31.577 -0.961  1.00 39.00  ? 1058 ASP A OD1 1 
ATOM   1657 O OD2 . ASP A 1 208 ? -61.421  31.000 -1.729  1.00 36.81  ? 1058 ASP A OD2 1 
ATOM   1658 N N   . PRO A 1 209 ? -58.769  34.303 0.645   1.00 30.94  ? 1059 PRO A N   1 
ATOM   1659 C CA  . PRO A 1 209 ? -58.435  35.581 -0.005  1.00 29.24  ? 1059 PRO A CA  1 
ATOM   1660 C C   . PRO A 1 209 ? -58.823  35.652 -1.482  1.00 31.05  ? 1059 PRO A C   1 
ATOM   1661 O O   . PRO A 1 209 ? -59.175  36.737 -1.968  1.00 31.27  ? 1059 PRO A O   1 
ATOM   1662 C CB  . PRO A 1 209 ? -56.916  35.668 0.200   1.00 33.10  ? 1059 PRO A CB  1 
ATOM   1663 C CG  . PRO A 1 209 ? -56.697  34.923 1.498   1.00 33.02  ? 1059 PRO A CG  1 
ATOM   1664 C CD  . PRO A 1 209 ? -57.619  33.740 1.376   1.00 31.85  ? 1059 PRO A CD  1 
ATOM   1665 N N   . ALA A 1 210 ? -58.873  34.537 -2.178  1.00 33.76  ? 1060 ALA A N   1 
ATOM   1666 C CA  . ALA A 1 210 ? -59.192  34.648 -3.614  1.00 36.45  ? 1060 ALA A CA  1 
ATOM   1667 C C   . ALA A 1 210 ? -60.673  34.983 -3.773  1.00 34.09  ? 1060 ALA A C   1 
ATOM   1668 O O   . ALA A 1 210 ? -61.006  35.881 -4.533  1.00 36.81  ? 1060 ALA A O   1 
ATOM   1669 C CB  . ALA A 1 210 ? -58.869  33.359 -4.289  1.00 37.57  ? 1060 ALA A CB  1 
ATOM   1670 N N   . THR A 1 211 ? -61.503  34.270 -3.032  1.00 32.57  ? 1061 THR A N   1 
ATOM   1671 C CA  . THR A 1 211 ? -62.959  34.517 -3.102  1.00 33.77  ? 1061 THR A CA  1 
ATOM   1672 C C   . THR A 1 211 ? -63.221  35.956 -2.649  1.00 34.17  ? 1061 THR A C   1 
ATOM   1673 O O   . THR A 1 211 ? -64.049  36.621 -3.244  1.00 34.18  ? 1061 THR A O   1 
ATOM   1674 C CB  . THR A 1 211 ? -63.726  33.413 -2.359  1.00 36.11  ? 1061 THR A CB  1 
ATOM   1675 O OG1 . THR A 1 211 ? -63.486  32.144 -2.960  1.00 34.31  ? 1061 THR A OG1 1 
ATOM   1676 C CG2 . THR A 1 211 ? -65.213  33.691 -2.304  1.00 35.59  ? 1061 THR A CG2 1 
ATOM   1677 N N   . HIS A 1 212 ? -62.488  36.409 -1.644  1.00 31.39  ? 1062 HIS A N   1 
ATOM   1678 C CA  . HIS A 1 212 ? -62.646  37.789 -1.126  1.00 28.18  ? 1062 HIS A CA  1 
ATOM   1679 C C   . HIS A 1 212 ? -62.446  38.810 -2.241  1.00 33.22  ? 1062 HIS A C   1 
ATOM   1680 O O   . HIS A 1 212 ? -63.263  39.697 -2.417  1.00 31.27  ? 1062 HIS A O   1 
ATOM   1681 C CB  . HIS A 1 212 ? -61.612  38.062 -0.033  1.00 30.21  ? 1062 HIS A CB  1 
ATOM   1682 C CG  . HIS A 1 212 ? -61.810  39.321 0.730   1.00 29.15  ? 1062 HIS A CG  1 
ATOM   1683 N ND1 . HIS A 1 212 ? -62.872  39.523 1.578   1.00 28.27  ? 1062 HIS A ND1 1 
ATOM   1684 C CD2 . HIS A 1 212 ? -61.062  40.418 0.807   1.00 31.55  ? 1062 HIS A CD2 1 
ATOM   1685 C CE1 . HIS A 1 212 ? -62.769  40.720 2.118   1.00 31.18  ? 1062 HIS A CE1 1 
ATOM   1686 N NE2 . HIS A 1 212 ? -61.677  41.280 1.666   1.00 32.29  ? 1062 HIS A NE2 1 
ATOM   1687 N N   . ARG A 1 213 ? -61.366  38.642 -2.993  1.00 32.69  ? 1063 ARG A N   1 
ATOM   1688 C CA  . ARG A 1 213 ? -61.043  39.608 -4.066  1.00 36.57  ? 1063 ARG A CA  1 
ATOM   1689 C C   . ARG A 1 213 ? -62.138  39.590 -5.142  1.00 32.01  ? 1063 ARG A C   1 
ATOM   1690 O O   . ARG A 1 213 ? -62.370  40.619 -5.748  1.00 40.57  ? 1063 ARG A O   1 
ATOM   1691 C CB  . ARG A 1 213 ? -59.657  39.292 -4.636  1.00 43.21  ? 1063 ARG A CB  1 
ATOM   1692 C CG  . ARG A 1 213 ? -58.513  39.400 -3.638  1.00 48.87  ? 1063 ARG A CG  1 
ATOM   1693 C CD  . ARG A 1 213 ? -58.267  40.808 -3.133  1.00 56.81  ? 1063 ARG A CD  1 
ATOM   1694 N NE  . ARG A 1 213 ? -57.131  40.898 -2.225  1.00 61.74  ? 1063 ARG A NE  1 
ATOM   1695 C CZ  . ARG A 1 213 ? -56.764  42.005 -1.592  1.00 57.90  ? 1063 ARG A CZ  1 
ATOM   1696 N NH1 . ARG A 1 213 ? -57.287  43.166 -1.935  1.00 58.63  ? 1063 ARG A NH1 1 
ATOM   1697 N NH2 . ARG A 1 213 ? -55.880  41.948 -0.614  1.00 59.06  ? 1063 ARG A NH2 1 
ATOM   1698 N N   . GLN A 1 214 ? -62.753  38.446 -5.367  1.00 33.06  ? 1064 GLN A N   1 
ATOM   1699 C CA  . GLN A 1 214 ? -63.849  38.338 -6.353  1.00 40.75  ? 1064 GLN A CA  1 
ATOM   1700 C C   . GLN A 1 214 ? -65.110  39.024 -5.839  1.00 41.79  ? 1064 GLN A C   1 
ATOM   1701 O O   . GLN A 1 214 ? -65.825  39.589 -6.650  1.00 40.57  ? 1064 GLN A O   1 
ATOM   1702 C CB  . GLN A 1 214 ? -64.253  36.884 -6.557  1.00 44.83  ? 1064 GLN A CB  1 
ATOM   1703 C CG  . GLN A 1 214 ? -63.180  36.001 -7.165  1.00 55.65  ? 1064 GLN A CG  1 
ATOM   1704 C CD  . GLN A 1 214 ? -63.739  34.620 -7.395  1.00 64.87  ? 1064 GLN A CD  1 
ATOM   1705 O OE1 . GLN A 1 214 ? -64.914  34.359 -7.144  1.00 71.92  ? 1064 GLN A OE1 1 
ATOM   1706 N NE2 . GLN A 1 214 ? -62.901  33.721 -7.883  1.00 69.23  ? 1064 GLN A NE2 1 
ATOM   1707 N N   . LYS A 1 215 ? -65.366  38.947 -4.543  1.00 38.91  ? 1065 LYS A N   1 
ATOM   1708 C CA  . LYS A 1 215 ? -66.655  39.441 -4.003  1.00 36.88  ? 1065 LYS A CA  1 
ATOM   1709 C C   . LYS A 1 215 ? -66.625  40.953 -3.755  1.00 36.09  ? 1065 LYS A C   1 
ATOM   1710 O O   . LYS A 1 215 ? -67.682  41.532 -3.576  1.00 37.59  ? 1065 LYS A O   1 
ATOM   1711 C CB  . LYS A 1 215 ? -67.009  38.586 -2.789  1.00 37.93  ? 1065 LYS A CB  1 
ATOM   1712 C CG  . LYS A 1 215 ? -67.272  37.124 -3.112  1.00 40.74  ? 1065 LYS A CG  1 
ATOM   1713 C CD  . LYS A 1 215 ? -68.370  36.497 -2.299  1.00 43.74  ? 1065 LYS A CD  1 
ATOM   1714 C CE  . LYS A 1 215 ? -69.719  37.138 -2.532  1.00 43.40  ? 1065 LYS A CE  1 
ATOM   1715 N NZ  . LYS A 1 215 ? -70.767  36.501 -1.705  1.00 43.76  ? 1065 LYS A NZ  1 
ATOM   1716 N N   . LEU A 1 216 ? -65.445  41.541 -3.748  1.00 34.22  ? 1066 LEU A N   1 
ATOM   1717 C CA  . LEU A 1 216 ? -65.331  42.997 -3.539  1.00 31.06  ? 1066 LEU A CA  1 
ATOM   1718 C C   . LEU A 1 216 ? -65.889  43.723 -4.760  1.00 39.15  ? 1066 LEU A C   1 
ATOM   1719 O O   . LEU A 1 216 ? -65.778  43.182 -5.858  1.00 38.79  ? 1066 LEU A O   1 
ATOM   1720 C CB  . LEU A 1 216 ? -63.871  43.378 -3.337  1.00 35.29  ? 1066 LEU A CB  1 
ATOM   1721 C CG  . LEU A 1 216 ? -63.213  42.902 -2.046  1.00 37.68  ? 1066 LEU A CG  1 
ATOM   1722 C CD1 . LEU A 1 216 ? -61.732  43.236 -2.061  1.00 37.08  ? 1066 LEU A CD1 1 
ATOM   1723 C CD2 . LEU A 1 216 ? -63.875  43.546 -0.845  1.00 32.04  ? 1066 LEU A CD2 1 
ATOM   1724 N N   . TYR A 1 217 ? -66.483  44.879 -4.537  1.00 34.05  ? 1067 TYR A N   1 
ATOM   1725 C CA  . TYR A 1 217 ? -66.955  45.714 -5.659  1.00 42.58  ? 1067 TYR A CA  1 
ATOM   1726 C C   . TYR A 1 217 ? -66.578  47.163 -5.373  1.00 41.54  ? 1067 TYR A C   1 
ATOM   1727 O O   . TYR A 1 217 ? -66.317  47.489 -4.229  1.00 40.73  ? 1067 TYR A O   1 
ATOM   1728 C CB  . TYR A 1 217 ? -68.441  45.527 -5.965  1.00 40.51  ? 1067 TYR A CB  1 
ATOM   1729 C CG  . TYR A 1 217 ? -69.468  45.817 -4.907  1.00 42.33  ? 1067 TYR A CG  1 
ATOM   1730 C CD1 . TYR A 1 217 ? -69.797  44.874 -3.951  1.00 43.92  ? 1067 TYR A CD1 1 
ATOM   1731 C CD2 . TYR A 1 217 ? -70.175  47.004 -4.920  1.00 37.29  ? 1067 TYR A CD2 1 
ATOM   1732 C CE1 . TYR A 1 217 ? -70.773  45.123 -3.003  1.00 37.95  ? 1067 TYR A CE1 1 
ATOM   1733 C CE2 . TYR A 1 217 ? -71.154  47.268 -3.982  1.00 44.52  ? 1067 TYR A CE2 1 
ATOM   1734 C CZ  . TYR A 1 217 ? -71.454  46.324 -3.020  1.00 40.96  ? 1067 TYR A CZ  1 
ATOM   1735 O OH  . TYR A 1 217 ? -72.418  46.592 -2.093  1.00 39.10  ? 1067 TYR A OH  1 
ATOM   1736 N N   . THR A 1 218 ? -66.581  47.984 -6.405  1.00 37.18  ? 1068 THR A N   1 
ATOM   1737 C CA  . THR A 1 218 ? -66.130  49.358 -6.257  1.00 39.67  ? 1068 THR A CA  1 
ATOM   1738 C C   . THR A 1 218 ? -67.305  50.306 -6.446  1.00 45.60  ? 1068 THR A C   1 
ATOM   1739 O O   . THR A 1 218 ? -68.045  50.199 -7.431  1.00 49.90  ? 1068 THR A O   1 
ATOM   1740 C CB  . THR A 1 218 ? -65.016  49.664 -7.264  1.00 45.79  ? 1068 THR A CB  1 
ATOM   1741 O OG1 . THR A 1 218 ? -64.105  48.558 -7.316  1.00 51.19  ? 1068 THR A OG1 1 
ATOM   1742 C CG2 . THR A 1 218 ? -64.258  50.911 -6.870  1.00 50.96  ? 1068 THR A CG2 1 
ATOM   1743 N N   . LEU A 1 219 ? -67.431  51.269 -5.538  1.00 45.38  ? 1069 LEU A N   1 
ATOM   1744 C CA  . LEU A 1 219 ? -68.451  52.298 -5.645  1.00 46.64  ? 1069 LEU A CA  1 
ATOM   1745 C C   . LEU A 1 219 ? -67.941  53.416 -6.542  1.00 53.15  ? 1069 LEU A C   1 
ATOM   1746 O O   . LEU A 1 219 ? -66.751  53.505 -6.850  1.00 52.48  ? 1069 LEU A O   1 
ATOM   1747 C CB  . LEU A 1 219 ? -68.848  52.841 -4.273  1.00 46.47  ? 1069 LEU A CB  1 
ATOM   1748 C CG  . LEU A 1 219 ? -69.166  51.855 -3.152  1.00 43.58  ? 1069 LEU A CG  1 
ATOM   1749 C CD1 . LEU A 1 219 ? -69.380  52.601 -1.843  1.00 41.64  ? 1069 LEU A CD1 1 
ATOM   1750 C CD2 . LEU A 1 219 ? -70.398  51.045 -3.508  1.00 48.02  ? 1069 LEU A CD2 1 
ATOM   1751 N N   . GLN A 1 220 ? -68.868  54.282 -6.963  1.00 55.07  ? 1070 GLN A N   1 
ATOM   1752 C CA  . GLN A 1 220 ? -68.509  55.357 -7.886  1.00 59.22  ? 1070 GLN A CA  1 
ATOM   1753 C C   . GLN A 1 220 ? -67.459  56.283 -7.304  1.00 56.07  ? 1070 GLN A C   1 
ATOM   1754 O O   . GLN A 1 220 ? -66.667  56.874 -8.051  1.00 57.50  ? 1070 GLN A O   1 
ATOM   1755 C CB  . GLN A 1 220 ? -69.764  56.110 -8.327  1.00 61.88  ? 1070 GLN A CB  1 
ATOM   1756 C CG  . GLN A 1 220 ? -70.292  57.198 -7.417  1.00 61.71  ? 1070 GLN A CG  1 
ATOM   1757 C CD  . GLN A 1 220 ? -71.614  57.754 -7.929  1.00 65.29  ? 1070 GLN A CD  1 
ATOM   1758 O OE1 . GLN A 1 220 ? -72.475  57.003 -8.387  1.00 66.02  ? 1070 GLN A OE1 1 
ATOM   1759 N NE2 . GLN A 1 220 ? -71.777  59.070 -7.861  1.00 62.63  ? 1070 GLN A NE2 1 
ATOM   1760 N N   . ASP A 1 221 ? -67.421  56.418 -5.992  1.00 57.91  ? 1071 ASP A N   1 
ATOM   1761 C CA  . ASP A 1 221 ? -66.310  57.145 -5.425  1.00 54.36  ? 1071 ASP A CA  1 
ATOM   1762 C C   . ASP A 1 221 ? -65.013  56.258 -5.310  1.00 53.90  ? 1071 ASP A C   1 
ATOM   1763 O O   . ASP A 1 221 ? -64.101  56.712 -4.631  1.00 55.46  ? 1071 ASP A O   1 
ATOM   1764 C CB  . ASP A 1 221 ? -66.748  57.783 -4.081  1.00 53.59  ? 1071 ASP A CB  1 
ATOM   1765 C CG  . ASP A 1 221 ? -66.712  56.824 -2.889  1.00 57.43  ? 1071 ASP A CG  1 
ATOM   1766 O OD1 . ASP A 1 221 ? -66.743  55.602 -3.109  1.00 54.46  ? 1071 ASP A OD1 1 
ATOM   1767 O OD2 . ASP A 1 221 ? -66.711  57.302 -1.725  1.00 64.03  ? 1071 ASP A OD2 1 
ATOM   1768 N N   . LYS A 1 222 ? -64.878  55.085 -5.979  1.00 52.17  ? 1072 LYS A N   1 
ATOM   1769 C CA  . LYS A 1 222 ? -63.689  54.215 -5.900  1.00 53.88  ? 1072 LYS A CA  1 
ATOM   1770 C C   . LYS A 1 222 ? -63.470  53.566 -4.520  1.00 54.66  ? 1072 LYS A C   1 
ATOM   1771 O O   . LYS A 1 222 ? -62.508  52.807 -4.356  1.00 49.13  ? 1072 LYS A O   1 
ATOM   1772 C CB  . LYS A 1 222 ? -62.495  54.912 -6.583  1.00 61.11  ? 1072 LYS A CB  1 
ATOM   1773 C CG  . LYS A 1 222 ? -63.162  55.772 -7.751  1.00 63.00  ? 1072 LYS A CG  1 
ATOM   1774 C CD  . LYS A 1 222 ? -63.137  55.129 -9.275  1.00 64.65  ? 1072 LYS A CD  1 
ATOM   1775 C CE  . LYS A 1 222 ? -63.391  56.247 -10.422 1.00 72.19  ? 1072 LYS A CE  1 
ATOM   1776 N NZ  . LYS A 1 222 ? -62.033  56.292 -11.083 1.00 79.09  ? 1072 LYS A NZ  1 
ATOM   1777 N N   . ALA A 1 223 ? -64.400  53.718 -3.571  1.00 47.74  ? 1073 ALA A N   1 
ATOM   1778 C CA  . ALA A 1 223 ? -64.314  52.883 -2.372  1.00 41.37  ? 1073 ALA A CA  1 
ATOM   1779 C C   . ALA A 1 223 ? -64.604  51.432 -2.734  1.00 42.07  ? 1073 ALA A C   1 
ATOM   1780 O O   . ALA A 1 223 ? -65.465  51.145 -3.570  1.00 41.14  ? 1073 ALA A O   1 
ATOM   1781 C CB  . ALA A 1 223 ? -65.288  53.347 -1.277  1.00 40.96  ? 1073 ALA A CB  1 
ATOM   1782 N N   . GLN A 1 224 ? -63.875  50.513 -2.110  1.00 37.25  ? 1074 GLN A N   1 
ATOM   1783 C CA  . GLN A 1 224 ? -64.111  49.088 -2.285  1.00 38.03  ? 1074 GLN A CA  1 
ATOM   1784 C C   . GLN A 1 224 ? -64.970  48.593 -1.136  1.00 34.91  ? 1074 GLN A C   1 
ATOM   1785 O O   . GLN A 1 224 ? -64.777  49.004 0.011   1.00 35.39  ? 1074 GLN A O   1 
ATOM   1786 C CB  . GLN A 1 224 ? -62.797  48.309 -2.313  1.00 40.47  ? 1074 GLN A CB  1 
ATOM   1787 C CG  . GLN A 1 224 ? -61.910  48.576 -3.508  1.00 40.51  ? 1074 GLN A CG  1 
ATOM   1788 C CD  . GLN A 1 224 ? -60.714  47.651 -3.525  1.00 40.80  ? 1074 GLN A CD  1 
ATOM   1789 O OE1 . GLN A 1 224 ? -59.659  47.975 -2.980  1.00 52.09  ? 1074 GLN A OE1 1 
ATOM   1790 N NE2 . GLN A 1 224 ? -60.879  46.481 -4.127  1.00 52.60  ? 1074 GLN A NE2 1 
ATOM   1791 N N   . VAL A 1 225 ? -65.916  47.704 -1.434  1.00 34.30  ? 1075 VAL A N   1 
ATOM   1792 C CA  . VAL A 1 225 ? -66.848  47.233 -0.420  1.00 33.30  ? 1075 VAL A CA  1 
ATOM   1793 C C   . VAL A 1 225 ? -67.177  45.767 -0.656  1.00 34.47  ? 1075 VAL A C   1 
ATOM   1794 O O   . VAL A 1 225 ? -66.999  45.227 -1.750  1.00 34.36  ? 1075 VAL A O   1 
ATOM   1795 C CB  . VAL A 1 225 ? -68.160  48.054 -0.387  1.00 34.64  ? 1075 VAL A CB  1 
ATOM   1796 C CG1 . VAL A 1 225 ? -67.884  49.504 -0.061  1.00 37.02  ? 1075 VAL A CG1 1 
ATOM   1797 C CG2 . VAL A 1 225 ? -68.883  47.945 -1.703  1.00 37.76  ? 1075 VAL A CG2 1 
ATOM   1798 N N   . ALA A 1 226 ? -67.668  45.134 0.403   1.00 31.11  ? 1076 ALA A N   1 
ATOM   1799 C CA  . ALA A 1 226 ? -68.253  43.804 0.335   1.00 30.69  ? 1076 ALA A CA  1 
ATOM   1800 C C   . ALA A 1 226 ? -69.557  43.818 1.115   1.00 35.59  ? 1076 ALA A C   1 
ATOM   1801 O O   . ALA A 1 226 ? -69.653  44.448 2.169   1.00 31.95  ? 1076 ALA A O   1 
ATOM   1802 C CB  . ALA A 1 226 ? -67.311  42.732 0.900   1.00 30.77  ? 1076 ALA A CB  1 
ATOM   1803 N N   . ASP A 1 227 ? -70.556  43.116 0.599   1.00 30.81  ? 1077 ASP A N   1 
ATOM   1804 C CA  . ASP A 1 227 ? -71.831  42.981 1.288   1.00 32.82  ? 1077 ASP A CA  1 
ATOM   1805 C C   . ASP A 1 227 ? -71.709  41.976 2.430   1.00 31.35  ? 1077 ASP A C   1 
ATOM   1806 O O   . ASP A 1 227 ? -70.976  40.989 2.327   1.00 30.75  ? 1077 ASP A O   1 
ATOM   1807 C CB  . ASP A 1 227 ? -72.907  42.547 0.296   1.00 35.03  ? 1077 ASP A CB  1 
ATOM   1808 C CG  . ASP A 1 227 ? -73.299  43.663 -0.659  1.00 38.38  ? 1077 ASP A CG  1 
ATOM   1809 O OD1 . ASP A 1 227 ? -72.971  44.837 -0.380  1.00 40.09  ? 1077 ASP A OD1 1 
ATOM   1810 O OD2 . ASP A 1 227 ? -73.895  43.359 -1.712  1.00 49.84  ? 1077 ASP A OD2 1 
ATOM   1811 N N   . VAL A 1 228 ? -72.393  42.251 3.541   1.00 30.43  ? 1078 VAL A N   1 
ATOM   1812 C CA  . VAL A 1 228 ? -72.397  41.369 4.704   1.00 29.86  ? 1078 VAL A CA  1 
ATOM   1813 C C   . VAL A 1 228 ? -73.820  40.909 4.996   1.00 31.29  ? 1078 VAL A C   1 
ATOM   1814 O O   . VAL A 1 228 ? -74.774  41.687 4.867   1.00 33.30  ? 1078 VAL A O   1 
ATOM   1815 C CB  . VAL A 1 228 ? -71.787  42.056 5.947   1.00 27.71  ? 1078 VAL A CB  1 
ATOM   1816 C CG1 . VAL A 1 228 ? -72.546  43.329 6.294   1.00 29.01  ? 1078 VAL A CG1 1 
ATOM   1817 C CG2 . VAL A 1 228 ? -71.773  41.103 7.137   1.00 26.98  ? 1078 VAL A CG2 1 
ATOM   1818 N N   . VAL A 1 229 ? -73.950  39.643 5.407   1.00 30.27  ? 1079 VAL A N   1 
ATOM   1819 C CA  . VAL A 1 229 ? -75.215  39.078 5.870   1.00 33.41  ? 1079 VAL A CA  1 
ATOM   1820 C C   . VAL A 1 229 ? -74.987  38.442 7.235   1.00 33.04  ? 1079 VAL A C   1 
ATOM   1821 O O   . VAL A 1 229 ? -73.981  37.754 7.454   1.00 31.94  ? 1079 VAL A O   1 
ATOM   1822 C CB  . VAL A 1 229 ? -75.799  38.044 4.880   1.00 36.15  ? 1079 VAL A CB  1 
ATOM   1823 C CG1 . VAL A 1 229 ? -76.923  37.238 5.536   1.00 39.67  ? 1079 VAL A CG1 1 
ATOM   1824 C CG2 . VAL A 1 229 ? -76.305  38.733 3.625   1.00 35.81  ? 1079 VAL A CG2 1 
ATOM   1825 N N   . VAL A 1 230 ? -75.913  38.692 8.160   1.00 30.09  ? 1080 VAL A N   1 
ATOM   1826 C CA  . VAL A 1 230 ? -75.910  38.090 9.489   1.00 34.45  ? 1080 VAL A CA  1 
ATOM   1827 C C   . VAL A 1 230 ? -77.177  37.263 9.657   1.00 40.85  ? 1080 VAL A C   1 
ATOM   1828 O O   . VAL A 1 230 ? -78.282  37.757 9.403   1.00 36.49  ? 1080 VAL A O   1 
ATOM   1829 C CB  . VAL A 1 230 ? -75.829  39.149 10.605  1.00 33.57  ? 1080 VAL A CB  1 
ATOM   1830 C CG1 . VAL A 1 230 ? -75.912  38.480 11.978  1.00 36.31  ? 1080 VAL A CG1 1 
ATOM   1831 C CG2 . VAL A 1 230 ? -74.567  39.984 10.477  1.00 34.13  ? 1080 VAL A CG2 1 
ATOM   1832 N N   . SER A 1 231 ? -77.017  35.997 10.041  1.00 35.89  ? 1081 SER A N   1 
ATOM   1833 C CA  . SER A 1 231 ? -78.132  35.139 10.433  1.00 40.06  ? 1081 SER A CA  1 
ATOM   1834 C C   . SER A 1 231 ? -77.858  34.695 11.868  1.00 41.64  ? 1081 SER A C   1 
ATOM   1835 O O   . SER A 1 231 ? -77.095  33.742 12.098  1.00 37.92  ? 1081 SER A O   1 
ATOM   1836 C CB  . SER A 1 231 ? -78.289  33.939 9.509   1.00 40.60  ? 1081 SER A CB  1 
ATOM   1837 O OG  . SER A 1 231 ? -79.228  33.029 10.057  1.00 42.03  ? 1081 SER A OG  1 
ATOM   1838 N N   . ARG A 1 232 ? -78.539  35.347 12.820  1.00 41.97  ? 1082 ARG A N   1 
ATOM   1839 C CA  . ARG A 1 232 ? -78.419  34.952 14.220  1.00 44.33  ? 1082 ARG A CA  1 
ATOM   1840 C C   . ARG A 1 232 ? -78.970  33.553 14.435  1.00 47.89  ? 1082 ARG A C   1 
ATOM   1841 O O   . ARG A 1 232 ? -78.440  32.788 15.250  1.00 45.45  ? 1082 ARG A O   1 
ATOM   1842 C CB  . ARG A 1 232 ? -79.175  35.937 15.120  1.00 49.72  ? 1082 ARG A CB  1 
ATOM   1843 C CG  . ARG A 1 232 ? -78.926  35.759 16.631  1.00 58.25  ? 1082 ARG A CG  1 
ATOM   1844 C CD  . ARG A 1 232 ? -79.218  37.027 17.440  1.00 62.17  ? 1082 ARG A CD  1 
ATOM   1845 N NE  . ARG A 1 232 ? -79.017  38.244 16.669  1.00 65.79  ? 1082 ARG A NE  1 
ATOM   1846 C CZ  . ARG A 1 232 ? -77.885  38.933 16.644  1.00 64.97  ? 1082 ARG A CZ  1 
ATOM   1847 N NH1 . ARG A 1 232 ? -76.825  38.547 17.337  1.00 65.67  ? 1082 ARG A NH1 1 
ATOM   1848 N NH2 . ARG A 1 232 ? -77.794  40.000 15.857  1.00 61.12  ? 1082 ARG A NH2 1 
ATOM   1849 N N   . TRP A 1 233 ? -80.042  33.210 13.721  1.00 42.40  ? 1083 TRP A N   1 
ATOM   1850 C CA  . TRP A 1 233 ? -80.605  31.864 13.786  1.00 43.31  ? 1083 TRP A CA  1 
ATOM   1851 C C   . TRP A 1 233 ? -79.572  30.805 13.416  1.00 43.71  ? 1083 TRP A C   1 
ATOM   1852 O O   . TRP A 1 233 ? -79.439  29.784 14.102  1.00 44.75  ? 1083 TRP A O   1 
ATOM   1853 C CB  . TRP A 1 233 ? -81.823  31.765 12.880  1.00 42.65  ? 1083 TRP A CB  1 
ATOM   1854 C CG  . TRP A 1 233 ? -82.442  30.418 12.892  1.00 42.03  ? 1083 TRP A CG  1 
ATOM   1855 C CD1 . TRP A 1 233 ? -82.354  29.460 11.929  1.00 45.40  ? 1083 TRP A CD1 1 
ATOM   1856 C CD2 . TRP A 1 233 ? -83.272  29.879 13.925  1.00 43.31  ? 1083 TRP A CD2 1 
ATOM   1857 N NE1 . TRP A 1 233 ? -83.072  28.349 12.302  1.00 43.30  ? 1083 TRP A NE1 1 
ATOM   1858 C CE2 . TRP A 1 233 ? -83.647  28.583 13.524  1.00 43.00  ? 1083 TRP A CE2 1 
ATOM   1859 C CE3 . TRP A 1 233 ? -83.732  30.366 15.152  1.00 43.62  ? 1083 TRP A CE3 1 
ATOM   1860 C CZ2 . TRP A 1 233 ? -84.461  27.767 14.306  1.00 49.29  ? 1083 TRP A CZ2 1 
ATOM   1861 C CZ3 . TRP A 1 233 ? -84.538  29.556 15.926  1.00 46.97  ? 1083 TRP A CZ3 1 
ATOM   1862 C CH2 . TRP A 1 233 ? -84.895  28.271 15.501  1.00 46.11  ? 1083 TRP A CH2 1 
ATOM   1863 N N   . LEU A 1 234 ? -78.853  31.020 12.313  1.00 36.65  ? 1084 LEU A N   1 
ATOM   1864 C CA  . LEU A 1 234 ? -77.882  30.061 11.849  1.00 39.67  ? 1084 LEU A CA  1 
ATOM   1865 C C   . LEU A 1 234 ? -76.498  30.247 12.534  1.00 35.05  ? 1084 LEU A C   1 
ATOM   1866 O O   . LEU A 1 234 ? -75.667  29.359 12.182  1.00 36.83  ? 1084 LEU A O   1 
ATOM   1867 C CB  . LEU A 1 234 ? -77.730  30.185 10.307  1.00 36.84  ? 1084 LEU A CB  1 
ATOM   1868 C CG  . LEU A 1 234 ? -78.938  29.831 9.441   1.00 38.69  ? 1084 LEU A CG  1 
ATOM   1869 C CD1 . LEU A 1 234 ? -78.581  29.951 7.973   1.00 38.66  ? 1084 LEU A CD1 1 
ATOM   1870 C CD2 . LEU A 1 234 ? -79.399  28.424 9.761   1.00 45.83  ? 1084 LEU A CD2 1 
ATOM   1871 N N   . ARG A 1 235 ? -76.298  31.294 13.309  1.00 34.56  ? 1085 ARG A N   1 
ATOM   1872 C CA  . ARG A 1 235 ? -75.005  31.539 13.988  1.00 43.16  ? 1085 ARG A CA  1 
ATOM   1873 C C   . ARG A 1 235 ? -73.932  31.733 12.910  1.00 38.27  ? 1085 ARG A C   1 
ATOM   1874 O O   . ARG A 1 235 ? -72.869  31.157 13.017  1.00 38.50  ? 1085 ARG A O   1 
ATOM   1875 C CB  . ARG A 1 235 ? -74.786  30.412 14.994  1.00 39.76  ? 1085 ARG A CB  1 
ATOM   1876 C CG  . ARG A 1 235 ? -75.852  30.352 16.075  1.00 52.27  ? 1085 ARG A CG  1 
ATOM   1877 C CD  . ARG A 1 235 ? -75.611  29.249 17.083  1.00 66.63  ? 1085 ARG A CD  1 
ATOM   1878 N NE  . ARG A 1 235 ? -76.710  29.158 18.032  1.00 78.97  ? 1085 ARG A NE  1 
ATOM   1879 C CZ  . ARG A 1 235 ? -77.075  30.123 18.870  1.00 80.60  ? 1085 ARG A CZ  1 
ATOM   1880 N NH1 . ARG A 1 235 ? -76.275  31.149 19.097  1.00 81.08  ? 1085 ARG A NH1 1 
ATOM   1881 N NH2 . ARG A 1 235 ? -78.239  30.053 19.488  1.00 82.05  ? 1085 ARG A NH2 1 
ATOM   1882 N N   . VAL A 1 236 ? -74.235  32.565 11.934  1.00 34.36  ? 1086 VAL A N   1 
ATOM   1883 C CA  . VAL A 1 236 ? -73.342  32.813 10.811  1.00 30.62  ? 1086 VAL A CA  1 
ATOM   1884 C C   . VAL A 1 236 ? -73.332  34.294 10.422  1.00 35.82  ? 1086 VAL A C   1 
ATOM   1885 O O   . VAL A 1 236 ? -74.380  34.934 10.293  1.00 34.29  ? 1086 VAL A O   1 
ATOM   1886 C CB  . VAL A 1 236 ? -73.698  31.911 9.608   1.00 38.34  ? 1086 VAL A CB  1 
ATOM   1887 C CG1 . VAL A 1 236 ? -73.039  32.403 8.375   1.00 42.98  ? 1086 VAL A CG1 1 
ATOM   1888 C CG2 . VAL A 1 236 ? -73.324  30.472 9.879   1.00 42.25  ? 1086 VAL A CG2 1 
ATOM   1889 N N   . THR A 1 237 ? -72.129  34.837 10.230  1.00 32.38  ? 1087 THR A N   1 
ATOM   1890 C CA  . THR A 1 237 ? -71.922  36.142 9.610   1.00 28.94  ? 1087 THR A CA  1 
ATOM   1891 C C   . THR A 1 237 ? -70.977  35.932 8.433   1.00 31.50  ? 1087 THR A C   1 
ATOM   1892 O O   . THR A 1 237 ? -69.922  35.309 8.590   1.00 30.57  ? 1087 THR A O   1 
ATOM   1893 C CB  . THR A 1 237 ? -71.350  37.172 10.602  1.00 30.06  ? 1087 THR A CB  1 
ATOM   1894 O OG1 . THR A 1 237 ? -72.288  37.396 11.662  1.00 32.23  ? 1087 THR A OG1 1 
ATOM   1895 C CG2 . THR A 1 237 ? -71.070  38.503 9.908   1.00 29.80  ? 1087 THR A CG2 1 
ATOM   1896 N N   . VAL A 1 238 ? -71.366  36.407 7.248   1.00 28.04  ? 1088 VAL A N   1 
ATOM   1897 C CA  . VAL A 1 238 ? -70.596  36.165 6.029   1.00 28.22  ? 1088 VAL A CA  1 
ATOM   1898 C C   . VAL A 1 238 ? -70.404  37.474 5.284   1.00 29.16  ? 1088 VAL A C   1 
ATOM   1899 O O   . VAL A 1 238 ? -71.364  38.228 5.079   1.00 28.98  ? 1088 VAL A O   1 
ATOM   1900 C CB  . VAL A 1 238 ? -71.282  35.154 5.084   1.00 32.03  ? 1088 VAL A CB  1 
ATOM   1901 C CG1 . VAL A 1 238 ? -70.356  34.783 3.933   1.00 27.80  ? 1088 VAL A CG1 1 
ATOM   1902 C CG2 . VAL A 1 238 ? -71.709  33.936 5.812   1.00 36.43  ? 1088 VAL A CG2 1 
ATOM   1903 N N   . ALA A 1 239 ? -69.177  37.711 4.818   1.00 23.52  ? 1089 ALA A N   1 
ATOM   1904 C CA  . ALA A 1 239 ? -68.902  38.909 4.032   1.00 25.32  ? 1089 ALA A CA  1 
ATOM   1905 C C   . ALA A 1 239 ? -67.599  38.711 3.277   1.00 31.34  ? 1089 ALA A C   1 
ATOM   1906 O O   . ALA A 1 239 ? -66.617  38.232 3.854   1.00 28.12  ? 1089 ALA A O   1 
ATOM   1907 C CB  . ALA A 1 239 ? -68.824  40.159 4.912   1.00 26.88  ? 1089 ALA A CB  1 
ATOM   1908 N N   . GLY A 1 240 ? -67.601  39.066 1.994   1.00 29.14  ? 1090 GLY A N   1 
ATOM   1909 C CA  . GLY A 1 240 ? -66.418  38.844 1.182   1.00 28.37  ? 1090 GLY A CA  1 
ATOM   1910 C C   . GLY A 1 240 ? -66.027  37.384 1.251   1.00 28.35  ? 1090 GLY A C   1 
ATOM   1911 O O   . GLY A 1 240 ? -66.869  36.486 1.141   1.00 28.92  ? 1090 GLY A O   1 
ATOM   1912 N N   . GLY A 1 241 ? -64.742  37.138 1.485   1.00 28.75  ? 1091 GLY A N   1 
ATOM   1913 C CA  . GLY A 1 241 ? -64.253  35.786 1.656   1.00 27.99  ? 1091 GLY A CA  1 
ATOM   1914 C C   . GLY A 1 241 ? -64.027  35.397 3.104   1.00 29.94  ? 1091 GLY A C   1 
ATOM   1915 O O   . GLY A 1 241 ? -63.091  34.651 3.405   1.00 27.56  ? 1091 GLY A O   1 
ATOM   1916 N N   . VAL A 1 242 ? -64.869  35.898 4.009   1.00 27.72  ? 1092 VAL A N   1 
ATOM   1917 C CA  . VAL A 1 242 ? -64.801  35.564 5.428   1.00 24.23  ? 1092 VAL A CA  1 
ATOM   1918 C C   . VAL A 1 242 ? -66.142  34.984 5.855   1.00 25.28  ? 1092 VAL A C   1 
ATOM   1919 O O   . VAL A 1 242 ? -67.199  35.573 5.581   1.00 26.85  ? 1092 VAL A O   1 
ATOM   1920 C CB  . VAL A 1 242 ? -64.443  36.786 6.296   1.00 25.05  ? 1092 VAL A CB  1 
ATOM   1921 C CG1 . VAL A 1 242 ? -64.286  36.375 7.760   1.00 26.83  ? 1092 VAL A CG1 1 
ATOM   1922 C CG2 . VAL A 1 242 ? -63.179  37.457 5.787   1.00 25.16  ? 1092 VAL A CG2 1 
ATOM   1923 N N   . HIS A 1 243 ? -66.089  33.835 6.530   1.00 27.29  ? 1093 HIS A N   1 
ATOM   1924 C CA  . HIS A 1 243 ? -67.265  33.138 7.040   1.00 28.81  ? 1093 HIS A CA  1 
ATOM   1925 C C   . HIS A 1 243 ? -67.023  32.875 8.519   1.00 29.15  ? 1093 HIS A C   1 
ATOM   1926 O O   . HIS A 1 243 ? -66.066  32.180 8.876   1.00 29.32  ? 1093 HIS A O   1 
ATOM   1927 C CB  . HIS A 1 243 ? -67.504  31.830 6.270   1.00 27.94  ? 1093 HIS A CB  1 
ATOM   1928 C CG  . HIS A 1 243 ? -68.720  31.065 6.706   1.00 34.51  ? 1093 HIS A CG  1 
ATOM   1929 N ND1 . HIS A 1 243 ? -68.755  30.307 7.857   1.00 33.08  ? 1093 HIS A ND1 1 
ATOM   1930 C CD2 . HIS A 1 243 ? -69.935  30.920 6.124   1.00 33.96  ? 1093 HIS A CD2 1 
ATOM   1931 C CE1 . HIS A 1 243 ? -69.942  29.739 7.973   1.00 36.72  ? 1093 HIS A CE1 1 
ATOM   1932 N NE2 . HIS A 1 243 ? -70.677  30.095 6.935   1.00 33.67  ? 1093 HIS A NE2 1 
ATOM   1933 N N   . ILE A 1 244 ? -67.859  33.459 9.375   1.00 29.51  ? 1094 ILE A N   1 
ATOM   1934 C CA  . ILE A 1 244 ? -67.735  33.353 10.825  1.00 27.16  ? 1094 ILE A CA  1 
ATOM   1935 C C   . ILE A 1 244 ? -68.933  32.566 11.333  1.00 31.81  ? 1094 ILE A C   1 
ATOM   1936 O O   . ILE A 1 244 ? -70.084  32.940 11.074  1.00 29.93  ? 1094 ILE A O   1 
ATOM   1937 C CB  . ILE A 1 244 ? -67.661  34.737 11.490  1.00 27.86  ? 1094 ILE A CB  1 
ATOM   1938 C CG1 . ILE A 1 244 ? -66.451  35.518 10.969  1.00 27.69  ? 1094 ILE A CG1 1 
ATOM   1939 C CG2 . ILE A 1 244 ? -67.621  34.604 13.010  1.00 31.44  ? 1094 ILE A CG2 1 
ATOM   1940 C CD1 . ILE A 1 244 ? -66.414  36.965 11.410  1.00 29.06  ? 1094 ILE A CD1 1 
ATOM   1941 N N   . SER A 1 245 ? -68.665  31.475 12.050  1.00 28.07  ? 1095 SER A N   1 
ATOM   1942 C CA  . SER A 1 245 ? -69.681  30.558 12.541  1.00 32.22  ? 1095 SER A CA  1 
ATOM   1943 C C   . SER A 1 245 ? -69.551  30.396 14.046  1.00 38.69  ? 1095 SER A C   1 
ATOM   1944 O O   . SER A 1 245 ? -68.459  30.098 14.554  1.00 31.22  ? 1095 SER A O   1 
ATOM   1945 C CB  . SER A 1 245 ? -69.553  29.186 11.876  1.00 34.53  ? 1095 SER A CB  1 
ATOM   1946 O OG  . SER A 1 245 ? -70.510  28.282 12.401  1.00 39.48  ? 1095 SER A OG  1 
ATOM   1947 N N   . GLY A 1 246 ? -70.670  30.557 14.744  1.00 37.13  ? 1096 GLY A N   1 
ATOM   1948 C CA  . GLY A 1 246 ? -70.728  30.274 16.166  1.00 37.24  ? 1096 GLY A CA  1 
ATOM   1949 C C   . GLY A 1 246 ? -70.062  31.297 17.058  1.00 37.04  ? 1096 GLY A C   1 
ATOM   1950 O O   . GLY A 1 246 ? -69.453  30.926 18.069  1.00 35.07  ? 1096 GLY A O   1 
ATOM   1951 N N   . LEU A 1 247 ? -70.172  32.578 16.714  1.00 32.79  ? 1097 LEU A N   1 
ATOM   1952 C CA  . LEU A 1 247 ? -69.706  33.643 17.592  1.00 29.99  ? 1097 LEU A CA  1 
ATOM   1953 C C   . LEU A 1 247 ? -70.496  33.640 18.893  1.00 42.70  ? 1097 LEU A C   1 
ATOM   1954 O O   . LEU A 1 247 ? -71.729  33.598 18.880  1.00 38.42  ? 1097 LEU A O   1 
ATOM   1955 C CB  . LEU A 1 247 ? -69.866  34.995 16.903  1.00 35.34  ? 1097 LEU A CB  1 
ATOM   1956 C CG  . LEU A 1 247 ? -69.590  36.218 17.782  1.00 37.87  ? 1097 LEU A CG  1 
ATOM   1957 C CD1 . LEU A 1 247 ? -68.136  36.279 18.242  1.00 35.78  ? 1097 LEU A CD1 1 
ATOM   1958 C CD2 . LEU A 1 247 ? -70.018  37.500 17.084  1.00 43.61  ? 1097 LEU A CD2 1 
ATOM   1959 N N   . HIS A 1 248 ? -69.787  33.653 20.019  1.00 33.25  ? 1098 HIS A N   1 
ATOM   1960 C CA  . HIS A 1 248 ? -70.409  33.763 21.332  1.00 35.95  ? 1098 HIS A CA  1 
ATOM   1961 C C   . HIS A 1 248 ? -69.835  34.969 22.060  1.00 41.59  ? 1098 HIS A C   1 
ATOM   1962 O O   . HIS A 1 248 ? -68.614  35.142 22.107  1.00 36.12  ? 1098 HIS A O   1 
ATOM   1963 C CB  . HIS A 1 248 ? -70.194  32.493 22.157  1.00 37.39  ? 1098 HIS A CB  1 
ATOM   1964 C CG  . HIS A 1 248 ? -70.846  32.534 23.503  1.00 49.85  ? 1098 HIS A CG  1 
ATOM   1965 N ND1 . HIS A 1 248 ? -70.143  32.754 24.668  1.00 53.78  ? 1098 HIS A ND1 1 
ATOM   1966 C CD2 . HIS A 1 248 ? -72.142  32.387 23.867  1.00 51.01  ? 1098 HIS A CD2 1 
ATOM   1967 C CE1 . HIS A 1 248 ? -70.978  32.738 25.692  1.00 49.09  ? 1098 HIS A CE1 1 
ATOM   1968 N NE2 . HIS A 1 248 ? -72.196  32.518 25.234  1.00 51.16  ? 1098 HIS A NE2 1 
ATOM   1969 N N   . THR A 1 249 ? -70.706  35.787 22.642  1.00 32.01  ? 1099 THR A N   1 
ATOM   1970 C CA  . THR A 1 249 ? -70.273  36.949 23.402  1.00 35.60  ? 1099 THR A CA  1 
ATOM   1971 C C   . THR A 1 249 ? -70.779  36.846 24.835  1.00 43.60  ? 1099 THR A C   1 
ATOM   1972 O O   . THR A 1 249 ? -71.764  36.163 25.125  1.00 38.57  ? 1099 THR A O   1 
ATOM   1973 C CB  . THR A 1 249 ? -70.772  38.261 22.774  1.00 42.75  ? 1099 THR A CB  1 
ATOM   1974 O OG1 . THR A 1 249 ? -72.206  38.281 22.770  1.00 41.63  ? 1099 THR A OG1 1 
ATOM   1975 C CG2 . THR A 1 249 ? -70.260  38.409 21.344  1.00 41.58  ? 1099 THR A CG2 1 
ATOM   1976 N N   . GLU A 1 250 ? -70.106  37.564 25.726  1.00 40.31  ? 1100 GLU A N   1 
ATOM   1977 C CA  . GLU A 1 250 ? -70.392  37.509 27.152  1.00 42.48  ? 1100 GLU A CA  1 
ATOM   1978 C C   . GLU A 1 250 ? -70.314  38.912 27.725  1.00 46.68  ? 1100 GLU A C   1 
ATOM   1979 O O   . GLU A 1 250 ? -69.620  39.782 27.194  1.00 40.40  ? 1100 GLU A O   1 
ATOM   1980 C CB  . GLU A 1 250 ? -69.445  36.580 27.916  1.00 41.30  ? 1100 GLU A CB  1 
ATOM   1981 C CG  . GLU A 1 250 ? -69.855  35.120 27.881  1.00 45.22  ? 1100 GLU A CG  1 
ATOM   1982 C CD  . GLU A 1 250 ? -68.843  34.217 28.557  1.00 55.12  ? 1100 GLU A CD  1 
ATOM   1983 O OE1 . GLU A 1 250 ? -68.363  34.577 29.654  1.00 56.85  ? 1100 GLU A OE1 1 
ATOM   1984 O OE2 . GLU A 1 250 ? -68.531  33.145 27.998  1.00 53.64  ? 1100 GLU A OE2 1 
ATOM   1985 N N   . SER A 1 251 ? -71.036  39.122 28.822  1.00 45.11  ? 1101 SER A N   1 
ATOM   1986 C CA  . SER A 1 251 ? -71.068  40.439 29.438  1.00 48.74  ? 1101 SER A CA  1 
ATOM   1987 C C   . SER A 1 251 ? -69.681  40.793 29.953  1.00 49.01  ? 1101 SER A C   1 
ATOM   1988 O O   . SER A 1 251 ? -68.992  39.965 30.555  1.00 52.20  ? 1101 SER A O   1 
ATOM   1989 C CB  . SER A 1 251 ? -72.082  40.459 30.583  1.00 49.95  ? 1101 SER A CB  1 
ATOM   1990 O OG  . SER A 1 251 ? -72.547  41.772 30.841  1.00 62.86  ? 1101 SER A OG  1 
ATOM   1991 N N   . ALA A 1 252 ? -69.288  42.042 29.736  1.00 49.12  ? 1102 ALA A N   1 
ATOM   1992 C CA  . ALA A 1 252 ? -67.975  42.511 30.150  1.00 56.30  ? 1102 ALA A CA  1 
ATOM   1993 C C   . ALA A 1 252 ? -68.067  43.870 30.827  1.00 62.44  ? 1102 ALA A C   1 
ATOM   1994 O O   . ALA A 1 252 ? -68.142  44.901 30.162  1.00 65.26  ? 1102 ALA A O   1 
ATOM   1995 C CB  . ALA A 1 252 ? -67.042  42.582 28.948  1.00 59.63  ? 1102 ALA A CB  1 
ATOM   1996 N N   . SER B 1 1   ? -100.436 47.190 60.624  1.00 52.98  ? -7   SER B N   1 
ATOM   1997 C CA  . SER B 1 1   ? -99.837  47.985 59.559  1.00 51.16  ? -7   SER B CA  1 
ATOM   1998 C C   . SER B 1 1   ? -98.446  48.449 59.953  1.00 53.30  ? -7   SER B C   1 
ATOM   1999 O O   . SER B 1 1   ? -98.190  48.711 61.120  1.00 51.03  ? -7   SER B O   1 
ATOM   2000 C CB  . SER B 1 1   ? -100.733 49.185 59.231  1.00 48.29  ? -7   SER B CB  1 
ATOM   2001 O OG  . SER B 1 1   ? -100.820 50.078 60.329  1.00 49.47  ? -7   SER B OG  1 
ATOM   2002 N N   . GLU B 1 2   ? -97.589  48.598 58.929  1.00 45.58  ? -6   GLU B N   1 
ATOM   2003 C CA  . GLU B 1 2   ? -96.259  49.221 59.130  1.00 46.59  ? -6   GLU B CA  1 
ATOM   2004 C C   . GLU B 1 2   ? -96.467  50.714 58.855  1.00 41.90  ? -6   GLU B C   1 
ATOM   2005 O O   . GLU B 1 2   ? -97.007  51.023 57.800  1.00 40.36  ? -6   GLU B O   1 
ATOM   2006 C CB  . GLU B 1 2   ? -95.189  48.617 58.221  1.00 49.35  ? -6   GLU B CB  1 
ATOM   2007 C CG  . GLU B 1 2   ? -93.953  49.485 58.115  1.00 52.75  ? -6   GLU B CG  1 
ATOM   2008 C CD  . GLU B 1 2   ? -92.987  49.161 56.988  1.00 58.95  ? -6   GLU B CD  1 
ATOM   2009 O OE1 . GLU B 1 2   ? -93.378  49.274 55.815  1.00 55.87  ? -6   GLU B OE1 1 
ATOM   2010 O OE2 . GLU B 1 2   ? -91.838  48.808 57.292  1.00 66.69  ? -6   GLU B OE2 1 
ATOM   2011 N N   . ASN B 1 3   ? -96.104  51.577 59.791  1.00 34.99  ? -5   ASN B N   1 
ATOM   2012 C CA  . ASN B 1 3   ? -96.376  53.003 59.676  1.00 34.55  ? -5   ASN B CA  1 
ATOM   2013 C C   . ASN B 1 3   ? -95.082  53.783 59.489  1.00 35.20  ? -5   ASN B C   1 
ATOM   2014 O O   . ASN B 1 3   ? -94.144  53.640 60.280  1.00 36.27  ? -5   ASN B O   1 
ATOM   2015 C CB  . ASN B 1 3   ? -97.105  53.515 60.918  1.00 31.40  ? -5   ASN B CB  1 
ATOM   2016 C CG  . ASN B 1 3   ? -98.359  52.726 61.222  1.00 35.11  ? -5   ASN B CG  1 
ATOM   2017 O OD1 . ASN B 1 3   ? -98.810  51.916 60.412  1.00 34.47  ? -5   ASN B OD1 1 
ATOM   2018 N ND2 . ASN B 1 3   ? -98.921  52.946 62.403  1.00 35.10  ? -5   ASN B ND2 1 
ATOM   2019 N N   . LEU B 1 4   ? -95.074  54.667 58.494  1.00 29.77  ? -4   LEU B N   1 
ATOM   2020 C CA  . LEU B 1 4   ? -93.929  55.503 58.160  1.00 28.95  ? -4   LEU B CA  1 
ATOM   2021 C C   . LEU B 1 4   ? -94.345  56.956 58.329  1.00 29.75  ? -4   LEU B C   1 
ATOM   2022 O O   . LEU B 1 4   ? -95.374  57.367 57.787  1.00 26.57  ? -4   LEU B O   1 
ATOM   2023 C CB  . LEU B 1 4   ? -93.485  55.252 56.717  1.00 28.60  ? -4   LEU B CB  1 
ATOM   2024 C CG  . LEU B 1 4   ? -93.271  53.784 56.349  1.00 35.27  ? -4   LEU B CG  1 
ATOM   2025 C CD1 . LEU B 1 4   ? -93.031  53.629 54.858  1.00 35.99  ? -4   LEU B CD1 1 
ATOM   2026 C CD2 . LEU B 1 4   ? -92.110  53.216 57.141  1.00 39.71  ? -4   LEU B CD2 1 
ATOM   2027 N N   . TYR B 1 5   ? -93.566  57.734 59.079  1.00 27.70  ? -3   TYR B N   1 
ATOM   2028 C CA  . TYR B 1 5   ? -93.954  59.100 59.406  1.00 23.48  ? -3   TYR B CA  1 
ATOM   2029 C C   . TYR B 1 5   ? -93.016  60.116 58.767  1.00 30.12  ? -3   TYR B C   1 
ATOM   2030 O O   . TYR B 1 5   ? -91.811  59.882 58.637  1.00 28.00  ? -3   TYR B O   1 
ATOM   2031 C CB  . TYR B 1 5   ? -93.994  59.312 60.920  1.00 27.96  ? -3   TYR B CB  1 
ATOM   2032 C CG  . TYR B 1 5   ? -94.986  58.401 61.586  1.00 31.90  ? -3   TYR B CG  1 
ATOM   2033 C CD1 . TYR B 1 5   ? -96.349  58.581 61.397  1.00 30.18  ? -3   TYR B CD1 1 
ATOM   2034 C CD2 . TYR B 1 5   ? -94.566  57.344 62.381  1.00 33.45  ? -3   TYR B CD2 1 
ATOM   2035 C CE1 . TYR B 1 5   ? -97.268  57.743 61.991  1.00 28.87  ? -3   TYR B CE1 1 
ATOM   2036 C CE2 . TYR B 1 5   ? -95.478  56.500 62.981  1.00 35.99  ? -3   TYR B CE2 1 
ATOM   2037 C CZ  . TYR B 1 5   ? -96.828  56.704 62.782  1.00 37.45  ? -3   TYR B CZ  1 
ATOM   2038 O OH  . TYR B 1 5   ? -97.743  55.866 63.376  1.00 37.54  ? -3   TYR B OH  1 
ATOM   2039 N N   . PHE B 1 6   ? -93.582  61.267 58.398  1.00 26.68  ? -2   PHE B N   1 
ATOM   2040 C CA  . PHE B 1 6   ? -92.858  62.309 57.681  1.00 23.01  ? -2   PHE B CA  1 
ATOM   2041 C C   . PHE B 1 6   ? -93.134  63.664 58.311  1.00 30.88  ? -2   PHE B C   1 
ATOM   2042 O O   . PHE B 1 6   ? -94.291  64.009 58.576  1.00 27.10  ? -2   PHE B O   1 
ATOM   2043 C CB  . PHE B 1 6   ? -93.238  62.313 56.197  1.00 24.54  ? -2   PHE B CB  1 
ATOM   2044 C CG  . PHE B 1 6   ? -93.046  60.985 55.540  1.00 24.77  ? -2   PHE B CG  1 
ATOM   2045 C CD1 . PHE B 1 6   ? -91.807  60.621 55.043  1.00 25.84  ? -2   PHE B CD1 1 
ATOM   2046 C CD2 . PHE B 1 6   ? -94.091  60.083 55.455  1.00 25.50  ? -2   PHE B CD2 1 
ATOM   2047 C CE1 . PHE B 1 6   ? -91.618  59.388 54.454  1.00 27.07  ? -2   PHE B CE1 1 
ATOM   2048 C CE2 . PHE B 1 6   ? -93.909  58.848 54.868  1.00 27.91  ? -2   PHE B CE2 1 
ATOM   2049 C CZ  . PHE B 1 6   ? -92.670  58.500 54.366  1.00 29.15  ? -2   PHE B CZ  1 
ATOM   2050 N N   . GLN B 1 7   ? -92.065  64.426 58.557  1.00 26.20  ? -1   GLN B N   1 
ATOM   2051 C CA  . GLN B 1 7   ? -92.194  65.721 59.216  1.00 26.55  ? -1   GLN B CA  1 
ATOM   2052 C C   . GLN B 1 7   ? -92.755  66.794 58.295  1.00 27.85  ? -1   GLN B C   1 
ATOM   2053 O O   . GLN B 1 7   ? -93.238  67.821 58.786  1.00 31.60  ? -1   GLN B O   1 
ATOM   2054 C CB  . GLN B 1 7   ? -90.842  66.194 59.757  1.00 30.91  ? -1   GLN B CB  1 
ATOM   2055 C CG  . GLN B 1 7   ? -89.709  66.237 58.738  1.00 28.38  ? -1   GLN B CG  1 
ATOM   2056 C CD  . GLN B 1 7   ? -88.449  66.858 59.317  1.00 35.45  ? -1   GLN B CD  1 
ATOM   2057 O OE1 . GLN B 1 7   ? -88.442  68.031 59.692  1.00 36.80  ? -1   GLN B OE1 1 
ATOM   2058 N NE2 . GLN B 1 7   ? -87.383  66.072 59.404  1.00 29.19  ? -1   GLN B NE2 1 
ATOM   2059 N N   . SER B 1 8   ? -92.715  66.575 56.984  1.00 26.40  ? 858  SER B N   1 
ATOM   2060 C CA  A SER B 1 8   ? -93.143  67.561 56.003  0.64 29.37  ? 858  SER B CA  1 
ATOM   2061 C CA  B SER B 1 8   ? -93.043  67.561 56.003  0.36 29.45  ? 858  SER B CA  1 
ATOM   2062 C C   . SER B 1 8   ? -93.283  66.872 54.657  1.00 26.83  ? 858  SER B C   1 
ATOM   2063 O O   . SER B 1 8   ? -92.653  65.841 54.403  1.00 25.46  ? 858  SER B O   1 
ATOM   2064 C CB  A SER B 1 8   ? -92.112  68.691 55.896  0.64 30.42  ? 858  SER B CB  1 
ATOM   2065 C CB  B SER B 1 8   ? -92.012  68.691 55.896  0.36 30.37  ? 858  SER B CB  1 
ATOM   2066 O OG  A SER B 1 8   ? -92.643  69.867 55.325  0.64 40.03  ? 858  SER B OG  1 
ATOM   2067 O OG  B SER B 1 8   ? -90.748  68.242 55.460  0.36 34.08  ? 858  SER B OG  1 
ATOM   2068 N N   . ALA B 1 9   ? -94.080  67.476 53.781  1.00 27.34  ? 859  ALA B N   1 
ATOM   2069 C CA  . ALA B 1 9   ? -94.169  66.988 52.413  1.00 23.92  ? 859  ALA B CA  1 
ATOM   2070 C C   . ALA B 1 9   ? -94.606  68.133 51.514  1.00 24.47  ? 859  ALA B C   1 
ATOM   2071 O O   . ALA B 1 9   ? -95.139  69.145 51.974  1.00 26.51  ? 859  ALA B O   1 
ATOM   2072 C CB  . ALA B 1 9   ? -95.121  65.792 52.292  1.00 24.26  ? 859  ALA B CB  1 
ATOM   2073 N N   . ALA B 1 10  ? -94.374  67.949 50.219  1.00 24.09  ? 860  ALA B N   1 
ATOM   2074 C CA  . ALA B 1 10  ? -94.750  68.936 49.220  1.00 22.31  ? 860  ALA B CA  1 
ATOM   2075 C C   . ALA B 1 10  ? -94.951  68.226 47.894  1.00 27.86  ? 860  ALA B C   1 
ATOM   2076 O O   . ALA B 1 10  ? -94.284  67.236 47.603  1.00 25.76  ? 860  ALA B O   1 
ATOM   2077 C CB  . ALA B 1 10  ? -93.690  70.036 49.079  1.00 26.12  ? 860  ALA B CB  1 
ATOM   2078 N N   . ILE B 1 11  ? -95.879  68.725 47.089  1.00 26.10  ? 861  ILE B N   1 
ATOM   2079 C CA  . ILE B 1 11  ? -96.134  68.164 45.770  1.00 26.48  ? 861  ILE B CA  1 
ATOM   2080 C C   . ILE B 1 11  ? -95.891  69.260 44.744  1.00 26.46  ? 861  ILE B C   1 
ATOM   2081 O O   . ILE B 1 11  ? -96.386  70.382 44.896  1.00 28.58  ? 861  ILE B O   1 
ATOM   2082 C CB  . ILE B 1 11  ? -97.555  67.579 45.658  1.00 28.49  ? 861  ILE B CB  1 
ATOM   2083 C CG1 . ILE B 1 11  ? -97.647  66.278 46.468  1.00 25.96  ? 861  ILE B CG1 1 
ATOM   2084 C CG2 . ILE B 1 11  ? -97.917  67.328 44.200  1.00 30.62  ? 861  ILE B CG2 1 
ATOM   2085 C CD1 . ILE B 1 11  ? -99.056  65.717 46.625  1.00 28.34  ? 861  ILE B CD1 1 
ATOM   2086 N N   . TYR B 1 12  ? -95.100  68.941 43.724  1.00 24.88  ? 862  TYR B N   1 
ATOM   2087 C CA  . TYR B 1 12  ? -94.723  69.871 42.670  1.00 28.17  ? 862  TYR B CA  1 
ATOM   2088 C C   . TYR B 1 12  ? -95.386  69.383 41.392  1.00 29.51  ? 862  TYR B C   1 
ATOM   2089 O O   . TYR B 1 12  ? -95.024  68.326 40.859  1.00 26.32  ? 862  TYR B O   1 
ATOM   2090 C CB  . TYR B 1 12  ? -93.203  69.948 42.544  1.00 27.36  ? 862  TYR B CB  1 
ATOM   2091 C CG  . TYR B 1 12  ? -92.603  70.476 43.819  1.00 29.29  ? 862  TYR B CG  1 
ATOM   2092 C CD1 . TYR B 1 12  ? -92.288  69.618 44.865  1.00 26.35  ? 862  TYR B CD1 1 
ATOM   2093 C CD2 . TYR B 1 12  ? -92.432  71.837 44.014  1.00 29.28  ? 862  TYR B CD2 1 
ATOM   2094 C CE1 . TYR B 1 12  ? -91.774  70.099 46.050  1.00 24.53  ? 862  TYR B CE1 1 
ATOM   2095 C CE2 . TYR B 1 12  ? -91.921  72.328 45.196  1.00 29.73  ? 862  TYR B CE2 1 
ATOM   2096 C CZ  . TYR B 1 12  ? -91.594  71.455 46.211  1.00 28.31  ? 862  TYR B CZ  1 
ATOM   2097 O OH  . TYR B 1 12  ? -91.084  71.941 47.392  1.00 28.20  ? 862  TYR B OH  1 
ATOM   2098 N N   . ASN B 1 13  ? -96.392  70.125 40.942  1.00 30.51  ? 863  ASN B N   1 
ATOM   2099 C CA  . ASN B 1 13  ? -97.119  69.790 39.727  1.00 29.45  ? 863  ASN B CA  1 
ATOM   2100 C C   . ASN B 1 13  ? -96.466  70.561 38.583  1.00 32.25  ? 863  ASN B C   1 
ATOM   2101 O O   . ASN B 1 13  ? -96.618  71.782 38.478  1.00 35.82  ? 863  ASN B O   1 
ATOM   2102 C CB  . ASN B 1 13  ? -98.600  70.126 39.894  1.00 31.83  ? 863  ASN B CB  1 
ATOM   2103 C CG  . ASN B 1 13  ? -99.326  69.125 40.791  1.00 34.14  ? 863  ASN B CG  1 
ATOM   2104 O OD1 . ASN B 1 13  ? -99.069  67.925 40.734  1.00 32.97  ? 863  ASN B OD1 1 
ATOM   2105 N ND2 . ASN B 1 13  ? -100.219 69.624 41.640  1.00 37.32  ? 863  ASN B ND2 1 
ATOM   2106 N N   . ILE B 1 14  ? -95.733  69.844 37.734  1.00 33.26  ? 864  ILE B N   1 
ATOM   2107 C CA  . ILE B 1 14  ? -94.870  70.424 36.716  1.00 37.13  ? 864  ILE B CA  1 
ATOM   2108 C C   . ILE B 1 14  ? -95.565  70.325 35.370  1.00 31.46  ? 864  ILE B C   1 
ATOM   2109 O O   . ILE B 1 14  ? -95.995  69.239 34.961  1.00 37.85  ? 864  ILE B O   1 
ATOM   2110 C CB  . ILE B 1 14  ? -93.507  69.714 36.658  1.00 39.59  ? 864  ILE B CB  1 
ATOM   2111 C CG1 . ILE B 1 14  ? -93.012  69.342 38.061  1.00 40.93  ? 864  ILE B CG1 1 
ATOM   2112 C CG2 . ILE B 1 14  ? -92.508  70.575 35.891  1.00 41.58  ? 864  ILE B CG2 1 
ATOM   2113 C CD1 . ILE B 1 14  ? -91.818  70.136 38.544  1.00 37.70  ? 864  ILE B CD1 1 
ATOM   2114 N N   . ASP B 1 15  ? -95.648  71.454 34.677  1.00 35.05  ? 865  ASP B N   1 
ATOM   2115 C CA  . ASP B 1 15  ? -96.235  71.562 33.351  1.00 37.17  ? 865  ASP B CA  1 
ATOM   2116 C C   . ASP B 1 15  ? -95.162  72.131 32.434  1.00 32.24  ? 865  ASP B C   1 
ATOM   2117 O O   . ASP B 1 15  ? -94.560  73.157 32.757  1.00 37.81  ? 865  ASP B O   1 
ATOM   2118 C CB  . ASP B 1 15  ? -97.467  72.478 33.406  1.00 36.31  ? 865  ASP B CB  1 
ATOM   2119 C CG  . ASP B 1 15  ? -98.193  72.596 32.079  1.00 46.52  ? 865  ASP B CG  1 
ATOM   2120 O OD1 . ASP B 1 15  ? -97.703  72.073 31.058  1.00 38.73  ? 865  ASP B OD1 1 
ATOM   2121 O OD2 . ASP B 1 15  ? -99.267  73.234 32.064  1.00 55.46  ? 865  ASP B OD2 1 
ATOM   2122 N N   . THR B 1 16  ? -94.876  71.452 31.323  1.00 36.17  ? 866  THR B N   1 
ATOM   2123 C CA  . THR B 1 16  ? -93.839  71.930 30.416  1.00 36.28  ? 866  THR B CA  1 
ATOM   2124 C C   . THR B 1 16  ? -94.406  72.620 29.186  1.00 35.10  ? 866  THR B C   1 
ATOM   2125 O O   . THR B 1 16  ? -93.650  72.940 28.263  1.00 36.48  ? 866  THR B O   1 
ATOM   2126 C CB  . THR B 1 16  ? -92.911  70.791 29.988  1.00 34.67  ? 866  THR B CB  1 
ATOM   2127 O OG1 . THR B 1 16  ? -93.654  69.792 29.276  1.00 34.15  ? 866  THR B OG1 1 
ATOM   2128 C CG2 . THR B 1 16  ? -92.235  70.183 31.197  1.00 37.72  ? 866  THR B CG2 1 
ATOM   2129 N N   . SER B 1 17  ? -95.706  72.900 29.179  1.00 37.56  ? 867  SER B N   1 
ATOM   2130 C CA  . SER B 1 17  ? -96.318  73.623 28.078  1.00 42.57  ? 867  SER B CA  1 
ATOM   2131 C C   . SER B 1 17  ? -95.705  75.015 27.959  1.00 37.46  ? 867  SER B C   1 
ATOM   2132 O O   . SER B 1 17  ? -95.064  75.523 28.881  1.00 34.12  ? 867  SER B O   1 
ATOM   2133 C CB  . SER B 1 17  ? -97.827  73.727 28.294  1.00 43.73  ? 867  SER B CB  1 
ATOM   2134 O OG  . SER B 1 17  ? -98.155  74.961 28.910  1.00 43.41  ? 867  SER B OG  1 
ATOM   2135 N N   . SER B 1 18  ? -95.906  75.633 26.796  1.00 39.14  ? 868  SER B N   1 
ATOM   2136 C CA  . SER B 1 18  ? -95.262  76.912 26.520  1.00 31.49  ? 868  SER B CA  1 
ATOM   2137 C C   . SER B 1 18  ? -95.734  78.012 27.466  1.00 35.06  ? 868  SER B C   1 
ATOM   2138 O O   . SER B 1 18  ? -95.077  79.053 27.560  1.00 37.21  ? 868  SER B O   1 
ATOM   2139 C CB  . SER B 1 18  ? -95.479  77.315 25.060  1.00 42.23  ? 868  SER B CB  1 
ATOM   2140 O OG  . SER B 1 18  ? -96.852  77.464 24.765  1.00 46.62  ? 868  SER B OG  1 
ATOM   2141 N N   . GLU B 1 19  ? -96.923  77.871 28.051  1.00 36.34  ? 869  GLU B N   1 
ATOM   2142 C CA  . GLU B 1 19  ? -97.445  78.863 28.987  1.00 38.29  ? 869  GLU B CA  1 
ATOM   2143 C C   . GLU B 1 19  ? -96.793  78.783 30.376  1.00 41.73  ? 869  GLU B C   1 
ATOM   2144 O O   . GLU B 1 19  ? -96.948  79.714 31.178  1.00 40.65  ? 869  GLU B O   1 
ATOM   2145 C CB  . GLU B 1 19  ? -98.974  78.761 29.006  1.00 42.24  ? 869  GLU B CB  1 
ATOM   2146 C CG  . GLU B 1 19  ? -99.689  79.440 30.141  1.00 47.37  ? 869  GLU B CG  1 
ATOM   2147 C CD  . GLU B 1 19  ? -101.100 79.819 29.744  1.00 53.04  ? 869  GLU B CD  1 
ATOM   2148 O OE1 . GLU B 1 19  ? -101.770 79.017 29.067  1.00 53.98  ? 869  GLU B OE1 1 
ATOM   2149 O OE2 . GLU B 1 19  ? -101.540 80.926 30.103  1.00 55.74  ? 869  GLU B OE2 1 
ATOM   2150 N N   . SER B 1 20  ? -96.207  77.635 30.732  1.00 39.03  ? 870  SER B N   1 
ATOM   2151 C CA  . SER B 1 20  ? -95.670  77.345 32.055  1.00 36.92  ? 870  SER B CA  1 
ATOM   2152 C C   . SER B 1 20  ? -94.262  77.916 32.262  1.00 37.26  ? 870  SER B C   1 
ATOM   2153 O O   . SER B 1 20  ? -93.437  77.914 31.342  1.00 33.54  ? 870  SER B O   1 
ATOM   2154 C CB  . SER B 1 20  ? -95.640  75.845 32.285  1.00 39.42  ? 870  SER B CB  1 
ATOM   2155 O OG  . SER B 1 20  ? -94.965  75.522 33.489  1.00 38.43  ? 870  SER B OG  1 
ATOM   2156 N N   . PRO B 1 21  ? -93.952  78.337 33.492  1.00 38.74  ? 871  PRO B N   1 
ATOM   2157 C CA  . PRO B 1 21  ? -92.573  78.734 33.827  1.00 36.87  ? 871  PRO B CA  1 
ATOM   2158 C C   . PRO B 1 21  ? -91.577  77.604 33.698  1.00 31.68  ? 871  PRO B C   1 
ATOM   2159 O O   . PRO B 1 21  ? -90.366  77.855 33.661  1.00 38.21  ? 871  PRO B O   1 
ATOM   2160 C CB  . PRO B 1 21  ? -92.689  79.185 35.291  1.00 38.69  ? 871  PRO B CB  1 
ATOM   2161 C CG  . PRO B 1 21  ? -94.143  79.487 35.490  1.00 48.00  ? 871  PRO B CG  1 
ATOM   2162 C CD  . PRO B 1 21  ? -94.869  78.507 34.629  1.00 38.91  ? 871  PRO B CD  1 
ATOM   2163 N N   . ASP B 1 22  ? -92.050  76.368 33.616  1.00 31.18  ? 872  ASP B N   1 
ATOM   2164 C CA  . ASP B 1 22  ? -91.194  75.199 33.536  1.00 33.57  ? 872  ASP B CA  1 
ATOM   2165 C C   . ASP B 1 22  ? -91.056  74.681 32.114  1.00 31.65  ? 872  ASP B C   1 
ATOM   2166 O O   . ASP B 1 22  ? -90.577  73.560 31.915  1.00 29.65  ? 872  ASP B O   1 
ATOM   2167 C CB  . ASP B 1 22  ? -91.744  74.129 34.472  1.00 31.69  ? 872  ASP B CB  1 
ATOM   2168 C CG  . ASP B 1 22  ? -91.689  74.568 35.920  1.00 37.73  ? 872  ASP B CG  1 
ATOM   2169 O OD1 . ASP B 1 22  ? -90.647  75.125 36.325  1.00 40.32  ? 872  ASP B OD1 1 
ATOM   2170 O OD2 . ASP B 1 22  ? -92.704  74.427 36.632  1.00 41.83  ? 872  ASP B OD2 1 
ATOM   2171 N N   . HIS B 1 23  ? -91.444  75.489 31.122  1.00 30.75  ? 873  HIS B N   1 
ATOM   2172 C CA  . HIS B 1 23  ? -91.268  75.103 29.727  1.00 33.00  ? 873  HIS B CA  1 
ATOM   2173 C C   . HIS B 1 23  ? -89.817  74.764 29.410  1.00 31.25  ? 873  HIS B C   1 
ATOM   2174 O O   . HIS B 1 23  ? -89.556  73.904 28.559  1.00 33.12  ? 873  HIS B O   1 
ATOM   2175 C CB  . HIS B 1 23  ? -91.750  76.215 28.796  1.00 30.51  ? 873  HIS B CB  1 
ATOM   2176 C CG  . HIS B 1 23  ? -91.661  75.855 27.347  1.00 29.66  ? 873  HIS B CG  1 
ATOM   2177 N ND1 . HIS B 1 23  ? -92.246  74.721 26.828  1.00 36.00  ? 873  HIS B ND1 1 
ATOM   2178 C CD2 . HIS B 1 23  ? -91.007  76.445 26.319  1.00 35.19  ? 873  HIS B CD2 1 
ATOM   2179 C CE1 . HIS B 1 23  ? -91.984  74.645 25.536  1.00 35.46  ? 873  HIS B CE1 1 
ATOM   2180 N NE2 . HIS B 1 23  ? -91.231  75.678 25.202  1.00 36.50  ? 873  HIS B NE2 1 
ATOM   2181 N N   . TYR B 1 24  ? -88.863  75.421 30.082  1.00 30.25  ? 874  TYR B N   1 
ATOM   2182 C CA  . TYR B 1 24  ? -87.447  75.190 29.805  1.00 30.66  ? 874  TYR B CA  1 
ATOM   2183 C C   . TYR B 1 24  ? -87.075  73.710 29.862  1.00 30.78  ? 874  TYR B C   1 
ATOM   2184 O O   . TYR B 1 24  ? -86.116  73.287 29.200  1.00 29.67  ? 874  TYR B O   1 
ATOM   2185 C CB  . TYR B 1 24  ? -86.584  75.995 30.791  1.00 31.08  ? 874  TYR B CB  1 
ATOM   2186 C CG  . TYR B 1 24  ? -86.487  75.398 32.185  1.00 31.31  ? 874  TYR B CG  1 
ATOM   2187 C CD1 . TYR B 1 24  ? -87.510  75.566 33.112  1.00 28.03  ? 874  TYR B CD1 1 
ATOM   2188 C CD2 . TYR B 1 24  ? -85.376  74.654 32.566  1.00 31.58  ? 874  TYR B CD2 1 
ATOM   2189 C CE1 . TYR B 1 24  ? -87.422  75.016 34.386  1.00 31.35  ? 874  TYR B CE1 1 
ATOM   2190 C CE2 . TYR B 1 24  ? -85.282  74.099 33.833  1.00 32.26  ? 874  TYR B CE2 1 
ATOM   2191 C CZ  . TYR B 1 24  ? -86.306  74.282 34.738  1.00 32.32  ? 874  TYR B CZ  1 
ATOM   2192 O OH  . TYR B 1 24  ? -86.213  73.731 35.999  1.00 30.60  ? 874  TYR B OH  1 
ATOM   2193 N N   . LEU B 1 25  ? -87.839  72.910 30.611  1.00 28.76  ? 875  LEU B N   1 
ATOM   2194 C CA  . LEU B 1 25  ? -87.542  71.491 30.771  1.00 30.13  ? 875  LEU B CA  1 
ATOM   2195 C C   . LEU B 1 25  ? -87.636  70.708 29.468  1.00 32.74  ? 875  LEU B C   1 
ATOM   2196 O O   . LEU B 1 25  ? -87.067  69.614 29.381  1.00 31.04  ? 875  LEU B O   1 
ATOM   2197 C CB  . LEU B 1 25  ? -88.480  70.878 31.808  1.00 29.30  ? 875  LEU B CB  1 
ATOM   2198 C CG  . LEU B 1 25  ? -88.240  71.340 33.245  1.00 30.17  ? 875  LEU B CG  1 
ATOM   2199 C CD1 . LEU B 1 25  ? -89.336  70.826 34.165  1.00 27.33  ? 875  LEU B CD1 1 
ATOM   2200 C CD2 . LEU B 1 25  ? -86.867  70.899 33.732  1.00 31.56  ? 875  LEU B CD2 1 
ATOM   2201 N N   . VAL B 1 26  ? -88.356  71.213 28.462  1.00 32.97  ? 876  VAL B N   1 
ATOM   2202 C CA  . VAL B 1 26  ? -88.411  70.484 27.200  1.00 32.63  ? 876  VAL B CA  1 
ATOM   2203 C C   . VAL B 1 26  ? -87.056  70.438 26.519  1.00 31.71  ? 876  VAL B C   1 
ATOM   2204 O O   . VAL B 1 26  ? -86.864  69.641 25.592  1.00 35.66  ? 876  VAL B O   1 
ATOM   2205 C CB  . VAL B 1 26  ? -89.459  71.077 26.237  1.00 33.77  ? 876  VAL B CB  1 
ATOM   2206 C CG1 . VAL B 1 26  ? -90.825  71.122 26.905  1.00 32.73  ? 876  VAL B CG1 1 
ATOM   2207 C CG2 . VAL B 1 26  ? -89.029  72.452 25.760  1.00 35.02  ? 876  VAL B CG2 1 
ATOM   2208 N N   . ASP B 1 27  ? -86.100  71.254 26.965  1.00 30.41  ? 877  ASP B N   1 
ATOM   2209 C CA  . ASP B 1 27  ? -84.786  71.249 26.343  1.00 29.56  ? 877  ASP B CA  1 
ATOM   2210 C C   . ASP B 1 27  ? -83.825  70.264 27.000  1.00 33.51  ? 877  ASP B C   1 
ATOM   2211 O O   . ASP B 1 27  ? -82.641  70.248 26.651  1.00 31.60  ? 877  ASP B O   1 
ATOM   2212 C CB  . ASP B 1 27  ? -84.188  72.657 26.355  1.00 29.58  ? 877  ASP B CB  1 
ATOM   2213 C CG  . ASP B 1 27  ? -84.774  73.548 25.273  1.00 35.16  ? 877  ASP B CG  1 
ATOM   2214 O OD1 . ASP B 1 27  ? -85.499  73.025 24.400  1.00 36.34  ? 877  ASP B OD1 1 
ATOM   2215 O OD2 . ASP B 1 27  ? -84.501  74.766 25.288  1.00 35.22  ? 877  ASP B OD2 1 
ATOM   2216 N N   . HIS B 1 28  ? -84.308  69.408 27.894  1.00 31.86  ? 878  HIS B N   1 
ATOM   2217 C CA  . HIS B 1 28  ? -83.477  68.380 28.517  1.00 32.59  ? 878  HIS B CA  1 
ATOM   2218 C C   . HIS B 1 28  ? -84.002  67.039 28.011  1.00 33.07  ? 878  HIS B C   1 
ATOM   2219 O O   . HIS B 1 28  ? -84.899  66.441 28.610  1.00 34.62  ? 878  HIS B O   1 
ATOM   2220 C CB  . HIS B 1 28  ? -83.490  68.485 30.053  1.00 29.39  ? 878  HIS B CB  1 
ATOM   2221 C CG  . HIS B 1 28  ? -82.563  67.525 30.739  1.00 28.96  ? 878  HIS B CG  1 
ATOM   2222 N ND1 . HIS B 1 28  ? -82.942  66.248 31.094  1.00 30.86  ? 878  HIS B ND1 1 
ATOM   2223 C CD2 . HIS B 1 28  ? -81.267  67.650 31.115  1.00 29.54  ? 878  HIS B CD2 1 
ATOM   2224 C CE1 . HIS B 1 28  ? -81.926  65.634 31.674  1.00 29.18  ? 878  HIS B CE1 1 
ATOM   2225 N NE2 . HIS B 1 28  ? -80.897  66.461 31.696  1.00 28.67  ? 878  HIS B NE2 1 
ATOM   2226 N N   . THR B 1 29  ? -83.495  66.619 26.844  1.00 35.68  ? 879  THR B N   1 
ATOM   2227 C CA  . THR B 1 29  ? -83.907  65.397 26.174  1.00 41.96  ? 879  THR B CA  1 
ATOM   2228 C C   . THR B 1 29  ? -82.688  64.480 26.094  1.00 37.67  ? 879  THR B C   1 
ATOM   2229 O O   . THR B 1 29  ? -81.622  64.908 25.649  1.00 48.41  ? 879  THR B O   1 
ATOM   2230 C CB  . THR B 1 29  ? -84.434  65.746 24.770  1.00 40.20  ? 879  THR B CB  1 
ATOM   2231 O OG1 . THR B 1 29  ? -85.699  66.417 24.870  1.00 44.84  ? 879  THR B OG1 1 
ATOM   2232 C CG2 . THR B 1 29  ? -84.567  64.519 23.894  1.00 49.69  ? 879  THR B CG2 1 
ATOM   2233 N N   . LEU B 1 30  ? -82.895  63.224 26.431  1.00 43.26  ? 880  LEU B N   1 
ATOM   2234 C CA  . LEU B 1 30  ? -81.815  62.203 26.357  1.00 54.80  ? 880  LEU B CA  1 
ATOM   2235 C C   . LEU B 1 30  ? -82.388  60.960 25.663  1.00 54.44  ? 880  LEU B C   1 
ATOM   2236 O O   . LEU B 1 30  ? -83.485  60.565 26.046  1.00 54.81  ? 880  LEU B O   1 
ATOM   2237 C CB  . LEU B 1 30  ? -81.294  61.880 27.768  1.00 53.76  ? 880  LEU B CB  1 
ATOM   2238 C CG  . LEU B 1 30  ? -80.423  62.942 28.441  1.00 51.70  ? 880  LEU B CG  1 
ATOM   2239 C CD1 . LEU B 1 30  ? -79.462  62.315 29.435  1.00 55.40  ? 880  LEU B CD1 1 
ATOM   2240 C CD2 . LEU B 1 30  ? -79.652  63.753 27.421  1.00 57.12  ? 880  LEU B CD2 1 
ATOM   2241 N N   . ASP B 1 31  ? -81.688  60.421 24.655  1.00 60.60  ? 881  ASP B N   1 
ATOM   2242 C CA  . ASP B 1 31  ? -82.125  59.232 23.855  1.00 60.82  ? 881  ASP B CA  1 
ATOM   2243 C C   . ASP B 1 31  ? -83.508  59.462 23.246  1.00 57.85  ? 881  ASP B C   1 
ATOM   2244 O O   . ASP B 1 31  ? -84.234  58.478 23.063  1.00 63.96  ? 881  ASP B O   1 
ATOM   2245 C CB  . ASP B 1 31  ? -82.008  57.911 24.619  1.00 64.37  ? 881  ASP B CB  1 
ATOM   2246 C CG  . ASP B 1 31  ? -81.767  56.710 23.724  1.00 57.32  ? 881  ASP B CG  1 
ATOM   2247 O OD1 . ASP B 1 31  ? -81.573  56.912 22.522  1.00 57.57  ? 881  ASP B OD1 1 
ATOM   2248 O OD2 . ASP B 1 31  ? -81.795  55.589 24.241  1.00 68.27  ? 881  ASP B OD2 1 
ATOM   2249 N N   . GLY B 1 32  ? -83.849  60.711 22.972  1.00 53.04  ? 882  GLY B N   1 
ATOM   2250 C CA  . GLY B 1 32  ? -85.093  61.000 22.246  1.00 59.15  ? 882  GLY B CA  1 
ATOM   2251 C C   . GLY B 1 32  ? -86.219  61.299 23.187  1.00 61.76  ? 882  GLY B C   1 
ATOM   2252 O O   . GLY B 1 32  ? -87.327  61.530 22.705  1.00 55.14  ? 882  GLY B O   1 
ATOM   2253 N N   . ARG B 1 33  ? -85.910  61.291 24.479  1.00 47.66  ? 883  ARG B N   1 
ATOM   2254 C CA  . ARG B 1 33  ? -87.008  61.457 25.443  1.00 49.02  ? 883  ARG B CA  1 
ATOM   2255 C C   . ARG B 1 33  ? -86.809  62.701 26.318  1.00 49.36  ? 883  ARG B C   1 
ATOM   2256 O O   . ARG B 1 33  ? -85.634  62.997 26.603  1.00 49.04  ? 883  ARG B O   1 
ATOM   2257 C CB  . ARG B 1 33  ? -87.033  60.193 26.295  1.00 57.99  ? 883  ARG B CB  1 
ATOM   2258 C CG  . ARG B 1 33  ? -87.215  58.897 25.525  1.00 59.80  ? 883  ARG B CG  1 
ATOM   2259 C CD  . ARG B 1 33  ? -87.382  57.782 26.532  1.00 59.87  ? 883  ARG B CD  1 
ATOM   2260 N NE  . ARG B 1 33  ? -88.072  56.652 25.939  1.00 80.74  ? 883  ARG B NE  1 
ATOM   2261 C CZ  . ARG B 1 33  ? -89.302  56.282 26.271  1.00 82.32  ? 883  ARG B CZ  1 
ATOM   2262 N NH1 . ARG B 1 33  ? -89.976  56.972 27.171  1.00 76.28  ? 883  ARG B NH1 1 
ATOM   2263 N NH2 . ARG B 1 33  ? -89.858  55.234 25.690  1.00 81.40  ? 883  ARG B NH2 1 
ATOM   2264 N N   . VAL B 1 34  ? -87.887  63.408 26.668  1.00 35.86  ? 884  VAL B N   1 
ATOM   2265 C CA  . VAL B 1 34  ? -87.807  64.529 27.653  1.00 44.83  ? 884  VAL B CA  1 
ATOM   2266 C C   . VAL B 1 34  ? -87.708  63.950 29.060  1.00 36.38  ? 884  VAL B C   1 
ATOM   2267 O O   . VAL B 1 34  ? -88.709  63.460 29.580  1.00 35.51  ? 884  VAL B O   1 
ATOM   2268 C CB  . VAL B 1 34  ? -88.999  65.486 27.584  1.00 42.96  ? 884  VAL B CB  1 
ATOM   2269 C CG1 . VAL B 1 34  ? -89.007  66.453 28.755  1.00 45.59  ? 884  VAL B CG1 1 
ATOM   2270 C CG2 . VAL B 1 34  ? -89.007  66.245 26.269  1.00 49.30  ? 884  VAL B CG2 1 
ATOM   2271 N N   . LEU B 1 35  ? -86.525  64.040 29.627  1.00 38.77  ? 885  LEU B N   1 
ATOM   2272 C CA  . LEU B 1 35  ? -86.272  63.442 30.943  1.00 35.94  ? 885  LEU B CA  1 
ATOM   2273 C C   . LEU B 1 35  ? -86.188  64.540 31.995  1.00 27.79  ? 885  LEU B C   1 
ATOM   2274 O O   . LEU B 1 35  ? -85.482  65.502 31.795  1.00 27.11  ? 885  LEU B O   1 
ATOM   2275 C CB  . LEU B 1 35  ? -84.950  62.681 30.861  1.00 40.46  ? 885  LEU B CB  1 
ATOM   2276 C CG  . LEU B 1 35  ? -84.739  61.566 31.877  1.00 38.89  ? 885  LEU B CG  1 
ATOM   2277 C CD1 . LEU B 1 35  ? -84.406  60.272 31.159  1.00 50.75  ? 885  LEU B CD1 1 
ATOM   2278 C CD2 . LEU B 1 35  ? -83.620  61.928 32.836  1.00 50.90  ? 885  LEU B CD2 1 
ATOM   2279 N N   . PHE B 1 36  ? -86.966  64.374 33.050  1.00 29.48  ? 886  PHE B N   1 
ATOM   2280 C CA  . PHE B 1 36  ? -86.826  65.296 34.164  1.00 28.42  ? 886  PHE B CA  1 
ATOM   2281 C C   . PHE B 1 36  ? -85.401  65.192 34.699  1.00 28.41  ? 886  PHE B C   1 
ATOM   2282 O O   . PHE B 1 36  ? -84.931  64.082 34.984  1.00 30.51  ? 886  PHE B O   1 
ATOM   2283 C CB  . PHE B 1 36  ? -87.834  64.992 35.270  1.00 29.56  ? 886  PHE B CB  1 
ATOM   2284 C CG  . PHE B 1 36  ? -87.974  66.100 36.273  1.00 29.38  ? 886  PHE B CG  1 
ATOM   2285 C CD1 . PHE B 1 36  ? -88.725  67.226 35.975  1.00 33.27  ? 886  PHE B CD1 1 
ATOM   2286 C CD2 . PHE B 1 36  ? -87.343  66.028 37.503  1.00 27.13  ? 886  PHE B CD2 1 
ATOM   2287 C CE1 . PHE B 1 36  ? -88.854  68.253 36.888  1.00 29.80  ? 886  PHE B CE1 1 
ATOM   2288 C CE2 . PHE B 1 36  ? -87.468  67.053 38.422  1.00 26.45  ? 886  PHE B CE2 1 
ATOM   2289 C CZ  . PHE B 1 36  ? -88.225  68.167 38.114  1.00 30.77  ? 886  PHE B CZ  1 
ATOM   2290 N N   . PRO B 1 37  ? -84.676  66.300 34.817  1.00 30.16  ? 887  PRO B N   1 
ATOM   2291 C CA  . PRO B 1 37  ? -83.261  66.211 35.190  1.00 24.75  ? 887  PRO B CA  1 
ATOM   2292 C C   . PRO B 1 37  ? -83.076  65.878 36.661  1.00 25.74  ? 887  PRO B C   1 
ATOM   2293 O O   . PRO B 1 37  ? -83.872  66.267 37.520  1.00 26.95  ? 887  PRO B O   1 
ATOM   2294 C CB  . PRO B 1 37  ? -82.717  67.607 34.869  1.00 30.37  ? 887  PRO B CB  1 
ATOM   2295 C CG  . PRO B 1 37  ? -83.903  68.507 34.902  1.00 30.73  ? 887  PRO B CG  1 
ATOM   2296 C CD  . PRO B 1 37  ? -85.116  67.685 34.575  1.00 26.90  ? 887  PRO B CD  1 
ATOM   2297 N N   . ALA B 1 38  ? -82.006  65.127 36.937  1.00 32.16  ? 888  ALA B N   1 
ATOM   2298 C CA  . ALA B 1 38  ? -81.599  64.857 38.314  1.00 27.78  ? 888  ALA B CA  1 
ATOM   2299 C C   . ALA B 1 38  ? -81.484  66.147 39.131  1.00 27.78  ? 888  ALA B C   1 
ATOM   2300 O O   . ALA B 1 38  ? -81.866  66.200 40.317  1.00 28.33  ? 888  ALA B O   1 
ATOM   2301 C CB  . ALA B 1 38  ? -80.269  64.098 38.304  1.00 28.67  ? 888  ALA B CB  1 
ATOM   2302 N N   . THR B 1 39  ? -80.966  67.209 38.510  1.00 28.63  ? 889  THR B N   1 
ATOM   2303 C CA  . THR B 1 39  ? -80.835  68.469 39.228  1.00 24.42  ? 889  THR B CA  1 
ATOM   2304 C C   . THR B 1 39  ? -82.195  69.111 39.496  1.00 24.55  ? 889  THR B C   1 
ATOM   2305 O O   . THR B 1 39  ? -82.318  69.926 40.420  1.00 28.11  ? 889  THR B O   1 
ATOM   2306 C CB  . THR B 1 39  ? -79.909  69.416 38.462  1.00 28.69  ? 889  THR B CB  1 
ATOM   2307 O OG1 . THR B 1 39  ? -80.429  69.652 37.150  1.00 26.67  ? 889  THR B OG1 1 
ATOM   2308 C CG2 . THR B 1 39  ? -78.525  68.785 38.328  1.00 25.60  ? 889  THR B CG2 1 
ATOM   2309 N N   . GLY B 1 40  ? -83.227  68.726 38.741  1.00 24.76  ? 890  GLY B N   1 
ATOM   2310 C CA  . GLY B 1 40  ? -84.578  69.139 39.088  1.00 28.81  ? 890  GLY B CA  1 
ATOM   2311 C C   . GLY B 1 40  ? -85.066  68.511 40.383  1.00 26.96  ? 890  GLY B C   1 
ATOM   2312 O O   . GLY B 1 40  ? -85.787  69.148 41.165  1.00 25.88  ? 890  GLY B O   1 
ATOM   2313 N N   . TYR B 1 41  ? -84.687  67.251 40.630  1.00 24.95  ? 891  TYR B N   1 
ATOM   2314 C CA  . TYR B 1 41  ? -85.003  66.650 41.922  1.00 24.71  ? 891  TYR B CA  1 
ATOM   2315 C C   . TYR B 1 41  ? -84.296  67.392 43.039  1.00 27.86  ? 891  TYR B C   1 
ATOM   2316 O O   . TYR B 1 41  ? -84.893  67.656 44.095  1.00 26.71  ? 891  TYR B O   1 
ATOM   2317 C CB  . TYR B 1 41  ? -84.611  65.173 41.964  1.00 24.77  ? 891  TYR B CB  1 
ATOM   2318 C CG  . TYR B 1 41  ? -85.234  64.319 40.894  1.00 28.01  ? 891  TYR B CG  1 
ATOM   2319 C CD1 . TYR B 1 41  ? -86.614  64.236 40.748  1.00 28.23  ? 891  TYR B CD1 1 
ATOM   2320 C CD2 . TYR B 1 41  ? -84.438  63.574 40.041  1.00 28.00  ? 891  TYR B CD2 1 
ATOM   2321 C CE1 . TYR B 1 41  ? -87.177  63.443 39.764  1.00 27.51  ? 891  TYR B CE1 1 
ATOM   2322 C CE2 . TYR B 1 41  ? -84.987  62.783 39.062  1.00 31.10  ? 891  TYR B CE2 1 
ATOM   2323 C CZ  . TYR B 1 41  ? -86.353  62.719 38.925  1.00 30.51  ? 891  TYR B CZ  1 
ATOM   2324 O OH  . TYR B 1 41  ? -86.880  61.921 37.939  1.00 31.44  ? 891  TYR B OH  1 
ATOM   2325 N N   . LEU B 1 42  ? -83.015  67.726 42.835  1.00 26.05  ? 892  LEU B N   1 
ATOM   2326 C CA  . LEU B 1 42  ? -82.335  68.528 43.852  1.00 28.14  ? 892  LEU B CA  1 
ATOM   2327 C C   . LEU B 1 42  ? -83.094  69.823 44.123  1.00 26.67  ? 892  LEU B C   1 
ATOM   2328 O O   . LEU B 1 42  ? -83.273  70.218 45.284  1.00 26.48  ? 892  LEU B O   1 
ATOM   2329 C CB  . LEU B 1 42  ? -80.899  68.835 43.435  1.00 26.47  ? 892  LEU B CB  1 
ATOM   2330 C CG  . LEU B 1 42  ? -79.977  67.649 43.163  1.00 27.76  ? 892  LEU B CG  1 
ATOM   2331 C CD1 . LEU B 1 42  ? -78.604  68.155 42.742  1.00 31.90  ? 892  LEU B CD1 1 
ATOM   2332 C CD2 . LEU B 1 42  ? -79.884  66.717 44.369  1.00 29.58  ? 892  LEU B CD2 1 
ATOM   2333 N N   . SER B 1 43  ? -83.572  70.479 43.062  1.00 25.21  ? 893  SER B N   1 
ATOM   2334 C CA  . SER B 1 43  ? -84.283  71.746 43.223  1.00 26.83  ? 893  SER B CA  1 
ATOM   2335 C C   . SER B 1 43  ? -85.540  71.588 44.073  1.00 25.46  ? 893  SER B C   1 
ATOM   2336 O O   . SER B 1 43  ? -85.772  72.367 45.008  1.00 27.06  ? 893  SER B O   1 
ATOM   2337 C CB  . SER B 1 43  ? -84.640  72.315 41.852  1.00 28.86  ? 893  SER B CB  1 
ATOM   2338 O OG  . SER B 1 43  ? -85.416  73.494 41.971  1.00 29.52  ? 893  SER B OG  1 
ATOM   2339 N N   . ILE B 1 44  ? -86.378  70.596 43.756  1.00 24.15  ? 894  ILE B N   1 
ATOM   2340 C CA  . ILE B 1 44  ? -87.641  70.508 44.493  1.00 23.17  ? 894  ILE B CA  1 
ATOM   2341 C C   . ILE B 1 44  ? -87.421  70.017 45.927  1.00 26.00  ? 894  ILE B C   1 
ATOM   2342 O O   . ILE B 1 44  ? -88.153  70.421 46.846  1.00 26.38  ? 894  ILE B O   1 
ATOM   2343 C CB  . ILE B 1 44  ? -88.676  69.653 43.735  1.00 24.53  ? 894  ILE B CB  1 
ATOM   2344 C CG1 . ILE B 1 44  ? -88.229  68.197 43.606  1.00 25.23  ? 894  ILE B CG1 1 
ATOM   2345 C CG2 . ILE B 1 44  ? -88.986  70.273 42.373  1.00 28.80  ? 894  ILE B CG2 1 
ATOM   2346 C CD1 . ILE B 1 44  ? -89.298  67.302 43.000  1.00 26.36  ? 894  ILE B CD1 1 
ATOM   2347 N N   . VAL B 1 45  ? -86.397  69.192 46.167  1.00 24.63  ? 895  VAL B N   1 
ATOM   2348 C CA  . VAL B 1 45  ? -86.087  68.809 47.545  1.00 23.61  ? 895  VAL B CA  1 
ATOM   2349 C C   . VAL B 1 45  ? -85.605  70.019 48.344  1.00 26.26  ? 895  VAL B C   1 
ATOM   2350 O O   . VAL B 1 45  ? -85.999  70.221 49.504  1.00 26.87  ? 895  VAL B O   1 
ATOM   2351 C CB  . VAL B 1 45  ? -85.050  67.671 47.559  1.00 24.63  ? 895  VAL B CB  1 
ATOM   2352 C CG1 . VAL B 1 45  ? -84.583  67.388 48.980  1.00 24.02  ? 895  VAL B CG1 1 
ATOM   2353 C CG2 . VAL B 1 45  ? -85.627  66.422 46.923  1.00 22.72  ? 895  VAL B CG2 1 
ATOM   2354 N N   . TRP B 1 46  ? -84.719  70.819 47.744  1.00 24.32  ? 896  TRP B N   1 
ATOM   2355 C CA  . TRP B 1 46  ? -84.240  72.053 48.358  1.00 27.06  ? 896  TRP B CA  1 
ATOM   2356 C C   . TRP B 1 46  ? -85.397  72.980 48.708  1.00 28.13  ? 896  TRP B C   1 
ATOM   2357 O O   . TRP B 1 46  ? -85.434  73.562 49.801  1.00 26.02  ? 896  TRP B O   1 
ATOM   2358 C CB  . TRP B 1 46  ? -83.271  72.721 47.383  1.00 24.82  ? 896  TRP B CB  1 
ATOM   2359 C CG  . TRP B 1 46  ? -82.434  73.855 47.880  1.00 26.32  ? 896  TRP B CG  1 
ATOM   2360 C CD1 . TRP B 1 46  ? -82.252  74.264 49.169  1.00 27.59  ? 896  TRP B CD1 1 
ATOM   2361 C CD2 . TRP B 1 46  ? -81.622  74.708 47.068  1.00 23.96  ? 896  TRP B CD2 1 
ATOM   2362 N NE1 . TRP B 1 46  ? -81.386  75.335 49.205  1.00 29.37  ? 896  TRP B NE1 1 
ATOM   2363 C CE2 . TRP B 1 46  ? -80.986  75.625 47.926  1.00 29.03  ? 896  TRP B CE2 1 
ATOM   2364 C CE3 . TRP B 1 46  ? -81.378  74.789 45.693  1.00 27.97  ? 896  TRP B CE3 1 
ATOM   2365 C CZ2 . TRP B 1 46  ? -80.121  76.611 47.454  1.00 30.55  ? 896  TRP B CZ2 1 
ATOM   2366 C CZ3 . TRP B 1 46  ? -80.523  75.766 45.226  1.00 27.83  ? 896  TRP B CZ3 1 
ATOM   2367 C CH2 . TRP B 1 46  ? -79.904  76.664 46.103  1.00 27.43  ? 896  TRP B CH2 1 
ATOM   2368 N N   . LYS B 1 47  ? -86.352  73.128 47.783  1.00 25.25  ? 897  LYS B N   1 
ATOM   2369 C CA  . LYS B 1 47  ? -87.517  73.974 48.025  1.00 26.07  ? 897  LYS B CA  1 
ATOM   2370 C C   . LYS B 1 47  ? -88.371  73.432 49.167  1.00 27.80  ? 897  LYS B C   1 
ATOM   2371 O O   . LYS B 1 47  ? -88.946  74.209 49.944  1.00 27.98  ? 897  LYS B O   1 
ATOM   2372 C CB  . LYS B 1 47  ? -88.344  74.077 46.740  1.00 26.69  ? 897  LYS B CB  1 
ATOM   2373 C CG  . LYS B 1 47  ? -87.756  74.994 45.668  1.00 30.21  ? 897  LYS B CG  1 
ATOM   2374 C CD  . LYS B 1 47  ? -88.693  75.094 44.468  1.00 30.87  ? 897  LYS B CD  1 
ATOM   2375 C CE  . LYS B 1 47  ? -88.115  75.960 43.358  1.00 33.28  ? 897  LYS B CE  1 
ATOM   2376 N NZ  . LYS B 1 47  ? -89.000  75.973 42.159  1.00 28.41  ? 897  LYS B NZ  1 
ATOM   2377 N N   . THR B 1 48  ? -88.438  72.105 49.309  1.00 26.17  ? 898  THR B N   1 
ATOM   2378 C CA  . THR B 1 48  ? -89.225  71.518 50.391  1.00 27.03  ? 898  THR B CA  1 
ATOM   2379 C C   . THR B 1 48  ? -88.569  71.756 51.754  1.00 29.17  ? 898  THR B C   1 
ATOM   2380 O O   . THR B 1 48  ? -89.251  72.102 52.737  1.00 28.50  ? 898  THR B O   1 
ATOM   2381 C CB  . THR B 1 48  ? -89.419  70.026 50.116  1.00 24.60  ? 898  THR B CB  1 
ATOM   2382 O OG1 . THR B 1 48  ? -89.962  69.858 48.799  1.00 25.42  ? 898  THR B OG1 1 
ATOM   2383 C CG2 . THR B 1 48  ? -90.371  69.406 51.123  1.00 25.31  ? 898  THR B CG2 1 
ATOM   2384 N N   . LEU B 1 49  ? -87.243  71.596 51.829  1.00 27.40  ? 899  LEU B N   1 
ATOM   2385 C CA  . LEU B 1 49  ? -86.535  71.938 53.064  1.00 26.43  ? 899  LEU B CA  1 
ATOM   2386 C C   . LEU B 1 49  ? -86.697  73.418 53.395  1.00 29.34  ? 899  LEU B C   1 
ATOM   2387 O O   . LEU B 1 49  ? -86.940  73.780 54.554  1.00 30.96  ? 899  LEU B O   1 
ATOM   2388 C CB  . LEU B 1 49  ? -85.052  71.575 52.957  1.00 25.99  ? 899  LEU B CB  1 
ATOM   2389 C CG  . LEU B 1 49  ? -84.176  71.895 54.178  1.00 30.58  ? 899  LEU B CG  1 
ATOM   2390 C CD1 . LEU B 1 49  ? -84.677  71.174 55.427  1.00 29.87  ? 899  LEU B CD1 1 
ATOM   2391 C CD2 . LEU B 1 49  ? -82.706  71.570 53.916  1.00 28.71  ? 899  LEU B CD2 1 
ATOM   2392 N N   . ALA B 1 50  ? -86.577  74.286 52.385  1.00 28.22  ? 900  ALA B N   1 
ATOM   2393 C CA  . ALA B 1 50  ? -86.753  75.720 52.597  1.00 28.59  ? 900  ALA B CA  1 
ATOM   2394 C C   . ALA B 1 50  ? -88.127  76.033 53.173  1.00 29.63  ? 900  ALA B C   1 
ATOM   2395 O O   . ALA B 1 50  ? -88.255  76.873 54.072  1.00 33.28  ? 900  ALA B O   1 
ATOM   2396 C CB  . ALA B 1 50  ? -86.542  76.471 51.283  1.00 29.60  ? 900  ALA B CB  1 
ATOM   2397 N N   . ARG B 1 51  ? -89.170  75.380 52.651  1.00 30.26  ? 901  ARG B N   1 
ATOM   2398 C CA  . ARG B 1 51  ? -90.509  75.576 53.198  1.00 31.62  ? 901  ARG B CA  1 
ATOM   2399 C C   . ARG B 1 51  ? -90.566  75.176 54.664  1.00 35.89  ? 901  ARG B C   1 
ATOM   2400 O O   . ARG B 1 51  ? -91.152  75.890 55.489  1.00 36.48  ? 901  ARG B O   1 
ATOM   2401 C CB  . ARG B 1 51  ? -91.530  74.768 52.401  1.00 32.37  ? 901  ARG B CB  1 
ATOM   2402 C CG  . ARG B 1 51  ? -92.973  75.196 52.618  1.00 30.44  ? 901  ARG B CG  1 
ATOM   2403 C CD  . ARG B 1 51  ? -93.240  76.551 51.983  1.00 32.09  ? 901  ARG B CD  1 
ATOM   2404 N NE  . ARG B 1 51  ? -94.637  76.951 52.100  1.00 34.91  ? 901  ARG B NE  1 
ATOM   2405 C CZ  . ARG B 1 51  ? -95.201  77.916 51.386  1.00 38.43  ? 901  ARG B CZ  1 
ATOM   2406 N NH1 . ARG B 1 51  ? -94.510  78.614 50.499  1.00 33.93  ? 901  ARG B NH1 1 
ATOM   2407 N NH2 . ARG B 1 51  ? -96.492  78.185 51.563  1.00 32.43  ? 901  ARG B NH2 1 
ATOM   2408 N N   . ALA B 1 52  ? -89.961  74.034 55.008  1.00 31.39  ? 902  ALA B N   1 
ATOM   2409 C CA  . ALA B 1 52  ? -89.996  73.587 56.398  1.00 33.21  ? 902  ALA B CA  1 
ATOM   2410 C C   . ALA B 1 52  ? -89.270  74.551 57.330  1.00 41.57  ? 902  ALA B C   1 
ATOM   2411 O O   . ALA B 1 52  ? -89.625  74.662 58.510  1.00 37.83  ? 902  ALA B O   1 
ATOM   2412 C CB  . ALA B 1 52  ? -89.393  72.188 56.512  1.00 31.34  ? 902  ALA B CB  1 
ATOM   2413 N N   . LEU B 1 53  ? -88.264  75.258 56.825  1.00 34.55  ? 903  LEU B N   1 
ATOM   2414 C CA  . LEU B 1 53  ? -87.464  76.166 57.634  1.00 37.24  ? 903  LEU B CA  1 
ATOM   2415 C C   . LEU B 1 53  ? -87.957  77.606 57.568  1.00 39.89  ? 903  LEU B C   1 
ATOM   2416 O O   . LEU B 1 53  ? -87.362  78.479 58.209  1.00 43.62  ? 903  LEU B O   1 
ATOM   2417 C CB  . LEU B 1 53  ? -85.998  76.097 57.196  1.00 34.16  ? 903  LEU B CB  1 
ATOM   2418 C CG  . LEU B 1 53  ? -85.318  74.737 57.393  1.00 37.35  ? 903  LEU B CG  1 
ATOM   2419 C CD1 . LEU B 1 53  ? -83.933  74.721 56.752  1.00 32.85  ? 903  LEU B CD1 1 
ATOM   2420 C CD2 . LEU B 1 53  ? -85.254  74.326 58.861  1.00 46.13  ? 903  LEU B CD2 1 
ATOM   2421 N N   . GLY B 1 54  ? -89.000  77.879 56.788  1.00 35.59  ? 904  GLY B N   1 
ATOM   2422 C CA  . GLY B 1 54  ? -89.474  79.241 56.634  1.00 39.67  ? 904  GLY B CA  1 
ATOM   2423 C C   . GLY B 1 54  ? -88.508  80.136 55.895  1.00 44.78  ? 904  GLY B C   1 
ATOM   2424 O O   . GLY B 1 54  ? -88.458  81.340 56.164  1.00 46.32  ? 904  GLY B O   1 
ATOM   2425 N N   . LEU B 1 55  ? -87.725  79.572 54.979  1.00 36.60  ? 905  LEU B N   1 
ATOM   2426 C CA  . LEU B 1 55  ? -86.693  80.293 54.253  1.00 34.67  ? 905  LEU B CA  1 
ATOM   2427 C C   . LEU B 1 55  ? -86.951  80.203 52.754  1.00 38.75  ? 905  LEU B C   1 
ATOM   2428 O O   . LEU B 1 55  ? -87.659  79.313 52.278  1.00 38.44  ? 905  LEU B O   1 
ATOM   2429 C CB  . LEU B 1 55  ? -85.304  79.717 54.564  1.00 36.31  ? 905  LEU B CB  1 
ATOM   2430 C CG  . LEU B 1 55  ? -84.782  79.813 55.998  1.00 40.04  ? 905  LEU B CG  1 
ATOM   2431 C CD1 . LEU B 1 55  ? -83.540  78.949 56.168  1.00 38.90  ? 905  LEU B CD1 1 
ATOM   2432 C CD2 . LEU B 1 55  ? -84.486  81.254 56.366  1.00 43.58  ? 905  LEU B CD2 1 
ATOM   2433 N N   . GLY B 1 56  ? -86.362  81.137 52.014  1.00 39.51  ? 906  GLY B N   1 
ATOM   2434 C CA  . GLY B 1 56  ? -86.198  80.981 50.581  1.00 38.09  ? 906  GLY B CA  1 
ATOM   2435 C C   . GLY B 1 56  ? -84.915  80.222 50.287  1.00 36.63  ? 906  GLY B C   1 
ATOM   2436 O O   . GLY B 1 56  ? -83.991  80.219 51.094  1.00 34.82  ? 906  GLY B O   1 
ATOM   2437 N N   . VAL B 1 57  ? -84.871  79.541 49.135  1.00 32.65  ? 907  VAL B N   1 
ATOM   2438 C CA  . VAL B 1 57  ? -83.678  78.751 48.821  1.00 34.81  ? 907  VAL B CA  1 
ATOM   2439 C C   . VAL B 1 57  ? -82.434  79.629 48.795  1.00 33.89  ? 907  VAL B C   1 
ATOM   2440 O O   . VAL B 1 57  ? -81.344  79.180 49.169  1.00 34.57  ? 907  VAL B O   1 
ATOM   2441 C CB  . VAL B 1 57  ? -83.834  77.970 47.497  1.00 35.09  ? 907  VAL B CB  1 
ATOM   2442 C CG1 . VAL B 1 57  ? -84.923  76.910 47.616  1.00 30.97  ? 907  VAL B CG1 1 
ATOM   2443 C CG2 . VAL B 1 57  ? -84.079  78.905 46.316  1.00 34.65  ? 907  VAL B CG2 1 
ATOM   2444 N N   . GLU B 1 58  ? -82.561  80.885 48.360  1.00 35.30  ? 908  GLU B N   1 
ATOM   2445 C CA  . GLU B 1 58  ? -81.385  81.746 48.316  1.00 34.44  ? 908  GLU B CA  1 
ATOM   2446 C C   . GLU B 1 58  ? -80.833  82.072 49.698  1.00 38.99  ? 908  GLU B C   1 
ATOM   2447 O O   . GLU B 1 58  ? -79.692  82.536 49.790  1.00 43.94  ? 908  GLU B O   1 
ATOM   2448 C CB  . GLU B 1 58  ? -81.687  83.031 47.547  1.00 41.88  ? 908  GLU B CB  1 
ATOM   2449 C CG  . GLU B 1 58  ? -82.207  82.763 46.148  1.00 45.02  ? 908  GLU B CG  1 
ATOM   2450 C CD  . GLU B 1 58  ? -81.101  82.408 45.172  1.00 52.18  ? 908  GLU B CD  1 
ATOM   2451 O OE1 . GLU B 1 58  ? -79.952  82.858 45.368  1.00 53.62  ? 908  GLU B OE1 1 
ATOM   2452 O OE2 . GLU B 1 58  ? -81.382  81.657 44.214  1.00 41.91  ? 908  GLU B OE2 1 
ATOM   2453 N N   . GLN B 1 59  ? -81.590  81.829 50.768  1.00 38.21  ? 909  GLN B N   1 
ATOM   2454 C CA  . GLN B 1 59  ? -81.078  82.001 52.121  1.00 37.73  ? 909  GLN B CA  1 
ATOM   2455 C C   . GLN B 1 59  ? -80.759  80.672 52.777  1.00 35.94  ? 909  GLN B C   1 
ATOM   2456 O O   . GLN B 1 59  ? -80.585  80.620 53.998  1.00 36.61  ? 909  GLN B O   1 
ATOM   2457 C CB  . GLN B 1 59  ? -82.082  82.742 53.003  1.00 39.65  ? 909  GLN B CB  1 
ATOM   2458 C CG  . GLN B 1 59  ? -82.294  84.179 52.646  1.00 47.66  ? 909  GLN B CG  1 
ATOM   2459 C CD  . GLN B 1 59  ? -83.618  84.376 51.954  1.00 52.48  ? 909  GLN B CD  1 
ATOM   2460 O OE1 . GLN B 1 59  ? -83.674  84.831 50.815  1.00 51.99  ? 909  GLN B OE1 1 
ATOM   2461 N NE2 . GLN B 1 59  ? -84.701  84.038 52.647  1.00 52.61  ? 909  GLN B NE2 1 
ATOM   2462 N N   . LEU B 1 60  ? -80.708  79.592 52.002  1.00 36.59  ? 910  LEU B N   1 
ATOM   2463 C CA  . LEU B 1 60  ? -80.565  78.245 52.544  1.00 32.66  ? 910  LEU B CA  1 
ATOM   2464 C C   . LEU B 1 60  ? -79.376  77.548 51.900  1.00 32.59  ? 910  LEU B C   1 
ATOM   2465 O O   . LEU B 1 60  ? -79.534  76.803 50.923  1.00 31.90  ? 910  LEU B O   1 
ATOM   2466 C CB  . LEU B 1 60  ? -81.840  77.432 52.326  1.00 27.54  ? 910  LEU B CB  1 
ATOM   2467 C CG  . LEU B 1 60  ? -81.859  75.995 52.867  1.00 32.88  ? 910  LEU B CG  1 
ATOM   2468 C CD1 . LEU B 1 60  ? -81.240  75.894 54.256  1.00 31.15  ? 910  LEU B CD1 1 
ATOM   2469 C CD2 . LEU B 1 60  ? -83.247  75.371 52.828  1.00 32.54  ? 910  LEU B CD2 1 
ATOM   2470 N N   . PRO B 1 61  ? -78.171  77.749 52.426  1.00 30.90  ? 911  PRO B N   1 
ATOM   2471 C CA  . PRO B 1 61  ? -77.073  76.848 52.064  1.00 29.03  ? 911  PRO B CA  1 
ATOM   2472 C C   . PRO B 1 61  ? -77.439  75.436 52.489  1.00 29.77  ? 911  PRO B C   1 
ATOM   2473 O O   . PRO B 1 61  ? -78.010  75.221 53.560  1.00 31.08  ? 911  PRO B O   1 
ATOM   2474 C CB  . PRO B 1 61  ? -75.874  77.398 52.843  1.00 32.46  ? 911  PRO B CB  1 
ATOM   2475 C CG  . PRO B 1 61  ? -76.439  78.318 53.873  1.00 37.86  ? 911  PRO B CG  1 
ATOM   2476 C CD  . PRO B 1 61  ? -77.772  78.784 53.394  1.00 35.73  ? 911  PRO B CD  1 
ATOM   2477 N N   . VAL B 1 62  ? -77.144  74.470 51.622  1.00 25.90  ? 912  VAL B N   1 
ATOM   2478 C CA  . VAL B 1 62  ? -77.734  73.144 51.747  1.00 25.98  ? 912  VAL B CA  1 
ATOM   2479 C C   . VAL B 1 62  ? -76.718  72.074 51.366  1.00 29.54  ? 912  VAL B C   1 
ATOM   2480 O O   . VAL B 1 62  ? -75.847  72.285 50.514  1.00 27.95  ? 912  VAL B O   1 
ATOM   2481 C CB  . VAL B 1 62  ? -79.014  73.036 50.882  1.00 28.16  ? 912  VAL B CB  1 
ATOM   2482 C CG1 . VAL B 1 62  ? -78.682  73.188 49.400  1.00 27.17  ? 912  VAL B CG1 1 
ATOM   2483 C CG2 . VAL B 1 62  ? -79.755  71.739 51.155  1.00 27.28  ? 912  VAL B CG2 1 
ATOM   2484 N N   . VAL B 1 63  ? -76.824  70.921 52.026  1.00 25.30  ? 913  VAL B N   1 
ATOM   2485 C CA  . VAL B 1 63  ? -76.035  69.738 51.703  1.00 28.51  ? 913  VAL B CA  1 
ATOM   2486 C C   . VAL B 1 63  ? -76.983  68.595 51.364  1.00 27.67  ? 913  VAL B C   1 
ATOM   2487 O O   . VAL B 1 63  ? -77.935  68.331 52.107  1.00 27.27  ? 913  VAL B O   1 
ATOM   2488 C CB  . VAL B 1 63  ? -75.106  69.335 52.864  1.00 26.73  ? 913  VAL B CB  1 
ATOM   2489 C CG1 . VAL B 1 63  ? -74.157  68.227 52.423  1.00 30.23  ? 913  VAL B CG1 1 
ATOM   2490 C CG2 . VAL B 1 63  ? -74.330  70.535 53.374  1.00 30.36  ? 913  VAL B CG2 1 
ATOM   2491 N N   . PHE B 1 64  ? -76.711  67.914 50.254  1.00 25.30  ? 914  PHE B N   1 
ATOM   2492 C CA  . PHE B 1 64  ? -77.314  66.631 49.922  1.00 25.92  ? 914  PHE B CA  1 
ATOM   2493 C C   . PHE B 1 64  ? -76.268  65.548 50.126  1.00 29.49  ? 914  PHE B C   1 
ATOM   2494 O O   . PHE B 1 64  ? -75.108  65.726 49.749  1.00 27.81  ? 914  PHE B O   1 
ATOM   2495 C CB  . PHE B 1 64  ? -77.786  66.572 48.467  1.00 25.90  ? 914  PHE B CB  1 
ATOM   2496 C CG  . PHE B 1 64  ? -78.869  67.543 48.130  1.00 25.44  ? 914  PHE B CG  1 
ATOM   2497 C CD1 . PHE B 1 64  ? -78.568  68.864 47.854  1.00 27.28  ? 914  PHE B CD1 1 
ATOM   2498 C CD2 . PHE B 1 64  ? -80.189  67.134 48.085  1.00 28.82  ? 914  PHE B CD2 1 
ATOM   2499 C CE1 . PHE B 1 64  ? -79.564  69.761 47.536  1.00 30.31  ? 914  PHE B CE1 1 
ATOM   2500 C CE2 . PHE B 1 64  ? -81.191  68.025 47.771  1.00 30.92  ? 914  PHE B CE2 1 
ATOM   2501 C CZ  . PHE B 1 64  ? -80.879  69.341 47.497  1.00 30.85  ? 914  PHE B CZ  1 
ATOM   2502 N N   . GLU B 1 65  ? -76.675  64.420 50.700  1.00 24.59  ? 915  GLU B N   1 
ATOM   2503 C CA  . GLU B 1 65  ? -75.767  63.299 50.894  1.00 26.73  ? 915  GLU B CA  1 
ATOM   2504 C C   . GLU B 1 65  ? -76.436  61.984 50.520  1.00 30.67  ? 915  GLU B C   1 
ATOM   2505 O O   . GLU B 1 65  ? -77.644  61.807 50.688  1.00 27.01  ? 915  GLU B O   1 
ATOM   2506 C CB  . GLU B 1 65  ? -75.236  63.225 52.335  1.00 25.86  ? 915  GLU B CB  1 
ATOM   2507 C CG  . GLU B 1 65  ? -74.178  64.278 52.616  1.00 30.50  ? 915  GLU B CG  1 
ATOM   2508 C CD  . GLU B 1 65  ? -73.771  64.380 54.074  1.00 34.84  ? 915  GLU B CD  1 
ATOM   2509 O OE1 . GLU B 1 65  ? -74.333  63.659 54.925  1.00 31.93  ? 915  GLU B OE1 1 
ATOM   2510 O OE2 . GLU B 1 65  ? -72.874  65.199 54.365  1.00 33.22  ? 915  GLU B OE2 1 
ATOM   2511 N N   . ASP B 1 66  ? -75.621  61.067 49.999  1.00 24.94  ? 916  ASP B N   1 
ATOM   2512 C CA  . ASP B 1 66  ? -76.039  59.695 49.709  1.00 27.60  ? 916  ASP B CA  1 
ATOM   2513 C C   . ASP B 1 66  ? -77.275  59.656 48.810  1.00 29.29  ? 916  ASP B C   1 
ATOM   2514 O O   . ASP B 1 66  ? -78.199  58.868 49.021  1.00 26.71  ? 916  ASP B O   1 
ATOM   2515 C CB  . ASP B 1 66  ? -76.293  58.934 51.013  1.00 30.04  ? 916  ASP B CB  1 
ATOM   2516 C CG  . ASP B 1 66  ? -75.110  58.997 51.965  1.00 36.79  ? 916  ASP B CG  1 
ATOM   2517 O OD1 . ASP B 1 66  ? -73.961  58.889 51.492  1.00 34.10  ? 916  ASP B OD1 1 
ATOM   2518 O OD2 . ASP B 1 66  ? -75.326  59.164 53.184  1.00 35.45  ? 916  ASP B OD2 1 
ATOM   2519 N N   . VAL B 1 67  ? -77.279  60.500 47.778  1.00 27.37  ? 917  VAL B N   1 
ATOM   2520 C CA  . VAL B 1 67  ? -78.407  60.556 46.854  1.00 26.62  ? 917  VAL B CA  1 
ATOM   2521 C C   . VAL B 1 67  ? -78.410  59.318 45.969  1.00 31.51  ? 917  VAL B C   1 
ATOM   2522 O O   . VAL B 1 67  ? -77.366  58.903 45.449  1.00 30.19  ? 917  VAL B O   1 
ATOM   2523 C CB  . VAL B 1 67  ? -78.354  61.840 46.012  1.00 27.62  ? 917  VAL B CB  1 
ATOM   2524 C CG1 . VAL B 1 67  ? -79.517  61.881 45.019  1.00 26.77  ? 917  VAL B CG1 1 
ATOM   2525 C CG2 . VAL B 1 67  ? -78.357  63.065 46.911  1.00 28.29  ? 917  VAL B CG2 1 
ATOM   2526 N N   . VAL B 1 68  ? -79.579  58.699 45.825  1.00 25.70  ? 918  VAL B N   1 
ATOM   2527 C CA  . VAL B 1 68  ? -79.766  57.538 44.962  1.00 27.81  ? 918  VAL B CA  1 
ATOM   2528 C C   . VAL B 1 68  ? -80.936  57.828 44.034  1.00 29.71  ? 918  VAL B C   1 
ATOM   2529 O O   . VAL B 1 68  ? -82.025  58.185 44.497  1.00 27.81  ? 918  VAL B O   1 
ATOM   2530 C CB  . VAL B 1 68  ? -80.029  56.249 45.764  1.00 28.60  ? 918  VAL B CB  1 
ATOM   2531 C CG1 . VAL B 1 68  ? -80.261  55.072 44.820  1.00 32.89  ? 918  VAL B CG1 1 
ATOM   2532 C CG2 . VAL B 1 68  ? -78.878  55.968 46.715  1.00 28.75  ? 918  VAL B CG2 1 
ATOM   2533 N N   . LEU B 1 69  ? -80.711  57.697 42.732  1.00 28.45  ? 919  LEU B N   1 
ATOM   2534 C CA  . LEU B 1 69  ? -81.762  57.885 41.740  1.00 28.85  ? 919  LEU B CA  1 
ATOM   2535 C C   . LEU B 1 69  ? -82.239  56.504 41.314  1.00 33.61  ? 919  LEU B C   1 
ATOM   2536 O O   . LEU B 1 69  ? -81.481  55.732 40.718  1.00 32.36  ? 919  LEU B O   1 
ATOM   2537 C CB  . LEU B 1 69  ? -81.261  58.710 40.558  1.00 27.39  ? 919  LEU B CB  1 
ATOM   2538 C CG  . LEU B 1 69  ? -80.847  60.115 41.003  1.00 32.22  ? 919  LEU B CG  1 
ATOM   2539 C CD1 . LEU B 1 69  ? -79.333  60.231 41.186  1.00 34.00  ? 919  LEU B CD1 1 
ATOM   2540 C CD2 . LEU B 1 69  ? -81.381  61.171 40.052  1.00 36.54  ? 919  LEU B CD2 1 
ATOM   2541 N N   . HIS B 1 70  ? -83.491  56.187 41.638  1.00 27.82  ? 920  HIS B N   1 
ATOM   2542 C CA  . HIS B 1 70  ? -83.994  54.832 41.471  1.00 30.26  ? 920  HIS B CA  1 
ATOM   2543 C C   . HIS B 1 70  ? -84.603  54.582 40.102  1.00 33.46  ? 920  HIS B C   1 
ATOM   2544 O O   . HIS B 1 70  ? -84.648  53.428 39.661  1.00 34.20  ? 920  HIS B O   1 
ATOM   2545 C CB  . HIS B 1 70  ? -85.029  54.522 42.555  1.00 28.78  ? 920  HIS B CB  1 
ATOM   2546 C CG  . HIS B 1 70  ? -84.495  54.659 43.946  1.00 30.32  ? 920  HIS B CG  1 
ATOM   2547 N ND1 . HIS B 1 70  ? -83.932  53.606 44.634  1.00 35.08  ? 920  HIS B ND1 1 
ATOM   2548 C CD2 . HIS B 1 70  ? -84.435  55.726 44.777  1.00 29.71  ? 920  HIS B CD2 1 
ATOM   2549 C CE1 . HIS B 1 70  ? -83.547  54.018 45.828  1.00 35.33  ? 920  HIS B CE1 1 
ATOM   2550 N NE2 . HIS B 1 70  ? -83.842  55.301 45.941  1.00 32.89  ? 920  HIS B NE2 1 
ATOM   2551 N N   . GLN B 1 71  ? -85.060  55.626 39.421  1.00 30.74  ? 921  GLN B N   1 
ATOM   2552 C CA  . GLN B 1 71  ? -85.616  55.473 38.087  1.00 32.27  ? 921  GLN B CA  1 
ATOM   2553 C C   . GLN B 1 71  ? -85.624  56.839 37.426  1.00 35.79  ? 921  GLN B C   1 
ATOM   2554 O O   . GLN B 1 71  ? -85.563  57.874 38.095  1.00 37.98  ? 921  GLN B O   1 
ATOM   2555 C CB  . GLN B 1 71  ? -87.030  54.875 38.120  1.00 38.48  ? 921  GLN B CB  1 
ATOM   2556 C CG  . GLN B 1 71  ? -88.086  55.755 38.781  1.00 39.70  ? 921  GLN B CG  1 
ATOM   2557 C CD  . GLN B 1 71  ? -89.478  55.146 38.713  1.00 48.29  ? 921  GLN B CD  1 
ATOM   2558 O OE1 . GLN B 1 71  ? -89.682  53.991 39.087  1.00 49.25  ? 921  GLN B OE1 1 
ATOM   2559 N NE2 . GLN B 1 71  ? -90.440  55.919 38.222  1.00 50.21  ? 921  GLN B NE2 1 
ATOM   2560 N N   . ALA B 1 72  ? -85.709  56.828 36.106  1.00 32.34  ? 922  ALA B N   1 
ATOM   2561 C CA  . ALA B 1 72  ? -85.823  58.068 35.364  1.00 37.93  ? 922  ALA B CA  1 
ATOM   2562 C C   . ALA B 1 72  ? -87.291  58.441 35.261  1.00 41.93  ? 922  ALA B C   1 
ATOM   2563 O O   . ALA B 1 72  ? -88.173  57.579 35.277  1.00 40.70  ? 922  ALA B O   1 
ATOM   2564 C CB  . ALA B 1 72  ? -85.214  57.928 33.968  1.00 41.79  ? 922  ALA B CB  1 
ATOM   2565 N N   . THR B 1 73  ? -87.544  59.738 35.205  1.00 34.67  ? 923  THR B N   1 
ATOM   2566 C CA  . THR B 1 73  ? -88.926  60.228 35.045  1.00 36.19  ? 923  THR B CA  1 
ATOM   2567 C C   . THR B 1 73  ? -89.041  60.818 33.638  1.00 34.44  ? 923  THR B C   1 
ATOM   2568 O O   . THR B 1 73  ? -88.443  61.857 33.380  1.00 32.31  ? 923  THR B O   1 
ATOM   2569 C CB  . THR B 1 73  ? -89.326  61.176 36.181  1.00 31.17  ? 923  THR B CB  1 
ATOM   2570 O OG1 . THR B 1 73  ? -89.072  60.534 37.427  1.00 35.36  ? 923  THR B OG1 1 
ATOM   2571 C CG2 . THR B 1 73  ? -90.771  61.613 36.087  1.00 37.48  ? 923  THR B CG2 1 
ATOM   2572 N N   . ILE B 1 74  ? -89.763  60.114 32.787  1.00 35.43  ? 924  ILE B N   1 
ATOM   2573 C CA  . ILE B 1 74  ? -89.970  60.566 31.392  1.00 42.08  ? 924  ILE B CA  1 
ATOM   2574 C C   . ILE B 1 74  ? -91.320  61.254 31.357  1.00 46.45  ? 924  ILE B C   1 
ATOM   2575 O O   . ILE B 1 74  ? -92.301  60.626 31.714  1.00 49.53  ? 924  ILE B O   1 
ATOM   2576 C CB  . ILE B 1 74  ? -89.926  59.388 30.399  1.00 47.13  ? 924  ILE B CB  1 
ATOM   2577 C CG1 . ILE B 1 74  ? -88.585  58.656 30.449  1.00 50.57  ? 924  ILE B CG1 1 
ATOM   2578 C CG2 . ILE B 1 74  ? -90.252  59.868 28.997  1.00 49.17  ? 924  ILE B CG2 1 
ATOM   2579 C CD1 . ILE B 1 74  ? -87.408  59.536 30.130  1.00 45.58  ? 924  ILE B CD1 1 
ATOM   2580 N N   . LEU B 1 75  ? -91.339  62.493 30.920  1.00 41.75  ? 925  LEU B N   1 
ATOM   2581 C CA  . LEU B 1 75  ? -92.616  63.224 30.954  1.00 50.90  ? 925  LEU B CA  1 
ATOM   2582 C C   . LEU B 1 75  ? -93.578  62.607 29.935  1.00 57.92  ? 925  LEU B C   1 
ATOM   2583 O O   . LEU B 1 75  ? -93.123  62.098 28.902  1.00 48.76  ? 925  LEU B O   1 
ATOM   2584 C CB  . LEU B 1 75  ? -92.366  64.700 30.659  1.00 49.38  ? 925  LEU B CB  1 
ATOM   2585 C CG  . LEU B 1 75  ? -91.547  65.463 31.695  1.00 50.73  ? 925  LEU B CG  1 
ATOM   2586 C CD1 . LEU B 1 75  ? -92.152  66.832 31.939  1.00 51.79  ? 925  LEU B CD1 1 
ATOM   2587 C CD2 . LEU B 1 75  ? -91.444  64.692 32.998  1.00 48.55  ? 925  LEU B CD2 1 
ATOM   2588 N N   . PRO B 1 76  ? -94.889  62.594 30.212  1.00 56.93  ? 926  PRO B N   1 
ATOM   2589 C CA  . PRO B 1 76  ? -95.840  62.126 29.233  1.00 57.60  ? 926  PRO B CA  1 
ATOM   2590 C C   . PRO B 1 76  ? -96.020  63.176 28.125  1.00 52.91  ? 926  PRO B C   1 
ATOM   2591 O O   . PRO B 1 76  ? -95.591  64.291 28.280  1.00 46.92  ? 926  PRO B O   1 
ATOM   2592 C CB  . PRO B 1 76  ? -97.102  61.932 30.083  1.00 61.00  ? 926  PRO B CB  1 
ATOM   2593 C CG  . PRO B 1 76  ? -96.639  61.994 31.515  1.00 57.68  ? 926  PRO B CG  1 
ATOM   2594 C CD  . PRO B 1 76  ? -95.488  62.967 31.480  1.00 54.99  ? 926  PRO B CD  1 
ATOM   2595 N N   . LYS B 1 77  ? -96.746  62.755 27.072  1.00 59.10  ? 927  LYS B N   1 
ATOM   2596 C CA  . LYS B 1 77  ? -97.125  63.667 25.967  1.00 59.58  ? 927  LYS B CA  1 
ATOM   2597 C C   . LYS B 1 77  ? -97.931  64.817 26.560  1.00 55.50  ? 927  LYS B C   1 
ATOM   2598 O O   . LYS B 1 77  ? -97.779  65.935 26.076  1.00 59.06  ? 927  LYS B O   1 
ATOM   2599 C CB  . LYS B 1 77  ? -98.012  62.920 24.972  1.00 64.82  ? 927  LYS B CB  1 
ATOM   2600 C CG  . LYS B 1 77  ? -97.552  61.518 24.598  1.00 70.84  ? 927  LYS B CG  1 
ATOM   2601 C CD  . LYS B 1 77  ? -98.550  60.753 23.745  1.00 76.48  ? 927  LYS B CD  1 
ATOM   2602 C CE  . LYS B 1 77  ? -98.935  61.477 22.472  1.00 77.38  ? 927  LYS B CE  1 
ATOM   2603 N NZ  . LYS B 1 77  ? -99.790  60.641 21.596  1.00 82.73  ? 927  LYS B NZ  1 
ATOM   2604 N N   . THR B 1 78  ? -98.753  64.539 27.568  1.00 57.49  ? 928  THR B N   1 
ATOM   2605 C CA  . THR B 1 78  ? -99.444  65.633 28.289  1.00 51.30  ? 928  THR B CA  1 
ATOM   2606 C C   . THR B 1 78  ? -98.461  66.748 28.646  1.00 53.44  ? 928  THR B C   1 
ATOM   2607 O O   . THR B 1 78  ? -98.890  67.896 28.681  1.00 53.67  ? 928  THR B O   1 
ATOM   2608 C CB  . THR B 1 78  ? -100.048 65.063 29.566  1.00 56.72  ? 928  THR B CB  1 
ATOM   2609 O OG1 . THR B 1 78  ? -98.984  64.685 30.436  1.00 59.75  ? 928  THR B OG1 1 
ATOM   2610 C CG2 . THR B 1 78  ? -100.927 63.863 29.302  1.00 65.96  ? 928  THR B CG2 1 
ATOM   2611 N N   . GLY B 1 79  ? -97.194  66.408 28.906  1.00 51.35  ? 929  GLY B N   1 
ATOM   2612 C CA  . GLY B 1 79  ? -96.165  67.405 29.275  1.00 45.59  ? 929  GLY B CA  1 
ATOM   2613 C C   . GLY B 1 79  ? -96.263  67.790 30.740  1.00 38.41  ? 929  GLY B C   1 
ATOM   2614 O O   . GLY B 1 79  ? -95.699  68.809 31.096  1.00 39.49  ? 929  GLY B O   1 
ATOM   2615 N N   . THR B 1 80  ? -96.971  66.978 31.530  1.00 44.68  ? 930  THR B N   1 
ATOM   2616 C CA  . THR B 1 80  ? -97.174  67.234 32.980  1.00 44.35  ? 930  THR B CA  1 
ATOM   2617 C C   . THR B 1 80  ? -96.599  66.103 33.832  1.00 44.53  ? 930  THR B C   1 
ATOM   2618 O O   . THR B 1 80  ? -96.476  64.999 33.321  1.00 44.43  ? 930  THR B O   1 
ATOM   2619 C CB  . THR B 1 80  ? -98.659  67.340 33.339  1.00 41.58  ? 930  THR B CB  1 
ATOM   2620 O OG1 . THR B 1 80  ? -99.304  66.135 32.941  1.00 42.68  ? 930  THR B OG1 1 
ATOM   2621 C CG2 . THR B 1 80  ? -99.315  68.530 32.678  1.00 47.72  ? 930  THR B CG2 1 
ATOM   2622 N N   . VAL B 1 81  ? -96.285  66.389 35.089  1.00 38.87  ? 931  VAL B N   1 
ATOM   2623 C CA  . VAL B 1 81  ? -95.787  65.354 36.043  1.00 37.46  ? 931  VAL B CA  1 
ATOM   2624 C C   . VAL B 1 81  ? -96.008  65.878 37.461  1.00 28.12  ? 931  VAL B C   1 
ATOM   2625 O O   . VAL B 1 81  ? -95.870  67.059 37.692  1.00 33.74  ? 931  VAL B O   1 
ATOM   2626 C CB  . VAL B 1 81  ? -94.310  64.972 35.824  1.00 34.73  ? 931  VAL B CB  1 
ATOM   2627 C CG1 . VAL B 1 81  ? -93.382  66.153 36.046  1.00 40.83  ? 931  VAL B CG1 1 
ATOM   2628 C CG2 . VAL B 1 81  ? -93.891  63.800 36.692  1.00 42.47  ? 931  VAL B CG2 1 
ATOM   2629 N N   . SER B 1 82  ? -96.358  64.962 38.340  1.00 34.05  ? 932  SER B N   1 
ATOM   2630 C CA  A SER B 1 82  ? -96.562  65.347 39.731  0.32 32.29  ? 932  SER B CA  1 
ATOM   2631 C CA  B SER B 1 82  ? -96.570  65.344 39.731  0.68 32.30  ? 932  SER B CA  1 
ATOM   2632 C C   . SER B 1 82  ? -95.531  64.634 40.589  1.00 25.75  ? 932  SER B C   1 
ATOM   2633 O O   . SER B 1 82  ? -95.530  63.401 40.671  1.00 29.49  ? 932  SER B O   1 
ATOM   2634 C CB  A SER B 1 82  ? -97.980  65.020 40.199  0.32 35.57  ? 932  SER B CB  1 
ATOM   2635 C CB  B SER B 1 82  ? -97.991  64.996 40.179  0.68 35.67  ? 932  SER B CB  1 
ATOM   2636 O OG  A SER B 1 82  ? -98.912  65.920 39.627  0.32 31.32  ? 932  SER B OG  1 
ATOM   2637 O OG  B SER B 1 82  ? -98.230  65.393 41.517  0.68 32.84  ? 932  SER B OG  1 
ATOM   2638 N N   . LEU B 1 83  ? -94.650  65.407 41.221  1.00 26.45  ? 933  LEU B N   1 
ATOM   2639 C CA  . LEU B 1 83  ? -93.557  64.845 42.005  1.00 25.33  ? 933  LEU B CA  1 
ATOM   2640 C C   . LEU B 1 83  ? -93.757  65.216 43.465  1.00 23.99  ? 933  LEU B C   1 
ATOM   2641 O O   . LEU B 1 83  ? -93.872  66.398 43.794  1.00 27.29  ? 933  LEU B O   1 
ATOM   2642 C CB  . LEU B 1 83  ? -92.214  65.365 41.492  1.00 25.57  ? 933  LEU B CB  1 
ATOM   2643 C CG  . LEU B 1 83  ? -91.846  64.889 40.087  1.00 27.33  ? 933  LEU B CG  1 
ATOM   2644 C CD1 . LEU B 1 83  ? -90.575  65.578 39.632  1.00 28.31  ? 933  LEU B CD1 1 
ATOM   2645 C CD2 . LEU B 1 83  ? -91.690  63.375 40.042  1.00 30.74  ? 933  LEU B CD2 1 
ATOM   2646 N N   . GLU B 1 84  ? -93.784  64.220 44.340  1.00 23.40  ? 934  GLU B N   1 
ATOM   2647 C CA  . GLU B 1 84  ? -93.967  64.469 45.762  1.00 24.03  ? 934  GLU B CA  1 
ATOM   2648 C C   . GLU B 1 84  ? -92.636  64.315 46.481  1.00 24.92  ? 934  GLU B C   1 
ATOM   2649 O O   . GLU B 1 84  ? -91.898  63.362 46.228  1.00 23.95  ? 934  GLU B O   1 
ATOM   2650 C CB  . GLU B 1 84  ? -95.006  63.525 46.365  1.00 26.48  ? 934  GLU B CB  1 
ATOM   2651 C CG  . GLU B 1 84  ? -95.024  63.590 47.882  1.00 24.74  ? 934  GLU B CG  1 
ATOM   2652 C CD  . GLU B 1 84  ? -96.167  62.827 48.489  1.00 32.29  ? 934  GLU B CD  1 
ATOM   2653 O OE1 . GLU B 1 84  ? -97.256  62.815 47.879  1.00 37.42  ? 934  GLU B OE1 1 
ATOM   2654 O OE2 . GLU B 1 84  ? -95.972  62.243 49.573  1.00 33.30  ? 934  GLU B OE2 1 
ATOM   2655 N N   . VAL B 1 85  ? -92.322  65.263 47.357  1.00 22.27  ? 935  VAL B N   1 
ATOM   2656 C CA  . VAL B 1 85  ? -91.158  65.198 48.228  1.00 24.36  ? 935  VAL B CA  1 
ATOM   2657 C C   . VAL B 1 85  ? -91.656  64.989 49.650  1.00 24.61  ? 935  VAL B C   1 
ATOM   2658 O O   . VAL B 1 85  ? -92.566  65.693 50.104  1.00 27.02  ? 935  VAL B O   1 
ATOM   2659 C CB  . VAL B 1 85  ? -90.306  66.477 48.140  1.00 24.32  ? 935  VAL B CB  1 
ATOM   2660 C CG1 . VAL B 1 85  ? -89.119  66.389 49.099  1.00 23.89  ? 935  VAL B CG1 1 
ATOM   2661 C CG2 . VAL B 1 85  ? -89.864  66.748 46.705  1.00 24.28  ? 935  VAL B CG2 1 
ATOM   2662 N N   . ARG B 1 86  ? -91.078  64.014 50.343  1.00 23.78  ? 936  ARG B N   1 
ATOM   2663 C CA  . ARG B 1 86  ? -91.347  63.772 51.753  1.00 22.84  ? 936  ARG B CA  1 
ATOM   2664 C C   . ARG B 1 86  ? -90.049  63.905 52.536  1.00 25.87  ? 936  ARG B C   1 
ATOM   2665 O O   . ARG B 1 86  ? -89.011  63.385 52.117  1.00 25.30  ? 936  ARG B O   1 
ATOM   2666 C CB  . ARG B 1 86  ? -91.946  62.379 51.984  1.00 23.72  ? 936  ARG B CB  1 
ATOM   2667 C CG  . ARG B 1 86  ? -93.343  62.176 51.417  1.00 26.05  ? 936  ARG B CG  1 
ATOM   2668 C CD  . ARG B 1 86  ? -93.846  60.754 51.672  1.00 25.67  ? 936  ARG B CD  1 
ATOM   2669 N NE  . ARG B 1 86  ? -93.047  59.742 50.988  1.00 27.83  ? 936  ARG B NE  1 
ATOM   2670 C CZ  . ARG B 1 86  ? -93.234  59.358 49.732  1.00 29.46  ? 936  ARG B CZ  1 
ATOM   2671 N NH1 . ARG B 1 86  ? -94.200  59.873 48.988  1.00 29.24  ? 936  ARG B NH1 1 
ATOM   2672 N NH2 . ARG B 1 86  ? -92.431  58.436 49.208  1.00 29.26  ? 936  ARG B NH2 1 
ATOM   2673 N N   . LEU B 1 87  ? -90.104  64.607 53.665  1.00 25.92  ? 937  LEU B N   1 
ATOM   2674 C CA  . LEU B 1 87  ? -88.984  64.673 54.596  1.00 22.38  ? 937  LEU B CA  1 
ATOM   2675 C C   . LEU B 1 87  ? -89.299  63.738 55.758  1.00 26.76  ? 937  LEU B C   1 
ATOM   2676 O O   . LEU B 1 87  ? -90.334  63.896 56.413  1.00 26.56  ? 937  LEU B O   1 
ATOM   2677 C CB  . LEU B 1 87  ? -88.771  66.107 55.084  1.00 25.03  ? 937  LEU B CB  1 
ATOM   2678 C CG  . LEU B 1 87  ? -88.457  67.149 54.001  1.00 26.01  ? 937  LEU B CG  1 
ATOM   2679 C CD1 . LEU B 1 87  ? -88.185  68.526 54.608  1.00 27.48  ? 937  LEU B CD1 1 
ATOM   2680 C CD2 . LEU B 1 87  ? -87.308  66.708 53.098  1.00 27.78  ? 937  LEU B CD2 1 
ATOM   2681 N N   . LEU B 1 88  ? -88.429  62.760 56.007  1.00 23.30  ? 938  LEU B N   1 
ATOM   2682 C CA  . LEU B 1 88  ? -88.743  61.766 57.025  1.00 24.53  ? 938  LEU B CA  1 
ATOM   2683 C C   . LEU B 1 88  ? -88.704  62.385 58.421  1.00 27.01  ? 938  LEU B C   1 
ATOM   2684 O O   . LEU B 1 88  ? -87.935  63.309 58.697  1.00 26.45  ? 938  LEU B O   1 
ATOM   2685 C CB  . LEU B 1 88  ? -87.786  60.572 56.944  1.00 25.63  ? 938  LEU B CB  1 
ATOM   2686 C CG  . LEU B 1 88  ? -88.117  59.474 55.920  1.00 25.88  ? 938  LEU B CG  1 
ATOM   2687 C CD1 . LEU B 1 88  ? -87.959  59.943 54.470  1.00 24.56  ? 938  LEU B CD1 1 
ATOM   2688 C CD2 . LEU B 1 88  ? -87.312  58.204 56.178  1.00 33.77  ? 938  LEU B CD2 1 
ATOM   2689 N N   . GLU B 1 89  ? -89.558  61.862 59.300  1.00 27.12  ? 939  GLU B N   1 
ATOM   2690 C CA  . GLU B 1 89  ? -89.672  62.368 60.663  1.00 24.40  ? 939  GLU B CA  1 
ATOM   2691 C C   . GLU B 1 89  ? -88.352  62.238 61.414  1.00 25.59  ? 939  GLU B C   1 
ATOM   2692 O O   . GLU B 1 89  ? -87.712  61.182 61.383  1.00 29.10  ? 939  GLU B O   1 
ATOM   2693 C CB  . GLU B 1 89  ? -90.765  61.596 61.402  1.00 27.81  ? 939  GLU B CB  1 
ATOM   2694 C CG  . GLU B 1 89  ? -91.021  62.041 62.829  1.00 28.20  ? 939  GLU B CG  1 
ATOM   2695 C CD  . GLU B 1 89  ? -91.919  61.070 63.573  1.00 34.91  ? 939  GLU B CD  1 
ATOM   2696 O OE1 . GLU B 1 89  ? -91.532  59.890 63.713  1.00 30.79  ? 939  GLU B OE1 1 
ATOM   2697 O OE2 . GLU B 1 89  ? -92.996  61.492 64.040  1.00 35.55  ? 939  GLU B OE2 1 
ATOM   2698 N N   . ALA B 1 90  ? -87.954  63.316 62.096  1.00 25.52  ? 940  ALA B N   1 
ATOM   2699 C CA  . ALA B 1 90  ? -86.799  63.313 63.002  1.00 30.45  ? 940  ALA B CA  1 
ATOM   2700 C C   . ALA B 1 90  ? -85.548  62.771 62.316  1.00 29.13  ? 940  ALA B C   1 
ATOM   2701 O O   . ALA B 1 90  ? -84.780  61.995 62.891  1.00 28.01  ? 940  ALA B O   1 
ATOM   2702 C CB  . ALA B 1 90  ? -87.108  62.525 64.275  1.00 30.75  ? 940  ALA B CB  1 
ATOM   2703 N N   . SER B 1 91  ? -85.346  63.187 61.069  1.00 27.96  ? 941  SER B N   1 
ATOM   2704 C CA  . SER B 1 91  ? -84.304  62.631 60.220  1.00 28.32  ? 941  SER B CA  1 
ATOM   2705 C C   . SER B 1 91  ? -83.982  63.642 59.129  1.00 30.58  ? 941  SER B C   1 
ATOM   2706 O O   . SER B 1 91  ? -84.783  64.532 58.828  1.00 27.10  ? 941  SER B O   1 
ATOM   2707 C CB  . SER B 1 91  ? -84.741  61.288 59.619  1.00 29.05  ? 941  SER B CB  1 
ATOM   2708 O OG  . SER B 1 91  ? -83.838  60.823 58.631  1.00 30.17  ? 941  SER B OG  1 
ATOM   2709 N N   . ARG B 1 92  ? -82.789  63.502 58.551  1.00 25.72  ? 942  ARG B N   1 
ATOM   2710 C CA  . ARG B 1 92  ? -82.411  64.249 57.358  1.00 27.35  ? 942  ARG B CA  1 
ATOM   2711 C C   . ARG B 1 92  ? -82.831  63.551 56.077  1.00 26.28  ? 942  ARG B C   1 
ATOM   2712 O O   . ARG B 1 92  ? -82.667  64.122 54.993  1.00 26.50  ? 942  ARG B O   1 
ATOM   2713 C CB  . ARG B 1 92  ? -80.895  64.459 57.301  1.00 27.86  ? 942  ARG B CB  1 
ATOM   2714 C CG  . ARG B 1 92  ? -80.333  65.395 58.337  1.00 29.79  ? 942  ARG B CG  1 
ATOM   2715 C CD  . ARG B 1 92  ? -78.817  65.293 58.379  1.00 25.81  ? 942  ARG B CD  1 
ATOM   2716 N NE  . ARG B 1 92  ? -78.245  66.315 59.245  1.00 29.41  ? 942  ARG B NE  1 
ATOM   2717 C CZ  . ARG B 1 92  ? -76.953  66.432 59.522  1.00 27.96  ? 942  ARG B CZ  1 
ATOM   2718 N NH1 . ARG B 1 92  ? -76.063  65.579 59.044  1.00 33.38  ? 942  ARG B NH1 1 
ATOM   2719 N NH2 . ARG B 1 92  ? -76.548  67.422 60.312  1.00 32.03  ? 942  ARG B NH2 1 
ATOM   2720 N N   . ALA B 1 93  ? -83.349  62.332 56.172  1.00 24.44  ? 943  ALA B N   1 
ATOM   2721 C CA  . ALA B 1 93  ? -83.674  61.573 54.978  1.00 24.08  ? 943  ALA B CA  1 
ATOM   2722 C C   . ALA B 1 93  ? -84.854  62.197 54.242  1.00 25.46  ? 943  ALA B C   1 
ATOM   2723 O O   . ALA B 1 93  ? -85.748  62.803 54.841  1.00 26.58  ? 943  ALA B O   1 
ATOM   2724 C CB  . ALA B 1 93  ? -83.982  60.120 55.338  1.00 28.80  ? 943  ALA B CB  1 
ATOM   2725 N N   . PHE B 1 94  ? -84.837  62.052 52.919  1.00 24.00  ? 944  PHE B N   1 
ATOM   2726 C CA  . PHE B 1 94  ? -85.919  62.522 52.071  1.00 26.94  ? 944  PHE B CA  1 
ATOM   2727 C C   . PHE B 1 94  ? -86.249  61.450 51.043  1.00 26.18  ? 944  PHE B C   1 
ATOM   2728 O O   . PHE B 1 94  ? -85.449  60.551 50.767  1.00 26.08  ? 944  PHE B O   1 
ATOM   2729 C CB  . PHE B 1 94  ? -85.566  63.847 51.372  1.00 26.88  ? 944  PHE B CB  1 
ATOM   2730 C CG  . PHE B 1 94  ? -84.538  63.711 50.276  1.00 25.24  ? 944  PHE B CG  1 
ATOM   2731 C CD1 . PHE B 1 94  ? -84.916  63.394 48.978  1.00 24.37  ? 944  PHE B CD1 1 
ATOM   2732 C CD2 . PHE B 1 94  ? -83.195  63.918 50.542  1.00 26.30  ? 944  PHE B CD2 1 
ATOM   2733 C CE1 . PHE B 1 94  ? -83.974  63.268 47.974  1.00 25.86  ? 944  PHE B CE1 1 
ATOM   2734 C CE2 . PHE B 1 94  ? -82.248  63.799 49.538  1.00 25.02  ? 944  PHE B CE2 1 
ATOM   2735 C CZ  . PHE B 1 94  ? -82.639  63.474 48.254  1.00 25.18  ? 944  PHE B CZ  1 
ATOM   2736 N N   . GLU B 1 95  ? -87.449  61.558 50.481  1.00 23.76  ? 945  GLU B N   1 
ATOM   2737 C CA  . GLU B 1 95  ? -87.883  60.719 49.374  1.00 23.91  ? 945  GLU B CA  1 
ATOM   2738 C C   . GLU B 1 95  ? -88.564  61.600 48.339  1.00 25.39  ? 945  GLU B C   1 
ATOM   2739 O O   . GLU B 1 95  ? -89.227  62.577 48.691  1.00 23.48  ? 945  GLU B O   1 
ATOM   2740 C CB  . GLU B 1 95  ? -88.852  59.610 49.829  1.00 28.25  ? 945  GLU B CB  1 
ATOM   2741 C CG  . GLU B 1 95  ? -88.259  58.627 50.834  1.00 28.08  ? 945  GLU B CG  1 
ATOM   2742 C CD  . GLU B 1 95  ? -89.306  57.767 51.535  1.00 33.04  ? 945  GLU B CD  1 
ATOM   2743 O OE1 . GLU B 1 95  ? -90.517  57.950 51.286  1.00 29.13  ? 945  GLU B OE1 1 
ATOM   2744 O OE2 . GLU B 1 95  ? -88.908  56.918 52.362  1.00 30.97  ? 945  GLU B OE2 1 
ATOM   2745 N N   . VAL B 1 96  ? -88.386  61.263 47.066  1.00 23.33  ? 946  VAL B N   1 
ATOM   2746 C CA  . VAL B 1 96  ? -89.155  61.849 45.974  1.00 23.42  ? 946  VAL B CA  1 
ATOM   2747 C C   . VAL B 1 96  ? -89.889  60.707 45.298  1.00 27.87  ? 946  VAL B C   1 
ATOM   2748 O O   . VAL B 1 96  ? -89.289  59.669 45.016  1.00 25.86  ? 946  VAL B O   1 
ATOM   2749 C CB  . VAL B 1 96  ? -88.265  62.593 44.962  1.00 22.90  ? 946  VAL B CB  1 
ATOM   2750 C CG1 . VAL B 1 96  ? -89.119  63.190 43.847  1.00 23.79  ? 946  VAL B CG1 1 
ATOM   2751 C CG2 . VAL B 1 96  ? -87.456  63.664 45.655  1.00 25.56  ? 946  VAL B CG2 1 
ATOM   2752 N N   . SER B 1 97  ? -91.181  60.874 45.072  1.00 24.22  ? 947  SER B N   1 
ATOM   2753 C CA  . SER B 1 97  ? -91.962  59.816 44.460  1.00 26.37  ? 947  SER B CA  1 
ATOM   2754 C C   . SER B 1 97  ? -92.833  60.378 43.349  1.00 27.69  ? 947  SER B C   1 
ATOM   2755 O O   . SER B 1 97  ? -93.138  61.574 43.297  1.00 24.64  ? 947  SER B O   1 
ATOM   2756 C CB  . SER B 1 97  ? -92.824  59.073 45.494  1.00 27.90  ? 947  SER B CB  1 
ATOM   2757 O OG  . SER B 1 97  ? -93.739  59.943 46.131  1.00 28.88  ? 947  SER B OG  1 
ATOM   2758 N N   . GLU B 1 98  ? -93.213  59.482 42.447  1.00 24.84  ? 948  GLU B N   1 
ATOM   2759 C CA  . GLU B 1 98  ? -94.179  59.781 41.402  1.00 26.20  ? 948  GLU B CA  1 
ATOM   2760 C C   . GLU B 1 98  ? -95.202  58.662 41.381  1.00 31.42  ? 948  GLU B C   1 
ATOM   2761 O O   . GLU B 1 98  ? -94.842  57.497 41.180  1.00 33.32  ? 948  GLU B O   1 
ATOM   2762 C CB  . GLU B 1 98  ? -93.523  59.905 40.025  1.00 32.58  ? 948  GLU B CB  1 
ATOM   2763 C CG  . GLU B 1 98  ? -94.562  60.055 38.919  1.00 39.89  ? 948  GLU B CG  1 
ATOM   2764 C CD  . GLU B 1 98  ? -94.004  59.858 37.526  1.00 46.81  ? 948  GLU B CD  1 
ATOM   2765 O OE1 . GLU B 1 98  ? -93.264  58.875 37.314  1.00 50.94  ? 948  GLU B OE1 1 
ATOM   2766 O OE2 . GLU B 1 98  ? -94.334  60.665 36.633  1.00 51.51  ? 948  GLU B OE2 1 
ATOM   2767 N N   . ASN B 1 99  ? -96.469  59.017 41.582  1.00 36.82  ? 949  ASN B N   1 
ATOM   2768 C CA  . ASN B 1 99  ? -97.554  58.041 41.620  1.00 40.13  ? 949  ASN B CA  1 
ATOM   2769 C C   . ASN B 1 99  ? -97.270  56.934 42.633  1.00 40.71  ? 949  ASN B C   1 
ATOM   2770 O O   . ASN B 1 99  ? -97.625  55.771 42.430  1.00 45.05  ? 949  ASN B O   1 
ATOM   2771 C CB  . ASN B 1 99  ? -97.777  57.456 40.229  1.00 39.69  ? 949  ASN B CB  1 
ATOM   2772 C CG  . ASN B 1 99  ? -98.470  58.422 39.306  1.00 42.67  ? 949  ASN B CG  1 
ATOM   2773 O OD1 . ASN B 1 99  ? -99.211  59.299 39.747  1.00 50.13  ? 949  ASN B OD1 1 
ATOM   2774 N ND2 . ASN B 1 99  ? -98.195  58.300 38.014  1.00 51.30  ? 949  ASN B ND2 1 
ATOM   2775 N N   . GLY B 1 100 ? -96.633  57.307 43.744  1.00 36.68  ? 950  GLY B N   1 
ATOM   2776 C CA  . GLY B 1 100 ? -96.248  56.378 44.786  1.00 38.71  ? 950  GLY B CA  1 
ATOM   2777 C C   . GLY B 1 100 ? -94.937  55.648 44.569  1.00 41.52  ? 950  GLY B C   1 
ATOM   2778 O O   . GLY B 1 100 ? -94.353  55.161 45.544  1.00 44.09  ? 950  GLY B O   1 
ATOM   2779 N N   . ASN B 1 101 ? -94.412  55.623 43.345  1.00 34.14  ? 951  ASN B N   1 
ATOM   2780 C CA  . ASN B 1 101 ? -93.157  54.935 43.062  1.00 37.18  ? 951  ASN B CA  1 
ATOM   2781 C C   . ASN B 1 101 ? -91.978  55.786 43.508  1.00 32.12  ? 951  ASN B C   1 
ATOM   2782 O O   . ASN B 1 101 ? -91.938  56.990 43.238  1.00 29.53  ? 951  ASN B O   1 
ATOM   2783 C CB  . ASN B 1 101 ? -93.033  54.643 41.569  1.00 37.44  ? 951  ASN B CB  1 
ATOM   2784 C CG  . ASN B 1 101 ? -94.132  53.749 41.059  1.00 48.64  ? 951  ASN B CG  1 
ATOM   2785 O OD1 . ASN B 1 101 ? -94.645  52.901 41.786  1.00 48.71  ? 951  ASN B OD1 1 
ATOM   2786 N ND2 . ASN B 1 101 ? -94.523  53.954 39.808  1.00 52.69  ? 951  ASN B ND2 1 
ATOM   2787 N N   . LEU B 1 102 ? -91.016  55.159 44.181  1.00 32.12  ? 952  LEU B N   1 
ATOM   2788 C CA  . LEU B 1 102 ? -89.846  55.884 44.661  1.00 30.66  ? 952  LEU B CA  1 
ATOM   2789 C C   . LEU B 1 102 ? -88.922  56.236 43.498  1.00 30.81  ? 952  LEU B C   1 
ATOM   2790 O O   . LEU B 1 102 ? -88.510  55.361 42.729  1.00 30.65  ? 952  LEU B O   1 
ATOM   2791 C CB  . LEU B 1 102 ? -89.102  55.053 45.706  1.00 30.24  ? 952  LEU B CB  1 
ATOM   2792 C CG  . LEU B 1 102 ? -87.905  55.732 46.377  1.00 28.99  ? 952  LEU B CG  1 
ATOM   2793 C CD1 . LEU B 1 102 ? -88.382  56.893 47.238  1.00 30.79  ? 952  LEU B CD1 1 
ATOM   2794 C CD2 . LEU B 1 102 ? -87.094  54.744 47.207  1.00 30.82  ? 952  LEU B CD2 1 
ATOM   2795 N N   . VAL B 1 103 ? -88.589  57.520 43.378  1.00 25.27  ? 953  VAL B N   1 
ATOM   2796 C CA  . VAL B 1 103 ? -87.725  58.027 42.325  1.00 24.12  ? 953  VAL B CA  1 
ATOM   2797 C C   . VAL B 1 103 ? -86.351  58.411 42.862  1.00 29.54  ? 953  VAL B C   1 
ATOM   2798 O O   . VAL B 1 103 ? -85.334  58.101 42.239  1.00 27.98  ? 953  VAL B O   1 
ATOM   2799 C CB  . VAL B 1 103 ? -88.389  59.231 41.618  1.00 29.37  ? 953  VAL B CB  1 
ATOM   2800 C CG1 . VAL B 1 103 ? -87.509  59.747 40.483  1.00 28.09  ? 953  VAL B CG1 1 
ATOM   2801 C CG2 . VAL B 1 103 ? -89.775  58.867 41.115  1.00 30.37  ? 953  VAL B CG2 1 
ATOM   2802 N N   . VAL B 1 104 ? -86.299  59.094 44.008  1.00 24.48  ? 954  VAL B N   1 
ATOM   2803 C CA  . VAL B 1 104 ? -85.044  59.545 44.607  1.00 25.82  ? 954  VAL B CA  1 
ATOM   2804 C C   . VAL B 1 104 ? -85.105  59.342 46.114  1.00 28.40  ? 954  VAL B C   1 
ATOM   2805 O O   . VAL B 1 104 ? -86.138  59.591 46.744  1.00 26.29  ? 954  VAL B O   1 
ATOM   2806 C CB  . VAL B 1 104 ? -84.749  61.033 44.307  1.00 27.61  ? 954  VAL B CB  1 
ATOM   2807 C CG1 . VAL B 1 104 ? -83.347  61.409 44.788  1.00 25.92  ? 954  VAL B CG1 1 
ATOM   2808 C CG2 . VAL B 1 104 ? -84.917  61.356 42.831  1.00 29.53  ? 954  VAL B CG2 1 
ATOM   2809 N N   . SER B 1 105 ? -83.979  58.936 46.697  1.00 25.79  ? 955  SER B N   1 
ATOM   2810 C CA  . SER B 1 105 ? -83.793  58.943 48.139  1.00 24.50  ? 955  SER B CA  1 
ATOM   2811 C C   . SER B 1 105 ? -82.420  59.520 48.459  1.00 28.12  ? 955  SER B C   1 
ATOM   2812 O O   . SER B 1 105 ? -81.560  59.666 47.586  1.00 27.13  ? 955  SER B O   1 
ATOM   2813 C CB  . SER B 1 105 ? -83.936  57.539 48.742  1.00 27.69  ? 955  SER B CB  1 
ATOM   2814 O OG  . SER B 1 105 ? -83.007  56.636 48.169  1.00 30.02  ? 955  SER B OG  1 
ATOM   2815 N N   . GLY B 1 106 ? -82.232  59.865 49.727  1.00 26.98  ? 956  GLY B N   1 
ATOM   2816 C CA  . GLY B 1 106 ? -80.994  60.472 50.178  1.00 28.00  ? 956  GLY B CA  1 
ATOM   2817 C C   . GLY B 1 106 ? -81.241  61.270 51.447  1.00 28.91  ? 956  GLY B C   1 
ATOM   2818 O O   . GLY B 1 106 ? -82.275  61.125 52.094  1.00 27.58  ? 956  GLY B O   1 
ATOM   2819 N N   . LYS B 1 107 ? -80.274  62.121 51.772  1.00 25.89  ? 957  LYS B N   1 
ATOM   2820 C CA  . LYS B 1 107 ? -80.344  62.990 52.933  1.00 23.91  ? 957  LYS B CA  1 
ATOM   2821 C C   . LYS B 1 107 ? -80.131  64.424 52.477  1.00 27.55  ? 957  LYS B C   1 
ATOM   2822 O O   . LYS B 1 107 ? -79.398  64.683 51.521  1.00 25.18  ? 957  LYS B O   1 
ATOM   2823 C CB  . LYS B 1 107 ? -79.309  62.606 54.002  1.00 27.80  ? 957  LYS B CB  1 
ATOM   2824 C CG  . LYS B 1 107 ? -79.542  61.217 54.569  1.00 30.20  ? 957  LYS B CG  1 
ATOM   2825 C CD  . LYS B 1 107 ? -78.652  60.906 55.759  1.00 44.61  ? 957  LYS B CD  1 
ATOM   2826 C CE  . LYS B 1 107 ? -77.431  60.107 55.337  1.00 40.82  ? 957  LYS B CE  1 
ATOM   2827 N NZ  . LYS B 1 107 ? -77.780  58.787 54.728  1.00 38.41  ? 957  LYS B NZ  1 
ATOM   2828 N N   . VAL B 1 108 ? -80.789  65.354 53.158  1.00 26.59  ? 958  VAL B N   1 
ATOM   2829 C CA  . VAL B 1 108 ? -80.668  66.773 52.852  1.00 24.57  ? 958  VAL B CA  1 
ATOM   2830 C C   . VAL B 1 108 ? -80.694  67.544 54.163  1.00 29.07  ? 958  VAL B C   1 
ATOM   2831 O O   . VAL B 1 108 ? -81.435  67.189 55.086  1.00 27.52  ? 958  VAL B O   1 
ATOM   2832 C CB  . VAL B 1 108 ? -81.789  67.242 51.894  1.00 25.58  ? 958  VAL B CB  1 
ATOM   2833 C CG1 . VAL B 1 108 ? -83.159  67.217 52.576  1.00 26.99  ? 958  VAL B CG1 1 
ATOM   2834 C CG2 . VAL B 1 108 ? -81.481  68.623 51.346  1.00 26.50  ? 958  VAL B CG2 1 
ATOM   2835 N N   . TYR B 1 109 ? -79.865  68.582 54.262  1.00 24.71  ? 959  TYR B N   1 
ATOM   2836 C CA  . TYR B 1 109 ? -79.875  69.347 55.501  1.00 25.37  ? 959  TYR B CA  1 
ATOM   2837 C C   . TYR B 1 109 ? -79.326  70.752 55.300  1.00 28.48  ? 959  TYR B C   1 
ATOM   2838 O O   . TYR B 1 109 ? -78.499  71.005 54.418  1.00 27.26  ? 959  TYR B O   1 
ATOM   2839 C CB  . TYR B 1 109 ? -79.098  68.625 56.616  1.00 29.53  ? 959  TYR B CB  1 
ATOM   2840 C CG  . TYR B 1 109 ? -77.635  68.292 56.357  1.00 29.38  ? 959  TYR B CG  1 
ATOM   2841 C CD1 . TYR B 1 109 ? -77.270  67.124 55.696  1.00 27.57  ? 959  TYR B CD1 1 
ATOM   2842 C CD2 . TYR B 1 109 ? -76.619  69.108 56.846  1.00 29.05  ? 959  TYR B CD2 1 
ATOM   2843 C CE1 . TYR B 1 109 ? -75.934  66.802 55.487  1.00 30.57  ? 959  TYR B CE1 1 
ATOM   2844 C CE2 . TYR B 1 109 ? -75.279  68.791 56.643  1.00 28.05  ? 959  TYR B CE2 1 
ATOM   2845 C CZ  . TYR B 1 109 ? -74.944  67.637 55.964  1.00 32.72  ? 959  TYR B CZ  1 
ATOM   2846 O OH  . TYR B 1 109 ? -73.620  67.316 55.759  1.00 30.32  ? 959  TYR B OH  1 
ATOM   2847 N N   . GLN B 1 110 ? -79.799  71.654 56.162  1.00 29.03  ? 960  GLN B N   1 
ATOM   2848 C CA  . GLN B 1 110 ? -79.304  73.022 56.212  1.00 29.28  ? 960  GLN B CA  1 
ATOM   2849 C C   . GLN B 1 110 ? -77.819  73.021 56.545  1.00 33.93  ? 960  GLN B C   1 
ATOM   2850 O O   . GLN B 1 110 ? -77.385  72.366 57.496  1.00 32.66  ? 960  GLN B O   1 
ATOM   2851 C CB  . GLN B 1 110 ? -80.090  73.807 57.265  1.00 33.23  ? 960  GLN B CB  1 
ATOM   2852 C CG  . GLN B 1 110 ? -79.780  75.287 57.356  1.00 35.97  ? 960  GLN B CG  1 
ATOM   2853 C CD  . GLN B 1 110 ? -80.676  75.998 58.363  1.00 38.91  ? 960  GLN B CD  1 
ATOM   2854 O OE1 . GLN B 1 110 ? -81.212  75.380 59.276  1.00 44.27  ? 960  GLN B OE1 1 
ATOM   2855 N NE2 . GLN B 1 110 ? -80.866  77.293 58.181  1.00 45.82  ? 960  GLN B NE2 1 
ATOM   2856 N N   . TRP B 1 111 ? -77.039  73.758 55.761  1.00 33.04  ? 961  TRP B N   1 
ATOM   2857 C CA  . TRP B 1 111 ? -75.595  73.831 55.952  1.00 34.53  ? 961  TRP B CA  1 
ATOM   2858 C C   . TRP B 1 111 ? -75.283  74.964 56.924  1.00 38.00  ? 961  TRP B C   1 
ATOM   2859 O O   . TRP B 1 111 ? -75.406  76.143 56.576  1.00 37.18  ? 961  TRP B O   1 
ATOM   2860 C CB  . TRP B 1 111 ? -74.899  74.033 54.608  1.00 35.04  ? 961  TRP B CB  1 
ATOM   2861 C CG  . TRP B 1 111 ? -73.403  73.867 54.617  1.00 34.82  ? 961  TRP B CG  1 
ATOM   2862 C CD1 . TRP B 1 111 ? -72.619  73.444 55.653  1.00 38.29  ? 961  TRP B CD1 1 
ATOM   2863 C CD2 . TRP B 1 111 ? -72.519  74.107 53.517  1.00 32.01  ? 961  TRP B CD2 1 
ATOM   2864 N NE1 . TRP B 1 111 ? -71.299  73.416 55.265  1.00 39.60  ? 961  TRP B NE1 1 
ATOM   2865 C CE2 . TRP B 1 111 ? -71.212  73.818 53.958  1.00 37.52  ? 961  TRP B CE2 1 
ATOM   2866 C CE3 . TRP B 1 111 ? -72.706  74.542 52.202  1.00 35.64  ? 961  TRP B CE3 1 
ATOM   2867 C CZ2 . TRP B 1 111 ? -70.099  73.952 53.128  1.00 38.19  ? 961  TRP B CZ2 1 
ATOM   2868 C CZ3 . TRP B 1 111 ? -71.602  74.674 51.381  1.00 37.70  ? 961  TRP B CZ3 1 
ATOM   2869 C CH2 . TRP B 1 111 ? -70.315  74.380 51.847  1.00 34.78  ? 961  TRP B CH2 1 
ATOM   2870 N N   . ASP B 1 112 ? -74.913  74.607 58.152  1.00 35.99  ? 962  ASP B N   1 
ATOM   2871 C CA  . ASP B 1 112 ? -74.584  75.598 59.166  1.00 43.86  ? 962  ASP B CA  1 
ATOM   2872 C C   . ASP B 1 112 ? -73.166  76.102 58.932  1.00 45.77  ? 962  ASP B C   1 
ATOM   2873 O O   . ASP B 1 112 ? -72.244  75.304 58.736  1.00 48.51  ? 962  ASP B O   1 
ATOM   2874 C CB  . ASP B 1 112 ? -74.700  75.002 60.568  1.00 46.01  ? 962  ASP B CB  1 
ATOM   2875 C CG  . ASP B 1 112 ? -76.132  74.689 60.962  1.00 49.55  ? 962  ASP B CG  1 
ATOM   2876 O OD1 . ASP B 1 112 ? -77.063  75.337 60.441  1.00 49.55  ? 962  ASP B OD1 1 
ATOM   2877 O OD2 . ASP B 1 112 ? -76.324  73.787 61.804  1.00 54.69  ? 962  ASP B OD2 1 
ATOM   2878 N N   . ASP B 1 113 ? -72.993  77.422 58.964  1.00 48.93  ? 963  ASP B N   1 
ATOM   2879 C CA  . ASP B 1 113 ? -71.714  78.068 58.683  1.00 55.33  ? 963  ASP B CA  1 
ATOM   2880 C C   . ASP B 1 113 ? -71.013  77.465 57.469  1.00 47.21  ? 963  ASP B C   1 
ATOM   2881 O O   . ASP B 1 113 ? -70.012  76.751 57.623  1.00 43.86  ? 963  ASP B O   1 
ATOM   2882 C CB  . ASP B 1 113 ? -70.801  77.978 59.907  1.00 54.63  ? 963  ASP B CB  1 
ATOM   2883 C CG  . ASP B 1 113 ? -69.823  79.132 59.991  1.00 62.06  ? 963  ASP B CG  1 
ATOM   2884 O OD1 . ASP B 1 113 ? -69.870  80.019 59.114  1.00 59.97  ? 963  ASP B OD1 1 
ATOM   2885 O OD2 . ASP B 1 113 ? -69.001  79.147 60.932  1.00 73.28  ? 963  ASP B OD2 1 
ATOM   2886 N N   . PRO B 1 114 ? -71.506  77.724 56.258  1.00 41.27  ? 964  PRO B N   1 
ATOM   2887 C CA  . PRO B 1 114 ? -70.842  77.195 55.060  1.00 35.73  ? 964  PRO B CA  1 
ATOM   2888 C C   . PRO B 1 114 ? -69.413  77.702 54.980  1.00 39.94  ? 964  PRO B C   1 
ATOM   2889 O O   . PRO B 1 114 ? -69.103  78.812 55.415  1.00 43.82  ? 964  PRO B O   1 
ATOM   2890 C CB  . PRO B 1 114 ? -71.683  77.742 53.902  1.00 35.79  ? 964  PRO B CB  1 
ATOM   2891 C CG  . PRO B 1 114 ? -72.938  78.225 54.494  1.00 43.83  ? 964  PRO B CG  1 
ATOM   2892 C CD  . PRO B 1 114 ? -72.762  78.427 55.956  1.00 42.23  ? 964  PRO B CD  1 
ATOM   2893 N N   . ASP B 1 115 ? -68.529  76.865 54.451  1.00 38.92  ? 965  ASP B N   1 
ATOM   2894 C CA  . ASP B 1 115 ? -67.132  77.258 54.325  1.00 38.11  ? 965  ASP B CA  1 
ATOM   2895 C C   . ASP B 1 115 ? -66.834  77.532 52.856  1.00 34.54  ? 965  ASP B C   1 
ATOM   2896 O O   . ASP B 1 115 ? -66.790  76.590 52.048  1.00 34.27  ? 965  ASP B O   1 
ATOM   2897 C CB  . ASP B 1 115 ? -66.221  76.167 54.902  1.00 40.46  ? 965  ASP B CB  1 
ATOM   2898 C CG  . ASP B 1 115 ? -64.737  76.452 54.717  1.00 46.50  ? 965  ASP B CG  1 
ATOM   2899 O OD1 . ASP B 1 115 ? -64.357  77.596 54.389  1.00 39.51  ? 965  ASP B OD1 1 
ATOM   2900 O OD2 . ASP B 1 115 ? -63.937  75.537 55.007  1.00 41.16  ? 965  ASP B OD2 1 
ATOM   2901 N N   . PRO B 1 116 ? -66.678  78.800 52.457  1.00 38.12  ? 966  PRO B N   1 
ATOM   2902 C CA  . PRO B 1 116 ? -66.462  79.109 51.031  1.00 34.26  ? 966  PRO B CA  1 
ATOM   2903 C C   . PRO B 1 116 ? -65.214  78.470 50.451  1.00 35.88  ? 966  PRO B C   1 
ATOM   2904 O O   . PRO B 1 116 ? -65.129  78.303 49.225  1.00 34.81  ? 966  PRO B O   1 
ATOM   2905 C CB  . PRO B 1 116 ? -66.369  80.643 51.000  1.00 40.48  ? 966  PRO B CB  1 
ATOM   2906 C CG  . PRO B 1 116 ? -66.912  81.122 52.297  1.00 45.54  ? 966  PRO B CG  1 
ATOM   2907 C CD  . PRO B 1 116 ? -66.896  79.999 53.284  1.00 42.21  ? 966  PRO B CD  1 
ATOM   2908 N N   . ARG B 1 117 ? -64.249  78.091 51.291  1.00 34.26  ? 967  ARG B N   1 
ATOM   2909 C CA  . ARG B 1 117 ? -63.035  77.469 50.782  1.00 38.38  ? 967  ARG B CA  1 
ATOM   2910 C C   . ARG B 1 117 ? -63.325  76.152 50.082  1.00 40.05  ? 967  ARG B C   1 
ATOM   2911 O O   . ARG B 1 117 ? -62.519  75.714 49.254  1.00 37.58  ? 967  ARG B O   1 
ATOM   2912 C CB  . ARG B 1 117 ? -62.042  77.255 51.921  1.00 39.82  ? 967  ARG B CB  1 
ATOM   2913 C CG  . ARG B 1 117 ? -61.534  78.555 52.509  1.00 40.79  ? 967  ARG B CG  1 
ATOM   2914 C CD  . ARG B 1 117 ? -60.671  78.316 53.728  1.00 40.11  ? 967  ARG B CD  1 
ATOM   2915 N NE  . ARG B 1 117 ? -61.416  77.650 54.788  1.00 40.80  ? 967  ARG B NE  1 
ATOM   2916 C CZ  . ARG B 1 117 ? -60.909  77.325 55.969  1.00 50.50  ? 967  ARG B CZ  1 
ATOM   2917 N NH1 . ARG B 1 117 ? -59.671  77.652 56.302  1.00 48.58  ? 967  ARG B NH1 1 
ATOM   2918 N NH2 . ARG B 1 117 ? -61.661  76.652 56.835  1.00 41.86  ? 967  ARG B NH2 1 
ATOM   2919 N N   . LEU B 1 118 ? -64.472  75.530 50.366  1.00 36.08  ? 968  LEU B N   1 
ATOM   2920 C CA  . LEU B 1 118 ? -64.820  74.298 49.673  1.00 36.58  ? 968  LEU B CA  1 
ATOM   2921 C C   . LEU B 1 118 ? -64.889  74.509 48.169  1.00 34.97  ? 968  LEU B C   1 
ATOM   2922 O O   . LEU B 1 118 ? -64.631  73.578 47.396  1.00 45.32  ? 968  LEU B O   1 
ATOM   2923 C CB  . LEU B 1 118 ? -66.163  73.771 50.180  1.00 39.97  ? 968  LEU B CB  1 
ATOM   2924 C CG  . LEU B 1 118 ? -66.569  72.433 49.563  1.00 40.16  ? 968  LEU B CG  1 
ATOM   2925 C CD1 . LEU B 1 118 ? -65.604  71.356 50.012  1.00 45.56  ? 968  LEU B CD1 1 
ATOM   2926 C CD2 . LEU B 1 118 ? -68.004  72.064 49.899  1.00 39.04  ? 968  LEU B CD2 1 
ATOM   2927 N N   . PHE B 1 119 ? -65.203  75.726 47.734  1.00 37.96  ? 969  PHE B N   1 
ATOM   2928 C CA  . PHE B 1 119 ? -65.431  76.005 46.326  1.00 40.29  ? 969  PHE B CA  1 
ATOM   2929 C C   . PHE B 1 119 ? -64.209  76.568 45.616  1.00 47.77  ? 969  PHE B C   1 
ATOM   2930 O O   . PHE B 1 119 ? -64.293  76.902 44.431  1.00 46.92  ? 969  PHE B O   1 
ATOM   2931 C CB  . PHE B 1 119 ? -66.599  76.985 46.215  1.00 36.08  ? 969  PHE B CB  1 
ATOM   2932 C CG  . PHE B 1 119 ? -67.846  76.490 46.885  1.00 34.40  ? 969  PHE B CG  1 
ATOM   2933 C CD1 . PHE B 1 119 ? -68.638  75.536 46.274  1.00 37.51  ? 969  PHE B CD1 1 
ATOM   2934 C CD2 . PHE B 1 119 ? -68.192  76.930 48.155  1.00 36.97  ? 969  PHE B CD2 1 
ATOM   2935 C CE1 . PHE B 1 119 ? -69.774  75.056 46.895  1.00 34.13  ? 969  PHE B CE1 1 
ATOM   2936 C CE2 . PHE B 1 119 ? -69.329  76.452 48.784  1.00 36.83  ? 969  PHE B CE2 1 
ATOM   2937 C CZ  . PHE B 1 119 ? -70.122  75.515 48.151  1.00 33.01  ? 969  PHE B CZ  1 
ATOM   2938 N N   . ASP B 1 120 ? -63.081  76.671 46.305  1.00 45.26  ? 970  ASP B N   1 
ATOM   2939 C CA  . ASP B 1 120 ? -61.882  77.267 45.733  1.00 51.33  ? 970  ASP B CA  1 
ATOM   2940 C C   . ASP B 1 120 ? -61.141  76.296 44.819  1.00 55.55  ? 970  ASP B C   1 
ATOM   2941 O O   . ASP B 1 120 ? -60.750  75.202 45.242  1.00 57.84  ? 970  ASP B O   1 
ATOM   2942 C CB  . ASP B 1 120 ? -61.011  77.782 46.868  1.00 47.49  ? 970  ASP B CB  1 
ATOM   2943 C CG  . ASP B 1 120 ? -61.520  79.111 47.397  1.00 43.39  ? 970  ASP B CG  1 
ATOM   2944 O OD1 . ASP B 1 120 ? -62.392  79.710 46.736  1.00 55.14  ? 970  ASP B OD1 1 
ATOM   2945 O OD2 . ASP B 1 120 ? -61.087  79.547 48.480  1.00 51.50  ? 970  ASP B OD2 1 
ATOM   2946 N N   . HIS B 1 121 ? -60.920  76.720 43.577  1.00 63.76  ? 971  HIS B N   1 
ATOM   2947 C CA  . HIS B 1 121 ? -60.326  75.875 42.549  1.00 67.24  ? 971  HIS B CA  1 
ATOM   2948 C C   . HIS B 1 121 ? -58.833  75.665 42.781  1.00 66.28  ? 971  HIS B C   1 
ATOM   2949 O O   . HIS B 1 121 ? -58.262  74.666 42.343  1.00 72.54  ? 971  HIS B O   1 
ATOM   2950 C CB  . HIS B 1 121 ? -60.551  76.486 41.163  1.00 66.02  ? 971  HIS B CB  1 
ATOM   2951 C CG  . HIS B 1 121 ? -61.988  76.771 40.848  1.00 62.79  ? 971  HIS B CG  1 
ATOM   2952 N ND1 . HIS B 1 121 ? -62.405  77.943 40.253  1.00 68.77  ? 971  HIS B ND1 1 
ATOM   2953 C CD2 . HIS B 1 121 ? -63.107  76.038 41.059  1.00 62.52  ? 971  HIS B CD2 1 
ATOM   2954 C CE1 . HIS B 1 121 ? -63.719  77.916 40.106  1.00 62.75  ? 971  HIS B CE1 1 
ATOM   2955 N NE2 . HIS B 1 121 ? -64.168  76.771 40.587  1.00 59.05  ? 971  HIS B NE2 1 
ATOM   2956 N N   . LEU B 1 133 ? -56.190  77.026 22.879  1.00 60.80  ? 983  LEU B N   1 
ATOM   2957 C CA  . LEU B 1 133 ? -57.138  76.222 22.115  1.00 69.58  ? 983  LEU B CA  1 
ATOM   2958 C C   . LEU B 1 133 ? -58.198  75.632 23.046  1.00 69.69  ? 983  LEU B C   1 
ATOM   2959 O O   . LEU B 1 133 ? -57.865  75.003 24.050  1.00 67.91  ? 983  LEU B O   1 
ATOM   2960 C CB  . LEU B 1 133 ? -56.410  75.105 21.362  1.00 72.71  ? 983  LEU B CB  1 
ATOM   2961 C CG  . LEU B 1 133 ? -56.034  75.320 19.891  1.00 77.23  ? 983  LEU B CG  1 
ATOM   2962 C CD1 . LEU B 1 133 ? -55.280  74.109 19.352  1.00 73.41  ? 983  LEU B CD1 1 
ATOM   2963 C CD2 . LEU B 1 133 ? -57.254  75.622 19.034  1.00 72.21  ? 983  LEU B CD2 1 
ATOM   2964 N N   . PHE B 1 134 ? -59.472  75.831 22.709  1.00 65.81  ? 984  PHE B N   1 
ATOM   2965 C CA  . PHE B 1 134 ? -60.573  75.365 23.542  1.00 60.98  ? 984  PHE B CA  1 
ATOM   2966 C C   . PHE B 1 134 ? -61.741  74.956 22.654  1.00 58.23  ? 984  PHE B C   1 
ATOM   2967 O O   . PHE B 1 134 ? -61.737  75.181 21.442  1.00 53.10  ? 984  PHE B O   1 
ATOM   2968 C CB  . PHE B 1 134 ? -61.013  76.430 24.559  1.00 61.30  ? 984  PHE B CB  1 
ATOM   2969 C CG  . PHE B 1 134 ? -61.412  77.745 23.944  1.00 64.05  ? 984  PHE B CG  1 
ATOM   2970 C CD1 . PHE B 1 134 ? -62.696  77.943 23.459  1.00 62.73  ? 984  PHE B CD1 1 
ATOM   2971 C CD2 . PHE B 1 134 ? -60.506  78.790 23.871  1.00 67.89  ? 984  PHE B CD2 1 
ATOM   2972 C CE1 . PHE B 1 134 ? -63.063  79.152 22.901  1.00 65.74  ? 984  PHE B CE1 1 
ATOM   2973 C CE2 . PHE B 1 134 ? -60.868  80.002 23.315  1.00 64.56  ? 984  PHE B CE2 1 
ATOM   2974 C CZ  . PHE B 1 134 ? -62.147  80.184 22.829  1.00 70.37  ? 984  PHE B CZ  1 
ATOM   2975 N N   . LEU B 1 135 ? -62.730  74.310 23.267  1.00 48.85  ? 985  LEU B N   1 
ATOM   2976 C CA  . LEU B 1 135 ? -63.936  73.908 22.558  1.00 49.37  ? 985  LEU B CA  1 
ATOM   2977 C C   . LEU B 1 135 ? -64.991  74.978 22.800  1.00 48.70  ? 985  LEU B C   1 
ATOM   2978 O O   . LEU B 1 135 ? -65.304  75.297 23.951  1.00 49.30  ? 985  LEU B O   1 
ATOM   2979 C CB  . LEU B 1 135 ? -64.437  72.548 23.053  1.00 47.41  ? 985  LEU B CB  1 
ATOM   2980 C CG  . LEU B 1 135 ? -63.589  71.312 22.753  1.00 53.99  ? 985  LEU B CG  1 
ATOM   2981 C CD1 . LEU B 1 135 ? -64.058  70.128 23.582  1.00 55.79  ? 985  LEU B CD1 1 
ATOM   2982 C CD2 . LEU B 1 135 ? -63.663  70.976 21.272  1.00 52.69  ? 985  LEU B CD2 1 
ATOM   2983 N N   . ALA B 1 136 ? -65.568  75.494 21.717  1.00 45.86  ? 986  ALA B N   1 
ATOM   2984 C CA  . ALA B 1 136 ? -66.642  76.464 21.832  1.00 45.92  ? 986  ALA B CA  1 
ATOM   2985 C C   . ALA B 1 136 ? -67.968  75.751 22.077  1.00 37.97  ? 986  ALA B C   1 
ATOM   2986 O O   . ALA B 1 136 ? -68.089  74.536 21.906  1.00 41.64  ? 986  ALA B O   1 
ATOM   2987 C CB  . ALA B 1 136 ? -66.721  77.335 20.578  1.00 45.23  ? 986  ALA B CB  1 
ATOM   2988 N N   . GLN B 1 137 ? -68.978  76.540 22.453  1.00 42.33  ? 987  GLN B N   1 
ATOM   2989 C CA  . GLN B 1 137 ? -70.287  76.000 22.819  1.00 40.89  ? 987  GLN B CA  1 
ATOM   2990 C C   . GLN B 1 137 ? -70.822  75.032 21.764  1.00 43.70  ? 987  GLN B C   1 
ATOM   2991 O O   . GLN B 1 137 ? -71.198  73.892 22.078  1.00 41.38  ? 987  GLN B O   1 
ATOM   2992 C CB  . GLN B 1 137 ? -71.259  77.161 23.052  1.00 43.24  ? 987  GLN B CB  1 
ATOM   2993 C CG  . GLN B 1 137 ? -72.692  76.769 23.366  1.00 43.18  ? 987  GLN B CG  1 
ATOM   2994 C CD  . GLN B 1 137 ? -73.561  77.977 23.675  1.00 48.67  ? 987  GLN B CD  1 
ATOM   2995 O OE1 . GLN B 1 137 ? -73.629  78.432 24.817  1.00 57.06  ? 987  GLN B OE1 1 
ATOM   2996 N NE2 . GLN B 1 137 ? -74.212  78.516 22.650  1.00 60.42  ? 987  GLN B NE2 1 
ATOM   2997 N N   . ALA B 1 138 ? -70.860  75.472 20.502  1.00 40.46  ? 988  ALA B N   1 
ATOM   2998 C CA  . ALA B 1 138 ? -71.430  74.641 19.445  1.00 42.05  ? 988  ALA B CA  1 
ATOM   2999 C C   . ALA B 1 138 ? -70.688  73.316 19.311  1.00 39.21  ? 988  ALA B C   1 
ATOM   3000 O O   . ALA B 1 138 ? -71.311  72.266 19.106  1.00 40.61  ? 988  ALA B O   1 
ATOM   3001 C CB  . ALA B 1 138 ? -71.419  75.401 18.118  1.00 44.52  ? 988  ALA B CB  1 
ATOM   3002 N N   . GLU B 1 139 ? -69.362  73.331 19.472  1.00 42.58  ? 989  GLU B N   1 
ATOM   3003 C CA  . GLU B 1 139 ? -68.602  72.087 19.378  1.00 42.97  ? 989  GLU B CA  1 
ATOM   3004 C C   . GLU B 1 139 ? -68.896  71.178 20.568  1.00 39.16  ? 989  GLU B C   1 
ATOM   3005 O O   . GLU B 1 139 ? -69.005  69.948 20.417  1.00 36.85  ? 989  GLU B O   1 
ATOM   3006 C CB  . GLU B 1 139 ? -67.104  72.387 19.287  1.00 50.91  ? 989  GLU B CB  1 
ATOM   3007 C CG  . GLU B 1 139 ? -66.590  72.669 17.877  1.00 51.35  ? 989  GLU B CG  1 
ATOM   3008 C CD  . GLU B 1 139 ? -67.418  73.707 17.143  1.00 59.74  ? 989  GLU B CD  1 
ATOM   3009 O OE1 . GLU B 1 139 ? -67.651  74.793 17.715  1.00 59.60  ? 989  GLU B OE1 1 
ATOM   3010 O OE2 . GLU B 1 139 ? -67.828  73.443 15.993  1.00 67.62  ? 989  GLU B OE2 1 
ATOM   3011 N N   . VAL B 1 140 ? -69.049  71.772 21.755  1.00 41.36  ? 990  VAL B N   1 
ATOM   3012 C CA  . VAL B 1 140 ? -69.391  71.005 22.949  1.00 35.69  ? 990  VAL B CA  1 
ATOM   3013 C C   . VAL B 1 140 ? -70.693  70.243 22.732  1.00 35.11  ? 990  VAL B C   1 
ATOM   3014 O O   . VAL B 1 140 ? -70.778  69.026 22.966  1.00 34.55  ? 990  VAL B O   1 
ATOM   3015 C CB  . VAL B 1 140 ? -69.481  71.940 24.170  1.00 36.72  ? 990  VAL B CB  1 
ATOM   3016 C CG1 . VAL B 1 140 ? -70.195  71.254 25.326  1.00 36.62  ? 990  VAL B CG1 1 
ATOM   3017 C CG2 . VAL B 1 140 ? -68.093  72.417 24.582  1.00 38.52  ? 990  VAL B CG2 1 
ATOM   3018 N N   . TYR B 1 141 ? -71.710  70.932 22.222  1.00 34.96  ? 991  TYR B N   1 
ATOM   3019 C CA  . TYR B 1 141 ? -73.007  70.278 22.136  1.00 33.60  ? 991  TYR B CA  1 
ATOM   3020 C C   . TYR B 1 141 ? -73.109  69.363 20.924  1.00 37.59  ? 991  TYR B C   1 
ATOM   3021 O O   . TYR B 1 141 ? -73.895  68.410 20.958  1.00 38.45  ? 991  TYR B O   1 
ATOM   3022 C CB  . TYR B 1 141 ? -74.125  71.321 22.222  1.00 36.66  ? 991  TYR B CB  1 
ATOM   3023 C CG  . TYR B 1 141 ? -74.192  71.800 23.651  1.00 38.48  ? 991  TYR B CG  1 
ATOM   3024 C CD1 . TYR B 1 141 ? -74.772  70.999 24.626  1.00 36.24  ? 991  TYR B CD1 1 
ATOM   3025 C CD2 . TYR B 1 141 ? -73.598  72.989 24.048  1.00 36.58  ? 991  TYR B CD2 1 
ATOM   3026 C CE1 . TYR B 1 141 ? -74.806  71.387 25.944  1.00 34.12  ? 991  TYR B CE1 1 
ATOM   3027 C CE2 . TYR B 1 141 ? -73.628  73.390 25.373  1.00 36.96  ? 991  TYR B CE2 1 
ATOM   3028 C CZ  . TYR B 1 141 ? -74.233  72.580 26.316  1.00 38.24  ? 991  TYR B CZ  1 
ATOM   3029 O OH  . TYR B 1 141 ? -74.275  72.961 27.637  1.00 34.72  ? 991  TYR B OH  1 
ATOM   3030 N N   . LYS B 1 142 ? -72.332  69.612 19.867  1.00 39.37  ? 992  LYS B N   1 
ATOM   3031 C CA  . LYS B 1 142 ? -72.176  68.608 18.815  1.00 40.40  ? 992  LYS B CA  1 
ATOM   3032 C C   . LYS B 1 142 ? -71.644  67.285 19.382  1.00 34.88  ? 992  LYS B C   1 
ATOM   3033 O O   . LYS B 1 142 ? -72.172  66.206 19.077  1.00 36.98  ? 992  LYS B O   1 
ATOM   3034 C CB  . LYS B 1 142 ? -71.277  69.157 17.706  1.00 39.89  ? 992  LYS B CB  1 
ATOM   3035 C CG  . LYS B 1 142 ? -71.194  68.281 16.467  1.00 48.73  ? 992  LYS B CG  1 
ATOM   3036 C CD  . LYS B 1 142 ? -70.335  68.943 15.397  1.00 50.12  ? 992  LYS B CD  1 
ATOM   3037 C CE  . LYS B 1 142 ? -69.941  67.967 14.301  1.00 57.16  ? 992  LYS B CE  1 
ATOM   3038 N NZ  . LYS B 1 142 ? -70.920  66.851 14.166  1.00 65.52  ? 992  LYS B NZ  1 
ATOM   3039 N N   . GLU B 1 143 ? -70.572  67.348 20.186  1.00 37.04  ? 993  GLU B N   1 
ATOM   3040 C CA  . GLU B 1 143 ? -69.999  66.130 20.772  1.00 37.11  ? 993  GLU B CA  1 
ATOM   3041 C C   . GLU B 1 143 ? -71.009  65.403 21.662  1.00 35.38  ? 993  GLU B C   1 
ATOM   3042 O O   . GLU B 1 143 ? -71.216  64.173 21.554  1.00 35.97  ? 993  GLU B O   1 
ATOM   3043 C CB  . GLU B 1 143 ? -68.751  66.498 21.575  1.00 38.61  ? 993  GLU B CB  1 
ATOM   3044 C CG  . GLU B 1 143 ? -68.017  65.320 22.176  1.00 42.95  ? 993  GLU B CG  1 
ATOM   3045 C CD  . GLU B 1 143 ? -67.567  64.318 21.138  1.00 52.80  ? 993  GLU B CD  1 
ATOM   3046 O OE1 . GLU B 1 143 ? -67.206  64.735 20.017  1.00 48.68  ? 993  GLU B OE1 1 
ATOM   3047 O OE2 . GLU B 1 143 ? -67.578  63.108 21.444  1.00 53.69  ? 993  GLU B OE2 1 
ATOM   3048 N N   . LEU B 1 144 ? -71.677  66.162 22.530  1.00 34.38  ? 994  LEU B N   1 
ATOM   3049 C CA  . LEU B 1 144 ? -72.636  65.541 23.433  1.00 33.77  ? 994  LEU B CA  1 
ATOM   3050 C C   . LEU B 1 144 ? -73.769  64.889 22.651  1.00 30.09  ? 994  LEU B C   1 
ATOM   3051 O O   . LEU B 1 144 ? -74.175  63.761 22.957  1.00 37.92  ? 994  LEU B O   1 
ATOM   3052 C CB  . LEU B 1 144 ? -73.175  66.583 24.410  1.00 32.87  ? 994  LEU B CB  1 
ATOM   3053 C CG  . LEU B 1 144 ? -72.159  67.000 25.475  1.00 36.84  ? 994  LEU B CG  1 
ATOM   3054 C CD1 . LEU B 1 144 ? -72.706  68.123 26.339  1.00 36.58  ? 994  LEU B CD1 1 
ATOM   3055 C CD2 . LEU B 1 144 ? -71.738  65.812 26.334  1.00 38.90  ? 994  LEU B CD2 1 
ATOM   3056 N N   . ARG B 1 145 ? -74.296  65.587 21.639  1.00 35.53  ? 995  ARG B N   1 
ATOM   3057 C CA  . ARG B 1 145 ? -75.333  65.016 20.785  1.00 35.68  ? 995  ARG B CA  1 
ATOM   3058 C C   . ARG B 1 145 ? -74.866  63.728 20.110  1.00 39.20  ? 995  ARG B C   1 
ATOM   3059 O O   . ARG B 1 145 ? -75.654  62.786 19.951  1.00 39.69  ? 995  ARG B O   1 
ATOM   3060 C CB  . ARG B 1 145 ? -75.789  66.065 19.778  1.00 40.20  ? 995  ARG B CB  1 
ATOM   3061 C CG  . ARG B 1 145 ? -77.072  65.730 19.056  1.00 48.13  ? 995  ARG B CG  1 
ATOM   3062 C CD  . ARG B 1 145 ? -77.479  66.880 18.149  1.00 49.76  ? 995  ARG B CD  1 
ATOM   3063 N NE  . ARG B 1 145 ? -77.128  68.181 18.713  1.00 56.45  ? 995  ARG B NE  1 
ATOM   3064 C CZ  . ARG B 1 145 ? -76.185  68.977 18.225  1.00 51.50  ? 995  ARG B CZ  1 
ATOM   3065 N NH1 . ARG B 1 145 ? -75.476  68.636 17.162  1.00 58.90  ? 995  ARG B NH1 1 
ATOM   3066 N NH2 . ARG B 1 145 ? -75.949  70.145 18.818  1.00 53.48  ? 995  ARG B NH2 1 
ATOM   3067 N N   . LEU B 1 146 ? -73.603  63.681 19.664  1.00 42.14  ? 996  LEU B N   1 
ATOM   3068 C CA  . LEU B 1 146 ? -73.090  62.448 19.067  1.00 41.65  ? 996  LEU B CA  1 
ATOM   3069 C C   . LEU B 1 146 ? -73.193  61.285 20.041  1.00 44.04  ? 996  LEU B C   1 
ATOM   3070 O O   . LEU B 1 146 ? -73.313  60.129 19.616  1.00 45.10  ? 996  LEU B O   1 
ATOM   3071 C CB  . LEU B 1 146 ? -71.645  62.616 18.598  1.00 46.16  ? 996  LEU B CB  1 
ATOM   3072 C CG  . LEU B 1 146 ? -71.428  63.520 17.386  1.00 51.63  ? 996  LEU B CG  1 
ATOM   3073 C CD1 . LEU B 1 146 ? -69.974  63.940 17.267  1.00 51.44  ? 996  LEU B CD1 1 
ATOM   3074 C CD2 . LEU B 1 146 ? -71.894  62.815 16.118  1.00 53.46  ? 996  LEU B CD2 1 
ATOM   3075 N N   . ARG B 1 147 ? -73.057  61.552 21.341  1.00 38.36  ? 997  ARG B N   1 
ATOM   3076 C CA  . ARG B 1 147 ? -73.215  60.468 22.314  1.00 36.78  ? 997  ARG B CA  1 
ATOM   3077 C C   . ARG B 1 147 ? -74.646  60.234 22.806  1.00 38.52  ? 997  ARG B C   1 
ATOM   3078 O O   . ARG B 1 147 ? -74.840  59.390 23.687  1.00 39.63  ? 997  ARG B O   1 
ATOM   3079 C CB  . ARG B 1 147 ? -72.345  60.725 23.531  1.00 41.86  ? 997  ARG B CB  1 
ATOM   3080 C CG  . ARG B 1 147 ? -70.961  61.184 23.214  1.00 40.98  ? 997  ARG B CG  1 
ATOM   3081 C CD  . ARG B 1 147 ? -70.199  61.209 24.501  1.00 43.31  ? 997  ARG B CD  1 
ATOM   3082 N NE  . ARG B 1 147 ? -68.970  61.980 24.423  1.00 45.47  ? 997  ARG B NE  1 
ATOM   3083 C CZ  . ARG B 1 147 ? -68.269  62.342 25.486  1.00 45.69  ? 997  ARG B CZ  1 
ATOM   3084 N NH1 . ARG B 1 147 ? -68.626  61.970 26.704  1.00 48.48  ? 997  ARG B NH1 1 
ATOM   3085 N NH2 . ARG B 1 147 ? -67.165  63.065 25.321  1.00 51.68  ? 997  ARG B NH2 1 
ATOM   3086 N N   . GLY B 1 148 ? -75.644  60.954 22.303  1.00 41.90  ? 998  GLY B N   1 
ATOM   3087 C CA  . GLY B 1 148 ? -77.013  60.698 22.705  1.00 38.83  ? 998  GLY B CA  1 
ATOM   3088 C C   . GLY B 1 148 ? -77.594  61.687 23.695  1.00 39.98  ? 998  GLY B C   1 
ATOM   3089 O O   . GLY B 1 148 ? -78.732  61.491 24.143  1.00 41.12  ? 998  GLY B O   1 
ATOM   3090 N N   . TYR B 1 149 ? -76.859  62.741 24.048  1.00 33.85  ? 999  TYR B N   1 
ATOM   3091 C CA  . TYR B 1 149 ? -77.321  63.752 24.995  1.00 34.80  ? 999  TYR B CA  1 
ATOM   3092 C C   . TYR B 1 149 ? -77.830  64.937 24.182  1.00 38.11  ? 999  TYR B C   1 
ATOM   3093 O O   . TYR B 1 149 ? -77.030  65.674 23.596  1.00 35.74  ? 999  TYR B O   1 
ATOM   3094 C CB  . TYR B 1 149 ? -76.194  64.197 25.931  1.00 34.57  ? 999  TYR B CB  1 
ATOM   3095 C CG  . TYR B 1 149 ? -75.527  63.098 26.728  1.00 40.71  ? 999  TYR B CG  1 
ATOM   3096 C CD1 . TYR B 1 149 ? -74.491  62.344 26.190  1.00 37.34  ? 999  TYR B CD1 1 
ATOM   3097 C CD2 . TYR B 1 149 ? -75.919  62.833 28.033  1.00 39.62  ? 999  TYR B CD2 1 
ATOM   3098 C CE1 . TYR B 1 149 ? -73.880  61.343 26.925  1.00 40.23  ? 999  TYR B CE1 1 
ATOM   3099 C CE2 . TYR B 1 149 ? -75.315  61.837 28.773  1.00 39.98  ? 999  TYR B CE2 1 
ATOM   3100 C CZ  . TYR B 1 149 ? -74.296  61.096 28.216  1.00 46.41  ? 999  TYR B CZ  1 
ATOM   3101 O OH  . TYR B 1 149 ? -73.691  60.103 28.952  1.00 45.37  ? 999  TYR B OH  1 
ATOM   3102 N N   . ASP B 1 150 ? -79.159  65.119 24.125  1.00 34.40  ? 1000 ASP B N   1 
ATOM   3103 C CA  . ASP B 1 150 ? -79.769  66.171 23.316  1.00 38.79  ? 1000 ASP B CA  1 
ATOM   3104 C C   . ASP B 1 150 ? -80.221  67.314 24.223  1.00 42.16  ? 1000 ASP B C   1 
ATOM   3105 O O   . ASP B 1 150 ? -81.273  67.250 24.876  1.00 53.20  ? 1000 ASP B O   1 
ATOM   3106 C CB  . ASP B 1 150 ? -80.938  65.631 22.497  1.00 44.87  ? 1000 ASP B CB  1 
ATOM   3107 C CG  . ASP B 1 150 ? -80.591  64.371 21.739  1.00 52.05  ? 1000 ASP B CG  1 
ATOM   3108 O OD1 . ASP B 1 150 ? -79.522  64.340 21.102  1.00 52.48  ? 1000 ASP B OD1 1 
ATOM   3109 O OD2 . ASP B 1 150 ? -81.415  63.436 21.726  1.00 48.72  ? 1000 ASP B OD2 1 
ATOM   3110 N N   . TYR B 1 151 ? -79.450  68.390 24.222  1.00 37.00  ? 1001 TYR B N   1 
ATOM   3111 C CA  . TYR B 1 151 ? -79.777  69.569 25.006  1.00 34.76  ? 1001 TYR B CA  1 
ATOM   3112 C C   . TYR B 1 151 ? -80.222  70.672 24.059  1.00 38.33  ? 1001 TYR B C   1 
ATOM   3113 O O   . TYR B 1 151 ? -79.508  71.009 23.108  1.00 36.08  ? 1001 TYR B O   1 
ATOM   3114 C CB  . TYR B 1 151 ? -78.591  70.022 25.855  1.00 33.38  ? 1001 TYR B CB  1 
ATOM   3115 C CG  . TYR B 1 151 ? -78.107  68.970 26.826  1.00 34.48  ? 1001 TYR B CG  1 
ATOM   3116 C CD1 . TYR B 1 151 ? -78.866  68.622 27.938  1.00 33.19  ? 1001 TYR B CD1 1 
ATOM   3117 C CD2 . TYR B 1 151 ? -76.889  68.331 26.639  1.00 35.37  ? 1001 TYR B CD2 1 
ATOM   3118 C CE1 . TYR B 1 151 ? -78.427  67.660 28.831  1.00 30.40  ? 1001 TYR B CE1 1 
ATOM   3119 C CE2 . TYR B 1 151 ? -76.442  67.371 27.527  1.00 33.65  ? 1001 TYR B CE2 1 
ATOM   3120 C CZ  . TYR B 1 151 ? -77.214  67.038 28.621  1.00 34.69  ? 1001 TYR B CZ  1 
ATOM   3121 O OH  . TYR B 1 151 ? -76.772  66.082 29.508  1.00 32.13  ? 1001 TYR B OH  1 
ATOM   3122 N N   . GLY B 1 152 ? -81.421  71.199 24.302  1.00 34.46  ? 1002 GLY B N   1 
ATOM   3123 C CA  . GLY B 1 152 ? -81.878  72.390 23.632  1.00 32.28  ? 1002 GLY B CA  1 
ATOM   3124 C C   . GLY B 1 152 ? -81.322  73.635 24.287  1.00 31.27  ? 1002 GLY B C   1 
ATOM   3125 O O   . GLY B 1 152 ? -80.569  73.580 25.269  1.00 34.02  ? 1002 GLY B O   1 
ATOM   3126 N N   . PRO B 1 153 ? -81.691  74.794 23.732  1.00 35.85  ? 1003 PRO B N   1 
ATOM   3127 C CA  . PRO B 1 153 ? -81.055  76.055 24.161  1.00 33.62  ? 1003 PRO B CA  1 
ATOM   3128 C C   . PRO B 1 153 ? -81.060  76.307 25.663  1.00 32.05  ? 1003 PRO B C   1 
ATOM   3129 O O   . PRO B 1 153 ? -80.058  76.804 26.193  1.00 34.68  ? 1003 PRO B O   1 
ATOM   3130 C CB  . PRO B 1 153 ? -81.868  77.123 23.419  1.00 36.16  ? 1003 PRO B CB  1 
ATOM   3131 C CG  . PRO B 1 153 ? -82.437  76.435 22.231  1.00 39.35  ? 1003 PRO B CG  1 
ATOM   3132 C CD  . PRO B 1 153 ? -82.462  74.951 22.486  1.00 36.89  ? 1003 PRO B CD  1 
ATOM   3133 N N   . HIS B 1 154 ? -82.147  75.983 26.371  1.00 34.33  ? 1004 HIS B N   1 
ATOM   3134 C CA  . HIS B 1 154 ? -82.197  76.293 27.796  1.00 35.20  ? 1004 HIS B CA  1 
ATOM   3135 C C   . HIS B 1 154 ? -81.194  75.484 28.607  1.00 36.05  ? 1004 HIS B C   1 
ATOM   3136 O O   . HIS B 1 154 ? -80.888  75.864 29.742  1.00 37.24  ? 1004 HIS B O   1 
ATOM   3137 C CB  . HIS B 1 154 ? -83.601  76.064 28.361  1.00 35.32  ? 1004 HIS B CB  1 
ATOM   3138 C CG  . HIS B 1 154 ? -84.574  77.151 28.027  1.00 35.95  ? 1004 HIS B CG  1 
ATOM   3139 N ND1 . HIS B 1 154 ? -85.636  76.960 27.170  1.00 42.28  ? 1004 HIS B ND1 1 
ATOM   3140 C CD2 . HIS B 1 154 ? -84.639  78.443 28.425  1.00 39.91  ? 1004 HIS B CD2 1 
ATOM   3141 C CE1 . HIS B 1 154 ? -86.320  78.086 27.063  1.00 37.42  ? 1004 HIS B CE1 1 
ATOM   3142 N NE2 . HIS B 1 154 ? -85.735  79.002 27.813  1.00 44.53  ? 1004 HIS B NE2 1 
ATOM   3143 N N   . PHE B 1 155 ? -80.688  74.377 28.068  1.00 31.69  ? 1005 PHE B N   1 
ATOM   3144 C CA  . PHE B 1 155 ? -79.699  73.575 28.772  1.00 30.92  ? 1005 PHE B CA  1 
ATOM   3145 C C   . PHE B 1 155 ? -78.318  73.642 28.131  1.00 32.00  ? 1005 PHE B C   1 
ATOM   3146 O O   . PHE B 1 155 ? -77.424  72.889 28.531  1.00 33.62  ? 1005 PHE B O   1 
ATOM   3147 C CB  . PHE B 1 155 ? -80.180  72.126 28.881  1.00 28.35  ? 1005 PHE B CB  1 
ATOM   3148 C CG  . PHE B 1 155 ? -81.179  71.911 29.986  1.00 30.05  ? 1005 PHE B CG  1 
ATOM   3149 C CD1 . PHE B 1 155 ? -82.513  72.237 29.800  1.00 29.87  ? 1005 PHE B CD1 1 
ATOM   3150 C CD2 . PHE B 1 155 ? -80.782  71.413 31.217  1.00 30.88  ? 1005 PHE B CD2 1 
ATOM   3151 C CE1 . PHE B 1 155 ? -83.436  72.055 30.814  1.00 31.91  ? 1005 PHE B CE1 1 
ATOM   3152 C CE2 . PHE B 1 155 ? -81.702  71.228 32.237  1.00 28.26  ? 1005 PHE B CE2 1 
ATOM   3153 C CZ  . PHE B 1 155 ? -83.030  71.550 32.034  1.00 31.30  ? 1005 PHE B CZ  1 
ATOM   3154 N N   . GLN B 1 156 ? -78.110  74.539 27.166  1.00 34.04  ? 1006 GLN B N   1 
ATOM   3155 C CA  . GLN B 1 156 ? -76.790  74.722 26.556  1.00 31.74  ? 1006 GLN B CA  1 
ATOM   3156 C C   . GLN B 1 156 ? -76.027  75.831 27.282  1.00 37.06  ? 1006 GLN B C   1 
ATOM   3157 O O   . GLN B 1 156 ? -75.705  76.884 26.729  1.00 42.17  ? 1006 GLN B O   1 
ATOM   3158 C CB  . GLN B 1 156 ? -76.925  75.025 25.071  1.00 36.94  ? 1006 GLN B CB  1 
ATOM   3159 C CG  . GLN B 1 156 ? -77.395  73.855 24.233  1.00 33.45  ? 1006 GLN B CG  1 
ATOM   3160 C CD  . GLN B 1 156 ? -77.464  74.197 22.760  1.00 38.42  ? 1006 GLN B CD  1 
ATOM   3161 O OE1 . GLN B 1 156 ? -76.832  75.149 22.302  1.00 40.55  ? 1006 GLN B OE1 1 
ATOM   3162 N NE2 . GLN B 1 156 ? -78.233  73.419 22.007  1.00 40.35  ? 1006 GLN B NE2 1 
ATOM   3163 N N   . GLY B 1 157 ? -75.679  75.542 28.534  1.00 32.37  ? 1007 GLY B N   1 
ATOM   3164 C CA  . GLY B 1 157 ? -75.004  76.508 29.376  1.00 32.15  ? 1007 GLY B CA  1 
ATOM   3165 C C   . GLY B 1 157 ? -73.495  76.450 29.379  1.00 32.76  ? 1007 GLY B C   1 
ATOM   3166 O O   . GLY B 1 157 ? -72.857  77.333 29.958  1.00 35.52  ? 1007 GLY B O   1 
ATOM   3167 N N   . ILE B 1 158 ? -72.890  75.432 28.775  1.00 32.21  ? 1008 ILE B N   1 
ATOM   3168 C CA  . ILE B 1 158 ? -71.439  75.411 28.625  1.00 34.05  ? 1008 ILE B CA  1 
ATOM   3169 C C   . ILE B 1 158 ? -71.067  76.382 27.506  1.00 36.19  ? 1008 ILE B C   1 
ATOM   3170 O O   . ILE B 1 158 ? -71.433  76.166 26.346  1.00 39.41  ? 1008 ILE B O   1 
ATOM   3171 C CB  . ILE B 1 158 ? -70.926  73.993 28.320  1.00 33.94  ? 1008 ILE B CB  1 
ATOM   3172 C CG1 . ILE B 1 158 ? -71.250  73.017 29.456  1.00 32.11  ? 1008 ILE B CG1 1 
ATOM   3173 C CG2 . ILE B 1 158 ? -69.422  74.013 28.111  1.00 33.12  ? 1008 ILE B CG2 1 
ATOM   3174 C CD1 . ILE B 1 158 ? -70.908  71.567 29.127  1.00 32.40  ? 1008 ILE B CD1 1 
ATOM   3175 N N   . LEU B 1 159 ? -70.372  77.439 27.861  1.00 39.83  ? 1009 LEU B N   1 
ATOM   3176 C CA  . LEU B 1 159 ? -69.959  78.440 26.859  1.00 42.12  ? 1009 LEU B CA  1 
ATOM   3177 C C   . LEU B 1 159 ? -68.689  77.947 26.181  1.00 43.14  ? 1009 LEU B C   1 
ATOM   3178 O O   . LEU B 1 159 ? -68.620  78.016 24.965  1.00 46.23  ? 1009 LEU B O   1 
ATOM   3179 C CB  . LEU B 1 159 ? -69.705  79.747 27.600  1.00 43.84  ? 1009 LEU B CB  1 
ATOM   3180 C CG  . LEU B 1 159 ? -70.834  80.765 27.508  1.00 59.66  ? 1009 LEU B CG  1 
ATOM   3181 C CD1 . LEU B 1 159 ? -70.730  81.540 26.204  1.00 54.23  ? 1009 LEU B CD1 1 
ATOM   3182 C CD2 . LEU B 1 159 ? -72.177  80.062 27.592  1.00 52.56  ? 1009 LEU B CD2 1 
ATOM   3183 N N   . GLU B 1 160 ? -67.738  77.485 26.975  1.00 43.23  ? 1010 GLU B N   1 
ATOM   3184 C CA  . GLU B 1 160 ? -66.450  76.984 26.454  1.00 46.24  ? 1010 GLU B CA  1 
ATOM   3185 C C   . GLU B 1 160 ? -65.980  75.847 27.335  1.00 47.15  ? 1010 GLU B C   1 
ATOM   3186 O O   . GLU B 1 160 ? -66.338  75.825 28.507  1.00 42.26  ? 1010 GLU B O   1 
ATOM   3187 C CB  . GLU B 1 160 ? -65.340  78.023 26.562  1.00 50.35  ? 1010 GLU B CB  1 
ATOM   3188 C CG  . GLU B 1 160 ? -65.815  79.442 26.767  1.00 59.29  ? 1010 GLU B CG  1 
ATOM   3189 C CD  . GLU B 1 160 ? -64.670  80.438 26.760  1.00 67.09  ? 1010 GLU B CD  1 
ATOM   3190 O OE1 . GLU B 1 160 ? -63.758  80.287 27.588  1.00 68.66  ? 1010 GLU B OE1 1 
ATOM   3191 O OE2 . GLU B 1 160 ? -64.692  81.351 25.923  1.00 71.21  ? 1010 GLU B OE2 1 
ATOM   3192 N N   . ALA B 1 161 ? -65.196  74.955 26.765  1.00 40.09  ? 1011 ALA B N   1 
ATOM   3193 C CA  . ALA B 1 161 ? -64.599  73.896 27.585  1.00 42.86  ? 1011 ALA B CA  1 
ATOM   3194 C C   . ALA B 1 161 ? -63.183  73.575 27.114  1.00 50.95  ? 1011 ALA B C   1 
ATOM   3195 O O   . ALA B 1 161 ? -62.873  73.824 25.956  1.00 48.39  ? 1011 ALA B O   1 
ATOM   3196 C CB  . ALA B 1 161 ? -65.445  72.667 27.526  1.00 41.04  ? 1011 ALA B CB  1 
ATOM   3197 N N   . SER B 1 162 ? -62.383  73.027 28.008  1.00 49.40  ? 1012 SER B N   1 
ATOM   3198 C CA  . SER B 1 162 ? -61.038  72.540 27.645  1.00 46.40  ? 1012 SER B CA  1 
ATOM   3199 C C   . SER B 1 162 ? -61.182  71.392 26.658  1.00 52.49  ? 1012 SER B C   1 
ATOM   3200 O O   . SER B 1 162 ? -62.238  70.762 26.605  1.00 49.97  ? 1012 SER B O   1 
ATOM   3201 C CB  . SER B 1 162 ? -60.314  72.071 28.870  1.00 50.92  ? 1012 SER B CB  1 
ATOM   3202 O OG  . SER B 1 162 ? -60.914  70.914 29.415  1.00 56.73  ? 1012 SER B OG  1 
ATOM   3203 N N   . LEU B 1 163 ? -60.114  71.124 25.922  1.00 55.05  ? 1013 LEU B N   1 
ATOM   3204 C CA  . LEU B 1 163 ? -60.142  70.015 24.945  1.00 53.71  ? 1013 LEU B CA  1 
ATOM   3205 C C   . LEU B 1 163 ? -60.351  68.704 25.696  1.00 46.72  ? 1013 LEU B C   1 
ATOM   3206 O O   . LEU B 1 163 ? -60.983  67.826 25.135  1.00 51.08  ? 1013 LEU B O   1 
ATOM   3207 C CB  . LEU B 1 163 ? -58.807  70.031 24.200  1.00 56.22  ? 1013 LEU B CB  1 
ATOM   3208 C CG  . LEU B 1 163 ? -58.782  70.815 22.889  1.00 60.69  ? 1013 LEU B CG  1 
ATOM   3209 C CD1 . LEU B 1 163 ? -59.329  72.220 23.073  1.00 60.08  ? 1013 LEU B CD1 1 
ATOM   3210 C CD2 . LEU B 1 163 ? -57.372  70.872 22.323  1.00 59.52  ? 1013 LEU B CD2 1 
ATOM   3211 N N   . GLU B 1 164 ? -59.828  68.611 26.914  1.00 48.54  ? 1014 GLU B N   1 
ATOM   3212 C CA  . GLU B 1 164 ? -59.978  67.387 27.742  1.00 54.14  ? 1014 GLU B CA  1 
ATOM   3213 C C   . GLU B 1 164 ? -61.263  67.436 28.569  1.00 54.73  ? 1014 GLU B C   1 
ATOM   3214 O O   . GLU B 1 164 ? -61.543  66.460 29.257  1.00 53.67  ? 1014 GLU B O   1 
ATOM   3215 C CB  . GLU B 1 164 ? -58.800  67.229 28.685  1.00 60.61  ? 1014 GLU B CB  1 
ATOM   3216 C CG  . GLU B 1 164 ? -58.029  65.944 28.441  1.00 72.26  ? 1014 GLU B CG  1 
ATOM   3217 C CD  . GLU B 1 164 ? -58.898  64.707 28.289  1.00 77.54  ? 1014 GLU B CD  1 
ATOM   3218 O OE1 . GLU B 1 164 ? -59.644  64.395 29.234  1.00 79.62  ? 1014 GLU B OE1 1 
ATOM   3219 O OE2 . GLU B 1 164 ? -58.827  64.055 27.226  1.00 83.52  ? 1014 GLU B OE2 1 
ATOM   3220 N N   . GLY B 1 165 ? -61.985  68.545 28.524  1.00 50.48  ? 1015 GLY B N   1 
ATOM   3221 C CA  . GLY B 1 165 ? -63.285  68.633 29.213  1.00 51.32  ? 1015 GLY B CA  1 
ATOM   3222 C C   . GLY B 1 165 ? -63.187  68.673 30.720  1.00 52.11  ? 1015 GLY B C   1 
ATOM   3223 O O   . GLY B 1 165 ? -64.115  68.189 31.358  1.00 53.24  ? 1015 GLY B O   1 
ATOM   3224 N N   . ASP B 1 166 ? -62.121  69.245 31.257  1.00 47.64  ? 1016 ASP B N   1 
ATOM   3225 C CA  . ASP B 1 166 ? -61.894  69.238 32.719  1.00 47.46  ? 1016 ASP B CA  1 
ATOM   3226 C C   . ASP B 1 166 ? -62.018  70.654 33.271  1.00 39.78  ? 1016 ASP B C   1 
ATOM   3227 O O   . ASP B 1 166 ? -61.837  70.833 34.462  1.00 44.17  ? 1016 ASP B O   1 
ATOM   3228 C CB  . ASP B 1 166 ? -60.528  68.637 33.024  1.00 52.90  ? 1016 ASP B CB  1 
ATOM   3229 C CG  . ASP B 1 166 ? -59.385  69.365 32.348  1.00 58.10  ? 1016 ASP B CG  1 
ATOM   3230 O OD1 . ASP B 1 166 ? -59.462  69.549 31.125  1.00 64.13  ? 1016 ASP B OD1 1 
ATOM   3231 O OD2 . ASP B 1 166 ? -58.421  69.719 33.047  1.00 61.67  ? 1016 ASP B OD2 1 
ATOM   3232 N N   . SER B 1 167 ? -62.280  71.610 32.393  1.00 43.98  ? 1017 SER B N   1 
ATOM   3233 C CA  . SER B 1 167 ? -62.416  73.020 32.813  1.00 39.74  ? 1017 SER B CA  1 
ATOM   3234 C C   . SER B 1 167 ? -63.313  73.755 31.825  1.00 41.92  ? 1017 SER B C   1 
ATOM   3235 O O   . SER B 1 167 ? -63.481  73.273 30.709  1.00 43.64  ? 1017 SER B O   1 
ATOM   3236 C CB  . SER B 1 167 ? -61.084  73.691 32.926  1.00 48.67  ? 1017 SER B CB  1 
ATOM   3237 O OG  . SER B 1 167 ? -60.505  73.890 31.653  1.00 50.89  ? 1017 SER B OG  1 
ATOM   3238 N N   . GLY B 1 168 ? -63.878  74.868 32.266  1.00 38.11  ? 1018 GLY B N   1 
ATOM   3239 C CA  . GLY B 1 168 ? -64.687  75.674 31.354  1.00 39.76  ? 1018 GLY B CA  1 
ATOM   3240 C C   . GLY B 1 168 ? -65.442  76.828 31.977  1.00 33.51  ? 1018 GLY B C   1 
ATOM   3241 O O   . GLY B 1 168 ? -65.133  77.211 33.092  1.00 36.83  ? 1018 GLY B O   1 
ATOM   3242 N N   . ARG B 1 169 ? -66.375  77.366 31.218  1.00 34.12  ? 1019 ARG B N   1 
ATOM   3243 C CA  . ARG B 1 169 ? -67.190  78.505 31.680  1.00 39.86  ? 1019 ARG B CA  1 
ATOM   3244 C C   . ARG B 1 169 ? -68.652  78.129 31.504  1.00 34.40  ? 1019 ARG B C   1 
ATOM   3245 O O   . ARG B 1 169 ? -69.015  77.662 30.436  1.00 34.77  ? 1019 ARG B O   1 
ATOM   3246 C CB  . ARG B 1 169 ? -66.919  79.785 30.890  1.00 43.28  ? 1019 ARG B CB  1 
ATOM   3247 C CG  . ARG B 1 169 ? -65.735  80.613 31.357  1.00 52.81  ? 1019 ARG B CG  1 
ATOM   3248 C CD  . ARG B 1 169 ? -65.751  81.858 30.495  1.00 57.44  ? 1019 ARG B CD  1 
ATOM   3249 N NE  . ARG B 1 169 ? -64.564  82.674 30.645  1.00 62.35  ? 1019 ARG B NE  1 
ATOM   3250 C CZ  . ARG B 1 169 ? -64.296  83.739 29.906  1.00 63.37  ? 1019 ARG B CZ  1 
ATOM   3251 N NH1 . ARG B 1 169 ? -64.988  83.968 28.805  1.00 63.34  ? 1019 ARG B NH1 1 
ATOM   3252 N NH2 . ARG B 1 169 ? -63.326  84.560 30.263  1.00 70.64  ? 1019 ARG B NH2 1 
ATOM   3253 N N   . LEU B 1 170 ? -69.426  78.360 32.548  1.00 35.17  ? 1020 LEU B N   1 
ATOM   3254 C CA  . LEU B 1 170 ? -70.859  78.022 32.509  1.00 32.65  ? 1020 LEU B CA  1 
ATOM   3255 C C   . LEU B 1 170 ? -71.679  79.297 32.638  1.00 31.62  ? 1020 LEU B C   1 
ATOM   3256 O O   . LEU B 1 170 ? -71.356  80.126 33.467  1.00 36.24  ? 1020 LEU B O   1 
ATOM   3257 C CB  . LEU B 1 170 ? -71.180  77.058 33.652  1.00 35.17  ? 1020 LEU B CB  1 
ATOM   3258 C CG  . LEU B 1 170 ? -70.395  75.749 33.705  1.00 29.52  ? 1020 LEU B CG  1 
ATOM   3259 C CD1 . LEU B 1 170 ? -70.833  74.921 34.903  1.00 32.11  ? 1020 LEU B CD1 1 
ATOM   3260 C CD2 . LEU B 1 170 ? -70.578  74.956 32.427  1.00 32.12  ? 1020 LEU B CD2 1 
ATOM   3261 N N   . LEU B 1 171 ? -72.703  79.391 31.824  1.00 32.45  ? 1021 LEU B N   1 
ATOM   3262 C CA  . LEU B 1 171 ? -73.625  80.535 31.885  1.00 33.29  ? 1021 LEU B CA  1 
ATOM   3263 C C   . LEU B 1 171 ? -74.526  80.438 33.110  1.00 33.61  ? 1021 LEU B C   1 
ATOM   3264 O O   . LEU B 1 171 ? -74.862  79.332 33.491  1.00 34.64  ? 1021 LEU B O   1 
ATOM   3265 C CB  . LEU B 1 171 ? -74.481  80.473 30.627  1.00 38.47  ? 1021 LEU B CB  1 
ATOM   3266 C CG  . LEU B 1 171 ? -74.583  81.771 29.832  1.00 56.13  ? 1021 LEU B CG  1 
ATOM   3267 C CD1 . LEU B 1 171 ? -75.422  82.790 30.575  1.00 55.20  ? 1021 LEU B CD1 1 
ATOM   3268 C CD2 . LEU B 1 171 ? -73.205  82.342 29.557  1.00 56.67  ? 1021 LEU B CD2 1 
ATOM   3269 N N   . TRP B 1 172 ? -74.870  81.577 33.689  1.00 34.26  ? 1022 TRP B N   1 
ATOM   3270 C CA  . TRP B 1 172 ? -75.849  81.638 34.796  1.00 33.08  ? 1022 TRP B CA  1 
ATOM   3271 C C   . TRP B 1 172 ? -77.061  82.401 34.271  1.00 42.21  ? 1022 TRP B C   1 
ATOM   3272 O O   . TRP B 1 172 ? -76.883  83.544 33.869  1.00 42.01  ? 1022 TRP B O   1 
ATOM   3273 C CB  . TRP B 1 172 ? -75.277  82.321 36.026  1.00 33.96  ? 1022 TRP B CB  1 
ATOM   3274 C CG  . TRP B 1 172 ? -76.285  82.555 37.102  1.00 37.61  ? 1022 TRP B CG  1 
ATOM   3275 C CD1 . TRP B 1 172 ? -76.763  83.756 37.532  1.00 39.09  ? 1022 TRP B CD1 1 
ATOM   3276 C CD2 . TRP B 1 172 ? -76.927  81.554 37.905  1.00 34.62  ? 1022 TRP B CD2 1 
ATOM   3277 N NE1 . TRP B 1 172 ? -77.671  83.570 38.536  1.00 39.28  ? 1022 TRP B NE1 1 
ATOM   3278 C CE2 . TRP B 1 172 ? -77.789  82.231 38.791  1.00 37.94  ? 1022 TRP B CE2 1 
ATOM   3279 C CE3 . TRP B 1 172 ? -76.863  80.159 37.957  1.00 34.41  ? 1022 TRP B CE3 1 
ATOM   3280 C CZ2 . TRP B 1 172 ? -78.578  81.556 39.718  1.00 36.34  ? 1022 TRP B CZ2 1 
ATOM   3281 C CZ3 . TRP B 1 172 ? -77.640  79.495 38.877  1.00 33.94  ? 1022 TRP B CZ3 1 
ATOM   3282 C CH2 . TRP B 1 172 ? -78.485  80.186 39.742  1.00 31.30  ? 1022 TRP B CH2 1 
ATOM   3283 N N   . LYS B 1 173 ? -78.216  81.770 34.247  1.00 35.80  ? 1023 LYS B N   1 
ATOM   3284 C CA  . LYS B 1 173 ? -79.455  82.382 33.725  1.00 36.80  ? 1023 LYS B CA  1 
ATOM   3285 C C   . LYS B 1 173 ? -80.489  82.349 34.846  1.00 34.31  ? 1023 LYS B C   1 
ATOM   3286 O O   . LYS B 1 173 ? -81.654  82.129 34.557  1.00 38.56  ? 1023 LYS B O   1 
ATOM   3287 C CB  . LYS B 1 173 ? -79.885  81.601 32.489  1.00 41.80  ? 1023 LYS B CB  1 
ATOM   3288 C CG  . LYS B 1 173 ? -78.813  81.397 31.430  1.00 47.44  ? 1023 LYS B CG  1 
ATOM   3289 C CD  . LYS B 1 173 ? -79.266  80.484 30.312  1.00 53.91  ? 1023 LYS B CD  1 
ATOM   3290 C CE  . LYS B 1 173 ? -78.213  80.247 29.249  1.00 60.68  ? 1023 LYS B CE  1 
ATOM   3291 N NZ  . LYS B 1 173 ? -78.661  79.264 28.233  1.00 49.85  ? 1023 LYS B NZ  1 
ATOM   3292 N N   . ASP B 1 174 ? -80.034  82.549 36.074  1.00 35.53  ? 1024 ASP B N   1 
ATOM   3293 C CA  . ASP B 1 174 ? -80.906  82.514 37.249  1.00 38.76  ? 1024 ASP B CA  1 
ATOM   3294 C C   . ASP B 1 174 ? -81.757  81.249 37.262  1.00 39.53  ? 1024 ASP B C   1 
ATOM   3295 O O   . ASP B 1 174 ? -82.972  81.284 37.468  1.00 37.07  ? 1024 ASP B O   1 
ATOM   3296 C CB  . ASP B 1 174 ? -81.771  83.771 37.340  1.00 40.36  ? 1024 ASP B CB  1 
ATOM   3297 C CG  . ASP B 1 174 ? -82.304  84.003 38.740  1.00 51.59  ? 1024 ASP B CG  1 
ATOM   3298 O OD1 . ASP B 1 174 ? -81.489  84.020 39.688  1.00 59.61  ? 1024 ASP B OD1 1 
ATOM   3299 O OD2 . ASP B 1 174 ? -83.531  84.168 38.894  1.00 66.83  ? 1024 ASP B OD2 1 
ATOM   3300 N N   . ASN B 1 175 ? -81.115  80.128 36.946  1.00 33.52  ? 1025 ASN B N   1 
ATOM   3301 C CA  . ASN B 1 175 ? -81.773  78.828 36.901  1.00 30.77  ? 1025 ASN B CA  1 
ATOM   3302 C C   . ASN B 1 175 ? -80.839  77.807 37.542  1.00 31.73  ? 1025 ASN B C   1 
ATOM   3303 O O   . ASN B 1 175 ? -79.840  77.417 36.930  1.00 30.88  ? 1025 ASN B O   1 
ATOM   3304 C CB  . ASN B 1 175 ? -82.109  78.467 35.454  1.00 29.04  ? 1025 ASN B CB  1 
ATOM   3305 C CG  . ASN B 1 175 ? -82.952  77.218 35.332  1.00 34.07  ? 1025 ASN B CG  1 
ATOM   3306 O OD1 . ASN B 1 175 ? -82.740  76.231 36.034  1.00 30.90  ? 1025 ASN B OD1 1 
ATOM   3307 N ND2 . ASN B 1 175 ? -83.913  77.251 34.416  1.00 32.82  ? 1025 ASN B ND2 1 
ATOM   3308 N N   . TRP B 1 176 ? -81.157  77.370 38.765  1.00 26.99  ? 1026 TRP B N   1 
ATOM   3309 C CA  . TRP B 1 176 ? -80.297  76.404 39.447  1.00 27.88  ? 1026 TRP B CA  1 
ATOM   3310 C C   . TRP B 1 176 ? -80.320  75.043 38.767  1.00 30.92  ? 1026 TRP B C   1 
ATOM   3311 O O   . TRP B 1 176 ? -79.293  74.348 38.728  1.00 30.74  ? 1026 TRP B O   1 
ATOM   3312 C CB  . TRP B 1 176 ? -80.729  76.250 40.905  1.00 28.59  ? 1026 TRP B CB  1 
ATOM   3313 C CG  . TRP B 1 176 ? -80.332  77.383 41.779  1.00 28.09  ? 1026 TRP B CG  1 
ATOM   3314 C CD1 . TRP B 1 176 ? -81.143  78.362 42.268  1.00 32.10  ? 1026 TRP B CD1 1 
ATOM   3315 C CD2 . TRP B 1 176 ? -79.025  77.645 42.297  1.00 27.75  ? 1026 TRP B CD2 1 
ATOM   3316 N NE1 . TRP B 1 176 ? -80.419  79.229 43.049  1.00 32.20  ? 1026 TRP B NE1 1 
ATOM   3317 C CE2 . TRP B 1 176 ? -79.115  78.809 43.085  1.00 30.40  ? 1026 TRP B CE2 1 
ATOM   3318 C CE3 . TRP B 1 176 ? -77.785  77.011 42.168  1.00 30.66  ? 1026 TRP B CE3 1 
ATOM   3319 C CZ2 . TRP B 1 176 ? -78.014  79.353 43.739  1.00 29.89  ? 1026 TRP B CZ2 1 
ATOM   3320 C CZ3 . TRP B 1 176 ? -76.694  77.553 42.818  1.00 30.54  ? 1026 TRP B CZ3 1 
ATOM   3321 C CH2 . TRP B 1 176 ? -76.815  78.712 43.594  1.00 30.14  ? 1026 TRP B CH2 1 
ATOM   3322 N N   . VAL B 1 177 ? -81.465  74.662 38.198  1.00 27.68  ? 1027 VAL B N   1 
ATOM   3323 C CA  . VAL B 1 177 ? -81.597  73.330 37.619  1.00 26.92  ? 1027 VAL B CA  1 
ATOM   3324 C C   . VAL B 1 177 ? -80.691  73.195 36.402  1.00 27.65  ? 1027 VAL B C   1 
ATOM   3325 O O   . VAL B 1 177 ? -79.901  72.247 36.294  1.00 28.51  ? 1027 VAL B O   1 
ATOM   3326 C CB  . VAL B 1 177 ? -83.068  73.042 37.264  1.00 27.05  ? 1027 VAL B CB  1 
ATOM   3327 C CG1 . VAL B 1 177 ? -83.174  71.799 36.392  1.00 27.59  ? 1027 VAL B CG1 1 
ATOM   3328 C CG2 . VAL B 1 177 ? -83.901  72.892 38.521  1.00 27.02  ? 1027 VAL B CG2 1 
ATOM   3329 N N   . SER B 1 178 ? -80.753  74.167 35.489  1.00 27.23  ? 1028 SER B N   1 
ATOM   3330 C CA  . SER B 1 178 ? -79.929  74.075 34.290  1.00 25.61  ? 1028 SER B CA  1 
ATOM   3331 C C   . SER B 1 178 ? -78.454  74.331 34.591  1.00 26.78  ? 1028 SER B C   1 
ATOM   3332 O O   . SER B 1 178 ? -77.586  73.695 33.982  1.00 28.93  ? 1028 SER B O   1 
ATOM   3333 C CB  . SER B 1 178 ? -80.443  75.036 33.216  1.00 26.83  ? 1028 SER B CB  1 
ATOM   3334 O OG  . SER B 1 178 ? -80.389  76.381 33.651  1.00 28.17  ? 1028 SER B OG  1 
ATOM   3335 N N   . PHE B 1 179 ? -78.142  75.227 35.533  1.00 27.66  ? 1029 PHE B N   1 
ATOM   3336 C CA  . PHE B 1 179 ? -76.741  75.432 35.901  1.00 25.40  ? 1029 PHE B CA  1 
ATOM   3337 C C   . PHE B 1 179 ? -76.111  74.139 36.417  1.00 28.01  ? 1029 PHE B C   1 
ATOM   3338 O O   . PHE B 1 179 ? -75.049  73.696 35.935  1.00 28.99  ? 1029 PHE B O   1 
ATOM   3339 C CB  . PHE B 1 179 ? -76.619  76.538 36.953  1.00 27.12  ? 1029 PHE B CB  1 
ATOM   3340 C CG  . PHE B 1 179 ? -75.197  76.847 37.331  1.00 29.02  ? 1029 PHE B CG  1 
ATOM   3341 C CD1 . PHE B 1 179 ? -74.433  77.711 36.563  1.00 27.77  ? 1029 PHE B CD1 1 
ATOM   3342 C CD2 . PHE B 1 179 ? -74.613  76.246 38.436  1.00 29.61  ? 1029 PHE B CD2 1 
ATOM   3343 C CE1 . PHE B 1 179 ? -73.118  77.981 36.900  1.00 31.38  ? 1029 PHE B CE1 1 
ATOM   3344 C CE2 . PHE B 1 179 ? -73.299  76.510 38.777  1.00 26.27  ? 1029 PHE B CE2 1 
ATOM   3345 C CZ  . PHE B 1 179 ? -72.551  77.380 38.008  1.00 32.45  ? 1029 PHE B CZ  1 
ATOM   3346 N N   . MET B 1 180 ? -76.755  73.506 37.399  1.00 27.58  ? 1030 MET B N   1 
ATOM   3347 C CA  . MET B 1 180 ? -76.173  72.282 37.932  1.00 26.82  ? 1030 MET B CA  1 
ATOM   3348 C C   . MET B 1 180 ? -76.167  71.167 36.890  1.00 27.97  ? 1030 MET B C   1 
ATOM   3349 O O   . MET B 1 180 ? -75.234  70.339 36.860  1.00 27.21  ? 1030 MET B O   1 
ATOM   3350 C CB  . MET B 1 180 ? -76.913  71.869 39.202  1.00 24.76  ? 1030 MET B CB  1 
ATOM   3351 C CG  . MET B 1 180 ? -76.667  72.831 40.356  1.00 25.80  ? 1030 MET B CG  1 
ATOM   3352 S SD  . MET B 1 180 ? -77.299  72.230 41.930  1.00 29.63  ? 1030 MET B SD  1 
ATOM   3353 C CE  . MET B 1 180 ? -79.060  72.444 41.686  1.00 29.04  ? 1030 MET B CE  1 
ATOM   3354 N N   . ASP B 1 181 ? -77.160  71.150 35.992  1.00 25.79  ? 1031 ASP B N   1 
ATOM   3355 C CA  . ASP B 1 181 ? -77.120  70.153 34.931  1.00 26.90  ? 1031 ASP B CA  1 
ATOM   3356 C C   . ASP B 1 181 ? -75.904  70.353 34.040  1.00 27.23  ? 1031 ASP B C   1 
ATOM   3357 O O   . ASP B 1 181 ? -75.286  69.378 33.610  1.00 29.40  ? 1031 ASP B O   1 
ATOM   3358 C CB  . ASP B 1 181 ? -78.393  70.186 34.091  1.00 27.40  ? 1031 ASP B CB  1 
ATOM   3359 C CG  . ASP B 1 181 ? -78.472  69.013 33.125  1.00 32.83  ? 1031 ASP B CG  1 
ATOM   3360 O OD1 . ASP B 1 181 ? -78.679  67.871 33.589  1.00 34.75  ? 1031 ASP B OD1 1 
ATOM   3361 O OD2 . ASP B 1 181 ? -78.306  69.224 31.905  1.00 31.42  ? 1031 ASP B OD2 1 
ATOM   3362 N N   . THR B 1 182 ? -75.532  71.605 33.759  1.00 28.27  ? 1032 THR B N   1 
ATOM   3363 C CA  . THR B 1 182 ? -74.344  71.800 32.931  1.00 30.45  ? 1032 THR B CA  1 
ATOM   3364 C C   . THR B 1 182 ? -73.062  71.409 33.662  1.00 30.46  ? 1032 THR B C   1 
ATOM   3365 O O   . THR B 1 182 ? -72.076  71.044 33.004  1.00 29.72  ? 1032 THR B O   1 
ATOM   3366 C CB  . THR B 1 182 ? -74.256  73.241 32.414  1.00 28.53  ? 1032 THR B CB  1 
ATOM   3367 O OG1 . THR B 1 182 ? -74.148  74.159 33.508  1.00 30.86  ? 1032 THR B OG1 1 
ATOM   3368 C CG2 . THR B 1 182 ? -75.473  73.579 31.556  1.00 31.24  ? 1032 THR B CG2 1 
ATOM   3369 N N   . MET B 1 183 ? -73.055  71.428 35.001  1.00 30.60  ? 1033 MET B N   1 
ATOM   3370 C CA  . MET B 1 183 ? -71.914  70.805 35.688  1.00 27.21  ? 1033 MET B CA  1 
ATOM   3371 C C   . MET B 1 183 ? -71.863  69.292 35.443  1.00 31.95  ? 1033 MET B C   1 
ATOM   3372 O O   . MET B 1 183 ? -70.784  68.724 35.188  1.00 32.30  ? 1033 MET B O   1 
ATOM   3373 C CB  . MET B 1 183 ? -71.939  71.091 37.191  1.00 30.13  ? 1033 MET B CB  1 
ATOM   3374 C CG  . MET B 1 183 ? -72.149  72.543 37.554  1.00 30.45  ? 1033 MET B CG  1 
ATOM   3375 S SD  . MET B 1 183 ? -72.292  72.833 39.330  1.00 29.73  ? 1033 MET B SD  1 
ATOM   3376 C CE  . MET B 1 183 ? -70.893  71.911 39.971  1.00 29.32  ? 1033 MET B CE  1 
ATOM   3377 N N   . LEU B 1 184 ? -73.022  68.626 35.497  1.00 28.42  ? 1034 LEU B N   1 
ATOM   3378 C CA  . LEU B 1 184 ? -73.040  67.198 35.162  1.00 28.31  ? 1034 LEU B CA  1 
ATOM   3379 C C   . LEU B 1 184 ? -72.630  66.968 33.709  1.00 36.11  ? 1034 LEU B C   1 
ATOM   3380 O O   . LEU B 1 184 ? -71.961  65.975 33.383  1.00 31.73  ? 1034 LEU B O   1 
ATOM   3381 C CB  . LEU B 1 184 ? -74.428  66.603 35.410  1.00 29.61  ? 1034 LEU B CB  1 
ATOM   3382 C CG  . LEU B 1 184 ? -75.023  66.641 36.818  1.00 35.11  ? 1034 LEU B CG  1 
ATOM   3383 C CD1 . LEU B 1 184 ? -76.251  65.745 36.902  1.00 35.41  ? 1034 LEU B CD1 1 
ATOM   3384 C CD2 . LEU B 1 184 ? -73.989  66.220 37.844  1.00 39.74  ? 1034 LEU B CD2 1 
ATOM   3385 N N   . GLN B 1 185 ? -73.016  67.888 32.824  1.00 29.04  ? 1035 GLN B N   1 
ATOM   3386 C CA  . GLN B 1 185 ? -72.627  67.789 31.422  1.00 30.68  ? 1035 GLN B CA  1 
ATOM   3387 C C   . GLN B 1 185 ? -71.116  67.847 31.271  1.00 31.32  ? 1035 GLN B C   1 
ATOM   3388 O O   . GLN B 1 185 ? -70.540  67.106 30.470  1.00 37.95  ? 1035 GLN B O   1 
ATOM   3389 C CB  . GLN B 1 185 ? -73.261  68.912 30.603  1.00 28.01  ? 1035 GLN B CB  1 
ATOM   3390 C CG  . GLN B 1 185 ? -74.765  68.857 30.431  1.00 30.91  ? 1035 GLN B CG  1 
ATOM   3391 C CD  . GLN B 1 185 ? -75.284  70.131 29.793  1.00 32.98  ? 1035 GLN B CD  1 
ATOM   3392 O OE1 . GLN B 1 185 ? -74.532  70.851 29.135  1.00 32.15  ? 1035 GLN B OE1 1 
ATOM   3393 N NE2 . GLN B 1 185 ? -76.561  70.427 29.998  1.00 30.50  ? 1035 GLN B NE2 1 
ATOM   3394 N N   . MET B 1 186 ? -70.462  68.752 32.006  1.00 30.91  ? 1036 MET B N   1 
ATOM   3395 C CA  . MET B 1 186 ? -69.004  68.826 31.943  1.00 34.83  ? 1036 MET B CA  1 
ATOM   3396 C C   . MET B 1 186 ? -68.359  67.542 32.436  1.00 40.73  ? 1036 MET B C   1 
ATOM   3397 O O   . MET B 1 186 ? -67.364  67.077 31.864  1.00 36.38  ? 1036 MET B O   1 
ATOM   3398 C CB  . MET B 1 186 ? -68.488  70.010 32.752  1.00 31.94  ? 1036 MET B CB  1 
ATOM   3399 C CG  . MET B 1 186 ? -68.761  71.333 32.099  1.00 41.50  ? 1036 MET B CG  1 
ATOM   3400 S SD  . MET B 1 186 ? -67.512  71.709 30.854  1.00 43.50  ? 1036 MET B SD  1 
ATOM   3401 C CE  . MET B 1 186 ? -66.068  70.879 31.519  1.00 38.82  ? 1036 MET B CE  1 
ATOM   3402 N N   . SER B 1 187 ? -68.887  66.981 33.528  1.00 34.18  ? 1037 SER B N   1 
ATOM   3403 C CA  . SER B 1 187 ? -68.406  65.680 33.988  1.00 38.65  ? 1037 SER B CA  1 
ATOM   3404 C C   . SER B 1 187 ? -68.504  64.635 32.880  1.00 38.14  ? 1037 SER B C   1 
ATOM   3405 O O   . SER B 1 187 ? -67.576  63.841 32.676  1.00 47.67  ? 1037 SER B O   1 
ATOM   3406 C CB  . SER B 1 187 ? -69.205  65.235 35.212  1.00 40.03  ? 1037 SER B CB  1 
ATOM   3407 O OG  . SER B 1 187 ? -68.528  64.222 35.932  1.00 47.79  ? 1037 SER B OG  1 
ATOM   3408 N N   . ILE B 1 188 ? -69.623  64.634 32.151  1.00 37.77  ? 1038 ILE B N   1 
ATOM   3409 C CA  . ILE B 1 188 ? -69.835  63.660 31.082  1.00 40.95  ? 1038 ILE B CA  1 
ATOM   3410 C C   . ILE B 1 188 ? -68.861  63.907 29.933  1.00 39.89  ? 1038 ILE B C   1 
ATOM   3411 O O   . ILE B 1 188 ? -68.283  62.965 29.375  1.00 42.50  ? 1038 ILE B O   1 
ATOM   3412 C CB  . ILE B 1 188 ? -71.298  63.739 30.607  1.00 41.03  ? 1038 ILE B CB  1 
ATOM   3413 C CG1 . ILE B 1 188 ? -72.198  62.835 31.445  1.00 45.61  ? 1038 ILE B CG1 1 
ATOM   3414 C CG2 . ILE B 1 188 ? -71.416  63.341 29.148  1.00 41.01  ? 1038 ILE B CG2 1 
ATOM   3415 C CD1 . ILE B 1 188 ? -73.647  63.281 31.432  1.00 49.68  ? 1038 ILE B CD1 1 
ATOM   3416 N N   . LEU B 1 189 ? -68.634  65.182 29.597  1.00 39.32  ? 1039 LEU B N   1 
ATOM   3417 C CA  . LEU B 1 189 ? -67.828  65.555 28.436  1.00 44.48  ? 1039 LEU B CA  1 
ATOM   3418 C C   . LEU B 1 189 ? -66.449  64.925 28.487  1.00 43.07  ? 1039 LEU B C   1 
ATOM   3419 O O   . LEU B 1 189 ? -65.996  64.305 27.518  1.00 44.02  ? 1039 LEU B O   1 
ATOM   3420 C CB  . LEU B 1 189 ? -67.675  67.076 28.359  1.00 41.99  ? 1039 LEU B CB  1 
ATOM   3421 C CG  . LEU B 1 189 ? -67.186  67.689 27.036  1.00 42.01  ? 1039 LEU B CG  1 
ATOM   3422 C CD1 . LEU B 1 189 ? -67.939  67.175 25.815  1.00 42.39  ? 1039 LEU B CD1 1 
ATOM   3423 C CD2 . LEU B 1 189 ? -67.156  69.216 27.081  1.00 40.55  ? 1039 LEU B CD2 1 
ATOM   3424 N N   . GLY B 1 190 ? -65.749  65.111 29.595  1.00 45.51  ? 1040 GLY B N   1 
ATOM   3425 C CA  . GLY B 1 190 ? -64.391  64.633 29.634  1.00 50.07  ? 1040 GLY B CA  1 
ATOM   3426 C C   . GLY B 1 190 ? -64.175  63.196 30.032  1.00 49.36  ? 1040 GLY B C   1 
ATOM   3427 O O   . GLY B 1 190 ? -63.023  62.792 30.216  1.00 54.47  ? 1040 GLY B O   1 
ATOM   3428 N N   . SER B 1 191 ? -65.223  62.387 30.091  1.00 46.67  ? 1041 SER B N   1 
ATOM   3429 C CA  . SER B 1 191 ? -65.065  60.990 30.460  1.00 48.28  ? 1041 SER B CA  1 
ATOM   3430 C C   . SER B 1 191 ? -64.496  60.211 29.282  1.00 48.15  ? 1041 SER B C   1 
ATOM   3431 O O   . SER B 1 191 ? -64.675  60.589 28.121  1.00 45.01  ? 1041 SER B O   1 
ATOM   3432 C CB  . SER B 1 191 ? -66.391  60.374 30.896  1.00 51.15  ? 1041 SER B CB  1 
ATOM   3433 O OG  . SER B 1 191 ? -66.429  59.000 30.549  1.00 57.44  ? 1041 SER B OG  1 
ATOM   3434 N N   . ALA B 1 192 ? -63.740  59.155 29.591  1.00 48.65  ? 1042 ALA B N   1 
ATOM   3435 C CA  . ALA B 1 192 ? -63.234  58.306 28.521  1.00 49.49  ? 1042 ALA B CA  1 
ATOM   3436 C C   . ALA B 1 192 ? -64.311  57.393 27.959  1.00 49.09  ? 1042 ALA B C   1 
ATOM   3437 O O   . ALA B 1 192 ? -64.209  56.969 26.801  1.00 45.77  ? 1042 ALA B O   1 
ATOM   3438 C CB  . ALA B 1 192 ? -62.072  57.457 29.036  1.00 50.17  ? 1042 ALA B CB  1 
ATOM   3439 N N   . LYS B 1 193 ? -65.332  57.136 28.757  1.00 49.71  ? 1043 LYS B N   1 
ATOM   3440 C CA  . LYS B 1 193 ? -66.474  56.319 28.296  1.00 47.81  ? 1043 LYS B CA  1 
ATOM   3441 C C   . LYS B 1 193 ? -67.440  57.247 27.564  1.00 46.53  ? 1043 LYS B C   1 
ATOM   3442 O O   . LYS B 1 193 ? -67.869  58.210 28.169  1.00 45.40  ? 1043 LYS B O   1 
ATOM   3443 C CB  . LYS B 1 193 ? -67.072  55.590 29.495  1.00 45.33  ? 1043 LYS B CB  1 
ATOM   3444 C CG  . LYS B 1 193 ? -66.190  54.532 30.139  1.00 46.65  ? 1043 LYS B CG  1 
ATOM   3445 C CD  . LYS B 1 193 ? -66.889  53.809 31.260  1.00 48.11  ? 1043 LYS B CD  1 
ATOM   3446 C CE  . LYS B 1 193 ? -66.081  52.670 31.842  1.00 54.70  ? 1043 LYS B CE  1 
ATOM   3447 N NZ  . LYS B 1 193 ? -66.906  51.825 32.736  1.00 62.65  ? 1043 LYS B NZ  1 
ATOM   3448 N N   . HIS B 1 194 ? -67.739  56.951 26.306  1.00 44.94  ? 1044 HIS B N   1 
ATOM   3449 C CA  . HIS B 1 194 ? -68.559  57.843 25.494  1.00 40.43  ? 1044 HIS B CA  1 
ATOM   3450 C C   . HIS B 1 194 ? -69.979  57.334 25.265  1.00 37.43  ? 1044 HIS B C   1 
ATOM   3451 O O   . HIS B 1 194 ? -70.651  57.792 24.334  1.00 46.12  ? 1044 HIS B O   1 
ATOM   3452 C CB  . HIS B 1 194 ? -67.853  58.119 24.168  1.00 41.78  ? 1044 HIS B CB  1 
ATOM   3453 C CG  . HIS B 1 194 ? -66.707  59.077 24.294  1.00 44.64  ? 1044 HIS B CG  1 
ATOM   3454 N ND1 . HIS B 1 194 ? -65.959  59.493 23.214  1.00 47.72  ? 1044 HIS B ND1 1 
ATOM   3455 C CD2 . HIS B 1 194 ? -66.177  59.695 25.377  1.00 44.63  ? 1044 HIS B CD2 1 
ATOM   3456 C CE1 . HIS B 1 194 ? -65.018  60.324 23.625  1.00 52.45  ? 1044 HIS B CE1 1 
ATOM   3457 N NE2 . HIS B 1 194 ? -65.128  60.465 24.933  1.00 49.36  ? 1044 HIS B NE2 1 
ATOM   3458 N N   . GLY B 1 195 ? -70.448  56.389 26.074  1.00 36.06  ? 1045 GLY B N   1 
ATOM   3459 C CA  . GLY B 1 195 ? -71.806  55.917 25.941  1.00 38.87  ? 1045 GLY B CA  1 
ATOM   3460 C C   . GLY B 1 195 ? -72.796  56.858 26.595  1.00 41.49  ? 1045 GLY B C   1 
ATOM   3461 O O   . GLY B 1 195 ? -72.458  57.939 27.077  1.00 37.73  ? 1045 GLY B O   1 
ATOM   3462 N N   . LEU B 1 196 ? -74.059  56.439 26.586  1.00 42.13  ? 1046 LEU B N   1 
ATOM   3463 C CA  . LEU B 1 196 ? -75.135  57.221 27.183  1.00 41.81  ? 1046 LEU B CA  1 
ATOM   3464 C C   . LEU B 1 196 ? -75.305  56.756 28.625  1.00 46.40  ? 1046 LEU B C   1 
ATOM   3465 O O   . LEU B 1 196 ? -75.816  55.659 28.872  1.00 47.36  ? 1046 LEU B O   1 
ATOM   3466 C CB  . LEU B 1 196 ? -76.418  57.043 26.377  1.00 42.24  ? 1046 LEU B CB  1 
ATOM   3467 C CG  . LEU B 1 196 ? -77.647  57.832 26.816  1.00 50.08  ? 1046 LEU B CG  1 
ATOM   3468 C CD1 . LEU B 1 196 ? -77.408  59.332 26.723  1.00 42.91  ? 1046 LEU B CD1 1 
ATOM   3469 C CD2 . LEU B 1 196 ? -78.834  57.418 25.975  1.00 50.59  ? 1046 LEU B CD2 1 
ATOM   3470 N N   . TYR B 1 197 ? -74.953  57.619 29.576  1.00 47.05  ? 1047 TYR B N   1 
ATOM   3471 C CA  . TYR B 1 197 ? -75.051  57.308 30.996  1.00 47.73  ? 1047 TYR B CA  1 
ATOM   3472 C C   . TYR B 1 197 ? -75.896  58.338 31.727  1.00 50.82  ? 1047 TYR B C   1 
ATOM   3473 O O   . TYR B 1 197 ? -75.801  59.540 31.461  1.00 54.40  ? 1047 TYR B O   1 
ATOM   3474 C CB  . TYR B 1 197 ? -73.668  57.245 31.654  1.00 44.22  ? 1047 TYR B CB  1 
ATOM   3475 C CG  . TYR B 1 197 ? -72.633  56.550 30.813  1.00 49.26  ? 1047 TYR B CG  1 
ATOM   3476 C CD1 . TYR B 1 197 ? -72.596  55.167 30.724  1.00 57.81  ? 1047 TYR B CD1 1 
ATOM   3477 C CD2 . TYR B 1 197 ? -71.696  57.281 30.100  1.00 51.81  ? 1047 TYR B CD2 1 
ATOM   3478 C CE1 . TYR B 1 197 ? -71.653  54.531 29.948  1.00 47.51  ? 1047 TYR B CE1 1 
ATOM   3479 C CE2 . TYR B 1 197 ? -70.749  56.656 29.325  1.00 52.90  ? 1047 TYR B CE2 1 
ATOM   3480 C CZ  . TYR B 1 197 ? -70.733  55.281 29.251  1.00 51.60  ? 1047 TYR B CZ  1 
ATOM   3481 O OH  . TYR B 1 197 ? -69.793  54.650 28.473  1.00 52.07  ? 1047 TYR B OH  1 
ATOM   3482 N N   . LEU B 1 198 ? -76.688  57.855 32.678  1.00 48.90  ? 1048 LEU B N   1 
ATOM   3483 C CA  . LEU B 1 198 ? -77.532  58.681 33.520  1.00 43.55  ? 1048 LEU B CA  1 
ATOM   3484 C C   . LEU B 1 198 ? -77.063  58.559 34.965  1.00 43.79  ? 1048 LEU B C   1 
ATOM   3485 O O   . LEU B 1 198 ? -76.556  57.504 35.369  1.00 41.25  ? 1048 LEU B O   1 
ATOM   3486 C CB  . LEU B 1 198 ? -79.007  58.262 33.425  1.00 45.44  ? 1048 LEU B CB  1 
ATOM   3487 C CG  . LEU B 1 198 ? -79.874  58.776 32.269  1.00 55.56  ? 1048 LEU B CG  1 
ATOM   3488 C CD1 . LEU B 1 198 ? -79.215  58.575 30.914  1.00 56.16  ? 1048 LEU B CD1 1 
ATOM   3489 C CD2 . LEU B 1 198 ? -81.236  58.097 32.292  1.00 55.10  ? 1048 LEU B CD2 1 
ATOM   3490 N N   . PRO B 1 199 ? -77.188  59.627 35.758  1.00 43.91  ? 1049 PRO B N   1 
ATOM   3491 C CA  . PRO B 1 199 ? -76.767  59.549 37.161  1.00 37.73  ? 1049 PRO B CA  1 
ATOM   3492 C C   . PRO B 1 199 ? -77.641  58.591 37.949  1.00 35.57  ? 1049 PRO B C   1 
ATOM   3493 O O   . PRO B 1 199 ? -78.867  58.584 37.814  1.00 36.44  ? 1049 PRO B O   1 
ATOM   3494 C CB  . PRO B 1 199 ? -76.931  60.990 37.665  1.00 42.62  ? 1049 PRO B CB  1 
ATOM   3495 C CG  . PRO B 1 199 ? -76.930  61.831 36.434  1.00 42.24  ? 1049 PRO B CG  1 
ATOM   3496 C CD  . PRO B 1 199 ? -77.618  60.989 35.398  1.00 44.22  ? 1049 PRO B CD  1 
ATOM   3497 N N   . THR B 1 200 ? -76.999  57.783 38.792  1.00 34.20  ? 1050 THR B N   1 
ATOM   3498 C CA  . THR B 1 200 ? -77.716  56.922 39.718  1.00 33.87  ? 1050 THR B CA  1 
ATOM   3499 C C   . THR B 1 200 ? -77.353  57.165 41.174  1.00 32.57  ? 1050 THR B C   1 
ATOM   3500 O O   . THR B 1 200 ? -78.136  56.789 42.053  1.00 31.76  ? 1050 THR B O   1 
ATOM   3501 C CB  . THR B 1 200 ? -77.486  55.436 39.390  1.00 40.16  ? 1050 THR B CB  1 
ATOM   3502 O OG1 . THR B 1 200 ? -76.120  55.089 39.641  1.00 37.57  ? 1050 THR B OG1 1 
ATOM   3503 C CG2 . THR B 1 200 ? -77.831  55.139 37.935  1.00 40.39  ? 1050 THR B CG2 1 
ATOM   3504 N N   . ARG B 1 201 ? -76.201  57.775 41.455  1.00 30.51  ? 1051 ARG B N   1 
ATOM   3505 C CA  . ARG B 1 201 ? -75.770  58.036 42.821  1.00 30.12  ? 1051 ARG B CA  1 
ATOM   3506 C C   . ARG B 1 201 ? -74.935  59.306 42.848  1.00 34.25  ? 1051 ARG B C   1 
ATOM   3507 O O   . ARG B 1 201 ? -74.184  59.589 41.911  1.00 34.22  ? 1051 ARG B O   1 
ATOM   3508 C CB  . ARG B 1 201 ? -74.926  56.891 43.387  1.00 34.58  ? 1051 ARG B CB  1 
ATOM   3509 C CG  . ARG B 1 201 ? -75.692  55.654 43.777  1.00 42.50  ? 1051 ARG B CG  1 
ATOM   3510 C CD  . ARG B 1 201 ? -74.819  54.738 44.608  1.00 46.05  ? 1051 ARG B CD  1 
ATOM   3511 N NE  . ARG B 1 201 ? -73.628  54.293 43.896  1.00 51.00  ? 1051 ARG B NE  1 
ATOM   3512 C CZ  . ARG B 1 201 ? -73.567  53.208 43.137  1.00 51.28  ? 1051 ARG B CZ  1 
ATOM   3513 N NH1 . ARG B 1 201 ? -74.626  52.439 42.942  1.00 52.88  ? 1051 ARG B NH1 1 
ATOM   3514 N NH2 . ARG B 1 201 ? -72.411  52.883 42.564  1.00 56.07  ? 1051 ARG B NH2 1 
ATOM   3515 N N   . VAL B 1 202 ? -75.066  60.070 43.933  1.00 29.17  ? 1052 VAL B N   1 
ATOM   3516 C CA  . VAL B 1 202 ? -74.181  61.199 44.204  1.00 31.12  ? 1052 VAL B CA  1 
ATOM   3517 C C   . VAL B 1 202 ? -73.865  61.193 45.693  1.00 31.63  ? 1052 VAL B C   1 
ATOM   3518 O O   . VAL B 1 202 ? -74.780  61.245 46.522  1.00 30.90  ? 1052 VAL B O   1 
ATOM   3519 C CB  . VAL B 1 202 ? -74.787  62.558 43.807  1.00 30.08  ? 1052 VAL B CB  1 
ATOM   3520 C CG1 . VAL B 1 202 ? -73.706  63.630 43.826  1.00 30.61  ? 1052 VAL B CG1 1 
ATOM   3521 C CG2 . VAL B 1 202 ? -75.474  62.495 42.448  1.00 33.23  ? 1052 VAL B CG2 1 
ATOM   3522 N N   . THR B 1 203 ? -72.576  61.147 46.035  1.00 30.28  ? 1053 THR B N   1 
ATOM   3523 C CA  . THR B 1 203 ? -72.194  61.049 47.439  1.00 30.91  ? 1053 THR B CA  1 
ATOM   3524 C C   . THR B 1 203 ? -72.511  62.332 48.196  1.00 30.20  ? 1053 THR B C   1 
ATOM   3525 O O   . THR B 1 203 ? -73.050  62.281 49.308  1.00 29.58  ? 1053 THR B O   1 
ATOM   3526 C CB  . THR B 1 203 ? -70.709  60.705 47.564  1.00 33.91  ? 1053 THR B CB  1 
ATOM   3527 O OG1 . THR B 1 203 ? -70.436  59.500 46.840  1.00 34.07  ? 1053 THR B OG1 1 
ATOM   3528 C CG2 . THR B 1 203 ? -70.325  60.510 49.025  1.00 36.11  ? 1053 THR B CG2 1 
ATOM   3529 N N   . ALA B 1 204 ? -72.191  63.492 47.622  1.00 30.15  ? 1054 ALA B N   1 
ATOM   3530 C CA  . ALA B 1 204 ? -72.471  64.727 48.340  1.00 28.60  ? 1054 ALA B CA  1 
ATOM   3531 C C   . ALA B 1 204 ? -72.555  65.903 47.379  1.00 31.99  ? 1054 ALA B C   1 
ATOM   3532 O O   . ALA B 1 204 ? -71.774  66.004 46.437  1.00 32.75  ? 1054 ALA B O   1 
ATOM   3533 C CB  . ALA B 1 204 ? -71.400  65.001 49.403  1.00 31.50  ? 1054 ALA B CB  1 
ATOM   3534 N N   . ILE B 1 205 ? -73.498  66.799 47.634  1.00 27.61  ? 1055 ILE B N   1 
ATOM   3535 C CA  . ILE B 1 205 ? -73.591  68.057 46.908  1.00 27.91  ? 1055 ILE B CA  1 
ATOM   3536 C C   . ILE B 1 205 ? -73.727  69.171 47.932  1.00 29.66  ? 1055 ILE B C   1 
ATOM   3537 O O   . ILE B 1 205 ? -74.617  69.128 48.785  1.00 29.88  ? 1055 ILE B O   1 
ATOM   3538 C CB  . ILE B 1 205 ? -74.774  68.077 45.920  1.00 28.09  ? 1055 ILE B CB  1 
ATOM   3539 C CG1 . ILE B 1 205 ? -74.630  66.946 44.904  1.00 27.42  ? 1055 ILE B CG1 1 
ATOM   3540 C CG2 . ILE B 1 205 ? -74.839  69.417 45.198  1.00 25.60  ? 1055 ILE B CG2 1 
ATOM   3541 C CD1 . ILE B 1 205 ? -75.936  66.478 44.326  1.00 37.04  ? 1055 ILE B CD1 1 
ATOM   3542 N N   . HIS B 1 206 ? -72.847  70.160 47.852  1.00 29.12  ? 1056 HIS B N   1 
ATOM   3543 C CA  . HIS B 1 206 ? -72.932  71.347 48.689  1.00 29.55  ? 1056 HIS B CA  1 
ATOM   3544 C C   . HIS B 1 206 ? -73.317  72.526 47.811  1.00 30.87  ? 1056 HIS B C   1 
ATOM   3545 O O   . HIS B 1 206 ? -72.744  72.710 46.730  1.00 32.65  ? 1056 HIS B O   1 
ATOM   3546 C CB  . HIS B 1 206 ? -71.606  71.645 49.397  1.00 29.84  ? 1056 HIS B CB  1 
ATOM   3547 C CG  . HIS B 1 206 ? -71.210  70.627 50.421  1.00 30.00  ? 1056 HIS B CG  1 
ATOM   3548 N ND1 . HIS B 1 206 ? -70.847  69.338 50.093  1.00 32.65  ? 1056 HIS B ND1 1 
ATOM   3549 C CD2 . HIS B 1 206 ? -71.117  70.711 51.770  1.00 31.39  ? 1056 HIS B CD2 1 
ATOM   3550 C CE1 . HIS B 1 206 ? -70.546  68.674 51.195  1.00 33.00  ? 1056 HIS B CE1 1 
ATOM   3551 N NE2 . HIS B 1 206 ? -70.703  69.484 52.226  1.00 33.35  ? 1056 HIS B NE2 1 
ATOM   3552 N N   . ILE B 1 207 ? -74.281  73.322 48.272  1.00 26.69  ? 1057 ILE B N   1 
ATOM   3553 C CA  . ILE B 1 207 ? -74.674  74.548 47.589  1.00 28.09  ? 1057 ILE B CA  1 
ATOM   3554 C C   . ILE B 1 207 ? -74.659  75.681 48.601  1.00 30.69  ? 1057 ILE B C   1 
ATOM   3555 O O   . ILE B 1 207 ? -75.327  75.601 49.638  1.00 32.94  ? 1057 ILE B O   1 
ATOM   3556 C CB  . ILE B 1 207 ? -76.070  74.450 46.944  1.00 27.61  ? 1057 ILE B CB  1 
ATOM   3557 C CG1 . ILE B 1 207 ? -76.180  73.240 46.017  1.00 31.09  ? 1057 ILE B CG1 1 
ATOM   3558 C CG2 . ILE B 1 207 ? -76.376  75.725 46.175  1.00 29.07  ? 1057 ILE B CG2 1 
ATOM   3559 C CD1 . ILE B 1 207 ? -77.608  72.952 45.585  1.00 32.54  ? 1057 ILE B CD1 1 
ATOM   3560 N N   . ASP B 1 208 ? -73.961  76.758 48.266  1.00 30.39  ? 1058 ASP B N   1 
ATOM   3561 C CA  . ASP B 1 208 ? -73.958  77.969 49.108  1.00 29.44  ? 1058 ASP B CA  1 
ATOM   3562 C C   . ASP B 1 208 ? -74.254  79.157 48.199  1.00 33.51  ? 1058 ASP B C   1 
ATOM   3563 O O   . ASP B 1 208 ? -73.369  79.575 47.476  1.00 32.09  ? 1058 ASP B O   1 
ATOM   3564 C CB  . ASP B 1 208 ? -72.632  78.198 49.813  1.00 33.59  ? 1058 ASP B CB  1 
ATOM   3565 C CG  . ASP B 1 208 ? -72.593  79.487 50.606  1.00 41.39  ? 1058 ASP B CG  1 
ATOM   3566 O OD1 . ASP B 1 208 ? -73.665  80.040 50.856  1.00 42.20  ? 1058 ASP B OD1 1 
ATOM   3567 O OD2 . ASP B 1 208 ? -71.489  79.936 50.928  1.00 39.22  ? 1058 ASP B OD2 1 
ATOM   3568 N N   . PRO B 1 209 ? -75.493  79.663 48.188  1.00 33.75  ? 1059 PRO B N   1 
ATOM   3569 C CA  . PRO B 1 209 ? -75.864  80.757 47.299  1.00 31.68  ? 1059 PRO B CA  1 
ATOM   3570 C C   . PRO B 1 209 ? -74.978  82.001 47.442  1.00 37.60  ? 1059 PRO B C   1 
ATOM   3571 O O   . PRO B 1 209 ? -74.751  82.665 46.486  1.00 36.50  ? 1059 PRO B O   1 
ATOM   3572 C CB  . PRO B 1 209 ? -77.296  81.042 47.752  1.00 37.67  ? 1059 PRO B CB  1 
ATOM   3573 C CG  . PRO B 1 209 ? -77.797  79.708 48.225  1.00 42.23  ? 1059 PRO B CG  1 
ATOM   3574 C CD  . PRO B 1 209 ? -76.611  79.149 48.973  1.00 35.92  ? 1059 PRO B CD  1 
ATOM   3575 N N   . ALA B 1 210 ? -74.486  82.249 48.644  1.00 37.41  ? 1060 ALA B N   1 
ATOM   3576 C CA  . ALA B 1 210 ? -73.669  83.455 48.891  1.00 39.93  ? 1060 ALA B CA  1 
ATOM   3577 C C   . ALA B 1 210 ? -72.341  83.361 48.151  1.00 37.23  ? 1060 ALA B C   1 
ATOM   3578 O O   . ALA B 1 210 ? -71.986  84.301 47.457  1.00 42.58  ? 1060 ALA B O   1 
ATOM   3579 C CB  . ALA B 1 210 ? -73.468  83.612 50.368  1.00 42.84  ? 1060 ALA B CB  1 
ATOM   3580 N N   . THR B 1 211 ? -71.650  82.253 48.310  1.00 35.42  ? 1061 THR B N   1 
ATOM   3581 C CA  . THR B 1 211 ? -70.393  82.042 47.563  1.00 37.75  ? 1061 THR B CA  1 
ATOM   3582 C C   . THR B 1 211 ? -70.715  82.097 46.070  1.00 38.72  ? 1061 THR B C   1 
ATOM   3583 O O   . THR B 1 211 ? -69.930  82.676 45.333  1.00 39.33  ? 1061 THR B O   1 
ATOM   3584 C CB  . THR B 1 211 ? -69.711  80.744 48.005  1.00 35.68  ? 1061 THR B CB  1 
ATOM   3585 O OG1 . THR B 1 211 ? -69.395  80.838 49.392  1.00 40.65  ? 1061 THR B OG1 1 
ATOM   3586 C CG2 . THR B 1 211 ? -68.463  80.439 47.209  1.00 38.85  ? 1061 THR B CG2 1 
ATOM   3587 N N   . HIS B 1 212 ? -71.859  81.549 45.668  1.00 30.81  ? 1062 HIS B N   1 
ATOM   3588 C CA  . HIS B 1 212 ? -72.237  81.510 44.235  1.00 31.29  ? 1062 HIS B CA  1 
ATOM   3589 C C   . HIS B 1 212 ? -72.282  82.934 43.672  1.00 41.09  ? 1062 HIS B C   1 
ATOM   3590 O O   . HIS B 1 212 ? -71.693  83.209 42.633  1.00 38.26  ? 1062 HIS B O   1 
ATOM   3591 C CB  . HIS B 1 212 ? -73.583  80.805 44.058  1.00 32.30  ? 1062 HIS B CB  1 
ATOM   3592 C CG  . HIS B 1 212 ? -73.994  80.550 42.651  1.00 32.39  ? 1062 HIS B CG  1 
ATOM   3593 N ND1 . HIS B 1 212 ? -73.365  79.638 41.837  1.00 32.82  ? 1062 HIS B ND1 1 
ATOM   3594 C CD2 . HIS B 1 212 ? -74.998  81.051 41.938  1.00 29.32  ? 1062 HIS B CD2 1 
ATOM   3595 C CE1 . HIS B 1 212 ? -73.968  79.620 40.662  1.00 35.82  ? 1062 HIS B CE1 1 
ATOM   3596 N NE2 . HIS B 1 212 ? -74.961  80.472 40.702  1.00 34.41  ? 1062 HIS B NE2 1 
ATOM   3597 N N   . ARG B 1 213 ? -72.967  83.817 44.383  1.00 37.90  ? 1063 ARG B N   1 
ATOM   3598 C CA  . ARG B 1 213 ? -73.101  85.218 43.924  1.00 39.68  ? 1063 ARG B CA  1 
ATOM   3599 C C   . ARG B 1 213 ? -71.714  85.862 43.830  1.00 43.29  ? 1063 ARG B C   1 
ATOM   3600 O O   . ARG B 1 213 ? -71.504  86.654 42.928  1.00 44.55  ? 1063 ARG B O   1 
ATOM   3601 C CB  . ARG B 1 213 ? -74.016  85.976 44.883  1.00 39.27  ? 1063 ARG B CB  1 
ATOM   3602 C CG  . ARG B 1 213 ? -75.398  85.385 45.091  1.00 50.71  ? 1063 ARG B CG  1 
ATOM   3603 C CD  . ARG B 1 213 ? -76.200  86.428 45.842  1.00 55.46  ? 1063 ARG B CD  1 
ATOM   3604 N NE  . ARG B 1 213 ? -77.452  85.945 46.393  1.00 65.32  ? 1063 ARG B NE  1 
ATOM   3605 C CZ  . ARG B 1 213 ? -77.552  85.062 47.378  1.00 56.69  ? 1063 ARG B CZ  1 
ATOM   3606 N NH1 . ARG B 1 213 ? -76.788  85.175 48.448  1.00 47.91  ? 1063 ARG B NH1 1 
ATOM   3607 N NH2 . ARG B 1 213 ? -78.443  84.092 47.297  1.00 52.69  ? 1063 ARG B NH2 1 
ATOM   3608 N N   . GLN B 1 214 ? -70.815  85.502 44.731  1.00 44.41  ? 1064 GLN B N   1 
ATOM   3609 C CA  . GLN B 1 214 ? -69.439  86.051 44.733  1.00 47.19  ? 1064 GLN B CA  1 
ATOM   3610 C C   . GLN B 1 214 ? -68.605  85.444 43.602  1.00 46.94  ? 1064 GLN B C   1 
ATOM   3611 O O   . GLN B 1 214 ? -67.693  86.125 43.135  1.00 48.32  ? 1064 GLN B O   1 
ATOM   3612 C CB  . GLN B 1 214 ? -68.796  85.828 46.100  1.00 46.31  ? 1064 GLN B CB  1 
ATOM   3613 C CG  . GLN B 1 214 ? -69.458  86.621 47.218  1.00 54.53  ? 1064 GLN B CG  1 
ATOM   3614 C CD  . GLN B 1 214 ? -69.635  88.085 46.892  1.00 66.07  ? 1064 GLN B CD  1 
ATOM   3615 O OE1 . GLN B 1 214 ? -70.748  88.606 46.864  1.00 64.32  ? 1064 GLN B OE1 1 
ATOM   3616 N NE2 . GLN B 1 214 ? -68.531  88.769 46.643  1.00 65.19  ? 1064 GLN B NE2 1 
ATOM   3617 N N   . LYS B 1 215 ? -68.902  84.224 43.183  1.00 39.56  ? 1065 LYS B N   1 
ATOM   3618 C CA  . LYS B 1 215 ? -68.070  83.550 42.159  1.00 38.43  ? 1065 LYS B CA  1 
ATOM   3619 C C   . LYS B 1 215 ? -68.515  83.959 40.753  1.00 39.79  ? 1065 LYS B C   1 
ATOM   3620 O O   . LYS B 1 215 ? -67.705  83.869 39.841  1.00 42.46  ? 1065 LYS B O   1 
ATOM   3621 C CB  . LYS B 1 215 ? -68.118  82.032 42.349  1.00 37.00  ? 1065 LYS B CB  1 
ATOM   3622 C CG  . LYS B 1 215 ? -67.345  81.478 43.536  1.00 40.14  ? 1065 LYS B CG  1 
ATOM   3623 C CD  . LYS B 1 215 ? -65.866  81.327 43.274  1.00 44.99  ? 1065 LYS B CD  1 
ATOM   3624 C CE  . LYS B 1 215 ? -65.181  80.418 44.269  1.00 48.39  ? 1065 LYS B CE  1 
ATOM   3625 N NZ  . LYS B 1 215 ? -63.730  80.304 44.002  1.00 51.38  ? 1065 LYS B NZ  1 
ATOM   3626 N N   . LEU B 1 216 ? -69.759  84.389 40.604  1.00 38.80  ? 1066 LEU B N   1 
ATOM   3627 C CA  . LEU B 1 216 ? -70.222  84.806 39.293  1.00 39.60  ? 1066 LEU B CA  1 
ATOM   3628 C C   . LEU B 1 216 ? -69.449  86.034 38.835  1.00 44.13  ? 1066 LEU B C   1 
ATOM   3629 O O   . LEU B 1 216 ? -69.017  86.860 39.643  1.00 45.73  ? 1066 LEU B O   1 
ATOM   3630 C CB  . LEU B 1 216 ? -71.717  85.117 39.333  1.00 41.66  ? 1066 LEU B CB  1 
ATOM   3631 C CG  . LEU B 1 216 ? -72.656  83.920 39.478  1.00 37.84  ? 1066 LEU B CG  1 
ATOM   3632 C CD1 . LEU B 1 216 ? -74.090  84.388 39.665  1.00 42.37  ? 1066 LEU B CD1 1 
ATOM   3633 C CD2 . LEU B 1 216 ? -72.534  83.008 38.272  1.00 35.51  ? 1066 LEU B CD2 1 
ATOM   3634 N N   . TYR B 1 217 ? -69.232  86.113 37.523  1.00 45.02  ? 1067 TYR B N   1 
ATOM   3635 C CA  . TYR B 1 217 ? -68.569  87.287 36.908  1.00 47.84  ? 1067 TYR B CA  1 
ATOM   3636 C C   . TYR B 1 217 ? -69.286  87.593 35.595  1.00 49.17  ? 1067 TYR B C   1 
ATOM   3637 O O   . TYR B 1 217 ? -69.941  86.713 35.051  1.00 43.71  ? 1067 TYR B O   1 
ATOM   3638 C CB  . TYR B 1 217 ? -67.057  87.120 36.769  1.00 43.55  ? 1067 TYR B CB  1 
ATOM   3639 C CG  . TYR B 1 217 ? -66.520  86.028 35.889  1.00 50.03  ? 1067 TYR B CG  1 
ATOM   3640 C CD1 . TYR B 1 217 ? -66.334  84.747 36.372  1.00 44.36  ? 1067 TYR B CD1 1 
ATOM   3641 C CD2 . TYR B 1 217 ? -66.115  86.301 34.597  1.00 45.77  ? 1067 TYR B CD2 1 
ATOM   3642 C CE1 . TYR B 1 217 ? -65.797  83.754 35.575  1.00 42.47  ? 1067 TYR B CE1 1 
ATOM   3643 C CE2 . TYR B 1 217 ? -65.582  85.318 33.786  1.00 47.31  ? 1067 TYR B CE2 1 
ATOM   3644 C CZ  . TYR B 1 217 ? -65.425  84.038 34.276  1.00 49.27  ? 1067 TYR B CZ  1 
ATOM   3645 O OH  . TYR B 1 217 ? -64.896  83.069 33.467  1.00 48.04  ? 1067 TYR B OH  1 
ATOM   3646 N N   . THR B 1 218 ? -69.182  88.837 35.137  1.00 49.65  ? 1068 THR B N   1 
ATOM   3647 C CA  . THR B 1 218 ? -69.946  89.265 33.938  1.00 47.99  ? 1068 THR B CA  1 
ATOM   3648 C C   . THR B 1 218 ? -69.001  89.476 32.764  1.00 51.27  ? 1068 THR B C   1 
ATOM   3649 O O   . THR B 1 218 ? -67.915  90.004 32.969  1.00 55.35  ? 1068 THR B O   1 
ATOM   3650 C CB  . THR B 1 218 ? -70.767  90.527 34.216  1.00 54.84  ? 1068 THR B CB  1 
ATOM   3651 O OG1 . THR B 1 218 ? -71.567  90.302 35.376  1.00 61.75  ? 1068 THR B OG1 1 
ATOM   3652 C CG2 . THR B 1 218 ? -71.657  90.916 33.059  1.00 55.80  ? 1068 THR B CG2 1 
ATOM   3653 N N   . LEU B 1 219 ? -69.423  89.038 31.589  1.00 52.89  ? 1069 LEU B N   1 
ATOM   3654 C CA  . LEU B 1 219 ? -68.607  89.216 30.372  1.00 57.70  ? 1069 LEU B CA  1 
ATOM   3655 C C   . LEU B 1 219 ? -69.005  90.541 29.702  1.00 64.19  ? 1069 LEU B C   1 
ATOM   3656 O O   . LEU B 1 219 ? -69.989  91.152 30.129  1.00 57.59  ? 1069 LEU B O   1 
ATOM   3657 C CB  . LEU B 1 219 ? -68.840  88.026 29.444  1.00 57.30  ? 1069 LEU B CB  1 
ATOM   3658 C CG  . LEU B 1 219 ? -68.505  86.651 30.016  1.00 52.57  ? 1069 LEU B CG  1 
ATOM   3659 C CD1 . LEU B 1 219 ? -68.688  85.577 28.959  1.00 48.90  ? 1069 LEU B CD1 1 
ATOM   3660 C CD2 . LEU B 1 219 ? -67.088  86.623 30.555  1.00 53.89  ? 1069 LEU B CD2 1 
ATOM   3661 N N   . GLN B 1 220 ? -68.288  90.922 28.651  1.00 64.50  ? 1070 GLN B N   1 
ATOM   3662 C CA  . GLN B 1 220 ? -68.542  92.220 27.986  1.00 65.00  ? 1070 GLN B CA  1 
ATOM   3663 C C   . GLN B 1 220 ? -69.985  92.295 27.490  1.00 65.49  ? 1070 GLN B C   1 
ATOM   3664 O O   . GLN B 1 220 ? -70.544  93.376 27.549  1.00 71.28  ? 1070 GLN B O   1 
ATOM   3665 C CB  . GLN B 1 220 ? -67.522  92.381 26.865  1.00 69.41  ? 1070 GLN B CB  1 
ATOM   3666 C CG  . GLN B 1 220 ? -67.936  93.369 25.790  1.00 79.91  ? 1070 GLN B CG  1 
ATOM   3667 C CD  . GLN B 1 220 ? -67.867  94.782 26.307  1.00 83.87  ? 1070 GLN B CD  1 
ATOM   3668 O OE1 . GLN B 1 220 ? -67.475  95.025 27.446  1.00 82.85  ? 1070 GLN B OE1 1 
ATOM   3669 N NE2 . GLN B 1 220 ? -68.243  95.728 25.464  1.00 86.54  ? 1070 GLN B NE2 1 
ATOM   3670 N N   . ASP B 1 221 ? -70.558  91.182 27.039  1.00 64.97  ? 1071 ASP B N   1 
ATOM   3671 C CA  . ASP B 1 221 ? -71.950  91.167 26.532  1.00 61.45  ? 1071 ASP B CA  1 
ATOM   3672 C C   . ASP B 1 221 ? -72.947  91.197 27.686  1.00 66.77  ? 1071 ASP B C   1 
ATOM   3673 O O   . ASP B 1 221 ? -74.132  91.104 27.397  1.00 66.98  ? 1071 ASP B O   1 
ATOM   3674 C CB  . ASP B 1 221 ? -72.236  89.955 25.654  1.00 64.56  ? 1071 ASP B CB  1 
ATOM   3675 C CG  . ASP B 1 221 ? -72.119  88.626 26.368  1.00 66.71  ? 1071 ASP B CG  1 
ATOM   3676 O OD1 . ASP B 1 221 ? -71.754  88.627 27.552  1.00 65.03  ? 1071 ASP B OD1 1 
ATOM   3677 O OD2 . ASP B 1 221 ? -72.399  87.606 25.725  1.00 67.69  ? 1071 ASP B OD2 1 
ATOM   3678 N N   . LYS B 1 222 ? -72.467  91.276 28.930  1.00 64.30  ? 1072 LYS B N   1 
ATOM   3679 C CA  . LYS B 1 222 ? -73.355  91.359 30.118  1.00 63.87  ? 1072 LYS B CA  1 
ATOM   3680 C C   . LYS B 1 222 ? -73.810  89.972 30.590  1.00 60.77  ? 1072 LYS B C   1 
ATOM   3681 O O   . LYS B 1 222 ? -74.561  89.902 31.563  1.00 62.38  ? 1072 LYS B O   1 
ATOM   3682 C CB  . LYS B 1 222 ? -74.572  92.237 29.829  1.00 70.29  ? 1072 LYS B CB  1 
ATOM   3683 C CG  . LYS B 1 222 ? -74.256  93.723 29.749  1.00 72.99  ? 1072 LYS B CG  1 
ATOM   3684 C CD  . LYS B 1 222 ? -73.405  94.196 30.908  1.00 71.23  ? 1072 LYS B CD  1 
ATOM   3685 C CE  . LYS B 1 222 ? -72.977  95.644 30.784  1.00 77.48  ? 1072 LYS B CE  1 
ATOM   3686 N NZ  . LYS B 1 222 ? -71.971  96.009 31.810  1.00 75.83  ? 1072 LYS B NZ  1 
ATOM   3687 N N   . ALA B 1 223 ? -73.374  88.923 29.922  1.00 57.51  ? 1073 ALA B N   1 
ATOM   3688 C CA  . ALA B 1 223 ? -73.706  87.569 30.395  1.00 56.87  ? 1073 ALA B CA  1 
ATOM   3689 C C   . ALA B 1 223 ? -72.995  87.279 31.715  1.00 55.04  ? 1073 ALA B C   1 
ATOM   3690 O O   . ALA B 1 223 ? -71.860  87.726 31.876  1.00 50.68  ? 1073 ALA B O   1 
ATOM   3691 C CB  . ALA B 1 223 ? -73.304  86.572 29.359  1.00 54.63  ? 1073 ALA B CB  1 
ATOM   3692 N N   . GLN B 1 224 ? -73.654  86.526 32.600  1.00 50.37  ? 1074 GLN B N   1 
ATOM   3693 C CA  . GLN B 1 224 ? -73.040  86.108 33.879  1.00 45.33  ? 1074 GLN B CA  1 
ATOM   3694 C C   . GLN B 1 224 ? -72.566  84.671 33.715  1.00 40.72  ? 1074 GLN B C   1 
ATOM   3695 O O   . GLN B 1 224 ? -73.265  83.892 33.093  1.00 38.98  ? 1074 GLN B O   1 
ATOM   3696 C CB  . GLN B 1 224 ? -74.003  86.271 35.050  1.00 48.26  ? 1074 GLN B CB  1 
ATOM   3697 C CG  . GLN B 1 224 ? -74.504  87.685 35.265  1.00 48.72  ? 1074 GLN B CG  1 
ATOM   3698 C CD  . GLN B 1 224 ? -75.550  87.690 36.347  1.00 45.62  ? 1074 GLN B CD  1 
ATOM   3699 O OE1 . GLN B 1 224 ? -75.266  87.438 37.512  1.00 49.83  ? 1074 GLN B OE1 1 
ATOM   3700 N NE2 . GLN B 1 224 ? -76.781  87.972 35.962  1.00 61.58  ? 1074 GLN B NE2 1 
ATOM   3701 N N   . VAL B 1 225 ? -71.406  84.383 34.259  1.00 36.00  ? 1075 VAL B N   1 
ATOM   3702 C CA  . VAL B 1 225 ? -70.779  83.079 34.082  1.00 39.28  ? 1075 VAL B CA  1 
ATOM   3703 C C   . VAL B 1 225 ? -70.068  82.676 35.365  1.00 39.77  ? 1075 VAL B C   1 
ATOM   3704 O O   . VAL B 1 225 ? -69.784  83.502 36.234  1.00 38.98  ? 1075 VAL B O   1 
ATOM   3705 C CB  . VAL B 1 225 ? -69.766  83.078 32.911  1.00 41.64  ? 1075 VAL B CB  1 
ATOM   3706 C CG1 . VAL B 1 225 ? -70.466  83.283 31.570  1.00 41.46  ? 1075 VAL B CG1 1 
ATOM   3707 C CG2 . VAL B 1 225 ? -68.702  84.133 33.141  1.00 45.83  ? 1075 VAL B CG2 1 
ATOM   3708 N N   . ALA B 1 226 ? -69.782  81.384 35.472  1.00 36.40  ? 1076 ALA B N   1 
ATOM   3709 C CA  . ALA B 1 226 ? -68.929  80.833 36.511  1.00 35.55  ? 1076 ALA B CA  1 
ATOM   3710 C C   . ALA B 1 226 ? -67.952  79.846 35.892  1.00 31.87  ? 1076 ALA B C   1 
ATOM   3711 O O   . ALA B 1 226 ? -68.301  79.102 34.971  1.00 37.62  ? 1076 ALA B O   1 
ATOM   3712 C CB  . ALA B 1 226 ? -69.746  80.139 37.605  1.00 39.11  ? 1076 ALA B CB  1 
ATOM   3713 N N   . ASP B 1 227 ? -66.732  79.836 36.413  1.00 35.52  ? 1077 ASP B N   1 
ATOM   3714 C CA  . ASP B 1 227 ? -65.736  78.864 35.996  1.00 35.96  ? 1077 ASP B CA  1 
ATOM   3715 C C   . ASP B 1 227 ? -66.060  77.509 36.612  1.00 37.23  ? 1077 ASP B C   1 
ATOM   3716 O O   . ASP B 1 227 ? -66.444  77.423 37.782  1.00 37.51  ? 1077 ASP B O   1 
ATOM   3717 C CB  . ASP B 1 227 ? -64.350  79.321 36.445  1.00 36.79  ? 1077 ASP B CB  1 
ATOM   3718 C CG  . ASP B 1 227 ? -63.888  80.568 35.726  1.00 43.92  ? 1077 ASP B CG  1 
ATOM   3719 O OD1 . ASP B 1 227 ? -64.422  80.863 34.636  1.00 41.60  ? 1077 ASP B OD1 1 
ATOM   3720 O OD2 . ASP B 1 227 ? -63.032  81.286 36.282  1.00 48.55  ? 1077 ASP B OD2 1 
ATOM   3721 N N   . VAL B 1 228 ? -65.891  76.448 35.826  1.00 34.55  ? 1078 VAL B N   1 
ATOM   3722 C CA  . VAL B 1 228 ? -66.122  75.085 36.290  1.00 34.72  ? 1078 VAL B CA  1 
ATOM   3723 C C   . VAL B 1 228 ? -64.817  74.308 36.178  1.00 41.27  ? 1078 VAL B C   1 
ATOM   3724 O O   . VAL B 1 228 ? -64.048  74.503 35.227  1.00 38.91  ? 1078 VAL B O   1 
ATOM   3725 C CB  . VAL B 1 228 ? -67.252  74.385 35.500  1.00 31.73  ? 1078 VAL B CB  1 
ATOM   3726 C CG1 . VAL B 1 228 ? -66.961  74.394 34.007  1.00 36.35  ? 1078 VAL B CG1 1 
ATOM   3727 C CG2 . VAL B 1 228 ? -67.482  72.959 36.010  1.00 30.89  ? 1078 VAL B CG2 1 
ATOM   3728 N N   . VAL B 1 229 ? -64.570  73.444 37.170  1.00 33.21  ? 1079 VAL B N   1 
ATOM   3729 C CA  . VAL B 1 229 ? -63.431  72.530 37.199  1.00 32.75  ? 1079 VAL B CA  1 
ATOM   3730 C C   . VAL B 1 229 ? -63.931  71.118 37.485  1.00 36.00  ? 1079 VAL B C   1 
ATOM   3731 O O   . VAL B 1 229 ? -64.785  70.916 38.358  1.00 38.02  ? 1079 VAL B O   1 
ATOM   3732 C CB  . VAL B 1 229 ? -62.382  72.948 38.256  1.00 40.23  ? 1079 VAL B CB  1 
ATOM   3733 C CG1 . VAL B 1 229 ? -61.165  72.031 38.199  1.00 46.43  ? 1079 VAL B CG1 1 
ATOM   3734 C CG2 . VAL B 1 229 ? -61.967  74.399 38.068  1.00 43.81  ? 1079 VAL B CG2 1 
ATOM   3735 N N   . VAL B 1 230 ? -63.394  70.141 36.753  1.00 34.61  ? 1080 VAL B N   1 
ATOM   3736 C CA  . VAL B 1 230 ? -63.649  68.720 36.979  1.00 34.61  ? 1080 VAL B CA  1 
ATOM   3737 C C   . VAL B 1 230 ? -62.328  68.070 37.369  1.00 46.06  ? 1080 VAL B C   1 
ATOM   3738 O O   . VAL B 1 230 ? -61.327  68.222 36.661  1.00 37.62  ? 1080 VAL B O   1 
ATOM   3739 C CB  . VAL B 1 230 ? -64.243  68.017 35.743  1.00 36.43  ? 1080 VAL B CB  1 
ATOM   3740 C CG1 . VAL B 1 230 ? -64.457  66.532 36.038  1.00 39.44  ? 1080 VAL B CG1 1 
ATOM   3741 C CG2 . VAL B 1 230 ? -65.544  68.670 35.315  1.00 36.67  ? 1080 VAL B CG2 1 
ATOM   3742 N N   . SER B 1 231 ? -62.324  67.357 38.496  1.00 42.07  ? 1081 SER B N   1 
ATOM   3743 C CA  . SER B 1 231 ? -61.153  66.639 38.994  1.00 41.87  ? 1081 SER B CA  1 
ATOM   3744 C C   . SER B 1 231 ? -61.474  65.151 39.072  1.00 51.39  ? 1081 SER B C   1 
ATOM   3745 O O   . SER B 1 231 ? -62.296  64.727 39.903  1.00 45.82  ? 1081 SER B O   1 
ATOM   3746 C CB  . SER B 1 231 ? -60.710  67.166 40.355  1.00 49.73  ? 1081 SER B CB  1 
ATOM   3747 O OG  . SER B 1 231 ? -59.910  66.201 41.017  1.00 56.56  ? 1081 SER B OG  1 
ATOM   3748 N N   . ARG B 1 232 ? -60.858  64.375 38.168  1.00 46.84  ? 1082 ARG B N   1 
ATOM   3749 C CA  . ARG B 1 232 ? -61.003  62.920 38.188  1.00 52.25  ? 1082 ARG B CA  1 
ATOM   3750 C C   . ARG B 1 232 ? -60.326  62.299 39.401  1.00 55.91  ? 1082 ARG B C   1 
ATOM   3751 O O   . ARG B 1 232 ? -60.846  61.338 39.978  1.00 57.59  ? 1082 ARG B O   1 
ATOM   3752 C CB  . ARG B 1 232 ? -60.415  62.317 36.906  1.00 54.98  ? 1082 ARG B CB  1 
ATOM   3753 C CG  . ARG B 1 232 ? -60.872  63.008 35.638  1.00 62.97  ? 1082 ARG B CG  1 
ATOM   3754 C CD  . ARG B 1 232 ? -62.370  63.185 35.682  1.00 61.53  ? 1082 ARG B CD  1 
ATOM   3755 N NE  . ARG B 1 232 ? -62.972  63.421 34.377  1.00 64.55  ? 1082 ARG B NE  1 
ATOM   3756 C CZ  . ARG B 1 232 ? -64.204  63.057 34.055  1.00 61.76  ? 1082 ARG B CZ  1 
ATOM   3757 N NH1 . ARG B 1 232 ? -64.997  62.459 34.928  1.00 66.60  ? 1082 ARG B NH1 1 
ATOM   3758 N NH2 . ARG B 1 232 ? -64.684  63.383 32.862  1.00 57.63  ? 1082 ARG B NH2 1 
ATOM   3759 N N   . TRP B 1 233 ? -59.168  62.830 39.799  1.00 53.34  ? 1083 TRP B N   1 
ATOM   3760 C CA  . TRP B 1 233 ? -58.485  62.336 40.992  1.00 55.02  ? 1083 TRP B CA  1 
ATOM   3761 C C   . TRP B 1 233 ? -59.406  62.360 42.205  1.00 56.07  ? 1083 TRP B C   1 
ATOM   3762 O O   . TRP B 1 233 ? -59.370  61.451 43.043  1.00 56.62  ? 1083 TRP B O   1 
ATOM   3763 C CB  . TRP B 1 233 ? -57.233  63.165 41.260  1.00 49.63  ? 1083 TRP B CB  1 
ATOM   3764 C CG  . TRP B 1 233 ? -56.081  62.868 40.345  1.00 53.94  ? 1083 TRP B CG  1 
ATOM   3765 C CD1 . TRP B 1 233 ? -55.923  61.786 39.524  1.00 59.33  ? 1083 TRP B CD1 1 
ATOM   3766 C CD2 . TRP B 1 233 ? -54.928  63.689 40.153  1.00 50.49  ? 1083 TRP B CD2 1 
ATOM   3767 N NE1 . TRP B 1 233 ? -54.734  61.888 38.836  1.00 55.84  ? 1083 TRP B NE1 1 
ATOM   3768 C CE2 . TRP B 1 233 ? -54.107  63.048 39.206  1.00 56.13  ? 1083 TRP B CE2 1 
ATOM   3769 C CE3 . TRP B 1 233 ? -54.511  64.907 40.693  1.00 52.95  ? 1083 TRP B CE3 1 
ATOM   3770 C CZ2 . TRP B 1 233 ? -52.890  63.588 38.791  1.00 58.68  ? 1083 TRP B CZ2 1 
ATOM   3771 C CZ3 . TRP B 1 233 ? -53.307  65.439 40.283  1.00 54.77  ? 1083 TRP B CZ3 1 
ATOM   3772 C CH2 . TRP B 1 233 ? -52.510  64.781 39.341  1.00 54.17  ? 1083 TRP B CH2 1 
ATOM   3773 N N   . LEU B 1 234 ? -60.136  63.461 42.381  1.00 47.42  ? 1084 LEU B N   1 
ATOM   3774 C CA  . LEU B 1 234 ? -61.019  63.659 43.520  1.00 47.97  ? 1084 LEU B CA  1 
ATOM   3775 C C   . LEU B 1 234 ? -62.474  63.273 43.264  1.00 46.51  ? 1084 LEU B C   1 
ATOM   3776 O O   . LEU B 1 234 ? -63.242  63.184 44.232  1.00 46.94  ? 1084 LEU B O   1 
ATOM   3777 C CB  . LEU B 1 234 ? -60.973  65.137 43.907  1.00 47.64  ? 1084 LEU B CB  1 
ATOM   3778 C CG  . LEU B 1 234 ? -59.577  65.645 44.262  1.00 55.24  ? 1084 LEU B CG  1 
ATOM   3779 C CD1 . LEU B 1 234 ? -59.633  67.087 44.725  1.00 55.44  ? 1084 LEU B CD1 1 
ATOM   3780 C CD2 . LEU B 1 234 ? -58.955  64.760 45.323  1.00 52.89  ? 1084 LEU B CD2 1 
ATOM   3781 N N   . ARG B 1 235 ? -62.856  62.996 42.011  1.00 41.77  ? 1085 ARG B N   1 
ATOM   3782 C CA  . ARG B 1 235 ? -64.260  62.762 41.645  1.00 42.89  ? 1085 ARG B CA  1 
ATOM   3783 C C   . ARG B 1 235 ? -65.132  63.918 42.117  1.00 43.66  ? 1085 ARG B C   1 
ATOM   3784 O O   . ARG B 1 235 ? -66.122  63.743 42.834  1.00 37.97  ? 1085 ARG B O   1 
ATOM   3785 C CB  . ARG B 1 235 ? -64.771  61.411 42.138  1.00 43.25  ? 1085 ARG B CB  1 
ATOM   3786 C CG  . ARG B 1 235 ? -63.752  60.327 41.937  1.00 47.63  ? 1085 ARG B CG  1 
ATOM   3787 C CD  . ARG B 1 235 ? -64.383  59.016 41.536  1.00 51.85  ? 1085 ARG B CD  1 
ATOM   3788 N NE  . ARG B 1 235 ? -63.352  58.053 41.172  1.00 58.92  ? 1085 ARG B NE  1 
ATOM   3789 C CZ  . ARG B 1 235 ? -63.529  56.741 41.139  1.00 55.09  ? 1085 ARG B CZ  1 
ATOM   3790 N NH1 . ARG B 1 235 ? -64.705  56.196 41.404  1.00 57.18  ? 1085 ARG B NH1 1 
ATOM   3791 N NH2 . ARG B 1 235 ? -62.509  55.958 40.801  1.00 53.21  ? 1085 ARG B NH2 1 
ATOM   3792 N N   . VAL B 1 236 ? -64.731  65.124 41.723  1.00 36.78  ? 1086 VAL B N   1 
ATOM   3793 C CA  . VAL B 1 236 ? -65.401  66.343 42.160  1.00 32.28  ? 1086 VAL B CA  1 
ATOM   3794 C C   . VAL B 1 236 ? -65.574  67.254 40.952  1.00 40.11  ? 1086 VAL B C   1 
ATOM   3795 O O   . VAL B 1 236 ? -64.697  67.326 40.085  1.00 35.18  ? 1086 VAL B O   1 
ATOM   3796 C CB  . VAL B 1 236 ? -64.618  67.056 43.289  1.00 37.59  ? 1086 VAL B CB  1 
ATOM   3797 C CG1 . VAL B 1 236 ? -65.176  68.427 43.538  1.00 39.45  ? 1086 VAL B CG1 1 
ATOM   3798 C CG2 . VAL B 1 236 ? -64.656  66.246 44.580  1.00 37.74  ? 1086 VAL B CG2 1 
ATOM   3799 N N   . THR B 1 237 ? -66.742  67.882 40.849  1.00 32.95  ? 1087 THR B N   1 
ATOM   3800 C CA  . THR B 1 237 ? -66.988  68.955 39.892  1.00 32.73  ? 1087 THR B CA  1 
ATOM   3801 C C   . THR B 1 237 ? -67.438  70.178 40.679  1.00 36.57  ? 1087 THR B C   1 
ATOM   3802 O O   . THR B 1 237 ? -68.352  70.084 41.503  1.00 33.14  ? 1087 THR B O   1 
ATOM   3803 C CB  . THR B 1 237 ? -68.046  68.555 38.847  1.00 33.44  ? 1087 THR B CB  1 
ATOM   3804 O OG1 . THR B 1 237 ? -67.564  67.459 38.058  1.00 34.61  ? 1087 THR B OG1 1 
ATOM   3805 C CG2 . THR B 1 237 ? -68.375  69.726 37.919  1.00 31.42  ? 1087 THR B CG2 1 
ATOM   3806 N N   . VAL B 1 238 ? -66.787  71.319 40.452  1.00 30.92  ? 1088 VAL B N   1 
ATOM   3807 C CA  . VAL B 1 238 ? -67.066  72.531 41.219  1.00 30.79  ? 1088 VAL B CA  1 
ATOM   3808 C C   . VAL B 1 238 ? -67.290  73.684 40.256  1.00 36.08  ? 1088 VAL B C   1 
ATOM   3809 O O   . VAL B 1 238 ? -66.535  73.859 39.293  1.00 30.28  ? 1088 VAL B O   1 
ATOM   3810 C CB  . VAL B 1 238 ? -65.933  72.895 42.204  1.00 36.17  ? 1088 VAL B CB  1 
ATOM   3811 C CG1 . VAL B 1 238 ? -66.338  74.086 43.073  1.00 35.28  ? 1088 VAL B CG1 1 
ATOM   3812 C CG2 . VAL B 1 238 ? -65.576  71.732 43.071  1.00 41.08  ? 1088 VAL B CG2 1 
ATOM   3813 N N   . ALA B 1 239 ? -68.317  74.485 40.538  1.00 31.53  ? 1089 ALA B N   1 
ATOM   3814 C CA  . ALA B 1 239 ? -68.612  75.661 39.728  1.00 33.65  ? 1089 ALA B CA  1 
ATOM   3815 C C   . ALA B 1 239 ? -69.500  76.590 40.538  1.00 36.47  ? 1089 ALA B C   1 
ATOM   3816 O O   . ALA B 1 239 ? -70.484  76.139 41.134  1.00 34.73  ? 1089 ALA B O   1 
ATOM   3817 C CB  . ALA B 1 239 ? -69.297  75.276 38.411  1.00 29.60  ? 1089 ALA B CB  1 
ATOM   3818 N N   . GLY B 1 240 ? -69.154  77.876 40.551  1.00 35.64  ? 1090 GLY B N   1 
ATOM   3819 C CA  . GLY B 1 240 ? -69.900  78.830 41.355  1.00 31.40  ? 1090 GLY B CA  1 
ATOM   3820 C C   . GLY B 1 240 ? -69.936  78.392 42.805  1.00 36.69  ? 1090 GLY B C   1 
ATOM   3821 O O   . GLY B 1 240 ? -68.918  78.004 43.389  1.00 36.65  ? 1090 GLY B O   1 
ATOM   3822 N N   . GLY B 1 241 ? -71.124  78.418 43.393  1.00 29.77  ? 1091 GLY B N   1 
ATOM   3823 C CA  . GLY B 1 241 ? -71.264  77.941 44.750  1.00 31.20  ? 1091 GLY B CA  1 
ATOM   3824 C C   . GLY B 1 241 ? -71.818  76.534 44.818  1.00 31.22  ? 1091 GLY B C   1 
ATOM   3825 O O   . GLY B 1 241 ? -72.560  76.210 45.749  1.00 30.36  ? 1091 GLY B O   1 
ATOM   3826 N N   . VAL B 1 242 ? -71.470  75.683 43.850  1.00 30.75  ? 1092 VAL B N   1 
ATOM   3827 C CA  . VAL B 1 242 ? -71.920  74.294 43.830  1.00 28.08  ? 1092 VAL B CA  1 
ATOM   3828 C C   . VAL B 1 242 ? -70.712  73.366 43.775  1.00 32.87  ? 1092 VAL B C   1 
ATOM   3829 O O   . VAL B 1 242 ? -69.815  73.545 42.938  1.00 31.90  ? 1092 VAL B O   1 
ATOM   3830 C CB  . VAL B 1 242 ? -72.871  74.009 42.655  1.00 27.93  ? 1092 VAL B CB  1 
ATOM   3831 C CG1 . VAL B 1 242 ? -73.395  72.580 42.750  1.00 26.39  ? 1092 VAL B CG1 1 
ATOM   3832 C CG2 . VAL B 1 242 ? -74.018  75.007 42.640  1.00 28.43  ? 1092 VAL B CG2 1 
ATOM   3833 N N   . HIS B 1 243 ? -70.710  72.365 44.658  1.00 30.38  ? 1093 HIS B N   1 
ATOM   3834 C CA  . HIS B 1 243 ? -69.645  71.375 44.771  1.00 31.03  ? 1093 HIS B CA  1 
ATOM   3835 C C   . HIS B 1 243 ? -70.293  69.994 44.729  1.00 30.26  ? 1093 HIS B C   1 
ATOM   3836 O O   . HIS B 1 243 ? -71.088  69.658 45.612  1.00 31.05  ? 1093 HIS B O   1 
ATOM   3837 C CB  . HIS B 1 243 ? -68.869  71.612 46.076  1.00 31.87  ? 1093 HIS B CB  1 
ATOM   3838 C CG  . HIS B 1 243 ? -67.699  70.702 46.293  1.00 35.54  ? 1093 HIS B CG  1 
ATOM   3839 N ND1 . HIS B 1 243 ? -67.835  69.373 46.632  1.00 34.37  ? 1093 HIS B ND1 1 
ATOM   3840 C CD2 . HIS B 1 243 ? -66.367  70.950 46.273  1.00 35.18  ? 1093 HIS B CD2 1 
ATOM   3841 C CE1 . HIS B 1 243 ? -66.637  68.835 46.785  1.00 43.25  ? 1093 HIS B CE1 1 
ATOM   3842 N NE2 . HIS B 1 243 ? -65.729  69.771 46.572  1.00 37.40  ? 1093 HIS B NE2 1 
ATOM   3843 N N   . ILE B 1 244 ? -69.975  69.206 43.700  1.00 29.16  ? 1094 ILE B N   1 
ATOM   3844 C CA  . ILE B 1 244 ? -70.566  67.887 43.478  1.00 29.19  ? 1094 ILE B CA  1 
ATOM   3845 C C   . ILE B 1 244 ? -69.468  66.847 43.654  1.00 37.15  ? 1094 ILE B C   1 
ATOM   3846 O O   . ILE B 1 244 ? -68.452  66.886 42.952  1.00 32.04  ? 1094 ILE B O   1 
ATOM   3847 C CB  . ILE B 1 244 ? -71.191  67.773 42.079  1.00 28.04  ? 1094 ILE B CB  1 
ATOM   3848 C CG1 . ILE B 1 244 ? -72.339  68.769 41.907  1.00 27.05  ? 1094 ILE B CG1 1 
ATOM   3849 C CG2 . ILE B 1 244 ? -71.680  66.353 41.828  1.00 31.83  ? 1094 ILE B CG2 1 
ATOM   3850 C CD1 . ILE B 1 244 ? -72.873  68.824 40.492  1.00 28.61  ? 1094 ILE B CD1 1 
ATOM   3851 N N   . SER B 1 245 ? -69.680  65.903 44.569  1.00 30.11  ? 1095 SER B N   1 
ATOM   3852 C CA  . SER B 1 245 ? -68.687  64.904 44.932  1.00 28.84  ? 1095 SER B CA  1 
ATOM   3853 C C   . SER B 1 245 ? -69.279  63.510 44.790  1.00 38.05  ? 1095 SER B C   1 
ATOM   3854 O O   . SER B 1 245 ? -70.373  63.239 45.302  1.00 34.21  ? 1095 SER B O   1 
ATOM   3855 C CB  . SER B 1 245 ? -68.196  65.128 46.365  1.00 34.92  ? 1095 SER B CB  1 
ATOM   3856 O OG  . SER B 1 245 ? -67.347  64.076 46.786  1.00 40.84  ? 1095 SER B OG  1 
ATOM   3857 N N   . GLY B 1 246 ? -68.548  62.632 44.111  1.00 32.83  ? 1096 GLY B N   1 
ATOM   3858 C CA  . GLY B 1 246 ? -68.929  61.235 44.006  1.00 31.35  ? 1096 GLY B CA  1 
ATOM   3859 C C   . GLY B 1 246 ? -70.082  60.975 43.064  1.00 34.60  ? 1096 GLY B C   1 
ATOM   3860 O O   . GLY B 1 246 ? -70.908  60.093 43.330  1.00 34.37  ? 1096 GLY B O   1 
ATOM   3861 N N   . LEU B 1 247 ? -70.150  61.709 41.958  1.00 31.06  ? 1097 LEU B N   1 
ATOM   3862 C CA  . LEU B 1 247 ? -71.147  61.422 40.938  1.00 32.24  ? 1097 LEU B CA  1 
ATOM   3863 C C   . LEU B 1 247 ? -70.893  60.044 40.346  1.00 41.71  ? 1097 LEU B C   1 
ATOM   3864 O O   . LEU B 1 247 ? -69.774  59.731 39.929  1.00 36.92  ? 1097 LEU B O   1 
ATOM   3865 C CB  . LEU B 1 247 ? -71.098  62.486 39.844  1.00 37.24  ? 1097 LEU B CB  1 
ATOM   3866 C CG  . LEU B 1 247 ? -71.977  62.243 38.619  1.00 39.59  ? 1097 LEU B CG  1 
ATOM   3867 C CD1 . LEU B 1 247 ? -73.443  62.195 39.019  1.00 38.43  ? 1097 LEU B CD1 1 
ATOM   3868 C CD2 . LEU B 1 247 ? -71.726  63.316 37.574  1.00 39.82  ? 1097 LEU B CD2 1 
ATOM   3869 N N   . HIS B 1 248 ? -71.924  59.206 40.331  1.00 31.54  ? 1098 HIS B N   1 
ATOM   3870 C CA  . HIS B 1 248 ? -71.835  57.897 39.706  1.00 34.44  ? 1098 HIS B CA  1 
ATOM   3871 C C   . HIS B 1 248 ? -72.922  57.789 38.648  1.00 40.63  ? 1098 HIS B C   1 
ATOM   3872 O O   . HIS B 1 248 ? -74.093  58.078 38.920  1.00 35.35  ? 1098 HIS B O   1 
ATOM   3873 C CB  . HIS B 1 248 ? -71.961  56.783 40.750  1.00 37.02  ? 1098 HIS B CB  1 
ATOM   3874 C CG  . HIS B 1 248 ? -72.076  55.412 40.162  1.00 44.63  ? 1098 HIS B CG  1 
ATOM   3875 N ND1 . HIS B 1 248 ? -70.973  54.653 39.832  1.00 50.93  ? 1098 HIS B ND1 1 
ATOM   3876 C CD2 . HIS B 1 248 ? -73.157  54.656 39.859  1.00 45.83  ? 1098 HIS B CD2 1 
ATOM   3877 C CE1 . HIS B 1 248 ? -71.371  53.493 39.341  1.00 49.79  ? 1098 HIS B CE1 1 
ATOM   3878 N NE2 . HIS B 1 248 ? -72.691  53.469 39.349  1.00 50.87  ? 1098 HIS B NE2 1 
ATOM   3879 N N   . THR B 1 249 ? -72.524  57.351 37.460  1.00 32.87  ? 1099 THR B N   1 
ATOM   3880 C CA  . THR B 1 249 ? -73.460  57.217 36.327  1.00 33.64  ? 1099 THR B CA  1 
ATOM   3881 C C   . THR B 1 249 ? -73.456  55.773 35.838  1.00 41.54  ? 1099 THR B C   1 
ATOM   3882 O O   . THR B 1 249 ? -72.438  55.115 35.989  1.00 43.50  ? 1099 THR B O   1 
ATOM   3883 C CB  . THR B 1 249 ? -73.084  58.160 35.184  1.00 39.42  ? 1099 THR B CB  1 
ATOM   3884 O OG1 . THR B 1 249 ? -71.825  57.749 34.659  1.00 40.44  ? 1099 THR B OG1 1 
ATOM   3885 C CG2 . THR B 1 249 ? -73.020  59.605 35.621  1.00 36.22  ? 1099 THR B CG2 1 
ATOM   3886 N N   . GLU B 1 250 ? -74.560  55.333 35.271  1.00 35.93  ? 1100 GLU B N   1 
ATOM   3887 C CA  . GLU B 1 250 ? -74.682  53.968 34.719  1.00 40.47  ? 1100 GLU B CA  1 
ATOM   3888 C C   . GLU B 1 250 ? -75.292  54.069 33.322  1.00 47.60  ? 1100 GLU B C   1 
ATOM   3889 O O   . GLU B 1 250 ? -75.845  55.112 32.996  1.00 43.98  ? 1100 GLU B O   1 
ATOM   3890 C CB  . GLU B 1 250 ? -75.509  53.082 35.645  1.00 42.62  ? 1100 GLU B CB  1 
ATOM   3891 C CG  . GLU B 1 250 ? -74.884  52.903 37.012  1.00 48.53  ? 1100 GLU B CG  1 
ATOM   3892 C CD  . GLU B 1 250 ? -75.675  52.029 37.966  1.00 59.67  ? 1100 GLU B CD  1 
ATOM   3893 O OE1 . GLU B 1 250 ? -76.708  51.481 37.542  1.00 57.83  ? 1100 GLU B OE1 1 
ATOM   3894 O OE2 . GLU B 1 250 ? -75.269  51.918 39.135  1.00 58.90  ? 1100 GLU B OE2 1 
ATOM   3895 N N   . SER B 1 251 ? -75.211  52.995 32.556  1.00 49.00  ? 1101 SER B N   1 
ATOM   3896 C CA  . SER B 1 251 ? -75.652  53.037 31.146  1.00 55.30  ? 1101 SER B CA  1 
ATOM   3897 C C   . SER B 1 251 ? -77.161  52.933 31.009  1.00 62.79  ? 1101 SER B C   1 
ATOM   3898 O O   . SER B 1 251 ? -77.735  52.054 31.657  1.00 59.26  ? 1101 SER B O   1 
ATOM   3899 C CB  . SER B 1 251 ? -74.982  51.965 30.328  1.00 65.55  ? 1101 SER B CB  1 
ATOM   3900 O OG  . SER B 1 251 ? -75.294  50.682 30.843  1.00 73.14  ? 1101 SER B OG  1 
ATOM   3901 N N   . ALA B 1 252 ? -77.738  53.810 30.183  1.00 64.37  ? 1102 ALA B N   1 
ATOM   3902 C CA  . ALA B 1 252 ? -79.188  53.801 29.893  1.00 69.99  ? 1102 ALA B CA  1 
ATOM   3903 C C   . ALA B 1 252 ? -79.589  55.189 29.388  1.00 67.58  ? 1102 ALA B C   1 
ATOM   3904 O O   . ALA B 1 252 ? -80.760  55.553 29.565  1.00 72.62  ? 1102 ALA B O   1 
ATOM   3905 C CB  . ALA B 1 252 ? -79.990  53.404 31.103  1.00 72.08  ? 1102 ALA B CB  1 
ATOM   3906 N N   . SER C 1 1   ? -71.758  46.792 84.674  1.00 45.25  ? -7   SER C N   1 
ATOM   3907 C CA  . SER C 1 1   ? -70.949  46.747 83.458  1.00 45.39  ? -7   SER C CA  1 
ATOM   3908 C C   . SER C 1 1   ? -69.874  47.830 83.480  1.00 41.85  ? -7   SER C C   1 
ATOM   3909 O O   . SER C 1 1   ? -70.055  48.850 84.150  1.00 42.20  ? -7   SER C O   1 
ATOM   3910 C CB  . SER C 1 1   ? -71.831  46.903 82.214  1.00 49.16  ? -7   SER C CB  1 
ATOM   3911 O OG  . SER C 1 1   ? -72.674  48.039 82.312  1.00 46.72  ? -7   SER C OG  1 
ATOM   3912 N N   . GLU C 1 2   ? -68.734  47.597 82.812  1.00 43.36  ? -6   GLU C N   1 
ATOM   3913 C CA  . GLU C 1 2   ? -67.791  48.679 82.524  1.00 40.60  ? -6   GLU C CA  1 
ATOM   3914 C C   . GLU C 1 2   ? -68.211  49.292 81.211  1.00 36.67  ? -6   GLU C C   1 
ATOM   3915 O O   . GLU C 1 2   ? -68.264  48.604 80.186  1.00 35.53  ? -6   GLU C O   1 
ATOM   3916 C CB  . GLU C 1 2   ? -66.329  48.224 82.438  1.00 41.95  ? -6   GLU C CB  1 
ATOM   3917 C CG  . GLU C 1 2   ? -65.398  49.273 81.907  1.00 49.78  ? -6   GLU C CG  1 
ATOM   3918 C CD  . GLU C 1 2   ? -64.297  48.749 81.015  1.00 57.59  ? -6   GLU C CD  1 
ATOM   3919 O OE1 . GLU C 1 2   ? -64.512  47.779 80.260  1.00 55.80  ? -6   GLU C OE1 1 
ATOM   3920 O OE2 . GLU C 1 2   ? -63.200  49.346 81.060  1.00 56.67  ? -6   GLU C OE2 1 
ATOM   3921 N N   . ASN C 1 3   ? -68.485  50.584 81.245  1.00 33.84  ? -5   ASN C N   1 
ATOM   3922 C CA  . ASN C 1 3   ? -69.078  51.300 80.131  1.00 32.69  ? -5   ASN C CA  1 
ATOM   3923 C C   . ASN C 1 3   ? -68.064  52.287 79.573  1.00 31.38  ? -5   ASN C C   1 
ATOM   3924 O O   . ASN C 1 3   ? -67.402  53.001 80.334  1.00 35.69  ? -5   ASN C O   1 
ATOM   3925 C CB  . ASN C 1 3   ? -70.345  52.022 80.586  1.00 34.24  ? -5   ASN C CB  1 
ATOM   3926 C CG  . ASN C 1 3   ? -71.328  51.094 81.285  1.00 35.05  ? -5   ASN C CG  1 
ATOM   3927 O OD1 . ASN C 1 3   ? -71.245  49.870 81.166  1.00 34.49  ? -5   ASN C OD1 1 
ATOM   3928 N ND2 . ASN C 1 3   ? -72.250  51.677 82.041  1.00 38.63  ? -5   ASN C ND2 1 
ATOM   3929 N N   . LEU C 1 4   ? -67.939  52.315 78.250  1.00 30.16  ? -4   LEU C N   1 
ATOM   3930 C CA  . LEU C 1 4   ? -67.020  53.199 77.546  1.00 29.65  ? -4   LEU C CA  1 
ATOM   3931 C C   . LEU C 1 4   ? -67.831  54.088 76.613  1.00 29.33  ? -4   LEU C C   1 
ATOM   3932 O O   . LEU C 1 4   ? -68.638  53.581 75.830  1.00 28.79  ? -4   LEU C O   1 
ATOM   3933 C CB  . LEU C 1 4   ? -66.002  52.379 76.753  1.00 28.49  ? -4   LEU C CB  1 
ATOM   3934 C CG  . LEU C 1 4   ? -65.197  51.376 77.581  1.00 33.74  ? -4   LEU C CG  1 
ATOM   3935 C CD1 . LEU C 1 4   ? -64.364  50.476 76.682  1.00 35.27  ? -4   LEU C CD1 1 
ATOM   3936 C CD2 . LEU C 1 4   ? -64.315  52.107 78.574  1.00 39.19  ? -4   LEU C CD2 1 
ATOM   3937 N N   . TYR C 1 5   ? -67.626  55.403 76.685  1.00 28.83  ? -3   TYR C N   1 
ATOM   3938 C CA  . TYR C 1 5   ? -68.461  56.335 75.937  1.00 26.46  ? -3   TYR C CA  1 
ATOM   3939 C C   . TYR C 1 5   ? -67.669  57.064 74.860  1.00 30.00  ? -3   TYR C C   1 
ATOM   3940 O O   . TYR C 1 5   ? -66.480  57.355 75.022  1.00 31.30  ? -3   TYR C O   1 
ATOM   3941 C CB  . TYR C 1 5   ? -69.122  57.351 76.870  1.00 29.31  ? -3   TYR C CB  1 
ATOM   3942 C CG  . TYR C 1 5   ? -69.956  56.688 77.933  1.00 30.72  ? -3   TYR C CG  1 
ATOM   3943 C CD1 . TYR C 1 5   ? -71.183  56.117 77.622  1.00 32.34  ? -3   TYR C CD1 1 
ATOM   3944 C CD2 . TYR C 1 5   ? -69.513  56.620 79.245  1.00 33.77  ? -3   TYR C CD2 1 
ATOM   3945 C CE1 . TYR C 1 5   ? -71.947  55.499 78.592  1.00 34.35  ? -3   TYR C CE1 1 
ATOM   3946 C CE2 . TYR C 1 5   ? -70.270  56.007 80.222  1.00 34.32  ? -3   TYR C CE2 1 
ATOM   3947 C CZ  . TYR C 1 5   ? -71.486  55.448 79.891  1.00 36.46  ? -3   TYR C CZ  1 
ATOM   3948 O OH  . TYR C 1 5   ? -72.245  54.835 80.861  1.00 38.84  ? -3   TYR C OH  1 
ATOM   3949 N N   . PHE C 1 6   ? -68.353  57.374 73.759  1.00 28.64  ? -2   PHE C N   1 
ATOM   3950 C CA  . PHE C 1 6   ? -67.727  57.965 72.586  1.00 27.72  ? -2   PHE C CA  1 
ATOM   3951 C C   . PHE C 1 6   ? -68.563  59.129 72.081  1.00 30.65  ? -2   PHE C C   1 
ATOM   3952 O O   . PHE C 1 6   ? -69.779  59.000 71.908  1.00 29.83  ? -2   PHE C O   1 
ATOM   3953 C CB  . PHE C 1 6   ? -67.541  56.908 71.498  1.00 27.79  ? -2   PHE C CB  1 
ATOM   3954 C CG  . PHE C 1 6   ? -66.776  55.714 71.971  1.00 27.47  ? -2   PHE C CG  1 
ATOM   3955 C CD1 . PHE C 1 6   ? -65.392  55.709 71.941  1.00 25.74  ? -2   PHE C CD1 1 
ATOM   3956 C CD2 . PHE C 1 6   ? -67.436  54.619 72.505  1.00 25.95  ? -2   PHE C CD2 1 
ATOM   3957 C CE1 . PHE C 1 6   ? -64.680  54.619 72.398  1.00 27.38  ? -2   PHE C CE1 1 
ATOM   3958 C CE2 . PHE C 1 6   ? -66.731  53.527 72.968  1.00 29.13  ? -2   PHE C CE2 1 
ATOM   3959 C CZ  . PHE C 1 6   ? -65.350  53.526 72.914  1.00 30.21  ? -2   PHE C CZ  1 
ATOM   3960 N N   . GLN C 1 7   ? -67.900  60.259 71.830  1.00 28.46  ? -1   GLN C N   1 
ATOM   3961 C CA  . GLN C 1 7   ? -68.604  61.466 71.419  1.00 26.07  ? -1   GLN C CA  1 
ATOM   3962 C C   . GLN C 1 7   ? -69.102  61.395 69.979  1.00 28.37  ? -1   GLN C C   1 
ATOM   3963 O O   . GLN C 1 7   ? -69.996  62.164 69.613  1.00 29.70  ? -1   GLN C O   1 
ATOM   3964 C CB  . GLN C 1 7   ? -67.700  62.677 71.654  1.00 30.29  ? -1   GLN C CB  1 
ATOM   3965 C CG  . GLN C 1 7   ? -66.417  62.685 70.850  1.00 30.08  ? -1   GLN C CG  1 
ATOM   3966 C CD  . GLN C 1 7   ? -65.685  64.004 70.965  1.00 38.41  ? -1   GLN C CD  1 
ATOM   3967 O OE1 . GLN C 1 7   ? -66.115  65.014 70.409  1.00 37.55  ? -1   GLN C OE1 1 
ATOM   3968 N NE2 . GLN C 1 7   ? -64.578  64.008 71.702  1.00 33.03  ? -1   GLN C NE2 1 
ATOM   3969 N N   . SER C 1 8   ? -68.545  60.506 69.160  1.00 25.53  ? 858  SER C N   1 
ATOM   3970 C CA  . SER C 1 8   ? -69.021  60.284 67.798  1.00 25.90  ? 858  SER C CA  1 
ATOM   3971 C C   . SER C 1 8   ? -68.313  59.050 67.258  1.00 28.86  ? 858  SER C C   1 
ATOM   3972 O O   . SER C 1 8   ? -67.321  58.575 67.821  1.00 27.65  ? 858  SER C O   1 
ATOM   3973 C CB  . SER C 1 8   ? -68.816  61.485 66.868  1.00 30.75  ? 858  SER C CB  1 
ATOM   3974 O OG  . SER C 1 8   ? -67.449  61.780 66.678  1.00 31.47  ? 858  SER C OG  1 
ATOM   3975 N N   . ALA C 1 9   ? -68.852  58.527 66.163  1.00 26.28  ? 859  ALA C N   1 
ATOM   3976 C CA  . ALA C 1 9   ? -68.253  57.390 65.489  1.00 25.28  ? 859  ALA C CA  1 
ATOM   3977 C C   . ALA C 1 9   ? -68.605  57.452 64.013  1.00 25.93  ? 859  ALA C C   1 
ATOM   3978 O O   . ALA C 1 9   ? -69.484  58.207 63.591  1.00 26.03  ? 859  ALA C O   1 
ATOM   3979 C CB  . ALA C 1 9   ? -68.724  56.064 66.098  1.00 27.99  ? 859  ALA C CB  1 
ATOM   3980 N N   . ALA C 1 10  ? -67.876  56.670 63.227  1.00 24.83  ? 860  ALA C N   1 
ATOM   3981 C CA  . ALA C 1 10  ? -68.119  56.583 61.798  1.00 25.67  ? 860  ALA C CA  1 
ATOM   3982 C C   . ALA C 1 10  ? -67.628  55.233 61.309  1.00 28.17  ? 860  ALA C C   1 
ATOM   3983 O O   . ALA C 1 10  ? -66.656  54.688 61.829  1.00 29.03  ? 860  ALA C O   1 
ATOM   3984 C CB  . ALA C 1 10  ? -67.431  57.721 61.035  1.00 25.79  ? 860  ALA C CB  1 
ATOM   3985 N N   . ILE C 1 11  ? -68.306  54.687 60.308  1.00 23.89  ? 861  ILE C N   1 
ATOM   3986 C CA  . ILE C 1 11  ? -67.920  53.411 59.724  1.00 25.37  ? 861  ILE C CA  1 
ATOM   3987 C C   . ILE C 1 11  ? -67.614  53.633 58.251  1.00 27.78  ? 861  ILE C C   1 
ATOM   3988 O O   . ILE C 1 11  ? -68.401  54.259 57.532  1.00 29.65  ? 861  ILE C O   1 
ATOM   3989 C CB  . ILE C 1 11  ? -69.003  52.334 59.923  1.00 26.33  ? 861  ILE C CB  1 
ATOM   3990 C CG1 . ILE C 1 11  ? -69.042  51.899 61.391  1.00 28.15  ? 861  ILE C CG1 1 
ATOM   3991 C CG2 . ILE C 1 11  ? -68.735  51.138 59.030  1.00 29.00  ? 861  ILE C CG2 1 
ATOM   3992 C CD1 . ILE C 1 11  ? -70.225  51.018 61.756  1.00 30.62  ? 861  ILE C CD1 1 
ATOM   3993 N N   . TYR C 1 12  ? -66.461  53.136 57.818  1.00 26.29  ? 862  TYR C N   1 
ATOM   3994 C CA  . TYR C 1 12  ? -65.970  53.274 56.455  1.00 28.94  ? 862  TYR C CA  1 
ATOM   3995 C C   . TYR C 1 12  ? -66.001  51.892 55.821  1.00 28.71  ? 862  TYR C C   1 
ATOM   3996 O O   . TYR C 1 12  ? -65.252  50.995 56.230  1.00 30.12  ? 862  TYR C O   1 
ATOM   3997 C CB  . TYR C 1 12  ? -64.571  53.888 56.452  1.00 29.46  ? 862  TYR C CB  1 
ATOM   3998 C CG  . TYR C 1 12  ? -64.599  55.261 57.071  1.00 28.17  ? 862  TYR C CG  1 
ATOM   3999 C CD1 . TYR C 1 12  ? -64.493  55.431 58.447  1.00 27.37  ? 862  TYR C CD1 1 
ATOM   4000 C CD2 . TYR C 1 12  ? -64.809  56.383 56.287  1.00 27.98  ? 862  TYR C CD2 1 
ATOM   4001 C CE1 . TYR C 1 12  ? -64.557  56.687 59.015  1.00 23.99  ? 862  TYR C CE1 1 
ATOM   4002 C CE2 . TYR C 1 12  ? -64.874  57.639 56.843  1.00 26.76  ? 862  TYR C CE2 1 
ATOM   4003 C CZ  . TYR C 1 12  ? -64.748  57.788 58.206  1.00 25.23  ? 862  TYR C CZ  1 
ATOM   4004 O OH  . TYR C 1 12  ? -64.815  59.046 58.754  1.00 27.70  ? 862  TYR C OH  1 
ATOM   4005 N N   . ASN C 1 13  ? -66.915  51.709 54.874  1.00 31.04  ? 863  ASN C N   1 
ATOM   4006 C CA  . ASN C 1 13  ? -67.049  50.452 54.152  1.00 33.10  ? 863  ASN C CA  1 
ATOM   4007 C C   . ASN C 1 13  ? -66.208  50.568 52.886  1.00 39.61  ? 863  ASN C C   1 
ATOM   4008 O O   . ASN C 1 13  ? -66.559  51.305 51.959  1.00 44.08  ? 863  ASN C O   1 
ATOM   4009 C CB  . ASN C 1 13  ? -68.516  50.154 53.851  1.00 34.10  ? 863  ASN C CB  1 
ATOM   4010 C CG  . ASN C 1 13  ? -69.290  49.744 55.095  1.00 38.74  ? 863  ASN C CG  1 
ATOM   4011 O OD1 . ASN C 1 13  ? -68.766  49.045 55.960  1.00 38.69  ? 863  ASN C OD1 1 
ATOM   4012 N ND2 . ASN C 1 13  ? -70.540  50.182 55.192  1.00 45.66  ? 863  ASN C ND2 1 
ATOM   4013 N N   . ILE C 1 14  ? -65.097  49.836 52.856  1.00 35.25  ? 864  ILE C N   1 
ATOM   4014 C CA  . ILE C 1 14  ? -64.056  49.974 51.850  1.00 38.59  ? 864  ILE C CA  1 
ATOM   4015 C C   . ILE C 1 14  ? -64.251  48.863 50.832  1.00 40.03  ? 864  ILE C C   1 
ATOM   4016 O O   . ILE C 1 14  ? -64.289  47.680 51.202  1.00 41.90  ? 864  ILE C O   1 
ATOM   4017 C CB  . ILE C 1 14  ? -62.655  49.847 52.480  1.00 43.94  ? 864  ILE C CB  1 
ATOM   4018 C CG1 . ILE C 1 14  ? -62.364  50.923 53.531  1.00 44.35  ? 864  ILE C CG1 1 
ATOM   4019 C CG2 . ILE C 1 14  ? -61.594  49.921 51.396  1.00 46.43  ? 864  ILE C CG2 1 
ATOM   4020 C CD1 . ILE C 1 14  ? -62.681  52.306 53.126  1.00 44.01  ? 864  ILE C CD1 1 
ATOM   4021 N N   . ASP C 1 15  ? -64.322  49.235 49.553  1.00 39.98  ? 865  ASP C N   1 
ATOM   4022 C CA  . ASP C 1 15  ? -64.413  48.249 48.442  1.00 43.83  ? 865  ASP C CA  1 
ATOM   4023 C C   . ASP C 1 15  ? -63.241  48.464 47.481  1.00 43.82  ? 865  ASP C C   1 
ATOM   4024 O O   . ASP C 1 15  ? -63.027  49.601 47.088  1.00 42.17  ? 865  ASP C O   1 
ATOM   4025 C CB  . ASP C 1 15  ? -65.739  48.328 47.692  1.00 47.28  ? 865  ASP C CB  1 
ATOM   4026 C CG  . ASP C 1 15  ? -65.888  47.288 46.598  1.00 53.64  ? 865  ASP C CG  1 
ATOM   4027 O OD1 . ASP C 1 15  ? -64.986  46.450 46.454  1.00 55.90  ? 865  ASP C OD1 1 
ATOM   4028 O OD2 . ASP C 1 15  ? -66.905  47.335 45.898  1.00 67.13  ? 865  ASP C OD2 1 
ATOM   4029 N N   . THR C 1 16  ? -62.520  47.398 47.147  1.00 45.81  ? 866  THR C N   1 
ATOM   4030 C CA  . THR C 1 16  ? -61.315  47.503 46.283  1.00 44.00  ? 866  THR C CA  1 
ATOM   4031 C C   . THR C 1 16  ? -61.638  47.095 44.846  1.00 50.09  ? 866  THR C C   1 
ATOM   4032 O O   . THR C 1 16  ? -60.708  46.842 44.098  1.00 48.39  ? 866  THR C O   1 
ATOM   4033 C CB  . THR C 1 16  ? -60.179  46.665 46.861  1.00 45.95  ? 866  THR C CB  1 
ATOM   4034 O OG1 . THR C 1 16  ? -60.597  45.306 46.951  1.00 48.99  ? 866  THR C OG1 1 
ATOM   4035 C CG2 . THR C 1 16  ? -59.740  47.159 48.222  1.00 44.80  ? 866  THR C CG2 1 
ATOM   4036 N N   . SER C 1 17  ? -62.911  47.052 44.502  1.00 47.34  ? 867  SER C N   1 
ATOM   4037 C CA  . SER C 1 17  ? -63.354  46.717 43.130  1.00 52.61  ? 867  SER C CA  1 
ATOM   4038 C C   . SER C 1 17  ? -62.836  47.730 42.110  1.00 52.81  ? 867  SER C C   1 
ATOM   4039 O O   . SER C 1 17  ? -62.675  48.891 42.462  1.00 46.85  ? 867  SER C O   1 
ATOM   4040 C CB  . SER C 1 17  ? -64.858  46.630 43.066  1.00 46.33  ? 867  SER C CB  1 
ATOM   4041 O OG  . SER C 1 17  ? -65.428  47.921 43.063  1.00 60.15  ? 867  SER C OG  1 
ATOM   4042 N N   . SER C 1 18  ? -62.672  47.286 40.863  1.00 55.24  ? 868  SER C N   1 
ATOM   4043 C CA  . SER C 1 18  ? -62.113  48.123 39.777  1.00 52.05  ? 868  SER C CA  1 
ATOM   4044 C C   . SER C 1 18  ? -62.824  49.466 39.670  1.00 49.32  ? 868  SER C C   1 
ATOM   4045 O O   . SER C 1 18  ? -62.197  50.431 39.282  1.00 56.00  ? 868  SER C O   1 
ATOM   4046 C CB  . SER C 1 18  ? -62.196  47.370 38.480  1.00 58.53  ? 868  SER C CB  1 
ATOM   4047 O OG  . SER C 1 18  ? -63.536  47.308 38.026  1.00 69.97  ? 868  SER C OG  1 
ATOM   4048 N N   . GLU C 1 19  ? -64.094  49.499 40.003  1.00 56.55  ? 869  GLU C N   1 
ATOM   4049 C CA  . GLU C 1 19  ? -64.826  50.767 39.819  1.00 56.29  ? 869  GLU C CA  1 
ATOM   4050 C C   . GLU C 1 19  ? -64.734  51.646 41.073  1.00 57.56  ? 869  GLU C C   1 
ATOM   4051 O O   . GLU C 1 19  ? -64.981  52.851 40.948  1.00 57.89  ? 869  GLU C O   1 
ATOM   4052 C CB  . GLU C 1 19  ? -66.271  50.443 39.448  1.00 66.84  ? 869  GLU C CB  1 
ATOM   4053 C CG  . GLU C 1 19  ? -66.521  50.517 37.950  1.00 69.99  ? 869  GLU C CG  1 
ATOM   4054 C CD  . GLU C 1 19  ? -65.592  49.671 37.096  1.00 76.13  ? 869  GLU C CD  1 
ATOM   4055 O OE1 . GLU C 1 19  ? -65.645  48.435 37.223  1.00 79.73  ? 869  GLU C OE1 1 
ATOM   4056 O OE2 . GLU C 1 19  ? -64.808  50.249 36.316  1.00 70.99  ? 869  GLU C OE2 1 
ATOM   4057 N N   . SER C 1 20  ? -64.374  51.075 42.222  1.00 51.03  ? 870  SER C N   1 
ATOM   4058 C CA  . SER C 1 20  ? -64.385  51.854 43.481  1.00 44.11  ? 870  SER C CA  1 
ATOM   4059 C C   . SER C 1 20  ? -63.318  52.933 43.493  1.00 44.21  ? 870  SER C C   1 
ATOM   4060 O O   . SER C 1 20  ? -62.243  52.718 42.957  1.00 46.37  ? 870  SER C O   1 
ATOM   4061 C CB  . SER C 1 20  ? -64.224  50.973 44.689  1.00 48.33  ? 870  SER C CB  1 
ATOM   4062 O OG  . SER C 1 20  ? -64.131  51.737 45.876  1.00 46.98  ? 870  SER C OG  1 
ATOM   4063 N N   . PRO C 1 21  ? -63.590  54.059 44.157  1.00 43.66  ? 871  PRO C N   1 
ATOM   4064 C CA  . PRO C 1 21  ? -62.585  55.076 44.322  1.00 43.73  ? 871  PRO C CA  1 
ATOM   4065 C C   . PRO C 1 21  ? -61.445  54.524 45.192  1.00 43.58  ? 871  PRO C C   1 
ATOM   4066 O O   . PRO C 1 21  ? -60.451  55.178 45.283  1.00 44.57  ? 871  PRO C O   1 
ATOM   4067 C CB  . PRO C 1 21  ? -63.328  56.146 45.106  1.00 47.84  ? 871  PRO C CB  1 
ATOM   4068 C CG  . PRO C 1 21  ? -64.785  55.876 44.871  1.00 50.07  ? 871  PRO C CG  1 
ATOM   4069 C CD  . PRO C 1 21  ? -64.865  54.374 44.785  1.00 48.11  ? 871  PRO C CD  1 
ATOM   4070 N N   . ASP C 1 22  ? -61.638  53.353 45.797  1.00 37.53  ? 872  ASP C N   1 
ATOM   4071 C CA  . ASP C 1 22  ? -60.620  52.752 46.695  1.00 38.42  ? 872  ASP C CA  1 
ATOM   4072 C C   . ASP C 1 22  ? -59.952  51.554 46.008  1.00 40.07  ? 872  ASP C C   1 
ATOM   4073 O O   . ASP C 1 22  ? -59.282  50.780 46.684  1.00 35.25  ? 872  ASP C O   1 
ATOM   4074 C CB  . ASP C 1 22  ? -61.231  52.443 48.057  1.00 42.52  ? 872  ASP C CB  1 
ATOM   4075 C CG  . ASP C 1 22  ? -61.806  53.675 48.730  1.00 42.12  ? 872  ASP C CG  1 
ATOM   4076 O OD1 . ASP C 1 22  ? -61.086  54.680 48.828  1.00 42.25  ? 872  ASP C OD1 1 
ATOM   4077 O OD2 . ASP C 1 22  ? -62.959  53.609 49.158  1.00 42.55  ? 872  ASP C OD2 1 
ATOM   4078 N N   . HIS C 1 23  ? -60.125  51.446 44.688  1.00 37.38  ? 873  HIS C N   1 
ATOM   4079 C CA  . HIS C 1 23  ? -59.446  50.373 43.970  1.00 40.74  ? 873  HIS C CA  1 
ATOM   4080 C C   . HIS C 1 23  ? -57.933  50.443 44.142  1.00 34.11  ? 873  HIS C C   1 
ATOM   4081 O O   . HIS C 1 23  ? -57.269  49.400 44.192  1.00 38.14  ? 873  HIS C O   1 
ATOM   4082 C CB  . HIS C 1 23  ? -59.798  50.422 42.483  1.00 42.86  ? 873  HIS C CB  1 
ATOM   4083 C CG  . HIS C 1 23  ? -59.122  49.359 41.675  1.00 39.23  ? 873  HIS C CG  1 
ATOM   4084 N ND1 . HIS C 1 23  ? -59.379  48.017 41.849  1.00 42.16  ? 873  HIS C ND1 1 
ATOM   4085 C CD2 . HIS C 1 23  ? -58.171  49.439 40.714  1.00 44.35  ? 873  HIS C CD2 1 
ATOM   4086 C CE1 . HIS C 1 23  ? -58.630  47.316 41.016  1.00 46.21  ? 873  HIS C CE1 1 
ATOM   4087 N NE2 . HIS C 1 23  ? -57.887  48.155 40.317  1.00 44.95  ? 873  HIS C NE2 1 
ATOM   4088 N N   . TYR C 1 24  ? -57.376  51.655 44.256  1.00 34.91  ? 874  TYR C N   1 
ATOM   4089 C CA  . TYR C 1 24  ? -55.928  51.838 44.358  1.00 35.25  ? 874  TYR C CA  1 
ATOM   4090 C C   . TYR C 1 24  ? -55.311  51.006 45.476  1.00 38.08  ? 874  TYR C C   1 
ATOM   4091 O O   . TYR C 1 24  ? -54.126  50.642 45.401  1.00 36.24  ? 874  TYR C O   1 
ATOM   4092 C CB  . TYR C 1 24  ? -55.608  53.324 44.568  1.00 33.33  ? 874  TYR C CB  1 
ATOM   4093 C CG  . TYR C 1 24  ? -55.882  53.835 45.968  1.00 37.64  ? 874  TYR C CG  1 
ATOM   4094 C CD1 . TYR C 1 24  ? -57.156  54.238 46.350  1.00 38.28  ? 874  TYR C CD1 1 
ATOM   4095 C CD2 . TYR C 1 24  ? -54.861  53.923 46.905  1.00 34.67  ? 874  TYR C CD2 1 
ATOM   4096 C CE1 . TYR C 1 24  ? -57.405  54.707 47.631  1.00 36.10  ? 874  TYR C CE1 1 
ATOM   4097 C CE2 . TYR C 1 24  ? -55.099  54.388 48.184  1.00 33.50  ? 874  TYR C CE2 1 
ATOM   4098 C CZ  . TYR C 1 24  ? -56.371  54.779 48.543  1.00 35.09  ? 874  TYR C CZ  1 
ATOM   4099 O OH  . TYR C 1 24  ? -56.607  55.244 49.817  1.00 31.83  ? 874  TYR C OH  1 
ATOM   4100 N N   . LEU C 1 25  ? -56.103  50.662 46.492  1.00 34.18  ? 875  LEU C N   1 
ATOM   4101 C CA  . LEU C 1 25  ? -55.591  49.900 47.619  1.00 36.70  ? 875  LEU C CA  1 
ATOM   4102 C C   . LEU C 1 25  ? -55.076  48.527 47.211  1.00 36.07  ? 875  LEU C C   1 
ATOM   4103 O O   . LEU C 1 25  ? -54.238  47.963 47.922  1.00 36.75  ? 875  LEU C O   1 
ATOM   4104 C CB  . LEU C 1 25  ? -56.686  49.755 48.677  1.00 31.84  ? 875  LEU C CB  1 
ATOM   4105 C CG  . LEU C 1 25  ? -57.017  51.060 49.402  1.00 32.91  ? 875  LEU C CG  1 
ATOM   4106 C CD1 . LEU C 1 25  ? -58.223  50.911 50.317  1.00 32.90  ? 875  LEU C CD1 1 
ATOM   4107 C CD2 . LEU C 1 25  ? -55.803  51.524 50.189  1.00 35.36  ? 875  LEU C CD2 1 
ATOM   4108 N N   . VAL C 1 26  ? -55.518  47.990 46.069  1.00 36.02  ? 876  VAL C N   1 
ATOM   4109 C CA  . VAL C 1 26  ? -55.040  46.672 45.663  1.00 35.60  ? 876  VAL C CA  1 
ATOM   4110 C C   . VAL C 1 26  ? -53.551  46.670 45.367  1.00 39.71  ? 876  VAL C C   1 
ATOM   4111 O O   . VAL C 1 26  ? -52.946  45.594 45.291  1.00 42.15  ? 876  VAL C O   1 
ATOM   4112 C CB  . VAL C 1 26  ? -55.787  46.132 44.424  1.00 43.98  ? 876  VAL C CB  1 
ATOM   4113 C CG1 . VAL C 1 26  ? -57.294  46.089 44.668  1.00 39.72  ? 876  VAL C CG1 1 
ATOM   4114 C CG2 . VAL C 1 26  ? -55.434  46.927 43.173  1.00 41.10  ? 876  VAL C CG2 1 
ATOM   4115 N N   . ASP C 1 27  ? -52.943  47.848 45.214  1.00 37.73  ? 877  ASP C N   1 
ATOM   4116 C CA  . ASP C 1 27  ? -51.525  47.941 44.896  1.00 39.72  ? 877  ASP C CA  1 
ATOM   4117 C C   . ASP C 1 27  ? -50.637  48.061 46.125  1.00 43.53  ? 877  ASP C C   1 
ATOM   4118 O O   . ASP C 1 27  ? -49.444  48.352 45.988  1.00 40.79  ? 877  ASP C O   1 
ATOM   4119 C CB  . ASP C 1 27  ? -51.288  49.120 43.959  1.00 36.53  ? 877  ASP C CB  1 
ATOM   4120 C CG  . ASP C 1 27  ? -51.621  48.784 42.526  1.00 40.53  ? 877  ASP C CG  1 
ATOM   4121 O OD1 . ASP C 1 27  ? -51.807  47.585 42.226  1.00 41.03  ? 877  ASP C OD1 1 
ATOM   4122 O OD2 . ASP C 1 27  ? -51.722  49.717 41.706  1.00 40.43  ? 877  ASP C OD2 1 
ATOM   4123 N N   . HIS C 1 28  ? -51.200  47.836 47.320  1.00 38.86  ? 878  HIS C N   1 
ATOM   4124 C CA  . HIS C 1 28  ? -50.420  47.856 48.591  1.00 36.86  ? 878  HIS C CA  1 
ATOM   4125 C C   . HIS C 1 28  ? -50.407  46.432 49.130  1.00 41.75  ? 878  HIS C C   1 
ATOM   4126 O O   . HIS C 1 28  ? -51.165  46.102 50.031  1.00 47.07  ? 878  HIS C O   1 
ATOM   4127 C CB  . HIS C 1 28  ? -50.960  48.879 49.588  1.00 37.81  ? 878  HIS C CB  1 
ATOM   4128 C CG  . HIS C 1 28  ? -50.181  49.019 50.844  1.00 36.95  ? 878  HIS C CG  1 
ATOM   4129 N ND1 . HIS C 1 28  ? -50.337  48.181 51.922  1.00 37.76  ? 878  HIS C ND1 1 
ATOM   4130 C CD2 . HIS C 1 28  ? -49.288  49.934 51.211  1.00 37.72  ? 878  HIS C CD2 1 
ATOM   4131 C CE1 . HIS C 1 28  ? -49.533  48.574 52.891  1.00 42.44  ? 878  HIS C CE1 1 
ATOM   4132 N NE2 . HIS C 1 28  ? -48.884  49.635 52.479  1.00 40.35  ? 878  HIS C NE2 1 
ATOM   4133 N N   . THR C 1 29  ? -49.584  45.602 48.518  1.00 46.54  ? 879  THR C N   1 
ATOM   4134 C CA  . THR C 1 29  ? -49.466  44.182 48.896  1.00 53.17  ? 879  THR C CA  1 
ATOM   4135 C C   . THR C 1 29  ? -48.121  44.032 49.599  1.00 57.06  ? 879  THR C C   1 
ATOM   4136 O O   . THR C 1 29  ? -47.100  44.298 48.978  1.00 59.46  ? 879  THR C O   1 
ATOM   4137 C CB  . THR C 1 29  ? -49.509  43.299 47.644  1.00 49.44  ? 879  THR C CB  1 
ATOM   4138 O OG1 . THR C 1 29  ? -50.762  43.468 46.984  1.00 52.93  ? 879  THR C OG1 1 
ATOM   4139 C CG2 . THR C 1 29  ? -49.277  41.838 47.954  1.00 60.23  ? 879  THR C CG2 1 
ATOM   4140 N N   . LEU C 1 30  ? -48.133  43.672 50.862  1.00 58.57  ? 880  LEU C N   1 
ATOM   4141 C CA  . LEU C 1 30  ? -46.874  43.530 51.625  1.00 66.20  ? 880  LEU C CA  1 
ATOM   4142 C C   . LEU C 1 30  ? -46.713  42.038 51.837  1.00 70.54  ? 880  LEU C C   1 
ATOM   4143 O O   . LEU C 1 30  ? -47.657  41.405 52.347  1.00 69.23  ? 880  LEU C O   1 
ATOM   4144 C CB  . LEU C 1 30  ? -46.916  44.352 52.914  1.00 64.70  ? 880  LEU C CB  1 
ATOM   4145 C CG  . LEU C 1 30  ? -46.821  45.861 52.712  1.00 59.53  ? 880  LEU C CG  1 
ATOM   4146 C CD1 . LEU C 1 30  ? -46.198  46.529 53.923  1.00 60.04  ? 880  LEU C CD1 1 
ATOM   4147 C CD2 . LEU C 1 30  ? -46.020  46.181 51.465  1.00 55.45  ? 880  LEU C CD2 1 
ATOM   4148 N N   . ASP C 1 31  ? -45.554  41.518 51.449  1.00 70.28  ? 881  ASP C N   1 
ATOM   4149 C CA  . ASP C 1 31  ? -45.407  40.052 51.401  1.00 74.79  ? 881  ASP C CA  1 
ATOM   4150 C C   . ASP C 1 31  ? -46.244  39.657 50.187  1.00 72.46  ? 881  ASP C C   1 
ATOM   4151 O O   . ASP C 1 31  ? -45.924  40.131 49.087  1.00 73.57  ? 881  ASP C O   1 
ATOM   4152 C CB  . ASP C 1 31  ? -45.810  39.349 52.690  1.00 76.82  ? 881  ASP C CB  1 
ATOM   4153 C CG  . ASP C 1 31  ? -44.621  38.779 53.445  1.00 82.18  ? 881  ASP C CG  1 
ATOM   4154 O OD1 . ASP C 1 31  ? -43.477  39.095 53.062  1.00 80.36  ? 881  ASP C OD1 1 
ATOM   4155 O OD2 . ASP C 1 31  ? -44.847  38.039 54.419  1.00 80.09  ? 881  ASP C OD2 1 
ATOM   4156 N N   . GLY C 1 32  ? -47.264  38.846 50.387  1.00 66.44  ? 882  GLY C N   1 
ATOM   4157 C CA  . GLY C 1 32  ? -48.131  38.432 49.278  1.00 64.09  ? 882  GLY C CA  1 
ATOM   4158 C C   . GLY C 1 32  ? -49.567  38.637 49.674  1.00 70.44  ? 882  GLY C C   1 
ATOM   4159 O O   . GLY C 1 32  ? -50.420  37.896 49.164  1.00 66.22  ? 882  GLY C O   1 
ATOM   4160 N N   . ARG C 1 33  ? -49.792  39.603 50.575  1.00 60.31  ? 883  ARG C N   1 
ATOM   4161 C CA  . ARG C 1 33  ? -51.172  39.892 51.036  1.00 65.08  ? 883  ARG C CA  1 
ATOM   4162 C C   . ARG C 1 33  ? -51.533  41.362 50.785  1.00 59.28  ? 883  ARG C C   1 
ATOM   4163 O O   . ARG C 1 33  ? -50.619  42.199 50.875  1.00 57.73  ? 883  ARG C O   1 
ATOM   4164 C CB  . ARG C 1 33  ? -51.282  39.516 52.517  1.00 68.27  ? 883  ARG C CB  1 
ATOM   4165 C CG  . ARG C 1 33  ? -50.903  38.075 52.827  1.00 72.97  ? 883  ARG C CG  1 
ATOM   4166 C CD  . ARG C 1 33  ? -51.176  37.620 54.249  1.00 79.35  ? 883  ARG C CD  1 
ATOM   4167 N NE  . ARG C 1 33  ? -52.556  37.212 54.477  1.00 86.96  ? 883  ARG C NE  1 
ATOM   4168 C CZ  . ARG C 1 33  ? -52.940  35.996 54.853  1.00 84.22  ? 883  ARG C CZ  1 
ATOM   4169 N NH1 . ARG C 1 33  ? -52.106  34.976 54.763  1.00 84.98  ? 883  ARG C NH1 1 
ATOM   4170 N NH2 . ARG C 1 33  ? -54.165  35.800 55.309  1.00 78.80  ? 883  ARG C NH2 1 
ATOM   4171 N N   . VAL C 1 34  ? -52.788  41.643 50.428  1.00 55.69  ? 884  VAL C N   1 
ATOM   4172 C CA  . VAL C 1 34  ? -53.266  43.053 50.310  1.00 53.35  ? 884  VAL C CA  1 
ATOM   4173 C C   . VAL C 1 34  ? -53.506  43.599 51.718  1.00 44.61  ? 884  VAL C C   1 
ATOM   4174 O O   . VAL C 1 34  ? -54.470  43.203 52.365  1.00 41.64  ? 884  VAL C O   1 
ATOM   4175 C CB  . VAL C 1 34  ? -54.526  43.189 49.452  1.00 46.18  ? 884  VAL C CB  1 
ATOM   4176 C CG1 . VAL C 1 34  ? -55.070  44.605 49.485  1.00 51.30  ? 884  VAL C CG1 1 
ATOM   4177 C CG2 . VAL C 1 34  ? -54.257  42.754 48.023  1.00 55.57  ? 884  VAL C CG2 1 
ATOM   4178 N N   . LEU C 1 35  ? -52.635  44.486 52.143  1.00 42.78  ? 885  LEU C N   1 
ATOM   4179 C CA  . LEU C 1 35  ? -52.709  45.023 53.507  1.00 43.66  ? 885  LEU C CA  1 
ATOM   4180 C C   . LEU C 1 35  ? -53.255  46.442 53.460  1.00 40.03  ? 885  LEU C C   1 
ATOM   4181 O O   . LEU C 1 35  ? -52.755  47.233 52.683  1.00 37.19  ? 885  LEU C O   1 
ATOM   4182 C CB  . LEU C 1 35  ? -51.290  45.011 54.073  1.00 43.80  ? 885  LEU C CB  1 
ATOM   4183 C CG  . LEU C 1 35  ? -51.149  45.082 55.586  1.00 46.44  ? 885  LEU C CG  1 
ATOM   4184 C CD1 . LEU C 1 35  ? -51.704  43.824 56.212  1.00 55.10  ? 885  LEU C CD1 1 
ATOM   4185 C CD2 . LEU C 1 35  ? -49.686  45.237 55.954  1.00 59.39  ? 885  LEU C CD2 1 
ATOM   4186 N N   . PHE C 1 36  ? -54.277  46.714 54.243  1.00 36.40  ? 886  PHE C N   1 
ATOM   4187 C CA  . PHE C 1 36  ? -54.755  48.077 54.389  1.00 28.75  ? 886  PHE C CA  1 
ATOM   4188 C C   . PHE C 1 36  ? -53.624  48.901 54.994  1.00 33.37  ? 886  PHE C C   1 
ATOM   4189 O O   . PHE C 1 36  ? -53.059  48.505 56.023  1.00 33.19  ? 886  PHE C O   1 
ATOM   4190 C CB  . PHE C 1 36  ? -56.001  48.151 55.270  1.00 32.19  ? 886  PHE C CB  1 
ATOM   4191 C CG  . PHE C 1 36  ? -56.744  49.457 55.158  1.00 33.10  ? 886  PHE C CG  1 
ATOM   4192 C CD1 . PHE C 1 36  ? -57.603  49.701 54.098  1.00 33.74  ? 886  PHE C CD1 1 
ATOM   4193 C CD2 . PHE C 1 36  ? -56.572  50.445 56.113  1.00 29.26  ? 886  PHE C CD2 1 
ATOM   4194 C CE1 . PHE C 1 36  ? -58.282  50.906 54.000  1.00 32.16  ? 886  PHE C CE1 1 
ATOM   4195 C CE2 . PHE C 1 36  ? -57.246  51.649 56.020  1.00 31.29  ? 886  PHE C CE2 1 
ATOM   4196 C CZ  . PHE C 1 36  ? -58.101  51.880 54.962  1.00 32.55  ? 886  PHE C CZ  1 
ATOM   4197 N N   . PRO C 1 37  ? -53.229  50.004 54.371  1.00 33.71  ? 887  PRO C N   1 
ATOM   4198 C CA  . PRO C 1 37  ? -52.058  50.743 54.853  1.00 31.65  ? 887  PRO C CA  1 
ATOM   4199 C C   . PRO C 1 37  ? -52.351  51.539 56.117  1.00 32.91  ? 887  PRO C C   1 
ATOM   4200 O O   . PRO C 1 37  ? -53.456  52.042 56.325  1.00 30.67  ? 887  PRO C O   1 
ATOM   4201 C CB  . PRO C 1 37  ? -51.717  51.670 53.679  1.00 29.73  ? 887  PRO C CB  1 
ATOM   4202 C CG  . PRO C 1 37  ? -52.983  51.801 52.902  1.00 33.42  ? 887  PRO C CG  1 
ATOM   4203 C CD  . PRO C 1 37  ? -53.783  50.555 53.123  1.00 32.54  ? 887  PRO C CD  1 
ATOM   4204 N N   . ALA C 1 38  ? -51.325  51.636 56.972  1.00 35.60  ? 888  ALA C N   1 
ATOM   4205 C CA  . ALA C 1 38  ? -51.405  52.475 58.169  1.00 29.58  ? 888  ALA C CA  1 
ATOM   4206 C C   . ALA C 1 38  ? -51.866  53.896 57.838  1.00 29.27  ? 888  ALA C C   1 
ATOM   4207 O O   . ALA C 1 38  ? -52.663  54.508 58.576  1.00 30.26  ? 888  ALA C O   1 
ATOM   4208 C CB  . ALA C 1 38  ? -50.043  52.496 58.868  1.00 30.95  ? 888  ALA C CB  1 
ATOM   4209 N N   . THR C 1 39  ? -51.388  54.435 56.715  1.00 28.15  ? 889  THR C N   1 
ATOM   4210 C CA  . THR C 1 39  ? -51.803  55.775 56.331  1.00 27.98  ? 889  THR C CA  1 
ATOM   4211 C C   . THR C 1 39  ? -53.277  55.804 55.936  1.00 27.55  ? 889  THR C C   1 
ATOM   4212 O O   . THR C 1 39  ? -53.919  56.860 56.026  1.00 29.60  ? 889  THR C O   1 
ATOM   4213 C CB  . THR C 1 39  ? -50.915  56.290 55.193  1.00 29.64  ? 889  THR C CB  1 
ATOM   4214 O OG1 . THR C 1 39  ? -51.048  55.437 54.051  1.00 30.78  ? 889  THR C OG1 1 
ATOM   4215 C CG2 . THR C 1 39  ? -49.451  56.289 55.629  1.00 30.66  ? 889  THR C CG2 1 
ATOM   4216 N N   . GLY C 1 40  ? -53.847  54.650 55.579  1.00 27.83  ? 890  GLY C N   1 
ATOM   4217 C CA  . GLY C 1 40  ? -55.285  54.583 55.374  1.00 27.39  ? 890  GLY C CA  1 
ATOM   4218 C C   . GLY C 1 40  ? -56.069  54.792 56.659  1.00 28.89  ? 890  GLY C C   1 
ATOM   4219 O O   . GLY C 1 40  ? -57.125  55.448 56.661  1.00 28.34  ? 890  GLY C O   1 
ATOM   4220 N N   . TYR C 1 41  ? -55.557  54.263 57.777  1.00 28.78  ? 891  TYR C N   1 
ATOM   4221 C CA  . TYR C 1 41  ? -56.184  54.549 59.063  1.00 25.54  ? 891  TYR C CA  1 
ATOM   4222 C C   . TYR C 1 41  ? -56.097  56.029 59.381  1.00 27.36  ? 891  TYR C C   1 
ATOM   4223 O O   . TYR C 1 41  ? -57.066  56.624 59.876  1.00 26.15  ? 891  TYR C O   1 
ATOM   4224 C CB  . TYR C 1 41  ? -55.531  53.753 60.193  1.00 26.79  ? 891  TYR C CB  1 
ATOM   4225 C CG  . TYR C 1 41  ? -55.489  52.265 59.989  1.00 27.22  ? 891  TYR C CG  1 
ATOM   4226 C CD1 . TYR C 1 41  ? -56.649  51.538 59.758  1.00 28.65  ? 891  TYR C CD1 1 
ATOM   4227 C CD2 . TYR C 1 41  ? -54.285  51.582 60.045  1.00 31.91  ? 891  TYR C CD2 1 
ATOM   4228 C CE1 . TYR C 1 41  ? -56.604  50.169 59.575  1.00 31.73  ? 891  TYR C CE1 1 
ATOM   4229 C CE2 . TYR C 1 41  ? -54.229  50.222 59.865  1.00 31.84  ? 891  TYR C CE2 1 
ATOM   4230 C CZ  . TYR C 1 41  ? -55.388  49.519 59.630  1.00 32.84  ? 891  TYR C CZ  1 
ATOM   4231 O OH  . TYR C 1 41  ? -55.323  48.159 59.452  1.00 33.40  ? 891  TYR C OH  1 
ATOM   4232 N N   . LEU C 1 42  ? -54.930  56.637 59.127  1.00 25.49  ? 892  LEU C N   1 
ATOM   4233 C CA  . LEU C 1 42  ? -54.821  58.080 59.343  1.00 28.16  ? 892  LEU C CA  1 
ATOM   4234 C C   . LEU C 1 42  ? -55.902  58.827 58.575  1.00 28.02  ? 892  LEU C C   1 
ATOM   4235 O O   . LEU C 1 42  ? -56.529  59.757 59.101  1.00 27.58  ? 892  LEU C O   1 
ATOM   4236 C CB  . LEU C 1 42  ? -53.447  58.587 58.911  1.00 26.59  ? 892  LEU C CB  1 
ATOM   4237 C CG  . LEU C 1 42  ? -52.230  57.995 59.612  1.00 30.36  ? 892  LEU C CG  1 
ATOM   4238 C CD1 . LEU C 1 42  ? -50.971  58.710 59.148  1.00 30.77  ? 892  LEU C CD1 1 
ATOM   4239 C CD2 . LEU C 1 42  ? -52.380  58.065 61.124  1.00 30.36  ? 892  LEU C CD2 1 
ATOM   4240 N N   . SER C 1 43  ? -56.136  58.417 57.327  1.00 26.47  ? 893  SER C N   1 
ATOM   4241 C CA  . SER C 1 43  ? -57.132  59.085 56.494  1.00 27.97  ? 893  SER C CA  1 
ATOM   4242 C C   . SER C 1 43  ? -58.527  58.996 57.106  1.00 27.20  ? 893  SER C C   1 
ATOM   4243 O O   . SER C 1 43  ? -59.232  60.009 57.220  1.00 27.67  ? 893  SER C O   1 
ATOM   4244 C CB  . SER C 1 43  ? -57.123  58.478 55.093  1.00 28.63  ? 893  SER C CB  1 
ATOM   4245 O OG  . SER C 1 43  ? -58.116  59.060 54.268  1.00 33.06  ? 893  SER C OG  1 
ATOM   4246 N N   . ILE C 1 44  ? -58.952  57.791 57.505  1.00 27.93  ? 894  ILE C N   1 
ATOM   4247 C CA  . ILE C 1 44  ? -60.336  57.695 57.985  1.00 27.04  ? 894  ILE C CA  1 
ATOM   4248 C C   . ILE C 1 44  ? -60.504  58.356 59.358  1.00 26.74  ? 894  ILE C C   1 
ATOM   4249 O O   . ILE C 1 44  ? -61.568  58.924 59.653  1.00 25.83  ? 894  ILE C O   1 
ATOM   4250 C CB  . ILE C 1 44  ? -60.845  56.238 57.979  1.00 26.15  ? 894  ILE C CB  1 
ATOM   4251 C CG1 . ILE C 1 44  ? -60.038  55.346 58.924  1.00 26.71  ? 894  ILE C CG1 1 
ATOM   4252 C CG2 . ILE C 1 44  ? -60.893  55.687 56.550  1.00 26.52  ? 894  ILE C CG2 1 
ATOM   4253 C CD1 . ILE C 1 44  ? -60.545  53.911 58.977  1.00 29.05  ? 894  ILE C CD1 1 
ATOM   4254 N N   . VAL C 1 45  ? -59.462  58.356 60.195  1.00 25.90  ? 895  VAL C N   1 
ATOM   4255 C CA  . VAL C 1 45  ? -59.552  59.086 61.461  1.00 25.32  ? 895  VAL C CA  1 
ATOM   4256 C C   . VAL C 1 45  ? -59.664  60.587 61.204  1.00 27.92  ? 895  VAL C C   1 
ATOM   4257 O O   . VAL C 1 45  ? -60.458  61.293 61.848  1.00 27.87  ? 895  VAL C O   1 
ATOM   4258 C CB  . VAL C 1 45  ? -58.345  58.752 62.356  1.00 27.02  ? 895  VAL C CB  1 
ATOM   4259 C CG1 . VAL C 1 45  ? -58.348  59.613 63.615  1.00 24.93  ? 895  VAL C CG1 1 
ATOM   4260 C CG2 . VAL C 1 45  ? -58.346  57.277 62.712  1.00 26.49  ? 895  VAL C CG2 1 
ATOM   4261 N N   . TRP C 1 46  ? -58.849  61.097 60.279  1.00 24.68  ? 896  TRP C N   1 
ATOM   4262 C CA  . TRP C 1 46  ? -58.917  62.497 59.877  1.00 24.54  ? 896  TRP C CA  1 
ATOM   4263 C C   . TRP C 1 46  ? -60.317  62.865 59.404  1.00 24.77  ? 896  TRP C C   1 
ATOM   4264 O O   . TRP C 1 46  ? -60.865  63.907 59.784  1.00 27.19  ? 896  TRP C O   1 
ATOM   4265 C CB  . TRP C 1 46  ? -57.893  62.717 58.768  1.00 27.19  ? 896  TRP C CB  1 
ATOM   4266 C CG  . TRP C 1 46  ? -57.558  64.114 58.401  1.00 28.20  ? 896  TRP C CG  1 
ATOM   4267 C CD1 . TRP C 1 46  ? -57.950  65.266 59.019  1.00 29.86  ? 896  TRP C CD1 1 
ATOM   4268 C CD2 . TRP C 1 46  ? -56.737  64.502 57.303  1.00 30.71  ? 896  TRP C CD2 1 
ATOM   4269 N NE1 . TRP C 1 46  ? -57.415  66.353 58.363  1.00 31.38  ? 896  TRP C NE1 1 
ATOM   4270 C CE2 . TRP C 1 46  ? -56.666  65.906 57.304  1.00 30.12  ? 896  TRP C CE2 1 
ATOM   4271 C CE3 . TRP C 1 46  ? -56.051  63.791 56.313  1.00 29.53  ? 896  TRP C CE3 1 
ATOM   4272 C CZ2 . TRP C 1 46  ? -55.936  66.614 56.353  1.00 31.70  ? 896  TRP C CZ2 1 
ATOM   4273 C CZ3 . TRP C 1 46  ? -55.331  64.491 55.373  1.00 31.71  ? 896  TRP C CZ3 1 
ATOM   4274 C CH2 . TRP C 1 46  ? -55.277  65.888 55.397  1.00 28.60  ? 896  TRP C CH2 1 
ATOM   4275 N N   . LYS C 1 47  ? -60.914  62.005 58.575  1.00 27.28  ? 897  LYS C N   1 
ATOM   4276 C CA  . LYS C 1 47  ? -62.262  62.260 58.074  1.00 25.65  ? 897  LYS C CA  1 
ATOM   4277 C C   . LYS C 1 47  ? -63.289  62.255 59.202  1.00 25.74  ? 897  LYS C C   1 
ATOM   4278 O O   . LYS C 1 47  ? -64.269  63.011 59.160  1.00 26.15  ? 897  LYS C O   1 
ATOM   4279 C CB  . LYS C 1 47  ? -62.613  61.219 57.010  1.00 26.53  ? 897  LYS C CB  1 
ATOM   4280 C CG  . LYS C 1 47  ? -61.838  61.383 55.701  1.00 28.85  ? 897  LYS C CG  1 
ATOM   4281 C CD  . LYS C 1 47  ? -62.240  60.317 54.692  1.00 28.62  ? 897  LYS C CD  1 
ATOM   4282 C CE  . LYS C 1 47  ? -61.536  60.488 53.355  1.00 35.23  ? 897  LYS C CE  1 
ATOM   4283 N NZ  . LYS C 1 47  ? -61.907  59.379 52.431  1.00 34.08  ? 897  LYS C NZ  1 
ATOM   4284 N N   . THR C 1 48  ? -63.071  61.430 60.230  1.00 25.61  ? 898  THR C N   1 
ATOM   4285 C CA  . THR C 1 48  ? -64.009  61.377 61.350  1.00 26.81  ? 898  THR C CA  1 
ATOM   4286 C C   . THR C 1 48  ? -63.938  62.648 62.197  1.00 27.93  ? 898  THR C C   1 
ATOM   4287 O O   . THR C 1 48  ? -64.975  63.207 62.603  1.00 25.73  ? 898  THR C O   1 
ATOM   4288 C CB  . THR C 1 48  ? -63.710  60.138 62.191  1.00 24.56  ? 898  THR C CB  1 
ATOM   4289 O OG1 . THR C 1 48  ? -63.755  58.980 61.347  1.00 25.07  ? 898  THR C OG1 1 
ATOM   4290 C CG2 . THR C 1 48  ? -64.732  59.981 63.303  1.00 24.15  ? 898  THR C CG2 1 
ATOM   4291 N N   . LEU C 1 49  ? -62.721  63.130 62.459  1.00 25.66  ? 899  LEU C N   1 
ATOM   4292 C CA  . LEU C 1 49  ? -62.578  64.419 63.132  1.00 27.16  ? 899  LEU C CA  1 
ATOM   4293 C C   . LEU C 1 49  ? -63.207  65.536 62.304  1.00 24.20  ? 899  LEU C C   1 
ATOM   4294 O O   . LEU C 1 49  ? -63.909  66.406 62.843  1.00 28.52  ? 899  LEU C O   1 
ATOM   4295 C CB  . LEU C 1 49  ? -61.102  64.713 63.406  1.00 24.09  ? 899  LEU C CB  1 
ATOM   4296 C CG  . LEU C 1 49  ? -60.811  66.072 64.047  1.00 28.98  ? 899  LEU C CG  1 
ATOM   4297 C CD1 . LEU C 1 49  ? -61.449  66.150 65.424  1.00 32.00  ? 899  LEU C CD1 1 
ATOM   4298 C CD2 . LEU C 1 49  ? -59.313  66.336 64.133  1.00 31.28  ? 899  LEU C CD2 1 
ATOM   4299 N N   . ALA C 1 50  ? -62.980  65.514 60.986  1.00 27.94  ? 900  ALA C N   1 
ATOM   4300 C CA  . ALA C 1 50  ? -63.572  66.521 60.111  1.00 27.80  ? 900  ALA C CA  1 
ATOM   4301 C C   . ALA C 1 50  ? -65.089  66.524 60.222  1.00 29.93  ? 900  ALA C C   1 
ATOM   4302 O O   . ALA C 1 50  ? -65.709  67.591 60.308  1.00 29.75  ? 900  ALA C O   1 
ATOM   4303 C CB  . ALA C 1 50  ? -63.140  66.278 58.665  1.00 30.74  ? 900  ALA C CB  1 
ATOM   4304 N N   . ARG C 1 51  ? -65.701  65.337 60.246  1.00 30.71  ? 901  ARG C N   1 
ATOM   4305 C CA  . ARG C 1 51  ? -67.149  65.259 60.413  1.00 30.54  ? 901  ARG C CA  1 
ATOM   4306 C C   . ARG C 1 51  ? -67.583  65.903 61.720  1.00 33.55  ? 901  ARG C C   1 
ATOM   4307 O O   . ARG C 1 51  ? -68.559  66.664 61.753  1.00 31.19  ? 901  ARG C O   1 
ATOM   4308 C CB  . ARG C 1 51  ? -67.611  63.804 60.380  1.00 31.47  ? 901  ARG C CB  1 
ATOM   4309 C CG  . ARG C 1 51  ? -69.119  63.645 60.266  1.00 30.80  ? 901  ARG C CG  1 
ATOM   4310 C CD  . ARG C 1 51  ? -69.575  63.994 58.863  1.00 31.18  ? 901  ARG C CD  1 
ATOM   4311 N NE  . ARG C 1 51  ? -71.012  63.840 58.675  1.00 31.08  ? 901  ARG C NE  1 
ATOM   4312 C CZ  . ARG C 1 51  ? -71.637  64.074 57.529  1.00 36.59  ? 901  ARG C CZ  1 
ATOM   4313 N NH1 . ARG C 1 51  ? -70.977  64.471 56.453  1.00 28.50  ? 901  ARG C NH1 1 
ATOM   4314 N NH2 . ARG C 1 51  ? -72.957  63.923 57.466  1.00 33.31  ? 901  ARG C NH2 1 
ATOM   4315 N N   . ALA C 1 52  ? -66.863  65.616 62.808  1.00 27.34  ? 902  ALA C N   1 
ATOM   4316 C CA  . ALA C 1 52  ? -67.247  66.190 64.095  1.00 28.10  ? 902  ALA C CA  1 
ATOM   4317 C C   . ALA C 1 52  ? -67.122  67.712 64.106  1.00 34.69  ? 902  ALA C C   1 
ATOM   4318 O O   . ALA C 1 52  ? -67.850  68.387 64.844  1.00 36.14  ? 902  ALA C O   1 
ATOM   4319 C CB  . ALA C 1 52  ? -66.409  65.576 65.216  1.00 34.27  ? 902  ALA C CB  1 
ATOM   4320 N N   . LEU C 1 53  ? -66.207  68.265 63.305  1.00 33.97  ? 903  LEU C N   1 
ATOM   4321 C CA  . LEU C 1 53  ? -65.965  69.706 63.258  1.00 33.51  ? 903  LEU C CA  1 
ATOM   4322 C C   . LEU C 1 53  ? -66.720  70.425 62.141  1.00 39.83  ? 903  LEU C C   1 
ATOM   4323 O O   . LEU C 1 53  ? -66.610  71.652 62.032  1.00 39.23  ? 903  LEU C O   1 
ATOM   4324 C CB  . LEU C 1 53  ? -64.466  69.976 63.102  1.00 31.85  ? 903  LEU C CB  1 
ATOM   4325 C CG  . LEU C 1 53  ? -63.539  69.513 64.228  1.00 35.16  ? 903  LEU C CG  1 
ATOM   4326 C CD1 . LEU C 1 53  ? -62.084  69.759 63.847  1.00 30.47  ? 903  LEU C CD1 1 
ATOM   4327 C CD2 . LEU C 1 53  ? -63.878  70.190 65.551  1.00 34.77  ? 903  LEU C CD2 1 
ATOM   4328 N N   . GLY C 1 54  ? -67.458  69.704 61.300  1.00 34.86  ? 904  GLY C N   1 
ATOM   4329 C CA  . GLY C 1 54  ? -68.149  70.331 60.185  1.00 35.40  ? 904  GLY C CA  1 
ATOM   4330 C C   . GLY C 1 54  ? -67.246  70.867 59.095  1.00 45.48  ? 904  GLY C C   1 
ATOM   4331 O O   . GLY C 1 54  ? -67.602  71.843 58.426  1.00 45.40  ? 904  GLY C O   1 
ATOM   4332 N N   . LEU C 1 55  ? -66.089  70.242 58.888  1.00 40.88  ? 905  LEU C N   1 
ATOM   4333 C CA  . LEU C 1 55  ? -65.084  70.688 57.937  1.00 34.09  ? 905  LEU C CA  1 
ATOM   4334 C C   . LEU C 1 55  ? -64.811  69.594 56.912  1.00 36.43  ? 905  LEU C C   1 
ATOM   4335 O O   . LEU C 1 55  ? -65.134  68.423 57.125  1.00 36.42  ? 905  LEU C O   1 
ATOM   4336 C CB  . LEU C 1 55  ? -63.775  71.036 58.654  1.00 35.10  ? 905  LEU C CB  1 
ATOM   4337 C CG  . LEU C 1 55  ? -63.754  72.306 59.498  1.00 40.72  ? 905  LEU C CG  1 
ATOM   4338 C CD1 . LEU C 1 55  ? -62.522  72.304 60.386  1.00 41.98  ? 905  LEU C CD1 1 
ATOM   4339 C CD2 . LEU C 1 55  ? -63.779  73.531 58.603  1.00 43.71  ? 905  LEU C CD2 1 
ATOM   4340 N N   . GLY C 1 56  ? -64.232  69.994 55.783  1.00 37.08  ? 906  GLY C N   1 
ATOM   4341 C CA  . GLY C 1 56  ? -63.570  69.059 54.896  1.00 37.36  ? 906  GLY C CA  1 
ATOM   4342 C C   . GLY C 1 56  ? -62.126  68.874 55.315  1.00 33.90  ? 906  GLY C C   1 
ATOM   4343 O O   . GLY C 1 56  ? -61.532  69.747 55.946  1.00 35.88  ? 906  GLY C O   1 
ATOM   4344 N N   . VAL C 1 57  ? -61.542  67.737 54.946  1.00 36.92  ? 907  VAL C N   1 
ATOM   4345 C CA  . VAL C 1 57  ? -60.145  67.513 55.360  1.00 37.77  ? 907  VAL C CA  1 
ATOM   4346 C C   . VAL C 1 57  ? -59.134  68.547 54.920  1.00 40.30  ? 907  VAL C C   1 
ATOM   4347 O O   . VAL C 1 57  ? -58.095  68.745 55.560  1.00 38.39  ? 907  VAL C O   1 
ATOM   4348 C CB  . VAL C 1 57  ? -59.746  66.031 55.018  1.00 37.75  ? 907  VAL C CB  1 
ATOM   4349 C CG1 . VAL C 1 57  ? -60.468  64.972 55.927  1.00 31.08  ? 907  VAL C CG1 1 
ATOM   4350 C CG2 . VAL C 1 57  ? -59.885  65.707 53.568  1.00 41.82  ? 907  VAL C CG2 1 
ATOM   4351 N N   . GLU C 1 58  ? -59.318  69.017 53.679  1.00 37.95  ? 908  GLU C N   1 
ATOM   4352 C CA  A GLU C 1 58  ? -58.363  69.983 53.073  0.46 38.38  ? 908  GLU C CA  1 
ATOM   4353 C CA  B GLU C 1 58  ? -58.365  69.990 53.072  0.54 38.35  ? 908  GLU C CA  1 
ATOM   4354 C C   . GLU C 1 58  ? -58.289  71.290 53.871  1.00 36.56  ? 908  GLU C C   1 
ATOM   4355 O O   . GLU C 1 58  ? -57.331  72.080 53.900  1.00 42.41  ? 908  GLU C O   1 
ATOM   4356 C CB  A GLU C 1 58  ? -58.835  70.335 51.674  0.46 42.56  ? 908  GLU C CB  1 
ATOM   4357 C CB  B GLU C 1 58  ? -58.810  70.294 51.645  0.54 42.56  ? 908  GLU C CB  1 
ATOM   4358 C CG  A GLU C 1 58  ? -58.772  69.182 50.697  0.46 41.90  ? 908  GLU C CG  1 
ATOM   4359 C CG  B GLU C 1 58  ? -58.010  71.402 50.986  0.54 42.77  ? 908  GLU C CG  1 
ATOM   4360 C CD  A GLU C 1 58  ? -57.374  68.642 50.463  0.46 43.50  ? 908  GLU C CD  1 
ATOM   4361 C CD  B GLU C 1 58  ? -56.611  71.009 50.544  0.54 44.20  ? 908  GLU C CD  1 
ATOM   4362 O OE1 A GLU C 1 58  ? -56.459  69.463 50.248  0.46 45.84  ? 908  GLU C OE1 1 
ATOM   4363 O OE1 B GLU C 1 58  ? -56.280  69.812 50.627  0.54 44.68  ? 908  GLU C OE1 1 
ATOM   4364 O OE2 A GLU C 1 58  ? -57.205  67.411 50.528  0.46 45.08  ? 908  GLU C OE2 1 
ATOM   4365 O OE2 B GLU C 1 58  ? -55.866  71.899 50.099  0.54 45.08  ? 908  GLU C OE2 1 
ATOM   4366 N N   . GLN C 1 59  ? -59.355  71.509 54.607  1.00 36.80  ? 909  GLN C N   1 
ATOM   4367 C CA  . GLN C 1 59  ? -59.437  72.624 55.452  1.00 33.63  ? 909  GLN C CA  1 
ATOM   4368 C C   . GLN C 1 59  ? -59.126  72.324 56.927  1.00 39.44  ? 909  GLN C C   1 
ATOM   4369 O O   . GLN C 1 59  ? -59.309  73.205 57.794  1.00 38.86  ? 909  GLN C O   1 
ATOM   4370 C CB  . GLN C 1 59  ? -60.819  73.310 55.390  1.00 42.72  ? 909  GLN C CB  1 
ATOM   4371 C CG  . GLN C 1 59  ? -61.093  74.137 54.125  1.00 40.09  ? 909  GLN C CG  1 
ATOM   4372 C CD  . GLN C 1 59  ? -61.451  73.241 52.935  1.00 43.70  ? 909  GLN C CD  1 
ATOM   4373 O OE1 . GLN C 1 59  ? -62.373  72.420 53.019  1.00 44.78  ? 909  GLN C OE1 1 
ATOM   4374 N NE2 . GLN C 1 59  ? -60.751  73.413 51.824  1.00 44.48  ? 909  GLN C NE2 1 
ATOM   4375 N N   . LEU C 1 60  ? -58.610  71.141 57.228  1.00 35.74  ? 910  LEU C N   1 
ATOM   4376 C CA  . LEU C 1 60  ? -58.405  70.672 58.595  1.00 33.32  ? 910  LEU C CA  1 
ATOM   4377 C C   . LEU C 1 60  ? -56.947  70.276 58.779  1.00 32.32  ? 910  LEU C C   1 
ATOM   4378 O O   . LEU C 1 60  ? -56.592  69.096 58.622  1.00 29.20  ? 910  LEU C O   1 
ATOM   4379 C CB  . LEU C 1 60  ? -59.327  69.495 58.904  1.00 32.31  ? 910  LEU C CB  1 
ATOM   4380 C CG  . LEU C 1 60  ? -59.242  68.882 60.304  1.00 33.56  ? 910  LEU C CG  1 
ATOM   4381 C CD1 . LEU C 1 60  ? -59.238  69.956 61.382  1.00 30.22  ? 910  LEU C CD1 1 
ATOM   4382 C CD2 . LEU C 1 60  ? -60.360  67.883 60.526  1.00 28.89  ? 910  LEU C CD2 1 
ATOM   4383 N N   . PRO C 1 61  ? -56.066  71.217 59.113  1.00 32.85  ? 911  PRO C N   1 
ATOM   4384 C CA  . PRO C 1 61  ? -54.739  70.821 59.597  1.00 33.08  ? 911  PRO C CA  1 
ATOM   4385 C C   . PRO C 1 61  ? -54.897  70.009 60.870  1.00 29.91  ? 911  PRO C C   1 
ATOM   4386 O O   . PRO C 1 61  ? -55.737  70.314 61.720  1.00 33.87  ? 911  PRO C O   1 
ATOM   4387 C CB  . PRO C 1 61  ? -54.021  72.151 59.850  1.00 37.54  ? 911  PRO C CB  1 
ATOM   4388 C CG  . PRO C 1 61  ? -55.060  73.203 59.806  1.00 41.16  ? 911  PRO C CG  1 
ATOM   4389 C CD  . PRO C 1 61  ? -56.252  72.677 59.078  1.00 37.79  ? 911  PRO C CD  1 
ATOM   4390 N N   . VAL C 1 62  ? -54.106  68.948 60.987  1.00 31.60  ? 912  VAL C N   1 
ATOM   4391 C CA  . VAL C 1 62  ? -54.394  67.922 61.979  1.00 29.04  ? 912  VAL C CA  1 
ATOM   4392 C C   . VAL C 1 62  ? -53.100  67.403 62.590  1.00 31.75  ? 912  VAL C C   1 
ATOM   4393 O O   . VAL C 1 62  ? -52.051  67.346 61.935  1.00 29.14  ? 912  VAL C O   1 
ATOM   4394 C CB  . VAL C 1 62  ? -55.225  66.778 61.347  1.00 29.52  ? 912  VAL C CB  1 
ATOM   4395 C CG1 . VAL C 1 62  ? -54.444  66.085 60.237  1.00 30.09  ? 912  VAL C CG1 1 
ATOM   4396 C CG2 . VAL C 1 62  ? -55.692  65.788 62.397  1.00 29.19  ? 912  VAL C CG2 1 
ATOM   4397 N N   . VAL C 1 63  ? -53.185  67.033 63.870  1.00 30.77  ? 913  VAL C N   1 
ATOM   4398 C CA  . VAL C 1 63  ? -52.098  66.382 64.590  1.00 28.54  ? 913  VAL C CA  1 
ATOM   4399 C C   . VAL C 1 63  ? -52.587  65.020 65.056  1.00 29.63  ? 913  VAL C C   1 
ATOM   4400 O O   . VAL C 1 63  ? -53.671  64.908 65.643  1.00 30.29  ? 913  VAL C O   1 
ATOM   4401 C CB  . VAL C 1 63  ? -51.619  67.205 65.801  1.00 31.83  ? 913  VAL C CB  1 
ATOM   4402 C CG1 . VAL C 1 63  ? -50.341  66.599 66.381  1.00 33.89  ? 913  VAL C CG1 1 
ATOM   4403 C CG2 . VAL C 1 63  ? -51.415  68.662 65.432  1.00 32.87  ? 913  VAL C CG2 1 
ATOM   4404 N N   . PHE C 1 64  ? -51.780  63.996 64.802  1.00 27.04  ? 914  PHE C N   1 
ATOM   4405 C CA  . PHE C 1 64  ? -51.917  62.683 65.408  1.00 28.28  ? 914  PHE C CA  1 
ATOM   4406 C C   . PHE C 1 64  ? -50.809  62.531 66.438  1.00 36.09  ? 914  PHE C C   1 
ATOM   4407 O O   . PHE C 1 64  ? -49.663  62.909 66.178  1.00 33.08  ? 914  PHE C O   1 
ATOM   4408 C CB  . PHE C 1 64  ? -51.796  61.565 64.365  1.00 27.97  ? 914  PHE C CB  1 
ATOM   4409 C CG  . PHE C 1 64  ? -52.884  61.570 63.332  1.00 33.60  ? 914  PHE C CG  1 
ATOM   4410 C CD1 . PHE C 1 64  ? -52.802  62.396 62.223  1.00 30.44  ? 914  PHE C CD1 1 
ATOM   4411 C CD2 . PHE C 1 64  ? -53.988  60.747 63.468  1.00 32.09  ? 914  PHE C CD2 1 
ATOM   4412 C CE1 . PHE C 1 64  ? -53.801  62.400 61.270  1.00 33.10  ? 914  PHE C CE1 1 
ATOM   4413 C CE2 . PHE C 1 64  ? -54.990  60.747 62.519  1.00 31.33  ? 914  PHE C CE2 1 
ATOM   4414 C CZ  . PHE C 1 64  ? -54.897  61.575 61.419  1.00 29.88  ? 914  PHE C CZ  1 
ATOM   4415 N N   . GLU C 1 65  ? -51.138  61.961 67.592  1.00 30.00  ? 915  GLU C N   1 
ATOM   4416 C CA  . GLU C 1 65  ? -50.143  61.725 68.628  1.00 31.08  ? 915  GLU C CA  1 
ATOM   4417 C C   . GLU C 1 65  ? -50.290  60.315 69.176  1.00 34.82  ? 915  GLU C C   1 
ATOM   4418 O O   . GLU C 1 65  ? -51.407  59.806 69.324  1.00 29.90  ? 915  GLU C O   1 
ATOM   4419 C CB  . GLU C 1 65  ? -50.267  62.739 69.783  1.00 34.97  ? 915  GLU C CB  1 
ATOM   4420 C CG  . GLU C 1 65  ? -49.798  64.146 69.442  1.00 36.70  ? 915  GLU C CG  1 
ATOM   4421 C CD  . GLU C 1 65  ? -49.919  65.113 70.609  1.00 43.56  ? 915  GLU C CD  1 
ATOM   4422 O OE1 . GLU C 1 65  ? -50.461  64.723 71.665  1.00 44.25  ? 915  GLU C OE1 1 
ATOM   4423 O OE2 . GLU C 1 65  ? -49.472  66.271 70.465  1.00 42.58  ? 915  GLU C OE2 1 
ATOM   4424 N N   . ASP C 1 66  ? -49.148  59.700 69.486  1.00 30.62  ? 916  ASP C N   1 
ATOM   4425 C CA  . ASP C 1 66  ? -49.096  58.393 70.136  1.00 32.16  ? 916  ASP C CA  1 
ATOM   4426 C C   . ASP C 1 66  ? -49.936  57.360 69.385  1.00 33.66  ? 916  ASP C C   1 
ATOM   4427 O O   . ASP C 1 66  ? -50.712  56.601 69.972  1.00 27.63  ? 916  ASP C O   1 
ATOM   4428 C CB  . ASP C 1 66  ? -49.515  58.501 71.603  1.00 36.93  ? 916  ASP C CB  1 
ATOM   4429 C CG  . ASP C 1 66  ? -48.702  59.536 72.362  1.00 42.22  ? 916  ASP C CG  1 
ATOM   4430 O OD1 . ASP C 1 66  ? -47.490  59.660 72.086  1.00 40.95  ? 916  ASP C OD1 1 
ATOM   4431 O OD2 . ASP C 1 66  ? -49.274  60.233 73.226  1.00 43.76  ? 916  ASP C OD2 1 
ATOM   4432 N N   . VAL C 1 67  ? -49.777  57.338 68.061  1.00 31.40  ? 917  VAL C N   1 
ATOM   4433 C CA  . VAL C 1 67  ? -50.499  56.370 67.247  1.00 30.08  ? 917  VAL C CA  1 
ATOM   4434 C C   . VAL C 1 67  ? -49.925  54.989 67.515  1.00 31.53  ? 917  VAL C C   1 
ATOM   4435 O O   . VAL C 1 67  ? -48.706  54.783 67.461  1.00 30.56  ? 917  VAL C O   1 
ATOM   4436 C CB  . VAL C 1 67  ? -50.410  56.734 65.758  1.00 27.15  ? 917  VAL C CB  1 
ATOM   4437 C CG1 . VAL C 1 67  ? -51.058  55.649 64.901  1.00 29.25  ? 917  VAL C CG1 1 
ATOM   4438 C CG2 . VAL C 1 67  ? -51.067  58.079 65.506  1.00 27.50  ? 917  VAL C CG2 1 
ATOM   4439 N N   . VAL C 1 68  ? -50.803  54.033 67.796  1.00 28.76  ? 918  VAL C N   1 
ATOM   4440 C CA  . VAL C 1 68  ? -50.410  52.666 68.100  1.00 29.51  ? 918  VAL C CA  1 
ATOM   4441 C C   . VAL C 1 68  ? -51.184  51.744 67.170  1.00 31.46  ? 918  VAL C C   1 
ATOM   4442 O O   . VAL C 1 68  ? -52.420  51.783 67.140  1.00 28.71  ? 918  VAL C O   1 
ATOM   4443 C CB  . VAL C 1 68  ? -50.678  52.323 69.574  1.00 30.23  ? 918  VAL C CB  1 
ATOM   4444 C CG1 . VAL C 1 68  ? -50.342  50.891 69.851  1.00 29.19  ? 918  VAL C CG1 1 
ATOM   4445 C CG2 . VAL C 1 68  ? -49.863  53.239 70.482  1.00 32.33  ? 918  VAL C CG2 1 
ATOM   4446 N N   . LEU C 1 69  ? -50.462  50.922 66.411  1.00 29.21  ? 919  LEU C N   1 
ATOM   4447 C CA  . LEU C 1 69  ? -51.070  49.997 65.461  1.00 27.10  ? 919  LEU C CA  1 
ATOM   4448 C C   . LEU C 1 69  ? -51.061  48.589 66.046  1.00 31.70  ? 919  LEU C C   1 
ATOM   4449 O O   . LEU C 1 69  ? -50.004  47.958 66.156  1.00 30.42  ? 919  LEU C O   1 
ATOM   4450 C CB  . LEU C 1 69  ? -50.330  50.068 64.130  1.00 30.23  ? 919  LEU C CB  1 
ATOM   4451 C CG  . LEU C 1 69  ? -50.443  51.502 63.596  1.00 36.11  ? 919  LEU C CG  1 
ATOM   4452 C CD1 . LEU C 1 69  ? -49.074  52.155 63.385  1.00 37.13  ? 919  LEU C CD1 1 
ATOM   4453 C CD2 . LEU C 1 69  ? -51.309  51.580 62.345  1.00 37.07  ? 919  LEU C CD2 1 
ATOM   4454 N N   . HIS C 1 70  ? -52.250  48.078 66.364  1.00 28.91  ? 920  HIS C N   1 
ATOM   4455 C CA  . HIS C 1 70  ? -52.367  46.837 67.120  1.00 28.93  ? 920  HIS C CA  1 
ATOM   4456 C C   . HIS C 1 70  ? -52.420  45.596 66.249  1.00 32.01  ? 920  HIS C C   1 
ATOM   4457 O O   . HIS C 1 70  ? -52.034  44.515 66.708  1.00 32.16  ? 920  HIS C O   1 
ATOM   4458 C CB  . HIS C 1 70  ? -53.610  46.887 68.009  1.00 27.41  ? 920  HIS C CB  1 
ATOM   4459 C CG  . HIS C 1 70  ? -53.608  48.032 68.969  1.00 28.20  ? 920  HIS C CG  1 
ATOM   4460 N ND1 . HIS C 1 70  ? -53.094  47.925 70.243  1.00 27.03  ? 920  HIS C ND1 1 
ATOM   4461 C CD2 . HIS C 1 70  ? -54.033  49.311 68.840  1.00 28.46  ? 920  HIS C CD2 1 
ATOM   4462 C CE1 . HIS C 1 70  ? -53.213  49.086 70.862  1.00 31.58  ? 920  HIS C CE1 1 
ATOM   4463 N NE2 . HIS C 1 70  ? -53.779  49.944 70.033  1.00 31.90  ? 920  HIS C NE2 1 
ATOM   4464 N N   . GLN C 1 71  ? -52.924  45.726 65.040  1.00 29.58  ? 921  GLN C N   1 
ATOM   4465 C CA  A GLN C 1 71  ? -52.885  44.559 64.126  0.50 31.96  ? 921  GLN C CA  1 
ATOM   4466 C CA  B GLN C 1 71  ? -53.085  44.588 64.110  0.50 32.11  ? 921  GLN C CA  1 
ATOM   4467 C C   . GLN C 1 71  ? -53.068  45.055 62.642  1.00 33.75  ? 921  GLN C C   1 
ATOM   4468 O O   . GLN C 1 71  ? -53.241  46.252 62.324  1.00 37.44  ? 921  GLN C O   1 
ATOM   4469 C CB  A GLN C 1 71  ? -54.035  43.600 64.479  0.50 37.12  ? 921  GLN C CB  1 
ATOM   4470 C CB  B GLN C 1 71  ? -54.454  43.935 64.332  0.50 36.20  ? 921  GLN C CB  1 
ATOM   4471 C CG  A GLN C 1 71  ? -55.440  44.178 64.394  0.50 33.99  ? 921  GLN C CG  1 
ATOM   4472 C CG  B GLN C 1 71  ? -54.849  43.741 65.788  0.50 36.21  ? 921  GLN C CG  1 
ATOM   4473 C CD  A GLN C 1 71  ? -56.498  43.102 64.194  0.50 38.76  ? 921  GLN C CD  1 
ATOM   4474 C CD  B GLN C 1 71  ? -54.269  42.488 66.396  0.50 35.27  ? 921  GLN C CD  1 
ATOM   4475 O OE1 A GLN C 1 71  ? -57.297  43.164 63.265  0.50 42.27  ? 921  GLN C OE1 1 
ATOM   4476 O OE1 B GLN C 1 71  ? -53.567  41.722 65.742  0.50 37.38  ? 921  GLN C OE1 1 
ATOM   4477 N NE2 A GLN C 1 71  ? -56.511  42.114 65.082  0.50 44.54  ? 921  GLN C NE2 1 
ATOM   4478 N NE2 B GLN C 1 71  ? -54.564  42.268 67.666  0.50 36.35  ? 921  GLN C NE2 1 
ATOM   4479 N N   . ALA C 1 72  ? -52.619  44.169 61.773  1.00 36.59  ? 922  ALA C N   1 
ATOM   4480 C CA  . ALA C 1 72  ? -52.744  44.455 60.358  1.00 43.75  ? 922  ALA C CA  1 
ATOM   4481 C C   . ALA C 1 72  ? -54.119  44.018 59.872  1.00 43.22  ? 922  ALA C C   1 
ATOM   4482 O O   . ALA C 1 72  ? -54.707  43.067 60.393  1.00 46.92  ? 922  ALA C O   1 
ATOM   4483 C CB  . ALA C 1 72  ? -51.644  43.745 59.570  1.00 41.68  ? 922  ALA C CB  1 
ATOM   4484 N N   . THR C 1 73  ? -54.625  44.746 58.886  1.00 37.04  ? 923  THR C N   1 
ATOM   4485 C CA  . THR C 1 73  ? -55.941  44.418 58.294  1.00 37.98  ? 923  THR C CA  1 
ATOM   4486 C C   . THR C 1 73  ? -55.723  43.924 56.867  1.00 39.09  ? 923  THR C C   1 
ATOM   4487 O O   . THR C 1 73  ? -55.272  44.699 56.046  1.00 38.24  ? 923  THR C O   1 
ATOM   4488 C CB  . THR C 1 73  ? -56.908  45.607 58.353  1.00 38.56  ? 923  THR C CB  1 
ATOM   4489 O OG1 . THR C 1 73  ? -57.028  46.032 59.709  1.00 38.39  ? 923  THR C OG1 1 
ATOM   4490 C CG2 . THR C 1 73  ? -58.268  45.285 57.777  1.00 39.05  ? 923  THR C CG2 1 
ATOM   4491 N N   . ILE C 1 74  ? -56.035  42.668 56.630  1.00 45.99  ? 924  ILE C N   1 
ATOM   4492 C CA  . ILE C 1 74  ? -55.918  42.076 55.276  1.00 46.58  ? 924  ILE C CA  1 
ATOM   4493 C C   . ILE C 1 74  ? -57.273  42.189 54.585  1.00 50.53  ? 924  ILE C C   1 
ATOM   4494 O O   . ILE C 1 74  ? -58.257  41.784 55.173  1.00 56.08  ? 924  ILE C O   1 
ATOM   4495 C CB  . ILE C 1 74  ? -55.453  40.621 55.405  1.00 54.39  ? 924  ILE C CB  1 
ATOM   4496 C CG1 . ILE C 1 74  ? -54.381  40.457 56.481  1.00 53.78  ? 924  ILE C CG1 1 
ATOM   4497 C CG2 . ILE C 1 74  ? -54.989  40.089 54.059  1.00 58.02  ? 924  ILE C CG2 1 
ATOM   4498 C CD1 . ILE C 1 74  ? -53.015  40.912 56.053  1.00 59.07  ? 924  ILE C CD1 1 
ATOM   4499 N N   . LEU C 1 75  ? -57.296  42.798 53.410  1.00 48.10  ? 925  LEU C N   1 
ATOM   4500 C CA  . LEU C 1 75  ? -58.552  43.014 52.654  1.00 55.62  ? 925  LEU C CA  1 
ATOM   4501 C C   . LEU C 1 75  ? -58.806  41.783 51.800  1.00 65.83  ? 925  LEU C C   1 
ATOM   4502 O O   . LEU C 1 75  ? -58.062  41.590 50.834  1.00 68.31  ? 925  LEU C O   1 
ATOM   4503 C CB  . LEU C 1 75  ? -58.400  44.248 51.775  1.00 53.52  ? 925  LEU C CB  1 
ATOM   4504 C CG  . LEU C 1 75  ? -57.792  45.463 52.467  1.00 56.23  ? 925  LEU C CG  1 
ATOM   4505 C CD1 . LEU C 1 75  ? -57.594  46.604 51.486  1.00 56.69  ? 925  LEU C CD1 1 
ATOM   4506 C CD2 . LEU C 1 75  ? -58.664  45.905 53.625  1.00 46.24  ? 925  LEU C CD2 1 
ATOM   4507 N N   . PRO C 1 76  ? -59.861  40.997 52.074  1.00 71.19  ? 926  PRO C N   1 
ATOM   4508 C CA  . PRO C 1 76  ? -60.072  39.728 51.384  1.00 70.47  ? 926  PRO C CA  1 
ATOM   4509 C C   . PRO C 1 76  ? -60.320  39.747 49.882  1.00 68.49  ? 926  PRO C C   1 
ATOM   4510 O O   . PRO C 1 76  ? -60.258  40.789 49.298  1.00 65.72  ? 926  PRO C O   1 
ATOM   4511 C CB  . PRO C 1 76  ? -61.383  39.214 51.987  1.00 72.91  ? 926  PRO C CB  1 
ATOM   4512 C CG  . PRO C 1 76  ? -61.524  39.950 53.295  1.00 70.01  ? 926  PRO C CG  1 
ATOM   4513 C CD  . PRO C 1 76  ? -60.915  41.307 53.034  1.00 66.73  ? 926  PRO C CD  1 
ATOM   4514 N N   . LYS C 1 77  ? -60.557  38.555 49.324  1.00 76.28  ? 927  LYS C N   1 
ATOM   4515 C CA  . LYS C 1 77  ? -60.887  38.407 47.884  1.00 77.21  ? 927  LYS C CA  1 
ATOM   4516 C C   . LYS C 1 77  ? -62.120  39.239 47.537  1.00 72.54  ? 927  LYS C C   1 
ATOM   4517 O O   . LYS C 1 77  ? -62.124  39.865 46.483  1.00 70.02  ? 927  LYS C O   1 
ATOM   4518 C CB  . LYS C 1 77  ? -61.210  36.940 47.635  1.00 82.34  ? 927  LYS C CB  1 
ATOM   4519 C CG  . LYS C 1 77  ? -62.226  36.345 48.603  1.00 87.28  ? 927  LYS C CG  1 
ATOM   4520 C CD  . LYS C 1 77  ? -62.973  35.142 48.064  1.00 92.85  ? 927  LYS C CD  1 
ATOM   4521 C CE  . LYS C 1 77  ? -63.998  34.600 49.038  1.00 88.14  ? 927  LYS C CE  1 
ATOM   4522 N NZ  . LYS C 1 77  ? -64.524  33.283 48.612  1.00 82.31  ? 927  LYS C NZ  1 
ATOM   4523 N N   . THR C 1 78  ? -63.125  39.221 48.404  1.00 74.43  ? 928  THR C N   1 
ATOM   4524 C CA  . THR C 1 78  ? -64.300  40.094 48.211  1.00 69.78  ? 928  THR C CA  1 
ATOM   4525 C C   . THR C 1 78  ? -63.773  41.501 47.997  1.00 67.98  ? 928  THR C C   1 
ATOM   4526 O O   . THR C 1 78  ? -64.421  42.243 47.260  1.00 64.79  ? 928  THR C O   1 
ATOM   4527 C CB  . THR C 1 78  ? -65.165  40.096 49.465  1.00 68.15  ? 928  THR C CB  1 
ATOM   4528 O OG1 . THR C 1 78  ? -65.187  38.766 49.980  1.00 77.83  ? 928  THR C OG1 1 
ATOM   4529 C CG2 . THR C 1 78  ? -66.569  40.589 49.198  1.00 72.63  ? 928  THR C CG2 1 
ATOM   4530 N N   . GLY C 1 79  ? -62.627  41.829 48.610  1.00 67.18  ? 929  GLY C N   1 
ATOM   4531 C CA  . GLY C 1 79  ? -62.002  43.158 48.472  1.00 60.30  ? 929  GLY C CA  1 
ATOM   4532 C C   . GLY C 1 79  ? -62.746  44.199 49.271  1.00 58.21  ? 929  GLY C C   1 
ATOM   4533 O O   . GLY C 1 79  ? -62.684  45.360 48.875  1.00 56.69  ? 929  GLY C O   1 
ATOM   4534 N N   . THR C 1 80  ? -63.443  43.769 50.331  1.00 59.11  ? 930  THR C N   1 
ATOM   4535 C CA  . THR C 1 80  ? -64.278  44.666 51.164  1.00 52.12  ? 930  THR C CA  1 
ATOM   4536 C C   . THR C 1 80  ? -63.844  44.594 52.631  1.00 51.14  ? 930  THR C C   1 
ATOM   4537 O O   . THR C 1 80  ? -63.309  43.563 53.033  1.00 54.09  ? 930  THR C O   1 
ATOM   4538 C CB  . THR C 1 80  ? -65.749  44.275 51.032  1.00 51.00  ? 930  THR C CB  1 
ATOM   4539 O OG1 . THR C 1 80  ? -65.886  42.944 51.522  1.00 54.68  ? 930  THR C OG1 1 
ATOM   4540 C CG2 . THR C 1 80  ? -66.246  44.364 49.608  1.00 53.15  ? 930  THR C CG2 1 
ATOM   4541 N N   . VAL C 1 81  ? -64.066  45.657 53.389  1.00 44.54  ? 931  VAL C N   1 
ATOM   4542 C CA  . VAL C 1 81  ? -63.759  45.654 54.848  1.00 43.73  ? 931  VAL C CA  1 
ATOM   4543 C C   . VAL C 1 81  ? -64.532  46.810 55.477  1.00 37.30  ? 931  VAL C C   1 
ATOM   4544 O O   . VAL C 1 81  ? -64.688  47.828 54.822  1.00 37.32  ? 931  VAL C O   1 
ATOM   4545 C CB  . VAL C 1 81  ? -62.248  45.761 55.135  1.00 40.36  ? 931  VAL C CB  1 
ATOM   4546 C CG1 . VAL C 1 81  ? -61.659  47.052 54.601  1.00 45.37  ? 931  VAL C CG1 1 
ATOM   4547 C CG2 . VAL C 1 81  ? -61.941  45.598 56.610  1.00 45.51  ? 931  VAL C CG2 1 
ATOM   4548 N N   . SER C 1 82  ? -65.005  46.607 56.689  1.00 34.80  ? 932  SER C N   1 
ATOM   4549 C CA  A SER C 1 82  ? -65.652  47.718 57.425  0.54 34.12  ? 932  SER C CA  1 
ATOM   4550 C CA  B SER C 1 82  ? -65.626  47.706 57.376  0.46 34.11  ? 932  SER C CA  1 
ATOM   4551 C C   . SER C 1 82  ? -64.742  48.136 58.597  1.00 31.01  ? 932  SER C C   1 
ATOM   4552 O O   . SER C 1 82  ? -64.414  47.364 59.523  1.00 33.32  ? 932  SER C O   1 
ATOM   4553 C CB  A SER C 1 82  ? -67.039  47.358 57.891  0.54 36.93  ? 932  SER C CB  1 
ATOM   4554 C CB  B SER C 1 82  ? -66.999  47.237 57.858  0.46 36.95  ? 932  SER C CB  1 
ATOM   4555 O OG  A SER C 1 82  ? -67.851  46.964 56.799  0.54 38.05  ? 932  SER C OG  1 
ATOM   4556 O OG  B SER C 1 82  ? -67.667  48.246 58.590  0.46 36.47  ? 932  SER C OG  1 
ATOM   4557 N N   . LEU C 1 83  ? -64.308  49.388 58.535  1.00 28.12  ? 933  LEU C N   1 
ATOM   4558 C CA  . LEU C 1 83  ? -63.473  49.935 59.598  1.00 26.26  ? 933  LEU C CA  1 
ATOM   4559 C C   . LEU C 1 83  ? -64.263  50.977 60.376  1.00 25.78  ? 933  LEU C C   1 
ATOM   4560 O O   . LEU C 1 83  ? -64.816  51.903 59.781  1.00 27.95  ? 933  LEU C O   1 
ATOM   4561 C CB  . LEU C 1 83  ? -62.199  50.557 59.025  1.00 27.76  ? 933  LEU C CB  1 
ATOM   4562 C CG  . LEU C 1 83  ? -61.276  49.548 58.347  1.00 29.93  ? 933  LEU C CG  1 
ATOM   4563 C CD1 . LEU C 1 83  ? -60.121  50.246 57.655  1.00 33.73  ? 933  LEU C CD1 1 
ATOM   4564 C CD2 . LEU C 1 83  ? -60.768  48.549 59.371  1.00 31.40  ? 933  LEU C CD2 1 
ATOM   4565 N N   . GLU C 1 84  ? -64.324  50.830 61.695  1.00 25.74  ? 934  GLU C N   1 
ATOM   4566 C CA  . GLU C 1 84  ? -65.036  51.781 62.538  1.00 24.62  ? 934  GLU C CA  1 
ATOM   4567 C C   . GLU C 1 84  ? -64.046  52.694 63.250  1.00 27.88  ? 934  GLU C C   1 
ATOM   4568 O O   . GLU C 1 84  ? -63.071  52.218 63.834  1.00 28.61  ? 934  GLU C O   1 
ATOM   4569 C CB  . GLU C 1 84  ? -65.900  51.071 63.579  1.00 26.25  ? 934  GLU C CB  1 
ATOM   4570 C CG  . GLU C 1 84  ? -66.646  52.059 64.449  1.00 27.50  ? 934  GLU C CG  1 
ATOM   4571 C CD  . GLU C 1 84  ? -67.635  51.414 65.381  1.00 34.67  ? 934  GLU C CD  1 
ATOM   4572 O OE1 . GLU C 1 84  ? -68.352  50.481 64.963  1.00 34.70  ? 934  GLU C OE1 1 
ATOM   4573 O OE2 . GLU C 1 84  ? -67.691  51.866 66.538  1.00 34.35  ? 934  GLU C OE2 1 
ATOM   4574 N N   . VAL C 1 85  ? -64.309  53.997 63.218  1.00 25.06  ? 935  VAL C N   1 
ATOM   4575 C CA  . VAL C 1 85  ? -63.556  54.991 63.973  1.00 24.09  ? 935  VAL C CA  1 
ATOM   4576 C C   . VAL C 1 85  ? -64.464  55.519 65.074  1.00 26.78  ? 935  VAL C C   1 
ATOM   4577 O O   . VAL C 1 85  ? -65.612  55.891 64.814  1.00 25.19  ? 935  VAL C O   1 
ATOM   4578 C CB  . VAL C 1 85  ? -63.064  56.145 63.081  1.00 24.36  ? 935  VAL C CB  1 
ATOM   4579 C CG1 . VAL C 1 85  ? -62.257  57.145 63.907  1.00 24.79  ? 935  VAL C CG1 1 
ATOM   4580 C CG2 . VAL C 1 85  ? -62.253  55.623 61.901  1.00 26.68  ? 935  VAL C CG2 1 
ATOM   4581 N N   . ARG C 1 86  ? -63.955  55.540 66.300  1.00 23.99  ? 936  ARG C N   1 
ATOM   4582 C CA  . ARG C 1 86  ? -64.640  56.111 67.449  1.00 26.48  ? 936  ARG C CA  1 
ATOM   4583 C C   . ARG C 1 86  ? -63.794  57.231 68.035  1.00 28.02  ? 936  ARG C C   1 
ATOM   4584 O O   . ARG C 1 86  ? -62.579  57.080 68.189  1.00 28.28  ? 936  ARG C O   1 
ATOM   4585 C CB  . ARG C 1 86  ? -64.895  55.053 68.531  1.00 26.84  ? 936  ARG C CB  1 
ATOM   4586 C CG  . ARG C 1 86  ? -65.893  53.967 68.158  1.00 27.88  ? 936  ARG C CG  1 
ATOM   4587 C CD  . ARG C 1 86  ? -66.062  52.955 69.295  1.00 29.18  ? 936  ARG C CD  1 
ATOM   4588 N NE  . ARG C 1 86  ? -64.845  52.202 69.580  1.00 28.58  ? 936  ARG C NE  1 
ATOM   4589 C CZ  . ARG C 1 86  ? -64.477  51.098 68.943  1.00 32.61  ? 936  ARG C CZ  1 
ATOM   4590 N NH1 . ARG C 1 86  ? -65.216  50.577 67.977  1.00 30.20  ? 936  ARG C NH1 1 
ATOM   4591 N NH2 . ARG C 1 86  ? -63.340  50.497 69.287  1.00 31.62  ? 936  ARG C NH2 1 
ATOM   4592 N N   . LEU C 1 87  ? -64.431  58.354 68.358  1.00 26.66  ? 937  LEU C N   1 
ATOM   4593 C CA  . LEU C 1 87  ? -63.786  59.433 69.098  1.00 26.64  ? 937  LEU C CA  1 
ATOM   4594 C C   . LEU C 1 87  ? -64.245  59.341 70.548  1.00 28.88  ? 937  LEU C C   1 
ATOM   4595 O O   . LEU C 1 87  ? -65.450  59.325 70.815  1.00 27.36  ? 937  LEU C O   1 
ATOM   4596 C CB  . LEU C 1 87  ? -64.127  60.796 68.495  1.00 26.36  ? 937  LEU C CB  1 
ATOM   4597 C CG  . LEU C 1 87  ? -63.740  60.985 67.025  1.00 30.76  ? 937  LEU C CG  1 
ATOM   4598 C CD1 . LEU C 1 87  ? -63.989  62.414 66.558  1.00 30.00  ? 937  LEU C CD1 1 
ATOM   4599 C CD2 . LEU C 1 87  ? -62.281  60.607 66.819  1.00 28.03  ? 937  LEU C CD2 1 
ATOM   4600 N N   . LEU C 1 88  ? -63.297  59.232 71.478  1.00 26.74  ? 938  LEU C N   1 
ATOM   4601 C CA  . LEU C 1 88  ? -63.669  59.024 72.871  1.00 25.16  ? 938  LEU C CA  1 
ATOM   4602 C C   . LEU C 1 88  ? -64.311  60.275 73.465  1.00 29.00  ? 938  LEU C C   1 
ATOM   4603 O O   . LEU C 1 88  ? -63.983  61.406 73.101  1.00 29.48  ? 938  LEU C O   1 
ATOM   4604 C CB  . LEU C 1 88  ? -62.451  58.611 73.701  1.00 27.53  ? 938  LEU C CB  1 
ATOM   4605 C CG  . LEU C 1 88  ? -62.095  57.118 73.711  1.00 28.86  ? 938  LEU C CG  1 
ATOM   4606 C CD1 . LEU C 1 88  ? -61.570  56.629 72.360  1.00 28.33  ? 938  LEU C CD1 1 
ATOM   4607 C CD2 . LEU C 1 88  ? -61.111  56.798 74.831  1.00 31.99  ? 938  LEU C CD2 1 
ATOM   4608 N N   . GLU C 1 89  ? -65.244  60.052 74.390  1.00 28.01  ? 939  GLU C N   1 
ATOM   4609 C CA  . GLU C 1 89  ? -65.959  61.147 75.039  1.00 28.61  ? 939  GLU C CA  1 
ATOM   4610 C C   . GLU C 1 89  ? -64.995  62.054 75.799  1.00 31.76  ? 939  GLU C C   1 
ATOM   4611 O O   . GLU C 1 89  ? -64.100  61.576 76.503  1.00 31.63  ? 939  GLU C O   1 
ATOM   4612 C CB  . GLU C 1 89  ? -67.030  60.584 75.977  1.00 28.69  ? 939  GLU C CB  1 
ATOM   4613 C CG  . GLU C 1 89  ? -67.600  61.580 76.975  1.00 34.53  ? 939  GLU C CG  1 
ATOM   4614 C CD  . GLU C 1 89  ? -68.542  60.926 77.971  1.00 38.54  ? 939  GLU C CD  1 
ATOM   4615 O OE1 . GLU C 1 89  ? -69.678  60.575 77.584  1.00 33.70  ? 939  GLU C OE1 1 
ATOM   4616 O OE2 . GLU C 1 89  ? -68.137  60.743 79.137  1.00 36.42  ? 939  GLU C OE2 1 
ATOM   4617 N N   . ALA C 1 90  ? -65.173  63.368 75.628  1.00 31.67  ? 940  ALA C N   1 
ATOM   4618 C CA  . ALA C 1 90  ? -64.430  64.392 76.373  1.00 36.90  ? 940  ALA C CA  1 
ATOM   4619 C C   . ALA C 1 90  ? -62.923  64.176 76.275  1.00 37.04  ? 940  ALA C C   1 
ATOM   4620 O O   . ALA C 1 90  ? -62.179  64.370 77.239  1.00 39.00  ? 940  ALA C O   1 
ATOM   4621 C CB  . ALA C 1 90  ? -64.876  64.435 77.836  1.00 37.55  ? 940  ALA C CB  1 
ATOM   4622 N N   . SER C 1 91  ? -62.464  63.817 75.081  1.00 33.13  ? 941  SER C N   1 
ATOM   4623 C CA  . SER C 1 91  ? -61.085  63.393 74.897  1.00 28.94  ? 941  SER C CA  1 
ATOM   4624 C C   . SER C 1 91  ? -60.694  63.599 73.444  1.00 32.43  ? 941  SER C C   1 
ATOM   4625 O O   . SER C 1 91  ? -61.547  63.694 72.558  1.00 32.84  ? 941  SER C O   1 
ATOM   4626 C CB  . SER C 1 91  ? -60.903  61.923 75.299  1.00 31.88  ? 941  SER C CB  1 
ATOM   4627 O OG  . SER C 1 91  ? -59.616  61.441 74.954  1.00 34.78  ? 941  SER C OG  1 
ATOM   4628 N N   . ARG C 1 92  ? -59.387  63.694 73.220  1.00 30.63  ? 942  ARG C N   1 
ATOM   4629 C CA  . ARG C 1 92  ? -58.825  63.668 71.878  1.00 31.03  ? 942  ARG C CA  1 
ATOM   4630 C C   . ARG C 1 92  ? -58.522  62.255 71.406  1.00 27.42  ? 942  ARG C C   1 
ATOM   4631 O O   . ARG C 1 92  ? -58.114  62.073 70.254  1.00 29.05  ? 942  ARG C O   1 
ATOM   4632 C CB  . ARG C 1 92  ? -57.550  64.511 71.819  1.00 31.77  ? 942  ARG C CB  1 
ATOM   4633 C CG  . ARG C 1 92  ? -57.785  66.000 71.965  1.00 31.46  ? 942  ARG C CG  1 
ATOM   4634 C CD  . ARG C 1 92  ? -56.468  66.726 72.145  1.00 39.28  ? 942  ARG C CD  1 
ATOM   4635 N NE  . ARG C 1 92  ? -56.593  68.160 71.922  1.00 44.52  ? 942  ARG C NE  1 
ATOM   4636 C CZ  . ARG C 1 92  ? -55.577  69.010 71.955  1.00 46.09  ? 942  ARG C CZ  1 
ATOM   4637 N NH1 . ARG C 1 92  ? -54.351  68.610 72.250  1.00 43.75  ? 942  ARG C NH1 1 
ATOM   4638 N NH2 . ARG C 1 92  ? -55.795  70.293 71.683  1.00 42.91  ? 942  ARG C NH2 1 
ATOM   4639 N N   . ALA C 1 93  ? -58.692  61.260 72.272  1.00 27.82  ? 943  ALA C N   1 
ATOM   4640 C CA  . ALA C 1 93  ? -58.354  59.891 71.924  1.00 24.47  ? 943  ALA C CA  1 
ATOM   4641 C C   . ALA C 1 93  ? -59.310  59.342 70.871  1.00 27.81  ? 943  ALA C C   1 
ATOM   4642 O O   . ALA C 1 93  ? -60.486  59.715 70.805  1.00 30.15  ? 943  ALA C O   1 
ATOM   4643 C CB  . ALA C 1 93  ? -58.379  59.003 73.168  1.00 27.65  ? 943  ALA C CB  1 
ATOM   4644 N N   . PHE C 1 94  ? -58.789  58.442 70.039  1.00 25.43  ? 944  PHE C N   1 
ATOM   4645 C CA  . PHE C 1 94  ? -59.584  57.763 69.029  1.00 25.28  ? 944  PHE C CA  1 
ATOM   4646 C C   . PHE C 1 94  ? -59.263  56.275 69.043  1.00 28.11  ? 944  PHE C C   1 
ATOM   4647 O O   . PHE C 1 94  ? -58.214  55.844 69.529  1.00 26.95  ? 944  PHE C O   1 
ATOM   4648 C CB  . PHE C 1 94  ? -59.344  58.330 67.615  1.00 27.31  ? 944  PHE C CB  1 
ATOM   4649 C CG  . PHE C 1 94  ? -57.982  58.013 67.047  1.00 27.15  ? 944  PHE C CG  1 
ATOM   4650 C CD1 . PHE C 1 94  ? -57.762  56.837 66.340  1.00 27.34  ? 944  PHE C CD1 1 
ATOM   4651 C CD2 . PHE C 1 94  ? -56.929  58.899 67.200  1.00 26.66  ? 944  PHE C CD2 1 
ATOM   4652 C CE1 . PHE C 1 94  ? -56.513  56.543 65.820  1.00 28.29  ? 944  PHE C CE1 1 
ATOM   4653 C CE2 . PHE C 1 94  ? -55.680  58.613 66.676  1.00 27.12  ? 944  PHE C CE2 1 
ATOM   4654 C CZ  . PHE C 1 94  ? -55.472  57.434 65.986  1.00 27.53  ? 944  PHE C CZ  1 
ATOM   4655 N N   . GLU C 1 95  ? -60.185  55.497 68.481  1.00 23.97  ? 945  GLU C N   1 
ATOM   4656 C CA  . GLU C 1 95  ? -60.006  54.069 68.261  1.00 24.89  ? 945  GLU C CA  1 
ATOM   4657 C C   . GLU C 1 95  ? -60.458  53.728 66.850  1.00 27.39  ? 945  GLU C C   1 
ATOM   4658 O O   . GLU C 1 95  ? -61.396  54.333 66.329  1.00 26.67  ? 945  GLU C O   1 
ATOM   4659 C CB  . GLU C 1 95  ? -60.800  53.209 69.274  1.00 25.42  ? 945  GLU C CB  1 
ATOM   4660 C CG  . GLU C 1 95  ? -60.255  53.228 70.697  1.00 24.98  ? 945  GLU C CG  1 
ATOM   4661 C CD  . GLU C 1 95  ? -61.272  52.778 71.742  1.00 32.97  ? 945  GLU C CD  1 
ATOM   4662 O OE1 . GLU C 1 95  ? -62.330  52.225 71.370  1.00 31.50  ? 945  GLU C OE1 1 
ATOM   4663 O OE2 . GLU C 1 95  ? -61.018  53.005 72.944  1.00 33.74  ? 945  GLU C OE2 1 
ATOM   4664 N N   . VAL C 1 96  ? -59.767  52.782 66.224  1.00 25.16  ? 946  VAL C N   1 
ATOM   4665 C CA  . VAL C 1 96  ? -60.197  52.167 64.973  1.00 26.94  ? 946  VAL C CA  1 
ATOM   4666 C C   . VAL C 1 96  ? -60.338  50.678 65.228  1.00 27.84  ? 946  VAL C C   1 
ATOM   4667 O O   . VAL C 1 96  ? -59.451  50.071 65.831  1.00 28.94  ? 946  VAL C O   1 
ATOM   4668 C CB  . VAL C 1 96  ? -59.205  52.426 63.825  1.00 24.66  ? 946  VAL C CB  1 
ATOM   4669 C CG1 . VAL C 1 96  ? -59.723  51.810 62.533  1.00 26.49  ? 946  VAL C CG1 1 
ATOM   4670 C CG2 . VAL C 1 96  ? -58.972  53.909 63.651  1.00 24.92  ? 946  VAL C CG2 1 
ATOM   4671 N N   . SER C 1 97  ? -61.456  50.097 64.811  1.00 26.00  ? 947  SER C N   1 
ATOM   4672 C CA  . SER C 1 97  ? -61.690  48.678 65.016  1.00 27.67  ? 947  SER C CA  1 
ATOM   4673 C C   . SER C 1 97  ? -62.207  48.032 63.740  1.00 25.89  ? 947  SER C C   1 
ATOM   4674 O O   . SER C 1 97  ? -62.787  48.684 62.867  1.00 29.45  ? 947  SER C O   1 
ATOM   4675 C CB  . SER C 1 97  ? -62.686  48.420 66.156  1.00 34.21  ? 947  SER C CB  1 
ATOM   4676 O OG  . SER C 1 97  ? -63.933  49.038 65.893  1.00 28.78  ? 947  SER C OG  1 
ATOM   4677 N N   . GLU C 1 98  ? -61.988  46.726 63.652  1.00 27.85  ? 948  GLU C N   1 
ATOM   4678 C CA  . GLU C 1 98  ? -62.568  45.906 62.599  1.00 28.80  ? 948  GLU C CA  1 
ATOM   4679 C C   . GLU C 1 98  ? -63.143  44.660 63.244  1.00 35.83  ? 948  GLU C C   1 
ATOM   4680 O O   . GLU C 1 98  ? -62.432  43.958 63.970  1.00 34.18  ? 948  GLU C O   1 
ATOM   4681 C CB  . GLU C 1 98  ? -61.563  45.488 61.529  1.00 34.64  ? 948  GLU C CB  1 
ATOM   4682 C CG  . GLU C 1 98  ? -62.289  44.843 60.362  1.00 40.91  ? 948  GLU C CG  1 
ATOM   4683 C CD  . GLU C 1 98  ? -61.557  43.667 59.765  1.00 49.10  ? 948  GLU C CD  1 
ATOM   4684 O OE1 . GLU C 1 98  ? -60.595  43.175 60.390  1.00 54.90  ? 948  GLU C OE1 1 
ATOM   4685 O OE2 . GLU C 1 98  ? -61.971  43.212 58.680  1.00 54.50  ? 948  GLU C OE2 1 
ATOM   4686 N N   . ASN C 1 99  ? -64.424  44.394 62.994  1.00 38.66  ? 949  ASN C N   1 
ATOM   4687 C CA  . ASN C 1 99  ? -65.109  43.271 63.629  1.00 40.05  ? 949  ASN C CA  1 
ATOM   4688 C C   . ASN C 1 99  ? -64.981  43.342 65.145  1.00 37.83  ? 949  ASN C C   1 
ATOM   4689 O O   . ASN C 1 99  ? -64.887  42.316 65.821  1.00 45.13  ? 949  ASN C O   1 
ATOM   4690 C CB  . ASN C 1 99  ? -64.552  41.933 63.135  1.00 45.56  ? 949  ASN C CB  1 
ATOM   4691 C CG  . ASN C 1 99  ? -64.953  41.615 61.719  1.00 48.21  ? 949  ASN C CG  1 
ATOM   4692 O OD1 . ASN C 1 99  ? -65.804  42.282 61.135  1.00 54.85  ? 949  ASN C OD1 1 
ATOM   4693 N ND2 . ASN C 1 99  ? -64.322  40.597 61.147  1.00 62.02  ? 949  ASN C ND2 1 
ATOM   4694 N N   . GLY C 1 100 ? -64.960  44.553 65.696  1.00 36.48  ? 950  GLY C N   1 
ATOM   4695 C CA  . GLY C 1 100 ? -64.813  44.718 67.124  1.00 37.27  ? 950  GLY C CA  1 
ATOM   4696 C C   . GLY C 1 100 ? -63.395  44.628 67.650  1.00 42.48  ? 950  GLY C C   1 
ATOM   4697 O O   . GLY C 1 100 ? -63.162  44.998 68.808  1.00 46.89  ? 950  GLY C O   1 
ATOM   4698 N N   . ASN C 1 101 ? -62.445  44.122 66.863  1.00 37.00  ? 951  ASN C N   1 
ATOM   4699 C CA  . ASN C 1 101 ? -61.060  44.029 67.308  1.00 37.49  ? 951  ASN C CA  1 
ATOM   4700 C C   . ASN C 1 101 ? -60.366  45.373 67.141  1.00 33.57  ? 951  ASN C C   1 
ATOM   4701 O O   . ASN C 1 101 ? -60.476  46.009 66.086  1.00 32.47  ? 951  ASN C O   1 
ATOM   4702 C CB  . ASN C 1 101 ? -60.299  42.961 66.524  1.00 38.17  ? 951  ASN C CB  1 
ATOM   4703 C CG  . ASN C 1 101 ? -61.048  41.655 66.436  1.00 50.48  ? 951  ASN C CG  1 
ATOM   4704 O OD1 . ASN C 1 101 ? -61.130  41.048 65.369  1.00 55.24  ? 951  ASN C OD1 1 
ATOM   4705 N ND2 . ASN C 1 101 ? -61.613  41.218 67.555  1.00 50.15  ? 951  ASN C ND2 1 
ATOM   4706 N N   . LEU C 1 102 ? -59.622  45.781 68.169  1.00 30.31  ? 952  LEU C N   1 
ATOM   4707 C CA  . LEU C 1 102 ? -58.915  47.055 68.135  1.00 30.80  ? 952  LEU C CA  1 
ATOM   4708 C C   . LEU C 1 102 ? -57.757  46.982 67.149  1.00 33.89  ? 952  LEU C C   1 
ATOM   4709 O O   . LEU C 1 102 ? -56.920  46.077 67.218  1.00 30.94  ? 952  LEU C O   1 
ATOM   4710 C CB  . LEU C 1 102 ? -58.396  47.417 69.527  1.00 31.89  ? 952  LEU C CB  1 
ATOM   4711 C CG  . LEU C 1 102 ? -57.758  48.802 69.682  1.00 27.80  ? 952  LEU C CG  1 
ATOM   4712 C CD1 . LEU C 1 102 ? -58.773  49.913 69.445  1.00 32.37  ? 952  LEU C CD1 1 
ATOM   4713 C CD2 . LEU C 1 102 ? -57.099  48.952 71.046  1.00 32.67  ? 952  LEU C CD2 1 
ATOM   4714 N N   . VAL C 1 103 ? -57.724  47.931 66.219  1.00 28.77  ? 953  VAL C N   1 
ATOM   4715 C CA  . VAL C 1 103 ? -56.709  47.999 65.186  1.00 27.52  ? 953  VAL C CA  1 
ATOM   4716 C C   . VAL C 1 103 ? -55.750  49.163 65.412  1.00 27.68  ? 953  VAL C C   1 
ATOM   4717 O O   . VAL C 1 103 ? -54.538  49.011 65.245  1.00 28.68  ? 953  VAL C O   1 
ATOM   4718 C CB  . VAL C 1 103 ? -57.381  48.098 63.799  1.00 27.12  ? 953  VAL C CB  1 
ATOM   4719 C CG1 . VAL C 1 103 ? -56.339  48.215 62.705  1.00 28.97  ? 953  VAL C CG1 1 
ATOM   4720 C CG2 . VAL C 1 103 ? -58.289  46.898 63.564  1.00 29.92  ? 953  VAL C CG2 1 
ATOM   4721 N N   . VAL C 1 104 ? -56.274  50.338 65.772  1.00 25.03  ? 954  VAL C N   1 
ATOM   4722 C CA  . VAL C 1 104 ? -55.470  51.540 65.983  1.00 25.98  ? 954  VAL C CA  1 
ATOM   4723 C C   . VAL C 1 104 ? -56.002  52.285 67.200  1.00 28.24  ? 954  VAL C C   1 
ATOM   4724 O O   . VAL C 1 104 ? -57.214  52.329 67.433  1.00 27.68  ? 954  VAL C O   1 
ATOM   4725 C CB  . VAL C 1 104 ? -55.486  52.480 64.755  1.00 25.49  ? 954  VAL C CB  1 
ATOM   4726 C CG1 . VAL C 1 104 ? -54.454  53.593 64.916  1.00 27.70  ? 954  VAL C CG1 1 
ATOM   4727 C CG2 . VAL C 1 104 ? -55.250  51.715 63.466  1.00 28.19  ? 954  VAL C CG2 1 
ATOM   4728 N N   . SER C 1 105 ? -55.094  52.870 67.979  1.00 23.12  ? 955  SER C N   1 
ATOM   4729 C CA  . SER C 1 105 ? -55.468  53.824 69.011  1.00 25.80  ? 955  SER C CA  1 
ATOM   4730 C C   . SER C 1 105 ? -54.497  54.995 68.972  1.00 29.87  ? 955  SER C C   1 
ATOM   4731 O O   . SER C 1 105 ? -53.448  54.941 68.325  1.00 27.43  ? 955  SER C O   1 
ATOM   4732 C CB  . SER C 1 105 ? -55.482  53.185 70.402  1.00 30.92  ? 955  SER C CB  1 
ATOM   4733 O OG  . SER C 1 105 ? -54.213  52.644 70.710  1.00 30.83  ? 955  SER C OG  1 
ATOM   4734 N N   . GLY C 1 106 ? -54.869  56.072 69.649  1.00 27.25  ? 956  GLY C N   1 
ATOM   4735 C CA  . GLY C 1 106 ? -54.040  57.261 69.652  1.00 29.01  ? 956  GLY C CA  1 
ATOM   4736 C C   . GLY C 1 106 ? -54.885  58.487 69.933  1.00 29.75  ? 956  GLY C C   1 
ATOM   4737 O O   . GLY C 1 106 ? -56.014  58.384 70.409  1.00 25.86  ? 956  GLY C O   1 
ATOM   4738 N N   . LYS C 1 107 ? -54.308  59.644 69.622  1.00 24.88  ? 957  LYS C N   1 
ATOM   4739 C CA  . LYS C 1 107 ? -54.975  60.922 69.786  1.00 23.92  ? 957  LYS C CA  1 
ATOM   4740 C C   . LYS C 1 107 ? -54.939  61.662 68.459  1.00 27.54  ? 957  LYS C C   1 
ATOM   4741 O O   . LYS C 1 107 ? -53.992  61.525 67.682  1.00 26.32  ? 957  LYS C O   1 
ATOM   4742 C CB  . LYS C 1 107 ? -54.319  61.771 70.875  1.00 30.26  ? 957  LYS C CB  1 
ATOM   4743 C CG  . LYS C 1 107 ? -54.483  61.217 72.274  1.00 35.87  ? 957  LYS C CG  1 
ATOM   4744 C CD  . LYS C 1 107 ? -53.686  62.044 73.264  1.00 42.26  ? 957  LYS C CD  1 
ATOM   4745 C CE  . LYS C 1 107 ? -53.501  61.320 74.586  1.00 55.01  ? 957  LYS C CE  1 
ATOM   4746 N NZ  . LYS C 1 107 ? -54.088  62.088 75.719  1.00 59.23  ? 957  LYS C NZ  1 
ATOM   4747 N N   . VAL C 1 108 ? -55.984  62.441 68.201  1.00 28.57  ? 958  VAL C N   1 
ATOM   4748 C CA  . VAL C 1 108 ? -56.078  63.246 66.990  1.00 26.33  ? 958  VAL C CA  1 
ATOM   4749 C C   . VAL C 1 108 ? -56.758  64.559 67.357  1.00 31.18  ? 958  VAL C C   1 
ATOM   4750 O O   . VAL C 1 108 ? -57.684  64.578 68.175  1.00 29.95  ? 958  VAL C O   1 
ATOM   4751 C CB  . VAL C 1 108 ? -56.835  62.483 65.876  1.00 29.12  ? 958  VAL C CB  1 
ATOM   4752 C CG1 . VAL C 1 108 ? -58.284  62.201 66.279  1.00 28.05  ? 958  VAL C CG1 1 
ATOM   4753 C CG2 . VAL C 1 108 ? -56.757  63.217 64.548  1.00 29.09  ? 958  VAL C CG2 1 
ATOM   4754 N N   . TYR C 1 109 ? -56.275  65.665 66.791  1.00 28.81  ? 959  TYR C N   1 
ATOM   4755 C CA  . TYR C 1 109 ? -56.908  66.943 67.100  1.00 27.24  ? 959  TYR C CA  1 
ATOM   4756 C C   . TYR C 1 109 ? -56.608  67.977 66.024  1.00 31.92  ? 959  TYR C C   1 
ATOM   4757 O O   . TYR C 1 109 ? -55.620  67.885 65.288  1.00 30.32  ? 959  TYR C O   1 
ATOM   4758 C CB  . TYR C 1 109 ? -56.497  67.488 68.477  1.00 29.63  ? 959  TYR C CB  1 
ATOM   4759 C CG  . TYR C 1 109 ? -55.014  67.691 68.706  1.00 34.42  ? 959  TYR C CG  1 
ATOM   4760 C CD1 . TYR C 1 109 ? -54.208  66.647 69.137  1.00 33.39  ? 959  TYR C CD1 1 
ATOM   4761 C CD2 . TYR C 1 109 ? -54.428  68.938 68.522  1.00 37.10  ? 959  TYR C CD2 1 
ATOM   4762 C CE1 . TYR C 1 109 ? -52.854  66.834 69.364  1.00 36.23  ? 959  TYR C CE1 1 
ATOM   4763 C CE2 . TYR C 1 109 ? -53.074  69.135 68.744  1.00 40.03  ? 959  TYR C CE2 1 
ATOM   4764 C CZ  . TYR C 1 109 ? -52.293  68.079 69.166  1.00 39.94  ? 959  TYR C CZ  1 
ATOM   4765 O OH  . TYR C 1 109 ? -50.947  68.263 69.391  1.00 44.90  ? 959  TYR C OH  1 
ATOM   4766 N N   . GLN C 1 110 ? -57.505  68.959 65.944  1.00 31.27  ? 960  GLN C N   1 
ATOM   4767 C CA  . GLN C 1 110 ? -57.330  70.093 65.049  1.00 32.24  ? 960  GLN C CA  1 
ATOM   4768 C C   . GLN C 1 110 ? -56.077  70.880 65.407  1.00 30.64  ? 960  GLN C C   1 
ATOM   4769 O O   . GLN C 1 110 ? -55.871  71.256 66.565  1.00 34.62  ? 960  GLN C O   1 
ATOM   4770 C CB  . GLN C 1 110 ? -58.557  70.998 65.121  1.00 32.34  ? 960  GLN C CB  1 
ATOM   4771 C CG  . GLN C 1 110 ? -58.529  72.166 64.160  1.00 37.45  ? 960  GLN C CG  1 
ATOM   4772 C CD  . GLN C 1 110 ? -59.817  72.956 64.193  1.00 40.43  ? 960  GLN C CD  1 
ATOM   4773 O OE1 . GLN C 1 110 ? -60.573  72.890 65.163  1.00 40.52  ? 960  GLN C OE1 1 
ATOM   4774 N NE2 . GLN C 1 110 ? -60.087  73.694 63.124  1.00 47.28  ? 960  GLN C NE2 1 
ATOM   4775 N N   . TRP C 1 111 ? -55.258  71.160 64.398  1.00 34.37  ? 961  TRP C N   1 
ATOM   4776 C CA  . TRP C 1 111 ? -54.024  71.915 64.576  1.00 36.17  ? 961  TRP C CA  1 
ATOM   4777 C C   . TRP C 1 111 ? -54.344  73.400 64.451  1.00 40.60  ? 961  TRP C C   1 
ATOM   4778 O O   . TRP C 1 111 ? -54.582  73.901 63.348  1.00 38.64  ? 961  TRP C O   1 
ATOM   4779 C CB  . TRP C 1 111 ? -52.986  71.479 63.545  1.00 37.19  ? 961  TRP C CB  1 
ATOM   4780 C CG  . TRP C 1 111 ? -51.588  71.960 63.805  1.00 36.64  ? 961  TRP C CG  1 
ATOM   4781 C CD1 . TRP C 1 111 ? -51.132  72.622 64.909  1.00 41.33  ? 961  TRP C CD1 1 
ATOM   4782 C CD2 . TRP C 1 111 ? -50.458  71.797 62.940  1.00 37.50  ? 961  TRP C CD2 1 
ATOM   4783 N NE1 . TRP C 1 111 ? -49.789  72.888 64.779  1.00 37.13  ? 961  TRP C NE1 1 
ATOM   4784 C CE2 . TRP C 1 111 ? -49.352  72.391 63.579  1.00 39.36  ? 961  TRP C CE2 1 
ATOM   4785 C CE3 . TRP C 1 111 ? -50.277  71.209 61.685  1.00 39.67  ? 961  TRP C CE3 1 
ATOM   4786 C CZ2 . TRP C 1 111 ? -48.083  72.413 63.005  1.00 38.21  ? 961  TRP C CZ2 1 
ATOM   4787 C CZ3 . TRP C 1 111 ? -49.017  71.232 61.117  1.00 40.94  ? 961  TRP C CZ3 1 
ATOM   4788 C CH2 . TRP C 1 111 ? -47.937  71.830 61.776  1.00 34.93  ? 961  TRP C CH2 1 
ATOM   4789 N N   . ASP C 1 112 ? -54.351  74.101 65.582  1.00 45.16  ? 962  ASP C N   1 
ATOM   4790 C CA  . ASP C 1 112 ? -54.662  75.523 65.592  1.00 51.68  ? 962  ASP C CA  1 
ATOM   4791 C C   . ASP C 1 112 ? -53.442  76.303 65.117  1.00 49.56  ? 962  ASP C C   1 
ATOM   4792 O O   . ASP C 1 112 ? -52.330  76.077 65.605  1.00 50.01  ? 962  ASP C O   1 
ATOM   4793 C CB  . ASP C 1 112 ? -55.086  75.969 66.992  1.00 49.78  ? 962  ASP C CB  1 
ATOM   4794 C CG  . ASP C 1 112 ? -56.484  75.497 67.357  1.00 55.37  ? 962  ASP C CG  1 
ATOM   4795 O OD1 . ASP C 1 112 ? -57.239  75.100 66.443  1.00 55.40  ? 962  ASP C OD1 1 
ATOM   4796 O OD2 . ASP C 1 112 ? -56.827  75.523 68.557  1.00 61.80  ? 962  ASP C OD2 1 
ATOM   4797 N N   . ASP C 1 113 ? -53.665  77.228 64.164  1.00 57.54  ? 963  ASP C N   1 
ATOM   4798 C CA  . ASP C 1 113 ? -52.666  78.011 63.428  1.00 60.45  ? 963  ASP C CA  1 
ATOM   4799 C C   . ASP C 1 113 ? -51.345  77.259 63.281  1.00 56.66  ? 963  ASP C C   1 
ATOM   4800 O O   . ASP C 1 113 ? -50.426  77.431 64.092  1.00 59.02  ? 963  ASP C O   1 
ATOM   4801 C CB  . ASP C 1 113 ? -52.433  79.400 64.036  1.00 61.10  ? 963  ASP C CB  1 
ATOM   4802 C CG  . ASP C 1 113 ? -52.441  79.402 65.539  1.00 67.81  ? 963  ASP C CG  1 
ATOM   4803 O OD1 . ASP C 1 113 ? -51.634  78.669 66.140  1.00 70.24  ? 963  ASP C OD1 1 
ATOM   4804 O OD2 . ASP C 1 113 ? -53.252  80.151 66.123  1.00 71.33  ? 963  ASP C OD2 1 
ATOM   4805 N N   . PRO C 1 114 ? -51.258  76.353 62.309  1.00 47.06  ? 964  PRO C N   1 
ATOM   4806 C CA  . PRO C 1 114 ? -50.020  75.591 62.096  1.00 46.17  ? 964  PRO C CA  1 
ATOM   4807 C C   . PRO C 1 114 ? -48.823  76.487 61.809  1.00 50.57  ? 964  PRO C C   1 
ATOM   4808 O O   . PRO C 1 114 ? -48.950  77.577 61.245  1.00 51.80  ? 964  PRO C O   1 
ATOM   4809 C CB  . PRO C 1 114 ? -50.338  74.711 60.880  1.00 46.68  ? 964  PRO C CB  1 
ATOM   4810 C CG  . PRO C 1 114 ? -51.798  74.771 60.688  1.00 47.38  ? 964  PRO C CG  1 
ATOM   4811 C CD  . PRO C 1 114 ? -52.338  75.969 61.386  1.00 45.20  ? 964  PRO C CD  1 
ATOM   4812 N N   . ASP C 1 115 ? -47.644  76.005 62.203  1.00 47.82  ? 965  ASP C N   1 
ATOM   4813 C CA  . ASP C 1 115 ? -46.400  76.726 61.984  1.00 44.39  ? 965  ASP C CA  1 
ATOM   4814 C C   . ASP C 1 115 ? -45.716  76.070 60.794  1.00 41.30  ? 965  ASP C C   1 
ATOM   4815 O O   . ASP C 1 115 ? -45.211  74.945 60.928  1.00 45.60  ? 965  ASP C O   1 
ATOM   4816 C CB  . ASP C 1 115 ? -45.510  76.654 63.230  1.00 45.06  ? 965  ASP C CB  1 
ATOM   4817 C CG  . ASP C 1 115 ? -44.119  77.264 63.028  1.00 54.16  ? 965  ASP C CG  1 
ATOM   4818 O OD1 . ASP C 1 115 ? -43.692  77.512 61.883  1.00 54.35  ? 965  ASP C OD1 1 
ATOM   4819 O OD2 . ASP C 1 115 ? -43.431  77.483 64.047  1.00 57.35  ? 965  ASP C OD2 1 
ATOM   4820 N N   . PRO C 1 116 ? -45.689  76.708 59.620  1.00 46.86  ? 966  PRO C N   1 
ATOM   4821 C CA  . PRO C 1 116 ? -45.086  76.057 58.441  1.00 44.32  ? 966  PRO C CA  1 
ATOM   4822 C C   . PRO C 1 116 ? -43.608  75.732 58.605  1.00 40.61  ? 966  PRO C C   1 
ATOM   4823 O O   . PRO C 1 116 ? -43.096  74.867 57.878  1.00 43.67  ? 966  PRO C O   1 
ATOM   4824 C CB  . PRO C 1 116 ? -45.334  77.058 57.302  1.00 50.00  ? 966  PRO C CB  1 
ATOM   4825 C CG  . PRO C 1 116 ? -45.703  78.340 57.940  1.00 52.28  ? 966  PRO C CG  1 
ATOM   4826 C CD  . PRO C 1 116 ? -46.093  78.102 59.366  1.00 49.58  ? 966  PRO C CD  1 
ATOM   4827 N N   . ARG C 1 117 ? -42.908  76.385 59.539  1.00 49.09  ? 967  ARG C N   1 
ATOM   4828 C CA  . ARG C 1 117 ? -41.497  76.083 59.755  1.00 53.95  ? 967  ARG C CA  1 
ATOM   4829 C C   . ARG C 1 117 ? -41.288  74.642 60.190  1.00 50.69  ? 967  ARG C C   1 
ATOM   4830 O O   . ARG C 1 117 ? -40.169  74.128 60.076  1.00 46.58  ? 967  ARG C O   1 
ATOM   4831 C CB  . ARG C 1 117 ? -40.895  77.030 60.800  1.00 47.41  ? 967  ARG C CB  1 
ATOM   4832 C CG  . ARG C 1 117 ? -40.750  78.492 60.366  1.00 55.05  ? 967  ARG C CG  1 
ATOM   4833 C CD  . ARG C 1 117 ? -39.790  78.674 59.191  1.00 55.54  ? 967  ARG C CD  1 
ATOM   4834 N NE  . ARG C 1 117 ? -40.346  78.221 57.921  1.00 58.31  ? 967  ARG C NE  1 
ATOM   4835 C CZ  . ARG C 1 117 ? -41.183  78.924 57.172  1.00 56.58  ? 967  ARG C CZ  1 
ATOM   4836 N NH1 . ARG C 1 117 ? -41.542  80.153 57.504  1.00 62.14  ? 967  ARG C NH1 1 
ATOM   4837 N NH2 . ARG C 1 117 ? -41.669  78.382 56.059  1.00 56.23  ? 967  ARG C NH2 1 
ATOM   4838 N N   . LEU C 1 118 ? -42.333  73.981 60.694  1.00 48.06  ? 968  LEU C N   1 
ATOM   4839 C CA  . LEU C 1 118 ? -42.197  72.578 61.065  1.00 40.26  ? 968  LEU C CA  1 
ATOM   4840 C C   . LEU C 1 118 ? -41.802  71.728 59.865  1.00 39.92  ? 968  LEU C C   1 
ATOM   4841 O O   . LEU C 1 118 ? -41.143  70.694 60.025  1.00 41.36  ? 968  LEU C O   1 
ATOM   4842 C CB  . LEU C 1 118 ? -43.501  72.065 61.679  1.00 41.33  ? 968  LEU C CB  1 
ATOM   4843 C CG  . LEU C 1 118 ? -43.503  70.584 62.059  1.00 41.07  ? 968  LEU C CG  1 
ATOM   4844 C CD1 . LEU C 1 118 ? -42.383  70.312 63.051  1.00 43.56  ? 968  LEU C CD1 1 
ATOM   4845 C CD2 . LEU C 1 118 ? -44.843  70.166 62.630  1.00 42.72  ? 968  LEU C CD2 1 
ATOM   4846 N N   . PHE C 1 119 ? -42.152  72.164 58.656  1.00 36.91  ? 969  PHE C N   1 
ATOM   4847 C CA  . PHE C 1 119 ? -41.904  71.372 57.461  1.00 41.75  ? 969  PHE C CA  1 
ATOM   4848 C C   . PHE C 1 119 ? -40.581  71.722 56.791  1.00 43.07  ? 969  PHE C C   1 
ATOM   4849 O O   . PHE C 1 119 ? -40.292  71.210 55.704  1.00 45.60  ? 969  PHE C O   1 
ATOM   4850 C CB  . PHE C 1 119 ? -43.090  71.498 56.507  1.00 41.08  ? 969  PHE C CB  1 
ATOM   4851 C CG  . PHE C 1 119 ? -44.390  71.110 57.151  1.00 40.25  ? 969  PHE C CG  1 
ATOM   4852 C CD1 . PHE C 1 119 ? -44.715  69.774 57.329  1.00 38.43  ? 969  PHE C CD1 1 
ATOM   4853 C CD2 . PHE C 1 119 ? -45.255  72.074 57.637  1.00 38.60  ? 969  PHE C CD2 1 
ATOM   4854 C CE1 . PHE C 1 119 ? -45.892  69.410 57.955  1.00 34.63  ? 969  PHE C CE1 1 
ATOM   4855 C CE2 . PHE C 1 119 ? -46.438  71.714 58.257  1.00 43.03  ? 969  PHE C CE2 1 
ATOM   4856 C CZ  . PHE C 1 119 ? -46.758  70.380 58.412  1.00 37.87  ? 969  PHE C CZ  1 
ATOM   4857 N N   . ASP C 1 120 ? -39.792  72.541 57.473  1.00 47.96  ? 970  ASP C N   1 
ATOM   4858 C CA  . ASP C 1 120 ? -38.428  72.863 56.989  1.00 48.85  ? 970  ASP C CA  1 
ATOM   4859 C C   . ASP C 1 120 ? -37.601  71.582 57.077  1.00 51.40  ? 970  ASP C C   1 
ATOM   4860 O O   . ASP C 1 120 ? -37.536  71.000 58.153  1.00 51.30  ? 970  ASP C O   1 
ATOM   4861 C CB  . ASP C 1 120 ? -37.845  74.028 57.790  1.00 49.17  ? 970  ASP C CB  1 
ATOM   4862 C CG  . ASP C 1 120 ? -38.479  75.373 57.504  1.00 50.82  ? 970  ASP C CG  1 
ATOM   4863 O OD1 . ASP C 1 120 ? -39.221  75.477 56.518  1.00 51.72  ? 970  ASP C OD1 1 
ATOM   4864 O OD2 . ASP C 1 120 ? -38.238  76.292 58.290  1.00 54.34  ? 970  ASP C OD2 1 
ATOM   4865 N N   . HIS C 1 121 ? -37.033  71.154 55.969  1.00 45.15  ? 971  HIS C N   1 
ATOM   4866 C CA  . HIS C 1 121 ? -36.290  69.879 55.952  1.00 51.32  ? 971  HIS C CA  1 
ATOM   4867 C C   . HIS C 1 121 ? -35.085  69.968 56.880  1.00 55.65  ? 971  HIS C C   1 
ATOM   4868 O O   . HIS C 1 121 ? -34.339  70.949 56.867  1.00 56.15  ? 971  HIS C O   1 
ATOM   4869 C CB  . HIS C 1 121 ? -35.912  69.479 54.523  1.00 52.22  ? 971  HIS C CB  1 
ATOM   4870 C CG  . HIS C 1 121 ? -37.065  69.222 53.623  1.00 49.20  ? 971  HIS C CG  1 
ATOM   4871 N ND1 . HIS C 1 121 ? -36.897  68.747 52.344  1.00 48.96  ? 971  HIS C ND1 1 
ATOM   4872 C CD2 . HIS C 1 121 ? -38.377  69.342 53.806  1.00 47.25  ? 971  HIS C CD2 1 
ATOM   4873 C CE1 . HIS C 1 121 ? -38.080  68.598 51.781  1.00 48.18  ? 971  HIS C CE1 1 
ATOM   4874 N NE2 . HIS C 1 121 ? -38.989  68.960 52.649  1.00 47.12  ? 971  HIS C NE2 1 
ATOM   4875 N N   . PRO C 1 122 ? -34.872  68.933 57.704  1.00 50.69  ? 972  PRO C N   1 
ATOM   4876 C CA  . PRO C 1 122 ? -33.719  68.901 58.576  1.00 56.84  ? 972  PRO C CA  1 
ATOM   4877 C C   . PRO C 1 122 ? -32.432  68.785 57.748  1.00 55.56  ? 972  PRO C C   1 
ATOM   4878 O O   . PRO C 1 122 ? -32.440  68.139 56.736  1.00 46.43  ? 972  PRO C O   1 
ATOM   4879 C CB  . PRO C 1 122 ? -33.967  67.643 59.407  1.00 51.07  ? 972  PRO C CB  1 
ATOM   4880 C CG  . PRO C 1 122 ? -34.833  66.779 58.536  1.00 51.39  ? 972  PRO C CG  1 
ATOM   4881 C CD  . PRO C 1 122 ? -35.736  67.767 57.837  1.00 53.19  ? 972  PRO C CD  1 
ATOM   4882 N N   . GLU C 1 123 ? -31.363  69.416 58.234  1.00 60.26  ? 973  GLU C N   1 
ATOM   4883 C CA  . GLU C 1 123 ? -30.065  69.419 57.514  1.00 62.53  ? 973  GLU C CA  1 
ATOM   4884 C C   . GLU C 1 123 ? -28.942  68.888 58.404  1.00 60.51  ? 973  GLU C C   1 
ATOM   4885 O O   . GLU C 1 123 ? -28.861  69.278 59.565  1.00 57.34  ? 973  GLU C O   1 
ATOM   4886 C CB  . GLU C 1 123 ? -29.709  70.840 57.083  1.00 68.28  ? 973  GLU C CB  1 
ATOM   4887 C CG  . GLU C 1 123 ? -30.503  71.320 55.886  1.00 73.62  ? 973  GLU C CG  1 
ATOM   4888 C CD  . GLU C 1 123 ? -30.381  72.804 55.589  1.00 81.13  ? 973  GLU C CD  1 
ATOM   4889 O OE1 . GLU C 1 123 ? -29.742  73.518 56.383  1.00 81.17  ? 973  GLU C OE1 1 
ATOM   4890 O OE2 . GLU C 1 123 ? -30.919  73.236 54.557  1.00 80.40  ? 973  GLU C OE2 1 
ATOM   4891 N N   . SER C 1 124 ? -28.132  68.008 57.845  1.00 60.29  ? 974  SER C N   1 
ATOM   4892 C CA  . SER C 1 124 ? -26.956  67.498 58.581  1.00 68.19  ? 974  SER C CA  1 
ATOM   4893 C C   . SER C 1 124 ? -26.028  68.666 58.901  1.00 76.96  ? 974  SER C C   1 
ATOM   4894 O O   . SER C 1 124 ? -25.859  69.531 58.034  1.00 75.79  ? 974  SER C O   1 
ATOM   4895 C CB  . SER C 1 124 ? -26.253  66.473 57.748  1.00 65.62  ? 974  SER C CB  1 
ATOM   4896 O OG  . SER C 1 124 ? -26.104  66.930 56.415  1.00 78.96  ? 974  SER C OG  1 
ATOM   4897 N N   . PRO C 1 125 ? -25.443  68.740 60.107  1.00 79.51  ? 975  PRO C N   1 
ATOM   4898 C CA  . PRO C 1 125 ? -24.467  69.781 60.407  1.00 82.93  ? 975  PRO C CA  1 
ATOM   4899 C C   . PRO C 1 125 ? -23.517  70.029 59.230  1.00 85.58  ? 975  PRO C C   1 
ATOM   4900 O O   . PRO C 1 125 ? -23.092  71.143 59.084  1.00 92.42  ? 975  PRO C O   1 
ATOM   4901 C CB  . PRO C 1 125 ? -23.702  69.137 61.559  1.00 84.05  ? 975  PRO C CB  1 
ATOM   4902 C CG  . PRO C 1 125 ? -24.785  68.406 62.321  1.00 78.90  ? 975  PRO C CG  1 
ATOM   4903 C CD  . PRO C 1 125 ? -25.710  67.869 61.247  1.00 73.96  ? 975  PRO C CD  1 
ATOM   4904 N N   . THR C 1 126 ? -23.237  69.012 58.421  1.00 84.07  ? 976  THR C N   1 
ATOM   4905 C CA  . THR C 1 126 ? -22.384  69.183 57.217  1.00 85.25  ? 976  THR C CA  1 
ATOM   4906 C C   . THR C 1 126 ? -23.251  69.393 55.974  1.00 81.30  ? 976  THR C C   1 
ATOM   4907 O O   . THR C 1 126 ? -23.745  68.387 55.452  1.00 82.55  ? 976  THR C O   1 
ATOM   4908 C CB  . THR C 1 126 ? -21.433  67.990 57.085  1.00 83.08  ? 976  THR C CB  1 
ATOM   4909 O OG1 . THR C 1 126 ? -22.180  66.851 56.658  1.00 84.92  ? 976  THR C OG1 1 
ATOM   4910 C CG2 . THR C 1 126 ? -20.725  67.683 58.386  1.00 78.67  ? 976  THR C CG2 1 
ATOM   4911 N N   . PHE C 1 134 ? -27.852  58.613 42.216  1.00 73.17  ? 984  PHE C N   1 
ATOM   4912 C CA  . PHE C 1 134 ? -29.212  58.477 42.798  1.00 62.70  ? 984  PHE C CA  1 
ATOM   4913 C C   . PHE C 1 134 ? -29.888  57.235 42.226  1.00 67.94  ? 984  PHE C C   1 
ATOM   4914 O O   . PHE C 1 134 ? -29.428  56.717 41.209  1.00 63.75  ? 984  PHE C O   1 
ATOM   4915 C CB  . PHE C 1 134 ? -30.042  59.737 42.562  1.00 64.71  ? 984  PHE C CB  1 
ATOM   4916 C CG  . PHE C 1 134 ? -30.645  59.884 41.188  1.00 71.86  ? 984  PHE C CG  1 
ATOM   4917 C CD1 . PHE C 1 134 ? -30.087  60.747 40.259  1.00 77.07  ? 984  PHE C CD1 1 
ATOM   4918 C CD2 . PHE C 1 134 ? -31.803  59.209 40.843  1.00 65.75  ? 984  PHE C CD2 1 
ATOM   4919 C CE1 . PHE C 1 134 ? -30.651  60.901 39.003  1.00 70.30  ? 984  PHE C CE1 1 
ATOM   4920 C CE2 . PHE C 1 134 ? -32.370  59.367 39.590  1.00 66.69  ? 984  PHE C CE2 1 
ATOM   4921 C CZ  . PHE C 1 134 ? -31.792  60.210 38.672  1.00 73.43  ? 984  PHE C CZ  1 
ATOM   4922 N N   . LEU C 1 135 ? -30.927  56.752 42.906  1.00 57.25  ? 985  LEU C N   1 
ATOM   4923 C CA  . LEU C 1 135 ? -31.687  55.585 42.403  1.00 59.39  ? 985  LEU C CA  1 
ATOM   4924 C C   . LEU C 1 135 ? -32.980  56.071 41.759  1.00 60.16  ? 985  LEU C C   1 
ATOM   4925 O O   . LEU C 1 135 ? -33.638  56.934 42.331  1.00 51.44  ? 985  LEU C O   1 
ATOM   4926 C CB  . LEU C 1 135 ? -32.033  54.634 43.548  1.00 59.93  ? 985  LEU C CB  1 
ATOM   4927 C CG  . LEU C 1 135 ? -30.896  53.789 44.111  1.00 65.41  ? 985  LEU C CG  1 
ATOM   4928 C CD1 . LEU C 1 135 ? -30.331  54.432 45.362  1.00 65.37  ? 985  LEU C CD1 1 
ATOM   4929 C CD2 . LEU C 1 135 ? -31.385  52.384 44.414  1.00 64.17  ? 985  LEU C CD2 1 
ATOM   4930 N N   . ALA C 1 136 ? -33.307  55.501 40.612  1.00 55.40  ? 986  ALA C N   1 
ATOM   4931 C CA  . ALA C 1 136 ? -34.561  55.858 39.937  1.00 54.99  ? 986  ALA C CA  1 
ATOM   4932 C C   . ALA C 1 136 ? -35.685  54.958 40.440  1.00 52.22  ? 986  ALA C C   1 
ATOM   4933 O O   . ALA C 1 136 ? -35.394  53.936 41.056  1.00 49.83  ? 986  ALA C O   1 
ATOM   4934 C CB  . ALA C 1 136 ? -34.390  55.721 38.458  1.00 57.18  ? 986  ALA C CB  1 
ATOM   4935 N N   . GLN C 1 137 ? -36.918  55.304 40.104  1.00 57.21  ? 987  GLN C N   1 
ATOM   4936 C CA  . GLN C 1 137 ? -38.110  54.561 40.569  1.00 49.59  ? 987  GLN C CA  1 
ATOM   4937 C C   . GLN C 1 137 ? -37.951  53.064 40.386  1.00 54.48  ? 987  GLN C C   1 
ATOM   4938 O O   . GLN C 1 137 ? -38.133  52.340 41.350  1.00 52.04  ? 987  GLN C O   1 
ATOM   4939 C CB  . GLN C 1 137 ? -39.308  55.016 39.746  1.00 52.84  ? 987  GLN C CB  1 
ATOM   4940 C CG  . GLN C 1 137 ? -40.619  54.364 40.148  1.00 48.27  ? 987  GLN C CG  1 
ATOM   4941 C CD  . GLN C 1 137 ? -41.774  54.944 39.374  1.00 52.94  ? 987  GLN C CD  1 
ATOM   4942 O OE1 . GLN C 1 137 ? -42.686  55.541 39.936  1.00 55.23  ? 987  GLN C OE1 1 
ATOM   4943 N NE2 . GLN C 1 137 ? -41.733  54.789 38.064  1.00 58.87  ? 987  GLN C NE2 1 
ATOM   4944 N N   . ALA C 1 138 ? -37.623  52.629 39.182  1.00 53.85  ? 988  ALA C N   1 
ATOM   4945 C CA  . ALA C 1 138 ? -37.607  51.179 38.922  1.00 54.22  ? 988  ALA C CA  1 
ATOM   4946 C C   . ALA C 1 138 ? -36.656  50.443 39.862  1.00 54.45  ? 988  ALA C C   1 
ATOM   4947 O O   . ALA C 1 138 ? -36.975  49.332 40.269  1.00 55.58  ? 988  ALA C O   1 
ATOM   4948 C CB  . ALA C 1 138 ? -37.246  50.964 37.492  1.00 55.73  ? 988  ALA C CB  1 
ATOM   4949 N N   . GLU C 1 139 ? -35.523  51.051 40.170  1.00 55.82  ? 989  GLU C N   1 
ATOM   4950 C CA  . GLU C 1 139 ? -34.509  50.377 41.013  1.00 57.15  ? 989  GLU C CA  1 
ATOM   4951 C C   . GLU C 1 139 ? -34.997  50.387 42.463  1.00 54.39  ? 989  GLU C C   1 
ATOM   4952 O O   . GLU C 1 139 ? -34.778  49.409 43.172  1.00 51.54  ? 989  GLU C O   1 
ATOM   4953 C CB  . GLU C 1 139 ? -33.163  51.076 40.835  1.00 54.35  ? 989  GLU C CB  1 
ATOM   4954 C CG  . GLU C 1 139 ? -32.310  50.442 39.757  1.00 65.26  ? 989  GLU C CG  1 
ATOM   4955 C CD  . GLU C 1 139 ? -33.030  50.194 38.444  1.00 68.91  ? 989  GLU C CD  1 
ATOM   4956 O OE1 . GLU C 1 139 ? -33.431  51.174 37.797  1.00 70.22  ? 989  GLU C OE1 1 
ATOM   4957 O OE2 . GLU C 1 139 ? -33.197  49.019 38.080  1.00 75.96  ? 989  GLU C OE2 1 
ATOM   4958 N N   . VAL C 1 140 ? -35.676  51.460 42.840  1.00 52.73  ? 990  VAL C N   1 
ATOM   4959 C CA  . VAL C 1 140 ? -36.239  51.558 44.214  1.00 51.17  ? 990  VAL C CA  1 
ATOM   4960 C C   . VAL C 1 140 ? -37.208  50.405 44.439  1.00 46.20  ? 990  VAL C C   1 
ATOM   4961 O O   . VAL C 1 140 ? -37.068  49.725 45.444  1.00 47.66  ? 990  VAL C O   1 
ATOM   4962 C CB  . VAL C 1 140 ? -36.906  52.925 44.416  1.00 46.59  ? 990  VAL C CB  1 
ATOM   4963 C CG1 . VAL C 1 140 ? -37.769  52.955 45.667  1.00 44.41  ? 990  VAL C CG1 1 
ATOM   4964 C CG2 . VAL C 1 140 ? -35.899  54.061 44.429  1.00 43.65  ? 990  VAL C CG2 1 
ATOM   4965 N N   . TYR C 1 141 ? -38.099  50.157 43.489  1.00 48.05  ? 991  TYR C N   1 
ATOM   4966 C CA  . TYR C 1 141 ? -39.155  49.145 43.743  1.00 47.11  ? 991  TYR C CA  1 
ATOM   4967 C C   . TYR C 1 141 ? -38.576  47.734 43.612  1.00 52.97  ? 991  TYR C C   1 
ATOM   4968 O O   . TYR C 1 141 ? -39.103  46.818 44.232  1.00 48.06  ? 991  TYR C O   1 
ATOM   4969 C CB  . TYR C 1 141 ? -40.422  49.549 42.980  1.00 43.96  ? 991  TYR C CB  1 
ATOM   4970 C CG  . TYR C 1 141 ? -41.069  50.743 43.633  1.00 44.72  ? 991  TYR C CG  1 
ATOM   4971 C CD1 . TYR C 1 141 ? -41.710  50.619 44.853  1.00 41.93  ? 991  TYR C CD1 1 
ATOM   4972 C CD2 . TYR C 1 141 ? -40.940  52.014 43.102  1.00 42.46  ? 991  TYR C CD2 1 
ATOM   4973 C CE1 . TYR C 1 141 ? -42.265  51.712 45.494  1.00 36.72  ? 991  TYR C CE1 1 
ATOM   4974 C CE2 . TYR C 1 141 ? -41.485  53.119 43.732  1.00 42.78  ? 991  TYR C CE2 1 
ATOM   4975 C CZ  . TYR C 1 141 ? -42.151  52.968 44.934  1.00 38.43  ? 991  TYR C CZ  1 
ATOM   4976 O OH  . TYR C 1 141 ? -42.699  54.055 45.561  1.00 38.73  ? 991  TYR C OH  1 
ATOM   4977 N N   . LYS C 1 142 ? -37.480  47.592 42.876  1.00 54.98  ? 992  LYS C N   1 
ATOM   4978 C CA  . LYS C 1 142 ? -36.787  46.284 42.805  1.00 52.45  ? 992  LYS C CA  1 
ATOM   4979 C C   . LYS C 1 142 ? -36.196  45.974 44.177  1.00 46.11  ? 992  LYS C C   1 
ATOM   4980 O O   . LYS C 1 142 ? -36.337  44.853 44.642  1.00 52.26  ? 992  LYS C O   1 
ATOM   4981 C CB  . LYS C 1 142 ? -35.691  46.387 41.740  1.00 60.73  ? 992  LYS C CB  1 
ATOM   4982 C CG  . LYS C 1 142 ? -34.611  45.316 41.754  1.00 64.95  ? 992  LYS C CG  1 
ATOM   4983 C CD  . LYS C 1 142 ? -33.573  45.590 40.683  1.00 77.51  ? 992  LYS C CD  1 
ATOM   4984 C CE  . LYS C 1 142 ? -32.327  44.738 40.781  1.00 79.17  ? 992  LYS C CE  1 
ATOM   4985 N NZ  . LYS C 1 142 ? -31.389  45.034 39.673  1.00 72.31  ? 992  LYS C NZ  1 
ATOM   4986 N N   . GLU C 1 143 ? -35.578  46.970 44.791  1.00 49.65  ? 993  GLU C N   1 
ATOM   4987 C CA  . GLU C 1 143 ? -34.959  46.791 46.124  1.00 56.64  ? 993  GLU C CA  1 
ATOM   4988 C C   . GLU C 1 143 ? -36.034  46.479 47.158  1.00 52.00  ? 993  GLU C C   1 
ATOM   4989 O O   . GLU C 1 143 ? -35.904  45.481 47.854  1.00 52.73  ? 993  GLU C O   1 
ATOM   4990 C CB  . GLU C 1 143 ? -34.266  48.079 46.551  1.00 52.28  ? 993  GLU C CB  1 
ATOM   4991 C CG  . GLU C 1 143 ? -32.962  48.315 45.824  1.00 70.98  ? 993  GLU C CG  1 
ATOM   4992 C CD  . GLU C 1 143 ? -31.931  47.242 46.120  1.00 71.65  ? 993  GLU C CD  1 
ATOM   4993 O OE1 . GLU C 1 143 ? -31.495  47.161 47.279  1.00 73.08  ? 993  GLU C OE1 1 
ATOM   4994 O OE2 . GLU C 1 143 ? -31.602  46.471 45.201  1.00 71.64  ? 993  GLU C OE2 1 
ATOM   4995 N N   . LEU C 1 144 ? -37.061  47.318 47.210  1.00 53.49  ? 994  LEU C N   1 
ATOM   4996 C CA  . LEU C 1 144 ? -38.129  47.143 48.220  1.00 47.89  ? 994  LEU C CA  1 
ATOM   4997 C C   . LEU C 1 144 ? -38.783  45.780 47.999  1.00 50.41  ? 994  LEU C C   1 
ATOM   4998 O O   . LEU C 1 144 ? -39.079  45.096 48.968  1.00 50.81  ? 994  LEU C O   1 
ATOM   4999 C CB  . LEU C 1 144 ? -39.094  48.322 48.083  1.00 43.67  ? 994  LEU C CB  1 
ATOM   5000 C CG  . LEU C 1 144 ? -38.628  49.629 48.714  1.00 46.71  ? 994  LEU C CG  1 
ATOM   5001 C CD1 . LEU C 1 144 ? -39.571  50.765 48.364  1.00 45.70  ? 994  LEU C CD1 1 
ATOM   5002 C CD2 . LEU C 1 144 ? -38.515  49.477 50.219  1.00 45.52  ? 994  LEU C CD2 1 
ATOM   5003 N N   . ARG C 1 145 ? -38.943  45.397 46.742  1.00 51.82  ? 995  ARG C N   1 
ATOM   5004 C CA  . ARG C 1 145 ? -39.591  44.108 46.431  1.00 51.95  ? 995  ARG C CA  1 
ATOM   5005 C C   . ARG C 1 145 ? -38.727  42.967 46.971  1.00 56.30  ? 995  ARG C C   1 
ATOM   5006 O O   . ARG C 1 145 ? -39.278  41.977 47.445  1.00 55.92  ? 995  ARG C O   1 
ATOM   5007 C CB  . ARG C 1 145 ? -39.805  44.022 44.920  1.00 53.69  ? 995  ARG C CB  1 
ATOM   5008 C CG  . ARG C 1 145 ? -40.845  43.010 44.471  1.00 59.51  ? 995  ARG C CG  1 
ATOM   5009 C CD  . ARG C 1 145 ? -41.480  43.400 43.147  1.00 60.34  ? 995  ARG C CD  1 
ATOM   5010 N NE  . ARG C 1 145 ? -40.520  43.612 42.072  1.00 66.36  ? 995  ARG C NE  1 
ATOM   5011 C CZ  . ARG C 1 145 ? -40.425  44.720 41.347  1.00 65.31  ? 995  ARG C CZ  1 
ATOM   5012 N NH1 . ARG C 1 145 ? -41.399  45.610 41.363  1.00 63.27  ? 995  ARG C NH1 1 
ATOM   5013 N NH2 . ARG C 1 145 ? -39.363  44.927 40.589  1.00 65.71  ? 995  ARG C NH2 1 
ATOM   5014 N N   . LEU C 1 146 ? -37.413  43.108 46.864  1.00 57.07  ? 996  LEU C N   1 
ATOM   5015 C CA  . LEU C 1 146 ? -36.506  42.026 47.309  1.00 58.97  ? 996  LEU C CA  1 
ATOM   5016 C C   . LEU C 1 146 ? -36.649  41.883 48.817  1.00 61.61  ? 996  LEU C C   1 
ATOM   5017 O O   . LEU C 1 146 ? -36.460  40.773 49.320  1.00 61.98  ? 996  LEU C O   1 
ATOM   5018 C CB  . LEU C 1 146 ? -35.077  42.402 46.927  1.00 61.40  ? 996  LEU C CB  1 
ATOM   5019 C CG  . LEU C 1 146 ? -34.753  42.343 45.438  1.00 64.19  ? 996  LEU C CG  1 
ATOM   5020 C CD1 . LEU C 1 146 ? -33.372  42.918 45.168  1.00 62.68  ? 996  LEU C CD1 1 
ATOM   5021 C CD2 . LEU C 1 146 ? -34.843  40.915 44.928  1.00 63.69  ? 996  LEU C CD2 1 
ATOM   5022 N N   . ARG C 1 147 ? -37.011  42.974 49.485  1.00 57.81  ? 997  ARG C N   1 
ATOM   5023 C CA  . ARG C 1 147 ? -37.136  42.952 50.958  1.00 53.27  ? 997  ARG C CA  1 
ATOM   5024 C C   . ARG C 1 147 ? -38.570  42.588 51.353  1.00 57.56  ? 997  ARG C C   1 
ATOM   5025 O O   . ARG C 1 147 ? -38.861  42.614 52.549  1.00 64.73  ? 997  ARG C O   1 
ATOM   5026 C CB  . ARG C 1 147 ? -36.627  44.292 51.490  1.00 58.19  ? 997  ARG C CB  1 
ATOM   5027 C CG  . ARG C 1 147 ? -35.225  44.645 51.022  1.00 58.44  ? 997  ARG C CG  1 
ATOM   5028 C CD  . ARG C 1 147 ? -34.893  46.111 51.185  1.00 59.84  ? 997  ARG C CD  1 
ATOM   5029 N NE  . ARG C 1 147 ? -35.160  46.599 52.525  1.00 59.26  ? 997  ARG C NE  1 
ATOM   5030 C CZ  . ARG C 1 147 ? -34.864  47.823 52.935  1.00 61.09  ? 997  ARG C CZ  1 
ATOM   5031 N NH1 . ARG C 1 147 ? -34.200  48.640 52.140  1.00 59.83  ? 997  ARG C NH1 1 
ATOM   5032 N NH2 . ARG C 1 147 ? -35.226  48.222 54.140  1.00 64.08  ? 997  ARG C NH2 1 
ATOM   5033 N N   . GLY C 1 148 ? -39.438  42.278 50.396  1.00 52.38  ? 998  GLY C N   1 
ATOM   5034 C CA  . GLY C 1 148 ? -40.794  41.820 50.745  1.00 57.92  ? 998  GLY C CA  1 
ATOM   5035 C C   . GLY C 1 148 ? -41.887  42.849 50.533  1.00 59.84  ? 998  GLY C C   1 
ATOM   5036 O O   . GLY C 1 148 ? -43.049  42.528 50.788  1.00 60.46  ? 998  GLY C O   1 
ATOM   5037 N N   . TYR C 1 149 ? -41.536  44.028 50.043  1.00 54.59  ? 999  TYR C N   1 
ATOM   5038 C CA  . TYR C 1 149 ? -42.523  45.089 49.868  1.00 51.66  ? 999  TYR C CA  1 
ATOM   5039 C C   . TYR C 1 149 ? -42.914  45.157 48.396  1.00 52.35  ? 999  TYR C C   1 
ATOM   5040 O O   . TYR C 1 149 ? -42.128  45.634 47.569  1.00 51.51  ? 999  TYR C O   1 
ATOM   5041 C CB  . TYR C 1 149 ? -41.962  46.435 50.328  1.00 48.19  ? 999  TYR C CB  1 
ATOM   5042 C CG  . TYR C 1 149 ? -41.515  46.507 51.772  1.00 53.90  ? 999  TYR C CG  1 
ATOM   5043 C CD1 . TYR C 1 149 ? -40.303  45.963 52.183  1.00 51.26  ? 999  TYR C CD1 1 
ATOM   5044 C CD2 . TYR C 1 149 ? -42.306  47.136 52.724  1.00 50.89  ? 999  TYR C CD2 1 
ATOM   5045 C CE1 . TYR C 1 149 ? -39.898  46.039 53.506  1.00 54.87  ? 999  TYR C CE1 1 
ATOM   5046 C CE2 . TYR C 1 149 ? -41.911  47.216 54.044  1.00 52.81  ? 999  TYR C CE2 1 
ATOM   5047 C CZ  . TYR C 1 149 ? -40.707  46.667 54.431  1.00 54.48  ? 999  TYR C CZ  1 
ATOM   5048 O OH  . TYR C 1 149 ? -40.315  46.745 55.747  1.00 51.56  ? 999  TYR C OH  1 
ATOM   5049 N N   . ASP C 1 150 ? -44.126  44.679 48.056  1.00 52.01  ? 1000 ASP C N   1 
ATOM   5050 C CA  . ASP C 1 150 ? -44.573  44.642 46.667  1.00 49.94  ? 1000 ASP C CA  1 
ATOM   5051 C C   . ASP C 1 150 ? -45.609  45.753 46.481  1.00 50.93  ? 1000 ASP C C   1 
ATOM   5052 O O   . ASP C 1 150 ? -46.779  45.627 46.881  1.00 54.11  ? 1000 ASP C O   1 
ATOM   5053 C CB  . ASP C 1 150 ? -45.134  43.272 46.304  1.00 56.76  ? 1000 ASP C CB  1 
ATOM   5054 C CG  . ASP C 1 150 ? -45.238  43.063 44.805  1.00 65.77  ? 1000 ASP C CG  1 
ATOM   5055 O OD1 . ASP C 1 150 ? -44.997  44.025 44.043  1.00 58.51  ? 1000 ASP C OD1 1 
ATOM   5056 O OD2 . ASP C 1 150 ? -45.578  41.937 44.388  1.00 69.84  ? 1000 ASP C OD2 1 
ATOM   5057 N N   . TYR C 1 151 ? -45.181  46.831 45.838  1.00 45.23  ? 1001 TYR C N   1 
ATOM   5058 C CA  . TYR C 1 151 ? -46.038  47.973 45.576  1.00 40.67  ? 1001 TYR C CA  1 
ATOM   5059 C C   . TYR C 1 151 ? -46.399  47.986 44.098  1.00 48.21  ? 1001 TYR C C   1 
ATOM   5060 O O   . TYR C 1 151 ? -45.522  47.842 43.239  1.00 48.23  ? 1001 TYR C O   1 
ATOM   5061 C CB  . TYR C 1 151 ? -45.361  49.284 45.988  1.00 41.75  ? 1001 TYR C CB  1 
ATOM   5062 C CG  . TYR C 1 151 ? -45.053  49.355 47.469  1.00 45.51  ? 1001 TYR C CG  1 
ATOM   5063 C CD1 . TYR C 1 151 ? -46.072  49.491 48.405  1.00 41.59  ? 1001 TYR C CD1 1 
ATOM   5064 C CD2 . TYR C 1 151 ? -43.746  49.285 47.931  1.00 38.60  ? 1001 TYR C CD2 1 
ATOM   5065 C CE1 . TYR C 1 151 ? -45.796  49.552 49.762  1.00 41.60  ? 1001 TYR C CE1 1 
ATOM   5066 C CE2 . TYR C 1 151 ? -43.461  49.348 49.284  1.00 41.50  ? 1001 TYR C CE2 1 
ATOM   5067 C CZ  . TYR C 1 151 ? -44.488  49.480 50.195  1.00 41.44  ? 1001 TYR C CZ  1 
ATOM   5068 O OH  . TYR C 1 151 ? -44.207  49.542 51.542  1.00 39.36  ? 1001 TYR C OH  1 
ATOM   5069 N N   . GLY C 1 152 ? -47.702  48.048 43.817  1.00 46.92  ? 1002 GLY C N   1 
ATOM   5070 C CA  . GLY C 1 152 ? -48.186  48.274 42.476  1.00 40.73  ? 1002 GLY C CA  1 
ATOM   5071 C C   . GLY C 1 152 ? -48.191  49.746 42.116  1.00 35.67  ? 1002 GLY C C   1 
ATOM   5072 O O   . GLY C 1 152 ? -47.848  50.620 42.923  1.00 38.57  ? 1002 GLY C O   1 
ATOM   5073 N N   . PRO C 1 153 ? -48.613  50.038 40.878  1.00 43.64  ? 1003 PRO C N   1 
ATOM   5074 C CA  . PRO C 1 153 ? -48.465  51.410 40.347  1.00 39.49  ? 1003 PRO C CA  1 
ATOM   5075 C C   . PRO C 1 153 ? -49.020  52.522 41.228  1.00 37.70  ? 1003 PRO C C   1 
ATOM   5076 O O   . PRO C 1 153 ? -48.396  53.586 41.318  1.00 39.76  ? 1003 PRO C O   1 
ATOM   5077 C CB  . PRO C 1 153 ? -49.216  51.349 39.009  1.00 43.46  ? 1003 PRO C CB  1 
ATOM   5078 C CG  . PRO C 1 153 ? -49.212  49.920 38.611  1.00 40.59  ? 1003 PRO C CG  1 
ATOM   5079 C CD  . PRO C 1 153 ? -48.973  49.067 39.829  1.00 42.48  ? 1003 PRO C CD  1 
ATOM   5080 N N   . HIS C 1 154 ? -50.176  52.325 41.869  1.00 41.12  ? 1004 HIS C N   1 
ATOM   5081 C CA  . HIS C 1 154 ? -50.758  53.406 42.659  1.00 38.97  ? 1004 HIS C CA  1 
ATOM   5082 C C   . HIS C 1 154 ? -49.930  53.735 43.892  1.00 36.41  ? 1004 HIS C C   1 
ATOM   5083 O O   . HIS C 1 154 ? -50.091  54.822 44.458  1.00 39.12  ? 1004 HIS C O   1 
ATOM   5084 C CB  . HIS C 1 154 ? -52.186  53.060 43.080  1.00 37.38  ? 1004 HIS C CB  1 
ATOM   5085 C CG  . HIS C 1 154 ? -53.171  53.087 41.955  1.00 37.45  ? 1004 HIS C CG  1 
ATOM   5086 N ND1 . HIS C 1 154 ? -53.572  54.255 41.341  1.00 47.69  ? 1004 HIS C ND1 1 
ATOM   5087 C CD2 . HIS C 1 154 ? -53.843  52.088 41.337  1.00 41.56  ? 1004 HIS C CD2 1 
ATOM   5088 C CE1 . HIS C 1 154 ? -54.444  53.973 40.390  1.00 45.46  ? 1004 HIS C CE1 1 
ATOM   5089 N NE2 . HIS C 1 154 ? -54.627  52.665 40.368  1.00 45.88  ? 1004 HIS C NE2 1 
ATOM   5090 N N   . PHE C 1 155 ? -49.060  52.827 44.331  1.00 36.85  ? 1005 PHE C N   1 
ATOM   5091 C CA  . PHE C 1 155 ? -48.204  53.083 45.480  1.00 37.76  ? 1005 PHE C CA  1 
ATOM   5092 C C   . PHE C 1 155 ? -46.738  53.243 45.101  1.00 41.54  ? 1005 PHE C C   1 
ATOM   5093 O O   . PHE C 1 155 ? -45.885  53.319 45.991  1.00 37.66  ? 1005 PHE C O   1 
ATOM   5094 C CB  . PHE C 1 155 ? -48.370  51.976 46.522  1.00 37.69  ? 1005 PHE C CB  1 
ATOM   5095 C CG  . PHE C 1 155 ? -49.581  52.153 47.386  1.00 36.26  ? 1005 PHE C CG  1 
ATOM   5096 C CD1 . PHE C 1 155 ? -50.832  51.765 46.938  1.00 36.87  ? 1005 PHE C CD1 1 
ATOM   5097 C CD2 . PHE C 1 155 ? -49.476  52.761 48.626  1.00 34.93  ? 1005 PHE C CD2 1 
ATOM   5098 C CE1 . PHE C 1 155 ? -51.953  51.946 47.727  1.00 33.49  ? 1005 PHE C CE1 1 
ATOM   5099 C CE2 . PHE C 1 155 ? -50.593  52.948 49.418  1.00 35.93  ? 1005 PHE C CE2 1 
ATOM   5100 C CZ  . PHE C 1 155 ? -51.833  52.539 48.968  1.00 36.28  ? 1005 PHE C CZ  1 
ATOM   5101 N N   . GLN C 1 156 ? -46.423  53.316 43.808  1.00 39.62  ? 1006 GLN C N   1 
ATOM   5102 C CA  . GLN C 1 156 ? -45.051  53.570 43.368  1.00 40.87  ? 1006 GLN C CA  1 
ATOM   5103 C C   . GLN C 1 156 ? -44.861  55.070 43.147  1.00 42.37  ? 1006 GLN C C   1 
ATOM   5104 O O   . GLN C 1 156 ? -44.677  55.561 42.031  1.00 43.78  ? 1006 GLN C O   1 
ATOM   5105 C CB  . GLN C 1 156 ? -44.733  52.770 42.114  1.00 35.13  ? 1006 GLN C CB  1 
ATOM   5106 C CG  . GLN C 1 156 ? -44.554  51.287 42.353  1.00 39.77  ? 1006 GLN C CG  1 
ATOM   5107 C CD  . GLN C 1 156 ? -44.381  50.529 41.060  1.00 45.91  ? 1006 GLN C CD  1 
ATOM   5108 O OE1 . GLN C 1 156 ? -44.061  51.117 40.027  1.00 48.91  ? 1006 GLN C OE1 1 
ATOM   5109 N NE2 . GLN C 1 156 ? -44.585  49.219 41.105  1.00 45.15  ? 1006 GLN C NE2 1 
ATOM   5110 N N   . GLY C 1 157 ? -44.899  55.798 44.260  1.00 35.58  ? 1007 GLY C N   1 
ATOM   5111 C CA  . GLY C 1 157 ? -44.796  57.243 44.242  1.00 33.55  ? 1007 GLY C CA  1 
ATOM   5112 C C   . GLY C 1 157 ? -43.401  57.785 44.462  1.00 38.44  ? 1007 GLY C C   1 
ATOM   5113 O O   . GLY C 1 157 ? -43.176  58.990 44.311  1.00 39.70  ? 1007 GLY C O   1 
ATOM   5114 N N   . ILE C 1 158 ? -42.457  56.929 44.844  1.00 38.11  ? 1008 ILE C N   1 
ATOM   5115 C CA  . ILE C 1 158 ? -41.066  57.354 44.924  1.00 40.64  ? 1008 ILE C CA  1 
ATOM   5116 C C   . ILE C 1 158 ? -40.571  57.425 43.482  1.00 38.69  ? 1008 ILE C C   1 
ATOM   5117 O O   . ILE C 1 158 ? -40.421  56.397 42.818  1.00 40.97  ? 1008 ILE C O   1 
ATOM   5118 C CB  . ILE C 1 158 ? -40.224  56.387 45.767  1.00 39.67  ? 1008 ILE C CB  1 
ATOM   5119 C CG1 . ILE C 1 158 ? -40.645  56.445 47.239  1.00 35.11  ? 1008 ILE C CG1 1 
ATOM   5120 C CG2 . ILE C 1 158 ? -38.747  56.726 45.660  1.00 41.00  ? 1008 ILE C CG2 1 
ATOM   5121 C CD1 . ILE C 1 158 ? -40.046  55.345 48.093  1.00 38.09  ? 1008 ILE C CD1 1 
ATOM   5122 N N   . LEU C 1 159 ? -40.263  58.633 43.011  1.00 37.96  ? 1009 LEU C N   1 
ATOM   5123 C CA  . LEU C 1 159 ? -39.744  58.777 41.657  1.00 44.31  ? 1009 LEU C CA  1 
ATOM   5124 C C   . LEU C 1 159 ? -38.231  58.618 41.641  1.00 47.32  ? 1009 LEU C C   1 
ATOM   5125 O O   . LEU C 1 159 ? -37.678  58.068 40.684  1.00 51.76  ? 1009 LEU C O   1 
ATOM   5126 C CB  . LEU C 1 159 ? -40.185  60.113 41.056  1.00 45.51  ? 1009 LEU C CB  1 
ATOM   5127 C CG  . LEU C 1 159 ? -41.695  60.342 41.159  1.00 47.11  ? 1009 LEU C CG  1 
ATOM   5128 C CD1 . LEU C 1 159 ? -42.035  61.754 40.776  1.00 49.06  ? 1009 LEU C CD1 1 
ATOM   5129 C CD2 . LEU C 1 159 ? -42.457  59.351 40.285  1.00 46.97  ? 1009 LEU C CD2 1 
ATOM   5130 N N   . GLU C 1 160 ? -37.546  59.110 42.670  1.00 44.46  ? 1010 GLU C N   1 
ATOM   5131 C CA  . GLU C 1 160 ? -36.100  58.966 42.776  1.00 50.75  ? 1010 GLU C CA  1 
ATOM   5132 C C   . GLU C 1 160 ? -35.738  59.049 44.251  1.00 48.01  ? 1010 GLU C C   1 
ATOM   5133 O O   . GLU C 1 160 ? -36.454  59.668 45.042  1.00 46.55  ? 1010 GLU C O   1 
ATOM   5134 C CB  . GLU C 1 160 ? -35.305  59.997 41.969  1.00 54.52  ? 1010 GLU C CB  1 
ATOM   5135 C CG  . GLU C 1 160 ? -35.075  61.311 42.667  1.00 56.30  ? 1010 GLU C CG  1 
ATOM   5136 C CD  . GLU C 1 160 ? -34.411  62.326 41.764  1.00 66.22  ? 1010 GLU C CD  1 
ATOM   5137 O OE1 . GLU C 1 160 ? -34.213  62.022 40.568  1.00 67.82  ? 1010 GLU C OE1 1 
ATOM   5138 O OE2 . GLU C 1 160 ? -34.074  63.421 42.256  1.00 70.56  ? 1010 GLU C OE2 1 
ATOM   5139 N N   . ALA C 1 161 ? -34.664  58.357 44.626  1.00 45.94  ? 1011 ALA C N   1 
ATOM   5140 C CA  . ALA C 1 161 ? -34.184  58.385 45.999  1.00 42.14  ? 1011 ALA C CA  1 
ATOM   5141 C C   . ALA C 1 161 ? -32.663  58.405 46.028  1.00 49.16  ? 1011 ALA C C   1 
ATOM   5142 O O   . ALA C 1 161 ? -32.004  57.762 45.206  1.00 51.41  ? 1011 ALA C O   1 
ATOM   5143 C CB  . ALA C 1 161 ? -34.706  57.176 46.782  1.00 43.61  ? 1011 ALA C CB  1 
ATOM   5144 N N   . SER C 1 162 ? -32.113  59.111 47.018  1.00 44.86  ? 1012 SER C N   1 
ATOM   5145 C CA  . SER C 1 162 ? -30.670  59.135 47.214  1.00 49.84  ? 1012 SER C CA  1 
ATOM   5146 C C   . SER C 1 162 ? -30.156  57.724 47.493  1.00 53.53  ? 1012 SER C C   1 
ATOM   5147 O O   . SER C 1 162 ? -30.906  56.826 47.884  1.00 50.19  ? 1012 SER C O   1 
ATOM   5148 C CB  . SER C 1 162 ? -30.298  60.093 48.349  1.00 49.37  ? 1012 SER C CB  1 
ATOM   5149 O OG  . SER C 1 162 ? -30.602  59.540 49.617  1.00 48.24  ? 1012 SER C OG  1 
ATOM   5150 N N   . LEU C 1 163 ? -28.850  57.539 47.288  1.00 48.42  ? 1013 LEU C N   1 
ATOM   5151 C CA  . LEU C 1 163 ? -28.251  56.212 47.418  1.00 52.45  ? 1013 LEU C CA  1 
ATOM   5152 C C   . LEU C 1 163 ? -28.466  55.633 48.815  1.00 49.02  ? 1013 LEU C C   1 
ATOM   5153 O O   . LEU C 1 163 ? -28.708  54.430 48.964  1.00 50.51  ? 1013 LEU C O   1 
ATOM   5154 C CB  . LEU C 1 163 ? -26.765  56.265 47.047  1.00 54.61  ? 1013 LEU C CB  1 
ATOM   5155 C CG  . LEU C 1 163 ? -26.265  55.226 46.028  1.00 60.60  ? 1013 LEU C CG  1 
ATOM   5156 C CD1 . LEU C 1 163 ? -27.081  55.296 44.736  1.00 54.87  ? 1013 LEU C CD1 1 
ATOM   5157 C CD2 . LEU C 1 163 ? -24.781  55.403 45.724  1.00 51.54  ? 1013 LEU C CD2 1 
ATOM   5158 N N   . GLU C 1 164 ? -28.309  56.452 49.853  1.00 48.08  ? 1014 GLU C N   1 
ATOM   5159 C CA  . GLU C 1 164 ? -28.515  56.009 51.227  1.00 50.45  ? 1014 GLU C CA  1 
ATOM   5160 C C   . GLU C 1 164 ? -29.957  56.156 51.709  1.00 55.19  ? 1014 GLU C C   1 
ATOM   5161 O O   . GLU C 1 164 ? -30.272  55.695 52.811  1.00 53.14  ? 1014 GLU C O   1 
ATOM   5162 C CB  . GLU C 1 164 ? -27.595  56.793 52.165  1.00 53.92  ? 1014 GLU C CB  1 
ATOM   5163 C CG  . GLU C 1 164 ? -26.113  56.546 51.934  1.00 53.11  ? 1014 GLU C CG  1 
ATOM   5164 C CD  . GLU C 1 164 ? -25.609  55.289 52.610  1.00 63.47  ? 1014 GLU C CD  1 
ATOM   5165 O OE1 . GLU C 1 164 ? -26.306  54.767 53.502  1.00 61.25  ? 1014 GLU C OE1 1 
ATOM   5166 O OE2 . GLU C 1 164 ? -24.513  54.818 52.248  1.00 60.99  ? 1014 GLU C OE2 1 
ATOM   5167 N N   . GLY C 1 165 ? -30.849  56.712 50.892  1.00 50.10  ? 1015 GLY C N   1 
ATOM   5168 C CA  . GLY C 1 165 ? -32.255  56.783 51.244  1.00 48.73  ? 1015 GLY C CA  1 
ATOM   5169 C C   . GLY C 1 165 ? -32.640  57.889 52.204  1.00 49.66  ? 1015 GLY C C   1 
ATOM   5170 O O   . GLY C 1 165 ? -33.669  57.776 52.878  1.00 48.56  ? 1015 GLY C O   1 
ATOM   5171 N N   . ASP C 1 166 ? -31.868  58.975 52.267  1.00 44.99  ? 1016 ASP C N   1 
ATOM   5172 C CA  . ASP C 1 166 ? -32.166  60.083 53.167  1.00 44.99  ? 1016 ASP C CA  1 
ATOM   5173 C C   . ASP C 1 166 ? -32.840  61.244 52.451  1.00 42.57  ? 1016 ASP C C   1 
ATOM   5174 O O   . ASP C 1 166 ? -33.152  62.254 53.089  1.00 45.29  ? 1016 ASP C O   1 
ATOM   5175 C CB  . ASP C 1 166 ? -30.897  60.591 53.867  1.00 49.12  ? 1016 ASP C CB  1 
ATOM   5176 C CG  . ASP C 1 166 ? -29.664  60.520 52.986  1.00 55.93  ? 1016 ASP C CG  1 
ATOM   5177 O OD1 . ASP C 1 166 ? -29.807  60.502 51.746  1.00 51.17  ? 1016 ASP C OD1 1 
ATOM   5178 O OD2 . ASP C 1 166 ? -28.544  60.508 53.541  1.00 67.74  ? 1016 ASP C OD2 1 
ATOM   5179 N N   . SER C 1 167 ? -33.036  61.142 51.140  1.00 47.13  ? 1017 SER C N   1 
ATOM   5180 C CA  . SER C 1 167 ? -33.732  62.177 50.392  1.00 41.87  ? 1017 SER C CA  1 
ATOM   5181 C C   . SER C 1 167 ? -34.323  61.564 49.133  1.00 37.52  ? 1017 SER C C   1 
ATOM   5182 O O   . SER C 1 167 ? -33.948  60.463 48.720  1.00 40.65  ? 1017 SER C O   1 
ATOM   5183 C CB  . SER C 1 167 ? -32.797  63.338 50.043  1.00 48.23  ? 1017 SER C CB  1 
ATOM   5184 O OG  . SER C 1 167 ? -31.768  62.902 49.175  1.00 43.50  ? 1017 SER C OG  1 
ATOM   5185 N N   . GLY C 1 168 ? -35.272  62.280 48.545  1.00 38.26  ? 1018 GLY C N   1 
ATOM   5186 C CA  . GLY C 1 168 ? -35.869  61.796 47.316  1.00 34.42  ? 1018 GLY C CA  1 
ATOM   5187 C C   . GLY C 1 168 ? -36.973  62.707 46.830  1.00 33.48  ? 1018 GLY C C   1 
ATOM   5188 O O   . GLY C 1 168 ? -37.169  63.811 47.343  1.00 36.78  ? 1018 GLY C O   1 
ATOM   5189 N N   . ARG C 1 169 ? -37.768  62.173 45.907  1.00 38.06  ? 1019 ARG C N   1 
ATOM   5190 C CA  . ARG C 1 169 ? -38.838  62.913 45.251  1.00 43.49  ? 1019 ARG C CA  1 
ATOM   5191 C C   . ARG C 1 169 ? -40.081  62.045 45.180  1.00 34.21  ? 1019 ARG C C   1 
ATOM   5192 O O   . ARG C 1 169 ? -40.013  60.901 44.726  1.00 39.39  ? 1019 ARG C O   1 
ATOM   5193 C CB  . ARG C 1 169 ? -38.447  63.362 43.840  1.00 40.98  ? 1019 ARG C CB  1 
ATOM   5194 C CG  . ARG C 1 169 ? -39.183  64.608 43.396  1.00 47.19  ? 1019 ARG C CG  1 
ATOM   5195 C CD  . ARG C 1 169 ? -38.870  64.956 41.959  1.00 59.35  ? 1019 ARG C CD  1 
ATOM   5196 N NE  . ARG C 1 169 ? -37.991  66.113 41.880  1.00 54.44  ? 1019 ARG C NE  1 
ATOM   5197 C CZ  . ARG C 1 169 ? -37.122  66.329 40.903  1.00 59.72  ? 1019 ARG C CZ  1 
ATOM   5198 N NH1 . ARG C 1 169 ? -36.974  65.470 39.907  1.00 58.96  ? 1019 ARG C NH1 1 
ATOM   5199 N NH2 . ARG C 1 169 ? -36.376  67.429 40.930  1.00 61.35  ? 1019 ARG C NH2 1 
ATOM   5200 N N   . LEU C 1 170 ? -41.196  62.562 45.686  1.00 38.95  ? 1020 LEU C N   1 
ATOM   5201 C CA  . LEU C 1 170 ? -42.437  61.814 45.803  1.00 40.08  ? 1020 LEU C CA  1 
ATOM   5202 C C   . LEU C 1 170 ? -43.490  62.405 44.875  1.00 30.38  ? 1020 LEU C C   1 
ATOM   5203 O O   . LEU C 1 170 ? -43.712  63.620 44.868  1.00 37.13  ? 1020 LEU C O   1 
ATOM   5204 C CB  . LEU C 1 170 ? -42.950  61.824 47.247  1.00 34.22  ? 1020 LEU C CB  1 
ATOM   5205 C CG  . LEU C 1 170 ? -42.006  61.253 48.308  1.00 35.39  ? 1020 LEU C CG  1 
ATOM   5206 C CD1 . LEU C 1 170 ? -42.647  61.286 49.692  1.00 36.61  ? 1020 LEU C CD1 1 
ATOM   5207 C CD2 . LEU C 1 170 ? -41.576  59.843 47.941  1.00 33.69  ? 1020 LEU C CD2 1 
ATOM   5208 N N   . LEU C 1 171 ? -44.186  61.525 44.160  1.00 36.68  ? 1021 LEU C N   1 
ATOM   5209 C CA  . LEU C 1 171 ? -45.297  61.924 43.309  1.00 38.91  ? 1021 LEU C CA  1 
ATOM   5210 C C   . LEU C 1 171 ? -46.491  62.317 44.168  1.00 44.55  ? 1021 LEU C C   1 
ATOM   5211 O O   . LEU C 1 171 ? -46.720  61.743 45.235  1.00 39.13  ? 1021 LEU C O   1 
ATOM   5212 C CB  . LEU C 1 171 ? -45.675  60.757 42.396  1.00 42.08  ? 1021 LEU C CB  1 
ATOM   5213 C CG  . LEU C 1 171 ? -46.666  60.955 41.253  1.00 49.25  ? 1021 LEU C CG  1 
ATOM   5214 C CD1 . LEU C 1 171 ? -46.132  61.918 40.214  1.00 47.84  ? 1021 LEU C CD1 1 
ATOM   5215 C CD2 . LEU C 1 171 ? -47.014  59.604 40.632  1.00 48.60  ? 1021 LEU C CD2 1 
ATOM   5216 N N   . TRP C 1 172 ? -47.251  63.309 43.702  1.00 40.92  ? 1022 TRP C N   1 
ATOM   5217 C CA  . TRP C 1 172 ? -48.505  63.719 44.325  1.00 38.22  ? 1022 TRP C CA  1 
ATOM   5218 C C   . TRP C 1 172 ? -49.660  63.530 43.352  1.00 47.29  ? 1022 TRP C C   1 
ATOM   5219 O O   . TRP C 1 172 ? -49.611  64.026 42.221  1.00 42.06  ? 1022 TRP C O   1 
ATOM   5220 C CB  . TRP C 1 172 ? -48.431  65.176 44.782  1.00 37.74  ? 1022 TRP C CB  1 
ATOM   5221 C CG  . TRP C 1 172 ? -49.722  65.724 45.313  1.00 39.66  ? 1022 TRP C CG  1 
ATOM   5222 C CD1 . TRP C 1 172 ? -50.483  66.706 44.754  1.00 42.23  ? 1022 TRP C CD1 1 
ATOM   5223 C CD2 . TRP C 1 172 ? -50.388  65.341 46.525  1.00 39.15  ? 1022 TRP C CD2 1 
ATOM   5224 N NE1 . TRP C 1 172 ? -51.587  66.953 45.533  1.00 40.91  ? 1022 TRP C NE1 1 
ATOM   5225 C CE2 . TRP C 1 172 ? -51.553  66.128 46.626  1.00 40.51  ? 1022 TRP C CE2 1 
ATOM   5226 C CE3 . TRP C 1 172 ? -50.117  64.405 47.529  1.00 35.94  ? 1022 TRP C CE3 1 
ATOM   5227 C CZ2 . TRP C 1 172 ? -52.444  66.010 47.692  1.00 39.53  ? 1022 TRP C CZ2 1 
ATOM   5228 C CZ3 . TRP C 1 172 ? -51.005  64.289 48.586  1.00 35.38  ? 1022 TRP C CZ3 1 
ATOM   5229 C CH2 . TRP C 1 172 ? -52.154  65.086 48.658  1.00 37.28  ? 1022 TRP C CH2 1 
ATOM   5230 N N   . LYS C 1 173 ? -50.681  62.784 43.780  1.00 38.55  ? 1023 LYS C N   1 
ATOM   5231 C CA  . LYS C 1 173 ? -51.834  62.494 42.937  1.00 41.62  ? 1023 LYS C CA  1 
ATOM   5232 C C   . LYS C 1 173 ? -53.142  62.818 43.659  1.00 41.13  ? 1023 LYS C C   1 
ATOM   5233 O O   . LYS C 1 173 ? -54.164  62.166 43.422  1.00 43.42  ? 1023 LYS C O   1 
ATOM   5234 C CB  . LYS C 1 173 ? -51.799  61.024 42.521  1.00 46.66  ? 1023 LYS C CB  1 
ATOM   5235 C CG  . LYS C 1 173 ? -50.703  60.701 41.512  1.00 55.25  ? 1023 LYS C CG  1 
ATOM   5236 C CD  . LYS C 1 173 ? -51.142  60.852 40.073  1.00 56.63  ? 1023 LYS C CD  1 
ATOM   5237 C CE  . LYS C 1 173 ? -51.529  59.504 39.486  1.00 61.95  ? 1023 LYS C CE  1 
ATOM   5238 N NZ  . LYS C 1 173 ? -51.206  59.433 38.035  1.00 64.68  ? 1023 LYS C NZ  1 
ATOM   5239 N N   . ASP C 1 174 ? -53.132  63.841 44.519  1.00 38.06  ? 1024 ASP C N   1 
ATOM   5240 C CA  . ASP C 1 174 ? -54.272  64.171 45.385  1.00 41.05  ? 1024 ASP C CA  1 
ATOM   5241 C C   . ASP C 1 174 ? -54.777  62.937 46.128  1.00 41.92  ? 1024 ASP C C   1 
ATOM   5242 O O   . ASP C 1 174 ? -55.979  62.748 46.329  1.00 40.16  ? 1024 ASP C O   1 
ATOM   5243 C CB  . ASP C 1 174 ? -55.406  64.860 44.625  1.00 42.01  ? 1024 ASP C CB  1 
ATOM   5244 C CG  . ASP C 1 174 ? -55.074  66.293 44.265  1.00 47.91  ? 1024 ASP C CG  1 
ATOM   5245 O OD1 . ASP C 1 174 ? -54.944  67.123 45.191  1.00 51.40  ? 1024 ASP C OD1 1 
ATOM   5246 O OD2 . ASP C 1 174 ? -54.972  66.601 43.064  1.00 57.48  ? 1024 ASP C OD2 1 
ATOM   5247 N N   . ASN C 1 175 ? -53.835  62.116 46.586  1.00 37.24  ? 1025 ASN C N   1 
ATOM   5248 C CA  . ASN C 1 175 ? -54.121  60.901 47.344  1.00 34.58  ? 1025 ASN C CA  1 
ATOM   5249 C C   . ASN C 1 175 ? -53.226  60.979 48.573  1.00 38.09  ? 1025 ASN C C   1 
ATOM   5250 O O   . ASN C 1 175 ? -52.020  60.731 48.485  1.00 33.58  ? 1025 ASN C O   1 
ATOM   5251 C CB  . ASN C 1 175 ? -53.836  59.631 46.545  1.00 34.31  ? 1025 ASN C CB  1 
ATOM   5252 C CG  . ASN C 1 175 ? -54.345  58.376 47.244  1.00 37.59  ? 1025 ASN C CG  1 
ATOM   5253 O OD1 . ASN C 1 175 ? -54.158  58.206 48.450  1.00 36.26  ? 1025 ASN C OD1 1 
ATOM   5254 N ND2 . ASN C 1 175 ? -54.951  57.474 46.481  1.00 38.05  ? 1025 ASN C ND2 1 
ATOM   5255 N N   . TRP C 1 176 ? -53.820  61.320 49.717  1.00 32.27  ? 1026 TRP C N   1 
ATOM   5256 C CA  . TRP C 1 176 ? -53.034  61.438 50.939  1.00 31.47  ? 1026 TRP C CA  1 
ATOM   5257 C C   . TRP C 1 176 ? -52.534  60.085 51.410  1.00 33.94  ? 1026 TRP C C   1 
ATOM   5258 O O   . TRP C 1 176 ? -51.458  59.994 52.016  1.00 33.57  ? 1026 TRP C O   1 
ATOM   5259 C CB  . TRP C 1 176 ? -53.859  62.077 52.051  1.00 31.09  ? 1026 TRP C CB  1 
ATOM   5260 C CG  . TRP C 1 176 ? -54.139  63.522 51.875  1.00 34.45  ? 1026 TRP C CG  1 
ATOM   5261 C CD1 . TRP C 1 176 ? -55.310  64.078 51.462  1.00 35.48  ? 1026 TRP C CD1 1 
ATOM   5262 C CD2 . TRP C 1 176 ? -53.240  64.610 52.123  1.00 35.75  ? 1026 TRP C CD2 1 
ATOM   5263 N NE1 . TRP C 1 176 ? -55.201  65.445 51.434  1.00 34.84  ? 1026 TRP C NE1 1 
ATOM   5264 C CE2 . TRP C 1 176 ? -53.939  65.798 51.834  1.00 36.77  ? 1026 TRP C CE2 1 
ATOM   5265 C CE3 . TRP C 1 176 ? -51.914  64.695 52.557  1.00 33.00  ? 1026 TRP C CE3 1 
ATOM   5266 C CZ2 . TRP C 1 176 ? -53.358  67.056 51.965  1.00 34.27  ? 1026 TRP C CZ2 1 
ATOM   5267 C CZ3 . TRP C 1 176 ? -51.338  65.947 52.687  1.00 35.63  ? 1026 TRP C CZ3 1 
ATOM   5268 C CH2 . TRP C 1 176 ? -52.060  67.110 52.391  1.00 36.76  ? 1026 TRP C CH2 1 
ATOM   5269 N N   . VAL C 1 177 ? -53.309  59.031 51.158  1.00 30.50  ? 1027 VAL C N   1 
ATOM   5270 C CA  . VAL C 1 177 ? -52.964  57.712 51.670  1.00 31.39  ? 1027 VAL C CA  1 
ATOM   5271 C C   . VAL C 1 177 ? -51.709  57.188 50.982  1.00 37.04  ? 1027 VAL C C   1 
ATOM   5272 O O   . VAL C 1 177 ? -50.754  56.756 51.639  1.00 31.30  ? 1027 VAL C O   1 
ATOM   5273 C CB  . VAL C 1 177 ? -54.153  56.751 51.500  1.00 29.03  ? 1027 VAL C CB  1 
ATOM   5274 C CG1 . VAL C 1 177 ? -53.735  55.319 51.810  1.00 27.42  ? 1027 VAL C CG1 1 
ATOM   5275 C CG2 . VAL C 1 177 ? -55.323  57.204 52.360  1.00 27.83  ? 1027 VAL C CG2 1 
ATOM   5276 N N   . SER C 1 178 ? -51.673  57.248 49.648  1.00 33.81  ? 1028 SER C N   1 
ATOM   5277 C CA  . SER C 1 178 ? -50.497  56.741 48.950  1.00 33.14  ? 1028 SER C CA  1 
ATOM   5278 C C   . SER C 1 178 ? -49.299  57.674 49.109  1.00 31.24  ? 1028 SER C C   1 
ATOM   5279 O O   . SER C 1 178 ? -48.162  57.199 49.216  1.00 35.08  ? 1028 SER C O   1 
ATOM   5280 C CB  . SER C 1 178 ? -50.811  56.498 47.472  1.00 34.43  ? 1028 SER C CB  1 
ATOM   5281 O OG  . SER C 1 178 ? -51.232  57.681 46.820  1.00 34.78  ? 1028 SER C OG  1 
ATOM   5282 N N   . PHE C 1 179 ? -49.522  58.992 49.152  1.00 33.94  ? 1029 PHE C N   1 
ATOM   5283 C CA  . PHE C 1 179 ? -48.413  59.914 49.395  1.00 35.20  ? 1029 PHE C CA  1 
ATOM   5284 C C   . PHE C 1 179 ? -47.743  59.617 50.733  1.00 35.27  ? 1029 PHE C C   1 
ATOM   5285 O O   . PHE C 1 179 ? -46.516  59.420 50.821  1.00 35.49  ? 1029 PHE C O   1 
ATOM   5286 C CB  . PHE C 1 179 ? -48.914  61.360 49.368  1.00 30.71  ? 1029 PHE C CB  1 
ATOM   5287 C CG  . PHE C 1 179 ? -47.822  62.376 49.546  1.00 36.78  ? 1029 PHE C CG  1 
ATOM   5288 C CD1 . PHE C 1 179 ? -47.009  62.724 48.483  1.00 35.90  ? 1029 PHE C CD1 1 
ATOM   5289 C CD2 . PHE C 1 179 ? -47.590  62.962 50.782  1.00 30.22  ? 1029 PHE C CD2 1 
ATOM   5290 C CE1 . PHE C 1 179 ? -45.994  63.647 48.640  1.00 32.54  ? 1029 PHE C CE1 1 
ATOM   5291 C CE2 . PHE C 1 179 ? -46.573  63.887 50.947  1.00 38.10  ? 1029 PHE C CE2 1 
ATOM   5292 C CZ  . PHE C 1 179 ? -45.774  64.229 49.873  1.00 37.80  ? 1029 PHE C CZ  1 
ATOM   5293 N N   . MET C 1 180 ? -48.549  59.551 51.789  1.00 34.58  ? 1030 MET C N   1 
ATOM   5294 C CA  . MET C 1 180 ? -48.001  59.306 53.112  1.00 33.50  ? 1030 MET C CA  1 
ATOM   5295 C C   . MET C 1 180 ? -47.380  57.912 53.192  1.00 28.47  ? 1030 MET C C   1 
ATOM   5296 O O   . MET C 1 180 ? -46.352  57.714 53.871  1.00 33.08  ? 1030 MET C O   1 
ATOM   5297 C CB  . MET C 1 180 ? -49.126  59.529 54.119  1.00 31.40  ? 1030 MET C CB  1 
ATOM   5298 C CG  . MET C 1 180 ? -49.278  61.009 54.461  1.00 32.01  ? 1030 MET C CG  1 
ATOM   5299 S SD  . MET C 1 180 ? -50.124  61.364 56.003  1.00 35.27  ? 1030 MET C SD  1 
ATOM   5300 C CE  . MET C 1 180 ? -51.665  60.504 55.710  1.00 35.98  ? 1030 MET C CE  1 
ATOM   5301 N N   . ASP C 1 181 ? -47.935  56.948 52.450  1.00 29.88  ? 1031 ASP C N   1 
ATOM   5302 C CA  . ASP C 1 181 ? -47.313  55.633 52.412  1.00 32.31  ? 1031 ASP C CA  1 
ATOM   5303 C C   . ASP C 1 181 ? -45.930  55.691 51.778  1.00 38.55  ? 1031 ASP C C   1 
ATOM   5304 O O   . ASP C 1 181 ? -45.020  54.981 52.213  1.00 33.04  ? 1031 ASP C O   1 
ATOM   5305 C CB  . ASP C 1 181 ? -48.183  54.634 51.659  1.00 33.24  ? 1031 ASP C CB  1 
ATOM   5306 C CG  . ASP C 1 181 ? -47.705  53.209 51.854  1.00 38.21  ? 1031 ASP C CG  1 
ATOM   5307 O OD1 . ASP C 1 181 ? -47.810  52.703 52.991  1.00 39.33  ? 1031 ASP C OD1 1 
ATOM   5308 O OD2 . ASP C 1 181 ? -47.185  52.612 50.888  1.00 35.73  ? 1031 ASP C OD2 1 
ATOM   5309 N N   . THR C 1 182 ? -45.749  56.508 50.736  1.00 32.63  ? 1032 THR C N   1 
ATOM   5310 C CA  . THR C 1 182 ? -44.415  56.587 50.143  1.00 36.04  ? 1032 THR C CA  1 
ATOM   5311 C C   . THR C 1 182 ? -43.424  57.287 51.066  1.00 35.78  ? 1032 THR C C   1 
ATOM   5312 O O   . THR C 1 182 ? -42.221  57.000 51.000  1.00 38.23  ? 1032 THR C O   1 
ATOM   5313 C CB  . THR C 1 182 ? -44.454  57.270 48.769  1.00 33.79  ? 1032 THR C CB  1 
ATOM   5314 O OG1 . THR C 1 182 ? -44.963  58.604 48.888  1.00 34.18  ? 1032 THR C OG1 1 
ATOM   5315 C CG2 . THR C 1 182 ? -45.323  56.471 47.805  1.00 35.15  ? 1032 THR C CG2 1 
ATOM   5316 N N   . MET C 1 183 ? -43.907  58.147 51.967  1.00 32.88  ? 1033 MET C N   1 
ATOM   5317 C CA  . MET C 1 183 ? -43.016  58.641 53.024  1.00 33.02  ? 1033 MET C CA  1 
ATOM   5318 C C   . MET C 1 183 ? -42.558  57.506 53.945  1.00 40.56  ? 1033 MET C C   1 
ATOM   5319 O O   . MET C 1 183 ? -41.372  57.414 54.312  1.00 37.41  ? 1033 MET C O   1 
ATOM   5320 C CB  . MET C 1 183 ? -43.709  59.738 53.834  1.00 34.98  ? 1033 MET C CB  1 
ATOM   5321 C CG  . MET C 1 183 ? -44.298  60.857 52.997  1.00 35.00  ? 1033 MET C CG  1 
ATOM   5322 S SD  . MET C 1 183 ? -45.170  62.081 53.988  1.00 33.85  ? 1033 MET C SD  1 
ATOM   5323 C CE  . MET C 1 183 ? -43.842  62.795 54.955  1.00 34.34  ? 1033 MET C CE  1 
ATOM   5324 N N   . LEU C 1 184 ? -43.482  56.615 54.316  1.00 34.96  ? 1034 LEU C N   1 
ATOM   5325 C CA  . LEU C 1 184 ? -43.063  55.445 55.097  1.00 33.10  ? 1034 LEU C CA  1 
ATOM   5326 C C   . LEU C 1 184 ? -42.141  54.517 54.296  1.00 42.40  ? 1034 LEU C C   1 
ATOM   5327 O O   . LEU C 1 184 ? -41.240  53.886 54.866  1.00 37.62  ? 1034 LEU C O   1 
ATOM   5328 C CB  . LEU C 1 184 ? -44.284  54.684 55.614  1.00 34.91  ? 1034 LEU C CB  1 
ATOM   5329 C CG  . LEU C 1 184 ? -45.197  55.467 56.565  1.00 35.28  ? 1034 LEU C CG  1 
ATOM   5330 C CD1 . LEU C 1 184 ? -46.285  54.564 57.124  1.00 33.64  ? 1034 LEU C CD1 1 
ATOM   5331 C CD2 . LEU C 1 184 ? -44.408  56.121 57.697  1.00 36.43  ? 1034 LEU C CD2 1 
ATOM   5332 N N   . GLN C 1 185 ? -42.360  54.408 52.984  1.00 34.13  ? 1035 GLN C N   1 
ATOM   5333 C CA  . GLN C 1 185 ? -41.473  53.612 52.138  1.00 37.06  ? 1035 GLN C CA  1 
ATOM   5334 C C   . GLN C 1 185 ? -40.058  54.170 52.165  1.00 35.24  ? 1035 GLN C C   1 
ATOM   5335 O O   . GLN C 1 185 ? -39.079  53.418 52.268  1.00 44.75  ? 1035 GLN C O   1 
ATOM   5336 C CB  . GLN C 1 185 ? -41.991  53.597 50.700  1.00 35.48  ? 1035 GLN C CB  1 
ATOM   5337 C CG  . GLN C 1 185 ? -43.297  52.861 50.476  1.00 35.80  ? 1035 GLN C CG  1 
ATOM   5338 C CD  . GLN C 1 185 ? -43.820  53.050 49.062  1.00 43.82  ? 1035 GLN C CD  1 
ATOM   5339 O OE1 . GLN C 1 185 ? -43.055  53.327 48.138  1.00 39.99  ? 1035 GLN C OE1 1 
ATOM   5340 N NE2 . GLN C 1 185 ? -45.129  52.906 48.890  1.00 36.37  ? 1035 GLN C NE2 1 
ATOM   5341 N N   . MET C 1 186 ? -39.940  55.498 52.080  1.00 37.44  ? 1036 MET C N   1 
ATOM   5342 C CA  . MET C 1 186 ? -38.636  56.144 52.164  1.00 41.57  ? 1036 MET C CA  1 
ATOM   5343 C C   . MET C 1 186 ? -37.982  55.823 53.493  1.00 49.33  ? 1036 MET C C   1 
ATOM   5344 O O   . MET C 1 186 ? -36.763  55.617 53.570  1.00 42.76  ? 1036 MET C O   1 
ATOM   5345 C CB  . MET C 1 186 ? -38.797  57.654 52.020  1.00 38.14  ? 1036 MET C CB  1 
ATOM   5346 C CG  . MET C 1 186 ? -39.025  58.116 50.608  1.00 37.60  ? 1036 MET C CG  1 
ATOM   5347 S SD  . MET C 1 186 ? -37.616  57.776 49.546  1.00 43.10  ? 1036 MET C SD  1 
ATOM   5348 C CE  . MET C 1 186 ? -36.318  58.628 50.437  1.00 42.47  ? 1036 MET C CE  1 
ATOM   5349 N N   . SER C 1 187 ? -38.730  55.785 54.591  1.00 43.30  ? 1037 SER C N   1 
ATOM   5350 C CA  . SER C 1 187 ? -38.120  55.553 55.928  1.00 46.79  ? 1037 SER C CA  1 
ATOM   5351 C C   . SER C 1 187 ? -37.518  54.159 55.974  1.00 49.42  ? 1037 SER C C   1 
ATOM   5352 O O   . SER C 1 187 ? -36.565  53.980 56.704  1.00 61.44  ? 1037 SER C O   1 
ATOM   5353 C CB  . SER C 1 187 ? -39.115  55.733 57.037  1.00 48.33  ? 1037 SER C CB  1 
ATOM   5354 O OG  . SER C 1 187 ? -39.853  56.934 56.878  1.00 51.46  ? 1037 SER C OG  1 
ATOM   5355 N N   . ILE C 1 188 ? -38.040  53.241 55.185  1.00 48.97  ? 1038 ILE C N   1 
ATOM   5356 C CA  . ILE C 1 188 ? -37.590  51.825 55.150  1.00 52.19  ? 1038 ILE C CA  1 
ATOM   5357 C C   . ILE C 1 188 ? -36.412  51.651 54.203  1.00 53.63  ? 1038 ILE C C   1 
ATOM   5358 O O   . ILE C 1 188 ? -35.576  50.803 54.476  1.00 52.53  ? 1038 ILE C O   1 
ATOM   5359 C CB  . ILE C 1 188 ? -38.766  50.952 54.657  1.00 51.94  ? 1038 ILE C CB  1 
ATOM   5360 C CG1 . ILE C 1 188 ? -39.549  50.353 55.826  1.00 58.86  ? 1038 ILE C CG1 1 
ATOM   5361 C CG2 . ILE C 1 188 ? -38.290  49.877 53.695  1.00 54.93  ? 1038 ILE C CG2 1 
ATOM   5362 C CD1 . ILE C 1 188 ? -39.512  51.196 57.083  1.00 56.57  ? 1038 ILE C CD1 1 
ATOM   5363 N N   . LEU C 1 189 ? -36.353  52.441 53.140  1.00 52.99  ? 1039 LEU C N   1 
ATOM   5364 C CA  . LEU C 1 189 ? -35.340  52.215 52.077  1.00 53.66  ? 1039 LEU C CA  1 
ATOM   5365 C C   . LEU C 1 189 ? -33.919  52.214 52.641  1.00 50.31  ? 1039 LEU C C   1 
ATOM   5366 O O   . LEU C 1 189 ? -33.139  51.367 52.239  1.00 55.22  ? 1039 LEU C O   1 
ATOM   5367 C CB  . LEU C 1 189 ? -35.526  53.296 51.013  1.00 53.66  ? 1039 LEU C CB  1 
ATOM   5368 C CG  . LEU C 1 189 ? -35.044  52.940 49.612  1.00 49.92  ? 1039 LEU C CG  1 
ATOM   5369 C CD1 . LEU C 1 189 ? -35.671  51.641 49.149  1.00 48.80  ? 1039 LEU C CD1 1 
ATOM   5370 C CD2 . LEU C 1 189 ? -35.376  54.062 48.649  1.00 53.13  ? 1039 LEU C CD2 1 
ATOM   5371 N N   . GLY C 1 190 ? -33.620  53.134 53.536  1.00 49.86  ? 1040 GLY C N   1 
ATOM   5372 C CA  . GLY C 1 190 ? -32.262  53.235 54.078  1.00 59.16  ? 1040 GLY C CA  1 
ATOM   5373 C C   . GLY C 1 190 ? -31.959  52.175 55.118  1.00 61.26  ? 1040 GLY C C   1 
ATOM   5374 O O   . GLY C 1 190 ? -30.818  52.104 55.554  1.00 62.11  ? 1040 GLY C O   1 
ATOM   5375 N N   . SER C 1 191 ? -32.953  51.389 55.500  1.00 52.23  ? 1041 SER C N   1 
ATOM   5376 C CA  . SER C 1 191 ? -32.716  50.402 56.569  1.00 61.87  ? 1041 SER C CA  1 
ATOM   5377 C C   . SER C 1 191 ? -31.865  49.265 56.025  1.00 60.91  ? 1041 SER C C   1 
ATOM   5378 O O   . SER C 1 191 ? -31.965  48.957 54.845  1.00 58.22  ? 1041 SER C O   1 
ATOM   5379 C CB  . SER C 1 191 ? -33.980  49.863 57.183  1.00 57.37  ? 1041 SER C CB  1 
ATOM   5380 O OG  . SER C 1 191 ? -33.701  49.296 58.445  1.00 62.69  ? 1041 SER C OG  1 
ATOM   5381 N N   . ALA C 1 192 ? -31.085  48.660 56.905  1.00 64.52  ? 1042 ALA C N   1 
ATOM   5382 C CA  . ALA C 1 192 ? -30.271  47.502 56.509  1.00 63.85  ? 1042 ALA C CA  1 
ATOM   5383 C C   . ALA C 1 192 ? -30.867  46.274 57.166  1.00 66.77  ? 1042 ALA C C   1 
ATOM   5384 O O   . ALA C 1 192 ? -30.373  45.170 56.947  1.00 67.66  ? 1042 ALA C O   1 
ATOM   5385 C CB  . ALA C 1 192 ? -28.875  47.709 56.979  1.00 65.93  ? 1042 ALA C CB  1 
ATOM   5386 N N   . LYS C 1 193 ? -31.881  46.498 57.973  1.00 66.06  ? 1043 LYS C N   1 
ATOM   5387 C CA  . LYS C 1 193 ? -32.555  45.346 58.574  1.00 62.78  ? 1043 LYS C CA  1 
ATOM   5388 C C   . LYS C 1 193 ? -32.964  44.476 57.402  1.00 70.53  ? 1043 LYS C C   1 
ATOM   5389 O O   . LYS C 1 193 ? -33.328  45.022 56.354  1.00 68.73  ? 1043 LYS C O   1 
ATOM   5390 C CB  . LYS C 1 193 ? -33.736  45.803 59.423  1.00 68.00  ? 1043 LYS C CB  1 
ATOM   5391 C CG  . LYS C 1 193 ? -33.384  46.713 60.590  1.00 66.38  ? 1043 LYS C CG  1 
ATOM   5392 C CD  . LYS C 1 193 ? -34.597  47.305 61.264  1.00 67.19  ? 1043 LYS C CD  1 
ATOM   5393 C CE  . LYS C 1 193 ? -34.250  48.445 62.195  1.00 70.80  ? 1043 LYS C CE  1 
ATOM   5394 N NZ  . LYS C 1 193 ? -35.386  49.381 62.359  1.00 74.52  ? 1043 LYS C NZ  1 
ATOM   5395 N N   . HIS C 1 194 ? -32.861  43.173 57.568  1.00 69.77  ? 1044 HIS C N   1 
ATOM   5396 C CA  . HIS C 1 194 ? -33.346  42.303 56.483  1.00 68.83  ? 1044 HIS C CA  1 
ATOM   5397 C C   . HIS C 1 194 ? -34.756  41.875 56.848  1.00 65.97  ? 1044 HIS C C   1 
ATOM   5398 O O   . HIS C 1 194 ? -35.054  41.676 58.028  1.00 68.17  ? 1044 HIS C O   1 
ATOM   5399 C CB  . HIS C 1 194 ? -32.437  41.089 56.289  1.00 73.46  ? 1044 HIS C CB  1 
ATOM   5400 C CG  . HIS C 1 194 ? -31.042  41.377 55.851  1.00 76.06  ? 1044 HIS C CG  1 
ATOM   5401 N ND1 . HIS C 1 194 ? -29.951  40.809 56.469  1.00 74.81  ? 1044 HIS C ND1 1 
ATOM   5402 C CD2 . HIS C 1 194 ? -30.555  42.111 54.844  1.00 79.43  ? 1044 HIS C CD2 1 
ATOM   5403 C CE1 . HIS C 1 194 ? -28.846  41.218 55.865  1.00 77.88  ? 1044 HIS C CE1 1 
ATOM   5404 N NE2 . HIS C 1 194 ? -29.188  42.013 54.878  1.00 79.50  ? 1044 HIS C NE2 1 
ATOM   5405 N N   . GLY C 1 195 ? -35.618  41.816 55.845  1.00 61.41  ? 1045 GLY C N   1 
ATOM   5406 C CA  . GLY C 1 195 ? -36.963  41.286 56.094  1.00 63.45  ? 1045 GLY C CA  1 
ATOM   5407 C C   . GLY C 1 195 ? -38.044  42.338 56.092  1.00 58.63  ? 1045 GLY C C   1 
ATOM   5408 O O   . GLY C 1 195 ? -37.745  43.514 55.855  1.00 57.91  ? 1045 GLY C O   1 
ATOM   5409 N N   . LEU C 1 196 ? -39.255  41.888 56.369  1.00 60.89  ? 1046 LEU C N   1 
ATOM   5410 C CA  . LEU C 1 196 ? -40.403  42.810 56.370  1.00 58.56  ? 1046 LEU C CA  1 
ATOM   5411 C C   . LEU C 1 196 ? -40.553  43.437 57.745  1.00 50.62  ? 1046 LEU C C   1 
ATOM   5412 O O   . LEU C 1 196 ? -40.660  42.703 58.713  1.00 58.23  ? 1046 LEU C O   1 
ATOM   5413 C CB  . LEU C 1 196 ? -41.668  42.052 55.973  1.00 59.06  ? 1046 LEU C CB  1 
ATOM   5414 C CG  . LEU C 1 196 ? -42.900  42.922 55.747  1.00 57.67  ? 1046 LEU C CG  1 
ATOM   5415 C CD1 . LEU C 1 196 ? -42.756  43.724 54.467  1.00 63.33  ? 1046 LEU C CD1 1 
ATOM   5416 C CD2 . LEU C 1 196 ? -44.149  42.063 55.698  1.00 63.12  ? 1046 LEU C CD2 1 
ATOM   5417 N N   . TYR C 1 197 ? -40.482  44.752 57.786  1.00 55.54  ? 1047 TYR C N   1 
ATOM   5418 C CA  . TYR C 1 197 ? -40.770  45.489 59.029  1.00 51.78  ? 1047 TYR C CA  1 
ATOM   5419 C C   . TYR C 1 197 ? -42.028  46.322 58.756  1.00 51.53  ? 1047 TYR C C   1 
ATOM   5420 O O   . TYR C 1 197 ? -42.098  46.988 57.721  1.00 48.87  ? 1047 TYR C O   1 
ATOM   5421 C CB  . TYR C 1 197 ? -39.571  46.316 59.473  1.00 50.60  ? 1047 TYR C CB  1 
ATOM   5422 C CG  . TYR C 1 197 ? -38.516  45.530 60.203  1.00 52.49  ? 1047 TYR C CG  1 
ATOM   5423 C CD1 . TYR C 1 197 ? -37.784  44.548 59.562  1.00 56.13  ? 1047 TYR C CD1 1 
ATOM   5424 C CD2 . TYR C 1 197 ? -38.275  45.748 61.546  1.00 53.50  ? 1047 TYR C CD2 1 
ATOM   5425 C CE1 . TYR C 1 197 ? -36.820  43.816 60.232  1.00 56.99  ? 1047 TYR C CE1 1 
ATOM   5426 C CE2 . TYR C 1 197 ? -37.317  45.023 62.234  1.00 56.37  ? 1047 TYR C CE2 1 
ATOM   5427 C CZ  . TYR C 1 197 ? -36.587  44.053 61.574  1.00 62.36  ? 1047 TYR C CZ  1 
ATOM   5428 O OH  . TYR C 1 197 ? -35.639  43.334 62.252  1.00 63.91  ? 1047 TYR C OH  1 
ATOM   5429 N N   . LEU C 1 198 ? -42.992  46.238 59.654  1.00 44.82  ? 1048 LEU C N   1 
ATOM   5430 C CA  . LEU C 1 198 ? -44.256  46.985 59.509  1.00 41.61  ? 1048 LEU C CA  1 
ATOM   5431 C C   . LEU C 1 198 ? -44.379  47.998 60.647  1.00 39.61  ? 1048 LEU C C   1 
ATOM   5432 O O   . LEU C 1 198 ? -43.833  47.771 61.714  1.00 36.77  ? 1048 LEU C O   1 
ATOM   5433 C CB  . LEU C 1 198 ? -45.403  45.979 59.545  1.00 43.33  ? 1048 LEU C CB  1 
ATOM   5434 C CG  . LEU C 1 198 ? -45.944  45.510 58.199  1.00 45.51  ? 1048 LEU C CG  1 
ATOM   5435 C CD1 . LEU C 1 198 ? -45.011  45.900 57.070  1.00 51.59  ? 1048 LEU C CD1 1 
ATOM   5436 C CD2 . LEU C 1 198 ? -46.174  44.013 58.218  1.00 50.74  ? 1048 LEU C CD2 1 
ATOM   5437 N N   . PRO C 1 199 ? -45.089  49.110 60.420  1.00 36.93  ? 1049 PRO C N   1 
ATOM   5438 C CA  . PRO C 1 199 ? -45.263  50.115 61.441  1.00 31.05  ? 1049 PRO C CA  1 
ATOM   5439 C C   . PRO C 1 199 ? -46.033  49.616 62.676  1.00 34.00  ? 1049 PRO C C   1 
ATOM   5440 O O   . PRO C 1 199 ? -46.969  48.901 62.504  1.00 33.42  ? 1049 PRO C O   1 
ATOM   5441 C CB  . PRO C 1 199 ? -46.052  51.184 60.683  1.00 34.82  ? 1049 PRO C CB  1 
ATOM   5442 C CG  . PRO C 1 199 ? -45.725  50.956 59.241  1.00 38.45  ? 1049 PRO C CG  1 
ATOM   5443 C CD  . PRO C 1 199 ? -45.704  49.454 59.147  1.00 36.01  ? 1049 PRO C CD  1 
ATOM   5444 N N   . THR C 1 200 ? -45.622  50.064 63.860  1.00 29.45  ? 1050 THR C N   1 
ATOM   5445 C CA  . THR C 1 200 ? -46.247  49.630 65.134  1.00 29.61  ? 1050 THR C CA  1 
ATOM   5446 C C   . THR C 1 200 ? -46.683  50.848 65.938  1.00 32.88  ? 1050 THR C C   1 
ATOM   5447 O O   . THR C 1 200 ? -47.703  50.775 66.608  1.00 30.12  ? 1050 THR C O   1 
ATOM   5448 C CB  . THR C 1 200 ? -45.263  48.746 65.907  1.00 35.08  ? 1050 THR C CB  1 
ATOM   5449 O OG1 . THR C 1 200 ? -44.030  49.435 66.097  1.00 34.02  ? 1050 THR C OG1 1 
ATOM   5450 C CG2 . THR C 1 200 ? -45.035  47.433 65.197  1.00 40.31  ? 1050 THR C CG2 1 
ATOM   5451 N N   . ARG C 1 201 ? -45.895  51.913 65.873  1.00 28.76  ? 1051 ARG C N   1 
ATOM   5452 C CA  . ARG C 1 201 ? -46.207  53.144 66.624  1.00 26.39  ? 1051 ARG C CA  1 
ATOM   5453 C C   . ARG C 1 201 ? -45.675  54.369 65.886  1.00 34.76  ? 1051 ARG C C   1 
ATOM   5454 O O   . ARG C 1 201 ? -44.698  54.234 65.163  1.00 36.18  ? 1051 ARG C O   1 
ATOM   5455 C CB  . ARG C 1 201 ? -45.581  53.097 68.016  1.00 31.31  ? 1051 ARG C CB  1 
ATOM   5456 C CG  . ARG C 1 201 ? -46.085  51.995 68.932  1.00 39.03  ? 1051 ARG C CG  1 
ATOM   5457 C CD  . ARG C 1 201 ? -45.626  52.213 70.361  1.00 38.22  ? 1051 ARG C CD  1 
ATOM   5458 N NE  . ARG C 1 201 ? -46.028  51.108 71.216  1.00 43.77  ? 1051 ARG C NE  1 
ATOM   5459 C CZ  . ARG C 1 201 ? -46.826  51.212 72.269  1.00 40.08  ? 1051 ARG C CZ  1 
ATOM   5460 N NH1 . ARG C 1 201 ? -47.184  52.400 72.716  1.00 44.21  ? 1051 ARG C NH1 1 
ATOM   5461 N NH2 . ARG C 1 201 ? -47.257  50.124 72.877  1.00 43.39  ? 1051 ARG C NH2 1 
ATOM   5462 N N   . VAL C 1 202 ? -46.315  55.507 66.068  1.00 30.25  ? 1052 VAL C N   1 
ATOM   5463 C CA  . VAL C 1 202 ? -45.807  56.779 65.498  1.00 30.29  ? 1052 VAL C CA  1 
ATOM   5464 C C   . VAL C 1 202 ? -46.063  57.845 66.558  1.00 34.23  ? 1052 VAL C C   1 
ATOM   5465 O O   . VAL C 1 202 ? -47.209  58.077 66.894  1.00 30.83  ? 1052 VAL C O   1 
ATOM   5466 C CB  . VAL C 1 202 ? -46.439  57.121 64.141  1.00 29.83  ? 1052 VAL C CB  1 
ATOM   5467 C CG1 . VAL C 1 202 ? -45.703  58.272 63.477  1.00 33.15  ? 1052 VAL C CG1 1 
ATOM   5468 C CG2 . VAL C 1 202 ? -46.511  55.923 63.213  1.00 29.86  ? 1052 VAL C CG2 1 
ATOM   5469 N N   . THR C 1 203 ? -45.000  58.467 67.056  1.00 28.98  ? 1053 THR C N   1 
ATOM   5470 C CA  . THR C 1 203 ? -45.150  59.445 68.155  1.00 29.30  ? 1053 THR C CA  1 
ATOM   5471 C C   . THR C 1 203 ? -45.999  60.626 67.690  1.00 32.65  ? 1053 THR C C   1 
ATOM   5472 O O   . THR C 1 203 ? -46.854  61.039 68.448  1.00 31.50  ? 1053 THR C O   1 
ATOM   5473 C CB  . THR C 1 203 ? -43.778  59.829 68.731  1.00 33.74  ? 1053 THR C CB  1 
ATOM   5474 O OG1 . THR C 1 203 ? -43.050  58.627 68.968  1.00 34.34  ? 1053 THR C OG1 1 
ATOM   5475 C CG2 . THR C 1 203 ? -43.884  60.662 69.987  1.00 36.99  ? 1053 THR C CG2 1 
ATOM   5476 N N   . ALA C 1 204 ? -45.733  61.166 66.506  1.00 28.71  ? 1054 ALA C N   1 
ATOM   5477 C CA  . ALA C 1 204 ? -46.529  62.323 66.122  1.00 30.33  ? 1054 ALA C CA  1 
ATOM   5478 C C   . ALA C 1 204 ? -46.533  62.485 64.610  1.00 34.94  ? 1054 ALA C C   1 
ATOM   5479 O O   . ALA C 1 204 ? -45.524  62.250 63.948  1.00 35.30  ? 1054 ALA C O   1 
ATOM   5480 C CB  . ALA C 1 204 ? -46.015  63.602 66.792  1.00 34.14  ? 1054 ALA C CB  1 
ATOM   5481 N N   . ILE C 1 205 ? -47.682  62.876 64.073  1.00 32.20  ? 1055 ILE C N   1 
ATOM   5482 C CA  . ILE C 1 205 ? -47.813  63.209 62.661  1.00 30.37  ? 1055 ILE C CA  1 
ATOM   5483 C C   . ILE C 1 205 ? -48.533  64.544 62.553  1.00 35.18  ? 1055 ILE C C   1 
ATOM   5484 O O   . ILE C 1 205 ? -49.604  64.724 63.136  1.00 31.73  ? 1055 ILE C O   1 
ATOM   5485 C CB  . ILE C 1 205 ? -48.569  62.118 61.880  1.00 37.25  ? 1055 ILE C CB  1 
ATOM   5486 C CG1 . ILE C 1 205 ? -47.815  60.792 61.966  1.00 37.12  ? 1055 ILE C CG1 1 
ATOM   5487 C CG2 . ILE C 1 205 ? -48.735  62.529 60.427  1.00 33.52  ? 1055 ILE C CG2 1 
ATOM   5488 C CD1 . ILE C 1 205 ? -48.677  59.584 61.716  1.00 39.96  ? 1055 ILE C CD1 1 
ATOM   5489 N N   . HIS C 1 206 ? -47.935  65.485 61.833  1.00 32.60  ? 1056 HIS C N   1 
ATOM   5490 C CA  . HIS C 1 206 ? -48.560  66.769 61.547  1.00 34.99  ? 1056 HIS C CA  1 
ATOM   5491 C C   . HIS C 1 206 ? -48.866  66.848 60.057  1.00 37.11  ? 1056 HIS C C   1 
ATOM   5492 O O   . HIS C 1 206 ? -48.023  66.477 59.232  1.00 32.06  ? 1056 HIS C O   1 
ATOM   5493 C CB  . HIS C 1 206 ? -47.651  67.930 61.963  1.00 35.55  ? 1056 HIS C CB  1 
ATOM   5494 C CG  . HIS C 1 206 ? -47.500  68.092 63.446  1.00 31.89  ? 1056 HIS C CG  1 
ATOM   5495 N ND1 . HIS C 1 206 ? -46.799  67.196 64.225  1.00 35.30  ? 1056 HIS C ND1 1 
ATOM   5496 C CD2 . HIS C 1 206 ? -47.938  69.058 64.288  1.00 33.38  ? 1056 HIS C CD2 1 
ATOM   5497 C CE1 . HIS C 1 206 ? -46.822  67.597 65.484  1.00 32.86  ? 1056 HIS C CE1 1 
ATOM   5498 N NE2 . HIS C 1 206 ? -47.507  68.725 65.549  1.00 33.72  ? 1056 HIS C NE2 1 
ATOM   5499 N N   . ILE C 1 207 ? -50.074  67.302 59.713  1.00 34.44  ? 1057 ILE C N   1 
ATOM   5500 C CA  . ILE C 1 207 ? -50.445  67.542 58.320  1.00 33.37  ? 1057 ILE C CA  1 
ATOM   5501 C C   . ILE C 1 207 ? -51.046  68.938 58.215  1.00 35.36  ? 1057 ILE C C   1 
ATOM   5502 O O   . ILE C 1 207 ? -52.008  69.256 58.925  1.00 33.11  ? 1057 ILE C O   1 
ATOM   5503 C CB  . ILE C 1 207 ? -51.454  66.505 57.786  1.00 34.60  ? 1057 ILE C CB  1 
ATOM   5504 C CG1 . ILE C 1 207 ? -50.919  65.080 57.899  1.00 33.12  ? 1057 ILE C CG1 1 
ATOM   5505 C CG2 . ILE C 1 207 ? -51.776  66.789 56.326  1.00 32.98  ? 1057 ILE C CG2 1 
ATOM   5506 C CD1 . ILE C 1 207 ? -52.005  64.034 57.705  1.00 35.46  ? 1057 ILE C CD1 1 
ATOM   5507 N N   . ASP C 1 208 ? -50.500  69.757 57.317  1.00 36.23  ? 1058 ASP C N   1 
ATOM   5508 C CA  . ASP C 1 208 ? -51.069  71.068 57.000  1.00 40.27  ? 1058 ASP C CA  1 
ATOM   5509 C C   . ASP C 1 208 ? -51.261  71.136 55.490  1.00 43.07  ? 1058 ASP C C   1 
ATOM   5510 O O   . ASP C 1 208 ? -50.291  71.371 54.747  1.00 38.49  ? 1058 ASP C O   1 
ATOM   5511 C CB  . ASP C 1 208 ? -50.180  72.205 57.495  1.00 45.39  ? 1058 ASP C CB  1 
ATOM   5512 C CG  . ASP C 1 208 ? -50.764  73.582 57.201  1.00 47.55  ? 1058 ASP C CG  1 
ATOM   5513 O OD1 . ASP C 1 208 ? -52.006  73.715 57.170  1.00 47.80  ? 1058 ASP C OD1 1 
ATOM   5514 O OD2 . ASP C 1 208 ? -49.979  74.538 57.021  1.00 44.18  ? 1058 ASP C OD2 1 
ATOM   5515 N N   . PRO C 1 209 ? -52.482  70.922 54.997  1.00 36.99  ? 1059 PRO C N   1 
ATOM   5516 C CA  . PRO C 1 209 ? -52.693  70.940 53.538  1.00 39.00  ? 1059 PRO C CA  1 
ATOM   5517 C C   . PRO C 1 209 ? -52.323  72.263 52.871  1.00 39.44  ? 1059 PRO C C   1 
ATOM   5518 O O   . PRO C 1 209 ? -51.917  72.258 51.701  1.00 43.20  ? 1059 PRO C O   1 
ATOM   5519 C CB  . PRO C 1 209 ? -54.188  70.604 53.393  1.00 40.62  ? 1059 PRO C CB  1 
ATOM   5520 C CG  . PRO C 1 209 ? -54.769  70.688 54.785  1.00 42.89  ? 1059 PRO C CG  1 
ATOM   5521 C CD  . PRO C 1 209 ? -53.655  70.415 55.727  1.00 39.56  ? 1059 PRO C CD  1 
ATOM   5522 N N   . ALA C 1 210 ? -52.425  73.393 53.579  1.00 39.53  ? 1060 ALA C N   1 
ATOM   5523 C CA  . ALA C 1 210 ? -52.052  74.679 52.988  1.00 43.88  ? 1060 ALA C CA  1 
ATOM   5524 C C   . ALA C 1 210 ? -50.549  74.741 52.698  1.00 46.33  ? 1060 ALA C C   1 
ATOM   5525 O O   . ALA C 1 210 ? -50.118  75.093 51.581  1.00 47.39  ? 1060 ALA C O   1 
ATOM   5526 C CB  . ALA C 1 210 ? -52.483  75.814 53.922  1.00 43.05  ? 1060 ALA C CB  1 
ATOM   5527 N N   . THR C 1 211 ? -49.732  74.383 53.691  1.00 46.51  ? 1061 THR C N   1 
ATOM   5528 C CA  . THR C 1 211 ? -48.296  74.285 53.452  1.00 45.29  ? 1061 THR C CA  1 
ATOM   5529 C C   . THR C 1 211 ? -47.995  73.235 52.389  1.00 45.78  ? 1061 THR C C   1 
ATOM   5530 O O   . THR C 1 211 ? -47.116  73.435 51.539  1.00 47.36  ? 1061 THR C O   1 
ATOM   5531 C CB  . THR C 1 211 ? -47.562  73.969 54.758  1.00 43.73  ? 1061 THR C CB  1 
ATOM   5532 O OG1 . THR C 1 211 ? -47.795  75.018 55.708  1.00 44.92  ? 1061 THR C OG1 1 
ATOM   5533 C CG2 . THR C 1 211 ? -46.063  73.832 54.515  1.00 44.19  ? 1061 THR C CG2 1 
ATOM   5534 N N   . HIS C 1 212 ? -48.729  72.117 52.412  1.00 37.03  ? 1062 HIS C N   1 
ATOM   5535 C CA  . HIS C 1 212 ? -48.544  71.074 51.405  1.00 36.82  ? 1062 HIS C CA  1 
ATOM   5536 C C   . HIS C 1 212 ? -48.670  71.633 49.995  1.00 44.09  ? 1062 HIS C C   1 
ATOM   5537 O O   . HIS C 1 212 ? -47.848  71.334 49.122  1.00 44.72  ? 1062 HIS C O   1 
ATOM   5538 C CB  . HIS C 1 212 ? -49.555  69.945 51.610  1.00 39.65  ? 1062 HIS C CB  1 
ATOM   5539 C CG  . HIS C 1 212 ? -49.263  68.723 50.795  1.00 32.77  ? 1062 HIS C CG  1 
ATOM   5540 N ND1 . HIS C 1 212 ? -48.178  67.910 51.038  1.00 33.42  ? 1062 HIS C ND1 1 
ATOM   5541 C CD2 . HIS C 1 212 ? -49.905  68.184 49.731  1.00 34.37  ? 1062 HIS C CD2 1 
ATOM   5542 C CE1 . HIS C 1 212 ? -48.168  66.918 50.165  1.00 33.33  ? 1062 HIS C CE1 1 
ATOM   5543 N NE2 . HIS C 1 212 ? -49.206  67.061 49.360  1.00 36.40  ? 1062 HIS C NE2 1 
ATOM   5544 N N   . ARG C 1 213 ? -49.705  72.442 49.750  1.00 43.50  ? 1063 ARG C N   1 
ATOM   5545 C CA  . ARG C 1 213 ? -49.891  72.981 48.406  1.00 46.57  ? 1063 ARG C CA  1 
ATOM   5546 C C   . ARG C 1 213 ? -48.771  73.949 48.042  1.00 47.31  ? 1063 ARG C C   1 
ATOM   5547 O O   . ARG C 1 213 ? -48.351  74.006 46.879  1.00 49.84  ? 1063 ARG C O   1 
ATOM   5548 C CB  . ARG C 1 213 ? -51.249  73.673 48.287  1.00 48.21  ? 1063 ARG C CB  1 
ATOM   5549 C CG  . ARG C 1 213 ? -52.438  72.804 48.668  1.00 46.10  ? 1063 ARG C CG  1 
ATOM   5550 C CD  . ARG C 1 213 ? -53.088  72.119 47.474  1.00 55.72  ? 1063 ARG C CD  1 
ATOM   5551 N NE  . ARG C 1 213 ? -53.949  71.024 47.906  1.00 53.84  ? 1063 ARG C NE  1 
ATOM   5552 C CZ  . ARG C 1 213 ? -54.184  69.924 47.203  1.00 53.08  ? 1063 ARG C CZ  1 
ATOM   5553 N NH1 . ARG C 1 213 ? -53.656  69.744 46.004  1.00 59.34  ? 1063 ARG C NH1 1 
ATOM   5554 N NH2 . ARG C 1 213 ? -54.970  68.982 47.717  1.00 51.24  ? 1063 ARG C NH2 1 
ATOM   5555 N N   . GLN C 1 214 ? -48.283  74.725 49.019  1.00 49.13  ? 1064 GLN C N   1 
ATOM   5556 C CA  . GLN C 1 214 ? -47.168  75.633 48.727  1.00 50.83  ? 1064 GLN C CA  1 
ATOM   5557 C C   . GLN C 1 214 ? -45.876  74.889 48.383  1.00 49.86  ? 1064 GLN C C   1 
ATOM   5558 O O   . GLN C 1 214 ? -45.042  75.414 47.632  1.00 52.90  ? 1064 GLN C O   1 
ATOM   5559 C CB  . GLN C 1 214 ? -46.919  76.582 49.898  1.00 47.24  ? 1064 GLN C CB  1 
ATOM   5560 C CG  . GLN C 1 214 ? -48.095  77.468 50.257  1.00 59.47  ? 1064 GLN C CG  1 
ATOM   5561 C CD  . GLN C 1 214 ? -47.867  78.220 51.555  1.00 63.66  ? 1064 GLN C CD  1 
ATOM   5562 O OE1 . GLN C 1 214 ? -48.079  79.431 51.633  1.00 73.26  ? 1064 GLN C OE1 1 
ATOM   5563 N NE2 . GLN C 1 214 ? -47.417  77.505 52.581  1.00 63.49  ? 1064 GLN C NE2 1 
ATOM   5564 N N   . LYS C 1 215 ? -45.646  73.722 48.988  1.00 45.24  ? 1065 LYS C N   1 
ATOM   5565 C CA  . LYS C 1 215 ? -44.390  72.999 48.804  1.00 44.99  ? 1065 LYS C CA  1 
ATOM   5566 C C   . LYS C 1 215 ? -44.368  72.113 47.558  1.00 46.57  ? 1065 LYS C C   1 
ATOM   5567 O O   . LYS C 1 215 ? -43.287  71.669 47.150  1.00 46.76  ? 1065 LYS C O   1 
ATOM   5568 C CB  . LYS C 1 215 ? -44.089  72.154 50.048  1.00 42.16  ? 1065 LYS C CB  1 
ATOM   5569 C CG  . LYS C 1 215 ? -44.009  72.971 51.346  1.00 44.74  ? 1065 LYS C CG  1 
ATOM   5570 C CD  . LYS C 1 215 ? -42.584  73.337 51.765  1.00 52.96  ? 1065 LYS C CD  1 
ATOM   5571 C CE  . LYS C 1 215 ? -41.623  72.168 51.626  1.00 50.66  ? 1065 LYS C CE  1 
ATOM   5572 N NZ  . LYS C 1 215 ? -40.420  72.308 52.502  1.00 51.82  ? 1065 LYS C NZ  1 
ATOM   5573 N N   . LEU C 1 216 ? -45.525  71.822 46.970  1.00 39.85  ? 1066 LEU C N   1 
ATOM   5574 C CA  . LEU C 1 216 ? -45.585  71.054 45.734  1.00 43.18  ? 1066 LEU C CA  1 
ATOM   5575 C C   . LEU C 1 216 ? -44.976  71.849 44.581  1.00 44.09  ? 1066 LEU C C   1 
ATOM   5576 O O   . LEU C 1 216 ? -45.033  73.080 44.550  1.00 49.68  ? 1066 LEU C O   1 
ATOM   5577 C CB  . LEU C 1 216 ? -47.034  70.699 45.408  1.00 45.85  ? 1066 LEU C CB  1 
ATOM   5578 C CG  . LEU C 1 216 ? -47.714  69.641 46.276  1.00 45.09  ? 1066 LEU C CG  1 
ATOM   5579 C CD1 . LEU C 1 216 ? -49.182  69.568 45.907  1.00 46.58  ? 1066 LEU C CD1 1 
ATOM   5580 C CD2 . LEU C 1 216 ? -47.051  68.282 46.119  1.00 39.18  ? 1066 LEU C CD2 1 
ATOM   5581 N N   . TYR C 1 217 ? -44.413  71.122 43.633  1.00 46.66  ? 1067 TYR C N   1 
ATOM   5582 C CA  . TYR C 1 217 ? -43.827  71.752 42.428  1.00 51.01  ? 1067 TYR C CA  1 
ATOM   5583 C C   . TYR C 1 217 ? -44.132  70.834 41.248  1.00 49.63  ? 1067 TYR C C   1 
ATOM   5584 O O   . TYR C 1 217 ? -44.460  69.673 41.454  1.00 49.98  ? 1067 TYR C O   1 
ATOM   5585 C CB  . TYR C 1 217 ? -42.350  72.106 42.625  1.00 46.91  ? 1067 TYR C CB  1 
ATOM   5586 C CG  . TYR C 1 217 ? -41.346  70.998 42.803  1.00 48.71  ? 1067 TYR C CG  1 
ATOM   5587 C CD1 . TYR C 1 217 ? -41.012  70.537 44.063  1.00 47.07  ? 1067 TYR C CD1 1 
ATOM   5588 C CD2 . TYR C 1 217 ? -40.653  70.481 41.724  1.00 50.36  ? 1067 TYR C CD2 1 
ATOM   5589 C CE1 . TYR C 1 217 ? -40.061  69.549 44.243  1.00 48.61  ? 1067 TYR C CE1 1 
ATOM   5590 C CE2 . TYR C 1 217 ? -39.693  69.497 41.885  1.00 50.52  ? 1067 TYR C CE2 1 
ATOM   5591 C CZ  . TYR C 1 217 ? -39.398  69.027 43.150  1.00 51.14  ? 1067 TYR C CZ  1 
ATOM   5592 O OH  . TYR C 1 217 ? -38.453  68.054 43.323  1.00 51.11  ? 1067 TYR C OH  1 
ATOM   5593 N N   . THR C 1 218 ? -44.036  71.373 40.036  1.00 54.52  ? 1068 THR C N   1 
ATOM   5594 C CA  . THR C 1 218 ? -44.429  70.598 38.837  1.00 52.44  ? 1068 THR C CA  1 
ATOM   5595 C C   . THR C 1 218 ? -43.219  70.329 37.949  1.00 60.05  ? 1068 THR C C   1 
ATOM   5596 O O   . THR C 1 218 ? -42.358  71.194 37.852  1.00 62.77  ? 1068 THR C O   1 
ATOM   5597 C CB  . THR C 1 218 ? -45.546  71.324 38.078  1.00 58.38  ? 1068 THR C CB  1 
ATOM   5598 O OG1 . THR C 1 218 ? -46.582  71.663 38.998  1.00 58.90  ? 1068 THR C OG1 1 
ATOM   5599 C CG2 . THR C 1 218 ? -46.118  70.499 36.948  1.00 59.11  ? 1068 THR C CG2 1 
ATOM   5600 N N   . LEU C 1 219 ? -43.172  69.150 37.360  1.00 57.78  ? 1069 LEU C N   1 
ATOM   5601 C CA  . LEU C 1 219 ? -42.074  68.787 36.446  1.00 64.30  ? 1069 LEU C CA  1 
ATOM   5602 C C   . LEU C 1 219 ? -42.465  69.197 35.027  1.00 69.68  ? 1069 LEU C C   1 
ATOM   5603 O O   . LEU C 1 219 ? -43.591  69.667 34.835  1.00 65.57  ? 1069 LEU C O   1 
ATOM   5604 C CB  . LEU C 1 219 ? -41.884  67.274 36.503  1.00 67.15  ? 1069 LEU C CB  1 
ATOM   5605 C CG  . LEU C 1 219 ? -41.474  66.697 37.856  1.00 65.05  ? 1069 LEU C CG  1 
ATOM   5606 C CD1 . LEU C 1 219 ? -41.104  65.231 37.715  1.00 57.42  ? 1069 LEU C CD1 1 
ATOM   5607 C CD2 . LEU C 1 219 ? -40.316  67.480 38.449  1.00 58.45  ? 1069 LEU C CD2 1 
ATOM   5608 N N   . GLN C 1 220 ? -41.563  68.981 34.073  1.00 71.67  ? 1070 GLN C N   1 
ATOM   5609 C CA  . GLN C 1 220 ? -41.840  69.328 32.660  1.00 74.42  ? 1070 GLN C CA  1 
ATOM   5610 C C   . GLN C 1 220 ? -43.006  68.481 32.158  1.00 73.50  ? 1070 GLN C C   1 
ATOM   5611 O O   . GLN C 1 220 ? -43.736  68.956 31.291  1.00 77.41  ? 1070 GLN C O   1 
ATOM   5612 C CB  . GLN C 1 220 ? -40.588  69.079 31.824  1.00 77.00  ? 1070 GLN C CB  1 
ATOM   5613 C CG  . GLN C 1 220 ? -40.169  67.612 31.769  1.00 83.65  ? 1070 GLN C CG  1 
ATOM   5614 C CD  . GLN C 1 220 ? -40.024  66.937 33.115  1.00 84.41  ? 1070 GLN C CD  1 
ATOM   5615 O OE1 . GLN C 1 220 ? -39.267  67.373 33.980  1.00 82.23  ? 1070 GLN C OE1 1 
ATOM   5616 N NE2 . GLN C 1 220 ? -40.759  65.853 33.305  1.00 78.21  ? 1070 GLN C NE2 1 
ATOM   5617 N N   . ASP C 1 221 ? -43.172  67.278 32.700  1.00 71.75  ? 1071 ASP C N   1 
ATOM   5618 C CA  . ASP C 1 221 ? -44.240  66.369 32.218  1.00 68.76  ? 1071 ASP C CA  1 
ATOM   5619 C C   . ASP C 1 221 ? -45.542  66.671 32.963  1.00 64.25  ? 1071 ASP C C   1 
ATOM   5620 O O   . ASP C 1 221 ? -46.467  65.884 32.817  1.00 66.37  ? 1071 ASP C O   1 
ATOM   5621 C CB  . ASP C 1 221 ? -43.816  64.910 32.345  1.00 70.66  ? 1071 ASP C CB  1 
ATOM   5622 C CG  . ASP C 1 221 ? -43.527  64.492 33.776  1.00 72.85  ? 1071 ASP C CG  1 
ATOM   5623 O OD1 . ASP C 1 221 ? -43.587  65.361 34.662  1.00 67.06  ? 1071 ASP C OD1 1 
ATOM   5624 O OD2 . ASP C 1 221 ? -43.256  63.299 33.990  1.00 73.65  ? 1071 ASP C OD2 1 
ATOM   5625 N N   . LYS C 1 222 ? -45.577  67.747 33.746  1.00 61.56  ? 1072 LYS C N   1 
ATOM   5626 C CA  . LYS C 1 222 ? -46.826  68.195 34.419  1.00 63.14  ? 1072 LYS C CA  1 
ATOM   5627 C C   . LYS C 1 222 ? -47.072  67.415 35.718  1.00 61.75  ? 1072 LYS C C   1 
ATOM   5628 O O   . LYS C 1 222 ? -48.009  67.765 36.436  1.00 55.99  ? 1072 LYS C O   1 
ATOM   5629 C CB  . LYS C 1 222 ? -48.009  68.101 33.453  1.00 62.04  ? 1072 LYS C CB  1 
ATOM   5630 C CG  . LYS C 1 222 ? -48.161  69.264 32.483  1.00 69.53  ? 1072 LYS C CG  1 
ATOM   5631 C CD  . LYS C 1 222 ? -46.859  69.698 31.848  1.00 72.24  ? 1072 LYS C CD  1 
ATOM   5632 C CE  . LYS C 1 222 ? -47.046  70.584 30.634  1.00 74.98  ? 1072 LYS C CE  1 
ATOM   5633 N NZ  . LYS C 1 222 ? -47.597  69.828 29.486  1.00 72.36  ? 1072 LYS C NZ  1 
ATOM   5634 N N   . ALA C 1 223 ? -46.253  66.409 35.991  1.00 56.82  ? 1073 ALA C N   1 
ATOM   5635 C CA  . ALA C 1 223 ? -46.388  65.665 37.259  1.00 57.14  ? 1073 ALA C CA  1 
ATOM   5636 C C   . ALA C 1 223 ? -46.145  66.595 38.439  1.00 56.07  ? 1073 ALA C C   1 
ATOM   5637 O O   . ALA C 1 223 ? -45.248  67.430 38.349  1.00 51.58  ? 1073 ALA C O   1 
ATOM   5638 C CB  . ALA C 1 223 ? -45.434  64.519 37.295  1.00 54.79  ? 1073 ALA C CB  1 
ATOM   5639 N N   . GLN C 1 224 ? -46.929  66.429 39.507  1.00 50.69  ? 1074 GLN C N   1 
ATOM   5640 C CA  . GLN C 1 224 ? -46.715  67.218 40.742  1.00 47.68  ? 1074 GLN C CA  1 
ATOM   5641 C C   . GLN C 1 224 ? -45.883  66.372 41.715  1.00 41.54  ? 1074 GLN C C   1 
ATOM   5642 O O   . GLN C 1 224 ? -46.128  65.178 41.787  1.00 43.70  ? 1074 GLN C O   1 
ATOM   5643 C CB  . GLN C 1 224 ? -48.050  67.638 41.342  1.00 52.09  ? 1074 GLN C CB  1 
ATOM   5644 C CG  . GLN C 1 224 ? -48.747  68.802 40.665  1.00 52.57  ? 1074 GLN C CG  1 
ATOM   5645 C CD  . GLN C 1 224 ? -50.091  69.015 41.318  1.00 53.01  ? 1074 GLN C CD  1 
ATOM   5646 O OE1 . GLN C 1 224 ? -50.983  68.178 41.231  1.00 56.94  ? 1074 GLN C OE1 1 
ATOM   5647 N NE2 . GLN C 1 224 ? -50.242  70.141 41.993  1.00 57.13  ? 1074 GLN C NE2 1 
ATOM   5648 N N   . VAL C 1 225 ? -44.934  66.992 42.406  1.00 44.50  ? 1075 VAL C N   1 
ATOM   5649 C CA  . VAL C 1 225 ? -44.017  66.263 43.270  1.00 42.32  ? 1075 VAL C CA  1 
ATOM   5650 C C   . VAL C 1 225 ? -43.718  67.085 44.515  1.00 43.75  ? 1075 VAL C C   1 
ATOM   5651 O O   . VAL C 1 225 ? -43.857  68.309 44.536  1.00 44.76  ? 1075 VAL C O   1 
ATOM   5652 C CB  . VAL C 1 225 ? -42.688  65.927 42.556  1.00 49.87  ? 1075 VAL C CB  1 
ATOM   5653 C CG1 . VAL C 1 225 ? -42.914  64.953 41.426  1.00 46.91  ? 1075 VAL C CG1 1 
ATOM   5654 C CG2 . VAL C 1 225 ? -42.036  67.189 42.047  1.00 45.36  ? 1075 VAL C CG2 1 
ATOM   5655 N N   . ALA C 1 226 ? -43.249  66.387 45.543  1.00 40.53  ? 1076 ALA C N   1 
ATOM   5656 C CA  . ALA C 1 226 ? -42.718  66.999 46.750  1.00 36.85  ? 1076 ALA C CA  1 
ATOM   5657 C C   . ALA C 1 226 ? -41.397  66.330 47.089  1.00 33.39  ? 1076 ALA C C   1 
ATOM   5658 O O   . ALA C 1 226 ? -41.234  65.126 46.895  1.00 36.69  ? 1076 ALA C O   1 
ATOM   5659 C CB  . ALA C 1 226 ? -43.690  66.869 47.933  1.00 37.99  ? 1076 ALA C CB  1 
ATOM   5660 N N   . ASP C 1 227 ? -40.445  67.118 47.569  1.00 37.54  ? 1077 ASP C N   1 
ATOM   5661 C CA  . ASP C 1 227 ? -39.178  66.573 48.034  1.00 37.95  ? 1077 ASP C CA  1 
ATOM   5662 C C   . ASP C 1 227 ? -39.354  65.956 49.415  1.00 35.74  ? 1077 ASP C C   1 
ATOM   5663 O O   . ASP C 1 227 ? -40.072  66.497 50.260  1.00 37.18  ? 1077 ASP C O   1 
ATOM   5664 C CB  . ASP C 1 227 ? -38.121  67.673 48.078  1.00 40.72  ? 1077 ASP C CB  1 
ATOM   5665 C CG  . ASP C 1 227 ? -37.669  68.099 46.697  1.00 38.77  ? 1077 ASP C CG  1 
ATOM   5666 O OD1 . ASP C 1 227 ? -37.920  67.358 45.722  1.00 43.13  ? 1077 ASP C OD1 1 
ATOM   5667 O OD2 . ASP C 1 227 ? -37.087  69.197 46.586  1.00 42.90  ? 1077 ASP C OD2 1 
ATOM   5668 N N   . VAL C 1 228 ? -38.696  64.821 49.649  1.00 41.53  ? 1078 VAL C N   1 
ATOM   5669 C CA  . VAL C 1 228 ? -38.758  64.143 50.939  1.00 42.20  ? 1078 VAL C CA  1 
ATOM   5670 C C   . VAL C 1 228 ? -37.357  64.061 51.533  1.00 43.33  ? 1078 VAL C C   1 
ATOM   5671 O O   . VAL C 1 228 ? -36.378  63.840 50.809  1.00 39.81  ? 1078 VAL C O   1 
ATOM   5672 C CB  . VAL C 1 228 ? -39.388  62.735 50.820  1.00 33.45  ? 1078 VAL C CB  1 
ATOM   5673 C CG1 . VAL C 1 228 ? -38.633  61.882 49.812  1.00 37.49  ? 1078 VAL C CG1 1 
ATOM   5674 C CG2 . VAL C 1 228 ? -39.461  62.042 52.183  1.00 36.87  ? 1078 VAL C CG2 1 
ATOM   5675 N N   . VAL C 1 229 ? -37.276  64.227 52.857  1.00 36.43  ? 1079 VAL C N   1 
ATOM   5676 C CA  . VAL C 1 229 ? -36.042  64.053 53.621  1.00 37.43  ? 1079 VAL C CA  1 
ATOM   5677 C C   . VAL C 1 229 ? -36.333  63.064 54.746  1.00 42.81  ? 1079 VAL C C   1 
ATOM   5678 O O   . VAL C 1 229 ? -37.378  63.152 55.403  1.00 40.14  ? 1079 VAL C O   1 
ATOM   5679 C CB  . VAL C 1 229 ? -35.508  65.389 54.179  1.00 42.85  ? 1079 VAL C CB  1 
ATOM   5680 C CG1 . VAL C 1 229 ? -34.509  65.158 55.313  1.00 40.93  ? 1079 VAL C CG1 1 
ATOM   5681 C CG2 . VAL C 1 229 ? -34.866  66.210 53.068  1.00 48.52  ? 1079 VAL C CG2 1 
ATOM   5682 N N   . VAL C 1 230 ? -35.399  62.153 54.981  1.00 36.30  ? 1080 VAL C N   1 
ATOM   5683 C CA  . VAL C 1 230 ? -35.528  61.133 56.053  1.00 36.25  ? 1080 VAL C CA  1 
ATOM   5684 C C   . VAL C 1 230 ? -34.316  61.211 56.986  1.00 43.01  ? 1080 VAL C C   1 
ATOM   5685 O O   . VAL C 1 230 ? -33.213  60.981 56.497  1.00 43.47  ? 1080 VAL C O   1 
ATOM   5686 C CB  . VAL C 1 230 ? -35.619  59.728 55.451  1.00 37.18  ? 1080 VAL C CB  1 
ATOM   5687 C CG1 . VAL C 1 230 ? -35.456  58.654 56.508  1.00 41.29  ? 1080 VAL C CG1 1 
ATOM   5688 C CG2 . VAL C 1 230 ? -36.889  59.514 54.650  1.00 43.06  ? 1080 VAL C CG2 1 
ATOM   5689 N N   . SER C 1 231 ? -34.522  61.527 58.259  1.00 36.91  ? 1081 SER C N   1 
ATOM   5690 C CA  . SER C 1 231 ? -33.426  61.505 59.262  1.00 42.74  ? 1081 SER C CA  1 
ATOM   5691 C C   . SER C 1 231 ? -33.715  60.448 60.333  1.00 35.82  ? 1081 SER C C   1 
ATOM   5692 O O   . SER C 1 231 ? -34.399  60.749 61.288  1.00 38.43  ? 1081 SER C O   1 
ATOM   5693 C CB  . SER C 1 231 ? -33.203  62.826 59.896  1.00 42.18  ? 1081 SER C CB  1 
ATOM   5694 O OG  . SER C 1 231 ? -32.219  62.721 60.908  1.00 47.23  ? 1081 SER C OG  1 
ATOM   5695 N N   . ARG C 1 232 ? -33.169  59.263 60.131  1.00 40.13  ? 1082 ARG C N   1 
ATOM   5696 C CA  . ARG C 1 232 ? -33.339  58.166 61.105  1.00 47.46  ? 1082 ARG C CA  1 
ATOM   5697 C C   . ARG C 1 232 ? -32.798  58.621 62.454  1.00 48.95  ? 1082 ARG C C   1 
ATOM   5698 O O   . ARG C 1 232 ? -33.436  58.351 63.456  1.00 47.23  ? 1082 ARG C O   1 
ATOM   5699 C CB  . ARG C 1 232 ? -32.625  56.920 60.589  1.00 48.29  ? 1082 ARG C CB  1 
ATOM   5700 C CG  . ARG C 1 232 ? -32.742  55.719 61.516  1.00 60.88  ? 1082 ARG C CG  1 
ATOM   5701 C CD  . ARG C 1 232 ? -32.398  54.414 60.825  1.00 69.20  ? 1082 ARG C CD  1 
ATOM   5702 N NE  . ARG C 1 232 ? -31.005  54.346 60.414  1.00 74.17  ? 1082 ARG C NE  1 
ATOM   5703 C CZ  . ARG C 1 232 ? -30.594  54.328 59.152  1.00 77.21  ? 1082 ARG C CZ  1 
ATOM   5704 N NH1 . ARG C 1 232 ? -31.456  54.543 58.172  1.00 72.41  ? 1082 ARG C NH1 1 
ATOM   5705 N NH2 . ARG C 1 232 ? -29.321  54.109 58.875  1.00 73.54  ? 1082 ARG C NH2 1 
ATOM   5706 N N   . TRP C 1 233 ? -31.673  59.321 62.446  1.00 45.00  ? 1083 TRP C N   1 
ATOM   5707 C CA  . TRP C 1 233 ? -31.056  59.814 63.696  1.00 43.59  ? 1083 TRP C CA  1 
ATOM   5708 C C   . TRP C 1 233 ? -32.057  60.684 64.450  1.00 43.43  ? 1083 TRP C C   1 
ATOM   5709 O O   . TRP C 1 233 ? -32.150  60.533 65.659  1.00 43.65  ? 1083 TRP C O   1 
ATOM   5710 C CB  . TRP C 1 233 ? -29.778  60.601 63.376  1.00 44.27  ? 1083 TRP C CB  1 
ATOM   5711 C CG  . TRP C 1 233 ? -29.044  61.131 64.563  1.00 42.46  ? 1083 TRP C CG  1 
ATOM   5712 C CD1 . TRP C 1 233 ? -29.034  62.414 65.023  1.00 40.50  ? 1083 TRP C CD1 1 
ATOM   5713 C CD2 . TRP C 1 233 ? -28.164  60.389 65.418  1.00 40.08  ? 1083 TRP C CD2 1 
ATOM   5714 N NE1 . TRP C 1 233 ? -28.235  62.512 66.126  1.00 44.38  ? 1083 TRP C NE1 1 
ATOM   5715 C CE2 . TRP C 1 233 ? -27.686  61.287 66.390  1.00 41.02  ? 1083 TRP C CE2 1 
ATOM   5716 C CE3 . TRP C 1 233 ? -27.751  59.056 65.462  1.00 41.93  ? 1083 TRP C CE3 1 
ATOM   5717 C CZ2 . TRP C 1 233 ? -26.814  60.887 67.397  1.00 44.67  ? 1083 TRP C CZ2 1 
ATOM   5718 C CZ3 . TRP C 1 233 ? -26.889  58.662 66.459  1.00 47.36  ? 1083 TRP C CZ3 1 
ATOM   5719 C CH2 . TRP C 1 233 ? -26.428  59.568 67.410  1.00 43.98  ? 1083 TRP C CH2 1 
ATOM   5720 N N   . LEU C 1 234 ? -32.723  61.595 63.744  1.00 39.84  ? 1084 LEU C N   1 
ATOM   5721 C CA  . LEU C 1 234 ? -33.708  62.507 64.379  1.00 37.33  ? 1084 LEU C CA  1 
ATOM   5722 C C   . LEU C 1 234 ? -35.106  61.871 64.433  1.00 34.84  ? 1084 LEU C C   1 
ATOM   5723 O O   . LEU C 1 234 ? -35.987  62.477 65.012  1.00 39.05  ? 1084 LEU C O   1 
ATOM   5724 C CB  . LEU C 1 234 ? -33.753  63.793 63.569  1.00 40.33  ? 1084 LEU C CB  1 
ATOM   5725 C CG  . LEU C 1 234 ? -32.462  64.602 63.533  1.00 48.52  ? 1084 LEU C CG  1 
ATOM   5726 C CD1 . LEU C 1 234 ? -32.564  65.702 62.493  1.00 44.81  ? 1084 LEU C CD1 1 
ATOM   5727 C CD2 . LEU C 1 234 ? -32.174  65.192 64.902  1.00 44.48  ? 1084 LEU C CD2 1 
ATOM   5728 N N   . ARG C 1 235 ? -35.258  60.703 63.842  1.00 35.36  ? 1085 ARG C N   1 
ATOM   5729 C CA  . ARG C 1 235 ? -36.571  60.009 63.809  1.00 39.89  ? 1085 ARG C CA  1 
ATOM   5730 C C   . ARG C 1 235 ? -37.591  60.929 63.140  1.00 41.84  ? 1085 ARG C C   1 
ATOM   5731 O O   . ARG C 1 235 ? -38.665  61.123 63.690  1.00 38.39  ? 1085 ARG C O   1 
ATOM   5732 C CB  . ARG C 1 235 ? -36.994  59.611 65.222  1.00 40.91  ? 1085 ARG C CB  1 
ATOM   5733 C CG  . ARG C 1 235 ? -36.205  58.460 65.825  1.00 48.95  ? 1085 ARG C CG  1 
ATOM   5734 C CD  . ARG C 1 235 ? -34.800  58.855 66.226  1.00 57.21  ? 1085 ARG C CD  1 
ATOM   5735 N NE  . ARG C 1 235 ? -34.264  58.000 67.271  1.00 65.70  ? 1085 ARG C NE  1 
ATOM   5736 C CZ  . ARG C 1 235 ? -33.212  57.208 67.130  1.00 62.64  ? 1085 ARG C CZ  1 
ATOM   5737 N NH1 . ARG C 1 235 ? -32.761  56.917 65.924  1.00 53.41  ? 1085 ARG C NH1 1 
ATOM   5738 N NH2 . ARG C 1 235 ? -32.627  56.697 68.198  1.00 64.38  ? 1085 ARG C NH2 1 
ATOM   5739 N N   . VAL C 1 236 ? -37.220  61.470 61.991  1.00 36.88  ? 1086 VAL C N   1 
ATOM   5740 C CA  . VAL C 1 236 ? -38.137  62.389 61.279  1.00 41.42  ? 1086 VAL C CA  1 
ATOM   5741 C C   . VAL C 1 236 ? -38.134  62.134 59.776  1.00 44.00  ? 1086 VAL C C   1 
ATOM   5742 O O   . VAL C 1 236 ? -37.056  61.978 59.221  1.00 39.10  ? 1086 VAL C O   1 
ATOM   5743 C CB  . VAL C 1 236 ? -37.823  63.865 61.586  1.00 47.33  ? 1086 VAL C CB  1 
ATOM   5744 C CG1 . VAL C 1 236 ? -38.385  64.791 60.524  1.00 46.18  ? 1086 VAL C CG1 1 
ATOM   5745 C CG2 . VAL C 1 236 ? -38.294  64.281 62.967  1.00 43.35  ? 1086 VAL C CG2 1 
ATOM   5746 N N   . THR C 1 237 ? -39.313  61.981 59.182  1.00 37.30  ? 1087 THR C N   1 
ATOM   5747 C CA  . THR C 1 237 ? -39.478  61.945 57.731  1.00 35.58  ? 1087 THR C CA  1 
ATOM   5748 C C   . THR C 1 237 ? -40.433  63.067 57.365  1.00 42.00  ? 1087 THR C C   1 
ATOM   5749 O O   . THR C 1 237 ? -41.528  63.165 57.929  1.00 33.28  ? 1087 THR C O   1 
ATOM   5750 C CB  . THR C 1 237 ? -40.020  60.600 57.228  1.00 38.21  ? 1087 THR C CB  1 
ATOM   5751 O OG1 . THR C 1 237 ? -39.100  59.551 57.551  1.00 40.50  ? 1087 THR C OG1 1 
ATOM   5752 C CG2 . THR C 1 237 ? -40.225  60.639 55.713  1.00 40.11  ? 1087 THR C CG2 1 
ATOM   5753 N N   . VAL C 1 238 ? -40.016  63.935 56.453  1.00 34.14  ? 1088 VAL C N   1 
ATOM   5754 C CA  . VAL C 1 238 ? -40.806  65.120 56.151  1.00 33.59  ? 1088 VAL C CA  1 
ATOM   5755 C C   . VAL C 1 238 ? -40.879  65.321 54.643  1.00 40.93  ? 1088 VAL C C   1 
ATOM   5756 O O   . VAL C 1 238 ? -39.885  65.140 53.927  1.00 37.73  ? 1088 VAL C O   1 
ATOM   5757 C CB  . VAL C 1 238 ? -40.236  66.344 56.899  1.00 40.46  ? 1088 VAL C CB  1 
ATOM   5758 C CG1 . VAL C 1 238 ? -38.765  66.532 56.579  1.00 46.34  ? 1088 VAL C CG1 1 
ATOM   5759 C CG2 . VAL C 1 238 ? -41.060  67.596 56.638  1.00 36.68  ? 1088 VAL C CG2 1 
ATOM   5760 N N   . ALA C 1 239 ? -42.074  65.672 54.162  1.00 37.04  ? 1089 ALA C N   1 
ATOM   5761 C CA  . ALA C 1 239 ? -42.283  65.912 52.739  1.00 33.03  ? 1089 ALA C CA  1 
ATOM   5762 C C   . ALA C 1 239 ? -43.572  66.698 52.560  1.00 41.35  ? 1089 ALA C C   1 
ATOM   5763 O O   . ALA C 1 239 ? -44.574  66.403 53.218  1.00 35.80  ? 1089 ALA C O   1 
ATOM   5764 C CB  . ALA C 1 239 ? -42.343  64.601 51.948  1.00 32.32  ? 1089 ALA C CB  1 
ATOM   5765 N N   . GLY C 1 240 ? -43.530  67.711 51.696  1.00 40.46  ? 1090 GLY C N   1 
ATOM   5766 C CA  . GLY C 1 240 ? -44.698  68.556 51.513  1.00 35.99  ? 1090 GLY C CA  1 
ATOM   5767 C C   . GLY C 1 240 ? -45.133  69.142 52.840  1.00 38.49  ? 1090 GLY C C   1 
ATOM   5768 O O   . GLY C 1 240 ? -44.318  69.652 53.616  1.00 38.47  ? 1090 GLY C O   1 
ATOM   5769 N N   . GLY C 1 241 ? -46.430  69.052 53.119  1.00 36.59  ? 1091 GLY C N   1 
ATOM   5770 C CA  . GLY C 1 241 ? -46.966  69.492 54.390  1.00 33.71  ? 1091 GLY C CA  1 
ATOM   5771 C C   . GLY C 1 241 ? -47.244  68.350 55.345  1.00 39.37  ? 1091 GLY C C   1 
ATOM   5772 O O   . GLY C 1 241 ? -48.201  68.412 56.125  1.00 36.11  ? 1091 GLY C O   1 
ATOM   5773 N N   . VAL C 1 242 ? -46.416  67.306 55.303  1.00 33.85  ? 1092 VAL C N   1 
ATOM   5774 C CA  . VAL C 1 242 ? -46.539  66.158 56.196  1.00 33.30  ? 1092 VAL C CA  1 
ATOM   5775 C C   . VAL C 1 242 ? -45.229  65.985 56.954  1.00 37.48  ? 1092 VAL C C   1 
ATOM   5776 O O   . VAL C 1 242 ? -44.148  65.943 56.345  1.00 35.23  ? 1092 VAL C O   1 
ATOM   5777 C CB  . VAL C 1 242 ? -46.892  64.867 55.434  1.00 32.61  ? 1092 VAL C CB  1 
ATOM   5778 C CG1 . VAL C 1 242 ? -47.134  63.721 56.416  1.00 31.43  ? 1092 VAL C CG1 1 
ATOM   5779 C CG2 . VAL C 1 242 ? -48.100  65.079 54.533  1.00 36.27  ? 1092 VAL C CG2 1 
ATOM   5780 N N   . HIS C 1 243 ? -45.337  65.857 58.279  1.00 34.26  ? 1093 HIS C N   1 
ATOM   5781 C CA  . HIS C 1 243 ? -44.201  65.674 59.177  1.00 31.67  ? 1093 HIS C CA  1 
ATOM   5782 C C   . HIS C 1 243 ? -44.475  64.446 60.033  1.00 35.40  ? 1093 HIS C C   1 
ATOM   5783 O O   . HIS C 1 243 ? -45.458  64.422 60.782  1.00 34.83  ? 1093 HIS C O   1 
ATOM   5784 C CB  . HIS C 1 243 ? -43.989  66.916 60.056  1.00 32.35  ? 1093 HIS C CB  1 
ATOM   5785 C CG  . HIS C 1 243 ? -42.761  66.860 60.913  1.00 40.57  ? 1093 HIS C CG  1 
ATOM   5786 N ND1 . HIS C 1 243 ? -42.703  66.147 62.091  1.00 37.35  ? 1093 HIS C ND1 1 
ATOM   5787 C CD2 . HIS C 1 243 ? -41.544  67.437 60.763  1.00 39.53  ? 1093 HIS C CD2 1 
ATOM   5788 C CE1 . HIS C 1 243 ? -41.503  66.284 62.628  1.00 45.17  ? 1093 HIS C CE1 1 
ATOM   5789 N NE2 . HIS C 1 243 ? -40.781  67.061 61.842  1.00 41.77  ? 1093 HIS C NE2 1 
ATOM   5790 N N   . ILE C 1 244 ? -43.633  63.419 59.904  1.00 32.15  ? 1094 ILE C N   1 
ATOM   5791 C CA  . ILE C 1 244 ? -43.780  62.162 60.631  1.00 28.62  ? 1094 ILE C CA  1 
ATOM   5792 C C   . ILE C 1 244 ? -42.609  62.043 61.594  1.00 36.90  ? 1094 ILE C C   1 
ATOM   5793 O O   . ILE C 1 244 ? -41.444  62.082 61.174  1.00 34.79  ? 1094 ILE C O   1 
ATOM   5794 C CB  . ILE C 1 244 ? -43.827  60.954 59.684  1.00 30.47  ? 1094 ILE C CB  1 
ATOM   5795 C CG1 . ILE C 1 244 ? -45.027  61.048 58.744  1.00 32.49  ? 1094 ILE C CG1 1 
ATOM   5796 C CG2 . ILE C 1 244 ? -43.856  59.652 60.475  1.00 30.76  ? 1094 ILE C CG2 1 
ATOM   5797 C CD1 . ILE C 1 244 ? -45.002  60.012 57.653  1.00 31.51  ? 1094 ILE C CD1 1 
ATOM   5798 N N   . SER C 1 245 ? -42.913  61.891 62.880  1.00 28.96  ? 1095 SER C N   1 
ATOM   5799 C CA  . SER C 1 245 ? -41.920  61.871 63.941  1.00 27.37  ? 1095 SER C CA  1 
ATOM   5800 C C   . SER C 1 245 ? -42.082  60.612 64.779  1.00 38.37  ? 1095 SER C C   1 
ATOM   5801 O O   . SER C 1 245 ? -43.196  60.287 65.211  1.00 32.42  ? 1095 SER C O   1 
ATOM   5802 C CB  . SER C 1 245 ? -42.058  63.112 64.826  1.00 32.76  ? 1095 SER C CB  1 
ATOM   5803 O OG  . SER C 1 245 ? -41.091  63.113 65.859  1.00 41.16  ? 1095 SER C OG  1 
ATOM   5804 N N   . GLY C 1 246 ? -40.973  59.918 65.015  1.00 33.32  ? 1096 GLY C N   1 
ATOM   5805 C CA  . GLY C 1 246 ? -40.991  58.797 65.938  1.00 33.74  ? 1096 GLY C CA  1 
ATOM   5806 C C   . GLY C 1 246 ? -41.647  57.545 65.402  1.00 36.45  ? 1096 GLY C C   1 
ATOM   5807 O O   . GLY C 1 246 ? -42.414  56.895 66.123  1.00 34.91  ? 1096 GLY C O   1 
ATOM   5808 N N   . LEU C 1 247 ? -41.379  57.212 64.146  1.00 33.85  ? 1097 LEU C N   1 
ATOM   5809 C CA  . LEU C 1 247 ? -41.902  55.954 63.571  1.00 34.41  ? 1097 LEU C CA  1 
ATOM   5810 C C   . LEU C 1 247 ? -41.216  54.753 64.205  1.00 41.28  ? 1097 LEU C C   1 
ATOM   5811 O O   . LEU C 1 247 ? -39.996  54.721 64.206  1.00 38.69  ? 1097 LEU C O   1 
ATOM   5812 C CB  . LEU C 1 247 ? -41.648  55.909 62.070  1.00 32.92  ? 1097 LEU C CB  1 
ATOM   5813 C CG  . LEU C 1 247 ? -41.937  54.577 61.387  1.00 35.40  ? 1097 LEU C CG  1 
ATOM   5814 C CD1 . LEU C 1 247 ? -43.431  54.320 61.333  1.00 35.63  ? 1097 LEU C CD1 1 
ATOM   5815 C CD2 . LEU C 1 247 ? -41.352  54.561 59.987  1.00 40.66  ? 1097 LEU C CD2 1 
ATOM   5816 N N   . HIS C 1 248 ? -42.000  53.805 64.699  1.00 31.88  ? 1098 HIS C N   1 
ATOM   5817 C CA  . HIS C 1 248 ? -41.437  52.545 65.226  1.00 37.28  ? 1098 HIS C CA  1 
ATOM   5818 C C   . HIS C 1 248 ? -41.936  51.414 64.331  1.00 38.43  ? 1098 HIS C C   1 
ATOM   5819 O O   . HIS C 1 248 ? -43.105  51.422 63.941  1.00 34.47  ? 1098 HIS C O   1 
ATOM   5820 C CB  . HIS C 1 248 ? -41.845  52.290 66.678  1.00 36.96  ? 1098 HIS C CB  1 
ATOM   5821 C CG  . HIS C 1 248 ? -41.510  53.338 67.672  1.00 41.39  ? 1098 HIS C CG  1 
ATOM   5822 N ND1 . HIS C 1 248 ? -41.952  54.637 67.583  1.00 39.59  ? 1098 HIS C ND1 1 
ATOM   5823 C CD2 . HIS C 1 248 ? -40.803  53.263 68.799  1.00 44.42  ? 1098 HIS C CD2 1 
ATOM   5824 C CE1 . HIS C 1 248 ? -41.507  55.316 68.623  1.00 41.61  ? 1098 HIS C CE1 1 
ATOM   5825 N NE2 . HIS C 1 248 ? -40.806  54.503 69.372  1.00 47.29  ? 1098 HIS C NE2 1 
ATOM   5826 N N   . THR C 1 249 ? -41.056  50.480 64.008  1.00 33.39  ? 1099 THR C N   1 
ATOM   5827 C CA  . THR C 1 249 ? -41.408  49.337 63.148  1.00 33.57  ? 1099 THR C CA  1 
ATOM   5828 C C   . THR C 1 249 ? -41.052  48.048 63.868  1.00 42.49  ? 1099 THR C C   1 
ATOM   5829 O O   . THR C 1 249 ? -40.296  48.106 64.832  1.00 43.82  ? 1099 THR C O   1 
ATOM   5830 C CB  . THR C 1 249 ? -40.671  49.403 61.805  1.00 46.75  ? 1099 THR C CB  1 
ATOM   5831 O OG1 . THR C 1 249 ? -39.264  49.384 62.036  1.00 43.85  ? 1099 THR C OG1 1 
ATOM   5832 C CG2 . THR C 1 249 ? -41.054  50.623 60.997  1.00 42.75  ? 1099 THR C CG2 1 
ATOM   5833 N N   . GLU C 1 250 ? -41.604  46.944 63.409  1.00 39.76  ? 1100 GLU C N   1 
ATOM   5834 C CA  . GLU C 1 250 ? -41.236  45.637 63.992  1.00 44.85  ? 1100 GLU C CA  1 
ATOM   5835 C C   . GLU C 1 250 ? -41.253  44.599 62.885  1.00 49.03  ? 1100 GLU C C   1 
ATOM   5836 O O   . GLU C 1 250 ? -41.934  44.806 61.888  1.00 47.73  ? 1100 GLU C O   1 
ATOM   5837 C CB  . GLU C 1 250 ? -42.141  45.241 65.153  1.00 42.88  ? 1100 GLU C CB  1 
ATOM   5838 C CG  . GLU C 1 250 ? -42.369  46.372 66.143  1.00 52.10  ? 1100 GLU C CG  1 
ATOM   5839 C CD  . GLU C 1 250 ? -41.418  46.479 67.324  1.00 64.95  ? 1100 GLU C CD  1 
ATOM   5840 O OE1 . GLU C 1 250 ? -40.197  46.417 67.109  1.00 70.35  ? 1100 GLU C OE1 1 
ATOM   5841 O OE2 . GLU C 1 250 ? -41.907  46.610 68.462  1.00 65.05  ? 1100 GLU C OE2 1 
ATOM   5842 N N   . SER C 1 251 ? -40.495  43.539 63.082  1.00 50.34  ? 1101 SER C N   1 
ATOM   5843 C CA  . SER C 1 251 ? -40.404  42.458 62.084  1.00 54.49  ? 1101 SER C CA  1 
ATOM   5844 C C   . SER C 1 251 ? -41.747  41.760 61.948  1.00 53.71  ? 1101 SER C C   1 
ATOM   5845 O O   . SER C 1 251 ? -42.462  41.672 62.943  1.00 54.40  ? 1101 SER C O   1 
ATOM   5846 C CB  . SER C 1 251 ? -39.334  41.480 62.474  1.00 53.54  ? 1101 SER C CB  1 
ATOM   5847 O OG  . SER C 1 251 ? -39.365  41.238 63.868  1.00 63.67  ? 1101 SER C OG  1 
ATOM   5848 N N   . ALA C 1 252 ? -42.042  41.290 60.744  1.00 58.01  ? 1102 ALA C N   1 
ATOM   5849 C CA  . ALA C 1 252 ? -43.284  40.529 60.502  1.00 60.15  ? 1102 ALA C CA  1 
ATOM   5850 C C   . ALA C 1 252 ? -43.105  39.605 59.298  1.00 59.12  ? 1102 ALA C C   1 
ATOM   5851 O O   . ALA C 1 252 ? -41.953  39.261 59.020  1.00 66.06  ? 1102 ALA C O   1 
ATOM   5852 C CB  . ALA C 1 252 ? -44.396  41.484 60.265  1.00 60.19  ? 1102 ALA C CB  1 
ATOM   5853 N N   . SER D 1 1   ? -65.087  54.957 49.476  1.00 50.22  ? -7   SER D N   1 
ATOM   5854 C CA  . SER D 1 1   ? -65.764  54.272 50.572  1.00 42.25  ? -7   SER D CA  1 
ATOM   5855 C C   . SER D 1 1   ? -67.182  54.790 50.768  1.00 45.03  ? -7   SER D C   1 
ATOM   5856 O O   . SER D 1 1   ? -67.461  55.953 50.495  1.00 44.52  ? -7   SER D O   1 
ATOM   5857 C CB  . SER D 1 1   ? -64.968  54.429 51.872  1.00 45.48  ? -7   SER D CB  1 
ATOM   5858 O OG  . SER D 1 1   ? -64.687  55.785 52.175  1.00 40.69  ? -7   SER D OG  1 
ATOM   5859 N N   . GLU D 1 2   ? -68.084  53.917 51.217  1.00 45.12  ? -6   GLU D N   1 
ATOM   5860 C CA  . GLU D 1 2   ? -69.379  54.348 51.726  1.00 40.71  ? -6   GLU D CA  1 
ATOM   5861 C C   . GLU D 1 2   ? -69.219  54.644 53.210  1.00 40.60  ? -6   GLU D C   1 
ATOM   5862 O O   . GLU D 1 2   ? -68.723  53.799 53.962  1.00 37.90  ? -6   GLU D O   1 
ATOM   5863 C CB  . GLU D 1 2   ? -70.469  53.294 51.535  1.00 46.31  ? -6   GLU D CB  1 
ATOM   5864 C CG  . GLU D 1 2   ? -71.620  53.504 52.523  1.00 54.79  ? -6   GLU D CG  1 
ATOM   5865 C CD  . GLU D 1 2   ? -72.647  52.392 52.520  1.00 57.09  ? -6   GLU D CD  1 
ATOM   5866 O OE1 . GLU D 1 2   ? -72.282  51.242 52.835  1.00 54.86  ? -6   GLU D OE1 1 
ATOM   5867 O OE2 . GLU D 1 2   ? -73.825  52.670 52.217  1.00 61.41  ? -6   GLU D OE2 1 
ATOM   5868 N N   . ASN D 1 3   ? -69.607  55.843 53.625  1.00 33.64  ? -5   ASN D N   1 
ATOM   5869 C CA  . ASN D 1 3   ? -69.349  56.309 54.980  1.00 33.64  ? -5   ASN D CA  1 
ATOM   5870 C C   . ASN D 1 3   ? -70.657  56.423 55.755  1.00 36.32  ? -5   ASN D C   1 
ATOM   5871 O O   . ASN D 1 3   ? -71.627  57.007 55.262  1.00 33.34  ? -5   ASN D O   1 
ATOM   5872 C CB  . ASN D 1 3   ? -68.623  57.653 54.947  1.00 33.83  ? -5   ASN D CB  1 
ATOM   5873 C CG  . ASN D 1 3   ? -67.341  57.600 54.134  1.00 32.15  ? -5   ASN D CG  1 
ATOM   5874 O OD1 . ASN D 1 3   ? -66.873  56.525 53.756  1.00 31.86  ? -5   ASN D OD1 1 
ATOM   5875 N ND2 . ASN D 1 3   ? -66.774  58.765 53.851  1.00 33.69  ? -5   ASN D ND2 1 
ATOM   5876 N N   . LEU D 1 4   ? -70.667  55.885 56.973  1.00 27.10  ? -4   LEU D N   1 
ATOM   5877 C CA  . LEU D 1 4   ? -71.828  55.902 57.854  1.00 29.35  ? -4   LEU D CA  1 
ATOM   5878 C C   . LEU D 1 4   ? -71.447  56.659 59.118  1.00 26.63  ? -4   LEU D C   1 
ATOM   5879 O O   . LEU D 1 4   ? -70.430  56.341 59.740  1.00 29.20  ? -4   LEU D O   1 
ATOM   5880 C CB  . LEU D 1 4   ? -72.265  54.476 58.199  1.00 30.74  ? -4   LEU D CB  1 
ATOM   5881 C CG  . LEU D 1 4   ? -72.506  53.553 57.003  1.00 33.96  ? -4   LEU D CG  1 
ATOM   5882 C CD1 . LEU D 1 4   ? -72.836  52.142 57.464  1.00 36.80  ? -4   LEU D CD1 1 
ATOM   5883 C CD2 . LEU D 1 4   ? -73.613  54.107 56.127  1.00 36.16  ? -4   LEU D CD2 1 
ATOM   5884 N N   . TYR D 1 5   ? -72.249  57.649 59.504  1.00 27.36  ? -3   TYR D N   1 
ATOM   5885 C CA  . TYR D 1 5   ? -71.882  58.532 60.605  1.00 24.60  ? -3   TYR D CA  1 
ATOM   5886 C C   . TYR D 1 5   ? -72.822  58.356 61.792  1.00 30.60  ? -3   TYR D C   1 
ATOM   5887 O O   . TYR D 1 5   ? -74.014  58.085 61.628  1.00 29.10  ? -3   TYR D O   1 
ATOM   5888 C CB  . TYR D 1 5   ? -71.882  59.993 60.153  1.00 28.75  ? -3   TYR D CB  1 
ATOM   5889 C CG  . TYR D 1 5   ? -70.865  60.245 59.069  1.00 29.17  ? -3   TYR D CG  1 
ATOM   5890 C CD1 . TYR D 1 5   ? -69.507  60.288 59.355  1.00 32.11  ? -3   TYR D CD1 1 
ATOM   5891 C CD2 . TYR D 1 5   ? -71.264  60.415 57.752  1.00 32.59  ? -3   TYR D CD2 1 
ATOM   5892 C CE1 . TYR D 1 5   ? -68.574  60.504 58.355  1.00 31.10  ? -3   TYR D CE1 1 
ATOM   5893 C CE2 . TYR D 1 5   ? -70.343  60.633 56.748  1.00 34.41  ? -3   TYR D CE2 1 
ATOM   5894 C CZ  . TYR D 1 5   ? -69.000  60.677 57.053  1.00 38.37  ? -3   TYR D CZ  1 
ATOM   5895 O OH  . TYR D 1 5   ? -68.088  60.894 56.045  1.00 36.83  ? -3   TYR D OH  1 
ATOM   5896 N N   . PHE D 1 6   ? -72.271  58.532 62.994  1.00 24.21  ? -2   PHE D N   1 
ATOM   5897 C CA  . PHE D 1 6   ? -72.994  58.289 64.238  1.00 27.60  ? -2   PHE D CA  1 
ATOM   5898 C C   . PHE D 1 6   ? -72.770  59.437 65.212  1.00 28.03  ? -2   PHE D C   1 
ATOM   5899 O O   . PHE D 1 6   ? -71.631  59.873 65.411  1.00 29.97  ? -2   PHE D O   1 
ATOM   5900 C CB  . PHE D 1 6   ? -72.563  56.953 64.852  1.00 26.66  ? -2   PHE D CB  1 
ATOM   5901 C CG  . PHE D 1 6   ? -72.725  55.795 63.914  1.00 27.91  ? -2   PHE D CG  1 
ATOM   5902 C CD1 . PHE D 1 6   ? -73.937  55.135 63.818  1.00 26.65  ? -2   PHE D CD1 1 
ATOM   5903 C CD2 . PHE D 1 6   ? -71.680  55.391 63.098  1.00 25.69  ? -2   PHE D CD2 1 
ATOM   5904 C CE1 . PHE D 1 6   ? -74.101  54.080 62.942  1.00 29.11  ? -2   PHE D CE1 1 
ATOM   5905 C CE2 . PHE D 1 6   ? -71.837  54.337 62.219  1.00 25.57  ? -2   PHE D CE2 1 
ATOM   5906 C CZ  . PHE D 1 6   ? -73.050  53.680 62.140  1.00 29.30  ? -2   PHE D CZ  1 
ATOM   5907 N N   . GLN D 1 7   ? -73.859  59.928 65.815  1.00 26.60  ? -1   GLN D N   1 
ATOM   5908 C CA  . GLN D 1 7   ? -73.752  61.082 66.704  1.00 28.81  ? -1   GLN D CA  1 
ATOM   5909 C C   . GLN D 1 7   ? -73.124  60.738 68.050  1.00 29.04  ? -1   GLN D C   1 
ATOM   5910 O O   . GLN D 1 7   ? -72.638  61.645 68.734  1.00 29.21  ? -1   GLN D O   1 
ATOM   5911 C CB  . GLN D 1 7   ? -75.126  61.730 66.909  1.00 30.82  ? -1   GLN D CB  1 
ATOM   5912 C CG  . GLN D 1 7   ? -76.252  60.797 67.318  1.00 34.39  ? -1   GLN D CG  1 
ATOM   5913 C CD  . GLN D 1 7   ? -77.528  61.557 67.641  1.00 36.13  ? -1   GLN D CD  1 
ATOM   5914 O OE1 . GLN D 1 7   ? -78.576  61.316 67.043  1.00 35.36  ? -1   GLN D OE1 1 
ATOM   5915 N NE2 . GLN D 1 7   ? -77.443  62.478 68.595  1.00 34.13  ? -1   GLN D NE2 1 
ATOM   5916 N N   . SER D 1 8   ? -73.130  59.468 68.447  1.00 29.97  ? 858  SER D N   1 
ATOM   5917 C CA  . SER D 1 8   ? -72.491  59.011 69.676  1.00 28.88  ? 858  SER D CA  1 
ATOM   5918 C C   . SER D 1 8   ? -72.504  57.489 69.667  1.00 27.94  ? 858  SER D C   1 
ATOM   5919 O O   . SER D 1 8   ? -73.203  56.859 68.864  1.00 28.17  ? 858  SER D O   1 
ATOM   5920 C CB  . SER D 1 8   ? -73.152  59.563 70.950  1.00 33.69  ? 858  SER D CB  1 
ATOM   5921 O OG  . SER D 1 8   ? -74.483  59.113 71.108  1.00 31.44  ? 858  SER D OG  1 
ATOM   5922 N N   . ALA D 1 9   ? -71.691  56.909 70.545  1.00 27.57  ? 859  ALA D N   1 
ATOM   5923 C CA  . ALA D 1 9   ? -71.660  55.466 70.708  1.00 24.65  ? 859  ALA D CA  1 
ATOM   5924 C C   . ALA D 1 9   ? -71.222  55.138 72.126  1.00 22.93  ? 859  ALA D C   1 
ATOM   5925 O O   . ALA D 1 9   ? -70.723  55.992 72.864  1.00 25.36  ? 859  ALA D O   1 
ATOM   5926 C CB  . ALA D 1 9   ? -70.736  54.802 69.680  1.00 26.84  ? 859  ALA D CB  1 
ATOM   5927 N N   . ALA D 1 10  ? -71.442  53.887 72.509  1.00 26.53  ? 860  ALA D N   1 
ATOM   5928 C CA  . ALA D 1 10  ? -71.039  53.419 73.823  1.00 28.05  ? 860  ALA D CA  1 
ATOM   5929 C C   . ALA D 1 10  ? -70.794  51.924 73.742  1.00 28.25  ? 860  ALA D C   1 
ATOM   5930 O O   . ALA D 1 10  ? -71.448  51.216 72.978  1.00 26.69  ? 860  ALA D O   1 
ATOM   5931 C CB  . ALA D 1 10  ? -72.092  53.732 74.893  1.00 26.98  ? 860  ALA D CB  1 
ATOM   5932 N N   . ILE D 1 11  ? -69.843  51.443 74.529  1.00 27.01  ? 861  ILE D N   1 
ATOM   5933 C CA  . ILE D 1 11  ? -69.543  50.021 74.575  1.00 27.87  ? 861  ILE D CA  1 
ATOM   5934 C C   . ILE D 1 11  ? -69.792  49.541 75.994  1.00 32.70  ? 861  ILE D C   1 
ATOM   5935 O O   . ILE D 1 11  ? -69.343  50.170 76.959  1.00 31.68  ? 861  ILE D O   1 
ATOM   5936 C CB  . ILE D 1 11  ? -68.107  49.714 74.110  1.00 28.57  ? 861  ILE D CB  1 
ATOM   5937 C CG1 . ILE D 1 11  ? -67.981  49.975 72.604  1.00 29.38  ? 861  ILE D CG1 1 
ATOM   5938 C CG2 . ILE D 1 11  ? -67.753  48.269 74.414  1.00 29.91  ? 861  ILE D CG2 1 
ATOM   5939 C CD1 . ILE D 1 11  ? -66.574  49.824 72.043  1.00 30.04  ? 861  ILE D CD1 1 
ATOM   5940 N N   . TYR D 1 12  ? -70.546  48.456 76.115  1.00 29.14  ? 862  TYR D N   1 
ATOM   5941 C CA  . TYR D 1 12  ? -70.916  47.866 77.389  1.00 28.59  ? 862  TYR D CA  1 
ATOM   5942 C C   . TYR D 1 12  ? -70.191  46.535 77.488  1.00 31.99  ? 862  TYR D C   1 
ATOM   5943 O O   . TYR D 1 12  ? -70.519  45.583 76.768  1.00 28.78  ? 862  TYR D O   1 
ATOM   5944 C CB  . TYR D 1 12  ? -72.433  47.716 77.492  1.00 31.19  ? 862  TYR D CB  1 
ATOM   5945 C CG  . TYR D 1 12  ? -73.090  49.067 77.415  1.00 28.56  ? 862  TYR D CG  1 
ATOM   5946 C CD1 . TYR D 1 12  ? -73.427  49.639 76.193  1.00 25.89  ? 862  TYR D CD1 1 
ATOM   5947 C CD2 . TYR D 1 12  ? -73.278  49.816 78.562  1.00 26.63  ? 862  TYR D CD2 1 
ATOM   5948 C CE1 . TYR D 1 12  ? -73.990  50.901 76.131  1.00 28.45  ? 862  TYR D CE1 1 
ATOM   5949 C CE2 . TYR D 1 12  ? -73.833  51.071 78.512  1.00 30.09  ? 862  TYR D CE2 1 
ATOM   5950 C CZ  . TYR D 1 12  ? -74.188  51.612 77.298  1.00 29.45  ? 862  TYR D CZ  1 
ATOM   5951 O OH  . TYR D 1 12  ? -74.741  52.870 77.267  1.00 30.38  ? 862  TYR D OH  1 
ATOM   5952 N N   . ASN D 1 13  ? -69.175  46.500 78.344  1.00 31.96  ? 863  ASN D N   1 
ATOM   5953 C CA  . ASN D 1 13  ? -68.398  45.296 78.594  1.00 34.87  ? 863  ASN D CA  1 
ATOM   5954 C C   . ASN D 1 13  ? -69.029  44.625 79.804  1.00 33.74  ? 863  ASN D C   1 
ATOM   5955 O O   . ASN D 1 13  ? -68.919  45.120 80.930  1.00 33.72  ? 863  ASN D O   1 
ATOM   5956 C CB  . ASN D 1 13  ? -66.930  45.642 78.828  1.00 35.99  ? 863  ASN D CB  1 
ATOM   5957 C CG  . ASN D 1 13  ? -66.230  46.084 77.556  1.00 33.14  ? 863  ASN D CG  1 
ATOM   5958 O OD1 . ASN D 1 13  ? -66.457  45.525 76.484  1.00 35.97  ? 863  ASN D OD1 1 
ATOM   5959 N ND2 . ASN D 1 13  ? -65.387  47.105 77.666  1.00 39.16  ? 863  ASN D ND2 1 
ATOM   5960 N N   . ILE D 1 14  ? -69.683  43.504 79.547  1.00 33.16  ? 864  ILE D N   1 
ATOM   5961 C CA  . ILE D 1 14  ? -70.493  42.857 80.604  1.00 36.09  ? 864  ILE D CA  1 
ATOM   5962 C C   . ILE D 1 14  ? -69.836  41.577 81.112  1.00 37.78  ? 864  ILE D C   1 
ATOM   5963 O O   . ILE D 1 14  ? -69.397  40.778 80.292  1.00 39.46  ? 864  ILE D O   1 
ATOM   5964 C CB  . ILE D 1 14  ? -71.917  42.606 80.077  1.00 40.80  ? 864  ILE D CB  1 
ATOM   5965 C CG1 . ILE D 1 14  ? -72.631  43.922 79.767  1.00 38.46  ? 864  ILE D CG1 1 
ATOM   5966 C CG2 . ILE D 1 14  ? -72.711  41.749 81.045  1.00 39.46  ? 864  ILE D CG2 1 
ATOM   5967 C CD1 . ILE D 1 14  ? -73.705  43.810 78.720  1.00 39.22  ? 864  ILE D CD1 1 
ATOM   5968 N N   . ASP D 1 15  ? -69.779  41.458 82.429  1.00 41.75  ? 865  ASP D N   1 
ATOM   5969 C CA  . ASP D 1 15  ? -69.177  40.284 83.098  1.00 41.18  ? 865  ASP D CA  1 
ATOM   5970 C C   . ASP D 1 15  ? -70.265  39.669 83.967  1.00 35.48  ? 865  ASP D C   1 
ATOM   5971 O O   . ASP D 1 15  ? -70.948  40.419 84.637  1.00 39.97  ? 865  ASP D O   1 
ATOM   5972 C CB  . ASP D 1 15  ? -67.914  40.675 83.868  1.00 47.00  ? 865  ASP D CB  1 
ATOM   5973 C CG  . ASP D 1 15  ? -67.536  39.769 85.016  1.00 45.81  ? 865  ASP D CG  1 
ATOM   5974 O OD1 . ASP D 1 15  ? -67.450  38.559 84.799  1.00 50.82  ? 865  ASP D OD1 1 
ATOM   5975 O OD2 . ASP D 1 15  ? -67.291  40.302 86.098  1.00 57.56  ? 865  ASP D OD2 1 
ATOM   5976 N N   . THR D 1 16  ? -70.392  38.352 83.926  1.00 35.53  ? 866  THR D N   1 
ATOM   5977 C CA  . THR D 1 16  ? -71.447  37.616 84.661  1.00 34.92  ? 866  THR D CA  1 
ATOM   5978 C C   . THR D 1 16  ? -70.900  37.067 85.989  1.00 39.65  ? 866  THR D C   1 
ATOM   5979 O O   . THR D 1 16  ? -71.604  36.305 86.617  1.00 39.43  ? 866  THR D O   1 
ATOM   5980 C CB  . THR D 1 16  ? -72.030  36.564 83.710  1.00 34.34  ? 866  THR D CB  1 
ATOM   5981 O OG1 . THR D 1 16  ? -70.973  35.789 83.156  1.00 39.93  ? 866  THR D OG1 1 
ATOM   5982 C CG2 . THR D 1 16  ? -72.832  37.191 82.592  1.00 37.51  ? 866  THR D CG2 1 
ATOM   5983 N N   . SER D 1 17  ? -69.705  37.484 86.395  1.00 33.68  ? 867  SER D N   1 
ATOM   5984 C CA  . SER D 1 17  ? -69.101  37.051 87.677  1.00 37.80  ? 867  SER D CA  1 
ATOM   5985 C C   . SER D 1 17  ? -69.946  37.489 88.876  1.00 42.99  ? 867  SER D C   1 
ATOM   5986 O O   . SER D 1 17  ? -70.635  38.490 88.762  1.00 36.71  ? 867  SER D O   1 
ATOM   5987 C CB  . SER D 1 17  ? -67.681  37.541 87.799  1.00 37.47  ? 867  SER D CB  1 
ATOM   5988 O OG  . SER D 1 17  ? -67.644  38.893 88.201  1.00 48.21  ? 867  SER D OG  1 
ATOM   5989 N N   . SER D 1 18  ? -69.839  36.780 89.993  1.00 38.66  ? 868  SER D N   1 
ATOM   5990 C CA  . SER D 1 18  ? -70.643  37.044 91.209  1.00 38.48  ? 868  SER D CA  1 
ATOM   5991 C C   . SER D 1 18  ? -70.373  38.441 91.766  1.00 42.18  ? 868  SER D C   1 
ATOM   5992 O O   . SER D 1 18  ? -71.237  38.963 92.458  1.00 45.85  ? 868  SER D O   1 
ATOM   5993 C CB  . SER D 1 18  ? -70.377  35.987 92.253  1.00 42.47  ? 868  SER D CB  1 
ATOM   5994 O OG  . SER D 1 18  ? -69.042  36.052 92.710  1.00 49.93  ? 868  SER D OG  1 
ATOM   5995 N N   . GLU D 1 19  ? -69.214  39.001 91.477  1.00 42.08  ? 869  GLU D N   1 
ATOM   5996 C CA  . GLU D 1 19  ? -68.881  40.369 91.934  1.00 48.23  ? 869  GLU D CA  1 
ATOM   5997 C C   . GLU D 1 19  ? -69.521  41.403 91.005  1.00 49.99  ? 869  GLU D C   1 
ATOM   5998 O O   . GLU D 1 19  ? -69.620  42.554 91.406  1.00 50.57  ? 869  GLU D O   1 
ATOM   5999 C CB  . GLU D 1 19  ? -67.370  40.587 91.950  1.00 52.34  ? 869  GLU D CB  1 
ATOM   6000 C CG  . GLU D 1 19  ? -66.944  42.020 92.236  1.00 72.44  ? 869  GLU D CG  1 
ATOM   6001 C CD  . GLU D 1 19  ? -67.220  42.598 93.619  1.00 82.84  ? 869  GLU D CD  1 
ATOM   6002 O OE1 . GLU D 1 19  ? -66.664  42.075 94.607  1.00 87.88  ? 869  GLU D OE1 1 
ATOM   6003 O OE2 . GLU D 1 19  ? -67.975  43.588 93.705  1.00 78.12  ? 869  GLU D OE2 1 
ATOM   6004 N N   . SER D 1 20  ? -69.942  40.997 89.816  1.00 43.69  ? 870  SER D N   1 
ATOM   6005 C CA  . SER D 1 20  ? -70.480  41.988 88.854  1.00 43.10  ? 870  SER D CA  1 
ATOM   6006 C C   . SER D 1 20  ? -71.950  42.317 89.116  1.00 40.72  ? 870  SER D C   1 
ATOM   6007 O O   . SER D 1 20  ? -72.703  41.440 89.509  1.00 39.58  ? 870  SER D O   1 
ATOM   6008 C CB  . SER D 1 20  ? -70.302  41.555 87.426  1.00 42.24  ? 870  SER D CB  1 
ATOM   6009 O OG  . SER D 1 20  ? -70.946  42.442 86.532  1.00 39.92  ? 870  SER D OG  1 
ATOM   6010 N N   . PRO D 1 21  ? -72.351  43.583 88.896  1.00 39.71  ? 871  PRO D N   1 
ATOM   6011 C CA  . PRO D 1 21  ? -73.753  43.966 88.995  1.00 40.33  ? 871  PRO D CA  1 
ATOM   6012 C C   . PRO D 1 21  ? -74.567  43.246 87.918  1.00 39.46  ? 871  PRO D C   1 
ATOM   6013 O O   . PRO D 1 21  ? -75.746  43.273 87.981  1.00 43.60  ? 871  PRO D O   1 
ATOM   6014 C CB  . PRO D 1 21  ? -73.683  45.468 88.709  1.00 41.98  ? 871  PRO D CB  1 
ATOM   6015 C CG  . PRO D 1 21  ? -72.421  45.661 87.930  1.00 44.65  ? 871  PRO D CG  1 
ATOM   6016 C CD  . PRO D 1 21  ? -71.463  44.694 88.577  1.00 40.28  ? 871  PRO D CD  1 
ATOM   6017 N N   . ASP D 1 22  ? -73.886  42.620 86.975  1.00 33.05  ? 872  ASP D N   1 
ATOM   6018 C CA  . ASP D 1 22  ? -74.563  41.911 85.864  1.00 34.46  ? 872  ASP D CA  1 
ATOM   6019 C C   . ASP D 1 22  ? -74.559  40.394 86.091  1.00 33.23  ? 872  ASP D C   1 
ATOM   6020 O O   . ASP D 1 22  ? -74.880  39.666 85.164  1.00 33.25  ? 872  ASP D O   1 
ATOM   6021 C CB  . ASP D 1 22  ? -73.947  42.313 84.534  1.00 38.41  ? 872  ASP D CB  1 
ATOM   6022 C CG  . ASP D 1 22  ? -74.053  43.807 84.298  1.00 43.62  ? 872  ASP D CG  1 
ATOM   6023 O OD1 . ASP D 1 22  ? -75.169  44.334 84.411  1.00 42.03  ? 872  ASP D OD1 1 
ATOM   6024 O OD2 . ASP D 1 22  ? -73.024  44.419 84.013  1.00 45.87  ? 872  ASP D OD2 1 
ATOM   6025 N N   . HIS D 1 23  ? -74.264  39.968 87.313  1.00 34.91  ? 873  HIS D N   1 
ATOM   6026 C CA  . HIS D 1 23  ? -74.321  38.540 87.605  1.00 37.35  ? 873  HIS D CA  1 
ATOM   6027 C C   . HIS D 1 23  ? -75.716  37.961 87.390  1.00 33.21  ? 873  HIS D C   1 
ATOM   6028 O O   . HIS D 1 23  ? -75.845  36.798 86.988  1.00 33.27  ? 873  HIS D O   1 
ATOM   6029 C CB  . HIS D 1 23  ? -73.853  38.268 89.033  1.00 37.13  ? 873  HIS D CB  1 
ATOM   6030 C CG  . HIS D 1 23  ? -74.020  36.842 89.443  1.00 32.27  ? 873  HIS D CG  1 
ATOM   6031 N ND1 . HIS D 1 23  ? -73.336  35.813 88.833  1.00 39.02  ? 873  HIS D ND1 1 
ATOM   6032 C CD2 . HIS D 1 23  ? -74.805  36.267 90.385  1.00 41.87  ? 873  HIS D CD2 1 
ATOM   6033 C CE1 . HIS D 1 23  ? -73.688  34.665 89.385  1.00 39.37  ? 873  HIS D CE1 1 
ATOM   6034 N NE2 . HIS D 1 23  ? -74.577  34.913 90.330  1.00 40.58  ? 873  HIS D NE2 1 
ATOM   6035 N N   . TYR D 1 24  ? -76.768  38.753 87.638  1.00 34.55  ? 874  TYR D N   1 
ATOM   6036 C CA  . TYR D 1 24  ? -78.140  38.257 87.521  1.00 35.55  ? 874  TYR D CA  1 
ATOM   6037 C C   . TYR D 1 24  ? -78.404  37.597 86.170  1.00 34.07  ? 874  TYR D C   1 
ATOM   6038 O O   . TYR D 1 24  ? -79.257  36.701 86.060  1.00 35.43  ? 874  TYR D O   1 
ATOM   6039 C CB  . TYR D 1 24  ? -79.124  39.411 87.746  1.00 36.93  ? 874  TYR D CB  1 
ATOM   6040 C CG  . TYR D 1 24  ? -79.209  40.378 86.580  1.00 32.60  ? 874  TYR D CG  1 
ATOM   6041 C CD1 . TYR D 1 24  ? -78.289  41.412 86.435  1.00 35.55  ? 874  TYR D CD1 1 
ATOM   6042 C CD2 . TYR D 1 24  ? -80.208  40.255 85.622  1.00 34.81  ? 874  TYR D CD2 1 
ATOM   6043 C CE1 . TYR D 1 24  ? -78.363  42.293 85.367  1.00 33.70  ? 874  TYR D CE1 1 
ATOM   6044 C CE2 . TYR D 1 24  ? -80.289  41.129 84.554  1.00 33.21  ? 874  TYR D CE2 1 
ATOM   6045 C CZ  . TYR D 1 24  ? -79.366  42.145 84.430  1.00 34.41  ? 874  TYR D CZ  1 
ATOM   6046 O OH  . TYR D 1 24  ? -79.451  43.013 83.365  1.00 32.77  ? 874  TYR D OH  1 
ATOM   6047 N N   . LEU D 1 25  ? -77.650  37.992 85.142  1.00 32.00  ? 875  LEU D N   1 
ATOM   6048 C CA  . LEU D 1 25  ? -77.865  37.465 83.802  1.00 29.42  ? 875  LEU D CA  1 
ATOM   6049 C C   . LEU D 1 25  ? -77.639  35.963 83.710  1.00 36.80  ? 875  LEU D C   1 
ATOM   6050 O O   . LEU D 1 25  ? -78.121  35.342 82.757  1.00 34.25  ? 875  LEU D O   1 
ATOM   6051 C CB  . LEU D 1 25  ? -76.964  38.182 82.800  1.00 31.57  ? 875  LEU D CB  1 
ATOM   6052 C CG  . LEU D 1 25  ? -77.248  39.667 82.577  1.00 33.52  ? 875  LEU D CG  1 
ATOM   6053 C CD1 . LEU D 1 25  ? -76.097  40.298 81.817  1.00 35.38  ? 875  LEU D CD1 1 
ATOM   6054 C CD2 . LEU D 1 25  ? -78.559  39.865 81.831  1.00 30.73  ? 875  LEU D CD2 1 
ATOM   6055 N N   . VAL D 1 26  ? -76.919  35.356 84.659  1.00 35.80  ? 876  VAL D N   1 
ATOM   6056 C CA  . VAL D 1 26  ? -76.713  33.918 84.578  1.00 37.68  ? 876  VAL D CA  1 
ATOM   6057 C C   . VAL D 1 26  ? -78.016  33.151 84.713  1.00 37.04  ? 876  VAL D C   1 
ATOM   6058 O O   . VAL D 1 26  ? -78.058  31.959 84.396  1.00 39.73  ? 876  VAL D O   1 
ATOM   6059 C CB  . VAL D 1 26  ? -75.713  33.414 85.645  1.00 40.03  ? 876  VAL D CB  1 
ATOM   6060 C CG1 . VAL D 1 26  ? -74.380  34.137 85.528  1.00 37.50  ? 876  VAL D CG1 1 
ATOM   6061 C CG2 . VAL D 1 26  ? -76.302  33.527 87.048  1.00 37.21  ? 876  VAL D CG2 1 
ATOM   6062 N N   . ASP D 1 27  ? -79.087  33.803 85.170  1.00 36.70  ? 877  ASP D N   1 
ATOM   6063 C CA  . ASP D 1 27  ? -80.358  33.113 85.342  1.00 37.23  ? 877  ASP D CA  1 
ATOM   6064 C C   . ASP D 1 27  ? -81.283  33.221 84.128  1.00 41.14  ? 877  ASP D C   1 
ATOM   6065 O O   . ASP D 1 27  ? -82.467  32.889 84.239  1.00 37.65  ? 877  ASP D O   1 
ATOM   6066 C CB  . ASP D 1 27  ? -81.050  33.621 86.606  1.00 38.98  ? 877  ASP D CB  1 
ATOM   6067 C CG  . ASP D 1 27  ? -80.429  33.049 87.870  1.00 41.36  ? 877  ASP D CG  1 
ATOM   6068 O OD1 . ASP D 1 27  ? -79.669  32.062 87.764  1.00 45.05  ? 877  ASP D OD1 1 
ATOM   6069 O OD2 . ASP D 1 27  ? -80.692  33.586 88.965  1.00 37.65  ? 877  ASP D OD2 1 
ATOM   6070 N N   . HIS D 1 28  ? -80.753  33.709 83.001  1.00 37.56  ? 878  HIS D N   1 
ATOM   6071 C CA  . HIS D 1 28  ? -81.509  33.760 81.718  1.00 38.77  ? 878  HIS D CA  1 
ATOM   6072 C C   . HIS D 1 28  ? -80.727  32.893 80.743  1.00 43.54  ? 878  HIS D C   1 
ATOM   6073 O O   . HIS D 1 28  ? -79.913  33.423 80.002  1.00 41.72  ? 878  HIS D O   1 
ATOM   6074 C CB  . HIS D 1 28  ? -81.738  35.188 81.230  1.00 36.14  ? 878  HIS D CB  1 
ATOM   6075 C CG  . HIS D 1 28  ? -82.549  35.286 79.983  1.00 41.40  ? 878  HIS D CG  1 
ATOM   6076 N ND1 . HIS D 1 28  ? -83.864  35.693 79.985  1.00 42.89  ? 878  HIS D ND1 1 
ATOM   6077 C CD2 . HIS D 1 28  ? -82.256  35.006 78.714  1.00 36.06  ? 878  HIS D CD2 1 
ATOM   6078 C CE1 . HIS D 1 28  ? -84.328  35.671 78.749  1.00 34.49  ? 878  HIS D CE1 1 
ATOM   6079 N NE2 . HIS D 1 28  ? -83.365  35.265 77.963  1.00 43.14  ? 878  HIS D NE2 1 
ATOM   6080 N N   . THR D 1 29  ? -81.006  31.599 80.740  1.00 47.61  ? 879  THR D N   1 
ATOM   6081 C CA  . THR D 1 29  ? -80.196  30.654 79.988  1.00 45.99  ? 879  THR D CA  1 
ATOM   6082 C C   . THR D 1 29  ? -80.959  29.961 78.866  1.00 47.31  ? 879  THR D C   1 
ATOM   6083 O O   . THR D 1 29  ? -82.190  29.986 78.802  1.00 51.69  ? 879  THR D O   1 
ATOM   6084 C CB  . THR D 1 29  ? -79.617  29.569 80.902  1.00 53.43  ? 879  THR D CB  1 
ATOM   6085 O OG1 . THR D 1 29  ? -80.686  28.860 81.534  1.00 50.85  ? 879  THR D OG1 1 
ATOM   6086 C CG2 . THR D 1 29  ? -78.728  30.188 81.955  1.00 47.17  ? 879  THR D CG2 1 
ATOM   6087 N N   . LEU D 1 30  ? -80.181  29.401 77.936  1.00 47.13  ? 880  LEU D N   1 
ATOM   6088 C CA  . LEU D 1 30  ? -80.685  28.570 76.843  1.00 53.32  ? 880  LEU D CA  1 
ATOM   6089 C C   . LEU D 1 30  ? -79.765  27.364 76.677  1.00 58.60  ? 880  LEU D C   1 
ATOM   6090 O O   . LEU D 1 30  ? -78.586  27.542 76.353  1.00 55.51  ? 880  LEU D O   1 
ATOM   6091 C CB  . LEU D 1 30  ? -80.782  29.356 75.538  1.00 50.76  ? 880  LEU D CB  1 
ATOM   6092 C CG  . LEU D 1 30  ? -81.248  28.568 74.312  1.00 60.91  ? 880  LEU D CG  1 
ATOM   6093 C CD1 . LEU D 1 30  ? -82.613  27.933 74.554  1.00 57.22  ? 880  LEU D CD1 1 
ATOM   6094 C CD2 . LEU D 1 30  ? -81.276  29.468 73.089  1.00 51.96  ? 880  LEU D CD2 1 
ATOM   6095 N N   . ASP D 1 31  ? -80.281  26.153 76.939  1.00 59.55  ? 881  ASP D N   1 
ATOM   6096 C CA  . ASP D 1 31  ? -79.504  24.908 76.810  1.00 57.48  ? 881  ASP D CA  1 
ATOM   6097 C C   . ASP D 1 31  ? -78.224  25.026 77.597  1.00 56.86  ? 881  ASP D C   1 
ATOM   6098 O O   . ASP D 1 31  ? -77.133  24.629 77.174  1.00 63.47  ? 881  ASP D O   1 
ATOM   6099 C CB  . ASP D 1 31  ? -79.229  24.572 75.357  1.00 61.84  ? 881  ASP D CB  1 
ATOM   6100 C CG  . ASP D 1 31  ? -80.486  24.254 74.620  1.00 68.35  ? 881  ASP D CG  1 
ATOM   6101 O OD1 . ASP D 1 31  ? -81.372  23.619 75.232  1.00 72.85  ? 881  ASP D OD1 1 
ATOM   6102 O OD2 . ASP D 1 31  ? -80.602  24.642 73.444  1.00 68.03  ? 881  ASP D OD2 1 
ATOM   6103 N N   . GLY D 1 32  ? -78.388  25.568 78.776  1.00 55.15  ? 882  GLY D N   1 
ATOM   6104 C CA  . GLY D 1 32  ? -77.277  25.835 79.614  1.00 57.87  ? 882  GLY D CA  1 
ATOM   6105 C C   . GLY D 1 32  ? -76.416  26.977 79.183  1.00 62.89  ? 882  GLY D C   1 
ATOM   6106 O O   . GLY D 1 32  ? -75.443  27.284 79.865  1.00 62.51  ? 882  GLY D O   1 
ATOM   6107 N N   . ARG D 1 33  ? -76.732  27.730 78.168  1.00 60.84  ? 883  ARG D N   1 
ATOM   6108 C CA  . ARG D 1 33  ? -75.794  28.865 77.985  1.00 58.26  ? 883  ARG D CA  1 
ATOM   6109 C C   . ARG D 1 33  ? -76.504  30.167 78.358  1.00 51.28  ? 883  ARG D C   1 
ATOM   6110 O O   . ARG D 1 33  ? -77.718  30.198 78.295  1.00 47.94  ? 883  ARG D O   1 
ATOM   6111 C CB  . ARG D 1 33  ? -75.158  28.847 76.599  1.00 56.96  ? 883  ARG D CB  1 
ATOM   6112 C CG  . ARG D 1 33  ? -74.605  27.497 76.175  1.00 62.79  ? 883  ARG D CG  1 
ATOM   6113 C CD  . ARG D 1 33  ? -73.650  26.978 77.226  1.00 70.99  ? 883  ARG D CD  1 
ATOM   6114 N NE  . ARG D 1 33  ? -72.653  27.964 77.609  1.00 69.38  ? 883  ARG D NE  1 
ATOM   6115 C CZ  . ARG D 1 33  ? -71.720  28.445 76.801  1.00 71.33  ? 883  ARG D CZ  1 
ATOM   6116 N NH1 . ARG D 1 33  ? -71.623  28.008 75.558  1.00 71.77  ? 883  ARG D NH1 1 
ATOM   6117 N NH2 . ARG D 1 33  ? -70.874  29.352 77.247  1.00 68.92  ? 883  ARG D NH2 1 
ATOM   6118 N N   . VAL D 1 34  ? -75.745  31.170 78.782  1.00 45.60  ? 884  VAL D N   1 
ATOM   6119 C CA  . VAL D 1 34  ? -76.327  32.482 79.041  1.00 44.07  ? 884  VAL D CA  1 
ATOM   6120 C C   . VAL D 1 34  ? -76.807  33.078 77.730  1.00 43.47  ? 884  VAL D C   1 
ATOM   6121 O O   . VAL D 1 34  ? -76.028  33.266 76.789  1.00 42.79  ? 884  VAL D O   1 
ATOM   6122 C CB  . VAL D 1 34  ? -75.361  33.447 79.750  1.00 43.31  ? 884  VAL D CB  1 
ATOM   6123 C CG1 . VAL D 1 34  ? -76.116  34.736 80.091  1.00 40.92  ? 884  VAL D CG1 1 
ATOM   6124 C CG2 . VAL D 1 34  ? -74.820  32.854 81.026  1.00 48.67  ? 884  VAL D CG2 1 
ATOM   6125 N N   . LEU D 1 35  ? -78.109  33.305 77.646  1.00 41.15  ? 885  LEU D N   1 
ATOM   6126 C CA  . LEU D 1 35  ? -78.704  33.971 76.504  1.00 38.23  ? 885  LEU D CA  1 
ATOM   6127 C C   . LEU D 1 35  ? -78.918  35.414 76.937  1.00 35.68  ? 885  LEU D C   1 
ATOM   6128 O O   . LEU D 1 35  ? -79.699  35.679 77.859  1.00 36.63  ? 885  LEU D O   1 
ATOM   6129 C CB  . LEU D 1 35  ? -80.023  33.307 76.107  1.00 40.20  ? 885  LEU D CB  1 
ATOM   6130 C CG  . LEU D 1 35  ? -80.933  34.086 75.154  1.00 41.56  ? 885  LEU D CG  1 
ATOM   6131 C CD1 . LEU D 1 35  ? -80.373  34.073 73.751  1.00 41.00  ? 885  LEU D CD1 1 
ATOM   6132 C CD2 . LEU D 1 35  ? -82.343  33.512 75.159  1.00 47.39  ? 885  LEU D CD2 1 
ATOM   6133 N N   . PHE D 1 36  ? -78.246  36.345 76.265  1.00 37.16  ? 886  PHE D N   1 
ATOM   6134 C CA  . PHE D 1 36  ? -78.448  37.748 76.589  1.00 35.29  ? 886  PHE D CA  1 
ATOM   6135 C C   . PHE D 1 36  ? -79.890  38.128 76.276  1.00 33.60  ? 886  PHE D C   1 
ATOM   6136 O O   . PHE D 1 36  ? -80.359  37.890 75.155  1.00 36.52  ? 886  PHE D O   1 
ATOM   6137 C CB  . PHE D 1 36  ? -77.485  38.664 75.835  1.00 34.64  ? 886  PHE D CB  1 
ATOM   6138 C CG  . PHE D 1 36  ? -77.391  40.044 76.432  1.00 30.92  ? 886  PHE D CG  1 
ATOM   6139 C CD1 . PHE D 1 36  ? -76.624  40.272 77.565  1.00 33.14  ? 886  PHE D CD1 1 
ATOM   6140 C CD2 . PHE D 1 36  ? -78.119  41.095 75.903  1.00 31.18  ? 886  PHE D CD2 1 
ATOM   6141 C CE1 . PHE D 1 36  ? -76.553  41.534 78.131  1.00 30.62  ? 886  PHE D CE1 1 
ATOM   6142 C CE2 . PHE D 1 36  ? -78.054  42.358 76.467  1.00 27.87  ? 886  PHE D CE2 1 
ATOM   6143 C CZ  . PHE D 1 36  ? -77.271  42.577 77.582  1.00 31.92  ? 886  PHE D CZ  1 
ATOM   6144 N N   . PRO D 1 37  ? -80.625  38.695 77.229  1.00 34.13  ? 887  PRO D N   1 
ATOM   6145 C CA  . PRO D 1 37  ? -82.052  38.948 77.004  1.00 34.20  ? 887  PRO D CA  1 
ATOM   6146 C C   . PRO D 1 37  ? -82.275  40.135 76.079  1.00 33.84  ? 887  PRO D C   1 
ATOM   6147 O O   . PRO D 1 37  ? -81.545  41.128 76.125  1.00 33.27  ? 887  PRO D O   1 
ATOM   6148 C CB  . PRO D 1 37  ? -82.587  39.241 78.411  1.00 35.04  ? 887  PRO D CB  1 
ATOM   6149 C CG  . PRO D 1 37  ? -81.400  39.713 79.187  1.00 34.86  ? 887  PRO D CG  1 
ATOM   6150 C CD  . PRO D 1 37  ? -80.170  39.121 78.564  1.00 31.59  ? 887  PRO D CD  1 
ATOM   6151 N N   . ALA D 1 38  ? -83.319  40.033 75.251  1.00 34.54  ? 888  ALA D N   1 
ATOM   6152 C CA  . ALA D 1 38  ? -83.736  41.156 74.408  1.00 32.03  ? 888  ALA D CA  1 
ATOM   6153 C C   . ALA D 1 38  ? -83.924  42.441 75.225  1.00 32.19  ? 888  ALA D C   1 
ATOM   6154 O O   . ALA D 1 38  ? -83.560  43.556 74.787  1.00 33.90  ? 888  ALA D O   1 
ATOM   6155 C CB  . ALA D 1 38  ? -85.026  40.778 73.674  1.00 35.28  ? 888  ALA D CB  1 
ATOM   6156 N N   . THR D 1 39  ? -84.475  42.305 76.432  1.00 28.30  ? 889  THR D N   1 
ATOM   6157 C CA  . THR D 1 39  ? -84.685  43.481 77.263  1.00 25.18  ? 889  THR D CA  1 
ATOM   6158 C C   . THR D 1 39  ? -83.363  44.072 77.751  1.00 28.62  ? 889  THR D C   1 
ATOM   6159 O O   . THR D 1 39  ? -83.302  45.269 78.074  1.00 33.07  ? 889  THR D O   1 
ATOM   6160 C CB  . THR D 1 39  ? -85.594  43.124 78.442  1.00 30.44  ? 889  THR D CB  1 
ATOM   6161 O OG1 . THR D 1 39  ? -85.008  42.057 79.196  1.00 30.45  ? 889  THR D OG1 1 
ATOM   6162 C CG2 . THR D 1 39  ? -86.954  42.655 77.928  1.00 27.42  ? 889  THR D CG2 1 
ATOM   6163 N N   . GLY D 1 40  ? -82.288  43.280 77.747  1.00 32.06  ? 890  GLY D N   1 
ATOM   6164 C CA  . GLY D 1 40  ? -80.972  43.835 78.029  1.00 32.19  ? 890  GLY D CA  1 
ATOM   6165 C C   . GLY D 1 40  ? -80.491  44.791 76.949  1.00 30.23  ? 890  GLY D C   1 
ATOM   6166 O O   . GLY D 1 40  ? -79.839  45.806 77.243  1.00 30.14  ? 890  GLY D O   1 
ATOM   6167 N N   . TYR D 1 41  ? -80.810  44.488 75.685  1.00 29.31  ? 891  TYR D N   1 
ATOM   6168 C CA  . TYR D 1 41  ? -80.499  45.429 74.614  1.00 30.40  ? 891  TYR D CA  1 
ATOM   6169 C C   . TYR D 1 41  ? -81.253  46.728 74.814  1.00 30.88  ? 891  TYR D C   1 
ATOM   6170 O O   . TYR D 1 41  ? -80.687  47.820 74.640  1.00 30.27  ? 891  TYR D O   1 
ATOM   6171 C CB  . TYR D 1 41  ? -80.854  44.851 73.246  1.00 28.55  ? 891  TYR D CB  1 
ATOM   6172 C CG  . TYR D 1 41  ? -80.232  43.521 72.932  1.00 31.40  ? 891  TYR D CG  1 
ATOM   6173 C CD1 . TYR D 1 41  ? -78.860  43.339 73.006  1.00 32.02  ? 891  TYR D CD1 1 
ATOM   6174 C CD2 . TYR D 1 41  ? -81.018  42.452 72.528  1.00 31.00  ? 891  TYR D CD2 1 
ATOM   6175 C CE1 . TYR D 1 41  ? -78.291  42.122 72.707  1.00 31.83  ? 891  TYR D CE1 1 
ATOM   6176 C CE2 . TYR D 1 41  ? -80.460  41.235 72.228  1.00 30.52  ? 891  TYR D CE2 1 
ATOM   6177 C CZ  . TYR D 1 41  ? -79.097  41.074 72.320  1.00 33.19  ? 891  TYR D CZ  1 
ATOM   6178 O OH  . TYR D 1 41  ? -78.542  39.857 72.019  1.00 36.40  ? 891  TYR D OH  1 
ATOM   6179 N N   . LEU D 1 42  ? -82.543  46.631 75.165  1.00 31.20  ? 892  LEU D N   1 
ATOM   6180 C CA  . LEU D 1 42  ? -83.272  47.866 75.462  1.00 29.12  ? 892  LEU D CA  1 
ATOM   6181 C C   . LEU D 1 42  ? -82.571  48.678 76.544  1.00 29.85  ? 892  LEU D C   1 
ATOM   6182 O O   . LEU D 1 42  ? -82.491  49.911 76.455  1.00 29.98  ? 892  LEU D O   1 
ATOM   6183 C CB  . LEU D 1 42  ? -84.700  47.566 75.896  1.00 30.60  ? 892  LEU D CB  1 
ATOM   6184 C CG  . LEU D 1 42  ? -85.537  46.755 74.924  1.00 32.08  ? 892  LEU D CG  1 
ATOM   6185 C CD1 . LEU D 1 42  ? -86.863  46.433 75.579  1.00 35.38  ? 892  LEU D CD1 1 
ATOM   6186 C CD2 . LEU D 1 42  ? -85.729  47.530 73.629  1.00 33.39  ? 892  LEU D CD2 1 
ATOM   6187 N N   . SER D 1 43  ? -82.076  48.001 77.582  1.00 28.76  ? 893  SER D N   1 
ATOM   6188 C CA  . SER D 1 43  ? -81.422  48.709 78.680  1.00 28.44  ? 893  SER D CA  1 
ATOM   6189 C C   . SER D 1 43  ? -80.191  49.478 78.205  1.00 24.99  ? 893  SER D C   1 
ATOM   6190 O O   . SER D 1 43  ? -80.016  50.659 78.538  1.00 25.16  ? 893  SER D O   1 
ATOM   6191 C CB  . SER D 1 43  ? -81.042  47.722 79.781  1.00 31.09  ? 893  SER D CB  1 
ATOM   6192 O OG  . SER D 1 43  ? -80.373  48.380 80.841  1.00 29.58  ? 893  SER D OG  1 
ATOM   6193 N N   . ILE D 1 44  ? -79.311  48.820 77.445  1.00 28.10  ? 894  ILE D N   1 
ATOM   6194 C CA  . ILE D 1 44  ? -78.069  49.505 77.070  1.00 25.99  ? 894  ILE D CA  1 
ATOM   6195 C C   . ILE D 1 44  ? -78.329  50.607 76.036  1.00 27.86  ? 894  ILE D C   1 
ATOM   6196 O O   . ILE D 1 44  ? -77.653  51.650 76.047  1.00 27.51  ? 894  ILE D O   1 
ATOM   6197 C CB  . ILE D 1 44  ? -76.999  48.491 76.613  1.00 27.81  ? 894  ILE D CB  1 
ATOM   6198 C CG1 . ILE D 1 44  ? -77.429  47.732 75.355  1.00 27.51  ? 894  ILE D CG1 1 
ATOM   6199 C CG2 . ILE D 1 44  ? -76.650  47.535 77.754  1.00 28.56  ? 894  ILE D CG2 1 
ATOM   6200 C CD1 . ILE D 1 44  ? -76.323  46.861 74.768  1.00 30.17  ? 894  ILE D CD1 1 
ATOM   6201 N N   . VAL D 1 45  ? -79.345  50.445 75.182  1.00 26.73  ? 895  VAL D N   1 
ATOM   6202 C CA  . VAL D 1 45  ? -79.714  51.533 74.274  1.00 25.41  ? 895  VAL D CA  1 
ATOM   6203 C C   . VAL D 1 45  ? -80.249  52.729 75.059  1.00 28.28  ? 895  VAL D C   1 
ATOM   6204 O O   . VAL D 1 45  ? -79.893  53.887 74.794  1.00 26.50  ? 895  VAL D O   1 
ATOM   6205 C CB  . VAL D 1 45  ? -80.742  51.045 73.238  1.00 27.85  ? 895  VAL D CB  1 
ATOM   6206 C CG1 . VAL D 1 45  ? -81.232  52.208 72.395  1.00 27.12  ? 895  VAL D CG1 1 
ATOM   6207 C CG2 . VAL D 1 45  ? -80.141  49.973 72.355  1.00 27.11  ? 895  VAL D CG2 1 
ATOM   6208 N N   . TRP D 1 46  ? -81.135  52.460 76.021  1.00 26.51  ? 896  TRP D N   1 
ATOM   6209 C CA  . TRP D 1 46  ? -81.666  53.501 76.895  1.00 25.70  ? 896  TRP D CA  1 
ATOM   6210 C C   . TRP D 1 46  ? -80.547  54.253 77.604  1.00 28.36  ? 896  TRP D C   1 
ATOM   6211 O O   . TRP D 1 46  ? -80.562  55.489 77.678  1.00 27.09  ? 896  TRP D O   1 
ATOM   6212 C CB  . TRP D 1 46  ? -82.611  52.836 77.894  1.00 26.58  ? 896  TRP D CB  1 
ATOM   6213 C CG  . TRP D 1 46  ? -83.476  53.709 78.735  1.00 27.03  ? 896  TRP D CG  1 
ATOM   6214 C CD1 . TRP D 1 46  ? -83.694  55.050 78.609  1.00 31.06  ? 896  TRP D CD1 1 
ATOM   6215 C CD2 . TRP D 1 46  ? -84.262  53.274 79.845  1.00 27.60  ? 896  TRP D CD2 1 
ATOM   6216 N NE1 . TRP D 1 46  ? -84.568  55.476 79.586  1.00 32.01  ? 896  TRP D NE1 1 
ATOM   6217 C CE2 . TRP D 1 46  ? -84.930  54.401 80.356  1.00 31.34  ? 896  TRP D CE2 1 
ATOM   6218 C CE3 . TRP D 1 46  ? -84.462  52.033 80.459  1.00 32.52  ? 896  TRP D CE3 1 
ATOM   6219 C CZ2 . TRP D 1 46  ? -85.785  54.325 81.455  1.00 31.03  ? 896  TRP D CZ2 1 
ATOM   6220 C CZ3 . TRP D 1 46  ? -85.308  51.959 81.546  1.00 30.69  ? 896  TRP D CZ3 1 
ATOM   6221 C CH2 . TRP D 1 46  ? -85.960  53.097 82.033  1.00 28.47  ? 896  TRP D CH2 1 
ATOM   6222 N N   . LYS D 1 47  ? -79.560  53.517 78.123  1.00 25.89  ? 897  LYS D N   1 
ATOM   6223 C CA  . LYS D 1 47  ? -78.431  54.138 78.809  1.00 27.13  ? 897  LYS D CA  1 
ATOM   6224 C C   . LYS D 1 47  ? -77.611  55.003 77.862  1.00 28.92  ? 897  LYS D C   1 
ATOM   6225 O O   . LYS D 1 47  ? -77.086  56.053 78.261  1.00 30.62  ? 897  LYS D O   1 
ATOM   6226 C CB  . LYS D 1 47  ? -77.550  53.048 79.412  1.00 27.26  ? 897  LYS D CB  1 
ATOM   6227 C CG  . LYS D 1 47  ? -78.098  52.452 80.690  1.00 29.60  ? 897  LYS D CG  1 
ATOM   6228 C CD  . LYS D 1 47  ? -77.154  51.411 81.258  1.00 34.04  ? 897  LYS D CD  1 
ATOM   6229 C CE  . LYS D 1 47  ? -77.786  50.693 82.438  1.00 35.91  ? 897  LYS D CE  1 
ATOM   6230 N NZ  . LYS D 1 47  ? -76.923  49.594 82.949  1.00 30.27  ? 897  LYS D NZ  1 
ATOM   6231 N N   . THR D 1 48  ? -77.515  54.589 76.598  1.00 26.44  ? 898  THR D N   1 
ATOM   6232 C CA  . THR D 1 48  ? -76.740  55.349 75.624  1.00 27.38  ? 898  THR D CA  1 
ATOM   6233 C C   . THR D 1 48  ? -77.434  56.665 75.271  1.00 28.27  ? 898  THR D C   1 
ATOM   6234 O O   . THR D 1 48  ? -76.793  57.730 75.204  1.00 28.01  ? 898  THR D O   1 
ATOM   6235 C CB  . THR D 1 48  ? -76.529  54.470 74.392  1.00 26.63  ? 898  THR D CB  1 
ATOM   6236 O OG1 . THR D 1 48  ? -75.840  53.276 74.787  1.00 27.01  ? 898  THR D OG1 1 
ATOM   6237 C CG2 . THR D 1 48  ? -75.700  55.188 73.347  1.00 26.89  ? 898  THR D CG2 1 
ATOM   6238 N N   . LEU D 1 49  ? -78.754  56.617 75.078  1.00 26.72  ? 899  LEU D N   1 
ATOM   6239 C CA  . LEU D 1 49  ? -79.505  57.855 74.876  1.00 27.64  ? 899  LEU D CA  1 
ATOM   6240 C C   . LEU D 1 49  ? -79.398  58.768 76.094  1.00 29.42  ? 899  LEU D C   1 
ATOM   6241 O O   . LEU D 1 49  ? -79.204  59.985 75.956  1.00 28.31  ? 899  LEU D O   1 
ATOM   6242 C CB  . LEU D 1 49  ? -80.969  57.548 74.557  1.00 24.69  ? 899  LEU D CB  1 
ATOM   6243 C CG  . LEU D 1 49  ? -81.843  58.788 74.347  1.00 30.60  ? 899  LEU D CG  1 
ATOM   6244 C CD1 . LEU D 1 49  ? -81.351  59.608 73.160  1.00 31.47  ? 899  LEU D CD1 1 
ATOM   6245 C CD2 . LEU D 1 49  ? -83.305  58.405 74.169  1.00 34.10  ? 899  LEU D CD2 1 
ATOM   6246 N N   . ALA D 1 50  ? -79.511  58.195 77.298  1.00 29.38  ? 900  ALA D N   1 
ATOM   6247 C CA  . ALA D 1 50  ? -79.381  58.994 78.514  1.00 28.86  ? 900  ALA D CA  1 
ATOM   6248 C C   . ALA D 1 50  ? -78.037  59.705 78.565  1.00 30.05  ? 900  ALA D C   1 
ATOM   6249 O O   . ALA D 1 50  ? -77.961  60.876 78.955  1.00 33.73  ? 900  ALA D O   1 
ATOM   6250 C CB  . ALA D 1 50  ? -79.574  58.113 79.748  1.00 30.72  ? 900  ALA D CB  1 
ATOM   6251 N N   . ARG D 1 51  ? -76.962  59.007 78.185  1.00 29.53  ? 901  ARG D N   1 
ATOM   6252 C CA  . ARG D 1 51  ? -75.649  59.645 78.143  1.00 33.16  ? 901  ARG D CA  1 
ATOM   6253 C C   . ARG D 1 51  ? -75.650  60.824 77.177  1.00 34.03  ? 901  ARG D C   1 
ATOM   6254 O O   . ARG D 1 51  ? -75.113  61.895 77.490  1.00 31.87  ? 901  ARG D O   1 
ATOM   6255 C CB  . ARG D 1 51  ? -74.586  58.626 77.738  1.00 31.64  ? 901  ARG D CB  1 
ATOM   6256 C CG  . ARG D 1 51  ? -73.150  59.067 77.983  1.00 33.98  ? 901  ARG D CG  1 
ATOM   6257 C CD  . ARG D 1 51  ? -72.857  59.070 79.477  1.00 29.08  ? 901  ARG D CD  1 
ATOM   6258 N NE  . ARG D 1 51  ? -71.488  59.457 79.793  1.00 33.68  ? 901  ARG D NE  1 
ATOM   6259 C CZ  . ARG D 1 51  ? -70.929  59.298 80.986  1.00 39.66  ? 901  ARG D CZ  1 
ATOM   6260 N NH1 . ARG D 1 51  ? -71.604  58.786 82.002  1.00 34.70  ? 901  ARG D NH1 1 
ATOM   6261 N NH2 . ARG D 1 51  ? -69.660  59.656 81.161  1.00 32.20  ? 901  ARG D NH2 1 
ATOM   6262 N N   . ALA D 1 52  ? -76.256  60.644 75.998  1.00 31.53  ? 902  ALA D N   1 
ATOM   6263 C CA  . ALA D 1 52  ? -76.295  61.734 75.022  1.00 31.45  ? 902  ALA D CA  1 
ATOM   6264 C C   . ALA D 1 52  ? -77.085  62.931 75.535  1.00 37.01  ? 902  ALA D C   1 
ATOM   6265 O O   . ALA D 1 52  ? -76.804  64.074 75.152  1.00 35.94  ? 902  ALA D O   1 
ATOM   6266 C CB  . ALA D 1 52  ? -76.894  61.244 73.706  1.00 30.06  ? 902  ALA D CB  1 
ATOM   6267 N N   . LEU D 1 53  ? -78.069  62.693 76.397  1.00 35.47  ? 903  LEU D N   1 
ATOM   6268 C CA  . LEU D 1 53  ? -78.922  63.754 76.916  1.00 35.30  ? 903  LEU D CA  1 
ATOM   6269 C C   . LEU D 1 53  ? -78.441  64.310 78.250  1.00 41.00  ? 903  LEU D C   1 
ATOM   6270 O O   . LEU D 1 53  ? -79.063  65.238 78.779  1.00 38.86  ? 903  LEU D O   1 
ATOM   6271 C CB  . LEU D 1 53  ? -80.354  63.237 77.060  1.00 33.65  ? 903  LEU D CB  1 
ATOM   6272 C CG  . LEU D 1 53  ? -81.010  62.875 75.728  1.00 31.98  ? 903  LEU D CG  1 
ATOM   6273 C CD1 . LEU D 1 53  ? -82.362  62.222 75.954  1.00 34.11  ? 903  LEU D CD1 1 
ATOM   6274 C CD2 . LEU D 1 53  ? -81.140  64.103 74.838  1.00 36.39  ? 903  LEU D CD2 1 
ATOM   6275 N N   . GLY D 1 54  ? -77.365  63.762 78.809  1.00 37.40  ? 904  GLY D N   1 
ATOM   6276 C CA  . GLY D 1 54  ? -76.892  64.190 80.111  1.00 39.19  ? 904  GLY D CA  1 
ATOM   6277 C C   . GLY D 1 54  ? -77.814  63.825 81.252  1.00 42.10  ? 904  GLY D C   1 
ATOM   6278 O O   . GLY D 1 54  ? -77.851  64.537 82.262  1.00 40.03  ? 904  GLY D O   1 
ATOM   6279 N N   . LEU D 1 55  ? -78.552  62.724 81.124  1.00 36.59  ? 905  LEU D N   1 
ATOM   6280 C CA  . LEU D 1 55  ? -79.546  62.304 82.099  1.00 36.91  ? 905  LEU D CA  1 
ATOM   6281 C C   . LEU D 1 55  ? -79.235  60.910 82.629  1.00 40.26  ? 905  LEU D C   1 
ATOM   6282 O O   . LEU D 1 55  ? -78.471  60.148 82.031  1.00 38.56  ? 905  LEU D O   1 
ATOM   6283 C CB  . LEU D 1 55  ? -80.951  62.291 81.487  1.00 37.34  ? 905  LEU D CB  1 
ATOM   6284 C CG  . LEU D 1 55  ? -81.482  63.614 80.945  1.00 38.81  ? 905  LEU D CG  1 
ATOM   6285 C CD1 . LEU D 1 55  ? -82.759  63.380 80.150  1.00 44.01  ? 905  LEU D CD1 1 
ATOM   6286 C CD2 . LEU D 1 55  ? -81.700  64.611 82.072  1.00 43.23  ? 905  LEU D CD2 1 
ATOM   6287 N N   . GLY D 1 56  ? -79.832  60.596 83.776  1.00 36.98  ? 906  GLY D N   1 
ATOM   6288 C CA  . GLY D 1 56  ? -79.961  59.221 84.218  1.00 35.28  ? 906  GLY D CA  1 
ATOM   6289 C C   . GLY D 1 56  ? -81.218  58.597 83.633  1.00 35.80  ? 906  GLY D C   1 
ATOM   6290 O O   . GLY D 1 56  ? -82.170  59.295 83.297  1.00 36.43  ? 906  GLY D O   1 
ATOM   6291 N N   . VAL D 1 57  ? -81.208  57.269 83.483  1.00 36.62  ? 907  VAL D N   1 
ATOM   6292 C CA  . VAL D 1 57  ? -82.361  56.603 82.875  1.00 35.58  ? 907  VAL D CA  1 
ATOM   6293 C C   . VAL D 1 57  ? -83.638  56.866 83.668  1.00 37.87  ? 907  VAL D C   1 
ATOM   6294 O O   . VAL D 1 57  ? -84.725  56.953 83.084  1.00 34.47  ? 907  VAL D O   1 
ATOM   6295 C CB  . VAL D 1 57  ? -82.110  55.090 82.702  1.00 37.69  ? 907  VAL D CB  1 
ATOM   6296 C CG1 . VAL D 1 57  ? -81.029  54.841 81.651  1.00 37.21  ? 907  VAL D CG1 1 
ATOM   6297 C CG2 . VAL D 1 57  ? -81.767  54.431 84.030  1.00 38.58  ? 907  VAL D CG2 1 
ATOM   6298 N N   . GLU D 1 58  ? -83.545  56.986 84.996  1.00 39.74  ? 908  GLU D N   1 
ATOM   6299 C CA  . GLU D 1 58  ? -84.755  57.232 85.779  1.00 40.23  ? 908  GLU D CA  1 
ATOM   6300 C C   . GLU D 1 58  ? -85.380  58.595 85.509  1.00 40.52  ? 908  GLU D C   1 
ATOM   6301 O O   . GLU D 1 58  ? -86.530  58.814 85.907  1.00 44.14  ? 908  GLU D O   1 
ATOM   6302 C CB  . GLU D 1 58  ? -84.485  57.083 87.276  1.00 43.29  ? 908  GLU D CB  1 
ATOM   6303 C CG  . GLU D 1 58  ? -83.967  55.720 87.691  1.00 47.48  ? 908  GLU D CG  1 
ATOM   6304 C CD  . GLU D 1 58  ? -85.050  54.655 87.648  1.00 50.03  ? 908  GLU D CD  1 
ATOM   6305 O OE1 . GLU D 1 58  ? -86.196  54.952 88.046  1.00 50.93  ? 908  GLU D OE1 1 
ATOM   6306 O OE2 . GLU D 1 58  ? -84.748  53.514 87.239  1.00 46.29  ? 908  GLU D OE2 1 
ATOM   6307 N N   . GLN D 1 59  ? -84.660  59.515 84.872  1.00 36.94  ? 909  GLN D N   1 
ATOM   6308 C CA  . GLN D 1 59  ? -85.219  60.796 84.464  1.00 38.31  ? 909  GLN D CA  1 
ATOM   6309 C C   . GLN D 1 59  ? -85.471  60.841 82.966  1.00 37.88  ? 909  GLN D C   1 
ATOM   6310 O O   . GLN D 1 59  ? -85.660  61.926 82.405  1.00 36.75  ? 909  GLN D O   1 
ATOM   6311 C CB  . GLN D 1 59  ? -84.302  61.945 84.883  1.00 45.13  ? 909  GLN D CB  1 
ATOM   6312 C CG  . GLN D 1 59  ? -84.305  62.205 86.376  1.00 48.59  ? 909  GLN D CG  1 
ATOM   6313 C CD  . GLN D 1 59  ? -83.409  61.242 87.124  1.00 48.19  ? 909  GLN D CD  1 
ATOM   6314 O OE1 . GLN D 1 59  ? -83.864  60.499 87.993  1.00 57.05  ? 909  GLN D OE1 1 
ATOM   6315 N NE2 . GLN D 1 59  ? -82.126  61.246 86.786  1.00 49.35  ? 909  GLN D NE2 1 
ATOM   6316 N N   . LEU D 1 60  ? -85.452  59.685 82.302  1.00 35.94  ? 910  LEU D N   1 
ATOM   6317 C CA  . LEU D 1 60  ? -85.563  59.595 80.851  1.00 34.33  ? 910  LEU D CA  1 
ATOM   6318 C C   . LEU D 1 60  ? -86.723  58.677 80.490  1.00 30.64  ? 910  LEU D C   1 
ATOM   6319 O O   . LEU D 1 60  ? -86.518  57.491 80.189  1.00 32.07  ? 910  LEU D O   1 
ATOM   6320 C CB  . LEU D 1 60  ? -84.272  59.076 80.222  1.00 30.70  ? 910  LEU D CB  1 
ATOM   6321 C CG  . LEU D 1 60  ? -84.240  59.133 78.692  1.00 34.20  ? 910  LEU D CG  1 
ATOM   6322 C CD1 . LEU D 1 60  ? -84.789  60.456 78.177  1.00 34.04  ? 910  LEU D CD1 1 
ATOM   6323 C CD2 . LEU D 1 60  ? -82.851  58.868 78.157  1.00 29.40  ? 910  LEU D CD2 1 
ATOM   6324 N N   . PRO D 1 61  ? -87.948  59.192 80.472  1.00 32.23  ? 911  PRO D N   1 
ATOM   6325 C CA  . PRO D 1 61  ? -89.021  58.455 79.800  1.00 36.08  ? 911  PRO D CA  1 
ATOM   6326 C C   . PRO D 1 61  ? -88.653  58.308 78.332  1.00 32.20  ? 911  PRO D C   1 
ATOM   6327 O O   . PRO D 1 61  ? -88.149  59.244 77.707  1.00 33.93  ? 911  PRO D O   1 
ATOM   6328 C CB  . PRO D 1 61  ? -90.259  59.332 80.013  1.00 37.71  ? 911  PRO D CB  1 
ATOM   6329 C CG  . PRO D 1 61  ? -89.747  60.672 80.419  1.00 40.47  ? 911  PRO D CG  1 
ATOM   6330 C CD  . PRO D 1 61  ? -88.380  60.501 80.991  1.00 37.46  ? 911  PRO D CD  1 
ATOM   6331 N N   . VAL D 1 62  ? -88.883  57.114 77.788  1.00 31.50  ? 912  VAL D N   1 
ATOM   6332 C CA  . VAL D 1 62  ? -88.260  56.726 76.528  1.00 31.59  ? 912  VAL D CA  1 
ATOM   6333 C C   . VAL D 1 62  ? -89.237  55.923 75.679  1.00 32.61  ? 912  VAL D C   1 
ATOM   6334 O O   . VAL D 1 62  ? -90.088  55.190 76.196  1.00 32.17  ? 912  VAL D O   1 
ATOM   6335 C CB  . VAL D 1 62  ? -86.962  55.918 76.783  1.00 30.96  ? 912  VAL D CB  1 
ATOM   6336 C CG1 . VAL D 1 62  ? -87.274  54.618 77.515  1.00 33.32  ? 912  VAL D CG1 1 
ATOM   6337 C CG2 . VAL D 1 62  ? -86.215  55.644 75.485  1.00 29.63  ? 912  VAL D CG2 1 
ATOM   6338 N N   . VAL D 1 63  ? -89.117  56.080 74.359  1.00 30.80  ? 913  VAL D N   1 
ATOM   6339 C CA  . VAL D 1 63  ? -89.871  55.297 73.387  1.00 29.77  ? 913  VAL D CA  1 
ATOM   6340 C C   . VAL D 1 63  ? -88.895  54.561 72.476  1.00 31.23  ? 913  VAL D C   1 
ATOM   6341 O O   . VAL D 1 63  ? -87.926  55.153 71.988  1.00 30.47  ? 913  VAL D O   1 
ATOM   6342 C CB  . VAL D 1 63  ? -90.817  56.175 72.548  1.00 34.58  ? 913  VAL D CB  1 
ATOM   6343 C CG1 . VAL D 1 63  ? -91.740  55.294 71.716  1.00 30.47  ? 913  VAL D CG1 1 
ATOM   6344 C CG2 . VAL D 1 63  ? -91.611  57.121 73.435  1.00 35.45  ? 913  VAL D CG2 1 
ATOM   6345 N N   . PHE D 1 64  ? -89.147  53.271 72.268  1.00 30.33  ? 914  PHE D N   1 
ATOM   6346 C CA  . PHE D 1 64  ? -88.523  52.462 71.230  1.00 29.66  ? 914  PHE D CA  1 
ATOM   6347 C C   . PHE D 1 64  ? -89.555  52.176 70.146  1.00 37.71  ? 914  PHE D C   1 
ATOM   6348 O O   . PHE D 1 64  ? -90.709  51.872 70.456  1.00 36.76  ? 914  PHE D O   1 
ATOM   6349 C CB  . PHE D 1 64  ? -88.023  51.128 71.792  1.00 32.80  ? 914  PHE D CB  1 
ATOM   6350 C CG  . PHE D 1 64  ? -86.960  51.252 72.848  1.00 30.88  ? 914  PHE D CG  1 
ATOM   6351 C CD1 . PHE D 1 64  ? -87.301  51.517 74.165  1.00 31.65  ? 914  PHE D CD1 1 
ATOM   6352 C CD2 . PHE D 1 64  ? -85.626  51.044 72.536  1.00 35.15  ? 914  PHE D CD2 1 
ATOM   6353 C CE1 . PHE D 1 64  ? -86.330  51.609 75.145  1.00 35.74  ? 914  PHE D CE1 1 
ATOM   6354 C CE2 . PHE D 1 64  ? -84.649  51.132 73.513  1.00 33.68  ? 914  PHE D CE2 1 
ATOM   6355 C CZ  . PHE D 1 64  ? -85.002  51.415 74.818  1.00 33.50  ? 914  PHE D CZ  1 
ATOM   6356 N N   . GLU D 1 65  ? -89.146  52.250 68.880  1.00 27.67  ? 915  GLU D N   1 
ATOM   6357 C CA  . GLU D 1 65  ? -90.045  51.940 67.772  1.00 31.31  ? 915  GLU D CA  1 
ATOM   6358 C C   . GLU D 1 65  ? -89.336  51.096 66.720  1.00 37.26  ? 915  GLU D C   1 
ATOM   6359 O O   . GLU D 1 65  ? -88.133  51.248 66.485  1.00 32.07  ? 915  GLU D O   1 
ATOM   6360 C CB  . GLU D 1 65  ? -90.609  53.211 67.123  1.00 35.58  ? 915  GLU D CB  1 
ATOM   6361 C CG  . GLU D 1 65  ? -91.398  54.092 68.078  1.00 35.18  ? 915  GLU D CG  1 
ATOM   6362 C CD  . GLU D 1 65  ? -92.049  55.274 67.391  1.00 42.56  ? 915  GLU D CD  1 
ATOM   6363 O OE1 . GLU D 1 65  ? -91.630  55.616 66.265  1.00 34.99  ? 915  GLU D OE1 1 
ATOM   6364 O OE2 . GLU D 1 65  ? -92.963  55.878 67.990  1.00 36.78  ? 915  GLU D OE2 1 
ATOM   6365 N N   . ASP D 1 66  ? -90.103  50.205 66.084  1.00 31.04  ? 916  ASP D N   1 
ATOM   6366 C CA  . ASP D 1 66  ? -89.624  49.391 64.962  1.00 34.77  ? 916  ASP D CA  1 
ATOM   6367 C C   . ASP D 1 66  ? -88.342  48.644 65.318  1.00 40.48  ? 916  ASP D C   1 
ATOM   6368 O O   . ASP D 1 66  ? -87.388  48.590 64.538  1.00 33.22  ? 916  ASP D O   1 
ATOM   6369 C CB  . ASP D 1 66  ? -89.426  50.243 63.707  1.00 36.55  ? 916  ASP D CB  1 
ATOM   6370 C CG  . ASP D 1 66  ? -90.618  51.129 63.413  1.00 45.65  ? 916  ASP D CG  1 
ATOM   6371 O OD1 . ASP D 1 66  ? -91.756  50.618 63.459  1.00 39.95  ? 916  ASP D OD1 1 
ATOM   6372 O OD2 . ASP D 1 66  ? -90.419  52.332 63.143  1.00 43.28  ? 916  ASP D OD2 1 
ATOM   6373 N N   . VAL D 1 67  ? -88.324  48.060 66.514  1.00 36.08  ? 917  VAL D N   1 
ATOM   6374 C CA  . VAL D 1 67  ? -87.168  47.298 66.968  1.00 33.12  ? 917  VAL D CA  1 
ATOM   6375 C C   . VAL D 1 67  ? -87.096  45.980 66.211  1.00 37.80  ? 917  VAL D C   1 
ATOM   6376 O O   . VAL D 1 67  ? -88.098  45.268 66.072  1.00 36.73  ? 917  VAL D O   1 
ATOM   6377 C CB  . VAL D 1 67  ? -87.241  47.071 68.485  1.00 28.57  ? 917  VAL D CB  1 
ATOM   6378 C CG1 . VAL D 1 67  ? -86.072  46.220 68.956  1.00 33.30  ? 917  VAL D CG1 1 
ATOM   6379 C CG2 . VAL D 1 67  ? -87.256  48.404 69.212  1.00 27.80  ? 917  VAL D CG2 1 
ATOM   6380 N N   . VAL D 1 68  ? -85.907  45.655 65.706  1.00 29.86  ? 918  VAL D N   1 
ATOM   6381 C CA  . VAL D 1 68  ? -85.658  44.406 64.997  1.00 32.15  ? 918  VAL D CA  1 
ATOM   6382 C C   . VAL D 1 68  ? -84.466  43.717 65.643  1.00 36.72  ? 918  VAL D C   1 
ATOM   6383 O O   . VAL D 1 68  ? -83.394  44.316 65.775  1.00 33.39  ? 918  VAL D O   1 
ATOM   6384 C CB  . VAL D 1 68  ? -85.389  44.627 63.496  1.00 35.86  ? 918  VAL D CB  1 
ATOM   6385 C CG1 . VAL D 1 68  ? -85.070  43.300 62.822  1.00 33.05  ? 918  VAL D CG1 1 
ATOM   6386 C CG2 . VAL D 1 68  ? -86.581  45.289 62.826  1.00 36.66  ? 918  VAL D CG2 1 
ATOM   6387 N N   . LEU D 1 69  ? -84.656  42.466 66.051  1.00 31.06  ? 919  LEU D N   1 
ATOM   6388 C CA  . LEU D 1 69  ? -83.584  41.656 66.611  1.00 36.37  ? 919  LEU D CA  1 
ATOM   6389 C C   . LEU D 1 69  ? -83.087  40.713 65.527  1.00 42.01  ? 919  LEU D C   1 
ATOM   6390 O O   . LEU D 1 69  ? -83.834  39.851 65.052  1.00 41.68  ? 919  LEU D O   1 
ATOM   6391 C CB  . LEU D 1 69  ? -84.042  40.883 67.844  1.00 32.69  ? 919  LEU D CB  1 
ATOM   6392 C CG  . LEU D 1 69  ? -84.417  41.791 69.012  1.00 38.89  ? 919  LEU D CG  1 
ATOM   6393 C CD1 . LEU D 1 69  ? -85.923  41.975 69.085  1.00 41.37  ? 919  LEU D CD1 1 
ATOM   6394 C CD2 . LEU D 1 69  ? -83.857  41.242 70.310  1.00 40.87  ? 919  LEU D CD2 1 
ATOM   6395 N N   . HIS D 1 70  ? -81.834  40.900 65.127  1.00 36.10  ? 920  HIS D N   1 
ATOM   6396 C CA  . HIS D 1 70  ? -81.265  40.225 63.972  1.00 36.97  ? 920  HIS D CA  1 
ATOM   6397 C C   . HIS D 1 70  ? -80.622  38.894 64.313  1.00 42.31  ? 920  HIS D C   1 
ATOM   6398 O O   . HIS D 1 70  ? -80.477  38.045 63.426  1.00 41.93  ? 920  HIS D O   1 
ATOM   6399 C CB  . HIS D 1 70  ? -80.244  41.150 63.315  1.00 35.07  ? 920  HIS D CB  1 
ATOM   6400 C CG  . HIS D 1 70  ? -80.830  42.454 62.882  1.00 33.14  ? 920  HIS D CG  1 
ATOM   6401 N ND1 . HIS D 1 70  ? -81.364  42.646 61.627  1.00 37.12  ? 920  HIS D ND1 1 
ATOM   6402 C CD2 . HIS D 1 70  ? -81.026  43.613 63.555  1.00 35.00  ? 920  HIS D CD2 1 
ATOM   6403 C CE1 . HIS D 1 70  ? -81.830  43.878 61.532  1.00 38.46  ? 920  HIS D CE1 1 
ATOM   6404 N NE2 . HIS D 1 70  ? -81.640  44.485 62.690  1.00 36.00  ? 920  HIS D NE2 1 
ATOM   6405 N N   . GLN D 1 71  ? -80.218  38.702 65.564  1.00 40.37  ? 921  GLN D N   1 
ATOM   6406 C CA  . GLN D 1 71  ? -79.626  37.447 65.996  1.00 37.76  ? 921  GLN D CA  1 
ATOM   6407 C C   . GLN D 1 71  ? -79.659  37.408 67.514  1.00 38.58  ? 921  GLN D C   1 
ATOM   6408 O O   . GLN D 1 71  ? -79.801  38.439 68.176  1.00 41.40  ? 921  GLN D O   1 
ATOM   6409 C CB  . GLN D 1 71  ? -78.201  37.295 65.441  1.00 43.34  ? 921  GLN D CB  1 
ATOM   6410 C CG  . GLN D 1 71  ? -77.193  38.331 65.940  1.00 45.92  ? 921  GLN D CG  1 
ATOM   6411 C CD  . GLN D 1 71  ? -75.768  38.032 65.490  1.00 46.13  ? 921  GLN D CD  1 
ATOM   6412 O OE1 . GLN D 1 71  ? -75.467  38.048 64.295  1.00 54.65  ? 921  GLN D OE1 1 
ATOM   6413 N NE2 . GLN D 1 71  ? -74.884  37.771 66.446  1.00 52.21  ? 921  GLN D NE2 1 
ATOM   6414 N N   . ALA D 1 72  ? -79.559  36.201 68.057  1.00 42.38  ? 922  ALA D N   1 
ATOM   6415 C CA  . ALA D 1 72  ? -79.458  36.022 69.496  1.00 44.58  ? 922  ALA D CA  1 
ATOM   6416 C C   . ALA D 1 72  ? -77.991  36.039 69.904  1.00 41.49  ? 922  ALA D C   1 
ATOM   6417 O O   . ALA D 1 72  ? -77.106  35.699 69.113  1.00 47.23  ? 922  ALA D O   1 
ATOM   6418 C CB  . ALA D 1 72  ? -80.126  34.719 69.938  1.00 44.72  ? 922  ALA D CB  1 
ATOM   6419 N N   . THR D 1 73  ? -77.738  36.453 71.143  1.00 38.26  ? 923  THR D N   1 
ATOM   6420 C CA  . THR D 1 73  ? -76.385  36.538 71.681  1.00 42.19  ? 923  THR D CA  1 
ATOM   6421 C C   . THR D 1 73  ? -76.226  35.525 72.804  1.00 38.57  ? 923  THR D C   1 
ATOM   6422 O O   . THR D 1 73  ? -76.830  35.659 73.873  1.00 38.76  ? 923  THR D O   1 
ATOM   6423 C CB  . THR D 1 73  ? -76.086  37.948 72.177  1.00 38.96  ? 923  THR D CB  1 
ATOM   6424 O OG1 . THR D 1 73  ? -76.256  38.874 71.098  1.00 39.49  ? 923  THR D OG1 1 
ATOM   6425 C CG2 . THR D 1 73  ? -74.664  38.043 72.701  1.00 40.08  ? 923  THR D CG2 1 
ATOM   6426 N N   . ILE D 1 74  ? -75.447  34.501 72.531  1.00 39.09  ? 924  ILE D N   1 
ATOM   6427 C CA  . ILE D 1 74  ? -75.089  33.475 73.490  1.00 41.37  ? 924  ILE D CA  1 
ATOM   6428 C C   . ILE D 1 74  ? -73.695  33.733 74.055  1.00 42.84  ? 924  ILE D C   1 
ATOM   6429 O O   . ILE D 1 74  ? -72.727  33.812 73.293  1.00 44.27  ? 924  ILE D O   1 
ATOM   6430 C CB  . ILE D 1 74  ? -75.155  32.108 72.816  1.00 46.46  ? 924  ILE D CB  1 
ATOM   6431 C CG1 . ILE D 1 74  ? -76.565  31.827 72.266  1.00 46.57  ? 924  ILE D CG1 1 
ATOM   6432 C CG2 . ILE D 1 74  ? -74.608  31.180 73.720  1.00 47.49  ? 924  ILE D CG2 1 
ATOM   6433 C CD1 . ILE D 1 74  ? -77.656  31.911 73.294  1.00 46.89  ? 924  ILE D CD1 1 
ATOM   6434 N N   . LEU D 1 75  ? -73.597  33.828 75.365  1.00 39.93  ? 925  LEU D N   1 
ATOM   6435 C CA  . LEU D 1 75  ? -72.276  34.158 75.930  1.00 39.63  ? 925  LEU D CA  1 
ATOM   6436 C C   . LEU D 1 75  ? -71.403  32.913 75.965  1.00 50.94  ? 925  LEU D C   1 
ATOM   6437 O O   . LEU D 1 75  ? -71.928  31.809 76.068  1.00 45.73  ? 925  LEU D O   1 
ATOM   6438 C CB  . LEU D 1 75  ? -72.423  34.728 77.337  1.00 39.92  ? 925  LEU D CB  1 
ATOM   6439 C CG  . LEU D 1 75  ? -73.282  35.976 77.504  1.00 45.96  ? 925  LEU D CG  1 
ATOM   6440 C CD1 . LEU D 1 75  ? -72.747  36.827 78.639  1.00 44.08  ? 925  LEU D CD1 1 
ATOM   6441 C CD2 . LEU D 1 75  ? -73.362  36.773 76.218  1.00 46.61  ? 925  LEU D CD2 1 
ATOM   6442 N N   . PRO D 1 76  ? -70.077  33.084 75.887  1.00 47.68  ? 926  PRO D N   1 
ATOM   6443 C CA  . PRO D 1 76  ? -69.175  31.973 76.042  1.00 50.28  ? 926  PRO D CA  1 
ATOM   6444 C C   . PRO D 1 76  ? -69.067  31.561 77.515  1.00 53.14  ? 926  PRO D C   1 
ATOM   6445 O O   . PRO D 1 76  ? -69.659  32.191 78.328  1.00 48.46  ? 926  PRO D O   1 
ATOM   6446 C CB  . PRO D 1 76  ? -67.848  32.584 75.574  1.00 49.88  ? 926  PRO D CB  1 
ATOM   6447 C CG  . PRO D 1 76  ? -68.210  33.856 74.861  1.00 51.35  ? 926  PRO D CG  1 
ATOM   6448 C CD  . PRO D 1 76  ? -69.417  34.350 75.616  1.00 47.56  ? 926  PRO D CD  1 
ATOM   6449 N N   . LYS D 1 77  ? -68.300  30.512 77.799  1.00 57.40  ? 927  LYS D N   1 
ATOM   6450 C CA  . LYS D 1 77  ? -68.139  29.974 79.174  1.00 56.20  ? 927  LYS D CA  1 
ATOM   6451 C C   . LYS D 1 77  ? -67.431  30.998 80.039  1.00 45.71  ? 927  LYS D C   1 
ATOM   6452 O O   . LYS D 1 77  ? -67.616  30.970 81.240  1.00 51.76  ? 927  LYS D O   1 
ATOM   6453 C CB  . LYS D 1 77  ? -67.323  28.680 79.089  1.00 59.23  ? 927  LYS D CB  1 
ATOM   6454 C CG  . LYS D 1 77  ? -66.176  28.703 78.089  1.00 60.93  ? 927  LYS D CG  1 
ATOM   6455 C CD  . LYS D 1 77  ? -65.341  27.438 78.089  1.00 60.90  ? 927  LYS D CD  1 
ATOM   6456 C CE  . LYS D 1 77  ? -66.010  26.257 77.418  1.00 66.81  ? 927  LYS D CE  1 
ATOM   6457 N NZ  . LYS D 1 77  ? -66.014  26.385 75.941  1.00 68.10  ? 927  LYS D NZ  1 
ATOM   6458 N N   . THR D 1 78  ? -66.667  31.875 79.407  1.00 54.30  ? 928  THR D N   1 
ATOM   6459 C CA  . THR D 1 78  ? -65.945  32.959 80.111  1.00 47.72  ? 928  THR D CA  1 
ATOM   6460 C C   . THR D 1 78  ? -66.943  33.905 80.784  1.00 45.29  ? 928  THR D C   1 
ATOM   6461 O O   . THR D 1 78  ? -66.525  34.631 81.682  1.00 44.97  ? 928  THR D O   1 
ATOM   6462 C CB  . THR D 1 78  ? -65.075  33.673 79.078  1.00 49.92  ? 928  THR D CB  1 
ATOM   6463 O OG1 . THR D 1 78  ? -65.920  34.115 78.020  1.00 51.42  ? 928  THR D OG1 1 
ATOM   6464 C CG2 . THR D 1 78  ? -63.992  32.778 78.521  1.00 56.58  ? 928  THR D CG2 1 
ATOM   6465 N N   . GLY D 1 79  ? -68.191  33.915 80.329  1.00 46.77  ? 929  GLY D N   1 
ATOM   6466 C CA  . GLY D 1 79  ? -69.247  34.733 80.957  1.00 46.52  ? 929  GLY D CA  1 
ATOM   6467 C C   . GLY D 1 79  ? -69.183  36.203 80.597  1.00 43.11  ? 929  GLY D C   1 
ATOM   6468 O O   . GLY D 1 79  ? -69.740  37.002 81.338  1.00 39.33  ? 929  GLY D O   1 
ATOM   6469 N N   . THR D 1 80  ? -68.565  36.516 79.468  1.00 37.98  ? 930  THR D N   1 
ATOM   6470 C CA  . THR D 1 80  ? -68.349  37.929 79.104  1.00 39.27  ? 930  THR D CA  1 
ATOM   6471 C C   . THR D 1 80  ? -68.908  38.246 77.716  1.00 38.07  ? 930  THR D C   1 
ATOM   6472 O O   . THR D 1 80  ? -68.928  37.367 76.862  1.00 37.21  ? 930  THR D O   1 
ATOM   6473 C CB  . THR D 1 80  ? -66.859  38.278 79.177  1.00 42.14  ? 930  THR D CB  1 
ATOM   6474 O OG1 . THR D 1 80  ? -66.177  37.537 78.167  1.00 43.64  ? 930  THR D OG1 1 
ATOM   6475 C CG2 . THR D 1 80  ? -66.264  37.998 80.537  1.00 44.34  ? 930  THR D CG2 1 
ATOM   6476 N N   . VAL D 1 81  ? -69.340  39.488 77.542  1.00 35.53  ? 931  VAL D N   1 
ATOM   6477 C CA  . VAL D 1 81  ? -69.814  39.953 76.217  1.00 35.06  ? 931  VAL D CA  1 
ATOM   6478 C C   . VAL D 1 81  ? -69.527  41.451 76.111  1.00 30.73  ? 931  VAL D C   1 
ATOM   6479 O O   . VAL D 1 81  ? -69.611  42.147 77.124  1.00 34.07  ? 931  VAL D O   1 
ATOM   6480 C CB  . VAL D 1 81  ? -71.306  39.669 75.981  1.00 38.27  ? 931  VAL D CB  1 
ATOM   6481 C CG1 . VAL D 1 81  ? -72.195  40.525 76.865  1.00 36.78  ? 931  VAL D CG1 1 
ATOM   6482 C CG2 . VAL D 1 81  ? -71.684  39.836 74.521  1.00 43.07  ? 931  VAL D CG2 1 
ATOM   6483 N N   . SER D 1 82  ? -69.217  41.899 74.914  1.00 35.81  ? 932  SER D N   1 
ATOM   6484 C CA  . SER D 1 82  ? -69.008  43.318 74.652  1.00 31.93  ? 932  SER D CA  1 
ATOM   6485 C C   . SER D 1 82  ? -70.029  43.762 73.614  1.00 30.84  ? 932  SER D C   1 
ATOM   6486 O O   . SER D 1 82  ? -70.000  43.290 72.473  1.00 31.97  ? 932  SER D O   1 
ATOM   6487 C CB  . SER D 1 82  ? -67.580  43.582 74.171  1.00 36.78  ? 932  SER D CB  1 
ATOM   6488 O OG  . SER D 1 82  ? -67.365  44.958 73.915  1.00 37.12  ? 932  SER D OG  1 
ATOM   6489 N N   . LEU D 1 83  ? -70.936  44.651 74.011  1.00 30.97  ? 933  LEU D N   1 
ATOM   6490 C CA  . LEU D 1 83  ? -72.022  45.098 73.145  1.00 30.23  ? 933  LEU D CA  1 
ATOM   6491 C C   . LEU D 1 83  ? -71.861  46.583 72.865  1.00 27.48  ? 933  LEU D C   1 
ATOM   6492 O O   . LEU D 1 83  ? -71.727  47.378 73.795  1.00 28.90  ? 933  LEU D O   1 
ATOM   6493 C CB  . LEU D 1 83  ? -73.381  44.824 73.791  1.00 27.86  ? 933  LEU D CB  1 
ATOM   6494 C CG  . LEU D 1 83  ? -73.696  43.341 73.980  1.00 31.36  ? 933  LEU D CG  1 
ATOM   6495 C CD1 . LEU D 1 83  ? -74.942  43.157 74.827  1.00 34.75  ? 933  LEU D CD1 1 
ATOM   6496 C CD2 . LEU D 1 83  ? -73.853  42.656 72.632  1.00 33.72  ? 933  LEU D CD2 1 
ATOM   6497 N N   . GLU D 1 84  ? -71.851  46.963 71.594  1.00 28.63  ? 934  GLU D N   1 
ATOM   6498 C CA  . GLU D 1 84  ? -71.715  48.367 71.237  1.00 25.66  ? 934  GLU D CA  1 
ATOM   6499 C C   . GLU D 1 84  ? -73.055  48.917 70.767  1.00 28.23  ? 934  GLU D C   1 
ATOM   6500 O O   . GLU D 1 84  ? -73.754  48.274 69.983  1.00 27.87  ? 934  GLU D O   1 
ATOM   6501 C CB  . GLU D 1 84  ? -70.643  48.566 70.166  1.00 29.07  ? 934  GLU D CB  1 
ATOM   6502 C CG  . GLU D 1 84  ? -70.660  49.960 69.597  1.00 27.56  ? 934  GLU D CG  1 
ATOM   6503 C CD  . GLU D 1 84  ? -69.508  50.244 68.673  1.00 35.88  ? 934  GLU D CD  1 
ATOM   6504 O OE1 . GLU D 1 84  ? -68.531  49.463 68.640  1.00 41.65  ? 934  GLU D OE1 1 
ATOM   6505 O OE2 . GLU D 1 84  ? -69.610  51.255 67.960  1.00 34.16  ? 934  GLU D OE2 1 
ATOM   6506 N N   . VAL D 1 85  ? -73.414  50.097 71.265  1.00 25.51  ? 935  VAL D N   1 
ATOM   6507 C CA  . VAL D 1 85  ? -74.590  50.833 70.821  1.00 26.09  ? 935  VAL D CA  1 
ATOM   6508 C C   . VAL D 1 85  ? -74.112  52.051 70.048  1.00 27.07  ? 935  VAL D C   1 
ATOM   6509 O O   . VAL D 1 85  ? -73.256  52.801 70.531  1.00 27.22  ? 935  VAL D O   1 
ATOM   6510 C CB  . VAL D 1 85  ? -75.471  51.268 72.005  1.00 26.58  ? 935  VAL D CB  1 
ATOM   6511 C CG1 . VAL D 1 85  ? -76.664  52.079 71.505  1.00 26.03  ? 935  VAL D CG1 1 
ATOM   6512 C CG2 . VAL D 1 85  ? -75.909  50.067 72.830  1.00 26.82  ? 935  VAL D CG2 1 
ATOM   6513 N N   . ARG D 1 86  ? -74.669  52.255 68.860  1.00 25.11  ? 936  ARG D N   1 
ATOM   6514 C CA  . ARG D 1 86  ? -74.405  53.436 68.052  1.00 25.54  ? 936  ARG D CA  1 
ATOM   6515 C C   . ARG D 1 86  ? -75.714  54.178 67.839  1.00 27.35  ? 936  ARG D C   1 
ATOM   6516 O O   . ARG D 1 86  ? -76.729  53.559 67.505  1.00 26.87  ? 936  ARG D O   1 
ATOM   6517 C CB  . ARG D 1 86  ? -73.796  53.063 66.696  1.00 27.65  ? 936  ARG D CB  1 
ATOM   6518 C CG  . ARG D 1 86  ? -72.374  52.533 66.752  1.00 27.98  ? 936  ARG D CG  1 
ATOM   6519 C CD  . ARG D 1 86  ? -71.866  52.176 65.357  1.00 26.86  ? 936  ARG D CD  1 
ATOM   6520 N NE  . ARG D 1 86  ? -72.639  51.105 64.737  1.00 29.50  ? 936  ARG D NE  1 
ATOM   6521 C CZ  . ARG D 1 86  ? -72.423  49.813 64.940  1.00 31.11  ? 936  ARG D CZ  1 
ATOM   6522 N NH1 . ARG D 1 86  ? -71.456  49.391 65.738  1.00 31.46  ? 936  ARG D NH1 1 
ATOM   6523 N NH2 . ARG D 1 86  ? -73.198  48.921 64.328  1.00 29.03  ? 936  ARG D NH2 1 
ATOM   6524 N N   . LEU D 1 87  ? -75.691  55.497 68.018  1.00 25.89  ? 937  LEU D N   1 
ATOM   6525 C CA  . LEU D 1 87  ? -76.828  56.343 67.679  1.00 26.49  ? 937  LEU D CA  1 
ATOM   6526 C C   . LEU D 1 87  ? -76.530  57.020 66.349  1.00 26.49  ? 937  LEU D C   1 
ATOM   6527 O O   . LEU D 1 87  ? -75.523  57.725 66.225  1.00 28.02  ? 937  LEU D O   1 
ATOM   6528 C CB  . LEU D 1 87  ? -77.084  57.382 68.771  1.00 27.33  ? 937  LEU D CB  1 
ATOM   6529 C CG  . LEU D 1 87  ? -77.352  56.816 70.166  1.00 26.95  ? 937  LEU D CG  1 
ATOM   6530 C CD1 . LEU D 1 87  ? -77.719  57.927 71.135  1.00 27.01  ? 937  LEU D CD1 1 
ATOM   6531 C CD2 . LEU D 1 87  ? -78.453  55.769 70.101  1.00 30.52  ? 937  LEU D CD2 1 
ATOM   6532 N N   . LEU D 1 88  ? -77.395  56.810 65.358  1.00 26.65  ? 938  LEU D N   1 
ATOM   6533 C CA  . LEU D 1 88  ? -77.107  57.328 64.028  1.00 27.65  ? 938  LEU D CA  1 
ATOM   6534 C C   . LEU D 1 88  ? -77.182  58.852 64.019  1.00 31.20  ? 938  LEU D C   1 
ATOM   6535 O O   . LEU D 1 88  ? -77.945  59.466 64.769  1.00 29.43  ? 938  LEU D O   1 
ATOM   6536 C CB  . LEU D 1 88  ? -78.067  56.741 62.988  1.00 28.62  ? 938  LEU D CB  1 
ATOM   6537 C CG  . LEU D 1 88  ? -77.678  55.385 62.377  1.00 33.69  ? 938  LEU D CG  1 
ATOM   6538 C CD1 . LEU D 1 88  ? -77.763  54.257 63.403  1.00 30.38  ? 938  LEU D CD1 1 
ATOM   6539 C CD2 . LEU D 1 88  ? -78.493  55.053 61.126  1.00 35.54  ? 938  LEU D CD2 1 
ATOM   6540 N N   . GLU D 1 89  ? -76.366  59.455 63.157  1.00 28.27  ? 939  GLU D N   1 
ATOM   6541 C CA  . GLU D 1 89  ? -76.283  60.907 63.049  1.00 25.39  ? 939  GLU D CA  1 
ATOM   6542 C C   . GLU D 1 89  ? -77.627  61.526 62.691  1.00 26.97  ? 939  GLU D C   1 
ATOM   6543 O O   . GLU D 1 89  ? -78.282  61.095 61.738  1.00 29.51  ? 939  GLU D O   1 
ATOM   6544 C CB  . GLU D 1 89  ? -75.273  61.273 61.967  1.00 25.11  ? 939  GLU D CB  1 
ATOM   6545 C CG  . GLU D 1 89  ? -74.853  62.721 61.943  1.00 28.46  ? 939  GLU D CG  1 
ATOM   6546 C CD  . GLU D 1 89  ? -73.905  62.998 60.797  1.00 33.81  ? 939  GLU D CD  1 
ATOM   6547 O OE1 . GLU D 1 89  ? -74.253  62.634 59.653  1.00 32.49  ? 939  GLU D OE1 1 
ATOM   6548 O OE2 . GLU D 1 89  ? -72.821  63.567 61.032  1.00 30.68  ? 939  GLU D OE2 1 
ATOM   6549 N N   . ALA D 1 90  ? -78.015  62.568 63.435  1.00 27.97  ? 940  ALA D N   1 
ATOM   6550 C CA  . ALA D 1 90  ? -79.187  63.384 63.103  1.00 29.35  ? 940  ALA D CA  1 
ATOM   6551 C C   . ALA D 1 90  ? -80.419  62.514 62.863  1.00 30.84  ? 940  ALA D C   1 
ATOM   6552 O O   . ALA D 1 90  ? -81.160  62.695 61.895  1.00 30.23  ? 940  ALA D O   1 
ATOM   6553 C CB  . ALA D 1 90  ? -78.903  64.283 61.898  1.00 28.35  ? 940  ALA D CB  1 
ATOM   6554 N N   . SER D 1 91  ? -80.610  61.533 63.740  1.00 30.61  ? 941  SER D N   1 
ATOM   6555 C CA  . SER D 1 91  ? -81.616  60.499 63.553  1.00 29.90  ? 941  SER D CA  1 
ATOM   6556 C C   . SER D 1 91  ? -81.963  59.901 64.907  1.00 31.34  ? 941  SER D C   1 
ATOM   6557 O O   . SER D 1 91  ? -81.184  59.990 65.859  1.00 28.23  ? 941  SER D O   1 
ATOM   6558 C CB  . SER D 1 91  ? -81.109  59.410 62.601  1.00 29.40  ? 941  SER D CB  1 
ATOM   6559 O OG  . SER D 1 91  ? -82.014  58.326 62.520  1.00 28.71  ? 941  SER D OG  1 
ATOM   6560 N N   . ARG D 1 92  ? -83.142  59.283 64.981  1.00 30.67  ? 942  ARG D N   1 
ATOM   6561 C CA  . ARG D 1 92  ? -83.500  58.494 66.152  1.00 30.80  ? 942  ARG D CA  1 
ATOM   6562 C C   . ARG D 1 92  ? -83.030  57.052 66.054  1.00 29.96  ? 942  ARG D C   1 
ATOM   6563 O O   . ARG D 1 92  ? -83.137  56.315 67.040  1.00 31.30  ? 942  ARG D O   1 
ATOM   6564 C CB  . ARG D 1 92  ? -85.018  58.481 66.364  1.00 28.81  ? 942  ARG D CB  1 
ATOM   6565 C CG  . ARG D 1 92  ? -85.629  59.799 66.774  1.00 31.10  ? 942  ARG D CG  1 
ATOM   6566 C CD  . ARG D 1 92  ? -87.142  59.732 66.641  1.00 29.93  ? 942  ARG D CD  1 
ATOM   6567 N NE  . ARG D 1 92  ? -87.793  60.909 67.199  1.00 35.42  ? 942  ARG D NE  1 
ATOM   6568 C CZ  . ARG D 1 92  ? -89.106  61.096 67.225  1.00 33.09  ? 942  ARG D CZ  1 
ATOM   6569 N NH1 . ARG D 1 92  ? -89.940  60.211 66.705  1.00 32.54  ? 942  ARG D NH1 1 
ATOM   6570 N NH2 . ARG D 1 92  ? -89.591  62.211 67.762  1.00 34.49  ? 942  ARG D NH2 1 
ATOM   6571 N N   . ALA D 1 93  ? -82.502  56.641 64.905  1.00 29.29  ? 943  ALA D N   1 
ATOM   6572 C CA  . ALA D 1 93  ? -82.137  55.249 64.702  1.00 26.82  ? 943  ALA D CA  1 
ATOM   6573 C C   . ALA D 1 93  ? -80.946  54.856 65.568  1.00 28.25  ? 943  ALA D C   1 
ATOM   6574 O O   . ALA D 1 93  ? -80.055  55.664 65.856  1.00 28.69  ? 943  ALA D O   1 
ATOM   6575 C CB  . ALA D 1 93  ? -81.822  54.991 63.229  1.00 24.70  ? 943  ALA D CB  1 
ATOM   6576 N N   . PHE D 1 94  ? -80.933  53.589 65.978  1.00 27.39  ? 944  PHE D N   1 
ATOM   6577 C CA  . PHE D 1 94  ? -79.832  53.046 66.755  1.00 27.94  ? 944  PHE D CA  1 
ATOM   6578 C C   . PHE D 1 94  ? -79.449  51.681 66.205  1.00 26.68  ? 944  PHE D C   1 
ATOM   6579 O O   . PHE D 1 94  ? -80.221  51.027 65.498  1.00 27.86  ? 944  PHE D O   1 
ATOM   6580 C CB  . PHE D 1 94  ? -80.174  52.933 68.251  1.00 26.44  ? 944  PHE D CB  1 
ATOM   6581 C CG  . PHE D 1 94  ? -81.208  51.886 68.567  1.00 28.39  ? 944  PHE D CG  1 
ATOM   6582 C CD1 . PHE D 1 94  ? -80.837  50.567 68.790  1.00 26.96  ? 944  PHE D CD1 1 
ATOM   6583 C CD2 . PHE D 1 94  ? -82.547  52.222 68.661  1.00 29.00  ? 944  PHE D CD2 1 
ATOM   6584 C CE1 . PHE D 1 94  ? -81.781  49.603 69.079  1.00 29.08  ? 944  PHE D CE1 1 
ATOM   6585 C CE2 . PHE D 1 94  ? -83.497  51.261 68.957  1.00 30.03  ? 944  PHE D CE2 1 
ATOM   6586 C CZ  . PHE D 1 94  ? -83.113  49.951 69.164  1.00 29.35  ? 944  PHE D CZ  1 
ATOM   6587 N N   . GLU D 1 95  ? -78.237  51.261 66.551  1.00 26.55  ? 945  GLU D N   1 
ATOM   6588 C CA  . GLU D 1 95  ? -77.736  49.931 66.245  1.00 27.68  ? 945  GLU D CA  1 
ATOM   6589 C C   . GLU D 1 95  ? -77.067  49.362 67.484  1.00 23.90  ? 945  GLU D C   1 
ATOM   6590 O O   . GLU D 1 95  ? -76.441  50.096 68.252  1.00 27.99  ? 945  GLU D O   1 
ATOM   6591 C CB  . GLU D 1 95  ? -76.732  49.954 65.080  1.00 26.57  ? 945  GLU D CB  1 
ATOM   6592 C CG  . GLU D 1 95  ? -77.341  50.293 63.731  1.00 28.03  ? 945  GLU D CG  1 
ATOM   6593 C CD  . GLU D 1 95  ? -76.306  50.717 62.702  1.00 37.05  ? 945  GLU D CD  1 
ATOM   6594 O OE1 . GLU D 1 95  ? -75.094  50.533 62.950  1.00 30.37  ? 945  GLU D OE1 1 
ATOM   6595 O OE2 . GLU D 1 95  ? -76.709  51.244 61.645  1.00 30.88  ? 945  GLU D OE2 1 
ATOM   6596 N N   . VAL D 1 96  ? -77.210  48.057 67.679  1.00 28.48  ? 946  VAL D N   1 
ATOM   6597 C CA  . VAL D 1 96  ? -76.461  47.309 68.679  1.00 26.68  ? 946  VAL D CA  1 
ATOM   6598 C C   . VAL D 1 96  ? -75.667  46.260 67.923  1.00 28.86  ? 946  VAL D C   1 
ATOM   6599 O O   . VAL D 1 96  ? -76.221  45.568 67.070  1.00 29.63  ? 946  VAL D O   1 
ATOM   6600 C CB  . VAL D 1 96  ? -77.391  46.650 69.715  1.00 29.15  ? 946  VAL D CB  1 
ATOM   6601 C CG1 . VAL D 1 96  ? -76.590  45.844 70.734  1.00 29.18  ? 946  VAL D CG1 1 
ATOM   6602 C CG2 . VAL D 1 96  ? -78.249  47.696 70.400  1.00 27.03  ? 946  VAL D CG2 1 
ATOM   6603 N N   . SER D 1 97  ? -74.375  46.161 68.200  1.00 27.22  ? 947  SER D N   1 
ATOM   6604 C CA  . SER D 1 97  ? -73.540  45.199 67.503  1.00 27.99  ? 947  SER D CA  1 
ATOM   6605 C C   . SER D 1 97  ? -72.694  44.432 68.504  1.00 28.18  ? 947  SER D C   1 
ATOM   6606 O O   . SER D 1 97  ? -72.442  44.884 69.626  1.00 31.84  ? 947  SER D O   1 
ATOM   6607 C CB  . SER D 1 97  ? -72.621  45.860 66.465  1.00 30.99  ? 947  SER D CB  1 
ATOM   6608 O OG  . SER D 1 97  ? -71.753  46.796 67.075  1.00 33.47  ? 947  SER D OG  1 
ATOM   6609 N N   . GLU D 1 98  ? -72.282  43.245 68.078  1.00 31.53  ? 948  GLU D N   1 
ATOM   6610 C CA  . GLU D 1 98  ? -71.331  42.435 68.824  1.00 34.02  ? 948  GLU D CA  1 
ATOM   6611 C C   . GLU D 1 98  ? -70.310  41.907 67.830  1.00 38.28  ? 948  GLU D C   1 
ATOM   6612 O O   . GLU D 1 98  ? -70.679  41.221 66.871  1.00 38.38  ? 948  GLU D O   1 
ATOM   6613 C CB  . GLU D 1 98  ? -72.043  41.300 69.563  1.00 35.66  ? 948  GLU D CB  1 
ATOM   6614 C CG  . GLU D 1 98  ? -71.192  40.628 70.613  1.00 43.84  ? 948  GLU D CG  1 
ATOM   6615 C CD  . GLU D 1 98  ? -71.141  39.128 70.456  1.00 51.50  ? 948  GLU D CD  1 
ATOM   6616 O OE1 . GLU D 1 98  ? -71.749  38.603 69.500  1.00 53.57  ? 948  GLU D OE1 1 
ATOM   6617 O OE2 . GLU D 1 98  ? -70.493  38.473 71.298  1.00 53.82  ? 948  GLU D OE2 1 
ATOM   6618 N N   . ASN D 1 99  ? -69.034  42.221 68.062  1.00 41.50  ? 949  ASN D N   1 
ATOM   6619 C CA  . ASN D 1 99  ? -67.962  41.888 67.120  1.00 41.65  ? 949  ASN D CA  1 
ATOM   6620 C C   . ASN D 1 99  ? -68.267  42.421 65.724  1.00 42.53  ? 949  ASN D C   1 
ATOM   6621 O O   . ASN D 1 99  ? -67.979  41.775 64.715  1.00 48.17  ? 949  ASN D O   1 
ATOM   6622 C CB  . ASN D 1 99  ? -67.706  40.382 67.064  1.00 48.18  ? 949  ASN D CB  1 
ATOM   6623 C CG  . ASN D 1 99  ? -67.063  39.853 68.320  1.00 54.35  ? 949  ASN D CG  1 
ATOM   6624 O OD1 . ASN D 1 99  ? -65.964  40.267 68.689  1.00 61.10  ? 949  ASN D OD1 1 
ATOM   6625 N ND2 . ASN D 1 99  ? -67.737  38.922 68.982  1.00 54.44  ? 949  ASN D ND2 1 
ATOM   6626 N N   . GLY D 1 100 ? -68.885  43.599 65.654  1.00 36.66  ? 950  GLY D N   1 
ATOM   6627 C CA  . GLY D 1 100 ? -69.221  44.161 64.366  1.00 42.67  ? 950  GLY D CA  1 
ATOM   6628 C C   . GLY D 1 100 ? -70.483  43.610 63.745  1.00 46.63  ? 950  GLY D C   1 
ATOM   6629 O O   . GLY D 1 100 ? -70.943  44.155 62.733  1.00 47.13  ? 950  GLY D O   1 
ATOM   6630 N N   . ASN D 1 101 ? -71.022  42.513 64.275  1.00 42.66  ? 951  ASN D N   1 
ATOM   6631 C CA  . ASN D 1 101 ? -72.245  41.924 63.750  1.00 38.47  ? 951  ASN D CA  1 
ATOM   6632 C C   . ASN D 1 101 ? -73.451  42.684 64.280  1.00 35.59  ? 951  ASN D C   1 
ATOM   6633 O O   . ASN D 1 101 ? -73.542  42.948 65.482  1.00 34.24  ? 951  ASN D O   1 
ATOM   6634 C CB  . ASN D 1 101 ? -72.343  40.459 64.169  1.00 41.13  ? 951  ASN D CB  1 
ATOM   6635 C CG  . ASN D 1 101 ? -71.345  39.581 63.456  1.00 55.45  ? 951  ASN D CG  1 
ATOM   6636 O OD1 . ASN D 1 101 ? -70.735  39.990 62.470  1.00 54.91  ? 951  ASN D OD1 1 
ATOM   6637 N ND2 . ASN D 1 101 ? -71.159  38.368 63.962  1.00 54.35  ? 951  ASN D ND2 1 
ATOM   6638 N N   . LEU D 1 102 ? -74.388  43.010 63.395  1.00 32.64  ? 952  LEU D N   1 
ATOM   6639 C CA  . LEU D 1 102 ? -75.584  43.721 63.822  1.00 35.69  ? 952  LEU D CA  1 
ATOM   6640 C C   . LEU D 1 102 ? -76.497  42.787 64.609  1.00 33.85  ? 952  LEU D C   1 
ATOM   6641 O O   . LEU D 1 102 ? -76.888  41.725 64.116  1.00 35.98  ? 952  LEU D O   1 
ATOM   6642 C CB  . LEU D 1 102 ? -76.331  44.282 62.614  1.00 33.81  ? 952  LEU D CB  1 
ATOM   6643 C CG  . LEU D 1 102 ? -77.530  45.158 62.973  1.00 35.90  ? 952  LEU D CG  1 
ATOM   6644 C CD1 . LEU D 1 102 ? -77.072  46.428 63.678  1.00 36.06  ? 952  LEU D CD1 1 
ATOM   6645 C CD2 . LEU D 1 102 ? -78.357  45.477 61.740  1.00 34.23  ? 952  LEU D CD2 1 
ATOM   6646 N N   . VAL D 1 103 ? -76.859  43.194 65.822  1.00 29.73  ? 953  VAL D N   1 
ATOM   6647 C CA  . VAL D 1 103 ? -77.725  42.422 66.696  1.00 29.28  ? 953  VAL D CA  1 
ATOM   6648 C C   . VAL D 1 103 ? -79.116  43.036 66.783  1.00 34.68  ? 953  VAL D C   1 
ATOM   6649 O O   . VAL D 1 103 ? -80.117  42.322 66.689  1.00 31.13  ? 953  VAL D O   1 
ATOM   6650 C CB  . VAL D 1 103 ? -77.096  42.291 68.103  1.00 32.57  ? 953  VAL D CB  1 
ATOM   6651 C CG1 . VAL D 1 103 ? -78.009  41.504 69.038  1.00 33.60  ? 953  VAL D CG1 1 
ATOM   6652 C CG2 . VAL D 1 103 ? -75.716  41.651 68.027  1.00 36.10  ? 953  VAL D CG2 1 
ATOM   6653 N N   . VAL D 1 104 ? -79.202  44.360 66.933  1.00 28.95  ? 954  VAL D N   1 
ATOM   6654 C CA  . VAL D 1 104 ? -80.477  45.060 67.070  1.00 28.64  ? 954  VAL D CA  1 
ATOM   6655 C C   . VAL D 1 104 ? -80.435  46.343 66.254  1.00 32.82  ? 954  VAL D C   1 
ATOM   6656 O O   . VAL D 1 104 ? -79.407  47.025 66.197  1.00 30.32  ? 954  VAL D O   1 
ATOM   6657 C CB  . VAL D 1 104 ? -80.802  45.406 68.541  1.00 30.80  ? 954  VAL D CB  1 
ATOM   6658 C CG1 . VAL D 1 104 ? -82.235  45.927 68.666  1.00 31.58  ? 954  VAL D CG1 1 
ATOM   6659 C CG2 . VAL D 1 104 ? -80.567  44.219 69.461  1.00 31.62  ? 954  VAL D CG2 1 
ATOM   6660 N N   . SER D 1 105 ? -81.564  46.678 65.633  1.00 28.44  ? 955  SER D N   1 
ATOM   6661 C CA  . SER D 1 105 ? -81.765  47.994 65.050  1.00 28.68  ? 955  SER D CA  1 
ATOM   6662 C C   . SER D 1 105 ? -83.162  48.475 65.412  1.00 31.72  ? 955  SER D C   1 
ATOM   6663 O O   . SER D 1 105 ? -84.018  47.698 65.841  1.00 30.65  ? 955  SER D O   1 
ATOM   6664 C CB  . SER D 1 105 ? -81.577  47.984 63.527  1.00 32.78  ? 955  SER D CB  1 
ATOM   6665 O OG  . SER D 1 105 ? -82.463  47.070 62.906  1.00 36.02  ? 955  SER D OG  1 
ATOM   6666 N N   . GLY D 1 106 ? -83.386  49.767 65.227  1.00 30.04  ? 956  GLY D N   1 
ATOM   6667 C CA  . GLY D 1 106 ? -84.655  50.368 65.577  1.00 32.70  ? 956  GLY D CA  1 
ATOM   6668 C C   . GLY D 1 106 ? -84.479  51.855 65.807  1.00 32.71  ? 956  GLY D C   1 
ATOM   6669 O O   . GLY D 1 106 ? -83.460  52.441 65.450  1.00 29.77  ? 956  GLY D O   1 
ATOM   6670 N N   . LYS D 1 107 ? -85.492  52.445 66.432  1.00 28.41  ? 957  LYS D N   1 
ATOM   6671 C CA  . LYS D 1 107 ? -85.496  53.861 66.750  1.00 27.69  ? 957  LYS D CA  1 
ATOM   6672 C C   . LYS D 1 107 ? -85.729  54.009 68.245  1.00 29.34  ? 957  LYS D C   1 
ATOM   6673 O O   . LYS D 1 107 ? -86.443  53.212 68.855  1.00 31.08  ? 957  LYS D O   1 
ATOM   6674 C CB  . LYS D 1 107 ? -86.574  54.616 65.952  1.00 33.21  ? 957  LYS D CB  1 
ATOM   6675 C CG  . LYS D 1 107 ? -86.317  54.655 64.445  1.00 36.08  ? 957  LYS D CG  1 
ATOM   6676 C CD  . LYS D 1 107 ? -87.411  55.412 63.694  1.00 45.04  ? 957  LYS D CD  1 
ATOM   6677 C CE  . LYS D 1 107 ? -87.690  54.815 62.314  1.00 45.14  ? 957  LYS D CE  1 
ATOM   6678 N NZ  . LYS D 1 107 ? -88.187  53.410 62.343  1.00 42.53  ? 957  LYS D NZ  1 
ATOM   6679 N N   . VAL D 1 108 ? -85.112  55.028 68.832  1.00 27.38  ? 958  VAL D N   1 
ATOM   6680 C CA  . VAL D 1 108 ? -85.251  55.308 70.255  1.00 30.97  ? 958  VAL D CA  1 
ATOM   6681 C C   . VAL D 1 108 ? -85.274  56.820 70.424  1.00 35.02  ? 958  VAL D C   1 
ATOM   6682 O O   . VAL D 1 108 ? -84.545  57.541 69.734  1.00 32.74  ? 958  VAL D O   1 
ATOM   6683 C CB  . VAL D 1 108 ? -84.109  54.646 71.068  1.00 29.05  ? 958  VAL D CB  1 
ATOM   6684 C CG1 . VAL D 1 108 ? -82.763  55.335 70.820  1.00 28.65  ? 958  VAL D CG1 1 
ATOM   6685 C CG2 . VAL D 1 108 ? -84.440  54.595 72.552  1.00 31.34  ? 958  VAL D CG2 1 
ATOM   6686 N N   . TYR D 1 109 ? -86.151  57.288 71.298  1.00 27.60  ? 959  TYR D N   1 
ATOM   6687 C CA  . TYR D 1 109 ? -86.226  58.745 71.513  1.00 29.11  ? 959  TYR D CA  1 
ATOM   6688 C C   . TYR D 1 109 ? -86.800  59.130 72.881  1.00 34.76  ? 959  TYR D C   1 
ATOM   6689 O O   . TYR D 1 109 ? -87.552  58.369 73.459  1.00 33.30  ? 959  TYR D O   1 
ATOM   6690 C CB  . TYR D 1 109 ? -86.996  59.426 70.380  1.00 31.76  ? 959  TYR D CB  1 
ATOM   6691 C CG  . TYR D 1 109 ? -88.425  59.010 70.144  1.00 30.43  ? 959  TYR D CG  1 
ATOM   6692 C CD1 . TYR D 1 109 ? -88.733  57.912 69.362  1.00 31.54  ? 959  TYR D CD1 1 
ATOM   6693 C CD2 . TYR D 1 109 ? -89.473  59.753 70.658  1.00 37.13  ? 959  TYR D CD2 1 
ATOM   6694 C CE1 . TYR D 1 109 ? -90.043  57.545 69.118  1.00 32.36  ? 959  TYR D CE1 1 
ATOM   6695 C CE2 . TYR D 1 109 ? -90.789  59.402 70.421  1.00 35.77  ? 959  TYR D CE2 1 
ATOM   6696 C CZ  . TYR D 1 109 ? -91.075  58.292 69.652  1.00 36.62  ? 959  TYR D CZ  1 
ATOM   6697 O OH  . TYR D 1 109 ? -92.374  57.943 69.421  1.00 35.91  ? 959  TYR D OH  1 
ATOM   6698 N N   . GLN D 1 110 ? -86.408  60.297 73.352  1.00 30.17  ? 960  GLN D N   1 
ATOM   6699 C CA  . GLN D 1 110 ? -86.952  60.836 74.614  1.00 31.27  ? 960  GLN D CA  1 
ATOM   6700 C C   . GLN D 1 110 ? -88.459  61.030 74.457  1.00 39.25  ? 960  GLN D C   1 
ATOM   6701 O O   . GLN D 1 110 ? -88.882  61.565 73.442  1.00 34.73  ? 960  GLN D O   1 
ATOM   6702 C CB  . GLN D 1 110 ? -86.306  62.173 74.953  1.00 36.40  ? 960  GLN D CB  1 
ATOM   6703 C CG  . GLN D 1 110 ? -86.703  62.754 76.297  1.00 38.29  ? 960  GLN D CG  1 
ATOM   6704 C CD  . GLN D 1 110 ? -85.873  63.971 76.616  1.00 41.86  ? 960  GLN D CD  1 
ATOM   6705 O OE1 . GLN D 1 110 ? -85.142  64.484 75.778  1.00 52.17  ? 960  GLN D OE1 1 
ATOM   6706 N NE2 . GLN D 1 110 ? -85.994  64.458 77.836  1.00 51.15  ? 960  GLN D NE2 1 
ATOM   6707 N N   . TRP D 1 111 ? -89.212  60.592 75.446  1.00 33.58  ? 961  TRP D N   1 
ATOM   6708 C CA  . TRP D 1 111 ? -90.675  60.780 75.424  1.00 34.35  ? 961  TRP D CA  1 
ATOM   6709 C C   . TRP D 1 111 ? -90.988  62.127 76.064  1.00 39.96  ? 961  TRP D C   1 
ATOM   6710 O O   . TRP D 1 111 ? -90.793  62.278 77.258  1.00 40.56  ? 961  TRP D O   1 
ATOM   6711 C CB  . TRP D 1 111 ? -91.354  59.622 76.145  1.00 38.55  ? 961  TRP D CB  1 
ATOM   6712 C CG  . TRP D 1 111 ? -92.835  59.514 76.003  1.00 38.44  ? 961  TRP D CG  1 
ATOM   6713 C CD1 . TRP D 1 111 ? -93.656  60.261 75.215  1.00 41.73  ? 961  TRP D CD1 1 
ATOM   6714 C CD2 . TRP D 1 111 ? -93.680  58.593 76.708  1.00 36.94  ? 961  TRP D CD2 1 
ATOM   6715 N NE1 . TRP D 1 111 ? -94.952  59.856 75.371  1.00 42.34  ? 961  TRP D NE1 1 
ATOM   6716 C CE2 . TRP D 1 111 ? -94.998  58.839 76.284  1.00 40.74  ? 961  TRP D CE2 1 
ATOM   6717 C CE3 . TRP D 1 111 ? -93.447  57.587 77.649  1.00 39.99  ? 961  TRP D CE3 1 
ATOM   6718 C CZ2 . TRP D 1 111 ? -96.080  58.113 76.772  1.00 41.23  ? 961  TRP D CZ2 1 
ATOM   6719 C CZ3 . TRP D 1 111 ? -94.516  56.870 78.130  1.00 40.99  ? 961  TRP D CZ3 1 
ATOM   6720 C CH2 . TRP D 1 111 ? -95.813  57.134 77.698  1.00 42.20  ? 961  TRP D CH2 1 
ATOM   6721 N N   . ASP D 1 112 ? -91.425  63.064 75.251  1.00 41.12  ? 962  ASP D N   1 
ATOM   6722 C CA  . ASP D 1 112 ? -91.793  64.391 75.775  1.00 49.54  ? 962  ASP D CA  1 
ATOM   6723 C C   . ASP D 1 112 ? -93.229  64.325 76.298  1.00 48.59  ? 962  ASP D C   1 
ATOM   6724 O O   . ASP D 1 112 ? -94.061  63.683 75.675  1.00 52.11  ? 962  ASP D O   1 
ATOM   6725 C CB  . ASP D 1 112 ? -91.596  65.469 74.713  1.00 50.41  ? 962  ASP D CB  1 
ATOM   6726 C CG  . ASP D 1 112 ? -90.188  65.555 74.164  1.00 58.55  ? 962  ASP D CG  1 
ATOM   6727 O OD1 . ASP D 1 112 ? -89.252  65.671 74.970  1.00 59.10  ? 962  ASP D OD1 1 
ATOM   6728 O OD2 . ASP D 1 112 ? -90.049  65.548 72.930  1.00 69.98  ? 962  ASP D OD2 1 
ATOM   6729 N N   . ASP D 1 113 ? -93.471  64.949 77.430  1.00 54.69  ? 963  ASP D N   1 
ATOM   6730 C CA  . ASP D 1 113 ? -94.829  64.957 78.040  1.00 56.42  ? 963  ASP D CA  1 
ATOM   6731 C C   . ASP D 1 113 ? -95.344  63.521 78.129  1.00 55.73  ? 963  ASP D C   1 
ATOM   6732 O O   . ASP D 1 113 ? -96.359  63.201 77.512  1.00 54.78  ? 963  ASP D O   1 
ATOM   6733 C CB  . ASP D 1 113 ? -95.753  65.953 77.335  1.00 60.52  ? 963  ASP D CB  1 
ATOM   6734 C CG  . ASP D 1 113 ? -96.374  65.468 76.036  1.00 70.34  ? 963  ASP D CG  1 
ATOM   6735 O OD1 . ASP D 1 113 ? -95.699  65.550 74.993  1.00 74.39  ? 963  ASP D OD1 1 
ATOM   6736 O OD2 . ASP D 1 113 ? -97.553  65.068 76.068  1.00 71.49  ? 963  ASP D OD2 1 
ATOM   6737 N N   . PRO D 1 114 ? -94.685  62.645 78.904  1.00 45.62  ? 964  PRO D N   1 
ATOM   6738 C CA  . PRO D 1 114 ? -95.187  61.305 79.042  1.00 43.34  ? 964  PRO D CA  1 
ATOM   6739 C C   . PRO D 1 114 ? -96.647  61.346 79.534  1.00 47.14  ? 964  PRO D C   1 
ATOM   6740 O O   . PRO D 1 114 ? -96.962  62.215 80.296  1.00 48.40  ? 964  PRO D O   1 
ATOM   6741 C CB  . PRO D 1 114 ? -94.227  60.714 80.068  1.00 40.09  ? 964  PRO D CB  1 
ATOM   6742 C CG  . PRO D 1 114 ? -92.993  61.559 80.006  1.00 47.22  ? 964  PRO D CG  1 
ATOM   6743 C CD  . PRO D 1 114 ? -93.495  62.942 79.687  1.00 48.00  ? 964  PRO D CD  1 
ATOM   6744 N N   . ASP D 1 115 ? -97.491  60.437 79.051  1.00 45.93  ? 965  ASP D N   1 
ATOM   6745 C CA  . ASP D 1 115 ? -98.915  60.347 79.455  1.00 43.30  ? 965  ASP D CA  1 
ATOM   6746 C C   . ASP D 1 115 ? -99.181  59.079 80.260  1.00 39.75  ? 965  ASP D C   1 
ATOM   6747 O O   . ASP D 1 115 ? -99.203  58.002 79.687  1.00 41.05  ? 965  ASP D O   1 
ATOM   6748 C CB  . ASP D 1 115 ? -99.826  60.280 78.242  1.00 49.49  ? 965  ASP D CB  1 
ATOM   6749 C CG  . ASP D 1 115 ? -101.304 60.349 78.575  1.00 54.99  ? 965  ASP D CG  1 
ATOM   6750 O OD1 . ASP D 1 115 ? -101.632 60.575 79.748  1.00 50.22  ? 965  ASP D OD1 1 
ATOM   6751 O OD2 . ASP D 1 115 ? -102.108 60.203 77.644  1.00 59.77  ? 965  ASP D OD2 1 
ATOM   6752 N N   . PRO D 1 116 ? -99.416  59.195 81.576  1.00 42.20  ? 966  PRO D N   1 
ATOM   6753 C CA  . PRO D 1 116 ? -99.642  58.026 82.411  1.00 40.25  ? 966  PRO D CA  1 
ATOM   6754 C C   . PRO D 1 116 ? -100.820 57.136 81.980  1.00 40.79  ? 966  PRO D C   1 
ATOM   6755 O O   . PRO D 1 116 ? -100.823 55.994 82.288  1.00 40.75  ? 966  PRO D O   1 
ATOM   6756 C CB  . PRO D 1 116 ? -99.906  58.690 83.761  1.00 42.12  ? 966  PRO D CB  1 
ATOM   6757 C CG  . PRO D 1 116 ? -99.142  59.976 83.709  1.00 46.70  ? 966  PRO D CG  1 
ATOM   6758 C CD  . PRO D 1 116 ? -99.404  60.457 82.304  1.00 47.62  ? 966  PRO D CD  1 
ATOM   6759 N N   . ARG D 1 117 ? -101.765 57.699 81.243  1.00 39.87  ? 967  ARG D N   1 
ATOM   6760 C CA  . ARG D 1 117 ? -102.978 56.959 80.810  1.00 41.64  ? 967  ARG D CA  1 
ATOM   6761 C C   . ARG D 1 117 ? -102.631 55.768 79.908  1.00 43.66  ? 967  ARG D C   1 
ATOM   6762 O O   . ARG D 1 117 ? -103.425 54.841 79.837  1.00 43.26  ? 967  ARG D O   1 
ATOM   6763 C CB  . ARG D 1 117 ? -103.942 57.966 80.178  1.00 45.49  ? 967  ARG D CB  1 
ATOM   6764 C CG  . ARG D 1 117 ? -104.469 59.017 81.144  1.00 49.76  ? 967  ARG D CG  1 
ATOM   6765 C CD  . ARG D 1 117 ? -105.283 60.100 80.463  1.00 52.88  ? 967  ARG D CD  1 
ATOM   6766 N NE  . ARG D 1 117 ? -104.475 60.871 79.533  1.00 52.67  ? 967  ARG D NE  1 
ATOM   6767 C CZ  . ARG D 1 117 ? -104.913 61.892 78.811  1.00 57.38  ? 967  ARG D CZ  1 
ATOM   6768 N NH1 . ARG D 1 117 ? -106.166 62.290 78.921  1.00 62.24  ? 967  ARG D NH1 1 
ATOM   6769 N NH2 . ARG D 1 117 ? -104.098 62.512 77.977  1.00 57.58  ? 967  ARG D NH2 1 
ATOM   6770 N N   . LEU D 1 118 ? -101.464 55.787 79.269  1.00 42.52  ? 968  LEU D N   1 
ATOM   6771 C CA  . LEU D 1 118 ? -101.095 54.673 78.365  1.00 39.22  ? 968  LEU D CA  1 
ATOM   6772 C C   . LEU D 1 118 ? -100.949 53.389 79.168  1.00 44.96  ? 968  LEU D C   1 
ATOM   6773 O O   . LEU D 1 118 ? -101.159 52.328 78.592  1.00 41.63  ? 968  LEU D O   1 
ATOM   6774 C CB  . LEU D 1 118 ? -99.794  55.009 77.632  1.00 39.38  ? 968  LEU D CB  1 
ATOM   6775 C CG  . LEU D 1 118 ? -99.189  53.876 76.811  1.00 44.51  ? 968  LEU D CG  1 
ATOM   6776 C CD1 . LEU D 1 118 ? -100.110 53.497 75.667  1.00 46.50  ? 968  LEU D CD1 1 
ATOM   6777 C CD2 . LEU D 1 118 ? -97.820  54.271 76.284  1.00 43.64  ? 968  LEU D CD2 1 
ATOM   6778 N N   . PHE D 1 119 ? -100.659 53.502 80.458  1.00 38.95  ? 969  PHE D N   1 
ATOM   6779 C CA  . PHE D 1 119 ? -100.375 52.302 81.281  1.00 42.10  ? 969  PHE D CA  1 
ATOM   6780 C C   . PHE D 1 119 ? -101.641 51.820 82.003  1.00 49.42  ? 969  PHE D C   1 
ATOM   6781 O O   . PHE D 1 119 ? -101.582 50.805 82.695  1.00 52.20  ? 969  PHE D O   1 
ATOM   6782 C CB  . PHE D 1 119 ? -99.228  52.654 82.226  1.00 39.22  ? 969  PHE D CB  1 
ATOM   6783 C CG  . PHE D 1 119 ? -97.989  53.132 81.514  1.00 33.95  ? 969  PHE D CG  1 
ATOM   6784 C CD1 . PHE D 1 119 ? -97.181  52.242 80.832  1.00 39.69  ? 969  PHE D CD1 1 
ATOM   6785 C CD2 . PHE D 1 119 ? -97.667  54.476 81.475  1.00 40.62  ? 969  PHE D CD2 1 
ATOM   6786 C CE1 . PHE D 1 119 ? -96.052  52.679 80.162  1.00 38.11  ? 969  PHE D CE1 1 
ATOM   6787 C CE2 . PHE D 1 119 ? -96.540  54.913 80.801  1.00 43.32  ? 969  PHE D CE2 1 
ATOM   6788 C CZ  . PHE D 1 119 ? -95.735  54.012 80.147  1.00 33.64  ? 969  PHE D CZ  1 
ATOM   6789 N N   . ASP D 1 120 ? -102.746 52.534 81.829  1.00 50.51  ? 970  ASP D N   1 
ATOM   6790 C CA  . ASP D 1 120 ? -104.031 52.167 82.479  1.00 56.44  ? 970  ASP D CA  1 
ATOM   6791 C C   . ASP D 1 120 ? -104.747 51.196 81.544  1.00 58.69  ? 970  ASP D C   1 
ATOM   6792 O O   . ASP D 1 120 ? -105.446 50.314 82.036  1.00 68.60  ? 970  ASP D O   1 
ATOM   6793 C CB  . ASP D 1 120 ? -104.813 53.443 82.764  1.00 54.09  ? 970  ASP D CB  1 
ATOM   6794 C CG  . ASP D 1 120 ? -104.175 54.304 83.833  1.00 53.26  ? 970  ASP D CG  1 
ATOM   6795 O OD1 . ASP D 1 120 ? -103.246 53.813 84.488  1.00 58.13  ? 970  ASP D OD1 1 
ATOM   6796 O OD2 . ASP D 1 120 ? -104.592 55.461 83.972  1.00 57.27  ? 970  ASP D OD2 1 
ATOM   6797 N N   . HIS D 1 121 ? -104.538 51.354 80.246  1.00 62.08  ? 971  HIS D N   1 
ATOM   6798 C CA  . HIS D 1 121 ? -105.109 50.437 79.227  1.00 71.12  ? 971  HIS D CA  1 
ATOM   6799 C C   . HIS D 1 121 ? -103.976 49.764 78.441  1.00 68.71  ? 971  HIS D C   1 
ATOM   6800 O O   . HIS D 1 121 ? -103.018 50.460 78.059  1.00 66.15  ? 971  HIS D O   1 
ATOM   6801 C CB  . HIS D 1 121 ? -105.984 51.202 78.234  1.00 71.15  ? 971  HIS D CB  1 
ATOM   6802 C CG  . HIS D 1 121 ? -106.898 52.196 78.855  1.00 75.50  ? 971  HIS D CG  1 
ATOM   6803 N ND1 . HIS D 1 121 ? -106.448 53.382 79.391  1.00 68.77  ? 971  HIS D ND1 1 
ATOM   6804 C CD2 . HIS D 1 121 ? -108.227 52.209 78.980  1.00 75.76  ? 971  HIS D CD2 1 
ATOM   6805 C CE1 . HIS D 1 121 ? -107.484 54.070 79.845  1.00 78.30  ? 971  HIS D CE1 1 
ATOM   6806 N NE2 . HIS D 1 121 ? -108.573 53.373 79.611  1.00 76.14  ? 971  HIS D NE2 1 
ATOM   6807 N N   . PHE D 1 134 ? -105.694 30.434 89.584  1.00 74.60  ? 984  PHE D N   1 
ATOM   6808 C CA  . PHE D 1 134 ? -104.495 31.275 89.340  1.00 72.47  ? 984  PHE D CA  1 
ATOM   6809 C C   . PHE D 1 134 ? -103.246 30.422 89.507  1.00 71.37  ? 984  PHE D C   1 
ATOM   6810 O O   . PHE D 1 134 ? -103.331 29.362 90.138  1.00 73.68  ? 984  PHE D O   1 
ATOM   6811 C CB  . PHE D 1 134 ? -104.442 32.459 90.296  1.00 73.82  ? 984  PHE D CB  1 
ATOM   6812 C CG  . PHE D 1 134 ? -104.127 33.754 89.599  1.00 76.87  ? 984  PHE D CG  1 
ATOM   6813 C CD1 . PHE D 1 134 ? -105.094 34.401 88.846  1.00 73.91  ? 984  PHE D CD1 1 
ATOM   6814 C CD2 . PHE D 1 134 ? -102.850 34.289 89.644  1.00 72.79  ? 984  PHE D CD2 1 
ATOM   6815 C CE1 . PHE D 1 134 ? -104.805 35.582 88.183  1.00 71.92  ? 984  PHE D CE1 1 
ATOM   6816 C CE2 . PHE D 1 134 ? -102.561 35.458 88.956  1.00 71.14  ? 984  PHE D CE2 1 
ATOM   6817 C CZ  . PHE D 1 134 ? -103.540 36.112 88.245  1.00 68.62  ? 984  PHE D CZ  1 
ATOM   6818 N N   . LEU D 1 135 ? -102.126 30.860 88.946  1.00 66.90  ? 985  LEU D N   1 
ATOM   6819 C CA  . LEU D 1 135 ? -100.963 29.946 89.019  1.00 63.47  ? 985  LEU D CA  1 
ATOM   6820 C C   . LEU D 1 135 ? -99.952  30.592 89.951  1.00 63.10  ? 985  LEU D C   1 
ATOM   6821 O O   . LEU D 1 135 ? -99.662  31.782 89.821  1.00 57.35  ? 985  LEU D O   1 
ATOM   6822 C CB  . LEU D 1 135 ? -100.345 29.681 87.644  1.00 63.53  ? 985  LEU D CB  1 
ATOM   6823 C CG  . LEU D 1 135 ? -101.095 28.701 86.746  1.00 68.25  ? 985  LEU D CG  1 
ATOM   6824 C CD1 . LEU D 1 135 ? -100.340 28.505 85.445  1.00 63.16  ? 985  LEU D CD1 1 
ATOM   6825 C CD2 . LEU D 1 135 ? -101.229 27.362 87.467  1.00 67.88  ? 985  LEU D CD2 1 
ATOM   6826 N N   . ALA D 1 136 ? -99.365  29.771 90.808  1.00 59.97  ? 986  ALA D N   1 
ATOM   6827 C CA  . ALA D 1 136 ? -98.327  30.269 91.720  1.00 59.30  ? 986  ALA D CA  1 
ATOM   6828 C C   . ALA D 1 136 ? -96.968  30.260 91.021  1.00 52.33  ? 986  ALA D C   1 
ATOM   6829 O O   . ALA D 1 136 ? -96.838  29.586 90.017  1.00 55.90  ? 986  ALA D O   1 
ATOM   6830 C CB  . ALA D 1 136 ? -98.313  29.432 92.954  1.00 57.12  ? 986  ALA D CB  1 
ATOM   6831 N N   . GLN D 1 137 ? -95.999  30.970 91.579  1.00 56.63  ? 987  GLN D N   1 
ATOM   6832 C CA  . GLN D 1 137 ? -94.654  31.119 90.967  1.00 54.37  ? 987  GLN D CA  1 
ATOM   6833 C C   . GLN D 1 137 ? -94.064  29.787 90.537  1.00 56.06  ? 987  GLN D C   1 
ATOM   6834 O O   . GLN D 1 137 ? -93.682  29.658 89.381  1.00 55.19  ? 987  GLN D O   1 
ATOM   6835 C CB  . GLN D 1 137 ? -93.729  31.790 91.978  1.00 55.13  ? 987  GLN D CB  1 
ATOM   6836 C CG  . GLN D 1 137 ? -92.318  32.068 91.488  1.00 53.45  ? 987  GLN D CG  1 
ATOM   6837 C CD  . GLN D 1 137 ? -91.605  32.976 92.457  1.00 57.56  ? 987  GLN D CD  1 
ATOM   6838 O OE1 . GLN D 1 137 ? -91.127  34.047 92.103  1.00 58.64  ? 987  GLN D OE1 1 
ATOM   6839 N NE2 . GLN D 1 137 ? -91.542  32.562 93.709  1.00 60.92  ? 987  GLN D NE2 1 
ATOM   6840 N N   . ALA D 1 138 ? -94.012  28.834 91.451  1.00 56.98  ? 988  ALA D N   1 
ATOM   6841 C CA  . ALA D 1 138 ? -93.390  27.537 91.130  1.00 55.53  ? 988  ALA D CA  1 
ATOM   6842 C C   . ALA D 1 138 ? -94.138  26.843 90.000  1.00 56.13  ? 988  ALA D C   1 
ATOM   6843 O O   . ALA D 1 138 ? -93.485  26.223 89.166  1.00 61.88  ? 988  ALA D O   1 
ATOM   6844 C CB  . ALA D 1 138 ? -93.358  26.688 92.359  1.00 62.85  ? 988  ALA D CB  1 
ATOM   6845 N N   . GLU D 1 139 ? -95.454  26.968 89.983  1.00 54.35  ? 989  GLU D N   1 
ATOM   6846 C CA  . GLU D 1 139 ? -96.254  26.365 88.895  1.00 59.43  ? 989  GLU D CA  1 
ATOM   6847 C C   . GLU D 1 139 ? -95.935  27.075 87.577  1.00 58.92  ? 989  GLU D C   1 
ATOM   6848 O O   . GLU D 1 139 ? -95.845  26.416 86.548  1.00 59.57  ? 989  GLU D O   1 
ATOM   6849 C CB  . GLU D 1 139 ? -97.742  26.488 89.232  1.00 61.71  ? 989  GLU D CB  1 
ATOM   6850 C CG  . GLU D 1 139 ? -98.085  26.077 90.655  1.00 68.38  ? 989  GLU D CG  1 
ATOM   6851 C CD  . GLU D 1 139 ? -99.540  26.274 91.048  1.00 71.09  ? 989  GLU D CD  1 
ATOM   6852 O OE1 . GLU D 1 139 ? -100.411 25.633 90.439  1.00 73.88  ? 989  GLU D OE1 1 
ATOM   6853 O OE2 . GLU D 1 139 ? -99.799  27.080 91.954  1.00 72.08  ? 989  GLU D OE2 1 
ATOM   6854 N N   . VAL D 1 140 ? -95.799  28.390 87.628  1.00 58.31  ? 990  VAL D N   1 
ATOM   6855 C CA  . VAL D 1 140 ? -95.502  29.179 86.399  1.00 57.36  ? 990  VAL D CA  1 
ATOM   6856 C C   . VAL D 1 140 ? -94.173  28.715 85.813  1.00 52.06  ? 990  VAL D C   1 
ATOM   6857 O O   . VAL D 1 140 ? -94.128  28.444 84.624  1.00 53.18  ? 990  VAL D O   1 
ATOM   6858 C CB  . VAL D 1 140 ? -95.478  30.684 86.703  1.00 52.79  ? 990  VAL D CB  1 
ATOM   6859 C CG1 . VAL D 1 140 ? -94.946  31.482 85.526  1.00 52.33  ? 990  VAL D CG1 1 
ATOM   6860 C CG2 . VAL D 1 140 ? -96.838  31.204 87.129  1.00 52.89  ? 990  VAL D CG2 1 
ATOM   6861 N N   . TYR D 1 141 ? -93.167  28.543 86.653  1.00 54.61  ? 991  TYR D N   1 
ATOM   6862 C CA  . TYR D 1 141 ? -91.813  28.260 86.118  1.00 55.25  ? 991  TYR D CA  1 
ATOM   6863 C C   . TYR D 1 141 ? -91.663  26.780 85.774  1.00 58.44  ? 991  TYR D C   1 
ATOM   6864 O O   . TYR D 1 141 ? -90.775  26.455 84.995  1.00 61.33  ? 991  TYR D O   1 
ATOM   6865 C CB  . TYR D 1 141 ? -90.789  28.912 87.050  1.00 52.65  ? 991  TYR D CB  1 
ATOM   6866 C CG  . TYR D 1 141 ? -90.793  30.409 86.897  1.00 48.26  ? 991  TYR D CG  1 
ATOM   6867 C CD1 . TYR D 1 141 ? -90.313  30.998 85.743  1.00 44.41  ? 991  TYR D CD1 1 
ATOM   6868 C CD2 . TYR D 1 141 ? -91.371  31.225 87.851  1.00 49.26  ? 991  TYR D CD2 1 
ATOM   6869 C CE1 . TYR D 1 141 ? -90.349  32.367 85.565  1.00 40.33  ? 991  TYR D CE1 1 
ATOM   6870 C CE2 . TYR D 1 141 ? -91.420  32.597 87.687  1.00 45.21  ? 991  TYR D CE2 1 
ATOM   6871 C CZ  . TYR D 1 141 ? -90.907  33.170 86.539  1.00 40.93  ? 991  TYR D CZ  1 
ATOM   6872 O OH  . TYR D 1 141 ? -90.946  34.524 86.366  1.00 42.32  ? 991  TYR D OH  1 
ATOM   6873 N N   . LYS D 1 142 ? -92.533  25.933 86.313  1.00 59.97  ? 992  LYS D N   1 
ATOM   6874 C CA  . LYS D 1 142 ? -92.522  24.508 85.920  1.00 59.58  ? 992  LYS D CA  1 
ATOM   6875 C C   . LYS D 1 142 ? -93.124  24.434 84.520  1.00 59.56  ? 992  LYS D C   1 
ATOM   6876 O O   . LYS D 1 142 ? -92.597  23.703 83.688  1.00 65.56  ? 992  LYS D O   1 
ATOM   6877 C CB  . LYS D 1 142 ? -93.332  23.689 86.931  1.00 64.19  ? 992  LYS D CB  1 
ATOM   6878 C CG  . LYS D 1 142 ? -93.524  22.221 86.578  1.00 70.61  ? 992  LYS D CG  1 
ATOM   6879 C CD  . LYS D 1 142 ? -92.657  21.283 87.392  1.00 76.29  ? 992  LYS D CD  1 
ATOM   6880 C CE  . LYS D 1 142 ? -92.679  19.862 86.869  1.00 84.22  ? 992  LYS D CE  1 
ATOM   6881 N NZ  . LYS D 1 142 ? -91.723  18.989 87.591  1.00 85.66  ? 992  LYS D NZ  1 
ATOM   6882 N N   . GLU D 1 143 ? -94.174  25.207 84.285  1.00 56.04  ? 993  GLU D N   1 
ATOM   6883 C CA  . GLU D 1 143 ? -94.832  25.219 82.958  1.00 60.22  ? 993  GLU D CA  1 
ATOM   6884 C C   . GLU D 1 143 ? -93.872  25.760 81.896  1.00 63.68  ? 993  GLU D C   1 
ATOM   6885 O O   . GLU D 1 143 ? -93.669  25.089 80.889  1.00 64.88  ? 993  GLU D O   1 
ATOM   6886 C CB  . GLU D 1 143 ? -96.105  26.050 83.017  1.00 61.75  ? 993  GLU D CB  1 
ATOM   6887 C CG  . GLU D 1 143 ? -96.764  26.254 81.669  1.00 68.14  ? 993  GLU D CG  1 
ATOM   6888 C CD  . GLU D 1 143 ? -97.310  25.004 81.006  1.00 75.07  ? 993  GLU D CD  1 
ATOM   6889 O OE1 . GLU D 1 143 ? -97.231  23.919 81.617  1.00 77.38  ? 993  GLU D OE1 1 
ATOM   6890 O OE2 . GLU D 1 143 ? -97.804  25.119 79.874  1.00 77.85  ? 993  GLU D OE2 1 
ATOM   6891 N N   . LEU D 1 144 ? -93.286  26.924 82.144  1.00 61.13  ? 994  LEU D N   1 
ATOM   6892 C CA  . LEU D 1 144 ? -92.353  27.541 81.167  1.00 58.02  ? 994  LEU D CA  1 
ATOM   6893 C C   . LEU D 1 144 ? -91.204  26.560 80.926  1.00 59.74  ? 994  LEU D C   1 
ATOM   6894 O O   . LEU D 1 144 ? -90.822  26.374 79.773  1.00 60.75  ? 994  LEU D O   1 
ATOM   6895 C CB  . LEU D 1 144 ? -91.874  28.874 81.751  1.00 54.00  ? 994  LEU D CB  1 
ATOM   6896 C CG  . LEU D 1 144 ? -92.904  29.993 81.851  1.00 48.96  ? 994  LEU D CG  1 
ATOM   6897 C CD1 . LEU D 1 144 ? -92.318  31.184 82.587  1.00 49.42  ? 994  LEU D CD1 1 
ATOM   6898 C CD2 . LEU D 1 144 ? -93.378  30.411 80.473  1.00 54.08  ? 994  LEU D CD2 1 
ATOM   6899 N N   . ARG D 1 145 ? -90.726  25.917 81.977  1.00 56.88  ? 995  ARG D N   1 
ATOM   6900 C CA  . ARG D 1 145 ? -89.583  24.982 81.861  1.00 62.44  ? 995  ARG D CA  1 
ATOM   6901 C C   . ARG D 1 145 ? -89.975  23.787 81.001  1.00 63.68  ? 995  ARG D C   1 
ATOM   6902 O O   . ARG D 1 145 ? -89.120  23.259 80.298  1.00 63.90  ? 995  ARG D O   1 
ATOM   6903 C CB  . ARG D 1 145 ? -89.188  24.490 83.254  1.00 63.73  ? 995  ARG D CB  1 
ATOM   6904 C CG  . ARG D 1 145 ? -87.765  23.976 83.386  1.00 64.00  ? 995  ARG D CG  1 
ATOM   6905 C CD  . ARG D 1 145 ? -87.258  24.255 84.791  1.00 68.88  ? 995  ARG D CD  1 
ATOM   6906 N NE  . ARG D 1 145 ? -88.217  23.918 85.833  1.00 75.07  ? 995  ARG D NE  1 
ATOM   6907 C CZ  . ARG D 1 145 ? -88.630  24.739 86.793  1.00 74.37  ? 995  ARG D CZ  1 
ATOM   6908 N NH1 . ARG D 1 145 ? -87.996  25.875 87.018  1.00 71.26  ? 995  ARG D NH1 1 
ATOM   6909 N NH2 . ARG D 1 145 ? -89.663  24.406 87.547  1.00 68.94  ? 995  ARG D NH2 1 
ATOM   6910 N N   . LEU D 1 146 ? -91.225  23.365 81.120  1.00 64.88  ? 996  LEU D N   1 
ATOM   6911 C CA  . LEU D 1 146 ? -91.707  22.218 80.319  1.00 67.37  ? 996  LEU D CA  1 
ATOM   6912 C C   . LEU D 1 146 ? -91.824  22.663 78.865  1.00 66.77  ? 996  LEU D C   1 
ATOM   6913 O O   . LEU D 1 146 ? -91.554  21.845 77.982  1.00 69.38  ? 996  LEU D O   1 
ATOM   6914 C CB  . LEU D 1 146 ? -93.054  21.756 80.875  1.00 67.13  ? 996  LEU D CB  1 
ATOM   6915 C CG  . LEU D 1 146 ? -92.986  20.680 81.954  1.00 70.73  ? 996  LEU D CG  1 
ATOM   6916 C CD1 . LEU D 1 146 ? -94.380  20.216 82.333  1.00 74.28  ? 996  LEU D CD1 1 
ATOM   6917 C CD2 . LEU D 1 146 ? -92.149  19.506 81.480  1.00 72.34  ? 996  LEU D CD2 1 
ATOM   6918 N N   . ARG D 1 147 ? -92.172  23.927 78.647  1.00 62.32  ? 997  ARG D N   1 
ATOM   6919 C CA  . ARG D 1 147 ? -92.311  24.447 77.268  1.00 64.90  ? 997  ARG D CA  1 
ATOM   6920 C C   . ARG D 1 147 ? -90.920  24.722 76.695  1.00 60.77  ? 997  ARG D C   1 
ATOM   6921 O O   . ARG D 1 147 ? -90.829  24.985 75.502  1.00 64.39  ? 997  ARG D O   1 
ATOM   6922 C CB  . ARG D 1 147 ? -93.248  25.656 77.264  1.00 63.70  ? 997  ARG D CB  1 
ATOM   6923 C CG  . ARG D 1 147 ? -94.611  25.368 77.870  1.00 67.97  ? 997  ARG D CG  1 
ATOM   6924 C CD  . ARG D 1 147 ? -95.350  26.646 78.188  1.00 68.34  ? 997  ARG D CD  1 
ATOM   6925 N NE  . ARG D 1 147 ? -96.706  26.593 77.677  1.00 76.28  ? 997  ARG D NE  1 
ATOM   6926 C CZ  . ARG D 1 147 ? -97.162  27.381 76.716  1.00 81.42  ? 997  ARG D CZ  1 
ATOM   6927 N NH1 . ARG D 1 147 ? -96.366  28.288 76.180  1.00 77.82  ? 997  ARG D NH1 1 
ATOM   6928 N NH2 . ARG D 1 147 ? -98.404  27.249 76.284  1.00 83.55  ? 997  ARG D NH2 1 
ATOM   6929 N N   . GLY D 1 148 ? -89.891  24.656 77.525  1.00 58.75  ? 998  GLY D N   1 
ATOM   6930 C CA  . GLY D 1 148 ? -88.529  24.807 77.041  1.00 60.29  ? 998  GLY D CA  1 
ATOM   6931 C C   . GLY D 1 148 ? -87.780  26.035 77.512  1.00 60.99  ? 998  GLY D C   1 
ATOM   6932 O O   . GLY D 1 148 ? -86.669  26.287 77.025  1.00 62.30  ? 998  GLY D O   1 
ATOM   6933 N N   . TYR D 1 149 ? -88.364  26.823 78.404  1.00 56.41  ? 999  TYR D N   1 
ATOM   6934 C CA  . TYR D 1 149 ? -87.796  28.080 78.877  1.00 56.37  ? 999  TYR D CA  1 
ATOM   6935 C C   . TYR D 1 149 ? -87.303  27.957 80.318  1.00 56.82  ? 999  TYR D C   1 
ATOM   6936 O O   . TYR D 1 149 ? -88.107  27.778 81.239  1.00 55.22  ? 999  TYR D O   1 
ATOM   6937 C CB  . TYR D 1 149 ? -88.812  29.209 78.737  1.00 51.83  ? 999  TYR D CB  1 
ATOM   6938 C CG  . TYR D 1 149 ? -89.415  29.330 77.350  1.00 54.06  ? 999  TYR D CG  1 
ATOM   6939 C CD1 . TYR D 1 149 ? -90.195  28.314 76.802  1.00 57.83  ? 999  TYR D CD1 1 
ATOM   6940 C CD2 . TYR D 1 149 ? -89.136  30.425 76.558  1.00 56.05  ? 999  TYR D CD2 1 
ATOM   6941 C CE1 . TYR D 1 149 ? -90.728  28.423 75.535  1.00 61.28  ? 999  TYR D CE1 1 
ATOM   6942 C CE2 . TYR D 1 149 ? -89.648  30.527 75.282  1.00 60.15  ? 999  TYR D CE2 1 
ATOM   6943 C CZ  . TYR D 1 149 ? -90.454  29.539 74.781  1.00 63.31  ? 999  TYR D CZ  1 
ATOM   6944 O OH  . TYR D 1 149 ? -90.967  29.668 73.512  1.00 66.59  ? 999  TYR D OH  1 
ATOM   6945 N N   . ASP D 1 150 ? -85.988  28.061 80.512  1.00 56.41  ? 1000 ASP D N   1 
ATOM   6946 C CA  . ASP D 1 150 ? -85.350  27.896 81.818  1.00 57.40  ? 1000 ASP D CA  1 
ATOM   6947 C C   . ASP D 1 150 ? -84.971  29.254 82.400  1.00 51.17  ? 1000 ASP D C   1 
ATOM   6948 O O   . ASP D 1 150 ? -84.203  30.005 81.790  1.00 54.03  ? 1000 ASP D O   1 
ATOM   6949 C CB  . ASP D 1 150 ? -84.114  27.007 81.729  1.00 56.26  ? 1000 ASP D CB  1 
ATOM   6950 C CG  . ASP D 1 150 ? -84.265  25.908 80.718  1.00 60.90  ? 1000 ASP D CG  1 
ATOM   6951 O OD1 . ASP D 1 150 ? -85.203  25.098 80.864  1.00 63.79  ? 1000 ASP D OD1 1 
ATOM   6952 O OD2 . ASP D 1 150 ? -83.435  25.840 79.788  1.00 58.75  ? 1000 ASP D OD2 1 
ATOM   6953 N N   . TYR D 1 151 ? -85.618  29.625 83.503  1.00 49.04  ? 1001 TYR D N   1 
ATOM   6954 C CA  . TYR D 1 151 ? -85.311  30.856 84.222  1.00 42.79  ? 1001 TYR D CA  1 
ATOM   6955 C C   . TYR D 1 151 ? -84.829  30.515 85.628  1.00 48.14  ? 1001 TYR D C   1 
ATOM   6956 O O   . TYR D 1 151 ? -85.541  29.841 86.381  1.00 50.89  ? 1001 TYR D O   1 
ATOM   6957 C CB  . TYR D 1 151 ? -86.540  31.754 84.268  1.00 45.17  ? 1001 TYR D CB  1 
ATOM   6958 C CG  . TYR D 1 151 ? -87.017  32.157 82.892  1.00 49.14  ? 1001 TYR D CG  1 
ATOM   6959 C CD1 . TYR D 1 151 ? -86.351  33.122 82.146  1.00 41.54  ? 1001 TYR D CD1 1 
ATOM   6960 C CD2 . TYR D 1 151 ? -88.126  31.544 82.330  1.00 45.30  ? 1001 TYR D CD2 1 
ATOM   6961 C CE1 . TYR D 1 151 ? -86.798  33.477 80.883  1.00 42.93  ? 1001 TYR D CE1 1 
ATOM   6962 C CE2 . TYR D 1 151 ? -88.577  31.889 81.077  1.00 44.06  ? 1001 TYR D CE2 1 
ATOM   6963 C CZ  . TYR D 1 151 ? -87.913  32.854 80.355  1.00 47.30  ? 1001 TYR D CZ  1 
ATOM   6964 O OH  . TYR D 1 151 ? -88.373  33.191 79.103  1.00 42.51  ? 1001 TYR D OH  1 
ATOM   6965 N N   . GLY D 1 152 ? -83.641  30.998 85.992  1.00 45.98  ? 1002 GLY D N   1 
ATOM   6966 C CA  . GLY D 1 152 ? -83.186  30.905 87.359  1.00 41.60  ? 1002 GLY D CA  1 
ATOM   6967 C C   . GLY D 1 152 ? -83.779  31.998 88.222  1.00 42.12  ? 1002 GLY D C   1 
ATOM   6968 O O   . GLY D 1 152 ? -84.531  32.867 87.760  1.00 43.83  ? 1002 GLY D O   1 
ATOM   6969 N N   . PRO D 1 153 ? -83.418  31.976 89.511  1.00 42.47  ? 1003 PRO D N   1 
ATOM   6970 C CA  . PRO D 1 153 ? -84.091  32.854 90.488  1.00 38.85  ? 1003 PRO D CA  1 
ATOM   6971 C C   . PRO D 1 153 ? -84.155  34.324 90.101  1.00 43.05  ? 1003 PRO D C   1 
ATOM   6972 O O   . PRO D 1 153 ? -85.188  34.964 90.332  1.00 38.03  ? 1003 PRO D O   1 
ATOM   6973 C CB  . PRO D 1 153 ? -83.256  32.660 91.761  1.00 43.36  ? 1003 PRO D CB  1 
ATOM   6974 C CG  . PRO D 1 153 ? -82.585  31.342 91.606  1.00 47.61  ? 1003 PRO D CG  1 
ATOM   6975 C CD  . PRO D 1 153 ? -82.558  30.967 90.153  1.00 45.20  ? 1003 PRO D CD  1 
ATOM   6976 N N   . HIS D 1 154 ? -83.093  34.882 89.516  1.00 42.17  ? 1004 HIS D N   1 
ATOM   6977 C CA  . HIS D 1 154 ? -83.105  36.310 89.220  1.00 40.39  ? 1004 HIS D CA  1 
ATOM   6978 C C   . HIS D 1 154 ? -84.117  36.672 88.144  1.00 35.92  ? 1004 HIS D C   1 
ATOM   6979 O O   . HIS D 1 154 ? -84.545  37.829 88.079  1.00 39.13  ? 1004 HIS D O   1 
ATOM   6980 C CB  . HIS D 1 154 ? -81.714  36.779 88.796  1.00 39.07  ? 1004 HIS D CB  1 
ATOM   6981 C CG  . HIS D 1 154 ? -80.775  36.980 89.943  1.00 41.02  ? 1004 HIS D CG  1 
ATOM   6982 N ND1 . HIS D 1 154 ? -79.724  36.127 90.200  1.00 42.90  ? 1004 HIS D ND1 1 
ATOM   6983 C CD2 . HIS D 1 154 ? -80.740  37.925 90.911  1.00 37.51  ? 1004 HIS D CD2 1 
ATOM   6984 C CE1 . HIS D 1 154 ? -79.074  36.545 91.271  1.00 41.08  ? 1004 HIS D CE1 1 
ATOM   6985 N NE2 . HIS D 1 154 ? -79.671  37.634 91.723  1.00 45.55  ? 1004 HIS D NE2 1 
ATOM   6986 N N   . PHE D 1 155 ? -84.538  35.708 87.329  1.00 37.95  ? 1005 PHE D N   1 
ATOM   6987 C CA  . PHE D 1 155 ? -85.531  35.953 86.296  1.00 35.44  ? 1005 PHE D CA  1 
ATOM   6988 C C   . PHE D 1 155 ? -86.872  35.307 86.614  1.00 41.22  ? 1005 PHE D C   1 
ATOM   6989 O O   . PHE D 1 155 ? -87.749  35.267 85.746  1.00 37.86  ? 1005 PHE D O   1 
ATOM   6990 C CB  . PHE D 1 155 ? -85.017  35.479 84.935  1.00 39.83  ? 1005 PHE D CB  1 
ATOM   6991 C CG  . PHE D 1 155 ? -84.072  36.446 84.280  1.00 36.77  ? 1005 PHE D CG  1 
ATOM   6992 C CD1 . PHE D 1 155 ? -82.740  36.499 84.657  1.00 39.24  ? 1005 PHE D CD1 1 
ATOM   6993 C CD2 . PHE D 1 155 ? -84.522  37.319 83.304  1.00 35.64  ? 1005 PHE D CD2 1 
ATOM   6994 C CE1 . PHE D 1 155 ? -81.871  37.395 84.061  1.00 38.41  ? 1005 PHE D CE1 1 
ATOM   6995 C CE2 . PHE D 1 155 ? -83.659  38.219 82.705  1.00 35.81  ? 1005 PHE D CE2 1 
ATOM   6996 C CZ  . PHE D 1 155 ? -82.331  38.256 83.084  1.00 35.45  ? 1005 PHE D CZ  1 
ATOM   6997 N N   . GLN D 1 156 ? -87.054  34.796 87.831  1.00 40.18  ? 1006 GLN D N   1 
ATOM   6998 C CA  . GLN D 1 156 ? -88.357  34.277 88.242  1.00 42.84  ? 1006 GLN D CA  1 
ATOM   6999 C C   . GLN D 1 156 ? -89.144  35.380 88.948  1.00 45.35  ? 1006 GLN D C   1 
ATOM   7000 O O   . GLN D 1 156 ? -89.433  35.331 90.146  1.00 48.91  ? 1006 GLN D O   1 
ATOM   7001 C CB  . GLN D 1 156 ? -88.206  33.043 89.121  1.00 43.32  ? 1006 GLN D CB  1 
ATOM   7002 C CG  . GLN D 1 156 ? -87.739  31.804 88.384  1.00 42.91  ? 1006 GLN D CG  1 
ATOM   7003 C CD  . GLN D 1 156 ? -87.417  30.667 89.329  1.00 49.93  ? 1006 GLN D CD  1 
ATOM   7004 O OE1 . GLN D 1 156 ? -87.846  30.667 90.483  1.00 48.51  ? 1006 GLN D OE1 1 
ATOM   7005 N NE2 . GLN D 1 156 ? -86.678  29.680 88.840  1.00 49.97  ? 1006 GLN D NE2 1 
ATOM   7006 N N   . GLY D 1 157 ? -89.517  36.381 88.155  1.00 38.83  ? 1007 GLY D N   1 
ATOM   7007 C CA  . GLY D 1 157 ? -90.250  37.520 88.661  1.00 38.34  ? 1007 GLY D CA  1 
ATOM   7008 C C   . GLY D 1 157 ? -91.764  37.430 88.560  1.00 32.06  ? 1007 GLY D C   1 
ATOM   7009 O O   . GLY D 1 157 ? -92.453  38.264 89.144  1.00 35.68  ? 1007 GLY D O   1 
ATOM   7010 N N   . ILE D 1 158 ? -92.251  36.404 87.878  1.00 38.07  ? 1008 ILE D N   1 
ATOM   7011 C CA  . ILE D 1 158 ? -93.721  36.189 87.841  1.00 39.38  ? 1008 ILE D CA  1 
ATOM   7012 C C   . ILE D 1 158 ? -94.112  35.562 89.179  1.00 43.79  ? 1008 ILE D C   1 
ATOM   7013 O O   . ILE D 1 158 ? -93.717  34.441 89.425  1.00 42.55  ? 1008 ILE D O   1 
ATOM   7014 C CB  . ILE D 1 158 ? -94.162  35.318 86.657  1.00 38.35  ? 1008 ILE D CB  1 
ATOM   7015 C CG1 . ILE D 1 158 ? -93.802  35.947 85.311  1.00 36.84  ? 1008 ILE D CG1 1 
ATOM   7016 C CG2 . ILE D 1 158 ? -95.651  35.036 86.755  1.00 41.85  ? 1008 ILE D CG2 1 
ATOM   7017 C CD1 . ILE D 1 158 ? -94.191  35.105 84.127  1.00 38.43  ? 1008 ILE D CD1 1 
ATOM   7018 N N   . LEU D 1 159 ? -94.813  36.321 90.007  1.00 42.97  ? 1009 LEU D N   1 
ATOM   7019 C CA  . LEU D 1 159 ? -95.237  35.824 91.337  1.00 45.63  ? 1009 LEU D CA  1 
ATOM   7020 C C   . LEU D 1 159 ? -96.521  35.026 91.171  1.00 50.25  ? 1009 LEU D C   1 
ATOM   7021 O O   . LEU D 1 159 ? -96.699  34.043 91.876  1.00 50.73  ? 1009 LEU D O   1 
ATOM   7022 C CB  . LEU D 1 159 ? -95.490  37.034 92.224  1.00 44.35  ? 1009 LEU D CB  1 
ATOM   7023 C CG  . LEU D 1 159 ? -95.113  36.889 93.693  1.00 60.74  ? 1009 LEU D CG  1 
ATOM   7024 C CD1 . LEU D 1 159 ? -96.129  37.598 94.570  1.00 59.55  ? 1009 LEU D CD1 1 
ATOM   7025 C CD2 . LEU D 1 159 ? -95.001  35.427 94.087  1.00 56.48  ? 1009 LEU D CD2 1 
ATOM   7026 N N   . GLU D 1 160 ? -97.362  35.470 90.259  1.00 43.13  ? 1010 GLU D N   1 
ATOM   7027 C CA  . GLU D 1 160 ? -98.670  34.824 90.067  1.00 54.19  ? 1010 GLU D CA  1 
ATOM   7028 C C   . GLU D 1 160 ? -99.185  35.141 88.667  1.00 56.41  ? 1010 GLU D C   1 
ATOM   7029 O O   . GLU D 1 160 ? -99.027  36.276 88.218  1.00 51.46  ? 1010 GLU D O   1 
ATOM   7030 C CB  . GLU D 1 160 ? -99.610  35.388 91.125  1.00 52.53  ? 1010 GLU D CB  1 
ATOM   7031 C CG  . GLU D 1 160 ? -101.042 34.944 90.988  1.00 67.26  ? 1010 GLU D CG  1 
ATOM   7032 C CD  . GLU D 1 160 ? -101.958 35.786 91.854  1.00 72.29  ? 1010 GLU D CD  1 
ATOM   7033 O OE1 . GLU D 1 160 ? -101.730 35.831 93.075  1.00 64.36  ? 1010 GLU D OE1 1 
ATOM   7034 O OE2 . GLU D 1 160 ? -102.867 36.417 91.296  1.00 77.13  ? 1010 GLU D OE2 1 
ATOM   7035 N N   . ALA D 1 161 ? -99.807  34.161 88.026  1.00 56.36  ? 1011 ALA D N   1 
ATOM   7036 C CA  . ALA D 1 161 ? -100.412 34.410 86.708  1.00 55.47  ? 1011 ALA D CA  1 
ATOM   7037 C C   . ALA D 1 161 ? -101.686 33.590 86.496  1.00 61.87  ? 1011 ALA D C   1 
ATOM   7038 O O   . ALA D 1 161 ? -101.788 32.506 87.053  1.00 61.69  ? 1011 ALA D O   1 
ATOM   7039 C CB  . ALA D 1 161 ? -99.404  34.096 85.651  1.00 53.27  ? 1011 ALA D CB  1 
ATOM   7040 N N   . SER D 1 162 ? -102.596 34.111 85.687  1.00 61.83  ? 1012 SER D N   1 
ATOM   7041 C CA  . SER D 1 162 ? -103.844 33.404 85.326  1.00 63.46  ? 1012 SER D CA  1 
ATOM   7042 C C   . SER D 1 162 ? -103.495 32.193 84.485  1.00 70.21  ? 1012 SER D C   1 
ATOM   7043 O O   . SER D 1 162 ? -102.384 32.130 83.962  1.00 70.17  ? 1012 SER D O   1 
ATOM   7044 C CB  . SER D 1 162 ? -104.718 34.310 84.539  1.00 65.08  ? 1012 SER D CB  1 
ATOM   7045 O OG  . SER D 1 162 ? -104.114 34.643 83.303  1.00 59.84  ? 1012 SER D OG  1 
ATOM   7046 N N   . LEU D 1 163 ? -104.430 31.262 84.377  1.00 74.82  ? 1013 LEU D N   1 
ATOM   7047 C CA  . LEU D 1 163 ? -104.139 30.032 83.617  1.00 74.83  ? 1013 LEU D CA  1 
ATOM   7048 C C   . LEU D 1 163 ? -103.781 30.475 82.207  1.00 79.59  ? 1013 LEU D C   1 
ATOM   7049 O O   . LEU D 1 163 ? -102.718 30.086 81.708  1.00 79.08  ? 1013 LEU D O   1 
ATOM   7050 C CB  . LEU D 1 163 ? -105.373 29.130 83.619  1.00 80.35  ? 1013 LEU D CB  1 
ATOM   7051 C CG  . LEU D 1 163 ? -105.968 28.827 84.993  1.00 80.74  ? 1013 LEU D CG  1 
ATOM   7052 C CD1 . LEU D 1 163 ? -107.112 27.834 84.876  1.00 84.77  ? 1013 LEU D CD1 1 
ATOM   7053 C CD2 . LEU D 1 163 ? -104.905 28.297 85.943  1.00 79.49  ? 1013 LEU D CD2 1 
ATOM   7054 N N   . GLU D 1 164 ? -104.632 31.309 81.627  1.00 78.74  ? 1014 GLU D N   1 
ATOM   7055 C CA  . GLU D 1 164 ? -104.458 31.613 80.187  1.00 79.94  ? 1014 GLU D CA  1 
ATOM   7056 C C   . GLU D 1 164 ? -103.233 32.508 79.978  1.00 77.75  ? 1014 GLU D C   1 
ATOM   7057 O O   . GLU D 1 164 ? -102.835 32.675 78.827  1.00 78.77  ? 1014 GLU D O   1 
ATOM   7058 C CB  . GLU D 1 164 ? -105.727 32.239 79.620  1.00 77.74  ? 1014 GLU D CB  1 
ATOM   7059 C CG  . GLU D 1 164 ? -106.638 31.206 78.987  1.00 89.44  ? 1014 GLU D CG  1 
ATOM   7060 C CD  . GLU D 1 164 ? -105.912 29.997 78.415  1.00 96.00  ? 1014 GLU D CD  1 
ATOM   7061 O OE1 . GLU D 1 164 ? -104.982 30.190 77.607  1.00 93.91  ? 1014 GLU D OE1 1 
ATOM   7062 O OE2 . GLU D 1 164 ? -106.289 28.861 78.765  1.00 95.54  ? 1014 GLU D OE2 1 
ATOM   7063 N N   . GLY D 1 165 ? -102.678 33.077 81.046  1.00 72.16  ? 1015 GLY D N   1 
ATOM   7064 C CA  . GLY D 1 165 ? -101.508 33.959 80.924  1.00 65.52  ? 1015 GLY D CA  1 
ATOM   7065 C C   . GLY D 1 165 ? -101.868 35.375 80.537  1.00 59.47  ? 1015 GLY D C   1 
ATOM   7066 O O   . GLY D 1 165 ? -100.994 36.053 80.007  1.00 59.17  ? 1015 GLY D O   1 
ATOM   7067 N N   . ASP D 1 166 ? -103.081 35.818 80.834  1.00 59.90  ? 1016 ASP D N   1 
ATOM   7068 C CA  . ASP D 1 166 ? -103.567 37.150 80.407  1.00 55.97  ? 1016 ASP D CA  1 
ATOM   7069 C C   . ASP D 1 166 ? -103.372 38.200 81.493  1.00 51.05  ? 1016 ASP D C   1 
ATOM   7070 O O   . ASP D 1 166 ? -103.439 39.385 81.186  1.00 47.26  ? 1016 ASP D O   1 
ATOM   7071 C CB  . ASP D 1 166 ? -105.056 37.081 80.092  1.00 62.70  ? 1016 ASP D CB  1 
ATOM   7072 C CG  . ASP D 1 166 ? -105.868 36.453 81.210  1.00 66.84  ? 1016 ASP D CG  1 
ATOM   7073 O OD1 . ASP D 1 166 ? -105.707 35.242 81.443  1.00 71.30  ? 1016 ASP D OD1 1 
ATOM   7074 O OD2 . ASP D 1 166 ? -106.633 37.186 81.855  1.00 68.01  ? 1016 ASP D OD2 1 
ATOM   7075 N N   . SER D 1 167 ? -103.241 37.752 82.732  1.00 52.14  ? 1017 SER D N   1 
ATOM   7076 C CA  . SER D 1 167 ? -103.081 38.708 83.843  1.00 40.98  ? 1017 SER D CA  1 
ATOM   7077 C C   . SER D 1 167 ? -102.161 38.090 84.888  1.00 42.39  ? 1017 SER D C   1 
ATOM   7078 O O   . SER D 1 167 ? -102.005 36.875 84.895  1.00 49.04  ? 1017 SER D O   1 
ATOM   7079 C CB  . SER D 1 167 ? -104.394 39.085 84.434  1.00 57.53  ? 1017 SER D CB  1 
ATOM   7080 O OG  . SER D 1 167 ? -104.970 37.985 85.114  1.00 58.05  ? 1017 SER D OG  1 
ATOM   7081 N N   . GLY D 1 168 ? -101.590 38.934 85.729  1.00 42.66  ? 1018 GLY D N   1 
ATOM   7082 C CA  . GLY D 1 168 ? -100.697 38.426 86.769  1.00 43.03  ? 1018 GLY D CA  1 
ATOM   7083 C C   . GLY D 1 168 ? -100.017 39.494 87.591  1.00 36.10  ? 1018 GLY D C   1 
ATOM   7084 O O   . GLY D 1 168 ? -100.385 40.657 87.481  1.00 40.78  ? 1018 GLY D O   1 
ATOM   7085 N N   . ARG D 1 169 ? -99.088  39.055 88.437  1.00 39.75  ? 1019 ARG D N   1 
ATOM   7086 C CA  . ARG D 1 169 ? -98.312  39.970 89.301  1.00 42.60  ? 1019 ARG D CA  1 
ATOM   7087 C C   . ARG D 1 169 ? -96.816  39.730 89.073  1.00 38.73  ? 1019 ARG D C   1 
ATOM   7088 O O   . ARG D 1 169 ? -96.404  38.580 89.109  1.00 40.67  ? 1019 ARG D O   1 
ATOM   7089 C CB  . ARG D 1 169 ? -98.632  39.739 90.776  1.00 42.71  ? 1019 ARG D CB  1 
ATOM   7090 C CG  . ARG D 1 169 ? -99.859  40.471 91.295  1.00 58.76  ? 1019 ARG D CG  1 
ATOM   7091 C CD  . ARG D 1 169 ? -100.430 39.681 92.457  1.00 62.52  ? 1019 ARG D CD  1 
ATOM   7092 N NE  . ARG D 1 169 ? -101.246 40.463 93.368  1.00 71.57  ? 1019 ARG D NE  1 
ATOM   7093 C CZ  . ARG D 1 169 ? -101.067 40.510 94.681  1.00 63.53  ? 1019 ARG D CZ  1 
ATOM   7094 N NH1 . ARG D 1 169 ? -100.277 39.633 95.271  1.00 64.09  ? 1019 ARG D NH1 1 
ATOM   7095 N NH2 . ARG D 1 169 ? -101.695 41.422 95.399  1.00 61.89  ? 1019 ARG D NH2 1 
ATOM   7096 N N   . LEU D 1 170 ? -96.066  40.808 88.856  1.00 37.57  ? 1020 LEU D N   1 
ATOM   7097 C CA  . LEU D 1 170 ? -94.614  40.710 88.576  1.00 36.85  ? 1020 LEU D CA  1 
ATOM   7098 C C   . LEU D 1 170 ? -93.855  41.428 89.683  1.00 31.13  ? 1020 LEU D C   1 
ATOM   7099 O O   . LEU D 1 170 ? -94.250  42.514 90.071  1.00 36.81  ? 1020 LEU D O   1 
ATOM   7100 C CB  . LEU D 1 170 ? -94.323  41.372 87.227  1.00 36.19  ? 1020 LEU D CB  1 
ATOM   7101 C CG  . LEU D 1 170 ? -95.016  40.784 86.003  1.00 32.59  ? 1020 LEU D CG  1 
ATOM   7102 C CD1 . LEU D 1 170 ? -94.541  41.489 84.744  1.00 37.10  ? 1020 LEU D CD1 1 
ATOM   7103 C CD2 . LEU D 1 170 ? -94.760  39.294 85.904  1.00 37.37  ? 1020 LEU D CD2 1 
ATOM   7104 N N   . LEU D 1 171 ? -92.774  40.810 90.132  1.00 36.94  ? 1021 LEU D N   1 
ATOM   7105 C CA  . LEU D 1 171 ? -91.947  41.398 91.202  1.00 34.73  ? 1021 LEU D CA  1 
ATOM   7106 C C   . LEU D 1 171 ? -91.082  42.525 90.670  1.00 36.74  ? 1021 LEU D C   1 
ATOM   7107 O O   . LEU D 1 171 ? -90.667  42.431 89.526  1.00 38.35  ? 1021 LEU D O   1 
ATOM   7108 C CB  . LEU D 1 171 ? -91.021  40.310 91.731  1.00 41.11  ? 1021 LEU D CB  1 
ATOM   7109 C CG  . LEU D 1 171 ? -91.680  39.260 92.623  1.00 53.12  ? 1021 LEU D CG  1 
ATOM   7110 C CD1 . LEU D 1 171 ? -90.884  37.965 92.630  1.00 54.13  ? 1021 LEU D CD1 1 
ATOM   7111 C CD2 . LEU D 1 171 ? -91.857  39.788 94.035  1.00 50.85  ? 1021 LEU D CD2 1 
ATOM   7112 N N   . TRP D 1 172 ? -90.862  43.543 91.485  1.00 36.12  ? 1022 TRP D N   1 
ATOM   7113 C CA  . TRP D 1 172 ? -89.885  44.584 91.121  1.00 38.56  ? 1022 TRP D CA  1 
ATOM   7114 C C   . TRP D 1 172 ? -88.682  44.415 92.050  1.00 41.52  ? 1022 TRP D C   1 
ATOM   7115 O O   . TRP D 1 172 ? -88.873  44.463 93.266  1.00 35.23  ? 1022 TRP D O   1 
ATOM   7116 C CB  . TRP D 1 172 ? -90.470  45.981 91.222  1.00 33.72  ? 1022 TRP D CB  1 
ATOM   7117 C CG  . TRP D 1 172 ? -89.505  47.095 90.983  1.00 33.02  ? 1022 TRP D CG  1 
ATOM   7118 C CD1 . TRP D 1 172 ? -89.086  48.029 91.882  1.00 35.81  ? 1022 TRP D CD1 1 
ATOM   7119 C CD2 . TRP D 1 172 ? -88.877  47.426 89.736  1.00 35.31  ? 1022 TRP D CD2 1 
ATOM   7120 N NE1 . TRP D 1 172 ? -88.223  48.905 91.285  1.00 41.86  ? 1022 TRP D NE1 1 
ATOM   7121 C CE2 . TRP D 1 172 ? -88.077  48.560 89.970  1.00 36.63  ? 1022 TRP D CE2 1 
ATOM   7122 C CE3 . TRP D 1 172 ? -88.907  46.869 88.456  1.00 35.94  ? 1022 TRP D CE3 1 
ATOM   7123 C CZ2 . TRP D 1 172 ? -87.314  49.145 88.964  1.00 38.78  ? 1022 TRP D CZ2 1 
ATOM   7124 C CZ3 . TRP D 1 172 ? -88.153  47.448 87.464  1.00 33.97  ? 1022 TRP D CZ3 1 
ATOM   7125 C CH2 . TRP D 1 172 ? -87.368  48.569 87.718  1.00 34.11  ? 1022 TRP D CH2 1 
ATOM   7126 N N   . LYS D 1 173 ? -87.511  44.211 91.464  1.00 38.08  ? 1023 LYS D N   1 
ATOM   7127 C CA  . LYS D 1 173 ? -86.256  44.036 92.223  1.00 38.07  ? 1023 LYS D CA  1 
ATOM   7128 C C   . LYS D 1 173 ? -85.268  45.111 91.758  1.00 39.94  ? 1023 LYS D C   1 
ATOM   7129 O O   . LYS D 1 173 ? -84.104  44.808 91.644  1.00 40.77  ? 1023 LYS D O   1 
ATOM   7130 C CB  . LYS D 1 173 ? -85.751  42.626 91.937  1.00 43.20  ? 1023 LYS D CB  1 
ATOM   7131 C CG  . LYS D 1 173 ? -86.581  41.459 92.450  1.00 47.33  ? 1023 LYS D CG  1 
ATOM   7132 C CD  . LYS D 1 173 ? -86.110  40.130 91.884  1.00 55.40  ? 1023 LYS D CD  1 
ATOM   7133 C CE  . LYS D 1 173 ? -86.772  38.922 92.514  1.00 56.58  ? 1023 LYS D CE  1 
ATOM   7134 N NZ  . LYS D 1 173 ? -86.577  37.686 91.719  1.00 47.31  ? 1023 LYS D NZ  1 
ATOM   7135 N N   . ASP D 1 174 ? -85.759  46.305 91.469  1.00 37.29  ? 1024 ASP D N   1 
ATOM   7136 C CA  . ASP D 1 174 ? -84.913  47.430 91.005  1.00 41.19  ? 1024 ASP D CA  1 
ATOM   7137 C C   . ASP D 1 174 ? -84.080  46.963 89.811  1.00 40.49  ? 1024 ASP D C   1 
ATOM   7138 O O   . ASP D 1 174 ? -82.912  47.321 89.726  1.00 38.91  ? 1024 ASP D O   1 
ATOM   7139 C CB  . ASP D 1 174 ? -84.090  48.029 92.144  1.00 44.47  ? 1024 ASP D CB  1 
ATOM   7140 C CG  . ASP D 1 174 ? -83.576  49.421 91.825  1.00 51.05  ? 1024 ASP D CG  1 
ATOM   7141 O OD1 . ASP D 1 174 ? -84.036  49.997 90.826  1.00 53.83  ? 1024 ASP D OD1 1 
ATOM   7142 O OD2 . ASP D 1 174 ? -82.734  49.922 92.588  1.00 62.42  ? 1024 ASP D OD2 1 
ATOM   7143 N N   . ASN D 1 175 ? -84.702  46.196 88.937  1.00 34.15  ? 1025 ASN D N   1 
ATOM   7144 C CA  . ASN D 1 175 ? -83.993  45.683 87.768  1.00 33.18  ? 1025 ASN D CA  1 
ATOM   7145 C C   . ASN D 1 175 ? -84.917  45.797 86.563  1.00 32.28  ? 1025 ASN D C   1 
ATOM   7146 O O   . ASN D 1 175 ? -85.878  45.030 86.448  1.00 32.04  ? 1025 ASN D O   1 
ATOM   7147 C CB  . ASN D 1 175 ? -83.558  44.233 87.987  1.00 32.03  ? 1025 ASN D CB  1 
ATOM   7148 C CG  . ASN D 1 175 ? -82.622  43.729 86.906  1.00 35.30  ? 1025 ASN D CG  1 
ATOM   7149 O OD1 . ASN D 1 175 ? -82.884  43.887 85.714  1.00 32.40  ? 1025 ASN D OD1 1 
ATOM   7150 N ND2 . ASN D 1 175 ? -81.532  43.094 87.320  1.00 33.62  ? 1025 ASN D ND2 1 
ATOM   7151 N N   . TRP D 1 176 ? -84.635  46.746 85.665  1.00 30.52  ? 1026 TRP D N   1 
ATOM   7152 C CA  . TRP D 1 176 ? -85.492  46.916 84.494  1.00 33.40  ? 1026 TRP D CA  1 
ATOM   7153 C C   . TRP D 1 176 ? -85.397  45.737 83.537  1.00 32.88  ? 1026 TRP D C   1 
ATOM   7154 O O   . TRP D 1 176 ? -86.393  45.378 82.893  1.00 31.35  ? 1026 TRP D O   1 
ATOM   7155 C CB  . TRP D 1 176 ? -85.123  48.191 83.740  1.00 28.30  ? 1026 TRP D CB  1 
ATOM   7156 C CG  . TRP D 1 176 ? -85.527  49.445 84.411  1.00 26.88  ? 1026 TRP D CG  1 
ATOM   7157 C CD1 . TRP D 1 176 ? -84.724  50.311 85.090  1.00 32.59  ? 1026 TRP D CD1 1 
ATOM   7158 C CD2 . TRP D 1 176 ? -86.847  49.984 84.472  1.00 28.11  ? 1026 TRP D CD2 1 
ATOM   7159 N NE1 . TRP D 1 176 ? -85.465  51.366 85.565  1.00 32.07  ? 1026 TRP D NE1 1 
ATOM   7160 C CE2 . TRP D 1 176 ? -86.774  51.186 85.200  1.00 30.89  ? 1026 TRP D CE2 1 
ATOM   7161 C CE3 . TRP D 1 176 ? -88.087  49.566 83.980  1.00 31.57  ? 1026 TRP D CE3 1 
ATOM   7162 C CZ2 . TRP D 1 176 ? -87.893  51.975 85.448  1.00 33.55  ? 1026 TRP D CZ2 1 
ATOM   7163 C CZ3 . TRP D 1 176 ? -89.195  50.349 84.226  1.00 31.46  ? 1026 TRP D CZ3 1 
ATOM   7164 C CH2 . TRP D 1 176 ? -89.092  51.540 84.954  1.00 31.25  ? 1026 TRP D CH2 1 
ATOM   7165 N N   . VAL D 1 177 ? -84.218  45.120 83.438  1.00 28.43  ? 1027 VAL D N   1 
ATOM   7166 C CA  . VAL D 1 177 ? -84.012  44.057 82.460  1.00 28.75  ? 1027 VAL D CA  1 
ATOM   7167 C C   . VAL D 1 177 ? -84.845  42.835 82.819  1.00 33.02  ? 1027 VAL D C   1 
ATOM   7168 O O   . VAL D 1 177 ? -85.596  42.305 81.989  1.00 30.06  ? 1027 VAL D O   1 
ATOM   7169 C CB  . VAL D 1 177 ? -82.515  43.713 82.356  1.00 27.26  ? 1027 VAL D CB  1 
ATOM   7170 C CG1 . VAL D 1 177 ? -82.319  42.450 81.539  1.00 26.09  ? 1027 VAL D CG1 1 
ATOM   7171 C CG2 . VAL D 1 177 ? -81.749  44.872 81.745  1.00 29.44  ? 1027 VAL D CG2 1 
ATOM   7172 N N   . SER D 1 178 ? -84.765  42.396 84.076  1.00 31.35  ? 1028 SER D N   1 
ATOM   7173 C CA  . SER D 1 178 ? -85.517  41.215 84.480  1.00 34.53  ? 1028 SER D CA  1 
ATOM   7174 C C   . SER D 1 178 ? -87.013  41.503 84.564  1.00 29.49  ? 1028 SER D C   1 
ATOM   7175 O O   . SER D 1 178 ? -87.828  40.631 84.236  1.00 35.05  ? 1028 SER D O   1 
ATOM   7176 C CB  . SER D 1 178 ? -84.988  40.689 85.815  1.00 29.99  ? 1028 SER D CB  1 
ATOM   7177 O OG  . SER D 1 178 ? -85.134  41.653 86.841  1.00 34.74  ? 1028 SER D OG  1 
ATOM   7178 N N   . PHE D 1 179 ? -87.395  42.716 84.976  1.00 30.78  ? 1029 PHE D N   1 
ATOM   7179 C CA  . PHE D 1 179 ? -88.813  43.074 85.005  1.00 33.94  ? 1029 PHE D CA  1 
ATOM   7180 C C   . PHE D 1 179 ? -89.436  42.989 83.610  1.00 34.95  ? 1029 PHE D C   1 
ATOM   7181 O O   . PHE D 1 179 ? -90.460  42.310 83.398  1.00 31.24  ? 1029 PHE D O   1 
ATOM   7182 C CB  . PHE D 1 179 ? -88.986  44.479 85.590  1.00 29.68  ? 1029 PHE D CB  1 
ATOM   7183 C CG  . PHE D 1 179 ? -90.421  44.907 85.706  1.00 35.61  ? 1029 PHE D CG  1 
ATOM   7184 C CD1 . PHE D 1 179 ? -91.186  44.514 86.791  1.00 38.63  ? 1029 PHE D CD1 1 
ATOM   7185 C CD2 . PHE D 1 179 ? -91.013  45.679 84.718  1.00 30.24  ? 1029 PHE D CD2 1 
ATOM   7186 C CE1 . PHE D 1 179 ? -92.512  44.893 86.898  1.00 36.31  ? 1029 PHE D CE1 1 
ATOM   7187 C CE2 . PHE D 1 179 ? -92.340  46.060 84.818  1.00 37.58  ? 1029 PHE D CE2 1 
ATOM   7188 C CZ  . PHE D 1 179 ? -93.090  45.667 85.910  1.00 40.19  ? 1029 PHE D CZ  1 
ATOM   7189 N N   . MET D 1 180 ? -88.827  43.665 82.632  1.00 33.91  ? 1030 MET D N   1 
ATOM   7190 C CA  . MET D 1 180 ? -89.402  43.592 81.294  1.00 31.11  ? 1030 MET D CA  1 
ATOM   7191 C C   . MET D 1 180 ? -89.310  42.180 80.722  1.00 30.41  ? 1030 MET D C   1 
ATOM   7192 O O   . MET D 1 180 ? -90.200  41.756 79.961  1.00 32.88  ? 1030 MET D O   1 
ATOM   7193 C CB  . MET D 1 180 ? -88.741  44.610 80.367  1.00 29.43  ? 1030 MET D CB  1 
ATOM   7194 C CG  . MET D 1 180 ? -88.699  46.020 80.921  1.00 33.02  ? 1030 MET D CG  1 
ATOM   7195 S SD  . MET D 1 180 ? -88.413  47.226 79.617  1.00 37.29  ? 1030 MET D SD  1 
ATOM   7196 C CE  . MET D 1 180 ? -86.640  47.398 79.767  1.00 35.42  ? 1030 MET D CE  1 
ATOM   7197 N N   . ASP D 1 181 ? -88.276  41.415 81.091  1.00 30.83  ? 1031 ASP D N   1 
ATOM   7198 C CA  . ASP D 1 181 ? -88.228  40.043 80.603  1.00 29.61  ? 1031 ASP D CA  1 
ATOM   7199 C C   . ASP D 1 181 ? -89.398  39.227 81.138  1.00 37.41  ? 1031 ASP D C   1 
ATOM   7200 O O   . ASP D 1 181 ? -89.925  38.360 80.434  1.00 36.10  ? 1031 ASP D O   1 
ATOM   7201 C CB  . ASP D 1 181 ? -86.905  39.367 80.950  1.00 32.05  ? 1031 ASP D CB  1 
ATOM   7202 C CG  . ASP D 1 181 ? -86.781  38.000 80.298  1.00 40.71  ? 1031 ASP D CG  1 
ATOM   7203 O OD1 . ASP D 1 181 ? -86.634  37.953 79.057  1.00 42.07  ? 1031 ASP D OD1 1 
ATOM   7204 O OD2 . ASP D 1 181 ? -86.852  36.976 81.010  1.00 39.06  ? 1031 ASP D OD2 1 
ATOM   7205 N N   . THR D 1 182 ? -89.812  39.465 82.388  1.00 34.53  ? 1032 THR D N   1 
ATOM   7206 C CA  . THR D 1 182 ? -90.975  38.729 82.883  1.00 32.41  ? 1032 THR D CA  1 
ATOM   7207 C C   . THR D 1 182 ? -92.275  39.180 82.213  1.00 36.52  ? 1032 THR D C   1 
ATOM   7208 O O   . THR D 1 182 ? -93.216  38.370 82.093  1.00 39.80  ? 1032 THR D O   1 
ATOM   7209 C CB  . THR D 1 182 ? -91.083  38.821 84.412  1.00 33.24  ? 1032 THR D CB  1 
ATOM   7210 O OG1 . THR D 1 182 ? -91.205  40.187 84.826  1.00 37.13  ? 1032 THR D OG1 1 
ATOM   7211 C CG2 . THR D 1 182 ? -89.863  38.185 85.073  1.00 34.34  ? 1032 THR D CG2 1 
ATOM   7212 N N   . MET D 1 183 ? -92.350  40.422 81.714  1.00 37.70  ? 1033 MET D N   1 
ATOM   7213 C CA  . MET D 1 183 ? -93.507  40.690 80.848  1.00 37.34  ? 1033 MET D CA  1 
ATOM   7214 C C   . MET D 1 183 ? -93.448  39.872 79.553  1.00 43.27  ? 1033 MET D C   1 
ATOM   7215 O O   . MET D 1 183 ? -94.483  39.380 79.089  1.00 40.08  ? 1033 MET D O   1 
ATOM   7216 C CB  . MET D 1 183 ? -93.742  42.179 80.555  1.00 34.90  ? 1033 MET D CB  1 
ATOM   7217 C CG  . MET D 1 183 ? -93.426  43.156 81.670  1.00 33.74  ? 1033 MET D CG  1 
ATOM   7218 S SD  . MET D 1 183 ? -93.090  44.831 81.097  1.00 37.29  ? 1033 MET D SD  1 
ATOM   7219 C CE  . MET D 1 183 ? -94.563  45.159 80.118  1.00 36.58  ? 1033 MET D CE  1 
ATOM   7220 N N   . LEU D 1 184 ? -92.265  39.703 78.952  1.00 39.63  ? 1034 LEU D N   1 
ATOM   7221 C CA  . LEU D 1 184 ? -92.204  38.803 77.787  1.00 37.43  ? 1034 LEU D CA  1 
ATOM   7222 C C   . LEU D 1 184 ? -92.563  37.357 78.169  1.00 46.14  ? 1034 LEU D C   1 
ATOM   7223 O O   . LEU D 1 184 ? -93.181  36.608 77.378  1.00 43.29  ? 1034 LEU D O   1 
ATOM   7224 C CB  . LEU D 1 184 ? -90.819  38.854 77.136  1.00 39.21  ? 1034 LEU D CB  1 
ATOM   7225 C CG  . LEU D 1 184 ? -90.270  40.212 76.687  1.00 40.12  ? 1034 LEU D CG  1 
ATOM   7226 C CD1 . LEU D 1 184 ? -89.099  40.014 75.733  1.00 39.89  ? 1034 LEU D CD1 1 
ATOM   7227 C CD2 . LEU D 1 184 ? -91.351  41.076 76.051  1.00 44.91  ? 1034 LEU D CD2 1 
ATOM   7228 N N   . GLN D 1 185 ? -92.203  36.959 79.389  1.00 44.41  ? 1035 GLN D N   1 
ATOM   7229 C CA  . GLN D 1 185 ? -92.539  35.624 79.873  1.00 41.27  ? 1035 GLN D CA  1 
ATOM   7230 C C   . GLN D 1 185 ? -94.047  35.402 79.901  1.00 42.50  ? 1035 GLN D C   1 
ATOM   7231 O O   . GLN D 1 185 ? -94.521  34.303 79.583  1.00 46.39  ? 1035 GLN D O   1 
ATOM   7232 C CB  . GLN D 1 185 ? -91.943  35.391 81.262  1.00 42.21  ? 1035 GLN D CB  1 
ATOM   7233 C CG  . GLN D 1 185 ? -90.428  35.260 81.295  1.00 39.81  ? 1035 GLN D CG  1 
ATOM   7234 C CD  . GLN D 1 185 ? -89.888  35.210 82.712  1.00 44.76  ? 1035 GLN D CD  1 
ATOM   7235 O OE1 . GLN D 1 185 ? -90.609  34.865 83.648  1.00 38.84  ? 1035 GLN D OE1 1 
ATOM   7236 N NE2 . GLN D 1 185 ? -88.618  35.560 82.878  1.00 36.25  ? 1035 GLN D NE2 1 
ATOM   7237 N N   . MET D 1 186 ? -94.819  36.423 80.293  1.00 43.48  ? 1036 MET D N   1 
ATOM   7238 C CA  . MET D 1 186 ? -96.277  36.247 80.317  1.00 47.05  ? 1036 MET D CA  1 
ATOM   7239 C C   . MET D 1 186 ? -96.845  35.871 78.947  1.00 57.05  ? 1036 MET D C   1 
ATOM   7240 O O   . MET D 1 186 ? -97.712  34.993 78.853  1.00 55.92  ? 1036 MET D O   1 
ATOM   7241 C CB  . MET D 1 186 ? -96.975  37.502 80.834  1.00 40.30  ? 1036 MET D CB  1 
ATOM   7242 C CG  . MET D 1 186 ? -96.559  37.932 82.215  1.00 42.62  ? 1036 MET D CG  1 
ATOM   7243 S SD  . MET D 1 186 ? -97.376  36.873 83.425  1.00 50.43  ? 1036 MET D SD  1 
ATOM   7244 C CE  . MET D 1 186 ? -99.088  37.337 83.175  1.00 47.10  ? 1036 MET D CE  1 
ATOM   7245 N N   . SER D 1 187 ? -96.398  36.538 77.878  1.00 48.93  ? 1037 SER D N   1 
ATOM   7246 C CA  . SER D 1 187 ? -96.858  36.158 76.544  1.00 54.19  ? 1037 SER D CA  1 
ATOM   7247 C C   . SER D 1 187 ? -96.452  34.734 76.219  1.00 59.41  ? 1037 SER D C   1 
ATOM   7248 O O   . SER D 1 187 ? -97.176  34.019 75.511  1.00 60.85  ? 1037 SER D O   1 
ATOM   7249 C CB  . SER D 1 187 ? -96.289  37.105 75.489  1.00 57.59  ? 1037 SER D CB  1 
ATOM   7250 O OG  . SER D 1 187 ? -96.282  38.442 75.947  1.00 59.17  ? 1037 SER D OG  1 
ATOM   7251 N N   . ILE D 1 188 ? -95.411  34.226 76.855  1.00 57.19  ? 1038 ILE D N   1 
ATOM   7252 C CA  . ILE D 1 188 ? -94.940  32.852 76.528  1.00 59.95  ? 1038 ILE D CA  1 
ATOM   7253 C C   . ILE D 1 188 ? -95.867  31.849 77.207  1.00 69.56  ? 1038 ILE D C   1 
ATOM   7254 O O   . ILE D 1 188 ? -96.035  30.745 76.675  1.00 70.84  ? 1038 ILE D O   1 
ATOM   7255 C CB  . ILE D 1 188 ? -93.470  32.631 76.935  1.00 58.53  ? 1038 ILE D CB  1 
ATOM   7256 C CG1 . ILE D 1 188 ? -92.516  33.475 76.089  1.00 58.00  ? 1038 ILE D CG1 1 
ATOM   7257 C CG2 . ILE D 1 188 ? -93.104  31.159 76.879  1.00 61.48  ? 1038 ILE D CG2 1 
ATOM   7258 C CD1 . ILE D 1 188 ? -91.068  33.336 76.484  1.00 55.90  ? 1038 ILE D CD1 1 
ATOM   7259 N N   . LEU D 1 189 ? -96.456  32.233 78.330  1.00 67.23  ? 1039 LEU D N   1 
ATOM   7260 C CA  . LEU D 1 189 ? -97.295  31.285 79.103  1.00 69.37  ? 1039 LEU D CA  1 
ATOM   7261 C C   . LEU D 1 189 ? -98.604  31.088 78.351  1.00 70.06  ? 1039 LEU D C   1 
ATOM   7262 O O   . LEU D 1 189 ? -99.039  29.942 78.225  1.00 76.80  ? 1039 LEU D O   1 
ATOM   7263 C CB  . LEU D 1 189 ? -97.513  31.876 80.496  1.00 65.57  ? 1039 LEU D CB  1 
ATOM   7264 C CG  . LEU D 1 189 ? -97.822  30.905 81.629  1.00 63.30  ? 1039 LEU D CG  1 
ATOM   7265 C CD1 . LEU D 1 189 ? -96.758  29.828 81.726  1.00 61.21  ? 1039 LEU D CD1 1 
ATOM   7266 C CD2 . LEU D 1 189 ? -97.913  31.669 82.937  1.00 62.80  ? 1039 LEU D CD2 1 
ATOM   7267 N N   . GLY D 1 190 ? -99.177  32.169 77.845  1.00 69.78  ? 1040 GLY D N   1 
ATOM   7268 C CA  . GLY D 1 190 ? -100.447 32.078 77.106  1.00 73.25  ? 1040 GLY D CA  1 
ATOM   7269 C C   . GLY D 1 190 ? -100.212 31.743 75.651  1.00 80.65  ? 1040 GLY D C   1 
ATOM   7270 O O   . GLY D 1 190 ? -101.058 32.125 74.826  1.00 82.48  ? 1040 GLY D O   1 
ATOM   7271 N N   . SER D 1 191 ? -99.107  31.055 75.346  1.00 80.49  ? 1041 SER D N   1 
ATOM   7272 C CA  . SER D 1 191 ? -98.734  30.803 73.930  1.00 80.78  ? 1041 SER D CA  1 
ATOM   7273 C C   . SER D 1 191 ? -99.582  29.707 73.311  1.00 82.59  ? 1041 SER D C   1 
ATOM   7274 O O   . SER D 1 191 ? -99.427  28.534 73.687  1.00 78.71  ? 1041 SER D O   1 
ATOM   7275 C CB  . SER D 1 191 ? -97.289  30.461 73.760  1.00 78.98  ? 1041 SER D CB  1 
ATOM   7276 O OG  . SER D 1 191 ? -97.032  30.085 72.421  1.00 82.20  ? 1041 SER D OG  1 
ATOM   7277 N N   . ALA D 1 192 ? -100.394 30.110 72.352  1.00 82.49  ? 1042 ALA D N   1 
ATOM   7278 C CA  . ALA D 1 192 ? -101.167 29.118 71.606  1.00 85.43  ? 1042 ALA D CA  1 
ATOM   7279 C C   . ALA D 1 192 ? -100.155 28.261 70.832  1.00 87.47  ? 1042 ALA D C   1 
ATOM   7280 O O   . ALA D 1 192 ? -100.561 27.282 70.208  1.00 89.02  ? 1042 ALA D O   1 
ATOM   7281 C CB  . ALA D 1 192 ? -102.121 29.871 70.723  1.00 81.24  ? 1042 ALA D CB  1 
ATOM   7282 N N   . LYS D 1 193 ? -98.867  28.611 70.896  1.00 84.99  ? 1043 LYS D N   1 
ATOM   7283 C CA  . LYS D 1 193 ? -97.860  27.869 70.093  1.00 85.13  ? 1043 LYS D CA  1 
ATOM   7284 C C   . LYS D 1 193 ? -96.908  27.093 71.002  1.00 82.41  ? 1043 LYS D C   1 
ATOM   7285 O O   . LYS D 1 193 ? -96.890  27.358 72.195  1.00 87.06  ? 1043 LYS D O   1 
ATOM   7286 C CB  . LYS D 1 193 ? -97.157  28.788 69.084  1.00 85.03  ? 1043 LYS D CB  1 
ATOM   7287 C CG  . LYS D 1 193 ? -96.733  30.165 69.566  1.00 83.17  ? 1043 LYS D CG  1 
ATOM   7288 C CD  . LYS D 1 193 ? -96.162  31.010 68.447  1.00 78.15  ? 1043 LYS D CD  1 
ATOM   7289 C CE  . LYS D 1 193 ? -95.439  32.248 68.931  1.00 73.32  ? 1043 LYS D CE  1 
ATOM   7290 N NZ  . LYS D 1 193 ? -94.928  33.056 67.800  1.00 66.96  ? 1043 LYS D NZ  1 
ATOM   7291 N N   . HIS D 1 194 ? -96.183  26.135 70.441  1.00 85.02  ? 1044 HIS D N   1 
ATOM   7292 C CA  . HIS D 1 194 ? -95.312  25.258 71.259  1.00 84.60  ? 1044 HIS D CA  1 
ATOM   7293 C C   . HIS D 1 194 ? -93.941  25.141 70.606  1.00 82.72  ? 1044 HIS D C   1 
ATOM   7294 O O   . HIS D 1 194 ? -93.849  25.209 69.364  1.00 81.20  ? 1044 HIS D O   1 
ATOM   7295 C CB  . HIS D 1 194 ? -95.931  23.869 71.452  1.00 91.83  ? 1044 HIS D CB  1 
ATOM   7296 C CG  . HIS D 1 194 ? -96.720  23.335 70.304  1.00 96.85  ? 1044 HIS D CG  1 
ATOM   7297 N ND1 . HIS D 1 194 ? -97.332  22.102 70.371  1.00 102.06 ? 1044 HIS D ND1 1 
ATOM   7298 C CD2 . HIS D 1 194 ? -97.014  23.827 69.096  1.00 98.90  ? 1044 HIS D CD2 1 
ATOM   7299 C CE1 . HIS D 1 194 ? -97.965  21.866 69.232  1.00 102.27 ? 1044 HIS D CE1 1 
ATOM   7300 N NE2 . HIS D 1 194 ? -97.787  22.903 68.444  1.00 101.84 ? 1044 HIS D NE2 1 
ATOM   7301 N N   . GLY D 1 195 ? -92.915  24.928 71.422  1.00 80.63  ? 1045 GLY D N   1 
ATOM   7302 C CA  . GLY D 1 195 ? -91.535  24.925 70.910  1.00 76.37  ? 1045 GLY D CA  1 
ATOM   7303 C C   . GLY D 1 195 ? -90.813  26.200 71.313  1.00 69.60  ? 1045 GLY D C   1 
ATOM   7304 O O   . GLY D 1 195 ? -91.458  27.084 71.885  1.00 66.66  ? 1045 GLY D O   1 
ATOM   7305 N N   . LEU D 1 196 ? -89.517  26.272 71.027  1.00 67.26  ? 1046 LEU D N   1 
ATOM   7306 C CA  . LEU D 1 196 ? -88.705  27.450 71.415  1.00 68.18  ? 1046 LEU D CA  1 
ATOM   7307 C C   . LEU D 1 196 ? -88.909  28.600 70.438  1.00 64.50  ? 1046 LEU D C   1 
ATOM   7308 O O   . LEU D 1 196 ? -88.641  28.424 69.253  1.00 66.54  ? 1046 LEU D O   1 
ATOM   7309 C CB  . LEU D 1 196 ? -87.227  27.070 71.473  1.00 63.33  ? 1046 LEU D CB  1 
ATOM   7310 C CG  . LEU D 1 196 ? -86.279  28.245 71.698  1.00 69.84  ? 1046 LEU D CG  1 
ATOM   7311 C CD1 . LEU D 1 196 ? -86.500  28.862 73.067  1.00 63.12  ? 1046 LEU D CD1 1 
ATOM   7312 C CD2 . LEU D 1 196 ? -84.832  27.819 71.530  1.00 65.57  ? 1046 LEU D CD2 1 
ATOM   7313 N N   . TYR D 1 197 ? -89.414  29.705 70.942  1.00 62.92  ? 1047 TYR D N   1 
ATOM   7314 C CA  . TYR D 1 197 ? -89.540  30.924 70.147  1.00 62.82  ? 1047 TYR D CA  1 
ATOM   7315 C C   . TYR D 1 197 ? -88.772  32.066 70.805  1.00 59.48  ? 1047 TYR D C   1 
ATOM   7316 O O   . TYR D 1 197 ? -88.637  32.104 72.031  1.00 59.27  ? 1047 TYR D O   1 
ATOM   7317 C CB  . TYR D 1 197 ? -91.012  31.320 69.962  1.00 62.89  ? 1047 TYR D CB  1 
ATOM   7318 C CG  . TYR D 1 197 ? -91.763  30.449 68.975  1.00 67.14  ? 1047 TYR D CG  1 
ATOM   7319 C CD1 . TYR D 1 197 ? -92.056  29.126 69.275  1.00 71.78  ? 1047 TYR D CD1 1 
ATOM   7320 C CD2 . TYR D 1 197 ? -92.191  30.950 67.755  1.00 65.63  ? 1047 TYR D CD2 1 
ATOM   7321 C CE1 . TYR D 1 197 ? -92.742  28.325 68.381  1.00 69.48  ? 1047 TYR D CE1 1 
ATOM   7322 C CE2 . TYR D 1 197 ? -92.864  30.153 66.847  1.00 66.01  ? 1047 TYR D CE2 1 
ATOM   7323 C CZ  . TYR D 1 197 ? -93.143  28.843 67.169  1.00 70.85  ? 1047 TYR D CZ  1 
ATOM   7324 O OH  . TYR D 1 197 ? -93.825  28.048 66.277  1.00 78.86  ? 1047 TYR D OH  1 
ATOM   7325 N N   . LEU D 1 198 ? -88.170  32.928 69.989  1.00 55.89  ? 1048 LEU D N   1 
ATOM   7326 C CA  . LEU D 1 198 ? -87.454  34.102 70.461  1.00 51.92  ? 1048 LEU D CA  1 
ATOM   7327 C C   . LEU D 1 198 ? -87.971  35.382 69.813  1.00 48.85  ? 1048 LEU D C   1 
ATOM   7328 O O   . LEU D 1 198 ? -88.458  35.356 68.675  1.00 48.26  ? 1048 LEU D O   1 
ATOM   7329 C CB  . LEU D 1 198 ? -85.950  33.947 70.209  1.00 50.68  ? 1048 LEU D CB  1 
ATOM   7330 C CG  . LEU D 1 198 ? -85.350  32.853 71.098  1.00 51.86  ? 1048 LEU D CG  1 
ATOM   7331 C CD1 . LEU D 1 198 ? -83.998  32.397 70.579  1.00 49.83  ? 1048 LEU D CD1 1 
ATOM   7332 C CD2 . LEU D 1 198 ? -85.249  33.324 72.542  1.00 49.42  ? 1048 LEU D CD2 1 
ATOM   7333 N N   . PRO D 1 199 ? -87.878  36.516 70.516  1.00 48.48  ? 1049 PRO D N   1 
ATOM   7334 C CA  . PRO D 1 199 ? -88.326  37.789 69.934  1.00 45.64  ? 1049 PRO D CA  1 
ATOM   7335 C C   . PRO D 1 199 ? -87.482  38.182 68.730  1.00 45.75  ? 1049 PRO D C   1 
ATOM   7336 O O   . PRO D 1 199 ? -86.253  38.081 68.751  1.00 41.77  ? 1049 PRO D O   1 
ATOM   7337 C CB  . PRO D 1 199 ? -88.142  38.787 71.086  1.00 46.42  ? 1049 PRO D CB  1 
ATOM   7338 C CG  . PRO D 1 199 ? -88.126  37.942 72.322  1.00 49.67  ? 1049 PRO D CG  1 
ATOM   7339 C CD  . PRO D 1 199 ? -87.423  36.687 71.905  1.00 49.56  ? 1049 PRO D CD  1 
ATOM   7340 N N   . THR D 1 200 ? -88.155  38.646 67.673  1.00 41.67  ? 1050 THR D N   1 
ATOM   7341 C CA  . THR D 1 200 ? -87.475  39.171 66.497  1.00 40.01  ? 1050 THR D CA  1 
ATOM   7342 C C   . THR D 1 200 ? -87.879  40.589 66.120  1.00 36.88  ? 1050 THR D C   1 
ATOM   7343 O O   . THR D 1 200 ? -87.135  41.242 65.380  1.00 41.88  ? 1050 THR D O   1 
ATOM   7344 C CB  . THR D 1 200 ? -87.700  38.255 65.282  1.00 45.20  ? 1050 THR D CB  1 
ATOM   7345 O OG1 . THR D 1 200 ? -89.087  38.261 64.923  1.00 48.33  ? 1050 THR D OG1 1 
ATOM   7346 C CG2 . THR D 1 200 ? -87.247  36.831 65.585  1.00 49.94  ? 1050 THR D CG2 1 
ATOM   7347 N N   . ARG D 1 201 ? -89.046  41.063 66.557  1.00 36.71  ? 1051 ARG D N   1 
ATOM   7348 C CA  . ARG D 1 201 ? -89.525  42.405 66.245  1.00 39.36  ? 1051 ARG D CA  1 
ATOM   7349 C C   . ARG D 1 201 ? -90.387  42.893 67.400  1.00 40.17  ? 1051 ARG D C   1 
ATOM   7350 O O   . ARG D 1 201 ? -91.079  42.104 68.049  1.00 42.30  ? 1051 ARG D O   1 
ATOM   7351 C CB  . ARG D 1 201 ? -90.349  42.458 64.948  1.00 44.83  ? 1051 ARG D CB  1 
ATOM   7352 C CG  . ARG D 1 201 ? -89.911  41.501 63.850  1.00 53.93  ? 1051 ARG D CG  1 
ATOM   7353 C CD  . ARG D 1 201 ? -90.414  41.934 62.491  1.00 60.04  ? 1051 ARG D CD  1 
ATOM   7354 N NE  . ARG D 1 201 ? -91.856  41.750 62.399  1.00 64.97  ? 1051 ARG D NE  1 
ATOM   7355 C CZ  . ARG D 1 201 ? -92.443  40.635 61.986  1.00 68.82  ? 1051 ARG D CZ  1 
ATOM   7356 N NH1 . ARG D 1 201 ? -91.737  39.576 61.622  1.00 72.14  ? 1051 ARG D NH1 1 
ATOM   7357 N NH2 . ARG D 1 201 ? -93.771  40.572 61.959  1.00 66.54  ? 1051 ARG D NH2 1 
ATOM   7358 N N   . VAL D 1 202 ? -90.326  44.198 67.666  1.00 35.48  ? 1052 VAL D N   1 
ATOM   7359 C CA  . VAL D 1 202 ? -91.237  44.852 68.603  1.00 35.60  ? 1052 VAL D CA  1 
ATOM   7360 C C   . VAL D 1 202 ? -91.636  46.190 67.999  1.00 38.01  ? 1052 VAL D C   1 
ATOM   7361 O O   . VAL D 1 202 ? -90.770  47.020 67.699  1.00 35.82  ? 1052 VAL D O   1 
ATOM   7362 C CB  . VAL D 1 202 ? -90.618  45.068 69.997  1.00 36.73  ? 1052 VAL D CB  1 
ATOM   7363 C CG1 . VAL D 1 202 ? -91.695  45.493 70.984  1.00 38.58  ? 1052 VAL D CG1 1 
ATOM   7364 C CG2 . VAL D 1 202 ? -89.905  43.817 70.492  1.00 40.04  ? 1052 VAL D CG2 1 
ATOM   7365 N N   . THR D 1 203 ? -92.941  46.411 67.833  1.00 35.09  ? 1053 THR D N   1 
ATOM   7366 C CA  . THR D 1 203 ? -93.395  47.622 67.157  1.00 34.40  ? 1053 THR D CA  1 
ATOM   7367 C C   . THR D 1 203 ? -93.135  48.867 67.999  1.00 36.20  ? 1053 THR D C   1 
ATOM   7368 O O   . THR D 1 203 ? -92.628  49.872 67.488  1.00 37.50  ? 1053 THR D O   1 
ATOM   7369 C CB  . THR D 1 203 ? -94.876  47.502 66.798  1.00 37.09  ? 1053 THR D CB  1 
ATOM   7370 O OG1 . THR D 1 203 ? -95.071  46.345 65.973  1.00 35.20  ? 1053 THR D OG1 1 
ATOM   7371 C CG2 . THR D 1 203 ? -95.348  48.742 66.053  1.00 37.12  ? 1053 THR D CG2 1 
ATOM   7372 N N   . ALA D 1 204 ? -93.454  48.823 69.293  1.00 32.18  ? 1054 ALA D N   1 
ATOM   7373 C CA  . ALA D 1 204 ? -93.238  50.008 70.115  1.00 30.02  ? 1054 ALA D CA  1 
ATOM   7374 C C   . ALA D 1 204 ? -93.134  49.626 71.585  1.00 37.99  ? 1054 ALA D C   1 
ATOM   7375 O O   . ALA D 1 204 ? -93.844  48.742 72.054  1.00 38.21  ? 1054 ALA D O   1 
ATOM   7376 C CB  . ALA D 1 204 ? -94.364  51.030 69.915  1.00 40.24  ? 1054 ALA D CB  1 
ATOM   7377 N N   . ILE D 1 205 ? -92.233  50.289 72.302  1.00 33.33  ? 1055 ILE D N   1 
ATOM   7378 C CA  . ILE D 1 205 ? -92.123  50.155 73.751  1.00 31.44  ? 1055 ILE D CA  1 
ATOM   7379 C C   . ILE D 1 205 ? -92.063  51.545 74.361  1.00 34.40  ? 1055 ILE D C   1 
ATOM   7380 O O   . ILE D 1 205 ? -91.216  52.357 73.980  1.00 34.47  ? 1055 ILE D O   1 
ATOM   7381 C CB  . ILE D 1 205 ? -90.890  49.332 74.173  1.00 32.67  ? 1055 ILE D CB  1 
ATOM   7382 C CG1 . ILE D 1 205 ? -91.004  47.901 73.650  1.00 35.73  ? 1055 ILE D CG1 1 
ATOM   7383 C CG2 . ILE D 1 205 ? -90.726  49.356 75.696  1.00 32.46  ? 1055 ILE D CG2 1 
ATOM   7384 C CD1 . ILE D 1 205 ? -89.690  47.174 73.550  1.00 43.70  ? 1055 ILE D CD1 1 
ATOM   7385 N N   . HIS D 1 206 ? -92.952  51.818 75.307  1.00 27.30  ? 1056 HIS D N   1 
ATOM   7386 C CA  . HIS D 1 206 ? -92.928  53.060 76.066  1.00 29.81  ? 1056 HIS D CA  1 
ATOM   7387 C C   . HIS D 1 206 ? -92.543  52.734 77.503  1.00 31.67  ? 1056 HIS D C   1 
ATOM   7388 O O   . HIS D 1 206 ? -93.063  51.774 78.084  1.00 33.64  ? 1056 HIS D O   1 
ATOM   7389 C CB  . HIS D 1 206 ? -94.287  53.768 76.030  1.00 34.76  ? 1056 HIS D CB  1 
ATOM   7390 C CG  . HIS D 1 206 ? -94.684  54.275 74.675  1.00 29.22  ? 1056 HIS D CG  1 
ATOM   7391 N ND1 . HIS D 1 206 ? -95.038  53.436 73.639  1.00 33.44  ? 1056 HIS D ND1 1 
ATOM   7392 C CD2 . HIS D 1 206 ? -94.807  55.535 74.194  1.00 33.98  ? 1056 HIS D CD2 1 
ATOM   7393 C CE1 . HIS D 1 206 ? -95.353  54.157 72.578  1.00 35.29  ? 1056 HIS D CE1 1 
ATOM   7394 N NE2 . HIS D 1 206 ? -95.220  55.434 72.888  1.00 31.85  ? 1056 HIS D NE2 1 
ATOM   7395 N N   . ILE D 1 207 ? -91.623  53.515 78.070  1.00 33.59  ? 1057 ILE D N   1 
ATOM   7396 C CA  . ILE D 1 207 ? -91.241  53.380 79.473  1.00 32.91  ? 1057 ILE D CA  1 
ATOM   7397 C C   . ILE D 1 207 ? -91.320  54.751 80.126  1.00 38.08  ? 1057 ILE D C   1 
ATOM   7398 O O   . ILE D 1 207 ? -90.702  55.707 79.642  1.00 36.16  ? 1057 ILE D O   1 
ATOM   7399 C CB  . ILE D 1 207 ? -89.823  52.799 79.645  1.00 29.80  ? 1057 ILE D CB  1 
ATOM   7400 C CG1 . ILE D 1 207 ? -89.691  51.442 78.949  1.00 31.09  ? 1057 ILE D CG1 1 
ATOM   7401 C CG2 . ILE D 1 207 ? -89.477  52.685 81.130  1.00 32.11  ? 1057 ILE D CG2 1 
ATOM   7402 C CD1 . ILE D 1 207 ? -88.258  50.936 78.861  1.00 34.79  ? 1057 ILE D CD1 1 
ATOM   7403 N N   . ASP D 1 208 ? -92.064  54.846 81.226  1.00 33.87  ? 1058 ASP D N   1 
ATOM   7404 C CA  . ASP D 1 208 ? -92.110  56.065 82.033  1.00 34.09  ? 1058 ASP D CA  1 
ATOM   7405 C C   . ASP D 1 208 ? -91.795  55.710 83.481  1.00 38.73  ? 1058 ASP D C   1 
ATOM   7406 O O   . ASP D 1 208 ? -92.664  55.180 84.195  1.00 34.31  ? 1058 ASP D O   1 
ATOM   7407 C CB  . ASP D 1 208 ? -93.458  56.767 81.941  1.00 35.22  ? 1058 ASP D CB  1 
ATOM   7408 C CG  . ASP D 1 208 ? -93.512  58.017 82.800  1.00 43.44  ? 1058 ASP D CG  1 
ATOM   7409 O OD1 . ASP D 1 208 ? -92.439  58.617 83.025  1.00 47.57  ? 1058 ASP D OD1 1 
ATOM   7410 O OD2 . ASP D 1 208 ? -94.611  58.400 83.252  1.00 46.93  ? 1058 ASP D OD2 1 
ATOM   7411 N N   . PRO D 1 209 ? -90.572  55.972 83.946  1.00 41.36  ? 1059 PRO D N   1 
ATOM   7412 C CA  . PRO D 1 209 ? -90.223  55.606 85.333  1.00 37.07  ? 1059 PRO D CA  1 
ATOM   7413 C C   . PRO D 1 209 ? -91.095  56.269 86.402  1.00 39.55  ? 1059 PRO D C   1 
ATOM   7414 O O   . PRO D 1 209 ? -91.322  55.664 87.462  1.00 40.69  ? 1059 PRO D O   1 
ATOM   7415 C CB  . PRO D 1 209 ? -88.747  56.028 85.444  1.00 37.20  ? 1059 PRO D CB  1 
ATOM   7416 C CG  . PRO D 1 209 ? -88.452  56.845 84.205  1.00 45.77  ? 1059 PRO D CG  1 
ATOM   7417 C CD  . PRO D 1 209 ? -89.390  56.359 83.158  1.00 35.34  ? 1059 PRO D CD  1 
ATOM   7418 N N   . ALA D 1 210 ? -91.617  57.474 86.154  1.00 38.10  ? 1060 ALA D N   1 
ATOM   7419 C CA  . ALA D 1 210 ? -92.473  58.136 87.141  1.00 45.87  ? 1060 ALA D CA  1 
ATOM   7420 C C   . ALA D 1 210 ? -93.783  57.364 87.343  1.00 42.13  ? 1060 ALA D C   1 
ATOM   7421 O O   . ALA D 1 210 ? -94.215  57.096 88.485  1.00 49.47  ? 1060 ALA D O   1 
ATOM   7422 C CB  . ALA D 1 210 ? -92.736  59.580 86.704  1.00 45.45  ? 1060 ALA D CB  1 
ATOM   7423 N N   . THR D 1 211 ? -94.429  56.989 86.236  1.00 39.74  ? 1061 THR D N   1 
ATOM   7424 C CA  . THR D 1 211 ? -95.613  56.144 86.325  1.00 39.46  ? 1061 THR D CA  1 
ATOM   7425 C C   . THR D 1 211 ? -95.280  54.798 86.957  1.00 43.89  ? 1061 THR D C   1 
ATOM   7426 O O   . THR D 1 211 ? -96.061  54.268 87.760  1.00 41.43  ? 1061 THR D O   1 
ATOM   7427 C CB  . THR D 1 211 ? -96.219  55.945 84.937  1.00 43.02  ? 1061 THR D CB  1 
ATOM   7428 O OG1 . THR D 1 211 ? -96.633  57.212 84.413  1.00 40.47  ? 1061 THR D OG1 1 
ATOM   7429 C CG2 . THR D 1 211 ? -97.421  55.013 85.009  1.00 45.10  ? 1061 THR D CG2 1 
ATOM   7430 N N   . HIS D 1 212 ? -94.118  54.236 86.610  1.00 35.03  ? 1062 HIS D N   1 
ATOM   7431 C CA  . HIS D 1 212 ? -93.685  52.975 87.201  1.00 39.93  ? 1062 HIS D CA  1 
ATOM   7432 C C   . HIS D 1 212 ? -93.711  53.052 88.718  1.00 38.98  ? 1062 HIS D C   1 
ATOM   7433 O O   . HIS D 1 212 ? -94.243  52.161 89.390  1.00 41.72  ? 1062 HIS D O   1 
ATOM   7434 C CB  . HIS D 1 212 ? -92.276  52.627 86.718  1.00 33.34  ? 1062 HIS D CB  1 
ATOM   7435 C CG  . HIS D 1 212 ? -91.878  51.208 86.979  1.00 33.18  ? 1062 HIS D CG  1 
ATOM   7436 N ND1 . HIS D 1 212 ? -92.480  50.137 86.356  1.00 35.18  ? 1062 HIS D ND1 1 
ATOM   7437 C CD2 . HIS D 1 212 ? -90.947  50.685 87.811  1.00 31.76  ? 1062 HIS D CD2 1 
ATOM   7438 C CE1 . HIS D 1 212 ? -91.929  49.015 86.783  1.00 35.64  ? 1062 HIS D CE1 1 
ATOM   7439 N NE2 . HIS D 1 212 ? -90.997  49.320 87.668  1.00 32.72  ? 1062 HIS D NE2 1 
ATOM   7440 N N   . ARG D 1 213 ? -93.155  54.132 89.274  1.00 38.69  ? 1063 ARG D N   1 
ATOM   7441 C CA  A ARG D 1 213 ? -93.116  54.257 90.726  0.45 43.52  ? 1063 ARG D CA  1 
ATOM   7442 C CA  B ARG D 1 213 ? -93.119  54.279 90.727  0.55 43.53  ? 1063 ARG D CA  1 
ATOM   7443 C C   . ARG D 1 213 ? -94.521  54.332 91.310  1.00 46.80  ? 1063 ARG D C   1 
ATOM   7444 O O   . ARG D 1 213 ? -94.784  53.768 92.380  1.00 44.43  ? 1063 ARG D O   1 
ATOM   7445 C CB  A ARG D 1 213 ? -92.297  55.484 91.133  0.45 44.28  ? 1063 ARG D CB  1 
ATOM   7446 C CB  B ARG D 1 213 ? -92.348  55.539 91.108  0.55 44.27  ? 1063 ARG D CB  1 
ATOM   7447 C CG  A ARG D 1 213 ? -90.782  55.256 91.208  0.45 45.88  ? 1063 ARG D CG  1 
ATOM   7448 C CG  B ARG D 1 213 ? -90.890  55.495 90.730  0.55 45.73  ? 1063 ARG D CG  1 
ATOM   7449 C CD  A ARG D 1 213 ? -90.373  53.911 90.623  0.45 43.64  ? 1063 ARG D CD  1 
ATOM   7450 C CD  B ARG D 1 213 ? -90.235  56.857 90.849  0.55 47.28  ? 1063 ARG D CD  1 
ATOM   7451 N NE  A ARG D 1 213 ? -88.959  53.609 90.810  0.45 47.86  ? 1063 ARG D NE  1 
ATOM   7452 N NE  B ARG D 1 213 ? -88.939  56.851 90.185  0.55 48.28  ? 1063 ARG D NE  1 
ATOM   7453 C CZ  A ARG D 1 213 ? -88.092  53.473 89.817  0.45 47.19  ? 1063 ARG D CZ  1 
ATOM   7454 C CZ  B ARG D 1 213 ? -88.616  57.626 89.160  0.55 45.07  ? 1063 ARG D CZ  1 
ATOM   7455 N NH1 A ARG D 1 213 ? -88.452  53.659 88.558  0.45 43.34  ? 1063 ARG D NH1 1 
ATOM   7456 N NH1 B ARG D 1 213 ? -89.446  58.548 88.700  0.55 44.65  ? 1063 ARG D NH1 1 
ATOM   7457 N NH2 A ARG D 1 213 ? -86.834  53.139 90.093  0.45 45.25  ? 1063 ARG D NH2 1 
ATOM   7458 N NH2 B ARG D 1 213 ? -87.430  57.470 88.580  0.55 47.74  ? 1063 ARG D NH2 1 
ATOM   7459 N N   . GLN D 1 214 ? -95.438  55.023 90.624  1.00 45.29  ? 1064 GLN D N   1 
ATOM   7460 C CA  . GLN D 1 214 ? -96.806  55.093 91.153  1.00 45.59  ? 1064 GLN D CA  1 
ATOM   7461 C C   . GLN D 1 214 ? -97.580  53.776 91.034  1.00 47.75  ? 1064 GLN D C   1 
ATOM   7462 O O   . GLN D 1 214 ? -98.572  53.592 91.751  1.00 47.65  ? 1064 GLN D O   1 
ATOM   7463 C CB  . GLN D 1 214 ? -97.571  56.236 90.504  1.00 49.37  ? 1064 GLN D CB  1 
ATOM   7464 C CG  . GLN D 1 214 ? -96.748  57.498 90.443  1.00 53.01  ? 1064 GLN D CG  1 
ATOM   7465 C CD  . GLN D 1 214 ? -97.084  58.463 91.560  1.00 69.70  ? 1064 GLN D CD  1 
ATOM   7466 O OE1 . GLN D 1 214 ? -97.216  58.067 92.720  1.00 74.64  ? 1064 GLN D OE1 1 
ATOM   7467 N NE2 . GLN D 1 214 ? -97.228  59.736 91.218  1.00 70.83  ? 1064 GLN D NE2 1 
ATOM   7468 N N   . LYS D 1 215 ? -97.227  52.907 90.087  1.00 38.00  ? 1065 LYS D N   1 
ATOM   7469 C CA  . LYS D 1 215 ? -97.952  51.652 89.907  1.00 39.17  ? 1065 LYS D CA  1 
ATOM   7470 C C   . LYS D 1 215 ? -97.463  50.533 90.820  1.00 43.91  ? 1065 LYS D C   1 
ATOM   7471 O O   . LYS D 1 215 ? -98.143  49.506 90.941  1.00 42.93  ? 1065 LYS D O   1 
ATOM   7472 C CB  . LYS D 1 215 ? -97.866  51.190 88.452  1.00 37.28  ? 1065 LYS D CB  1 
ATOM   7473 C CG  . LYS D 1 215 ? -98.739  52.013 87.532  1.00 41.79  ? 1065 LYS D CG  1 
ATOM   7474 C CD  . LYS D 1 215 ? -100.015 51.266 87.190  1.00 45.27  ? 1065 LYS D CD  1 
ATOM   7475 C CE  . LYS D 1 215 ? -100.601 51.736 85.873  1.00 57.35  ? 1065 LYS D CE  1 
ATOM   7476 N NZ  . LYS D 1 215 ? -102.088 51.644 85.877  1.00 57.97  ? 1065 LYS D NZ  1 
ATOM   7477 N N   . LEU D 1 216 ? -96.285  50.681 91.413  1.00 36.83  ? 1066 LEU D N   1 
ATOM   7478 C CA  . LEU D 1 216 ? -95.775  49.689 92.345  1.00 37.93  ? 1066 LEU D CA  1 
ATOM   7479 C C   . LEU D 1 216 ? -96.598  49.681 93.631  1.00 34.43  ? 1066 LEU D C   1 
ATOM   7480 O O   . LEU D 1 216 ? -97.060  50.722 94.107  1.00 39.79  ? 1066 LEU D O   1 
ATOM   7481 C CB  . LEU D 1 216 ? -94.312  49.994 92.661  1.00 38.27  ? 1066 LEU D CB  1 
ATOM   7482 C CG  . LEU D 1 216 ? -93.338  49.756 91.502  1.00 40.74  ? 1066 LEU D CG  1 
ATOM   7483 C CD1 . LEU D 1 216 ? -91.924  50.178 91.879  1.00 38.31  ? 1066 LEU D CD1 1 
ATOM   7484 C CD2 . LEU D 1 216 ? -93.368  48.311 91.027  1.00 33.21  ? 1066 LEU D CD2 1 
ATOM   7485 N N   . TYR D 1 217 ? -96.761  48.493 94.212  1.00 40.04  ? 1067 TYR D N   1 
ATOM   7486 C CA  . TYR D 1 217 ? -97.356  48.367 95.535  1.00 38.41  ? 1067 TYR D CA  1 
ATOM   7487 C C   . TYR D 1 217 ? -96.653  47.242 96.281  1.00 43.58  ? 1067 TYR D C   1 
ATOM   7488 O O   . TYR D 1 217 ? -95.937  46.427 95.693  1.00 38.73  ? 1067 TYR D O   1 
ATOM   7489 C CB  . TYR D 1 217 ? -98.876  48.165 95.472  1.00 38.52  ? 1067 TYR D CB  1 
ATOM   7490 C CG  . TYR D 1 217 ? -99.363  46.910 94.802  1.00 41.75  ? 1067 TYR D CG  1 
ATOM   7491 C CD1 . TYR D 1 217 ? -99.544  46.865 93.427  1.00 38.91  ? 1067 TYR D CD1 1 
ATOM   7492 C CD2 . TYR D 1 217 ? -99.694  45.788 95.549  1.00 39.66  ? 1067 TYR D CD2 1 
ATOM   7493 C CE1 . TYR D 1 217 ? -100.008 45.743 92.820  1.00 35.64  ? 1067 TYR D CE1 1 
ATOM   7494 C CE2 . TYR D 1 217 ? -100.160 44.659 94.945  1.00 39.81  ? 1067 TYR D CE2 1 
ATOM   7495 C CZ  . TYR D 1 217 ? -100.312 44.649 93.581  1.00 42.67  ? 1067 TYR D CZ  1 
ATOM   7496 O OH  . TYR D 1 217 ? -100.778 43.539 92.953  1.00 42.32  ? 1067 TYR D OH  1 
ATOM   7497 N N   . THR D 1 218 ? -96.868  47.202 97.593  1.00 39.74  ? 1068 THR D N   1 
ATOM   7498 C CA  . THR D 1 218 ? -96.066  46.396 98.501  1.00 38.51  ? 1068 THR D CA  1 
ATOM   7499 C C   . THR D 1 218 ? -96.882  45.251 99.091  1.00 41.84  ? 1068 THR D C   1 
ATOM   7500 O O   . THR D 1 218 ? -98.056  45.423 99.434  1.00 39.12  ? 1068 THR D O   1 
ATOM   7501 C CB  . THR D 1 218 ? -95.506  47.279 99.621  1.00 43.78  ? 1068 THR D CB  1 
ATOM   7502 O OG1 . THR D 1 218 ? -94.776  48.368 99.042  1.00 43.62  ? 1068 THR D OG1 1 
ATOM   7503 C CG2 . THR D 1 218 ? -94.581  46.488 100.526 1.00 42.15  ? 1068 THR D CG2 1 
ATOM   7504 N N   . LEU D 1 219 ? -96.265  44.070 99.155  1.00 39.48  ? 1069 LEU D N   1 
ATOM   7505 C CA  . LEU D 1 219 ? -96.852  42.890 99.771  1.00 42.30  ? 1069 LEU D CA  1 
ATOM   7506 C C   . LEU D 1 219 ? -96.497  42.810 101.258 1.00 43.01  ? 1069 LEU D C   1 
ATOM   7507 O O   . LEU D 1 219 ? -95.744  43.625 101.795 1.00 41.00  ? 1069 LEU D O   1 
ATOM   7508 C CB  . LEU D 1 219 ? -96.459  41.624 99.018  1.00 42.74  ? 1069 LEU D CB  1 
ATOM   7509 C CG  . LEU D 1 219 ? -96.839  41.647 97.534  1.00 41.24  ? 1069 LEU D CG  1 
ATOM   7510 C CD1 . LEU D 1 219 ? -96.397  40.356 96.859  1.00 44.36  ? 1069 LEU D CD1 1 
ATOM   7511 C CD2 . LEU D 1 219 ? -98.320  41.947 97.289  1.00 38.05  ? 1069 LEU D CD2 1 
ATOM   7512 N N   . GLN D 1 220 ? -97.081  41.820 101.937 1.00 41.81  ? 1070 GLN D N   1 
ATOM   7513 C CA  . GLN D 1 220 ? -96.909  41.693 103.382 1.00 44.40  ? 1070 GLN D CA  1 
ATOM   7514 C C   . GLN D 1 220 ? -95.445  41.490 103.775 1.00 45.67  ? 1070 GLN D C   1 
ATOM   7515 O O   . GLN D 1 220 ? -95.002  42.010 104.806 1.00 50.12  ? 1070 GLN D O   1 
ATOM   7516 C CB  . GLN D 1 220 ? -97.799  40.567 103.909 1.00 48.61  ? 1070 GLN D CB  1 
ATOM   7517 C CG  . GLN D 1 220 ? -98.212  40.778 105.354 1.00 49.64  ? 1070 GLN D CG  1 
ATOM   7518 C CD  . GLN D 1 220 ? -98.852  39.557 105.973 1.00 51.15  ? 1070 GLN D CD  1 
ATOM   7519 O OE1 . GLN D 1 220 ? -99.707  38.910 105.366 1.00 50.67  ? 1070 GLN D OE1 1 
ATOM   7520 N NE2 . GLN D 1 220 ? -98.463  39.252 107.203 1.00 49.66  ? 1070 GLN D NE2 1 
ATOM   7521 N N   . ASP D 1 221 ? -94.693  40.697 103.005 1.00 46.27  ? 1071 ASP D N   1 
ATOM   7522 C CA  . ASP D 1 221 ? -93.272  40.479 103.274 1.00 50.93  ? 1071 ASP D CA  1 
ATOM   7523 C C   . ASP D 1 221 ? -92.368  41.590 102.730 1.00 51.19  ? 1071 ASP D C   1 
ATOM   7524 O O   . ASP D 1 221 ? -91.146  41.396 102.680 1.00 53.80  ? 1071 ASP D O   1 
ATOM   7525 C CB  . ASP D 1 221 ? -92.835  39.117 102.719 1.00 51.54  ? 1071 ASP D CB  1 
ATOM   7526 C CG  . ASP D 1 221 ? -92.724  39.093 101.197 1.00 56.50  ? 1071 ASP D CG  1 
ATOM   7527 O OD1 . ASP D 1 221 ? -93.020  40.108 100.531 1.00 54.59  ? 1071 ASP D OD1 1 
ATOM   7528 O OD2 . ASP D 1 221 ? -92.342  38.033 100.658 1.00 58.94  ? 1071 ASP D OD2 1 
ATOM   7529 N N   . LYS D 1 222 ? -92.939  42.736 102.358 1.00 48.73  ? 1072 LYS D N   1 
ATOM   7530 C CA  . LYS D 1 222 ? -92.290  43.962 101.881 1.00 48.80  ? 1072 LYS D CA  1 
ATOM   7531 C C   . LYS D 1 222 ? -91.789  43.908 100.435 1.00 42.69  ? 1072 LYS D C   1 
ATOM   7532 O O   . LYS D 1 222 ? -91.228  44.910 99.966  1.00 47.46  ? 1072 LYS D O   1 
ATOM   7533 C CB  . LYS D 1 222 ? -91.100  44.353 102.773 1.00 49.13  ? 1072 LYS D CB  1 
ATOM   7534 C CG  . LYS D 1 222 ? -91.489  44.879 104.148 1.00 55.88  ? 1072 LYS D CG  1 
ATOM   7535 C CD  . LYS D 1 222 ? -92.944  45.309 104.203 1.00 46.76  ? 1072 LYS D CD  1 
ATOM   7536 C CE  . LYS D 1 222 ? -93.203  46.232 105.375 1.00 61.49  ? 1072 LYS D CE  1 
ATOM   7537 N NZ  . LYS D 1 222 ? -94.479  45.875 106.062 1.00 58.05  ? 1072 LYS D NZ  1 
ATOM   7538 N N   . ALA D 1 223 ? -92.011  42.823 99.697  1.00 44.44  ? 1073 ALA D N   1 
ATOM   7539 C CA  . ALA D 1 223 ? -91.682  42.811 98.277  1.00 43.60  ? 1073 ALA D CA  1 
ATOM   7540 C C   . ALA D 1 223 ? -92.575  43.780 97.509  1.00 44.32  ? 1073 ALA D C   1 
ATOM   7541 O O   . ALA D 1 223 ? -93.731  44.009 97.866  1.00 39.43  ? 1073 ALA D O   1 
ATOM   7542 C CB  . ALA D 1 223 ? -91.830  41.399 97.709  1.00 45.30  ? 1073 ALA D CB  1 
ATOM   7543 N N   . GLN D 1 224 ? -92.009  44.405 96.482  1.00 40.96  ? 1074 GLN D N   1 
ATOM   7544 C CA  . GLN D 1 224 ? -92.785  45.262 95.597  1.00 38.33  ? 1074 GLN D CA  1 
ATOM   7545 C C   . GLN D 1 224 ? -93.174  44.517 94.334  1.00 37.31  ? 1074 GLN D C   1 
ATOM   7546 O O   . GLN D 1 224 ? -92.441  43.657 93.861  1.00 36.52  ? 1074 GLN D O   1 
ATOM   7547 C CB  . GLN D 1 224 ? -92.037  46.539 95.227  1.00 41.12  ? 1074 GLN D CB  1 
ATOM   7548 C CG  . GLN D 1 224 ? -91.428  47.259 96.398  1.00 47.71  ? 1074 GLN D CG  1 
ATOM   7549 C CD  . GLN D 1 224 ? -90.768  48.548 95.976  1.00 53.60  ? 1074 GLN D CD  1 
ATOM   7550 O OE1 . GLN D 1 224 ? -89.600  48.570 95.595  1.00 58.80  ? 1074 GLN D OE1 1 
ATOM   7551 N NE2 . GLN D 1 224 ? -91.528  49.637 96.021  1.00 57.74  ? 1074 GLN D NE2 1 
ATOM   7552 N N   . VAL D 1 225 ? -94.363  44.823 93.816  1.00 39.31  ? 1075 VAL D N   1 
ATOM   7553 C CA  . VAL D 1 225 ? -94.908  44.145 92.648  1.00 37.57  ? 1075 VAL D CA  1 
ATOM   7554 C C   . VAL D 1 225 ? -95.668  45.159 91.810  1.00 34.09  ? 1075 VAL D C   1 
ATOM   7555 O O   . VAL D 1 225 ? -95.982  46.263 92.255  1.00 34.47  ? 1075 VAL D O   1 
ATOM   7556 C CB  . VAL D 1 225 ? -95.851  42.978 93.007  1.00 41.08  ? 1075 VAL D CB  1 
ATOM   7557 C CG1 . VAL D 1 225 ? -95.079  41.862 93.647  1.00 43.02  ? 1075 VAL D CG1 1 
ATOM   7558 C CG2 . VAL D 1 225 ? -96.978  43.455 93.900  1.00 41.25  ? 1075 VAL D CG2 1 
ATOM   7559 N N   . ALA D 1 226 ? -95.924  44.778 90.568  1.00 35.86  ? 1076 ALA D N   1 
ATOM   7560 C CA  . ALA D 1 226 ? -96.809  45.497 89.673  1.00 37.29  ? 1076 ALA D CA  1 
ATOM   7561 C C   . ALA D 1 226 ? -97.722  44.500 88.978  1.00 33.01  ? 1076 ALA D C   1 
ATOM   7562 O O   . ALA D 1 226 ? -97.329  43.365 88.683  1.00 39.23  ? 1076 ALA D O   1 
ATOM   7563 C CB  . ALA D 1 226 ? -96.038  46.317 88.636  1.00 41.14  ? 1076 ALA D CB  1 
ATOM   7564 N N   . ASP D 1 227 ? -98.953  44.928 88.734  1.00 40.65  ? 1077 ASP D N   1 
ATOM   7565 C CA  . ASP D 1 227 ? -99.895  44.107 87.996  1.00 40.30  ? 1077 ASP D CA  1 
ATOM   7566 C C   . ASP D 1 227 ? -99.540  44.131 86.513  1.00 37.72  ? 1077 ASP D C   1 
ATOM   7567 O O   . ASP D 1 227 ? -99.193  45.181 85.961  1.00 42.77  ? 1077 ASP D O   1 
ATOM   7568 C CB  . ASP D 1 227 ? -101.310 44.637 88.217  1.00 36.70  ? 1077 ASP D CB  1 
ATOM   7569 C CG  . ASP D 1 227 ? -101.838 44.322 89.598  1.00 46.40  ? 1077 ASP D CG  1 
ATOM   7570 O OD1 . ASP D 1 227 ? -101.269 43.470 90.263  1.00 42.82  ? 1077 ASP D OD1 1 
ATOM   7571 O OD2 . ASP D 1 227 ? -102.790 44.976 90.053  1.00 46.72  ? 1077 ASP D OD2 1 
ATOM   7572 N N   . VAL D 1 228 ? -99.638  42.969 85.862  1.00 37.59  ? 1078 VAL D N   1 
ATOM   7573 C CA  . VAL D 1 228 ? -99.367  42.848 84.433  1.00 37.19  ? 1078 VAL D CA  1 
ATOM   7574 C C   . VAL D 1 228 ? -100.642 42.388 83.742  1.00 46.35  ? 1078 VAL D C   1 
ATOM   7575 O O   . VAL D 1 228 ? -101.398 41.573 84.287  1.00 42.27  ? 1078 VAL D O   1 
ATOM   7576 C CB  . VAL D 1 228 ? -98.192  41.888 84.131  1.00 37.08  ? 1078 VAL D CB  1 
ATOM   7577 C CG1 . VAL D 1 228 ? -98.459  40.507 84.689  1.00 41.39  ? 1078 VAL D CG1 1 
ATOM   7578 C CG2 . VAL D 1 228 ? -97.912  41.813 82.627  1.00 37.07  ? 1078 VAL D CG2 1 
ATOM   7579 N N   . VAL D 1 229 ? -100.881 42.942 82.551  1.00 39.59  ? 1079 VAL D N   1 
ATOM   7580 C CA  . VAL D 1 229 ? -102.009 42.602 81.693  1.00 43.55  ? 1079 VAL D CA  1 
ATOM   7581 C C   . VAL D 1 229 ? -101.491 42.316 80.288  1.00 46.78  ? 1079 VAL D C   1 
ATOM   7582 O O   . VAL D 1 229 ? -100.660 43.068 79.764  1.00 43.87  ? 1079 VAL D O   1 
ATOM   7583 C CB  . VAL D 1 229 ? -103.040 43.748 81.662  1.00 44.39  ? 1079 VAL D CB  1 
ATOM   7584 C CG1 . VAL D 1 229 ? -104.082 43.525 80.575  1.00 53.69  ? 1079 VAL D CG1 1 
ATOM   7585 C CG2 . VAL D 1 229 ? -103.688 43.924 83.029  1.00 49.74  ? 1079 VAL D CG2 1 
ATOM   7586 N N   . VAL D 1 230 ? -102.014 41.260 79.675  1.00 44.97  ? 1080 VAL D N   1 
ATOM   7587 C CA  . VAL D 1 230 ? -101.699 40.929 78.261  1.00 41.86  ? 1080 VAL D CA  1 
ATOM   7588 C C   . VAL D 1 230 ? -103.005 40.935 77.445  1.00 55.19  ? 1080 VAL D C   1 
ATOM   7589 O O   . VAL D 1 230 ? -103.868 40.110 77.748  1.00 47.33  ? 1080 VAL D O   1 
ATOM   7590 C CB  . VAL D 1 230 ? -100.972 39.581 78.169  1.00 43.91  ? 1080 VAL D CB  1 
ATOM   7591 C CG1 . VAL D 1 230 ? -100.617 39.234 76.736  1.00 51.95  ? 1080 VAL D CG1 1 
ATOM   7592 C CG2 . VAL D 1 230 ? -99.745  39.537 79.059  1.00 46.70  ? 1080 VAL D CG2 1 
ATOM   7593 N N   . SER D 1 231 ? -103.149 41.844 76.478  1.00 47.46  ? 1081 SER D N   1 
ATOM   7594 C CA  . SER D 1 231 ? -104.342 41.951 75.597  1.00 55.65  ? 1081 SER D CA  1 
ATOM   7595 C C   . SER D 1 231 ? -103.986 41.527 74.180  1.00 61.59  ? 1081 SER D C   1 
ATOM   7596 O O   . SER D 1 231 ? -103.121 42.171 73.580  1.00 60.06  ? 1081 SER D O   1 
ATOM   7597 C CB  . SER D 1 231 ? -104.818 43.363 75.543  1.00 59.24  ? 1081 SER D CB  1 
ATOM   7598 O OG  . SER D 1 231 ? -105.471 43.636 74.313  1.00 61.00  ? 1081 SER D OG  1 
ATOM   7599 N N   . ARG D 1 232 ? -104.645 40.519 73.644  1.00 64.86  ? 1082 ARG D N   1 
ATOM   7600 C CA  . ARG D 1 232 ? -104.401 40.134 72.228  1.00 70.08  ? 1082 ARG D CA  1 
ATOM   7601 C C   . ARG D 1 232 ? -105.234 41.013 71.294  1.00 67.21  ? 1082 ARG D C   1 
ATOM   7602 O O   . ARG D 1 232 ? -104.862 41.167 70.130  1.00 69.28  ? 1082 ARG D O   1 
ATOM   7603 C CB  . ARG D 1 232 ? -104.708 38.654 72.029  1.00 73.58  ? 1082 ARG D CB  1 
ATOM   7604 C CG  . ARG D 1 232 ? -103.800 37.751 72.854  1.00 78.95  ? 1082 ARG D CG  1 
ATOM   7605 C CD  . ARG D 1 232 ? -104.237 36.305 72.990  1.00 89.89  ? 1082 ARG D CD  1 
ATOM   7606 N NE  . ARG D 1 232 ? -105.371 36.116 73.886  1.00 96.76  ? 1082 ARG D NE  1 
ATOM   7607 C CZ  . ARG D 1 232 ? -106.488 35.474 73.564  1.00 99.70  ? 1082 ARG D CZ  1 
ATOM   7608 N NH1 . ARG D 1 232 ? -106.527 34.718 72.481  1.00 99.85  ? 1082 ARG D NH1 1 
ATOM   7609 N NH2 . ARG D 1 232 ? -107.562 35.586 74.325  1.00 94.91  ? 1082 ARG D NH2 1 
ATOM   7610 N N   . TRP D 1 233 ? -106.329 41.572 71.794  1.00 68.67  ? 1083 TRP D N   1 
ATOM   7611 C CA  . TRP D 1 233 ? -107.085 42.497 70.921  1.00 69.30  ? 1083 TRP D CA  1 
ATOM   7612 C C   . TRP D 1 233 ? -106.127 43.615 70.531  1.00 70.16  ? 1083 TRP D C   1 
ATOM   7613 O O   . TRP D 1 233 ? -106.356 44.281 69.518  1.00 65.65  ? 1083 TRP D O   1 
ATOM   7614 C CB  . TRP D 1 233 ? -108.343 43.021 71.610  1.00 63.10  ? 1083 TRP D CB  1 
ATOM   7615 C CG  . TRP D 1 233 ? -109.434 42.009 71.720  1.00 63.84  ? 1083 TRP D CG  1 
ATOM   7616 C CD1 . TRP D 1 233 ? -109.529 40.819 71.062  1.00 69.77  ? 1083 TRP D CD1 1 
ATOM   7617 C CD2 . TRP D 1 233 ? -110.573 42.084 72.589  1.00 59.39  ? 1083 TRP D CD2 1 
ATOM   7618 N NE1 . TRP D 1 233 ? -110.665 40.160 71.445  1.00 68.71  ? 1083 TRP D NE1 1 
ATOM   7619 C CE2 . TRP D 1 233 ? -111.324 40.911 72.381  1.00 61.91  ? 1083 TRP D CE2 1 
ATOM   7620 C CE3 . TRP D 1 233 ? -111.034 43.031 73.506  1.00 57.81  ? 1083 TRP D CE3 1 
ATOM   7621 C CZ2 . TRP D 1 233 ? -112.511 40.662 73.063  1.00 63.75  ? 1083 TRP D CZ2 1 
ATOM   7622 C CZ3 . TRP D 1 233 ? -112.206 42.784 74.180  1.00 57.29  ? 1083 TRP D CZ3 1 
ATOM   7623 C CH2 . TRP D 1 233 ? -112.930 41.615 73.960  1.00 57.43  ? 1083 TRP D CH2 1 
ATOM   7624 N N   . LEU D 1 234 ? -105.071 43.790 71.303  1.00 64.16  ? 1084 LEU D N   1 
ATOM   7625 C CA  . LEU D 1 234 ? -104.202 44.922 70.939  1.00 64.05  ? 1084 LEU D CA  1 
ATOM   7626 C C   . LEU D 1 234 ? -102.757 44.437 70.820  1.00 57.67  ? 1084 LEU D C   1 
ATOM   7627 O O   . LEU D 1 234 ? -101.906 45.277 70.562  1.00 63.90  ? 1084 LEU D O   1 
ATOM   7628 C CB  . LEU D 1 234 ? -104.399 46.042 71.962  1.00 58.03  ? 1084 LEU D CB  1 
ATOM   7629 C CG  . LEU D 1 234 ? -105.778 46.694 71.959  1.00 63.39  ? 1084 LEU D CG  1 
ATOM   7630 C CD1 . LEU D 1 234 ? -106.389 46.666 73.350  1.00 62.58  ? 1084 LEU D CD1 1 
ATOM   7631 C CD2 . LEU D 1 234 ? -105.704 48.116 71.430  1.00 60.95  ? 1084 LEU D CD2 1 
ATOM   7632 N N   . ARG D 1 235 ? -102.515 43.139 70.927  1.00 56.04  ? 1085 ARG D N   1 
ATOM   7633 C CA  . ARG D 1 235 ? -101.107 42.660 70.934  1.00 58.21  ? 1085 ARG D CA  1 
ATOM   7634 C C   . ARG D 1 235 ? -100.288 43.594 71.837  1.00 52.91  ? 1085 ARG D C   1 
ATOM   7635 O O   . ARG D 1 235 ? -99.280  44.119 71.376  1.00 42.62  ? 1085 ARG D O   1 
ATOM   7636 C CB  . ARG D 1 235 ? -100.601 42.549 69.498  1.00 54.34  ? 1085 ARG D CB  1 
ATOM   7637 C CG  . ARG D 1 235 ? -101.436 41.613 68.636  1.00 60.39  ? 1085 ARG D CG  1 
ATOM   7638 C CD  . ARG D 1 235 ? -100.894 41.381 67.240  1.00 62.76  ? 1085 ARG D CD  1 
ATOM   7639 N NE  . ARG D 1 235 ? -101.758 40.489 66.480  1.00 64.04  ? 1085 ARG D NE  1 
ATOM   7640 C CZ  . ARG D 1 235 ? -101.505 40.056 65.252  1.00 61.41  ? 1085 ARG D CZ  1 
ATOM   7641 N NH1 . ARG D 1 235 ? -100.315 40.249 64.713  1.00 59.70  ? 1085 ARG D NH1 1 
ATOM   7642 N NH2 . ARG D 1 235 ? -102.441 39.427 64.566  1.00 63.27  ? 1085 ARG D NH2 1 
ATOM   7643 N N   . VAL D 1 236 ? -100.745 43.784 73.074  1.00 50.90  ? 1086 VAL D N   1 
ATOM   7644 C CA  . VAL D 1 236 ? -100.074 44.707 74.023  1.00 41.73  ? 1086 VAL D CA  1 
ATOM   7645 C C   . VAL D 1 236 ? -99.866  44.018 75.370  1.00 48.42  ? 1086 VAL D C   1 
ATOM   7646 O O   . VAL D 1 236 ? -100.708 43.207 75.738  1.00 47.42  ? 1086 VAL D O   1 
ATOM   7647 C CB  . VAL D 1 236 ? -100.860 46.009 74.192  1.00 45.72  ? 1086 VAL D CB  1 
ATOM   7648 C CG1 . VAL D 1 236 ? -100.354 46.834 75.358  1.00 44.12  ? 1086 VAL D CG1 1 
ATOM   7649 C CG2 . VAL D 1 236 ? -100.866 46.830 72.918  1.00 46.82  ? 1086 VAL D CG2 1 
ATOM   7650 N N   . THR D 1 237 ? -98.742  44.301 76.025  1.00 42.08  ? 1087 THR D N   1 
ATOM   7651 C CA  . THR D 1 237 ? -98.450  43.788 77.386  1.00 38.57  ? 1087 THR D CA  1 
ATOM   7652 C C   . THR D 1 237 ? -98.068  45.012 78.220  1.00 40.61  ? 1087 THR D C   1 
ATOM   7653 O O   . THR D 1 237 ? -97.175  45.734 77.799  1.00 37.53  ? 1087 THR D O   1 
ATOM   7654 C CB  . THR D 1 237 ? -97.418  42.656 77.374  1.00 35.14  ? 1087 THR D CB  1 
ATOM   7655 O OG1 . THR D 1 237 ? -97.902  41.547 76.623  1.00 40.13  ? 1087 THR D OG1 1 
ATOM   7656 C CG2 . THR D 1 237 ? -97.050  42.200 78.768  1.00 40.66  ? 1087 THR D CG2 1 
ATOM   7657 N N   . VAL D 1 238 ? -98.768  45.249 79.318  1.00 31.96  ? 1088 VAL D N   1 
ATOM   7658 C CA  . VAL D 1 238 ? -98.555  46.430 80.144  1.00 32.42  ? 1088 VAL D CA  1 
ATOM   7659 C C   . VAL D 1 238 ? -98.326  45.988 81.574  1.00 41.45  ? 1088 VAL D C   1 
ATOM   7660 O O   . VAL D 1 238 ? -99.022  45.103 82.086  1.00 39.97  ? 1088 VAL D O   1 
ATOM   7661 C CB  . VAL D 1 238 ? -99.731  47.427 80.090  1.00 39.43  ? 1088 VAL D CB  1 
ATOM   7662 C CG1 . VAL D 1 238 ? -99.276  48.803 80.553  1.00 40.09  ? 1088 VAL D CG1 1 
ATOM   7663 C CG2 . VAL D 1 238 ? -100.268 47.523 78.704  1.00 49.00  ? 1088 VAL D CG2 1 
ATOM   7664 N N   . ALA D 1 239 ? -97.339  46.606 82.214  1.00 38.11  ? 1089 ALA D N   1 
ATOM   7665 C CA  . ALA D 1 239 ? -97.060  46.325 83.614  1.00 32.15  ? 1089 ALA D CA  1 
ATOM   7666 C C   . ALA D 1 239 ? -96.235  47.480 84.152  1.00 40.61  ? 1089 ALA D C   1 
ATOM   7667 O O   . ALA D 1 239 ? -95.240  47.872 83.531  1.00 37.85  ? 1089 ALA D O   1 
ATOM   7668 C CB  . ALA D 1 239 ? -96.320  44.991 83.779  1.00 33.48  ? 1089 ALA D CB  1 
ATOM   7669 N N   . GLY D 1 240 ? -96.640  48.008 85.303  1.00 36.82  ? 1090 GLY D N   1 
ATOM   7670 C CA  . GLY D 1 240 ? -95.960  49.171 85.851  1.00 39.73  ? 1090 GLY D CA  1 
ATOM   7671 C C   . GLY D 1 240 ? -95.955  50.325 84.866  1.00 43.33  ? 1090 GLY D C   1 
ATOM   7672 O O   . GLY D 1 240 ? -96.990  50.708 84.310  1.00 37.13  ? 1090 GLY D O   1 
ATOM   7673 N N   . GLY D 1 241 ? -94.778  50.909 84.662  1.00 36.42  ? 1091 GLY D N   1 
ATOM   7674 C CA  . GLY D 1 241 ? -94.635  51.961 83.679  1.00 33.79  ? 1091 GLY D CA  1 
ATOM   7675 C C   . GLY D 1 241 ? -94.015  51.476 82.386  1.00 34.90  ? 1091 GLY D C   1 
ATOM   7676 O O   . GLY D 1 241 ? -93.302  52.232 81.718  1.00 33.23  ? 1091 GLY D O   1 
ATOM   7677 N N   . VAL D 1 242 ? -94.298  50.229 82.005  1.00 33.54  ? 1092 VAL D N   1 
ATOM   7678 C CA  . VAL D 1 242 ? -93.789  49.654 80.764  1.00 34.53  ? 1092 VAL D CA  1 
ATOM   7679 C C   . VAL D 1 242 ? -94.967  49.204 79.911  1.00 41.04  ? 1092 VAL D C   1 
ATOM   7680 O O   . VAL D 1 242 ? -95.856  48.483 80.388  1.00 37.70  ? 1092 VAL D O   1 
ATOM   7681 C CB  . VAL D 1 242 ? -92.824  48.483 81.024  1.00 35.71  ? 1092 VAL D CB  1 
ATOM   7682 C CG1 . VAL D 1 242 ? -92.292  47.940 79.705  1.00 33.29  ? 1092 VAL D CG1 1 
ATOM   7683 C CG2 . VAL D 1 242 ? -91.677  48.934 81.910  1.00 32.71  ? 1092 VAL D CG2 1 
ATOM   7684 N N   . HIS D 1 243 ? -94.953  49.623 78.644  1.00 30.84  ? 1093 HIS D N   1 
ATOM   7685 C CA  . HIS D 1 243 ? -95.995  49.316 77.673  1.00 30.83  ? 1093 HIS D CA  1 
ATOM   7686 C C   . HIS D 1 243 ? -95.322  48.744 76.433  1.00 36.17  ? 1093 HIS D C   1 
ATOM   7687 O O   . HIS D 1 243 ? -94.548  49.444 75.772  1.00 33.99  ? 1093 HIS D O   1 
ATOM   7688 C CB  . HIS D 1 243 ? -96.789  50.586 77.345  1.00 34.96  ? 1093 HIS D CB  1 
ATOM   7689 C CG  . HIS D 1 243 ? -97.942  50.371 76.418  1.00 41.16  ? 1093 HIS D CG  1 
ATOM   7690 N ND1 . HIS D 1 243 ? -97.793  50.256 75.053  1.00 39.21  ? 1093 HIS D ND1 1 
ATOM   7691 C CD2 . HIS D 1 243 ? -99.270  50.264 76.662  1.00 41.78  ? 1093 HIS D CD2 1 
ATOM   7692 C CE1 . HIS D 1 243 ? -98.979  50.085 74.496  1.00 45.80  ? 1093 HIS D CE1 1 
ATOM   7693 N NE2 . HIS D 1 243 ? -99.892  50.087 75.451  1.00 43.11  ? 1093 HIS D NE2 1 
ATOM   7694 N N   . ILE D 1 244 ? -95.606  47.481 76.123  1.00 33.13  ? 1094 ILE D N   1 
ATOM   7695 C CA  . ILE D 1 244 ? -94.982  46.765 75.015  1.00 34.84  ? 1094 ILE D CA  1 
ATOM   7696 C C   . ILE D 1 244 ? -96.059  46.462 73.980  1.00 44.70  ? 1094 ILE D C   1 
ATOM   7697 O O   . ILE D 1 244 ? -97.035  45.766 74.281  1.00 39.90  ? 1094 ILE D O   1 
ATOM   7698 C CB  . ILE D 1 244 ? -94.304  45.474 75.500  1.00 37.75  ? 1094 ILE D CB  1 
ATOM   7699 C CG1 . ILE D 1 244 ? -93.205  45.788 76.520  1.00 34.34  ? 1094 ILE D CG1 1 
ATOM   7700 C CG2 . ILE D 1 244 ? -93.737  44.689 74.331  1.00 39.85  ? 1094 ILE D CG2 1 
ATOM   7701 C CD1 . ILE D 1 244 ? -92.550  44.554 77.109  1.00 36.61  ? 1094 ILE D CD1 1 
ATOM   7702 N N   . SER D 1 245 ? -95.860  46.934 72.752  1.00 38.69  ? 1095 SER D N   1 
ATOM   7703 C CA  . SER D 1 245 ? -96.832  46.817 71.675  1.00 35.99  ? 1095 SER D CA  1 
ATOM   7704 C C   . SER D 1 245 ? -96.196  46.118 70.485  1.00 42.74  ? 1095 SER D C   1 
ATOM   7705 O O   . SER D 1 245 ? -95.113  46.510 70.031  1.00 37.89  ? 1095 SER D O   1 
ATOM   7706 C CB  . SER D 1 245 ? -97.346  48.192 71.240  1.00 41.24  ? 1095 SER D CB  1 
ATOM   7707 O OG  . SER D 1 245 ? -98.260  48.067 70.164  1.00 50.70  ? 1095 SER D OG  1 
ATOM   7708 N N   . GLY D 1 246 ? -96.879  45.098 69.978  1.00 36.49  ? 1096 GLY D N   1 
ATOM   7709 C CA  . GLY D 1 246 ? -96.472  44.431 68.756  1.00 39.52  ? 1096 GLY D CA  1 
ATOM   7710 C C   . GLY D 1 246 ? -95.263  43.532 68.892  1.00 45.07  ? 1096 GLY D C   1 
ATOM   7711 O O   . GLY D 1 246 ? -94.442  43.464 67.968  1.00 40.06  ? 1096 GLY D O   1 
ATOM   7712 N N   . LEU D 1 247 ? -95.152  42.785 69.981  1.00 41.50  ? 1097 LEU D N   1 
ATOM   7713 C CA  . LEU D 1 247 ? -94.042  41.808 70.099  1.00 41.12  ? 1097 LEU D CA  1 
ATOM   7714 C C   . LEU D 1 247 ? -94.268  40.652 69.137  1.00 51.05  ? 1097 LEU D C   1 
ATOM   7715 O O   . LEU D 1 247 ? -95.368  40.100 69.125  1.00 50.08  ? 1097 LEU D O   1 
ATOM   7716 C CB  . LEU D 1 247 ? -93.934  41.265 71.522  1.00 44.26  ? 1097 LEU D CB  1 
ATOM   7717 C CG  . LEU D 1 247 ? -92.997  40.076 71.699  1.00 51.84  ? 1097 LEU D CG  1 
ATOM   7718 C CD1 . LEU D 1 247 ? -91.560  40.549 71.783  1.00 46.20  ? 1097 LEU D CD1 1 
ATOM   7719 C CD2 . LEU D 1 247 ? -93.374  39.283 72.938  1.00 55.68  ? 1097 LEU D CD2 1 
ATOM   7720 N N   . HIS D 1 248 ? -93.243  40.309 68.376  1.00 40.34  ? 1098 HIS D N   1 
ATOM   7721 C CA  . HIS D 1 248 ? -93.338  39.184 67.428  1.00 47.45  ? 1098 HIS D CA  1 
ATOM   7722 C C   . HIS D 1 248 ? -92.220  38.204 67.748  1.00 50.14  ? 1098 HIS D C   1 
ATOM   7723 O O   . HIS D 1 248 ? -91.063  38.606 67.880  1.00 46.72  ? 1098 HIS D O   1 
ATOM   7724 C CB  . HIS D 1 248 ? -93.327  39.657 65.971  1.00 48.46  ? 1098 HIS D CB  1 
ATOM   7725 C CG  . HIS D 1 248 ? -93.273  38.543 64.987  1.00 57.44  ? 1098 HIS D CG  1 
ATOM   7726 N ND1 . HIS D 1 248 ? -94.320  37.675 64.783  1.00 64.04  ? 1098 HIS D ND1 1 
ATOM   7727 C CD2 . HIS D 1 248 ? -92.313  38.166 64.144  1.00 58.93  ? 1098 HIS D CD2 1 
ATOM   7728 C CE1 . HIS D 1 248 ? -93.984  36.800 63.852  1.00 62.68  ? 1098 HIS D CE1 1 
ATOM   7729 N NE2 . HIS D 1 248 ? -92.769  37.082 63.449  1.00 59.11  ? 1098 HIS D NE2 1 
ATOM   7730 N N   . THR D 1 249 ? -92.586  36.943 67.863  1.00 46.79  ? 1099 THR D N   1 
ATOM   7731 C CA  . THR D 1 249 ? -91.603  35.898 68.174  1.00 40.13  ? 1099 THR D CA  1 
ATOM   7732 C C   . THR D 1 249 ? -91.574  34.907 67.021  1.00 53.11  ? 1099 THR D C   1 
ATOM   7733 O O   . THR D 1 249 ? -92.583  34.753 66.354  1.00 53.52  ? 1099 THR D O   1 
ATOM   7734 C CB  . THR D 1 249 ? -91.940  35.237 69.508  1.00 54.66  ? 1099 THR D CB  1 
ATOM   7735 O OG1 . THR D 1 249 ? -93.220  34.631 69.362  1.00 60.11  ? 1099 THR D OG1 1 
ATOM   7736 C CG2 . THR D 1 249 ? -91.952  36.217 70.659  1.00 44.92  ? 1099 THR D CG2 1 
ATOM   7737 N N   . GLU D 1 250 ? -90.431  34.282 66.817  1.00 52.45  ? 1100 GLU D N   1 
ATOM   7738 C CA  . GLU D 1 250 ? -90.277  33.337 65.699  1.00 55.20  ? 1100 GLU D CA  1 
ATOM   7739 C C   . GLU D 1 250 ? -89.533  32.103 66.192  1.00 60.28  ? 1100 GLU D C   1 
ATOM   7740 O O   . GLU D 1 250 ? -88.870  32.193 67.219  1.00 57.02  ? 1100 GLU D O   1 
ATOM   7741 C CB  . GLU D 1 250 ? -89.542  33.961 64.510  1.00 59.35  ? 1100 GLU D CB  1 
ATOM   7742 C CG  . GLU D 1 250 ? -90.204  35.184 63.915  1.00 56.83  ? 1100 GLU D CG  1 
ATOM   7743 C CD  . GLU D 1 250 ? -89.508  35.665 62.653  1.00 64.67  ? 1100 GLU D CD  1 
ATOM   7744 O OE1 . GLU D 1 250 ? -88.605  34.952 62.177  1.00 66.65  ? 1100 GLU D OE1 1 
ATOM   7745 O OE2 . GLU D 1 250 ? -89.843  36.761 62.170  1.00 64.55  ? 1100 GLU D OE2 1 
ATOM   7746 N N   . SER D 1 251 ? -89.617  31.017 65.433  1.00 61.56  ? 1101 SER D N   1 
ATOM   7747 C CA  . SER D 1 251 ? -89.029  29.724 65.841  1.00 64.81  ? 1101 SER D CA  1 
ATOM   7748 C C   . SER D 1 251 ? -87.509  29.760 65.789  1.00 66.35  ? 1101 SER D C   1 
ATOM   7749 O O   . SER D 1 251 ? -86.965  30.361 64.864  1.00 65.07  ? 1101 SER D O   1 
ATOM   7750 C CB  . SER D 1 251 ? -89.559  28.638 64.961  1.00 69.64  ? 1101 SER D CB  1 
ATOM   7751 O OG  . SER D 1 251 ? -90.927  28.863 64.676  1.00 73.63  ? 1101 SER D OG  1 
ATOM   7752 N N   . ALA D 1 252 ? -86.877  29.068 66.729  1.00 70.55  ? 1102 ALA D N   1 
ATOM   7753 C CA  . ALA D 1 252 ? -85.404  29.040 66.791  1.00 70.68  ? 1102 ALA D CA  1 
ATOM   7754 C C   . ALA D 1 252 ? -84.947  27.651 67.235  1.00 76.42  ? 1102 ALA D C   1 
ATOM   7755 O O   . ALA D 1 252 ? -85.814  26.894 67.699  1.00 78.16  ? 1102 ALA D O   1 
ATOM   7756 C CB  . ALA D 1 252 ? -84.943  30.098 67.744  1.00 67.96  ? 1102 ALA D CB  1 
HETATM 7757 I I   . IOD E 2 .   ? -63.263  42.555 20.466  1.00 46.68  ? 2000 IOD A I   1 
HETATM 7758 I I   . IOD F 2 .   ? -73.994  35.625 14.312  0.48 42.46  ? 2001 IOD A I   1 
HETATM 7759 I I   . IOD G 2 .   ? -80.400  63.395 34.205  1.00 40.31  ? 2000 IOD B I   1 
HETATM 7760 I I   . IOD H 2 .   ? -66.800  64.049 38.383  0.45 49.38  ? 2001 IOD B I   1 
HETATM 7761 I I   . IOD I 2 .   ? -48.472  49.489 56.439  1.00 46.76  ? 2000 IOD C I   1 
HETATM 7762 I I   . IOD J 2 .   ? -37.524  57.497 60.215  0.42 53.23  ? 2001 IOD C I   1 
HETATM 7763 I I   . IOD K 2 .   ? -84.736  36.805 74.727  1.00 46.60  ? 2000 IOD D I   1 
HETATM 7764 O O   . HOH L 3 .   ? -49.123  37.895 -1.166  1.00 56.48  ? 2101 HOH A O   1 
HETATM 7765 O O   . HOH L 3 .   ? -47.025  47.893 15.849  1.00 47.52  ? 2102 HOH A O   1 
HETATM 7766 O O   . HOH L 3 .   ? -63.409  47.331 28.277  1.00 49.71  ? 2103 HOH A O   1 
HETATM 7767 O O   . HOH L 3 .   ? -82.863  49.372 13.748  1.00 63.56  ? 2104 HOH A O   1 
HETATM 7768 O O   . HOH L 3 .   ? -82.806  35.754 3.446   1.00 50.43  ? 2105 HOH A O   1 
HETATM 7769 O O   . HOH L 3 .   ? -40.334  15.703 27.422  1.00 49.65  ? 2106 HOH A O   1 
HETATM 7770 O O   . HOH L 3 .   ? -55.151  52.640 26.485  1.00 50.61  ? 2107 HOH A O   1 
HETATM 7771 O O   . HOH L 3 .   ? -49.750  55.670 11.371  1.00 51.30  ? 2108 HOH A O   1 
HETATM 7772 O O   . HOH L 3 .   ? -65.584  22.546 16.715  1.00 55.54  ? 2109 HOH A O   1 
HETATM 7773 O O   . HOH L 3 .   ? -65.960  52.930 25.090  1.00 44.45  ? 2110 HOH A O   1 
HETATM 7774 O O   . HOH L 3 .   ? -45.766  17.055 22.059  1.00 43.07  ? 2111 HOH A O   1 
HETATM 7775 O O   . HOH L 3 .   ? -53.979  40.618 8.639   1.00 42.10  ? 2112 HOH A O   1 
HETATM 7776 O O   . HOH L 3 .   ? -79.260  45.754 22.104  1.00 55.67  ? 2113 HOH A O   1 
HETATM 7777 O O   . HOH L 3 .   ? -72.853  30.374 3.122   1.00 46.81  ? 2114 HOH A O   1 
HETATM 7778 O O   . HOH L 3 .   ? -77.185  41.451 13.808  1.00 49.23  ? 2115 HOH A O   1 
HETATM 7779 O O   . HOH L 3 .   ? -48.869  51.298 22.095  1.00 49.15  ? 2116 HOH A O   1 
HETATM 7780 O O   . HOH L 3 .   ? -69.444  53.314 17.668  1.00 32.34  ? 2117 HOH A O   1 
HETATM 7781 O O   . HOH L 3 .   ? -45.891  17.577 26.221  1.00 42.93  ? 2118 HOH A O   1 
HETATM 7782 O O   . HOH L 3 .   ? -49.722  46.476 10.740  1.00 60.34  ? 2119 HOH A O   1 
HETATM 7783 O O   . HOH L 3 .   ? -65.733  55.504 24.751  1.00 48.62  ? 2120 HOH A O   1 
HETATM 7784 O O   . HOH L 3 .   ? -73.126  28.181 12.646  1.00 48.56  ? 2121 HOH A O   1 
HETATM 7785 O O   . HOH L 3 .   ? -62.005  51.201 -0.110  1.00 43.77  ? 2122 HOH A O   1 
HETATM 7786 O O   . HOH L 3 .   ? -65.446  44.978 17.938  1.00 36.52  ? 2123 HOH A O   1 
HETATM 7787 O O   . HOH L 3 .   ? -67.484  56.517 17.660  1.00 50.34  ? 2124 HOH A O   1 
HETATM 7788 O O   . HOH L 3 .   ? -48.813  18.241 20.748  1.00 49.99  ? 2125 HOH A O   1 
HETATM 7789 O O   . HOH L 3 .   ? -52.266  45.079 13.493  1.00 41.09  ? 2126 HOH A O   1 
HETATM 7790 O O   . HOH L 3 .   ? -58.393  41.765 23.648  1.00 35.11  ? 2127 HOH A O   1 
HETATM 7791 O O   . HOH L 3 .   ? -63.580  46.003 -6.765  1.00 54.64  ? 2128 HOH A O   1 
HETATM 7792 O O   . HOH L 3 .   ? -60.510  29.741 -3.897  1.00 43.34  ? 2129 HOH A O   1 
HETATM 7793 O O   . HOH L 3 .   ? -69.884  39.674 0.279   1.00 34.39  ? 2130 HOH A O   1 
HETATM 7794 O O   . HOH L 3 .   ? -41.893  25.091 8.862   1.00 47.33  ? 2131 HOH A O   1 
HETATM 7795 O O   . HOH L 3 .   ? -69.657  36.569 1.014   1.00 35.46  ? 2132 HOH A O   1 
HETATM 7796 O O   . HOH L 3 .   ? -49.273  23.744 25.445  1.00 34.22  ? 2133 HOH A O   1 
HETATM 7797 O O   . HOH L 3 .   ? -51.370  55.338 21.635  1.00 52.15  ? 2134 HOH A O   1 
HETATM 7798 O O   . HOH L 3 .   ? -72.598  59.108 14.835  1.00 42.57  ? 2135 HOH A O   1 
HETATM 7799 O O   . HOH L 3 .   ? -40.361  22.774 14.358  1.00 39.93  ? 2136 HOH A O   1 
HETATM 7800 O O   . HOH L 3 .   ? -94.367  46.786 2.296   1.00 48.63  ? 2137 HOH A O   1 
HETATM 7801 O O   . HOH L 3 .   ? -51.410  45.317 28.099  1.00 56.00  ? 2138 HOH A O   1 
HETATM 7802 O O   . HOH L 3 .   ? -49.546  31.238 28.148  1.00 45.76  ? 2139 HOH A O   1 
HETATM 7803 O O   . HOH L 3 .   ? -44.108  33.803 5.232   1.00 44.14  ? 2140 HOH A O   1 
HETATM 7804 O O   . HOH L 3 .   ? -48.665  24.613 1.968   1.00 52.72  ? 2141 HOH A O   1 
HETATM 7805 O O   . HOH L 3 .   ? -51.402  24.934 12.754  1.00 31.34  ? 2142 HOH A O   1 
HETATM 7806 O O   . HOH L 3 .   ? -50.417  24.487 15.247  1.00 31.43  ? 2143 HOH A O   1 
HETATM 7807 O O   . HOH L 3 .   ? -69.834  41.507 -1.915  1.00 32.37  ? 2144 HOH A O   1 
HETATM 7808 O O   . HOH L 3 .   ? -53.813  40.354 27.815  1.00 40.26  ? 2145 HOH A O   1 
HETATM 7809 O O   . HOH L 3 .   ? -56.868  35.140 32.209  1.00 55.82  ? 2146 HOH A O   1 
HETATM 7810 O O   . HOH L 3 .   ? -63.645  32.253 -5.716  1.00 50.08  ? 2147 HOH A O   1 
HETATM 7811 O O   . HOH L 3 .   ? -60.544  22.218 19.976  1.00 55.15  ? 2148 HOH A O   1 
HETATM 7812 O O   . HOH L 3 .   ? -70.680  24.879 0.603   1.00 53.88  ? 2149 HOH A O   1 
HETATM 7813 O O   . HOH L 3 .   ? -41.191  20.539 18.675  1.00 37.88  ? 2150 HOH A O   1 
HETATM 7814 O O   . HOH L 3 .   ? -58.000  45.838 -2.589  1.00 47.65  ? 2151 HOH A O   1 
HETATM 7815 O O   . HOH L 3 .   ? -64.794  47.370 7.303   1.00 28.80  ? 2152 HOH A O   1 
HETATM 7816 O O   . HOH L 3 .   ? -44.427  30.026 12.464  1.00 31.75  ? 2153 HOH A O   1 
HETATM 7817 O O   . HOH L 3 .   ? -55.531  33.422 31.069  1.00 42.00  ? 2154 HOH A O   1 
HETATM 7818 O O   . HOH L 3 .   ? -59.857  55.608 23.253  1.00 49.75  ? 2155 HOH A O   1 
HETATM 7819 O O   . HOH L 3 .   ? -62.016  21.236 15.928  1.00 52.40  ? 2156 HOH A O   1 
HETATM 7820 O O   . HOH L 3 .   ? -76.090  42.050 2.470   1.00 46.73  ? 2157 HOH A O   1 
HETATM 7821 O O   . HOH L 3 .   ? -66.766  29.156 9.388   1.00 31.89  ? 2158 HOH A O   1 
HETATM 7822 O O   . HOH L 3 .   ? -37.555  16.908 31.123  1.00 42.74  ? 2159 HOH A O   1 
HETATM 7823 O O   . HOH L 3 .   ? -55.464  59.360 15.513  1.00 64.47  ? 2160 HOH A O   1 
HETATM 7824 O O   . HOH L 3 .   ? -62.401  41.896 16.825  1.00 30.35  ? 2161 HOH A O   1 
HETATM 7825 O O   . HOH L 3 .   ? -67.272  27.424 20.042  1.00 43.02  ? 2162 HOH A O   1 
HETATM 7826 O O   . HOH L 3 .   ? -57.594  52.194 27.338  1.00 46.34  ? 2163 HOH A O   1 
HETATM 7827 O O   . HOH L 3 .   ? -62.266  54.719 19.675  1.00 45.32  ? 2164 HOH A O   1 
HETATM 7828 O O   . HOH L 3 .   ? -53.287  24.810 24.330  1.00 36.60  ? 2165 HOH A O   1 
HETATM 7829 O O   . HOH L 3 .   ? -59.627  26.391 22.367  1.00 43.77  ? 2166 HOH A O   1 
HETATM 7830 O O   . HOH L 3 .   ? -54.863  25.962 0.028   1.00 46.13  ? 2167 HOH A O   1 
HETATM 7831 O O   . HOH L 3 .   ? -45.622  38.286 25.512  1.00 39.03  ? 2168 HOH A O   1 
HETATM 7832 O O   . HOH L 3 .   ? -54.474  57.541 11.433  1.00 53.12  ? 2169 HOH A O   1 
HETATM 7833 O O   . HOH L 3 .   ? -79.821  37.797 11.732  1.00 47.74  ? 2170 HOH A O   1 
HETATM 7834 O O   . HOH L 3 .   ? -43.184  36.505 24.868  1.00 44.55  ? 2171 HOH A O   1 
HETATM 7835 O O   . HOH L 3 .   ? -53.493  52.509 22.799  1.00 53.85  ? 2172 HOH A O   1 
HETATM 7836 O O   . HOH L 3 .   ? -44.436  19.415 14.816  1.00 41.40  ? 2173 HOH A O   1 
HETATM 7837 O O   . HOH L 3 .   ? -75.009  41.709 22.195  1.00 52.28  ? 2174 HOH A O   1 
HETATM 7838 O O   . HOH L 3 .   ? -64.112  41.823 -7.667  1.00 43.98  ? 2175 HOH A O   1 
HETATM 7839 O O   . HOH L 3 .   ? -44.648  25.433 12.494  1.00 44.37  ? 2176 HOH A O   1 
HETATM 7840 O O   . HOH L 3 .   ? -54.247  21.515 5.888   1.00 50.64  ? 2177 HOH A O   1 
HETATM 7841 O O   . HOH L 3 .   ? -48.533  26.485 27.132  1.00 43.15  ? 2178 HOH A O   1 
HETATM 7842 O O   . HOH L 3 .   ? -58.374  58.008 13.373  1.00 46.59  ? 2179 HOH A O   1 
HETATM 7843 O O   . HOH L 3 .   ? -46.976  42.457 10.039  1.00 41.73  ? 2180 HOH A O   1 
HETATM 7844 O O   . HOH L 3 .   ? -60.462  46.861 5.694   1.00 33.21  ? 2181 HOH A O   1 
HETATM 7845 O O   . HOH L 3 .   ? -58.187  56.237 21.372  1.00 47.73  ? 2182 HOH A O   1 
HETATM 7846 O O   . HOH L 3 .   ? -58.341  18.931 12.968  1.00 54.36  ? 2183 HOH A O   1 
HETATM 7847 O O   . HOH L 3 .   ? -74.585  59.400 -7.573  1.00 49.78  ? 2184 HOH A O   1 
HETATM 7848 O O   . HOH L 3 .   ? -54.625  25.503 22.034  1.00 32.25  ? 2185 HOH A O   1 
HETATM 7849 O O   . HOH L 3 .   ? -38.452  16.140 33.709  1.00 50.18  ? 2186 HOH A O   1 
HETATM 7850 O O   . HOH L 3 .   ? -69.947  57.729 11.471  1.00 44.28  ? 2187 HOH A O   1 
HETATM 7851 O O   . HOH L 3 .   ? -60.478  42.752 -5.939  1.00 49.63  ? 2188 HOH A O   1 
HETATM 7852 O O   . HOH L 3 .   ? -63.072  57.761 22.125  1.00 58.34  ? 2189 HOH A O   1 
HETATM 7853 O O   . HOH L 3 .   ? -62.303  48.214 7.540   1.00 34.22  ? 2190 HOH A O   1 
HETATM 7854 O O   . HOH L 3 .   ? -60.829  57.160 18.556  1.00 52.82  ? 2191 HOH A O   1 
HETATM 7855 O O   . HOH L 3 .   ? -51.510  39.645 30.711  1.00 50.00  ? 2192 HOH A O   1 
HETATM 7856 O O   . HOH L 3 .   ? -71.589  27.048 17.674  1.00 56.62  ? 2193 HOH A O   1 
HETATM 7857 O O   . HOH L 3 .   ? -79.405  55.222 3.983   1.00 57.22  ? 2194 HOH A O   1 
HETATM 7858 O O   . HOH L 3 .   ? -45.991  35.706 26.496  1.00 34.42  ? 2195 HOH A O   1 
HETATM 7859 O O   . HOH L 3 .   ? -54.364  22.323 -1.411  1.00 58.94  ? 2196 HOH A O   1 
HETATM 7860 O O   . HOH L 3 .   ? -76.559  39.780 -0.318  1.00 62.50  ? 2197 HOH A O   1 
HETATM 7861 O O   . HOH L 3 .   ? -45.706  36.151 8.553   1.00 41.84  ? 2198 HOH A O   1 
HETATM 7862 O O   . HOH L 3 .   ? -68.660  33.049 -3.472  1.00 49.98  ? 2199 HOH A O   1 
HETATM 7863 O O   . HOH L 3 .   ? -63.404  23.101 7.156   1.00 53.10  ? 2200 HOH A O   1 
HETATM 7864 O O   . HOH L 3 .   ? -69.145  54.486 23.951  1.00 42.56  ? 2201 HOH A O   1 
HETATM 7865 O O   . HOH L 3 .   ? -71.240  56.806 -11.041 1.00 59.56  ? 2202 HOH A O   1 
HETATM 7866 O O   . HOH L 3 .   ? -54.398  18.942 15.763  1.00 43.93  ? 2203 HOH A O   1 
HETATM 7867 O O   . HOH L 3 .   ? -58.292  21.234 -2.889  1.00 57.76  ? 2204 HOH A O   1 
HETATM 7868 O O   . HOH L 3 .   ? -67.859  21.846 0.662   1.00 51.92  ? 2205 HOH A O   1 
HETATM 7869 O O   . HOH L 3 .   ? -59.656  35.660 -7.156  1.00 52.84  ? 2206 HOH A O   1 
HETATM 7870 O O   . HOH L 3 .   ? -42.175  31.443 13.064  1.00 34.65  ? 2207 HOH A O   1 
HETATM 7871 O O   . HOH L 3 .   ? -59.054  54.961 26.392  1.00 55.68  ? 2208 HOH A O   1 
HETATM 7872 O O   . HOH L 3 .   ? -46.615  43.137 26.603  1.00 45.29  ? 2209 HOH A O   1 
HETATM 7873 O O   . HOH L 3 .   ? -59.442  30.696 30.958  1.00 53.72  ? 2210 HOH A O   1 
HETATM 7874 O O   . HOH L 3 .   ? -66.610  59.081 20.279  1.00 53.05  ? 2211 HOH A O   1 
HETATM 7875 O O   . HOH L 3 .   ? -53.393  29.911 -2.675  1.00 53.75  ? 2212 HOH A O   1 
HETATM 7876 O O   . HOH L 3 .   ? -58.936  47.572 32.809  1.00 60.91  ? 2213 HOH A O   1 
HETATM 7877 O O   . HOH L 3 .   ? -60.174  40.367 30.594  1.00 45.55  ? 2214 HOH A O   1 
HETATM 7878 O O   . HOH L 3 .   ? -64.740  23.868 10.225  1.00 45.60  ? 2215 HOH A O   1 
HETATM 7879 O O   . HOH L 3 .   ? -72.990  36.995 29.588  1.00 49.64  ? 2216 HOH A O   1 
HETATM 7880 O O   . HOH L 3 .   ? -64.716  27.814 20.718  1.00 38.06  ? 2217 HOH A O   1 
HETATM 7881 O O   . HOH L 3 .   ? -58.311  21.606 4.820   1.00 49.67  ? 2218 HOH A O   1 
HETATM 7882 O O   . HOH L 3 .   ? -51.733  42.133 12.538  1.00 43.54  ? 2219 HOH A O   1 
HETATM 7883 O O   . HOH L 3 .   ? -73.405  29.293 5.973   1.00 46.51  ? 2220 HOH A O   1 
HETATM 7884 O O   . HOH L 3 .   ? -52.650  19.484 20.789  1.00 50.84  ? 2221 HOH A O   1 
HETATM 7885 O O   . HOH L 3 .   ? -90.759  51.410 3.164   1.00 50.93  ? 2222 HOH A O   1 
HETATM 7886 O O   . HOH L 3 .   ? -51.951  23.552 8.285   1.00 36.60  ? 2223 HOH A O   1 
HETATM 7887 O O   . HOH L 3 .   ? -47.580  22.163 23.730  1.00 34.97  ? 2224 HOH A O   1 
HETATM 7888 O O   . HOH L 3 .   ? -46.044  18.983 23.933  1.00 34.24  ? 2225 HOH A O   1 
HETATM 7889 O O   . HOH L 3 .   ? -78.803  55.909 15.526  1.00 55.13  ? 2226 HOH A O   1 
HETATM 7890 O O   . HOH L 3 .   ? -63.635  32.444 27.716  1.00 46.85  ? 2227 HOH A O   1 
HETATM 7891 O O   . HOH L 3 .   ? -60.064  39.504 24.044  1.00 45.38  ? 2228 HOH A O   1 
HETATM 7892 O O   . HOH L 3 .   ? -43.738  36.089 6.660   1.00 35.83  ? 2229 HOH A O   1 
HETATM 7893 O O   . HOH L 3 .   ? -42.318  16.079 36.329  1.00 47.15  ? 2230 HOH A O   1 
HETATM 7894 O O   . HOH L 3 .   ? -52.529  52.752 11.062  1.00 40.28  ? 2231 HOH A O   1 
HETATM 7895 O O   . HOH L 3 .   ? -60.851  19.363 12.898  1.00 59.65  ? 2232 HOH A O   1 
HETATM 7896 O O   . HOH L 3 .   ? -40.914  31.071 0.846   1.00 50.71  ? 2233 HOH A O   1 
HETATM 7897 O O   . HOH L 3 .   ? -53.708  43.850 29.161  1.00 52.35  ? 2234 HOH A O   1 
HETATM 7898 O O   . HOH L 3 .   ? -65.276  23.758 14.546  1.00 46.54  ? 2235 HOH A O   1 
HETATM 7899 O O   . HOH L 3 .   ? -62.271  50.998 7.962   1.00 53.32  ? 2236 HOH A O   1 
HETATM 7900 O O   . HOH L 3 .   ? -54.398  43.193 7.896   1.00 41.13  ? 2237 HOH A O   1 
HETATM 7901 O O   . HOH L 3 .   ? -80.138  60.250 16.648  1.00 55.97  ? 2238 HOH A O   1 
HETATM 7902 O O   . HOH L 3 .   ? -64.147  22.575 -2.183  1.00 49.77  ? 2239 HOH A O   1 
HETATM 7903 O O   . HOH L 3 .   ? -66.920  46.598 -9.158  1.00 53.22  ? 2240 HOH A O   1 
HETATM 7904 O O   . HOH L 3 .   ? -57.475  19.174 6.053   1.00 56.97  ? 2241 HOH A O   1 
HETATM 7905 O O   . HOH L 3 .   ? -58.582  50.399 8.866   1.00 47.35  ? 2242 HOH A O   1 
HETATM 7906 O O   . HOH L 3 .   ? -82.735  26.329 9.941   1.00 56.02  ? 2243 HOH A O   1 
HETATM 7907 O O   . HOH L 3 .   ? -61.027  32.660 30.815  1.00 59.19  ? 2244 HOH A O   1 
HETATM 7908 O O   . HOH L 3 .   ? -67.673  55.745 0.822   1.00 59.92  ? 2245 HOH A O   1 
HETATM 7909 O O   . HOH L 3 .   ? -75.662  31.537 -4.170  1.00 57.37  ? 2246 HOH A O   1 
HETATM 7910 O O   . HOH L 3 .   ? -73.100  53.001 0.696   1.00 55.58  ? 2247 HOH A O   1 
HETATM 7911 O O   . HOH L 3 .   ? -67.375  51.275 -10.355 1.00 56.94  ? 2248 HOH A O   1 
HETATM 7912 O O   . HOH L 3 .   ? -73.728  35.013 21.971  1.00 43.58  ? 2249 HOH A O   1 
HETATM 7913 O O   . HOH L 3 .   ? -43.500  15.999 30.029  1.00 49.49  ? 2250 HOH A O   1 
HETATM 7914 O O   . HOH L 3 .   ? -65.325  58.147 9.865   1.00 57.10  ? 2251 HOH A O   1 
HETATM 7915 O O   . HOH L 3 .   ? -49.099  38.209 1.349   1.00 52.20  ? 2252 HOH A O   1 
HETATM 7916 O O   . HOH L 3 .   ? -39.580  41.811 22.291  1.00 51.68  ? 2253 HOH A O   1 
HETATM 7917 O O   . HOH L 3 .   ? -69.692  59.042 14.312  1.00 51.10  ? 2254 HOH A O   1 
HETATM 7918 O O   . HOH L 3 .   ? -43.880  33.958 26.764  1.00 41.47  ? 2255 HOH A O   1 
HETATM 7919 O O   . HOH L 3 .   ? -51.670  57.423 19.660  1.00 60.35  ? 2256 HOH A O   1 
HETATM 7920 O O   . HOH L 3 .   ? -49.369  58.885 19.444  1.00 62.24  ? 2257 HOH A O   1 
HETATM 7921 O O   . HOH L 3 .   ? -69.024  41.132 -6.591  1.00 54.47  ? 2258 HOH A O   1 
HETATM 7922 O O   . HOH L 3 .   ? -65.775  59.714 14.205  1.00 59.72  ? 2259 HOH A O   1 
HETATM 7923 O O   . HOH L 3 .   ? -71.606  34.239 14.105  1.00 43.86  ? 2260 HOH A O   1 
HETATM 7924 O O   . HOH L 3 .   ? -44.911  14.308 18.831  1.00 49.84  ? 2261 HOH A O   1 
HETATM 7925 O O   . HOH L 3 .   ? -50.137  18.911 12.484  1.00 49.35  ? 2262 HOH A O   1 
HETATM 7926 O O   . HOH L 3 .   ? -42.259  24.937 11.390  1.00 50.30  ? 2263 HOH A O   1 
HETATM 7927 O O   . HOH L 3 .   ? -75.749  63.420 16.172  1.00 48.91  ? 2264 HOH A O   1 
HETATM 7928 O O   . HOH L 3 .   ? -82.180  35.737 12.310  1.00 45.39  ? 2265 HOH A O   1 
HETATM 7929 O O   . HOH L 3 .   ? -66.071  59.883 11.083  1.00 63.25  ? 2266 HOH A O   1 
HETATM 7930 O O   . HOH L 3 .   ? -41.637  32.179 5.141   1.00 53.58  ? 2267 HOH A O   1 
HETATM 7931 O O   . HOH L 3 .   ? -65.247  21.143 -0.314  1.00 45.59  ? 2268 HOH A O   1 
HETATM 7932 O O   . HOH L 3 .   ? -44.833  35.367 -0.696  1.00 51.39  ? 2269 HOH A O   1 
HETATM 7933 O O   . HOH L 3 .   ? -59.898  56.103 8.209   1.00 54.94  ? 2270 HOH A O   1 
HETATM 7934 O O   . HOH L 3 .   ? -58.439  58.899 10.577  1.00 60.33  ? 2271 HOH A O   1 
HETATM 7935 O O   . HOH L 3 .   ? -56.822  23.806 21.887  1.00 43.25  ? 2272 HOH A O   1 
HETATM 7936 O O   . HOH L 3 .   ? -58.716  24.060 20.677  1.00 46.85  ? 2273 HOH A O   1 
HETATM 7937 O O   . HOH L 3 .   ? -95.325  34.018 1.215   1.00 61.41  ? 2274 HOH A O   1 
HETATM 7938 O O   . HOH L 3 .   ? -68.319  26.412 9.263   1.00 48.18  ? 2275 HOH A O   1 
HETATM 7939 O O   . HOH L 3 .   ? -61.761  24.572 23.360  1.00 56.88  ? 2276 HOH A O   1 
HETATM 7940 O O   . HOH L 3 .   ? -51.004  21.950 26.196  1.00 38.41  ? 2277 HOH A O   1 
HETATM 7941 O O   . HOH L 3 .   ? -44.462  15.251 25.998  1.00 61.06  ? 2278 HOH A O   1 
HETATM 7942 O O   . HOH L 3 .   ? -48.450  19.746 23.380  1.00 42.24  ? 2279 HOH A O   1 
HETATM 7943 O O   . HOH L 3 .   ? -55.460  55.281 25.679  1.00 59.29  ? 2280 HOH A O   1 
HETATM 7944 O O   . HOH L 3 .   ? -50.689  28.954 28.806  1.00 46.36  ? 2281 HOH A O   1 
HETATM 7945 O O   . HOH L 3 .   ? -74.613  61.348 14.362  1.00 44.81  ? 2282 HOH A O   1 
HETATM 7946 O O   . HOH L 3 .   ? -64.444  26.108 22.695  1.00 49.20  ? 2283 HOH A O   1 
HETATM 7947 O O   . HOH L 3 .   ? -62.155  45.010 -8.747  1.00 66.75  ? 2284 HOH A O   1 
HETATM 7948 O O   . HOH L 3 .   ? -55.047  25.778 26.223  1.00 52.18  ? 2285 HOH A O   1 
HETATM 7949 O O   . HOH L 3 .   ? -48.186  28.098 29.348  1.00 49.96  ? 2286 HOH A O   1 
HETATM 7950 O O   . HOH L 3 .   ? -41.328  20.254 15.775  1.00 47.23  ? 2287 HOH A O   1 
HETATM 7951 O O   . HOH L 3 .   ? -53.391  22.248 24.656  1.00 37.79  ? 2288 HOH A O   1 
HETATM 7952 O O   . HOH L 3 .   ? -62.031  53.993 0.818   1.00 55.78  ? 2289 HOH A O   1 
HETATM 7953 O O   . HOH L 3 .   ? -50.258  23.204 10.671  1.00 52.15  ? 2290 HOH A O   1 
HETATM 7954 O O   . HOH L 3 .   ? -38.291  13.859 28.231  1.00 61.17  ? 2291 HOH A O   1 
HETATM 7955 O O   . HOH L 3 .   ? -54.595  55.224 23.107  1.00 58.25  ? 2292 HOH A O   1 
HETATM 7956 O O   . HOH L 3 .   ? -79.049  58.363 14.656  1.00 48.18  ? 2293 HOH A O   1 
HETATM 7957 O O   . HOH L 3 .   ? -57.370  23.821 24.539  1.00 54.73  ? 2294 HOH A O   1 
HETATM 7958 O O   . HOH L 3 .   ? -62.777  59.027 17.700  1.00 58.70  ? 2295 HOH A O   1 
HETATM 7959 O O   . HOH L 3 .   ? -54.172  20.655 22.898  1.00 49.46  ? 2296 HOH A O   1 
HETATM 7960 O O   . HOH M 3 .   ? -57.999  73.557 25.761  1.00 60.94  ? 2101 HOH B O   1 
HETATM 7961 O O   . HOH M 3 .   ? -91.533  71.233 53.903  1.00 28.95  ? 2102 HOH B O   1 
HETATM 7962 O O   . HOH M 3 .   ? -69.608  52.416 27.978  1.00 51.56  ? 2103 HOH B O   1 
HETATM 7963 O O   . HOH M 3 .   ? -83.751  58.720 27.392  1.00 53.93  ? 2104 HOH B O   1 
HETATM 7964 O O   . HOH M 3 .   ? -64.753  65.634 32.355  1.00 44.36  ? 2105 HOH B O   1 
HETATM 7965 O O   . HOH M 3 .   ? -90.480  58.154 37.445  1.00 43.37  ? 2106 HOH B O   1 
HETATM 7966 O O   . HOH M 3 .   ? -91.070  49.883 59.259  1.00 56.75  ? 2107 HOH B O   1 
HETATM 7967 O O   . HOH M 3 .   ? -94.558  47.400 54.918  1.00 57.59  ? 2108 HOH B O   1 
HETATM 7968 O O   . HOH M 3 .   ? -97.285  54.014 64.844  1.00 47.93  ? 2109 HOH B O   1 
HETATM 7969 O O   . HOH M 3 .   ? -93.825  60.382 34.296  1.00 52.00  ? 2110 HOH B O   1 
HETATM 7970 O O   . HOH M 3 .   ? -85.015  84.618 48.776  1.00 50.72  ? 2111 HOH B O   1 
HETATM 7971 O O   . HOH M 3 .   ? -74.741  79.058 59.576  1.00 61.53  ? 2112 HOH B O   1 
HETATM 7972 O O   . HOH M 3 .   ? -77.782  66.075 31.849  1.00 37.51  ? 2113 HOH B O   1 
HETATM 7973 O O   . HOH M 3 .   ? -60.470  76.375 31.011  1.00 60.41  ? 2114 HOH B O   1 
HETATM 7974 O O   . HOH M 3 .   ? -93.929  55.978 38.319  1.00 50.67  ? 2115 HOH B O   1 
HETATM 7975 O O   . HOH M 3 .   ? -74.271  57.596 54.971  1.00 51.46  ? 2116 HOH B O   1 
HETATM 7976 O O   . HOH M 3 .   ? -65.380  62.665 45.827  1.00 42.72  ? 2117 HOH B O   1 
HETATM 7977 O O   . HOH M 3 .   ? -78.507  77.514 30.165  1.00 48.62  ? 2118 HOH B O   1 
HETATM 7978 O O   . HOH M 3 .   ? -92.085  78.267 54.932  1.00 49.91  ? 2119 HOH B O   1 
HETATM 7979 O O   . HOH M 3 .   ? -68.281  53.867 26.484  1.00 48.70  ? 2120 HOH B O   1 
HETATM 7980 O O   . HOH M 3 .   ? -95.266  74.078 36.161  1.00 41.56  ? 2121 HOH B O   1 
HETATM 7981 O O   . HOH M 3 .   ? -88.576  52.737 42.436  1.00 42.89  ? 2122 HOH B O   1 
HETATM 7982 O O   . HOH M 3 .   ? -70.629  65.959 53.196  1.00 38.13  ? 2123 HOH B O   1 
HETATM 7983 O O   . HOH M 3 .   ? -85.273  61.564 35.721  1.00 34.01  ? 2124 HOH B O   1 
HETATM 7984 O O   . HOH M 3 .   ? -66.591  79.135 39.796  1.00 38.24  ? 2125 HOH B O   1 
HETATM 7985 O O   . HOH M 3 .   ? -88.147  58.642 60.760  1.00 36.34  ? 2126 HOH B O   1 
HETATM 7986 O O   . HOH M 3 .   ? -81.239  55.612 49.861  1.00 41.12  ? 2127 HOH B O   1 
HETATM 7987 O O   . HOH M 3 .   ? -86.338  56.265 52.523  1.00 33.07  ? 2128 HOH B O   1 
HETATM 7988 O O   . HOH M 3 .   ? -78.970  56.743 50.417  1.00 41.11  ? 2129 HOH B O   1 
HETATM 7989 O O   . HOH M 3 .   ? -90.445  77.304 37.858  1.00 46.94  ? 2130 HOH B O   1 
HETATM 7990 O O   . HOH M 3 .   ? -90.119  55.696 54.420  1.00 40.12  ? 2131 HOH B O   1 
HETATM 7991 O O   . HOH M 3 .   ? -76.203  68.148 22.959  1.00 37.21  ? 2132 HOH B O   1 
HETATM 7992 O O   . HOH M 3 .   ? -79.559  66.672 35.846  1.00 26.12  ? 2133 HOH B O   1 
HETATM 7993 O O   . HOH M 3 .   ? -88.522  79.371 34.952  1.00 57.20  ? 2134 HOH B O   1 
HETATM 7994 O O   . HOH M 3 .   ? -87.163  74.105 22.542  1.00 52.66  ? 2135 HOH B O   1 
HETATM 7995 O O   . HOH M 3 .   ? -64.804  80.709 47.496  1.00 49.55  ? 2136 HOH B O   1 
HETATM 7996 O O   . HOH M 3 .   ? -85.996  76.549 23.874  1.00 45.51  ? 2137 HOH B O   1 
HETATM 7997 O O   . HOH M 3 .   ? -81.842  77.589 31.622  1.00 43.29  ? 2138 HOH B O   1 
HETATM 7998 O O   . HOH M 3 .   ? -93.834  67.956 61.448  1.00 42.01  ? 2139 HOH B O   1 
HETATM 7999 O O   . HOH M 3 .   ? -69.873  67.970 47.792  1.00 32.74  ? 2140 HOH B O   1 
HETATM 8000 O O   . HOH M 3 .   ? -76.313  63.565 56.810  1.00 33.53  ? 2141 HOH B O   1 
HETATM 8001 O O   . HOH M 3 .   ? -70.583  59.665 28.073  1.00 47.04  ? 2142 HOH B O   1 
HETATM 8002 O O   . HOH M 3 .   ? -97.055  51.622 41.564  1.00 64.99  ? 2143 HOH B O   1 
HETATM 8003 O O   . HOH M 3 .   ? -92.522  56.247 47.270  1.00 43.40  ? 2144 HOH B O   1 
HETATM 8004 O O   . HOH M 3 .   ? -90.085  57.868 62.538  1.00 42.15  ? 2145 HOH B O   1 
HETATM 8005 O O   . HOH M 3 .   ? -85.698  65.216 56.323  1.00 27.08  ? 2146 HOH B O   1 
HETATM 8006 O O   . HOH M 3 .   ? -65.834  81.193 23.420  1.00 63.84  ? 2147 HOH B O   1 
HETATM 8007 O O   . HOH M 3 .   ? -74.776  75.144 20.458  1.00 48.17  ? 2148 HOH B O   1 
HETATM 8008 O O   . HOH M 3 .   ? -84.040  58.068 58.590  1.00 36.02  ? 2149 HOH B O   1 
HETATM 8009 O O   . HOH M 3 .   ? -63.900  79.963 55.748  1.00 53.91  ? 2150 HOH B O   1 
HETATM 8010 O O   . HOH M 3 .   ? -66.115  77.610 42.472  1.00 43.81  ? 2151 HOH B O   1 
HETATM 8011 O O   . HOH M 3 .   ? -76.197  85.228 31.780  1.00 52.38  ? 2152 HOH B O   1 
HETATM 8012 O O   . HOH M 3 .   ? -90.427  79.236 52.381  1.00 42.30  ? 2153 HOH B O   1 
HETATM 8013 O O   . HOH M 3 .   ? -85.287  78.609 60.042  1.00 49.81  ? 2154 HOH B O   1 
HETATM 8014 O O   . HOH M 3 .   ? -59.057  69.775 36.299  1.00 56.14  ? 2155 HOH B O   1 
HETATM 8015 O O   . HOH M 3 .   ? -82.045  72.939 60.300  1.00 51.15  ? 2156 HOH B O   1 
HETATM 8016 O O   . HOH M 3 .   ? -88.170  77.941 40.385  1.00 47.54  ? 2157 HOH B O   1 
HETATM 8017 O O   . HOH M 3 .   ? -88.494  73.576 37.575  1.00 37.52  ? 2158 HOH B O   1 
HETATM 8018 O O   . HOH M 3 .   ? -78.022  77.464 32.680  1.00 35.09  ? 2159 HOH B O   1 
HETATM 8019 O O   . HOH M 3 .   ? -75.359  76.678 32.831  1.00 30.79  ? 2160 HOH B O   1 
HETATM 8020 O O   . HOH M 3 .   ? -64.282  72.773 55.044  1.00 43.43  ? 2161 HOH B O   1 
HETATM 8021 O O   . HOH M 3 .   ? -84.048  67.394 56.035  1.00 28.49  ? 2162 HOH B O   1 
HETATM 8022 O O   . HOH M 3 .   ? -89.826  57.930 58.781  1.00 40.67  ? 2163 HOH B O   1 
HETATM 8023 O O   . HOH M 3 .   ? -69.883  81.491 55.338  1.00 52.43  ? 2164 HOH B O   1 
HETATM 8024 O O   . HOH M 3 .   ? -78.156  69.202 21.457  1.00 44.18  ? 2165 HOH B O   1 
HETATM 8025 O O   . HOH M 3 .   ? -91.869  55.581 51.904  1.00 42.59  ? 2166 HOH B O   1 
HETATM 8026 O O   . HOH M 3 .   ? -73.896  72.445 18.050  1.00 50.61  ? 2167 HOH B O   1 
HETATM 8027 O O   . HOH M 3 .   ? -71.220  81.812 52.990  1.00 51.45  ? 2168 HOH B O   1 
HETATM 8028 O O   . HOH M 3 .   ? -78.502  79.079 34.972  1.00 34.32  ? 2169 HOH B O   1 
HETATM 8029 O O   . HOH M 3 .   ? -77.176  78.167 57.385  1.00 41.59  ? 2170 HOH B O   1 
HETATM 8030 O O   . HOH M 3 .   ? -92.361  63.846 26.839  1.00 50.52  ? 2171 HOH B O   1 
HETATM 8031 O O   . HOH M 3 .   ? -97.049  62.412 37.370  1.00 44.78  ? 2172 HOH B O   1 
HETATM 8032 O O   . HOH M 3 .   ? -96.234  59.891 44.825  1.00 34.35  ? 2173 HOH B O   1 
HETATM 8033 O O   . HOH M 3 .   ? -94.056  71.526 53.037  1.00 32.17  ? 2174 HOH B O   1 
HETATM 8034 O O   . HOH M 3 .   ? -66.270  81.689 38.755  1.00 37.18  ? 2175 HOH B O   1 
HETATM 8035 O O   . HOH M 3 .   ? -74.060  77.980 19.875  1.00 60.15  ? 2176 HOH B O   1 
HETATM 8036 O O   . HOH M 3 .   ? -77.386  53.098 42.944  1.00 59.65  ? 2177 HOH B O   1 
HETATM 8037 O O   . HOH M 3 .   ? -75.410  57.632 47.070  1.00 33.53  ? 2178 HOH B O   1 
HETATM 8038 O O   . HOH M 3 .   ? -84.455  58.345 52.257  1.00 27.93  ? 2179 HOH B O   1 
HETATM 8039 O O   . HOH M 3 .   ? -73.684  60.515 55.077  1.00 45.82  ? 2180 HOH B O   1 
HETATM 8040 O O   . HOH M 3 .   ? -71.078  57.449 44.373  1.00 54.63  ? 2181 HOH B O   1 
HETATM 8041 O O   . HOH M 3 .   ? -84.658  79.618 33.009  1.00 51.79  ? 2182 HOH B O   1 
HETATM 8042 O O   . HOH M 3 .   ? -90.374  69.393 58.095  1.00 38.81  ? 2183 HOH B O   1 
HETATM 8043 O O   . HOH M 3 .   ? -85.600  54.354 34.686  1.00 45.16  ? 2184 HOH B O   1 
HETATM 8044 O O   . HOH M 3 .   ? -68.521  73.843 55.809  1.00 48.36  ? 2185 HOH B O   1 
HETATM 8045 O O   . HOH M 3 .   ? -98.877  62.135 45.611  1.00 47.31  ? 2186 HOH B O   1 
HETATM 8046 O O   . HOH M 3 .   ? -92.586  79.999 26.464  1.00 55.08  ? 2187 HOH B O   1 
HETATM 8047 O O   . HOH M 3 .   ? -95.380  50.588 62.400  1.00 43.77  ? 2188 HOH B O   1 
HETATM 8048 O O   . HOH M 3 .   ? -72.443  86.984 48.548  1.00 50.71  ? 2189 HOH B O   1 
HETATM 8049 O O   . HOH M 3 .   ? -76.880  79.243 25.548  1.00 51.94  ? 2190 HOH B O   1 
HETATM 8050 O O   . HOH M 3 .   ? -79.756  58.374 52.662  1.00 39.61  ? 2191 HOH B O   1 
HETATM 8051 O O   . HOH M 3 .   ? -65.794  89.480 28.405  1.00 59.34  ? 2192 HOH B O   1 
HETATM 8052 O O   . HOH M 3 .   ? -72.669  84.724 25.964  1.00 62.62  ? 2193 HOH B O   1 
HETATM 8053 O O   . HOH M 3 .   ? -81.702  70.796 58.183  1.00 32.25  ? 2194 HOH B O   1 
HETATM 8054 O O   . HOH M 3 .   ? -94.134  63.410 62.171  1.00 39.24  ? 2195 HOH B O   1 
HETATM 8055 O O   . HOH M 3 .   ? -66.077  61.473 19.560  1.00 66.27  ? 2196 HOH B O   1 
HETATM 8056 O O   . HOH M 3 .   ? -98.642  75.166 24.602  1.00 52.69  ? 2197 HOH B O   1 
HETATM 8057 O O   . HOH M 3 .   ? -64.568  74.742 19.081  1.00 49.39  ? 2198 HOH B O   1 
HETATM 8058 O O   . HOH M 3 .   ? -94.672  70.370 26.578  1.00 45.38  ? 2199 HOH B O   1 
HETATM 8059 O O   . HOH M 3 .   ? -88.794  68.367 23.772  1.00 51.10  ? 2200 HOH B O   1 
HETATM 8060 O O   . HOH M 3 .   ? -74.443  71.819 58.984  1.00 43.04  ? 2201 HOH B O   1 
HETATM 8061 O O   . HOH M 3 .   ? -83.903  50.993 41.153  1.00 55.89  ? 2202 HOH B O   1 
HETATM 8062 O O   . HOH M 3 .   ? -101.905 64.845 33.474  1.00 60.90  ? 2203 HOH B O   1 
HETATM 8063 O O   . HOH M 3 .   ? -79.992  53.291 41.459  1.00 51.48  ? 2204 HOH B O   1 
HETATM 8064 O O   . HOH M 3 .   ? -72.347  57.056 49.824  1.00 52.25  ? 2205 HOH B O   1 
HETATM 8065 O O   . HOH M 3 .   ? -68.768  83.435 50.673  1.00 53.36  ? 2206 HOH B O   1 
HETATM 8066 O O   . HOH M 3 .   ? -68.557  64.028 41.018  1.00 43.51  ? 2207 HOH B O   1 
HETATM 8067 O O   . HOH M 3 .   ? -90.178  76.739 49.003  1.00 42.23  ? 2208 HOH B O   1 
HETATM 8068 O O   . HOH M 3 .   ? -60.464  75.697 59.379  1.00 52.93  ? 2209 HOH B O   1 
HETATM 8069 O O   . HOH M 3 .   ? -73.620  65.763 16.515  1.00 52.13  ? 2210 HOH B O   1 
HETATM 8070 O O   . HOH M 3 .   ? -89.613  65.655 62.907  1.00 35.76  ? 2211 HOH B O   1 
HETATM 8071 O O   . HOH M 3 .   ? -86.381  70.124 59.182  1.00 53.78  ? 2212 HOH B O   1 
HETATM 8072 O O   . HOH M 3 .   ? -91.536  52.327 44.958  1.00 45.19  ? 2213 HOH B O   1 
HETATM 8073 O O   . HOH M 3 .   ? -61.826  83.873 35.413  1.00 56.86  ? 2214 HOH B O   1 
HETATM 8074 O O   . HOH M 3 .   ? -89.199  78.286 30.949  1.00 37.21  ? 2215 HOH B O   1 
HETATM 8075 O O   . HOH M 3 .   ? -99.400  63.096 43.028  1.00 50.84  ? 2216 HOH B O   1 
HETATM 8076 O O   . HOH M 3 .   ? -84.990  82.446 47.558  1.00 39.41  ? 2217 HOH B O   1 
HETATM 8077 O O   . HOH M 3 .   ? -87.507  79.403 47.716  1.00 45.87  ? 2218 HOH B O   1 
HETATM 8078 O O   . HOH M 3 .   ? -91.372  56.436 60.666  1.00 41.10  ? 2219 HOH B O   1 
HETATM 8079 O O   . HOH M 3 .   ? -71.509  89.202 38.175  1.00 56.85  ? 2220 HOH B O   1 
HETATM 8080 O O   . HOH M 3 .   ? -78.600  70.980 59.876  1.00 45.24  ? 2221 HOH B O   1 
HETATM 8081 O O   . HOH M 3 .   ? -91.536  78.630 50.011  1.00 40.71  ? 2222 HOH B O   1 
HETATM 8082 O O   . HOH M 3 .   ? -71.920  61.850 52.070  1.00 47.24  ? 2223 HOH B O   1 
HETATM 8083 O O   . HOH M 3 .   ? -85.584  51.694 37.363  1.00 56.14  ? 2224 HOH B O   1 
HETATM 8084 O O   . HOH M 3 .   ? -97.022  61.842 42.804  1.00 43.16  ? 2225 HOH B O   1 
HETATM 8085 O O   . HOH M 3 .   ? -82.910  78.382 60.164  1.00 49.62  ? 2226 HOH B O   1 
HETATM 8086 O O   . HOH M 3 .   ? -78.116  73.081 18.960  1.00 58.01  ? 2227 HOH B O   1 
HETATM 8087 O O   . HOH M 3 .   ? -73.399  50.890 33.893  1.00 53.19  ? 2228 HOH B O   1 
HETATM 8088 O O   . HOH M 3 .   ? -79.965  68.648 60.301  1.00 43.59  ? 2229 HOH B O   1 
HETATM 8089 O O   . HOH M 3 .   ? -62.018  76.830 35.357  1.00 49.12  ? 2230 HOH B O   1 
HETATM 8090 O O   . HOH M 3 .   ? -100.540 61.614 41.310  1.00 52.95  ? 2231 HOH B O   1 
HETATM 8091 O O   . HOH M 3 .   ? -70.100  78.376 19.720  1.00 49.06  ? 2232 HOH B O   1 
HETATM 8092 O O   . HOH M 3 .   ? -62.706  69.171 46.984  1.00 48.85  ? 2233 HOH B O   1 
HETATM 8093 O O   . HOH M 3 .   ? -88.056  67.669 62.760  1.00 56.65  ? 2234 HOH B O   1 
HETATM 8094 O O   . HOH M 3 .   ? -69.519  59.454 30.636  1.00 53.79  ? 2235 HOH B O   1 
HETATM 8095 O O   . HOH M 3 .   ? -84.878  66.812 61.121  1.00 47.10  ? 2236 HOH B O   1 
HETATM 8096 O O   . HOH M 3 .   ? -69.430  57.092 37.086  1.00 49.77  ? 2237 HOH B O   1 
HETATM 8097 O O   . HOH M 3 .   ? -70.570  68.950 55.313  1.00 53.05  ? 2238 HOH B O   1 
HETATM 8098 O O   . HOH M 3 .   ? -71.960  67.434 58.433  1.00 50.19  ? 2239 HOH B O   1 
HETATM 8099 O O   . HOH M 3 .   ? -91.180  57.564 33.999  1.00 52.13  ? 2240 HOH B O   1 
HETATM 8100 O O   . HOH M 3 .   ? -67.853  63.681 49.889  1.00 49.34  ? 2241 HOH B O   1 
HETATM 8101 O O   . HOH M 3 .   ? -72.718  57.301 46.769  1.00 47.99  ? 2242 HOH B O   1 
HETATM 8102 O O   . HOH M 3 .   ? -85.285  70.498 22.498  1.00 49.43  ? 2243 HOH B O   1 
HETATM 8103 O O   . HOH M 3 .   ? -83.351  63.435 65.342  1.00 41.72  ? 2244 HOH B O   1 
HETATM 8104 O O   . HOH M 3 .   ? -100.907 48.375 63.543  1.00 54.59  ? 2245 HOH B O   1 
HETATM 8105 O O   . HOH M 3 .   ? -102.172 67.369 42.784  1.00 47.56  ? 2246 HOH B O   1 
HETATM 8106 O O   . HOH M 3 .   ? -78.235  73.372 64.337  1.00 68.37  ? 2247 HOH B O   1 
HETATM 8107 O O   . HOH M 3 .   ? -96.843  73.605 24.500  1.00 51.35  ? 2248 HOH B O   1 
HETATM 8108 O O   . HOH M 3 .   ? -81.780  51.831 43.009  1.00 52.45  ? 2249 HOH B O   1 
HETATM 8109 O O   . HOH M 3 .   ? -97.286  75.639 35.751  1.00 48.36  ? 2250 HOH B O   1 
HETATM 8110 O O   . HOH M 3 .   ? -75.382  70.459 60.668  1.00 54.25  ? 2251 HOH B O   1 
HETATM 8111 O O   . HOH M 3 .   ? -76.959  82.419 51.630  1.00 51.41  ? 2252 HOH B O   1 
HETATM 8112 O O   . HOH M 3 .   ? -80.923  80.557 58.672  1.00 53.86  ? 2253 HOH B O   1 
HETATM 8113 O O   . HOH M 3 .   ? -81.843  55.152 37.448  1.00 52.05  ? 2254 HOH B O   1 
HETATM 8114 O O   . HOH M 3 .   ? -83.718  68.905 23.311  1.00 47.05  ? 2255 HOH B O   1 
HETATM 8115 O O   . HOH M 3 .   ? -69.092  60.248 36.683  1.00 53.86  ? 2256 HOH B O   1 
HETATM 8116 O O   . HOH M 3 .   ? -74.096  81.979 53.574  1.00 58.53  ? 2257 HOH B O   1 
HETATM 8117 O O   . HOH M 3 .   ? -77.958  68.259 63.255  1.00 55.46  ? 2258 HOH B O   1 
HETATM 8118 O O   . HOH M 3 .   ? -89.915  73.699 39.810  1.00 42.97  ? 2259 HOH B O   1 
HETATM 8119 O O   . HOH M 3 .   ? -67.883  69.358 54.157  1.00 54.34  ? 2260 HOH B O   1 
HETATM 8120 O O   . HOH M 3 .   ? -81.716  79.944 26.842  1.00 52.92  ? 2261 HOH B O   1 
HETATM 8121 O O   . HOH M 3 .   ? -80.135  67.680 20.445  1.00 51.51  ? 2262 HOH B O   1 
HETATM 8122 O O   . HOH M 3 .   ? -61.951  78.607 33.039  1.00 57.00  ? 2263 HOH B O   1 
HETATM 8123 O O   . HOH M 3 .   ? -98.987  68.529 36.584  1.00 50.43  ? 2264 HOH B O   1 
HETATM 8124 O O   . HOH M 3 .   ? -70.267  61.516 34.608  1.00 44.29  ? 2265 HOH B O   1 
HETATM 8125 O O   . HOH M 3 .   ? -63.519  82.166 39.624  1.00 56.99  ? 2266 HOH B O   1 
HETATM 8126 O O   . HOH M 3 .   ? -91.704  71.011 59.346  1.00 48.29  ? 2267 HOH B O   1 
HETATM 8127 O O   . HOH M 3 .   ? -89.314  53.874 50.468  1.00 52.59  ? 2268 HOH B O   1 
HETATM 8128 O O   . HOH M 3 .   ? -58.285  73.326 47.177  1.00 63.27  ? 2269 HOH B O   1 
HETATM 8129 O O   . HOH M 3 .   ? -69.294  80.055 21.239  1.00 59.08  ? 2270 HOH B O   1 
HETATM 8130 O O   . HOH M 3 .   ? -94.168  72.039 24.673  1.00 52.09  ? 2271 HOH B O   1 
HETATM 8131 O O   . HOH M 3 .   ? -98.185  53.719 38.847  1.00 63.22  ? 2272 HOH B O   1 
HETATM 8132 O O   . HOH M 3 .   ? -75.248  62.496 34.125  1.00 54.38  ? 2273 HOH B O   1 
HETATM 8133 O O   . HOH M 3 .   ? -61.573  76.777 28.054  1.00 58.61  ? 2274 HOH B O   1 
HETATM 8134 O O   . HOH M 3 .   ? -82.215  57.423 53.314  1.00 37.89  ? 2275 HOH B O   1 
HETATM 8135 O O   . HOH M 3 .   ? -64.364  65.325 23.808  1.00 63.78  ? 2276 HOH B O   1 
HETATM 8136 O O   . HOH M 3 .   ? -80.309  59.124 58.736  1.00 45.22  ? 2277 HOH B O   1 
HETATM 8137 O O   . HOH M 3 .   ? -67.771  66.707 49.767  1.00 52.65  ? 2278 HOH B O   1 
HETATM 8138 O O   . HOH M 3 .   ? -91.908  80.748 48.335  1.00 55.41  ? 2279 HOH B O   1 
HETATM 8139 O O   . HOH M 3 .   ? -82.754  79.723 30.438  1.00 53.26  ? 2280 HOH B O   1 
HETATM 8140 O O   . HOH M 3 .   ? -100.373 79.218 50.956  1.00 62.56  ? 2281 HOH B O   1 
HETATM 8141 O O   . HOH M 3 .   ? -85.421  54.562 50.802  1.00 55.36  ? 2282 HOH B O   1 
HETATM 8142 O O   . HOH M 3 .   ? -80.937  52.971 48.373  1.00 49.74  ? 2283 HOH B O   1 
HETATM 8143 O O   . HOH M 3 .   ? -82.463  60.714 35.780  1.00 48.58  ? 2284 HOH B O   1 
HETATM 8144 O O   . HOH M 3 .   ? -91.336  54.323 48.908  1.00 46.14  ? 2285 HOH B O   1 
HETATM 8145 O O   . HOH M 3 .   ? -77.390  63.512 32.867  1.00 43.86  ? 2286 HOH B O   1 
HETATM 8146 O O   . HOH M 3 .   ? -88.378  54.182 55.631  1.00 48.11  ? 2287 HOH B O   1 
HETATM 8147 O O   . HOH M 3 .   ? -83.802  68.844 58.270  1.00 39.97  ? 2288 HOH B O   1 
HETATM 8148 O O   . HOH M 3 .   ? -93.344  54.376 50.344  1.00 49.84  ? 2289 HOH B O   1 
HETATM 8149 O O   . HOH M 3 .   ? -78.641  88.402 43.023  1.00 61.59  ? 2290 HOH B O   1 
HETATM 8150 O O   . HOH M 3 .   ? -61.746  71.075 44.214  1.00 60.03  ? 2291 HOH B O   1 
HETATM 8151 O O   . HOH M 3 .   ? -92.717  65.880 62.671  1.00 45.79  ? 2292 HOH B O   1 
HETATM 8152 O O   . HOH M 3 .   ? -100.175 78.069 33.707  1.00 64.38  ? 2293 HOH B O   1 
HETATM 8153 O O   . HOH M 3 .   ? -74.702  83.869 26.230  1.00 62.11  ? 2294 HOH B O   1 
HETATM 8154 O O   . HOH M 3 .   ? -85.738  55.121 54.903  1.00 40.64  ? 2295 HOH B O   1 
HETATM 8155 O O   . HOH M 3 .   ? -89.233  52.577 53.716  1.00 58.52  ? 2296 HOH B O   1 
HETATM 8156 O O   . HOH M 3 .   ? -75.715  55.116 48.172  1.00 48.43  ? 2297 HOH B O   1 
HETATM 8157 O O   . HOH M 3 .   ? -82.379  54.931 52.374  1.00 44.00  ? 2298 HOH B O   1 
HETATM 8158 O O   . HOH M 3 .   ? -87.647  79.399 44.901  1.00 51.92  ? 2299 HOH B O   1 
HETATM 8159 O O   . HOH M 3 .   ? -56.883  76.671 59.949  1.00 57.20  ? 2300 HOH B O   1 
HETATM 8160 O O   . HOH M 3 .   ? -84.366  51.940 49.368  1.00 68.90  ? 2301 HOH B O   1 
HETATM 8161 O O   . HOH M 3 .   ? -89.394  55.788 57.487  1.00 49.56  ? 2302 HOH B O   1 
HETATM 8162 O O   . HOH M 3 .   ? -62.542  86.051 37.352  1.00 65.79  ? 2303 HOH B O   1 
HETATM 8163 O O   . HOH M 3 .   ? -83.828  56.365 56.428  1.00 43.96  ? 2304 HOH B O   1 
HETATM 8164 O O   . HOH M 3 .   ? -66.011  67.979 51.527  1.00 56.80  ? 2305 HOH B O   1 
HETATM 8165 O O   . HOH M 3 .   ? -79.741  53.993 53.862  1.00 61.32  ? 2306 HOH B O   1 
HETATM 8166 O O   . HOH N 3 .   ? -50.286  63.256 73.462  1.00 54.63  ? 2101 HOH C O   1 
HETATM 8167 O O   . HOH N 3 .   ? -56.405  40.224 49.726  1.00 60.62  ? 2102 HOH C O   1 
HETATM 8168 O O   . HOH N 3 .   ? -28.796  51.762 58.597  1.00 64.07  ? 2103 HOH C O   1 
HETATM 8169 O O   . HOH N 3 .   ? -41.911  46.941 45.467  1.00 49.54  ? 2104 HOH C O   1 
HETATM 8170 O O   . HOH N 3 .   ? -66.246  59.259 79.837  1.00 44.10  ? 2105 HOH C O   1 
HETATM 8171 O O   . HOH N 3 .   ? -32.564  47.580 49.530  1.00 61.00  ? 2106 HOH C O   1 
HETATM 8172 O O   . HOH N 3 .   ? -60.414  41.690 63.024  1.00 53.62  ? 2107 HOH C O   1 
HETATM 8173 O O   . HOH N 3 .   ? -36.459  64.748 66.052  1.00 55.54  ? 2108 HOH C O   1 
HETATM 8174 O O   . HOH N 3 .   ? -71.573  54.933 83.311  1.00 47.27  ? 2109 HOH C O   1 
HETATM 8175 O O   . HOH N 3 .   ? -38.670  62.506 66.367  1.00 45.55  ? 2110 HOH C O   1 
HETATM 8176 O O   . HOH N 3 .   ? -52.721  69.547 43.622  1.00 54.40  ? 2111 HOH C O   1 
HETATM 8177 O O   . HOH N 3 .   ? -52.999  53.624 72.758  1.00 37.23  ? 2112 HOH C O   1 
HETATM 8178 O O   . HOH N 3 .   ? -59.016  59.877 76.925  1.00 49.42  ? 2113 HOH C O   1 
HETATM 8179 O O   . HOH N 3 .   ? -62.762  47.479 69.451  1.00 47.19  ? 2114 HOH C O   1 
HETATM 8180 O O   . HOH N 3 .   ? -67.234  64.222 68.190  1.00 37.98  ? 2115 HOH C O   1 
HETATM 8181 O O   . HOH N 3 .   ? -41.138  68.874 50.413  1.00 42.53  ? 2116 HOH C O   1 
HETATM 8182 O O   . HOH N 3 .   ? -38.664  69.432 59.917  1.00 54.36  ? 2117 HOH C O   1 
HETATM 8183 O O   . HOH N 3 .   ? -45.943  50.838 53.117  1.00 39.46  ? 2118 HOH C O   1 
HETATM 8184 O O   . HOH N 3 .   ? -71.473  63.553 71.308  1.00 38.23  ? 2119 HOH C O   1 
HETATM 8185 O O   . HOH N 3 .   ? -43.293  46.135 43.133  1.00 54.97  ? 2120 HOH C O   1 
HETATM 8186 O O   . HOH N 3 .   ? -48.301  78.349 54.928  1.00 62.48  ? 2121 HOH C O   1 
HETATM 8187 O O   . HOH N 3 .   ? -47.210  66.950 69.259  1.00 56.92  ? 2122 HOH C O   1 
HETATM 8188 O O   . HOH N 3 .   ? -62.558  53.197 75.097  1.00 35.78  ? 2123 HOH C O   1 
HETATM 8189 O O   . HOH N 3 .   ? -51.584  55.813 72.356  1.00 37.39  ? 2124 HOH C O   1 
HETATM 8190 O O   . HOH N 3 .   ? -51.472  59.749 74.641  1.00 58.80  ? 2125 HOH C O   1 
HETATM 8191 O O   . HOH N 3 .   ? -53.075  47.157 58.320  1.00 35.48  ? 2126 HOH C O   1 
HETATM 8192 O O   . HOH N 3 .   ? -66.064  55.207 81.015  1.00 39.44  ? 2127 HOH C O   1 
HETATM 8193 O O   . HOH N 3 .   ? -31.675  58.915 57.215  1.00 42.95  ? 2128 HOH C O   1 
HETATM 8194 O O   . HOH N 3 .   ? -66.962  62.765 80.434  1.00 52.82  ? 2129 HOH C O   1 
HETATM 8195 O O   . HOH N 3 .   ? -60.325  64.332 68.582  1.00 32.87  ? 2130 HOH C O   1 
HETATM 8196 O O   . HOH N 3 .   ? -60.492  44.012 44.601  1.00 57.68  ? 2131 HOH C O   1 
HETATM 8197 O O   . HOH N 3 .   ? -41.648  40.786 46.991  1.00 58.22  ? 2132 HOH C O   1 
HETATM 8198 O O   . HOH N 3 .   ? -46.415  59.369 46.474  1.00 38.47  ? 2133 HOH C O   1 
HETATM 8199 O O   . HOH N 3 .   ? -34.235  55.534 54.600  1.00 49.31  ? 2134 HOH C O   1 
HETATM 8200 O O   . HOH N 3 .   ? -61.514  52.880 40.193  1.00 53.80  ? 2135 HOH C O   1 
HETATM 8201 O O   . HOH N 3 .   ? -28.365  52.156 47.539  1.00 59.29  ? 2136 HOH C O   1 
HETATM 8202 O O   . HOH N 3 .   ? -50.755  61.262 46.018  1.00 39.22  ? 2137 HOH C O   1 
HETATM 8203 O O   . HOH N 3 .   ? -48.814  64.450 39.657  1.00 46.36  ? 2138 HOH C O   1 
HETATM 8204 O O   . HOH N 3 .   ? -62.953  70.275 51.451  1.00 46.67  ? 2139 HOH C O   1 
HETATM 8205 O O   . HOH N 3 .   ? -70.648  60.440 75.046  1.00 37.46  ? 2140 HOH C O   1 
HETATM 8206 O O   . HOH N 3 .   ? -56.694  51.957 38.742  1.00 56.98  ? 2141 HOH C O   1 
HETATM 8207 O O   . HOH N 3 .   ? -49.108  52.969 55.376  1.00 33.05  ? 2142 HOH C O   1 
HETATM 8208 O O   . HOH N 3 .   ? -52.872  49.469 39.244  1.00 49.28  ? 2143 HOH C O   1 
HETATM 8209 O O   . HOH N 3 .   ? -44.707  65.243 63.718  1.00 35.03  ? 2144 HOH C O   1 
HETATM 8210 O O   . HOH N 3 .   ? -65.469  73.659 63.504  1.00 51.11  ? 2145 HOH C O   1 
HETATM 8211 O O   . HOH N 3 .   ? -55.796  44.213 69.154  1.00 39.76  ? 2146 HOH C O   1 
HETATM 8212 O O   . HOH N 3 .   ? -41.449  69.797 53.656  1.00 45.89  ? 2147 HOH C O   1 
HETATM 8213 O O   . HOH N 3 .   ? -62.955  50.394 73.322  1.00 44.09  ? 2148 HOH C O   1 
HETATM 8214 O O   . HOH N 3 .   ? -44.495  56.367 69.573  1.00 42.31  ? 2149 HOH C O   1 
HETATM 8215 O O   . HOH N 3 .   ? -65.025  51.803 48.843  1.00 49.24  ? 2150 HOH C O   1 
HETATM 8216 O O   . HOH N 3 .   ? -68.505  48.119 63.547  1.00 48.55  ? 2151 HOH C O   1 
HETATM 8217 O O   . HOH N 3 .   ? -56.801  74.966 62.097  1.00 41.72  ? 2152 HOH C O   1 
HETATM 8218 O O   . HOH N 3 .   ? -57.668  61.476 53.004  1.00 42.12  ? 2153 HOH C O   1 
HETATM 8219 O O   . HOH N 3 .   ? -67.302  62.265 63.961  1.00 27.81  ? 2154 HOH C O   1 
HETATM 8220 O O   . HOH N 3 .   ? -51.576  77.126 50.405  1.00 51.66  ? 2155 HOH C O   1 
HETATM 8221 O O   . HOH N 3 .   ? -58.471  53.780 73.693  1.00 33.48  ? 2156 HOH C O   1 
HETATM 8222 O O   . HOH N 3 .   ? -46.589  62.196 72.769  1.00 53.48  ? 2157 HOH C O   1 
HETATM 8223 O O   . HOH N 3 .   ? -61.496  62.343 70.132  1.00 29.68  ? 2158 HOH C O   1 
HETATM 8224 O O   . HOH N 3 .   ? -65.613  47.090 64.769  1.00 33.65  ? 2159 HOH C O   1 
HETATM 8225 O O   . HOH N 3 .   ? -68.311  47.268 61.111  1.00 55.05  ? 2160 HOH C O   1 
HETATM 8226 O O   . HOH N 3 .   ? -73.457  48.673 85.838  1.00 53.65  ? 2161 HOH C O   1 
HETATM 8227 O O   . HOH N 3 .   ? -40.529  59.196 70.026  1.00 45.37  ? 2162 HOH C O   1 
HETATM 8228 O O   . HOH N 3 .   ? -64.643  59.227 51.876  1.00 41.42  ? 2163 HOH C O   1 
HETATM 8229 O O   . HOH N 3 .   ? -57.313  55.695 72.176  1.00 31.49  ? 2164 HOH C O   1 
HETATM 8230 O O   . HOH N 3 .   ? -53.827  43.074 44.440  1.00 46.08  ? 2165 HOH C O   1 
HETATM 8231 O O   . HOH N 3 .   ? -60.997  71.587 67.611  1.00 50.92  ? 2166 HOH C O   1 
HETATM 8232 O O   . HOH N 3 .   ? -67.750  67.404 57.262  1.00 42.13  ? 2167 HOH C O   1 
HETATM 8233 O O   . HOH N 3 .   ? -37.136  53.964 36.753  1.00 56.15  ? 2168 HOH C O   1 
HETATM 8234 O O   . HOH N 3 .   ? -58.622  75.254 51.916  1.00 56.65  ? 2169 HOH C O   1 
HETATM 8235 O O   . HOH N 3 .   ? -69.412  60.948 62.910  1.00 32.84  ? 2170 HOH C O   1 
HETATM 8236 O O   . HOH N 3 .   ? -66.078  46.974 61.781  1.00 42.08  ? 2171 HOH C O   1 
HETATM 8237 O O   . HOH N 3 .   ? -48.624  49.262 75.206  1.00 53.49  ? 2172 HOH C O   1 
HETATM 8238 O O   . HOH N 3 .   ? -41.126  69.997 47.948  1.00 44.10  ? 2173 HOH C O   1 
HETATM 8239 O O   . HOH N 3 .   ? -58.848  69.361 70.667  1.00 53.18  ? 2174 HOH C O   1 
HETATM 8240 O O   . HOH N 3 .   ? -55.442  59.744 42.639  1.00 52.47  ? 2175 HOH C O   1 
HETATM 8241 O O   . HOH N 3 .   ? -62.837  59.361 77.795  1.00 41.17  ? 2176 HOH C O   1 
HETATM 8242 O O   . HOH N 3 .   ? -57.546  71.548 68.871  1.00 51.31  ? 2177 HOH C O   1 
HETATM 8243 O O   . HOH N 3 .   ? -69.808  67.635 66.802  1.00 49.39  ? 2178 HOH C O   1 
HETATM 8244 O O   . HOH N 3 .   ? -48.984  58.790 45.414  1.00 45.71  ? 2179 HOH C O   1 
HETATM 8245 O O   . HOH N 3 .   ? -38.162  68.243 62.078  1.00 46.91  ? 2180 HOH C O   1 
HETATM 8246 O O   . HOH N 3 .   ? -74.430  50.845 83.769  1.00 45.31  ? 2181 HOH C O   1 
HETATM 8247 O O   . HOH N 3 .   ? -65.822  63.541 56.760  1.00 43.97  ? 2182 HOH C O   1 
HETATM 8248 O O   . HOH N 3 .   ? -58.909  65.137 49.899  1.00 56.89  ? 2183 HOH C O   1 
HETATM 8249 O O   . HOH N 3 .   ? -56.502  61.702 77.316  1.00 58.30  ? 2184 HOH C O   1 
HETATM 8250 O O   . HOH N 3 .   ? -69.766  67.488 59.221  1.00 44.84  ? 2185 HOH C O   1 
HETATM 8251 O O   . HOH N 3 .   ? -64.268  55.598 75.805  1.00 36.90  ? 2186 HOH C O   1 
HETATM 8252 O O   . HOH N 3 .   ? -64.879  43.952 57.931  1.00 51.58  ? 2187 HOH C O   1 
HETATM 8253 O O   . HOH N 3 .   ? -54.698  64.931 75.307  1.00 55.10  ? 2188 HOH C O   1 
HETATM 8254 O O   . HOH N 3 .   ? -47.058  55.291 72.203  1.00 40.74  ? 2189 HOH C O   1 
HETATM 8255 O O   . HOH N 3 .   ? -58.177  75.898 58.131  1.00 50.01  ? 2190 HOH C O   1 
HETATM 8256 O O   . HOH N 3 .   ? -51.101  74.782 67.951  1.00 54.53  ? 2191 HOH C O   1 
HETATM 8257 O O   . HOH N 3 .   ? -53.490  72.962 68.165  1.00 46.15  ? 2192 HOH C O   1 
HETATM 8258 O O   . HOH N 3 .   ? -52.304  70.769 72.369  1.00 55.64  ? 2193 HOH C O   1 
HETATM 8259 O O   . HOH N 3 .   ? -62.941  44.382 40.230  1.00 60.80  ? 2194 HOH C O   1 
HETATM 8260 O O   . HOH N 3 .   ? -68.176  52.043 83.847  1.00 45.84  ? 2195 HOH C O   1 
HETATM 8261 O O   . HOH N 3 .   ? -67.623  64.780 74.608  1.00 41.13  ? 2196 HOH C O   1 
HETATM 8262 O O   . HOH N 3 .   ? -51.483  41.564 62.754  1.00 50.04  ? 2197 HOH C O   1 
HETATM 8263 O O   . HOH N 3 .   ? -47.114  55.859 69.775  1.00 36.46  ? 2198 HOH C O   1 
HETATM 8264 O O   . HOH N 3 .   ? -63.317  65.824 53.432  1.00 44.51  ? 2199 HOH C O   1 
HETATM 8265 O O   . HOH N 3 .   ? -59.425  44.052 70.641  1.00 39.40  ? 2200 HOH C O   1 
HETATM 8266 O O   . HOH N 3 .   ? -52.622  38.882 47.333  1.00 66.21  ? 2201 HOH C O   1 
HETATM 8267 O O   . HOH N 3 .   ? -28.723  50.116 54.635  1.00 59.60  ? 2202 HOH C O   1 
HETATM 8268 O O   . HOH N 3 .   ? -38.709  43.629 65.628  1.00 52.00  ? 2203 HOH C O   1 
HETATM 8269 O O   . HOH N 3 .   ? -65.786  56.556 78.834  1.00 33.26  ? 2204 HOH C O   1 
HETATM 8270 O O   . HOH N 3 .   ? -67.978  64.954 56.104  1.00 37.66  ? 2205 HOH C O   1 
HETATM 8271 O O   . HOH N 3 .   ? -48.218  70.506 67.936  1.00 58.50  ? 2206 HOH C O   1 
HETATM 8272 O O   . HOH N 3 .   ? -67.961  73.993 60.591  1.00 54.52  ? 2207 HOH C O   1 
HETATM 8273 O O   . HOH N 3 .   ? -51.701  47.926 60.269  1.00 51.79  ? 2208 HOH C O   1 
HETATM 8274 O O   . HOH N 3 .   ? -58.701  54.109 42.979  1.00 38.61  ? 2209 HOH C O   1 
HETATM 8275 O O   . HOH N 3 .   ? -28.338  65.438 67.046  1.00 55.63  ? 2210 HOH C O   1 
HETATM 8276 O O   . HOH N 3 .   ? -57.231  64.149 75.365  1.00 40.18  ? 2211 HOH C O   1 
HETATM 8277 O O   . HOH N 3 .   ? -61.618  68.250 51.787  1.00 45.13  ? 2212 HOH C O   1 
HETATM 8278 O O   . HOH N 3 .   ? -59.946  69.017 67.815  1.00 35.09  ? 2213 HOH C O   1 
HETATM 8279 O O   . HOH N 3 .   ? -33.674  64.242 38.499  1.00 62.08  ? 2214 HOH C O   1 
HETATM 8280 O O   . HOH N 3 .   ? -37.116  72.791 53.351  1.00 53.61  ? 2215 HOH C O   1 
HETATM 8281 O O   . HOH N 3 .   ? -49.100  45.030 44.858  1.00 52.86  ? 2216 HOH C O   1 
HETATM 8282 O O   . HOH N 3 .   ? -50.206  73.505 44.411  1.00 48.43  ? 2217 HOH C O   1 
HETATM 8283 O O   . HOH N 3 .   ? -56.889  60.751 49.983  1.00 37.69  ? 2218 HOH C O   1 
HETATM 8284 O O   . HOH N 3 .   ? -30.924  64.426 53.522  1.00 54.85  ? 2219 HOH C O   1 
HETATM 8285 O O   . HOH N 3 .   ? -53.164  65.833 73.121  1.00 50.56  ? 2220 HOH C O   1 
HETATM 8286 O O   . HOH N 3 .   ? -64.004  66.874 68.999  1.00 55.41  ? 2221 HOH C O   1 
HETATM 8287 O O   . HOH N 3 .   ? -35.025  66.211 49.201  1.00 48.65  ? 2222 HOH C O   1 
HETATM 8288 O O   . HOH N 3 .   ? -72.135  48.445 57.337  1.00 54.18  ? 2223 HOH C O   1 
HETATM 8289 O O   . HOH N 3 .   ? -40.064  58.975 61.698  1.00 45.85  ? 2224 HOH C O   1 
HETATM 8290 O O   . HOH N 3 .   ? -49.520  52.828 74.936  1.00 56.23  ? 2225 HOH C O   1 
HETATM 8291 O O   . HOH N 3 .   ? -50.068  44.898 42.807  1.00 55.89  ? 2226 HOH C O   1 
HETATM 8292 O O   . HOH N 3 .   ? -47.621  60.884 75.953  1.00 60.42  ? 2227 HOH C O   1 
HETATM 8293 O O   . HOH N 3 .   ? -31.541  56.694 55.651  1.00 55.40  ? 2228 HOH C O   1 
HETATM 8294 O O   . HOH N 3 .   ? -59.830  44.331 42.176  1.00 57.80  ? 2229 HOH C O   1 
HETATM 8295 O O   . HOH N 3 .   ? -63.081  74.953 63.708  1.00 56.91  ? 2230 HOH C O   1 
HETATM 8296 O O   . HOH N 3 .   ? -60.033  49.990 73.955  1.00 53.49  ? 2231 HOH C O   1 
HETATM 8297 O O   . HOH N 3 .   ? -67.041  52.114 47.595  1.00 55.05  ? 2232 HOH C O   1 
HETATM 8298 O O   . HOH N 3 .   ? -57.516  40.816 59.162  1.00 60.92  ? 2233 HOH C O   1 
HETATM 8299 O O   . HOH N 3 .   ? -52.376  51.349 73.441  1.00 50.99  ? 2234 HOH C O   1 
HETATM 8300 O O   . HOH N 3 .   ? -69.177  47.213 87.260  1.00 53.47  ? 2235 HOH C O   1 
HETATM 8301 O O   . HOH N 3 .   ? -29.512  58.958 59.454  1.00 49.29  ? 2236 HOH C O   1 
HETATM 8302 O O   . HOH N 3 .   ? -36.104  67.948 37.261  1.00 67.14  ? 2237 HOH C O   1 
HETATM 8303 O O   . HOH N 3 .   ? -69.925  64.105 64.296  1.00 45.05  ? 2238 HOH C O   1 
HETATM 8304 O O   . HOH N 3 .   ? -49.025  62.415 37.462  1.00 59.65  ? 2239 HOH C O   1 
HETATM 8305 O O   . HOH N 3 .   ? -67.242  72.307 54.700  1.00 50.82  ? 2240 HOH C O   1 
HETATM 8306 O O   . HOH N 3 .   ? -55.518  57.017 73.895  1.00 36.65  ? 2241 HOH C O   1 
HETATM 8307 O O   . HOH N 3 .   ? -61.284  67.380 74.302  1.00 57.75  ? 2242 HOH C O   1 
HETATM 8308 O O   . HOH N 3 .   ? -49.500  55.254 73.979  1.00 45.10  ? 2243 HOH C O   1 
HETATM 8309 O O   . HOH N 3 .   ? -54.873  50.636 74.007  1.00 56.64  ? 2244 HOH C O   1 
HETATM 8310 O O   . HOH N 3 .   ? -58.408  63.829 78.341  1.00 63.47  ? 2245 HOH C O   1 
HETATM 8311 O O   . HOH N 3 .   ? -43.318  66.547 66.072  1.00 45.58  ? 2246 HOH C O   1 
HETATM 8312 O O   . HOH N 3 .   ? -75.035  53.481 84.275  1.00 54.50  ? 2247 HOH C O   1 
HETATM 8313 O O   . HOH N 3 .   ? -53.047  57.833 73.140  1.00 40.90  ? 2248 HOH C O   1 
HETATM 8314 O O   . HOH N 3 .   ? -69.802  65.160 66.758  1.00 46.07  ? 2249 HOH C O   1 
HETATM 8315 O O   . HOH N 3 .   ? -57.004  51.625 73.593  1.00 54.86  ? 2250 HOH C O   1 
HETATM 8316 O O   . HOH N 3 .   ? -63.398  59.858 80.212  1.00 55.77  ? 2251 HOH C O   1 
HETATM 8317 O O   . HOH N 3 .   ? -34.501  69.928 38.179  1.00 73.91  ? 2252 HOH C O   1 
HETATM 8318 O O   . HOH N 3 .   ? -67.736  64.869 79.853  1.00 59.35  ? 2253 HOH C O   1 
HETATM 8319 O O   . HOH N 3 .   ? -63.503  56.774 77.971  1.00 45.99  ? 2254 HOH C O   1 
HETATM 8320 O O   . HOH N 3 .   ? -67.168  56.272 83.083  1.00 56.88  ? 2255 HOH C O   1 
HETATM 8321 O O   . HOH N 3 .   ? -70.164  66.199 71.168  1.00 56.35  ? 2256 HOH C O   1 
HETATM 8322 O O   . HOH N 3 .   ? -59.567  62.820 51.340  1.00 53.42  ? 2257 HOH C O   1 
HETATM 8323 O O   . HOH N 3 .   ? -61.355  66.705 69.206  1.00 47.33  ? 2258 HOH C O   1 
HETATM 8324 O O   . HOH N 3 .   ? -70.383  63.200 74.124  1.00 39.29  ? 2259 HOH C O   1 
HETATM 8325 O O   . HOH N 3 .   ? -63.381  48.017 72.959  1.00 53.58  ? 2260 HOH C O   1 
HETATM 8326 O O   . HOH N 3 .   ? -60.887  53.351 77.364  1.00 37.70  ? 2261 HOH C O   1 
HETATM 8327 O O   . HOH N 3 .   ? -63.313  54.495 81.329  1.00 51.58  ? 2262 HOH C O   1 
HETATM 8328 O O   . HOH N 3 .   ? -58.501  54.630 76.305  1.00 35.16  ? 2263 HOH C O   1 
HETATM 8329 O O   . HOH N 3 .   ? -76.424  54.747 82.608  1.00 48.53  ? 2264 HOH C O   1 
HETATM 8330 O O   . HOH N 3 .   ? -68.780  65.617 77.440  1.00 55.40  ? 2265 HOH C O   1 
HETATM 8331 O O   . HOH N 3 .   ? -54.322  54.572 75.064  1.00 50.02  ? 2266 HOH C O   1 
HETATM 8332 O O   . HOH N 3 .   ? -56.632  57.898 76.108  1.00 51.95  ? 2267 HOH C O   1 
HETATM 8333 O O   . HOH N 3 .   ? -64.037  62.403 81.377  1.00 54.45  ? 2268 HOH C O   1 
HETATM 8334 O O   . HOH N 3 .   ? -63.368  71.069 69.450  1.00 57.62  ? 2269 HOH C O   1 
HETATM 8335 O O   . HOH O 3 .   ? -90.776  47.014 100.409 1.00 51.36  ? 2101 HOH D O   1 
HETATM 8336 O O   . HOH O 3 .   ? -96.382  52.797 94.579  1.00 51.50  ? 2102 HOH D O   1 
HETATM 8337 O O   . HOH O 3 .   ? -71.325  49.887 51.338  1.00 55.30  ? 2103 HOH D O   1 
HETATM 8338 O O   . HOH O 3 .   ? -82.710  52.575 87.508  1.00 58.48  ? 2104 HOH D O   1 
HETATM 8339 O O   . HOH O 3 .   ? -80.962  62.745 85.509  1.00 46.27  ? 2105 HOH D O   1 
HETATM 8340 O O   . HOH O 3 .   ? -93.495  24.757 73.679  1.00 71.59  ? 2106 HOH D O   1 
HETATM 8341 O O   . HOH O 3 .   ? -99.099  47.475 86.664  1.00 43.06  ? 2107 HOH D O   1 
HETATM 8342 O O   . HOH O 3 .   ? -86.247  23.076 80.067  1.00 58.87  ? 2108 HOH D O   1 
HETATM 8343 O O   . HOH O 3 .   ? -67.621  35.968 83.363  1.00 49.40  ? 2109 HOH D O   1 
HETATM 8344 O O   . HOH O 3 .   ? -101.060 39.985 103.681 1.00 50.85  ? 2110 HOH D O   1 
HETATM 8345 O O   . HOH O 3 .   ? -81.386  29.329 83.823  1.00 53.83  ? 2111 HOH D O   1 
HETATM 8346 O O   . HOH O 3 .   ? -77.414  44.196 89.561  1.00 55.06  ? 2112 HOH D O   1 
HETATM 8347 O O   . HOH O 3 .   ? -74.684  38.256 68.908  1.00 40.37  ? 2113 HOH D O   1 
HETATM 8348 O O   . HOH O 3 .   ? -70.564  43.788 84.105  1.00 42.65  ? 2114 HOH D O   1 
HETATM 8349 O O   . HOH O 3 .   ? -75.619  52.429 59.673  1.00 42.40  ? 2115 HOH D O   1 
HETATM 8350 O O   . HOH O 3 .   ? -91.479  31.014 63.424  1.00 55.54  ? 2116 HOH D O   1 
HETATM 8351 O O   . HOH O 3 .   ? -77.432  44.492 82.833  1.00 38.38  ? 2117 HOH D O   1 
HETATM 8352 O O   . HOH O 3 .   ? -83.836  37.354 69.362  1.00 54.30  ? 2118 HOH D O   1 
HETATM 8353 O O   . HOH O 3 .   ? -84.206  48.065 61.253  1.00 44.32  ? 2119 HOH D O   1 
HETATM 8354 O O   . HOH O 3 .   ? -84.322  28.688 78.052  1.00 55.94  ? 2120 HOH D O   1 
HETATM 8355 O O   . HOH O 3 .   ? -99.608  47.825 89.585  1.00 40.50  ? 2121 HOH D O   1 
HETATM 8356 O O   . HOH O 3 .   ? -81.152  59.304 88.232  1.00 55.73  ? 2122 HOH D O   1 
HETATM 8357 O O   . HOH O 3 .   ? -75.700  60.929 58.286  1.00 32.89  ? 2123 HOH D O   1 
HETATM 8358 O O   . HOH O 3 .   ? -83.436  40.137 88.643  1.00 45.22  ? 2124 HOH D O   1 
HETATM 8359 O O   . HOH O 3 .   ? -88.746  28.206 83.748  1.00 54.49  ? 2125 HOH D O   1 
HETATM 8360 O O   . HOH O 3 .   ? -80.125  37.730 72.546  1.00 38.84  ? 2126 HOH D O   1 
HETATM 8361 O O   . HOH O 3 .   ? -72.065  64.025 67.781  1.00 41.16  ? 2127 HOH D O   1 
HETATM 8362 O O   . HOH O 3 .   ? -69.356  45.455 67.465  1.00 38.55  ? 2128 HOH D O   1 
HETATM 8363 O O   . HOH O 3 .   ? -71.061  36.367 72.789  1.00 51.17  ? 2129 HOH D O   1 
HETATM 8364 O O   . HOH O 3 .   ? -95.705  50.921 73.144  1.00 37.59  ? 2130 HOH D O   1 
HETATM 8365 O O   . HOH O 3 .   ? -87.404  35.580 78.166  1.00 45.24  ? 2131 HOH D O   1 
HETATM 8366 O O   . HOH O 3 .   ? -101.299 55.514 85.111  1.00 55.82  ? 2132 HOH D O   1 
HETATM 8367 O O   . HOH O 3 .   ? -74.988  64.923 73.404  1.00 48.59  ? 2133 HOH D O   1 
HETATM 8368 O O   . HOH O 3 .   ? -89.296  43.728 95.788  1.00 47.21  ? 2134 HOH D O   1 
HETATM 8369 O O   . HOH O 3 .   ? -89.720  52.821 93.243  1.00 54.82  ? 2135 HOH D O   1 
HETATM 8370 O O   . HOH O 3 .   ? -85.724  39.346 76.958  1.00 34.73  ? 2136 HOH D O   1 
HETATM 8371 O O   . HOH O 3 .   ? -75.733  61.426 70.544  1.00 37.07  ? 2137 HOH D O   1 
HETATM 8372 O O   . HOH O 3 .   ? -80.898  26.259 80.585  1.00 58.76  ? 2138 HOH D O   1 
HETATM 8373 O O   . HOH O 3 .   ? -95.116  54.905 69.285  1.00 43.83  ? 2139 HOH D O   1 
HETATM 8374 O O   . HOH O 3 .   ? -71.568  62.582 63.206  1.00 36.66  ? 2140 HOH D O   1 
HETATM 8375 O O   . HOH O 3 .   ? -90.937  29.957 94.099  1.00 58.79  ? 2141 HOH D O   1 
HETATM 8376 O O   . HOH O 3 .   ? -66.877  47.396 69.195  1.00 43.31  ? 2142 HOH D O   1 
HETATM 8377 O O   . HOH O 3 .   ? -87.033  38.431 89.013  1.00 45.10  ? 2143 HOH D O   1 
HETATM 8378 O O   . HOH O 3 .   ? -77.710  59.389 59.690  1.00 37.42  ? 2144 HOH D O   1 
HETATM 8379 O O   . HOH O 3 .   ? -92.173  54.721 63.743  1.00 45.80  ? 2145 HOH D O   1 
HETATM 8380 O O   . HOH O 3 .   ? -98.167  49.402 98.590  1.00 47.46  ? 2146 HOH D O   1 
HETATM 8381 O O   . HOH O 3 .   ? -87.484  41.077 88.152  1.00 38.15  ? 2147 HOH D O   1 
HETATM 8382 O O   . HOH O 3 .   ? -80.247  57.869 67.497  1.00 29.54  ? 2148 HOH D O   1 
HETATM 8383 O O   . HOH O 3 .   ? -89.337  63.763 79.066  1.00 43.63  ? 2149 HOH D O   1 
HETATM 8384 O O   . HOH O 3 .   ? -79.376  50.993 60.947  1.00 35.57  ? 2150 HOH D O   1 
HETATM 8385 O O   . HOH O 3 .   ? -81.660  57.272 59.983  1.00 39.29  ? 2151 HOH D O   1 
HETATM 8386 O O   . HOH O 3 .   ? -76.525  40.059 61.933  1.00 51.26  ? 2152 HOH D O   1 
HETATM 8387 O O   . HOH O 3 .   ? -86.585  49.005 61.918  1.00 47.13  ? 2153 HOH D O   1 
HETATM 8388 O O   . HOH O 3 .   ? -84.116  31.899 79.369  1.00 51.18  ? 2154 HOH D O   1 
HETATM 8389 O O   . HOH O 3 .   ? -87.275  65.418 72.857  1.00 55.75  ? 2155 HOH D O   1 
HETATM 8390 O O   . HOH O 3 .   ? -75.711  60.502 81.842  1.00 40.08  ? 2156 HOH D O   1 
HETATM 8391 O O   . HOH O 3 .   ? -74.470  58.507 73.870  1.00 29.14  ? 2157 HOH D O   1 
HETATM 8392 O O   . HOH O 3 .   ? -89.556  57.327 65.515  1.00 35.24  ? 2158 HOH D O   1 
HETATM 8393 O O   . HOH O 3 .   ? -81.150  51.464 62.898  1.00 30.34  ? 2159 HOH D O   1 
HETATM 8394 O O   . HOH O 3 .   ? -73.695  50.279 60.542  1.00 40.62  ? 2160 HOH D O   1 
HETATM 8395 O O   . HOH O 3 .   ? -68.556  40.006 72.957  1.00 48.63  ? 2161 HOH D O   1 
HETATM 8396 O O   . HOH O 3 .   ? -94.168  59.185 90.352  1.00 57.05  ? 2162 HOH D O   1 
HETATM 8397 O O   . HOH O 3 .   ? -64.561  57.705 49.266  1.00 52.87  ? 2163 HOH D O   1 
HETATM 8398 O O   . HOH O 3 .   ? -92.432  36.325 74.688  1.00 53.02  ? 2164 HOH D O   1 
HETATM 8399 O O   . HOH O 3 .   ? -75.842  57.066 59.747  1.00 43.31  ? 2165 HOH D O   1 
HETATM 8400 O O   . HOH O 3 .   ? -90.040  40.695 87.391  1.00 35.53  ? 2166 HOH D O   1 
HETATM 8401 O O   . HOH O 3 .   ? -77.644  27.484 73.693  1.00 57.97  ? 2167 HOH D O   1 
HETATM 8402 O O   . HOH O 3 .   ? -90.071  45.856 64.138  1.00 40.05  ? 2168 HOH D O   1 
HETATM 8403 O O   . HOH O 3 .   ? -71.340  38.027 66.762  1.00 53.14  ? 2169 HOH D O   1 
HETATM 8404 O O   . HOH O 3 .   ? -103.445 42.198 86.134  1.00 47.55  ? 2170 HOH D O   1 
HETATM 8405 O O   . HOH O 3 .   ? -68.655  44.330 70.210  1.00 44.84  ? 2171 HOH D O   1 
HETATM 8406 O O   . HOH O 3 .   ? -99.423  49.267 84.163  1.00 41.28  ? 2172 HOH D O   1 
HETATM 8407 O O   . HOH O 3 .   ? -63.381  27.428 76.023  1.00 53.78  ? 2173 HOH D O   1 
HETATM 8408 O O   . HOH O 3 .   ? -90.111  29.339 91.556  1.00 57.62  ? 2174 HOH D O   1 
HETATM 8409 O O   . HOH O 3 .   ? -81.489  49.543 83.192  1.00 42.72  ? 2175 HOH D O   1 
HETATM 8410 O O   . HOH O 3 .   ? -81.913  58.627 69.513  1.00 32.93  ? 2176 HOH D O   1 
HETATM 8411 O O   . HOH O 3 .   ? -87.093  43.666 88.644  1.00 35.19  ? 2177 HOH D O   1 
HETATM 8412 O O   . HOH O 3 .   ? -69.997  57.868 51.638  1.00 40.72  ? 2178 HOH D O   1 
HETATM 8413 O O   . HOH O 3 .   ? -85.276  59.049 63.059  1.00 34.69  ? 2179 HOH D O   1 
HETATM 8414 O O   . HOH O 3 .   ? -66.650  37.687 91.374  1.00 45.43  ? 2180 HOH D O   1 
HETATM 8415 O O   . HOH O 3 .   ? -81.334  38.243 60.661  1.00 55.00  ? 2181 HOH D O   1 
HETATM 8416 O O   . HOH O 3 .   ? -80.583  61.736 59.218  1.00 32.97  ? 2182 HOH D O   1 
HETATM 8417 O O   . HOH O 3 .   ? -73.261  46.272 63.130  1.00 44.51  ? 2183 HOH D O   1 
HETATM 8418 O O   . HOH O 3 .   ? -72.207  35.754 69.884  1.00 57.67  ? 2184 HOH D O   1 
HETATM 8419 O O   . HOH O 3 .   ? -77.653  30.544 89.231  1.00 57.85  ? 2185 HOH D O   1 
HETATM 8420 O O   . HOH O 3 .   ? -85.939  51.601 62.787  1.00 41.44  ? 2186 HOH D O   1 
HETATM 8421 O O   . HOH O 3 .   ? -71.919  58.066 74.551  1.00 36.09  ? 2187 HOH D O   1 
HETATM 8422 O O   . HOH O 3 .   ? -76.319  64.235 65.146  1.00 34.75  ? 2188 HOH D O   1 
HETATM 8423 O O   . HOH O 3 .   ? -86.215  62.829 68.767  1.00 45.83  ? 2189 HOH D O   1 
HETATM 8424 O O   . HOH O 3 .   ? -101.464 60.903 74.863  1.00 44.32  ? 2190 HOH D O   1 
HETATM 8425 O O   . HOH O 3 .   ? -70.412  32.264 72.345  1.00 55.25  ? 2191 HOH D O   1 
HETATM 8426 O O   . HOH O 3 .   ? -74.321  58.623 57.650  1.00 37.48  ? 2192 HOH D O   1 
HETATM 8427 O O   . HOH O 3 .   ? -83.210  37.002 65.567  1.00 55.14  ? 2193 HOH D O   1 
HETATM 8428 O O   . HOH O 3 .   ? -87.900  63.683 71.618  1.00 49.33  ? 2194 HOH D O   1 
HETATM 8429 O O   . HOH O 3 .   ? -76.673  40.705 89.865  1.00 39.58  ? 2195 HOH D O   1 
HETATM 8430 O O   . HOH O 3 .   ? -83.809  66.502 77.511  1.00 53.06  ? 2196 HOH D O   1 
HETATM 8431 O O   . HOH O 3 .   ? -74.255  62.398 80.296  1.00 43.80  ? 2197 HOH D O   1 
HETATM 8432 O O   . HOH O 3 .   ? -92.508  61.789 67.333  1.00 46.87  ? 2198 HOH D O   1 
HETATM 8433 O O   . HOH O 3 .   ? -75.653  46.932 85.792  1.00 50.11  ? 2199 HOH D O   1 
HETATM 8434 O O   . HOH O 3 .   ? -74.460  57.949 82.225  1.00 37.32  ? 2200 HOH D O   1 
HETATM 8435 O O   . HOH O 3 .   ? -66.386  42.724 87.617  1.00 57.83  ? 2201 HOH D O   1 
HETATM 8436 O O   . HOH O 3 .   ? -81.070  56.950 86.689  1.00 43.38  ? 2202 HOH D O   1 
HETATM 8437 O O   . HOH O 3 .   ? -78.822  32.902 91.209  1.00 56.00  ? 2203 HOH D O   1 
HETATM 8438 O O   . HOH O 3 .   ? -70.811  33.435 86.996  1.00 45.12  ? 2204 HOH D O   1 
HETATM 8439 O O   . HOH O 3 .   ? -78.378  56.316 83.830  1.00 48.85  ? 2205 HOH D O   1 
HETATM 8440 O O   . HOH O 3 .   ? -84.426  61.996 71.847  1.00 39.16  ? 2206 HOH D O   1 
HETATM 8441 O O   . HOH O 3 .   ? -67.843  47.586 66.370  1.00 46.23  ? 2207 HOH D O   1 
HETATM 8442 O O   . HOH O 3 .   ? -63.685  35.445 82.353  1.00 54.85  ? 2208 HOH D O   1 
HETATM 8443 O O   . HOH O 3 .   ? -71.539  31.871 80.685  1.00 59.44  ? 2209 HOH D O   1 
HETATM 8444 O O   . HOH O 3 .   ? -92.830  45.405 64.148  1.00 52.62  ? 2210 HOH D O   1 
HETATM 8445 O O   . HOH O 3 .   ? -74.023  42.475 60.423  1.00 47.47  ? 2211 HOH D O   1 
HETATM 8446 O O   . HOH O 3 .   ? -93.782  33.208 72.003  1.00 62.66  ? 2212 HOH D O   1 
HETATM 8447 O O   . HOH O 3 .   ? -81.982  48.265 85.919  1.00 41.83  ? 2213 HOH D O   1 
HETATM 8448 O O   . HOH O 3 .   ? -75.495  56.277 80.875  1.00 44.95  ? 2214 HOH D O   1 
HETATM 8449 O O   . HOH O 3 .   ? -96.720  42.955 72.629  1.00 44.08  ? 2215 HOH D O   1 
HETATM 8450 O O   . HOH O 3 .   ? -92.387  37.240 97.680  1.00 61.32  ? 2216 HOH D O   1 
HETATM 8451 O O   . HOH O 3 .   ? -74.226  34.337 69.691  1.00 47.49  ? 2217 HOH D O   1 
HETATM 8452 O O   . HOH O 3 .   ? -79.489  33.626 66.315  1.00 51.84  ? 2218 HOH D O   1 
HETATM 8453 O O   . HOH O 3 .   ? -86.854  32.177 93.014  1.00 58.48  ? 2219 HOH D O   1 
HETATM 8454 O O   . HOH O 3 .   ? -73.310  66.562 60.273  1.00 45.84  ? 2220 HOH D O   1 
HETATM 8455 O O   . HOH O 3 .   ? -80.989  45.047 91.471  1.00 56.37  ? 2221 HOH D O   1 
HETATM 8456 O O   . HOH O 3 .   ? -85.319  66.428 80.179  1.00 60.48  ? 2222 HOH D O   1 
HETATM 8457 O O   . HOH O 3 .   ? -98.450  39.215 100.749 1.00 46.35  ? 2223 HOH D O   1 
HETATM 8458 O O   . HOH O 3 .   ? -81.085  63.256 66.853  1.00 48.16  ? 2224 HOH D O   1 
HETATM 8459 O O   . HOH O 3 .   ? -82.654  65.502 61.931  1.00 38.53  ? 2225 HOH D O   1 
HETATM 8460 O O   . HOH O 3 .   ? -79.905  62.648 70.638  1.00 51.27  ? 2226 HOH D O   1 
HETATM 8461 O O   . HOH O 3 .   ? -92.237  62.251 72.258  1.00 49.18  ? 2227 HOH D O   1 
HETATM 8462 O O   . HOH O 3 .   ? -95.590  58.287 71.433  1.00 52.81  ? 2228 HOH D O   1 
HETATM 8463 O O   . HOH O 3 .   ? -94.768  29.280 94.555  1.00 56.30  ? 2229 HOH D O   1 
HETATM 8464 O O   . HOH O 3 .   ? -92.510  53.387 94.658  1.00 55.40  ? 2230 HOH D O   1 
HETATM 8465 O O   . HOH O 3 .   ? -68.424  44.484 85.876  1.00 54.80  ? 2231 HOH D O   1 
HETATM 8466 O O   . HOH O 3 .   ? -83.423  40.178 60.692  1.00 53.01  ? 2232 HOH D O   1 
HETATM 8467 O O   . HOH O 3 .   ? -79.985  29.238 85.987  1.00 48.79  ? 2233 HOH D O   1 
HETATM 8468 O O   . HOH O 3 .   ? -98.174  40.359 73.481  1.00 48.80  ? 2234 HOH D O   1 
HETATM 8469 O O   . HOH O 3 .   ? -88.145  35.107 93.444  1.00 63.28  ? 2235 HOH D O   1 
HETATM 8470 O O   . HOH O 3 .   ? -101.233 50.483 92.212  1.00 60.32  ? 2236 HOH D O   1 
HETATM 8471 O O   . HOH O 3 .   ? -73.254  61.346 74.332  1.00 41.49  ? 2237 HOH D O   1 
HETATM 8472 O O   . HOH O 3 .   ? -96.786  60.112 86.392  1.00 58.53  ? 2238 HOH D O   1 
HETATM 8473 O O   . HOH O 3 .   ? -102.493 48.436 89.360  1.00 59.52  ? 2239 HOH D O   1 
HETATM 8474 O O   . HOH O 3 .   ? -89.990  64.803 65.314  1.00 48.25  ? 2240 HOH D O   1 
HETATM 8475 O O   . HOH O 3 .   ? -97.690  52.147 71.566  1.00 47.34  ? 2241 HOH D O   1 
HETATM 8476 O O   . HOH O 3 .   ? -72.622  33.885 93.186  1.00 55.18  ? 2242 HOH D O   1 
HETATM 8477 O O   . HOH O 3 .   ? -94.855  35.483 73.095  1.00 55.19  ? 2243 HOH D O   1 
HETATM 8478 O O   . HOH O 3 .   ? -76.264  48.370 59.403  1.00 57.86  ? 2244 HOH D O   1 
HETATM 8479 O O   . HOH O 3 .   ? -83.418  52.015 61.739  1.00 39.22  ? 2245 HOH D O   1 
HETATM 8480 O O   . HOH O 3 .   ? -65.263  61.790 52.153  1.00 58.45  ? 2246 HOH D O   1 
HETATM 8481 O O   . HOH O 3 .   ? -95.593  31.922 95.254  1.00 62.71  ? 2247 HOH D O   1 
HETATM 8482 O O   . HOH O 3 .   ? -95.030  52.047 97.059  1.00 62.38  ? 2248 HOH D O   1 
HETATM 8483 O O   . HOH O 3 .   ? -71.443  63.165 80.736  1.00 54.24  ? 2249 HOH D O   1 
HETATM 8484 O O   . HOH O 3 .   ? -74.235  36.336 93.890  1.00 60.83  ? 2250 HOH D O   1 
HETATM 8485 O O   . HOH O 3 .   ? -79.347  45.884 88.885  1.00 52.49  ? 2251 HOH D O   1 
HETATM 8486 O O   . HOH O 3 .   ? -95.596  61.897 88.396  1.00 64.24  ? 2252 HOH D O   1 
HETATM 8487 O O   . HOH O 3 .   ? -83.359  35.333 67.066  1.00 55.82  ? 2253 HOH D O   1 
HETATM 8488 O O   . HOH O 3 .   ? -85.362  31.573 76.885  1.00 50.41  ? 2254 HOH D O   1 
HETATM 8489 O O   . HOH O 3 .   ? -73.572  56.781 84.930  1.00 56.70  ? 2255 HOH D O   1 
HETATM 8490 O O   . HOH O 3 .   ? -82.760  37.403 71.902  1.00 45.01  ? 2256 HOH D O   1 
HETATM 8491 O O   . HOH O 3 .   ? -73.889  63.113 72.341  1.00 43.58  ? 2257 HOH D O   1 
HETATM 8492 O O   . HOH O 3 .   ? -73.833  65.598 68.985  1.00 52.52  ? 2258 HOH D O   1 
HETATM 8493 O O   . HOH O 3 .   ? -85.679  57.575 60.693  1.00 43.95  ? 2259 HOH D O   1 
HETATM 8494 O O   . HOH O 3 .   ? -80.372  48.375 59.517  1.00 62.10  ? 2260 HOH D O   1 
HETATM 8495 O O   . HOH O 3 .   ? -93.206  63.235 69.703  1.00 63.19  ? 2261 HOH D O   1 
HETATM 8496 O O   . HOH O 3 .   ? -88.041  35.572 75.581  1.00 59.72  ? 2262 HOH D O   1 
HETATM 8497 O O   . HOH O 3 .   ? -84.463  45.624 59.418  1.00 50.49  ? 2263 HOH D O   1 
HETATM 8498 O O   . HOH O 3 .   ? -73.348  64.227 65.237  1.00 41.97  ? 2264 HOH D O   1 
HETATM 8499 O O   . HOH O 3 .   ? -77.187  54.795 50.592  1.00 49.87  ? 2265 HOH D O   1 
HETATM 8500 O O   . HOH O 3 .   ? -77.474  52.725 57.649  1.00 47.09  ? 2266 HOH D O   1 
HETATM 8501 O O   . HOH O 3 .   ? -74.134  47.019 60.482  1.00 51.51  ? 2267 HOH D O   1 
HETATM 8502 O O   . HOH O 3 .   ? -79.890  52.506 58.810  1.00 40.22  ? 2268 HOH D O   1 
HETATM 8503 O O   . HOH O 3 .   ? -82.216  61.362 69.965  1.00 47.71  ? 2269 HOH D O   1 
HETATM 8504 O O   . HOH O 3 .   ? -70.060  41.212 58.208  1.00 69.33  ? 2270 HOH D O   1 
HETATM 8505 O O   . HOH O 3 .   ? -72.268  48.256 59.985  1.00 56.78  ? 2271 HOH D O   1 
HETATM 8506 O O   . HOH O 3 .   ? -100.101 56.486 87.465  1.00 55.08  ? 2272 HOH D O   1 
HETATM 8507 O O   . HOH O 3 .   ? -89.767  45.934 61.337  1.00 49.49  ? 2273 HOH D O   1 
HETATM 8508 O O   . HOH O 3 .   ? -81.746  54.614 59.388  1.00 45.55  ? 2274 HOH D O   1 
HETATM 8509 O O   . HOH O 3 .   ? -90.509  64.502 81.593  1.00 60.04  ? 2275 HOH D O   1 
HETATM 8510 O O   . HOH O 3 .   ? -76.438  55.387 58.153  1.00 51.27  ? 2276 HOH D O   1 
# 
