data_8ZEB
# 
_entry.id   8ZEB 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZEB         pdb_00008zeb 10.2210/pdb8zeb/pdb 
WWPDB D_1300047586 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-29 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZEB 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              dlwu@sdu.edu.cn 
_pdbx_contact_author.name_first         Dalei 
_pdbx_contact_author.name_last          WU 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1817-7229 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sun, X.N.' 1 0000-0003-0079-435X 
'Liu, J.X.' 2 0009-0002-8980-3477 
'Wu, D.L.'  3 0000-0003-1817-7229 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CN 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Sci China Chem' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1862-2771 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Biphenyl-Dihydrothiazole-Cyclized Peptide Libraries for Peptide Lig-and and Drug Discovery' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1007/s11426-024-2291-x 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Liu, J.J.'  1 ?                   
primary 'Sun, X.N.'  2 0000-0003-0079-435X 
primary 'Zhuang, J.' 3 ?                   
primary 'Liu, Z.Y.'  4 ?                   
primary 'Xu, C.Y.'   5 ?                   
primary 'Wu, D.L.'   6 0000-0003-1817-7229 
primary 'Wu, C.L.'   7 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Bcl-2-like protein 1'                                                16188.126 2   ? ? ? ? 
2 polymer syn 'THR-PRO-GLU-TRP-ALA-SER-THR-LEU-ARG-PRO-GLU-(CCS)-(EDN)-(Z7Z)-(PRS)' 1786.014  2   ? ? ? 
'TPEWASTLRPE(CCS)(EDN)(Z7Z)(PRS)' 
3 water   nat water                                                                 18.015    154 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Bcl2-L-1,Apoptosis regulator Bcl-X' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no  
;MSQSNRELVVDFLSYKLSQKGYSWSQPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGV
NWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
;
;MSQSNRELVVDFLSYKLSQKGYSWSQPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGV
NWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
;
A,B ? 
2 'polypeptide(L)' no yes 'TPEWASTLRPE(CCS)(EDN)(Z7Z)(PRS)' TPEWASTLRPECXXP D,C ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   SER n 
1 3   GLN n 
1 4   SER n 
1 5   ASN n 
1 6   ARG n 
1 7   GLU n 
1 8   LEU n 
1 9   VAL n 
1 10  VAL n 
1 11  ASP n 
1 12  PHE n 
1 13  LEU n 
1 14  SER n 
1 15  TYR n 
1 16  LYS n 
1 17  LEU n 
1 18  SER n 
1 19  GLN n 
1 20  LYS n 
1 21  GLY n 
1 22  TYR n 
1 23  SER n 
1 24  TRP n 
1 25  SER n 
1 26  GLN n 
1 27  PRO n 
1 28  MET n 
1 29  ALA n 
1 30  ALA n 
1 31  VAL n 
1 32  LYS n 
1 33  GLN n 
1 34  ALA n 
1 35  LEU n 
1 36  ARG n 
1 37  GLU n 
1 38  ALA n 
1 39  GLY n 
1 40  ASP n 
1 41  GLU n 
1 42  PHE n 
1 43  GLU n 
1 44  LEU n 
1 45  ARG n 
1 46  TYR n 
1 47  ARG n 
1 48  ARG n 
1 49  ALA n 
1 50  PHE n 
1 51  SER n 
1 52  ASP n 
1 53  LEU n 
1 54  THR n 
1 55  SER n 
1 56  GLN n 
1 57  LEU n 
1 58  HIS n 
1 59  ILE n 
1 60  THR n 
1 61  PRO n 
1 62  GLY n 
1 63  THR n 
1 64  ALA n 
1 65  TYR n 
1 66  GLN n 
1 67  SER n 
1 68  PHE n 
1 69  GLU n 
1 70  GLN n 
1 71  VAL n 
1 72  VAL n 
1 73  ASN n 
1 74  GLU n 
1 75  LEU n 
1 76  PHE n 
1 77  ARG n 
1 78  ASP n 
1 79  GLY n 
1 80  VAL n 
1 81  ASN n 
1 82  TRP n 
1 83  GLY n 
1 84  ARG n 
1 85  ILE n 
1 86  VAL n 
1 87  ALA n 
1 88  PHE n 
1 89  PHE n 
1 90  SER n 
1 91  PHE n 
1 92  GLY n 
1 93  GLY n 
1 94  ALA n 
1 95  LEU n 
1 96  CYS n 
1 97  VAL n 
1 98  GLU n 
1 99  SER n 
1 100 VAL n 
1 101 ASP n 
1 102 LYS n 
1 103 GLU n 
1 104 MET n 
1 105 GLN n 
1 106 VAL n 
1 107 LEU n 
1 108 VAL n 
1 109 SER n 
1 110 ARG n 
1 111 ILE n 
1 112 ALA n 
1 113 ALA n 
1 114 TRP n 
1 115 MET n 
1 116 ALA n 
1 117 THR n 
1 118 TYR n 
1 119 LEU n 
1 120 ASN n 
1 121 ASP n 
1 122 HIS n 
1 123 LEU n 
1 124 GLU n 
1 125 PRO n 
1 126 TRP n 
1 127 ILE n 
1 128 GLN n 
1 129 GLU n 
1 130 ASN n 
1 131 GLY n 
1 132 GLY n 
1 133 TRP n 
1 134 ASP n 
1 135 THR n 
1 136 PHE n 
1 137 VAL n 
1 138 GLU n 
1 139 LEU n 
1 140 TYR n 
1 141 GLY n 
2 1   THR n 
2 2   PRO n 
2 3   GLU n 
2 4   TRP n 
2 5   ALA n 
2 6   SER n 
2 7   THR n 
2 8   LEU n 
2 9   ARG n 
2 10  PRO n 
2 11  GLU n 
2 12  CCS n 
2 13  EDN n 
2 14  Z7Z n 
2 15  PRS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   141 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'BCL2L1, BCL2L, BCLX' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       15 
_pdbx_entity_src_syn.organism_scientific    'Phage 203' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       2048062 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                      ?               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                     ?               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                   ?               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'              ?               'C4 H7 N O4'     133.103 
CCS 'L-peptide linking' n 'CARBOXYMETHYLATED CYSTEINE' ?               'C5 H9 N O4 S'   179.194 
CYS 'L-peptide linking' y CYSTEINE                     ?               'C3 H7 N O2 S'   121.158 
EDN non-polymer         . ETHANE-1,2-DIAMINE           ETHYLENEDIAMINE 'C2 H8 N2'       60.098  
GLN 'L-peptide linking' y GLUTAMINE                    ?               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'              ?               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                      ?               'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                    ?               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                        ?               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                   ?               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                      ?               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                       ?               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                   ?               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                ?               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                      ?               'C5 H9 N O2'     115.130 
PRS 'L-peptide linking' n THIOPROLINE                  ?               'C4 H7 N O2 S'   133.169 
SER 'L-peptide linking' y SERINE                       ?               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                    ?               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                   ?               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                     ?               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                       ?               'C5 H11 N O2'    117.146 
Z7Z non-polymer         . 'biphenyl-4-carboxylic acid' ?               'C13 H10 O2'     198.217 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   SER 2   2   ?   ?   ?   A . n 
A 1 3   GLN 3   3   3   GLN GLN A . n 
A 1 4   SER 4   4   4   SER SER A . n 
A 1 5   ASN 5   5   5   ASN ASN A . n 
A 1 6   ARG 6   6   6   ARG ARG A . n 
A 1 7   GLU 7   7   7   GLU GLU A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   VAL 9   9   9   VAL VAL A . n 
A 1 10  VAL 10  10  10  VAL VAL A . n 
A 1 11  ASP 11  11  11  ASP ASP A . n 
A 1 12  PHE 12  12  12  PHE PHE A . n 
A 1 13  LEU 13  13  13  LEU LEU A . n 
A 1 14  SER 14  14  14  SER SER A . n 
A 1 15  TYR 15  15  15  TYR TYR A . n 
A 1 16  LYS 16  16  16  LYS LYS A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  SER 18  18  18  SER SER A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  LYS 20  20  20  LYS LYS A . n 
A 1 21  GLY 21  21  21  GLY GLY A . n 
A 1 22  TYR 22  22  22  TYR TYR A . n 
A 1 23  SER 23  23  23  SER SER A . n 
A 1 24  TRP 24  24  24  TRP TRP A . n 
A 1 25  SER 25  25  25  SER SER A . n 
A 1 26  GLN 26  26  26  GLN GLN A . n 
A 1 27  PRO 27  82  82  PRO PRO A . n 
A 1 28  MET 28  83  83  MET MET A . n 
A 1 29  ALA 29  84  84  ALA ALA A . n 
A 1 30  ALA 30  85  85  ALA ALA A . n 
A 1 31  VAL 31  86  86  VAL VAL A . n 
A 1 32  LYS 32  87  87  LYS LYS A . n 
A 1 33  GLN 33  88  88  GLN GLN A . n 
A 1 34  ALA 34  89  89  ALA ALA A . n 
A 1 35  LEU 35  90  90  LEU LEU A . n 
A 1 36  ARG 36  91  91  ARG ARG A . n 
A 1 37  GLU 37  92  92  GLU GLU A . n 
A 1 38  ALA 38  93  93  ALA ALA A . n 
A 1 39  GLY 39  94  94  GLY GLY A . n 
A 1 40  ASP 40  95  95  ASP ASP A . n 
A 1 41  GLU 41  96  96  GLU GLU A . n 
A 1 42  PHE 42  97  97  PHE PHE A . n 
A 1 43  GLU 43  98  98  GLU GLU A . n 
A 1 44  LEU 44  99  99  LEU LEU A . n 
A 1 45  ARG 45  100 100 ARG ARG A . n 
A 1 46  TYR 46  101 101 TYR TYR A . n 
A 1 47  ARG 47  102 102 ARG ARG A . n 
A 1 48  ARG 48  103 103 ARG ARG A . n 
A 1 49  ALA 49  104 104 ALA ALA A . n 
A 1 50  PHE 50  105 105 PHE PHE A . n 
A 1 51  SER 51  106 106 SER SER A . n 
A 1 52  ASP 52  107 107 ASP ASP A . n 
A 1 53  LEU 53  108 108 LEU LEU A . n 
A 1 54  THR 54  109 109 THR THR A . n 
A 1 55  SER 55  110 110 SER SER A . n 
A 1 56  GLN 56  111 111 GLN GLN A . n 
A 1 57  LEU 57  112 112 LEU LEU A . n 
A 1 58  HIS 58  113 113 HIS HIS A . n 
A 1 59  ILE 59  114 114 ILE ILE A . n 
A 1 60  THR 60  115 115 THR THR A . n 
A 1 61  PRO 61  116 116 PRO PRO A . n 
A 1 62  GLY 62  117 117 GLY GLY A . n 
A 1 63  THR 63  118 118 THR THR A . n 
A 1 64  ALA 64  119 119 ALA ALA A . n 
A 1 65  TYR 65  120 120 TYR TYR A . n 
A 1 66  GLN 66  121 121 GLN GLN A . n 
A 1 67  SER 67  122 122 SER SER A . n 
A 1 68  PHE 68  123 123 PHE PHE A . n 
A 1 69  GLU 69  124 124 GLU GLU A . n 
A 1 70  GLN 70  125 125 GLN GLN A . n 
A 1 71  VAL 71  126 126 VAL VAL A . n 
A 1 72  VAL 72  127 127 VAL VAL A . n 
A 1 73  ASN 73  128 128 ASN ASN A . n 
A 1 74  GLU 74  129 129 GLU GLU A . n 
A 1 75  LEU 75  130 130 LEU LEU A . n 
A 1 76  PHE 76  131 131 PHE PHE A . n 
A 1 77  ARG 77  132 132 ARG ARG A . n 
A 1 78  ASP 78  133 133 ASP ASP A . n 
A 1 79  GLY 79  134 134 GLY GLY A . n 
A 1 80  VAL 80  135 135 VAL VAL A . n 
A 1 81  ASN 81  136 136 ASN ASN A . n 
A 1 82  TRP 82  137 137 TRP TRP A . n 
A 1 83  GLY 83  138 138 GLY GLY A . n 
A 1 84  ARG 84  139 139 ARG ARG A . n 
A 1 85  ILE 85  140 140 ILE ILE A . n 
A 1 86  VAL 86  141 141 VAL VAL A . n 
A 1 87  ALA 87  142 142 ALA ALA A . n 
A 1 88  PHE 88  143 143 PHE PHE A . n 
A 1 89  PHE 89  144 144 PHE PHE A . n 
A 1 90  SER 90  145 145 SER SER A . n 
A 1 91  PHE 91  146 146 PHE PHE A . n 
A 1 92  GLY 92  147 147 GLY GLY A . n 
A 1 93  GLY 93  148 148 GLY GLY A . n 
A 1 94  ALA 94  149 149 ALA ALA A . n 
A 1 95  LEU 95  150 150 LEU LEU A . n 
A 1 96  CYS 96  151 151 CYS CYS A . n 
A 1 97  VAL 97  152 152 VAL VAL A . n 
A 1 98  GLU 98  153 153 GLU GLU A . n 
A 1 99  SER 99  154 154 SER SER A . n 
A 1 100 VAL 100 155 155 VAL VAL A . n 
A 1 101 ASP 101 156 156 ASP ASP A . n 
A 1 102 LYS 102 157 157 LYS LYS A . n 
A 1 103 GLU 103 158 158 GLU GLU A . n 
A 1 104 MET 104 159 159 MET MET A . n 
A 1 105 GLN 105 160 160 GLN GLN A . n 
A 1 106 VAL 106 161 161 VAL VAL A . n 
A 1 107 LEU 107 162 162 LEU LEU A . n 
A 1 108 VAL 108 163 163 VAL VAL A . n 
A 1 109 SER 109 164 164 SER SER A . n 
A 1 110 ARG 110 165 165 ARG ARG A . n 
A 1 111 ILE 111 166 166 ILE ILE A . n 
A 1 112 ALA 112 167 167 ALA ALA A . n 
A 1 113 ALA 113 168 168 ALA ALA A . n 
A 1 114 TRP 114 169 169 TRP TRP A . n 
A 1 115 MET 115 170 170 MET MET A . n 
A 1 116 ALA 116 171 171 ALA ALA A . n 
A 1 117 THR 117 172 172 THR THR A . n 
A 1 118 TYR 118 173 173 TYR TYR A . n 
A 1 119 LEU 119 174 174 LEU LEU A . n 
A 1 120 ASN 120 175 175 ASN ASN A . n 
A 1 121 ASP 121 176 176 ASP ASP A . n 
A 1 122 HIS 122 177 177 HIS HIS A . n 
A 1 123 LEU 123 178 178 LEU LEU A . n 
A 1 124 GLU 124 179 179 GLU GLU A . n 
A 1 125 PRO 125 180 180 PRO PRO A . n 
A 1 126 TRP 126 181 181 TRP TRP A . n 
A 1 127 ILE 127 182 182 ILE ILE A . n 
A 1 128 GLN 128 183 183 GLN GLN A . n 
A 1 129 GLU 129 184 184 GLU GLU A . n 
A 1 130 ASN 130 185 185 ASN ASN A . n 
A 1 131 GLY 131 186 186 GLY GLY A . n 
A 1 132 GLY 132 187 187 GLY GLY A . n 
A 1 133 TRP 133 188 188 TRP TRP A . n 
A 1 134 ASP 134 189 189 ASP ASP A . n 
A 1 135 THR 135 190 190 THR THR A . n 
A 1 136 PHE 136 191 191 PHE PHE A . n 
A 1 137 VAL 137 192 192 VAL VAL A . n 
A 1 138 GLU 138 193 193 GLU GLU A . n 
A 1 139 LEU 139 194 194 LEU LEU A . n 
A 1 140 TYR 140 195 195 TYR TYR A . n 
A 1 141 GLY 141 196 196 GLY GLY A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   SER 2   2   ?   ?   ?   B . n 
B 1 3   GLN 3   3   3   GLN GLN B . n 
B 1 4   SER 4   4   4   SER SER B . n 
B 1 5   ASN 5   5   5   ASN ASN B . n 
B 1 6   ARG 6   6   6   ARG ARG B . n 
B 1 7   GLU 7   7   7   GLU GLU B . n 
B 1 8   LEU 8   8   8   LEU LEU B . n 
B 1 9   VAL 9   9   9   VAL VAL B . n 
B 1 10  VAL 10  10  10  VAL VAL B . n 
B 1 11  ASP 11  11  11  ASP ASP B . n 
B 1 12  PHE 12  12  12  PHE PHE B . n 
B 1 13  LEU 13  13  13  LEU LEU B . n 
B 1 14  SER 14  14  14  SER SER B . n 
B 1 15  TYR 15  15  15  TYR TYR B . n 
B 1 16  LYS 16  16  16  LYS LYS B . n 
B 1 17  LEU 17  17  17  LEU LEU B . n 
B 1 18  SER 18  18  18  SER SER B . n 
B 1 19  GLN 19  19  19  GLN GLN B . n 
B 1 20  LYS 20  20  20  LYS LYS B . n 
B 1 21  GLY 21  21  21  GLY GLY B . n 
B 1 22  TYR 22  22  22  TYR TYR B . n 
B 1 23  SER 23  23  23  SER SER B . n 
B 1 24  TRP 24  24  24  TRP TRP B . n 
B 1 25  SER 25  25  25  SER SER B . n 
B 1 26  GLN 26  26  26  GLN GLN B . n 
B 1 27  PRO 27  82  82  PRO PRO B . n 
B 1 28  MET 28  83  83  MET MET B . n 
B 1 29  ALA 29  84  84  ALA ALA B . n 
B 1 30  ALA 30  85  85  ALA ALA B . n 
B 1 31  VAL 31  86  86  VAL VAL B . n 
B 1 32  LYS 32  87  87  LYS LYS B . n 
B 1 33  GLN 33  88  88  GLN GLN B . n 
B 1 34  ALA 34  89  89  ALA ALA B . n 
B 1 35  LEU 35  90  90  LEU LEU B . n 
B 1 36  ARG 36  91  91  ARG ARG B . n 
B 1 37  GLU 37  92  92  GLU GLU B . n 
B 1 38  ALA 38  93  93  ALA ALA B . n 
B 1 39  GLY 39  94  94  GLY GLY B . n 
B 1 40  ASP 40  95  95  ASP ASP B . n 
B 1 41  GLU 41  96  96  GLU GLU B . n 
B 1 42  PHE 42  97  97  PHE PHE B . n 
B 1 43  GLU 43  98  98  GLU GLU B . n 
B 1 44  LEU 44  99  99  LEU LEU B . n 
B 1 45  ARG 45  100 100 ARG ARG B . n 
B 1 46  TYR 46  101 101 TYR TYR B . n 
B 1 47  ARG 47  102 102 ARG ARG B . n 
B 1 48  ARG 48  103 103 ARG ARG B . n 
B 1 49  ALA 49  104 104 ALA ALA B . n 
B 1 50  PHE 50  105 105 PHE PHE B . n 
B 1 51  SER 51  106 106 SER SER B . n 
B 1 52  ASP 52  107 107 ASP ASP B . n 
B 1 53  LEU 53  108 108 LEU LEU B . n 
B 1 54  THR 54  109 109 THR THR B . n 
B 1 55  SER 55  110 110 SER SER B . n 
B 1 56  GLN 56  111 111 GLN GLN B . n 
B 1 57  LEU 57  112 112 LEU LEU B . n 
B 1 58  HIS 58  113 113 HIS HIS B . n 
B 1 59  ILE 59  114 114 ILE ILE B . n 
B 1 60  THR 60  115 115 THR THR B . n 
B 1 61  PRO 61  116 116 PRO PRO B . n 
B 1 62  GLY 62  117 117 GLY GLY B . n 
B 1 63  THR 63  118 118 THR THR B . n 
B 1 64  ALA 64  119 119 ALA ALA B . n 
B 1 65  TYR 65  120 120 TYR TYR B . n 
B 1 66  GLN 66  121 121 GLN GLN B . n 
B 1 67  SER 67  122 122 SER SER B . n 
B 1 68  PHE 68  123 123 PHE PHE B . n 
B 1 69  GLU 69  124 124 GLU GLU B . n 
B 1 70  GLN 70  125 125 GLN GLN B . n 
B 1 71  VAL 71  126 126 VAL VAL B . n 
B 1 72  VAL 72  127 127 VAL VAL B . n 
B 1 73  ASN 73  128 128 ASN ASN B . n 
B 1 74  GLU 74  129 129 GLU GLU B . n 
B 1 75  LEU 75  130 130 LEU LEU B . n 
B 1 76  PHE 76  131 131 PHE PHE B . n 
B 1 77  ARG 77  132 132 ARG ARG B . n 
B 1 78  ASP 78  133 133 ASP ASP B . n 
B 1 79  GLY 79  134 134 GLY GLY B . n 
B 1 80  VAL 80  135 135 VAL VAL B . n 
B 1 81  ASN 81  136 136 ASN ASN B . n 
B 1 82  TRP 82  137 137 TRP TRP B . n 
B 1 83  GLY 83  138 138 GLY GLY B . n 
B 1 84  ARG 84  139 139 ARG ARG B . n 
B 1 85  ILE 85  140 140 ILE ILE B . n 
B 1 86  VAL 86  141 141 VAL VAL B . n 
B 1 87  ALA 87  142 142 ALA ALA B . n 
B 1 88  PHE 88  143 143 PHE PHE B . n 
B 1 89  PHE 89  144 144 PHE PHE B . n 
B 1 90  SER 90  145 145 SER SER B . n 
B 1 91  PHE 91  146 146 PHE PHE B . n 
B 1 92  GLY 92  147 147 GLY GLY B . n 
B 1 93  GLY 93  148 148 GLY GLY B . n 
B 1 94  ALA 94  149 149 ALA ALA B . n 
B 1 95  LEU 95  150 150 LEU LEU B . n 
B 1 96  CYS 96  151 151 CYS CYS B . n 
B 1 97  VAL 97  152 152 VAL VAL B . n 
B 1 98  GLU 98  153 153 GLU GLU B . n 
B 1 99  SER 99  154 154 SER SER B . n 
B 1 100 VAL 100 155 155 VAL VAL B . n 
B 1 101 ASP 101 156 156 ASP ASP B . n 
B 1 102 LYS 102 157 157 LYS LYS B . n 
B 1 103 GLU 103 158 158 GLU GLU B . n 
B 1 104 MET 104 159 159 MET MET B . n 
B 1 105 GLN 105 160 160 GLN GLN B . n 
B 1 106 VAL 106 161 161 VAL VAL B . n 
B 1 107 LEU 107 162 162 LEU LEU B . n 
B 1 108 VAL 108 163 163 VAL VAL B . n 
B 1 109 SER 109 164 164 SER SER B . n 
B 1 110 ARG 110 165 165 ARG ARG B . n 
B 1 111 ILE 111 166 166 ILE ILE B . n 
B 1 112 ALA 112 167 167 ALA ALA B . n 
B 1 113 ALA 113 168 168 ALA ALA B . n 
B 1 114 TRP 114 169 169 TRP TRP B . n 
B 1 115 MET 115 170 170 MET MET B . n 
B 1 116 ALA 116 171 171 ALA ALA B . n 
B 1 117 THR 117 172 172 THR THR B . n 
B 1 118 TYR 118 173 173 TYR TYR B . n 
B 1 119 LEU 119 174 174 LEU LEU B . n 
B 1 120 ASN 120 175 175 ASN ASN B . n 
B 1 121 ASP 121 176 176 ASP ASP B . n 
B 1 122 HIS 122 177 177 HIS HIS B . n 
B 1 123 LEU 123 178 178 LEU LEU B . n 
B 1 124 GLU 124 179 179 GLU GLU B . n 
B 1 125 PRO 125 180 180 PRO PRO B . n 
B 1 126 TRP 126 181 181 TRP TRP B . n 
B 1 127 ILE 127 182 182 ILE ILE B . n 
B 1 128 GLN 128 183 183 GLN GLN B . n 
B 1 129 GLU 129 184 184 GLU GLU B . n 
B 1 130 ASN 130 185 185 ASN ASN B . n 
B 1 131 GLY 131 186 186 GLY GLY B . n 
B 1 132 GLY 132 187 187 GLY GLY B . n 
B 1 133 TRP 133 188 188 TRP TRP B . n 
B 1 134 ASP 134 189 189 ASP ASP B . n 
B 1 135 THR 135 190 190 THR THR B . n 
B 1 136 PHE 136 191 191 PHE PHE B . n 
B 1 137 VAL 137 192 192 VAL VAL B . n 
B 1 138 GLU 138 193 193 GLU GLU B . n 
B 1 139 LEU 139 194 194 LEU LEU B . n 
B 1 140 TYR 140 195 195 TYR TYR B . n 
B 1 141 GLY 141 196 196 GLY GLY B . n 
C 2 1   THR 1   1   2   THR THR D . n 
C 2 2   PRO 2   2   3   PRO PRO D . n 
C 2 3   GLU 3   3   4   GLU GLU D . n 
C 2 4   TRP 4   4   5   TRP TRP D . n 
C 2 5   ALA 5   5   6   ALA ALA D . n 
C 2 6   SER 6   6   7   SER SER D . n 
C 2 7   THR 7   7   8   THR THR D . n 
C 2 8   LEU 8   8   9   LEU LEU D . n 
C 2 9   ARG 9   9   10  ARG ARG D . n 
C 2 10  PRO 10  10  11  PRO PRO D . n 
C 2 11  GLU 11  11  12  GLU GLU D . n 
C 2 12  CCS 12  12  13  CCS LIG D . n 
C 2 13  EDN 13  13  13  EDN LIG D . n 
C 2 14  Z7Z 14  14  13  Z7Z LIG D . n 
C 2 15  PRS 15  15  13  PRS LIG D . n 
D 2 1   THR 1   1   2   THR THR C . n 
D 2 2   PRO 2   2   3   PRO PRO C . n 
D 2 3   GLU 3   3   4   GLU GLU C . n 
D 2 4   TRP 4   4   5   TRP TRP C . n 
D 2 5   ALA 5   5   6   ALA ALA C . n 
D 2 6   SER 6   6   7   SER SER C . n 
D 2 7   THR 7   7   8   THR THR C . n 
D 2 8   LEU 8   8   9   LEU LEU C . n 
D 2 9   ARG 9   9   10  ARG ARG C . n 
D 2 10  PRO 10  10  11  PRO PRO C . n 
D 2 11  GLU 11  11  12  GLU GLU C . n 
D 2 12  CCS 12  12  13  CCS LIG C . n 
D 2 13  EDN 13  13  13  EDN LIG C . n 
D 2 14  Z7Z 14  14  13  Z7Z LIG C . n 
D 2 15  PRS 15  15  13  PRS LIG C . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 PRS ? ? PRS ? ? 'SUBJECT OF INVESTIGATION' ? 
2 EDN ? ? EDN ? ? 'SUBJECT OF INVESTIGATION' ? 
3 Z7Z ? ? Z7Z ? ? 'SUBJECT OF INVESTIGATION' ? 
4 CCS ? ? CCS ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 HOH 1  201 127 HOH HOH A . 
E 3 HOH 2  202 108 HOH HOH A . 
E 3 HOH 3  203 33  HOH HOH A . 
E 3 HOH 4  204 124 HOH HOH A . 
E 3 HOH 5  205 74  HOH HOH A . 
E 3 HOH 6  206 138 HOH HOH A . 
E 3 HOH 7  207 58  HOH HOH A . 
E 3 HOH 8  208 152 HOH HOH A . 
E 3 HOH 9  209 25  HOH HOH A . 
E 3 HOH 10 210 60  HOH HOH A . 
E 3 HOH 11 211 51  HOH HOH A . 
E 3 HOH 12 212 27  HOH HOH A . 
E 3 HOH 13 213 75  HOH HOH A . 
E 3 HOH 14 214 44  HOH HOH A . 
E 3 HOH 15 215 8   HOH HOH A . 
E 3 HOH 16 216 22  HOH HOH A . 
E 3 HOH 17 217 28  HOH HOH A . 
E 3 HOH 18 218 109 HOH HOH A . 
E 3 HOH 19 219 38  HOH HOH A . 
E 3 HOH 20 220 10  HOH HOH A . 
E 3 HOH 21 221 46  HOH HOH A . 
E 3 HOH 22 222 121 HOH HOH A . 
E 3 HOH 23 223 98  HOH HOH A . 
E 3 HOH 24 224 54  HOH HOH A . 
E 3 HOH 25 225 37  HOH HOH A . 
E 3 HOH 26 226 29  HOH HOH A . 
E 3 HOH 27 227 93  HOH HOH A . 
E 3 HOH 28 228 56  HOH HOH A . 
E 3 HOH 29 229 89  HOH HOH A . 
E 3 HOH 30 230 94  HOH HOH A . 
E 3 HOH 31 231 35  HOH HOH A . 
E 3 HOH 32 232 1   HOH HOH A . 
E 3 HOH 33 233 16  HOH HOH A . 
E 3 HOH 34 234 71  HOH HOH A . 
E 3 HOH 35 235 92  HOH HOH A . 
E 3 HOH 36 236 23  HOH HOH A . 
E 3 HOH 37 237 87  HOH HOH A . 
E 3 HOH 38 238 14  HOH HOH A . 
E 3 HOH 39 239 78  HOH HOH A . 
E 3 HOH 40 240 47  HOH HOH A . 
E 3 HOH 41 241 32  HOH HOH A . 
E 3 HOH 42 242 2   HOH HOH A . 
E 3 HOH 43 243 82  HOH HOH A . 
E 3 HOH 44 244 126 HOH HOH A . 
E 3 HOH 45 245 142 HOH HOH A . 
E 3 HOH 46 246 3   HOH HOH A . 
E 3 HOH 47 247 42  HOH HOH A . 
E 3 HOH 48 248 111 HOH HOH A . 
E 3 HOH 49 249 52  HOH HOH A . 
E 3 HOH 50 250 137 HOH HOH A . 
E 3 HOH 51 251 118 HOH HOH A . 
E 3 HOH 52 252 141 HOH HOH A . 
E 3 HOH 53 253 24  HOH HOH A . 
E 3 HOH 54 254 143 HOH HOH A . 
E 3 HOH 55 255 115 HOH HOH A . 
E 3 HOH 56 256 125 HOH HOH A . 
E 3 HOH 57 257 39  HOH HOH A . 
E 3 HOH 58 258 9   HOH HOH A . 
E 3 HOH 59 259 85  HOH HOH A . 
E 3 HOH 60 260 122 HOH HOH A . 
E 3 HOH 61 261 157 HOH HOH A . 
E 3 HOH 62 262 151 HOH HOH A . 
E 3 HOH 63 263 99  HOH HOH A . 
E 3 HOH 64 264 158 HOH HOH A . 
E 3 HOH 65 265 100 HOH HOH A . 
E 3 HOH 66 266 105 HOH HOH A . 
E 3 HOH 67 267 55  HOH HOH A . 
E 3 HOH 68 268 13  HOH HOH A . 
E 3 HOH 69 269 77  HOH HOH A . 
E 3 HOH 70 270 106 HOH HOH A . 
E 3 HOH 71 271 113 HOH HOH A . 
E 3 HOH 72 272 135 HOH HOH A . 
E 3 HOH 73 273 153 HOH HOH A . 
E 3 HOH 74 274 132 HOH HOH A . 
E 3 HOH 75 275 119 HOH HOH A . 
E 3 HOH 76 276 103 HOH HOH A . 
E 3 HOH 77 277 76  HOH HOH A . 
E 3 HOH 78 278 117 HOH HOH A . 
E 3 HOH 79 279 144 HOH HOH A . 
E 3 HOH 80 280 104 HOH HOH A . 
E 3 HOH 81 281 11  HOH HOH A . 
E 3 HOH 82 282 128 HOH HOH A . 
E 3 HOH 83 283 154 HOH HOH A . 
E 3 HOH 84 284 84  HOH HOH A . 
E 3 HOH 85 285 80  HOH HOH A . 
E 3 HOH 86 286 120 HOH HOH A . 
E 3 HOH 87 287 18  HOH HOH A . 
E 3 HOH 88 288 112 HOH HOH A . 
F 3 HOH 1  201 145 HOH HOH B . 
F 3 HOH 2  202 70  HOH HOH B . 
F 3 HOH 3  203 57  HOH HOH B . 
F 3 HOH 4  204 15  HOH HOH B . 
F 3 HOH 5  205 7   HOH HOH B . 
F 3 HOH 6  206 49  HOH HOH B . 
F 3 HOH 7  207 95  HOH HOH B . 
F 3 HOH 8  208 149 HOH HOH B . 
F 3 HOH 9  209 50  HOH HOH B . 
F 3 HOH 10 210 90  HOH HOH B . 
F 3 HOH 11 211 150 HOH HOH B . 
F 3 HOH 12 212 148 HOH HOH B . 
F 3 HOH 13 213 64  HOH HOH B . 
F 3 HOH 14 214 48  HOH HOH B . 
F 3 HOH 15 215 19  HOH HOH B . 
F 3 HOH 16 216 45  HOH HOH B . 
F 3 HOH 17 217 61  HOH HOH B . 
F 3 HOH 18 218 53  HOH HOH B . 
F 3 HOH 19 219 41  HOH HOH B . 
F 3 HOH 20 220 116 HOH HOH B . 
F 3 HOH 21 221 107 HOH HOH B . 
F 3 HOH 22 222 66  HOH HOH B . 
F 3 HOH 23 223 34  HOH HOH B . 
F 3 HOH 24 224 129 HOH HOH B . 
F 3 HOH 25 225 97  HOH HOH B . 
F 3 HOH 26 226 62  HOH HOH B . 
F 3 HOH 27 227 43  HOH HOH B . 
F 3 HOH 28 228 79  HOH HOH B . 
F 3 HOH 29 229 5   HOH HOH B . 
F 3 HOH 30 230 30  HOH HOH B . 
F 3 HOH 31 231 4   HOH HOH B . 
F 3 HOH 32 232 26  HOH HOH B . 
F 3 HOH 33 233 72  HOH HOH B . 
F 3 HOH 34 234 68  HOH HOH B . 
F 3 HOH 35 235 6   HOH HOH B . 
F 3 HOH 36 236 31  HOH HOH B . 
F 3 HOH 37 237 83  HOH HOH B . 
F 3 HOH 38 238 40  HOH HOH B . 
F 3 HOH 39 239 59  HOH HOH B . 
F 3 HOH 40 240 155 HOH HOH B . 
F 3 HOH 41 241 136 HOH HOH B . 
F 3 HOH 42 242 114 HOH HOH B . 
F 3 HOH 43 243 130 HOH HOH B . 
F 3 HOH 44 244 147 HOH HOH B . 
F 3 HOH 45 245 20  HOH HOH B . 
F 3 HOH 46 246 88  HOH HOH B . 
F 3 HOH 47 247 63  HOH HOH B . 
F 3 HOH 48 248 91  HOH HOH B . 
F 3 HOH 49 249 86  HOH HOH B . 
F 3 HOH 50 250 96  HOH HOH B . 
F 3 HOH 51 251 131 HOH HOH B . 
F 3 HOH 52 252 69  HOH HOH B . 
F 3 HOH 53 253 81  HOH HOH B . 
F 3 HOH 54 254 67  HOH HOH B . 
F 3 HOH 55 255 159 HOH HOH B . 
F 3 HOH 56 256 156 HOH HOH B . 
F 3 HOH 57 257 133 HOH HOH B . 
G 3 HOH 1  101 12  HOH HOH D . 
G 3 HOH 2  102 65  HOH HOH D . 
G 3 HOH 3  103 36  HOH HOH D . 
G 3 HOH 4  104 134 HOH HOH D . 
G 3 HOH 5  105 73  HOH HOH D . 
H 3 HOH 1  101 17  HOH HOH C . 
H 3 HOH 2  102 21  HOH HOH C . 
H 3 HOH 3  103 110 HOH HOH C . 
H 3 HOH 4  104 146 HOH HOH C . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.13_2998 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.13_2998 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .         5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZEB 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     64.022 
_cell.length_a_esd                 ? 
_cell.length_b                     97.605 
_cell.length_b_esd                 ? 
_cell.length_c                     93.149 
_cell.length_c_esd                 ? 
_cell.volume                       582075.741 
_cell.volume_esd                   ? 
_cell.Z_PDB                        16 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZEB 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                20 
_symmetry.space_group_name_Hall            'C 2c 2' 
_symmetry.space_group_name_H-M             'C 2 2 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZEB 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.02 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          39.23 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          EVAPORATION 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'15% v/v 2-Propanol, 0.1 M Sodium citrate tribasic dihydrate pH 5.0, 10% w/v Polyethylene glycol 10,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-24 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97904 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL10U2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97904 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL10U2 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          25.96 
_reflns.entry_id                                       8ZEB 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.837 
_reflns.d_resolution_low                               53.606 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     21539 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.1 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.000 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.837 
_reflns_shell.d_res_low                                     2.036 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3017 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.996 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               30.83 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZEB 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.95 
_refine.ls_d_res_low                             48.80 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     21532 
_refine.ls_number_reflns_R_free                  1069 
_refine.ls_number_reflns_R_work                  20463 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.20 
_refine.ls_percent_reflns_R_free                 4.96 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1832 
_refine.ls_R_factor_R_free                       0.2257 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1809 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      7YAA 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.4274 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1858 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.95 
_refine_hist.d_res_low                        48.80 
_refine_hist.number_atoms_solvent             154 
_refine_hist.number_atoms_total               2660 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2506 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0080 ? 2582 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8682 ? 3509 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0475 ? 359  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0057 ? 455  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 7.0530 ? 1773 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.95 2.04  . . 131 2376 94.11  . . . . 0.2475 . . . . . . . . . . . 0.2895 
'X-RAY DIFFRACTION' 2.04 2.14  . . 127 2543 99.66  . . . . 0.2100 . . . . . . . . . . . 0.2714 
'X-RAY DIFFRACTION' 2.14 2.28  . . 132 2532 99.89  . . . . 0.1990 . . . . . . . . . . . 0.2896 
'X-RAY DIFFRACTION' 2.28 2.45  . . 123 2587 100.00 . . . . 0.1885 . . . . . . . . . . . 0.2620 
'X-RAY DIFFRACTION' 2.45 2.70  . . 139 2539 100.00 . . . . 0.1832 . . . . . . . . . . . 0.2171 
'X-RAY DIFFRACTION' 2.70 3.09  . . 146 2575 100.00 . . . . 0.1877 . . . . . . . . . . . 0.2268 
'X-RAY DIFFRACTION' 3.09 3.90  . . 134 2603 100.00 . . . . 0.1673 . . . . . . . . . . . 0.2174 
'X-RAY DIFFRACTION' 3.90 48.80 . . 137 2708 99.93  . . . . 0.1646 . . . . . . . . . . . 0.1926 
# 
_struct.entry_id                     8ZEB 
_struct.title                        'Crystal structure of BCL-XL bound by cp-B6X-4' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZEB 
_struct_keywords.text            'BCL-XL, CYCLIC PEPTIDE, APOPTOSIS' 
_struct_keywords.pdbx_keywords   APOPTOSIS 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP B2CL1_HUMAN Q07817 ? 1 
;MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREV
IPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQ
VLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
;
1 
2 PDB 8ZEB        8ZEB   ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZEB A 1 ? 141 ? Q07817 1 ? 196 ? 1 196 
2 1 8ZEB B 1 ? 141 ? Q07817 1 ? 196 ? 1 196 
3 2 8ZEB D 1 ? 15  ? 8ZEB   1 ? 15  ? 1 15  
4 2 8ZEB C 1 ? 15  ? 8ZEB   1 ? 15  ? 1 15  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZEB ? A ? ? UNP Q07817 PHE 27 deletion ? 1   
1 8ZEB ? A ? ? UNP Q07817 SER 28 deletion ? 2   
1 8ZEB ? A ? ? UNP Q07817 ASP 29 deletion ? 3   
1 8ZEB ? A ? ? UNP Q07817 VAL 30 deletion ? 4   
1 8ZEB ? A ? ? UNP Q07817 GLU 31 deletion ? 5   
1 8ZEB ? A ? ? UNP Q07817 GLU 32 deletion ? 6   
1 8ZEB ? A ? ? UNP Q07817 ASN 33 deletion ? 7   
1 8ZEB ? A ? ? UNP Q07817 ARG 34 deletion ? 8   
1 8ZEB ? A ? ? UNP Q07817 THR 35 deletion ? 9   
1 8ZEB ? A ? ? UNP Q07817 GLU 36 deletion ? 10  
1 8ZEB ? A ? ? UNP Q07817 ALA 37 deletion ? 11  
1 8ZEB ? A ? ? UNP Q07817 PRO 38 deletion ? 12  
1 8ZEB ? A ? ? UNP Q07817 GLU 39 deletion ? 13  
1 8ZEB ? A ? ? UNP Q07817 GLY 40 deletion ? 14  
1 8ZEB ? A ? ? UNP Q07817 THR 41 deletion ? 15  
1 8ZEB ? A ? ? UNP Q07817 GLU 42 deletion ? 16  
1 8ZEB ? A ? ? UNP Q07817 SER 43 deletion ? 17  
1 8ZEB ? A ? ? UNP Q07817 GLU 44 deletion ? 18  
1 8ZEB ? A ? ? UNP Q07817 MET 45 deletion ? 19  
1 8ZEB ? A ? ? UNP Q07817 GLU 46 deletion ? 20  
1 8ZEB ? A ? ? UNP Q07817 THR 47 deletion ? 21  
1 8ZEB ? A ? ? UNP Q07817 PRO 48 deletion ? 22  
1 8ZEB ? A ? ? UNP Q07817 SER 49 deletion ? 23  
1 8ZEB ? A ? ? UNP Q07817 ALA 50 deletion ? 24  
1 8ZEB ? A ? ? UNP Q07817 ILE 51 deletion ? 25  
1 8ZEB ? A ? ? UNP Q07817 ASN 52 deletion ? 26  
1 8ZEB ? A ? ? UNP Q07817 GLY 53 deletion ? 27  
1 8ZEB ? A ? ? UNP Q07817 ASN 54 deletion ? 28  
1 8ZEB ? A ? ? UNP Q07817 PRO 55 deletion ? 29  
1 8ZEB ? A ? ? UNP Q07817 SER 56 deletion ? 30  
1 8ZEB ? A ? ? UNP Q07817 TRP 57 deletion ? 31  
1 8ZEB ? A ? ? UNP Q07817 HIS 58 deletion ? 32  
1 8ZEB ? A ? ? UNP Q07817 LEU 59 deletion ? 33  
1 8ZEB ? A ? ? UNP Q07817 ALA 60 deletion ? 34  
1 8ZEB ? A ? ? UNP Q07817 ASP 61 deletion ? 35  
1 8ZEB ? A ? ? UNP Q07817 SER 62 deletion ? 36  
1 8ZEB ? A ? ? UNP Q07817 PRO 63 deletion ? 37  
1 8ZEB ? A ? ? UNP Q07817 ALA 64 deletion ? 38  
1 8ZEB ? A ? ? UNP Q07817 VAL 65 deletion ? 39  
1 8ZEB ? A ? ? UNP Q07817 ASN 66 deletion ? 40  
1 8ZEB ? A ? ? UNP Q07817 GLY 67 deletion ? 41  
1 8ZEB ? A ? ? UNP Q07817 ALA 68 deletion ? 42  
1 8ZEB ? A ? ? UNP Q07817 THR 69 deletion ? 43  
1 8ZEB ? A ? ? UNP Q07817 GLY 70 deletion ? 44  
1 8ZEB ? A ? ? UNP Q07817 HIS 71 deletion ? 45  
1 8ZEB ? A ? ? UNP Q07817 SER 72 deletion ? 46  
1 8ZEB ? A ? ? UNP Q07817 SER 73 deletion ? 47  
1 8ZEB ? A ? ? UNP Q07817 SER 74 deletion ? 48  
1 8ZEB ? A ? ? UNP Q07817 LEU 75 deletion ? 49  
1 8ZEB ? A ? ? UNP Q07817 ASP 76 deletion ? 50  
1 8ZEB ? A ? ? UNP Q07817 ALA 77 deletion ? 51  
1 8ZEB ? A ? ? UNP Q07817 ARG 78 deletion ? 52  
1 8ZEB ? A ? ? UNP Q07817 GLU 79 deletion ? 53  
1 8ZEB ? A ? ? UNP Q07817 VAL 80 deletion ? 54  
1 8ZEB ? A ? ? UNP Q07817 ILE 81 deletion ? 55  
2 8ZEB ? B ? ? UNP Q07817 PHE 27 deletion ? 56  
2 8ZEB ? B ? ? UNP Q07817 SER 28 deletion ? 57  
2 8ZEB ? B ? ? UNP Q07817 ASP 29 deletion ? 58  
2 8ZEB ? B ? ? UNP Q07817 VAL 30 deletion ? 59  
2 8ZEB ? B ? ? UNP Q07817 GLU 31 deletion ? 60  
2 8ZEB ? B ? ? UNP Q07817 GLU 32 deletion ? 61  
2 8ZEB ? B ? ? UNP Q07817 ASN 33 deletion ? 62  
2 8ZEB ? B ? ? UNP Q07817 ARG 34 deletion ? 63  
2 8ZEB ? B ? ? UNP Q07817 THR 35 deletion ? 64  
2 8ZEB ? B ? ? UNP Q07817 GLU 36 deletion ? 65  
2 8ZEB ? B ? ? UNP Q07817 ALA 37 deletion ? 66  
2 8ZEB ? B ? ? UNP Q07817 PRO 38 deletion ? 67  
2 8ZEB ? B ? ? UNP Q07817 GLU 39 deletion ? 68  
2 8ZEB ? B ? ? UNP Q07817 GLY 40 deletion ? 69  
2 8ZEB ? B ? ? UNP Q07817 THR 41 deletion ? 70  
2 8ZEB ? B ? ? UNP Q07817 GLU 42 deletion ? 71  
2 8ZEB ? B ? ? UNP Q07817 SER 43 deletion ? 72  
2 8ZEB ? B ? ? UNP Q07817 GLU 44 deletion ? 73  
2 8ZEB ? B ? ? UNP Q07817 MET 45 deletion ? 74  
2 8ZEB ? B ? ? UNP Q07817 GLU 46 deletion ? 75  
2 8ZEB ? B ? ? UNP Q07817 THR 47 deletion ? 76  
2 8ZEB ? B ? ? UNP Q07817 PRO 48 deletion ? 77  
2 8ZEB ? B ? ? UNP Q07817 SER 49 deletion ? 78  
2 8ZEB ? B ? ? UNP Q07817 ALA 50 deletion ? 79  
2 8ZEB ? B ? ? UNP Q07817 ILE 51 deletion ? 80  
2 8ZEB ? B ? ? UNP Q07817 ASN 52 deletion ? 81  
2 8ZEB ? B ? ? UNP Q07817 GLY 53 deletion ? 82  
2 8ZEB ? B ? ? UNP Q07817 ASN 54 deletion ? 83  
2 8ZEB ? B ? ? UNP Q07817 PRO 55 deletion ? 84  
2 8ZEB ? B ? ? UNP Q07817 SER 56 deletion ? 85  
2 8ZEB ? B ? ? UNP Q07817 TRP 57 deletion ? 86  
2 8ZEB ? B ? ? UNP Q07817 HIS 58 deletion ? 87  
2 8ZEB ? B ? ? UNP Q07817 LEU 59 deletion ? 88  
2 8ZEB ? B ? ? UNP Q07817 ALA 60 deletion ? 89  
2 8ZEB ? B ? ? UNP Q07817 ASP 61 deletion ? 90  
2 8ZEB ? B ? ? UNP Q07817 SER 62 deletion ? 91  
2 8ZEB ? B ? ? UNP Q07817 PRO 63 deletion ? 92  
2 8ZEB ? B ? ? UNP Q07817 ALA 64 deletion ? 93  
2 8ZEB ? B ? ? UNP Q07817 VAL 65 deletion ? 94  
2 8ZEB ? B ? ? UNP Q07817 ASN 66 deletion ? 95  
2 8ZEB ? B ? ? UNP Q07817 GLY 67 deletion ? 96  
2 8ZEB ? B ? ? UNP Q07817 ALA 68 deletion ? 97  
2 8ZEB ? B ? ? UNP Q07817 THR 69 deletion ? 98  
2 8ZEB ? B ? ? UNP Q07817 GLY 70 deletion ? 99  
2 8ZEB ? B ? ? UNP Q07817 HIS 71 deletion ? 100 
2 8ZEB ? B ? ? UNP Q07817 SER 72 deletion ? 101 
2 8ZEB ? B ? ? UNP Q07817 SER 73 deletion ? 102 
2 8ZEB ? B ? ? UNP Q07817 SER 74 deletion ? 103 
2 8ZEB ? B ? ? UNP Q07817 LEU 75 deletion ? 104 
2 8ZEB ? B ? ? UNP Q07817 ASP 76 deletion ? 105 
2 8ZEB ? B ? ? UNP Q07817 ALA 77 deletion ? 106 
2 8ZEB ? B ? ? UNP Q07817 ARG 78 deletion ? 107 
2 8ZEB ? B ? ? UNP Q07817 GLU 79 deletion ? 108 
2 8ZEB ? B ? ? UNP Q07817 VAL 80 deletion ? 109 
2 8ZEB ? B ? ? UNP Q07817 ILE 81 deletion ? 110 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA tetrameric 4 
2 author_and_software_defined_assembly PISA dimeric    2 
3 author_and_software_defined_assembly PISA dimeric    2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 6720  ? 
1 MORE         -50   ? 
1 'SSA (A^2)'  14560 ? 
2 'ABSA (A^2)' 1210  ? 
2 MORE         -9    ? 
2 'SSA (A^2)'  9500  ? 
3 'ABSA (A^2)' 1150  ? 
3 MORE         -8    ? 
3 'SSA (A^2)'  9420  ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,C,D,E,F,G,H 
2 1 A,D,E,H         
3 1 B,C,F,G         
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'surface plasmon resonance' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 4   ? LYS A 20  ? SER A 4   LYS A 20  1 ? 17 
HELX_P HELX_P2  AA2 GLN A 26  ? TYR A 46  ? GLN A 26  TYR A 101 1 ? 21 
HELX_P HELX_P3  AA3 TYR A 46  ? SER A 55  ? TYR A 101 SER A 110 1 ? 10 
HELX_P HELX_P4  AA4 ALA A 64  ? PHE A 76  ? ALA A 119 PHE A 131 1 ? 13 
HELX_P HELX_P5  AA5 ASN A 81  ? LYS A 102 ? ASN A 136 LYS A 157 1 ? 22 
HELX_P HELX_P6  AA6 VAL A 106 ? LEU A 123 ? VAL A 161 LEU A 178 1 ? 18 
HELX_P HELX_P7  AA7 LEU A 123 ? ASN A 130 ? LEU A 178 ASN A 185 1 ? 8  
HELX_P HELX_P8  AA8 GLY A 132 ? GLY A 141 ? GLY A 187 GLY A 196 1 ? 10 
HELX_P HELX_P9  AA9 SER B 4   ? LYS B 20  ? SER B 4   LYS B 20  1 ? 17 
HELX_P HELX_P10 AB1 MET B 28  ? TYR B 46  ? MET B 83  TYR B 101 1 ? 19 
HELX_P HELX_P11 AB2 TYR B 46  ? SER B 55  ? TYR B 101 SER B 110 1 ? 10 
HELX_P HELX_P12 AB3 ALA B 64  ? PHE B 76  ? ALA B 119 PHE B 131 1 ? 13 
HELX_P HELX_P13 AB4 ASN B 81  ? LYS B 102 ? ASN B 136 LYS B 157 1 ? 22 
HELX_P HELX_P14 AB5 VAL B 106 ? LEU B 123 ? VAL B 161 LEU B 178 1 ? 18 
HELX_P HELX_P15 AB6 LEU B 123 ? ASN B 130 ? LEU B 178 ASN B 185 1 ? 8  
HELX_P HELX_P16 AB7 GLY B 131 ? GLY B 141 ? GLY B 186 GLY B 196 1 ? 11 
HELX_P HELX_P17 AB8 PRO C 2   ? SER C 6   ? PRO D 2   SER D 6   1 ? 5  
HELX_P HELX_P18 AB9 PRO D 2   ? SER D 6   ? PRO C 2   SER C 6   1 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale both ? C THR 1  N   ? ? ? 1_555 C PRS 15 C   ? ? D THR 1  D PRS 15 1_555 ? ? ? ? ? ? ? 1.341 ? ? 
covale2  covale both ? C GLU 11 C   ? ? ? 1_555 C CCS 12 N   ? ? D GLU 11 D CCS 12 1_555 ? ? ? ? ? ? ? 1.333 ? ? 
covale3  covale one  ? C CCS 12 CE  ? ? ? 1_555 C EDN 13 NAA ? ? D CCS 12 D EDN 13 1_555 ? ? ? ? ? ? ? 1.327 ? ? 
covale4  covale both ? C EDN 13 NAD ? ? ? 1_555 C Z7Z 14 C1  ? ? D EDN 13 D Z7Z 14 1_555 ? ? ? ? ? ? ? 1.334 ? ? 
covale5  covale one  ? C Z7Z 14 C13 ? ? ? 1_555 C PRS 15 CD  ? ? D Z7Z 14 D PRS 15 1_555 ? ? ? ? ? ? ? 1.471 ? ? 
covale6  covale both ? D THR 1  N   ? ? ? 1_555 D PRS 15 C   ? ? C THR 1  C PRS 15 1_555 ? ? ? ? ? ? ? 1.336 ? ? 
covale7  covale both ? D GLU 11 C   ? ? ? 1_555 D CCS 12 N   ? ? C GLU 11 C CCS 12 1_555 ? ? ? ? ? ? ? 1.334 ? ? 
covale8  covale one  ? D CCS 12 CE  ? ? ? 1_555 D EDN 13 NAA ? ? C CCS 12 C EDN 13 1_555 ? ? ? ? ? ? ? 1.332 ? ? 
covale9  covale both ? D EDN 13 NAD ? ? ? 1_555 D Z7Z 14 C1  ? ? C EDN 13 C Z7Z 14 1_555 ? ? ? ? ? ? ? 1.335 ? ? 
covale10 covale one  ? D Z7Z 14 C13 ? ? ? 1_555 D PRS 15 CD  ? ? C Z7Z 14 C PRS 15 1_555 ? ? ? ? ? ? ? 1.475 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  CCS C 12 ? .   . .  . CCS D 12 ? 1_555 .   . .  . .     .   .   CYS 1 CCS Carboxymethylation 'Named protein modification' 
2  CCS D 12 ? .   . .  . CCS C 12 ? 1_555 .   . .  . .     .   .   CYS 1 CCS Carboxymethylation 'Named protein modification' 
3  EDN C 13 ? .   . .  . EDN D 13 ? 1_555 .   . .  . .     .   .   ?   1 EDN None               'Non-standard residue'       
4  Z7Z C 14 ? .   . .  . Z7Z D 14 ? 1_555 .   . .  . .     .   .   ?   1 Z7Z None               'Non-standard residue'       
5  PRS C 15 ? .   . .  . PRS D 15 ? 1_555 .   . .  . .     .   .   PRO 1 PRS None               'Non-standard residue'       
6  EDN D 13 ? .   . .  . EDN C 13 ? 1_555 .   . .  . .     .   .   ?   1 EDN None               'Non-standard residue'       
7  Z7Z D 14 ? .   . .  . Z7Z C 14 ? 1_555 .   . .  . .     .   .   ?   1 Z7Z None               'Non-standard residue'       
8  PRS D 15 ? .   . .  . PRS C 15 ? 1_555 .   . .  . .     .   .   PRO 1 PRS None               'Non-standard residue'       
9  THR C 1  ? PRS C 15 ? THR D 1  ? 1_555 PRS D 15 ? 1_555 N   C   .   . .   None               'Non-standard linkage'       
10 CCS C 12 ? EDN C 13 ? CCS D 12 ? 1_555 EDN D 13 ? 1_555 CE  NAA .   . .   None               'Non-standard linkage'       
11 Z7Z C 14 ? PRS C 15 ? Z7Z D 14 ? 1_555 PRS D 15 ? 1_555 C13 CD  .   . .   None               'Non-standard linkage'       
12 THR D 1  ? PRS D 15 ? THR C 1  ? 1_555 PRS C 15 ? 1_555 N   C   .   . .   None               'Non-standard linkage'       
13 CCS D 12 ? EDN D 13 ? CCS C 12 ? 1_555 EDN C 13 ? 1_555 CE  NAA .   . .   None               'Non-standard linkage'       
14 Z7Z D 14 ? PRS D 15 ? Z7Z C 14 ? 1_555 PRS C 15 ? 1_555 C13 CD  .   . .   None               'Non-standard linkage'       
# 
_pdbx_entry_details.entry_id                   8ZEB 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    SER 
_pdbx_validate_torsion.auth_asym_id    B 
_pdbx_validate_torsion.auth_seq_id     25 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             66.87 
_pdbx_validate_torsion.psi             132.47 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A MET 1 ? A MET 1 
2 1 Y 1 A SER 2 ? A SER 2 
3 1 Y 1 B MET 1 ? B MET 1 
4 1 Y 1 B SER 2 ? B SER 2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CCS N    N N N 74  
CCS CA   C N R 75  
CCS CB   C N N 76  
CCS SG   S N N 77  
CCS CD   C N N 78  
CCS CE   C N N 79  
CCS OZ1  O N N 80  
CCS OZ2  O N N 81  
CCS C    C N N 82  
CCS O    O N N 83  
CCS OXT  O N N 84  
CCS H    H N N 85  
CCS H2   H N N 86  
CCS HA   H N N 87  
CCS HB2  H N N 88  
CCS HB3  H N N 89  
CCS HD2  H N N 90  
CCS HD3  H N N 91  
CCS HZ2  H N N 92  
CCS HXT  H N N 93  
CYS N    N N N 94  
CYS CA   C N R 95  
CYS C    C N N 96  
CYS O    O N N 97  
CYS CB   C N N 98  
CYS SG   S N N 99  
CYS OXT  O N N 100 
CYS H    H N N 101 
CYS H2   H N N 102 
CYS HA   H N N 103 
CYS HB2  H N N 104 
CYS HB3  H N N 105 
CYS HG   H N N 106 
CYS HXT  H N N 107 
EDN NAA  N N N 108 
EDN CAB  C N N 109 
EDN CAC  C N N 110 
EDN NAD  N N N 111 
EDN HAA1 H N N 112 
EDN HAA2 H N N 113 
EDN HAB1 H N N 114 
EDN HAB2 H N N 115 
EDN HAC1 H N N 116 
EDN HAC2 H N N 117 
EDN HAD1 H N N 118 
EDN HAD2 H N N 119 
GLN N    N N N 120 
GLN CA   C N S 121 
GLN C    C N N 122 
GLN O    O N N 123 
GLN CB   C N N 124 
GLN CG   C N N 125 
GLN CD   C N N 126 
GLN OE1  O N N 127 
GLN NE2  N N N 128 
GLN OXT  O N N 129 
GLN H    H N N 130 
GLN H2   H N N 131 
GLN HA   H N N 132 
GLN HB2  H N N 133 
GLN HB3  H N N 134 
GLN HG2  H N N 135 
GLN HG3  H N N 136 
GLN HE21 H N N 137 
GLN HE22 H N N 138 
GLN HXT  H N N 139 
GLU N    N N N 140 
GLU CA   C N S 141 
GLU C    C N N 142 
GLU O    O N N 143 
GLU CB   C N N 144 
GLU CG   C N N 145 
GLU CD   C N N 146 
GLU OE1  O N N 147 
GLU OE2  O N N 148 
GLU OXT  O N N 149 
GLU H    H N N 150 
GLU H2   H N N 151 
GLU HA   H N N 152 
GLU HB2  H N N 153 
GLU HB3  H N N 154 
GLU HG2  H N N 155 
GLU HG3  H N N 156 
GLU HE2  H N N 157 
GLU HXT  H N N 158 
GLY N    N N N 159 
GLY CA   C N N 160 
GLY C    C N N 161 
GLY O    O N N 162 
GLY OXT  O N N 163 
GLY H    H N N 164 
GLY H2   H N N 165 
GLY HA2  H N N 166 
GLY HA3  H N N 167 
GLY HXT  H N N 168 
HIS N    N N N 169 
HIS CA   C N S 170 
HIS C    C N N 171 
HIS O    O N N 172 
HIS CB   C N N 173 
HIS CG   C Y N 174 
HIS ND1  N Y N 175 
HIS CD2  C Y N 176 
HIS CE1  C Y N 177 
HIS NE2  N Y N 178 
HIS OXT  O N N 179 
HIS H    H N N 180 
HIS H2   H N N 181 
HIS HA   H N N 182 
HIS HB2  H N N 183 
HIS HB3  H N N 184 
HIS HD1  H N N 185 
HIS HD2  H N N 186 
HIS HE1  H N N 187 
HIS HE2  H N N 188 
HIS HXT  H N N 189 
HOH O    O N N 190 
HOH H1   H N N 191 
HOH H2   H N N 192 
ILE N    N N N 193 
ILE CA   C N S 194 
ILE C    C N N 195 
ILE O    O N N 196 
ILE CB   C N S 197 
ILE CG1  C N N 198 
ILE CG2  C N N 199 
ILE CD1  C N N 200 
ILE OXT  O N N 201 
ILE H    H N N 202 
ILE H2   H N N 203 
ILE HA   H N N 204 
ILE HB   H N N 205 
ILE HG12 H N N 206 
ILE HG13 H N N 207 
ILE HG21 H N N 208 
ILE HG22 H N N 209 
ILE HG23 H N N 210 
ILE HD11 H N N 211 
ILE HD12 H N N 212 
ILE HD13 H N N 213 
ILE HXT  H N N 214 
LEU N    N N N 215 
LEU CA   C N S 216 
LEU C    C N N 217 
LEU O    O N N 218 
LEU CB   C N N 219 
LEU CG   C N N 220 
LEU CD1  C N N 221 
LEU CD2  C N N 222 
LEU OXT  O N N 223 
LEU H    H N N 224 
LEU H2   H N N 225 
LEU HA   H N N 226 
LEU HB2  H N N 227 
LEU HB3  H N N 228 
LEU HG   H N N 229 
LEU HD11 H N N 230 
LEU HD12 H N N 231 
LEU HD13 H N N 232 
LEU HD21 H N N 233 
LEU HD22 H N N 234 
LEU HD23 H N N 235 
LEU HXT  H N N 236 
LYS N    N N N 237 
LYS CA   C N S 238 
LYS C    C N N 239 
LYS O    O N N 240 
LYS CB   C N N 241 
LYS CG   C N N 242 
LYS CD   C N N 243 
LYS CE   C N N 244 
LYS NZ   N N N 245 
LYS OXT  O N N 246 
LYS H    H N N 247 
LYS H2   H N N 248 
LYS HA   H N N 249 
LYS HB2  H N N 250 
LYS HB3  H N N 251 
LYS HG2  H N N 252 
LYS HG3  H N N 253 
LYS HD2  H N N 254 
LYS HD3  H N N 255 
LYS HE2  H N N 256 
LYS HE3  H N N 257 
LYS HZ1  H N N 258 
LYS HZ2  H N N 259 
LYS HZ3  H N N 260 
LYS HXT  H N N 261 
MET N    N N N 262 
MET CA   C N S 263 
MET C    C N N 264 
MET O    O N N 265 
MET CB   C N N 266 
MET CG   C N N 267 
MET SD   S N N 268 
MET CE   C N N 269 
MET OXT  O N N 270 
MET H    H N N 271 
MET H2   H N N 272 
MET HA   H N N 273 
MET HB2  H N N 274 
MET HB3  H N N 275 
MET HG2  H N N 276 
MET HG3  H N N 277 
MET HE1  H N N 278 
MET HE2  H N N 279 
MET HE3  H N N 280 
MET HXT  H N N 281 
PHE N    N N N 282 
PHE CA   C N S 283 
PHE C    C N N 284 
PHE O    O N N 285 
PHE CB   C N N 286 
PHE CG   C Y N 287 
PHE CD1  C Y N 288 
PHE CD2  C Y N 289 
PHE CE1  C Y N 290 
PHE CE2  C Y N 291 
PHE CZ   C Y N 292 
PHE OXT  O N N 293 
PHE H    H N N 294 
PHE H2   H N N 295 
PHE HA   H N N 296 
PHE HB2  H N N 297 
PHE HB3  H N N 298 
PHE HD1  H N N 299 
PHE HD2  H N N 300 
PHE HE1  H N N 301 
PHE HE2  H N N 302 
PHE HZ   H N N 303 
PHE HXT  H N N 304 
PRO N    N N N 305 
PRO CA   C N S 306 
PRO C    C N N 307 
PRO O    O N N 308 
PRO CB   C N N 309 
PRO CG   C N N 310 
PRO CD   C N N 311 
PRO OXT  O N N 312 
PRO H    H N N 313 
PRO HA   H N N 314 
PRO HB2  H N N 315 
PRO HB3  H N N 316 
PRO HG2  H N N 317 
PRO HG3  H N N 318 
PRO HD2  H N N 319 
PRO HD3  H N N 320 
PRO HXT  H N N 321 
PRS N    N N N 322 
PRS CD   C N N 323 
PRS CA   C N R 324 
PRS CB   C N N 325 
PRS SG   S N N 326 
PRS C    C N N 327 
PRS O    O N N 328 
PRS OXT  O N N 329 
PRS H    H N N 330 
PRS HD3  H N N 331 
PRS HD2  H N N 332 
PRS HA   H N N 333 
PRS HB2  H N N 334 
PRS HB3  H N N 335 
PRS HXT  H N N 336 
SER N    N N N 337 
SER CA   C N S 338 
SER C    C N N 339 
SER O    O N N 340 
SER CB   C N N 341 
SER OG   O N N 342 
SER OXT  O N N 343 
SER H    H N N 344 
SER H2   H N N 345 
SER HA   H N N 346 
SER HB2  H N N 347 
SER HB3  H N N 348 
SER HG   H N N 349 
SER HXT  H N N 350 
THR N    N N N 351 
THR CA   C N S 352 
THR C    C N N 353 
THR O    O N N 354 
THR CB   C N R 355 
THR OG1  O N N 356 
THR CG2  C N N 357 
THR OXT  O N N 358 
THR H    H N N 359 
THR H2   H N N 360 
THR HA   H N N 361 
THR HB   H N N 362 
THR HG1  H N N 363 
THR HG21 H N N 364 
THR HG22 H N N 365 
THR HG23 H N N 366 
THR HXT  H N N 367 
TRP N    N N N 368 
TRP CA   C N S 369 
TRP C    C N N 370 
TRP O    O N N 371 
TRP CB   C N N 372 
TRP CG   C Y N 373 
TRP CD1  C Y N 374 
TRP CD2  C Y N 375 
TRP NE1  N Y N 376 
TRP CE2  C Y N 377 
TRP CE3  C Y N 378 
TRP CZ2  C Y N 379 
TRP CZ3  C Y N 380 
TRP CH2  C Y N 381 
TRP OXT  O N N 382 
TRP H    H N N 383 
TRP H2   H N N 384 
TRP HA   H N N 385 
TRP HB2  H N N 386 
TRP HB3  H N N 387 
TRP HD1  H N N 388 
TRP HE1  H N N 389 
TRP HE3  H N N 390 
TRP HZ2  H N N 391 
TRP HZ3  H N N 392 
TRP HH2  H N N 393 
TRP HXT  H N N 394 
TYR N    N N N 395 
TYR CA   C N S 396 
TYR C    C N N 397 
TYR O    O N N 398 
TYR CB   C N N 399 
TYR CG   C Y N 400 
TYR CD1  C Y N 401 
TYR CD2  C Y N 402 
TYR CE1  C Y N 403 
TYR CE2  C Y N 404 
TYR CZ   C Y N 405 
TYR OH   O N N 406 
TYR OXT  O N N 407 
TYR H    H N N 408 
TYR H2   H N N 409 
TYR HA   H N N 410 
TYR HB2  H N N 411 
TYR HB3  H N N 412 
TYR HD1  H N N 413 
TYR HD2  H N N 414 
TYR HE1  H N N 415 
TYR HE2  H N N 416 
TYR HH   H N N 417 
TYR HXT  H N N 418 
VAL N    N N N 419 
VAL CA   C N S 420 
VAL C    C N N 421 
VAL O    O N N 422 
VAL CB   C N N 423 
VAL CG1  C N N 424 
VAL CG2  C N N 425 
VAL OXT  O N N 426 
VAL H    H N N 427 
VAL H2   H N N 428 
VAL HA   H N N 429 
VAL HB   H N N 430 
VAL HG11 H N N 431 
VAL HG12 H N N 432 
VAL HG13 H N N 433 
VAL HG21 H N N 434 
VAL HG22 H N N 435 
VAL HG23 H N N 436 
VAL HXT  H N N 437 
Z7Z O1   O N N 438 
Z7Z C1   C N N 439 
Z7Z O2   O N N 440 
Z7Z C2   C Y N 441 
Z7Z C3   C Y N 442 
Z7Z C4   C Y N 443 
Z7Z C5   C Y N 444 
Z7Z C6   C Y N 445 
Z7Z C7   C Y N 446 
Z7Z C8   C Y N 447 
Z7Z C9   C Y N 448 
Z7Z C10  C Y N 449 
Z7Z C11  C Y N 450 
Z7Z C12  C Y N 451 
Z7Z C13  C Y N 452 
Z7Z H1O  H N N 453 
Z7Z H31  H N N 454 
Z7Z H41  H N N 455 
Z7Z H51  H N N 456 
Z7Z H61  H N N 457 
Z7Z H91  H N N 458 
Z7Z H101 H N N 459 
Z7Z H111 H N N 460 
Z7Z H121 H N N 461 
Z7Z H131 H N N 462 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CCS N   CA   sing N N 70  
CCS N   H    sing N N 71  
CCS N   H2   sing N N 72  
CCS CA  CB   sing N N 73  
CCS CA  C    sing N N 74  
CCS CA  HA   sing N N 75  
CCS CB  SG   sing N N 76  
CCS CB  HB2  sing N N 77  
CCS CB  HB3  sing N N 78  
CCS SG  CD   sing N N 79  
CCS CD  CE   sing N N 80  
CCS CD  HD2  sing N N 81  
CCS CD  HD3  sing N N 82  
CCS CE  OZ1  doub N N 83  
CCS CE  OZ2  sing N N 84  
CCS OZ2 HZ2  sing N N 85  
CCS C   O    doub N N 86  
CCS C   OXT  sing N N 87  
CCS OXT HXT  sing N N 88  
CYS N   CA   sing N N 89  
CYS N   H    sing N N 90  
CYS N   H2   sing N N 91  
CYS CA  C    sing N N 92  
CYS CA  CB   sing N N 93  
CYS CA  HA   sing N N 94  
CYS C   O    doub N N 95  
CYS C   OXT  sing N N 96  
CYS CB  SG   sing N N 97  
CYS CB  HB2  sing N N 98  
CYS CB  HB3  sing N N 99  
CYS SG  HG   sing N N 100 
CYS OXT HXT  sing N N 101 
EDN NAA CAB  sing N N 102 
EDN CAB CAC  sing N N 103 
EDN CAC NAD  sing N N 104 
EDN NAA HAA1 sing N N 105 
EDN NAA HAA2 sing N N 106 
EDN CAB HAB1 sing N N 107 
EDN CAB HAB2 sing N N 108 
EDN CAC HAC1 sing N N 109 
EDN CAC HAC2 sing N N 110 
EDN NAD HAD1 sing N N 111 
EDN NAD HAD2 sing N N 112 
GLN N   CA   sing N N 113 
GLN N   H    sing N N 114 
GLN N   H2   sing N N 115 
GLN CA  C    sing N N 116 
GLN CA  CB   sing N N 117 
GLN CA  HA   sing N N 118 
GLN C   O    doub N N 119 
GLN C   OXT  sing N N 120 
GLN CB  CG   sing N N 121 
GLN CB  HB2  sing N N 122 
GLN CB  HB3  sing N N 123 
GLN CG  CD   sing N N 124 
GLN CG  HG2  sing N N 125 
GLN CG  HG3  sing N N 126 
GLN CD  OE1  doub N N 127 
GLN CD  NE2  sing N N 128 
GLN NE2 HE21 sing N N 129 
GLN NE2 HE22 sing N N 130 
GLN OXT HXT  sing N N 131 
GLU N   CA   sing N N 132 
GLU N   H    sing N N 133 
GLU N   H2   sing N N 134 
GLU CA  C    sing N N 135 
GLU CA  CB   sing N N 136 
GLU CA  HA   sing N N 137 
GLU C   O    doub N N 138 
GLU C   OXT  sing N N 139 
GLU CB  CG   sing N N 140 
GLU CB  HB2  sing N N 141 
GLU CB  HB3  sing N N 142 
GLU CG  CD   sing N N 143 
GLU CG  HG2  sing N N 144 
GLU CG  HG3  sing N N 145 
GLU CD  OE1  doub N N 146 
GLU CD  OE2  sing N N 147 
GLU OE2 HE2  sing N N 148 
GLU OXT HXT  sing N N 149 
GLY N   CA   sing N N 150 
GLY N   H    sing N N 151 
GLY N   H2   sing N N 152 
GLY CA  C    sing N N 153 
GLY CA  HA2  sing N N 154 
GLY CA  HA3  sing N N 155 
GLY C   O    doub N N 156 
GLY C   OXT  sing N N 157 
GLY OXT HXT  sing N N 158 
HIS N   CA   sing N N 159 
HIS N   H    sing N N 160 
HIS N   H2   sing N N 161 
HIS CA  C    sing N N 162 
HIS CA  CB   sing N N 163 
HIS CA  HA   sing N N 164 
HIS C   O    doub N N 165 
HIS C   OXT  sing N N 166 
HIS CB  CG   sing N N 167 
HIS CB  HB2  sing N N 168 
HIS CB  HB3  sing N N 169 
HIS CG  ND1  sing Y N 170 
HIS CG  CD2  doub Y N 171 
HIS ND1 CE1  doub Y N 172 
HIS ND1 HD1  sing N N 173 
HIS CD2 NE2  sing Y N 174 
HIS CD2 HD2  sing N N 175 
HIS CE1 NE2  sing Y N 176 
HIS CE1 HE1  sing N N 177 
HIS NE2 HE2  sing N N 178 
HIS OXT HXT  sing N N 179 
HOH O   H1   sing N N 180 
HOH O   H2   sing N N 181 
ILE N   CA   sing N N 182 
ILE N   H    sing N N 183 
ILE N   H2   sing N N 184 
ILE CA  C    sing N N 185 
ILE CA  CB   sing N N 186 
ILE CA  HA   sing N N 187 
ILE C   O    doub N N 188 
ILE C   OXT  sing N N 189 
ILE CB  CG1  sing N N 190 
ILE CB  CG2  sing N N 191 
ILE CB  HB   sing N N 192 
ILE CG1 CD1  sing N N 193 
ILE CG1 HG12 sing N N 194 
ILE CG1 HG13 sing N N 195 
ILE CG2 HG21 sing N N 196 
ILE CG2 HG22 sing N N 197 
ILE CG2 HG23 sing N N 198 
ILE CD1 HD11 sing N N 199 
ILE CD1 HD12 sing N N 200 
ILE CD1 HD13 sing N N 201 
ILE OXT HXT  sing N N 202 
LEU N   CA   sing N N 203 
LEU N   H    sing N N 204 
LEU N   H2   sing N N 205 
LEU CA  C    sing N N 206 
LEU CA  CB   sing N N 207 
LEU CA  HA   sing N N 208 
LEU C   O    doub N N 209 
LEU C   OXT  sing N N 210 
LEU CB  CG   sing N N 211 
LEU CB  HB2  sing N N 212 
LEU CB  HB3  sing N N 213 
LEU CG  CD1  sing N N 214 
LEU CG  CD2  sing N N 215 
LEU CG  HG   sing N N 216 
LEU CD1 HD11 sing N N 217 
LEU CD1 HD12 sing N N 218 
LEU CD1 HD13 sing N N 219 
LEU CD2 HD21 sing N N 220 
LEU CD2 HD22 sing N N 221 
LEU CD2 HD23 sing N N 222 
LEU OXT HXT  sing N N 223 
LYS N   CA   sing N N 224 
LYS N   H    sing N N 225 
LYS N   H2   sing N N 226 
LYS CA  C    sing N N 227 
LYS CA  CB   sing N N 228 
LYS CA  HA   sing N N 229 
LYS C   O    doub N N 230 
LYS C   OXT  sing N N 231 
LYS CB  CG   sing N N 232 
LYS CB  HB2  sing N N 233 
LYS CB  HB3  sing N N 234 
LYS CG  CD   sing N N 235 
LYS CG  HG2  sing N N 236 
LYS CG  HG3  sing N N 237 
LYS CD  CE   sing N N 238 
LYS CD  HD2  sing N N 239 
LYS CD  HD3  sing N N 240 
LYS CE  NZ   sing N N 241 
LYS CE  HE2  sing N N 242 
LYS CE  HE3  sing N N 243 
LYS NZ  HZ1  sing N N 244 
LYS NZ  HZ2  sing N N 245 
LYS NZ  HZ3  sing N N 246 
LYS OXT HXT  sing N N 247 
MET N   CA   sing N N 248 
MET N   H    sing N N 249 
MET N   H2   sing N N 250 
MET CA  C    sing N N 251 
MET CA  CB   sing N N 252 
MET CA  HA   sing N N 253 
MET C   O    doub N N 254 
MET C   OXT  sing N N 255 
MET CB  CG   sing N N 256 
MET CB  HB2  sing N N 257 
MET CB  HB3  sing N N 258 
MET CG  SD   sing N N 259 
MET CG  HG2  sing N N 260 
MET CG  HG3  sing N N 261 
MET SD  CE   sing N N 262 
MET CE  HE1  sing N N 263 
MET CE  HE2  sing N N 264 
MET CE  HE3  sing N N 265 
MET OXT HXT  sing N N 266 
PHE N   CA   sing N N 267 
PHE N   H    sing N N 268 
PHE N   H2   sing N N 269 
PHE CA  C    sing N N 270 
PHE CA  CB   sing N N 271 
PHE CA  HA   sing N N 272 
PHE C   O    doub N N 273 
PHE C   OXT  sing N N 274 
PHE CB  CG   sing N N 275 
PHE CB  HB2  sing N N 276 
PHE CB  HB3  sing N N 277 
PHE CG  CD1  doub Y N 278 
PHE CG  CD2  sing Y N 279 
PHE CD1 CE1  sing Y N 280 
PHE CD1 HD1  sing N N 281 
PHE CD2 CE2  doub Y N 282 
PHE CD2 HD2  sing N N 283 
PHE CE1 CZ   doub Y N 284 
PHE CE1 HE1  sing N N 285 
PHE CE2 CZ   sing Y N 286 
PHE CE2 HE2  sing N N 287 
PHE CZ  HZ   sing N N 288 
PHE OXT HXT  sing N N 289 
PRO N   CA   sing N N 290 
PRO N   CD   sing N N 291 
PRO N   H    sing N N 292 
PRO CA  C    sing N N 293 
PRO CA  CB   sing N N 294 
PRO CA  HA   sing N N 295 
PRO C   O    doub N N 296 
PRO C   OXT  sing N N 297 
PRO CB  CG   sing N N 298 
PRO CB  HB2  sing N N 299 
PRO CB  HB3  sing N N 300 
PRO CG  CD   sing N N 301 
PRO CG  HG2  sing N N 302 
PRO CG  HG3  sing N N 303 
PRO CD  HD2  sing N N 304 
PRO CD  HD3  sing N N 305 
PRO OXT HXT  sing N N 306 
PRS N   CD   sing N N 307 
PRS N   CA   sing N N 308 
PRS N   H    sing N N 309 
PRS CD  SG   sing N N 310 
PRS CD  HD3  sing N N 311 
PRS CD  HD2  sing N N 312 
PRS CA  CB   sing N N 313 
PRS CA  C    sing N N 314 
PRS CA  HA   sing N N 315 
PRS CB  SG   sing N N 316 
PRS CB  HB2  sing N N 317 
PRS CB  HB3  sing N N 318 
PRS C   O    doub N N 319 
PRS C   OXT  sing N N 320 
PRS OXT HXT  sing N N 321 
SER N   CA   sing N N 322 
SER N   H    sing N N 323 
SER N   H2   sing N N 324 
SER CA  C    sing N N 325 
SER CA  CB   sing N N 326 
SER CA  HA   sing N N 327 
SER C   O    doub N N 328 
SER C   OXT  sing N N 329 
SER CB  OG   sing N N 330 
SER CB  HB2  sing N N 331 
SER CB  HB3  sing N N 332 
SER OG  HG   sing N N 333 
SER OXT HXT  sing N N 334 
THR N   CA   sing N N 335 
THR N   H    sing N N 336 
THR N   H2   sing N N 337 
THR CA  C    sing N N 338 
THR CA  CB   sing N N 339 
THR CA  HA   sing N N 340 
THR C   O    doub N N 341 
THR C   OXT  sing N N 342 
THR CB  OG1  sing N N 343 
THR CB  CG2  sing N N 344 
THR CB  HB   sing N N 345 
THR OG1 HG1  sing N N 346 
THR CG2 HG21 sing N N 347 
THR CG2 HG22 sing N N 348 
THR CG2 HG23 sing N N 349 
THR OXT HXT  sing N N 350 
TRP N   CA   sing N N 351 
TRP N   H    sing N N 352 
TRP N   H2   sing N N 353 
TRP CA  C    sing N N 354 
TRP CA  CB   sing N N 355 
TRP CA  HA   sing N N 356 
TRP C   O    doub N N 357 
TRP C   OXT  sing N N 358 
TRP CB  CG   sing N N 359 
TRP CB  HB2  sing N N 360 
TRP CB  HB3  sing N N 361 
TRP CG  CD1  doub Y N 362 
TRP CG  CD2  sing Y N 363 
TRP CD1 NE1  sing Y N 364 
TRP CD1 HD1  sing N N 365 
TRP CD2 CE2  doub Y N 366 
TRP CD2 CE3  sing Y N 367 
TRP NE1 CE2  sing Y N 368 
TRP NE1 HE1  sing N N 369 
TRP CE2 CZ2  sing Y N 370 
TRP CE3 CZ3  doub Y N 371 
TRP CE3 HE3  sing N N 372 
TRP CZ2 CH2  doub Y N 373 
TRP CZ2 HZ2  sing N N 374 
TRP CZ3 CH2  sing Y N 375 
TRP CZ3 HZ3  sing N N 376 
TRP CH2 HH2  sing N N 377 
TRP OXT HXT  sing N N 378 
TYR N   CA   sing N N 379 
TYR N   H    sing N N 380 
TYR N   H2   sing N N 381 
TYR CA  C    sing N N 382 
TYR CA  CB   sing N N 383 
TYR CA  HA   sing N N 384 
TYR C   O    doub N N 385 
TYR C   OXT  sing N N 386 
TYR CB  CG   sing N N 387 
TYR CB  HB2  sing N N 388 
TYR CB  HB3  sing N N 389 
TYR CG  CD1  doub Y N 390 
TYR CG  CD2  sing Y N 391 
TYR CD1 CE1  sing Y N 392 
TYR CD1 HD1  sing N N 393 
TYR CD2 CE2  doub Y N 394 
TYR CD2 HD2  sing N N 395 
TYR CE1 CZ   doub Y N 396 
TYR CE1 HE1  sing N N 397 
TYR CE2 CZ   sing Y N 398 
TYR CE2 HE2  sing N N 399 
TYR CZ  OH   sing N N 400 
TYR OH  HH   sing N N 401 
TYR OXT HXT  sing N N 402 
VAL N   CA   sing N N 403 
VAL N   H    sing N N 404 
VAL N   H2   sing N N 405 
VAL CA  C    sing N N 406 
VAL CA  CB   sing N N 407 
VAL CA  HA   sing N N 408 
VAL C   O    doub N N 409 
VAL C   OXT  sing N N 410 
VAL CB  CG1  sing N N 411 
VAL CB  CG2  sing N N 412 
VAL CB  HB   sing N N 413 
VAL CG1 HG11 sing N N 414 
VAL CG1 HG12 sing N N 415 
VAL CG1 HG13 sing N N 416 
VAL CG2 HG21 sing N N 417 
VAL CG2 HG22 sing N N 418 
VAL CG2 HG23 sing N N 419 
VAL OXT HXT  sing N N 420 
Z7Z O1  C1   sing N N 421 
Z7Z O1  H1O  sing N N 422 
Z7Z C1  O2   doub N N 423 
Z7Z C1  C2   sing N N 424 
Z7Z C2  C3   doub Y N 425 
Z7Z C2  C5   sing Y N 426 
Z7Z C3  C4   sing Y N 427 
Z7Z C3  H31  sing N N 428 
Z7Z C4  C7   doub Y N 429 
Z7Z C4  H41  sing N N 430 
Z7Z C5  C6   doub Y N 431 
Z7Z C5  H51  sing N N 432 
Z7Z C6  C7   sing Y N 433 
Z7Z C6  H61  sing N N 434 
Z7Z C7  C8   sing N N 435 
Z7Z C8  C9   doub Y N 436 
Z7Z C8  C10  sing Y N 437 
Z7Z C9  C11  sing Y N 438 
Z7Z C9  H91  sing N N 439 
Z7Z C10 C12  doub Y N 440 
Z7Z C10 H101 sing N N 441 
Z7Z C11 C13  doub Y N 442 
Z7Z C11 H111 sing N N 443 
Z7Z C12 C13  sing Y N 444 
Z7Z C12 H121 sing N N 445 
Z7Z C13 H131 sing N N 446 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           31800664 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7YAA 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8ZEB 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.015620 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010245 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010735 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 3   ? -7.00130  -3.71675  -40.64712 1.000 53.69666 ?  3   GLN A N   1 
ATOM   2    C CA  . GLN A 1 3   ? -6.96981  -5.06744  -41.20390 1.000 50.58042 ?  3   GLN A CA  1 
ATOM   3    C C   . GLN A 1 3   ? -5.62957  -5.73614  -40.93796 1.000 49.95710 ?  3   GLN A C   1 
ATOM   4    O O   . GLN A 1 3   ? -4.60652  -5.38738  -41.53835 1.000 53.56182 ?  3   GLN A O   1 
ATOM   5    C CB  . GLN A 1 3   ? -7.25994  -5.04085  -42.70552 1.000 53.84923 ?  3   GLN A CB  1 
ATOM   6    C CG  . GLN A 1 3   ? -8.74783  -5.17507  -43.04174 1.000 52.18769 ?  3   GLN A CG  1 
ATOM   7    C CD  . GLN A 1 3   ? -9.02622  -5.05930  -44.52857 1.000 51.95396 ?  3   GLN A CD  1 
ATOM   8    O OE1 . GLN A 1 3   ? -8.12863  -4.73581  -45.32055 1.000 50.01878 ?  3   GLN A OE1 1 
ATOM   9    N NE2 . GLN A 1 3   ? -10.27390 -5.32043  -44.91969 1.000 44.31616 ?  3   GLN A NE2 1 
ATOM   10   N N   . SER A 1 4   ? -5.64107  -6.70704  -40.03503 1.000 42.73847 ?  4   SER A N   1 
ATOM   11   C CA  . SER A 1 4   ? -4.41206  -7.31009  -39.54388 1.000 40.66754 ?  4   SER A CA  1 
ATOM   12   C C   . SER A 1 4   ? -4.07452  -8.56502  -40.35263 1.000 31.33290 ?  4   SER A C   1 
ATOM   13   O O   . SER A 1 4   ? -4.92650  -9.44209  -40.55933 1.000 33.26483 ?  4   SER A O   1 
ATOM   14   C CB  . SER A 1 4   ? -4.55786  -7.60520  -38.04814 1.000 36.72505 ?  4   SER A CB  1 
ATOM   15   O OG  . SER A 1 4   ? -3.80759  -8.71808  -37.63156 1.000 38.18734 ?  4   SER A OG  1 
ATOM   16   N N   . ASN A 1 5   ? -2.84370  -8.61291  -40.86228 1.000 33.32531 ?  5   ASN A N   1 
ATOM   17   C CA  . ASN A 1 5   ? -2.36978  -9.82634  -41.52183 1.000 35.56265 ?  5   ASN A CA  1 
ATOM   18   C C   . ASN A 1 5   ? -2.30007  -10.97816 -40.53553 1.000 28.96222 ?  5   ASN A C   1 
ATOM   19   O O   . ASN A 1 5   ? -2.53402  -12.13691 -40.90225 1.000 26.86672 ?  5   ASN A O   1 
ATOM   20   C CB  . ASN A 1 5   ? -0.99979  -9.57972  -42.16483 1.000 29.73332 ?  5   ASN A CB  1 
ATOM   21   C CG  . ASN A 1 5   ? -1.09669  -8.82323  -43.47396 1.000 30.19631 ?  5   ASN A CG  1 
ATOM   22   O OD1 . ASN A 1 5   ? -2.11227  -8.90640  -44.17532 1.000 34.08293 ?  5   ASN A OD1 1 
ATOM   23   N ND2 . ASN A 1 5   ? -0.03875  -8.09482  -43.82425 1.000 33.53190 ?  5   ASN A ND2 1 
ATOM   24   N N   . ARG A 1 6   ? -2.01128  -10.67416 -39.27400 1.000 29.14095 ?  6   ARG A N   1 
ATOM   25   C CA  . ARG A 1 6   ? -1.87738  -11.72274 -38.27280 1.000 32.20613 ?  6   ARG A CA  1 
ATOM   26   C C   . ARG A 1 6   ? -3.23291  -12.32747 -37.92715 1.000 28.44771 ?  6   ARG A C   1 
ATOM   27   O O   . ARG A 1 6   ? -3.34768  -13.54584 -37.74868 1.000 28.57090 ?  6   ARG A O   1 
ATOM   28   C CB  . ARG A 1 6   ? -1.17467  -11.14688 -37.03917 1.000 32.94097 ?  6   ARG A CB  1 
ATOM   29   C CG  . ARG A 1 6   ? -1.43987  -11.86414 -35.74056 1.000 35.24689 ?  6   ARG A CG  1 
ATOM   30   C CD  . ARG A 1 6   ? -0.91198  -11.03751 -34.58192 1.000 36.76915 ?  6   ARG A CD  1 
ATOM   31   N NE  . ARG A 1 6   ? -1.86070  -10.96829 -33.47522 1.000 42.29907 ?  6   ARG A NE  1 
ATOM   32   C CZ  . ARG A 1 6   ? -2.83647  -10.06766 -33.35994 1.000 44.26201 ?  6   ARG A CZ  1 
ATOM   33   N NH1 . ARG A 1 6   ? -3.02993  -9.12687  -34.28374 1.000 43.23609 ?  6   ARG A NH1 1 
ATOM   34   N NH2 . ARG A 1 6   ? -3.62312  -10.10943 -32.30055 1.000 52.78882 ?  6   ARG A NH2 1 
ATOM   35   N N   . GLU A 1 7   ? -4.28021  -11.49456 -37.84067 1.000 30.29657 ?  7   GLU A N   1 
ATOM   36   C CA  . GLU A 1 7   ? -5.63378  -12.01644 -37.64573 1.000 32.33717 ?  7   GLU A CA  1 
ATOM   37   C C   . GLU A 1 7   ? -6.03369  -12.93899 -38.78720 1.000 27.13416 ?  7   GLU A C   1 
ATOM   38   O O   . GLU A 1 7   ? -6.66373  -13.98526 -38.57062 1.000 26.41048 ?  7   GLU A O   1 
ATOM   39   C CB  . GLU A 1 7   ? -6.63846  -10.86733 -37.54562 1.000 33.11576 ?  7   GLU A CB  1 
ATOM   40   C CG  . GLU A 1 7   ? -6.86309  -10.30780 -36.16329 1.000 40.53965 ?  7   GLU A CG  1 
ATOM   41   C CD  . GLU A 1 7   ? -8.08360  -9.38691  -36.12819 1.000 49.09167 ?  7   GLU A CD  1 
ATOM   42   O OE1 . GLU A 1 7   ? -7.91628  -8.15646  -35.94408 1.000 53.19176 ?  7   GLU A OE1 1 
ATOM   43   O OE2 . GLU A 1 7   ? -9.21229  -9.89729  -36.32686 1.000 51.47996 -1 7   GLU A OE2 1 
ATOM   44   N N   . LEU A 1 8   ? -5.67196  -12.56556 -40.01510 1.000 24.63978 ?  8   LEU A N   1 
ATOM   45   C CA  . LEU A 1 8   ? -5.99522  -13.39017 -41.17242 1.000 22.28221 ?  8   LEU A CA  1 
ATOM   46   C C   . LEU A 1 8   ? -5.24577  -14.70811 -41.12257 1.000 25.75858 ?  8   LEU A C   1 
ATOM   47   O O   . LEU A 1 8   ? -5.81795  -15.76102 -41.42949 1.000 21.09296 ?  8   LEU A O   1 
ATOM   48   C CB  . LEU A 1 8   ? -5.62243  -12.65039 -42.44426 1.000 25.71729 ?  8   LEU A CB  1 
ATOM   49   C CG  . LEU A 1 8   ? -6.50170  -12.68297 -43.67365 1.000 32.68617 ?  8   LEU A CG  1 
ATOM   50   C CD1 . LEU A 1 8   ? -7.98536  -12.68839 -43.29767 1.000 31.38837 ?  8   LEU A CD1 1 
ATOM   51   C CD2 . LEU A 1 8   ? -6.11796  -11.45639 -44.48187 1.000 33.19958 ?  8   LEU A CD2 1 
ATOM   52   N N   . VAL A 1 9   ? -3.94981  -14.65422 -40.77684 1.000 19.97324 ?  9   VAL A N   1 
ATOM   53   C CA  . VAL A 1 9   ? -3.14548  -15.87340 -40.66948 1.000 21.22175 ?  9   VAL A CA  1 
ATOM   54   C C   . VAL A 1 9   ? -3.73206  -16.79311 -39.61181 1.000 21.41641 ?  9   VAL A C   1 
ATOM   55   O O   . VAL A 1 9   ? -3.90516  -17.99917 -39.83475 1.000 21.37520 ?  9   VAL A O   1 
ATOM   56   C CB  . VAL A 1 9   ? -1.67344  -15.53547 -40.36300 1.000 21.32966 ?  9   VAL A CB  1 
ATOM   57   C CG1 . VAL A 1 9   ? -0.89642  -16.81509 -39.88803 1.000 16.26105 ?  9   VAL A CG1 1 
ATOM   58   C CG2 . VAL A 1 9   ? -1.00928  -14.95219 -41.58796 1.000 18.88950 ?  9   VAL A CG2 1 
ATOM   59   N N   . VAL A 1 10  ? -4.07148  -16.23266 -38.44453 1.000 20.95294 ?  10  VAL A N   1 
ATOM   60   C CA  . VAL A 1 10  ? -4.49932  -17.11135 -37.36389 1.000 25.79370 ?  10  VAL A CA  1 
ATOM   61   C C   . VAL A 1 10  ? -5.84082  -17.73850 -37.68704 1.000 27.00145 ?  10  VAL A C   1 
ATOM   62   O O   . VAL A 1 10  ? -6.07350  -18.91211 -37.36276 1.000 24.82008 ?  10  VAL A O   1 
ATOM   63   C CB  . VAL A 1 10  ? -4.50571  -16.36371 -36.02140 1.000 28.21204 ?  10  VAL A CB  1 
ATOM   64   C CG1 . VAL A 1 10  ? -5.22342  -17.17522 -34.96762 1.000 31.17713 ?  10  VAL A CG1 1 
ATOM   65   C CG2 . VAL A 1 10  ? -3.06111  -16.08313 -35.57591 1.000 27.45351 ?  10  VAL A CG2 1 
ATOM   66   N N   . ASP A 1 11  ? -6.72500  -17.00068 -38.37561 1.000 27.18385 ?  11  ASP A N   1 
ATOM   67   C CA  . ASP A 1 11  ? -8.01673  -17.56899 -38.75808 1.000 28.12388 ?  11  ASP A CA  1 
ATOM   68   C C   . ASP A 1 11  ? -7.86008  -18.68307 -39.78759 1.000 27.20658 ?  11  ASP A C   1 
ATOM   69   O O   . ASP A 1 11  ? -8.54584  -19.71209 -39.70950 1.000 26.56770 ?  11  ASP A O   1 
ATOM   70   C CB  . ASP A 1 11  ? -8.94343  -16.48975 -39.32295 1.000 28.45287 ?  11  ASP A CB  1 
ATOM   71   C CG  . ASP A 1 11  ? -10.24841 -17.07250 -39.82175 1.000 32.23648 ?  11  ASP A CG  1 
ATOM   72   O OD1 . ASP A 1 11  ? -11.16788 -17.26643 -38.99166 1.000 33.54318 ?  11  ASP A OD1 1 
ATOM   73   O OD2 . ASP A 1 11  ? -10.34811 -17.35813 -41.03751 1.000 29.88480 -1 11  ASP A OD2 1 
ATOM   74   N N   . PHE A 1 12  ? -6.99954  -18.47963 -40.78774 1.000 24.15563 ?  12  PHE A N   1 
ATOM   75   C CA  . PHE A 1 12  ? -6.83674  -19.48687 -41.83229 1.000 23.48669 ?  12  PHE A CA  1 
ATOM   76   C C   . PHE A 1 12  ? -6.22622  -20.77216 -41.27266 1.000 23.08392 ?  12  PHE A C   1 
ATOM   77   O O   . PHE A 1 12  ? -6.69874  -21.87633 -41.56193 1.000 23.26696 ?  12  PHE A O   1 
ATOM   78   C CB  . PHE A 1 12  ? -5.96995  -18.93066 -42.96319 1.000 21.16508 ?  12  PHE A CB  1 
ATOM   79   C CG  . PHE A 1 12  ? -5.96165  -19.78824 -44.18204 1.000 21.25079 ?  12  PHE A CG  1 
ATOM   80   C CD1 . PHE A 1 12  ? -5.05332  -20.83554 -44.30776 1.000 22.49851 ?  12  PHE A CD1 1 
ATOM   81   C CD2 . PHE A 1 12  ? -6.86802  -19.56587 -45.19798 1.000 21.52777 ?  12  PHE A CD2 1 
ATOM   82   C CE1 . PHE A 1 12  ? -5.04251  -21.64305 -45.43699 1.000 21.03406 ?  12  PHE A CE1 1 
ATOM   83   C CE2 . PHE A 1 12  ? -6.87342  -20.36871 -46.33213 1.000 26.23877 ?  12  PHE A CE2 1 
ATOM   84   C CZ  . PHE A 1 12  ? -5.93249  -21.40989 -46.44852 1.000 25.48344 ?  12  PHE A CZ  1 
ATOM   85   N N   . LEU A 1 13  ? -5.15398  -20.64530 -40.49487 1.000 22.39872 ?  13  LEU A N   1 
ATOM   86   C CA  . LEU A 1 13  ? -4.54030  -21.82227 -39.88681 1.000 23.33200 ?  13  LEU A CA  1 
ATOM   87   C C   . LEU A 1 13  ? -5.52125  -22.55478 -38.96894 1.000 25.40378 ?  13  LEU A C   1 
ATOM   88   O O   . LEU A 1 13  ? -5.63210  -23.78528 -39.02766 1.000 24.23939 ?  13  LEU A O   1 
ATOM   89   C CB  . LEU A 1 13  ? -3.30003  -21.41152 -39.11157 1.000 19.15230 ?  13  LEU A CB  1 
ATOM   90   C CG  . LEU A 1 13  ? -2.20231  -20.75659 -39.95265 1.000 22.99301 ?  13  LEU A CG  1 
ATOM   91   C CD1 . LEU A 1 13  ? -1.05746  -20.42175 -39.04419 1.000 22.27918 ?  13  LEU A CD1 1 
ATOM   92   C CD2 . LEU A 1 13  ? -1.77636  -21.67806 -41.08905 1.000 20.73368 ?  13  LEU A CD2 1 
ATOM   93   N N   . SER A 1 14  ? -6.21621  -21.81623 -38.08910 1.000 24.34180 ?  14  SER A N   1 
ATOM   94   C CA  . SER A 1 14  ? -7.20736  -22.44447 -37.20253 1.000 30.15314 ?  14  SER A CA  1 
ATOM   95   C C   . SER A 1 14  ? -8.26076  -23.21790 -37.98979 1.000 28.63728 ?  14  SER A C   1 
ATOM   96   O O   . SER A 1 14  ? -8.64625  -24.33825 -37.61274 1.000 28.07484 ?  14  SER A O   1 
ATOM   97   C CB  . SER A 1 14  ? -7.90741  -21.39289 -36.33516 1.000 32.05322 ?  14  SER A CB  1 
ATOM   98   O OG  . SER A 1 14  ? -6.98035  -20.64615 -35.57217 1.000 41.44063 ?  14  SER A OG  1 
ATOM   99   N N   . TYR A 1 15  ? -8.74945  -22.62320 -39.07461 1.000 26.86678 ?  15  TYR A N   1 
ATOM   100  C CA  . TYR A 1 15  ? -9.70350  -23.29752 -39.94629 1.000 25.35747 ?  15  TYR A CA  1 
ATOM   101  C C   . TYR A 1 15  ? -9.09656  -24.54738 -40.56320 1.000 27.60412 ?  15  TYR A C   1 
ATOM   102  O O   . TYR A 1 15  ? -9.70995  -25.61909 -40.54957 1.000 28.35836 ?  15  TYR A O   1 
ATOM   103  C CB  . TYR A 1 15  ? -10.16867 -22.31751 -41.02815 1.000 31.41576 ?  15  TYR A CB  1 
ATOM   104  C CG  . TYR A 1 15  ? -11.07847 -22.90643 -42.08499 1.000 31.52599 ?  15  TYR A CG  1 
ATOM   105  C CD1 . TYR A 1 15  ? -12.37352 -23.31586 -41.76892 1.000 33.67910 ?  15  TYR A CD1 1 
ATOM   106  C CD2 . TYR A 1 15  ? -10.65625 -23.02546 -43.39983 1.000 31.28239 ?  15  TYR A CD2 1 
ATOM   107  C CE1 . TYR A 1 15  ? -13.22186 -23.83821 -42.73552 1.000 32.03151 ?  15  TYR A CE1 1 
ATOM   108  C CE2 . TYR A 1 15  ? -11.49582 -23.55295 -44.37025 1.000 28.22107 ?  15  TYR A CE2 1 
ATOM   109  C CZ  . TYR A 1 15  ? -12.77353 -23.95889 -44.02608 1.000 31.82356 ?  15  TYR A CZ  1 
ATOM   110  O OH  . TYR A 1 15  ? -13.60216 -24.47609 -44.99378 1.000 29.53259 ?  15  TYR A OH  1 
ATOM   111  N N   . LYS A 1 16  ? -7.89584  -24.42683 -41.13560 1.000 26.63666 ?  16  LYS A N   1 
ATOM   112  C CA  . LYS A 1 16  ? -7.28282  -25.57247 -41.79890 1.000 26.59148 ?  16  LYS A CA  1 
ATOM   113  C C   . LYS A 1 16  ? -6.99627  -26.70377 -40.82357 1.000 26.22365 ?  16  LYS A C   1 
ATOM   114  O O   . LYS A 1 16  ? -7.09200  -27.88104 -41.19531 1.000 31.79468 ?  16  LYS A O   1 
ATOM   115  C CB  . LYS A 1 16  ? -5.98801  -25.15232 -42.50759 1.000 24.42555 ?  16  LYS A CB  1 
ATOM   116  C CG  . LYS A 1 16  ? -6.21218  -24.83485 -43.98195 1.000 32.14881 ?  16  LYS A CG  1 
ATOM   117  C CD  . LYS A 1 16  ? -7.43372  -23.93639 -44.13010 1.000 32.74659 ?  16  LYS A CD  1 
ATOM   118  C CE  . LYS A 1 16  ? -7.81812  -23.67300 -45.58551 1.000 38.65679 ?  16  LYS A CE  1 
ATOM   119  N NZ  . LYS A 1 16  ? -8.29841  -24.86878 -46.31468 1.000 31.57731 ?  16  LYS A NZ  1 
ATOM   120  N N   . LEU A 1 17  ? -6.65245  -26.37052 -39.58081 1.000 22.36275 ?  17  LEU A N   1 
ATOM   121  C CA  . LEU A 1 17  ? -6.40376  -27.39887 -38.57681 1.000 27.81699 ?  17  LEU A CA  1 
ATOM   122  C C   . LEU A 1 17  ? -7.69851  -28.08829 -38.14497 1.000 31.54337 ?  17  LEU A C   1 
ATOM   123  O O   . LEU A 1 17  ? -7.73299  -29.31667 -38.00452 1.000 30.44923 ?  17  LEU A O   1 
ATOM   124  C CB  . LEU A 1 17  ? -5.67834  -26.78283 -37.37651 1.000 26.40249 ?  17  LEU A CB  1 
ATOM   125  C CG  . LEU A 1 17  ? -4.19243  -26.45519 -37.62581 1.000 28.42283 ?  17  LEU A CG  1 
ATOM   126  C CD1 . LEU A 1 17  ? -3.69888  -25.52871 -36.53272 1.000 25.47976 ?  17  LEU A CD1 1 
ATOM   127  C CD2 . LEU A 1 17  ? -3.32495  -27.71434 -37.73705 1.000 25.26195 ?  17  LEU A CD2 1 
ATOM   128  N N   . SER A 1 18  ? -8.77574  -27.31962 -37.93600 1.000 30.27365 ?  18  SER A N   1 
ATOM   129  C CA  . SER A 1 18  ? -10.05799 -27.93049 -37.57983 1.000 33.49866 ?  18  SER A CA  1 
ATOM   130  C C   . SER A 1 18  ? -10.55809 -28.87621 -38.66704 1.000 33.03542 ?  18  SER A C   1 
ATOM   131  O O   . SER A 1 18  ? -11.17460 -29.90070 -38.35905 1.000 37.88979 ?  18  SER A O   1 
ATOM   132  C CB  . SER A 1 18  ? -11.09848 -26.84979 -37.30880 1.000 31.18667 ?  18  SER A CB  1 
ATOM   133  O OG  . SER A 1 18  ? -11.59923 -26.38808 -38.55267 1.000 36.26212 ?  18  SER A OG  1 
ATOM   134  N N   . GLN A 1 19  ? -10.28940 -28.57014 -39.94076 1.000 30.02455 ?  19  GLN A N   1 
ATOM   135  C CA  . GLN A 1 19  ? -10.70375 -29.47020 -41.01490 1.000 31.18344 ?  19  GLN A CA  1 
ATOM   136  C C   . GLN A 1 19  ? -10.04799 -30.84496 -40.91434 1.000 36.26456 ?  19  GLN A C   1 
ATOM   137  O O   . GLN A 1 19  ? -10.61337 -31.83153 -41.39958 1.000 34.72259 ?  19  GLN A O   1 
ATOM   138  C CB  . GLN A 1 19  ? -10.36701 -28.87320 -42.37846 1.000 31.23809 ?  19  GLN A CB  1 
ATOM   139  C CG  . GLN A 1 19  ? -11.19612 -27.70059 -42.79621 1.000 32.94190 ?  19  GLN A CG  1 
ATOM   140  C CD  . GLN A 1 19  ? -10.80952 -27.24535 -44.17304 1.000 29.89208 ?  19  GLN A CD  1 
ATOM   141  O OE1 . GLN A 1 19  ? -9.62706  -27.13357 -44.49284 1.000 32.80928 ?  19  GLN A OE1 1 
ATOM   142  N NE2 . GLN A 1 19  ? -11.79339 -27.00404 -45.00648 1.000 29.32065 ?  19  GLN A NE2 1 
ATOM   143  N N   . LYS A 1 20  ? -8.83497  -30.92845 -40.36169 1.000 35.32358 ?  20  LYS A N   1 
ATOM   144  C CA  . LYS A 1 20  ? -8.14938  -32.20800 -40.18653 1.000 34.01511 ?  20  LYS A CA  1 
ATOM   145  C C   . LYS A 1 20  ? -8.40954  -32.82622 -38.82145 1.000 34.83687 ?  20  LYS A C   1 
ATOM   146  O O   . LYS A 1 20  ? -7.79019  -33.84069 -38.48679 1.000 38.15040 ?  20  LYS A O   1 
ATOM   147  C CB  . LYS A 1 20  ? -6.63739  -32.05066 -40.38737 1.000 31.79019 ?  20  LYS A CB  1 
ATOM   148  C CG  . LYS A 1 20  ? -6.22810  -31.57348 -41.77435 1.000 35.70030 ?  20  LYS A CG  1 
ATOM   149  C CD  . LYS A 1 20  ? -6.94270  -32.35841 -42.85786 1.000 40.18044 ?  20  LYS A CD  1 
ATOM   150  C CE  . LYS A 1 20  ? -5.98225  -32.77803 -43.95907 1.000 43.67627 ?  20  LYS A CE  1 
ATOM   151  N NZ  . LYS A 1 20  ? -5.56307  -31.64348 -44.82903 1.000 47.10436 ?  20  LYS A NZ  1 
ATOM   152  N N   . GLY A 1 21  ? -9.29061  -32.23494 -38.02589 1.000 35.29934 ?  21  GLY A N   1 
ATOM   153  C CA  . GLY A 1 21  ? -9.65568  -32.78203 -36.74120 1.000 39.05940 ?  21  GLY A CA  1 
ATOM   154  C C   . GLY A 1 21  ? -8.89829  -32.22229 -35.56573 1.000 42.44706 ?  21  GLY A C   1 
ATOM   155  O O   . GLY A 1 21  ? -9.05468  -32.73934 -34.45471 1.000 43.06634 ?  21  GLY A O   1 
ATOM   156  N N   . TYR A 1 22  ? -8.09216  -31.18369 -35.76993 1.000 36.59900 ?  22  TYR A N   1 
ATOM   157  C CA  . TYR A 1 22  ? -7.23604  -30.61444 -34.73958 1.000 38.95977 ?  22  TYR A CA  1 
ATOM   158  C C   . TYR A 1 22  ? -7.77662  -29.26091 -34.32431 1.000 40.74098 ?  22  TYR A C   1 
ATOM   159  O O   . TYR A 1 22  ? -8.07361  -28.42383 -35.18187 1.000 40.20887 ?  22  TYR A O   1 
ATOM   160  C CB  . TYR A 1 22  ? -5.80854  -30.44071 -35.24465 1.000 36.02078 ?  22  TYR A CB  1 
ATOM   161  C CG  . TYR A 1 22  ? -5.15426  -31.70723 -35.73095 1.000 42.52569 ?  22  TYR A CG  1 
ATOM   162  C CD1 . TYR A 1 22  ? -5.21993  -32.88090 -34.98213 1.000 43.83226 ?  22  TYR A CD1 1 
ATOM   163  C CD2 . TYR A 1 22  ? -4.43390  -31.72347 -36.92438 1.000 39.69172 ?  22  TYR A CD2 1 
ATOM   164  C CE1 . TYR A 1 22  ? -4.60450  -34.04348 -35.41799 1.000 42.34076 ?  22  TYR A CE1 1 
ATOM   165  C CE2 . TYR A 1 22  ? -3.80607  -32.88066 -37.36892 1.000 40.95225 ?  22  TYR A CE2 1 
ATOM   166  C CZ  . TYR A 1 22  ? -3.89637  -34.03598 -36.61045 1.000 43.43813 ?  22  TYR A CZ  1 
ATOM   167  O OH  . TYR A 1 22  ? -3.27348  -35.18333 -37.04379 1.000 46.25765 ?  22  TYR A OH  1 
ATOM   168  N N   . SER A 1 23  ? -7.86015  -29.02881 -33.02055 1.000 43.41252 ?  23  SER A N   1 
ATOM   169  C CA  . SER A 1 23  ? -8.43559  -27.79858 -32.48127 1.000 48.44873 ?  23  SER A CA  1 
ATOM   170  C C   . SER A 1 23  ? -7.30805  -26.96038 -31.88482 1.000 49.65026 ?  23  SER A C   1 
ATOM   171  O O   . SER A 1 23  ? -6.85908  -27.21205 -30.76191 1.000 52.53630 ?  23  SER A O   1 
ATOM   172  C CB  . SER A 1 23  ? -9.52246  -28.11492 -31.45479 1.000 49.39255 ?  23  SER A CB  1 
ATOM   173  O OG  . SER A 1 23  ? -9.76265  -27.01084 -30.60421 1.000 51.48734 ?  23  SER A OG  1 
ATOM   174  N N   . TRP A 1 24  ? -6.85499  -25.96184 -32.64472 1.000 48.90110 ?  24  TRP A N   1 
ATOM   175  C CA  . TRP A 1 24  ? -5.80825  -25.05203 -32.18479 1.000 44.91965 ?  24  TRP A CA  1 
ATOM   176  C C   . TRP A 1 24  ? -6.38569  -24.10408 -31.14255 1.000 49.80979 ?  24  TRP A C   1 
ATOM   177  O O   . TRP A 1 24  ? -7.20335  -23.23465 -31.46429 1.000 49.37673 ?  24  TRP A O   1 
ATOM   178  C CB  . TRP A 1 24  ? -5.22227  -24.27642 -33.36035 1.000 42.85586 ?  24  TRP A CB  1 
ATOM   179  C CG  . TRP A 1 24  ? -4.03836  -23.45570 -32.98296 1.000 40.31220 ?  24  TRP A CG  1 
ATOM   180  C CD1 . TRP A 1 24  ? -3.20198  -23.66790 -31.92722 1.000 45.58185 ?  24  TRP A CD1 1 
ATOM   181  C CD2 . TRP A 1 24  ? -3.55607  -22.28217 -33.65093 1.000 40.95918 ?  24  TRP A CD2 1 
ATOM   182  N NE1 . TRP A 1 24  ? -2.22371  -22.69998 -31.89552 1.000 44.98501 ?  24  TRP A NE1 1 
ATOM   183  C CE2 . TRP A 1 24  ? -2.41992  -21.83471 -32.93983 1.000 44.00436 ?  24  TRP A CE2 1 
ATOM   184  C CE3 . TRP A 1 24  ? -3.97523  -21.56415 -34.77561 1.000 38.55074 ?  24  TRP A CE3 1 
ATOM   185  C CZ2 . TRP A 1 24  ? -1.69700  -20.69734 -33.31564 1.000 37.08438 ?  24  TRP A CZ2 1 
ATOM   186  C CZ3 . TRP A 1 24  ? -3.24886  -20.43228 -35.15193 1.000 38.41441 ?  24  TRP A CZ3 1 
ATOM   187  C CH2 . TRP A 1 24  ? -2.12316  -20.01644 -34.42687 1.000 38.89343 ?  24  TRP A CH2 1 
ATOM   188  N N   . SER A 1 25  ? -5.96379  -24.27171 -29.89228 1.000 51.66093 ?  25  SER A N   1 
ATOM   189  C CA  . SER A 1 25  ? -6.47432  -23.44643 -28.80562 1.000 55.18673 ?  25  SER A CA  1 
ATOM   190  C C   . SER A 1 25  ? -5.96306  -22.01890 -28.95367 1.000 52.75543 ?  25  SER A C   1 
ATOM   191  O O   . SER A 1 25  ? -4.75040  -21.78644 -29.00812 1.000 53.68534 ?  25  SER A O   1 
ATOM   192  C CB  . SER A 1 25  ? -6.05276  -24.02914 -27.45798 1.000 58.64599 ?  25  SER A CB  1 
ATOM   193  O OG  . SER A 1 25  ? -4.64039  -24.02153 -27.32695 1.000 64.31240 ?  25  SER A OG  1 
ATOM   194  N N   . GLN A 1 26  ? -6.88532  -21.06514 -29.03905 1.000 52.07761 ?  26  GLN A N   1 
ATOM   195  C CA  . GLN A 1 26  ? -6.51777  -19.66027 -28.99057 1.000 52.67508 ?  26  GLN A CA  1 
ATOM   196  C C   . GLN A 1 26  ? -6.84109  -19.14420 -27.59761 1.000 46.65680 ?  26  GLN A C   1 
ATOM   197  O O   . GLN A 1 26  ? -8.02246  -19.12496 -27.21514 1.000 42.88613 ?  26  GLN A O   1 
ATOM   198  C CB  . GLN A 1 26  ? -7.26635  -18.85623 -30.05436 1.000 53.63322 ?  26  GLN A CB  1 
ATOM   199  C CG  . GLN A 1 26  ? -7.17516  -19.44405 -31.46702 1.000 56.29938 ?  26  GLN A CG  1 
ATOM   200  C CD  . GLN A 1 26  ? -8.43516  -20.18906 -31.87583 1.000 59.92921 ?  26  GLN A CD  1 
ATOM   201  O OE1 . GLN A 1 26  ? -9.01858  -20.92818 -31.07836 1.000 62.97072 ?  26  GLN A OE1 1 
ATOM   202  N NE2 . GLN A 1 26  ? -8.87435  -19.98199 -33.11897 1.000 64.59463 ?  26  GLN A NE2 1 
ATOM   203  N N   . PRO A 1 27  ? -5.85006  -18.74719 -26.79523 1.000 48.67713 ?  82  PRO A N   1 
ATOM   204  C CA  . PRO A 1 27  ? -6.17590  -18.25749 -25.44375 1.000 45.22840 ?  82  PRO A CA  1 
ATOM   205  C C   . PRO A 1 27  ? -7.05456  -17.01440 -25.45022 1.000 43.14469 ?  82  PRO A C   1 
ATOM   206  O O   . PRO A 1 27  ? -7.84706  -16.82860 -24.51282 1.000 39.90339 ?  82  PRO A O   1 
ATOM   207  C CB  . PRO A 1 27  ? -4.79754  -17.99329 -24.81697 1.000 47.04988 ?  82  PRO A CB  1 
ATOM   208  C CG  . PRO A 1 27  ? -3.84844  -17.88902 -25.96775 1.000 47.75226 ?  82  PRO A CG  1 
ATOM   209  C CD  . PRO A 1 27  ? -4.40041  -18.74265 -27.06658 1.000 46.62743 ?  82  PRO A CD  1 
ATOM   210  N N   . MET A 1 28  ? -6.97417  -16.17090 -26.48958 1.000 39.98619 ?  83  MET A N   1 
ATOM   211  C CA  . MET A 1 28  ? -7.86252  -15.01179 -26.53698 1.000 36.11748 ?  83  MET A CA  1 
ATOM   212  C C   . MET A 1 28  ? -9.31382  -15.41148 -26.79672 1.000 31.77514 ?  83  MET A C   1 
ATOM   213  O O   . MET A 1 28  ? -10.21850 -14.62530 -26.50042 1.000 30.98681 ?  83  MET A O   1 
ATOM   214  C CB  . MET A 1 28  ? -7.40426  -14.00851 -27.59962 1.000 37.25232 ?  83  MET A CB  1 
ATOM   215  C CG  . MET A 1 28  ? -6.10265  -13.24640 -27.26909 1.000 45.42266 ?  83  MET A CG  1 
ATOM   216  S SD  . MET A 1 28  ? -6.10572  -12.27794 -25.72536 1.000 52.03610 ?  83  MET A SD  1 
ATOM   217  C CE  . MET A 1 28  ? -5.08019  -13.32275 -24.66354 1.000 47.12290 ?  83  MET A CE  1 
ATOM   218  N N   . ALA A 1 29  ? -9.55980  -16.60616 -27.34264 1.000 32.35082 ?  84  ALA A N   1 
ATOM   219  C CA  . ALA A 1 29  ? -10.93632 -17.08459 -27.47936 1.000 31.46604 ?  84  ALA A CA  1 
ATOM   220  C C   . ALA A 1 29  ? -11.60934 -17.23820 -26.11539 1.000 30.19282 ?  84  ALA A C   1 
ATOM   221  O O   . ALA A 1 29  ? -12.78096 -16.87955 -25.94462 1.000 30.01669 ?  84  ALA A O   1 
ATOM   222  C CB  . ALA A 1 29  ? -10.95448 -18.41018 -28.23853 1.000 38.31196 ?  84  ALA A CB  1 
ATOM   223  N N   . ALA A 1 30  ? -10.87629 -17.74698 -25.12228 1.000 28.03018 ?  85  ALA A N   1 
ATOM   224  C CA  . ALA A 1 30  ? -11.43518 -17.86335 -23.77968 1.000 28.69433 ?  85  ALA A CA  1 
ATOM   225  C C   . ALA A 1 30  ? -11.66843 -16.49193 -23.15841 1.000 27.29739 ?  85  ALA A C   1 
ATOM   226  O O   . ALA A 1 30  ? -12.64178 -16.29813 -22.41953 1.000 23.70291 ?  85  ALA A O   1 
ATOM   227  C CB  . ALA A 1 30  ? -10.50689 -18.69998 -22.89761 1.000 31.59563 ?  85  ALA A CB  1 
ATOM   228  N N   . VAL A 1 31  ? -10.77201 -15.53939 -23.43049 1.000 23.54509 ?  86  VAL A N   1 
ATOM   229  C CA  . VAL A 1 31  ? -10.95267 -14.17759 -22.93802 1.000 25.50556 ?  86  VAL A CA  1 
ATOM   230  C C   . VAL A 1 31  ? -12.20718 -13.56366 -23.53430 1.000 23.32444 ?  86  VAL A C   1 
ATOM   231  O O   . VAL A 1 31  ? -13.00422 -12.95432 -22.82202 1.000 21.98214 ?  86  VAL A O   1 
ATOM   232  C CB  . VAL A 1 31  ? -9.72138  -13.31248 -23.24963 1.000 23.93715 ?  86  VAL A CB  1 
ATOM   233  C CG1 . VAL A 1 31  ? -9.95058  -11.88580 -22.75064 1.000 21.33962 ?  86  VAL A CG1 1 
ATOM   234  C CG2 . VAL A 1 31  ? -8.47490  -13.93693 -22.62423 1.000 28.06766 ?  86  VAL A CG2 1 
ATOM   235  N N   . LYS A 1 32  ? -12.37396 -13.68089 -24.85455 1.000 19.74024 ?  87  LYS A N   1 
ATOM   236  C CA  . LYS A 1 32  ? -13.54684 -13.10385 -25.51082 1.000 23.61656 ?  87  LYS A CA  1 
ATOM   237  C C   . LYS A 1 32  ? -14.84062 -13.67907 -24.93808 1.000 23.07402 ?  87  LYS A C   1 
ATOM   238  O O   . LYS A 1 32  ? -15.78077 -12.93476 -24.63667 1.000 21.72749 ?  87  LYS A O   1 
ATOM   239  C CB  . LYS A 1 32  ? -13.45784 -13.33466 -27.02314 1.000 23.41788 ?  87  LYS A CB  1 
ATOM   240  C CG  . LYS A 1 32  ? -12.44353 -12.43306 -27.73696 1.000 22.94557 ?  87  LYS A CG  1 
ATOM   241  C CD  . LYS A 1 32  ? -12.19099 -12.91189 -29.15099 1.000 27.78503 ?  87  LYS A CD  1 
ATOM   242  C CE  . LYS A 1 32  ? -11.02817 -12.17366 -29.79392 1.000 34.30891 ?  87  LYS A CE  1 
ATOM   243  N NZ  . LYS A 1 32  ? -10.95171 -12.50680 -31.23577 1.000 36.52332 ?  87  LYS A NZ  1 
ATOM   244  N N   . GLN A 1 33  ? -14.89627 -14.99950 -24.74914 1.000 22.02771 ?  88  GLN A N   1 
ATOM   245  C CA  . GLN A 1 33  ? -16.09056 -15.62966 -24.19283 1.000 21.51593 ?  88  GLN A CA  1 
ATOM   246  C C   . GLN A 1 33  ? -16.34387 -15.18420 -22.75745 1.000 23.12782 ?  88  GLN A C   1 
ATOM   247  O O   . GLN A 1 33  ? -17.48935 -14.93228 -22.37155 1.000 23.01386 ?  88  GLN A O   1 
ATOM   248  C CB  . GLN A 1 33  ? -15.96309 -17.15915 -24.26476 1.000 22.35958 ?  88  GLN A CB  1 
ATOM   249  C CG  . GLN A 1 33  ? -17.22770 -17.90107 -23.79681 1.000 27.49770 ?  88  GLN A CG  1 
ATOM   250  C CD  . GLN A 1 33  ? -18.42857 -17.64476 -24.70588 1.000 32.76007 ?  88  GLN A CD  1 
ATOM   251  O OE1 . GLN A 1 33  ? -18.29104 -17.58039 -25.93517 1.000 41.19003 ?  88  GLN A OE1 1 
ATOM   252  N NE2 . GLN A 1 33  ? -19.61040 -17.48152 -24.10456 1.000 32.43523 ?  88  GLN A NE2 1 
ATOM   253  N N   . ALA A 1 34  ? -15.29940 -15.07843 -21.94084 1.000 19.97884 ?  89  ALA A N   1 
ATOM   254  C CA  . ALA A 1 34  ? -15.52688 -14.67785 -20.55197 1.000 22.52103 ?  89  ALA A CA  1 
ATOM   255  C C   . ALA A 1 34  ? -16.00115 -13.22936 -20.46495 1.000 22.53690 ?  89  ALA A C   1 
ATOM   256  O O   . ALA A 1 34  ? -16.84485 -12.89480 -19.62235 1.000 21.14235 ?  89  ALA A O   1 
ATOM   257  C CB  . ALA A 1 34  ? -14.25392 -14.88072 -19.72287 1.000 23.51967 ?  89  ALA A CB  1 
ATOM   258  N N   . LEU A 1 35  ? -15.47613 -12.36358 -21.33751 1.000 20.94849 ?  90  LEU A N   1 
ATOM   259  C CA  . LEU A 1 35  ? -15.89150 -10.96233 -21.35604 1.000 20.50302 ?  90  LEU A CA  1 
ATOM   260  C C   . LEU A 1 35  ? -17.33861 -10.81844 -21.79409 1.000 19.61231 ?  90  LEU A C   1 
ATOM   261  O O   . LEU A 1 35  ? -18.08260 -10.00352 -21.22949 1.000 20.06291 ?  90  LEU A O   1 
ATOM   262  C CB  . LEU A 1 35  ? -14.97527 -10.16276 -22.28454 1.000 22.44585 ?  90  LEU A CB  1 
ATOM   263  C CG  . LEU A 1 35  ? -14.55162 -8.72225  -21.98295 1.000 29.58189 ?  90  LEU A CG  1 
ATOM   264  C CD1 . LEU A 1 35  ? -14.45655 -8.44519  -20.49393 1.000 28.76894 ?  90  LEU A CD1 1 
ATOM   265  C CD2 . LEU A 1 35  ? -13.21137 -8.43026  -22.67859 1.000 25.93836 ?  90  LEU A CD2 1 
ATOM   266  N N   . ARG A 1 36  ? -17.75880 -11.59576 -22.80126 1.000 20.58504 ?  91  ARG A N   1 
ATOM   267  C CA  . ARG A 1 36  ? -19.16047 -11.58363 -23.23325 1.000 22.29983 ?  91  ARG A CA  1 
ATOM   268  C C   . ARG A 1 36  ? -20.09041 -11.96834 -22.09289 1.000 22.17877 ?  91  ARG A C   1 
ATOM   269  O O   . ARG A 1 36  ? -21.10717 -11.30001 -21.84112 1.000 20.90224 ?  91  ARG A O   1 
ATOM   270  C CB  . ARG A 1 36  ? -19.36716 -12.55396 -24.39788 1.000 22.56618 ?  91  ARG A CB  1 
ATOM   271  C CG  . ARG A 1 36  ? -18.76767 -12.12825 -25.70042 1.000 23.38036 ?  91  ARG A CG  1 
ATOM   272  C CD  . ARG A 1 36  ? -18.86251 -13.25798 -26.72800 1.000 27.30645 ?  91  ARG A CD  1 
ATOM   273  N NE  . ARG A 1 36  ? -18.36754 -12.79121 -28.02278 1.000 27.45593 ?  91  ARG A NE  1 
ATOM   274  C CZ  . ARG A 1 36  ? -18.65052 -13.35676 -29.19435 1.000 32.89883 ?  91  ARG A CZ  1 
ATOM   275  N NH1 . ARG A 1 36  ? -19.42163 -14.43608 -29.25312 1.000 31.76783 ?  91  ARG A NH1 1 
ATOM   276  N NH2 . ARG A 1 36  ? -18.14328 -12.84678 -30.31348 1.000 35.93152 ?  91  ARG A NH2 1 
ATOM   277  N N   . GLU A 1 37  ? -19.77620 -13.07644 -21.41500 1.000 19.61044 ?  92  GLU A N   1 
ATOM   278  C CA  . GLU A 1 37  ? -20.62054 -13.56442 -20.32890 1.000 20.03438 ?  92  GLU A CA  1 
ATOM   279  C C   . GLU A 1 37  ? -20.62237 -12.61390 -19.14306 1.000 22.23353 ?  92  GLU A C   1 
ATOM   280  O O   . GLU A 1 37  ? -21.67752 -12.37177 -18.53811 1.000 20.59905 ?  92  GLU A O   1 
ATOM   281  C CB  . GLU A 1 37  ? -20.16794 -14.95957 -19.90562 1.000 25.06676 ?  92  GLU A CB  1 
ATOM   282  C CG  . GLU A 1 37  ? -20.27211 -15.98415 -21.03367 1.000 24.63668 ?  92  GLU A CG  1 
ATOM   283  C CD  . GLU A 1 37  ? -19.98015 -17.38746 -20.54754 1.000 36.77666 ?  92  GLU A CD  1 
ATOM   284  O OE1 . GLU A 1 37  ? -20.02444 -17.60855 -19.30887 1.000 39.64012 ?  92  GLU A OE1 1 
ATOM   285  O OE2 . GLU A 1 37  ? -19.69756 -18.26022 -21.40102 1.000 39.58263 -1 92  GLU A OE2 1 
ATOM   286  N N   . ALA A 1 38  ? -19.45804 -12.06425 -18.79239 1.000 19.25163 ?  93  ALA A N   1 
ATOM   287  C CA  . ALA A 1 38  ? -19.38930 -11.15074 -17.66349 1.000 19.93990 ?  93  ALA A CA  1 
ATOM   288  C C   . ALA A 1 38  ? -20.17653 -9.88132  -17.95198 1.000 19.59530 ?  93  ALA A C   1 
ATOM   289  O O   . ALA A 1 38  ? -20.86506 -9.35745  -17.06975 1.000 22.30388 ?  93  ALA A O   1 
ATOM   290  C CB  . ALA A 1 38  ? -17.92416 -10.81643 -17.33900 1.000 20.42488 ?  93  ALA A CB  1 
ATOM   291  N N   . GLY A 1 39  ? -20.08509 -9.37356  -19.18100 1.000 15.44220 ?  94  GLY A N   1 
ATOM   292  C CA  . GLY A 1 39  ? -20.85914 -8.19416  -19.53802 1.000 20.44809 ?  94  GLY A CA  1 
ATOM   293  C C   . GLY A 1 39  ? -22.35951 -8.45837  -19.48958 1.000 22.30580 ?  94  GLY A C   1 
ATOM   294  O O   . GLY A 1 39  ? -23.12751 -7.63358  -18.99357 1.000 20.85738 ?  94  GLY A O   1 
ATOM   295  N N   . ASP A 1 40  ? -22.79044 -9.61371  -20.00366 1.000 20.74508 ?  95  ASP A N   1 
ATOM   296  C CA  . ASP A 1 40  ? -24.19912 -9.98616  -19.88441 1.000 20.57959 ?  95  ASP A CA  1 
ATOM   297  C C   . ASP A 1 40  ? -24.62958 -10.02881 -18.42626 1.000 23.12692 ?  95  ASP A C   1 
ATOM   298  O O   . ASP A 1 40  ? -25.68528 -9.50719  -18.06948 1.000 22.47267 ?  95  ASP A O   1 
ATOM   299  C CB  . ASP A 1 40  ? -24.44595 -11.33721 -20.54249 1.000 22.63213 ?  95  ASP A CB  1 
ATOM   300  C CG  . ASP A 1 40  ? -24.43798 -11.25130 -22.03391 1.000 25.59206 ?  95  ASP A CG  1 
ATOM   301  O OD1 . ASP A 1 40  ? -24.44286 -10.10149 -22.53756 1.000 26.62619 ?  95  ASP A OD1 1 
ATOM   302  O OD2 . ASP A 1 40  ? -24.40660 -12.32190 -22.69808 1.000 27.46490 -1 95  ASP A OD2 1 
ATOM   303  N N   . GLU A 1 41  ? -23.82079 -10.65670 -17.56492 1.000 23.55031 ?  96  GLU A N   1 
ATOM   304  C CA  . GLU A 1 41  ? -24.17559 -10.75410 -16.15270 1.000 24.83123 ?  96  GLU A CA  1 
ATOM   305  C C   . GLU A 1 41  ? -24.17652 -9.38624  -15.47533 1.000 22.55001 ?  96  GLU A C   1 
ATOM   306  O O   . GLU A 1 41  ? -25.06004 -9.10069  -14.65731 1.000 22.72494 ?  96  GLU A O   1 
ATOM   307  C CB  . GLU A 1 41  ? -23.22102 -11.72185 -15.44001 1.000 25.06109 ?  96  GLU A CB  1 
ATOM   308  C CG  . GLU A 1 41  ? -23.33410 -11.71395 -13.90298 1.000 30.57053 ?  96  GLU A CG  1 
ATOM   309  C CD  . GLU A 1 41  ? -24.55512 -12.46633 -13.33809 1.000 44.65192 ?  96  GLU A CD  1 
ATOM   310  O OE1 . GLU A 1 41  ? -25.40713 -12.98800 -14.11276 1.000 43.79813 ?  96  GLU A OE1 1 
ATOM   311  O OE2 . GLU A 1 41  ? -24.65953 -12.53886 -12.09056 1.000 51.25346 -1 96  GLU A OE2 1 
ATOM   312  N N   . PHE A 1 42  ? -23.19598 -8.52503  -15.79193 1.000 23.04273 ?  97  PHE A N   1 
ATOM   313  C CA  . PHE A 1 42  ? -23.17628 -7.18242  -15.20776 1.000 20.26583 ?  97  PHE A CA  1 
ATOM   314  C C   . PHE A 1 42  ? -24.44953 -6.41814  -15.54700 1.000 20.73318 ?  97  PHE A C   1 
ATOM   315  O O   . PHE A 1 42  ? -25.06968 -5.80837  -14.66938 1.000 20.27839 ?  97  PHE A O   1 
ATOM   316  C CB  . PHE A 1 42  ? -21.95174 -6.39349  -15.68835 1.000 18.21448 ?  97  PHE A CB  1 
ATOM   317  C CG  . PHE A 1 42  ? -21.99175 -4.92145  -15.33691 1.000 18.09341 ?  97  PHE A CG  1 
ATOM   318  C CD1 . PHE A 1 42  ? -21.97978 -4.51012  -14.00959 1.000 17.44848 ?  97  PHE A CD1 1 
ATOM   319  C CD2 . PHE A 1 42  ? -22.03371 -3.94990  -16.33179 1.000 17.76462 ?  97  PHE A CD2 1 
ATOM   320  C CE1 . PHE A 1 42  ? -22.01986 -3.15665  -13.68338 1.000 17.44706 ?  97  PHE A CE1 1 
ATOM   321  C CE2 . PHE A 1 42  ? -22.05825 -2.58580  -16.00594 1.000 17.03237 ?  97  PHE A CE2 1 
ATOM   322  C CZ  . PHE A 1 42  ? -22.05682 -2.20302  -14.68504 1.000 17.80166 ?  97  PHE A CZ  1 
ATOM   323  N N   . GLU A 1 43  ? -24.86018 -6.45242  -16.82058 1.000 18.59567 ?  98  GLU A N   1 
ATOM   324  C CA  . GLU A 1 43  ? -26.00309 -5.65041  -17.26512 1.000 21.60084 ?  98  GLU A CA  1 
ATOM   325  C C   . GLU A 1 43  ? -27.32489 -6.14538  -16.69440 1.000 24.86869 ?  98  GLU A C   1 
ATOM   326  O O   . GLU A 1 43  ? -28.25912 -5.35337  -16.52184 1.000 21.13615 ?  98  GLU A O   1 
ATOM   327  C CB  . GLU A 1 43  ? -26.07288 -5.64539  -18.79429 1.000 21.08714 ?  98  GLU A CB  1 
ATOM   328  C CG  . GLU A 1 43  ? -24.78500 -4.99820  -19.42278 1.000 19.49179 ?  98  GLU A CG  1 
ATOM   329  C CD  . GLU A 1 43  ? -24.60079 -5.34917  -20.89981 1.000 23.93334 ?  98  GLU A CD  1 
ATOM   330  O OE1 . GLU A 1 43  ? -25.58403 -5.77804  -21.53961 1.000 24.63178 ?  98  GLU A OE1 1 
ATOM   331  O OE2 . GLU A 1 43  ? -23.46928 -5.20370  -21.41897 1.000 24.36151 -1 98  GLU A OE2 1 
ATOM   332  N N   . LEU A 1 44  ? -27.43153 -7.44178  -16.43191 1.000 19.22527 ?  99  LEU A N   1 
ATOM   333  C CA  . LEU A 1 44  ? -28.63932 -8.04374  -15.87967 1.000 20.33795 ?  99  LEU A CA  1 
ATOM   334  C C   . LEU A 1 44  ? -28.64433 -8.01961  -14.35456 1.000 22.35723 ?  99  LEU A C   1 
ATOM   335  O O   . LEU A 1 44  ? -29.59316 -7.52471  -13.73787 1.000 27.83452 ?  99  LEU A O   1 
ATOM   336  C CB  . LEU A 1 44  ? -28.78036 -9.48231  -16.38755 1.000 22.61568 ?  99  LEU A CB  1 
ATOM   337  C CG  . LEU A 1 44  ? -29.88924 -10.29647 -15.70062 1.000 27.58965 ?  99  LEU A CG  1 
ATOM   338  C CD1 . LEU A 1 44  ? -31.25753 -9.81018  -16.15873 1.000 26.57282 ?  99  LEU A CD1 1 
ATOM   339  C CD2 . LEU A 1 44  ? -29.72215 -11.78170 -15.94479 1.000 35.43249 ?  99  LEU A CD2 1 
ATOM   340  N N   . ARG A 1 45  ? -27.59825 -8.53835  -13.72218 1.000 25.16682 ?  100 ARG A N   1 
ATOM   341  C CA  . ARG A 1 45  ? -27.59593 -8.61876  -12.26948 1.000 24.57787 ?  100 ARG A CA  1 
ATOM   342  C C   . ARG A 1 45  ? -27.32486 -7.27766  -11.60179 1.000 24.07736 ?  100 ARG A C   1 
ATOM   343  O O   . ARG A 1 45  ? -27.72473 -7.08438  -10.44862 1.000 27.27107 ?  100 ARG A O   1 
ATOM   344  C CB  . ARG A 1 45  ? -26.56491 -9.64949  -11.79802 1.000 29.01419 ?  100 ARG A CB  1 
ATOM   345  C CG  . ARG A 1 45  ? -26.59691 -9.87077  -10.28771 1.000 39.24328 ?  100 ARG A CG  1 
ATOM   346  C CD  . ARG A 1 45  ? -26.06715 -11.24083 -9.90035  1.000 47.74958 ?  100 ARG A CD  1 
ATOM   347  N NE  . ARG A 1 45  ? -25.35082 -11.23955 -8.61598  1.000 52.87327 ?  100 ARG A NE  1 
ATOM   348  C CZ  . ARG A 1 45  ? -24.46280 -12.17087 -8.26111  1.000 59.95204 ?  100 ARG A CZ  1 
ATOM   349  N NH1 . ARG A 1 45  ? -24.16413 -13.14156 -9.11303  1.000 60.32256 ?  100 ARG A NH1 1 
ATOM   350  N NH2 . ARG A 1 45  ? -23.84674 -12.11972 -7.08012  1.000 57.19181 ?  100 ARG A NH2 1 
ATOM   351  N N   . TYR A 1 46  ? -26.64975 -6.34739  -12.27859 1.000 21.92336 ?  101 TYR A N   1 
ATOM   352  C CA  . TYR A 1 46  ? -26.35534 -5.05118  -11.67401 1.000 19.02932 ?  101 TYR A CA  1 
ATOM   353  C C   . TYR A 1 46  ? -26.91335 -3.94761  -12.55858 1.000 24.26532 ?  101 TYR A C   1 
ATOM   354  O O   . TYR A 1 46  ? -26.19160 -3.00837  -12.90556 1.000 22.24271 ?  101 TYR A O   1 
ATOM   355  C CB  . TYR A 1 46  ? -24.84280 -4.86692  -11.44876 1.000 21.75176 ?  101 TYR A CB  1 
ATOM   356  C CG  . TYR A 1 46  ? -24.33181 -5.99777  -10.59422 1.000 25.63354 ?  101 TYR A CG  1 
ATOM   357  C CD1 . TYR A 1 46  ? -24.60620 -6.02329  -9.22925  1.000 28.66037 ?  101 TYR A CD1 1 
ATOM   358  C CD2 . TYR A 1 46  ? -23.68519 -7.08541  -11.15791 1.000 25.06338 ?  101 TYR A CD2 1 
ATOM   359  C CE1 . TYR A 1 46  ? -24.21013 -7.07298  -8.44520  1.000 33.10323 ?  101 TYR A CE1 1 
ATOM   360  C CE2 . TYR A 1 46  ? -23.25997 -8.14935  -10.36764 1.000 29.84545 ?  101 TYR A CE2 1 
ATOM   361  C CZ  . TYR A 1 46  ? -23.54084 -8.13606  -9.01312  1.000 30.89836 ?  101 TYR A CZ  1 
ATOM   362  O OH  . TYR A 1 46  ? -23.14547 -9.17939  -8.20530  1.000 40.37739 ?  101 TYR A OH  1 
ATOM   363  N N   . ARG A 1 47  ? -28.19148 -4.04620  -12.93504 1.000 21.50693 ?  102 ARG A N   1 
ATOM   364  C CA  . ARG A 1 47  ? -28.71993 -3.09547  -13.91201 1.000 24.65200 ?  102 ARG A CA  1 
ATOM   365  C C   . ARG A 1 47  ? -28.66116 -1.64783  -13.41996 1.000 21.06118 ?  102 ARG A C   1 
ATOM   366  O O   . ARG A 1 47  ? -28.48784 -0.73192  -14.22951 1.000 20.61422 ?  102 ARG A O   1 
ATOM   367  C CB  . ARG A 1 47  ? -30.15694 -3.44009  -14.31388 1.000 23.45535 ?  102 ARG A CB  1 
ATOM   368  C CG  . ARG A 1 47  ? -30.39682 -2.89898  -15.72941 1.000 31.15114 ?  102 ARG A CG  1 
ATOM   369  C CD  . ARG A 1 47  ? -31.81767 -2.82203  -16.13668 1.000 29.39577 ?  102 ARG A CD  1 
ATOM   370  N NE  . ARG A 1 47  ? -32.04099 -1.67972  -17.01528 1.000 29.52323 ?  102 ARG A NE  1 
ATOM   371  C CZ  . ARG A 1 47  ? -31.74646 -1.63047  -18.30997 1.000 29.57570 ?  102 ARG A CZ  1 
ATOM   372  N NH1 . ARG A 1 47  ? -31.16826 -2.67036  -18.92796 1.000 23.48130 ?  102 ARG A NH1 1 
ATOM   373  N NH2 . ARG A 1 47  ? -32.02821 -0.51491  -18.97961 1.000 22.87102 ?  102 ARG A NH2 1 
ATOM   374  N N   . ARG A 1 48  ? -28.78473 -1.41029  -12.11443 1.000 23.15634 ?  103 ARG A N   1 
ATOM   375  C CA  . ARG A 1 48  ? -28.71833 -0.02859  -11.63469 1.000 27.86397 ?  103 ARG A CA  1 
ATOM   376  C C   . ARG A 1 48  ? -27.31780 0.55183   -11.80764 1.000 20.93671 ?  103 ARG A C   1 
ATOM   377  O O   . ARG A 1 48  ? -27.16109 1.73032   -12.13310 1.000 26.16757 ?  103 ARG A O   1 
ATOM   378  C CB  . ARG A 1 48  ? -29.15382 0.05296   -10.16402 1.000 29.53398 ?  103 ARG A CB  1 
ATOM   379  C CG  . ARG A 1 48  ? -29.09992 1.47062   -9.55314  1.000 37.51169 ?  103 ARG A CG  1 
ATOM   380  C CD  . ARG A 1 48  ? -30.26974 2.34850   -9.96291  1.000 50.94224 ?  103 ARG A CD  1 
ATOM   381  N NE  . ARG A 1 48  ? -31.46530 2.05610   -9.15221  1.000 55.16083 ?  103 ARG A NE  1 
ATOM   382  C CZ  . ARG A 1 48  ? -32.52922 1.36913   -9.57246  1.000 46.62563 ?  103 ARG A CZ  1 
ATOM   383  N NH1 . ARG A 1 48  ? -32.56679 0.90470   -10.81101 1.000 50.06745 ?  103 ARG A NH1 1 
ATOM   384  N NH2 . ARG A 1 48  ? -33.55651 1.15799   -8.75797  1.000 52.02714 ?  103 ARG A NH2 1 
ATOM   385  N N   . ALA A 1 49  ? -26.28867 -0.25367  -11.56099 1.000 21.76838 ?  104 ALA A N   1 
ATOM   386  C CA  . ALA A 1 49  ? -24.91858 0.18667   -11.80408 1.000 24.56562 ?  104 ALA A CA  1 
ATOM   387  C C   . ALA A 1 49  ? -24.67902 0.42549   -13.28444 1.000 22.07458 ?  104 ALA A C   1 
ATOM   388  O O   . ALA A 1 49  ? -23.97688 1.37073   -13.67585 1.000 23.55952 ?  104 ALA A O   1 
ATOM   389  C CB  . ALA A 1 49  ? -23.94570 -0.86921  -11.28134 1.000 19.86187 ?  104 ALA A CB  1 
ATOM   390  N N   . PHE A 1 50  ? -25.21725 -0.45758  -14.11848 1.000 18.07827 ?  105 PHE A N   1 
ATOM   391  C CA  . PHE A 1 50  ? -25.04879 -0.35173  -15.56195 1.000 17.80843 ?  105 PHE A CA  1 
ATOM   392  C C   . PHE A 1 50  ? -25.72760 0.90384   -16.10353 1.000 22.35059 ?  105 PHE A C   1 
ATOM   393  O O   . PHE A 1 50  ? -25.10688 1.69217   -16.82874 1.000 20.71690 ?  105 PHE A O   1 
ATOM   394  C CB  . PHE A 1 50  ? -25.61248 -1.61449  -16.20243 1.000 17.78870 ?  105 PHE A CB  1 
ATOM   395  C CG  . PHE A 1 50  ? -25.70968 -1.56920  -17.70319 1.000 19.37866 ?  105 PHE A CG  1 
ATOM   396  C CD1 . PHE A 1 50  ? -24.59676 -1.31575  -18.48177 1.000 20.40216 ?  105 PHE A CD1 1 
ATOM   397  C CD2 . PHE A 1 50  ? -26.90894 -1.85752  -18.33436 1.000 23.01592 ?  105 PHE A CD2 1 
ATOM   398  C CE1 . PHE A 1 50  ? -24.68386 -1.29730  -19.86396 1.000 21.66827 ?  105 PHE A CE1 1 
ATOM   399  C CE2 . PHE A 1 50  ? -27.00419 -1.85320  -19.71194 1.000 25.62746 ?  105 PHE A CE2 1 
ATOM   400  C CZ  . PHE A 1 50  ? -25.87816 -1.57702  -20.48372 1.000 22.75151 ?  105 PHE A CZ  1 
ATOM   401  N N   . SER A 1 51  ? -27.00529 1.10760   -15.76088 1.000 22.04250 ?  106 SER A N   1 
ATOM   402  C CA  . SER A 1 51  ? -27.73025 2.27142   -16.28345 1.000 22.03355 ?  106 SER A CA  1 
ATOM   403  C C   . SER A 1 51  ? -27.21944 3.57907   -15.67243 1.000 22.94315 ?  106 SER A C   1 
ATOM   404  O O   . SER A 1 51  ? -27.28455 4.62546   -16.32414 1.000 23.31128 ?  106 SER A O   1 
ATOM   405  C CB  . SER A 1 51  ? -29.24160 2.10901   -16.06358 1.000 25.10078 ?  106 SER A CB  1 
ATOM   406  O OG  . SER A 1 51  ? -29.57026 2.05611   -14.68732 1.000 24.18062 ?  106 SER A OG  1 
ATOM   407  N N   . ASP A 1 52  ? -26.66432 3.53769   -14.45762 1.000 21.19349 ?  107 ASP A N   1 
ATOM   408  C CA  . ASP A 1 52  ? -26.05094 4.73199   -13.89080 1.000 25.84133 ?  107 ASP A CA  1 
ATOM   409  C C   . ASP A 1 52  ? -24.85932 5.18221   -14.73205 1.000 27.71359 ?  107 ASP A C   1 
ATOM   410  O O   . ASP A 1 52  ? -24.65718 6.38382   -14.94564 1.000 24.59147 ?  107 ASP A O   1 
ATOM   411  C CB  . ASP A 1 52  ? -25.62196 4.46975   -12.44607 1.000 29.06297 ?  107 ASP A CB  1 
ATOM   412  C CG  . ASP A 1 52  ? -25.13292 5.73521   -11.73694 1.000 42.07653 ?  107 ASP A CG  1 
ATOM   413  O OD1 . ASP A 1 52  ? -25.97649 6.46538   -11.17039 1.000 44.26500 ?  107 ASP A OD1 1 
ATOM   414  O OD2 . ASP A 1 52  ? -23.90122 6.00181   -11.73565 1.000 40.05564 -1 107 ASP A OD2 1 
ATOM   415  N N   . LEU A 1 53  ? -24.08216 4.22872   -15.25369 1.000 22.54023 ?  108 LEU A N   1 
ATOM   416  C CA  . LEU A 1 53  ? -22.95457 4.57696   -16.11836 1.000 21.96709 ?  108 LEU A CA  1 
ATOM   417  C C   . LEU A 1 53  ? -23.43080 5.06437   -17.49020 1.000 23.98673 ?  108 LEU A C   1 
ATOM   418  O O   . LEU A 1 53  ? -23.00308 6.12151   -17.96614 1.000 23.69895 ?  108 LEU A O   1 
ATOM   419  C CB  . LEU A 1 53  ? -22.01897 3.36440   -16.24649 1.000 27.23638 ?  108 LEU A CB  1 
ATOM   420  C CG  . LEU A 1 53  ? -20.60338 3.52970   -16.81154 1.000 26.82030 ?  108 LEU A CG  1 
ATOM   421  C CD1 . LEU A 1 53  ? -19.86362 4.62932   -16.10086 1.000 24.86598 ?  108 LEU A CD1 1 
ATOM   422  C CD2 . LEU A 1 53  ? -19.86012 2.22107   -16.65650 1.000 25.63526 ?  108 LEU A CD2 1 
ATOM   423  N N   . THR A 1 54  ? -24.34985 4.33396   -18.12684 1.000 21.76652 ?  109 THR A N   1 
ATOM   424  C CA  . THR A 1 54  ? -24.79850 4.73059   -19.46416 1.000 25.50534 ?  109 THR A CA  1 
ATOM   425  C C   . THR A 1 54  ? -25.51513 6.08230   -19.47335 1.000 26.95387 ?  109 THR A C   1 
ATOM   426  O O   . THR A 1 54  ? -25.52441 6.77247   -20.50220 1.000 25.55231 ?  109 THR A O   1 
ATOM   427  C CB  . THR A 1 54  ? -25.70757 3.65278   -20.05679 1.000 26.06921 ?  109 THR A CB  1 
ATOM   428  O OG1 . THR A 1 54  ? -26.92706 3.55335   -19.28993 1.000 25.94263 ?  109 THR A OG1 1 
ATOM   429  C CG2 . THR A 1 54  ? -24.98497 2.31647   -20.05177 1.000 24.66562 ?  109 THR A CG2 1 
ATOM   430  N N   . SER A 1 55  ? -26.11971 6.48445   -18.35561 1.000 24.90203 ?  110 SER A N   1 
ATOM   431  C CA  . SER A 1 55  ? -26.78060 7.78704   -18.32963 1.000 24.99001 ?  110 SER A CA  1 
ATOM   432  C C   . SER A 1 55  ? -25.80354 8.96088   -18.37263 1.000 27.54278 ?  110 SER A C   1 
ATOM   433  O O   . SER A 1 55  ? -26.24439 10.09138  -18.58946 1.000 27.63333 ?  110 SER A O   1 
ATOM   434  C CB  . SER A 1 55  ? -27.66186 7.90538   -17.08823 1.000 26.87809 ?  110 SER A CB  1 
ATOM   435  O OG  . SER A 1 55  ? -26.85376 8.06362   -15.93310 1.000 32.01035 ?  110 SER A OG  1 
ATOM   436  N N   . GLN A 1 56  ? -24.49880 8.74161   -18.18392 1.000 23.70289 ?  111 GLN A N   1 
ATOM   437  C CA  . GLN A 1 56  ? -23.57787 9.86925   -18.07272 1.000 26.39837 ?  111 GLN A CA  1 
ATOM   438  C C   . GLN A 1 56  ? -23.07693 10.39514  -19.41409 1.000 26.59890 ?  111 GLN A C   1 
ATOM   439  O O   . GLN A 1 56  ? -22.41160 11.43001  -19.44494 1.000 27.83320 ?  111 GLN A O   1 
ATOM   440  C CB  . GLN A 1 56  ? -22.37882 9.48810   -17.19983 1.000 29.10249 ?  111 GLN A CB  1 
ATOM   441  C CG  . GLN A 1 56  ? -22.77443 9.11514   -15.79430 1.000 30.86917 ?  111 GLN A CG  1 
ATOM   442  C CD  . GLN A 1 56  ? -21.61828 8.60269   -14.98801 1.000 30.85598 ?  111 GLN A CD  1 
ATOM   443  O OE1 . GLN A 1 56  ? -20.53012 9.16355   -15.03453 1.000 36.17005 ?  111 GLN A OE1 1 
ATOM   444  N NE2 . GLN A 1 56  ? -21.84600 7.52824   -14.22692 1.000 30.72218 ?  111 GLN A NE2 1 
ATOM   445  N N   . LEU A 1 57  ? -23.36018 9.71970   -20.51916 1.000 24.52704 ?  112 LEU A N   1 
ATOM   446  C CA  . LEU A 1 57  ? -22.83271 10.14921  -21.80280 1.000 25.24976 ?  112 LEU A CA  1 
ATOM   447  C C   . LEU A 1 57  ? -23.74029 9.64103   -22.90053 1.000 30.75159 ?  112 LEU A C   1 
ATOM   448  O O   . LEU A 1 57  ? -24.12055 8.46790   -22.90178 1.000 27.72944 ?  112 LEU A O   1 
ATOM   449  C CB  . LEU A 1 57  ? -21.41012 9.62033   -22.04623 1.000 25.09816 ?  112 LEU A CB  1 
ATOM   450  C CG  . LEU A 1 57  ? -20.66397 10.07396  -23.30565 1.000 29.31441 ?  112 LEU A CG  1 
ATOM   451  C CD1 . LEU A 1 57  ? -20.41016 11.55933  -23.23491 1.000 30.35243 ?  112 LEU A CD1 1 
ATOM   452  C CD2 . LEU A 1 57  ? -19.33505 9.32169   -23.44227 1.000 27.59457 ?  112 LEU A CD2 1 
ATOM   453  N N   . HIS A 1 58  ? -24.03690 10.50652  -23.85686 1.000 27.28117 ?  113 HIS A N   1 
ATOM   454  C CA  . HIS A 1 58  ? -24.67368 10.06875  -25.09065 1.000 34.27843 ?  113 HIS A CA  1 
ATOM   455  C C   . HIS A 1 58  ? -23.85449 10.60874  -26.24836 1.000 28.44154 ?  113 HIS A C   1 
ATOM   456  O O   . HIS A 1 58  ? -23.48461 11.78151  -26.24722 1.000 32.72014 ?  113 HIS A O   1 
ATOM   457  C CB  . HIS A 1 58  ? -26.12998 10.52423  -25.13857 1.000 36.64769 ?  113 HIS A CB  1 
ATOM   458  C CG  . HIS A 1 58  ? -26.92770 10.06259  -23.95328 1.000 42.08718 ?  113 HIS A CG  1 
ATOM   459  N ND1 . HIS A 1 58  ? -27.41619 8.77779   -23.84092 1.000 45.49871 ?  113 HIS A ND1 1 
ATOM   460  C CD2 . HIS A 1 58  ? -27.29522 10.70416  -22.81652 1.000 42.09140 ?  113 HIS A CD2 1 
ATOM   461  C CE1 . HIS A 1 58  ? -28.05973 8.65073   -22.69241 1.000 42.69192 ?  113 HIS A CE1 1 
ATOM   462  N NE2 . HIS A 1 58  ? -28.00210 9.80431   -22.05327 1.000 39.13762 ?  113 HIS A NE2 1 
ATOM   463  N N   . ILE A 1 59  ? -23.50196 9.74459   -27.18326 1.000 29.40005 ?  114 ILE A N   1 
ATOM   464  C CA  . ILE A 1 59  ? -22.55049 10.10332  -28.22883 1.000 33.11625 ?  114 ILE A CA  1 
ATOM   465  C C   . ILE A 1 59  ? -23.29559 10.75545  -29.38247 1.000 32.26901 ?  114 ILE A C   1 
ATOM   466  O O   . ILE A 1 59  ? -24.32313 10.24712  -29.84214 1.000 35.20184 ?  114 ILE A O   1 
ATOM   467  C CB  . ILE A 1 59  ? -21.75679 8.87880   -28.71625 1.000 30.31177 ?  114 ILE A CB  1 
ATOM   468  C CG1 . ILE A 1 59  ? -21.22234 8.07880   -27.53566 1.000 33.80117 ?  114 ILE A CG1 1 
ATOM   469  C CG2 . ILE A 1 59  ? -20.55195 9.33028   -29.56302 1.000 28.54409 ?  114 ILE A CG2 1 
ATOM   470  C CD1 . ILE A 1 59  ? -19.99225 8.67025   -26.91936 1.000 28.63534 ?  114 ILE A CD1 1 
ATOM   471  N N   . THR A 1 60  ? -22.78159 11.89072  -29.84045 1.000 31.68191 ?  115 THR A N   1 
ATOM   472  C CA  . THR A 1 60  ? -23.26346 12.52107  -31.05886 1.000 28.90572 ?  115 THR A CA  1 
ATOM   473  C C   . THR A 1 60  ? -22.05777 12.67039  -31.97540 1.000 32.08629 ?  115 THR A C   1 
ATOM   474  O O   . THR A 1 60  ? -20.91916 12.49490  -31.51765 1.000 28.62524 ?  115 THR A O   1 
ATOM   475  C CB  . THR A 1 60  ? -23.90743 13.87547  -30.75306 1.000 35.21308 ?  115 THR A CB  1 
ATOM   476  O OG1 . THR A 1 60  ? -22.89587 14.88637  -30.78553 1.000 34.46455 ?  115 THR A OG1 1 
ATOM   477  C CG2 . THR A 1 60  ? -24.56088 13.86967  -29.38890 1.000 34.54403 ?  115 THR A CG2 1 
ATOM   478  N N   . PRO A 1 61  ? -22.24100 12.97603  -33.26326 1.000 30.53431 ?  116 PRO A N   1 
ATOM   479  C CA  . PRO A 1 61  ? -21.07172 13.17218  -34.13329 1.000 29.42130 ?  116 PRO A CA  1 
ATOM   480  C C   . PRO A 1 61  ? -20.17490 14.30796  -33.67591 1.000 29.15256 ?  116 PRO A C   1 
ATOM   481  O O   . PRO A 1 61  ? -19.08137 14.45780  -34.22077 1.000 34.35190 ?  116 PRO A O   1 
ATOM   482  C CB  . PRO A 1 61  ? -21.69256 13.46001  -35.51041 1.000 31.99465 ?  116 PRO A CB  1 
ATOM   483  C CG  . PRO A 1 61  ? -23.09038 12.90951  -35.42129 1.000 27.86867 ?  116 PRO A CG  1 
ATOM   484  C CD  . PRO A 1 61  ? -23.51221 13.07745  -34.00871 1.000 29.06538 ?  116 PRO A CD  1 
ATOM   485  N N   . GLY A 1 62  ? -20.58628 15.08443  -32.67724 1.000 26.08299 ?  117 GLY A N   1 
ATOM   486  C CA  . GLY A 1 62  ? -19.78564 16.17135  -32.16758 1.000 31.29883 ?  117 GLY A CA  1 
ATOM   487  C C   . GLY A 1 62  ? -19.07811 15.84432  -30.87138 1.000 33.34883 ?  117 GLY A C   1 
ATOM   488  O O   . GLY A 1 62  ? -18.25179 16.63478  -30.41148 1.000 31.49437 ?  117 GLY A O   1 
ATOM   489  N N   . THR A 1 63  ? -19.37462 14.68784  -30.27547 1.000 29.37570 ?  118 THR A N   1 
ATOM   490  C CA  . THR A 1 63  ? -18.68830 14.29621  -29.05057 1.000 28.11442 ?  118 THR A CA  1 
ATOM   491  C C   . THR A 1 63  ? -17.19677 14.06778  -29.30487 1.000 27.86992 ?  118 THR A C   1 
ATOM   492  O O   . THR A 1 63  ? -16.80813 13.34944  -30.23127 1.000 25.70842 ?  118 THR A O   1 
ATOM   493  C CB  . THR A 1 63  ? -19.30615 13.02237  -28.46936 1.000 28.59484 ?  118 THR A CB  1 
ATOM   494  O OG1 . THR A 1 63  ? -20.73051 13.05840  -28.61899 1.000 26.32543 ?  118 THR A OG1 1 
ATOM   495  C CG2 . THR A 1 63  ? -18.93797 12.88661  -27.01056 1.000 25.44077 ?  118 THR A CG2 1 
ATOM   496  N N   . ALA A 1 64  ? -16.36142 14.65778  -28.46484 1.000 25.21126 ?  119 ALA A N   1 
ATOM   497  C CA  . ALA A 1 64  ? -14.93509 14.41204  -28.58622 1.000 25.44244 ?  119 ALA A CA  1 
ATOM   498  C C   . ALA A 1 64  ? -14.53002 13.28537  -27.64592 1.000 26.46156 ?  119 ALA A C   1 
ATOM   499  O O   . ALA A 1 64  ? -15.19334 13.01232  -26.64234 1.000 26.67794 ?  119 ALA A O   1 
ATOM   500  C CB  . ALA A 1 64  ? -14.13729 15.68607  -28.27809 1.000 23.87767 ?  119 ALA A CB  1 
ATOM   501  N N   . TYR A 1 65  ? -13.42981 12.61822  -27.99492 1.000 25.67109 ?  120 TYR A N   1 
ATOM   502  C CA  . TYR A 1 65  ? -12.87200 11.57864  -27.13146 1.000 22.43630 ?  120 TYR A CA  1 
ATOM   503  C C   . TYR A 1 65  ? -12.72788 12.05315  -25.68908 1.000 24.31905 ?  120 TYR A C   1 
ATOM   504  O O   . TYR A 1 65  ? -13.03563 11.31223  -24.75010 1.000 21.25641 ?  120 TYR A O   1 
ATOM   505  C CB  . TYR A 1 65  ? -11.51148 11.12449  -27.66900 1.000 21.87465 ?  120 TYR A CB  1 
ATOM   506  C CG  . TYR A 1 65  ? -10.79490 10.18043  -26.71814 1.000 24.55256 ?  120 TYR A CG  1 
ATOM   507  C CD1 . TYR A 1 65  ? -11.25465 8.86366   -26.52557 1.000 23.84071 ?  120 TYR A CD1 1 
ATOM   508  C CD2 . TYR A 1 65  ? -9.69845  10.60837  -25.98392 1.000 24.35313 ?  120 TYR A CD2 1 
ATOM   509  C CE1 . TYR A 1 65  ? -10.60317 7.99168   -25.63386 1.000 20.71380 ?  120 TYR A CE1 1 
ATOM   510  C CE2 . TYR A 1 65  ? -9.04797  9.76410   -25.10749 1.000 24.99853 ?  120 TYR A CE2 1 
ATOM   511  C CZ  . TYR A 1 65  ? -9.49523  8.46352   -24.92745 1.000 25.12404 ?  120 TYR A CZ  1 
ATOM   512  O OH  . TYR A 1 65  ? -8.82434  7.65434   -24.04026 1.000 23.90069 ?  120 TYR A OH  1 
ATOM   513  N N   . GLN A 1 66  ? -12.27649 13.29471  -25.48273 1.000 22.20038 ?  121 GLN A N   1 
ATOM   514  C CA  . GLN A 1 66  ? -12.06018 13.74469  -24.10856 1.000 23.37759 ?  121 GLN A CA  1 
ATOM   515  C C   . GLN A 1 66  ? -13.33949 13.67021  -23.26332 1.000 25.69989 ?  121 GLN A C   1 
ATOM   516  O O   . GLN A 1 66  ? -13.25478 13.51179  -22.04311 1.000 23.76067 ?  121 GLN A O   1 
ATOM   517  C CB  . GLN A 1 66  ? -11.47476 15.15834  -24.09758 1.000 33.76921 ?  121 GLN A CB  1 
ATOM   518  C CG  . GLN A 1 66  ? -12.50199 16.26310  -23.95768 1.000 35.08694 ?  121 GLN A CG  1 
ATOM   519  C CD  . GLN A 1 66  ? -11.87224 17.65667  -23.91831 1.000 36.54611 ?  121 GLN A CD  1 
ATOM   520  O OE1 . GLN A 1 66  ? -10.75621 17.84236  -23.43137 1.000 39.70039 ?  121 GLN A OE1 1 
ATOM   521  N NE2 . GLN A 1 66  ? -12.58893 18.63466  -24.44906 1.000 37.37851 ?  121 GLN A NE2 1 
ATOM   522  N N   . SER A 1 67  ? -14.53217 13.74366  -23.87404 1.000 27.25601 ?  122 SER A N   1 
ATOM   523  C CA  . SER A 1 67  ? -15.74620 13.59983  -23.06263 1.000 25.57145 ?  122 SER A CA  1 
ATOM   524  C C   . SER A 1 67  ? -15.93100 12.15999  -22.58125 1.000 26.68996 ?  122 SER A C   1 
ATOM   525  O O   . SER A 1 67  ? -16.35279 11.93110  -21.44047 1.000 25.38230 ?  122 SER A O   1 
ATOM   526  C CB  . SER A 1 67  ? -16.98494 14.06094  -23.83595 1.000 29.76162 ?  122 SER A CB  1 
ATOM   527  O OG  . SER A 1 67  ? -16.98260 15.46783  -23.99006 1.000 29.69436 ?  122 SER A OG  1 
ATOM   528  N N   . PHE A 1 68  ? -15.66519 11.18707  -23.45706 1.000 23.72567 ?  123 PHE A N   1 
ATOM   529  C CA  . PHE A 1 68  ? -15.67471 9.77241   -23.08453 1.000 26.19368 ?  123 PHE A CA  1 
ATOM   530  C C   . PHE A 1 68  ? -14.59370 9.47843   -22.04098 1.000 23.83410 ?  123 PHE A C   1 
ATOM   531  O O   . PHE A 1 68  ? -14.85195 8.83028   -21.02207 1.000 21.52779 ?  123 PHE A O   1 
ATOM   532  C CB  . PHE A 1 68  ? -15.48772 8.94487   -24.36139 1.000 23.79162 ?  123 PHE A CB  1 
ATOM   533  C CG  . PHE A 1 68  ? -15.27800 7.45819   -24.14438 1.000 23.01400 ?  123 PHE A CG  1 
ATOM   534  C CD1 . PHE A 1 68  ? -16.36209 6.60073   -24.00401 1.000 22.92042 ?  123 PHE A CD1 1 
ATOM   535  C CD2 . PHE A 1 68  ? -13.99776 6.91916   -24.15421 1.000 20.81863 ?  123 PHE A CD2 1 
ATOM   536  C CE1 . PHE A 1 68  ? -16.16235 5.23696   -23.83430 1.000 21.88031 ?  123 PHE A CE1 1 
ATOM   537  C CE2 . PHE A 1 68  ? -13.77359 5.56430   -23.97689 1.000 23.62586 ?  123 PHE A CE2 1 
ATOM   538  C CZ  . PHE A 1 68  ? -14.84296 4.71028   -23.82149 1.000 23.31492 ?  123 PHE A CZ  1 
ATOM   539  N N   . GLU A 1 69  ? -13.39292 10.01333  -22.24937 1.000 19.94771 ?  124 GLU A N   1 
ATOM   540  C CA  . GLU A 1 69  ? -12.30014 9.79820   -21.30589 1.000 25.40770 ?  124 GLU A CA  1 
ATOM   541  C C   . GLU A 1 69  ? -12.64559 10.30614  -19.90769 1.000 23.12818 ?  124 GLU A C   1 
ATOM   542  O O   . GLU A 1 69  ? -12.29817 9.66408   -18.91588 1.000 23.52237 ?  124 GLU A O   1 
ATOM   543  C CB  . GLU A 1 69  ? -11.01490 10.46059  -21.82879 1.000 24.97890 ?  124 GLU A CB  1 
ATOM   544  C CG  . GLU A 1 69  ? -9.80328  10.27408  -20.91632 1.000 26.06850 ?  124 GLU A CG  1 
ATOM   545  C CD  . GLU A 1 69  ? -8.53559  10.96339  -21.44939 1.000 36.35026 ?  124 GLU A CD  1 
ATOM   546  O OE1 . GLU A 1 69  ? -8.64944  11.94787  -22.22042 1.000 33.18046 ?  124 GLU A OE1 1 
ATOM   547  O OE2 . GLU A 1 69  ? -7.41980  10.50591  -21.10634 1.000 38.15678 -1 124 GLU A OE2 1 
ATOM   548  N N   . GLN A 1 70  ? -13.33272 11.45035  -19.79892 1.000 20.26978 ?  125 GLN A N   1 
ATOM   549  C CA  . GLN A 1 70  ? -13.67056 11.97850  -18.47495 1.000 23.29472 ?  125 GLN A CA  1 
ATOM   550  C C   . GLN A 1 70  ? -14.67028 11.08557  -17.74177 1.000 21.38145 ?  125 GLN A C   1 
ATOM   551  O O   . GLN A 1 70  ? -14.55892 10.87810  -16.52824 1.000 22.49618 ?  125 GLN A O   1 
ATOM   552  C CB  . GLN A 1 70  ? -14.24859 13.39166  -18.59685 1.000 26.16218 ?  125 GLN A CB  1 
ATOM   553  C CG  . GLN A 1 70  ? -13.24031 14.45971  -18.95529 1.000 32.58347 ?  125 GLN A CG  1 
ATOM   554  C CD  . GLN A 1 70  ? -13.91831 15.76517  -19.34442 1.000 40.82526 ?  125 GLN A CD  1 
ATOM   555  O OE1 . GLN A 1 70  ? -14.99210 15.76659  -19.96666 1.000 39.88393 ?  125 GLN A OE1 1 
ATOM   556  N NE2 . GLN A 1 70  ? -13.31366 16.88361  -18.95606 1.000 44.26750 ?  125 GLN A NE2 1 
ATOM   557  N N   . VAL A 1 71  ? -15.68009 10.59121  -18.44772 1.000 20.72091 ?  126 VAL A N   1 
ATOM   558  C CA  . VAL A 1 71  ? -16.65309 9.69560   -17.82229 1.000 22.27221 ?  126 VAL A CA  1 
ATOM   559  C C   . VAL A 1 71  ? -15.98003 8.40103   -17.38949 1.000 21.84238 ?  126 VAL A C   1 
ATOM   560  O O   . VAL A 1 71  ? -16.22970 7.88814   -16.29167 1.000 21.64576 ?  126 VAL A O   1 
ATOM   561  C CB  . VAL A 1 71  ? -17.82402 9.45654   -18.79631 1.000 22.73147 ?  126 VAL A CB  1 
ATOM   562  C CG1 . VAL A 1 71  ? -18.78234 8.38134   -18.27795 1.000 25.37090 ?  126 VAL A CG1 1 
ATOM   563  C CG2 . VAL A 1 71  ? -18.57980 10.77613  -19.03143 1.000 26.18000 ?  126 VAL A CG2 1 
ATOM   564  N N   . VAL A 1 72  ? -15.11480 7.84548   -18.23914 1.000 19.82406 ?  127 VAL A N   1 
ATOM   565  C CA  . VAL A 1 72  ? -14.47978 6.58539   -17.86926 1.000 22.34284 ?  127 VAL A CA  1 
ATOM   566  C C   . VAL A 1 72  ? -13.49488 6.81146   -16.73062 1.000 21.09961 ?  127 VAL A C   1 
ATOM   567  O O   . VAL A 1 72  ? -13.38323 5.98719   -15.81519 1.000 20.05967 ?  127 VAL A O   1 
ATOM   568  C CB  . VAL A 1 72  ? -13.82166 5.93480   -19.10177 1.000 22.04507 ?  127 VAL A CB  1 
ATOM   569  C CG1 . VAL A 1 72  ? -13.02880 4.74477   -18.69637 1.000 19.41515 ?  127 VAL A CG1 1 
ATOM   570  C CG2 . VAL A 1 72  ? -14.92687 5.50555   -20.10910 1.000 17.64995 ?  127 VAL A CG2 1 
ATOM   571  N N   . ASN A 1 73  ? -12.79520 7.94925   -16.74664 1.000 19.82459 ?  128 ASN A N   1 
ATOM   572  C CA  . ASN A 1 73  ? -11.91463 8.30371   -15.63388 1.000 25.33104 ?  128 ASN A CA  1 
ATOM   573  C C   . ASN A 1 73  ? -12.66038 8.31241   -14.30501 1.000 23.74271 ?  128 ASN A C   1 
ATOM   574  O O   . ASN A 1 73  ? -12.08517 7.95917   -13.26903 1.000 21.24083 ?  128 ASN A O   1 
ATOM   575  C CB  . ASN A 1 73  ? -11.28212 9.67882   -15.86392 1.000 23.41109 ?  128 ASN A CB  1 
ATOM   576  C CG  . ASN A 1 73  ? -10.08853 9.62998   -16.77867 1.000 24.87586 ?  128 ASN A CG  1 
ATOM   577  O OD1 . ASN A 1 73  ? -9.60351  8.55588   -17.14038 1.000 21.41080 ?  128 ASN A OD1 1 
ATOM   578  N ND2 . ASN A 1 73  ? -9.58222  10.81186  -17.14437 1.000 28.04468 ?  128 ASN A ND2 1 
ATOM   579  N N   . GLU A 1 74  ? -13.92948 8.72660   -14.31503 1.000 24.34879 ?  129 GLU A N   1 
ATOM   580  C CA  . GLU A 1 74  ? -14.73802 8.72077   -13.09775 1.000 25.42646 ?  129 GLU A CA  1 
ATOM   581  C C   . GLU A 1 74  ? -15.09432 7.29594   -12.68383 1.000 24.52742 ?  129 GLU A C   1 
ATOM   582  O O   . GLU A 1 74  ? -15.11430 6.97236   -11.49178 1.000 22.78617 ?  129 GLU A O   1 
ATOM   583  C CB  . GLU A 1 74  ? -15.99224 9.57528   -13.31234 1.000 26.80752 ?  129 GLU A CB  1 
ATOM   584  C CG  . GLU A 1 74  ? -16.96397 9.59858   -12.13016 1.000 37.73548 ?  129 GLU A CG  1 
ATOM   585  C CD  . GLU A 1 74  ? -16.46069 10.43149  -10.94630 1.000 46.95489 ?  129 GLU A CD  1 
ATOM   586  O OE1 . GLU A 1 74  ? -17.05997 10.33048  -9.84477  1.000 50.79976 ?  129 GLU A OE1 1 
ATOM   587  O OE2 . GLU A 1 74  ? -15.47268 11.18478  -11.11514 1.000 50.04260 -1 129 GLU A OE2 1 
ATOM   588  N N   . LEU A 1 75  ? -15.33473 6.41992   -13.66013 1.000 22.74081 ?  130 LEU A N   1 
ATOM   589  C CA  . LEU A 1 75  ? -15.56399 5.01158   -13.36622 1.000 24.36130 ?  130 LEU A CA  1 
ATOM   590  C C   . LEU A 1 75  ? -14.39040 4.39726   -12.60678 1.000 23.92161 ?  130 LEU A C   1 
ATOM   591  O O   . LEU A 1 75  ? -14.58995 3.64728   -11.64888 1.000 25.41807 ?  130 LEU A O   1 
ATOM   592  C CB  . LEU A 1 75  ? -15.81714 4.25740   -14.66683 1.000 19.23173 ?  130 LEU A CB  1 
ATOM   593  C CG  . LEU A 1 75  ? -15.75811 2.73131   -14.62190 1.000 20.66974 ?  130 LEU A CG  1 
ATOM   594  C CD1 . LEU A 1 75  ? -16.78032 2.13776   -13.60992 1.000 23.54858 ?  130 LEU A CD1 1 
ATOM   595  C CD2 . LEU A 1 75  ? -16.04216 2.20652   -16.03302 1.000 19.68677 ?  130 LEU A CD2 1 
ATOM   596  N N   . PHE A 1 76  ? -13.15926 4.69896   -13.01777 1.000 23.60439 ?  131 PHE A N   1 
ATOM   597  C CA  . PHE A 1 76  ? -11.96154 4.16888   -12.37856 1.000 22.53574 ?  131 PHE A CA  1 
ATOM   598  C C   . PHE A 1 76  ? -11.40797 5.08130   -11.28931 1.000 28.19800 ?  131 PHE A C   1 
ATOM   599  O O   . PHE A 1 76  ? -10.27500 4.86449   -10.83598 1.000 26.73460 ?  131 PHE A O   1 
ATOM   600  C CB  . PHE A 1 76  ? -10.88356 3.89503   -13.43276 1.000 21.61446 ?  131 PHE A CB  1 
ATOM   601  C CG  . PHE A 1 76  ? -11.26428 2.81559   -14.41812 1.000 21.02597 ?  131 PHE A CG  1 
ATOM   602  C CD1 . PHE A 1 76  ? -11.37293 1.48821   -14.01353 1.000 21.81742 ?  131 PHE A CD1 1 
ATOM   603  C CD2 . PHE A 1 76  ? -11.50433 3.12930   -15.74157 1.000 19.21796 ?  131 PHE A CD2 1 
ATOM   604  C CE1 . PHE A 1 76  ? -11.71501 0.49317   -14.93105 1.000 17.53813 ?  131 PHE A CE1 1 
ATOM   605  C CE2 . PHE A 1 76  ? -11.85287 2.15363   -16.66022 1.000 18.93821 ?  131 PHE A CE2 1 
ATOM   606  C CZ  . PHE A 1 76  ? -11.94642 0.82510   -16.25787 1.000 19.63629 ?  131 PHE A CZ  1 
ATOM   607  N N   . ARG A 1 77  ? -12.19918 6.06464   -10.84097 1.000 29.44297 ?  132 ARG A N   1 
ATOM   608  C CA  . ARG A 1 77  ? -11.72499 7.07349   -9.89039  1.000 33.59379 ?  132 ARG A CA  1 
ATOM   609  C C   . ARG A 1 77  ? -11.06773 6.43325   -8.67246  1.000 31.44435 ?  132 ARG A C   1 
ATOM   610  O O   . ARG A 1 77  ? -9.99292  6.86252   -8.24207  1.000 36.40318 ?  132 ARG A O   1 
ATOM   611  C CB  . ARG A 1 77  ? -12.90453 7.97245   -9.47527  1.000 36.82806 ?  132 ARG A CB  1 
ATOM   612  C CG  . ARG A 1 77  ? -12.58046 9.16622   -8.56442  1.000 41.72036 ?  132 ARG A CG  1 
ATOM   613  C CD  . ARG A 1 77  ? -11.88080 10.29886  -9.33082  1.000 41.16349 ?  132 ARG A CD  1 
ATOM   614  N NE  . ARG A 1 77  ? -12.73720 10.93078  -10.34272 1.000 39.56448 ?  132 ARG A NE  1 
ATOM   615  C CZ  . ARG A 1 77  ? -12.28395 11.56166  -11.42948 1.000 41.69499 ?  132 ARG A CZ  1 
ATOM   616  N NH1 . ARG A 1 77  ? -10.97919 11.64895  -11.65906 1.000 38.86823 ?  132 ARG A NH1 1 
ATOM   617  N NH2 . ARG A 1 77  ? -13.13494 12.10852  -12.29097 1.000 37.64914 ?  132 ARG A NH2 1 
ATOM   618  N N   . ASP A 1 78  ? -11.66931 5.37214   -8.13587  1.000 32.71208 ?  133 ASP A N   1 
ATOM   619  C CA  . ASP A 1 78  ? -11.18167 4.70580   -6.93227  1.000 35.39694 ?  133 ASP A CA  1 
ATOM   620  C C   . ASP A 1 78  ? -10.32493 3.47434   -7.22132  1.000 32.45059 ?  133 ASP A C   1 
ATOM   621  O O   . ASP A 1 78  ? -10.21706 2.59195   -6.36228  1.000 34.75433 ?  133 ASP A O   1 
ATOM   622  C CB  . ASP A 1 78  ? -12.35690 4.30260   -6.04774  1.000 32.96385 ?  133 ASP A CB  1 
ATOM   623  C CG  . ASP A 1 78  ? -13.16604 5.48808   -5.60231  1.000 41.48671 ?  133 ASP A CG  1 
ATOM   624  O OD1 . ASP A 1 78  ? -12.54337 6.48707   -5.19236  1.000 42.32592 ?  133 ASP A OD1 1 
ATOM   625  O OD2 . ASP A 1 78  ? -14.41573 5.42688   -5.65887  1.000 44.43919 -1 133 ASP A OD2 1 
ATOM   626  N N   . GLY A 1 79  ? -9.74663  3.37764   -8.39979  1.000 29.13363 ?  134 GLY A N   1 
ATOM   627  C CA  . GLY A 1 79  ? -8.86385  2.26519   -8.67304  1.000 27.22566 ?  134 GLY A CA  1 
ATOM   628  C C   . GLY A 1 79  ? -9.41815  1.37508   -9.76825  1.000 27.47650 ?  134 GLY A C   1 
ATOM   629  O O   . GLY A 1 79  ? -10.62959 1.31205   -10.00537 1.000 26.01666 ?  134 GLY A O   1 
ATOM   630  N N   . VAL A 1 80  ? -8.52932  0.68787   -10.45022 1.000 23.68210 ?  135 VAL A N   1 
ATOM   631  C CA  . VAL A 1 80  ? -8.91744  -0.25636  -11.48535 1.000 23.07224 ?  135 VAL A CA  1 
ATOM   632  C C   . VAL A 1 80  ? -9.16744  -1.61178  -10.83844 1.000 23.43698 ?  135 VAL A C   1 
ATOM   633  O O   . VAL A 1 80  ? -8.47519  -1.99744  -9.90391  1.000 22.82120 ?  135 VAL A O   1 
ATOM   634  C CB  . VAL A 1 80  ? -7.82629  -0.32279  -12.56397 1.000 23.38386 ?  135 VAL A CB  1 
ATOM   635  C CG1 . VAL A 1 80  ? -8.16352  -1.36373  -13.64058 1.000 21.97859 ?  135 VAL A CG1 1 
ATOM   636  C CG2 . VAL A 1 80  ? -7.63067  1.06768   -13.14918 1.000 21.89140 ?  135 VAL A CG2 1 
ATOM   637  N N   . ASN A 1 81  ? -10.20620 -2.30947  -11.27878 1.000 24.26910 ?  136 ASN A N   1 
ATOM   638  C CA  . ASN A 1 81  ? -10.35088 -3.72164  -10.95202 1.000 18.28855 ?  136 ASN A CA  1 
ATOM   639  C C   . ASN A 1 81  ? -11.05336 -4.36044  -12.13124 1.000 19.69232 ?  136 ASN A C   1 
ATOM   640  O O   . ASN A 1 81  ? -11.54615 -3.66802  -13.01800 1.000 17.95754 ?  136 ASN A O   1 
ATOM   641  C CB  . ASN A 1 81  ? -11.10272 -3.95413  -9.62185  1.000 22.08746 ?  136 ASN A CB  1 
ATOM   642  C CG  . ASN A 1 81  ? -12.58638 -3.49829  -9.66213  1.000 24.25554 ?  136 ASN A CG  1 
ATOM   643  O OD1 . ASN A 1 81  ? -13.38911 -3.95187  -10.49601 1.000 21.06933 ?  136 ASN A OD1 1 
ATOM   644  N ND2 . ASN A 1 81  ? -12.95434 -2.63576  -8.71842  1.000 24.73665 ?  136 ASN A ND2 1 
ATOM   645  N N   . TRP A 1 82  ? -11.07627 -5.69775  -12.14734 1.000 18.53353 ?  137 TRP A N   1 
ATOM   646  C CA  . TRP A 1 82  ? -11.62207 -6.40169  -13.29859 1.000 19.35040 ?  137 TRP A CA  1 
ATOM   647  C C   . TRP A 1 82  ? -13.10645 -6.10387  -13.47985 1.000 16.77038 ?  137 TRP A C   1 
ATOM   648  O O   . TRP A 1 82  ? -13.59764 -6.05993  -14.61390 1.000 18.02839 ?  137 TRP A O   1 
ATOM   649  C CB  . TRP A 1 82  ? -11.40631 -7.90481  -13.15191 1.000 20.17726 ?  137 TRP A CB  1 
ATOM   650  C CG  . TRP A 1 82  ? -9.97709  -8.31233  -13.33637 1.000 23.95803 ?  137 TRP A CG  1 
ATOM   651  C CD1 . TRP A 1 82  ? -9.15196  -8.84993  -12.39034 1.000 23.15889 ?  137 TRP A CD1 1 
ATOM   652  C CD2 . TRP A 1 82  ? -9.20417  -8.21114  -14.53751 1.000 20.98543 ?  137 TRP A CD2 1 
ATOM   653  N NE1 . TRP A 1 82  ? -7.91731  -9.08915  -12.92600 1.000 20.51578 ?  137 TRP A NE1 1 
ATOM   654  C CE2 . TRP A 1 82  ? -7.91826  -8.71512  -14.24423 1.000 27.31474 ?  137 TRP A CE2 1 
ATOM   655  C CE3 . TRP A 1 82  ? -9.47352  -7.74797  -15.83544 1.000 23.10567 ?  137 TRP A CE3 1 
ATOM   656  C CZ2 . TRP A 1 82  ? -6.89563  -8.76486  -15.19526 1.000 21.99783 ?  137 TRP A CZ2 1 
ATOM   657  C CZ3 . TRP A 1 82  ? -8.45434  -7.80648  -16.78592 1.000 24.97049 ?  137 TRP A CZ3 1 
ATOM   658  C CH2 . TRP A 1 82  ? -7.18655  -8.31731  -16.45723 1.000 22.04325 ?  137 TRP A CH2 1 
ATOM   659  N N   . GLY A 1 83  ? -13.83834 -5.92206  -12.37926 1.000 17.07861 ?  138 GLY A N   1 
ATOM   660  C CA  . GLY A 1 83  ? -15.25638 -5.58652  -12.49653 1.000 21.79830 ?  138 GLY A CA  1 
ATOM   661  C C   . GLY A 1 83  ? -15.48939 -4.25029  -13.17891 1.000 19.32482 ?  138 GLY A C   1 
ATOM   662  O O   . GLY A 1 83  ? -16.35673 -4.12765  -14.04233 1.000 18.73462 ?  138 GLY A O   1 
ATOM   663  N N   . ARG A 1 84  ? -14.71262 -3.23029  -12.80274 1.000 19.34887 ?  139 ARG A N   1 
ATOM   664  C CA  . ARG A 1 84  ? -14.83792 -1.93601  -13.46315 1.000 18.95042 ?  139 ARG A CA  1 
ATOM   665  C C   . ARG A 1 84  ? -14.46774 -2.02881  -14.92980 1.000 17.80765 ?  139 ARG A C   1 
ATOM   666  O O   . ARG A 1 84  ? -15.02425 -1.30907  -15.76600 1.000 17.69884 ?  139 ARG A O   1 
ATOM   667  C CB  . ARG A 1 84  ? -13.97334 -0.90299  -12.73085 1.000 18.61427 ?  139 ARG A CB  1 
ATOM   668  C CG  . ARG A 1 84  ? -14.69155 -0.40969  -11.48519 1.000 21.61392 ?  139 ARG A CG  1 
ATOM   669  C CD  . ARG A 1 84  ? -13.79685 0.34010   -10.50627 1.000 24.70469 ?  139 ARG A CD  1 
ATOM   670  N NE  . ARG A 1 84  ? -14.53074 0.55207   -9.26163  1.000 28.11203 ?  139 ARG A NE  1 
ATOM   671  C CZ  . ARG A 1 84  ? -13.97548 0.67264   -8.05850  1.000 29.99293 ?  139 ARG A CZ  1 
ATOM   672  N NH1 . ARG A 1 84  ? -12.65261 0.64691   -7.91675  1.000 29.38051 ?  139 ARG A NH1 1 
ATOM   673  N NH2 . ARG A 1 84  ? -14.75935 0.83868   -6.99708  1.000 27.66434 ?  139 ARG A NH2 1 
ATOM   674  N N   . ILE A 1 85  ? -13.53791 -2.92020  -15.26077 1.000 17.03649 ?  140 ILE A N   1 
ATOM   675  C CA  . ILE A 1 85  ? -13.18716 -3.13617  -16.65089 1.000 15.57718 ?  140 ILE A CA  1 
ATOM   676  C C   . ILE A 1 85  ? -14.34738 -3.77154  -17.41183 1.000 14.63352 ?  140 ILE A C   1 
ATOM   677  O O   . ILE A 1 85  ? -14.63284 -3.39574  -18.54902 1.000 17.73604 ?  140 ILE A O   1 
ATOM   678  C CB  . ILE A 1 85  ? -11.90218 -3.97686  -16.71259 1.000 19.36978 ?  140 ILE A CB  1 
ATOM   679  C CG1 . ILE A 1 85  ? -10.71837 -3.14804  -16.16600 1.000 17.00705 ?  140 ILE A CG1 1 
ATOM   680  C CG2 . ILE A 1 85  ? -11.67238 -4.46997  -18.11384 1.000 18.67398 ?  140 ILE A CG2 1 
ATOM   681  C CD1 . ILE A 1 85  ? -9.39195  -3.86890  -16.24946 1.000 21.36357 ?  140 ILE A CD1 1 
ATOM   682  N N   . VAL A 1 86  ? -15.03006 -4.74978  -16.81132 1.000 16.92903 ?  141 VAL A N   1 
ATOM   683  C CA  . VAL A 1 86  ? -16.29211 -5.25208  -17.38330 1.000 16.91497 ?  141 VAL A CA  1 
ATOM   684  C C   . VAL A 1 86  ? -17.30494 -4.10971  -17.60723 1.000 16.47105 ?  141 VAL A C   1 
ATOM   685  O O   . VAL A 1 86  ? -17.88370 -3.97343  -18.68274 1.000 16.22412 ?  141 VAL A O   1 
ATOM   686  C CB  . VAL A 1 86  ? -16.86738 -6.35924  -16.48162 1.000 18.36879 ?  141 VAL A CB  1 
ATOM   687  C CG1 . VAL A 1 86  ? -18.23343 -6.79110  -16.96200 1.000 16.06834 ?  141 VAL A CG1 1 
ATOM   688  C CG2 . VAL A 1 86  ? -15.89057 -7.55584  -16.45948 1.000 16.36506 ?  141 VAL A CG2 1 
ATOM   689  N N   . ALA A 1 87  ? -17.52157 -3.26721  -16.60301 1.000 14.52999 ?  142 ALA A N   1 
ATOM   690  C CA  . ALA A 1 87  ? -18.45406 -2.14990  -16.78322 1.000 16.15147 ?  142 ALA A CA  1 
ATOM   691  C C   . ALA A 1 87  ? -18.04113 -1.25646  -17.94860 1.000 16.53990 ?  142 ALA A C   1 
ATOM   692  O O   . ALA A 1 87  ? -18.88637 -0.80256  -18.72689 1.000 16.89507 ?  142 ALA A O   1 
ATOM   693  C CB  . ALA A 1 87  ? -18.53754 -1.33970  -15.49353 1.000 18.50122 ?  142 ALA A CB  1 
ATOM   694  N N   . PHE A 1 88  ? -16.73260 -1.03354  -18.10912 1.000 18.14572 ?  143 PHE A N   1 
ATOM   695  C CA  . PHE A 1 88  ? -16.21781 -0.22040  -19.20074 1.000 16.98638 ?  143 PHE A CA  1 
ATOM   696  C C   . PHE A 1 88  ? -16.58036 -0.81448  -20.55649 1.000 16.54112 ?  143 PHE A C   1 
ATOM   697  O O   . PHE A 1 88  ? -16.95496 -0.07855  -21.47497 1.000 18.18848 ?  143 PHE A O   1 
ATOM   698  C CB  . PHE A 1 88  ? -14.69682 -0.08326  -19.01115 1.000 20.35971 ?  143 PHE A CB  1 
ATOM   699  C CG  . PHE A 1 88  ? -13.93636 0.29709   -20.23380 1.000 18.56593 ?  143 PHE A CG  1 
ATOM   700  C CD1 . PHE A 1 88  ? -13.75923 1.64001   -20.57577 1.000 21.20454 ?  143 PHE A CD1 1 
ATOM   701  C CD2 . PHE A 1 88  ? -13.32790 -0.67583  -21.01676 1.000 19.11987 ?  143 PHE A CD2 1 
ATOM   702  C CE1 . PHE A 1 88  ? -13.00370 1.99648   -21.69733 1.000 21.85835 ?  143 PHE A CE1 1 
ATOM   703  C CE2 . PHE A 1 88  ? -12.58015 -0.32369  -22.12924 1.000 20.91162 ?  143 PHE A CE2 1 
ATOM   704  C CZ  . PHE A 1 88  ? -12.42318 1.01554   -22.46898 1.000 18.04379 ?  143 PHE A CZ  1 
ATOM   705  N N   . PHE A 1 89  ? -16.46294 -2.13803  -20.71132 1.000 14.76812 ?  144 PHE A N   1 
ATOM   706  C CA  . PHE A 1 89  ? -16.87299 -2.77526  -21.96020 1.000 14.86251 ?  144 PHE A CA  1 
ATOM   707  C C   . PHE A 1 89  ? -18.38714 -2.67333  -22.15502 1.000 14.89289 ?  144 PHE A C   1 
ATOM   708  O O   . PHE A 1 89  ? -18.85519 -2.39078  -23.25565 1.000 16.82778 ?  144 PHE A O   1 
ATOM   709  C CB  . PHE A 1 89  ? -16.43727 -4.24201  -21.99213 1.000 12.99173 ?  144 PHE A CB  1 
ATOM   710  C CG  . PHE A 1 89  ? -14.99928 -4.44037  -22.46219 1.000 16.37274 ?  144 PHE A CG  1 
ATOM   711  C CD1 . PHE A 1 89  ? -13.95505 -4.43057  -21.54903 1.000 16.80354 ?  144 PHE A CD1 1 
ATOM   712  C CD2 . PHE A 1 89  ? -14.70811 -4.61533  -23.79986 1.000 16.69926 ?  144 PHE A CD2 1 
ATOM   713  C CE1 . PHE A 1 89  ? -12.61121 -4.58505  -21.96903 1.000 17.60504 ?  144 PHE A CE1 1 
ATOM   714  C CE2 . PHE A 1 89  ? -13.37648 -4.79719  -24.22960 1.000 19.62842 ?  144 PHE A CE2 1 
ATOM   715  C CZ  . PHE A 1 89  ? -12.33675 -4.77422  -23.30282 1.000 17.10087 ?  144 PHE A CZ  1 
ATOM   716  N N   . SER A 1 90  ? -19.16071 -2.89500  -21.09639 1.000 13.82436 ?  145 SER A N   1 
ATOM   717  C CA  . SER A 1 90  ? -20.61753 -2.77468  -21.21010 1.000 17.47479 ?  145 SER A CA  1 
ATOM   718  C C   . SER A 1 90  ? -21.04185 -1.34289  -21.53863 1.000 17.83302 ?  145 SER A C   1 
ATOM   719  O O   . SER A 1 90  ? -21.97131 -1.11589  -22.32533 1.000 16.63098 ?  145 SER A O   1 
ATOM   720  C CB  . SER A 1 90  ? -21.27324 -3.24161  -19.91408 1.000 16.41048 ?  145 SER A CB  1 
ATOM   721  O OG  . SER A 1 90  ? -21.09986 -4.64343  -19.74409 1.000 21.37396 ?  145 SER A OG  1 
ATOM   722  N N   . PHE A 1 91  ? -20.37670 -0.36668  -20.94019 1.000 17.82103 ?  146 PHE A N   1 
ATOM   723  C CA  . PHE A 1 91  ? -20.62853 1.03374   -21.27923 1.000 16.94572 ?  146 PHE A CA  1 
ATOM   724  C C   . PHE A 1 91  ? -20.43350 1.27529   -22.77657 1.000 19.65879 ?  146 PHE A C   1 
ATOM   725  O O   . PHE A 1 91  ? -21.31352 1.82701   -23.44974 1.000 17.45832 ?  146 PHE A O   1 
ATOM   726  C CB  . PHE A 1 91  ? -19.70561 1.89974   -20.41842 1.000 16.62246 ?  146 PHE A CB  1 
ATOM   727  C CG  . PHE A 1 91  ? -19.77808 3.38612   -20.68277 1.000 19.71789 ?  146 PHE A CG  1 
ATOM   728  C CD1 . PHE A 1 91  ? -20.98852 4.08656   -20.59099 1.000 18.78833 ?  146 PHE A CD1 1 
ATOM   729  C CD2 . PHE A 1 91  ? -18.61307 4.08999   -20.96965 1.000 18.64134 ?  146 PHE A CD2 1 
ATOM   730  C CE1 . PHE A 1 91  ? -21.03377 5.46959   -20.79826 1.000 21.45078 ?  146 PHE A CE1 1 
ATOM   731  C CE2 . PHE A 1 91  ? -18.64342 5.48478   -21.18202 1.000 24.59746 ?  146 PHE A CE2 1 
ATOM   732  C CZ  . PHE A 1 91  ? -19.85943 6.17315   -21.09150 1.000 21.16269 ?  146 PHE A CZ  1 
ATOM   733  N N   . GLY A 1 92  ? -19.29825 0.83355   -23.32992 1.000 16.87425 ?  147 GLY A N   1 
ATOM   734  C CA  . GLY A 1 92  ? -19.04891 1.07831   -24.74609 1.000 16.06088 ?  147 GLY A CA  1 
ATOM   735  C C   . GLY A 1 92  ? -20.05023 0.37911   -25.63498 1.000 18.74200 ?  147 GLY A C   1 
ATOM   736  O O   . GLY A 1 92  ? -20.45030 0.90363   -26.67778 1.000 16.84094 ?  147 GLY A O   1 
ATOM   737  N N   . GLY A 1 93  ? -20.46189 -0.83399  -25.25264 1.000 17.65157 ?  148 GLY A N   1 
ATOM   738  C CA  . GLY A 1 93  ? -21.47482 -1.52727  -26.01566 1.000 18.64762 ?  148 GLY A CA  1 
ATOM   739  C C   . GLY A 1 93  ? -22.82527 -0.81590  -25.99381 1.000 16.64516 ?  148 GLY A C   1 
ATOM   740  O O   . GLY A 1 93  ? -23.54000 -0.81331  -26.99539 1.000 18.19308 ?  148 GLY A O   1 
ATOM   741  N N   . ALA A 1 94  ? -23.18533 -0.21303  -24.85241 1.000 17.13530 ?  149 ALA A N   1 
ATOM   742  C CA  . ALA A 1 94  ? -24.43585 0.54472   -24.77660 1.000 22.57304 ?  149 ALA A CA  1 
ATOM   743  C C   . ALA A 1 94  ? -24.38603 1.78714   -25.65773 1.000 20.86038 ?  149 ALA A C   1 
ATOM   744  O O   . ALA A 1 94  ? -25.39123 2.14987   -26.27761 1.000 20.64059 ?  149 ALA A O   1 
ATOM   745  C CB  . ALA A 1 94  ? -24.73867 0.92153   -23.32765 1.000 18.01215 ?  149 ALA A CB  1 
ATOM   746  N N   . LEU A 1 95  ? -23.22229 2.44825   -25.73342 1.000 20.07678 ?  150 LEU A N   1 
ATOM   747  C CA  . LEU A 1 95  ? -23.07667 3.60112   -26.62001 1.000 18.78898 ?  150 LEU A CA  1 
ATOM   748  C C   . LEU A 1 95  ? -23.22524 3.19091   -28.07377 1.000 18.34750 ?  150 LEU A C   1 
ATOM   749  O O   . LEU A 1 95  ? -23.80698 3.93002   -28.87183 1.000 20.36751 ?  150 LEU A O   1 
ATOM   750  C CB  . LEU A 1 95  ? -21.72344 4.27686   -26.40191 1.000 20.01710 ?  150 LEU A CB  1 
ATOM   751  C CG  . LEU A 1 95  ? -21.43276 4.72533   -24.97076 1.000 22.43775 ?  150 LEU A CG  1 
ATOM   752  C CD1 . LEU A 1 95  ? -19.97066 5.08846   -24.85775 1.000 21.82617 ?  150 LEU A CD1 1 
ATOM   753  C CD2 . LEU A 1 95  ? -22.34546 5.90025   -24.54095 1.000 24.00490 ?  150 LEU A CD2 1 
ATOM   754  N N   . CYS A 1 96  ? -22.72391 2.00212   -28.43354 1.000 17.54331 ?  151 CYS A N   1 
ATOM   755  C CA  . CYS A 1 96  ? -22.83528 1.53056   -29.81430 1.000 17.36437 ?  151 CYS A CA  1 
ATOM   756  C C   . CYS A 1 96  ? -24.27549 1.16037   -30.15516 1.000 21.54758 ?  151 CYS A C   1 
ATOM   757  O O   . CYS A 1 96  ? -24.78494 1.50177   -31.23668 1.000 19.07483 ?  151 CYS A O   1 
ATOM   758  C CB  . CYS A 1 96  ? -21.92305 0.32255   -30.03205 1.000 23.41998 ?  151 CYS A CB  1 
ATOM   759  S SG  . CYS A 1 96  ? -20.16008 0.69866   -30.03726 1.000 20.14271 ?  151 CYS A SG  1 
ATOM   760  N N   . VAL A 1 97  ? -24.94824 0.45619   -29.24375 1.000 20.32733 ?  152 VAL A N   1 
ATOM   761  C CA  . VAL A 1 97  ? -26.35335 0.11993   -29.45637 1.000 17.61825 ?  152 VAL A CA  1 
ATOM   762  C C   . VAL A 1 97  ? -27.18056 1.39363   -29.63903 1.000 19.42173 ?  152 VAL A C   1 
ATOM   763  O O   . VAL A 1 97  ? -28.00181 1.49464   -30.55571 1.000 20.65732 ?  152 VAL A O   1 
ATOM   764  C CB  . VAL A 1 97  ? -26.87271 -0.73804  -28.29115 1.000 21.86152 ?  152 VAL A CB  1 
ATOM   765  C CG1 . VAL A 1 97  ? -28.43451 -0.77352  -28.27351 1.000 22.44204 ?  152 VAL A CG1 1 
ATOM   766  C CG2 . VAL A 1 97  ? -26.26292 -2.13734  -28.37593 1.000 17.43451 ?  152 VAL A CG2 1 
ATOM   767  N N   . GLU A 1 98  ? -26.95683 2.38505   -28.77853 1.000 20.16608 ?  153 GLU A N   1 
ATOM   768  C CA  . GLU A 1 98  ? -27.67070 3.65684   -28.90304 1.000 22.33357 ?  153 GLU A CA  1 
ATOM   769  C C   . GLU A 1 98  ? -27.40345 4.32687   -30.24757 1.000 23.98768 ?  153 GLU A C   1 
ATOM   770  O O   . GLU A 1 98  ? -28.33159 4.82780   -30.90084 1.000 25.77608 ?  153 GLU A O   1 
ATOM   771  C CB  . GLU A 1 98  ? -27.28234 4.58755   -27.76315 1.000 24.40167 ?  153 GLU A CB  1 
ATOM   772  C CG  . GLU A 1 98  ? -27.80663 6.00501   -27.99987 1.000 37.17726 ?  153 GLU A CG  1 
ATOM   773  C CD  . GLU A 1 98  ? -27.59410 6.94716   -26.82250 1.000 46.66575 ?  153 GLU A CD  1 
ATOM   774  O OE1 . GLU A 1 98  ? -26.82247 6.59486   -25.89452 1.000 51.51302 ?  153 GLU A OE1 1 
ATOM   775  O OE2 . GLU A 1 98  ? -28.19956 8.04910   -26.83528 1.000 52.95696 -1 153 GLU A OE2 1 
ATOM   776  N N   . SER A 1 99  ? -26.13359 4.37400   -30.66517 1.000 23.01642 ?  154 SER A N   1 
ATOM   777  C CA  . SER A 1 99  ? -25.77830 5.01172   -31.92799 1.000 22.94226 ?  154 SER A CA  1 
ATOM   778  C C   . SER A 1 99  ? -26.47666 4.33768   -33.10179 1.000 22.80824 ?  154 SER A C   1 
ATOM   779  O O   . SER A 1 99  ? -26.94895 5.01328   -34.02699 1.000 23.28765 ?  154 SER A O   1 
ATOM   780  C CB  . SER A 1 99  ? -24.26331 4.95885   -32.13531 1.000 22.33398 ?  154 SER A CB  1 
ATOM   781  O OG  . SER A 1 99  ? -23.57994 5.60845   -31.08256 1.000 25.09723 ?  154 SER A OG  1 
ATOM   782  N N   . VAL A 1 100 ? -26.52548 3.00232   -33.09824 1.000 18.25905 ?  155 VAL A N   1 
ATOM   783  C CA  . VAL A 1 100 ? -27.22829 2.29964   -34.16383 1.000 23.46309 ?  155 VAL A CA  1 
ATOM   784  C C   . VAL A 1 100 ? -28.73731 2.55983   -34.07448 1.000 25.88540 ?  155 VAL A C   1 
ATOM   785  O O   . VAL A 1 100 ? -29.41020 2.74790   -35.09735 1.000 24.01930 ?  155 VAL A O   1 
ATOM   786  C CB  . VAL A 1 100 ? -26.88052 0.80035   -34.12286 1.000 24.12483 ?  155 VAL A CB  1 
ATOM   787  C CG1 . VAL A 1 100 ? -27.62736 0.03760   -35.21474 1.000 27.71526 ?  155 VAL A CG1 1 
ATOM   788  C CG2 . VAL A 1 100 ? -25.36566 0.61544   -34.30514 1.000 24.59403 ?  155 VAL A CG2 1 
ATOM   789  N N   . ASP A 1 101 ? -29.28737 2.59532   -32.85903 1.000 23.06407 ?  156 ASP A N   1 
ATOM   790  C CA  . ASP A 1 101 ? -30.69811 2.94193   -32.69828 1.000 27.42449 ?  156 ASP A CA  1 
ATOM   791  C C   . ASP A 1 101 ? -31.00138 4.25776   -33.40337 1.000 31.90688 ?  156 ASP A C   1 
ATOM   792  O O   . ASP A 1 101 ? -32.02836 4.39314   -34.08143 1.000 29.49654 ?  156 ASP A O   1 
ATOM   793  C CB  . ASP A 1 101 ? -31.06496 3.06568   -31.21386 1.000 22.55839 ?  156 ASP A CB  1 
ATOM   794  C CG  . ASP A 1 101 ? -31.22702 1.72032   -30.51056 1.000 25.67400 ?  156 ASP A CG  1 
ATOM   795  O OD1 . ASP A 1 101 ? -31.25213 0.66287   -31.18408 1.000 24.12190 ?  156 ASP A OD1 1 
ATOM   796  O OD2 . ASP A 1 101 ? -31.31786 1.72907   -29.25346 1.000 23.68949 -1 156 ASP A OD2 1 
ATOM   797  N N   . LYS A 1 102 ? -30.09628 5.23124   -33.28270 1.000 25.07659 ?  157 LYS A N   1 
ATOM   798  C CA  . LYS A 1 102 ? -30.29968 6.55447   -33.85305 1.000 28.89726 ?  157 LYS A CA  1 
ATOM   799  C C   . LYS A 1 102 ? -29.75238 6.68316   -35.27109 1.000 26.80442 ?  157 LYS A C   1 
ATOM   800  O O   . LYS A 1 102 ? -29.54133 7.80206   -35.74379 1.000 33.34247 ?  157 LYS A O   1 
ATOM   801  C CB  . LYS A 1 102 ? -29.69119 7.59880   -32.92794 1.000 26.99429 ?  157 LYS A CB  1 
ATOM   802  C CG  . LYS A 1 102 ? -30.14815 7.38364   -31.49108 1.000 31.55064 ?  157 LYS A CG  1 
ATOM   803  C CD  . LYS A 1 102 ? -30.43798 8.66709   -30.75096 1.000 40.66291 ?  157 LYS A CD  1 
ATOM   804  C CE  . LYS A 1 102 ? -31.13575 8.39261   -29.41356 1.000 45.34399 ?  157 LYS A CE  1 
ATOM   805  N NZ  . LYS A 1 102 ? -32.55599 7.92388   -29.56800 1.000 42.26838 ?  157 LYS A NZ  1 
ATOM   806  N N   . GLU A 1 103 ? -29.53118 5.56406   -35.95857 1.000 24.21568 ?  158 GLU A N   1 
ATOM   807  C CA  . GLU A 1 103 ? -29.05684 5.55900   -37.34172 1.000 29.42008 ?  158 GLU A CA  1 
ATOM   808  C C   . GLU A 1 103 ? -27.75577 6.34483   -37.49557 1.000 34.55224 ?  158 GLU A C   1 
ATOM   809  O O   . GLU A 1 103 ? -27.55613 7.04774   -38.48603 1.000 33.25924 ?  158 GLU A O   1 
ATOM   810  C CB  . GLU A 1 103 ? -30.12867 6.09784   -38.29498 1.000 38.07141 ?  158 GLU A CB  1 
ATOM   811  C CG  . GLU A 1 103 ? -31.33819 5.18810   -38.43002 1.000 39.99503 ?  158 GLU A CG  1 
ATOM   812  C CD  . GLU A 1 103 ? -31.17205 4.16409   -39.54348 1.000 50.87640 ?  158 GLU A CD  1 
ATOM   813  O OE1 . GLU A 1 103 ? -30.00738 3.83898   -39.89813 1.000 52.46187 ?  158 GLU A OE1 1 
ATOM   814  O OE2 . GLU A 1 103 ? -32.20639 3.67506   -40.05809 1.000 54.27032 -1 158 GLU A OE2 1 
ATOM   815  N N   . MET A 1 104 ? -26.86258 6.22328   -36.50938 1.000 24.80187 ?  159 MET A N   1 
ATOM   816  C CA  . MET A 1 104 ? -25.53613 6.82757   -36.60660 1.000 29.79533 ?  159 MET A CA  1 
ATOM   817  C C   . MET A 1 104 ? -24.48628 5.72837   -36.49083 1.000 29.21229 ?  159 MET A C   1 
ATOM   818  O O   . MET A 1 104 ? -23.60677 5.77821   -35.62259 1.000 28.65630 ?  159 MET A O   1 
ATOM   819  C CB  . MET A 1 104 ? -25.35367 7.90140   -35.53252 1.000 30.70957 ?  159 MET A CB  1 
ATOM   820  C CG  . MET A 1 104 ? -26.37698 9.03670   -35.63023 1.000 32.68874 ?  159 MET A CG  1 
ATOM   821  S SD  . MET A 1 104 ? -26.04775 10.44685  -34.54489 1.000 42.11047 ?  159 MET A SD  1 
ATOM   822  C CE  . MET A 1 104 ? -26.28402 9.73026   -32.91323 1.000 31.51234 ?  159 MET A CE  1 
ATOM   823  N N   . GLN A 1 105 ? -24.59610 4.72404   -37.36634 1.000 26.90859 ?  160 GLN A N   1 
ATOM   824  C CA  . GLN A 1 105 ? -23.76295 3.53227   -37.29355 1.000 30.28053 ?  160 GLN A CA  1 
ATOM   825  C C   . GLN A 1 105 ? -22.26897 3.84834   -37.38665 1.000 30.70926 ?  160 GLN A C   1 
ATOM   826  O O   . GLN A 1 105 ? -21.44998 3.07057   -36.87479 1.000 27.97737 ?  160 GLN A O   1 
ATOM   827  C CB  . GLN A 1 105 ? -24.16533 2.55753   -38.40606 1.000 33.65348 ?  160 GLN A CB  1 
ATOM   828  C CG  . GLN A 1 105 ? -25.55044 1.93555   -38.26834 1.000 34.67546 ?  160 GLN A CG  1 
ATOM   829  C CD  . GLN A 1 105 ? -26.67617 2.77028   -38.92351 1.000 40.34290 ?  160 GLN A CD  1 
ATOM   830  O OE1 . GLN A 1 105 ? -26.55106 3.98717   -39.12127 1.000 37.10537 ?  160 GLN A OE1 1 
ATOM   831  N NE2 . GLN A 1 105 ? -27.77975 2.10928   -39.24621 1.000 42.48655 ?  160 GLN A NE2 1 
ATOM   832  N N   . VAL A 1 106 ? -21.88643 4.96955   -38.01251 1.000 30.64224 ?  161 VAL A N   1 
ATOM   833  C CA  . VAL A 1 106 ? -20.45840 5.27584   -38.13584 1.000 30.69683 ?  161 VAL A CA  1 
ATOM   834  C C   . VAL A 1 106 ? -19.82521 5.46955   -36.76343 1.000 28.41371 ?  161 VAL A C   1 
ATOM   835  O O   . VAL A 1 106 ? -18.63911 5.17906   -36.57124 1.000 28.33696 ?  161 VAL A O   1 
ATOM   836  C CB  . VAL A 1 106 ? -20.22828 6.51323   -39.02799 1.000 33.87308 ?  161 VAL A CB  1 
ATOM   837  C CG1 . VAL A 1 106 ? -20.69970 7.78079   -38.32413 1.000 31.85582 ?  161 VAL A CG1 1 
ATOM   838  C CG2 . VAL A 1 106 ? -18.73768 6.62597   -39.38703 1.000 35.07190 ?  161 VAL A CG2 1 
ATOM   839  N N   . LEU A 1 107 ? -20.60631 5.91057   -35.77622 1.000 26.26379 ?  162 LEU A N   1 
ATOM   840  C CA  . LEU A 1 107 ? -20.05035 6.13408   -34.44925 1.000 26.46336 ?  162 LEU A CA  1 
ATOM   841  C C   . LEU A 1 107 ? -19.57636 4.85241   -33.78547 1.000 23.23847 ?  162 LEU A C   1 
ATOM   842  O O   . LEU A 1 107 ? -18.77475 4.93387   -32.84860 1.000 24.71059 ?  162 LEU A O   1 
ATOM   843  C CB  . LEU A 1 107 ? -21.07012 6.82159   -33.54560 1.000 22.89636 ?  162 LEU A CB  1 
ATOM   844  C CG  . LEU A 1 107 ? -21.64133 8.10877   -34.12557 1.000 28.63643 ?  162 LEU A CG  1 
ATOM   845  C CD1 . LEU A 1 107 ? -22.75265 8.65226   -33.22017 1.000 25.74891 ?  162 LEU A CD1 1 
ATOM   846  C CD2 . LEU A 1 107 ? -20.53733 9.12700   -34.33688 1.000 22.24812 ?  162 LEU A CD2 1 
ATOM   847  N N   . VAL A 1 108 ? -20.05296 3.68588   -34.23747 1.000 20.52146 ?  163 VAL A N   1 
ATOM   848  C CA  . VAL A 1 108 ? -19.60268 2.41632   -33.66105 1.000 23.04374 ?  163 VAL A CA  1 
ATOM   849  C C   . VAL A 1 108 ? -18.08416 2.26992   -33.79655 1.000 23.81403 ?  163 VAL A C   1 
ATOM   850  O O   . VAL A 1 108 ? -17.38355 1.91217   -32.83921 1.000 16.81485 ?  163 VAL A O   1 
ATOM   851  C CB  . VAL A 1 108 ? -20.35196 1.23495   -34.31205 1.000 23.08011 ?  163 VAL A CB  1 
ATOM   852  C CG1 . VAL A 1 108 ? -19.77286 -0.09613  -33.84802 1.000 24.67869 ?  163 VAL A CG1 1 
ATOM   853  C CG2 . VAL A 1 108 ? -21.89901 1.31948   -34.02568 1.000 19.01924 ?  163 VAL A CG2 1 
ATOM   854  N N   . SER A 1 109 ? -17.55647 2.52269   -34.99610 1.000 23.58489 ?  164 SER A N   1 
ATOM   855  C CA  . SER A 1 109 ? -16.12166 2.38831   -35.20575 1.000 25.23255 ?  164 SER A CA  1 
ATOM   856  C C   . SER A 1 109 ? -15.34946 3.43615   -34.42508 1.000 23.79661 ?  164 SER A C   1 
ATOM   857  O O   . SER A 1 109 ? -14.21503 3.17814   -33.98586 1.000 22.75731 ?  164 SER A O   1 
ATOM   858  C CB  . SER A 1 109 ? -15.80296 2.48033   -36.69844 1.000 29.65682 ?  164 SER A CB  1 
ATOM   859  O OG  . SER A 1 109 ? -16.30029 3.69663   -37.23520 1.000 35.26444 ?  164 SER A OG  1 
ATOM   860  N N   . ARG A 1 110 ? -15.94681 4.61634   -34.25024 1.000 22.40677 ?  165 ARG A N   1 
ATOM   861  C CA  . ARG A 1 110 ? -15.35321 5.67573   -33.44625 1.000 22.47586 ?  165 ARG A CA  1 
ATOM   862  C C   . ARG A 1 110 ? -15.27123 5.27566   -31.97695 1.000 22.09060 ?  165 ARG A C   1 
ATOM   863  O O   . ARG A 1 110 ? -14.22832 5.45223   -31.33374 1.000 18.54260 ?  165 ARG A O   1 
ATOM   864  C CB  . ARG A 1 110 ? -16.17684 6.95170   -33.62002 1.000 26.13921 ?  165 ARG A CB  1 
ATOM   865  C CG  . ARG A 1 110 ? -15.58413 8.18526   -32.99681 1.000 28.73907 ?  165 ARG A CG  1 
ATOM   866  C CD  . ARG A 1 110 ? -16.44209 9.41388   -33.28711 1.000 24.79013 ?  165 ARG A CD  1 
ATOM   867  N NE  . ARG A 1 110 ? -16.49138 9.74926   -34.71331 1.000 31.63411 ?  165 ARG A NE  1 
ATOM   868  C CZ  . ARG A 1 110 ? -16.95470 10.90494  -35.20373 1.000 33.36628 ?  165 ARG A CZ  1 
ATOM   869  N NH1 . ARG A 1 110 ? -17.41671 11.83853  -34.39215 1.000 31.90771 ?  165 ARG A NH1 1 
ATOM   870  N NH2 . ARG A 1 110 ? -16.95416 11.13336  -36.51223 1.000 35.88005 ?  165 ARG A NH2 1 
ATOM   871  N N   . ILE A 1 111 ? -16.37747 4.76373   -31.42210 1.000 19.75273 ?  166 ILE A N   1 
ATOM   872  C CA  . ILE A 1 111 ? -16.39355 4.27769   -30.04361 1.000 19.31916 ?  166 ILE A CA  1 
ATOM   873  C C   . ILE A 1 111 ? -15.38863 3.14272   -29.86398 1.000 16.07939 ?  166 ILE A C   1 
ATOM   874  O O   . ILE A 1 111 ? -14.67533 3.06820   -28.85400 1.000 16.67450 ?  166 ILE A O   1 
ATOM   875  C CB  . ILE A 1 111 ? -17.82862 3.83783   -29.66329 1.000 20.32501 ?  166 ILE A CB  1 
ATOM   876  C CG1 . ILE A 1 111 ? -18.77898 5.03916   -29.69327 1.000 20.75986 ?  166 ILE A CG1 1 
ATOM   877  C CG2 . ILE A 1 111 ? -17.85915 3.15373   -28.29978 1.000 18.42277 ?  166 ILE A CG2 1 
ATOM   878  C CD1 . ILE A 1 111 ? -20.23460 4.68012   -29.96270 1.000 22.48021 ?  166 ILE A CD1 1 
ATOM   879  N N   . ALA A 1 112 ? -15.32660 2.23156   -30.82807 1.000 15.37706 ?  167 ALA A N   1 
ATOM   880  C CA  . ALA A 1 112 ? -14.37209 1.13565   -30.72505 1.000 19.19191 ?  167 ALA A CA  1 
ATOM   881  C C   . ALA A 1 112 ? -12.93125 1.65968   -30.68274 1.000 19.54608 ?  167 ALA A C   1 
ATOM   882  O O   . ALA A 1 112 ? -12.09616 1.15354   -29.92369 1.000 17.18562 ?  167 ALA A O   1 
ATOM   883  C CB  . ALA A 1 112 ? -14.56890 0.17233   -31.89168 1.000 17.93708 ?  167 ALA A CB  1 
ATOM   884  N N   . ALA A 1 113 ? -12.63467 2.70637   -31.45780 1.000 20.01684 ?  168 ALA A N   1 
ATOM   885  C CA  . ALA A 1 113 ? -11.29636 3.28484   -31.40680 1.000 21.98247 ?  168 ALA A CA  1 
ATOM   886  C C   . ALA A 1 113 ? -11.03887 3.98855   -30.07347 1.000 19.01636 ?  168 ALA A C   1 
ATOM   887  O O   . ALA A 1 113 ? -9.93196  3.90239   -29.53843 1.000 21.11105 ?  168 ALA A O   1 
ATOM   888  C CB  . ALA A 1 113 ? -11.09380 4.24187   -32.58423 1.000 22.53171 ?  168 ALA A CB  1 
ATOM   889  N N   . TRP A 1 114 ? -12.04993 4.67581   -29.50879 1.000 18.30105 ?  169 TRP A N   1 
ATOM   890  C CA  . TRP A 1 114 ? -11.87817 5.31074   -28.20103 1.000 18.50271 ?  169 TRP A CA  1 
ATOM   891  C C   . TRP A 1 114 ? -11.61712 4.28523   -27.10048 1.000 19.93180 ?  169 TRP A C   1 
ATOM   892  O O   . TRP A 1 114 ? -10.79931 4.52205   -26.20022 1.000 18.00510 ?  169 TRP A O   1 
ATOM   893  C CB  . TRP A 1 114 ? -13.11009 6.12775   -27.83849 1.000 16.94522 ?  169 TRP A CB  1 
ATOM   894  C CG  . TRP A 1 114 ? -13.36177 7.34567   -28.71201 1.000 21.68401 ?  169 TRP A CG  1 
ATOM   895  C CD1 . TRP A 1 114 ? -12.55994 7.83411   -29.70983 1.000 24.66223 ?  169 TRP A CD1 1 
ATOM   896  C CD2 . TRP A 1 114 ? -14.51269 8.19396   -28.66675 1.000 21.93121 ?  169 TRP A CD2 1 
ATOM   897  N NE1 . TRP A 1 114 ? -13.14031 8.94851   -30.27923 1.000 20.43270 ?  169 TRP A NE1 1 
ATOM   898  C CE2 . TRP A 1 114 ? -14.33941 9.18972   -29.65371 1.000 25.82723 ?  169 TRP A CE2 1 
ATOM   899  C CE3 . TRP A 1 114 ? -15.66987 8.21095   -27.88240 1.000 24.39483 ?  169 TRP A CE3 1 
ATOM   900  C CZ2 . TRP A 1 114 ? -15.27974 10.19848  -29.87530 1.000 25.33009 ?  169 TRP A CZ2 1 
ATOM   901  C CZ3 . TRP A 1 114 ? -16.62124 9.22494   -28.10398 1.000 26.43933 ?  169 TRP A CZ3 1 
ATOM   902  C CH2 . TRP A 1 114 ? -16.41167 10.20578  -29.09130 1.000 26.80623 ?  169 TRP A CH2 1 
ATOM   903  N N   . MET A 1 115 ? -12.34754 3.16940   -27.12288 1.000 16.49449 ?  170 MET A N   1 
ATOM   904  C CA  . MET A 1 115 ? -12.15308 2.12633   -26.11350 1.000 18.45209 ?  170 MET A CA  1 
ATOM   905  C C   . MET A 1 115 ? -10.75119 1.52165   -26.17444 1.000 19.18160 ?  170 MET A C   1 
ATOM   906  O O   . MET A 1 115 ? -10.13961 1.25318   -25.13639 1.000 19.71954 ?  170 MET A O   1 
ATOM   907  C CB  . MET A 1 115 ? -13.20373 1.03754   -26.30508 1.000 14.62953 ?  170 MET A CB  1 
ATOM   908  C CG  . MET A 1 115 ? -14.60958 1.50604   -25.96932 1.000 15.82883 ?  170 MET A CG  1 
ATOM   909  S SD  . MET A 1 115 ? -15.80066 0.23440   -26.38401 1.000 18.47344 ?  170 MET A SD  1 
ATOM   910  C CE  . MET A 1 115 ? -15.48258 -0.99277  -25.09242 1.000 19.97052 ?  170 MET A CE  1 
ATOM   911  N N   . ALA A 1 116 ? -10.24762 1.24738   -27.37909 1.000 18.84468 ?  171 ALA A N   1 
ATOM   912  C CA  . ALA A 1 116 ? -8.88194  0.75089   -27.53106 1.000 19.04275 ?  171 ALA A CA  1 
ATOM   913  C C   . ALA A 1 116 ? -7.85198  1.77181   -27.03573 1.000 22.68109 ?  171 ALA A C   1 
ATOM   914  O O   . ALA A 1 116 ? -6.88746  1.42128   -26.33606 1.000 18.45366 ?  171 ALA A O   1 
ATOM   915  C CB  . ALA A 1 116 ? -8.64242  0.40401   -29.00521 1.000 19.70298 ?  171 ALA A CB  1 
ATOM   916  N N   . THR A 1 117 ? -8.03583  3.04635   -27.39831 1.000 20.18362 ?  172 THR A N   1 
ATOM   917  C CA  . THR A 1 117 ? -7.14133  4.09144   -26.91204 1.000 20.22938 ?  172 THR A CA  1 
ATOM   918  C C   . THR A 1 117 ? -7.13561  4.13420   -25.39094 1.000 22.91033 ?  172 THR A C   1 
ATOM   919  O O   . THR A 1 117 ? -6.07082  4.19533   -24.76324 1.000 22.14757 ?  172 THR A O   1 
ATOM   920  C CB  . THR A 1 117 ? -7.56333  5.45385   -27.47754 1.000 22.84182 ?  172 THR A CB  1 
ATOM   921  O OG1 . THR A 1 117 ? -7.36659  5.46293   -28.89302 1.000 22.26757 ?  172 THR A OG1 1 
ATOM   922  C CG2 . THR A 1 117 ? -6.74549  6.56442   -26.86885 1.000 25.00543 ?  172 THR A CG2 1 
ATOM   923  N N   . TYR A 1 118 ? -8.31733  4.10646   -24.77418 1.000 17.92124 ?  173 TYR A N   1 
ATOM   924  C CA  . TYR A 1 118 ? -8.38092  4.18190   -23.31636 1.000 17.40247 ?  173 TYR A CA  1 
ATOM   925  C C   . TYR A 1 118 ? -7.71151  2.96969   -22.67112 1.000 18.87267 ?  173 TYR A C   1 
ATOM   926  O O   . TYR A 1 118 ? -6.97072  3.10371   -21.68738 1.000 19.63850 ?  173 TYR A O   1 
ATOM   927  C CB  . TYR A 1 118 ? -9.83579  4.29554   -22.83284 1.000 18.63039 ?  173 TYR A CB  1 
ATOM   928  C CG  . TYR A 1 118 ? -9.86759  4.72806   -21.37545 1.000 21.05717 ?  173 TYR A CG  1 
ATOM   929  C CD1 . TYR A 1 118 ? -9.66624  3.80187   -20.34866 1.000 17.87320 ?  173 TYR A CD1 1 
ATOM   930  C CD2 . TYR A 1 118 ? -10.01543 6.06842   -21.03320 1.000 22.48337 ?  173 TYR A CD2 1 
ATOM   931  C CE1 . TYR A 1 118 ? -9.63371  4.19828   -19.04723 1.000 19.03920 ?  173 TYR A CE1 1 
ATOM   932  C CE2 . TYR A 1 118 ? -10.00316 6.47508   -19.71604 1.000 18.98866 ?  173 TYR A CE2 1 
ATOM   933  C CZ  . TYR A 1 118 ? -9.82009  5.53348   -18.73553 1.000 21.51199 ?  173 TYR A CZ  1 
ATOM   934  O OH  . TYR A 1 118 ? -9.80017  5.92435   -17.41999 1.000 21.59276 ?  173 TYR A OH  1 
ATOM   935  N N   . LEU A 1 119 ? -8.01998  1.76883   -23.16870 1.000 19.13580 ?  174 LEU A N   1 
ATOM   936  C CA  . LEU A 1 119 ? -7.37119  0.57145   -22.64837 1.000 20.83846 ?  174 LEU A CA  1 
ATOM   937  C C   . LEU A 1 119 ? -5.85190  0.69403   -22.74341 1.000 23.71813 ?  174 LEU A C   1 
ATOM   938  O O   . LEU A 1 119 ? -5.12128  0.43281   -21.77660 1.000 19.91980 ?  174 LEU A O   1 
ATOM   939  C CB  . LEU A 1 119 ? -7.85552  -0.63965  -23.42756 1.000 22.15604 ?  174 LEU A CB  1 
ATOM   940  C CG  . LEU A 1 119 ? -9.18031  -1.26094  -22.97858 1.000 22.39659 ?  174 LEU A CG  1 
ATOM   941  C CD1 . LEU A 1 119 ? -9.84926  -1.92683  -24.17161 1.000 17.80530 ?  174 LEU A CD1 1 
ATOM   942  C CD2 . LEU A 1 119 ? -8.93451  -2.27141  -21.84402 1.000 19.85366 ?  174 LEU A CD2 1 
ATOM   943  N N   . ASN A 1 120 ? -5.35784  1.11228   -23.90142 1.000 19.69447 ?  175 ASN A N   1 
ATOM   944  C CA  . ASN A 1 120 ? -3.91493  1.08884   -24.08780 1.000 24.42067 ?  175 ASN A CA  1 
ATOM   945  C C   . ASN A 1 120 ? -3.22600  2.20704   -23.30948 1.000 22.89649 ?  175 ASN A C   1 
ATOM   946  O O   . ASN A 1 120 ? -2.13999  1.99424   -22.76925 1.000 27.26846 ?  175 ASN A O   1 
ATOM   947  C CB  . ASN A 1 120 ? -3.59083  1.11829   -25.58850 1.000 25.61287 ?  175 ASN A CB  1 
ATOM   948  C CG  . ASN A 1 120 ? -3.90863  -0.22248  -26.27266 1.000 29.29870 ?  175 ASN A CG  1 
ATOM   949  O OD1 . ASN A 1 120 ? -3.87283  -1.28962  -25.63623 1.000 30.35204 ?  175 ASN A OD1 1 
ATOM   950  N ND2 . ASN A 1 120 ? -4.23462  -0.17170  -27.55787 1.000 30.15232 ?  175 ASN A ND2 1 
ATOM   951  N N   . ASP A 1 121 ? -3.86243  3.36013   -23.15427 1.000 23.33253 ?  176 ASP A N   1 
ATOM   952  C CA  . ASP A 1 121 ? -3.22125  4.45107   -22.42682 1.000 24.78748 ?  176 ASP A CA  1 
ATOM   953  C C   . ASP A 1 121 ? -3.41700  4.37659   -20.91671 1.000 30.04436 ?  176 ASP A C   1 
ATOM   954  O O   . ASP A 1 121 ? -2.50616  4.74888   -20.17040 1.000 27.89103 ?  176 ASP A O   1 
ATOM   955  C CB  . ASP A 1 121 ? -3.74533  5.81339   -22.90806 1.000 28.26036 ?  176 ASP A CB  1 
ATOM   956  C CG  . ASP A 1 121 ? -3.36723  6.12051   -24.35093 1.000 30.28389 ?  176 ASP A CG  1 
ATOM   957  O OD1 . ASP A 1 121 ? -2.52119  5.39663   -24.92520 1.000 38.30430 ?  176 ASP A OD1 1 
ATOM   958  O OD2 . ASP A 1 121 ? -3.91079  7.10356   -24.91104 1.000 34.86102 -1 176 ASP A OD2 1 
ATOM   959  N N   . HIS A 1 122 ? -4.57532  3.92372   -20.43715 1.000 21.76610 ?  177 HIS A N   1 
ATOM   960  C CA  . HIS A 1 122 ? -4.89518  3.99274   -19.01176 1.000 23.06514 ?  177 HIS A CA  1 
ATOM   961  C C   . HIS A 1 122 ? -4.87681  2.65215   -18.29792 1.000 25.10787 ?  177 HIS A C   1 
ATOM   962  O O   . HIS A 1 122 ? -4.62509  2.60929   -17.09182 1.000 27.15423 ?  177 HIS A O   1 
ATOM   963  C CB  . HIS A 1 122 ? -6.29023  4.59347   -18.79722 1.000 20.62729 ?  177 HIS A CB  1 
ATOM   964  C CG  . HIS A 1 122 ? -6.41019  6.02925   -19.19215 1.000 25.27498 ?  177 HIS A CG  1 
ATOM   965  N ND1 . HIS A 1 122 ? -6.33859  7.05875   -18.27684 1.000 29.90108 ?  177 HIS A ND1 1 
ATOM   966  C CD2 . HIS A 1 122 ? -6.63788  6.60994   -20.39433 1.000 25.31042 ?  177 HIS A CD2 1 
ATOM   967  C CE1 . HIS A 1 122 ? -6.50380  8.21174   -18.90036 1.000 31.70344 ?  177 HIS A CE1 1 
ATOM   968  N NE2 . HIS A 1 122 ? -6.67787  7.96817   -20.18762 1.000 30.23158 ?  177 HIS A NE2 1 
ATOM   969  N N   . LEU A 1 123 ? -5.17309  1.56108   -18.99052 1.000 22.90757 ?  178 LEU A N   1 
ATOM   970  C CA  . LEU A 1 123 ? -5.46542  0.30101   -18.32027 1.000 22.07242 ?  178 LEU A CA  1 
ATOM   971  C C   . LEU A 1 123 ? -4.42036  -0.77278  -18.55963 1.000 21.56868 ?  178 LEU A C   1 
ATOM   972  O O   . LEU A 1 123 ? -4.28077  -1.67704  -17.72630 1.000 21.44314 ?  178 LEU A O   1 
ATOM   973  C CB  . LEU A 1 123 ? -6.84986  -0.23728  -18.77426 1.000 18.02032 ?  178 LEU A CB  1 
ATOM   974  C CG  . LEU A 1 123 ? -8.08438  0.58605   -18.39560 1.000 21.24668 ?  178 LEU A CG  1 
ATOM   975  C CD1 . LEU A 1 123 ? -9.39380  -0.06529  -18.88313 1.000 17.09190 ?  178 LEU A CD1 1 
ATOM   976  C CD2 . LEU A 1 123 ? -8.15580  0.81538   -16.88616 1.000 22.16250 ?  178 LEU A CD2 1 
ATOM   977  N N   . GLU A 1 124 ? -3.68368  -0.69236  -19.66578 1.000 24.35106 ?  179 GLU A N   1 
ATOM   978  C CA  . GLU A 1 124 ? -2.76113  -1.76300  -20.02295 1.000 27.26817 ?  179 GLU A CA  1 
ATOM   979  C C   . GLU A 1 124 ? -1.63404  -1.98086  -19.00860 1.000 24.38166 ?  179 GLU A C   1 
ATOM   980  O O   . GLU A 1 124 ? -1.29238  -3.14769  -18.76674 1.000 22.01687 ?  179 GLU A O   1 
ATOM   981  C CB  . GLU A 1 124 ? -2.19697  -1.50662  -21.43151 1.000 29.57574 ?  179 GLU A CB  1 
ATOM   982  C CG  . GLU A 1 124 ? -1.15744  -2.53409  -21.89893 1.000 31.51408 ?  179 GLU A CG  1 
ATOM   983  C CD  . GLU A 1 124 ? -1.70731  -3.96617  -21.99607 1.000 37.71160 ?  179 GLU A CD  1 
ATOM   984  O OE1 . GLU A 1 124 ? -2.93861  -4.13762  -22.17751 1.000 37.66672 ?  179 GLU A OE1 1 
ATOM   985  O OE2 . GLU A 1 124 ? -0.90140  -4.92808  -21.88824 1.000 39.37315 -1 179 GLU A OE2 1 
ATOM   986  N N   . PRO A 1 125 ? -1.02898  -0.94672  -18.39732 1.000 25.45199 ?  180 PRO A N   1 
ATOM   987  C CA  . PRO A 1 125 ? -0.06590  -1.23198  -17.31091 1.000 24.21596 ?  180 PRO A CA  1 
ATOM   988  C C   . PRO A 1 125 ? -0.66947  -2.00406  -16.14782 1.000 25.76733 ?  180 PRO A C   1 
ATOM   989  O O   . PRO A 1 125 ? -0.01250  -2.89832  -15.59175 1.000 26.96143 ?  180 PRO A O   1 
ATOM   990  C CB  . PRO A 1 125 ? 0.38330   0.16745   -16.87416 1.000 26.53144 ?  180 PRO A CB  1 
ATOM   991  C CG  . PRO A 1 125 ? 0.23034   0.98608   -18.08844 1.000 31.52811 ?  180 PRO A CG  1 
ATOM   992  C CD  . PRO A 1 125 ? -1.04796  0.49186   -18.71956 1.000 24.47694 ?  180 PRO A CD  1 
ATOM   993  N N   . TRP A 1 126 ? -1.88728  -1.65328  -15.73747 1.000 23.43414 ?  181 TRP A N   1 
ATOM   994  C CA  . TRP A 1 126 ? -2.56671  -2.39810  -14.68269 1.000 19.85063 ?  181 TRP A CA  1 
ATOM   995  C C   . TRP A 1 126 ? -2.85670  -3.81955  -15.12678 1.000 20.82678 ?  181 TRP A C   1 
ATOM   996  O O   . TRP A 1 126 ? -2.65249  -4.77016  -14.36678 1.000 19.73687 ?  181 TRP A O   1 
ATOM   997  C CB  . TRP A 1 126 ? -3.86929  -1.69831  -14.28488 1.000 24.46721 ?  181 TRP A CB  1 
ATOM   998  C CG  . TRP A 1 126 ? -4.59495  -2.37345  -13.13059 1.000 22.65884 ?  181 TRP A CG  1 
ATOM   999  C CD1 . TRP A 1 126 ? -4.52911  -2.01766  -11.80839 1.000 23.44271 ?  181 TRP A CD1 1 
ATOM   1000 C CD2 . TRP A 1 126 ? -5.51769  -3.47968  -13.20097 1.000 22.40566 ?  181 TRP A CD2 1 
ATOM   1001 N NE1 . TRP A 1 126 ? -5.32296  -2.84166  -11.05705 1.000 22.74465 ?  181 TRP A NE1 1 
ATOM   1002 C CE2 . TRP A 1 126 ? -5.93310  -3.75696  -11.88291 1.000 21.51284 ?  181 TRP A CE2 1 
ATOM   1003 C CE3 . TRP A 1 126 ? -6.00995  -4.28215  -14.24839 1.000 21.39273 ?  181 TRP A CE3 1 
ATOM   1004 C CZ2 . TRP A 1 126 ? -6.82178  -4.78879  -11.58058 1.000 24.18162 ?  181 TRP A CZ2 1 
ATOM   1005 C CZ3 . TRP A 1 126 ? -6.89314  -5.31886  -13.94142 1.000 20.73628 ?  181 TRP A CZ3 1 
ATOM   1006 C CH2 . TRP A 1 126 ? -7.29656  -5.55555  -12.62627 1.000 21.37090 ?  181 TRP A CH2 1 
ATOM   1007 N N   . ILE A 1 127 ? -3.35320  -3.98749  -16.35171 1.000 19.65085 ?  182 ILE A N   1 
ATOM   1008 C CA  . ILE A 1 127 ? -3.61305  -5.33175  -16.85163 1.000 20.40904 ?  182 ILE A CA  1 
ATOM   1009 C C   . ILE A 1 127 ? -2.33149  -6.17504  -16.81905 1.000 21.99793 ?  182 ILE A C   1 
ATOM   1010 O O   . ILE A 1 127 ? -2.33393  -7.33224  -16.37521 1.000 21.38793 ?  182 ILE A O   1 
ATOM   1011 C CB  . ILE A 1 127 ? -4.22132  -5.24097  -18.26117 1.000 23.22095 ?  182 ILE A CB  1 
ATOM   1012 C CG1 . ILE A 1 127 ? -5.64840  -4.63134  -18.17735 1.000 20.28204 ?  182 ILE A CG1 1 
ATOM   1013 C CG2 . ILE A 1 127 ? -4.20882  -6.60875  -18.91834 1.000 22.01747 ?  182 ILE A CG2 1 
ATOM   1014 C CD1 . ILE A 1 127 ? -6.30563  -4.40732  -19.52870 1.000 22.78100 ?  182 ILE A CD1 1 
ATOM   1015 N N   . GLN A 1 128 ? -1.20216  -5.59117  -17.22861 1.000 21.01326 ?  183 GLN A N   1 
ATOM   1016 C CA  . GLN A 1 128 ? 0.04553   -6.35899  -17.21133 1.000 25.84779 ?  183 GLN A CA  1 
ATOM   1017 C C   . GLN A 1 128 ? 0.47578   -6.70210  -15.79213 1.000 23.04624 ?  183 GLN A C   1 
ATOM   1018 O O   . GLN A 1 128 ? 0.89779   -7.83314  -15.52191 1.000 26.95572 ?  183 GLN A O   1 
ATOM   1019 C CB  . GLN A 1 128 ? 1.14291   -5.59345  -17.91748 1.000 22.70606 ?  183 GLN A CB  1 
ATOM   1020 C CG  . GLN A 1 128 ? 1.14933   -5.75130  -19.40775 1.000 28.19873 ?  183 GLN A CG  1 
ATOM   1021 C CD  . GLN A 1 128 ? 2.20188   -4.85479  -20.01980 1.000 32.66989 ?  183 GLN A CD  1 
ATOM   1022 O OE1 . GLN A 1 128 ? 3.24080   -4.58211  -19.39910 1.000 27.88218 ?  183 GLN A OE1 1 
ATOM   1023 N NE2 . GLN A 1 128 ? 1.93130   -4.36522  -21.22023 1.000 34.35360 ?  183 GLN A NE2 1 
ATOM   1024 N N   . GLU A 1 129 ? 0.39762   -5.73214  -14.87965 1.000 22.66418 ?  184 GLU A N   1 
ATOM   1025 C CA  . GLU A 1 129 ? 0.76688   -5.95766  -13.47896 1.000 26.56657 ?  184 GLU A CA  1 
ATOM   1026 C C   . GLU A 1 129 ? -0.04981  -7.07997  -12.84385 1.000 29.16357 ?  184 GLU A C   1 
ATOM   1027 O O   . GLU A 1 129 ? 0.44538   -7.77664  -11.95641 1.000 28.01348 ?  184 GLU A O   1 
ATOM   1028 C CB  . GLU A 1 129 ? 0.57242   -4.66938  -12.66816 1.000 26.41546 ?  184 GLU A CB  1 
ATOM   1029 C CG  . GLU A 1 129 ? 1.78007   -3.71138  -12.63028 1.000 38.77796 ?  184 GLU A CG  1 
ATOM   1030 C CD  . GLU A 1 129 ? 3.13371   -4.45853  -12.56139 1.000 52.55562 ?  184 GLU A CD  1 
ATOM   1031 O OE1 . GLU A 1 129 ? 3.97948   -4.26613  -13.47567 1.000 48.73501 ?  184 GLU A OE1 1 
ATOM   1032 O OE2 . GLU A 1 129 ? 3.36396   -5.23343  -11.59604 1.000 56.01438 -1 184 GLU A OE2 1 
ATOM   1033 N N   . ASN A 1 130 ? -1.30412  -7.25157  -13.26585 1.000 26.50667 ?  185 ASN A N   1 
ATOM   1034 C CA  . ASN A 1 130 ? -2.19000  -8.25706  -12.69954 1.000 26.36905 ?  185 ASN A CA  1 
ATOM   1035 C C   . ASN A 1 130 ? -2.21608  -9.55350  -13.49014 1.000 27.56901 ?  185 ASN A C   1 
ATOM   1036 O O   . ASN A 1 130 ? -3.12306  -10.36814 -13.29523 1.000 32.45262 ?  185 ASN A O   1 
ATOM   1037 C CB  . ASN A 1 130 ? -3.59783  -7.68887  -12.58120 1.000 25.61546 ?  185 ASN A CB  1 
ATOM   1038 C CG  . ASN A 1 130 ? -3.71346  -6.70991  -11.44229 1.000 27.63484 ?  185 ASN A CG  1 
ATOM   1039 O OD1 . ASN A 1 130 ? -4.32633  -7.01669  -10.42372 1.000 35.20880 ?  185 ASN A OD1 1 
ATOM   1040 N ND2 . ASN A 1 130 ? -3.07737  -5.54059  -11.58280 1.000 26.14231 ?  185 ASN A ND2 1 
ATOM   1041 N N   . GLY A 1 131 ? -1.25102  -9.77021  -14.36902 1.000 26.42023 ?  186 GLY A N   1 
ATOM   1042 C CA  . GLY A 1 131 ? -1.09350  -11.04613 -15.02304 1.000 28.45783 ?  186 GLY A CA  1 
ATOM   1043 C C   . GLY A 1 131 ? -1.74557  -11.16253 -16.37518 1.000 29.37257 ?  186 GLY A C   1 
ATOM   1044 O O   . GLY A 1 131 ? -1.84693  -12.27834 -16.89841 1.000 32.97617 ?  186 GLY A O   1 
ATOM   1045 N N   . GLY A 1 132 ? -2.19154  -10.05831 -16.95998 1.000 25.67521 ?  187 GLY A N   1 
ATOM   1046 C CA  . GLY A 1 132 ? -2.78693  -10.11643 -18.27618 1.000 22.17735 ?  187 GLY A CA  1 
ATOM   1047 C C   . GLY A 1 132 ? -4.20060  -10.65106 -18.23980 1.000 24.59599 ?  187 GLY A C   1 
ATOM   1048 O O   . GLY A 1 132 ? -4.75688  -10.98876 -17.19628 1.000 23.09291 ?  187 GLY A O   1 
ATOM   1049 N N   . TRP A 1 133 ? -4.79104  -10.73808 -19.43204 1.000 20.86615 ?  188 TRP A N   1 
ATOM   1050 C CA  . TRP A 1 133 ? -6.18086  -11.15572 -19.55093 1.000 26.31660 ?  188 TRP A CA  1 
ATOM   1051 C C   . TRP A 1 133 ? -6.40929  -12.59285 -19.09026 1.000 25.34726 ?  188 TRP A C   1 
ATOM   1052 O O   . TRP A 1 133 ? -7.53945  -12.94019 -18.74435 1.000 22.48330 ?  188 TRP A O   1 
ATOM   1053 C CB  . TRP A 1 133 ? -6.64638  -10.94514 -21.00117 1.000 25.81483 ?  188 TRP A CB  1 
ATOM   1054 C CG  . TRP A 1 133 ? -6.99416  -9.50687  -21.28256 1.000 23.39389 ?  188 TRP A CG  1 
ATOM   1055 C CD1 . TRP A 1 133 ? -6.23055  -8.57897  -21.94312 1.000 25.45859 ?  188 TRP A CD1 1 
ATOM   1056 C CD2 . TRP A 1 133 ? -8.18627  -8.82262  -20.87057 1.000 23.25791 ?  188 TRP A CD2 1 
ATOM   1057 N NE1 . TRP A 1 133 ? -6.89020  -7.36285  -21.97675 1.000 23.77918 ?  188 TRP A NE1 1 
ATOM   1058 C CE2 . TRP A 1 133 ? -8.08768  -7.48985  -21.32208 1.000 24.96414 ?  188 TRP A CE2 1 
ATOM   1059 C CE3 . TRP A 1 133 ? -9.33137  -9.21320  -20.17629 1.000 23.47833 ?  188 TRP A CE3 1 
ATOM   1060 C CZ2 . TRP A 1 133 ? -9.09755  -6.55561  -21.11336 1.000 22.52570 ?  188 TRP A CZ2 1 
ATOM   1061 C CZ3 . TRP A 1 133 ? -10.32931 -8.28091  -19.96215 1.000 24.54902 ?  188 TRP A CZ3 1 
ATOM   1062 C CH2 . TRP A 1 133 ? -10.20520 -6.96830  -20.42561 1.000 23.81373 ?  188 TRP A CH2 1 
ATOM   1063 N N   . ASP A 1 134 ? -5.37176  -13.43498 -19.04283 1.000 23.18962 ?  189 ASP A N   1 
ATOM   1064 C CA  . ASP A 1 134 ? -5.57572  -14.78841 -18.51313 1.000 26.07835 ?  189 ASP A CA  1 
ATOM   1065 C C   . ASP A 1 134 ? -6.02867  -14.77295 -17.05805 1.000 23.84425 ?  189 ASP A C   1 
ATOM   1066 O O   . ASP A 1 134 ? -6.78914  -15.65088 -16.64173 1.000 28.15689 ?  189 ASP A O   1 
ATOM   1067 C CB  . ASP A 1 134 ? -4.29880  -15.62188 -18.63707 1.000 33.54115 ?  189 ASP A CB  1 
ATOM   1068 C CG  . ASP A 1 134 ? -3.93809  -15.91320 -20.08217 1.000 47.02391 ?  189 ASP A CG  1 
ATOM   1069 O OD1 . ASP A 1 134 ? -4.86165  -15.88634 -20.94112 1.000 47.29402 ?  189 ASP A OD1 1 
ATOM   1070 O OD2 . ASP A 1 134 ? -2.73432  -16.15816 -20.35562 1.000 56.31513 -1 189 ASP A OD2 1 
ATOM   1071 N N   . THR A 1 135 ? -5.57955  -13.79698 -16.26929 1.000 26.94232 ?  190 THR A N   1 
ATOM   1072 C CA  . THR A 1 135 ? -6.05991  -13.68617 -14.88825 1.000 24.57183 ?  190 THR A CA  1 
ATOM   1073 C C   . THR A 1 135 ? -7.56686  -13.44741 -14.82702 1.000 27.43814 ?  190 THR A C   1 
ATOM   1074 O O   . THR A 1 135 ? -8.25971  -14.02116 -13.97265 1.000 25.06651 ?  190 THR A O   1 
ATOM   1075 C CB  . THR A 1 135 ? -5.32392  -12.56767 -14.16532 1.000 26.33690 ?  190 THR A CB  1 
ATOM   1076 O OG1 . THR A 1 135 ? -3.92122  -12.86827 -14.14146 1.000 25.54188 ?  190 THR A OG1 1 
ATOM   1077 C CG2 . THR A 1 135 ? -5.85926  -12.42594 -12.73727 1.000 25.84895 ?  190 THR A CG2 1 
ATOM   1078 N N   . PHE A 1 136 ? -8.08519  -12.57923 -15.70673 1.000 20.42152 ?  191 PHE A N   1 
ATOM   1079 C CA  . PHE A 1 136 ? -9.52240  -12.35804 -15.79024 1.000 23.47095 ?  191 PHE A CA  1 
ATOM   1080 C C   . PHE A 1 136 ? -10.26511 -13.66594 -16.03737 1.000 22.15734 ?  191 PHE A C   1 
ATOM   1081 O O   . PHE A 1 136 ? -11.26437 -13.96259 -15.37267 1.000 22.49821 ?  191 PHE A O   1 
ATOM   1082 C CB  . PHE A 1 136 ? -9.82730  -11.34758 -16.90459 1.000 22.57914 ?  191 PHE A CB  1 
ATOM   1083 C CG  . PHE A 1 136 ? -11.31282 -11.15040 -17.15918 1.000 23.69113 ?  191 PHE A CG  1 
ATOM   1084 C CD1 . PHE A 1 136 ? -12.09877 -10.43647 -16.25862 1.000 22.12456 ?  191 PHE A CD1 1 
ATOM   1085 C CD2 . PHE A 1 136 ? -11.91670 -11.68475 -18.27973 1.000 25.29866 ?  191 PHE A CD2 1 
ATOM   1086 C CE1 . PHE A 1 136 ? -13.45314 -10.26203 -16.47488 1.000 19.81872 ?  191 PHE A CE1 1 
ATOM   1087 C CE2 . PHE A 1 136 ? -13.28317 -11.50663 -18.50434 1.000 22.06987 ?  191 PHE A CE2 1 
ATOM   1088 C CZ  . PHE A 1 136 ? -14.03950 -10.79100 -17.59717 1.000 20.87658 ?  191 PHE A CZ  1 
ATOM   1089 N N   . VAL A 1 137 ? -9.79594  -14.45526 -17.00656 1.000 21.26499 ?  192 VAL A N   1 
ATOM   1090 C CA  . VAL A 1 137 ? -10.44294 -15.73158 -17.32106 1.000 26.18259 ?  192 VAL A CA  1 
ATOM   1091 C C   . VAL A 1 137 ? -10.43725 -16.65895 -16.10958 1.000 25.35629 ?  192 VAL A C   1 
ATOM   1092 O O   . VAL A 1 137 ? -11.45542 -17.27587 -15.77886 1.000 25.02109 ?  192 VAL A O   1 
ATOM   1093 C CB  . VAL A 1 137 ? -9.76610  -16.39639 -18.53286 1.000 26.28349 ?  192 VAL A CB  1 
ATOM   1094 C CG1 . VAL A 1 137 ? -10.34820 -17.78419 -18.75401 1.000 30.17223 ?  192 VAL A CG1 1 
ATOM   1095 C CG2 . VAL A 1 137 ? -9.94805  -15.54700 -19.76501 1.000 25.59952 ?  192 VAL A CG2 1 
ATOM   1096 N N   . GLU A 1 138 ? -9.29298  -16.76988 -15.42584 1.000 25.39301 ?  193 GLU A N   1 
ATOM   1097 C CA  . GLU A 1 138 ? -9.20199  -17.69488 -14.29556 1.000 28.69396 ?  193 GLU A CA  1 
ATOM   1098 C C   . GLU A 1 138 ? -10.15113 -17.30027 -13.17842 1.000 29.38608 ?  193 GLU A C   1 
ATOM   1099 O O   . GLU A 1 138 ? -10.70507 -18.16405 -12.48848 1.000 27.19545 ?  193 GLU A O   1 
ATOM   1100 C CB  . GLU A 1 138 ? -7.77141  -17.75407 -13.75099 1.000 22.91477 ?  193 GLU A CB  1 
ATOM   1101 C CG  . GLU A 1 138 ? -6.74319  -18.25371 -14.73389 1.000 25.20090 ?  193 GLU A CG  1 
ATOM   1102 C CD  . GLU A 1 138 ? -6.93416  -19.71941 -15.13406 1.000 35.28514 ?  193 GLU A CD  1 
ATOM   1103 O OE1 . GLU A 1 138 ? -7.79489  -20.41284 -14.56093 1.000 36.96019 ?  193 GLU A OE1 1 
ATOM   1104 O OE2 . GLU A 1 138 ? -6.20998  -20.18653 -16.04004 1.000 45.66356 -1 193 GLU A OE2 1 
ATOM   1105 N N   . LEU A 1 139 ? -10.33441 -15.99885 -12.96787 1.000 23.81358 ?  194 LEU A N   1 
ATOM   1106 C CA  . LEU A 1 139 ? -11.20297 -15.55240 -11.88982 1.000 25.51570 ?  194 LEU A CA  1 
ATOM   1107 C C   . LEU A 1 139 ? -12.66933 -15.61528 -12.25832 1.000 28.22847 ?  194 LEU A C   1 
ATOM   1108 O O   . LEU A 1 139 ? -13.52448 -15.78785 -11.38015 1.000 29.62985 ?  194 LEU A O   1 
ATOM   1109 C CB  . LEU A 1 139 ? -10.85479 -14.12396 -11.49942 1.000 26.13715 ?  194 LEU A CB  1 
ATOM   1110 C CG  . LEU A 1 139 ? -9.52103  -13.92021 -10.80429 1.000 24.78711 ?  194 LEU A CG  1 
ATOM   1111 C CD1 . LEU A 1 139 ? -9.22213  -12.43263 -10.72737 1.000 25.28972 ?  194 LEU A CD1 1 
ATOM   1112 C CD2 . LEU A 1 139 ? -9.59688  -14.55455 -9.41580  1.000 29.09582 ?  194 LEU A CD2 1 
ATOM   1113 N N   . TYR A 1 140 ? -12.99792 -15.43955 -13.52559 1.000 27.61424 ?  195 TYR A N   1 
ATOM   1114 C CA  . TYR A 1 140 ? -14.41348 -15.42911 -13.84249 1.000 32.15818 ?  195 TYR A CA  1 
ATOM   1115 C C   . TYR A 1 140 ? -14.97191 -16.84296 -13.94422 1.000 36.02098 ?  195 TYR A C   1 
ATOM   1116 O O   . TYR A 1 140 ? -16.13515 -17.07089 -13.58875 1.000 31.38256 ?  195 TYR A O   1 
ATOM   1117 C CB  . TYR A 1 140 ? -14.68082 -14.63332 -15.12833 1.000 27.70405 ?  195 TYR A CB  1 
ATOM   1118 C CG  . TYR A 1 140 ? -16.15494 -14.53213 -15.39646 1.000 30.46872 ?  195 TYR A CG  1 
ATOM   1119 C CD1 . TYR A 1 140 ? -16.98710 -13.83173 -14.53276 1.000 29.61806 ?  195 TYR A CD1 1 
ATOM   1120 C CD2 . TYR A 1 140 ? -16.72592 -15.17529 -16.48791 1.000 30.46106 ?  195 TYR A CD2 1 
ATOM   1121 C CE1 . TYR A 1 140 ? -18.35592 -13.76163 -14.75314 1.000 30.59221 ?  195 TYR A CE1 1 
ATOM   1122 C CE2 . TYR A 1 140 ? -18.08898 -15.10767 -16.71999 1.000 31.88050 ?  195 TYR A CE2 1 
ATOM   1123 C CZ  . TYR A 1 140 ? -18.89471 -14.39332 -15.85339 1.000 28.89516 ?  195 TYR A CZ  1 
ATOM   1124 O OH  . TYR A 1 140 ? -20.24450 -14.34102 -16.08784 1.000 37.90203 ?  195 TYR A OH  1 
ATOM   1125 N N   . GLY A 1 141 ? -14.14879 -17.79971 -14.36619 1.000 37.49605 ?  196 GLY A N   1 
ATOM   1126 C CA  . GLY A 1 141 ? -14.60338 -19.14190 -14.66178 1.000 41.86351 ?  196 GLY A CA  1 
ATOM   1127 C C   . GLY A 1 141 ? -14.41623 -19.43247 -16.14066 1.000 47.97341 ?  196 GLY A C   1 
ATOM   1128 O O   . GLY A 1 141 ? -13.81476 -18.62812 -16.86922 1.000 46.86905 ?  196 GLY A O   1 
ATOM   1129 N N   . GLN B 1 3   ? -2.91534  -9.68605  -24.34831 1.000 56.66310 ?  3   GLN B N   1 
ATOM   1130 C CA  . GLN B 1 3   ? -2.89874  -9.60194  -25.80719 1.000 49.69584 ?  3   GLN B CA  1 
ATOM   1131 C C   . GLN B 1 3   ? -3.81212  -8.45873  -26.28066 1.000 42.56127 ?  3   GLN B C   1 
ATOM   1132 O O   . GLN B 1 3   ? -4.03395  -7.50929  -25.50797 1.000 41.48087 ?  3   GLN B O   1 
ATOM   1133 C CB  . GLN B 1 3   ? -3.30075  -10.93183 -26.43445 1.000 51.57806 ?  3   GLN B CB  1 
ATOM   1134 C CG  . GLN B 1 3   ? -2.67414  -11.24854 -27.78471 1.000 59.49272 ?  3   GLN B CG  1 
ATOM   1135 C CD  . GLN B 1 3   ? -1.36695  -12.00474 -27.64648 1.000 45.40299 ?  3   GLN B CD  1 
ATOM   1136 O OE1 . GLN B 1 3   ? -1.34075  -13.23609 -27.63398 1.000 45.91726 ?  3   GLN B OE1 1 
ATOM   1137 N NE2 . GLN B 1 3   ? -0.27301  -11.26639 -27.53064 1.000 48.81083 ?  3   GLN B NE2 1 
ATOM   1138 N N   . SER B 1 4   ? -4.34257  -8.55214  -27.51442 1.000 38.49736 ?  4   SER B N   1 
ATOM   1139 C CA  . SER B 1 4   ? -4.77755  -7.35615  -28.25326 1.000 35.87829 ?  4   SER B CA  1 
ATOM   1140 C C   . SER B 1 4   ? -6.07455  -6.76636  -27.70443 1.000 31.63720 ?  4   SER B C   1 
ATOM   1141 O O   . SER B 1 4   ? -7.16823  -7.30603  -27.92583 1.000 28.93620 ?  4   SER B O   1 
ATOM   1142 C CB  . SER B 1 4   ? -4.93927  -7.66520  -29.73280 1.000 33.87009 ?  4   SER B CB  1 
ATOM   1143 O OG  . SER B 1 4   ? -5.43012  -6.50812  -30.41771 1.000 32.78043 ?  4   SER B OG  1 
ATOM   1144 N N   . ASN B 1 5   ? -5.95609  -5.61524  -27.04289 1.000 30.32444 ?  5   ASN B N   1 
ATOM   1145 C CA  . ASN B 1 5   ? -7.13396  -4.87662  -26.59654 1.000 26.73844 ?  5   ASN B CA  1 
ATOM   1146 C C   . ASN B 1 5   ? -8.07225  -4.54156  -27.76190 1.000 30.90140 ?  5   ASN B C   1 
ATOM   1147 O O   . ASN B 1 5   ? -9.29656  -4.60024  -27.61062 1.000 29.93278 ?  5   ASN B O   1 
ATOM   1148 C CB  . ASN B 1 5   ? -6.69855  -3.60017  -25.86108 1.000 25.09462 ?  5   ASN B CB  1 
ATOM   1149 C CG  . ASN B 1 5   ? -5.95502  -3.89530  -24.54582 1.000 31.28523 ?  5   ASN B CG  1 
ATOM   1150 O OD1 . ASN B 1 5   ? -6.26152  -4.85852  -23.84960 1.000 34.34641 ?  5   ASN B OD1 1 
ATOM   1151 N ND2 . ASN B 1 5   ? -4.96810  -3.06648  -24.21898 1.000 30.53214 ?  5   ASN B ND2 1 
ATOM   1152 N N   . ARG B 1 6   ? -7.52808  -4.19826  -28.93416 1.000 27.63802 ?  6   ARG B N   1 
ATOM   1153 C CA  . ARG B 1 6   ? -8.38791  -3.82566  -30.05519 1.000 28.03684 ?  6   ARG B CA  1 
ATOM   1154 C C   . ARG B 1 6   ? -9.27808  -4.98728  -30.49211 1.000 29.89578 ?  6   ARG B C   1 
ATOM   1155 O O   . ARG B 1 6   ? -10.48460 -4.80003  -30.71427 1.000 25.25613 ?  6   ARG B O   1 
ATOM   1156 C CB  . ARG B 1 6   ? -7.55106  -3.31057  -31.22887 1.000 38.02172 ?  6   ARG B CB  1 
ATOM   1157 C CG  . ARG B 1 6   ? -8.38785  -2.95862  -32.47839 1.000 37.14664 ?  6   ARG B CG  1 
ATOM   1158 C CD  . ARG B 1 6   ? -7.51617  -2.63498  -33.72374 1.000 45.00283 ?  6   ARG B CD  1 
ATOM   1159 N NE  . ARG B 1 6   ? -6.66650  -3.75004  -34.17062 1.000 48.12639 ?  6   ARG B NE  1 
ATOM   1160 C CZ  . ARG B 1 6   ? -7.11144  -4.88899  -34.70863 1.000 48.54096 ?  6   ARG B CZ  1 
ATOM   1161 N NH1 . ARG B 1 6   ? -8.41612  -5.09115  -34.87306 1.000 51.38772 ?  6   ARG B NH1 1 
ATOM   1162 N NH2 . ARG B 1 6   ? -6.24924  -5.83721  -35.07777 1.000 49.11605 ?  6   ARG B NH2 1 
ATOM   1163 N N   . GLU B 1 7   ? -8.71930  -6.20420  -30.62067 1.000 26.51145 ?  7   GLU B N   1 
ATOM   1164 C CA  . GLU B 1 7   ? -9.58963  -7.30969  -31.04574 1.000 30.92465 ?  7   GLU B CA  1 
ATOM   1165 C C   . GLU B 1 7   ? -10.58706 -7.69087  -29.96087 1.000 28.66213 ?  7   GLU B C   1 
ATOM   1166 O O   . GLU B 1 7   ? -11.69648 -8.13913  -30.27494 1.000 24.10991 ?  7   GLU B O   1 
ATOM   1167 C CB  . GLU B 1 7   ? -8.80245  -8.56096  -31.47189 1.000 33.66430 ?  7   GLU B CB  1 
ATOM   1168 C CG  . GLU B 1 7   ? -7.54215  -8.28173  -32.23496 1.000 44.12553 ?  7   GLU B CG  1 
ATOM   1169 C CD  . GLU B 1 7   ? -6.49412  -9.39209  -32.12601 1.000 52.46722 ?  7   GLU B CD  1 
ATOM   1170 O OE1 . GLU B 1 7   ? -6.35455  -10.03297 -31.05407 1.000 56.01341 ?  7   GLU B OE1 1 
ATOM   1171 O OE2 . GLU B 1 7   ? -5.76653  -9.60022  -33.12418 1.000 54.88516 -1 7   GLU B OE2 1 
ATOM   1172 N N   . LEU B 1 8   ? -10.21430 -7.53015  -28.68844 1.000 21.58055 ?  8   LEU B N   1 
ATOM   1173 C CA  . LEU B 1 8   ? -11.17939 -7.73425  -27.61928 1.000 24.38793 ?  8   LEU B CA  1 
ATOM   1174 C C   . LEU B 1 8   ? -12.34349 -6.75743  -27.74112 1.000 22.18835 ?  8   LEU B C   1 
ATOM   1175 O O   . LEU B 1 8   ? -13.50137 -7.14992  -27.58709 1.000 17.79315 ?  8   LEU B O   1 
ATOM   1176 C CB  . LEU B 1 8   ? -10.50369 -7.58807  -26.25345 1.000 24.54192 ?  8   LEU B CB  1 
ATOM   1177 C CG  . LEU B 1 8   ? -9.53052  -8.68236  -25.79895 1.000 29.74226 ?  8   LEU B CG  1 
ATOM   1178 C CD1 . LEU B 1 8   ? -9.03920  -8.33768  -24.38406 1.000 26.73446 ?  8   LEU B CD1 1 
ATOM   1179 C CD2 . LEU B 1 8   ? -10.21848 -10.03577 -25.83795 1.000 29.12151 ?  8   LEU B CD2 1 
ATOM   1180 N N   . VAL B 1 9   ? -12.05498 -5.48165  -28.01485 1.000 20.22244 ?  9   VAL B N   1 
ATOM   1181 C CA  . VAL B 1 9   ? -13.11543 -4.47476  -28.10426 1.000 21.08608 ?  9   VAL B CA  1 
ATOM   1182 C C   . VAL B 1 9   ? -14.06126 -4.79630  -29.26196 1.000 22.88739 ?  9   VAL B C   1 
ATOM   1183 O O   . VAL B 1 9   ? -15.28710 -4.76624  -29.12062 1.000 19.46044 ?  9   VAL B O   1 
ATOM   1184 C CB  . VAL B 1 9   ? -12.50619 -3.06482  -28.24556 1.000 22.41851 ?  9   VAL B CB  1 
ATOM   1185 C CG1 . VAL B 1 9   ? -13.58861 -2.04583  -28.62659 1.000 18.80267 ?  9   VAL B CG1 1 
ATOM   1186 C CG2 . VAL B 1 9   ? -11.82375 -2.64600  -26.96531 1.000 19.62300 ?  9   VAL B CG2 1 
ATOM   1187 N N   . VAL B 1 10  ? -13.49735 -5.12346  -30.42255 1.000 21.22748 ?  10  VAL B N   1 
ATOM   1188 C CA  . VAL B 1 10  ? -14.30236 -5.35356  -31.61901 1.000 22.85062 ?  10  VAL B CA  1 
ATOM   1189 C C   . VAL B 1 10  ? -15.19224 -6.58017  -31.44180 1.000 25.51797 ?  10  VAL B C   1 
ATOM   1190 O O   . VAL B 1 10  ? -16.37811 -6.57226  -31.81927 1.000 22.22187 ?  10  VAL B O   1 
ATOM   1191 C CB  . VAL B 1 10  ? -13.35882 -5.46330  -32.83084 1.000 29.84298 ?  10  VAL B CB  1 
ATOM   1192 C CG1 . VAL B 1 10  ? -14.05435 -6.04886  -34.01230 1.000 39.04529 ?  10  VAL B CG1 1 
ATOM   1193 C CG2 . VAL B 1 10  ? -12.78836 -4.08360  -33.15651 1.000 30.99919 ?  10  VAL B CG2 1 
ATOM   1194 N N   . ASP B 1 11  ? -14.65901 -7.62684  -30.81134 1.000 24.96847 ?  11  ASP B N   1 
ATOM   1195 C CA  . ASP B 1 11  ? -15.45159 -8.82200  -30.53929 1.000 27.46811 ?  11  ASP B CA  1 
ATOM   1196 C C   . ASP B 1 11  ? -16.63459 -8.49392  -29.63868 1.000 24.20044 ?  11  ASP B C   1 
ATOM   1197 O O   . ASP B 1 11  ? -17.76473 -8.92318  -29.89755 1.000 22.02329 ?  11  ASP B O   1 
ATOM   1198 C CB  . ASP B 1 11  ? -14.58170 -9.90146  -29.88847 1.000 23.89119 ?  11  ASP B CB  1 
ATOM   1199 C CG  . ASP B 1 11  ? -15.36774 -11.17685 -29.59071 1.000 31.46587 ?  11  ASP B CG  1 
ATOM   1200 O OD1 . ASP B 1 11  ? -15.44845 -12.03539 -30.50236 1.000 35.78829 -1 11  ASP B OD1 1 
ATOM   1201 O OD2 . ASP B 1 11  ? -15.91525 -11.31422 -28.46345 1.000 30.49136 ?  11  ASP B OD2 1 
ATOM   1202 N N   . PHE B 1 12  ? -16.38480 -7.72962  -28.57107 1.000 19.81433 ?  12  PHE B N   1 
ATOM   1203 C CA  . PHE B 1 12  ? -17.42798 -7.47499  -27.59184 1.000 24.29346 ?  12  PHE B CA  1 
ATOM   1204 C C   . PHE B 1 12  ? -18.52078 -6.58571  -28.17604 1.000 21.06192 ?  12  PHE B C   1 
ATOM   1205 O O   . PHE B 1 12  ? -19.70888 -6.83987  -27.96278 1.000 17.52888 ?  12  PHE B O   1 
ATOM   1206 C CB  . PHE B 1 12  ? -16.82112 -6.85611  -26.33333 1.000 20.25657 ?  12  PHE B CB  1 
ATOM   1207 C CG  . PHE B 1 12  ? -17.82401 -6.64069  -25.22422 1.000 17.36809 ?  12  PHE B CG  1 
ATOM   1208 C CD1 . PHE B 1 12  ? -18.62680 -5.49881  -25.20343 1.000 16.86586 ?  12  PHE B CD1 1 
ATOM   1209 C CD2 . PHE B 1 12  ? -17.95542 -7.55678  -24.20101 1.000 19.74075 ?  12  PHE B CD2 1 
ATOM   1210 C CE1 . PHE B 1 12  ? -19.54525 -5.29281  -24.18107 1.000 21.52499 ?  12  PHE B CE1 1 
ATOM   1211 C CE2 . PHE B 1 12  ? -18.87244 -7.35648  -23.18533 1.000 20.11313 ?  12  PHE B CE2 1 
ATOM   1212 C CZ  . PHE B 1 12  ? -19.66521 -6.22428  -23.17943 1.000 19.79829 ?  12  PHE B CZ  1 
ATOM   1213 N N   . LEU B 1 13  ? -18.13922 -5.54454  -28.92454 1.000 22.06000 ?  13  LEU B N   1 
ATOM   1214 C CA  . LEU B 1 13  ? -19.14693 -4.64849  -29.49918 1.000 22.71986 ?  13  LEU B CA  1 
ATOM   1215 C C   . LEU B 1 13  ? -19.98451 -5.36210  -30.54490 1.000 24.72617 ?  13  LEU B C   1 
ATOM   1216 O O   . LEU B 1 13  ? -21.19390 -5.12143  -30.65188 1.000 22.74116 ?  13  LEU B O   1 
ATOM   1217 C CB  . LEU B 1 13  ? -18.47575 -3.41321  -30.10216 1.000 17.99020 ?  13  LEU B CB  1 
ATOM   1218 C CG  . LEU B 1 13  ? -17.58497 -2.59362  -29.16719 1.000 19.85293 ?  13  LEU B CG  1 
ATOM   1219 C CD1 . LEU B 1 13  ? -17.01652 -1.44905  -29.95521 1.000 16.53317 ?  13  LEU B CD1 1 
ATOM   1220 C CD2 . LEU B 1 13  ? -18.34429 -2.04934  -27.95360 1.000 20.11489 ?  13  LEU B CD2 1 
ATOM   1221 N N   . SER B 1 14  ? -19.36063 -6.23905  -31.33716 1.000 21.24604 ?  14  SER B N   1 
ATOM   1222 C CA  A SER B 1 14  ? -20.11427 -6.98359  -32.33617 0.520 23.40204 ?  14  SER B CA  1 
ATOM   1223 C CA  B SER B 1 14  ? -20.10566 -6.99013  -32.33722 0.480 23.59981 ?  14  SER B CA  1 
ATOM   1224 C C   . SER B 1 14  ? -21.07560 -7.96383  -31.67677 1.000 25.30262 ?  14  SER B C   1 
ATOM   1225 O O   . SER B 1 14  ? -22.21239 -8.12677  -32.13537 1.000 24.27365 ?  14  SER B O   1 
ATOM   1226 C CB  A SER B 1 14  ? -19.16232 -7.72035  -33.27941 0.520 26.63392 ?  14  SER B CB  1 
ATOM   1227 C CB  B SER B 1 14  ? -19.12396 -7.71630  -33.26158 0.480 26.14200 ?  14  SER B CB  1 
ATOM   1228 O OG  A SER B 1 14  ? -18.32441 -6.81227  -33.97450 0.520 29.04122 ?  14  SER B OG  1 
ATOM   1229 O OG  B SER B 1 14  ? -19.63703 -8.93774  -33.75165 0.480 27.19519 ?  14  SER B OG  1 
ATOM   1230 N N   . TYR B 1 15  ? -20.63332 -8.62793  -30.60236 1.000 21.82935 ?  15  TYR B N   1 
ATOM   1231 C CA  . TYR B 1 15  ? -21.51794 -9.49962  -29.83933 1.000 23.61371 ?  15  TYR B CA  1 
ATOM   1232 C C   . TYR B 1 15  ? -22.70410 -8.71950  -29.29755 1.000 22.59795 ?  15  TYR B C   1 
ATOM   1233 O O   . TYR B 1 15  ? -23.85314 -9.14935  -29.41394 1.000 22.27249 ?  15  TYR B O   1 
ATOM   1234 C CB  . TYR B 1 15  ? -20.74050 -10.14886 -28.68928 1.000 20.14227 ?  15  TYR B CB  1 
ATOM   1235 C CG  . TYR B 1 15  ? -21.59371 -10.89715 -27.69335 1.000 22.33432 ?  15  TYR B CG  1 
ATOM   1236 C CD1 . TYR B 1 15  ? -22.16923 -12.12005 -28.03824 1.000 28.90560 ?  15  TYR B CD1 1 
ATOM   1237 C CD2 . TYR B 1 15  ? -21.81534 -10.40577 -26.41328 1.000 21.72308 ?  15  TYR B CD2 1 
ATOM   1238 C CE1 . TYR B 1 15  ? -22.95668 -12.82504 -27.15738 1.000 24.85197 ?  15  TYR B CE1 1 
ATOM   1239 C CE2 . TYR B 1 15  ? -22.61225 -11.10615 -25.50971 1.000 20.80289 ?  15  TYR B CE2 1 
ATOM   1240 C CZ  . TYR B 1 15  ? -23.16743 -12.32275 -25.89311 1.000 26.51952 ?  15  TYR B CZ  1 
ATOM   1241 O OH  . TYR B 1 15  ? -23.95437 -13.05676 -25.02358 1.000 26.60773 ?  15  TYR B OH  1 
ATOM   1242 N N   . LYS B 1 16  ? -22.43757 -7.56812  -28.69017 1.000 21.55948 ?  16  LYS B N   1 
ATOM   1243 C CA  . LYS B 1 16  ? -23.50050 -6.80322  -28.05249 1.000 19.45943 ?  16  LYS B CA  1 
ATOM   1244 C C   . LYS B 1 16  ? -24.51435 -6.27574  -29.06885 1.000 24.05196 ?  16  LYS B C   1 
ATOM   1245 O O   . LYS B 1 16  ? -25.72929 -6.29668  -28.81008 1.000 19.22896 ?  16  LYS B O   1 
ATOM   1246 C CB  . LYS B 1 16  ? -22.89992 -5.64997  -27.25014 1.000 18.94870 ?  16  LYS B CB  1 
ATOM   1247 C CG  . LYS B 1 16  ? -23.93062 -4.97734  -26.38935 1.000 18.86735 ?  16  LYS B CG  1 
ATOM   1248 C CD  . LYS B 1 16  ? -24.58081 -6.00906  -25.45463 1.000 28.45647 ?  16  LYS B CD  1 
ATOM   1249 C CE  . LYS B 1 16  ? -23.52593 -6.76960  -24.62068 1.000 24.91377 ?  16  LYS B CE  1 
ATOM   1250 N NZ  . LYS B 1 16  ? -24.15443 -7.79677  -23.71044 1.000 24.09247 ?  16  LYS B NZ  1 
ATOM   1251 N N   . LEU B 1 17  ? -24.03276 -5.78511  -30.21676 1.000 19.73696 ?  17  LEU B N   1 
ATOM   1252 C CA  . LEU B 1 17  ? -24.93183 -5.28928  -31.25539 1.000 23.36990 ?  17  LEU B CA  1 
ATOM   1253 C C   . LEU B 1 17  ? -25.78898 -6.41610  -31.80233 1.000 22.79308 ?  17  LEU B C   1 
ATOM   1254 O O   . LEU B 1 17  ? -27.00157 -6.26577  -31.95090 1.000 21.14263 ?  17  LEU B O   1 
ATOM   1255 C CB  . LEU B 1 17  ? -24.14090 -4.62577  -32.38540 1.000 20.47928 ?  17  LEU B CB  1 
ATOM   1256 C CG  . LEU B 1 17  ? -23.59948 -3.24516  -32.01102 1.000 22.97823 ?  17  LEU B CG  1 
ATOM   1257 C CD1 . LEU B 1 17  ? -22.43637 -2.85598  -32.90541 1.000 24.14560 ?  17  LEU B CD1 1 
ATOM   1258 C CD2 . LEU B 1 17  ? -24.70005 -2.19671  -32.06587 1.000 18.90885 ?  17  LEU B CD2 1 
ATOM   1259 N N   . SER B 1 18  ? -25.17133 -7.56623  -32.08658 1.000 24.08155 ?  18  SER B N   1 
ATOM   1260 C CA  . SER B 1 18  ? -25.91650 -8.70995  -32.60772 1.000 25.38758 ?  18  SER B CA  1 
ATOM   1261 C C   . SER B 1 18  ? -26.90317 -9.23511  -31.58918 1.000 25.61679 ?  18  SER B C   1 
ATOM   1262 O O   . SER B 1 18  ? -27.97410 -9.74131  -31.95438 1.000 25.40368 ?  18  SER B O   1 
ATOM   1263 C CB  . SER B 1 18  ? -24.95340 -9.82373  -33.01296 1.000 25.51097 ?  18  SER B CB  1 
ATOM   1264 O OG  . SER B 1 18  ? -24.14080 -9.38733  -34.09725 1.000 41.82415 ?  18  SER B OG  1 
ATOM   1265 N N   . GLN B 1 19  ? -26.55332 -9.14597  -30.31437 1.000 23.28305 ?  19  GLN B N   1 
ATOM   1266 C CA  . GLN B 1 19  ? -27.44593 -9.63386  -29.27783 1.000 24.57544 ?  19  GLN B CA  1 
ATOM   1267 C C   . GLN B 1 19  ? -28.70433 -8.78337  -29.20935 1.000 27.97077 ?  19  GLN B C   1 
ATOM   1268 O O   . GLN B 1 19  ? -29.79417 -9.30476  -28.94402 1.000 24.54747 ?  19  GLN B O   1 
ATOM   1269 C CB  . GLN B 1 19  ? -26.69564 -9.64215  -27.94776 1.000 28.19438 ?  19  GLN B CB  1 
ATOM   1270 C CG  . GLN B 1 19  ? -27.45609 -10.13361 -26.75708 1.000 30.06473 ?  19  GLN B CG  1 
ATOM   1271 C CD  . GLN B 1 19  ? -26.67934 -9.89400  -25.48186 1.000 28.63060 ?  19  GLN B CD  1 
ATOM   1272 O OE1 . GLN B 1 19  ? -26.39677 -8.74971  -25.12546 1.000 30.95737 ?  19  GLN B OE1 1 
ATOM   1273 N NE2 . GLN B 1 19  ? -26.31899 -10.96473 -24.79624 1.000 26.86831 ?  19  GLN B NE2 1 
ATOM   1274 N N   . LYS B 1 20  ? -28.58115 -7.48813  -29.48561 1.000 22.68687 ?  20  LYS B N   1 
ATOM   1275 C CA  . LYS B 1 20  ? -29.71017 -6.56474  -29.44636 1.000 25.21242 ?  20  LYS B CA  1 
ATOM   1276 C C   . LYS B 1 20  ? -30.53696 -6.56251  -30.72807 1.000 26.26603 ?  20  LYS B C   1 
ATOM   1277 O O   . LYS B 1 20  ? -31.57190 -5.88021  -30.77450 1.000 28.89432 ?  20  LYS B O   1 
ATOM   1278 C CB  . LYS B 1 20  ? -29.21564 -5.13836  -29.15735 1.000 26.30504 ?  20  LYS B CB  1 
ATOM   1279 C CG  . LYS B 1 20  ? -28.62164 -4.99127  -27.76920 1.000 26.73464 ?  20  LYS B CG  1 
ATOM   1280 C CD  . LYS B 1 20  ? -29.71706 -5.09359  -26.70761 1.000 35.05521 ?  20  LYS B CD  1 
ATOM   1281 C CE  . LYS B 1 20  ? -29.18171 -4.85877  -25.28584 1.000 38.86689 ?  20  LYS B CE  1 
ATOM   1282 N NZ  . LYS B 1 20  ? -29.23630 -6.08068  -24.40560 1.000 36.19075 ?  20  LYS B NZ  1 
ATOM   1283 N N   . GLY B 1 21  ? -30.12849 -7.30200  -31.74951 1.000 21.22782 ?  21  GLY B N   1 
ATOM   1284 C CA  . GLY B 1 21  ? -30.89196 -7.42053  -32.97411 1.000 24.95841 ?  21  GLY B CA  1 
ATOM   1285 C C   . GLY B 1 21  ? -30.28366 -6.74636  -34.18567 1.000 33.82922 ?  21  GLY B C   1 
ATOM   1286 O O   . GLY B 1 21  ? -30.94866 -6.67829  -35.22670 1.000 35.98591 ?  21  GLY B O   1 
ATOM   1287 N N   . TYR B 1 22  ? -29.05511 -6.23000  -34.08251 1.000 24.45480 ?  22  TYR B N   1 
ATOM   1288 C CA  . TYR B 1 22  ? -28.36484 -5.55075  -35.18279 1.000 32.75649 ?  22  TYR B CA  1 
ATOM   1289 C C   . TYR B 1 22  ? -27.20526 -6.43566  -35.62606 1.000 37.15251 ?  22  TYR B C   1 
ATOM   1290 O O   . TYR B 1 22  ? -26.13304 -6.40177  -35.01886 1.000 39.29777 ?  22  TYR B O   1 
ATOM   1291 C CB  . TYR B 1 22  ? -27.84398 -4.17830  -34.75408 1.000 29.43358 ?  22  TYR B CB  1 
ATOM   1292 C CG  . TYR B 1 22  ? -28.90347 -3.16198  -34.37756 1.000 28.83530 ?  22  TYR B CG  1 
ATOM   1293 C CD1 . TYR B 1 22  ? -29.94936 -2.87107  -35.23241 1.000 27.02871 ?  22  TYR B CD1 1 
ATOM   1294 C CD2 . TYR B 1 22  ? -28.82190 -2.46626  -33.17885 1.000 23.88325 ?  22  TYR B CD2 1 
ATOM   1295 C CE1 . TYR B 1 22  ? -30.89112 -1.92906  -34.89601 1.000 28.84371 ?  22  TYR B CE1 1 
ATOM   1296 C CE2 . TYR B 1 22  ? -29.74810 -1.54339  -32.82879 1.000 26.80729 ?  22  TYR B CE2 1 
ATOM   1297 C CZ  . TYR B 1 22  ? -30.78753 -1.26817  -33.68961 1.000 27.03562 ?  22  TYR B CZ  1 
ATOM   1298 O OH  . TYR B 1 22  ? -31.70989 -0.32736  -33.31586 1.000 24.62303 ?  22  TYR B OH  1 
ATOM   1299 N N   . SER B 1 23  ? -27.42191 -7.23738  -36.66887 1.000 40.12860 ?  23  SER B N   1 
ATOM   1300 C CA  . SER B 1 23  ? -26.36047 -8.08257  -37.21058 1.000 47.00430 ?  23  SER B CA  1 
ATOM   1301 C C   . SER B 1 23  ? -25.20465 -7.20727  -37.67239 1.000 45.00421 ?  23  SER B C   1 
ATOM   1302 O O   . SER B 1 23  ? -25.35427 -6.43068  -38.62053 1.000 49.58739 ?  23  SER B O   1 
ATOM   1303 C CB  . SER B 1 23  ? -26.88538 -8.93793  -38.36717 1.000 48.30239 ?  23  SER B CB  1 
ATOM   1304 O OG  . SER B 1 23  ? -27.54067 -8.12701  -39.33549 1.000 47.90025 ?  23  SER B OG  1 
ATOM   1305 N N   . TRP B 1 24  ? -24.05528 -7.29603  -37.00571 1.000 46.18065 ?  24  TRP B N   1 
ATOM   1306 C CA  . TRP B 1 24  ? -22.99012 -6.33125  -37.23867 1.000 43.07089 ?  24  TRP B CA  1 
ATOM   1307 C C   . TRP B 1 24  ? -21.80689 -6.88222  -38.02424 1.000 49.21077 ?  24  TRP B C   1 
ATOM   1308 O O   . TRP B 1 24  ? -21.32939 -6.21720  -38.95164 1.000 52.95291 ?  24  TRP B O   1 
ATOM   1309 C CB  . TRP B 1 24  ? -22.49168 -5.76250  -35.90777 1.000 42.10411 ?  24  TRP B CB  1 
ATOM   1310 C CG  . TRP B 1 24  ? -21.76354 -4.49092  -36.13362 1.000 41.20485 ?  24  TRP B CG  1 
ATOM   1311 C CD1 . TRP B 1 24  ? -20.41278 -4.28179  -36.05044 1.000 34.90483 ?  24  TRP B CD1 1 
ATOM   1312 C CD2 . TRP B 1 24  ? -22.34282 -3.24921  -36.53261 1.000 40.74127 ?  24  TRP B CD2 1 
ATOM   1313 N NE1 . TRP B 1 24  ? -20.12278 -2.97398  -36.35137 1.000 38.60478 ?  24  TRP B NE1 1 
ATOM   1314 C CE2 . TRP B 1 24  ? -21.28966 -2.31889  -36.65716 1.000 38.50650 ?  24  TRP B CE2 1 
ATOM   1315 C CE3 . TRP B 1 24  ? -23.65755 -2.82682  -36.78641 1.000 42.81367 ?  24  TRP B CE3 1 
ATOM   1316 C CZ2 . TRP B 1 24  ? -21.50953 -0.99445  -37.02393 1.000 38.26914 ?  24  TRP B CZ2 1 
ATOM   1317 C CZ3 . TRP B 1 24  ? -23.87303 -1.50976  -37.14992 1.000 37.26515 ?  24  TRP B CZ3 1 
ATOM   1318 C CH2 . TRP B 1 24  ? -22.80764 -0.61033  -37.26454 1.000 38.06856 ?  24  TRP B CH2 1 
ATOM   1319 N N   . SER B 1 25  ? -21.29969 -8.06116  -37.65434 1.000 45.87003 ?  25  SER B N   1 
ATOM   1320 C CA  . SER B 1 25  ? -20.14690 -8.69675  -38.30150 1.000 50.09567 ?  25  SER B CA  1 
ATOM   1321 C C   . SER B 1 25  ? -18.86138 -7.90276  -38.06849 1.000 44.74013 ?  25  SER B C   1 
ATOM   1322 O O   . SER B 1 25  ? -18.82852 -6.68135  -38.24146 1.000 45.43682 ?  25  SER B O   1 
ATOM   1323 C CB  . SER B 1 25  ? -20.38644 -8.88943  -39.80856 1.000 49.16333 ?  25  SER B CB  1 
ATOM   1324 O OG  . SER B 1 25  ? -21.29545 -9.95099  -40.06917 1.000 43.83441 ?  25  SER B OG  1 
ATOM   1325 N N   . GLN B 1 26  ? -17.79498 -8.59613  -37.67830 1.000 48.30175 ?  26  GLN B N   1 
ATOM   1326 C CA  . GLN B 1 26  ? -16.51762 -7.95433  -37.41071 1.000 44.36652 ?  26  GLN B CA  1 
ATOM   1327 C C   . GLN B 1 26  ? -15.86354 -7.47741  -38.71435 1.000 45.75405 ?  26  GLN B C   1 
ATOM   1328 O O   . GLN B 1 26  ? -16.18065 -7.97705  -39.79689 1.000 48.36273 ?  26  GLN B O   1 
ATOM   1329 C CB  . GLN B 1 26  ? -15.61750 -8.92575  -36.64310 1.000 43.79191 ?  26  GLN B CB  1 
ATOM   1330 C CG  . GLN B 1 26  ? -15.86401 -8.83955  -35.12443 1.000 44.39595 ?  26  GLN B CG  1 
ATOM   1331 C CD  . GLN B 1 26  ? -15.82971 -10.17265 -34.39275 1.000 45.58060 ?  26  GLN B CD  1 
ATOM   1332 O OE1 . GLN B 1 26  ? -14.75526 -10.68819 -34.06079 1.000 50.23455 ?  26  GLN B OE1 1 
ATOM   1333 N NE2 . GLN B 1 26  ? -17.01363 -10.73189 -34.12003 1.000 41.34354 ?  26  GLN B NE2 1 
ATOM   1334 N N   . PRO B 1 27  ? -14.95409 -6.48895  -38.62771 1.000 47.15508 ?  82  PRO B N   1 
ATOM   1335 C CA  . PRO B 1 27  ? -14.37351 -5.88616  -39.85505 1.000 44.54017 ?  82  PRO B CA  1 
ATOM   1336 C C   . PRO B 1 27  ? -13.79587 -6.85108  -40.89383 1.000 47.98837 ?  82  PRO B C   1 
ATOM   1337 O O   . PRO B 1 27  ? -14.02354 -6.66236  -42.09832 1.000 47.25922 ?  82  PRO B O   1 
ATOM   1338 C CB  . PRO B 1 27  ? -13.27000 -4.97354  -39.29089 1.000 44.50206 ?  82  PRO B CB  1 
ATOM   1339 C CG  . PRO B 1 27  ? -13.72133 -4.60768  -37.92739 1.000 51.06977 ?  82  PRO B CG  1 
ATOM   1340 C CD  . PRO B 1 27  ? -14.59044 -5.73438  -37.41205 1.000 47.26253 ?  82  PRO B CD  1 
ATOM   1341 N N   . MET B 1 28  ? -13.02212 -7.85477  -40.48193 1.000 39.44554 ?  83  MET B N   1 
ATOM   1342 C CA  . MET B 1 28  ? -12.35899 -8.71303  -41.45281 1.000 41.15966 ?  83  MET B CA  1 
ATOM   1343 C C   . MET B 1 28  ? -13.09914 -10.01002 -41.68507 1.000 37.72524 ?  83  MET B C   1 
ATOM   1344 O O   . MET B 1 28  ? -12.48756 -10.97968 -42.14688 1.000 31.13016 ?  83  MET B O   1 
ATOM   1345 C CB  . MET B 1 28  ? -10.93026 -9.01841  -41.02112 1.000 42.81216 ?  83  MET B CB  1 
ATOM   1346 C CG  . MET B 1 28  ? -9.89888  -8.10226  -41.63434 1.000 47.56682 ?  83  MET B CG  1 
ATOM   1347 S SD  . MET B 1 28  ? -8.35798  -8.43013  -40.81940 1.000 61.32714 ?  83  MET B SD  1 
ATOM   1348 C CE  . MET B 1 28  ? -8.97913  -8.74740  -39.16951 1.000 49.81694 ?  83  MET B CE  1 
ATOM   1349 N N   . ALA B 1 29  ? -14.39685 -10.04623 -41.37459 1.000 31.96867 ?  84  ALA B N   1 
ATOM   1350 C CA  . ALA B 1 29  ? -15.15252 -11.28645 -41.50480 1.000 36.24871 ?  84  ALA B CA  1 
ATOM   1351 C C   . ALA B 1 29  ? -15.28308 -11.70289 -42.96344 1.000 36.39528 ?  84  ALA B C   1 
ATOM   1352 O O   . ALA B 1 29  ? -15.20761 -12.90011 -43.27778 1.000 31.08621 ?  84  ALA B O   1 
ATOM   1353 C CB  . ALA B 1 29  ? -16.52959 -11.13785 -40.85358 1.000 37.77834 ?  84  ALA B CB  1 
ATOM   1354 N N   . ALA B 1 30  ? -15.46534 -10.73095 -43.87176 1.000 26.83638 ?  85  ALA B N   1 
ATOM   1355 C CA  . ALA B 1 30  ? -15.58102 -11.06492 -45.28731 1.000 28.53579 ?  85  ALA B CA  1 
ATOM   1356 C C   . ALA B 1 30  ? -14.22757 -11.46160 -45.89766 1.000 30.14974 ?  85  ALA B C   1 
ATOM   1357 O O   . ALA B 1 30  ? -14.18437 -12.29393 -46.81516 1.000 26.37141 ?  85  ALA B O   1 
ATOM   1358 C CB  . ALA B 1 30  ? -16.20541 -9.89178  -46.05456 1.000 27.64622 ?  85  ALA B CB  1 
ATOM   1359 N N   . VAL B 1 31  ? -13.11995 -10.88439 -45.42204 1.000 27.91151 ?  86  VAL B N   1 
ATOM   1360 C CA  . VAL B 1 31  ? -11.80776 -11.27949 -45.93660 1.000 27.60294 ?  86  VAL B CA  1 
ATOM   1361 C C   . VAL B 1 31  ? -11.48586 -12.70985 -45.51780 1.000 29.05569 ?  86  VAL B C   1 
ATOM   1362 O O   . VAL B 1 31  ? -11.06352 -13.53698 -46.33775 1.000 27.46980 ?  86  VAL B O   1 
ATOM   1363 C CB  . VAL B 1 31  ? -10.71242 -10.30796 -45.46229 1.000 31.36179 ?  86  VAL B CB  1 
ATOM   1364 C CG1 . VAL B 1 31  ? -9.37566  -10.75268 -46.00839 1.000 29.49607 ?  86  VAL B CG1 1 
ATOM   1365 C CG2 . VAL B 1 31  ? -11.01225 -8.88514  -45.92613 1.000 36.55131 ?  86  VAL B CG2 1 
ATOM   1366 N N   . LYS B 1 32  ? -11.66522 -13.00723 -44.22393 1.000 30.40780 ?  87  LYS B N   1 
ATOM   1367 C CA  . LYS B 1 32  ? -11.45218 -14.35839 -43.71253 1.000 30.79598 ?  87  LYS B CA  1 
ATOM   1368 C C   . LYS B 1 32  ? -12.27071 -15.37732 -44.48256 1.000 29.34327 ?  87  LYS B C   1 
ATOM   1369 O O   . LYS B 1 32  ? -11.75502 -16.43953 -44.84345 1.000 26.20348 ?  87  LYS B O   1 
ATOM   1370 C CB  . LYS B 1 32  ? -11.79909 -14.43181 -42.22438 1.000 30.58337 ?  87  LYS B CB  1 
ATOM   1371 C CG  . LYS B 1 32  ? -10.87249 -13.63026 -41.28530 1.000 32.33576 ?  87  LYS B CG  1 
ATOM   1372 C CD  . LYS B 1 32  ? -11.46885 -13.58909 -39.86200 1.000 32.54093 ?  87  LYS B CD  1 
ATOM   1373 C CE  . LYS B 1 32  ? -10.51107 -12.99374 -38.82684 1.000 34.71488 ?  87  LYS B CE  1 
ATOM   1374 N NZ  . LYS B 1 32  ? -11.01862 -13.25794 -37.42616 1.000 34.58880 ?  87  LYS B NZ  1 
ATOM   1375 N N   . GLN B 1 33  ? -13.55167 -15.07443 -44.74888 1.000 26.43382 ?  88  GLN B N   1 
ATOM   1376 C CA  . GLN B 1 33  ? -14.40577 -16.03884 -45.43379 1.000 26.34468 ?  88  GLN B CA  1 
ATOM   1377 C C   . GLN B 1 33  ? -13.95594 -16.25730 -46.87104 1.000 26.25046 ?  88  GLN B C   1 
ATOM   1378 O O   . GLN B 1 33  ? -13.85221 -17.40113 -47.33091 1.000 24.82980 ?  88  GLN B O   1 
ATOM   1379 C CB  . GLN B 1 33  ? -15.87106 -15.58242 -45.38799 1.000 34.93067 ?  88  GLN B CB  1 
ATOM   1380 C CG  . GLN B 1 33  ? -16.83648 -16.66960 -45.80954 1.000 35.55107 ?  88  GLN B CG  1 
ATOM   1381 C CD  . GLN B 1 33  ? -16.54571 -18.00003 -45.11389 1.000 47.06982 ?  88  GLN B CD  1 
ATOM   1382 O OE1 . GLN B 1 33  ? -16.37633 -18.05357 -43.88997 1.000 50.77953 ?  88  GLN B OE1 1 
ATOM   1383 N NE2 . GLN B 1 33  ? -16.46428 -19.07625 -45.89593 1.000 43.22516 ?  88  GLN B NE2 1 
ATOM   1384 N N   . ALA B 1 34  ? -13.67451 -15.16979 -47.59689 1.000 22.74643 ?  89  ALA B N   1 
ATOM   1385 C CA  . ALA B 1 34  ? -13.16615 -15.29149 -48.96163 1.000 24.56250 ?  89  ALA B CA  1 
ATOM   1386 C C   . ALA B 1 34  ? -11.84786 -16.07907 -49.01179 1.000 25.57113 ?  89  ALA B C   1 
ATOM   1387 O O   . ALA B 1 34  ? -11.63157 -16.88245 -49.92692 1.000 23.07334 ?  89  ALA B O   1 
ATOM   1388 C CB  . ALA B 1 34  ? -12.98491 -13.89570 -49.57329 1.000 21.71301 ?  89  ALA B CB  1 
ATOM   1389 N N   . LEU B 1 35  ? -10.94894 -15.85744 -48.04460 1.000 23.87207 ?  90  LEU B N   1 
ATOM   1390 C CA  . LEU B 1 35  ? -9.65846  -16.55510 -48.05261 1.000 21.96067 ?  90  LEU B CA  1 
ATOM   1391 C C   . LEU B 1 35  ? -9.83013  -18.04895 -47.78696 1.000 21.87093 ?  90  LEU B C   1 
ATOM   1392 O O   . LEU B 1 35  ? -9.22514  -18.88651 -48.47113 1.000 20.75378 ?  90  LEU B O   1 
ATOM   1393 C CB  . LEU B 1 35  ? -8.72049  -15.94183 -47.01469 1.000 22.89886 ?  90  LEU B CB  1 
ATOM   1394 C CG  . LEU B 1 35  ? -7.23376  -16.26348 -47.20323 1.000 28.11459 ?  90  LEU B CG  1 
ATOM   1395 C CD1 . LEU B 1 35  ? -6.77417  -16.02275 -48.62774 1.000 24.35110 ?  90  LEU B CD1 1 
ATOM   1396 C CD2 . LEU B 1 35  ? -6.42271  -15.40921 -46.24395 1.000 26.93659 ?  90  LEU B CD2 1 
ATOM   1397 N N   . ARG B 1 36  ? -10.63495 -18.39446 -46.77885 1.000 19.90934 ?  91  ARG B N   1 
ATOM   1398 C CA  . ARG B 1 36  ? -10.92845 -19.79942 -46.49206 1.000 25.89506 ?  91  ARG B CA  1 
ATOM   1399 C C   . ARG B 1 36  ? -11.48788 -20.49472 -47.72167 1.000 26.63852 ?  91  ARG B C   1 
ATOM   1400 O O   . ARG B 1 36  ? -11.11563 -21.63282 -48.03747 1.000 25.97814 ?  91  ARG B O   1 
ATOM   1401 C CB  . ARG B 1 36  ? -11.94365 -19.91144 -45.35268 1.000 27.92579 ?  91  ARG B CB  1 
ATOM   1402 C CG  . ARG B 1 36  ? -11.46815 -19.52318 -43.97157 1.000 31.26293 ?  91  ARG B CG  1 
ATOM   1403 C CD  . ARG B 1 36  ? -12.63332 -19.67732 -42.98765 1.000 32.70172 ?  91  ARG B CD  1 
ATOM   1404 N NE  . ARG B 1 36  ? -12.18880 -19.59680 -41.59816 1.000 39.88385 ?  91  ARG B NE  1 
ATOM   1405 C CZ  . ARG B 1 36  ? -12.92312 -19.96335 -40.54849 1.000 40.02843 ?  91  ARG B CZ  1 
ATOM   1406 N NH1 . ARG B 1 36  ? -14.14792 -20.44765 -40.72514 1.000 44.56417 ?  91  ARG B NH1 1 
ATOM   1407 N NH2 . ARG B 1 36  ? -12.42768 -19.85537 -39.31882 1.000 40.50692 ?  91  ARG B NH2 1 
ATOM   1408 N N   . GLU B 1 37  ? -12.41273 -19.82574 -48.41388 1.000 24.38754 ?  92  GLU B N   1 
ATOM   1409 C CA  . GLU B 1 37  ? -13.05326 -20.40859 -49.58623 1.000 30.84728 ?  92  GLU B CA  1 
ATOM   1410 C C   . GLU B 1 37  ? -12.04983 -20.63160 -50.70719 1.000 27.07342 ?  92  GLU B C   1 
ATOM   1411 O O   . GLU B 1 37  ? -12.02084 -21.70087 -51.33066 1.000 26.21114 ?  92  GLU B O   1 
ATOM   1412 C CB  . GLU B 1 37  ? -14.19807 -19.50117 -50.04955 1.000 34.86886 ?  92  GLU B CB  1 
ATOM   1413 C CG  . GLU B 1 37  ? -14.94628 -20.04246 -51.26781 1.000 39.35816 ?  92  GLU B CG  1 
ATOM   1414 C CD  . GLU B 1 37  ? -15.33307 -21.51702 -51.11653 1.000 46.98564 ?  92  GLU B CD  1 
ATOM   1415 O OE1 . GLU B 1 37  ? -15.18620 -22.28320 -52.10352 1.000 48.77924 ?  92  GLU B OE1 1 
ATOM   1416 O OE2 . GLU B 1 37  ? -15.82612 -21.90232 -50.02825 1.000 52.49112 -1 92  GLU B OE2 1 
ATOM   1417 N N   . ALA B 1 38  ? -11.22097 -19.62573 -50.98431 1.000 27.23918 ?  93  ALA B N   1 
ATOM   1418 C CA  . ALA B 1 38  ? -10.23778 -19.76118 -52.05346 1.000 25.44866 ?  93  ALA B CA  1 
ATOM   1419 C C   . ALA B 1 38  ? -9.20625  -20.82945 -51.71958 1.000 23.13609 ?  93  ALA B C   1 
ATOM   1420 O O   . ALA B 1 38  ? -8.75337  -21.55290 -52.61092 1.000 23.76353 ?  93  ALA B O   1 
ATOM   1421 C CB  . ALA B 1 38  ? -9.55924  -18.41481 -52.31341 1.000 27.25943 ?  93  ALA B CB  1 
ATOM   1422 N N   . GLY B 1 39  ? -8.83184  -20.93985 -50.44376 1.000 23.39220 ?  94  GLY B N   1 
ATOM   1423 C CA  . GLY B 1 39  ? -7.86134  -21.94671 -50.05380 1.000 24.13443 ?  94  GLY B CA  1 
ATOM   1424 C C   . GLY B 1 39  ? -8.41948  -23.35161 -50.16350 1.000 24.28045 ?  94  GLY B C   1 
ATOM   1425 O O   . GLY B 1 39  ? -7.71275  -24.27184 -50.57504 1.000 25.21471 ?  94  GLY B O   1 
ATOM   1426 N N   . ASP B 1 40  ? -9.68508  -23.54064 -49.77930 1.000 25.43629 ?  95  ASP B N   1 
ATOM   1427 C CA  . ASP B 1 40  ? -10.35274 -24.82414 -50.00250 1.000 25.33664 ?  95  ASP B CA  1 
ATOM   1428 C C   . ASP B 1 40  ? -10.37576 -25.17559 -51.48751 1.000 25.29441 ?  95  ASP B C   1 
ATOM   1429 O O   . ASP B 1 40  ? -10.07156 -26.31061 -51.87456 1.000 27.14727 ?  95  ASP B O   1 
ATOM   1430 C CB  . ASP B 1 40  ? -11.77377 -24.78652 -49.44285 1.000 26.34828 ?  95  ASP B CB  1 
ATOM   1431 C CG  . ASP B 1 40  ? -11.82598 -24.92870 -47.92501 1.000 31.00873 ?  95  ASP B CG  1 
ATOM   1432 O OD1 . ASP B 1 40  ? -10.80227 -25.31839 -47.31401 1.000 32.23820 ?  95  ASP B OD1 1 
ATOM   1433 O OD2 . ASP B 1 40  ? -12.90727 -24.63685 -47.33782 1.000 28.92662 -1 95  ASP B OD2 1 
ATOM   1434 N N   . GLU B 1 41  ? -10.71899 -24.20612 -52.34177 1.000 25.39630 ?  96  GLU B N   1 
ATOM   1435 C CA  . GLU B 1 41  ? -10.77555 -24.47991 -53.77659 1.000 27.73497 ?  96  GLU B CA  1 
ATOM   1436 C C   . GLU B 1 41  ? -9.40206  -24.81064 -54.33792 1.000 28.48756 ?  96  GLU B C   1 
ATOM   1437 O O   . GLU B 1 41  ? -9.26894  -25.73436 -55.15051 1.000 26.60934 ?  96  GLU B O   1 
ATOM   1438 C CB  . GLU B 1 41  ? -11.38600 -23.29783 -54.53343 1.000 31.03816 ?  96  GLU B CB  1 
ATOM   1439 C CG  . GLU B 1 41  ? -12.85450 -23.10370 -54.20853 1.000 34.38997 ?  96  GLU B CG  1 
ATOM   1440 C CD  . GLU B 1 41  ? -13.47127 -21.88323 -54.88511 1.000 38.90801 ?  96  GLU B CD  1 
ATOM   1441 O OE1 . GLU B 1 41  ? -13.05445 -21.53362 -56.01727 1.000 37.29441 ?  96  GLU B OE1 1 
ATOM   1442 O OE2 . GLU B 1 41  ? -14.39142 -21.28781 -54.28148 1.000 43.73193 -1 96  GLU B OE2 1 
ATOM   1443 N N   . PHE B 1 42  ? -8.37013  -24.06721 -53.91836 1.000 20.71097 ?  97  PHE B N   1 
ATOM   1444 C CA  . PHE B 1 42  ? -7.01800  -24.32153 -54.40788 1.000 27.07509 ?  97  PHE B CA  1 
ATOM   1445 C C   . PHE B 1 42  ? -6.55618  -25.72517 -54.03396 1.000 26.22665 ?  97  PHE B C   1 
ATOM   1446 O O   . PHE B 1 42  ? -6.00493  -26.45465 -54.86429 1.000 28.18179 ?  97  PHE B O   1 
ATOM   1447 C CB  . PHE B 1 42  ? -6.04476  -23.28797 -53.84580 1.000 22.95661 ?  97  PHE B CB  1 
ATOM   1448 C CG  . PHE B 1 42  ? -4.60210  -23.58668 -54.15932 1.000 26.18502 ?  97  PHE B CG  1 
ATOM   1449 C CD1 . PHE B 1 42  ? -4.16124  -23.65368 -55.47483 1.000 21.97579 ?  97  PHE B CD1 1 
ATOM   1450 C CD2 . PHE B 1 42  ? -3.68515  -23.79614 -53.14646 1.000 26.26226 ?  97  PHE B CD2 1 
ATOM   1451 C CE1 . PHE B 1 42  ? -2.84731  -23.91340 -55.77514 1.000 23.00301 ?  97  PHE B CE1 1 
ATOM   1452 C CE2 . PHE B 1 42  ? -2.37033  -24.04737 -53.44035 1.000 23.88745 ?  97  PHE B CE2 1 
ATOM   1453 C CZ  . PHE B 1 42  ? -1.94865  -24.10540 -54.76108 1.000 27.31290 ?  97  PHE B CZ  1 
ATOM   1454 N N   . GLU B 1 43  ? -6.76979  -26.11789 -52.77680 1.000 25.73902 ?  98  GLU B N   1 
ATOM   1455 C CA  . GLU B 1 43  ? -6.30557  -27.42378 -52.32615 1.000 25.14554 ?  98  GLU B CA  1 
ATOM   1456 C C   . GLU B 1 43  ? -7.08485  -28.55329 -52.98579 1.000 29.72975 ?  98  GLU B C   1 
ATOM   1457 O O   . GLU B 1 43  ? -6.52326  -29.62069 -53.24127 1.000 30.51259 ?  98  GLU B O   1 
ATOM   1458 C CB  . GLU B 1 43  ? -6.40607  -27.51424 -50.80626 1.000 28.93644 ?  98  GLU B CB  1 
ATOM   1459 C CG  . GLU B 1 43  ? -5.38880  -26.61765 -50.07783 1.000 28.05120 ?  98  GLU B CG  1 
ATOM   1460 C CD  . GLU B 1 43  ? -5.88352  -26.15645 -48.70888 1.000 33.37172 ?  98  GLU B CD  1 
ATOM   1461 O OE1 . GLU B 1 43  ? -6.78581  -26.81230 -48.11928 1.000 32.51916 ?  98  GLU B OE1 1 
ATOM   1462 O OE2 . GLU B 1 43  ? -5.39582  -25.11184 -48.23159 1.000 33.82782 -1 98  GLU B OE2 1 
ATOM   1463 N N   . LEU B 1 44  ? -8.36278  -28.32963 -53.29277 1.000 28.63286 ?  99  LEU B N   1 
ATOM   1464 C CA  . LEU B 1 44  ? -9.17365  -29.38100 -53.89599 1.000 32.25151 ?  99  LEU B CA  1 
ATOM   1465 C C   . LEU B 1 44  ? -8.93206  -29.48951 -55.40011 1.000 34.00429 ?  99  LEU B C   1 
ATOM   1466 O O   . LEU B 1 44  ? -8.71361  -30.58986 -55.91868 1.000 36.57488 ?  99  LEU B O   1 
ATOM   1467 C CB  . LEU B 1 44  ? -10.65126 -29.13073 -53.60157 1.000 28.82394 ?  99  LEU B CB  1 
ATOM   1468 C CG  . LEU B 1 44  ? -11.55963 -30.27258 -54.03614 1.000 39.23528 ?  99  LEU B CG  1 
ATOM   1469 C CD1 . LEU B 1 44  ? -11.71795 -31.26934 -52.89924 1.000 37.88142 ?  99  LEU B CD1 1 
ATOM   1470 C CD2 . LEU B 1 44  ? -12.90393 -29.73484 -54.47720 1.000 36.03611 ?  99  LEU B CD2 1 
ATOM   1471 N N   . ARG B 1 45  ? -8.95724  -28.36198 -56.11900 1.000 32.60022 ?  100 ARG B N   1 
ATOM   1472 C CA  . ARG B 1 45  ? -8.95705  -28.38695 -57.57950 1.000 35.70014 ?  100 ARG B CA  1 
ATOM   1473 C C   . ARG B 1 45  ? -7.57224  -28.28284 -58.20300 1.000 33.54636 ?  100 ARG B C   1 
ATOM   1474 O O   . ARG B 1 45  ? -7.44413  -28.50059 -59.41416 1.000 32.47851 ?  100 ARG B O   1 
ATOM   1475 C CB  . ARG B 1 45  ? -9.82975  -27.25569 -58.12611 1.000 36.79377 ?  100 ARG B CB  1 
ATOM   1476 C CG  . ARG B 1 45  ? -11.28479 -27.34080 -57.69365 1.000 38.20259 ?  100 ARG B CG  1 
ATOM   1477 C CD  . ARG B 1 45  ? -12.19182 -26.55033 -58.64080 1.000 44.80665 ?  100 ARG B CD  1 
ATOM   1478 N NE  . ARG B 1 45  ? -11.95959 -25.10770 -58.53917 1.000 53.01412 ?  100 ARG B NE  1 
ATOM   1479 C CZ  . ARG B 1 45  ? -12.84153 -24.24060 -58.04288 1.000 47.96890 ?  100 ARG B CZ  1 
ATOM   1480 N NH1 . ARG B 1 45  ? -12.54425 -22.94508 -57.98372 1.000 36.60774 ?  100 ARG B NH1 1 
ATOM   1481 N NH2 . ARG B 1 45  ? -14.02618 -24.67329 -57.60874 1.000 47.38377 ?  100 ARG B NH2 1 
ATOM   1482 N N   . TYR B 1 46  ? -6.54161  -27.93661 -57.43067 1.000 35.90172 ?  101 TYR B N   1 
ATOM   1483 C CA  . TYR B 1 46  ? -5.18415  -27.76270 -57.95175 1.000 31.25679 ?  101 TYR B CA  1 
ATOM   1484 C C   . TYR B 1 46  ? -4.18913  -28.53861 -57.10183 1.000 33.69623 ?  101 TYR B C   1 
ATOM   1485 O O   . TYR B 1 46  ? -3.13978  -28.03079 -56.70975 1.000 30.78079 ?  101 TYR B O   1 
ATOM   1486 C CB  . TYR B 1 46  ? -4.81772  -26.28206 -58.02240 1.000 29.64111 ?  101 TYR B CB  1 
ATOM   1487 C CG  . TYR B 1 46  ? -5.67821  -25.55098 -59.00259 1.000 32.84273 ?  101 TYR B CG  1 
ATOM   1488 C CD1 . TYR B 1 46  ? -5.30216  -25.45593 -60.32810 1.000 29.48709 ?  101 TYR B CD1 1 
ATOM   1489 C CD2 . TYR B 1 46  ? -6.90703  -25.00269 -58.61608 1.000 29.15489 ?  101 TYR B CD2 1 
ATOM   1490 C CE1 . TYR B 1 46  ? -6.09854  -24.82095 -61.23575 1.000 32.88341 ?  101 TYR B CE1 1 
ATOM   1491 C CE2 . TYR B 1 46  ? -7.71440  -24.36684 -59.52196 1.000 32.85786 ?  101 TYR B CE2 1 
ATOM   1492 C CZ  . TYR B 1 46  ? -7.30731  -24.27687 -60.83243 1.000 34.45528 ?  101 TYR B CZ  1 
ATOM   1493 O OH  . TYR B 1 46  ? -8.10256  -23.64278 -61.75125 1.000 38.69160 ?  101 TYR B OH  1 
ATOM   1494 N N   . ARG B 1 47  ? -4.49706  -29.81556 -56.85054 1.000 40.78150 ?  102 ARG B N   1 
ATOM   1495 C CA  . ARG B 1 47  ? -3.69848  -30.61683 -55.92470 1.000 40.56810 ?  102 ARG B CA  1 
ATOM   1496 C C   . ARG B 1 47  ? -2.25856  -30.74610 -56.38371 1.000 38.77765 ?  102 ARG B C   1 
ATOM   1497 O O   . ARG B 1 47  ? -1.33804  -30.74827 -55.55728 1.000 39.07315 ?  102 ARG B O   1 
ATOM   1498 C CB  . ARG B 1 47  ? -4.31737  -32.00281 -55.75657 1.000 46.23466 ?  102 ARG B CB  1 
ATOM   1499 C CG  . ARG B 1 47  ? -5.50870  -32.05120 -54.79068 1.000 50.05864 ?  102 ARG B CG  1 
ATOM   1500 C CD  . ARG B 1 47  ? -5.84404  -33.49837 -54.41010 1.000 57.64886 ?  102 ARG B CD  1 
ATOM   1501 N NE  . ARG B 1 47  ? -4.72122  -34.40810 -54.63841 1.000 62.86780 ?  102 ARG B NE  1 
ATOM   1502 C CZ  . ARG B 1 47  ? -3.72644  -34.62737 -53.77777 1.000 62.05962 ?  102 ARG B CZ  1 
ATOM   1503 N NH1 . ARG B 1 47  ? -3.71571  -34.03831 -52.58182 1.000 67.23022 ?  102 ARG B NH1 1 
ATOM   1504 N NH2 . ARG B 1 47  ? -2.75383  -35.47711 -54.10214 1.000 63.76034 ?  102 ARG B NH2 1 
ATOM   1505 N N   . ARG B 1 48  ? -2.03616  -30.85852 -57.69353 1.000 39.95485 ?  103 ARG B N   1 
ATOM   1506 C CA  . ARG B 1 48  ? -0.66630  -30.92223 -58.19045 1.000 37.02981 ?  103 ARG B CA  1 
ATOM   1507 C C   . ARG B 1 48  ? 0.12346   -29.68858 -57.78070 1.000 37.13435 ?  103 ARG B C   1 
ATOM   1508 O O   . ARG B 1 48  ? 1.26365   -29.79906 -57.31277 1.000 36.73847 ?  103 ARG B O   1 
ATOM   1509 C CB  . ARG B 1 48  ? -0.67336  -31.07017 -59.70887 1.000 44.31153 ?  103 ARG B CB  1 
ATOM   1510 C CG  . ARG B 1 48  ? 0.67748   -31.28016 -60.36445 1.000 45.08950 ?  103 ARG B CG  1 
ATOM   1511 C CD  . ARG B 1 48  ? 0.54668   -31.97965 -61.74179 1.000 48.64934 ?  103 ARG B CD  1 
ATOM   1512 N NE  . ARG B 1 48  ? -0.80085  -31.90583 -62.32383 1.000 56.86105 ?  103 ARG B NE  1 
ATOM   1513 C CZ  . ARG B 1 48  ? -1.73949  -32.84301 -62.17136 1.000 56.08538 ?  103 ARG B CZ  1 
ATOM   1514 N NH1 . ARG B 1 48  ? -1.48952  -33.91688 -61.43393 1.000 55.47999 ?  103 ARG B NH1 1 
ATOM   1515 N NH2 . ARG B 1 48  ? -2.93620  -32.69918 -62.73057 1.000 59.34015 ?  103 ARG B NH2 1 
ATOM   1516 N N   . ALA B 1 49  ? -0.46308  -28.49871 -57.95427 1.000 37.43421 ?  104 ALA B N   1 
ATOM   1517 C CA  . ALA B 1 49  ? 0.24470   -27.27707 -57.58353 1.000 33.89672 ?  104 ALA B CA  1 
ATOM   1518 C C   . ALA B 1 49  ? 0.40895   -27.16941 -56.06938 1.000 31.62758 ?  104 ALA B C   1 
ATOM   1519 O O   . ALA B 1 49  ? 1.43767   -26.68624 -55.57796 1.000 31.70825 ?  104 ALA B O   1 
ATOM   1520 C CB  . ALA B 1 49  ? -0.50059  -26.06295 -58.13241 1.000 32.66798 ?  104 ALA B CB  1 
ATOM   1521 N N   . PHE B 1 50  ? -0.61669  -27.58367 -55.32267 1.000 31.78449 ?  105 PHE B N   1 
ATOM   1522 C CA  . PHE B 1 50  ? -0.56003  -27.57592 -53.86709 1.000 28.97090 ?  105 PHE B CA  1 
ATOM   1523 C C   . PHE B 1 50  ? 0.57234   -28.46302 -53.36438 1.000 35.63638 ?  105 PHE B C   1 
ATOM   1524 O O   . PHE B 1 50  ? 1.40060   -28.03328 -52.55325 1.000 34.50546 ?  105 PHE B O   1 
ATOM   1525 C CB  . PHE B 1 50  ? -1.92330  -28.02825 -53.32633 1.000 31.65597 ?  105 PHE B CB  1 
ATOM   1526 C CG  . PHE B 1 50  ? -2.02954  -28.06965 -51.82260 1.000 29.72562 ?  105 PHE B CG  1 
ATOM   1527 C CD1 . PHE B 1 50  ? -1.45993  -27.08663 -51.03076 1.000 31.91479 ?  105 PHE B CD1 1 
ATOM   1528 C CD2 . PHE B 1 50  ? -2.75539  -29.07543 -51.20439 1.000 33.14981 ?  105 PHE B CD2 1 
ATOM   1529 C CE1 . PHE B 1 50  ? -1.57038  -27.13047 -49.64452 1.000 25.33696 ?  105 PHE B CE1 1 
ATOM   1530 C CE2 . PHE B 1 50  ? -2.88661  -29.11146 -49.82561 1.000 35.66834 ?  105 PHE B CE2 1 
ATOM   1531 C CZ  . PHE B 1 50  ? -2.29042  -28.12568 -49.04517 1.000 28.45556 ?  105 PHE B CZ  1 
ATOM   1532 N N   . SER B 1 51  ? 0.64214   -29.70276 -53.86717 1.000 36.47398 ?  106 SER B N   1 
ATOM   1533 C CA  . SER B 1 51  ? 1.63460   -30.66816 -53.38778 1.000 36.09820 ?  106 SER B CA  1 
ATOM   1534 C C   . SER B 1 51  ? 3.03840   -30.29979 -53.83838 1.000 32.04263 ?  106 SER B C   1 
ATOM   1535 O O   . SER B 1 51  ? 4.01395   -30.52578 -53.11086 1.000 37.88344 ?  106 SER B O   1 
ATOM   1536 C CB  . SER B 1 51  ? 1.27744   -32.07369 -53.87750 1.000 40.69236 ?  106 SER B CB  1 
ATOM   1537 O OG  . SER B 1 51  ? -0.08120  -32.36951 -53.59091 1.000 43.89576 ?  106 SER B OG  1 
ATOM   1538 N N   . ASP B 1 52  ? 3.16846   -29.74849 -55.03926 1.000 32.50437 ?  107 ASP B N   1 
ATOM   1539 C CA  . ASP B 1 52  ? 4.46114   -29.23201 -55.45097 1.000 35.87078 ?  107 ASP B CA  1 
ATOM   1540 C C   . ASP B 1 52  ? 4.98856   -28.21366 -54.45430 1.000 38.78225 ?  107 ASP B C   1 
ATOM   1541 O O   . ASP B 1 52  ? 6.17255   -28.22548 -54.10888 1.000 34.26536 ?  107 ASP B O   1 
ATOM   1542 C CB  . ASP B 1 52  ? 4.37427   -28.59126 -56.82629 1.000 41.22357 ?  107 ASP B CB  1 
ATOM   1543 C CG  . ASP B 1 52  ? 5.73917   -28.31212 -57.39157 1.000 43.71885 ?  107 ASP B CG  1 
ATOM   1544 O OD1 . ASP B 1 52  ? 6.43851   -29.30779 -57.67502 1.000 47.62833 ?  107 ASP B OD1 1 
ATOM   1545 O OD2 . ASP B 1 52  ? 6.12562   -27.12579 -57.51580 1.000 46.10308 -1 107 ASP B OD2 1 
ATOM   1546 N N   . LEU B 1 53  ? 4.12926   -27.30744 -53.98989 1.000 35.38968 ?  108 LEU B N   1 
ATOM   1547 C CA  . LEU B 1 53  ? 4.61217   -26.29978 -53.05426 1.000 36.18748 ?  108 LEU B CA  1 
ATOM   1548 C C   . LEU B 1 53  ? 4.91760   -26.90749 -51.68672 1.000 34.23578 ?  108 LEU B C   1 
ATOM   1549 O O   . LEU B 1 53  ? 5.96109   -26.61007 -51.09490 1.000 34.70074 ?  108 LEU B O   1 
ATOM   1550 C CB  . LEU B 1 53  ? 3.59147   -25.16815 -52.95088 1.000 35.97527 ?  108 LEU B CB  1 
ATOM   1551 C CG  . LEU B 1 53  ? 4.01485   -23.81234 -52.39663 1.000 36.79232 ?  108 LEU B CG  1 
ATOM   1552 C CD1 . LEU B 1 53  ? 5.18514   -23.25582 -53.17891 1.000 36.64225 ?  108 LEU B CD1 1 
ATOM   1553 C CD2 . LEU B 1 53  ? 2.81845   -22.87098 -52.46961 1.000 33.39177 ?  108 LEU B CD2 1 
ATOM   1554 N N   . THR B 1 54  ? 4.03844   -27.78078 -51.17505 1.000 32.29815 ?  109 THR B N   1 
ATOM   1555 C CA  . THR B 1 54  ? 4.27108   -28.34929 -49.84742 1.000 31.07273 ?  109 THR B CA  1 
ATOM   1556 C C   . THR B 1 54  ? 5.48137   -29.27660 -49.82110 1.000 37.91305 ?  109 THR B C   1 
ATOM   1557 O O   . THR B 1 54  ? 6.16380   -29.37214 -48.79361 1.000 37.66516 ?  109 THR B O   1 
ATOM   1558 C CB  . THR B 1 54  ? 3.02598   -29.09440 -49.35171 1.000 33.21700 ?  109 THR B CB  1 
ATOM   1559 O OG1 . THR B 1 54  ? 2.77587   -30.23864 -50.17919 1.000 41.18836 ?  109 THR B OG1 1 
ATOM   1560 C CG2 . THR B 1 54  ? 1.81337   -28.19023 -49.39839 1.000 33.28324 ?  109 THR B CG2 1 
ATOM   1561 N N   . SER B 1 55  ? 5.77504   -29.95341 -50.92898 1.000 34.00282 ?  110 SER B N   1 
ATOM   1562 C CA  . SER B 1 55  ? 6.90692   -30.86655 -50.93923 1.000 38.53676 ?  110 SER B CA  1 
ATOM   1563 C C   . SER B 1 55  ? 8.25398   -30.15731 -50.84011 1.000 40.85703 ?  110 SER B C   1 
ATOM   1564 O O   . SER B 1 55  ? 9.28037   -30.83790 -50.80314 1.000 41.36322 ?  110 SER B O   1 
ATOM   1565 C CB  . SER B 1 55  ? 6.87535   -31.71335 -52.20643 1.000 37.68393 ?  110 SER B CB  1 
ATOM   1566 O OG  . SER B 1 55  ? 7.45118   -30.97921 -53.27126 1.000 41.08616 ?  110 SER B OG  1 
ATOM   1567 N N   . GLN B 1 56  ? 8.29145   -28.82824 -50.77597 1.000 38.22055 ?  111 GLN B N   1 
ATOM   1568 C CA  . GLN B 1 56  ? 9.54904   -28.10315 -50.85385 1.000 37.58629 ?  111 GLN B CA  1 
ATOM   1569 C C   . GLN B 1 56  ? 10.14369  -27.77004 -49.50029 1.000 37.47024 ?  111 GLN B C   1 
ATOM   1570 O O   . GLN B 1 56  ? 11.25283  -27.22812 -49.45147 1.000 40.62903 ?  111 GLN B O   1 
ATOM   1571 C CB  . GLN B 1 56  ? 9.37057   -26.81365 -51.64415 1.000 37.50766 ?  111 GLN B CB  1 
ATOM   1572 C CG  . GLN B 1 56  ? 8.98711   -27.03768 -53.06975 1.000 39.92773 ?  111 GLN B CG  1 
ATOM   1573 C CD  . GLN B 1 56  ? 8.76895   -25.74136 -53.76606 1.000 40.70571 ?  111 GLN B CD  1 
ATOM   1574 O OE1 . GLN B 1 56  ? 9.53198   -24.78671 -53.57095 1.000 43.23584 ?  111 GLN B OE1 1 
ATOM   1575 N NE2 . GLN B 1 56  ? 7.72169   -25.67465 -54.58303 1.000 46.23346 ?  111 GLN B NE2 1 
ATOM   1576 N N   . LEU B 1 57  ? 9.44427   -28.07086 -48.40958 1.000 35.00999 ?  112 LEU B N   1 
ATOM   1577 C CA  . LEU B 1 57  ? 9.94533   -27.74490 -47.08398 1.000 38.30704 ?  112 LEU B CA  1 
ATOM   1578 C C   . LEU B 1 57  ? 9.29620   -28.66484 -46.06799 1.000 37.49208 ?  112 LEU B C   1 
ATOM   1579 O O   . LEU B 1 57  ? 8.08684   -28.89823 -46.11506 1.000 37.75746 ?  112 LEU B O   1 
ATOM   1580 C CB  . LEU B 1 57  ? 9.65144   -26.28256 -46.71498 1.000 36.43757 ?  112 LEU B CB  1 
ATOM   1581 C CG  . LEU B 1 57  ? 10.05172  -25.82989 -45.31354 1.000 35.18939 ?  112 LEU B CG  1 
ATOM   1582 C CD1 . LEU B 1 57  ? 11.54010  -25.53022 -45.29812 1.000 36.85629 ?  112 LEU B CD1 1 
ATOM   1583 C CD2 . LEU B 1 57  ? 9.25536   -24.60512 -44.87742 1.000 33.71844 ?  112 LEU B CD2 1 
ATOM   1584 N N   . HIS B 1 58  ? 10.09915  -29.15821 -45.13661 1.000 43.94929 ?  113 HIS B N   1 
ATOM   1585 C CA  . HIS B 1 58  ? 9.57467   -29.88617 -43.99487 1.000 46.42829 ?  113 HIS B CA  1 
ATOM   1586 C C   . HIS B 1 58  ? 10.19160  -29.30502 -42.74071 1.000 46.29307 ?  113 HIS B C   1 
ATOM   1587 O O   . HIS B 1 58  ? 11.41495  -29.17260 -42.65529 1.000 47.73625 ?  113 HIS B O   1 
ATOM   1588 C CB  . HIS B 1 58  ? 9.84134   -31.38696 -44.12008 1.000 53.72463 ?  113 HIS B CB  1 
ATOM   1589 C CG  . HIS B 1 58  ? 8.75944   -32.10586 -44.86269 1.000 57.73923 ?  113 HIS B CG  1 
ATOM   1590 N ND1 . HIS B 1 58  ? 8.74215   -32.20566 -46.23859 1.000 55.67719 ?  113 HIS B ND1 1 
ATOM   1591 C CD2 . HIS B 1 58  ? 7.62612   -32.70577 -44.42564 1.000 54.79017 ?  113 HIS B CD2 1 
ATOM   1592 C CE1 . HIS B 1 58  ? 7.66121   -32.86612 -46.61510 1.000 57.40839 ?  113 HIS B CE1 1 
ATOM   1593 N NE2 . HIS B 1 58  ? 6.96748   -33.18066 -45.53478 1.000 62.00794 ?  113 HIS B NE2 1 
ATOM   1594 N N   . ILE B 1 59  ? 9.33558   -28.93191 -41.79554 1.000 44.16349 ?  114 ILE B N   1 
ATOM   1595 C CA  . ILE B 1 59  ? 9.74055   -28.19982 -40.60463 1.000 40.44200 ?  114 ILE B CA  1 
ATOM   1596 C C   . ILE B 1 59  ? 10.23292  -29.16460 -39.53792 1.000 47.07056 ?  114 ILE B C   1 
ATOM   1597 O O   . ILE B 1 59  ? 9.77141   -30.31240 -39.43299 1.000 50.43838 ?  114 ILE B O   1 
ATOM   1598 C CB  . ILE B 1 59  ? 8.57116   -27.34687 -40.07930 1.000 44.84443 ?  114 ILE B CB  1 
ATOM   1599 C CG1 . ILE B 1 59  ? 7.24874   -28.11284 -40.22261 1.000 47.12305 ?  114 ILE B CG1 1 
ATOM   1600 C CG2 . ILE B 1 59  ? 8.50322   -26.03808 -40.84182 1.000 38.76416 ?  114 ILE B CG2 1 
ATOM   1601 C CD1 . ILE B 1 59  ? 7.07185   -29.37186 -39.32208 1.000 46.61221 ?  114 ILE B CD1 1 
ATOM   1602 N N   . THR B 1 60  ? 11.20260  -28.69585 -38.76520 1.000 40.76625 ?  115 THR B N   1 
ATOM   1603 C CA  . THR B 1 60  ? 11.64774  -29.30461 -37.51741 1.000 38.60977 ?  115 THR B CA  1 
ATOM   1604 C C   . THR B 1 60  ? 11.73607  -28.16072 -36.53470 1.000 41.05669 ?  115 THR B C   1 
ATOM   1605 O O   . THR B 1 60  ? 11.65026  -26.99159 -36.92704 1.000 38.03605 ?  115 THR B O   1 
ATOM   1606 C CB  . THR B 1 60  ? 13.01845  -29.97884 -37.67476 1.000 43.41369 ?  115 THR B CB  1 
ATOM   1607 O OG1 . THR B 1 60  ? 14.03264  -29.01192 -37.39879 1.000 45.55444 ?  115 THR B OG1 1 
ATOM   1608 C CG2 . THR B 1 60  ? 13.22593  -30.52124 -39.11287 1.000 42.67236 ?  115 THR B CG2 1 
ATOM   1609 N N   . PRO B 1 61  ? 11.90901  -28.44136 -35.23749 1.000 42.45217 ?  116 PRO B N   1 
ATOM   1610 C CA  . PRO B 1 61  ? 12.11179  -27.33358 -34.28739 1.000 40.10658 ?  116 PRO B CA  1 
ATOM   1611 C C   . PRO B 1 61  ? 13.35599  -26.50431 -34.56752 1.000 34.63363 ?  116 PRO B C   1 
ATOM   1612 O O   . PRO B 1 61  ? 13.47077  -25.40420 -34.01994 1.000 35.30501 ?  116 PRO B O   1 
ATOM   1613 C CB  . PRO B 1 61  ? 12.19838  -28.04258 -32.92673 1.000 45.13295 ?  116 PRO B CB  1 
ATOM   1614 C CG  . PRO B 1 61  ? 11.36106  -29.26367 -33.12141 1.000 35.18193 ?  116 PRO B CG  1 
ATOM   1615 C CD  . PRO B 1 61  ? 11.70091  -29.71727 -34.52824 1.000 39.42886 ?  116 PRO B CD  1 
ATOM   1616 N N   . GLY B 1 62  ? 14.27740  -26.97516 -35.40649 1.000 33.84628 ?  117 GLY B N   1 
ATOM   1617 C CA  . GLY B 1 62  ? 15.46306  -26.20335 -35.71176 1.000 33.49950 ?  117 GLY B CA  1 
ATOM   1618 C C   . GLY B 1 62  ? 15.37666  -25.39341 -36.99133 1.000 33.04825 ?  117 GLY B C   1 
ATOM   1619 O O   . GLY B 1 62  ? 16.25429  -24.56913 -37.26012 1.000 35.66386 ?  117 GLY B O   1 
ATOM   1620 N N   . THR B 1 63  ? 14.33699  -25.61849 -37.79213 1.000 30.93168 ?  118 THR B N   1 
ATOM   1621 C CA  . THR B 1 63  ? 14.15886  -24.85044 -39.01989 1.000 36.94690 ?  118 THR B CA  1 
ATOM   1622 C C   . THR B 1 63  ? 14.03482  -23.35938 -38.71232 1.000 34.43584 ?  118 THR B C   1 
ATOM   1623 O O   . THR B 1 63  ? 13.31234  -22.94996 -37.79725 1.000 31.54484 ?  118 THR B O   1 
ATOM   1624 C CB  . THR B 1 63  ? 12.91483  -25.31545 -39.77576 1.000 34.71981 ?  118 THR B CB  1 
ATOM   1625 O OG1 . THR B 1 63  ? 12.95090  -26.73331 -39.92644 1.000 41.31215 ?  118 THR B OG1 1 
ATOM   1626 C CG2 . THR B 1 63  ? 12.86079  -24.67571 -41.15595 1.000 35.30913 ?  118 THR B CG2 1 
ATOM   1627 N N   . ALA B 1 64  ? 14.73465  -22.54948 -39.49345 1.000 28.69769 ?  119 ALA B N   1 
ATOM   1628 C CA  . ALA B 1 64  ? 14.75166  -21.10829 -39.31268 1.000 28.29214 ?  119 ALA B CA  1 
ATOM   1629 C C   . ALA B 1 64  ? 13.80903  -20.44623 -40.30029 1.000 22.15321 ?  119 ALA B C   1 
ATOM   1630 O O   . ALA B 1 64  ? 13.38738  -21.04534 -41.29674 1.000 26.81932 ?  119 ALA B O   1 
ATOM   1631 C CB  . ALA B 1 64  ? 16.16238  -20.56078 -39.49317 1.000 24.95479 ?  119 ALA B CB  1 
ATOM   1632 N N   . TYR B 1 65  ? 13.47861  -19.18855 -40.01529 1.000 26.01945 ?  120 TYR B N   1 
ATOM   1633 C CA  . TYR B 1 65  ? 12.54729  -18.47287 -40.87926 1.000 23.70279 ?  120 TYR B CA  1 
ATOM   1634 C C   . TYR B 1 65  ? 13.09271  -18.36961 -42.29356 1.000 24.70724 ?  120 TYR B C   1 
ATOM   1635 O O   . TYR B 1 65  ? 12.32192  -18.35375 -43.26364 1.000 20.55044 ?  120 TYR B O   1 
ATOM   1636 C CB  . TYR B 1 65  ? 12.25186  -17.08786 -40.28076 1.000 26.12869 ?  120 TYR B CB  1 
ATOM   1637 C CG  . TYR B 1 65  ? 11.58290  -16.13179 -41.22667 1.000 24.85372 ?  120 TYR B CG  1 
ATOM   1638 C CD1 . TYR B 1 65  ? 10.26331  -16.32828 -41.63476 1.000 23.78377 ?  120 TYR B CD1 1 
ATOM   1639 C CD2 . TYR B 1 65  ? 12.26891  -15.02028 -41.70930 1.000 29.01478 ?  120 TYR B CD2 1 
ATOM   1640 C CE1 . TYR B 1 65  ? 9.64503   -15.44894 -42.50897 1.000 25.20437 ?  120 TYR B CE1 1 
ATOM   1641 C CE2 . TYR B 1 65  ? 11.66755  -14.13326 -42.57966 1.000 32.14121 ?  120 TYR B CE2 1 
ATOM   1642 C CZ  . TYR B 1 65  ? 10.35401  -14.34211 -42.97368 1.000 30.27956 ?  120 TYR B CZ  1 
ATOM   1643 O OH  . TYR B 1 65  ? 9.78258   -13.44452 -43.84412 1.000 26.76529 ?  120 TYR B OH  1 
ATOM   1644 N N   . GLN B 1 66  ? 14.42214  -18.35419 -42.43185 1.000 25.83826 ?  121 GLN B N   1 
ATOM   1645 C CA  . GLN B 1 66  ? 15.04345  -18.14861 -43.73611 1.000 24.71683 ?  121 GLN B CA  1 
ATOM   1646 C C   . GLN B 1 66  ? 14.72395  -19.27223 -44.70033 1.000 26.70813 ?  121 GLN B C   1 
ATOM   1647 O O   . GLN B 1 66  ? 14.65809  -19.04629 -45.91332 1.000 24.88964 ?  121 GLN B O   1 
ATOM   1648 C CB  . GLN B 1 66  ? 16.55412  -18.02175 -43.57768 1.000 28.22057 ?  121 GLN B CB  1 
ATOM   1649 C CG  . GLN B 1 66  ? 17.02507  -16.63100 -43.13798 1.000 32.13274 ?  121 GLN B CG  1 
ATOM   1650 C CD  . GLN B 1 66  ? 16.42915  -16.18437 -41.81988 1.000 27.48442 ?  121 GLN B CD  1 
ATOM   1651 O OE1 . GLN B 1 66  ? 16.30149  -16.96955 -40.87462 1.000 30.24447 ?  121 GLN B OE1 1 
ATOM   1652 N NE2 . GLN B 1 66  ? 16.04468  -14.91121 -41.75394 1.000 30.24396 ?  121 GLN B NE2 1 
ATOM   1653 N N   . SER B 1 67  ? 14.51594  -20.48677 -44.19079 1.000 25.18990 ?  122 SER B N   1 
ATOM   1654 C CA  . SER B 1 67  ? 14.15304  -21.58011 -45.07954 1.000 25.68084 ?  122 SER B CA  1 
ATOM   1655 C C   . SER B 1 67  ? 12.72380  -21.42784 -45.58789 1.000 24.22993 ?  122 SER B C   1 
ATOM   1656 O O   . SER B 1 67  ? 12.45086  -21.68749 -46.76351 1.000 27.52158 ?  122 SER B O   1 
ATOM   1657 C CB  . SER B 1 67  ? 14.34404  -22.91301 -44.36252 1.000 27.36276 ?  122 SER B CB  1 
ATOM   1658 O OG  . SER B 1 67  ? 15.61000  -22.94209 -43.72570 1.000 34.93889 ?  122 SER B OG  1 
ATOM   1659 N N   . PHE B 1 68  ? 11.79691  -21.03626 -44.71035 1.000 24.58429 ?  123 PHE B N   1 
ATOM   1660 C CA  . PHE B 1 68  ? 10.44001  -20.71587 -45.14050 1.000 24.68825 ?  123 PHE B CA  1 
ATOM   1661 C C   . PHE B 1 68  ? 10.47393  -19.60914 -46.17998 1.000 26.32021 ?  123 PHE B C   1 
ATOM   1662 O O   . PHE B 1 68  ? 9.88936   -19.73161 -47.26134 1.000 27.78769 ?  123 PHE B O   1 
ATOM   1663 C CB  . PHE B 1 68  ? 9.59494   -20.30796 -43.92555 1.000 22.54332 ?  123 PHE B CB  1 
ATOM   1664 C CG  . PHE B 1 68  ? 8.17376   -19.84062 -44.26129 1.000 22.39353 ?  123 PHE B CG  1 
ATOM   1665 C CD1 . PHE B 1 68  ? 7.15885   -20.75228 -44.50928 1.000 22.48359 ?  123 PHE B CD1 1 
ATOM   1666 C CD2 . PHE B 1 68  ? 7.85851   -18.49243 -44.28396 1.000 22.69442 ?  123 PHE B CD2 1 
ATOM   1667 C CE1 . PHE B 1 68  ? 5.86500   -20.32690 -44.79300 1.000 22.37823 ?  123 PHE B CE1 1 
ATOM   1668 C CE2 . PHE B 1 68  ? 6.55437   -18.05131 -44.56285 1.000 23.22539 ?  123 PHE B CE2 1 
ATOM   1669 C CZ  . PHE B 1 68  ? 5.56523   -18.97972 -44.81771 1.000 24.86546 ?  123 PHE B CZ  1 
ATOM   1670 N N   . GLU B 1 69  ? 11.19456  -18.53507 -45.87562 1.000 23.02777 ?  124 GLU B N   1 
ATOM   1671 C CA  . GLU B 1 69  ? 11.24676  -17.38851 -46.77350 1.000 26.87120 ?  124 GLU B CA  1 
ATOM   1672 C C   . GLU B 1 69  ? 11.85443  -17.76992 -48.11952 1.000 27.79556 ?  124 GLU B C   1 
ATOM   1673 O O   . GLU B 1 69  ? 11.42158  -17.27641 -49.17063 1.000 26.58677 ?  124 GLU B O   1 
ATOM   1674 C CB  . GLU B 1 69  ? 12.03851  -16.27867 -46.08811 1.000 26.93510 ?  124 GLU B CB  1 
ATOM   1675 C CG  . GLU B 1 69  ? 12.17882  -15.00680 -46.85420 1.000 33.12457 ?  124 GLU B CG  1 
ATOM   1676 C CD  . GLU B 1 69  ? 13.14216  -14.05862 -46.15080 1.000 35.93178 ?  124 GLU B CD  1 
ATOM   1677 O OE1 . GLU B 1 69  ? 14.23371  -14.52179 -45.76323 1.000 36.84189 ?  124 GLU B OE1 1 
ATOM   1678 O OE2 . GLU B 1 69  ? 12.81289  -12.86472 -45.99019 1.000 35.38516 -1 124 GLU B OE2 1 
ATOM   1679 N N   . GLN B 1 70  ? 12.84350  -18.67432 -48.10951 1.000 26.68045 ?  125 GLN B N   1 
ATOM   1680 C CA  . GLN B 1 70  ? 13.41904  -19.17185 -49.35400 1.000 25.54546 ?  125 GLN B CA  1 
ATOM   1681 C C   . GLN B 1 70  ? 12.36171  -19.80058 -50.24779 1.000 28.11513 ?  125 GLN B C   1 
ATOM   1682 O O   . GLN B 1 70  ? 12.32966  -19.56165 -51.45932 1.000 28.73792 ?  125 GLN B O   1 
ATOM   1683 C CB  . GLN B 1 70  ? 14.49974  -20.20403 -49.04812 1.000 30.08250 ?  125 GLN B CB  1 
ATOM   1684 C CG  . GLN B 1 70  ? 15.88243  -19.68884 -48.96526 1.000 38.66412 ?  125 GLN B CG  1 
ATOM   1685 C CD  . GLN B 1 70  ? 16.88321  -20.81537 -48.74838 1.000 37.11445 ?  125 GLN B CD  1 
ATOM   1686 O OE1 . GLN B 1 70  ? 17.89163  -20.62362 -48.07955 1.000 44.60623 ?  125 GLN B OE1 1 
ATOM   1687 N NE2 . GLN B 1 70  ? 16.58381  -22.00795 -49.28773 1.000 34.45750 ?  125 GLN B NE2 1 
ATOM   1688 N N   . VAL B 1 71  ? 11.51402  -20.65277 -49.67584 1.000 24.71809 ?  126 VAL B N   1 
ATOM   1689 C CA  . VAL B 1 71  ? 10.51963  -21.33748 -50.48638 1.000 27.52772 ?  126 VAL B CA  1 
ATOM   1690 C C   . VAL B 1 71  ? 9.47516   -20.35337 -51.00259 1.000 27.92339 ?  126 VAL B C   1 
ATOM   1691 O O   . VAL B 1 71  ? 9.05790   -20.42283 -52.16435 1.000 28.43274 ?  126 VAL B O   1 
ATOM   1692 C CB  . VAL B 1 71  ? 9.89520   -22.47932 -49.66624 1.000 30.47739 ?  126 VAL B CB  1 
ATOM   1693 C CG1 . VAL B 1 71  ? 8.74034   -23.13270 -50.42632 1.000 30.95604 ?  126 VAL B CG1 1 
ATOM   1694 C CG2 . VAL B 1 71  ? 10.97841  -23.49097 -49.32331 1.000 29.72158 ?  126 VAL B CG2 1 
ATOM   1695 N N   . VAL B 1 72  ? 9.05302   -19.40739 -50.15923 1.000 24.73893 ?  127 VAL B N   1 
ATOM   1696 C CA  . VAL B 1 72  ? 7.97818   -18.50470 -50.54942 1.000 26.91511 ?  127 VAL B CA  1 
ATOM   1697 C C   . VAL B 1 72  ? 8.47614   -17.47254 -51.56265 1.000 25.74964 ?  127 VAL B C   1 
ATOM   1698 O O   . VAL B 1 72  ? 7.75423   -17.10879 -52.49971 1.000 24.77794 ?  127 VAL B O   1 
ATOM   1699 C CB  . VAL B 1 72  ? 7.36519   -17.84842 -49.29643 1.000 25.61609 ?  127 VAL B CB  1 
ATOM   1700 C CG1 . VAL B 1 72  ? 6.22338   -16.97746 -49.69598 1.000 23.53187 ?  127 VAL B CG1 1 
ATOM   1701 C CG2 . VAL B 1 72  ? 6.89187   -18.92959 -48.33353 1.000 25.12403 ?  127 VAL B CG2 1 
ATOM   1702 N N   . ASN B 1 73  ? 9.71560   -16.99720 -51.40792 1.000 24.02996 ?  128 ASN B N   1 
ATOM   1703 C CA  . ASN B 1 73  ? 10.30428  -16.12722 -52.43431 1.000 27.62873 ?  128 ASN B CA  1 
ATOM   1704 C C   . ASN B 1 73  ? 10.26104  -16.78216 -53.80815 1.000 29.83755 ?  128 ASN B C   1 
ATOM   1705 O O   . ASN B 1 73  ? 10.02436  -16.11877 -54.82198 1.000 27.74851 ?  128 ASN B O   1 
ATOM   1706 C CB  . ASN B 1 73  ? 11.74993  -15.78373 -52.08858 1.000 26.27527 ?  128 ASN B CB  1 
ATOM   1707 C CG  . ASN B 1 73  ? 11.86634  -14.79197 -50.95986 1.000 28.76229 ?  128 ASN B CG  1 
ATOM   1708 O OD1 . ASN B 1 73  ? 10.88020  -14.20071 -50.51201 1.000 28.79149 ?  128 ASN B OD1 1 
ATOM   1709 N ND2 . ASN B 1 73  ? 13.09302  -14.57681 -50.50754 1.000 33.93788 ?  128 ASN B ND2 1 
ATOM   1710 N N   . GLU B 1 74  ? 10.51671  -18.08767 -53.85886 1.000 28.13611 ?  129 GLU B N   1 
ATOM   1711 C CA  . GLU B 1 74  ? 10.45569  -18.82211 -55.11472 1.000 34.41565 ?  129 GLU B CA  1 
ATOM   1712 C C   . GLU B 1 74  ? 9.04390   -18.80470 -55.69934 1.000 31.58587 ?  129 GLU B C   1 
ATOM   1713 O O   . GLU B 1 74  ? 8.85965   -18.64508 -56.91371 1.000 30.81353 ?  129 GLU B O   1 
ATOM   1714 C CB  . GLU B 1 74  ? 10.93040  -20.25443 -54.85170 1.000 33.87420 ?  129 GLU B CB  1 
ATOM   1715 C CG  . GLU B 1 74  ? 11.21499  -21.09078 -56.05750 1.000 39.92847 ?  129 GLU B CG  1 
ATOM   1716 C CD  . GLU B 1 74  ? 12.21952  -20.43800 -56.97671 1.000 54.48131 ?  129 GLU B CD  1 
ATOM   1717 O OE1 . GLU B 1 74  ? 11.97710  -20.44749 -58.20261 1.000 56.05765 ?  129 GLU B OE1 1 
ATOM   1718 O OE2 . GLU B 1 74  ? 13.23683  -19.88502 -56.47231 1.000 55.63692 -1 129 GLU B OE2 1 
ATOM   1719 N N   . LEU B 1 75  ? 8.03769   -18.94787 -54.83928 1.000 27.73888 ?  130 LEU B N   1 
ATOM   1720 C CA  . LEU B 1 75  ? 6.65221   -18.96692 -55.28610 1.000 26.28682 ?  130 LEU B CA  1 
ATOM   1721 C C   . LEU B 1 75  ? 6.25305   -17.64873 -55.94958 1.000 27.32109 ?  130 LEU B C   1 
ATOM   1722 O O   . LEU B 1 75  ? 5.45900   -17.64478 -56.90203 1.000 29.38696 ?  130 LEU B O   1 
ATOM   1723 C CB  . LEU B 1 75  ? 5.75692   -19.28824 -54.08564 1.000 24.91096 ?  130 LEU B CB  1 
ATOM   1724 C CG  . LEU B 1 75  ? 4.27059   -18.94713 -54.16700 1.000 28.57884 ?  130 LEU B CG  1 
ATOM   1725 C CD1 . LEU B 1 75  ? 3.62476   -19.91960 -55.11349 1.000 25.66848 ?  130 LEU B CD1 1 
ATOM   1726 C CD2 . LEU B 1 75  ? 3.58571   -18.98452 -52.78513 1.000 22.59775 ?  130 LEU B CD2 1 
ATOM   1727 N N   . PHE B 1 76  ? 6.80398   -16.52724 -55.48057 1.000 24.80471 ?  131 PHE B N   1 
ATOM   1728 C CA  . PHE B 1 76  ? 6.48500   -15.20671 -56.01434 1.000 30.28898 ?  131 PHE B CA  1 
ATOM   1729 C C   . PHE B 1 76  ? 7.52928   -14.70062 -57.00939 1.000 29.90160 ?  131 PHE B C   1 
ATOM   1730 O O   . PHE B 1 76  ? 7.51476   -13.52159 -57.35031 1.000 29.11901 ?  131 PHE B O   1 
ATOM   1731 C CB  . PHE B 1 76  ? 6.33299   -14.18587 -54.87678 1.000 24.95517 ?  131 PHE B CB  1 
ATOM   1732 C CG  . PHE B 1 76  ? 5.16604   -14.46484 -53.94796 1.000 23.01464 ?  131 PHE B CG  1 
ATOM   1733 C CD1 . PHE B 1 76  ? 3.86730   -14.37418 -54.39929 1.000 24.35693 ?  131 PHE B CD1 1 
ATOM   1734 C CD2 . PHE B 1 76  ? 5.37907   -14.78620 -52.62133 1.000 20.89027 ?  131 PHE B CD2 1 
ATOM   1735 C CE1 . PHE B 1 76  ? 2.80224   -14.62133 -53.54989 1.000 24.29001 ?  131 PHE B CE1 1 
ATOM   1736 C CE2 . PHE B 1 76  ? 4.32316   -15.03471 -51.77272 1.000 24.15464 ?  131 PHE B CE2 1 
ATOM   1737 C CZ  . PHE B 1 76  ? 3.03476   -14.94462 -52.23203 1.000 22.14389 ?  131 PHE B CZ  1 
ATOM   1738 N N   . ARG B 1 77  ? 8.44226   -15.55280 -57.47861 1.000 31.03595 ?  132 ARG B N   1 
ATOM   1739 C CA  . ARG B 1 77  ? 9.56242   -15.03353 -58.25906 1.000 33.27726 ?  132 ARG B CA  1 
ATOM   1740 C C   . ARG B 1 77  ? 9.09508   -14.33346 -59.52935 1.000 33.52032 ?  132 ARG B C   1 
ATOM   1741 O O   . ARG B 1 77  ? 9.71608   -13.35891 -59.95944 1.000 30.76916 ?  132 ARG B O   1 
ATOM   1742 C CB  . ARG B 1 77  ? 10.53283  -16.15095 -58.61235 1.000 34.18261 ?  132 ARG B CB  1 
ATOM   1743 C CG  . ARG B 1 77  ? 9.93044   -17.21833 -59.52181 1.000 48.91685 ?  132 ARG B CG  1 
ATOM   1744 C CD  . ARG B 1 77  ? 10.88711  -18.33759 -60.00053 1.000 48.79687 ?  132 ARG B CD  1 
ATOM   1745 N NE  . ARG B 1 77  ? 12.15599  -17.84193 -60.54549 1.000 55.23520 ?  132 ARG B NE  1 
ATOM   1746 C CZ  . ARG B 1 77  ? 13.19901  -17.43781 -59.82085 1.000 55.05282 ?  132 ARG B CZ  1 
ATOM   1747 N NH1 . ARG B 1 77  ? 13.17639  -17.54311 -58.49309 1.000 54.07757 ?  132 ARG B NH1 1 
ATOM   1748 N NH2 . ARG B 1 77  ? 14.29491  -16.98499 -60.42888 1.000 58.32334 ?  132 ARG B NH2 1 
ATOM   1749 N N   . ASP B 1 78  ? 8.00794   -14.80702 -60.14406 1.000 33.42642 ?  133 ASP B N   1 
ATOM   1750 C CA  . ASP B 1 78  ? 7.51824   -14.20302 -61.37891 1.000 30.78717 ?  133 ASP B CA  1 
ATOM   1751 C C   . ASP B 1 78  ? 6.46983   -13.11293 -61.12738 1.000 35.71507 ?  133 ASP B C   1 
ATOM   1752 O O   . ASP B 1 78  ? 5.87579   -12.58133 -62.07995 1.000 31.79505 ?  133 ASP B O   1 
ATOM   1753 C CB  . ASP B 1 78  ? 7.00459   -15.29380 -62.31191 1.000 31.32654 ?  133 ASP B CB  1 
ATOM   1754 C CG  . ASP B 1 78  ? 8.15982   -16.14541 -62.89008 1.000 39.21272 ?  133 ASP B CG  1 
ATOM   1755 O OD1 . ASP B 1 78  ? 9.19607   -15.56335 -63.28245 1.000 42.19275 ?  133 ASP B OD1 1 
ATOM   1756 O OD2 . ASP B 1 78  ? 8.06659   -17.39193 -62.91689 1.000 45.32123 -1 133 ASP B OD2 1 
ATOM   1757 N N   . GLY B 1 79  ? 6.28184   -12.72209 -59.87661 1.000 31.46513 ?  134 GLY B N   1 
ATOM   1758 C CA  . GLY B 1 79  ? 5.35895   -11.64993 -59.55365 1.000 31.88436 ?  134 GLY B CA  1 
ATOM   1759 C C   . GLY B 1 79  ? 4.37395   -12.09983 -58.50051 1.000 27.26539 ?  134 GLY B C   1 
ATOM   1760 O O   . GLY B 1 79  ? 4.10330   -13.29613 -58.32848 1.000 28.22990 ?  134 GLY B O   1 
ATOM   1761 N N   . VAL B 1 80  ? 3.83964   -11.15024 -57.78085 1.000 27.28913 ?  135 VAL B N   1 
ATOM   1762 C CA  . VAL B 1 80  ? 2.78313   -11.41057 -56.82528 1.000 28.14523 ?  135 VAL B CA  1 
ATOM   1763 C C   . VAL B 1 80  ? 1.44006   -11.29418 -57.53997 1.000 29.85747 ?  135 VAL B C   1 
ATOM   1764 O O   . VAL B 1 80  ? 1.23889   -10.40620 -58.38163 1.000 26.30886 ?  135 VAL B O   1 
ATOM   1765 C CB  . VAL B 1 80  ? 2.89833   -10.44353 -55.63361 1.000 28.07833 ?  135 VAL B CB  1 
ATOM   1766 C CG1 . VAL B 1 80  ? 1.87892   -10.77204 -54.56284 1.000 27.88281 ?  135 VAL B CG1 1 
ATOM   1767 C CG2 . VAL B 1 80  ? 4.30507   -10.47985 -55.06482 1.000 28.05016 ?  135 VAL B CG2 1 
ATOM   1768 N N   . ASN B 1 81  ? 0.52992   -12.22329 -57.24394 1.000 28.60301 ?  136 ASN B N   1 
ATOM   1769 C CA  . ASN B 1 81  ? -0.87221  -12.07099 -57.61052 1.000 27.01947 ?  136 ASN B CA  1 
ATOM   1770 C C   . ASN B 1 81  ? -1.70349  -12.73039 -56.51684 1.000 28.43542 ?  136 ASN B C   1 
ATOM   1771 O O   . ASN B 1 81  ? -1.16767  -13.37860 -55.61300 1.000 25.87293 ?  136 ASN B O   1 
ATOM   1772 C CB  . ASN B 1 81  ? -1.16024  -12.65027 -59.01048 1.000 27.97289 ?  136 ASN B CB  1 
ATOM   1773 C CG  . ASN B 1 81  ? -1.02335  -14.16476 -59.06497 1.000 29.75758 ?  136 ASN B CG  1 
ATOM   1774 O OD1 . ASN B 1 81  ? -1.74499  -14.89091 -58.37321 1.000 28.78364 ?  136 ASN B OD1 1 
ATOM   1775 N ND2 . ASN B 1 81  ? -0.10962  -14.65199 -59.91037 1.000 25.82572 ?  136 ASN B ND2 1 
ATOM   1776 N N   . TRP B 1 82  ? -3.02715  -12.58109 -56.60587 1.000 24.95016 ?  137 TRP B N   1 
ATOM   1777 C CA  . TRP B 1 82  ? -3.85359  -13.01878 -55.48992 1.000 24.50673 ?  137 TRP B CA  1 
ATOM   1778 C C   . TRP B 1 82  ? -3.88077  -14.54010 -55.37662 1.000 24.49727 ?  137 TRP B C   1 
ATOM   1779 O O   . TRP B 1 82  ? -3.98951  -15.07098 -54.26672 1.000 23.65592 ?  137 TRP B O   1 
ATOM   1780 C CB  . TRP B 1 82  ? -5.27815  -12.45036 -55.60847 1.000 28.19393 ?  137 TRP B CB  1 
ATOM   1781 C CG  . TRP B 1 82  ? -5.40670  -10.94510 -55.32423 1.000 32.69395 ?  137 TRP B CG  1 
ATOM   1782 C CD1 . TRP B 1 82  ? -5.74378  -9.95880  -56.22656 1.000 34.06325 ?  137 TRP B CD1 1 
ATOM   1783 C CD2 . TRP B 1 82  ? -5.22425  -10.27669 -54.05905 1.000 25.50857 ?  137 TRP B CD2 1 
ATOM   1784 N NE1 . TRP B 1 82  ? -5.76604  -8.72512  -55.60034 1.000 31.83374 ?  137 TRP B NE1 1 
ATOM   1785 C CE2 . TRP B 1 82  ? -5.46118  -8.89273  -54.27506 1.000 31.83536 ?  137 TRP B CE2 1 
ATOM   1786 C CE3 . TRP B 1 82  ? -4.89256  -10.71043 -52.77329 1.000 26.67652 ?  137 TRP B CE3 1 
ATOM   1787 C CZ2 . TRP B 1 82  ? -5.36853  -7.94733  -53.25042 1.000 29.35007 ?  137 TRP B CZ2 1 
ATOM   1788 C CZ3 . TRP B 1 82  ? -4.79059  -9.75750  -51.75041 1.000 29.47872 ?  137 TRP B CZ3 1 
ATOM   1789 C CH2 . TRP B 1 82  ? -5.03199  -8.39980  -51.99968 1.000 30.13952 ?  137 TRP B CH2 1 
ATOM   1790 N N   . GLY B 1 83  ? -3.77662  -15.25997 -56.49388 1.000 24.22024 ?  138 GLY B N   1 
ATOM   1791 C CA  . GLY B 1 83  ? -3.77646  -16.71556 -56.41799 1.000 26.60060 ?  138 GLY B CA  1 
ATOM   1792 C C   . GLY B 1 83  ? -2.50937  -17.25378 -55.78216 1.000 24.92399 ?  138 GLY B C   1 
ATOM   1793 O O   . GLY B 1 83  ? -2.54065  -18.23869 -55.03790 1.000 22.25746 ?  138 GLY B O   1 
ATOM   1794 N N   . ARG B 1 84  ? -1.38282  -16.60463 -56.04214 1.000 21.51357 ?  139 ARG B N   1 
ATOM   1795 C CA  . ARG B 1 84  ? -0.14840  -17.00330 -55.37449 1.000 22.79288 ?  139 ARG B CA  1 
ATOM   1796 C C   . ARG B 1 84  ? -0.20015  -16.69081 -53.88130 1.000 24.30113 ?  139 ARG B C   1 
ATOM   1797 O O   . ARG B 1 84  ? 0.30087   -17.46909 -53.06044 1.000 22.17662 ?  139 ARG B O   1 
ATOM   1798 C CB  . ARG B 1 84  ? 1.05352   -16.32959 -56.04800 1.000 24.66474 ?  139 ARG B CB  1 
ATOM   1799 C CG  . ARG B 1 84  ? 1.52233   -17.09399 -57.27339 1.000 27.46655 ?  139 ARG B CG  1 
ATOM   1800 C CD  . ARG B 1 84  ? 2.41634   -16.27748 -58.17515 1.000 28.93138 ?  139 ARG B CD  1 
ATOM   1801 N NE  . ARG B 1 84  ? 2.62844   -16.96026 -59.45057 1.000 28.64488 ?  139 ARG B NE  1 
ATOM   1802 C CZ  . ARG B 1 84  ? 3.16255   -16.39672 -60.52749 1.000 32.28078 ?  139 ARG B CZ  1 
ATOM   1803 N NH1 . ARG B 1 84  ? 3.56718   -15.12511 -60.49234 1.000 32.74615 ?  139 ARG B NH1 1 
ATOM   1804 N NH2 . ARG B 1 84  ? 3.29470   -17.10601 -61.63766 1.000 31.33736 ?  139 ARG B NH2 1 
ATOM   1805 N N   . ILE B 1 85  ? -0.81242  -15.56390 -53.50537 1.000 19.83002 ?  140 ILE B N   1 
ATOM   1806 C CA  . ILE B 1 85  ? -1.04477  -15.29145 -52.08865 1.000 21.37995 ?  140 ILE B CA  1 
ATOM   1807 C C   . ILE B 1 85  ? -1.93550  -16.37168 -51.47271 1.000 19.75428 ?  140 ILE B C   1 
ATOM   1808 O O   . ILE B 1 85  ? -1.67050  -16.84649 -50.36466 1.000 16.81104 ?  140 ILE B O   1 
ATOM   1809 C CB  . ILE B 1 85  ? -1.63630  -13.87184 -51.90436 1.000 25.79428 ?  140 ILE B CB  1 
ATOM   1810 C CG1 . ILE B 1 85  ? -0.60491  -12.81469 -52.32479 1.000 24.98024 ?  140 ILE B CG1 1 
ATOM   1811 C CG2 . ILE B 1 85  ? -2.09045  -13.67046 -50.46305 1.000 22.62163 ?  140 ILE B CG2 1 
ATOM   1812 C CD1 . ILE B 1 85  ? -1.00170  -11.34790 -52.07125 1.000 23.14336 ?  140 ILE B CD1 1 
ATOM   1813 N N   . VAL B 1 86  ? -2.98962  -16.79454 -52.18125 1.000 18.39467 ?  141 VAL B N   1 
ATOM   1814 C CA  . VAL B 1 86  ? -3.81458  -17.90672 -51.69772 1.000 18.06718 ?  141 VAL B CA  1 
ATOM   1815 C C   . VAL B 1 86  ? -2.96711  -19.16774 -51.49974 1.000 20.74862 ?  141 VAL B C   1 
ATOM   1816 O O   . VAL B 1 86  ? -3.10701  -19.87939 -50.49511 1.000 19.40349 ?  141 VAL B O   1 
ATOM   1817 C CB  . VAL B 1 86  ? -4.99411  -18.17319 -52.65860 1.000 22.11884 ?  141 VAL B CB  1 
ATOM   1818 C CG1 . VAL B 1 86  ? -5.77031  -19.42892 -52.21493 1.000 21.94103 ?  141 VAL B CG1 1 
ATOM   1819 C CG2 . VAL B 1 86  ? -5.94575  -16.97568 -52.71284 1.000 20.23623 ?  141 VAL B CG2 1 
ATOM   1820 N N   . ALA B 1 87  ? -2.05895  -19.45940 -52.43244 1.000 19.60360 ?  142 ALA B N   1 
ATOM   1821 C CA  . ALA B 1 87  ? -1.23102  -20.65181 -52.26635 1.000 18.06904 ?  142 ALA B CA  1 
ATOM   1822 C C   . ALA B 1 87  ? -0.30961  -20.53375 -51.05102 1.000 20.84904 ?  142 ALA B C   1 
ATOM   1823 O O   . ALA B 1 87  ? -0.04444  -21.52864 -50.35724 1.000 21.23604 ?  142 ALA B O   1 
ATOM   1824 C CB  . ALA B 1 87  ? -0.43414  -20.90035 -53.54248 1.000 21.91023 ?  142 ALA B CB  1 
ATOM   1825 N N   . PHE B 1 88  ? 0.19573   -19.32758 -50.78275 1.000 18.37459 ?  143 PHE B N   1 
ATOM   1826 C CA  . PHE B 1 88  ? 1.05129   -19.11360 -49.61965 1.000 19.74545 ?  143 PHE B CA  1 
ATOM   1827 C C   . PHE B 1 88  ? 0.30393   -19.45192 -48.33227 1.000 15.97987 ?  143 PHE B C   1 
ATOM   1828 O O   . PHE B 1 88  ? 0.86487   -20.09975 -47.44350 1.000 20.44555 ?  143 PHE B O   1 
ATOM   1829 C CB  . PHE B 1 88  ? 1.59547   -17.66306 -49.65880 1.000 19.46070 ?  143 PHE B CB  1 
ATOM   1830 C CG  . PHE B 1 88  ? 1.93905   -17.05475 -48.31053 1.000 19.14324 ?  143 PHE B CG  1 
ATOM   1831 C CD1 . PHE B 1 88  ? 0.96989   -16.37766 -47.56774 1.000 23.06861 ?  143 PHE B CD1 1 
ATOM   1832 C CD2 . PHE B 1 88  ? 3.24076   -17.08398 -47.82873 1.000 24.13519 ?  143 PHE B CD2 1 
ATOM   1833 C CE1 . PHE B 1 88  ? 1.28005   -15.79399 -46.34790 1.000 22.68588 ?  143 PHE B CE1 1 
ATOM   1834 C CE2 . PHE B 1 88  ? 3.56703   -16.49759 -46.60648 1.000 21.42169 ?  143 PHE B CE2 1 
ATOM   1835 C CZ  . PHE B 1 88  ? 2.59049   -15.86245 -45.86449 1.000 20.88564 ?  143 PHE B CZ  1 
ATOM   1836 N N   . PHE B 1 89  ? -0.98729  -19.09502 -48.23578 1.000 15.99250 ?  144 PHE B N   1 
ATOM   1837 C CA  . PHE B 1 89  ? -1.75797  -19.46143 -47.04616 1.000 15.91097 ?  144 PHE B CA  1 
ATOM   1838 C C   . PHE B 1 89  ? -1.92349  -20.97828 -46.94648 1.000 20.86744 ?  144 PHE B C   1 
ATOM   1839 O O   . PHE B 1 89  ? -1.67537  -21.56982 -45.88370 1.000 17.55575 ?  144 PHE B O   1 
ATOM   1840 C CB  . PHE B 1 89  ? -3.12516  -18.75562 -47.04379 1.000 19.35694 ?  144 PHE B CB  1 
ATOM   1841 C CG  . PHE B 1 89  ? -3.07114  -17.32354 -46.52582 1.000 23.04036 ?  144 PHE B CG  1 
ATOM   1842 C CD1 . PHE B 1 89  ? -2.78121  -16.27589 -47.38180 1.000 20.23705 ?  144 PHE B CD1 1 
ATOM   1843 C CD2 . PHE B 1 89  ? -3.28229  -17.04744 -45.17243 1.000 20.48929 ?  144 PHE B CD2 1 
ATOM   1844 C CE1 . PHE B 1 89  ? -2.70181  -14.96458 -46.91031 1.000 22.20479 ?  144 PHE B CE1 1 
ATOM   1845 C CE2 . PHE B 1 89  ? -3.21488  -15.75180 -44.68272 1.000 23.08246 ?  144 PHE B CE2 1 
ATOM   1846 C CZ  . PHE B 1 89  ? -2.92345  -14.69800 -45.54709 1.000 24.02777 ?  144 PHE B CZ  1 
ATOM   1847 N N   . SER B 1 90  ? -2.30146  -21.62584 -48.06085 1.000 19.90961 ?  145 SER B N   1 
ATOM   1848 C CA  . SER B 1 90  ? -2.50647  -23.07644 -48.08152 1.000 20.17447 ?  145 SER B CA  1 
ATOM   1849 C C   . SER B 1 90  ? -1.21615  -23.81522 -47.74939 1.000 20.06866 ?  145 SER B C   1 
ATOM   1850 O O   . SER B 1 90  ? -1.23354  -24.84795 -47.06599 1.000 24.55060 ?  145 SER B O   1 
ATOM   1851 C CB  . SER B 1 90  ? -3.03006  -23.51300 -49.45717 1.000 21.91111 ?  145 SER B CB  1 
ATOM   1852 O OG  . SER B 1 90  ? -4.28788  -22.90841 -49.75188 1.000 26.00808 ?  145 SER B OG  1 
ATOM   1853 N N   . PHE B 1 91  ? -0.08391  -23.28012 -48.20740 1.000 20.52252 ?  146 PHE B N   1 
ATOM   1854 C CA  . PHE B 1 91  ? 1.21959   -23.84520 -47.86698 1.000 21.18454 ?  146 PHE B CA  1 
ATOM   1855 C C   . PHE B 1 91  ? 1.48591   -23.75626 -46.36894 1.000 22.44319 ?  146 PHE B C   1 
ATOM   1856 O O   . PHE B 1 91  ? 1.89733   -24.73995 -45.73865 1.000 21.10136 ?  146 PHE B O   1 
ATOM   1857 C CB  . PHE B 1 91  ? 2.29041   -23.11180 -48.67422 1.000 20.06792 ?  146 PHE B CB  1 
ATOM   1858 C CG  . PHE B 1 91  ? 3.69674   -23.43764 -48.29046 1.000 24.54322 ?  146 PHE B CG  1 
ATOM   1859 C CD1 . PHE B 1 91  ? 4.20100   -24.72115 -48.45032 1.000 28.39922 ?  146 PHE B CD1 1 
ATOM   1860 C CD2 . PHE B 1 91  ? 4.53754   -22.43993 -47.81922 1.000 22.79706 ?  146 PHE B CD2 1 
ATOM   1861 C CE1 . PHE B 1 91  ? 5.53222   -25.01194 -48.12278 1.000 28.16672 ?  146 PHE B CE1 1 
ATOM   1862 C CE2 . PHE B 1 91  ? 5.87456   -22.71534 -47.48463 1.000 29.39841 ?  146 PHE B CE2 1 
ATOM   1863 C CZ  . PHE B 1 91  ? 6.36987   -24.01153 -47.63903 1.000 29.39878 ?  146 PHE B CZ  1 
ATOM   1864 N N   . GLY B 1 92  ? 1.24830   -22.58324 -45.77384 1.000 21.46753 ?  147 GLY B N   1 
ATOM   1865 C CA  . GLY B 1 92  ? 1.38384   -22.46888 -44.33239 1.000 18.15780 ?  147 GLY B CA  1 
ATOM   1866 C C   . GLY B 1 92  ? 0.47687   -23.42869 -43.59360 1.000 22.34647 ?  147 GLY B C   1 
ATOM   1867 O O   . GLY B 1 92  ? 0.87558   -24.03363 -42.59622 1.000 20.42099 ?  147 GLY B O   1 
ATOM   1868 N N   . GLY B 1 93  ? -0.76422  -23.57183 -44.06620 1.000 23.48822 ?  148 GLY B N   1 
ATOM   1869 C CA  . GLY B 1 93  ? -1.69990  -24.46731 -43.41444 1.000 20.57189 ?  148 GLY B CA  1 
ATOM   1870 C C   . GLY B 1 93  ? -1.26012  -25.91477 -43.50046 1.000 21.93078 ?  148 GLY B C   1 
ATOM   1871 O O   . GLY B 1 93  ? -1.36185  -26.66106 -42.52716 1.000 23.40894 ?  148 GLY B O   1 
ATOM   1872 N N   . ALA B 1 94  ? -0.74557  -26.32054 -44.65820 1.000 20.90452 ?  149 ALA B N   1 
ATOM   1873 C CA  . ALA B 1 94  ? -0.17792  -27.66162 -44.78798 1.000 26.67039 ?  149 ALA B CA  1 
ATOM   1874 C C   . ALA B 1 94  ? 0.99756   -27.88131 -43.83276 1.000 27.56951 ?  149 ALA B C   1 
ATOM   1875 O O   . ALA B 1 94  ? 1.12028   -28.95734 -43.23939 1.000 25.25054 ?  149 ALA B O   1 
ATOM   1876 C CB  . ALA B 1 94  ? 0.25364   -27.89763 -46.23232 1.000 28.69592 ?  149 ALA B CB  1 
ATOM   1877 N N   . LEU B 1 95  ? 1.88549   -26.88673 -43.68658 1.000 21.74474 ?  150 LEU B N   1 
ATOM   1878 C CA  . LEU B 1 95  ? 2.99198   -26.99973 -42.73147 1.000 25.52135 ?  150 LEU B CA  1 
ATOM   1879 C C   . LEU B 1 95  ? 2.49444   -27.17295 -41.30402 1.000 24.47033 ?  150 LEU B C   1 
ATOM   1880 O O   . LEU B 1 95  ? 3.14683   -27.85307 -40.50315 1.000 22.55408 ?  150 LEU B O   1 
ATOM   1881 C CB  . LEU B 1 95  ? 3.91183   -25.77107 -42.79375 1.000 23.59732 ?  150 LEU B CB  1 
ATOM   1882 C CG  . LEU B 1 95  ? 4.75519   -25.50406 -44.03625 1.000 22.44884 ?  150 LEU B CG  1 
ATOM   1883 C CD1 . LEU B 1 95  ? 5.41189   -24.11577 -43.92766 1.000 24.97448 ?  150 LEU B CD1 1 
ATOM   1884 C CD2 . LEU B 1 95  ? 5.81666   -26.62362 -44.22571 1.000 26.57837 ?  150 LEU B CD2 1 
ATOM   1885 N N   . CYS B 1 96  ? 1.34032   -26.58390 -40.96871 1.000 19.79094 ?  151 CYS B N   1 
ATOM   1886 C CA  . CYS B 1 96  ? 0.80466   -26.73327 -39.62548 1.000 18.97553 ?  151 CYS B CA  1 
ATOM   1887 C C   . CYS B 1 96  ? 0.20909   -28.11507 -39.42799 1.000 23.98591 ?  151 CYS B C   1 
ATOM   1888 O O   . CYS B 1 96  ? 0.41687   -28.73219 -38.37823 1.000 24.18746 ?  151 CYS B O   1 
ATOM   1889 C CB  . CYS B 1 96  ? -0.24837  -25.67508 -39.33948 1.000 22.06950 ?  151 CYS B CB  1 
ATOM   1890 S SG  . CYS B 1 96  ? 0.45051   -24.05199 -39.10763 1.000 26.00360 ?  151 CYS B SG  1 
ATOM   1891 N N   . VAL B 1 97  ? -0.53095  -28.60674 -40.42294 1.000 22.57299 ?  152 VAL B N   1 
ATOM   1892 C CA  . VAL B 1 97  ? -1.15486  -29.92041 -40.29917 1.000 27.59168 ?  152 VAL B CA  1 
ATOM   1893 C C   . VAL B 1 97  ? -0.08144  -30.98232 -40.12873 1.000 26.17562 ?  152 VAL B C   1 
ATOM   1894 O O   . VAL B 1 97  ? -0.18187  -31.84479 -39.24989 1.000 27.49220 ?  152 VAL B O   1 
ATOM   1895 C CB  . VAL B 1 97  ? -2.06471  -30.21472 -41.51012 1.000 26.48446 ?  152 VAL B CB  1 
ATOM   1896 C CG1 . VAL B 1 97  ? -2.57697  -31.67363 -41.46714 1.000 28.83216 ?  152 VAL B CG1 1 
ATOM   1897 C CG2 . VAL B 1 97  ? -3.24448  -29.25810 -41.52740 1.000 24.03915 ?  152 VAL B CG2 1 
ATOM   1898 N N   . GLU B 1 98  ? 0.97022   -30.91239 -40.95601 1.000 24.20206 ?  153 GLU B N   1 
ATOM   1899 C CA  . GLU B 1 98  ? 2.10939   -31.82895 -40.84738 1.000 28.64572 ?  153 GLU B CA  1 
ATOM   1900 C C   . GLU B 1 98  ? 2.75429   -31.78113 -39.47274 1.000 29.00935 ?  153 GLU B C   1 
ATOM   1901 O O   . GLU B 1 98  ? 3.12129   -32.82434 -38.91483 1.000 30.16031 ?  153 GLU B O   1 
ATOM   1902 C CB  . GLU B 1 98  ? 3.16126   -31.50552 -41.90023 1.000 33.16117 ?  153 GLU B CB  1 
ATOM   1903 C CG  . GLU B 1 98  ? 2.68633   -31.59207 -43.32906 1.000 37.18563 ?  153 GLU B CG  1 
ATOM   1904 C CD  . GLU B 1 98  ? 3.69952   -30.99647 -44.29466 1.000 47.35995 ?  153 GLU B CD  1 
ATOM   1905 O OE1 . GLU B 1 98  ? 4.79324   -30.57554 -43.82699 1.000 47.84795 ?  153 GLU B OE1 1 
ATOM   1906 O OE2 . GLU B 1 98  ? 3.40014   -30.94620 -45.51133 1.000 48.62615 -1 153 GLU B OE2 1 
ATOM   1907 N N   . SER B 1 99  ? 2.91274   -30.58074 -38.91351 1.000 24.18741 ?  154 SER B N   1 
ATOM   1908 C CA  . SER B 1 99  ? 3.49747   -30.44374 -37.58324 1.000 28.94187 ?  154 SER B CA  1 
ATOM   1909 C C   . SER B 1 99  ? 2.64551   -31.12560 -36.52307 1.000 31.45355 ?  154 SER B C   1 
ATOM   1910 O O   . SER B 1 99  ? 3.17511   -31.79639 -35.62829 1.000 29.46400 ?  154 SER B O   1 
ATOM   1911 C CB  . SER B 1 99  ? 3.67792   -28.96336 -37.23934 1.000 28.89159 ?  154 SER B CB  1 
ATOM   1912 O OG  . SER B 1 99  ? 4.55261   -28.34554 -38.16850 1.000 26.04112 ?  154 SER B OG  1 
ATOM   1913 N N   . VAL B 1 100 ? 1.32325   -30.94274 -36.58410 1.000 27.27842 ?  155 VAL B N   1 
ATOM   1914 C CA  . VAL B 1 100 ? 0.46354   -31.58020 -35.59747 1.000 29.22667 ?  155 VAL B CA  1 
ATOM   1915 C C   . VAL B 1 100 ? 0.42941   -33.08937 -35.82999 1.000 28.49226 ?  155 VAL B C   1 
ATOM   1916 O O   . VAL B 1 100 ? 0.36965   -33.86435 -34.87290 1.000 33.24871 ?  155 VAL B O   1 
ATOM   1917 C CB  . VAL B 1 100 ? -0.94919  -30.95444 -35.61924 1.000 31.77702 ?  155 VAL B CB  1 
ATOM   1918 C CG1 . VAL B 1 100 ? -1.85721  -31.66237 -34.63236 1.000 36.44082 ?  155 VAL B CG1 1 
ATOM   1919 C CG2 . VAL B 1 100 ? -0.88580  -29.46612 -35.26356 1.000 31.20345 ?  155 VAL B CG2 1 
ATOM   1920 N N   . ASP B 1 101 ? 0.50725   -33.52692 -37.09220 1.000 28.46480 ?  156 ASP B N   1 
ATOM   1921 C CA  . ASP B 1 101 ? 0.53373   -34.95289 -37.41396 1.000 30.13432 ?  156 ASP B CA  1 
ATOM   1922 C C   . ASP B 1 101 ? 1.73182   -35.65843 -36.79424 1.000 36.17613 ?  156 ASP B C   1 
ATOM   1923 O O   . ASP B 1 101 ? 1.67184   -36.86679 -36.54442 1.000 33.72501 ?  156 ASP B O   1 
ATOM   1924 C CB  . ASP B 1 101 ? 0.59869   -35.16055 -38.92407 1.000 32.70201 ?  156 ASP B CB  1 
ATOM   1925 C CG  . ASP B 1 101 ? -0.75223  -35.04714 -39.60386 1.000 36.82579 ?  156 ASP B CG  1 
ATOM   1926 O OD1 . ASP B 1 101 ? -1.77883  -34.89030 -38.90121 1.000 41.28896 ?  156 ASP B OD1 1 
ATOM   1927 O OD2 . ASP B 1 101 ? -0.76649  -35.09482 -40.85769 1.000 39.42512 -1 156 ASP B OD2 1 
ATOM   1928 N N   . LYS B 1 102 ? 2.84578   -34.94196 -36.60343 1.000 32.40221 ?  157 LYS B N   1 
ATOM   1929 C CA  . LYS B 1 102 ? 4.07048   -35.50888 -36.06223 1.000 34.32477 ?  157 LYS B CA  1 
ATOM   1930 C C   . LYS B 1 102 ? 4.33663   -35.04744 -34.63247 1.000 34.22725 ?  157 LYS B C   1 
ATOM   1931 O O   . LYS B 1 102 ? 5.48506   -35.03144 -34.18921 1.000 37.37556 ?  157 LYS B O   1 
ATOM   1932 C CB  . LYS B 1 102 ? 5.25298   -35.17296 -36.96170 1.000 35.77676 ?  157 LYS B CB  1 
ATOM   1933 C CG  . LYS B 1 102 ? 5.10371   -35.68065 -38.38533 1.000 38.03001 ?  157 LYS B CG  1 
ATOM   1934 C CD  . LYS B 1 102 ? 6.02777   -34.90502 -39.31826 1.000 48.59362 ?  157 LYS B CD  1 
ATOM   1935 C CE  . LYS B 1 102 ? 5.68516   -35.12862 -40.78670 1.000 53.13125 ?  157 LYS B CE  1 
ATOM   1936 N NZ  . LYS B 1 102 ? 6.69965   -34.50828 -41.68960 1.000 56.11873 ?  157 LYS B NZ  1 
ATOM   1937 N N   . GLU B 1 103 ? 3.28105   -34.68358 -33.90346 1.000 34.18678 ?  158 GLU B N   1 
ATOM   1938 C CA  . GLU B 1 103 ? 3.36264   -34.35486 -32.47901 1.000 37.71633 ?  158 GLU B CA  1 
ATOM   1939 C C   . GLU B 1 103 ? 4.30020   -33.18122 -32.23419 1.000 40.49166 ?  158 GLU B C   1 
ATOM   1940 O O   . GLU B 1 103 ? 5.02713   -33.13204 -31.23723 1.000 38.57255 ?  158 GLU B O   1 
ATOM   1941 C CB  . GLU B 1 103 ? 3.78757   -35.57284 -31.64984 1.000 45.45233 ?  158 GLU B CB  1 
ATOM   1942 C CG  . GLU B 1 103 ? 2.92713   -36.81283 -31.89659 1.000 39.19746 ?  158 GLU B CG  1 
ATOM   1943 C CD  . GLU B 1 103 ? 1.47481   -36.58686 -31.52166 1.000 51.17885 ?  158 GLU B CD  1 
ATOM   1944 O OE1 . GLU B 1 103 ? 0.57815   -37.07382 -32.25981 1.000 47.96477 ?  158 GLU B OE1 1 
ATOM   1945 O OE2 . GLU B 1 103 ? 1.23300   -35.92089 -30.48714 1.000 50.10452 -1 158 GLU B OE2 1 
ATOM   1946 N N   . MET B 1 104 ? 4.29725   -32.23063 -33.16018 1.000 37.19859 ?  159 MET B N   1 
ATOM   1947 C CA  . MET B 1 104 ? 5.05916   -31.01091 -32.95166 1.000 33.38972 ?  159 MET B CA  1 
ATOM   1948 C C   . MET B 1 104 ? 4.12752   -29.82101 -33.06150 1.000 33.22507 ?  159 MET B C   1 
ATOM   1949 O O   . MET B 1 104 ? 4.37581   -28.88899 -33.83473 1.000 27.37587 ?  159 MET B O   1 
ATOM   1950 C CB  . MET B 1 104 ? 6.20930   -30.91999 -33.94415 1.000 32.22799 ?  159 MET B CB  1 
ATOM   1951 C CG  . MET B 1 104 ? 7.35956   -31.80310 -33.51785 1.000 34.37863 ?  159 MET B CG  1 
ATOM   1952 S SD  . MET B 1 104 ? 8.62261   -31.87778 -34.75757 1.000 40.58331 ?  159 MET B SD  1 
ATOM   1953 C CE  . MET B 1 104 ? 7.68381   -31.73386 -36.28629 1.000 34.52167 ?  159 MET B CE  1 
ATOM   1954 N N   . GLN B 1 105 ? 3.05302   -29.87409 -32.27510 1.000 31.56641 ?  160 GLN B N   1 
ATOM   1955 C CA  . GLN B 1 105 ? 2.08305   -28.79090 -32.21078 1.000 35.81688 ?  160 GLN B CA  1 
ATOM   1956 C C   . GLN B 1 105 ? 2.73375   -27.47697 -31.80700 1.000 31.39207 ?  160 GLN B C   1 
ATOM   1957 O O   . GLN B 1 105 ? 2.23720   -26.40726 -32.16897 1.000 31.27284 ?  160 GLN B O   1 
ATOM   1958 C CB  . GLN B 1 105 ? 0.95821   -29.16380 -31.23483 1.000 34.29557 ?  160 GLN B CB  1 
ATOM   1959 C CG  . GLN B 1 105 ? 0.21552   -30.47327 -31.57777 1.000 42.91308 ?  160 GLN B CG  1 
ATOM   1960 C CD  . GLN B 1 105 ? 0.92533   -31.75746 -31.11184 1.000 43.29637 ?  160 GLN B CD  1 
ATOM   1961 O OE1 . GLN B 1 105 ? 2.10734   -31.74987 -30.80506 1.000 43.48036 ?  160 GLN B OE1 1 
ATOM   1962 N NE2 . GLN B 1 105 ? 0.18664   -32.86547 -31.07252 1.000 46.02870 ?  160 GLN B NE2 1 
ATOM   1963 N N   . VAL B 1 106 ? 3.85382   -27.52745 -31.08012 1.000 32.41132 ?  161 VAL B N   1 
ATOM   1964 C CA  . VAL B 1 106 ? 4.52695   -26.29472 -30.68261 1.000 32.17021 ?  161 VAL B CA  1 
ATOM   1965 C C   . VAL B 1 106 ? 4.94684   -25.47074 -31.90344 1.000 31.64524 ?  161 VAL B C   1 
ATOM   1966 O O   . VAL B 1 106 ? 5.07462   -24.24491 -31.81912 1.000 29.08578 ?  161 VAL B O   1 
ATOM   1967 C CB  . VAL B 1 106 ? 5.73265   -26.64691 -29.76440 1.000 32.97990 ?  161 VAL B CB  1 
ATOM   1968 C CG1 . VAL B 1 106 ? 6.64399   -27.66428 -30.43948 1.000 28.13945 ?  161 VAL B CG1 1 
ATOM   1969 C CG2 . VAL B 1 106 ? 6.50630   -25.41764 -29.37333 1.000 32.23080 ?  161 VAL B CG2 1 
ATOM   1970 N N   . LEU B 1 107 ? 5.13729   -26.11085 -33.05406 1.000 26.83688 ?  162 LEU B N   1 
ATOM   1971 C CA  . LEU B 1 107 ? 5.56989   -25.39624 -34.24794 1.000 28.29597 ?  162 LEU B CA  1 
ATOM   1972 C C   . LEU B 1 107 ? 4.48076   -24.53370 -34.88566 1.000 23.83107 ?  162 LEU B C   1 
ATOM   1973 O O   . LEU B 1 107 ? 4.81395   -23.67323 -35.70822 1.000 22.34533 ?  162 LEU B O   1 
ATOM   1974 C CB  . LEU B 1 107 ? 6.08846   -26.39590 -35.27917 1.000 28.70034 ?  162 LEU B CB  1 
ATOM   1975 C CG  . LEU B 1 107 ? 7.46228   -26.97711 -34.94109 1.000 30.17285 ?  162 LEU B CG  1 
ATOM   1976 C CD1 . LEU B 1 107 ? 7.92220   -27.90041 -36.05997 1.000 34.58890 ?  162 LEU B CD1 1 
ATOM   1977 C CD2 . LEU B 1 107 ? 8.44996   -25.83810 -34.72296 1.000 29.87651 ?  162 LEU B CD2 1 
ATOM   1978 N N   . VAL B 1 108 ? 3.21024   -24.73835 -34.53231 1.000 21.77109 ?  163 VAL B N   1 
ATOM   1979 C CA  . VAL B 1 108 ? 2.11889   -24.02619 -35.20319 1.000 29.16384 ?  163 VAL B CA  1 
ATOM   1980 C C   . VAL B 1 108 ? 2.24773   -22.51422 -35.00687 1.000 26.99304 ?  163 VAL B C   1 
ATOM   1981 O O   . VAL B 1 108 ? 2.14700   -21.74010 -35.96686 1.000 26.37578 ?  163 VAL B O   1 
ATOM   1982 C CB  . VAL B 1 108 ? 0.75084   -24.55407 -34.72678 1.000 25.74118 ?  163 VAL B CB  1 
ATOM   1983 C CG1 . VAL B 1 108 ? -0.36528  -23.69763 -35.29153 1.000 23.30859 ?  163 VAL B CG1 1 
ATOM   1984 C CG2 . VAL B 1 108 ? 0.57453   -26.00642 -35.17126 1.000 21.41795 ?  163 VAL B CG2 1 
ATOM   1985 N N   . SER B 1 109 ? 2.50782   -22.06563 -33.77376 1.000 27.77790 ?  164 SER B N   1 
ATOM   1986 C CA  . SER B 1 109 ? 2.59897   -20.61910 -33.53956 1.000 25.72307 ?  164 SER B CA  1 
ATOM   1987 C C   . SER B 1 109 ? 3.84634   -20.01322 -34.17428 1.000 26.75286 ?  164 SER B C   1 
ATOM   1988 O O   . SER B 1 109 ? 3.84544   -18.82996 -34.53289 1.000 23.97287 ?  164 SER B O   1 
ATOM   1989 C CB  . SER B 1 109 ? 2.55987   -20.31828 -32.04151 1.000 33.17596 ?  164 SER B CB  1 
ATOM   1990 O OG  . SER B 1 109 ? 3.49001   -21.13333 -31.35132 1.000 42.26117 ?  164 SER B OG  1 
ATOM   1991 N N   . ARG B 1 110 ? 4.90996   -20.80812 -34.34795 1.000 23.75049 ?  165 ARG B N   1 
ATOM   1992 C CA  . ARG B 1 110 ? 6.06879   -20.34435 -35.09056 1.000 25.53068 ?  165 ARG B CA  1 
ATOM   1993 C C   . ARG B 1 110 ? 5.74673   -20.17354 -36.56387 1.000 23.25595 ?  165 ARG B C   1 
ATOM   1994 O O   . ARG B 1 110 ? 6.20102   -19.21226 -37.19046 1.000 22.05388 ?  165 ARG B O   1 
ATOM   1995 C CB  . ARG B 1 110 ? 7.22978   -21.32876 -34.92191 1.000 29.75184 ?  165 ARG B CB  1 
ATOM   1996 C CG  . ARG B 1 110 ? 8.42383   -21.03573 -35.79712 1.000 28.31605 ?  165 ARG B CG  1 
ATOM   1997 C CD  . ARG B 1 110 ? 9.63819   -21.89817 -35.40358 1.000 29.95522 ?  165 ARG B CD  1 
ATOM   1998 N NE  . ARG B 1 110 ? 10.16654  -21.49063 -34.10297 1.000 38.90733 ?  165 ARG B NE  1 
ATOM   1999 C CZ  . ARG B 1 110 ? 10.97887  -22.22645 -33.34741 1.000 40.01625 ?  165 ARG B CZ  1 
ATOM   2000 N NH1 . ARG B 1 110 ? 11.37414  -23.43380 -33.75348 1.000 37.18992 ?  165 ARG B NH1 1 
ATOM   2001 N NH2 . ARG B 1 110 ? 11.39607  -21.74578 -32.17973 1.000 41.81071 ?  165 ARG B NH2 1 
ATOM   2002 N N   . ILE B 1 111 ? 5.01219   -21.12960 -37.14537 1.000 21.55825 ?  166 ILE B N   1 
ATOM   2003 C CA  . ILE B 1 111 ? 4.60322   -21.01034 -38.54205 1.000 23.60233 ?  166 ILE B CA  1 
ATOM   2004 C C   . ILE B 1 111 ? 3.70990   -19.78184 -38.72028 1.000 18.47838 ?  166 ILE B C   1 
ATOM   2005 O O   . ILE B 1 111 ? 3.86566   -19.02594 -39.67911 1.000 21.63788 ?  166 ILE B O   1 
ATOM   2006 C CB  . ILE B 1 111 ? 3.90144   -22.30525 -39.01940 1.000 18.64492 ?  166 ILE B CB  1 
ATOM   2007 C CG1 . ILE B 1 111 ? 4.90366   -23.47565 -39.10444 1.000 20.99903 ?  166 ILE B CG1 1 
ATOM   2008 C CG2 . ILE B 1 111 ? 3.27092   -22.11168 -40.40977 1.000 17.33117 ?  166 ILE B CG2 1 
ATOM   2009 C CD1 . ILE B 1 111 ? 4.22813   -24.87010 -39.03408 1.000 22.79945 ?  166 ILE B CD1 1 
ATOM   2010 N N   . ALA B 1 112 ? 2.77304   -19.55712 -37.79286 1.000 16.08610 ?  167 ALA B N   1 
ATOM   2011 C CA  . ALA B 1 112 ? 1.93155   -18.36165 -37.87366 1.000 20.18173 ?  167 ALA B CA  1 
ATOM   2012 C C   . ALA B 1 112 ? 2.76910   -17.08255 -37.83980 1.000 19.69898 ?  167 ALA B C   1 
ATOM   2013 O O   . ALA B 1 112 ? 2.49790   -16.13407 -38.58585 1.000 19.16396 ?  167 ALA B O   1 
ATOM   2014 C CB  . ALA B 1 112 ? 0.90100   -18.36905 -36.74244 1.000 22.76605 ?  167 ALA B CB  1 
ATOM   2015 N N   . ALA B 1 113 ? 3.80543   -17.03886 -36.98881 1.000 17.98088 ?  168 ALA B N   1 
ATOM   2016 C CA  . ALA B 1 113 ? 4.66262   -15.86157 -36.92892 1.000 19.81542 ?  168 ALA B CA  1 
ATOM   2017 C C   . ALA B 1 113 ? 5.46684   -15.69417 -38.20950 1.000 20.97799 ?  168 ALA B C   1 
ATOM   2018 O O   . ALA B 1 113 ? 5.68223   -14.56786 -38.67220 1.000 22.71960 ?  168 ALA B O   1 
ATOM   2019 C CB  . ALA B 1 113 ? 5.60788   -15.96074 -35.72313 1.000 22.95383 ?  168 ALA B CB  1 
ATOM   2020 N N   . TRP B 1 114 ? 5.95736   -16.79645 -38.78077 1.000 17.75156 ?  169 TRP B N   1 
ATOM   2021 C CA  . TRP B 1 114 ? 6.64125   -16.70399 -40.06502 1.000 19.10879 ?  169 TRP B CA  1 
ATOM   2022 C C   . TRP B 1 114 ? 5.71486   -16.12000 -41.11558 1.000 21.16885 ?  169 TRP B C   1 
ATOM   2023 O O   . TRP B 1 114 ? 6.11583   -15.25660 -41.90308 1.000 20.24102 ?  169 TRP B O   1 
ATOM   2024 C CB  . TRP B 1 114 ? 7.11635   -18.08058 -40.53100 1.000 20.06123 ?  169 TRP B CB  1 
ATOM   2025 C CG  . TRP B 1 114 ? 8.25931   -18.67787 -39.77768 1.000 23.24963 ?  169 TRP B CG  1 
ATOM   2026 C CD1 . TRP B 1 114 ? 9.03419   -18.08012 -38.83601 1.000 24.75479 ?  169 TRP B CD1 1 
ATOM   2027 C CD2 . TRP B 1 114 ? 8.73902   -20.02097 -39.90582 1.000 24.06604 ?  169 TRP B CD2 1 
ATOM   2028 N NE1 . TRP B 1 114 ? 9.98184   -18.96575 -38.37274 1.000 24.68913 ?  169 TRP B NE1 1 
ATOM   2029 C CE2 . TRP B 1 114 ? 9.82384   -20.16454 -39.01479 1.000 27.04383 ?  169 TRP B CE2 1 
ATOM   2030 C CE3 . TRP B 1 114 ? 8.35206   -21.11271 -40.68675 1.000 23.42140 ?  169 TRP B CE3 1 
ATOM   2031 C CZ2 . TRP B 1 114 ? 10.54620  -21.36382 -38.88920 1.000 28.89189 ?  169 TRP B CZ2 1 
ATOM   2032 C CZ3 . TRP B 1 114 ? 9.07077   -22.30750 -40.56486 1.000 31.88730 ?  169 TRP B CZ3 1 
ATOM   2033 C CH2 . TRP B 1 114 ? 10.14754  -22.42096 -39.66719 1.000 27.23386 ?  169 TRP B CH2 1 
ATOM   2034 N N   . MET B 1 115 ? 4.48763   -16.63510 -41.18567 1.000 20.12949 ?  170 MET B N   1 
ATOM   2035 C CA  . MET B 1 115 ? 3.57097   -16.18467 -42.22725 1.000 18.20648 ?  170 MET B CA  1 
ATOM   2036 C C   . MET B 1 115 ? 3.23114   -14.70973 -42.04874 1.000 21.79404 ?  170 MET B C   1 
ATOM   2037 O O   . MET B 1 115 ? 3.21952   -13.94920 -43.02350 1.000 19.80362 ?  170 MET B O   1 
ATOM   2038 C CB  . MET B 1 115 ? 2.31518   -17.03268 -42.21566 1.000 16.82395 ?  170 MET B CB  1 
ATOM   2039 C CG  . MET B 1 115 ? 2.55083   -18.48130 -42.67234 1.000 17.80226 ?  170 MET B CG  1 
ATOM   2040 S SD  . MET B 1 115 ? 1.04849   -19.42057 -42.36834 1.000 22.70566 ?  170 MET B SD  1 
ATOM   2041 C CE  . MET B 1 115 ? -0.03199  -18.80316 -43.63978 1.000 20.84310 ?  170 MET B CE  1 
ATOM   2042 N N   . ALA B 1 116 ? 2.97580   -14.28304 -40.80713 1.000 18.47927 ?  171 ALA B N   1 
ATOM   2043 C CA  . ALA B 1 116 ? 2.67303   -12.87200 -40.56066 1.000 19.60926 ?  171 ALA B CA  1 
ATOM   2044 C C   . ALA B 1 116 ? 3.84997   -11.99053 -40.93044 1.000 26.22594 ?  171 ALA B C   1 
ATOM   2045 O O   . ALA B 1 116 ? 3.66915   -10.93602 -41.55453 1.000 24.51679 ?  171 ALA B O   1 
ATOM   2046 C CB  . ALA B 1 116 ? 2.27660   -12.66448 -39.09384 1.000 21.00604 ?  171 ALA B CB  1 
ATOM   2047 N N   . THR B 1 117 ? 5.07152   -12.43354 -40.57802 1.000 21.90920 ?  172 THR B N   1 
ATOM   2048 C CA  . THR B 1 117 ? 6.28825   -11.70122 -40.90549 1.000 25.87479 ?  172 THR B CA  1 
ATOM   2049 C C   . THR B 1 117 ? 6.47145   -11.59777 -42.40442 1.000 25.89572 ?  172 THR B C   1 
ATOM   2050 O O   . THR B 1 117 ? 6.84607   -10.53672 -42.92151 1.000 25.90193 ?  172 THR B O   1 
ATOM   2051 C CB  . THR B 1 117 ? 7.51599   -12.39077 -40.28446 1.000 23.97356 ?  172 THR B CB  1 
ATOM   2052 O OG1 . THR B 1 117 ? 7.44432   -12.31574 -38.86083 1.000 24.17710 ?  172 THR B OG1 1 
ATOM   2053 C CG2 . THR B 1 117 ? 8.83364   -11.74219 -40.76678 1.000 26.20130 ?  172 THR B CG2 1 
ATOM   2054 N N   . TYR B 1 118 ? 6.24053   -12.69201 -43.12488 1.000 19.30631 ?  173 TYR B N   1 
ATOM   2055 C CA  . TYR B 1 118 ? 6.45360   -12.62801 -44.56482 1.000 25.27606 ?  173 TYR B CA  1 
ATOM   2056 C C   . TYR B 1 118 ? 5.44450   -11.68233 -45.20826 1.000 26.88944 ?  173 TYR B C   1 
ATOM   2057 O O   . TYR B 1 118 ? 5.80819   -10.86612 -46.06829 1.000 26.76674 ?  173 TYR B O   1 
ATOM   2058 C CB  . TYR B 1 118 ? 6.38497   -14.02393 -45.19922 1.000 21.11319 ?  173 TYR B CB  1 
ATOM   2059 C CG  . TYR B 1 118 ? 6.88397   -14.02128 -46.63318 1.000 26.27032 ?  173 TYR B CG  1 
ATOM   2060 C CD1 . TYR B 1 118 ? 6.04368   -13.64724 -47.67883 1.000 25.16134 ?  173 TYR B CD1 1 
ATOM   2061 C CD2 . TYR B 1 118 ? 8.20117   -14.34906 -46.93781 1.000 24.16470 ?  173 TYR B CD2 1 
ATOM   2062 C CE1 . TYR B 1 118 ? 6.49133   -13.60392 -48.99037 1.000 23.26671 ?  173 TYR B CE1 1 
ATOM   2063 C CE2 . TYR B 1 118 ? 8.65559   -14.30821 -48.24616 1.000 22.74952 ?  173 TYR B CE2 1 
ATOM   2064 C CZ  . TYR B 1 118 ? 7.79691   -13.93564 -49.25769 1.000 24.62558 ?  173 TYR B CZ  1 
ATOM   2065 O OH  . TYR B 1 118 ? 8.23189   -13.89174 -50.55095 1.000 25.75650 ?  173 TYR B OH  1 
ATOM   2066 N N   . LEU B 1 119 ? 4.17779   -11.77320 -44.78658 1.000 24.66573 ?  174 LEU B N   1 
ATOM   2067 C CA  . LEU B 1 119 ? 3.14269   -10.86107 -45.27436 1.000 23.76643 ?  174 LEU B CA  1 
ATOM   2068 C C   . LEU B 1 119 ? 3.51206   -9.40652  -44.99302 1.000 26.19515 ?  174 LEU B C   1 
ATOM   2069 O O   . LEU B 1 119 ? 3.48253   -8.56756  -45.89546 1.000 28.19605 ?  174 LEU B O   1 
ATOM   2070 C CB  . LEU B 1 119 ? 1.79807   -11.20589 -44.63151 1.000 23.92334 ?  174 LEU B CB  1 
ATOM   2071 C CG  . LEU B 1 119 ? 0.97832   -12.36234 -45.20470 1.000 24.15959 ?  174 LEU B CG  1 
ATOM   2072 C CD1 . LEU B 1 119 ? -0.03131  -12.81001 -44.18042 1.000 24.21432 ?  174 LEU B CD1 1 
ATOM   2073 C CD2 . LEU B 1 119 ? 0.24751   -11.90736 -46.45651 1.000 25.54518 ?  174 LEU B CD2 1 
ATOM   2074 N N   . ASN B 1 120 ? 3.86941   -9.09428  -43.74203 1.000 27.78878 ?  175 ASN B N   1 
ATOM   2075 C CA  . ASN B 1 120 ? 4.18043   -7.71402  -43.36706 1.000 32.59503 ?  175 ASN B CA  1 
ATOM   2076 C C   . ASN B 1 120 ? 5.42139   -7.19549  -44.08955 1.000 31.29083 ?  175 ASN B C   1 
ATOM   2077 O O   . ASN B 1 120 ? 5.45041   -6.03646  -44.51978 1.000 31.38809 ?  175 ASN B O   1 
ATOM   2078 C CB  . ASN B 1 120 ? 4.38097   -7.60088  -41.85582 1.000 29.51072 ?  175 ASN B CB  1 
ATOM   2079 C CG  . ASN B 1 120 ? 3.10799   -7.81478  -41.06760 1.000 32.88653 ?  175 ASN B CG  1 
ATOM   2080 O OD1 . ASN B 1 120 ? 1.99630   -7.53560  -41.53861 1.000 38.46736 ?  175 ASN B OD1 1 
ATOM   2081 N ND2 . ASN B 1 120 ? 3.26402   -8.29035  -39.83932 1.000 37.72006 ?  175 ASN B ND2 1 
ATOM   2082 N N   . ASP B 1 121 ? 6.46079   -8.02777  -44.23243 1.000 27.05065 ?  176 ASP B N   1 
ATOM   2083 C CA  . ASP B 1 121 ? 7.71557   -7.54511  -44.81127 1.000 28.94764 ?  176 ASP B CA  1 
ATOM   2084 C C   . ASP B 1 121 ? 7.71821   -7.60421  -46.33793 1.000 33.21558 ?  176 ASP B C   1 
ATOM   2085 O O   . ASP B 1 121 ? 8.29832   -6.73057  -46.98955 1.000 35.15805 ?  176 ASP B O   1 
ATOM   2086 C CB  . ASP B 1 121 ? 8.90969   -8.35072  -44.27846 1.000 32.21525 ?  176 ASP B CB  1 
ATOM   2087 C CG  . ASP B 1 121 ? 9.14583   -8.15771  -42.78577 1.000 34.90972 ?  176 ASP B CG  1 
ATOM   2088 O OD1 . ASP B 1 121 ? 8.39629   -7.38902  -42.13569 1.000 31.83179 ?  176 ASP B OD1 1 
ATOM   2089 O OD2 . ASP B 1 121 ? 10.09069  -8.79898  -42.26766 1.000 35.74043 -1 176 ASP B OD2 1 
ATOM   2090 N N   . HIS B 1 122 ? 7.12169   -8.63773  -46.93262 1.000 27.87968 ?  177 HIS B N   1 
ATOM   2091 C CA  . HIS B 1 122 ? 7.30988   -8.91942  -48.35020 1.000 27.47470 ?  177 HIS B CA  1 
ATOM   2092 C C   . HIS B 1 122 ? 6.07298   -8.69775  -49.21069 1.000 28.35923 ?  177 HIS B C   1 
ATOM   2093 O O   . HIS B 1 122 ? 6.21499   -8.43545  -50.39880 1.000 31.12350 ?  177 HIS B O   1 
ATOM   2094 C CB  . HIS B 1 122 ? 7.75890   -10.37390 -48.55317 1.000 27.71224 ?  177 HIS B CB  1 
ATOM   2095 C CG  . HIS B 1 122 ? 9.14063   -10.67689 -48.05523 1.000 31.42950 ?  177 HIS B CG  1 
ATOM   2096 N ND1 . HIS B 1 122 ? 10.17413  -11.00864 -48.90164 1.000 34.13270 ?  177 HIS B ND1 1 
ATOM   2097 C CD2 . HIS B 1 122 ? 9.64552   -10.74726 -46.79996 1.000 31.19807 ?  177 HIS B CD2 1 
ATOM   2098 C CE1 . HIS B 1 122 ? 11.26598  -11.23855 -48.19229 1.000 33.55036 ?  177 HIS B CE1 1 
ATOM   2099 N NE2 . HIS B 1 122 ? 10.97373  -11.08012 -46.91521 1.000 35.71837 ?  177 HIS B NE2 1 
ATOM   2100 N N   . LEU B 1 123 ? 4.86985   -8.82686  -48.65832 1.000 27.58495 ?  178 LEU B N   1 
ATOM   2101 C CA  . LEU B 1 123 ? 3.63898   -8.78587  -49.43622 1.000 29.94310 ?  178 LEU B CA  1 
ATOM   2102 C C   . LEU B 1 123 ? 2.79874   -7.53617  -49.20289 1.000 32.34159 ?  178 LEU B C   1 
ATOM   2103 O O   . LEU B 1 123 ? 2.04931   -7.13790  -50.10117 1.000 28.72259 ?  178 LEU B O   1 
ATOM   2104 C CB  . LEU B 1 123 ? 2.78122   -10.02996 -49.13224 1.000 25.67347 ?  178 LEU B CB  1 
ATOM   2105 C CG  . LEU B 1 123 ? 3.39601   -11.34140 -49.64055 1.000 26.36186 ?  178 LEU B CG  1 
ATOM   2106 C CD1 . LEU B 1 123 ? 2.51891   -12.55987 -49.31606 1.000 24.47779 ?  178 LEU B CD1 1 
ATOM   2107 C CD2 . LEU B 1 123 ? 3.66693   -11.25288 -51.14360 1.000 28.20425 ?  178 LEU B CD2 1 
ATOM   2108 N N   . GLU B 1 124 ? 2.89533   -6.92519  -48.02214 1.000 31.98471 ?  179 GLU B N   1 
ATOM   2109 C CA  . GLU B 1 124 ? 2.08430   -5.74982  -47.69986 1.000 34.41113 ?  179 GLU B CA  1 
ATOM   2110 C C   . GLU B 1 124 ? 2.21796   -4.61425  -48.71099 1.000 34.59758 ?  179 GLU B C   1 
ATOM   2111 O O   . GLU B 1 124 ? 1.18847   -4.00865  -49.04344 1.000 32.21476 ?  179 GLU B O   1 
ATOM   2112 C CB  . GLU B 1 124 ? 2.44151   -5.25544  -46.28821 1.000 31.89814 ?  179 GLU B CB  1 
ATOM   2113 C CG  . GLU B 1 124 ? 1.47597   -4.22893  -45.71221 1.000 36.93697 ?  179 GLU B CG  1 
ATOM   2114 C CD  . GLU B 1 124 ? 0.03680   -4.73167  -45.67050 1.000 40.82903 ?  179 GLU B CD  1 
ATOM   2115 O OE1 . GLU B 1 124 ? -0.18773  -5.91296  -45.32712 1.000 45.63485 ?  179 GLU B OE1 1 
ATOM   2116 O OE2 . GLU B 1 124 ? -0.87493  -3.94759  -46.00174 1.000 44.16546 -1 179 GLU B OE2 1 
ATOM   2117 N N   . PRO B 1 125 ? 3.40491   -4.26419  -49.22579 1.000 33.87182 ?  180 PRO B N   1 
ATOM   2118 C CA  . PRO B 1 125 ? 3.44402   -3.20490  -50.25178 1.000 33.82248 ?  180 PRO B CA  1 
ATOM   2119 C C   . PRO B 1 125 ? 2.59757   -3.51567  -51.47221 1.000 35.77645 ?  180 PRO B C   1 
ATOM   2120 O O   . PRO B 1 125 ? 1.92514   -2.61846  -51.99000 1.000 35.11945 ?  180 PRO B O   1 
ATOM   2121 C CB  . PRO B 1 125 ? 4.93481   -3.10967  -50.60197 1.000 33.12252 ?  180 PRO B CB  1 
ATOM   2122 C CG  . PRO B 1 125 ? 5.63630   -3.54296  -49.36011 1.000 37.16972 ?  180 PRO B CG  1 
ATOM   2123 C CD  . PRO B 1 125 ? 4.75976   -4.61604  -48.75047 1.000 37.79198 ?  180 PRO B CD  1 
ATOM   2124 N N   . TRP B 1 126 ? 2.62281   -4.76229  -51.95643 1.000 35.33894 ?  181 TRP B N   1 
ATOM   2125 C CA  . TRP B 1 126 ? 1.80215   -5.13248  -53.10375 1.000 30.68168 ?  181 TRP B CA  1 
ATOM   2126 C C   . TRP B 1 126 ? 0.32565   -5.15708  -52.73372 1.000 32.39108 ?  181 TRP B C   1 
ATOM   2127 O O   . TRP B 1 126 ? -0.52222  -4.67916  -53.49903 1.000 30.17015 ?  181 TRP B O   1 
ATOM   2128 C CB  . TRP B 1 126 ? 2.24344   -6.49546  -53.64550 1.000 29.29254 ?  181 TRP B CB  1 
ATOM   2129 C CG  . TRP B 1 126 ? 1.50539   -6.91029  -54.87917 1.000 26.67871 ?  181 TRP B CG  1 
ATOM   2130 C CD1 . TRP B 1 126 ? 1.89629   -6.71251  -56.16496 1.000 30.14079 ?  181 TRP B CD1 1 
ATOM   2131 C CD2 . TRP B 1 126 ? 0.25584   -7.60024  -54.94157 1.000 25.67713 ?  181 TRP B CD2 1 
ATOM   2132 N NE1 . TRP B 1 126 ? 0.96603   -7.22741  -57.02656 1.000 27.67953 ?  181 TRP B NE1 1 
ATOM   2133 C CE2 . TRP B 1 126 ? -0.05344  -7.78013  -56.29971 1.000 28.66849 ?  181 TRP B CE2 1 
ATOM   2134 C CE3 . TRP B 1 126 ? -0.63562  -8.08470  -53.97632 1.000 26.18880 ?  181 TRP B CE3 1 
ATOM   2135 C CZ2 . TRP B 1 126 ? -1.22260  -8.41641  -56.72805 1.000 30.74566 ?  181 TRP B CZ2 1 
ATOM   2136 C CZ3 . TRP B 1 126 ? -1.79076  -8.72072  -54.39791 1.000 26.73160 ?  181 TRP B CZ3 1 
ATOM   2137 C CH2 . TRP B 1 126 ? -2.07411  -8.87918  -55.76540 1.000 30.20527 ?  181 TRP B CH2 1 
ATOM   2138 N N   . ILE B 1 127 ? -0.00259  -5.71216  -51.56595 1.000 26.89412 ?  182 ILE B N   1 
ATOM   2139 C CA  . ILE B 1 127 ? -1.39863  -5.77837  -51.14397 1.000 29.44729 ?  182 ILE B CA  1 
ATOM   2140 C C   . ILE B 1 127 ? -1.99926  -4.37320  -51.07186 1.000 32.34806 ?  182 ILE B C   1 
ATOM   2141 O O   . ILE B 1 127 ? -3.06172  -4.10286  -51.64498 1.000 30.39342 ?  182 ILE B O   1 
ATOM   2142 C CB  . ILE B 1 127 ? -1.51633  -6.52169  -49.80179 1.000 28.75914 ?  182 ILE B CB  1 
ATOM   2143 C CG1 . ILE B 1 127 ? -1.23057  -8.02710  -49.98976 1.000 29.53179 ?  182 ILE B CG1 1 
ATOM   2144 C CG2 . ILE B 1 127 ? -2.91732  -6.32762  -49.21645 1.000 27.95995 ?  182 ILE B CG2 1 
ATOM   2145 C CD1 . ILE B 1 127 ? -1.13882  -8.80299  -48.66714 1.000 26.24768 ?  182 ILE B CD1 1 
ATOM   2146 N N   . GLN B 1 128 ? -1.31408  -3.45492  -50.37578 1.000 32.14888 ?  183 GLN B N   1 
ATOM   2147 C CA  . GLN B 1 128 ? -1.79908  -2.07945  -50.26869 1.000 34.27321 ?  183 GLN B CA  1 
ATOM   2148 C C   . GLN B 1 128 ? -1.82946  -1.39193  -51.62556 1.000 35.37837 ?  183 GLN B C   1 
ATOM   2149 O O   . GLN B 1 128 ? -2.80121  -0.70206  -51.95513 1.000 36.92190 ?  183 GLN B O   1 
ATOM   2150 C CB  . GLN B 1 128 ? -0.93689  -1.28810  -49.29085 1.000 35.21549 ?  183 GLN B CB  1 
ATOM   2151 C CG  . GLN B 1 128 ? -1.17625  -1.68133  -47.83331 1.000 37.38528 ?  183 GLN B CG  1 
ATOM   2152 C CD  . GLN B 1 128 ? -2.66105  -1.73107  -47.48344 1.000 44.42381 ?  183 GLN B CD  1 
ATOM   2153 O OE1 . GLN B 1 128 ? -3.36204  -0.73996  -47.62965 1.000 48.16194 ?  183 GLN B OE1 1 
ATOM   2154 N NE2 . GLN B 1 128 ? -3.14740  -2.89750  -47.04858 1.000 42.08573 ?  183 GLN B NE2 1 
ATOM   2155 N N   . GLU B 1 129 ? -0.79191  -1.58879  -52.43991 1.000 31.55089 ?  184 GLU B N   1 
ATOM   2156 C CA  . GLU B 1 129 ? -0.80206  -1.01959  -53.78290 1.000 35.80831 ?  184 GLU B CA  1 
ATOM   2157 C C   . GLU B 1 129 ? -2.02269  -1.47500  -54.57393 1.000 39.34061 ?  184 GLU B C   1 
ATOM   2158 O O   . GLU B 1 129 ? -2.57889  -0.69764  -55.36135 1.000 35.96935 ?  184 GLU B O   1 
ATOM   2159 C CB  . GLU B 1 129 ? 0.48894   -1.38814  -54.51885 1.000 38.77095 ?  184 GLU B CB  1 
ATOM   2160 C CG  . GLU B 1 129 ? 0.29074   -1.68908  -55.99689 1.000 44.94146 ?  184 GLU B CG  1 
ATOM   2161 C CD  . GLU B 1 129 ? 1.59743   -1.84823  -56.76569 1.000 51.14573 ?  184 GLU B CD  1 
ATOM   2162 O OE1 . GLU B 1 129 ? 2.42494   -2.71659  -56.39353 1.000 53.86059 ?  184 GLU B OE1 1 
ATOM   2163 O OE2 . GLU B 1 129 ? 1.79982   -1.08719  -57.74319 1.000 56.08324 -1 184 GLU B OE2 1 
ATOM   2164 N N   . ASN B 1 130 ? -2.48220  -2.70935  -54.34665 1.000 32.89128 ?  185 ASN B N   1 
ATOM   2165 C CA  . ASN B 1 130 ? -3.57069  -3.30083  -55.10948 1.000 34.26716 ?  185 ASN B CA  1 
ATOM   2166 C C   . ASN B 1 130 ? -4.92139  -3.15771  -54.43732 1.000 34.03354 ?  185 ASN B C   1 
ATOM   2167 O O   . ASN B 1 130 ? -5.82272  -3.94015  -54.73678 1.000 33.88523 ?  185 ASN B O   1 
ATOM   2168 C CB  . ASN B 1 130 ? -3.30320  -4.77946  -55.36045 1.000 33.47367 ?  185 ASN B CB  1 
ATOM   2169 C CG  . ASN B 1 130 ? -2.44267  -4.99830  -56.54464 1.000 34.71253 ?  185 ASN B CG  1 
ATOM   2170 O OD1 . ASN B 1 130 ? -1.23377  -4.74741  -56.50654 1.000 37.05917 ?  185 ASN B OD1 1 
ATOM   2171 N ND2 . ASN B 1 130 ? -3.05265  -5.44689  -57.62820 1.000 37.32492 ?  185 ASN B ND2 1 
ATOM   2172 N N   . GLY B 1 131 ? -5.07411  -2.20517  -53.52129 1.000 34.75646 ?  186 GLY B N   1 
ATOM   2173 C CA  . GLY B 1 131 ? -6.35568  -1.93878  -52.91625 1.000 36.52686 ?  186 GLY B CA  1 
ATOM   2174 C C   . GLY B 1 131 ? -6.60508  -2.57832  -51.56923 1.000 38.31142 ?  186 GLY B C   1 
ATOM   2175 O O   . GLY B 1 131 ? -7.70438  -2.41328  -51.02653 1.000 33.45832 ?  186 GLY B O   1 
ATOM   2176 N N   . GLY B 1 132 ? -5.62915  -3.28867  -51.00158 1.000 37.16147 ?  187 GLY B N   1 
ATOM   2177 C CA  . GLY B 1 132 ? -5.83799  -3.91785  -49.71523 1.000 30.87364 ?  187 GLY B CA  1 
ATOM   2178 C C   . GLY B 1 132 ? -6.63406  -5.19719  -49.83608 1.000 30.96079 ?  187 GLY B C   1 
ATOM   2179 O O   . GLY B 1 132 ? -7.04869  -5.62356  -50.92133 1.000 31.62989 ?  187 GLY B O   1 
ATOM   2180 N N   . TRP B 1 133 ? -6.84978  -5.82981  -48.67700 1.000 29.58606 ?  188 TRP B N   1 
ATOM   2181 C CA  . TRP B 1 133 ? -7.61061  -7.07508  -48.65144 1.000 31.41785 ?  188 TRP B CA  1 
ATOM   2182 C C   . TRP B 1 133 ? -9.05225  -6.86549  -49.08867 1.000 33.28762 ?  188 TRP B C   1 
ATOM   2183 O O   . TRP B 1 133 ? -9.68664  -7.80419  -49.58574 1.000 30.23234 ?  188 TRP B O   1 
ATOM   2184 C CB  . TRP B 1 133 ? -7.56473  -7.70425  -47.25596 1.000 30.41308 ?  188 TRP B CB  1 
ATOM   2185 C CG  . TRP B 1 133 ? -6.29497  -8.47751  -47.02526 1.000 31.10013 ?  188 TRP B CG  1 
ATOM   2186 C CD1 . TRP B 1 133 ? -5.26363  -8.12675  -46.20736 1.000 31.33170 ?  188 TRP B CD1 1 
ATOM   2187 C CD2 . TRP B 1 133 ? -5.91711  -9.71254  -47.64217 1.000 27.34643 ?  188 TRP B CD2 1 
ATOM   2188 N NE1 . TRP B 1 133 ? -4.26738  -9.07044  -46.26908 1.000 27.87588 ?  188 TRP B NE1 1 
ATOM   2189 C CE2 . TRP B 1 133 ? -4.64571  -10.05827 -47.13851 1.000 32.59601 ?  188 TRP B CE2 1 
ATOM   2190 C CE3 . TRP B 1 133 ? -6.53687  -10.56886 -48.56274 1.000 28.22433 ?  188 TRP B CE3 1 
ATOM   2191 C CZ2 . TRP B 1 133 ? -3.98117  -11.22492 -47.52089 1.000 25.52995 ?  188 TRP B CZ2 1 
ATOM   2192 C CZ3 . TRP B 1 133 ? -5.88400  -11.72340 -48.94156 1.000 28.80707 ?  188 TRP B CZ3 1 
ATOM   2193 C CH2 . TRP B 1 133 ? -4.61346  -12.04029 -48.42704 1.000 29.97462 ?  188 TRP B CH2 1 
ATOM   2194 N N   . ASP B 1 134 ? -9.59387  -5.65331  -48.90153 1.000 32.67782 ?  189 ASP B N   1 
ATOM   2195 C CA  . ASP B 1 134 ? -10.95699 -5.38713  -49.35250 1.000 32.26946 ?  189 ASP B CA  1 
ATOM   2196 C C   . ASP B 1 134 ? -11.09034 -5.60539  -50.85275 1.000 33.35457 ?  189 ASP B C   1 
ATOM   2197 O O   . ASP B 1 134 ? -12.14160 -6.04654  -51.32510 1.000 32.33486 ?  189 ASP B O   1 
ATOM   2198 C CB  . ASP B 1 134 ? -11.37635 -3.95839  -48.98334 1.000 38.48682 ?  189 ASP B CB  1 
ATOM   2199 C CG  . ASP B 1 134 ? -11.75692 -3.81011  -47.50583 1.000 45.54556 ?  189 ASP B CG  1 
ATOM   2200 O OD1 . ASP B 1 134 ? -11.79267 -4.82705  -46.77125 1.000 42.84988 ?  189 ASP B OD1 1 
ATOM   2201 O OD2 . ASP B 1 134 ? -12.02200 -2.66317  -47.07701 1.000 52.62728 -1 189 ASP B OD2 1 
ATOM   2202 N N   . THR B 1 135 ? -10.03335 -5.30619  -51.61307 1.000 31.94714 ?  190 THR B N   1 
ATOM   2203 C CA  . THR B 1 135 ? -10.05350 -5.56787  -53.04742 1.000 35.11491 ?  190 THR B CA  1 
ATOM   2204 C C   . THR B 1 135 ? -10.13861 -7.06271  -53.33063 1.000 32.86260 ?  190 THR B C   1 
ATOM   2205 O O   . THR B 1 135 ? -10.85854 -7.48882  -54.23883 1.000 31.91588 ?  190 THR B O   1 
ATOM   2206 C CB  . THR B 1 135 ? -8.81233  -4.94661  -53.69807 1.000 36.82777 ?  190 THR B CB  1 
ATOM   2207 O OG1 . THR B 1 135 ? -8.96775  -3.51872  -53.74127 1.000 44.24430 ?  190 THR B OG1 1 
ATOM   2208 C CG2 . THR B 1 135 ? -8.60064  -5.48160  -55.11029 1.000 38.67136 ?  190 THR B CG2 1 
ATOM   2209 N N   . PHE B 1 136 ? -9.41227  -7.87684  -52.56061 1.000 31.76018 ?  191 PHE B N   1 
ATOM   2210 C CA  . PHE B 1 136 ? -9.52982  -9.32523  -52.69962 1.000 30.26699 ?  191 PHE B CA  1 
ATOM   2211 C C   . PHE B 1 136 ? -10.97903 -9.78186  -52.54238 1.000 29.20926 ?  191 PHE B C   1 
ATOM   2212 O O   . PHE B 1 136 ? -11.45480 -10.63455 -53.29983 1.000 29.12562 ?  191 PHE B O   1 
ATOM   2213 C CB  . PHE B 1 136 ? -8.63100  -10.02106 -51.67234 1.000 28.39306 ?  191 PHE B CB  1 
ATOM   2214 C CG  . PHE B 1 136 ? -8.71102  -11.52611 -51.72092 1.000 27.82796 ?  191 PHE B CG  1 
ATOM   2215 C CD1 . PHE B 1 136 ? -8.06066  -12.23830 -52.72130 1.000 25.74977 ?  191 PHE B CD1 1 
ATOM   2216 C CD2 . PHE B 1 136 ? -9.43946  -12.22606 -50.77804 1.000 27.48044 ?  191 PHE B CD2 1 
ATOM   2217 C CE1 . PHE B 1 136 ? -8.12920  -13.62495 -52.76770 1.000 26.13983 ?  191 PHE B CE1 1 
ATOM   2218 C CE2 . PHE B 1 136 ? -9.51221  -13.61987 -50.82300 1.000 22.99524 ?  191 PHE B CE2 1 
ATOM   2219 C CZ  . PHE B 1 136 ? -8.86345  -14.31350 -51.82182 1.000 22.24118 ?  191 PHE B CZ  1 
ATOM   2220 N N   . VAL B 1 137 ? -11.69068 -9.22994  -51.55341 1.000 25.44874 ?  192 VAL B N   1 
ATOM   2221 C CA  . VAL B 1 137 ? -13.08780 -9.58916  -51.33314 1.000 33.85762 ?  192 VAL B CA  1 
ATOM   2222 C C   . VAL B 1 137 ? -13.95903 -9.09864  -52.48297 1.000 31.61431 ?  192 VAL B C   1 
ATOM   2223 O O   . VAL B 1 137 ? -14.87492 -9.80175  -52.92259 1.000 30.01736 ?  192 VAL B O   1 
ATOM   2224 C CB  . VAL B 1 137 ? -13.57197 -9.02476  -49.98740 1.000 30.64009 ?  192 VAL B CB  1 
ATOM   2225 C CG1 . VAL B 1 137 ? -14.99108 -9.51380  -49.68979 1.000 31.12720 ?  192 VAL B CG1 1 
ATOM   2226 C CG2 . VAL B 1 137 ? -12.60928 -9.44306  -48.89759 1.000 30.49182 ?  192 VAL B CG2 1 
ATOM   2227 N N   . GLU B 1 138 ? -13.68122 -7.88948  -52.98810 1.000 33.63785 ?  193 GLU B N   1 
ATOM   2228 C CA  . GLU B 1 138 ? -14.46539 -7.33101  -54.09010 1.000 36.27503 ?  193 GLU B CA  1 
ATOM   2229 C C   . GLU B 1 138 ? -14.30227 -8.14921  -55.36600 1.000 36.31486 ?  193 GLU B C   1 
ATOM   2230 O O   . GLU B 1 138 ? -15.26533 -8.33483  -56.11782 1.000 37.70636 ?  193 GLU B O   1 
ATOM   2231 C CB  . GLU B 1 138 ? -14.04459 -5.88723  -54.35265 1.000 37.02698 ?  193 GLU B CB  1 
ATOM   2232 C CG  . GLU B 1 138 ? -14.45620 -4.90454  -53.27879 1.000 37.84797 ?  193 GLU B CG  1 
ATOM   2233 C CD  . GLU B 1 138 ? -13.81875 -3.53490  -53.48692 1.000 43.71661 ?  193 GLU B CD  1 
ATOM   2234 O OE1 . GLU B 1 138 ? -12.97653 -3.37203  -54.41491 1.000 39.60647 ?  193 GLU B OE1 1 
ATOM   2235 O OE2 . GLU B 1 138 ? -14.16821 -2.61580  -52.72061 1.000 47.47753 -1 193 GLU B OE2 1 
ATOM   2236 N N   . LEU B 1 139 ? -13.08460 -8.63137  -55.63982 1.000 33.11337 ?  194 LEU B N   1 
ATOM   2237 C CA  . LEU B 1 139 ? -12.84620 -9.38747  -56.86778 1.000 34.02177 ?  194 LEU B CA  1 
ATOM   2238 C C   . LEU B 1 139 ? -13.24234 -10.86059 -56.75281 1.000 35.71903 ?  194 LEU B C   1 
ATOM   2239 O O   . LEU B 1 139 ? -13.62416 -11.47247 -57.75978 1.000 37.68783 ?  194 LEU B O   1 
ATOM   2240 C CB  . LEU B 1 139 ? -11.37913 -9.29329  -57.26494 1.000 31.76270 ?  194 LEU B CB  1 
ATOM   2241 C CG  . LEU B 1 139 ? -10.91944 -8.21903  -58.25066 1.000 37.14893 ?  194 LEU B CG  1 
ATOM   2242 C CD1 . LEU B 1 139 ? -11.59355 -6.91063  -57.95566 1.000 40.36065 ?  194 LEU B CD1 1 
ATOM   2243 C CD2 . LEU B 1 139 ? -9.41589  -8.05831  -58.14784 1.000 39.67104 ?  194 LEU B CD2 1 
ATOM   2244 N N   . TYR B 1 140 ? -13.15830 -11.45774 -55.55405 1.000 33.61844 ?  195 TYR B N   1 
ATOM   2245 C CA  . TYR B 1 140 ? -13.26836 -12.90905 -55.44936 1.000 31.28480 ?  195 TYR B CA  1 
ATOM   2246 C C   . TYR B 1 140 ? -14.14947 -13.38791 -54.30205 1.000 37.55385 ?  195 TYR B C   1 
ATOM   2247 O O   . TYR B 1 140 ? -14.20807 -14.59790 -54.06013 1.000 37.62905 ?  195 TYR B O   1 
ATOM   2248 C CB  . TYR B 1 140 ? -11.87280 -13.54364 -55.29045 1.000 30.19534 ?  195 TYR B CB  1 
ATOM   2249 C CG  . TYR B 1 140 ? -10.82457 -12.99199 -56.23508 1.000 32.79048 ?  195 TYR B CG  1 
ATOM   2250 C CD1 . TYR B 1 140 ? -10.80545 -13.35561 -57.59039 1.000 34.69615 ?  195 TYR B CD1 1 
ATOM   2251 C CD2 . TYR B 1 140 ? -9.84997  -12.12094 -55.77993 1.000 34.20685 ?  195 TYR B CD2 1 
ATOM   2252 C CE1 . TYR B 1 140 ? -9.83893  -12.84099 -58.46622 1.000 34.31310 ?  195 TYR B CE1 1 
ATOM   2253 C CE2 . TYR B 1 140 ? -8.88387  -11.60676 -56.63929 1.000 32.96974 ?  195 TYR B CE2 1 
ATOM   2254 C CZ  . TYR B 1 140 ? -8.88126  -11.96759 -57.97800 1.000 33.30885 ?  195 TYR B CZ  1 
ATOM   2255 O OH  . TYR B 1 140 ? -7.91211  -11.44389 -58.80937 1.000 40.99468 ?  195 TYR B OH  1 
ATOM   2256 N N   . GLY B 1 141 ? -14.81593 -12.49832 -53.57333 1.000 36.94161 ?  196 GLY B N   1 
ATOM   2257 C CA  . GLY B 1 141 ? -15.70266 -12.92867 -52.50613 1.000 38.42779 ?  196 GLY B CA  1 
ATOM   2258 C C   . GLY B 1 141 ? -17.15108 -13.04704 -52.95776 1.000 45.58422 ?  196 GLY B C   1 
ATOM   2259 O O   . GLY B 1 141 ? -17.48995 -12.71074 -54.10094 1.000 50.86479 ?  196 GLY B O   1 
ATOM   2260 N N   . THR C 2 1   ? -9.48427  -19.27202 -60.15014 1.000 34.30330 ?  1   THR D N   1 
ATOM   2261 C CA  . THR C 2 1   ? -10.02204 -18.44431 -61.23461 1.000 32.74822 ?  1   THR D CA  1 
ATOM   2262 C C   . THR C 2 1   ? -9.15881  -18.65701 -62.47887 1.000 34.20594 ?  1   THR D C   1 
ATOM   2263 O O   . THR C 2 1   ? -7.98853  -19.01470 -62.36147 1.000 32.41118 ?  1   THR D O   1 
ATOM   2264 C CB  . THR C 2 1   ? -10.06165 -16.91320 -60.86402 1.000 37.60558 ?  1   THR D CB  1 
ATOM   2265 O OG1 . THR C 2 1   ? -8.73506  -16.37132 -60.83918 1.000 29.39327 ?  1   THR D OG1 1 
ATOM   2266 C CG2 . THR C 2 1   ? -10.71944 -16.67802 -59.51240 1.000 36.89845 ?  1   THR D CG2 1 
ATOM   2267 N N   . PRO C 2 2   ? -9.72776  -18.44771 -63.67061 1.000 33.25987 ?  2   PRO D N   1 
ATOM   2268 C CA  . PRO C 2 2   ? -8.92500  -18.66063 -64.88763 1.000 33.86756 ?  2   PRO D CA  1 
ATOM   2269 C C   . PRO C 2 2   ? -7.65858  -17.82036 -64.92626 1.000 33.98461 ?  2   PRO D C   1 
ATOM   2270 O O   . PRO C 2 2   ? -6.63288  -18.28918 -65.43252 1.000 31.45976 ?  2   PRO D O   1 
ATOM   2271 C CB  . PRO C 2 2   ? -9.89921  -18.29040 -66.01884 1.000 32.72269 ?  2   PRO D CB  1 
ATOM   2272 C CG  . PRO C 2 2   ? -11.26306 -18.42278 -65.41366 1.000 34.54562 ?  2   PRO D CG  1 
ATOM   2273 C CD  . PRO C 2 2   ? -11.11232 -18.03700 -63.98193 1.000 30.08986 ?  2   PRO D CD  1 
ATOM   2274 N N   . GLU C 2 3   ? -7.69660  -16.59142 -64.38879 1.000 34.04705 ?  3   GLU D N   1 
ATOM   2275 C CA  . GLU C 2 3   ? -6.50866  -15.74330 -64.40726 1.000 34.56656 ?  3   GLU D CA  1 
ATOM   2276 C C   . GLU C 2 3   ? -5.46172  -16.21262 -63.39283 1.000 35.12448 ?  3   GLU D C   1 
ATOM   2277 O O   . GLU C 2 3   ? -4.25931  -16.13222 -63.66598 1.000 37.07189 ?  3   GLU D O   1 
ATOM   2278 C CB  . GLU C 2 3   ? -6.89260  -14.27909 -64.17143 1.000 32.95950 ?  3   GLU D CB  1 
ATOM   2279 C CG  . GLU C 2 3   ? -7.43751  -13.97441 -62.78315 1.000 32.47201 ?  3   GLU D CG  1 
ATOM   2280 C CD  . GLU C 2 3   ? -8.94266  -14.02549 -62.73739 1.000 36.94783 ?  3   GLU D CD  1 
ATOM   2281 O OE1 . GLU C 2 3   ? -9.53772  -14.76619 -63.55680 1.000 38.07457 ?  3   GLU D OE1 1 
ATOM   2282 O OE2 . GLU C 2 3   ? -9.53628  -13.30521 -61.90311 1.000 42.62918 -1 3   GLU D OE2 1 
ATOM   2283 N N   . TRP C 2 4   ? -5.88242  -16.72828 -62.22966 1.000 31.04443 ?  4   TRP D N   1 
ATOM   2284 C CA  . TRP C 2 4   ? -4.90629  -17.34641 -61.33020 1.000 30.18793 ?  4   TRP D CA  1 
ATOM   2285 C C   . TRP C 2 4   ? -4.31248  -18.60077 -61.95288 1.000 32.41367 ?  4   TRP D C   1 
ATOM   2286 O O   . TRP C 2 4   ? -3.09410  -18.79953 -61.92357 1.000 29.95254 ?  4   TRP D O   1 
ATOM   2287 C CB  . TRP C 2 4   ? -5.53954  -17.69053 -59.98555 1.000 28.63009 ?  4   TRP D CB  1 
ATOM   2288 C CG  . TRP C 2 4   ? -6.04054  -16.50770 -59.21991 1.000 28.56850 ?  4   TRP D CG  1 
ATOM   2289 C CD1 . TRP C 2 4   ? -5.87996  -15.18833 -59.53463 1.000 31.73677 ?  4   TRP D CD1 1 
ATOM   2290 C CD2 . TRP C 2 4   ? -6.79367  -16.54538 -58.00936 1.000 23.59700 ?  4   TRP D CD2 1 
ATOM   2291 N NE1 . TRP C 2 4   ? -6.49438  -14.39954 -58.58048 1.000 28.98284 ?  4   TRP D NE1 1 
ATOM   2292 C CE2 . TRP C 2 4   ? -7.06115  -15.21536 -57.63640 1.000 29.94635 ?  4   TRP D CE2 1 
ATOM   2293 C CE3 . TRP C 2 4   ? -7.26495  -17.58157 -57.19489 1.000 30.56325 ?  4   TRP D CE3 1 
ATOM   2294 C CZ2 . TRP C 2 4   ? -7.78390  -14.89447 -56.48254 1.000 29.19959 ?  4   TRP D CZ2 1 
ATOM   2295 C CZ3 . TRP C 2 4   ? -7.98547  -17.26454 -56.06077 1.000 27.67035 ?  4   TRP D CZ3 1 
ATOM   2296 C CH2 . TRP C 2 4   ? -8.23952  -15.93128 -55.71096 1.000 28.12757 ?  4   TRP D CH2 1 
ATOM   2297 N N   . ALA C 2 5   ? -5.16984  -19.46306 -62.51788 1.000 32.09306 ?  5   ALA D N   1 
ATOM   2298 C CA  . ALA C 2 5   ? -4.70060  -20.70428 -63.12939 1.000 33.47251 ?  5   ALA D CA  1 
ATOM   2299 C C   . ALA C 2 5   ? -3.70462  -20.43411 -64.25166 1.000 36.54483 ?  5   ALA D C   1 
ATOM   2300 O O   . ALA C 2 5   ? -2.72615  -21.17705 -64.41543 1.000 36.40975 ?  5   ALA D O   1 
ATOM   2301 C CB  . ALA C 2 5   ? -5.89390  -21.51172 -63.64397 1.000 35.50865 ?  5   ALA D CB  1 
ATOM   2302 N N   . SER C 2 6   ? -3.91315  -19.35405 -65.01528 1.000 36.88859 ?  6   SER D N   1 
ATOM   2303 C CA  . SER C 2 6   ? -3.04337  -19.07469 -66.15423 1.000 34.54967 ?  6   SER D CA  1 
ATOM   2304 C C   . SER C 2 6   ? -1.61816  -18.71916 -65.74591 1.000 35.96788 ?  6   SER D C   1 
ATOM   2305 O O   . SER C 2 6   ? -0.74070  -18.66437 -66.61525 1.000 37.22652 ?  6   SER D O   1 
ATOM   2306 C CB  . SER C 2 6   ? -3.62933  -17.94863 -67.00181 1.000 35.64938 ?  6   SER D CB  1 
ATOM   2307 O OG  . SER C 2 6   ? -3.41937  -16.69575 -66.38198 1.000 40.84184 ?  6   SER D OG  1 
ATOM   2308 N N   . THR C 2 7   ? -1.35604  -18.49140 -64.45912 1.000 36.55722 ?  7   THR D N   1 
ATOM   2309 C CA  . THR C 2 7   ? -0.00742  -18.20142 -63.99123 1.000 34.55990 ?  7   THR D CA  1 
ATOM   2310 C C   . THR C 2 7   ? 0.67870   -19.41858 -63.37942 1.000 36.66501 ?  7   THR D C   1 
ATOM   2311 O O   . THR C 2 7   ? 1.81876   -19.30793 -62.91890 1.000 34.98221 ?  7   THR D O   1 
ATOM   2312 C CB  . THR C 2 7   ? -0.03336  -17.03158 -62.99343 1.000 36.24802 ?  7   THR D CB  1 
ATOM   2313 O OG1 . THR C 2 7   ? -0.54443  -17.48122 -61.73450 1.000 33.25698 ?  7   THR D OG1 1 
ATOM   2314 C CG2 . THR C 2 7   ? -0.92206  -15.89459 -63.52177 1.000 30.96580 ?  7   THR D CG2 1 
ATOM   2315 N N   . LEU C 2 8   ? 0.02821   -20.57877 -63.37844 1.000 38.32476 ?  8   LEU D N   1 
ATOM   2316 C CA  . LEU C 2 8   ? 0.72746   -21.81124 -63.03832 1.000 39.75454 ?  8   LEU D CA  1 
ATOM   2317 C C   . LEU C 2 8   ? 1.73354   -22.18130 -64.12890 1.000 42.56547 ?  8   LEU D C   1 
ATOM   2318 O O   . LEU C 2 8   ? 1.57007   -21.83613 -65.30384 1.000 41.62101 ?  8   LEU D O   1 
ATOM   2319 C CB  . LEU C 2 8   ? -0.27132  -22.95664 -62.85676 1.000 40.46115 ?  8   LEU D CB  1 
ATOM   2320 C CG  . LEU C 2 8   ? -1.11997  -22.95836 -61.58859 1.000 36.17364 ?  8   LEU D CG  1 
ATOM   2321 C CD1 . LEU C 2 8   ? -2.36045  -23.78135 -61.80898 1.000 34.37762 ?  8   LEU D CD1 1 
ATOM   2322 C CD2 . LEU C 2 8   ? -0.32681  -23.49455 -60.43678 1.000 32.08434 ?  8   LEU D CD2 1 
ATOM   2323 N N   . ARG C 2 9   ? 2.77903   -22.90377 -63.73411 1.000 46.23167 ?  9   ARG D N   1 
ATOM   2324 C CA  . ARG C 2 9   ? 3.65916   -23.51028 -64.72202 1.000 47.60415 ?  9   ARG D CA  1 
ATOM   2325 C C   . ARG C 2 9   ? 2.90882   -24.61467 -65.46814 1.000 51.82022 ?  9   ARG D C   1 
ATOM   2326 O O   . ARG C 2 9   ? 2.05821   -25.29865 -64.88669 1.000 49.94387 ?  9   ARG D O   1 
ATOM   2327 C CB  . ARG C 2 9   ? 4.91409   -24.08592 -64.05922 1.000 48.62033 ?  9   ARG D CB  1 
ATOM   2328 C CG  . ARG C 2 9   ? 5.92583   -23.02819 -63.61753 1.000 51.60052 ?  9   ARG D CG  1 
ATOM   2329 C CD  . ARG C 2 9   ? 7.24558   -23.66121 -63.15093 1.000 58.05416 ?  9   ARG D CD  1 
ATOM   2330 N NE  . ARG C 2 9   ? 7.12107   -24.25064 -61.82011 1.000 59.30568 ?  9   ARG D NE  1 
ATOM   2331 C CZ  . ARG C 2 9   ? 7.64668   -25.41805 -61.45846 1.000 59.74120 ?  9   ARG D CZ  1 
ATOM   2332 N NH1 . ARG C 2 9   ? 8.34763   -26.13351 -62.33115 1.000 61.60918 ?  9   ARG D NH1 1 
ATOM   2333 N NH2 . ARG C 2 9   ? 7.46845   -25.87148 -60.22111 1.000 58.17652 ?  9   ARG D NH2 1 
ATOM   2334 N N   . PRO C 2 10  ? 3.20173   -24.80756 -66.76125 1.000 55.69575 ?  10  PRO D N   1 
ATOM   2335 C CA  . PRO C 2 10  ? 2.48465   -25.84913 -67.52562 1.000 56.75239 ?  10  PRO D CA  1 
ATOM   2336 C C   . PRO C 2 10  ? 2.53503   -27.23671 -66.89400 1.000 55.93787 ?  10  PRO D C   1 
ATOM   2337 O O   . PRO C 2 10  ? 1.56161   -27.98832 -67.02142 1.000 52.76375 ?  10  PRO D O   1 
ATOM   2338 C CB  . PRO C 2 10  ? 3.17629   -25.82039 -68.90032 1.000 54.48911 ?  10  PRO D CB  1 
ATOM   2339 C CG  . PRO C 2 10  ? 4.38359   -24.93149 -68.74173 1.000 55.21831 ?  10  PRO D CG  1 
ATOM   2340 C CD  . PRO C 2 10  ? 4.08084   -24.00013 -67.62103 1.000 50.57187 ?  10  PRO D CD  1 
ATOM   2341 N N   . GLU C 2 11  ? 3.61950   -27.59339 -66.20295 1.000 56.90993 ?  11  GLU D N   1 
ATOM   2342 C CA  . GLU C 2 11  ? 3.71501   -28.88954 -65.51804 1.000 51.46430 ?  11  GLU D CA  1 
ATOM   2343 C C   . GLU C 2 11  ? 2.75416   -28.99008 -64.33342 1.000 57.76296 ?  11  GLU D C   1 
ATOM   2344 O O   . GLU C 2 11  ? 2.34906   -30.09054 -63.94347 1.000 58.26026 ?  11  GLU D O   1 
ATOM   2345 C CB  . GLU C 2 11  ? 5.14704   -29.14022 -65.03130 1.000 54.13836 ?  11  GLU D CB  1 
ATOM   2346 C CG  . GLU C 2 11  ? 5.77280   -27.94861 -64.31058 1.000 57.63693 ?  11  GLU D CG  1 
ATOM   2347 C CD  . GLU C 2 11  ? 6.64452   -27.09805 -65.22210 1.000 60.04920 ?  11  GLU D CD  1 
ATOM   2348 O OE1 . GLU C 2 11  ? 7.74134   -26.68179 -64.77907 1.000 60.95897 ?  11  GLU D OE1 1 
ATOM   2349 O OE2 . GLU C 2 11  ? 6.23657   -26.85936 -66.38373 1.000 57.00623 -1 11  GLU D OE2 1 
HETATM 2350 N N   . CCS C 2 12  ? 2.39960   -27.84338 -63.75326 1.000 56.73771 ?  12  CCS D N   1 
HETATM 2351 C CA  . CCS C 2 12  ? 1.47766   -27.81672 -62.58314 1.000 54.91417 ?  12  CCS D CA  1 
HETATM 2352 C CB  . CCS C 2 12  ? 1.88705   -26.72663 -61.61473 1.000 47.77262 ?  12  CCS D CB  1 
HETATM 2353 S SG  . CCS C 2 12  ? 3.62167   -26.75953 -61.11845 1.000 51.56433 ?  12  CCS D SG  1 
HETATM 2354 C CD  . CCS C 2 12  ? 3.61249   -25.64735 -59.68284 1.000 46.84106 ?  12  CCS D CD  1 
HETATM 2355 C CE  . CCS C 2 12  ? 3.93301   -24.21885 -60.06708 1.000 43.94822 ?  12  CCS D CE  1 
HETATM 2356 O OZ1 . CCS C 2 12  ? 3.29199   -23.63467 -60.93948 1.000 43.48956 ?  12  CCS D OZ1 1 
HETATM 2357 C C   . CCS C 2 12  ? 0.03886   -27.58162 -63.05371 1.000 53.14726 ?  12  CCS D C   1 
HETATM 2358 O O   . CCS C 2 12  ? -0.11337  -27.10555 -64.19956 1.000 53.00679 ?  12  CCS D O   1 
HETATM 2359 N NAA . EDN C 2 13  ? 4.91766   -23.64762 -59.38460 1.000 38.92276 ?  13  EDN D NAA 1 
HETATM 2360 C CAB . EDN C 2 13  ? 5.21956   -22.22782 -59.47645 1.000 39.53104 ?  13  EDN D CAB 1 
HETATM 2361 C CAC . EDN C 2 13  ? 4.75739   -21.49656 -58.23734 1.000 35.54851 ?  13  EDN D CAC 1 
HETATM 2362 N NAD . EDN C 2 13  ? 3.30772   -21.42203 -58.16369 1.000 27.92896 ?  13  EDN D NAD 1 
HETATM 2363 C C1  . Z7Z C 2 14  ? 2.60924   -20.47943 -58.79879 1.000 33.19881 ?  14  Z7Z D C1  1 
HETATM 2364 O O2  . Z7Z C 2 14  ? 3.13220   -19.65532 -59.54842 1.000 32.51682 ?  14  Z7Z D O2  1 
HETATM 2365 C C2  . Z7Z C 2 14  ? 1.12051   -20.53252 -58.62486 1.000 30.67725 ?  14  Z7Z D C2  1 
HETATM 2366 C C3  . Z7Z C 2 14  ? 0.26662   -19.98354 -59.56995 1.000 31.72608 ?  14  Z7Z D C3  1 
HETATM 2367 C C4  . Z7Z C 2 14  ? -1.10081  -20.08664 -59.41139 1.000 27.48415 ?  14  Z7Z D C4  1 
HETATM 2368 C C5  . Z7Z C 2 14  ? 0.58215   -21.16475 -57.51215 1.000 28.36604 ?  14  Z7Z D C5  1 
HETATM 2369 C C6  . Z7Z C 2 14  ? -0.78609  -21.24427 -57.35201 1.000 29.60285 ?  14  Z7Z D C6  1 
HETATM 2370 C C7  . Z7Z C 2 14  ? -1.65409  -20.68218 -58.28383 1.000 29.48925 ?  14  Z7Z D C7  1 
HETATM 2371 C C8  . Z7Z C 2 14  ? -3.12671  -20.80074 -58.13664 1.000 26.97902 ?  14  Z7Z D C8  1 
HETATM 2372 C C9  . Z7Z C 2 14  ? -3.91002  -21.16224 -59.22781 1.000 33.46774 ?  14  Z7Z D C9  1 
HETATM 2373 C C10 . Z7Z C 2 14  ? -3.77889  -20.52080 -56.93783 1.000 28.43460 ?  14  Z7Z D C10 1 
HETATM 2374 C C11 . Z7Z C 2 14  ? -5.28298  -21.27917 -59.12757 1.000 29.72632 ?  14  Z7Z D C11 1 
HETATM 2375 C C12 . Z7Z C 2 14  ? -5.15356  -20.62527 -56.83150 1.000 27.09922 ?  14  Z7Z D C12 1 
HETATM 2376 C C13 . Z7Z C 2 14  ? -5.92467  -21.02892 -57.92230 1.000 30.05120 ?  14  Z7Z D C13 1 
HETATM 2377 N N   . PRS C 2 15  ? -8.17764  -21.12675 -58.82872 1.000 30.14308 ?  15  PRS D N   1 
HETATM 2378 C CD  . PRS C 2 15  ? -7.38988  -21.12383 -57.82744 1.000 31.61028 ?  15  PRS D CD  1 
HETATM 2379 C CA  . PRS C 2 15  ? -9.58561  -20.98046 -58.41513 1.000 34.39131 ?  15  PRS D CA  1 
HETATM 2380 C CB  . PRS C 2 15  ? -9.60496  -20.44012 -56.98250 1.000 31.80846 ?  15  PRS D CB  1 
HETATM 2381 S SG  . PRS C 2 15  ? -8.13890  -21.18700 -56.23959 1.000 33.00781 ?  15  PRS D SG  1 
HETATM 2382 C C   . PRS C 2 15  ? -10.26877 -19.98707 -59.33049 1.000 34.03921 ?  15  PRS D C   1 
HETATM 2383 O O   . PRS C 2 15  ? -11.44699 -19.84829 -59.24201 1.000 36.44608 ?  15  PRS D O   1 
ATOM   2384 N N   . THR D 2 1   ? -18.65969 -11.32447 -10.13560 1.000 26.67862 ?  1   THR C N   1 
ATOM   2385 C CA  . THR D 2 1   ? -18.17576 -12.16577 -9.04451  1.000 27.43114 ?  1   THR C CA  1 
ATOM   2386 C C   . THR D 2 1   ? -18.46492 -11.39103 -7.76271  1.000 28.94000 ?  1   THR C C   1 
ATOM   2387 O O   . THR D 2 1   ? -18.57251 -10.16258 -7.80950  1.000 30.03253 ?  1   THR C O   1 
ATOM   2388 C CB  . THR D 2 1   ? -16.64089 -12.46621 -9.12064  1.000 27.99037 ?  1   THR C CB  1 
ATOM   2389 O OG1 . THR D 2 1   ? -15.91018 -11.25652 -8.87481  1.000 28.77308 ?  1   THR C OG1 1 
ATOM   2390 C CG2 . THR D 2 1   ? -16.21928 -13.05517 -10.47674 1.000 27.74763 ?  1   THR C CG2 1 
ATOM   2391 N N   . PRO D 2 2   ? -18.58253 -12.09989 -6.62985  1.000 29.34648 ?  2   PRO C N   1 
ATOM   2392 C CA  . PRO D 2 2   ? -18.73004 -11.39483 -5.33687  1.000 29.07751 ?  2   PRO C CA  1 
ATOM   2393 C C   . PRO D 2 2   ? -17.61563 -10.40150 -5.04596  1.000 30.16964 ?  2   PRO C C   1 
ATOM   2394 O O   . PRO D 2 2   ? -17.87344 -9.31840  -4.50665  1.000 29.75068 ?  2   PRO C O   1 
ATOM   2395 C CB  . PRO D 2 2   ? -18.74129 -12.54707 -4.31981  1.000 31.88400 ?  2   PRO C CB  1 
ATOM   2396 C CG  . PRO D 2 2   ? -19.27445 -13.73667 -5.10340  1.000 30.60102 ?  2   PRO C CG  1 
ATOM   2397 C CD  . PRO D 2 2   ? -18.69685 -13.56877 -6.48942  1.000 29.58596 ?  2   PRO C CD  1 
ATOM   2398 N N   . GLU D 2 3   ? -16.36435 -10.73580 -5.37142  1.000 28.30434 ?  3   GLU C N   1 
ATOM   2399 C CA  . GLU D 2 3   ? -15.28941 -9.79177  -5.08351  1.000 31.52158 ?  3   GLU C CA  1 
ATOM   2400 C C   . GLU D 2 3   ? -15.40804 -8.52157  -5.93460  1.000 29.90303 ?  3   GLU C C   1 
ATOM   2401 O O   . GLU D 2 3   ? -15.11330 -7.43118  -5.43829  1.000 33.25233 ?  3   GLU C O   1 
ATOM   2402 C CB  . GLU D 2 3   ? -13.92837 -10.49343 -5.24909  1.000 29.61898 ?  3   GLU C CB  1 
ATOM   2403 C CG  . GLU D 2 3   ? -13.59877 -10.85785 -6.67766  1.000 33.13423 ?  3   GLU C CG  1 
ATOM   2404 C CD  . GLU D 2 3   ? -13.87608 -12.31838 -7.03906  1.000 31.32287 ?  3   GLU C CD  1 
ATOM   2405 O OE1 . GLU D 2 3   ? -14.81896 -12.95102 -6.46390  1.000 30.68675 ?  3   GLU C OE1 1 
ATOM   2406 O OE2 . GLU D 2 3   ? -13.20258 -12.80619 -7.97353  1.000 33.28110 -1 3   GLU C OE2 1 
ATOM   2407 N N   . TRP D 2 4   ? -15.88007 -8.61667  -7.19117  1.000 28.39809 ?  4   TRP C N   1 
ATOM   2408 C CA  . TRP D 2 4   ? -16.06717 -7.38811  -7.97516  1.000 27.53914 ?  4   TRP C CA  1 
ATOM   2409 C C   . TRP D 2 4   ? -17.32076 -6.63298  -7.53542  1.000 28.54567 ?  4   TRP C C   1 
ATOM   2410 O O   . TRP D 2 4   ? -17.31736 -5.39697  -7.46091  1.000 25.46426 ?  4   TRP C O   1 
ATOM   2411 C CB  . TRP D 2 4   ? -16.12993 -7.70118  -9.47520  1.000 22.54267 ?  4   TRP C CB  1 
ATOM   2412 C CG  . TRP D 2 4   ? -14.94807 -8.47746  -10.00904 1.000 27.96648 ?  4   TRP C CG  1 
ATOM   2413 C CD1 . TRP D 2 4   ? -13.69240 -8.54845  -9.46687  1.000 22.21392 ?  4   TRP C CD1 1 
ATOM   2414 C CD2 . TRP D 2 4   ? -14.92699 -9.30675  -11.17617 1.000 23.44721 ?  4   TRP C CD2 1 
ATOM   2415 N NE1 . TRP D 2 4   ? -12.89466 -9.37545  -10.22593 1.000 25.76093 ?  4   TRP C NE1 1 
ATOM   2416 C CE2 . TRP D 2 4   ? -13.63162 -9.84659  -11.28446 1.000 27.60934 ?  4   TRP C CE2 1 
ATOM   2417 C CE3 . TRP D 2 4   ? -15.87966 -9.63661  -12.14791 1.000 26.21600 ?  4   TRP C CE3 1 
ATOM   2418 C CZ2 . TRP D 2 4   ? -13.26479 -10.70002 -12.32965 1.000 25.34791 ?  4   TRP C CZ2 1 
ATOM   2419 C CZ3 . TRP D 2 4   ? -15.51387 -10.48616 -13.17656 1.000 25.03911 ?  4   TRP C CZ3 1 
ATOM   2420 C CH2 . TRP D 2 4   ? -14.22199 -11.00349 -13.25987 1.000 21.95112 ?  4   TRP C CH2 1 
ATOM   2421 N N   . ALA D 2 5   ? -18.39766 -7.36445  -7.22966  1.000 27.49460 ?  5   ALA C N   1 
ATOM   2422 C CA  . ALA D 2 5   ? -19.64060 -6.73254  -6.79836  1.000 26.49663 ?  5   ALA C CA  1 
ATOM   2423 C C   . ALA D 2 5   ? -19.45777 -5.90449  -5.53397  1.000 31.21977 ?  5   ALA C C   1 
ATOM   2424 O O   . ALA D 2 5   ? -20.18273 -4.92902  -5.32737  1.000 25.70381 ?  5   ALA C O   1 
ATOM   2425 C CB  . ALA D 2 5   ? -20.71739 -7.79291  -6.57122  1.000 30.70481 ?  5   ALA C CB  1 
ATOM   2426 N N   . SER D 2 6   ? -18.49105 -6.25609  -4.68229  1.000 28.82022 ?  6   SER C N   1 
ATOM   2427 C CA  . SER D 2 6   ? -18.32505 -5.50685  -3.44221  1.000 29.69677 ?  6   SER C CA  1 
ATOM   2428 C C   . SER D 2 6   ? -17.61571 -4.16620  -3.63611  1.000 29.55887 ?  6   SER C C   1 
ATOM   2429 O O   . SER D 2 6   ? -17.51904 -3.39159  -2.67837  1.000 27.89656 ?  6   SER C O   1 
ATOM   2430 C CB  . SER D 2 6   ? -17.56910 -6.35431  -2.42068  1.000 35.55604 ?  6   SER C CB  1 
ATOM   2431 O OG  . SER D 2 6   ? -16.21797 -6.47473  -2.80364  1.000 35.42780 ?  6   SER C OG  1 
ATOM   2432 N N   . THR D 2 7   ? -17.12941 -3.85929  -4.84034  1.000 30.14459 ?  7   THR C N   1 
ATOM   2433 C CA  . THR D 2 7   ? -16.57987 -2.53669  -5.12182  1.000 30.74780 ?  7   THR C CA  1 
ATOM   2434 C C   . THR D 2 7   ? -17.62432 -1.55437  -5.66301  1.000 29.72974 ?  7   THR C C   1 
ATOM   2435 O O   . THR D 2 7   ? -17.29523 -0.38359  -5.89958  1.000 32.83123 ?  7   THR C O   1 
ATOM   2436 C CB  . THR D 2 7   ? -15.40044 -2.63885  -6.10272  1.000 28.43421 ?  7   THR C CB  1 
ATOM   2437 O OG1 . THR D 2 7   ? -15.86908 -2.97400  -7.41412  1.000 27.50743 ?  7   THR C OG1 1 
ATOM   2438 C CG2 . THR D 2 7   ? -14.40603 -3.71817  -5.64454  1.000 26.75849 ?  7   THR C CG2 1 
ATOM   2439 N N   . LEU D 2 8   ? -18.86665 -1.98202  -5.86894  1.000 29.62605 ?  8   LEU C N   1 
ATOM   2440 C CA  . LEU D 2 8   ? -19.90990 -1.02184  -6.20277  1.000 33.44410 ?  8   LEU C CA  1 
ATOM   2441 C C   . LEU D 2 8   ? -20.11523 -0.05625  -5.04378  1.000 37.28623 ?  8   LEU C C   1 
ATOM   2442 O O   . LEU D 2 8   ? -19.87464 -0.39454  -3.88248  1.000 37.34279 ?  8   LEU C O   1 
ATOM   2443 C CB  . LEU D 2 8   ? -21.23391 -1.72014  -6.50809  1.000 34.45473 ?  8   LEU C CB  1 
ATOM   2444 C CG  . LEU D 2 8   ? -21.27650 -2.59771  -7.74970  1.000 32.02171 ?  8   LEU C CG  1 
ATOM   2445 C CD1 . LEU D 2 8   ? -22.40684 -3.58929  -7.60477  1.000 34.07845 ?  8   LEU C CD1 1 
ATOM   2446 C CD2 . LEU D 2 8   ? -21.42677 -1.73824  -9.00623  1.000 28.18043 ?  8   LEU C CD2 1 
ATOM   2447 N N   . ARG D 2 9   ? -20.55092 1.16115   -5.36897  1.000 39.41609 ?  9   ARG C N   1 
ATOM   2448 C CA  . ARG D 2 9   ? -21.03679 2.06868   -4.34133  1.000 44.02868 ?  9   ARG C CA  1 
ATOM   2449 C C   . ARG D 2 9   ? -22.33073 1.51285   -3.74290  1.000 45.49580 ?  9   ARG C C   1 
ATOM   2450 O O   . ARG D 2 9   ? -23.10351 0.84440   -4.43609  1.000 42.45177 ?  9   ARG C O   1 
ATOM   2451 C CB  . ARG D 2 9   ? -21.29124 3.45789   -4.92222  1.000 44.14069 ?  9   ARG C CB  1 
ATOM   2452 C CG  . ARG D 2 9   ? -20.05638 4.18508   -5.39045  1.000 50.89098 ?  9   ARG C CG  1 
ATOM   2453 C CD  . ARG D 2 9   ? -19.27359 4.75756   -4.21304  1.000 59.66944 ?  9   ARG C CD  1 
ATOM   2454 N NE  . ARG D 2 9   ? -19.02564 3.75362   -3.17613  1.000 63.13216 ?  9   ARG C NE  1 
ATOM   2455 C CZ  . ARG D 2 9   ? -18.51239 4.02410   -1.97756  1.000 66.12223 ?  9   ARG C CZ  1 
ATOM   2456 N NH1 . ARG D 2 9   ? -18.31505 3.04522   -1.09665  1.000 63.00279 ?  9   ARG C NH1 1 
ATOM   2457 N NH2 . ARG D 2 9   ? -18.18125 5.27305   -1.66405  1.000 64.34351 ?  9   ARG C NH2 1 
ATOM   2458 N N   . PRO D 2 10  ? -22.59239 1.77357   -2.45788  1.000 50.38483 ?  10  PRO C N   1 
ATOM   2459 C CA  . PRO D 2 10  ? -23.82084 1.23299   -1.83729  1.000 50.40809 ?  10  PRO C CA  1 
ATOM   2460 C C   . PRO D 2 10  ? -25.09319 1.62933   -2.56400  1.000 49.40131 ?  10  PRO C C   1 
ATOM   2461 O O   . PRO D 2 10  ? -26.03816 0.83270   -2.62094  1.000 48.44895 ?  10  PRO C O   1 
ATOM   2462 C CB  . PRO D 2 10  ? -23.78163 1.80887   -0.41268  1.000 50.46640 ?  10  PRO C CB  1 
ATOM   2463 C CG  . PRO D 2 10  ? -22.78475 2.94772   -0.46502  1.000 48.92012 ?  10  PRO C CG  1 
ATOM   2464 C CD  . PRO D 2 10  ? -21.78417 2.55618   -1.50538  1.000 51.12584 ?  10  PRO C CD  1 
ATOM   2465 N N   . GLU D 2 11  ? -25.13401 2.82710   -3.14123  1.000 50.50514 ?  11  GLU C N   1 
ATOM   2466 C CA  . GLU D 2 11  ? -26.28087 3.29973   -3.90928  1.000 50.07649 ?  11  GLU C CA  1 
ATOM   2467 C C   . GLU D 2 11  ? -26.55068 2.43197   -5.14299  1.000 53.07851 ?  11  GLU C C   1 
ATOM   2468 O O   . GLU D 2 11  ? -27.66849 2.41709   -5.67545  1.000 45.43656 ?  11  GLU C O   1 
ATOM   2469 C CB  . GLU D 2 11  ? -26.05289 4.75556   -4.33118  1.000 53.50915 ?  11  GLU C CB  1 
ATOM   2470 C CG  . GLU D 2 11  ? -24.69555 5.00340   -4.98647  1.000 53.47904 ?  11  GLU C CG  1 
ATOM   2471 C CD  . GLU D 2 11  ? -23.73355 5.81856   -4.11854  1.000 61.53871 ?  11  GLU C CD  1 
ATOM   2472 O OE1 . GLU D 2 11  ? -23.32791 6.92211   -4.55259  1.000 66.28721 -1 11  GLU C OE1 1 
ATOM   2473 O OE2 . GLU D 2 11  ? -23.36592 5.35433   -3.01172  1.000 61.43303 ?  11  GLU C OE2 1 
HETATM 2474 N N   . CCS D 2 12  ? -25.52092 1.70970   -5.58850  1.000 48.78602 ?  12  CCS C N   1 
HETATM 2475 C CA  . CCS D 2 12  ? -25.60159 0.85485   -6.80646  1.000 43.63978 ?  12  CCS C CA  1 
HETATM 2476 C CB  . CCS D 2 12  ? -24.41020 1.13550   -7.71274  1.000 39.67954 ?  12  CCS C CB  1 
HETATM 2477 S SG  . CCS D 2 12  ? -24.25503 2.85117   -8.26040  1.000 43.75346 ?  12  CCS C SG  1 
HETATM 2478 C CD  . CCS D 2 12  ? -22.94788 2.72710   -9.51859  1.000 32.95601 ?  12  CCS C CD  1 
HETATM 2479 C CE  . CCS D 2 12  ? -21.55018 2.81903   -8.93154  1.000 36.59241 ?  12  CCS C CE  1 
HETATM 2480 O OZ1 . CCS D 2 12  ? -21.12736 1.95588   -8.15985  1.000 35.05028 ?  12  CCS C OZ1 1 
HETATM 2481 C C   . CCS D 2 12  ? -25.64625 -0.62730  -6.41321  1.000 45.04188 ?  12  CCS C C   1 
HETATM 2482 O O   . CCS D 2 12  ? -25.73544 -1.45801  -7.33544  1.000 42.02496 -1 12  CCS C O   1 
HETATM 2483 N NAA . EDN D 2 13  ? -20.81232 3.83610   -9.37389  1.000 35.75340 ?  13  EDN C NAA 1 
HETATM 2484 C CAB . EDN D 2 13  ? -19.37098 3.93940   -9.19498  1.000 34.09730 ?  13  EDN C CAB 1 
HETATM 2485 C CAC . EDN D 2 13  ? -18.63676 3.50866   -10.45042 1.000 33.30969 ?  13  EDN C CAC 1 
HETATM 2486 N NAD . EDN D 2 13  ? -18.80556 2.08621   -10.70453 1.000 27.93306 ?  13  EDN C NAD 1 
HETATM 2487 C C1  . Z7Z D 2 14  ? -18.05955 1.16078   -10.09786 1.000 27.61978 ?  14  Z7Z C C1  1 
HETATM 2488 O O2  . Z7Z D 2 14  ? -17.20559 1.44672   -9.25925  1.000 27.82740 ?  14  Z7Z C O2  1 
HETATM 2489 C C2  . Z7Z D 2 14  ? -18.31509 -0.27533  -10.46237 1.000 26.68100 ?  14  Z7Z C C2  1 
HETATM 2490 C C3  . Z7Z D 2 14  ? -18.95050 -0.63356  -11.64503 1.000 24.77197 ?  14  Z7Z C C3  1 
HETATM 2491 C C4  . Z7Z D 2 14  ? -19.15458 -1.96680  -11.94367 1.000 21.54746 ?  14  Z7Z C C4  1 
HETATM 2492 C C5  . Z7Z D 2 14  ? -17.90912 -1.27216  -9.58578  1.000 24.61015 ?  14  Z7Z C C5  1 
HETATM 2493 C C6  . Z7Z D 2 14  ? -18.12040 -2.60238  -9.88484  1.000 25.72576 ?  14  Z7Z C C6  1 
HETATM 2494 C C7  . Z7Z D 2 14  ? -18.74508 -2.97804  -11.07172 1.000 22.98998 ?  14  Z7Z C C7  1 
HETATM 2495 C C8  . Z7Z D 2 14  ? -18.98700 -4.40436  -11.38658 1.000 22.60831 ?  14  Z7Z C C8  1 
HETATM 2496 C C9  . Z7Z D 2 14  ? -19.33073 -5.30907  -10.38124 1.000 25.19627 ?  14  Z7Z C C9  1 
HETATM 2497 C C10 . Z7Z D 2 14  ? -18.87161 -4.89670  -12.68655 1.000 21.76453 ?  14  Z7Z C C10 1 
HETATM 2498 C C11 . Z7Z D 2 14  ? -19.57598 -6.63439  -10.66743 1.000 26.61213 ?  14  Z7Z C C11 1 
HETATM 2499 C C12 . Z7Z D 2 14  ? -19.10092 -6.23168  -12.97247 1.000 25.49949 ?  14  Z7Z C C12 1 
HETATM 2500 C C13 . Z7Z D 2 14  ? -19.46756 -7.12142  -11.96818 1.000 26.14569 ?  14  Z7Z C C13 1 
HETATM 2501 N N   . PRS D 2 15  ? -19.98059 -9.42055  -11.36630 1.000 29.82301 ?  15  PRS C N   1 
HETATM 2502 C CD  . PRS D 2 15  ? -19.73854 -8.54158  -12.25791 1.000 28.28649 ?  15  PRS C CD  1 
HETATM 2503 C CA  . PRS D 2 15  ? -20.19783 -10.76294 -11.93969 1.000 32.72069 ?  15  PRS C CA  1 
HETATM 2504 C CB  . PRS D 2 15  ? -19.62918 -10.78675 -13.35958 1.000 27.78539 ?  15  PRS C CB  1 
HETATM 2505 S SG  . PRS D 2 15  ? -19.79645 -9.08336  -13.93274 1.000 29.17767 ?  15  PRS C SG  1 
HETATM 2506 C C   . PRS D 2 15  ? -19.44047 -11.79448 -11.11233 1.000 32.31023 ?  15  PRS C C   1 
HETATM 2507 O O   . PRS D 2 15  ? -19.52601 -12.95567 -11.39421 1.000 36.20446 ?  15  PRS C O   1 
HETATM 2508 O O   . HOH E 3 .   ? -9.13642  11.19436  -10.34542 1.000 44.89742 ?  201 HOH A O   1 
HETATM 2509 O O   . HOH E 3 .   ? -24.12356 -9.05341  -6.03826  1.000 41.42569 ?  202 HOH A O   1 
HETATM 2510 O O   . HOH E 3 .   ? -28.93860 4.76729   -18.84157 1.000 29.95266 ?  203 HOH A O   1 
HETATM 2511 O O   . HOH E 3 .   ? -21.76838 -14.28456 -14.24308 1.000 40.67573 ?  204 HOH A O   1 
HETATM 2512 O O   . HOH E 3 .   ? -11.48436 -15.69605 -37.15729 1.000 42.19444 ?  205 HOH A O   1 
HETATM 2513 O O   . HOH E 3 .   ? -21.35290 -17.12118 -17.30406 1.000 44.41753 ?  206 HOH A O   1 
HETATM 2514 O O   . HOH E 3 .   ? -13.22607 12.51524  -14.76738 1.000 38.64177 ?  207 HOH A O   1 
HETATM 2515 O O   . HOH E 3 .   ? -3.85951  8.33738   -27.10236 1.000 42.40580 ?  208 HOH A O   1 
HETATM 2516 O O   . HOH E 3 .   ? -17.08504 16.33481  -26.35652 1.000 34.86741 ?  209 HOH A O   1 
HETATM 2517 O O   . HOH E 3 .   ? -4.98314  5.59177   -29.71089 1.000 34.66041 ?  210 HOH A O   1 
HETATM 2518 O O   . HOH E 3 .   ? -5.80631  -4.59038  -46.30610 1.000 40.40899 ?  211 HOH A O   1 
HETATM 2519 O O   . HOH E 3 .   ? -13.76546 -15.14294 -8.91357  1.000 31.00367 ?  212 HOH A O   1 
HETATM 2520 O O   . HOH E 3 .   ? -24.58894 7.22229   -26.98961 1.000 35.14753 ?  213 HOH A O   1 
HETATM 2521 O O   . HOH E 3 .   ? -6.51015  -28.79569 -43.52921 1.000 37.67419 ?  214 HOH A O   1 
HETATM 2522 O O   . HOH E 3 .   ? -2.91125  1.20529   -15.77318 1.000 28.18248 ?  215 HOH A O   1 
HETATM 2523 O O   . HOH E 3 .   ? -3.48612  -6.60589  -22.75931 1.000 38.14166 ?  216 HOH A O   1 
HETATM 2524 O O   . HOH E 3 .   ? -8.94906  -17.11280 -43.23836 1.000 29.16663 ?  217 HOH A O   1 
HETATM 2525 O O   . HOH E 3 .   ? -27.71018 1.73103   -25.12681 1.000 31.16393 ?  218 HOH A O   1 
HETATM 2526 O O   . HOH E 3 .   ? -12.41689 1.68258   -35.18440 1.000 34.68492 ?  219 HOH A O   1 
HETATM 2527 O O   . HOH E 3 .   ? -30.58838 -5.46709  -17.73462 1.000 25.10125 ?  220 HOH A O   1 
HETATM 2528 O O   . HOH E 3 .   ? -8.59272  -3.25579  -47.44283 1.000 40.14892 ?  221 HOH A O   1 
HETATM 2529 O O   . HOH E 3 .   ? -7.32795  13.24554  -24.11173 1.000 43.33857 ?  222 HOH A O   1 
HETATM 2530 O O   . HOH E 3 .   ? -8.41904  -25.61457 -35.28760 1.000 37.37873 ?  223 HOH A O   1 
HETATM 2531 O O   . HOH E 3 .   ? -9.50542  8.09859   -12.62255 1.000 34.86289 ?  224 HOH A O   1 
HETATM 2532 O O   . HOH E 3 .   ? -21.67543 4.72873   -12.47081 1.000 32.85677 ?  225 HOH A O   1 
HETATM 2533 O O   . HOH E 3 .   ? -6.28058  8.21439   -23.38365 1.000 34.08992 ?  226 HOH A O   1 
HETATM 2534 O O   . HOH E 3 .   ? -7.05862  -17.26949 -21.68422 1.000 39.34531 ?  227 HOH A O   1 
HETATM 2535 O O   . HOH E 3 .   ? -12.07561 -18.74257 -10.23414 1.000 30.94729 ?  228 HOH A O   1 
HETATM 2536 O O   . HOH E 3 .   ? -13.81854 -18.41714 -21.21630 1.000 30.25921 ?  229 HOH A O   1 
HETATM 2537 O O   . HOH E 3 .   ? -25.02338 7.63782   -29.61733 1.000 35.59201 ?  230 HOH A O   1 
HETATM 2538 O O   . HOH E 3 .   ? -18.30620 7.54709   -14.56600 1.000 30.64908 ?  231 HOH A O   1 
HETATM 2539 O O   . HOH E 3 .   ? -18.33348 11.59305  -31.77166 1.000 25.76585 ?  232 HOH A O   1 
HETATM 2540 O O   . HOH E 3 .   ? 4.64220   -3.07595  -17.51705 1.000 33.82495 ?  233 HOH A O   1 
HETATM 2541 O O   . HOH E 3 .   ? -7.76439  3.30680   -31.19945 1.000 30.90921 ?  234 HOH A O   1 
HETATM 2542 O O   . HOH E 3 .   ? -20.86217 13.56123  -20.39159 1.000 39.75067 ?  235 HOH A O   1 
HETATM 2543 O O   . HOH E 3 .   ? -12.488   10.637    -32.419   1.000 35.74212 ?  236 HOH A O   1 
HETATM 2544 O O   . HOH E 3 .   ? -27.97553 -4.49831  -22.27328 1.000 36.63286 ?  237 HOH A O   1 
HETATM 2545 O O   . HOH E 3 .   ? -21.55486 2.03520   -12.40882 1.000 27.98225 ?  238 HOH A O   1 
HETATM 2546 O O   . HOH E 3 .   ? -23.94094 13.26101  -23.28538 1.000 38.46850 ?  239 HOH A O   1 
HETATM 2547 O O   . HOH E 3 .   ? -17.87211 13.95353  -20.19549 1.000 34.22003 ?  240 HOH A O   1 
HETATM 2548 O O   . HOH E 3 .   ? -2.61501  -13.23710 -19.67562 1.000 29.49381 ?  241 HOH A O   1 
HETATM 2549 O O   . HOH E 3 .   ? -23.59255 -3.17980  -23.42049 1.000 22.28108 ?  242 HOH A O   1 
HETATM 2550 O O   . HOH E 3 .   ? -8.03606  -14.44383 -36.10739 1.000 39.12366 ?  243 HOH A O   1 
HETATM 2551 O O   . HOH E 3 .   ? -2.558    -4.259    -9.076    1.000 42.19168 ?  244 HOH A O   1 
HETATM 2552 O O   . HOH E 3 .   ? -7.43388  5.47009   -10.81633 1.000 43.26168 ?  245 HOH A O   1 
HETATM 2553 O O   . HOH E 3 .   ? -6.00821  -9.44459  -10.76166 1.000 34.38378 ?  246 HOH A O   1 
HETATM 2554 O O   . HOH E 3 .   ? -19.10639 1.70219   -37.93915 1.000 34.78477 ?  247 HOH A O   1 
HETATM 2555 O O   . HOH E 3 .   ? -17.03081 19.16607  -31.21788 1.000 40.64335 ?  248 HOH A O   1 
HETATM 2556 O O   . HOH E 3 .   ? -24.13907 -14.76305 -21.09591 1.000 30.37658 ?  249 HOH A O   1 
HETATM 2557 O O   . HOH E 3 .   ? -13.02939 -20.21896 -19.21336 1.000 42.75067 ?  250 HOH A O   1 
HETATM 2558 O O   . HOH E 3 .   ? -5.35867  -1.70587  -8.33483  1.000 41.06832 ?  251 HOH A O   1 
HETATM 2559 O O   . HOH E 3 .   ? -8.38071  -29.60523 -45.56069 1.000 43.08815 ?  252 HOH A O   1 
HETATM 2560 O O   . HOH E 3 .   ? -9.60268  -6.86791  -9.84944  1.000 28.46299 ?  253 HOH A O   1 
HETATM 2561 O O   . HOH E 3 .   ? -26.91903 10.24516  -28.37511 1.000 44.85761 ?  254 HOH A O   1 
HETATM 2562 O O   . HOH E 3 .   ? -4.82856  -2.04722  -39.47102 1.000 47.14142 ?  255 HOH A O   1 
HETATM 2563 O O   . HOH E 3 .   ? -0.92599  -7.67397  -38.78063 1.000 42.48913 ?  256 HOH A O   1 
HETATM 2564 O O   . HOH E 3 .   ? -23.78278 -14.48633 -18.62121 1.000 31.37461 ?  257 HOH A O   1 
HETATM 2565 O O   . HOH E 3 .   ? -29.61190 -3.50709  -10.13973 1.000 25.33508 ?  258 HOH A O   1 
HETATM 2566 O O   . HOH E 3 .   ? -5.71909  0.87485   -9.40428  1.000 36.51075 ?  259 HOH A O   1 
HETATM 2567 O O   . HOH E 3 .   ? -27.710   9.745     -39.805   1.000 46.17360 ?  260 HOH A O   1 
HETATM 2568 O O   . HOH E 3 .   ? -13.60487 -31.64801 -38.65630 1.000 49.09659 ?  261 HOH A O   1 
HETATM 2569 O O   . HOH E 3 .   ? -21.14400 -16.00430 -26.23648 1.000 40.86115 ?  262 HOH A O   1 
HETATM 2570 O O   . HOH E 3 .   ? -9.79203  7.67146   -4.74360  1.000 41.96615 ?  263 HOH A O   1 
HETATM 2571 O O   . HOH E 3 .   ? -30.30674 -2.92391  -21.82335 1.000 45.82787 ?  264 HOH A O   1 
HETATM 2572 O O   . HOH E 3 .   ? -11.06140 -1.94939  -6.43424  1.000 30.18675 ?  265 HOH A O   1 
HETATM 2573 O O   . HOH E 3 .   ? -18.19575 -15.72712 -11.77371 1.000 34.41801 ?  266 HOH A O   1 
HETATM 2574 O O   . HOH E 3 .   ? -1.39962  -5.90034  -40.65312 1.000 41.57518 ?  267 HOH A O   1 
HETATM 2575 O O   . HOH E 3 .   ? -19.44866 6.44138   -12.61880 1.000 27.87473 ?  268 HOH A O   1 
HETATM 2576 O O   . HOH E 3 .   ? -1.34023  -7.82480  -20.77080 1.000 34.12184 ?  269 HOH A O   1 
HETATM 2577 O O   . HOH E 3 .   ? -4.91061  -4.89303  -8.11788  1.000 41.53808 ?  270 HOH A O   1 
HETATM 2578 O O   . HOH E 3 .   ? -26.19717 -13.50960 -17.17017 1.000 40.28004 ?  271 HOH A O   1 
HETATM 2579 O O   . HOH E 3 .   ? -0.86043  -15.00974 -15.51543 1.000 43.97184 ?  272 HOH A O   1 
HETATM 2580 O O   . HOH E 3 .   ? -28.12511 -11.80846 -18.98667 1.000 38.37279 ?  273 HOH A O   1 
HETATM 2581 O O   . HOH E 3 .   ? -33.600   -1.716    -21.943   1.000 42.35752 ?  274 HOH A O   1 
HETATM 2582 O O   . HOH E 3 .   ? -3.78892  -27.89345 -33.13415 1.000 43.62775 ?  275 HOH A O   1 
HETATM 2583 O O   . HOH E 3 .   ? -11.58285 -29.67378 -34.67570 1.000 43.90472 ?  276 HOH A O   1 
HETATM 2584 O O   . HOH E 3 .   ? -4.05294  -28.24990 -45.17265 1.000 31.20601 ?  277 HOH A O   1 
HETATM 2585 O O   . HOH E 3 .   ? -9.40135  -16.80465 -35.01343 1.000 49.99035 ?  278 HOH A O   1 
HETATM 2586 O O   . HOH E 3 .   ? -27.50467 -1.69673  -38.76334 1.000 52.73465 ?  279 HOH A O   1 
HETATM 2587 O O   . HOH E 3 .   ? -8.570    14.411    -25.529   1.000 38.35023 ?  280 HOH A O   1 
HETATM 2588 O O   . HOH E 3 .   ? -26.02159 -2.88267  -24.33564 1.000 28.29834 ?  281 HOH A O   1 
HETATM 2589 O O   . HOH E 3 .   ? -0.69400  -14.62057 -12.54806 1.000 41.29951 ?  282 HOH A O   1 
HETATM 2590 O O   . HOH E 3 .   ? -7.83597  -19.42853 -21.33963 1.000 41.65283 ?  283 HOH A O   1 
HETATM 2591 O O   . HOH E 3 .   ? -30.26302 -7.57539  -19.46257 1.000 35.36974 ?  284 HOH A O   1 
HETATM 2592 O O   . HOH E 3 .   ? -8.45493  1.41034   -32.80055 1.000 36.49845 ?  285 HOH A O   1 
HETATM 2593 O O   . HOH E 3 .   ? -3.57377  -30.13659 -32.47048 1.000 45.19697 ?  286 HOH A O   1 
HETATM 2594 O O   . HOH E 3 .   ? -28.17194 -1.23729  -24.44628 1.000 29.58321 ?  287 HOH A O   1 
HETATM 2595 O O   . HOH E 3 .   ? -7.69769  5.07724   -33.73693 1.000 44.67537 ?  288 HOH A O   1 
HETATM 2596 O O   . HOH F 3 .   ? -0.51674  -9.02675  -27.31741 1.000 43.48977 ?  201 HOH B O   1 
HETATM 2597 O O   . HOH F 3 .   ? -15.16164 -17.33093 -42.09305 1.000 39.39354 ?  202 HOH B O   1 
HETATM 2598 O O   . HOH F 3 .   ? 15.73835  -13.52737 -44.28118 1.000 34.66398 ?  203 HOH B O   1 
HETATM 2599 O O   . HOH F 3 .   ? 16.32165  -16.26498 -38.58102 1.000 30.63964 ?  204 HOH B O   1 
HETATM 2600 O O   . HOH F 3 .   ? 7.69114   -10.18971 -37.74444 1.000 25.84851 ?  205 HOH B O   1 
HETATM 2601 O O   . HOH F 3 .   ? 4.08921   -1.57866  -58.38733 1.000 42.84911 ?  206 HOH B O   1 
HETATM 2602 O O   . HOH F 3 .   ? 5.40358   -24.94569 -56.66167 1.000 39.49164 ?  207 HOH B O   1 
HETATM 2603 O O   . HOH F 3 .   ? 5.00290   -22.73341 -29.86031 1.000 45.64392 ?  208 HOH B O   1 
HETATM 2604 O O   . HOH F 3 .   ? 8.57714   -22.49685 -53.94215 1.000 36.08268 ?  209 HOH B O   1 
HETATM 2605 O O   . HOH F 3 .   ? -11.91014 -3.87036  -56.66857 1.000 37.39397 ?  210 HOH B O   1 
HETATM 2606 O O   . HOH F 3 .   ? 6.37799   -17.33320 -59.26981 1.000 36.70683 ?  211 HOH B O   1 
HETATM 2607 O O   . HOH F 3 .   ? -30.71003 -11.63675 -28.27163 1.000 34.89883 ?  212 HOH B O   1 
HETATM 2608 O O   . HOH F 3 .   ? 13.47599  -21.29680 -35.78372 1.000 32.10974 ?  213 HOH B O   1 
HETATM 2609 O O   . HOH F 3 .   ? 10.97912  -8.60423  -39.80492 1.000 29.96404 ?  214 HOH B O   1 
HETATM 2610 O O   . HOH F 3 .   ? -17.55626 -2.40719  -36.06441 1.000 35.98238 ?  215 HOH B O   1 
HETATM 2611 O O   . HOH F 3 .   ? -18.191   -21.049   -50.850   1.000 44.48620 ?  216 HOH B O   1 
HETATM 2612 O O   . HOH F 3 .   ? -21.80724 -8.73157  -22.92411 1.000 32.55237 ?  217 HOH B O   1 
HETATM 2613 O O   . HOH F 3 .   ? 2.09342   -23.86739 -31.40956 1.000 35.15450 ?  218 HOH B O   1 
HETATM 2614 O O   . HOH F 3 .   ? 2.81085   -38.85907 -37.91803 1.000 37.95244 ?  219 HOH B O   1 
HETATM 2615 O O   . HOH F 3 .   ? -5.67665  -6.94932  -57.61219 1.000 44.88627 ?  220 HOH B O   1 
HETATM 2616 O O   . HOH F 3 .   ? -12.84336 -16.41446 -52.62086 1.000 37.94449 ?  221 HOH B O   1 
HETATM 2617 O O   . HOH F 3 .   ? 5.20464   -6.46247  -51.92956 1.000 37.14107 ?  222 HOH B O   1 
HETATM 2618 O O   . HOH F 3 .   ? -15.90718 -10.20507 -25.99939 1.000 28.37178 ?  223 HOH B O   1 
HETATM 2619 O O   . HOH F 3 .   ? 16.76772  -23.69891 -41.38187 1.000 39.02707 ?  224 HOH B O   1 
HETATM 2620 O O   . HOH F 3 .   ? -11.88214 -9.50106  -32.63183 1.000 34.96600 ?  225 HOH B O   1 
HETATM 2621 O O   . HOH F 3 .   ? 17.98202  -21.29108 -45.42159 1.000 39.29847 ?  226 HOH B O   1 
HETATM 2622 O O   . HOH F 3 .   ? 7.12111   -8.11849  -39.80883 1.000 29.30721 ?  227 HOH B O   1 
HETATM 2623 O O   . HOH F 3 .   ? -16.39050 -7.86908  -42.82299 1.000 37.62980 ?  228 HOH B O   1 
HETATM 2624 O O   . HOH F 3 .   ? 11.23197  -24.27308 -36.52380 1.000 31.23918 ?  229 HOH B O   1 
HETATM 2625 O O   . HOH F 3 .   ? 10.96855  -10.92989 -44.02305 1.000 32.59821 ?  230 HOH B O   1 
HETATM 2626 O O   . HOH F 3 .   ? -3.67386  -25.79970 -46.11515 1.000 24.20110 ?  231 HOH B O   1 
HETATM 2627 O O   . HOH F 3 .   ? 15.74739  -16.51122 -47.00906 1.000 33.77522 ?  232 HOH B O   1 
HETATM 2628 O O   . HOH F 3 .   ? 14.01439  -18.28851 -37.39696 1.000 34.79267 ?  233 HOH B O   1 
HETATM 2629 O O   . HOH F 3 .   ? -16.41656 -12.95709 -48.44236 1.000 36.32084 ?  234 HOH B O   1 
HETATM 2630 O O   . HOH F 3 .   ? -33.634   -5.749    -35.063   1.000 26.61205 ?  235 HOH B O   1 
HETATM 2631 O O   . HOH F 3 .   ? 10.75373  -13.23462 -62.71970 1.000 32.00118 ?  236 HOH B O   1 
HETATM 2632 O O   . HOH F 3 .   ? -28.61335 -9.90852  -34.76681 1.000 40.30033 ?  237 HOH B O   1 
HETATM 2633 O O   . HOH F 3 .   ? 4.91879   -8.52997  -58.39147 1.000 33.61384 ?  238 HOH B O   1 
HETATM 2634 O O   . HOH F 3 .   ? -3.73327  -10.59866 -58.62732 1.000 33.45920 ?  239 HOH B O   1 
HETATM 2635 O O   . HOH F 3 .   ? 3.66849   -32.86741 -51.08208 1.000 38.77752 ?  240 HOH B O   1 
HETATM 2636 O O   . HOH F 3 .   ? -15.46705 -15.08567 -41.34551 1.000 40.20158 ?  241 HOH B O   1 
HETATM 2637 O O   . HOH F 3 .   ? -24.77268 -11.92142 -29.79221 1.000 34.72387 ?  242 HOH B O   1 
HETATM 2638 O O   . HOH F 3 .   ? -15.90195 -21.06640 -43.06432 1.000 38.91028 ?  243 HOH B O   1 
HETATM 2639 O O   . HOH F 3 .   ? -3.81007  -31.21195 -60.07928 1.000 44.82107 ?  244 HOH B O   1 
HETATM 2640 O O   . HOH F 3 .   ? 6.73443   -11.54049 -64.76137 1.000 31.69885 ?  245 HOH B O   1 
HETATM 2641 O O   . HOH F 3 .   ? 18.59365  -18.18394 -49.69997 1.000 41.86096 ?  246 HOH B O   1 
HETATM 2642 O O   . HOH F 3 .   ? 0.89374   -12.60965 -61.90295 1.000 34.31086 ?  247 HOH B O   1 
HETATM 2643 O O   . HOH F 3 .   ? 15.23036  -16.46848 -51.54714 1.000 36.58966 ?  248 HOH B O   1 
HETATM 2644 O O   . HOH F 3 .   ? -6.09773  -29.73229 -47.52258 1.000 45.11842 ?  249 HOH B O   1 
HETATM 2645 O O   . HOH F 3 .   ? 8.00021   -19.89364 -59.61098 1.000 40.88439 ?  250 HOH B O   1 
HETATM 2646 O O   . HOH F 3 .   ? -27.86697 -4.39192  -38.59191 1.000 46.63831 ?  251 HOH B O   1 
HETATM 2647 O O   . HOH F 3 .   ? -31.937   -3.871    -37.580   1.000 52.24370 ?  252 HOH B O   1 
HETATM 2648 O O   . HOH F 3 .   ? -16.88911 -14.73580 -49.78632 1.000 36.24387 ?  253 HOH B O   1 
HETATM 2649 O O   . HOH F 3 .   ? 0.63393   -5.69570  -38.23225 1.000 40.82778 ?  254 HOH B O   1 
HETATM 2650 O O   . HOH F 3 .   ? -2.10016  -27.35973 -31.30822 1.000 47.62724 ?  255 HOH B O   1 
HETATM 2651 O O   . HOH F 3 .   ? -15.30633 -14.58900 -39.00257 1.000 50.35858 ?  256 HOH B O   1 
HETATM 2652 O O   . HOH F 3 .   ? 5.51964   -6.51853  -56.31243 1.000 42.66877 ?  257 HOH B O   1 
HETATM 2653 O O   . HOH G 3 .   ? -10.45480 -14.62939 -66.08670 1.000 31.38093 ?  101 HOH D O   1 
HETATM 2654 O O   . HOH G 3 .   ? -6.70439  -20.46266 -67.21621 1.000 39.62236 ?  102 HOH D O   1 
HETATM 2655 O O   . HOH G 3 .   ? -12.32083 -12.94935 -62.33107 1.000 27.93503 ?  103 HOH D O   1 
HETATM 2656 O O   . HOH G 3 .   ? 2.12392   -19.78859 -67.30949 1.000 46.31719 ?  104 HOH D O   1 
HETATM 2657 O O   . HOH G 3 .   ? 2.59075   -24.05123 -56.73206 1.000 36.26339 ?  105 HOH D O   1 
HETATM 2658 O O   . HOH H 3 .   ? -26.64853 -2.46217  -9.63055  1.000 29.64465 ?  101 HOH C O   1 
HETATM 2659 O O   . HOH H 3 .   ? -10.31045 -9.25774  -8.79169  1.000 28.94790 ?  102 HOH C O   1 
HETATM 2660 O O   . HOH H 3 .   ? -12.420   -6.392    -6.955    1.000 36.19500 ?  103 HOH C O   1 
HETATM 2661 O O   . HOH H 3 .   ? -18.17758 -16.29276 -9.62621  1.000 42.01177 ?  104 HOH C O   1 
# 
