data_8ZE8
# 
_entry.id   8ZE8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8ZE8         pdb_00008ze8 10.2210/pdb8ze8/pdb 
WWPDB D_1300047579 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8ZE8 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              zhangmj@sustech.edu.cn 
_pdbx_contact_author.name_first         Mingjie 
_pdbx_contact_author.name_last          Zhang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9404-0190 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Chen, K.'  1 ? 
'Li, Y.'    2 ? 
'Zhao, Y.'  3 ? 
'He, Y.'    4 ? 
'Zhang, M.' 5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Arf GTPase-activating protein ASAP1 specifically binds to 440-kD ankyrin-B' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Li, Y.'    1 ? 
primary 'Zhao, Y.'  2 ? 
primary 'He, Y.'    3 ? 
primary 'Liu, F.'   4 ? 
primary 'Xia, L.'   5 ? 
primary 'Liu, K.'   6 ? 
primary 'Chen, K.'  7 ? 
primary 'Zhang, M.' 8 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1' 7794.611 4   ? ? ? ? 
2 polymer     syn Ankyrin-2                                                                1457.849 4   ? ? ? ? 
3 non-polymer syn GLYCEROL                                                                 92.094   1   ? ? ? ? 
4 water       nat water                                                                    18.015   310 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein,ADP-ribosylation factor-directed GTPase-activating protein 1,ARF GTPase-activating protein 1,Development and differentiation-enhancing factor 1,DEF-1,Differentiation-enhancing factor 1,PIP2-dependent ARF1 GAP
;
2 'ANK-2,Ankyrin-B,Brain ankyrin,Non-erythroid ankyrin' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no GPGSGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 
GPGSGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD A,B,D,G ? 
2 'polypeptide(L)' no no GIKKPVRRKLKE                                                          GIKKPVRRKLKE E,C,F,H ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 GLYCEROL GOL 
4 water    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  GLY n 
1 2  PRO n 
1 3  GLY n 
1 4  SER n 
1 5  GLY n 
1 6  LYS n 
1 7  ASN n 
1 8  LYS n 
1 9  VAL n 
1 10 ARG n 
1 11 ARG n 
1 12 VAL n 
1 13 LYS n 
1 14 THR n 
1 15 ILE n 
1 16 TYR n 
1 17 ASP n 
1 18 CYS n 
1 19 GLN n 
1 20 ALA n 
1 21 ASP n 
1 22 ASN n 
1 23 ASP n 
1 24 ASP n 
1 25 GLU n 
1 26 LEU n 
1 27 THR n 
1 28 PHE n 
1 29 ILE n 
1 30 GLU n 
1 31 GLY n 
1 32 GLU n 
1 33 VAL n 
1 34 ILE n 
1 35 ILE n 
1 36 VAL n 
1 37 THR n 
1 38 GLY n 
1 39 GLU n 
1 40 GLU n 
1 41 ASP n 
1 42 GLN n 
1 43 GLU n 
1 44 TRP n 
1 45 TRP n 
1 46 ILE n 
1 47 GLY n 
1 48 HIS n 
1 49 ILE n 
1 50 GLU n 
1 51 GLY n 
1 52 GLN n 
1 53 PRO n 
1 54 GLU n 
1 55 ARG n 
1 56 LYS n 
1 57 GLY n 
1 58 VAL n 
1 59 PHE n 
1 60 PRO n 
1 61 VAL n 
1 62 SER n 
1 63 PHE n 
1 64 VAL n 
1 65 HIS n 
1 66 ILE n 
1 67 LEU n 
1 68 SER n 
1 69 ASP n 
2 1  GLY n 
2 2  ILE n 
2 3  LYS n 
2 4  LYS n 
2 5  PRO n 
2 6  VAL n 
2 7  ARG n 
2 8  ARG n 
2 9  LYS n 
2 10 LEU n 
2 11 LYS n 
2 12 GLU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   69 
_entity_src_gen.gene_src_common_name               'house mouse' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'Asap1, Ddef1, Kiaa1249, Shag1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Mus musculus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     10090 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       12 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  GLY 1  1079 ?    ?   ?   A . n 
A 1 2  PRO 2  1080 ?    ?   ?   A . n 
A 1 3  GLY 3  1081 ?    ?   ?   A . n 
A 1 4  SER 4  1082 ?    ?   ?   A . n 
A 1 5  GLY 5  1083 ?    ?   ?   A . n 
A 1 6  LYS 6  1084 ?    ?   ?   A . n 
A 1 7  ASN 7  1085 ?    ?   ?   A . n 
A 1 8  LYS 8  1086 1086 LYS LYS A . n 
A 1 9  VAL 9  1087 1087 VAL VAL A . n 
A 1 10 ARG 10 1088 1088 ARG ARG A . n 
A 1 11 ARG 11 1089 1089 ARG ARG A . n 
A 1 12 VAL 12 1090 1090 VAL VAL A . n 
A 1 13 LYS 13 1091 1091 LYS LYS A . n 
A 1 14 THR 14 1092 1092 THR THR A . n 
A 1 15 ILE 15 1093 1093 ILE ILE A . n 
A 1 16 TYR 16 1094 1094 TYR TYR A . n 
A 1 17 ASP 17 1095 1095 ASP ASP A . n 
A 1 18 CYS 18 1096 1096 CYS CYS A . n 
A 1 19 GLN 19 1097 1097 GLN GLN A . n 
A 1 20 ALA 20 1098 1098 ALA ALA A . n 
A 1 21 ASP 21 1099 1099 ASP ASP A . n 
A 1 22 ASN 22 1100 1100 ASN ASN A . n 
A 1 23 ASP 23 1101 1101 ASP ASP A . n 
A 1 24 ASP 24 1102 1102 ASP ASP A . n 
A 1 25 GLU 25 1103 1103 GLU GLU A . n 
A 1 26 LEU 26 1104 1104 LEU LEU A . n 
A 1 27 THR 27 1105 1105 THR THR A . n 
A 1 28 PHE 28 1106 1106 PHE PHE A . n 
A 1 29 ILE 29 1107 1107 ILE ILE A . n 
A 1 30 GLU 30 1108 1108 GLU GLU A . n 
A 1 31 GLY 31 1109 1109 GLY GLY A . n 
A 1 32 GLU 32 1110 1110 GLU GLU A . n 
A 1 33 VAL 33 1111 1111 VAL VAL A . n 
A 1 34 ILE 34 1112 1112 ILE ILE A . n 
A 1 35 ILE 35 1113 1113 ILE ILE A . n 
A 1 36 VAL 36 1114 1114 VAL VAL A . n 
A 1 37 THR 37 1115 1115 THR THR A . n 
A 1 38 GLY 38 1116 1116 GLY GLY A . n 
A 1 39 GLU 39 1117 1117 GLU GLU A . n 
A 1 40 GLU 40 1118 1118 GLU GLU A . n 
A 1 41 ASP 41 1119 1119 ASP ASP A . n 
A 1 42 GLN 42 1120 1120 GLN GLN A . n 
A 1 43 GLU 43 1121 1121 GLU GLU A . n 
A 1 44 TRP 44 1122 1122 TRP TRP A . n 
A 1 45 TRP 45 1123 1123 TRP TRP A . n 
A 1 46 ILE 46 1124 1124 ILE ILE A . n 
A 1 47 GLY 47 1125 1125 GLY GLY A . n 
A 1 48 HIS 48 1126 1126 HIS HIS A . n 
A 1 49 ILE 49 1127 1127 ILE ILE A . n 
A 1 50 GLU 50 1128 1128 GLU GLU A . n 
A 1 51 GLY 51 1129 1129 GLY GLY A . n 
A 1 52 GLN 52 1130 1130 GLN GLN A . n 
A 1 53 PRO 53 1131 1131 PRO PRO A . n 
A 1 54 GLU 54 1132 1132 GLU GLU A . n 
A 1 55 ARG 55 1133 1133 ARG ARG A . n 
A 1 56 LYS 56 1134 1134 LYS LYS A . n 
A 1 57 GLY 57 1135 1135 GLY GLY A . n 
A 1 58 VAL 58 1136 1136 VAL VAL A . n 
A 1 59 PHE 59 1137 1137 PHE PHE A . n 
A 1 60 PRO 60 1138 1138 PRO PRO A . n 
A 1 61 VAL 61 1139 1139 VAL VAL A . n 
A 1 62 SER 62 1140 1140 SER SER A . n 
A 1 63 PHE 63 1141 1141 PHE PHE A . n 
A 1 64 VAL 64 1142 1142 VAL VAL A . n 
A 1 65 HIS 65 1143 1143 HIS HIS A . n 
A 1 66 ILE 66 1144 1144 ILE ILE A . n 
A 1 67 LEU 67 1145 1145 LEU LEU A . n 
A 1 68 SER 68 1146 1146 SER SER A . n 
A 1 69 ASP 69 1147 1147 ASP ASP A . n 
B 2 1  GLY 1  1699 ?    ?   ?   E . n 
B 2 2  ILE 2  1700 1700 ILE ILE E . n 
B 2 3  LYS 3  1701 1701 LYS LYS E . n 
B 2 4  LYS 4  1702 1702 LYS LYS E . n 
B 2 5  PRO 5  1703 1703 PRO PRO E . n 
B 2 6  VAL 6  1704 1704 VAL VAL E . n 
B 2 7  ARG 7  1705 1705 ARG ARG E . n 
B 2 8  ARG 8  1706 1706 ARG ARG E . n 
B 2 9  LYS 9  1707 ?    ?   ?   E . n 
B 2 10 LEU 10 1708 ?    ?   ?   E . n 
B 2 11 LYS 11 1709 ?    ?   ?   E . n 
B 2 12 GLU 12 1710 ?    ?   ?   E . n 
C 1 1  GLY 1  1079 ?    ?   ?   B . n 
C 1 2  PRO 2  1080 ?    ?   ?   B . n 
C 1 3  GLY 3  1081 ?    ?   ?   B . n 
C 1 4  SER 4  1082 ?    ?   ?   B . n 
C 1 5  GLY 5  1083 ?    ?   ?   B . n 
C 1 6  LYS 6  1084 ?    ?   ?   B . n 
C 1 7  ASN 7  1085 ?    ?   ?   B . n 
C 1 8  LYS 8  1086 1086 LYS LYS B . n 
C 1 9  VAL 9  1087 1087 VAL VAL B . n 
C 1 10 ARG 10 1088 1088 ARG ARG B . n 
C 1 11 ARG 11 1089 1089 ARG ARG B . n 
C 1 12 VAL 12 1090 1090 VAL VAL B . n 
C 1 13 LYS 13 1091 1091 LYS LYS B . n 
C 1 14 THR 14 1092 1092 THR THR B . n 
C 1 15 ILE 15 1093 1093 ILE ILE B . n 
C 1 16 TYR 16 1094 1094 TYR TYR B . n 
C 1 17 ASP 17 1095 1095 ASP ASP B . n 
C 1 18 CYS 18 1096 1096 CYS CYS B . n 
C 1 19 GLN 19 1097 1097 GLN GLN B . n 
C 1 20 ALA 20 1098 1098 ALA ALA B . n 
C 1 21 ASP 21 1099 1099 ASP ASP B . n 
C 1 22 ASN 22 1100 1100 ASN ASN B . n 
C 1 23 ASP 23 1101 1101 ASP ASP B . n 
C 1 24 ASP 24 1102 1102 ASP ASP B . n 
C 1 25 GLU 25 1103 1103 GLU GLU B . n 
C 1 26 LEU 26 1104 1104 LEU LEU B . n 
C 1 27 THR 27 1105 1105 THR THR B . n 
C 1 28 PHE 28 1106 1106 PHE PHE B . n 
C 1 29 ILE 29 1107 1107 ILE ILE B . n 
C 1 30 GLU 30 1108 1108 GLU GLU B . n 
C 1 31 GLY 31 1109 1109 GLY GLY B . n 
C 1 32 GLU 32 1110 1110 GLU GLU B . n 
C 1 33 VAL 33 1111 1111 VAL VAL B . n 
C 1 34 ILE 34 1112 1112 ILE ILE B . n 
C 1 35 ILE 35 1113 1113 ILE ILE B . n 
C 1 36 VAL 36 1114 1114 VAL VAL B . n 
C 1 37 THR 37 1115 1115 THR THR B . n 
C 1 38 GLY 38 1116 1116 GLY GLY B . n 
C 1 39 GLU 39 1117 1117 GLU GLU B . n 
C 1 40 GLU 40 1118 1118 GLU GLU B . n 
C 1 41 ASP 41 1119 1119 ASP ASP B . n 
C 1 42 GLN 42 1120 1120 GLN GLN B . n 
C 1 43 GLU 43 1121 1121 GLU GLU B . n 
C 1 44 TRP 44 1122 1122 TRP TRP B . n 
C 1 45 TRP 45 1123 1123 TRP TRP B . n 
C 1 46 ILE 46 1124 1124 ILE ILE B . n 
C 1 47 GLY 47 1125 1125 GLY GLY B . n 
C 1 48 HIS 48 1126 1126 HIS HIS B . n 
C 1 49 ILE 49 1127 1127 ILE ILE B . n 
C 1 50 GLU 50 1128 1128 GLU GLU B . n 
C 1 51 GLY 51 1129 1129 GLY GLY B . n 
C 1 52 GLN 52 1130 1130 GLN GLN B . n 
C 1 53 PRO 53 1131 1131 PRO PRO B . n 
C 1 54 GLU 54 1132 1132 GLU GLU B . n 
C 1 55 ARG 55 1133 1133 ARG ARG B . n 
C 1 56 LYS 56 1134 1134 LYS LYS B . n 
C 1 57 GLY 57 1135 1135 GLY GLY B . n 
C 1 58 VAL 58 1136 1136 VAL VAL B . n 
C 1 59 PHE 59 1137 1137 PHE PHE B . n 
C 1 60 PRO 60 1138 1138 PRO PRO B . n 
C 1 61 VAL 61 1139 1139 VAL VAL B . n 
C 1 62 SER 62 1140 1140 SER SER B . n 
C 1 63 PHE 63 1141 1141 PHE PHE B . n 
C 1 64 VAL 64 1142 1142 VAL VAL B . n 
C 1 65 HIS 65 1143 1143 HIS HIS B . n 
C 1 66 ILE 66 1144 1144 ILE ILE B . n 
C 1 67 LEU 67 1145 1145 LEU LEU B . n 
C 1 68 SER 68 1146 1146 SER SER B . n 
C 1 69 ASP 69 1147 1147 ASP ASP B . n 
D 2 1  GLY 1  1699 ?    ?   ?   C . n 
D 2 2  ILE 2  1700 1700 ILE ILE C . n 
D 2 3  LYS 3  1701 1701 LYS LYS C . n 
D 2 4  LYS 4  1702 1702 LYS LYS C . n 
D 2 5  PRO 5  1703 1703 PRO PRO C . n 
D 2 6  VAL 6  1704 1704 VAL VAL C . n 
D 2 7  ARG 7  1705 1705 ARG ARG C . n 
D 2 8  ARG 8  1706 1706 ARG ARG C . n 
D 2 9  LYS 9  1707 ?    ?   ?   C . n 
D 2 10 LEU 10 1708 ?    ?   ?   C . n 
D 2 11 LYS 11 1709 ?    ?   ?   C . n 
D 2 12 GLU 12 1710 ?    ?   ?   C . n 
E 1 1  GLY 1  1079 ?    ?   ?   D . n 
E 1 2  PRO 2  1080 ?    ?   ?   D . n 
E 1 3  GLY 3  1081 ?    ?   ?   D . n 
E 1 4  SER 4  1082 ?    ?   ?   D . n 
E 1 5  GLY 5  1083 ?    ?   ?   D . n 
E 1 6  LYS 6  1084 ?    ?   ?   D . n 
E 1 7  ASN 7  1085 ?    ?   ?   D . n 
E 1 8  LYS 8  1086 1086 LYS LYS D . n 
E 1 9  VAL 9  1087 1087 VAL VAL D . n 
E 1 10 ARG 10 1088 1088 ARG ARG D . n 
E 1 11 ARG 11 1089 1089 ARG ARG D . n 
E 1 12 VAL 12 1090 1090 VAL VAL D . n 
E 1 13 LYS 13 1091 1091 LYS LYS D . n 
E 1 14 THR 14 1092 1092 THR THR D . n 
E 1 15 ILE 15 1093 1093 ILE ILE D . n 
E 1 16 TYR 16 1094 1094 TYR TYR D . n 
E 1 17 ASP 17 1095 1095 ASP ASP D . n 
E 1 18 CYS 18 1096 1096 CYS CYS D . n 
E 1 19 GLN 19 1097 1097 GLN GLN D . n 
E 1 20 ALA 20 1098 1098 ALA ALA D . n 
E 1 21 ASP 21 1099 1099 ASP ASP D . n 
E 1 22 ASN 22 1100 1100 ASN ASN D . n 
E 1 23 ASP 23 1101 1101 ASP ASP D . n 
E 1 24 ASP 24 1102 1102 ASP ASP D . n 
E 1 25 GLU 25 1103 1103 GLU GLU D . n 
E 1 26 LEU 26 1104 1104 LEU LEU D . n 
E 1 27 THR 27 1105 1105 THR THR D . n 
E 1 28 PHE 28 1106 1106 PHE PHE D . n 
E 1 29 ILE 29 1107 1107 ILE ILE D . n 
E 1 30 GLU 30 1108 1108 GLU GLU D . n 
E 1 31 GLY 31 1109 1109 GLY GLY D . n 
E 1 32 GLU 32 1110 1110 GLU GLU D . n 
E 1 33 VAL 33 1111 1111 VAL VAL D . n 
E 1 34 ILE 34 1112 1112 ILE ILE D . n 
E 1 35 ILE 35 1113 1113 ILE ILE D . n 
E 1 36 VAL 36 1114 1114 VAL VAL D . n 
E 1 37 THR 37 1115 1115 THR THR D . n 
E 1 38 GLY 38 1116 1116 GLY GLY D . n 
E 1 39 GLU 39 1117 1117 GLU GLU D . n 
E 1 40 GLU 40 1118 1118 GLU GLU D . n 
E 1 41 ASP 41 1119 1119 ASP ASP D . n 
E 1 42 GLN 42 1120 1120 GLN GLN D . n 
E 1 43 GLU 43 1121 1121 GLU GLU D . n 
E 1 44 TRP 44 1122 1122 TRP TRP D . n 
E 1 45 TRP 45 1123 1123 TRP TRP D . n 
E 1 46 ILE 46 1124 1124 ILE ILE D . n 
E 1 47 GLY 47 1125 1125 GLY GLY D . n 
E 1 48 HIS 48 1126 1126 HIS HIS D . n 
E 1 49 ILE 49 1127 1127 ILE ILE D . n 
E 1 50 GLU 50 1128 1128 GLU GLU D . n 
E 1 51 GLY 51 1129 1129 GLY GLY D . n 
E 1 52 GLN 52 1130 1130 GLN GLN D . n 
E 1 53 PRO 53 1131 1131 PRO PRO D . n 
E 1 54 GLU 54 1132 1132 GLU GLU D . n 
E 1 55 ARG 55 1133 1133 ARG ARG D . n 
E 1 56 LYS 56 1134 1134 LYS LYS D . n 
E 1 57 GLY 57 1135 1135 GLY GLY D . n 
E 1 58 VAL 58 1136 1136 VAL VAL D . n 
E 1 59 PHE 59 1137 1137 PHE PHE D . n 
E 1 60 PRO 60 1138 1138 PRO PRO D . n 
E 1 61 VAL 61 1139 1139 VAL VAL D . n 
E 1 62 SER 62 1140 1140 SER SER D . n 
E 1 63 PHE 63 1141 1141 PHE PHE D . n 
E 1 64 VAL 64 1142 1142 VAL VAL D . n 
E 1 65 HIS 65 1143 1143 HIS HIS D . n 
E 1 66 ILE 66 1144 1144 ILE ILE D . n 
E 1 67 LEU 67 1145 1145 LEU LEU D . n 
E 1 68 SER 68 1146 1146 SER SER D . n 
E 1 69 ASP 69 1147 ?    ?   ?   D . n 
F 2 1  GLY 1  1699 ?    ?   ?   F . n 
F 2 2  ILE 2  1700 1700 ILE ILE F . n 
F 2 3  LYS 3  1701 1701 LYS LYS F . n 
F 2 4  LYS 4  1702 1702 LYS LYS F . n 
F 2 5  PRO 5  1703 1703 PRO PRO F . n 
F 2 6  VAL 6  1704 1704 VAL VAL F . n 
F 2 7  ARG 7  1705 1705 ARG ARG F . n 
F 2 8  ARG 8  1706 1706 ARG ARG F . n 
F 2 9  LYS 9  1707 ?    ?   ?   F . n 
F 2 10 LEU 10 1708 ?    ?   ?   F . n 
F 2 11 LYS 11 1709 ?    ?   ?   F . n 
F 2 12 GLU 12 1710 ?    ?   ?   F . n 
G 1 1  GLY 1  1079 ?    ?   ?   G . n 
G 1 2  PRO 2  1080 ?    ?   ?   G . n 
G 1 3  GLY 3  1081 ?    ?   ?   G . n 
G 1 4  SER 4  1082 ?    ?   ?   G . n 
G 1 5  GLY 5  1083 ?    ?   ?   G . n 
G 1 6  LYS 6  1084 ?    ?   ?   G . n 
G 1 7  ASN 7  1085 ?    ?   ?   G . n 
G 1 8  LYS 8  1086 1086 LYS LYS G . n 
G 1 9  VAL 9  1087 1087 VAL VAL G . n 
G 1 10 ARG 10 1088 1088 ARG ARG G . n 
G 1 11 ARG 11 1089 1089 ARG ARG G . n 
G 1 12 VAL 12 1090 1090 VAL VAL G . n 
G 1 13 LYS 13 1091 1091 LYS LYS G . n 
G 1 14 THR 14 1092 1092 THR THR G . n 
G 1 15 ILE 15 1093 1093 ILE ILE G . n 
G 1 16 TYR 16 1094 1094 TYR TYR G . n 
G 1 17 ASP 17 1095 1095 ASP ASP G . n 
G 1 18 CYS 18 1096 1096 CYS CYS G . n 
G 1 19 GLN 19 1097 1097 GLN GLN G . n 
G 1 20 ALA 20 1098 1098 ALA ALA G . n 
G 1 21 ASP 21 1099 1099 ASP ASP G . n 
G 1 22 ASN 22 1100 1100 ASN ASN G . n 
G 1 23 ASP 23 1101 1101 ASP ASP G . n 
G 1 24 ASP 24 1102 1102 ASP ASP G . n 
G 1 25 GLU 25 1103 1103 GLU GLU G . n 
G 1 26 LEU 26 1104 1104 LEU LEU G . n 
G 1 27 THR 27 1105 1105 THR THR G . n 
G 1 28 PHE 28 1106 1106 PHE PHE G . n 
G 1 29 ILE 29 1107 1107 ILE ILE G . n 
G 1 30 GLU 30 1108 1108 GLU GLU G . n 
G 1 31 GLY 31 1109 1109 GLY GLY G . n 
G 1 32 GLU 32 1110 1110 GLU GLU G . n 
G 1 33 VAL 33 1111 1111 VAL VAL G . n 
G 1 34 ILE 34 1112 1112 ILE ILE G . n 
G 1 35 ILE 35 1113 1113 ILE ILE G . n 
G 1 36 VAL 36 1114 1114 VAL VAL G . n 
G 1 37 THR 37 1115 1115 THR THR G . n 
G 1 38 GLY 38 1116 1116 GLY GLY G . n 
G 1 39 GLU 39 1117 1117 GLU GLU G . n 
G 1 40 GLU 40 1118 1118 GLU GLU G . n 
G 1 41 ASP 41 1119 1119 ASP ASP G . n 
G 1 42 GLN 42 1120 1120 GLN GLN G . n 
G 1 43 GLU 43 1121 1121 GLU GLU G . n 
G 1 44 TRP 44 1122 1122 TRP TRP G . n 
G 1 45 TRP 45 1123 1123 TRP TRP G . n 
G 1 46 ILE 46 1124 1124 ILE ILE G . n 
G 1 47 GLY 47 1125 1125 GLY GLY G . n 
G 1 48 HIS 48 1126 1126 HIS HIS G . n 
G 1 49 ILE 49 1127 1127 ILE ILE G . n 
G 1 50 GLU 50 1128 1128 GLU GLU G . n 
G 1 51 GLY 51 1129 1129 GLY GLY G . n 
G 1 52 GLN 52 1130 1130 GLN GLN G . n 
G 1 53 PRO 53 1131 1131 PRO PRO G . n 
G 1 54 GLU 54 1132 1132 GLU GLU G . n 
G 1 55 ARG 55 1133 1133 ARG ARG G . n 
G 1 56 LYS 56 1134 1134 LYS LYS G . n 
G 1 57 GLY 57 1135 1135 GLY GLY G . n 
G 1 58 VAL 58 1136 1136 VAL VAL G . n 
G 1 59 PHE 59 1137 1137 PHE PHE G . n 
G 1 60 PRO 60 1138 1138 PRO PRO G . n 
G 1 61 VAL 61 1139 1139 VAL VAL G . n 
G 1 62 SER 62 1140 1140 SER SER G . n 
G 1 63 PHE 63 1141 1141 PHE PHE G . n 
G 1 64 VAL 64 1142 1142 VAL VAL G . n 
G 1 65 HIS 65 1143 1143 HIS HIS G . n 
G 1 66 ILE 66 1144 1144 ILE ILE G . n 
G 1 67 LEU 67 1145 1145 LEU LEU G . n 
G 1 68 SER 68 1146 1146 SER SER G . n 
G 1 69 ASP 69 1147 ?    ?   ?   G . n 
H 2 1  GLY 1  1699 ?    ?   ?   H . n 
H 2 2  ILE 2  1700 1700 ILE ILE H . n 
H 2 3  LYS 3  1701 1701 LYS LYS H . n 
H 2 4  LYS 4  1702 1702 LYS LYS H . n 
H 2 5  PRO 5  1703 1703 PRO PRO H . n 
H 2 6  VAL 6  1704 1704 VAL VAL H . n 
H 2 7  ARG 7  1705 1705 ARG ARG H . n 
H 2 8  ARG 8  1706 1706 ARG ARG H . n 
H 2 9  LYS 9  1707 ?    ?   ?   H . n 
H 2 10 LEU 10 1708 ?    ?   ?   H . n 
H 2 11 LYS 11 1709 ?    ?   ?   H . n 
H 2 12 GLU 12 1710 ?    ?   ?   H . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        GOL 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   GOL 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
I 3 GOL 1  1201 330 GOL GOL B . 
J 4 HOH 1  1201 164 HOH HOH A . 
J 4 HOH 2  1202 221 HOH HOH A . 
J 4 HOH 3  1203 231 HOH HOH A . 
J 4 HOH 4  1204 6   HOH HOH A . 
J 4 HOH 5  1205 92  HOH HOH A . 
J 4 HOH 6  1206 181 HOH HOH A . 
J 4 HOH 7  1207 140 HOH HOH A . 
J 4 HOH 8  1208 115 HOH HOH A . 
J 4 HOH 9  1209 287 HOH HOH A . 
J 4 HOH 10 1210 42  HOH HOH A . 
J 4 HOH 11 1211 13  HOH HOH A . 
J 4 HOH 12 1212 71  HOH HOH A . 
J 4 HOH 13 1213 29  HOH HOH A . 
J 4 HOH 14 1214 23  HOH HOH A . 
J 4 HOH 15 1215 121 HOH HOH A . 
J 4 HOH 16 1216 26  HOH HOH A . 
J 4 HOH 17 1217 39  HOH HOH A . 
J 4 HOH 18 1218 52  HOH HOH A . 
J 4 HOH 19 1219 88  HOH HOH A . 
J 4 HOH 20 1220 171 HOH HOH A . 
J 4 HOH 21 1221 66  HOH HOH A . 
J 4 HOH 22 1222 5   HOH HOH A . 
J 4 HOH 23 1223 58  HOH HOH A . 
J 4 HOH 24 1224 174 HOH HOH A . 
J 4 HOH 25 1225 1   HOH HOH A . 
J 4 HOH 26 1226 204 HOH HOH A . 
J 4 HOH 27 1227 9   HOH HOH A . 
J 4 HOH 28 1228 127 HOH HOH A . 
J 4 HOH 29 1229 60  HOH HOH A . 
J 4 HOH 30 1230 97  HOH HOH A . 
J 4 HOH 31 1231 54  HOH HOH A . 
J 4 HOH 32 1232 184 HOH HOH A . 
J 4 HOH 33 1233 43  HOH HOH A . 
J 4 HOH 34 1234 167 HOH HOH A . 
J 4 HOH 35 1235 91  HOH HOH A . 
J 4 HOH 36 1236 79  HOH HOH A . 
J 4 HOH 37 1237 198 HOH HOH A . 
J 4 HOH 38 1238 190 HOH HOH A . 
J 4 HOH 39 1239 113 HOH HOH A . 
J 4 HOH 40 1240 180 HOH HOH A . 
J 4 HOH 41 1241 266 HOH HOH A . 
J 4 HOH 42 1242 47  HOH HOH A . 
J 4 HOH 43 1243 208 HOH HOH A . 
J 4 HOH 44 1244 130 HOH HOH A . 
J 4 HOH 45 1245 238 HOH HOH A . 
J 4 HOH 46 1246 108 HOH HOH A . 
J 4 HOH 47 1247 306 HOH HOH A . 
J 4 HOH 48 1248 107 HOH HOH A . 
J 4 HOH 49 1249 49  HOH HOH A . 
J 4 HOH 50 1250 296 HOH HOH A . 
J 4 HOH 51 1251 123 HOH HOH A . 
J 4 HOH 52 1252 134 HOH HOH A . 
J 4 HOH 53 1253 95  HOH HOH A . 
J 4 HOH 54 1254 129 HOH HOH A . 
J 4 HOH 55 1255 200 HOH HOH A . 
J 4 HOH 56 1256 64  HOH HOH A . 
J 4 HOH 57 1257 284 HOH HOH A . 
J 4 HOH 58 1258 76  HOH HOH A . 
J 4 HOH 59 1259 249 HOH HOH A . 
J 4 HOH 60 1260 212 HOH HOH A . 
J 4 HOH 61 1261 247 HOH HOH A . 
J 4 HOH 62 1262 62  HOH HOH A . 
J 4 HOH 63 1263 173 HOH HOH A . 
J 4 HOH 64 1264 303 HOH HOH A . 
J 4 HOH 65 1265 305 HOH HOH A . 
J 4 HOH 66 1266 291 HOH HOH A . 
J 4 HOH 67 1267 160 HOH HOH A . 
J 4 HOH 68 1268 169 HOH HOH A . 
J 4 HOH 69 1269 217 HOH HOH A . 
J 4 HOH 70 1270 146 HOH HOH A . 
K 4 HOH 1  1801 4   HOH HOH E . 
K 4 HOH 2  1802 103 HOH HOH E . 
K 4 HOH 3  1803 81  HOH HOH E . 
K 4 HOH 4  1804 126 HOH HOH E . 
K 4 HOH 5  1805 139 HOH HOH E . 
K 4 HOH 6  1806 161 HOH HOH E . 
K 4 HOH 7  1807 93  HOH HOH E . 
K 4 HOH 8  1808 293 HOH HOH E . 
L 4 HOH 1  1301 262 HOH HOH B . 
L 4 HOH 2  1302 7   HOH HOH B . 
L 4 HOH 3  1303 15  HOH HOH B . 
L 4 HOH 4  1304 65  HOH HOH B . 
L 4 HOH 5  1305 106 HOH HOH B . 
L 4 HOH 6  1306 177 HOH HOH B . 
L 4 HOH 7  1307 119 HOH HOH B . 
L 4 HOH 8  1308 285 HOH HOH B . 
L 4 HOH 9  1309 3   HOH HOH B . 
L 4 HOH 10 1310 281 HOH HOH B . 
L 4 HOH 11 1311 105 HOH HOH B . 
L 4 HOH 12 1312 125 HOH HOH B . 
L 4 HOH 13 1313 77  HOH HOH B . 
L 4 HOH 14 1314 22  HOH HOH B . 
L 4 HOH 15 1315 117 HOH HOH B . 
L 4 HOH 16 1316 197 HOH HOH B . 
L 4 HOH 17 1317 16  HOH HOH B . 
L 4 HOH 18 1318 25  HOH HOH B . 
L 4 HOH 19 1319 271 HOH HOH B . 
L 4 HOH 20 1320 27  HOH HOH B . 
L 4 HOH 21 1321 203 HOH HOH B . 
L 4 HOH 22 1322 61  HOH HOH B . 
L 4 HOH 23 1323 41  HOH HOH B . 
L 4 HOH 24 1324 10  HOH HOH B . 
L 4 HOH 25 1325 282 HOH HOH B . 
L 4 HOH 26 1326 98  HOH HOH B . 
L 4 HOH 27 1327 100 HOH HOH B . 
L 4 HOH 28 1328 214 HOH HOH B . 
L 4 HOH 29 1329 74  HOH HOH B . 
L 4 HOH 30 1330 120 HOH HOH B . 
L 4 HOH 31 1331 199 HOH HOH B . 
L 4 HOH 32 1332 283 HOH HOH B . 
L 4 HOH 33 1333 36  HOH HOH B . 
L 4 HOH 34 1334 176 HOH HOH B . 
L 4 HOH 35 1335 87  HOH HOH B . 
L 4 HOH 36 1336 128 HOH HOH B . 
L 4 HOH 37 1337 162 HOH HOH B . 
L 4 HOH 38 1338 165 HOH HOH B . 
L 4 HOH 39 1339 124 HOH HOH B . 
L 4 HOH 40 1340 288 HOH HOH B . 
L 4 HOH 41 1341 163 HOH HOH B . 
L 4 HOH 42 1342 131 HOH HOH B . 
L 4 HOH 43 1343 111 HOH HOH B . 
L 4 HOH 44 1344 141 HOH HOH B . 
L 4 HOH 45 1345 258 HOH HOH B . 
L 4 HOH 46 1346 53  HOH HOH B . 
L 4 HOH 47 1347 118 HOH HOH B . 
L 4 HOH 48 1348 307 HOH HOH B . 
L 4 HOH 49 1349 57  HOH HOH B . 
L 4 HOH 50 1350 298 HOH HOH B . 
L 4 HOH 51 1351 233 HOH HOH B . 
L 4 HOH 52 1352 172 HOH HOH B . 
L 4 HOH 53 1353 85  HOH HOH B . 
L 4 HOH 54 1354 151 HOH HOH B . 
L 4 HOH 55 1355 294 HOH HOH B . 
L 4 HOH 56 1356 185 HOH HOH B . 
L 4 HOH 57 1357 207 HOH HOH B . 
L 4 HOH 58 1358 158 HOH HOH B . 
L 4 HOH 59 1359 72  HOH HOH B . 
L 4 HOH 60 1360 170 HOH HOH B . 
L 4 HOH 61 1361 206 HOH HOH B . 
L 4 HOH 62 1362 189 HOH HOH B . 
L 4 HOH 63 1363 248 HOH HOH B . 
L 4 HOH 64 1364 304 HOH HOH B . 
L 4 HOH 65 1365 227 HOH HOH B . 
L 4 HOH 66 1366 211 HOH HOH B . 
L 4 HOH 67 1367 292 HOH HOH B . 
L 4 HOH 68 1368 269 HOH HOH B . 
L 4 HOH 69 1369 280 HOH HOH B . 
L 4 HOH 70 1370 274 HOH HOH B . 
L 4 HOH 71 1371 68  HOH HOH B . 
L 4 HOH 72 1372 56  HOH HOH B . 
L 4 HOH 73 1373 202 HOH HOH B . 
L 4 HOH 74 1374 234 HOH HOH B . 
L 4 HOH 75 1375 310 HOH HOH B . 
M 4 HOH 1  1801 216 HOH HOH C . 
M 4 HOH 2  1802 133 HOH HOH C . 
M 4 HOH 3  1803 33  HOH HOH C . 
M 4 HOH 4  1804 12  HOH HOH C . 
M 4 HOH 5  1805 99  HOH HOH C . 
M 4 HOH 6  1806 51  HOH HOH C . 
M 4 HOH 7  1807 153 HOH HOH C . 
N 4 HOH 1  1201 147 HOH HOH D . 
N 4 HOH 2  1202 277 HOH HOH D . 
N 4 HOH 3  1203 69  HOH HOH D . 
N 4 HOH 4  1204 279 HOH HOH D . 
N 4 HOH 5  1205 2   HOH HOH D . 
N 4 HOH 6  1206 59  HOH HOH D . 
N 4 HOH 7  1207 17  HOH HOH D . 
N 4 HOH 8  1208 37  HOH HOH D . 
N 4 HOH 9  1209 8   HOH HOH D . 
N 4 HOH 10 1210 215 HOH HOH D . 
N 4 HOH 11 1211 84  HOH HOH D . 
N 4 HOH 12 1212 186 HOH HOH D . 
N 4 HOH 13 1213 256 HOH HOH D . 
N 4 HOH 14 1214 244 HOH HOH D . 
N 4 HOH 15 1215 144 HOH HOH D . 
N 4 HOH 16 1216 179 HOH HOH D . 
N 4 HOH 17 1217 155 HOH HOH D . 
N 4 HOH 18 1218 80  HOH HOH D . 
N 4 HOH 19 1219 48  HOH HOH D . 
N 4 HOH 20 1220 138 HOH HOH D . 
N 4 HOH 21 1221 195 HOH HOH D . 
N 4 HOH 22 1222 75  HOH HOH D . 
N 4 HOH 23 1223 193 HOH HOH D . 
N 4 HOH 24 1224 28  HOH HOH D . 
N 4 HOH 25 1225 220 HOH HOH D . 
N 4 HOH 26 1226 297 HOH HOH D . 
N 4 HOH 27 1227 82  HOH HOH D . 
N 4 HOH 28 1228 263 HOH HOH D . 
N 4 HOH 29 1229 31  HOH HOH D . 
N 4 HOH 30 1230 253 HOH HOH D . 
N 4 HOH 31 1231 232 HOH HOH D . 
N 4 HOH 32 1232 187 HOH HOH D . 
N 4 HOH 33 1233 122 HOH HOH D . 
N 4 HOH 34 1234 276 HOH HOH D . 
N 4 HOH 35 1235 70  HOH HOH D . 
N 4 HOH 36 1236 109 HOH HOH D . 
N 4 HOH 37 1237 159 HOH HOH D . 
N 4 HOH 38 1238 96  HOH HOH D . 
N 4 HOH 39 1239 300 HOH HOH D . 
N 4 HOH 40 1240 182 HOH HOH D . 
N 4 HOH 41 1241 251 HOH HOH D . 
N 4 HOH 42 1242 267 HOH HOH D . 
N 4 HOH 43 1243 154 HOH HOH D . 
N 4 HOH 44 1244 194 HOH HOH D . 
N 4 HOH 45 1245 40  HOH HOH D . 
N 4 HOH 46 1246 201 HOH HOH D . 
N 4 HOH 47 1247 112 HOH HOH D . 
N 4 HOH 48 1248 90  HOH HOH D . 
N 4 HOH 49 1249 209 HOH HOH D . 
N 4 HOH 50 1250 168 HOH HOH D . 
N 4 HOH 51 1251 268 HOH HOH D . 
N 4 HOH 52 1252 223 HOH HOH D . 
N 4 HOH 53 1253 259 HOH HOH D . 
N 4 HOH 54 1254 152 HOH HOH D . 
N 4 HOH 55 1255 135 HOH HOH D . 
N 4 HOH 56 1256 264 HOH HOH D . 
N 4 HOH 57 1257 289 HOH HOH D . 
N 4 HOH 58 1258 136 HOH HOH D . 
N 4 HOH 59 1259 255 HOH HOH D . 
N 4 HOH 60 1260 73  HOH HOH D . 
N 4 HOH 61 1261 243 HOH HOH D . 
N 4 HOH 62 1262 192 HOH HOH D . 
N 4 HOH 63 1263 295 HOH HOH D . 
N 4 HOH 64 1264 278 HOH HOH D . 
N 4 HOH 65 1265 275 HOH HOH D . 
N 4 HOH 66 1266 252 HOH HOH D . 
N 4 HOH 67 1267 110 HOH HOH D . 
N 4 HOH 68 1268 302 HOH HOH D . 
O 4 HOH 1  1801 94  HOH HOH F . 
O 4 HOH 2  1802 104 HOH HOH F . 
O 4 HOH 3  1803 270 HOH HOH F . 
O 4 HOH 4  1804 32  HOH HOH F . 
O 4 HOH 5  1805 218 HOH HOH F . 
O 4 HOH 6  1806 308 HOH HOH F . 
O 4 HOH 7  1807 309 HOH HOH F . 
O 4 HOH 8  1808 219 HOH HOH F . 
P 4 HOH 1  1201 156 HOH HOH G . 
P 4 HOH 2  1202 237 HOH HOH G . 
P 4 HOH 3  1203 210 HOH HOH G . 
P 4 HOH 4  1204 50  HOH HOH G . 
P 4 HOH 5  1205 241 HOH HOH G . 
P 4 HOH 6  1206 229 HOH HOH G . 
P 4 HOH 7  1207 14  HOH HOH G . 
P 4 HOH 8  1208 30  HOH HOH G . 
P 4 HOH 9  1209 11  HOH HOH G . 
P 4 HOH 10 1210 18  HOH HOH G . 
P 4 HOH 11 1211 148 HOH HOH G . 
P 4 HOH 12 1212 21  HOH HOH G . 
P 4 HOH 13 1213 19  HOH HOH G . 
P 4 HOH 14 1214 114 HOH HOH G . 
P 4 HOH 15 1215 63  HOH HOH G . 
P 4 HOH 16 1216 38  HOH HOH G . 
P 4 HOH 17 1217 261 HOH HOH G . 
P 4 HOH 18 1218 34  HOH HOH G . 
P 4 HOH 19 1219 225 HOH HOH G . 
P 4 HOH 20 1220 188 HOH HOH G . 
P 4 HOH 21 1221 24  HOH HOH G . 
P 4 HOH 22 1222 145 HOH HOH G . 
P 4 HOH 23 1223 83  HOH HOH G . 
P 4 HOH 24 1224 45  HOH HOH G . 
P 4 HOH 25 1225 35  HOH HOH G . 
P 4 HOH 26 1226 116 HOH HOH G . 
P 4 HOH 27 1227 301 HOH HOH G . 
P 4 HOH 28 1228 20  HOH HOH G . 
P 4 HOH 29 1229 44  HOH HOH G . 
P 4 HOH 30 1230 213 HOH HOH G . 
P 4 HOH 31 1231 150 HOH HOH G . 
P 4 HOH 32 1232 224 HOH HOH G . 
P 4 HOH 33 1233 149 HOH HOH G . 
P 4 HOH 34 1234 46  HOH HOH G . 
P 4 HOH 35 1235 254 HOH HOH G . 
P 4 HOH 36 1236 166 HOH HOH G . 
P 4 HOH 37 1237 55  HOH HOH G . 
P 4 HOH 38 1238 143 HOH HOH G . 
P 4 HOH 39 1239 239 HOH HOH G . 
P 4 HOH 40 1240 228 HOH HOH G . 
P 4 HOH 41 1241 242 HOH HOH G . 
P 4 HOH 42 1242 157 HOH HOH G . 
P 4 HOH 43 1243 86  HOH HOH G . 
P 4 HOH 44 1244 257 HOH HOH G . 
P 4 HOH 45 1245 222 HOH HOH G . 
P 4 HOH 46 1246 235 HOH HOH G . 
P 4 HOH 47 1247 245 HOH HOH G . 
P 4 HOH 48 1248 265 HOH HOH G . 
P 4 HOH 49 1249 240 HOH HOH G . 
P 4 HOH 50 1250 286 HOH HOH G . 
P 4 HOH 51 1251 183 HOH HOH G . 
P 4 HOH 52 1252 196 HOH HOH G . 
P 4 HOH 53 1253 89  HOH HOH G . 
P 4 HOH 54 1254 272 HOH HOH G . 
P 4 HOH 55 1255 78  HOH HOH G . 
P 4 HOH 56 1256 299 HOH HOH G . 
P 4 HOH 57 1257 230 HOH HOH G . 
P 4 HOH 58 1258 175 HOH HOH G . 
P 4 HOH 59 1259 101 HOH HOH G . 
P 4 HOH 60 1260 102 HOH HOH G . 
P 4 HOH 61 1261 250 HOH HOH G . 
P 4 HOH 62 1262 246 HOH HOH G . 
P 4 HOH 63 1263 236 HOH HOH G . 
P 4 HOH 64 1264 290 HOH HOH G . 
P 4 HOH 65 1265 260 HOH HOH G . 
P 4 HOH 66 1266 205 HOH HOH G . 
P 4 HOH 67 1267 226 HOH HOH G . 
P 4 HOH 68 1268 273 HOH HOH G . 
Q 4 HOH 1  1801 191 HOH HOH H . 
Q 4 HOH 2  1802 67  HOH HOH H . 
Q 4 HOH 3  1803 132 HOH HOH H . 
Q 4 HOH 4  1804 137 HOH HOH H . 
Q 4 HOH 5  1805 142 HOH HOH H . 
Q 4 HOH 6  1806 178 HOH HOH H . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 E LYS 1701 ? CG  ? B LYS 3  CG  
2  1 Y 1 E LYS 1701 ? CD  ? B LYS 3  CD  
3  1 Y 1 E LYS 1701 ? CE  ? B LYS 3  CE  
4  1 Y 1 E LYS 1701 ? NZ  ? B LYS 3  NZ  
5  1 Y 1 C ILE 1700 ? CG1 ? D ILE 2  CG1 
6  1 Y 1 C ILE 1700 ? CG2 ? D ILE 2  CG2 
7  1 Y 1 C ILE 1700 ? CD1 ? D ILE 2  CD1 
8  1 Y 1 C LYS 1701 ? CG  ? D LYS 3  CG  
9  1 Y 1 C LYS 1701 ? CD  ? D LYS 3  CD  
10 1 Y 1 C LYS 1701 ? CE  ? D LYS 3  CE  
11 1 Y 1 C LYS 1701 ? NZ  ? D LYS 3  NZ  
12 1 Y 1 F LYS 1701 ? CG  ? F LYS 3  CG  
13 1 Y 1 F LYS 1701 ? CD  ? F LYS 3  CD  
14 1 Y 1 F LYS 1701 ? CE  ? F LYS 3  CE  
15 1 Y 1 F LYS 1701 ? NZ  ? F LYS 3  NZ  
16 1 Y 1 G LYS 1086 ? CG  ? G LYS 8  CG  
17 1 Y 1 G LYS 1086 ? CD  ? G LYS 8  CD  
18 1 Y 1 G LYS 1086 ? CE  ? G LYS 8  CE  
19 1 Y 1 G LYS 1086 ? NZ  ? G LYS 8  NZ  
20 1 Y 1 G GLN 1120 ? CG  ? G GLN 42 CG  
21 1 Y 1 G GLN 1120 ? CD  ? G GLN 42 CD  
22 1 Y 1 G GLN 1120 ? OE1 ? G GLN 42 OE1 
23 1 Y 1 G GLN 1120 ? NE2 ? G GLN 42 NE2 
24 1 Y 1 H ARG 1706 ? CG  ? H ARG 8  CG  
25 1 Y 1 H ARG 1706 ? CD  ? H ARG 8  CD  
26 1 Y 1 H ARG 1706 ? NE  ? H ARG 8  NE  
27 1 Y 1 H ARG 1706 ? CZ  ? H ARG 8  CZ  
28 1 Y 1 H ARG 1706 ? NH1 ? H ARG 8  NH1 
29 1 Y 1 H ARG 1706 ? NH2 ? H ARG 8  NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    2 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot    ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS   ? ? ? .                    5 
# 
_cell.angle_alpha                  111.42 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.16 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  112.46 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8ZE8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     39.922 
_cell.length_a_esd                 ? 
_cell.length_b                     52.074 
_cell.length_b_esd                 ? 
_cell.length_c                     56.909 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8ZE8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8ZE8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.71 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.65 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M MES monohydrate, pH=6.0, 20 % w/v Polyethylene glycol 6,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 S 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-09-01 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8ZE8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.07 
_reflns.d_resolution_low                               32.49 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     23173 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.1 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.77 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.146 
_reflns.pdbx_Rpim_I_all                                0.080 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       75254 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.941 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.121 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.07 
_reflns_shell.d_res_low                                     2.12 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           4758 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1695 
_reflns_shell.percent_possible_obs                          95.4 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               2.8 
_reflns_shell.pdbx_chi_squared                              0.70 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     5.7 
_reflns_shell.pdbx_Rrim_I_all                               0.264 
_reflns_shell.pdbx_Rpim_I_all                               0.153 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.674 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.213 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8ZE8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.07 
_refine.ls_d_res_low                             32.40 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     23128 
_refine.ls_number_reflns_R_free                  1131 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.49 
_refine.ls_percent_reflns_R_free                 4.89 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1859 
_refine.ls_R_factor_R_free                       0.2260 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1838 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.97 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      3JV3 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.03 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.18 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.07 
_refine_hist.d_res_low                        32.40 
_refine_hist.number_atoms_solvent             310 
_refine_hist.number_atoms_total               2547 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2231 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         6 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.013 ? 2280 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.284 ? 3079 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 6.450 ? 291  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.066 ? 337  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.013 ? 398  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.07 2.16  . . 127 2716 96.00 . . . . 0.1988 . . . . . . . . . . . 0.2710 
'X-RAY DIFFRACTION' 2.16 2.28  . . 164 2721 96.00 . . . . 0.1968 . . . . . . . . . . . 0.2441 
'X-RAY DIFFRACTION' 2.28 2.42  . . 130 2697 97.00 . . . . 0.1837 . . . . . . . . . . . 0.2459 
'X-RAY DIFFRACTION' 2.42 2.61  . . 146 2776 97.00 . . . . 0.1946 . . . . . . . . . . . 0.2290 
'X-RAY DIFFRACTION' 2.61 2.87  . . 148 2740 98.00 . . . . 0.1865 . . . . . . . . . . . 0.2459 
'X-RAY DIFFRACTION' 2.87 3.29  . . 123 2773 98.00 . . . . 0.1830 . . . . . . . . . . . 0.2585 
'X-RAY DIFFRACTION' 3.29 4.14  . . 147 2787 99.00 . . . . 0.1625 . . . . . . . . . . . 0.1725 
'X-RAY DIFFRACTION' 4.14 32.40 . . 146 2787 99.00 . . . . 0.1890 . . . . . . . . . . . 0.2113 
# 
_struct.entry_id                     8ZE8 
_struct.title                        'Arf-GTPase activating protein Asap1 SH3 domain in complex with 440 Kd Ankyrin-B fragment' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8ZE8 
_struct_keywords.text            'complex, PROTEIN BINDING' 
_struct_keywords.pdbx_keywords   'PROTEIN BINDING' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 1 ? 
F N N 2 ? 
G N N 1 ? 
H N N 2 ? 
I N N 3 ? 
J N N 4 ? 
K N N 4 ? 
L N N 4 ? 
M N N 4 ? 
N N N 4 ? 
O N N 4 ? 
P N N 4 ? 
Q N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ASAP1_MOUSE Q9QWY8 ? 1 GKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1083 
2 UNP ANK2_HUMAN  Q01484 ? 2 GIKKPVRRKLKE                                                      1699 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8ZE8 A 5 ? 69 ? Q9QWY8 1083 ? 1147 ? 1083 1147 
2 2 8ZE8 E 1 ? 12 ? Q01484 1699 ? 1710 ? 1699 1710 
3 1 8ZE8 B 5 ? 69 ? Q9QWY8 1083 ? 1147 ? 1083 1147 
4 2 8ZE8 C 1 ? 12 ? Q01484 1699 ? 1710 ? 1699 1710 
5 1 8ZE8 D 5 ? 69 ? Q9QWY8 1083 ? 1147 ? 1083 1147 
6 2 8ZE8 F 1 ? 12 ? Q01484 1699 ? 1710 ? 1699 1710 
7 1 8ZE8 G 5 ? 69 ? Q9QWY8 1083 ? 1147 ? 1083 1147 
8 2 8ZE8 H 1 ? 12 ? Q01484 1699 ? 1710 ? 1699 1710 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8ZE8 GLY A 1 ? UNP Q9QWY8 ? ? 'expression tag' 1079 1  
1 8ZE8 PRO A 2 ? UNP Q9QWY8 ? ? 'expression tag' 1080 2  
1 8ZE8 GLY A 3 ? UNP Q9QWY8 ? ? 'expression tag' 1081 3  
1 8ZE8 SER A 4 ? UNP Q9QWY8 ? ? 'expression tag' 1082 4  
3 8ZE8 GLY B 1 ? UNP Q9QWY8 ? ? 'expression tag' 1079 5  
3 8ZE8 PRO B 2 ? UNP Q9QWY8 ? ? 'expression tag' 1080 6  
3 8ZE8 GLY B 3 ? UNP Q9QWY8 ? ? 'expression tag' 1081 7  
3 8ZE8 SER B 4 ? UNP Q9QWY8 ? ? 'expression tag' 1082 8  
5 8ZE8 GLY D 1 ? UNP Q9QWY8 ? ? 'expression tag' 1079 9  
5 8ZE8 PRO D 2 ? UNP Q9QWY8 ? ? 'expression tag' 1080 10 
5 8ZE8 GLY D 3 ? UNP Q9QWY8 ? ? 'expression tag' 1081 11 
5 8ZE8 SER D 4 ? UNP Q9QWY8 ? ? 'expression tag' 1082 12 
7 8ZE8 GLY G 1 ? UNP Q9QWY8 ? ? 'expression tag' 1079 13 
7 8ZE8 PRO G 2 ? UNP Q9QWY8 ? ? 'expression tag' 1080 14 
7 8ZE8 GLY G 3 ? UNP Q9QWY8 ? ? 'expression tag' 1081 15 
7 8ZE8 SER G 4 ? UNP Q9QWY8 ? ? 'expression tag' 1082 16 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
3 author_and_software_defined_assembly PISA dimeric 2 
4 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 820  ? 
1 MORE         -1   ? 
1 'SSA (A^2)'  4330 ? 
2 'ABSA (A^2)' 940  ? 
2 MORE         -1   ? 
2 'SSA (A^2)'  4520 ? 
3 'ABSA (A^2)' 880  ? 
3 MORE         -2   ? 
3 'SSA (A^2)'  4290 ? 
4 'ABSA (A^2)' 890  ? 
4 MORE         -1   ? 
4 'SSA (A^2)'  4260 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,J,K   
2 1 C,D,I,L,M 
3 1 E,F,N,O   
4 1 G,H,P,Q   
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'isothermal titration calorimetry' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
AA3 ? 5 ? 
AA4 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 52 ? PRO A 60 ? GLN A 1130 PRO A 1138 
AA1 2 TRP A 44 ? ILE A 49 ? TRP A 1122 ILE A 1127 
AA1 3 VAL A 33 ? ASP A 41 ? VAL A 1111 ASP A 1119 
AA1 4 ARG A 11 ? THR A 14 ? ARG A 1089 THR A 1092 
AA1 5 VAL A 64 ? SER A 68 ? VAL A 1142 SER A 1146 
AA2 1 GLN C 52 ? PRO C 60 ? GLN B 1130 PRO B 1138 
AA2 2 TRP C 44 ? ILE C 49 ? TRP B 1122 ILE B 1127 
AA2 3 VAL C 33 ? ASP C 41 ? VAL B 1111 ASP B 1119 
AA2 4 ARG C 11 ? THR C 14 ? ARG B 1089 THR B 1092 
AA2 5 VAL C 64 ? ILE C 66 ? VAL B 1142 ILE B 1144 
AA3 1 GLN E 52 ? PRO E 60 ? GLN D 1130 PRO D 1138 
AA3 2 TRP E 44 ? ILE E 49 ? TRP D 1122 ILE D 1127 
AA3 3 VAL E 33 ? ASP E 41 ? VAL D 1111 ASP D 1119 
AA3 4 ARG E 11 ? THR E 14 ? ARG D 1089 THR D 1092 
AA3 5 VAL E 64 ? ILE E 66 ? VAL D 1142 ILE D 1144 
AA4 1 GLN G 52 ? PRO G 60 ? GLN G 1130 PRO G 1138 
AA4 2 TRP G 44 ? ILE G 49 ? TRP G 1122 ILE G 1127 
AA4 3 VAL G 33 ? GLU G 39 ? VAL G 1111 GLU G 1117 
AA4 4 ARG G 11 ? THR G 14 ? ARG G 1089 THR G 1092 
AA4 5 VAL G 64 ? SER G 68 ? VAL G 1142 SER G 1146 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O PHE A 59 ? O PHE A 1137 N TRP A 45 ? N TRP A 1123 
AA1 2 3 O HIS A 48 ? O HIS A 1126 N ILE A 35 ? N ILE A 1113 
AA1 3 4 O ILE A 34 ? O ILE A 1112 N VAL A 12 ? N VAL A 1090 
AA1 4 5 N LYS A 13 ? N LYS A 1091 O HIS A 65 ? O HIS A 1143 
AA2 1 2 O PHE C 59 ? O PHE B 1137 N TRP C 45 ? N TRP B 1123 
AA2 2 3 O HIS C 48 ? O HIS B 1126 N ILE C 35 ? N ILE B 1113 
AA2 3 4 O ILE C 34 ? O ILE B 1112 N VAL C 12 ? N VAL B 1090 
AA2 4 5 N LYS C 13 ? N LYS B 1091 O HIS C 65 ? O HIS B 1143 
AA3 1 2 O PHE E 59 ? O PHE D 1137 N TRP E 45 ? N TRP D 1123 
AA3 2 3 O HIS E 48 ? O HIS D 1126 N ILE E 35 ? N ILE D 1113 
AA3 3 4 O ILE E 34 ? O ILE D 1112 N VAL E 12 ? N VAL D 1090 
AA3 4 5 N LYS E 13 ? N LYS D 1091 O HIS E 65 ? O HIS D 1143 
AA4 1 2 O GLY G 57 ? O GLY G 1135 N GLY G 47 ? N GLY G 1125 
AA4 2 3 O HIS G 48 ? O HIS G 1126 N ILE G 35 ? N ILE G 1113 
AA4 3 4 O ILE G 34 ? O ILE G 1112 N VAL G 12 ? N VAL G 1090 
AA4 4 5 N LYS G 13 ? N LYS G 1091 O HIS G 65 ? O HIS G 1143 
# 
_pdbx_entry_details.entry_id                   8ZE8 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 HH12 B ARG 1089 ? ? OE2 B GLU 1128 ? ? 1.34 
2  1 O    B HOH 1319 ? ? O   B HOH 1355 ? ? 1.81 
3  1 O    A HOH 1252 ? ? O   A HOH 1268 ? ? 1.88 
4  1 O    G HOH 1265 ? ? O   G HOH 1267 ? ? 1.89 
5  1 O    G HOH 1246 ? ? O   G HOH 1263 ? ? 1.91 
6  1 O    A HOH 1245 ? ? O   A HOH 1260 ? ? 1.94 
7  1 O    D HOH 1216 ? ? O   D HOH 1262 ? ? 1.95 
8  1 O    D HOH 1257 ? ? O   D HOH 1265 ? ? 1.96 
9  1 O    B HOH 1334 ? ? O   B HOH 1350 ? ? 1.96 
10 1 O    G HOH 1205 ? ? O   G HOH 1219 ? ? 1.97 
11 1 O    A HOH 1206 ? ? O   A HOH 1238 ? ? 1.98 
12 1 O    B HOH 1354 ? ? O   B HOH 1368 ? ? 2.04 
13 1 O    G HOH 1247 ? ? O   G HOH 1248 ? ? 2.13 
14 1 O    G HOH 1230 ? ? O   G HOH 1257 ? ? 2.13 
15 1 NH1  B ARG 1089 ? ? OE2 B GLU 1128 ? ? 2.15 
16 1 O2   B GOL 1201 ? ? O   B HOH 1301 ? ? 2.17 
17 1 O    G HOH 1266 ? ? O   G HOH 1267 ? ? 2.17 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     1243 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    D 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     1249 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_655 
_pdbx_validate_symm_contact.dist              2.10 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CA B GLN 1120 ? ? CB B GLN 1120 ? ? CG  B GLN 1120 ? ? 96.73 113.40 -16.67 2.20 N 
2 1 CB B LEU 1145 ? ? CG B LEU 1145 ? ? CD1 B LEU 1145 ? ? 99.00 111.00 -12.00 1.70 N 
3 1 CB D LYS 1086 ? ? CG D LYS 1086 ? ? CD  D LYS 1086 ? ? 93.60 111.60 -18.00 2.60 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER B 1146 ? ? 32.43   61.92   
2 1 ASP D 1119 ? ? -160.32 -166.97 
3 1 LEU D 1145 ? ? -120.68 -53.94  
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      B 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1375 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   . 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          6.58 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 1079 ? A GLY 1  
2  1 Y 1 A PRO 1080 ? A PRO 2  
3  1 Y 1 A GLY 1081 ? A GLY 3  
4  1 Y 1 A SER 1082 ? A SER 4  
5  1 Y 1 A GLY 1083 ? A GLY 5  
6  1 Y 1 A LYS 1084 ? A LYS 6  
7  1 Y 1 A ASN 1085 ? A ASN 7  
8  1 Y 1 E GLY 1699 ? B GLY 1  
9  1 Y 1 E LYS 1707 ? B LYS 9  
10 1 Y 1 E LEU 1708 ? B LEU 10 
11 1 Y 1 E LYS 1709 ? B LYS 11 
12 1 Y 1 E GLU 1710 ? B GLU 12 
13 1 Y 1 B GLY 1079 ? C GLY 1  
14 1 Y 1 B PRO 1080 ? C PRO 2  
15 1 Y 1 B GLY 1081 ? C GLY 3  
16 1 Y 1 B SER 1082 ? C SER 4  
17 1 Y 1 B GLY 1083 ? C GLY 5  
18 1 Y 1 B LYS 1084 ? C LYS 6  
19 1 Y 1 B ASN 1085 ? C ASN 7  
20 1 Y 1 C GLY 1699 ? D GLY 1  
21 1 Y 1 C LYS 1707 ? D LYS 9  
22 1 Y 1 C LEU 1708 ? D LEU 10 
23 1 Y 1 C LYS 1709 ? D LYS 11 
24 1 Y 1 C GLU 1710 ? D GLU 12 
25 1 Y 1 D GLY 1079 ? E GLY 1  
26 1 Y 1 D PRO 1080 ? E PRO 2  
27 1 Y 1 D GLY 1081 ? E GLY 3  
28 1 Y 1 D SER 1082 ? E SER 4  
29 1 Y 1 D GLY 1083 ? E GLY 5  
30 1 Y 1 D LYS 1084 ? E LYS 6  
31 1 Y 1 D ASN 1085 ? E ASN 7  
32 1 Y 1 D ASP 1147 ? E ASP 69 
33 1 Y 1 F GLY 1699 ? F GLY 1  
34 1 Y 1 F LYS 1707 ? F LYS 9  
35 1 Y 1 F LEU 1708 ? F LEU 10 
36 1 Y 1 F LYS 1709 ? F LYS 11 
37 1 Y 1 F GLU 1710 ? F GLU 12 
38 1 Y 1 G GLY 1079 ? G GLY 1  
39 1 Y 1 G PRO 1080 ? G PRO 2  
40 1 Y 1 G GLY 1081 ? G GLY 3  
41 1 Y 1 G SER 1082 ? G SER 4  
42 1 Y 1 G GLY 1083 ? G GLY 5  
43 1 Y 1 G LYS 1084 ? G LYS 6  
44 1 Y 1 G ASN 1085 ? G ASN 7  
45 1 Y 1 G ASP 1147 ? G ASP 69 
46 1 Y 1 H GLY 1699 ? H GLY 1  
47 1 Y 1 H LYS 1707 ? H LYS 9  
48 1 Y 1 H LEU 1708 ? H LEU 10 
49 1 Y 1 H LYS 1709 ? H LYS 11 
50 1 Y 1 H GLU 1710 ? H GLU 12 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
GOL C1   C N N 137 
GOL O1   O N N 138 
GOL C2   C N N 139 
GOL O2   O N N 140 
GOL C3   C N N 141 
GOL O3   O N N 142 
GOL H11  H N N 143 
GOL H12  H N N 144 
GOL HO1  H N N 145 
GOL H2   H N N 146 
GOL HO2  H N N 147 
GOL H31  H N N 148 
GOL H32  H N N 149 
GOL HO3  H N N 150 
HIS N    N N N 151 
HIS CA   C N S 152 
HIS C    C N N 153 
HIS O    O N N 154 
HIS CB   C N N 155 
HIS CG   C Y N 156 
HIS ND1  N Y N 157 
HIS CD2  C Y N 158 
HIS CE1  C Y N 159 
HIS NE2  N Y N 160 
HIS OXT  O N N 161 
HIS H    H N N 162 
HIS H2   H N N 163 
HIS HA   H N N 164 
HIS HB2  H N N 165 
HIS HB3  H N N 166 
HIS HD1  H N N 167 
HIS HD2  H N N 168 
HIS HE1  H N N 169 
HIS HE2  H N N 170 
HIS HXT  H N N 171 
HOH O    O N N 172 
HOH H1   H N N 173 
HOH H2   H N N 174 
ILE N    N N N 175 
ILE CA   C N S 176 
ILE C    C N N 177 
ILE O    O N N 178 
ILE CB   C N S 179 
ILE CG1  C N N 180 
ILE CG2  C N N 181 
ILE CD1  C N N 182 
ILE OXT  O N N 183 
ILE H    H N N 184 
ILE H2   H N N 185 
ILE HA   H N N 186 
ILE HB   H N N 187 
ILE HG12 H N N 188 
ILE HG13 H N N 189 
ILE HG21 H N N 190 
ILE HG22 H N N 191 
ILE HG23 H N N 192 
ILE HD11 H N N 193 
ILE HD12 H N N 194 
ILE HD13 H N N 195 
ILE HXT  H N N 196 
LEU N    N N N 197 
LEU CA   C N S 198 
LEU C    C N N 199 
LEU O    O N N 200 
LEU CB   C N N 201 
LEU CG   C N N 202 
LEU CD1  C N N 203 
LEU CD2  C N N 204 
LEU OXT  O N N 205 
LEU H    H N N 206 
LEU H2   H N N 207 
LEU HA   H N N 208 
LEU HB2  H N N 209 
LEU HB3  H N N 210 
LEU HG   H N N 211 
LEU HD11 H N N 212 
LEU HD12 H N N 213 
LEU HD13 H N N 214 
LEU HD21 H N N 215 
LEU HD22 H N N 216 
LEU HD23 H N N 217 
LEU HXT  H N N 218 
LYS N    N N N 219 
LYS CA   C N S 220 
LYS C    C N N 221 
LYS O    O N N 222 
LYS CB   C N N 223 
LYS CG   C N N 224 
LYS CD   C N N 225 
LYS CE   C N N 226 
LYS NZ   N N N 227 
LYS OXT  O N N 228 
LYS H    H N N 229 
LYS H2   H N N 230 
LYS HA   H N N 231 
LYS HB2  H N N 232 
LYS HB3  H N N 233 
LYS HG2  H N N 234 
LYS HG3  H N N 235 
LYS HD2  H N N 236 
LYS HD3  H N N 237 
LYS HE2  H N N 238 
LYS HE3  H N N 239 
LYS HZ1  H N N 240 
LYS HZ2  H N N 241 
LYS HZ3  H N N 242 
LYS HXT  H N N 243 
PHE N    N N N 244 
PHE CA   C N S 245 
PHE C    C N N 246 
PHE O    O N N 247 
PHE CB   C N N 248 
PHE CG   C Y N 249 
PHE CD1  C Y N 250 
PHE CD2  C Y N 251 
PHE CE1  C Y N 252 
PHE CE2  C Y N 253 
PHE CZ   C Y N 254 
PHE OXT  O N N 255 
PHE H    H N N 256 
PHE H2   H N N 257 
PHE HA   H N N 258 
PHE HB2  H N N 259 
PHE HB3  H N N 260 
PHE HD1  H N N 261 
PHE HD2  H N N 262 
PHE HE1  H N N 263 
PHE HE2  H N N 264 
PHE HZ   H N N 265 
PHE HXT  H N N 266 
PRO N    N N N 267 
PRO CA   C N S 268 
PRO C    C N N 269 
PRO O    O N N 270 
PRO CB   C N N 271 
PRO CG   C N N 272 
PRO CD   C N N 273 
PRO OXT  O N N 274 
PRO H    H N N 275 
PRO HA   H N N 276 
PRO HB2  H N N 277 
PRO HB3  H N N 278 
PRO HG2  H N N 279 
PRO HG3  H N N 280 
PRO HD2  H N N 281 
PRO HD3  H N N 282 
PRO HXT  H N N 283 
SER N    N N N 284 
SER CA   C N S 285 
SER C    C N N 286 
SER O    O N N 287 
SER CB   C N N 288 
SER OG   O N N 289 
SER OXT  O N N 290 
SER H    H N N 291 
SER H2   H N N 292 
SER HA   H N N 293 
SER HB2  H N N 294 
SER HB3  H N N 295 
SER HG   H N N 296 
SER HXT  H N N 297 
THR N    N N N 298 
THR CA   C N S 299 
THR C    C N N 300 
THR O    O N N 301 
THR CB   C N R 302 
THR OG1  O N N 303 
THR CG2  C N N 304 
THR OXT  O N N 305 
THR H    H N N 306 
THR H2   H N N 307 
THR HA   H N N 308 
THR HB   H N N 309 
THR HG1  H N N 310 
THR HG21 H N N 311 
THR HG22 H N N 312 
THR HG23 H N N 313 
THR HXT  H N N 314 
TRP N    N N N 315 
TRP CA   C N S 316 
TRP C    C N N 317 
TRP O    O N N 318 
TRP CB   C N N 319 
TRP CG   C Y N 320 
TRP CD1  C Y N 321 
TRP CD2  C Y N 322 
TRP NE1  N Y N 323 
TRP CE2  C Y N 324 
TRP CE3  C Y N 325 
TRP CZ2  C Y N 326 
TRP CZ3  C Y N 327 
TRP CH2  C Y N 328 
TRP OXT  O N N 329 
TRP H    H N N 330 
TRP H2   H N N 331 
TRP HA   H N N 332 
TRP HB2  H N N 333 
TRP HB3  H N N 334 
TRP HD1  H N N 335 
TRP HE1  H N N 336 
TRP HE3  H N N 337 
TRP HZ2  H N N 338 
TRP HZ3  H N N 339 
TRP HH2  H N N 340 
TRP HXT  H N N 341 
TYR N    N N N 342 
TYR CA   C N S 343 
TYR C    C N N 344 
TYR O    O N N 345 
TYR CB   C N N 346 
TYR CG   C Y N 347 
TYR CD1  C Y N 348 
TYR CD2  C Y N 349 
TYR CE1  C Y N 350 
TYR CE2  C Y N 351 
TYR CZ   C Y N 352 
TYR OH   O N N 353 
TYR OXT  O N N 354 
TYR H    H N N 355 
TYR H2   H N N 356 
TYR HA   H N N 357 
TYR HB2  H N N 358 
TYR HB3  H N N 359 
TYR HD1  H N N 360 
TYR HD2  H N N 361 
TYR HE1  H N N 362 
TYR HE2  H N N 363 
TYR HH   H N N 364 
TYR HXT  H N N 365 
VAL N    N N N 366 
VAL CA   C N S 367 
VAL C    C N N 368 
VAL O    O N N 369 
VAL CB   C N N 370 
VAL CG1  C N N 371 
VAL CG2  C N N 372 
VAL OXT  O N N 373 
VAL H    H N N 374 
VAL H2   H N N 375 
VAL HA   H N N 376 
VAL HB   H N N 377 
VAL HG11 H N N 378 
VAL HG12 H N N 379 
VAL HG13 H N N 380 
VAL HG21 H N N 381 
VAL HG22 H N N 382 
VAL HG23 H N N 383 
VAL HXT  H N N 384 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GOL C1  O1   sing N N 129 
GOL C1  C2   sing N N 130 
GOL C1  H11  sing N N 131 
GOL C1  H12  sing N N 132 
GOL O1  HO1  sing N N 133 
GOL C2  O2   sing N N 134 
GOL C2  C3   sing N N 135 
GOL C2  H2   sing N N 136 
GOL O2  HO2  sing N N 137 
GOL C3  O3   sing N N 138 
GOL C3  H31  sing N N 139 
GOL C3  H32  sing N N 140 
GOL O3  HO3  sing N N 141 
HIS N   CA   sing N N 142 
HIS N   H    sing N N 143 
HIS N   H2   sing N N 144 
HIS CA  C    sing N N 145 
HIS CA  CB   sing N N 146 
HIS CA  HA   sing N N 147 
HIS C   O    doub N N 148 
HIS C   OXT  sing N N 149 
HIS CB  CG   sing N N 150 
HIS CB  HB2  sing N N 151 
HIS CB  HB3  sing N N 152 
HIS CG  ND1  sing Y N 153 
HIS CG  CD2  doub Y N 154 
HIS ND1 CE1  doub Y N 155 
HIS ND1 HD1  sing N N 156 
HIS CD2 NE2  sing Y N 157 
HIS CD2 HD2  sing N N 158 
HIS CE1 NE2  sing Y N 159 
HIS CE1 HE1  sing N N 160 
HIS NE2 HE2  sing N N 161 
HIS OXT HXT  sing N N 162 
HOH O   H1   sing N N 163 
HOH O   H2   sing N N 164 
ILE N   CA   sing N N 165 
ILE N   H    sing N N 166 
ILE N   H2   sing N N 167 
ILE CA  C    sing N N 168 
ILE CA  CB   sing N N 169 
ILE CA  HA   sing N N 170 
ILE C   O    doub N N 171 
ILE C   OXT  sing N N 172 
ILE CB  CG1  sing N N 173 
ILE CB  CG2  sing N N 174 
ILE CB  HB   sing N N 175 
ILE CG1 CD1  sing N N 176 
ILE CG1 HG12 sing N N 177 
ILE CG1 HG13 sing N N 178 
ILE CG2 HG21 sing N N 179 
ILE CG2 HG22 sing N N 180 
ILE CG2 HG23 sing N N 181 
ILE CD1 HD11 sing N N 182 
ILE CD1 HD12 sing N N 183 
ILE CD1 HD13 sing N N 184 
ILE OXT HXT  sing N N 185 
LEU N   CA   sing N N 186 
LEU N   H    sing N N 187 
LEU N   H2   sing N N 188 
LEU CA  C    sing N N 189 
LEU CA  CB   sing N N 190 
LEU CA  HA   sing N N 191 
LEU C   O    doub N N 192 
LEU C   OXT  sing N N 193 
LEU CB  CG   sing N N 194 
LEU CB  HB2  sing N N 195 
LEU CB  HB3  sing N N 196 
LEU CG  CD1  sing N N 197 
LEU CG  CD2  sing N N 198 
LEU CG  HG   sing N N 199 
LEU CD1 HD11 sing N N 200 
LEU CD1 HD12 sing N N 201 
LEU CD1 HD13 sing N N 202 
LEU CD2 HD21 sing N N 203 
LEU CD2 HD22 sing N N 204 
LEU CD2 HD23 sing N N 205 
LEU OXT HXT  sing N N 206 
LYS N   CA   sing N N 207 
LYS N   H    sing N N 208 
LYS N   H2   sing N N 209 
LYS CA  C    sing N N 210 
LYS CA  CB   sing N N 211 
LYS CA  HA   sing N N 212 
LYS C   O    doub N N 213 
LYS C   OXT  sing N N 214 
LYS CB  CG   sing N N 215 
LYS CB  HB2  sing N N 216 
LYS CB  HB3  sing N N 217 
LYS CG  CD   sing N N 218 
LYS CG  HG2  sing N N 219 
LYS CG  HG3  sing N N 220 
LYS CD  CE   sing N N 221 
LYS CD  HD2  sing N N 222 
LYS CD  HD3  sing N N 223 
LYS CE  NZ   sing N N 224 
LYS CE  HE2  sing N N 225 
LYS CE  HE3  sing N N 226 
LYS NZ  HZ1  sing N N 227 
LYS NZ  HZ2  sing N N 228 
LYS NZ  HZ3  sing N N 229 
LYS OXT HXT  sing N N 230 
PHE N   CA   sing N N 231 
PHE N   H    sing N N 232 
PHE N   H2   sing N N 233 
PHE CA  C    sing N N 234 
PHE CA  CB   sing N N 235 
PHE CA  HA   sing N N 236 
PHE C   O    doub N N 237 
PHE C   OXT  sing N N 238 
PHE CB  CG   sing N N 239 
PHE CB  HB2  sing N N 240 
PHE CB  HB3  sing N N 241 
PHE CG  CD1  doub Y N 242 
PHE CG  CD2  sing Y N 243 
PHE CD1 CE1  sing Y N 244 
PHE CD1 HD1  sing N N 245 
PHE CD2 CE2  doub Y N 246 
PHE CD2 HD2  sing N N 247 
PHE CE1 CZ   doub Y N 248 
PHE CE1 HE1  sing N N 249 
PHE CE2 CZ   sing Y N 250 
PHE CE2 HE2  sing N N 251 
PHE CZ  HZ   sing N N 252 
PHE OXT HXT  sing N N 253 
PRO N   CA   sing N N 254 
PRO N   CD   sing N N 255 
PRO N   H    sing N N 256 
PRO CA  C    sing N N 257 
PRO CA  CB   sing N N 258 
PRO CA  HA   sing N N 259 
PRO C   O    doub N N 260 
PRO C   OXT  sing N N 261 
PRO CB  CG   sing N N 262 
PRO CB  HB2  sing N N 263 
PRO CB  HB3  sing N N 264 
PRO CG  CD   sing N N 265 
PRO CG  HG2  sing N N 266 
PRO CG  HG3  sing N N 267 
PRO CD  HD2  sing N N 268 
PRO CD  HD3  sing N N 269 
PRO OXT HXT  sing N N 270 
SER N   CA   sing N N 271 
SER N   H    sing N N 272 
SER N   H2   sing N N 273 
SER CA  C    sing N N 274 
SER CA  CB   sing N N 275 
SER CA  HA   sing N N 276 
SER C   O    doub N N 277 
SER C   OXT  sing N N 278 
SER CB  OG   sing N N 279 
SER CB  HB2  sing N N 280 
SER CB  HB3  sing N N 281 
SER OG  HG   sing N N 282 
SER OXT HXT  sing N N 283 
THR N   CA   sing N N 284 
THR N   H    sing N N 285 
THR N   H2   sing N N 286 
THR CA  C    sing N N 287 
THR CA  CB   sing N N 288 
THR CA  HA   sing N N 289 
THR C   O    doub N N 290 
THR C   OXT  sing N N 291 
THR CB  OG1  sing N N 292 
THR CB  CG2  sing N N 293 
THR CB  HB   sing N N 294 
THR OG1 HG1  sing N N 295 
THR CG2 HG21 sing N N 296 
THR CG2 HG22 sing N N 297 
THR CG2 HG23 sing N N 298 
THR OXT HXT  sing N N 299 
TRP N   CA   sing N N 300 
TRP N   H    sing N N 301 
TRP N   H2   sing N N 302 
TRP CA  C    sing N N 303 
TRP CA  CB   sing N N 304 
TRP CA  HA   sing N N 305 
TRP C   O    doub N N 306 
TRP C   OXT  sing N N 307 
TRP CB  CG   sing N N 308 
TRP CB  HB2  sing N N 309 
TRP CB  HB3  sing N N 310 
TRP CG  CD1  doub Y N 311 
TRP CG  CD2  sing Y N 312 
TRP CD1 NE1  sing Y N 313 
TRP CD1 HD1  sing N N 314 
TRP CD2 CE2  doub Y N 315 
TRP CD2 CE3  sing Y N 316 
TRP NE1 CE2  sing Y N 317 
TRP NE1 HE1  sing N N 318 
TRP CE2 CZ2  sing Y N 319 
TRP CE3 CZ3  doub Y N 320 
TRP CE3 HE3  sing N N 321 
TRP CZ2 CH2  doub Y N 322 
TRP CZ2 HZ2  sing N N 323 
TRP CZ3 CH2  sing Y N 324 
TRP CZ3 HZ3  sing N N 325 
TRP CH2 HH2  sing N N 326 
TRP OXT HXT  sing N N 327 
TYR N   CA   sing N N 328 
TYR N   H    sing N N 329 
TYR N   H2   sing N N 330 
TYR CA  C    sing N N 331 
TYR CA  CB   sing N N 332 
TYR CA  HA   sing N N 333 
TYR C   O    doub N N 334 
TYR C   OXT  sing N N 335 
TYR CB  CG   sing N N 336 
TYR CB  HB2  sing N N 337 
TYR CB  HB3  sing N N 338 
TYR CG  CD1  doub Y N 339 
TYR CG  CD2  sing Y N 340 
TYR CD1 CE1  sing Y N 341 
TYR CD1 HD1  sing N N 342 
TYR CD2 CE2  doub Y N 343 
TYR CD2 HD2  sing N N 344 
TYR CE1 CZ   doub Y N 345 
TYR CE1 HE1  sing N N 346 
TYR CE2 CZ   sing Y N 347 
TYR CE2 HE2  sing N N 348 
TYR CZ  OH   sing N N 349 
TYR OH  HH   sing N N 350 
TYR OXT HXT  sing N N 351 
VAL N   CA   sing N N 352 
VAL N   H    sing N N 353 
VAL N   H2   sing N N 354 
VAL CA  C    sing N N 355 
VAL CA  CB   sing N N 356 
VAL CA  HA   sing N N 357 
VAL C   O    doub N N 358 
VAL C   OXT  sing N N 359 
VAL CB  CG1  sing N N 360 
VAL CB  CG2  sing N N 361 
VAL CB  HB   sing N N 362 
VAL CG1 HG11 sing N N 363 
VAL CG1 HG12 sing N N 364 
VAL CG1 HG13 sing N N 365 
VAL CG2 HG21 sing N N 366 
VAL CG2 HG22 sing N N 367 
VAL CG2 HG23 sing N N 368 
VAL OXT HXT  sing N N 369 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3JV3 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8ZE8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.025049 
_atom_sites.fract_transf_matrix[1][2]   0.010355 
_atom_sites.fract_transf_matrix[1][3]   0.004546 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.020780 
_atom_sites.fract_transf_matrix[2][3]   0.008970 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019139 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . LYS A 1 8  ? 16.336  16.234 -33.438 1.00 39.72 ? 1086 LYS A N    1 
ATOM   2    C CA   . LYS A 1 8  ? 15.802  17.173 -34.434 1.00 35.30 ? 1086 LYS A CA   1 
ATOM   3    C C    . LYS A 1 8  ? 15.091  18.364 -33.785 1.00 32.50 ? 1086 LYS A C    1 
ATOM   4    O O    . LYS A 1 8  ? 15.401  19.517 -34.093 1.00 31.93 ? 1086 LYS A O    1 
ATOM   5    C CB   . LYS A 1 8  ? 14.894  16.427 -35.383 1.00 40.68 ? 1086 LYS A CB   1 
ATOM   6    C CG   . LYS A 1 8  ? 14.333  17.271 -36.525 1.00 44.25 ? 1086 LYS A CG   1 
ATOM   7    C CD   . LYS A 1 8  ? 12.804  17.487 -36.435 1.00 50.15 ? 1086 LYS A CD   1 
ATOM   8    C CE   . LYS A 1 8  ? 12.003  16.191 -36.564 1.00 52.68 ? 1086 LYS A CE   1 
ATOM   9    N NZ   . LYS A 1 8  ? 10.638  16.292 -35.936 1.00 51.81 ? 1086 LYS A NZ   1 
ATOM   10   H HA   . LYS A 1 8  ? 16.531  17.555 -34.947 1.00 42.50 ? 1086 LYS A HA   1 
ATOM   11   H HB2  . LYS A 1 8  ? 15.395  15.696 -35.778 1.00 48.97 ? 1086 LYS A HB2  1 
ATOM   12   H HB3  . LYS A 1 8  ? 14.141  16.079 -34.880 1.00 48.97 ? 1086 LYS A HB3  1 
ATOM   13   H HG2  . LYS A 1 8  ? 14.758  18.143 -36.510 1.00 53.25 ? 1086 LYS A HG2  1 
ATOM   14   H HG3  . LYS A 1 8  ? 14.521  16.825 -37.367 1.00 53.25 ? 1086 LYS A HG3  1 
ATOM   15   H HD2  . LYS A 1 8  ? 12.592  17.883 -35.575 1.00 60.33 ? 1086 LYS A HD2  1 
ATOM   16   H HD3  . LYS A 1 8  ? 12.527  18.080 -37.151 1.00 60.33 ? 1086 LYS A HD3  1 
ATOM   17   H HE2  . LYS A 1 8  ? 11.887  15.982 -37.504 1.00 63.36 ? 1086 LYS A HE2  1 
ATOM   18   H HE3  . LYS A 1 8  ? 12.485  15.475 -36.121 1.00 63.36 ? 1086 LYS A HE3  1 
ATOM   19   H HZ1  . LYS A 1 8  ? 10.197  15.526 -36.043 1.00 62.31 ? 1086 LYS A HZ1  1 
ATOM   20   H HZ2  . LYS A 1 8  ? 10.715  16.462 -35.066 1.00 62.31 ? 1086 LYS A HZ2  1 
ATOM   21   H HZ3  . LYS A 1 8  ? 10.175  16.948 -36.319 1.00 62.31 ? 1086 LYS A HZ3  1 
ATOM   22   N N    . VAL A 1 9  ? 14.117  18.087 -32.925 1.00 24.75 ? 1087 VAL A N    1 
ATOM   23   C CA   . VAL A 1 9  ? 13.342  19.153 -32.297 1.00 21.60 ? 1087 VAL A CA   1 
ATOM   24   C C    . VAL A 1 9  ? 14.131  19.770 -31.141 1.00 13.24 ? 1087 VAL A C    1 
ATOM   25   O O    . VAL A 1 9  ? 14.589  19.074 -30.226 1.00 16.23 ? 1087 VAL A O    1 
ATOM   26   C CB   . VAL A 1 9  ? 11.987  18.620 -31.809 1.00 26.70 ? 1087 VAL A CB   1 
ATOM   27   C CG1  . VAL A 1 9  ? 11.296  19.710 -30.971 1.00 14.87 ? 1087 VAL A CG1  1 
ATOM   28   C CG2  . VAL A 1 9  ? 11.121  18.195 -32.989 1.00 26.02 ? 1087 VAL A CG2  1 
ATOM   29   H H    . VAL A 1 9  ? 13.885  17.293 -32.690 1.00 29.84 ? 1087 VAL A H    1 
ATOM   30   H HA   . VAL A 1 9  ? 13.190  19.848 -32.956 1.00 26.06 ? 1087 VAL A HA   1 
ATOM   31   H HB   . VAL A 1 9  ? 12.117  17.834 -31.255 1.00 32.19 ? 1087 VAL A HB   1 
ATOM   32   H HG11 . VAL A 1 9  ? 10.355  19.493 -30.885 1.00 17.99 ? 1087 VAL A HG11 1 
ATOM   33   H HG12 . VAL A 1 9  ? 11.710  19.745 -30.095 1.00 17.99 ? 1087 VAL A HG12 1 
ATOM   34   H HG13 . VAL A 1 9  ? 11.399  20.565 -31.419 1.00 17.99 ? 1087 VAL A HG13 1 
ATOM   35   H HG21 . VAL A 1 9  ? 10.274  17.861 -32.655 1.00 31.37 ? 1087 VAL A HG21 1 
ATOM   36   H HG22 . VAL A 1 9  ? 10.970  18.963 -33.562 1.00 31.37 ? 1087 VAL A HG22 1 
ATOM   37   H HG23 . VAL A 1 9  ? 11.580  17.499 -33.483 1.00 31.37 ? 1087 VAL A HG23 1 
ATOM   38   N N    . ARG A 1 10 ? 14.209  21.087 -31.119 1.00 13.99 ? 1088 ARG A N    1 
ATOM   39   C CA   . ARG A 1 10 ? 14.958  21.768 -30.070 1.00 14.63 ? 1088 ARG A CA   1 
ATOM   40   C C    . ARG A 1 10 ? 14.116  22.708 -29.233 1.00 12.60 ? 1088 ARG A C    1 
ATOM   41   O O    . ARG A 1 10 ? 14.354  22.815 -28.017 1.00 10.38 ? 1088 ARG A O    1 
ATOM   42   C CB   . ARG A 1 10 ? 16.157  22.544 -30.654 1.00 13.56 ? 1088 ARG A CB   1 
ATOM   43   C CG   . ARG A 1 10 ? 17.013  23.259 -29.590 1.00 14.80 ? 1088 ARG A CG   1 
ATOM   44   C CD   . ARG A 1 10 ? 18.266  23.941 -30.229 1.00 10.68 ? 1088 ARG A CD   1 
ATOM   45   N NE   . ARG A 1 10 ? 17.883  25.031 -31.119 1.00 10.19 ? 1088 ARG A NE   1 
ATOM   46   C CZ   . ARG A 1 10 ? 17.757  26.291 -30.743 1.00 10.11 ? 1088 ARG A CZ   1 
ATOM   47   N NH1  . ARG A 1 10 ? 18.037  26.665 -29.513 1.00 9.39  ? 1088 ARG A NH1  1 
ATOM   48   N NH2  . ARG A 1 10 ? 17.308  27.193 -31.616 1.00 10.75 ? 1088 ARG A NH2  1 
ATOM   49   H H    . ARG A 1 10 ? 13.840  21.608 -31.695 1.00 16.94 ? 1088 ARG A H    1 
ATOM   50   H HA   . ARG A 1 10 ? 15.316  21.087 -29.480 1.00 17.70 ? 1088 ARG A HA   1 
ATOM   51   H HB2  . ARG A 1 10 ? 16.731  21.922 -31.127 1.00 16.42 ? 1088 ARG A HB2  1 
ATOM   52   H HB3  . ARG A 1 10 ? 15.823  23.218 -31.267 1.00 16.42 ? 1088 ARG A HB3  1 
ATOM   53   H HG2  . ARG A 1 10 ? 16.481  23.943 -29.156 1.00 17.91 ? 1088 ARG A HG2  1 
ATOM   54   H HG3  . ARG A 1 10 ? 17.319  22.611 -28.936 1.00 17.91 ? 1088 ARG A HG3  1 
ATOM   55   H HD2  . ARG A 1 10 ? 18.827  24.304 -29.526 1.00 12.96 ? 1088 ARG A HD2  1 
ATOM   56   H HD3  . ARG A 1 10 ? 18.761  23.285 -30.744 1.00 12.96 ? 1088 ARG A HD3  1 
ATOM   57   H HE   . ARG A 1 10 ? 17.730  24.840 -31.944 1.00 12.38 ? 1088 ARG A HE   1 
ATOM   58   H HH11 . ARG A 1 10 ? 18.307  26.086 -28.938 1.00 11.41 ? 1088 ARG A HH11 1 
ATOM   59   H HH12 . ARG A 1 10 ? 17.950  27.490 -29.284 1.00 11.41 ? 1088 ARG A HH12 1 
ATOM   60   H HH21 . ARG A 1 10 ? 17.103  26.952 -32.416 1.00 13.04 ? 1088 ARG A HH21 1 
ATOM   61   H HH22 . ARG A 1 10 ? 17.223  28.015 -31.379 1.00 13.04 ? 1088 ARG A HH22 1 
ATOM   62   N N    . ARG A 1 11 ? 13.169  23.428 -29.829 1.00 10.62 ? 1089 ARG A N    1 
ATOM   63   C CA   . ARG A 1 11 ? 12.330  24.356 -29.081 1.00 10.28 ? 1089 ARG A CA   1 
ATOM   64   C C    . ARG A 1 11 ? 10.867  24.002 -29.276 1.00 10.08 ? 1089 ARG A C    1 
ATOM   65   O O    . ARG A 1 11 ? 10.426  23.728 -30.398 1.00 14.02 ? 1089 ARG A O    1 
ATOM   66   C CB   . ARG A 1 11 ? 12.573  25.820 -29.460 1.00 11.00 ? 1089 ARG A CB   1 
ATOM   67   C CG   . ARG A 1 11 ? 14.007  26.247 -29.370 1.00 13.77 ? 1089 ARG A CG   1 
ATOM   68   C CD   . ARG A 1 11 ? 14.187  27.651 -29.910 1.00 18.56 ? 1089 ARG A CD   1 
ATOM   69   N NE   . ARG A 1 11 ? 13.672  28.706 -29.043 1.00 12.23 ? 1089 ARG A NE   1 
ATOM   70   C CZ   . ARG A 1 11 ? 12.677  29.513 -29.376 1.00 17.84 ? 1089 ARG A CZ   1 
ATOM   71   N NH1  . ARG A 1 11 ? 12.040  29.373 -30.522 1.00 28.02 ? 1089 ARG A NH1  1 
ATOM   72   N NH2  . ARG A 1 11 ? 12.343  30.510 -28.559 1.00 19.90 ? 1089 ARG A NH2  1 
ATOM   73   H H    . ARG A 1 11 ? 12.993  23.394 -30.670 1.00 12.89 ? 1089 ARG A H    1 
ATOM   74   H HA   . ARG A 1 11 ? 12.551  24.262 -28.141 1.00 12.48 ? 1089 ARG A HA   1 
ATOM   75   H HB2  . ARG A 1 11 ? 12.282  25.955 -30.375 1.00 13.34 ? 1089 ARG A HB2  1 
ATOM   76   H HB3  . ARG A 1 11 ? 12.059  26.384 -28.862 1.00 13.34 ? 1089 ARG A HB3  1 
ATOM   77   H HG2  . ARG A 1 11 ? 14.291  26.235 -28.442 1.00 16.68 ? 1089 ARG A HG2  1 
ATOM   78   H HG3  . ARG A 1 11 ? 14.558  25.643 -29.892 1.00 16.68 ? 1089 ARG A HG3  1 
ATOM   79   H HD2  . ARG A 1 11 ? 15.135  27.814 -30.037 1.00 22.41 ? 1089 ARG A HD2  1 
ATOM   80   H HD3  . ARG A 1 11 ? 13.722  27.718 -30.759 1.00 22.41 ? 1089 ARG A HD3  1 
ATOM   81   H HE   . ARG A 1 11 ? 14.037  28.809 -28.271 1.00 14.82 ? 1089 ARG A HE   1 
ATOM   82   H HH11 . ARG A 1 11 ? 12.268  28.749 -31.068 1.00 33.77 ? 1089 ARG A HH11 1 
ATOM   83   H HH12 . ARG A 1 11 ? 11.395  29.906 -30.723 1.00 33.77 ? 1089 ARG A HH12 1 
ATOM   84   H HH21 . ARG A 1 11 ? 12.772  30.626 -27.823 1.00 24.03 ? 1089 ARG A HH21 1 
ATOM   85   H HH22 . ARG A 1 11 ? 11.697  31.039 -28.768 1.00 24.03 ? 1089 ARG A HH22 1 
ATOM   86   N N    . VAL A 1 12 ? 10.115  23.974 -28.176 1.00 9.05  ? 1090 VAL A N    1 
ATOM   87   C CA   . VAL A 1 12 ? 8.675   23.739 -28.230 1.00 9.35  ? 1090 VAL A CA   1 
ATOM   88   C C    . VAL A 1 12 ? 7.995   24.817 -27.409 1.00 7.56  ? 1090 VAL A C    1 
ATOM   89   O O    . VAL A 1 12 ? 8.617   25.510 -26.606 1.00 7.29  ? 1090 VAL A O    1 
ATOM   90   C CB   . VAL A 1 12 ? 8.232   22.332 -27.757 1.00 6.90  ? 1090 VAL A CB   1 
ATOM   91   C CG1  . VAL A 1 12 ? 8.798   21.276 -28.674 1.00 7.65  ? 1090 VAL A CG1  1 
ATOM   92   C CG2  . VAL A 1 12 ? 8.689   22.055 -26.322 1.00 7.34  ? 1090 VAL A CG2  1 
ATOM   93   H H    . VAL A 1 12 ? 10.421  24.090 -27.381 1.00 11.01 ? 1090 VAL A H    1 
ATOM   94   H HA   . VAL A 1 12 ? 8.392   23.812 -29.155 1.00 11.37 ? 1090 VAL A HA   1 
ATOM   95   H HB   . VAL A 1 12 ? 7.263   22.298 -27.780 1.00 8.42  ? 1090 VAL A HB   1 
ATOM   96   H HG11 . VAL A 1 12 ? 8.298   20.454 -28.556 1.00 9.32  ? 1090 VAL A HG11 1 
ATOM   97   H HG12 . VAL A 1 12 ? 8.721   21.581 -29.592 1.00 9.32  ? 1090 VAL A HG12 1 
ATOM   98   H HG13 . VAL A 1 12 ? 9.731   21.132 -28.451 1.00 9.32  ? 1090 VAL A HG13 1 
ATOM   99   H HG21 . VAL A 1 12 ? 8.531   21.120 -26.115 1.00 8.96  ? 1090 VAL A HG21 1 
ATOM   100  H HG22 . VAL A 1 12 ? 9.635   22.254 -26.247 1.00 8.96  ? 1090 VAL A HG22 1 
ATOM   101  H HG23 . VAL A 1 12 ? 8.183   22.618 -25.715 1.00 8.96  ? 1090 VAL A HG23 1 
ATOM   102  N N    . LYS A 1 13 ? 6.720   25.014 -27.692 1.00 6.81  ? 1091 LYS A N    1 
ATOM   103  C CA   . LYS A 1 13 ? 5.931   25.975 -26.963 1.00 9.94  ? 1091 LYS A CA   1 
ATOM   104  C C    . LYS A 1 13 ? 4.778   25.215 -26.348 1.00 7.09  ? 1091 LYS A C    1 
ATOM   105  O O    . LYS A 1 13 ? 4.103   24.452 -27.043 1.00 8.81  ? 1091 LYS A O    1 
ATOM   106  C CB   . LYS A 1 13 ? 5.426   27.096 -27.871 1.00 13.87 ? 1091 LYS A CB   1 
ATOM   107  C CG   . LYS A 1 13 ? 4.355   27.851 -27.192 1.00 24.54 ? 1091 LYS A CG   1 
ATOM   108  C CD   . LYS A 1 13 ? 4.657   29.330 -27.116 1.00 27.67 ? 1091 LYS A CD   1 
ATOM   109  C CE   . LYS A 1 13 ? 4.212   30.015 -28.388 1.00 35.40 ? 1091 LYS A CE   1 
ATOM   110  N NZ   . LYS A 1 13 ? 4.103   31.485 -28.144 1.00 49.28 ? 1091 LYS A NZ   1 
ATOM   111  H H    . LYS A 1 13 ? 6.291   24.596 -28.309 1.00 8.31  ? 1091 LYS A H    1 
ATOM   112  H HA   . LYS A 1 13 ? 6.454   26.399 -26.265 1.00 12.07 ? 1091 LYS A HA   1 
ATOM   113  H HB2  . LYS A 1 13 ? 6.154   27.703 -28.075 1.00 16.79 ? 1091 LYS A HB2  1 
ATOM   114  H HB3  . LYS A 1 13 ? 5.070   26.718 -28.690 1.00 16.79 ? 1091 LYS A HB3  1 
ATOM   115  H HG2  . LYS A 1 13 ? 3.526   27.737 -27.681 1.00 29.59 ? 1091 LYS A HG2  1 
ATOM   116  H HG3  . LYS A 1 13 ? 4.255   27.517 -26.287 1.00 29.59 ? 1091 LYS A HG3  1 
ATOM   117  H HD2  . LYS A 1 13 ? 4.180   29.722 -26.368 1.00 33.35 ? 1091 LYS A HD2  1 
ATOM   118  H HD3  . LYS A 1 13 ? 5.611   29.464 -27.008 1.00 33.35 ? 1091 LYS A HD3  1 
ATOM   119  H HE2  . LYS A 1 13 ? 4.862   29.860 -29.090 1.00 42.63 ? 1091 LYS A HE2  1 
ATOM   120  H HE3  . LYS A 1 13 ? 3.344   29.676 -28.658 1.00 42.63 ? 1091 LYS A HE3  1 
ATOM   121  H HZ1  . LYS A 1 13 ? 3.833   31.898 -28.885 1.00 59.28 ? 1091 LYS A HZ1  1 
ATOM   122  H HZ2  . LYS A 1 13 ? 3.515   31.644 -27.495 1.00 59.28 ? 1091 LYS A HZ2  1 
ATOM   123  H HZ3  . LYS A 1 13 ? 4.894   31.813 -27.903 1.00 59.28 ? 1091 LYS A HZ3  1 
ATOM   124  N N    . THR A 1 14 ? 4.560   25.407 -25.057 1.00 7.89  ? 1092 THR A N    1 
ATOM   125  C CA   . THR A 1 14 ? 3.511   24.671 -24.365 1.00 6.03  ? 1092 THR A CA   1 
ATOM   126  C C    . THR A 1 14 ? 2.129   25.209 -24.718 1.00 7.22  ? 1092 THR A C    1 
ATOM   127  O O    . THR A 1 14 ? 1.911   26.418 -24.798 1.00 5.43  ? 1092 THR A O    1 
ATOM   128  C CB   . THR A 1 14 ? 3.724   24.737 -22.863 1.00 6.60  ? 1092 THR A CB   1 
ATOM   129  O OG1  . THR A 1 14 ? 3.689   26.102 -22.431 1.00 10.03 ? 1092 THR A OG1  1 
ATOM   130  C CG2  . THR A 1 14 ? 5.064   24.085 -22.490 1.00 6.76  ? 1092 THR A CG2  1 
ATOM   131  H H    . THR A 1 14 ? 5.002   25.954 -24.561 1.00 9.61  ? 1092 THR A H    1 
ATOM   132  H HA   . THR A 1 14 ? 3.545   23.743 -24.643 1.00 7.38  ? 1092 THR A HA   1 
ATOM   133  H HB   . THR A 1 14 ? 3.020   24.252 -22.404 1.00 8.06  ? 1092 THR A HB   1 
ATOM   134  H HG1  . THR A 1 14 ? 3.681   26.138 -21.592 1.00 12.19 ? 1092 THR A HG1  1 
ATOM   135  H HG21 . THR A 1 14 ? 5.309   24.326 -21.583 1.00 8.26  ? 1092 THR A HG21 1 
ATOM   136  H HG22 . THR A 1 14 ? 4.991   23.119 -22.550 1.00 8.26  ? 1092 THR A HG22 1 
ATOM   137  H HG23 . THR A 1 14 ? 5.759   24.386 -23.095 1.00 8.26  ? 1092 THR A HG23 1 
ATOM   138  N N    . ILE A 1 15 ? 1.174   24.296 -24.859 1.00 7.30  ? 1093 ILE A N    1 
ATOM   139  C CA   . ILE A 1 15 ? -0.175  24.654 -25.262 1.00 8.31  ? 1093 ILE A CA   1 
ATOM   140  C C    . ILE A 1 15 ? -1.227  24.345 -24.212 1.00 10.36 ? 1093 ILE A C    1 
ATOM   141  O O    . ILE A 1 15 ? -2.388  24.759 -24.388 1.00 9.38  ? 1093 ILE A O    1 
ATOM   142  C CB   . ILE A 1 15 ? -0.549  23.978 -26.593 1.00 9.01  ? 1093 ILE A CB   1 
ATOM   143  C CG1  . ILE A 1 15 ? -0.368  22.474 -26.492 1.00 13.44 ? 1093 ILE A CG1  1 
ATOM   144  C CG2  . ILE A 1 15 ? 0.306   24.554 -27.687 1.00 12.19 ? 1093 ILE A CG2  1 
ATOM   145  C CD1  . ILE A 1 15 ? -1.153  21.751 -27.548 1.00 17.13 ? 1093 ILE A CD1  1 
ATOM   146  H H    . ILE A 1 15 ? 1.287   23.454 -24.725 1.00 8.90  ? 1093 ILE A H    1 
ATOM   147  H HA   . ILE A 1 15 ? -0.199  25.614 -25.395 1.00 10.12 ? 1093 ILE A HA   1 
ATOM   148  H HB   . ILE A 1 15 ? -1.483  24.147 -26.795 1.00 10.96 ? 1093 ILE A HB   1 
ATOM   149  H HG12 . ILE A 1 15 ? 0.571   22.256 -26.606 1.00 16.27 ? 1093 ILE A HG12 1 
ATOM   150  H HG13 . ILE A 1 15 ? -0.675  22.172 -25.623 1.00 16.27 ? 1093 ILE A HG13 1 
ATOM   151  H HG21 . ILE A 1 15 ? 0.270   23.968 -28.458 1.00 14.77 ? 1093 ILE A HG21 1 
ATOM   152  H HG22 . ILE A 1 15 ? -0.032  25.432 -27.923 1.00 14.77 ? 1093 ILE A HG22 1 
ATOM   153  H HG23 . ILE A 1 15 ? 1.220   24.626 -27.368 1.00 14.77 ? 1093 ILE A HG23 1 
ATOM   154  H HD11 . ILE A 1 15 ? -1.092  20.797 -27.388 1.00 20.70 ? 1093 ILE A HD11 1 
ATOM   155  H HD12 . ILE A 1 15 ? -2.079  22.036 -27.503 1.00 20.70 ? 1093 ILE A HD12 1 
ATOM   156  H HD13 . ILE A 1 15 ? -0.782  21.965 -28.418 1.00 20.70 ? 1093 ILE A HD13 1 
ATOM   157  N N    . TYR A 1 16 ? -0.862  23.650 -23.123 1.00 7.79  ? 1094 TYR A N    1 
ATOM   158  C CA   . TYR A 1 16 ? -1.705  23.464 -21.954 1.00 12.33 ? 1094 TYR A CA   1 
ATOM   159  C C    . TYR A 1 16 ? -0.859  23.703 -20.714 1.00 12.71 ? 1094 TYR A C    1 
ATOM   160  O O    . TYR A 1 16 ? 0.377   23.733 -20.774 1.00 9.26  ? 1094 TYR A O    1 
ATOM   161  C CB   . TYR A 1 16 ? -2.326  22.057 -21.874 1.00 11.91 ? 1094 TYR A CB   1 
ATOM   162  C CG   . TYR A 1 16 ? -3.180  21.726 -23.059 1.00 11.66 ? 1094 TYR A CG   1 
ATOM   163  C CD1  . TYR A 1 16 ? -4.363  22.402 -23.300 1.00 13.81 ? 1094 TYR A CD1  1 
ATOM   164  C CD2  . TYR A 1 16 ? -2.808  20.732 -23.939 1.00 19.44 ? 1094 TYR A CD2  1 
ATOM   165  C CE1  . TYR A 1 16 ? -5.149  22.098 -24.398 1.00 14.40 ? 1094 TYR A CE1  1 
ATOM   166  C CE2  . TYR A 1 16 ? -3.565  20.435 -25.036 1.00 19.76 ? 1094 TYR A CE2  1 
ATOM   167  C CZ   . TYR A 1 16 ? -4.738  21.116 -25.262 1.00 18.88 ? 1094 TYR A CZ   1 
ATOM   168  O OH   . TYR A 1 16 ? -5.488  20.800 -26.354 1.00 25.27 ? 1094 TYR A OH   1 
ATOM   169  H H    . TYR A 1 16 ? -0.097  23.265 -23.044 1.00 9.49  ? 1094 TYR A H    1 
ATOM   170  H HA   . TYR A 1 16 ? -2.433  24.104 -21.993 1.00 14.94 ? 1094 TYR A HA   1 
ATOM   171  H HB2  . TYR A 1 16 ? -1.614  21.401 -21.826 1.00 14.44 ? 1094 TYR A HB2  1 
ATOM   172  H HB3  . TYR A 1 16 ? -2.882  22.003 -21.080 1.00 14.44 ? 1094 TYR A HB3  1 
ATOM   173  H HD1  . TYR A 1 16 ? -4.634  23.072 -22.715 1.00 16.72 ? 1094 TYR A HD1  1 
ATOM   174  H HD2  . TYR A 1 16 ? -2.026  20.253 -23.783 1.00 23.48 ? 1094 TYR A HD2  1 
ATOM   175  H HE1  . TYR A 1 16 ? -5.946  22.553 -24.547 1.00 17.43 ? 1094 TYR A HE1  1 
ATOM   176  H HE2  . TYR A 1 16 ? -3.288  19.775 -25.630 1.00 23.86 ? 1094 TYR A HE2  1 
ATOM   177  H HH   . TYR A 1 16 ? -6.154  21.310 -26.403 1.00 30.47 ? 1094 TYR A HH   1 
ATOM   178  N N    . ASP A 1 17 ? -1.542  23.940 -19.603 1.00 8.66  ? 1095 ASP A N    1 
ATOM   179  C CA   . ASP A 1 17 ? -0.915  23.853 -18.291 1.00 7.57  ? 1095 ASP A CA   1 
ATOM   180  C C    . ASP A 1 17 ? -0.583  22.403 -17.986 1.00 6.58  ? 1095 ASP A C    1 
ATOM   181  O O    . ASP A 1 17 ? -1.196  21.489 -18.524 1.00 7.94  ? 1095 ASP A O    1 
ATOM   182  C CB   . ASP A 1 17 ? -1.848  24.383 -17.221 1.00 10.53 ? 1095 ASP A CB   1 
ATOM   183  C CG   . ASP A 1 17 ? -2.073  25.869 -17.311 1.00 16.88 ? 1095 ASP A CG   1 
ATOM   184  O OD1  . ASP A 1 17 ? -1.421  26.561 -18.141 1.00 12.11 ? 1095 ASP A OD1  1 
ATOM   185  O OD2  . ASP A 1 17 ? -2.956  26.345 -16.571 1.00 18.41 ? 1095 ASP A OD2  1 
ATOM   186  H H    . ASP A 1 17 ? -2.374  24.154 -19.580 1.00 10.53 ? 1095 ASP A H    1 
ATOM   187  H HA   . ASP A 1 17 ? -0.103  24.385 -18.276 1.00 9.23  ? 1095 ASP A HA   1 
ATOM   188  H HB2  . ASP A 1 17 ? -2.709  23.945 -17.311 1.00 12.79 ? 1095 ASP A HB2  1 
ATOM   189  H HB3  . ASP A 1 17 ? -1.468  24.191 -16.350 1.00 12.79 ? 1095 ASP A HB3  1 
ATOM   190  N N    . CYS A 1 18 ? 0.410   22.187 -17.127 1.00 9.26  ? 1096 CYS A N    1 
ATOM   191  C CA   . CYS A 1 18 ? 0.816   20.834 -16.763 1.00 11.13 ? 1096 CYS A CA   1 
ATOM   192  C C    . CYS A 1 18 ? 1.457   20.873 -15.383 1.00 12.85 ? 1096 CYS A C    1 
ATOM   193  O O    . CYS A 1 18 ? 2.411   21.630 -15.167 1.00 11.53 ? 1096 CYS A O    1 
ATOM   194  C CB   . CYS A 1 18 ? 1.787   20.267 -17.782 1.00 12.98 ? 1096 CYS A CB   1 
ATOM   195  S SG   . CYS A 1 18 ? 2.231   18.576 -17.455 1.00 11.66 ? 1096 CYS A SG   1 
ATOM   196  H H    . CYS A 1 18 ? 0.864   22.808 -16.743 1.00 11.26 ? 1096 CYS A H    1 
ATOM   197  H HA   . CYS A 1 18 ? 0.034   20.261 -16.725 1.00 13.51 ? 1096 CYS A HA   1 
ATOM   198  H HB2  . CYS A 1 18 ? 1.378   20.305 -18.661 1.00 15.72 ? 1096 CYS A HB2  1 
ATOM   199  H HB3  . CYS A 1 18 ? 2.599   20.797 -17.770 1.00 15.72 ? 1096 CYS A HB3  1 
ATOM   200  H HG   . CYS A 1 18 ? 2.806   18.520 -16.403 1.00 14.14 ? 1096 CYS A HG   1 
ATOM   201  N N    . GLN A 1 19 ? 0.898   20.106 -14.448 1.00 9.56  ? 1097 GLN A N    1 
ATOM   202  C CA   . GLN A 1 19 ? 1.464   19.922 -13.116 1.00 12.32 ? 1097 GLN A CA   1 
ATOM   203  C C    . GLN A 1 19 ? 2.081   18.537 -13.056 1.00 12.64 ? 1097 GLN A C    1 
ATOM   204  O O    . GLN A 1 19 ? 1.464   17.541 -13.464 1.00 11.37 ? 1097 GLN A O    1 
ATOM   205  C CB   . GLN A 1 19 ? 0.405   20.097 -12.031 1.00 15.80 ? 1097 GLN A CB   1 
ATOM   206  C CG   . GLN A 1 19 ? 0.793   19.692 -10.612 1.00 15.59 ? 1097 GLN A CG   1 
ATOM   207  C CD   . GLN A 1 19 ? 1.954   20.436 -9.938  1.00 38.98 ? 1097 GLN A CD   1 
ATOM   208  O OE1  . GLN A 1 19 ? 3.049   19.892 -9.692  1.00 32.97 ? 1097 GLN A OE1  1 
ATOM   209  N NE2  . GLN A 1 19 ? 1.685   21.719 -9.597  1.00 34.43 ? 1097 GLN A NE2  1 
ATOM   210  H H    . GLN A 1 19 ? 0.167   19.669 -14.567 1.00 11.62 ? 1097 GLN A H    1 
ATOM   211  H HA   . GLN A 1 19 ? 2.154   20.582 -12.947 1.00 14.93 ? 1097 GLN A HA   1 
ATOM   212  H HB2  . GLN A 1 19 ? 0.161   21.035 -12.000 1.00 19.11 ? 1097 GLN A HB2  1 
ATOM   213  H HB3  . GLN A 1 19 ? -0.366  19.562 -12.277 1.00 19.11 ? 1097 GLN A HB3  1 
ATOM   214  H HG2  . GLN A 1 19 ? 0.016   19.820 -10.046 1.00 18.85 ? 1097 GLN A HG2  1 
ATOM   215  H HG3  . GLN A 1 19 ? 1.039   18.753 -10.630 1.00 18.85 ? 1097 GLN A HG3  1 
ATOM   216  H HE21 . GLN A 1 19 ? 0.910   22.054 -9.762  1.00 41.47 ? 1097 GLN A HE21 1 
ATOM   217  H HE22 . GLN A 1 19 ? 2.288   22.198 -9.216  1.00 41.47 ? 1097 GLN A HE22 1 
ATOM   218  N N    . ALA A 1 20 ? 3.331   18.490 -12.612 1.00 11.41 ? 1098 ALA A N    1 
ATOM   219  C CA   . ALA A 1 20 ? 4.027   17.225 -12.493 1.00 10.91 ? 1098 ALA A CA   1 
ATOM   220  C C    . ALA A 1 20 ? 3.289   16.284 -11.555 1.00 7.22  ? 1098 ALA A C    1 
ATOM   221  O O    . ALA A 1 20 ? 2.805   16.684 -10.502 1.00 10.83 ? 1098 ALA A O    1 
ATOM   222  C CB   . ALA A 1 20 ? 5.441   17.476 -11.979 1.00 12.77 ? 1098 ALA A CB   1 
ATOM   223  H H    . ALA A 1 20 ? 3.794   19.175 -12.374 1.00 13.83 ? 1098 ALA A H    1 
ATOM   224  H HA   . ALA A 1 20 ? 4.077   16.797 -13.362 1.00 13.24 ? 1098 ALA A HA   1 
ATOM   225  H HB1  . ALA A 1 20 ? 5.834   16.630 -11.711 1.00 15.47 ? 1098 ALA A HB1  1 
ATOM   226  H HB2  . ALA A 1 20 ? 5.969   17.875 -12.689 1.00 15.47 ? 1098 ALA A HB2  1 
ATOM   227  H HB3  . ALA A 1 20 ? 5.399   18.077 -11.220 1.00 15.47 ? 1098 ALA A HB3  1 
ATOM   228  N N    . ASP A 1 21 ? 3.222   15.024 -11.954 1.00 8.36  ? 1099 ASP A N    1 
ATOM   229  C CA   . ASP A 1 21 ? 2.719   13.950 -11.135 1.00 7.54  ? 1099 ASP A CA   1 
ATOM   230  C C    . ASP A 1 21 ? 3.824   13.188 -10.429 1.00 11.38 ? 1099 ASP A C    1 
ATOM   231  O O    . ASP A 1 21 ? 3.546   12.486 -9.463  1.00 12.77 ? 1099 ASP A O    1 
ATOM   232  C CB   . ASP A 1 21 ? 1.943   12.994 -12.017 1.00 9.59  ? 1099 ASP A CB   1 
ATOM   233  C CG   . ASP A 1 21 ? 0.900   13.710 -12.841 1.00 13.99 ? 1099 ASP A CG   1 
ATOM   234  O OD1  . ASP A 1 21 ? 0.140   14.484 -12.231 1.00 21.14 ? 1099 ASP A OD1  1 
ATOM   235  O OD2  . ASP A 1 21 ? 0.852   13.524 -14.093 1.00 18.52 ? 1099 ASP A OD2  1 
ATOM   236  H H    . ASP A 1 21 ? 3.475   14.758 -12.732 1.00 10.17 ? 1099 ASP A H    1 
ATOM   237  H HA   . ASP A 1 21 ? 2.123   14.300 -10.454 1.00 9.19  ? 1099 ASP A HA   1 
ATOM   238  H HB2  . ASP A 1 21 ? 2.557   12.550 -12.624 1.00 11.66 ? 1099 ASP A HB2  1 
ATOM   239  H HB3  . ASP A 1 21 ? 1.494   12.339 -11.461 1.00 11.66 ? 1099 ASP A HB3  1 
ATOM   240  N N    . ASN A 1 22 ? 5.051   13.290 -10.916 1.00 9.53  ? 1100 ASN A N    1 
ATOM   241  C CA   . ASN A 1 22 ? 6.196   12.574 -10.400 1.00 9.11  ? 1100 ASN A CA   1 
ATOM   242  C C    . ASN A 1 22 ? 7.342   13.557 -10.329 1.00 12.67 ? 1100 ASN A C    1 
ATOM   243  O O    . ASN A 1 22 ? 7.354   14.564 -11.024 1.00 8.73  ? 1100 ASN A O    1 
ATOM   244  C CB   . ASN A 1 22 ? 6.579   11.381 -11.298 1.00 14.65 ? 1100 ASN A CB   1 
ATOM   245  C CG   . ASN A 1 22 ? 5.460   10.373 -11.436 1.00 14.90 ? 1100 ASN A CG   1 
ATOM   246  O OD1  . ASN A 1 22 ? 5.236   9.574  -10.541 1.00 17.67 ? 1100 ASN A OD1  1 
ATOM   247  N ND2  . ASN A 1 22 ? 4.760   10.402 -12.563 1.00 12.20 ? 1100 ASN A ND2  1 
ATOM   248  H H    . ASN A 1 22 ? 5.252   13.796 -11.582 1.00 11.59 ? 1100 ASN A H    1 
ATOM   249  H HA   . ASN A 1 22 ? 6.007   12.226 -9.515  1.00 11.07 ? 1100 ASN A HA   1 
ATOM   250  H HB2  . ASN A 1 22 ? 6.799   11.709 -12.184 1.00 17.72 ? 1100 ASN A HB2  1 
ATOM   251  H HB3  . ASN A 1 22 ? 7.345   10.928 -10.912 1.00 17.72 ? 1100 ASN A HB3  1 
ATOM   252  H HD21 . ASN A 1 22 ? 4.114   9.847  -12.683 1.00 14.78 ? 1100 ASN A HD21 1 
ATOM   253  H HD22 . ASN A 1 22 ? 4.951   10.977 -13.174 1.00 14.78 ? 1100 ASN A HD22 1 
ATOM   254  N N    . ASP A 1 23 ? 8.324   13.225 -9.508  1.00 8.78  ? 1101 ASP A N    1 
ATOM   255  C CA   . ASP A 1 23 ? 9.377   14.156 -9.170  1.00 8.84  ? 1101 ASP A CA   1 
ATOM   256  C C    . ASP A 1 23 ? 10.412  14.323 -10.279 1.00 9.40  ? 1101 ASP A C    1 
ATOM   257  O O    . ASP A 1 23 ? 11.370  15.068 -10.077 1.00 13.80 ? 1101 ASP A O    1 
ATOM   258  C CB   . ASP A 1 23 ? 10.049  13.703 -7.859  1.00 12.24 ? 1101 ASP A CB   1 
ATOM   259  C CG   . ASP A 1 23 ? 9.430   14.349 -6.613  1.00 11.16 ? 1101 ASP A CG   1 
ATOM   260  O OD1  . ASP A 1 23 ? 8.777   15.404 -6.743  1.00 13.72 ? 1101 ASP A OD1  1 
ATOM   261  O OD2  . ASP A 1 23 ? 9.621   13.809 -5.496  1.00 14.58 ? 1101 ASP A OD2  1 
ATOM   262  H H    . ASP A 1 23 ? 8.401   12.456 -9.131  1.00 10.68 ? 1101 ASP A H    1 
ATOM   263  H HA   . ASP A 1 23 ? 8.993   15.034 -9.020  1.00 10.76 ? 1101 ASP A HA   1 
ATOM   264  H HB2  . ASP A 1 23 ? 9.957   12.741 -7.773  1.00 14.84 ? 1101 ASP A HB2  1 
ATOM   265  H HB3  . ASP A 1 23 ? 10.988  13.945 -7.886  1.00 14.84 ? 1101 ASP A HB3  1 
ATOM   266  N N    . ASP A 1 24 ? 10.287  13.669 -11.431 1.00 10.63 ? 1102 ASP A N    1 
ATOM   267  C CA   . ASP A 1 24 ? 11.177  14.004 -12.537 1.00 10.70 ? 1102 ASP A CA   1 
ATOM   268  C C    . ASP A 1 24 ? 10.458  14.803 -13.622 1.00 8.51  ? 1102 ASP A C    1 
ATOM   269  O O    . ASP A 1 24 ? 11.049  15.083 -14.665 1.00 8.18  ? 1102 ASP A O    1 
ATOM   270  C CB   . ASP A 1 24 ? 11.817  12.739 -13.130 1.00 6.92  ? 1102 ASP A CB   1 
ATOM   271  C CG   . ASP A 1 24 ? 10.796  11.713 -13.630 1.00 10.77 ? 1102 ASP A CG   1 
ATOM   272  O OD1  . ASP A 1 24 ? 9.589   11.867 -13.315 1.00 11.62 ? 1102 ASP A OD1  1 
ATOM   273  O OD2  . ASP A 1 24 ? 11.240  10.726 -14.278 1.00 15.19 ? 1102 ASP A OD2  1 
ATOM   274  H H    . ASP A 1 24 ? 9.713   13.048 -11.590 1.00 12.91 ? 1102 ASP A H    1 
ATOM   275  H HA   . ASP A 1 24 ? 11.903  14.549 -12.195 1.00 12.98 ? 1102 ASP A HA   1 
ATOM   276  H HB2  . ASP A 1 24 ? 12.375  12.993 -13.882 1.00 8.44  ? 1102 ASP A HB2  1 
ATOM   277  H HB3  . ASP A 1 24 ? 12.357  12.312 -12.446 1.00 8.44  ? 1102 ASP A HB3  1 
ATOM   278  N N    . GLU A 1 25 ? 9.212   15.207 -13.374 1.00 9.49  ? 1103 GLU A N    1 
ATOM   279  C CA   . GLU A 1 25 ? 8.354   15.827 -14.371 1.00 4.96  ? 1103 GLU A CA   1 
ATOM   280  C C    . GLU A 1 25 ? 8.381   17.333 -14.250 1.00 5.00  ? 1103 GLU A C    1 
ATOM   281  O O    . GLU A 1 25 ? 8.426   17.880 -13.146 1.00 10.12 ? 1103 GLU A O    1 
ATOM   282  C CB   . GLU A 1 25 ? 6.916   15.309 -14.234 1.00 5.90  ? 1103 GLU A CB   1 
ATOM   283  C CG   . GLU A 1 25 ? 6.765   13.868 -14.719 1.00 4.89  ? 1103 GLU A CG   1 
ATOM   284  C CD   . GLU A 1 25 ? 5.343   13.314 -14.607 1.00 12.57 ? 1103 GLU A CD   1 
ATOM   285  O OE1  . GLU A 1 25 ? 4.414   14.114 -14.351 1.00 10.76 ? 1103 GLU A OE1  1 
ATOM   286  O OE2  . GLU A 1 25 ? 5.173   12.074 -14.777 1.00 12.13 ? 1103 GLU A OE2  1 
ATOM   287  H H    . GLU A 1 25 ? 8.832   15.128 -12.606 1.00 11.54 ? 1103 GLU A H    1 
ATOM   288  H HA   . GLU A 1 25 ? 8.683   15.605 -15.256 1.00 6.09  ? 1103 GLU A HA   1 
ATOM   289  H HB2  . GLU A 1 25 ? 6.655   15.342 -13.301 1.00 7.23  ? 1103 GLU A HB2  1 
ATOM   290  H HB3  . GLU A 1 25 ? 6.326   15.869 -14.764 1.00 7.23  ? 1103 GLU A HB3  1 
ATOM   291  H HG2  . GLU A 1 25 ? 7.024   13.826 -15.653 1.00 6.02  ? 1103 GLU A HG2  1 
ATOM   292  H HG3  . GLU A 1 25 ? 7.345   13.299 -14.188 1.00 6.02  ? 1103 GLU A HG3  1 
ATOM   293  N N    . LEU A 1 26 ? 8.295   17.995 -15.406 1.00 7.28  ? 1104 LEU A N    1 
ATOM   294  C CA   . LEU A 1 26 ? 8.264   19.448 -15.485 1.00 3.92  ? 1104 LEU A CA   1 
ATOM   295  C C    . LEU A 1 26 ? 6.850   19.969 -15.292 1.00 7.68  ? 1104 LEU A C    1 
ATOM   296  O O    . LEU A 1 26 ? 5.900   19.466 -15.892 1.00 7.30  ? 1104 LEU A O    1 
ATOM   297  C CB   . LEU A 1 26 ? 8.829   19.876 -16.833 1.00 5.00  ? 1104 LEU A CB   1 
ATOM   298  C CG   . LEU A 1 26 ? 8.855   21.382 -17.109 1.00 10.36 ? 1104 LEU A CG   1 
ATOM   299  C CD1  . LEU A 1 26 ? 9.755   22.151 -16.203 1.00 8.55  ? 1104 LEU A CD1  1 
ATOM   300  C CD2  . LEU A 1 26 ? 9.199   21.627 -18.585 1.00 12.63 ? 1104 LEU A CD2  1 
ATOM   301  H H    . LEU A 1 26 ? 8.253   17.612 -16.175 1.00 8.88  ? 1104 LEU A H    1 
ATOM   302  H HA   . LEU A 1 26 ? 8.803   19.837 -14.778 1.00 4.85  ? 1104 LEU A HA   1 
ATOM   303  H HB2  . LEU A 1 26 ? 9.744   19.559 -16.890 1.00 6.15  ? 1104 LEU A HB2  1 
ATOM   304  H HB3  . LEU A 1 26 ? 8.292   19.466 -17.529 1.00 6.15  ? 1104 LEU A HB3  1 
ATOM   305  H HG   . LEU A 1 26 ? 7.969   21.730 -16.923 1.00 12.57 ? 1104 LEU A HG   1 
ATOM   306  H HD11 . LEU A 1 26 ? 9.685   23.095 -16.414 1.00 10.40 ? 1104 LEU A HD11 1 
ATOM   307  H HD12 . LEU A 1 26 ? 9.485   21.996 -15.284 1.00 10.40 ? 1104 LEU A HD12 1 
ATOM   308  H HD13 . LEU A 1 26 ? 10.668  21.849 -16.334 1.00 10.40 ? 1104 LEU A HD13 1 
ATOM   309  H HD21 . LEU A 1 26 ? 9.295   22.581 -18.733 1.00 15.30 ? 1104 LEU A HD21 1 
ATOM   310  H HD22 . LEU A 1 26 ? 10.032  21.175 -18.794 1.00 15.30 ? 1104 LEU A HD22 1 
ATOM   311  H HD23 . LEU A 1 26 ? 8.484   21.276 -19.138 1.00 15.30 ? 1104 LEU A HD23 1 
ATOM   312  N N    . THR A 1 27 ? 6.725   20.975 -14.444 1.00 7.47  ? 1105 THR A N    1 
ATOM   313  C CA   . THR A 1 27 ? 5.505   21.713 -14.195 1.00 10.24 ? 1105 THR A CA   1 
ATOM   314  C C    . THR A 1 27 ? 5.607   23.003 -14.981 1.00 11.43 ? 1105 THR A C    1 
ATOM   315  O O    . THR A 1 27 ? 6.638   23.679 -14.943 1.00 9.38  ? 1105 THR A O    1 
ATOM   316  C CB   . THR A 1 27 ? 5.330   21.997 -12.697 1.00 12.06 ? 1105 THR A CB   1 
ATOM   317  O OG1  . THR A 1 27 ? 5.048   20.784 -12.018 1.00 14.64 ? 1105 THR A OG1  1 
ATOM   318  C CG2  . THR A 1 27 ? 4.203   22.945 -12.431 1.00 12.34 ? 1105 THR A CG2  1 
ATOM   319  H H    . THR A 1 27 ? 7.380   21.267 -13.970 1.00 9.11  ? 1105 THR A H    1 
ATOM   320  H HA   . THR A 1 27 ? 4.724   21.213 -14.479 1.00 12.44 ? 1105 THR A HA   1 
ATOM   321  H HB   . THR A 1 27 ? 6.149   22.399 -12.369 1.00 14.62 ? 1105 THR A HB   1 
ATOM   322  H HG1  . THR A 1 27 ? 5.023   20.918 -11.189 1.00 17.72 ? 1105 THR A HG1  1 
ATOM   323  H HG21 . THR A 1 27 ? 4.012   22.975 -11.481 1.00 14.96 ? 1105 THR A HG21 1 
ATOM   324  H HG22 . THR A 1 27 ? 4.441   23.836 -12.733 1.00 14.96 ? 1105 THR A HG22 1 
ATOM   325  H HG23 . THR A 1 27 ? 3.407   22.655 -12.903 1.00 14.96 ? 1105 THR A HG23 1 
ATOM   326  N N    . PHE A 1 28 ? 4.550   23.325 -15.711 1.00 5.54  ? 1106 PHE A N    1 
ATOM   327  C CA   . PHE A 1 28 ? 4.550   24.510 -16.546 1.00 8.36  ? 1106 PHE A CA   1 
ATOM   328  C C    . PHE A 1 28 ? 3.131   25.004 -16.756 1.00 8.72  ? 1106 PHE A C    1 
ATOM   329  O O    . PHE A 1 28 ? 2.165   24.297 -16.480 1.00 8.44  ? 1106 PHE A O    1 
ATOM   330  C CB   . PHE A 1 28 ? 5.233   24.239 -17.882 1.00 8.83  ? 1106 PHE A CB   1 
ATOM   331  C CG   . PHE A 1 28 ? 4.686   23.067 -18.672 1.00 7.62  ? 1106 PHE A CG   1 
ATOM   332  C CD1  . PHE A 1 28 ? 3.655   23.252 -19.565 1.00 10.76 ? 1106 PHE A CD1  1 
ATOM   333  C CD2  . PHE A 1 28 ? 5.254   21.805 -18.587 1.00 6.15  ? 1106 PHE A CD2  1 
ATOM   334  C CE1  . PHE A 1 28 ? 3.219   22.198 -20.341 1.00 11.01 ? 1106 PHE A CE1  1 
ATOM   335  C CE2  . PHE A 1 28 ? 4.779   20.735 -19.324 1.00 7.22  ? 1106 PHE A CE2  1 
ATOM   336  C CZ   . PHE A 1 28 ? 3.798   20.928 -20.224 1.00 10.14 ? 1106 PHE A CZ   1 
ATOM   337  H H    . PHE A 1 28 ? 3.820   22.872 -15.738 1.00 6.80  ? 1106 PHE A H    1 
ATOM   338  H HA   . PHE A 1 28 ? 5.031   25.217 -16.087 1.00 10.18 ? 1106 PHE A HA   1 
ATOM   339  H HB2  . PHE A 1 28 ? 5.139   25.029 -18.438 1.00 10.74 ? 1106 PHE A HB2  1 
ATOM   340  H HB3  . PHE A 1 28 ? 6.171   24.061 -17.715 1.00 10.74 ? 1106 PHE A HB3  1 
ATOM   341  H HD1  . PHE A 1 28 ? 3.252   24.086 -19.646 1.00 13.06 ? 1106 PHE A HD1  1 
ATOM   342  H HD2  . PHE A 1 28 ? 5.977   21.674 -18.016 1.00 7.53  ? 1106 PHE A HD2  1 
ATOM   343  H HE1  . PHE A 1 28 ? 2.530   22.332 -20.951 1.00 13.36 ? 1106 PHE A HE1  1 
ATOM   344  H HE2  . PHE A 1 28 ? 5.137   19.886 -19.198 1.00 8.81  ? 1106 PHE A HE2  1 
ATOM   345  H HZ   . PHE A 1 28 ? 3.508   20.227 -20.763 1.00 12.32 ? 1106 PHE A HZ   1 
ATOM   346  N N    . ILE A 1 29 ? 3.024   26.242 -17.228 1.00 12.58 ? 1107 ILE A N    1 
ATOM   347  C CA   . ILE A 1 29 ? 1.769   26.785 -17.718 1.00 10.37 ? 1107 ILE A CA   1 
ATOM   348  C C    . ILE A 1 29 ? 1.847   26.871 -19.235 1.00 11.84 ? 1107 ILE A C    1 
ATOM   349  O O    . ILE A 1 29 ? 2.916   26.730 -19.853 1.00 11.23 ? 1107 ILE A O    1 
ATOM   350  C CB   . ILE A 1 29 ? 1.435   28.164 -17.108 1.00 8.60  ? 1107 ILE A CB   1 
ATOM   351  C CG1  . ILE A 1 29 ? 2.541   29.182 -17.390 1.00 15.62 ? 1107 ILE A CG1  1 
ATOM   352  C CG2  . ILE A 1 29 ? 1.202   28.041 -15.613 1.00 18.55 ? 1107 ILE A CG2  1 
ATOM   353  C CD1  . ILE A 1 29 ? 2.168   30.604 -17.100 1.00 12.01 ? 1107 ILE A CD1  1 
ATOM   354  H H    . ILE A 1 29 ? 3.680   26.796 -17.275 1.00 15.24 ? 1107 ILE A H    1 
ATOM   355  H HA   . ILE A 1 29 ? 1.054   26.177 -17.472 1.00 12.59 ? 1107 ILE A HA   1 
ATOM   356  H HB   . ILE A 1 29 ? 0.621   28.481 -17.530 1.00 10.46 ? 1107 ILE A HB   1 
ATOM   357  H HG12 . ILE A 1 29 ? 3.310   28.963 -16.841 1.00 18.89 ? 1107 ILE A HG12 1 
ATOM   358  H HG13 . ILE A 1 29 ? 2.778   29.127 -18.330 1.00 18.89 ? 1107 ILE A HG13 1 
ATOM   359  H HG21 . ILE A 1 29 ? 0.944   28.907 -15.262 1.00 22.40 ? 1107 ILE A HG21 1 
ATOM   360  H HG22 . ILE A 1 29 ? 0.496   27.396 -15.455 1.00 22.40 ? 1107 ILE A HG22 1 
ATOM   361  H HG23 . ILE A 1 29 ? 2.023   27.743 -15.189 1.00 22.40 ? 1107 ILE A HG23 1 
ATOM   362  H HD11 . ILE A 1 29 ? 2.893   31.184 -17.381 1.00 14.56 ? 1107 ILE A HD11 1 
ATOM   363  H HD12 . ILE A 1 29 ? 1.360   30.825 -17.589 1.00 14.56 ? 1107 ILE A HD12 1 
ATOM   364  H HD13 . ILE A 1 29 ? 2.016   30.702 -16.147 1.00 14.56 ? 1107 ILE A HD13 1 
ATOM   365  N N    . GLU A 1 30 ? 0.689   27.100 -19.835 1.00 8.87  ? 1108 GLU A N    1 
ATOM   366  C CA   . GLU A 1 30 ? 0.577   27.329 -21.264 1.00 6.01  ? 1108 GLU A CA   1 
ATOM   367  C C    . GLU A 1 30 ? 1.371   28.559 -21.676 1.00 6.24  ? 1108 GLU A C    1 
ATOM   368  O O    . GLU A 1 30 ? 1.512   29.519 -20.912 1.00 7.50  ? 1108 GLU A O    1 
ATOM   369  C CB   . GLU A 1 30 ? -0.894  27.525 -21.628 1.00 8.20  ? 1108 GLU A CB   1 
ATOM   370  C CG   . GLU A 1 30 ? -1.173  27.632 -23.087 1.00 8.58  ? 1108 GLU A CG   1 
ATOM   371  C CD   . GLU A 1 30 ? -1.018  29.030 -23.664 1.00 10.86 ? 1108 GLU A CD   1 
ATOM   372  O OE1  . GLU A 1 30 ? -0.685  29.981 -22.915 1.00 11.59 ? 1108 GLU A OE1  1 
ATOM   373  O OE2  . GLU A 1 30 ? -1.287  29.175 -24.893 1.00 15.21 ? 1108 GLU A OE2  1 
ATOM   374  H H    . GLU A 1 30 ? -0.067  27.128 -19.426 1.00 10.78 ? 1108 GLU A H    1 
ATOM   375  H HA   . GLU A 1 30 ? 0.929   26.566 -21.749 1.00 7.36  ? 1108 GLU A HA   1 
ATOM   376  H HB2  . GLU A 1 30 ? -1.397  26.768 -21.291 1.00 9.99  ? 1108 GLU A HB2  1 
ATOM   377  H HB3  . GLU A 1 30 ? -1.207  28.344 -21.212 1.00 9.99  ? 1108 GLU A HB3  1 
ATOM   378  H HG2  . GLU A 1 30 ? -0.558  27.051 -23.562 1.00 10.45 ? 1108 GLU A HG2  1 
ATOM   379  H HG3  . GLU A 1 30 ? -2.087  27.350 -23.248 1.00 10.45 ? 1108 GLU A HG3  1 
ATOM   380  N N    . GLY A 1 31 ? 1.859   28.534 -22.919 1.00 5.43  ? 1109 GLY A N    1 
ATOM   381  C CA   . GLY A 1 31 ? 2.585   29.631 -23.487 1.00 6.97  ? 1109 GLY A CA   1 
ATOM   382  C C    . GLY A 1 31 ? 4.081   29.678 -23.214 1.00 11.35 ? 1109 GLY A C    1 
ATOM   383  O O    . GLY A 1 31 ? 4.734   30.642 -23.631 1.00 12.16 ? 1109 GLY A O    1 
ATOM   384  H H    . GLY A 1 31 ? 1.771   27.867 -23.455 1.00 6.66  ? 1109 GLY A H    1 
ATOM   385  H HA2  . GLY A 1 31 ? 2.469   29.605 -24.450 1.00 8.51  ? 1109 GLY A HA2  1 
ATOM   386  H HA3  . GLY A 1 31 ? 2.205   30.456 -23.146 1.00 8.51  ? 1109 GLY A HA3  1 
ATOM   387  N N    . GLU A 1 32 ? 4.656   28.701 -22.519 1.00 9.24  ? 1110 GLU A N    1 
ATOM   388  C CA   . GLU A 1 32 ? 6.086   28.766 -22.214 1.00 8.46  ? 1110 GLU A CA   1 
ATOM   389  C C    . GLU A 1 32 ? 6.890   28.020 -23.258 1.00 4.39  ? 1110 GLU A C    1 
ATOM   390  O O    . GLU A 1 32 ? 6.450   27.011 -23.796 1.00 4.80  ? 1110 GLU A O    1 
ATOM   391  C CB   . GLU A 1 32 ? 6.401   28.162 -20.842 1.00 5.70  ? 1110 GLU A CB   1 
ATOM   392  C CG   . GLU A 1 32 ? 5.586   28.753 -19.718 1.00 7.88  ? 1110 GLU A CG   1 
ATOM   393  C CD   . GLU A 1 32 ? 6.146   28.414 -18.346 1.00 12.02 ? 1110 GLU A CD   1 
ATOM   394  O OE1  . GLU A 1 32 ? 7.174   29.016 -17.970 1.00 12.20 ? 1110 GLU A OE1  1 
ATOM   395  O OE2  . GLU A 1 32 ? 5.558   27.547 -17.659 1.00 10.02 ? 1110 GLU A OE2  1 
ATOM   396  H H    . GLU A 1 32 ? 4.250   28.004 -22.219 1.00 11.23 ? 1110 GLU A H    1 
ATOM   397  H HA   . GLU A 1 32 ? 6.349   29.699 -22.207 1.00 10.30 ? 1110 GLU A HA   1 
ATOM   398  H HB2  . GLU A 1 32 ? 6.220   27.210 -20.871 1.00 6.99  ? 1110 GLU A HB2  1 
ATOM   399  H HB3  . GLU A 1 32 ? 7.338   28.316 -20.642 1.00 6.99  ? 1110 GLU A HB3  1 
ATOM   400  H HG2  . GLU A 1 32 ? 5.576   29.719 -19.807 1.00 9.60  ? 1110 GLU A HG2  1 
ATOM   401  H HG3  . GLU A 1 32 ? 4.682   28.406 -19.767 1.00 9.60  ? 1110 GLU A HG3  1 
ATOM   402  N N    . VAL A 1 33 ? 8.110   28.467 -23.475 1.00 9.69  ? 1111 VAL A N    1 
ATOM   403  C CA   . VAL A 1 33 ? 9.027   27.780 -24.383 1.00 8.86  ? 1111 VAL A CA   1 
ATOM   404  C C    . VAL A 1 33 ? 9.896   26.803 -23.599 1.00 3.65  ? 1111 VAL A C    1 
ATOM   405  O O    . VAL A 1 33 ? 10.439  27.141 -22.540 1.00 6.41  ? 1111 VAL A O    1 
ATOM   406  C CB   . VAL A 1 33 ? 9.871   28.798 -25.168 1.00 9.16  ? 1111 VAL A CB   1 
ATOM   407  C CG1  . VAL A 1 33 ? 10.967  28.125 -25.978 1.00 9.78  ? 1111 VAL A CG1  1 
ATOM   408  C CG2  . VAL A 1 33 ? 8.971   29.641 -26.068 1.00 12.99 ? 1111 VAL A CG2  1 
ATOM   409  H H    . VAL A 1 33 ? 8.439   29.173 -23.110 1.00 11.77 ? 1111 VAL A H    1 
ATOM   410  H HA   . VAL A 1 33 ? 8.514   27.253 -25.016 1.00 10.78 ? 1111 VAL A HA   1 
ATOM   411  H HB   . VAL A 1 33 ? 10.312  29.382 -24.532 1.00 11.14 ? 1111 VAL A HB   1 
ATOM   412  H HG11 . VAL A 1 33 ? 11.356  28.774 -26.584 1.00 11.89 ? 1111 VAL A HG11 1 
ATOM   413  H HG12 . VAL A 1 33 ? 11.646  27.789 -25.372 1.00 11.89 ? 1111 VAL A HG12 1 
ATOM   414  H HG13 . VAL A 1 33 ? 10.581  27.391 -26.482 1.00 11.89 ? 1111 VAL A HG13 1 
ATOM   415  H HG21 . VAL A 1 33 ? 9.521   30.256 -26.578 1.00 15.74 ? 1111 VAL A HG21 1 
ATOM   416  H HG22 . VAL A 1 33 ? 8.487   29.054 -26.669 1.00 15.74 ? 1111 VAL A HG22 1 
ATOM   417  H HG23 . VAL A 1 33 ? 8.347   30.136 -25.514 1.00 15.74 ? 1111 VAL A HG23 1 
ATOM   418  N N    . ILE A 1 34 ? 9.980   25.571 -24.102 1.00 5.23  ? 1112 ILE A N    1 
ATOM   419  C CA   . ILE A 1 34 ? 10.843  24.531 -23.568 1.00 5.97  ? 1112 ILE A CA   1 
ATOM   420  C C    . ILE A 1 34 ? 11.981  24.262 -24.552 1.00 5.71  ? 1112 ILE A C    1 
ATOM   421  O O    . ILE A 1 34 ? 11.769  24.129 -25.763 1.00 7.41  ? 1112 ILE A O    1 
ATOM   422  C CB   . ILE A 1 34 ? 10.049  23.249 -23.287 1.00 8.68  ? 1112 ILE A CB   1 
ATOM   423  C CG1  . ILE A 1 34 ? 9.031   23.515 -22.168 1.00 8.26  ? 1112 ILE A CG1  1 
ATOM   424  C CG2  . ILE A 1 34 ? 10.932  22.131 -22.846 1.00 4.50  ? 1112 ILE A CG2  1 
ATOM   425  C CD1  . ILE A 1 34 ? 8.076   22.380 -21.902 1.00 8.04  ? 1112 ILE A CD1  1 
ATOM   426  H H    . ILE A 1 34 ? 9.525   25.308 -24.783 1.00 6.42  ? 1112 ILE A H    1 
ATOM   427  H HA   . ILE A 1 34 ? 11.240  24.846 -22.741 1.00 7.31  ? 1112 ILE A HA   1 
ATOM   428  H HB   . ILE A 1 34 ? 9.609   22.998 -24.115 1.00 10.57 ? 1112 ILE A HB   1 
ATOM   429  H HG12 . ILE A 1 34 ? 9.515   23.688 -21.346 1.00 10.06 ? 1112 ILE A HG12 1 
ATOM   430  H HG13 . ILE A 1 34 ? 8.502   24.291 -22.411 1.00 10.06 ? 1112 ILE A HG13 1 
ATOM   431  H HG21 . ILE A 1 34 ? 10.385  21.355 -22.649 1.00 5.55  ? 1112 ILE A HG21 1 
ATOM   432  H HG22 . ILE A 1 34 ? 11.557  21.922 -23.558 1.00 5.55  ? 1112 ILE A HG22 1 
ATOM   433  H HG23 . ILE A 1 34 ? 11.416  22.405 -22.051 1.00 5.55  ? 1112 ILE A HG23 1 
ATOM   434  H HD11 . ILE A 1 34 ? 7.344   22.704 -21.355 1.00 9.79  ? 1112 ILE A HD11 1 
ATOM   435  H HD12 . ILE A 1 34 ? 7.736   22.049 -22.748 1.00 9.79  ? 1112 ILE A HD12 1 
ATOM   436  H HD13 . ILE A 1 34 ? 8.549   21.672 -21.436 1.00 9.79  ? 1112 ILE A HD13 1 
ATOM   437  N N    . ILE A 1 35 ? 13.176  24.183 -24.024 1.00 8.47  ? 1113 ILE A N    1 
ATOM   438  C CA   . ILE A 1 35 ? 14.320  23.653 -24.746 1.00 4.67  ? 1113 ILE A CA   1 
ATOM   439  C C    . ILE A 1 35 ? 14.350  22.148 -24.537 1.00 5.75  ? 1113 ILE A C    1 
ATOM   440  O O    . ILE A 1 35 ? 14.530  21.663 -23.410 1.00 8.99  ? 1113 ILE A O    1 
ATOM   441  C CB   . ILE A 1 35 ? 15.616  24.308 -24.261 1.00 4.89  ? 1113 ILE A CB   1 
ATOM   442  C CG1  . ILE A 1 35 ? 15.486  25.830 -24.229 1.00 10.52 ? 1113 ILE A CG1  1 
ATOM   443  C CG2  . ILE A 1 35 ? 16.796  23.810 -25.124 1.00 9.35  ? 1113 ILE A CG2  1 
ATOM   444  C CD1  . ILE A 1 35 ? 15.221  26.428 -25.615 1.00 14.04 ? 1113 ILE A CD1  1 
ATOM   445  H H    . ILE A 1 35 ? 13.364  24.436 -23.224 1.00 10.31 ? 1113 ILE A H    1 
ATOM   446  H HA   . ILE A 1 35 ? 14.223  23.828 -25.695 1.00 5.75  ? 1113 ILE A HA   1 
ATOM   447  H HB   . ILE A 1 35 ? 15.793  24.043 -23.345 1.00 6.01  ? 1113 ILE A HB   1 
ATOM   448  H HG12 . ILE A 1 35 ? 14.747  26.072 -23.650 1.00 12.77 ? 1113 ILE A HG12 1 
ATOM   449  H HG13 . ILE A 1 35 ? 16.311  26.211 -23.890 1.00 12.77 ? 1113 ILE A HG13 1 
ATOM   450  H HG21 . ILE A 1 35 ? 17.589  24.321 -24.899 1.00 11.36 ? 1113 ILE A HG21 1 
ATOM   451  H HG22 . ILE A 1 35 ? 16.946  22.869 -24.941 1.00 11.36 ? 1113 ILE A HG22 1 
ATOM   452  H HG23 . ILE A 1 35 ? 16.576  23.934 -26.061 1.00 11.36 ? 1113 ILE A HG23 1 
ATOM   453  H HD11 . ILE A 1 35 ? 15.163  27.393 -25.536 1.00 16.99 ? 1113 ILE A HD11 1 
ATOM   454  H HD12 . ILE A 1 35 ? 15.951  26.188 -26.207 1.00 16.99 ? 1113 ILE A HD12 1 
ATOM   455  H HD13 . ILE A 1 35 ? 14.386  26.072 -25.957 1.00 16.99 ? 1113 ILE A HD13 1 
ATOM   456  N N    . VAL A 1 36 ? 14.232  21.413 -25.620 1.00 5.44  ? 1114 VAL A N    1 
ATOM   457  C CA   . VAL A 1 36 ? 14.195  19.967 -25.583 1.00 4.30  ? 1114 VAL A CA   1 
ATOM   458  C C    . VAL A 1 36 ? 15.620  19.469 -25.561 1.00 8.10  ? 1114 VAL A C    1 
ATOM   459  O O    . VAL A 1 36 ? 16.394  19.749 -26.480 1.00 10.74 ? 1114 VAL A O    1 
ATOM   460  C CB   . VAL A 1 36 ? 13.422  19.405 -26.778 1.00 6.22  ? 1114 VAL A CB   1 
ATOM   461  C CG1  . VAL A 1 36 ? 13.366  17.887 -26.718 1.00 8.03  ? 1114 VAL A CG1  1 
ATOM   462  C CG2  . VAL A 1 36 ? 12.078  20.021 -26.754 1.00 10.95 ? 1114 VAL A CG2  1 
ATOM   463  H H    . VAL A 1 36 ? 14.169  21.737 -26.414 1.00 6.68  ? 1114 VAL A H    1 
ATOM   464  H HA   . VAL A 1 36 ? 13.753  19.668 -24.773 1.00 5.31  ? 1114 VAL A HA   1 
ATOM   465  H HB   . VAL A 1 36 ? 13.858  19.617 -27.618 1.00 7.61  ? 1114 VAL A HB   1 
ATOM   466  H HG11 . VAL A 1 36 ? 12.805  17.563 -27.439 1.00 9.78  ? 1114 VAL A HG11 1 
ATOM   467  H HG12 . VAL A 1 36 ? 14.264  17.534 -26.814 1.00 9.78  ? 1114 VAL A HG12 1 
ATOM   468  H HG13 . VAL A 1 36 ? 12.995  17.618 -25.863 1.00 9.78  ? 1114 VAL A HG13 1 
ATOM   469  H HG21 . VAL A 1 36 ? 11.526  19.599 -27.431 1.00 13.29 ? 1114 VAL A HG21 1 
ATOM   470  H HG22 . VAL A 1 36 ? 11.685  19.888 -25.877 1.00 13.29 ? 1114 VAL A HG22 1 
ATOM   471  H HG23 . VAL A 1 36 ? 12.162  20.969 -26.939 1.00 13.29 ? 1114 VAL A HG23 1 
ATOM   472  N N    . THR A 1 37 ? 15.965  18.714 -24.516 1.00 7.80  ? 1115 THR A N    1 
ATOM   473  C CA   . THR A 1 37 ? 17.307  18.200 -24.382 1.00 9.37  ? 1115 THR A CA   1 
ATOM   474  C C    . THR A 1 37 ? 17.343  16.686 -24.416 1.00 12.08 ? 1115 THR A C    1 
ATOM   475  O O    . THR A 1 37 ? 18.427  16.122 -24.349 1.00 9.69  ? 1115 THR A O    1 
ATOM   476  C CB   . THR A 1 37 ? 17.951  18.718 -23.092 1.00 6.67  ? 1115 THR A CB   1 
ATOM   477  O OG1  . THR A 1 37 ? 17.168  18.322 -21.944 1.00 8.96  ? 1115 THR A OG1  1 
ATOM   478  C CG2  . THR A 1 37 ? 18.070  20.218 -23.151 1.00 9.05  ? 1115 THR A CG2  1 
ATOM   479  H H    . THR A 1 37 ? 15.433  18.492 -23.878 1.00 9.50  ? 1115 THR A H    1 
ATOM   480  H HA   . THR A 1 37 ? 17.851  18.527 -25.115 1.00 11.39 ? 1115 THR A HA   1 
ATOM   481  H HB   . THR A 1 37 ? 18.840  18.341 -22.993 1.00 8.15  ? 1115 THR A HB   1 
ATOM   482  H HG1  . THR A 1 37 ? 17.167  17.485 -21.872 1.00 10.90 ? 1115 THR A HG1  1 
ATOM   483  H HG21 . THR A 1 37 ? 18.516  20.548 -22.355 1.00 11.01 ? 1115 THR A HG21 1 
ATOM   484  H HG22 . THR A 1 37 ? 18.583  20.480 -23.931 1.00 11.01 ? 1115 THR A HG22 1 
ATOM   485  H HG23 . THR A 1 37 ? 17.188  20.619 -23.206 1.00 11.01 ? 1115 THR A HG23 1 
ATOM   486  N N    . GLY A 1 38 ? 16.208  16.017 -24.554 1.00 12.58 ? 1116 GLY A N    1 
ATOM   487  C CA   . GLY A 1 38 ? 16.235  14.570 -24.543 1.00 13.25 ? 1116 GLY A CA   1 
ATOM   488  C C    . GLY A 1 38 ? 14.836  14.036 -24.746 1.00 15.59 ? 1116 GLY A C    1 
ATOM   489  O O    . GLY A 1 38 ? 13.852  14.783 -24.752 1.00 10.73 ? 1116 GLY A O    1 
ATOM   490  H H    . GLY A 1 38 ? 15.430  16.371 -24.653 1.00 15.24 ? 1116 GLY A H    1 
ATOM   491  H HA2  . GLY A 1 38 ? 16.806  14.243 -25.255 1.00 16.04 ? 1116 GLY A HA2  1 
ATOM   492  H HA3  . GLY A 1 38 ? 16.576  14.251 -23.693 1.00 16.04 ? 1116 GLY A HA3  1 
ATOM   493  N N    . GLU A 1 39 ? 14.757  12.710 -24.874 1.00 18.24 ? 1117 GLU A N    1 
ATOM   494  C CA   . GLU A 1 39 ? 13.495  12.009 -25.066 1.00 13.19 ? 1117 GLU A CA   1 
ATOM   495  C C    . GLU A 1 39 ? 13.411  10.800 -24.152 1.00 14.81 ? 1117 GLU A C    1 
ATOM   496  O O    . GLU A 1 39 ? 14.368  10.030 -24.041 1.00 18.18 ? 1117 GLU A O    1 
ATOM   497  C CB   . GLU A 1 39 ? 13.313  11.530 -26.508 1.00 15.16 ? 1117 GLU A CB   1 
ATOM   498  C CG   . GLU A 1 39 ? 13.198  12.622 -27.525 1.00 31.48 ? 1117 GLU A CG   1 
ATOM   499  C CD   . GLU A 1 39 ? 14.414  12.709 -28.443 1.00 46.72 ? 1117 GLU A CD   1 
ATOM   500  O OE1  . GLU A 1 39 ? 14.884  13.850 -28.689 1.00 42.07 ? 1117 GLU A OE1  1 
ATOM   501  O OE2  . GLU A 1 39 ? 14.890  11.644 -28.924 1.00 48.07 ? 1117 GLU A OE2  1 
ATOM   502  H H    . GLU A 1 39 ? 15.439  12.187 -24.852 1.00 22.03 ? 1117 GLU A H    1 
ATOM   503  H HA   . GLU A 1 39 ? 12.786  12.630 -24.837 1.00 15.97 ? 1117 GLU A HA   1 
ATOM   504  H HB2  . GLU A 1 39 ? 14.079  10.986 -26.750 1.00 18.34 ? 1117 GLU A HB2  1 
ATOM   505  H HB3  . GLU A 1 39 ? 12.502  11.000 -26.556 1.00 18.34 ? 1117 GLU A HB3  1 
ATOM   506  H HG2  . GLU A 1 39 ? 12.418  12.458 -28.076 1.00 37.92 ? 1117 GLU A HG2  1 
ATOM   507  H HG3  . GLU A 1 39 ? 13.108  13.472 -27.066 1.00 37.92 ? 1117 GLU A HG3  1 
ATOM   508  N N    . GLU A 1 40 ? 12.265  10.622 -23.520 1.00 13.29 ? 1118 GLU A N    1 
ATOM   509  C CA   . GLU A 1 40 ? 11.993  9.355  -22.869 1.00 12.35 ? 1118 GLU A CA   1 
ATOM   510  C C    . GLU A 1 40 ? 11.318  8.399  -23.842 1.00 10.80 ? 1118 GLU A C    1 
ATOM   511  O O    . GLU A 1 40 ? 11.772  7.275  -24.057 1.00 12.44 ? 1118 GLU A O    1 
ATOM   512  C CB   . GLU A 1 40 ? 11.111  9.577  -21.647 1.00 15.28 ? 1118 GLU A CB   1 
ATOM   513  C CG   . GLU A 1 40 ? 10.442  8.327  -21.109 1.00 19.06 ? 1118 GLU A CG   1 
ATOM   514  C CD   . GLU A 1 40 ? 9.871   8.564  -19.738 1.00 15.16 ? 1118 GLU A CD   1 
ATOM   515  O OE1  . GLU A 1 40 ? 10.669  8.821  -18.815 1.00 18.75 ? 1118 GLU A OE1  1 
ATOM   516  O OE2  . GLU A 1 40 ? 8.631   8.521  -19.583 1.00 15.67 ? 1118 GLU A OE2  1 
ATOM   517  H H    . GLU A 1 40 ? 11.639  11.208 -23.456 1.00 16.09 ? 1118 GLU A H    1 
ATOM   518  H HA   . GLU A 1 40 ? 12.822  8.958  -22.559 1.00 14.97 ? 1118 GLU A HA   1 
ATOM   519  H HB2  . GLU A 1 40 ? 11.657  9.945  -20.935 1.00 18.49 ? 1118 GLU A HB2  1 
ATOM   520  H HB3  . GLU A 1 40 ? 10.409  10.204 -21.884 1.00 18.49 ? 1118 GLU A HB3  1 
ATOM   521  H HG2  . GLU A 1 40 ? 9.720   8.067  -21.702 1.00 23.01 ? 1118 GLU A HG2  1 
ATOM   522  H HG3  . GLU A 1 40 ? 11.096  7.612  -21.050 1.00 23.01 ? 1118 GLU A HG3  1 
ATOM   523  N N    . ASP A 1 41 ? 10.256  8.840  -24.478 1.00 10.59 ? 1119 ASP A N    1 
ATOM   524  C CA   . ASP A 1 41 ? 9.645   8.050  -25.526 1.00 13.51 ? 1119 ASP A CA   1 
ATOM   525  C C    . ASP A 1 41 ? 8.836   8.987  -26.390 1.00 12.46 ? 1119 ASP A C    1 
ATOM   526  O O    . ASP A 1 41 ? 8.939   10.212 -26.271 1.00 12.67 ? 1119 ASP A O    1 
ATOM   527  C CB   . ASP A 1 41 ? 8.779   6.901  -24.978 1.00 14.70 ? 1119 ASP A CB   1 
ATOM   528  C CG   . ASP A 1 41 ? 7.548   7.371  -24.214 1.00 13.04 ? 1119 ASP A CG   1 
ATOM   529  O OD1  . ASP A 1 41 ? 7.086   8.529  -24.361 1.00 12.00 ? 1119 ASP A OD1  1 
ATOM   530  O OD2  . ASP A 1 41 ? 7.024   6.543  -23.443 1.00 16.52 ? 1119 ASP A OD2  1 
ATOM   531  H H    . ASP A 1 41 ? 9.870   9.593  -24.323 1.00 12.86 ? 1119 ASP A H    1 
ATOM   532  H HA   . ASP A 1 41 ? 10.360  7.651  -26.047 1.00 16.36 ? 1119 ASP A HA   1 
ATOM   533  H HB2  . ASP A 1 41 ? 8.476   6.357  -25.722 1.00 17.79 ? 1119 ASP A HB2  1 
ATOM   534  H HB3  . ASP A 1 41 ? 9.317   6.366  -24.373 1.00 17.79 ? 1119 ASP A HB3  1 
ATOM   535  N N    . GLN A 1 42 ? 8.020   8.398  -27.251 1.00 10.72 ? 1120 GLN A N    1 
ATOM   536  C CA   . GLN A 1 42 ? 7.272   9.190  -28.207 1.00 23.39 ? 1120 GLN A CA   1 
ATOM   537  C C    . GLN A 1 42 ? 6.297   10.125 -27.515 1.00 16.52 ? 1120 GLN A C    1 
ATOM   538  O O    . GLN A 1 42 ? 5.894   11.135 -28.108 1.00 15.40 ? 1120 GLN A O    1 
ATOM   539  C CB   . GLN A 1 42 ? 6.601   8.231  -29.194 1.00 29.29 ? 1120 GLN A CB   1 
ATOM   540  C CG   . GLN A 1 42 ? 5.311   8.713  -29.814 1.00 41.37 ? 1120 GLN A CG   1 
ATOM   541  C CD   . GLN A 1 42 ? 4.425   7.537  -30.279 1.00 47.69 ? 1120 GLN A CD   1 
ATOM   542  O OE1  . GLN A 1 42 ? 4.920   6.591  -30.891 1.00 47.69 ? 1120 GLN A OE1  1 
ATOM   543  N NE2  . GLN A 1 42 ? 3.114   7.602  -29.980 1.00 43.48 ? 1120 GLN A NE2  1 
ATOM   544  H H    . GLN A 1 42 ? 7.884   7.550  -27.301 1.00 13.01 ? 1120 GLN A H    1 
ATOM   545  H HA   . GLN A 1 42 ? 7.857   9.768  -28.721 1.00 28.21 ? 1120 GLN A HA   1 
ATOM   546  H HB2  . GLN A 1 42 ? 7.221   8.061  -29.920 1.00 35.30 ? 1120 GLN A HB2  1 
ATOM   547  H HB3  . GLN A 1 42 ? 6.402   7.405  -28.726 1.00 35.30 ? 1120 GLN A HB3  1 
ATOM   548  H HG2  . GLN A 1 42 ? 4.814   9.228  -29.159 1.00 49.79 ? 1120 GLN A HG2  1 
ATOM   549  H HG3  . GLN A 1 42 ? 5.513   9.265  -30.585 1.00 49.79 ? 1120 GLN A HG3  1 
ATOM   550  H HE21 . GLN A 1 42 ? 2.804   8.278  -29.549 1.00 52.32 ? 1120 GLN A HE21 1 
ATOM   551  H HE22 . GLN A 1 42 ? 2.586   6.967  -30.222 1.00 52.32 ? 1120 GLN A HE22 1 
ATOM   552  N N    . GLU A 1 43 ? 5.876   9.808  -26.296 1.00 13.55 ? 1121 GLU A N    1 
ATOM   553  C CA   . GLU A 1 43 ? 4.911   10.665 -25.648 1.00 11.83 ? 1121 GLU A CA   1 
ATOM   554  C C    . GLU A 1 43 ? 5.521   11.584 -24.607 1.00 9.04  ? 1121 GLU A C    1 
ATOM   555  O O    . GLU A 1 43 ? 4.846   12.529 -24.169 1.00 9.97  ? 1121 GLU A O    1 
ATOM   556  C CB   . GLU A 1 43 ? 3.809   9.823  -25.011 1.00 11.36 ? 1121 GLU A CB   1 
ATOM   557  C CG   . GLU A 1 43 ? 2.906   9.117  -26.009 1.00 19.34 ? 1121 GLU A CG   1 
ATOM   558  C CD   . GLU A 1 43 ? 2.189   10.066 -26.966 1.00 22.01 ? 1121 GLU A CD   1 
ATOM   559  O OE1  . GLU A 1 43 ? 1.977   11.251 -26.616 1.00 21.22 ? 1121 GLU A OE1  1 
ATOM   560  O OE2  . GLU A 1 43 ? 1.843   9.626  -28.082 1.00 30.89 ? 1121 GLU A OE2  1 
ATOM   561  H H    . GLU A 1 43 ? 6.131   9.122  -25.844 1.00 16.40 ? 1121 GLU A H    1 
ATOM   562  H HA   . GLU A 1 43 ? 4.500   11.231 -26.320 1.00 14.34 ? 1121 GLU A HA   1 
ATOM   563  H HB2  . GLU A 1 43 ? 4.220   9.143  -24.455 1.00 13.78 ? 1121 GLU A HB2  1 
ATOM   564  H HB3  . GLU A 1 43 ? 3.251   10.402 -24.468 1.00 13.78 ? 1121 GLU A HB3  1 
ATOM   565  H HG2  . GLU A 1 43 ? 3.443   8.510  -26.541 1.00 23.35 ? 1121 GLU A HG2  1 
ATOM   566  H HG3  . GLU A 1 43 ? 2.229   8.621  -25.522 1.00 23.35 ? 1121 GLU A HG3  1 
ATOM   567  N N    . TRP A 1 44 ? 6.764   11.355 -24.216 1.00 10.19 ? 1122 TRP A N    1 
ATOM   568  C CA   . TRP A 1 44 ? 7.403   12.093 -23.140 1.00 6.96  ? 1122 TRP A CA   1 
ATOM   569  C C    . TRP A 1 44 ? 8.801   12.506 -23.594 1.00 7.47  ? 1122 TRP A C    1 
ATOM   570  O O    . TRP A 1 44 ? 9.616   11.660 -23.953 1.00 8.01  ? 1122 TRP A O    1 
ATOM   571  C CB   . TRP A 1 44 ? 7.451   11.222 -21.885 1.00 7.87  ? 1122 TRP A CB   1 
ATOM   572  C CG   . TRP A 1 44 ? 6.084   11.039 -21.227 1.00 6.25  ? 1122 TRP A CG   1 
ATOM   573  C CD1  . TRP A 1 44 ? 5.186   10.044 -21.461 1.00 7.63  ? 1122 TRP A CD1  1 
ATOM   574  C CD2  . TRP A 1 44 ? 5.482   11.902 -20.281 1.00 6.58  ? 1122 TRP A CD2  1 
ATOM   575  N NE1  . TRP A 1 44 ? 4.078   10.215 -20.695 1.00 10.59 ? 1122 TRP A NE1  1 
ATOM   576  C CE2  . TRP A 1 44 ? 4.216   11.370 -19.976 1.00 9.71  ? 1122 TRP A CE2  1 
ATOM   577  C CE3  . TRP A 1 44 ? 5.885   13.083 -19.656 1.00 8.99  ? 1122 TRP A CE3  1 
ATOM   578  C CZ2  . TRP A 1 44 ? 3.357   11.971 -19.075 1.00 6.55  ? 1122 TRP A CZ2  1 
ATOM   579  C CZ3  . TRP A 1 44 ? 5.047   13.658 -18.735 1.00 8.50  ? 1122 TRP A CZ3  1 
ATOM   580  C CH2  . TRP A 1 44 ? 3.788   13.110 -18.465 1.00 8.35  ? 1122 TRP A CH2  1 
ATOM   581  H H    . TRP A 1 44 ? 7.273   10.758 -24.570 1.00 12.38 ? 1122 TRP A H    1 
ATOM   582  H HA   . TRP A 1 44 ? 6.916   12.907 -22.938 1.00 8.50  ? 1122 TRP A HA   1 
ATOM   583  H HB2  . TRP A 1 44 ? 7.787   10.345 -22.124 1.00 9.60  ? 1122 TRP A HB2  1 
ATOM   584  H HB3  . TRP A 1 44 ? 8.041   11.638 -21.236 1.00 9.60  ? 1122 TRP A HB3  1 
ATOM   585  H HD1  . TRP A 1 44 ? 5.313   9.345  -22.062 1.00 9.30  ? 1122 TRP A HD1  1 
ATOM   586  H HE1  . TRP A 1 44 ? 3.401   9.685  -20.666 1.00 12.85 ? 1122 TRP A HE1  1 
ATOM   587  H HE3  . TRP A 1 44 ? 6.705   13.473 -19.860 1.00 10.93 ? 1122 TRP A HE3  1 
ATOM   588  H HZ2  . TRP A 1 44 ? 2.518   11.612 -18.892 1.00 8.00  ? 1122 TRP A HZ2  1 
ATOM   589  H HZ3  . TRP A 1 44 ? 5.320   14.423 -18.282 1.00 10.34 ? 1122 TRP A HZ3  1 
ATOM   590  H HH2  . TRP A 1 44 ? 3.230   13.535 -17.854 1.00 10.17 ? 1122 TRP A HH2  1 
ATOM   591  N N    . TRP A 1 45 ? 9.068   13.793 -23.584 1.00 5.38  ? 1123 TRP A N    1 
ATOM   592  C CA   . TRP A 1 45 ? 10.379  14.329 -23.866 1.00 8.69  ? 1123 TRP A CA   1 
ATOM   593  C C    . TRP A 1 45 ? 10.915  14.942 -22.589 1.00 7.72  ? 1123 TRP A C    1 
ATOM   594  O O    . TRP A 1 45 ? 10.226  14.985 -21.578 1.00 8.14  ? 1123 TRP A O    1 
ATOM   595  C CB   . TRP A 1 45 ? 10.325  15.353 -25.002 1.00 6.77  ? 1123 TRP A CB   1 
ATOM   596  C CG   . TRP A 1 45 ? 10.075  14.722 -26.332 1.00 10.02 ? 1123 TRP A CG   1 
ATOM   597  C CD1  . TRP A 1 45 ? 10.069  13.385 -26.632 1.00 12.12 ? 1123 TRP A CD1  1 
ATOM   598  C CD2  . TRP A 1 45 ? 9.816   15.409 -27.553 1.00 10.79 ? 1123 TRP A CD2  1 
ATOM   599  N NE1  . TRP A 1 45 ? 9.794   13.205 -27.970 1.00 10.22 ? 1123 TRP A NE1  1 
ATOM   600  C CE2  . TRP A 1 45 ? 9.657   14.435 -28.559 1.00 10.32 ? 1123 TRP A CE2  1 
ATOM   601  C CE3  . TRP A 1 45 ? 9.695   16.757 -27.895 1.00 10.63 ? 1123 TRP A CE3  1 
ATOM   602  C CZ2  . TRP A 1 45 ? 9.394   14.771 -29.875 1.00 12.00 ? 1123 TRP A CZ2  1 
ATOM   603  C CZ3  . TRP A 1 45 ? 9.414   17.079 -29.208 1.00 12.01 ? 1123 TRP A CZ3  1 
ATOM   604  C CH2  . TRP A 1 45 ? 9.269   16.096 -30.168 1.00 9.94  ? 1123 TRP A CH2  1 
ATOM   605  H H    . TRP A 1 45 ? 8.482   14.399 -23.410 1.00 6.61  ? 1123 TRP A H    1 
ATOM   606  H HA   . TRP A 1 45 ? 10.972  13.619 -24.157 1.00 10.57 ? 1123 TRP A HA   1 
ATOM   607  H HB2  . TRP A 1 45 ? 9.606   15.981 -24.828 1.00 8.27  ? 1123 TRP A HB2  1 
ATOM   608  H HB3  . TRP A 1 45 ? 11.172  15.822 -25.046 1.00 8.27  ? 1123 TRP A HB3  1 
ATOM   609  H HD1  . TRP A 1 45 ? 10.227  12.701 -26.023 1.00 14.69 ? 1123 TRP A HD1  1 
ATOM   610  H HE1  . TRP A 1 45 ? 9.720   12.446 -28.369 1.00 12.41 ? 1123 TRP A HE1  1 
ATOM   611  H HE3  . TRP A 1 45 ? 9.800   17.423 -27.254 1.00 12.90 ? 1123 TRP A HE3  1 
ATOM   612  H HZ2  . TRP A 1 45 ? 9.305   14.120 -30.533 1.00 14.55 ? 1123 TRP A HZ2  1 
ATOM   613  H HZ3  . TRP A 1 45 ? 9.321   17.972 -29.451 1.00 14.55 ? 1123 TRP A HZ3  1 
ATOM   614  H HH2  . TRP A 1 45 ? 9.080   16.346 -31.043 1.00 12.07 ? 1123 TRP A HH2  1 
ATOM   615  N N    . ILE A 1 46 ? 12.167  15.399 -22.644 1.00 8.86  ? 1124 ILE A N    1 
ATOM   616  C CA   . ILE A 1 46 ? 12.863  15.981 -21.503 1.00 6.33  ? 1124 ILE A CA   1 
ATOM   617  C C    . ILE A 1 46 ? 13.392  17.337 -21.912 1.00 4.49  ? 1124 ILE A C    1 
ATOM   618  O O    . ILE A 1 46 ? 13.858  17.512 -23.042 1.00 7.07  ? 1124 ILE A O    1 
ATOM   619  C CB   . ILE A 1 46 ? 14.001  15.058 -21.018 1.00 9.44  ? 1124 ILE A CB   1 
ATOM   620  C CG1  . ILE A 1 46 ? 13.510  13.606 -21.010 1.00 11.57 ? 1124 ILE A CG1  1 
ATOM   621  C CG2  . ILE A 1 46 ? 14.482  15.515 -19.654 1.00 11.31 ? 1124 ILE A CG2  1 
ATOM   622  C CD1  . ILE A 1 46 ? 14.567  12.592 -20.664 1.00 15.06 ? 1124 ILE A CD1  1 
ATOM   623  H H    . ILE A 1 46 ? 12.648  15.380 -23.357 1.00 10.77 ? 1124 ILE A H    1 
ATOM   624  H HA   . ILE A 1 46 ? 12.246  16.110 -20.766 1.00 7.74  ? 1124 ILE A HA   1 
ATOM   625  H HB   . ILE A 1 46 ? 14.757  15.109 -21.624 1.00 11.48 ? 1124 ILE A HB   1 
ATOM   626  H HG12 . ILE A 1 46 ? 12.800  13.524 -20.356 1.00 14.03 ? 1124 ILE A HG12 1 
ATOM   627  H HG13 . ILE A 1 46 ? 13.174  13.389 -21.894 1.00 14.03 ? 1124 ILE A HG13 1 
ATOM   628  H HG21 . ILE A 1 46 ? 15.251  14.983 -19.396 1.00 13.71 ? 1124 ILE A HG21 1 
ATOM   629  H HG22 . ILE A 1 46 ? 14.730  16.451 -19.704 1.00 13.71 ? 1124 ILE A HG22 1 
ATOM   630  H HG23 . ILE A 1 46 ? 13.766  15.395 -19.011 1.00 13.71 ? 1124 ILE A HG23 1 
ATOM   631  H HD11 . ILE A 1 46 ? 14.199  11.702 -20.776 1.00 18.22 ? 1124 ILE A HD11 1 
ATOM   632  H HD12 . ILE A 1 46 ? 15.326  12.713 -21.255 1.00 18.22 ? 1124 ILE A HD12 1 
ATOM   633  H HD13 . ILE A 1 46 ? 14.840  12.723 -19.743 1.00 18.22 ? 1124 ILE A HD13 1 
ATOM   634  N N    . GLY A 1 47 ? 13.300  18.303 -21.013 1.00 2.76  ? 1125 GLY A N    1 
ATOM   635  C CA   . GLY A 1 47 ? 13.773  19.616 -21.367 1.00 2.68  ? 1125 GLY A CA   1 
ATOM   636  C C    . GLY A 1 47 ? 13.699  20.555 -20.200 1.00 2.07  ? 1125 GLY A C    1 
ATOM   637  O O    . GLY A 1 47 ? 13.473  20.150 -19.061 1.00 8.90  ? 1125 GLY A O    1 
ATOM   638  H H    . GLY A 1 47 ? 12.977  18.222 -20.220 1.00 3.46  ? 1125 GLY A H    1 
ATOM   639  H HA2  . GLY A 1 47 ? 14.695  19.561 -21.662 1.00 3.36  ? 1125 GLY A HA2  1 
ATOM   640  H HA3  . GLY A 1 47 ? 13.231  19.975 -22.087 1.00 3.36  ? 1125 GLY A HA3  1 
ATOM   641  N N    . HIS A 1 48 ? 13.852  21.836 -20.511 1.00 2.53  ? 1126 HIS A N    1 
ATOM   642  C CA   . HIS A 1 48 ? 13.817  22.863 -19.500 1.00 4.74  ? 1126 HIS A CA   1 
ATOM   643  C C    . HIS A 1 48 ? 13.270  24.138 -20.067 1.00 5.34  ? 1126 HIS A C    1 
ATOM   644  O O    . HIS A 1 48 ? 13.218  24.328 -21.278 1.00 10.40 ? 1126 HIS A O    1 
ATOM   645  C CB   . HIS A 1 48 ? 15.186  23.156 -18.920 1.00 8.82  ? 1126 HIS A CB   1 
ATOM   646  C CG   . HIS A 1 48 ? 16.217  23.552 -19.925 1.00 5.31  ? 1126 HIS A CG   1 
ATOM   647  N ND1  . HIS A 1 48 ? 17.050  22.638 -20.522 1.00 7.45  ? 1126 HIS A ND1  1 
ATOM   648  C CD2  . HIS A 1 48 ? 16.562  24.766 -20.427 1.00 7.96  ? 1126 HIS A CD2  1 
ATOM   649  C CE1  . HIS A 1 48 ? 17.898  23.273 -21.325 1.00 9.31  ? 1126 HIS A CE1  1 
ATOM   650  N NE2  . HIS A 1 48 ? 17.627  24.566 -21.276 1.00 8.46  ? 1126 HIS A NE2  1 
ATOM   651  H H    . HIS A 1 48 ? 13.978  22.130 -21.309 1.00 3.19  ? 1126 HIS A H    1 
ATOM   652  H HA   . HIS A 1 48 ? 13.227  22.545 -18.798 1.00 5.84  ? 1126 HIS A HA   1 
ATOM   653  H HB2  . HIS A 1 48 ? 15.102  23.884 -18.285 1.00 10.73 ? 1126 HIS A HB2  1 
ATOM   654  H HB3  . HIS A 1 48 ? 15.507  22.359 -18.470 1.00 10.73 ? 1126 HIS A HB3  1 
ATOM   655  H HD2  . HIS A 1 48 ? 16.155  25.579 -20.233 1.00 9.70  ? 1126 HIS A HD2  1 
ATOM   656  H HE1  . HIS A 1 48 ? 18.567  22.875 -21.834 1.00 11.32 ? 1126 HIS A HE1  1 
ATOM   657  H HE2  . HIS A 1 48 ? 18.047  25.182 -21.704 1.00 10.30 ? 1126 HIS A HE2  1 
ATOM   658  N N    . ILE A 1 49 ? 12.842  25.016 -19.166 1.00 10.42 ? 1127 ILE A N    1 
ATOM   659  C CA   . ILE A 1 49 ? 12.209  26.268 -19.577 1.00 9.84  ? 1127 ILE A CA   1 
ATOM   660  C C    . ILE A 1 49 ? 13.258  27.211 -20.152 1.00 9.74  ? 1127 ILE A C    1 
ATOM   661  O O    . ILE A 1 49 ? 14.293  27.472 -19.531 1.00 8.13  ? 1127 ILE A O    1 
ATOM   662  C CB   . ILE A 1 49 ? 11.469  26.930 -18.405 1.00 7.83  ? 1127 ILE A CB   1 
ATOM   663  C CG1  . ILE A 1 49 ? 10.356  26.019 -17.911 1.00 10.67 ? 1127 ILE A CG1  1 
ATOM   664  C CG2  . ILE A 1 49 ? 10.797  28.255 -18.851 1.00 8.67  ? 1127 ILE A CG2  1 
ATOM   665  C CD1  . ILE A 1 49 ? 9.082   26.043 -18.830 1.00 10.89 ? 1127 ILE A CD1  1 
ATOM   666  H H    . ILE A 1 49 ? 12.904  24.913 -18.314 1.00 12.65 ? 1127 ILE A H    1 
ATOM   667  H HA   . ILE A 1 49 ? 11.561  26.063 -20.269 1.00 11.95 ? 1127 ILE A HA   1 
ATOM   668  H HB   . ILE A 1 49 ? 12.126  27.098 -17.712 1.00 9.55  ? 1127 ILE A HB   1 
ATOM   669  H HG12 . ILE A 1 49 ? 10.687  25.107 -17.882 1.00 12.95 ? 1127 ILE A HG12 1 
ATOM   670  H HG13 . ILE A 1 49 ? 10.089  26.302 -17.023 1.00 12.95 ? 1127 ILE A HG13 1 
ATOM   671  H HG21 . ILE A 1 49 ? 10.129  28.507 -18.194 1.00 10.56 ? 1127 ILE A HG21 1 
ATOM   672  H HG22 . ILE A 1 49 ? 11.474  28.947 -18.916 1.00 10.56 ? 1127 ILE A HG22 1 
ATOM   673  H HG23 . ILE A 1 49 ? 10.377  28.121 -19.715 1.00 10.56 ? 1127 ILE A HG23 1 
ATOM   674  H HD11 . ILE A 1 49 ? 8.560   25.242 -18.668 1.00 13.21 ? 1127 ILE A HD11 1 
ATOM   675  H HD12 . ILE A 1 49 ? 8.555   26.829 -18.619 1.00 13.21 ? 1127 ILE A HD12 1 
ATOM   676  H HD13 . ILE A 1 49 ? 9.363   26.072 -19.758 1.00 13.21 ? 1127 ILE A HD13 1 
ATOM   677  N N    . GLU A 1 50 ? 12.980  27.739 -21.341 1.00 9.20  ? 1128 GLU A N    1 
ATOM   678  C CA   . GLU A 1 50 ? 13.831  28.744 -21.925 1.00 10.91 ? 1128 GLU A CA   1 
ATOM   679  C C    . GLU A 1 50 ? 13.791  29.997 -21.064 1.00 10.98 ? 1128 GLU A C    1 
ATOM   680  O O    . GLU A 1 50 ? 12.720  30.524 -20.749 1.00 12.96 ? 1128 GLU A O    1 
ATOM   681  C CB   . GLU A 1 50 ? 13.384  29.066 -23.341 1.00 13.15 ? 1128 GLU A CB   1 
ATOM   682  C CG   . GLU A 1 50 ? 14.234  30.119 -23.975 1.00 13.31 ? 1128 GLU A CG   1 
ATOM   683  C CD   . GLU A 1 50 ? 13.691  30.520 -25.337 1.00 16.59 ? 1128 GLU A CD   1 
ATOM   684  O OE1  . GLU A 1 50 ? 12.610  31.138 -25.381 1.00 14.53 ? 1128 GLU A OE1  1 
ATOM   685  O OE2  . GLU A 1 50 ? 14.321  30.164 -26.348 1.00 20.68 ? 1128 GLU A OE2  1 
ATOM   686  H H    . GLU A 1 50 ? 12.301  27.526 -21.823 1.00 11.18 ? 1128 GLU A H    1 
ATOM   687  H HA   . GLU A 1 50 ? 14.742  28.415 -21.972 1.00 13.24 ? 1128 GLU A HA   1 
ATOM   688  H HB2  . GLU A 1 50 ? 13.441  28.264 -23.883 1.00 15.93 ? 1128 GLU A HB2  1 
ATOM   689  H HB3  . GLU A 1 50 ? 12.469  29.388 -23.320 1.00 15.93 ? 1128 GLU A HB3  1 
ATOM   690  H HG2  . GLU A 1 50 ? 14.249  30.906 -23.407 1.00 16.11 ? 1128 GLU A HG2  1 
ATOM   691  H HG3  . GLU A 1 50 ? 15.135  29.778 -24.092 1.00 16.11 ? 1128 GLU A HG3  1 
ATOM   692  N N    . GLY A 1 51 ? 14.974  30.461 -20.666 1.00 10.89 ? 1129 GLY A N    1 
ATOM   693  C CA   . GLY A 1 51 ? 15.094  31.567 -19.755 1.00 14.20 ? 1129 GLY A CA   1 
ATOM   694  C C    . GLY A 1 51 ? 15.072  31.178 -18.291 1.00 11.34 ? 1129 GLY A C    1 
ATOM   695  O O    . GLY A 1 51 ? 15.424  31.996 -17.455 1.00 12.92 ? 1129 GLY A O    1 
ATOM   696  H H    . GLY A 1 51 ? 15.729  30.138 -20.921 1.00 13.22 ? 1129 GLY A H    1 
ATOM   697  H HA2  . GLY A 1 51 ? 15.931  32.025 -19.929 1.00 17.19 ? 1129 GLY A HA2  1 
ATOM   698  H HA3  . GLY A 1 51 ? 14.359  32.181 -19.911 1.00 17.19 ? 1129 GLY A HA3  1 
ATOM   699  N N    . GLN A 1 52 ? 14.643  29.965 -17.953 1.00 11.89 ? 1130 GLN A N    1 
ATOM   700  C CA   . GLN A 1 52 ? 14.604  29.502 -16.557 1.00 13.57 ? 1130 GLN A CA   1 
ATOM   701  C C    . GLN A 1 52 ? 15.063  28.049 -16.510 1.00 9.29  ? 1130 GLN A C    1 
ATOM   702  O O    . GLN A 1 52 ? 14.282  27.139 -16.200 1.00 9.23  ? 1130 GLN A O    1 
ATOM   703  C CB   . GLN A 1 52 ? 13.195  29.639 -15.963 1.00 13.80 ? 1130 GLN A CB   1 
ATOM   704  C CG   . GLN A 1 52 ? 12.599  31.028 -15.977 1.00 15.08 ? 1130 GLN A CG   1 
ATOM   705  C CD   . GLN A 1 52 ? 11.093  31.008 -15.686 1.00 19.13 ? 1130 GLN A CD   1 
ATOM   706  O OE1  . GLN A 1 52 ? 10.675  30.479 -14.657 1.00 24.00 ? 1130 GLN A OE1  1 
ATOM   707  N NE2  . GLN A 1 52 ? 10.282  31.621 -16.571 1.00 23.68 ? 1130 GLN A NE2  1 
ATOM   708  H H    . GLN A 1 52 ? 14.365  29.380 -18.518 1.00 14.42 ? 1130 GLN A H    1 
ATOM   709  H HA   . GLN A 1 52 ? 15.214  30.045 -16.032 1.00 16.43 ? 1130 GLN A HA   1 
ATOM   710  H HB2  . GLN A 1 52 ? 12.597  29.066 -16.468 1.00 16.71 ? 1130 GLN A HB2  1 
ATOM   711  H HB3  . GLN A 1 52 ? 13.228  29.351 -15.037 1.00 16.71 ? 1130 GLN A HB3  1 
ATOM   712  H HG2  . GLN A 1 52 ? 13.032  31.568 -15.297 1.00 18.24 ? 1130 GLN A HG2  1 
ATOM   713  H HG3  . GLN A 1 52 ? 12.734  31.425 -16.851 1.00 18.24 ? 1130 GLN A HG3  1 
ATOM   714  H HE21 . GLN A 1 52 ? 10.614  32.003 -17.266 1.00 28.56 ? 1130 GLN A HE21 1 
ATOM   715  H HE22 . GLN A 1 52 ? 9.432   31.629 -16.441 1.00 28.56 ? 1130 GLN A HE22 1 
ATOM   716  N N    . PRO A 1 53 ? 16.344  27.802 -16.811 1.00 11.82 ? 1131 PRO A N    1 
ATOM   717  C CA   . PRO A 1 53 ? 16.806  26.419 -17.023 1.00 10.33 ? 1131 PRO A CA   1 
ATOM   718  C C    . PRO A 1 53 ? 16.725  25.564 -15.782 1.00 12.65 ? 1131 PRO A C    1 
ATOM   719  O O    . PRO A 1 53 ? 16.815  24.326 -15.873 1.00 8.42  ? 1131 PRO A O    1 
ATOM   720  C CB   . PRO A 1 53 ? 18.271  26.587 -17.470 1.00 11.34 ? 1131 PRO A CB   1 
ATOM   721  C CG   . PRO A 1 53 ? 18.545  28.056 -17.548 1.00 12.47 ? 1131 PRO A CG   1 
ATOM   722  C CD   . PRO A 1 53 ? 17.456  28.763 -16.792 1.00 14.18 ? 1131 PRO A CD   1 
ATOM   723  H HA   . PRO A 1 53 ? 16.294  26.013 -17.739 1.00 12.54 ? 1131 PRO A HA   1 
ATOM   724  H HB2  . PRO A 1 53 ? 18.855  26.167 -16.820 1.00 13.76 ? 1131 PRO A HB2  1 
ATOM   725  H HB3  . PRO A 1 53 ? 18.390  26.173 -18.340 1.00 13.76 ? 1131 PRO A HB3  1 
ATOM   726  H HG2  . PRO A 1 53 ? 19.409  28.242 -17.148 1.00 15.11 ? 1131 PRO A HG2  1 
ATOM   727  H HG3  . PRO A 1 53 ? 18.544  28.333 -18.478 1.00 15.11 ? 1131 PRO A HG3  1 
ATOM   728  H HD2  . PRO A 1 53 ? 17.734  28.950 -15.881 1.00 17.16 ? 1131 PRO A HD2  1 
ATOM   729  H HD3  . PRO A 1 53 ? 17.207  29.588 -17.238 1.00 17.16 ? 1131 PRO A HD3  1 
ATOM   730  N N    . GLU A 1 54 ? 16.585  26.188 -14.620 1.00 7.48  ? 1132 GLU A N    1 
ATOM   731  C CA   . GLU A 1 54 ? 16.454  25.406 -13.412 1.00 15.15 ? 1132 GLU A CA   1 
ATOM   732  C C    . GLU A 1 54 ? 15.109  24.701 -13.364 1.00 12.65 ? 1132 GLU A C    1 
ATOM   733  O O    . GLU A 1 54 ? 14.977  23.683 -12.695 1.00 12.16 ? 1132 GLU A O    1 
ATOM   734  C CB   . GLU A 1 54 ? 16.596  26.328 -12.195 1.00 15.70 ? 1132 GLU A CB   1 
ATOM   735  C CG   . GLU A 1 54 ? 15.371  27.249 -12.010 1.00 18.95 ? 1132 GLU A CG   1 
ATOM   736  C CD   . GLU A 1 54 ? 15.433  28.579 -12.794 1.00 30.32 ? 1132 GLU A CD   1 
ATOM   737  O OE1  . GLU A 1 54 ? 16.363  28.808 -13.629 1.00 15.03 ? 1132 GLU A OE1  1 
ATOM   738  O OE2  . GLU A 1 54 ? 14.496  29.404 -12.599 1.00 31.53 ? 1132 GLU A OE2  1 
ATOM   739  H H    . GLU A 1 54 ? 16.564  27.041 -14.512 1.00 9.13  ? 1132 GLU A H    1 
ATOM   740  H HA   . GLU A 1 54 ? 17.157  24.739 -13.371 1.00 18.32 ? 1132 GLU A HA   1 
ATOM   741  H HB2  . GLU A 1 54 ? 16.690  25.787 -11.395 1.00 18.98 ? 1132 GLU A HB2  1 
ATOM   742  H HB3  . GLU A 1 54 ? 17.380  26.888 -12.310 1.00 18.98 ? 1132 GLU A HB3  1 
ATOM   743  H HG2  . GLU A 1 54 ? 14.580  26.772 -12.307 1.00 22.88 ? 1132 GLU A HG2  1 
ATOM   744  H HG3  . GLU A 1 54 ? 15.291  27.470 -11.068 1.00 22.88 ? 1132 GLU A HG3  1 
ATOM   745  N N    . ARG A 1 55 ? 14.135  25.166 -14.132 1.00 11.59 ? 1133 ARG A N    1 
ATOM   746  C CA   . ARG A 1 55 ? 12.862  24.476 -14.256 1.00 6.50  ? 1133 ARG A CA   1 
ATOM   747  C C    . ARG A 1 55 ? 12.964  23.449 -15.373 1.00 6.48  ? 1133 ARG A C    1 
ATOM   748  O O    . ARG A 1 55 ? 12.981  23.812 -16.559 1.00 7.26  ? 1133 ARG A O    1 
ATOM   749  C CB   . ARG A 1 55 ? 11.736  25.470 -14.509 1.00 9.17  ? 1133 ARG A CB   1 
ATOM   750  C CG   . ARG A 1 55 ? 11.471  26.408 -13.364 1.00 11.12 ? 1133 ARG A CG   1 
ATOM   751  C CD   . ARG A 1 55 ? 10.499  27.482 -13.798 1.00 14.65 ? 1133 ARG A CD   1 
ATOM   752  N NE   . ARG A 1 55 ? 9.251   26.866 -14.235 1.00 9.51  ? 1133 ARG A NE   1 
ATOM   753  C CZ   . ARG A 1 55 ? 8.447   27.388 -15.151 1.00 7.43  ? 1133 ARG A CZ   1 
ATOM   754  N NH1  . ARG A 1 55 ? 8.679   28.565 -15.677 1.00 10.60 ? 1133 ARG A NH1  1 
ATOM   755  N NH2  . ARG A 1 55 ? 7.397   26.697 -15.564 1.00 8.52  ? 1133 ARG A NH2  1 
ATOM   756  H H    . ARG A 1 55 ? 14.189  25.888 -14.597 1.00 14.06 ? 1133 ARG A H    1 
ATOM   757  H HA   . ARG A 1 55 ? 12.668  24.005 -13.430 1.00 7.95  ? 1133 ARG A HA   1 
ATOM   758  H HB2  . ARG A 1 55 ? 11.966  26.007 -15.283 1.00 11.15 ? 1133 ARG A HB2  1 
ATOM   759  H HB3  . ARG A 1 55 ? 10.919  24.975 -14.679 1.00 11.15 ? 1133 ARG A HB3  1 
ATOM   760  H HG2  . ARG A 1 55 ? 11.085  25.919 -12.621 1.00 13.49 ? 1133 ARG A HG2  1 
ATOM   761  H HG3  . ARG A 1 55 ? 12.300  26.831 -13.088 1.00 13.49 ? 1133 ARG A HG3  1 
ATOM   762  H HD2  . ARG A 1 55 ? 10.311  28.074 -13.054 1.00 17.73 ? 1133 ARG A HD2  1 
ATOM   763  H HD3  . ARG A 1 55 ? 10.874  27.986 -14.537 1.00 17.73 ? 1133 ARG A HD3  1 
ATOM   764  H HE   . ARG A 1 55 ? 9.022   26.119 -13.877 1.00 11.56 ? 1133 ARG A HE   1 
ATOM   765  H HH11 . ARG A 1 55 ? 9.366   29.019 -15.429 1.00 12.87 ? 1133 ARG A HH11 1 
ATOM   766  H HH12 . ARG A 1 55 ? 8.144   28.885 -16.270 1.00 12.87 ? 1133 ARG A HH12 1 
ATOM   767  H HH21 . ARG A 1 55 ? 7.240   25.917 -15.239 1.00 10.37 ? 1133 ARG A HH21 1 
ATOM   768  H HH22 . ARG A 1 55 ? 6.870   27.029 -16.158 1.00 10.37 ? 1133 ARG A HH22 1 
ATOM   769  N N    . LYS A 1 56 ? 13.040  22.166 -15.008 1.00 4.98  ? 1134 LYS A N    1 
ATOM   770  C CA   . LYS A 1 56 ? 13.367  21.129 -15.976 1.00 5.53  ? 1134 LYS A CA   1 
ATOM   771  C C    . LYS A 1 56 ? 12.715  19.817 -15.608 1.00 4.80  ? 1134 LYS A C    1 
ATOM   772  O O    . LYS A 1 56 ? 12.313  19.600 -14.466 1.00 11.73 ? 1134 LYS A O    1 
ATOM   773  C CB   . LYS A 1 56 ? 14.884  20.913 -16.065 1.00 5.03  ? 1134 LYS A CB   1 
ATOM   774  C CG   . LYS A 1 56 ? 15.412  20.722 -14.679 1.00 9.14  ? 1134 LYS A CG   1 
ATOM   775  C CD   . LYS A 1 56 ? 16.658  19.915 -14.613 1.00 24.38 ? 1134 LYS A CD   1 
ATOM   776  C CE   . LYS A 1 56 ? 17.872  20.767 -14.670 1.00 18.25 ? 1134 LYS A CE   1 
ATOM   777  N NZ   . LYS A 1 56 ? 19.062  19.858 -14.557 1.00 28.76 ? 1134 LYS A NZ   1 
ATOM   778  H H    . LYS A 1 56 ? 12.907  21.878 -14.209 1.00 6.12  ? 1134 LYS A H    1 
ATOM   779  H HA   . LYS A 1 56 ? 13.012  21.409 -16.834 1.00 6.78  ? 1134 LYS A HA   1 
ATOM   780  H HB2  . LYS A 1 56 ? 15.077  20.121 -16.592 1.00 6.18  ? 1134 LYS A HB2  1 
ATOM   781  H HB3  . LYS A 1 56 ? 15.308  21.688 -16.465 1.00 6.18  ? 1134 LYS A HB3  1 
ATOM   782  H HG2  . LYS A 1 56 ? 15.604  21.593 -14.296 1.00 11.12 ? 1134 LYS A HG2  1 
ATOM   783  H HG3  . LYS A 1 56 ? 14.739  20.268 -14.148 1.00 11.12 ? 1134 LYS A HG3  1 
ATOM   784  H HD2  . LYS A 1 56 ? 16.675  19.419 -13.780 1.00 29.40 ? 1134 LYS A HD2  1 
ATOM   785  H HD3  . LYS A 1 56 ? 16.683  19.302 -15.365 1.00 29.40 ? 1134 LYS A HD3  1 
ATOM   786  H HE2  . LYS A 1 56 ? 17.910  21.244 -15.514 1.00 22.05 ? 1134 LYS A HE2  1 
ATOM   787  H HE3  . LYS A 1 56 ? 17.876  21.397 -13.932 1.00 22.05 ? 1134 LYS A HE3  1 
ATOM   788  H HZ1  . LYS A 1 56 ? 19.092  19.308 -15.256 1.00 34.66 ? 1134 LYS A HZ1  1 
ATOM   789  H HZ2  . LYS A 1 56 ? 19.811  20.338 -14.535 1.00 34.66 ? 1134 LYS A HZ2  1 
ATOM   790  H HZ3  . LYS A 1 56 ? 19.006  19.375 -13.812 1.00 34.66 ? 1134 LYS A HZ3  1 
ATOM   791  N N    . GLY A 1 57 ? 12.616  18.935 -16.587 1.00 6.78  ? 1135 GLY A N    1 
ATOM   792  C CA   . GLY A 1 57 ? 12.147  17.590 -16.343 1.00 7.83  ? 1135 GLY A CA   1 
ATOM   793  C C    . GLY A 1 57 ? 11.460  17.022 -17.567 1.00 9.43  ? 1135 GLY A C    1 
ATOM   794  O O    . GLY A 1 57 ? 11.557  17.566 -18.658 1.00 7.45  ? 1135 GLY A O    1 
ATOM   795  H H    . GLY A 1 57 ? 12.818  19.094 -17.408 1.00 8.28  ? 1135 GLY A H    1 
ATOM   796  H HA2  . GLY A 1 57 ? 12.897  17.018 -16.115 1.00 9.54  ? 1135 GLY A HA2  1 
ATOM   797  H HA3  . GLY A 1 57 ? 11.516  17.593 -15.606 1.00 9.54  ? 1135 GLY A HA3  1 
ATOM   798  N N    . VAL A 1 58 ? 10.746  15.911 -17.343 1.00 7.18  ? 1136 VAL A N    1 
ATOM   799  C CA   . VAL A 1 58 ? 10.043  15.173 -18.394 1.00 10.39 ? 1136 VAL A CA   1 
ATOM   800  C C    . VAL A 1 58 ? 8.672   15.795 -18.627 1.00 7.22  ? 1136 VAL A C    1 
ATOM   801  O O    . VAL A 1 58 ? 8.028   16.267 -17.690 1.00 4.08  ? 1136 VAL A O    1 
ATOM   802  C CB   . VAL A 1 58 ? 9.937   13.687 -17.979 1.00 8.42  ? 1136 VAL A CB   1 
ATOM   803  C CG1  . VAL A 1 58 ? 9.261   12.822 -18.993 1.00 13.16 ? 1136 VAL A CG1  1 
ATOM   804  C CG2  . VAL A 1 58 ? 11.333  13.128 -17.703 1.00 9.24  ? 1136 VAL A CG2  1 
ATOM   805  H H    . VAL A 1 58 ? 10.653  15.555 -16.566 1.00 8.76  ? 1136 VAL A H    1 
ATOM   806  H HA   . VAL A 1 58 ? 10.533  15.234 -19.229 1.00 12.62 ? 1136 VAL A HA   1 
ATOM   807  H HB   . VAL A 1 58 ? 9.387   13.663 -17.180 1.00 10.25 ? 1136 VAL A HB   1 
ATOM   808  H HG11 . VAL A 1 58 ? 9.769   12.002 -19.097 1.00 15.94 ? 1136 VAL A HG11 1 
ATOM   809  H HG12 . VAL A 1 58 ? 8.363   12.619 -18.688 1.00 15.94 ? 1136 VAL A HG12 1 
ATOM   810  H HG13 . VAL A 1 58 ? 9.224   13.297 -19.839 1.00 15.94 ? 1136 VAL A HG13 1 
ATOM   811  H HG21 . VAL A 1 58 ? 11.263  12.178 -17.523 1.00 11.24 ? 1136 VAL A HG21 1 
ATOM   812  H HG22 . VAL A 1 58 ? 11.892  13.276 -18.482 1.00 11.24 ? 1136 VAL A HG22 1 
ATOM   813  H HG23 . VAL A 1 58 ? 11.710  13.584 -16.935 1.00 11.24 ? 1136 VAL A HG23 1 
ATOM   814  N N    . PHE A 1 59 ? 8.245   15.853 -19.887 1.00 9.58  ? 1137 PHE A N    1 
ATOM   815  C CA   . PHE A 1 59 ? 6.964   16.484 -20.171 1.00 8.44  ? 1137 PHE A CA   1 
ATOM   816  C C    . PHE A 1 59 ? 6.278   15.812 -21.335 1.00 7.04  ? 1137 PHE A C    1 
ATOM   817  O O    . PHE A 1 59 ? 6.946   15.214 -22.192 1.00 5.82  ? 1137 PHE A O    1 
ATOM   818  C CB   . PHE A 1 59 ? 7.114   17.964 -20.501 1.00 7.99  ? 1137 PHE A CB   1 
ATOM   819  C CG   . PHE A 1 59 ? 7.909   18.210 -21.724 1.00 7.27  ? 1137 PHE A CG   1 
ATOM   820  C CD1  . PHE A 1 59 ? 9.287   18.216 -21.666 1.00 5.45  ? 1137 PHE A CD1  1 
ATOM   821  C CD2  . PHE A 1 59 ? 7.300   18.401 -22.946 1.00 7.99  ? 1137 PHE A CD2  1 
ATOM   822  C CE1  . PHE A 1 59 ? 10.034  18.446 -22.790 1.00 5.84  ? 1137 PHE A CE1  1 
ATOM   823  C CE2  . PHE A 1 59 ? 8.060   18.626 -24.086 1.00 6.08  ? 1137 PHE A CE2  1 
ATOM   824  C CZ   . PHE A 1 59 ? 9.423   18.648 -24.003 1.00 6.85  ? 1137 PHE A CZ   1 
ATOM   825  H H    . PHE A 1 59 ? 8.668   15.543 -20.569 1.00 11.65 ? 1137 PHE A H    1 
ATOM   826  H HA   . PHE A 1 59 ? 6.411   16.370 -19.383 1.00 10.27 ? 1137 PHE A HA   1 
ATOM   827  H HB2  . PHE A 1 59 ? 6.233   18.347 -20.635 1.00 9.73  ? 1137 PHE A HB2  1 
ATOM   828  H HB3  . PHE A 1 59 ? 7.559   18.407 -19.761 1.00 9.73  ? 1137 PHE A HB3  1 
ATOM   829  H HD1  . PHE A 1 59 ? 9.714   18.061 -20.854 1.00 6.69  ? 1137 PHE A HD1  1 
ATOM   830  H HD2  . PHE A 1 59 ? 6.373   18.378 -23.008 1.00 9.74  ? 1137 PHE A HD2  1 
ATOM   831  H HE1  . PHE A 1 59 ? 10.962  18.466 -22.732 1.00 7.15  ? 1137 PHE A HE1  1 
ATOM   832  H HE2  . PHE A 1 59 ? 7.642   18.762 -24.905 1.00 7.44  ? 1137 PHE A HE2  1 
ATOM   833  H HZ   . PHE A 1 59 ? 9.935   18.799 -24.765 1.00 8.37  ? 1137 PHE A HZ   1 
ATOM   834  N N    . PRO A 1 60 ? 4.948   15.902 -21.405 1.00 8.07  ? 1138 PRO A N    1 
ATOM   835  C CA   . PRO A 1 60 ? 4.223   15.192 -22.450 1.00 8.91  ? 1138 PRO A CA   1 
ATOM   836  C C    . PRO A 1 60 ? 4.321   15.948 -23.757 1.00 8.65  ? 1138 PRO A C    1 
ATOM   837  O O    . PRO A 1 60 ? 4.138   17.167 -23.796 1.00 9.42  ? 1138 PRO A O    1 
ATOM   838  C CB   . PRO A 1 60 ? 2.781   15.126 -21.926 1.00 9.67  ? 1138 PRO A CB   1 
ATOM   839  C CG   . PRO A 1 60 ? 2.691   16.128 -20.809 1.00 9.51  ? 1138 PRO A CG   1 
ATOM   840  C CD   . PRO A 1 60 ? 4.063   16.698 -20.546 1.00 7.14  ? 1138 PRO A CD   1 
ATOM   841  H HA   . PRO A 1 60 ? 4.558   14.288 -22.563 1.00 10.83 ? 1138 PRO A HA   1 
ATOM   842  H HB2  . PRO A 1 60 ? 2.165   15.354 -22.640 1.00 11.75 ? 1138 PRO A HB2  1 
ATOM   843  H HB3  . PRO A 1 60 ? 2.595   14.232 -21.599 1.00 11.75 ? 1138 PRO A HB3  1 
ATOM   844  H HG2  . PRO A 1 60 ? 2.082   16.837 -21.071 1.00 11.56 ? 1138 PRO A HG2  1 
ATOM   845  H HG3  . PRO A 1 60 ? 2.359   15.683 -20.014 1.00 11.56 ? 1138 PRO A HG3  1 
ATOM   846  H HD2  . PRO A 1 60 ? 4.098   17.636 -20.793 1.00 8.71  ? 1138 PRO A HD2  1 
ATOM   847  H HD3  . PRO A 1 60 ? 4.305   16.592 -19.612 1.00 8.71  ? 1138 PRO A HD3  1 
ATOM   848  N N    . VAL A 1 61 ? 4.633   15.215 -24.824 1.00 8.42  ? 1139 VAL A N    1 
ATOM   849  C CA   . VAL A 1 61 ? 4.791   15.843 -26.135 1.00 9.35  ? 1139 VAL A CA   1 
ATOM   850  C C    . VAL A 1 61 ? 3.474   16.422 -26.620 1.00 12.65 ? 1139 VAL A C    1 
ATOM   851  O O    . VAL A 1 61 ? 3.448   17.469 -27.284 1.00 8.63  ? 1139 VAL A O    1 
ATOM   852  C CB   . VAL A 1 61 ? 5.349   14.819 -27.137 1.00 17.35 ? 1139 VAL A CB   1 
ATOM   853  C CG1  . VAL A 1 61 ? 5.391   15.405 -28.542 1.00 16.79 ? 1139 VAL A CG1  1 
ATOM   854  C CG2  . VAL A 1 61 ? 6.742   14.342 -26.666 1.00 11.15 ? 1139 VAL A CG2  1 
ATOM   855  H H    . VAL A 1 61 ? 4.757   14.364 -24.818 1.00 10.25 ? 1139 VAL A H    1 
ATOM   856  H HA   . VAL A 1 61 ? 5.424   16.574 -26.053 1.00 11.37 ? 1139 VAL A HA   1 
ATOM   857  H HB   . VAL A 1 61 ? 4.766   14.045 -27.177 1.00 20.97 ? 1139 VAL A HB   1 
ATOM   858  H HG11 . VAL A 1 61 ? 5.965   14.855 -29.097 1.00 20.30 ? 1139 VAL A HG11 1 
ATOM   859  H HG12 . VAL A 1 61 ? 4.492   15.416 -28.906 1.00 20.30 ? 1139 VAL A HG12 1 
ATOM   860  H HG13 . VAL A 1 61 ? 5.741   16.309 -28.497 1.00 20.30 ? 1139 VAL A HG13 1 
ATOM   861  H HG21 . VAL A 1 61 ? 7.145   13.806 -27.366 1.00 13.52 ? 1139 VAL A HG21 1 
ATOM   862  H HG22 . VAL A 1 61 ? 7.295   15.117 -26.482 1.00 13.52 ? 1139 VAL A HG22 1 
ATOM   863  H HG23 . VAL A 1 61 ? 6.638   13.811 -25.861 1.00 13.52 ? 1139 VAL A HG23 1 
ATOM   864  N N    . SER A 1 62 ? 2.361   15.781 -26.263 1.00 9.75  ? 1140 SER A N    1 
ATOM   865  C CA   . SER A 1 62 ? 1.062   16.245 -26.695 1.00 16.24 ? 1140 SER A CA   1 
ATOM   866  C C    . SER A 1 62 ? 0.710   17.581 -26.083 1.00 17.89 ? 1140 SER A C    1 
ATOM   867  O O    . SER A 1 62 ? -0.229  18.226 -26.549 1.00 11.22 ? 1140 SER A O    1 
ATOM   868  C CB   . SER A 1 62 ? -0.013  15.221 -26.301 1.00 9.21  ? 1140 SER A CB   1 
ATOM   869  O OG   . SER A 1 62 ? 0.019   14.958 -24.895 1.00 12.72 ? 1140 SER A OG   1 
ATOM   870  H H    . SER A 1 62 ? 2.340   15.076 -25.771 1.00 11.84 ? 1140 SER A H    1 
ATOM   871  H HA   . SER A 1 62 ? 1.063   16.332 -27.661 1.00 19.63 ? 1140 SER A HA   1 
ATOM   872  H HB2  . SER A 1 62 ? -0.886  15.574 -26.536 1.00 11.19 ? 1140 SER A HB2  1 
ATOM   873  H HB3  . SER A 1 62 ? 0.150   14.393 -26.780 1.00 11.19 ? 1140 SER A HB3  1 
ATOM   874  H HG   . SER A 1 62 ? -0.587  14.414 -24.690 1.00 15.41 ? 1140 SER A HG   1 
ATOM   875  N N    . PHE A 1 63 ? 1.482   18.059 -25.118 1.00 9.31  ? 1141 PHE A N    1 
ATOM   876  C CA   . PHE A 1 63 ? 1.152   19.317 -24.480 1.00 5.47  ? 1141 PHE A CA   1 
ATOM   877  C C    . PHE A 1 63 ? 1.921   20.478 -25.075 1.00 8.25  ? 1141 PHE A C    1 
ATOM   878  O O    . PHE A 1 63 ? 1.843   21.585 -24.535 1.00 8.94  ? 1141 PHE A O    1 
ATOM   879  C CB   . PHE A 1 63 ? 1.422   19.250 -22.978 1.00 11.47 ? 1141 PHE A CB   1 
ATOM   880  C CG   . PHE A 1 63 ? 0.351   18.606 -22.178 1.00 8.12  ? 1141 PHE A CG   1 
ATOM   881  C CD1  . PHE A 1 63 ? -0.157  17.372 -22.527 1.00 9.88  ? 1141 PHE A CD1  1 
ATOM   882  C CD2  . PHE A 1 63 ? -0.096  19.208 -21.017 1.00 13.47 ? 1141 PHE A CD2  1 
ATOM   883  C CE1  . PHE A 1 63 ? -1.097  16.762 -21.735 1.00 15.87 ? 1141 PHE A CE1  1 
ATOM   884  C CE2  . PHE A 1 63 ? -1.061  18.603 -20.227 1.00 10.50 ? 1141 PHE A CE2  1 
ATOM   885  C CZ   . PHE A 1 63 ? -1.551  17.373 -20.591 1.00 12.14 ? 1141 PHE A CZ   1 
ATOM   886  H H    . PHE A 1 63 ? 2.192   17.676 -24.822 1.00 11.32 ? 1141 PHE A H    1 
ATOM   887  H HA   . PHE A 1 63 ? 0.203   19.478 -24.603 1.00 6.70  ? 1141 PHE A HA   1 
ATOM   888  H HB2  . PHE A 1 63 ? 2.237   18.743 -22.835 1.00 13.92 ? 1141 PHE A HB2  1 
ATOM   889  H HB3  . PHE A 1 63 ? 1.531   20.154 -22.644 1.00 13.92 ? 1141 PHE A HB3  1 
ATOM   890  H HD1  . PHE A 1 63 ? 0.139   16.952 -23.302 1.00 12.01 ? 1141 PHE A HD1  1 
ATOM   891  H HD2  . PHE A 1 63 ? 0.255   20.030 -20.762 1.00 16.31 ? 1141 PHE A HD2  1 
ATOM   892  H HE1  . PHE A 1 63 ? -1.430  15.928 -21.975 1.00 19.19 ? 1141 PHE A HE1  1 
ATOM   893  H HE2  . PHE A 1 63 ? -1.372  19.026 -19.459 1.00 12.75 ? 1141 PHE A HE2  1 
ATOM   894  H HZ   . PHE A 1 63 ? -2.192  16.953 -20.063 1.00 14.72 ? 1141 PHE A HZ   1 
ATOM   895  N N    . VAL A 1 64 ? 2.664   20.260 -26.174 1.00 7.91  ? 1142 VAL A N    1 
ATOM   896  C CA   . VAL A 1 64 ? 3.486   21.302 -26.771 1.00 10.49 ? 1142 VAL A CA   1 
ATOM   897  C C    . VAL A 1 64 ? 3.313   21.345 -28.283 1.00 8.78  ? 1142 VAL A C    1 
ATOM   898  O O    . VAL A 1 64 ? 2.878   20.388 -28.925 1.00 8.44  ? 1142 VAL A O    1 
ATOM   899  C CB   . VAL A 1 64 ? 4.984   21.141 -26.421 1.00 6.54  ? 1142 VAL A CB   1 
ATOM   900  C CG1  . VAL A 1 64 ? 5.121   20.842 -24.900 1.00 6.43  ? 1142 VAL A CG1  1 
ATOM   901  C CG2  . VAL A 1 64 ? 5.653   20.077 -27.286 1.00 8.27  ? 1142 VAL A CG2  1 
ATOM   902  H H    . VAL A 1 64 ? 2.703   19.507 -26.587 1.00 9.64  ? 1142 VAL A H    1 
ATOM   903  H HA   . VAL A 1 64 ? 3.163   22.150 -26.428 1.00 12.73 ? 1142 VAL A HA   1 
ATOM   904  H HB   . VAL A 1 64 ? 5.457   21.965 -26.614 1.00 7.99  ? 1142 VAL A HB   1 
ATOM   905  H HG11 . VAL A 1 64 ? 6.060   20.854 -24.659 1.00 7.86  ? 1142 VAL A HG11 1 
ATOM   906  H HG12 . VAL A 1 64 ? 4.643   21.523 -24.401 1.00 7.86  ? 1142 VAL A HG12 1 
ATOM   907  H HG13 . VAL A 1 64 ? 4.742   19.969 -24.714 1.00 7.86  ? 1142 VAL A HG13 1 
ATOM   908  H HG21 . VAL A 1 64 ? 6.482   19.802 -26.864 1.00 10.07 ? 1142 VAL A HG21 1 
ATOM   909  H HG22 . VAL A 1 64 ? 5.056   19.317 -27.370 1.00 10.07 ? 1142 VAL A HG22 1 
ATOM   910  H HG23 . VAL A 1 64 ? 5.836   20.451 -28.162 1.00 10.07 ? 1142 VAL A HG23 1 
ATOM   911  N N    . HIS A 1 65 ? 3.641   22.492 -28.836 1.00 5.31  ? 1143 HIS A N    1 
ATOM   912  C CA   . HIS A 1 65 ? 3.734   22.659 -30.272 1.00 12.15 ? 1143 HIS A CA   1 
ATOM   913  C C    . HIS A 1 65 ? 5.188   22.858 -30.632 1.00 11.07 ? 1143 HIS A C    1 
ATOM   914  O O    . HIS A 1 65 ? 5.889   23.633 -29.981 1.00 10.69 ? 1143 HIS A O    1 
ATOM   915  C CB   . HIS A 1 65 ? 2.918   23.859 -30.737 1.00 16.92 ? 1143 HIS A CB   1 
ATOM   916  C CG   . HIS A 1 65 ? 1.477   23.551 -30.970 1.00 29.58 ? 1143 HIS A CG   1 
ATOM   917  N ND1  . HIS A 1 65 ? 0.593   24.485 -31.470 1.00 27.58 ? 1143 HIS A ND1  1 
ATOM   918  C CD2  . HIS A 1 65 ? 0.763   22.417 -30.781 1.00 22.62 ? 1143 HIS A CD2  1 
ATOM   919  C CE1  . HIS A 1 65 ? -0.594  23.928 -31.609 1.00 25.05 ? 1143 HIS A CE1  1 
ATOM   920  N NE2  . HIS A 1 65 ? -0.522  22.680 -31.185 1.00 22.17 ? 1143 HIS A NE2  1 
ATOM   921  H H    . HIS A 1 65 ? 3.819   23.206 -28.391 1.00 6.52  ? 1143 HIS A H    1 
ATOM   922  H HA   . HIS A 1 65 ? 3.393   21.874 -30.729 1.00 14.73 ? 1143 HIS A HA   1 
ATOM   923  H HB2  . HIS A 1 65 ? 2.967   24.551 -30.059 1.00 20.45 ? 1143 HIS A HB2  1 
ATOM   924  H HB3  . HIS A 1 65 ? 3.290   24.185 -31.571 1.00 20.45 ? 1143 HIS A HB3  1 
ATOM   925  H HD2  . HIS A 1 65 ? 1.083   21.612 -30.442 1.00 27.29 ? 1143 HIS A HD2  1 
ATOM   926  H HE1  . HIS A 1 65 ? -1.353  24.345 -31.948 1.00 30.21 ? 1143 HIS A HE1  1 
ATOM   927  H HE2  . HIS A 1 65 ? -1.176  22.121 -31.166 1.00 26.75 ? 1143 HIS A HE2  1 
ATOM   928  N N    . ILE A 1 66 ? 5.630   22.180 -31.678 1.00 14.08 ? 1144 ILE A N    1 
ATOM   929  C CA   . ILE A 1 66 ? 7.006   22.335 -32.139 1.00 14.93 ? 1144 ILE A CA   1 
ATOM   930  C C    . ILE A 1 66 ? 7.243   23.759 -32.619 1.00 19.02 ? 1144 ILE A C    1 
ATOM   931  O O    . ILE A 1 66 ? 6.470   24.310 -33.418 1.00 21.23 ? 1144 ILE A O    1 
ATOM   932  C CB   . ILE A 1 66 ? 7.322   21.338 -33.259 1.00 13.81 ? 1144 ILE A CB   1 
ATOM   933  C CG1  . ILE A 1 66 ? 7.176   19.882 -32.811 1.00 20.04 ? 1144 ILE A CG1  1 
ATOM   934  C CG2  . ILE A 1 66 ? 8.748   21.601 -33.763 1.00 26.04 ? 1144 ILE A CG2  1 
ATOM   935  C CD1  . ILE A 1 66 ? 7.518   19.621 -31.415 1.00 30.91 ? 1144 ILE A CD1  1 
ATOM   936  H H    . ILE A 1 66 ? 5.160   21.627 -32.139 1.00 17.05 ? 1144 ILE A H    1 
ATOM   937  H HA   . ILE A 1 66 ? 7.590   22.157 -31.385 1.00 18.06 ? 1144 ILE A HA   1 
ATOM   938  H HB   . ILE A 1 66 ? 6.677   21.472 -33.971 1.00 16.72 ? 1144 ILE A HB   1 
ATOM   939  H HG12 . ILE A 1 66 ? 6.252   19.615 -32.937 1.00 24.20 ? 1144 ILE A HG12 1 
ATOM   940  H HG13 . ILE A 1 66 ? 7.758   19.334 -33.359 1.00 24.20 ? 1144 ILE A HG13 1 
ATOM   941  H HG21 . ILE A 1 66 ? 8.968   20.947 -34.444 1.00 31.40 ? 1144 ILE A HG21 1 
ATOM   942  H HG22 . ILE A 1 66 ? 8.791   22.495 -34.136 1.00 31.40 ? 1144 ILE A HG22 1 
ATOM   943  H HG23 . ILE A 1 66 ? 9.365   21.523 -33.018 1.00 31.40 ? 1144 ILE A HG23 1 
ATOM   944  H HD11 . ILE A 1 66 ? 7.469   18.666 -31.251 1.00 37.23 ? 1144 ILE A HD11 1 
ATOM   945  H HD12 . ILE A 1 66 ? 8.418   19.940 -31.245 1.00 37.23 ? 1144 ILE A HD12 1 
ATOM   946  H HD13 . ILE A 1 66 ? 6.889   20.088 -30.843 1.00 37.23 ? 1144 ILE A HD13 1 
ATOM   947  N N    . LEU A 1 67 ? 8.343   24.349 -32.172 1.00 11.29 ? 1145 LEU A N    1 
ATOM   948  C CA   . LEU A 1 67 ? 8.663   25.728 -32.503 1.00 18.24 ? 1145 LEU A CA   1 
ATOM   949  C C    . LEU A 1 67 ? 9.896   25.842 -33.382 1.00 26.77 ? 1145 LEU A C    1 
ATOM   950  O O    . LEU A 1 67 ? 9.850   26.503 -34.421 1.00 36.81 ? 1145 LEU A O    1 
ATOM   951  C CB   . LEU A 1 67 ? 8.877   26.526 -31.220 1.00 16.99 ? 1145 LEU A CB   1 
ATOM   952  C CG   . LEU A 1 67 ? 8.362   27.935 -31.075 1.00 24.32 ? 1145 LEU A CG   1 
ATOM   953  C CD1  . LEU A 1 67 ? 6.908   28.013 -31.409 1.00 21.04 ? 1145 LEU A CD1  1 
ATOM   954  C CD2  . LEU A 1 67 ? 8.680   28.326 -29.623 1.00 19.63 ? 1145 LEU A CD2  1 
ATOM   955  H H    . LEU A 1 67 ? 8.926   23.965 -31.669 1.00 13.69 ? 1145 LEU A H    1 
ATOM   956  H HA   . LEU A 1 67 ? 7.916   26.118 -32.984 1.00 22.04 ? 1145 LEU A HA   1 
ATOM   957  H HB2  . LEU A 1 67 ? 8.464   26.020 -30.502 1.00 20.53 ? 1145 LEU A HB2  1 
ATOM   958  H HB3  . LEU A 1 67 ? 9.835   26.580 -31.079 1.00 20.53 ? 1145 LEU A HB3  1 
ATOM   959  H HG   . LEU A 1 67 ? 8.775   28.562 -31.689 1.00 29.33 ? 1145 LEU A HG   1 
ATOM   960  H HD11 . LEU A 1 67 ? 6.570   28.883 -31.146 1.00 25.40 ? 1145 LEU A HD11 1 
ATOM   961  H HD12 . LEU A 1 67 ? 6.796   27.891 -32.365 1.00 25.40 ? 1145 LEU A HD12 1 
ATOM   962  H HD13 . LEU A 1 67 ? 6.435   27.315 -30.929 1.00 25.40 ? 1145 LEU A HD13 1 
ATOM   963  H HD21 . LEU A 1 67 ? 8.297   29.198 -29.440 1.00 23.70 ? 1145 LEU A HD21 1 
ATOM   964  H HD22 . LEU A 1 67 ? 8.297   27.665 -29.026 1.00 23.70 ? 1145 LEU A HD22 1 
ATOM   965  H HD23 . LEU A 1 67 ? 9.643   28.357 -29.508 1.00 23.70 ? 1145 LEU A HD23 1 
ATOM   966  N N    . SER A 1 68 ? 11.008  25.221 -32.977 1.00 27.70 ? 1146 SER A N    1 
ATOM   967  C CA   . SER A 1 68 ? 12.272  25.311 -33.691 1.00 28.99 ? 1146 SER A CA   1 
ATOM   968  C C    . SER A 1 68 ? 12.921  23.942 -33.850 1.00 33.18 ? 1146 SER A C    1 
ATOM   969  O O    . SER A 1 68 ? 12.889  23.118 -32.933 1.00 25.02 ? 1146 SER A O    1 
ATOM   970  C CB   . SER A 1 68 ? 13.269  26.224 -32.967 1.00 22.19 ? 1146 SER A CB   1 
ATOM   971  O OG   . SER A 1 68 ? 12.798  27.558 -32.852 1.00 26.70 ? 1146 SER A OG   1 
ATOM   972  H H    . SER A 1 68 ? 11.051  24.730 -32.272 1.00 33.39 ? 1146 SER A H    1 
ATOM   973  H HA   . SER A 1 68 ? 12.078  25.663 -34.573 1.00 34.93 ? 1146 SER A HA   1 
ATOM   974  H HB2  . SER A 1 68 ? 13.420  25.872 -32.076 1.00 26.78 ? 1146 SER A HB2  1 
ATOM   975  H HB3  . SER A 1 68 ? 14.100  26.231 -33.467 1.00 26.78 ? 1146 SER A HB3  1 
ATOM   976  H HG   . SER A 1 68 ? 12.647  27.876 -33.615 1.00 32.19 ? 1146 SER A HG   1 
ATOM   977  N N    . ASP A 1 69 ? 13.538  23.736 -35.016 1.00 42.87 ? 1147 ASP A N    1 
ATOM   978  C CA   . ASP A 1 69 ? 14.406  22.592 -35.309 1.00 45.79 ? 1147 ASP A CA   1 
ATOM   979  C C    . ASP A 1 69 ? 13.623  21.293 -35.174 1.00 45.32 ? 1147 ASP A C    1 
ATOM   980  O O    . ASP A 1 69 ? 12.582  21.117 -35.813 1.00 48.44 ? 1147 ASP A O    1 
ATOM   981  C CB   . ASP A 1 69 ? 15.639  22.611 -34.388 1.00 46.07 ? 1147 ASP A CB   1 
ATOM   982  C CG   . ASP A 1 69 ? 16.838  21.852 -34.968 1.00 52.14 ? 1147 ASP A CG   1 
ATOM   983  O OD1  . ASP A 1 69 ? 17.139  22.009 -36.178 1.00 63.59 ? 1147 ASP A OD1  1 
ATOM   984  O OD2  . ASP A 1 69 ? 17.486  21.098 -34.196 1.00 49.55 ? 1147 ASP A OD2  1 
ATOM   985  H H    . ASP A 1 69 ? 13.466  24.269 -35.687 1.00 51.59 ? 1147 ASP A H    1 
ATOM   986  H HA   . ASP A 1 69 ? 14.735  22.642 -36.221 1.00 55.09 ? 1147 ASP A HA   1 
ATOM   987  H HB2  . ASP A 1 69 ? 15.910  23.532 -34.245 1.00 55.43 ? 1147 ASP A HB2  1 
ATOM   988  H HB3  . ASP A 1 69 ? 15.405  22.199 -33.542 1.00 55.43 ? 1147 ASP A HB3  1 
ATOM   989  N N    . ILE B 2 2  ? -8.555  16.536 -22.079 1.00 54.55 ? 1700 ILE E N    1 
ATOM   990  C CA   . ILE B 2 2  ? -7.178  16.490 -22.594 1.00 49.58 ? 1700 ILE E CA   1 
ATOM   991  C C    . ILE B 2 2  ? -6.352  15.677 -21.612 1.00 32.56 ? 1700 ILE E C    1 
ATOM   992  O O    . ILE B 2 2  ? -5.883  16.176 -20.580 1.00 39.64 ? 1700 ILE E O    1 
ATOM   993  C CB   . ILE B 2 2  ? -6.570  17.859 -22.825 1.00 37.86 ? 1700 ILE E CB   1 
ATOM   994  C CG1  . ILE B 2 2  ? -7.599  18.735 -23.527 1.00 41.81 ? 1700 ILE E CG1  1 
ATOM   995  C CG2  . ILE B 2 2  ? -5.279  17.667 -23.641 1.00 38.93 ? 1700 ILE E CG2  1 
ATOM   996  C CD1  . ILE B 2 2  ? -8.540  19.396 -22.566 1.00 40.86 ? 1700 ILE E CD1  1 
ATOM   997  H HA   . ILE B 2 2  ? -7.182  16.071 -23.469 1.00 59.65 ? 1700 ILE E HA   1 
ATOM   998  H HB   . ILE B 2 2  ? -6.337  18.304 -21.995 1.00 45.57 ? 1700 ILE E HB   1 
ATOM   999  H HG12 . ILE B 2 2  ? -7.139  19.429 -24.024 1.00 50.31 ? 1700 ILE E HG12 1 
ATOM   1000 H HG13 . ILE B 2 2  ? -8.123  18.186 -24.132 1.00 50.31 ? 1700 ILE E HG13 1 
ATOM   1001 H HG21 . ILE B 2 2  ? -4.922  18.537 -23.877 1.00 46.86 ? 1700 ILE E HG21 1 
ATOM   1002 H HG22 . ILE B 2 2  ? -4.635  17.180 -23.103 1.00 46.86 ? 1700 ILE E HG22 1 
ATOM   1003 H HG23 . ILE B 2 2  ? -5.485  17.165 -24.445 1.00 46.86 ? 1700 ILE E HG23 1 
ATOM   1004 H HD11 . ILE B 2 2  ? -9.131  19.987 -23.058 1.00 49.18 ? 1700 ILE E HD11 1 
ATOM   1005 H HD12 . ILE B 2 2  ? -9.059  18.713 -22.112 1.00 49.18 ? 1700 ILE E HD12 1 
ATOM   1006 H HD13 . ILE B 2 2  ? -8.026  19.904 -21.920 1.00 49.18 ? 1700 ILE E HD13 1 
ATOM   1007 N N    . LYS B 2 3  ? -6.177  14.405 -21.948 1.00 31.93 ? 1701 LYS E N    1 
ATOM   1008 C CA   . LYS B 2 3  ? -5.547  13.455 -21.046 1.00 25.71 ? 1701 LYS E CA   1 
ATOM   1009 C C    . LYS B 2 3  ? -4.040  13.361 -21.245 1.00 19.05 ? 1701 LYS E C    1 
ATOM   1010 O O    . LYS B 2 3  ? -3.537  13.337 -22.368 1.00 23.58 ? 1701 LYS E O    1 
ATOM   1011 C CB   . LYS B 2 3  ? -6.171  12.072 -21.240 1.00 24.88 ? 1701 LYS E CB   1 
ATOM   1012 H H    . LYS B 2 3  ? -6.417  14.067 -22.701 1.00 38.47 ? 1701 LYS E H    1 
ATOM   1013 H HA   . LYS B 2 3  ? -5.688  13.763 -20.137 1.00 31.00 ? 1701 LYS E HA   1 
ATOM   1014 N N    . LYS B 2 4  ? -3.343  13.321 -20.152 1.00 17.43 ? 1702 LYS E N    1 
ATOM   1015 C CA   . LYS B 2 4  ? -1.909  13.152 -20.179 1.00 19.84 ? 1702 LYS E CA   1 
ATOM   1016 C C    . LYS B 2 4  ? -1.610  11.674 -20.420 1.00 15.04 ? 1702 LYS E C    1 
ATOM   1017 O O    . LYS B 2 4  ? -2.205  10.815 -19.772 1.00 22.13 ? 1702 LYS E O    1 
ATOM   1018 C CB   . LYS B 2 4  ? -1.340  13.641 -18.853 1.00 16.67 ? 1702 LYS E CB   1 
ATOM   1019 C CG   . LYS B 2 4  ? 0.148   13.758 -18.761 1.00 23.89 ? 1702 LYS E CG   1 
ATOM   1020 C CD   . LYS B 2 4  ? 0.562   14.033 -17.296 1.00 10.66 ? 1702 LYS E CD   1 
ATOM   1021 C CE   . LYS B 2 4  ? 0.035   15.368 -16.834 1.00 11.77 ? 1702 LYS E CE   1 
ATOM   1022 N NZ   . LYS B 2 4  ? 0.779   15.910 -15.686 1.00 11.93 ? 1702 LYS E NZ   1 
ATOM   1023 H H    . LYS B 2 4  ? -3.673  13.389 -19.361 1.00 21.06 ? 1702 LYS E H    1 
ATOM   1024 H HA   . LYS B 2 4  ? -1.483  13.659 -20.888 1.00 23.96 ? 1702 LYS E HA   1 
ATOM   1025 H HB2  . LYS B 2 4  ? -1.705  14.523 -18.677 1.00 20.16 ? 1702 LYS E HB2  1 
ATOM   1026 H HB3  . LYS B 2 4  ? -1.619  13.023 -18.160 1.00 20.16 ? 1702 LYS E HB3  1 
ATOM   1027 H HG2  . LYS B 2 4  ? 0.560   12.929 -19.052 1.00 28.82 ? 1702 LYS E HG2  1 
ATOM   1028 H HG3  . LYS B 2 4  ? 0.454   14.493 -19.315 1.00 28.82 ? 1702 LYS E HG3  1 
ATOM   1029 H HD2  . LYS B 2 4  ? 0.197   13.342 -16.721 1.00 12.94 ? 1702 LYS E HD2  1 
ATOM   1030 H HD3  . LYS B 2 4  ? 1.529   14.044 -17.229 1.00 12.94 ? 1702 LYS E HD3  1 
ATOM   1031 H HE2  . LYS B 2 4  ? 0.104   16.004 -17.562 1.00 14.27 ? 1702 LYS E HE2  1 
ATOM   1032 H HE3  . LYS B 2 4  ? -0.892  15.266 -16.568 1.00 14.27 ? 1702 LYS E HE3  1 
ATOM   1033 H HZ1  . LYS B 2 4  ? 0.695   15.368 -14.985 1.00 14.46 ? 1702 LYS E HZ1  1 
ATOM   1034 H HZ2  . LYS B 2 4  ? 1.642   15.986 -15.890 1.00 14.46 ? 1702 LYS E HZ2  1 
ATOM   1035 H HZ3  . LYS B 2 4  ? 0.462   16.713 -15.469 1.00 14.46 ? 1702 LYS E HZ3  1 
ATOM   1036 N N    . PRO B 2 5  ? -0.764  11.332 -21.383 1.00 16.43 ? 1703 PRO E N    1 
ATOM   1037 C CA   . PRO B 2 5  ? -0.427  9.918  -21.574 1.00 16.49 ? 1703 PRO E CA   1 
ATOM   1038 C C    . PRO B 2 5  ? 0.294   9.378  -20.349 1.00 20.70 ? 1703 PRO E C    1 
ATOM   1039 O O    . PRO B 2 5  ? 0.964   10.108 -19.613 1.00 19.16 ? 1703 PRO E O    1 
ATOM   1040 C CB   . PRO B 2 5  ? 0.484   9.935  -22.805 1.00 19.02 ? 1703 PRO E CB   1 
ATOM   1041 C CG   . PRO B 2 5  ? 1.144   11.319 -22.763 1.00 20.27 ? 1703 PRO E CG   1 
ATOM   1042 C CD   . PRO B 2 5  ? 0.020   12.217 -22.255 1.00 19.43 ? 1703 PRO E CD   1 
ATOM   1043 H HA   . PRO B 2 5  ? -1.213  9.382  -21.764 1.00 19.93 ? 1703 PRO E HA   1 
ATOM   1044 H HB2  . PRO B 2 5  ? 1.146   9.229  -22.740 1.00 22.97 ? 1703 PRO E HB2  1 
ATOM   1045 H HB3  . PRO B 2 5  ? -0.042  9.822  -23.612 1.00 22.97 ? 1703 PRO E HB3  1 
ATOM   1046 H HG2  . PRO B 2 5  ? 1.899   11.316 -22.153 1.00 24.46 ? 1703 PRO E HG2  1 
ATOM   1047 H HG3  . PRO B 2 5  ? 1.436   11.583 -23.649 1.00 24.46 ? 1703 PRO E HG3  1 
ATOM   1048 H HD2  . PRO B 2 5  ? 0.378   12.965 -21.753 1.00 23.47 ? 1703 PRO E HD2  1 
ATOM   1049 H HD3  . PRO B 2 5  ? -0.521  12.540 -22.992 1.00 23.47 ? 1703 PRO E HD3  1 
ATOM   1050 N N    . VAL B 2 6  ? 0.203   8.080  -20.161 1.00 21.23 ? 1704 VAL E N    1 
ATOM   1051 C CA   . VAL B 2 6  ? 0.790   7.492  -18.969 1.00 17.97 ? 1704 VAL E CA   1 
ATOM   1052 C C    . VAL B 2 6  ? 2.296   7.430  -19.168 1.00 18.23 ? 1704 VAL E C    1 
ATOM   1053 O O    . VAL B 2 6  ? 2.791   7.365  -20.308 1.00 15.55 ? 1704 VAL E O    1 
ATOM   1054 C CB   . VAL B 2 6  ? 0.215   6.089  -18.650 1.00 17.57 ? 1704 VAL E CB   1 
ATOM   1055 C CG1  . VAL B 2 6  ? -1.274  6.143  -18.361 1.00 19.29 ? 1704 VAL E CG1  1 
ATOM   1056 C CG2  . VAL B 2 6  ? 0.539   5.096  -19.742 1.00 20.22 ? 1704 VAL E CG2  1 
ATOM   1057 H H    . VAL B 2 6  ? -0.184  7.527  -20.694 1.00 25.62 ? 1704 VAL E H    1 
ATOM   1058 H HA   . VAL B 2 6  ? 0.572   8.057  -18.211 1.00 21.71 ? 1704 VAL E HA   1 
ATOM   1059 H HB   . VAL B 2 6  ? 0.645   5.773  -17.840 1.00 21.23 ? 1704 VAL E HB   1 
ATOM   1060 H HG11 . VAL B 2 6  ? -1.592  5.246  -18.173 1.00 23.29 ? 1704 VAL E HG11 1 
ATOM   1061 H HG12 . VAL B 2 6  ? -1.427  6.715  -17.593 1.00 23.29 ? 1704 VAL E HG12 1 
ATOM   1062 H HG13 . VAL B 2 6  ? -1.733  6.500  -19.137 1.00 23.29 ? 1704 VAL E HG13 1 
ATOM   1063 H HG21 . VAL B 2 6  ? 0.077   4.263  -19.558 1.00 24.41 ? 1704 VAL E HG21 1 
ATOM   1064 H HG22 . VAL B 2 6  ? 0.244   5.456  -20.594 1.00 24.41 ? 1704 VAL E HG22 1 
ATOM   1065 H HG23 . VAL B 2 6  ? 1.497   4.947  -19.760 1.00 24.41 ? 1704 VAL E HG23 1 
ATOM   1066 N N    . ARG B 2 7  ? 3.025   7.505  -18.046 1.00 13.59 ? 1705 ARG E N    1 
ATOM   1067 C CA   . ARG B 2 7  ? 4.453   7.214  -18.022 1.00 18.27 ? 1705 ARG E CA   1 
ATOM   1068 C C    . ARG B 2 7  ? 4.613   5.708  -18.087 1.00 18.51 ? 1705 ARG E C    1 
ATOM   1069 O O    . ARG B 2 7  ? 3.804   4.970  -17.529 1.00 23.17 ? 1705 ARG E O    1 
ATOM   1070 C CB   . ARG B 2 7  ? 5.120   7.774  -16.763 1.00 15.23 ? 1705 ARG E CB   1 
ATOM   1071 C CG   . ARG B 2 7  ? 5.017   9.279  -16.631 1.00 11.90 ? 1705 ARG E CG   1 
ATOM   1072 C CD   . ARG B 2 7  ? 6.055   10.070 -17.481 1.00 12.23 ? 1705 ARG E CD   1 
ATOM   1073 N NE   . ARG B 2 7  ? 7.442   9.671  -17.244 1.00 10.71 ? 1705 ARG E NE   1 
ATOM   1074 C CZ   . ARG B 2 7  ? 8.226   10.129 -16.274 1.00 9.60  ? 1705 ARG E CZ   1 
ATOM   1075 N NH1  . ARG B 2 7  ? 7.762   10.878 -15.299 1.00 8.86  ? 1705 ARG E NH1  1 
ATOM   1076 N NH2  . ARG B 2 7  ? 9.504   9.769  -16.252 1.00 10.13 ? 1705 ARG E NH2  1 
ATOM   1077 H H    . ARG B 2 7  ? 2.707   7.727  -17.278 1.00 16.46 ? 1705 ARG E H    1 
ATOM   1078 H HA   . ARG B 2 7  ? 4.903   7.633  -18.772 1.00 22.07 ? 1705 ARG E HA   1 
ATOM   1079 H HB2  . ARG B 2 7  ? 4.695   7.380  -15.984 1.00 18.43 ? 1705 ARG E HB2  1 
ATOM   1080 H HB3  . ARG B 2 7  ? 6.061   7.542  -16.780 1.00 18.43 ? 1705 ARG E HB3  1 
ATOM   1081 H HG2  . ARG B 2 7  ? 4.133   9.556  -16.918 1.00 14.43 ? 1705 ARG E HG2  1 
ATOM   1082 H HG3  . ARG B 2 7  ? 5.155   9.520  -15.702 1.00 14.43 ? 1705 ARG E HG3  1 
ATOM   1083 H HD2  . ARG B 2 7  ? 5.863   9.926  -18.421 1.00 14.83 ? 1705 ARG E HD2  1 
ATOM   1084 H HD3  . ARG B 2 7  ? 5.979   11.013 -17.267 1.00 14.83 ? 1705 ARG E HD3  1 
ATOM   1085 H HE   . ARG B 2 7  ? 7.779   9.089  -17.780 1.00 13.00 ? 1705 ARG E HE   1 
ATOM   1086 H HH11 . ARG B 2 7  ? 6.928   11.086 -15.277 1.00 10.78 ? 1705 ARG E HH11 1 
ATOM   1087 H HH12 . ARG B 2 7  ? 8.292   11.161 -14.684 1.00 10.78 ? 1705 ARG E HH12 1 
ATOM   1088 H HH21 . ARG B 2 7  ? 9.814   9.247  -16.860 1.00 12.30 ? 1705 ARG E HH21 1 
ATOM   1089 H HH22 . ARG B 2 7  ? 10.021  10.059 -15.629 1.00 12.30 ? 1705 ARG E HH22 1 
ATOM   1090 N N    . ARG B 2 8  ? 5.589   5.243  -18.846 1.00 29.19 ? 1706 ARG E N    1 
ATOM   1091 C CA   . ARG B 2 8  ? 5.882   3.812  -18.841 1.00 31.74 ? 1706 ARG E CA   1 
ATOM   1092 C C    . ARG B 2 8  ? 7.335   3.476  -19.144 1.00 32.87 ? 1706 ARG E C    1 
ATOM   1093 O O    . ARG B 2 8  ? 8.200   3.826  -18.350 1.00 39.19 ? 1706 ARG E O    1 
ATOM   1094 C CB   . ARG B 2 8  ? 4.960   3.117  -19.831 1.00 37.98 ? 1706 ARG E CB   1 
ATOM   1095 C CG   . ARG B 2 8  ? 5.123   3.637  -21.227 1.00 35.51 ? 1706 ARG E CG   1 
ATOM   1096 C CD   . ARG B 2 8  ? 4.984   2.497  -22.183 1.00 29.00 ? 1706 ARG E CD   1 
ATOM   1097 N NE   . ARG B 2 8  ? 3.619   2.265  -22.621 1.00 21.28 ? 1706 ARG E NE   1 
ATOM   1098 C CZ   . ARG B 2 8  ? 3.332   1.697  -23.782 1.00 18.62 ? 1706 ARG E CZ   1 
ATOM   1099 N NH1  . ARG B 2 8  ? 4.296   1.286  -24.604 1.00 16.50 ? 1706 ARG E NH1  1 
ATOM   1100 N NH2  . ARG B 2 8  ? 2.060   1.538  -24.132 1.00 33.30 ? 1706 ARG E NH2  1 
ATOM   1101 H H    . ARG B 2 8  ? 6.087   5.719  -19.360 1.00 35.18 ? 1706 ARG E H    1 
ATOM   1102 H HA   . ARG B 2 8  ? 5.725   3.474  -17.946 1.00 38.24 ? 1706 ARG E HA   1 
ATOM   1103 H HB2  . ARG B 2 8  ? 5.160   2.168  -19.838 1.00 45.72 ? 1706 ARG E HB2  1 
ATOM   1104 H HB3  . ARG B 2 8  ? 4.039   3.261  -19.562 1.00 45.72 ? 1706 ARG E HB3  1 
ATOM   1105 H HG2  . ARG B 2 8  ? 4.437   4.295  -21.418 1.00 42.76 ? 1706 ARG E HG2  1 
ATOM   1106 H HG3  . ARG B 2 8  ? 6.002   4.033  -21.333 1.00 42.76 ? 1706 ARG E HG3  1 
ATOM   1107 H HD2  . ARG B 2 8  ? 5.520   2.682  -22.970 1.00 34.94 ? 1706 ARG E HD2  1 
ATOM   1108 H HD3  . ARG B 2 8  ? 5.298   1.687  -21.751 1.00 34.94 ? 1706 ARG E HD3  1 
ATOM   1109 H HE   . ARG B 2 8  ? 2.973   2.506  -22.107 1.00 25.68 ? 1706 ARG E HE   1 
ATOM   1110 H HH11 . ARG B 2 8  ? 5.121   1.388  -24.384 1.00 19.95 ? 1706 ARG E HH11 1 
ATOM   1111 H HH12 . ARG B 2 8  ? 4.093   0.919  -25.355 1.00 19.95 ? 1706 ARG E HH12 1 
ATOM   1112 H HH21 . ARG B 2 8  ? 1.433   1.803  -23.606 1.00 40.10 ? 1706 ARG E HH21 1 
ATOM   1113 H HH22 . ARG B 2 8  ? 1.863   1.170  -24.884 1.00 40.10 ? 1706 ARG E HH22 1 
ATOM   1114 N N    . LYS C 1 8  ? -4.096  40.035 -13.209 1.00 41.45 ? 1086 LYS B N    1 
ATOM   1115 C CA   . LYS C 1 8  ? -4.303  38.736 -12.576 1.00 41.24 ? 1086 LYS B CA   1 
ATOM   1116 C C    . LYS C 1 8  ? -4.830  37.625 -13.476 1.00 34.39 ? 1086 LYS B C    1 
ATOM   1117 O O    . LYS C 1 8  ? -4.383  36.475 -13.373 1.00 33.01 ? 1086 LYS B O    1 
ATOM   1118 C CB   . LYS C 1 8  ? -5.204  38.900 -11.355 1.00 52.59 ? 1086 LYS B CB   1 
ATOM   1119 C CG   . LYS C 1 8  ? -5.979  37.629 -10.973 1.00 65.23 ? 1086 LYS B CG   1 
ATOM   1120 C CD   . LYS C 1 8  ? -5.456  36.951 -9.701  1.00 63.24 ? 1086 LYS B CD   1 
ATOM   1121 C CE   . LYS C 1 8  ? -6.378  35.790 -9.266  1.00 68.46 ? 1086 LYS B CE   1 
ATOM   1122 N NZ   . LYS C 1 8  ? -6.620  34.790 -10.393 1.00 64.74 ? 1086 LYS B NZ   1 
ATOM   1123 H HA   . LYS C 1 8  ? -3.425  38.421 -12.312 1.00 49.64 ? 1086 LYS B HA   1 
ATOM   1124 H HB2  . LYS C 1 8  ? -4.655  39.150 -10.596 1.00 63.26 ? 1086 LYS B HB2  1 
ATOM   1125 H HB3  . LYS C 1 8  ? -5.853  39.597 -11.539 1.00 63.26 ? 1086 LYS B HB3  1 
ATOM   1126 H HG2  . LYS C 1 8  ? -6.909  37.862 -10.823 1.00 78.42 ? 1086 LYS B HG2  1 
ATOM   1127 H HG3  . LYS C 1 8  ? -5.911  36.989 -11.699 1.00 78.42 ? 1086 LYS B HG3  1 
ATOM   1128 H HD2  . LYS C 1 8  ? -4.571  36.592 -9.868  1.00 76.03 ? 1086 LYS B HD2  1 
ATOM   1129 H HD3  . LYS C 1 8  ? -5.421  37.600 -8.981  1.00 76.03 ? 1086 LYS B HD3  1 
ATOM   1130 H HE2  . LYS C 1 8  ? -5.965  35.316 -8.526  1.00 82.30 ? 1086 LYS B HE2  1 
ATOM   1131 H HE3  . LYS C 1 8  ? -7.236  36.150 -8.992  1.00 82.30 ? 1086 LYS B HE3  1 
ATOM   1132 H HZ1  . LYS C 1 8  ? -6.857  34.001 -10.055 1.00 77.83 ? 1086 LYS B HZ1  1 
ATOM   1133 H HZ2  . LYS C 1 8  ? -7.271  35.083 -10.925 1.00 77.83 ? 1086 LYS B HZ2  1 
ATOM   1134 H HZ3  . LYS C 1 8  ? -5.878  34.687 -10.873 1.00 77.83 ? 1086 LYS B HZ3  1 
ATOM   1135 N N    . VAL C 1 9  ? -5.874  37.936 -14.236 1.00 29.99 ? 1087 VAL B N    1 
ATOM   1136 C CA   . VAL C 1 9  ? -6.625  36.879 -14.904 1.00 22.19 ? 1087 VAL B CA   1 
ATOM   1137 C C    . VAL C 1 9  ? -5.786  36.271 -16.014 1.00 17.93 ? 1087 VAL B C    1 
ATOM   1138 O O    . VAL C 1 9  ? -5.233  36.976 -16.862 1.00 20.64 ? 1087 VAL B O    1 
ATOM   1139 C CB   . VAL C 1 9  ? -7.957  37.416 -15.455 1.00 26.34 ? 1087 VAL B CB   1 
ATOM   1140 C CG1  . VAL C 1 9  ? -8.755  36.302 -16.219 1.00 18.98 ? 1087 VAL B CG1  1 
ATOM   1141 C CG2  . VAL C 1 9  ? -8.783  37.984 -14.308 1.00 27.86 ? 1087 VAL B CG2  1 
ATOM   1142 H H    . VAL C 1 9  ? -6.162  38.733 -14.379 1.00 36.13 ? 1087 VAL B H    1 
ATOM   1143 H HA   . VAL C 1 9  ? -6.820  36.187 -14.253 1.00 26.78 ? 1087 VAL B HA   1 
ATOM   1144 H HB   . VAL C 1 9  ? -7.773  38.121 -16.096 1.00 31.75 ? 1087 VAL B HB   1 
ATOM   1145 H HG11 . VAL C 1 9  ? -9.653  36.622 -16.395 1.00 22.92 ? 1087 VAL B HG11 1 
ATOM   1146 H HG12 . VAL C 1 9  ? -8.303  36.108 -17.055 1.00 22.92 ? 1087 VAL B HG12 1 
ATOM   1147 H HG13 . VAL C 1 9  ? -8.789  35.505 -15.668 1.00 22.92 ? 1087 VAL B HG13 1 
ATOM   1148 H HG21 . VAL C 1 9  ? -9.682  38.166 -14.626 1.00 33.58 ? 1087 VAL B HG21 1 
ATOM   1149 H HG22 . VAL C 1 9  ? -8.812  37.335 -13.588 1.00 33.58 ? 1087 VAL B HG22 1 
ATOM   1150 H HG23 . VAL C 1 9  ? -8.370  38.805 -13.998 1.00 33.58 ? 1087 VAL B HG23 1 
ATOM   1151 N N    . ARG C 1 10 ? -5.727  34.950 -16.044 1.00 15.29 ? 1088 ARG B N    1 
ATOM   1152 C CA   . ARG C 1 10 ? -4.973  34.258 -17.075 1.00 16.03 ? 1088 ARG B CA   1 
ATOM   1153 C C    . ARG C 1 10 ? -5.835  33.368 -17.952 1.00 12.59 ? 1088 ARG B C    1 
ATOM   1154 O O    . ARG C 1 10 ? -5.570  33.272 -19.163 1.00 7.90  ? 1088 ARG B O    1 
ATOM   1155 C CB   . ARG C 1 10 ? -3.851  33.417 -16.442 1.00 16.62 ? 1088 ARG B CB   1 
ATOM   1156 C CG   . ARG C 1 10 ? -2.885  32.798 -17.453 1.00 16.87 ? 1088 ARG B CG   1 
ATOM   1157 C CD   . ARG C 1 10 ? -1.719  32.056 -16.759 1.00 14.94 ? 1088 ARG B CD   1 
ATOM   1158 N NE   . ARG C 1 10 ? -2.136  30.906 -15.953 1.00 14.63 ? 1088 ARG B NE   1 
ATOM   1159 C CZ   . ARG C 1 10 ? -2.219  29.660 -16.402 1.00 11.87 ? 1088 ARG B CZ   1 
ATOM   1160 N NH1  . ARG C 1 10 ? -1.886  29.348 -17.640 1.00 14.35 ? 1088 ARG B NH1  1 
ATOM   1161 N NH2  . ARG C 1 10 ? -2.640  28.704 -15.585 1.00 20.18 ? 1088 ARG B NH2  1 
ATOM   1162 H H    . ARG C 1 10 ? -6.116  34.432 -15.478 1.00 18.50 ? 1088 ARG B H    1 
ATOM   1163 H HA   . ARG C 1 10 ? -4.556  34.921 -17.648 1.00 19.38 ? 1088 ARG B HA   1 
ATOM   1164 H HB2  . ARG C 1 10 ? -3.334  33.985 -15.850 1.00 20.09 ? 1088 ARG B HB2  1 
ATOM   1165 H HB3  . ARG C 1 10 ? -4.254  32.693 -15.938 1.00 20.09 ? 1088 ARG B HB3  1 
ATOM   1166 H HG2  . ARG C 1 10 ? -3.364  32.160 -18.004 1.00 20.39 ? 1088 ARG B HG2  1 
ATOM   1167 H HG3  . ARG C 1 10 ? -2.510  33.499 -18.007 1.00 20.39 ? 1088 ARG B HG3  1 
ATOM   1168 H HD2  . ARG C 1 10 ? -1.108  31.733 -17.439 1.00 18.08 ? 1088 ARG B HD2  1 
ATOM   1169 H HD3  . ARG C 1 10 ? -1.262  32.677 -16.170 1.00 18.08 ? 1088 ARG B HD3  1 
ATOM   1170 H HE   . ARG C 1 10 ? -2.341  31.048 -15.131 1.00 17.71 ? 1088 ARG B HE   1 
ATOM   1171 H HH11 . ARG C 1 10 ? -1.607  29.958 -18.177 1.00 17.36 ? 1088 ARG B HH11 1 
ATOM   1172 H HH12 . ARG C 1 10 ? -1.948  28.533 -17.909 1.00 17.36 ? 1088 ARG B HH12 1 
ATOM   1173 H HH21 . ARG C 1 10 ? -2.856  28.895 -14.774 1.00 24.36 ? 1088 ARG B HH21 1 
ATOM   1174 H HH22 . ARG C 1 10 ? -2.698  27.894 -15.865 1.00 24.36 ? 1088 ARG B HH22 1 
ATOM   1175 N N    . ARG C 1 11 ? -6.809  32.664 -17.375 1.00 11.74 ? 1089 ARG B N    1 
ATOM   1176 C CA   . ARG C 1 11 ? -7.658  31.736 -18.107 1.00 13.95 ? 1089 ARG B CA   1 
ATOM   1177 C C    . ARG C 1 11 ? -9.113  32.090 -17.863 1.00 10.61 ? 1089 ARG B C    1 
ATOM   1178 O O    . ARG C 1 11 ? -9.522  32.365 -16.730 1.00 11.66 ? 1089 ARG B O    1 
ATOM   1179 C CB   . ARG C 1 11 ? -7.397  30.280 -17.717 1.00 12.17 ? 1089 ARG B CB   1 
ATOM   1180 C CG   . ARG C 1 11 ? -5.954  29.844 -17.848 1.00 16.85 ? 1089 ARG B CG   1 
ATOM   1181 C CD   . ARG C 1 11 ? -5.631  28.685 -16.907 1.00 28.14 ? 1089 ARG B CD   1 
ATOM   1182 N NE   . ARG C 1 11 ? -6.561  27.572 -17.045 1.00 30.85 ? 1089 ARG B NE   1 
ATOM   1183 C CZ   . ARG C 1 11 ? -6.710  26.890 -18.164 1.00 18.10 ? 1089 ARG B CZ   1 
ATOM   1184 N NH1  . ARG C 1 11 ? -6.015  27.192 -19.240 1.00 24.08 ? 1089 ARG B NH1  1 
ATOM   1185 N NH2  . ARG C 1 11 ? -7.566  25.874 -18.203 1.00 16.51 ? 1089 ARG B NH2  1 
ATOM   1186 H H    . ARG C 1 11 ? -6.999  32.712 -16.538 1.00 14.24 ? 1089 ARG B H    1 
ATOM   1187 H HA   . ARG C 1 11 ? -7.471  31.826 -19.055 1.00 16.88 ? 1089 ARG B HA   1 
ATOM   1188 H HB2  . ARG C 1 11 ? -7.657  30.157 -16.791 1.00 14.75 ? 1089 ARG B HB2  1 
ATOM   1189 H HB3  . ARG C 1 11 ? -7.929  29.707 -18.290 1.00 14.75 ? 1089 ARG B HB3  1 
ATOM   1190 H HG2  . ARG C 1 11 ? -5.788  29.553 -18.758 1.00 20.36 ? 1089 ARG B HG2  1 
ATOM   1191 H HG3  . ARG C 1 11 ? -5.372  30.588 -17.626 1.00 20.36 ? 1089 ARG B HG3  1 
ATOM   1192 H HD2  . ARG C 1 11 ? -4.740  28.357 -17.103 1.00 33.91 ? 1089 ARG B HD2  1 
ATOM   1193 H HD3  . ARG C 1 11 ? -5.674  29.000 -15.990 1.00 33.91 ? 1089 ARG B HD3  1 
ATOM   1194 H HE   . ARG C 1 11 ? -7.036  27.348 -16.363 1.00 37.17 ? 1089 ARG B HE   1 
ATOM   1195 H HH11 . ARG C 1 11 ? -5.453  27.843 -19.220 1.00 29.05 ? 1089 ARG B HH11 1 
ATOM   1196 H HH12 . ARG C 1 11 ? -6.123  26.739 -19.963 1.00 29.05 ? 1089 ARG B HH12 1 
ATOM   1197 H HH21 . ARG C 1 11 ? -8.018  25.666 -17.502 1.00 19.96 ? 1089 ARG B HH21 1 
ATOM   1198 H HH22 . ARG C 1 11 ? -7.668  25.426 -18.930 1.00 19.96 ? 1089 ARG B HH22 1 
ATOM   1199 N N    . VAL C 1 12 ? -9.885  32.121 -18.937 1.00 11.78 ? 1090 VAL B N    1 
ATOM   1200 C CA   . VAL C 1 12 ? -11.321 32.336 -18.867 1.00 8.37  ? 1090 VAL B CA   1 
ATOM   1201 C C    . VAL C 1 12 ? -11.963 31.250 -19.709 1.00 8.00  ? 1090 VAL B C    1 
ATOM   1202 O O    . VAL C 1 12 ? -11.315 30.594 -20.525 1.00 6.78  ? 1090 VAL B O    1 
ATOM   1203 C CB   . VAL C 1 12 ? -11.756 33.747 -19.325 1.00 8.04  ? 1090 VAL B CB   1 
ATOM   1204 C CG1  . VAL C 1 12 ? -11.165 34.774 -18.406 1.00 10.27 ? 1090 VAL B CG1  1 
ATOM   1205 C CG2  . VAL C 1 12 ? -11.332 34.037 -20.763 1.00 7.20  ? 1090 VAL B CG2  1 
ATOM   1206 H H    . VAL C 1 12 ? -9.593  32.016 -19.739 1.00 14.28 ? 1090 VAL B H    1 
ATOM   1207 H HA   . VAL C 1 12 ? -11.628 32.254 -17.950 1.00 10.19 ? 1090 VAL B HA   1 
ATOM   1208 H HB   . VAL C 1 12 ? -12.725 33.792 -19.295 1.00 9.80  ? 1090 VAL B HB   1 
ATOM   1209 H HG11 . VAL C 1 12 ? -11.372 35.659 -18.746 1.00 12.47 ? 1090 VAL B HG11 1 
ATOM   1210 H HG12 . VAL C 1 12 ? -11.545 34.663 -17.521 1.00 12.47 ? 1090 VAL B HG12 1 
ATOM   1211 H HG13 . VAL C 1 12 ? -10.203 34.650 -18.371 1.00 12.47 ? 1090 VAL B HG13 1 
ATOM   1212 H HG21 . VAL C 1 12 ? -11.548 34.959 -20.977 1.00 8.78  ? 1090 VAL B HG21 1 
ATOM   1213 H HG22 . VAL C 1 12 ? -10.376 33.895 -20.845 1.00 8.78  ? 1090 VAL B HG22 1 
ATOM   1214 H HG23 . VAL C 1 12 ? -11.808 33.439 -21.360 1.00 8.78  ? 1090 VAL B HG23 1 
ATOM   1215 N N    . LYS C 1 13 ? -13.241 31.020 -19.441 1.00 7.48  ? 1091 LYS B N    1 
ATOM   1216 C CA   . LYS C 1 13 ? -14.060 30.067 -20.163 1.00 8.35  ? 1091 LYS B CA   1 
ATOM   1217 C C    . LYS C 1 13 ? -15.199 30.852 -20.788 1.00 6.13  ? 1091 LYS B C    1 
ATOM   1218 O O    . LYS C 1 13 ? -15.879 31.615 -20.091 1.00 8.58  ? 1091 LYS B O    1 
ATOM   1219 C CB   . LYS C 1 13 ? -14.614 28.979 -19.231 1.00 13.51 ? 1091 LYS B CB   1 
ATOM   1220 C CG   . LYS C 1 13 ? -15.320 27.879 -20.004 1.00 14.15 ? 1091 LYS B CG   1 
ATOM   1221 C CD   . LYS C 1 13 ? -15.509 26.615 -19.193 1.00 24.37 ? 1091 LYS B CD   1 
ATOM   1222 C CE   . LYS C 1 13 ? -15.863 25.462 -20.135 1.00 31.64 ? 1091 LYS B CE   1 
ATOM   1223 N NZ   . LYS C 1 13 ? -15.556 24.096 -19.606 1.00 42.35 ? 1091 LYS B NZ   1 
ATOM   1224 H H    . LYS C 1 13 ? -13.672 31.425 -18.816 1.00 9.13  ? 1091 LYS B H    1 
ATOM   1225 H HA   . LYS C 1 13 ? -13.543 29.620 -20.851 1.00 10.17 ? 1091 LYS B HA   1 
ATOM   1226 H HB2  . LYS C 1 13 ? -13.882 28.581 -18.735 1.00 16.36 ? 1091 LYS B HB2  1 
ATOM   1227 H HB3  . LYS C 1 13 ? -15.251 29.378 -18.618 1.00 16.36 ? 1091 LYS B HB3  1 
ATOM   1228 H HG2  . LYS C 1 13 ? -16.197 28.195 -20.273 1.00 17.12 ? 1091 LYS B HG2  1 
ATOM   1229 H HG3  . LYS C 1 13 ? -14.794 27.655 -20.788 1.00 17.12 ? 1091 LYS B HG3  1 
ATOM   1230 H HD2  . LYS C 1 13 ? -14.687 26.397 -18.724 1.00 29.39 ? 1091 LYS B HD2  1 
ATOM   1231 H HD3  . LYS C 1 13 ? -16.231 26.735 -18.557 1.00 29.39 ? 1091 LYS B HD3  1 
ATOM   1232 H HE2  . LYS C 1 13 ? -16.815 25.495 -20.318 1.00 38.11 ? 1091 LYS B HE2  1 
ATOM   1233 H HE3  . LYS C 1 13 ? -15.363 25.573 -20.959 1.00 38.11 ? 1091 LYS B HE3  1 
ATOM   1234 H HZ1  . LYS C 1 13 ? -15.771 23.480 -20.211 1.00 50.97 ? 1091 LYS B HZ1  1 
ATOM   1235 H HZ2  . LYS C 1 13 ? -14.688 24.030 -19.421 1.00 50.97 ? 1091 LYS B HZ2  1 
ATOM   1236 H HZ3  . LYS C 1 13 ? -16.022 23.946 -18.863 1.00 50.97 ? 1091 LYS B HZ3  1 
ATOM   1237 N N    . THR C 1 14 ? -15.405 30.669 -22.087 1.00 4.87  ? 1092 THR B N    1 
ATOM   1238 C CA   . THR C 1 14 ? -16.437 31.407 -22.792 1.00 3.37  ? 1092 THR B CA   1 
ATOM   1239 C C    . THR C 1 14 ? -17.807 30.846 -22.438 1.00 5.89  ? 1092 THR B C    1 
ATOM   1240 O O    . THR C 1 14 ? -17.983 29.637 -22.287 1.00 5.07  ? 1092 THR B O    1 
ATOM   1241 C CB   . THR C 1 14 ? -16.254 31.323 -24.285 1.00 5.00  ? 1092 THR B CB   1 
ATOM   1242 O OG1  . THR C 1 14 ? -16.327 29.957 -24.699 1.00 7.75  ? 1092 THR B OG1  1 
ATOM   1243 C CG2  . THR C 1 14 ? -14.923 31.975 -24.710 1.00 4.90  ? 1092 THR B CG2  1 
ATOM   1244 H H    . THR C 1 14 ? -14.961 30.123 -22.581 1.00 5.99  ? 1092 THR B H    1 
ATOM   1245 H HA   . THR C 1 14 ? -16.382 32.340 -22.533 1.00 4.19  ? 1092 THR B HA   1 
ATOM   1246 H HB   . THR C 1 14 ? -16.959 31.811 -24.738 1.00 6.15  ? 1092 THR B HB   1 
ATOM   1247 H HG1  . THR C 1 14 ? -16.369 29.912 -25.536 1.00 9.45  ? 1092 THR B HG1  1 
ATOM   1248 H HG21 . THR C 1 14 ? -14.702 31.718 -25.618 1.00 6.03  ? 1092 THR B HG21 1 
ATOM   1249 H HG22 . THR C 1 14 ? -14.998 32.941 -24.665 1.00 6.03  ? 1092 THR B HG22 1 
ATOM   1250 H HG23 . THR C 1 14 ? -14.209 31.687 -24.119 1.00 6.03  ? 1092 THR B HG23 1 
ATOM   1251 N N    . ILE C 1 15 ? -18.777 31.735 -22.298 1.00 7.10  ? 1093 ILE B N    1 
ATOM   1252 C CA   . ILE C 1 15 ? -20.131 31.352 -21.920 1.00 11.68 ? 1093 ILE B CA   1 
ATOM   1253 C C    . ILE C 1 15 ? -21.164 31.690 -22.993 1.00 9.17  ? 1093 ILE B C    1 
ATOM   1254 O O    . ILE C 1 15 ? -22.328 31.268 -22.871 1.00 10.86 ? 1093 ILE B O    1 
ATOM   1255 C CB   . ILE C 1 15 ? -20.532 31.978 -20.566 1.00 8.97  ? 1093 ILE B CB   1 
ATOM   1256 C CG1  . ILE C 1 15 ? -20.280 33.479 -20.564 1.00 13.95 ? 1093 ILE B CG1  1 
ATOM   1257 C CG2  . ILE C 1 15 ? -19.677 31.416 -19.422 1.00 11.75 ? 1093 ILE B CG2  1 
ATOM   1258 C CD1  . ILE C 1 15 ? -20.979 34.207 -19.444 1.00 17.29 ? 1093 ILE B CD1  1 
ATOM   1259 H H    . ILE C 1 15 ? -18.677 32.581 -22.417 1.00 8.67  ? 1093 ILE B H    1 
ATOM   1260 H HA   . ILE C 1 15 ? -20.155 30.389 -21.808 1.00 14.16 ? 1093 ILE B HA   1 
ATOM   1261 H HB   . ILE C 1 15 ? -21.472 31.772 -20.444 1.00 10.91 ? 1093 ILE B HB   1 
ATOM   1262 H HG12 . ILE C 1 15 ? -19.327 33.635 -20.471 1.00 16.89 ? 1093 ILE B HG12 1 
ATOM   1263 H HG13 . ILE C 1 15 ? -20.597 33.850 -21.403 1.00 16.89 ? 1093 ILE B HG13 1 
ATOM   1264 H HG21 . ILE C 1 15 ? -20.028 31.738 -18.577 1.00 14.24 ? 1093 ILE B HG21 1 
ATOM   1265 H HG22 . ILE C 1 15 ? -19.713 30.447 -19.447 1.00 14.24 ? 1093 ILE B HG22 1 
ATOM   1266 H HG23 . ILE C 1 15 ? -18.761 31.715 -19.535 1.00 14.24 ? 1093 ILE B HG23 1 
ATOM   1267 H HD11 . ILE C 1 15 ? -20.841 35.161 -19.554 1.00 20.90 ? 1093 ILE B HD11 1 
ATOM   1268 H HD12 . ILE C 1 15 ? -21.926 34.004 -19.478 1.00 20.90 ? 1093 ILE B HD12 1 
ATOM   1269 H HD13 . ILE C 1 15 ? -20.607 33.915 -18.597 1.00 20.90 ? 1093 ILE B HD13 1 
ATOM   1270 N N    . TYR C 1 16 ? -20.773 32.406 -24.046 1.00 9.45  ? 1094 TYR B N    1 
ATOM   1271 C CA   . TYR C 1 16 ? -21.621 32.620 -25.210 1.00 9.43  ? 1094 TYR B CA   1 
ATOM   1272 C C    . TYR C 1 16 ? -20.761 32.361 -26.440 1.00 14.80 ? 1094 TYR B C    1 
ATOM   1273 O O    . TYR C 1 16 ? -19.521 32.348 -26.383 1.00 7.95  ? 1094 TYR B O    1 
ATOM   1274 C CB   . TYR C 1 16 ? -22.243 34.045 -25.281 1.00 11.26 ? 1094 TYR B CB   1 
ATOM   1275 C CG   . TYR C 1 16 ? -23.119 34.373 -24.097 1.00 8.59  ? 1094 TYR B CG   1 
ATOM   1276 C CD1  . TYR C 1 16 ? -24.310 33.699 -23.892 1.00 14.22 ? 1094 TYR B CD1  1 
ATOM   1277 C CD2  . TYR C 1 16 ? -22.749 35.338 -23.184 1.00 13.06 ? 1094 TYR B CD2  1 
ATOM   1278 C CE1  . TYR C 1 16 ? -25.110 33.957 -22.784 1.00 14.43 ? 1094 TYR B CE1  1 
ATOM   1279 C CE2  . TYR C 1 16 ? -23.518 35.590 -22.058 1.00 19.35 ? 1094 TYR B CE2  1 
ATOM   1280 C CZ   . TYR C 1 16 ? -24.708 34.901 -21.880 1.00 17.93 ? 1094 TYR B CZ   1 
ATOM   1281 O OH   . TYR C 1 16 ? -25.482 35.157 -20.784 1.00 22.32 ? 1094 TYR B OH   1 
ATOM   1282 H H    . TYR C 1 16 ? -20.004 32.785 -24.109 1.00 11.48 ? 1094 TYR B H    1 
ATOM   1283 H HA   . TYR C 1 16 ? -22.369 32.003 -25.181 1.00 11.46 ? 1094 TYR B HA   1 
ATOM   1284 H HB2  . TYR C 1 16 ? -21.527 34.699 -25.312 1.00 13.66 ? 1094 TYR B HB2  1 
ATOM   1285 H HB3  . TYR C 1 16 ? -22.787 34.110 -26.081 1.00 13.66 ? 1094 TYR B HB3  1 
ATOM   1286 H HD1  . TYR C 1 16 ? -24.583 33.060 -24.510 1.00 17.21 ? 1094 TYR B HD1  1 
ATOM   1287 H HD2  . TYR C 1 16 ? -21.971 35.828 -23.326 1.00 15.82 ? 1094 TYR B HD2  1 
ATOM   1288 H HE1  . TYR C 1 16 ? -25.907 33.494 -22.659 1.00 17.46 ? 1094 TYR B HE1  1 
ATOM   1289 H HE2  . TYR C 1 16 ? -23.239 36.214 -21.428 1.00 23.37 ? 1094 TYR B HE2  1 
ATOM   1290 H HH   . TYR C 1 16 ? -26.128 34.621 -20.757 1.00 26.94 ? 1094 TYR B HH   1 
ATOM   1291 N N    . ASP C 1 17 ? -21.452 32.114 -27.544 1.00 10.67 ? 1095 ASP B N    1 
ATOM   1292 C CA   . ASP C 1 17 ? -20.848 32.192 -28.860 1.00 9.79  ? 1095 ASP B CA   1 
ATOM   1293 C C    . ASP C 1 17 ? -20.508 33.645 -29.171 1.00 10.76 ? 1095 ASP B C    1 
ATOM   1294 O O    . ASP C 1 17 ? -21.150 34.566 -28.673 1.00 10.31 ? 1095 ASP B O    1 
ATOM   1295 C CB   . ASP C 1 17 ? -21.815 31.676 -29.911 1.00 7.39  ? 1095 ASP B CB   1 
ATOM   1296 C CG   . ASP C 1 17 ? -21.994 30.184 -29.868 1.00 11.93 ? 1095 ASP B CG   1 
ATOM   1297 O OD1  . ASP C 1 17 ? -21.379 29.505 -28.995 1.00 8.66  ? 1095 ASP B OD1  1 
ATOM   1298 O OD2  . ASP C 1 17 ? -22.758 29.687 -30.722 1.00 13.77 ? 1095 ASP B OD2  1 
ATOM   1299 H H    . ASP C 1 17 ? -22.283 31.896 -27.557 1.00 12.95 ? 1095 ASP B H    1 
ATOM   1300 H HA   . ASP C 1 17 ? -20.042 31.653 -28.890 1.00 11.89 ? 1095 ASP B HA   1 
ATOM   1301 H HB2  . ASP C 1 17 ? -22.683 32.085 -29.767 1.00 9.02  ? 1095 ASP B HB2  1 
ATOM   1302 H HB3  . ASP C 1 17 ? -21.479 31.911 -30.790 1.00 9.02  ? 1095 ASP B HB3  1 
ATOM   1303 N N    . CYS C 1 18 ? -19.511 33.856 -30.033 1.00 8.92  ? 1096 CYS B N    1 
ATOM   1304 C CA   . CYS C 1 18 ? -19.103 35.212 -30.402 1.00 12.32 ? 1096 CYS B CA   1 
ATOM   1305 C C    . CYS C 1 18 ? -18.477 35.193 -31.793 1.00 14.94 ? 1096 CYS B C    1 
ATOM   1306 O O    . CYS C 1 18 ? -17.522 34.452 -32.041 1.00 9.95  ? 1096 CYS B O    1 
ATOM   1307 C CB   . CYS C 1 18 ? -18.143 35.787 -29.379 1.00 12.45 ? 1096 CYS B CB   1 
ATOM   1308 S SG   . CYS C 1 18 ? -17.713 37.477 -29.717 1.00 10.10 ? 1096 CYS B SG   1 
ATOM   1309 H H    . CYS C 1 18 ? -19.058 33.234 -30.416 1.00 10.85 ? 1096 CYS B H    1 
ATOM   1310 H HA   . CYS C 1 18 ? -19.888 35.780 -30.443 1.00 14.93 ? 1096 CYS B HA   1 
ATOM   1311 H HB2  . CYS C 1 18 ? -18.557 35.751 -28.503 1.00 15.08 ? 1096 CYS B HB2  1 
ATOM   1312 H HB3  . CYS C 1 18 ? -17.327 35.263 -29.382 1.00 15.08 ? 1096 CYS B HB3  1 
ATOM   1313 H HG   . CYS C 1 18 ? -17.197 37.541 -30.798 1.00 12.27 ? 1096 CYS B HG   1 
ATOM   1314 N N    . GLN C 1 19 ? -19.041 35.974 -32.717 1.00 13.79 ? 1097 GLN B N    1 
ATOM   1315 C CA   . GLN C 1 19 ? -18.479 36.134 -34.060 1.00 11.64 ? 1097 GLN B CA   1 
ATOM   1316 C C    . GLN C 1 19 ? -17.821 37.502 -34.139 1.00 12.56 ? 1097 GLN B C    1 
ATOM   1317 O O    . GLN C 1 19 ? -18.422 38.518 -33.770 1.00 10.47 ? 1097 GLN B O    1 
ATOM   1318 C CB   . GLN C 1 19 ? -19.559 35.956 -35.131 1.00 16.56 ? 1097 GLN B CB   1 
ATOM   1319 C CG   . GLN C 1 19 ? -19.155 36.301 -36.572 1.00 22.72 ? 1097 GLN B CG   1 
ATOM   1320 C CD   . GLN C 1 19 ? -17.848 35.694 -37.044 1.00 32.61 ? 1097 GLN B CD   1 
ATOM   1321 O OE1  . GLN C 1 19 ? -16.796 36.343 -37.039 1.00 42.08 ? 1097 GLN B OE1  1 
ATOM   1322 N NE2  . GLN C 1 19 ? -17.914 34.431 -37.481 1.00 37.38 ? 1097 GLN B NE2  1 
ATOM   1323 H H    . GLN C 1 19 ? -19.760 36.427 -32.588 1.00 16.70 ? 1097 GLN B H    1 
ATOM   1324 H HA   . GLN C 1 19 ? -17.800 35.463 -34.234 1.00 14.11 ? 1097 GLN B HA   1 
ATOM   1325 H HB2  . GLN C 1 19 ? -19.836 35.026 -35.128 1.00 20.02 ? 1097 GLN B HB2  1 
ATOM   1326 H HB3  . GLN C 1 19 ? -20.309 36.526 -34.900 1.00 20.02 ? 1097 GLN B HB3  1 
ATOM   1327 H HG2  . GLN C 1 19 ? -19.852 35.986 -37.169 1.00 27.41 ? 1097 GLN B HG2  1 
ATOM   1328 H HG3  . GLN C 1 19 ? -19.069 37.265 -36.643 1.00 27.41 ? 1097 GLN B HG3  1 
ATOM   1329 H HE21 . GLN C 1 19 ? -18.667 34.015 -37.482 1.00 45.00 ? 1097 GLN B HE21 1 
ATOM   1330 H HE22 . GLN C 1 19 ? -17.204 34.035 -37.762 1.00 45.00 ? 1097 GLN B HE22 1 
ATOM   1331 N N    . ALA C 1 20 ? -16.565 37.523 -34.580 1.00 8.81  ? 1098 ALA B N    1 
ATOM   1332 C CA   . ALA C 1 20 ? -15.860 38.783 -34.669 1.00 9.43  ? 1098 ALA B CA   1 
ATOM   1333 C C    . ALA C 1 20 ? -16.576 39.753 -35.583 1.00 7.70  ? 1098 ALA B C    1 
ATOM   1334 O O    . ALA C 1 20 ? -17.076 39.377 -36.636 1.00 10.79 ? 1098 ALA B O    1 
ATOM   1335 C CB   . ALA C 1 20 ? -14.444 38.555 -35.189 1.00 13.66 ? 1098 ALA B CB   1 
ATOM   1336 H H    . ALA C 1 20 ? -16.115 36.833 -34.828 1.00 10.71 ? 1098 ALA B H    1 
ATOM   1337 H HA   . ALA C 1 20 ? -15.815 39.175 -33.782 1.00 11.47 ? 1098 ALA B HA   1 
ATOM   1338 H HB1  . ALA C 1 20 ? -14.026 39.415 -35.354 1.00 16.54 ? 1098 ALA B HB1  1 
ATOM   1339 H HB2  . ALA C 1 20 ? -13.938 38.064 -34.524 1.00 16.54 ? 1098 ALA B HB2  1 
ATOM   1340 H HB3  . ALA C 1 20 ? -14.489 38.046 -36.014 1.00 16.54 ? 1098 ALA B HB3  1 
ATOM   1341 N N    . ASP C 1 21 ? -16.613 41.008 -35.170 1.00 9.04  ? 1099 ASP B N    1 
ATOM   1342 C CA   . ASP C 1 21 ? -17.114 42.099 -35.981 1.00 9.07  ? 1099 ASP B CA   1 
ATOM   1343 C C    . ASP C 1 21 ? -16.002 42.873 -36.658 1.00 13.15 ? 1099 ASP B C    1 
ATOM   1344 O O    . ASP C 1 21 ? -16.266 43.617 -37.602 1.00 12.49 ? 1099 ASP B O    1 
ATOM   1345 C CB   . ASP C 1 21 ? -17.918 43.059 -35.127 1.00 9.46  ? 1099 ASP B CB   1 
ATOM   1346 C CG   . ASP C 1 21 ? -18.982 42.354 -34.310 1.00 12.26 ? 1099 ASP B CG   1 
ATOM   1347 O OD1  . ASP C 1 21 ? -19.786 41.632 -34.922 1.00 18.56 ? 1099 ASP B OD1  1 
ATOM   1348 O OD2  . ASP C 1 21 ? -18.973 42.530 -33.069 1.00 14.80 ? 1099 ASP B OD2  1 
ATOM   1349 H H    . ASP C 1 21 ? -16.343 41.263 -34.394 1.00 11.00 ? 1099 ASP B H    1 
ATOM   1350 H HA   . ASP C 1 21 ? -17.703 41.741 -36.664 1.00 11.02 ? 1099 ASP B HA   1 
ATOM   1351 H HB2  . ASP C 1 21 ? -17.320 43.515 -34.514 1.00 11.50 ? 1099 ASP B HB2  1 
ATOM   1352 H HB3  . ASP C 1 21 ? -18.358 43.703 -35.703 1.00 11.50 ? 1099 ASP B HB3  1 
ATOM   1353 N N    . ASN C 1 22 ? -14.781 42.722 -36.166 1.00 9.51  ? 1100 ASN B N    1 
ATOM   1354 C CA   . ASN C 1 22 ? -13.614 43.427 -36.657 1.00 8.72  ? 1100 ASN B CA   1 
ATOM   1355 C C    . ASN C 1 22 ? -12.477 42.442 -36.794 1.00 8.88  ? 1100 ASN B C    1 
ATOM   1356 O O    . ASN C 1 22 ? -12.491 41.358 -36.214 1.00 9.10  ? 1100 ASN B O    1 
ATOM   1357 C CB   . ASN C 1 22 ? -13.219 44.573 -35.726 1.00 10.14 ? 1100 ASN B CB   1 
ATOM   1358 C CG   . ASN C 1 22 ? -14.279 45.654 -35.664 1.00 18.17 ? 1100 ASN B CG   1 
ATOM   1359 O OD1  . ASN C 1 22 ? -14.398 46.453 -36.585 1.00 25.69 ? 1100 ASN B OD1  1 
ATOM   1360 N ND2  . ASN C 1 22 ? -15.053 45.684 -34.594 1.00 13.80 ? 1100 ASN B ND2  1 
ATOM   1361 H H    . ASN C 1 22 ? -14.597 42.190 -35.516 1.00 11.56 ? 1100 ASN B H    1 
ATOM   1362 H HA   . ASN C 1 22 ? -13.800 43.802 -37.532 1.00 10.61 ? 1100 ASN B HA   1 
ATOM   1363 H HB2  . ASN C 1 22 ? -13.090 44.224 -34.830 1.00 12.32 ? 1100 ASN B HB2  1 
ATOM   1364 H HB3  . ASN C 1 22 ? -12.396 44.975 -36.047 1.00 12.32 ? 1100 ASN B HB3  1 
ATOM   1365 H HD21 . ASN C 1 22 ? -15.666 46.283 -34.523 1.00 16.70 ? 1100 ASN B HD21 1 
ATOM   1366 H HD22 . ASN C 1 22 ? -14.943 45.105 -33.968 1.00 16.70 ? 1100 ASN B HD22 1 
ATOM   1367 N N    . ASP C 1 23 ? -11.489 42.837 -37.590 1.00 12.03 ? 1101 ASP B N    1 
ATOM   1368 C CA   . ASP C 1 23 ? -10.424 41.935 -37.971 1.00 11.69 ? 1101 ASP B CA   1 
ATOM   1369 C C    . ASP C 1 23 ? -9.401  41.728 -36.862 1.00 8.93  ? 1101 ASP B C    1 
ATOM   1370 O O    . ASP C 1 23 ? -8.459  40.967 -37.066 1.00 14.61 ? 1101 ASP B O    1 
ATOM   1371 C CB   . ASP C 1 23 ? -9.751  42.460 -39.254 1.00 10.42 ? 1101 ASP B CB   1 
ATOM   1372 C CG   . ASP C 1 23 ? -10.352 41.852 -40.530 1.00 10.28 ? 1101 ASP B CG   1 
ATOM   1373 O OD1  . ASP C 1 23 ? -10.963 40.763 -40.415 1.00 9.85  ? 1101 ASP B OD1  1 
ATOM   1374 O OD2  . ASP C 1 23 ? -10.193 42.461 -41.644 1.00 8.20  ? 1101 ASP B OD2  1 
ATOM   1375 H H    . ASP C 1 23 ? -11.418 43.628 -37.921 1.00 14.59 ? 1101 ASP B H    1 
ATOM   1376 H HA   . ASP C 1 23 ? -10.793 41.061 -38.174 1.00 14.18 ? 1101 ASP B HA   1 
ATOM   1377 H HB2  . ASP C 1 23 ? -9.863  43.422 -39.299 1.00 12.65 ? 1101 ASP B HB2  1 
ATOM   1378 H HB3  . ASP C 1 23 ? -8.808  42.236 -39.230 1.00 12.65 ? 1101 ASP B HB3  1 
ATOM   1379 N N    . ASP C 1 24 ? -9.546  42.352 -35.695 1.00 9.70  ? 1102 ASP B N    1 
ATOM   1380 C CA   . ASP C 1 24 ? -8.688  42.005 -34.563 1.00 9.84  ? 1102 ASP B CA   1 
ATOM   1381 C C    . ASP C 1 24 ? -9.431  41.228 -33.479 1.00 9.32  ? 1102 ASP B C    1 
ATOM   1382 O O    . ASP C 1 24 ? -8.855  40.962 -32.419 1.00 9.19  ? 1102 ASP B O    1 
ATOM   1383 C CB   . ASP C 1 24 ? -8.021  43.264 -33.977 1.00 9.12  ? 1102 ASP B CB   1 
ATOM   1384 C CG   . ASP C 1 24 ? -9.022  44.330 -33.533 1.00 10.48 ? 1102 ASP B CG   1 
ATOM   1385 O OD1  . ASP C 1 24 ? -10.219 44.209 -33.875 1.00 11.64 ? 1102 ASP B OD1  1 
ATOM   1386 O OD2  . ASP C 1 24 ? -8.592  45.308 -32.872 1.00 14.96 ? 1102 ASP B OD2  1 
ATOM   1387 H H    . ASP C 1 24 ? -10.124 42.969 -35.537 1.00 11.79 ? 1102 ASP B H    1 
ATOM   1388 H HA   . ASP C 1 24 ? -7.974  41.434 -34.888 1.00 11.96 ? 1102 ASP B HA   1 
ATOM   1389 H HB2  . ASP C 1 24 ? -7.496  43.009 -33.202 1.00 11.09 ? 1102 ASP B HB2  1 
ATOM   1390 H HB3  . ASP C 1 24 ? -7.446  43.659 -34.651 1.00 11.09 ? 1102 ASP B HB3  1 
ATOM   1391 N N    . GLU C 1 25 ? -10.678 40.835 -33.732 1.00 12.15 ? 1103 GLU B N    1 
ATOM   1392 C CA   . GLU C 1 25 ? -11.528 40.222 -32.733 1.00 4.27  ? 1103 GLU B CA   1 
ATOM   1393 C C    . GLU C 1 25 ? -11.526 38.718 -32.866 1.00 5.69  ? 1103 GLU B C    1 
ATOM   1394 O O    . GLU C 1 25 ? -11.481 38.167 -33.968 1.00 8.67  ? 1103 GLU B O    1 
ATOM   1395 C CB   . GLU C 1 25 ? -12.963 40.734 -32.835 1.00 6.00  ? 1103 GLU B CB   1 
ATOM   1396 C CG   . GLU C 1 25 ? -13.110 42.157 -32.313 1.00 8.14  ? 1103 GLU B CG   1 
ATOM   1397 C CD   . GLU C 1 25 ? -14.497 42.716 -32.541 1.00 11.26 ? 1103 GLU B CD   1 
ATOM   1398 O OE1  . GLU C 1 25 ? -15.405 41.926 -32.917 1.00 11.35 ? 1103 GLU B OE1  1 
ATOM   1399 O OE2  . GLU C 1 25 ? -14.687 43.938 -32.330 1.00 11.10 ? 1103 GLU B OE2  1 
ATOM   1400 H H    . GLU C 1 25 ? -11.059 40.919 -34.499 1.00 14.72 ? 1103 GLU B H    1 
ATOM   1401 H HA   . GLU C 1 25 ? -11.181 40.449 -31.856 1.00 5.27  ? 1103 GLU B HA   1 
ATOM   1402 H HB2  . GLU C 1 25 ? -13.237 40.724 -33.765 1.00 7.34  ? 1103 GLU B HB2  1 
ATOM   1403 H HB3  . GLU C 1 25 ? -13.542 40.159 -32.311 1.00 7.34  ? 1103 GLU B HB3  1 
ATOM   1404 H HG2  . GLU C 1 25 ? -12.936 42.164 -31.359 1.00 9.91  ? 1103 GLU B HG2  1 
ATOM   1405 H HG3  . GLU C 1 25 ? -12.476 42.730 -32.771 1.00 9.91  ? 1103 GLU B HG3  1 
ATOM   1406 N N    . LEU C 1 26 ? -11.632 38.060 -31.712 1.00 8.24  ? 1104 LEU B N    1 
ATOM   1407 C CA   . LEU C 1 26 ? -11.668 36.605 -31.637 1.00 7.53  ? 1104 LEU B CA   1 
ATOM   1408 C C    . LEU C 1 26 ? -13.080 36.062 -31.841 1.00 6.58  ? 1104 LEU B C    1 
ATOM   1409 O O    . LEU C 1 26 ? -14.041 36.541 -31.235 1.00 7.09  ? 1104 LEU B O    1 
ATOM   1410 C CB   . LEU C 1 26 ? -11.107 36.179 -30.273 1.00 4.15  ? 1104 LEU B CB   1 
ATOM   1411 C CG   . LEU C 1 26 ? -10.961 34.684 -30.022 1.00 7.24  ? 1104 LEU B CG   1 
ATOM   1412 C CD1  . LEU C 1 26 ? -9.971  33.995 -30.893 1.00 7.94  ? 1104 LEU B CD1  1 
ATOM   1413 C CD2  . LEU C 1 26 ? -10.622 34.454 -28.533 1.00 11.53 ? 1104 LEU B CD2  1 
ATOM   1414 H H    . LEU C 1 26 ? -11.686 38.443 -30.944 1.00 10.03 ? 1104 LEU B H    1 
ATOM   1415 H HA   . LEU C 1 26 ? -11.130 36.225 -32.349 1.00 9.18  ? 1104 LEU B HA   1 
ATOM   1416 H HB2  . LEU C 1 26 ? -10.225 36.570 -30.177 1.00 5.12  ? 1104 LEU B HB2  1 
ATOM   1417 H HB3  . LEU C 1 26 ? -11.699 36.524 -29.586 1.00 5.12  ? 1104 LEU B HB3  1 
ATOM   1418 H HG   . LEU C 1 26 ? -11.810 34.275 -30.250 1.00 8.84  ? 1104 LEU B HG   1 
ATOM   1419 H HD11 . LEU C 1 26 ? -10.069 33.036 -30.786 1.00 9.67  ? 1104 LEU B HD11 1 
ATOM   1420 H HD12 . LEU C 1 26 ? -10.135 34.244 -31.816 1.00 9.67  ? 1104 LEU B HD12 1 
ATOM   1421 H HD13 . LEU C 1 26 ? -9.077  34.267 -30.631 1.00 9.67  ? 1104 LEU B HD13 1 
ATOM   1422 H HD21 . LEU C 1 26 ? -10.461 33.508 -28.388 1.00 13.98 ? 1104 LEU B HD21 1 
ATOM   1423 H HD22 . LEU C 1 26 ? -9.827  34.963 -28.308 1.00 13.98 ? 1104 LEU B HD22 1 
ATOM   1424 H HD23 . LEU C 1 26 ? -11.369 34.749 -27.990 1.00 13.98 ? 1104 LEU B HD23 1 
ATOM   1425 N N    . THR C 1 27 ? -13.185 35.037 -32.676 1.00 11.62 ? 1105 THR B N    1 
ATOM   1426 C CA   . THR C 1 27 ? -14.412 34.291 -32.915 1.00 10.90 ? 1105 THR B CA   1 
ATOM   1427 C C    . THR C 1 27 ? -14.315 32.998 -32.138 1.00 9.59  ? 1105 THR B C    1 
ATOM   1428 O O    . THR C 1 27 ? -13.286 32.312 -32.199 1.00 7.40  ? 1105 THR B O    1 
ATOM   1429 C CB   . THR C 1 27 ? -14.589 34.001 -34.405 1.00 11.80 ? 1105 THR B CB   1 
ATOM   1430 O OG1  . THR C 1 27 ? -14.869 35.229 -35.055 1.00 11.04 ? 1105 THR B OG1  1 
ATOM   1431 C CG2  . THR C 1 27 ? -15.717 33.038 -34.648 1.00 16.23 ? 1105 THR B CG2  1 
ATOM   1432 H H    . THR C 1 27 ? -12.524 34.739 -33.139 1.00 14.09 ? 1105 THR B H    1 
ATOM   1433 H HA   . THR C 1 27 ? -15.186 34.795 -32.620 1.00 13.22 ? 1105 THR B HA   1 
ATOM   1434 H HB   . THR C 1 27 ? -13.785 33.595 -34.763 1.00 14.30 ? 1105 THR B HB   1 
ATOM   1435 H HG1  . THR C 1 27 ? -15.067 35.089 -35.860 1.00 13.39 ? 1105 THR B HG1  1 
ATOM   1436 H HG21 . THR C 1 27 ? -15.974 33.057 -35.583 1.00 19.63 ? 1105 THR B HG21 1 
ATOM   1437 H HG22 . THR C 1 27 ? -15.440 32.138 -34.416 1.00 19.63 ? 1105 THR B HG22 1 
ATOM   1438 H HG23 . THR C 1 27 ? -16.484 33.281 -34.106 1.00 19.63 ? 1105 THR B HG23 1 
ATOM   1439 N N    . PHE C 1 28 ? -15.371 32.674 -31.400 1.00 4.19  ? 1106 PHE B N    1 
ATOM   1440 C CA   . PHE C 1 28 ? -15.368 31.490 -30.575 1.00 7.25  ? 1106 PHE B CA   1 
ATOM   1441 C C    . PHE C 1 28 ? -16.796 31.011 -30.372 1.00 8.36  ? 1106 PHE B C    1 
ATOM   1442 O O    . PHE C 1 28 ? -17.755 31.727 -30.637 1.00 8.67  ? 1106 PHE B O    1 
ATOM   1443 C CB   . PHE C 1 28 ? -14.701 31.754 -29.211 1.00 4.02  ? 1106 PHE B CB   1 
ATOM   1444 C CG   . PHE C 1 28 ? -15.246 32.959 -28.445 1.00 4.48  ? 1106 PHE B CG   1 
ATOM   1445 C CD1  . PHE C 1 28 ? -16.312 32.821 -27.586 1.00 6.95  ? 1106 PHE B CD1  1 
ATOM   1446 C CD2  . PHE C 1 28 ? -14.669 34.219 -28.575 1.00 4.18  ? 1106 PHE B CD2  1 
ATOM   1447 C CE1  . PHE C 1 28 ? -16.781 33.899 -26.849 1.00 9.27  ? 1106 PHE B CE1  1 
ATOM   1448 C CE2  . PHE C 1 28 ? -15.143 35.316 -27.879 1.00 5.76  ? 1106 PHE B CE2  1 
ATOM   1449 C CZ   . PHE C 1 28 ? -16.194 35.174 -27.004 1.00 11.11 ? 1106 PHE B CZ   1 
ATOM   1450 H H    . PHE C 1 28 ? -16.099 33.130 -31.365 1.00 5.18  ? 1106 PHE B H    1 
ATOM   1451 H HA   . PHE C 1 28 ? -14.877 30.790 -31.033 1.00 8.85  ? 1106 PHE B HA   1 
ATOM   1452 H HB2  . PHE C 1 28 ? -14.828 30.972 -28.651 1.00 4.98  ? 1106 PHE B HB2  1 
ATOM   1453 H HB3  . PHE C 1 28 ? -13.754 31.907 -29.357 1.00 4.98  ? 1106 PHE B HB3  1 
ATOM   1454 H HD1  . PHE C 1 28 ? -16.724 31.992 -27.499 1.00 8.49  ? 1106 PHE B HD1  1 
ATOM   1455 H HD2  . PHE C 1 28 ? -13.944 34.327 -29.148 1.00 5.16  ? 1106 PHE B HD2  1 
ATOM   1456 H HE1  . PHE C 1 28 ? -17.484 33.782 -26.251 1.00 11.27 ? 1106 PHE B HE1  1 
ATOM   1457 H HE2  . PHE C 1 28 ? -14.750 36.150 -28.002 1.00 7.05  ? 1106 PHE B HE2  1 
ATOM   1458 H HZ   . PHE C 1 28 ? -16.512 35.904 -26.524 1.00 13.48 ? 1106 PHE B HZ   1 
ATOM   1459 N N    . ILE C 1 29 ? -16.917 29.778 -29.906 1.00 8.89  ? 1107 ILE B N    1 
ATOM   1460 C CA   . ILE C 1 29 ? -18.185 29.259 -29.420 1.00 9.49  ? 1107 ILE B CA   1 
ATOM   1461 C C    . ILE C 1 29 ? -18.095 29.185 -27.901 1.00 12.89 ? 1107 ILE B C    1 
ATOM   1462 O O    . ILE C 1 29 ? -17.018 29.303 -27.300 1.00 11.03 ? 1107 ILE B O    1 
ATOM   1463 C CB   . ILE C 1 29 ? -18.538 27.878 -30.018 1.00 8.43  ? 1107 ILE B CB   1 
ATOM   1464 C CG1  . ILE C 1 29 ? -17.394 26.892 -29.777 1.00 16.17 ? 1107 ILE B CG1  1 
ATOM   1465 C CG2  . ILE C 1 29 ? -18.777 27.959 -31.528 1.00 11.73 ? 1107 ILE B CG2  1 
ATOM   1466 C CD1  . ILE C 1 29 ? -17.758 25.474 -30.016 1.00 14.85 ? 1107 ILE B CD1  1 
ATOM   1467 H H    . ILE C 1 29 ? -16.270 29.214 -29.860 1.00 10.81 ? 1107 ILE B H    1 
ATOM   1468 H HA   . ILE C 1 29 ? -18.894 29.870 -29.675 1.00 11.54 ? 1107 ILE B HA   1 
ATOM   1469 H HB   . ILE C 1 29 ? -19.350 27.582 -29.579 1.00 10.26 ? 1107 ILE B HB   1 
ATOM   1470 H HG12 . ILE C 1 29 ? -16.662 27.113 -30.374 1.00 19.55 ? 1107 ILE B HG12 1 
ATOM   1471 H HG13 . ILE C 1 29 ? -17.105 26.971 -28.854 1.00 19.55 ? 1107 ILE B HG13 1 
ATOM   1472 H HG21 . ILE C 1 29 ? -19.106 27.102 -31.842 1.00 14.22 ? 1107 ILE B HG21 1 
ATOM   1473 H HG22 . ILE C 1 29 ? -19.433 28.651 -31.707 1.00 14.22 ? 1107 ILE B HG22 1 
ATOM   1474 H HG23 . ILE C 1 29 ? -17.941 28.174 -31.970 1.00 14.22 ? 1107 ILE B HG23 1 
ATOM   1475 H HD11 . ILE C 1 29 ? -17.020 24.908 -29.740 1.00 17.96 ? 1107 ILE B HD11 1 
ATOM   1476 H HD12 . ILE C 1 29 ? -18.550 25.260 -29.498 1.00 17.96 ? 1107 ILE B HD12 1 
ATOM   1477 H HD13 . ILE C 1 29 ? -17.936 25.349 -30.961 1.00 17.96 ? 1107 ILE B HD13 1 
ATOM   1478 N N    . GLU C 1 30 ? -19.252 28.987 -27.286 1.00 9.61  ? 1108 GLU B N    1 
ATOM   1479 C CA   . GLU C 1 30 ? -19.368 28.760 -25.863 1.00 7.96  ? 1108 GLU B CA   1 
ATOM   1480 C C    . GLU C 1 30 ? -18.581 27.519 -25.449 1.00 7.05  ? 1108 GLU B C    1 
ATOM   1481 O O    . GLU C 1 30 ? -18.370 26.603 -26.247 1.00 7.73  ? 1108 GLU B O    1 
ATOM   1482 C CB   . GLU C 1 30 ? -20.856 28.591 -25.536 1.00 11.10 ? 1108 GLU B CB   1 
ATOM   1483 C CG   . GLU C 1 30 ? -21.098 28.493 -24.112 1.00 8.71  ? 1108 GLU B CG   1 
ATOM   1484 C CD   . GLU C 1 30 ? -20.918 27.096 -23.582 1.00 11.04 ? 1108 GLU B CD   1 
ATOM   1485 O OE1  . GLU C 1 30 ? -20.642 26.147 -24.361 1.00 14.07 ? 1108 GLU B OE1  1 
ATOM   1486 O OE2  . GLU C 1 30 ? -21.158 26.927 -22.364 1.00 12.65 ? 1108 GLU B OE2  1 
ATOM   1487 H H    . GLU C 1 30 ? -20.013 28.981 -27.688 1.00 11.68 ? 1108 GLU B H    1 
ATOM   1488 H HA   . GLU C 1 30 ? -19.006 29.505 -25.359 1.00 9.70  ? 1108 GLU B HA   1 
ATOM   1489 H HB2  . GLU C 1 30 ? -21.344 29.358 -25.873 1.00 13.47 ? 1108 GLU B HB2  1 
ATOM   1490 H HB3  . GLU C 1 30 ? -21.183 27.779 -25.954 1.00 13.47 ? 1108 GLU B HB3  1 
ATOM   1491 H HG2  . GLU C 1 30 ? -20.475 29.073 -23.645 1.00 10.59 ? 1108 GLU B HG2  1 
ATOM   1492 H HG3  . GLU C 1 30 ? -22.010 28.768 -23.927 1.00 10.59 ? 1108 GLU B HG3  1 
ATOM   1493 N N    . GLY C 1 31 ? -18.114 27.507 -24.192 1.00 2.49  ? 1109 GLY B N    1 
ATOM   1494 C CA   . GLY C 1 31 ? -17.377 26.394 -23.645 1.00 6.35  ? 1109 GLY B CA   1 
ATOM   1495 C C    . GLY C 1 31 ? -15.877 26.380 -23.931 1.00 11.07 ? 1109 GLY B C    1 
ATOM   1496 O O    . GLY C 1 31 ? -15.205 25.423 -23.551 1.00 13.40 ? 1109 GLY B O    1 
ATOM   1497 H H    . GLY C 1 31 ? -18.221 28.153 -23.635 1.00 3.14  ? 1109 GLY B H    1 
ATOM   1498 H HA2  . GLY C 1 31 ? -17.490 26.396 -22.681 1.00 7.77  ? 1109 GLY B HA2  1 
ATOM   1499 H HA3  . GLY C 1 31 ? -17.750 25.573 -24.004 1.00 7.77  ? 1109 GLY B HA3  1 
ATOM   1500 N N    . GLU C 1 32 ? -15.326 27.373 -24.615 1.00 12.39 ? 1110 GLU B N    1 
ATOM   1501 C CA   . GLU C 1 32 ? -13.897 27.318 -24.944 1.00 8.54  ? 1110 GLU B CA   1 
ATOM   1502 C C    . GLU C 1 32 ? -13.073 28.074 -23.924 1.00 6.66  ? 1110 GLU B C    1 
ATOM   1503 O O    . GLU C 1 32 ? -13.485 29.112 -23.396 1.00 5.83  ? 1110 GLU B O    1 
ATOM   1504 C CB   . GLU C 1 32 ? -13.612 27.904 -26.322 1.00 10.46 ? 1110 GLU B CB   1 
ATOM   1505 C CG   . GLU C 1 32 ? -14.418 27.328 -27.450 1.00 10.55 ? 1110 GLU B CG   1 
ATOM   1506 C CD   . GLU C 1 32 ? -13.805 27.630 -28.803 1.00 11.45 ? 1110 GLU B CD   1 
ATOM   1507 O OE1  . GLU C 1 32 ? -12.770 27.017 -29.115 1.00 14.72 ? 1110 GLU B OE1  1 
ATOM   1508 O OE2  . GLU C 1 32 ? -14.364 28.465 -29.560 1.00 10.04 ? 1110 GLU B OE2  1 
ATOM   1509 H H    . GLU C 1 32 ? -15.741 28.072 -24.894 1.00 15.02 ? 1110 GLU B H    1 
ATOM   1510 H HA   . GLU C 1 32 ? -13.630 26.386 -24.942 1.00 10.39 ? 1110 GLU B HA   1 
ATOM   1511 H HB2  . GLU C 1 32 ? -13.795 28.856 -26.292 1.00 12.70 ? 1110 GLU B HB2  1 
ATOM   1512 H HB3  . GLU C 1 32 ? -12.676 27.753 -26.529 1.00 12.70 ? 1110 GLU B HB3  1 
ATOM   1513 H HG2  . GLU C 1 32 ? -14.466 26.365 -27.348 1.00 12.80 ? 1110 GLU B HG2  1 
ATOM   1514 H HG3  . GLU C 1 32 ? -15.310 27.709 -27.431 1.00 12.80 ? 1110 GLU B HG3  1 
ATOM   1515 N N    . VAL C 1 33 ? -11.860 27.606 -23.722 1.00 14.00 ? 1111 VAL B N    1 
ATOM   1516 C CA   . VAL C 1 33 ? -10.931 28.266 -22.811 1.00 13.05 ? 1111 VAL B CA   1 
ATOM   1517 C C    . VAL C 1 33 ? -10.060 29.240 -23.586 1.00 4.58  ? 1111 VAL B C    1 
ATOM   1518 O O    . VAL C 1 33 ? -9.484  28.905 -24.635 1.00 6.32  ? 1111 VAL B O    1 
ATOM   1519 C CB   . VAL C 1 33 ? -10.086 27.230 -22.035 1.00 10.69 ? 1111 VAL B CB   1 
ATOM   1520 C CG1  . VAL C 1 33 ? -8.997  27.903 -21.179 1.00 14.25 ? 1111 VAL B CG1  1 
ATOM   1521 C CG2  . VAL C 1 33 ? -10.984 26.355 -21.175 1.00 9.85  ? 1111 VAL B CG2  1 
ATOM   1522 H H    . VAL C 1 33 ? -11.542 26.903 -24.102 1.00 16.95 ? 1111 VAL B H    1 
ATOM   1523 H HA   . VAL C 1 33 ? -11.437 28.784 -22.165 1.00 15.81 ? 1111 VAL B HA   1 
ATOM   1524 H HB   . VAL C 1 33 ? -9.631  26.668 -22.681 1.00 12.98 ? 1111 VAL B HB   1 
ATOM   1525 H HG11 . VAL C 1 33 ? -8.674  27.266 -20.522 1.00 17.24 ? 1111 VAL B HG11 1 
ATOM   1526 H HG12 . VAL C 1 33 ? -8.268  28.180 -21.756 1.00 17.24 ? 1111 VAL B HG12 1 
ATOM   1527 H HG13 . VAL C 1 33 ? -9.378  28.675 -20.733 1.00 17.24 ? 1111 VAL B HG13 1 
ATOM   1528 H HG21 . VAL C 1 33 ? -10.432 25.746 -20.660 1.00 11.96 ? 1111 VAL B HG21 1 
ATOM   1529 H HG22 . VAL C 1 33 ? -11.498 26.921 -20.578 1.00 11.96 ? 1111 VAL B HG22 1 
ATOM   1530 H HG23 . VAL C 1 33 ? -11.582 25.854 -21.751 1.00 11.96 ? 1111 VAL B HG23 1 
ATOM   1531 N N    . ILE C 1 34 ? -9.986  30.466 -23.073 1.00 6.77  ? 1112 ILE B N    1 
ATOM   1532 C CA   . ILE C 1 34 ? -9.126  31.512 -23.603 1.00 5.28  ? 1112 ILE B CA   1 
ATOM   1533 C C    . ILE C 1 34 ? -8.009  31.782 -22.604 1.00 5.66  ? 1112 ILE B C    1 
ATOM   1534 O O    . ILE C 1 34 ? -8.264  31.951 -21.412 1.00 6.96  ? 1112 ILE B O    1 
ATOM   1535 C CB   . ILE C 1 34 ? -9.916  32.797 -23.883 1.00 5.82  ? 1112 ILE B CB   1 
ATOM   1536 C CG1  . ILE C 1 34 ? -10.990 32.504 -24.946 1.00 5.15  ? 1112 ILE B CG1  1 
ATOM   1537 C CG2  . ILE C 1 34 ? -8.976  33.923 -24.285 1.00 5.89  ? 1112 ILE B CG2  1 
ATOM   1538 C CD1  . ILE C 1 34 ? -11.913 33.652 -25.193 1.00 7.80  ? 1112 ILE B CD1  1 
ATOM   1539 H H    . ILE C 1 34 ? -10.443 30.722 -22.392 1.00 8.26  ? 1112 ILE B H    1 
ATOM   1540 H HA   . ILE C 1 34 ? -8.728  31.200 -24.431 1.00 6.48  ? 1112 ILE B HA   1 
ATOM   1541 H HB   . ILE C 1 34 ? -10.369 33.094 -23.078 1.00 7.13  ? 1112 ILE B HB   1 
ATOM   1542 H HG12 . ILE C 1 34 ? -10.550 32.291 -25.784 1.00 6.32  ? 1112 ILE B HG12 1 
ATOM   1543 H HG13 . ILE C 1 34 ? -11.525 31.751 -24.652 1.00 6.32  ? 1112 ILE B HG13 1 
ATOM   1544 H HG21 . ILE C 1 34 ? -9.499  34.663 -24.631 1.00 7.21  ? 1112 ILE B HG21 1 
ATOM   1545 H HG22 . ILE C 1 34 ? -8.473  34.208 -23.506 1.00 7.21  ? 1112 ILE B HG22 1 
ATOM   1546 H HG23 . ILE C 1 34 ? -8.369  33.598 -24.969 1.00 7.21  ? 1112 ILE B HG23 1 
ATOM   1547 H HD11 . ILE C 1 34 ? -12.676 33.340 -25.703 1.00 9.51  ? 1112 ILE B HD11 1 
ATOM   1548 H HD12 . ILE C 1 34 ? -12.208 34.009 -24.340 1.00 9.51  ? 1112 ILE B HD12 1 
ATOM   1549 H HD13 . ILE C 1 34 ? -11.440 34.337 -25.691 1.00 9.51  ? 1112 ILE B HD13 1 
ATOM   1550 N N    . ILE C 1 35 ? -6.789  31.882 -23.112 1.00 9.77  ? 1113 ILE B N    1 
ATOM   1551 C CA   . ILE C 1 35 ? -5.646  32.419 -22.387 1.00 6.39  ? 1113 ILE B CA   1 
ATOM   1552 C C    . ILE C 1 35 ? -5.631  33.929 -22.570 1.00 6.87  ? 1113 ILE B C    1 
ATOM   1553 O O    . ILE C 1 35 ? -5.475  34.424 -23.697 1.00 8.96  ? 1113 ILE B O    1 
ATOM   1554 C CB   . ILE C 1 35 ? -4.330  31.806 -22.906 1.00 6.17  ? 1113 ILE B CB   1 
ATOM   1555 C CG1  . ILE C 1 35 ? -4.377  30.273 -22.897 1.00 7.75  ? 1113 ILE B CG1  1 
ATOM   1556 C CG2  . ILE C 1 35 ? -3.150  32.374 -22.119 1.00 8.82  ? 1113 ILE B CG2  1 
ATOM   1557 C CD1  . ILE C 1 35 ? -4.772  29.682 -21.537 1.00 12.62 ? 1113 ILE B CD1  1 
ATOM   1558 H H    . ILE C 1 35 ? -6.588  31.635 -23.911 1.00 11.87 ? 1113 ILE B H    1 
ATOM   1559 H HA   . ILE C 1 35 ? -5.740  32.216 -21.443 1.00 7.81  ? 1113 ILE B HA   1 
ATOM   1560 H HB   . ILE C 1 35 ? -4.212  32.057 -23.835 1.00 7.55  ? 1113 ILE B HB   1 
ATOM   1561 H HG12 . ILE C 1 35 ? -5.029  29.976 -23.550 1.00 9.45  ? 1113 ILE B HG12 1 
ATOM   1562 H HG13 . ILE C 1 35 ? -3.499  29.931 -23.126 1.00 9.45  ? 1113 ILE B HG13 1 
ATOM   1563 H HG21 . ILE C 1 35 ? -2.349  31.878 -22.350 1.00 10.73 ? 1113 ILE B HG21 1 
ATOM   1564 H HG22 . ILE C 1 35 ? -3.037  33.309 -22.350 1.00 10.73 ? 1113 ILE B HG22 1 
ATOM   1565 H HG23 . ILE C 1 35 ? -3.331  32.287 -21.171 1.00 10.73 ? 1113 ILE B HG23 1 
ATOM   1566 H HD11 . ILE C 1 35 ? -4.660  28.719 -21.566 1.00 15.29 ? 1113 ILE B HD11 1 
ATOM   1567 H HD12 . ILE C 1 35 ? -4.201  30.061 -20.850 1.00 15.29 ? 1113 ILE B HD12 1 
ATOM   1568 H HD13 . ILE C 1 35 ? -5.699  29.902 -21.354 1.00 15.29 ? 1113 ILE B HD13 1 
ATOM   1569 N N    . VAL C 1 36 ? -5.732  34.662 -21.471 1.00 6.84  ? 1114 VAL B N    1 
ATOM   1570 C CA   . VAL C 1 36 ? -5.766  36.118 -21.499 1.00 6.97  ? 1114 VAL B CA   1 
ATOM   1571 C C    . VAL C 1 36 ? -4.333  36.621 -21.519 1.00 9.84  ? 1114 VAL B C    1 
ATOM   1572 O O    . VAL C 1 36 ? -3.554  36.316 -20.615 1.00 9.16  ? 1114 VAL B O    1 
ATOM   1573 C CB   . VAL C 1 36 ? -6.527  36.670 -20.290 1.00 7.26  ? 1114 VAL B CB   1 
ATOM   1574 C CG1  . VAL C 1 36 ? -6.576  38.186 -20.321 1.00 10.34 ? 1114 VAL B CG1  1 
ATOM   1575 C CG2  . VAL C 1 36 ? -7.890  36.064 -20.270 1.00 10.16 ? 1114 VAL B CG2  1 
ATOM   1576 H H    . VAL C 1 36 ? -5.783  34.332 -20.678 1.00 8.35  ? 1114 VAL B H    1 
ATOM   1577 H HA   . VAL C 1 36 ? -6.212  36.420 -22.306 1.00 8.51  ? 1114 VAL B HA   1 
ATOM   1578 H HB   . VAL C 1 36 ? -6.070  36.435 -19.468 1.00 8.86  ? 1114 VAL B HB   1 
ATOM   1579 H HG11 . VAL C 1 36 ? -7.171  38.497 -19.621 1.00 12.55 ? 1114 VAL B HG11 1 
ATOM   1580 H HG12 . VAL C 1 36 ? -5.683  38.533 -20.174 1.00 12.55 ? 1114 VAL B HG12 1 
ATOM   1581 H HG13 . VAL C 1 36 ? -6.905  38.474 -21.187 1.00 12.55 ? 1114 VAL B HG13 1 
ATOM   1582 H HG21 . VAL C 1 36 ? -8.414  36.488 -19.573 1.00 12.34 ? 1114 VAL B HG21 1 
ATOM   1583 H HG22 . VAL C 1 36 ? -8.311  36.205 -21.132 1.00 12.34 ? 1114 VAL B HG22 1 
ATOM   1584 H HG23 . VAL C 1 36 ? -7.810  35.114 -20.093 1.00 12.34 ? 1114 VAL B HG23 1 
ATOM   1585 N N    . THR C 1 37 ? -3.978  37.377 -22.557 1.00 7.32  ? 1115 THR B N    1 
ATOM   1586 C CA   . THR C 1 37 ? -2.628  37.877 -22.742 1.00 10.64 ? 1115 THR B CA   1 
ATOM   1587 C C    . THR C 1 37 ? -2.573  39.390 -22.781 1.00 15.78 ? 1115 THR B C    1 
ATOM   1588 O O    . THR C 1 37 ? -1.492  39.947 -22.965 1.00 15.65 ? 1115 THR B O    1 
ATOM   1589 C CB   . THR C 1 37 ? -2.026  37.322 -24.032 1.00 4.86  ? 1115 THR B CB   1 
ATOM   1590 O OG1  . THR C 1 37 ? -2.846  37.712 -25.155 1.00 9.05  ? 1115 THR B OG1  1 
ATOM   1591 C CG2  . THR C 1 37 ? -1.897  35.806 -23.990 1.00 8.71  ? 1115 THR B CG2  1 
ATOM   1592 H H    . THR C 1 37 ? -4.520  37.617 -23.180 1.00 8.93  ? 1115 THR B H    1 
ATOM   1593 H HA   . THR C 1 37 ? -2.078  37.568 -22.005 1.00 12.92 ? 1115 THR B HA   1 
ATOM   1594 H HB   . THR C 1 37 ? -1.132  37.684 -24.140 1.00 5.97  ? 1115 THR B HB   1 
ATOM   1595 H HG1  . THR C 1 37 ? -2.823  38.546 -25.253 1.00 11.00 ? 1115 THR B HG1  1 
ATOM   1596 H HG21 . THR C 1 37 ? -1.455  35.489 -24.793 1.00 10.60 ? 1115 THR B HG21 1 
ATOM   1597 H HG22 . THR C 1 37 ? -1.375  35.539 -23.217 1.00 10.60 ? 1115 THR B HG22 1 
ATOM   1598 H HG23 . THR C 1 37 ? -2.776  35.400 -23.932 1.00 10.60 ? 1115 THR B HG23 1 
ATOM   1599 N N    . GLY C 1 38 ? -3.708  40.064 -22.631 1.00 20.52 ? 1116 GLY B N    1 
ATOM   1600 C CA   . GLY C 1 38 ? -3.742  41.511 -22.720 1.00 17.05 ? 1116 GLY B CA   1 
ATOM   1601 C C    . GLY C 1 38 ? -5.123  42.044 -22.415 1.00 15.77 ? 1116 GLY B C    1 
ATOM   1602 O O    . GLY C 1 38 ? -6.101  41.298 -22.304 1.00 9.51  ? 1116 GLY B O    1 
ATOM   1603 H H    . GLY C 1 38 ? -4.472  39.702 -22.475 1.00 24.78 ? 1116 GLY B H    1 
ATOM   1604 H HA2  . GLY C 1 38 ? -3.115  41.892 -22.086 1.00 20.61 ? 1116 GLY B HA2  1 
ATOM   1605 H HA3  . GLY C 1 38 ? -3.493  41.788 -23.616 1.00 20.61 ? 1116 GLY B HA3  1 
ATOM   1606 N N    . GLU C 1 39 ? -5.192  43.366 -22.310 1.00 14.73 ? 1117 GLU B N    1 
ATOM   1607 C CA   . GLU C 1 39 ? -6.436  44.071 -22.051 1.00 15.62 ? 1117 GLU B CA   1 
ATOM   1608 C C    . GLU C 1 39 ? -6.509  45.279 -22.974 1.00 12.52 ? 1117 GLU B C    1 
ATOM   1609 O O    . GLU C 1 39 ? -5.518  45.990 -23.163 1.00 16.12 ? 1117 GLU B O    1 
ATOM   1610 C CB   . GLU C 1 39 ? -6.537  44.477 -20.577 1.00 18.65 ? 1117 GLU B CB   1 
ATOM   1611 C CG   . GLU C 1 39 ? -6.765  43.288 -19.659 1.00 33.41 ? 1117 GLU B CG   1 
ATOM   1612 C CD   . GLU C 1 39 ? -5.725  43.155 -18.541 1.00 53.07 ? 1117 GLU B CD   1 
ATOM   1613 O OE1  . GLU C 1 39 ? -4.901  44.107 -18.359 1.00 54.66 ? 1117 GLU B OE1  1 
ATOM   1614 O OE2  . GLU C 1 39 ? -5.711  42.092 -17.882 1.00 52.83 ? 1117 GLU B OE2  1 
ATOM   1615 H H    . GLU C 1 39 ? -4.513  43.888 -22.388 1.00 17.83 ? 1117 GLU B H    1 
ATOM   1616 H HA   . GLU C 1 39 ? -7.198  43.505 -22.249 1.00 18.89 ? 1117 GLU B HA   1 
ATOM   1617 H HB2  . GLU C 1 39 ? -5.711  44.910 -20.310 1.00 22.52 ? 1117 GLU B HB2  1 
ATOM   1618 H HB3  . GLU C 1 39 ? -7.282  45.089 -20.467 1.00 22.52 ? 1117 GLU B HB3  1 
ATOM   1619 H HG2  . GLU C 1 39 ? -7.636  43.379 -19.242 1.00 40.24 ? 1117 GLU B HG2  1 
ATOM   1620 H HG3  . GLU C 1 39 ? -6.734  42.476 -20.188 1.00 40.24 ? 1117 GLU B HG3  1 
ATOM   1621 N N    . GLU C 1 40 ? -7.658  45.472 -23.604 1.00 14.36 ? 1118 GLU B N    1 
ATOM   1622 C CA   . GLU C 1 40 ? -7.921  46.738 -24.283 1.00 11.81 ? 1118 GLU B CA   1 
ATOM   1623 C C    . GLU C 1 40 ? -8.609  47.724 -23.351 1.00 13.40 ? 1118 GLU B C    1 
ATOM   1624 O O    . GLU C 1 40 ? -8.145  48.848 -23.143 1.00 12.58 ? 1118 GLU B O    1 
ATOM   1625 C CB   . GLU C 1 40 ? -8.767  46.489 -25.509 1.00 11.83 ? 1118 GLU B CB   1 
ATOM   1626 C CG   . GLU C 1 40 ? -9.411  47.724 -26.067 1.00 16.49 ? 1118 GLU B CG   1 
ATOM   1627 C CD   . GLU C 1 40 ? -9.978  47.478 -27.441 1.00 12.94 ? 1118 GLU B CD   1 
ATOM   1628 O OE1  . GLU C 1 40 ? -9.191  47.222 -28.382 1.00 15.41 ? 1118 GLU B OE1  1 
ATOM   1629 O OE2  . GLU C 1 40 ? -11.210 47.523 -27.584 1.00 14.36 ? 1118 GLU B OE2  1 
ATOM   1630 H H    . GLU C 1 40 ? -8.295  44.895 -23.653 1.00 17.38 ? 1118 GLU B H    1 
ATOM   1631 H HA   . GLU C 1 40 ? -7.084  47.131 -24.576 1.00 14.32 ? 1118 GLU B HA   1 
ATOM   1632 H HB2  . GLU C 1 40 ? -8.205  46.110 -26.203 1.00 14.34 ? 1118 GLU B HB2  1 
ATOM   1633 H HB3  . GLU C 1 40 ? -9.474  45.866 -25.278 1.00 14.34 ? 1118 GLU B HB3  1 
ATOM   1634 H HG2  . GLU C 1 40 ? -10.134 48.001 -25.483 1.00 19.94 ? 1118 GLU B HG2  1 
ATOM   1635 H HG3  . GLU C 1 40 ? -8.749  48.430 -26.131 1.00 19.94 ? 1118 GLU B HG3  1 
ATOM   1636 N N    . ASP C 1 41 ? -9.676  47.285 -22.703 1.00 12.61 ? 1119 ASP B N    1 
ATOM   1637 C CA   . ASP C 1 41 ? -10.262 48.102 -21.645 1.00 13.66 ? 1119 ASP B CA   1 
ATOM   1638 C C    . ASP C 1 41 ? -11.047 47.169 -20.689 1.00 16.99 ? 1119 ASP B C    1 
ATOM   1639 O O    . ASP C 1 41 ? -10.942 45.949 -20.819 1.00 14.91 ? 1119 ASP B O    1 
ATOM   1640 C CB   . ASP C 1 41 ? -11.104 49.246 -22.244 1.00 14.89 ? 1119 ASP B CB   1 
ATOM   1641 C CG   . ASP C 1 41 ? -12.343 48.772 -23.013 1.00 13.24 ? 1119 ASP B CG   1 
ATOM   1642 O OD1  . ASP C 1 41 ? -12.847 47.658 -22.773 1.00 12.63 ? 1119 ASP B OD1  1 
ATOM   1643 O OD2  . ASP C 1 41 ? -12.835 49.572 -23.838 1.00 15.94 ? 1119 ASP B OD2  1 
ATOM   1644 H H    . ASP C 1 41 ? -10.072 46.536 -22.852 1.00 15.28 ? 1119 ASP B H    1 
ATOM   1645 H HA   . ASP C 1 41 ? -9.546  48.508 -21.133 1.00 16.53 ? 1119 ASP B HA   1 
ATOM   1646 H HB2  . ASP C 1 41 ? -11.407 49.821 -21.524 1.00 18.02 ? 1119 ASP B HB2  1 
ATOM   1647 H HB3  . ASP C 1 41 ? -10.551 49.751 -22.860 1.00 18.02 ? 1119 ASP B HB3  1 
ATOM   1648 N N    . GLN C 1 42 ? -11.900 47.710 -19.807 1.00 15.72 ? 1120 GLN B N    1 
ATOM   1649 C CA   . GLN C 1 42 ? -12.638 46.920 -18.830 1.00 26.84 ? 1120 GLN B CA   1 
ATOM   1650 C C    . GLN C 1 42 ? -13.695 45.999 -19.515 1.00 16.84 ? 1120 GLN B C    1 
ATOM   1651 O O    . GLN C 1 42 ? -14.007 44.934 -18.983 1.00 16.43 ? 1120 GLN B O    1 
ATOM   1652 C CB   . GLN C 1 42 ? -13.234 47.935 -17.884 1.00 29.85 ? 1120 GLN B CB   1 
ATOM   1653 C CG   . GLN C 1 42 ? -11.835 48.388 -17.184 1.00 44.16 ? 1120 GLN B CG   1 
ATOM   1654 C CD   . GLN C 1 42 ? -12.013 49.306 -15.993 1.00 60.45 ? 1120 GLN B CD   1 
ATOM   1655 O OE1  . GLN C 1 42 ? -11.725 50.531 -16.130 1.00 56.97 ? 1120 GLN B OE1  1 
ATOM   1656 N NE2  . GLN C 1 42 ? -12.714 48.756 -14.932 1.00 61.55 ? 1120 GLN B NE2  1 
ATOM   1657 H H    . GLN C 1 42 ? -12.068 48.552 -19.758 1.00 19.01 ? 1120 GLN B H    1 
ATOM   1658 H HA   . GLN C 1 42 ? -12.090 46.306 -18.317 1.00 32.35 ? 1120 GLN B HA   1 
ATOM   1659 H HB2  . GLN C 1 42 ? -13.665 48.670 -18.346 1.00 35.97 ? 1120 GLN B HB2  1 
ATOM   1660 H HB3  . GLN C 1 42 ? -13.848 47.537 -17.247 1.00 35.97 ? 1120 GLN B HB3  1 
ATOM   1661 H HG2  . GLN C 1 42 ? -11.369 47.594 -16.878 1.00 53.14 ? 1120 GLN B HG2  1 
ATOM   1662 H HG3  . GLN C 1 42 ? -11.296 48.857 -17.840 1.00 53.14 ? 1120 GLN B HG3  1 
ATOM   1663 H HE21 . GLN C 1 42 ? -13.011 47.951 -14.983 1.00 74.01 ? 1120 GLN B HE21 1 
ATOM   1664 H HE22 . GLN C 1 42 ? -12.853 49.221 -14.221 1.00 74.01 ? 1120 GLN B HE22 1 
ATOM   1665 N N    . GLU C 1 43 ? -14.113 46.241 -20.787 1.00 11.75 ? 1121 GLU B N    1 
ATOM   1666 C CA   . GLU C 1 43 ? -15.063 45.343 -21.415 1.00 14.34 ? 1121 GLU B CA   1 
ATOM   1667 C C    . GLU C 1 43 ? -14.423 44.431 -22.440 1.00 10.43 ? 1121 GLU B C    1 
ATOM   1668 O O    . GLU C 1 43 ? -15.091 43.514 -22.921 1.00 9.70  ? 1121 GLU B O    1 
ATOM   1669 C CB   . GLU C 1 43 ? -16.134 46.173 -22.054 1.00 12.54 ? 1121 GLU B CB   1 
ATOM   1670 C CG   . GLU C 1 43 ? -16.954 46.944 -21.064 1.00 17.42 ? 1121 GLU B CG   1 
ATOM   1671 C CD   . GLU C 1 43 ? -17.774 46.028 -20.195 1.00 21.51 ? 1121 GLU B CD   1 
ATOM   1672 O OE1  . GLU C 1 43 ? -17.968 44.856 -20.567 1.00 25.92 ? 1121 GLU B OE1  1 
ATOM   1673 O OE2  . GLU C 1 43 ? -18.258 46.494 -19.145 1.00 27.54 ? 1121 GLU B OE2  1 
ATOM   1674 H H    . GLU C 1 43 ? -13.858 46.902 -21.273 1.00 14.25 ? 1121 GLU B H    1 
ATOM   1675 H HA   . GLU C 1 43 ? -15.473 44.766 -20.751 1.00 17.36 ? 1121 GLU B HA   1 
ATOM   1676 H HB2  . GLU C 1 43 ? -15.720 46.809 -22.659 1.00 15.20 ? 1121 GLU B HB2  1 
ATOM   1677 H HB3  . GLU C 1 43 ? -16.732 45.588 -22.546 1.00 15.20 ? 1121 GLU B HB3  1 
ATOM   1678 H HG2  . GLU C 1 43 ? -16.365 47.460 -20.493 1.00 21.05 ? 1121 GLU B HG2  1 
ATOM   1679 H HG3  . GLU C 1 43 ? -17.558 47.536 -21.540 1.00 21.05 ? 1121 GLU B HG3  1 
ATOM   1680 N N    . TRP C 1 44 ? -13.181 44.697 -22.833 1.00 9.51  ? 1122 TRP B N    1 
ATOM   1681 C CA   . TRP C 1 44 ? -12.537 43.956 -23.904 1.00 9.21  ? 1122 TRP B CA   1 
ATOM   1682 C C    . TRP C 1 44 ? -11.126 43.551 -23.509 1.00 8.56  ? 1122 TRP B C    1 
ATOM   1683 O O    . TRP C 1 44 ? -10.279 44.405 -23.239 1.00 8.54  ? 1122 TRP B O    1 
ATOM   1684 C CB   . TRP C 1 44 ? -12.491 44.801 -25.167 1.00 10.00 ? 1122 TRP B CB   1 
ATOM   1685 C CG   . TRP C 1 44 ? -13.802 45.027 -25.837 1.00 6.81  ? 1122 TRP B CG   1 
ATOM   1686 C CD1  . TRP C 1 44 ? -14.629 46.083 -25.654 1.00 9.32  ? 1122 TRP B CD1  1 
ATOM   1687 C CD2  . TRP C 1 44 ? -14.436 44.183 -26.788 1.00 6.25  ? 1122 TRP B CD2  1 
ATOM   1688 N NE1  . TRP C 1 44 ? -15.711 45.976 -26.449 1.00 9.84  ? 1122 TRP B NE1  1 
ATOM   1689 C CE2  . TRP C 1 44 ? -15.638 44.805 -27.153 1.00 10.05 ? 1122 TRP B CE2  1 
ATOM   1690 C CE3  . TRP C 1 44 ? -14.109 42.954 -27.366 1.00 7.06  ? 1122 TRP B CE3  1 
ATOM   1691 C CZ2  . TRP C 1 44 ? -16.515 44.259 -28.087 1.00 7.93  ? 1122 TRP B CZ2  1 
ATOM   1692 C CZ3  . TRP C 1 44 ? -14.971 42.415 -28.313 1.00 7.80  ? 1122 TRP B CZ3  1 
ATOM   1693 C CH2  . TRP C 1 44 ? -16.173 43.061 -28.646 1.00 11.01 ? 1122 TRP B CH2  1 
ATOM   1694 H H    . TRP C 1 44 ? -12.688 45.311 -22.487 1.00 11.55 ? 1122 TRP B H    1 
ATOM   1695 H HA   . TRP C 1 44 ? -13.037 43.140 -24.059 1.00 11.20 ? 1122 TRP B HA   1 
ATOM   1696 H HB2  . TRP C 1 44 ? -12.131 45.672 -24.938 1.00 12.14 ? 1122 TRP B HB2  1 
ATOM   1697 H HB3  . TRP C 1 44 ? -11.912 44.360 -25.808 1.00 12.14 ? 1122 TRP B HB3  1 
ATOM   1698 H HD1  . TRP C 1 44 ? -14.473 46.783 -25.062 1.00 11.33 ? 1122 TRP B HD1  1 
ATOM   1699 H HE1  . TRP C 1 44 ? -16.347 46.553 -26.506 1.00 11.96 ? 1122 TRP B HE1  1 
ATOM   1700 H HE3  . TRP C 1 44 ? -13.331 42.506 -27.123 1.00 8.61  ? 1122 TRP B HE3  1 
ATOM   1701 H HZ2  . TRP C 1 44 ? -17.303 44.693 -28.321 1.00 9.67  ? 1122 TRP B HZ2  1 
ATOM   1702 H HZ3  . TRP C 1 44 ? -14.749 41.615 -28.732 1.00 9.50  ? 1122 TRP B HZ3  1 
ATOM   1703 H HH2  . TRP C 1 44 ? -16.748 42.665 -29.260 1.00 13.36 ? 1122 TRP B HH2  1 
ATOM   1704 N N    . TRP C 1 45 ? -10.874 42.254 -23.521 1.00 7.32  ? 1123 TRP B N    1 
ATOM   1705 C CA   . TRP C 1 45 ? -9.572  41.696 -23.257 1.00 10.73 ? 1123 TRP B CA   1 
ATOM   1706 C C    . TRP C 1 45 ? -9.023  41.060 -24.514 1.00 7.61  ? 1123 TRP B C    1 
ATOM   1707 O O    . TRP C 1 45 ? -9.707  40.965 -25.523 1.00 9.16  ? 1123 TRP B O    1 
ATOM   1708 C CB   . TRP C 1 45 ? -9.659  40.680 -22.132 1.00 7.43  ? 1123 TRP B CB   1 
ATOM   1709 C CG   . TRP C 1 45 ? -9.928  41.312 -20.800 1.00 11.09 ? 1123 TRP B CG   1 
ATOM   1710 C CD1  . TRP C 1 45 ? -9.974  42.656 -20.497 1.00 11.42 ? 1123 TRP B CD1  1 
ATOM   1711 C CD2  . TRP C 1 45 ? -10.152 40.621 -19.582 1.00 10.18 ? 1123 TRP B CD2  1 
ATOM   1712 N NE1  . TRP C 1 45 ? -10.221 42.826 -19.155 1.00 11.99 ? 1123 TRP B NE1  1 
ATOM   1713 C CE2  . TRP C 1 45 ? -10.329 41.592 -18.569 1.00 10.85 ? 1123 TRP B CE2  1 
ATOM   1714 C CE3  . TRP C 1 45 ? -10.231 39.268 -19.244 1.00 11.26 ? 1123 TRP B CE3  1 
ATOM   1715 C CZ2  . TRP C 1 45 ? -10.568 41.248 -17.239 1.00 17.88 ? 1123 TRP B CZ2  1 
ATOM   1716 C CZ3  . TRP C 1 45 ? -10.485 38.931 -17.902 1.00 18.97 ? 1123 TRP B CZ3  1 
ATOM   1717 C CH2  . TRP C 1 45 ? -10.660 39.920 -16.934 1.00 14.57 ? 1123 TRP B CH2  1 
ATOM   1718 H H    . TRP C 1 45 ? -11.470 41.657 -23.686 1.00 8.93  ? 1123 TRP B H    1 
ATOM   1719 H HA   . TRP C 1 45 ? -8.959  42.398 -22.985 1.00 13.03 ? 1123 TRP B HA   1 
ATOM   1720 H HB2  . TRP C 1 45 ? -10.381 40.060 -22.322 1.00 9.06  ? 1123 TRP B HB2  1 
ATOM   1721 H HB3  . TRP C 1 45 ? -8.817  40.202 -22.073 1.00 9.06  ? 1123 TRP B HB3  1 
ATOM   1722 H HD1  . TRP C 1 45 ? -9.854  43.346 -21.110 1.00 13.85 ? 1123 TRP B HD1  1 
ATOM   1723 H HE1  . TRP C 1 45 ? -10.296 43.581 -18.750 1.00 14.54 ? 1123 TRP B HE1  1 
ATOM   1724 H HE3  . TRP C 1 45 ? -10.119 38.608 -19.890 1.00 13.65 ? 1123 TRP B HE3  1 
ATOM   1725 H HZ2  . TRP C 1 45 ? -10.662 41.901 -16.583 1.00 21.60 ? 1123 TRP B HZ2  1 
ATOM   1726 H HZ3  . TRP C 1 45 ? -10.537 38.035 -17.657 1.00 22.91 ? 1123 TRP B HZ3  1 
ATOM   1727 H HH2  . TRP C 1 45 ? -10.845 39.669 -16.057 1.00 17.63 ? 1123 TRP B HH2  1 
ATOM   1728 N N    . ILE C 1 46 ? -7.773  40.623 -24.434 1.00 8.77  ? 1124 ILE B N    1 
ATOM   1729 C CA   . ILE C 1 46 ? -7.058  40.067 -25.577 1.00 6.47  ? 1124 ILE B CA   1 
ATOM   1730 C C    . ILE C 1 46 ? -6.526  38.698 -25.199 1.00 4.58  ? 1124 ILE B C    1 
ATOM   1731 O O    . ILE C 1 46 ? -6.072  38.489 -24.073 1.00 6.52  ? 1124 ILE B O    1 
ATOM   1732 C CB   . ILE C 1 46 ? -5.919  40.994 -26.034 1.00 8.81  ? 1124 ILE B CB   1 
ATOM   1733 C CG1  . ILE C 1 46 ? -6.430  42.433 -26.169 1.00 11.79 ? 1124 ILE B CG1  1 
ATOM   1734 C CG2  . ILE C 1 46 ? -5.367  40.487 -27.356 1.00 11.85 ? 1124 ILE B CG2  1 
ATOM   1735 C CD1  . ILE C 1 46 ? -5.323  43.450 -26.389 1.00 15.29 ? 1124 ILE B CD1  1 
ATOM   1736 H H    . ILE C 1 46 ? -7.307  40.638 -23.712 1.00 10.67 ? 1124 ILE B H    1 
ATOM   1737 H HA   . ILE C 1 46 ? -7.673  39.956 -26.319 1.00 7.91  ? 1124 ILE B HA   1 
ATOM   1738 H HB   . ILE C 1 46 ? -5.211  40.991 -25.371 1.00 10.72 ? 1124 ILE B HB   1 
ATOM   1739 H HG12 . ILE C 1 46 ? -7.032  42.481 -26.928 1.00 14.29 ? 1124 ILE B HG12 1 
ATOM   1740 H HG13 . ILE C 1 46 ? -6.900  42.676 -25.356 1.00 14.29 ? 1124 ILE B HG13 1 
ATOM   1741 H HG21 . ILE C 1 46 ? -4.629  41.054 -27.629 1.00 14.37 ? 1124 ILE B HG21 1 
ATOM   1742 H HG22 . ILE C 1 46 ? -5.059  39.575 -27.241 1.00 14.37 ? 1124 ILE B HG22 1 
ATOM   1743 H HG23 . ILE C 1 46 ? -6.070  40.517 -28.024 1.00 14.37 ? 1124 ILE B HG23 1 
ATOM   1744 H HD11 . ILE C 1 46 ? -5.703  44.342 -26.354 1.00 18.49 ? 1124 ILE B HD11 1 
ATOM   1745 H HD12 . ILE C 1 46 ? -4.656  43.346 -25.692 1.00 18.49 ? 1124 ILE B HD12 1 
ATOM   1746 H HD13 . ILE C 1 46 ? -4.921  43.296 -27.258 1.00 18.49 ? 1124 ILE B HD13 1 
ATOM   1747 N N    . GLY C 1 47 ? -6.604  37.754 -26.123 1.00 3.61  ? 1125 GLY B N    1 
ATOM   1748 C CA   . GLY C 1 47 ? -6.137  36.433 -25.769 1.00 3.23  ? 1125 GLY B CA   1 
ATOM   1749 C C    . GLY C 1 47 ? -6.198  35.489 -26.933 1.00 2.76  ? 1125 GLY B C    1 
ATOM   1750 O O    . GLY C 1 47 ? -6.435  35.882 -28.077 1.00 7.48  ? 1125 GLY B O    1 
ATOM   1751 H H    . GLY C 1 47 ? -6.909  37.850 -26.922 1.00 4.48  ? 1125 GLY B H    1 
ATOM   1752 H HA2  . GLY C 1 47 ? -5.217  36.486 -25.464 1.00 4.03  ? 1125 GLY B HA2  1 
ATOM   1753 H HA3  . GLY C 1 47 ? -6.686  36.075 -25.054 1.00 4.03  ? 1125 GLY B HA3  1 
ATOM   1754 N N    . HIS C 1 48 ? -6.040  34.215 -26.613 1.00 3.12  ? 1126 HIS B N    1 
ATOM   1755 C CA   . HIS C 1 48 ? -6.079  33.201 -27.643 1.00 4.33  ? 1126 HIS B CA   1 
ATOM   1756 C C    . HIS C 1 48 ? -6.639  31.920 -27.088 1.00 3.54  ? 1126 HIS B C    1 
ATOM   1757 O O    . HIS C 1 48 ? -6.706  31.731 -25.872 1.00 12.34 ? 1126 HIS B O    1 
ATOM   1758 C CB   . HIS C 1 48 ? -4.705  32.917 -28.228 1.00 5.91  ? 1126 HIS B CB   1 
ATOM   1759 C CG   . HIS C 1 48 ? -3.693  32.508 -27.215 1.00 5.72  ? 1126 HIS B CG   1 
ATOM   1760 N ND1  . HIS C 1 48 ? -2.857  33.411 -26.615 1.00 8.14  ? 1126 HIS B ND1  1 
ATOM   1761 C CD2  . HIS C 1 48 ? -3.379  31.296 -26.701 1.00 6.80  ? 1126 HIS B CD2  1 
ATOM   1762 C CE1  . HIS C 1 48 ? -2.049  32.774 -25.781 1.00 8.41  ? 1126 HIS B CE1  1 
ATOM   1763 N NE2  . HIS C 1 48 ? -2.328  31.486 -25.838 1.00 10.27 ? 1126 HIS B NE2  1 
ATOM   1764 H H    . HIS C 1 48 ? -5.910  33.920 -25.815 1.00 3.89  ? 1126 HIS B H    1 
ATOM   1765 H HA   . HIS C 1 48 ? -6.666  33.524 -28.345 1.00 5.35  ? 1126 HIS B HA   1 
ATOM   1766 H HB2  . HIS C 1 48 ? -4.784  32.198 -28.874 1.00 7.24  ? 1126 HIS B HB2  1 
ATOM   1767 H HB3  . HIS C 1 48 ? -4.380  33.721 -28.663 1.00 7.24  ? 1126 HIS B HB3  1 
ATOM   1768 H HD2  . HIS C 1 48 ? -3.796  30.488 -26.895 1.00 8.31  ? 1126 HIS B HD2  1 
ATOM   1769 H HE1  . HIS C 1 48 ? -1.397  33.167 -25.247 1.00 10.23 ? 1126 HIS B HE1  1 
ATOM   1770 H HE2  . HIS C 1 48 ? -1.919  30.866 -25.405 1.00 12.48 ? 1126 HIS B HE2  1 
ATOM   1771 N N    . ILE C 1 49 ? -7.080  31.051 -27.998 1.00 8.68  ? 1127 ILE B N    1 
ATOM   1772 C CA   . ILE C 1 49 ? -7.736  29.812 -27.590 1.00 12.04 ? 1127 ILE B CA   1 
ATOM   1773 C C    . ILE C 1 49 ? -6.694  28.873 -27.002 1.00 13.01 ? 1127 ILE B C    1 
ATOM   1774 O O    . ILE C 1 49 ? -5.628  28.653 -27.597 1.00 9.34  ? 1127 ILE B O    1 
ATOM   1775 C CB   . ILE C 1 49 ? -8.460  29.151 -28.767 1.00 10.53 ? 1127 ILE B CB   1 
ATOM   1776 C CG1  . ILE C 1 49 ? -9.555  30.083 -29.292 1.00 13.07 ? 1127 ILE B CG1  1 
ATOM   1777 C CG2  . ILE C 1 49 ? -9.067  27.790 -28.334 1.00 8.96  ? 1127 ILE B CG2  1 
ATOM   1778 C CD1  . ILE C 1 49 ? -10.900 30.031 -28.477 1.00 8.02  ? 1127 ILE B CD1  1 
ATOM   1779 H H    . ILE C 1 49 ? -7.012  31.155 -28.849 1.00 10.56 ? 1127 ILE B H    1 
ATOM   1780 H HA   . ILE C 1 49 ? -8.399  30.020 -26.913 1.00 14.59 ? 1127 ILE B HA   1 
ATOM   1781 H HB   . ILE C 1 49 ? -7.819  28.989 -29.477 1.00 12.79 ? 1127 ILE B HB   1 
ATOM   1782 H HG12 . ILE C 1 49 ? -9.227  30.995 -29.258 1.00 15.83 ? 1127 ILE B HG12 1 
ATOM   1783 H HG13 . ILE C 1 49 ? -9.757  29.837 -30.208 1.00 15.83 ? 1127 ILE B HG13 1 
ATOM   1784 H HG21 . ILE C 1 49 ? -9.685  27.488 -29.017 1.00 10.90 ? 1127 ILE B HG21 1 
ATOM   1785 H HG22 . ILE C 1 49 ? -8.351  27.145 -28.227 1.00 10.90 ? 1127 ILE B HG22 1 
ATOM   1786 H HG23 . ILE C 1 49 ? -9.536  27.907 -27.492 1.00 10.90 ? 1127 ILE B HG23 1 
ATOM   1787 H HD11 . ILE C 1 49 ? -11.428 30.816 -28.689 1.00 9.77  ? 1127 ILE B HD11 1 
ATOM   1788 H HD12 . ILE C 1 49 ? -11.387 29.229 -28.723 1.00 9.77  ? 1127 ILE B HD12 1 
ATOM   1789 H HD13 . ILE C 1 49 ? -10.695 30.015 -27.529 1.00 9.77  ? 1127 ILE B HD13 1 
ATOM   1790 N N    . GLU C 1 50 ? -6.983  28.349 -25.812 1.00 7.89  ? 1128 GLU B N    1 
ATOM   1791 C CA   . GLU C 1 50 ? -6.114  27.356 -25.219 1.00 9.74  ? 1128 GLU B CA   1 
ATOM   1792 C C    . GLU C 1 50 ? -6.125  26.086 -26.051 1.00 8.78  ? 1128 GLU B C    1 
ATOM   1793 O O    . GLU C 1 50 ? -7.167  25.473 -26.261 1.00 10.13 ? 1128 GLU B O    1 
ATOM   1794 C CB   . GLU C 1 50 ? -6.533  27.047 -23.798 1.00 14.76 ? 1128 GLU B CB   1 
ATOM   1795 C CG   . GLU C 1 50 ? -5.774  25.882 -23.167 1.00 15.41 ? 1128 GLU B CG   1 
ATOM   1796 C CD   . GLU C 1 50 ? -6.453  25.382 -21.871 1.00 17.97 ? 1128 GLU B CD   1 
ATOM   1797 O OE1  . GLU C 1 50 ? -7.484  24.659 -21.906 1.00 17.29 ? 1128 GLU B OE1  1 
ATOM   1798 O OE2  . GLU C 1 50 ? -5.919  25.713 -20.800 1.00 21.70 ? 1128 GLU B OE2  1 
ATOM   1799 H H    . GLU C 1 50 ? -7.671  28.554 -25.339 1.00 9.61  ? 1128 GLU B H    1 
ATOM   1800 H HA   . GLU C 1 50 ? -5.213  27.713 -25.200 1.00 11.83 ? 1128 GLU B HA   1 
ATOM   1801 H HB2  . GLU C 1 50 ? -6.378  27.832 -23.250 1.00 17.85 ? 1128 GLU B HB2  1 
ATOM   1802 H HB3  . GLU C 1 50 ? -7.477  26.821 -23.794 1.00 17.85 ? 1128 GLU B HB3  1 
ATOM   1803 H HG2  . GLU C 1 50 ? -5.742  25.144 -23.796 1.00 18.64 ? 1128 GLU B HG2  1 
ATOM   1804 H HG3  . GLU C 1 50 ? -4.875  26.170 -22.946 1.00 18.64 ? 1128 GLU B HG3  1 
ATOM   1805 N N    . GLY C 1 51 ? -4.947  25.662 -26.485 1.00 9.72  ? 1129 GLY B N    1 
ATOM   1806 C CA   . GLY C 1 51 ? -4.842  24.542 -27.372 1.00 11.96 ? 1129 GLY B CA   1 
ATOM   1807 C C    . GLY C 1 51 ? -4.884  24.907 -28.835 1.00 11.45 ? 1129 GLY B C    1 
ATOM   1808 O O    . GLY C 1 51 ? -4.518  24.084 -29.661 1.00 12.25 ? 1129 GLY B O    1 
ATOM   1809 H H    . GLY C 1 51 ? -4.193  26.017 -26.272 1.00 11.81 ? 1129 GLY B H    1 
ATOM   1810 H HA2  . GLY C 1 51 ? -4.003  24.085 -27.202 1.00 14.49 ? 1129 GLY B HA2  1 
ATOM   1811 H HA3  . GLY C 1 51 ? -5.574  23.931 -27.195 1.00 14.49 ? 1129 GLY B HA3  1 
ATOM   1812 N N    . GLN C 1 52 ? -5.298  26.118 -29.181 1.00 12.37 ? 1130 GLN B N    1 
ATOM   1813 C CA   . GLN C 1 52 ? -5.354  26.576 -30.578 1.00 13.62 ? 1130 GLN B CA   1 
ATOM   1814 C C    . GLN C 1 52 ? -4.868  28.003 -30.647 1.00 11.66 ? 1130 GLN B C    1 
ATOM   1815 O O    . GLN C 1 52 ? -5.615  28.927 -31.041 1.00 12.45 ? 1130 GLN B O    1 
ATOM   1816 C CB   . GLN C 1 52 ? -6.766  26.418 -31.143 1.00 14.98 ? 1130 GLN B CB   1 
ATOM   1817 C CG   . GLN C 1 52 ? -7.328  25.018 -31.030 1.00 15.97 ? 1130 GLN B CG   1 
ATOM   1818 C CD   . GLN C 1 52 ? -8.826  24.969 -31.242 1.00 27.47 ? 1130 GLN B CD   1 
ATOM   1819 O OE1  . GLN C 1 52 ? -9.331  25.439 -32.257 1.00 22.80 ? 1130 GLN B OE1  1 
ATOM   1820 N NE2  . GLN C 1 52 ? -9.546  24.391 -30.281 1.00 29.74 ? 1130 GLN B NE2  1 
ATOM   1821 H H    . GLN C 1 52 ? -5.560  26.712 -28.617 1.00 14.99 ? 1130 GLN B H    1 
ATOM   1822 H HA   . GLN C 1 52 ? -4.755  26.037 -31.119 1.00 16.49 ? 1130 GLN B HA   1 
ATOM   1823 H HB2  . GLN C 1 52 ? -7.361  27.014 -30.661 1.00 18.12 ? 1130 GLN B HB2  1 
ATOM   1824 H HB3  . GLN C 1 52 ? -6.752  26.655 -32.084 1.00 18.12 ? 1130 GLN B HB3  1 
ATOM   1825 H HG2  . GLN C 1 52 ? -6.912  24.456 -31.702 1.00 19.31 ? 1130 GLN B HG2  1 
ATOM   1826 H HG3  . GLN C 1 52 ? -7.139  24.673 -30.144 1.00 19.31 ? 1130 GLN B HG3  1 
ATOM   1827 H HE21 . GLN C 1 52 ? -9.155  24.070 -29.585 1.00 35.84 ? 1130 GLN B HE21 1 
ATOM   1828 H HE22 . GLN C 1 52 ? -10.401 24.339 -30.356 1.00 35.84 ? 1130 GLN B HE22 1 
ATOM   1829 N N    . PRO C 1 53 ? -3.586  28.244 -30.366 1.00 16.59 ? 1131 PRO B N    1 
ATOM   1830 C CA   . PRO C 1 53 ? -3.101  29.600 -30.130 1.00 11.72 ? 1131 PRO B CA   1 
ATOM   1831 C C    . PRO C 1 53 ? -3.199  30.491 -31.335 1.00 11.26 ? 1131 PRO B C    1 
ATOM   1832 O O    . PRO C 1 53 ? -3.092  31.717 -31.186 1.00 7.28  ? 1131 PRO B O    1 
ATOM   1833 C CB   . PRO C 1 53 ? -1.631  29.411 -29.713 1.00 11.38 ? 1131 PRO B CB   1 
ATOM   1834 C CG   . PRO C 1 53 ? -1.338  27.935 -29.839 1.00 15.64 ? 1131 PRO B CG   1 
ATOM   1835 C CD   . PRO C 1 53 ? -2.476  27.286 -30.554 1.00 17.92 ? 1131 PRO B CD   1 
ATOM   1836 H HA   . PRO C 1 53 ? -3.593  29.987 -29.389 1.00 14.21 ? 1131 PRO B HA   1 
ATOM   1837 H HB2  . PRO C 1 53 ? -1.058  29.925 -30.303 1.00 13.81 ? 1131 PRO B HB2  1 
ATOM   1838 H HB3  . PRO C 1 53 ? -1.513  29.706 -28.796 1.00 13.81 ? 1131 PRO B HB3  1 
ATOM   1839 H HG2  . PRO C 1 53 ? -0.517  27.817 -30.342 1.00 18.91 ? 1131 PRO B HG2  1 
ATOM   1840 H HG3  . PRO C 1 53 ? -1.242  27.555 -28.952 1.00 18.91 ? 1131 PRO B HG3  1 
ATOM   1841 H HD2  . PRO C 1 53 ? -2.272  27.174 -31.496 1.00 21.65 ? 1131 PRO B HD2  1 
ATOM   1842 H HD3  . PRO C 1 53 ? -2.689  26.427 -30.157 1.00 21.65 ? 1131 PRO B HD3  1 
ATOM   1843 N N    . GLU C 1 54 ? -3.341  29.915 -32.528 1.00 9.95  ? 1132 GLU B N    1 
ATOM   1844 C CA   . GLU C 1 54 ? -3.480  30.740 -33.721 1.00 14.35 ? 1132 GLU B CA   1 
ATOM   1845 C C    . GLU C 1 54 ? -4.838  31.397 -33.796 1.00 12.15 ? 1132 GLU B C    1 
ATOM   1846 O O    . GLU C 1 54 ? -5.005  32.346 -34.562 1.00 10.83 ? 1132 GLU B O    1 
ATOM   1847 C CB   . GLU C 1 54 ? -3.253  29.932 -35.009 1.00 21.12 ? 1132 GLU B CB   1 
ATOM   1848 C CG   . GLU C 1 54 ? -1.925  29.170 -35.059 1.00 29.92 ? 1132 GLU B CG   1 
ATOM   1849 C CD   . GLU C 1 54 ? -0.689  30.058 -35.208 1.00 37.52 ? 1132 GLU B CD   1 
ATOM   1850 O OE1  . GLU C 1 54 ? 0.414   29.583 -34.829 1.00 39.06 ? 1132 GLU B OE1  1 
ATOM   1851 O OE2  . GLU C 1 54 ? -0.823  31.210 -35.706 1.00 38.20 ? 1132 GLU B OE2  1 
ATOM   1852 H H    . GLU C 1 54 ? -3.358  29.067 -32.669 1.00 12.09 ? 1132 GLU B H    1 
ATOM   1853 H HA   . GLU C 1 54 ? -2.790  31.421 -33.680 1.00 17.37 ? 1132 GLU B HA   1 
ATOM   1854 H HB2  . GLU C 1 54 ? -3.967  29.281 -35.095 1.00 25.49 ? 1132 GLU B HB2  1 
ATOM   1855 H HB3  . GLU C 1 54 ? -3.268  30.542 -35.763 1.00 25.49 ? 1132 GLU B HB3  1 
ATOM   1856 H HG2  . GLU C 1 54 ? -1.826  28.667 -34.235 1.00 36.05 ? 1132 GLU B HG2  1 
ATOM   1857 H HG3  . GLU C 1 54 ? -1.944  28.565 -35.816 1.00 36.05 ? 1132 GLU B HG3  1 
ATOM   1858 N N    . ARG C 1 55 ? -5.803  30.924 -33.016 1.00 13.71 ? 1133 ARG B N    1 
ATOM   1859 C CA   . ARG C 1 55 ? -7.089  31.578 -32.880 1.00 6.93  ? 1133 ARG B CA   1 
ATOM   1860 C C    . ARG C 1 55 ? -6.984  32.593 -31.750 1.00 8.12  ? 1133 ARG B C    1 
ATOM   1861 O O    . ARG C 1 55 ? -6.951  32.218 -30.573 1.00 9.21  ? 1133 ARG B O    1 
ATOM   1862 C CB   . ARG C 1 55 ? -8.176  30.554 -32.611 1.00 6.86  ? 1133 ARG B CB   1 
ATOM   1863 C CG   . ARG C 1 55 ? -8.417  29.583 -33.731 1.00 9.08  ? 1133 ARG B CG   1 
ATOM   1864 C CD   . ARG C 1 55 ? -9.404  28.522 -33.308 1.00 13.73 ? 1133 ARG B CD   1 
ATOM   1865 N NE   . ARG C 1 55 ? -10.656 29.129 -32.851 1.00 7.09  ? 1133 ARG B NE   1 
ATOM   1866 C CZ   . ARG C 1 55 ? -11.481 28.592 -31.962 1.00 8.57  ? 1133 ARG B CZ   1 
ATOM   1867 N NH1  . ARG C 1 55 ? -11.283 27.383 -31.471 1.00 12.43 ? 1133 ARG B NH1  1 
ATOM   1868 N NH2  . ARG C 1 55 ? -12.560 29.271 -31.584 1.00 9.82  ? 1133 ARG B NH2  1 
ATOM   1869 H H    . ARG C 1 55 ? -5.730  30.208 -32.545 1.00 16.60 ? 1133 ARG B H    1 
ATOM   1870 H HA   . ARG C 1 55 ? -7.315  32.049 -33.698 1.00 8.47  ? 1133 ARG B HA   1 
ATOM   1871 H HB2  . ARG C 1 55 ? -7.928  30.039 -31.828 1.00 8.38  ? 1133 ARG B HB2  1 
ATOM   1872 H HB3  . ARG C 1 55 ? -9.009  31.024 -32.449 1.00 8.38  ? 1133 ARG B HB3  1 
ATOM   1873 H HG2  . ARG C 1 55 ? -8.780  30.054 -34.498 1.00 11.04 ? 1133 ARG B HG2  1 
ATOM   1874 H HG3  . ARG C 1 55 ? -7.583  29.151 -33.972 1.00 11.04 ? 1133 ARG B HG3  1 
ATOM   1875 H HD2  . ARG C 1 55 ? -9.599  27.942 -34.061 1.00 16.62 ? 1133 ARG B HD2  1 
ATOM   1876 H HD3  . ARG C 1 55 ? -9.029  28.004 -32.579 1.00 16.62 ? 1133 ARG B HD3  1 
ATOM   1877 H HE   . ARG C 1 55 ? -10.873 29.891 -33.186 1.00 8.65  ? 1133 ARG B HE   1 
ATOM   1878 H HH11 . ARG C 1 55 ? -10.605 26.921 -31.728 1.00 15.06 ? 1133 ARG B HH11 1 
ATOM   1879 H HH12 . ARG C 1 55 ? -11.833 27.058 -30.896 1.00 15.06 ? 1133 ARG B HH12 1 
ATOM   1880 H HH21 . ARG C 1 55 ? -12.717 30.049 -31.916 1.00 11.93 ? 1133 ARG B HH21 1 
ATOM   1881 H HH22 . ARG C 1 55 ? -13.102 28.933 -31.008 1.00 11.93 ? 1133 ARG B HH22 1 
ATOM   1882 N N    . LYS C 1 56 ? -6.935  33.879 -32.094 1.00 6.25  ? 1134 LYS B N    1 
ATOM   1883 C CA   . LYS C 1 56 ? -6.555  34.890 -31.112 1.00 7.30  ? 1134 LYS B CA   1 
ATOM   1884 C C    . LYS C 1 56 ? -7.184  36.215 -31.460 1.00 6.75  ? 1134 LYS B C    1 
ATOM   1885 O O    . LYS C 1 56 ? -7.566  36.446 -32.603 1.00 12.57 ? 1134 LYS B O    1 
ATOM   1886 C CB   . LYS C 1 56 ? -5.025  35.062 -31.048 1.00 5.78  ? 1134 LYS B CB   1 
ATOM   1887 C CG   . LYS C 1 56 ? -4.352  35.432 -32.362 1.00 7.29  ? 1134 LYS B CG   1 
ATOM   1888 C CD   . LYS C 1 56 ? -2.817  35.255 -32.240 1.00 12.06 ? 1134 LYS B CD   1 
ATOM   1889 C CE   . LYS C 1 56 ? -1.985  36.184 -33.124 1.00 15.89 ? 1134 LYS B CE   1 
ATOM   1890 N NZ   . LYS C 1 56 ? -2.645  36.437 -34.417 1.00 21.68 ? 1134 LYS B NZ   1 
ATOM   1891 H H    . LYS C 1 56 ? -7.114  34.186 -32.878 1.00 7.65  ? 1134 LYS B H    1 
ATOM   1892 H HA   . LYS C 1 56 ? -6.891  34.612 -30.246 1.00 8.91  ? 1134 LYS B HA   1 
ATOM   1893 H HB2  . LYS C 1 56 ? -4.824  35.766 -30.412 1.00 7.08  ? 1134 LYS B HB2  1 
ATOM   1894 H HB3  . LYS C 1 56 ? -4.636  34.225 -30.750 1.00 7.08  ? 1134 LYS B HB3  1 
ATOM   1895 H HG2  . LYS C 1 56 ? -4.677  34.854 -33.069 1.00 8.90  ? 1134 LYS B HG2  1 
ATOM   1896 H HG3  . LYS C 1 56 ? -4.543  36.358 -32.577 1.00 8.90  ? 1134 LYS B HG3  1 
ATOM   1897 H HD2  . LYS C 1 56 ? -2.560  35.424 -31.320 1.00 14.62 ? 1134 LYS B HD2  1 
ATOM   1898 H HD3  . LYS C 1 56 ? -2.592  34.344 -32.486 1.00 14.62 ? 1134 LYS B HD3  1 
ATOM   1899 H HE2  . LYS C 1 56 ? -1.865  37.034 -32.671 1.00 19.21 ? 1134 LYS B HE2  1 
ATOM   1900 H HE3  . LYS C 1 56 ? -1.123  35.775 -33.297 1.00 19.21 ? 1134 LYS B HE3  1 
ATOM   1901 H HZ1  . LYS C 1 56 ? -2.879  35.666 -34.795 1.00 26.16 ? 1134 LYS B HZ1  1 
ATOM   1902 H HZ2  . LYS C 1 56 ? -3.375  36.932 -34.294 1.00 26.16 ? 1134 LYS B HZ2  1 
ATOM   1903 H HZ3  . LYS C 1 56 ? -2.091  36.870 -34.962 1.00 26.16 ? 1134 LYS B HZ3  1 
ATOM   1904 N N    . GLY C 1 57 ? -7.271  37.099 -30.478 1.00 8.09  ? 1135 GLY B N    1 
ATOM   1905 C CA   . GLY C 1 57 ? -7.748  38.439 -30.737 1.00 7.03  ? 1135 GLY B CA   1 
ATOM   1906 C C    . GLY C 1 57 ? -8.440  39.024 -29.516 1.00 9.96  ? 1135 GLY B C    1 
ATOM   1907 O O    . GLY C 1 57 ? -8.326  38.520 -28.415 1.00 4.56  ? 1135 GLY B O    1 
ATOM   1908 H H    . GLY C 1 57 ? -7.060  36.944 -29.659 1.00 9.85  ? 1135 GLY B H    1 
ATOM   1909 H HA2  . GLY C 1 57 ? -7.001  39.011 -30.973 1.00 8.58  ? 1135 GLY B HA2  1 
ATOM   1910 H HA3  . GLY C 1 57 ? -8.380  38.424 -31.473 1.00 8.58  ? 1135 GLY B HA3  1 
ATOM   1911 N N    . VAL C 1 58 ? -9.151  40.126 -29.744 1.00 7.52  ? 1136 VAL B N    1 
ATOM   1912 C CA   . VAL C 1 58 ? -9.846  40.881 -28.708 1.00 9.08  ? 1136 VAL B CA   1 
ATOM   1913 C C    . VAL C 1 58 ? -11.219 40.270 -28.515 1.00 5.03  ? 1136 VAL B C    1 
ATOM   1914 O O    . VAL C 1 58 ? -11.869 39.858 -29.485 1.00 6.48  ? 1136 VAL B O    1 
ATOM   1915 C CB   . VAL C 1 58 ? -9.921  42.368 -29.120 1.00 10.27 ? 1136 VAL B CB   1 
ATOM   1916 C CG1  . VAL C 1 58 ? -10.630 43.201 -28.096 1.00 14.36 ? 1136 VAL B CG1  1 
ATOM   1917 C CG2  . VAL C 1 58 ? -8.506  42.895 -29.347 1.00 7.74  ? 1136 VAL B CG2  1 
ATOM   1918 H H    . VAL C 1 58 ? -9.248  40.470 -30.526 1.00 9.16  ? 1136 VAL B H    1 
ATOM   1919 H HA   . VAL C 1 58 ? -9.375  40.822 -27.862 1.00 11.04 ? 1136 VAL B HA   1 
ATOM   1920 H HB   . VAL C 1 58 ? -10.433 42.438 -29.940 1.00 12.47 ? 1136 VAL B HB   1 
ATOM   1921 H HG11 . VAL C 1 58 ? -10.362 44.127 -28.201 1.00 17.38 ? 1136 VAL B HG11 1 
ATOM   1922 H HG12 . VAL C 1 58 ? -11.587 43.117 -28.228 1.00 17.38 ? 1136 VAL B HG12 1 
ATOM   1923 H HG13 . VAL C 1 58 ? -10.389 42.886 -27.211 1.00 17.38 ? 1136 VAL B HG13 1 
ATOM   1924 H HG21 . VAL C 1 58 ? -8.514  43.508 -30.099 1.00 9.44  ? 1136 VAL B HG21 1 
ATOM   1925 H HG22 . VAL C 1 58 ? -8.208  43.356 -28.547 1.00 9.44  ? 1136 VAL B HG22 1 
ATOM   1926 H HG23 . VAL C 1 58 ? -7.917  42.148 -29.536 1.00 9.44  ? 1136 VAL B HG23 1 
ATOM   1927 N N    . PHE C 1 59 ? -11.676 40.184 -27.268 1.00 7.56  ? 1137 PHE B N    1 
ATOM   1928 C CA   . PHE C 1 59 ? -12.945 39.538 -26.999 1.00 6.58  ? 1137 PHE B CA   1 
ATOM   1929 C C    . PHE C 1 59 ? -13.640 40.222 -25.849 1.00 6.37  ? 1137 PHE B C    1 
ATOM   1930 O O    . PHE C 1 59 ? -12.966 40.854 -25.023 1.00 8.49  ? 1137 PHE B O    1 
ATOM   1931 C CB   . PHE C 1 59 ? -12.791 38.041 -26.665 1.00 7.47  ? 1137 PHE B CB   1 
ATOM   1932 C CG   . PHE C 1 59 ? -12.001 37.790 -25.431 1.00 7.58  ? 1137 PHE B CG   1 
ATOM   1933 C CD1  . PHE C 1 59 ? -10.631 37.760 -25.489 1.00 7.89  ? 1137 PHE B CD1  1 
ATOM   1934 C CD2  . PHE C 1 59 ? -12.625 37.635 -24.207 1.00 9.59  ? 1137 PHE B CD2  1 
ATOM   1935 C CE1  . PHE C 1 59 ? -9.896  37.548 -24.373 1.00 6.79  ? 1137 PHE B CE1  1 
ATOM   1936 C CE2  . PHE C 1 59 ? -11.873 37.417 -23.061 1.00 6.69  ? 1137 PHE B CE2  1 
ATOM   1937 C CZ   . PHE C 1 59 ? -10.509 37.395 -23.159 1.00 7.68  ? 1137 PHE B CZ   1 
ATOM   1938 H H    . PHE C 1 59 ? -11.271 40.491 -26.574 1.00 9.21  ? 1137 PHE B H    1 
ATOM   1939 H HA   . PHE C 1 59 ? -13.490 39.633 -27.796 1.00 8.04  ? 1137 PHE B HA   1 
ATOM   1940 H HB2  . PHE C 1 59 ? -13.672 37.656 -26.538 1.00 9.11  ? 1137 PHE B HB2  1 
ATOM   1941 H HB3  . PHE C 1 59 ? -12.340 37.601 -27.403 1.00 9.11  ? 1137 PHE B HB3  1 
ATOM   1942 H HD1  . PHE C 1 59 ? -10.202 37.888 -26.304 1.00 9.62  ? 1137 PHE B HD1  1 
ATOM   1943 H HD2  . PHE C 1 59 ? -13.553 37.677 -24.152 1.00 11.65 ? 1137 PHE B HD2  1 
ATOM   1944 H HE1  . PHE C 1 59 ? -8.969  37.505 -24.431 1.00 8.29  ? 1137 PHE B HE1  1 
ATOM   1945 H HE2  . PHE C 1 59 ? -12.290 37.288 -22.240 1.00 8.17  ? 1137 PHE B HE2  1 
ATOM   1946 H HZ   . PHE C 1 59 ? -9.993  37.275 -22.394 1.00 9.36  ? 1137 PHE B HZ   1 
ATOM   1947 N N    . PRO C 1 60 ? -14.968 40.138 -25.758 1.00 9.01  ? 1138 PRO B N    1 
ATOM   1948 C CA   . PRO C 1 60 ? -15.694 40.831 -24.697 1.00 6.56  ? 1138 PRO B CA   1 
ATOM   1949 C C    . PRO C 1 60 ? -15.587 40.075 -23.388 1.00 10.52 ? 1138 PRO B C    1 
ATOM   1950 O O    . PRO C 1 60 ? -15.834 38.870 -23.332 1.00 9.85  ? 1138 PRO B O    1 
ATOM   1951 C CB   . PRO C 1 60 ? -17.137 40.866 -25.202 1.00 7.98  ? 1138 PRO B CB   1 
ATOM   1952 C CG   . PRO C 1 60 ? -17.229 39.863 -26.302 1.00 10.74 ? 1138 PRO B CG   1 
ATOM   1953 C CD   . PRO C 1 60 ? -15.844 39.327 -26.607 1.00 6.98  ? 1138 PRO B CD   1 
ATOM   1954 H HA   . PRO C 1 60 ? -15.363 41.736 -24.586 1.00 8.01  ? 1138 PRO B HA   1 
ATOM   1955 H HB2  . PRO C 1 60 ? -17.740 40.634 -24.478 1.00 9.73  ? 1138 PRO B HB2  1 
ATOM   1956 H HB3  . PRO C 1 60 ? -17.343 41.755 -25.532 1.00 9.73  ? 1138 PRO B HB3  1 
ATOM   1957 H HG2  . PRO C 1 60 ? -17.809 39.139 -26.019 1.00 13.03 ? 1138 PRO B HG2  1 
ATOM   1958 H HG3  . PRO C 1 60 ? -17.597 40.295 -27.089 1.00 13.03 ? 1138 PRO B HG3  1 
ATOM   1959 H HD2  . PRO C 1 60 ? -15.779 38.388 -26.372 1.00 8.53  ? 1138 PRO B HD2  1 
ATOM   1960 H HD3  . PRO C 1 60 ? -15.626 39.450 -27.544 1.00 8.53  ? 1138 PRO B HD3  1 
ATOM   1961 N N    . VAL C 1 61 ? -15.259 40.804 -22.321 1.00 9.41  ? 1139 VAL B N    1 
ATOM   1962 C CA   . VAL C 1 61 ? -15.108 40.179 -21.012 1.00 12.35 ? 1139 VAL B CA   1 
ATOM   1963 C C    . VAL C 1 61 ? -16.438 39.611 -20.537 1.00 14.74 ? 1139 VAL B C    1 
ATOM   1964 O O    . VAL C 1 61 ? -16.478 38.578 -19.853 1.00 8.49  ? 1139 VAL B O    1 
ATOM   1965 C CB   . VAL C 1 61 ? -14.550 41.211 -20.023 1.00 14.88 ? 1139 VAL B CB   1 
ATOM   1966 C CG1  . VAL C 1 61 ? -14.548 40.674 -18.598 1.00 18.26 ? 1139 VAL B CG1  1 
ATOM   1967 C CG2  . VAL C 1 61 ? -13.148 41.615 -20.478 1.00 12.71 ? 1139 VAL B CG2  1 
ATOM   1968 H H    . VAL C 1 61 ? -15.119 41.652 -22.329 1.00 11.43 ? 1139 VAL B H    1 
ATOM   1969 H HA   . VAL C 1 61 ? -14.481 39.442 -21.077 1.00 14.96 ? 1139 VAL B HA   1 
ATOM   1970 H HB   . VAL C 1 61 ? -15.117 41.998 -20.012 1.00 18.00 ? 1139 VAL B HB   1 
ATOM   1971 H HG11 . VAL C 1 61 ? -13.982 41.239 -18.048 1.00 22.05 ? 1139 VAL B HG11 1 
ATOM   1972 H HG12 . VAL C 1 61 ? -15.456 40.682 -18.256 1.00 22.05 ? 1139 VAL B HG12 1 
ATOM   1973 H HG13 . VAL C 1 61 ? -14.204 39.767 -18.602 1.00 22.05 ? 1139 VAL B HG13 1 
ATOM   1974 H HG21 . VAL C 1 61 ? -12.731 42.148 -19.783 1.00 15.40 ? 1139 VAL B HG21 1 
ATOM   1975 H HG22 . VAL C 1 61 ? -12.625 40.814 -20.640 1.00 15.40 ? 1139 VAL B HG22 1 
ATOM   1976 H HG23 . VAL C 1 61 ? -13.219 42.134 -21.295 1.00 15.40 ? 1139 VAL B HG23 1 
ATOM   1977 N N    . SER C 1 62 ? -17.540 40.257 -20.911 1.00 10.02 ? 1140 SER B N    1 
ATOM   1978 C CA   . SER C 1 62 ? -18.846 39.791 -20.496 1.00 17.52 ? 1140 SER B CA   1 
ATOM   1979 C C    . SER C 1 62 ? -19.224 38.476 -21.142 1.00 14.05 ? 1140 SER B C    1 
ATOM   1980 O O    . SER C 1 62 ? -20.236 37.901 -20.757 1.00 10.87 ? 1140 SER B O    1 
ATOM   1981 C CB   . SER C 1 62 ? -19.903 40.832 -20.839 1.00 11.04 ? 1140 SER B CB   1 
ATOM   1982 O OG   . SER C 1 62 ? -19.932 41.010 -22.238 1.00 12.09 ? 1140 SER B OG   1 
ATOM   1983 H H    . SER C 1 62 ? -17.551 40.963 -21.402 1.00 12.17 ? 1140 SER B H    1 
ATOM   1984 H HA   . SER C 1 62 ? -18.839 39.669 -19.534 1.00 21.17 ? 1140 SER B HA   1 
ATOM   1985 H HB2  . SER C 1 62 ? -20.771 40.525 -20.534 1.00 13.40 ? 1140 SER B HB2  1 
ATOM   1986 H HB3  . SER C 1 62 ? -19.679 41.673 -20.411 1.00 13.40 ? 1140 SER B HB3  1 
ATOM   1987 H HG   . SER C 1 62 ? -20.525 41.567 -22.445 1.00 14.65 ? 1140 SER B HG   1 
ATOM   1988 N N    . PHE C 1 63 ? -18.456 37.978 -22.104 1.00 8.17  ? 1141 PHE B N    1 
ATOM   1989 C CA   . PHE C 1 63 ? -18.796 36.704 -22.720 1.00 8.46  ? 1141 PHE B CA   1 
ATOM   1990 C C    . PHE C 1 63 ? -18.012 35.558 -22.110 1.00 6.65  ? 1141 PHE B C    1 
ATOM   1991 O O    . PHE C 1 63 ? -18.074 34.428 -22.624 1.00 8.39  ? 1141 PHE B O    1 
ATOM   1992 C CB   . PHE C 1 63 ? -18.557 36.720 -24.230 1.00 9.78  ? 1141 PHE B CB   1 
ATOM   1993 C CG   . PHE C 1 63 ? -19.592 37.428 -25.035 1.00 9.94  ? 1141 PHE B CG   1 
ATOM   1994 C CD1  . PHE C 1 63 ? -20.092 38.650 -24.639 1.00 13.72 ? 1141 PHE B CD1  1 
ATOM   1995 C CD2  . PHE C 1 63 ? -20.014 36.882 -26.252 1.00 10.99 ? 1141 PHE B CD2  1 
ATOM   1996 C CE1  . PHE C 1 63 ? -20.984 39.302 -25.429 1.00 12.33 ? 1141 PHE B CE1  1 
ATOM   1997 C CE2  . PHE C 1 63 ? -20.925 37.521 -27.023 1.00 10.77 ? 1141 PHE B CE2  1 
ATOM   1998 C CZ   . PHE C 1 63 ? -21.409 38.743 -26.618 1.00 10.48 ? 1141 PHE B CZ   1 
ATOM   1999 H H    . PHE C 1 63 ? -17.746 38.353 -22.410 1.00 9.95  ? 1141 PHE B H    1 
ATOM   2000 H HA   . PHE C 1 63 ? -19.745 36.560 -22.584 1.00 10.29 ? 1141 PHE B HA   1 
ATOM   2001 H HB2  . PHE C 1 63 ? -17.709 37.158 -24.401 1.00 11.89 ? 1141 PHE B HB2  1 
ATOM   2002 H HB3  . PHE C 1 63 ? -18.526 35.802 -24.544 1.00 11.89 ? 1141 PHE B HB3  1 
ATOM   2003 H HD1  . PHE C 1 63 ? -19.819 39.027 -23.834 1.00 16.61 ? 1141 PHE B HD1  1 
ATOM   2004 H HD2  . PHE C 1 63 ? -19.663 36.069 -26.536 1.00 13.33 ? 1141 PHE B HD2  1 
ATOM   2005 H HE1  . PHE C 1 63 ? -21.312 40.132 -25.166 1.00 14.95 ? 1141 PHE B HE1  1 
ATOM   2006 H HE2  . PHE C 1 63 ? -21.221 37.137 -27.817 1.00 13.08 ? 1141 PHE B HE2  1 
ATOM   2007 H HZ   . PHE C 1 63 ? -22.025 39.195 -27.148 1.00 12.72 ? 1141 PHE B HZ   1 
ATOM   2008 N N    . VAL C 1 64 ? -17.274 35.812 -21.026 1.00 7.17  ? 1142 VAL B N    1 
ATOM   2009 C CA   . VAL C 1 64 ? -16.468 34.762 -20.427 1.00 9.66  ? 1142 VAL B CA   1 
ATOM   2010 C C    . VAL C 1 64 ? -16.661 34.706 -18.924 1.00 8.99  ? 1142 VAL B C    1 
ATOM   2011 O O    . VAL C 1 64 ? -17.069 35.675 -18.277 1.00 9.50  ? 1142 VAL B O    1 
ATOM   2012 C CB   . VAL C 1 64 ? -14.958 34.918 -20.761 1.00 5.92  ? 1142 VAL B CB   1 
ATOM   2013 C CG1  . VAL C 1 64 ? -14.808 35.231 -22.272 1.00 9.07  ? 1142 VAL B CG1  1 
ATOM   2014 C CG2  . VAL C 1 64 ? -14.319 35.957 -19.854 1.00 10.12 ? 1142 VAL B CG2  1 
ATOM   2015 H H    . VAL C 1 64 ? -17.230 36.574 -20.630 1.00 8.76  ? 1142 VAL B H    1 
ATOM   2016 H HA   . VAL C 1 64 ? -16.790 33.917 -20.779 1.00 11.74 ? 1142 VAL B HA   1 
ATOM   2017 H HB   . VAL C 1 64 ? -14.475 34.094 -20.591 1.00 7.25  ? 1142 VAL B HB   1 
ATOM   2018 H HG11 . VAL C 1 64 ? -13.865 35.235 -22.501 1.00 11.03 ? 1142 VAL B HG11 1 
ATOM   2019 H HG12 . VAL C 1 64 ? -15.269 34.548 -22.783 1.00 11.03 ? 1142 VAL B HG12 1 
ATOM   2020 H HG13 . VAL C 1 64 ? -15.197 36.101 -22.454 1.00 11.03 ? 1142 VAL B HG13 1 
ATOM   2021 H HG21 . VAL C 1 64 ? -13.486 36.255 -20.253 1.00 12.29 ? 1142 VAL B HG21 1 
ATOM   2022 H HG22 . VAL C 1 64 ? -14.926 36.707 -19.756 1.00 12.29 ? 1142 VAL B HG22 1 
ATOM   2023 H HG23 . VAL C 1 64 ? -14.145 35.556 -18.988 1.00 12.29 ? 1142 VAL B HG23 1 
ATOM   2024 N N    . HIS C 1 65 ? -16.345 33.540 -18.381 1.00 6.56  ? 1143 HIS B N    1 
ATOM   2025 C CA   . HIS C 1 65 ? -16.265 33.331 -16.944 1.00 9.81  ? 1143 HIS B CA   1 
ATOM   2026 C C    . HIS C 1 65 ? -14.812 33.137 -16.551 1.00 13.05 ? 1143 HIS B C    1 
ATOM   2027 O O    . HIS C 1 65 ? -14.080 32.386 -17.193 1.00 10.77 ? 1143 HIS B O    1 
ATOM   2028 C CB   . HIS C 1 65 ? -17.032 32.108 -16.477 1.00 13.94 ? 1143 HIS B CB   1 
ATOM   2029 C CG   . HIS C 1 65 ? -18.449 32.406 -16.140 1.00 27.56 ? 1143 HIS B CG   1 
ATOM   2030 N ND1  . HIS C 1 65 ? -19.327 31.446 -15.688 1.00 28.59 ? 1143 HIS B ND1  1 
ATOM   2031 C CD2  . HIS C 1 65 ? -19.149 33.562 -16.198 1.00 23.76 ? 1143 HIS B CD2  1 
ATOM   2032 C CE1  . HIS C 1 65 ? -20.503 32.000 -15.483 1.00 20.01 ? 1143 HIS B CE1  1 
ATOM   2033 N NE2  . HIS C 1 65 ? -20.427 33.277 -15.804 1.00 17.48 ? 1143 HIS B NE2  1 
ATOM   2034 H H    . HIS C 1 65 ? -16.167 32.834 -18.838 1.00 8.02  ? 1143 HIS B H    1 
ATOM   2035 H HA   . HIS C 1 65 ? -16.644 34.111 -16.508 1.00 11.92 ? 1143 HIS B HA   1 
ATOM   2036 H HB2  . HIS C 1 65 ? -17.026 31.443 -17.183 1.00 16.88 ? 1143 HIS B HB2  1 
ATOM   2037 H HB3  . HIS C 1 65 ? -16.604 31.752 -15.682 1.00 16.88 ? 1143 HIS B HB3  1 
ATOM   2038 H HD2  . HIS C 1 65 ? -18.822 34.394 -16.456 1.00 28.66 ? 1143 HIS B HD2  1 
ATOM   2039 H HE1  . HIS C 1 65 ? -21.261 31.564 -15.165 1.00 24.16 ? 1143 HIS B HE1  1 
ATOM   2040 H HE2  . HIS C 1 65 ? -21.076 33.839 -15.771 1.00 21.12 ? 1143 HIS B HE2  1 
ATOM   2041 N N    . ILE C 1 66 ? -14.389 33.784 -15.481 1.00 15.43 ? 1144 ILE B N    1 
ATOM   2042 C CA   . ILE C 1 66 ? -13.002 33.668 -15.027 1.00 17.96 ? 1144 ILE B CA   1 
ATOM   2043 C C    . ILE C 1 66 ? -12.748 32.252 -14.499 1.00 21.58 ? 1144 ILE B C    1 
ATOM   2044 O O    . ILE C 1 66 ? -13.498 31.726 -13.642 1.00 24.39 ? 1144 ILE B O    1 
ATOM   2045 C CB   . ILE C 1 66 ? -12.727 34.735 -13.961 1.00 14.91 ? 1144 ILE B CB   1 
ATOM   2046 C CG1  . ILE C 1 66 ? -12.741 36.162 -14.635 1.00 25.41 ? 1144 ILE B CG1  1 
ATOM   2047 C CG2  . ILE C 1 66 ? -11.350 34.432 -13.228 1.00 25.79 ? 1144 ILE B CG2  1 
ATOM   2048 C CD1  . ILE C 1 66 ? -12.876 37.277 -13.719 1.00 38.64 ? 1144 ILE B CD1  1 
ATOM   2049 H H    . ILE C 1 66 ? -14.878 34.298 -14.995 1.00 18.66 ? 1144 ILE B H    1 
ATOM   2050 H HA   . ILE C 1 66 ? -12.398 33.810 -15.772 1.00 21.70 ? 1144 ILE B HA   1 
ATOM   2051 H HB   . ILE C 1 66 ? -13.423 34.715 -13.285 1.00 18.04 ? 1144 ILE B HB   1 
ATOM   2052 H HG12 . ILE C 1 66 ? -11.907 36.281 -15.116 1.00 30.64 ? 1144 ILE B HG12 1 
ATOM   2053 H HG13 . ILE C 1 66 ? -13.488 36.202 -15.252 1.00 30.64 ? 1144 ILE B HG13 1 
ATOM   2054 H HG21 . ILE C 1 66 ? -11.148 35.161 -12.621 1.00 31.10 ? 1144 ILE B HG21 1 
ATOM   2055 H HG22 . ILE C 1 66 ? -11.432 33.602 -12.732 1.00 31.10 ? 1144 ILE B HG22 1 
ATOM   2056 H HG23 . ILE C 1 66 ? -10.649 34.351 -13.893 1.00 31.10 ? 1144 ILE B HG23 1 
ATOM   2057 H HD11 . ILE C 1 66 ? -12.532 38.078 -14.144 1.00 46.51 ? 1144 ILE B HD11 1 
ATOM   2058 H HD12 . ILE C 1 66 ? -13.813 37.395 -13.501 1.00 46.51 ? 1144 ILE B HD12 1 
ATOM   2059 H HD13 . ILE C 1 66 ? -12.370 37.087 -12.914 1.00 46.51 ? 1144 ILE B HD13 1 
ATOM   2060 N N    . LEU C 1 67 ? -11.683 31.641 -14.982 1.00 13.49 ? 1145 LEU B N    1 
ATOM   2061 C CA   . LEU C 1 67 ? -11.286 30.302 -14.578 1.00 18.38 ? 1145 LEU B CA   1 
ATOM   2062 C C    . LEU C 1 67 ? -9.923  30.297 -13.897 1.00 30.69 ? 1145 LEU B C    1 
ATOM   2063 O O    . LEU C 1 67 ? -9.783  29.747 -12.803 1.00 37.88 ? 1145 LEU B O    1 
ATOM   2064 C CB   . LEU C 1 67 ? -11.281 29.451 -15.839 1.00 22.55 ? 1145 LEU B CB   1 
ATOM   2065 C CG   . LEU C 1 67 ? -12.298 28.371 -16.110 1.00 31.31 ? 1145 LEU B CG   1 
ATOM   2066 C CD1  . LEU C 1 67 ? -11.497 27.542 -17.184 1.00 25.84 ? 1145 LEU B CD1  1 
ATOM   2067 C CD2  . LEU C 1 67 ? -12.691 27.587 -14.951 1.00 34.02 ? 1145 LEU B CD2  1 
ATOM   2068 H H    . LEU C 1 67 ? -11.155 31.991 -15.564 1.00 16.34 ? 1145 LEU B H    1 
ATOM   2069 H HA   . LEU C 1 67 ? -11.908 29.932 -13.934 1.00 22.20 ? 1145 LEU B HA   1 
ATOM   2070 H HB2  . LEU C 1 67 ? -11.357 30.067 -16.585 1.00 27.20 ? 1145 LEU B HB2  1 
ATOM   2071 H HB3  . LEU C 1 67 ? -10.420 29.005 -15.864 1.00 27.20 ? 1145 LEU B HB3  1 
ATOM   2072 H HG   . LEU C 1 67 ? -13.168 28.695 -16.391 1.00 37.72 ? 1145 LEU B HG   1 
ATOM   2073 H HD11 . LEU C 1 67 ? -12.038 26.789 -17.468 1.00 31.15 ? 1145 LEU B HD11 1 
ATOM   2074 H HD12 . LEU C 1 67 ? -11.303 28.114 -17.943 1.00 31.15 ? 1145 LEU B HD12 1 
ATOM   2075 H HD13 . LEU C 1 67 ? -10.671 27.226 -16.787 1.00 31.15 ? 1145 LEU B HD13 1 
ATOM   2076 H HD21 . LEU C 1 67 ? -13.316 26.900 -15.231 1.00 40.97 ? 1145 LEU B HD21 1 
ATOM   2077 H HD22 . LEU C 1 67 ? -11.902 27.177 -14.563 1.00 40.97 ? 1145 LEU B HD22 1 
ATOM   2078 H HD23 . LEU C 1 67 ? -13.113 28.172 -14.302 1.00 40.97 ? 1145 LEU B HD23 1 
ATOM   2079 N N    . SER C 1 68 ? -8.910  30.862 -14.553 1.00 34.18 ? 1146 SER B N    1 
ATOM   2080 C CA   . SER C 1 68 ? -7.505  30.934 -14.136 1.00 35.50 ? 1146 SER B CA   1 
ATOM   2081 C C    . SER C 1 68 ? -7.032  29.742 -13.324 1.00 42.82 ? 1146 SER B C    1 
ATOM   2082 O O    . SER C 1 68 ? -6.532  29.883 -12.209 1.00 69.39 ? 1146 SER B O    1 
ATOM   2083 C CB   . SER C 1 68 ? -7.256  32.208 -13.362 1.00 34.49 ? 1146 SER B CB   1 
ATOM   2084 O OG   . SER C 1 68 ? -7.007  33.220 -14.288 1.00 27.88 ? 1146 SER B OG   1 
ATOM   2085 H H    . SER C 1 68 ? -9.019  31.247 -15.314 1.00 41.17 ? 1146 SER B H    1 
ATOM   2086 H HA   . SER C 1 68 ? -6.985  30.918 -14.955 1.00 42.75 ? 1146 SER B HA   1 
ATOM   2087 H HB2  . SER C 1 68 ? -8.039  32.431 -12.835 1.00 41.54 ? 1146 SER B HB2  1 
ATOM   2088 H HB3  . SER C 1 68 ? -6.487  32.096 -12.782 1.00 41.54 ? 1146 SER B HB3  1 
ATOM   2089 H HG   . SER C 1 68 ? -7.685  33.343 -14.768 1.00 33.60 ? 1146 SER B HG   1 
ATOM   2090 N N    . ASP C 1 69 ? -7.079  28.572 -13.951 1.00 30.41 ? 1147 ASP B N    1 
ATOM   2091 C CA   . ASP C 1 69 ? -6.540  27.373 -13.310 1.00 50.25 ? 1147 ASP B CA   1 
ATOM   2092 C C    . ASP C 1 69 ? -7.074  27.250 -11.876 1.00 56.16 ? 1147 ASP B C    1 
ATOM   2093 O O    . ASP C 1 69 ? -6.545  26.498 -11.048 1.00 65.18 ? 1147 ASP B O    1 
ATOM   2094 C CB   . ASP C 1 69 ? -5.002  27.404 -13.310 1.00 42.89 ? 1147 ASP B CB   1 
ATOM   2095 C CG   . ASP C 1 69 ? -4.383  26.075 -12.869 1.00 60.08 ? 1147 ASP B CG   1 
ATOM   2096 O OD1  . ASP C 1 69 ? -4.164  25.172 -13.732 1.00 46.41 ? 1147 ASP B OD1  1 
ATOM   2097 O OD2  . ASP C 1 69 ? -4.093  25.949 -11.656 1.00 62.75 ? 1147 ASP B OD2  1 
ATOM   2098 H H    . ASP C 1 69 ? -7.411  28.447 -14.735 1.00 36.63 ? 1147 ASP B H    1 
ATOM   2099 H HA   . ASP C 1 69 ? -6.817  26.588 -13.808 1.00 60.44 ? 1147 ASP B HA   1 
ATOM   2100 H HB2  . ASP C 1 69 ? -4.689  27.597 -14.208 1.00 51.62 ? 1147 ASP B HB2  1 
ATOM   2101 H HB3  . ASP C 1 69 ? -4.699  28.093 -12.698 1.00 51.62 ? 1147 ASP B HB3  1 
ATOM   2102 N N    . ILE D 2 2  ? -24.996 39.031 -23.540 1.00 39.70 ? 1700 ILE C N    1 
ATOM   2103 C CA   . ILE D 2 2  ? -26.149 38.925 -24.432 1.00 43.62 ? 1700 ILE C CA   1 
ATOM   2104 C C    . ILE D 2 2  ? -25.948 39.969 -25.547 1.00 36.72 ? 1700 ILE C C    1 
ATOM   2105 O O    . ILE D 2 2  ? -25.912 39.619 -26.736 1.00 42.87 ? 1700 ILE C O    1 
ATOM   2106 C CB   . ILE D 2 2  ? -27.476 39.108 -23.674 1.00 44.27 ? 1700 ILE C CB   1 
ATOM   2107 H HA   . ILE D 2 2  ? -26.209 38.040 -24.826 1.00 52.49 ? 1700 ILE C HA   1 
ATOM   2108 N N    . LYS D 2 3  ? -25.819 41.243 -25.155 1.00 33.40 ? 1701 LYS C N    1 
ATOM   2109 C CA   . LYS D 2 3  ? -25.465 42.341 -26.057 1.00 27.63 ? 1701 LYS C CA   1 
ATOM   2110 C C    . LYS D 2 3  ? -23.952 42.569 -25.956 1.00 23.76 ? 1701 LYS C C    1 
ATOM   2111 O O    . LYS D 2 3  ? -23.399 42.618 -24.854 1.00 23.24 ? 1701 LYS C O    1 
ATOM   2112 C CB   . LYS D 2 3  ? -26.219 43.625 -25.690 1.00 24.11 ? 1701 LYS C CB   1 
ATOM   2113 H H    . LYS D 2 3  ? -25.936 41.503 -24.344 1.00 40.22 ? 1701 LYS C H    1 
ATOM   2114 H HA   . LYS D 2 3  ? -25.700 42.114 -26.970 1.00 33.30 ? 1701 LYS C HA   1 
ATOM   2115 N N    . LYS D 2 4  ? -23.294 42.702 -27.074 1.00 16.32 ? 1702 LYS C N    1 
ATOM   2116 C CA   . LYS D 2 4  ? -21.842 42.939 -27.048 1.00 14.69 ? 1702 LYS C CA   1 
ATOM   2117 C C    . LYS D 2 4  ? -21.546 44.414 -26.792 1.00 12.02 ? 1702 LYS C C    1 
ATOM   2118 O O    . LYS D 2 4  ? -22.092 45.282 -27.472 1.00 17.84 ? 1702 LYS C O    1 
ATOM   2119 C CB   . LYS D 2 4  ? -21.259 42.485 -28.363 1.00 15.63 ? 1702 LYS C CB   1 
ATOM   2120 C CG   . LYS D 2 4  ? -19.794 42.408 -28.459 1.00 16.17 ? 1702 LYS C CG   1 
ATOM   2121 C CD   . LYS D 2 4  ? -19.438 41.953 -29.869 1.00 11.95 ? 1702 LYS C CD   1 
ATOM   2122 C CE   . LYS D 2 4  ? -19.746 40.484 -30.099 1.00 13.08 ? 1702 LYS C CE   1 
ATOM   2123 N NZ   . LYS D 2 4  ? -19.169 40.002 -31.387 1.00 14.57 ? 1702 LYS C NZ   1 
ATOM   2124 H H    . LYS D 2 4  ? -23.642 42.663 -27.859 1.00 19.73 ? 1702 LYS C H    1 
ATOM   2125 H HA   . LYS D 2 4  ? -21.422 42.444 -26.327 1.00 17.77 ? 1702 LYS C HA   1 
ATOM   2126 H HB2  . LYS D 2 4  ? -21.600 41.596 -28.549 1.00 18.90 ? 1702 LYS C HB2  1 
ATOM   2127 H HB3  . LYS D 2 4  ? -21.554 43.104 -29.049 1.00 18.90 ? 1702 LYS C HB3  1 
ATOM   2128 H HG2  . LYS D 2 4  ? -19.402 43.280 -28.296 1.00 19.55 ? 1702 LYS C HG2  1 
ATOM   2129 H HG3  . LYS D 2 4  ? -19.450 41.765 -27.820 1.00 19.55 ? 1702 LYS C HG3  1 
ATOM   2130 H HD2  . LYS D 2 4  ? -19.950 42.472 -30.509 1.00 14.49 ? 1702 LYS C HD2  1 
ATOM   2131 H HD3  . LYS D 2 4  ? -18.488 42.089 -30.016 1.00 14.49 ? 1702 LYS C HD3  1 
ATOM   2132 H HE2  . LYS D 2 4  ? -19.364 39.959 -29.378 1.00 15.84 ? 1702 LYS C HE2  1 
ATOM   2133 H HE3  . LYS D 2 4  ? -20.707 40.358 -30.128 1.00 15.84 ? 1702 LYS C HE3  1 
ATOM   2134 H HZ1  . LYS D 2 4  ? -19.519 40.458 -32.067 1.00 17.63 ? 1702 LYS C HZ1  1 
ATOM   2135 H HZ2  . LYS D 2 4  ? -18.287 40.116 -31.388 1.00 17.63 ? 1702 LYS C HZ2  1 
ATOM   2136 H HZ3  . LYS D 2 4  ? -19.349 39.137 -31.497 1.00 17.63 ? 1702 LYS C HZ3  1 
ATOM   2137 N N    . PRO D 2 5  ? -20.706 44.746 -25.824 1.00 18.27 ? 1703 PRO C N    1 
ATOM   2138 C CA   . PRO D 2 5  ? -20.355 46.153 -25.632 1.00 16.37 ? 1703 PRO C CA   1 
ATOM   2139 C C    . PRO D 2 5  ? -19.596 46.679 -26.842 1.00 22.77 ? 1703 PRO C C    1 
ATOM   2140 O O    . PRO D 2 5  ? -18.928 45.936 -27.564 1.00 20.11 ? 1703 PRO C O    1 
ATOM   2141 C CB   . PRO D 2 5  ? -19.489 46.128 -24.374 1.00 17.69 ? 1703 PRO C CB   1 
ATOM   2142 C CG   . PRO D 2 5  ? -18.893 44.707 -24.382 1.00 20.30 ? 1703 PRO C CG   1 
ATOM   2143 C CD   . PRO D 2 5  ? -20.015 43.862 -24.876 1.00 15.60 ? 1703 PRO C CD   1 
ATOM   2144 H HA   . PRO D 2 5  ? -21.136 46.705 -25.468 1.00 19.79 ? 1703 PRO C HA   1 
ATOM   2145 H HB2  . PRO D 2 5  ? -18.794 46.802 -24.430 1.00 21.38 ? 1703 PRO C HB2  1 
ATOM   2146 H HB3  . PRO D 2 5  ? -20.034 46.278 -23.586 1.00 21.38 ? 1703 PRO C HB3  1 
ATOM   2147 H HG2  . PRO D 2 5  ? -18.131 44.665 -24.980 1.00 24.51 ? 1703 PRO C HG2  1 
ATOM   2148 H HG3  . PRO D 2 5  ? -18.627 44.450 -23.486 1.00 24.51 ? 1703 PRO C HG3  1 
ATOM   2149 H HD2  . PRO D 2 5  ? -19.680 43.069 -25.323 1.00 18.86 ? 1703 PRO C HD2  1 
ATOM   2150 H HD3  . PRO D 2 5  ? -20.603 43.608 -24.148 1.00 18.86 ? 1703 PRO C HD3  1 
ATOM   2151 N N    . VAL D 2 6  ? -19.661 47.987 -27.034 1.00 18.21 ? 1704 VAL C N    1 
ATOM   2152 C CA   . VAL D 2 6  ? -19.047 48.597 -28.204 1.00 18.57 ? 1704 VAL C CA   1 
ATOM   2153 C C    . VAL D 2 6  ? -17.543 48.659 -27.991 1.00 13.91 ? 1704 VAL C C    1 
ATOM   2154 O O    . VAL D 2 6  ? -17.063 48.704 -26.850 1.00 15.75 ? 1704 VAL C O    1 
ATOM   2155 C CB   . VAL D 2 6  ? -19.633 50.001 -28.492 1.00 22.38 ? 1704 VAL C CB   1 
ATOM   2156 C CG1  . VAL D 2 6  ? -21.098 49.899 -28.887 1.00 23.00 ? 1704 VAL C CG1  1 
ATOM   2157 C CG2  . VAL D 2 6  ? -19.420 50.924 -27.311 1.00 25.51 ? 1704 VAL C CG2  1 
ATOM   2158 H H    . VAL D 2 6  ? -20.052 48.541 -26.505 1.00 21.99 ? 1704 VAL C H    1 
ATOM   2159 H HA   . VAL D 2 6  ? -19.238 48.044 -28.977 1.00 22.43 ? 1704 VAL C HA   1 
ATOM   2160 H HB   . VAL D 2 6  ? -19.163 50.395 -29.244 1.00 27.01 ? 1704 VAL C HB   1 
ATOM   2161 H HG11 . VAL D 2 6  ? -21.438 50.788 -29.074 1.00 27.75 ? 1704 VAL C HG11 1 
ATOM   2162 H HG12 . VAL D 2 6  ? -21.174 49.342 -29.678 1.00 27.75 ? 1704 VAL C HG12 1 
ATOM   2163 H HG13 . VAL D 2 6  ? -21.595 49.502 -28.155 1.00 27.75 ? 1704 VAL C HG13 1 
ATOM   2164 H HG21 . VAL D 2 6  ? -19.731 51.813 -27.545 1.00 30.76 ? 1704 VAL C HG21 1 
ATOM   2165 H HG22 . VAL D 2 6  ? -19.923 50.587 -26.553 1.00 30.76 ? 1704 VAL C HG22 1 
ATOM   2166 H HG23 . VAL D 2 6  ? -18.475 50.950 -27.097 1.00 30.76 ? 1704 VAL C HG23 1 
ATOM   2167 N N    . ARG D 2 7  ? -16.793 48.613 -29.102 1.00 14.19 ? 1705 ARG C N    1 
ATOM   2168 C CA   . ARG D 2 7  ? -15.356 48.860 -29.068 1.00 15.88 ? 1705 ARG C CA   1 
ATOM   2169 C C    . ARG D 2 7  ? -15.148 50.358 -28.956 1.00 17.97 ? 1705 ARG C C    1 
ATOM   2170 O O    . ARG D 2 7  ? -15.806 51.125 -29.662 1.00 23.08 ? 1705 ARG C O    1 
ATOM   2171 C CB   . ARG D 2 7  ? -14.664 48.331 -30.321 1.00 12.17 ? 1705 ARG C CB   1 
ATOM   2172 C CG   . ARG D 2 7  ? -14.800 46.859 -30.572 1.00 7.45  ? 1705 ARG C CG   1 
ATOM   2173 C CD   . ARG D 2 7  ? -13.833 46.019 -29.732 1.00 9.33  ? 1705 ARG C CD   1 
ATOM   2174 N NE   . ARG D 2 7  ? -12.443 46.424 -29.887 1.00 8.13  ? 1705 ARG C NE   1 
ATOM   2175 C CZ   . ARG D 2 7  ? -11.620 45.989 -30.825 1.00 8.33  ? 1705 ARG C CZ   1 
ATOM   2176 N NH1  . ARG D 2 7  ? -12.045 45.257 -31.832 1.00 9.04  ? 1705 ARG C NH1  1 
ATOM   2177 N NH2  . ARG D 2 7  ? -10.347 46.358 -30.786 1.00 7.87  ? 1705 ARG C NH2  1 
ATOM   2178 H H    . ARG D 2 7  ? -17.099 48.439 -29.887 1.00 17.18 ? 1705 ARG C H    1 
ATOM   2179 H HA   . ARG D 2 7  ? -14.958 48.401 -28.312 1.00 19.20 ? 1705 ARG C HA   1 
ATOM   2180 H HB2  . ARG D 2 7  ? -15.038 48.789 -31.091 1.00 14.75 ? 1705 ARG C HB2  1 
ATOM   2181 H HB3  . ARG D 2 7  ? -13.716 48.524 -30.249 1.00 14.75 ? 1705 ARG C HB3  1 
ATOM   2182 H HG2  . ARG D 2 7  ? -15.703 46.584 -30.353 1.00 9.09  ? 1705 ARG C HG2  1 
ATOM   2183 H HG3  . ARG D 2 7  ? -14.616 46.680 -31.508 1.00 9.09  ? 1705 ARG C HG3  1 
ATOM   2184 H HD2  . ARG D 2 7  ? -14.068 46.110 -28.796 1.00 11.34 ? 1705 ARG C HD2  1 
ATOM   2185 H HD3  . ARG D 2 7  ? -13.905 45.090 -30.003 1.00 11.34 ? 1705 ARG C HD3  1 
ATOM   2186 H HE   . ARG D 2 7  ? -12.132 46.992 -29.321 1.00 9.91  ? 1705 ARG C HE   1 
ATOM   2187 H HH11 . ARG D 2 7  ? -12.878 45.049 -31.891 1.00 11.00 ? 1705 ARG C HH11 1 
ATOM   2188 H HH12 . ARG D 2 7  ? -11.491 44.985 -32.431 1.00 11.00 ? 1705 ARG C HH12 1 
ATOM   2189 H HH21 . ARG D 2 7  ? -10.067 46.872 -30.156 1.00 9.59  ? 1705 ARG C HH21 1 
ATOM   2190 H HH22 . ARG D 2 7  ? -9.800  46.082 -31.390 1.00 9.59  ? 1705 ARG C HH22 1 
ATOM   2191 N N    . ARG D 2 8  ? -14.271 50.778 -28.053 1.00 20.30 ? 1706 ARG C N    1 
ATOM   2192 C CA   . ARG D 2 8  ? -13.882 52.193 -27.953 1.00 25.38 ? 1706 ARG C CA   1 
ATOM   2193 C C    . ARG D 2 8  ? -12.375 52.460 -28.127 1.00 30.32 ? 1706 ARG C C    1 
ATOM   2194 O O    . ARG D 2 8  ? -11.692 51.717 -28.838 1.00 36.54 ? 1706 ARG C O    1 
ATOM   2195 C CB   . ARG D 2 8  ? -14.348 52.758 -26.618 1.00 26.99 ? 1706 ARG C CB   1 
ATOM   2196 C CG   . ARG D 2 8  ? -15.649 53.514 -26.760 1.00 31.67 ? 1706 ARG C CG   1 
ATOM   2197 C CD   . ARG D 2 8  ? -16.481 53.508 -25.500 1.00 25.78 ? 1706 ARG C CD   1 
ATOM   2198 N NE   . ARG D 2 8  ? -15.707 54.009 -24.394 1.00 28.98 ? 1706 ARG C NE   1 
ATOM   2199 C CZ   . ARG D 2 8  ? -16.216 54.412 -23.247 1.00 21.91 ? 1706 ARG C CZ   1 
ATOM   2200 N NH1  . ARG D 2 8  ? -17.518 54.440 -23.047 1.00 18.23 ? 1706 ARG C NH1  1 
ATOM   2201 N NH2  . ARG D 2 8  ? -15.395 54.796 -22.277 1.00 18.39 ? 1706 ARG C NH2  1 
ATOM   2202 H H    . ARG D 2 8  ? -13.881 50.266 -27.482 1.00 24.51 ? 1706 ARG C H    1 
ATOM   2203 H HA   . ARG D 2 8  ? -14.315 52.658 -28.686 1.00 30.60 ? 1706 ARG C HA   1 
ATOM   2204 H HB2  . ARG D 2 8  ? -14.484 52.029 -25.992 1.00 32.53 ? 1706 ARG C HB2  1 
ATOM   2205 H HB3  . ARG D 2 8  ? -13.675 53.368 -26.276 1.00 32.53 ? 1706 ARG C HB3  1 
ATOM   2206 H HG2  . ARG D 2 8  ? -15.453 54.437 -26.984 1.00 38.15 ? 1706 ARG C HG2  1 
ATOM   2207 H HG3  . ARG D 2 8  ? -16.174 53.105 -27.466 1.00 38.15 ? 1706 ARG C HG3  1 
ATOM   2208 H HD2  . ARG D 2 8  ? -17.257 54.078 -25.620 1.00 31.08 ? 1706 ARG C HD2  1 
ATOM   2209 H HD3  . ARG D 2 8  ? -16.762 52.602 -25.299 1.00 31.08 ? 1706 ARG C HD3  1 
ATOM   2210 H HE   . ARG D 2 8  ? -14.853 54.048 -24.488 1.00 34.93 ? 1706 ARG C HE   1 
ATOM   2211 H HH11 . ARG D 2 8  ? -18.054 54.193 -23.672 1.00 22.02 ? 1706 ARG C HH11 1 
ATOM   2212 H HH12 . ARG D 2 8  ? -17.831 54.706 -22.292 1.00 22.02 ? 1706 ARG C HH12 1 
ATOM   2213 H HH21 . ARG D 2 8  ? -14.544 54.781 -22.403 1.00 22.21 ? 1706 ARG C HH21 1 
ATOM   2214 H HH22 . ARG D 2 8  ? -15.713 55.062 -21.524 1.00 22.21 ? 1706 ARG C HH22 1 
ATOM   2215 N N    . LYS E 1 8  ? -29.551 0.466  2.463   1.00 49.15 ? 1086 LYS D N    1 
ATOM   2216 C CA   . LYS E 1 8  ? -28.663 1.312  1.687   1.00 51.23 ? 1086 LYS D CA   1 
ATOM   2217 C C    . LYS E 1 8  ? -27.864 2.412  2.557   1.00 43.59 ? 1086 LYS D C    1 
ATOM   2218 O O    . LYS E 1 8  ? -28.086 2.593  3.781   1.00 44.83 ? 1086 LYS D O    1 
ATOM   2219 C CB   . LYS E 1 8  ? -29.386 2.054  0.549   1.00 55.91 ? 1086 LYS D CB   1 
ATOM   2220 C CG   . LYS E 1 8  ? -28.777 1.888  -0.945  1.00 63.29 ? 1086 LYS D CG   1 
ATOM   2221 C CD   . LYS E 1 8  ? -28.457 3.521  -1.110  1.00 75.11 ? 1086 LYS D CD   1 
ATOM   2222 C CE   . LYS E 1 8  ? -29.554 4.274  -2.049  1.00 69.74 ? 1086 LYS D CE   1 
ATOM   2223 N NZ   . LYS E 1 8  ? -30.206 5.474  -1.204  1.00 54.73 ? 1086 LYS D NZ   1 
ATOM   2224 H HA   . LYS E 1 8  ? -28.018 0.694  1.308   1.00 61.62 ? 1086 LYS D HA   1 
ATOM   2225 H HB2  . LYS E 1 8  ? -30.301 1.733  0.517   1.00 67.23 ? 1086 LYS D HB2  1 
ATOM   2226 H HB3  . LYS E 1 8  ? -29.374 3.001  0.755   1.00 67.23 ? 1086 LYS D HB3  1 
ATOM   2227 H HG2  . LYS E 1 8  ? -27.975 1.343  -0.976  1.00 76.09 ? 1086 LYS D HG2  1 
ATOM   2228 H HG3  . LYS E 1 8  ? -29.423 1.565  -1.592  1.00 76.09 ? 1086 LYS D HG3  1 
ATOM   2229 H HD2  . LYS E 1 8  ? -28.472 3.938  -0.234  1.00 90.28 ? 1086 LYS D HD2  1 
ATOM   2230 H HD3  . LYS E 1 8  ? -27.583 3.635  -1.516  1.00 90.28 ? 1086 LYS D HD3  1 
ATOM   2231 H HE2  . LYS E 1 8  ? -29.123 4.639  -2.838  1.00 83.84 ? 1086 LYS D HE2  1 
ATOM   2232 H HE3  . LYS E 1 8  ? -30.252 3.653  -2.310  1.00 83.84 ? 1086 LYS D HE3  1 
ATOM   2233 H HZ1  . LYS E 1 8  ? -29.675 5.692  -0.524  1.00 65.83 ? 1086 LYS D HZ1  1 
ATOM   2234 H HZ2  . LYS E 1 8  ? -30.318 6.187  -1.724  1.00 65.83 ? 1086 LYS D HZ2  1 
ATOM   2235 H HZ3  . LYS E 1 8  ? -30.998 5.224  -0.882  1.00 65.83 ? 1086 LYS D HZ3  1 
ATOM   2236 N N    . VAL E 1 9  ? -26.948 3.050  1.826   1.00 40.44 ? 1087 VAL D N    1 
ATOM   2237 C CA   . VAL E 1 9  ? -26.371 4.365  2.139   1.00 35.94 ? 1087 VAL D CA   1 
ATOM   2238 C C    . VAL E 1 9  ? -27.324 5.530  1.784   1.00 22.05 ? 1087 VAL D C    1 
ATOM   2239 O O    . VAL E 1 9  ? -27.898 5.619  0.689   1.00 21.22 ? 1087 VAL D O    1 
ATOM   2240 C CB   . VAL E 1 9  ? -25.031 4.580  1.401   1.00 25.98 ? 1087 VAL D CB   1 
ATOM   2241 C CG1  . VAL E 1 9  ? -24.418 5.862  1.859   1.00 23.59 ? 1087 VAL D CG1  1 
ATOM   2242 C CG2  . VAL E 1 9  ? -24.173 3.336  1.626   1.00 29.74 ? 1087 VAL D CG2  1 
ATOM   2243 H H    . VAL E 1 9  ? -26.624 2.724  1.099   1.00 48.67 ? 1087 VAL D H    1 
ATOM   2244 H HA   . VAL E 1 9  ? -26.241 4.367  3.101   1.00 43.28 ? 1087 VAL D HA   1 
ATOM   2245 H HB   . VAL E 1 9  ? -25.133 4.679  0.442   1.00 31.32 ? 1087 VAL D HB   1 
ATOM   2246 H HG11 . VAL E 1 9  ? -23.489 5.884  1.582   1.00 28.45 ? 1087 VAL D HG11 1 
ATOM   2247 H HG12 . VAL E 1 9  ? -24.900 6.603  1.459   1.00 28.45 ? 1087 VAL D HG12 1 
ATOM   2248 H HG13 . VAL E 1 9  ? -24.476 5.912  2.826   1.00 28.45 ? 1087 VAL D HG13 1 
ATOM   2249 H HG21 . VAL E 1 9  ? -23.252 3.543  1.403   1.00 35.83 ? 1087 VAL D HG21 1 
ATOM   2250 H HG22 . VAL E 1 9  ? -24.236 3.072  2.557   1.00 35.83 ? 1087 VAL D HG22 1 
ATOM   2251 H HG23 . VAL E 1 9  ? -24.498 2.621  1.057   1.00 35.83 ? 1087 VAL D HG23 1 
ATOM   2252 N N    . ARG E 1 10 ? -27.450 6.472  2.689   1.00 18.36 ? 1088 ARG D N    1 
ATOM   2253 C CA   . ARG E 1 10 ? -28.229 7.671  2.441   1.00 17.30 ? 1088 ARG D CA   1 
ATOM   2254 C C    . ARG E 1 10 ? -27.397 8.939  2.526   1.00 15.33 ? 1088 ARG D C    1 
ATOM   2255 O O    . ARG E 1 10 ? -27.636 9.870  1.751   1.00 13.95 ? 1088 ARG D O    1 
ATOM   2256 C CB   . ARG E 1 10 ? -29.417 7.785  3.423   1.00 14.32 ? 1088 ARG D CB   1 
ATOM   2257 C CG   . ARG E 1 10 ? -30.263 9.057  3.121   1.00 23.48 ? 1088 ARG D CG   1 
ATOM   2258 C CD   . ARG E 1 10 ? -31.544 9.176  3.985   1.00 17.51 ? 1088 ARG D CD   1 
ATOM   2259 N NE   . ARG E 1 10 ? -31.220 9.239  5.405   1.00 15.81 ? 1088 ARG D NE   1 
ATOM   2260 C CZ   . ARG E 1 10 ? -31.081 10.344 6.120   1.00 13.21 ? 1088 ARG D CZ   1 
ATOM   2261 N NH1  . ARG E 1 10 ? -31.294 11.536 5.600   1.00 12.43 ? 1088 ARG D NH1  1 
ATOM   2262 N NH2  . ARG E 1 10 ? -30.661 10.251 7.381   1.00 11.07 ? 1088 ARG D NH2  1 
ATOM   2263 H H    . ARG E 1 10 ? -27.089 6.443  3.470   1.00 22.17 ? 1088 ARG D H    1 
ATOM   2264 H HA   . ARG E 1 10 ? -28.604 7.604  1.549   1.00 20.90 ? 1088 ARG D HA   1 
ATOM   2265 H HB2  . ARG E 1 10 ? -29.988 7.006  3.332   1.00 17.33 ? 1088 ARG D HB2  1 
ATOM   2266 H HB3  . ARG E 1 10 ? -29.081 7.846  4.331   1.00 17.33 ? 1088 ARG D HB3  1 
ATOM   2267 H HG2  . ARG E 1 10 ? -29.719 9.842  3.291   1.00 28.32 ? 1088 ARG D HG2  1 
ATOM   2268 H HG3  . ARG E 1 10 ? -30.536 9.038  2.191   1.00 28.32 ? 1088 ARG D HG3  1 
ATOM   2269 H HD2  . ARG E 1 10 ? -32.021 9.985  3.744   1.00 21.16 ? 1088 ARG D HD2  1 
ATOM   2270 H HD3  . ARG E 1 10 ? -32.107 8.401  3.834   1.00 21.16 ? 1088 ARG D HD3  1 
ATOM   2271 H HE   . ARG E 1 10 ? -31.109 8.491  5.815   1.00 19.12 ? 1088 ARG D HE   1 
ATOM   2272 H HH11 . ARG E 1 10 ? -31.530 11.610 4.776   1.00 15.06 ? 1088 ARG D HH11 1 
ATOM   2273 H HH12 . ARG E 1 10 ? -31.197 12.240 6.084   1.00 15.06 ? 1088 ARG D HH12 1 
ATOM   2274 H HH21 . ARG E 1 10 ? -30.484 9.480  7.720   1.00 13.44 ? 1088 ARG D HH21 1 
ATOM   2275 H HH22 . ARG E 1 10 ? -30.566 10.961 7.857   1.00 13.44 ? 1088 ARG D HH22 1 
ATOM   2276 N N    . ARG E 1 11 ? -26.474 9.041  3.481   1.00 14.27 ? 1089 ARG D N    1 
ATOM   2277 C CA   . ARG E 1 11 ? -25.663 10.239 3.640   1.00 14.03 ? 1089 ARG D CA   1 
ATOM   2278 C C    . ARG E 1 11 ? -24.197 9.857  3.536   1.00 14.54 ? 1089 ARG D C    1 
ATOM   2279 O O    . ARG E 1 11 ? -23.767 8.827  4.065   1.00 17.70 ? 1089 ARG D O    1 
ATOM   2280 C CB   . ARG E 1 11 ? -25.936 10.957 4.965   1.00 14.24 ? 1089 ARG D CB   1 
ATOM   2281 C CG   . ARG E 1 11 ? -27.384 11.303 5.192   1.00 18.23 ? 1089 ARG D CG   1 
ATOM   2282 C CD   . ARG E 1 11 ? -27.645 11.943 6.549   1.00 17.13 ? 1089 ARG D CD   1 
ATOM   2283 N NE   . ARG E 1 11 ? -27.069 13.272 6.721   1.00 11.86 ? 1089 ARG D NE   1 
ATOM   2284 C CZ   . ARG E 1 11 ? -26.091 13.532 7.571   1.00 17.45 ? 1089 ARG D CZ   1 
ATOM   2285 N NH1  . ARG E 1 11 ? -25.536 12.574 8.282   1.00 16.80 ? 1089 ARG D NH1  1 
ATOM   2286 N NH2  . ARG E 1 11 ? -25.694 14.788 7.744   1.00 19.24 ? 1089 ARG D NH2  1 
ATOM   2287 H H    . ARG E 1 11 ? -26.301 8.422  4.052   1.00 17.27 ? 1089 ARG D H    1 
ATOM   2288 H HA   . ARG E 1 11 ? -25.875 10.868 2.933   1.00 16.99 ? 1089 ARG D HA   1 
ATOM   2289 H HB2  . ARG E 1 11 ? -25.653 10.383 5.694   1.00 17.23 ? 1089 ARG D HB2  1 
ATOM   2290 H HB3  . ARG E 1 11 ? -25.431 11.785 4.979   1.00 17.23 ? 1089 ARG D HB3  1 
ATOM   2291 H HG2  . ARG E 1 11 ? -27.668 11.929 4.508   1.00 22.02 ? 1089 ARG D HG2  1 
ATOM   2292 H HG3  . ARG E 1 11 ? -27.913 10.491 5.139   1.00 22.02 ? 1089 ARG D HG3  1 
ATOM   2293 H HD2  . ARG E 1 11 ? -28.603 12.023 6.673   1.00 20.71 ? 1089 ARG D HD2  1 
ATOM   2294 H HD3  . ARG E 1 11 ? -27.268 11.371 7.237   1.00 20.71 ? 1089 ARG D HD3  1 
ATOM   2295 H HE   . ARG E 1 11 ? -27.380 13.917 6.245   1.00 14.37 ? 1089 ARG D HE   1 
ATOM   2296 H HH11 . ARG E 1 11 ? -25.808 11.762 8.196   1.00 20.31 ? 1089 ARG D HH11 1 
ATOM   2297 H HH12 . ARG E 1 11 ? -24.901 12.759 8.831   1.00 20.31 ? 1089 ARG D HH12 1 
ATOM   2298 H HH21 . ARG E 1 11 ? -26.072 15.423 7.304   1.00 23.23 ? 1089 ARG D HH21 1 
ATOM   2299 H HH22 . ARG E 1 11 ? -25.058 14.966 8.295   1.00 23.23 ? 1089 ARG D HH22 1 
ATOM   2300 N N    . VAL E 1 12 ? -23.447 10.651 2.785   1.00 12.82 ? 1090 VAL D N    1 
ATOM   2301 C CA   . VAL E 1 12 ? -22.013 10.451 2.654   1.00 9.12  ? 1090 VAL D CA   1 
ATOM   2302 C C    . VAL E 1 12 ? -21.331 11.793 2.869   1.00 9.15  ? 1090 VAL D C    1 
ATOM   2303 O O    . VAL E 1 12 ? -21.949 12.857 2.776   1.00 7.73  ? 1090 VAL D O    1 
ATOM   2304 C CB   . VAL E 1 12 ? -21.598 9.819  1.312   1.00 7.32  ? 1090 VAL D CB   1 
ATOM   2305 C CG1  . VAL E 1 12 ? -22.130 8.431  1.201   1.00 10.59 ? 1090 VAL D CG1  1 
ATOM   2306 C CG2  . VAL E 1 12 ? -22.083 10.637 0.149   1.00 8.53  ? 1090 VAL D CG2  1 
ATOM   2307 H H    . VAL E 1 12 ? -23.750 11.320 2.338   1.00 15.53 ? 1090 VAL D H    1 
ATOM   2308 H HA   . VAL E 1 12 ? -21.715 9.840  3.346   1.00 11.09 ? 1090 VAL D HA   1 
ATOM   2309 H HB   . VAL E 1 12 ? -20.629 9.791  1.283   1.00 8.93  ? 1090 VAL D HB   1 
ATOM   2310 H HG11 . VAL E 1 12 ? -21.605 7.942  0.548   1.00 12.86 ? 1090 VAL D HG11 1 
ATOM   2311 H HG12 . VAL E 1 12 ? -22.067 7.998  2.067   1.00 12.86 ? 1090 VAL D HG12 1 
ATOM   2312 H HG13 . VAL E 1 12 ? -23.057 8.469  0.918   1.00 12.86 ? 1090 VAL D HG13 1 
ATOM   2313 H HG21 . VAL E 1 12 ? -21.979 10.121 -0.666  1.00 10.39 ? 1090 VAL D HG21 1 
ATOM   2314 H HG22 . VAL E 1 12 ? -23.018 10.856 0.284   1.00 10.39 ? 1090 VAL D HG22 1 
ATOM   2315 H HG23 . VAL E 1 12 ? -21.557 11.451 0.095   1.00 10.39 ? 1090 VAL D HG23 1 
ATOM   2316 N N    . LYS E 1 13 ? -20.046 11.723 3.220   1.00 9.34  ? 1091 LYS D N    1 
ATOM   2317 C CA   . LYS E 1 13 ? -19.218 12.900 3.407   1.00 8.23  ? 1091 LYS D CA   1 
ATOM   2318 C C    . LYS E 1 13 ? -18.069 12.801 2.413   1.00 8.91  ? 1091 LYS D C    1 
ATOM   2319 O O    . LYS E 1 13 ? -17.432 11.751 2.295   1.00 8.28  ? 1091 LYS D O    1 
ATOM   2320 C CB   . LYS E 1 13 ? -18.681 13.017 4.839   1.00 11.24 ? 1091 LYS D CB   1 
ATOM   2321 C CG   . LYS E 1 13 ? -18.032 14.383 5.071   1.00 12.15 ? 1091 LYS D CG   1 
ATOM   2322 C CD   . LYS E 1 13 ? -18.130 14.847 6.510   1.00 25.80 ? 1091 LYS D CD   1 
ATOM   2323 C CE   . LYS E 1 13 ? -17.172 14.048 7.419   1.00 32.38 ? 1091 LYS D CE   1 
ATOM   2324 N NZ   . LYS E 1 13 ? -17.777 13.628 8.742   1.00 49.67 ? 1091 LYS D NZ   1 
ATOM   2325 H H    . LYS E 1 13 ? -19.627 10.984 3.358   1.00 11.35 ? 1091 LYS D H    1 
ATOM   2326 H HA   . LYS E 1 13 ? -19.736 13.703 3.240   1.00 10.02 ? 1091 LYS D HA   1 
ATOM   2327 H HB2  . LYS E 1 13 ? -19.413 12.913 5.467   1.00 13.63 ? 1091 LYS D HB2  1 
ATOM   2328 H HB3  . LYS E 1 13 ? -18.014 12.329 4.990   1.00 13.63 ? 1091 LYS D HB3  1 
ATOM   2329 H HG2  . LYS E 1 13 ? -17.092 14.329 4.838   1.00 14.72 ? 1091 LYS D HG2  1 
ATOM   2330 H HG3  . LYS E 1 13 ? -18.474 15.042 4.514   1.00 14.72 ? 1091 LYS D HG3  1 
ATOM   2331 H HD2  . LYS E 1 13 ? -17.892 15.786 6.563   1.00 31.10 ? 1091 LYS D HD2  1 
ATOM   2332 H HD3  . LYS E 1 13 ? -19.037 14.716 6.830   1.00 31.10 ? 1091 LYS D HD3  1 
ATOM   2333 H HE2  . LYS E 1 13 ? -16.901 13.242 6.951   1.00 39.00 ? 1091 LYS D HE2  1 
ATOM   2334 H HE3  . LYS E 1 13 ? -16.396 14.597 7.611   1.00 39.00 ? 1091 LYS D HE3  1 
ATOM   2335 H HZ1  . LYS E 1 13 ? -17.179 13.174 9.219   1.00 59.75 ? 1091 LYS D HZ1  1 
ATOM   2336 H HZ2  . LYS E 1 13 ? -18.028 14.347 9.203   1.00 59.75 ? 1091 LYS D HZ2  1 
ATOM   2337 H HZ3  . LYS E 1 13 ? -18.488 13.112 8.602   1.00 59.75 ? 1091 LYS D HZ3  1 
ATOM   2338 N N    . THR E 1 14 ? -17.837 13.865 1.664   1.00 9.02  ? 1092 THR D N    1 
ATOM   2339 C CA   . THR E 1 14 ? -16.790 13.830 0.657   1.00 8.20  ? 1092 THR D CA   1 
ATOM   2340 C C    . THR E 1 14 ? -15.427 13.954 1.314   1.00 8.30  ? 1092 THR D C    1 
ATOM   2341 O O    . THR E 1 14 ? -15.235 14.777 2.203   1.00 4.80  ? 1092 THR D O    1 
ATOM   2342 C CB   . THR E 1 14 ? -16.960 14.954 -0.354  1.00 5.37  ? 1092 THR D CB   1 
ATOM   2343 O OG1  . THR E 1 14 ? -16.822 16.212 0.314   1.00 8.44  ? 1092 THR D OG1  1 
ATOM   2344 C CG2  . THR E 1 14 ? -18.356 14.852 -1.067  1.00 8.28  ? 1092 THR D CG2  1 
ATOM   2345 H H    . THR E 1 14 ? -18.266 14.609 1.717   1.00 10.97 ? 1092 THR D H    1 
ATOM   2346 H HA   . THR E 1 14 ? -16.842 12.986 0.182   1.00 9.98  ? 1092 THR D HA   1 
ATOM   2347 H HB   . THR E 1 14 ? -16.281 14.888 -1.043  1.00 6.60  ? 1092 THR D HB   1 
ATOM   2348 H HG1  . THR E 1 14 ? -16.819 16.837 -0.247  1.00 10.27 ? 1092 THR D HG1  1 
ATOM   2349 H HG21 . THR E 1 14 ? -18.567 15.692 -1.504  1.00 10.08 ? 1092 THR D HG21 1 
ATOM   2350 H HG22 . THR E 1 14 ? -18.338 14.146 -1.732  1.00 10.08 ? 1092 THR D HG22 1 
ATOM   2351 H HG23 . THR E 1 14 ? -19.047 14.653 -0.416  1.00 10.08 ? 1092 THR D HG23 1 
ATOM   2352 N N    . ILE E 1 15 ? -14.459 13.228 0.782   1.00 10.42 ? 1093 ILE D N    1 
ATOM   2353 C CA   . ILE E 1 15 ? -13.106 13.238 1.324   1.00 14.30 ? 1093 ILE D CA   1 
ATOM   2354 C C    . ILE E 1 15 ? -12.072 13.811 0.367   1.00 16.21 ? 1093 ILE D C    1 
ATOM   2355 O O    . ILE E 1 15 ? -10.909 13.993 0.776   1.00 12.67 ? 1093 ILE D O    1 
ATOM   2356 C CB   . ILE E 1 15 ? -12.702 11.828 1.778   1.00 11.03 ? 1093 ILE D CB   1 
ATOM   2357 C CG1  . ILE E 1 15 ? -12.929 10.829 0.661   1.00 14.38 ? 1093 ILE D CG1  1 
ATOM   2358 C CG2  . ILE E 1 15 ? -13.550 11.419 2.973   1.00 13.45 ? 1093 ILE D CG2  1 
ATOM   2359 C CD1  . ILE E 1 15 ? -12.158 9.530  0.915   1.00 19.38 ? 1093 ILE D CD1  1 
ATOM   2360 H H    . ILE E 1 15 ? -14.559 12.714 0.099   1.00 12.65 ? 1093 ILE D H    1 
ATOM   2361 H HA   . ILE E 1 15 ? -13.089 13.818 2.101   1.00 17.31 ? 1093 ILE D HA   1 
ATOM   2362 H HB   . ILE E 1 15 ? -11.762 11.840 2.016   1.00 13.38 ? 1093 ILE D HB   1 
ATOM   2363 H HG12 . ILE E 1 15 ? -13.875 10.619 0.605   1.00 17.40 ? 1093 ILE D HG12 1 
ATOM   2364 H HG13 . ILE E 1 15 ? -12.623 11.209 -0.177  1.00 17.40 ? 1093 ILE D HG13 1 
ATOM   2365 H HG21 . ILE E 1 15 ? -13.252 10.552 3.290   1.00 16.29 ? 1093 ILE D HG21 1 
ATOM   2366 H HG22 . ILE E 1 15 ? -13.448 12.081 3.675   1.00 16.29 ? 1093 ILE D HG22 1 
ATOM   2367 H HG23 . ILE E 1 15 ? -14.479 11.369 2.699   1.00 16.29 ? 1093 ILE D HG23 1 
ATOM   2368 H HD11 . ILE E 1 15 ? -12.349 8.904  0.200   1.00 23.41 ? 1093 ILE D HD11 1 
ATOM   2369 H HD12 . ILE E 1 15 ? -11.208 9.726  0.938   1.00 23.41 ? 1093 ILE D HD12 1 
ATOM   2370 H HD13 . ILE E 1 15 ? -12.439 9.157  1.765   1.00 23.41 ? 1093 ILE D HD13 1 
ATOM   2371 N N    . TYR E 1 16 ? -12.455 14.117 -0.873  1.00 10.62 ? 1094 TYR D N    1 
ATOM   2372 C CA   . TYR E 1 16 ? -11.629 14.852 -1.807  1.00 15.33 ? 1094 TYR D CA   1 
ATOM   2373 C C    . TYR E 1 16 ? -12.487 15.895 -2.503  1.00 15.84 ? 1094 TYR D C    1 
ATOM   2374 O O    . TYR E 1 16 ? -13.723 15.857 -2.455  1.00 11.87 ? 1094 TYR D O    1 
ATOM   2375 C CB   . TYR E 1 16 ? -11.000 13.928 -2.845  1.00 17.05 ? 1094 TYR D CB   1 
ATOM   2376 C CG   . TYR E 1 16 ? -10.131 12.877 -2.233  1.00 13.17 ? 1094 TYR D CG   1 
ATOM   2377 C CD1  . TYR E 1 16 ? -8.953  13.213 -1.609  1.00 15.95 ? 1094 TYR D CD1  1 
ATOM   2378 C CD2  . TYR E 1 16 ? -10.489 11.546 -2.277  1.00 20.65 ? 1094 TYR D CD2  1 
ATOM   2379 C CE1  . TYR E 1 16 ? -8.150  12.255 -1.040  1.00 15.56 ? 1094 TYR D CE1  1 
ATOM   2380 C CE2  . TYR E 1 16 ? -9.690  10.581 -1.727  1.00 23.43 ? 1094 TYR D CE2  1 
ATOM   2381 C CZ   . TYR E 1 16 ? -8.520  10.947 -1.123  1.00 19.81 ? 1094 TYR D CZ   1 
ATOM   2382 O OH   . TYR E 1 16 ? -7.759  9.967  -0.561  1.00 24.33 ? 1094 TYR D OH   1 
ATOM   2383 H H    . TYR E 1 16 ? -13.219 13.899 -1.201  1.00 12.89 ? 1094 TYR D H    1 
ATOM   2384 H HA   . TYR E 1 16 ? -10.918 15.303 -1.325  1.00 18.55 ? 1094 TYR D HA   1 
ATOM   2385 H HB2  . TYR E 1 16 ? -11.706 13.483 -3.341  1.00 20.61 ? 1094 TYR D HB2  1 
ATOM   2386 H HB3  . TYR E 1 16 ? -10.454 14.456 -3.449  1.00 20.61 ? 1094 TYR D HB3  1 
ATOM   2387 H HD1  . TYR E 1 16 ? -8.696  14.106 -1.572  1.00 19.29 ? 1094 TYR D HD1  1 
ATOM   2388 H HD2  . TYR E 1 16 ? -11.287 11.300 -2.687  1.00 24.92 ? 1094 TYR D HD2  1 
ATOM   2389 H HE1  . TYR E 1 16 ? -7.364  12.497 -0.605  1.00 18.82 ? 1094 TYR D HE1  1 
ATOM   2390 H HE2  . TYR E 1 16 ? -9.940  9.686  -1.764  1.00 28.26 ? 1094 TYR D HE2  1 
ATOM   2391 H HH   . TYR E 1 16 ? -7.128  10.309 -0.124  1.00 29.34 ? 1094 TYR D HH   1 
ATOM   2392 N N    . ASP E 1 17 ? -11.810 16.872 -3.085  1.00 10.07 ? 1095 ASP D N    1 
ATOM   2393 C CA   . ASP E 1 17 ? -12.434 17.764 -4.054  1.00 13.93 ? 1095 ASP D CA   1 
ATOM   2394 C C    . ASP E 1 17 ? -12.741 17.024 -5.347  1.00 11.35 ? 1095 ASP D C    1 
ATOM   2395 O O    . ASP E 1 17 ? -12.076 16.055 -5.693  1.00 12.16 ? 1095 ASP D O    1 
ATOM   2396 C CB   . ASP E 1 17 ? -11.518 18.936 -4.366  1.00 12.63 ? 1095 ASP D CB   1 
ATOM   2397 C CG   . ASP E 1 17 ? -11.327 19.852 -3.207  1.00 17.15 ? 1095 ASP D CG   1 
ATOM   2398 O OD1  . ASP E 1 17 ? -11.883 19.593 -2.107  1.00 14.37 ? 1095 ASP D OD1  1 
ATOM   2399 O OD2  . ASP E 1 17 ? -10.577 20.845 -3.392  1.00 20.92 ? 1095 ASP D OD2  1 
ATOM   2400 H H    . ASP E 1 17 ? -10.981 17.043 -2.936  1.00 12.23 ? 1095 ASP D H    1 
ATOM   2401 H HA   . ASP E 1 17 ? -13.261 18.103 -3.679  1.00 16.86 ? 1095 ASP D HA   1 
ATOM   2402 H HB2  . ASP E 1 17 ? -10.647 18.596 -4.625  1.00 15.30 ? 1095 ASP D HB2  1 
ATOM   2403 H HB3  . ASP E 1 17 ? -11.902 19.451 -5.093  1.00 15.30 ? 1095 ASP D HB3  1 
ATOM   2404 N N    . CYS E 1 18 ? -13.734 17.519 -6.093  1.00 12.84 ? 1096 CYS D N    1 
ATOM   2405 C CA   . CYS E 1 18 ? -14.129 16.897 -7.356  1.00 12.53 ? 1096 CYS D CA   1 
ATOM   2406 C C    . CYS E 1 18 ? -14.742 17.950 -8.272  1.00 14.36 ? 1096 CYS D C    1 
ATOM   2407 O O    . CYS E 1 18 ? -15.668 18.659 -7.876  1.00 12.46 ? 1096 CYS D O    1 
ATOM   2408 C CB   . CYS E 1 18 ? -15.108 15.745 -7.119  1.00 14.06 ? 1096 CYS D CB   1 
ATOM   2409 S SG   . CYS E 1 18 ? -15.503 14.758 -8.573  1.00 14.06 ? 1096 CYS D SG   1 
ATOM   2410 H H    . CYS E 1 18 ? -14.194 18.216 -5.887  1.00 15.55 ? 1096 CYS D H    1 
ATOM   2411 H HA   . CYS E 1 18 ? -13.337 16.548 -7.796  1.00 15.19 ? 1096 CYS D HA   1 
ATOM   2412 H HB2  . CYS E 1 18 ? -14.723 15.148 -6.459  1.00 17.02 ? 1096 CYS D HB2  1 
ATOM   2413 H HB3  . CYS E 1 18 ? -15.940 16.115 -6.786  1.00 17.02 ? 1096 CYS D HB3  1 
ATOM   2414 H HG   . CYS E 1 18 ? -16.013 15.464 -9.398  1.00 17.02 ? 1096 CYS D HG   1 
ATOM   2415 N N    . GLN E 1 19 ? -14.181 18.084 -9.471  1.00 14.66 ? 1097 GLN D N    1 
ATOM   2416 C CA   . GLN E 1 19 ? -14.721 18.937 -10.525 1.00 14.09 ? 1097 GLN D CA   1 
ATOM   2417 C C    . GLN E 1 19 ? -15.387 18.037 -11.550 1.00 13.36 ? 1097 GLN D C    1 
ATOM   2418 O O    . GLN E 1 19 ? -14.792 17.053 -12.002 1.00 10.70 ? 1097 GLN D O    1 
ATOM   2419 C CB   . GLN E 1 19 ? -13.606 19.785 -11.153 1.00 18.67 ? 1097 GLN D CB   1 
ATOM   2420 C CG   . GLN E 1 19 ? -13.985 20.761 -12.283 1.00 28.86 ? 1097 GLN D CG   1 
ATOM   2421 C CD   . GLN E 1 19 ? -15.405 21.346 -12.248 1.00 45.56 ? 1097 GLN D CD   1 
ATOM   2422 O OE1  . GLN E 1 19 ? -16.259 21.009 -13.089 1.00 34.88 ? 1097 GLN D OE1  1 
ATOM   2423 N NE2  . GLN E 1 19 ? -15.642 22.271 -11.315 1.00 50.83 ? 1097 GLN D NE2  1 
ATOM   2424 H H    . GLN E 1 19 ? -13.462 17.676 -9.706  1.00 17.74 ? 1097 GLN D H    1 
ATOM   2425 H HA   . GLN E 1 19 ? -15.385 19.555 -10.180 1.00 17.05 ? 1097 GLN D HA   1 
ATOM   2426 H HB2  . GLN E 1 19 ? -13.208 20.318 -10.447 1.00 22.54 ? 1097 GLN D HB2  1 
ATOM   2427 H HB3  . GLN E 1 19 ? -12.945 19.177 -11.521 1.00 22.54 ? 1097 GLN D HB3  1 
ATOM   2428 H HG2  . GLN E 1 19 ? -13.370 21.510 -12.252 1.00 34.78 ? 1097 GLN D HG2  1 
ATOM   2429 H HG3  . GLN E 1 19 ? -13.894 20.292 -13.128 1.00 34.78 ? 1097 GLN D HG3  1 
ATOM   2430 H HE21 . GLN E 1 19 ? -15.015 22.507 -10.776 1.00 61.14 ? 1097 GLN D HE21 1 
ATOM   2431 H HE22 . GLN E 1 19 ? -16.421 22.630 -11.253 1.00 61.14 ? 1097 GLN D HE22 1 
ATOM   2432 N N    . ALA E 1 20 ? -16.638 18.344 -11.868 1.00 11.88 ? 1098 ALA D N    1 
ATOM   2433 C CA   . ALA E 1 20 ? -17.368 17.556 -12.846 1.00 12.67 ? 1098 ALA D CA   1 
ATOM   2434 C C    . ALA E 1 20 ? -16.615 17.551 -14.165 1.00 9.48  ? 1098 ALA D C    1 
ATOM   2435 O O    . ALA E 1 20 ? -16.098 18.575 -14.591 1.00 8.83  ? 1098 ALA D O    1 
ATOM   2436 C CB   . ALA E 1 20 ? -18.773 18.144 -13.042 1.00 15.88 ? 1098 ALA D CB   1 
ATOM   2437 H H    . ALA E 1 20 ? -17.083 19.000 -11.534 1.00 14.40 ? 1098 ALA D H    1 
ATOM   2438 H HA   . ALA E 1 20 ? -17.462 16.641 -12.537 1.00 15.35 ? 1098 ALA D HA   1 
ATOM   2439 H HB1  . ALA E 1 20 ? -19.222 17.659 -13.753 1.00 19.20 ? 1098 ALA D HB1  1 
ATOM   2440 H HB2  . ALA E 1 20 ? -19.272 18.054 -12.215 1.00 19.20 ? 1098 ALA D HB2  1 
ATOM   2441 H HB3  . ALA E 1 20 ? -18.693 19.081 -13.281 1.00 19.20 ? 1098 ALA D HB3  1 
ATOM   2442 N N    . ASP E 1 21 ? -16.552 16.386 -14.799 1.00 7.37  ? 1099 ASP D N    1 
ATOM   2443 C CA   . ASP E 1 21 ? -16.019 16.251 -16.140 1.00 10.82 ? 1099 ASP D CA   1 
ATOM   2444 C C    . ASP E 1 21 ? -17.119 16.231 -17.190 1.00 16.88 ? 1099 ASP D C    1 
ATOM   2445 O O    . ASP E 1 21 ? -16.868 16.582 -18.343 1.00 12.72 ? 1099 ASP D O    1 
ATOM   2446 C CB   . ASP E 1 21 ? -15.199 14.966 -16.243 1.00 12.05 ? 1099 ASP D CB   1 
ATOM   2447 C CG   . ASP E 1 21 ? -14.074 14.921 -15.227 1.00 16.31 ? 1099 ASP D CG   1 
ATOM   2448 O OD1  . ASP E 1 21 ? -13.286 15.897 -15.156 1.00 17.09 ? 1099 ASP D OD1  1 
ATOM   2449 O OD2  . ASP E 1 21 ? -14.008 13.913 -14.497 1.00 19.89 ? 1099 ASP D OD2  1 
ATOM   2450 H H    . ASP E 1 21 ? -16.820 15.642 -14.462 1.00 9.00  ? 1099 ASP D H    1 
ATOM   2451 H HA   . ASP E 1 21 ? -15.426 16.993 -16.336 1.00 13.13 ? 1099 ASP D HA   1 
ATOM   2452 H HB2  . ASP E 1 21 ? -15.780 14.205 -16.086 1.00 14.60 ? 1099 ASP D HB2  1 
ATOM   2453 H HB3  . ASP E 1 21 ? -14.809 14.908 -17.129 1.00 14.60 ? 1099 ASP D HB3  1 
ATOM   2454 N N    . ASN E 1 22 ? -18.335 15.917 -16.779 1.00 13.52 ? 1100 ASN D N    1 
ATOM   2455 C CA   . ASN E 1 22 ? -19.478 15.786 -17.657 1.00 15.77 ? 1100 ASN D CA   1 
ATOM   2456 C C    . ASN E 1 22 ? -20.618 16.529 -16.992 1.00 12.75 ? 1100 ASN D C    1 
ATOM   2457 O O    . ASN E 1 22 ? -20.573 16.821 -15.807 1.00 6.42  ? 1100 ASN D O    1 
ATOM   2458 C CB   . ASN E 1 22 ? -19.817 14.319 -17.890 1.00 17.05 ? 1100 ASN D CB   1 
ATOM   2459 C CG   . ASN E 1 22 ? -18.685 13.569 -18.572 1.00 20.43 ? 1100 ASN D CG   1 
ATOM   2460 O OD1  . ASN E 1 22 ? -18.478 13.708 -19.776 1.00 20.72 ? 1100 ASN D OD1  1 
ATOM   2461 N ND2  . ASN E 1 22 ? -17.955 12.762 -17.803 1.00 14.15 ? 1100 ASN D ND2  1 
ATOM   2462 H H    . ASN E 1 22 ? -18.531 15.768 -15.955 1.00 16.37 ? 1100 ASN D H    1 
ATOM   2463 H HA   . ASN E 1 22 ? -19.319 16.174 -18.532 1.00 19.07 ? 1100 ASN D HA   1 
ATOM   2464 H HB2  . ASN E 1 22 ? -19.992 13.894 -17.037 1.00 20.61 ? 1100 ASN D HB2  1 
ATOM   2465 H HB3  . ASN E 1 22 ? -20.603 14.261 -18.457 1.00 20.61 ? 1100 ASN D HB3  1 
ATOM   2466 H HD21 . ASN E 1 22 ? -17.304 12.316 -18.144 1.00 17.12 ? 1100 ASN D HD21 1 
ATOM   2467 H HD22 . ASN E 1 22 ? -18.135 12.687 -16.965 1.00 17.12 ? 1100 ASN D HD22 1 
ATOM   2468 N N    . ASP E 1 23 ? -21.601 16.893 -17.798 1.00 10.97 ? 1101 ASP D N    1 
ATOM   2469 C CA   . ASP E 1 23 ? -22.652 17.796 -17.384 1.00 11.54 ? 1101 ASP D CA   1 
ATOM   2470 C C    . ASP E 1 23 ? -23.677 17.113 -16.494 1.00 8.30  ? 1101 ASP D C    1 
ATOM   2471 O O    . ASP E 1 23 ? -24.566 17.786 -15.986 1.00 12.09 ? 1101 ASP D O    1 
ATOM   2472 C CB   . ASP E 1 23 ? -23.325 18.395 -18.641 1.00 11.63 ? 1101 ASP D CB   1 
ATOM   2473 C CG   . ASP E 1 23 ? -22.730 19.760 -19.060 1.00 10.13 ? 1101 ASP D CG   1 
ATOM   2474 O OD1  . ASP E 1 23 ? -22.124 20.448 -18.212 1.00 10.54 ? 1101 ASP D OD1  1 
ATOM   2475 O OD2  . ASP E 1 23 ? -22.909 20.183 -20.244 1.00 9.72  ? 1101 ASP D OD2  1 
ATOM   2476 H H    . ASP E 1 23 ? -21.682 16.622 -18.610 1.00 13.31 ? 1101 ASP D H    1 
ATOM   2477 H HA   . ASP E 1 23 ? -22.280 18.533 -16.875 1.00 13.99 ? 1101 ASP D HA   1 
ATOM   2478 H HB2  . ASP E 1 23 ? -23.209 17.780 -19.382 1.00 14.11 ? 1101 ASP D HB2  1 
ATOM   2479 H HB3  . ASP E 1 23 ? -24.269 18.524 -18.461 1.00 14.11 ? 1101 ASP D HB3  1 
ATOM   2480 N N    . ASP E 1 24 ? -23.548 15.821 -16.219 1.00 9.64  ? 1102 ASP D N    1 
ATOM   2481 C CA   . ASP E 1 24 ? -24.410 15.198 -15.228 1.00 9.01  ? 1102 ASP D CA   1 
ATOM   2482 C C    . ASP E 1 24 ? -23.691 14.906 -13.918 1.00 7.35  ? 1102 ASP D C    1 
ATOM   2483 O O    . ASP E 1 24 ? -24.269 14.270 -13.048 1.00 10.12 ? 1102 ASP D O    1 
ATOM   2484 C CB   . ASP E 1 24 ? -25.038 13.916 -15.764 1.00 5.97  ? 1102 ASP D CB   1 
ATOM   2485 C CG   . ASP E 1 24 ? -24.039 12.881 -16.220 1.00 12.57 ? 1102 ASP D CG   1 
ATOM   2486 O OD1  . ASP E 1 24 ? -22.854 13.211 -16.487 1.00 9.84  ? 1102 ASP D OD1  1 
ATOM   2487 O OD2  . ASP E 1 24 ? -24.470 11.708 -16.360 1.00 14.08 ? 1102 ASP D OD2  1 
ATOM   2488 H H    . ASP E 1 24 ? -22.977 15.295 -16.588 1.00 11.72 ? 1102 ASP D H    1 
ATOM   2489 H HA   . ASP E 1 24 ? -25.132 15.820 -15.045 1.00 10.96 ? 1102 ASP D HA   1 
ATOM   2490 H HB2  . ASP E 1 24 ? -25.575 13.517 -15.062 1.00 7.31  ? 1102 ASP D HB2  1 
ATOM   2491 H HB3  . ASP E 1 24 ? -25.598 14.139 -16.524 1.00 7.31  ? 1102 ASP D HB3  1 
ATOM   2492 N N    . GLU E 1 25 ? -22.470 15.385 -13.758 1.00 9.27  ? 1103 GLU D N    1 
ATOM   2493 C CA   . GLU E 1 25 ? -21.616 15.079 -12.617 1.00 6.53  ? 1103 GLU D CA   1 
ATOM   2494 C C    . GLU E 1 25 ? -21.656 16.204 -11.600 1.00 5.75  ? 1103 GLU D C    1 
ATOM   2495 O O    . GLU E 1 25 ? -21.734 17.383 -11.957 1.00 12.26 ? 1103 GLU D O    1 
ATOM   2496 C CB   . GLU E 1 25 ? -20.164 14.837 -13.064 1.00 7.89  ? 1103 GLU D CB   1 
ATOM   2497 C CG   . GLU E 1 25 ? -19.965 13.494 -13.738 1.00 7.34  ? 1103 GLU D CG   1 
ATOM   2498 C CD   . GLU E 1 25 ? -18.555 13.320 -14.329 1.00 16.11 ? 1103 GLU D CD   1 
ATOM   2499 O OE1  . GLU E 1 25 ? -17.673 14.177 -14.018 1.00 15.07 ? 1103 GLU D OE1  1 
ATOM   2500 O OE2  . GLU E 1 25 ? -18.362 12.333 -15.101 1.00 12.25 ? 1103 GLU D OE2  1 
ATOM   2501 H H    . GLU E 1 25 ? -22.093 15.914 -14.321 1.00 11.27 ? 1103 GLU D H    1 
ATOM   2502 H HA   . GLU E 1 25 ? -21.942 14.272 -12.189 1.00 7.98  ? 1103 GLU D HA   1 
ATOM   2503 H HB2  . GLU E 1 25 ? -19.910 15.529 -13.694 1.00 9.62  ? 1103 GLU D HB2  1 
ATOM   2504 H HB3  . GLU E 1 25 ? -19.586 14.870 -12.285 1.00 9.62  ? 1103 GLU D HB3  1 
ATOM   2505 H HG2  . GLU E 1 25 ? -20.104 12.791 -13.086 1.00 8.96  ? 1103 GLU D HG2  1 
ATOM   2506 H HG3  . GLU E 1 25 ? -20.605 13.408 -14.462 1.00 8.96  ? 1103 GLU D HG3  1 
ATOM   2507 N N    . LEU E 1 26 ? -21.556 15.826 -10.323 1.00 7.07  ? 1104 LEU D N    1 
ATOM   2508 C CA   . LEU E 1 26 ? -21.522 16.770 -9.221  1.00 5.02  ? 1104 LEU D CA   1 
ATOM   2509 C C    . LEU E 1 26 ? -20.095 17.265 -8.994  1.00 7.58  ? 1104 LEU D C    1 
ATOM   2510 O O    . LEU E 1 26 ? -19.139 16.473 -8.969  1.00 9.44  ? 1104 LEU D O    1 
ATOM   2511 C CB   . LEU E 1 26 ? -22.084 16.085 -7.972  1.00 6.61  ? 1104 LEU D CB   1 
ATOM   2512 C CG   . LEU E 1 26 ? -22.221 16.906 -6.696  1.00 7.86  ? 1104 LEU D CG   1 
ATOM   2513 C CD1  . LEU E 1 26 ? -23.165 18.020 -6.757  1.00 11.50 ? 1104 LEU D CD1  1 
ATOM   2514 C CD2  . LEU E 1 26 ? -22.604 15.999 -5.512  1.00 12.42 ? 1104 LEU D CD2  1 
ATOM   2515 H H    . LEU E 1 26 ? -21.506 15.006 -10.070 1.00 8.62  ? 1104 LEU D H    1 
ATOM   2516 H HA   . LEU E 1 26 ? -22.058 17.554 -9.420  1.00 6.16  ? 1104 LEU D HA   1 
ATOM   2517 H HB2  . LEU E 1 26 ? -22.972 15.761 -8.189  1.00 8.08  ? 1104 LEU D HB2  1 
ATOM   2518 H HB3  . LEU E 1 26 ? -21.502 15.339 -7.759  1.00 8.08  ? 1104 LEU D HB3  1 
ATOM   2519 H HG   . LEU E 1 26 ? -21.348 17.310 -6.568  1.00 9.58  ? 1104 LEU D HG   1 
ATOM   2520 H HD11 . LEU E 1 26 ? -23.097 18.538 -5.940  1.00 13.95 ? 1104 LEU D HD11 1 
ATOM   2521 H HD12 . LEU E 1 26 ? -22.947 18.578 -7.521  1.00 13.95 ? 1104 LEU D HD12 1 
ATOM   2522 H HD13 . LEU E 1 26 ? -24.064 17.667 -6.851  1.00 13.95 ? 1104 LEU D HD13 1 
ATOM   2523 H HD21 . LEU E 1 26 ? -22.704 16.545 -4.716  1.00 15.05 ? 1104 LEU D HD21 1 
ATOM   2524 H HD22 . LEU E 1 26 ? -23.440 15.552 -5.715  1.00 15.05 ? 1104 LEU D HD22 1 
ATOM   2525 H HD23 . LEU E 1 26 ? -21.902 15.343 -5.377  1.00 15.05 ? 1104 LEU D HD23 1 
ATOM   2526 N N    . THR E 1 27 ? -19.973 18.578 -8.821  1.00 6.58  ? 1105 THR D N    1 
ATOM   2527 C CA   . THR E 1 27 ? -18.762 19.280 -8.429  1.00 13.32 ? 1105 THR D CA   1 
ATOM   2528 C C    . THR E 1 27 ? -18.854 19.553 -6.939  1.00 11.04 ? 1105 THR D C    1 
ATOM   2529 O O    . THR E 1 27 ? -19.905 19.962 -6.444  1.00 10.76 ? 1105 THR D O    1 
ATOM   2530 C CB   . THR E 1 27 ? -18.617 20.599 -9.194  1.00 15.81 ? 1105 THR D CB   1 
ATOM   2531 O OG1  . THR E 1 27 ? -18.319 20.301 -10.549 1.00 18.38 ? 1105 THR D OG1  1 
ATOM   2532 C CG2  . THR E 1 27 ? -17.522 21.455 -8.650  1.00 12.00 ? 1105 THR D CG2  1 
ATOM   2533 H H    . THR E 1 27 ? -20.629 19.122 -8.935  1.00 8.04  ? 1105 THR D H    1 
ATOM   2534 H HA   . THR E 1 27 ? -17.979 18.741 -8.620  1.00 16.13 ? 1105 THR D HA   1 
ATOM   2535 H HB   . THR E 1 27 ? -19.444 21.099 -9.112  1.00 19.12 ? 1105 THR D HB   1 
ATOM   2536 H HG1  . THR E 1 27 ? -18.279 21.011 -10.997 1.00 22.20 ? 1105 THR D HG1  1 
ATOM   2537 H HG21 . THR E 1 27 ? -17.329 22.178 -9.267  1.00 14.55 ? 1105 THR D HG21 1 
ATOM   2538 H HG22 . THR E 1 27 ? -17.788 21.832 -7.797  1.00 14.55 ? 1105 THR D HG22 1 
ATOM   2539 H HG23 . THR E 1 27 ? -16.719 20.926 -8.524  1.00 14.55 ? 1105 THR D HG23 1 
ATOM   2540 N N    . PHE E 1 28 ? -17.787 19.262 -6.218  1.00 7.71  ? 1106 PHE D N    1 
ATOM   2541 C CA   . PHE E 1 28 ? -17.825 19.477 -4.782  1.00 8.01  ? 1106 PHE D CA   1 
ATOM   2542 C C    . PHE E 1 28 ? -16.408 19.664 -4.260  1.00 10.19 ? 1106 PHE D C    1 
ATOM   2543 O O    . PHE E 1 28 ? -15.435 19.372 -4.947  1.00 8.06  ? 1106 PHE D O    1 
ATOM   2544 C CB   . PHE E 1 28 ? -18.535 18.331 -4.065  1.00 7.04  ? 1106 PHE D CB   1 
ATOM   2545 C CG   . PHE E 1 28 ? -18.023 16.965 -4.369  1.00 5.14  ? 1106 PHE D CG   1 
ATOM   2546 C CD1  . PHE E 1 28 ? -17.003 16.417 -3.633  1.00 7.68  ? 1106 PHE D CD1  1 
ATOM   2547 C CD2  . PHE E 1 28 ? -18.632 16.183 -5.310  1.00 5.70  ? 1106 PHE D CD2  1 
ATOM   2548 C CE1  . PHE E 1 28 ? -16.588 15.120 -3.866  1.00 6.90  ? 1106 PHE D CE1  1 
ATOM   2549 C CE2  . PHE E 1 28 ? -18.196 14.925 -5.584  1.00 7.18  ? 1106 PHE D CE2  1 
ATOM   2550 C CZ   . PHE E 1 28 ? -17.178 14.374 -4.845  1.00 9.60  ? 1106 PHE D CZ   1 
ATOM   2551 H H    . PHE E 1 28 ? -17.048 18.948 -6.527  1.00 9.40  ? 1106 PHE D H    1 
ATOM   2552 H HA   . PHE E 1 28 ? -18.312 20.297 -4.605  1.00 9.76  ? 1106 PHE D HA   1 
ATOM   2553 H HB2  . PHE E 1 28 ? -18.444 18.466 -3.109  1.00 8.60  ? 1106 PHE D HB2  1 
ATOM   2554 H HB3  . PHE E 1 28 ? -19.473 18.349 -4.315  1.00 8.60  ? 1106 PHE D HB3  1 
ATOM   2555 H HD1  . PHE E 1 28 ? -16.588 16.922 -2.972  1.00 9.36  ? 1106 PHE D HD1  1 
ATOM   2556 H HD2  . PHE E 1 28 ? -19.363 16.520 -5.775  1.00 6.99  ? 1106 PHE D HD2  1 
ATOM   2557 H HE1  . PHE E 1 28 ? -15.904 14.754 -3.354  1.00 8.42  ? 1106 PHE D HE1  1 
ATOM   2558 H HE2  . PHE E 1 28 ? -18.588 14.437 -6.272  1.00 8.76  ? 1106 PHE D HE2  1 
ATOM   2559 H HZ   . PHE E 1 28 ? -16.895 13.503 -5.009  1.00 11.66 ? 1106 PHE D HZ   1 
ATOM   2560 N N    . ILE E 1 29 ? -16.313 20.181 -3.034  1.00 14.34 ? 1107 ILE D N    1 
ATOM   2561 C CA   . ILE E 1 29 ? -15.066 20.200 -2.290  1.00 11.81 ? 1107 ILE D CA   1 
ATOM   2562 C C    . ILE E 1 29 ? -15.156 19.153 -1.193  1.00 12.05 ? 1107 ILE D C    1 
ATOM   2563 O O    . ILE E 1 29 ? -16.216 18.587 -0.908  1.00 7.24  ? 1107 ILE D O    1 
ATOM   2564 C CB   . ILE E 1 29 ? -14.737 21.589 -1.704  1.00 10.12 ? 1107 ILE D CB   1 
ATOM   2565 C CG1  . ILE E 1 29 ? -15.839 22.061 -0.746  1.00 15.29 ? 1107 ILE D CG1  1 
ATOM   2566 C CG2  . ILE E 1 29 ? -14.529 22.593 -2.825  1.00 16.33 ? 1107 ILE D CG2  1 
ATOM   2567 C CD1  . ILE E 1 29 ? -15.463 23.243 0.117   1.00 12.35 ? 1107 ILE D CD1  1 
ATOM   2568 H H    . ILE E 1 29 ? -16.973 20.532 -2.608  1.00 17.36 ? 1107 ILE D H    1 
ATOM   2569 H HA   . ILE E 1 29 ? -14.344 19.966 -2.893  1.00 14.31 ? 1107 ILE D HA   1 
ATOM   2570 H HB   . ILE E 1 29 ? -13.916 21.515 -1.194  1.00 12.29 ? 1107 ILE D HB   1 
ATOM   2571 H HG12 . ILE E 1 29 ? -16.614 22.317 -1.270  1.00 18.49 ? 1107 ILE D HG12 1 
ATOM   2572 H HG13 . ILE E 1 29 ? -16.066 21.328 -0.153  1.00 18.49 ? 1107 ILE D HG13 1 
ATOM   2573 H HG21 . ILE E 1 29 ? -14.260 23.442 -2.442  1.00 19.74 ? 1107 ILE D HG21 1 
ATOM   2574 H HG22 . ILE E 1 29 ? -13.836 22.264 -3.419  1.00 19.74 ? 1107 ILE D HG22 1 
ATOM   2575 H HG23 . ILE E 1 29 ? -15.361 22.698 -3.313  1.00 19.74 ? 1107 ILE D HG23 1 
ATOM   2576 H HD11 . ILE E 1 29 ? -16.204 23.452 0.706   1.00 14.97 ? 1107 ILE D HD11 1 
ATOM   2577 H HD12 . ILE E 1 29 ? -14.678 23.016 0.640   1.00 14.97 ? 1107 ILE D HD12 1 
ATOM   2578 H HD13 . ILE E 1 29 ? -15.270 24.003 -0.455  1.00 14.97 ? 1107 ILE D HD13 1 
ATOM   2579 N N    . GLU E 1 30 ? -14.001 18.876 -0.598  1.00 11.04 ? 1108 GLU D N    1 
ATOM   2580 C CA   . GLU E 1 30 ? -13.893 17.995 0.546   1.00 7.18  ? 1108 GLU D CA   1 
ATOM   2581 C C    . GLU E 1 30 ? -14.723 18.532 1.705   1.00 7.03  ? 1108 GLU D C    1 
ATOM   2582 O O    . GLU E 1 30 ? -14.861 19.741 1.891   1.00 8.15  ? 1108 GLU D O    1 
ATOM   2583 C CB   . GLU E 1 30 ? -12.418 17.874 0.956   1.00 9.37  ? 1108 GLU D CB   1 
ATOM   2584 C CG   . GLU E 1 30 ? -12.190 16.838 1.972   1.00 10.91 ? 1108 GLU D CG   1 
ATOM   2585 C CD   . GLU E 1 30 ? -12.285 17.369 3.376   1.00 11.47 ? 1108 GLU D CD   1 
ATOM   2586 O OE1  . GLU E 1 30 ? -12.553 18.570 3.562   1.00 12.52 ? 1108 GLU D OE1  1 
ATOM   2587 O OE2  . GLU E 1 30 ? -12.019 16.586 4.312   1.00 14.30 ? 1108 GLU D OE2  1 
ATOM   2588 H H    . GLU E 1 30 ? -13.244 19.198 -0.848  1.00 13.40 ? 1108 GLU D H    1 
ATOM   2589 H HA   . GLU E 1 30 ? -14.226 17.111 0.325   1.00 8.76  ? 1108 GLU D HA   1 
ATOM   2590 H HB2  . GLU E 1 30 ? -11.891 17.648 0.174   1.00 11.40 ? 1108 GLU D HB2  1 
ATOM   2591 H HB3  . GLU E 1 30 ? -12.122 18.722 1.322   1.00 11.40 ? 1108 GLU D HB3  1 
ATOM   2592 H HG2  . GLU E 1 30 ? -12.858 16.142 1.868   1.00 13.24 ? 1108 GLU D HG2  1 
ATOM   2593 H HG3  . GLU E 1 30 ? -11.302 16.467 1.851   1.00 13.24 ? 1108 GLU D HG3  1 
ATOM   2594 N N    . GLY E 1 31 ? -15.216 17.621 2.538   1.00 6.73  ? 1109 GLY D N    1 
ATOM   2595 C CA   . GLY E 1 31 ? -15.951 18.019 3.709   1.00 11.70 ? 1109 GLY D CA   1 
ATOM   2596 C C    . GLY E 1 31 ? -17.445 18.213 3.538   1.00 14.51 ? 1109 GLY D C    1 
ATOM   2597 O O    . GLY E 1 31 ? -18.109 18.633 4.490   1.00 18.15 ? 1109 GLY D O    1 
ATOM   2598 H H    . GLY E 1 31 ? -15.133 16.770 2.439   1.00 8.23  ? 1109 GLY D H    1 
ATOM   2599 H HA2  . GLY E 1 31 ? -15.824 17.342 4.392   1.00 14.19 ? 1109 GLY D HA2  1 
ATOM   2600 H HA3  . GLY E 1 31 ? -15.586 18.860 4.025   1.00 14.19 ? 1109 GLY D HA3  1 
ATOM   2601 N N    . GLU E 1 32 ? -17.996 17.945 2.374   1.00 11.64 ? 1110 GLU D N    1 
ATOM   2602 C CA   . GLU E 1 32 ? -19.412 18.207 2.148   1.00 9.97  ? 1110 GLU D CA   1 
ATOM   2603 C C    . GLU E 1 32 ? -20.199 16.941 2.341   1.00 5.57  ? 1110 GLU D C    1 
ATOM   2604 O O    . GLU E 1 32 ? -19.708 15.856 2.050   1.00 7.64  ? 1110 GLU D O    1 
ATOM   2605 C CB   . GLU E 1 32 ? -19.651 18.756 0.738   1.00 8.23  ? 1110 GLU D CB   1 
ATOM   2606 C CG   . GLU E 1 32 ? -18.959 20.107 0.490   1.00 9.13  ? 1110 GLU D CG   1 
ATOM   2607 C CD   . GLU E 1 32 ? -19.505 20.833 -0.756  1.00 13.43 ? 1110 GLU D CD   1 
ATOM   2608 O OE1  . GLU E 1 32 ? -20.545 21.514 -0.652  1.00 20.74 ? 1110 GLU D OE1  1 
ATOM   2609 O OE2  . GLU E 1 32 ? -18.909 20.718 -1.849  1.00 10.70 ? 1110 GLU D OE2  1 
ATOM   2610 H H    . GLU E 1 32 ? -17.579 17.613 1.700   1.00 14.12 ? 1110 GLU D H    1 
ATOM   2611 H HA   . GLU E 1 32 ? -19.726 18.870 2.782   1.00 12.12 ? 1110 GLU D HA   1 
ATOM   2612 H HB2  . GLU E 1 32 ? -19.306 18.121 0.091   1.00 10.02 ? 1110 GLU D HB2  1 
ATOM   2613 H HB3  . GLU E 1 32 ? -20.604 18.880 0.606   1.00 10.02 ? 1110 GLU D HB3  1 
ATOM   2614 H HG2  . GLU E 1 32 ? -19.102 20.681 1.259   1.00 11.10 ? 1110 GLU D HG2  1 
ATOM   2615 H HG3  . GLU E 1 32 ? -18.010 19.957 0.359   1.00 11.10 ? 1110 GLU D HG3  1 
ATOM   2616 N N    . VAL E 1 33 ? -21.442 17.095 2.814   1.00 14.98 ? 1111 VAL D N    1 
ATOM   2617 C CA   . VAL E 1 33 ? -22.380 15.987 2.951   1.00 11.17 ? 1111 VAL D CA   1 
ATOM   2618 C C    . VAL E 1 33 ? -23.211 15.896 1.680   1.00 4.84  ? 1111 VAL D C    1 
ATOM   2619 O O    . VAL E 1 33 ? -23.710 16.907 1.182   1.00 8.51  ? 1111 VAL D O    1 
ATOM   2620 C CB   . VAL E 1 33 ? -23.265 16.167 4.198   1.00 17.62 ? 1111 VAL D CB   1 
ATOM   2621 C CG1  . VAL E 1 33 ? -24.344 15.101 4.243   1.00 11.10 ? 1111 VAL D CG1  1 
ATOM   2622 C CG2  . VAL E 1 33 ? -22.408 16.093 5.463   1.00 16.91 ? 1111 VAL D CG2  1 
ATOM   2623 H H    . VAL E 1 33 ? -21.767 17.850 3.066   1.00 18.12 ? 1111 VAL D H    1 
ATOM   2624 H HA   . VAL E 1 33 ? -21.890 15.156 3.051   1.00 13.55 ? 1111 VAL D HA   1 
ATOM   2625 H HB   . VAL E 1 33 ? -23.693 17.036 4.157   1.00 21.30 ? 1111 VAL D HB   1 
ATOM   2626 H HG11 . VAL E 1 33 ? -24.776 15.125 5.112   1.00 13.47 ? 1111 VAL D HG11 1 
ATOM   2627 H HG12 . VAL E 1 33 ? -24.994 15.279 3.546   1.00 13.47 ? 1111 VAL D HG12 1 
ATOM   2628 H HG13 . VAL E 1 33 ? -23.936 14.232 4.101   1.00 13.47 ? 1111 VAL D HG13 1 
ATOM   2629 H HG21 . VAL E 1 33 ? -22.979 16.213 6.238   1.00 20.44 ? 1111 VAL D HG21 1 
ATOM   2630 H HG22 . VAL E 1 33 ? -21.977 15.225 5.502   1.00 20.44 ? 1111 VAL D HG22 1 
ATOM   2631 H HG23 . VAL E 1 33 ? -21.739 16.794 5.433   1.00 20.44 ? 1111 VAL D HG23 1 
ATOM   2632 N N    . ILE E 1 34 ? -23.304 14.687 1.127   1.00 4.97  ? 1112 ILE D N    1 
ATOM   2633 C CA   . ILE E 1 34 ? -24.131 14.380 -0.026  1.00 8.97  ? 1112 ILE D CA   1 
ATOM   2634 C C    . ILE E 1 34 ? -25.264 13.488 0.441   1.00 6.40  ? 1112 ILE D C    1 
ATOM   2635 O O    . ILE E 1 34 ? -25.038 12.538 1.198   1.00 9.81  ? 1112 ILE D O    1 
ATOM   2636 C CB   . ILE E 1 34 ? -23.338 13.688 -1.153  1.00 12.05 ? 1112 ILE D CB   1 
ATOM   2637 C CG1  . ILE E 1 34 ? -22.301 14.659 -1.736  1.00 8.78  ? 1112 ILE D CG1  1 
ATOM   2638 C CG2  . ILE E 1 34 ? -24.268 13.184 -2.284  1.00 6.19  ? 1112 ILE D CG2  1 
ATOM   2639 C CD1  . ILE E 1 34 ? -21.298 13.996 -2.655  1.00 11.88 ? 1112 ILE D CD1  1 
ATOM   2640 H H    . ILE E 1 34 ? -22.875 14.001 1.420   1.00 6.11  ? 1112 ILE D H    1 
ATOM   2641 H HA   . ILE E 1 34 ? -24.493 15.208 -0.379  1.00 10.91 ? 1112 ILE D HA   1 
ATOM   2642 H HB   . ILE E 1 34 ? -22.892 12.920 -0.764  1.00 14.61 ? 1112 ILE D HB   1 
ATOM   2643 H HG12 . ILE E 1 34 ? -22.764 15.342 -2.245  1.00 10.69 ? 1112 ILE D HG12 1 
ATOM   2644 H HG13 . ILE E 1 34 ? -21.809 15.066 -1.005  1.00 10.69 ? 1112 ILE D HG13 1 
ATOM   2645 H HG21 . ILE E 1 34 ? -23.724 12.834 -3.007  1.00 7.57  ? 1112 ILE D HG21 1 
ATOM   2646 H HG22 . ILE E 1 34 ? -24.842 12.486 -1.934  1.00 7.57  ? 1112 ILE D HG22 1 
ATOM   2647 H HG23 . ILE E 1 34 ? -24.806 13.926 -2.604  1.00 7.57  ? 1112 ILE D HG23 1 
ATOM   2648 H HD11 . ILE E 1 34 ? -20.571 14.615 -2.828  1.00 14.41 ? 1112 ILE D HD11 1 
ATOM   2649 H HD12 . ILE E 1 34 ? -20.957 13.196 -2.226  1.00 14.41 ? 1112 ILE D HD12 1 
ATOM   2650 H HD13 . ILE E 1 34 ? -21.739 13.763 -3.487  1.00 14.41 ? 1112 ILE D HD13 1 
ATOM   2651 N N    . ILE E 1 35 ? -26.474 13.803 0.002   1.00 6.43  ? 1113 ILE D N    1 
ATOM   2652 C CA   . ILE E 1 35 ? -27.620 12.905 0.093   1.00 5.64  ? 1113 ILE D CA   1 
ATOM   2653 C C    . ILE E 1 35 ? -27.654 12.012 -1.139  1.00 7.39  ? 1113 ILE D C    1 
ATOM   2654 O O    . ILE E 1 35 ? -27.930 12.473 -2.255  1.00 7.99  ? 1113 ILE D O    1 
ATOM   2655 C CB   . ILE E 1 35 ? -28.935 13.692 0.225   1.00 7.59  ? 1113 ILE D CB   1 
ATOM   2656 C CG1  . ILE E 1 35 ? -28.851 14.682 1.366   1.00 9.00  ? 1113 ILE D CG1  1 
ATOM   2657 C CG2  . ILE E 1 35 ? -30.151 12.733 0.357   1.00 6.33  ? 1113 ILE D CG2  1 
ATOM   2658 C CD1  . ILE E 1 35 ? -28.591 14.009 2.678   1.00 15.08 ? 1113 ILE D CD1  1 
ATOM   2659 H H    . ILE E 1 35 ? -26.665 14.556 -0.367  1.00 7.86  ? 1113 ILE D H    1 
ATOM   2660 H HA   . ILE E 1 35 ? -27.511 12.341 0.875   1.00 6.91  ? 1113 ILE D HA   1 
ATOM   2661 H HB   . ILE E 1 35 ? -29.069 14.204 -0.588  1.00 9.26  ? 1113 ILE D HB   1 
ATOM   2662 H HG12 . ILE E 1 35 ? -28.127 15.304 1.196   1.00 10.94 ? 1113 ILE D HG12 1 
ATOM   2663 H HG13 . ILE E 1 35 ? -29.692 15.162 1.433   1.00 10.94 ? 1113 ILE D HG13 1 
ATOM   2664 H HG21 . ILE E 1 35 ? -30.939 13.251 0.585   1.00 7.75  ? 1113 ILE D HG21 1 
ATOM   2665 H HG22 . ILE E 1 35 ? -30.288 12.278 -0.489  1.00 7.75  ? 1113 ILE D HG22 1 
ATOM   2666 H HG23 . ILE E 1 35 ? -29.968 12.085 1.055   1.00 7.75  ? 1113 ILE D HG23 1 
ATOM   2667 H HD11 . ILE E 1 35 ? -28.653 14.667 3.388   1.00 18.24 ? 1113 ILE D HD11 1 
ATOM   2668 H HD12 . ILE E 1 35 ? -29.254 13.314 2.813   1.00 18.24 ? 1113 ILE D HD12 1 
ATOM   2669 H HD13 . ILE E 1 35 ? -27.702 13.621 2.663   1.00 18.24 ? 1113 ILE D HD13 1 
ATOM   2670 N N    . VAL E 1 36 ? -27.500 10.719 -0.923  1.00 7.85  ? 1114 VAL D N    1 
ATOM   2671 C CA   . VAL E 1 36 ? -27.471 9.746  -2.000  1.00 7.81  ? 1114 VAL D CA   1 
ATOM   2672 C C    . VAL E 1 36 ? -28.903 9.391  -2.360  1.00 12.38 ? 1114 VAL D C    1 
ATOM   2673 O O    . VAL E 1 36 ? -29.681 8.970  -1.502  1.00 11.66 ? 1114 VAL D O    1 
ATOM   2674 C CB   . VAL E 1 36 ? -26.684 8.494  -1.594  1.00 9.54  ? 1114 VAL D CB   1 
ATOM   2675 C CG1  . VAL E 1 36 ? -26.630 7.511  -2.754  1.00 8.93  ? 1114 VAL D CG1  1 
ATOM   2676 C CG2  . VAL E 1 36 ? -25.302 8.885  -1.114  1.00 14.57 ? 1114 VAL D CG2  1 
ATOM   2677 H H    . VAL E 1 36 ? -27.408 10.371 -0.142  1.00 9.57  ? 1114 VAL D H    1 
ATOM   2678 H HA   . VAL E 1 36 ? -27.041 10.138 -2.777  1.00 9.52  ? 1114 VAL D HA   1 
ATOM   2679 H HB   . VAL E 1 36 ? -27.129 8.046  -0.857  1.00 11.60 ? 1114 VAL D HB   1 
ATOM   2680 H HG11 . VAL E 1 36 ? -26.038 6.779  -2.521  1.00 10.86 ? 1114 VAL D HG11 1 
ATOM   2681 H HG12 . VAL E 1 36 ? -27.524 7.173  -2.923  1.00 10.86 ? 1114 VAL D HG12 1 
ATOM   2682 H HG13 . VAL E 1 36 ? -26.296 7.969  -3.541  1.00 10.86 ? 1114 VAL D HG13 1 
ATOM   2683 H HG21 . VAL E 1 36 ? -24.781 8.081  -0.962  1.00 17.63 ? 1114 VAL D HG21 1 
ATOM   2684 H HG22 . VAL E 1 36 ? -24.875 9.433  -1.792  1.00 17.63 ? 1114 VAL D HG22 1 
ATOM   2685 H HG23 . VAL E 1 36 ? -25.384 9.387  -0.288  1.00 17.63 ? 1114 VAL D HG23 1 
ATOM   2686 N N    . THR E 1 37 ? -29.264 9.595  -3.624  1.00 13.41 ? 1115 THR D N    1 
ATOM   2687 C CA   . THR E 1 37 ? -30.617 9.321  -4.102  1.00 14.83 ? 1115 THR D CA   1 
ATOM   2688 C C    . THR E 1 37 ? -30.653 8.294  -5.228  1.00 16.11 ? 1115 THR D C    1 
ATOM   2689 O O    . THR E 1 37 ? -31.738 7.978  -5.729  1.00 20.23 ? 1115 THR D O    1 
ATOM   2690 C CB   . THR E 1 37 ? -31.281 10.615 -4.574  1.00 11.14 ? 1115 THR D CB   1 
ATOM   2691 O OG1  . THR E 1 37 ? -30.490 11.214 -5.607  1.00 10.05 ? 1115 THR D OG1  1 
ATOM   2692 C CG2  . THR E 1 37 ? -31.367 11.615 -3.460  1.00 13.88 ? 1115 THR D CG2  1 
ATOM   2693 H H    . THR E 1 37 ? -28.737 9.897  -4.233  1.00 16.24 ? 1115 THR D H    1 
ATOM   2694 H HA   . THR E 1 37 ? -31.141 8.969  -3.366  1.00 17.94 ? 1115 THR D HA   1 
ATOM   2695 H HB   . THR E 1 37 ? -32.172 10.401 -4.891  1.00 13.51 ? 1115 THR D HB   1 
ATOM   2696 H HG1  . THR E 1 37 ? -30.464 10.709 -6.278  1.00 12.21 ? 1115 THR D HG1  1 
ATOM   2697 H HG21 . THR E 1 37 ? -31.853 12.400 -3.756  1.00 16.80 ? 1115 THR D HG21 1 
ATOM   2698 H HG22 . THR E 1 37 ? -31.829 11.227 -2.700  1.00 16.80 ? 1115 THR D HG22 1 
ATOM   2699 H HG23 . THR E 1 37 ? -30.476 11.882 -3.184  1.00 16.80 ? 1115 THR D HG23 1 
ATOM   2700 N N    . GLY E 1 38 ? -29.514 7.764  -5.635  1.00 15.81 ? 1116 GLY D N    1 
ATOM   2701 C CA   . GLY E 1 38 ? -29.487 6.838  -6.741  1.00 13.33 ? 1116 GLY D CA   1 
ATOM   2702 C C    . GLY E 1 38 ? -28.095 6.283  -6.945  1.00 17.40 ? 1116 GLY D C    1 
ATOM   2703 O O    . GLY E 1 38 ? -27.112 6.726  -6.335  1.00 12.28 ? 1116 GLY D O    1 
ATOM   2704 H H    . GLY E 1 38 ? -28.745 7.927  -5.285  1.00 19.12 ? 1116 GLY D H    1 
ATOM   2705 H HA2  . GLY E 1 38 ? -30.093 6.102  -6.567  1.00 16.15 ? 1116 GLY D HA2  1 
ATOM   2706 H HA3  . GLY E 1 38 ? -29.764 7.290  -7.554  1.00 16.15 ? 1116 GLY D HA3  1 
ATOM   2707 N N    . GLU E 1 39 ? -28.024 5.326  -7.847  1.00 19.00 ? 1117 GLU D N    1 
ATOM   2708 C CA   . GLU E 1 39 ? -26.790 4.668  -8.196  1.00 17.80 ? 1117 GLU D CA   1 
ATOM   2709 C C    . GLU E 1 39 ? -26.683 4.596  -9.701  1.00 14.84 ? 1117 GLU D C    1 
ATOM   2710 O O    . GLU E 1 39 ? -27.655 4.266  -10.380 1.00 21.04 ? 1117 GLU D O    1 
ATOM   2711 C CB   . GLU E 1 39 ? -26.736 3.256  -7.647  1.00 27.50 ? 1117 GLU D CB   1 
ATOM   2712 C CG   . GLU E 1 39 ? -26.533 3.103  -6.183  1.00 38.69 ? 1117 GLU D CG   1 
ATOM   2713 C CD   . GLU E 1 39 ? -26.071 1.699  -5.863  1.00 46.45 ? 1117 GLU D CD   1 
ATOM   2714 O OE1  . GLU E 1 39 ? -25.611 0.968  -6.772  1.00 45.37 ? 1117 GLU D OE1  1 
ATOM   2715 O OE2  . GLU E 1 39 ? -26.226 1.300  -4.698  1.00 55.30 ? 1117 GLU D OE2  1 
ATOM   2716 H H    . GLU E 1 39 ? -28.703 5.031  -8.285  1.00 22.95 ? 1117 GLU D H    1 
ATOM   2717 H HA   . GLU E 1 39 ? -26.045 5.174  -7.837  1.00 21.50 ? 1117 GLU D HA   1 
ATOM   2718 H HB2  . GLU E 1 39 ? -27.576 2.820  -7.861  1.00 33.14 ? 1117 GLU D HB2  1 
ATOM   2719 H HB3  . GLU E 1 39 ? -26.002 2.794  -8.082  1.00 33.14 ? 1117 GLU D HB3  1 
ATOM   2720 H HG2  . GLU E 1 39 ? -25.856 3.729  -5.881  1.00 46.58 ? 1117 GLU D HG2  1 
ATOM   2721 H HG3  . GLU E 1 39 ? -27.368 3.269  -5.719  1.00 46.58 ? 1117 GLU D HG3  1 
ATOM   2722 N N    . GLU E 1 40 ? -25.508 4.920  -10.217 1.00 15.35 ? 1118 GLU D N    1 
ATOM   2723 C CA   . GLU E 1 40 ? -25.195 4.585  -11.594 1.00 14.07 ? 1118 GLU D CA   1 
ATOM   2724 C C    . GLU E 1 40 ? -24.571 3.196  -11.681 1.00 21.63 ? 1118 GLU D C    1 
ATOM   2725 O O    . GLU E 1 40 ? -24.992 2.357  -12.476 1.00 20.11 ? 1118 GLU D O    1 
ATOM   2726 C CB   . GLU E 1 40 ? -24.246 5.609  -12.196 1.00 18.12 ? 1118 GLU D CB   1 
ATOM   2727 C CG   . GLU E 1 40 ? -23.717 5.174  -13.547 1.00 22.10 ? 1118 GLU D CG   1 
ATOM   2728 C CD   . GLU E 1 40 ? -23.110 6.313  -14.277 1.00 22.12 ? 1118 GLU D CD   1 
ATOM   2729 O OE1  . GLU E 1 40 ? -23.877 7.171  -14.774 1.00 25.72 ? 1118 GLU D OE1  1 
ATOM   2730 O OE2  . GLU E 1 40 ? -21.864 6.379  -14.321 1.00 21.12 ? 1118 GLU D OE2  1 
ATOM   2731 H H    . GLU E 1 40 ? -24.882 5.330  -9.793  1.00 18.57 ? 1118 GLU D H    1 
ATOM   2732 H HA   . GLU E 1 40 ? -26.014 4.604  -12.114 1.00 17.03 ? 1118 GLU D HA   1 
ATOM   2733 H HB2  . GLU E 1 40 ? -24.717 6.449  -12.312 1.00 21.88 ? 1118 GLU D HB2  1 
ATOM   2734 H HB3  . GLU E 1 40 ? -23.491 5.731  -11.600 1.00 21.88 ? 1118 GLU D HB3  1 
ATOM   2735 H HG2  . GLU E 1 40 ? -23.038 4.492  -13.423 1.00 26.67 ? 1118 GLU D HG2  1 
ATOM   2736 H HG3  . GLU E 1 40 ? -24.446 4.821  -14.081 1.00 26.67 ? 1118 GLU D HG3  1 
ATOM   2737 N N    . ASP E 1 41 ? -23.552 2.941  -10.880 1.00 22.34 ? 1119 ASP D N    1 
ATOM   2738 C CA   . ASP E 1 41 ? -22.966 1.615  -10.756 1.00 23.14 ? 1119 ASP D CA   1 
ATOM   2739 C C    . ASP E 1 41 ? -22.194 1.575  -9.448  1.00 22.44 ? 1119 ASP D C    1 
ATOM   2740 O O    . ASP E 1 41 ? -22.337 2.458  -8.595  1.00 20.22 ? 1119 ASP D O    1 
ATOM   2741 C CB   . ASP E 1 41 ? -22.059 1.258  -11.938 1.00 17.10 ? 1119 ASP D CB   1 
ATOM   2742 C CG   . ASP E 1 41 ? -20.844 2.164  -12.059 1.00 19.46 ? 1119 ASP D CG   1 
ATOM   2743 O OD1  . ASP E 1 41 ? -20.426 2.826  -11.077 1.00 22.27 ? 1119 ASP D OD1  1 
ATOM   2744 O OD2  . ASP E 1 41 ? -20.276 2.223  -13.167 1.00 26.18 ? 1119 ASP D OD2  1 
ATOM   2745 H H    . ASP E 1 41 ? -23.171 3.532  -10.385 1.00 26.96 ? 1119 ASP D H    1 
ATOM   2746 H HA   . ASP E 1 41 ? -23.695 0.976  -10.737 1.00 27.92 ? 1119 ASP D HA   1 
ATOM   2747 H HB2  . ASP E 1 41 ? -21.742 0.348  -11.826 1.00 20.67 ? 1119 ASP D HB2  1 
ATOM   2748 H HB3  . ASP E 1 41 ? -22.570 1.333  -12.759 1.00 20.67 ? 1119 ASP D HB3  1 
ATOM   2749 N N    . GLN E 1 42 ? -21.372 0.542  -9.287  1.00 20.26 ? 1120 GLN D N    1 
ATOM   2750 C CA   . GLN E 1 42 ? -20.676 0.366  -8.014  1.00 26.07 ? 1120 GLN D CA   1 
ATOM   2751 C C    . GLN E 1 42 ? -19.708 1.502  -7.745  1.00 17.52 ? 1120 GLN D C    1 
ATOM   2752 O O    . GLN E 1 42 ? -19.389 1.766  -6.584  1.00 21.72 ? 1120 GLN D O    1 
ATOM   2753 C CB   . GLN E 1 42 ? -19.933 -0.972 -7.986  1.00 37.07 ? 1120 GLN D CB   1 
ATOM   2754 C CG   . GLN E 1 42 ? -20.756 -2.231 -8.289  1.00 47.23 ? 1120 GLN D CG   1 
ATOM   2755 C CD   . GLN E 1 42 ? -21.905 -2.436 -7.333  1.00 61.00 ? 1120 GLN D CD   1 
ATOM   2756 O OE1  . GLN E 1 42 ? -22.899 -1.708 -7.363  1.00 55.21 ? 1120 GLN D OE1  1 
ATOM   2757 N NE2  . GLN E 1 42 ? -21.763 -3.426 -6.447  1.00 56.76 ? 1120 GLN D NE2  1 
ATOM   2758 H H    . GLN E 1 42 ? -21.203 -0.056 -9.882  1.00 24.46 ? 1120 GLN D H    1 
ATOM   2759 H HA   . GLN E 1 42 ? -21.339 0.353  -7.305  1.00 31.43 ? 1120 GLN D HA   1 
ATOM   2760 H HB2  . GLN E 1 42 ? -19.223 -0.934 -8.646  1.00 44.63 ? 1120 GLN D HB2  1 
ATOM   2761 H HB3  . GLN E 1 42 ? -19.556 -1.087 -7.100  1.00 44.63 ? 1120 GLN D HB3  1 
ATOM   2762 H HG2  . GLN E 1 42 ? -21.122 -2.159 -9.184  1.00 56.82 ? 1120 GLN D HG2  1 
ATOM   2763 H HG3  . GLN E 1 42 ? -20.176 -3.007 -8.229  1.00 56.82 ? 1120 GLN D HG3  1 
ATOM   2764 H HE21 . GLN E 1 42 ? -21.046 -3.902 -6.445  1.00 68.25 ? 1120 GLN D HE21 1 
ATOM   2765 H HE22 . GLN E 1 42 ? -22.387 -3.587 -5.878  1.00 68.25 ? 1120 GLN D HE22 1 
ATOM   2766 N N    . GLU E 1 43 ? -19.224 2.169  -8.796  1.00 18.16 ? 1121 GLU D N    1 
ATOM   2767 C CA   . GLU E 1 43 ? -18.249 3.232  -8.641  1.00 15.85 ? 1121 GLU D CA   1 
ATOM   2768 C C    . GLU E 1 43 ? -18.845 4.631  -8.731  1.00 10.37 ? 1121 GLU D C    1 
ATOM   2769 O O    . GLU E 1 43 ? -18.148 5.600  -8.429  1.00 15.76 ? 1121 GLU D O    1 
ATOM   2770 C CB   . GLU E 1 43 ? -17.147 3.081  -9.698  1.00 20.11 ? 1121 GLU D CB   1 
ATOM   2771 C CG   . GLU E 1 43 ? -16.439 1.731  -9.562  1.00 29.39 ? 1121 GLU D CG   1 
ATOM   2772 C CD   . GLU E 1 43 ? -14.984 1.767  -9.970  1.00 49.62 ? 1121 GLU D CD   1 
ATOM   2773 O OE1  . GLU E 1 43 ? -14.714 2.103  -11.146 1.00 52.22 ? 1121 GLU D OE1  1 
ATOM   2774 O OE2  . GLU E 1 43 ? -14.119 1.484  -9.105  1.00 50.87 ? 1121 GLU D OE2  1 
ATOM   2775 H H    . GLU E 1 43 ? -19.452 2.018  -9.612  1.00 21.94 ? 1121 GLU D H    1 
ATOM   2776 H HA   . GLU E 1 43 ? -17.845 3.151  -7.763  1.00 19.17 ? 1121 GLU D HA   1 
ATOM   2777 H HB2  . GLU E 1 43 ? -17.539 3.136  -10.583 1.00 24.28 ? 1121 GLU D HB2  1 
ATOM   2778 H HB3  . GLU E 1 43 ? -16.490 3.786  -9.581  1.00 24.28 ? 1121 GLU D HB3  1 
ATOM   2779 H HG2  . GLU E 1 43 ? -16.481 1.448  -8.635  1.00 35.42 ? 1121 GLU D HG2  1 
ATOM   2780 H HG3  . GLU E 1 43 ? -16.890 1.084  -10.127 1.00 35.42 ? 1121 GLU D HG3  1 
ATOM   2781 N N    . TRP E 1 44 ? -20.087 4.780  -9.163  1.00 14.42 ? 1122 TRP D N    1 
ATOM   2782 C CA   . TRP E 1 44 ? -20.677 6.096  -9.344  1.00 11.21 ? 1122 TRP D CA   1 
ATOM   2783 C C    . TRP E 1 44 ? -22.065 6.083  -8.718  1.00 14.44 ? 1122 TRP D C    1 
ATOM   2784 O O    . TRP E 1 44 ? -22.894 5.244  -9.065  1.00 10.24 ? 1122 TRP D O    1 
ATOM   2785 C CB   . TRP E 1 44 ? -20.730 6.443  -10.827 1.00 15.79 ? 1122 TRP D CB   1 
ATOM   2786 C CG   . TRP E 1 44 ? -19.364 6.705  -11.435 1.00 9.35  ? 1122 TRP D CG   1 
ATOM   2787 C CD1  . TRP E 1 44 ? -18.522 5.786  -12.016 1.00 12.95 ? 1122 TRP D CD1  1 
ATOM   2788 C CD2  . TRP E 1 44 ? -18.690 7.953  -11.496 1.00 7.77  ? 1122 TRP D CD2  1 
ATOM   2789 N NE1  . TRP E 1 44 ? -17.382 6.402  -12.460 1.00 13.86 ? 1122 TRP D NE1  1 
ATOM   2790 C CE2  . TRP E 1 44 ? -17.452 7.731  -12.140 1.00 12.22 ? 1122 TRP D CE2  1 
ATOM   2791 C CE3  . TRP E 1 44 ? -19.004 9.241  -11.072 1.00 9.80  ? 1122 TRP D CE3  1 
ATOM   2792 C CZ2  . TRP E 1 44 ? -16.555 8.740  -12.367 1.00 12.08 ? 1122 TRP D CZ2  1 
ATOM   2793 C CZ3  . TRP E 1 44 ? -18.115 10.253 -11.328 1.00 10.87 ? 1122 TRP D CZ3  1 
ATOM   2794 C CH2  . TRP E 1 44 ? -16.896 9.994  -11.950 1.00 12.71 ? 1122 TRP D CH2  1 
ATOM   2795 H H    . TRP E 1 44 ? -20.613 4.129  -9.359  1.00 17.45 ? 1122 TRP D H    1 
ATOM   2796 H HA   . TRP E 1 44 ? -20.156 6.778  -8.891  1.00 13.60 ? 1122 TRP D HA   1 
ATOM   2797 H HB2  . TRP E 1 44 ? -21.132 5.702  -11.307 1.00 19.10 ? 1122 TRP D HB2  1 
ATOM   2798 H HB3  . TRP E 1 44 ? -21.266 7.243  -10.943 1.00 19.10 ? 1122 TRP D HB3  1 
ATOM   2799 H HD1  . TRP E 1 44 ? -18.701 4.877  -12.095 1.00 15.68 ? 1122 TRP D HD1  1 
ATOM   2800 H HE1  . TRP E 1 44 ? -16.731 6.018  -12.871 1.00 16.78 ? 1122 TRP D HE1  1 
ATOM   2801 H HE3  . TRP E 1 44 ? -19.802 9.412  -10.624 1.00 11.90 ? 1122 TRP D HE3  1 
ATOM   2802 H HZ2  . TRP E 1 44 ? -15.743 8.576  -12.790 1.00 14.64 ? 1122 TRP D HZ2  1 
ATOM   2803 H HZ3  . TRP E 1 44 ? -18.329 11.124 -11.083 1.00 13.18 ? 1122 TRP D HZ3  1 
ATOM   2804 H HH2  . TRP E 1 44 ? -16.299 10.694 -12.084 1.00 15.40 ? 1122 TRP D HH2  1 
ATOM   2805 N N    . TRP E 1 45 ? -22.309 6.984  -7.779  1.00 8.96  ? 1123 TRP D N    1 
ATOM   2806 C CA   . TRP E 1 45 ? -23.637 7.149  -7.222  1.00 11.52 ? 1123 TRP D CA   1 
ATOM   2807 C C    . TRP E 1 45 ? -24.184 8.495  -7.664  1.00 11.09 ? 1123 TRP D C    1 
ATOM   2808 O O    . TRP E 1 45 ? -23.510 9.270  -8.346  1.00 8.82  ? 1123 TRP D O    1 
ATOM   2809 C CB   . TRP E 1 45 ? -23.614 7.052  -5.704  1.00 9.46  ? 1123 TRP D CB   1 
ATOM   2810 C CG   . TRP E 1 45 ? -23.397 5.687  -5.253  1.00 12.06 ? 1123 TRP D CG   1 
ATOM   2811 C CD1  . TRP E 1 45 ? -23.380 4.553  -6.012  1.00 11.79 ? 1123 TRP D CD1  1 
ATOM   2812 C CD2  . TRP E 1 45 ? -23.118 5.281  -3.911  1.00 14.76 ? 1123 TRP D CD2  1 
ATOM   2813 N NE1  . TRP E 1 45 ? -23.106 3.459  -5.212  1.00 15.25 ? 1123 TRP D NE1  1 
ATOM   2814 C CE2  . TRP E 1 45 ? -22.957 3.884  -3.919  1.00 13.99 ? 1123 TRP D CE2  1 
ATOM   2815 C CE3  . TRP E 1 45 ? -22.995 5.969  -2.705  1.00 15.39 ? 1123 TRP D CE3  1 
ATOM   2816 C CZ2  . TRP E 1 45 ? -22.654 3.169  -2.767  1.00 22.61 ? 1123 TRP D CZ2  1 
ATOM   2817 C CZ3  . TRP E 1 45 ? -22.692 5.252  -1.563  1.00 25.12 ? 1123 TRP D CZ3  1 
ATOM   2818 C CH2  . TRP E 1 45 ? -22.529 3.873  -1.604  1.00 16.40 ? 1123 TRP D CH2  1 
ATOM   2819 H H    . TRP E 1 45 ? -21.717 7.512  -7.447  1.00 10.90 ? 1123 TRP D H    1 
ATOM   2820 H HA   . TRP E 1 45 ? -24.221 6.444  -7.545  1.00 13.97 ? 1123 TRP D HA   1 
ATOM   2821 H HB2  . TRP E 1 45 ? -22.895 7.604  -5.359  1.00 11.49 ? 1123 TRP D HB2  1 
ATOM   2822 H HB3  . TRP E 1 45 ? -24.465 7.357  -5.351  1.00 11.49 ? 1123 TRP D HB3  1 
ATOM   2823 H HD1  . TRP E 1 45 ? -23.530 4.521  -6.930  1.00 14.29 ? 1123 TRP D HD1  1 
ATOM   2824 H HE1  . TRP E 1 45 ? -23.040 2.645  -5.483  1.00 18.45 ? 1123 TRP D HE1  1 
ATOM   2825 H HE3  . TRP E 1 45 ? -23.113 6.891  -2.669  1.00 18.62 ? 1123 TRP D HE3  1 
ATOM   2826 H HZ2  . TRP E 1 45 ? -22.542 2.246  -2.788  1.00 27.28 ? 1123 TRP D HZ2  1 
ATOM   2827 H HZ3  . TRP E 1 45 ? -22.597 5.700  -0.754  1.00 30.29 ? 1123 TRP D HZ3  1 
ATOM   2828 H HH2  . TRP E 1 45 ? -22.329 3.417  -0.819  1.00 19.83 ? 1123 TRP D HH2  1 
ATOM   2829 N N    . ILE E 1 46 ? -25.435 8.752  -7.307  1.00 9.37  ? 1124 ILE D N    1 
ATOM   2830 C CA   . ILE E 1 46 ? -26.121 9.984  -7.672  1.00 9.30  ? 1124 ILE D CA   1 
ATOM   2831 C C    . ILE E 1 46 ? -26.676 10.615 -6.409  1.00 6.97  ? 1124 ILE D C    1 
ATOM   2832 O O    . ILE E 1 46 ? -27.231 9.911  -5.558  1.00 6.47  ? 1124 ILE D O    1 
ATOM   2833 C CB   . ILE E 1 46 ? -27.271 9.730  -8.675  1.00 8.21  ? 1124 ILE D CB   1 
ATOM   2834 C CG1  . ILE E 1 46 ? -26.850 8.713  -9.722  1.00 12.72 ? 1124 ILE D CG1  1 
ATOM   2835 C CG2  . ILE E 1 46 ? -27.706 11.043 -9.292  1.00 9.52  ? 1124 ILE D CG2  1 
ATOM   2836 C CD1  . ILE E 1 46 ? -27.964 8.440  -10.736 1.00 15.71 ? 1124 ILE D CD1  1 
ATOM   2837 H H    . ILE E 1 46 ? -25.919 8.214  -6.842  1.00 11.39 ? 1124 ILE D H    1 
ATOM   2838 H HA   . ILE E 1 46 ? -25.481 10.589 -8.079  1.00 11.31 ? 1124 ILE D HA   1 
ATOM   2839 H HB   . ILE E 1 46 ? -28.031 9.353  -8.205  1.00 10.00 ? 1124 ILE D HB   1 
ATOM   2840 H HG12 . ILE E 1 46 ? -26.079 9.051  -10.203 1.00 15.41 ? 1124 ILE D HG12 1 
ATOM   2841 H HG13 . ILE E 1 46 ? -26.628 7.877  -9.284  1.00 15.41 ? 1124 ILE D HG13 1 
ATOM   2842 H HG21 . ILE E 1 46 ? -28.513 10.896 -9.809  1.00 11.57 ? 1124 ILE D HG21 1 
ATOM   2843 H HG22 . ILE E 1 46 ? -27.879 11.683 -8.583  1.00 11.57 ? 1124 ILE D HG22 1 
ATOM   2844 H HG23 . ILE E 1 46 ? -26.999 11.371 -9.868  1.00 11.57 ? 1124 ILE D HG23 1 
ATOM   2845 H HD11 . ILE E 1 46 ? -27.734 7.651  -11.252 1.00 19.00 ? 1124 ILE D HD11 1 
ATOM   2846 H HD12 . ILE E 1 46 ? -28.796 8.292  -10.259 1.00 19.00 ? 1124 ILE D HD12 1 
ATOM   2847 H HD13 . ILE E 1 46 ? -28.051 9.206  -11.324 1.00 19.00 ? 1124 ILE D HD13 1 
ATOM   2848 N N    . GLY E 1 47 ? -26.587 11.935 -6.313  1.00 5.03  ? 1125 GLY D N    1 
ATOM   2849 C CA   . GLY E 1 47 ? -27.111 12.582 -5.137  1.00 2.89  ? 1125 GLY D CA   1 
ATOM   2850 C C    . GLY E 1 47 ? -27.023 14.079 -5.256  1.00 5.21  ? 1125 GLY D C    1 
ATOM   2851 O O    . GLY E 1 47 ? -26.777 14.632 -6.333  1.00 7.90  ? 1125 GLY D O    1 
ATOM   2852 H H    . GLY E 1 47 ? -26.238 12.456 -6.901  1.00 6.18  ? 1125 GLY D H    1 
ATOM   2853 H HA2  . GLY E 1 47 ? -28.041 12.335 -5.016  1.00 3.61  ? 1125 GLY D HA2  1 
ATOM   2854 H HA3  . GLY E 1 47 ? -26.605 12.302 -4.359  1.00 3.61  ? 1125 GLY D HA3  1 
ATOM   2855 N N    . HIS E 1 48 ? -27.199 14.734 -4.118  1.00 4.34  ? 1126 HIS D N    1 
ATOM   2856 C CA   . HIS E 1 48 ? -27.140 16.177 -4.067  1.00 4.81  ? 1126 HIS D CA   1 
ATOM   2857 C C    . HIS E 1 48 ? -26.577 16.628 -2.751  1.00 5.97  ? 1126 HIS D C    1 
ATOM   2858 O O    . HIS E 1 48 ? -26.526 15.871 -1.788  1.00 9.10  ? 1126 HIS D O    1 
ATOM   2859 C CB   . HIS E 1 48 ? -28.494 16.825 -4.220  1.00 10.23 ? 1126 HIS D CB   1 
ATOM   2860 C CG   . HIS E 1 48 ? -29.510 16.383 -3.208  1.00 6.35  ? 1126 HIS D CG   1 
ATOM   2861 N ND1  . HIS E 1 48 ? -30.288 15.264 -3.387  1.00 7.52  ? 1126 HIS D ND1  1 
ATOM   2862 C CD2  . HIS E 1 48 ? -29.881 16.917 -2.016  1.00 7.69  ? 1126 HIS D CD2  1 
ATOM   2863 C CE1  . HIS E 1 48 ? -31.120 15.145 -2.365  1.00 9.00  ? 1126 HIS D CE1  1 
ATOM   2864 N NE2  . HIS E 1 48 ? -30.896 16.141 -1.526  1.00 9.33  ? 1126 HIS D NE2  1 
ATOM   2865 H H    . HIS E 1 48 ? -27.355 14.359 -3.360  1.00 5.35  ? 1126 HIS D H    1 
ATOM   2866 H HA   . HIS E 1 48 ? -26.557 16.454 -4.791  1.00 5.92  ? 1126 HIS D HA   1 
ATOM   2867 H HB2  . HIS E 1 48 ? -28.389 17.786 -4.131  1.00 12.43 ? 1126 HIS D HB2  1 
ATOM   2868 H HB3  . HIS E 1 48 ? -28.842 16.610 -5.100  1.00 12.43 ? 1126 HIS D HB3  1 
ATOM   2869 H HD2  . HIS E 1 48 ? -29.513 17.669 -1.609  1.00 9.37  ? 1126 HIS D HD2  1 
ATOM   2870 H HE1  . HIS E 1 48 ? -31.754 14.474 -2.256  1.00 10.94 ? 1126 HIS D HE1  1 
ATOM   2871 H HE2  . HIS E 1 48 ? -31.321 16.279 -0.791  1.00 11.34 ? 1126 HIS D HE2  1 
ATOM   2872 N N    . ILE E 1 49 ? -26.152 17.886 -2.721  1.00 10.64 ? 1127 ILE D N    1 
ATOM   2873 C CA   . ILE E 1 49 ? -25.532 18.419 -1.519  1.00 10.48 ? 1127 ILE D CA   1 
ATOM   2874 C C    . ILE E 1 49 ? -26.601 18.639 -0.454  1.00 12.06 ? 1127 ILE D C    1 
ATOM   2875 O O    . ILE E 1 49 ? -27.638 19.261 -0.708  1.00 9.26  ? 1127 ILE D O    1 
ATOM   2876 C CB   . ILE E 1 49 ? -24.771 19.713 -1.831  1.00 10.56 ? 1127 ILE D CB   1 
ATOM   2877 C CG1  . ILE E 1 49 ? -23.638 19.417 -2.832  1.00 12.09 ? 1127 ILE D CG1  1 
ATOM   2878 C CG2  . ILE E 1 49 ? -24.165 20.330 -0.549  1.00 11.22 ? 1127 ILE D CG2  1 
ATOM   2879 C CD1  . ILE E 1 49 ? -22.371 18.765 -2.171  1.00 17.35 ? 1127 ILE D CD1  1 
ATOM   2880 H H    . ILE E 1 49 ? -26.211 18.442 -3.374  1.00 12.92 ? 1127 ILE D H    1 
ATOM   2881 H HA   . ILE E 1 49 ? -24.894 17.773 -1.178  1.00 12.72 ? 1127 ILE D HA   1 
ATOM   2882 H HB   . ILE E 1 49 ? -25.401 20.345 -2.212  1.00 12.81 ? 1127 ILE D HB   1 
ATOM   2883 H HG12 . ILE E 1 49 ? -23.969 18.805 -3.507  1.00 14.65 ? 1127 ILE D HG12 1 
ATOM   2884 H HG13 . ILE E 1 49 ? -23.361 20.249 -3.246  1.00 14.65 ? 1127 ILE D HG13 1 
ATOM   2885 H HG21 . ILE E 1 49 ? -23.475 20.965 -0.799  1.00 13.61 ? 1127 ILE D HG21 1 
ATOM   2886 H HG22 . ILE E 1 49 ? -24.866 20.782 -0.053  1.00 13.61 ? 1127 ILE D HG22 1 
ATOM   2887 H HG23 . ILE E 1 49 ? -23.782 19.622 -0.008  1.00 13.61 ? 1127 ILE D HG23 1 
ATOM   2888 H HD11 . ILE E 1 49 ? -21.835 18.344 -2.861  1.00 20.97 ? 1127 ILE D HD11 1 
ATOM   2889 H HD12 . ILE E 1 49 ? -21.855 19.456 -1.727  1.00 20.97 ? 1127 ILE D HD12 1 
ATOM   2890 H HD13 . ILE E 1 49 ? -22.658 18.101 -1.525  1.00 20.97 ? 1127 ILE D HD13 1 
ATOM   2891 N N    . GLU E 1 50 ? -26.353 18.114 0.745   1.00 8.19  ? 1128 GLU D N    1 
ATOM   2892 C CA   . GLU E 1 50 ? -27.216 18.371 1.871   1.00 9.43  ? 1128 GLU D CA   1 
ATOM   2893 C C    . GLU E 1 50 ? -27.162 19.842 2.217   1.00 14.25 ? 1128 GLU D C    1 
ATOM   2894 O O    . GLU E 1 50 ? -26.084 20.406 2.432   1.00 11.47 ? 1128 GLU D O    1 
ATOM   2895 C CB   . GLU E 1 50 ? -26.789 17.541 3.067   1.00 12.11 ? 1128 GLU D CB   1 
ATOM   2896 C CG   . GLU E 1 50 ? -27.691 17.732 4.242   1.00 14.61 ? 1128 GLU D CG   1 
ATOM   2897 C CD   . GLU E 1 50 ? -27.099 17.042 5.445   1.00 16.74 ? 1128 GLU D CD   1 
ATOM   2898 O OE1  . GLU E 1 50 ? -26.080 17.538 5.989   1.00 15.58 ? 1128 GLU D OE1  1 
ATOM   2899 O OE2  . GLU E 1 50 ? -27.632 15.964 5.777   1.00 25.29 ? 1128 GLU D OE2  1 
ATOM   2900 H H    . GLU E 1 50 ? -25.684 17.604 0.924   1.00 9.98  ? 1128 GLU D H    1 
ATOM   2901 H HA   . GLU E 1 50 ? -28.128 18.125 1.648   1.00 11.46 ? 1128 GLU D HA   1 
ATOM   2902 H HB2  . GLU E 1 50 ? -26.805 16.603 2.823   1.00 14.68 ? 1128 GLU D HB2  1 
ATOM   2903 H HB3  . GLU E 1 50 ? -25.892 17.801 3.329   1.00 14.68 ? 1128 GLU D HB3  1 
ATOM   2904 H HG2  . GLU E 1 50 ? -27.782 18.678 4.437   1.00 17.68 ? 1128 GLU D HG2  1 
ATOM   2905 H HG3  . GLU E 1 50 ? -28.560 17.345 4.056   1.00 17.68 ? 1128 GLU D HG3  1 
ATOM   2906 N N    . GLY E 1 51 ? -28.338 20.464 2.267   1.00 11.42 ? 1129 GLY D N    1 
ATOM   2907 C CA   . GLY E 1 51 ? -28.427 21.887 2.451   1.00 11.72 ? 1129 GLY D CA   1 
ATOM   2908 C C    . GLY E 1 51 ? -28.367 22.695 1.168   1.00 11.98 ? 1129 GLY D C    1 
ATOM   2909 O O    . GLY E 1 51 ? -28.686 23.879 1.205   1.00 12.46 ? 1129 GLY D O    1 
ATOM   2910 H H    . GLY E 1 51 ? -29.099 20.069 2.194   1.00 13.85 ? 1129 GLY D H    1 
ATOM   2911 H HA2  . GLY E 1 51 ? -29.266 22.092 2.892   1.00 14.21 ? 1129 GLY D HA2  1 
ATOM   2912 H HA3  . GLY E 1 51 ? -27.694 22.174 3.017   1.00 14.21 ? 1129 GLY D HA3  1 
ATOM   2913 N N    . GLN E 1 52 ? -27.943 22.106 0.040   1.00 10.09 ? 1130 GLN D N    1 
ATOM   2914 C CA   . GLN E 1 52 ? -27.916 22.809 -1.259  1.00 13.88 ? 1130 GLN D CA   1 
ATOM   2915 C C    . GLN E 1 52 ? -28.393 21.857 -2.351  1.00 10.72 ? 1130 GLN D C    1 
ATOM   2916 O O    . GLN E 1 52 ? -27.621 21.445 -3.232  1.00 10.92 ? 1130 GLN D O    1 
ATOM   2917 C CB   . GLN E 1 52 ? -26.521 23.350 -1.579  1.00 13.61 ? 1130 GLN D CB   1 
ATOM   2918 C CG   . GLN E 1 52 ? -25.948 24.289 -0.532  1.00 14.92 ? 1130 GLN D CG   1 
ATOM   2919 C CD   . GLN E 1 52 ? -24.445 24.502 -0.711  1.00 20.91 ? 1130 GLN D CD   1 
ATOM   2920 O OE1  . GLN E 1 52 ? -23.996 24.945 -1.755  1.00 22.67 ? 1130 GLN D OE1  1 
ATOM   2921 N NE2  . GLN E 1 52 ? -23.673 24.188 0.322   1.00 28.05 ? 1130 GLN D NE2  1 
ATOM   2922 H H    . GLN E 1 52 ? -27.664 21.293 -0.001  1.00 12.26 ? 1130 GLN D H    1 
ATOM   2923 H HA   . GLN E 1 52 ? -28.527 23.560 -1.213  1.00 16.81 ? 1130 GLN D HA   1 
ATOM   2924 H HB2  . GLN E 1 52 ? -25.911 22.600 -1.663  1.00 16.47 ? 1130 GLN D HB2  1 
ATOM   2925 H HB3  . GLN E 1 52 ? -26.564 23.838 -2.416  1.00 16.47 ? 1130 GLN D HB3  1 
ATOM   2926 H HG2  . GLN E 1 52 ? -26.387 25.151 -0.603  1.00 18.05 ? 1130 GLN D HG2  1 
ATOM   2927 H HG3  . GLN E 1 52 ? -26.097 23.912 0.349   1.00 18.05 ? 1130 GLN D HG3  1 
ATOM   2928 H HE21 . GLN E 1 52 ? -24.025 23.881 1.044   1.00 33.81 ? 1130 GLN D HE21 1 
ATOM   2929 H HE22 . GLN E 1 52 ? -22.821 24.291 0.269   1.00 33.81 ? 1130 GLN D HE22 1 
ATOM   2930 N N    . PRO E 1 53 ? -29.684 21.489 -2.324  1.00 11.02 ? 1131 PRO D N    1 
ATOM   2931 C CA   . PRO E 1 53 ? -30.163 20.376 -3.160  1.00 13.27 ? 1131 PRO D CA   1 
ATOM   2932 C C    . PRO E 1 53 ? -30.070 20.637 -4.641  1.00 7.65  ? 1131 PRO D C    1 
ATOM   2933 O O    . PRO E 1 53 ? -30.179 19.694 -5.440  1.00 6.27  ? 1131 PRO D O    1 
ATOM   2934 C CB   . PRO E 1 53 ? -31.629 20.194 -2.732  1.00 12.33 ? 1131 PRO D CB   1 
ATOM   2935 C CG   . PRO E 1 53 ? -31.884 21.157 -1.628  1.00 13.15 ? 1131 PRO D CG   1 
ATOM   2936 C CD   . PRO E 1 53 ? -30.759 22.129 -1.550  1.00 12.40 ? 1131 PRO D CD   1 
ATOM   2937 H HA   . PRO E 1 53 ? -29.661 19.576 -2.938  1.00 16.07 ? 1131 PRO D HA   1 
ATOM   2938 H HB2  . PRO E 1 53 ? -32.210 20.380 -3.486  1.00 14.95 ? 1131 PRO D HB2  1 
ATOM   2939 H HB3  . PRO E 1 53 ? -31.764 19.283 -2.425  1.00 14.95 ? 1131 PRO D HB3  1 
ATOM   2940 H HG2  . PRO E 1 53 ? -32.714 21.627 -1.809  1.00 15.93 ? 1131 PRO D HG2  1 
ATOM   2941 H HG3  . PRO E 1 53 ? -31.956 20.666 -0.795  1.00 15.93 ? 1131 PRO D HG3  1 
ATOM   2942 H HD2  . PRO E 1 53 ? -31.010 22.978 -1.948  1.00 15.03 ? 1131 PRO D HD2  1 
ATOM   2943 H HD3  . PRO E 1 53 ? -30.485 22.263 -0.629  1.00 15.03 ? 1131 PRO D HD3  1 
ATOM   2944 N N    . GLU E 1 54 ? -29.923 21.894 -5.031  1.00 9.34  ? 1132 GLU D N    1 
ATOM   2945 C CA   . GLU E 1 54 ? -29.751 22.191 -6.448  1.00 20.76 ? 1132 GLU D CA   1 
ATOM   2946 C C    . GLU E 1 54 ? -28.356 21.815 -6.934  1.00 15.87 ? 1132 GLU D C    1 
ATOM   2947 O O    . GLU E 1 54 ? -28.134 21.744 -8.142  1.00 10.67 ? 1132 GLU D O    1 
ATOM   2948 C CB   . GLU E 1 54 ? -30.043 23.667 -6.713  1.00 19.98 ? 1132 GLU D CB   1 
ATOM   2949 C CG   . GLU E 1 54 ? -31.425 24.095 -6.144  1.00 26.38 ? 1132 GLU D CG   1 
ATOM   2950 C CD   . GLU E 1 54 ? -32.594 23.403 -6.826  1.00 38.05 ? 1132 GLU D CD   1 
ATOM   2951 O OE1  . GLU E 1 54 ? -32.459 23.118 -8.048  1.00 35.07 ? 1132 GLU D OE1  1 
ATOM   2952 O OE2  . GLU E 1 54 ? -33.626 23.120 -6.154  1.00 33.73 ? 1132 GLU D OE2  1 
ATOM   2953 H H    . GLU E 1 54 ? -29.920 22.579 -4.511  1.00 11.36 ? 1132 GLU D H    1 
ATOM   2954 H HA   . GLU E 1 54 ? -30.390 21.678 -6.968  1.00 25.05 ? 1132 GLU D HA   1 
ATOM   2955 H HB2  . GLU E 1 54 ? -29.359 24.209 -6.289  1.00 24.13 ? 1132 GLU D HB2  1 
ATOM   2956 H HB3  . GLU E 1 54 ? -30.046 23.825 -7.670  1.00 24.13 ? 1132 GLU D HB3  1 
ATOM   2957 H HG2  . GLU E 1 54 ? -31.458 23.875 -5.199  1.00 31.80 ? 1132 GLU D HG2  1 
ATOM   2958 H HG3  . GLU E 1 54 ? -31.533 25.052 -6.265  1.00 31.80 ? 1132 GLU D HG3  1 
ATOM   2959 N N    . ARG E 1 55 ? -27.412 21.589 -6.029  1.00 11.06 ? 1133 ARG D N    1 
ATOM   2960 C CA   . ARG E 1 55 ? -26.112 21.050 -6.417  1.00 5.99  ? 1133 ARG D CA   1 
ATOM   2961 C C    . ARG E 1 55 ? -26.209 19.534 -6.385  1.00 7.24  ? 1133 ARG D C    1 
ATOM   2962 O O    . ARG E 1 55 ? -26.225 18.922 -5.315  1.00 11.08 ? 1133 ARG D O    1 
ATOM   2963 C CB   . ARG E 1 55 ? -25.031 21.568 -5.493  1.00 9.20  ? 1133 ARG D CB   1 
ATOM   2964 C CG   . ARG E 1 55 ? -24.806 23.065 -5.547  1.00 11.33 ? 1133 ARG D CG   1 
ATOM   2965 C CD   . ARG E 1 55 ? -23.776 23.469 -4.482  1.00 15.25 ? 1133 ARG D CD   1 
ATOM   2966 N NE   . ARG E 1 55 ? -22.524 22.730 -4.657  1.00 9.24  ? 1133 ARG D NE   1 
ATOM   2967 C CZ   . ARG E 1 55 ? -21.694 22.401 -3.669  1.00 12.67 ? 1133 ARG D CZ   1 
ATOM   2968 N NH1  . ARG E 1 55 ? -21.885 22.826 -2.438  1.00 8.87  ? 1133 ARG D NH1  1 
ATOM   2969 N NH2  . ARG E 1 55 ? -20.642 21.629 -3.928  1.00 11.60 ? 1133 ARG D NH2  1 
ATOM   2970 H H    . ARG E 1 55 ? -27.499 21.738 -5.187  1.00 13.42 ? 1133 ARG D H    1 
ATOM   2971 H HA   . ARG E 1 55 ? -25.894 21.325 -7.322  1.00 7.33  ? 1133 ARG D HA   1 
ATOM   2972 H HB2  . ARG E 1 55 ? -25.273 21.342 -4.582  1.00 11.18 ? 1133 ARG D HB2  1 
ATOM   2973 H HB3  . ARG E 1 55 ? -24.194 21.139 -5.730  1.00 11.18 ? 1133 ARG D HB3  1 
ATOM   2974 H HG2  . ARG E 1 55 ? -24.467 23.316 -6.421  1.00 13.75 ? 1133 ARG D HG2  1 
ATOM   2975 H HG3  . ARG E 1 55 ? -25.639 23.529 -5.368  1.00 13.75 ? 1133 ARG D HG3  1 
ATOM   2976 H HD2  . ARG E 1 55 ? -23.586 24.417 -4.560  1.00 18.45 ? 1133 ARG D HD2  1 
ATOM   2977 H HD3  . ARG E 1 55 ? -24.129 23.272 -3.600  1.00 18.45 ? 1133 ARG D HD3  1 
ATOM   2978 H HE   . ARG E 1 55 ? -22.310 22.491 -5.454  1.00 11.24 ? 1133 ARG D HE   1 
ATOM   2979 H HH11 . ARG E 1 55 ? -22.559 23.328 -2.256  1.00 10.79 ? 1133 ARG D HH11 1 
ATOM   2980 H HH12 . ARG E 1 55 ? -21.336 22.601 -1.816  1.00 10.79 ? 1133 ARG D HH12 1 
ATOM   2981 H HH21 . ARG E 1 55 ? -20.503 21.347 -4.729  1.00 14.07 ? 1133 ARG D HH21 1 
ATOM   2982 H HH22 . ARG E 1 55 ? -20.101 21.412 -3.296  1.00 14.07 ? 1133 ARG D HH22 1 
ATOM   2983 N N    . LYS E 1 56 ? -26.266 18.918 -7.559  1.00 5.17  ? 1134 LYS D N    1 
ATOM   2984 C CA   . LYS E 1 56 ? -26.611 17.511 -7.673  1.00 7.37  ? 1134 LYS D CA   1 
ATOM   2985 C C    . LYS E 1 56 ? -25.958 16.899 -8.901  1.00 7.32  ? 1134 LYS D C    1 
ATOM   2986 O O    . LYS E 1 56 ? -25.661 17.588 -9.870  1.00 13.51 ? 1134 LYS D O    1 
ATOM   2987 C CB   . LYS E 1 56 ? -28.131 17.338 -7.759  1.00 5.47  ? 1134 LYS D CB   1 
ATOM   2988 C CG   . LYS E 1 56 ? -28.648 17.857 -9.099  1.00 12.41 ? 1134 LYS D CG   1 
ATOM   2989 C CD   . LYS E 1 56 ? -30.111 18.161 -9.078  1.00 16.16 ? 1134 LYS D CD   1 
ATOM   2990 C CE   . LYS E 1 56 ? -30.628 18.417 -10.490 1.00 19.68 ? 1134 LYS D CE   1 
ATOM   2991 N NZ   . LYS E 1 56 ? -32.087 18.219 -10.381 1.00 27.92 ? 1134 LYS D NZ   1 
ATOM   2992 H H    . LYS E 1 56 ? -26.106 19.299 -8.313  1.00 6.35  ? 1134 LYS D H    1 
ATOM   2993 H HA   . LYS E 1 56 ? -26.265 17.042 -6.897  1.00 8.99  ? 1134 LYS D HA   1 
ATOM   2994 H HB2  . LYS E 1 56 ? -28.356 16.398 -7.682  1.00 6.71  ? 1134 LYS D HB2  1 
ATOM   2995 H HB3  . LYS E 1 56 ? -28.556 17.840 -7.047  1.00 6.71  ? 1134 LYS D HB3  1 
ATOM   2996 H HG2  . LYS E 1 56 ? -28.176 18.673 -9.326  1.00 15.04 ? 1134 LYS D HG2  1 
ATOM   2997 H HG3  . LYS E 1 56 ? -28.492 17.184 -9.781  1.00 15.04 ? 1134 LYS D HG3  1 
ATOM   2998 H HD2  . LYS E 1 56 ? -30.593 17.407 -8.704  1.00 19.54 ? 1134 LYS D HD2  1 
ATOM   2999 H HD3  . LYS E 1 56 ? -30.269 18.954 -8.542  1.00 19.54 ? 1134 LYS D HD3  1 
ATOM   3000 H HE2  . LYS E 1 56 ? -30.433 19.324 -10.774 1.00 23.76 ? 1134 LYS D HE2  1 
ATOM   3001 H HE3  . LYS E 1 56 ? -30.249 17.784 -11.120 1.00 23.76 ? 1134 LYS D HE3  1 
ATOM   3002 H HZ1  . LYS E 1 56 ? -32.514 18.821 -10.879 1.00 33.65 ? 1134 LYS D HZ1  1 
ATOM   3003 H HZ2  . LYS E 1 56 ? -32.305 17.403 -10.663 1.00 33.65 ? 1134 LYS D HZ2  1 
ATOM   3004 H HZ3  . LYS E 1 56 ? -32.344 18.310 -9.534  1.00 33.65 ? 1134 LYS D HZ3  1 
ATOM   3005 N N    . GLY E 1 57 ? -25.822 15.582 -8.884  1.00 7.63  ? 1135 GLY D N    1 
ATOM   3006 C CA   . GLY E 1 57 ? -25.344 14.841 -10.029 1.00 8.20  ? 1135 GLY D CA   1 
ATOM   3007 C C    . GLY E 1 57 ? -24.674 13.548 -9.622  1.00 9.02  ? 1135 GLY D C    1 
ATOM   3008 O O    . GLY E 1 57 ? -24.742 13.117 -8.477  1.00 7.94  ? 1135 GLY D O    1 
ATOM   3009 H H    . GLY E 1 57 ? -26.005 15.087 -8.204  1.00 9.31  ? 1135 GLY D H    1 
ATOM   3010 H HA2  . GLY E 1 57 ? -26.089 14.631 -10.613 1.00 9.99  ? 1135 GLY D HA2  1 
ATOM   3011 H HA3  . GLY E 1 57 ? -24.702 15.380 -10.518 1.00 9.99  ? 1135 GLY D HA3  1 
ATOM   3012 N N    . VAL E 1 58 ? -23.985 12.961 -10.591 1.00 8.56  ? 1136 VAL D N    1 
ATOM   3013 C CA   . VAL E 1 58 ? -23.290 11.690 -10.415 1.00 10.89 ? 1136 VAL D CA   1 
ATOM   3014 C C    . VAL E 1 58 ? -21.900 11.942 -9.818  1.00 10.09 ? 1136 VAL D C    1 
ATOM   3015 O O    . VAL E 1 58 ? -21.224 12.911 -10.173 1.00 6.32  ? 1136 VAL D O    1 
ATOM   3016 C CB   . VAL E 1 58 ? -23.211 10.958 -11.766 1.00 9.78  ? 1136 VAL D CB   1 
ATOM   3017 C CG1  . VAL E 1 58 ? -22.526 9.634  -11.638 1.00 16.56 ? 1136 VAL D CG1  1 
ATOM   3018 C CG2  . VAL E 1 58 ? -24.618 10.772 -12.336 1.00 10.25 ? 1136 VAL D CG2  1 
ATOM   3019 H H    . VAL E 1 58 ? -23.903 13.287 -11.383 1.00 10.42 ? 1136 VAL D H    1 
ATOM   3020 H HA   . VAL E 1 58 ? -23.774 11.135 -9.784  1.00 13.22 ? 1136 VAL D HA   1 
ATOM   3021 H HB   . VAL E 1 58 ? -22.684 11.498 -12.377 1.00 11.89 ? 1136 VAL D HB   1 
ATOM   3022 H HG11 . VAL E 1 58 ? -22.746 9.089  -12.410 1.00 20.02 ? 1136 VAL D HG11 1 
ATOM   3023 H HG12 . VAL E 1 58 ? -21.568 9.777  -11.596 1.00 20.02 ? 1136 VAL D HG12 1 
ATOM   3024 H HG13 . VAL E 1 58 ? -22.832 9.198  -10.828 1.00 20.02 ? 1136 VAL D HG13 1 
ATOM   3025 H HG21 . VAL E 1 58 ? -24.565 10.223 -13.134 1.00 12.45 ? 1136 VAL D HG21 1 
ATOM   3026 H HG22 . VAL E 1 58 ? -25.172 10.335 -11.671 1.00 12.45 ? 1136 VAL D HG22 1 
ATOM   3027 H HG23 . VAL E 1 58 ? -24.987 11.641 -12.556 1.00 12.45 ? 1136 VAL D HG23 1 
ATOM   3028 N N    . PHE E 1 59 ? -21.474 11.081 -8.898  1.00 8.54  ? 1137 PHE D N    1 
ATOM   3029 C CA   . PHE E 1 59 ? -20.203 11.324 -8.238  1.00 7.97  ? 1137 PHE D CA   1 
ATOM   3030 C C    . PHE E 1 59 ? -19.508 10.012 -7.932  1.00 8.62  ? 1137 PHE D C    1 
ATOM   3031 O O    . PHE E 1 59 ? -20.163 8.976  -7.813  1.00 7.13  ? 1137 PHE D O    1 
ATOM   3032 C CB   . PHE E 1 59 ? -20.368 12.131 -6.950  1.00 7.33  ? 1137 PHE D CB   1 
ATOM   3033 C CG   . PHE E 1 59 ? -21.142 11.415 -5.889  1.00 11.19 ? 1137 PHE D CG   1 
ATOM   3034 C CD1  . PHE E 1 59 ? -22.515 11.448 -5.901  1.00 6.99  ? 1137 PHE D CD1  1 
ATOM   3035 C CD2  . PHE E 1 59 ? -20.499 10.672 -4.898  1.00 10.23 ? 1137 PHE D CD2  1 
ATOM   3036 C CE1  . PHE E 1 59 ? -23.248 10.781 -4.950  1.00 9.42  ? 1137 PHE D CE1  1 
ATOM   3037 C CE2  . PHE E 1 59 ? -21.236 10.009 -3.951  1.00 7.26  ? 1137 PHE D CE2  1 
ATOM   3038 C CZ   . PHE E 1 59 ? -22.601 10.072 -3.971  1.00 7.24  ? 1137 PHE D CZ   1 
ATOM   3039 H H    . PHE E 1 59 ? -21.893 10.372 -8.649  1.00 10.40 ? 1137 PHE D H    1 
ATOM   3040 H HA   . PHE E 1 59 ? -19.639 11.820 -8.851  1.00 9.71  ? 1137 PHE D HA   1 
ATOM   3041 H HB2  . PHE E 1 59 ? -19.489 12.332 -6.592  1.00 8.94  ? 1137 PHE D HB2  1 
ATOM   3042 H HB3  . PHE E 1 59 ? -20.838 12.954 -7.156  1.00 8.94  ? 1137 PHE D HB3  1 
ATOM   3043 H HD1  . PHE E 1 59 ? -22.956 11.929 -6.564  1.00 8.54  ? 1137 PHE D HD1  1 
ATOM   3044 H HD2  . PHE E 1 59 ? -19.571 10.627 -4.879  1.00 12.42 ? 1137 PHE D HD2  1 
ATOM   3045 H HE1  . PHE E 1 59 ? -24.178 10.811 -4.969  1.00 11.45 ? 1137 PHE D HE1  1 
ATOM   3046 H HE2  . PHE E 1 59 ? -20.805 9.513  -3.292  1.00 8.86  ? 1137 PHE D HE2  1 
ATOM   3047 H HZ   . PHE E 1 59 ? -23.093 9.631  -3.316  1.00 8.84  ? 1137 PHE D HZ   1 
ATOM   3048 N N    . PRO E 1 60 ? -18.177 10.020 -7.821  1.00 12.09 ? 1138 PRO D N    1 
ATOM   3049 C CA   . PRO E 1 60 ? -17.441 8.769  -7.590  1.00 11.46 ? 1138 PRO D CA   1 
ATOM   3050 C C    . PRO E 1 60 ? -17.546 8.363  -6.127  1.00 12.23 ? 1138 PRO D C    1 
ATOM   3051 O O    . PRO E 1 60 ? -17.341 9.188  -5.234  1.00 9.52  ? 1138 PRO D O    1 
ATOM   3052 C CB   . PRO E 1 60 ? -15.999 9.116  -7.971  1.00 10.76 ? 1138 PRO D CB   1 
ATOM   3053 C CG   . PRO E 1 60 ? -15.922 10.632 -7.986  1.00 9.84  ? 1138 PRO D CG   1 
ATOM   3054 C CD   . PRO E 1 60 ? -17.303 11.202 -7.847  1.00 10.57 ? 1138 PRO D CD   1 
ATOM   3055 H HA   . PRO E 1 60 ? -17.766 8.057  -8.164  1.00 13.89 ? 1138 PRO D HA   1 
ATOM   3056 H HB2  . PRO E 1 60 ? -15.390 8.748  -7.312  1.00 13.06 ? 1138 PRO D HB2  1 
ATOM   3057 H HB3  . PRO E 1 60 ? -15.798 8.754  -8.848  1.00 13.06 ? 1138 PRO D HB3  1 
ATOM   3058 H HG2  . PRO E 1 60 ? -15.368 10.924 -7.245  1.00 11.95 ? 1138 PRO D HG2  1 
ATOM   3059 H HG3  . PRO E 1 60 ? -15.530 10.917 -8.826  1.00 11.95 ? 1138 PRO D HG3  1 
ATOM   3060 H HD2  . PRO E 1 60 ? -17.383 11.705 -7.022  1.00 12.83 ? 1138 PRO D HD2  1 
ATOM   3061 H HD3  . PRO E 1 60 ? -17.517 11.769 -8.604  1.00 12.83 ? 1138 PRO D HD3  1 
ATOM   3062 N N    . VAL E 1 61 ? -17.870 7.087  -5.898  1.00 11.83 ? 1139 VAL D N    1 
ATOM   3063 C CA   . VAL E 1 61 ? -18.028 6.551  -4.541  1.00 11.38 ? 1139 VAL D CA   1 
ATOM   3064 C C    . VAL E 1 61 ? -16.713 6.592  -3.781  1.00 14.89 ? 1139 VAL D C    1 
ATOM   3065 O O    . VAL E 1 61 ? -16.697 6.742  -2.555  1.00 13.62 ? 1139 VAL D O    1 
ATOM   3066 C CB   . VAL E 1 61 ? -18.570 5.110  -4.631  1.00 17.70 ? 1139 VAL D CB   1 
ATOM   3067 C CG1  . VAL E 1 61 ? -18.572 4.418  -3.252  1.00 20.55 ? 1139 VAL D CG1  1 
ATOM   3068 C CG2  . VAL E 1 61 ? -19.965 5.109  -5.248  1.00 17.71 ? 1139 VAL D CG2  1 
ATOM   3069 H H    . VAL E 1 61 ? -18.006 6.505  -6.515  1.00 14.34 ? 1139 VAL D H    1 
ATOM   3070 H HA   . VAL E 1 61 ? -18.662 7.103  -4.057  1.00 13.80 ? 1139 VAL D HA   1 
ATOM   3071 H HB   . VAL E 1 61 ? -17.981 4.595  -5.204  1.00 21.38 ? 1139 VAL D HB   1 
ATOM   3072 H HG11 . VAL E 1 61 ? -19.124 3.622  -3.300  1.00 24.81 ? 1139 VAL D HG11 1 
ATOM   3073 H HG12 . VAL E 1 61 ? -17.662 4.177  -3.019  1.00 24.81 ? 1139 VAL D HG12 1 
ATOM   3074 H HG13 . VAL E 1 61 ? -18.932 5.031  -2.592  1.00 24.81 ? 1139 VAL D HG13 1 
ATOM   3075 H HG21 . VAL E 1 61 ? -20.344 4.220  -5.169  1.00 21.40 ? 1139 VAL D HG21 1 
ATOM   3076 H HG22 . VAL E 1 61 ? -20.520 5.748  -4.775  1.00 21.40 ? 1139 VAL D HG22 1 
ATOM   3077 H HG23 . VAL E 1 61 ? -19.896 5.358  -6.183  1.00 21.40 ? 1139 VAL D HG23 1 
ATOM   3078 N N    . SER E 1 62 ? -15.600 6.438  -4.493  1.00 11.28 ? 1140 SER D N    1 
ATOM   3079 C CA   . SER E 1 62 ? -14.294 6.469  -3.878  1.00 16.71 ? 1140 SER D CA   1 
ATOM   3080 C C    . SER E 1 62 ? -13.947 7.848  -3.359  1.00 14.94 ? 1140 SER D C    1 
ATOM   3081 O O    . SER E 1 62 ? -12.958 7.975  -2.652  1.00 11.97 ? 1140 SER D O    1 
ATOM   3082 C CB   . SER E 1 62 ? -13.238 6.018  -4.878  1.00 12.62 ? 1140 SER D CB   1 
ATOM   3083 O OG   . SER E 1 62 ? -13.244 6.878  -6.022  1.00 16.61 ? 1140 SER D OG   1 
ATOM   3084 H H    . SER E 1 62 ? -15.582 6.312  -5.343  1.00 13.68 ? 1140 SER D H    1 
ATOM   3085 H HA   . SER E 1 62 ? -14.279 5.848  -3.132  1.00 20.20 ? 1140 SER D HA   1 
ATOM   3086 H HB2  . SER E 1 62 ? -12.365 6.054  -4.457  1.00 15.29 ? 1140 SER D HB2  1 
ATOM   3087 H HB3  . SER E 1 62 ? -13.433 5.111  -5.160  1.00 15.29 ? 1140 SER D HB3  1 
ATOM   3088 H HG   . SER E 1 62 ? -12.684 6.608  -6.587  1.00 20.07 ? 1140 SER D HG   1 
ATOM   3089 N N    . PHE E 1 63 ? -14.743 8.873  -3.647  1.00 10.69 ? 1141 PHE D N    1 
ATOM   3090 C CA   . PHE E 1 63 ? -14.453 10.219 -3.164  1.00 7.61  ? 1141 PHE D CA   1 
ATOM   3091 C C    . PHE E 1 63 ? -15.240 10.565 -1.907  1.00 7.74  ? 1141 PHE D C    1 
ATOM   3092 O O    . PHE E 1 63 ? -15.198 11.716 -1.449  1.00 7.66  ? 1141 PHE D O    1 
ATOM   3093 C CB   . PHE E 1 63 ? -14.747 11.244 -4.265  1.00 12.19 ? 1141 PHE D CB   1 
ATOM   3094 C CG   . PHE E 1 63 ? -13.658 11.391 -5.256  1.00 11.05 ? 1141 PHE D CG   1 
ATOM   3095 C CD1  . PHE E 1 63 ? -13.090 10.298 -5.846  1.00 15.72 ? 1141 PHE D CD1  1 
ATOM   3096 C CD2  . PHE E 1 63 ? -13.204 12.636 -5.610  1.00 13.89 ? 1141 PHE D CD2  1 
ATOM   3097 C CE1  . PHE E 1 63 ? -12.068 10.453 -6.790  1.00 16.32 ? 1141 PHE D CE1  1 
ATOM   3098 C CE2  . PHE E 1 63 ? -12.172 12.783 -6.525  1.00 15.55 ? 1141 PHE D CE2  1 
ATOM   3099 C CZ   . PHE E 1 63 ? -11.624 11.690 -7.121  1.00 13.39 ? 1141 PHE D CZ   1 
ATOM   3100 H H    . PHE E 1 63 ? -15.458 8.813  -4.122  1.00 12.97 ? 1141 PHE D H    1 
ATOM   3101 H HA   . PHE E 1 63 ? -13.509 10.277 -2.948  1.00 9.28  ? 1141 PHE D HA   1 
ATOM   3102 H HB2  . PHE E 1 63 ? -15.545 10.968 -4.743  1.00 14.77 ? 1141 PHE D HB2  1 
ATOM   3103 H HB3  . PHE E 1 63 ? -14.890 12.111 -3.854  1.00 14.77 ? 1141 PHE D HB3  1 
ATOM   3104 H HD1  . PHE E 1 63 ? -13.384 9.445  -5.619  1.00 19.01 ? 1141 PHE D HD1  1 
ATOM   3105 H HD2  . PHE E 1 63 ? -13.593 13.392 -5.231  1.00 16.81 ? 1141 PHE D HD2  1 
ATOM   3106 H HE1  . PHE E 1 63 ? -11.692 9.704  -7.192  1.00 19.73 ? 1141 PHE D HE1  1 
ATOM   3107 H HE2  . PHE E 1 63 ? -11.853 13.632 -6.731  1.00 18.81 ? 1141 PHE D HE2  1 
ATOM   3108 H HZ   . PHE E 1 63 ? -10.948 11.791 -7.751  1.00 16.21 ? 1141 PHE D HZ   1 
ATOM   3109 N N    . VAL E 1 64 ? -15.946 9.598  -1.332  1.00 8.37  ? 1142 VAL D N    1 
ATOM   3110 C CA   . VAL E 1 64 ? -16.787 9.870  -0.178  1.00 10.18 ? 1142 VAL D CA   1 
ATOM   3111 C C    . VAL E 1 64 ? -16.627 8.805  0.900   1.00 9.54  ? 1142 VAL D C    1 
ATOM   3112 O O    . VAL E 1 64 ? -16.270 7.653  0.645   1.00 9.36  ? 1142 VAL D O    1 
ATOM   3113 C CB   . VAL E 1 64 ? -18.270 9.966  -0.568  1.00 5.69  ? 1142 VAL D CB   1 
ATOM   3114 C CG1  . VAL E 1 64 ? -18.438 10.871 -1.812  1.00 9.50  ? 1142 VAL D CG1  1 
ATOM   3115 C CG2  . VAL E 1 64 ? -18.822 8.585  -0.806  1.00 6.94  ? 1142 VAL D CG2  1 
ATOM   3116 H H    . VAL E 1 64 ? -15.953 8.779  -1.593  1.00 10.19 ? 1142 VAL D H    1 
ATOM   3117 H HA   . VAL E 1 64 ? -16.482 10.706 0.207   1.00 12.36 ? 1142 VAL D HA   1 
ATOM   3118 H HB   . VAL E 1 64 ? -18.777 10.369 0.154   1.00 6.97  ? 1142 VAL D HB   1 
ATOM   3119 H HG11 . VAL E 1 64 ? -19.383 11.032 -1.959  1.00 11.55 ? 1142 VAL D HG11 1 
ATOM   3120 H HG12 . VAL E 1 64 ? -17.980 11.711 -1.655  1.00 11.55 ? 1142 VAL D HG12 1 
ATOM   3121 H HG13 . VAL E 1 64 ? -18.054 10.424 -2.582  1.00 11.55 ? 1142 VAL D HG13 1 
ATOM   3122 H HG21 . VAL E 1 64 ? -19.603 8.651  -1.378  1.00 8.47  ? 1142 VAL D HG21 1 
ATOM   3123 H HG22 . VAL E 1 64 ? -18.142 8.043  -1.237  1.00 8.47  ? 1142 VAL D HG22 1 
ATOM   3124 H HG23 . VAL E 1 64 ? -19.067 8.191  0.046   1.00 8.47  ? 1142 VAL D HG23 1 
ATOM   3125 N N    . HIS E 1 65 ? -16.970 9.195  2.112   1.00 8.94  ? 1143 HIS D N    1 
ATOM   3126 C CA   . HIS E 1 65 ? -17.061 8.248  3.209   1.00 16.42 ? 1143 HIS D CA   1 
ATOM   3127 C C    . HIS E 1 65 ? -18.518 8.088  3.597   1.00 13.32 ? 1143 HIS D C    1 
ATOM   3128 O O    . HIS E 1 65 ? -19.223 9.077  3.783   1.00 10.80 ? 1143 HIS D O    1 
ATOM   3129 C CB   . HIS E 1 65 ? -16.231 8.716  4.407   1.00 16.33 ? 1143 HIS D CB   1 
ATOM   3130 C CG   . HIS E 1 65 ? -14.808 8.251  4.361   1.00 34.02 ? 1143 HIS D CG   1 
ATOM   3131 N ND1  . HIS E 1 65 ? -13.915 8.464  5.393   1.00 34.05 ? 1143 HIS D ND1  1 
ATOM   3132 C CD2  . HIS E 1 65 ? -14.124 7.573  3.408   1.00 33.23 ? 1143 HIS D CD2  1 
ATOM   3133 C CE1  . HIS E 1 65 ? -12.745 7.940  5.076   1.00 28.38 ? 1143 HIS D CE1  1 
ATOM   3134 N NE2  . HIS E 1 65 ? -12.845 7.395  3.877   1.00 30.72 ? 1143 HIS D NE2  1 
ATOM   3135 H H    . HIS E 1 65 ? -17.156 10.007 2.327   1.00 10.88 ? 1143 HIS D H    1 
ATOM   3136 H HA   . HIS E 1 65 ? -16.718 7.382  2.940   1.00 19.85 ? 1143 HIS D HA   1 
ATOM   3137 H HB2  . HIS E 1 65 ? -16.227 9.686  4.427   1.00 19.74 ? 1143 HIS D HB2  1 
ATOM   3138 H HB3  . HIS E 1 65 ? -16.631 8.369  5.220   1.00 19.74 ? 1143 HIS D HB3  1 
ATOM   3139 H HD2  . HIS E 1 65 ? -14.458 7.283  2.590   1.00 40.02 ? 1143 HIS D HD2  1 
ATOM   3140 H HE1  . HIS E 1 65 ? -11.982 7.952  5.606   1.00 34.20 ? 1143 HIS D HE1  1 
ATOM   3141 H HE2  . HIS E 1 65 ? -12.211 6.993  3.457   1.00 37.01 ? 1143 HIS D HE2  1 
ATOM   3142 N N    . ILE E 1 66 ? -18.941 6.840  3.774   1.00 14.80 ? 1144 ILE D N    1 
ATOM   3143 C CA   . ILE E 1 66 ? -20.306 6.585  4.198   1.00 20.37 ? 1144 ILE D CA   1 
ATOM   3144 C C    . ILE E 1 66 ? -20.541 7.167  5.582   1.00 23.43 ? 1144 ILE D C    1 
ATOM   3145 O O    . ILE E 1 66 ? -19.774 6.918  6.525   1.00 24.27 ? 1144 ILE D O    1 
ATOM   3146 C CB   . ILE E 1 66 ? -20.597 5.080  4.185   1.00 20.47 ? 1144 ILE D CB   1 
ATOM   3147 C CG1  . ILE E 1 66 ? -20.871 4.568  2.769   1.00 23.38 ? 1144 ILE D CG1  1 
ATOM   3148 C CG2  . ILE E 1 66 ? -21.820 4.802  5.053   1.00 27.45 ? 1144 ILE D CG2  1 
ATOM   3149 C CD1  . ILE E 1 66 ? -19.670 4.569  1.882   1.00 36.14 ? 1144 ILE D CD1  1 
ATOM   3150 H H    . ILE E 1 66 ? -18.462 6.135  3.656   1.00 17.91 ? 1144 ILE D H    1 
ATOM   3151 H HA   . ILE E 1 66 ? -20.905 7.026  3.574   1.00 24.59 ? 1144 ILE D HA   1 
ATOM   3152 H HB   . ILE E 1 66 ? -19.814 4.623  4.528   1.00 24.71 ? 1144 ILE D HB   1 
ATOM   3153 H HG12 . ILE E 1 66 ? -21.195 3.656  2.826   1.00 28.21 ? 1144 ILE D HG12 1 
ATOM   3154 H HG13 . ILE E 1 66 ? -21.542 5.134  2.358   1.00 28.21 ? 1144 ILE D HG13 1 
ATOM   3155 H HG21 . ILE E 1 66 ? -22.045 3.861  4.990   1.00 33.09 ? 1144 ILE D HG21 1 
ATOM   3156 H HG22 . ILE E 1 66 ? -21.613 5.032  5.973   1.00 33.09 ? 1144 ILE D HG22 1 
ATOM   3157 H HG23 . ILE E 1 66 ? -22.562 5.341  4.736   1.00 33.09 ? 1144 ILE D HG23 1 
ATOM   3158 H HD11 . ILE E 1 66 ? -19.920 4.217  1.013   1.00 43.52 ? 1144 ILE D HD11 1 
ATOM   3159 H HD12 . ILE E 1 66 ? -19.347 5.479  1.789   1.00 43.52 ? 1144 ILE D HD12 1 
ATOM   3160 H HD13 . ILE E 1 66 ? -18.983 4.013  2.280   1.00 43.52 ? 1144 ILE D HD13 1 
ATOM   3161 N N    . LEU E 1 67 ? -21.629 7.928  5.712   1.00 17.92 ? 1145 LEU D N    1 
ATOM   3162 C CA   . LEU E 1 67 ? -22.020 8.616  6.935   1.00 20.61 ? 1145 LEU D CA   1 
ATOM   3163 C C    . LEU E 1 67 ? -23.392 8.182  7.429   1.00 30.63 ? 1145 LEU D C    1 
ATOM   3164 O O    . LEU E 1 67 ? -23.538 7.780  8.584   1.00 37.90 ? 1145 LEU D O    1 
ATOM   3165 C CB   . LEU E 1 67 ? -21.993 10.121 6.645   1.00 22.86 ? 1145 LEU D CB   1 
ATOM   3166 C CG   . LEU E 1 67 ? -21.699 11.215 7.648   1.00 27.45 ? 1145 LEU D CG   1 
ATOM   3167 C CD1  . LEU E 1 67 ? -20.254 11.253 8.017   1.00 21.35 ? 1145 LEU D CD1  1 
ATOM   3168 C CD2  . LEU E 1 67 ? -22.157 12.518 6.958   1.00 18.75 ? 1145 LEU D CD2  1 
ATOM   3169 H H    . LEU E 1 67 ? -22.183 8.066  5.070   1.00 21.65 ? 1145 LEU D H    1 
ATOM   3170 H HA   . LEU E 1 67 ? -21.398 8.422  7.654   1.00 24.88 ? 1145 LEU D HA   1 
ATOM   3171 H HB2  . LEU E 1 67 ? -21.327 10.243 5.951   1.00 27.58 ? 1145 LEU D HB2  1 
ATOM   3172 H HB3  . LEU E 1 67 ? -22.874 10.338 6.302   1.00 27.58 ? 1145 LEU D HB3  1 
ATOM   3173 H HG   . LEU E 1 67 ? -22.160 11.080 8.491   1.00 33.08 ? 1145 LEU D HG   1 
ATOM   3174 H HD11 . LEU E 1 67 ? -20.123 11.921 8.709   1.00 25.77 ? 1145 LEU D HD11 1 
ATOM   3175 H HD12 . LEU E 1 67 ? -19.989 10.380 8.345   1.00 25.77 ? 1145 LEU D HD12 1 
ATOM   3176 H HD13 . LEU E 1 67 ? -19.734 11.484 7.232   1.00 25.77 ? 1145 LEU D HD13 1 
ATOM   3177 H HD21 . LEU E 1 67 ? -21.856 13.276 7.483   1.00 22.64 ? 1145 LEU D HD21 1 
ATOM   3178 H HD22 . LEU E 1 67 ? -21.770 12.558 6.069   1.00 22.64 ? 1145 LEU D HD22 1 
ATOM   3179 H HD23 . LEU E 1 67 ? -23.125 12.521 6.897   1.00 22.64 ? 1145 LEU D HD23 1 
ATOM   3180 N N    . SER E 1 68 ? -24.406 8.265  6.563   1.00 35.91 ? 1146 SER D N    1 
ATOM   3181 C CA   . SER E 1 68 ? -25.818 7.995  6.834   1.00 27.83 ? 1146 SER D CA   1 
ATOM   3182 C C    . SER E 1 68 ? -26.272 8.523  8.197   1.00 34.41 ? 1146 SER D C    1 
ATOM   3183 O O    . SER E 1 68 ? -26.336 9.735  8.398   1.00 24.92 ? 1146 SER D O    1 
ATOM   3184 C CB   . SER E 1 68 ? -26.081 6.511  6.704   1.00 32.41 ? 1146 SER D CB   1 
ATOM   3185 O OG   . SER E 1 68 ? -26.259 6.199  5.337   1.00 31.80 ? 1146 SER D OG   1 
ATOM   3186 H H    . SER E 1 68 ? -24.292 8.495  5.742   1.00 43.24 ? 1146 SER D H    1 
ATOM   3187 H HA   . SER E 1 68 ? -26.359 8.464  6.180   1.00 33.55 ? 1146 SER D HA   1 
ATOM   3188 H HB2  . SER E 1 68 ? -25.324 6.015  7.054   1.00 39.04 ? 1146 SER D HB2  1 
ATOM   3189 H HB3  . SER E 1 68 ? -26.885 6.280  7.197   1.00 39.04 ? 1146 SER D HB3  1 
ATOM   3190 H HG   . SER E 1 68 ? -26.410 5.377  5.247   1.00 38.31 ? 1146 SER D HG   1 
ATOM   3191 N N    . ILE F 2 2  ? -5.653  11.401 -5.720  1.00 53.42 ? 1700 ILE F N    1 
ATOM   3192 C CA   . ILE F 2 2  ? -6.346  10.164 -6.048  1.00 50.52 ? 1700 ILE F CA   1 
ATOM   3193 C C    . ILE F 2 2  ? -6.927  10.267 -7.470  1.00 48.40 ? 1700 ILE F C    1 
ATOM   3194 O O    . ILE F 2 2  ? -7.283  11.361 -7.932  1.00 46.04 ? 1700 ILE F O    1 
ATOM   3195 C CB   . ILE F 2 2  ? -7.445  9.860  -5.020  1.00 46.16 ? 1700 ILE F CB   1 
ATOM   3196 C CG1  . ILE F 2 2  ? -7.898  8.405  -5.174  1.00 51.10 ? 1700 ILE F CG1  1 
ATOM   3197 C CG2  . ILE F 2 2  ? -8.603  10.838 -5.175  1.00 39.44 ? 1700 ILE F CG2  1 
ATOM   3198 C CD1  . ILE F 2 2  ? -6.987  7.408  -4.446  1.00 59.44 ? 1700 ILE F CD1  1 
ATOM   3199 H HA   . ILE F 2 2  ? -5.718  9.426  -6.024  1.00 60.77 ? 1700 ILE F HA   1 
ATOM   3200 H HB   . ILE F 2 2  ? -7.093  9.973  -4.124  1.00 55.54 ? 1700 ILE F HB   1 
ATOM   3201 H HG12 . ILE F 2 2  ? -8.792  8.314  -4.809  1.00 61.46 ? 1700 ILE F HG12 1 
ATOM   3202 H HG13 . ILE F 2 2  ? -7.899  8.174  -6.116  1.00 61.46 ? 1700 ILE F HG13 1 
ATOM   3203 H HG21 . ILE F 2 2  ? -9.224  10.712 -4.441  1.00 47.47 ? 1700 ILE F HG21 1 
ATOM   3204 H HG22 . ILE F 2 2  ? -8.256  11.744 -5.162  1.00 47.47 ? 1700 ILE F HG22 1 
ATOM   3205 H HG23 . ILE F 2 2  ? -9.050  10.668 -6.019  1.00 47.47 ? 1700 ILE F HG23 1 
ATOM   3206 H HD11 . ILE F 2 2  ? -7.331  6.510  -4.579  1.00 71.48 ? 1700 ILE F HD11 1 
ATOM   3207 H HD12 . ILE F 2 2  ? -6.090  7.475  -4.809  1.00 71.48 ? 1700 ILE F HD12 1 
ATOM   3208 H HD13 . ILE F 2 2  ? -6.978  7.621  -3.500  1.00 71.48 ? 1700 ILE F HD13 1 
ATOM   3209 N N    . LYS F 2 3  ? -7.016  9.126  -8.156  1.00 45.08 ? 1701 LYS F N    1 
ATOM   3210 C CA   . LYS F 2 3  ? -7.538  9.066  -9.516  1.00 34.75 ? 1701 LYS F CA   1 
ATOM   3211 C C    . LYS F 2 3  ? -9.025  8.718  -9.505  1.00 28.81 ? 1701 LYS F C    1 
ATOM   3212 O O    . LYS F 2 3  ? -9.457  7.800  -8.803  1.00 25.53 ? 1701 LYS F O    1 
ATOM   3213 C CB   . LYS F 2 3  ? -6.786  8.022  -10.351 1.00 32.50 ? 1701 LYS F CB   1 
ATOM   3214 H H    . LYS F 2 3  ? -6.775  8.360  -7.847  1.00 54.25 ? 1701 LYS F H    1 
ATOM   3215 H HA   . LYS F 2 3  ? -7.422  9.935  -9.929  1.00 41.84 ? 1701 LYS F HA   1 
ATOM   3216 N N    . LYS F 2 4  ? -9.788  9.430  -10.337 1.00 27.00 ? 1702 LYS F N    1 
ATOM   3217 C CA   . LYS F 2 4  ? -11.226 9.249  -10.503 1.00 25.51 ? 1702 LYS F CA   1 
ATOM   3218 C C    . LYS F 2 4  ? -11.486 8.019  -11.368 1.00 21.17 ? 1702 LYS F C    1 
ATOM   3219 O O    . LYS F 2 4  ? -10.803 7.820  -12.370 1.00 30.03 ? 1702 LYS F O    1 
ATOM   3220 C CB   . LYS F 2 4  ? -11.789 10.507 -11.157 1.00 23.26 ? 1702 LYS F CB   1 
ATOM   3221 C CG   . LYS F 2 4  ? -13.215 10.850 -10.912 1.00 26.22 ? 1702 LYS F CG   1 
ATOM   3222 C CD   . LYS F 2 4  ? -13.623 12.043 -11.796 1.00 12.33 ? 1702 LYS F CD   1 
ATOM   3223 C CE   . LYS F 2 4  ? -13.372 13.389 -11.118 1.00 12.45 ? 1702 LYS F CE   1 
ATOM   3224 N NZ   . LYS F 2 4  ? -13.954 14.547 -11.831 1.00 17.21 ? 1702 LYS F NZ   1 
ATOM   3225 H H    . LYS F 2 4  ? -9.479  10.055 -10.840 1.00 32.54 ? 1702 LYS F H    1 
ATOM   3226 H HA   . LYS F 2 4  ? -11.674 9.106  -9.654  1.00 30.75 ? 1702 LYS F HA   1 
ATOM   3227 H HB2  . LYS F 2 4  ? -11.265 11.261 -10.843 1.00 28.06 ? 1702 LYS F HB2  1 
ATOM   3228 H HB3  . LYS F 2 4  ? -11.688 10.409 -12.116 1.00 28.06 ? 1702 LYS F HB3  1 
ATOM   3229 H HG2  . LYS F 2 4  ? -13.778 10.091 -11.133 1.00 31.61 ? 1702 LYS F HG2  1 
ATOM   3230 H HG3  . LYS F 2 4  ? -13.339 11.095 -9.982  1.00 31.61 ? 1702 LYS F HG3  1 
ATOM   3231 H HD2  . LYS F 2 4  ? -13.107 12.019 -12.617 1.00 14.94 ? 1702 LYS F HD2  1 
ATOM   3232 H HD3  . LYS F 2 4  ? -14.570 11.980 -11.997 1.00 14.94 ? 1702 LYS F HD3  1 
ATOM   3233 H HE2  . LYS F 2 4  ? -13.760 13.366 -10.230 1.00 15.09 ? 1702 LYS F HE2  1 
ATOM   3234 H HE3  . LYS F 2 4  ? -12.414 13.533 -11.059 1.00 15.09 ? 1702 LYS F HE3  1 
ATOM   3235 H HZ1  . LYS F 2 4  ? -13.573 14.636 -12.631 1.00 20.80 ? 1702 LYS F HZ1  1 
ATOM   3236 H HZ2  . LYS F 2 4  ? -13.819 15.292 -11.363 1.00 20.80 ? 1702 LYS F HZ2  1 
ATOM   3237 H HZ3  . LYS F 2 4  ? -14.829 14.429 -11.939 1.00 20.80 ? 1702 LYS F HZ3  1 
ATOM   3238 N N    . PRO F 2 5  ? -12.375 7.124  -10.973 1.00 20.98 ? 1703 PRO F N    1 
ATOM   3239 C CA   . PRO F 2 5  ? -12.705 6.001  -11.851 1.00 25.60 ? 1703 PRO F CA   1 
ATOM   3240 C C    . PRO F 2 5  ? -13.364 6.511  -13.124 1.00 33.14 ? 1703 PRO F C    1 
ATOM   3241 O O    . PRO F 2 5  ? -13.881 7.630  -13.176 1.00 27.63 ? 1703 PRO F O    1 
ATOM   3242 C CB   . PRO F 2 5  ? -13.676 5.166  -11.010 1.00 28.20 ? 1703 PRO F CB   1 
ATOM   3243 C CG   . PRO F 2 5  ? -14.289 6.166  -10.055 1.00 27.12 ? 1703 PRO F CG   1 
ATOM   3244 C CD   . PRO F 2 5  ? -13.149 7.089  -9.723  1.00 24.30 ? 1703 PRO F CD   1 
ATOM   3245 H HA   . PRO F 2 5  ? -11.925 5.465  -12.064 1.00 30.86 ? 1703 PRO F HA   1 
ATOM   3246 H HB2  . PRO F 2 5  ? -14.352 4.765  -11.579 1.00 33.99 ? 1703 PRO F HB2  1 
ATOM   3247 H HB3  . PRO F 2 5  ? -13.193 4.474  -10.531 1.00 33.99 ? 1703 PRO F HB3  1 
ATOM   3248 H HG2  . PRO F 2 5  ? -15.013 6.644  -10.489 1.00 32.68 ? 1703 PRO F HG2  1 
ATOM   3249 H HG3  . PRO F 2 5  ? -14.618 5.715  -9.262  1.00 32.68 ? 1703 PRO F HG3  1 
ATOM   3250 H HD2  . PRO F 2 5  ? -13.475 7.973  -9.493  1.00 29.30 ? 1703 PRO F HD2  1 
ATOM   3251 H HD3  . PRO F 2 5  ? -12.615 6.732  -8.996  1.00 29.30 ? 1703 PRO F HD3  1 
ATOM   3252 N N    . VAL F 2 6  ? -13.315 5.690  -14.174 1.00 35.62 ? 1704 VAL F N    1 
ATOM   3253 C CA   . VAL F 2 6  ? -13.891 6.105  -15.446 1.00 38.10 ? 1704 VAL F CA   1 
ATOM   3254 C C    . VAL F 2 6  ? -15.393 5.914  -15.360 1.00 36.41 ? 1704 VAL F C    1 
ATOM   3255 O O    . VAL F 2 6  ? -15.892 4.990  -14.698 1.00 33.40 ? 1704 VAL F O    1 
ATOM   3256 C CB   . VAL F 2 6  ? -13.296 5.333  -16.643 1.00 40.26 ? 1704 VAL F CB   1 
ATOM   3257 C CG1  . VAL F 2 6  ? -11.964 5.979  -17.061 1.00 44.90 ? 1704 VAL F CG1  1 
ATOM   3258 C CG2  . VAL F 2 6  ? -13.133 3.856  -16.310 1.00 43.90 ? 1704 VAL F CG2  1 
ATOM   3259 H H    . VAL F 2 6  ? -12.960 4.907  -14.173 1.00 42.89 ? 1704 VAL F H    1 
ATOM   3260 H HA   . VAL F 2 6  ? -13.681 7.041  -15.593 1.00 45.87 ? 1704 VAL F HA   1 
ATOM   3261 H HB   . VAL F 2 6  ? -13.903 5.381  -17.398 1.00 48.46 ? 1704 VAL F HB   1 
ATOM   3262 H HG11 . VAL F 2 6  ? -11.592 5.483  -17.807 1.00 54.03 ? 1704 VAL F HG11 1 
ATOM   3263 H HG12 . VAL F 2 6  ? -12.127 6.899  -17.324 1.00 54.03 ? 1704 VAL F HG12 1 
ATOM   3264 H HG13 . VAL F 2 6  ? -11.351 5.954  -16.310 1.00 54.03 ? 1704 VAL F HG13 1 
ATOM   3265 H HG21 . VAL F 2 6  ? -12.790 3.393  -17.090 1.00 52.83 ? 1704 VAL F HG21 1 
ATOM   3266 H HG22 . VAL F 2 6  ? -12.511 3.766  -15.571 1.00 52.83 ? 1704 VAL F HG22 1 
ATOM   3267 H HG23 . VAL F 2 6  ? -13.996 3.491  -16.062 1.00 52.83 ? 1704 VAL F HG23 1 
ATOM   3268 N N    . ARG F 2 7  ? -16.115 6.796  -16.045 1.00 36.00 ? 1705 ARG F N    1 
ATOM   3269 C CA   . ARG F 2 7  ? -17.548 6.630  -16.213 1.00 34.01 ? 1705 ARG F CA   1 
ATOM   3270 C C    . ARG F 2 7  ? -17.830 5.565  -17.258 1.00 38.56 ? 1705 ARG F C    1 
ATOM   3271 O O    . ARG F 2 7  ? -17.124 5.466  -18.264 1.00 45.76 ? 1705 ARG F O    1 
ATOM   3272 C CB   . ARG F 2 7  ? -18.241 7.932  -16.655 1.00 33.46 ? 1705 ARG F CB   1 
ATOM   3273 C CG   . ARG F 2 7  ? -18.287 9.063  -15.675 1.00 18.38 ? 1705 ARG F CG   1 
ATOM   3274 C CD   . ARG F 2 7  ? -19.399 8.914  -14.636 1.00 20.14 ? 1705 ARG F CD   1 
ATOM   3275 N NE   . ARG F 2 7  ? -20.743 8.759  -15.163 1.00 13.25 ? 1705 ARG F NE   1 
ATOM   3276 C CZ   . ARG F 2 7  ? -21.522 9.783  -15.468 1.00 10.16 ? 1705 ARG F CZ   1 
ATOM   3277 N NH1  . ARG F 2 7  ? -21.042 11.012 -15.527 1.00 11.00 ? 1705 ARG F NH1  1 
ATOM   3278 N NH2  . ARG F 2 7  ? -22.803 9.563  -15.758 1.00 14.80 ? 1705 ARG F NH2  1 
ATOM   3279 H H    . ARG F 2 7  ? -15.795 7.499  -16.423 1.00 43.35 ? 1705 ARG F H    1 
ATOM   3280 H HA   . ARG F 2 7  ? -17.917 6.371  -15.354 1.00 40.96 ? 1705 ARG F HA   1 
ATOM   3281 H HB2  . ARG F 2 7  ? -17.778 8.262  -17.441 1.00 40.30 ? 1705 ARG F HB2  1 
ATOM   3282 H HB3  . ARG F 2 7  ? -19.160 7.717  -16.877 1.00 40.30 ? 1705 ARG F HB3  1 
ATOM   3283 H HG2  . ARG F 2 7  ? -17.441 9.104  -15.202 1.00 22.20 ? 1705 ARG F HG2  1 
ATOM   3284 H HG3  . ARG F 2 7  ? -18.438 9.891  -16.157 1.00 22.20 ? 1705 ARG F HG3  1 
ATOM   3285 H HD2  . ARG F 2 7  ? -19.210 8.129  -14.098 1.00 24.31 ? 1705 ARG F HD2  1 
ATOM   3286 H HD3  . ARG F 2 7  ? -19.401 9.706  -14.076 1.00 24.31 ? 1705 ARG F HD3  1 
ATOM   3287 H HE   . ARG F 2 7  ? -21.046 7.963  -15.284 1.00 16.04 ? 1705 ARG F HE   1 
ATOM   3288 H HH11 . ARG F 2 7  ? -20.210 11.157 -15.366 1.00 13.35 ? 1705 ARG F HH11 1 
ATOM   3289 H HH12 . ARG F 2 7  ? -21.562 11.667 -15.726 1.00 13.35 ? 1705 ARG F HH12 1 
ATOM   3290 H HH21 . ARG F 2 7  ? -23.115 8.761  -15.746 1.00 17.90 ? 1705 ARG F HH21 1 
ATOM   3291 H HH22 . ARG F 2 7  ? -23.318 10.222 -15.957 1.00 17.90 ? 1705 ARG F HH22 1 
ATOM   3292 N N    . ARG F 2 8  ? -18.852 4.756  -17.009 1.00 40.81 ? 1706 ARG F N    1 
ATOM   3293 C CA   . ARG F 2 8  ? -19.363 3.865  -18.049 1.00 58.18 ? 1706 ARG F CA   1 
ATOM   3294 C C    . ARG F 2 8  ? -19.913 4.666  -19.233 1.00 53.31 ? 1706 ARG F C    1 
ATOM   3295 O O    . ARG F 2 8  ? -19.198 4.968  -20.192 1.00 60.61 ? 1706 ARG F O    1 
ATOM   3296 C CB   . ARG F 2 8  ? -20.456 2.960  -17.497 1.00 63.54 ? 1706 ARG F CB   1 
ATOM   3297 C CG   . ARG F 2 8  ? -20.825 1.853  -18.440 1.00 67.54 ? 1706 ARG F CG   1 
ATOM   3298 C CD   . ARG F 2 8  ? -20.237 0.505  -17.995 1.00 82.24 ? 1706 ARG F CD   1 
ATOM   3299 N NE   . ARG F 2 8  ? -20.731 -0.531 -18.890 1.00 82.82 ? 1706 ARG F NE   1 
ATOM   3300 C CZ   . ARG F 2 8  ? -21.367 -1.629 -18.504 1.00 76.98 ? 1706 ARG F CZ   1 
ATOM   3301 N NH1  . ARG F 2 8  ? -21.482 -1.950 -17.224 1.00 68.46 ? 1706 ARG F NH1  1 
ATOM   3302 N NH2  . ARG F 2 8  ? -21.925 -2.412 -19.425 1.00 72.24 ? 1706 ARG F NH2  1 
ATOM   3303 H H    . ARG F 2 8  ? -19.263 4.702  -16.255 1.00 49.12 ? 1706 ARG F H    1 
ATOM   3304 H HA   . ARG F 2 8  ? -18.636 3.306  -18.365 1.00 69.96 ? 1706 ARG F HA   1 
ATOM   3305 H HB2  . ARG F 2 8  ? -20.145 2.559  -16.670 1.00 76.40 ? 1706 ARG F HB2  1 
ATOM   3306 H HB3  . ARG F 2 8  ? -21.251 3.491  -17.330 1.00 76.40 ? 1706 ARG F HB3  1 
ATOM   3307 H HG2  . ARG F 2 8  ? -21.791 1.768  -18.472 1.00 81.19 ? 1706 ARG F HG2  1 
ATOM   3308 H HG3  . ARG F 2 8  ? -20.481 2.057  -19.324 1.00 81.19 ? 1706 ARG F HG3  1 
ATOM   3309 H HD2  . ARG F 2 8  ? -19.269 0.532  -18.044 1.00 98.84 ? 1706 ARG F HD2  1 
ATOM   3310 H HD3  . ARG F 2 8  ? -20.518 0.303  -17.088 1.00 98.84 ? 1706 ARG F HD3  1 
ATOM   3311 H HE   . ARG F 2 8  ? -20.601 -0.423 -19.733 1.00 99.53 ? 1706 ARG F HE   1 
ATOM   3312 H HH11 . ARG F 2 8  ? -21.140 -1.441 -16.621 1.00 82.30 ? 1706 ARG F HH11 1 
ATOM   3313 H HH12 . ARG F 2 8  ? -21.899 -2.667 -16.997 1.00 82.30 ? 1706 ARG F HH12 1 
ATOM   3314 H HH21 . ARG F 2 8  ? -21.871 -2.203 -20.257 1.00 86.83 ? 1706 ARG F HH21 1 
ATOM   3315 H HH22 . ARG F 2 8  ? -22.340 -3.127 -19.187 1.00 86.83 ? 1706 ARG F HH22 1 
ATOM   3316 N N    . LYS G 1 8  ? -8.297  33.307 2.691   1.00 38.51 ? 1086 LYS G N    1 
ATOM   3317 C CA   . LYS G 1 8  ? -9.159  32.146 2.808   1.00 40.81 ? 1086 LYS G CA   1 
ATOM   3318 C C    . LYS G 1 8  ? -8.449  30.837 2.459   1.00 31.98 ? 1086 LYS G C    1 
ATOM   3319 O O    . LYS G 1 8  ? -8.799  30.183 1.467   1.00 27.96 ? 1086 LYS G O    1 
ATOM   3320 C CB   . LYS G 1 8  ? -10.392 32.322 1.915   1.00 42.59 ? 1086 LYS G CB   1 
ATOM   3321 H HA   . LYS G 1 8  ? -9.438  32.073 3.734   1.00 49.12 ? 1086 LYS G HA   1 
ATOM   3322 N N    . VAL G 1 9  ? -7.499  30.422 3.302   1.00 28.19 ? 1087 VAL G N    1 
ATOM   3323 C CA   . VAL G 1 9  ? -6.685  29.239 3.012   1.00 26.13 ? 1087 VAL G CA   1 
ATOM   3324 C C    . VAL G 1 9  ? -7.471  27.973 3.342   1.00 16.86 ? 1087 VAL G C    1 
ATOM   3325 O O    . VAL G 1 9  ? -7.963  27.796 4.465   1.00 26.13 ? 1087 VAL G O    1 
ATOM   3326 C CB   . VAL G 1 9  ? -5.365  29.271 3.799   1.00 20.99 ? 1087 VAL G CB   1 
ATOM   3327 C CG1  . VAL G 1 9  ? -4.599  27.962 3.593   1.00 17.22 ? 1087 VAL G CG1  1 
ATOM   3328 C CG2  . VAL G 1 9  ? -4.543  30.456 3.379   1.00 25.89 ? 1087 VAL G CG2  1 
ATOM   3329 H H    . VAL G 1 9  ? -7.307  30.807 4.047   1.00 33.97 ? 1087 VAL G H    1 
ATOM   3330 H HA   . VAL G 1 9  ? -6.485  29.236 2.062   1.00 31.50 ? 1087 VAL G HA   1 
ATOM   3331 H HB   . VAL G 1 9  ? -5.551  29.360 4.747   1.00 25.33 ? 1087 VAL G HB   1 
ATOM   3332 H HG11 . VAL G 1 9  ? -3.669  28.099 3.829   1.00 20.81 ? 1087 VAL G HG11 1 
ATOM   3333 H HG12 . VAL G 1 9  ? -4.987  27.276 4.159   1.00 20.81 ? 1087 VAL G HG12 1 
ATOM   3334 H HG13 . VAL G 1 9  ? -4.668  27.699 2.661   1.00 20.81 ? 1087 VAL G HG13 1 
ATOM   3335 H HG21 . VAL G 1 9  ? -3.718  30.464 3.887   1.00 31.21 ? 1087 VAL G HG21 1 
ATOM   3336 H HG22 . VAL G 1 9  ? -4.347  30.384 2.431   1.00 31.21 ? 1087 VAL G HG22 1 
ATOM   3337 H HG23 . VAL G 1 9  ? -5.047  31.267 3.552   1.00 31.21 ? 1087 VAL G HG23 1 
ATOM   3338 N N    . ARG G 1 10 ? -7.506  27.039 2.408   1.00 13.82 ? 1088 ARG G N    1 
ATOM   3339 C CA   . ARG G 1 10 ? -8.250  25.815 2.661   1.00 18.00 ? 1088 ARG G CA   1 
ATOM   3340 C C    . ARG G 1 10 ? -7.411  24.557 2.585   1.00 17.76 ? 1088 ARG G C    1 
ATOM   3341 O O    . ARG G 1 10 ? -7.642  23.634 3.367   1.00 11.01 ? 1088 ARG G O    1 
ATOM   3342 C CB   . ARG G 1 10 ? -9.437  25.673 1.687   1.00 18.24 ? 1088 ARG G CB   1 
ATOM   3343 C CG   . ARG G 1 10 ? -10.233 24.357 1.873   1.00 17.68 ? 1088 ARG G CG   1 
ATOM   3344 C CD   . ARG G 1 10 ? -11.501 24.303 0.971   1.00 14.75 ? 1088 ARG G CD   1 
ATOM   3345 N NE   . ARG G 1 10 ? -11.167 24.189 -0.441  1.00 13.10 ? 1088 ARG G NE   1 
ATOM   3346 C CZ   . ARG G 1 10 ? -11.079 23.052 -1.117  1.00 13.04 ? 1088 ARG G CZ   1 
ATOM   3347 N NH1  . ARG G 1 10 ? -11.330 21.896 -0.551  1.00 13.31 ? 1088 ARG G NH1  1 
ATOM   3348 N NH2  . ARG G 1 10 ? -10.678 23.076 -2.388  1.00 14.49 ? 1088 ARG G NH2  1 
ATOM   3349 H H    . ARG G 1 10 ? -7.118  27.089 1.642   1.00 16.73 ? 1088 ARG G H    1 
ATOM   3350 H HA   . ARG G 1 10 ? -8.608  25.880 3.560   1.00 21.75 ? 1088 ARG G HA   1 
ATOM   3351 H HB2  . ARG G 1 10 ? -10.048 26.413 1.829   1.00 22.04 ? 1088 ARG G HB2  1 
ATOM   3352 H HB3  . ARG G 1 10 ? -9.100  25.691 0.777   1.00 22.04 ? 1088 ARG G HB3  1 
ATOM   3353 H HG2  . ARG G 1 10 ? -9.665  23.606 1.640   1.00 21.36 ? 1088 ARG G HG2  1 
ATOM   3354 H HG3  . ARG G 1 10 ? -10.517 24.285 2.797   1.00 21.36 ? 1088 ARG G HG3  1 
ATOM   3355 H HD2  . ARG G 1 10 ? -12.035 23.532 1.218   1.00 17.84 ? 1088 ARG G HD2  1 
ATOM   3356 H HD3  . ARG G 1 10 ? -12.016 25.116 1.095   1.00 17.84 ? 1088 ARG G HD3  1 
ATOM   3357 H HE   . ARG G 1 10 ? -11.014 24.918 -0.872  1.00 15.87 ? 1088 ARG G HE   1 
ATOM   3358 H HH11 . ARG G 1 10 ? -11.558 21.863 0.277   1.00 16.12 ? 1088 ARG G HH11 1 
ATOM   3359 H HH12 . ARG G 1 10 ? -11.267 21.170 -1.009  1.00 16.12 ? 1088 ARG G HH12 1 
ATOM   3360 H HH21 . ARG G 1 10 ? -10.478 23.825 -2.761  1.00 17.54 ? 1088 ARG G HH21 1 
ATOM   3361 H HH22 . ARG G 1 10 ? -10.618 22.344 -2.834  1.00 17.54 ? 1088 ARG G HH22 1 
ATOM   3362 N N    . ARG G 1 11 ? -6.491  24.455 1.629   1.00 14.91 ? 1089 ARG G N    1 
ATOM   3363 C CA   . ARG G 1 11 ? -5.682  23.258 1.467   1.00 15.22 ? 1089 ARG G CA   1 
ATOM   3364 C C    . ARG G 1 11 ? -4.227  23.667 1.575   1.00 16.87 ? 1089 ARG G C    1 
ATOM   3365 O O    . ARG G 1 11 ? -3.816  24.666 0.976   1.00 16.92 ? 1089 ARG G O    1 
ATOM   3366 C CB   . ARG G 1 11 ? -5.939  22.551 0.135   1.00 13.66 ? 1089 ARG G CB   1 
ATOM   3367 C CG   . ARG G 1 11 ? -7.362  22.187 -0.086  1.00 18.59 ? 1089 ARG G CG   1 
ATOM   3368 C CD   . ARG G 1 11 ? -7.590  21.580 -1.454  1.00 17.75 ? 1089 ARG G CD   1 
ATOM   3369 N NE   . ARG G 1 11 ? -7.032  20.245 -1.621  1.00 13.02 ? 1089 ARG G NE   1 
ATOM   3370 C CZ   . ARG G 1 11 ? -6.072  19.946 -2.484  1.00 17.41 ? 1089 ARG G CZ   1 
ATOM   3371 N NH1  . ARG G 1 11 ? -5.497  20.878 -3.219  1.00 20.67 ? 1089 ARG G NH1  1 
ATOM   3372 N NH2  . ARG G 1 11 ? -5.708  18.676 -2.639  1.00 22.85 ? 1089 ARG G NH2  1 
ATOM   3373 H H    . ARG G 1 11 ? -6.318  25.075 1.058   1.00 18.03 ? 1089 ARG G H    1 
ATOM   3374 H HA   . ARG G 1 11 ? -5.898  22.621 2.166   1.00 18.41 ? 1089 ARG G HA   1 
ATOM   3375 H HB2  . ARG G 1 11 ? -5.669  23.140 -0.587  1.00 16.54 ? 1089 ARG G HB2  1 
ATOM   3376 H HB3  . ARG G 1 11 ? -5.417  21.734 0.109   1.00 16.54 ? 1089 ARG G HB3  1 
ATOM   3377 H HG2  . ARG G 1 11 ? -7.632  21.538 0.582   1.00 22.45 ? 1089 ARG G HG2  1 
ATOM   3378 H HG3  . ARG G 1 11 ? -7.910  22.985 -0.014  1.00 22.45 ? 1089 ARG G HG3  1 
ATOM   3379 H HD2  . ARG G 1 11 ? -8.545  21.520 -1.611  1.00 21.45 ? 1089 ARG G HD2  1 
ATOM   3380 H HD3  . ARG G 1 11 ? -7.180  22.154 -2.120  1.00 21.45 ? 1089 ARG G HD3  1 
ATOM   3381 H HE   . ARG G 1 11 ? -7.345  19.612 -1.130  1.00 15.76 ? 1089 ARG G HE   1 
ATOM   3382 H HH11 . ARG G 1 11 ? -5.745  21.698 -3.144  1.00 24.95 ? 1089 ARG G HH11 1 
ATOM   3383 H HH12 . ARG G 1 11 ? -4.876  20.665 -3.774  1.00 24.95 ? 1089 ARG G HH12 1 
ATOM   3384 H HH21 . ARG G 1 11 ? -6.096  18.059 -2.182  1.00 27.56 ? 1089 ARG G HH21 1 
ATOM   3385 H HH22 . ARG G 1 11 ? -5.086  18.472 -3.197  1.00 27.56 ? 1089 ARG G HH22 1 
ATOM   3386 N N    . VAL G 1 12 ? -3.463  22.916 2.370   1.00 14.31 ? 1090 VAL G N    1 
ATOM   3387 C CA   . VAL G 1 12 ? -2.026  23.121 2.490   1.00 12.67 ? 1090 VAL G CA   1 
ATOM   3388 C C    . VAL G 1 12 ? -1.351  21.772 2.284   1.00 10.56 ? 1090 VAL G C    1 
ATOM   3389 O O    . VAL G 1 12 ? -1.983  20.713 2.365   1.00 8.36  ? 1090 VAL G O    1 
ATOM   3390 C CB   . VAL G 1 12 ? -1.619  23.773 3.828   1.00 6.99  ? 1090 VAL G CB   1 
ATOM   3391 C CG1  . VAL G 1 12 ? -2.218  25.140 3.911   1.00 8.62  ? 1090 VAL G CG1  1 
ATOM   3392 C CG2  . VAL G 1 12 ? -2.037  22.903 5.004   1.00 12.08 ? 1090 VAL G CG2  1 
ATOM   3393 H H    . VAL G 1 12 ? -3.763  22.274 2.857   1.00 17.32 ? 1090 VAL G H    1 
ATOM   3394 H HA   . VAL G 1 12 ? -1.718  23.721 1.794   1.00 15.35 ? 1090 VAL G HA   1 
ATOM   3395 H HB   . VAL G 1 12 ? -0.654  23.859 3.874   1.00 8.54  ? 1090 VAL G HB   1 
ATOM   3396 H HG11 . VAL G 1 12 ? -1.811  25.618 4.650   1.00 10.50 ? 1090 VAL G HG11 1 
ATOM   3397 H HG12 . VAL G 1 12 ? -2.049  25.609 3.079   1.00 10.50 ? 1090 VAL G HG12 1 
ATOM   3398 H HG13 . VAL G 1 12 ? -3.173  25.057 4.057   1.00 10.50 ? 1090 VAL G HG13 1 
ATOM   3399 H HG21 . VAL G 1 12 ? -1.875  23.387 5.829   1.00 14.64 ? 1090 VAL G HG21 1 
ATOM   3400 H HG22 . VAL G 1 12 ? -2.981  22.695 4.923   1.00 14.64 ? 1090 VAL G HG22 1 
ATOM   3401 H HG23 . VAL G 1 12 ? -1.516  22.085 4.992   1.00 14.64 ? 1090 VAL G HG23 1 
ATOM   3402 N N    . LYS G 1 13 ? -0.065  21.832 1.911   1.00 12.05 ? 1091 LYS G N    1 
ATOM   3403 C CA   . LYS G 1 13 ? 0.761   20.646 1.731   1.00 10.92 ? 1091 LYS G CA   1 
ATOM   3404 C C    . LYS G 1 13 ? 1.929   20.716 2.704   1.00 8.73  ? 1091 LYS G C    1 
ATOM   3405 O O    . LYS G 1 13 ? 2.614   21.746 2.788   1.00 9.92  ? 1091 LYS G O    1 
ATOM   3406 C CB   . LYS G 1 13 ? 1.286   20.504 0.298   1.00 15.23 ? 1091 LYS G CB   1 
ATOM   3407 C CG   . LYS G 1 13 ? 1.800   19.077 0.013   1.00 15.85 ? 1091 LYS G CG   1 
ATOM   3408 C CD   . LYS G 1 13 ? 1.777   18.755 -1.473  1.00 26.87 ? 1091 LYS G CD   1 
ATOM   3409 C CE   . LYS G 1 13 ? 2.721   19.674 -2.218  1.00 35.74 ? 1091 LYS G CE   1 
ATOM   3410 N NZ   . LYS G 1 13 ? 2.393   19.870 -3.666  1.00 47.67 ? 1091 LYS G NZ   1 
ATOM   3411 H H    . LYS G 1 13 ? 0.354   22.567 1.754   1.00 14.61 ? 1091 LYS G H    1 
ATOM   3412 H HA   . LYS G 1 13 ? 0.224   19.860 1.921   1.00 13.25 ? 1091 LYS G HA   1 
ATOM   3413 H HB2  . LYS G 1 13 ? 0.570   20.699 -0.325  1.00 18.42 ? 1091 LYS G HB2  1 
ATOM   3414 H HB3  . LYS G 1 13 ? 2.021   21.123 0.165   1.00 18.42 ? 1091 LYS G HB3  1 
ATOM   3415 H HG2  . LYS G 1 13 ? 2.715   18.997 0.327   1.00 19.17 ? 1091 LYS G HG2  1 
ATOM   3416 H HG3  . LYS G 1 13 ? 1.235   18.435 0.471   1.00 19.17 ? 1091 LYS G HG3  1 
ATOM   3417 H HD2  . LYS G 1 13 ? 2.060   17.838 -1.613  1.00 32.39 ? 1091 LYS G HD2  1 
ATOM   3418 H HD3  . LYS G 1 13 ? 0.881   18.883 -1.821  1.00 32.39 ? 1091 LYS G HD3  1 
ATOM   3419 H HE2  . LYS G 1 13 ? 2.702   20.546 -1.795  1.00 43.04 ? 1091 LYS G HE2  1 
ATOM   3420 H HE3  . LYS G 1 13 ? 3.616   19.302 -2.171  1.00 43.04 ? 1091 LYS G HE3  1 
ATOM   3421 H HZ1  . LYS G 1 13 ? 1.654   20.359 -3.747  1.00 57.35 ? 1091 LYS G HZ1  1 
ATOM   3422 H HZ2  . LYS G 1 13 ? 3.063   20.289 -4.076  1.00 57.35 ? 1091 LYS G HZ2  1 
ATOM   3423 H HZ3  . LYS G 1 13 ? 2.262   19.082 -4.058  1.00 57.35 ? 1091 LYS G HZ3  1 
ATOM   3424 N N    . THR G 1 14 ? 2.144   19.629 3.440   1.00 7.85  ? 1092 THR G N    1 
ATOM   3425 C CA   . THR G 1 14 ? 3.186   19.620 4.453   1.00 7.25  ? 1092 THR G CA   1 
ATOM   3426 C C    . THR G 1 14 ? 4.545   19.486 3.789   1.00 9.84  ? 1092 THR G C    1 
ATOM   3427 O O    . THR G 1 14 ? 4.718   18.723 2.838   1.00 6.77  ? 1092 THR G O    1 
ATOM   3428 C CB   . THR G 1 14 ? 2.994   18.496 5.452   1.00 5.19  ? 1092 THR G CB   1 
ATOM   3429 O OG1  . THR G 1 14 ? 3.043   17.230 4.783   1.00 7.52  ? 1092 THR G OG1  1 
ATOM   3430 C CG2  . THR G 1 14 ? 1.627   18.680 6.221   1.00 8.03  ? 1092 THR G CG2  1 
ATOM   3431 H H    . THR G 1 14 ? 1.703   18.894 3.370   1.00 9.56  ? 1092 THR G H    1 
ATOM   3432 H HA   . THR G 1 14 ? 3.146   20.453 4.948   1.00 8.85  ? 1092 THR G HA   1 
ATOM   3433 H HB   . THR G 1 14 ? 3.706   18.512 6.110   1.00 6.38  ? 1092 THR G HB   1 
ATOM   3434 H HG1  . THR G 1 14 ? 3.100   16.609 5.346   1.00 9.17  ? 1092 THR G HG1  1 
ATOM   3435 H HG21 . THR G 1 14 ? 1.377   17.849 6.655   1.00 9.78  ? 1092 THR G HG21 1 
ATOM   3436 H HG22 . THR G 1 14 ? 1.716   19.372 6.895   1.00 9.78  ? 1092 THR G HG22 1 
ATOM   3437 H HG23 . THR G 1 14 ? 0.928   18.934 5.599   1.00 9.78  ? 1092 THR G HG23 1 
ATOM   3438 N N    . ILE G 1 15 ? 5.510   20.209 4.328   1.00 10.59 ? 1093 ILE G N    1 
ATOM   3439 C CA   . ILE G 1 15 ? 6.855   20.231 3.765   1.00 13.96 ? 1093 ILE G CA   1 
ATOM   3440 C C    . ILE G 1 15 ? 7.890   19.667 4.723   1.00 15.13 ? 1093 ILE G C    1 
ATOM   3441 O O    . ILE G 1 15 ? 9.032   19.423 4.294   1.00 13.88 ? 1093 ILE G O    1 
ATOM   3442 C CB   . ILE G 1 15 ? 7.241   21.651 3.317   1.00 12.16 ? 1093 ILE G CB   1 
ATOM   3443 C CG1  . ILE G 1 15 ? 7.136   22.626 4.478   1.00 17.20 ? 1093 ILE G CG1  1 
ATOM   3444 C CG2  . ILE G 1 15 ? 6.286   22.166 2.188   1.00 10.76 ? 1093 ILE G CG2  1 
ATOM   3445 C CD1  . ILE G 1 15 ? 7.753   24.006 4.140   1.00 22.44 ? 1093 ILE G CD1  1 
ATOM   3446 H H    . ILE G 1 15 ? 5.413   20.702 5.026   1.00 12.85 ? 1093 ILE G H    1 
ATOM   3447 H HA   . ILE G 1 15 ? 6.876   19.671 2.973   1.00 16.89 ? 1093 ILE G HA   1 
ATOM   3448 H HB   . ILE G 1 15 ? 8.154   21.602 2.990   1.00 14.74 ? 1093 ILE G HB   1 
ATOM   3449 H HG12 . ILE G 1 15 ? 6.200   22.758 4.698   1.00 20.79 ? 1093 ILE G HG12 1 
ATOM   3450 H HG13 . ILE G 1 15 ? 7.608   22.262 5.243   1.00 20.79 ? 1093 ILE G HG13 1 
ATOM   3451 H HG21 . ILE G 1 15 ? 6.651   22.983 1.814   1.00 13.06 ? 1093 ILE G HG21 1 
ATOM   3452 H HG22 . ILE G 1 15 ? 6.218   21.488 1.498   1.00 13.06 ? 1093 ILE G HG22 1 
ATOM   3453 H HG23 . ILE G 1 15 ? 5.411   22.338 2.569   1.00 13.06 ? 1093 ILE G HG23 1 
ATOM   3454 H HD11 . ILE G 1 15 ? 7.810   24.534 4.952   1.00 27.07 ? 1093 ILE G HD11 1 
ATOM   3455 H HD12 . ILE G 1 15 ? 8.639   23.874 3.769   1.00 27.07 ? 1093 ILE G HD12 1 
ATOM   3456 H HD13 . ILE G 1 15 ? 7.187   24.455 3.493   1.00 27.07 ? 1093 ILE G HD13 1 
ATOM   3457 N N    . TYR G 1 16 ? 7.509   19.381 5.971   1.00 16.13 ? 1094 TYR G N    1 
ATOM   3458 C CA   . TYR G 1 16 ? 8.342   18.678 6.928   1.00 12.30 ? 1094 TYR G CA   1 
ATOM   3459 C C    . TYR G 1 16 ? 7.485   17.633 7.610   1.00 14.88 ? 1094 TYR G C    1 
ATOM   3460 O O    . TYR G 1 16 ? 6.249   17.691 7.577   1.00 12.99 ? 1094 TYR G O    1 
ATOM   3461 C CB   . TYR G 1 16 ? 8.920   19.615 7.985   1.00 17.36 ? 1094 TYR G CB   1 
ATOM   3462 C CG   . TYR G 1 16 ? 9.818   20.662 7.398   1.00 12.90 ? 1094 TYR G CG   1 
ATOM   3463 C CD1  . TYR G 1 16 ? 11.030  20.314 6.833   1.00 15.69 ? 1094 TYR G CD1  1 
ATOM   3464 C CD2  . TYR G 1 16 ? 9.446   21.988 7.381   1.00 18.21 ? 1094 TYR G CD2  1 
ATOM   3465 C CE1  . TYR G 1 16 ? 11.863  21.265 6.263   1.00 16.88 ? 1094 TYR G CE1  1 
ATOM   3466 C CE2  . TYR G 1 16 ? 10.257  22.944 6.825   1.00 18.38 ? 1094 TYR G CE2  1 
ATOM   3467 C CZ   . TYR G 1 16 ? 11.469  22.574 6.271   1.00 17.19 ? 1094 TYR G CZ   1 
ATOM   3468 O OH   . TYR G 1 16 ? 12.267  23.531 5.719   1.00 27.28 ? 1094 TYR G OH   1 
ATOM   3469 H H    . TYR G 1 16 ? 6.741   19.595 6.293   1.00 19.50 ? 1094 TYR G H    1 
ATOM   3470 H HA   . TYR G 1 16 ? 9.081   18.253 6.464   1.00 14.91 ? 1094 TYR G HA   1 
ATOM   3471 H HB2  . TYR G 1 16 ? 8.191   20.065 8.440   1.00 20.98 ? 1094 TYR G HB2  1 
ATOM   3472 H HB3  . TYR G 1 16 ? 9.437   19.096 8.619   1.00 20.98 ? 1094 TYR G HB3  1 
ATOM   3473 H HD1  . TYR G 1 16 ? 11.294  19.422 6.835   1.00 18.97 ? 1094 TYR G HD1  1 
ATOM   3474 H HD2  . TYR G 1 16 ? 8.632   22.239 7.754   1.00 21.99 ? 1094 TYR G HD2  1 
ATOM   3475 H HE1  . TYR G 1 16 ? 12.674  21.017 5.882   1.00 20.40 ? 1094 TYR G HE1  1 
ATOM   3476 H HE2  . TYR G 1 16 ? 9.993   23.836 6.820   1.00 22.20 ? 1094 TYR G HE2  1 
ATOM   3477 H HH   . TYR G 1 16 ? 12.947  23.176 5.376   1.00 32.88 ? 1094 TYR G HH   1 
ATOM   3478 N N    . ASP G 1 17 ? 8.164   16.657 8.208   1.00 12.18 ? 1095 ASP G N    1 
ATOM   3479 C CA   . ASP G 1 17 ? 7.552   15.756 9.183   1.00 15.89 ? 1095 ASP G CA   1 
ATOM   3480 C C    . ASP G 1 17 ? 7.224   16.494 10.480  1.00 11.33 ? 1095 ASP G C    1 
ATOM   3481 O O    . ASP G 1 17 ? 7.844   17.501 10.818  1.00 11.55 ? 1095 ASP G O    1 
ATOM   3482 C CB   . ASP G 1 17 ? 8.494   14.595 9.482   1.00 11.95 ? 1095 ASP G CB   1 
ATOM   3483 C CG   . ASP G 1 17 ? 8.619   13.637 8.335   1.00 16.03 ? 1095 ASP G CG   1 
ATOM   3484 O OD1  . ASP G 1 17 ? 8.091   13.884 7.209   1.00 9.99  ? 1095 ASP G OD1  1 
ATOM   3485 O OD2  . ASP G 1 17 ? 9.260   12.595 8.562   1.00 16.09 ? 1095 ASP G OD2  1 
ATOM   3486 H H    . ASP G 1 17 ? 8.996   16.492 8.066   1.00 14.77 ? 1095 ASP G H    1 
ATOM   3487 H HA   . ASP G 1 17 ? 6.726   15.404 8.818   1.00 19.21 ? 1095 ASP G HA   1 
ATOM   3488 H HB2  . ASP G 1 17 ? 9.377   14.946 9.677   1.00 14.48 ? 1095 ASP G HB2  1 
ATOM   3489 H HB3  . ASP G 1 17 ? 8.156   14.103 10.247  1.00 14.48 ? 1095 ASP G HB3  1 
ATOM   3490 N N    . CYS G 1 18 ? 6.227   15.986 11.212  1.00 12.94 ? 1096 CYS G N    1 
ATOM   3491 C CA   . CYS G 1 18 ? 5.811   16.628 12.460  1.00 14.44 ? 1096 CYS G CA   1 
ATOM   3492 C C    . CYS G 1 18 ? 5.159   15.597 13.381  1.00 16.49 ? 1096 CYS G C    1 
ATOM   3493 O O    . CYS G 1 18 ? 4.162   14.969 13.013  1.00 15.25 ? 1096 CYS G O    1 
ATOM   3494 C CB   . CYS G 1 18 ? 4.869   17.790 12.179  1.00 14.41 ? 1096 CYS G CB   1 
ATOM   3495 S SG   . CYS G 1 18 ? 4.430   18.761 13.656  1.00 14.99 ? 1096 CYS G SG   1 
ATOM   3496 H H    . CYS G 1 18 ? 5.783   15.278 11.009  1.00 15.68 ? 1096 CYS G H    1 
ATOM   3497 H HA   . CYS G 1 18 ? 6.595   16.966 12.920  1.00 17.48 ? 1096 CYS G HA   1 
ATOM   3498 H HB2  . CYS G 1 18 ? 5.296   18.390 11.548  1.00 17.44 ? 1096 CYS G HB2  1 
ATOM   3499 H HB3  . CYS G 1 18 ? 4.048   17.439 11.801  1.00 17.44 ? 1096 CYS G HB3  1 
ATOM   3500 H HG   . CYS G 1 18 ? 3.837   18.056 14.425  1.00 18.13 ? 1096 CYS G HG   1 
ATOM   3501 N N    . GLN G 1 19 ? 5.726   15.440 14.587  1.00 13.86 ? 1097 GLN G N    1 
ATOM   3502 C CA   . GLN G 1 19 ? 5.212   14.558 15.633  1.00 16.45 ? 1097 GLN G CA   1 
ATOM   3503 C C    . GLN G 1 19 ? 4.566   15.437 16.692  1.00 15.05 ? 1097 GLN G C    1 
ATOM   3504 O O    . GLN G 1 19 ? 5.174   16.414 17.156  1.00 11.17 ? 1097 GLN G O    1 
ATOM   3505 C CB   . GLN G 1 19 ? 6.395   13.723 16.133  1.00 21.83 ? 1097 GLN G CB   1 
ATOM   3506 C CG   . GLN G 1 19 ? 6.189   12.672 17.098  1.00 33.34 ? 1097 GLN G CG   1 
ATOM   3507 C CD   . GLN G 1 19 ? 4.913   12.067 16.980  1.00 50.18 ? 1097 GLN G CD   1 
ATOM   3508 O OE1  . GLN G 1 19 ? 4.021   12.361 17.783  1.00 54.72 ? 1097 GLN G OE1  1 
ATOM   3509 N NE2  . GLN G 1 19 ? 4.839   11.049 16.061  1.00 51.38 ? 1097 GLN G NE2  1 
ATOM   3510 H H    . GLN G 1 19 ? 6.439   15.855 14.828  1.00 16.78 ? 1097 GLN G H    1 
ATOM   3511 H HA   . GLN G 1 19 ? 4.521   13.940 15.347  1.00 19.89 ? 1097 GLN G HA   1 
ATOM   3512 H HB2  . GLN G 1 19 ? 6.794   13.300 15.357  1.00 26.34 ? 1097 GLN G HB2  1 
ATOM   3513 H HB3  . GLN G 1 19 ? 7.027   14.338 16.537  1.00 26.34 ? 1097 GLN G HB3  1 
ATOM   3514 H HG2  . GLN G 1 19 ? 6.861   11.985 16.966  1.00 40.16 ? 1097 GLN G HG2  1 
ATOM   3515 H HG3  . GLN G 1 19 ? 6.264   13.043 17.991  1.00 40.16 ? 1097 GLN G HG3  1 
ATOM   3516 H HE21 . GLN G 1 19 ? 5.537   10.825 15.610  1.00 61.80 ? 1097 GLN G HE21 1 
ATOM   3517 H HE22 . GLN G 1 19 ? 4.095   10.636 15.936  1.00 61.80 ? 1097 GLN G HE22 1 
ATOM   3518 N N    . ALA G 1 20 ? 3.298   15.149 16.998  1.00 11.85 ? 1098 ALA G N    1 
ATOM   3519 C CA   . ALA G 1 20 ? 2.591   15.950 17.976  1.00 9.79  ? 1098 ALA G CA   1 
ATOM   3520 C C    . ALA G 1 20 ? 3.303   15.911 19.319  1.00 9.93  ? 1098 ALA G C    1 
ATOM   3521 O O    . ALA G 1 20 ? 3.740   14.859 19.780  1.00 7.62  ? 1098 ALA G O    1 
ATOM   3522 C CB   . ALA G 1 20 ? 1.175   15.442 18.141  1.00 14.03 ? 1098 ALA G CB   1 
ATOM   3523 H H    . ALA G 1 20 ? 2.840   14.506 16.656  1.00 14.37 ? 1098 ALA G H    1 
ATOM   3524 H HA   . ALA G 1 20 ? 2.561   16.869 17.669  1.00 11.89 ? 1098 ALA G HA   1 
ATOM   3525 H HB1  . ALA G 1 20 ? 0.742   15.939 18.852  1.00 16.98 ? 1098 ALA G HB1  1 
ATOM   3526 H HB2  . ALA G 1 20 ? 0.695   15.570 17.308  1.00 16.98 ? 1098 ALA G HB2  1 
ATOM   3527 H HB3  . ALA G 1 20 ? 1.202   14.499 18.365  1.00 16.98 ? 1098 ALA G HB3  1 
ATOM   3528 N N    . ASP G 1 21 ? 3.367   17.069 19.953  1.00 8.18  ? 1099 ASP G N    1 
ATOM   3529 C CA   . ASP G 1 21 ? 3.854   17.200 21.307  1.00 11.05 ? 1099 ASP G CA   1 
ATOM   3530 C C    . ASP G 1 21 ? 2.742   17.227 22.338  1.00 16.11 ? 1099 ASP G C    1 
ATOM   3531 O O    . ASP G 1 21 ? 2.997   16.927 23.505  1.00 12.00 ? 1099 ASP G O    1 
ATOM   3532 C CB   . ASP G 1 21 ? 4.687   18.474 21.419  1.00 16.55 ? 1099 ASP G CB   1 
ATOM   3533 C CG   . ASP G 1 21 ? 5.826   18.495 20.390  1.00 20.41 ? 1099 ASP G CG   1 
ATOM   3534 O OD1  . ASP G 1 21 ? 6.571   17.489 20.337  1.00 16.90 ? 1099 ASP G OD1  1 
ATOM   3535 O OD2  . ASP G 1 21 ? 5.948   19.493 19.641  1.00 23.60 ? 1099 ASP G OD2  1 
ATOM   3536 H H    . ASP G 1 21 ? 3.126   17.817 19.606  1.00 9.96  ? 1099 ASP G H    1 
ATOM   3537 H HA   . ASP G 1 21 ? 4.425   16.446 21.524  1.00 13.41 ? 1099 ASP G HA   1 
ATOM   3538 H HB2  . ASP G 1 21 ? 4.119   19.244 21.260  1.00 20.00 ? 1099 ASP G HB2  1 
ATOM   3539 H HB3  . ASP G 1 21 ? 5.076   18.526 22.306  1.00 20.00 ? 1099 ASP G HB3  1 
ATOM   3540 N N    . ASN G 1 22 ? 1.529   17.526 21.916  1.00 11.63 ? 1100 ASN G N    1 
ATOM   3541 C CA   . ASN G 1 22 ? 0.380   17.653 22.792  1.00 12.68 ? 1100 ASN G CA   1 
ATOM   3542 C C    . ASN G 1 22 ? -0.780  16.916 22.160  1.00 8.48  ? 1100 ASN G C    1 
ATOM   3543 O O    . ASN G 1 22 ? -0.767  16.604 20.977  1.00 7.41  ? 1100 ASN G O    1 
ATOM   3544 C CB   . ASN G 1 22 ? 0.039   19.111 23.018  1.00 11.60 ? 1100 ASN G CB   1 
ATOM   3545 C CG   . ASN G 1 22 ? 1.173   19.862 23.697  1.00 19.54 ? 1100 ASN G CG   1 
ATOM   3546 O OD1  . ASN G 1 22 ? 1.434   19.664 24.886  1.00 27.11 ? 1100 ASN G OD1  1 
ATOM   3547 N ND2  . ASN G 1 22 ? 1.858   20.714 22.945  1.00 14.83 ? 1100 ASN G ND2  1 
ATOM   3548 H H    . ASN G 1 22 ? 1.337   17.668 21.090  1.00 14.11 ? 1100 ASN G H    1 
ATOM   3549 H HA   . ASN G 1 22 ? 0.554   17.254 23.659  1.00 15.37 ? 1100 ASN G HA   1 
ATOM   3550 H HB2  . ASN G 1 22 ? -0.136  19.534 22.163  1.00 14.06 ? 1100 ASN G HB2  1 
ATOM   3551 H HB3  . ASN G 1 22 ? -0.747  19.171 23.585  1.00 14.06 ? 1100 ASN G HB3  1 
ATOM   3552 H HD21 . ASN G 1 22 ? 2.509   21.161 23.285  1.00 17.94 ? 1100 ASN G HD21 1 
ATOM   3553 H HD22 . ASN G 1 22 ? 1.651   20.818 22.117  1.00 17.94 ? 1100 ASN G HD22 1 
ATOM   3554 N N    . ASP G 1 23 ? -1.772  16.605 22.976  1.00 10.18 ? 1101 ASP G N    1 
ATOM   3555 C CA   . ASP G 1 23 ? -2.819  15.712 22.541  1.00 8.90  ? 1101 ASP G CA   1 
ATOM   3556 C C    . ASP G 1 23 ? -3.827  16.390 21.618  1.00 6.95  ? 1101 ASP G C    1 
ATOM   3557 O O    . ASP G 1 23 ? -4.739  15.718 21.162  1.00 7.89  ? 1101 ASP G O    1 
ATOM   3558 C CB   . ASP G 1 23 ? -3.527  15.112 23.773  1.00 8.61  ? 1101 ASP G CB   1 
ATOM   3559 C CG   . ASP G 1 23 ? -2.897  13.784 24.250  1.00 9.03  ? 1101 ASP G CG   1 
ATOM   3560 O OD1  . ASP G 1 23 ? -2.290  13.106 23.401  1.00 10.98 ? 1101 ASP G OD1  1 
ATOM   3561 O OD2  . ASP G 1 23 ? -3.025  13.415 25.458  1.00 8.61  ? 1101 ASP G OD2  1 
ATOM   3562 H H    . ASP G 1 23 ? -1.857  16.898 23.780  1.00 12.37 ? 1101 ASP G H    1 
ATOM   3563 H HA   . ASP G 1 23 ? -2.430  14.976 22.043  1.00 10.82 ? 1101 ASP G HA   1 
ATOM   3564 H HB2  . ASP G 1 23 ? -3.475  15.746 24.505  1.00 10.48 ? 1101 ASP G HB2  1 
ATOM   3565 H HB3  . ASP G 1 23 ? -4.454  14.938 23.549  1.00 10.48 ? 1101 ASP G HB3  1 
ATOM   3566 N N    . ASP G 1 24 ? -3.682  17.678 21.312  1.00 8.26  ? 1102 ASP G N    1 
ATOM   3567 C CA   . ASP G 1 24 ? -4.517  18.314 20.299  1.00 10.59 ? 1102 ASP G CA   1 
ATOM   3568 C C    . ASP G 1 24 ? -3.759  18.600 18.997  1.00 8.85  ? 1102 ASP G C    1 
ATOM   3569 O O    . ASP G 1 24 ? -4.309  19.231 18.095  1.00 8.81  ? 1102 ASP G O    1 
ATOM   3570 C CB   . ASP G 1 24 ? -5.153  19.586 20.857  1.00 7.53  ? 1102 ASP G CB   1 
ATOM   3571 C CG   . ASP G 1 24 ? -4.164  20.596 21.342  1.00 12.34 ? 1102 ASP G CG   1 
ATOM   3572 O OD1  . ASP G 1 24 ? -2.993  20.246 21.526  1.00 12.74 ? 1102 ASP G OD1  1 
ATOM   3573 O OD2  . ASP G 1 24 ? -4.563  21.765 21.566  1.00 15.01 ? 1102 ASP G OD2  1 
ATOM   3574 H H    . ASP G 1 24 ? -3.108  18.202 21.679  1.00 10.06 ? 1102 ASP G H    1 
ATOM   3575 H HA   . ASP G 1 24 ? -5.241  17.709 20.073  1.00 12.86 ? 1102 ASP G HA   1 
ATOM   3576 H HB2  . ASP G 1 24 ? -5.681  20.003 20.158  1.00 9.18  ? 1102 ASP G HB2  1 
ATOM   3577 H HB3  . ASP G 1 24 ? -5.723  19.348 21.605  1.00 9.18  ? 1102 ASP G HB3  1 
ATOM   3578 N N    . GLU G 1 25 ? -2.535  18.112 18.862  1.00 11.25 ? 1103 GLU G N    1 
ATOM   3579 C CA   . GLU G 1 25 ? -1.695  18.432 17.722  1.00 4.89  ? 1103 GLU G CA   1 
ATOM   3580 C C    . GLU G 1 25 ? -1.718  17.314 16.708  1.00 6.27  ? 1103 GLU G C    1 
ATOM   3581 O O    . GLU G 1 25 ? -1.723  16.127 17.050  1.00 11.02 ? 1103 GLU G O    1 
ATOM   3582 C CB   . GLU G 1 25 ? -0.253  18.711 18.154  1.00 6.82  ? 1103 GLU G CB   1 
ATOM   3583 C CG   . GLU G 1 25 ? -0.087  20.055 18.806  1.00 9.25  ? 1103 GLU G CG   1 
ATOM   3584 C CD   . GLU G 1 25 ? 1.320   20.249 19.385  1.00 17.04 ? 1103 GLU G CD   1 
ATOM   3585 O OE1  . GLU G 1 25 ? 2.215   19.429 19.032  1.00 14.91 ? 1103 GLU G OE1  1 
ATOM   3586 O OE2  . GLU G 1 25 ? 1.510   21.228 20.164  1.00 14.44 ? 1103 GLU G OE2  1 
ATOM   3587 H H    . GLU G 1 25 ? -2.163  17.584 19.430  1.00 13.65 ? 1103 GLU G H    1 
ATOM   3588 H HA   . GLU G 1 25 ? -2.042  19.232 17.297  1.00 6.01  ? 1103 GLU G HA   1 
ATOM   3589 H HB2  . GLU G 1 25 ? 0.023   18.033 18.790  1.00 8.34  ? 1103 GLU G HB2  1 
ATOM   3590 H HB3  . GLU G 1 25 ? 0.321   18.685 17.372  1.00 8.34  ? 1103 GLU G HB3  1 
ATOM   3591 H HG2  . GLU G 1 25 ? -0.240  20.750 18.147  1.00 11.25 ? 1103 GLU G HG2  1 
ATOM   3592 H HG3  . GLU G 1 25 ? -0.726  20.138 19.530  1.00 11.25 ? 1103 GLU G HG3  1 
ATOM   3593 N N    . LEU G 1 26 ? -1.636  17.715 15.444  1.00 7.31  ? 1104 LEU G N    1 
ATOM   3594 C CA   . LEU G 1 26 ? -1.598  16.779 14.337  1.00 4.97  ? 1104 LEU G CA   1 
ATOM   3595 C C    . LEU G 1 26 ? -0.179  16.275 14.087  1.00 5.97  ? 1104 LEU G C    1 
ATOM   3596 O O    . LEU G 1 26 ? 0.794   17.043 14.097  1.00 7.22  ? 1104 LEU G O    1 
ATOM   3597 C CB   . LEU G 1 26 ? -2.160  17.472 13.092  1.00 5.22  ? 1104 LEU G CB   1 
ATOM   3598 C CG   . LEU G 1 26 ? -2.366  16.583 11.866  1.00 10.82 ? 1104 LEU G CG   1 
ATOM   3599 C CD1  . LEU G 1 26 ? -3.382  15.468 12.024  1.00 11.10 ? 1104 LEU G CD1  1 
ATOM   3600 C CD2  . LEU G 1 26 ? -2.693  17.485 10.621  1.00 11.04 ? 1104 LEU G CD2  1 
ATOM   3601 H H    . LEU G 1 26 ? -1.600  18.539 15.201  1.00 8.92  ? 1104 LEU G H    1 
ATOM   3602 H HA   . LEU G 1 26 ? -2.135  15.998 14.542  1.00 6.12  ? 1104 LEU G HA   1 
ATOM   3603 H HB2  . LEU G 1 26 ? -3.023  17.851 13.321  1.00 6.41  ? 1104 LEU G HB2  1 
ATOM   3604 H HB3  . LEU G 1 26 ? -1.546  18.178 12.836  1.00 6.41  ? 1104 LEU G HB3  1 
ATOM   3605 H HG   . LEU G 1 26 ? -1.533  16.105 11.728  1.00 13.14 ? 1104 LEU G HG   1 
ATOM   3606 H HD11 . LEU G 1 26 ? -2.924  14.614 11.977  1.00 13.46 ? 1104 LEU G HD11 1 
ATOM   3607 H HD12 . LEU G 1 26 ? -3.822  15.560 12.884  1.00 13.46 ? 1104 LEU G HD12 1 
ATOM   3608 H HD13 . LEU G 1 26 ? -4.036  15.532 11.310  1.00 13.46 ? 1104 LEU G HD13 1 
ATOM   3609 H HD21 . LEU G 1 26 ? -2.826  16.917 9.846   1.00 13.39 ? 1104 LEU G HD21 1 
ATOM   3610 H HD22 . LEU G 1 26 ? -3.500  17.992 10.802  1.00 13.39 ? 1104 LEU G HD22 1 
ATOM   3611 H HD23 . LEU G 1 26 ? -1.951  18.089 10.465  1.00 13.39 ? 1104 LEU G HD23 1 
ATOM   3612 N N    . THR G 1 27 ? -0.079  14.968 13.891  1.00 9.45  ? 1105 THR G N    1 
ATOM   3613 C CA   . THR G 1 27 ? 1.129   14.269 13.498  1.00 10.49 ? 1105 THR G CA   1 
ATOM   3614 C C    . THR G 1 27 ? 1.035   13.948 12.029  1.00 11.24 ? 1105 THR G C    1 
ATOM   3615 O O    . THR G 1 27 ? 0.012   13.429 11.586  1.00 10.30 ? 1105 THR G O    1 
ATOM   3616 C CB   . THR G 1 27 ? 1.301   12.965 14.283  1.00 14.55 ? 1105 THR G CB   1 
ATOM   3617 O OG1  . THR G 1 27 ? 1.578   13.292 15.636  1.00 12.54 ? 1105 THR G OG1  1 
ATOM   3618 C CG2  . THR G 1 27 ? 2.412   12.145 13.684  1.00 16.35 ? 1105 THR G CG2  1 
ATOM   3619 H H    . THR G 1 27 ? -0.744  14.430 13.987  1.00 11.49 ? 1105 THR G H    1 
ATOM   3620 H HA   . THR G 1 27 ? 1.899   14.833 13.669  1.00 12.74 ? 1105 THR G HA   1 
ATOM   3621 H HB   . THR G 1 27 ? 0.496   12.425 14.247  1.00 17.61 ? 1105 THR G HB   1 
ATOM   3622 H HG1  . THR G 1 27 ? 1.703   12.590 16.081  1.00 15.20 ? 1105 THR G HG1  1 
ATOM   3623 H HG21 . THR G 1 27 ? 2.701   11.467 14.315  1.00 19.76 ? 1105 THR G HG21 1 
ATOM   3624 H HG22 . THR G 1 27 ? 2.104   11.710 12.873  1.00 19.76 ? 1105 THR G HG22 1 
ATOM   3625 H HG23 . THR G 1 27 ? 3.166   12.716 13.468  1.00 19.76 ? 1105 THR G HG23 1 
ATOM   3626 N N    . PHE G 1 28 ? 2.102   14.238 11.286  1.00 7.27  ? 1106 PHE G N    1 
ATOM   3627 C CA   . PHE G 1 28 ? 2.095   14.008 9.861   1.00 9.14  ? 1106 PHE G CA   1 
ATOM   3628 C C    . PHE G 1 28 ? 3.525   13.845 9.370   1.00 10.58 ? 1106 PHE G C    1 
ATOM   3629 O O    . PHE G 1 28 ? 4.477   14.184 10.059  1.00 9.36  ? 1106 PHE G O    1 
ATOM   3630 C CB   . PHE G 1 28 ? 1.403   15.158 9.125   1.00 6.24  ? 1106 PHE G CB   1 
ATOM   3631 C CG   . PHE G 1 28 ? 1.915   16.532 9.475   1.00 5.37  ? 1106 PHE G CG   1 
ATOM   3632 C CD1  . PHE G 1 28 ? 2.987   17.074 8.807   1.00 8.43  ? 1106 PHE G CD1  1 
ATOM   3633 C CD2  . PHE G 1 28 ? 1.306   17.294 10.432  1.00 6.31  ? 1106 PHE G CD2  1 
ATOM   3634 C CE1  . PHE G 1 28 ? 3.415   18.341 9.083   1.00 7.86  ? 1106 PHE G CE1  1 
ATOM   3635 C CE2  . PHE G 1 28 ? 1.757   18.549 10.739  1.00 8.06  ? 1106 PHE G CE2  1 
ATOM   3636 C CZ   . PHE G 1 28 ? 2.807   19.077 10.069  1.00 12.40 ? 1106 PHE G CZ   1 
ATOM   3637 H H    . PHE G 1 28 ? 2.836   14.568 11.591  1.00 8.87  ? 1106 PHE G H    1 
ATOM   3638 H HA   . PHE G 1 28 ? 1.621   13.183 9.673   1.00 11.12 ? 1106 PHE G HA   1 
ATOM   3639 H HB2  . PHE G 1 28 ? 1.530   15.033 8.172   1.00 7.64  ? 1106 PHE G HB2  1 
ATOM   3640 H HB3  . PHE G 1 28 ? 0.457   15.136 9.339   1.00 7.64  ? 1106 PHE G HB3  1 
ATOM   3641 H HD1  . PHE G 1 28 ? 3.426   16.572 8.159   1.00 10.26 ? 1106 PHE G HD1  1 
ATOM   3642 H HD2  . PHE G 1 28 ? 0.569   16.952 10.885  1.00 7.72  ? 1106 PHE G HD2  1 
ATOM   3643 H HE1  . PHE G 1 28 ? 4.122   18.706 8.602   1.00 9.58  ? 1106 PHE G HE1  1 
ATOM   3644 H HE2  . PHE G 1 28 ? 1.341   19.039 11.411  1.00 9.82  ? 1106 PHE G HE2  1 
ATOM   3645 H HZ   . PHE G 1 28 ? 3.113   19.931 10.273  1.00 15.02 ? 1106 PHE G HZ   1 
ATOM   3646 N N    . ILE G 1 29 ? 3.646   13.329 8.157   1.00 13.37 ? 1107 ILE G N    1 
ATOM   3647 C CA   . ILE G 1 29 ? 4.897   13.319 7.428   1.00 11.29 ? 1107 ILE G CA   1 
ATOM   3648 C C    . ILE G 1 29 ? 4.784   14.374 6.337   1.00 13.79 ? 1107 ILE G C    1 
ATOM   3649 O O    . ILE G 1 29 ? 3.708   14.934 6.063   1.00 7.17  ? 1107 ILE G O    1 
ATOM   3650 C CB   . ILE G 1 29 ? 5.223   11.934 6.826   1.00 9.72  ? 1107 ILE G CB   1 
ATOM   3651 C CG1  . ILE G 1 29 ? 4.108   11.494 5.854   1.00 14.11 ? 1107 ILE G CG1  1 
ATOM   3652 C CG2  . ILE G 1 29 ? 5.437   10.899 7.934   1.00 14.42 ? 1107 ILE G CG2  1 
ATOM   3653 C CD1  . ILE G 1 29 ? 4.433   10.304 5.002   1.00 12.64 ? 1107 ILE G CD1  1 
ATOM   3654 H H    . ILE G 1 29 ? 2.996   12.969 7.723   1.00 16.20 ? 1107 ILE G H    1 
ATOM   3655 H HA   . ILE G 1 29 ? 5.623   13.545 8.029   1.00 13.70 ? 1107 ILE G HA   1 
ATOM   3656 H HB   . ILE G 1 29 ? 6.049   12.004 6.322   1.00 11.81 ? 1107 ILE G HB   1 
ATOM   3657 H HG12 . ILE G 1 29 ? 3.320   11.271 6.373   1.00 17.07 ? 1107 ILE G HG12 1 
ATOM   3658 H HG13 . ILE G 1 29 ? 3.914   12.233 5.256   1.00 17.07 ? 1107 ILE G HG13 1 
ATOM   3659 H HG21 . ILE G 1 29 ? 5.696   10.055 7.533   1.00 17.45 ? 1107 ILE G HG21 1 
ATOM   3660 H HG22 . ILE G 1 29 ? 6.137   11.213 8.528   1.00 17.45 ? 1107 ILE G HG22 1 
ATOM   3661 H HG23 . ILE G 1 29 ? 4.609   10.790 8.428   1.00 17.45 ? 1107 ILE G HG23 1 
ATOM   3662 H HD11 . ILE G 1 29 ? 3.681   10.118 4.420   1.00 15.32 ? 1107 ILE G HD11 1 
ATOM   3663 H HD12 . ILE G 1 29 ? 5.221   10.501 4.472   1.00 15.32 ? 1107 ILE G HD12 1 
ATOM   3664 H HD13 . ILE G 1 29 ? 4.604   9.542  5.577   1.00 15.32 ? 1107 ILE G HD13 1 
ATOM   3665 N N    . GLU G 1 30 ? 5.925   14.649 5.725   1.00 8.78  ? 1108 GLU G N    1 
ATOM   3666 C CA   . GLU G 1 30 ? 6.045   15.506 4.564   1.00 9.28  ? 1108 GLU G CA   1 
ATOM   3667 C C    . GLU G 1 30 ? 5.241   14.953 3.398   1.00 6.05  ? 1108 GLU G C    1 
ATOM   3668 O O    . GLU G 1 30 ? 5.119   13.744 3.221   1.00 6.20  ? 1108 GLU G O    1 
ATOM   3669 C CB   . GLU G 1 30 ? 7.534   15.597 4.179   1.00 11.72 ? 1108 GLU G CB   1 
ATOM   3670 C CG   . GLU G 1 30 ? 7.838   16.619 3.189   1.00 10.70 ? 1108 GLU G CG   1 
ATOM   3671 C CD   . GLU G 1 30 ? 7.671   16.117 1.786   1.00 12.34 ? 1108 GLU G CD   1 
ATOM   3672 O OE1  . GLU G 1 30 ? 7.292   14.953 1.581   1.00 14.38 ? 1108 GLU G OE1  1 
ATOM   3673 O OE2  . GLU G 1 30 ? 7.988   16.879 0.860   1.00 13.94 ? 1108 GLU G OE2  1 
ATOM   3674 H H    . GLU G 1 30 ? 6.685   14.335 5.978   1.00 10.68 ? 1108 GLU G H    1 
ATOM   3675 H HA   . GLU G 1 30 ? 5.704   16.392 4.759   1.00 11.28 ? 1108 GLU G HA   1 
ATOM   3676 H HB2  . GLU G 1 30 ? 8.047   15.800 4.977   1.00 14.22 ? 1108 GLU G HB2  1 
ATOM   3677 H HB3  . GLU G 1 30 ? 7.812   14.743 3.814   1.00 14.22 ? 1108 GLU G HB3  1 
ATOM   3678 H HG2  . GLU G 1 30 ? 7.238   17.371 3.314   1.00 12.98 ? 1108 GLU G HG2  1 
ATOM   3679 H HG3  . GLU G 1 30 ? 8.758   16.906 3.300   1.00 12.98 ? 1108 GLU G HG3  1 
ATOM   3680 N N    . GLY G 1 31 ? 4.758   15.861 2.545   1.00 5.54  ? 1109 GLY G N    1 
ATOM   3681 C CA   . GLY G 1 31 ? 4.016   15.502 1.366   1.00 8.30  ? 1109 GLY G CA   1 
ATOM   3682 C C    . GLY G 1 31 ? 2.516   15.313 1.541   1.00 8.62  ? 1109 GLY G C    1 
ATOM   3683 O O    . GLY G 1 31 ? 1.854   14.864 0.601   1.00 14.65 ? 1109 GLY G O    1 
ATOM   3684 H H    . GLY G 1 31 ? 4.858   16.710 2.642   1.00 6.80  ? 1109 GLY G H    1 
ATOM   3685 H HA2  . GLY G 1 31 ? 4.144   16.198 0.702   1.00 10.10 ? 1109 GLY G HA2  1 
ATOM   3686 H HA3  . GLY G 1 31 ? 4.374   14.669 1.022   1.00 10.10 ? 1109 GLY G HA3  1 
ATOM   3687 N N    . GLU G 1 32 ? 1.965   15.549 2.720   1.00 11.17 ? 1110 GLU G N    1 
ATOM   3688 C CA   . GLU G 1 32 ? 0.544   15.285 2.944   1.00 10.86 ? 1110 GLU G CA   1 
ATOM   3689 C C    . GLU G 1 32 ? -0.265  16.550 2.792   1.00 7.82  ? 1110 GLU G C    1 
ATOM   3690 O O    . GLU G 1 32 ? 0.191   17.636 3.144   1.00 7.34  ? 1110 GLU G O    1 
ATOM   3691 C CB   . GLU G 1 32 ? 0.286   14.687 4.328   1.00 12.01 ? 1110 GLU G CB   1 
ATOM   3692 C CG   . GLU G 1 32 ? 1.002   13.358 4.591   1.00 9.20  ? 1110 GLU G CG   1 
ATOM   3693 C CD   . GLU G 1 32 ? 0.412   12.634 5.753   1.00 12.80 ? 1110 GLU G CD   1 
ATOM   3694 O OE1  . GLU G 1 32 ? -0.666  12.022 5.556   1.00 19.43 ? 1110 GLU G OE1  1 
ATOM   3695 O OE2  . GLU G 1 32 ? 1.013   12.657 6.856   1.00 12.73 ? 1110 GLU G OE2  1 
ATOM   3696 H H    . GLU G 1 32 ? 2.385   15.859 3.403   1.00 13.55 ? 1110 GLU G H    1 
ATOM   3697 H HA   . GLU G 1 32 ? 0.248   14.643 2.280   1.00 13.18 ? 1110 GLU G HA   1 
ATOM   3698 H HB2  . GLU G 1 32 ? 0.588   15.320 4.999   1.00 14.55 ? 1110 GLU G HB2  1 
ATOM   3699 H HB3  . GLU G 1 32 ? -0.667  14.531 4.424   1.00 14.55 ? 1110 GLU G HB3  1 
ATOM   3700 H HG2  . GLU G 1 32 ? 0.922   12.791 3.808   1.00 11.19 ? 1110 GLU G HG2  1 
ATOM   3701 H HG3  . GLU G 1 32 ? 1.937   13.530 4.782   1.00 11.19 ? 1110 GLU G HG3  1 
ATOM   3702 N N    . VAL G 1 33 ? -1.501  16.384 2.326   1.00 14.38 ? 1111 VAL G N    1 
ATOM   3703 C CA   . VAL G 1 33 ? -2.432  17.493 2.193   1.00 14.44 ? 1111 VAL G CA   1 
ATOM   3704 C C    . VAL G 1 33 ? -3.280  17.559 3.451   1.00 5.48  ? 1111 VAL G C    1 
ATOM   3705 O O    . VAL G 1 33 ? -3.817  16.546 3.904   1.00 5.19  ? 1111 VAL G O    1 
ATOM   3706 C CB   . VAL G 1 33 ? -3.296  17.342 0.927   1.00 16.85 ? 1111 VAL G CB   1 
ATOM   3707 C CG1  . VAL G 1 33 ? -4.325  18.461 0.845   1.00 14.70 ? 1111 VAL G CG1  1 
ATOM   3708 C CG2  . VAL G 1 33 ? -2.385  17.314 -0.306  1.00 16.48 ? 1111 VAL G CG2  1 
ATOM   3709 H H    . VAL G 1 33 ? -1.825  15.627 2.078   1.00 17.41 ? 1111 VAL G H    1 
ATOM   3710 H HA   . VAL G 1 33 ? -1.941  18.326 2.114   1.00 17.48 ? 1111 VAL G HA   1 
ATOM   3711 H HB   . VAL G 1 33 ? -3.791  16.508 0.957   1.00 20.37 ? 1111 VAL G HB   1 
ATOM   3712 H HG11 . VAL G 1 33 ? -4.700  18.481 -0.049  1.00 17.79 ? 1111 VAL G HG11 1 
ATOM   3713 H HG12 . VAL G 1 33 ? -5.026  18.294 1.494   1.00 17.79 ? 1111 VAL G HG12 1 
ATOM   3714 H HG13 . VAL G 1 33 ? -3.889  19.306 1.040   1.00 17.79 ? 1111 VAL G HG13 1 
ATOM   3715 H HG21 . VAL G 1 33 ? -2.934  17.252 -1.103  1.00 19.93 ? 1111 VAL G HG21 1 
ATOM   3716 H HG22 . VAL G 1 33 ? -1.859  18.129 -0.329  1.00 19.93 ? 1111 VAL G HG22 1 
ATOM   3717 H HG23 . VAL G 1 33 ? -1.798  16.544 -0.247  1.00 19.93 ? 1111 VAL G HG23 1 
ATOM   3718 N N    . ILE G 1 34 ? -3.363  18.759 4.014   1.00 7.20  ? 1112 ILE G N    1 
ATOM   3719 C CA   . ILE G 1 34 ? -4.179  19.088 5.164   1.00 10.43 ? 1112 ILE G CA   1 
ATOM   3720 C C    . ILE G 1 34 ? -5.297  20.000 4.697   1.00 9.47  ? 1112 ILE G C    1 
ATOM   3721 O O    . ILE G 1 34 ? -5.047  20.978 3.989   1.00 10.02 ? 1112 ILE G O    1 
ATOM   3722 C CB   . ILE G 1 34 ? -3.365  19.785 6.266   1.00 9.86  ? 1112 ILE G CB   1 
ATOM   3723 C CG1  . ILE G 1 34 ? -2.354  18.796 6.888   1.00 8.63  ? 1112 ILE G CG1  1 
ATOM   3724 C CG2  . ILE G 1 34 ? -4.303  20.391 7.323   1.00 6.76  ? 1112 ILE G CG2  1 
ATOM   3725 C CD1  . ILE G 1 34 ? -1.308  19.500 7.730   1.00 10.08 ? 1112 ILE G CD1  1 
ATOM   3726 H H    . ILE G 1 34 ? -2.924  19.440 3.725   1.00 8.78  ? 1112 ILE G H    1 
ATOM   3727 H HA   . ILE G 1 34 ? -4.554  18.270 5.525   1.00 12.66 ? 1112 ILE G HA   1 
ATOM   3728 H HB   . ILE G 1 34 ? -2.859  20.513 5.874   1.00 11.97 ? 1112 ILE G HB   1 
ATOM   3729 H HG12 . ILE G 1 34 ? -2.829  18.171 7.457   1.00 10.50 ? 1112 ILE G HG12 1 
ATOM   3730 H HG13 . ILE G 1 34 ? -1.898  18.318 6.178   1.00 10.50 ? 1112 ILE G HG13 1 
ATOM   3731 H HG21 . ILE G 1 34 ? -3.795  20.575 8.128   1.00 8.26  ? 1112 ILE G HG21 1 
ATOM   3732 H HG22 . ILE G 1 34 ? -4.681  21.214 6.975   1.00 8.26  ? 1112 ILE G HG22 1 
ATOM   3733 H HG23 . ILE G 1 34 ? -5.012  19.757 7.517   1.00 8.26  ? 1112 ILE G HG23 1 
ATOM   3734 H HD11 . ILE G 1 34 ? -0.605  18.870 7.953   1.00 12.25 ? 1112 ILE G HD11 1 
ATOM   3735 H HD12 . ILE G 1 34 ? -0.939  20.240 7.223   1.00 12.25 ? 1112 ILE G HD12 1 
ATOM   3736 H HD13 . ILE G 1 34 ? -1.726  19.831 8.541   1.00 12.25 ? 1112 ILE G HD13 1 
ATOM   3737 N N    . ILE G 1 35 ? -6.515  19.701 5.133   1.00 9.33  ? 1113 ILE G N    1 
ATOM   3738 C CA   . ILE G 1 35 ? -7.652  20.608 5.030   1.00 6.75  ? 1113 ILE G CA   1 
ATOM   3739 C C    . ILE G 1 35 ? -7.657  21.526 6.248   1.00 7.29  ? 1113 ILE G C    1 
ATOM   3740 O O    . ILE G 1 35 ? -7.858  21.073 7.385   1.00 9.12  ? 1113 ILE G O    1 
ATOM   3741 C CB   . ILE G 1 35 ? -8.975  19.817 4.945   1.00 6.12  ? 1113 ILE G CB   1 
ATOM   3742 C CG1  . ILE G 1 35 ? -8.949  18.770 3.829   1.00 6.17  ? 1113 ILE G CG1  1 
ATOM   3743 C CG2  . ILE G 1 35 ? -10.174 20.785 4.833   1.00 6.30  ? 1113 ILE G CG2  1 
ATOM   3744 C CD1  . ILE G 1 35 ? -8.628  19.392 2.465   1.00 13.23 ? 1113 ILE G CD1  1 
ATOM   3745 H H    . ILE G 1 35 ? -6.716  18.952 5.506   1.00 11.34 ? 1113 ILE G H    1 
ATOM   3746 H HA   . ILE G 1 35 ? -7.554  21.153 4.234   1.00 8.25  ? 1113 ILE G HA   1 
ATOM   3747 H HB   . ILE G 1 35 ? -9.080  19.316 5.770   1.00 7.49  ? 1113 ILE G HB   1 
ATOM   3748 H HG12 . ILE G 1 35 ? -8.268  18.109 4.029   1.00 7.55  ? 1113 ILE G HG12 1 
ATOM   3749 H HG13 . ILE G 1 35 ? -9.818  18.344 3.771   1.00 7.55  ? 1113 ILE G HG13 1 
ATOM   3750 H HG21 . ILE G 1 35 ? -10.980 20.271 4.664   1.00 7.71  ? 1113 ILE G HG21 1 
ATOM   3751 H HG22 . ILE G 1 35 ? -10.263 21.276 5.664   1.00 7.71  ? 1113 ILE G HG22 1 
ATOM   3752 H HG23 . ILE G 1 35 ? -10.015 21.400 4.100   1.00 7.71  ? 1113 ILE G HG23 1 
ATOM   3753 H HD11 . ILE G 1 35 ? -8.783  18.731 1.772   1.00 16.03 ? 1113 ILE G HD11 1 
ATOM   3754 H HD12 . ILE G 1 35 ? -9.204  20.160 2.325   1.00 16.03 ? 1113 ILE G HD12 1 
ATOM   3755 H HD13 . ILE G 1 35 ? -7.699  19.670 2.456   1.00 16.03 ? 1113 ILE G HD13 1 
ATOM   3756 N N    . VAL G 1 36 ? -7.510  22.820 6.018   1.00 5.18  ? 1114 VAL G N    1 
ATOM   3757 C CA   . VAL G 1 36 ? -7.490  23.792 7.097   1.00 7.12  ? 1114 VAL G CA   1 
ATOM   3758 C C    . VAL G 1 36 ? -8.921  24.152 7.453   1.00 12.59 ? 1114 VAL G C    1 
ATOM   3759 O O    . VAL G 1 36 ? -9.687  24.596 6.596   1.00 10.47 ? 1114 VAL G O    1 
ATOM   3760 C CB   . VAL G 1 36 ? -6.685  25.040 6.709   1.00 9.33  ? 1114 VAL G CB   1 
ATOM   3761 C CG1  . VAL G 1 36 ? -6.578  25.991 7.883   1.00 9.95  ? 1114 VAL G CG1  1 
ATOM   3762 C CG2  . VAL G 1 36 ? -5.310  24.653 6.193   1.00 13.63 ? 1114 VAL G CG2  1 
ATOM   3763 H H    . VAL G 1 36 ? -7.418  23.165 5.235   1.00 6.36  ? 1114 VAL G H    1 
ATOM   3764 H HA   . VAL G 1 36 ? -7.071  23.393 7.876   1.00 8.69  ? 1114 VAL G HA   1 
ATOM   3765 H HB   . VAL G 1 36 ? -7.151  25.502 5.994   1.00 11.35 ? 1114 VAL G HB   1 
ATOM   3766 H HG11 . VAL G 1 36 ? -6.018  26.742 7.631   1.00 12.09 ? 1114 VAL G HG11 1 
ATOM   3767 H HG12 . VAL G 1 36 ? -7.465  26.305 8.118   1.00 12.09 ? 1114 VAL G HG12 1 
ATOM   3768 H HG13 . VAL G 1 36 ? -6.183  25.522 8.635   1.00 12.09 ? 1114 VAL G HG13 1 
ATOM   3769 H HG21 . VAL G 1 36 ? -4.792  25.459 6.042   1.00 16.51 ? 1114 VAL G HG21 1 
ATOM   3770 H HG22 . VAL G 1 36 ? -4.870  24.096 6.853   1.00 16.51 ? 1114 VAL G HG22 1 
ATOM   3771 H HG23 . VAL G 1 36 ? -5.412  24.164 5.361   1.00 16.51 ? 1114 VAL G HG23 1 
ATOM   3772 N N    . THR G 1 37 ? -9.284  23.945 8.716   1.00 10.42 ? 1115 THR G N    1 
ATOM   3773 C CA   . THR G 1 37 ? -10.631 24.193 9.204   1.00 10.73 ? 1115 THR G CA   1 
ATOM   3774 C C    . THR G 1 37 ? -10.670 25.206 10.335  1.00 18.13 ? 1115 THR G C    1 
ATOM   3775 O O    . THR G 1 37 ? -11.750 25.468 10.879  1.00 18.14 ? 1115 THR G O    1 
ATOM   3776 C CB   . THR G 1 37 ? -11.267 22.880 9.672   1.00 8.52  ? 1115 THR G CB   1 
ATOM   3777 O OG1  . THR G 1 37 ? -10.481 22.289 10.726  1.00 9.95  ? 1115 THR G OG1  1 
ATOM   3778 C CG2  . THR G 1 37 ? -11.365 21.898 8.531   1.00 8.12  ? 1115 THR G CG2  1 
ATOM   3779 H H    . THR G 1 37 ? -8.751  23.652 9.325   1.00 12.65 ? 1115 THR G H    1 
ATOM   3780 H HA   . THR G 1 37 ? -11.169 24.542 8.476   1.00 13.02 ? 1115 THR G HA   1 
ATOM   3781 H HB   . THR G 1 37 ? -12.160 23.068 10.002  1.00 10.38 ? 1115 THR G HB   1 
ATOM   3782 H HG1  . THR G 1 37 ? -10.529 22.762 11.420  1.00 12.09 ? 1115 THR G HG1  1 
ATOM   3783 H HG21 . THR G 1 37 ? -11.823 21.095 8.823   1.00 9.90  ? 1115 THR G HG21 1 
ATOM   3784 H HG22 . THR G 1 37 ? -11.860 22.292 7.795   1.00 9.90  ? 1115 THR G HG22 1 
ATOM   3785 H HG23 . THR G 1 37 ? -10.478 21.660 8.221   1.00 9.90  ? 1115 THR G HG23 1 
ATOM   3786 N N    . GLY G 1 38 ? -9.532  25.748 10.731  1.00 16.03 ? 1116 GLY G N    1 
ATOM   3787 C CA   . GLY G 1 38 ? -9.504  26.628 11.874  1.00 13.93 ? 1116 GLY G CA   1 
ATOM   3788 C C    . GLY G 1 38 ? -8.123  27.220 12.047  1.00 16.24 ? 1116 GLY G C    1 
ATOM   3789 O O    . GLY G 1 38 ? -7.140  26.792 11.428  1.00 13.09 ? 1116 GLY G O    1 
ATOM   3790 H H    . GLY G 1 38 ? -8.769  25.620 10.355  1.00 19.39 ? 1116 GLY G H    1 
ATOM   3791 H HA2  . GLY G 1 38 ? -10.140 27.350 11.750  1.00 16.87 ? 1116 GLY G HA2  1 
ATOM   3792 H HA3  . GLY G 1 38 ? -9.737  26.135 12.676  1.00 16.87 ? 1116 GLY G HA3  1 
ATOM   3793 N N    . GLU G 1 39 ? -8.054  28.191 12.940  1.00 15.49 ? 1117 GLU G N    1 
ATOM   3794 C CA   . GLU G 1 39 ? -6.820  28.898 13.230  1.00 16.94 ? 1117 GLU G CA   1 
ATOM   3795 C C    . GLU G 1 39 ? -6.693  28.987 14.735  1.00 14.51 ? 1117 GLU G C    1 
ATOM   3796 O O    . GLU G 1 39 ? -7.652  29.369 15.410  1.00 20.87 ? 1117 GLU G O    1 
ATOM   3797 C CB   . GLU G 1 39 ? -6.822  30.303 12.635  1.00 24.48 ? 1117 GLU G CB   1 
ATOM   3798 C CG   . GLU G 1 39 ? -6.116  30.423 11.304  1.00 32.85 ? 1117 GLU G CG   1 
ATOM   3799 C CD   . GLU G 1 39 ? -6.684  31.534 10.447  1.00 47.12 ? 1117 GLU G CD   1 
ATOM   3800 O OE1  . GLU G 1 39 ? -7.831  31.378 9.958   1.00 53.28 ? 1117 GLU G OE1  1 
ATOM   3801 O OE2  . GLU G 1 39 ? -5.999  32.569 10.279  1.00 50.57 ? 1117 GLU G OE2  1 
ATOM   3802 H H    . GLU G 1 39 ? -8.725  28.466 13.403  1.00 18.73 ? 1117 GLU G H    1 
ATOM   3803 H HA   . GLU G 1 39 ? -6.065  28.416 12.857  1.00 20.47 ? 1117 GLU G HA   1 
ATOM   3804 H HB2  . GLU G 1 39 ? -7.742  30.582 12.504  1.00 29.53 ? 1117 GLU G HB2  1 
ATOM   3805 H HB3  . GLU G 1 39 ? -6.378  30.902 13.256  1.00 29.53 ? 1117 GLU G HB3  1 
ATOM   3806 H HG2  . GLU G 1 39 ? -5.177  30.611 11.459  1.00 39.56 ? 1117 GLU G HG2  1 
ATOM   3807 H HG3  . GLU G 1 39 ? -6.211  29.588 10.819  1.00 39.56 ? 1117 GLU G HG3  1 
ATOM   3808 N N    . GLU G 1 40 ? -5.515  28.666 15.257  1.00 15.52 ? 1118 GLU G N    1 
ATOM   3809 C CA   . GLU G 1 40 ? -5.232  28.981 16.644  1.00 10.99 ? 1118 GLU G CA   1 
ATOM   3810 C C    . GLU G 1 40 ? -4.599  30.361 16.773  1.00 19.83 ? 1118 GLU G C    1 
ATOM   3811 O O    . GLU G 1 40 ? -5.013  31.171 17.600  1.00 17.44 ? 1118 GLU G O    1 
ATOM   3812 C CB   . GLU G 1 40 ? -4.319  27.929 17.257  1.00 15.82 ? 1118 GLU G CB   1 
ATOM   3813 C CG   . GLU G 1 40 ? -3.847  28.376 18.629  1.00 21.04 ? 1118 GLU G CG   1 
ATOM   3814 C CD   . GLU G 1 40 ? -3.201  27.274 19.406  1.00 23.07 ? 1118 GLU G CD   1 
ATOM   3815 O OE1  . GLU G 1 40 ? -3.965  26.399 19.871  1.00 22.69 ? 1118 GLU G OE1  1 
ATOM   3816 O OE2  . GLU G 1 40 ? -1.957  27.290 19.550  1.00 21.48 ? 1118 GLU G OE2  1 
ATOM   3817 H H    . GLU G 1 40 ? -4.878  28.273 14.834  1.00 18.77 ? 1118 GLU G H    1 
ATOM   3818 H HA   . GLU G 1 40 ? -6.064  28.970 17.143  1.00 13.33 ? 1118 GLU G HA   1 
ATOM   3819 H HB2  . GLU G 1 40 ? -4.803  27.094 17.352  1.00 19.13 ? 1118 GLU G HB2  1 
ATOM   3820 H HB3  . GLU G 1 40 ? -3.544  27.800 16.689  1.00 19.13 ? 1118 GLU G HB3  1 
ATOM   3821 H HG2  . GLU G 1 40 ? -3.197  29.089 18.523  1.00 25.39 ? 1118 GLU G HG2  1 
ATOM   3822 H HG3  . GLU G 1 40 ? -4.609  28.695 19.137  1.00 25.39 ? 1118 GLU G HG3  1 
ATOM   3823 N N    . ASP G 1 41 ? -3.568  30.625 15.985  1.00 22.25 ? 1119 ASP G N    1 
ATOM   3824 C CA   . ASP G 1 41 ? -2.973  31.945 15.884  1.00 21.77 ? 1119 ASP G CA   1 
ATOM   3825 C C    . ASP G 1 41 ? -2.205  31.979 14.577  1.00 22.41 ? 1119 ASP G C    1 
ATOM   3826 O O    . ASP G 1 41 ? -2.388  31.119 13.706  1.00 22.21 ? 1119 ASP G O    1 
ATOM   3827 C CB   . ASP G 1 41 ? -2.077  32.284 17.079  1.00 16.81 ? 1119 ASP G CB   1 
ATOM   3828 C CG   . ASP G 1 41 ? -0.933  31.338 17.243  1.00 18.84 ? 1119 ASP G CG   1 
ATOM   3829 O OD1  . ASP G 1 41 ? -0.580  30.635 16.277  1.00 24.08 ? 1119 ASP G OD1  1 
ATOM   3830 O OD2  . ASP G 1 41 ? -0.371  31.291 18.352  1.00 27.27 ? 1119 ASP G OD2  1 
ATOM   3831 H H    . ASP G 1 41 ? -3.185  30.039 15.485  1.00 26.84 ? 1119 ASP G H    1 
ATOM   3832 H HA   . ASP G 1 41 ? -3.687  32.601 15.872  1.00 26.27 ? 1119 ASP G HA   1 
ATOM   3833 H HB2  . ASP G 1 41 ? -1.713  33.175 16.957  1.00 20.32 ? 1119 ASP G HB2  1 
ATOM   3834 H HB3  . ASP G 1 41 ? -2.609  32.253 17.890  1.00 20.32 ? 1119 ASP G HB3  1 
ATOM   3835 N N    . GLN G 1 42 ? -1.361  32.992 14.428  1.00 21.22 ? 1120 GLN G N    1 
ATOM   3836 C CA   . GLN G 1 42 ? -0.678  33.189 13.154  1.00 26.32 ? 1120 GLN G CA   1 
ATOM   3837 C C    . GLN G 1 42 ? 0.260   32.043 12.830  1.00 17.19 ? 1120 GLN G C    1 
ATOM   3838 O O    . GLN G 1 42 ? 0.534   31.791 11.652  1.00 23.28 ? 1120 GLN G O    1 
ATOM   3839 C CB   . GLN G 1 42 ? 0.065   34.527 13.162  1.00 23.92 ? 1120 GLN G CB   1 
ATOM   3840 H H    . GLN G 1 42 ? -1.169  33.569 15.036  1.00 25.61 ? 1120 GLN G H    1 
ATOM   3841 H HA   . GLN G 1 42 ? -1.339  33.224 12.445  1.00 31.73 ? 1120 GLN G HA   1 
ATOM   3842 N N    . GLU G 1 43 ? 0.748   31.343 13.844  1.00 21.38 ? 1121 GLU G N    1 
ATOM   3843 C CA   . GLU G 1 43 ? 1.722   30.283 13.656  1.00 20.08 ? 1121 GLU G CA   1 
ATOM   3844 C C    . GLU G 1 43 ? 1.147   28.875 13.756  1.00 15.17 ? 1121 GLU G C    1 
ATOM   3845 O O    . GLU G 1 43 ? 1.853   27.913 13.416  1.00 14.54 ? 1121 GLU G O    1 
ATOM   3846 C CB   . GLU G 1 43 ? 2.852   30.449 14.674  1.00 22.64 ? 1121 GLU G CB   1 
ATOM   3847 C CG   . GLU G 1 43 ? 3.578   31.764 14.436  1.00 34.07 ? 1121 GLU G CG   1 
ATOM   3848 C CD   . GLU G 1 43 ? 4.996   31.771 14.947  1.00 47.26 ? 1121 GLU G CD   1 
ATOM   3849 O OE1  . GLU G 1 43 ? 5.890   32.169 14.173  1.00 56.08 ? 1121 GLU G OE1  1 
ATOM   3850 O OE2  . GLU G 1 43 ? 5.212   31.406 16.130  1.00 50.02 ? 1121 GLU G OE2  1 
ATOM   3851 H H    . GLU G 1 43 ? 0.527   31.467 14.666  1.00 25.80 ? 1121 GLU G H    1 
ATOM   3852 H HA   . GLU G 1 43 ? 2.092   30.362 12.763  1.00 24.24 ? 1121 GLU G HA   1 
ATOM   3853 H HB2  . GLU G 1 43 ? 2.484   30.454 15.571  1.00 27.32 ? 1121 GLU G HB2  1 
ATOM   3854 H HB3  . GLU G 1 43 ? 3.486   29.721 14.579  1.00 27.32 ? 1121 GLU G HB3  1 
ATOM   3855 H HG2  . GLU G 1 43 ? 3.606   31.938 13.482  1.00 41.03 ? 1121 GLU G HG2  1 
ATOM   3856 H HG3  . GLU G 1 43 ? 3.096   32.474 14.888  1.00 41.03 ? 1121 GLU G HG3  1 
ATOM   3857 N N    . TRP G 1 44 ? -0.089  28.727 14.217  1.00 15.96 ? 1122 TRP G N    1 
ATOM   3858 C CA   . TRP G 1 44 ? -0.710  27.429 14.427  1.00 13.01 ? 1122 TRP G CA   1 
ATOM   3859 C C    . TRP G 1 44 ? -2.117  27.444 13.850  1.00 12.22 ? 1122 TRP G C    1 
ATOM   3860 O O    . TRP G 1 44 ? -2.939  28.268 14.244  1.00 10.68 ? 1122 TRP G O    1 
ATOM   3861 C CB   . TRP G 1 44 ? -0.747  27.108 15.914  1.00 17.92 ? 1122 TRP G CB   1 
ATOM   3862 C CG   . TRP G 1 44 ? 0.595   26.847 16.511  1.00 11.73 ? 1122 TRP G CG   1 
ATOM   3863 C CD1  . TRP G 1 44 ? 1.430   27.753 17.101  1.00 12.15 ? 1122 TRP G CD1  1 
ATOM   3864 C CD2  . TRP G 1 44 ? 1.256   25.598 16.575  1.00 8.34  ? 1122 TRP G CD2  1 
ATOM   3865 N NE1  . TRP G 1 44 ? 2.550   27.134 17.553  1.00 14.89 ? 1122 TRP G NE1  1 
ATOM   3866 C CE2  . TRP G 1 44 ? 2.483   25.808 17.223  1.00 14.00 ? 1122 TRP G CE2  1 
ATOM   3867 C CE3  . TRP G 1 44 ? 0.940   24.317 16.139  1.00 9.43  ? 1122 TRP G CE3  1 
ATOM   3868 C CZ2  . TRP G 1 44 ? 3.374   24.785 17.470  1.00 13.60 ? 1122 TRP G CZ2  1 
ATOM   3869 C CZ3  . TRP G 1 44 ? 1.820   23.292 16.397  1.00 11.61 ? 1122 TRP G CZ3  1 
ATOM   3870 C CH2  . TRP G 1 44 ? 3.034   23.537 17.041  1.00 13.67 ? 1122 TRP G CH2  1 
ATOM   3871 H H    . TRP G 1 44 ? -0.603  29.386 14.422  1.00 19.29 ? 1122 TRP G H    1 
ATOM   3872 H HA   . TRP G 1 44 ? -0.208  26.744 13.958  1.00 15.76 ? 1122 TRP G HA   1 
ATOM   3873 H HB2  . TRP G 1 44 ? -1.138  27.861 16.385  1.00 21.65 ? 1122 TRP G HB2  1 
ATOM   3874 H HB3  . TRP G 1 44 ? -1.290  26.315 16.048  1.00 21.65 ? 1122 TRP G HB3  1 
ATOM   3875 H HD1  . TRP G 1 44 ? 1.256   28.663 17.181  1.00 14.72 ? 1122 TRP G HD1  1 
ATOM   3876 H HE1  . TRP G 1 44 ? 3.196   27.513 17.977  1.00 18.01 ? 1122 TRP G HE1  1 
ATOM   3877 H HE3  . TRP G 1 44 ? 0.146   24.155 15.681  1.00 11.46 ? 1122 TRP G HE3  1 
ATOM   3878 H HZ2  . TRP G 1 44 ? 4.177   24.941 17.912  1.00 16.46 ? 1122 TRP G HZ2  1 
ATOM   3879 H HZ3  . TRP G 1 44 ? 1.604   22.425 16.139  1.00 14.08 ? 1122 TRP G HZ3  1 
ATOM   3880 H HH2  . TRP G 1 44 ? 3.625   22.833 17.181  1.00 16.55 ? 1122 TRP G HH2  1 
ATOM   3881 N N    . TRP G 1 45 ? -2.381  26.529 12.937  1.00 8.94  ? 1123 TRP G N    1 
ATOM   3882 C CA   . TRP G 1 45 ? -3.687  26.349 12.340  1.00 13.04 ? 1123 TRP G CA   1 
ATOM   3883 C C    . TRP G 1 45 ? -4.245  25.019 12.786  1.00 9.26  ? 1123 TRP G C    1 
ATOM   3884 O O    . TRP G 1 45 ? -3.576  24.252 13.476  1.00 11.35 ? 1123 TRP G O    1 
ATOM   3885 C CB   . TRP G 1 45 ? -3.577  26.418 10.825  1.00 8.57  ? 1123 TRP G CB   1 
ATOM   3886 C CG   . TRP G 1 45 ? -3.347  27.804 10.367  1.00 11.45 ? 1123 TRP G CG   1 
ATOM   3887 C CD1  . TRP G 1 45 ? -3.326  28.932 11.134  1.00 13.46 ? 1123 TRP G CD1  1 
ATOM   3888 C CD2  . TRP G 1 45 ? -3.094  28.225 9.030   1.00 17.26 ? 1123 TRP G CD2  1 
ATOM   3889 N NE1  . TRP G 1 45 ? -3.090  30.035 10.350  1.00 17.78 ? 1123 TRP G NE1  1 
ATOM   3890 C CE2  . TRP G 1 45 ? -2.942  29.623 9.053   1.00 15.71 ? 1123 TRP G CE2  1 
ATOM   3891 C CE3  . TRP G 1 45 ? -2.966  27.555 7.818   1.00 18.38 ? 1123 TRP G CE3  1 
ATOM   3892 C CZ2  . TRP G 1 45 ? -2.686  30.355 7.914   1.00 17.23 ? 1123 TRP G CZ2  1 
ATOM   3893 C CZ3  . TRP G 1 45 ? -2.720  28.293 6.690   1.00 22.86 ? 1123 TRP G CZ3  1 
ATOM   3894 C CH2  . TRP G 1 45 ? -2.575  29.673 6.745   1.00 16.50 ? 1123 TRP G CH2  1 
ATOM   3895 H H    . TRP G 1 45 ? -1.794  25.979 12.634  1.00 10.88 ? 1123 TRP G H    1 
ATOM   3896 H HA   . TRP G 1 45 ? -4.297  27.047 12.624  1.00 15.80 ? 1123 TRP G HA   1 
ATOM   3897 H HB2  . TRP G 1 45 ? -2.832  25.871 10.531  1.00 10.43 ? 1123 TRP G HB2  1 
ATOM   3898 H HB3  . TRP G 1 45 ? -4.401  26.097 10.427  1.00 10.43 ? 1123 TRP G HB3  1 
ATOM   3899 H HD1  . TRP G 1 45 ? -3.453  28.952 12.055  1.00 16.30 ? 1123 TRP G HD1  1 
ATOM   3900 H HE1  . TRP G 1 45 ? -3.044  30.848 10.627  1.00 21.49 ? 1123 TRP G HE1  1 
ATOM   3901 H HE3  . TRP G 1 45 ? -3.045  26.630 7.774   1.00 22.21 ? 1123 TRP G HE3  1 
ATOM   3902 H HZ2  . TRP G 1 45 ? -2.592  31.280 7.944   1.00 20.82 ? 1123 TRP G HZ2  1 
ATOM   3903 H HZ3  . TRP G 1 45 ? -2.649  27.861 5.870   1.00 27.58 ? 1123 TRP G HZ3  1 
ATOM   3904 H HH2  . TRP G 1 45 ? -2.398  30.142 5.962   1.00 19.95 ? 1123 TRP G HH2  1 
ATOM   3905 N N    . ILE G 1 46 ? -5.491  24.766 12.423  1.00 9.99  ? 1124 ILE G N    1 
ATOM   3906 C CA   . ILE G 1 46 ? -6.180  23.539 12.796  1.00 9.73  ? 1124 ILE G CA   1 
ATOM   3907 C C    . ILE G 1 46 ? -6.725  22.885 11.539  1.00 5.20  ? 1124 ILE G C    1 
ATOM   3908 O O    . ILE G 1 46 ? -7.293  23.566 10.685  1.00 8.90  ? 1124 ILE G O    1 
ATOM   3909 C CB   . ILE G 1 46 ? -7.322  23.819 13.795  1.00 11.33 ? 1124 ILE G CB   1 
ATOM   3910 C CG1  . ILE G 1 46 ? -6.841  24.806 14.853  1.00 14.82 ? 1124 ILE G CG1  1 
ATOM   3911 C CG2  . ILE G 1 46 ? -7.791  22.521 14.444  1.00 13.35 ? 1124 ILE G CG2  1 
ATOM   3912 C CD1  . ILE G 1 46 ? -7.916  25.171 15.880  1.00 17.35 ? 1124 ILE G CD1  1 
ATOM   3913 H H    . ILE G 1 46 ? -5.970  25.301 11.950  1.00 12.13 ? 1124 ILE G H    1 
ATOM   3914 H HA   . ILE G 1 46 ? -5.548  22.928 13.207  1.00 11.82 ? 1124 ILE G HA   1 
ATOM   3915 H HB   . ILE G 1 46 ? -8.073  24.206 13.318  1.00 13.74 ? 1124 ILE G HB   1 
ATOM   3916 H HG12 . ILE G 1 46 ? -6.094  24.412 15.332  1.00 17.93 ? 1124 ILE G HG12 1 
ATOM   3917 H HG13 . ILE G 1 46 ? -6.559  25.623 14.414  1.00 17.93 ? 1124 ILE G HG13 1 
ATOM   3918 H HG21 . ILE G 1 46 ? -8.583  22.701 14.973  1.00 16.17 ? 1124 ILE G HG21 1 
ATOM   3919 H HG22 . ILE G 1 46 ? -7.996  21.876 13.749  1.00 16.17 ? 1124 ILE G HG22 1 
ATOM   3920 H HG23 . ILE G 1 46 ? -7.083  22.180 15.014  1.00 16.17 ? 1124 ILE G HG23 1 
ATOM   3921 H HD11 . ILE G 1 46 ? -7.608  25.926 16.405  1.00 20.97 ? 1124 ILE G HD11 1 
ATOM   3922 H HD12 . ILE G 1 46 ? -8.733  25.405 15.412  1.00 20.97 ? 1124 ILE G HD12 1 
ATOM   3923 H HD13 . ILE G 1 46 ? -8.073  24.408 16.458  1.00 20.97 ? 1124 ILE G HD13 1 
ATOM   3924 N N    . GLY G 1 47 ? -6.617  21.565 11.454  1.00 4.08  ? 1125 GLY G N    1 
ATOM   3925 C CA   . GLY G 1 47 ? -7.140  20.904 10.280  1.00 4.77  ? 1125 GLY G CA   1 
ATOM   3926 C C    . GLY G 1 47 ? -7.074  19.402 10.388  1.00 4.71  ? 1125 GLY G C    1 
ATOM   3927 O O    . GLY G 1 47 ? -6.888  18.831 11.468  1.00 5.90  ? 1125 GLY G O    1 
ATOM   3928 H H    . GLY G 1 47 ? -6.257  21.052 12.043  1.00 5.04  ? 1125 GLY G H    1 
ATOM   3929 H HA2  . GLY G 1 47 ? -8.068  21.160 10.154  1.00 5.87  ? 1125 GLY G HA2  1 
ATOM   3930 H HA3  . GLY G 1 47 ? -6.629  21.177 9.503   1.00 5.87  ? 1125 GLY G HA3  1 
ATOM   3931 N N    . HIS G 1 48 ? -7.261  18.762 9.240   1.00 4.16  ? 1126 HIS G N    1 
ATOM   3932 C CA   . HIS G 1 48 ? -7.182  17.320 9.177   1.00 4.79  ? 1126 HIS G CA   1 
ATOM   3933 C C    . HIS G 1 48 ? -6.635  16.876 7.852   1.00 5.08  ? 1126 HIS G C    1 
ATOM   3934 O O    . HIS G 1 48 ? -6.611  17.640 6.891   1.00 9.88  ? 1126 HIS G O    1 
ATOM   3935 C CB   . HIS G 1 48 ? -8.522  16.676 9.348   1.00 6.55  ? 1126 HIS G CB   1 
ATOM   3936 C CG   . HIS G 1 48 ? -9.552  17.185 8.406   1.00 5.11  ? 1126 HIS G CG   1 
ATOM   3937 N ND1  . HIS G 1 48 ? -10.342 18.273 8.694   1.00 12.16 ? 1126 HIS G ND1  1 
ATOM   3938 C CD2  . HIS G 1 48 ? -9.926  16.752 7.178   1.00 6.55  ? 1126 HIS G CD2  1 
ATOM   3939 C CE1  . HIS G 1 48 ? -11.178 18.479 7.684   1.00 9.75  ? 1126 HIS G CE1  1 
ATOM   3940 N NE2  . HIS G 1 48 ? -10.973 17.544 6.774   1.00 9.61  ? 1126 HIS G NE2  1 
ATOM   3941 H H    . HIS G 1 48 ? -7.434  19.145 8.489   1.00 5.14  ? 1126 HIS G H    1 
ATOM   3942 H HA   . HIS G 1 48 ? -6.578  17.041 9.883   1.00 5.89  ? 1126 HIS G HA   1 
ATOM   3943 H HB2  . HIS G 1 48 ? -8.431  15.722 9.201   1.00 8.01  ? 1126 HIS G HB2  1 
ATOM   3944 H HB3  . HIS G 1 48 ? -8.836  16.845 10.250  1.00 8.01  ? 1126 HIS G HB3  1 
ATOM   3945 H HD2  . HIS G 1 48 ? -9.546  16.052 6.699   1.00 8.01  ? 1126 HIS G HD2  1 
ATOM   3946 H HE1  . HIS G 1 48 ? -11.802 19.166 7.626   1.00 11.84 ? 1126 HIS G HE1  1 
ATOM   3947 H HE2  . HIS G 1 48 ? -11.421 17.447 6.047   1.00 11.68 ? 1126 HIS G HE2  1 
ATOM   3948 N N    . ILE G 1 49 ? -6.201  15.618 7.810   1.00 8.49  ? 1127 ILE G N    1 
ATOM   3949 C CA   . ILE G 1 49 ? -5.555  15.103 6.606   1.00 13.98 ? 1127 ILE G CA   1 
ATOM   3950 C C    . ILE G 1 49 ? -6.606  14.876 5.524   1.00 10.44 ? 1127 ILE G C    1 
ATOM   3951 O O    . ILE G 1 49 ? -7.618  14.193 5.746   1.00 8.85  ? 1127 ILE G O    1 
ATOM   3952 C CB   . ILE G 1 49 ? -4.793  13.809 6.919   1.00 11.49 ? 1127 ILE G CB   1 
ATOM   3953 C CG1  . ILE G 1 49 ? -3.767  14.062 8.033   1.00 14.97 ? 1127 ILE G CG1  1 
ATOM   3954 C CG2  . ILE G 1 49 ? -4.124  13.226 5.638   1.00 10.12 ? 1127 ILE G CG2  1 
ATOM   3955 C CD1  . ILE G 1 49 ? -2.467  14.761 7.560   1.00 14.01 ? 1127 ILE G CD1  1 
ATOM   3956 H H    . ILE G 1 49 ? -6.266  15.052 8.454   1.00 10.33 ? 1127 ILE G H    1 
ATOM   3957 H HA   . ILE G 1 49 ? -4.921  15.761 6.282   1.00 16.92 ? 1127 ILE G HA   1 
ATOM   3958 H HB   . ILE G 1 49 ? -5.426  13.145 7.235   1.00 13.93 ? 1127 ILE G HB   1 
ATOM   3959 H HG12 . ILE G 1 49 ? -4.175  14.627 8.707   1.00 18.11 ? 1127 ILE G HG12 1 
ATOM   3960 H HG13 . ILE G 1 49 ? -3.516  13.210 8.422   1.00 18.11 ? 1127 ILE G HG13 1 
ATOM   3961 H HG21 . ILE G 1 49 ? -3.495  12.535 5.897   1.00 12.29 ? 1127 ILE G HG21 1 
ATOM   3962 H HG22 . ILE G 1 49 ? -4.811  12.851 5.065   1.00 12.29 ? 1127 ILE G HG22 1 
ATOM   3963 H HG23 . ILE G 1 49 ? -3.659  13.939 5.173   1.00 12.29 ? 1127 ILE G HG23 1 
ATOM   3964 H HD11 . ILE G 1 49 ? -1.989  15.097 8.335   1.00 16.96 ? 1127 ILE G HD11 1 
ATOM   3965 H HD12 . ILE G 1 49 ? -1.917  14.118 7.086   1.00 16.96 ? 1127 ILE G HD12 1 
ATOM   3966 H HD13 . ILE G 1 49 ? -2.699  15.496 6.971   1.00 16.96 ? 1127 ILE G HD13 1 
ATOM   3967 N N    . GLU G 1 50 ? -6.357  15.419 4.337   1.00 9.09  ? 1128 GLU G N    1 
ATOM   3968 C CA   . GLU G 1 50 ? -7.237  15.149 3.215   1.00 12.89 ? 1128 GLU G CA   1 
ATOM   3969 C C    . GLU G 1 50 ? -7.184  13.673 2.853   1.00 13.57 ? 1128 GLU G C    1 
ATOM   3970 O O    . GLU G 1 50 ? -6.108  13.121 2.599   1.00 10.66 ? 1128 GLU G O    1 
ATOM   3971 C CB   . GLU G 1 50 ? -6.842  16.009 2.024   1.00 15.51 ? 1128 GLU G CB   1 
ATOM   3972 C CG   . GLU G 1 50 ? -7.741  15.843 0.823   1.00 12.25 ? 1128 GLU G CG   1 
ATOM   3973 C CD   . GLU G 1 50 ? -7.175  16.552 -0.409  1.00 20.33 ? 1128 GLU G CD   1 
ATOM   3974 O OE1  . GLU G 1 50 ? -6.141  16.091 -0.956  1.00 17.24 ? 1128 GLU G OE1  1 
ATOM   3975 O OE2  . GLU G 1 50 ? -7.767  17.582 -0.799  1.00 28.89 ? 1128 GLU G OE2  1 
ATOM   3976 H H    . GLU G 1 50 ? -5.694  15.938 4.161   1.00 11.05 ? 1128 GLU G H    1 
ATOM   3977 H HA   . GLU G 1 50 ? -8.149  15.373 3.458   1.00 15.61 ? 1128 GLU G HA   1 
ATOM   3978 H HB2  . GLU G 1 50 ? -6.873  16.942 2.290   1.00 18.76 ? 1128 GLU G HB2  1 
ATOM   3979 H HB3  . GLU G 1 50 ? -5.941  15.771 1.754   1.00 18.76 ? 1128 GLU G HB3  1 
ATOM   3980 H HG2  . GLU G 1 50 ? -7.830  14.899 0.617   1.00 14.84 ? 1128 GLU G HG2  1 
ATOM   3981 H HG3  . GLU G 1 50 ? -8.612  16.223 1.020   1.00 14.84 ? 1128 GLU G HG3  1 
ATOM   3982 N N    . GLY G 1 51 ? -8.363  13.037 2.824   1.00 11.36 ? 1129 GLY G N    1 
ATOM   3983 C CA   . GLY G 1 51 ? -8.480  11.603 2.634   1.00 9.67  ? 1129 GLY G CA   1 
ATOM   3984 C C    . GLY G 1 51 ? -8.451  10.793 3.919   1.00 14.16 ? 1129 GLY G C    1 
ATOM   3985 O O    . GLY G 1 51 ? -8.824  9.621  3.897   1.00 13.49 ? 1129 GLY G O    1 
ATOM   3986 H H    . GLY G 1 51 ? -9.122  13.432 2.915   1.00 13.78 ? 1129 GLY G H    1 
ATOM   3987 H HA2  . GLY G 1 51 ? -9.318  11.415 2.183   1.00 11.75 ? 1129 GLY G HA2  1 
ATOM   3988 H HA3  . GLY G 1 51 ? -7.746  11.302 2.075   1.00 11.75 ? 1129 GLY G HA3  1 
ATOM   3989 N N    . GLN G 1 52 ? -8.029  11.381 5.041   1.00 11.12 ? 1130 GLN G N    1 
ATOM   3990 C CA   . GLN G 1 52 ? -7.992  10.687 6.341   1.00 13.83 ? 1130 GLN G CA   1 
ATOM   3991 C C    . GLN G 1 52 ? -8.458  11.649 7.436   1.00 12.68 ? 1130 GLN G C    1 
ATOM   3992 O O    . GLN G 1 52 ? -7.682  12.060 8.304   1.00 13.96 ? 1130 GLN G O    1 
ATOM   3993 C CB   . GLN G 1 52 ? -6.593  10.151 6.655   1.00 14.47 ? 1130 GLN G CB   1 
ATOM   3994 C CG   . GLN G 1 52 ? -6.059  9.122  5.688   1.00 16.57 ? 1130 GLN G CG   1 
ATOM   3995 C CD   . GLN G 1 52 ? -4.549  8.940  5.836   1.00 24.39 ? 1130 GLN G CD   1 
ATOM   3996 O OE1  . GLN G 1 52 ? -4.078  8.497  6.871   1.00 22.70 ? 1130 GLN G OE1  1 
ATOM   3997 N NE2  . GLN G 1 52 ? -3.794  9.287  4.800   1.00 28.62 ? 1130 GLN G NE2  1 
ATOM   3998 H H    . GLN G 1 52 ? -7.754  12.195 5.080   1.00 13.49 ? 1130 GLN G H    1 
ATOM   3999 H HA   . GLN G 1 52 ? -8.604  9.936  6.302   1.00 16.75 ? 1130 GLN G HA   1 
ATOM   4000 H HB2  . GLN G 1 52 ? -5.973  10.898 6.653   1.00 17.51 ? 1130 GLN G HB2  1 
ATOM   4001 H HB3  . GLN G 1 52 ? -6.614  9.739  7.533   1.00 17.51 ? 1130 GLN G HB3  1 
ATOM   4002 H HG2  . GLN G 1 52 ? -6.487  8.269  5.860   1.00 20.03 ? 1130 GLN G HG2  1 
ATOM   4003 H HG3  . GLN G 1 52 ? -6.244  9.409  4.780   1.00 20.03 ? 1130 GLN G HG3  1 
ATOM   4004 H HE21 . GLN G 1 52 ? -4.160  9.598  4.087   1.00 34.49 ? 1130 GLN G HE21 1 
ATOM   4005 H HE22 . GLN G 1 52 ? -2.940  9.200  4.843   1.00 34.49 ? 1130 GLN G HE22 1 
ATOM   4006 N N    . PRO G 1 53 ? -9.749  12.012 7.409   1.00 12.70 ? 1131 PRO G N    1 
ATOM   4007 C CA   . PRO G 1 53 ? -10.212 13.130 8.255   1.00 9.08  ? 1131 PRO G CA   1 
ATOM   4008 C C    . PRO G 1 53 ? -10.124 12.852 9.751   1.00 9.15  ? 1131 PRO G C    1 
ATOM   4009 O O    . PRO G 1 53 ? -10.194 13.794 10.558  1.00 7.20  ? 1131 PRO G O    1 
ATOM   4010 C CB   . PRO G 1 53 ? -11.675 13.319 7.820   1.00 9.43  ? 1131 PRO G CB   1 
ATOM   4011 C CG   . PRO G 1 53 ? -11.898 12.390 6.645   1.00 16.03 ? 1131 PRO G CG   1 
ATOM   4012 C CD   . PRO G 1 53 ? -10.862 11.322 6.739   1.00 14.47 ? 1131 PRO G CD   1 
ATOM   4013 H HA   . PRO G 1 53 ? -9.701  13.928 8.046   1.00 11.04 ? 1131 PRO G HA   1 
ATOM   4014 H HB2  . PRO G 1 53 ? -12.264 13.087 8.556   1.00 11.47 ? 1131 PRO G HB2  1 
ATOM   4015 H HB3  . PRO G 1 53 ? -11.819 14.242 7.559   1.00 11.47 ? 1131 PRO G HB3  1 
ATOM   4016 H HG2  . PRO G 1 53 ? -12.788 12.007 6.700   1.00 19.39 ? 1131 PRO G HG2  1 
ATOM   4017 H HG3  . PRO G 1 53 ? -11.801 12.886 5.818   1.00 19.39 ? 1131 PRO G HG3  1 
ATOM   4018 H HD2  . PRO G 1 53 ? -11.179 10.575 7.272   1.00 17.51 ? 1131 PRO G HD2  1 
ATOM   4019 H HD3  . PRO G 1 53 ? -10.600 11.012 5.858   1.00 17.51 ? 1131 PRO G HD3  1 
ATOM   4020 N N    . GLU G 1 54 ? -10.007 11.600 10.153  1.00 8.21  ? 1132 GLU G N    1 
ATOM   4021 C CA   . GLU G 1 54 ? -9.830  11.373 11.576  1.00 10.73 ? 1132 GLU G CA   1 
ATOM   4022 C C    . GLU G 1 54 ? -8.438  11.745 12.061  1.00 12.46 ? 1132 GLU G C    1 
ATOM   4023 O O    . GLU G 1 54 ? -8.233  11.841 13.278  1.00 12.32 ? 1132 GLU G O    1 
ATOM   4024 C CB   . GLU G 1 54 ? -10.147 9.922  11.936  1.00 20.16 ? 1132 GLU G CB   1 
ATOM   4025 C CG   . GLU G 1 54 ? -11.472 9.389  11.320  1.00 30.67 ? 1132 GLU G CG   1 
ATOM   4026 C CD   . GLU G 1 54 ? -12.744 9.930  11.994  1.00 37.81 ? 1132 GLU G CD   1 
ATOM   4027 O OE1  . GLU G 1 54 ? -12.651 10.444 13.127  1.00 43.00 ? 1132 GLU G OE1  1 
ATOM   4028 O OE2  . GLU G 1 54 ? -13.844 9.818  11.377  1.00 47.56 ? 1132 GLU G OE2  1 
ATOM   4029 H H    . GLU G 1 54 ? -10.025 10.903 9.650   1.00 10.00 ? 1132 GLU G H    1 
ATOM   4030 H HA   . GLU G 1 54 ? -10.466 11.924 12.058  1.00 13.02 ? 1132 GLU G HA   1 
ATOM   4031 H HB2  . GLU G 1 54 ? -9.426  9.358  11.617  1.00 24.34 ? 1132 GLU G HB2  1 
ATOM   4032 H HB3  . GLU G 1 54 ? -10.222 9.851  12.901  1.00 24.34 ? 1132 GLU G HB3  1 
ATOM   4033 H HG2  . GLU G 1 54 ? -11.503 9.644  10.384  1.00 36.95 ? 1132 GLU G HG2  1 
ATOM   4034 H HG3  . GLU G 1 54 ? -11.485 8.422  11.400  1.00 36.95 ? 1132 GLU G HG3  1 
ATOM   4035 N N    . ARG G 1 55 ? -7.485  11.942 11.156  1.00 13.15 ? 1133 ARG G N    1 
ATOM   4036 C CA   . ARG G 1 55 ? -6.174  12.472 11.524  1.00 8.14  ? 1133 ARG G CA   1 
ATOM   4037 C C    . ARG G 1 55 ? -6.274  13.995 11.498  1.00 8.71  ? 1133 ARG G C    1 
ATOM   4038 O O    . ARG G 1 55 ? -6.298  14.622 10.431  1.00 9.10  ? 1133 ARG G O    1 
ATOM   4039 C CB   . ARG G 1 55 ? -5.107  11.960 10.575  1.00 10.45 ? 1133 ARG G CB   1 
ATOM   4040 C CG   . ARG G 1 55 ? -4.861  10.488 10.699  1.00 9.79  ? 1133 ARG G CG   1 
ATOM   4041 C CD   . ARG G 1 55 ? -3.837  10.032 9.693   1.00 16.41 ? 1133 ARG G CD   1 
ATOM   4042 N NE   . ARG G 1 55 ? -2.587  10.767 9.822   1.00 9.17  ? 1133 ARG G NE   1 
ATOM   4043 C CZ   . ARG G 1 55 ? -1.814  11.103 8.797   1.00 10.21 ? 1133 ARG G CZ   1 
ATOM   4044 N NH1  . ARG G 1 55 ? -2.074  10.689 7.573   1.00 14.87 ? 1133 ARG G NH1  1 
ATOM   4045 N NH2  . ARG G 1 55 ? -0.768  11.891 9.000   1.00 9.86  ? 1133 ARG G NH2  1 
ATOM   4046 H H    . ARG G 1 55 ? -7.573  11.776 10.317  1.00 15.92 ? 1133 ARG G H    1 
ATOM   4047 H HA   . ARG G 1 55 ? -5.939  12.188 12.422  1.00 9.91  ? 1133 ARG G HA   1 
ATOM   4048 H HB2  . ARG G 1 55 ? -5.386  12.141 9.664   1.00 12.69 ? 1133 ARG G HB2  1 
ATOM   4049 H HB3  . ARG G 1 55 ? -4.273  12.419 10.764  1.00 12.69 ? 1133 ARG G HB3  1 
ATOM   4050 H HG2  . ARG G 1 55 ? -4.529  10.288 11.588  1.00 11.89 ? 1133 ARG G HG2  1 
ATOM   4051 H HG3  . ARG G 1 55 ? -5.688  10.006 10.538  1.00 11.89 ? 1133 ARG G HG3  1 
ATOM   4052 H HD2  . ARG G 1 55 ? -3.652  9.090  9.830   1.00 19.84 ? 1133 ARG G HD2  1 
ATOM   4053 H HD3  . ARG G 1 55 ? -4.183  10.176 8.798   1.00 19.84 ? 1133 ARG G HD3  1 
ATOM   4054 H HE   . ARG G 1 55 ? -2.333  10.996 10.611  1.00 11.15 ? 1133 ARG G HE   1 
ATOM   4055 H HH11 . ARG G 1 55 ? -2.758  10.189 7.425   1.00 17.99 ? 1133 ARG G HH11 1 
ATOM   4056 H HH12 . ARG G 1 55 ? -1.560  10.919 6.923   1.00 17.99 ? 1133 ARG G HH12 1 
ATOM   4057 H HH21 . ARG G 1 55 ? -0.595  12.180 9.792   1.00 11.98 ? 1133 ARG G HH21 1 
ATOM   4058 H HH22 . ARG G 1 55 ? -0.263  12.114 8.341   1.00 11.98 ? 1133 ARG G HH22 1 
ATOM   4059 N N    . LYS G 1 56 ? -6.321  14.608 12.676  1.00 6.59  ? 1134 LYS G N    1 
ATOM   4060 C CA   . LYS G 1 56 ? -6.669  16.021 12.745  1.00 8.44  ? 1134 LYS G CA   1 
ATOM   4061 C C    . LYS G 1 56 ? -6.052  16.658 13.969  1.00 7.84  ? 1134 LYS G C    1 
ATOM   4062 O O    . LYS G 1 56 ? -5.713  15.979 14.932  1.00 14.45 ? 1134 LYS G O    1 
ATOM   4063 C CB   . LYS G 1 56 ? -8.188  16.214 12.807  1.00 6.97  ? 1134 LYS G CB   1 
ATOM   4064 C CG   . LYS G 1 56 ? -8.764  15.538 13.997  1.00 7.23  ? 1134 LYS G CG   1 
ATOM   4065 C CD   . LYS G 1 56 ? -10.282 15.486 13.957  1.00 14.02 ? 1134 LYS G CD   1 
ATOM   4066 C CE   . LYS G 1 56 ? -10.862 15.200 15.318  1.00 12.89 ? 1134 LYS G CE   1 
ATOM   4067 N NZ   . LYS G 1 56 ? -12.303 15.583 15.223  1.00 22.64 ? 1134 LYS G NZ   1 
ATOM   4068 H H    . LYS G 1 56 ? -6.159  14.235 13.434  1.00 8.06  ? 1134 LYS G H    1 
ATOM   4069 H HA   . LYS G 1 56 ? -6.307  16.457 11.957  1.00 10.28 ? 1134 LYS G HA   1 
ATOM   4070 H HB2  . LYS G 1 56 ? -8.391  17.161 12.864  1.00 8.51  ? 1134 LYS G HB2  1 
ATOM   4071 H HB3  . LYS G 1 56 ? -8.594  15.835 12.012  1.00 8.51  ? 1134 LYS G HB3  1 
ATOM   4072 H HG2  . LYS G 1 56 ? -8.433  14.627 14.036  1.00 8.82  ? 1134 LYS G HG2  1 
ATOM   4073 H HG3  . LYS G 1 56 ? -8.500  16.021 14.796  1.00 8.82  ? 1134 LYS G HG3  1 
ATOM   4074 H HD2  . LYS G 1 56 ? -10.624 16.342 13.654  1.00 16.97 ? 1134 LYS G HD2  1 
ATOM   4075 H HD3  . LYS G 1 56 ? -10.564 14.783 13.351  1.00 16.97 ? 1134 LYS G HD3  1 
ATOM   4076 H HE2  . LYS G 1 56 ? -10.784 14.257 15.534  1.00 15.62 ? 1134 LYS G HE2  1 
ATOM   4077 H HE3  . LYS G 1 56 ? -10.422 15.734 15.999  1.00 15.62 ? 1134 LYS G HE3  1 
ATOM   4078 H HZ1  . LYS G 1 56 ? -12.431 16.383 15.591  1.00 27.32 ? 1134 LYS G HZ1  1 
ATOM   4079 H HZ2  . LYS G 1 56 ? -12.554 15.615 14.369  1.00 27.32 ? 1134 LYS G HZ2  1 
ATOM   4080 H HZ3  . LYS G 1 56 ? -12.806 14.985 15.649  1.00 27.32 ? 1134 LYS G HZ3  1 
ATOM   4081 N N    . GLY G 1 57 ? -5.944  17.972 13.941  1.00 7.87  ? 1135 GLY G N    1 
ATOM   4082 C CA   . GLY G 1 57 ? -5.457  18.709 15.086  1.00 10.61 ? 1135 GLY G CA   1 
ATOM   4083 C C    . GLY G 1 57 ? -4.755  19.991 14.679  1.00 7.99  ? 1135 GLY G C    1 
ATOM   4084 O O    . GLY G 1 57 ? -4.808  20.418 13.537  1.00 6.44  ? 1135 GLY G O    1 
ATOM   4085 H H    . GLY G 1 57 ? -6.147  18.463 13.264  1.00 9.59  ? 1135 GLY G H    1 
ATOM   4086 H HA2  . GLY G 1 57 ? -6.201  18.937 15.665  1.00 12.88 ? 1135 GLY G HA2  1 
ATOM   4087 H HA3  . GLY G 1 57 ? -4.829  18.160 15.581  1.00 12.88 ? 1135 GLY G HA3  1 
ATOM   4088 N N    . VAL G 1 58 ? -4.080  20.586 15.654  1.00 6.98  ? 1136 VAL G N    1 
ATOM   4089 C CA   . VAL G 1 58 ? -3.371  21.850 15.476  1.00 9.69  ? 1136 VAL G CA   1 
ATOM   4090 C C    . VAL G 1 58 ? -1.980  21.570 14.902  1.00 5.48  ? 1136 VAL G C    1 
ATOM   4091 O O    . VAL G 1 58 ? -1.330  20.582 15.266  1.00 5.41  ? 1136 VAL G O    1 
ATOM   4092 C CB   . VAL G 1 58 ? -3.297  22.587 16.827  1.00 11.20 ? 1136 VAL G CB   1 
ATOM   4093 C CG1  . VAL G 1 58 ? -2.620  23.915 16.693  1.00 17.41 ? 1136 VAL G CG1  1 
ATOM   4094 C CG2  . VAL G 1 58 ? -4.700  22.772 17.398  1.00 11.79 ? 1136 VAL G CG2  1 
ATOM   4095 H H    . VAL G 1 58 ? -4.014  20.270 16.451  1.00 8.52  ? 1136 VAL G H    1 
ATOM   4096 H HA   . VAL G 1 58 ? -3.844  22.411 14.842  1.00 11.78 ? 1136 VAL G HA   1 
ATOM   4097 H HB   . VAL G 1 58 ? -2.771  22.049 17.438  1.00 13.59 ? 1136 VAL G HB   1 
ATOM   4098 H HG11 . VAL G 1 58 ? -2.611  24.353 17.558  1.00 21.04 ? 1136 VAL G HG11 1 
ATOM   4099 H HG12 . VAL G 1 58 ? -1.711  23.776 16.383  1.00 21.04 ? 1136 VAL G HG12 1 
ATOM   4100 H HG13 . VAL G 1 58 ? -3.108  24.455 16.053  1.00 21.04 ? 1136 VAL G HG13 1 
ATOM   4101 H HG21 . VAL G 1 58 ? -4.684  23.492 18.047  1.00 14.30 ? 1136 VAL G HG21 1 
ATOM   4102 H HG22 . VAL G 1 58 ? -5.308  22.992 16.675  1.00 14.30 ? 1136 VAL G HG22 1 
ATOM   4103 H HG23 . VAL G 1 58 ? -4.978  21.947 17.825  1.00 14.30 ? 1136 VAL G HG23 1 
ATOM   4104 N N    . PHE G 1 59 ? -1.532  22.420 13.990  1.00 7.13  ? 1137 PHE G N    1 
ATOM   4105 C CA   . PHE G 1 59 ? -0.252  22.189 13.335  1.00 9.16  ? 1137 PHE G CA   1 
ATOM   4106 C C    . PHE G 1 59 ? 0.435   23.539 13.053  1.00 8.32  ? 1137 PHE G C    1 
ATOM   4107 O O    . PHE G 1 59 ? -0.227  24.546 12.940  1.00 9.78  ? 1137 PHE G O    1 
ATOM   4108 C CB   . PHE G 1 59 ? -0.387  21.417 12.021  1.00 10.24 ? 1137 PHE G CB   1 
ATOM   4109 C CG   . PHE G 1 59 ? -1.183  22.123 10.985  1.00 9.93  ? 1137 PHE G CG   1 
ATOM   4110 C CD1  . PHE G 1 59 ? -2.561  22.049 10.996  1.00 8.91  ? 1137 PHE G CD1  1 
ATOM   4111 C CD2  . PHE G 1 59 ? -0.553  22.884 10.007  1.00 10.54 ? 1137 PHE G CD2  1 
ATOM   4112 C CE1  . PHE G 1 59 ? -3.300  22.705 10.053  1.00 9.14  ? 1137 PHE G CE1  1 
ATOM   4113 C CE2  . PHE G 1 59 ? -1.283  23.534 9.067   1.00 5.84  ? 1137 PHE G CE2  1 
ATOM   4114 C CZ   . PHE G 1 59 ? -2.655  23.447 9.084   1.00 7.93  ? 1137 PHE G CZ   1 
ATOM   4115 H H    . PHE G 1 59 ? -1.946  23.129 13.737  1.00 8.70  ? 1137 PHE G H    1 
ATOM   4116 H HA   . PHE G 1 59 ? 0.303   21.670 13.938  1.00 11.14 ? 1137 PHE G HA   1 
ATOM   4117 H HB2  . PHE G 1 59 ? 0.499   21.264 11.658  1.00 12.44 ? 1137 PHE G HB2  1 
ATOM   4118 H HB3  . PHE G 1 59 ? -0.823  20.570 12.201  1.00 12.44 ? 1137 PHE G HB3  1 
ATOM   4119 H HD1  . PHE G 1 59 ? -2.990  21.548 11.652  1.00 10.84 ? 1137 PHE G HD1  1 
ATOM   4120 H HD2  . PHE G 1 59 ? 0.375   22.947 9.997   1.00 12.79 ? 1137 PHE G HD2  1 
ATOM   4121 H HE1  . PHE G 1 59 ? -4.228  22.652 10.064  1.00 11.11 ? 1137 PHE G HE1  1 
ATOM   4122 H HE2  . PHE G 1 59 ? -0.856  24.039 8.412   1.00 7.15  ? 1137 PHE G HE2  1 
ATOM   4123 H HZ   . PHE G 1 59 ? -3.153  23.891 8.436   1.00 9.66  ? 1137 PHE G HZ   1 
ATOM   4124 N N    . PRO G 1 60 ? 1.772   23.504 12.924  1.00 11.86 ? 1138 PRO G N    1 
ATOM   4125 C CA   . PRO G 1 60 ? 2.501   24.770 12.698  1.00 10.79 ? 1138 PRO G CA   1 
ATOM   4126 C C    . PRO G 1 60 ? 2.391   25.183 11.240  1.00 10.72 ? 1138 PRO G C    1 
ATOM   4127 O O    . PRO G 1 60 ? 2.568   24.361 10.336  1.00 10.69 ? 1138 PRO G O    1 
ATOM   4128 C CB   . PRO G 1 60 ? 3.945   24.423 13.082  1.00 10.59 ? 1138 PRO G CB   1 
ATOM   4129 C CG   . PRO G 1 60 ? 4.040   22.898 13.001  1.00 11.35 ? 1138 PRO G CG   1 
ATOM   4130 C CD   . PRO G 1 60 ? 2.642   22.337 12.830  1.00 10.60 ? 1138 PRO G CD   1 
ATOM   4131 H HA   . PRO G 1 60 ? 2.173   25.481 13.271  1.00 13.09 ? 1138 PRO G HA   1 
ATOM   4132 H HB2  . PRO G 1 60 ? 4.559   24.840 12.458  1.00 12.85 ? 1138 PRO G HB2  1 
ATOM   4133 H HB3  . PRO G 1 60 ? 4.128   24.732 13.983  1.00 12.85 ? 1138 PRO G HB3  1 
ATOM   4134 H HG2  . PRO G 1 60 ? 4.592   22.656 12.241  1.00 13.76 ? 1138 PRO G HG2  1 
ATOM   4135 H HG3  . PRO G 1 60 ? 4.437   22.562 13.820  1.00 13.76 ? 1138 PRO G HG3  1 
ATOM   4136 H HD2  . PRO G 1 60 ? 2.549   21.910 11.964  1.00 12.87 ? 1138 PRO G HD2  1 
ATOM   4137 H HD3  . PRO G 1 60 ? 2.441   21.702 13.535  1.00 12.87 ? 1138 PRO G HD3  1 
ATOM   4138 N N    . VAL G 1 61 ? 2.067   26.460 11.022  1.00 10.28 ? 1139 VAL G N    1 
ATOM   4139 C CA   . VAL G 1 61 ? 1.911   26.988 9.662   1.00 15.66 ? 1139 VAL G CA   1 
ATOM   4140 C C    . VAL G 1 61 ? 3.237   26.950 8.901   1.00 14.55 ? 1139 VAL G C    1 
ATOM   4141 O O    . VAL G 1 61 ? 3.259   26.762 7.681   1.00 11.77 ? 1139 VAL G O    1 
ATOM   4142 C CB   . VAL G 1 61 ? 1.340   28.416 9.753   1.00 19.69 ? 1139 VAL G CB   1 
ATOM   4143 C CG1  . VAL G 1 61 ? 1.349   29.137 8.395   1.00 19.72 ? 1139 VAL G CG1  1 
ATOM   4144 C CG2  . VAL G 1 61 ? -0.089  28.376 10.358  1.00 20.81 ? 1139 VAL G CG2  1 
ATOM   4145 H H    . VAL G 1 61 ? 1.933   27.041 11.641  1.00 12.49 ? 1139 VAL G H    1 
ATOM   4146 H HA   . VAL G 1 61 ? 1.289   26.432 9.168   1.00 18.94 ? 1139 VAL G HA   1 
ATOM   4147 H HB   . VAL G 1 61 ? 1.914   28.935 10.338  1.00 23.77 ? 1139 VAL G HB   1 
ATOM   4148 H HG11 . VAL G 1 61 ? 0.767   29.911 8.445   1.00 23.81 ? 1139 VAL G HG11 1 
ATOM   4149 H HG12 . VAL G 1 61 ? 2.255   29.417 8.192   1.00 23.81 ? 1139 VAL G HG12 1 
ATOM   4150 H HG13 . VAL G 1 61 ? 1.030   28.527 7.712   1.00 23.81 ? 1139 VAL G HG13 1 
ATOM   4151 H HG21 . VAL G 1 61 ? -0.502  29.247 10.250  1.00 25.12 ? 1139 VAL G HG21 1 
ATOM   4152 H HG22 . VAL G 1 61 ? -0.610  27.702 9.894   1.00 25.12 ? 1139 VAL G HG22 1 
ATOM   4153 H HG23 . VAL G 1 61 ? -0.026  28.154 11.300  1.00 25.12 ? 1139 VAL G HG23 1 
ATOM   4154 N N    . SER G 1 62 ? 4.352   27.110 9.605   1.00 9.78  ? 1140 SER G N    1 
ATOM   4155 C CA   . SER G 1 62 ? 5.643   27.083 8.948   1.00 16.16 ? 1140 SER G CA   1 
ATOM   4156 C C    . SER G 1 62 ? 5.991   25.697 8.434   1.00 15.11 ? 1140 SER G C    1 
ATOM   4157 O O    . SER G 1 62 ? 6.980   25.568 7.719   1.00 12.54 ? 1140 SER G O    1 
ATOM   4158 C CB   . SER G 1 62 ? 6.736   27.559 9.899   1.00 17.44 ? 1140 SER G CB   1 
ATOM   4159 O OG   . SER G 1 62 ? 6.821   26.716 11.026  1.00 14.93 ? 1140 SER G OG   1 
ATOM   4160 H H    . SER G 1 62 ? 4.383   27.234 10.456  1.00 11.88 ? 1140 SER G H    1 
ATOM   4161 H HA   . SER G 1 62 ? 5.622   27.697 8.197   1.00 19.54 ? 1140 SER G HA   1 
ATOM   4162 H HB2  . SER G 1 62 ? 7.587   27.550 9.433   1.00 21.08 ? 1140 SER G HB2  1 
ATOM   4163 H HB3  . SER G 1 62 ? 6.529   28.460 10.194  1.00 21.08 ? 1140 SER G HB3  1 
ATOM   4164 H HG   . SER G 1 62 ? 6.103   26.745 11.461  1.00 18.06 ? 1140 SER G HG   1 
ATOM   4165 N N    . PHE G 1 63 ? 5.213   24.659 8.755   1.00 11.42 ? 1141 PHE G N    1 
ATOM   4166 C CA   . PHE G 1 63 ? 5.504   23.325 8.244   1.00 7.26  ? 1141 PHE G CA   1 
ATOM   4167 C C    . PHE G 1 63 ? 4.682   22.984 7.008   1.00 7.26  ? 1141 PHE G C    1 
ATOM   4168 O O    . PHE G 1 63 ? 4.680   21.819 6.573   1.00 9.65  ? 1141 PHE G O    1 
ATOM   4169 C CB   . PHE G 1 63 ? 5.262   22.251 9.292   1.00 10.12 ? 1141 PHE G CB   1 
ATOM   4170 C CG   . PHE G 1 63 ? 6.322   22.143 10.333  1.00 11.90 ? 1141 PHE G CG   1 
ATOM   4171 C CD1  . PHE G 1 63 ? 6.859   23.269 10.924  1.00 19.79 ? 1141 PHE G CD1  1 
ATOM   4172 C CD2  . PHE G 1 63 ? 6.742   20.891 10.768  1.00 16.32 ? 1141 PHE G CD2  1 
ATOM   4173 C CE1  . PHE G 1 63 ? 7.829   23.135 11.928  1.00 19.85 ? 1141 PHE G CE1  1 
ATOM   4174 C CE2  . PHE G 1 63 ? 7.711   20.751 11.756  1.00 13.45 ? 1141 PHE G CE2  1 
ATOM   4175 C CZ   . PHE G 1 63 ? 8.235   21.876 12.346  1.00 14.90 ? 1141 PHE G CZ   1 
ATOM   4176 H H    . PHE G 1 63 ? 4.520   24.706 9.263   1.00 13.85 ? 1141 PHE G H    1 
ATOM   4177 H HA   . PHE G 1 63 ? 6.448   23.311 8.019   1.00 8.86  ? 1141 PHE G HA   1 
ATOM   4178 H HB2  . PHE G 1 63 ? 4.427   22.446 9.745   1.00 12.29 ? 1141 PHE G HB2  1 
ATOM   4179 H HB3  . PHE G 1 63 ? 5.204   21.392 8.845   1.00 12.29 ? 1141 PHE G HB3  1 
ATOM   4180 H HD1  . PHE G 1 63 ? 6.579   24.115 10.656  1.00 23.90 ? 1141 PHE G HD1  1 
ATOM   4181 H HD2  . PHE G 1 63 ? 6.366   20.129 10.389  1.00 19.73 ? 1141 PHE G HD2  1 
ATOM   4182 H HE1  . PHE G 1 63 ? 8.201   23.894 12.316  1.00 23.97 ? 1141 PHE G HE1  1 
ATOM   4183 H HE2  . PHE G 1 63 ? 8.001   19.906 12.015  1.00 16.29 ? 1141 PHE G HE2  1 
ATOM   4184 H HZ   . PHE G 1 63 ? 8.864   21.794 13.026  1.00 18.03 ? 1141 PHE G HZ   1 
ATOM   4185 N N    . VAL G 1 64 ? 3.970   23.943 6.441   1.00 8.41  ? 1142 VAL G N    1 
ATOM   4186 C CA   . VAL G 1 64 ? 3.144   23.644 5.280   1.00 11.77 ? 1142 VAL G CA   1 
ATOM   4187 C C    . VAL G 1 64 ? 3.317   24.689 4.204   1.00 8.82  ? 1142 VAL G C    1 
ATOM   4188 O O    . VAL G 1 64 ? 3.706   25.826 4.455   1.00 11.78 ? 1142 VAL G O    1 
ATOM   4189 C CB   . VAL G 1 64 ? 1.645   23.535 5.641   1.00 6.57  ? 1142 VAL G CB   1 
ATOM   4190 C CG1  . VAL G 1 64 ? 1.504   22.663 6.872   1.00 11.05 ? 1142 VAL G CG1  1 
ATOM   4191 C CG2  . VAL G 1 64 ? 1.093   24.898 5.874   1.00 9.51  ? 1142 VAL G CG2  1 
ATOM   4192 H H    . VAL G 1 64 ? 3.949   24.761 6.705   1.00 10.24 ? 1142 VAL G H    1 
ATOM   4193 H HA   . VAL G 1 64 ? 3.458   22.800 4.918   1.00 14.27 ? 1142 VAL G HA   1 
ATOM   4194 H HB   . VAL G 1 64 ? 1.140   23.131 4.918   1.00 8.03  ? 1142 VAL G HB   1 
ATOM   4195 H HG11 . VAL G 1 64 ? 0.563   22.494 7.033   1.00 13.41 ? 1142 VAL G HG11 1 
ATOM   4196 H HG12 . VAL G 1 64 ? 1.970   21.825 6.720   1.00 13.41 ? 1142 VAL G HG12 1 
ATOM   4197 H HG13 . VAL G 1 64 ? 1.892   23.124 7.632   1.00 13.41 ? 1142 VAL G HG13 1 
ATOM   4198 H HG21 . VAL G 1 64 ? 0.291   24.826 6.415   1.00 11.56 ? 1142 VAL G HG21 1 
ATOM   4199 H HG22 . VAL G 1 64 ? 1.757   25.433 6.336   1.00 11.56 ? 1142 VAL G HG22 1 
ATOM   4200 H HG23 . VAL G 1 64 ? 0.879   25.303 5.019   1.00 11.56 ? 1142 VAL G HG23 1 
ATOM   4201 N N    . HIS G 1 65 ? 2.968   24.291 2.996   1.00 9.89  ? 1143 HIS G N    1 
ATOM   4202 C CA   . HIS G 1 65 ? 2.876   25.207 1.875   1.00 17.13 ? 1143 HIS G CA   1 
ATOM   4203 C C    . HIS G 1 65 ? 1.411   25.386 1.505   1.00 17.66 ? 1143 HIS G C    1 
ATOM   4204 O O    . HIS G 1 65 ? 0.689   24.400 1.375   1.00 11.71 ? 1143 HIS G O    1 
ATOM   4205 C CB   . HIS G 1 65 ? 3.652   24.666 0.667   1.00 14.36 ? 1143 HIS G CB   1 
ATOM   4206 C CG   . HIS G 1 65 ? 5.092   25.070 0.631   1.00 29.04 ? 1143 HIS G CG   1 
ATOM   4207 N ND1  . HIS G 1 65 ? 6.001   24.487 -0.226  1.00 29.65 ? 1143 HIS G ND1  1 
ATOM   4208 C CD2  . HIS G 1 65 ? 5.783   25.997 1.337   1.00 37.78 ? 1143 HIS G CD2  1 
ATOM   4209 C CE1  . HIS G 1 65 ? 7.185   25.051 -0.060  1.00 28.20 ? 1143 HIS G CE1  1 
ATOM   4210 N NE2  . HIS G 1 65 ? 7.081   25.965 0.888   1.00 27.01 ? 1143 HIS G NE2  1 
ATOM   4211 H H    . HIS G 1 65 ? 2.776   23.477 2.796   1.00 12.02 ? 1143 HIS G H    1 
ATOM   4212 H HA   . HIS G 1 65 ? 3.246   26.069 2.122   1.00 20.70 ? 1143 HIS G HA   1 
ATOM   4213 H HB2  . HIS G 1 65 ? 3.619   23.697 0.687   1.00 17.38 ? 1143 HIS G HB2  1 
ATOM   4214 H HB3  . HIS G 1 65 ? 3.234   24.996 -0.143  1.00 17.38 ? 1143 HIS G HB3  1 
ATOM   4215 H HD2  . HIS G 1 65 ? 5.442   26.552 2.001   1.00 45.48 ? 1143 HIS G HD2  1 
ATOM   4216 H HE1  . HIS G 1 65 ? 7.959   24.841 -0.531  1.00 33.98 ? 1143 HIS G HE1  1 
ATOM   4217 H HE2  . HIS G 1 65 ? 7.723   26.459 1.177   1.00 32.56 ? 1143 HIS G HE2  1 
ATOM   4218 N N    . ILE G 1 66 ? 0.994   26.633 1.292   1.00 18.58 ? 1144 ILE G N    1 
ATOM   4219 C CA   . ILE G 1 66 ? -0.377  26.900 0.871   1.00 21.56 ? 1144 ILE G CA   1 
ATOM   4220 C C    . ILE G 1 66 ? -0.610  26.333 -0.518  1.00 21.85 ? 1144 ILE G C    1 
ATOM   4221 O O    . ILE G 1 66 ? 0.164   26.587 -1.449  1.00 21.78 ? 1144 ILE G O    1 
ATOM   4222 C CB   . ILE G 1 66 ? -0.675  28.405 0.902   1.00 19.22 ? 1144 ILE G CB   1 
ATOM   4223 C CG1  . ILE G 1 66 ? -0.694  28.885 2.346   1.00 23.66 ? 1144 ILE G CG1  1 
ATOM   4224 C CG2  . ILE G 1 66 ? -2.018  28.684 0.226   1.00 24.43 ? 1144 ILE G CG2  1 
ATOM   4225 C CD1  . ILE G 1 66 ? 0.079   30.150 2.597   1.00 33.11 ? 1144 ILE G CD1  1 
ATOM   4226 H H    . ILE G 1 66 ? 1.482   27.335 1.384   1.00 22.44 ? 1144 ILE G H    1 
ATOM   4227 H HA   . ILE G 1 66 ? -0.977  26.455 1.490   1.00 26.02 ? 1144 ILE G HA   1 
ATOM   4228 H HB   . ILE G 1 66 ? 0.019   28.881 0.420   1.00 23.21 ? 1144 ILE G HB   1 
ATOM   4229 H HG12 . ILE G 1 66 ? -1.615  29.050 2.604   1.00 28.53 ? 1144 ILE G HG12 1 
ATOM   4230 H HG13 . ILE G 1 66 ? -0.311  28.193 2.907   1.00 28.53 ? 1144 ILE G HG13 1 
ATOM   4231 H HG21 . ILE G 1 66 ? -2.207  29.634 0.278   1.00 29.46 ? 1144 ILE G HG21 1 
ATOM   4232 H HG22 . ILE G 1 66 ? -1.969  28.406 -0.702  1.00 29.46 ? 1144 ILE G HG22 1 
ATOM   4233 H HG23 . ILE G 1 66 ? -2.712  28.184 0.684   1.00 29.46 ? 1144 ILE G HG23 1 
ATOM   4234 H HD11 . ILE G 1 66 ? 0.004   30.385 3.535   1.00 39.88 ? 1144 ILE G HD11 1 
ATOM   4235 H HD12 . ILE G 1 66 ? 1.010   30.003 2.366   1.00 39.88 ? 1144 ILE G HD12 1 
ATOM   4236 H HD13 . ILE G 1 66 ? -0.289  30.860 2.048   1.00 39.88 ? 1144 ILE G HD13 1 
ATOM   4237 N N    . LEU G 1 67 ? -1.710  25.607 -0.680  1.00 18.61 ? 1145 LEU G N    1 
ATOM   4238 C CA   . LEU G 1 67 ? -2.067  25.034 -1.965  1.00 22.88 ? 1145 LEU G CA   1 
ATOM   4239 C C    . LEU G 1 67 ? -3.320  25.662 -2.550  1.00 29.95 ? 1145 LEU G C    1 
ATOM   4240 O O    . LEU G 1 67 ? -3.282  26.160 -3.672  1.00 33.17 ? 1145 LEU G O    1 
ATOM   4241 C CB   . LEU G 1 67 ? -2.292  23.529 -1.823  1.00 19.81 ? 1145 LEU G CB   1 
ATOM   4242 C CG   . LEU G 1 67 ? -1.172  22.504 -1.865  1.00 22.24 ? 1145 LEU G CG   1 
ATOM   4243 C CD1  . LEU G 1 67 ? -1.911  21.163 -1.827  1.00 18.13 ? 1145 LEU G CD1  1 
ATOM   4244 C CD2  . LEU G 1 67 ? -0.362  22.652 -3.084  1.00 22.48 ? 1145 LEU G CD2  1 
ATOM   4245 H H    . LEU G 1 67 ? -2.269  25.432 -0.050  1.00 22.48 ? 1145 LEU G H    1 
ATOM   4246 H HA   . LEU G 1 67 ? -1.329  25.192 -2.574  1.00 27.60 ? 1145 LEU G HA   1 
ATOM   4247 H HB2  . LEU G 1 67 ? -2.724  23.398 -0.965  1.00 23.92 ? 1145 LEU G HB2  1 
ATOM   4248 H HB3  . LEU G 1 67 ? -2.895  23.275 -2.540  1.00 23.92 ? 1145 LEU G HB3  1 
ATOM   4249 H HG   . LEU G 1 67 ? -0.537  22.591 -1.137  1.00 26.83 ? 1145 LEU G HG   1 
ATOM   4250 H HD11 . LEU G 1 67 ? -1.260  20.444 -1.810  1.00 21.91 ? 1145 LEU G HD11 1 
ATOM   4251 H HD12 . LEU G 1 67 ? -2.462  21.129 -1.029  1.00 21.91 ? 1145 LEU G HD12 1 
ATOM   4252 H HD13 . LEU G 1 67 ? -2.468  21.086 -2.617  1.00 21.91 ? 1145 LEU G HD13 1 
ATOM   4253 H HD21 . LEU G 1 67 ? 0.273   21.920 -3.132  1.00 27.12 ? 1145 LEU G HD21 1 
ATOM   4254 H HD22 . LEU G 1 67 ? -0.947  22.632 -3.857  1.00 27.12 ? 1145 LEU G HD22 1 
ATOM   4255 H HD23 . LEU G 1 67 ? 0.111   23.498 -3.049  1.00 27.12 ? 1145 LEU G HD23 1 
ATOM   4256 N N    . SER G 1 68 ? -4.420  25.658 -1.803  1.00 34.92 ? 1146 SER G N    1 
ATOM   4257 C CA   . SER G 1 68 ? -5.719  26.137 -2.255  1.00 24.37 ? 1146 SER G CA   1 
ATOM   4258 C C    . SER G 1 68 ? -6.255  27.143 -1.259  1.00 28.15 ? 1146 SER G C    1 
ATOM   4259 O O    . SER G 1 68 ? -6.201  26.887 -0.057  1.00 30.18 ? 1146 SER G O    1 
ATOM   4260 C CB   . SER G 1 68 ? -6.709  24.972 -2.409  1.00 22.67 ? 1146 SER G CB   1 
ATOM   4261 O OG   . SER G 1 68 ? -6.237  23.954 -3.297  1.00 20.08 ? 1146 SER G OG   1 
ATOM   4262 H H    . SER G 1 68 ? -4.440  25.369 -0.993  1.00 42.05 ? 1146 SER G H    1 
ATOM   4263 H HA   . SER G 1 68 ? -5.631  26.559 -3.124  1.00 29.39 ? 1146 SER G HA   1 
ATOM   4264 H HB2  . SER G 1 68 ? -6.855  24.575 -1.536  1.00 27.35 ? 1146 SER G HB2  1 
ATOM   4265 H HB3  . SER G 1 68 ? -7.543  25.322 -2.758  1.00 27.35 ? 1146 SER G HB3  1 
ATOM   4266 H HG   . SER G 1 68 ? -6.148  24.267 -4.071  1.00 24.24 ? 1146 SER G HG   1 
ATOM   4267 N N    . ILE H 2 2  ? 13.475  22.848 9.971   1.00 40.09 ? 1700 ILE H N    1 
ATOM   4268 C CA   . ILE H 2 2  ? 13.436  23.986 10.881  1.00 39.20 ? 1700 ILE H CA   1 
ATOM   4269 C C    . ILE H 2 2  ? 12.943  23.569 12.282  1.00 46.26 ? 1700 ILE H C    1 
ATOM   4270 O O    . ILE H 2 2  ? 12.667  22.389 12.556  1.00 40.80 ? 1700 ILE H O    1 
ATOM   4271 C CB   . ILE H 2 2  ? 12.546  25.126 10.318  1.00 44.11 ? 1700 ILE H CB   1 
ATOM   4272 C CG1  . ILE H 2 2  ? 11.137  24.602 10.005  1.00 37.99 ? 1700 ILE H CG1  1 
ATOM   4273 C CG2  . ILE H 2 2  ? 13.187  25.767 9.083   1.00 47.35 ? 1700 ILE H CG2  1 
ATOM   4274 C CD1  . ILE H 2 2  ? 10.304  25.501 9.075   1.00 30.97 ? 1700 ILE H CD1  1 
ATOM   4275 H HA   . ILE H 2 2  ? 14.342  24.319 10.972  1.00 47.18 ? 1700 ILE H HA   1 
ATOM   4276 H HB   . ILE H 2 2  ? 12.470  25.814 10.998  1.00 53.08 ? 1700 ILE H HB   1 
ATOM   4277 H HG12 . ILE H 2 2  ? 11.219  23.735 9.577   1.00 45.73 ? 1700 ILE H HG12 1 
ATOM   4278 H HG13 . ILE H 2 2  ? 10.649  24.514 10.839  1.00 45.73 ? 1700 ILE H HG13 1 
ATOM   4279 H HG21 . ILE H 2 2  ? 12.621  26.492 8.774   1.00 56.97 ? 1700 ILE H HG21 1 
ATOM   4280 H HG22 . ILE H 2 2  ? 14.062  26.110 9.323   1.00 56.97 ? 1700 ILE H HG22 1 
ATOM   4281 H HG23 . ILE H 2 2  ? 13.274  25.096 8.388   1.00 56.97 ? 1700 ILE H HG23 1 
ATOM   4282 H HD11 . ILE H 2 2  ? 9.431   25.098 8.945   1.00 37.32 ? 1700 ILE H HD11 1 
ATOM   4283 H HD12 . ILE H 2 2  ? 10.207  26.375 9.484   1.00 37.32 ? 1700 ILE H HD12 1 
ATOM   4284 H HD13 . ILE H 2 2  ? 10.760  25.583 8.223   1.00 37.32 ? 1700 ILE H HD13 1 
ATOM   4285 N N    . LYS H 2 3  ? 12.857  24.569 13.155  1.00 41.80 ? 1701 LYS H N    1 
ATOM   4286 C CA   . LYS H 2 3  ? 12.410  24.425 14.529  1.00 31.08 ? 1701 LYS H CA   1 
ATOM   4287 C C    . LYS H 2 3  ? 10.921  24.750 14.620  1.00 29.83 ? 1701 LYS H C    1 
ATOM   4288 O O    . LYS H 2 3  ? 10.438  25.714 14.015  1.00 26.01 ? 1701 LYS H O    1 
ATOM   4289 C CB   . LYS H 2 3  ? 13.217  25.342 15.458  1.00 41.36 ? 1701 LYS H CB   1 
ATOM   4290 C CG   . LYS H 2 3  ? 14.728  25.340 15.193  1.00 51.72 ? 1701 LYS H CG   1 
ATOM   4291 C CD   . LYS H 2 3  ? 15.471  26.366 16.063  1.00 63.00 ? 1701 LYS H CD   1 
ATOM   4292 C CE   . LYS H 2 3  ? 16.942  25.971 16.257  1.00 58.18 ? 1701 LYS H CE   1 
ATOM   4293 N NZ   . LYS H 2 3  ? 17.441  26.171 17.654  1.00 56.85 ? 1701 LYS H NZ   1 
ATOM   4294 H H    . LYS H 2 3  ? 13.064  25.381 12.961  1.00 50.31 ? 1701 LYS H H    1 
ATOM   4295 H HA   . LYS H 2 3  ? 12.538  23.511 14.827  1.00 37.44 ? 1701 LYS H HA   1 
ATOM   4296 H HB2  . LYS H 2 3  ? 12.900  26.252 15.347  1.00 49.78 ? 1701 LYS H HB2  1 
ATOM   4297 H HB3  . LYS H 2 3  ? 13.079  25.053 16.374  1.00 49.78 ? 1701 LYS H HB3  1 
ATOM   4298 H HG2  . LYS H 2 3  ? 15.085  24.461 15.392  1.00 62.21 ? 1701 LYS H HG2  1 
ATOM   4299 H HG3  . LYS H 2 3  ? 14.888  25.561 14.262  1.00 62.21 ? 1701 LYS H HG3  1 
ATOM   4300 H HD2  . LYS H 2 3  ? 15.443  27.235 15.632  1.00 75.75 ? 1701 LYS H HD2  1 
ATOM   4301 H HD3  . LYS H 2 3  ? 15.050  26.414 16.935  1.00 75.75 ? 1701 LYS H HD3  1 
ATOM   4302 H HE2  . LYS H 2 3  ? 17.044  25.032 16.038  1.00 69.96 ? 1701 LYS H HE2  1 
ATOM   4303 H HE3  . LYS H 2 3  ? 17.490  26.511 15.667  1.00 69.96 ? 1701 LYS H HE3  1 
ATOM   4304 H HZ1  . LYS H 2 3  ? 18.296  25.929 17.710  1.00 68.37 ? 1701 LYS H HZ1  1 
ATOM   4305 H HZ2  . LYS H 2 3  ? 17.369  27.028 17.884  1.00 68.37 ? 1701 LYS H HZ2  1 
ATOM   4306 H HZ3  . LYS H 2 3  ? 16.964  25.679 18.222  1.00 68.37 ? 1701 LYS H HZ3  1 
ATOM   4307 N N    . LYS H 2 4  ? 10.208  23.956 15.393  1.00 25.47 ? 1702 LYS H N    1 
ATOM   4308 C CA   . LYS H 2 4  ? 8.779   24.156 15.583  1.00 31.26 ? 1702 LYS H CA   1 
ATOM   4309 C C    . LYS H 2 4  ? 8.539   25.355 16.501  1.00 24.72 ? 1702 LYS H C    1 
ATOM   4310 O O    . LYS H 2 4  ? 9.163   25.456 17.556  1.00 33.18 ? 1702 LYS H O    1 
ATOM   4311 C CB   . LYS H 2 4  ? 8.188   22.883 16.178  1.00 25.84 ? 1702 LYS H CB   1 
ATOM   4312 C CG   . LYS H 2 4  ? 6.768   22.963 16.602  1.00 24.90 ? 1702 LYS H CG   1 
ATOM   4313 C CD   . LYS H 2 4  ? 6.247   21.595 17.038  1.00 13.99 ? 1702 LYS H CD   1 
ATOM   4314 C CE   . LYS H 2 4  ? 6.642   20.460 16.113  1.00 14.26 ? 1702 LYS H CE   1 
ATOM   4315 N NZ   . LYS H 2 4  ? 5.988   19.202 16.523  1.00 15.05 ? 1702 LYS H NZ   1 
ATOM   4316 H H    . LYS H 2 4  ? 10.527  23.286 15.826  1.00 30.71 ? 1702 LYS H H    1 
ATOM   4317 H HA   . LYS H 2 4  ? 8.334   24.347 14.742  1.00 37.66 ? 1702 LYS H HA   1 
ATOM   4318 H HB2  . LYS H 2 4  ? 8.249   22.181 15.512  1.00 31.16 ? 1702 LYS H HB2  1 
ATOM   4319 H HB3  . LYS H 2 4  ? 8.708   22.645 16.961  1.00 31.16 ? 1702 LYS H HB3  1 
ATOM   4320 H HG2  . LYS H 2 4  ? 6.688   23.574 17.352  1.00 30.03 ? 1702 LYS H HG2  1 
ATOM   4321 H HG3  . LYS H 2 4  ? 6.226   23.275 15.861  1.00 30.03 ? 1702 LYS H HG3  1 
ATOM   4322 H HD2  . LYS H 2 4  ? 6.601   21.393 17.918  1.00 16.94 ? 1702 LYS H HD2  1 
ATOM   4323 H HD3  . LYS H 2 4  ? 5.278   21.626 17.069  1.00 16.94 ? 1702 LYS H HD3  1 
ATOM   4324 H HE2  . LYS H 2 4  ? 6.367   20.670 15.207  1.00 17.26 ? 1702 LYS H HE2  1 
ATOM   4325 H HE3  . LYS H 2 4  ? 7.603   20.334 16.147  1.00 17.26 ? 1702 LYS H HE3  1 
ATOM   4326 H HZ1  . LYS H 2 4  ? 6.226   18.543 15.974  1.00 18.20 ? 1702 LYS H HZ1  1 
ATOM   4327 H HZ2  . LYS H 2 4  ? 6.232   18.989 17.352  1.00 18.20 ? 1702 LYS H HZ2  1 
ATOM   4328 H HZ3  . LYS H 2 4  ? 5.104   19.296 16.496  1.00 18.20 ? 1702 LYS H HZ3  1 
ATOM   4329 N N    . PRO H 2 5  ? 7.692   26.306 16.116  1.00 26.08 ? 1703 PRO H N    1 
ATOM   4330 C CA   . PRO H 2 5  ? 7.358   27.404 17.030  1.00 29.40 ? 1703 PRO H CA   1 
ATOM   4331 C C    . PRO H 2 5  ? 6.660   26.874 18.273  1.00 35.01 ? 1703 PRO H C    1 
ATOM   4332 O O    . PRO H 2 5  ? 6.085   25.786 18.267  1.00 30.23 ? 1703 PRO H O    1 
ATOM   4333 C CB   . PRO H 2 5  ? 6.406   28.281 16.203  1.00 34.55 ? 1703 PRO H CB   1 
ATOM   4334 C CG   . PRO H 2 5  ? 5.774   27.304 15.206  1.00 30.11 ? 1703 PRO H CG   1 
ATOM   4335 C CD   . PRO H 2 5  ? 6.950   26.403 14.849  1.00 22.49 ? 1703 PRO H CD   1 
ATOM   4336 H HA   . PRO H 2 5  ? 8.147   27.913 17.274  1.00 35.43 ? 1703 PRO H HA   1 
ATOM   4337 H HB2  . PRO H 2 5  ? 5.734   28.680 16.778  1.00 41.61 ? 1703 PRO H HB2  1 
ATOM   4338 H HB3  . PRO H 2 5  ? 6.905   28.976 15.745  1.00 41.61 ? 1703 PRO H HB3  1 
ATOM   4339 H HG2  . PRO H 2 5  ? 5.056   26.804 15.626  1.00 36.28 ? 1703 PRO H HG2  1 
ATOM   4340 H HG3  . PRO H 2 5  ? 5.437   27.777 14.429  1.00 36.28 ? 1703 PRO H HG3  1 
ATOM   4341 H HD2  . PRO H 2 5  ? 6.642   25.530 14.561  1.00 27.14 ? 1703 PRO H HD2  1 
ATOM   4342 H HD3  . PRO H 2 5  ? 7.497   26.807 14.157  1.00 27.14 ? 1703 PRO H HD3  1 
ATOM   4343 N N    . VAL H 2 6  ? 6.715   27.656 19.358  1.00 41.69 ? 1704 VAL H N    1 
ATOM   4344 C CA   . VAL H 2 6  ? 6.099   27.231 20.614  1.00 41.43 ? 1704 VAL H CA   1 
ATOM   4345 C C    . VAL H 2 6  ? 4.600   27.483 20.527  1.00 37.58 ? 1704 VAL H C    1 
ATOM   4346 O O    . VAL H 2 6  ? 4.145   28.406 19.830  1.00 33.05 ? 1704 VAL H O    1 
ATOM   4347 C CB   . VAL H 2 6  ? 6.705   27.955 21.837  1.00 43.18 ? 1704 VAL H CB   1 
ATOM   4348 C CG1  . VAL H 2 6  ? 8.093   27.369 22.193  1.00 40.89 ? 1704 VAL H CG1  1 
ATOM   4349 C CG2  . VAL H 2 6  ? 6.746   29.463 21.594  1.00 46.53 ? 1704 VAL H CG2  1 
ATOM   4350 H H    . VAL H 2 6  ? 7.099   28.425 19.389  1.00 50.17 ? 1704 VAL H H    1 
ATOM   4351 H HA   . VAL H 2 6  ? 6.269   26.283 20.730  1.00 49.86 ? 1704 VAL H HA   1 
ATOM   4352 H HB   . VAL H 2 6  ? 6.142   27.809 22.612  1.00 51.96 ? 1704 VAL H HB   1 
ATOM   4353 H HG11 . VAL H 2 6  ? 8.449   27.844 22.959  1.00 49.22 ? 1704 VAL H HG11 1 
ATOM   4354 H HG12 . VAL H 2 6  ? 7.993   26.427 22.405  1.00 49.22 ? 1704 VAL H HG12 1 
ATOM   4355 H HG13 . VAL H 2 6  ? 8.685   27.475 21.432  1.00 49.22 ? 1704 VAL H HG13 1 
ATOM   4356 H HG21 . VAL H 2 6  ? 7.116   29.899 22.377  1.00 55.99 ? 1704 VAL H HG21 1 
ATOM   4357 H HG22 . VAL H 2 6  ? 7.304   29.644 20.821  1.00 55.99 ? 1704 VAL H HG22 1 
ATOM   4358 H HG23 . VAL H 2 6  ? 5.844   29.781 21.432  1.00 55.99 ? 1704 VAL H HG23 1 
ATOM   4359 N N    . ARG H 2 7  ? 3.822   26.662 21.244  1.00 33.57 ? 1705 ARG H N    1 
ATOM   4360 C CA   . ARG H 2 7  ? 2.400   26.932 21.399  1.00 35.30 ? 1705 ARG H CA   1 
ATOM   4361 C C    . ARG H 2 7  ? 2.245   28.073 22.398  1.00 33.97 ? 1705 ARG H C    1 
ATOM   4362 O O    . ARG H 2 7  ? 2.912   28.087 23.439  1.00 40.26 ? 1705 ARG H O    1 
ATOM   4363 C CB   . ARG H 2 7  ? 1.654   25.699 21.918  1.00 28.38 ? 1705 ARG H CB   1 
ATOM   4364 C CG   . ARG H 2 7  ? 1.678   24.471 21.041  1.00 15.46 ? 1705 ARG H CG   1 
ATOM   4365 C CD   . ARG H 2 7  ? 0.656   24.548 19.893  1.00 16.50 ? 1705 ARG H CD   1 
ATOM   4366 N NE   . ARG H 2 7  ? -0.729  24.716 20.313  1.00 13.36 ? 1705 ARG H NE   1 
ATOM   4367 C CZ   . ARG H 2 7  ? -1.551  23.722 20.608  1.00 11.80 ? 1705 ARG H CZ   1 
ATOM   4368 N NH1  . ARG H 2 7  ? -1.119  22.481 20.729  1.00 14.96 ? 1705 ARG H NH1  1 
ATOM   4369 N NH2  . ARG H 2 7  ? -2.829  23.986 20.832  1.00 14.25 ? 1705 ARG H NH2  1 
ATOM   4370 H H    . ARG H 2 7  ? 4.097   25.951 21.643  1.00 40.42 ? 1705 ARG H H    1 
ATOM   4371 H HA   . ARG H 2 7  ? 2.014   27.171 20.542  1.00 42.51 ? 1705 ARG H HA   1 
ATOM   4372 H HB2  . ARG H 2 7  ? 2.046   25.447 22.768  1.00 34.20 ? 1705 ARG H HB2  1 
ATOM   4373 H HB3  . ARG H 2 7  ? 0.723   25.941 22.040  1.00 34.20 ? 1705 ARG H HB3  1 
ATOM   4374 H HG2  . ARG H 2 7  ? 2.561   24.376 20.651  1.00 18.70 ? 1705 ARG H HG2  1 
ATOM   4375 H HG3  . ARG H 2 7  ? 1.467   23.692 21.579  1.00 18.70 ? 1705 ARG H HG3  1 
ATOM   4376 H HD2  . ARG H 2 7  ? 0.882   25.305 19.330  1.00 19.95 ? 1705 ARG H HD2  1 
ATOM   4377 H HD3  . ARG H 2 7  ? 0.706   23.726 19.380  1.00 19.95 ? 1705 ARG H HD3  1 
ATOM   4378 H HE   . ARG H 2 7  ? -1.034  25.518 20.373  1.00 16.18 ? 1705 ARG H HE   1 
ATOM   4379 H HH11 . ARG H 2 7  ? -0.285  22.302 20.615  1.00 18.09 ? 1705 ARG H HH11 1 
ATOM   4380 H HH12 . ARG H 2 7  ? -1.671  21.850 20.921  1.00 18.09 ? 1705 ARG H HH12 1 
ATOM   4381 H HH21 . ARG H 2 7  ? -3.115  24.796 20.784  1.00 17.25 ? 1705 ARG H HH21 1 
ATOM   4382 H HH22 . ARG H 2 7  ? -3.373  23.349 21.024  1.00 17.25 ? 1705 ARG H HH22 1 
ATOM   4383 N N    . ARG H 2 8  ? 1.411   29.050 22.067  1.00 36.69 ? 1706 ARG H N    1 
ATOM   4384 C CA   . ARG H 2 8  ? 1.064   30.108 23.017  1.00 48.27 ? 1706 ARG H CA   1 
ATOM   4385 C C    . ARG H 2 8  ? -0.449  30.223 23.239  1.00 47.17 ? 1706 ARG H C    1 
ATOM   4386 O O    . ARG H 2 8  ? -1.183  29.227 23.229  1.00 49.33 ? 1706 ARG H O    1 
ATOM   4387 C CB   . ARG H 2 8  ? 1.634   31.452 22.555  1.00 49.72 ? 1706 ARG H CB   1 
ATOM   4388 H H    . ARG H 2 8  ? 1.031   29.125 21.300  1.00 44.17 ? 1706 ARG H H    1 
ATOM   4389 H HA   . ARG H 2 8  ? 1.460   29.884 23.873  1.00 58.07 ? 1706 ARG H HA   1 
HETATM 4390 C C1   . GOL I 3 .  ? -1.284  36.180 -16.504 1.00 31.95 ? 1201 GOL B C1   1 
HETATM 4391 O O1   . GOL I 3 .  ? -2.077  36.611 -15.423 1.00 38.09 ? 1201 GOL B O1   1 
HETATM 4392 C C2   . GOL I 3 .  ? 0.015   35.677 -15.829 1.00 43.41 ? 1201 GOL B C2   1 
HETATM 4393 O O2   . GOL I 3 .  ? -0.258  35.186 -14.547 1.00 38.86 ? 1201 GOL B O2   1 
HETATM 4394 C C3   . GOL I 3 .  ? 0.630   34.669 -16.790 1.00 38.15 ? 1201 GOL B C3   1 
HETATM 4395 O O3   . GOL I 3 .  ? 1.774   34.188 -16.096 1.00 35.70 ? 1201 GOL B O3   1 
HETATM 4396 H H11  . GOL I 3 .  ? -1.082  36.886 -17.138 1.00 38.48 ? 1201 GOL B H11  1 
HETATM 4397 H H12  . GOL I 3 .  ? -1.692  35.468 -17.021 1.00 38.48 ? 1201 GOL B H12  1 
HETATM 4398 H H2   . GOL I 3 .  ? 0.657   36.392 -15.701 1.00 52.24 ? 1201 GOL B H2   1 
HETATM 4399 H H31  . GOL I 3 .  ? 0.834   35.101 -17.634 1.00 45.93 ? 1201 GOL B H31  1 
HETATM 4400 H H32  . GOL I 3 .  ? -0.019  33.981 -17.005 1.00 45.93 ? 1201 GOL B H32  1 
HETATM 4401 O O    . HOH J 4 .  ? 9.400   28.541 -35.143 1.00 29.98 ? 1201 HOH A O    1 
HETATM 4402 O O    . HOH J 4 .  ? 18.577  16.240 -32.569 1.00 33.97 ? 1202 HOH A O    1 
HETATM 4403 O O    . HOH J 4 .  ? 12.224  30.762 -12.831 1.00 31.92 ? 1203 HOH A O    1 
HETATM 4404 O O    . HOH J 4 .  ? 2.438   13.180 -25.211 1.00 11.17 ? 1204 HOH A O    1 
HETATM 4405 O O    . HOH J 4 .  ? 18.693  20.690 -27.025 1.00 22.59 ? 1205 HOH A O    1 
HETATM 4406 O O    . HOH J 4 .  ? 0.794   29.097 -26.406 1.00 20.00 ? 1206 HOH A O    1 
HETATM 4407 O O    . HOH J 4 .  ? -1.935  17.763 -28.439 1.00 20.50 ? 1207 HOH A O    1 
HETATM 4408 O O    . HOH J 4 .  ? -1.413  16.134 -13.517 1.00 18.60 ? 1208 HOH A O    1 
HETATM 4409 O O    . HOH J 4 .  ? 15.636  34.539 -16.902 1.00 30.78 ? 1209 HOH A O    1 
HETATM 4410 O O    . HOH J 4 .  ? 8.347   24.465 -13.131 1.00 14.89 ? 1210 HOH A O    1 
HETATM 4411 O O    . HOH J 4 .  ? 2.499   11.809 -15.201 1.00 12.89 ? 1211 HOH A O    1 
HETATM 4412 O O    . HOH J 4 .  ? 16.945  22.391 -11.479 1.00 19.91 ? 1212 HOH A O    1 
HETATM 4413 O O    . HOH J 4 .  ? 5.461   17.106 -17.020 1.00 7.49  ? 1213 HOH A O    1 
HETATM 4414 O O    . HOH J 4 .  ? 15.635  32.048 -27.683 1.00 8.65  ? 1214 HOH A O    1 
HETATM 4415 O O    . HOH J 4 .  ? -4.369  19.440 -28.356 1.00 27.75 ? 1215 HOH A O    1 
HETATM 4416 O O    . HOH J 4 .  ? 6.792   6.975  -20.812 1.00 17.90 ? 1216 HOH A O    1 
HETATM 4417 O O    . HOH J 4 .  ? 0.283   32.331 -23.788 1.00 15.81 ? 1217 HOH A O    1 
HETATM 4418 O O    . HOH J 4 .  ? 20.882  17.094 -24.863 1.00 26.82 ? 1218 HOH A O    1 
HETATM 4419 O O    . HOH J 4 .  ? 6.937   32.173 -23.964 1.00 22.50 ? 1219 HOH A O    1 
HETATM 4420 O O    . HOH J 4 .  ? 9.112   30.626 -22.188 1.00 27.30 ? 1220 HOH A O    1 
HETATM 4421 O O    . HOH J 4 .  ? 20.482  19.728 -16.873 1.00 26.01 ? 1221 HOH A O    1 
HETATM 4422 O O    . HOH J 4 .  ? 18.508  23.028 -17.570 1.00 8.92  ? 1222 HOH A O    1 
HETATM 4423 O O    . HOH J 4 .  ? 11.600  32.431 -19.149 1.00 22.08 ? 1223 HOH A O    1 
HETATM 4424 O O    . HOH J 4 .  ? 7.955   16.212 -36.447 1.00 40.77 ? 1224 HOH A O    1 
HETATM 4425 O O    . HOH J 4 .  ? 18.442  16.325 -20.528 1.00 8.54  ? 1225 HOH A O    1 
HETATM 4426 O O    . HOH J 4 .  ? -4.309  23.924 -19.368 1.00 10.37 ? 1226 HOH A O    1 
HETATM 4427 O O    . HOH J 4 .  ? 8.284   10.781 -8.139  1.00 10.22 ? 1227 HOH A O    1 
HETATM 4428 O O    . HOH J 4 .  ? 8.095   3.970  -23.127 1.00 23.99 ? 1228 HOH A O    1 
HETATM 4429 O O    . HOH J 4 .  ? -2.422  13.572 -24.994 1.00 30.50 ? 1229 HOH A O    1 
HETATM 4430 O O    . HOH J 4 .  ? 11.830  18.082 -12.143 1.00 23.23 ? 1230 HOH A O    1 
HETATM 4431 O O    . HOH J 4 .  ? -1.350  18.461 -14.888 1.00 15.07 ? 1231 HOH A O    1 
HETATM 4432 O O    . HOH J 4 .  ? -0.776  30.905 -20.016 1.00 8.81  ? 1232 HOH A O    1 
HETATM 4433 O O    . HOH J 4 .  ? 8.371   31.073 -19.505 1.00 12.18 ? 1233 HOH A O    1 
HETATM 4434 O O    . HOH J 4 .  ? -4.980  24.370 -16.360 1.00 32.63 ? 1234 HOH A O    1 
HETATM 4435 O O    . HOH J 4 .  ? 13.393  9.624  -18.808 1.00 25.94 ? 1235 HOH A O    1 
HETATM 4436 O O    . HOH J 4 .  ? 11.204  32.040 -23.077 1.00 17.84 ? 1236 HOH A O    1 
HETATM 4437 O O    . HOH J 4 .  ? 14.699  28.937 -34.534 1.00 38.15 ? 1237 HOH A O    1 
HETATM 4438 O O    . HOH J 4 .  ? 1.122   27.437 -27.430 1.00 32.16 ? 1238 HOH A O    1 
HETATM 4439 O O    . HOH J 4 .  ? 17.108  18.131 -29.009 1.00 30.22 ? 1239 HOH A O    1 
HETATM 4440 O O    . HOH J 4 .  ? -3.950  20.621 -17.809 1.00 27.90 ? 1240 HOH A O    1 
HETATM 4441 O O    . HOH J 4 .  ? 1.989   27.152 -31.366 1.00 37.52 ? 1241 HOH A O    1 
HETATM 4442 O O    . HOH J 4 .  ? 0.795   24.660 -13.736 1.00 21.63 ? 1242 HOH A O    1 
HETATM 4443 O O    . HOH J 4 .  ? 6.242   16.434 -8.183  1.00 16.97 ? 1243 HOH A O    1 
HETATM 4444 O O    . HOH J 4 .  ? 7.246   12.144 -30.700 1.00 32.45 ? 1244 HOH A O    1 
HETATM 4445 O O    . HOH J 4 .  ? 3.308   32.837 -25.316 1.00 38.39 ? 1245 HOH A O    1 
HETATM 4446 O O    . HOH J 4 .  ? 12.734  21.636 -11.952 1.00 26.05 ? 1246 HOH A O    1 
HETATM 4447 O O    . HOH J 4 .  ? 17.164  11.484 -23.319 1.00 25.79 ? 1247 HOH A O    1 
HETATM 4448 O O    . HOH J 4 .  ? 9.983   10.857 -30.052 1.00 28.51 ? 1248 HOH A O    1 
HETATM 4449 O O    . HOH J 4 .  ? 8.859   8.884  -12.605 1.00 25.23 ? 1249 HOH A O    1 
HETATM 4450 O O    . HOH J 4 .  ? 1.842   9.335  -13.309 1.00 34.35 ? 1250 HOH A O    1 
HETATM 4451 O O    . HOH J 4 .  ? 5.614   10.386 -7.445  1.00 27.55 ? 1251 HOH A O    1 
HETATM 4452 O O    . HOH J 4 .  ? 10.230  30.089 -33.115 1.00 35.54 ? 1252 HOH A O    1 
HETATM 4453 O O    . HOH J 4 .  ? 11.047  24.590 -36.913 1.00 32.72 ? 1253 HOH A O    1 
HETATM 4454 O O    . HOH J 4 .  ? 13.288  25.194 -37.918 1.00 38.96 ? 1254 HOH A O    1 
HETATM 4455 O O    . HOH J 4 .  ? 17.702  11.889 -26.083 1.00 33.57 ? 1255 HOH A O    1 
HETATM 4456 O O    . HOH J 4 .  ? 5.123   29.284 -14.789 1.00 23.41 ? 1256 HOH A O    1 
HETATM 4457 O O    . HOH J 4 .  ? 2.578   34.355 -29.449 1.00 32.70 ? 1257 HOH A O    1 
HETATM 4458 O O    . HOH J 4 .  ? 8.551   8.636  -9.703  1.00 17.83 ? 1258 HOH A O    1 
HETATM 4459 O O    . HOH J 4 .  ? 20.385  23.921 -19.077 1.00 27.12 ? 1259 HOH A O    1 
HETATM 4460 O O    . HOH J 4 .  ? 1.529   32.990 -26.078 1.00 27.16 ? 1260 HOH A O    1 
HETATM 4461 O O    . HOH J 4 .  ? -8.835  21.424 -24.853 1.00 32.47 ? 1261 HOH A O    1 
HETATM 4462 O O    . HOH J 4 .  ? 4.307   26.747 -13.419 1.00 21.62 ? 1262 HOH A O    1 
HETATM 4463 O O    . HOH J 4 .  ? -0.445  24.503 -11.007 1.00 40.38 ? 1263 HOH A O    1 
HETATM 4464 O O    . HOH J 4 .  ? 1.772   29.631 -30.559 1.00 48.60 ? 1264 HOH A O    1 
HETATM 4465 O O    . HOH J 4 .  ? 2.367   25.479 -34.738 1.00 31.92 ? 1265 HOH A O    1 
HETATM 4466 O O    . HOH J 4 .  ? 22.420  15.957 -23.761 1.00 36.41 ? 1266 HOH A O    1 
HETATM 4467 O O    . HOH J 4 .  ? 6.148   26.215 -11.330 1.00 29.24 ? 1267 HOH A O    1 
HETATM 4468 O O    . HOH J 4 .  ? 9.490   30.824 -34.679 1.00 37.04 ? 1268 HOH A O    1 
HETATM 4469 O O    . HOH J 4 .  ? 20.115  12.612 -26.306 1.00 32.69 ? 1269 HOH A O    1 
HETATM 4470 O O    . HOH J 4 .  ? -2.118  15.373 -29.320 1.00 33.90 ? 1270 HOH A O    1 
HETATM 4471 O O    . HOH K 4 .  ? 3.386   15.855 -16.252 1.00 10.01 ? 1801 HOH E O    1 
HETATM 4472 O O    . HOH K 4 .  ? 0.615   10.471 -16.662 1.00 21.00 ? 1802 HOH E O    1 
HETATM 4473 O O    . HOH K 4 .  ? 1.655   7.467  -15.375 1.00 21.12 ? 1803 HOH E O    1 
HETATM 4474 O O    . HOH K 4 .  ? -5.135  13.290 -17.616 1.00 30.20 ? 1804 HOH E O    1 
HETATM 4475 O O    . HOH K 4 .  ? 9.450   6.233  -16.708 1.00 33.05 ? 1805 HOH E O    1 
HETATM 4476 O O    . HOH K 4 .  ? 10.675  7.198  -14.361 1.00 35.78 ? 1806 HOH E O    1 
HETATM 4477 O O    . HOH K 4 .  ? -4.661  15.502 -17.289 1.00 35.97 ? 1807 HOH E O    1 
HETATM 4478 O O    . HOH K 4 .  ? -1.864  10.883 -16.155 1.00 33.86 ? 1808 HOH E O    1 
HETATM 4479 O O    . HOH L 4 .  ? -1.891  35.253 -13.114 1.00 39.75 ? 1301 HOH B O    1 
HETATM 4480 O O    . HOH L 4 .  ? -17.573 42.953 -22.017 1.00 10.12 ? 1302 HOH B O    1 
HETATM 4481 O O    . HOH L 4 .  ? -17.403 44.146 -32.049 1.00 10.21 ? 1303 HOH B O    1 
HETATM 4482 O O    . HOH L 4 .  ? -8.823  23.964 -23.929 1.00 19.82 ? 1304 HOH B O    1 
HETATM 4483 O O    . HOH L 4 .  ? -3.140  33.829 -35.441 1.00 22.36 ? 1305 HOH B O    1 
HETATM 4484 O O    . HOH L 4 .  ? -2.257  25.931 -9.886  1.00 47.85 ? 1306 HOH B O    1 
HETATM 4485 O O    . HOH L 4 .  ? -7.702  25.308 -34.215 1.00 32.67 ? 1307 HOH B O    1 
HETATM 4486 O O    . HOH L 4 .  ? -21.404 39.986 -33.806 1.00 24.86 ? 1308 HOH B O    1 
HETATM 4487 O O    . HOH L 4 .  ? -1.549  33.064 -29.611 1.00 8.44  ? 1309 HOH B O    1 
HETATM 4488 O O    . HOH L 4 .  ? -10.877 25.559 -24.999 1.00 23.01 ? 1310 HOH B O    1 
HETATM 4489 O O    . HOH L 4 .  ? -22.008 38.256 -18.831 1.00 24.29 ? 1311 HOH B O    1 
HETATM 4490 O O    . HOH L 4 .  ? -11.652 25.193 -27.550 1.00 9.35  ? 1312 HOH B O    1 
HETATM 4491 O O    . HOH L 4 .  ? -1.090  35.427 -20.150 1.00 24.10 ? 1313 HOH B O    1 
HETATM 4492 O O    . HOH L 4 .  ? -22.500 29.324 -21.055 1.00 9.54  ? 1314 HOH B O    1 
HETATM 4493 O O    . HOH L 4 .  ? -1.605  25.691 -13.123 1.00 32.61 ? 1315 HOH B O    1 
HETATM 4494 O O    . HOH L 4 .  ? -4.572  21.460 -30.221 1.00 20.87 ? 1316 HOH B O    1 
HETATM 4495 O O    . HOH L 4 .  ? -14.517 38.883 -29.986 1.00 6.63  ? 1317 HOH B O    1 
HETATM 4496 O O    . HOH L 4 .  ? -11.438 31.755 -34.133 1.00 13.73 ? 1318 HOH B O    1 
HETATM 4497 O O    . HOH L 4 .  ? -1.397  32.102 -13.609 1.00 34.02 ? 1319 HOH B O    1 
HETATM 4498 O O    . HOH L 4 .  ? -11.663 45.159 -39.048 1.00 13.65 ? 1320 HOH B O    1 
HETATM 4499 O O    . HOH L 4 .  ? -15.343 48.941 -37.294 1.00 40.07 ? 1321 HOH B O    1 
HETATM 4500 O O    . HOH L 4 .  ? -8.254  23.581 -27.944 1.00 22.90 ? 1322 HOH B O    1 
HETATM 4501 O O    . HOH L 4 .  ? -19.795 23.659 -23.513 1.00 10.46 ? 1323 HOH B O    1 
HETATM 4502 O O    . HOH L 4 .  ? -2.491  26.882 -26.158 1.00 8.66  ? 1324 HOH B O    1 
HETATM 4503 O O    . HOH L 4 .  ? -6.927  41.003 -15.639 1.00 29.88 ? 1325 HOH B O    1 
HETATM 4504 O O    . HOH L 4 .  ? -12.839 24.025 -23.100 1.00 23.90 ? 1326 HOH B O    1 
HETATM 4505 O O    . HOH L 4 .  ? -24.202 36.623 -18.712 1.00 25.78 ? 1327 HOH B O    1 
HETATM 4506 O O    . HOH L 4 .  ? -22.160 42.775 -22.298 1.00 35.45 ? 1328 HOH B O    1 
HETATM 4507 O O    . HOH L 4 .  ? -6.435  46.549 -28.593 1.00 24.65 ? 1329 HOH B O    1 
HETATM 4508 O O    . HOH L 4 .  ? -7.644  37.800 -35.107 1.00 23.25 ? 1330 HOH B O    1 
HETATM 4509 O O    . HOH L 4 .  ? -24.743 31.674 -31.193 1.00 24.49 ? 1331 HOH B O    1 
HETATM 4510 O O    . HOH L 4 .  ? -23.899 34.855 -29.362 1.00 29.47 ? 1332 HOH B O    1 
HETATM 4511 O O    . HOH L 4 .  ? -21.298 37.654 -32.200 1.00 12.83 ? 1333 HOH B O    1 
HETATM 4512 O O    . HOH L 4 .  ? -18.429 49.360 -19.211 1.00 34.84 ? 1334 HOH B O    1 
HETATM 4513 O O    . HOH L 4 .  ? -12.940 43.917 -16.517 1.00 35.87 ? 1335 HOH B O    1 
HETATM 4514 O O    . HOH L 4 .  ? -1.568  39.656 -14.556 1.00 35.75 ? 1336 HOH B O    1 
HETATM 4515 O O    . HOH L 4 .  ? -10.191 27.143 -11.574 1.00 42.08 ? 1337 HOH B O    1 
HETATM 4516 O O    . HOH L 4 .  ? -3.756  27.141 -33.375 1.00 19.52 ? 1338 HOH B O    1 
HETATM 4517 O O    . HOH L 4 .  ? -20.797 25.137 -27.154 1.00 13.37 ? 1339 HOH B O    1 
HETATM 4518 O O    . HOH L 4 .  ? -15.311 49.297 -16.293 1.00 40.42 ? 1340 HOH B O    1 
HETATM 4519 O O    . HOH L 4 .  ? -7.842  34.527 -34.875 1.00 33.98 ? 1341 HOH B O    1 
HETATM 4520 O O    . HOH L 4 .  ? -17.385 38.690 -16.981 1.00 29.94 ? 1342 HOH B O    1 
HETATM 4521 O O    . HOH L 4 .  ? -10.089 45.164 -17.245 1.00 29.08 ? 1343 HOH B O    1 
HETATM 4522 O O    . HOH L 4 .  ? -0.506  42.764 -23.450 1.00 33.48 ? 1344 HOH B O    1 
HETATM 4523 O O    . HOH L 4 .  ? -19.122 31.560 -33.338 1.00 18.29 ? 1345 HOH B O    1 
HETATM 4524 O O    . HOH L 4 .  ? -10.792 47.126 -34.577 1.00 20.70 ? 1346 HOH B O    1 
HETATM 4525 O O    . HOH L 4 .  ? -2.577  44.706 -23.186 1.00 32.62 ? 1347 HOH B O    1 
HETATM 4526 O O    . HOH L 4 .  ? -3.243  41.581 -15.728 1.00 46.09 ? 1348 HOH B O    1 
HETATM 4527 O O    . HOH L 4 .  ? -10.643 34.358 -34.278 1.00 20.19 ? 1349 HOH B O    1 
HETATM 4528 O O    . HOH L 4 .  ? -16.992 49.036 -17.912 1.00 33.65 ? 1350 HOH B O    1 
HETATM 4529 O O    . HOH L 4 .  ? -3.172  30.860 -12.995 1.00 35.17 ? 1351 HOH B O    1 
HETATM 4530 O O    . HOH L 4 .  ? -12.419 23.598 -19.949 1.00 33.11 ? 1352 HOH B O    1 
HETATM 4531 O O    . HOH L 4 .  ? -17.990 46.703 -33.638 1.00 34.40 ? 1353 HOH B O    1 
HETATM 4532 O O    . HOH L 4 .  ? -16.894 23.691 -26.274 1.00 22.62 ? 1354 HOH B O    1 
HETATM 4533 O O    . HOH L 4 .  ? 0.232   31.316 -13.724 1.00 35.85 ? 1355 HOH B O    1 
HETATM 4534 O O    . HOH L 4 .  ? -9.852  24.773 -16.123 1.00 28.40 ? 1356 HOH B O    1 
HETATM 4535 O O    . HOH L 4 .  ? -14.732 26.789 -32.357 1.00 24.66 ? 1357 HOH B O    1 
HETATM 4536 O O    . HOH L 4 .  ? -26.526 34.593 -17.720 1.00 35.50 ? 1358 HOH B O    1 
HETATM 4537 O O    . HOH L 4 .  ? -11.226 47.439 -37.420 1.00 16.42 ? 1359 HOH B O    1 
HETATM 4538 O O    . HOH L 4 .  ? -3.598  33.361 -12.137 1.00 32.75 ? 1360 HOH B O    1 
HETATM 4539 O O    . HOH L 4 .  ? -14.300 40.934 -39.527 1.00 31.53 ? 1361 HOH B O    1 
HETATM 4540 O O    . HOH L 4 .  ? -9.299  25.921 -14.086 1.00 39.14 ? 1362 HOH B O    1 
HETATM 4541 O O    . HOH L 4 .  ? -5.747  22.829 -18.093 1.00 28.20 ? 1363 HOH B O    1 
HETATM 4542 O O    . HOH L 4 .  ? -2.093  41.647 -18.871 1.00 37.82 ? 1364 HOH B O    1 
HETATM 4543 O O    . HOH L 4 .  ? -7.479  23.245 -15.416 1.00 32.33 ? 1365 HOH B O    1 
HETATM 4544 O O    . HOH L 4 .  ? -15.642 28.704 -34.097 1.00 23.74 ? 1366 HOH B O    1 
HETATM 4545 O O    . HOH L 4 .  ? -13.687 29.570 -35.637 1.00 28.69 ? 1367 HOH B O    1 
HETATM 4546 O O    . HOH L 4 .  ? -17.538 22.272 -24.960 1.00 39.75 ? 1368 HOH B O    1 
HETATM 4547 O O    . HOH L 4 .  ? -19.642 22.645 -26.584 1.00 35.50 ? 1369 HOH B O    1 
HETATM 4548 O O    . HOH L 4 .  ? -15.888 39.502 -40.928 1.00 39.46 ? 1370 HOH B O    1 
HETATM 4549 O O    . HOH L 4 .  ? -5.414  21.824 -10.306 1.00 32.39 ? 1371 HOH B O    1 
HETATM 4550 O O    . HOH L 4 .  ? -7.798  22.014 -11.774 1.00 47.45 ? 1372 HOH B O    1 
HETATM 4551 O O    . HOH L 4 .  ? 1.902   43.274 -21.564 1.00 40.98 ? 1373 HOH B O    1 
HETATM 4552 O O    . HOH L 4 .  ? 3.776   39.286 -21.765 1.00 35.88 ? 1374 HOH B O    1 
HETATM 4553 O O    . HOH L 4 .  ? 5.559   37.943 -19.946 1.00 39.53 ? 1375 HOH B O    1 
HETATM 4554 O O    . HOH M 4 .  ? -12.730 51.897 -31.008 1.00 40.02 ? 1801 HOH C O    1 
HETATM 4555 O O    . HOH M 4 .  ? -10.801 52.949 -30.917 1.00 38.21 ? 1802 HOH C O    1 
HETATM 4556 O O    . HOH M 4 .  ? -13.137 49.106 -26.400 1.00 17.75 ? 1803 HOH C O    1 
HETATM 4557 O O    . HOH M 4 .  ? -16.596 40.199 -30.977 1.00 10.51 ? 1804 HOH C O    1 
HETATM 4558 O O    . HOH M 4 .  ? -19.290 45.534 -30.407 1.00 19.11 ? 1805 HOH C O    1 
HETATM 4559 O O    . HOH M 4 .  ? -18.188 48.694 -31.657 1.00 19.88 ? 1806 HOH C O    1 
HETATM 4560 O O    . HOH M 4 .  ? -9.149  48.766 -32.841 1.00 37.06 ? 1807 HOH C O    1 
HETATM 4561 O O    . HOH N 4 .  ? -31.915 8.871  -0.565  1.00 23.32 ? 1201 HOH D O    1 
HETATM 4562 O O    . HOH N 4 .  ? -13.292 3.499  -7.958  1.00 30.85 ? 1202 HOH D O    1 
HETATM 4563 O O    . HOH N 4 .  ? -14.069 15.667 5.413   1.00 14.78 ? 1203 HOH D O    1 
HETATM 4564 O O    . HOH N 4 .  ? -17.855 12.095 -21.600 1.00 37.94 ? 1204 HOH D O    1 
HETATM 4565 O O    . HOH N 4 .  ? -26.572 10.339 -15.782 1.00 8.10  ? 1205 HOH D O    1 
HETATM 4566 O O    . HOH N 4 .  ? -13.592 19.569 5.697   1.00 15.11 ? 1206 HOH D O    1 
HETATM 4567 O O    . HOH N 4 .  ? -31.783 17.678 -5.464  1.00 12.74 ? 1207 HOH D O    1 
HETATM 4568 O O    . HOH N 4 .  ? -15.580 11.924 -14.975 1.00 17.11 ? 1208 HOH D O    1 
HETATM 4569 O O    . HOH N 4 .  ? -18.732 14.043 -9.785  1.00 3.97  ? 1209 HOH D O    1 
HETATM 4570 O O    . HOH N 4 .  ? -11.134 6.438  -1.482  1.00 26.07 ? 1210 HOH D O    1 
HETATM 4571 O O    . HOH N 4 .  ? -24.909 22.862 2.587   1.00 23.83 ? 1211 HOH D O    1 
HETATM 4572 O O    . HOH N 4 .  ? -32.920 21.026 -9.770  1.00 32.82 ? 1212 HOH D O    1 
HETATM 4573 O O    . HOH N 4 .  ? -17.437 5.244  0.014   1.00 31.96 ? 1213 HOH D O    1 
HETATM 4574 O O    . HOH N 4 .  ? -17.490 2.141  -13.337 1.00 35.05 ? 1214 HOH D O    1 
HETATM 4575 O O    . HOH N 4 .  ? -12.587 21.346 2.186   1.00 13.04 ? 1215 HOH D O    1 
HETATM 4576 O O    . HOH N 4 .  ? -29.397 24.327 -3.747  1.00 17.14 ? 1216 HOH D O    1 
HETATM 4577 O O    . HOH N 4 .  ? -22.869 19.501 3.149   1.00 35.73 ? 1217 HOH D O    1 
HETATM 4578 O O    . HOH N 4 .  ? -24.374 19.656 5.220   1.00 24.86 ? 1218 HOH D O    1 
HETATM 4579 O O    . HOH N 4 .  ? -21.713 21.652 1.921   1.00 12.14 ? 1219 HOH D O    1 
HETATM 4580 O O    . HOH N 4 .  ? -23.247 0.397  -5.315  1.00 37.83 ? 1220 HOH D O    1 
HETATM 4581 O O    . HOH N 4 .  ? -26.667 7.447  -14.349 1.00 30.06 ? 1221 HOH D O    1 
HETATM 4582 O O    . HOH N 4 .  ? -22.389 11.748 -18.873 1.00 21.73 ? 1222 HOH D O    1 
HETATM 4583 O O    . HOH N 4 .  ? -28.661 9.567  10.020  1.00 35.87 ? 1223 HOH D O    1 
HETATM 4584 O O    . HOH N 4 .  ? -15.689 5.141  -7.030  1.00 18.16 ? 1224 HOH D O    1 
HETATM 4585 O O    . HOH N 4 .  ? -14.614 18.224 -18.935 1.00 30.33 ? 1225 HOH D O    1 
HETATM 4586 O O    . HOH N 4 .  ? -25.224 18.340 -12.599 1.00 23.21 ? 1226 HOH D O    1 
HETATM 4587 O O    . HOH N 4 .  ? -30.569 21.339 -9.603  1.00 27.95 ? 1227 HOH D O    1 
HETATM 4588 O O    . HOH N 4 .  ? -34.447 8.138  -4.762  1.00 31.59 ? 1228 HOH D O    1 
HETATM 4589 O O    . HOH N 4 .  ? -21.788 21.979 -7.343  1.00 14.61 ? 1229 HOH D O    1 
HETATM 4590 O O    . HOH N 4 .  ? -8.333  19.659 -4.788  1.00 32.00 ? 1230 HOH D O    1 
HETATM 4591 O O    . HOH N 4 .  ? -33.112 20.385 -6.966  1.00 27.15 ? 1231 HOH D O    1 
HETATM 4592 O O    . HOH N 4 .  ? -11.871 16.415 -10.206 1.00 19.07 ? 1232 HOH D O    1 
HETATM 4593 O O    . HOH N 4 .  ? -8.918  7.273  -0.221  1.00 32.99 ? 1233 HOH D O    1 
HETATM 4594 O O    . HOH N 4 .  ? -18.677 12.049 11.069  1.00 35.28 ? 1234 HOH D O    1 
HETATM 4595 O O    . HOH N 4 .  ? -25.969 20.619 -9.962  1.00 30.82 ? 1235 HOH D O    1 
HETATM 4596 O O    . HOH N 4 .  ? -18.850 16.244 -21.309 1.00 29.55 ? 1236 HOH D O    1 
HETATM 4597 O O    . HOH N 4 .  ? -20.475 0.314  -4.209  1.00 36.59 ? 1237 HOH D O    1 
HETATM 4598 O O    . HOH N 4 .  ? -15.195 11.616 -17.884 1.00 27.63 ? 1238 HOH D O    1 
HETATM 4599 O O    . HOH N 4 .  ? -20.581 19.535 5.914   1.00 32.40 ? 1239 HOH D O    1 
HETATM 4600 O O    . HOH N 4 .  ? -30.534 5.335  -9.476  1.00 29.16 ? 1240 HOH D O    1 
HETATM 4601 O O    . HOH N 4 .  ? -25.090 6.439  10.839  1.00 33.21 ? 1241 HOH D O    1 
HETATM 4602 O O    . HOH N 4 .  ? -16.463 25.089 -10.413 1.00 34.09 ? 1242 HOH D O    1 
HETATM 4603 O O    . HOH N 4 .  ? -19.895 22.311 -12.271 1.00 32.96 ? 1243 HOH D O    1 
HETATM 4604 O O    . HOH N 4 .  ? -9.099  16.125 -6.492  1.00 41.11 ? 1244 HOH D O    1 
HETATM 4605 O O    . HOH N 4 .  ? -14.234 21.718 -6.564  1.00 20.92 ? 1245 HOH D O    1 
HETATM 4606 O O    . HOH N 4 .  ? -16.889 4.521  3.941   1.00 28.05 ? 1246 HOH D O    1 
HETATM 4607 O O    . HOH N 4 .  ? -32.737 6.409  -8.231  1.00 34.61 ? 1247 HOH D O    1 
HETATM 4608 O O    . HOH N 4 .  ? -22.338 20.492 -9.557  1.00 17.50 ? 1248 HOH D O    1 
HETATM 4609 O O    . HOH N 4 .  ? -33.978 18.484 -7.869  1.00 18.15 ? 1249 HOH D O    1 
HETATM 4610 O O    . HOH N 4 .  ? -15.511 10.945 6.962   1.00 34.82 ? 1250 HOH D O    1 
HETATM 4611 O O    . HOH N 4 .  ? -11.718 19.669 -7.737  1.00 33.89 ? 1251 HOH D O    1 
HETATM 4612 O O    . HOH N 4 .  ? -12.130 7.995  8.252   1.00 33.83 ? 1252 HOH D O    1 
HETATM 4613 O O    . HOH N 4 .  ? -31.045 3.781  -7.305  1.00 42.24 ? 1253 HOH D O    1 
HETATM 4614 O O    . HOH N 4 .  ? -23.908 9.826  -19.223 1.00 24.86 ? 1254 HOH D O    1 
HETATM 4615 O O    . HOH N 4 .  ? -18.453 24.054 -2.737  1.00 23.75 ? 1255 HOH D O    1 
HETATM 4616 O O    . HOH N 4 .  ? -14.897 13.177 5.297   1.00 28.42 ? 1256 HOH D O    1 
HETATM 4617 O O    . HOH N 4 .  ? -11.513 21.970 -6.722  1.00 42.43 ? 1257 HOH D O    1 
HETATM 4618 O O    . HOH N 4 .  ? -17.722 23.485 -5.181  1.00 19.38 ? 1258 HOH D O    1 
HETATM 4619 O O    . HOH N 4 .  ? -33.778 17.356 -3.667  1.00 25.79 ? 1259 HOH D O    1 
HETATM 4620 O O    . HOH N 4 .  ? -22.022 13.644 -21.134 1.00 19.93 ? 1260 HOH D O    1 
HETATM 4621 O O    . HOH N 4 .  ? -24.452 4.210  9.693   1.00 35.80 ? 1261 HOH D O    1 
HETATM 4622 O O    . HOH N 4 .  ? -28.028 25.238 -4.789  1.00 30.22 ? 1262 HOH D O    1 
HETATM 4623 O O    . HOH N 4 .  ? -32.037 7.916  10.661  1.00 35.44 ? 1263 HOH D O    1 
HETATM 4624 O O    . HOH N 4 .  ? -10.116 19.483 -10.025 1.00 41.79 ? 1264 HOH D O    1 
HETATM 4625 O O    . HOH N 4 .  ? -9.934  21.348 -7.701  1.00 34.82 ? 1265 HOH D O    1 
HETATM 4626 O O    . HOH N 4 .  ? -9.298  18.700 -8.134  1.00 51.84 ? 1266 HOH D O    1 
HETATM 4627 O O    . HOH N 4 .  ? -15.436 23.804 -6.100  1.00 29.86 ? 1267 HOH D O    1 
HETATM 4628 O O    . HOH N 4 .  ? -29.514 6.915  11.786  1.00 42.52 ? 1268 HOH D O    1 
HETATM 4629 O O    . HOH O 4 .  ? -11.973 15.909 -12.819 1.00 23.37 ? 1801 HOH F O    1 
HETATM 4630 O O    . HOH O 4 .  ? -13.868 9.860  -14.724 1.00 28.79 ? 1802 HOH F O    1 
HETATM 4631 O O    . HOH O 4 .  ? -14.780 8.636  -17.678 1.00 39.91 ? 1803 HOH F O    1 
HETATM 4632 O O    . HOH O 4 .  ? -16.637 13.744 -11.268 1.00 11.78 ? 1804 HOH F O    1 
HETATM 4633 O O    . HOH O 4 .  ? -8.186  10.876 -12.227 1.00 33.65 ? 1805 HOH F O    1 
HETATM 4634 O O    . HOH O 4 .  ? -12.143 3.048  -12.998 1.00 43.50 ? 1806 HOH F O    1 
HETATM 4635 O O    . HOH O 4 .  ? -20.416 -5.492 -20.029 1.00 39.21 ? 1807 HOH F O    1 
HETATM 4636 O O    . HOH O 4 .  ? -17.763 -2.410 -20.623 1.00 43.42 ? 1808 HOH F O    1 
HETATM 4637 O O    . HOH P 4 .  ? -11.857 24.773 5.434   1.00 23.02 ? 1201 HOH G O    1 
HETATM 4638 O O    . HOH P 4 .  ? -13.458 12.183 14.683  1.00 41.24 ? 1202 HOH G O    1 
HETATM 4639 O O    . HOH P 4 .  ? -7.659  24.205 -5.325  1.00 31.13 ? 1203 HOH G O    1 
HETATM 4640 O O    . HOH P 4 .  ? 1.717   21.431 -5.506  1.00 30.35 ? 1204 HOH G O    1 
HETATM 4641 O O    . HOH P 4 .  ? -3.619  14.312 2.706   1.00 28.83 ? 1205 HOH G O    1 
HETATM 4642 O O    . HOH P 4 .  ? -10.152 12.007 14.980  1.00 22.85 ? 1206 HOH G O    1 
HETATM 4643 O O    . HOH P 4 .  ? -6.648  23.170 20.953  1.00 14.53 ? 1207 HOH G O    1 
HETATM 4644 O O    . HOH P 4 .  ? 9.220   19.456 1.696   1.00 13.61 ? 1208 HOH G O    1 
HETATM 4645 O O    . HOH P 4 .  ? 1.233   19.481 14.921  1.00 5.61  ? 1209 HOH G O    1 
HETATM 4646 O O    . HOH P 4 .  ? -11.914 15.794 10.714  1.00 10.52 ? 1210 HOH G O    1 
HETATM 4647 O O    . HOH P 4 .  ? 8.096   17.250 18.185  1.00 25.22 ? 1211 HOH G O    1 
HETATM 4648 O O    . HOH P 4 .  ? -10.718 14.110 3.441   1.00 11.32 ? 1212 HOH G O    1 
HETATM 4649 O O    . HOH P 4 .  ? -1.519  17.101 25.581  1.00 14.08 ? 1213 HOH G O    1 
HETATM 4650 O O    . HOH P 4 .  ? 8.859   27.135 6.659   1.00 31.51 ? 1214 HOH G O    1 
HETATM 4651 O O    . HOH P 4 .  ? -1.718  11.889 3.108   1.00 12.19 ? 1215 HOH G O    1 
HETATM 4652 O O    . HOH P 4 .  ? 4.351   21.609 19.964  1.00 13.70 ? 1216 HOH G O    1 
HETATM 4653 O O    . HOH P 4 .  ? 2.310   31.049 18.558  1.00 29.41 ? 1217 HOH G O    1 
HETATM 4654 O O    . HOH P 4 .  ? 4.383   28.119 12.373  1.00 16.03 ? 1218 HOH G O    1 
HETATM 4655 O O    . HOH P 4 .  ? -2.153  13.852 1.466   1.00 24.59 ? 1219 HOH G O    1 
HETATM 4656 O O    . HOH P 4 .  ? 5.872   18.292 -0.194  1.00 15.38 ? 1220 HOH G O    1 
HETATM 4657 O O    . HOH P 4 .  ? 3.265   19.691 16.496  1.00 12.71 ? 1221 HOH G O    1 
HETATM 4658 O O    . HOH P 4 .  ? 7.367   12.182 2.856   1.00 13.36 ? 1222 HOH G O    1 
HETATM 4659 O O    . HOH P 4 .  ? -5.091  10.544 2.458   1.00 26.24 ? 1223 HOH G O    1 
HETATM 4660 O O    . HOH P 4 .  ? 6.329   13.780 -0.754  1.00 15.73 ? 1224 HOH G O    1 
HETATM 4661 O O    . HOH P 4 .  ? 10.953  16.626 8.388   1.00 14.67 ? 1225 HOH G O    1 
HETATM 4662 O O    . HOH P 4 .  ? -6.706  25.862 19.730  1.00 28.70 ? 1226 HOH G O    1 
HETATM 4663 O O    . HOH P 4 .  ? -14.224 14.977 13.274  1.00 32.58 ? 1227 HOH G O    1 
HETATM 4664 O O    . HOH P 4 .  ? -8.988  17.011 -3.265  1.00 12.92 ? 1228 HOH G O    1 
HETATM 4665 O O    . HOH P 4 .  ? -1.851  11.495 12.437  1.00 16.17 ? 1229 HOH G O    1 
HETATM 4666 O O    . HOH P 4 .  ? 7.463   15.751 22.364  1.00 24.39 ? 1230 HOH G O    1 
HETATM 4667 O O    . HOH P 4 .  ? 1.056   17.161 26.122  1.00 31.35 ? 1231 HOH G O    1 
HETATM 4668 O O    . HOH P 4 .  ? -9.531  9.156  8.693   1.00 23.12 ? 1232 HOH G O    1 
HETATM 4669 O O    . HOH P 4 .  ? 10.624  17.389 11.601  1.00 31.56 ? 1233 HOH G O    1 
HETATM 4670 O O    . HOH P 4 .  ? 8.137   16.903 15.269  1.00 17.08 ? 1234 HOH G O    1 
HETATM 4671 O O    . HOH P 4 .  ? -0.554  33.244 9.372   1.00 36.13 ? 1235 HOH G O    1 
HETATM 4672 O O    . HOH P 4 .  ? -0.657  13.995 -0.600  1.00 23.78 ? 1236 HOH G O    1 
HETATM 4673 O O    . HOH P 4 .  ? -2.425  21.746 23.986  1.00 21.53 ? 1237 HOH G O    1 
HETATM 4674 O O    . HOH P 4 .  ? -12.895 26.871 13.221  1.00 34.87 ? 1238 HOH G O    1 
HETATM 4675 O O    . HOH P 4 .  ? 2.848   28.939 1.452   1.00 32.84 ? 1239 HOH G O    1 
HETATM 4676 O O    . HOH P 4 .  ? -5.316  15.554 17.857  1.00 22.87 ? 1240 HOH G O    1 
HETATM 4677 O O    . HOH P 4 .  ? 11.263  13.050 10.728  1.00 28.84 ? 1241 HOH G O    1 
HETATM 4678 O O    . HOH P 4 .  ? -0.368  11.586 17.155  1.00 34.81 ? 1242 HOH G O    1 
HETATM 4679 O O    . HOH P 4 .  ? 11.000  26.229 5.347   1.00 26.38 ? 1243 HOH G O    1 
HETATM 4680 O O    . HOH P 4 .  ? 0.357   13.659 22.017  1.00 30.20 ? 1244 HOH G O    1 
HETATM 4681 O O    . HOH P 4 .  ? -4.434  13.734 -0.079  1.00 22.12 ? 1245 HOH G O    1 
HETATM 4682 O O    . HOH P 4 .  ? -14.668 25.131 10.030  1.00 25.45 ? 1246 HOH G O    1 
HETATM 4683 O O    . HOH P 4 .  ? -3.190  19.961 -5.006  1.00 32.55 ? 1247 HOH G O    1 
HETATM 4684 O O    . HOH P 4 .  ? -3.413  17.900 -4.521  1.00 41.28 ? 1248 HOH G O    1 
HETATM 4685 O O    . HOH P 4 .  ? 5.899   12.022 11.762  1.00 21.98 ? 1249 HOH G O    1 
HETATM 4686 O O    . HOH P 4 .  ? -11.738 26.976 -1.781  1.00 33.17 ? 1250 HOH G O    1 
HETATM 4687 O O    . HOH P 4 .  ? -5.848  12.651 15.167  1.00 31.66 ? 1251 HOH G O    1 
HETATM 4688 O O    . HOH P 4 .  ? -6.658  7.456  8.348   1.00 43.22 ? 1252 HOH G O    1 
HETATM 4689 O O    . HOH P 4 .  ? -2.786  13.356 14.603  1.00 20.79 ? 1253 HOH G O    1 
HETATM 4690 O O    . HOH P 4 .  ? 7.514   29.584 12.510  1.00 33.14 ? 1254 HOH G O    1 
HETATM 4691 O O    . HOH P 4 .  ? 1.321   9.391  7.593   1.00 25.82 ? 1255 HOH G O    1 
HETATM 4692 O O    . HOH P 4 .  ? 8.458   21.658 20.544  1.00 34.02 ? 1256 HOH G O    1 
HETATM 4693 O O    . HOH P 4 .  ? 6.708   14.021 21.371  1.00 33.50 ? 1257 HOH G O    1 
HETATM 4694 O O    . HOH P 4 .  ? -4.212  23.765 24.393  1.00 33.86 ? 1258 HOH G O    1 
HETATM 4695 O O    . HOH P 4 .  ? -2.030  19.911 26.066  1.00 18.30 ? 1259 HOH G O    1 
HETATM 4696 O O    . HOH P 4 .  ? 2.079   9.657  10.274  1.00 23.48 ? 1260 HOH G O    1 
HETATM 4697 O O    . HOH P 4 .  ? -7.991  7.958  10.567  1.00 31.19 ? 1261 HOH G O    1 
HETATM 4698 O O    . HOH P 4 .  ? -4.993  18.122 -6.770  1.00 34.71 ? 1262 HOH G O    1 
HETATM 4699 O O    . HOH P 4 .  ? -16.204 25.119 11.173  1.00 34.47 ? 1263 HOH G O    1 
HETATM 4700 O O    . HOH P 4 .  ? -0.921  16.558 -3.361  1.00 33.23 ? 1264 HOH G O    1 
HETATM 4701 O O    . HOH P 4 .  ? -12.491 27.451 2.964   1.00 32.06 ? 1265 HOH G O    1 
HETATM 4702 O O    . HOH P 4 .  ? -14.972 26.681 1.465   1.00 28.91 ? 1266 HOH G O    1 
HETATM 4703 O O    . HOH P 4 .  ? -13.910 26.250 3.312   1.00 31.72 ? 1267 HOH G O    1 
HETATM 4704 O O    . HOH P 4 .  ? 4.089   20.472 29.658  1.00 42.75 ? 1268 HOH G O    1 
HETATM 4705 O O    . HOH Q 4 .  ? -2.187  27.115 22.479  1.00 36.08 ? 1801 HOH H O    1 
HETATM 4706 O O    . HOH Q 4 .  ? 9.112   27.417 12.372  1.00 35.51 ? 1802 HOH H O    1 
HETATM 4707 O O    . HOH Q 4 .  ? 5.984   23.499 19.812  1.00 33.74 ? 1803 HOH H O    1 
HETATM 4708 O O    . HOH Q 4 .  ? 11.597  22.689 17.524  1.00 32.08 ? 1804 HOH H O    1 
HETATM 4709 O O    . HOH Q 4 .  ? 19.459  27.514 19.338  1.00 33.32 ? 1805 HOH H O    1 
HETATM 4710 O O    . HOH Q 4 .  ? 11.184  20.236 16.109  1.00 36.65 ? 1806 HOH H O    1 
# 
