data_8Z95
# 
_entry.id   8Z95 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Z95         pdb_00008z95 10.2210/pdb8z95/pdb 
WWPDB D_1300047055 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Z95 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 cycytl@nycu.edu.tw      Chin-Yuan Chang ? 'principal investigator/group leader' 0000-0001-7314-3967 
4 ycsu-johnny@nycu.edu.tw Yu-Cheng  Su    ? 'principal investigator/group leader' 0000-0001-7056-6315 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lin, Y.C.'   1 ? 
'Chang, C.Y.' 2 ? 
'Su, Y.C.'    3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Nano' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1936-086X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            19 
_citation.language                  ? 
_citation.page_first                307 
_citation.page_last                 321 
_citation.title                     
'pH-Responsive Polyethylene Glycol Engagers for Enhanced Brain Delivery of PEGylated Nanomedicine to Treat Glioblastoma.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsnano.4c05906 
_citation.pdbx_database_id_PubMed   39749925 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Meng, J.L.'    1  ?                   
primary 'Dong, Z.X.'    2  ?                   
primary 'Chen, Y.R.'    3  ?                   
primary 'Lin, M.H.'     4  ?                   
primary 'Liu, Y.C.'     5  ?                   
primary 'Roffler, S.R.' 6  0000-0003-2543-7295 
primary 'Lin, W.W.'     7  0000-0002-5144-6868 
primary 'Chang, C.Y.'   8  ?                   
primary 'Tzou, S.C.'    9  0000-0002-6620-8571 
primary 'Cheng, T.L.'   10 0000-0001-6424-4731 
primary 'Huang, H.C.'   11 ?                   
primary 'Li, Z.Q.'      12 ?                   
primary 'Lin, Y.C.'     13 ?                   
primary 'Su, Y.C.'      14 0000-0001-7056-6315 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Heavy chain of Anti-PEG antibody h6-3 Fab fragment'                                                         
23447.297 2   ? ? ? 'Heavy chain' 
2 polymer     man 'Light chain of Anti-PEG antibody h6-3 Fab fragment'                                                         
24099.793 2   ? ? ? 'light chain' 
3 non-polymer nat 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL 
1221.461  1   ? ? ? ?             
4 non-polymer syn 'ISOPROPYL ALCOHOL'                                                                                          
60.095    1   ? ? ? ?             
5 water       nat water                                                                                                        
18.015    180 ? ? ? ?             
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;QVQLVQSGSELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGQPIYANDFKGRFVFSLDTSVSTAY
LQISSLKAEDTAVYYCARDWGPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGAL
TSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK
;
;QVQLVQSGSELKKPGASVKVSCKASGYTFTNYGMNWVRQAPGQGLEWMGWINTYTGQPIYANDFKGRFVFSLDTSVSTAY
LQISSLKAEDTAVYYCARDWGPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGAL
TSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK
;
A,H ? 
2 'polypeptide(L)' no no 
;DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNQMNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLT
ISSLQAEDVAVYYCLQYLSSWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKLYACEVTHQGLSSPVTKSFNRGEC
;
;DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNQMNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLT
ISSLQAEDVAVYYCLQYLSSWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKLYACEVTHQGLSSPVTKSFNRGEC
;
B,L ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL PEU 
4 'ISOPROPYL ALCOHOL'                                                                                          IPA 
5 water                                                                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLN n 
1 2   VAL n 
1 3   GLN n 
1 4   LEU n 
1 5   VAL n 
1 6   GLN n 
1 7   SER n 
1 8   GLY n 
1 9   SER n 
1 10  GLU n 
1 11  LEU n 
1 12  LYS n 
1 13  LYS n 
1 14  PRO n 
1 15  GLY n 
1 16  ALA n 
1 17  SER n 
1 18  VAL n 
1 19  LYS n 
1 20  VAL n 
1 21  SER n 
1 22  CYS n 
1 23  LYS n 
1 24  ALA n 
1 25  SER n 
1 26  GLY n 
1 27  TYR n 
1 28  THR n 
1 29  PHE n 
1 30  THR n 
1 31  ASN n 
1 32  TYR n 
1 33  GLY n 
1 34  MET n 
1 35  ASN n 
1 36  TRP n 
1 37  VAL n 
1 38  ARG n 
1 39  GLN n 
1 40  ALA n 
1 41  PRO n 
1 42  GLY n 
1 43  GLN n 
1 44  GLY n 
1 45  LEU n 
1 46  GLU n 
1 47  TRP n 
1 48  MET n 
1 49  GLY n 
1 50  TRP n 
1 51  ILE n 
1 52  ASN n 
1 53  THR n 
1 54  TYR n 
1 55  THR n 
1 56  GLY n 
1 57  GLN n 
1 58  PRO n 
1 59  ILE n 
1 60  TYR n 
1 61  ALA n 
1 62  ASN n 
1 63  ASP n 
1 64  PHE n 
1 65  LYS n 
1 66  GLY n 
1 67  ARG n 
1 68  PHE n 
1 69  VAL n 
1 70  PHE n 
1 71  SER n 
1 72  LEU n 
1 73  ASP n 
1 74  THR n 
1 75  SER n 
1 76  VAL n 
1 77  SER n 
1 78  THR n 
1 79  ALA n 
1 80  TYR n 
1 81  LEU n 
1 82  GLN n 
1 83  ILE n 
1 84  SER n 
1 85  SER n 
1 86  LEU n 
1 87  LYS n 
1 88  ALA n 
1 89  GLU n 
1 90  ASP n 
1 91  THR n 
1 92  ALA n 
1 93  VAL n 
1 94  TYR n 
1 95  TYR n 
1 96  CYS n 
1 97  ALA n 
1 98  ARG n 
1 99  ASP n 
1 100 TRP n 
1 101 GLY n 
1 102 PRO n 
1 103 TYR n 
1 104 TRP n 
1 105 GLY n 
1 106 GLN n 
1 107 GLY n 
1 108 THR n 
1 109 LEU n 
1 110 VAL n 
1 111 THR n 
1 112 VAL n 
1 113 SER n 
1 114 SER n 
1 115 ALA n 
1 116 SER n 
1 117 THR n 
1 118 LYS n 
1 119 GLY n 
1 120 PRO n 
1 121 SER n 
1 122 VAL n 
1 123 PHE n 
1 124 PRO n 
1 125 LEU n 
1 126 ALA n 
1 127 PRO n 
1 128 SER n 
1 129 SER n 
1 130 LYS n 
1 131 SER n 
1 132 THR n 
1 133 SER n 
1 134 GLY n 
1 135 GLY n 
1 136 THR n 
1 137 ALA n 
1 138 ALA n 
1 139 LEU n 
1 140 GLY n 
1 141 CYS n 
1 142 LEU n 
1 143 VAL n 
1 144 LYS n 
1 145 ASP n 
1 146 TYR n 
1 147 PHE n 
1 148 PRO n 
1 149 GLU n 
1 150 PRO n 
1 151 VAL n 
1 152 THR n 
1 153 VAL n 
1 154 SER n 
1 155 TRP n 
1 156 ASN n 
1 157 SER n 
1 158 GLY n 
1 159 ALA n 
1 160 LEU n 
1 161 THR n 
1 162 SER n 
1 163 GLY n 
1 164 VAL n 
1 165 HIS n 
1 166 THR n 
1 167 PHE n 
1 168 PRO n 
1 169 ALA n 
1 170 VAL n 
1 171 LEU n 
1 172 GLN n 
1 173 SER n 
1 174 SER n 
1 175 GLY n 
1 176 LEU n 
1 177 TYR n 
1 178 SER n 
1 179 LEU n 
1 180 SER n 
1 181 SER n 
1 182 VAL n 
1 183 VAL n 
1 184 THR n 
1 185 VAL n 
1 186 PRO n 
1 187 SER n 
1 188 SER n 
1 189 SER n 
1 190 LEU n 
1 191 GLY n 
1 192 THR n 
1 193 GLN n 
1 194 THR n 
1 195 TYR n 
1 196 ILE n 
1 197 CYS n 
1 198 ASN n 
1 199 VAL n 
1 200 ASN n 
1 201 HIS n 
1 202 LYS n 
1 203 PRO n 
1 204 SER n 
1 205 ASN n 
1 206 THR n 
1 207 LYS n 
1 208 VAL n 
1 209 ASP n 
1 210 LYS n 
1 211 ARG n 
1 212 VAL n 
1 213 GLU n 
1 214 PRO n 
1 215 LYS n 
1 216 SER n 
1 217 CYS n 
1 218 ASP n 
1 219 LYS n 
2 1   ASP n 
2 2   ILE n 
2 3   VAL n 
2 4   MET n 
2 5   THR n 
2 6   GLN n 
2 7   SER n 
2 8   PRO n 
2 9   ASP n 
2 10  SER n 
2 11  LEU n 
2 12  ALA n 
2 13  VAL n 
2 14  SER n 
2 15  LEU n 
2 16  GLY n 
2 17  GLU n 
2 18  ARG n 
2 19  ALA n 
2 20  THR n 
2 21  ILE n 
2 22  ASN n 
2 23  CYS n 
2 24  LYS n 
2 25  SER n 
2 26  SER n 
2 27  GLN n 
2 28  SER n 
2 29  VAL n 
2 30  LEU n 
2 31  TYR n 
2 32  SER n 
2 33  SER n 
2 34  ASN n 
2 35  GLN n 
2 36  MET n 
2 37  ASN n 
2 38  TYR n 
2 39  LEU n 
2 40  ALA n 
2 41  TRP n 
2 42  TYR n 
2 43  GLN n 
2 44  GLN n 
2 45  LYS n 
2 46  PRO n 
2 47  GLY n 
2 48  GLN n 
2 49  PRO n 
2 50  PRO n 
2 51  LYS n 
2 52  LEU n 
2 53  LEU n 
2 54  ILE n 
2 55  TYR n 
2 56  TRP n 
2 57  ALA n 
2 58  SER n 
2 59  THR n 
2 60  ARG n 
2 61  GLU n 
2 62  SER n 
2 63  GLY n 
2 64  VAL n 
2 65  PRO n 
2 66  ASP n 
2 67  ARG n 
2 68  PHE n 
2 69  SER n 
2 70  GLY n 
2 71  SER n 
2 72  GLY n 
2 73  SER n 
2 74  GLY n 
2 75  THR n 
2 76  ASP n 
2 77  PHE n 
2 78  THR n 
2 79  LEU n 
2 80  THR n 
2 81  ILE n 
2 82  SER n 
2 83  SER n 
2 84  LEU n 
2 85  GLN n 
2 86  ALA n 
2 87  GLU n 
2 88  ASP n 
2 89  VAL n 
2 90  ALA n 
2 91  VAL n 
2 92  TYR n 
2 93  TYR n 
2 94  CYS n 
2 95  LEU n 
2 96  GLN n 
2 97  TYR n 
2 98  LEU n 
2 99  SER n 
2 100 SER n 
2 101 TRP n 
2 102 THR n 
2 103 PHE n 
2 104 GLY n 
2 105 GLY n 
2 106 GLY n 
2 107 THR n 
2 108 LYS n 
2 109 LEU n 
2 110 GLU n 
2 111 ILE n 
2 112 LYS n 
2 113 ARG n 
2 114 THR n 
2 115 VAL n 
2 116 ALA n 
2 117 ALA n 
2 118 PRO n 
2 119 SER n 
2 120 VAL n 
2 121 PHE n 
2 122 ILE n 
2 123 PHE n 
2 124 PRO n 
2 125 PRO n 
2 126 SER n 
2 127 ASP n 
2 128 GLU n 
2 129 GLN n 
2 130 LEU n 
2 131 LYS n 
2 132 SER n 
2 133 GLY n 
2 134 THR n 
2 135 ALA n 
2 136 SER n 
2 137 VAL n 
2 138 VAL n 
2 139 CYS n 
2 140 LEU n 
2 141 LEU n 
2 142 ASN n 
2 143 ASN n 
2 144 PHE n 
2 145 TYR n 
2 146 PRO n 
2 147 ARG n 
2 148 GLU n 
2 149 ALA n 
2 150 LYS n 
2 151 VAL n 
2 152 GLN n 
2 153 TRP n 
2 154 LYS n 
2 155 VAL n 
2 156 ASP n 
2 157 ASN n 
2 158 ALA n 
2 159 LEU n 
2 160 GLN n 
2 161 SER n 
2 162 GLY n 
2 163 ASN n 
2 164 SER n 
2 165 GLN n 
2 166 GLU n 
2 167 SER n 
2 168 VAL n 
2 169 THR n 
2 170 GLU n 
2 171 GLN n 
2 172 ASP n 
2 173 SER n 
2 174 LYS n 
2 175 ASP n 
2 176 SER n 
2 177 THR n 
2 178 TYR n 
2 179 SER n 
2 180 LEU n 
2 181 SER n 
2 182 SER n 
2 183 THR n 
2 184 LEU n 
2 185 THR n 
2 186 LEU n 
2 187 SER n 
2 188 LYS n 
2 189 ALA n 
2 190 ASP n 
2 191 TYR n 
2 192 GLU n 
2 193 LYS n 
2 194 HIS n 
2 195 LYS n 
2 196 LEU n 
2 197 TYR n 
2 198 ALA n 
2 199 CYS n 
2 200 GLU n 
2 201 VAL n 
2 202 THR n 
2 203 HIS n 
2 204 GLN n 
2 205 GLY n 
2 206 LEU n 
2 207 SER n 
2 208 SER n 
2 209 PRO n 
2 210 VAL n 
2 211 THR n 
2 212 LYS n 
2 213 SER n 
2 214 PHE n 
2 215 ASN n 
2 216 ARG n 
2 217 GLY n 
2 218 GLU n 
2 219 CYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 219 ? ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Cricetulus griseus' 10029 ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 219 ? ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Cricetulus griseus' 10029 ? ? ? ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?          'C3 H7 N O2'     89.093   
ARG 'L-peptide linking' y ARGININE ?          'C6 H15 N4 O2 1' 175.209  
ASN 'L-peptide linking' y ASPARAGINE ?          'C4 H8 N2 O3'    132.118  
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?          'C4 H7 N O4'     133.103  
CYS 'L-peptide linking' y CYSTEINE ?          'C3 H7 N O2 S'   121.158  
GLN 'L-peptide linking' y GLUTAMINE ?          'C5 H10 N2 O3'   146.144  
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?          'C5 H9 N O4'     147.129  
GLY 'peptide linking'   y GLYCINE ?          'C2 H5 N O2'     75.067   
HIS 'L-peptide linking' y HISTIDINE ?          'C6 H10 N3 O2 1' 156.162  
HOH non-polymer         . WATER ?          'H2 O'           18.015   
ILE 'L-peptide linking' y ISOLEUCINE ?          'C6 H13 N O2'    131.173  
IPA non-polymer         . 'ISOPROPYL ALCOHOL' 2-PROPANOL 'C3 H8 O'        60.095   
LEU 'L-peptide linking' y LEUCINE ?          'C6 H13 N O2'    131.173  
LYS 'L-peptide linking' y LYSINE ?          'C6 H15 N2 O2 1' 147.195  
MET 'L-peptide linking' y METHIONINE ?          'C5 H11 N O2 S'  149.211  
PEU non-polymer         . 
2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL 'PEG 8000' 
'C55 H112 O28'   1221.461 
PHE 'L-peptide linking' y PHENYLALANINE ?          'C9 H11 N O2'    165.189  
PRO 'L-peptide linking' y PROLINE ?          'C5 H9 N O2'     115.130  
SER 'L-peptide linking' y SERINE ?          'C3 H7 N O3'     105.093  
THR 'L-peptide linking' y THREONINE ?          'C4 H9 N O3'     119.119  
TRP 'L-peptide linking' y TRYPTOPHAN ?          'C11 H12 N2 O2'  204.225  
TYR 'L-peptide linking' y TYROSINE ?          'C9 H11 N O3'    181.189  
VAL 'L-peptide linking' y VALINE ?          'C5 H11 N O2'    117.146  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLN 1   1   1   GLN GLN A . n 
A 1 2   VAL 2   2   2   VAL VAL A . n 
A 1 3   GLN 3   3   3   GLN GLN A . n 
A 1 4   LEU 4   4   4   LEU LEU A . n 
A 1 5   VAL 5   5   5   VAL VAL A . n 
A 1 6   GLN 6   6   6   GLN GLN A . n 
A 1 7   SER 7   7   7   SER SER A . n 
A 1 8   GLY 8   8   8   GLY GLY A . n 
A 1 9   SER 9   9   9   SER SER A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  LEU 11  11  11  LEU LEU A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  LYS 13  13  13  LYS LYS A . n 
A 1 14  PRO 14  14  14  PRO PRO A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  ALA 16  16  16  ALA ALA A . n 
A 1 17  SER 17  17  17  SER SER A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  LYS 19  19  19  LYS LYS A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  LYS 23  23  23  LYS LYS A . n 
A 1 24  ALA 24  24  24  ALA ALA A . n 
A 1 25  SER 25  25  25  SER SER A . n 
A 1 26  GLY 26  26  26  GLY GLY A . n 
A 1 27  TYR 27  27  27  TYR TYR A . n 
A 1 28  THR 28  28  28  THR THR A . n 
A 1 29  PHE 29  29  29  PHE PHE A . n 
A 1 30  THR 30  30  30  THR THR A . n 
A 1 31  ASN 31  31  31  ASN ASN A . n 
A 1 32  TYR 32  32  32  TYR TYR A . n 
A 1 33  GLY 33  33  33  GLY GLY A . n 
A 1 34  MET 34  34  34  MET MET A . n 
A 1 35  ASN 35  35  35  ASN ASN A . n 
A 1 36  TRP 36  36  36  TRP TRP A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  GLN 39  39  39  GLN GLN A . n 
A 1 40  ALA 40  40  40  ALA ALA A . n 
A 1 41  PRO 41  41  41  PRO PRO A . n 
A 1 42  GLY 42  42  42  GLY GLY A . n 
A 1 43  GLN 43  43  43  GLN GLN A . n 
A 1 44  GLY 44  44  44  GLY GLY A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  TRP 47  47  47  TRP TRP A . n 
A 1 48  MET 48  48  48  MET MET A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  TRP 50  50  50  TRP TRP A . n 
A 1 51  ILE 51  51  51  ILE ILE A . n 
A 1 52  ASN 52  52  52  ASN ASN A . n 
A 1 53  THR 53  53  53  THR THR A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  THR 55  55  55  THR THR A . n 
A 1 56  GLY 56  56  56  GLY GLY A . n 
A 1 57  GLN 57  57  57  GLN GLN A . n 
A 1 58  PRO 58  58  58  PRO PRO A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  TYR 60  60  60  TYR TYR A . n 
A 1 61  ALA 61  61  61  ALA ALA A . n 
A 1 62  ASN 62  62  62  ASN ASN A . n 
A 1 63  ASP 63  63  63  ASP ASP A . n 
A 1 64  PHE 64  64  64  PHE PHE A . n 
A 1 65  LYS 65  65  65  LYS LYS A . n 
A 1 66  GLY 66  66  66  GLY GLY A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  PHE 68  68  68  PHE PHE A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  PHE 70  70  70  PHE PHE A . n 
A 1 71  SER 71  71  71  SER SER A . n 
A 1 72  LEU 72  72  72  LEU LEU A . n 
A 1 73  ASP 73  73  73  ASP ASP A . n 
A 1 74  THR 74  74  74  THR THR A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  VAL 76  76  76  VAL VAL A . n 
A 1 77  SER 77  77  77  SER SER A . n 
A 1 78  THR 78  78  78  THR THR A . n 
A 1 79  ALA 79  79  79  ALA ALA A . n 
A 1 80  TYR 80  80  80  TYR TYR A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  GLN 82  82  82  GLN GLN A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  SER 84  84  84  SER SER A . n 
A 1 85  SER 85  85  85  SER SER A . n 
A 1 86  LEU 86  86  86  LEU LEU A . n 
A 1 87  LYS 87  87  87  LYS LYS A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  ASP 90  90  90  ASP ASP A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  ALA 92  92  92  ALA ALA A . n 
A 1 93  VAL 93  93  93  VAL VAL A . n 
A 1 94  TYR 94  94  94  TYR TYR A . n 
A 1 95  TYR 95  95  95  TYR TYR A . n 
A 1 96  CYS 96  96  96  CYS CYS A . n 
A 1 97  ALA 97  97  97  ALA ALA A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  ASP 99  99  99  ASP ASP A . n 
A 1 100 TRP 100 100 100 TRP TRP A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 PRO 102 102 102 PRO PRO A . n 
A 1 103 TYR 103 103 103 TYR TYR A . n 
A 1 104 TRP 104 104 104 TRP TRP A . n 
A 1 105 GLY 105 105 105 GLY GLY A . n 
A 1 106 GLN 106 106 106 GLN GLN A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 THR 108 108 108 THR THR A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 VAL 110 110 110 VAL VAL A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 SER 114 114 114 SER SER A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 SER 116 116 116 SER SER A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 LYS 118 118 118 LYS LYS A . n 
A 1 119 GLY 119 119 119 GLY GLY A . n 
A 1 120 PRO 120 120 120 PRO PRO A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 VAL 122 122 122 VAL VAL A . n 
A 1 123 PHE 123 123 123 PHE PHE A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 LEU 125 125 125 LEU LEU A . n 
A 1 126 ALA 126 126 126 ALA ALA A . n 
A 1 127 PRO 127 127 127 PRO PRO A . n 
A 1 128 SER 128 128 128 SER SER A . n 
A 1 129 SER 129 129 129 SER SER A . n 
A 1 130 LYS 130 130 ?   ?   ?   A . n 
A 1 131 SER 131 131 ?   ?   ?   A . n 
A 1 132 THR 132 132 ?   ?   ?   A . n 
A 1 133 SER 133 133 ?   ?   ?   A . n 
A 1 134 GLY 134 134 ?   ?   ?   A . n 
A 1 135 GLY 135 135 135 GLY GLY A . n 
A 1 136 THR 136 136 136 THR THR A . n 
A 1 137 ALA 137 137 137 ALA ALA A . n 
A 1 138 ALA 138 138 138 ALA ALA A . n 
A 1 139 LEU 139 139 139 LEU LEU A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 CYS 141 141 141 CYS CYS A . n 
A 1 142 LEU 142 142 142 LEU LEU A . n 
A 1 143 VAL 143 143 143 VAL VAL A . n 
A 1 144 LYS 144 144 144 LYS LYS A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 TYR 146 146 146 TYR TYR A . n 
A 1 147 PHE 147 147 147 PHE PHE A . n 
A 1 148 PRO 148 148 148 PRO PRO A . n 
A 1 149 GLU 149 149 149 GLU GLU A . n 
A 1 150 PRO 150 150 150 PRO PRO A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 THR 152 152 152 THR THR A . n 
A 1 153 VAL 153 153 153 VAL VAL A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 TRP 155 155 155 TRP TRP A . n 
A 1 156 ASN 156 156 156 ASN ASN A . n 
A 1 157 SER 157 157 157 SER SER A . n 
A 1 158 GLY 158 158 158 GLY GLY A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 LEU 160 160 160 LEU LEU A . n 
A 1 161 THR 161 161 161 THR THR A . n 
A 1 162 SER 162 162 162 SER SER A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 VAL 164 164 164 VAL VAL A . n 
A 1 165 HIS 165 165 165 HIS HIS A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 PHE 167 167 167 PHE PHE A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 ALA 169 169 169 ALA ALA A . n 
A 1 170 VAL 170 170 170 VAL VAL A . n 
A 1 171 LEU 171 171 171 LEU LEU A . n 
A 1 172 GLN 172 172 172 GLN GLN A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 SER 174 174 174 SER SER A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 LEU 176 176 176 LEU LEU A . n 
A 1 177 TYR 177 177 177 TYR TYR A . n 
A 1 178 SER 178 178 178 SER SER A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 SER 180 180 180 SER SER A . n 
A 1 181 SER 181 181 181 SER SER A . n 
A 1 182 VAL 182 182 182 VAL VAL A . n 
A 1 183 VAL 183 183 183 VAL VAL A . n 
A 1 184 THR 184 184 184 THR THR A . n 
A 1 185 VAL 185 185 185 VAL VAL A . n 
A 1 186 PRO 186 186 186 PRO PRO A . n 
A 1 187 SER 187 187 187 SER SER A . n 
A 1 188 SER 188 188 188 SER SER A . n 
A 1 189 SER 189 189 189 SER SER A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 GLY 191 191 191 GLY GLY A . n 
A 1 192 THR 192 192 192 THR THR A . n 
A 1 193 GLN 193 193 193 GLN GLN A . n 
A 1 194 THR 194 194 194 THR THR A . n 
A 1 195 TYR 195 195 195 TYR TYR A . n 
A 1 196 ILE 196 196 196 ILE ILE A . n 
A 1 197 CYS 197 197 197 CYS CYS A . n 
A 1 198 ASN 198 198 198 ASN ASN A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 ASN 200 200 200 ASN ASN A . n 
A 1 201 HIS 201 201 201 HIS HIS A . n 
A 1 202 LYS 202 202 202 LYS LYS A . n 
A 1 203 PRO 203 203 203 PRO PRO A . n 
A 1 204 SER 204 204 204 SER SER A . n 
A 1 205 ASN 205 205 205 ASN ASN A . n 
A 1 206 THR 206 206 206 THR THR A . n 
A 1 207 LYS 207 207 207 LYS LYS A . n 
A 1 208 VAL 208 208 208 VAL VAL A . n 
A 1 209 ASP 209 209 209 ASP ASP A . n 
A 1 210 LYS 210 210 210 LYS LYS A . n 
A 1 211 ARG 211 211 211 ARG ARG A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 GLU 213 213 213 GLU GLU A . n 
A 1 214 PRO 214 214 214 PRO PRO A . n 
A 1 215 LYS 215 215 ?   ?   ?   A . n 
A 1 216 SER 216 216 ?   ?   ?   A . n 
A 1 217 CYS 217 217 ?   ?   ?   A . n 
A 1 218 ASP 218 218 ?   ?   ?   A . n 
A 1 219 LYS 219 219 ?   ?   ?   A . n 
B 2 1   ASP 1   1   1   ASP ASP B . n 
B 2 2   ILE 2   2   2   ILE ILE B . n 
B 2 3   VAL 3   3   3   VAL VAL B . n 
B 2 4   MET 4   4   4   MET MET B . n 
B 2 5   THR 5   5   5   THR THR B . n 
B 2 6   GLN 6   6   6   GLN GLN B . n 
B 2 7   SER 7   7   7   SER SER B . n 
B 2 8   PRO 8   8   8   PRO PRO B . n 
B 2 9   ASP 9   9   9   ASP ASP B . n 
B 2 10  SER 10  10  10  SER SER B . n 
B 2 11  LEU 11  11  11  LEU LEU B . n 
B 2 12  ALA 12  12  12  ALA ALA B . n 
B 2 13  VAL 13  13  13  VAL VAL B . n 
B 2 14  SER 14  14  14  SER SER B . n 
B 2 15  LEU 15  15  15  LEU LEU B . n 
B 2 16  GLY 16  16  16  GLY GLY B . n 
B 2 17  GLU 17  17  17  GLU GLU B . n 
B 2 18  ARG 18  18  18  ARG ARG B . n 
B 2 19  ALA 19  19  19  ALA ALA B . n 
B 2 20  THR 20  20  20  THR THR B . n 
B 2 21  ILE 21  21  21  ILE ILE B . n 
B 2 22  ASN 22  22  22  ASN ASN B . n 
B 2 23  CYS 23  23  23  CYS CYS B . n 
B 2 24  LYS 24  24  24  LYS LYS B . n 
B 2 25  SER 25  25  25  SER SER B . n 
B 2 26  SER 26  26  26  SER SER B . n 
B 2 27  GLN 27  27  27  GLN GLN B . n 
B 2 28  SER 28  28  28  SER SER B . n 
B 2 29  VAL 29  29  29  VAL VAL B . n 
B 2 30  LEU 30  30  30  LEU LEU B . n 
B 2 31  TYR 31  31  31  TYR TYR B . n 
B 2 32  SER 32  32  32  SER SER B . n 
B 2 33  SER 33  33  33  SER SER B . n 
B 2 34  ASN 34  34  34  ASN ASN B . n 
B 2 35  GLN 35  35  35  GLN GLN B . n 
B 2 36  MET 36  36  36  MET MET B . n 
B 2 37  ASN 37  37  37  ASN ASN B . n 
B 2 38  TYR 38  38  38  TYR TYR B . n 
B 2 39  LEU 39  39  39  LEU LEU B . n 
B 2 40  ALA 40  40  40  ALA ALA B . n 
B 2 41  TRP 41  41  41  TRP TRP B . n 
B 2 42  TYR 42  42  42  TYR TYR B . n 
B 2 43  GLN 43  43  43  GLN GLN B . n 
B 2 44  GLN 44  44  44  GLN GLN B . n 
B 2 45  LYS 45  45  45  LYS LYS B . n 
B 2 46  PRO 46  46  46  PRO PRO B . n 
B 2 47  GLY 47  47  47  GLY GLY B . n 
B 2 48  GLN 48  48  48  GLN GLN B . n 
B 2 49  PRO 49  49  49  PRO PRO B . n 
B 2 50  PRO 50  50  50  PRO PRO B . n 
B 2 51  LYS 51  51  51  LYS LYS B . n 
B 2 52  LEU 52  52  52  LEU LEU B . n 
B 2 53  LEU 53  53  53  LEU LEU B . n 
B 2 54  ILE 54  54  54  ILE ILE B . n 
B 2 55  TYR 55  55  55  TYR TYR B . n 
B 2 56  TRP 56  56  56  TRP TRP B . n 
B 2 57  ALA 57  57  57  ALA ALA B . n 
B 2 58  SER 58  58  58  SER SER B . n 
B 2 59  THR 59  59  59  THR THR B . n 
B 2 60  ARG 60  60  60  ARG ARG B . n 
B 2 61  GLU 61  61  61  GLU GLU B . n 
B 2 62  SER 62  62  62  SER SER B . n 
B 2 63  GLY 63  63  63  GLY GLY B . n 
B 2 64  VAL 64  64  64  VAL VAL B . n 
B 2 65  PRO 65  65  65  PRO PRO B . n 
B 2 66  ASP 66  66  66  ASP ASP B . n 
B 2 67  ARG 67  67  67  ARG ARG B . n 
B 2 68  PHE 68  68  68  PHE PHE B . n 
B 2 69  SER 69  69  69  SER SER B . n 
B 2 70  GLY 70  70  70  GLY GLY B . n 
B 2 71  SER 71  71  71  SER SER B . n 
B 2 72  GLY 72  72  72  GLY GLY B . n 
B 2 73  SER 73  73  73  SER SER B . n 
B 2 74  GLY 74  74  74  GLY GLY B . n 
B 2 75  THR 75  75  75  THR THR B . n 
B 2 76  ASP 76  76  76  ASP ASP B . n 
B 2 77  PHE 77  77  77  PHE PHE B . n 
B 2 78  THR 78  78  78  THR THR B . n 
B 2 79  LEU 79  79  79  LEU LEU B . n 
B 2 80  THR 80  80  80  THR THR B . n 
B 2 81  ILE 81  81  81  ILE ILE B . n 
B 2 82  SER 82  82  82  SER SER B . n 
B 2 83  SER 83  83  83  SER SER B . n 
B 2 84  LEU 84  84  84  LEU LEU B . n 
B 2 85  GLN 85  85  85  GLN GLN B . n 
B 2 86  ALA 86  86  86  ALA ALA B . n 
B 2 87  GLU 87  87  87  GLU GLU B . n 
B 2 88  ASP 88  88  88  ASP ASP B . n 
B 2 89  VAL 89  89  89  VAL VAL B . n 
B 2 90  ALA 90  90  90  ALA ALA B . n 
B 2 91  VAL 91  91  91  VAL VAL B . n 
B 2 92  TYR 92  92  92  TYR TYR B . n 
B 2 93  TYR 93  93  93  TYR TYR B . n 
B 2 94  CYS 94  94  94  CYS CYS B . n 
B 2 95  LEU 95  95  95  LEU LEU B . n 
B 2 96  GLN 96  96  96  GLN GLN B . n 
B 2 97  TYR 97  97  97  TYR TYR B . n 
B 2 98  LEU 98  98  98  LEU LEU B . n 
B 2 99  SER 99  99  99  SER SER B . n 
B 2 100 SER 100 100 100 SER SER B . n 
B 2 101 TRP 101 101 101 TRP TRP B . n 
B 2 102 THR 102 102 102 THR THR B . n 
B 2 103 PHE 103 103 103 PHE PHE B . n 
B 2 104 GLY 104 104 104 GLY GLY B . n 
B 2 105 GLY 105 105 105 GLY GLY B . n 
B 2 106 GLY 106 106 106 GLY GLY B . n 
B 2 107 THR 107 107 107 THR THR B . n 
B 2 108 LYS 108 108 108 LYS LYS B . n 
B 2 109 LEU 109 109 109 LEU LEU B . n 
B 2 110 GLU 110 110 110 GLU GLU B . n 
B 2 111 ILE 111 111 111 ILE ILE B . n 
B 2 112 LYS 112 112 112 LYS LYS B . n 
B 2 113 ARG 113 113 113 ARG ARG B . n 
B 2 114 THR 114 114 114 THR THR B . n 
B 2 115 VAL 115 115 115 VAL VAL B . n 
B 2 116 ALA 116 116 116 ALA ALA B . n 
B 2 117 ALA 117 117 117 ALA ALA B . n 
B 2 118 PRO 118 118 118 PRO PRO B . n 
B 2 119 SER 119 119 119 SER SER B . n 
B 2 120 VAL 120 120 120 VAL VAL B . n 
B 2 121 PHE 121 121 121 PHE PHE B . n 
B 2 122 ILE 122 122 122 ILE ILE B . n 
B 2 123 PHE 123 123 123 PHE PHE B . n 
B 2 124 PRO 124 124 124 PRO PRO B . n 
B 2 125 PRO 125 125 125 PRO PRO B . n 
B 2 126 SER 126 126 126 SER SER B . n 
B 2 127 ASP 127 127 127 ASP ASP B . n 
B 2 128 GLU 128 128 128 GLU GLU B . n 
B 2 129 GLN 129 129 129 GLN GLN B . n 
B 2 130 LEU 130 130 130 LEU LEU B . n 
B 2 131 LYS 131 131 131 LYS LYS B . n 
B 2 132 SER 132 132 132 SER SER B . n 
B 2 133 GLY 133 133 133 GLY GLY B . n 
B 2 134 THR 134 134 134 THR THR B . n 
B 2 135 ALA 135 135 135 ALA ALA B . n 
B 2 136 SER 136 136 136 SER SER B . n 
B 2 137 VAL 137 137 137 VAL VAL B . n 
B 2 138 VAL 138 138 138 VAL VAL B . n 
B 2 139 CYS 139 139 139 CYS CYS B . n 
B 2 140 LEU 140 140 140 LEU LEU B . n 
B 2 141 LEU 141 141 141 LEU LEU B . n 
B 2 142 ASN 142 142 142 ASN ASN B . n 
B 2 143 ASN 143 143 143 ASN ASN B . n 
B 2 144 PHE 144 144 144 PHE PHE B . n 
B 2 145 TYR 145 145 145 TYR TYR B . n 
B 2 146 PRO 146 146 146 PRO PRO B . n 
B 2 147 ARG 147 147 147 ARG ARG B . n 
B 2 148 GLU 148 148 148 GLU GLU B . n 
B 2 149 ALA 149 149 149 ALA ALA B . n 
B 2 150 LYS 150 150 150 LYS LYS B . n 
B 2 151 VAL 151 151 151 VAL VAL B . n 
B 2 152 GLN 152 152 152 GLN GLN B . n 
B 2 153 TRP 153 153 153 TRP TRP B . n 
B 2 154 LYS 154 154 154 LYS LYS B . n 
B 2 155 VAL 155 155 155 VAL VAL B . n 
B 2 156 ASP 156 156 156 ASP ASP B . n 
B 2 157 ASN 157 157 157 ASN ASN B . n 
B 2 158 ALA 158 158 158 ALA ALA B . n 
B 2 159 LEU 159 159 159 LEU LEU B . n 
B 2 160 GLN 160 160 160 GLN GLN B . n 
B 2 161 SER 161 161 161 SER SER B . n 
B 2 162 GLY 162 162 162 GLY GLY B . n 
B 2 163 ASN 163 163 163 ASN ASN B . n 
B 2 164 SER 164 164 164 SER SER B . n 
B 2 165 GLN 165 165 165 GLN GLN B . n 
B 2 166 GLU 166 166 166 GLU GLU B . n 
B 2 167 SER 167 167 167 SER SER B . n 
B 2 168 VAL 168 168 168 VAL VAL B . n 
B 2 169 THR 169 169 169 THR THR B . n 
B 2 170 GLU 170 170 170 GLU GLU B . n 
B 2 171 GLN 171 171 171 GLN GLN B . n 
B 2 172 ASP 172 172 172 ASP ASP B . n 
B 2 173 SER 173 173 173 SER SER B . n 
B 2 174 LYS 174 174 174 LYS LYS B . n 
B 2 175 ASP 175 175 175 ASP ASP B . n 
B 2 176 SER 176 176 176 SER SER B . n 
B 2 177 THR 177 177 177 THR THR B . n 
B 2 178 TYR 178 178 178 TYR TYR B . n 
B 2 179 SER 179 179 179 SER SER B . n 
B 2 180 LEU 180 180 180 LEU LEU B . n 
B 2 181 SER 181 181 181 SER SER B . n 
B 2 182 SER 182 182 182 SER SER B . n 
B 2 183 THR 183 183 183 THR THR B . n 
B 2 184 LEU 184 184 184 LEU LEU B . n 
B 2 185 THR 185 185 185 THR THR B . n 
B 2 186 LEU 186 186 186 LEU LEU B . n 
B 2 187 SER 187 187 187 SER SER B . n 
B 2 188 LYS 188 188 188 LYS LYS B . n 
B 2 189 ALA 189 189 189 ALA ALA B . n 
B 2 190 ASP 190 190 190 ASP ASP B . n 
B 2 191 TYR 191 191 191 TYR TYR B . n 
B 2 192 GLU 192 192 192 GLU GLU B . n 
B 2 193 LYS 193 193 193 LYS LYS B . n 
B 2 194 HIS 194 194 194 HIS HIS B . n 
B 2 195 LYS 195 195 195 LYS LYS B . n 
B 2 196 LEU 196 196 196 LEU LEU B . n 
B 2 197 TYR 197 197 197 TYR TYR B . n 
B 2 198 ALA 198 198 198 ALA ALA B . n 
B 2 199 CYS 199 199 199 CYS CYS B . n 
B 2 200 GLU 200 200 200 GLU GLU B . n 
B 2 201 VAL 201 201 201 VAL VAL B . n 
B 2 202 THR 202 202 202 THR THR B . n 
B 2 203 HIS 203 203 203 HIS HIS B . n 
B 2 204 GLN 204 204 204 GLN GLN B . n 
B 2 205 GLY 205 205 205 GLY GLY B . n 
B 2 206 LEU 206 206 206 LEU LEU B . n 
B 2 207 SER 207 207 207 SER SER B . n 
B 2 208 SER 208 208 208 SER SER B . n 
B 2 209 PRO 209 209 209 PRO PRO B . n 
B 2 210 VAL 210 210 210 VAL VAL B . n 
B 2 211 THR 211 211 211 THR THR B . n 
B 2 212 LYS 212 212 212 LYS LYS B . n 
B 2 213 SER 213 213 213 SER SER B . n 
B 2 214 PHE 214 214 214 PHE PHE B . n 
B 2 215 ASN 215 215 215 ASN ASN B . n 
B 2 216 ARG 216 216 216 ARG ARG B . n 
B 2 217 GLY 217 217 217 GLY GLY B . n 
B 2 218 GLU 218 218 ?   ?   ?   B . n 
B 2 219 CYS 219 219 ?   ?   ?   B . n 
C 1 1   GLN 1   1   1   GLN GLN H . n 
C 1 2   VAL 2   2   2   VAL VAL H . n 
C 1 3   GLN 3   3   3   GLN GLN H . n 
C 1 4   LEU 4   4   4   LEU LEU H . n 
C 1 5   VAL 5   5   5   VAL VAL H . n 
C 1 6   GLN 6   6   6   GLN GLN H . n 
C 1 7   SER 7   7   7   SER SER H . n 
C 1 8   GLY 8   8   8   GLY GLY H . n 
C 1 9   SER 9   9   9   SER SER H . n 
C 1 10  GLU 10  10  10  GLU GLU H . n 
C 1 11  LEU 11  11  11  LEU LEU H . n 
C 1 12  LYS 12  12  12  LYS LYS H . n 
C 1 13  LYS 13  13  13  LYS LYS H . n 
C 1 14  PRO 14  14  14  PRO PRO H . n 
C 1 15  GLY 15  15  15  GLY GLY H . n 
C 1 16  ALA 16  16  16  ALA ALA H . n 
C 1 17  SER 17  17  17  SER SER H . n 
C 1 18  VAL 18  18  18  VAL VAL H . n 
C 1 19  LYS 19  19  19  LYS LYS H . n 
C 1 20  VAL 20  20  20  VAL VAL H . n 
C 1 21  SER 21  21  21  SER SER H . n 
C 1 22  CYS 22  22  22  CYS CYS H . n 
C 1 23  LYS 23  23  23  LYS LYS H . n 
C 1 24  ALA 24  24  24  ALA ALA H . n 
C 1 25  SER 25  25  25  SER SER H . n 
C 1 26  GLY 26  26  26  GLY GLY H . n 
C 1 27  TYR 27  27  27  TYR TYR H . n 
C 1 28  THR 28  28  28  THR THR H . n 
C 1 29  PHE 29  29  29  PHE PHE H . n 
C 1 30  THR 30  30  30  THR THR H . n 
C 1 31  ASN 31  31  31  ASN ASN H . n 
C 1 32  TYR 32  32  32  TYR TYR H . n 
C 1 33  GLY 33  33  33  GLY GLY H . n 
C 1 34  MET 34  34  34  MET MET H . n 
C 1 35  ASN 35  35  35  ASN ASN H . n 
C 1 36  TRP 36  36  36  TRP TRP H . n 
C 1 37  VAL 37  37  37  VAL VAL H . n 
C 1 38  ARG 38  38  38  ARG ARG H . n 
C 1 39  GLN 39  39  39  GLN GLN H . n 
C 1 40  ALA 40  40  40  ALA ALA H . n 
C 1 41  PRO 41  41  41  PRO PRO H . n 
C 1 42  GLY 42  42  42  GLY GLY H . n 
C 1 43  GLN 43  43  43  GLN GLN H . n 
C 1 44  GLY 44  44  44  GLY GLY H . n 
C 1 45  LEU 45  45  45  LEU LEU H . n 
C 1 46  GLU 46  46  46  GLU GLU H . n 
C 1 47  TRP 47  47  47  TRP TRP H . n 
C 1 48  MET 48  48  48  MET MET H . n 
C 1 49  GLY 49  49  49  GLY GLY H . n 
C 1 50  TRP 50  50  50  TRP TRP H . n 
C 1 51  ILE 51  51  51  ILE ILE H . n 
C 1 52  ASN 52  52  52  ASN ASN H . n 
C 1 53  THR 53  53  53  THR THR H . n 
C 1 54  TYR 54  54  54  TYR TYR H . n 
C 1 55  THR 55  55  55  THR THR H . n 
C 1 56  GLY 56  56  56  GLY GLY H . n 
C 1 57  GLN 57  57  57  GLN GLN H . n 
C 1 58  PRO 58  58  58  PRO PRO H . n 
C 1 59  ILE 59  59  59  ILE ILE H . n 
C 1 60  TYR 60  60  60  TYR TYR H . n 
C 1 61  ALA 61  61  61  ALA ALA H . n 
C 1 62  ASN 62  62  62  ASN ASN H . n 
C 1 63  ASP 63  63  63  ASP ASP H . n 
C 1 64  PHE 64  64  64  PHE PHE H . n 
C 1 65  LYS 65  65  65  LYS LYS H . n 
C 1 66  GLY 66  66  66  GLY GLY H . n 
C 1 67  ARG 67  67  67  ARG ARG H . n 
C 1 68  PHE 68  68  68  PHE PHE H . n 
C 1 69  VAL 69  69  69  VAL VAL H . n 
C 1 70  PHE 70  70  70  PHE PHE H . n 
C 1 71  SER 71  71  71  SER SER H . n 
C 1 72  LEU 72  72  72  LEU LEU H . n 
C 1 73  ASP 73  73  73  ASP ASP H . n 
C 1 74  THR 74  74  74  THR THR H . n 
C 1 75  SER 75  75  75  SER SER H . n 
C 1 76  VAL 76  76  76  VAL VAL H . n 
C 1 77  SER 77  77  77  SER SER H . n 
C 1 78  THR 78  78  78  THR THR H . n 
C 1 79  ALA 79  79  79  ALA ALA H . n 
C 1 80  TYR 80  80  80  TYR TYR H . n 
C 1 81  LEU 81  81  81  LEU LEU H . n 
C 1 82  GLN 82  82  82  GLN GLN H . n 
C 1 83  ILE 83  83  83  ILE ILE H . n 
C 1 84  SER 84  84  84  SER SER H . n 
C 1 85  SER 85  85  85  SER SER H . n 
C 1 86  LEU 86  86  86  LEU LEU H . n 
C 1 87  LYS 87  87  87  LYS LYS H . n 
C 1 88  ALA 88  88  88  ALA ALA H . n 
C 1 89  GLU 89  89  89  GLU GLU H . n 
C 1 90  ASP 90  90  90  ASP ASP H . n 
C 1 91  THR 91  91  91  THR THR H . n 
C 1 92  ALA 92  92  92  ALA ALA H . n 
C 1 93  VAL 93  93  93  VAL VAL H . n 
C 1 94  TYR 94  94  94  TYR TYR H . n 
C 1 95  TYR 95  95  95  TYR TYR H . n 
C 1 96  CYS 96  96  96  CYS CYS H . n 
C 1 97  ALA 97  97  97  ALA ALA H . n 
C 1 98  ARG 98  98  98  ARG ARG H . n 
C 1 99  ASP 99  99  99  ASP ASP H . n 
C 1 100 TRP 100 100 100 TRP TRP H . n 
C 1 101 GLY 101 101 101 GLY GLY H . n 
C 1 102 PRO 102 102 102 PRO PRO H . n 
C 1 103 TYR 103 103 103 TYR TYR H . n 
C 1 104 TRP 104 104 104 TRP TRP H . n 
C 1 105 GLY 105 105 105 GLY GLY H . n 
C 1 106 GLN 106 106 106 GLN GLN H . n 
C 1 107 GLY 107 107 107 GLY GLY H . n 
C 1 108 THR 108 108 108 THR THR H . n 
C 1 109 LEU 109 109 109 LEU LEU H . n 
C 1 110 VAL 110 110 110 VAL VAL H . n 
C 1 111 THR 111 111 111 THR THR H . n 
C 1 112 VAL 112 112 112 VAL VAL H . n 
C 1 113 SER 113 113 113 SER SER H . n 
C 1 114 SER 114 114 114 SER SER H . n 
C 1 115 ALA 115 115 115 ALA ALA H . n 
C 1 116 SER 116 116 116 SER SER H . n 
C 1 117 THR 117 117 117 THR THR H . n 
C 1 118 LYS 118 118 118 LYS LYS H . n 
C 1 119 GLY 119 119 119 GLY GLY H . n 
C 1 120 PRO 120 120 120 PRO PRO H . n 
C 1 121 SER 121 121 121 SER SER H . n 
C 1 122 VAL 122 122 122 VAL VAL H . n 
C 1 123 PHE 123 123 123 PHE PHE H . n 
C 1 124 PRO 124 124 124 PRO PRO H . n 
C 1 125 LEU 125 125 125 LEU LEU H . n 
C 1 126 ALA 126 126 126 ALA ALA H . n 
C 1 127 PRO 127 127 127 PRO PRO H . n 
C 1 128 SER 128 128 128 SER SER H . n 
C 1 129 SER 129 129 129 SER SER H . n 
C 1 130 LYS 130 130 130 LYS LYS H . n 
C 1 131 SER 131 131 131 SER SER H . n 
C 1 132 THR 132 132 ?   ?   ?   H . n 
C 1 133 SER 133 133 ?   ?   ?   H . n 
C 1 134 GLY 134 134 ?   ?   ?   H . n 
C 1 135 GLY 135 135 135 GLY GLY H . n 
C 1 136 THR 136 136 136 THR THR H . n 
C 1 137 ALA 137 137 137 ALA ALA H . n 
C 1 138 ALA 138 138 138 ALA ALA H . n 
C 1 139 LEU 139 139 139 LEU LEU H . n 
C 1 140 GLY 140 140 140 GLY GLY H . n 
C 1 141 CYS 141 141 141 CYS CYS H . n 
C 1 142 LEU 142 142 142 LEU LEU H . n 
C 1 143 VAL 143 143 143 VAL VAL H . n 
C 1 144 LYS 144 144 144 LYS LYS H . n 
C 1 145 ASP 145 145 145 ASP ASP H . n 
C 1 146 TYR 146 146 146 TYR TYR H . n 
C 1 147 PHE 147 147 147 PHE PHE H . n 
C 1 148 PRO 148 148 148 PRO PRO H . n 
C 1 149 GLU 149 149 149 GLU GLU H . n 
C 1 150 PRO 150 150 150 PRO PRO H . n 
C 1 151 VAL 151 151 151 VAL VAL H . n 
C 1 152 THR 152 152 152 THR THR H . n 
C 1 153 VAL 153 153 153 VAL VAL H . n 
C 1 154 SER 154 154 154 SER SER H . n 
C 1 155 TRP 155 155 155 TRP TRP H . n 
C 1 156 ASN 156 156 156 ASN ASN H . n 
C 1 157 SER 157 157 157 SER SER H . n 
C 1 158 GLY 158 158 158 GLY GLY H . n 
C 1 159 ALA 159 159 159 ALA ALA H . n 
C 1 160 LEU 160 160 160 LEU LEU H . n 
C 1 161 THR 161 161 161 THR THR H . n 
C 1 162 SER 162 162 162 SER SER H . n 
C 1 163 GLY 163 163 163 GLY GLY H . n 
C 1 164 VAL 164 164 164 VAL VAL H . n 
C 1 165 HIS 165 165 165 HIS HIS H . n 
C 1 166 THR 166 166 166 THR THR H . n 
C 1 167 PHE 167 167 167 PHE PHE H . n 
C 1 168 PRO 168 168 168 PRO PRO H . n 
C 1 169 ALA 169 169 169 ALA ALA H . n 
C 1 170 VAL 170 170 170 VAL VAL H . n 
C 1 171 LEU 171 171 171 LEU LEU H . n 
C 1 172 GLN 172 172 172 GLN GLN H . n 
C 1 173 SER 173 173 173 SER SER H . n 
C 1 174 SER 174 174 174 SER SER H . n 
C 1 175 GLY 175 175 175 GLY GLY H . n 
C 1 176 LEU 176 176 176 LEU LEU H . n 
C 1 177 TYR 177 177 177 TYR TYR H . n 
C 1 178 SER 178 178 178 SER SER H . n 
C 1 179 LEU 179 179 179 LEU LEU H . n 
C 1 180 SER 180 180 180 SER SER H . n 
C 1 181 SER 181 181 181 SER SER H . n 
C 1 182 VAL 182 182 182 VAL VAL H . n 
C 1 183 VAL 183 183 183 VAL VAL H . n 
C 1 184 THR 184 184 184 THR THR H . n 
C 1 185 VAL 185 185 185 VAL VAL H . n 
C 1 186 PRO 186 186 186 PRO PRO H . n 
C 1 187 SER 187 187 187 SER SER H . n 
C 1 188 SER 188 188 188 SER SER H . n 
C 1 189 SER 189 189 189 SER SER H . n 
C 1 190 LEU 190 190 190 LEU LEU H . n 
C 1 191 GLY 191 191 191 GLY GLY H . n 
C 1 192 THR 192 192 192 THR THR H . n 
C 1 193 GLN 193 193 193 GLN GLN H . n 
C 1 194 THR 194 194 194 THR THR H . n 
C 1 195 TYR 195 195 195 TYR TYR H . n 
C 1 196 ILE 196 196 196 ILE ILE H . n 
C 1 197 CYS 197 197 197 CYS CYS H . n 
C 1 198 ASN 198 198 198 ASN ASN H . n 
C 1 199 VAL 199 199 199 VAL VAL H . n 
C 1 200 ASN 200 200 200 ASN ASN H . n 
C 1 201 HIS 201 201 201 HIS HIS H . n 
C 1 202 LYS 202 202 202 LYS LYS H . n 
C 1 203 PRO 203 203 203 PRO PRO H . n 
C 1 204 SER 204 204 204 SER SER H . n 
C 1 205 ASN 205 205 205 ASN ASN H . n 
C 1 206 THR 206 206 206 THR THR H . n 
C 1 207 LYS 207 207 207 LYS LYS H . n 
C 1 208 VAL 208 208 208 VAL VAL H . n 
C 1 209 ASP 209 209 209 ASP ASP H . n 
C 1 210 LYS 210 210 210 LYS LYS H . n 
C 1 211 ARG 211 211 211 ARG ARG H . n 
C 1 212 VAL 212 212 212 VAL VAL H . n 
C 1 213 GLU 213 213 213 GLU GLU H . n 
C 1 214 PRO 214 214 214 PRO PRO H . n 
C 1 215 LYS 215 215 215 LYS LYS H . n 
C 1 216 SER 216 216 ?   ?   ?   H . n 
C 1 217 CYS 217 217 ?   ?   ?   H . n 
C 1 218 ASP 218 218 ?   ?   ?   H . n 
C 1 219 LYS 219 219 ?   ?   ?   H . n 
D 2 1   ASP 1   1   1   ASP ASP L . n 
D 2 2   ILE 2   2   2   ILE ILE L . n 
D 2 3   VAL 3   3   3   VAL VAL L . n 
D 2 4   MET 4   4   4   MET MET L . n 
D 2 5   THR 5   5   5   THR THR L . n 
D 2 6   GLN 6   6   6   GLN GLN L . n 
D 2 7   SER 7   7   7   SER SER L . n 
D 2 8   PRO 8   8   8   PRO PRO L . n 
D 2 9   ASP 9   9   9   ASP ASP L . n 
D 2 10  SER 10  10  10  SER SER L . n 
D 2 11  LEU 11  11  11  LEU LEU L . n 
D 2 12  ALA 12  12  12  ALA ALA L . n 
D 2 13  VAL 13  13  13  VAL VAL L . n 
D 2 14  SER 14  14  14  SER SER L . n 
D 2 15  LEU 15  15  15  LEU LEU L . n 
D 2 16  GLY 16  16  16  GLY GLY L . n 
D 2 17  GLU 17  17  17  GLU GLU L . n 
D 2 18  ARG 18  18  18  ARG ARG L . n 
D 2 19  ALA 19  19  19  ALA ALA L . n 
D 2 20  THR 20  20  20  THR THR L . n 
D 2 21  ILE 21  21  21  ILE ILE L . n 
D 2 22  ASN 22  22  22  ASN ASN L . n 
D 2 23  CYS 23  23  23  CYS CYS L . n 
D 2 24  LYS 24  24  24  LYS LYS L . n 
D 2 25  SER 25  25  25  SER SER L . n 
D 2 26  SER 26  26  26  SER SER L . n 
D 2 27  GLN 27  27  27  GLN GLN L . n 
D 2 28  SER 28  28  28  SER SER L . n 
D 2 29  VAL 29  29  29  VAL VAL L . n 
D 2 30  LEU 30  30  30  LEU LEU L . n 
D 2 31  TYR 31  31  31  TYR TYR L . n 
D 2 32  SER 32  32  32  SER SER L . n 
D 2 33  SER 33  33  33  SER SER L . n 
D 2 34  ASN 34  34  34  ASN ASN L . n 
D 2 35  GLN 35  35  35  GLN GLN L . n 
D 2 36  MET 36  36  36  MET MET L . n 
D 2 37  ASN 37  37  37  ASN ASN L . n 
D 2 38  TYR 38  38  38  TYR TYR L . n 
D 2 39  LEU 39  39  39  LEU LEU L . n 
D 2 40  ALA 40  40  40  ALA ALA L . n 
D 2 41  TRP 41  41  41  TRP TRP L . n 
D 2 42  TYR 42  42  42  TYR TYR L . n 
D 2 43  GLN 43  43  43  GLN GLN L . n 
D 2 44  GLN 44  44  44  GLN GLN L . n 
D 2 45  LYS 45  45  45  LYS LYS L . n 
D 2 46  PRO 46  46  46  PRO PRO L . n 
D 2 47  GLY 47  47  47  GLY GLY L . n 
D 2 48  GLN 48  48  48  GLN GLN L . n 
D 2 49  PRO 49  49  49  PRO PRO L . n 
D 2 50  PRO 50  50  50  PRO PRO L . n 
D 2 51  LYS 51  51  51  LYS LYS L . n 
D 2 52  LEU 52  52  52  LEU LEU L . n 
D 2 53  LEU 53  53  53  LEU LEU L . n 
D 2 54  ILE 54  54  54  ILE ILE L . n 
D 2 55  TYR 55  55  55  TYR TYR L . n 
D 2 56  TRP 56  56  56  TRP TRP L . n 
D 2 57  ALA 57  57  57  ALA ALA L . n 
D 2 58  SER 58  58  58  SER SER L . n 
D 2 59  THR 59  59  59  THR THR L . n 
D 2 60  ARG 60  60  60  ARG ARG L . n 
D 2 61  GLU 61  61  61  GLU GLU L . n 
D 2 62  SER 62  62  62  SER SER L . n 
D 2 63  GLY 63  63  63  GLY GLY L . n 
D 2 64  VAL 64  64  64  VAL VAL L . n 
D 2 65  PRO 65  65  65  PRO PRO L . n 
D 2 66  ASP 66  66  66  ASP ASP L . n 
D 2 67  ARG 67  67  67  ARG ARG L . n 
D 2 68  PHE 68  68  68  PHE PHE L . n 
D 2 69  SER 69  69  69  SER SER L . n 
D 2 70  GLY 70  70  70  GLY GLY L . n 
D 2 71  SER 71  71  71  SER SER L . n 
D 2 72  GLY 72  72  72  GLY GLY L . n 
D 2 73  SER 73  73  73  SER SER L . n 
D 2 74  GLY 74  74  74  GLY GLY L . n 
D 2 75  THR 75  75  75  THR THR L . n 
D 2 76  ASP 76  76  76  ASP ASP L . n 
D 2 77  PHE 77  77  77  PHE PHE L . n 
D 2 78  THR 78  78  78  THR THR L . n 
D 2 79  LEU 79  79  79  LEU LEU L . n 
D 2 80  THR 80  80  80  THR THR L . n 
D 2 81  ILE 81  81  81  ILE ILE L . n 
D 2 82  SER 82  82  82  SER SER L . n 
D 2 83  SER 83  83  83  SER SER L . n 
D 2 84  LEU 84  84  84  LEU LEU L . n 
D 2 85  GLN 85  85  85  GLN GLN L . n 
D 2 86  ALA 86  86  86  ALA ALA L . n 
D 2 87  GLU 87  87  87  GLU GLU L . n 
D 2 88  ASP 88  88  88  ASP ASP L . n 
D 2 89  VAL 89  89  89  VAL VAL L . n 
D 2 90  ALA 90  90  90  ALA ALA L . n 
D 2 91  VAL 91  91  91  VAL VAL L . n 
D 2 92  TYR 92  92  92  TYR TYR L . n 
D 2 93  TYR 93  93  93  TYR TYR L . n 
D 2 94  CYS 94  94  94  CYS CYS L . n 
D 2 95  LEU 95  95  95  LEU LEU L . n 
D 2 96  GLN 96  96  96  GLN GLN L . n 
D 2 97  TYR 97  97  97  TYR TYR L . n 
D 2 98  LEU 98  98  98  LEU LEU L . n 
D 2 99  SER 99  99  99  SER SER L . n 
D 2 100 SER 100 100 100 SER SER L . n 
D 2 101 TRP 101 101 101 TRP TRP L . n 
D 2 102 THR 102 102 102 THR THR L . n 
D 2 103 PHE 103 103 103 PHE PHE L . n 
D 2 104 GLY 104 104 104 GLY GLY L . n 
D 2 105 GLY 105 105 105 GLY GLY L . n 
D 2 106 GLY 106 106 106 GLY GLY L . n 
D 2 107 THR 107 107 107 THR THR L . n 
D 2 108 LYS 108 108 108 LYS LYS L . n 
D 2 109 LEU 109 109 109 LEU LEU L . n 
D 2 110 GLU 110 110 110 GLU GLU L . n 
D 2 111 ILE 111 111 111 ILE ILE L . n 
D 2 112 LYS 112 112 112 LYS LYS L . n 
D 2 113 ARG 113 113 113 ARG ARG L . n 
D 2 114 THR 114 114 114 THR THR L . n 
D 2 115 VAL 115 115 115 VAL VAL L . n 
D 2 116 ALA 116 116 116 ALA ALA L . n 
D 2 117 ALA 117 117 117 ALA ALA L . n 
D 2 118 PRO 118 118 118 PRO PRO L . n 
D 2 119 SER 119 119 119 SER SER L . n 
D 2 120 VAL 120 120 120 VAL VAL L . n 
D 2 121 PHE 121 121 121 PHE PHE L . n 
D 2 122 ILE 122 122 122 ILE ILE L . n 
D 2 123 PHE 123 123 123 PHE PHE L . n 
D 2 124 PRO 124 124 124 PRO PRO L . n 
D 2 125 PRO 125 125 125 PRO PRO L . n 
D 2 126 SER 126 126 126 SER SER L . n 
D 2 127 ASP 127 127 127 ASP ASP L . n 
D 2 128 GLU 128 128 128 GLU GLU L . n 
D 2 129 GLN 129 129 129 GLN GLN L . n 
D 2 130 LEU 130 130 130 LEU LEU L . n 
D 2 131 LYS 131 131 131 LYS LYS L . n 
D 2 132 SER 132 132 132 SER SER L . n 
D 2 133 GLY 133 133 133 GLY GLY L . n 
D 2 134 THR 134 134 134 THR THR L . n 
D 2 135 ALA 135 135 135 ALA ALA L . n 
D 2 136 SER 136 136 136 SER SER L . n 
D 2 137 VAL 137 137 137 VAL VAL L . n 
D 2 138 VAL 138 138 138 VAL VAL L . n 
D 2 139 CYS 139 139 139 CYS CYS L . n 
D 2 140 LEU 140 140 140 LEU LEU L . n 
D 2 141 LEU 141 141 141 LEU LEU L . n 
D 2 142 ASN 142 142 142 ASN ASN L . n 
D 2 143 ASN 143 143 143 ASN ASN L . n 
D 2 144 PHE 144 144 144 PHE PHE L . n 
D 2 145 TYR 145 145 145 TYR TYR L . n 
D 2 146 PRO 146 146 146 PRO PRO L . n 
D 2 147 ARG 147 147 147 ARG ARG L . n 
D 2 148 GLU 148 148 148 GLU GLU L . n 
D 2 149 ALA 149 149 149 ALA ALA L . n 
D 2 150 LYS 150 150 150 LYS LYS L . n 
D 2 151 VAL 151 151 151 VAL VAL L . n 
D 2 152 GLN 152 152 152 GLN GLN L . n 
D 2 153 TRP 153 153 153 TRP TRP L . n 
D 2 154 LYS 154 154 154 LYS LYS L . n 
D 2 155 VAL 155 155 155 VAL VAL L . n 
D 2 156 ASP 156 156 156 ASP ASP L . n 
D 2 157 ASN 157 157 157 ASN ASN L . n 
D 2 158 ALA 158 158 158 ALA ALA L . n 
D 2 159 LEU 159 159 159 LEU LEU L . n 
D 2 160 GLN 160 160 160 GLN GLN L . n 
D 2 161 SER 161 161 161 SER SER L . n 
D 2 162 GLY 162 162 162 GLY GLY L . n 
D 2 163 ASN 163 163 163 ASN ASN L . n 
D 2 164 SER 164 164 164 SER SER L . n 
D 2 165 GLN 165 165 165 GLN GLN L . n 
D 2 166 GLU 166 166 166 GLU GLU L . n 
D 2 167 SER 167 167 167 SER SER L . n 
D 2 168 VAL 168 168 168 VAL VAL L . n 
D 2 169 THR 169 169 169 THR THR L . n 
D 2 170 GLU 170 170 170 GLU GLU L . n 
D 2 171 GLN 171 171 171 GLN GLN L . n 
D 2 172 ASP 172 172 172 ASP ASP L . n 
D 2 173 SER 173 173 173 SER SER L . n 
D 2 174 LYS 174 174 174 LYS LYS L . n 
D 2 175 ASP 175 175 175 ASP ASP L . n 
D 2 176 SER 176 176 176 SER SER L . n 
D 2 177 THR 177 177 177 THR THR L . n 
D 2 178 TYR 178 178 178 TYR TYR L . n 
D 2 179 SER 179 179 179 SER SER L . n 
D 2 180 LEU 180 180 180 LEU LEU L . n 
D 2 181 SER 181 181 181 SER SER L . n 
D 2 182 SER 182 182 182 SER SER L . n 
D 2 183 THR 183 183 183 THR THR L . n 
D 2 184 LEU 184 184 184 LEU LEU L . n 
D 2 185 THR 185 185 185 THR THR L . n 
D 2 186 LEU 186 186 186 LEU LEU L . n 
D 2 187 SER 187 187 187 SER SER L . n 
D 2 188 LYS 188 188 188 LYS LYS L . n 
D 2 189 ALA 189 189 189 ALA ALA L . n 
D 2 190 ASP 190 190 190 ASP ASP L . n 
D 2 191 TYR 191 191 191 TYR TYR L . n 
D 2 192 GLU 192 192 192 GLU GLU L . n 
D 2 193 LYS 193 193 193 LYS LYS L . n 
D 2 194 HIS 194 194 194 HIS HIS L . n 
D 2 195 LYS 195 195 195 LYS LYS L . n 
D 2 196 LEU 196 196 196 LEU LEU L . n 
D 2 197 TYR 197 197 197 TYR TYR L . n 
D 2 198 ALA 198 198 198 ALA ALA L . n 
D 2 199 CYS 199 199 199 CYS CYS L . n 
D 2 200 GLU 200 200 200 GLU GLU L . n 
D 2 201 VAL 201 201 201 VAL VAL L . n 
D 2 202 THR 202 202 202 THR THR L . n 
D 2 203 HIS 203 203 203 HIS HIS L . n 
D 2 204 GLN 204 204 204 GLN GLN L . n 
D 2 205 GLY 205 205 205 GLY GLY L . n 
D 2 206 LEU 206 206 206 LEU LEU L . n 
D 2 207 SER 207 207 207 SER SER L . n 
D 2 208 SER 208 208 208 SER SER L . n 
D 2 209 PRO 209 209 209 PRO PRO L . n 
D 2 210 VAL 210 210 210 VAL VAL L . n 
D 2 211 THR 211 211 211 THR THR L . n 
D 2 212 LYS 212 212 212 LYS LYS L . n 
D 2 213 SER 213 213 213 SER SER L . n 
D 2 214 PHE 214 214 214 PHE PHE L . n 
D 2 215 ASN 215 215 215 ASN ASN L . n 
D 2 216 ARG 216 216 216 ARG ARG L . n 
D 2 217 GLY 217 217 ?   ?   ?   L . n 
D 2 218 GLU 218 218 ?   ?   ?   L . n 
D 2 219 CYS 219 219 ?   ?   ?   L . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        PEU 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   PEU 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 3 PEU 1  301 321 PEU DRG A . 
F 4 IPA 1  301 301 IPA IPA B . 
G 5 HOH 1  401 21  HOH HOH A . 
G 5 HOH 2  402 22  HOH HOH A . 
G 5 HOH 3  403 1   HOH HOH A . 
G 5 HOH 4  404 7   HOH HOH A . 
G 5 HOH 5  405 20  HOH HOH A . 
G 5 HOH 6  406 4   HOH HOH A . 
G 5 HOH 7  407 18  HOH HOH A . 
G 5 HOH 8  408 8   HOH HOH A . 
G 5 HOH 9  409 41  HOH HOH A . 
G 5 HOH 10 410 2   HOH HOH A . 
G 5 HOH 11 411 6   HOH HOH A . 
G 5 HOH 12 412 3   HOH HOH A . 
G 5 HOH 13 413 27  HOH HOH A . 
G 5 HOH 14 414 26  HOH HOH A . 
G 5 HOH 15 415 28  HOH HOH A . 
G 5 HOH 16 416 16  HOH HOH A . 
G 5 HOH 17 417 149 HOH HOH A . 
G 5 HOH 18 418 25  HOH HOH A . 
G 5 HOH 19 419 24  HOH HOH A . 
G 5 HOH 20 420 9   HOH HOH A . 
G 5 HOH 21 421 23  HOH HOH A . 
G 5 HOH 22 422 19  HOH HOH A . 
G 5 HOH 23 423 137 HOH HOH A . 
G 5 HOH 24 424 147 HOH HOH A . 
G 5 HOH 25 425 17  HOH HOH A . 
G 5 HOH 26 426 14  HOH HOH A . 
H 5 HOH 1  401 54  HOH HOH B . 
H 5 HOH 2  402 47  HOH HOH B . 
H 5 HOH 3  403 13  HOH HOH B . 
H 5 HOH 4  404 5   HOH HOH B . 
H 5 HOH 5  405 50  HOH HOH B . 
H 5 HOH 6  406 31  HOH HOH B . 
H 5 HOH 7  407 38  HOH HOH B . 
H 5 HOH 8  408 32  HOH HOH B . 
H 5 HOH 9  409 56  HOH HOH B . 
H 5 HOH 10 410 43  HOH HOH B . 
H 5 HOH 11 411 46  HOH HOH B . 
H 5 HOH 12 412 58  HOH HOH B . 
H 5 HOH 13 413 42  HOH HOH B . 
H 5 HOH 14 414 61  HOH HOH B . 
H 5 HOH 15 415 29  HOH HOH B . 
H 5 HOH 16 416 37  HOH HOH B . 
H 5 HOH 17 417 48  HOH HOH B . 
H 5 HOH 18 418 40  HOH HOH B . 
H 5 HOH 19 419 12  HOH HOH B . 
H 5 HOH 20 420 55  HOH HOH B . 
H 5 HOH 21 421 53  HOH HOH B . 
H 5 HOH 22 422 52  HOH HOH B . 
H 5 HOH 23 423 35  HOH HOH B . 
H 5 HOH 24 424 33  HOH HOH B . 
H 5 HOH 25 425 45  HOH HOH B . 
H 5 HOH 26 426 57  HOH HOH B . 
H 5 HOH 27 427 15  HOH HOH B . 
H 5 HOH 28 428 51  HOH HOH B . 
H 5 HOH 29 429 49  HOH HOH B . 
H 5 HOH 30 430 162 HOH HOH B . 
H 5 HOH 31 431 60  HOH HOH B . 
H 5 HOH 32 432 44  HOH HOH B . 
H 5 HOH 33 433 11  HOH HOH B . 
H 5 HOH 34 434 59  HOH HOH B . 
H 5 HOH 35 435 10  HOH HOH B . 
I 5 HOH 1  301 158 HOH HOH H . 
I 5 HOH 2  302 99  HOH HOH H . 
I 5 HOH 3  303 63  HOH HOH H . 
I 5 HOH 4  304 70  HOH HOH H . 
I 5 HOH 5  305 175 HOH HOH H . 
I 5 HOH 6  306 170 HOH HOH H . 
I 5 HOH 7  307 94  HOH HOH H . 
I 5 HOH 8  308 83  HOH HOH H . 
I 5 HOH 9  309 88  HOH HOH H . 
I 5 HOH 10 310 39  HOH HOH H . 
I 5 HOH 11 311 152 HOH HOH H . 
I 5 HOH 12 312 110 HOH HOH H . 
I 5 HOH 13 313 169 HOH HOH H . 
I 5 HOH 14 314 171 HOH HOH H . 
I 5 HOH 15 315 79  HOH HOH H . 
I 5 HOH 16 316 30  HOH HOH H . 
I 5 HOH 17 317 176 HOH HOH H . 
I 5 HOH 18 318 168 HOH HOH H . 
I 5 HOH 19 319 85  HOH HOH H . 
I 5 HOH 20 320 76  HOH HOH H . 
I 5 HOH 21 321 84  HOH HOH H . 
I 5 HOH 22 322 87  HOH HOH H . 
I 5 HOH 23 323 67  HOH HOH H . 
I 5 HOH 24 324 97  HOH HOH H . 
I 5 HOH 25 325 114 HOH HOH H . 
I 5 HOH 26 326 73  HOH HOH H . 
I 5 HOH 27 327 68  HOH HOH H . 
I 5 HOH 28 328 86  HOH HOH H . 
I 5 HOH 29 329 34  HOH HOH H . 
I 5 HOH 30 330 82  HOH HOH H . 
I 5 HOH 31 331 109 HOH HOH H . 
I 5 HOH 32 332 172 HOH HOH H . 
I 5 HOH 33 333 111 HOH HOH H . 
I 5 HOH 34 334 155 HOH HOH H . 
I 5 HOH 35 335 93  HOH HOH H . 
I 5 HOH 36 336 72  HOH HOH H . 
I 5 HOH 37 337 65  HOH HOH H . 
I 5 HOH 38 338 104 HOH HOH H . 
I 5 HOH 39 339 153 HOH HOH H . 
I 5 HOH 40 340 108 HOH HOH H . 
I 5 HOH 41 341 105 HOH HOH H . 
I 5 HOH 42 342 64  HOH HOH H . 
I 5 HOH 43 343 156 HOH HOH H . 
I 5 HOH 44 344 166 HOH HOH H . 
I 5 HOH 45 345 122 HOH HOH H . 
I 5 HOH 46 346 174 HOH HOH H . 
I 5 HOH 47 347 112 HOH HOH H . 
I 5 HOH 48 348 81  HOH HOH H . 
I 5 HOH 49 349 157 HOH HOH H . 
I 5 HOH 50 350 36  HOH HOH H . 
I 5 HOH 51 351 154 HOH HOH H . 
I 5 HOH 52 352 101 HOH HOH H . 
I 5 HOH 53 353 113 HOH HOH H . 
I 5 HOH 54 354 160 HOH HOH H . 
I 5 HOH 55 355 102 HOH HOH H . 
I 5 HOH 56 356 165 HOH HOH H . 
I 5 HOH 57 357 106 HOH HOH H . 
I 5 HOH 58 358 96  HOH HOH H . 
I 5 HOH 59 359 78  HOH HOH H . 
I 5 HOH 60 360 173 HOH HOH H . 
I 5 HOH 61 361 119 HOH HOH H . 
I 5 HOH 62 362 74  HOH HOH H . 
I 5 HOH 63 363 62  HOH HOH H . 
I 5 HOH 64 364 118 HOH HOH H . 
I 5 HOH 65 365 66  HOH HOH H . 
I 5 HOH 66 366 117 HOH HOH H . 
I 5 HOH 67 367 107 HOH HOH H . 
I 5 HOH 68 368 125 HOH HOH H . 
J 5 HOH 1  301 145 HOH HOH L . 
J 5 HOH 2  302 164 HOH HOH L . 
J 5 HOH 3  303 180 HOH HOH L . 
J 5 HOH 4  304 146 HOH HOH L . 
J 5 HOH 5  305 139 HOH HOH L . 
J 5 HOH 6  306 135 HOH HOH L . 
J 5 HOH 7  307 77  HOH HOH L . 
J 5 HOH 8  308 159 HOH HOH L . 
J 5 HOH 9  309 126 HOH HOH L . 
J 5 HOH 10 310 136 HOH HOH L . 
J 5 HOH 11 311 100 HOH HOH L . 
J 5 HOH 12 312 131 HOH HOH L . 
J 5 HOH 13 313 69  HOH HOH L . 
J 5 HOH 14 314 151 HOH HOH L . 
J 5 HOH 15 315 89  HOH HOH L . 
J 5 HOH 16 316 128 HOH HOH L . 
J 5 HOH 17 317 129 HOH HOH L . 
J 5 HOH 18 318 71  HOH HOH L . 
J 5 HOH 19 319 133 HOH HOH L . 
J 5 HOH 20 320 141 HOH HOH L . 
J 5 HOH 21 321 90  HOH HOH L . 
J 5 HOH 22 322 179 HOH HOH L . 
J 5 HOH 23 323 116 HOH HOH L . 
J 5 HOH 24 324 138 HOH HOH L . 
J 5 HOH 25 325 130 HOH HOH L . 
J 5 HOH 26 326 178 HOH HOH L . 
J 5 HOH 27 327 161 HOH HOH L . 
J 5 HOH 28 328 80  HOH HOH L . 
J 5 HOH 29 329 92  HOH HOH L . 
J 5 HOH 30 330 148 HOH HOH L . 
J 5 HOH 31 331 98  HOH HOH L . 
J 5 HOH 32 332 143 HOH HOH L . 
J 5 HOH 33 333 120 HOH HOH L . 
J 5 HOH 34 334 103 HOH HOH L . 
J 5 HOH 35 335 115 HOH HOH L . 
J 5 HOH 36 336 132 HOH HOH L . 
J 5 HOH 37 337 167 HOH HOH L . 
J 5 HOH 38 338 134 HOH HOH L . 
J 5 HOH 39 339 124 HOH HOH L . 
J 5 HOH 40 340 144 HOH HOH L . 
J 5 HOH 41 341 121 HOH HOH L . 
J 5 HOH 42 342 177 HOH HOH L . 
J 5 HOH 43 343 127 HOH HOH L . 
J 5 HOH 44 344 91  HOH HOH L . 
J 5 HOH 45 345 163 HOH HOH L . 
J 5 HOH 46 346 95  HOH HOH L . 
J 5 HOH 47 347 142 HOH HOH L . 
J 5 HOH 48 348 140 HOH HOH L . 
J 5 HOH 49 349 150 HOH HOH L . 
J 5 HOH 50 350 75  HOH HOH L . 
J 5 HOH 51 351 123 HOH HOH L . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 N 1 A PEU 301 ? CAA ? E PEU 1 CAA 
2  1 N 1 A PEU 301 ? CCT ? E PEU 1 CCT 
3  1 N 1 A PEU 301 ? CCU ? E PEU 1 CCU 
4  1 N 1 A PEU 301 ? OCV ? E PEU 1 OCV 
5  1 N 1 A PEU 301 ? CCW ? E PEU 1 CCW 
6  1 N 1 A PEU 301 ? CCX ? E PEU 1 CCX 
7  1 N 1 A PEU 301 ? OCY ? E PEU 1 OCY 
8  1 N 1 A PEU 301 ? CCZ ? E PEU 1 CCZ 
9  1 N 1 A PEU 301 ? CDA ? E PEU 1 CDA 
10 1 N 1 A PEU 301 ? ODB ? E PEU 1 ODB 
11 1 N 1 A PEU 301 ? CDC ? E PEU 1 CDC 
12 1 N 1 A PEU 301 ? CDD ? E PEU 1 CDD 
13 1 N 1 A PEU 301 ? ODE ? E PEU 1 ODE 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? REFMAC   ? ? ? 5.8.0411 1 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? SCALA    ? ? ? .        2 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .        3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? MOLREP   ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   111.70 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Z95 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     245.365 
_cell.length_a_esd                 ? 
_cell.length_b                     43.574 
_cell.length_b_esd                 ? 
_cell.length_c                     110.148 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Z95 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Z95 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.88 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.24 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'18% (w/v) PEG-6000, 1% (w/v) PEG-2000-methyl ether, 0.15 M lithium sulfate monohydrate, and 0.1 M citric acid' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'ADSC QUANTUM 315r' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-04-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSRRC BEAMLINE BL13B1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL13B1 
_diffrn_source.pdbx_synchrotron_site       NSRRC 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8Z95 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.26 
_reflns.d_resolution_low                               30.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     50690 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.1 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          14.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.053 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
2.27 2.35  ? ? ? ? ? ? 4989 ? ? ? ? ? ? ? ? ? ? ? 3.7 0.848 ? ? 0.391 0.202 ? 1  1 0.900 0.973 ? 99.2 ? 0.333 ? ? ? ? ? ? ? ? ? 
2.35 2.45  ? ? ? ? ? ? 5078 ? ? ? ? ? ? ? ? ? ? ? 3.7 0.867 ? ? 0.319 0.164 ? 2  1 0.929 0.981 ? 99.7 ? 0.273 ? ? ? ? ? ? ? ? ? 
2.45 2.56  ? ? ? ? ? ? 5074 ? ? ? ? ? ? ? ? ? ? ? 3.8 0.877 ? ? 0.235 0.121 ? 3  1 0.958 0.989 ? 99.9 ? 0.201 ? ? ? ? ? ? ? ? ? 
2.56 2.69  ? ? ? ? ? ? 5036 ? ? ? ? ? ? ? ? ? ? ? 3.7 0.899 ? ? 0.169 0.087 ? 4  1 0.977 0.994 ? 99.8 ? 0.145 ? ? ? ? ? ? ? ? ? 
2.69 2.86  ? ? ? ? ? ? 5021 ? ? ? ? ? ? ? ? ? ? ? 3.7 0.940 ? ? 0.119 0.061 ? 5  1 0.987 0.997 ? 99.7 ? 0.102 ? ? ? ? ? ? ? ? ? 
2.86 3.08  ? ? ? ? ? ? 5075 ? ? ? ? ? ? ? ? ? ? ? 3.7 0.976 ? ? 0.081 0.042 ? 6  1 0.993 0.998 ? 99.3 ? 0.069 ? ? ? ? ? ? ? ? ? 
3.08 3.39  ? ? ? ? ? ? 5068 ? ? ? ? ? ? ? ? ? ? ? 3.6 1.025 ? ? 0.052 0.027 ? 7  1 0.996 0.999 ? 98.9 ? 0.044 ? ? ? ? ? ? ? ? ? 
3.39 3.88  ? ? ? ? ? ? 5064 ? ? ? ? ? ? ? ? ? ? ? 3.5 0.949 ? ? 0.033 0.018 ? 8  1 0.998 1.000 ? 98.9 ? 0.028 ? ? ? ? ? ? ? ? ? 
3.88 4.88  ? ? ? ? ? ? 5076 ? ? ? ? ? ? ? ? ? ? ? 3.5 0.882 ? ? 0.024 0.013 ? 9  1 0.999 1.000 ? 98.2 ? 0.020 ? ? ? ? ? ? ? ? ? 
4.88 30.00 ? ? ? ? ? ? 5209 ? ? ? ? ? ? ? ? ? ? ? 3.3 0.732 ? ? 0.022 0.012 ? 10 1 0.999 1.000 ? 97.9 ? 0.018 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            0.27 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            -0.10 
_refine.aniso_B[2][2]                            -0.09 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            -0.07 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               38.145 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.937 
_refine.correlation_coeff_Fo_to_Fc_free          0.897 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8Z95 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.26 
_refine.ls_d_res_low                             29.81 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     48044 
_refine.ls_number_reflns_R_free                  2611 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.88 
_refine.ls_percent_reflns_R_free                 5.2 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.21214 
_refine.ls_R_factor_R_free                       0.26148 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20944 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      6VL9 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.276 
_refine.pdbx_overall_ESU_R_Free                  0.227 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             6.606 
_refine.overall_SU_ML                            0.164 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.26 
_refine_hist.d_res_low                        29.81 
_refine_hist.number_atoms_solvent             180 
_refine_hist.number_atoms_total               6790 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        6536 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         74 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  6776  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.002  0.016  6224  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.494  1.652  9206  ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.532  1.591  14422 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 8.069  5.000  848   ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 10.565 5.000  20    ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 16.166 10.000 1065  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.064  0.200  1024  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  7702  ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1506  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 3.172  3.816  3410  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 3.172  3.816  3410  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 4.761  6.840  4252  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 4.761  6.840  4253  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 3.426  4.003  3366  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 3.426  4.005  3367  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 5.308  7.233  4955  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 7.160  35.88  7070  ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 7.158  35.82  7055  ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.265 
_refine_ls_shell.d_res_low                        2.323 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             176 
_refine_ls_shell.number_reflns_R_work             3387 
_refine_ls_shell.percent_reflns_obs               96.45 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.257 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.320 
# 
_struct.entry_id                     8Z95 
_struct.title                        'Humanized anti-PEG h6.3 Fab in complex with PEG' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Z95 
_struct_keywords.text            'Anti-PEG, Fab, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 1 ? 
D N N 2 ? 
E N N 3 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 5 ? 
J N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 8Z95 8Z95 ? 1 ? 1 
2 PDB 8Z95 8Z95 ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8Z95 A 1 ? 219 ? 8Z95 1 ? 219 ? 1 219 
2 2 8Z95 B 1 ? 219 ? 8Z95 1 ? 219 ? 1 219 
3 1 8Z95 H 1 ? 219 ? 8Z95 1 ? 219 ? 1 219 
4 2 8Z95 L 1 ? 219 ? 8Z95 1 ? 219 ? 1 219 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2970  ? 
1 MORE         -21   ? 
1 'SSA (A^2)'  19730 ? 
2 'ABSA (A^2)' 4450  ? 
2 MORE         -33   ? 
2 'SSA (A^2)'  20300 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,E,F,G,H 
2 1 C,D,I,J     
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 28  ? TYR A 32  ? THR A 28  TYR A 32  5 ? 5 
HELX_P HELX_P2  AA2 ASN A 62  ? LYS A 65  ? ASN A 62  LYS A 65  5 ? 4 
HELX_P HELX_P3  AA3 THR A 74  ? VAL A 76  ? THR A 74  VAL A 76  5 ? 3 
HELX_P HELX_P4  AA4 LYS A 87  ? THR A 91  ? LYS A 87  THR A 91  5 ? 5 
HELX_P HELX_P5  AA5 SER A 188 ? GLN A 193 ? SER A 188 GLN A 193 1 ? 6 
HELX_P HELX_P6  AA6 LYS A 202 ? ASN A 205 ? LYS A 202 ASN A 205 5 ? 4 
HELX_P HELX_P7  AA7 GLN B 85  ? VAL B 89  ? GLN B 85  VAL B 89  5 ? 5 
HELX_P HELX_P8  AA8 SER B 126 ? GLY B 133 ? SER B 126 GLY B 133 1 ? 8 
HELX_P HELX_P9  AA9 LYS B 188 ? LYS B 193 ? LYS B 188 LYS B 193 1 ? 6 
HELX_P HELX_P10 AB1 THR C 28  ? TYR C 32  ? THR H 28  TYR H 32  5 ? 5 
HELX_P HELX_P11 AB2 THR C 74  ? VAL C 76  ? THR H 74  VAL H 76  5 ? 3 
HELX_P HELX_P12 AB3 LYS C 87  ? THR C 91  ? LYS H 87  THR H 91  5 ? 5 
HELX_P HELX_P13 AB4 SER C 157 ? ALA C 159 ? SER H 157 ALA H 159 5 ? 3 
HELX_P HELX_P14 AB5 SER C 188 ? LEU C 190 ? SER H 188 LEU H 190 5 ? 3 
HELX_P HELX_P15 AB6 LYS C 202 ? ASN C 205 ? LYS H 202 ASN H 205 5 ? 4 
HELX_P HELX_P16 AB7 GLN D 85  ? VAL D 89  ? GLN L 85  VAL L 89  5 ? 5 
HELX_P HELX_P17 AB8 SER D 126 ? SER D 132 ? SER L 126 SER L 132 1 ? 7 
HELX_P HELX_P18 AB9 LYS D 188 ? LYS D 193 ? LYS L 188 LYS L 193 1 ? 6 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 22  SG ? ? ? 1_555 A CYS 96  SG ? ? A CYS 22  A CYS 96  1_555 ? ? ? ? ? ? ? 2.050 ? ? 
disulf2 disulf ? ? A CYS 141 SG ? ? ? 1_555 A CYS 197 SG ? ? A CYS 141 A CYS 197 1_555 ? ? ? ? ? ? ? 2.040 ? ? 
disulf3 disulf ? ? B CYS 23  SG ? ? ? 1_555 B CYS 94  SG ? ? B CYS 23  B CYS 94  1_555 ? ? ? ? ? ? ? 2.216 ? ? 
disulf4 disulf ? ? B CYS 139 SG ? ? ? 1_555 B CYS 199 SG ? ? B CYS 139 B CYS 199 1_555 ? ? ? ? ? ? ? 2.081 ? ? 
disulf5 disulf ? ? C CYS 22  SG ? ? ? 1_555 C CYS 96  SG ? ? H CYS 22  H CYS 96  1_555 ? ? ? ? ? ? ? 2.087 ? ? 
disulf6 disulf ? ? C CYS 141 SG ? ? ? 1_555 C CYS 197 SG ? ? H CYS 141 H CYS 197 1_555 ? ? ? ? ? ? ? 2.042 ? ? 
disulf7 disulf ? ? D CYS 23  SG ? ? ? 1_555 D CYS 94  SG ? ? L CYS 23  L CYS 94  1_555 ? ? ? ? ? ? ? 2.231 ? ? 
disulf8 disulf ? ? D CYS 139 SG ? ? ? 1_555 D CYS 199 SG ? ? L CYS 139 L CYS 199 1_555 ? ? ? ? ? ? ? 2.061 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 22  ? CYS A 96  ? CYS A 22  ? 1_555 CYS A 96  ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 141 ? CYS A 197 ? CYS A 141 ? 1_555 CYS A 197 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 23  ? CYS B 94  ? CYS B 23  ? 1_555 CYS B 94  ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 139 ? CYS B 199 ? CYS B 139 ? 1_555 CYS B 199 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS C 22  ? CYS C 96  ? CYS H 22  ? 1_555 CYS H 96  ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS C 141 ? CYS C 197 ? CYS H 141 ? 1_555 CYS H 197 ? 1_555 SG SG . . . None 'Disulfide bridge' 
7 CYS D 23  ? CYS D 94  ? CYS L 23  ? 1_555 CYS L 94  ? 1_555 SG SG . . . None 'Disulfide bridge' 
8 CYS D 139 ? CYS D 199 ? CYS L 139 ? 1_555 CYS L 199 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 147 A . ? PHE 147 A PRO 148 A ? PRO 148 A 1 -11.77 
2 GLU 149 A . ? GLU 149 A PRO 150 A ? PRO 150 A 1 -7.52  
3 SER 7   B . ? SER 7   B PRO 8   B ? PRO 8   B 1 -6.89  
4 TYR 145 B . ? TYR 145 B PRO 146 B ? PRO 146 B 1 -6.87  
5 PHE 147 C . ? PHE 147 H PRO 148 C ? PRO 148 H 1 -12.31 
6 GLU 149 C . ? GLU 149 H PRO 150 C ? PRO 150 H 1 -2.36  
7 SER 7   D . ? SER 7   L PRO 8   D ? PRO 8   L 1 -6.70  
8 TYR 145 D . ? TYR 145 L PRO 146 D ? PRO 146 L 1 13.67  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
AA7 ? 6 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 4 ? 
AB3 ? 6 ? 
AB4 ? 4 ? 
AB5 ? 4 ? 
AB6 ? 3 ? 
AB7 ? 4 ? 
AB8 ? 6 ? 
AB9 ? 4 ? 
AC1 ? 4 ? 
AC2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
AA7 5 6 ? anti-parallel 
AA8 1 2 ? parallel      
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? parallel      
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB3 4 5 ? anti-parallel 
AB3 5 6 ? anti-parallel 
AB4 1 2 ? anti-parallel 
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB5 1 2 ? anti-parallel 
AB5 2 3 ? anti-parallel 
AB5 3 4 ? anti-parallel 
AB6 1 2 ? anti-parallel 
AB6 2 3 ? anti-parallel 
AB7 1 2 ? anti-parallel 
AB7 2 3 ? anti-parallel 
AB7 3 4 ? anti-parallel 
AB8 1 2 ? parallel      
AB8 2 3 ? anti-parallel 
AB8 3 4 ? anti-parallel 
AB8 4 5 ? anti-parallel 
AB8 5 6 ? anti-parallel 
AB9 1 2 ? parallel      
AB9 2 3 ? anti-parallel 
AB9 3 4 ? anti-parallel 
AC1 1 2 ? anti-parallel 
AC1 2 3 ? anti-parallel 
AC1 3 4 ? anti-parallel 
AC2 1 2 ? anti-parallel 
AC2 2 3 ? anti-parallel 
AC2 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 3   ? GLN A 6   ? GLN A 3   GLN A 6   
AA1 2 VAL A 18  ? SER A 25  ? VAL A 18  SER A 25  
AA1 3 THR A 78  ? ILE A 83  ? THR A 78  ILE A 83  
AA1 4 PHE A 68  ? ASP A 73  ? PHE A 68  ASP A 73  
AA2 1 GLU A 10  ? LYS A 12  ? GLU A 10  LYS A 12  
AA2 2 THR A 108 ? VAL A 112 ? THR A 108 VAL A 112 
AA2 3 ALA A 92  ? ARG A 98  ? ALA A 92  ARG A 98  
AA2 4 MET A 34  ? GLN A 39  ? MET A 34  GLN A 39  
AA2 5 GLU A 46  ? ILE A 51  ? GLU A 46  ILE A 51  
AA2 6 PRO A 58  ? TYR A 60  ? PRO A 58  TYR A 60  
AA3 1 SER A 121 ? LEU A 125 ? SER A 121 LEU A 125 
AA3 2 THR A 136 ? TYR A 146 ? THR A 136 TYR A 146 
AA3 3 TYR A 177 ? PRO A 186 ? TYR A 177 PRO A 186 
AA3 4 VAL A 164 ? THR A 166 ? VAL A 164 THR A 166 
AA4 1 SER A 121 ? LEU A 125 ? SER A 121 LEU A 125 
AA4 2 THR A 136 ? TYR A 146 ? THR A 136 TYR A 146 
AA4 3 TYR A 177 ? PRO A 186 ? TYR A 177 PRO A 186 
AA4 4 VAL A 170 ? LEU A 171 ? VAL A 170 LEU A 171 
AA5 1 THR A 152 ? TRP A 155 ? THR A 152 TRP A 155 
AA5 2 ILE A 196 ? HIS A 201 ? ILE A 196 HIS A 201 
AA5 3 THR A 206 ? ARG A 211 ? THR A 206 ARG A 211 
AA6 1 MET B 4   ? SER B 7   ? MET B 4   SER B 7   
AA6 2 ALA B 19  ? SER B 25  ? ALA B 19  SER B 25  
AA6 3 ASP B 76  ? ILE B 81  ? ASP B 76  ILE B 81  
AA6 4 PHE B 68  ? SER B 73  ? PHE B 68  SER B 73  
AA7 1 SER B 10  ? SER B 14  ? SER B 10  SER B 14  
AA7 2 THR B 107 ? LYS B 112 ? THR B 107 LYS B 112 
AA7 3 ALA B 90  ? GLN B 96  ? ALA B 90  GLN B 96  
AA7 4 LEU B 39  ? GLN B 44  ? LEU B 39  GLN B 44  
AA7 5 LYS B 51  ? TYR B 55  ? LYS B 51  TYR B 55  
AA7 6 THR B 59  ? ARG B 60  ? THR B 59  ARG B 60  
AA8 1 SER B 10  ? SER B 14  ? SER B 10  SER B 14  
AA8 2 THR B 107 ? LYS B 112 ? THR B 107 LYS B 112 
AA8 3 ALA B 90  ? GLN B 96  ? ALA B 90  GLN B 96  
AA8 4 THR B 102 ? PHE B 103 ? THR B 102 PHE B 103 
AA9 1 SER B 119 ? PHE B 123 ? SER B 119 PHE B 123 
AA9 2 THR B 134 ? PHE B 144 ? THR B 134 PHE B 144 
AA9 3 TYR B 178 ? SER B 187 ? TYR B 178 SER B 187 
AA9 4 SER B 164 ? VAL B 168 ? SER B 164 VAL B 168 
AB1 1 ALA B 158 ? LEU B 159 ? ALA B 158 LEU B 159 
AB1 2 LYS B 150 ? VAL B 155 ? LYS B 150 VAL B 155 
AB1 3 LEU B 196 ? THR B 202 ? LEU B 196 THR B 202 
AB1 4 VAL B 210 ? ASN B 215 ? VAL B 210 ASN B 215 
AB2 1 GLN C 3   ? GLN C 6   ? GLN H 3   GLN H 6   
AB2 2 VAL C 18  ? SER C 25  ? VAL H 18  SER H 25  
AB2 3 THR C 78  ? ILE C 83  ? THR H 78  ILE H 83  
AB2 4 PHE C 68  ? ASP C 73  ? PHE H 68  ASP H 73  
AB3 1 GLU C 10  ? LYS C 12  ? GLU H 10  LYS H 12  
AB3 2 THR C 108 ? VAL C 112 ? THR H 108 VAL H 112 
AB3 3 ALA C 92  ? ARG C 98  ? ALA H 92  ARG H 98  
AB3 4 MET C 34  ? GLN C 39  ? MET H 34  GLN H 39  
AB3 5 GLU C 46  ? ILE C 51  ? GLU H 46  ILE H 51  
AB3 6 PRO C 58  ? TYR C 60  ? PRO H 58  TYR H 60  
AB4 1 SER C 121 ? LEU C 125 ? SER H 121 LEU H 125 
AB4 2 THR C 136 ? TYR C 146 ? THR H 136 TYR H 146 
AB4 3 TYR C 177 ? PRO C 186 ? TYR H 177 PRO H 186 
AB4 4 VAL C 164 ? THR C 166 ? VAL H 164 THR H 166 
AB5 1 SER C 121 ? LEU C 125 ? SER H 121 LEU H 125 
AB5 2 THR C 136 ? TYR C 146 ? THR H 136 TYR H 146 
AB5 3 TYR C 177 ? PRO C 186 ? TYR H 177 PRO H 186 
AB5 4 VAL C 170 ? LEU C 171 ? VAL H 170 LEU H 171 
AB6 1 THR C 152 ? TRP C 155 ? THR H 152 TRP H 155 
AB6 2 ILE C 196 ? HIS C 201 ? ILE H 196 HIS H 201 
AB6 3 THR C 206 ? ARG C 211 ? THR H 206 ARG H 211 
AB7 1 MET D 4   ? SER D 7   ? MET L 4   SER L 7   
AB7 2 ALA D 19  ? SER D 25  ? ALA L 19  SER L 25  
AB7 3 ASP D 76  ? ILE D 81  ? ASP L 76  ILE L 81  
AB7 4 PHE D 68  ? SER D 73  ? PHE L 68  SER L 73  
AB8 1 SER D 10  ? VAL D 13  ? SER L 10  VAL L 13  
AB8 2 THR D 107 ? ILE D 111 ? THR L 107 ILE L 111 
AB8 3 ALA D 90  ? GLN D 96  ? ALA L 90  GLN L 96  
AB8 4 LEU D 39  ? GLN D 44  ? LEU L 39  GLN L 44  
AB8 5 LYS D 51  ? TYR D 55  ? LYS L 51  TYR L 55  
AB8 6 THR D 59  ? ARG D 60  ? THR L 59  ARG L 60  
AB9 1 SER D 10  ? VAL D 13  ? SER L 10  VAL L 13  
AB9 2 THR D 107 ? ILE D 111 ? THR L 107 ILE L 111 
AB9 3 ALA D 90  ? GLN D 96  ? ALA L 90  GLN L 96  
AB9 4 THR D 102 ? PHE D 103 ? THR L 102 PHE L 103 
AC1 1 SER D 119 ? PHE D 123 ? SER L 119 PHE L 123 
AC1 2 THR D 134 ? PHE D 144 ? THR L 134 PHE L 144 
AC1 3 TYR D 178 ? SER D 187 ? TYR L 178 SER L 187 
AC1 4 SER D 164 ? VAL D 168 ? SER L 164 VAL L 168 
AC2 1 ALA D 158 ? LEU D 159 ? ALA L 158 LEU L 159 
AC2 2 ALA D 149 ? VAL D 155 ? ALA L 149 VAL L 155 
AC2 3 LEU D 196 ? HIS D 203 ? LEU L 196 HIS L 203 
AC2 4 VAL D 210 ? ASN D 215 ? VAL L 210 ASN L 215 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 5   ? N VAL A 5   O LYS A 23  ? O LYS A 23  
AA1 2 3 N VAL A 20  ? N VAL A 20  O LEU A 81  ? O LEU A 81  
AA1 3 4 O TYR A 80  ? O TYR A 80  N SER A 71  ? N SER A 71  
AA2 1 2 N LYS A 12  ? N LYS A 12  O THR A 111 ? O THR A 111 
AA2 2 3 O VAL A 110 ? O VAL A 110 N ALA A 92  ? N ALA A 92  
AA2 3 4 O TYR A 95  ? O TYR A 95  N VAL A 37  ? N VAL A 37  
AA2 4 5 N TRP A 36  ? N TRP A 36  O MET A 48  ? O MET A 48  
AA2 5 6 N TRP A 50  ? N TRP A 50  O ILE A 59  ? O ILE A 59  
AA3 1 2 N PHE A 123 ? N PHE A 123 O LEU A 142 ? O LEU A 142 
AA3 2 3 N VAL A 143 ? N VAL A 143 O LEU A 179 ? O LEU A 179 
AA3 3 4 O VAL A 182 ? O VAL A 182 N HIS A 165 ? N HIS A 165 
AA4 1 2 N PHE A 123 ? N PHE A 123 O LEU A 142 ? O LEU A 142 
AA4 2 3 N VAL A 143 ? N VAL A 143 O LEU A 179 ? O LEU A 179 
AA4 3 4 O SER A 178 ? O SER A 178 N VAL A 170 ? N VAL A 170 
AA5 1 2 N THR A 152 ? N THR A 152 O ASN A 200 ? O ASN A 200 
AA5 2 3 N VAL A 199 ? N VAL A 199 O VAL A 208 ? O VAL A 208 
AA6 1 2 N SER B 7   ? N SER B 7   O ASN B 22  ? O ASN B 22  
AA6 2 3 N ALA B 19  ? N ALA B 19  O ILE B 81  ? O ILE B 81  
AA6 3 4 O THR B 80  ? O THR B 80  N SER B 69  ? N SER B 69  
AA7 1 2 N LEU B 11  ? N LEU B 11  O GLU B 110 ? O GLU B 110 
AA7 2 3 O LEU B 109 ? O LEU B 109 N ALA B 90  ? N ALA B 90  
AA7 3 4 O VAL B 91  ? O VAL B 91  N GLN B 44  ? N GLN B 44  
AA7 4 5 N TRP B 41  ? N TRP B 41  O LEU B 53  ? O LEU B 53  
AA7 5 6 N TYR B 55  ? N TYR B 55  O THR B 59  ? O THR B 59  
AA8 1 2 N LEU B 11  ? N LEU B 11  O GLU B 110 ? O GLU B 110 
AA8 2 3 O LEU B 109 ? O LEU B 109 N ALA B 90  ? N ALA B 90  
AA8 3 4 N GLN B 96  ? N GLN B 96  O THR B 102 ? O THR B 102 
AA9 1 2 N PHE B 121 ? N PHE B 121 O LEU B 140 ? O LEU B 140 
AA9 2 3 N ALA B 135 ? N ALA B 135 O LEU B 186 ? O LEU B 186 
AA9 3 4 O SER B 181 ? O SER B 181 N SER B 167 ? N SER B 167 
AB1 1 2 O ALA B 158 ? O ALA B 158 N VAL B 155 ? N VAL B 155 
AB1 2 3 N GLN B 152 ? N GLN B 152 O GLU B 200 ? O GLU B 200 
AB1 3 4 N TYR B 197 ? N TYR B 197 O PHE B 214 ? O PHE B 214 
AB2 1 2 N VAL C 5   ? N VAL H 5   O LYS C 23  ? O LYS H 23  
AB2 2 3 N VAL C 20  ? N VAL H 20  O LEU C 81  ? O LEU H 81  
AB2 3 4 O TYR C 80  ? O TYR H 80  N SER C 71  ? N SER H 71  
AB3 1 2 N LYS C 12  ? N LYS H 12  O THR C 111 ? O THR H 111 
AB3 2 3 O VAL C 110 ? O VAL H 110 N ALA C 92  ? N ALA H 92  
AB3 3 4 O VAL C 93  ? O VAL H 93  N GLN C 39  ? N GLN H 39  
AB3 4 5 N TRP C 36  ? N TRP H 36  O MET C 48  ? O MET H 48  
AB3 5 6 N TRP C 50  ? N TRP H 50  O ILE C 59  ? O ILE H 59  
AB4 1 2 N PHE C 123 ? N PHE H 123 O LEU C 142 ? O LEU H 142 
AB4 2 3 N VAL C 143 ? N VAL H 143 O LEU C 179 ? O LEU H 179 
AB4 3 4 O VAL C 182 ? O VAL H 182 N HIS C 165 ? N HIS H 165 
AB5 1 2 N PHE C 123 ? N PHE H 123 O LEU C 142 ? O LEU H 142 
AB5 2 3 N VAL C 143 ? N VAL H 143 O LEU C 179 ? O LEU H 179 
AB5 3 4 O SER C 178 ? O SER H 178 N VAL C 170 ? N VAL H 170 
AB6 1 2 N THR C 152 ? N THR H 152 O ASN C 200 ? O ASN H 200 
AB6 2 3 N VAL C 199 ? N VAL H 199 O VAL C 208 ? O VAL H 208 
AB7 1 2 N SER D 7   ? N SER L 7   O ASN D 22  ? O ASN L 22  
AB7 2 3 N ILE D 21  ? N ILE L 21  O LEU D 79  ? O LEU L 79  
AB7 3 4 O THR D 80  ? O THR L 80  N SER D 69  ? N SER L 69  
AB8 1 2 N LEU D 11  ? N LEU L 11  O GLU D 110 ? O GLU L 110 
AB8 2 3 O LEU D 109 ? O LEU L 109 N ALA D 90  ? N ALA L 90  
AB8 3 4 O VAL D 91  ? O VAL L 91  N GLN D 44  ? N GLN L 44  
AB8 4 5 N GLN D 43  ? N GLN L 43  O LYS D 51  ? O LYS L 51  
AB8 5 6 N TYR D 55  ? N TYR L 55  O THR D 59  ? O THR L 59  
AB9 1 2 N LEU D 11  ? N LEU L 11  O GLU D 110 ? O GLU L 110 
AB9 2 3 O LEU D 109 ? O LEU L 109 N ALA D 90  ? N ALA L 90  
AB9 3 4 N GLN D 96  ? N GLN L 96  O THR D 102 ? O THR L 102 
AC1 1 2 N PHE D 123 ? N PHE L 123 O VAL D 138 ? O VAL L 138 
AC1 2 3 N PHE D 144 ? N PHE L 144 O TYR D 178 ? O TYR L 178 
AC1 3 4 O THR D 183 ? O THR L 183 N GLN D 165 ? N GLN L 165 
AC2 1 2 O ALA D 158 ? O ALA L 158 N VAL D 155 ? N VAL L 155 
AC2 2 3 N GLN D 152 ? N GLN L 152 O GLU D 200 ? O GLU L 200 
AC2 3 4 N VAL D 201 ? N VAL L 201 O VAL D 210 ? O VAL L 210 
# 
_pdbx_entry_details.entry_id                   8Z95 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             H 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              98 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             H 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              98 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH2 
_pdbx_validate_rmsd_angle.auth_asym_id_3             H 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              98 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                117.04 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            -3.26 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 TRP A 100 ? ? 72.86   102.29  
2  1 ALA B 57  ? ? 75.27   -34.89  
3  1 SER B 58  ? ? -142.54 -0.49   
4  1 ALA B 90  ? ? 174.56  175.78  
5  1 SER B 100 ? ? 56.87   -171.30 
6  1 ASN B 163 ? ? -140.77 15.66   
7  1 LYS B 195 ? ? -128.71 -64.65  
8  1 ARG B 216 ? ? -51.20  88.85   
9  1 TRP H 100 ? ? 75.69   101.39  
10 1 LYS H 130 ? ? -43.14  96.56   
11 1 ASP H 145 ? ? 61.66   66.65   
12 1 THR H 192 ? ? -97.56  -74.65  
13 1 ALA L 57  ? ? 76.77   -34.95  
14 1 ALA L 90  ? ? 179.56  175.39  
15 1 SER L 100 ? ? 64.65   -161.05 
16 1 PRO L 146 ? ? -106.70 -163.85 
17 1 ASN L 157 ? ? 81.06   0.00    
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 98 ? ? 0.108 'SIDE CHAIN' 
2 1 ARG H 98 ? ? 0.076 'SIDE CHAIN' 
3 1 ARG L 18 ? ? 0.108 'SIDE CHAIN' 
4 1 ARG L 60 ? ? 0.080 'SIDE CHAIN' 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      H 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       368 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.19 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A LYS 130 ? A LYS 130 
2  1 Y 1 A SER 131 ? A SER 131 
3  1 Y 1 A THR 132 ? A THR 132 
4  1 Y 1 A SER 133 ? A SER 133 
5  1 Y 1 A GLY 134 ? A GLY 134 
6  1 Y 1 A LYS 215 ? A LYS 215 
7  1 Y 1 A SER 216 ? A SER 216 
8  1 Y 1 A CYS 217 ? A CYS 217 
9  1 Y 1 A ASP 218 ? A ASP 218 
10 1 Y 1 A LYS 219 ? A LYS 219 
11 1 Y 1 B GLU 218 ? B GLU 218 
12 1 Y 1 B CYS 219 ? B CYS 219 
13 1 Y 1 H THR 132 ? C THR 132 
14 1 Y 1 H SER 133 ? C SER 133 
15 1 Y 1 H GLY 134 ? C GLY 134 
16 1 Y 1 H SER 216 ? C SER 216 
17 1 Y 1 H CYS 217 ? C CYS 217 
18 1 Y 1 H ASP 218 ? C ASP 218 
19 1 Y 1 H LYS 219 ? C LYS 219 
20 1 Y 1 L GLY 217 ? D GLY 217 
21 1 Y 1 L GLU 218 ? D GLU 218 
22 1 Y 1 L CYS 219 ? D CYS 219 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
IPA C1   C N N 183 
IPA C2   C N N 184 
IPA C3   C N N 185 
IPA O2   O N N 186 
IPA H11  H N N 187 
IPA H12  H N N 188 
IPA H13  H N N 189 
IPA H2   H N N 190 
IPA H31  H N N 191 
IPA H32  H N N 192 
IPA H33  H N N 193 
IPA HO2  H N N 194 
LEU N    N N N 195 
LEU CA   C N S 196 
LEU C    C N N 197 
LEU O    O N N 198 
LEU CB   C N N 199 
LEU CG   C N N 200 
LEU CD1  C N N 201 
LEU CD2  C N N 202 
LEU OXT  O N N 203 
LEU H    H N N 204 
LEU H2   H N N 205 
LEU HA   H N N 206 
LEU HB2  H N N 207 
LEU HB3  H N N 208 
LEU HG   H N N 209 
LEU HD11 H N N 210 
LEU HD12 H N N 211 
LEU HD13 H N N 212 
LEU HD21 H N N 213 
LEU HD22 H N N 214 
LEU HD23 H N N 215 
LEU HXT  H N N 216 
LYS N    N N N 217 
LYS CA   C N S 218 
LYS C    C N N 219 
LYS O    O N N 220 
LYS CB   C N N 221 
LYS CG   C N N 222 
LYS CD   C N N 223 
LYS CE   C N N 224 
LYS NZ   N N N 225 
LYS OXT  O N N 226 
LYS H    H N N 227 
LYS H2   H N N 228 
LYS HA   H N N 229 
LYS HB2  H N N 230 
LYS HB3  H N N 231 
LYS HG2  H N N 232 
LYS HG3  H N N 233 
LYS HD2  H N N 234 
LYS HD3  H N N 235 
LYS HE2  H N N 236 
LYS HE3  H N N 237 
LYS HZ1  H N N 238 
LYS HZ2  H N N 239 
LYS HZ3  H N N 240 
LYS HXT  H N N 241 
MET N    N N N 242 
MET CA   C N S 243 
MET C    C N N 244 
MET O    O N N 245 
MET CB   C N N 246 
MET CG   C N N 247 
MET SD   S N N 248 
MET CE   C N N 249 
MET OXT  O N N 250 
MET H    H N N 251 
MET H2   H N N 252 
MET HA   H N N 253 
MET HB2  H N N 254 
MET HB3  H N N 255 
MET HG2  H N N 256 
MET HG3  H N N 257 
MET HE1  H N N 258 
MET HE2  H N N 259 
MET HE3  H N N 260 
MET HXT  H N N 261 
PEU CAA  C N N 262 
PEU OAB  O N N 263 
PEU CAC  C N N 264 
PEU CAD  C N N 265 
PEU OAE  O N N 266 
PEU CAF  C N N 267 
PEU CAG  C N N 268 
PEU OAH  O N N 269 
PEU CAI  C N N 270 
PEU CAJ  C N N 271 
PEU OAK  O N N 272 
PEU CAL  C N N 273 
PEU CAM  C N N 274 
PEU OAN  O N N 275 
PEU CAO  C N N 276 
PEU CAP  C N N 277 
PEU OAQ  O N N 278 
PEU CAR  C N N 279 
PEU CAS  C N N 280 
PEU OAT  O N N 281 
PEU CAU  C N N 282 
PEU CAV  C N N 283 
PEU OAW  O N N 284 
PEU CAX  C N N 285 
PEU CAY  C N N 286 
PEU OAZ  O N N 287 
PEU CBA  C N N 288 
PEU CBB  C N N 289 
PEU OBC  O N N 290 
PEU CCG  C N N 291 
PEU CCF  C N N 292 
PEU OCE  O N N 293 
PEU CCD  C N N 294 
PEU CCC  C N N 295 
PEU OCB  O N N 296 
PEU CCA  C N N 297 
PEU CBZ  C N N 298 
PEU OBY  O N N 299 
PEU CBX  C N N 300 
PEU CBW  C N N 301 
PEU OBV  O N N 302 
PEU CBU  C N N 303 
PEU CBT  C N N 304 
PEU OBS  O N N 305 
PEU CBR  C N N 306 
PEU CBQ  C N N 307 
PEU OBP  O N N 308 
PEU CBO  C N N 309 
PEU CBN  C N N 310 
PEU OBM  O N N 311 
PEU CBL  C N N 312 
PEU CBK  C N N 313 
PEU OBJ  O N N 314 
PEU CBI  C N N 315 
PEU CBH  C N N 316 
PEU OBG  O N N 317 
PEU CBF  C N N 318 
PEU CBE  C N N 319 
PEU OBD  O N N 320 
PEU CCH  C N N 321 
PEU CCI  C N N 322 
PEU OCJ  O N N 323 
PEU CCK  C N N 324 
PEU CCL  C N N 325 
PEU OCM  O N N 326 
PEU CCN  C N N 327 
PEU CCO  C N N 328 
PEU OCP  O N N 329 
PEU CCQ  C N N 330 
PEU CCR  C N N 331 
PEU OCS  O N N 332 
PEU CCT  C N N 333 
PEU CCU  C N N 334 
PEU OCV  O N N 335 
PEU CCW  C N N 336 
PEU CCX  C N N 337 
PEU OCY  O N N 338 
PEU CCZ  C N N 339 
PEU CDA  C N N 340 
PEU ODB  O N N 341 
PEU CDC  C N N 342 
PEU CDD  C N N 343 
PEU ODE  O N N 344 
PEU HAA1 H N N 345 
PEU HAA2 H N N 346 
PEU HAA3 H N N 347 
PEU HAC1 H N N 348 
PEU HAC2 H N N 349 
PEU HAD1 H N N 350 
PEU HAD2 H N N 351 
PEU HAF1 H N N 352 
PEU HAF2 H N N 353 
PEU HAG1 H N N 354 
PEU HAG2 H N N 355 
PEU HAI1 H N N 356 
PEU HAI2 H N N 357 
PEU HAJ1 H N N 358 
PEU HAJ2 H N N 359 
PEU HAL1 H N N 360 
PEU HAL2 H N N 361 
PEU HAM1 H N N 362 
PEU HAM2 H N N 363 
PEU HAO1 H N N 364 
PEU HAO2 H N N 365 
PEU HAP1 H N N 366 
PEU HAP2 H N N 367 
PEU HAR1 H N N 368 
PEU HAR2 H N N 369 
PEU HAS1 H N N 370 
PEU HAS2 H N N 371 
PEU HAU1 H N N 372 
PEU HAU2 H N N 373 
PEU HAV1 H N N 374 
PEU HAV2 H N N 375 
PEU HAX1 H N N 376 
PEU HAX2 H N N 377 
PEU HAY1 H N N 378 
PEU HAY2 H N N 379 
PEU HBA1 H N N 380 
PEU HBA2 H N N 381 
PEU HBB1 H N N 382 
PEU HBB2 H N N 383 
PEU HCG1 H N N 384 
PEU HCG2 H N N 385 
PEU HCF1 H N N 386 
PEU HCF2 H N N 387 
PEU HCD1 H N N 388 
PEU HCD2 H N N 389 
PEU HCC1 H N N 390 
PEU HCC2 H N N 391 
PEU HCA1 H N N 392 
PEU HCA2 H N N 393 
PEU HBZ1 H N N 394 
PEU HBZ2 H N N 395 
PEU HBX1 H N N 396 
PEU HBX2 H N N 397 
PEU HBW1 H N N 398 
PEU HBW2 H N N 399 
PEU HBU1 H N N 400 
PEU HBU2 H N N 401 
PEU HBT1 H N N 402 
PEU HBT2 H N N 403 
PEU HBR1 H N N 404 
PEU HBR2 H N N 405 
PEU HBQ1 H N N 406 
PEU HBQ2 H N N 407 
PEU HBO1 H N N 408 
PEU HBO2 H N N 409 
PEU HBN1 H N N 410 
PEU HBN2 H N N 411 
PEU HBL1 H N N 412 
PEU HBL2 H N N 413 
PEU HBK1 H N N 414 
PEU HBK2 H N N 415 
PEU HBI1 H N N 416 
PEU HBI2 H N N 417 
PEU HBH1 H N N 418 
PEU HBH2 H N N 419 
PEU HBF1 H N N 420 
PEU HBF2 H N N 421 
PEU HBE1 H N N 422 
PEU HBE2 H N N 423 
PEU HCH1 H N N 424 
PEU HCH2 H N N 425 
PEU HCI1 H N N 426 
PEU HCI2 H N N 427 
PEU HCK1 H N N 428 
PEU HCK2 H N N 429 
PEU HCL1 H N N 430 
PEU HCL2 H N N 431 
PEU HCN1 H N N 432 
PEU HCN2 H N N 433 
PEU HCO1 H N N 434 
PEU HCO2 H N N 435 
PEU HCQ1 H N N 436 
PEU HCQ2 H N N 437 
PEU HCR1 H N N 438 
PEU HCR2 H N N 439 
PEU HCT1 H N N 440 
PEU HCT2 H N N 441 
PEU HCU1 H N N 442 
PEU HCU2 H N N 443 
PEU HCW1 H N N 444 
PEU HCW2 H N N 445 
PEU HCX1 H N N 446 
PEU HCX2 H N N 447 
PEU HCZ1 H N N 448 
PEU HCZ2 H N N 449 
PEU HDA1 H N N 450 
PEU HDA2 H N N 451 
PEU HDC1 H N N 452 
PEU HDC2 H N N 453 
PEU HDD1 H N N 454 
PEU HDD2 H N N 455 
PEU HDE  H N N 456 
PHE N    N N N 457 
PHE CA   C N S 458 
PHE C    C N N 459 
PHE O    O N N 460 
PHE CB   C N N 461 
PHE CG   C Y N 462 
PHE CD1  C Y N 463 
PHE CD2  C Y N 464 
PHE CE1  C Y N 465 
PHE CE2  C Y N 466 
PHE CZ   C Y N 467 
PHE OXT  O N N 468 
PHE H    H N N 469 
PHE H2   H N N 470 
PHE HA   H N N 471 
PHE HB2  H N N 472 
PHE HB3  H N N 473 
PHE HD1  H N N 474 
PHE HD2  H N N 475 
PHE HE1  H N N 476 
PHE HE2  H N N 477 
PHE HZ   H N N 478 
PHE HXT  H N N 479 
PRO N    N N N 480 
PRO CA   C N S 481 
PRO C    C N N 482 
PRO O    O N N 483 
PRO CB   C N N 484 
PRO CG   C N N 485 
PRO CD   C N N 486 
PRO OXT  O N N 487 
PRO H    H N N 488 
PRO HA   H N N 489 
PRO HB2  H N N 490 
PRO HB3  H N N 491 
PRO HG2  H N N 492 
PRO HG3  H N N 493 
PRO HD2  H N N 494 
PRO HD3  H N N 495 
PRO HXT  H N N 496 
SER N    N N N 497 
SER CA   C N S 498 
SER C    C N N 499 
SER O    O N N 500 
SER CB   C N N 501 
SER OG   O N N 502 
SER OXT  O N N 503 
SER H    H N N 504 
SER H2   H N N 505 
SER HA   H N N 506 
SER HB2  H N N 507 
SER HB3  H N N 508 
SER HG   H N N 509 
SER HXT  H N N 510 
THR N    N N N 511 
THR CA   C N S 512 
THR C    C N N 513 
THR O    O N N 514 
THR CB   C N R 515 
THR OG1  O N N 516 
THR CG2  C N N 517 
THR OXT  O N N 518 
THR H    H N N 519 
THR H2   H N N 520 
THR HA   H N N 521 
THR HB   H N N 522 
THR HG1  H N N 523 
THR HG21 H N N 524 
THR HG22 H N N 525 
THR HG23 H N N 526 
THR HXT  H N N 527 
TRP N    N N N 528 
TRP CA   C N S 529 
TRP C    C N N 530 
TRP O    O N N 531 
TRP CB   C N N 532 
TRP CG   C Y N 533 
TRP CD1  C Y N 534 
TRP CD2  C Y N 535 
TRP NE1  N Y N 536 
TRP CE2  C Y N 537 
TRP CE3  C Y N 538 
TRP CZ2  C Y N 539 
TRP CZ3  C Y N 540 
TRP CH2  C Y N 541 
TRP OXT  O N N 542 
TRP H    H N N 543 
TRP H2   H N N 544 
TRP HA   H N N 545 
TRP HB2  H N N 546 
TRP HB3  H N N 547 
TRP HD1  H N N 548 
TRP HE1  H N N 549 
TRP HE3  H N N 550 
TRP HZ2  H N N 551 
TRP HZ3  H N N 552 
TRP HH2  H N N 553 
TRP HXT  H N N 554 
TYR N    N N N 555 
TYR CA   C N S 556 
TYR C    C N N 557 
TYR O    O N N 558 
TYR CB   C N N 559 
TYR CG   C Y N 560 
TYR CD1  C Y N 561 
TYR CD2  C Y N 562 
TYR CE1  C Y N 563 
TYR CE2  C Y N 564 
TYR CZ   C Y N 565 
TYR OH   O N N 566 
TYR OXT  O N N 567 
TYR H    H N N 568 
TYR H2   H N N 569 
TYR HA   H N N 570 
TYR HB2  H N N 571 
TYR HB3  H N N 572 
TYR HD1  H N N 573 
TYR HD2  H N N 574 
TYR HE1  H N N 575 
TYR HE2  H N N 576 
TYR HH   H N N 577 
TYR HXT  H N N 578 
VAL N    N N N 579 
VAL CA   C N S 580 
VAL C    C N N 581 
VAL O    O N N 582 
VAL CB   C N N 583 
VAL CG1  C N N 584 
VAL CG2  C N N 585 
VAL OXT  O N N 586 
VAL H    H N N 587 
VAL H2   H N N 588 
VAL HA   H N N 589 
VAL HB   H N N 590 
VAL HG11 H N N 591 
VAL HG12 H N N 592 
VAL HG13 H N N 593 
VAL HG21 H N N 594 
VAL HG22 H N N 595 
VAL HG23 H N N 596 
VAL HXT  H N N 597 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
IPA C1  C2   sing N N 173 
IPA C1  H11  sing N N 174 
IPA C1  H12  sing N N 175 
IPA C1  H13  sing N N 176 
IPA C2  C3   sing N N 177 
IPA C2  O2   sing N N 178 
IPA C2  H2   sing N N 179 
IPA C3  H31  sing N N 180 
IPA C3  H32  sing N N 181 
IPA C3  H33  sing N N 182 
IPA O2  HO2  sing N N 183 
LEU N   CA   sing N N 184 
LEU N   H    sing N N 185 
LEU N   H2   sing N N 186 
LEU CA  C    sing N N 187 
LEU CA  CB   sing N N 188 
LEU CA  HA   sing N N 189 
LEU C   O    doub N N 190 
LEU C   OXT  sing N N 191 
LEU CB  CG   sing N N 192 
LEU CB  HB2  sing N N 193 
LEU CB  HB3  sing N N 194 
LEU CG  CD1  sing N N 195 
LEU CG  CD2  sing N N 196 
LEU CG  HG   sing N N 197 
LEU CD1 HD11 sing N N 198 
LEU CD1 HD12 sing N N 199 
LEU CD1 HD13 sing N N 200 
LEU CD2 HD21 sing N N 201 
LEU CD2 HD22 sing N N 202 
LEU CD2 HD23 sing N N 203 
LEU OXT HXT  sing N N 204 
LYS N   CA   sing N N 205 
LYS N   H    sing N N 206 
LYS N   H2   sing N N 207 
LYS CA  C    sing N N 208 
LYS CA  CB   sing N N 209 
LYS CA  HA   sing N N 210 
LYS C   O    doub N N 211 
LYS C   OXT  sing N N 212 
LYS CB  CG   sing N N 213 
LYS CB  HB2  sing N N 214 
LYS CB  HB3  sing N N 215 
LYS CG  CD   sing N N 216 
LYS CG  HG2  sing N N 217 
LYS CG  HG3  sing N N 218 
LYS CD  CE   sing N N 219 
LYS CD  HD2  sing N N 220 
LYS CD  HD3  sing N N 221 
LYS CE  NZ   sing N N 222 
LYS CE  HE2  sing N N 223 
LYS CE  HE3  sing N N 224 
LYS NZ  HZ1  sing N N 225 
LYS NZ  HZ2  sing N N 226 
LYS NZ  HZ3  sing N N 227 
LYS OXT HXT  sing N N 228 
MET N   CA   sing N N 229 
MET N   H    sing N N 230 
MET N   H2   sing N N 231 
MET CA  C    sing N N 232 
MET CA  CB   sing N N 233 
MET CA  HA   sing N N 234 
MET C   O    doub N N 235 
MET C   OXT  sing N N 236 
MET CB  CG   sing N N 237 
MET CB  HB2  sing N N 238 
MET CB  HB3  sing N N 239 
MET CG  SD   sing N N 240 
MET CG  HG2  sing N N 241 
MET CG  HG3  sing N N 242 
MET SD  CE   sing N N 243 
MET CE  HE1  sing N N 244 
MET CE  HE2  sing N N 245 
MET CE  HE3  sing N N 246 
MET OXT HXT  sing N N 247 
PEU CAA OAB  sing N N 248 
PEU CAA HAA1 sing N N 249 
PEU CAA HAA2 sing N N 250 
PEU CAA HAA3 sing N N 251 
PEU OAB CAC  sing N N 252 
PEU CAC CAD  sing N N 253 
PEU CAC HAC1 sing N N 254 
PEU CAC HAC2 sing N N 255 
PEU CAD OAE  sing N N 256 
PEU CAD HAD1 sing N N 257 
PEU CAD HAD2 sing N N 258 
PEU OAE CAF  sing N N 259 
PEU CAF CAG  sing N N 260 
PEU CAF HAF1 sing N N 261 
PEU CAF HAF2 sing N N 262 
PEU CAG OAH  sing N N 263 
PEU CAG HAG1 sing N N 264 
PEU CAG HAG2 sing N N 265 
PEU OAH CAI  sing N N 266 
PEU CAI CAJ  sing N N 267 
PEU CAI HAI1 sing N N 268 
PEU CAI HAI2 sing N N 269 
PEU CAJ OAK  sing N N 270 
PEU CAJ HAJ1 sing N N 271 
PEU CAJ HAJ2 sing N N 272 
PEU OAK CAL  sing N N 273 
PEU CAL CAM  sing N N 274 
PEU CAL HAL1 sing N N 275 
PEU CAL HAL2 sing N N 276 
PEU CAM OAN  sing N N 277 
PEU CAM HAM1 sing N N 278 
PEU CAM HAM2 sing N N 279 
PEU OAN CAO  sing N N 280 
PEU CAO CAP  sing N N 281 
PEU CAO HAO1 sing N N 282 
PEU CAO HAO2 sing N N 283 
PEU CAP OAQ  sing N N 284 
PEU CAP HAP1 sing N N 285 
PEU CAP HAP2 sing N N 286 
PEU OAQ CAR  sing N N 287 
PEU CAR CAS  sing N N 288 
PEU CAR HAR1 sing N N 289 
PEU CAR HAR2 sing N N 290 
PEU CAS OAT  sing N N 291 
PEU CAS HAS1 sing N N 292 
PEU CAS HAS2 sing N N 293 
PEU OAT CAU  sing N N 294 
PEU CAU CAV  sing N N 295 
PEU CAU HAU1 sing N N 296 
PEU CAU HAU2 sing N N 297 
PEU CAV OAW  sing N N 298 
PEU CAV HAV1 sing N N 299 
PEU CAV HAV2 sing N N 300 
PEU OAW CAX  sing N N 301 
PEU CAX CAY  sing N N 302 
PEU CAX HAX1 sing N N 303 
PEU CAX HAX2 sing N N 304 
PEU CAY OAZ  sing N N 305 
PEU CAY HAY1 sing N N 306 
PEU CAY HAY2 sing N N 307 
PEU OAZ CBA  sing N N 308 
PEU CBA CBB  sing N N 309 
PEU CBA HBA1 sing N N 310 
PEU CBA HBA2 sing N N 311 
PEU CBB OBC  sing N N 312 
PEU CBB HBB1 sing N N 313 
PEU CBB HBB2 sing N N 314 
PEU OBC CCG  sing N N 315 
PEU CCG CCF  sing N N 316 
PEU CCG HCG1 sing N N 317 
PEU CCG HCG2 sing N N 318 
PEU CCF OCE  sing N N 319 
PEU CCF HCF1 sing N N 320 
PEU CCF HCF2 sing N N 321 
PEU OCE CCD  sing N N 322 
PEU CCD CCC  sing N N 323 
PEU CCD HCD1 sing N N 324 
PEU CCD HCD2 sing N N 325 
PEU CCC OCB  sing N N 326 
PEU CCC HCC1 sing N N 327 
PEU CCC HCC2 sing N N 328 
PEU OCB CCA  sing N N 329 
PEU CCA CBZ  sing N N 330 
PEU CCA HCA1 sing N N 331 
PEU CCA HCA2 sing N N 332 
PEU CBZ OBY  sing N N 333 
PEU CBZ HBZ1 sing N N 334 
PEU CBZ HBZ2 sing N N 335 
PEU OBY CBX  sing N N 336 
PEU CBX CBW  sing N N 337 
PEU CBX HBX1 sing N N 338 
PEU CBX HBX2 sing N N 339 
PEU CBW OBV  sing N N 340 
PEU CBW HBW1 sing N N 341 
PEU CBW HBW2 sing N N 342 
PEU OBV CBU  sing N N 343 
PEU CBU CBT  sing N N 344 
PEU CBU HBU1 sing N N 345 
PEU CBU HBU2 sing N N 346 
PEU CBT OBS  sing N N 347 
PEU CBT HBT1 sing N N 348 
PEU CBT HBT2 sing N N 349 
PEU OBS CBR  sing N N 350 
PEU CBR CBQ  sing N N 351 
PEU CBR HBR1 sing N N 352 
PEU CBR HBR2 sing N N 353 
PEU CBQ OBP  sing N N 354 
PEU CBQ HBQ1 sing N N 355 
PEU CBQ HBQ2 sing N N 356 
PEU OBP CBO  sing N N 357 
PEU CBO CBN  sing N N 358 
PEU CBO HBO1 sing N N 359 
PEU CBO HBO2 sing N N 360 
PEU CBN OBM  sing N N 361 
PEU CBN HBN1 sing N N 362 
PEU CBN HBN2 sing N N 363 
PEU OBM CBL  sing N N 364 
PEU CBL CBK  sing N N 365 
PEU CBL HBL1 sing N N 366 
PEU CBL HBL2 sing N N 367 
PEU CBK OBJ  sing N N 368 
PEU CBK HBK1 sing N N 369 
PEU CBK HBK2 sing N N 370 
PEU OBJ CBI  sing N N 371 
PEU CBI CBH  sing N N 372 
PEU CBI HBI1 sing N N 373 
PEU CBI HBI2 sing N N 374 
PEU CBH OBG  sing N N 375 
PEU CBH HBH1 sing N N 376 
PEU CBH HBH2 sing N N 377 
PEU OBG CBF  sing N N 378 
PEU CBF CBE  sing N N 379 
PEU CBF HBF1 sing N N 380 
PEU CBF HBF2 sing N N 381 
PEU CBE OBD  sing N N 382 
PEU CBE HBE1 sing N N 383 
PEU CBE HBE2 sing N N 384 
PEU OBD CCH  sing N N 385 
PEU CCH CCI  sing N N 386 
PEU CCH HCH1 sing N N 387 
PEU CCH HCH2 sing N N 388 
PEU CCI OCJ  sing N N 389 
PEU CCI HCI1 sing N N 390 
PEU CCI HCI2 sing N N 391 
PEU OCJ CCK  sing N N 392 
PEU CCK CCL  sing N N 393 
PEU CCK HCK1 sing N N 394 
PEU CCK HCK2 sing N N 395 
PEU CCL OCM  sing N N 396 
PEU CCL HCL1 sing N N 397 
PEU CCL HCL2 sing N N 398 
PEU OCM CCN  sing N N 399 
PEU CCN CCO  sing N N 400 
PEU CCN HCN1 sing N N 401 
PEU CCN HCN2 sing N N 402 
PEU CCO OCP  sing N N 403 
PEU CCO HCO1 sing N N 404 
PEU CCO HCO2 sing N N 405 
PEU OCP CCQ  sing N N 406 
PEU CCQ CCR  sing N N 407 
PEU CCQ HCQ1 sing N N 408 
PEU CCQ HCQ2 sing N N 409 
PEU CCR OCS  sing N N 410 
PEU CCR HCR1 sing N N 411 
PEU CCR HCR2 sing N N 412 
PEU OCS CCT  sing N N 413 
PEU CCT CCU  sing N N 414 
PEU CCT HCT1 sing N N 415 
PEU CCT HCT2 sing N N 416 
PEU CCU OCV  sing N N 417 
PEU CCU HCU1 sing N N 418 
PEU CCU HCU2 sing N N 419 
PEU OCV CCW  sing N N 420 
PEU CCW CCX  sing N N 421 
PEU CCW HCW1 sing N N 422 
PEU CCW HCW2 sing N N 423 
PEU CCX OCY  sing N N 424 
PEU CCX HCX1 sing N N 425 
PEU CCX HCX2 sing N N 426 
PEU OCY CCZ  sing N N 427 
PEU CCZ CDA  sing N N 428 
PEU CCZ HCZ1 sing N N 429 
PEU CCZ HCZ2 sing N N 430 
PEU CDA ODB  sing N N 431 
PEU CDA HDA1 sing N N 432 
PEU CDA HDA2 sing N N 433 
PEU ODB CDC  sing N N 434 
PEU CDC CDD  sing N N 435 
PEU CDC HDC1 sing N N 436 
PEU CDC HDC2 sing N N 437 
PEU CDD ODE  sing N N 438 
PEU CDD HDD1 sing N N 439 
PEU CDD HDD2 sing N N 440 
PEU ODE HDE  sing N N 441 
PHE N   CA   sing N N 442 
PHE N   H    sing N N 443 
PHE N   H2   sing N N 444 
PHE CA  C    sing N N 445 
PHE CA  CB   sing N N 446 
PHE CA  HA   sing N N 447 
PHE C   O    doub N N 448 
PHE C   OXT  sing N N 449 
PHE CB  CG   sing N N 450 
PHE CB  HB2  sing N N 451 
PHE CB  HB3  sing N N 452 
PHE CG  CD1  doub Y N 453 
PHE CG  CD2  sing Y N 454 
PHE CD1 CE1  sing Y N 455 
PHE CD1 HD1  sing N N 456 
PHE CD2 CE2  doub Y N 457 
PHE CD2 HD2  sing N N 458 
PHE CE1 CZ   doub Y N 459 
PHE CE1 HE1  sing N N 460 
PHE CE2 CZ   sing Y N 461 
PHE CE2 HE2  sing N N 462 
PHE CZ  HZ   sing N N 463 
PHE OXT HXT  sing N N 464 
PRO N   CA   sing N N 465 
PRO N   CD   sing N N 466 
PRO N   H    sing N N 467 
PRO CA  C    sing N N 468 
PRO CA  CB   sing N N 469 
PRO CA  HA   sing N N 470 
PRO C   O    doub N N 471 
PRO C   OXT  sing N N 472 
PRO CB  CG   sing N N 473 
PRO CB  HB2  sing N N 474 
PRO CB  HB3  sing N N 475 
PRO CG  CD   sing N N 476 
PRO CG  HG2  sing N N 477 
PRO CG  HG3  sing N N 478 
PRO CD  HD2  sing N N 479 
PRO CD  HD3  sing N N 480 
PRO OXT HXT  sing N N 481 
SER N   CA   sing N N 482 
SER N   H    sing N N 483 
SER N   H2   sing N N 484 
SER CA  C    sing N N 485 
SER CA  CB   sing N N 486 
SER CA  HA   sing N N 487 
SER C   O    doub N N 488 
SER C   OXT  sing N N 489 
SER CB  OG   sing N N 490 
SER CB  HB2  sing N N 491 
SER CB  HB3  sing N N 492 
SER OG  HG   sing N N 493 
SER OXT HXT  sing N N 494 
THR N   CA   sing N N 495 
THR N   H    sing N N 496 
THR N   H2   sing N N 497 
THR CA  C    sing N N 498 
THR CA  CB   sing N N 499 
THR CA  HA   sing N N 500 
THR C   O    doub N N 501 
THR C   OXT  sing N N 502 
THR CB  OG1  sing N N 503 
THR CB  CG2  sing N N 504 
THR CB  HB   sing N N 505 
THR OG1 HG1  sing N N 506 
THR CG2 HG21 sing N N 507 
THR CG2 HG22 sing N N 508 
THR CG2 HG23 sing N N 509 
THR OXT HXT  sing N N 510 
TRP N   CA   sing N N 511 
TRP N   H    sing N N 512 
TRP N   H2   sing N N 513 
TRP CA  C    sing N N 514 
TRP CA  CB   sing N N 515 
TRP CA  HA   sing N N 516 
TRP C   O    doub N N 517 
TRP C   OXT  sing N N 518 
TRP CB  CG   sing N N 519 
TRP CB  HB2  sing N N 520 
TRP CB  HB3  sing N N 521 
TRP CG  CD1  doub Y N 522 
TRP CG  CD2  sing Y N 523 
TRP CD1 NE1  sing Y N 524 
TRP CD1 HD1  sing N N 525 
TRP CD2 CE2  doub Y N 526 
TRP CD2 CE3  sing Y N 527 
TRP NE1 CE2  sing Y N 528 
TRP NE1 HE1  sing N N 529 
TRP CE2 CZ2  sing Y N 530 
TRP CE3 CZ3  doub Y N 531 
TRP CE3 HE3  sing N N 532 
TRP CZ2 CH2  doub Y N 533 
TRP CZ2 HZ2  sing N N 534 
TRP CZ3 CH2  sing Y N 535 
TRP CZ3 HZ3  sing N N 536 
TRP CH2 HH2  sing N N 537 
TRP OXT HXT  sing N N 538 
TYR N   CA   sing N N 539 
TYR N   H    sing N N 540 
TYR N   H2   sing N N 541 
TYR CA  C    sing N N 542 
TYR CA  CB   sing N N 543 
TYR CA  HA   sing N N 544 
TYR C   O    doub N N 545 
TYR C   OXT  sing N N 546 
TYR CB  CG   sing N N 547 
TYR CB  HB2  sing N N 548 
TYR CB  HB3  sing N N 549 
TYR CG  CD1  doub Y N 550 
TYR CG  CD2  sing Y N 551 
TYR CD1 CE1  sing Y N 552 
TYR CD1 HD1  sing N N 553 
TYR CD2 CE2  doub Y N 554 
TYR CD2 HD2  sing N N 555 
TYR CE1 CZ   doub Y N 556 
TYR CE1 HE1  sing N N 557 
TYR CE2 CZ   sing Y N 558 
TYR CE2 HE2  sing N N 559 
TYR CZ  OH   sing N N 560 
TYR OH  HH   sing N N 561 
TYR OXT HXT  sing N N 562 
VAL N   CA   sing N N 563 
VAL N   H    sing N N 564 
VAL N   H2   sing N N 565 
VAL CA  C    sing N N 566 
VAL CA  CB   sing N N 567 
VAL CA  HA   sing N N 568 
VAL C   O    doub N N 569 
VAL C   OXT  sing N N 570 
VAL CB  CG1  sing N N 571 
VAL CB  CG2  sing N N 572 
VAL CB  HB   sing N N 573 
VAL CG1 HG11 sing N N 574 
VAL CG1 HG12 sing N N 575 
VAL CG1 HG13 sing N N 576 
VAL CG2 HG21 sing N N 577 
VAL CG2 HG22 sing N N 578 
VAL CG2 HG23 sing N N 579 
VAL OXT HXT  sing N N 580 
# 
_pdbx_audit_support.funding_organization   'Ministry of Science and Technology (MoST, Taiwan)' 
_pdbx_audit_support.country                Taiwan 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6VL9 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8Z95 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.004076 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001622 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.022949 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009771 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 1   ? -31.557 8.800   -7.709  1.00 58.33  ? 1   GLN A N   1 
ATOM   2    C CA  . GLN A 1 1   ? -32.629 8.366   -8.648  1.00 58.22  ? 1   GLN A CA  1 
ATOM   3    C C   . GLN A 1 1   ? -32.768 6.851   -8.559  1.00 49.00  ? 1   GLN A C   1 
ATOM   4    O O   . GLN A 1 1   ? -33.842 6.329   -8.273  1.00 48.85  ? 1   GLN A O   1 
ATOM   5    C CB  . GLN A 1 1   ? -32.321 8.776   -10.095 1.00 63.11  ? 1   GLN A CB  1 
ATOM   6    C CG  . GLN A 1 1   ? -32.117 10.273  -10.300 1.00 72.47  ? 1   GLN A CG  1 
ATOM   7    C CD  . GLN A 1 1   ? -33.411 11.043  -10.416 1.00 77.14  ? 1   GLN A CD  1 
ATOM   8    O OE1 . GLN A 1 1   ? -34.322 10.892  -9.608  1.00 78.68  ? 1   GLN A OE1 1 
ATOM   9    N NE2 . GLN A 1 1   ? -33.501 11.889  -11.430 1.00 79.13  ? 1   GLN A NE2 1 
ATOM   10   N N   . VAL A 1 2   ? -31.656 6.157   -8.812  1.00 45.32  ? 2   VAL A N   1 
ATOM   11   C CA  . VAL A 1 2   ? -31.660 4.708   -8.879  1.00 40.22  ? 2   VAL A CA  1 
ATOM   12   C C   . VAL A 1 2   ? -31.852 4.135   -7.484  1.00 35.62  ? 2   VAL A C   1 
ATOM   13   O O   . VAL A 1 2   ? -31.158 4.524   -6.554  1.00 33.81  ? 2   VAL A O   1 
ATOM   14   C CB  . VAL A 1 2   ? -30.376 4.147   -9.510  1.00 35.13  ? 2   VAL A CB  1 
ATOM   15   C CG1 . VAL A 1 2   ? -30.325 2.646   -9.345  1.00 35.81  ? 2   VAL A CG1 1 
ATOM   16   C CG2 . VAL A 1 2   ? -30.256 4.526   -10.974 1.00 35.39  ? 2   VAL A CG2 1 
ATOM   17   N N   . GLN A 1 3   ? -32.745 3.149   -7.397  1.00 34.58  ? 3   GLN A N   1 
ATOM   18   C CA  . GLN A 1 3   ? -33.147 2.556   -6.138  1.00 38.98  ? 3   GLN A CA  1 
ATOM   19   C C   . GLN A 1 3   ? -33.319 1.066   -6.384  1.00 35.24  ? 3   GLN A C   1 
ATOM   20   O O   . GLN A 1 3   ? -33.944 0.701   -7.379  1.00 34.80  ? 3   GLN A O   1 
ATOM   21   C CB  . GLN A 1 3   ? -34.503 3.137   -5.711  1.00 46.04  ? 3   GLN A CB  1 
ATOM   22   C CG  . GLN A 1 3   ? -34.548 3.648   -4.284  1.00 50.62  ? 3   GLN A CG  1 
ATOM   23   C CD  . GLN A 1 3   ? -33.980 5.043   -4.207  1.00 54.75  ? 3   GLN A CD  1 
ATOM   24   O OE1 . GLN A 1 3   ? -34.629 6.004   -4.603  1.00 59.46  ? 3   GLN A OE1 1 
ATOM   25   N NE2 . GLN A 1 3   ? -32.764 5.169   -3.698  1.00 55.08  ? 3   GLN A NE2 1 
ATOM   26   N N   . LEU A 1 4   ? -32.791 0.222   -5.488  1.00 33.92  ? 4   LEU A N   1 
ATOM   27   C CA  . LEU A 1 4   ? -33.143 -1.195  -5.467  1.00 31.21  ? 4   LEU A CA  1 
ATOM   28   C C   . LEU A 1 4   ? -33.798 -1.504  -4.122  1.00 31.48  ? 4   LEU A C   1 
ATOM   29   O O   . LEU A 1 4   ? -33.150 -1.422  -3.086  1.00 31.94  ? 4   LEU A O   1 
ATOM   30   C CB  . LEU A 1 4   ? -31.887 -2.064  -5.663  1.00 29.46  ? 4   LEU A CB  1 
ATOM   31   C CG  . LEU A 1 4   ? -31.055 -1.829  -6.930  1.00 27.61  ? 4   LEU A CG  1 
ATOM   32   C CD1 . LEU A 1 4   ? -29.976 -2.883  -7.086  1.00 28.57  ? 4   LEU A CD1 1 
ATOM   33   C CD2 . LEU A 1 4   ? -31.914 -1.806  -8.171  1.00 28.75  ? 4   LEU A CD2 1 
ATOM   34   N N   . VAL A 1 5   ? -35.080 -1.858  -4.121  1.00 30.69  ? 5   VAL A N   1 
ATOM   35   C CA  . VAL A 1 5   ? -35.784 -2.031  -2.857  1.00 32.01  ? 5   VAL A CA  1 
ATOM   36   C C   . VAL A 1 5   ? -36.234 -3.482  -2.738  1.00 26.60  ? 5   VAL A C   1 
ATOM   37   O O   . VAL A 1 5   ? -36.816 -4.041  -3.653  1.00 30.64  ? 5   VAL A O   1 
ATOM   38   C CB  . VAL A 1 5   ? -36.928 -1.003  -2.688  1.00 33.85  ? 5   VAL A CB  1 
ATOM   39   C CG1 . VAL A 1 5   ? -37.622 -1.117  -1.333  1.00 36.16  ? 5   VAL A CG1 1 
ATOM   40   C CG2 . VAL A 1 5   ? -36.410 0.416   -2.870  1.00 32.41  ? 5   VAL A CG2 1 
ATOM   41   N N   . GLN A 1 6   ? -35.882 -4.120  -1.623  1.00 28.03  ? 6   GLN A N   1 
ATOM   42   C CA  . GLN A 1 6   ? -36.068 -5.556  -1.480  1.00 31.54  ? 6   GLN A CA  1 
ATOM   43   C C   . GLN A 1 6   ? -37.245 -5.792  -0.551  1.00 31.77  ? 6   GLN A C   1 
ATOM   44   O O   . GLN A 1 6   ? -37.637 -4.866  0.128   1.00 33.72  ? 6   GLN A O   1 
ATOM   45   C CB  . GLN A 1 6   ? -34.828 -6.215  -0.878  1.00 31.86  ? 6   GLN A CB  1 
ATOM   46   C CG  . GLN A 1 6   ? -33.588 -6.077  -1.755  1.00 33.28  ? 6   GLN A CG  1 
ATOM   47   C CD  . GLN A 1 6   ? -32.410 -6.910  -1.301  1.00 30.33  ? 6   GLN A CD  1 
ATOM   48   O OE1 . GLN A 1 6   ? -31.283 -6.438  -1.305  1.00 29.63  ? 6   GLN A OE1 1 
ATOM   49   N NE2 . GLN A 1 6   ? -32.646 -8.171  -0.965  1.00 30.45  ? 6   GLN A NE2 1 
ATOM   50   N N   . SER A 1 7   ? -37.764 -7.022  -0.536  1.00 35.90  ? 7   SER A N   1 
ATOM   51   C CA  . SER A 1 7   ? -38.833 -7.431  0.364   1.00 42.43  ? 7   SER A CA  1 
ATOM   52   C C   . SER A 1 7   ? -38.321 -7.529  1.802   1.00 44.11  ? 7   SER A C   1 
ATOM   53   O O   . SER A 1 7   ? -37.117 -7.428  2.054   1.00 44.22  ? 7   SER A O   1 
ATOM   54   C CB  . SER A 1 7   ? -39.421 -8.746  -0.092  1.00 40.97  ? 7   SER A CB  1 
ATOM   55   O OG  . SER A 1 7   ? -38.392 -9.682  -0.372  1.00 41.85  ? 7   SER A OG  1 
ATOM   56   N N   . GLY A 1 8   ? -39.252 -7.775  2.733   1.00 40.14  ? 8   GLY A N   1 
ATOM   57   C CA  . GLY A 1 8   ? -38.969 -7.703  4.158   1.00 35.29  ? 8   GLY A CA  1 
ATOM   58   C C   . GLY A 1 8   ? -38.470 -9.035  4.709   1.00 34.22  ? 8   GLY A C   1 
ATOM   59   O O   . GLY A 1 8   ? -38.507 -10.059 4.025   1.00 31.31  ? 8   GLY A O   1 
ATOM   60   N N   . SER A 1 9   ? -38.020 -8.994  5.969   1.00 34.21  ? 9   SER A N   1 
ATOM   61   C CA  . SER A 1 9   ? -37.490 -10.158 6.661   1.00 37.13  ? 9   SER A CA  1 
ATOM   62   C C   . SER A 1 9   ? -38.485 -11.311 6.615   1.00 41.63  ? 9   SER A C   1 
ATOM   63   O O   . SER A 1 9   ? -39.695 -11.119 6.479   1.00 43.22  ? 9   SER A O   1 
ATOM   64   C CB  . SER A 1 9   ? -37.135 -9.818  8.083   1.00 38.27  ? 9   SER A CB  1 
ATOM   65   O OG  . SER A 1 9   ? -36.656 -8.478  8.159   1.00 39.90  ? 9   SER A OG  1 
ATOM   66   N N   . GLU A 1 10  ? -37.947 -12.519 6.727   1.00 42.61  ? 10  GLU A N   1 
ATOM   67   C CA  . GLU A 1 10  ? -38.731 -13.727 6.607   1.00 47.37  ? 10  GLU A CA  1 
ATOM   68   C C   . GLU A 1 10  ? -38.192 -14.690 7.647   1.00 47.72  ? 10  GLU A C   1 
ATOM   69   O O   . GLU A 1 10  ? -36.978 -14.816 7.785   1.00 48.14  ? 10  GLU A O   1 
ATOM   70   C CB  . GLU A 1 10  ? -38.614 -14.327 5.202   1.00 55.59  ? 10  GLU A CB  1 
ATOM   71   C CG  . GLU A 1 10  ? -39.287 -13.520 4.097   1.00 62.69  ? 10  GLU A CG  1 
ATOM   72   C CD  . GLU A 1 10  ? -40.768 -13.783 3.861   1.00 70.83  ? 10  GLU A CD  1 
ATOM   73   O OE1 . GLU A 1 10  ? -41.349 -14.631 4.571   1.00 79.47  ? 10  GLU A OE1 1 
ATOM   74   O OE2 . GLU A 1 10  ? -41.343 -13.136 2.956   1.00 71.14  ? 10  GLU A OE2 1 
ATOM   75   N N   . LEU A 1 11  ? -39.110 -15.304 8.397   1.00 50.78  ? 11  LEU A N   1 
ATOM   76   C CA  . LEU A 1 11  ? -38.803 -16.430 9.257   1.00 50.46  ? 11  LEU A CA  1 
ATOM   77   C C   . LEU A 1 11  ? -39.379 -17.672 8.600   1.00 43.72  ? 11  LEU A C   1 
ATOM   78   O O   . LEU A 1 11  ? -40.568 -17.707 8.328   1.00 42.47  ? 11  LEU A O   1 
ATOM   79   C CB  . LEU A 1 11  ? -39.424 -16.211 10.640  1.00 55.25  ? 11  LEU A CB  1 
ATOM   80   C CG  . LEU A 1 11  ? -39.517 -17.461 11.518  1.00 60.36  ? 11  LEU A CG  1 
ATOM   81   C CD1 . LEU A 1 11  ? -38.158 -18.129 11.703  1.00 61.77  ? 11  LEU A CD1 1 
ATOM   82   C CD2 . LEU A 1 11  ? -40.112 -17.119 12.869  1.00 65.91  ? 11  LEU A CD2 1 
ATOM   83   N N   . LYS A 1 12  ? -38.534 -18.672 8.337   1.00 43.92  ? 12  LYS A N   1 
ATOM   84   C CA  . LYS A 1 12  ? -38.967 -19.877 7.652   1.00 44.14  ? 12  LYS A CA  1 
ATOM   85   C C   . LYS A 1 12  ? -38.570 -21.088 8.473   1.00 46.02  ? 12  LYS A C   1 
ATOM   86   O O   . LYS A 1 12  ? -37.556 -21.073 9.156   1.00 51.33  ? 12  LYS A O   1 
ATOM   87   C CB  . LYS A 1 12  ? -38.331 -19.983 6.262   1.00 45.75  ? 12  LYS A CB  1 
ATOM   88   C CG  . LYS A 1 12  ? -38.776 -18.909 5.283   1.00 46.80  ? 12  LYS A CG  1 
ATOM   89   C CD  . LYS A 1 12  ? -40.198 -19.108 4.794   1.00 51.87  ? 12  LYS A CD  1 
ATOM   90   C CE  . LYS A 1 12  ? -40.851 -17.818 4.349   1.00 54.51  ? 12  LYS A CE  1 
ATOM   91   N NZ  . LYS A 1 12  ? -42.087 -18.097 3.580   1.00 60.74  ? 12  LYS A NZ  1 
ATOM   92   N N   . LYS A 1 13  ? -39.369 -22.144 8.365   1.00 53.23  ? 13  LYS A N   1 
ATOM   93   C CA  . LYS A 1 13  ? -39.059 -23.395 9.028   1.00 56.46  ? 13  LYS A CA  1 
ATOM   94   C C   . LYS A 1 13  ? -38.238 -24.231 8.059   1.00 50.04  ? 13  LYS A C   1 
ATOM   95   O O   . LYS A 1 13  ? -38.422 -24.119 6.852   1.00 52.01  ? 13  LYS A O   1 
ATOM   96   C CB  . LYS A 1 13  ? -40.362 -24.051 9.496   1.00 63.53  ? 13  LYS A CB  1 
ATOM   97   C CG  . LYS A 1 13  ? -41.166 -23.164 10.437  1.00 67.92  ? 13  LYS A CG  1 
ATOM   98   C CD  . LYS A 1 13  ? -42.354 -23.810 11.106  1.00 71.14  ? 13  LYS A CD  1 
ATOM   99   C CE  . LYS A 1 13  ? -42.664 -23.130 12.425  1.00 74.07  ? 13  LYS A CE  1 
ATOM   100  N NZ  . LYS A 1 13  ? -44.090 -23.258 12.800  1.00 79.48  ? 13  LYS A NZ  1 
ATOM   101  N N   . PRO A 1 14  ? -37.281 -25.054 8.540   1.00 45.57  ? 14  PRO A N   1 
ATOM   102  C CA  . PRO A 1 14  ? -36.558 -25.973 7.665   1.00 45.47  ? 14  PRO A CA  1 
ATOM   103  C C   . PRO A 1 14  ? -37.488 -26.686 6.689   1.00 47.58  ? 14  PRO A C   1 
ATOM   104  O O   . PRO A 1 14  ? -38.636 -26.966 7.033   1.00 53.65  ? 14  PRO A O   1 
ATOM   105  C CB  . PRO A 1 14  ? -35.907 -26.938 8.659   1.00 41.96  ? 14  PRO A CB  1 
ATOM   106  C CG  . PRO A 1 14  ? -35.624 -26.059 9.854   1.00 44.18  ? 14  PRO A CG  1 
ATOM   107  C CD  . PRO A 1 14  ? -36.807 -25.114 9.930   1.00 43.79  ? 14  PRO A CD  1 
ATOM   108  N N   . GLY A 1 15  ? -36.987 -26.924 5.466   1.00 49.96  ? 15  GLY A N   1 
ATOM   109  C CA  . GLY A 1 15  ? -37.717 -27.641 4.429   1.00 49.72  ? 15  GLY A CA  1 
ATOM   110  C C   . GLY A 1 15  ? -38.543 -26.741 3.505   1.00 47.52  ? 15  GLY A C   1 
ATOM   111  O O   . GLY A 1 15  ? -38.801 -27.109 2.361   1.00 52.03  ? 15  GLY A O   1 
ATOM   112  N N   . ALA A 1 16  ? -38.974 -25.572 3.995   1.00 46.89  ? 16  ALA A N   1 
ATOM   113  C CA  . ALA A 1 16  ? -39.815 -24.673 3.215   1.00 48.53  ? 16  ALA A CA  1 
ATOM   114  C C   . ALA A 1 16  ? -39.000 -23.958 2.129   1.00 45.96  ? 16  ALA A C   1 
ATOM   115  O O   . ALA A 1 16  ? -37.807 -24.218 1.944   1.00 44.51  ? 16  ALA A O   1 
ATOM   116  C CB  . ALA A 1 16  ? -40.494 -23.682 4.147   1.00 47.27  ? 16  ALA A CB  1 
ATOM   117  N N   . SER A 1 17  ? -39.691 -23.046 1.429   1.00 46.57  ? 17  SER A N   1 
ATOM   118  C CA  . SER A 1 17  ? -39.155 -22.237 0.347   1.00 48.59  ? 17  SER A CA  1 
ATOM   119  C C   . SER A 1 17  ? -39.377 -20.763 0.657   1.00 49.96  ? 17  SER A C   1 
ATOM   120  O O   . SER A 1 17  ? -40.237 -20.423 1.467   1.00 51.04  ? 17  SER A O   1 
ATOM   121  C CB  . SER A 1 17  ? -39.807 -22.592 -0.965  1.00 50.00  ? 17  SER A CB  1 
ATOM   122  O OG  . SER A 1 17  ? -39.215 -23.755 -1.527  1.00 55.61  ? 17  SER A OG  1 
ATOM   123  N N   . VAL A 1 18  ? -38.614 -19.891 -0.017  1.00 50.07  ? 18  VAL A N   1 
ATOM   124  C CA  . VAL A 1 18  ? -38.744 -18.459 0.198   1.00 44.07  ? 18  VAL A CA  1 
ATOM   125  C C   . VAL A 1 18  ? -38.478 -17.719 -1.112  1.00 43.75  ? 18  VAL A C   1 
ATOM   126  O O   . VAL A 1 18  ? -37.756 -18.201 -1.987  1.00 42.58  ? 18  VAL A O   1 
ATOM   127  C CB  . VAL A 1 18  ? -37.823 -17.976 1.335   1.00 41.83  ? 18  VAL A CB  1 
ATOM   128  C CG1 . VAL A 1 18  ? -36.351 -18.010 0.943   1.00 43.88  ? 18  VAL A CG1 1 
ATOM   129  C CG2 . VAL A 1 18  ? -38.216 -16.590 1.833   1.00 41.78  ? 18  VAL A CG2 1 
ATOM   130  N N   . LYS A 1 19  ? -39.061 -16.523 -1.217  1.00 42.45  ? 19  LYS A N   1 
ATOM   131  C CA  . LYS A 1 19  ? -38.994 -15.753 -2.442  1.00 44.29  ? 19  LYS A CA  1 
ATOM   132  C C   . LYS A 1 19  ? -38.784 -14.293 -2.087  1.00 42.44  ? 19  LYS A C   1 
ATOM   133  O O   . LYS A 1 19  ? -39.724 -13.584 -1.749  1.00 49.94  ? 19  LYS A O   1 
ATOM   134  C CB  . LYS A 1 19  ? -40.255 -15.927 -3.291  1.00 47.03  ? 19  LYS A CB  1 
ATOM   135  C CG  . LYS A 1 19  ? -40.173 -15.264 -4.660  1.00 52.97  ? 19  LYS A CG  1 
ATOM   136  C CD  . LYS A 1 19  ? -41.201 -15.767 -5.647  1.00 61.22  ? 19  LYS A CD  1 
ATOM   137  C CE  . LYS A 1 19  ? -40.812 -15.482 -7.083  1.00 65.19  ? 19  LYS A CE  1 
ATOM   138  N NZ  . LYS A 1 19  ? -41.749 -16.121 -8.031  1.00 63.30  ? 19  LYS A NZ  1 
ATOM   139  N N   . VAL A 1 20  ? -37.529 -13.864 -2.194  1.00 43.57  ? 20  VAL A N   1 
ATOM   140  C CA  . VAL A 1 20  ? -37.142 -12.489 -1.960  1.00 39.57  ? 20  VAL A CA  1 
ATOM   141  C C   . VAL A 1 20  ? -37.299 -11.737 -3.274  1.00 36.29  ? 20  VAL A C   1 
ATOM   142  O O   . VAL A 1 20  ? -36.933 -12.255 -4.323  1.00 34.93  ? 20  VAL A O   1 
ATOM   143  C CB  . VAL A 1 20  ? -35.688 -12.442 -1.469  1.00 43.38  ? 20  VAL A CB  1 
ATOM   144  C CG1 . VAL A 1 20  ? -35.202 -11.009 -1.286  1.00 46.28  ? 20  VAL A CG1 1 
ATOM   145  C CG2 . VAL A 1 20  ? -35.524 -13.274 -0.205  1.00 45.19  ? 20  VAL A CG2 1 
ATOM   146  N N   . SER A 1 21  ? -37.851 -10.529 -3.204  1.00 37.16  ? 21  SER A N   1 
ATOM   147  C CA  . SER A 1 21  ? -37.984 -9.690  -4.379  1.00 39.47  ? 21  SER A CA  1 
ATOM   148  C C   . SER A 1 21  ? -37.021 -8.510  -4.261  1.00 33.84  ? 21  SER A C   1 
ATOM   149  O O   . SER A 1 21  ? -36.625 -8.121  -3.173  1.00 29.50  ? 21  SER A O   1 
ATOM   150  C CB  . SER A 1 21  ? -39.403 -9.249  -4.573  1.00 38.44  ? 21  SER A CB  1 
ATOM   151  O OG  . SER A 1 21  ? -39.850 -8.529  -3.443  1.00 43.62  ? 21  SER A OG  1 
ATOM   152  N N   . CYS A 1 22  ? -36.602 -8.004  -5.416  1.00 35.21  ? 22  CYS A N   1 
ATOM   153  C CA  . CYS A 1 22  ? -35.772 -6.817  -5.519  1.00 35.02  ? 22  CYS A CA  1 
ATOM   154  C C   . CYS A 1 22  ? -36.371 -5.918  -6.595  1.00 31.97  ? 22  CYS A C   1 
ATOM   155  O O   . CYS A 1 22  ? -36.278 -6.237  -7.776  1.00 32.80  ? 22  CYS A O   1 
ATOM   156  C CB  . CYS A 1 22  ? -34.334 -7.203  -5.859  1.00 34.17  ? 22  CYS A CB  1 
ATOM   157  S SG  . CYS A 1 22  ? -33.292 -5.795  -6.333  1.00 37.44  ? 22  CYS A SG  1 
ATOM   158  N N   . LYS A 1 23  ? -37.008 -4.815  -6.193  1.00 34.01  ? 23  LYS A N   1 
ATOM   159  C CA  . LYS A 1 23  ? -37.677 -3.955  -7.157  1.00 35.51  ? 23  LYS A CA  1 
ATOM   160  C C   . LYS A 1 23  ? -36.770 -2.788  -7.509  1.00 32.47  ? 23  LYS A C   1 
ATOM   161  O O   . LYS A 1 23  ? -36.436 -1.993  -6.643  1.00 33.47  ? 23  LYS A O   1 
ATOM   162  C CB  . LYS A 1 23  ? -38.984 -3.363  -6.619  1.00 41.64  ? 23  LYS A CB  1 
ATOM   163  C CG  . LYS A 1 23  ? -39.481 -2.151  -7.405  1.00 48.39  ? 23  LYS A CG  1 
ATOM   164  C CD  . LYS A 1 23  ? -40.652 -1.411  -6.786  1.00 59.32  ? 23  LYS A CD  1 
ATOM   165  C CE  . LYS A 1 23  ? -41.988 -2.075  -7.051  1.00 64.93  ? 23  LYS A CE  1 
ATOM   166  N NZ  . LYS A 1 23  ? -42.357 -2.018  -8.485  1.00 67.58  ? 23  LYS A NZ  1 
ATOM   167  N N   . ALA A 1 24  ? -36.460 -2.644  -8.796  1.00 31.35  ? 24  ALA A N   1 
ATOM   168  C CA  . ALA A 1 24  ? -35.579 -1.596  -9.257  1.00 32.46  ? 24  ALA A CA  1 
ATOM   169  C C   . ALA A 1 24  ? -36.400 -0.477  -9.882  1.00 30.98  ? 24  ALA A C   1 
ATOM   170  O O   . ALA A 1 24  ? -37.395 -0.715  -10.553 1.00 34.88  ? 24  ALA A O   1 
ATOM   171  C CB  . ALA A 1 24  ? -34.597 -2.152  -10.263 1.00 35.17  ? 24  ALA A CB  1 
ATOM   172  N N   . SER A 1 25  ? -35.912 0.740   -9.719  1.00 27.00  ? 25  SER A N   1 
ATOM   173  C CA  . SER A 1 25  ? -36.537 1.887   -10.337 1.00 31.82  ? 25  SER A CA  1 
ATOM   174  C C   . SER A 1 25  ? -35.431 2.887   -10.677 1.00 29.36  ? 25  SER A C   1 
ATOM   175  O O   . SER A 1 25  ? -34.329 2.770   -10.161 1.00 28.55  ? 25  SER A O   1 
ATOM   176  C CB  . SER A 1 25  ? -37.597 2.462   -9.404  1.00 31.40  ? 25  SER A CB  1 
ATOM   177  O OG  . SER A 1 25  ? -36.984 3.154   -8.328  1.00 31.44  ? 25  SER A OG  1 
ATOM   178  N N   . GLY A 1 26  ? -35.726 3.846   -11.557 1.00 28.18  ? 26  GLY A N   1 
ATOM   179  C CA  . GLY A 1 26  ? -34.809 4.926   -11.864 1.00 28.47  ? 26  GLY A CA  1 
ATOM   180  C C   . GLY A 1 26  ? -33.899 4.639   -13.066 1.00 28.65  ? 26  GLY A C   1 
ATOM   181  O O   . GLY A 1 26  ? -33.054 5.468   -13.369 1.00 30.84  ? 26  GLY A O   1 
ATOM   182  N N   . TYR A 1 27  ? -34.069 3.497   -13.756 1.00 28.13  ? 27  TYR A N   1 
ATOM   183  C CA  . TYR A 1 27  ? -33.256 3.157   -14.922 1.00 28.00  ? 27  TYR A CA  1 
ATOM   184  C C   . TYR A 1 27  ? -33.968 2.073   -15.724 1.00 31.35  ? 27  TYR A C   1 
ATOM   185  O O   . TYR A 1 27  ? -34.840 1.369   -15.214 1.00 35.42  ? 27  TYR A O   1 
ATOM   186  C CB  . TYR A 1 27  ? -31.844 2.674   -14.526 1.00 26.91  ? 27  TYR A CB  1 
ATOM   187  C CG  . TYR A 1 27  ? -31.802 1.325   -13.853 1.00 24.91  ? 27  TYR A CG  1 
ATOM   188  C CD1 . TYR A 1 27  ? -32.001 1.180   -12.483 1.00 25.43  ? 27  TYR A CD1 1 
ATOM   189  C CD2 . TYR A 1 27  ? -31.687 0.164   -14.602 1.00 24.96  ? 27  TYR A CD2 1 
ATOM   190  C CE1 . TYR A 1 27  ? -32.025 -0.073  -11.879 1.00 22.71  ? 27  TYR A CE1 1 
ATOM   191  C CE2 . TYR A 1 27  ? -31.686 -1.093  -14.013 1.00 23.02  ? 27  TYR A CE2 1 
ATOM   192  C CZ  . TYR A 1 27  ? -31.854 -1.216  -12.643 1.00 23.65  ? 27  TYR A CZ  1 
ATOM   193  O OH  . TYR A 1 27  ? -31.890 -2.476  -12.083 1.00 22.42  ? 27  TYR A OH  1 
ATOM   194  N N   . THR A 1 28  ? -33.534 1.895   -16.968 1.00 33.11  ? 28  THR A N   1 
ATOM   195  C CA  . THR A 1 28  ? -34.061 0.840   -17.817 1.00 33.54  ? 28  THR A CA  1 
ATOM   196  C C   . THR A 1 28  ? -33.581 -0.529  -17.340 1.00 33.55  ? 28  THR A C   1 
ATOM   197  O O   . THR A 1 28  ? -32.457 -0.950  -17.625 1.00 32.78  ? 28  THR A O   1 
ATOM   198  C CB  . THR A 1 28  ? -33.659 1.026   -19.281 1.00 33.38  ? 28  THR A CB  1 
ATOM   199  O OG1 . THR A 1 28  ? -33.857 2.396   -19.592 1.00 29.60  ? 28  THR A OG1 1 
ATOM   200  C CG2 . THR A 1 28  ? -34.465 0.158   -20.218 1.00 34.84  ? 28  THR A CG2 1 
ATOM   201  N N   . PHE A 1 29  ? -34.525 -1.231  -16.711 1.00 32.25  ? 29  PHE A N   1 
ATOM   202  C CA  . PHE A 1 29  ? -34.325 -2.483  -16.018 1.00 31.10  ? 29  PHE A CA  1 
ATOM   203  C C   . PHE A 1 29  ? -33.519 -3.504  -16.816 1.00 30.01  ? 29  PHE A C   1 
ATOM   204  O O   . PHE A 1 29  ? -32.718 -4.251  -16.240 1.00 29.19  ? 29  PHE A O   1 
ATOM   205  C CB  . PHE A 1 29  ? -35.690 -3.099  -15.725 1.00 30.27  ? 29  PHE A CB  1 
ATOM   206  C CG  . PHE A 1 29  ? -35.591 -4.383  -14.952 1.00 31.18  ? 29  PHE A CG  1 
ATOM   207  C CD1 . PHE A 1 29  ? -35.057 -4.386  -13.675 1.00 31.04  ? 29  PHE A CD1 1 
ATOM   208  C CD2 . PHE A 1 29  ? -35.998 -5.581  -15.509 1.00 32.52  ? 29  PHE A CD2 1 
ATOM   209  C CE1 . PHE A 1 29  ? -34.977 -5.561  -12.948 1.00 32.99  ? 29  PHE A CE1 1 
ATOM   210  C CE2 . PHE A 1 29  ? -35.912 -6.757  -14.781 1.00 35.46  ? 29  PHE A CE2 1 
ATOM   211  C CZ  . PHE A 1 29  ? -35.402 -6.745  -13.500 1.00 35.28  ? 29  PHE A CZ  1 
ATOM   212  N N   . THR A 1 30  ? -33.817 -3.593  -18.116 1.00 26.74  ? 30  THR A N   1 
ATOM   213  C CA  . THR A 1 30  ? -33.316 -4.666  -18.953 1.00 26.30  ? 30  THR A CA  1 
ATOM   214  C C   . THR A 1 30  ? -31.962 -4.323  -19.582 1.00 25.67  ? 30  THR A C   1 
ATOM   215  O O   . THR A 1 30  ? -31.423 -5.133  -20.328 1.00 24.25  ? 30  THR A O   1 
ATOM   216  C CB  . THR A 1 30  ? -34.366 -4.990  -20.020 1.00 29.05  ? 30  THR A CB  1 
ATOM   217  O OG1 . THR A 1 30  ? -34.615 -3.775  -20.725 1.00 28.69  ? 30  THR A OG1 1 
ATOM   218  C CG2 . THR A 1 30  ? -35.659 -5.499  -19.418 1.00 28.97  ? 30  THR A CG2 1 
ATOM   219  N N   . ASN A 1 31  ? -31.400 -3.146  -19.277 1.00 26.01  ? 31  ASN A N   1 
ATOM   220  C CA  . ASN A 1 31  ? -30.096 -2.759  -19.795 1.00 28.40  ? 31  ASN A CA  1 
ATOM   221  C C   . ASN A 1 31  ? -28.945 -3.181  -18.880 1.00 28.51  ? 31  ASN A C   1 
ATOM   222  O O   . ASN A 1 31  ? -27.787 -3.001  -19.250 1.00 24.88  ? 31  ASN A O   1 
ATOM   223  C CB  . ASN A 1 31  ? -29.946 -1.250  -19.933 1.00 25.62  ? 31  ASN A CB  1 
ATOM   224  C CG  . ASN A 1 31  ? -30.593 -0.721  -21.175 1.00 28.72  ? 31  ASN A CG  1 
ATOM   225  O OD1 . ASN A 1 31  ? -30.977 -1.493  -22.058 1.00 36.17  ? 31  ASN A OD1 1 
ATOM   226  N ND2 . ASN A 1 31  ? -30.730 0.591   -21.229 1.00 27.46  ? 31  ASN A ND2 1 
ATOM   227  N N   . TYR A 1 32  ? -29.274 -3.666  -17.678 1.00 29.32  ? 32  TYR A N   1 
ATOM   228  C CA  . TYR A 1 32  ? -28.276 -3.981  -16.668 1.00 25.86  ? 32  TYR A CA  1 
ATOM   229  C C   . TYR A 1 32  ? -28.627 -5.314  -16.028 1.00 25.56  ? 32  TYR A C   1 
ATOM   230  O O   . TYR A 1 32  ? -29.765 -5.528  -15.623 1.00 27.78  ? 32  TYR A O   1 
ATOM   231  C CB  . TYR A 1 32  ? -28.232 -2.904  -15.582 1.00 26.05  ? 32  TYR A CB  1 
ATOM   232  C CG  . TYR A 1 32  ? -27.829 -1.533  -16.058 1.00 25.78  ? 32  TYR A CG  1 
ATOM   233  C CD1 . TYR A 1 32  ? -28.733 -0.679  -16.681 1.00 27.79  ? 32  TYR A CD1 1 
ATOM   234  C CD2 . TYR A 1 32  ? -26.506 -1.120  -15.969 1.00 25.00  ? 32  TYR A CD2 1 
ATOM   235  C CE1 . TYR A 1 32  ? -28.337 0.565   -17.170 1.00 26.94  ? 32  TYR A CE1 1 
ATOM   236  C CE2 . TYR A 1 32  ? -26.101 0.121   -16.430 1.00 25.10  ? 32  TYR A CE2 1 
ATOM   237  C CZ  . TYR A 1 32  ? -27.017 0.963   -17.039 1.00 26.79  ? 32  TYR A CZ  1 
ATOM   238  O OH  . TYR A 1 32  ? -26.564 2.179   -17.493 1.00 31.89  ? 32  TYR A OH  1 
ATOM   239  N N   . GLY A 1 33  ? -27.628 -6.187  -15.901 1.00 24.93  ? 33  GLY A N   1 
ATOM   240  C CA  . GLY A 1 33  ? -27.824 -7.469  -15.250 1.00 25.04  ? 33  GLY A CA  1 
ATOM   241  C C   . GLY A 1 33  ? -27.988 -7.300  -13.744 1.00 22.64  ? 33  GLY A C   1 
ATOM   242  O O   . GLY A 1 33  ? -27.742 -6.239  -13.206 1.00 19.37  ? 33  GLY A O   1 
ATOM   243  N N   . MET A 1 34  ? -28.412 -8.356  -13.057 1.00 23.72  ? 34  MET A N   1 
ATOM   244  C CA  . MET A 1 34  ? -28.618 -8.245  -11.620 1.00 26.83  ? 34  MET A CA  1 
ATOM   245  C C   . MET A 1 34  ? -27.837 -9.357  -10.917 1.00 23.14  ? 34  MET A C   1 
ATOM   246  O O   . MET A 1 34  ? -27.754 -10.478 -11.416 1.00 21.31  ? 34  MET A O   1 
ATOM   247  C CB  . MET A 1 34  ? -30.111 -8.285  -11.275 1.00 28.28  ? 34  MET A CB  1 
ATOM   248  C CG  . MET A 1 34  ? -30.402 -7.941  -9.822  1.00 30.94  ? 34  MET A CG  1 
ATOM   249  S SD  . MET A 1 34  ? -30.145 -6.187  -9.470  1.00 34.95  ? 34  MET A SD  1 
ATOM   250  C CE  . MET A 1 34  ? -31.675 -5.544  -10.144 1.00 35.99  ? 34  MET A CE  1 
ATOM   251  N N   . ASN A 1 35  ? -27.148 -8.997  -9.827  1.00 21.63  ? 35  ASN A N   1 
ATOM   252  C CA  . ASN A 1 35  ? -26.431 -9.981  -9.029  1.00 21.71  ? 35  ASN A CA  1 
ATOM   253  C C   . ASN A 1 35  ? -27.153 -10.205 -7.689  1.00 23.71  ? 35  ASN A C   1 
ATOM   254  O O   . ASN A 1 35  ? -27.811 -9.306  -7.134  1.00 22.60  ? 35  ASN A O   1 
ATOM   255  C CB  . ASN A 1 35  ? -24.965 -9.582  -8.812  1.00 19.22  ? 35  ASN A CB  1 
ATOM   256  C CG  . ASN A 1 35  ? -24.224 -9.303  -10.102 1.00 18.45  ? 35  ASN A CG  1 
ATOM   257  O OD1 . ASN A 1 35  ? -23.601 -10.201 -10.666 1.00 17.26  ? 35  ASN A OD1 1 
ATOM   258  N ND2 . ASN A 1 35  ? -24.318 -8.075  -10.600 1.00 18.20  ? 35  ASN A ND2 1 
ATOM   259  N N   . TRP A 1 36  ? -26.978 -11.421 -7.174  1.00 22.02  ? 36  TRP A N   1 
ATOM   260  C CA  . TRP A 1 36  ? -27.409 -11.800 -5.844  1.00 24.79  ? 36  TRP A CA  1 
ATOM   261  C C   . TRP A 1 36  ? -26.182 -12.139 -4.998  1.00 25.43  ? 36  TRP A C   1 
ATOM   262  O O   . TRP A 1 36  ? -25.230 -12.753 -5.486  1.00 21.68  ? 36  TRP A O   1 
ATOM   263  C CB  . TRP A 1 36  ? -28.387 -12.971 -5.928  1.00 26.02  ? 36  TRP A CB  1 
ATOM   264  C CG  . TRP A 1 36  ? -29.692 -12.601 -6.553  1.00 30.39  ? 36  TRP A CG  1 
ATOM   265  C CD1 . TRP A 1 36  ? -30.079 -12.835 -7.842  1.00 31.82  ? 36  TRP A CD1 1 
ATOM   266  C CD2 . TRP A 1 36  ? -30.797 -11.926 -5.914  1.00 32.50  ? 36  TRP A CD2 1 
ATOM   267  N NE1 . TRP A 1 36  ? -31.337 -12.330 -8.051  1.00 31.67  ? 36  TRP A NE1 1 
ATOM   268  C CE2 . TRP A 1 36  ? -31.814 -11.795 -6.880  1.00 33.61  ? 36  TRP A CE2 1 
ATOM   269  C CE3 . TRP A 1 36  ? -31.035 -11.433 -4.626  1.00 35.96  ? 36  TRP A CE3 1 
ATOM   270  C CZ2 . TRP A 1 36  ? -33.034 -11.169 -6.596  1.00 36.96  ? 36  TRP A CZ2 1 
ATOM   271  C CZ3 . TRP A 1 36  ? -32.234 -10.810 -4.352  1.00 36.05  ? 36  TRP A CZ3 1 
ATOM   272  C CH2 . TRP A 1 36  ? -33.220 -10.674 -5.326  1.00 34.68  ? 36  TRP A CH2 1 
ATOM   273  N N   . VAL A 1 37  ? -26.232 -11.719 -3.731  1.00 24.92  ? 37  VAL A N   1 
ATOM   274  C CA  . VAL A 1 37  ? -25.104 -11.816 -2.827  1.00 25.38  ? 37  VAL A CA  1 
ATOM   275  C C   . VAL A 1 37  ? -25.642 -12.179 -1.452  1.00 26.91  ? 37  VAL A C   1 
ATOM   276  O O   . VAL A 1 37  ? -26.630 -11.608 -1.002  1.00 30.39  ? 37  VAL A O   1 
ATOM   277  C CB  . VAL A 1 37  ? -24.314 -10.495 -2.779  1.00 26.20  ? 37  VAL A CB  1 
ATOM   278  C CG1 . VAL A 1 37  ? -23.182 -10.534 -1.774  1.00 26.79  ? 37  VAL A CG1 1 
ATOM   279  C CG2 . VAL A 1 37  ? -23.767 -10.099 -4.133  1.00 26.55  ? 37  VAL A CG2 1 
ATOM   280  N N   . ARG A 1 38  ? -24.938 -13.106 -0.799  1.00 29.62  ? 38  ARG A N   1 
ATOM   281  C CA  . ARG A 1 38  ? -25.342 -13.714 0.454   1.00 31.37  ? 38  ARG A CA  1 
ATOM   282  C C   . ARG A 1 38  ? -24.309 -13.356 1.520   1.00 33.56  ? 38  ARG A C   1 
ATOM   283  O O   . ARG A 1 38  ? -23.105 -13.495 1.275   1.00 36.38  ? 38  ARG A O   1 
ATOM   284  C CB  . ARG A 1 38  ? -25.404 -15.238 0.311   1.00 30.71  ? 38  ARG A CB  1 
ATOM   285  C CG  . ARG A 1 38  ? -25.802 -15.964 1.588   1.00 35.86  ? 38  ARG A CG  1 
ATOM   286  C CD  . ARG A 1 38  ? -24.909 -17.138 1.925   1.00 40.19  ? 38  ARG A CD  1 
ATOM   287  N NE  . ARG A 1 38  ? -25.493 -18.401 1.533   1.00 47.99  ? 38  ARG A NE  1 
ATOM   288  C CZ  . ARG A 1 38  ? -24.864 -19.569 1.598   1.00 54.73  ? 38  ARG A CZ  1 
ATOM   289  N NH1 . ARG A 1 38  ? -23.550 -19.616 1.749   1.00 55.86  ? 38  ARG A NH1 1 
ATOM   290  N NH2 . ARG A 1 38  ? -25.554 -20.689 1.460   1.00 58.71  ? 38  ARG A NH2 1 
ATOM   291  N N   . GLN A 1 39  ? -24.808 -12.940 2.695   1.00 28.38  ? 39  GLN A N   1 
ATOM   292  C CA  . GLN A 1 39  ? -23.968 -12.663 3.844   1.00 29.59  ? 39  GLN A CA  1 
ATOM   293  C C   . GLN A 1 39  ? -24.545 -13.343 5.082   1.00 31.69  ? 39  GLN A C   1 
ATOM   294  O O   . GLN A 1 39  ? -25.554 -12.904 5.631   1.00 33.65  ? 39  GLN A O   1 
ATOM   295  C CB  . GLN A 1 39  ? -23.870 -11.159 4.048   1.00 26.32  ? 39  GLN A CB  1 
ATOM   296  C CG  . GLN A 1 39  ? -22.902 -10.792 5.143   1.00 25.50  ? 39  GLN A CG  1 
ATOM   297  C CD  . GLN A 1 39  ? -22.431 -9.380  4.967   1.00 24.16  ? 39  GLN A CD  1 
ATOM   298  O OE1 . GLN A 1 39  ? -23.228 -8.461  4.782   1.00 25.27  ? 39  GLN A OE1 1 
ATOM   299  N NE2 . GLN A 1 39  ? -21.121 -9.207  4.985   1.00 23.58  ? 39  GLN A NE2 1 
ATOM   300  N N   . ALA A 1 40  ? -23.917 -14.445 5.485   1.00 34.09  ? 40  ALA A N   1 
ATOM   301  C CA  . ALA A 1 40  ? -24.316 -15.155 6.686   1.00 38.53  ? 40  ALA A CA  1 
ATOM   302  C C   . ALA A 1 40  ? -23.834 -14.344 7.885   1.00 41.04  ? 40  ALA A C   1 
ATOM   303  O O   . ALA A 1 40  ? -22.790 -13.695 7.781   1.00 35.13  ? 40  ALA A O   1 
ATOM   304  C CB  . ALA A 1 40  ? -23.763 -16.563 6.674   1.00 40.87  ? 40  ALA A CB  1 
ATOM   305  N N   . PRO A 1 41  ? -24.575 -14.336 9.028   1.00 38.47  ? 41  PRO A N   1 
ATOM   306  C CA  . PRO A 1 41  ? -24.306 -13.393 10.114  1.00 37.88  ? 41  PRO A CA  1 
ATOM   307  C C   . PRO A 1 41  ? -22.855 -13.491 10.566  1.00 34.46  ? 41  PRO A C   1 
ATOM   308  O O   . PRO A 1 41  ? -22.337 -14.593 10.755  1.00 30.86  ? 41  PRO A O   1 
ATOM   309  C CB  . PRO A 1 41  ? -25.265 -13.787 11.250  1.00 38.15  ? 41  PRO A CB  1 
ATOM   310  C CG  . PRO A 1 41  ? -25.724 -15.197 10.889  1.00 39.42  ? 41  PRO A CG  1 
ATOM   311  C CD  . PRO A 1 41  ? -25.644 -15.285 9.377   1.00 39.23  ? 41  PRO A CD  1 
ATOM   312  N N   . GLY A 1 42  ? -22.222 -12.313 10.652  1.00 33.14  ? 42  GLY A N   1 
ATOM   313  C CA  . GLY A 1 42  ? -20.825 -12.173 11.015  1.00 37.82  ? 42  GLY A CA  1 
ATOM   314  C C   . GLY A 1 42  ? -19.826 -12.550 9.917   1.00 40.67  ? 42  GLY A C   1 
ATOM   315  O O   . GLY A 1 42  ? -18.626 -12.460 10.165  1.00 40.32  ? 42  GLY A O   1 
ATOM   316  N N   . GLN A 1 43  ? -20.300 -12.932 8.716   1.00 41.31  ? 43  GLN A N   1 
ATOM   317  C CA  . GLN A 1 43  ? -19.447 -13.539 7.700   1.00 42.56  ? 43  GLN A CA  1 
ATOM   318  C C   . GLN A 1 43  ? -19.202 -12.572 6.542   1.00 37.48  ? 43  GLN A C   1 
ATOM   319  O O   . GLN A 1 43  ? -19.681 -11.454 6.577   1.00 33.26  ? 43  GLN A O   1 
ATOM   320  C CB  . GLN A 1 43  ? -20.080 -14.815 7.156   1.00 43.33  ? 43  GLN A CB  1 
ATOM   321  C CG  . GLN A 1 43  ? -19.160 -16.007 7.292   1.00 52.32  ? 43  GLN A CG  1 
ATOM   322  C CD  . GLN A 1 43  ? -19.063 -16.372 8.749   1.00 51.38  ? 43  GLN A CD  1 
ATOM   323  O OE1 . GLN A 1 43  ? -20.049 -16.758 9.366   1.00 56.91  ? 43  GLN A OE1 1 
ATOM   324  N NE2 . GLN A 1 43  ? -17.886 -16.205 9.322   1.00 53.99  ? 43  GLN A NE2 1 
ATOM   325  N N   . GLY A 1 44  ? -18.438 -13.019 5.531   1.00 33.35  ? 44  GLY A N   1 
ATOM   326  C CA  . GLY A 1 44  ? -18.114 -12.192 4.381   1.00 30.20  ? 44  GLY A CA  1 
ATOM   327  C C   . GLY A 1 44  ? -19.195 -12.215 3.293   1.00 27.27  ? 44  GLY A C   1 
ATOM   328  O O   . GLY A 1 44  ? -20.066 -13.078 3.265   1.00 24.92  ? 44  GLY A O   1 
ATOM   329  N N   . LEU A 1 45  ? -19.109 -11.246 2.376   1.00 26.85  ? 45  LEU A N   1 
ATOM   330  C CA  . LEU A 1 45  ? -19.927 -11.221 1.165   1.00 25.76  ? 45  LEU A CA  1 
ATOM   331  C C   . LEU A 1 45  ? -19.580 -12.369 0.225   1.00 23.48  ? 45  LEU A C   1 
ATOM   332  O O   . LEU A 1 45  ? -18.433 -12.698 0.034   1.00 27.01  ? 45  LEU A O   1 
ATOM   333  C CB  . LEU A 1 45  ? -19.707 -9.890  0.451   1.00 23.70  ? 45  LEU A CB  1 
ATOM   334  C CG  . LEU A 1 45  ? -20.115 -8.668  1.263   1.00 24.45  ? 45  LEU A CG  1 
ATOM   335  C CD1 . LEU A 1 45  ? -19.706 -7.397  0.532   1.00 22.94  ? 45  LEU A CD1 1 
ATOM   336  C CD2 . LEU A 1 45  ? -21.616 -8.705  1.554   1.00 23.48  ? 45  LEU A CD2 1 
ATOM   337  N N   . GLU A 1 46  ? -20.594 -12.968 -0.385  1.00 26.47  ? 46  GLU A N   1 
ATOM   338  C CA  . GLU A 1 46  ? -20.400 -14.118 -1.246  1.00 28.78  ? 46  GLU A CA  1 
ATOM   339  C C   . GLU A 1 46  ? -21.333 -13.995 -2.446  1.00 29.17  ? 46  GLU A C   1 
ATOM   340  O O   . GLU A 1 46  ? -22.561 -13.914 -2.278  1.00 25.72  ? 46  GLU A O   1 
ATOM   341  C CB  . GLU A 1 46  ? -20.676 -15.374 -0.426  1.00 34.48  ? 46  GLU A CB  1 
ATOM   342  C CG  . GLU A 1 46  ? -20.259 -16.652 -1.113  1.00 43.55  ? 46  GLU A CG  1 
ATOM   343  C CD  . GLU A 1 46  ? -20.545 -17.923 -0.322  1.00 53.16  ? 46  GLU A CD  1 
ATOM   344  O OE1 . GLU A 1 46  ? -20.286 -19.015 -0.898  1.00 49.05  ? 46  GLU A OE1 1 
ATOM   345  O OE2 . GLU A 1 46  ? -21.028 -17.821 0.865   1.00 50.02  ? 46  GLU A OE2 1 
ATOM   346  N N   . TRP A 1 47  ? -20.740 -13.964 -3.648  1.00 26.37  ? 47  TRP A N   1 
ATOM   347  C CA  . TRP A 1 47  ? -21.511 -13.831 -4.877  1.00 23.91  ? 47  TRP A CA  1 
ATOM   348  C C   . TRP A 1 47  ? -22.301 -15.105 -5.147  1.00 22.31  ? 47  TRP A C   1 
ATOM   349  O O   . TRP A 1 47  ? -21.742 -16.189 -5.091  1.00 22.67  ? 47  TRP A O   1 
ATOM   350  C CB  . TRP A 1 47  ? -20.569 -13.527 -6.044  1.00 22.10  ? 47  TRP A CB  1 
ATOM   351  C CG  . TRP A 1 47  ? -21.261 -13.307 -7.353  1.00 21.13  ? 47  TRP A CG  1 
ATOM   352  C CD1 . TRP A 1 47  ? -22.029 -12.239 -7.722  1.00 21.20  ? 47  TRP A CD1 1 
ATOM   353  C CD2 . TRP A 1 47  ? -21.203 -14.178 -8.491  1.00 21.55  ? 47  TRP A CD2 1 
ATOM   354  N NE1 . TRP A 1 47  ? -22.445 -12.386 -9.019  1.00 22.39  ? 47  TRP A NE1 1 
ATOM   355  C CE2 . TRP A 1 47  ? -21.957 -13.570 -9.516  1.00 20.54  ? 47  TRP A CE2 1 
ATOM   356  C CE3 . TRP A 1 47  ? -20.564 -15.399 -8.749  1.00 22.46  ? 47  TRP A CE3 1 
ATOM   357  C CZ2 . TRP A 1 47  ? -22.109 -14.154 -10.776 1.00 20.38  ? 47  TRP A CZ2 1 
ATOM   358  C CZ3 . TRP A 1 47  ? -20.712 -15.972 -9.996  1.00 21.86  ? 47  TRP A CZ3 1 
ATOM   359  C CH2 . TRP A 1 47  ? -21.483 -15.361 -10.991 1.00 19.97  ? 47  TRP A CH2 1 
ATOM   360  N N   . MET A 1 48  ? -23.594 -14.978 -5.440  1.00 22.12  ? 48  MET A N   1 
ATOM   361  C CA  . MET A 1 48  ? -24.420 -16.166 -5.662  1.00 23.53  ? 48  MET A CA  1 
ATOM   362  C C   . MET A 1 48  ? -24.626 -16.420 -7.160  1.00 22.26  ? 48  MET A C   1 
ATOM   363  O O   . MET A 1 48  ? -24.838 -17.544 -7.574  1.00 23.63  ? 48  MET A O   1 
ATOM   364  C CB  . MET A 1 48  ? -25.794 -16.019 -5.006  1.00 21.82  ? 48  MET A CB  1 
ATOM   365  C CG  . MET A 1 48  ? -25.777 -16.067 -3.482  1.00 24.26  ? 48  MET A CG  1 
ATOM   366  S SD  . MET A 1 48  ? -27.357 -15.435 -2.802  1.00 26.21  ? 48  MET A SD  1 
ATOM   367  C CE  . MET A 1 48  ? -28.389 -16.865 -3.114  1.00 25.89  ? 48  MET A CE  1 
ATOM   368  N N   . GLY A 1 49  ? -24.587 -15.370 -7.979  1.00 22.14  ? 49  GLY A N   1 
ATOM   369  C CA  . GLY A 1 49  ? -24.853 -15.508 -9.397  1.00 21.68  ? 49  GLY A CA  1 
ATOM   370  C C   . GLY A 1 49  ? -25.465 -14.237 -9.964  1.00 23.32  ? 49  GLY A C   1 
ATOM   371  O O   . GLY A 1 49  ? -25.612 -13.227 -9.264  1.00 22.13  ? 49  GLY A O   1 
ATOM   372  N N   . TRP A 1 50  ? -25.810 -14.325 -11.249 1.00 23.50  ? 50  TRP A N   1 
ATOM   373  C CA  . TRP A 1 50  ? -26.178 -13.178 -12.057 1.00 23.62  ? 50  TRP A CA  1 
ATOM   374  C C   . TRP A 1 50  ? -27.360 -13.561 -12.937 1.00 23.68  ? 50  TRP A C   1 
ATOM   375  O O   . TRP A 1 50  ? -27.475 -14.709 -13.347 1.00 25.56  ? 50  TRP A O   1 
ATOM   376  C CB  . TRP A 1 50  ? -24.946 -12.772 -12.873 1.00 24.41  ? 50  TRP A CB  1 
ATOM   377  C CG  . TRP A 1 50  ? -25.135 -11.763 -13.960 1.00 24.21  ? 50  TRP A CG  1 
ATOM   378  C CD1 . TRP A 1 50  ? -24.960 -10.419 -13.845 1.00 24.74  ? 50  TRP A CD1 1 
ATOM   379  C CD2 . TRP A 1 50  ? -25.373 -12.015 -15.357 1.00 23.67  ? 50  TRP A CD2 1 
ATOM   380  N NE1 . TRP A 1 50  ? -25.129 -9.818  -15.063 1.00 25.68  ? 50  TRP A NE1 1 
ATOM   381  C CE2 . TRP A 1 50  ? -25.363 -10.770 -16.013 1.00 24.44  ? 50  TRP A CE2 1 
ATOM   382  C CE3 . TRP A 1 50  ? -25.564 -13.164 -16.125 1.00 26.27  ? 50  TRP A CE3 1 
ATOM   383  C CZ2 . TRP A 1 50  ? -25.556 -10.635 -17.391 1.00 24.95  ? 50  TRP A CZ2 1 
ATOM   384  C CZ3 . TRP A 1 50  ? -25.758 -13.041 -17.485 1.00 27.04  ? 50  TRP A CZ3 1 
ATOM   385  C CH2 . TRP A 1 50  ? -25.758 -11.791 -18.106 1.00 25.49  ? 50  TRP A CH2 1 
ATOM   386  N N   . ILE A 1 51  ? -28.232 -12.600 -13.226 1.00 21.85  ? 51  ILE A N   1 
ATOM   387  C CA  . ILE A 1 51  ? -29.280 -12.842 -14.189 1.00 22.68  ? 51  ILE A CA  1 
ATOM   388  C C   . ILE A 1 51  ? -29.248 -11.744 -15.242 1.00 21.64  ? 51  ILE A C   1 
ATOM   389  O O   . ILE A 1 51  ? -29.257 -10.562 -14.910 1.00 22.87  ? 51  ILE A O   1 
ATOM   390  C CB  . ILE A 1 51  ? -30.669 -12.966 -13.525 1.00 25.93  ? 51  ILE A CB  1 
ATOM   391  C CG1 . ILE A 1 51  ? -31.700 -13.486 -14.534 1.00 27.83  ? 51  ILE A CG1 1 
ATOM   392  C CG2 . ILE A 1 51  ? -31.122 -11.658 -12.871 1.00 24.86  ? 51  ILE A CG2 1 
ATOM   393  C CD1 . ILE A 1 51  ? -33.079 -13.801 -13.938 1.00 28.32  ? 51  ILE A CD1 1 
ATOM   394  N N   . ASN A 1 52  ? -29.234 -12.180 -16.513 1.00 21.61  ? 52  ASN A N   1 
ATOM   395  C CA  . ASN A 1 52  ? -29.493 -11.351 -17.676 1.00 21.29  ? 52  ASN A CA  1 
ATOM   396  C C   . ASN A 1 52  ? -30.940 -10.847 -17.668 1.00 21.26  ? 52  ASN A C   1 
ATOM   397  O O   . ASN A 1 52  ? -31.881 -11.611 -17.878 1.00 23.85  ? 52  ASN A O   1 
ATOM   398  C CB  . ASN A 1 52  ? -29.231 -12.175 -18.935 1.00 22.79  ? 52  ASN A CB  1 
ATOM   399  C CG  . ASN A 1 52  ? -29.256 -11.354 -20.195 1.00 21.99  ? 52  ASN A CG  1 
ATOM   400  O OD1 . ASN A 1 52  ? -30.018 -10.390 -20.303 1.00 24.55  ? 52  ASN A OD1 1 
ATOM   401  N ND2 . ASN A 1 52  ? -28.372 -11.697 -21.109 1.00 21.70  ? 52  ASN A ND2 1 
ATOM   402  N N   . THR A 1 53  ? -31.137 -9.554  -17.448 1.00 19.96  ? 53  THR A N   1 
ATOM   403  C CA  . THR A 1 53  ? -32.483 -9.046  -17.269 1.00 22.99  ? 53  THR A CA  1 
ATOM   404  C C   . THR A 1 53  ? -33.230 -8.860  -18.585 1.00 27.58  ? 53  THR A C   1 
ATOM   405  O O   . THR A 1 53  ? -34.363 -8.424  -18.550 1.00 29.21  ? 53  THR A O   1 
ATOM   406  C CB  . THR A 1 53  ? -32.455 -7.740  -16.486 1.00 22.05  ? 53  THR A CB  1 
ATOM   407  O OG1 . THR A 1 53  ? -31.381 -6.950  -16.986 1.00 20.00  ? 53  THR A OG1 1 
ATOM   408  C CG2 . THR A 1 53  ? -32.278 -7.991  -15.009 1.00 23.64  ? 53  THR A CG2 1 
ATOM   409  N N   . TYR A 1 54  ? -32.579 -9.118  -19.733 1.00 31.35  ? 54  TYR A N   1 
ATOM   410  C CA  . TYR A 1 54  ? -33.238 -9.052  -21.020 1.00 29.46  ? 54  TYR A CA  1 
ATOM   411  C C   . TYR A 1 54  ? -33.724 -10.447 -21.412 1.00 29.04  ? 54  TYR A C   1 
ATOM   412  O O   . TYR A 1 54  ? -34.864 -10.591 -21.833 1.00 28.88  ? 54  TYR A O   1 
ATOM   413  C CB  . TYR A 1 54  ? -32.316 -8.447  -22.092 1.00 33.61  ? 54  TYR A CB  1 
ATOM   414  C CG  . TYR A 1 54  ? -33.057 -8.055  -23.354 1.00 35.24  ? 54  TYR A CG  1 
ATOM   415  C CD1 . TYR A 1 54  ? -33.443 -8.996  -24.300 1.00 34.68  ? 54  TYR A CD1 1 
ATOM   416  C CD2 . TYR A 1 54  ? -33.428 -6.733  -23.568 1.00 33.59  ? 54  TYR A CD2 1 
ATOM   417  C CE1 . TYR A 1 54  ? -34.177 -8.630  -25.425 1.00 36.22  ? 54  TYR A CE1 1 
ATOM   418  C CE2 . TYR A 1 54  ? -34.133 -6.351  -24.693 1.00 35.54  ? 54  TYR A CE2 1 
ATOM   419  C CZ  . TYR A 1 54  ? -34.529 -7.303  -25.612 1.00 35.48  ? 54  TYR A CZ  1 
ATOM   420  O OH  . TYR A 1 54  ? -35.228 -6.849  -26.698 1.00 46.28  ? 54  TYR A OH  1 
ATOM   421  N N   . THR A 1 55  ? -32.860 -11.465 -21.281 1.00 28.25  ? 55  THR A N   1 
ATOM   422  C CA  . THR A 1 55  ? -33.176 -12.812 -21.732 1.00 30.90  ? 55  THR A CA  1 
ATOM   423  C C   . THR A 1 55  ? -33.818 -13.654 -20.625 1.00 30.87  ? 55  THR A C   1 
ATOM   424  O O   . THR A 1 55  ? -34.443 -14.661 -20.922 1.00 32.49  ? 55  THR A O   1 
ATOM   425  C CB  . THR A 1 55  ? -31.931 -13.560 -22.238 1.00 29.62  ? 55  THR A CB  1 
ATOM   426  O OG1 . THR A 1 55  ? -31.052 -13.767 -21.134 1.00 33.25  ? 55  THR A OG1 1 
ATOM   427  C CG2 . THR A 1 55  ? -31.197 -12.842 -23.347 1.00 30.65  ? 55  THR A CG2 1 
ATOM   428  N N   . GLY A 1 56  ? -33.607 -13.296 -19.352 1.00 30.11  ? 56  GLY A N   1 
ATOM   429  C CA  . GLY A 1 56  ? -34.017 -14.150 -18.246 1.00 31.19  ? 56  GLY A CA  1 
ATOM   430  C C   . GLY A 1 56  ? -33.024 -15.267 -17.902 1.00 30.87  ? 56  GLY A C   1 
ATOM   431  O O   . GLY A 1 56  ? -33.288 -15.999 -16.968 1.00 33.75  ? 56  GLY A O   1 
ATOM   432  N N   . GLN A 1 57  ? -31.915 -15.408 -18.649 1.00 34.24  ? 57  GLN A N   1 
ATOM   433  C CA  . GLN A 1 57  ? -30.919 -16.463 -18.456 1.00 37.82  ? 57  GLN A CA  1 
ATOM   434  C C   . GLN A 1 57  ? -30.136 -16.218 -17.163 1.00 36.60  ? 57  GLN A C   1 
ATOM   435  O O   . GLN A 1 57  ? -29.561 -15.143 -16.973 1.00 31.50  ? 57  GLN A O   1 
ATOM   436  C CB  . GLN A 1 57  ? -29.969 -16.544 -19.659 1.00 44.08  ? 57  GLN A CB  1 
ATOM   437  C CG  . GLN A 1 57  ? -28.495 -16.812 -19.331 1.00 49.62  ? 57  GLN A CG  1 
ATOM   438  C CD  . GLN A 1 57  ? -28.039 -18.214 -19.660 1.00 54.50  ? 57  GLN A CD  1 
ATOM   439  O OE1 . GLN A 1 57  ? -27.448 -18.457 -20.707 1.00 57.97  ? 57  GLN A OE1 1 
ATOM   440  N NE2 . GLN A 1 57  ? -28.327 -19.161 -18.781 1.00 58.04  ? 57  GLN A NE2 1 
ATOM   441  N N   . PRO A 1 58  ? -30.160 -17.184 -16.218 1.00 35.20  ? 58  PRO A N   1 
ATOM   442  C CA  . PRO A 1 58  ? -29.476 -17.056 -14.938 1.00 34.16  ? 58  PRO A CA  1 
ATOM   443  C C   . PRO A 1 58  ? -28.147 -17.795 -14.953 1.00 31.56  ? 58  PRO A C   1 
ATOM   444  O O   . PRO A 1 58  ? -28.062 -18.852 -15.562 1.00 32.73  ? 58  PRO A O   1 
ATOM   445  C CB  . PRO A 1 58  ? -30.506 -17.702 -13.993 1.00 35.37  ? 58  PRO A CB  1 
ATOM   446  C CG  . PRO A 1 58  ? -31.151 -18.804 -14.804 1.00 39.02  ? 58  PRO A CG  1 
ATOM   447  C CD  . PRO A 1 58  ? -30.985 -18.403 -16.261 1.00 40.88  ? 58  PRO A CD  1 
ATOM   448  N N   . ILE A 1 59  ? -27.122 -17.220 -14.312 1.00 32.01  ? 59  ILE A N   1 
ATOM   449  C CA  . ILE A 1 59  ? -25.825 -17.867 -14.146 1.00 32.49  ? 59  ILE A CA  1 
ATOM   450  C C   . ILE A 1 59  ? -25.591 -18.021 -12.645 1.00 30.83  ? 59  ILE A C   1 
ATOM   451  O O   . ILE A 1 59  ? -25.661 -17.020 -11.934 1.00 28.65  ? 59  ILE A O   1 
ATOM   452  C CB  . ILE A 1 59  ? -24.679 -17.033 -14.767 1.00 35.23  ? 59  ILE A CB  1 
ATOM   453  C CG1 . ILE A 1 59  ? -24.976 -16.531 -16.180 1.00 37.06  ? 59  ILE A CG1 1 
ATOM   454  C CG2 . ILE A 1 59  ? -23.363 -17.798 -14.723 1.00 33.29  ? 59  ILE A CG2 1 
ATOM   455  C CD1 . ILE A 1 59  ? -24.590 -17.481 -17.273 1.00 36.85  ? 59  ILE A CD1 1 
ATOM   456  N N   . TYR A 1 60  ? -25.268 -19.248 -12.200 1.00 30.76  ? 60  TYR A N   1 
ATOM   457  C CA  . TYR A 1 60  ? -25.109 -19.595 -10.790 1.00 31.14  ? 60  TYR A CA  1 
ATOM   458  C C   . TYR A 1 60  ? -23.645 -19.874 -10.458 1.00 28.86  ? 60  TYR A C   1 
ATOM   459  O O   . TYR A 1 60  ? -22.972 -20.611 -11.172 1.00 29.84  ? 60  TYR A O   1 
ATOM   460  C CB  . TYR A 1 60  ? -25.942 -20.838 -10.435 1.00 32.06  ? 60  TYR A CB  1 
ATOM   461  C CG  . TYR A 1 60  ? -27.409 -20.625 -10.646 1.00 30.16  ? 60  TYR A CG  1 
ATOM   462  C CD1 . TYR A 1 60  ? -28.129 -19.762 -9.836  1.00 29.14  ? 60  TYR A CD1 1 
ATOM   463  C CD2 . TYR A 1 60  ? -28.056 -21.207 -11.720 1.00 32.64  ? 60  TYR A CD2 1 
ATOM   464  C CE1 . TYR A 1 60  ? -29.472 -19.508 -10.065 1.00 27.22  ? 60  TYR A CE1 1 
ATOM   465  C CE2 . TYR A 1 60  ? -29.403 -20.973 -11.956 1.00 32.01  ? 60  TYR A CE2 1 
ATOM   466  C CZ  . TYR A 1 60  ? -30.108 -20.109 -11.133 1.00 27.72  ? 60  TYR A CZ  1 
ATOM   467  O OH  . TYR A 1 60  ? -31.429 -19.873 -11.405 1.00 25.15  ? 60  TYR A OH  1 
ATOM   468  N N   . ALA A 1 61  ? -23.158 -19.286 -9.358  1.00 28.87  ? 61  ALA A N   1 
ATOM   469  C CA  . ALA A 1 61  ? -21.843 -19.623 -8.837  1.00 28.16  ? 61  ALA A CA  1 
ATOM   470  C C   . ALA A 1 61  ? -21.840 -21.093 -8.455  1.00 31.06  ? 61  ALA A C   1 
ATOM   471  O O   . ALA A 1 61  ? -22.899 -21.692 -8.240  1.00 30.83  ? 61  ALA A O   1 
ATOM   472  C CB  . ALA A 1 61  ? -21.490 -18.776 -7.641  1.00 27.19  ? 61  ALA A CB  1 
ATOM   473  N N   . ASN A 1 62  ? -20.634 -21.632 -8.292  1.00 32.89  ? 62  ASN A N   1 
ATOM   474  C CA  . ASN A 1 62  ? -20.469 -23.065 -8.118  1.00 38.65  ? 62  ASN A CA  1 
ATOM   475  C C   . ASN A 1 62  ? -21.224 -23.554 -6.881  1.00 41.71  ? 62  ASN A C   1 
ATOM   476  O O   . ASN A 1 62  ? -21.881 -24.592 -6.933  1.00 43.66  ? 62  ASN A O   1 
ATOM   477  C CB  . ASN A 1 62  ? -18.986 -23.448 -8.115  1.00 41.46  ? 62  ASN A CB  1 
ATOM   478  C CG  . ASN A 1 62  ? -18.429 -23.519 -9.520  1.00 48.06  ? 62  ASN A CG  1 
ATOM   479  O OD1 . ASN A 1 62  ? -19.042 -24.134 -10.389 1.00 54.85  ? 62  ASN A OD1 1 
ATOM   480  N ND2 . ASN A 1 62  ? -17.293 -22.884 -9.769  1.00 51.43  ? 62  ASN A ND2 1 
ATOM   481  N N   . ASP A 1 63  ? -21.183 -22.757 -5.806  1.00 43.77  ? 63  ASP A N   1 
ATOM   482  C CA  . ASP A 1 63  ? -21.740 -23.142 -4.523  1.00 43.39  ? 63  ASP A CA  1 
ATOM   483  C C   . ASP A 1 63  ? -23.246 -22.933 -4.432  1.00 42.41  ? 63  ASP A C   1 
ATOM   484  O O   . ASP A 1 63  ? -23.791 -23.119 -3.343  1.00 43.04  ? 63  ASP A O   1 
ATOM   485  C CB  . ASP A 1 63  ? -21.086 -22.329 -3.405  1.00 47.04  ? 63  ASP A CB  1 
ATOM   486  C CG  . ASP A 1 63  ? -19.715 -22.853 -3.022  1.00 49.53  ? 63  ASP A CG  1 
ATOM   487  O OD1 . ASP A 1 63  ? -19.416 -24.012 -3.373  1.00 52.63  ? 63  ASP A OD1 1 
ATOM   488  O OD2 . ASP A 1 63  ? -18.955 -22.095 -2.393  1.00 50.97  ? 63  ASP A OD2 1 
ATOM   489  N N   . PHE A 1 64  ? -23.915 -22.522 -5.520  1.00 40.17  ? 64  PHE A N   1 
ATOM   490  C CA  . PHE A 1 64  ? -25.335 -22.209 -5.439  1.00 37.02  ? 64  PHE A CA  1 
ATOM   491  C C   . PHE A 1 64  ? -26.126 -22.763 -6.615  1.00 39.81  ? 64  PHE A C   1 
ATOM   492  O O   . PHE A 1 64  ? -27.006 -22.094 -7.153  1.00 40.99  ? 64  PHE A O   1 
ATOM   493  C CB  . PHE A 1 64  ? -25.552 -20.704 -5.393  1.00 37.10  ? 64  PHE A CB  1 
ATOM   494  C CG  . PHE A 1 64  ? -24.969 -20.067 -4.176  1.00 36.60  ? 64  PHE A CG  1 
ATOM   495  C CD1 . PHE A 1 64  ? -25.697 -20.010 -3.009  1.00 39.91  ? 64  PHE A CD1 1 
ATOM   496  C CD2 . PHE A 1 64  ? -23.693 -19.556 -4.195  1.00 38.36  ? 64  PHE A CD2 1 
ATOM   497  C CE1 . PHE A 1 64  ? -25.155 -19.437 -1.876  1.00 39.48  ? 64  PHE A CE1 1 
ATOM   498  C CE2 . PHE A 1 64  ? -23.148 -18.985 -3.062  1.00 39.65  ? 64  PHE A CE2 1 
ATOM   499  C CZ  . PHE A 1 64  ? -23.884 -18.927 -1.906  1.00 40.12  ? 64  PHE A CZ  1 
ATOM   500  N N   . LYS A 1 65  ? -25.891 -24.021 -6.964  1.00 45.85  ? 65  LYS A N   1 
ATOM   501  C CA  . LYS A 1 65  ? -26.787 -24.677 -7.900  1.00 51.27  ? 65  LYS A CA  1 
ATOM   502  C C   . LYS A 1 65  ? -27.703 -25.571 -7.068  1.00 46.34  ? 65  LYS A C   1 
ATOM   503  O O   . LYS A 1 65  ? -27.579 -25.613 -5.852  1.00 55.27  ? 65  LYS A O   1 
ATOM   504  C CB  . LYS A 1 65  ? -25.971 -25.362 -9.004  1.00 57.54  ? 65  LYS A CB  1 
ATOM   505  C CG  . LYS A 1 65  ? -24.663 -24.654 -9.346  1.00 60.95  ? 65  LYS A CG  1 
ATOM   506  C CD  . LYS A 1 65  ? -24.127 -24.913 -10.740 1.00 63.23  ? 65  LYS A CD  1 
ATOM   507  C CE  . LYS A 1 65  ? -22.614 -24.835 -10.790 1.00 69.91  ? 65  LYS A CE  1 
ATOM   508  N NZ  . LYS A 1 65  ? -22.103 -24.360 -12.100 1.00 66.69  ? 65  LYS A NZ  1 
ATOM   509  N N   . GLY A 1 66  ? -28.661 -26.235 -7.715  1.00 49.47  ? 66  GLY A N   1 
ATOM   510  C CA  . GLY A 1 66  ? -29.655 -27.030 -7.012  1.00 47.77  ? 66  GLY A CA  1 
ATOM   511  C C   . GLY A 1 66  ? -30.782 -26.158 -6.462  1.00 48.67  ? 66  GLY A C   1 
ATOM   512  O O   . GLY A 1 66  ? -31.799 -25.951 -7.115  1.00 52.56  ? 66  GLY A O   1 
ATOM   513  N N   . ARG A 1 67  ? -30.585 -25.590 -5.273  1.00 49.47  ? 67  ARG A N   1 
ATOM   514  C CA  . ARG A 1 67  ? -31.717 -25.096 -4.504  1.00 45.15  ? 67  ARG A CA  1 
ATOM   515  C C   . ARG A 1 67  ? -32.093 -23.658 -4.836  1.00 40.26  ? 67  ARG A C   1 
ATOM   516  O O   . ARG A 1 67  ? -33.051 -23.149 -4.259  1.00 40.42  ? 67  ARG A O   1 
ATOM   517  C CB  . ARG A 1 67  ? -31.412 -25.229 -3.012  1.00 45.17  ? 67  ARG A CB  1 
ATOM   518  C CG  . ARG A 1 67  ? -31.380 -26.674 -2.542  1.00 45.88  ? 67  ARG A CG  1 
ATOM   519  C CD  . ARG A 1 67  ? -31.270 -26.733 -1.037  1.00 46.29  ? 67  ARG A CD  1 
ATOM   520  N NE  . ARG A 1 67  ? -30.054 -26.066 -0.583  1.00 46.72  ? 67  ARG A NE  1 
ATOM   521  C CZ  . ARG A 1 67  ? -30.005 -25.060 0.277   1.00 47.14  ? 67  ARG A CZ  1 
ATOM   522  N NH1 . ARG A 1 67  ? -31.116 -24.482 0.707   1.00 51.07  ? 67  ARG A NH1 1 
ATOM   523  N NH2 . ARG A 1 67  ? -28.830 -24.626 0.694   1.00 46.09  ? 67  ARG A NH2 1 
ATOM   524  N N   . PHE A 1 68  ? -31.346 -23.007 -5.740  1.00 40.00  ? 68  PHE A N   1 
ATOM   525  C CA  . PHE A 1 68  ? -31.470 -21.567 -5.941  1.00 35.70  ? 68  PHE A CA  1 
ATOM   526  C C   . PHE A 1 68  ? -31.890 -21.280 -7.380  1.00 33.38  ? 68  PHE A C   1 
ATOM   527  O O   . PHE A 1 68  ? -31.293 -21.809 -8.308  1.00 32.50  ? 68  PHE A O   1 
ATOM   528  C CB  . PHE A 1 68  ? -30.157 -20.848 -5.594  1.00 34.74  ? 68  PHE A CB  1 
ATOM   529  C CG  . PHE A 1 68  ? -29.619 -21.108 -4.210  1.00 35.25  ? 68  PHE A CG  1 
ATOM   530  C CD1 . PHE A 1 68  ? -29.018 -22.319 -3.892  1.00 40.62  ? 68  PHE A CD1 1 
ATOM   531  C CD2 . PHE A 1 68  ? -29.714 -20.139 -3.223  1.00 37.86  ? 68  PHE A CD2 1 
ATOM   532  C CE1 . PHE A 1 68  ? -28.532 -22.567 -2.614  1.00 39.96  ? 68  PHE A CE1 1 
ATOM   533  C CE2 . PHE A 1 68  ? -29.232 -20.380 -1.948  1.00 39.00  ? 68  PHE A CE2 1 
ATOM   534  C CZ  . PHE A 1 68  ? -28.636 -21.594 -1.644  1.00 42.85  ? 68  PHE A CZ  1 
ATOM   535  N N   . VAL A 1 69  ? -32.891 -20.404 -7.540  1.00 33.63  ? 69  VAL A N   1 
ATOM   536  C CA  . VAL A 1 69  ? -33.457 -20.043 -8.829  1.00 33.53  ? 69  VAL A CA  1 
ATOM   537  C C   . VAL A 1 69  ? -33.578 -18.523 -8.882  1.00 32.87  ? 69  VAL A C   1 
ATOM   538  O O   . VAL A 1 69  ? -34.164 -17.927 -7.989  1.00 34.35  ? 69  VAL A O   1 
ATOM   539  C CB  . VAL A 1 69  ? -34.852 -20.689 -9.024  1.00 35.71  ? 69  VAL A CB  1 
ATOM   540  C CG1 . VAL A 1 69  ? -35.534 -20.226 -10.302 1.00 31.79  ? 69  VAL A CG1 1 
ATOM   541  C CG2 . VAL A 1 69  ? -34.807 -22.210 -8.967  1.00 34.59  ? 69  VAL A CG2 1 
ATOM   542  N N   . PHE A 1 70  ? -33.055 -17.909 -9.948  1.00 34.82  ? 70  PHE A N   1 
ATOM   543  C CA  . PHE A 1 70  ? -33.258 -16.489 -10.198 1.00 32.71  ? 70  PHE A CA  1 
ATOM   544  C C   . PHE A 1 70  ? -34.322 -16.332 -11.275 1.00 28.71  ? 70  PHE A C   1 
ATOM   545  O O   . PHE A 1 70  ? -34.261 -17.025 -12.277 1.00 29.49  ? 70  PHE A O   1 
ATOM   546  C CB  . PHE A 1 70  ? -31.968 -15.805 -10.692 1.00 32.73  ? 70  PHE A CB  1 
ATOM   547  C CG  . PHE A 1 70  ? -30.727 -16.037 -9.858  1.00 32.97  ? 70  PHE A CG  1 
ATOM   548  C CD1 . PHE A 1 70  ? -30.784 -16.113 -8.473  1.00 36.33  ? 70  PHE A CD1 1 
ATOM   549  C CD2 . PHE A 1 70  ? -29.491 -16.167 -10.464 1.00 34.34  ? 70  PHE A CD2 1 
ATOM   550  C CE1 . PHE A 1 70  ? -29.635 -16.318 -7.724  1.00 36.70  ? 70  PHE A CE1 1 
ATOM   551  C CE2 . PHE A 1 70  ? -28.349 -16.392 -9.717  1.00 32.67  ? 70  PHE A CE2 1 
ATOM   552  C CZ  . PHE A 1 70  ? -28.420 -16.461 -8.351  1.00 33.49  ? 70  PHE A CZ  1 
ATOM   553  N N   . SER A 1 71  ? -35.234 -15.369 -11.105 1.00 29.23  ? 71  SER A N   1 
ATOM   554  C CA  . SER A 1 71  ? -36.260 -15.087 -12.098 1.00 30.91  ? 71  SER A CA  1 
ATOM   555  C C   . SER A 1 71  ? -36.543 -13.586 -12.145 1.00 30.28  ? 71  SER A C   1 
ATOM   556  O O   . SER A 1 71  ? -36.061 -12.831 -11.304 1.00 33.13  ? 71  SER A O   1 
ATOM   557  C CB  . SER A 1 71  ? -37.533 -15.884 -11.808 1.00 30.65  ? 71  SER A CB  1 
ATOM   558  O OG  . SER A 1 71  ? -38.179 -15.376 -10.651 1.00 29.82  ? 71  SER A OG  1 
ATOM   559  N N   . LEU A 1 72  ? -37.334 -13.171 -13.136 1.00 31.17  ? 72  LEU A N   1 
ATOM   560  C CA  . LEU A 1 72  ? -37.686 -11.774 -13.335 1.00 38.35  ? 72  LEU A CA  1 
ATOM   561  C C   . LEU A 1 72  ? -39.195 -11.621 -13.430 1.00 39.80  ? 72  LEU A C   1 
ATOM   562  O O   . LEU A 1 72  ? -39.875 -12.545 -13.853 1.00 37.07  ? 72  LEU A O   1 
ATOM   563  C CB  . LEU A 1 72  ? -37.102 -11.298 -14.666 1.00 40.48  ? 72  LEU A CB  1 
ATOM   564  C CG  . LEU A 1 72  ? -35.599 -11.472 -14.841 1.00 41.05  ? 72  LEU A CG  1 
ATOM   565  C CD1 . LEU A 1 72  ? -35.211 -11.115 -16.264 1.00 41.22  ? 72  LEU A CD1 1 
ATOM   566  C CD2 . LEU A 1 72  ? -34.845 -10.612 -13.835 1.00 40.71  ? 72  LEU A CD2 1 
ATOM   567  N N   . ASP A 1 73  ? -39.679 -10.418 -13.108 1.00 42.69  ? 73  ASP A N   1 
ATOM   568  C CA  . ASP A 1 73  ? -40.943 -9.924  -13.615 1.00 40.38  ? 73  ASP A CA  1 
ATOM   569  C C   . ASP A 1 73  ? -40.682 -8.552  -14.228 1.00 38.97  ? 73  ASP A C   1 
ATOM   570  O O   . ASP A 1 73  ? -40.820 -7.531  -13.559 1.00 38.47  ? 73  ASP A O   1 
ATOM   571  C CB  . ASP A 1 73  ? -42.005 -9.855  -12.517 1.00 48.30  ? 73  ASP A CB  1 
ATOM   572  C CG  . ASP A 1 73  ? -43.408 -9.566  -13.033 1.00 52.14  ? 73  ASP A CG  1 
ATOM   573  O OD1 . ASP A 1 73  ? -43.563 -8.620  -13.843 1.00 52.83  ? 73  ASP A OD1 1 
ATOM   574  O OD2 . ASP A 1 73  ? -44.338 -10.293 -12.620 1.00 53.65  ? 73  ASP A OD2 1 
ATOM   575  N N   . THR A 1 74  ? -40.322 -8.547  -15.517 1.00 37.25  ? 74  THR A N   1 
ATOM   576  C CA  . THR A 1 74  ? -39.928 -7.344  -16.232 1.00 38.59  ? 74  THR A CA  1 
ATOM   577  C C   . THR A 1 74  ? -40.990 -6.256  -16.120 1.00 37.62  ? 74  THR A C   1 
ATOM   578  O O   . THR A 1 74  ? -40.661 -5.079  -16.094 1.00 35.26  ? 74  THR A O   1 
ATOM   579  C CB  . THR A 1 74  ? -39.579 -7.728  -17.674 1.00 45.06  ? 74  THR A CB  1 
ATOM   580  O OG1 . THR A 1 74  ? -38.704 -8.849  -17.540 1.00 52.68  ? 74  THR A OG1 1 
ATOM   581  C CG2 . THR A 1 74  ? -38.902 -6.634  -18.466 1.00 47.99  ? 74  THR A CG2 1 
ATOM   582  N N   . SER A 1 75  ? -42.266 -6.650  -15.978 1.00 45.27  ? 75  SER A N   1 
ATOM   583  C CA  . SER A 1 75  ? -43.374 -5.710  -16.052 1.00 41.64  ? 75  SER A CA  1 
ATOM   584  C C   . SER A 1 75  ? -43.456 -4.825  -14.805 1.00 43.74  ? 75  SER A C   1 
ATOM   585  O O   . SER A 1 75  ? -44.020 -3.732  -14.870 1.00 46.62  ? 75  SER A O   1 
ATOM   586  C CB  . SER A 1 75  ? -44.672 -6.427  -16.363 1.00 42.10  ? 75  SER A CB  1 
ATOM   587  O OG  . SER A 1 75  ? -45.382 -6.776  -15.194 1.00 38.00  ? 75  SER A OG  1 
ATOM   588  N N   . VAL A 1 76  ? -42.835 -5.245  -13.693 1.00 43.27  ? 76  VAL A N   1 
ATOM   589  C CA  . VAL A 1 76  ? -42.667 -4.364  -12.541 1.00 43.86  ? 76  VAL A CA  1 
ATOM   590  C C   . VAL A 1 76  ? -41.181 -4.237  -12.163 1.00 43.06  ? 76  VAL A C   1 
ATOM   591  O O   . VAL A 1 76  ? -40.855 -3.939  -11.016 1.00 38.65  ? 76  VAL A O   1 
ATOM   592  C CB  . VAL A 1 76  ? -43.552 -4.824  -11.358 1.00 46.32  ? 76  VAL A CB  1 
ATOM   593  C CG1 . VAL A 1 76  ? -45.030 -4.542  -11.617 1.00 43.94  ? 76  VAL A CG1 1 
ATOM   594  C CG2 . VAL A 1 76  ? -43.350 -6.294  -10.998 1.00 42.05  ? 76  VAL A CG2 1 
ATOM   595  N N   . SER A 1 77  ? -40.279 -4.447  -13.137 1.00 43.08  ? 77  SER A N   1 
ATOM   596  C CA  . SER A 1 77  ? -38.846 -4.231  -12.963 1.00 36.24  ? 77  SER A CA  1 
ATOM   597  C C   . SER A 1 77  ? -38.322 -4.926  -11.707 1.00 34.51  ? 77  SER A C   1 
ATOM   598  O O   . SER A 1 77  ? -37.677 -4.287  -10.880 1.00 32.44  ? 77  SER A O   1 
ATOM   599  C CB  . SER A 1 77  ? -38.553 -2.761  -12.883 1.00 36.50  ? 77  SER A CB  1 
ATOM   600  O OG  . SER A 1 77  ? -38.874 -2.121  -14.094 1.00 36.84  ? 77  SER A OG  1 
ATOM   601  N N   . THR A 1 78  ? -38.632 -6.211  -11.537 1.00 29.82  ? 78  THR A N   1 
ATOM   602  C CA  . THR A 1 78  ? -38.375 -6.867  -10.272 1.00 31.37  ? 78  THR A CA  1 
ATOM   603  C C   . THR A 1 78  ? -37.582 -8.136  -10.542 1.00 29.64  ? 78  THR A C   1 
ATOM   604  O O   . THR A 1 78  ? -37.884 -8.834  -11.490 1.00 27.83  ? 78  THR A O   1 
ATOM   605  C CB  . THR A 1 78  ? -39.680 -7.111  -9.494  1.00 30.74  ? 78  THR A CB  1 
ATOM   606  O OG1 . THR A 1 78  ? -40.276 -5.856  -9.160  1.00 34.55  ? 78  THR A OG1 1 
ATOM   607  C CG2 . THR A 1 78  ? -39.466 -7.860  -8.203  1.00 33.05  ? 78  THR A CG2 1 
ATOM   608  N N   . ALA A 1 79  ? -36.548 -8.379  -9.725  1.00 29.95  ? 79  ALA A N   1 
ATOM   609  C CA  . ALA A 1 79  ? -35.793 -9.624  -9.774  1.00 31.48  ? 79  ALA A CA  1 
ATOM   610  C C   . ALA A 1 79  ? -36.167 -10.438 -8.544  1.00 29.38  ? 79  ALA A C   1 
ATOM   611  O O   . ALA A 1 79  ? -36.434 -9.860  -7.490  1.00 29.99  ? 79  ALA A O   1 
ATOM   612  C CB  . ALA A 1 79  ? -34.299 -9.352  -9.802  1.00 29.05  ? 79  ALA A CB  1 
ATOM   613  N N   . TYR A 1 80  ? -36.147 -11.764 -8.677  1.00 27.89  ? 80  TYR A N   1 
ATOM   614  C CA  . TYR A 1 80  ? -36.578 -12.629 -7.595  1.00 32.00  ? 80  TYR A CA  1 
ATOM   615  C C   . TYR A 1 80  ? -35.484 -13.649 -7.318  1.00 32.77  ? 80  TYR A C   1 
ATOM   616  O O   . TYR A 1 80  ? -34.866 -14.164 -8.249  1.00 29.23  ? 80  TYR A O   1 
ATOM   617  C CB  . TYR A 1 80  ? -37.883 -13.370 -7.930  1.00 32.31  ? 80  TYR A CB  1 
ATOM   618  C CG  . TYR A 1 80  ? -39.103 -12.492 -8.039  1.00 35.27  ? 80  TYR A CG  1 
ATOM   619  C CD1 . TYR A 1 80  ? -39.769 -12.045 -6.912  1.00 37.18  ? 80  TYR A CD1 1 
ATOM   620  C CD2 . TYR A 1 80  ? -39.616 -12.132 -9.276  1.00 41.42  ? 80  TYR A CD2 1 
ATOM   621  C CE1 . TYR A 1 80  ? -40.893 -11.239 -7.004  1.00 39.48  ? 80  TYR A CE1 1 
ATOM   622  C CE2 . TYR A 1 80  ? -40.746 -11.337 -9.392  1.00 41.95  ? 80  TYR A CE2 1 
ATOM   623  C CZ  . TYR A 1 80  ? -41.379 -10.880 -8.249  1.00 43.16  ? 80  TYR A CZ  1 
ATOM   624  O OH  . TYR A 1 80  ? -42.479 -10.070 -8.337  1.00 47.88  ? 80  TYR A OH  1 
ATOM   625  N N   . LEU A 1 81  ? -35.308 -13.936 -6.021  1.00 34.85  ? 81  LEU A N   1 
ATOM   626  C CA  . LEU A 1 81  ? -34.515 -15.058 -5.560  1.00 35.90  ? 81  LEU A CA  1 
ATOM   627  C C   . LEU A 1 81  ? -35.433 -16.019 -4.809  1.00 39.30  ? 81  LEU A C   1 
ATOM   628  O O   . LEU A 1 81  ? -36.106 -15.620 -3.852  1.00 34.74  ? 81  LEU A O   1 
ATOM   629  C CB  . LEU A 1 81  ? -33.377 -14.548 -4.666  1.00 35.43  ? 81  LEU A CB  1 
ATOM   630  C CG  . LEU A 1 81  ? -32.630 -15.619 -3.874  1.00 34.19  ? 81  LEU A CG  1 
ATOM   631  C CD1 . LEU A 1 81  ? -31.948 -16.612 -4.813  1.00 34.21  ? 81  LEU A CD1 1 
ATOM   632  C CD2 . LEU A 1 81  ? -31.626 -14.984 -2.914  1.00 35.04  ? 81  LEU A CD2 1 
ATOM   633  N N   . GLN A 1 82  ? -35.390 -17.281 -5.264  1.00 41.15  ? 82  GLN A N   1 
ATOM   634  C CA  . GLN A 1 82  ? -36.155 -18.389 -4.728  1.00 44.91  ? 82  GLN A CA  1 
ATOM   635  C C   . GLN A 1 82  ? -35.205 -19.459 -4.200  1.00 42.13  ? 82  GLN A C   1 
ATOM   636  O O   . GLN A 1 82  ? -34.506 -20.111 -4.973  1.00 38.76  ? 82  GLN A O   1 
ATOM   637  C CB  . GLN A 1 82  ? -37.009 -19.007 -5.833  1.00 49.88  ? 82  GLN A CB  1 
ATOM   638  C CG  . GLN A 1 82  ? -37.852 -20.186 -5.366  1.00 62.19  ? 82  GLN A CG  1 
ATOM   639  C CD  . GLN A 1 82  ? -39.274 -19.770 -5.084  1.00 70.31  ? 82  GLN A CD  1 
ATOM   640  O OE1 . GLN A 1 82  ? -39.720 -19.740 -3.937  1.00 83.17  ? 82  GLN A OE1 1 
ATOM   641  N NE2 . GLN A 1 82  ? -39.989 -19.421 -6.143  1.00 66.53  ? 82  GLN A NE2 1 
ATOM   642  N N   . ILE A 1 83  ? -35.219 -19.665 -2.880  1.00 41.30  ? 83  ILE A N   1 
ATOM   643  C CA  . ILE A 1 83  ? -34.471 -20.757 -2.283  1.00 44.78  ? 83  ILE A CA  1 
ATOM   644  C C   . ILE A 1 83  ? -35.466 -21.796 -1.768  1.00 46.32  ? 83  ILE A C   1 
ATOM   645  O O   . ILE A 1 83  ? -36.432 -21.453 -1.080  1.00 46.32  ? 83  ILE A O   1 
ATOM   646  C CB  . ILE A 1 83  ? -33.549 -20.251 -1.160  1.00 40.33  ? 83  ILE A CB  1 
ATOM   647  C CG1 . ILE A 1 83  ? -32.884 -18.925 -1.545  1.00 39.16  ? 83  ILE A CG1 1 
ATOM   648  C CG2 . ILE A 1 83  ? -32.542 -21.330 -0.806  1.00 40.15  ? 83  ILE A CG2 1 
ATOM   649  C CD1 . ILE A 1 83  ? -32.270 -18.161 -0.392  1.00 37.57  ? 83  ILE A CD1 1 
ATOM   650  N N   . SER A 1 84  ? -35.189 -23.065 -2.080  1.00 42.98  ? 84  SER A N   1 
ATOM   651  C CA  . SER A 1 84  ? -36.069 -24.162 -1.714  1.00 47.81  ? 84  SER A CA  1 
ATOM   652  C C   . SER A 1 84  ? -35.352 -25.067 -0.715  1.00 47.13  ? 84  SER A C   1 
ATOM   653  O O   . SER A 1 84  ? -34.135 -24.971 -0.590  1.00 44.36  ? 84  SER A O   1 
ATOM   654  C CB  . SER A 1 84  ? -36.501 -24.911 -2.950  1.00 46.86  ? 84  SER A CB  1 
ATOM   655  O OG  . SER A 1 84  ? -35.405 -25.610 -3.512  1.00 52.51  ? 84  SER A OG  1 
ATOM   656  N N   . SER A 1 85  ? -36.110 -25.929 -0.009  1.00 48.91  ? 85  SER A N   1 
ATOM   657  C CA  . SER A 1 85  ? -35.566 -26.826 1.006   1.00 43.65  ? 85  SER A CA  1 
ATOM   658  C C   . SER A 1 85  ? -34.659 -26.069 1.970   1.00 39.66  ? 85  SER A C   1 
ATOM   659  O O   . SER A 1 85  ? -33.504 -26.444 2.127   1.00 37.86  ? 85  SER A O   1 
ATOM   660  C CB  . SER A 1 85  ? -34.785 -27.958 0.398   1.00 44.66  ? 85  SER A CB  1 
ATOM   661  O OG  . SER A 1 85  ? -35.444 -28.468 -0.739  1.00 50.90  ? 85  SER A OG  1 
ATOM   662  N N   . LEU A 1 86  ? -35.179 -25.013 2.600   1.00 41.76  ? 86  LEU A N   1 
ATOM   663  C CA  . LEU A 1 86  ? -34.384 -24.163 3.478   1.00 45.82  ? 86  LEU A CA  1 
ATOM   664  C C   . LEU A 1 86  ? -33.704 -24.985 4.572   1.00 48.57  ? 86  LEU A C   1 
ATOM   665  O O   . LEU A 1 86  ? -34.331 -25.865 5.164   1.00 54.48  ? 86  LEU A O   1 
ATOM   666  C CB  . LEU A 1 86  ? -35.289 -23.100 4.119   1.00 46.18  ? 86  LEU A CB  1 
ATOM   667  C CG  . LEU A 1 86  ? -35.253 -21.675 3.561   1.00 46.42  ? 86  LEU A CG  1 
ATOM   668  C CD1 . LEU A 1 86  ? -34.055 -21.423 2.644   1.00 43.44  ? 86  LEU A CD1 1 
ATOM   669  C CD2 . LEU A 1 86  ? -36.564 -21.314 2.882   1.00 48.50  ? 86  LEU A CD2 1 
ATOM   670  N N   . LYS A 1 87  ? -32.427 -24.667 4.837   1.00 48.96  ? 87  LYS A N   1 
ATOM   671  C CA  . LYS A 1 87  ? -31.668 -25.185 5.968   1.00 49.10  ? 87  LYS A CA  1 
ATOM   672  C C   . LYS A 1 87  ? -31.325 -24.046 6.925   1.00 51.97  ? 87  LYS A C   1 
ATOM   673  O O   . LYS A 1 87  ? -31.348 -22.878 6.546   1.00 43.26  ? 87  LYS A O   1 
ATOM   674  C CB  . LYS A 1 87  ? -30.299 -25.736 5.565   1.00 52.00  ? 87  LYS A CB  1 
ATOM   675  C CG  . LYS A 1 87  ? -30.278 -26.894 4.584   1.00 58.08  ? 87  LYS A CG  1 
ATOM   676  C CD  . LYS A 1 87  ? -28.875 -27.453 4.487   1.00 63.45  ? 87  LYS A CD  1 
ATOM   677  C CE  . LYS A 1 87  ? -28.731 -28.635 3.557   1.00 71.94  ? 87  LYS A CE  1 
ATOM   678  N NZ  . LYS A 1 87  ? -28.651 -28.221 2.137   1.00 74.51  ? 87  LYS A NZ  1 
ATOM   679  N N   . ALA A 1 88  ? -30.917 -24.399 8.148   1.00 53.43  ? 88  ALA A N   1 
ATOM   680  C CA  . ALA A 1 88  ? -30.574 -23.397 9.146   1.00 55.51  ? 88  ALA A CA  1 
ATOM   681  C C   . ALA A 1 88  ? -29.435 -22.506 8.650   1.00 51.46  ? 88  ALA A C   1 
ATOM   682  O O   . ALA A 1 88  ? -29.443 -21.311 8.918   1.00 48.03  ? 88  ALA A O   1 
ATOM   683  C CB  . ALA A 1 88  ? -30.218 -24.072 10.447  1.00 58.90  ? 88  ALA A CB  1 
ATOM   684  N N   . GLU A 1 89  ? -28.470 -23.088 7.918   1.00 52.54  ? 89  GLU A N   1 
ATOM   685  C CA  . GLU A 1 89  ? -27.287 -22.355 7.486   1.00 53.67  ? 89  GLU A CA  1 
ATOM   686  C C   . GLU A 1 89  ? -27.545 -21.494 6.240   1.00 48.79  ? 89  GLU A C   1 
ATOM   687  O O   . GLU A 1 89  ? -26.630 -20.816 5.786   1.00 48.83  ? 89  GLU A O   1 
ATOM   688  C CB  . GLU A 1 89  ? -26.087 -23.291 7.283   1.00 55.53  ? 89  GLU A CB  1 
ATOM   689  C CG  . GLU A 1 89  ? -26.305 -24.439 6.317   1.00 60.67  ? 89  GLU A CG  1 
ATOM   690  C CD  . GLU A 1 89  ? -26.588 -25.802 6.936   1.00 67.95  ? 89  GLU A CD  1 
ATOM   691  O OE1 . GLU A 1 89  ? -26.590 -26.794 6.175   1.00 66.14  ? 89  GLU A OE1 1 
ATOM   692  O OE2 . GLU A 1 89  ? -26.815 -25.877 8.169   1.00 63.52  ? 89  GLU A OE2 1 
ATOM   693  N N   . ASP A 1 90  ? -28.776 -21.481 5.708   1.00 43.17  ? 90  ASP A N   1 
ATOM   694  C CA  . ASP A 1 90  ? -29.191 -20.483 4.734   1.00 38.84  ? 90  ASP A CA  1 
ATOM   695  C C   . ASP A 1 90  ? -29.622 -19.197 5.440   1.00 42.14  ? 90  ASP A C   1 
ATOM   696  O O   . ASP A 1 90  ? -30.043 -18.234 4.784   1.00 40.03  ? 90  ASP A O   1 
ATOM   697  C CB  . ASP A 1 90  ? -30.383 -20.933 3.892   1.00 38.55  ? 90  ASP A CB  1 
ATOM   698  C CG  . ASP A 1 90  ? -30.180 -22.208 3.098   1.00 43.91  ? 90  ASP A CG  1 
ATOM   699  O OD1 . ASP A 1 90  ? -29.067 -22.406 2.572   1.00 43.88  ? 90  ASP A OD1 1 
ATOM   700  O OD2 . ASP A 1 90  ? -31.167 -22.970 2.963   1.00 45.73  ? 90  ASP A OD2 1 
ATOM   701  N N   . THR A 1 91  ? -29.571 -19.192 6.780   1.00 38.44  ? 91  THR A N   1 
ATOM   702  C CA  . THR A 1 91  ? -29.824 -17.974 7.531   1.00 36.17  ? 91  THR A CA  1 
ATOM   703  C C   . THR A 1 91  ? -28.744 -16.955 7.172   1.00 34.27  ? 91  THR A C   1 
ATOM   704  O O   . THR A 1 91  ? -27.562 -17.204 7.385   1.00 34.81  ? 91  THR A O   1 
ATOM   705  C CB  . THR A 1 91  ? -29.897 -18.249 9.040   1.00 34.02  ? 91  THR A CB  1 
ATOM   706  O OG1 . THR A 1 91  ? -30.993 -19.143 9.256   1.00 36.02  ? 91  THR A OG1 1 
ATOM   707  C CG2 . THR A 1 91  ? -30.068 -16.987 9.858   1.00 30.79  ? 91  THR A CG2 1 
ATOM   708  N N   . ALA A 1 92  ? -29.174 -15.820 6.611   1.00 33.02  ? 92  ALA A N   1 
ATOM   709  C CA  . ALA A 1 92  ? -28.267 -14.873 5.991   1.00 32.04  ? 92  ALA A CA  1 
ATOM   710  C C   . ALA A 1 92  ? -29.038 -13.636 5.551   1.00 31.96  ? 92  ALA A C   1 
ATOM   711  O O   . ALA A 1 92  ? -30.264 -13.646 5.465   1.00 37.35  ? 92  ALA A O   1 
ATOM   712  C CB  . ALA A 1 92  ? -27.578 -15.522 4.815   1.00 31.20  ? 92  ALA A CB  1 
ATOM   713  N N   . VAL A 1 93  ? -28.305 -12.555 5.321   1.00 29.58  ? 93  VAL A N   1 
ATOM   714  C CA  . VAL A 1 93  ? -28.834 -11.430 4.584   1.00 30.48  ? 93  VAL A CA  1 
ATOM   715  C C   . VAL A 1 93  ? -28.570 -11.700 3.102   1.00 32.47  ? 93  VAL A C   1 
ATOM   716  O O   . VAL A 1 93  ? -27.461 -12.088 2.718   1.00 31.67  ? 93  VAL A O   1 
ATOM   717  C CB  . VAL A 1 93  ? -28.204 -10.110 5.068   1.00 30.65  ? 93  VAL A CB  1 
ATOM   718  C CG1 . VAL A 1 93  ? -28.617 -8.925  4.211   1.00 33.17  ? 93  VAL A CG1 1 
ATOM   719  C CG2 . VAL A 1 93  ? -28.517 -9.830  6.534   1.00 29.94  ? 93  VAL A CG2 1 
ATOM   720  N N   . TYR A 1 94  ? -29.604 -11.496 2.275   1.00 31.66  ? 94  TYR A N   1 
ATOM   721  C CA  . TYR A 1 94  ? -29.466 -11.621 0.834   1.00 28.44  ? 94  TYR A CA  1 
ATOM   722  C C   . TYR A 1 94  ? -29.662 -10.251 0.227   1.00 27.89  ? 94  TYR A C   1 
ATOM   723  O O   . TYR A 1 94  ? -30.581 -9.542  0.619   1.00 32.17  ? 94  TYR A O   1 
ATOM   724  C CB  . TYR A 1 94  ? -30.457 -12.615 0.241   1.00 26.97  ? 94  TYR A CB  1 
ATOM   725  C CG  . TYR A 1 94  ? -30.237 -14.014 0.743   1.00 29.79  ? 94  TYR A CG  1 
ATOM   726  C CD1 . TYR A 1 94  ? -30.684 -14.389 2.005   1.00 27.47  ? 94  TYR A CD1 1 
ATOM   727  C CD2 . TYR A 1 94  ? -29.493 -14.933 0.010   1.00 27.69  ? 94  TYR A CD2 1 
ATOM   728  C CE1 . TYR A 1 94  ? -30.458 -15.665 2.501   1.00 25.71  ? 94  TYR A CE1 1 
ATOM   729  C CE2 . TYR A 1 94  ? -29.272 -16.212 0.496   1.00 29.07  ? 94  TYR A CE2 1 
ATOM   730  C CZ  . TYR A 1 94  ? -29.747 -16.578 1.753   1.00 26.05  ? 94  TYR A CZ  1 
ATOM   731  O OH  . TYR A 1 94  ? -29.521 -17.837 2.277   1.00 24.96  ? 94  TYR A OH  1 
ATOM   732  N N   . TYR A 1 95  ? -28.778 -9.928  -0.715  1.00 26.47  ? 95  TYR A N   1 
ATOM   733  C CA  . TYR A 1 95  ? -28.723 -8.633  -1.369  1.00 26.57  ? 95  TYR A CA  1 
ATOM   734  C C   . TYR A 1 95  ? -28.853 -8.797  -2.884  1.00 26.83  ? 95  TYR A C   1 
ATOM   735  O O   . TYR A 1 95  ? -28.281 -9.721  -3.463  1.00 24.53  ? 95  TYR A O   1 
ATOM   736  C CB  . TYR A 1 95  ? -27.361 -7.966  -1.155  1.00 27.45  ? 95  TYR A CB  1 
ATOM   737  C CG  . TYR A 1 95  ? -27.057 -7.468  0.233   1.00 26.57  ? 95  TYR A CG  1 
ATOM   738  C CD1 . TYR A 1 95  ? -27.566 -6.267  0.705   1.00 29.67  ? 95  TYR A CD1 1 
ATOM   739  C CD2 . TYR A 1 95  ? -26.222 -8.185  1.067   1.00 25.88  ? 95  TYR A CD2 1 
ATOM   740  C CE1 . TYR A 1 95  ? -27.281 -5.817  1.990   1.00 30.47  ? 95  TYR A CE1 1 
ATOM   741  C CE2 . TYR A 1 95  ? -25.934 -7.755  2.352   1.00 29.98  ? 95  TYR A CE2 1 
ATOM   742  C CZ  . TYR A 1 95  ? -26.461 -6.564  2.817   1.00 29.91  ? 95  TYR A CZ  1 
ATOM   743  O OH  . TYR A 1 95  ? -26.119 -6.145  4.079   1.00 33.87  ? 95  TYR A OH  1 
ATOM   744  N N   . CYS A 1 96  ? -29.583 -7.869  -3.513  1.00 25.50  ? 96  CYS A N   1 
ATOM   745  C CA  . CYS A 1 96  ? -29.506 -7.677  -4.942  1.00 24.89  ? 96  CYS A CA  1 
ATOM   746  C C   . CYS A 1 96  ? -28.522 -6.534  -5.198  1.00 22.78  ? 96  CYS A C   1 
ATOM   747  O O   . CYS A 1 96  ? -28.425 -5.597  -4.418  1.00 19.76  ? 96  CYS A O   1 
ATOM   748  C CB  . CYS A 1 96  ? -30.885 -7.450  -5.557  1.00 28.41  ? 96  CYS A CB  1 
ATOM   749  S SG  . CYS A 1 96  ? -31.716 -5.926  -5.029  1.00 31.13  ? 96  CYS A SG  1 
ATOM   750  N N   . ALA A 1 97  ? -27.730 -6.672  -6.261  1.00 23.38  ? 97  ALA A N   1 
ATOM   751  C CA  . ALA A 1 97  ? -26.709 -5.699  -6.597  1.00 22.76  ? 97  ALA A CA  1 
ATOM   752  C C   . ALA A 1 97  ? -26.626 -5.610  -8.117  1.00 24.07  ? 97  ALA A C   1 
ATOM   753  O O   . ALA A 1 97  ? -26.424 -6.626  -8.786  1.00 23.84  ? 97  ALA A O   1 
ATOM   754  C CB  . ALA A 1 97  ? -25.389 -6.114  -6.007  1.00 21.47  ? 97  ALA A CB  1 
ATOM   755  N N   . ARG A 1 98  ? -26.731 -4.383  -8.626  1.00 25.55  ? 98  ARG A N   1 
ATOM   756  C CA  . ARG A 1 98  ? -26.799 -4.142  -10.062 1.00 26.25  ? 98  ARG A CA  1 
ATOM   757  C C   . ARG A 1 98  ? -25.385 -4.064  -10.640 1.00 24.61  ? 98  ARG A C   1 
ATOM   758  O O   . ARG A 1 98  ? -24.445 -3.564  -10.001 1.00 21.26  ? 98  ARG A O   1 
ATOM   759  C CB  . ARG A 1 98  ? -27.649 -2.896  -10.339 1.00 25.08  ? 98  ARG A CB  1 
ATOM   760  C CG  . ARG A 1 98  ? -28.182 -2.780  -11.762 1.00 27.47  ? 98  ARG A CG  1 
ATOM   761  C CD  . ARG A 1 98  ? -27.459 -1.688  -12.531 1.00 30.11  ? 98  ARG A CD  1 
ATOM   762  N NE  . ARG A 1 98  ? -28.106 -0.414  -12.436 1.00 31.55  ? 98  ARG A NE  1 
ATOM   763  C CZ  . ARG A 1 98  ? -27.642 0.716   -12.948 1.00 31.32  ? 98  ARG A CZ  1 
ATOM   764  N NH1 . ARG A 1 98  ? -26.359 0.890   -13.173 1.00 27.79  ? 98  ARG A NH1 1 
ATOM   765  N NH2 . ARG A 1 98  ? -28.486 1.701   -13.193 1.00 35.35  ? 98  ARG A NH2 1 
ATOM   766  N N   . ASP A 1 99  ? -25.267 -4.632  -11.847 1.00 21.94  ? 99  ASP A N   1 
ATOM   767  C CA  . ASP A 1 99  ? -24.093 -4.458  -12.681 1.00 21.37  ? 99  ASP A CA  1 
ATOM   768  C C   . ASP A 1 99  ? -23.872 -2.971  -12.869 1.00 19.74  ? 99  ASP A C   1 
ATOM   769  O O   . ASP A 1 99  ? -24.823 -2.229  -13.127 1.00 16.45  ? 99  ASP A O   1 
ATOM   770  C CB  . ASP A 1 99  ? -24.261 -5.083  -14.071 1.00 23.17  ? 99  ASP A CB  1 
ATOM   771  C CG  . ASP A 1 99  ? -24.063 -6.582  -14.168 1.00 22.80  ? 99  ASP A CG  1 
ATOM   772  O OD1 . ASP A 1 99  ? -23.662 -7.182  -13.151 1.00 22.12  ? 99  ASP A OD1 1 
ATOM   773  O OD2 . ASP A 1 99  ? -24.195 -7.116  -15.311 1.00 23.68  ? 99  ASP A OD2 1 
ATOM   774  N N   . TRP A 1 100 ? -22.599 -2.582  -12.762 1.00 18.93  ? 100 TRP A N   1 
ATOM   775  C CA  . TRP A 1 100 ? -22.107 -1.270  -13.130 1.00 20.41  ? 100 TRP A CA  1 
ATOM   776  C C   . TRP A 1 100 ? -22.550 -0.214  -12.121 1.00 23.86  ? 100 TRP A C   1 
ATOM   777  O O   . TRP A 1 100 ? -23.677 0.260   -12.138 1.00 22.16  ? 100 TRP A O   1 
ATOM   778  C CB  . TRP A 1 100 ? -22.483 -0.943  -14.580 1.00 21.85  ? 100 TRP A CB  1 
ATOM   779  C CG  . TRP A 1 100 ? -22.012 -2.011  -15.529 1.00 22.00  ? 100 TRP A CG  1 
ATOM   780  C CD1 . TRP A 1 100 ? -22.774 -2.778  -16.365 1.00 21.96  ? 100 TRP A CD1 1 
ATOM   781  C CD2 . TRP A 1 100 ? -20.655 -2.458  -15.701 1.00 21.56  ? 100 TRP A CD2 1 
ATOM   782  N NE1 . TRP A 1 100 ? -21.982 -3.658  -17.053 1.00 21.87  ? 100 TRP A NE1 1 
ATOM   783  C CE2 . TRP A 1 100 ? -20.673 -3.454  -16.697 1.00 19.89  ? 100 TRP A CE2 1 
ATOM   784  C CE3 . TRP A 1 100 ? -19.420 -2.063  -15.161 1.00 21.68  ? 100 TRP A CE3 1 
ATOM   785  C CZ2 . TRP A 1 100 ? -19.516 -4.103  -17.110 1.00 19.84  ? 100 TRP A CZ2 1 
ATOM   786  C CZ3 . TRP A 1 100 ? -18.272 -2.681  -15.602 1.00 21.28  ? 100 TRP A CZ3 1 
ATOM   787  C CH2 . TRP A 1 100 ? -18.320 -3.678  -16.572 1.00 20.79  ? 100 TRP A CH2 1 
ATOM   788  N N   . GLY A 1 101 ? -21.611 0.173   -11.246 1.00 25.02  ? 101 GLY A N   1 
ATOM   789  C CA  . GLY A 1 101 ? -21.785 1.295   -10.345 1.00 23.56  ? 101 GLY A CA  1 
ATOM   790  C C   . GLY A 1 101 ? -22.035 0.831   -8.915  1.00 23.49  ? 101 GLY A C   1 
ATOM   791  O O   . GLY A 1 101 ? -21.653 -0.277  -8.545  1.00 21.20  ? 101 GLY A O   1 
ATOM   792  N N   . PRO A 1 102 ? -22.690 1.685   -8.093  1.00 22.90  ? 102 PRO A N   1 
ATOM   793  C CA  . PRO A 1 102 ? -22.867 1.423   -6.660  1.00 23.01  ? 102 PRO A CA  1 
ATOM   794  C C   . PRO A 1 102 ? -24.155 0.802   -6.113  1.00 24.04  ? 102 PRO A C   1 
ATOM   795  O O   . PRO A 1 102 ? -24.347 0.720   -4.899  1.00 23.60  ? 102 PRO A O   1 
ATOM   796  C CB  . PRO A 1 102 ? -22.740 2.856   -6.115  1.00 23.24  ? 102 PRO A CB  1 
ATOM   797  C CG  . PRO A 1 102 ? -23.401 3.729   -7.175  1.00 24.95  ? 102 PRO A CG  1 
ATOM   798  C CD  . PRO A 1 102 ? -23.096 3.039   -8.493  1.00 22.88  ? 102 PRO A CD  1 
ATOM   799  N N   . TYR A 1 103 ? -25.022 0.269   -6.965  1.00 23.79  ? 103 TYR A N   1 
ATOM   800  C CA  . TYR A 1 103 ? -26.384 0.089   -6.510  1.00 25.28  ? 103 TYR A CA  1 
ATOM   801  C C   . TYR A 1 103 ? -26.589 -1.291  -5.899  1.00 26.59  ? 103 TYR A C   1 
ATOM   802  O O   . TYR A 1 103 ? -26.426 -2.328  -6.553  1.00 23.20  ? 103 TYR A O   1 
ATOM   803  C CB  . TYR A 1 103 ? -27.354 0.433   -7.632  1.00 27.56  ? 103 TYR A CB  1 
ATOM   804  C CG  . TYR A 1 103 ? -27.163 1.838   -8.155  1.00 26.89  ? 103 TYR A CG  1 
ATOM   805  C CD1 . TYR A 1 103 ? -27.384 2.961   -7.360  1.00 28.95  ? 103 TYR A CD1 1 
ATOM   806  C CD2 . TYR A 1 103 ? -26.723 2.042   -9.447  1.00 26.16  ? 103 TYR A CD2 1 
ATOM   807  C CE1 . TYR A 1 103 ? -27.203 4.247   -7.858  1.00 27.18  ? 103 TYR A CE1 1 
ATOM   808  C CE2 . TYR A 1 103 ? -26.554 3.313   -9.967  1.00 26.22  ? 103 TYR A CE2 1 
ATOM   809  C CZ  . TYR A 1 103 ? -26.788 4.414   -9.170  1.00 28.71  ? 103 TYR A CZ  1 
ATOM   810  O OH  . TYR A 1 103 ? -26.575 5.630   -9.762  1.00 35.08  ? 103 TYR A OH  1 
ATOM   811  N N   . TRP A 1 104 ? -26.986 -1.234  -4.620  1.00 25.48  ? 104 TRP A N   1 
ATOM   812  C CA  . TRP A 1 104 ? -27.296 -2.395  -3.811  1.00 27.61  ? 104 TRP A CA  1 
ATOM   813  C C   . TRP A 1 104 ? -28.681 -2.208  -3.207  1.00 29.54  ? 104 TRP A C   1 
ATOM   814  O O   . TRP A 1 104 ? -29.080 -1.076  -2.918  1.00 28.39  ? 104 TRP A O   1 
ATOM   815  C CB  . TRP A 1 104 ? -26.254 -2.572  -2.702  1.00 24.89  ? 104 TRP A CB  1 
ATOM   816  C CG  . TRP A 1 104 ? -24.914 -3.048  -3.165  1.00 22.30  ? 104 TRP A CG  1 
ATOM   817  C CD1 . TRP A 1 104 ? -24.001 -2.405  -3.948  1.00 21.74  ? 104 TRP A CD1 1 
ATOM   818  C CD2 . TRP A 1 104 ? -24.358 -4.328  -2.868  1.00 21.37  ? 104 TRP A CD2 1 
ATOM   819  N NE1 . TRP A 1 104 ? -22.892 -3.193  -4.127  1.00 21.56  ? 104 TRP A NE1 1 
ATOM   820  C CE2 . TRP A 1 104 ? -23.093 -4.383  -3.483  1.00 22.63  ? 104 TRP A CE2 1 
ATOM   821  C CE3 . TRP A 1 104 ? -24.798 -5.414  -2.112  1.00 23.08  ? 104 TRP A CE3 1 
ATOM   822  C CZ2 . TRP A 1 104 ? -22.270 -5.497  -3.363  1.00 21.24  ? 104 TRP A CZ2 1 
ATOM   823  C CZ3 . TRP A 1 104 ? -23.989 -6.521  -2.017  1.00 24.50  ? 104 TRP A CZ3 1 
ATOM   824  C CH2 . TRP A 1 104 ? -22.734 -6.548  -2.622  1.00 20.76  ? 104 TRP A CH2 1 
ATOM   825  N N   . GLY A 1 105 ? -29.378 -3.332  -3.025  1.00 29.28  ? 105 GLY A N   1 
ATOM   826  C CA  . GLY A 1 105 ? -30.535 -3.388  -2.148  1.00 34.96  ? 105 GLY A CA  1 
ATOM   827  C C   . GLY A 1 105 ? -30.130 -3.184  -0.689  1.00 35.02  ? 105 GLY A C   1 
ATOM   828  O O   . GLY A 1 105 ? -28.941 -3.155  -0.382  1.00 33.40  ? 105 GLY A O   1 
ATOM   829  N N   . GLN A 1 106 ? -31.131 -3.014  0.190   1.00 32.14  ? 106 GLN A N   1 
ATOM   830  C CA  . GLN A 1 106 ? -30.903 -2.858  1.619   1.00 31.28  ? 106 GLN A CA  1 
ATOM   831  C C   . GLN A 1 106 ? -30.724 -4.241  2.230   1.00 28.80  ? 106 GLN A C   1 
ATOM   832  O O   . GLN A 1 106 ? -30.295 -4.385  3.358   1.00 33.61  ? 106 GLN A O   1 
ATOM   833  C CB  . GLN A 1 106 ? -32.053 -2.092  2.278   1.00 31.52  ? 106 GLN A CB  1 
ATOM   834  C CG  . GLN A 1 106 ? -33.284 -2.940  2.561   1.00 31.76  ? 106 GLN A CG  1 
ATOM   835  C CD  . GLN A 1 106 ? -34.312 -2.974  1.454   1.00 35.21  ? 106 GLN A CD  1 
ATOM   836  O OE1 . GLN A 1 106 ? -33.989 -2.978  0.265   1.00 35.64  ? 106 GLN A OE1 1 
ATOM   837  N NE2 . GLN A 1 106 ? -35.581 -3.015  1.838   1.00 36.31  ? 106 GLN A NE2 1 
ATOM   838  N N   . GLY A 1 107 ? -31.062 -5.268  1.469   1.00 30.47  ? 107 GLY A N   1 
ATOM   839  C CA  . GLY A 1 107 ? -30.875 -6.629  1.913   1.00 31.49  ? 107 GLY A CA  1 
ATOM   840  C C   . GLY A 1 107 ? -32.102 -7.105  2.678   1.00 33.93  ? 107 GLY A C   1 
ATOM   841  O O   . GLY A 1 107 ? -32.801 -6.296  3.285   1.00 30.61  ? 107 GLY A O   1 
ATOM   842  N N   . THR A 1 108 ? -32.293 -8.428  2.633   1.00 35.12  ? 108 THR A N   1 
ATOM   843  C CA  . THR A 1 108 ? -33.420 -9.140  3.192   1.00 36.63  ? 108 THR A CA  1 
ATOM   844  C C   . THR A 1 108 ? -32.884 -10.261 4.085   1.00 38.88  ? 108 THR A C   1 
ATOM   845  O O   . THR A 1 108 ? -32.222 -11.185 3.592   1.00 36.18  ? 108 THR A O   1 
ATOM   846  C CB  . THR A 1 108 ? -34.320 -9.685  2.063   1.00 42.30  ? 108 THR A CB  1 
ATOM   847  O OG1 . THR A 1 108 ? -34.775 -8.614  1.228   1.00 40.94  ? 108 THR A OG1 1 
ATOM   848  C CG2 . THR A 1 108 ? -35.534 -10.442 2.570   1.00 41.85  ? 108 THR A CG2 1 
ATOM   849  N N   . LEU A 1 109 ? -33.180 -10.179 5.399   1.00 37.74  ? 109 LEU A N   1 
ATOM   850  C CA  . LEU A 1 109 ? -32.826 -11.238 6.333   1.00 37.43  ? 109 LEU A CA  1 
ATOM   851  C C   . LEU A 1 109 ? -33.799 -12.405 6.187   1.00 35.75  ? 109 LEU A C   1 
ATOM   852  O O   . LEU A 1 109 ? -35.010 -12.229 6.269   1.00 35.35  ? 109 LEU A O   1 
ATOM   853  C CB  . LEU A 1 109 ? -32.817 -10.684 7.763   1.00 40.69  ? 109 LEU A CB  1 
ATOM   854  C CG  . LEU A 1 109 ? -32.741 -11.719 8.891   1.00 40.05  ? 109 LEU A CG  1 
ATOM   855  C CD1 . LEU A 1 109 ? -31.455 -12.534 8.820   1.00 43.19  ? 109 LEU A CD1 1 
ATOM   856  C CD2 . LEU A 1 109 ? -32.853 -11.033 10.247  1.00 41.38  ? 109 LEU A CD2 1 
ATOM   857  N N   . VAL A 1 110 ? -33.251 -13.595 5.928   1.00 38.13  ? 110 VAL A N   1 
ATOM   858  C CA  . VAL A 1 110 ? -34.007 -14.832 5.934   1.00 38.22  ? 110 VAL A CA  1 
ATOM   859  C C   . VAL A 1 110 ? -33.456 -15.664 7.090   1.00 40.96  ? 110 VAL A C   1 
ATOM   860  O O   . VAL A 1 110 ? -32.257 -15.918 7.122   1.00 41.40  ? 110 VAL A O   1 
ATOM   861  C CB  . VAL A 1 110 ? -33.920 -15.581 4.586   1.00 37.24  ? 110 VAL A CB  1 
ATOM   862  C CG1 . VAL A 1 110 ? -34.652 -16.912 4.605   1.00 32.53  ? 110 VAL A CG1 1 
ATOM   863  C CG2 . VAL A 1 110 ? -34.436 -14.739 3.431   1.00 40.66  ? 110 VAL A CG2 1 
ATOM   864  N N   . THR A 1 111 ? -34.335 -16.036 8.039   1.00 39.53  ? 111 THR A N   1 
ATOM   865  C CA  . THR A 1 111 ? -33.961 -16.849 9.188   1.00 40.29  ? 111 THR A CA  1 
ATOM   866  C C   . THR A 1 111 ? -34.620 -18.217 9.066   1.00 41.42  ? 111 THR A C   1 
ATOM   867  O O   . THR A 1 111 ? -35.832 -18.307 8.927   1.00 46.70  ? 111 THR A O   1 
ATOM   868  C CB  . THR A 1 111 ? -34.359 -16.174 10.506  1.00 38.20  ? 111 THR A CB  1 
ATOM   869  O OG1 . THR A 1 111 ? -34.008 -14.799 10.436  1.00 37.16  ? 111 THR A OG1 1 
ATOM   870  C CG2 . THR A 1 111 ? -33.689 -16.778 11.720  1.00 38.05  ? 111 THR A CG2 1 
ATOM   871  N N   . VAL A 1 112 ? -33.822 -19.282 9.091   1.00 43.65  ? 112 VAL A N   1 
ATOM   872  C CA  . VAL A 1 112 ? -34.384 -20.620 9.084   1.00 49.97  ? 112 VAL A CA  1 
ATOM   873  C C   . VAL A 1 112 ? -34.302 -21.213 10.494  1.00 56.39  ? 112 VAL A C   1 
ATOM   874  O O   . VAL A 1 112 ? -33.212 -21.458 11.017  1.00 55.02  ? 112 VAL A O   1 
ATOM   875  C CB  . VAL A 1 112 ? -33.691 -21.524 8.053   1.00 47.76  ? 112 VAL A CB  1 
ATOM   876  C CG1 . VAL A 1 112 ? -34.397 -22.864 7.940   1.00 47.82  ? 112 VAL A CG1 1 
ATOM   877  C CG2 . VAL A 1 112 ? -33.615 -20.844 6.698   1.00 50.88  ? 112 VAL A CG2 1 
ATOM   878  N N   . SER A 1 113 ? -35.477 -21.452 11.095  1.00 56.45  ? 113 SER A N   1 
ATOM   879  C CA  . SER A 1 113 ? -35.567 -21.991 12.443  1.00 59.11  ? 113 SER A CA  1 
ATOM   880  C C   . SER A 1 113 ? -36.935 -22.627 12.668  1.00 59.59  ? 113 SER A C   1 
ATOM   881  O O   . SER A 1 113 ? -37.933 -22.196 12.087  1.00 56.43  ? 113 SER A O   1 
ATOM   882  C CB  . SER A 1 113 ? -35.304 -20.915 13.464  1.00 59.18  ? 113 SER A CB  1 
ATOM   883  O OG  . SER A 1 113 ? -35.415 -21.422 14.782  1.00 66.45  ? 113 SER A OG  1 
ATOM   884  N N   . SER A 1 114 ? -36.959 -23.640 13.544  1.00 64.27  ? 114 SER A N   1 
ATOM   885  C CA  . SER A 1 114 ? -38.192 -24.266 13.996  1.00 58.40  ? 114 SER A CA  1 
ATOM   886  C C   . SER A 1 114 ? -38.946 -23.353 14.960  1.00 57.43  ? 114 SER A C   1 
ATOM   887  O O   . SER A 1 114 ? -40.171 -23.278 14.906  1.00 59.41  ? 114 SER A O   1 
ATOM   888  C CB  . SER A 1 114 ? -37.903 -25.589 14.619  1.00 54.78  ? 114 SER A CB  1 
ATOM   889  O OG  . SER A 1 114 ? -37.490 -26.498 13.614  1.00 54.20  ? 114 SER A OG  1 
ATOM   890  N N   . ALA A 1 115 ? -38.200 -22.633 15.802  1.00 53.88  ? 115 ALA A N   1 
ATOM   891  C CA  . ALA A 1 115 ? -38.776 -21.838 16.874  1.00 56.00  ? 115 ALA A CA  1 
ATOM   892  C C   . ALA A 1 115 ? -39.802 -20.845 16.330  1.00 57.07  ? 115 ALA A C   1 
ATOM   893  O O   . ALA A 1 115 ? -39.811 -20.541 15.141  1.00 55.72  ? 115 ALA A O   1 
ATOM   894  C CB  . ALA A 1 115 ? -37.676 -21.131 17.633  1.00 52.48  ? 115 ALA A CB  1 
ATOM   895  N N   . SER A 1 116 ? -40.628 -20.319 17.246  1.00 57.94  ? 116 SER A N   1 
ATOM   896  C CA  . SER A 1 116 ? -41.751 -19.451 16.929  1.00 57.80  ? 116 SER A CA  1 
ATOM   897  C C   . SER A 1 116 ? -41.404 -17.988 17.202  1.00 60.58  ? 116 SER A C   1 
ATOM   898  O O   . SER A 1 116 ? -40.500 -17.690 17.986  1.00 62.73  ? 116 SER A O   1 
ATOM   899  C CB  . SER A 1 116 ? -42.969 -19.856 17.732  1.00 59.55  ? 116 SER A CB  1 
ATOM   900  O OG  . SER A 1 116 ? -43.368 -21.187 17.438  1.00 57.82  ? 116 SER A OG  1 
ATOM   901  N N   . THR A 1 117 ? -42.162 -17.085 16.561  1.00 60.87  ? 117 THR A N   1 
ATOM   902  C CA  . THR A 1 117 ? -42.124 -15.655 16.847  1.00 64.84  ? 117 THR A CA  1 
ATOM   903  C C   . THR A 1 117 ? -42.561 -15.410 18.294  1.00 66.11  ? 117 THR A C   1 
ATOM   904  O O   . THR A 1 117 ? -43.636 -15.845 18.700  1.00 65.53  ? 117 THR A O   1 
ATOM   905  C CB  . THR A 1 117 ? -43.009 -14.876 15.856  1.00 64.76  ? 117 THR A CB  1 
ATOM   906  O OG1 . THR A 1 117 ? -42.470 -15.011 14.539  1.00 64.15  ? 117 THR A OG1 1 
ATOM   907  C CG2 . THR A 1 117 ? -43.128 -13.402 16.178  1.00 61.40  ? 117 THR A CG2 1 
ATOM   908  N N   . LYS A 1 118 ? -41.723 -14.704 19.064  1.00 64.87  ? 118 LYS A N   1 
ATOM   909  C CA  . LYS A 1 118 ? -42.025 -14.388 20.448  1.00 61.86  ? 118 LYS A CA  1 
ATOM   910  C C   . LYS A 1 118 ? -41.485 -13.001 20.780  1.00 60.96  ? 118 LYS A C   1 
ATOM   911  O O   . LYS A 1 118 ? -40.288 -12.750 20.657  1.00 62.43  ? 118 LYS A O   1 
ATOM   912  C CB  . LYS A 1 118 ? -41.420 -15.447 21.373  1.00 69.86  ? 118 LYS A CB  1 
ATOM   913  C CG  . LYS A 1 118 ? -41.690 -15.233 22.858  1.00 72.57  ? 118 LYS A CG  1 
ATOM   914  C CD  . LYS A 1 118 ? -41.402 -16.456 23.717  1.00 76.89  ? 118 LYS A CD  1 
ATOM   915  C CE  . LYS A 1 118 ? -41.565 -16.198 25.201  1.00 77.49  ? 118 LYS A CE  1 
ATOM   916  N NZ  . LYS A 1 118 ? -40.773 -15.022 25.641  1.00 79.62  ? 118 LYS A NZ  1 
ATOM   917  N N   . GLY A 1 119 ? -42.376 -12.098 21.201  1.00 55.91  ? 119 GLY A N   1 
ATOM   918  C CA  . GLY A 1 119 ? -41.980 -10.734 21.508  1.00 51.57  ? 119 GLY A CA  1 
ATOM   919  C C   . GLY A 1 119 ? -41.240 -10.654 22.841  1.00 53.27  ? 119 GLY A C   1 
ATOM   920  O O   . GLY A 1 119 ? -41.488 -11.460 23.734  1.00 51.23  ? 119 GLY A O   1 
ATOM   921  N N   . PRO A 1 120 ? -40.335 -9.662  23.030  1.00 53.51  ? 120 PRO A N   1 
ATOM   922  C CA  . PRO A 1 120 ? -39.561 -9.542  24.267  1.00 56.70  ? 120 PRO A CA  1 
ATOM   923  C C   . PRO A 1 120 ? -40.398 -9.141  25.481  1.00 59.43  ? 120 PRO A C   1 
ATOM   924  O O   . PRO A 1 120 ? -41.612 -8.957  25.368  1.00 53.66  ? 120 PRO A O   1 
ATOM   925  C CB  . PRO A 1 120 ? -38.556 -8.414  23.974  1.00 57.56  ? 120 PRO A CB  1 
ATOM   926  C CG  . PRO A 1 120 ? -39.214 -7.585  22.885  1.00 56.67  ? 120 PRO A CG  1 
ATOM   927  C CD  . PRO A 1 120 ? -40.054 -8.567  22.088  1.00 55.34  ? 120 PRO A CD  1 
ATOM   928  N N   . SER A 1 121 ? -39.713 -9.061  26.631  1.00 57.09  ? 121 SER A N   1 
ATOM   929  C CA  . SER A 1 121 ? -40.180 -8.374  27.822  1.00 55.12  ? 121 SER A CA  1 
ATOM   930  C C   . SER A 1 121 ? -39.165 -7.286  28.126  1.00 53.82  ? 121 SER A C   1 
ATOM   931  O O   . SER A 1 121 ? -37.962 -7.524  28.031  1.00 57.76  ? 121 SER A O   1 
ATOM   932  C CB  . SER A 1 121 ? -40.321 -9.315  28.998  1.00 57.93  ? 121 SER A CB  1 
ATOM   933  O OG  . SER A 1 121 ? -41.179 -10.408 28.690  1.00 62.76  ? 121 SER A OG  1 
ATOM   934  N N   . VAL A 1 122 ? -39.638 -6.091  28.464  1.00 50.23  ? 122 VAL A N   1 
ATOM   935  C CA  . VAL A 1 122 ? -38.714 -4.994  28.694  1.00 55.43  ? 122 VAL A CA  1 
ATOM   936  C C   . VAL A 1 122 ? -38.656 -4.714  30.193  1.00 64.37  ? 122 VAL A C   1 
ATOM   937  O O   . VAL A 1 122 ? -39.678 -4.744  30.882  1.00 73.16  ? 122 VAL A O   1 
ATOM   938  C CB  . VAL A 1 122 ? -39.072 -3.740  27.869  1.00 57.23  ? 122 VAL A CB  1 
ATOM   939  C CG1 . VAL A 1 122 ? -38.048 -2.624  28.047  1.00 56.33  ? 122 VAL A CG1 1 
ATOM   940  C CG2 . VAL A 1 122 ? -39.243 -4.065  26.388  1.00 58.47  ? 122 VAL A CG2 1 
ATOM   941  N N   . PHE A 1 123 ? -37.434 -4.445  30.676  1.00 60.58  ? 123 PHE A N   1 
ATOM   942  C CA  . PHE A 1 123 ? -37.158 -4.294  32.091  1.00 55.64  ? 123 PHE A CA  1 
ATOM   943  C C   . PHE A 1 123 ? -36.166 -3.156  32.289  1.00 60.91  ? 123 PHE A C   1 
ATOM   944  O O   . PHE A 1 123 ? -35.145 -3.101  31.608  1.00 64.25  ? 123 PHE A O   1 
ATOM   945  C CB  . PHE A 1 123 ? -36.604 -5.594  32.673  1.00 53.64  ? 123 PHE A CB  1 
ATOM   946  C CG  . PHE A 1 123 ? -37.521 -6.786  32.553  1.00 52.79  ? 123 PHE A CG  1 
ATOM   947  C CD1 . PHE A 1 123 ? -38.886 -6.671  32.793  1.00 53.02  ? 123 PHE A CD1 1 
ATOM   948  C CD2 . PHE A 1 123 ? -37.011 -8.040  32.242  1.00 48.85  ? 123 PHE A CD2 1 
ATOM   949  C CE1 . PHE A 1 123 ? -39.720 -7.777  32.699  1.00 50.44  ? 123 PHE A CE1 1 
ATOM   950  C CE2 . PHE A 1 123 ? -37.846 -9.143  32.147  1.00 48.96  ? 123 PHE A CE2 1 
ATOM   951  C CZ  . PHE A 1 123 ? -39.200 -9.009  32.371  1.00 50.69  ? 123 PHE A CZ  1 
ATOM   952  N N   . PRO A 1 124 ? -36.425 -2.208  33.218  1.00 60.77  ? 124 PRO A N   1 
ATOM   953  C CA  . PRO A 1 124 ? -35.521 -1.075  33.410  1.00 59.53  ? 124 PRO A CA  1 
ATOM   954  C C   . PRO A 1 124 ? -34.226 -1.538  34.063  1.00 57.88  ? 124 PRO A C   1 
ATOM   955  O O   . PRO A 1 124 ? -34.210 -2.570  34.727  1.00 55.79  ? 124 PRO A O   1 
ATOM   956  C CB  . PRO A 1 124 ? -36.300 -0.147  34.353  1.00 61.14  ? 124 PRO A CB  1 
ATOM   957  C CG  . PRO A 1 124 ? -37.167 -1.111  35.147  1.00 59.30  ? 124 PRO A CG  1 
ATOM   958  C CD  . PRO A 1 124 ? -37.567 -2.180  34.147  1.00 59.70  ? 124 PRO A CD  1 
ATOM   959  N N   . LEU A 1 125 ? -33.159 -0.771  33.836  1.00 57.03  ? 125 LEU A N   1 
ATOM   960  C CA  . LEU A 1 125 ? -31.949 -0.857  34.631  1.00 68.37  ? 125 LEU A CA  1 
ATOM   961  C C   . LEU A 1 125 ? -31.722 0.525   35.253  1.00 77.70  ? 125 LEU A C   1 
ATOM   962  O O   . LEU A 1 125 ? -30.965 1.336   34.718  1.00 72.97  ? 125 LEU A O   1 
ATOM   963  C CB  . LEU A 1 125 ? -30.773 -1.293  33.742  1.00 71.24  ? 125 LEU A CB  1 
ATOM   964  C CG  . LEU A 1 125 ? -30.962 -2.554  32.892  1.00 67.83  ? 125 LEU A CG  1 
ATOM   965  C CD1 . LEU A 1 125 ? -29.702 -2.837  32.093  1.00 65.41  ? 125 LEU A CD1 1 
ATOM   966  C CD2 . LEU A 1 125 ? -31.314 -3.773  33.733  1.00 66.74  ? 125 LEU A CD2 1 
ATOM   967  N N   . ALA A 1 126 ? -32.402 0.787   36.383  1.00 81.69  ? 126 ALA A N   1 
ATOM   968  C CA  . ALA A 1 126 ? -32.550 2.138   36.908  1.00 78.86  ? 126 ALA A CA  1 
ATOM   969  C C   . ALA A 1 126 ? -31.256 2.603   37.571  1.00 80.10  ? 126 ALA A C   1 
ATOM   970  O O   . ALA A 1 126 ? -30.474 1.782   38.048  1.00 78.53  ? 126 ALA A O   1 
ATOM   971  C CB  . ALA A 1 126 ? -33.704 2.182   37.875  1.00 81.73  ? 126 ALA A CB  1 
ATOM   972  N N   . PRO A 1 127 ? -30.988 3.931   37.618  1.00 85.16  ? 127 PRO A N   1 
ATOM   973  C CA  . PRO A 1 127 ? -29.782 4.463   38.263  1.00 87.14  ? 127 PRO A CA  1 
ATOM   974  C C   . PRO A 1 127 ? -29.953 4.616   39.774  1.00 91.92  ? 127 PRO A C   1 
ATOM   975  O O   . PRO A 1 127 ? -31.062 4.485   40.283  1.00 97.57  ? 127 PRO A O   1 
ATOM   976  C CB  . PRO A 1 127 ? -29.616 5.827   37.579  1.00 88.31  ? 127 PRO A CB  1 
ATOM   977  C CG  . PRO A 1 127 ? -31.043 6.267   37.287  1.00 87.57  ? 127 PRO A CG  1 
ATOM   978  C CD  . PRO A 1 127 ? -31.832 4.993   37.045  1.00 83.31  ? 127 PRO A CD  1 
ATOM   979  N N   . SER A 1 128 ? -28.852 4.890   40.486  1.00 99.96  ? 128 SER A N   1 
ATOM   980  C CA  . SER A 1 128 ? -28.897 5.055   41.934  1.00 103.52 ? 128 SER A CA  1 
ATOM   981  C C   . SER A 1 128 ? -27.645 5.772   42.434  1.00 104.56 ? 128 SER A C   1 
ATOM   982  O O   . SER A 1 128 ? -26.725 6.042   41.663  1.00 107.31 ? 128 SER A O   1 
ATOM   983  C CB  . SER A 1 128 ? -29.052 3.721   42.639  1.00 103.78 ? 128 SER A CB  1 
ATOM   984  O OG  . SER A 1 128 ? -27.807 3.041   42.735  1.00 102.65 ? 128 SER A OG  1 
ATOM   985  N N   . SER A 1 129 ? -27.650 6.083   43.737  1.00 100.30 ? 129 SER A N   1 
ATOM   986  C CA  . SER A 1 129 ? -26.436 6.328   44.497  1.00 94.43  ? 129 SER A CA  1 
ATOM   987  C C   . SER A 1 129 ? -25.551 7.367   43.793  1.00 86.73  ? 129 SER A C   1 
ATOM   988  O O   . SER A 1 129 ? -24.415 7.580   44.266  1.00 68.11  ? 129 SER A O   1 
ATOM   989  C CB  . SER A 1 129 ? -25.721 5.016   44.722  1.00 93.26  ? 129 SER A CB  1 
ATOM   990  O OG  . SER A 1 129 ? -24.631 5.179   45.609  1.00 92.57  ? 129 SER A OG  1 
ATOM   991  N N   . GLY A 1 135 ? -20.963 13.278  39.149  1.00 90.93  ? 135 GLY A N   1 
ATOM   992  C CA  . GLY A 1 135 ? -20.630 13.368  37.713  1.00 88.08  ? 135 GLY A CA  1 
ATOM   993  C C   . GLY A 1 135 ? -21.683 12.704  36.826  1.00 87.37  ? 135 GLY A C   1 
ATOM   994  O O   . GLY A 1 135 ? -22.545 13.391  36.285  1.00 86.36  ? 135 GLY A O   1 
ATOM   995  N N   . THR A 1 136 ? -21.620 11.365  36.710  1.00 85.33  ? 136 THR A N   1 
ATOM   996  C CA  . THR A 1 136 ? -22.344 10.620  35.687  1.00 77.48  ? 136 THR A CA  1 
ATOM   997  C C   . THR A 1 136 ? -23.058 9.408   36.285  1.00 71.02  ? 136 THR A C   1 
ATOM   998  O O   . THR A 1 136 ? -22.472 8.681   37.086  1.00 66.07  ? 136 THR A O   1 
ATOM   999  C CB  . THR A 1 136 ? -21.383 10.153  34.584  1.00 79.18  ? 136 THR A CB  1 
ATOM   1000 O OG1 . THR A 1 136 ? -20.795 11.304  33.972  1.00 80.50  ? 136 THR A OG1 1 
ATOM   1001 C CG2 . THR A 1 136 ? -22.045 9.302   33.521  1.00 75.10  ? 136 THR A CG2 1 
ATOM   1002 N N   . ALA A 1 137 ? -24.302 9.174   35.832  1.00 67.10  ? 137 ALA A N   1 
ATOM   1003 C CA  . ALA A 1 137 ? -25.102 8.022   36.234  1.00 69.61  ? 137 ALA A CA  1 
ATOM   1004 C C   . ALA A 1 137 ? -25.650 7.277   35.015  1.00 78.33  ? 137 ALA A C   1 
ATOM   1005 O O   . ALA A 1 137 ? -26.376 7.843   34.197  1.00 83.99  ? 137 ALA A O   1 
ATOM   1006 C CB  . ALA A 1 137 ? -26.240 8.465   37.118  1.00 68.95  ? 137 ALA A CB  1 
ATOM   1007 N N   . ALA A 1 138 ? -25.347 5.975   34.939  1.00 79.08  ? 138 ALA A N   1 
ATOM   1008 C CA  . ALA A 1 138 ? -25.770 5.139   33.827  1.00 77.13  ? 138 ALA A CA  1 
ATOM   1009 C C   . ALA A 1 138 ? -27.158 4.560   34.097  1.00 61.50  ? 138 ALA A C   1 
ATOM   1010 O O   . ALA A 1 138 ? -27.489 4.224   35.222  1.00 64.10  ? 138 ALA A O   1 
ATOM   1011 C CB  . ALA A 1 138 ? -24.747 4.048   33.609  1.00 82.45  ? 138 ALA A CB  1 
ATOM   1012 N N   . LEU A 1 139 ? -27.969 4.450   33.047  1.00 59.96  ? 139 LEU A N   1 
ATOM   1013 C CA  . LEU A 1 139 ? -29.273 3.814   33.129  1.00 60.54  ? 139 LEU A CA  1 
ATOM   1014 C C   . LEU A 1 139 ? -29.544 3.129   31.790  1.00 59.01  ? 139 LEU A C   1 
ATOM   1015 O O   . LEU A 1 139 ? -28.905 3.451   30.786  1.00 56.85  ? 139 LEU A O   1 
ATOM   1016 C CB  . LEU A 1 139 ? -30.327 4.882   33.451  1.00 61.97  ? 139 LEU A CB  1 
ATOM   1017 C CG  . LEU A 1 139 ? -30.642 5.873   32.325  1.00 62.22  ? 139 LEU A CG  1 
ATOM   1018 C CD1 . LEU A 1 139 ? -31.924 5.490   31.595  1.00 61.71  ? 139 LEU A CD1 1 
ATOM   1019 C CD2 . LEU A 1 139 ? -30.739 7.301   32.846  1.00 59.76  ? 139 LEU A CD2 1 
ATOM   1020 N N   . GLY A 1 140 ? -30.509 2.209   31.767  1.00 54.82  ? 140 GLY A N   1 
ATOM   1021 C CA  . GLY A 1 140 ? -30.720 1.406   30.578  1.00 57.23  ? 140 GLY A CA  1 
ATOM   1022 C C   . GLY A 1 140 ? -32.050 0.662   30.579  1.00 59.55  ? 140 GLY A C   1 
ATOM   1023 O O   . GLY A 1 140 ? -32.919 0.946   31.406  1.00 65.75  ? 140 GLY A O   1 
ATOM   1024 N N   . CYS A 1 141 ? -32.170 -0.244  29.595  1.00 56.13  ? 141 CYS A N   1 
ATOM   1025 C CA  . CYS A 1 141 ? -33.266 -1.189  29.436  1.00 64.46  ? 141 CYS A CA  1 
ATOM   1026 C C   . CYS A 1 141 ? -32.711 -2.572  29.097  1.00 65.76  ? 141 CYS A C   1 
ATOM   1027 O O   . CYS A 1 141 ? -31.709 -2.686  28.393  1.00 64.82  ? 141 CYS A O   1 
ATOM   1028 C CB  . CYS A 1 141 ? -34.190 -0.811  28.285  1.00 66.42  ? 141 CYS A CB  1 
ATOM   1029 S SG  . CYS A 1 141 ? -35.322 0.539   28.685  1.00 81.30  ? 141 CYS A SG  1 
ATOM   1030 N N   . LEU A 1 142 ? -33.403 -3.607  29.581  1.00 63.03  ? 142 LEU A N   1 
ATOM   1031 C CA  . LEU A 1 142 ? -33.099 -4.990  29.262  1.00 57.50  ? 142 LEU A CA  1 
ATOM   1032 C C   . LEU A 1 142 ? -34.264 -5.527  28.451  1.00 52.77  ? 142 LEU A C   1 
ATOM   1033 O O   . LEU A 1 142 ? -35.412 -5.309  28.827  1.00 49.14  ? 142 LEU A O   1 
ATOM   1034 C CB  . LEU A 1 142 ? -32.894 -5.790  30.556  1.00 56.39  ? 142 LEU A CB  1 
ATOM   1035 C CG  . LEU A 1 142 ? -32.746 -7.304  30.396  1.00 55.60  ? 142 LEU A CG  1 
ATOM   1036 C CD1 . LEU A 1 142 ? -31.443 -7.662  29.689  1.00 59.77  ? 142 LEU A CD1 1 
ATOM   1037 C CD2 . LEU A 1 142 ? -32.810 -8.000  31.749  1.00 55.22  ? 142 LEU A CD2 1 
ATOM   1038 N N   . VAL A 1 143 ? -33.941 -6.185  27.333  1.00 51.35  ? 143 VAL A N   1 
ATOM   1039 C CA  . VAL A 1 143 ? -34.926 -6.658  26.375  1.00 51.73  ? 143 VAL A CA  1 
ATOM   1040 C C   . VAL A 1 143 ? -34.747 -8.163  26.262  1.00 51.37  ? 143 VAL A C   1 
ATOM   1041 O O   . VAL A 1 143 ? -33.790 -8.625  25.645  1.00 55.38  ? 143 VAL A O   1 
ATOM   1042 C CB  . VAL A 1 143 ? -34.762 -5.984  24.995  1.00 51.20  ? 143 VAL A CB  1 
ATOM   1043 C CG1 . VAL A 1 143 ? -35.881 -6.384  24.038  1.00 50.96  ? 143 VAL A CG1 1 
ATOM   1044 C CG2 . VAL A 1 143 ? -34.662 -4.468  25.088  1.00 51.54  ? 143 VAL A CG2 1 
ATOM   1045 N N   . LYS A 1 144 ? -35.670 -8.922  26.844  1.00 54.18  ? 144 LYS A N   1 
ATOM   1046 C CA  . LYS A 1 144 ? -35.365 -10.304 27.162  1.00 55.88  ? 144 LYS A CA  1 
ATOM   1047 C C   . LYS A 1 144 ? -36.372 -11.246 26.510  1.00 56.03  ? 144 LYS A C   1 
ATOM   1048 O O   . LYS A 1 144 ? -37.550 -10.930 26.393  1.00 57.02  ? 144 LYS A O   1 
ATOM   1049 C CB  . LYS A 1 144 ? -35.260 -10.452 28.684  1.00 59.46  ? 144 LYS A CB  1 
ATOM   1050 C CG  . LYS A 1 144 ? -34.789 -11.821 29.158  1.00 61.68  ? 144 LYS A CG  1 
ATOM   1051 C CD  . LYS A 1 144 ? -33.926 -11.785 30.411  1.00 63.10  ? 144 LYS A CD  1 
ATOM   1052 C CE  . LYS A 1 144 ? -33.346 -13.138 30.776  1.00 62.40  ? 144 LYS A CE  1 
ATOM   1053 N NZ  . LYS A 1 144 ? -34.402 -14.161 30.981  1.00 58.88  ? 144 LYS A NZ  1 
ATOM   1054 N N   . ASP A 1 145 ? -35.838 -12.384 26.042  1.00 63.73  ? 145 ASP A N   1 
ATOM   1055 C CA  . ASP A 1 145 ? -36.577 -13.559 25.603  1.00 66.44  ? 145 ASP A CA  1 
ATOM   1056 C C   . ASP A 1 145 ? -37.429 -13.245 24.375  1.00 68.57  ? 145 ASP A C   1 
ATOM   1057 O O   . ASP A 1 145 ? -38.613 -13.583 24.347  1.00 69.21  ? 145 ASP A O   1 
ATOM   1058 C CB  . ASP A 1 145 ? -37.381 -14.180 26.751  1.00 67.86  ? 145 ASP A CB  1 
ATOM   1059 C CG  . ASP A 1 145 ? -36.516 -14.699 27.892  1.00 66.70  ? 145 ASP A CG  1 
ATOM   1060 O OD1 . ASP A 1 145 ? -35.635 -15.561 27.646  1.00 63.26  ? 145 ASP A OD1 1 
ATOM   1061 O OD2 . ASP A 1 145 ? -36.736 -14.249 29.022  1.00 66.92  ? 145 ASP A OD2 1 
ATOM   1062 N N   . TYR A 1 146 ? -36.797 -12.669 23.339  1.00 60.67  ? 146 TYR A N   1 
ATOM   1063 C CA  . TYR A 1 146 ? -37.462 -12.428 22.068  1.00 59.31  ? 146 TYR A CA  1 
ATOM   1064 C C   . TYR A 1 146 ? -36.840 -13.291 20.968  1.00 60.83  ? 146 TYR A C   1 
ATOM   1065 O O   . TYR A 1 146 ? -35.639 -13.553 20.987  1.00 60.11  ? 146 TYR A O   1 
ATOM   1066 C CB  . TYR A 1 146 ? -37.400 -10.944 21.713  1.00 55.15  ? 146 TYR A CB  1 
ATOM   1067 C CG  . TYR A 1 146 ? -36.039 -10.437 21.315  1.00 58.40  ? 146 TYR A CG  1 
ATOM   1068 C CD1 . TYR A 1 146 ? -35.553 -10.622 20.030  1.00 59.11  ? 146 TYR A CD1 1 
ATOM   1069 C CD2 . TYR A 1 146 ? -35.232 -9.780  22.227  1.00 61.86  ? 146 TYR A CD2 1 
ATOM   1070 C CE1 . TYR A 1 146 ? -34.304 -10.155 19.658  1.00 62.40  ? 146 TYR A CE1 1 
ATOM   1071 C CE2 . TYR A 1 146 ? -33.979 -9.309  21.875  1.00 60.57  ? 146 TYR A CE2 1 
ATOM   1072 C CZ  . TYR A 1 146 ? -33.515 -9.498  20.585  1.00 62.10  ? 146 TYR A CZ  1 
ATOM   1073 O OH  . TYR A 1 146 ? -32.281 -9.035  20.229  1.00 57.18  ? 146 TYR A OH  1 
ATOM   1074 N N   . PHE A 1 147 ? -37.671 -13.709 20.002  1.00 52.53  ? 147 PHE A N   1 
ATOM   1075 C CA  . PHE A 1 147 ? -37.201 -14.417 18.824  1.00 53.62  ? 147 PHE A CA  1 
ATOM   1076 C C   . PHE A 1 147 ? -38.041 -14.065 17.592  1.00 59.86  ? 147 PHE A C   1 
ATOM   1077 O O   . PHE A 1 147 ? -39.254 -13.889 17.710  1.00 63.44  ? 147 PHE A O   1 
ATOM   1078 C CB  . PHE A 1 147 ? -37.258 -15.923 19.069  1.00 51.60  ? 147 PHE A CB  1 
ATOM   1079 C CG  . PHE A 1 147 ? -36.668 -16.736 17.951  1.00 49.79  ? 147 PHE A CG  1 
ATOM   1080 C CD1 . PHE A 1 147 ? -35.291 -16.858 17.819  1.00 52.02  ? 147 PHE A CD1 1 
ATOM   1081 C CD2 . PHE A 1 147 ? -37.481 -17.327 17.003  1.00 50.07  ? 147 PHE A CD2 1 
ATOM   1082 C CE1 . PHE A 1 147 ? -34.741 -17.590 16.781  1.00 49.03  ? 147 PHE A CE1 1 
ATOM   1083 C CE2 . PHE A 1 147 ? -36.926 -18.057 15.965  1.00 52.98  ? 147 PHE A CE2 1 
ATOM   1084 C CZ  . PHE A 1 147 ? -35.562 -18.188 15.859  1.00 49.65  ? 147 PHE A CZ  1 
ATOM   1085 N N   . PRO A 1 148 ? -37.460 -13.979 16.364  1.00 55.86  ? 148 PRO A N   1 
ATOM   1086 C CA  . PRO A 1 148 ? -36.014 -13.959 16.140  1.00 50.21  ? 148 PRO A CA  1 
ATOM   1087 C C   . PRO A 1 148 ? -35.461 -12.543 16.125  1.00 49.66  ? 148 PRO A C   1 
ATOM   1088 O O   . PRO A 1 148 ? -36.134 -11.608 16.558  1.00 46.41  ? 148 PRO A O   1 
ATOM   1089 C CB  . PRO A 1 148 ? -35.904 -14.601 14.758  1.00 54.31  ? 148 PRO A CB  1 
ATOM   1090 C CG  . PRO A 1 148 ? -37.110 -14.055 14.036  1.00 57.63  ? 148 PRO A CG  1 
ATOM   1091 C CD  . PRO A 1 148 ? -38.197 -14.000 15.092  1.00 55.85  ? 148 PRO A CD  1 
ATOM   1092 N N   . GLU A 1 149 ? -34.221 -12.398 15.650  1.00 43.15  ? 149 GLU A N   1 
ATOM   1093 C CA  . GLU A 1 149 ? -33.651 -11.071 15.523  1.00 46.92  ? 149 GLU A CA  1 
ATOM   1094 C C   . GLU A 1 149 ? -34.327 -10.338 14.369  1.00 39.57  ? 149 GLU A C   1 
ATOM   1095 O O   . GLU A 1 149 ? -34.917 -10.974 13.499  1.00 37.32  ? 149 GLU A O   1 
ATOM   1096 C CB  . GLU A 1 149 ? -32.143 -11.156 15.287  1.00 52.89  ? 149 GLU A CB  1 
ATOM   1097 C CG  . GLU A 1 149 ? -31.344 -11.229 16.564  1.00 53.34  ? 149 GLU A CG  1 
ATOM   1098 C CD  . GLU A 1 149 ? -29.861 -11.440 16.343  1.00 54.14  ? 149 GLU A CD  1 
ATOM   1099 O OE1 . GLU A 1 149 ? -29.086 -10.530 16.706  1.00 51.53  ? 149 GLU A OE1 1 
ATOM   1100 O OE2 . GLU A 1 149 ? -29.489 -12.523 15.819  1.00 59.63  ? 149 GLU A OE2 1 
ATOM   1101 N N   . PRO A 1 150 ? -34.225 -8.994  14.287  1.00 36.93  ? 150 PRO A N   1 
ATOM   1102 C CA  . PRO A 1 150 ? -33.630 -8.149  15.331  1.00 40.71  ? 150 PRO A CA  1 
ATOM   1103 C C   . PRO A 1 150 ? -34.638 -7.374  16.181  1.00 43.02  ? 150 PRO A C   1 
ATOM   1104 O O   . PRO A 1 150 ? -35.836 -7.563  16.022  1.00 42.08  ? 150 PRO A O   1 
ATOM   1105 C CB  . PRO A 1 150 ? -32.891 -7.108  14.470  1.00 39.62  ? 150 PRO A CB  1 
ATOM   1106 C CG  . PRO A 1 150 ? -33.853 -6.879  13.288  1.00 36.71  ? 150 PRO A CG  1 
ATOM   1107 C CD  . PRO A 1 150 ? -34.577 -8.203  13.094  1.00 35.67  ? 150 PRO A CD  1 
ATOM   1108 N N   . VAL A 1 151 ? -34.129 -6.477  17.040  1.00 46.77  ? 151 VAL A N   1 
ATOM   1109 C CA  . VAL A 1 151 ? -34.932 -5.443  17.673  1.00 50.53  ? 151 VAL A CA  1 
ATOM   1110 C C   . VAL A 1 151 ? -34.153 -4.140  17.591  1.00 53.51  ? 151 VAL A C   1 
ATOM   1111 O O   . VAL A 1 151 ? -32.925 -4.163  17.556  1.00 54.93  ? 151 VAL A O   1 
ATOM   1112 C CB  . VAL A 1 151 ? -35.279 -5.744  19.146  1.00 53.81  ? 151 VAL A CB  1 
ATOM   1113 C CG1 . VAL A 1 151 ? -36.105 -7.004  19.304  1.00 55.51  ? 151 VAL A CG1 1 
ATOM   1114 C CG2 . VAL A 1 151 ? -34.043 -5.814  20.016  1.00 53.90  ? 151 VAL A CG2 1 
ATOM   1115 N N   . THR A 1 152 ? -34.894 -3.026  17.595  1.00 53.10  ? 152 THR A N   1 
ATOM   1116 C CA  . THR A 1 152 ? -34.313 -1.695  17.604  1.00 61.28  ? 152 THR A CA  1 
ATOM   1117 C C   . THR A 1 152 ? -34.583 -1.035  18.956  1.00 56.61  ? 152 THR A C   1 
ATOM   1118 O O   . THR A 1 152 ? -35.439 -1.473  19.717  1.00 54.53  ? 152 THR A O   1 
ATOM   1119 C CB  . THR A 1 152 ? -34.836 -0.855  16.427  1.00 70.44  ? 152 THR A CB  1 
ATOM   1120 O OG1 . THR A 1 152 ? -36.250 -0.687  16.550  1.00 69.03  ? 152 THR A OG1 1 
ATOM   1121 C CG2 . THR A 1 152 ? -34.536 -1.477  15.078  1.00 75.47  ? 152 THR A CG2 1 
ATOM   1122 N N   . VAL A 1 153 ? -33.833 0.029   19.241  1.00 56.32  ? 153 VAL A N   1 
ATOM   1123 C CA  . VAL A 1 153 ? -33.969 0.758   20.487  1.00 65.81  ? 153 VAL A CA  1 
ATOM   1124 C C   . VAL A 1 153 ? -33.543 2.203   20.242  1.00 65.65  ? 153 VAL A C   1 
ATOM   1125 O O   . VAL A 1 153 ? -32.513 2.437   19.614  1.00 70.26  ? 153 VAL A O   1 
ATOM   1126 C CB  . VAL A 1 153 ? -33.131 0.107   21.611  1.00 69.77  ? 153 VAL A CB  1 
ATOM   1127 C CG1 . VAL A 1 153 ? -33.058 0.979   22.862  1.00 68.56  ? 153 VAL A CG1 1 
ATOM   1128 C CG2 . VAL A 1 153 ? -33.628 -1.289  21.968  1.00 67.77  ? 153 VAL A CG2 1 
ATOM   1129 N N   . SER A 1 154 ? -34.336 3.156   20.750  1.00 65.09  ? 154 SER A N   1 
ATOM   1130 C CA  . SER A 1 154 ? -33.932 4.552   20.801  1.00 69.67  ? 154 SER A CA  1 
ATOM   1131 C C   . SER A 1 154 ? -34.160 5.093   22.211  1.00 66.79  ? 154 SER A C   1 
ATOM   1132 O O   . SER A 1 154 ? -34.698 4.397   23.060  1.00 64.29  ? 154 SER A O   1 
ATOM   1133 C CB  . SER A 1 154 ? -34.657 5.374   19.767  1.00 73.90  ? 154 SER A CB  1 
ATOM   1134 O OG  . SER A 1 154 ? -36.035 5.494   20.089  1.00 79.79  ? 154 SER A OG  1 
ATOM   1135 N N   . TRP A 1 155 ? -33.705 6.326   22.456  1.00 67.65  ? 155 TRP A N   1 
ATOM   1136 C CA  . TRP A 1 155 ? -33.877 6.980   23.743  1.00 68.96  ? 155 TRP A CA  1 
ATOM   1137 C C   . TRP A 1 155 ? -34.516 8.356   23.552  1.00 68.85  ? 155 TRP A C   1 
ATOM   1138 O O   . TRP A 1 155 ? -33.927 9.237   22.911  1.00 54.16  ? 155 TRP A O   1 
ATOM   1139 C CB  . TRP A 1 155 ? -32.540 7.071   24.486  1.00 69.75  ? 155 TRP A CB  1 
ATOM   1140 C CG  . TRP A 1 155 ? -32.101 5.771   25.086  1.00 74.06  ? 155 TRP A CG  1 
ATOM   1141 C CD1 . TRP A 1 155 ? -31.271 4.847   24.523  1.00 72.25  ? 155 TRP A CD1 1 
ATOM   1142 C CD2 . TRP A 1 155 ? -32.435 5.265   26.391  1.00 74.53  ? 155 TRP A CD2 1 
ATOM   1143 N NE1 . TRP A 1 155 ? -31.084 3.793   25.375  1.00 68.07  ? 155 TRP A NE1 1 
ATOM   1144 C CE2 . TRP A 1 155 ? -31.779 4.024   26.531  1.00 71.37  ? 155 TRP A CE2 1 
ATOM   1145 C CE3 . TRP A 1 155 ? -33.217 5.736   27.451  1.00 76.17  ? 155 TRP A CE3 1 
ATOM   1146 C CZ2 . TRP A 1 155 ? -31.890 3.249   27.683  1.00 75.70  ? 155 TRP A CZ2 1 
ATOM   1147 C CZ3 . TRP A 1 155 ? -33.324 4.971   28.590  1.00 80.48  ? 155 TRP A CZ3 1 
ATOM   1148 C CH2 . TRP A 1 155 ? -32.667 3.744   28.703  1.00 78.88  ? 155 TRP A CH2 1 
ATOM   1149 N N   . ASN A 1 156 ? -35.729 8.490   24.124  1.00 70.18  ? 156 ASN A N   1 
ATOM   1150 C CA  . ASN A 1 156 ? -36.533 9.708   24.133  1.00 67.79  ? 156 ASN A CA  1 
ATOM   1151 C C   . ASN A 1 156 ? -36.978 10.016  22.705  1.00 67.65  ? 156 ASN A C   1 
ATOM   1152 O O   . ASN A 1 156 ? -36.739 11.112  22.195  1.00 67.60  ? 156 ASN A O   1 
ATOM   1153 C CB  . ASN A 1 156 ? -35.810 10.857  24.852  1.00 63.89  ? 156 ASN A CB  1 
ATOM   1154 C CG  . ASN A 1 156 ? -35.624 10.587  26.334  1.00 63.23  ? 156 ASN A CG  1 
ATOM   1155 O OD1 . ASN A 1 156 ? -36.358 9.795   26.924  1.00 67.98  ? 156 ASN A OD1 1 
ATOM   1156 N ND2 . ASN A 1 156 ? -34.656 11.242  26.955  1.00 61.41  ? 156 ASN A ND2 1 
ATOM   1157 N N   . SER A 1 157 ? -37.629 9.015   22.090  1.00 71.36  ? 157 SER A N   1 
ATOM   1158 C CA  . SER A 1 157 ? -38.075 9.055   20.704  1.00 73.69  ? 157 SER A CA  1 
ATOM   1159 C C   . SER A 1 157 ? -36.950 9.488   19.753  1.00 77.62  ? 157 SER A C   1 
ATOM   1160 O O   . SER A 1 157 ? -37.204 10.077  18.706  1.00 75.24  ? 157 SER A O   1 
ATOM   1161 C CB  . SER A 1 157 ? -39.292 9.935   20.581  1.00 71.29  ? 157 SER A CB  1 
ATOM   1162 O OG  . SER A 1 157 ? -40.377 9.396   21.316  1.00 70.42  ? 157 SER A OG  1 
ATOM   1163 N N   . GLY A 1 158 ? -35.700 9.163   20.100  1.00 78.30  ? 158 GLY A N   1 
ATOM   1164 C CA  . GLY A 1 158 ? -34.549 9.617   19.339  1.00 72.73  ? 158 GLY A CA  1 
ATOM   1165 C C   . GLY A 1 158 ? -34.295 11.112  19.509  1.00 72.05  ? 158 GLY A C   1 
ATOM   1166 O O   . GLY A 1 158 ? -34.171 11.827  18.521  1.00 83.26  ? 158 GLY A O   1 
ATOM   1167 N N   . ALA A 1 159 ? -34.245 11.584  20.761  1.00 65.15  ? 159 ALA A N   1 
ATOM   1168 C CA  . ALA A 1 159 ? -33.727 12.911  21.071  1.00 63.03  ? 159 ALA A CA  1 
ATOM   1169 C C   . ALA A 1 159 ? -32.377 12.759  21.766  1.00 65.20  ? 159 ALA A C   1 
ATOM   1170 O O   . ALA A 1 159 ? -31.428 13.495  21.489  1.00 61.37  ? 159 ALA A O   1 
ATOM   1171 C CB  . ALA A 1 159 ? -34.701 13.665  21.940  1.00 64.60  ? 159 ALA A CB  1 
ATOM   1172 N N   . LEU A 1 160 ? -32.337 11.805  22.702  1.00 63.88  ? 160 LEU A N   1 
ATOM   1173 C CA  . LEU A 1 160 ? -31.106 11.288  23.268  1.00 65.55  ? 160 LEU A CA  1 
ATOM   1174 C C   . LEU A 1 160 ? -30.590 10.173  22.357  1.00 68.75  ? 160 LEU A C   1 
ATOM   1175 O O   . LEU A 1 160 ? -31.118 9.060   22.339  1.00 65.44  ? 160 LEU A O   1 
ATOM   1176 C CB  . LEU A 1 160 ? -31.395 10.786  24.690  1.00 64.49  ? 160 LEU A CB  1 
ATOM   1177 C CG  . LEU A 1 160 ? -30.207 10.260  25.495  1.00 62.26  ? 160 LEU A CG  1 
ATOM   1178 C CD1 . LEU A 1 160 ? -29.213 11.371  25.824  1.00 61.54  ? 160 LEU A CD1 1 
ATOM   1179 C CD2 . LEU A 1 160 ? -30.695 9.585   26.770  1.00 61.48  ? 160 LEU A CD2 1 
ATOM   1180 N N   . THR A 1 161 ? -29.580 10.515  21.556  1.00 68.47  ? 161 THR A N   1 
ATOM   1181 C CA  . THR A 1 161 ? -28.780 9.534   20.846  1.00 67.19  ? 161 THR A CA  1 
ATOM   1182 C C   . THR A 1 161 ? -27.352 9.632   21.366  1.00 66.32  ? 161 THR A C   1 
ATOM   1183 O O   . THR A 1 161 ? -26.667 8.623   21.510  1.00 65.24  ? 161 THR A O   1 
ATOM   1184 C CB  . THR A 1 161 ? -28.886 9.743   19.331  1.00 70.40  ? 161 THR A CB  1 
ATOM   1185 O OG1 . THR A 1 161 ? -28.636 11.129  19.080  1.00 69.30  ? 161 THR A OG1 1 
ATOM   1186 C CG2 . THR A 1 161 ? -30.231 9.338   18.769  1.00 66.29  ? 161 THR A CG2 1 
ATOM   1187 N N   . SER A 1 162 ? -26.915 10.857  21.669  1.00 65.35  ? 162 SER A N   1 
ATOM   1188 C CA  . SER A 1 162 ? -25.619 11.049  22.289  1.00 68.27  ? 162 SER A CA  1 
ATOM   1189 C C   . SER A 1 162 ? -25.513 10.155  23.528  1.00 74.80  ? 162 SER A C   1 
ATOM   1190 O O   . SER A 1 162 ? -26.481 10.018  24.279  1.00 78.96  ? 162 SER A O   1 
ATOM   1191 C CB  . SER A 1 162 ? -25.394 12.497  22.605  1.00 68.52  ? 162 SER A CB  1 
ATOM   1192 O OG  . SER A 1 162 ? -24.033 12.739  22.919  1.00 69.52  ? 162 SER A OG  1 
ATOM   1193 N N   . GLY A 1 163 ? -24.355 9.488   23.675  1.00 73.79  ? 163 GLY A N   1 
ATOM   1194 C CA  . GLY A 1 163 ? -24.046 8.636   24.815  1.00 65.25  ? 163 GLY A CA  1 
ATOM   1195 C C   . GLY A 1 163 ? -24.700 7.250   24.776  1.00 61.05  ? 163 GLY A C   1 
ATOM   1196 O O   . GLY A 1 163 ? -24.475 6.443   25.673  1.00 58.70  ? 163 GLY A O   1 
ATOM   1197 N N   . VAL A 1 164 ? -25.522 6.954   23.764  1.00 60.66  ? 164 VAL A N   1 
ATOM   1198 C CA  . VAL A 1 164 ? -26.264 5.703   23.763  1.00 60.59  ? 164 VAL A CA  1 
ATOM   1199 C C   . VAL A 1 164 ? -25.356 4.570   23.293  1.00 63.64  ? 164 VAL A C   1 
ATOM   1200 O O   . VAL A 1 164 ? -24.525 4.752   22.405  1.00 62.46  ? 164 VAL A O   1 
ATOM   1201 C CB  . VAL A 1 164 ? -27.527 5.775   22.892  1.00 58.40  ? 164 VAL A CB  1 
ATOM   1202 C CG1 . VAL A 1 164 ? -28.262 4.443   22.862  1.00 58.17  ? 164 VAL A CG1 1 
ATOM   1203 C CG2 . VAL A 1 164 ? -28.453 6.886   23.351  1.00 61.56  ? 164 VAL A CG2 1 
ATOM   1204 N N   . HIS A 1 165 ? -25.567 3.398   23.900  1.00 62.85  ? 165 HIS A N   1 
ATOM   1205 C CA  . HIS A 1 165 ? -24.882 2.165   23.554  1.00 58.95  ? 165 HIS A CA  1 
ATOM   1206 C C   . HIS A 1 165 ? -25.901 1.029   23.595  1.00 55.49  ? 165 HIS A C   1 
ATOM   1207 O O   . HIS A 1 165 ? -26.296 0.591   24.671  1.00 57.64  ? 165 HIS A O   1 
ATOM   1208 C CB  . HIS A 1 165 ? -23.761 1.854   24.554  1.00 56.39  ? 165 HIS A CB  1 
ATOM   1209 C CG  . HIS A 1 165 ? -22.601 2.793   24.558  1.00 58.58  ? 165 HIS A CG  1 
ATOM   1210 N ND1 . HIS A 1 165 ? -22.289 3.690   23.560  1.00 64.06  ? 165 HIS A ND1 1 
ATOM   1211 C CD2 . HIS A 1 165 ? -21.647 2.938   25.496  1.00 57.26  ? 165 HIS A CD2 1 
ATOM   1212 C CE1 . HIS A 1 165 ? -21.187 4.358   23.898  1.00 68.09  ? 165 HIS A CE1 1 
ATOM   1213 N NE2 . HIS A 1 165 ? -20.783 3.920   25.078  1.00 59.62  ? 165 HIS A NE2 1 
ATOM   1214 N N   . THR A 1 166 ? -26.343 0.571   22.420  1.00 52.55  ? 166 THR A N   1 
ATOM   1215 C CA  . THR A 1 166 ? -27.166 -0.619  22.327  1.00 52.40  ? 166 THR A CA  1 
ATOM   1216 C C   . THR A 1 166 ? -26.264 -1.812  22.021  1.00 55.99  ? 166 THR A C   1 
ATOM   1217 O O   . THR A 1 166 ? -25.344 -1.697  21.216  1.00 52.02  ? 166 THR A O   1 
ATOM   1218 C CB  . THR A 1 166 ? -28.261 -0.411  21.284  1.00 53.04  ? 166 THR A CB  1 
ATOM   1219 O OG1 . THR A 1 166 ? -28.926 0.786   21.687  1.00 58.27  ? 166 THR A OG1 1 
ATOM   1220 C CG2 . THR A 1 166 ? -29.206 -1.589  21.174  1.00 49.59  ? 166 THR A CG2 1 
ATOM   1221 N N   . PHE A 1 167 ? -26.535 -2.944  22.690  1.00 58.69  ? 167 PHE A N   1 
ATOM   1222 C CA  . PHE A 1 167 ? -25.618 -4.072  22.732  1.00 52.85  ? 167 PHE A CA  1 
ATOM   1223 C C   . PHE A 1 167 ? -26.080 -5.130  21.741  1.00 49.78  ? 167 PHE A C   1 
ATOM   1224 O O   . PHE A 1 167 ? -27.270 -5.264  21.500  1.00 46.11  ? 167 PHE A O   1 
ATOM   1225 C CB  . PHE A 1 167 ? -25.502 -4.654  24.146  1.00 52.49  ? 167 PHE A CB  1 
ATOM   1226 C CG  . PHE A 1 167 ? -24.619 -3.844  25.064  1.00 55.21  ? 167 PHE A CG  1 
ATOM   1227 C CD1 . PHE A 1 167 ? -23.250 -4.057  25.095  1.00 54.05  ? 167 PHE A CD1 1 
ATOM   1228 C CD2 . PHE A 1 167 ? -25.144 -2.827  25.849  1.00 55.01  ? 167 PHE A CD2 1 
ATOM   1229 C CE1 . PHE A 1 167 ? -22.429 -3.289  25.907  1.00 59.18  ? 167 PHE A CE1 1 
ATOM   1230 C CE2 . PHE A 1 167 ? -24.319 -2.052  26.649  1.00 57.23  ? 167 PHE A CE2 1 
ATOM   1231 C CZ  . PHE A 1 167 ? -22.963 -2.288  26.685  1.00 57.70  ? 167 PHE A CZ  1 
ATOM   1232 N N   . PRO A 1 168 ? -25.147 -5.885  21.113  1.00 49.11  ? 168 PRO A N   1 
ATOM   1233 C CA  . PRO A 1 168 ? -25.510 -7.057  20.327  1.00 45.60  ? 168 PRO A CA  1 
ATOM   1234 C C   . PRO A 1 168 ? -26.290 -8.058  21.161  1.00 41.31  ? 168 PRO A C   1 
ATOM   1235 O O   . PRO A 1 168 ? -25.918 -8.345  22.296  1.00 45.05  ? 168 PRO A O   1 
ATOM   1236 C CB  . PRO A 1 168 ? -24.163 -7.684  19.933  1.00 47.05  ? 168 PRO A CB  1 
ATOM   1237 C CG  . PRO A 1 168 ? -23.185 -6.539  19.991  1.00 46.21  ? 168 PRO A CG  1 
ATOM   1238 C CD  . PRO A 1 168 ? -23.697 -5.642  21.102  1.00 47.98  ? 168 PRO A CD  1 
ATOM   1239 N N   . ALA A 1 169 ? -27.347 -8.589  20.557  1.00 41.98  ? 169 ALA A N   1 
ATOM   1240 C CA  . ALA A 1 169 ? -28.113 -9.685  21.110  1.00 44.62  ? 169 ALA A CA  1 
ATOM   1241 C C   . ALA A 1 169 ? -27.197 -10.841 21.500  1.00 46.13  ? 169 ALA A C   1 
ATOM   1242 O O   . ALA A 1 169 ? -26.119 -11.006 20.946  1.00 49.50  ? 169 ALA A O   1 
ATOM   1243 C CB  . ALA A 1 169 ? -29.130 -10.127 20.091  1.00 47.92  ? 169 ALA A CB  1 
ATOM   1244 N N   . VAL A 1 170 ? -27.635 -11.625 22.483  1.00 45.14  ? 170 VAL A N   1 
ATOM   1245 C CA  . VAL A 1 170 ? -27.009 -12.897 22.758  1.00 47.19  ? 170 VAL A CA  1 
ATOM   1246 C C   . VAL A 1 170 ? -28.093 -13.970 22.684  1.00 49.79  ? 170 VAL A C   1 
ATOM   1247 O O   . VAL A 1 170 ? -29.244 -13.764 23.085  1.00 41.90  ? 170 VAL A O   1 
ATOM   1248 C CB  . VAL A 1 170 ? -26.262 -12.889 24.108  1.00 58.28  ? 170 VAL A CB  1 
ATOM   1249 C CG1 . VAL A 1 170 ? -25.185 -11.813 24.138  1.00 59.03  ? 170 VAL A CG1 1 
ATOM   1250 C CG2 . VAL A 1 170 ? -27.193 -12.737 25.305  1.00 60.42  ? 170 VAL A CG2 1 
ATOM   1251 N N   . LEU A 1 171 ? -27.721 -15.105 22.097  1.00 45.56  ? 171 LEU A N   1 
ATOM   1252 C CA  . LEU A 1 171 ? -28.581 -16.264 22.118  1.00 45.65  ? 171 LEU A CA  1 
ATOM   1253 C C   . LEU A 1 171 ? -28.369 -16.968 23.455  1.00 48.47  ? 171 LEU A C   1 
ATOM   1254 O O   . LEU A 1 171 ? -27.256 -17.361 23.782  1.00 46.31  ? 171 LEU A O   1 
ATOM   1255 C CB  . LEU A 1 171 ? -28.240 -17.146 20.916  1.00 42.65  ? 171 LEU A CB  1 
ATOM   1256 C CG  . LEU A 1 171 ? -29.141 -18.363 20.699  1.00 47.81  ? 171 LEU A CG  1 
ATOM   1257 C CD1 . LEU A 1 171 ? -30.594 -17.956 20.459  1.00 48.14  ? 171 LEU A CD1 1 
ATOM   1258 C CD2 . LEU A 1 171 ? -28.625 -19.204 19.533  1.00 47.77  ? 171 LEU A CD2 1 
ATOM   1259 N N   . GLN A 1 172 ? -29.449 -17.076 24.233  1.00 52.06  ? 172 GLN A N   1 
ATOM   1260 C CA  . GLN A 1 172 ? -29.442 -17.779 25.504  1.00 54.06  ? 172 GLN A CA  1 
ATOM   1261 C C   . GLN A 1 172 ? -29.655 -19.257 25.192  1.00 56.15  ? 172 GLN A C   1 
ATOM   1262 O O   . GLN A 1 172 ? -30.018 -19.598 24.070  1.00 57.06  ? 172 GLN A O   1 
ATOM   1263 C CB  . GLN A 1 172 ? -30.529 -17.196 26.415  1.00 55.34  ? 172 GLN A CB  1 
ATOM   1264 C CG  . GLN A 1 172 ? -30.422 -15.679 26.599  1.00 54.46  ? 172 GLN A CG  1 
ATOM   1265 C CD  . GLN A 1 172 ? -31.640 -15.031 27.220  1.00 57.08  ? 172 GLN A CD  1 
ATOM   1266 O OE1 . GLN A 1 172 ? -31.552 -14.336 28.230  1.00 63.49  ? 172 GLN A OE1 1 
ATOM   1267 N NE2 . GLN A 1 172 ? -32.795 -15.216 26.604  1.00 58.81  ? 172 GLN A NE2 1 
ATOM   1268 N N   . SER A 1 173 ? -29.448 -20.133 26.181  1.00 57.97  ? 173 SER A N   1 
ATOM   1269 C CA  . SER A 1 173 ? -29.582 -21.564 25.950  1.00 56.62  ? 173 SER A CA  1 
ATOM   1270 C C   . SER A 1 173 ? -31.054 -21.987 25.953  1.00 54.59  ? 173 SER A C   1 
ATOM   1271 O O   . SER A 1 173 ? -31.354 -23.145 25.702  1.00 56.46  ? 173 SER A O   1 
ATOM   1272 C CB  . SER A 1 173 ? -28.738 -22.365 26.920  1.00 56.62  ? 173 SER A CB  1 
ATOM   1273 O OG  . SER A 1 173 ? -28.984 -21.981 28.260  1.00 54.34  ? 173 SER A OG  1 
ATOM   1274 N N   . SER A 1 174 ? -31.973 -21.038 26.186  1.00 61.14  ? 174 SER A N   1 
ATOM   1275 C CA  . SER A 1 174 ? -33.392 -21.224 25.907  1.00 59.83  ? 174 SER A CA  1 
ATOM   1276 C C   . SER A 1 174 ? -33.674 -21.259 24.401  1.00 63.57  ? 174 SER A C   1 
ATOM   1277 O O   . SER A 1 174 ? -34.744 -21.709 23.980  1.00 64.89  ? 174 SER A O   1 
ATOM   1278 C CB  . SER A 1 174 ? -34.204 -20.134 26.559  1.00 59.34  ? 174 SER A CB  1 
ATOM   1279 O OG  . SER A 1 174 ? -33.713 -18.854 26.190  1.00 61.81  ? 174 SER A OG  1 
ATOM   1280 N N   . GLY A 1 175 ? -32.734 -20.751 23.592  1.00 55.10  ? 175 GLY A N   1 
ATOM   1281 C CA  . GLY A 1 175 ? -32.979 -20.547 22.172  1.00 54.09  ? 175 GLY A CA  1 
ATOM   1282 C C   . GLY A 1 175 ? -33.819 -19.295 21.929  1.00 50.19  ? 175 GLY A C   1 
ATOM   1283 O O   . GLY A 1 175 ? -34.584 -19.227 20.970  1.00 47.26  ? 175 GLY A O   1 
ATOM   1284 N N   . LEU A 1 176 ? -33.692 -18.322 22.840  1.00 45.94  ? 176 LEU A N   1 
ATOM   1285 C CA  . LEU A 1 176 ? -34.345 -17.032 22.703  1.00 42.17  ? 176 LEU A CA  1 
ATOM   1286 C C   . LEU A 1 176 ? -33.258 -15.995 22.891  1.00 34.90  ? 176 LEU A C   1 
ATOM   1287 O O   . LEU A 1 176 ? -32.313 -16.242 23.623  1.00 34.68  ? 176 LEU A O   1 
ATOM   1288 C CB  . LEU A 1 176 ? -35.438 -16.840 23.762  1.00 45.62  ? 176 LEU A CB  1 
ATOM   1289 C CG  . LEU A 1 176 ? -36.623 -17.807 23.747  1.00 47.15  ? 176 LEU A CG  1 
ATOM   1290 C CD1 . LEU A 1 176 ? -37.598 -17.459 24.865  1.00 44.92  ? 176 LEU A CD1 1 
ATOM   1291 C CD2 . LEU A 1 176 ? -37.339 -17.782 22.410  1.00 49.93  ? 176 LEU A CD2 1 
ATOM   1292 N N   . TYR A 1 177 ? -33.437 -14.838 22.265  1.00 35.51  ? 177 TYR A N   1 
ATOM   1293 C CA  . TYR A 1 177 ? -32.443 -13.786 22.298  1.00 37.73  ? 177 TYR A CA  1 
ATOM   1294 C C   . TYR A 1 177 ? -32.715 -12.837 23.453  1.00 41.04  ? 177 TYR A C   1 
ATOM   1295 O O   . TYR A 1 177 ? -33.778 -12.865 24.069  1.00 42.57  ? 177 TYR A O   1 
ATOM   1296 C CB  . TYR A 1 177 ? -32.408 -13.026 20.971  1.00 39.96  ? 177 TYR A CB  1 
ATOM   1297 C CG  . TYR A 1 177 ? -31.811 -13.816 19.832  1.00 42.58  ? 177 TYR A CG  1 
ATOM   1298 C CD1 . TYR A 1 177 ? -32.588 -14.665 19.065  1.00 44.86  ? 177 TYR A CD1 1 
ATOM   1299 C CD2 . TYR A 1 177 ? -30.453 -13.752 19.550  1.00 45.89  ? 177 TYR A CD2 1 
ATOM   1300 C CE1 . TYR A 1 177 ? -32.044 -15.410 18.027  1.00 51.16  ? 177 TYR A CE1 1 
ATOM   1301 C CE2 . TYR A 1 177 ? -29.894 -14.491 18.518  1.00 47.76  ? 177 TYR A CE2 1 
ATOM   1302 C CZ  . TYR A 1 177 ? -30.690 -15.326 17.756  1.00 47.72  ? 177 TYR A CZ  1 
ATOM   1303 O OH  . TYR A 1 177 ? -30.153 -16.064 16.733  1.00 55.14  ? 177 TYR A OH  1 
ATOM   1304 N N   . SER A 1 178 ? -31.724 -11.978 23.694  1.00 42.01  ? 178 SER A N   1 
ATOM   1305 C CA  . SER A 1 178 ? -31.743 -11.009 24.762  1.00 43.13  ? 178 SER A CA  1 
ATOM   1306 C C   . SER A 1 178 ? -30.685 -9.955  24.466  1.00 44.70  ? 178 SER A C   1 
ATOM   1307 O O   . SER A 1 178 ? -29.658 -10.266 23.876  1.00 50.69  ? 178 SER A O   1 
ATOM   1308 C CB  . SER A 1 178 ? -31.501 -11.711 26.069  1.00 47.61  ? 178 SER A CB  1 
ATOM   1309 O OG  . SER A 1 178 ? -31.295 -10.781 27.109  1.00 51.59  ? 178 SER A OG  1 
ATOM   1310 N N   . LEU A 1 179 ? -30.944 -8.708  24.851  1.00 47.15  ? 179 LEU A N   1 
ATOM   1311 C CA  . LEU A 1 179 ? -29.949 -7.661  24.737  1.00 48.89  ? 179 LEU A CA  1 
ATOM   1312 C C   . LEU A 1 179 ? -30.280 -6.521  25.688  1.00 48.16  ? 179 LEU A C   1 
ATOM   1313 O O   . LEU A 1 179 ? -31.427 -6.367  26.100  1.00 46.02  ? 179 LEU A O   1 
ATOM   1314 C CB  . LEU A 1 179 ? -29.901 -7.149  23.295  1.00 57.23  ? 179 LEU A CB  1 
ATOM   1315 C CG  . LEU A 1 179 ? -31.078 -6.290  22.838  1.00 57.53  ? 179 LEU A CG  1 
ATOM   1316 C CD1 . LEU A 1 179 ? -30.904 -4.832  23.237  1.00 59.34  ? 179 LEU A CD1 1 
ATOM   1317 C CD2 . LEU A 1 179 ? -31.238 -6.383  21.335  1.00 57.88  ? 179 LEU A CD2 1 
ATOM   1318 N N   . SER A 1 180 ? -29.262 -5.699  25.957  1.00 49.11  ? 180 SER A N   1 
ATOM   1319 C CA  . SER A 1 180 ? -29.401 -4.520  26.789  1.00 56.49  ? 180 SER A CA  1 
ATOM   1320 C C   . SER A 1 180 ? -29.071 -3.271  25.981  1.00 58.15  ? 180 SER A C   1 
ATOM   1321 O O   . SER A 1 180 ? -28.204 -3.301  25.111  1.00 63.20  ? 180 SER A O   1 
ATOM   1322 C CB  . SER A 1 180 ? -28.513 -4.634  27.996  1.00 60.38  ? 180 SER A CB  1 
ATOM   1323 O OG  . SER A 1 180 ? -28.763 -5.857  28.676  1.00 70.39  ? 180 SER A OG  1 
ATOM   1324 N N   . SER A 1 181 ? -29.770 -2.176  26.288  1.00 55.70  ? 181 SER A N   1 
ATOM   1325 C CA  . SER A 1 181 ? -29.393 -0.859  25.809  1.00 53.68  ? 181 SER A CA  1 
ATOM   1326 C C   . SER A 1 181 ? -29.226 0.087   26.990  1.00 53.87  ? 181 SER A C   1 
ATOM   1327 O O   . SER A 1 181 ? -30.024 0.059   27.910  1.00 56.82  ? 181 SER A O   1 
ATOM   1328 C CB  . SER A 1 181 ? -30.416 -0.325  24.877  1.00 56.12  ? 181 SER A CB  1 
ATOM   1329 O OG  . SER A 1 181 ? -30.082 1.009   24.537  1.00 61.75  ? 181 SER A OG  1 
ATOM   1330 N N   . VAL A 1 182 ? -28.209 0.947   26.946  1.00 56.86  ? 182 VAL A N   1 
ATOM   1331 C CA  . VAL A 1 182 ? -27.899 1.794   28.081  1.00 59.66  ? 182 VAL A CA  1 
ATOM   1332 C C   . VAL A 1 182 ? -27.499 3.181   27.584  1.00 67.92  ? 182 VAL A C   1 
ATOM   1333 O O   . VAL A 1 182 ? -27.345 3.402   26.383  1.00 69.54  ? 182 VAL A O   1 
ATOM   1334 C CB  . VAL A 1 182 ? -26.807 1.156   28.965  1.00 61.75  ? 182 VAL A CB  1 
ATOM   1335 C CG1 . VAL A 1 182 ? -27.130 -0.293  29.304  1.00 63.02  ? 182 VAL A CG1 1 
ATOM   1336 C CG2 . VAL A 1 182 ? -25.414 1.255   28.355  1.00 66.56  ? 182 VAL A CG2 1 
ATOM   1337 N N   . VAL A 1 183 ? -27.345 4.111   28.536  1.00 71.30  ? 183 VAL A N   1 
ATOM   1338 C CA  . VAL A 1 183 ? -26.874 5.457   28.246  1.00 69.44  ? 183 VAL A CA  1 
ATOM   1339 C C   . VAL A 1 183 ? -26.405 6.101   29.550  1.00 69.41  ? 183 VAL A C   1 
ATOM   1340 O O   . VAL A 1 183 ? -26.996 5.890   30.608  1.00 68.64  ? 183 VAL A O   1 
ATOM   1341 C CB  . VAL A 1 183 ? -27.947 6.310   27.533  1.00 67.78  ? 183 VAL A CB  1 
ATOM   1342 C CG1 . VAL A 1 183 ? -29.322 6.160   28.172  1.00 66.77  ? 183 VAL A CG1 1 
ATOM   1343 C CG2 . VAL A 1 183 ? -27.539 7.776   27.436  1.00 62.31  ? 183 VAL A CG2 1 
ATOM   1344 N N   . THR A 1 184 ? -25.318 6.871   29.457  1.00 66.12  ? 184 THR A N   1 
ATOM   1345 C CA  . THR A 1 184 ? -24.787 7.573   30.606  1.00 70.80  ? 184 THR A CA  1 
ATOM   1346 C C   . THR A 1 184 ? -25.179 9.046   30.486  1.00 76.25  ? 184 THR A C   1 
ATOM   1347 O O   . THR A 1 184 ? -25.103 9.625   29.398  1.00 64.06  ? 184 THR A O   1 
ATOM   1348 C CB  . THR A 1 184 ? -23.281 7.323   30.765  1.00 72.87  ? 184 THR A CB  1 
ATOM   1349 O OG1 . THR A 1 184 ? -22.583 8.032   29.741  1.00 71.18  ? 184 THR A OG1 1 
ATOM   1350 C CG2 . THR A 1 184 ? -22.918 5.854   30.729  1.00 73.36  ? 184 THR A CG2 1 
ATOM   1351 N N   . VAL A 1 185 ? -25.589 9.613   31.637  1.00 83.21  ? 185 VAL A N   1 
ATOM   1352 C CA  . VAL A 1 185 ? -26.173 10.944  31.756  1.00 78.79  ? 185 VAL A CA  1 
ATOM   1353 C C   . VAL A 1 185 ? -25.551 11.652  32.967  1.00 75.97  ? 185 VAL A C   1 
ATOM   1354 O O   . VAL A 1 185 ? -24.949 11.002  33.825  1.00 63.26  ? 185 VAL A O   1 
ATOM   1355 C CB  . VAL A 1 185 ? -27.714 10.865  31.886  1.00 69.32  ? 185 VAL A CB  1 
ATOM   1356 C CG1 . VAL A 1 185 ? -28.376 10.377  30.608  1.00 65.02  ? 185 VAL A CG1 1 
ATOM   1357 C CG2 . VAL A 1 185 ? -28.151 9.996   33.055  1.00 66.00  ? 185 VAL A CG2 1 
ATOM   1358 N N   . PRO A 1 186 ? -25.658 13.001  33.084  1.00 80.85  ? 186 PRO A N   1 
ATOM   1359 C CA  . PRO A 1 186 ? -25.360 13.688  34.344  1.00 79.57  ? 186 PRO A CA  1 
ATOM   1360 C C   . PRO A 1 186 ? -26.271 13.212  35.477  1.00 79.39  ? 186 PRO A C   1 
ATOM   1361 O O   . PRO A 1 186 ? -27.465 12.968  35.269  1.00 76.57  ? 186 PRO A O   1 
ATOM   1362 C CB  . PRO A 1 186 ? -25.570 15.179  34.027  1.00 75.20  ? 186 PRO A CB  1 
ATOM   1363 C CG  . PRO A 1 186 ? -25.443 15.262  32.515  1.00 75.22  ? 186 PRO A CG  1 
ATOM   1364 C CD  . PRO A 1 186 ? -26.006 13.948  32.009  1.00 81.81  ? 186 PRO A CD  1 
ATOM   1365 N N   . SER A 1 187 ? -25.681 13.075  36.674  1.00 79.38  ? 187 SER A N   1 
ATOM   1366 C CA  . SER A 1 187 ? -26.372 12.530  37.834  1.00 81.70  ? 187 SER A CA  1 
ATOM   1367 C C   . SER A 1 187 ? -27.135 13.626  38.578  1.00 83.33  ? 187 SER A C   1 
ATOM   1368 O O   . SER A 1 187 ? -27.778 13.347  39.586  1.00 89.22  ? 187 SER A O   1 
ATOM   1369 C CB  . SER A 1 187 ? -25.415 11.787  38.741  1.00 79.45  ? 187 SER A CB  1 
ATOM   1370 O OG  . SER A 1 187 ? -24.228 12.534  38.963  1.00 80.10  ? 187 SER A OG  1 
ATOM   1371 N N   . SER A 1 188 ? -27.059 14.869  38.075  1.00 85.72  ? 188 SER A N   1 
ATOM   1372 C CA  . SER A 1 188 ? -27.957 15.938  38.489  1.00 82.22  ? 188 SER A CA  1 
ATOM   1373 C C   . SER A 1 188 ? -29.299 15.826  37.752  1.00 78.74  ? 188 SER A C   1 
ATOM   1374 O O   . SER A 1 188 ? -30.357 16.094  38.313  1.00 73.70  ? 188 SER A O   1 
ATOM   1375 C CB  . SER A 1 188 ? -27.302 17.292  38.280  1.00 77.87  ? 188 SER A CB  1 
ATOM   1376 O OG  . SER A 1 188 ? -27.053 17.545  36.904  1.00 73.55  ? 188 SER A OG  1 
ATOM   1377 N N   . SER A 1 189 ? -29.256 15.380  36.495  1.00 81.91  ? 189 SER A N   1 
ATOM   1378 C CA  . SER A 1 189 ? -30.412 15.386  35.612  1.00 84.97  ? 189 SER A CA  1 
ATOM   1379 C C   . SER A 1 189 ? -31.528 14.468  36.109  1.00 80.14  ? 189 SER A C   1 
ATOM   1380 O O   . SER A 1 189 ? -32.644 14.550  35.604  1.00 77.91  ? 189 SER A O   1 
ATOM   1381 C CB  . SER A 1 189 ? -30.009 14.969  34.212  1.00 90.61  ? 189 SER A CB  1 
ATOM   1382 O OG  . SER A 1 189 ? -28.859 15.671  33.765  1.00 94.47  ? 189 SER A OG  1 
ATOM   1383 N N   . LEU A 1 190 ? -31.219 13.578  37.063  1.00 78.43  ? 190 LEU A N   1 
ATOM   1384 C CA  . LEU A 1 190 ? -32.006 12.368  37.275  1.00 84.98  ? 190 LEU A CA  1 
ATOM   1385 C C   . LEU A 1 190 ? -33.420 12.694  37.764  1.00 84.64  ? 190 LEU A C   1 
ATOM   1386 O O   . LEU A 1 190 ? -34.390 12.174  37.219  1.00 80.24  ? 190 LEU A O   1 
ATOM   1387 C CB  . LEU A 1 190 ? -31.269 11.453  38.262  1.00 83.43  ? 190 LEU A CB  1 
ATOM   1388 C CG  . LEU A 1 190 ? -29.871 10.990  37.842  1.00 86.35  ? 190 LEU A CG  1 
ATOM   1389 C CD1 . LEU A 1 190 ? -29.354 9.900   38.773  1.00 83.80  ? 190 LEU A CD1 1 
ATOM   1390 C CD2 . LEU A 1 190 ? -29.851 10.496  36.398  1.00 87.40  ? 190 LEU A CD2 1 
ATOM   1391 N N   . GLY A 1 191 ? -33.526 13.540  38.797  1.00 85.16  ? 191 GLY A N   1 
ATOM   1392 C CA  . GLY A 1 191 ? -34.811 13.988  39.311  1.00 82.82  ? 191 GLY A CA  1 
ATOM   1393 C C   . GLY A 1 191 ? -35.578 14.839  38.298  1.00 85.61  ? 191 GLY A C   1 
ATOM   1394 O O   . GLY A 1 191 ? -36.770 14.626  38.091  1.00 82.44  ? 191 GLY A O   1 
ATOM   1395 N N   . THR A 1 192 ? -34.875 15.786  37.655  1.00 89.83  ? 192 THR A N   1 
ATOM   1396 C CA  . THR A 1 192 ? -35.495 16.757  36.761  1.00 88.92  ? 192 THR A CA  1 
ATOM   1397 C C   . THR A 1 192 ? -35.956 16.090  35.459  1.00 84.76  ? 192 THR A C   1 
ATOM   1398 O O   . THR A 1 192 ? -37.120 16.218  35.084  1.00 72.68  ? 192 THR A O   1 
ATOM   1399 C CB  . THR A 1 192 ? -34.556 17.951  36.506  1.00 88.34  ? 192 THR A CB  1 
ATOM   1400 O OG1 . THR A 1 192 ? -33.308 17.482  35.994  1.00 88.41  ? 192 THR A OG1 1 
ATOM   1401 C CG2 . THR A 1 192 ? -34.287 18.772  37.751  1.00 86.57  ? 192 THR A CG2 1 
ATOM   1402 N N   . GLN A 1 193 ? -35.045 15.362  34.790  1.00 85.91  ? 193 GLN A N   1 
ATOM   1403 C CA  . GLN A 1 193 ? -35.222 14.941  33.403  1.00 81.28  ? 193 GLN A CA  1 
ATOM   1404 C C   . GLN A 1 193 ? -35.786 13.521  33.340  1.00 75.24  ? 193 GLN A C   1 
ATOM   1405 O O   . GLN A 1 193 ? -35.372 12.654  34.105  1.00 73.74  ? 193 GLN A O   1 
ATOM   1406 C CB  . GLN A 1 193 ? -33.884 15.048  32.658  1.00 76.26  ? 193 GLN A CB  1 
ATOM   1407 C CG  . GLN A 1 193 ? -33.869 14.423  31.267  1.00 76.49  ? 193 GLN A CG  1 
ATOM   1408 C CD  . GLN A 1 193 ? -34.626 15.209  30.223  1.00 71.82  ? 193 GLN A CD  1 
ATOM   1409 O OE1 . GLN A 1 193 ? -34.199 16.280  29.800  1.00 74.22  ? 193 GLN A OE1 1 
ATOM   1410 N NE2 . GLN A 1 193 ? -35.737 14.663  29.755  1.00 68.73  ? 193 GLN A NE2 1 
ATOM   1411 N N   . THR A 1 194 ? -36.728 13.312  32.407  1.00 75.94  ? 194 THR A N   1 
ATOM   1412 C CA  . THR A 1 194 ? -37.326 12.010  32.129  1.00 71.50  ? 194 THR A CA  1 
ATOM   1413 C C   . THR A 1 194 ? -36.514 11.258  31.064  1.00 73.96  ? 194 THR A C   1 
ATOM   1414 O O   . THR A 1 194 ? -35.972 11.856  30.133  1.00 67.63  ? 194 THR A O   1 
ATOM   1415 C CB  . THR A 1 194 ? -38.794 12.159  31.699  1.00 64.84  ? 194 THR A CB  1 
ATOM   1416 O OG1 . THR A 1 194 ? -39.227 10.866  31.274  1.00 67.34  ? 194 THR A OG1 1 
ATOM   1417 C CG2 . THR A 1 194 ? -39.018 13.153  30.577  1.00 61.30  ? 194 THR A CG2 1 
ATOM   1418 N N   . TYR A 1 195 ? -36.454 9.926   31.197  1.00 71.25  ? 195 TYR A N   1 
ATOM   1419 C CA  . TYR A 1 195 ? -35.741 9.077   30.252  1.00 67.51  ? 195 TYR A CA  1 
ATOM   1420 C C   . TYR A 1 195 ? -36.583 7.849   29.903  1.00 67.28  ? 195 TYR A C   1 
ATOM   1421 O O   . TYR A 1 195 ? -36.934 7.052   30.774  1.00 63.12  ? 195 TYR A O   1 
ATOM   1422 C CB  . TYR A 1 195 ? -34.394 8.653   30.836  1.00 65.84  ? 195 TYR A CB  1 
ATOM   1423 C CG  . TYR A 1 195 ? -33.399 9.771   31.018  1.00 65.83  ? 195 TYR A CG  1 
ATOM   1424 C CD1 . TYR A 1 195 ? -32.783 10.371  29.930  1.00 67.88  ? 195 TYR A CD1 1 
ATOM   1425 C CD2 . TYR A 1 195 ? -33.057 10.222  32.283  1.00 66.05  ? 195 TYR A CD2 1 
ATOM   1426 C CE1 . TYR A 1 195 ? -31.848 11.383  30.091  1.00 65.19  ? 195 TYR A CE1 1 
ATOM   1427 C CE2 . TYR A 1 195 ? -32.123 11.233  32.461  1.00 69.75  ? 195 TYR A CE2 1 
ATOM   1428 C CZ  . TYR A 1 195 ? -31.520 11.820  31.362  1.00 64.82  ? 195 TYR A CZ  1 
ATOM   1429 O OH  . TYR A 1 195 ? -30.602 12.828  31.542  1.00 66.17  ? 195 TYR A OH  1 
ATOM   1430 N N   . ILE A 1 196 ? -36.885 7.709   28.607  1.00 65.06  ? 196 ILE A N   1 
ATOM   1431 C CA  . ILE A 1 196 ? -37.679 6.609   28.083  1.00 67.56  ? 196 ILE A CA  1 
ATOM   1432 C C   . ILE A 1 196 ? -36.878 5.877   27.000  1.00 70.65  ? 196 ILE A C   1 
ATOM   1433 O O   . ILE A 1 196 ? -36.387 6.504   26.057  1.00 63.17  ? 196 ILE A O   1 
ATOM   1434 C CB  . ILE A 1 196 ? -39.008 7.151   27.524  1.00 64.57  ? 196 ILE A CB  1 
ATOM   1435 C CG1 . ILE A 1 196 ? -39.724 8.053   28.537  1.00 71.70  ? 196 ILE A CG1 1 
ATOM   1436 C CG2 . ILE A 1 196 ? -39.891 6.005   27.052  1.00 62.95  ? 196 ILE A CG2 1 
ATOM   1437 C CD1 . ILE A 1 196 ? -40.796 8.938   27.933  1.00 68.38  ? 196 ILE A CD1 1 
ATOM   1438 N N   . CYS A 1 197 ? -36.759 4.544   27.121  1.00 67.42  ? 197 CYS A N   1 
ATOM   1439 C CA  . CYS A 1 197 ? -36.218 3.738   26.034  1.00 66.62  ? 197 CYS A CA  1 
ATOM   1440 C C   . CYS A 1 197 ? -37.371 3.210   25.170  1.00 56.48  ? 197 CYS A C   1 
ATOM   1441 O O   . CYS A 1 197 ? -38.295 2.574   25.678  1.00 42.21  ? 197 CYS A O   1 
ATOM   1442 C CB  . CYS A 1 197 ? -35.308 2.620   26.536  1.00 69.68  ? 197 CYS A CB  1 
ATOM   1443 S SG  . CYS A 1 197 ? -36.154 1.056   26.895  1.00 77.58  ? 197 CYS A SG  1 
ATOM   1444 N N   . ASN A 1 198 ? -37.281 3.503   23.857  1.00 57.10  ? 198 ASN A N   1 
ATOM   1445 C CA  . ASN A 1 198 ? -38.247 3.105   22.837  1.00 57.73  ? 198 ASN A CA  1 
ATOM   1446 C C   . ASN A 1 198 ? -37.749 1.827   22.154  1.00 57.72  ? 198 ASN A C   1 
ATOM   1447 O O   . ASN A 1 198 ? -36.706 1.851   21.489  1.00 52.92  ? 198 ASN A O   1 
ATOM   1448 C CB  . ASN A 1 198 ? -38.451 4.217   21.794  1.00 56.65  ? 198 ASN A CB  1 
ATOM   1449 C CG  . ASN A 1 198 ? -38.424 5.623   22.373  1.00 59.85  ? 198 ASN A CG  1 
ATOM   1450 O OD1 . ASN A 1 198 ? -37.441 6.356   22.248  1.00 55.98  ? 198 ASN A OD1 1 
ATOM   1451 N ND2 . ASN A 1 198 ? -39.502 6.005   23.032  1.00 60.73  ? 198 ASN A ND2 1 
ATOM   1452 N N   . VAL A 1 199 ? -38.505 0.728   22.326  1.00 54.80  ? 199 VAL A N   1 
ATOM   1453 C CA  . VAL A 1 199 ? -38.088 -0.604  21.912  1.00 56.99  ? 199 VAL A CA  1 
ATOM   1454 C C   . VAL A 1 199 ? -39.034 -1.090  20.831  1.00 55.24  ? 199 VAL A C   1 
ATOM   1455 O O   . VAL A 1 199 ? -40.239 -1.032  21.018  1.00 52.05  ? 199 VAL A O   1 
ATOM   1456 C CB  . VAL A 1 199 ? -38.089 -1.607  23.088  1.00 64.51  ? 199 VAL A CB  1 
ATOM   1457 C CG1 . VAL A 1 199 ? -38.104 -3.063  22.623  1.00 62.07  ? 199 VAL A CG1 1 
ATOM   1458 C CG2 . VAL A 1 199 ? -36.932 -1.367  24.051  1.00 66.34  ? 199 VAL A CG2 1 
ATOM   1459 N N   . ASN A 1 200 ? -38.481 -1.643  19.745  1.00 57.74  ? 200 ASN A N   1 
ATOM   1460 C CA  . ASN A 1 200 ? -39.309 -2.216  18.697  1.00 53.68  ? 200 ASN A CA  1 
ATOM   1461 C C   . ASN A 1 200 ? -38.736 -3.551  18.217  1.00 50.89  ? 200 ASN A C   1 
ATOM   1462 O O   . ASN A 1 200 ? -37.539 -3.679  17.957  1.00 53.53  ? 200 ASN A O   1 
ATOM   1463 C CB  . ASN A 1 200 ? -39.499 -1.225  17.548  1.00 51.62  ? 200 ASN A CB  1 
ATOM   1464 C CG  . ASN A 1 200 ? -40.609 -1.622  16.599  1.00 49.51  ? 200 ASN A CG  1 
ATOM   1465 O OD1 . ASN A 1 200 ? -41.207 -2.687  16.721  1.00 45.93  ? 200 ASN A OD1 1 
ATOM   1466 N ND2 . ASN A 1 200 ? -40.895 -0.758  15.646  1.00 52.72  ? 200 ASN A ND2 1 
ATOM   1467 N N   . HIS A 1 201 ? -39.634 -4.536  18.146  1.00 46.97  ? 201 HIS A N   1 
ATOM   1468 C CA  . HIS A 1 201 ? -39.408 -5.841  17.565  1.00 47.61  ? 201 HIS A CA  1 
ATOM   1469 C C   . HIS A 1 201 ? -40.501 -6.055  16.527  1.00 52.64  ? 201 HIS A C   1 
ATOM   1470 O O   . HIS A 1 201 ? -41.592 -6.460  16.890  1.00 53.22  ? 201 HIS A O   1 
ATOM   1471 C CB  . HIS A 1 201 ? -39.573 -6.909  18.650  1.00 50.27  ? 201 HIS A CB  1 
ATOM   1472 C CG  . HIS A 1 201 ? -39.364 -8.331  18.239  1.00 51.25  ? 201 HIS A CG  1 
ATOM   1473 N ND1 . HIS A 1 201 ? -40.378 -9.256  18.301  1.00 50.68  ? 201 HIS A ND1 1 
ATOM   1474 C CD2 . HIS A 1 201 ? -38.284 -9.012  17.827  1.00 52.42  ? 201 HIS A CD2 1 
ATOM   1475 C CE1 . HIS A 1 201 ? -39.922 -10.439 17.916  1.00 50.42  ? 201 HIS A CE1 1 
ATOM   1476 N NE2 . HIS A 1 201 ? -38.649 -10.313 17.635  1.00 48.32  ? 201 HIS A NE2 1 
ATOM   1477 N N   . LYS A 1 202 ? -40.208 -5.791  15.247  1.00 59.46  ? 202 LYS A N   1 
ATOM   1478 C CA  . LYS A 1 202 ? -41.203 -5.872  14.182  1.00 57.09  ? 202 LYS A CA  1 
ATOM   1479 C C   . LYS A 1 202 ? -41.708 -7.295  13.937  1.00 53.15  ? 202 LYS A C   1 
ATOM   1480 O O   . LYS A 1 202 ? -42.879 -7.462  13.608  1.00 53.31  ? 202 LYS A O   1 
ATOM   1481 C CB  . LYS A 1 202 ? -40.672 -5.328  12.852  1.00 58.21  ? 202 LYS A CB  1 
ATOM   1482 C CG  . LYS A 1 202 ? -40.713 -3.813  12.693  1.00 62.97  ? 202 LYS A CG  1 
ATOM   1483 C CD  . LYS A 1 202 ? -39.460 -3.102  13.168  1.00 67.79  ? 202 LYS A CD  1 
ATOM   1484 C CE  . LYS A 1 202 ? -39.508 -1.604  12.939  1.00 69.73  ? 202 LYS A CE  1 
ATOM   1485 N NZ  . LYS A 1 202 ? -39.386 -1.252  11.505  1.00 68.75  ? 202 LYS A NZ  1 
ATOM   1486 N N   . PRO A 1 203 ? -40.881 -8.365  14.003  1.00 51.02  ? 203 PRO A N   1 
ATOM   1487 C CA  . PRO A 1 203 ? -41.390 -9.718  13.751  1.00 48.36  ? 203 PRO A CA  1 
ATOM   1488 C C   . PRO A 1 203 ? -42.609 -10.150 14.578  1.00 55.23  ? 203 PRO A C   1 
ATOM   1489 O O   . PRO A 1 203 ? -43.347 -11.031 14.138  1.00 53.59  ? 203 PRO A O   1 
ATOM   1490 C CB  . PRO A 1 203 ? -40.192 -10.629 14.079  1.00 47.25  ? 203 PRO A CB  1 
ATOM   1491 C CG  . PRO A 1 203 ? -38.973 -9.746  13.881  1.00 45.91  ? 203 PRO A CG  1 
ATOM   1492 C CD  . PRO A 1 203 ? -39.425 -8.339  14.233  1.00 48.42  ? 203 PRO A CD  1 
ATOM   1493 N N   . SER A 1 204 ? -42.812 -9.549  15.770  1.00 57.99  ? 204 SER A N   1 
ATOM   1494 C CA  . SER A 1 204 ? -43.945 -9.865  16.644  1.00 56.54  ? 204 SER A CA  1 
ATOM   1495 C C   . SER A 1 204 ? -44.806 -8.641  16.996  1.00 56.66  ? 204 SER A C   1 
ATOM   1496 O O   . SER A 1 204 ? -45.650 -8.720  17.891  1.00 55.05  ? 204 SER A O   1 
ATOM   1497 C CB  . SER A 1 204 ? -43.447 -10.480 17.919  1.00 51.74  ? 204 SER A CB  1 
ATOM   1498 O OG  . SER A 1 204 ? -42.890 -9.467  18.756  1.00 50.44  ? 204 SER A OG  1 
ATOM   1499 N N   . ASN A 1 205 ? -44.534 -7.491  16.365  1.00 57.07  ? 205 ASN A N   1 
ATOM   1500 C CA  . ASN A 1 205 ? -45.273 -6.249  16.578  1.00 59.71  ? 205 ASN A CA  1 
ATOM   1501 C C   . ASN A 1 205 ? -45.051 -5.644  17.970  1.00 53.90  ? 205 ASN A C   1 
ATOM   1502 O O   . ASN A 1 205 ? -45.744 -4.708  18.343  1.00 57.68  ? 205 ASN A O   1 
ATOM   1503 C CB  . ASN A 1 205 ? -46.767 -6.439  16.289  1.00 54.44  ? 205 ASN A CB  1 
ATOM   1504 C CG  . ASN A 1 205 ? -46.995 -6.804  14.838  1.00 57.19  ? 205 ASN A CG  1 
ATOM   1505 O OD1 . ASN A 1 205 ? -46.527 -6.097  13.946  1.00 51.88  ? 205 ASN A OD1 1 
ATOM   1506 N ND2 . ASN A 1 205 ? -47.665 -7.919  14.586  1.00 57.88  ? 205 ASN A ND2 1 
ATOM   1507 N N   . THR A 1 206 ? -44.073 -6.128  18.733  1.00 48.59  ? 206 THR A N   1 
ATOM   1508 C CA  . THR A 1 206 ? -43.928 -5.695  20.110  1.00 51.45  ? 206 THR A CA  1 
ATOM   1509 C C   . THR A 1 206 ? -43.157 -4.378  20.159  1.00 57.59  ? 206 THR A C   1 
ATOM   1510 O O   . THR A 1 206 ? -41.961 -4.305  19.860  1.00 58.48  ? 206 THR A O   1 
ATOM   1511 C CB  . THR A 1 206 ? -43.333 -6.811  20.974  1.00 52.05  ? 206 THR A CB  1 
ATOM   1512 O OG1 . THR A 1 206 ? -44.178 -7.951  20.792  1.00 54.05  ? 206 THR A OG1 1 
ATOM   1513 C CG2 . THR A 1 206 ? -43.249 -6.444  22.441  1.00 54.41  ? 206 THR A CG2 1 
ATOM   1514 N N   . LYS A 1 207 ? -43.890 -3.347  20.586  1.00 55.95  ? 207 LYS A N   1 
ATOM   1515 C CA  . LYS A 1 207 ? -43.457 -1.962  20.590  1.00 55.48  ? 207 LYS A CA  1 
ATOM   1516 C C   . LYS A 1 207 ? -43.694 -1.453  22.016  1.00 51.52  ? 207 LYS A C   1 
ATOM   1517 O O   . LYS A 1 207 ? -44.753 -1.683  22.581  1.00 50.55  ? 207 LYS A O   1 
ATOM   1518 C CB  . LYS A 1 207 ? -44.282 -1.273  19.497  1.00 59.32  ? 207 LYS A CB  1 
ATOM   1519 C CG  . LYS A 1 207 ? -43.611 -0.245  18.595  1.00 63.31  ? 207 LYS A CG  1 
ATOM   1520 C CD  . LYS A 1 207 ? -44.589 0.234   17.521  1.00 66.09  ? 207 LYS A CD  1 
ATOM   1521 C CE  . LYS A 1 207 ? -43.965 0.811   16.267  1.00 73.82  ? 207 LYS A CE  1 
ATOM   1522 N NZ  . LYS A 1 207 ? -43.474 2.192   16.474  1.00 76.11  ? 207 LYS A NZ  1 
ATOM   1523 N N   . VAL A 1 208 ? -42.703 -0.819  22.641  1.00 49.29  ? 208 VAL A N   1 
ATOM   1524 C CA  . VAL A 1 208 ? -42.780 -0.562  24.067  1.00 52.39  ? 208 VAL A CA  1 
ATOM   1525 C C   . VAL A 1 208 ? -41.967 0.690   24.401  1.00 57.48  ? 208 VAL A C   1 
ATOM   1526 O O   . VAL A 1 208 ? -40.850 0.849   23.918  1.00 51.49  ? 208 VAL A O   1 
ATOM   1527 C CB  . VAL A 1 208 ? -42.288 -1.800  24.847  1.00 53.69  ? 208 VAL A CB  1 
ATOM   1528 C CG1 . VAL A 1 208 ? -42.106 -1.503  26.334  1.00 57.01  ? 208 VAL A CG1 1 
ATOM   1529 C CG2 . VAL A 1 208 ? -43.196 -3.010  24.640  1.00 48.73  ? 208 VAL A CG2 1 
ATOM   1530 N N   . ASP A 1 209 ? -42.521 1.558   25.261  1.00 65.80  ? 209 ASP A N   1 
ATOM   1531 C CA  . ASP A 1 209 ? -41.851 2.792   25.661  1.00 75.99  ? 209 ASP A CA  1 
ATOM   1532 C C   . ASP A 1 209 ? -41.708 2.846   27.182  1.00 75.14  ? 209 ASP A C   1 
ATOM   1533 O O   . ASP A 1 209 ? -42.395 3.620   27.847  1.00 80.76  ? 209 ASP A O   1 
ATOM   1534 C CB  . ASP A 1 209 ? -42.603 4.026   25.148  1.00 81.31  ? 209 ASP A CB  1 
ATOM   1535 C CG  . ASP A 1 209 ? -42.558 4.228   23.640  1.00 84.89  ? 209 ASP A CG  1 
ATOM   1536 O OD1 . ASP A 1 209 ? -41.748 3.552   22.972  1.00 87.13  ? 209 ASP A OD1 1 
ATOM   1537 O OD2 . ASP A 1 209 ? -43.340 5.066   23.144  1.00 84.37  ? 209 ASP A OD2 1 
ATOM   1538 N N   . LYS A 1 210 ? -40.791 2.036   27.724  1.00 72.86  ? 210 LYS A N   1 
ATOM   1539 C CA  . LYS A 1 210 ? -40.638 1.905   29.164  1.00 76.36  ? 210 LYS A CA  1 
ATOM   1540 C C   . LYS A 1 210 ? -39.925 3.134   29.720  1.00 77.62  ? 210 LYS A C   1 
ATOM   1541 O O   . LYS A 1 210 ? -38.981 3.640   29.114  1.00 68.88  ? 210 LYS A O   1 
ATOM   1542 C CB  . LYS A 1 210 ? -39.820 0.664   29.537  1.00 79.27  ? 210 LYS A CB  1 
ATOM   1543 C CG  . LYS A 1 210 ? -39.951 0.202   30.986  1.00 79.60  ? 210 LYS A CG  1 
ATOM   1544 C CD  . LYS A 1 210 ? -40.898 -0.973  31.169  1.00 79.73  ? 210 LYS A CD  1 
ATOM   1545 C CE  . LYS A 1 210 ? -42.302 -0.712  30.665  1.00 78.82  ? 210 LYS A CE  1 
ATOM   1546 N NZ  . LYS A 1 210 ? -43.084 -1.963  30.539  1.00 77.79  ? 210 LYS A NZ  1 
ATOM   1547 N N   . ARG A 1 211 ? -40.384 3.587   30.891  1.00 70.78  ? 211 ARG A N   1 
ATOM   1548 C CA  . ARG A 1 211 ? -39.772 4.708   31.574  1.00 69.68  ? 211 ARG A CA  1 
ATOM   1549 C C   . ARG A 1 211 ? -38.757 4.129   32.554  1.00 63.47  ? 211 ARG A C   1 
ATOM   1550 O O   . ARG A 1 211 ? -38.879 2.984   32.967  1.00 57.74  ? 211 ARG A O   1 
ATOM   1551 C CB  . ARG A 1 211 ? -40.865 5.560   32.230  1.00 74.72  ? 211 ARG A CB  1 
ATOM   1552 C CG  . ARG A 1 211 ? -40.387 6.918   32.724  1.00 78.75  ? 211 ARG A CG  1 
ATOM   1553 C CD  . ARG A 1 211 ? -41.496 7.700   33.401  1.00 85.95  ? 211 ARG A CD  1 
ATOM   1554 N NE  . ARG A 1 211 ? -40.956 8.697   34.321  1.00 83.95  ? 211 ARG A NE  1 
ATOM   1555 C CZ  . ARG A 1 211 ? -40.897 10.007  34.096  1.00 86.61  ? 211 ARG A CZ  1 
ATOM   1556 N NH1 . ARG A 1 211 ? -41.293 10.515  32.941  1.00 92.43  ? 211 ARG A NH1 1 
ATOM   1557 N NH2 . ARG A 1 211 ? -40.412 10.811  35.027  1.00 87.12  ? 211 ARG A NH2 1 
ATOM   1558 N N   . VAL A 1 212 ? -37.726 4.906   32.883  1.00 67.11  ? 212 VAL A N   1 
ATOM   1559 C CA  . VAL A 1 212 ? -36.633 4.399   33.697  1.00 80.62  ? 212 VAL A CA  1 
ATOM   1560 C C   . VAL A 1 212 ? -36.237 5.481   34.706  1.00 78.47  ? 212 VAL A C   1 
ATOM   1561 O O   . VAL A 1 212 ? -35.819 6.571   34.321  1.00 66.82  ? 212 VAL A O   1 
ATOM   1562 C CB  . VAL A 1 212 ? -35.446 3.950   32.811  1.00 86.69  ? 212 VAL A CB  1 
ATOM   1563 C CG1 . VAL A 1 212 ? -34.357 3.242   33.607  1.00 85.92  ? 212 VAL A CG1 1 
ATOM   1564 C CG2 . VAL A 1 212 ? -35.898 3.065   31.657  1.00 86.31  ? 212 VAL A CG2 1 
ATOM   1565 N N   . GLU A 1 213 ? -36.343 5.151   36.001  1.00 81.35  ? 213 GLU A N   1 
ATOM   1566 C CA  . GLU A 1 213 ? -36.270 6.145   37.059  1.00 89.16  ? 213 GLU A CA  1 
ATOM   1567 C C   . GLU A 1 213 ? -35.611 5.553   38.303  1.00 95.38  ? 213 GLU A C   1 
ATOM   1568 O O   . GLU A 1 213 ? -35.704 4.348   38.539  1.00 97.85  ? 213 GLU A O   1 
ATOM   1569 C CB  . GLU A 1 213 ? -37.677 6.661   37.363  1.00 91.41  ? 213 GLU A CB  1 
ATOM   1570 C CG  . GLU A 1 213 ? -38.695 5.556   37.592  1.00 95.20  ? 213 GLU A CG  1 
ATOM   1571 C CD  . GLU A 1 213 ? -40.111 5.963   37.228  1.00 96.77  ? 213 GLU A CD  1 
ATOM   1572 O OE1 . GLU A 1 213 ? -40.528 7.061   37.647  1.00 95.84  ? 213 GLU A OE1 1 
ATOM   1573 O OE2 . GLU A 1 213 ? -40.780 5.190   36.511  1.00 92.98  ? 213 GLU A OE2 1 
ATOM   1574 N N   . PRO A 1 214 ? -34.955 6.396   39.143  1.00 98.71  ? 214 PRO A N   1 
ATOM   1575 C CA  . PRO A 1 214 ? -34.238 5.937   40.339  1.00 96.07  ? 214 PRO A CA  1 
ATOM   1576 C C   . PRO A 1 214 ? -35.156 5.406   41.453  1.00 83.50  ? 214 PRO A C   1 
ATOM   1577 O O   . PRO A 1 214 ? -35.593 4.281   41.325  1.00 76.53  ? 214 PRO A O   1 
ATOM   1578 C CB  . PRO A 1 214 ? -33.512 7.188   40.874  1.00 94.12  ? 214 PRO A CB  1 
ATOM   1579 C CG  . PRO A 1 214 ? -33.636 8.231   39.774  1.00 92.35  ? 214 PRO A CG  1 
ATOM   1580 C CD  . PRO A 1 214 ? -34.873 7.858   38.986  1.00 94.34  ? 214 PRO A CD  1 
ATOM   1581 N N   . ASP B 2 1   ? -13.134 -19.002 -10.911 1.00 49.54  ? 1   ASP B N   1 
ATOM   1582 C CA  . ASP B 2 1   ? -11.768 -19.412 -10.492 1.00 45.13  ? 1   ASP B CA  1 
ATOM   1583 C C   . ASP B 2 1   ? -10.822 -18.203 -10.415 1.00 40.78  ? 1   ASP B C   1 
ATOM   1584 O O   . ASP B 2 1   ? -9.610  -18.384 -10.426 1.00 42.82  ? 1   ASP B O   1 
ATOM   1585 C CB  . ASP B 2 1   ? -11.249 -20.560 -11.375 1.00 46.58  ? 1   ASP B CB  1 
ATOM   1586 C CG  . ASP B 2 1   ? -11.305 -20.336 -12.878 1.00 47.89  ? 1   ASP B CG  1 
ATOM   1587 O OD1 . ASP B 2 1   ? -11.822 -19.291 -13.277 1.00 45.27  ? 1   ASP B OD1 1 
ATOM   1588 O OD2 . ASP B 2 1   ? -10.821 -21.225 -13.644 1.00 51.90  ? 1   ASP B OD2 1 
ATOM   1589 N N   . ILE B 2 2   ? -11.325 -16.967 -10.287 1.00 34.63  ? 2   ILE B N   1 
ATOM   1590 C CA  . ILE B 2 2   ? -10.453 -15.913 -9.786  1.00 33.13  ? 2   ILE B CA  1 
ATOM   1591 C C   . ILE B 2 2   ? -10.636 -15.833 -8.274  1.00 33.11  ? 2   ILE B C   1 
ATOM   1592 O O   . ILE B 2 2   ? -11.704 -15.471 -7.798  1.00 33.46  ? 2   ILE B O   1 
ATOM   1593 C CB  . ILE B 2 2   ? -10.629 -14.544 -10.472 1.00 30.37  ? 2   ILE B CB  1 
ATOM   1594 C CG1 . ILE B 2 2   ? -10.646 -14.660 -11.998 1.00 29.84  ? 2   ILE B CG1 1 
ATOM   1595 C CG2 . ILE B 2 2   ? -9.540  -13.607 -9.983  1.00 28.64  ? 2   ILE B CG2 1 
ATOM   1596 C CD1 . ILE B 2 2   ? -10.663 -13.343 -12.765 1.00 30.40  ? 2   ILE B CD1 1 
ATOM   1597 N N   . VAL B 2 3   ? -9.582  -16.212 -7.532  1.00 31.19  ? 3   VAL B N   1 
ATOM   1598 C CA  . VAL B 2 3   ? -9.578  -16.172 -6.077  1.00 27.89  ? 3   VAL B CA  1 
ATOM   1599 C C   . VAL B 2 3   ? -8.971  -14.839 -5.650  1.00 25.35  ? 3   VAL B C   1 
ATOM   1600 O O   . VAL B 2 3   ? -7.914  -14.436 -6.146  1.00 23.65  ? 3   VAL B O   1 
ATOM   1601 C CB  . VAL B 2 3   ? -8.800  -17.372 -5.481  1.00 34.46  ? 3   VAL B CB  1 
ATOM   1602 C CG1 . VAL B 2 3   ? -8.750  -17.349 -3.953  1.00 34.78  ? 3   VAL B CG1 1 
ATOM   1603 C CG2 . VAL B 2 3   ? -9.356  -18.714 -5.959  1.00 35.88  ? 3   VAL B CG2 1 
ATOM   1604 N N   . MET B 2 4   ? -9.682  -14.153 -4.743  1.00 24.71  ? 4   MET B N   1 
ATOM   1605 C CA  . MET B 2 4   ? -9.229  -12.912 -4.147  1.00 23.39  ? 4   MET B CA  1 
ATOM   1606 C C   . MET B 2 4   ? -8.807  -13.185 -2.704  1.00 22.54  ? 4   MET B C   1 
ATOM   1607 O O   . MET B 2 4   ? -9.532  -13.822 -1.953  1.00 22.94  ? 4   MET B O   1 
ATOM   1608 C CB  . MET B 2 4   ? -10.370 -11.893 -4.153  1.00 23.86  ? 4   MET B CB  1 
ATOM   1609 C CG  . MET B 2 4   ? -10.998 -11.732 -5.498  1.00 23.91  ? 4   MET B CG  1 
ATOM   1610 S SD  . MET B 2 4   ? -9.822  -11.134 -6.720  1.00 21.89  ? 4   MET B SD  1 
ATOM   1611 C CE  . MET B 2 4   ? -9.830  -9.398  -6.298  1.00 22.11  ? 4   MET B CE  1 
ATOM   1612 N N   . THR B 2 5   ? -7.623  -12.714 -2.324  1.00 21.76  ? 5   THR B N   1 
ATOM   1613 C CA  . THR B 2 5   ? -7.139  -12.896 -0.973  1.00 22.36  ? 5   THR B CA  1 
ATOM   1614 C C   . THR B 2 5   ? -6.703  -11.524 -0.488  1.00 20.56  ? 5   THR B C   1 
ATOM   1615 O O   . THR B 2 5   ? -5.881  -10.865 -1.112  1.00 20.58  ? 5   THR B O   1 
ATOM   1616 C CB  . THR B 2 5   ? -6.024  -13.952 -0.916  1.00 24.18  ? 5   THR B CB  1 
ATOM   1617 O OG1 . THR B 2 5   ? -4.963  -13.371 -1.657  1.00 34.69  ? 5   THR B OG1 1 
ATOM   1618 C CG2 . THR B 2 5   ? -6.360  -15.258 -1.587  1.00 22.97  ? 5   THR B CG2 1 
ATOM   1619 N N   . GLN B 2 6   ? -7.335  -11.092 0.600   1.00 23.37  ? 6   GLN B N   1 
ATOM   1620 C CA  . GLN B 2 6   ? -7.056  -9.823  1.222   1.00 25.32  ? 6   GLN B CA  1 
ATOM   1621 C C   . GLN B 2 6   ? -6.137  -10.091 2.399   1.00 24.72  ? 6   GLN B C   1 
ATOM   1622 O O   . GLN B 2 6   ? -6.212  -11.166 2.971   1.00 27.08  ? 6   GLN B O   1 
ATOM   1623 C CB  . GLN B 2 6   ? -8.349  -9.224  1.773   1.00 26.45  ? 6   GLN B CB  1 
ATOM   1624 C CG  . GLN B 2 6   ? -9.279  -8.681  0.719   1.00 25.35  ? 6   GLN B CG  1 
ATOM   1625 C CD  . GLN B 2 6   ? -10.502 -8.029  1.317   1.00 22.02  ? 6   GLN B CD  1 
ATOM   1626 O OE1 . GLN B 2 6   ? -11.609 -8.253  0.863   1.00 22.31  ? 6   GLN B OE1 1 
ATOM   1627 N NE2 . GLN B 2 6   ? -10.321 -7.201  2.326   1.00 22.47  ? 6   GLN B NE2 1 
ATOM   1628 N N   . SER B 2 7   ? -5.339  -9.092  2.771   1.00 25.15  ? 7   SER B N   1 
ATOM   1629 C CA  . SER B 2 7   ? -4.465  -9.148  3.930   1.00 28.51  ? 7   SER B CA  1 
ATOM   1630 C C   . SER B 2 7   ? -4.157  -7.732  4.401   1.00 25.93  ? 7   SER B C   1 
ATOM   1631 O O   . SER B 2 7   ? -4.061  -6.809  3.581   1.00 22.80  ? 7   SER B O   1 
ATOM   1632 C CB  . SER B 2 7   ? -3.181  -9.892  3.651   1.00 30.01  ? 7   SER B CB  1 
ATOM   1633 O OG  . SER B 2 7   ? -2.578  -9.385  2.474   1.00 36.11  ? 7   SER B OG  1 
ATOM   1634 N N   . PRO B 2 8   ? -4.058  -7.523  5.736   1.00 23.66  ? 8   PRO B N   1 
ATOM   1635 C CA  . PRO B 2 8   ? -4.382  -8.569  6.713   1.00 25.83  ? 8   PRO B CA  1 
ATOM   1636 C C   . PRO B 2 8   ? -5.898  -8.745  6.882   1.00 27.19  ? 8   PRO B C   1 
ATOM   1637 O O   . PRO B 2 8   ? -6.680  -8.036  6.262   1.00 27.52  ? 8   PRO B O   1 
ATOM   1638 C CB  . PRO B 2 8   ? -3.723  -8.044  8.008   1.00 25.51  ? 8   PRO B CB  1 
ATOM   1639 C CG  . PRO B 2 8   ? -3.807  -6.529  7.864   1.00 25.68  ? 8   PRO B CG  1 
ATOM   1640 C CD  . PRO B 2 8   ? -3.659  -6.263  6.371   1.00 23.27  ? 8   PRO B CD  1 
ATOM   1641 N N   . ASP B 2 9   ? -6.286  -9.714  7.714   1.00 29.58  ? 9   ASP B N   1 
ATOM   1642 C CA  . ASP B 2 9   ? -7.669  -10.079 7.952   1.00 31.02  ? 9   ASP B CA  1 
ATOM   1643 C C   . ASP B 2 9   ? -8.322  -9.036  8.852   1.00 30.55  ? 9   ASP B C   1 
ATOM   1644 O O   . ASP B 2 9   ? -9.535  -8.831  8.795   1.00 27.83  ? 9   ASP B O   1 
ATOM   1645 C CB  . ASP B 2 9   ? -7.737  -11.464 8.587   1.00 33.74  ? 9   ASP B CB  1 
ATOM   1646 C CG  . ASP B 2 9   ? -7.583  -12.610 7.596   1.00 39.78  ? 9   ASP B CG  1 
ATOM   1647 O OD1 . ASP B 2 9   ? -7.657  -12.363 6.372   1.00 40.38  ? 9   ASP B OD1 1 
ATOM   1648 O OD2 . ASP B 2 9   ? -7.404  -13.754 8.058   1.00 44.77  ? 9   ASP B OD2 1 
ATOM   1649 N N   . SER B 2 10  ? -7.506  -8.460  9.737   1.00 28.56  ? 10  SER B N   1 
ATOM   1650 C CA  . SER B 2 10  ? -7.893  -7.336  10.564  1.00 33.06  ? 10  SER B CA  1 
ATOM   1651 C C   . SER B 2 10  ? -6.645  -6.542  10.906  1.00 32.01  ? 10  SER B C   1 
ATOM   1652 O O   . SER B 2 10  ? -5.522  -7.015  10.766  1.00 39.76  ? 10  SER B O   1 
ATOM   1653 C CB  . SER B 2 10  ? -8.690  -7.733  11.806  1.00 36.30  ? 10  SER B CB  1 
ATOM   1654 O OG  . SER B 2 10  ? -7.995  -8.648  12.635  1.00 37.20  ? 10  SER B OG  1 
ATOM   1655 N N   . LEU B 2 11  ? -6.873  -5.317  11.339  1.00 32.46  ? 11  LEU B N   1 
ATOM   1656 C CA  . LEU B 2 11  ? -5.869  -4.275  11.321  1.00 34.68  ? 11  LEU B CA  1 
ATOM   1657 C C   . LEU B 2 11  ? -6.362  -3.195  12.279  1.00 38.44  ? 11  LEU B C   1 
ATOM   1658 O O   . LEU B 2 11  ? -7.523  -2.795  12.190  1.00 34.50  ? 11  LEU B O   1 
ATOM   1659 C CB  . LEU B 2 11  ? -5.820  -3.782  9.871   1.00 37.43  ? 11  LEU B CB  1 
ATOM   1660 C CG  . LEU B 2 11  ? -4.960  -2.567  9.577   1.00 40.15  ? 11  LEU B CG  1 
ATOM   1661 C CD1 . LEU B 2 11  ? -3.502  -2.963  9.400   1.00 44.73  ? 11  LEU B CD1 1 
ATOM   1662 C CD2 . LEU B 2 11  ? -5.452  -1.869  8.330   1.00 42.53  ? 11  LEU B CD2 1 
ATOM   1663 N N   . ALA B 2 12  ? -5.498  -2.740  13.196  1.00 41.66  ? 12  ALA B N   1 
ATOM   1664 C CA  . ALA B 2 12  ? -5.799  -1.597  14.046  1.00 40.45  ? 12  ALA B CA  1 
ATOM   1665 C C   . ALA B 2 12  ? -4.778  -0.501  13.775  1.00 34.01  ? 12  ALA B C   1 
ATOM   1666 O O   . ALA B 2 12  ? -3.594  -0.764  13.837  1.00 34.47  ? 12  ALA B O   1 
ATOM   1667 C CB  . ALA B 2 12  ? -5.797  -2.002  15.507  1.00 44.38  ? 12  ALA B CB  1 
ATOM   1668 N N   . VAL B 2 13  ? -5.255  0.717   13.487  1.00 31.24  ? 13  VAL B N   1 
ATOM   1669 C CA  . VAL B 2 13  ? -4.412  1.813   13.056  1.00 31.55  ? 13  VAL B CA  1 
ATOM   1670 C C   . VAL B 2 13  ? -4.800  3.032   13.879  1.00 35.59  ? 13  VAL B C   1 
ATOM   1671 O O   . VAL B 2 13  ? -5.941  3.155   14.307  1.00 32.42  ? 13  VAL B O   1 
ATOM   1672 C CB  . VAL B 2 13  ? -4.581  2.081   11.546  1.00 34.84  ? 13  VAL B CB  1 
ATOM   1673 C CG1 . VAL B 2 13  ? -3.852  3.336   11.086  1.00 34.00  ? 13  VAL B CG1 1 
ATOM   1674 C CG2 . VAL B 2 13  ? -4.139  0.886   10.713  1.00 34.44  ? 13  VAL B CG2 1 
ATOM   1675 N N   . SER B 2 14  ? -3.840  3.931   14.085  1.00 38.50  ? 14  SER B N   1 
ATOM   1676 C CA  . SER B 2 14  ? -4.051  5.078   14.944  1.00 38.61  ? 14  SER B CA  1 
ATOM   1677 C C   . SER B 2 14  ? -4.728  6.195   14.151  1.00 38.87  ? 14  SER B C   1 
ATOM   1678 O O   . SER B 2 14  ? -4.377  6.470   12.994  1.00 37.35  ? 14  SER B O   1 
ATOM   1679 C CB  . SER B 2 14  ? -2.746  5.519   15.585  1.00 38.15  ? 14  SER B CB  1 
ATOM   1680 O OG  . SER B 2 14  ? -2.331  4.591   16.585  1.00 37.83  ? 14  SER B OG  1 
ATOM   1681 N N   . LEU B 2 15  ? -5.699  6.841   14.805  1.00 33.41  ? 15  LEU B N   1 
ATOM   1682 C CA  . LEU B 2 15  ? -6.347  8.021   14.256  1.00 33.93  ? 15  LEU B CA  1 
ATOM   1683 C C   . LEU B 2 15  ? -5.275  8.923   13.644  1.00 29.87  ? 15  LEU B C   1 
ATOM   1684 O O   . LEU B 2 15  ? -4.237  9.145   14.227  1.00 29.83  ? 15  LEU B O   1 
ATOM   1685 C CB  . LEU B 2 15  ? -7.134  8.701   15.382  1.00 39.22  ? 15  LEU B CB  1 
ATOM   1686 C CG  . LEU B 2 15  ? -8.584  9.069   15.063  1.00 47.23  ? 15  LEU B CG  1 
ATOM   1687 C CD1 . LEU B 2 15  ? -9.440  7.820   14.880  1.00 46.13  ? 15  LEU B CD1 1 
ATOM   1688 C CD2 . LEU B 2 15  ? -9.184  9.967   16.147  1.00 49.00  ? 15  LEU B CD2 1 
ATOM   1689 N N   . GLY B 2 16  ? -5.448  9.346   12.395  1.00 31.66  ? 16  GLY B N   1 
ATOM   1690 C CA  . GLY B 2 16  ? -4.474  10.223  11.761  1.00 30.14  ? 16  GLY B CA  1 
ATOM   1691 C C   . GLY B 2 16  ? -3.373  9.509   10.974  1.00 29.27  ? 16  GLY B C   1 
ATOM   1692 O O   . GLY B 2 16  ? -2.626  10.177  10.259  1.00 31.99  ? 16  GLY B O   1 
ATOM   1693 N N   . GLU B 2 17  ? -3.260  8.175   11.087  1.00 32.34  ? 17  GLU B N   1 
ATOM   1694 C CA  . GLU B 2 17  ? -2.162  7.458   10.438  1.00 38.48  ? 17  GLU B CA  1 
ATOM   1695 C C   . GLU B 2 17  ? -2.621  6.892   9.089   1.00 39.13  ? 17  GLU B C   1 
ATOM   1696 O O   . GLU B 2 17  ? -3.787  7.017   8.715   1.00 38.54  ? 17  GLU B O   1 
ATOM   1697 C CB  . GLU B 2 17  ? -1.659  6.283   11.284  1.00 41.65  ? 17  GLU B CB  1 
ATOM   1698 C CG  . GLU B 2 17  ? -1.228  6.619   12.696  1.00 45.88  ? 17  GLU B CG  1 
ATOM   1699 C CD  . GLU B 2 17  ? 0.070   7.383   12.851  1.00 48.23  ? 17  GLU B CD  1 
ATOM   1700 O OE1 . GLU B 2 17  ? 0.698   7.235   13.918  1.00 60.33  ? 17  GLU B OE1 1 
ATOM   1701 O OE2 . GLU B 2 17  ? 0.417   8.154   11.946  1.00 48.88  ? 17  GLU B OE2 1 
ATOM   1702 N N   . ARG B 2 18  ? -1.704  6.209   8.389   1.00 39.21  ? 18  ARG B N   1 
ATOM   1703 C CA  . ARG B 2 18  ? -2.031  5.540   7.141   1.00 36.93  ? 18  ARG B CA  1 
ATOM   1704 C C   . ARG B 2 18  ? -2.519  4.110   7.380   1.00 32.75  ? 18  ARG B C   1 
ATOM   1705 O O   . ARG B 2 18  ? -1.784  3.301   7.917   1.00 31.27  ? 18  ARG B O   1 
ATOM   1706 C CB  . ARG B 2 18  ? -0.820  5.541   6.219   1.00 38.91  ? 18  ARG B CB  1 
ATOM   1707 C CG  . ARG B 2 18  ? -1.162  5.104   4.804   1.00 42.82  ? 18  ARG B CG  1 
ATOM   1708 C CD  . ARG B 2 18  ? -0.265  5.768   3.781   1.00 44.71  ? 18  ARG B CD  1 
ATOM   1709 N NE  . ARG B 2 18  ? 0.869   4.921   3.482   1.00 49.72  ? 18  ARG B NE  1 
ATOM   1710 C CZ  . ARG B 2 18  ? 2.109   5.331   3.250   1.00 51.00  ? 18  ARG B CZ  1 
ATOM   1711 N NH1 . ARG B 2 18  ? 2.410   6.617   3.287   1.00 51.63  ? 18  ARG B NH1 1 
ATOM   1712 N NH2 . ARG B 2 18  ? 3.039   4.432   2.971   1.00 53.46  ? 18  ARG B NH2 1 
ATOM   1713 N N   . ALA B 2 19  ? -3.754  3.813   6.942   1.00 31.04  ? 19  ALA B N   1 
ATOM   1714 C CA  . ALA B 2 19  ? -4.284  2.454   6.844   1.00 31.28  ? 19  ALA B CA  1 
ATOM   1715 C C   . ALA B 2 19  ? -4.110  1.901   5.427   1.00 30.29  ? 19  ALA B C   1 
ATOM   1716 O O   . ALA B 2 19  ? -4.516  2.534   4.458   1.00 30.45  ? 19  ALA B O   1 
ATOM   1717 C CB  . ALA B 2 19  ? -5.750  2.437   7.212   1.00 31.44  ? 19  ALA B CB  1 
ATOM   1718 N N   . THR B 2 20  ? -3.601  0.671   5.318   1.00 27.22  ? 20  THR B N   1 
ATOM   1719 C CA  . THR B 2 20  ? -3.338  0.049   4.029   1.00 29.26  ? 20  THR B CA  1 
ATOM   1720 C C   . THR B 2 20  ? -3.911  -1.357  4.067   1.00 28.41  ? 20  THR B C   1 
ATOM   1721 O O   . THR B 2 20  ? -3.608  -2.103  4.992   1.00 24.73  ? 20  THR B O   1 
ATOM   1722 C CB  . THR B 2 20  ? -1.833  0.080   3.710   1.00 28.31  ? 20  THR B CB  1 
ATOM   1723 O OG1 . THR B 2 20  ? -1.551  1.453   3.469   1.00 32.80  ? 20  THR B OG1 1 
ATOM   1724 C CG2 . THR B 2 20  ? -1.414  -0.690  2.487   1.00 28.77  ? 20  THR B CG2 1 
ATOM   1725 N N   . ILE B 2 21  ? -4.715  -1.703  3.045   1.00 29.60  ? 21  ILE B N   1 
ATOM   1726 C CA  . ILE B 2 21  ? -5.288  -3.037  2.913   1.00 25.94  ? 21  ILE B CA  1 
ATOM   1727 C C   . ILE B 2 21  ? -4.855  -3.615  1.569   1.00 24.55  ? 21  ILE B C   1 
ATOM   1728 O O   . ILE B 2 21  ? -4.881  -2.916  0.572   1.00 23.57  ? 21  ILE B O   1 
ATOM   1729 C CB  . ILE B 2 21  ? -6.821  -2.972  3.049   1.00 26.53  ? 21  ILE B CB  1 
ATOM   1730 C CG1 . ILE B 2 21  ? -7.228  -2.473  4.434   1.00 29.10  ? 21  ILE B CG1 1 
ATOM   1731 C CG2 . ILE B 2 21  ? -7.469  -4.313  2.721   1.00 27.13  ? 21  ILE B CG2 1 
ATOM   1732 C CD1 . ILE B 2 21  ? -8.632  -1.924  4.495   1.00 31.75  ? 21  ILE B CD1 1 
ATOM   1733 N N   . ASN B 2 22  ? -4.520  -4.914  1.529   1.00 24.74  ? 22  ASN B N   1 
ATOM   1734 C CA  . ASN B 2 22  ? -4.048  -5.510  0.296   1.00 24.07  ? 22  ASN B CA  1 
ATOM   1735 C C   . ASN B 2 22  ? -5.041  -6.547  -0.215  1.00 23.08  ? 22  ASN B C   1 
ATOM   1736 O O   . ASN B 2 22  ? -5.726  -7.222  0.541   1.00 25.43  ? 22  ASN B O   1 
ATOM   1737 C CB  . ASN B 2 22  ? -2.648  -6.097  0.433   1.00 25.61  ? 22  ASN B CB  1 
ATOM   1738 C CG  . ASN B 2 22  ? -1.687  -5.064  0.970   1.00 31.46  ? 22  ASN B CG  1 
ATOM   1739 O OD1 . ASN B 2 22  ? -1.348  -5.114  2.155   1.00 37.27  ? 22  ASN B OD1 1 
ATOM   1740 N ND2 . ASN B 2 22  ? -1.332  -4.072  0.152   1.00 30.86  ? 22  ASN B ND2 1 
ATOM   1741 N N   . CYS B 2 23  ? -5.092  -6.643  -1.538  1.00 21.96  ? 23  CYS B N   1 
ATOM   1742 C CA  . CYS B 2 23  ? -5.947  -7.583  -2.231  1.00 24.80  ? 23  CYS B CA  1 
ATOM   1743 C C   . CYS B 2 23  ? -5.082  -8.216  -3.307  1.00 21.57  ? 23  CYS B C   1 
ATOM   1744 O O   . CYS B 2 23  ? -4.364  -7.497  -3.993  1.00 21.08  ? 23  CYS B O   1 
ATOM   1745 C CB  . CYS B 2 23  ? -7.166  -6.866  -2.825  1.00 27.19  ? 23  CYS B CB  1 
ATOM   1746 S SG  . CYS B 2 23  ? -8.289  -7.929  -3.769  1.00 34.83  ? 23  CYS B SG  1 
ATOM   1747 N N   . LYS B 2 24  ? -5.141  -9.543  -3.428  1.00 20.60  ? 24  LYS B N   1 
ATOM   1748 C CA  . LYS B 2 24  ? -4.374  -10.221 -4.447  1.00 23.54  ? 24  LYS B CA  1 
ATOM   1749 C C   . LYS B 2 24  ? -5.304  -11.148 -5.212  1.00 23.98  ? 24  LYS B C   1 
ATOM   1750 O O   . LYS B 2 24  ? -6.046  -11.912 -4.584  1.00 27.11  ? 24  LYS B O   1 
ATOM   1751 C CB  . LYS B 2 24  ? -3.219  -10.942 -3.759  1.00 28.70  ? 24  LYS B CB  1 
ATOM   1752 C CG  . LYS B 2 24  ? -2.006  -11.219 -4.618  1.00 37.79  ? 24  LYS B CG  1 
ATOM   1753 C CD  . LYS B 2 24  ? -0.891  -11.886 -3.846  1.00 46.19  ? 24  LYS B CD  1 
ATOM   1754 C CE  . LYS B 2 24  ? 0.426   -11.833 -4.587  1.00 53.17  ? 24  LYS B CE  1 
ATOM   1755 N NZ  . LYS B 2 24  ? 0.243   -11.999 -6.049  1.00 52.99  ? 24  LYS B NZ  1 
ATOM   1756 N N   . SER B 2 25  ? -5.250  -11.096 -6.556  1.00 21.44  ? 25  SER B N   1 
ATOM   1757 C CA  . SER B 2 25  ? -6.060  -11.991 -7.366  1.00 22.33  ? 25  SER B CA  1 
ATOM   1758 C C   . SER B 2 25  ? -5.200  -13.132 -7.929  1.00 21.73  ? 25  SER B C   1 
ATOM   1759 O O   . SER B 2 25  ? -4.030  -12.939 -8.168  1.00 20.66  ? 25  SER B O   1 
ATOM   1760 C CB  . SER B 2 25  ? -6.814  -11.259 -8.441  1.00 22.21  ? 25  SER B CB  1 
ATOM   1761 O OG  . SER B 2 25  ? -5.960  -10.595 -9.346  1.00 22.75  ? 25  SER B OG  1 
ATOM   1762 N N   . SER B 2 26  ? -5.785  -14.326 -8.109  1.00 23.37  ? 26  SER B N   1 
ATOM   1763 C CA  . SER B 2 26  ? -5.038  -15.485 -8.589  1.00 24.04  ? 26  SER B CA  1 
ATOM   1764 C C   . SER B 2 26  ? -4.843  -15.412 -10.100 1.00 25.23  ? 26  SER B C   1 
ATOM   1765 O O   . SER B 2 26  ? -4.100  -16.208 -10.638 1.00 31.25  ? 26  SER B O   1 
ATOM   1766 C CB  . SER B 2 26  ? -5.702  -16.786 -8.209  1.00 22.75  ? 26  SER B CB  1 
ATOM   1767 O OG  . SER B 2 26  ? -7.058  -16.792 -8.635  1.00 24.81  ? 26  SER B OG  1 
ATOM   1768 N N   . GLN B 2 27  ? -5.544  -14.497 -10.787 1.00 24.88  ? 27  GLN B N   1 
ATOM   1769 C CA  . GLN B 2 27  ? -5.302  -14.192 -12.189 1.00 22.11  ? 27  GLN B CA  1 
ATOM   1770 C C   . GLN B 2 27  ? -5.450  -12.682 -12.361 1.00 21.46  ? 27  GLN B C   1 
ATOM   1771 O O   . GLN B 2 27  ? -6.050  -12.001 -11.519 1.00 20.95  ? 27  GLN B O   1 
ATOM   1772 C CB  . GLN B 2 27  ? -6.292  -14.888 -13.136 1.00 26.97  ? 27  GLN B CB  1 
ATOM   1773 C CG  . GLN B 2 27  ? -6.578  -16.363 -12.845 1.00 33.53  ? 27  GLN B CG  1 
ATOM   1774 C CD  . GLN B 2 27  ? -7.600  -16.949 -13.795 1.00 38.58  ? 27  GLN B CD  1 
ATOM   1775 O OE1 . GLN B 2 27  ? -7.826  -16.442 -14.893 1.00 49.26  ? 27  GLN B OE1 1 
ATOM   1776 N NE2 . GLN B 2 27  ? -8.247  -18.026 -13.383 1.00 37.87  ? 27  GLN B NE2 1 
ATOM   1777 N N   . SER B 2 28  ? -4.874  -12.162 -13.449 1.00 18.96  ? 28  SER B N   1 
ATOM   1778 C CA  . SER B 2 28  ? -4.932  -10.749 -13.734 1.00 19.22  ? 28  SER B CA  1 
ATOM   1779 C C   . SER B 2 28  ? -6.381  -10.351 -13.986 1.00 19.77  ? 28  SER B C   1 
ATOM   1780 O O   . SER B 2 28  ? -7.124  -11.085 -14.630 1.00 22.18  ? 28  SER B O   1 
ATOM   1781 C CB  . SER B 2 28  ? -4.090  -10.365 -14.911 1.00 17.77  ? 28  SER B CB  1 
ATOM   1782 O OG  . SER B 2 28  ? -4.240  -8.972  -15.141 1.00 17.51  ? 28  SER B OG  1 
ATOM   1783 N N   . VAL B 2 29  ? -6.737  -9.160  -13.505 1.00 19.83  ? 29  VAL B N   1 
ATOM   1784 C CA  . VAL B 2 29  ? -8.032  -8.556  -13.769 1.00 19.05  ? 29  VAL B CA  1 
ATOM   1785 C C   . VAL B 2 29  ? -7.872  -7.337  -14.667 1.00 17.72  ? 29  VAL B C   1 
ATOM   1786 O O   . VAL B 2 29  ? -8.807  -6.543  -14.787 1.00 17.58  ? 29  VAL B O   1 
ATOM   1787 C CB  . VAL B 2 29  ? -8.750  -8.222  -12.448 1.00 18.66  ? 29  VAL B CB  1 
ATOM   1788 C CG1 . VAL B 2 29  ? -8.963  -9.473  -11.630 1.00 18.36  ? 29  VAL B CG1 1 
ATOM   1789 C CG2 . VAL B 2 29  ? -8.022  -7.171  -11.630 1.00 20.63  ? 29  VAL B CG2 1 
ATOM   1790 N N   . LEU B 2 30  ? -6.689  -7.200  -15.276 1.00 19.02  ? 30  LEU B N   1 
ATOM   1791 C CA  . LEU B 2 30  ? -6.408  -6.192  -16.295 1.00 21.23  ? 30  LEU B CA  1 
ATOM   1792 C C   . LEU B 2 30  ? -6.874  -6.726  -17.642 1.00 21.63  ? 30  LEU B C   1 
ATOM   1793 O O   . LEU B 2 30  ? -6.357  -7.748  -18.110 1.00 24.08  ? 30  LEU B O   1 
ATOM   1794 C CB  . LEU B 2 30  ? -4.903  -5.881  -16.370 1.00 21.79  ? 30  LEU B CB  1 
ATOM   1795 C CG  . LEU B 2 30  ? -4.461  -4.836  -17.404 1.00 21.25  ? 30  LEU B CG  1 
ATOM   1796 C CD1 . LEU B 2 30  ? -5.101  -3.484  -17.141 1.00 20.36  ? 30  LEU B CD1 1 
ATOM   1797 C CD2 . LEU B 2 30  ? -2.938  -4.651  -17.415 1.00 21.76  ? 30  LEU B CD2 1 
ATOM   1798 N N   . TYR B 2 31  ? -7.831  -6.018  -18.252 1.00 20.03  ? 31  TYR B N   1 
ATOM   1799 C CA  . TYR B 2 31  ? -8.320  -6.375  -19.571 1.00 20.67  ? 31  TYR B CA  1 
ATOM   1800 C C   . TYR B 2 31  ? -7.447  -5.715  -20.638 1.00 21.93  ? 31  TYR B C   1 
ATOM   1801 O O   . TYR B 2 31  ? -7.274  -4.488  -20.673 1.00 22.31  ? 31  TYR B O   1 
ATOM   1802 C CB  . TYR B 2 31  ? -9.777  -5.974  -19.753 1.00 20.82  ? 31  TYR B CB  1 
ATOM   1803 C CG  . TYR B 2 31  ? -10.484 -6.758  -20.829 1.00 21.10  ? 31  TYR B CG  1 
ATOM   1804 C CD1 . TYR B 2 31  ? -10.547 -8.148  -20.772 1.00 22.01  ? 31  TYR B CD1 1 
ATOM   1805 C CD2 . TYR B 2 31  ? -11.108 -6.121  -21.889 1.00 19.80  ? 31  TYR B CD2 1 
ATOM   1806 C CE1 . TYR B 2 31  ? -11.218 -8.881  -21.737 1.00 22.58  ? 31  TYR B CE1 1 
ATOM   1807 C CE2 . TYR B 2 31  ? -11.783 -6.837  -22.871 1.00 18.83  ? 31  TYR B CE2 1 
ATOM   1808 C CZ  . TYR B 2 31  ? -11.864 -8.213  -22.775 1.00 22.16  ? 31  TYR B CZ  1 
ATOM   1809 O OH  . TYR B 2 31  ? -12.543 -8.900  -23.748 1.00 19.03  ? 31  TYR B OH  1 
ATOM   1810 N N   . SER B 2 32  ? -6.866  -6.573  -21.469 1.00 19.81  ? 32  SER B N   1 
ATOM   1811 C CA  . SER B 2 32  ? -5.814  -6.215  -22.394 1.00 21.31  ? 32  SER B CA  1 
ATOM   1812 C C   . SER B 2 32  ? -6.227  -5.050  -23.291 1.00 18.98  ? 32  SER B C   1 
ATOM   1813 O O   . SER B 2 32  ? -5.510  -4.076  -23.448 1.00 17.88  ? 32  SER B O   1 
ATOM   1814 C CB  . SER B 2 32  ? -5.491  -7.405  -23.222 1.00 22.14  ? 32  SER B CB  1 
ATOM   1815 O OG  . SER B 2 32  ? -4.476  -7.045  -24.132 1.00 32.66  ? 32  SER B OG  1 
ATOM   1816 N N   . SER B 2 33  ? -7.407  -5.197  -23.864 1.00 18.19  ? 33  SER B N   1 
ATOM   1817 C CA  . SER B 2 33  ? -8.000  -4.321  -24.853 1.00 20.47  ? 33  SER B CA  1 
ATOM   1818 C C   . SER B 2 33  ? -8.138  -2.886  -24.372 1.00 18.36  ? 33  SER B C   1 
ATOM   1819 O O   . SER B 2 33  ? -7.982  -1.981  -25.160 1.00 18.83  ? 33  SER B O   1 
ATOM   1820 C CB  . SER B 2 33  ? -9.391  -4.861  -25.174 1.00 21.91  ? 33  SER B CB  1 
ATOM   1821 O OG  . SER B 2 33  ? -9.257  -6.034  -25.939 1.00 27.28  ? 33  SER B OG  1 
ATOM   1822 N N   . ASN B 2 34  ? -8.596  -2.692  -23.134 1.00 17.61  ? 34  ASN B N   1 
ATOM   1823 C CA  . ASN B 2 34  ? -8.944  -1.350  -22.691 1.00 19.37  ? 34  ASN B CA  1 
ATOM   1824 C C   . ASN B 2 34  ? -8.041  -0.886  -21.549 1.00 18.05  ? 34  ASN B C   1 
ATOM   1825 O O   . ASN B 2 34  ? -8.179  0.241   -21.105 1.00 19.96  ? 34  ASN B O   1 
ATOM   1826 C CB  . ASN B 2 34  ? -10.427 -1.254  -22.349 1.00 18.59  ? 34  ASN B CB  1 
ATOM   1827 C CG  . ASN B 2 34  ? -10.817 -2.237  -21.279 1.00 19.75  ? 34  ASN B CG  1 
ATOM   1828 O OD1 . ASN B 2 34  ? -10.044 -2.472  -20.355 1.00 20.82  ? 34  ASN B OD1 1 
ATOM   1829 N ND2 . ASN B 2 34  ? -11.985 -2.844  -21.414 1.00 20.25  ? 34  ASN B ND2 1 
ATOM   1830 N N   . GLN B 2 35  ? -7.092  -1.729  -21.117 1.00 16.75  ? 35  GLN B N   1 
ATOM   1831 C CA  . GLN B 2 35  ? -6.129  -1.366  -20.088 1.00 17.74  ? 35  GLN B CA  1 
ATOM   1832 C C   . GLN B 2 35  ? -6.851  -0.938  -18.819 1.00 17.77  ? 35  GLN B C   1 
ATOM   1833 O O   . GLN B 2 35  ? -6.301  -0.144  -18.067 1.00 18.51  ? 35  GLN B O   1 
ATOM   1834 C CB  . GLN B 2 35  ? -5.168  -0.266  -20.577 1.00 17.42  ? 35  GLN B CB  1 
ATOM   1835 C CG  . GLN B 2 35  ? -4.283  -0.758  -21.708 1.00 18.35  ? 35  GLN B CG  1 
ATOM   1836 C CD  . GLN B 2 35  ? -3.461  -1.927  -21.201 1.00 18.84  ? 35  GLN B CD  1 
ATOM   1837 O OE1 . GLN B 2 35  ? -2.774  -1.830  -20.199 1.00 21.21  ? 35  GLN B OE1 1 
ATOM   1838 N NE2 . GLN B 2 35  ? -3.565  -3.080  -21.834 1.00 18.88  ? 35  GLN B NE2 1 
ATOM   1839 N N   . MET B 2 36  ? -8.040  -1.497  -18.548 1.00 16.95  ? 36  MET B N   1 
ATOM   1840 C CA  . MET B 2 36  ? -8.671  -1.215  -17.275 1.00 18.13  ? 36  MET B CA  1 
ATOM   1841 C C   . MET B 2 36  ? -8.507  -2.421  -16.359 1.00 17.88  ? 36  MET B C   1 
ATOM   1842 O O   . MET B 2 36  ? -8.521  -3.561  -16.817 1.00 19.69  ? 36  MET B O   1 
ATOM   1843 C CB  . MET B 2 36  ? -10.149 -0.855  -17.484 1.00 19.67  ? 36  MET B CB  1 
ATOM   1844 C CG  . MET B 2 36  ? -10.287 0.540   -18.059 1.00 20.57  ? 36  MET B CG  1 
ATOM   1845 S SD  . MET B 2 36  ? -11.968 1.216   -18.218 1.00 24.12  ? 36  MET B SD  1 
ATOM   1846 C CE  . MET B 2 36  ? -12.852 -0.161  -18.942 1.00 24.31  ? 36  MET B CE  1 
ATOM   1847 N N   . ASN B 2 37  ? -8.344  -2.162  -15.059 1.00 16.55  ? 37  ASN B N   1 
ATOM   1848 C CA  . ASN B 2 37  ? -8.409  -3.209  -14.050 1.00 16.21  ? 37  ASN B CA  1 
ATOM   1849 C C   . ASN B 2 37  ? -9.821  -3.307  -13.498 1.00 16.44  ? 37  ASN B C   1 
ATOM   1850 O O   . ASN B 2 37  ? -10.369 -2.318  -13.013 1.00 16.72  ? 37  ASN B O   1 
ATOM   1851 C CB  . ASN B 2 37  ? -7.475  -2.911  -12.887 1.00 17.22  ? 37  ASN B CB  1 
ATOM   1852 C CG  . ASN B 2 37  ? -6.037  -3.171  -13.255 1.00 16.21  ? 37  ASN B CG  1 
ATOM   1853 O OD1 . ASN B 2 37  ? -5.627  -4.323  -13.366 1.00 17.12  ? 37  ASN B OD1 1 
ATOM   1854 N ND2 . ASN B 2 37  ? -5.292  -2.115  -13.474 1.00 15.40  ? 37  ASN B ND2 1 
ATOM   1855 N N   . TYR B 2 38  ? -10.390 -4.511  -13.544 1.00 16.35  ? 38  TYR B N   1 
ATOM   1856 C CA  . TYR B 2 38  ? -11.784 -4.721  -13.201 1.00 16.10  ? 38  TYR B CA  1 
ATOM   1857 C C   . TYR B 2 38  ? -11.866 -5.033  -11.708 1.00 17.01  ? 38  TYR B C   1 
ATOM   1858 O O   . TYR B 2 38  ? -12.206 -6.152  -11.311 1.00 16.04  ? 38  TYR B O   1 
ATOM   1859 C CB  . TYR B 2 38  ? -12.368 -5.818  -14.100 1.00 16.64  ? 38  TYR B CB  1 
ATOM   1860 C CG  . TYR B 2 38  ? -12.753 -5.365  -15.487 1.00 17.06  ? 38  TYR B CG  1 
ATOM   1861 C CD1 . TYR B 2 38  ? -11.812 -4.882  -16.361 1.00 15.79  ? 38  TYR B CD1 1 
ATOM   1862 C CD2 . TYR B 2 38  ? -14.073 -5.421  -15.925 1.00 18.12  ? 38  TYR B CD2 1 
ATOM   1863 C CE1 . TYR B 2 38  ? -12.154 -4.424  -17.617 1.00 17.32  ? 38  TYR B CE1 1 
ATOM   1864 C CE2 . TYR B 2 38  ? -14.434 -5.010  -17.202 1.00 16.90  ? 38  TYR B CE2 1 
ATOM   1865 C CZ  . TYR B 2 38  ? -13.472 -4.491  -18.045 1.00 17.66  ? 38  TYR B CZ  1 
ATOM   1866 O OH  . TYR B 2 38  ? -13.801 -4.031  -19.306 1.00 17.50  ? 38  TYR B OH  1 
ATOM   1867 N N   . LEU B 2 39  ? -11.533 -4.033  -10.883 1.00 18.47  ? 39  LEU B N   1 
ATOM   1868 C CA  . LEU B 2 39  ? -11.415 -4.250  -9.452  1.00 17.86  ? 39  LEU B CA  1 
ATOM   1869 C C   . LEU B 2 39  ? -12.066 -3.091  -8.693  1.00 19.31  ? 39  LEU B C   1 
ATOM   1870 O O   . LEU B 2 39  ? -11.914 -1.933  -9.071  1.00 19.31  ? 39  LEU B O   1 
ATOM   1871 C CB  . LEU B 2 39  ? -9.945  -4.388  -9.061  1.00 19.78  ? 39  LEU B CB  1 
ATOM   1872 C CG  . LEU B 2 39  ? -9.775  -4.723  -7.578  1.00 20.88  ? 39  LEU B CG  1 
ATOM   1873 C CD1 . LEU B 2 39  ? -9.197  -6.104  -7.362  1.00 19.60  ? 39  LEU B CD1 1 
ATOM   1874 C CD2 . LEU B 2 39  ? -8.997  -3.665  -6.861  1.00 22.42  ? 39  LEU B CD2 1 
ATOM   1875 N N   . ALA B 2 40  ? -12.818 -3.424  -7.636  1.00 17.41  ? 40  ALA B N   1 
ATOM   1876 C CA  . ALA B 2 40  ? -13.535 -2.432  -6.850  1.00 18.51  ? 40  ALA B CA  1 
ATOM   1877 C C   . ALA B 2 40  ? -13.209 -2.627  -5.378  1.00 19.34  ? 40  ALA B C   1 
ATOM   1878 O O   . ALA B 2 40  ? -12.903 -3.726  -4.961  1.00 21.95  ? 40  ALA B O   1 
ATOM   1879 C CB  . ALA B 2 40  ? -15.033 -2.550  -7.050  1.00 17.82  ? 40  ALA B CB  1 
ATOM   1880 N N   . TRP B 2 41  ? -13.394 -1.575  -4.588  1.00 20.13  ? 41  TRP B N   1 
ATOM   1881 C CA  . TRP B 2 41  ? -13.273 -1.649  -3.149  1.00 20.19  ? 41  TRP B CA  1 
ATOM   1882 C C   . TRP B 2 41  ? -14.552 -1.157  -2.500  1.00 20.23  ? 41  TRP B C   1 
ATOM   1883 O O   . TRP B 2 41  ? -15.039 -0.094  -2.894  1.00 19.67  ? 41  TRP B O   1 
ATOM   1884 C CB  . TRP B 2 41  ? -12.105 -0.782  -2.693  1.00 21.28  ? 41  TRP B CB  1 
ATOM   1885 C CG  . TRP B 2 41  ? -10.754 -1.356  -2.969  1.00 21.84  ? 41  TRP B CG  1 
ATOM   1886 C CD1 . TRP B 2 41  ? -9.879  -0.992  -3.955  1.00 21.16  ? 41  TRP B CD1 1 
ATOM   1887 C CD2 . TRP B 2 41  ? -10.070 -2.327  -2.169  1.00 20.78  ? 41  TRP B CD2 1 
ATOM   1888 N NE1 . TRP B 2 41  ? -8.693  -1.661  -3.815  1.00 19.82  ? 41  TRP B NE1 1 
ATOM   1889 C CE2 . TRP B 2 41  ? -8.785  -2.500  -2.745  1.00 19.35  ? 41  TRP B CE2 1 
ATOM   1890 C CE3 . TRP B 2 41  ? -10.409 -3.052  -1.023  1.00 19.52  ? 41  TRP B CE3 1 
ATOM   1891 C CZ2 . TRP B 2 41  ? -7.857  -3.400  -2.232  1.00 18.60  ? 41  TRP B CZ2 1 
ATOM   1892 C CZ3 . TRP B 2 41  ? -9.478  -3.927  -0.508  1.00 19.66  ? 41  TRP B CZ3 1 
ATOM   1893 C CH2 . TRP B 2 41  ? -8.217  -4.088  -1.098  1.00 18.88  ? 41  TRP B CH2 1 
ATOM   1894 N N   . TYR B 2 42  ? -14.986 -1.879  -1.445  1.00 20.78  ? 42  TYR B N   1 
ATOM   1895 C CA  . TYR B 2 42  ? -16.224 -1.608  -0.724  1.00 20.32  ? 42  TYR B CA  1 
ATOM   1896 C C   . TYR B 2 42  ? -15.982 -1.452  0.786   1.00 22.88  ? 42  TYR B C   1 
ATOM   1897 O O   . TYR B 2 42  ? -15.132 -2.132  1.362   1.00 22.67  ? 42  TYR B O   1 
ATOM   1898 C CB  . TYR B 2 42  ? -17.233 -2.744  -0.926  1.00 20.00  ? 42  TYR B CB  1 
ATOM   1899 C CG  . TYR B 2 42  ? -17.789 -2.884  -2.322  1.00 22.23  ? 42  TYR B CG  1 
ATOM   1900 C CD1 . TYR B 2 42  ? -17.107 -3.600  -3.299  1.00 23.25  ? 42  TYR B CD1 1 
ATOM   1901 C CD2 . TYR B 2 42  ? -18.959 -2.245  -2.699  1.00 22.17  ? 42  TYR B CD2 1 
ATOM   1902 C CE1 . TYR B 2 42  ? -17.582 -3.705  -4.596  1.00 20.41  ? 42  TYR B CE1 1 
ATOM   1903 C CE2 . TYR B 2 42  ? -19.461 -2.350  -3.986  1.00 20.46  ? 42  TYR B CE2 1 
ATOM   1904 C CZ  . TYR B 2 42  ? -18.759 -3.059  -4.945  1.00 21.58  ? 42  TYR B CZ  1 
ATOM   1905 O OH  . TYR B 2 42  ? -19.288 -3.194  -6.206  1.00 18.20  ? 42  TYR B OH  1 
ATOM   1906 N N   . GLN B 2 43  ? -16.798 -0.592  1.424   1.00 20.87  ? 43  GLN B N   1 
ATOM   1907 C CA  . GLN B 2 43  ? -16.827 -0.372  2.858   1.00 21.36  ? 43  GLN B CA  1 
ATOM   1908 C C   . GLN B 2 43  ? -18.174 -0.823  3.382   1.00 22.03  ? 43  GLN B C   1 
ATOM   1909 O O   . GLN B 2 43  ? -19.183 -0.284  2.946   1.00 20.69  ? 43  GLN B O   1 
ATOM   1910 C CB  . GLN B 2 43  ? -16.711 1.126   3.161   1.00 23.90  ? 43  GLN B CB  1 
ATOM   1911 C CG  . GLN B 2 43  ? -16.787 1.512   4.640   1.00 25.27  ? 43  GLN B CG  1 
ATOM   1912 C CD  . GLN B 2 43  ? -16.901 3.010   4.776   1.00 26.02  ? 43  GLN B CD  1 
ATOM   1913 O OE1 . GLN B 2 43  ? -17.959 3.602   4.579   1.00 30.39  ? 43  GLN B OE1 1 
ATOM   1914 N NE2 . GLN B 2 43  ? -15.787 3.645   5.075   1.00 28.36  ? 43  GLN B NE2 1 
ATOM   1915 N N   . GLN B 2 44  ? -18.189 -1.788  4.303   1.00 23.68  ? 44  GLN B N   1 
ATOM   1916 C CA  . GLN B 2 44  ? -19.429 -2.197  4.933   1.00 23.79  ? 44  GLN B CA  1 
ATOM   1917 C C   . GLN B 2 44  ? -19.362 -1.972  6.444   1.00 27.93  ? 44  GLN B C   1 
ATOM   1918 O O   . GLN B 2 44  ? -18.466 -2.485  7.119   1.00 25.83  ? 44  GLN B O   1 
ATOM   1919 C CB  . GLN B 2 44  ? -19.751 -3.655  4.640   1.00 22.65  ? 44  GLN B CB  1 
ATOM   1920 C CG  . GLN B 2 44  ? -21.157 -4.034  5.073   1.00 21.18  ? 44  GLN B CG  1 
ATOM   1921 C CD  . GLN B 2 44  ? -21.455 -5.492  4.855   1.00 21.21  ? 44  GLN B CD  1 
ATOM   1922 O OE1 . GLN B 2 44  ? -20.570 -6.337  4.963   1.00 21.41  ? 44  GLN B OE1 1 
ATOM   1923 N NE2 . GLN B 2 44  ? -22.708 -5.809  4.538   1.00 22.32  ? 44  GLN B NE2 1 
ATOM   1924 N N   . LYS B 2 45  ? -20.343 -1.197  6.928   1.00 30.41  ? 45  LYS B N   1 
ATOM   1925 C CA  . LYS B 2 45  ? -20.640 -0.988  8.336   1.00 32.75  ? 45  LYS B CA  1 
ATOM   1926 C C   . LYS B 2 45  ? -21.877 -1.803  8.710   1.00 34.46  ? 45  LYS B C   1 
ATOM   1927 O O   . LYS B 2 45  ? -22.636 -2.187  7.841   1.00 32.90  ? 45  LYS B O   1 
ATOM   1928 C CB  . LYS B 2 45  ? -20.889 0.499   8.584   1.00 34.10  ? 45  LYS B CB  1 
ATOM   1929 C CG  . LYS B 2 45  ? -19.688 1.388   8.323   1.00 34.07  ? 45  LYS B CG  1 
ATOM   1930 C CD  . LYS B 2 45  ? -19.945 2.841   8.554   1.00 38.04  ? 45  LYS B CD  1 
ATOM   1931 C CE  . LYS B 2 45  ? -18.758 3.671   8.117   1.00 42.01  ? 45  LYS B CE  1 
ATOM   1932 N NZ  . LYS B 2 45  ? -18.898 5.082   8.539   1.00 45.69  ? 45  LYS B NZ  1 
ATOM   1933 N N   . PRO B 2 46  ? -22.112 -2.122  10.006  1.00 38.86  ? 46  PRO B N   1 
ATOM   1934 C CA  . PRO B 2 46  ? -23.111 -3.129  10.375  1.00 37.34  ? 46  PRO B CA  1 
ATOM   1935 C C   . PRO B 2 46  ? -24.546 -2.681  10.101  1.00 37.84  ? 46  PRO B C   1 
ATOM   1936 O O   . PRO B 2 46  ? -24.855 -1.495  10.149  1.00 36.37  ? 46  PRO B O   1 
ATOM   1937 C CB  . PRO B 2 46  ? -22.882 -3.338  11.881  1.00 41.79  ? 46  PRO B CB  1 
ATOM   1938 C CG  . PRO B 2 46  ? -21.513 -2.708  12.150  1.00 41.29  ? 46  PRO B CG  1 
ATOM   1939 C CD  . PRO B 2 46  ? -21.409 -1.562  11.171  1.00 37.51  ? 46  PRO B CD  1 
ATOM   1940 N N   . GLY B 2 47  ? -25.410 -3.636  9.747   1.00 38.05  ? 47  GLY B N   1 
ATOM   1941 C CA  . GLY B 2 47  ? -26.788 -3.331  9.393   1.00 38.74  ? 47  GLY B CA  1 
ATOM   1942 C C   . GLY B 2 47  ? -26.945 -2.802  7.968   1.00 41.72  ? 47  GLY B C   1 
ATOM   1943 O O   . GLY B 2 47  ? -28.059 -2.757  7.468   1.00 40.19  ? 47  GLY B O   1 
ATOM   1944 N N   . GLN B 2 48  ? -25.837 -2.431  7.307   1.00 41.37  ? 48  GLN B N   1 
ATOM   1945 C CA  . GLN B 2 48  ? -25.892 -1.763  6.017   1.00 39.33  ? 48  GLN B CA  1 
ATOM   1946 C C   . GLN B 2 48  ? -25.401 -2.668  4.880   1.00 38.82  ? 48  GLN B C   1 
ATOM   1947 O O   . GLN B 2 48  ? -24.630 -3.616  5.065   1.00 38.53  ? 48  GLN B O   1 
ATOM   1948 C CB  . GLN B 2 48  ? -25.032 -0.499  6.030   1.00 41.30  ? 48  GLN B CB  1 
ATOM   1949 C CG  . GLN B 2 48  ? -25.429 0.522   7.088   1.00 43.98  ? 48  GLN B CG  1 
ATOM   1950 C CD  . GLN B 2 48  ? -24.588 1.778   7.073   1.00 48.83  ? 48  GLN B CD  1 
ATOM   1951 O OE1 . GLN B 2 48  ? -24.745 2.659   7.911   1.00 53.11  ? 48  GLN B OE1 1 
ATOM   1952 N NE2 . GLN B 2 48  ? -23.657 1.884   6.140   1.00 52.07  ? 48  GLN B NE2 1 
ATOM   1953 N N   . PRO B 2 49  ? -25.826 -2.389  3.630   1.00 36.87  ? 49  PRO B N   1 
ATOM   1954 C CA  . PRO B 2 49  ? -25.159 -2.961  2.467   1.00 34.16  ? 49  PRO B CA  1 
ATOM   1955 C C   . PRO B 2 49  ? -23.746 -2.396  2.304   1.00 29.43  ? 49  PRO B C   1 
ATOM   1956 O O   . PRO B 2 49  ? -23.422 -1.318  2.788   1.00 29.30  ? 49  PRO B O   1 
ATOM   1957 C CB  . PRO B 2 49  ? -26.034 -2.482  1.312   1.00 33.35  ? 49  PRO B CB  1 
ATOM   1958 C CG  . PRO B 2 49  ? -26.596 -1.172  1.818   1.00 34.62  ? 49  PRO B CG  1 
ATOM   1959 C CD  . PRO B 2 49  ? -26.929 -1.484  3.258   1.00 35.64  ? 49  PRO B CD  1 
ATOM   1960 N N   . PRO B 2 50  ? -22.854 -3.086  1.581   1.00 27.58  ? 50  PRO B N   1 
ATOM   1961 C CA  . PRO B 2 50  ? -21.554 -2.509  1.262   1.00 26.91  ? 50  PRO B CA  1 
ATOM   1962 C C   . PRO B 2 50  ? -21.768 -1.281  0.401   1.00 25.05  ? 50  PRO B C   1 
ATOM   1963 O O   . PRO B 2 50  ? -22.680 -1.261  -0.394  1.00 24.50  ? 50  PRO B O   1 
ATOM   1964 C CB  . PRO B 2 50  ? -20.821 -3.629  0.527   1.00 27.25  ? 50  PRO B CB  1 
ATOM   1965 C CG  . PRO B 2 50  ? -21.902 -4.590  0.082   1.00 27.70  ? 50  PRO B CG  1 
ATOM   1966 C CD  . PRO B 2 50  ? -23.020 -4.457  1.088   1.00 27.87  ? 50  PRO B CD  1 
ATOM   1967 N N   . LYS B 2 51  ? -20.892 -0.299  0.574   1.00 27.29  ? 51  LYS B N   1 
ATOM   1968 C CA  . LYS B 2 51  ? -20.884 0.948   -0.162  1.00 28.71  ? 51  LYS B CA  1 
ATOM   1969 C C   . LYS B 2 51  ? -19.580 1.017   -0.956  1.00 28.36  ? 51  LYS B C   1 
ATOM   1970 O O   . LYS B 2 51  ? -18.477 0.749   -0.440  1.00 22.51  ? 51  LYS B O   1 
ATOM   1971 C CB  . LYS B 2 51  ? -21.080 2.094   0.836   1.00 36.55  ? 51  LYS B CB  1 
ATOM   1972 C CG  . LYS B 2 51  ? -20.567 3.458   0.391   1.00 45.85  ? 51  LYS B CG  1 
ATOM   1973 C CD  . LYS B 2 51  ? -21.075 4.608   1.293   1.00 50.21  ? 51  LYS B CD  1 
ATOM   1974 C CE  . LYS B 2 51  ? -20.389 5.943   1.048   1.00 50.60  ? 51  LYS B CE  1 
ATOM   1975 N NZ  . LYS B 2 51  ? -19.052 6.000   1.689   1.00 51.46  ? 51  LYS B NZ  1 
ATOM   1976 N N   . LEU B 2 52  ? -19.740 1.328   -2.243  1.00 26.98  ? 52  LEU B N   1 
ATOM   1977 C CA  . LEU B 2 52  ? -18.650 1.303   -3.197  1.00 25.90  ? 52  LEU B CA  1 
ATOM   1978 C C   . LEU B 2 52  ? -17.779 2.515   -2.948  1.00 22.91  ? 52  LEU B C   1 
ATOM   1979 O O   . LEU B 2 52  ? -18.281 3.621   -2.888  1.00 25.64  ? 52  LEU B O   1 
ATOM   1980 C CB  . LEU B 2 52  ? -19.240 1.310   -4.612  1.00 26.54  ? 52  LEU B CB  1 
ATOM   1981 C CG  . LEU B 2 52  ? -18.254 1.535   -5.757  1.00 27.08  ? 52  LEU B CG  1 
ATOM   1982 C CD1 . LEU B 2 52  ? -17.286 0.346   -5.899  1.00 25.12  ? 52  LEU B CD1 1 
ATOM   1983 C CD2 . LEU B 2 52  ? -19.013 1.762   -7.057  1.00 25.87  ? 52  LEU B CD2 1 
ATOM   1984 N N   . LEU B 2 53  ? -16.469 2.295   -2.829  1.00 22.80  ? 53  LEU B N   1 
ATOM   1985 C CA  . LEU B 2 53  ? -15.519 3.380   -2.638  1.00 22.10  ? 53  LEU B CA  1 
ATOM   1986 C C   . LEU B 2 53  ? -14.695 3.661   -3.889  1.00 22.98  ? 53  LEU B C   1 
ATOM   1987 O O   . LEU B 2 53  ? -14.421 4.823   -4.190  1.00 21.80  ? 53  LEU B O   1 
ATOM   1988 C CB  . LEU B 2 53  ? -14.547 2.943   -1.556  1.00 25.09  ? 53  LEU B CB  1 
ATOM   1989 C CG  . LEU B 2 53  ? -15.146 2.640   -0.190  1.00 25.98  ? 53  LEU B CG  1 
ATOM   1990 C CD1 . LEU B 2 53  ? -14.059 2.052   0.688   1.00 25.76  ? 53  LEU B CD1 1 
ATOM   1991 C CD2 . LEU B 2 53  ? -15.732 3.901   0.432   1.00 26.34  ? 53  LEU B CD2 1 
ATOM   1992 N N   . ILE B 2 54  ? -14.178 2.583   -4.511  1.00 19.78  ? 54  ILE B N   1 
ATOM   1993 C CA  . ILE B 2 54  ? -13.202 2.675   -5.581  1.00 19.26  ? 54  ILE B CA  1 
ATOM   1994 C C   . ILE B 2 54  ? -13.599 1.664   -6.651  1.00 16.44  ? 54  ILE B C   1 
ATOM   1995 O O   . ILE B 2 54  ? -14.001 0.548   -6.319  1.00 16.78  ? 54  ILE B O   1 
ATOM   1996 C CB  . ILE B 2 54  ? -11.776 2.359   -5.052  1.00 21.30  ? 54  ILE B CB  1 
ATOM   1997 C CG1 . ILE B 2 54  ? -11.352 3.167   -3.820  1.00 19.76  ? 54  ILE B CG1 1 
ATOM   1998 C CG2 . ILE B 2 54  ? -10.734 2.438   -6.159  1.00 21.06  ? 54  ILE B CG2 1 
ATOM   1999 C CD1 . ILE B 2 54  ? -11.024 4.596   -4.097  1.00 19.90  ? 54  ILE B CD1 1 
ATOM   2000 N N   . TYR B 2 55  ? -13.436 2.023   -7.930  1.00 16.23  ? 55  TYR B N   1 
ATOM   2001 C CA  . TYR B 2 55  ? -13.606 1.062   -9.019  1.00 16.47  ? 55  TYR B CA  1 
ATOM   2002 C C   . TYR B 2 55  ? -12.588 1.369   -10.109 1.00 16.48  ? 55  TYR B C   1 
ATOM   2003 O O   . TYR B 2 55  ? -11.890 2.355   -10.017 1.00 15.71  ? 55  TYR B O   1 
ATOM   2004 C CB  . TYR B 2 55  ? -15.049 1.033   -9.515  1.00 16.61  ? 55  TYR B CB  1 
ATOM   2005 C CG  . TYR B 2 55  ? -15.552 2.359   -10.012 1.00 18.08  ? 55  TYR B CG  1 
ATOM   2006 C CD1 . TYR B 2 55  ? -15.351 2.745   -11.326 1.00 19.23  ? 55  TYR B CD1 1 
ATOM   2007 C CD2 . TYR B 2 55  ? -16.150 3.267   -9.147  1.00 19.01  ? 55  TYR B CD2 1 
ATOM   2008 C CE1 . TYR B 2 55  ? -15.747 3.995   -11.783 1.00 19.63  ? 55  TYR B CE1 1 
ATOM   2009 C CE2 . TYR B 2 55  ? -16.569 4.512   -9.594  1.00 21.30  ? 55  TYR B CE2 1 
ATOM   2010 C CZ  . TYR B 2 55  ? -16.378 4.869   -10.923 1.00 20.57  ? 55  TYR B CZ  1 
ATOM   2011 O OH  . TYR B 2 55  ? -16.769 6.085   -11.383 1.00 21.75  ? 55  TYR B OH  1 
ATOM   2012 N N   . TRP B 2 56  ? -12.491 0.492   -11.113 1.00 16.69  ? 56  TRP B N   1 
ATOM   2013 C CA  . TRP B 2 56  ? -11.388 0.476   -12.049 1.00 17.42  ? 56  TRP B CA  1 
ATOM   2014 C C   . TRP B 2 56  ? -10.032 0.578   -11.326 1.00 17.11  ? 56  TRP B C   1 
ATOM   2015 O O   . TRP B 2 56  ? -9.091  1.144   -11.885 1.00 15.97  ? 56  TRP B O   1 
ATOM   2016 C CB  . TRP B 2 56  ? -11.554 1.560   -13.143 1.00 19.28  ? 56  TRP B CB  1 
ATOM   2017 C CG  . TRP B 2 56  ? -12.836 1.453   -13.917 1.00 20.11  ? 56  TRP B CG  1 
ATOM   2018 C CD1 . TRP B 2 56  ? -13.784 2.419   -14.070 1.00 19.37  ? 56  TRP B CD1 1 
ATOM   2019 C CD2 . TRP B 2 56  ? -13.333 0.298   -14.625 1.00 21.21  ? 56  TRP B CD2 1 
ATOM   2020 N NE1 . TRP B 2 56  ? -14.835 1.945   -14.813 1.00 21.41  ? 56  TRP B NE1 1 
ATOM   2021 C CE2 . TRP B 2 56  ? -14.589 0.647   -15.173 1.00 22.70  ? 56  TRP B CE2 1 
ATOM   2022 C CE3 . TRP B 2 56  ? -12.840 -0.989  -14.859 1.00 21.66  ? 56  TRP B CE3 1 
ATOM   2023 C CZ2 . TRP B 2 56  ? -15.355 -0.248  -15.929 1.00 22.98  ? 56  TRP B CZ2 1 
ATOM   2024 C CZ3 . TRP B 2 56  ? -13.560 -1.850  -15.654 1.00 22.03  ? 56  TRP B CZ3 1 
ATOM   2025 C CH2 . TRP B 2 56  ? -14.819 -1.498  -16.153 1.00 22.62  ? 56  TRP B CH2 1 
ATOM   2026 N N   . ALA B 2 57  ? -9.949  0.029   -10.100 1.00 17.45  ? 57  ALA B N   1 
ATOM   2027 C CA  . ALA B 2 57  ? -8.759  0.013   -9.237  1.00 19.26  ? 57  ALA B CA  1 
ATOM   2028 C C   . ALA B 2 57  ? -8.438  1.351   -8.557  1.00 22.09  ? 57  ALA B C   1 
ATOM   2029 O O   . ALA B 2 57  ? -7.903  1.344   -7.446  1.00 23.94  ? 57  ALA B O   1 
ATOM   2030 C CB  . ALA B 2 57  ? -7.527  -0.469  -9.961  1.00 18.68  ? 57  ALA B CB  1 
ATOM   2031 N N   . SER B 2 58  ? -8.686  2.486   -9.219  1.00 22.79  ? 58  SER B N   1 
ATOM   2032 C CA  . SER B 2 58  ? -8.126  3.746   -8.761  1.00 24.65  ? 58  SER B CA  1 
ATOM   2033 C C   . SER B 2 58  ? -9.088  4.923   -8.940  1.00 24.98  ? 58  SER B C   1 
ATOM   2034 O O   . SER B 2 58  ? -8.742  6.039   -8.557  1.00 26.34  ? 58  SER B O   1 
ATOM   2035 C CB  . SER B 2 58  ? -6.838  4.015   -9.468  1.00 23.32  ? 58  SER B CB  1 
ATOM   2036 O OG  . SER B 2 58  ? -7.039  4.033   -10.863 1.00 24.23  ? 58  SER B OG  1 
ATOM   2037 N N   . THR B 2 59  ? -10.288 4.683   -9.485  1.00 22.61  ? 59  THR B N   1 
ATOM   2038 C CA  . THR B 2 59  ? -11.258 5.745   -9.654  1.00 22.53  ? 59  THR B CA  1 
ATOM   2039 C C   . THR B 2 59  ? -12.146 5.803   -8.412  1.00 24.05  ? 59  THR B C   1 
ATOM   2040 O O   . THR B 2 59  ? -12.798 4.819   -8.078  1.00 23.81  ? 59  THR B O   1 
ATOM   2041 C CB  . THR B 2 59  ? -12.117 5.541   -10.909 1.00 23.86  ? 59  THR B CB  1 
ATOM   2042 O OG1 . THR B 2 59  ? -11.312 5.664   -12.085 1.00 21.88  ? 59  THR B OG1 1 
ATOM   2043 C CG2 . THR B 2 59  ? -13.263 6.536   -10.954 1.00 23.63  ? 59  THR B CG2 1 
ATOM   2044 N N   . ARG B 2 60  ? -12.170 6.976   -7.756  1.00 24.10  ? 60  ARG B N   1 
ATOM   2045 C CA  . ARG B 2 60  ? -12.912 7.183   -6.525  1.00 27.19  ? 60  ARG B CA  1 
ATOM   2046 C C   . ARG B 2 60  ? -14.377 7.497   -6.835  1.00 24.47  ? 60  ARG B C   1 
ATOM   2047 O O   . ARG B 2 60  ? -14.672 8.355   -7.644  1.00 24.75  ? 60  ARG B O   1 
ATOM   2048 C CB  . ARG B 2 60  ? -12.224 8.303   -5.738  1.00 30.57  ? 60  ARG B CB  1 
ATOM   2049 C CG  . ARG B 2 60  ? -12.880 8.641   -4.411  1.00 33.24  ? 60  ARG B CG  1 
ATOM   2050 C CD  . ARG B 2 60  ? -12.009 9.552   -3.567  1.00 37.02  ? 60  ARG B CD  1 
ATOM   2051 N NE  . ARG B 2 60  ? -11.368 10.573  -4.387  1.00 38.44  ? 60  ARG B NE  1 
ATOM   2052 C CZ  . ARG B 2 60  ? -10.059 10.646  -4.625  1.00 47.55  ? 60  ARG B CZ  1 
ATOM   2053 N NH1 . ARG B 2 60  ? -9.200  9.875   -3.975  1.00 50.06  ? 60  ARG B NH1 1 
ATOM   2054 N NH2 . ARG B 2 60  ? -9.597  11.523  -5.500  1.00 51.36  ? 60  ARG B NH2 1 
ATOM   2055 N N   . GLU B 2 61  ? -15.295 6.760   -6.223  1.00 25.79  ? 61  GLU B N   1 
ATOM   2056 C CA  . GLU B 2 61  ? -16.724 6.975   -6.415  1.00 28.75  ? 61  GLU B CA  1 
ATOM   2057 C C   . GLU B 2 61  ? -17.123 8.349   -5.872  1.00 30.50  ? 61  GLU B C   1 
ATOM   2058 O O   . GLU B 2 61  ? -16.602 8.817   -4.862  1.00 33.01  ? 61  GLU B O   1 
ATOM   2059 C CB  . GLU B 2 61  ? -17.499 5.848   -5.726  1.00 27.80  ? 61  GLU B CB  1 
ATOM   2060 C CG  . GLU B 2 61  ? -19.007 6.060   -5.623  1.00 30.17  ? 61  GLU B CG  1 
ATOM   2061 C CD  . GLU B 2 61  ? -19.817 6.005   -6.907  1.00 31.76  ? 61  GLU B CD  1 
ATOM   2062 O OE1 . GLU B 2 61  ? -19.242 5.879   -7.992  1.00 35.45  ? 61  GLU B OE1 1 
ATOM   2063 O OE2 . GLU B 2 61  ? -21.034 6.060   -6.813  1.00 31.68  ? 61  GLU B OE2 1 
ATOM   2064 N N   . SER B 2 62  ? -18.072 8.987   -6.550  1.00 34.29  ? 62  SER B N   1 
ATOM   2065 C CA  . SER B 2 62  ? -18.622 10.270  -6.134  1.00 36.46  ? 62  SER B CA  1 
ATOM   2066 C C   . SER B 2 62  ? -18.998 10.300  -4.656  1.00 32.29  ? 62  SER B C   1 
ATOM   2067 O O   . SER B 2 62  ? -19.648 9.394   -4.142  1.00 33.80  ? 62  SER B O   1 
ATOM   2068 C CB  . SER B 2 62  ? -19.833 10.599  -6.962  1.00 39.17  ? 62  SER B CB  1 
ATOM   2069 O OG  . SER B 2 62  ? -19.502 10.587  -8.334  1.00 40.92  ? 62  SER B OG  1 
ATOM   2070 N N   . GLY B 2 63  ? -18.633 11.399  -3.997  1.00 34.56  ? 63  GLY B N   1 
ATOM   2071 C CA  . GLY B 2 63  ? -19.021 11.634  -2.621  1.00 35.62  ? 63  GLY B CA  1 
ATOM   2072 C C   . GLY B 2 63  ? -18.056 10.980  -1.636  1.00 40.25  ? 63  GLY B C   1 
ATOM   2073 O O   . GLY B 2 63  ? -18.166 11.207  -0.429  1.00 44.12  ? 63  GLY B O   1 
ATOM   2074 N N   . VAL B 2 64  ? -17.121 10.154  -2.137  1.00 36.33  ? 64  VAL B N   1 
ATOM   2075 C CA  . VAL B 2 64  ? -16.195 9.474   -1.246  1.00 34.94  ? 64  VAL B CA  1 
ATOM   2076 C C   . VAL B 2 64  ? -15.054 10.440  -0.952  1.00 31.15  ? 64  VAL B C   1 
ATOM   2077 O O   . VAL B 2 64  ? -14.479 11.005  -1.870  1.00 30.80  ? 64  VAL B O   1 
ATOM   2078 C CB  . VAL B 2 64  ? -15.661 8.142   -1.815  1.00 35.77  ? 64  VAL B CB  1 
ATOM   2079 C CG1 . VAL B 2 64  ? -14.707 7.466   -0.834  1.00 35.84  ? 64  VAL B CG1 1 
ATOM   2080 C CG2 . VAL B 2 64  ? -16.779 7.180   -2.185  1.00 34.80  ? 64  VAL B CG2 1 
ATOM   2081 N N   . PRO B 2 65  ? -14.647 10.612  0.325   1.00 34.39  ? 65  PRO B N   1 
ATOM   2082 C CA  . PRO B 2 65  ? -13.584 11.556  0.672   1.00 34.85  ? 65  PRO B CA  1 
ATOM   2083 C C   . PRO B 2 65  ? -12.237 11.193  0.039   1.00 34.84  ? 65  PRO B C   1 
ATOM   2084 O O   . PRO B 2 65  ? -11.947 10.010  -0.133  1.00 37.57  ? 65  PRO B O   1 
ATOM   2085 C CB  . PRO B 2 65  ? -13.507 11.458  2.211   1.00 35.74  ? 65  PRO B CB  1 
ATOM   2086 C CG  . PRO B 2 65  ? -14.816 10.831  2.643   1.00 35.57  ? 65  PRO B CG  1 
ATOM   2087 C CD  . PRO B 2 65  ? -15.173 9.901   1.501   1.00 36.18  ? 65  PRO B CD  1 
ATOM   2088 N N   . ASP B 2 66  ? -11.410 12.221  -0.204  1.00 33.05  ? 66  ASP B N   1 
ATOM   2089 C CA  . ASP B 2 66  ? -10.124 12.158  -0.884  1.00 36.11  ? 66  ASP B CA  1 
ATOM   2090 C C   . ASP B 2 66  ? -9.108  11.312  -0.128  1.00 35.01  ? 66  ASP B C   1 
ATOM   2091 O O   . ASP B 2 66  ? -8.052  10.992  -0.657  1.00 30.15  ? 66  ASP B O   1 
ATOM   2092 C CB  . ASP B 2 66  ? -9.470  13.541  -0.981  1.00 46.31  ? 66  ASP B CB  1 
ATOM   2093 C CG  . ASP B 2 66  ? -10.089 14.453  -2.025  1.00 61.47  ? 66  ASP B CG  1 
ATOM   2094 O OD1 . ASP B 2 66  ? -11.126 14.066  -2.591  1.00 74.54  ? 66  ASP B OD1 1 
ATOM   2095 O OD2 . ASP B 2 66  ? -9.517  15.537  -2.285  1.00 67.73  ? 66  ASP B OD2 1 
ATOM   2096 N N   . ARG B 2 67  ? -9.388  10.999  1.134   1.00 33.09  ? 67  ARG B N   1 
ATOM   2097 C CA  . ARG B 2 67  ? -8.419  10.258  1.911   1.00 31.03  ? 67  ARG B CA  1 
ATOM   2098 C C   . ARG B 2 67  ? -8.416  8.789   1.471   1.00 30.74  ? 67  ARG B C   1 
ATOM   2099 O O   . ARG B 2 67  ? -7.431  8.084   1.701   1.00 25.34  ? 67  ARG B O   1 
ATOM   2100 C CB  . ARG B 2 67  ? -8.639  10.516  3.407   1.00 31.46  ? 67  ARG B CB  1 
ATOM   2101 C CG  . ARG B 2 67  ? -9.916  9.967   4.014   1.00 33.54  ? 67  ARG B CG  1 
ATOM   2102 C CD  . ARG B 2 67  ? -9.946  10.231  5.516   1.00 32.80  ? 67  ARG B CD  1 
ATOM   2103 N NE  . ARG B 2 67  ? -11.166 9.710   6.120   1.00 32.35  ? 67  ARG B NE  1 
ATOM   2104 C CZ  . ARG B 2 67  ? -12.363 10.274  6.006   1.00 34.45  ? 67  ARG B CZ  1 
ATOM   2105 N NH1 . ARG B 2 67  ? -12.479 11.478  5.479   1.00 39.34  ? 67  ARG B NH1 1 
ATOM   2106 N NH2 . ARG B 2 67  ? -13.445 9.659   6.458   1.00 35.66  ? 67  ARG B NH2 1 
ATOM   2107 N N   . PHE B 2 68  ? -9.494  8.335   0.813   1.00 30.88  ? 68  PHE B N   1 
ATOM   2108 C CA  . PHE B 2 68  ? -9.505  6.991   0.267   1.00 28.39  ? 68  PHE B CA  1 
ATOM   2109 C C   . PHE B 2 68  ? -8.890  7.047   -1.124  1.00 27.31  ? 68  PHE B C   1 
ATOM   2110 O O   . PHE B 2 68  ? -9.324  7.849   -1.929  1.00 27.40  ? 68  PHE B O   1 
ATOM   2111 C CB  . PHE B 2 68  ? -10.908 6.397   0.175   1.00 25.89  ? 68  PHE B CB  1 
ATOM   2112 C CG  . PHE B 2 68  ? -11.606 6.214   1.499   1.00 28.97  ? 68  PHE B CG  1 
ATOM   2113 C CD1 . PHE B 2 68  ? -12.297 7.264   2.097   1.00 28.96  ? 68  PHE B CD1 1 
ATOM   2114 C CD2 . PHE B 2 68  ? -11.593 4.983   2.144   1.00 28.93  ? 68  PHE B CD2 1 
ATOM   2115 C CE1 . PHE B 2 68  ? -12.938 7.090   3.319   1.00 27.49  ? 68  PHE B CE1 1 
ATOM   2116 C CE2 . PHE B 2 68  ? -12.208 4.814   3.377   1.00 29.01  ? 68  PHE B CE2 1 
ATOM   2117 C CZ  . PHE B 2 68  ? -12.888 5.869   3.958   1.00 31.48  ? 68  PHE B CZ  1 
ATOM   2118 N N   . SER B 2 69  ? -7.903  6.183   -1.390  1.00 24.22  ? 69  SER B N   1 
ATOM   2119 C CA  . SER B 2 69  ? -7.452  5.952   -2.748  1.00 25.75  ? 69  SER B CA  1 
ATOM   2120 C C   . SER B 2 69  ? -7.166  4.461   -2.955  1.00 26.32  ? 69  SER B C   1 
ATOM   2121 O O   . SER B 2 69  ? -6.945  3.719   -2.009  1.00 26.83  ? 69  SER B O   1 
ATOM   2122 C CB  . SER B 2 69  ? -6.251  6.824   -3.091  1.00 26.78  ? 69  SER B CB  1 
ATOM   2123 O OG  . SER B 2 69  ? -5.113  6.469   -2.325  1.00 25.33  ? 69  SER B OG  1 
ATOM   2124 N N   . GLY B 2 70  ? -7.248  4.029   -4.217  1.00 27.04  ? 70  GLY B N   1 
ATOM   2125 C CA  . GLY B 2 70  ? -6.921  2.686   -4.643  1.00 24.04  ? 70  GLY B CA  1 
ATOM   2126 C C   . GLY B 2 70  ? -5.789  2.776   -5.651  1.00 23.03  ? 70  GLY B C   1 
ATOM   2127 O O   . GLY B 2 70  ? -5.727  3.740   -6.416  1.00 23.18  ? 70  GLY B O   1 
ATOM   2128 N N   . SER B 2 71  ? -4.867  1.816   -5.610  1.00 21.99  ? 71  SER B N   1 
ATOM   2129 C CA  . SER B 2 71  ? -3.909  1.683   -6.700  1.00 22.67  ? 71  SER B CA  1 
ATOM   2130 C C   . SER B 2 71  ? -3.532  0.217   -6.870  1.00 19.47  ? 71  SER B C   1 
ATOM   2131 O O   . SER B 2 71  ? -4.171  -0.666  -6.280  1.00 19.61  ? 71  SER B O   1 
ATOM   2132 C CB  . SER B 2 71  ? -2.707  2.601   -6.531  1.00 24.79  ? 71  SER B CB  1 
ATOM   2133 O OG  . SER B 2 71  ? -1.982  2.283   -5.359  1.00 24.71  ? 71  SER B OG  1 
ATOM   2134 N N   . GLY B 2 72  ? -2.554  -0.009  -7.749  1.00 18.94  ? 72  GLY B N   1 
ATOM   2135 C CA  . GLY B 2 72  ? -2.087  -1.327  -8.134  1.00 19.34  ? 72  GLY B CA  1 
ATOM   2136 C C   . GLY B 2 72  ? -2.650  -1.770  -9.488  1.00 20.51  ? 72  GLY B C   1 
ATOM   2137 O O   . GLY B 2 72  ? -3.467  -1.086  -10.095 1.00 19.63  ? 72  GLY B O   1 
ATOM   2138 N N   . SER B 2 73  ? -2.217  -2.946  -9.950  1.00 21.02  ? 73  SER B N   1 
ATOM   2139 C CA  . SER B 2 73  ? -2.522  -3.362  -11.301 1.00 22.86  ? 73  SER B CA  1 
ATOM   2140 C C   . SER B 2 73  ? -2.304  -4.854  -11.458 1.00 23.26  ? 73  SER B C   1 
ATOM   2141 O O   . SER B 2 73  ? -1.525  -5.463  -10.737 1.00 20.43  ? 73  SER B O   1 
ATOM   2142 C CB  . SER B 2 73  ? -1.733  -2.589  -12.323 1.00 23.67  ? 73  SER B CB  1 
ATOM   2143 O OG  . SER B 2 73  ? -2.223  -2.905  -13.634 1.00 22.41  ? 73  SER B OG  1 
ATOM   2144 N N   . GLY B 2 74  ? -3.064  -5.448  -12.385 1.00 24.40  ? 74  GLY B N   1 
ATOM   2145 C CA  . GLY B 2 74  ? -2.860  -6.838  -12.716 1.00 21.80  ? 74  GLY B CA  1 
ATOM   2146 C C   . GLY B 2 74  ? -3.468  -7.741  -11.663 1.00 22.16  ? 74  GLY B C   1 
ATOM   2147 O O   . GLY B 2 74  ? -4.656  -8.066  -11.775 1.00 20.74  ? 74  GLY B O   1 
ATOM   2148 N N   . THR B 2 75  ? -2.633  -8.154  -10.688 1.00 21.59  ? 75  THR B N   1 
ATOM   2149 C CA  . THR B 2 75  ? -3.036  -9.078  -9.637  1.00 23.10  ? 75  THR B CA  1 
ATOM   2150 C C   . THR B 2 75  ? -2.787  -8.543  -8.223  1.00 22.94  ? 75  THR B C   1 
ATOM   2151 O O   . THR B 2 75  ? -3.097  -9.239  -7.244  1.00 25.30  ? 75  THR B O   1 
ATOM   2152 C CB  . THR B 2 75  ? -2.275  -10.414 -9.725  1.00 28.00  ? 75  THR B CB  1 
ATOM   2153 O OG1 . THR B 2 75  ? -0.885  -10.113 -9.757  1.00 24.57  ? 75  THR B OG1 1 
ATOM   2154 C CG2 . THR B 2 75  ? -2.597  -11.239 -10.949 1.00 31.32  ? 75  THR B CG2 1 
ATOM   2155 N N   . ASP B 2 76  ? -2.174  -7.366  -8.079  1.00 22.93  ? 76  ASP B N   1 
ATOM   2156 C CA  . ASP B 2 76  ? -1.861  -6.848  -6.753  1.00 24.85  ? 76  ASP B CA  1 
ATOM   2157 C C   . ASP B 2 76  ? -2.372  -5.419  -6.626  1.00 22.55  ? 76  ASP B C   1 
ATOM   2158 O O   . ASP B 2 76  ? -2.001  -4.564  -7.430  1.00 24.01  ? 76  ASP B O   1 
ATOM   2159 C CB  . ASP B 2 76  ? -0.365  -6.808  -6.452  1.00 28.61  ? 76  ASP B CB  1 
ATOM   2160 C CG  . ASP B 2 76  ? 0.097   -7.897  -5.507  1.00 37.64  ? 76  ASP B CG  1 
ATOM   2161 O OD1 . ASP B 2 76  ? 0.359   -9.001  -5.992  1.00 48.60  ? 76  ASP B OD1 1 
ATOM   2162 O OD2 . ASP B 2 76  ? 0.166   -7.630  -4.283  1.00 47.85  ? 76  ASP B OD2 1 
ATOM   2163 N N   . PHE B 2 77  ? -3.108  -5.176  -5.540  1.00 19.27  ? 77  PHE B N   1 
ATOM   2164 C CA  . PHE B 2 77  ? -3.910  -3.981  -5.375  1.00 21.23  ? 77  PHE B CA  1 
ATOM   2165 C C   . PHE B 2 77  ? -3.834  -3.521  -3.933  1.00 21.21  ? 77  PHE B C   1 
ATOM   2166 O O   . PHE B 2 77  ? -3.698  -4.351  -3.035  1.00 24.05  ? 77  PHE B O   1 
ATOM   2167 C CB  . PHE B 2 77  ? -5.378  -4.234  -5.772  1.00 19.89  ? 77  PHE B CB  1 
ATOM   2168 C CG  . PHE B 2 77  ? -5.537  -4.584  -7.232  1.00 19.02  ? 77  PHE B CG  1 
ATOM   2169 C CD1 . PHE B 2 77  ? -5.572  -3.595  -8.192  1.00 17.92  ? 77  PHE B CD1 1 
ATOM   2170 C CD2 . PHE B 2 77  ? -5.538  -5.907  -7.655  1.00 19.87  ? 77  PHE B CD2 1 
ATOM   2171 C CE1 . PHE B 2 77  ? -5.707  -3.912  -9.537  1.00 18.44  ? 77  PHE B CE1 1 
ATOM   2172 C CE2 . PHE B 2 77  ? -5.613  -6.220  -9.008  1.00 19.24  ? 77  PHE B CE2 1 
ATOM   2173 C CZ  . PHE B 2 77  ? -5.725  -5.219  -9.944  1.00 17.73  ? 77  PHE B CZ  1 
ATOM   2174 N N   . THR B 2 78  ? -4.021  -2.207  -3.765  1.00 21.08  ? 78  THR B N   1 
ATOM   2175 C CA  . THR B 2 78  ? -3.984  -1.549  -2.474  1.00 25.28  ? 78  THR B CA  1 
ATOM   2176 C C   . THR B 2 78  ? -5.142  -0.560  -2.317  1.00 23.54  ? 78  THR B C   1 
ATOM   2177 O O   . THR B 2 78  ? -5.394  0.258   -3.208  1.00 22.91  ? 78  THR B O   1 
ATOM   2178 C CB  . THR B 2 78  ? -2.637  -0.831  -2.310  1.00 25.85  ? 78  THR B CB  1 
ATOM   2179 O OG1 . THR B 2 78  ? -1.699  -1.798  -1.844  1.00 27.23  ? 78  THR B OG1 1 
ATOM   2180 C CG2 . THR B 2 78  ? -2.670  0.268   -1.287  1.00 31.73  ? 78  THR B CG2 1 
ATOM   2181 N N   . LEU B 2 79  ? -5.787  -0.616  -1.140  1.00 23.48  ? 79  LEU B N   1 
ATOM   2182 C CA  . LEU B 2 79  ? -6.626  0.464   -0.622  1.00 23.88  ? 79  LEU B CA  1 
ATOM   2183 C C   . LEU B 2 79  ? -5.895  1.227   0.492   1.00 26.21  ? 79  LEU B C   1 
ATOM   2184 O O   . LEU B 2 79  ? -5.490  0.634   1.488   1.00 27.29  ? 79  LEU B O   1 
ATOM   2185 C CB  . LEU B 2 79  ? -7.938  -0.117  -0.082  1.00 22.59  ? 79  LEU B CB  1 
ATOM   2186 C CG  . LEU B 2 79  ? -8.964  0.918   0.396   1.00 22.95  ? 79  LEU B CG  1 
ATOM   2187 C CD1 . LEU B 2 79  ? -9.594  1.673   -0.757  1.00 21.88  ? 79  LEU B CD1 1 
ATOM   2188 C CD2 . LEU B 2 79  ? -10.053 0.260   1.212   1.00 24.06  ? 79  LEU B CD2 1 
ATOM   2189 N N   . THR B 2 80  ? -5.841  2.555   0.346   1.00 27.91  ? 80  THR B N   1 
ATOM   2190 C CA  . THR B 2 80  ? -5.129  3.463   1.234   1.00 29.22  ? 80  THR B CA  1 
ATOM   2191 C C   . THR B 2 80  ? -6.115  4.496   1.774   1.00 26.84  ? 80  THR B C   1 
ATOM   2192 O O   . THR B 2 80  ? -6.741  5.206   1.005   1.00 24.76  ? 80  THR B O   1 
ATOM   2193 C CB  . THR B 2 80  ? -3.951  4.146   0.518   1.00 31.35  ? 80  THR B CB  1 
ATOM   2194 O OG1 . THR B 2 80  ? -3.004  3.148   0.134   1.00 31.88  ? 80  THR B OG1 1 
ATOM   2195 C CG2 . THR B 2 80  ? -3.222  5.157   1.371   1.00 38.44  ? 80  THR B CG2 1 
ATOM   2196 N N   . ILE B 2 81  ? -6.284  4.492   3.098   1.00 26.32  ? 81  ILE B N   1 
ATOM   2197 C CA  . ILE B 2 81  ? -6.839  5.593   3.852   1.00 29.97  ? 81  ILE B CA  1 
ATOM   2198 C C   . ILE B 2 81  ? -5.665  6.397   4.415   1.00 31.53  ? 81  ILE B C   1 
ATOM   2199 O O   . ILE B 2 81  ? -4.966  5.945   5.317   1.00 34.64  ? 81  ILE B O   1 
ATOM   2200 C CB  . ILE B 2 81  ? -7.787  5.074   4.949   1.00 32.86  ? 81  ILE B CB  1 
ATOM   2201 C CG1 . ILE B 2 81  ? -8.807  4.079   4.393   1.00 35.82  ? 81  ILE B CG1 1 
ATOM   2202 C CG2 . ILE B 2 81  ? -8.465  6.252   5.639   1.00 36.90  ? 81  ILE B CG2 1 
ATOM   2203 C CD1 . ILE B 2 81  ? -9.481  3.231   5.433   1.00 40.11  ? 81  ILE B CD1 1 
ATOM   2204 N N   . SER B 2 82  ? -5.432  7.581   3.842   1.00 33.85  ? 82  SER B N   1 
ATOM   2205 C CA  . SER B 2 82  ? -4.224  8.360   4.086   1.00 36.64  ? 82  SER B CA  1 
ATOM   2206 C C   . SER B 2 82  ? -4.147  8.853   5.534   1.00 39.45  ? 82  SER B C   1 
ATOM   2207 O O   . SER B 2 82  ? -3.067  8.870   6.133   1.00 41.02  ? 82  SER B O   1 
ATOM   2208 C CB  . SER B 2 82  ? -4.167  9.518   3.145   1.00 35.20  ? 82  SER B CB  1 
ATOM   2209 O OG  . SER B 2 82  ? -5.344  10.302  3.302   1.00 38.08  ? 82  SER B OG  1 
ATOM   2210 N N   . SER B 2 83  ? -5.288  9.282   6.087   1.00 38.23  ? 83  SER B N   1 
ATOM   2211 C CA  . SER B 2 83  ? -5.304  9.796   7.445   1.00 39.99  ? 83  SER B CA  1 
ATOM   2212 C C   . SER B 2 83  ? -6.584  9.343   8.147   1.00 36.61  ? 83  SER B C   1 
ATOM   2213 O O   . SER B 2 83  ? -7.636  9.947   7.992   1.00 37.22  ? 83  SER B O   1 
ATOM   2214 C CB  . SER B 2 83  ? -5.120  11.293  7.417   1.00 47.78  ? 83  SER B CB  1 
ATOM   2215 O OG  . SER B 2 83  ? -5.504  11.892  8.646   1.00 57.53  ? 83  SER B OG  1 
ATOM   2216 N N   . LEU B 2 84  ? -6.476  8.266   8.931   1.00 32.09  ? 84  LEU B N   1 
ATOM   2217 C CA  . LEU B 2 84  ? -7.636  7.511   9.370   1.00 33.30  ? 84  LEU B CA  1 
ATOM   2218 C C   . LEU B 2 84  ? -8.516  8.373   10.269  1.00 37.32  ? 84  LEU B C   1 
ATOM   2219 O O   . LEU B 2 84  ? -8.001  9.136   11.081  1.00 34.00  ? 84  LEU B O   1 
ATOM   2220 C CB  . LEU B 2 84  ? -7.151  6.263   10.116  1.00 29.76  ? 84  LEU B CB  1 
ATOM   2221 C CG  . LEU B 2 84  ? -8.216  5.224   10.440  1.00 30.27  ? 84  LEU B CG  1 
ATOM   2222 C CD1 . LEU B 2 84  ? -8.942  4.739   9.199   1.00 33.46  ? 84  LEU B CD1 1 
ATOM   2223 C CD2 . LEU B 2 84  ? -7.597  4.037   11.139  1.00 31.65  ? 84  LEU B CD2 1 
ATOM   2224 N N   . GLN B 2 85  ? -9.836  8.184   10.172  1.00 34.87  ? 85  GLN B N   1 
ATOM   2225 C CA  . GLN B 2 85  ? -10.755 8.924   11.008  1.00 34.21  ? 85  GLN B CA  1 
ATOM   2226 C C   . GLN B 2 85  ? -11.727 7.955   11.667  1.00 39.53  ? 85  GLN B C   1 
ATOM   2227 O O   . GLN B 2 85  ? -11.954 6.842   11.193  1.00 41.38  ? 85  GLN B O   1 
ATOM   2228 C CB  . GLN B 2 85  ? -11.395 10.034  10.186  1.00 36.69  ? 85  GLN B CB  1 
ATOM   2229 C CG  . GLN B 2 85  ? -10.615 11.341  10.293  1.00 40.50  ? 85  GLN B CG  1 
ATOM   2230 C CD  . GLN B 2 85  ? -10.734 12.202  9.064   1.00 43.33  ? 85  GLN B CD  1 
ATOM   2231 O OE1 . GLN B 2 85  ? -11.787 12.275  8.452   1.00 43.78  ? 85  GLN B OE1 1 
ATOM   2232 N NE2 . GLN B 2 85  ? -9.646  12.847  8.672   1.00 49.49  ? 85  GLN B NE2 1 
ATOM   2233 N N   . ALA B 2 86  ? -12.281 8.395   12.791  1.00 38.45  ? 86  ALA B N   1 
ATOM   2234 C CA  . ALA B 2 86  ? -13.031 7.526   13.679  1.00 39.83  ? 86  ALA B CA  1 
ATOM   2235 C C   . ALA B 2 86  ? -14.156 6.815   12.924  1.00 40.63  ? 86  ALA B C   1 
ATOM   2236 O O   . ALA B 2 86  ? -14.465 5.661   13.249  1.00 43.23  ? 86  ALA B O   1 
ATOM   2237 C CB  . ALA B 2 86  ? -13.546 8.350   14.849  1.00 39.75  ? 86  ALA B CB  1 
ATOM   2238 N N   . GLU B 2 87  ? -14.753 7.512   11.934  1.00 38.32  ? 87  GLU B N   1 
ATOM   2239 C CA  . GLU B 2 87  ? -15.885 7.019   11.149  1.00 42.90  ? 87  GLU B CA  1 
ATOM   2240 C C   . GLU B 2 87  ? -15.493 5.903   10.176  1.00 38.76  ? 87  GLU B C   1 
ATOM   2241 O O   . GLU B 2 87  ? -16.392 5.294   9.601   1.00 34.32  ? 87  GLU B O   1 
ATOM   2242 C CB  . GLU B 2 87  ? -16.502 8.056   10.199  1.00 45.77  ? 87  GLU B CB  1 
ATOM   2243 C CG  . GLU B 2 87  ? -16.579 9.451   10.746  1.00 54.71  ? 87  GLU B CG  1 
ATOM   2244 C CD  . GLU B 2 87  ? -15.346 10.296  10.492  1.00 57.16  ? 87  GLU B CD  1 
ATOM   2245 O OE1 . GLU B 2 87  ? -14.531 10.443  11.439  1.00 60.97  ? 87  GLU B OE1 1 
ATOM   2246 O OE2 . GLU B 2 87  ? -15.222 10.827  9.366   1.00 60.34  ? 87  GLU B OE2 1 
ATOM   2247 N N   . ASP B 2 88  ? -14.182 5.691   9.957   1.00 34.09  ? 88  ASP B N   1 
ATOM   2248 C CA  . ASP B 2 88  ? -13.683 4.725   8.984   1.00 33.82  ? 88  ASP B CA  1 
ATOM   2249 C C   . ASP B 2 88  ? -13.723 3.294   9.535   1.00 34.68  ? 88  ASP B C   1 
ATOM   2250 O O   . ASP B 2 88  ? -13.375 2.341   8.829   1.00 33.65  ? 88  ASP B O   1 
ATOM   2251 C CB  . ASP B 2 88  ? -12.271 5.121   8.546   1.00 31.17  ? 88  ASP B CB  1 
ATOM   2252 C CG  . ASP B 2 88  ? -12.229 6.478   7.856   1.00 32.40  ? 88  ASP B CG  1 
ATOM   2253 O OD1 . ASP B 2 88  ? -13.285 6.929   7.416   1.00 34.28  ? 88  ASP B OD1 1 
ATOM   2254 O OD2 . ASP B 2 88  ? -11.163 7.096   7.816   1.00 29.02  ? 88  ASP B OD2 1 
ATOM   2255 N N   . VAL B 2 89  ? -14.114 3.119   10.802  1.00 29.98  ? 89  VAL B N   1 
ATOM   2256 C CA  . VAL B 2 89  ? -14.178 1.782   11.364  1.00 30.83  ? 89  VAL B CA  1 
ATOM   2257 C C   . VAL B 2 89  ? -15.210 1.024   10.551  1.00 29.21  ? 89  VAL B C   1 
ATOM   2258 O O   . VAL B 2 89  ? -16.286 1.552   10.349  1.00 30.13  ? 89  VAL B O   1 
ATOM   2259 C CB  . VAL B 2 89  ? -14.543 1.791   12.861  1.00 33.66  ? 89  VAL B CB  1 
ATOM   2260 C CG1 . VAL B 2 89  ? -14.991 0.422   13.358  1.00 33.81  ? 89  VAL B CG1 1 
ATOM   2261 C CG2 . VAL B 2 89  ? -13.395 2.303   13.703  1.00 36.78  ? 89  VAL B CG2 1 
ATOM   2262 N N   . ALA B 2 90  ? -14.876 -0.181  10.082  1.00 27.37  ? 90  ALA B N   1 
ATOM   2263 C CA  . ALA B 2 90  ? -15.735 -0.899  9.151   1.00 27.55  ? 90  ALA B CA  1 
ATOM   2264 C C   . ALA B 2 90  ? -15.040 -2.171  8.690   1.00 26.21  ? 90  ALA B C   1 
ATOM   2265 O O   . ALA B 2 90  ? -13.907 -2.421  9.095   1.00 25.73  ? 90  ALA B O   1 
ATOM   2266 C CB  . ALA B 2 90  ? -16.065 -0.012  7.965   1.00 29.83  ? 90  ALA B CB  1 
ATOM   2267 N N   . VAL B 2 91  ? -15.752 -2.985  7.891   1.00 25.71  ? 91  VAL B N   1 
ATOM   2268 C CA  . VAL B 2 91  ? -15.143 -4.066  7.129   1.00 25.32  ? 91  VAL B CA  1 
ATOM   2269 C C   . VAL B 2 91  ? -15.014 -3.636  5.655   1.00 24.14  ? 91  VAL B C   1 
ATOM   2270 O O   . VAL B 2 91  ? -15.964 -3.131  5.043   1.00 20.74  ? 91  VAL B O   1 
ATOM   2271 C CB  . VAL B 2 91  ? -15.911 -5.385  7.311   1.00 25.00  ? 91  VAL B CB  1 
ATOM   2272 C CG1 . VAL B 2 91  ? -15.314 -6.524  6.504   1.00 26.27  ? 91  VAL B CG1 1 
ATOM   2273 C CG2 . VAL B 2 91  ? -16.015 -5.784  8.776   1.00 26.15  ? 91  VAL B CG2 1 
ATOM   2274 N N   . TYR B 2 92  ? -13.816 -3.870  5.086   1.00 22.93  ? 92  TYR B N   1 
ATOM   2275 C CA  . TYR B 2 92  ? -13.492 -3.519  3.709   1.00 21.63  ? 92  TYR B CA  1 
ATOM   2276 C C   . TYR B 2 92  ? -13.244 -4.770  2.877   1.00 22.92  ? 92  TYR B C   1 
ATOM   2277 O O   . TYR B 2 92  ? -12.499 -5.660  3.277   1.00 25.18  ? 92  TYR B O   1 
ATOM   2278 C CB  . TYR B 2 92  ? -12.262 -2.618  3.629   1.00 21.96  ? 92  TYR B CB  1 
ATOM   2279 C CG  . TYR B 2 92  ? -12.438 -1.302  4.334   1.00 22.86  ? 92  TYR B CG  1 
ATOM   2280 C CD1 . TYR B 2 92  ? -12.261 -1.196  5.711   1.00 23.80  ? 92  TYR B CD1 1 
ATOM   2281 C CD2 . TYR B 2 92  ? -12.857 -0.188  3.638   1.00 21.03  ? 92  TYR B CD2 1 
ATOM   2282 C CE1 . TYR B 2 92  ? -12.439 0.018   6.356   1.00 23.46  ? 92  TYR B CE1 1 
ATOM   2283 C CE2 . TYR B 2 92  ? -13.052 1.022   4.271   1.00 23.69  ? 92  TYR B CE2 1 
ATOM   2284 C CZ  . TYR B 2 92  ? -12.865 1.125   5.638   1.00 24.39  ? 92  TYR B CZ  1 
ATOM   2285 O OH  . TYR B 2 92  ? -13.052 2.356   6.238   1.00 26.71  ? 92  TYR B OH  1 
ATOM   2286 N N   . TYR B 2 93  ? -13.843 -4.766  1.687   1.00 23.01  ? 93  TYR B N   1 
ATOM   2287 C CA  . TYR B 2 93  ? -13.849 -5.876  0.755   1.00 21.86  ? 93  TYR B CA  1 
ATOM   2288 C C   . TYR B 2 93  ? -13.340 -5.409  -0.602  1.00 23.24  ? 93  TYR B C   1 
ATOM   2289 O O   . TYR B 2 93  ? -13.778 -4.366  -1.101  1.00 24.26  ? 93  TYR B O   1 
ATOM   2290 C CB  . TYR B 2 93  ? -15.278 -6.372  0.565   1.00 22.00  ? 93  TYR B CB  1 
ATOM   2291 C CG  . TYR B 2 93  ? -15.913 -6.977  1.793   1.00 20.53  ? 93  TYR B CG  1 
ATOM   2292 C CD1 . TYR B 2 93  ? -15.741 -8.320  2.083   1.00 21.87  ? 93  TYR B CD1 1 
ATOM   2293 C CD2 . TYR B 2 93  ? -16.708 -6.223  2.643   1.00 19.90  ? 93  TYR B CD2 1 
ATOM   2294 C CE1 . TYR B 2 93  ? -16.353 -8.917  3.178   1.00 23.13  ? 93  TYR B CE1 1 
ATOM   2295 C CE2 . TYR B 2 93  ? -17.349 -6.802  3.731   1.00 22.33  ? 93  TYR B CE2 1 
ATOM   2296 C CZ  . TYR B 2 93  ? -17.148 -8.148  4.017   1.00 25.25  ? 93  TYR B CZ  1 
ATOM   2297 O OH  . TYR B 2 93  ? -17.724 -8.753  5.104   1.00 27.45  ? 93  TYR B OH  1 
ATOM   2298 N N   . CYS B 2 94  ? -12.451 -6.206  -1.217  1.00 20.12  ? 94  CYS B N   1 
ATOM   2299 C CA  . CYS B 2 94  ? -12.176 -6.044  -2.632  1.00 19.69  ? 94  CYS B CA  1 
ATOM   2300 C C   . CYS B 2 94  ? -13.114 -6.936  -3.451  1.00 18.99  ? 94  CYS B C   1 
ATOM   2301 O O   . CYS B 2 94  ? -13.633 -7.909  -2.931  1.00 21.34  ? 94  CYS B O   1 
ATOM   2302 C CB  . CYS B 2 94  ? -10.718 -6.334  -2.968  1.00 21.12  ? 94  CYS B CB  1 
ATOM   2303 S SG  . CYS B 2 94  ? -10.163 -8.019  -2.590  1.00 23.04  ? 94  CYS B SG  1 
ATOM   2304 N N   . LEU B 2 95  ? -13.322 -6.576  -4.722  1.00 18.14  ? 95  LEU B N   1 
ATOM   2305 C CA  . LEU B 2 95  ? -14.184 -7.311  -5.642  1.00 20.04  ? 95  LEU B CA  1 
ATOM   2306 C C   . LEU B 2 95  ? -13.529 -7.311  -7.012  1.00 18.47  ? 95  LEU B C   1 
ATOM   2307 O O   . LEU B 2 95  ? -13.191 -6.247  -7.509  1.00 18.14  ? 95  LEU B O   1 
ATOM   2308 C CB  . LEU B 2 95  ? -15.570 -6.663  -5.769  1.00 18.23  ? 95  LEU B CB  1 
ATOM   2309 C CG  . LEU B 2 95  ? -16.445 -7.162  -6.933  1.00 18.99  ? 95  LEU B CG  1 
ATOM   2310 C CD1 . LEU B 2 95  ? -16.943 -8.575  -6.700  1.00 18.89  ? 95  LEU B CD1 1 
ATOM   2311 C CD2 . LEU B 2 95  ? -17.635 -6.226  -7.190  1.00 18.45  ? 95  LEU B CD2 1 
ATOM   2312 N N   . GLN B 2 96  ? -13.368 -8.489  -7.618  1.00 18.04  ? 96  GLN B N   1 
ATOM   2313 C CA  . GLN B 2 96  ? -13.064 -8.511  -9.047  1.00 18.29  ? 96  GLN B CA  1 
ATOM   2314 C C   . GLN B 2 96  ? -14.370 -8.753  -9.799  1.00 16.87  ? 96  GLN B C   1 
ATOM   2315 O O   . GLN B 2 96  ? -15.209 -9.543  -9.346  1.00 16.86  ? 96  GLN B O   1 
ATOM   2316 C CB  . GLN B 2 96  ? -12.005 -9.556  -9.421  1.00 17.26  ? 96  GLN B CB  1 
ATOM   2317 C CG  . GLN B 2 96  ? -12.505 -10.988 -9.398  1.00 17.99  ? 96  GLN B CG  1 
ATOM   2318 C CD  . GLN B 2 96  ? -13.229 -11.416 -10.648 1.00 18.11  ? 96  GLN B CD  1 
ATOM   2319 O OE1 . GLN B 2 96  ? -13.161 -10.761 -11.677 1.00 16.43  ? 96  GLN B OE1 1 
ATOM   2320 N NE2 . GLN B 2 96  ? -13.936 -12.535 -10.567 1.00 18.66  ? 96  GLN B NE2 1 
ATOM   2321 N N   . TYR B 2 97  ? -14.502 -8.092  -10.952 1.00 15.42  ? 97  TYR B N   1 
ATOM   2322 C CA  . TYR B 2 97  ? -15.708 -8.220  -11.755 1.00 18.06  ? 97  TYR B CA  1 
ATOM   2323 C C   . TYR B 2 97  ? -15.337 -8.403  -13.218 1.00 17.77  ? 97  TYR B C   1 
ATOM   2324 O O   . TYR B 2 97  ? -16.149 -8.140  -14.100 1.00 17.56  ? 97  TYR B O   1 
ATOM   2325 C CB  . TYR B 2 97  ? -16.623 -7.012  -11.554 1.00 15.72  ? 97  TYR B CB  1 
ATOM   2326 C CG  . TYR B 2 97  ? -15.951 -5.661  -11.697 1.00 15.66  ? 97  TYR B CG  1 
ATOM   2327 C CD1 . TYR B 2 97  ? -15.423 -5.005  -10.595 1.00 18.03  ? 97  TYR B CD1 1 
ATOM   2328 C CD2 . TYR B 2 97  ? -15.960 -4.977  -12.890 1.00 15.60  ? 97  TYR B CD2 1 
ATOM   2329 C CE1 . TYR B 2 97  ? -14.846 -3.742  -10.680 1.00 17.77  ? 97  TYR B CE1 1 
ATOM   2330 C CE2 . TYR B 2 97  ? -15.412 -3.714  -13.003 1.00 16.94  ? 97  TYR B CE2 1 
ATOM   2331 C CZ  . TYR B 2 97  ? -14.868 -3.089  -11.895 1.00 18.45  ? 97  TYR B CZ  1 
ATOM   2332 O OH  . TYR B 2 97  ? -14.358 -1.840  -12.031 1.00 18.75  ? 97  TYR B OH  1 
ATOM   2333 N N   . LEU B 2 98  ? -14.123 -8.892  -13.477 1.00 20.25  ? 98  LEU B N   1 
ATOM   2334 C CA  . LEU B 2 98  ? -13.739 -9.151  -14.851 1.00 20.37  ? 98  LEU B CA  1 
ATOM   2335 C C   . LEU B 2 98  ? -14.492 -10.384 -15.349 1.00 19.79  ? 98  LEU B C   1 
ATOM   2336 O O   . LEU B 2 98  ? -15.018 -10.350 -16.445 1.00 19.65  ? 98  LEU B O   1 
ATOM   2337 C CB  . LEU B 2 98  ? -12.225 -9.353  -14.976 1.00 22.57  ? 98  LEU B CB  1 
ATOM   2338 C CG  . LEU B 2 98  ? -11.740 -9.757  -16.383 1.00 22.00  ? 98  LEU B CG  1 
ATOM   2339 C CD1 . LEU B 2 98  ? -12.023 -8.662  -17.389 1.00 23.93  ? 98  LEU B CD1 1 
ATOM   2340 C CD2 . LEU B 2 98  ? -10.256 -10.082 -16.398 1.00 22.18  ? 98  LEU B CD2 1 
ATOM   2341 N N   . SER B 2 99  ? -14.490 -11.462 -14.556 1.00 20.45  ? 99  SER B N   1 
ATOM   2342 C CA  . SER B 2 99  ? -15.036 -12.751 -14.950 1.00 23.35  ? 99  SER B CA  1 
ATOM   2343 C C   . SER B 2 99  ? -15.926 -13.261 -13.813 1.00 19.76  ? 99  SER B C   1 
ATOM   2344 O O   . SER B 2 99  ? -15.435 -13.780 -12.827 1.00 18.53  ? 99  SER B O   1 
ATOM   2345 C CB  . SER B 2 99  ? -13.870 -13.695 -15.272 1.00 26.59  ? 99  SER B CB  1 
ATOM   2346 O OG  . SER B 2 99  ? -14.324 -14.941 -15.769 1.00 33.87  ? 99  SER B OG  1 
ATOM   2347 N N   . SER B 2 100 ? -17.241 -13.067 -13.914 1.00 19.74  ? 100 SER B N   1 
ATOM   2348 C CA  . SER B 2 100 ? -18.130 -13.185 -12.756 1.00 22.36  ? 100 SER B CA  1 
ATOM   2349 C C   . SER B 2 100 ? -17.680 -12.230 -11.643 1.00 20.93  ? 100 SER B C   1 
ATOM   2350 O O   . SER B 2 100 ? -16.882 -11.334 -11.876 1.00 23.42  ? 100 SER B O   1 
ATOM   2351 C CB  . SER B 2 100 ? -18.262 -14.637 -12.276 1.00 22.65  ? 100 SER B CB  1 
ATOM   2352 O OG  . SER B 2 100 ? -18.807 -15.442 -13.320 1.00 23.35  ? 100 SER B OG  1 
ATOM   2353 N N   . TRP B 2 101 ? -18.279 -12.345 -10.455 1.00 23.37  ? 101 TRP B N   1 
ATOM   2354 C CA  . TRP B 2 101 ? -17.843 -11.608 -9.281  1.00 23.54  ? 101 TRP B CA  1 
ATOM   2355 C C   . TRP B 2 101 ? -17.190 -12.577 -8.294  1.00 21.38  ? 101 TRP B C   1 
ATOM   2356 O O   . TRP B 2 101 ? -17.766 -13.621 -8.026  1.00 24.14  ? 101 TRP B O   1 
ATOM   2357 C CB  . TRP B 2 101 ? -19.004 -10.894 -8.577  1.00 23.06  ? 101 TRP B CB  1 
ATOM   2358 C CG  . TRP B 2 101 ? -19.583 -9.653  -9.197  1.00 21.36  ? 101 TRP B CG  1 
ATOM   2359 C CD1 . TRP B 2 101 ? -19.424 -9.172  -10.454 1.00 21.19  ? 101 TRP B CD1 1 
ATOM   2360 C CD2 . TRP B 2 101 ? -20.508 -8.760  -8.552  1.00 21.41  ? 101 TRP B CD2 1 
ATOM   2361 N NE1 . TRP B 2 101 ? -20.179 -8.042  -10.638 1.00 21.86  ? 101 TRP B NE1 1 
ATOM   2362 C CE2 . TRP B 2 101 ? -20.855 -7.762  -9.486  1.00 23.17  ? 101 TRP B CE2 1 
ATOM   2363 C CE3 . TRP B 2 101 ? -21.036 -8.682  -7.261  1.00 20.85  ? 101 TRP B CE3 1 
ATOM   2364 C CZ2 . TRP B 2 101 ? -21.708 -6.700  -9.169  1.00 24.33  ? 101 TRP B CZ2 1 
ATOM   2365 C CZ3 . TRP B 2 101 ? -21.921 -7.663  -6.959  1.00 22.60  ? 101 TRP B CZ3 1 
ATOM   2366 C CH2 . TRP B 2 101 ? -22.250 -6.683  -7.902  1.00 23.03  ? 101 TRP B CH2 1 
ATOM   2367 N N   . THR B 2 102 ? -16.051 -12.163 -7.714  1.00 20.10  ? 102 THR B N   1 
ATOM   2368 C CA  . THR B 2 102 ? -15.470 -12.763 -6.524  1.00 20.56  ? 102 THR B CA  1 
ATOM   2369 C C   . THR B 2 102 ? -15.066 -11.685 -5.528  1.00 20.61  ? 102 THR B C   1 
ATOM   2370 O O   . THR B 2 102 ? -14.264 -10.820 -5.867  1.00 21.25  ? 102 THR B O   1 
ATOM   2371 C CB  . THR B 2 102 ? -14.179 -13.532 -6.787  1.00 21.41  ? 102 THR B CB  1 
ATOM   2372 O OG1 . THR B 2 102 ? -14.306 -14.177 -8.039  1.00 22.66  ? 102 THR B OG1 1 
ATOM   2373 C CG2 . THR B 2 102 ? -13.907 -14.569 -5.724  1.00 24.19  ? 102 THR B CG2 1 
ATOM   2374 N N   . PHE B 2 103 ? -15.615 -11.775 -4.306  1.00 20.21  ? 103 PHE B N   1 
ATOM   2375 C CA  . PHE B 2 103 ? -15.280 -10.861 -3.223  1.00 21.40  ? 103 PHE B CA  1 
ATOM   2376 C C   . PHE B 2 103 ? -14.062 -11.420 -2.491  1.00 22.34  ? 103 PHE B C   1 
ATOM   2377 O O   . PHE B 2 103 ? -13.922 -12.633 -2.417  1.00 22.63  ? 103 PHE B O   1 
ATOM   2378 C CB  . PHE B 2 103 ? -16.473 -10.698 -2.280  1.00 20.16  ? 103 PHE B CB  1 
ATOM   2379 C CG  . PHE B 2 103 ? -17.544 -9.754  -2.767  1.00 18.01  ? 103 PHE B CG  1 
ATOM   2380 C CD1 . PHE B 2 103 ? -17.359 -8.392  -2.723  1.00 19.94  ? 103 PHE B CD1 1 
ATOM   2381 C CD2 . PHE B 2 103 ? -18.722 -10.228 -3.293  1.00 18.90  ? 103 PHE B CD2 1 
ATOM   2382 C CE1 . PHE B 2 103 ? -18.338 -7.520  -3.183  1.00 19.57  ? 103 PHE B CE1 1 
ATOM   2383 C CE2 . PHE B 2 103 ? -19.692 -9.368  -3.787  1.00 19.20  ? 103 PHE B CE2 1 
ATOM   2384 C CZ  . PHE B 2 103 ? -19.501 -8.011  -3.718  1.00 20.61  ? 103 PHE B CZ  1 
ATOM   2385 N N   . GLY B 2 104 ? -13.169 -10.549 -2.006  1.00 20.43  ? 104 GLY B N   1 
ATOM   2386 C CA  . GLY B 2 104 ? -12.228 -10.955 -0.977  1.00 21.20  ? 104 GLY B CA  1 
ATOM   2387 C C   . GLY B 2 104 ? -12.920 -11.300 0.340   1.00 21.89  ? 104 GLY B C   1 
ATOM   2388 O O   . GLY B 2 104 ? -14.089 -10.984 0.542   1.00 21.21  ? 104 GLY B O   1 
ATOM   2389 N N   . GLY B 2 105 ? -12.160 -11.915 1.256   1.00 23.72  ? 105 GLY B N   1 
ATOM   2390 C CA  . GLY B 2 105 ? -12.645 -12.329 2.564   1.00 23.70  ? 105 GLY B CA  1 
ATOM   2391 C C   . GLY B 2 105 ? -13.003 -11.160 3.489   1.00 27.32  ? 105 GLY B C   1 
ATOM   2392 O O   . GLY B 2 105 ? -13.630 -11.379 4.503   1.00 30.30  ? 105 GLY B O   1 
ATOM   2393 N N   . GLY B 2 106 ? -12.599 -9.926  3.165   1.00 27.26  ? 106 GLY B N   1 
ATOM   2394 C CA  . GLY B 2 106 ? -12.915 -8.776  3.995   1.00 26.62  ? 106 GLY B CA  1 
ATOM   2395 C C   . GLY B 2 106 ? -11.793 -8.482  4.995   1.00 28.09  ? 106 GLY B C   1 
ATOM   2396 O O   . GLY B 2 106 ? -11.100 -9.390  5.433   1.00 24.78  ? 106 GLY B O   1 
ATOM   2397 N N   . THR B 2 107 ? -11.614 -7.200  5.337   1.00 27.72  ? 107 THR B N   1 
ATOM   2398 C CA  . THR B 2 107 ? -10.608 -6.782  6.295   1.00 31.53  ? 107 THR B CA  1 
ATOM   2399 C C   . THR B 2 107 ? -11.257 -5.847  7.311   1.00 32.27  ? 107 THR B C   1 
ATOM   2400 O O   . THR B 2 107 ? -11.718 -4.770  6.938   1.00 26.81  ? 107 THR B O   1 
ATOM   2401 C CB  . THR B 2 107 ? -9.428  -6.066  5.630   1.00 29.46  ? 107 THR B CB  1 
ATOM   2402 O OG1 . THR B 2 107 ? -8.798  -6.967  4.728   1.00 31.26  ? 107 THR B OG1 1 
ATOM   2403 C CG2 . THR B 2 107 ? -8.415  -5.564  6.626   1.00 28.15  ? 107 THR B CG2 1 
ATOM   2404 N N   . LYS B 2 108 ? -11.273 -6.275  8.585   1.00 31.93  ? 108 LYS B N   1 
ATOM   2405 C CA  . LYS B 2 108 ? -11.856 -5.489  9.667   1.00 32.07  ? 108 LYS B CA  1 
ATOM   2406 C C   . LYS B 2 108 ? -10.846 -4.442  10.114  1.00 27.47  ? 108 LYS B C   1 
ATOM   2407 O O   . LYS B 2 108 ? -9.758  -4.769  10.564  1.00 27.67  ? 108 LYS B O   1 
ATOM   2408 C CB  . LYS B 2 108 ? -12.251 -6.411  10.823  1.00 36.28  ? 108 LYS B CB  1 
ATOM   2409 C CG  . LYS B 2 108 ? -13.124 -5.794  11.904  1.00 42.23  ? 108 LYS B CG  1 
ATOM   2410 C CD  . LYS B 2 108 ? -13.641 -6.867  12.873  1.00 49.91  ? 108 LYS B CD  1 
ATOM   2411 C CE  . LYS B 2 108 ? -14.148 -6.323  14.195  1.00 53.66  ? 108 LYS B CE  1 
ATOM   2412 N NZ  . LYS B 2 108 ? -15.449 -5.621  14.043  1.00 56.70  ? 108 LYS B NZ  1 
ATOM   2413 N N   . LEU B 2 109 ? -11.189 -3.171  9.956   1.00 28.20  ? 109 LEU B N   1 
ATOM   2414 C CA  . LEU B 2 109 ? -10.296 -2.104  10.373  1.00 30.75  ? 109 LEU B CA  1 
ATOM   2415 C C   . LEU B 2 109 ? -10.842 -1.480  11.656  1.00 33.86  ? 109 LEU B C   1 
ATOM   2416 O O   . LEU B 2 109 ? -12.023 -1.148  11.720  1.00 29.73  ? 109 LEU B O   1 
ATOM   2417 C CB  . LEU B 2 109 ? -10.186 -1.099  9.231   1.00 27.06  ? 109 LEU B CB  1 
ATOM   2418 C CG  . LEU B 2 109 ? -9.512  0.230   9.543   1.00 29.44  ? 109 LEU B CG  1 
ATOM   2419 C CD1 . LEU B 2 109 ? -8.057  0.043   9.945   1.00 30.67  ? 109 LEU B CD1 1 
ATOM   2420 C CD2 . LEU B 2 109 ? -9.613  1.144   8.333   1.00 27.48  ? 109 LEU B CD2 1 
ATOM   2421 N N   . GLU B 2 110 ? -9.968  -1.354  12.668  1.00 37.64  ? 110 GLU B N   1 
ATOM   2422 C CA  . GLU B 2 110 ? -10.302 -0.775  13.963  1.00 40.53  ? 110 GLU B CA  1 
ATOM   2423 C C   . GLU B 2 110 ? -9.364  0.398   14.216  1.00 38.66  ? 110 GLU B C   1 
ATOM   2424 O O   . GLU B 2 110 ? -8.358  0.553   13.526  1.00 35.66  ? 110 GLU B O   1 
ATOM   2425 C CB  . GLU B 2 110 ? -10.187 -1.825  15.075  1.00 48.73  ? 110 GLU B CB  1 
ATOM   2426 C CG  . GLU B 2 110 ? -11.125 -3.024  14.905  1.00 59.92  ? 110 GLU B CG  1 
ATOM   2427 C CD  . GLU B 2 110 ? -12.345 -3.104  15.818  1.00 69.60  ? 110 GLU B CD  1 
ATOM   2428 O OE1 . GLU B 2 110 ? -12.414 -4.069  16.622  1.00 75.53  ? 110 GLU B OE1 1 
ATOM   2429 O OE2 . GLU B 2 110 ? -13.238 -2.221  15.719  1.00 61.34  ? 110 GLU B OE2 1 
ATOM   2430 N N   . ILE B 2 111 ? -9.702  1.234   15.202  1.00 41.50  ? 111 ILE B N   1 
ATOM   2431 C CA  . ILE B 2 111 ? -8.822  2.329   15.576  1.00 46.82  ? 111 ILE B CA  1 
ATOM   2432 C C   . ILE B 2 111 ? -8.061  1.957   16.845  1.00 47.60  ? 111 ILE B C   1 
ATOM   2433 O O   . ILE B 2 111 ? -8.620  1.340   17.747  1.00 52.17  ? 111 ILE B O   1 
ATOM   2434 C CB  . ILE B 2 111 ? -9.591  3.657   15.699  1.00 53.07  ? 111 ILE B CB  1 
ATOM   2435 C CG1 . ILE B 2 111 ? -9.580  4.403   14.364  1.00 58.35  ? 111 ILE B CG1 1 
ATOM   2436 C CG2 . ILE B 2 111 ? -9.041  4.531   16.811  1.00 53.46  ? 111 ILE B CG2 1 
ATOM   2437 C CD1 . ILE B 2 111 ? -10.874 4.348   13.621  1.00 60.10  ? 111 ILE B CD1 1 
ATOM   2438 N N   . LYS B 2 112 ? -6.765  2.292   16.841  1.00 51.23  ? 112 LYS B N   1 
ATOM   2439 C CA  . LYS B 2 112 ? -5.876  2.179   17.984  1.00 59.89  ? 112 LYS B CA  1 
ATOM   2440 C C   . LYS B 2 112 ? -5.738  3.560   18.620  1.00 58.10  ? 112 LYS B C   1 
ATOM   2441 O O   . LYS B 2 112 ? -5.359  4.508   17.939  1.00 50.45  ? 112 LYS B O   1 
ATOM   2442 C CB  . LYS B 2 112 ? -4.506  1.638   17.553  1.00 64.54  ? 112 LYS B CB  1 
ATOM   2443 C CG  . LYS B 2 112 ? -3.505  1.438   18.687  1.00 70.84  ? 112 LYS B CG  1 
ATOM   2444 C CD  . LYS B 2 112 ? -2.354  0.509   18.344  1.00 75.19  ? 112 LYS B CD  1 
ATOM   2445 C CE  . LYS B 2 112 ? -1.237  1.190   17.579  1.00 76.76  ? 112 LYS B CE  1 
ATOM   2446 N NZ  . LYS B 2 112 ? -0.739  0.328   16.481  1.00 77.82  ? 112 LYS B NZ  1 
ATOM   2447 N N   . ARG B 2 113 ? -6.067  3.652   19.917  1.00 64.81  ? 113 ARG B N   1 
ATOM   2448 C CA  . ARG B 2 113 ? -6.077  4.909   20.657  1.00 65.49  ? 113 ARG B CA  1 
ATOM   2449 C C   . ARG B 2 113 ? -5.354  4.685   21.988  1.00 71.84  ? 113 ARG B C   1 
ATOM   2450 O O   . ARG B 2 113 ? -4.729  3.637   22.175  1.00 69.14  ? 113 ARG B O   1 
ATOM   2451 C CB  . ARG B 2 113 ? -7.516  5.431   20.792  1.00 60.44  ? 113 ARG B CB  1 
ATOM   2452 C CG  . ARG B 2 113 ? -8.540  4.374   21.182  1.00 64.03  ? 113 ARG B CG  1 
ATOM   2453 C CD  . ARG B 2 113 ? -9.607  4.949   22.089  1.00 63.21  ? 113 ARG B CD  1 
ATOM   2454 N NE  . ARG B 2 113 ? -8.963  5.448   23.297  1.00 65.37  ? 113 ARG B NE  1 
ATOM   2455 C CZ  . ARG B 2 113 ? -9.436  6.400   24.092  1.00 64.84  ? 113 ARG B CZ  1 
ATOM   2456 N NH1 . ARG B 2 113 ? -8.712  6.781   25.130  1.00 69.59  ? 113 ARG B NH1 1 
ATOM   2457 N NH2 . ARG B 2 113 ? -10.605 6.975   23.844  1.00 56.70  ? 113 ARG B NH2 1 
ATOM   2458 N N   . THR B 2 114 ? -5.402  5.690   22.885  1.00 78.52  ? 114 THR B N   1 
ATOM   2459 C CA  . THR B 2 114 ? -4.821  5.601   24.222  1.00 73.98  ? 114 THR B CA  1 
ATOM   2460 C C   . THR B 2 114 ? -5.672  4.710   25.125  1.00 75.79  ? 114 THR B C   1 
ATOM   2461 O O   . THR B 2 114 ? -6.887  4.613   24.950  1.00 76.32  ? 114 THR B O   1 
ATOM   2462 C CB  . THR B 2 114 ? -4.701  6.977   24.891  1.00 66.99  ? 114 THR B CB  1 
ATOM   2463 O OG1 . THR B 2 114 ? -5.948  7.657   24.736  1.00 66.31  ? 114 THR B OG1 1 
ATOM   2464 C CG2 . THR B 2 114 ? -3.581  7.810   24.312  1.00 66.50  ? 114 THR B CG2 1 
ATOM   2465 N N   . VAL B 2 115 ? -5.022  4.097   26.124  1.00 79.99  ? 115 VAL B N   1 
ATOM   2466 C CA  . VAL B 2 115 ? -5.713  3.260   27.095  1.00 74.84  ? 115 VAL B CA  1 
ATOM   2467 C C   . VAL B 2 115 ? -6.853  4.099   27.675  1.00 66.53  ? 115 VAL B C   1 
ATOM   2468 O O   . VAL B 2 115 ? -6.769  5.322   27.722  1.00 58.85  ? 115 VAL B O   1 
ATOM   2469 C CB  . VAL B 2 115 ? -4.774  2.718   28.200  1.00 76.60  ? 115 VAL B CB  1 
ATOM   2470 C CG1 . VAL B 2 115 ? -5.248  1.368   28.723  1.00 78.29  ? 115 VAL B CG1 1 
ATOM   2471 C CG2 . VAL B 2 115 ? -3.317  2.605   27.762  1.00 77.60  ? 115 VAL B CG2 1 
ATOM   2472 N N   . ALA B 2 116 ? -7.946  3.444   28.068  1.00 66.44  ? 116 ALA B N   1 
ATOM   2473 C CA  . ALA B 2 116 ? -9.100  4.148   28.598  1.00 65.02  ? 116 ALA B CA  1 
ATOM   2474 C C   . ALA B 2 116 ? -9.826  3.223   29.562  1.00 70.13  ? 116 ALA B C   1 
ATOM   2475 O O   . ALA B 2 116 ? -10.257 2.141   29.164  1.00 66.00  ? 116 ALA B O   1 
ATOM   2476 C CB  . ALA B 2 116 ? -10.015 4.593   27.488  1.00 63.33  ? 116 ALA B CB  1 
ATOM   2477 N N   . ALA B 2 117 ? -9.954  3.685   30.814  1.00 71.99  ? 117 ALA B N   1 
ATOM   2478 C CA  . ALA B 2 117 ? -10.527 2.899   31.891  1.00 65.03  ? 117 ALA B CA  1 
ATOM   2479 C C   . ALA B 2 117 ? -12.029 2.769   31.682  1.00 53.83  ? 117 ALA B C   1 
ATOM   2480 O O   . ALA B 2 117 ? -12.705 3.741   31.351  1.00 58.36  ? 117 ALA B O   1 
ATOM   2481 C CB  . ALA B 2 117 ? -10.220 3.537   33.226  1.00 71.88  ? 117 ALA B CB  1 
ATOM   2482 N N   . PRO B 2 118 ? -12.593 1.557   31.865  1.00 48.94  ? 118 PRO B N   1 
ATOM   2483 C CA  . PRO B 2 118 ? -14.043 1.377   31.831  1.00 50.74  ? 118 PRO B CA  1 
ATOM   2484 C C   . PRO B 2 118 ? -14.750 2.014   33.023  1.00 55.04  ? 118 PRO B C   1 
ATOM   2485 O O   . PRO B 2 118 ? -14.218 2.011   34.126  1.00 56.94  ? 118 PRO B O   1 
ATOM   2486 C CB  . PRO B 2 118 ? -14.226 -0.149  31.887  1.00 53.37  ? 118 PRO B CB  1 
ATOM   2487 C CG  . PRO B 2 118 ? -12.951 -0.665  32.529  1.00 53.80  ? 118 PRO B CG  1 
ATOM   2488 C CD  . PRO B 2 118 ? -11.865 0.299   32.096  1.00 49.92  ? 118 PRO B CD  1 
ATOM   2489 N N   . SER B 2 119 ? -15.949 2.553   32.785  1.00 59.48  ? 119 SER B N   1 
ATOM   2490 C CA  . SER B 2 119 ? -16.838 2.972   33.855  1.00 59.67  ? 119 SER B CA  1 
ATOM   2491 C C   . SER B 2 119 ? -17.769 1.814   34.209  1.00 59.06  ? 119 SER B C   1 
ATOM   2492 O O   . SER B 2 119 ? -18.661 1.457   33.429  1.00 50.97  ? 119 SER B O   1 
ATOM   2493 C CB  . SER B 2 119 ? -17.614 4.199   33.465  1.00 61.25  ? 119 SER B CB  1 
ATOM   2494 O OG  . SER B 2 119 ? -16.750 5.320   33.371  1.00 60.08  ? 119 SER B OG  1 
ATOM   2495 N N   . VAL B 2 120 ? -17.553 1.233   35.394  1.00 53.72  ? 120 VAL B N   1 
ATOM   2496 C CA  . VAL B 2 120 ? -18.322 0.071   35.809  1.00 54.27  ? 120 VAL B CA  1 
ATOM   2497 C C   . VAL B 2 120 ? -19.572 0.533   36.551  1.00 56.16  ? 120 VAL B C   1 
ATOM   2498 O O   . VAL B 2 120 ? -19.520 1.426   37.393  1.00 62.68  ? 120 VAL B O   1 
ATOM   2499 C CB  . VAL B 2 120 ? -17.496 -0.907  36.660  1.00 54.50  ? 120 VAL B CB  1 
ATOM   2500 C CG1 . VAL B 2 120 ? -18.196 -2.256  36.778  1.00 56.60  ? 120 VAL B CG1 1 
ATOM   2501 C CG2 . VAL B 2 120 ? -16.085 -1.086  36.117  1.00 57.62  ? 120 VAL B CG2 1 
ATOM   2502 N N   . PHE B 2 121 ? -20.698 -0.093  36.206  1.00 57.61  ? 121 PHE B N   1 
ATOM   2503 C CA  . PHE B 2 121 ? -21.967 0.133   36.870  1.00 61.70  ? 121 PHE B CA  1 
ATOM   2504 C C   . PHE B 2 121 ? -22.631 -1.226  37.059  1.00 66.32  ? 121 PHE B C   1 
ATOM   2505 O O   . PHE B 2 121 ? -22.402 -2.130  36.251  1.00 62.33  ? 121 PHE B O   1 
ATOM   2506 C CB  . PHE B 2 121 ? -22.827 1.089   36.041  1.00 61.68  ? 121 PHE B CB  1 
ATOM   2507 C CG  . PHE B 2 121 ? -22.178 2.426   35.794  1.00 69.03  ? 121 PHE B CG  1 
ATOM   2508 C CD1 . PHE B 2 121 ? -22.135 3.391   36.788  1.00 71.15  ? 121 PHE B CD1 1 
ATOM   2509 C CD2 . PHE B 2 121 ? -21.568 2.702   34.581  1.00 73.19  ? 121 PHE B CD2 1 
ATOM   2510 C CE1 . PHE B 2 121 ? -21.533 4.619   36.559  1.00 72.61  ? 121 PHE B CE1 1 
ATOM   2511 C CE2 . PHE B 2 121 ? -20.957 3.926   34.358  1.00 75.61  ? 121 PHE B CE2 1 
ATOM   2512 C CZ  . PHE B 2 121 ? -20.943 4.883   35.346  1.00 75.41  ? 121 PHE B CZ  1 
ATOM   2513 N N   . ILE B 2 122 ? -23.429 -1.358  38.132  1.00 62.17  ? 122 ILE B N   1 
ATOM   2514 C CA  . ILE B 2 122 ? -24.189 -2.572  38.382  1.00 62.14  ? 122 ILE B CA  1 
ATOM   2515 C C   . ILE B 2 122 ? -25.659 -2.210  38.567  1.00 59.00  ? 122 ILE B C   1 
ATOM   2516 O O   . ILE B 2 122 ? -25.993 -1.117  39.017  1.00 67.21  ? 122 ILE B O   1 
ATOM   2517 C CB  . ILE B 2 122 ? -23.627 -3.360  39.582  1.00 66.85  ? 122 ILE B CB  1 
ATOM   2518 C CG1 . ILE B 2 122 ? -24.075 -4.826  39.547  1.00 68.77  ? 122 ILE B CG1 1 
ATOM   2519 C CG2 . ILE B 2 122 ? -23.994 -2.682  40.897  1.00 67.67  ? 122 ILE B CG2 1 
ATOM   2520 C CD1 . ILE B 2 122 ? -23.294 -5.741  40.466  1.00 67.20  ? 122 ILE B CD1 1 
ATOM   2521 N N   . PHE B 2 123 ? -26.522 -3.153  38.195  1.00 54.65  ? 123 PHE B N   1 
ATOM   2522 C CA  . PHE B 2 123 ? -27.951 -2.933  38.125  1.00 62.61  ? 123 PHE B CA  1 
ATOM   2523 C C   . PHE B 2 123 ? -28.640 -4.194  38.629  1.00 70.04  ? 123 PHE B C   1 
ATOM   2524 O O   . PHE B 2 123 ? -28.533 -5.249  38.004  1.00 68.73  ? 123 PHE B O   1 
ATOM   2525 C CB  . PHE B 2 123 ? -28.404 -2.625  36.694  1.00 68.96  ? 123 PHE B CB  1 
ATOM   2526 C CG  . PHE B 2 123 ? -27.756 -1.423  36.052  1.00 73.90  ? 123 PHE B CG  1 
ATOM   2527 C CD1 . PHE B 2 123 ? -26.468 -1.489  35.542  1.00 74.11  ? 123 PHE B CD1 1 
ATOM   2528 C CD2 . PHE B 2 123 ? -28.435 -0.220  35.959  1.00 75.77  ? 123 PHE B CD2 1 
ATOM   2529 C CE1 . PHE B 2 123 ? -25.872 -0.382  34.960  1.00 75.15  ? 123 PHE B CE1 1 
ATOM   2530 C CE2 . PHE B 2 123 ? -27.841 0.885   35.370  1.00 77.76  ? 123 PHE B CE2 1 
ATOM   2531 C CZ  . PHE B 2 123 ? -26.560 0.803   34.873  1.00 76.93  ? 123 PHE B CZ  1 
ATOM   2532 N N   . PRO B 2 124 ? -29.340 -4.135  39.785  1.00 69.53  ? 124 PRO B N   1 
ATOM   2533 C CA  . PRO B 2 124 ? -30.061 -5.298  40.304  1.00 65.37  ? 124 PRO B CA  1 
ATOM   2534 C C   . PRO B 2 124 ? -31.260 -5.620  39.424  1.00 57.62  ? 124 PRO B C   1 
ATOM   2535 O O   . PRO B 2 124 ? -31.729 -4.738  38.710  1.00 55.80  ? 124 PRO B O   1 
ATOM   2536 C CB  . PRO B 2 124 ? -30.530 -4.823  41.687  1.00 68.57  ? 124 PRO B CB  1 
ATOM   2537 C CG  . PRO B 2 124 ? -30.674 -3.322  41.521  1.00 69.00  ? 124 PRO B CG  1 
ATOM   2538 C CD  . PRO B 2 124 ? -29.505 -2.943  40.634  1.00 69.51  ? 124 PRO B CD  1 
ATOM   2539 N N   . PRO B 2 125 ? -31.804 -6.862  39.467  1.00 54.11  ? 125 PRO B N   1 
ATOM   2540 C CA  . PRO B 2 125 ? -33.021 -7.203  38.732  1.00 57.22  ? 125 PRO B CA  1 
ATOM   2541 C C   . PRO B 2 125 ? -34.190 -6.296  39.104  1.00 65.76  ? 125 PRO B C   1 
ATOM   2542 O O   . PRO B 2 125 ? -34.225 -5.737  40.196  1.00 72.42  ? 125 PRO B O   1 
ATOM   2543 C CB  . PRO B 2 125 ? -33.360 -8.653  39.128  1.00 55.09  ? 125 PRO B CB  1 
ATOM   2544 C CG  . PRO B 2 125 ? -32.475 -8.955  40.322  1.00 52.58  ? 125 PRO B CG  1 
ATOM   2545 C CD  . PRO B 2 125 ? -31.292 -8.006  40.232  1.00 53.65  ? 125 PRO B CD  1 
ATOM   2546 N N   . SER B 2 126 ? -35.139 -6.165  38.173  1.00 72.76  ? 126 SER B N   1 
ATOM   2547 C CA  . SER B 2 126 ? -36.350 -5.399  38.394  1.00 70.49  ? 126 SER B CA  1 
ATOM   2548 C C   . SER B 2 126 ? -37.334 -6.242  39.193  1.00 76.83  ? 126 SER B C   1 
ATOM   2549 O O   . SER B 2 126 ? -37.243 -7.474  39.194  1.00 74.94  ? 126 SER B O   1 
ATOM   2550 C CB  . SER B 2 126 ? -36.966 -4.998  37.093  1.00 69.45  ? 126 SER B CB  1 
ATOM   2551 O OG  . SER B 2 126 ? -37.596 -6.121  36.498  1.00 68.43  ? 126 SER B OG  1 
ATOM   2552 N N   . ASP B 2 127 ? -38.292 -5.557  39.827  1.00 71.36  ? 127 ASP B N   1 
ATOM   2553 C CA  . ASP B 2 127 ? -39.349 -6.230  40.558  1.00 76.27  ? 127 ASP B CA  1 
ATOM   2554 C C   . ASP B 2 127 ? -40.265 -6.918  39.555  1.00 69.59  ? 127 ASP B C   1 
ATOM   2555 O O   . ASP B 2 127 ? -40.668 -8.052  39.787  1.00 67.08  ? 127 ASP B O   1 
ATOM   2556 C CB  . ASP B 2 127 ? -40.096 -5.260  41.477  1.00 86.88  ? 127 ASP B CB  1 
ATOM   2557 C CG  . ASP B 2 127 ? -39.245 -4.758  42.635  1.00 94.09  ? 127 ASP B CG  1 
ATOM   2558 O OD1 . ASP B 2 127 ? -38.766 -5.605  43.422  1.00 95.74  ? 127 ASP B OD1 1 
ATOM   2559 O OD2 . ASP B 2 127 ? -39.059 -3.525  42.739  1.00 95.99  ? 127 ASP B OD2 1 
ATOM   2560 N N   . GLU B 2 128 ? -40.521 -6.239  38.423  1.00 69.74  ? 128 GLU B N   1 
ATOM   2561 C CA  . GLU B 2 128 ? -41.430 -6.717  37.388  1.00 61.80  ? 128 GLU B CA  1 
ATOM   2562 C C   . GLU B 2 128 ? -40.992 -8.083  36.865  1.00 60.00  ? 128 GLU B C   1 
ATOM   2563 O O   . GLU B 2 128 ? -41.828 -8.898  36.478  1.00 60.13  ? 128 GLU B O   1 
ATOM   2564 C CB  . GLU B 2 128 ? -41.458 -5.788  36.171  1.00 66.63  ? 128 GLU B CB  1 
ATOM   2565 C CG  . GLU B 2 128 ? -41.483 -4.300  36.475  1.00 65.84  ? 128 GLU B CG  1 
ATOM   2566 C CD  . GLU B 2 128 ? -41.769 -3.428  35.260  1.00 66.07  ? 128 GLU B CD  1 
ATOM   2567 O OE1 . GLU B 2 128 ? -42.044 -3.985  34.167  1.00 65.71  ? 128 GLU B OE1 1 
ATOM   2568 O OE2 . GLU B 2 128 ? -41.717 -2.195  35.405  1.00 60.60  ? 128 GLU B OE2 1 
ATOM   2569 N N   . GLN B 2 129 ? -39.668 -8.278  36.786  1.00 65.36  ? 129 GLN B N   1 
ATOM   2570 C CA  . GLN B 2 129 ? -39.075 -9.499  36.260  1.00 67.67  ? 129 GLN B CA  1 
ATOM   2571 C C   . GLN B 2 129 ? -39.265 -10.619 37.275  1.00 71.26  ? 129 GLN B C   1 
ATOM   2572 O O   . GLN B 2 129 ? -39.793 -11.679 36.950  1.00 70.96  ? 129 GLN B O   1 
ATOM   2573 C CB  . GLN B 2 129 ? -37.586 -9.281  35.965  1.00 63.89  ? 129 GLN B CB  1 
ATOM   2574 C CG  . GLN B 2 129 ? -36.910 -10.471 35.292  1.00 59.97  ? 129 GLN B CG  1 
ATOM   2575 C CD  . GLN B 2 129 ? -35.430 -10.265 35.065  1.00 53.12  ? 129 GLN B CD  1 
ATOM   2576 O OE1 . GLN B 2 129 ? -34.883 -9.188  35.294  1.00 51.32  ? 129 GLN B OE1 1 
ATOM   2577 N NE2 . GLN B 2 129 ? -34.772 -11.311 34.596  1.00 49.82  ? 129 GLN B NE2 1 
ATOM   2578 N N   . LEU B 2 130 ? -38.849 -10.337 38.515  1.00 80.62  ? 130 LEU B N   1 
ATOM   2579 C CA  . LEU B 2 130 ? -38.863 -11.299 39.606  1.00 82.76  ? 130 LEU B CA  1 
ATOM   2580 C C   . LEU B 2 130 ? -40.252 -11.901 39.820  1.00 86.54  ? 130 LEU B C   1 
ATOM   2581 O O   . LEU B 2 130 ? -40.358 -12.991 40.376  1.00 86.91  ? 130 LEU B O   1 
ATOM   2582 C CB  . LEU B 2 130 ? -38.372 -10.587 40.867  1.00 80.30  ? 130 LEU B CB  1 
ATOM   2583 C CG  . LEU B 2 130 ? -36.877 -10.285 40.890  1.00 82.66  ? 130 LEU B CG  1 
ATOM   2584 C CD1 . LEU B 2 130 ? -36.534 -9.288  41.991  1.00 83.44  ? 130 LEU B CD1 1 
ATOM   2585 C CD2 . LEU B 2 130 ? -36.082 -11.571 41.062  1.00 81.14  ? 130 LEU B CD2 1 
ATOM   2586 N N   . LYS B 2 131 ? -41.309 -11.204 39.378  1.00 88.99  ? 131 LYS B N   1 
ATOM   2587 C CA  . LYS B 2 131 ? -42.664 -11.724 39.498  1.00 91.68  ? 131 LYS B CA  1 
ATOM   2588 C C   . LYS B 2 131 ? -42.827 -12.978 38.639  1.00 89.51  ? 131 LYS B C   1 
ATOM   2589 O O   . LYS B 2 131 ? -43.424 -13.955 39.081  1.00 84.81  ? 131 LYS B O   1 
ATOM   2590 C CB  . LYS B 2 131 ? -43.709 -10.666 39.117  1.00 91.06  ? 131 LYS B CB  1 
ATOM   2591 C CG  . LYS B 2 131 ? -45.141 -11.034 39.490  1.00 89.18  ? 131 LYS B CG  1 
ATOM   2592 C CD  . LYS B 2 131 ? -45.382 -11.091 40.994  1.00 88.02  ? 131 LYS B CD  1 
ATOM   2593 C CE  . LYS B 2 131 ? -46.252 -12.251 41.431  1.00 85.05  ? 131 LYS B CE  1 
ATOM   2594 N NZ  . LYS B 2 131 ? -47.597 -12.192 40.816  1.00 86.10  ? 131 LYS B NZ  1 
ATOM   2595 N N   . SER B 2 132 ? -42.306 -12.937 37.408  1.00 91.15  ? 132 SER B N   1 
ATOM   2596 C CA  . SER B 2 132 ? -42.294 -14.098 36.529  1.00 83.95  ? 132 SER B CA  1 
ATOM   2597 C C   . SER B 2 132 ? -41.194 -15.071 36.958  1.00 79.86  ? 132 SER B C   1 
ATOM   2598 O O   . SER B 2 132 ? -41.134 -16.211 36.492  1.00 69.55  ? 132 SER B O   1 
ATOM   2599 C CB  . SER B 2 132 ? -42.145 -13.664 35.092  1.00 86.41  ? 132 SER B CB  1 
ATOM   2600 O OG  . SER B 2 132 ? -41.220 -12.591 34.983  1.00 89.10  ? 132 SER B OG  1 
ATOM   2601 N N   . GLY B 2 133 ? -40.297 -14.589 37.826  1.00 76.19  ? 133 GLY B N   1 
ATOM   2602 C CA  . GLY B 2 133 ? -39.437 -15.458 38.607  1.00 75.34  ? 133 GLY B CA  1 
ATOM   2603 C C   . GLY B 2 133 ? -38.132 -15.804 37.894  1.00 73.06  ? 133 GLY B C   1 
ATOM   2604 O O   . GLY B 2 133 ? -37.797 -16.981 37.788  1.00 70.08  ? 133 GLY B O   1 
ATOM   2605 N N   . THR B 2 134 ? -37.399 -14.782 37.425  1.00 65.77  ? 134 THR B N   1 
ATOM   2606 C CA  . THR B 2 134 ? -36.000 -14.955 37.054  1.00 66.85  ? 134 THR B CA  1 
ATOM   2607 C C   . THR B 2 134 ? -35.234 -13.679 37.392  1.00 62.28  ? 134 THR B C   1 
ATOM   2608 O O   . THR B 2 134 ? -35.799 -12.590 37.442  1.00 61.46  ? 134 THR B O   1 
ATOM   2609 C CB  . THR B 2 134 ? -35.823 -15.352 35.580  1.00 73.37  ? 134 THR B CB  1 
ATOM   2610 O OG1 . THR B 2 134 ? -36.952 -16.110 35.138  1.00 69.32  ? 134 THR B OG1 1 
ATOM   2611 C CG2 . THR B 2 134 ? -34.571 -16.169 35.337  1.00 73.39  ? 134 THR B CG2 1 
ATOM   2612 N N   . ALA B 2 135 ? -33.932 -13.833 37.623  1.00 62.26  ? 135 ALA B N   1 
ATOM   2613 C CA  . ALA B 2 135 ? -33.092 -12.739 38.069  1.00 62.74  ? 135 ALA B CA  1 
ATOM   2614 C C   . ALA B 2 135 ? -32.002 -12.474 37.041  1.00 57.49  ? 135 ALA B C   1 
ATOM   2615 O O   . ALA B 2 135 ? -31.197 -13.352 36.751  1.00 54.51  ? 135 ALA B O   1 
ATOM   2616 C CB  . ALA B 2 135 ? -32.491 -13.092 39.403  1.00 69.75  ? 135 ALA B CB  1 
ATOM   2617 N N   . SER B 2 136 ? -31.987 -11.248 36.512  1.00 55.58  ? 136 SER B N   1 
ATOM   2618 C CA  . SER B 2 136 ? -30.955 -10.823 35.586  1.00 52.69  ? 136 SER B CA  1 
ATOM   2619 C C   . SER B 2 136 ? -30.197 -9.662  36.206  1.00 49.33  ? 136 SER B C   1 
ATOM   2620 O O   . SER B 2 136 ? -30.702 -8.549  36.285  1.00 56.85  ? 136 SER B O   1 
ATOM   2621 C CB  . SER B 2 136 ? -31.523 -10.438 34.240  1.00 52.18  ? 136 SER B CB  1 
ATOM   2622 O OG  . SER B 2 136 ? -32.116 -11.556 33.595  1.00 51.04  ? 136 SER B OG  1 
ATOM   2623 N N   . VAL B 2 137 ? -28.984 -9.947  36.654  1.00 47.76  ? 137 VAL B N   1 
ATOM   2624 C CA  . VAL B 2 137 ? -28.123 -8.923  37.210  1.00 50.89  ? 137 VAL B CA  1 
ATOM   2625 C C   . VAL B 2 137 ? -27.214 -8.461  36.078  1.00 52.42  ? 137 VAL B C   1 
ATOM   2626 O O   . VAL B 2 137 ? -26.558 -9.290  35.447  1.00 54.88  ? 137 VAL B O   1 
ATOM   2627 C CB  . VAL B 2 137 ? -27.295 -9.462  38.394  1.00 47.70  ? 137 VAL B CB  1 
ATOM   2628 C CG1 . VAL B 2 137 ? -26.615 -8.336  39.148  1.00 49.74  ? 137 VAL B CG1 1 
ATOM   2629 C CG2 . VAL B 2 137 ? -28.123 -10.325 39.337  1.00 48.50  ? 137 VAL B CG2 1 
ATOM   2630 N N   . VAL B 2 138 ? -27.174 -7.149  35.838  1.00 49.51  ? 138 VAL B N   1 
ATOM   2631 C CA  . VAL B 2 138 ? -26.476 -6.607  34.686  1.00 48.66  ? 138 VAL B CA  1 
ATOM   2632 C C   . VAL B 2 138 ? -25.300 -5.765  35.159  1.00 44.94  ? 138 VAL B C   1 
ATOM   2633 O O   . VAL B 2 138 ? -25.500 -4.754  35.814  1.00 45.20  ? 138 VAL B O   1 
ATOM   2634 C CB  . VAL B 2 138 ? -27.424 -5.789  33.794  1.00 47.50  ? 138 VAL B CB  1 
ATOM   2635 C CG1 . VAL B 2 138 ? -26.668 -5.070  32.682  1.00 51.01  ? 138 VAL B CG1 1 
ATOM   2636 C CG2 . VAL B 2 138 ? -28.539 -6.648  33.228  1.00 42.56  ? 138 VAL B CG2 1 
ATOM   2637 N N   . CYS B 2 139 ? -24.085 -6.199  34.819  1.00 44.61  ? 139 CYS B N   1 
ATOM   2638 C CA  . CYS B 2 139 ? -22.886 -5.379  34.946  1.00 51.56  ? 139 CYS B CA  1 
ATOM   2639 C C   . CYS B 2 139 ? -22.617 -4.706  33.596  1.00 52.36  ? 139 CYS B C   1 
ATOM   2640 O O   . CYS B 2 139 ? -22.822 -5.312  32.544  1.00 52.49  ? 139 CYS B O   1 
ATOM   2641 C CB  . CYS B 2 139 ? -21.706 -6.233  35.416  1.00 57.50  ? 139 CYS B CB  1 
ATOM   2642 S SG  . CYS B 2 139 ? -20.215 -5.321  35.907  1.00 66.89  ? 139 CYS B SG  1 
ATOM   2643 N N   . LEU B 2 140 ? -22.188 -3.439  33.645  1.00 52.18  ? 140 LEU B N   1 
ATOM   2644 C CA  . LEU B 2 140 ? -21.896 -2.642  32.467  1.00 51.28  ? 140 LEU B CA  1 
ATOM   2645 C C   . LEU B 2 140 ? -20.502 -2.046  32.600  1.00 53.00  ? 140 LEU B C   1 
ATOM   2646 O O   . LEU B 2 140 ? -20.206 -1.396  33.593  1.00 59.34  ? 140 LEU B O   1 
ATOM   2647 C CB  . LEU B 2 140 ? -22.934 -1.524  32.324  1.00 53.27  ? 140 LEU B CB  1 
ATOM   2648 C CG  . LEU B 2 140 ? -22.477 -0.312  31.507  1.00 55.40  ? 140 LEU B CG  1 
ATOM   2649 C CD1 . LEU B 2 140 ? -22.208 -0.697  30.063  1.00 57.30  ? 140 LEU B CD1 1 
ATOM   2650 C CD2 . LEU B 2 140 ? -23.513 0.799   31.547  1.00 59.00  ? 140 LEU B CD2 1 
ATOM   2651 N N   . LEU B 2 141 ? -19.648 -2.297  31.602  1.00 52.74  ? 141 LEU B N   1 
ATOM   2652 C CA  . LEU B 2 141 ? -18.406 -1.561  31.417  1.00 53.28  ? 141 LEU B CA  1 
ATOM   2653 C C   . LEU B 2 141 ? -18.650 -0.554  30.298  1.00 58.43  ? 141 LEU B C   1 
ATOM   2654 O O   . LEU B 2 141 ? -19.256 -0.904  29.286  1.00 66.60  ? 141 LEU B O   1 
ATOM   2655 C CB  . LEU B 2 141 ? -17.280 -2.523  31.028  1.00 51.37  ? 141 LEU B CB  1 
ATOM   2656 C CG  . LEU B 2 141 ? -16.709 -3.408  32.129  1.00 50.04  ? 141 LEU B CG  1 
ATOM   2657 C CD1 . LEU B 2 141 ? -17.764 -4.330  32.732  1.00 51.25  ? 141 LEU B CD1 1 
ATOM   2658 C CD2 . LEU B 2 141 ? -15.557 -4.224  31.578  1.00 52.73  ? 141 LEU B CD2 1 
ATOM   2659 N N   . ASN B 2 142 ? -18.190 0.687   30.475  1.00 57.84  ? 142 ASN B N   1 
ATOM   2660 C CA  . ASN B 2 142 ? -18.571 1.737   29.551  1.00 59.65  ? 142 ASN B CA  1 
ATOM   2661 C C   . ASN B 2 142 ? -17.326 2.513   29.133  1.00 60.90  ? 142 ASN B C   1 
ATOM   2662 O O   . ASN B 2 142 ? -16.537 2.884   29.993  1.00 56.98  ? 142 ASN B O   1 
ATOM   2663 C CB  . ASN B 2 142 ? -19.681 2.590   30.163  1.00 63.81  ? 142 ASN B CB  1 
ATOM   2664 C CG  . ASN B 2 142 ? -20.350 3.495   29.154  1.00 65.61  ? 142 ASN B CG  1 
ATOM   2665 O OD1 . ASN B 2 142 ? -21.355 3.120   28.557  1.00 61.76  ? 142 ASN B OD1 1 
ATOM   2666 N ND2 . ASN B 2 142 ? -19.788 4.673   28.946  1.00 66.53  ? 142 ASN B ND2 1 
ATOM   2667 N N   . ASN B 2 143 ? -17.149 2.659   27.803  1.00 60.43  ? 143 ASN B N   1 
ATOM   2668 C CA  . ASN B 2 143 ? -16.167 3.522   27.151  1.00 54.22  ? 143 ASN B CA  1 
ATOM   2669 C C   . ASN B 2 143 ? -14.731 3.176   27.534  1.00 53.81  ? 143 ASN B C   1 
ATOM   2670 O O   . ASN B 2 143 ? -13.960 4.049   27.928  1.00 57.37  ? 143 ASN B O   1 
ATOM   2671 C CB  . ASN B 2 143 ? -16.440 5.007   27.390  1.00 54.89  ? 143 ASN B CB  1 
ATOM   2672 C CG  . ASN B 2 143 ? -17.724 5.474   26.741  1.00 60.21  ? 143 ASN B CG  1 
ATOM   2673 O OD1 . ASN B 2 143 ? -18.480 4.683   26.175  1.00 50.12  ? 143 ASN B OD1 1 
ATOM   2674 N ND2 . ASN B 2 143 ? -17.983 6.767   26.827  1.00 72.03  ? 143 ASN B ND2 1 
ATOM   2675 N N   . PHE B 2 144 ? -14.334 1.926   27.292  1.00 55.59  ? 144 PHE B N   1 
ATOM   2676 C CA  . PHE B 2 144 ? -12.958 1.529   27.548  1.00 58.58  ? 144 PHE B CA  1 
ATOM   2677 C C   . PHE B 2 144 ? -12.209 1.278   26.240  1.00 53.64  ? 144 PHE B C   1 
ATOM   2678 O O   . PHE B 2 144 ? -12.806 1.141   25.182  1.00 59.34  ? 144 PHE B O   1 
ATOM   2679 C CB  . PHE B 2 144 ? -12.912 0.278   28.425  1.00 58.82  ? 144 PHE B CB  1 
ATOM   2680 C CG  . PHE B 2 144 ? -13.765 -0.877  27.960  1.00 56.50  ? 144 PHE B CG  1 
ATOM   2681 C CD1 . PHE B 2 144 ? -15.139 -0.884  28.165  1.00 55.97  ? 144 PHE B CD1 1 
ATOM   2682 C CD2 . PHE B 2 144 ? -13.189 -1.968  27.330  1.00 53.04  ? 144 PHE B CD2 1 
ATOM   2683 C CE1 . PHE B 2 144 ? -15.914 -1.960  27.761  1.00 53.16  ? 144 PHE B CE1 1 
ATOM   2684 C CE2 . PHE B 2 144 ? -13.967 -3.041  26.925  1.00 52.69  ? 144 PHE B CE2 1 
ATOM   2685 C CZ  . PHE B 2 144 ? -15.325 -3.037  27.143  1.00 51.29  ? 144 PHE B CZ  1 
ATOM   2686 N N   . TYR B 2 145 ? -10.884 1.234   26.334  1.00 50.59  ? 145 TYR B N   1 
ATOM   2687 C CA  . TYR B 2 145 ? -10.054 0.695   25.275  1.00 54.36  ? 145 TYR B CA  1 
ATOM   2688 C C   . TYR B 2 145 ? -8.768  0.193   25.909  1.00 55.10  ? 145 TYR B C   1 
ATOM   2689 O O   . TYR B 2 145 ? -8.290  0.822   26.851  1.00 64.65  ? 145 TYR B O   1 
ATOM   2690 C CB  . TYR B 2 145 ? -9.749  1.751   24.211  1.00 55.06  ? 145 TYR B CB  1 
ATOM   2691 C CG  . TYR B 2 145 ? -8.869  1.259   23.087  1.00 53.28  ? 145 TYR B CG  1 
ATOM   2692 C CD1 . TYR B 2 145 ? -7.490  1.221   23.216  1.00 55.34  ? 145 TYR B CD1 1 
ATOM   2693 C CD2 . TYR B 2 145 ? -9.416  0.784   21.903  1.00 53.57  ? 145 TYR B CD2 1 
ATOM   2694 C CE1 . TYR B 2 145 ? -6.675  0.763   22.188  1.00 55.44  ? 145 TYR B CE1 1 
ATOM   2695 C CE2 . TYR B 2 145 ? -8.619  0.302   20.874  1.00 55.43  ? 145 TYR B CE2 1 
ATOM   2696 C CZ  . TYR B 2 145 ? -7.240  0.301   21.010  1.00 57.27  ? 145 TYR B CZ  1 
ATOM   2697 O OH  . TYR B 2 145 ? -6.427  -0.163  19.996  1.00 52.46  ? 145 TYR B OH  1 
ATOM   2698 N N   . PRO B 2 146 ? -8.149  -0.917  25.440  1.00 55.38  ? 146 PRO B N   1 
ATOM   2699 C CA  . PRO B 2 146 ? -8.707  -1.802  24.411  1.00 56.69  ? 146 PRO B CA  1 
ATOM   2700 C C   . PRO B 2 146 ? -9.841  -2.744  24.820  1.00 58.25  ? 146 PRO B C   1 
ATOM   2701 O O   . PRO B 2 146 ? -10.301 -2.757  25.963  1.00 61.57  ? 146 PRO B O   1 
ATOM   2702 C CB  . PRO B 2 146 ? -7.503  -2.665  23.982  1.00 53.85  ? 146 PRO B CB  1 
ATOM   2703 C CG  . PRO B 2 146 ? -6.556  -2.648  25.153  1.00 56.72  ? 146 PRO B CG  1 
ATOM   2704 C CD  . PRO B 2 146 ? -6.796  -1.324  25.848  1.00 55.57  ? 146 PRO B CD  1 
ATOM   2705 N N   . ARG B 2 147 ? -10.270 -3.543  23.840  1.00 54.19  ? 147 ARG B N   1 
ATOM   2706 C CA  . ARG B 2 147 ? -11.391 -4.459  23.963  1.00 54.40  ? 147 ARG B CA  1 
ATOM   2707 C C   . ARG B 2 147 ? -11.204 -5.383  25.170  1.00 51.33  ? 147 ARG B C   1 
ATOM   2708 O O   . ARG B 2 147 ? -12.161 -5.633  25.890  1.00 48.82  ? 147 ARG B O   1 
ATOM   2709 C CB  . ARG B 2 147 ? -11.531 -5.231  22.643  1.00 53.02  ? 147 ARG B CB  1 
ATOM   2710 C CG  . ARG B 2 147 ? -12.931 -5.726  22.312  1.00 56.80  ? 147 ARG B CG  1 
ATOM   2711 C CD  . ARG B 2 147 ? -13.083 -5.954  20.811  1.00 63.81  ? 147 ARG B CD  1 
ATOM   2712 N NE  . ARG B 2 147 ? -14.358 -6.552  20.426  1.00 68.20  ? 147 ARG B NE  1 
ATOM   2713 C CZ  . ARG B 2 147 ? -14.704 -7.824  20.632  1.00 82.09  ? 147 ARG B CZ  1 
ATOM   2714 N NH1 . ARG B 2 147 ? -13.832 -8.697  21.112  1.00 88.90  ? 147 ARG B NH1 1 
ATOM   2715 N NH2 . ARG B 2 147 ? -15.926 -8.229  20.325  1.00 83.91  ? 147 ARG B NH2 1 
ATOM   2716 N N   . GLU B 2 148 ? -9.978  -5.880  25.389  1.00 57.55  ? 148 GLU B N   1 
ATOM   2717 C CA  . GLU B 2 148 ? -9.697  -6.877  26.418  1.00 62.22  ? 148 GLU B CA  1 
ATOM   2718 C C   . GLU B 2 148 ? -10.226 -6.399  27.767  1.00 55.50  ? 148 GLU B C   1 
ATOM   2719 O O   . GLU B 2 148 ? -9.909  -5.305  28.218  1.00 51.00  ? 148 GLU B O   1 
ATOM   2720 C CB  . GLU B 2 148 ? -8.197  -7.160  26.561  1.00 68.14  ? 148 GLU B CB  1 
ATOM   2721 C CG  . GLU B 2 148 ? -7.633  -8.107  25.513  1.00 76.25  ? 148 GLU B CG  1 
ATOM   2722 C CD  . GLU B 2 148 ? -7.484  -7.557  24.099  1.00 84.44  ? 148 GLU B CD  1 
ATOM   2723 O OE1 . GLU B 2 148 ? -7.857  -6.386  23.857  1.00 77.61  ? 148 GLU B OE1 1 
ATOM   2724 O OE2 . GLU B 2 148 ? -6.987  -8.306  23.232  1.00 94.24  ? 148 GLU B OE2 1 
ATOM   2725 N N   . ALA B 2 149 ? -11.033 -7.242  28.407  1.00 52.87  ? 149 ALA B N   1 
ATOM   2726 C CA  . ALA B 2 149 ? -11.563 -6.943  29.723  1.00 53.11  ? 149 ALA B CA  1 
ATOM   2727 C C   . ALA B 2 149 ? -12.072 -8.240  30.328  1.00 54.04  ? 149 ALA B C   1 
ATOM   2728 O O   . ALA B 2 149 ? -12.623 -9.062  29.603  1.00 50.66  ? 149 ALA B O   1 
ATOM   2729 C CB  . ALA B 2 149 ? -12.666 -5.918  29.618  1.00 53.55  ? 149 ALA B CB  1 
ATOM   2730 N N   . LYS B 2 150 ? -11.840 -8.422  31.634  1.00 61.18  ? 150 LYS B N   1 
ATOM   2731 C CA  . LYS B 2 150 ? -12.364 -9.574  32.347  1.00 64.02  ? 150 LYS B CA  1 
ATOM   2732 C C   . LYS B 2 150 ? -13.468 -9.104  33.282  1.00 59.33  ? 150 LYS B C   1 
ATOM   2733 O O   . LYS B 2 150 ? -13.370 -8.049  33.900  1.00 62.90  ? 150 LYS B O   1 
ATOM   2734 C CB  . LYS B 2 150 ? -11.281 -10.321 33.134  1.00 72.60  ? 150 LYS B CB  1 
ATOM   2735 C CG  . LYS B 2 150 ? -11.632 -11.774 33.443  1.00 79.34  ? 150 LYS B CG  1 
ATOM   2736 C CD  . LYS B 2 150 ? -10.904 -12.378 34.626  1.00 82.91  ? 150 LYS B CD  1 
ATOM   2737 C CE  . LYS B 2 150 ? -9.413  -12.528 34.415  1.00 86.75  ? 150 LYS B CE  1 
ATOM   2738 N NZ  . LYS B 2 150 ? -8.750  -13.072 35.624  1.00 86.21  ? 150 LYS B NZ  1 
ATOM   2739 N N   . VAL B 2 151 ? -14.523 -9.909  33.363  1.00 58.59  ? 151 VAL B N   1 
ATOM   2740 C CA  . VAL B 2 151 ? -15.645 -9.616  34.229  1.00 55.26  ? 151 VAL B CA  1 
ATOM   2741 C C   . VAL B 2 151 ? -15.953 -10.880 35.012  1.00 58.08  ? 151 VAL B C   1 
ATOM   2742 O O   . VAL B 2 151 ? -16.445 -11.836 34.428  1.00 60.01  ? 151 VAL B O   1 
ATOM   2743 C CB  . VAL B 2 151 ? -16.867 -9.137  33.431  1.00 49.71  ? 151 VAL B CB  1 
ATOM   2744 C CG1 . VAL B 2 151 ? -18.138 -9.178  34.270  1.00 51.94  ? 151 VAL B CG1 1 
ATOM   2745 C CG2 . VAL B 2 151 ? -16.623 -7.746  32.871  1.00 50.22  ? 151 VAL B CG2 1 
ATOM   2746 N N   . GLN B 2 152 ? -15.628 -10.862 36.314  1.00 61.38  ? 152 GLN B N   1 
ATOM   2747 C CA  . GLN B 2 152 ? -15.920 -11.965 37.211  1.00 61.04  ? 152 GLN B CA  1 
ATOM   2748 C C   . GLN B 2 152 ? -17.071 -11.558 38.122  1.00 59.64  ? 152 GLN B C   1 
ATOM   2749 O O   . GLN B 2 152 ? -17.078 -10.454 38.666  1.00 54.97  ? 152 GLN B O   1 
ATOM   2750 C CB  . GLN B 2 152 ? -14.678 -12.375 38.006  1.00 67.27  ? 152 GLN B CB  1 
ATOM   2751 C CG  . GLN B 2 152 ? -13.515 -12.788 37.111  1.00 69.16  ? 152 GLN B CG  1 
ATOM   2752 C CD  . GLN B 2 152 ? -12.828 -14.050 37.578  1.00 73.42  ? 152 GLN B CD  1 
ATOM   2753 O OE1 . GLN B 2 152 ? -12.156 -14.070 38.605  1.00 79.09  ? 152 GLN B OE1 1 
ATOM   2754 N NE2 . GLN B 2 152 ? -12.989 -15.127 36.823  1.00 73.98  ? 152 GLN B NE2 1 
ATOM   2755 N N   . TRP B 2 153 ? -18.052 -12.462 38.227  1.00 55.06  ? 153 TRP B N   1 
ATOM   2756 C CA  . TRP B 2 153 ? -19.216 -12.282 39.075  1.00 60.13  ? 153 TRP B CA  1 
ATOM   2757 C C   . TRP B 2 153 ? -18.959 -12.958 40.419  1.00 61.04  ? 153 TRP B C   1 
ATOM   2758 O O   . TRP B 2 153 ? -18.415 -14.062 40.461  1.00 54.62  ? 153 TRP B O   1 
ATOM   2759 C CB  . TRP B 2 153 ? -20.471 -12.847 38.396  1.00 58.47  ? 153 TRP B CB  1 
ATOM   2760 C CG  . TRP B 2 153 ? -21.083 -11.941 37.372  1.00 57.95  ? 153 TRP B CG  1 
ATOM   2761 C CD1 . TRP B 2 153 ? -20.935 -12.024 36.018  1.00 57.62  ? 153 TRP B CD1 1 
ATOM   2762 C CD2 . TRP B 2 153 ? -21.970 -10.833 37.609  1.00 57.39  ? 153 TRP B CD2 1 
ATOM   2763 N NE1 . TRP B 2 153 ? -21.653 -11.038 35.399  1.00 54.52  ? 153 TRP B NE1 1 
ATOM   2764 C CE2 . TRP B 2 153 ? -22.302 -10.295 36.346  1.00 57.78  ? 153 TRP B CE2 1 
ATOM   2765 C CE3 . TRP B 2 153 ? -22.523 -10.245 38.753  1.00 56.47  ? 153 TRP B CE3 1 
ATOM   2766 C CZ2 . TRP B 2 153 ? -23.157 -9.201  36.199  1.00 56.45  ? 153 TRP B CZ2 1 
ATOM   2767 C CZ3 . TRP B 2 153 ? -23.366 -9.162  38.605  1.00 56.42  ? 153 TRP B CZ3 1 
ATOM   2768 C CH2 . TRP B 2 153 ? -23.675 -8.646  37.346  1.00 54.71  ? 153 TRP B CH2 1 
ATOM   2769 N N   . LYS B 2 154 ? -19.355 -12.277 41.504  1.00 62.27  ? 154 LYS B N   1 
ATOM   2770 C CA  . LYS B 2 154 ? -19.197 -12.791 42.857  1.00 58.71  ? 154 LYS B CA  1 
ATOM   2771 C C   . LYS B 2 154 ? -20.539 -12.691 43.576  1.00 54.39  ? 154 LYS B C   1 
ATOM   2772 O O   . LYS B 2 154 ? -21.121 -11.608 43.646  1.00 49.51  ? 154 LYS B O   1 
ATOM   2773 C CB  . LYS B 2 154 ? -18.090 -12.030 43.594  1.00 57.37  ? 154 LYS B CB  1 
ATOM   2774 C CG  . LYS B 2 154 ? -16.859 -11.714 42.754  1.00 62.65  ? 154 LYS B CG  1 
ATOM   2775 C CD  . LYS B 2 154 ? -15.543 -11.913 43.460  1.00 63.84  ? 154 LYS B CD  1 
ATOM   2776 C CE  . LYS B 2 154 ? -15.189 -13.378 43.607  1.00 61.86  ? 154 LYS B CE  1 
ATOM   2777 N NZ  . LYS B 2 154 ? -13.822 -13.543 44.151  1.00 65.27  ? 154 LYS B NZ  1 
ATOM   2778 N N   . VAL B 2 155 ? -21.031 -13.844 44.049  1.00 54.49  ? 155 VAL B N   1 
ATOM   2779 C CA  . VAL B 2 155 ? -22.219 -13.926 44.886  1.00 58.93  ? 155 VAL B CA  1 
ATOM   2780 C C   . VAL B 2 155 ? -21.804 -14.388 46.284  1.00 65.66  ? 155 VAL B C   1 
ATOM   2781 O O   . VAL B 2 155 ? -21.358 -15.526 46.453  1.00 66.23  ? 155 VAL B O   1 
ATOM   2782 C CB  . VAL B 2 155 ? -23.258 -14.886 44.284  1.00 59.18  ? 155 VAL B CB  1 
ATOM   2783 C CG1 . VAL B 2 155 ? -24.525 -14.947 45.127  1.00 59.52  ? 155 VAL B CG1 1 
ATOM   2784 C CG2 . VAL B 2 155 ? -23.590 -14.522 42.846  1.00 59.27  ? 155 VAL B CG2 1 
ATOM   2785 N N   . ASP B 2 156 ? -21.964 -13.498 47.276  1.00 63.56  ? 156 ASP B N   1 
ATOM   2786 C CA  . ASP B 2 156 ? -21.447 -13.704 48.625  1.00 64.05  ? 156 ASP B CA  1 
ATOM   2787 C C   . ASP B 2 156 ? -19.964 -14.078 48.550  1.00 59.92  ? 156 ASP B C   1 
ATOM   2788 O O   . ASP B 2 156 ? -19.474 -14.913 49.311  1.00 57.50  ? 156 ASP B O   1 
ATOM   2789 C CB  . ASP B 2 156 ? -22.325 -14.689 49.411  1.00 57.12  ? 156 ASP B CB  1 
ATOM   2790 C CG  . ASP B 2 156 ? -23.711 -14.135 49.709  1.00 57.28  ? 156 ASP B CG  1 
ATOM   2791 O OD1 . ASP B 2 156 ? -23.807 -12.919 49.984  1.00 53.63  ? 156 ASP B OD1 1 
ATOM   2792 O OD2 . ASP B 2 156 ? -24.683 -14.918 49.685  1.00 56.87  ? 156 ASP B OD2 1 
ATOM   2793 N N   . ASN B 2 157 ? -19.269 -13.429 47.609  1.00 60.64  ? 157 ASN B N   1 
ATOM   2794 C CA  . ASN B 2 157 ? -17.861 -13.663 47.338  1.00 60.18  ? 157 ASN B CA  1 
ATOM   2795 C C   . ASN B 2 157 ? -17.611 -15.093 46.844  1.00 55.89  ? 157 ASN B C   1 
ATOM   2796 O O   . ASN B 2 157 ? -16.501 -15.597 46.968  1.00 52.72  ? 157 ASN B O   1 
ATOM   2797 C CB  . ASN B 2 157 ? -17.000 -13.351 48.563  1.00 60.69  ? 157 ASN B CB  1 
ATOM   2798 C CG  . ASN B 2 157 ? -15.564 -13.061 48.182  1.00 62.60  ? 157 ASN B CG  1 
ATOM   2799 O OD1 . ASN B 2 157 ? -14.682 -13.902 48.353  1.00 63.25  ? 157 ASN B OD1 1 
ATOM   2800 N ND2 . ASN B 2 157 ? -15.334 -11.889 47.615  1.00 63.81  ? 157 ASN B ND2 1 
ATOM   2801 N N   . ALA B 2 158 ? -18.635 -15.747 46.280  1.00 54.78  ? 158 ALA B N   1 
ATOM   2802 C CA  . ALA B 2 158 ? -18.461 -17.042 45.643  1.00 57.20  ? 158 ALA B CA  1 
ATOM   2803 C C   . ALA B 2 158 ? -18.391 -16.826 44.127  1.00 61.01  ? 158 ALA B C   1 
ATOM   2804 O O   . ALA B 2 158 ? -19.334 -16.299 43.532  1.00 61.11  ? 158 ALA B O   1 
ATOM   2805 C CB  . ALA B 2 158 ? -19.585 -17.975 46.050  1.00 53.40  ? 158 ALA B CB  1 
ATOM   2806 N N   . LEU B 2 159 ? -17.254 -17.199 43.516  1.00 59.96  ? 159 LEU B N   1 
ATOM   2807 C CA  . LEU B 2 159 ? -16.995 -16.908 42.113  1.00 58.98  ? 159 LEU B CA  1 
ATOM   2808 C C   . LEU B 2 159 ? -17.926 -17.743 41.231  1.00 54.73  ? 159 LEU B C   1 
ATOM   2809 O O   . LEU B 2 159 ? -18.115 -18.930 41.471  1.00 48.00  ? 159 LEU B O   1 
ATOM   2810 C CB  . LEU B 2 159 ? -15.514 -17.166 41.806  1.00 61.50  ? 159 LEU B CB  1 
ATOM   2811 C CG  . LEU B 2 159 ? -15.111 -17.059 40.331  1.00 66.20  ? 159 LEU B CG  1 
ATOM   2812 C CD1 . LEU B 2 159 ? -15.243 -15.628 39.813  1.00 63.03  ? 159 LEU B CD1 1 
ATOM   2813 C CD2 . LEU B 2 159 ? -13.693 -17.584 40.108  1.00 65.53  ? 159 LEU B CD2 1 
ATOM   2814 N N   . GLN B 2 160 ? -18.526 -17.098 40.218  1.00 58.05  ? 160 GLN B N   1 
ATOM   2815 C CA  . GLN B 2 160 ? -19.555 -17.715 39.387  1.00 56.34  ? 160 GLN B CA  1 
ATOM   2816 C C   . GLN B 2 160 ? -18.944 -18.265 38.102  1.00 50.92  ? 160 GLN B C   1 
ATOM   2817 O O   . GLN B 2 160 ? -18.085 -17.621 37.505  1.00 49.79  ? 160 GLN B O   1 
ATOM   2818 C CB  . GLN B 2 160 ? -20.629 -16.691 39.015  1.00 58.27  ? 160 GLN B CB  1 
ATOM   2819 C CG  . GLN B 2 160 ? -21.321 -16.067 40.217  1.00 57.33  ? 160 GLN B CG  1 
ATOM   2820 C CD  . GLN B 2 160 ? -22.061 -17.096 41.037  1.00 59.25  ? 160 GLN B CD  1 
ATOM   2821 O OE1 . GLN B 2 160 ? -22.979 -17.757 40.554  1.00 52.79  ? 160 GLN B OE1 1 
ATOM   2822 N NE2 . GLN B 2 160 ? -21.660 -17.246 42.291  1.00 64.27  ? 160 GLN B NE2 1 
ATOM   2823 N N   . SER B 2 161 ? -19.399 -19.460 37.700  1.00 49.12  ? 161 SER B N   1 
ATOM   2824 C CA  . SER B 2 161 ? -19.041 -20.042 36.414  1.00 51.41  ? 161 SER B CA  1 
ATOM   2825 C C   . SER B 2 161 ? -20.286 -20.569 35.704  1.00 51.41  ? 161 SER B C   1 
ATOM   2826 O O   . SER B 2 161 ? -21.103 -21.264 36.305  1.00 55.65  ? 161 SER B O   1 
ATOM   2827 C CB  . SER B 2 161 ? -18.006 -21.123 36.568  1.00 50.89  ? 161 SER B CB  1 
ATOM   2828 O OG  . SER B 2 161 ? -16.722 -20.541 36.730  1.00 51.16  ? 161 SER B OG  1 
ATOM   2829 N N   . GLY B 2 162 ? -20.428 -20.189 34.428  1.00 50.06  ? 162 GLY B N   1 
ATOM   2830 C CA  . GLY B 2 162 ? -21.350 -20.838 33.511  1.00 48.06  ? 162 GLY B CA  1 
ATOM   2831 C C   . GLY B 2 162 ? -22.766 -20.272 33.568  1.00 47.58  ? 162 GLY B C   1 
ATOM   2832 O O   . GLY B 2 162 ? -23.707 -20.923 33.137  1.00 51.36  ? 162 GLY B O   1 
ATOM   2833 N N   . ASN B 2 163 ? -22.928 -19.059 34.093  1.00 52.86  ? 163 ASN B N   1 
ATOM   2834 C CA  . ASN B 2 163 ? -24.260 -18.492 34.256  1.00 52.41  ? 163 ASN B CA  1 
ATOM   2835 C C   . ASN B 2 163 ? -24.248 -16.999 33.923  1.00 48.71  ? 163 ASN B C   1 
ATOM   2836 O O   . ASN B 2 163 ? -25.188 -16.278 34.267  1.00 46.60  ? 163 ASN B O   1 
ATOM   2837 C CB  . ASN B 2 163 ? -24.785 -18.782 35.666  1.00 51.84  ? 163 ASN B CB  1 
ATOM   2838 C CG  . ASN B 2 163 ? -23.842 -18.304 36.754  1.00 51.29  ? 163 ASN B CG  1 
ATOM   2839 O OD1 . ASN B 2 163 ? -22.732 -17.838 36.473  1.00 47.27  ? 163 ASN B OD1 1 
ATOM   2840 N ND2 . ASN B 2 163 ? -24.285 -18.407 37.999  1.00 50.04  ? 163 ASN B ND2 1 
ATOM   2841 N N   . SER B 2 164 ? -23.182 -16.544 33.253  1.00 42.95  ? 164 SER B N   1 
ATOM   2842 C CA  . SER B 2 164 ? -23.117 -15.189 32.752  1.00 44.27  ? 164 SER B CA  1 
ATOM   2843 C C   . SER B 2 164 ? -22.834 -15.230 31.253  1.00 44.30  ? 164 SER B C   1 
ATOM   2844 O O   . SER B 2 164 ? -22.106 -16.109 30.795  1.00 42.08  ? 164 SER B O   1 
ATOM   2845 C CB  . SER B 2 164 ? -22.081 -14.390 33.487  1.00 42.39  ? 164 SER B CB  1 
ATOM   2846 O OG  . SER B 2 164 ? -20.794 -14.909 33.234  1.00 40.01  ? 164 SER B OG  1 
ATOM   2847 N N   . GLN B 2 165 ? -23.444 -14.292 30.511  1.00 44.55  ? 165 GLN B N   1 
ATOM   2848 C CA  . GLN B 2 165 ? -23.179 -14.105 29.092  1.00 45.80  ? 165 GLN B CA  1 
ATOM   2849 C C   . GLN B 2 165 ? -22.782 -12.651 28.864  1.00 45.69  ? 165 GLN B C   1 
ATOM   2850 O O   . GLN B 2 165 ? -23.474 -11.750 29.329  1.00 50.01  ? 165 GLN B O   1 
ATOM   2851 C CB  . GLN B 2 165 ? -24.398 -14.475 28.245  1.00 43.71  ? 165 GLN B CB  1 
ATOM   2852 C CG  . GLN B 2 165 ? -24.594 -15.977 28.092  1.00 45.44  ? 165 GLN B CG  1 
ATOM   2853 C CD  . GLN B 2 165 ? -25.752 -16.320 27.183  1.00 45.81  ? 165 GLN B CD  1 
ATOM   2854 O OE1 . GLN B 2 165 ? -26.909 -16.032 27.466  1.00 46.63  ? 165 GLN B OE1 1 
ATOM   2855 N NE2 . GLN B 2 165 ? -25.452 -16.957 26.067  1.00 49.99  ? 165 GLN B NE2 1 
ATOM   2856 N N   . GLU B 2 166 ? -21.671 -12.464 28.142  1.00 42.37  ? 166 GLU B N   1 
ATOM   2857 C CA  . GLU B 2 166 ? -21.121 -11.163 27.804  1.00 43.67  ? 166 GLU B CA  1 
ATOM   2858 C C   . GLU B 2 166 ? -21.516 -10.763 26.386  1.00 43.45  ? 166 GLU B C   1 
ATOM   2859 O O   . GLU B 2 166 ? -21.914 -11.602 25.594  1.00 42.82  ? 166 GLU B O   1 
ATOM   2860 C CB  . GLU B 2 166 ? -19.597 -11.196 27.785  1.00 44.38  ? 166 GLU B CB  1 
ATOM   2861 C CG  . GLU B 2 166 ? -18.972 -11.705 29.059  1.00 53.09  ? 166 GLU B CG  1 
ATOM   2862 C CD  . GLU B 2 166 ? -17.555 -11.192 29.235  1.00 57.49  ? 166 GLU B CD  1 
ATOM   2863 O OE1 . GLU B 2 166 ? -17.070 -10.482 28.310  1.00 56.03  ? 166 GLU B OE1 1 
ATOM   2864 O OE2 . GLU B 2 166 ? -16.950 -11.484 30.295  1.00 59.17  ? 166 GLU B OE2 1 
ATOM   2865 N N   . SER B 2 167 ? -21.305 -9.483  26.062  1.00 40.01  ? 167 SER B N   1 
ATOM   2866 C CA  . SER B 2 167 ? -21.638 -8.921  24.768  1.00 41.05  ? 167 SER B CA  1 
ATOM   2867 C C   . SER B 2 167 ? -20.919 -7.580  24.672  1.00 39.49  ? 167 SER B C   1 
ATOM   2868 O O   . SER B 2 167 ? -20.815 -6.877  25.673  1.00 36.35  ? 167 SER B O   1 
ATOM   2869 C CB  . SER B 2 167 ? -23.150 -8.836  24.614  1.00 45.53  ? 167 SER B CB  1 
ATOM   2870 O OG  . SER B 2 167 ? -23.566 -7.787  23.751  1.00 46.73  ? 167 SER B OG  1 
ATOM   2871 N N   . VAL B 2 168 ? -20.351 -7.277  23.498  1.00 37.73  ? 168 VAL B N   1 
ATOM   2872 C CA  . VAL B 2 168 ? -19.541 -6.083  23.313  1.00 38.61  ? 168 VAL B CA  1 
ATOM   2873 C C   . VAL B 2 168 ? -20.098 -5.295  22.128  1.00 43.38  ? 168 VAL B C   1 
ATOM   2874 O O   . VAL B 2 168 ? -20.357 -5.883  21.077  1.00 39.93  ? 168 VAL B O   1 
ATOM   2875 C CB  . VAL B 2 168 ? -18.063 -6.453  23.102  1.00 39.89  ? 168 VAL B CB  1 
ATOM   2876 C CG1 . VAL B 2 168 ? -17.152 -5.239  23.193  1.00 39.64  ? 168 VAL B CG1 1 
ATOM   2877 C CG2 . VAL B 2 168 ? -17.598 -7.521  24.081  1.00 41.62  ? 168 VAL B CG2 1 
ATOM   2878 N N   . THR B 2 169 ? -20.316 -3.981  22.315  1.00 46.66  ? 169 THR B N   1 
ATOM   2879 C CA  . THR B 2 169 ? -20.650 -3.100  21.205  1.00 49.59  ? 169 THR B CA  1 
ATOM   2880 C C   . THR B 2 169 ? -19.494 -3.095  20.206  1.00 52.92  ? 169 THR B C   1 
ATOM   2881 O O   . THR B 2 169 ? -18.346 -3.365  20.559  1.00 50.60  ? 169 THR B O   1 
ATOM   2882 C CB  . THR B 2 169 ? -20.891 -1.623  21.578  1.00 48.30  ? 169 THR B CB  1 
ATOM   2883 O OG1 . THR B 2 169 ? -19.670 -1.076  22.078  1.00 44.76  ? 169 THR B OG1 1 
ATOM   2884 C CG2 . THR B 2 169 ? -22.009 -1.385  22.571  1.00 48.41  ? 169 THR B CG2 1 
ATOM   2885 N N   . GLU B 2 170 ? -19.828 -2.763  18.956  1.00 56.52  ? 170 GLU B N   1 
ATOM   2886 C CA  . GLU B 2 170 ? -18.842 -2.420  17.950  1.00 57.79  ? 170 GLU B CA  1 
ATOM   2887 C C   . GLU B 2 170 ? -18.102 -1.188  18.438  1.00 54.77  ? 170 GLU B C   1 
ATOM   2888 O O   . GLU B 2 170 ? -18.603 -0.480  19.304  1.00 55.25  ? 170 GLU B O   1 
ATOM   2889 C CB  . GLU B 2 170 ? -19.529 -2.163  16.605  1.00 64.62  ? 170 GLU B CB  1 
ATOM   2890 C CG  . GLU B 2 170 ? -19.985 -3.438  15.907  1.00 66.25  ? 170 GLU B CG  1 
ATOM   2891 C CD  . GLU B 2 170 ? -18.847 -4.259  15.317  1.00 71.35  ? 170 GLU B CD  1 
ATOM   2892 O OE1 . GLU B 2 170 ? -18.512 -5.314  15.901  1.00 69.21  ? 170 GLU B OE1 1 
ATOM   2893 O OE2 . GLU B 2 170 ? -18.291 -3.839  14.271  1.00 77.91  ? 170 GLU B OE2 1 
ATOM   2894 N N   . GLN B 2 171 ? -16.913 -0.947  17.892  1.00 48.82  ? 171 GLN B N   1 
ATOM   2895 C CA  . GLN B 2 171 ? -16.192 0.262   18.231  1.00 52.29  ? 171 GLN B CA  1 
ATOM   2896 C C   . GLN B 2 171 ? -17.049 1.458   17.823  1.00 53.38  ? 171 GLN B C   1 
ATOM   2897 O O   . GLN B 2 171 ? -17.674 1.440   16.768  1.00 58.60  ? 171 GLN B O   1 
ATOM   2898 C CB  . GLN B 2 171 ? -14.821 0.260   17.560  1.00 49.37  ? 171 GLN B CB  1 
ATOM   2899 C CG  . GLN B 2 171 ? -13.879 1.303   18.120  1.00 52.87  ? 171 GLN B CG  1 
ATOM   2900 C CD  . GLN B 2 171 ? -12.471 1.026   17.665  1.00 50.72  ? 171 GLN B CD  1 
ATOM   2901 O OE1 . GLN B 2 171 ? -12.214 0.914   16.474  1.00 56.06  ? 171 GLN B OE1 1 
ATOM   2902 N NE2 . GLN B 2 171 ? -11.554 0.877   18.605  1.00 49.35  ? 171 GLN B NE2 1 
ATOM   2903 N N   . ASP B 2 172 ? -17.087 2.480   18.683  1.00 54.37  ? 172 ASP B N   1 
ATOM   2904 C CA  . ASP B 2 172 ? -17.938 3.642   18.485  1.00 58.38  ? 172 ASP B CA  1 
ATOM   2905 C C   . ASP B 2 172 ? -17.262 4.592   17.495  1.00 56.09  ? 172 ASP B C   1 
ATOM   2906 O O   . ASP B 2 172 ? -16.065 4.850   17.599  1.00 56.66  ? 172 ASP B O   1 
ATOM   2907 C CB  . ASP B 2 172 ? -18.227 4.337   19.821  1.00 62.33  ? 172 ASP B CB  1 
ATOM   2908 C CG  . ASP B 2 172 ? -18.959 5.659   19.666  1.00 62.91  ? 172 ASP B CG  1 
ATOM   2909 O OD1 . ASP B 2 172 ? -20.185 5.617   19.464  1.00 66.06  ? 172 ASP B OD1 1 
ATOM   2910 O OD2 . ASP B 2 172 ? -18.286 6.711   19.698  1.00 54.79  ? 172 ASP B OD2 1 
ATOM   2911 N N   . SER B 2 173 ? -18.059 5.145   16.569  1.00 57.97  ? 173 SER B N   1 
ATOM   2912 C CA  . SER B 2 173 ? -17.538 5.823   15.389  1.00 56.50  ? 173 SER B CA  1 
ATOM   2913 C C   . SER B 2 173 ? -17.220 7.285   15.687  1.00 57.54  ? 173 SER B C   1 
ATOM   2914 O O   . SER B 2 173 ? -16.742 7.998   14.806  1.00 47.15  ? 173 SER B O   1 
ATOM   2915 C CB  . SER B 2 173 ? -18.497 5.714   14.234  1.00 54.37  ? 173 SER B CB  1 
ATOM   2916 O OG  . SER B 2 173 ? -19.757 6.279   14.562  1.00 55.62  ? 173 SER B OG  1 
ATOM   2917 N N   . LYS B 2 174 ? -17.477 7.711   16.930  1.00 61.83  ? 174 LYS B N   1 
ATOM   2918 C CA  . LYS B 2 174 ? -17.290 9.094   17.331  1.00 62.12  ? 174 LYS B CA  1 
ATOM   2919 C C   . LYS B 2 174 ? -16.062 9.179   18.242  1.00 57.56  ? 174 LYS B C   1 
ATOM   2920 O O   . LYS B 2 174 ? -15.247 10.073  18.035  1.00 59.64  ? 174 LYS B O   1 
ATOM   2921 C CB  . LYS B 2 174 ? -18.635 9.612   17.862  1.00 69.14  ? 174 LYS B CB  1 
ATOM   2922 C CG  . LYS B 2 174 ? -18.630 10.899  18.678  1.00 80.04  ? 174 LYS B CG  1 
ATOM   2923 C CD  . LYS B 2 174 ? -20.041 11.422  18.973  1.00 82.63  ? 174 LYS B CD  1 
ATOM   2924 C CE  . LYS B 2 174 ? -20.154 12.238  20.248  1.00 84.82  ? 174 LYS B CE  1 
ATOM   2925 N NZ  . LYS B 2 174 ? -20.194 11.380  21.459  1.00 85.52  ? 174 LYS B NZ  1 
ATOM   2926 N N   . ASP B 2 175 ? -15.872 8.226   19.180  1.00 58.63  ? 175 ASP B N   1 
ATOM   2927 C CA  . ASP B 2 175 ? -14.757 8.291   20.134  1.00 55.62  ? 175 ASP B CA  1 
ATOM   2928 C C   . ASP B 2 175 ? -13.918 7.007   20.223  1.00 52.62  ? 175 ASP B C   1 
ATOM   2929 O O   . ASP B 2 175 ? -13.003 6.946   21.042  1.00 53.77  ? 175 ASP B O   1 
ATOM   2930 C CB  . ASP B 2 175 ? -15.243 8.589   21.554  1.00 60.64  ? 175 ASP B CB  1 
ATOM   2931 C CG  . ASP B 2 175 ? -15.869 7.381   22.240  1.00 64.66  ? 175 ASP B CG  1 
ATOM   2932 O OD1 . ASP B 2 175 ? -17.004 7.019   21.867  1.00 67.43  ? 175 ASP B OD1 1 
ATOM   2933 O OD2 . ASP B 2 175 ? -15.195 6.779   23.110  1.00 58.86  ? 175 ASP B OD2 1 
ATOM   2934 N N   . SER B 2 176 ? -14.222 5.965   19.435  1.00 49.11  ? 176 SER B N   1 
ATOM   2935 C CA  . SER B 2 176 ? -13.296 4.850   19.247  1.00 48.54  ? 176 SER B CA  1 
ATOM   2936 C C   . SER B 2 176 ? -13.168 3.947   20.483  1.00 49.14  ? 176 SER B C   1 
ATOM   2937 O O   . SER B 2 176 ? -12.114 3.344   20.656  1.00 46.18  ? 176 SER B O   1 
ATOM   2938 C CB  . SER B 2 176 ? -11.908 5.352   18.840  1.00 44.04  ? 176 SER B CB  1 
ATOM   2939 O OG  . SER B 2 176 ? -11.972 6.331   17.815  1.00 39.87  ? 176 SER B OG  1 
ATOM   2940 N N   . THR B 2 177 ? -14.220 3.832   21.320  1.00 52.11  ? 177 THR B N   1 
ATOM   2941 C CA  . THR B 2 177 ? -14.213 2.982   22.513  1.00 48.34  ? 177 THR B CA  1 
ATOM   2942 C C   . THR B 2 177 ? -15.200 1.833   22.346  1.00 42.99  ? 177 THR B C   1 
ATOM   2943 O O   . THR B 2 177 ? -16.048 1.886   21.467  1.00 44.53  ? 177 THR B O   1 
ATOM   2944 C CB  . THR B 2 177 ? -14.656 3.693   23.812  1.00 50.73  ? 177 THR B CB  1 
ATOM   2945 O OG1 . THR B 2 177 ? -15.923 4.325   23.608  1.00 48.93  ? 177 THR B OG1 1 
ATOM   2946 C CG2 . THR B 2 177 ? -13.658 4.701   24.330  1.00 47.91  ? 177 THR B CG2 1 
ATOM   2947 N N   . TYR B 2 178 ? -15.090 0.820   23.219  1.00 41.40  ? 178 TYR B N   1 
ATOM   2948 C CA  . TYR B 2 178 ? -16.069 -0.257  23.314  1.00 48.23  ? 178 TYR B CA  1 
ATOM   2949 C C   . TYR B 2 178 ? -16.852 -0.171  24.633  1.00 46.89  ? 178 TYR B C   1 
ATOM   2950 O O   . TYR B 2 178 ? -16.439 0.474   25.590  1.00 48.70  ? 178 TYR B O   1 
ATOM   2951 C CB  . TYR B 2 178 ? -15.387 -1.630  23.211  1.00 51.16  ? 178 TYR B CB  1 
ATOM   2952 C CG  . TYR B 2 178 ? -14.434 -1.794  22.052  1.00 52.07  ? 178 TYR B CG  1 
ATOM   2953 C CD1 . TYR B 2 178 ? -13.125 -1.345  22.137  1.00 52.44  ? 178 TYR B CD1 1 
ATOM   2954 C CD2 . TYR B 2 178 ? -14.842 -2.387  20.866  1.00 51.07  ? 178 TYR B CD2 1 
ATOM   2955 C CE1 . TYR B 2 178 ? -12.247 -1.478  21.073  1.00 57.14  ? 178 TYR B CE1 1 
ATOM   2956 C CE2 . TYR B 2 178 ? -13.974 -2.530  19.793  1.00 51.51  ? 178 TYR B CE2 1 
ATOM   2957 C CZ  . TYR B 2 178 ? -12.673 -2.073  19.898  1.00 52.45  ? 178 TYR B CZ  1 
ATOM   2958 O OH  . TYR B 2 178 ? -11.800 -2.204  18.858  1.00 55.01  ? 178 TYR B OH  1 
ATOM   2959 N N   . SER B 2 179 ? -17.991 -0.860  24.684  1.00 50.71  ? 179 SER B N   1 
ATOM   2960 C CA  . SER B 2 179 ? -18.716 -1.058  25.927  1.00 52.48  ? 179 SER B CA  1 
ATOM   2961 C C   . SER B 2 179 ? -19.100 -2.525  26.021  1.00 53.17  ? 179 SER B C   1 
ATOM   2962 O O   . SER B 2 179 ? -19.285 -3.168  24.990  1.00 54.76  ? 179 SER B O   1 
ATOM   2963 C CB  . SER B 2 179 ? -19.910 -0.148  25.993  1.00 52.80  ? 179 SER B CB  1 
ATOM   2964 O OG  . SER B 2 179 ? -19.482 1.201   25.864  1.00 49.73  ? 179 SER B OG  1 
ATOM   2965 N N   . LEU B 2 180 ? -19.193 -3.046  27.249  1.00 51.05  ? 180 LEU B N   1 
ATOM   2966 C CA  . LEU B 2 180 ? -19.403 -4.471  27.443  1.00 50.04  ? 180 LEU B CA  1 
ATOM   2967 C C   . LEU B 2 180 ? -20.474 -4.690  28.501  1.00 50.09  ? 180 LEU B C   1 
ATOM   2968 O O   . LEU B 2 180 ? -20.373 -4.162  29.602  1.00 57.97  ? 180 LEU B O   1 
ATOM   2969 C CB  . LEU B 2 180 ? -18.072 -5.125  27.832  1.00 46.60  ? 180 LEU B CB  1 
ATOM   2970 C CG  . LEU B 2 180 ? -18.111 -6.631  28.085  1.00 47.45  ? 180 LEU B CG  1 
ATOM   2971 C CD1 . LEU B 2 180 ? -16.733 -7.239  27.869  1.00 48.36  ? 180 LEU B CD1 1 
ATOM   2972 C CD2 . LEU B 2 180 ? -18.604 -6.945  29.495  1.00 49.35  ? 180 LEU B CD2 1 
ATOM   2973 N N   . SER B 2 181 ? -21.484 -5.494  28.163  1.00 47.71  ? 181 SER B N   1 
ATOM   2974 C CA  . SER B 2 181 ? -22.527 -5.825  29.111  1.00 46.72  ? 181 SER B CA  1 
ATOM   2975 C C   . SER B 2 181 ? -22.367 -7.285  29.500  1.00 46.62  ? 181 SER B C   1 
ATOM   2976 O O   . SER B 2 181 ? -22.310 -8.137  28.621  1.00 44.46  ? 181 SER B O   1 
ATOM   2977 C CB  . SER B 2 181 ? -23.896 -5.555  28.561  1.00 43.60  ? 181 SER B CB  1 
ATOM   2978 O OG  . SER B 2 181 ? -24.378 -6.676  27.843  1.00 52.89  ? 181 SER B OG  1 
ATOM   2979 N N   . SER B 2 182 ? -22.294 -7.553  30.812  1.00 47.13  ? 182 SER B N   1 
ATOM   2980 C CA  . SER B 2 182 ? -22.359 -8.917  31.313  1.00 46.69  ? 182 SER B CA  1 
ATOM   2981 C C   . SER B 2 182 ? -23.665 -9.112  32.072  1.00 47.45  ? 182 SER B C   1 
ATOM   2982 O O   . SER B 2 182 ? -24.050 -8.264  32.868  1.00 55.05  ? 182 SER B O   1 
ATOM   2983 C CB  . SER B 2 182 ? -21.163 -9.244  32.160  1.00 47.59  ? 182 SER B CB  1 
ATOM   2984 O OG  . SER B 2 182 ? -21.133 -10.631 32.449  1.00 47.37  ? 182 SER B OG  1 
ATOM   2985 N N   . THR B 2 183 ? -24.356 -10.215 31.785  1.00 44.75  ? 183 THR B N   1 
ATOM   2986 C CA  . THR B 2 183 ? -25.582 -10.564 32.468  1.00 44.20  ? 183 THR B CA  1 
ATOM   2987 C C   . THR B 2 183 ? -25.411 -11.892 33.199  1.00 48.50  ? 183 THR B C   1 
ATOM   2988 O O   . THR B 2 183 ? -25.160 -12.929 32.580  1.00 43.57  ? 183 THR B O   1 
ATOM   2989 C CB  . THR B 2 183 ? -26.769 -10.710 31.514  1.00 46.63  ? 183 THR B CB  1 
ATOM   2990 O OG1 . THR B 2 183 ? -26.896 -9.463  30.845  1.00 47.23  ? 183 THR B OG1 1 
ATOM   2991 C CG2 . THR B 2 183 ? -28.066 -11.064 32.213  1.00 45.97  ? 183 THR B CG2 1 
ATOM   2992 N N   . LEU B 2 184 ? -25.607 -11.823 34.521  1.00 51.25  ? 184 LEU B N   1 
ATOM   2993 C CA  . LEU B 2 184 ? -25.733 -12.982 35.385  1.00 50.82  ? 184 LEU B CA  1 
ATOM   2994 C C   . LEU B 2 184 ? -27.208 -13.358 35.491  1.00 52.99  ? 184 LEU B C   1 
ATOM   2995 O O   . LEU B 2 184 ? -28.052 -12.527 35.837  1.00 55.83  ? 184 LEU B O   1 
ATOM   2996 C CB  . LEU B 2 184 ? -25.142 -12.613 36.749  1.00 56.11  ? 184 LEU B CB  1 
ATOM   2997 C CG  . LEU B 2 184 ? -25.015 -13.748 37.763  1.00 61.52  ? 184 LEU B CG  1 
ATOM   2998 C CD1 . LEU B 2 184 ? -23.834 -14.644 37.431  1.00 62.21  ? 184 LEU B CD1 1 
ATOM   2999 C CD2 . LEU B 2 184 ? -24.874 -13.190 39.172  1.00 68.10  ? 184 LEU B CD2 1 
ATOM   3000 N N   . THR B 2 185 ? -27.498 -14.626 35.197  1.00 55.46  ? 185 THR B N   1 
ATOM   3001 C CA  . THR B 2 185 ? -28.860 -15.125 35.167  1.00 59.96  ? 185 THR B CA  1 
ATOM   3002 C C   . THR B 2 185 ? -28.995 -16.246 36.194  1.00 62.46  ? 185 THR B C   1 
ATOM   3003 O O   . THR B 2 185 ? -28.148 -17.136 36.259  1.00 61.50  ? 185 THR B O   1 
ATOM   3004 C CB  . THR B 2 185 ? -29.228 -15.531 33.735  1.00 65.34  ? 185 THR B CB  1 
ATOM   3005 O OG1 . THR B 2 185 ? -28.943 -14.381 32.939  1.00 66.31  ? 185 THR B OG1 1 
ATOM   3006 C CG2 . THR B 2 185 ? -30.675 -15.945 33.559  1.00 69.19  ? 185 THR B CG2 1 
ATOM   3007 N N   . LEU B 2 186 ? -30.068 -16.165 36.999  1.00 67.30  ? 186 LEU B N   1 
ATOM   3008 C CA  . LEU B 2 186 ? -30.359 -17.100 38.077  1.00 61.91  ? 186 LEU B CA  1 
ATOM   3009 C C   . LEU B 2 186 ? -31.868 -17.250 38.226  1.00 61.76  ? 186 LEU B C   1 
ATOM   3010 O O   . LEU B 2 186 ? -32.606 -16.296 37.996  1.00 58.85  ? 186 LEU B O   1 
ATOM   3011 C CB  . LEU B 2 186 ? -29.786 -16.534 39.376  1.00 62.10  ? 186 LEU B CB  1 
ATOM   3012 C CG  . LEU B 2 186 ? -28.269 -16.389 39.417  1.00 64.06  ? 186 LEU B CG  1 
ATOM   3013 C CD1 . LEU B 2 186 ? -27.849 -15.647 40.674  1.00 64.74  ? 186 LEU B CD1 1 
ATOM   3014 C CD2 . LEU B 2 186 ? -27.593 -17.754 39.333  1.00 63.95  ? 186 LEU B CD2 1 
ATOM   3015 N N   . SER B 2 187 ? -32.313 -18.436 38.657  1.00 61.78  ? 187 SER B N   1 
ATOM   3016 C CA  . SER B 2 187 ? -33.690 -18.614 39.091  1.00 65.45  ? 187 SER B CA  1 
ATOM   3017 C C   . SER B 2 187 ? -33.992 -17.635 40.229  1.00 68.56  ? 187 SER B C   1 
ATOM   3018 O O   . SER B 2 187 ? -33.088 -17.223 40.958  1.00 61.80  ? 187 SER B O   1 
ATOM   3019 C CB  . SER B 2 187 ? -33.945 -20.042 39.504  1.00 65.51  ? 187 SER B CB  1 
ATOM   3020 O OG  . SER B 2 187 ? -33.127 -20.405 40.610  1.00 67.39  ? 187 SER B OG  1 
ATOM   3021 N N   . LYS B 2 188 ? -35.264 -17.237 40.354  1.00 69.29  ? 188 LYS B N   1 
ATOM   3022 C CA  . LYS B 2 188 ? -35.704 -16.447 41.495  1.00 71.06  ? 188 LYS B CA  1 
ATOM   3023 C C   . LYS B 2 188 ? -35.191 -17.090 42.782  1.00 71.85  ? 188 LYS B C   1 
ATOM   3024 O O   . LYS B 2 188 ? -34.610 -16.410 43.622  1.00 69.74  ? 188 LYS B O   1 
ATOM   3025 C CB  . LYS B 2 188 ? -37.232 -16.362 41.546  1.00 74.19  ? 188 LYS B CB  1 
ATOM   3026 C CG  . LYS B 2 188 ? -37.795 -15.336 42.523  1.00 79.01  ? 188 LYS B CG  1 
ATOM   3027 C CD  . LYS B 2 188 ? -39.292 -15.448 42.707  1.00 75.50  ? 188 LYS B CD  1 
ATOM   3028 C CE  . LYS B 2 188 ? -39.875 -14.337 43.553  1.00 74.33  ? 188 LYS B CE  1 
ATOM   3029 N NZ  . LYS B 2 188 ? -41.344 -14.252 43.382  1.00 69.92  ? 188 LYS B NZ  1 
ATOM   3030 N N   . ALA B 2 189 ? -35.405 -18.410 42.897  1.00 69.17  ? 189 ALA B N   1 
ATOM   3031 C CA  . ALA B 2 189 ? -34.918 -19.212 44.008  1.00 68.36  ? 189 ALA B CA  1 
ATOM   3032 C C   . ALA B 2 189 ? -33.486 -18.820 44.375  1.00 65.74  ? 189 ALA B C   1 
ATOM   3033 O O   . ALA B 2 189 ? -33.270 -18.262 45.444  1.00 70.17  ? 189 ALA B O   1 
ATOM   3034 C CB  . ALA B 2 189 ? -35.032 -20.680 43.667  1.00 63.88  ? 189 ALA B CB  1 
ATOM   3035 N N   . ASP B 2 190 ? -32.523 -19.064 43.475  1.00 67.70  ? 190 ASP B N   1 
ATOM   3036 C CA  . ASP B 2 190 ? -31.103 -18.908 43.781  1.00 66.99  ? 190 ASP B CA  1 
ATOM   3037 C C   . ASP B 2 190 ? -30.752 -17.472 44.162  1.00 62.91  ? 190 ASP B C   1 
ATOM   3038 O O   . ASP B 2 190 ? -29.803 -17.252 44.915  1.00 63.05  ? 190 ASP B O   1 
ATOM   3039 C CB  . ASP B 2 190 ? -30.226 -19.360 42.612  1.00 70.39  ? 190 ASP B CB  1 
ATOM   3040 C CG  . ASP B 2 190 ? -30.246 -20.861 42.377  1.00 71.01  ? 190 ASP B CG  1 
ATOM   3041 O OD1 . ASP B 2 190 ? -30.698 -21.595 43.282  1.00 63.79  ? 190 ASP B OD1 1 
ATOM   3042 O OD2 . ASP B 2 190 ? -29.819 -21.281 41.285  1.00 70.68  ? 190 ASP B OD2 1 
ATOM   3043 N N   . TYR B 2 191 ? -31.507 -16.510 43.621  1.00 59.41  ? 191 TYR B N   1 
ATOM   3044 C CA  . TYR B 2 191 ? -31.300 -15.103 43.909  1.00 61.25  ? 191 TYR B CA  1 
ATOM   3045 C C   . TYR B 2 191 ? -31.682 -14.811 45.365  1.00 64.76  ? 191 TYR B C   1 
ATOM   3046 O O   . TYR B 2 191 ? -31.114 -13.912 45.977  1.00 65.03  ? 191 TYR B O   1 
ATOM   3047 C CB  . TYR B 2 191 ? -32.060 -14.249 42.889  1.00 56.79  ? 191 TYR B CB  1 
ATOM   3048 C CG  . TYR B 2 191 ? -31.908 -12.762 43.078  1.00 56.68  ? 191 TYR B CG  1 
ATOM   3049 C CD1 . TYR B 2 191 ? -30.664 -12.159 42.962  1.00 52.03  ? 191 TYR B CD1 1 
ATOM   3050 C CD2 . TYR B 2 191 ? -33.001 -11.956 43.379  1.00 55.23  ? 191 TYR B CD2 1 
ATOM   3051 C CE1 . TYR B 2 191 ? -30.504 -10.795 43.138  1.00 51.90  ? 191 TYR B CE1 1 
ATOM   3052 C CE2 . TYR B 2 191 ? -32.860 -10.585 43.548  1.00 55.11  ? 191 TYR B CE2 1 
ATOM   3053 C CZ  . TYR B 2 191 ? -31.604 -10.010 43.435  1.00 54.42  ? 191 TYR B CZ  1 
ATOM   3054 O OH  . TYR B 2 191 ? -31.402 -8.667  43.608  1.00 62.03  ? 191 TYR B OH  1 
ATOM   3055 N N   . GLU B 2 192 ? -32.623 -15.583 45.931  1.00 69.47  ? 192 GLU B N   1 
ATOM   3056 C CA  . GLU B 2 192 ? -33.060 -15.394 47.312  1.00 73.43  ? 192 GLU B CA  1 
ATOM   3057 C C   . GLU B 2 192 ? -32.098 -16.078 48.287  1.00 68.85  ? 192 GLU B C   1 
ATOM   3058 O O   . GLU B 2 192 ? -32.034 -15.684 49.446  1.00 76.72  ? 192 GLU B O   1 
ATOM   3059 C CB  . GLU B 2 192 ? -34.472 -15.945 47.555  1.00 77.15  ? 192 GLU B CB  1 
ATOM   3060 C CG  . GLU B 2 192 ? -35.518 -15.488 46.547  1.00 80.78  ? 192 GLU B CG  1 
ATOM   3061 C CD  . GLU B 2 192 ? -36.165 -14.137 46.799  1.00 82.06  ? 192 GLU B CD  1 
ATOM   3062 O OE1 . GLU B 2 192 ? -37.417 -14.080 46.795  1.00 75.68  ? 192 GLU B OE1 1 
ATOM   3063 O OE2 . GLU B 2 192 ? -35.419 -13.145 46.974  1.00 85.37  ? 192 GLU B OE2 1 
ATOM   3064 N N   . LYS B 2 193 ? -31.348 -17.091 47.826  1.00 63.16  ? 193 LYS B N   1 
ATOM   3065 C CA  . LYS B 2 193 ? -30.450 -17.852 48.687  1.00 63.50  ? 193 LYS B CA  1 
ATOM   3066 C C   . LYS B 2 193 ? -29.141 -17.100 48.951  1.00 63.56  ? 193 LYS B C   1 
ATOM   3067 O O   . LYS B 2 193 ? -28.229 -17.670 49.545  1.00 68.58  ? 193 LYS B O   1 
ATOM   3068 C CB  . LYS B 2 193 ? -30.112 -19.221 48.072  1.00 66.08  ? 193 LYS B CB  1 
ATOM   3069 C CG  . LYS B 2 193 ? -31.279 -20.185 47.891  1.00 72.03  ? 193 LYS B CG  1 
ATOM   3070 C CD  . LYS B 2 193 ? -30.944 -21.409 47.039  1.00 78.07  ? 193 LYS B CD  1 
ATOM   3071 C CE  . LYS B 2 193 ? -32.083 -22.402 46.872  1.00 81.73  ? 193 LYS B CE  1 
ATOM   3072 N NZ  . LYS B 2 193 ? -33.424 -21.765 46.915  1.00 85.72  ? 193 LYS B NZ  1 
ATOM   3073 N N   . HIS B 2 194 ? -29.019 -15.836 48.520  1.00 60.49  ? 194 HIS B N   1 
ATOM   3074 C CA  . HIS B 2 194 ? -27.761 -15.112 48.661  1.00 61.92  ? 194 HIS B CA  1 
ATOM   3075 C C   . HIS B 2 194 ? -28.047 -13.623 48.810  1.00 57.31  ? 194 HIS B C   1 
ATOM   3076 O O   . HIS B 2 194 ? -29.197 -13.217 48.656  1.00 52.85  ? 194 HIS B O   1 
ATOM   3077 C CB  . HIS B 2 194 ? -26.844 -15.415 47.471  1.00 67.99  ? 194 HIS B CB  1 
ATOM   3078 C CG  . HIS B 2 194 ? -26.356 -16.824 47.444  1.00 73.71  ? 194 HIS B CG  1 
ATOM   3079 N ND1 . HIS B 2 194 ? -26.935 -17.776 46.631  1.00 76.97  ? 194 HIS B ND1 1 
ATOM   3080 C CD2 . HIS B 2 194 ? -25.396 -17.454 48.137  1.00 72.29  ? 194 HIS B CD2 1 
ATOM   3081 C CE1 . HIS B 2 194 ? -26.323 -18.937 46.813  1.00 77.96  ? 194 HIS B CE1 1 
ATOM   3082 N NE2 . HIS B 2 194 ? -25.384 -18.763 47.723  1.00 80.08  ? 194 HIS B NE2 1 
ATOM   3083 N N   . LYS B 2 195 ? -27.002 -12.815 49.072  1.00 55.28  ? 195 LYS B N   1 
ATOM   3084 C CA  . LYS B 2 195 ? -27.203 -11.441 49.524  1.00 61.74  ? 195 LYS B CA  1 
ATOM   3085 C C   . LYS B 2 195 ? -26.412 -10.419 48.695  1.00 53.30  ? 195 LYS B C   1 
ATOM   3086 O O   . LYS B 2 195 ? -27.018 -9.520  48.108  1.00 52.62  ? 195 LYS B O   1 
ATOM   3087 C CB  . LYS B 2 195 ? -26.860 -11.344 51.016  1.00 64.63  ? 195 LYS B CB  1 
ATOM   3088 C CG  . LYS B 2 195 ? -26.522 -9.953  51.551  1.00 71.34  ? 195 LYS B CG  1 
ATOM   3089 C CD  . LYS B 2 195 ? -27.729 -9.076  51.847  1.00 81.78  ? 195 LYS B CD  1 
ATOM   3090 C CE  . LYS B 2 195 ? -27.553 -8.199  53.074  1.00 82.71  ? 195 LYS B CE  1 
ATOM   3091 N NZ  . LYS B 2 195 ? -27.114 -8.983  54.254  1.00 82.16  ? 195 LYS B NZ  1 
ATOM   3092 N N   . LEU B 2 196 ? -25.072 -10.492 48.753  1.00 50.60  ? 196 LEU B N   1 
ATOM   3093 C CA  . LEU B 2 196 ? -24.187 -9.553  48.073  1.00 49.49  ? 196 LEU B CA  1 
ATOM   3094 C C   . LEU B 2 196 ? -23.875 -10.041 46.654  1.00 55.49  ? 196 LEU B C   1 
ATOM   3095 O O   . LEU B 2 196 ? -23.219 -11.071 46.472  1.00 51.39  ? 196 LEU B O   1 
ATOM   3096 C CB  . LEU B 2 196 ? -22.892 -9.404  48.875  1.00 45.08  ? 196 LEU B CB  1 
ATOM   3097 C CG  . LEU B 2 196 ? -21.869 -8.425  48.293  1.00 49.42  ? 196 LEU B CG  1 
ATOM   3098 C CD1 . LEU B 2 196 ? -22.313 -6.983  48.498  1.00 52.87  ? 196 LEU B CD1 1 
ATOM   3099 C CD2 . LEU B 2 196 ? -20.478 -8.643  48.879  1.00 46.89  ? 196 LEU B CD2 1 
ATOM   3100 N N   . TYR B 2 197 ? -24.338 -9.271  45.657  1.00 63.28  ? 197 TYR B N   1 
ATOM   3101 C CA  . TYR B 2 197 ? -24.040 -9.518  44.252  1.00 57.11  ? 197 TYR B CA  1 
ATOM   3102 C C   . TYR B 2 197 ? -23.044 -8.478  43.752  1.00 52.39  ? 197 TYR B C   1 
ATOM   3103 O O   . TYR B 2 197 ? -23.312 -7.278  43.828  1.00 46.75  ? 197 TYR B O   1 
ATOM   3104 C CB  . TYR B 2 197 ? -25.335 -9.503  43.445  1.00 54.16  ? 197 TYR B CB  1 
ATOM   3105 C CG  . TYR B 2 197 ? -26.262 -10.635 43.797  1.00 58.11  ? 197 TYR B CG  1 
ATOM   3106 C CD1 . TYR B 2 197 ? -27.059 -10.581 44.927  1.00 61.48  ? 197 TYR B CD1 1 
ATOM   3107 C CD2 . TYR B 2 197 ? -26.309 -11.782 43.024  1.00 56.35  ? 197 TYR B CD2 1 
ATOM   3108 C CE1 . TYR B 2 197 ? -27.907 -11.626 45.258  1.00 59.10  ? 197 TYR B CE1 1 
ATOM   3109 C CE2 . TYR B 2 197 ? -27.149 -12.833 43.340  1.00 55.66  ? 197 TYR B CE2 1 
ATOM   3110 C CZ  . TYR B 2 197 ? -27.943 -12.757 44.467  1.00 57.53  ? 197 TYR B CZ  1 
ATOM   3111 O OH  . TYR B 2 197 ? -28.763 -13.805 44.784  1.00 59.18  ? 197 TYR B OH  1 
ATOM   3112 N N   . ALA B 2 198 ? -21.901 -8.963  43.245  1.00 56.12  ? 198 ALA B N   1 
ATOM   3113 C CA  . ALA B 2 198 ? -20.787 -8.119  42.840  1.00 61.46  ? 198 ALA B CA  1 
ATOM   3114 C C   . ALA B 2 198 ? -20.254 -8.538  41.466  1.00 65.40  ? 198 ALA B C   1 
ATOM   3115 O O   . ALA B 2 198 ? -20.235 -9.726  41.152  1.00 62.50  ? 198 ALA B O   1 
ATOM   3116 C CB  . ALA B 2 198 ? -19.696 -8.220  43.873  1.00 59.12  ? 198 ALA B CB  1 
ATOM   3117 N N   . CYS B 2 199 ? -19.790 -7.556  40.671  1.00 68.74  ? 199 CYS B N   1 
ATOM   3118 C CA  . CYS B 2 199 ? -19.014 -7.821  39.466  1.00 63.69  ? 199 CYS B CA  1 
ATOM   3119 C C   . CYS B 2 199 ? -17.669 -7.109  39.571  1.00 57.11  ? 199 CYS B C   1 
ATOM   3120 O O   . CYS B 2 199 ? -17.625 -5.908  39.798  1.00 52.82  ? 199 CYS B O   1 
ATOM   3121 C CB  . CYS B 2 199 ? -19.753 -7.415  38.191  1.00 70.99  ? 199 CYS B CB  1 
ATOM   3122 S SG  . CYS B 2 199 ? -19.963 -5.629  37.950  1.00 79.77  ? 199 CYS B SG  1 
ATOM   3123 N N   . GLU B 2 200 ? -16.586 -7.873  39.384  1.00 58.40  ? 200 GLU B N   1 
ATOM   3124 C CA  . GLU B 2 200 ? -15.218 -7.391  39.503  1.00 61.31  ? 200 GLU B CA  1 
ATOM   3125 C C   . GLU B 2 200 ? -14.568 -7.399  38.121  1.00 56.29  ? 200 GLU B C   1 
ATOM   3126 O O   . GLU B 2 200 ? -14.699 -8.380  37.401  1.00 55.33  ? 200 GLU B O   1 
ATOM   3127 C CB  . GLU B 2 200 ? -14.453 -8.315  40.457  1.00 72.82  ? 200 GLU B CB  1 
ATOM   3128 C CG  . GLU B 2 200 ? -12.946 -8.087  40.526  1.00 73.64  ? 200 GLU B CG  1 
ATOM   3129 C CD  . GLU B 2 200 ? -12.153 -9.377  40.657  1.00 77.03  ? 200 GLU B CD  1 
ATOM   3130 O OE1 . GLU B 2 200 ? -11.852 -10.013 39.606  1.00 70.90  ? 200 GLU B OE1 1 
ATOM   3131 O OE2 . GLU B 2 200 ? -11.878 -9.771  41.807  1.00 80.41  ? 200 GLU B OE2 1 
ATOM   3132 N N   . VAL B 2 201 ? -13.802 -6.345  37.812  1.00 55.46  ? 201 VAL B N   1 
ATOM   3133 C CA  . VAL B 2 201 ? -13.393 -6.019  36.455  1.00 57.26  ? 201 VAL B CA  1 
ATOM   3134 C C   . VAL B 2 201 ? -11.873 -5.881  36.391  1.00 61.20  ? 201 VAL B C   1 
ATOM   3135 O O   . VAL B 2 201 ? -11.262 -5.287  37.270  1.00 63.87  ? 201 VAL B O   1 
ATOM   3136 C CB  . VAL B 2 201 ? -14.087 -4.720  35.998  1.00 58.27  ? 201 VAL B CB  1 
ATOM   3137 C CG1 . VAL B 2 201 ? -13.630 -4.280  34.620  1.00 58.28  ? 201 VAL B CG1 1 
ATOM   3138 C CG2 . VAL B 2 201 ? -15.603 -4.840  36.039  1.00 61.64  ? 201 VAL B CG2 1 
ATOM   3139 N N   . THR B 2 202 ? -11.262 -6.399  35.322  1.00 65.83  ? 202 THR B N   1 
ATOM   3140 C CA  . THR B 2 202 ? -9.825  -6.273  35.128  1.00 69.08  ? 202 THR B CA  1 
ATOM   3141 C C   . THR B 2 202 ? -9.552  -5.598  33.795  1.00 68.23  ? 202 THR B C   1 
ATOM   3142 O O   . THR B 2 202 ? -10.242 -5.853  32.810  1.00 65.99  ? 202 THR B O   1 
ATOM   3143 C CB  . THR B 2 202 ? -9.104  -7.629  35.182  1.00 76.46  ? 202 THR B CB  1 
ATOM   3144 O OG1 . THR B 2 202 ? -9.106  -8.053  36.547  1.00 74.35  ? 202 THR B OG1 1 
ATOM   3145 C CG2 . THR B 2 202 ? -7.679  -7.583  34.667  1.00 74.27  ? 202 THR B CG2 1 
ATOM   3146 N N   . HIS B 2 203 ? -8.514  -4.759  33.788  1.00 70.66  ? 203 HIS B N   1 
ATOM   3147 C CA  . HIS B 2 203 ? -8.179  -3.955  32.629  1.00 72.93  ? 203 HIS B CA  1 
ATOM   3148 C C   . HIS B 2 203 ? -6.755  -3.421  32.778  1.00 73.22  ? 203 HIS B C   1 
ATOM   3149 O O   . HIS B 2 203 ? -6.160  -3.512  33.850  1.00 77.24  ? 203 HIS B O   1 
ATOM   3150 C CB  . HIS B 2 203 ? -9.211  -2.836  32.464  1.00 72.69  ? 203 HIS B CB  1 
ATOM   3151 C CG  . HIS B 2 203 ? -9.284  -2.294  31.082  1.00 79.88  ? 203 HIS B CG  1 
ATOM   3152 N ND1 . HIS B 2 203 ? -8.992  -0.987  30.753  1.00 84.65  ? 203 HIS B ND1 1 
ATOM   3153 C CD2 . HIS B 2 203 ? -9.613  -2.903  29.939  1.00 81.99  ? 203 HIS B CD2 1 
ATOM   3154 C CE1 . HIS B 2 203 ? -9.148  -0.825  29.447  1.00 84.28  ? 203 HIS B CE1 1 
ATOM   3155 N NE2 . HIS B 2 203 ? -9.524  -1.978  28.931  1.00 80.67  ? 203 HIS B NE2 1 
ATOM   3156 N N   . GLN B 2 204 ? -6.212  -2.892  31.678  1.00 73.61  ? 204 GLN B N   1 
ATOM   3157 C CA  . GLN B 2 204 ? -4.926  -2.213  31.682  1.00 73.51  ? 204 GLN B CA  1 
ATOM   3158 C C   . GLN B 2 204 ? -5.080  -0.770  32.146  1.00 72.65  ? 204 GLN B C   1 
ATOM   3159 O O   . GLN B 2 204 ? -4.133  -0.194  32.673  1.00 76.59  ? 204 GLN B O   1 
ATOM   3160 C CB  . GLN B 2 204 ? -4.328  -2.187  30.280  1.00 79.58  ? 204 GLN B CB  1 
ATOM   3161 C CG  . GLN B 2 204 ? -3.765  -3.520  29.822  1.00 79.56  ? 204 GLN B CG  1 
ATOM   3162 C CD  . GLN B 2 204 ? -3.649  -3.522  28.320  1.00 79.51  ? 204 GLN B CD  1 
ATOM   3163 O OE1 . GLN B 2 204 ? -4.066  -4.468  27.654  1.00 75.43  ? 204 GLN B OE1 1 
ATOM   3164 N NE2 . GLN B 2 204 ? -3.109  -2.439  27.777  1.00 73.22  ? 204 GLN B NE2 1 
ATOM   3165 N N   . GLY B 2 205 ? -6.262  -0.183  31.920  1.00 69.83  ? 205 GLY B N   1 
ATOM   3166 C CA  . GLY B 2 205 ? -6.572  1.135   32.443  1.00 71.12  ? 205 GLY B CA  1 
ATOM   3167 C C   . GLY B 2 205 ? -6.949  1.095   33.926  1.00 78.15  ? 205 GLY B C   1 
ATOM   3168 O O   . GLY B 2 205 ? -7.709  1.951   34.371  1.00 77.49  ? 205 GLY B O   1 
ATOM   3169 N N   . LEU B 2 206 ? -6.431  0.093   34.663  1.00 77.35  ? 206 LEU B N   1 
ATOM   3170 C CA  . LEU B 2 206 ? -6.649  -0.084  36.097  1.00 73.49  ? 206 LEU B CA  1 
ATOM   3171 C C   . LEU B 2 206 ? -5.391  -0.704  36.710  1.00 78.39  ? 206 LEU B C   1 
ATOM   3172 O O   . LEU B 2 206 ? -4.977  -1.779  36.277  1.00 73.86  ? 206 LEU B O   1 
ATOM   3173 C CB  . LEU B 2 206 ? -7.832  -1.028  36.342  1.00 66.81  ? 206 LEU B CB  1 
ATOM   3174 C CG  . LEU B 2 206 ? -9.190  -0.619  35.768  1.00 69.12  ? 206 LEU B CG  1 
ATOM   3175 C CD1 . LEU B 2 206 ? -10.215 -1.730  35.987  1.00 68.28  ? 206 LEU B CD1 1 
ATOM   3176 C CD2 . LEU B 2 206 ? -9.692  0.683   36.376  1.00 66.15  ? 206 LEU B CD2 1 
ATOM   3177 N N   . SER B 2 207 ? -4.795  -0.047  37.722  1.00 82.84  ? 207 SER B N   1 
ATOM   3178 C CA  . SER B 2 207 ? -3.639  -0.611  38.415  1.00 85.72  ? 207 SER B CA  1 
ATOM   3179 C C   . SER B 2 207 ? -4.081  -1.841  39.210  1.00 87.37  ? 207 SER B C   1 
ATOM   3180 O O   . SER B 2 207 ? -3.300  -2.772  39.413  1.00 87.68  ? 207 SER B O   1 
ATOM   3181 C CB  . SER B 2 207 ? -2.935  0.398   39.313  1.00 81.99  ? 207 SER B CB  1 
ATOM   3182 O OG  . SER B 2 207 ? -3.343  0.264   40.673  1.00 83.12  ? 207 SER B OG  1 
ATOM   3183 N N   . SER B 2 208 ? -5.341  -1.817  39.664  1.00 79.63  ? 208 SER B N   1 
ATOM   3184 C CA  . SER B 2 208 ? -5.958  -2.976  40.283  1.00 73.94  ? 208 SER B CA  1 
ATOM   3185 C C   . SER B 2 208 ? -7.471  -2.979  40.042  1.00 66.45  ? 208 SER B C   1 
ATOM   3186 O O   . SER B 2 208 ? -8.069  -1.935  39.759  1.00 57.32  ? 208 SER B O   1 
ATOM   3187 C CB  . SER B 2 208 ? -5.599  -3.044  41.748  1.00 74.32  ? 208 SER B CB  1 
ATOM   3188 O OG  . SER B 2 208 ? -5.463  -1.741  42.295  1.00 78.39  ? 208 SER B OG  1 
ATOM   3189 N N   . PRO B 2 209 ? -8.109  -4.176  40.106  1.00 60.91  ? 209 PRO B N   1 
ATOM   3190 C CA  . PRO B 2 209 ? -9.531  -4.354  39.790  1.00 58.35  ? 209 PRO B CA  1 
ATOM   3191 C C   . PRO B 2 209 ? -10.536 -3.455  40.499  1.00 56.20  ? 209 PRO B C   1 
ATOM   3192 O O   . PRO B 2 209 ? -10.279 -2.965  41.589  1.00 63.37  ? 209 PRO B O   1 
ATOM   3193 C CB  . PRO B 2 209 ? -9.814  -5.805  40.223  1.00 56.10  ? 209 PRO B CB  1 
ATOM   3194 C CG  . PRO B 2 209 ? -8.490  -6.509  40.027  1.00 60.25  ? 209 PRO B CG  1 
ATOM   3195 C CD  . PRO B 2 209 ? -7.444  -5.467  40.374  1.00 62.31  ? 209 PRO B CD  1 
ATOM   3196 N N   . VAL B 2 210 ? -11.707 -3.305  39.877  1.00 60.73  ? 210 VAL B N   1 
ATOM   3197 C CA  . VAL B 2 210 ? -12.757 -2.428  40.368  1.00 63.83  ? 210 VAL B CA  1 
ATOM   3198 C C   . VAL B 2 210 ? -14.014 -3.267  40.568  1.00 68.95  ? 210 VAL B C   1 
ATOM   3199 O O   . VAL B 2 210 ? -14.384 -4.045  39.689  1.00 75.34  ? 210 VAL B O   1 
ATOM   3200 C CB  . VAL B 2 210 ? -13.008 -1.273  39.381  1.00 62.93  ? 210 VAL B CB  1 
ATOM   3201 C CG1 . VAL B 2 210 ? -14.166 -0.381  39.821  1.00 58.92  ? 210 VAL B CG1 1 
ATOM   3202 C CG2 . VAL B 2 210 ? -11.742 -0.460  39.153  1.00 62.17  ? 210 VAL B CG2 1 
ATOM   3203 N N   . THR B 2 211 ? -14.659 -3.107  41.729  1.00 61.27  ? 211 THR B N   1 
ATOM   3204 C CA  . THR B 2 211 ? -15.856 -3.868  42.035  1.00 58.63  ? 211 THR B CA  1 
ATOM   3205 C C   . THR B 2 211 ? -17.031 -2.908  42.133  1.00 57.95  ? 211 THR B C   1 
ATOM   3206 O O   . THR B 2 211 ? -16.854 -1.743  42.462  1.00 65.58  ? 211 THR B O   1 
ATOM   3207 C CB  . THR B 2 211 ? -15.676 -4.698  43.312  1.00 59.75  ? 211 THR B CB  1 
ATOM   3208 O OG1 . THR B 2 211 ? -14.632 -5.641  43.070  1.00 60.42  ? 211 THR B OG1 1 
ATOM   3209 C CG2 . THR B 2 211 ? -16.925 -5.442  43.735  1.00 60.35  ? 211 THR B CG2 1 
ATOM   3210 N N   . LYS B 2 212 ? -18.220 -3.411  41.803  1.00 57.19  ? 212 LYS B N   1 
ATOM   3211 C CA  . LYS B 2 212 ? -19.466 -2.750  42.139  1.00 62.33  ? 212 LYS B CA  1 
ATOM   3212 C C   . LYS B 2 212 ? -20.414 -3.829  42.640  1.00 67.41  ? 212 LYS B C   1 
ATOM   3213 O O   . LYS B 2 212 ? -20.614 -4.829  41.949  1.00 70.43  ? 212 LYS B O   1 
ATOM   3214 C CB  . LYS B 2 212 ? -20.102 -2.056  40.932  1.00 65.50  ? 212 LYS B CB  1 
ATOM   3215 C CG  . LYS B 2 212 ? -19.190 -1.135  40.136  1.00 72.29  ? 212 LYS B CG  1 
ATOM   3216 C CD  . LYS B 2 212 ? -18.864 0.183   40.809  1.00 76.74  ? 212 LYS B CD  1 
ATOM   3217 C CE  . LYS B 2 212 ? -17.636 0.825   40.193  1.00 77.58  ? 212 LYS B CE  1 
ATOM   3218 N NZ  . LYS B 2 212 ? -17.343 2.154   40.774  1.00 78.36  ? 212 LYS B NZ  1 
ATOM   3219 N N   . SER B 2 213 ? -20.965 -3.626  43.844  1.00 65.29  ? 213 SER B N   1 
ATOM   3220 C CA  . SER B 2 213 ? -21.919 -4.561  44.417  1.00 62.00  ? 213 SER B CA  1 
ATOM   3221 C C   . SER B 2 213 ? -23.175 -3.827  44.874  1.00 57.09  ? 213 SER B C   1 
ATOM   3222 O O   . SER B 2 213 ? -23.177 -2.616  45.035  1.00 48.95  ? 213 SER B O   1 
ATOM   3223 C CB  . SER B 2 213 ? -21.307 -5.377  45.537  1.00 62.17  ? 213 SER B CB  1 
ATOM   3224 O OG  . SER B 2 213 ? -20.506 -4.587  46.408  1.00 61.97  ? 213 SER B OG  1 
ATOM   3225 N N   . PHE B 2 214 ? -24.257 -4.592  45.012  1.00 59.98  ? 214 PHE B N   1 
ATOM   3226 C CA  . PHE B 2 214 ? -25.436 -4.173  45.743  1.00 61.08  ? 214 PHE B CA  1 
ATOM   3227 C C   . PHE B 2 214 ? -25.818 -5.305  46.697  1.00 65.88  ? 214 PHE B C   1 
ATOM   3228 O O   . PHE B 2 214 ? -25.341 -6.432  46.535  1.00 64.22  ? 214 PHE B O   1 
ATOM   3229 C CB  . PHE B 2 214 ? -26.584 -3.863  44.785  1.00 57.51  ? 214 PHE B CB  1 
ATOM   3230 C CG  . PHE B 2 214 ? -27.083 -5.067  44.028  1.00 60.67  ? 214 PHE B CG  1 
ATOM   3231 C CD1 . PHE B 2 214 ? -26.385 -5.558  42.934  1.00 57.25  ? 214 PHE B CD1 1 
ATOM   3232 C CD2 . PHE B 2 214 ? -28.230 -5.737  44.432  1.00 62.93  ? 214 PHE B CD2 1 
ATOM   3233 C CE1 . PHE B 2 214 ? -26.841 -6.672  42.247  1.00 52.77  ? 214 PHE B CE1 1 
ATOM   3234 C CE2 . PHE B 2 214 ? -28.689 -6.847  43.739  1.00 62.38  ? 214 PHE B CE2 1 
ATOM   3235 C CZ  . PHE B 2 214 ? -27.990 -7.314  42.648  1.00 59.08  ? 214 PHE B CZ  1 
ATOM   3236 N N   . ASN B 2 215 ? -26.672 -4.992  47.683  1.00 62.95  ? 215 ASN B N   1 
ATOM   3237 C CA  . ASN B 2 215 ? -27.236 -5.993  48.577  1.00 64.56  ? 215 ASN B CA  1 
ATOM   3238 C C   . ASN B 2 215 ? -28.714 -6.163  48.239  1.00 62.02  ? 215 ASN B C   1 
ATOM   3239 O O   . ASN B 2 215 ? -29.442 -5.176  48.157  1.00 59.43  ? 215 ASN B O   1 
ATOM   3240 C CB  . ASN B 2 215 ? -27.013 -5.623  50.048  1.00 63.97  ? 215 ASN B CB  1 
ATOM   3241 C CG  . ASN B 2 215 ? -25.568 -5.779  50.480  1.00 64.89  ? 215 ASN B CG  1 
ATOM   3242 O OD1 . ASN B 2 215 ? -25.062 -6.894  50.611  1.00 70.53  ? 215 ASN B OD1 1 
ATOM   3243 N ND2 . ASN B 2 215 ? -24.885 -4.668  50.701  1.00 68.82  ? 215 ASN B ND2 1 
ATOM   3244 N N   . ARG B 2 216 ? -29.136 -7.419  48.050  1.00 59.45  ? 216 ARG B N   1 
ATOM   3245 C CA  . ARG B 2 216 ? -30.477 -7.735  47.573  1.00 66.28  ? 216 ARG B CA  1 
ATOM   3246 C C   . ARG B 2 216 ? -31.562 -7.025  48.394  1.00 73.04  ? 216 ARG B C   1 
ATOM   3247 O O   . ARG B 2 216 ? -32.083 -7.582  49.352  1.00 75.19  ? 216 ARG B O   1 
ATOM   3248 C CB  . ARG B 2 216 ? -30.668 -9.255  47.582  1.00 65.52  ? 216 ARG B CB  1 
ATOM   3249 C CG  . ARG B 2 216 ? -32.095 -9.707  47.300  1.00 69.43  ? 216 ARG B CG  1 
ATOM   3250 C CD  . ARG B 2 216 ? -32.169 -11.169 46.907  1.00 71.10  ? 216 ARG B CD  1 
ATOM   3251 N NE  . ARG B 2 216 ? -31.552 -12.052 47.884  1.00 74.14  ? 216 ARG B NE  1 
ATOM   3252 C CZ  . ARG B 2 216 ? -32.029 -12.289 49.102  1.00 78.40  ? 216 ARG B CZ  1 
ATOM   3253 N NH1 . ARG B 2 216 ? -33.160 -11.732 49.500  1.00 76.13  ? 216 ARG B NH1 1 
ATOM   3254 N NH2 . ARG B 2 216 ? -31.374 -13.097 49.918  1.00 79.56  ? 216 ARG B NH2 1 
ATOM   3255 N N   . GLY B 2 217 ? -31.931 -5.800  47.988  1.00 82.89  ? 217 GLY B N   1 
ATOM   3256 C CA  . GLY B 2 217 ? -33.029 -5.060  48.601  1.00 81.72  ? 217 GLY B CA  1 
ATOM   3257 C C   . GLY B 2 217 ? -32.657 -4.461  49.951  1.00 79.18  ? 217 GLY B C   1 
ATOM   3258 O O   . GLY B 2 217 ? -31.730 -3.614  49.981  1.00 70.79  ? 217 GLY B O   1 
ATOM   3259 N N   . GLN C 1 1   ? 32.936  11.291  26.603  1.00 53.69  ? 1   GLN H N   1 
ATOM   3260 C CA  . GLN C 1 1   ? 32.266  12.221  25.653  1.00 50.01  ? 1   GLN H CA  1 
ATOM   3261 C C   . GLN C 1 1   ? 30.752  12.241  25.922  1.00 37.56  ? 1   GLN H C   1 
ATOM   3262 O O   . GLN C 1 1   ? 30.129  13.309  25.941  1.00 36.85  ? 1   GLN H O   1 
ATOM   3263 C CB  . GLN C 1 1   ? 32.628  11.828  24.218  1.00 53.91  ? 1   GLN H CB  1 
ATOM   3264 C CG  . GLN C 1 1   ? 32.799  13.026  23.293  1.00 65.14  ? 1   GLN H CG  1 
ATOM   3265 C CD  . GLN C 1 1   ? 32.475  12.705  21.853  1.00 74.27  ? 1   GLN H CD  1 
ATOM   3266 O OE1 . GLN C 1 1   ? 32.160  11.570  21.501  1.00 73.35  ? 1   GLN H OE1 1 
ATOM   3267 N NE2 . GLN C 1 1   ? 32.517  13.721  21.005  1.00 78.38  ? 1   GLN H NE2 1 
ATOM   3268 N N   . VAL C 1 2   ? 30.160  11.057  26.131  1.00 33.18  ? 2   VAL H N   1 
ATOM   3269 C CA  . VAL C 1 2   ? 28.728  10.930  26.366  1.00 29.40  ? 2   VAL H CA  1 
ATOM   3270 C C   . VAL C 1 2   ? 28.429  11.299  27.812  1.00 26.80  ? 2   VAL H C   1 
ATOM   3271 O O   . VAL C 1 2   ? 29.054  10.753  28.695  1.00 24.77  ? 2   VAL H O   1 
ATOM   3272 C CB  . VAL C 1 2   ? 28.203  9.516   26.062  1.00 28.68  ? 2   VAL H CB  1 
ATOM   3273 C CG1 . VAL C 1 2   ? 26.723  9.371   26.420  1.00 28.68  ? 2   VAL H CG1 1 
ATOM   3274 C CG2 . VAL C 1 2   ? 28.426  9.139   24.607  1.00 29.55  ? 2   VAL H CG2 1 
ATOM   3275 N N   . GLN C 1 3   ? 27.449  12.197  27.995  1.00 25.22  ? 3   GLN H N   1 
ATOM   3276 C CA  . GLN C 1 3   ? 26.931  12.629  29.277  1.00 26.92  ? 3   GLN H CA  1 
ATOM   3277 C C   . GLN C 1 3   ? 25.417  12.801  29.218  1.00 22.68  ? 3   GLN H C   1 
ATOM   3278 O O   . GLN C 1 3   ? 24.890  13.248  28.212  1.00 19.31  ? 3   GLN H O   1 
ATOM   3279 C CB  . GLN C 1 3   ? 27.449  14.020  29.628  1.00 34.64  ? 3   GLN H CB  1 
ATOM   3280 C CG  . GLN C 1 3   ? 28.906  14.033  30.057  1.00 41.54  ? 3   GLN H CG  1 
ATOM   3281 C CD  . GLN C 1 3   ? 29.197  15.374  30.675  1.00 46.88  ? 3   GLN H CD  1 
ATOM   3282 O OE1 . GLN C 1 3   ? 29.271  16.388  29.982  1.00 53.47  ? 3   GLN H OE1 1 
ATOM   3283 N NE2 . GLN C 1 3   ? 29.303  15.395  31.993  1.00 47.00  ? 3   GLN H NE2 1 
ATOM   3284 N N   . LEU C 1 4   ? 24.755  12.407  30.311  1.00 21.04  ? 4   LEU H N   1 
ATOM   3285 C CA  . LEU C 1 4   ? 23.383  12.729  30.612  1.00 19.86  ? 4   LEU H CA  1 
ATOM   3286 C C   . LEU C 1 4   ? 23.394  13.610  31.842  1.00 20.69  ? 4   LEU H C   1 
ATOM   3287 O O   . LEU C 1 4   ? 23.836  13.135  32.886  1.00 20.69  ? 4   LEU H O   1 
ATOM   3288 C CB  . LEU C 1 4   ? 22.592  11.453  30.924  1.00 19.13  ? 4   LEU H CB  1 
ATOM   3289 C CG  . LEU C 1 4   ? 22.615  10.384  29.840  1.00 20.75  ? 4   LEU H CG  1 
ATOM   3290 C CD1 . LEU C 1 4   ? 21.657  9.254   30.195  1.00 23.29  ? 4   LEU H CD1 1 
ATOM   3291 C CD2 . LEU C 1 4   ? 22.261  10.974  28.502  1.00 20.16  ? 4   LEU H CD2 1 
ATOM   3292 N N   . VAL C 1 5   ? 22.880  14.842  31.690  1.00 18.28  ? 5   VAL H N   1 
ATOM   3293 C CA  . VAL C 1 5   ? 22.895  15.854  32.732  1.00 19.14  ? 5   VAL H CA  1 
ATOM   3294 C C   . VAL C 1 5   ? 21.454  16.274  33.013  1.00 16.72  ? 5   VAL H C   1 
ATOM   3295 O O   . VAL C 1 5   ? 20.743  16.755  32.140  1.00 16.24  ? 5   VAL H O   1 
ATOM   3296 C CB  . VAL C 1 5   ? 23.762  17.079  32.345  1.00 21.53  ? 5   VAL H CB  1 
ATOM   3297 C CG1 . VAL C 1 5   ? 23.819  18.128  33.454  1.00 22.37  ? 5   VAL H CG1 1 
ATOM   3298 C CG2 . VAL C 1 5   ? 25.172  16.676  31.965  1.00 24.08  ? 5   VAL H CG2 1 
ATOM   3299 N N   . GLN C 1 6   ? 21.054  16.109  34.261  1.00 18.66  ? 6   GLN H N   1 
ATOM   3300 C CA  . GLN C 1 6   ? 19.694  16.342  34.702  1.00 19.96  ? 6   GLN H CA  1 
ATOM   3301 C C   . GLN C 1 6   ? 19.582  17.696  35.363  1.00 19.86  ? 6   GLN H C   1 
ATOM   3302 O O   . GLN C 1 6   ? 20.567  18.263  35.797  1.00 20.90  ? 6   GLN H O   1 
ATOM   3303 C CB  . GLN C 1 6   ? 19.267  15.291  35.727  1.00 19.70  ? 6   GLN H CB  1 
ATOM   3304 C CG  . GLN C 1 6   ? 19.328  13.911  35.099  1.00 19.62  ? 6   GLN H CG  1 
ATOM   3305 C CD  . GLN C 1 6   ? 18.754  12.786  35.914  1.00 19.39  ? 6   GLN H CD  1 
ATOM   3306 O OE1 . GLN C 1 6   ? 19.303  11.690  35.918  1.00 17.81  ? 6   GLN H OE1 1 
ATOM   3307 N NE2 . GLN C 1 6   ? 17.595  13.010  36.509  1.00 19.81  ? 6   GLN H NE2 1 
ATOM   3308 N N   . SER C 1 7   ? 18.341  18.125  35.504  1.00 21.18  ? 7   SER H N   1 
ATOM   3309 C CA  . SER C 1 7   ? 18.034  19.359  36.181  1.00 24.23  ? 7   SER H CA  1 
ATOM   3310 C C   . SER C 1 7   ? 18.250  19.145  37.670  1.00 23.73  ? 7   SER H C   1 
ATOM   3311 O O   . SER C 1 7   ? 18.340  18.007  38.139  1.00 24.42  ? 7   SER H O   1 
ATOM   3312 C CB  . SER C 1 7   ? 16.616  19.822  35.854  1.00 24.91  ? 7   SER H CB  1 
ATOM   3313 O OG  . SER C 1 7   ? 15.677  18.757  35.972  1.00 22.97  ? 7   SER H OG  1 
ATOM   3314 N N   . GLY C 1 8   ? 18.323  20.274  38.382  1.00 22.31  ? 8   GLY H N   1 
ATOM   3315 C CA  . GLY C 1 8   ? 18.626  20.321  39.798  1.00 21.83  ? 8   GLY H CA  1 
ATOM   3316 C C   . GLY C 1 8   ? 17.452  19.870  40.659  1.00 22.63  ? 8   GLY H C   1 
ATOM   3317 O O   . GLY C 1 8   ? 16.316  19.724  40.195  1.00 22.00  ? 8   GLY H O   1 
ATOM   3318 N N   . SER C 1 9   ? 17.748  19.688  41.946  1.00 20.69  ? 9   SER H N   1 
ATOM   3319 C CA  . SER C 1 9   ? 16.747  19.208  42.854  1.00 22.55  ? 9   SER H CA  1 
ATOM   3320 C C   . SER C 1 9   ? 15.584  20.187  42.881  1.00 25.24  ? 9   SER H C   1 
ATOM   3321 O O   . SER C 1 9   ? 15.721  21.350  42.491  1.00 22.48  ? 9   SER H O   1 
ATOM   3322 C CB  . SER C 1 9   ? 17.291  18.981  44.220  1.00 24.63  ? 9   SER H CB  1 
ATOM   3323 O OG  . SER C 1 9   ? 17.702  20.190  44.797  1.00 27.24  ? 9   SER H OG  1 
ATOM   3324 N N   . GLU C 1 10  ? 14.451  19.649  43.343  1.00 25.02  ? 10  GLU H N   1 
ATOM   3325 C CA  . GLU C 1 10  ? 13.156  20.288  43.293  1.00 26.49  ? 10  GLU H CA  1 
ATOM   3326 C C   . GLU C 1 10  ? 12.521  20.072  44.659  1.00 25.74  ? 10  GLU H C   1 
ATOM   3327 O O   . GLU C 1 10  ? 12.679  19.007  45.261  1.00 28.04  ? 10  GLU H O   1 
ATOM   3328 C CB  . GLU C 1 10  ? 12.255  19.665  42.221  1.00 27.83  ? 10  GLU H CB  1 
ATOM   3329 C CG  . GLU C 1 10  ? 12.715  19.837  40.777  1.00 28.46  ? 10  GLU H CG  1 
ATOM   3330 C CD  . GLU C 1 10  ? 12.349  21.123  40.035  1.00 31.26  ? 10  GLU H CD  1 
ATOM   3331 O OE1 . GLU C 1 10  ? 11.574  21.965  40.585  1.00 35.09  ? 10  GLU H OE1 1 
ATOM   3332 O OE2 . GLU C 1 10  ? 12.849  21.296  38.899  1.00 26.69  ? 10  GLU H OE2 1 
ATOM   3333 N N   . LEU C 1 11  ? 11.863  21.118  45.149  1.00 26.17  ? 11  LEU H N   1 
ATOM   3334 C CA  . LEU C 1 11  ? 11.026  21.044  46.324  1.00 29.26  ? 11  LEU H CA  1 
ATOM   3335 C C   . LEU C 1 11  ? 9.631   21.537  45.926  1.00 30.68  ? 11  LEU H C   1 
ATOM   3336 O O   . LEU C 1 11  ? 9.501   22.616  45.366  1.00 32.70  ? 11  LEU H O   1 
ATOM   3337 C CB  . LEU C 1 11  ? 11.643  21.906  47.429  1.00 31.60  ? 11  LEU H CB  1 
ATOM   3338 C CG  . LEU C 1 11  ? 10.664  22.191  48.576  1.00 35.83  ? 11  LEU H CG  1 
ATOM   3339 C CD1 . LEU C 1 11  ? 10.456  20.934  49.424  1.00 31.27  ? 11  LEU H CD1 1 
ATOM   3340 C CD2 . LEU C 1 11  ? 11.099  23.395  49.415  1.00 33.38  ? 11  LEU H CD2 1 
ATOM   3341 N N   . LYS C 1 12  ? 8.588   20.734  46.148  1.00 32.33  ? 12  LYS H N   1 
ATOM   3342 C CA  . LYS C 1 12  ? 7.269   21.078  45.632  1.00 33.30  ? 12  LYS H CA  1 
ATOM   3343 C C   . LYS C 1 12  ? 6.227   20.718  46.671  1.00 33.15  ? 12  LYS H C   1 
ATOM   3344 O O   . LYS C 1 12  ? 6.423   19.775  47.426  1.00 33.76  ? 12  LYS H O   1 
ATOM   3345 C CB  . LYS C 1 12  ? 6.919   20.339  44.335  1.00 31.68  ? 12  LYS H CB  1 
ATOM   3346 C CG  . LYS C 1 12  ? 7.798   20.664  43.139  1.00 33.04  ? 12  LYS H CG  1 
ATOM   3347 C CD  . LYS C 1 12  ? 7.400   21.898  42.327  1.00 29.59  ? 12  LYS H CD  1 
ATOM   3348 C CE  . LYS C 1 12  ? 8.543   22.258  41.415  1.00 31.21  ? 12  LYS H CE  1 
ATOM   3349 N NZ  . LYS C 1 12  ? 8.164   23.147  40.301  1.00 30.11  ? 12  LYS H NZ  1 
ATOM   3350 N N   . LYS C 1 13  ? 5.132   21.479  46.664  1.00 34.41  ? 13  LYS H N   1 
ATOM   3351 C CA  . LYS C 1 13  ? 4.045   21.287  47.610  1.00 37.56  ? 13  LYS H CA  1 
ATOM   3352 C C   . LYS C 1 13  ? 3.158   20.154  47.114  1.00 31.99  ? 13  LYS H C   1 
ATOM   3353 O O   . LYS C 1 13  ? 3.118   19.902  45.917  1.00 30.74  ? 13  LYS H O   1 
ATOM   3354 C CB  . LYS C 1 13  ? 3.280   22.602  47.769  1.00 43.14  ? 13  LYS H CB  1 
ATOM   3355 C CG  . LYS C 1 13  ? 3.916   23.560  48.765  1.00 46.85  ? 13  LYS H CG  1 
ATOM   3356 C CD  . LYS C 1 13  ? 4.011   24.975  48.270  1.00 50.61  ? 13  LYS H CD  1 
ATOM   3357 C CE  . LYS C 1 13  ? 4.736   25.886  49.238  1.00 52.39  ? 13  LYS H CE  1 
ATOM   3358 N NZ  . LYS C 1 13  ? 5.348   27.037  48.524  1.00 57.56  ? 13  LYS H NZ  1 
ATOM   3359 N N   . PRO C 1 14  ? 2.472   19.402  48.002  1.00 28.25  ? 14  PRO H N   1 
ATOM   3360 C CA  . PRO C 1 14  ? 1.568   18.350  47.550  1.00 29.59  ? 14  PRO H CA  1 
ATOM   3361 C C   . PRO C 1 14  ? 0.533   18.961  46.606  1.00 31.87  ? 14  PRO H C   1 
ATOM   3362 O O   . PRO C 1 14  ? -0.033  20.003  46.906  1.00 35.96  ? 14  PRO H O   1 
ATOM   3363 C CB  . PRO C 1 14  ? 0.946   17.801  48.842  1.00 28.24  ? 14  PRO H CB  1 
ATOM   3364 C CG  . PRO C 1 14  ? 1.909   18.211  49.944  1.00 26.93  ? 14  PRO H CG  1 
ATOM   3365 C CD  . PRO C 1 14  ? 2.542   19.504  49.466  1.00 28.13  ? 14  PRO H CD  1 
ATOM   3366 N N   . GLY C 1 15  ? 0.343   18.343  45.441  1.00 30.86  ? 15  GLY H N   1 
ATOM   3367 C CA  . GLY C 1 15  ? -0.687  18.752  44.505  1.00 27.72  ? 15  GLY H CA  1 
ATOM   3368 C C   . GLY C 1 15  ? -0.067  19.453  43.308  1.00 28.27  ? 15  GLY H C   1 
ATOM   3369 O O   . GLY C 1 15  ? -0.652  19.495  42.226  1.00 32.08  ? 15  GLY H O   1 
ATOM   3370 N N   . ALA C 1 16  ? 1.151   19.964  43.505  1.00 24.52  ? 16  ALA H N   1 
ATOM   3371 C CA  . ALA C 1 16  ? 1.869   20.611  42.426  1.00 25.89  ? 16  ALA H CA  1 
ATOM   3372 C C   . ALA C 1 16  ? 2.349   19.587  41.399  1.00 24.51  ? 16  ALA H C   1 
ATOM   3373 O O   . ALA C 1 16  ? 2.190   18.385  41.566  1.00 25.50  ? 16  ALA H O   1 
ATOM   3374 C CB  . ALA C 1 16  ? 3.017   21.409  43.003  1.00 28.02  ? 16  ALA H CB  1 
ATOM   3375 N N   . SER C 1 17  ? 2.947   20.117  40.335  1.00 28.49  ? 17  SER H N   1 
ATOM   3376 C CA  . SER C 1 17  ? 3.549   19.366  39.252  1.00 28.83  ? 17  SER H CA  1 
ATOM   3377 C C   . SER C 1 17  ? 5.053   19.546  39.315  1.00 29.13  ? 17  SER H C   1 
ATOM   3378 O O   . SER C 1 17  ? 5.510   20.532  39.894  1.00 26.44  ? 17  SER H O   1 
ATOM   3379 C CB  . SER C 1 17  ? 3.035   19.833  37.927  1.00 28.20  ? 17  SER H CB  1 
ATOM   3380 O OG  . SER C 1 17  ? 1.906   19.057  37.575  1.00 39.55  ? 17  SER H OG  1 
ATOM   3381 N N   . VAL C 1 18  ? 5.791   18.611  38.693  1.00 25.16  ? 18  VAL H N   1 
ATOM   3382 C CA  . VAL C 1 18  ? 7.218   18.786  38.546  1.00 26.69  ? 18  VAL H CA  1 
ATOM   3383 C C   . VAL C 1 18  ? 7.637   18.292  37.169  1.00 27.03  ? 18  VAL H C   1 
ATOM   3384 O O   . VAL C 1 18  ? 7.097   17.314  36.687  1.00 28.03  ? 18  VAL H O   1 
ATOM   3385 C CB  . VAL C 1 18  ? 8.013   18.106  39.685  1.00 28.22  ? 18  VAL H CB  1 
ATOM   3386 C CG1 . VAL C 1 18  ? 7.942   16.591  39.650  1.00 28.63  ? 18  VAL H CG1 1 
ATOM   3387 C CG2 . VAL C 1 18  ? 9.464   18.556  39.689  1.00 27.83  ? 18  VAL H CG2 1 
ATOM   3388 N N   . LYS C 1 19  ? 8.633   18.967  36.582  1.00 25.96  ? 19  LYS H N   1 
ATOM   3389 C CA  . LYS C 1 19  ? 9.186   18.592  35.298  1.00 26.33  ? 19  LYS H CA  1 
ATOM   3390 C C   . LYS C 1 19  ? 10.694  18.438  35.433  1.00 26.03  ? 19  LYS H C   1 
ATOM   3391 O O   . LYS C 1 19  ? 11.413  19.417  35.607  1.00 30.15  ? 19  LYS H O   1 
ATOM   3392 C CB  . LYS C 1 19  ? 8.872   19.687  34.278  1.00 31.08  ? 19  LYS H CB  1 
ATOM   3393 C CG  . LYS C 1 19  ? 9.171   19.322  32.833  1.00 34.20  ? 19  LYS H CG  1 
ATOM   3394 C CD  . LYS C 1 19  ? 8.792   20.408  31.847  1.00 37.62  ? 19  LYS H CD  1 
ATOM   3395 C CE  . LYS C 1 19  ? 8.869   19.921  30.417  1.00 44.67  ? 19  LYS H CE  1 
ATOM   3396 N NZ  . LYS C 1 19  ? 8.332   20.911  29.455  1.00 48.30  ? 19  LYS H NZ  1 
ATOM   3397 N N   . VAL C 1 20  ? 11.182  17.211  35.302  1.00 22.74  ? 20  VAL H N   1 
ATOM   3398 C CA  . VAL C 1 20  ? 12.597  16.915  35.414  1.00 20.53  ? 20  VAL H CA  1 
ATOM   3399 C C   . VAL C 1 20  ? 13.165  16.809  34.011  1.00 20.38  ? 20  VAL H C   1 
ATOM   3400 O O   . VAL C 1 20  ? 12.561  16.159  33.163  1.00 20.72  ? 20  VAL H O   1 
ATOM   3401 C CB  . VAL C 1 20  ? 12.768  15.581  36.156  1.00 21.38  ? 20  VAL H CB  1 
ATOM   3402 C CG1 . VAL C 1 20  ? 14.208  15.079  36.108  1.00 23.47  ? 20  VAL H CG1 1 
ATOM   3403 C CG2 . VAL C 1 20  ? 12.256  15.674  37.580  1.00 21.01  ? 20  VAL H CG2 1 
ATOM   3404 N N   . SER C 1 21  ? 14.334  17.391  33.762  1.00 19.01  ? 21  SER H N   1 
ATOM   3405 C CA  . SER C 1 21  ? 14.919  17.231  32.451  1.00 20.62  ? 21  SER H CA  1 
ATOM   3406 C C   . SER C 1 21  ? 16.176  16.364  32.489  1.00 20.05  ? 21  SER H C   1 
ATOM   3407 O O   . SER C 1 21  ? 16.852  16.193  33.514  1.00 19.07  ? 21  SER H O   1 
ATOM   3408 C CB  . SER C 1 21  ? 15.206  18.556  31.875  1.00 25.42  ? 21  SER H CB  1 
ATOM   3409 O OG  . SER C 1 21  ? 16.062  19.233  32.754  1.00 33.67  ? 21  SER H OG  1 
ATOM   3410 N N   . CYS C 1 22  ? 16.509  15.872  31.297  1.00 19.74  ? 22  CYS H N   1 
ATOM   3411 C CA  . CYS C 1 22  ? 17.649  15.007  31.086  1.00 19.49  ? 22  CYS H CA  1 
ATOM   3412 C C   . CYS C 1 22  ? 18.246  15.368  29.738  1.00 19.94  ? 22  CYS H C   1 
ATOM   3413 O O   . CYS C 1 22  ? 17.689  15.011  28.713  1.00 20.30  ? 22  CYS H O   1 
ATOM   3414 C CB  . CYS C 1 22  ? 17.211  13.542  31.100  1.00 21.42  ? 22  CYS H CB  1 
ATOM   3415 S SG  . CYS C 1 22  ? 18.513  12.358  30.652  1.00 24.66  ? 22  CYS H SG  1 
ATOM   3416 N N   . LYS C 1 23  ? 19.411  16.014  29.745  1.00 21.23  ? 23  LYS H N   1 
ATOM   3417 C CA  . LYS C 1 23  ? 20.025  16.488  28.521  1.00 21.60  ? 23  LYS H CA  1 
ATOM   3418 C C   . LYS C 1 23  ? 21.216  15.611  28.168  1.00 19.47  ? 23  LYS H C   1 
ATOM   3419 O O   . LYS C 1 23  ? 22.125  15.412  28.955  1.00 21.34  ? 23  LYS H O   1 
ATOM   3420 C CB  . LYS C 1 23  ? 20.472  17.944  28.700  1.00 27.40  ? 23  LYS H CB  1 
ATOM   3421 C CG  . LYS C 1 23  ? 21.016  18.599  27.445  1.00 31.74  ? 23  LYS H CG  1 
ATOM   3422 C CD  . LYS C 1 23  ? 20.635  20.066  27.355  1.00 38.51  ? 23  LYS H CD  1 
ATOM   3423 C CE  . LYS C 1 23  ? 21.205  20.746  26.127  1.00 41.82  ? 23  LYS H CE  1 
ATOM   3424 N NZ  . LYS C 1 23  ? 22.682  20.658  26.155  1.00 45.23  ? 23  LYS H NZ  1 
ATOM   3425 N N   . ALA C 1 24  ? 21.183  15.073  26.968  1.00 19.85  ? 24  ALA H N   1 
ATOM   3426 C CA  . ALA C 1 24  ? 22.209  14.185  26.474  1.00 21.84  ? 24  ALA H CA  1 
ATOM   3427 C C   . ALA C 1 24  ? 23.155  14.969  25.573  1.00 20.43  ? 24  ALA H C   1 
ATOM   3428 O O   . ALA C 1 24  ? 22.724  15.869  24.868  1.00 22.57  ? 24  ALA H O   1 
ATOM   3429 C CB  . ALA C 1 24  ? 21.549  13.085  25.693  1.00 21.14  ? 24  ALA H CB  1 
ATOM   3430 N N   . SER C 1 25  ? 24.414  14.577  25.580  1.00 18.72  ? 25  SER H N   1 
ATOM   3431 C CA  . SER C 1 25  ? 25.395  15.099  24.648  1.00 21.39  ? 25  SER H CA  1 
ATOM   3432 C C   . SER C 1 25  ? 26.381  13.989  24.268  1.00 20.49  ? 25  SER H C   1 
ATOM   3433 O O   . SER C 1 25  ? 26.478  12.982  24.968  1.00 20.90  ? 25  SER H O   1 
ATOM   3434 C CB  . SER C 1 25  ? 26.084  16.273  25.265  1.00 20.48  ? 25  SER H CB  1 
ATOM   3435 O OG  . SER C 1 25  ? 26.584  15.930  26.548  1.00 24.11  ? 25  SER H OG  1 
ATOM   3436 N N   . GLY C 1 26  ? 27.081  14.194  23.146  1.00 19.34  ? 26  GLY H N   1 
ATOM   3437 C CA  . GLY C 1 26  ? 28.142  13.326  22.683  1.00 18.56  ? 26  GLY H CA  1 
ATOM   3438 C C   . GLY C 1 26  ? 27.695  12.148  21.829  1.00 18.97  ? 26  GLY H C   1 
ATOM   3439 O O   . GLY C 1 26  ? 28.505  11.265  21.580  1.00 24.72  ? 26  GLY H O   1 
ATOM   3440 N N   . TYR C 1 27  ? 26.437  12.091  21.395  1.00 20.40  ? 27  TYR H N   1 
ATOM   3441 C CA  . TYR C 1 27  ? 25.952  10.993  20.560  1.00 19.40  ? 27  TYR H CA  1 
ATOM   3442 C C   . TYR C 1 27  ? 24.700  11.496  19.861  1.00 22.42  ? 27  TYR H C   1 
ATOM   3443 O O   . TYR C 1 27  ? 24.167  12.500  20.296  1.00 20.79  ? 27  TYR H O   1 
ATOM   3444 C CB  . TYR C 1 27  ? 25.636  9.745   21.408  1.00 19.35  ? 27  TYR H CB  1 
ATOM   3445 C CG  . TYR C 1 27  ? 24.448  9.849   22.346  1.00 15.92  ? 27  TYR H CG  1 
ATOM   3446 C CD1 . TYR C 1 27  ? 24.585  10.262  23.655  1.00 15.46  ? 27  TYR H CD1 1 
ATOM   3447 C CD2 . TYR C 1 27  ? 23.178  9.491   21.942  1.00 17.56  ? 27  TYR H CD2 1 
ATOM   3448 C CE1 . TYR C 1 27  ? 23.504  10.369  24.521  1.00 14.77  ? 27  TYR H CE1 1 
ATOM   3449 C CE2 . TYR C 1 27  ? 22.091  9.552   22.803  1.00 15.99  ? 27  TYR H CE2 1 
ATOM   3450 C CZ  . TYR C 1 27  ? 22.239  9.994   24.098  1.00 15.22  ? 27  TYR H CZ  1 
ATOM   3451 O OH  . TYR C 1 27  ? 21.120  10.044  24.938  1.00 15.72  ? 27  TYR H OH  1 
ATOM   3452 N N   . THR C 1 28  ? 24.204  10.804  18.820  1.00 24.96  ? 28  THR H N   1 
ATOM   3453 C CA  . THR C 1 28  ? 22.943  11.204  18.211  1.00 26.83  ? 28  THR H CA  1 
ATOM   3454 C C   . THR C 1 28  ? 21.768  10.796  19.083  1.00 26.68  ? 28  THR H C   1 
ATOM   3455 O O   . THR C 1 28  ? 21.422  9.615   19.157  1.00 31.33  ? 28  THR H O   1 
ATOM   3456 C CB  . THR C 1 28  ? 22.718  10.583  16.837  1.00 29.03  ? 28  THR H CB  1 
ATOM   3457 O OG1 . THR C 1 28  ? 24.031  10.548  16.301  1.00 31.14  ? 28  THR H OG1 1 
ATOM   3458 C CG2 . THR C 1 28  ? 21.762  11.393  15.989  1.00 29.22  ? 28  THR H CG2 1 
ATOM   3459 N N   . PHE C 1 29  ? 21.143  11.807  19.687  1.00 22.17  ? 29  PHE H N   1 
ATOM   3460 C CA  . PHE C 1 29  ? 20.093  11.635  20.676  1.00 20.45  ? 29  PHE H CA  1 
ATOM   3461 C C   . PHE C 1 29  ? 19.023  10.638  20.218  1.00 19.23  ? 29  PHE H C   1 
ATOM   3462 O O   . PHE C 1 29  ? 18.566  9.824   21.004  1.00 16.33  ? 29  PHE H O   1 
ATOM   3463 C CB  . PHE C 1 29  ? 19.482  13.006  20.964  1.00 18.96  ? 29  PHE H CB  1 
ATOM   3464 C CG  . PHE C 1 29  ? 18.363  13.005  21.965  1.00 19.27  ? 29  PHE H CG  1 
ATOM   3465 C CD1 . PHE C 1 29  ? 18.607  12.707  23.292  1.00 18.41  ? 29  PHE H CD1 1 
ATOM   3466 C CD2 . PHE C 1 29  ? 17.075  13.329  21.575  1.00 18.99  ? 29  PHE H CD2 1 
ATOM   3467 C CE1 . PHE C 1 29  ? 17.577  12.717  24.210  1.00 17.71  ? 29  PHE H CE1 1 
ATOM   3468 C CE2 . PHE C 1 29  ? 16.041  13.314  22.494  1.00 18.48  ? 29  PHE H CE2 1 
ATOM   3469 C CZ  . PHE C 1 29  ? 16.297  12.999  23.802  1.00 18.60  ? 29  PHE H CZ  1 
ATOM   3470 N N   . THR C 1 30  ? 18.564  10.756  18.974  1.00 19.17  ? 30  THR H N   1 
ATOM   3471 C CA  . THR C 1 30  ? 17.361  10.055  18.545  1.00 20.87  ? 30  THR H CA  1 
ATOM   3472 C C   . THR C 1 30  ? 17.676  8.620   18.101  1.00 19.53  ? 30  THR H C   1 
ATOM   3473 O O   . THR C 1 30  ? 16.781  7.932   17.635  1.00 24.77  ? 30  THR H O   1 
ATOM   3474 C CB  . THR C 1 30  ? 16.681  10.831  17.410  1.00 21.82  ? 30  THR H CB  1 
ATOM   3475 O OG1 . THR C 1 30  ? 17.675  10.941  16.383  1.00 21.72  ? 30  THR H OG1 1 
ATOM   3476 C CG2 . THR C 1 30  ? 16.191  12.205  17.812  1.00 20.05  ? 30  THR H CG2 1 
ATOM   3477 N N   . ASN C 1 31  ? 18.945  8.190   18.195  1.00 18.39  ? 31  ASN H N   1 
ATOM   3478 C CA  . ASN C 1 31  ? 19.332  6.813   17.924  1.00 19.16  ? 31  ASN H CA  1 
ATOM   3479 C C   . ASN C 1 31  ? 19.196  5.884   19.134  1.00 18.17  ? 31  ASN H C   1 
ATOM   3480 O O   . ASN C 1 31  ? 19.309  4.677   18.942  1.00 20.06  ? 31  ASN H O   1 
ATOM   3481 C CB  . ASN C 1 31  ? 20.785  6.698   17.475  1.00 19.84  ? 31  ASN H CB  1 
ATOM   3482 C CG  . ASN C 1 31  ? 20.967  7.027   16.012  1.00 21.39  ? 31  ASN H CG  1 
ATOM   3483 O OD1 . ASN C 1 31  ? 20.016  7.077   15.245  1.00 25.63  ? 31  ASN H OD1 1 
ATOM   3484 N ND2 . ASN C 1 31  ? 22.183  7.332   15.628  1.00 23.40  ? 31  ASN H ND2 1 
ATOM   3485 N N   . TYR C 1 32  ? 19.006  6.419   20.346  1.00 16.33  ? 32  TYR H N   1 
ATOM   3486 C CA  . TYR C 1 32  ? 18.926  5.597   21.555  1.00 17.70  ? 32  TYR H CA  1 
ATOM   3487 C C   . TYR C 1 32  ? 17.713  5.996   22.378  1.00 16.14  ? 32  TYR H C   1 
ATOM   3488 O O   . TYR C 1 32  ? 17.448  7.172   22.552  1.00 13.62  ? 32  TYR H O   1 
ATOM   3489 C CB  . TYR C 1 32  ? 20.172  5.742   22.437  1.00 18.19  ? 32  TYR H CB  1 
ATOM   3490 C CG  . TYR C 1 32  ? 21.459  5.355   21.749  1.00 18.72  ? 32  TYR H CG  1 
ATOM   3491 C CD1 . TYR C 1 32  ? 22.074  6.216   20.854  1.00 17.92  ? 32  TYR H CD1 1 
ATOM   3492 C CD2 . TYR C 1 32  ? 22.027  4.100   21.937  1.00 20.35  ? 32  TYR H CD2 1 
ATOM   3493 C CE1 . TYR C 1 32  ? 23.217  5.845   20.174  1.00 18.29  ? 32  TYR H CE1 1 
ATOM   3494 C CE2 . TYR C 1 32  ? 23.198  3.724   21.296  1.00 20.42  ? 32  TYR H CE2 1 
ATOM   3495 C CZ  . TYR C 1 32  ? 23.790  4.607   20.414  1.00 21.05  ? 32  TYR H CZ  1 
ATOM   3496 O OH  . TYR C 1 32  ? 24.915  4.242   19.755  1.00 25.67  ? 32  TYR H OH  1 
ATOM   3497 N N   . GLY C 1 33  ? 16.913  5.003   22.781  1.00 16.76  ? 33  GLY H N   1 
ATOM   3498 C CA  . GLY C 1 33  ? 15.764  5.277   23.627  1.00 15.40  ? 33  GLY H CA  1 
ATOM   3499 C C   . GLY C 1 33  ? 16.260  5.713   24.999  1.00 16.53  ? 33  GLY H C   1 
ATOM   3500 O O   . GLY C 1 33  ? 17.415  5.493   25.317  1.00 17.79  ? 33  GLY H O   1 
ATOM   3501 N N   . MET C 1 34  ? 15.387  6.312   25.815  1.00 16.10  ? 34  MET H N   1 
ATOM   3502 C CA  . MET C 1 34  ? 15.743  6.761   27.142  1.00 16.80  ? 34  MET H CA  1 
ATOM   3503 C C   . MET C 1 34  ? 14.800  6.093   28.153  1.00 16.30  ? 34  MET H C   1 
ATOM   3504 O O   . MET C 1 34  ? 13.602  6.089   27.930  1.00 15.28  ? 34  MET H O   1 
ATOM   3505 C CB  . MET C 1 34  ? 15.612  8.285   27.206  1.00 17.34  ? 34  MET H CB  1 
ATOM   3506 C CG  . MET C 1 34  ? 16.174  8.888   28.451  1.00 18.70  ? 34  MET H CG  1 
ATOM   3507 S SD  . MET C 1 34  ? 18.006  8.689   28.561  1.00 21.96  ? 34  MET H SD  1 
ATOM   3508 C CE  . MET C 1 34  ? 18.575  9.771   27.256  1.00 19.63  ? 34  MET H CE  1 
ATOM   3509 N N   . ASN C 1 35  ? 15.356  5.609   29.285  1.00 14.69  ? 35  ASN H N   1 
ATOM   3510 C CA  . ASN C 1 35  ? 14.587  5.061   30.394  1.00 13.86  ? 35  ASN H CA  1 
ATOM   3511 C C   . ASN C 1 35  ? 14.528  6.041   31.562  1.00 12.90  ? 35  ASN H C   1 
ATOM   3512 O O   . ASN C 1 35  ? 15.373  6.912   31.727  1.00 13.29  ? 35  ASN H O   1 
ATOM   3513 C CB  . ASN C 1 35  ? 15.181  3.737   30.887  1.00 13.99  ? 35  ASN H CB  1 
ATOM   3514 C CG  . ASN C 1 35  ? 15.358  2.740   29.769  1.00 14.44  ? 35  ASN H CG  1 
ATOM   3515 O OD1 . ASN C 1 35  ? 14.469  1.921   29.542  1.00 14.45  ? 35  ASN H OD1 1 
ATOM   3516 N ND2 . ASN C 1 35  ? 16.430  2.873   28.999  1.00 12.98  ? 35  ASN H ND2 1 
ATOM   3517 N N   . TRP C 1 36  ? 13.492  5.901   32.364  1.00 13.34  ? 36  TRP H N   1 
ATOM   3518 C CA  . TRP C 1 36  ? 13.345  6.608   33.618  1.00 13.67  ? 36  TRP H CA  1 
ATOM   3519 C C   . TRP C 1 36  ? 13.275  5.607   34.754  1.00 13.36  ? 36  TRP H C   1 
ATOM   3520 O O   . TRP C 1 36  ? 12.579  4.582   34.650  1.00 13.35  ? 36  TRP H O   1 
ATOM   3521 C CB  . TRP C 1 36  ? 12.097  7.483   33.571  1.00 15.08  ? 36  TRP H CB  1 
ATOM   3522 C CG  . TRP C 1 36  ? 12.265  8.660   32.658  1.00 19.19  ? 36  TRP H CG  1 
ATOM   3523 C CD1 . TRP C 1 36  ? 11.750  8.814   31.402  1.00 21.41  ? 36  TRP H CD1 1 
ATOM   3524 C CD2 . TRP C 1 36  ? 12.991  9.872   32.936  1.00 18.25  ? 36  TRP H CD2 1 
ATOM   3525 N NE1 . TRP C 1 36  ? 12.085  10.037  30.899  1.00 18.62  ? 36  TRP H NE1 1 
ATOM   3526 C CE2 . TRP C 1 36  ? 12.849  10.706  31.816  1.00 19.82  ? 36  TRP H CE2 1 
ATOM   3527 C CE3 . TRP C 1 36  ? 13.708  10.347  34.034  1.00 19.13  ? 36  TRP H CE3 1 
ATOM   3528 C CZ2 . TRP C 1 36  ? 13.441  11.970  31.743  1.00 18.60  ? 36  TRP H CZ2 1 
ATOM   3529 C CZ3 . TRP C 1 36  ? 14.278  11.599  33.972  1.00 19.34  ? 36  TRP H CZ3 1 
ATOM   3530 C CH2 . TRP C 1 36  ? 14.121  12.410  32.849  1.00 18.81  ? 36  TRP H CH2 1 
ATOM   3531 N N   . VAL C 1 37  ? 13.974  5.937   35.847  1.00 13.77  ? 37  VAL H N   1 
ATOM   3532 C CA  . VAL C 1 37  ? 14.050  5.077   37.011  1.00 14.46  ? 37  VAL H CA  1 
ATOM   3533 C C   . VAL C 1 37  ? 13.859  5.889   38.291  1.00 15.55  ? 37  VAL H C   1 
ATOM   3534 O O   . VAL C 1 37  ? 14.545  6.881   38.496  1.00 15.99  ? 37  VAL H O   1 
ATOM   3535 C CB  . VAL C 1 37  ? 15.425  4.387   37.032  1.00 14.18  ? 37  VAL H CB  1 
ATOM   3536 C CG1 . VAL C 1 37  ? 15.546  3.509   38.255  1.00 13.91  ? 37  VAL H CG1 1 
ATOM   3537 C CG2 . VAL C 1 37  ? 15.705  3.637   35.736  1.00 13.97  ? 37  VAL H CG2 1 
ATOM   3538 N N   . ARG C 1 38  ? 13.058  5.362   39.212  1.00 16.20  ? 38  ARG H N   1 
ATOM   3539 C CA  . ARG C 1 38  ? 12.806  5.992   40.499  1.00 19.27  ? 38  ARG H CA  1 
ATOM   3540 C C   . ARG C 1 38  ? 13.545  5.231   41.600  1.00 19.17  ? 38  ARG H C   1 
ATOM   3541 O O   . ARG C 1 38  ? 13.489  4.010   41.629  1.00 19.20  ? 38  ARG H O   1 
ATOM   3542 C CB  . ARG C 1 38  ? 11.298  5.982   40.794  1.00 19.70  ? 38  ARG H CB  1 
ATOM   3543 C CG  . ARG C 1 38  ? 10.911  6.590   42.135  1.00 23.59  ? 38  ARG H CG  1 
ATOM   3544 C CD  . ARG C 1 38  ? 9.398   6.650   42.411  1.00 26.68  ? 38  ARG H CD  1 
ATOM   3545 N NE  . ARG C 1 38  ? 8.827   5.344   42.719  1.00 30.86  ? 38  ARG H NE  1 
ATOM   3546 C CZ  . ARG C 1 38  ? 7.515   5.043   42.735  1.00 37.23  ? 38  ARG H CZ  1 
ATOM   3547 N NH1 . ARG C 1 38  ? 6.587   5.983   42.646  1.00 34.80  ? 38  ARG H NH1 1 
ATOM   3548 N NH2 . ARG C 1 38  ? 7.112   3.782   42.838  1.00 36.65  ? 38  ARG H NH2 1 
ATOM   3549 N N   . GLN C 1 39  ? 14.142  5.967   42.554  1.00 18.11  ? 39  GLN H N   1 
ATOM   3550 C CA  . GLN C 1 39  ? 14.661  5.382   43.779  1.00 18.49  ? 39  GLN H CA  1 
ATOM   3551 C C   . GLN C 1 39  ? 14.175  6.220   44.955  1.00 20.86  ? 39  GLN H C   1 
ATOM   3552 O O   . GLN C 1 39  ? 14.643  7.353   45.127  1.00 17.77  ? 39  GLN H O   1 
ATOM   3553 C CB  . GLN C 1 39  ? 16.192  5.375   43.753  1.00 19.20  ? 39  GLN H CB  1 
ATOM   3554 C CG  . GLN C 1 39  ? 16.859  4.791   44.989  1.00 19.17  ? 39  GLN H CG  1 
ATOM   3555 C CD  . GLN C 1 39  ? 18.217  4.254   44.574  1.00 19.14  ? 39  GLN H CD  1 
ATOM   3556 O OE1 . GLN C 1 39  ? 19.034  4.956   43.968  1.00 16.89  ? 39  GLN H OE1 1 
ATOM   3557 N NE2 . GLN C 1 39  ? 18.433  2.976   44.833  1.00 17.29  ? 39  GLN H NE2 1 
ATOM   3558 N N   . ALA C 1 40  ? 13.228  5.651   45.725  1.00 19.77  ? 40  ALA H N   1 
ATOM   3559 C CA  . ALA C 1 40  ? 12.798  6.224   46.974  1.00 21.83  ? 40  ALA H CA  1 
ATOM   3560 C C   . ALA C 1 40  ? 13.925  6.084   47.999  1.00 26.00  ? 40  ALA H C   1 
ATOM   3561 O O   . ALA C 1 40  ? 14.775  5.189   47.886  1.00 25.33  ? 40  ALA H O   1 
ATOM   3562 C CB  . ALA C 1 40  ? 11.519  5.556   47.453  1.00 21.40  ? 40  ALA H CB  1 
ATOM   3563 N N   . PRO C 1 41  ? 13.936  6.948   49.046  1.00 29.14  ? 41  PRO H N   1 
ATOM   3564 C CA  . PRO C 1 41  ? 15.036  6.971   50.020  1.00 32.48  ? 41  PRO H CA  1 
ATOM   3565 C C   . PRO C 1 41  ? 15.260  5.600   50.660  1.00 27.75  ? 41  PRO H C   1 
ATOM   3566 O O   . PRO C 1 41  ? 14.312  4.982   51.127  1.00 26.88  ? 41  PRO H O   1 
ATOM   3567 C CB  . PRO C 1 41  ? 14.574  8.013   51.059  1.00 31.90  ? 41  PRO H CB  1 
ATOM   3568 C CG  . PRO C 1 41  ? 13.626  8.914   50.278  1.00 33.25  ? 41  PRO H CG  1 
ATOM   3569 C CD  . PRO C 1 41  ? 12.899  7.963   49.340  1.00 31.11  ? 41  PRO H CD  1 
ATOM   3570 N N   . GLY C 1 42  ? 16.508  5.128   50.570  1.00 26.92  ? 42  GLY H N   1 
ATOM   3571 C CA  . GLY C 1 42  ? 16.945  3.799   50.987  1.00 24.92  ? 42  GLY H CA  1 
ATOM   3572 C C   . GLY C 1 42  ? 16.214  2.618   50.340  1.00 25.13  ? 42  GLY H C   1 
ATOM   3573 O O   . GLY C 1 42  ? 16.273  1.524   50.878  1.00 26.65  ? 42  GLY H O   1 
ATOM   3574 N N   . GLN C 1 43  ? 15.547  2.801   49.194  1.00 24.11  ? 43  GLN H N   1 
ATOM   3575 C CA  . GLN C 1 43  ? 14.838  1.697   48.559  1.00 24.65  ? 43  GLN H CA  1 
ATOM   3576 C C   . GLN C 1 43  ? 15.574  1.329   47.286  1.00 23.00  ? 43  GLN H C   1 
ATOM   3577 O O   . GLN C 1 43  ? 16.572  1.948   46.956  1.00 22.11  ? 43  GLN H O   1 
ATOM   3578 C CB  . GLN C 1 43  ? 13.394  2.084   48.239  1.00 27.78  ? 43  GLN H CB  1 
ATOM   3579 C CG  . GLN C 1 43  ? 12.562  2.354   49.480  1.00 31.10  ? 43  GLN H CG  1 
ATOM   3580 C CD  . GLN C 1 43  ? 12.602  1.163   50.401  1.00 32.54  ? 43  GLN H CD  1 
ATOM   3581 O OE1 . GLN C 1 43  ? 12.450  0.018   49.987  1.00 41.29  ? 43  GLN H OE1 1 
ATOM   3582 N NE2 . GLN C 1 43  ? 12.885  1.407   51.663  1.00 35.30  ? 43  GLN H NE2 1 
ATOM   3583 N N   . GLY C 1 44  ? 15.042  0.363   46.540  1.00 22.58  ? 44  GLY H N   1 
ATOM   3584 C CA  . GLY C 1 44  ? 15.714  -0.102  45.340  1.00 20.34  ? 44  GLY H CA  1 
ATOM   3585 C C   . GLY C 1 44  ? 15.368  0.730   44.107  1.00 19.32  ? 44  GLY H C   1 
ATOM   3586 O O   . GLY C 1 44  ? 14.528  1.620   44.171  1.00 17.55  ? 44  GLY H O   1 
ATOM   3587 N N   . LEU C 1 45  ? 16.071  0.429   43.004  1.00 16.87  ? 45  LEU H N   1 
ATOM   3588 C CA  . LEU C 1 45  ? 15.775  0.962   41.693  1.00 18.11  ? 45  LEU H CA  1 
ATOM   3589 C C   . LEU C 1 45  ? 14.499  0.347   41.112  1.00 19.11  ? 45  LEU H C   1 
ATOM   3590 O O   . LEU C 1 45  ? 14.300  -0.863  41.191  1.00 16.38  ? 45  LEU H O   1 
ATOM   3591 C CB  . LEU C 1 45  ? 16.968  0.622   40.800  1.00 18.47  ? 45  LEU H CB  1 
ATOM   3592 C CG  . LEU C 1 45  ? 18.299  1.227   41.232  1.00 17.53  ? 45  LEU H CG  1 
ATOM   3593 C CD1 . LEU C 1 45  ? 19.455  0.628   40.431  1.00 16.89  ? 45  LEU H CD1 1 
ATOM   3594 C CD2 . LEU C 1 45  ? 18.239  2.735   41.092  1.00 18.13  ? 45  LEU H CD2 1 
ATOM   3595 N N   . GLU C 1 46  ? 13.620  1.197   40.560  1.00 20.35  ? 46  GLU H N   1 
ATOM   3596 C CA  . GLU C 1 46  ? 12.416  0.730   39.892  1.00 20.91  ? 46  GLU H CA  1 
ATOM   3597 C C   . GLU C 1 46  ? 12.293  1.429   38.545  1.00 18.56  ? 46  GLU H C   1 
ATOM   3598 O O   . GLU C 1 46  ? 12.215  2.652   38.478  1.00 15.38  ? 46  GLU H O   1 
ATOM   3599 C CB  . GLU C 1 46  ? 11.099  1.104   40.582  1.00 24.05  ? 46  GLU H CB  1 
ATOM   3600 C CG  . GLU C 1 46  ? 11.052  1.043   42.093  1.00 26.69  ? 46  GLU H CG  1 
ATOM   3601 C CD  . GLU C 1 46  ? 9.919   1.923   42.628  1.00 30.85  ? 46  GLU H CD  1 
ATOM   3602 O OE1 . GLU C 1 46  ? 8.743   1.600   42.320  1.00 29.51  ? 46  GLU H OE1 1 
ATOM   3603 O OE2 . GLU C 1 46  ? 10.214  2.997   43.267  1.00 27.89  ? 46  GLU H OE2 1 
ATOM   3604 N N   . TRP C 1 47  ? 12.195  0.634   37.492  1.00 16.71  ? 47  TRP H N   1 
ATOM   3605 C CA  . TRP C 1 47  ? 11.991  1.157   36.161  1.00 15.91  ? 47  TRP H CA  1 
ATOM   3606 C C   . TRP C 1 47  ? 10.587  1.731   36.020  1.00 16.32  ? 47  TRP H C   1 
ATOM   3607 O O   . TRP C 1 47  ? 9.586   1.090   36.381  1.00 16.35  ? 47  TRP H O   1 
ATOM   3608 C CB  . TRP C 1 47  ? 12.248  0.036   35.170  1.00 16.11  ? 47  TRP H CB  1 
ATOM   3609 C CG  . TRP C 1 47  ? 12.157  0.412   33.730  1.00 15.26  ? 47  TRP H CG  1 
ATOM   3610 C CD1 . TRP C 1 47  ? 13.087  1.043   32.954  1.00 15.45  ? 47  TRP H CD1 1 
ATOM   3611 C CD2 . TRP C 1 47  ? 11.094  0.020   32.866  1.00 15.51  ? 47  TRP H CD2 1 
ATOM   3612 N NE1 . TRP C 1 47  ? 12.630  1.145   31.672  1.00 15.37  ? 47  TRP H NE1 1 
ATOM   3613 C CE2 . TRP C 1 47  ? 11.408  0.521   31.588  1.00 15.74  ? 47  TRP H CE2 1 
ATOM   3614 C CE3 . TRP C 1 47  ? 9.888   -0.662  33.074  1.00 16.03  ? 47  TRP H CE3 1 
ATOM   3615 C CZ2 . TRP C 1 47  ? 10.569  0.315   30.496  1.00 15.70  ? 47  TRP H CZ2 1 
ATOM   3616 C CZ3 . TRP C 1 47  ? 9.035   -0.812  32.005  1.00 16.60  ? 47  TRP H CZ3 1 
ATOM   3617 C CH2 . TRP C 1 47  ? 9.383   -0.336  30.732  1.00 15.76  ? 47  TRP H CH2 1 
ATOM   3618 N N   . MET C 1 48  ? 10.540  2.974   35.526  1.00 15.27  ? 48  MET H N   1 
ATOM   3619 C CA  . MET C 1 48  ? 9.295   3.710   35.397  1.00 14.90  ? 48  MET H CA  1 
ATOM   3620 C C   . MET C 1 48  ? 8.764   3.552   33.977  1.00 13.45  ? 48  MET H C   1 
ATOM   3621 O O   . MET C 1 48  ? 7.578   3.659   33.756  1.00 13.46  ? 48  MET H O   1 
ATOM   3622 C CB  . MET C 1 48  ? 9.509   5.198   35.654  1.00 14.81  ? 48  MET H CB  1 
ATOM   3623 C CG  . MET C 1 48  ? 9.910   5.495   37.062  1.00 16.73  ? 48  MET H CG  1 
ATOM   3624 S SD  . MET C 1 48  ? 10.367  7.235   37.245  1.00 18.26  ? 48  MET H SD  1 
ATOM   3625 C CE  . MET C 1 48  ? 8.749   7.998   37.190  1.00 17.37  ? 48  MET H CE  1 
ATOM   3626 N N   . GLY C 1 49  ? 9.646   3.322   33.020  1.00 12.60  ? 49  GLY H N   1 
ATOM   3627 C CA  . GLY C 1 49  ? 9.255   3.289   31.622  1.00 12.79  ? 49  GLY H CA  1 
ATOM   3628 C C   . GLY C 1 49  ? 10.373  3.755   30.695  1.00 13.10  ? 49  GLY H C   1 
ATOM   3629 O O   . GLY C 1 49  ? 11.477  4.078   31.154  1.00 14.11  ? 49  GLY H O   1 
ATOM   3630 N N   . TRP C 1 50  ? 10.027  3.839   29.411  1.00 13.00  ? 50  TRP H N   1 
ATOM   3631 C CA  . TRP C 1 50  ? 10.948  4.130   28.319  1.00 14.45  ? 50  TRP H CA  1 
ATOM   3632 C C   . TRP C 1 50  ? 10.286  5.079   27.320  1.00 14.58  ? 50  TRP H C   1 
ATOM   3633 O O   . TRP C 1 50  ? 9.064   5.083   27.225  1.00 15.79  ? 50  TRP H O   1 
ATOM   3634 C CB  . TRP C 1 50  ? 11.286  2.810   27.650  1.00 14.08  ? 50  TRP H CB  1 
ATOM   3635 C CG  . TRP C 1 50  ? 12.113  2.838   26.405  1.00 14.44  ? 50  TRP H CG  1 
ATOM   3636 C CD1 . TRP C 1 50  ? 13.467  2.718   26.319  1.00 14.37  ? 50  TRP H CD1 1 
ATOM   3637 C CD2 . TRP C 1 50  ? 11.635  2.778   25.056  1.00 14.61  ? 50  TRP H CD2 1 
ATOM   3638 N NE1 . TRP C 1 50  ? 13.869  2.699   25.010  1.00 13.85  ? 50  TRP H NE1 1 
ATOM   3639 C CE2 . TRP C 1 50  ? 12.763  2.701   24.220  1.00 13.92  ? 50  TRP H CE2 1 
ATOM   3640 C CE3 . TRP C 1 50  ? 10.359  2.740   24.484  1.00 15.15  ? 50  TRP H CE3 1 
ATOM   3641 C CZ2 . TRP C 1 50  ? 12.656  2.590   22.843  1.00 15.65  ? 50  TRP H CZ2 1 
ATOM   3642 C CZ3 . TRP C 1 50  ? 10.254  2.650   23.117  1.00 14.58  ? 50  TRP H CZ3 1 
ATOM   3643 C CH2 . TRP C 1 50  ? 11.386  2.566   22.317  1.00 15.52  ? 50  TRP H CH2 1 
ATOM   3644 N N   . ILE C 1 51  ? 11.088  5.836   26.562  1.00 14.57  ? 51  ILE H N   1 
ATOM   3645 C CA  . ILE C 1 51  ? 10.558  6.683   25.508  1.00 14.75  ? 51  ILE H CA  1 
ATOM   3646 C C   . ILE C 1 51  ? 11.446  6.530   24.286  1.00 15.88  ? 51  ILE H C   1 
ATOM   3647 O O   . ILE C 1 51  ? 12.686  6.560   24.375  1.00 15.28  ? 51  ILE H O   1 
ATOM   3648 C CB  . ILE C 1 51  ? 10.390  8.160   25.929  1.00 15.82  ? 51  ILE H CB  1 
ATOM   3649 C CG1 . ILE C 1 51  ? 9.599   8.954   24.878  1.00 15.69  ? 51  ILE H CG1 1 
ATOM   3650 C CG2 . ILE C 1 51  ? 11.725  8.827   26.243  1.00 16.01  ? 51  ILE H CG2 1 
ATOM   3651 C CD1 . ILE C 1 51  ? 9.344   10.393  25.239  1.00 14.39  ? 51  ILE H CD1 1 
ATOM   3652 N N   . ASN C 1 52  ? 10.753  6.334   23.155  1.00 15.96  ? 52  ASN H N   1 
ATOM   3653 C CA  . ASN C 1 52  ? 11.321  6.366   21.824  1.00 17.51  ? 52  ASN H CA  1 
ATOM   3654 C C   . ASN C 1 52  ? 11.717  7.795   21.472  1.00 20.54  ? 52  ASN H C   1 
ATOM   3655 O O   . ASN C 1 52  ? 10.857  8.682   21.367  1.00 20.08  ? 52  ASN H O   1 
ATOM   3656 C CB  . ASN C 1 52  ? 10.320  5.800   20.815  1.00 18.55  ? 52  ASN H CB  1 
ATOM   3657 C CG  . ASN C 1 52  ? 10.931  5.570   19.454  1.00 19.29  ? 52  ASN H CG  1 
ATOM   3658 O OD1 . ASN C 1 52  ? 11.710  6.395   18.975  1.00 19.02  ? 52  ASN H OD1 1 
ATOM   3659 N ND2 . ASN C 1 52  ? 10.599  4.446   18.838  1.00 20.14  ? 52  ASN H ND2 1 
ATOM   3660 N N   . THR C 1 53  ? 13.040  8.016   21.372  1.00 21.58  ? 53  THR H N   1 
ATOM   3661 C CA  . THR C 1 53  ? 13.577  9.362   21.247  1.00 23.32  ? 53  THR H CA  1 
ATOM   3662 C C   . THR C 1 53  ? 13.452  9.865   19.812  1.00 23.48  ? 53  THR H C   1 
ATOM   3663 O O   . THR C 1 53  ? 13.737  11.029  19.560  1.00 23.90  ? 53  THR H O   1 
ATOM   3664 C CB  . THR C 1 53  ? 15.035  9.457   21.721  1.00 22.35  ? 53  THR H CB  1 
ATOM   3665 O OG1 . THR C 1 53  ? 15.811  8.433   21.096  1.00 24.33  ? 53  THR H OG1 1 
ATOM   3666 C CG2 . THR C 1 53  ? 15.157  9.327   23.223  1.00 20.88  ? 53  THR H CG2 1 
ATOM   3667 N N   . TYR C 1 54  ? 13.055  8.997   18.875  1.00 23.56  ? 54  TYR H N   1 
ATOM   3668 C CA  . TYR C 1 54  ? 12.848  9.423   17.505  1.00 22.13  ? 54  TYR H CA  1 
ATOM   3669 C C   . TYR C 1 54  ? 11.377  9.728   17.293  1.00 23.69  ? 54  TYR H C   1 
ATOM   3670 O O   . TYR C 1 54  ? 11.083  10.733  16.673  1.00 23.85  ? 54  TYR H O   1 
ATOM   3671 C CB  . TYR C 1 54  ? 13.348  8.414   16.475  1.00 25.09  ? 54  TYR H CB  1 
ATOM   3672 C CG  . TYR C 1 54  ? 13.280  8.928   15.056  1.00 27.03  ? 54  TYR H CG  1 
ATOM   3673 C CD1 . TYR C 1 54  ? 12.082  8.966   14.358  1.00 27.84  ? 54  TYR H CD1 1 
ATOM   3674 C CD2 . TYR C 1 54  ? 14.415  9.422   14.430  1.00 30.61  ? 54  TYR H CD2 1 
ATOM   3675 C CE1 . TYR C 1 54  ? 12.022  9.452   13.060  1.00 32.01  ? 54  TYR H CE1 1 
ATOM   3676 C CE2 . TYR C 1 54  ? 14.369  9.937   13.140  1.00 34.51  ? 54  TYR H CE2 1 
ATOM   3677 C CZ  . TYR C 1 54  ? 13.165  9.958   12.460  1.00 33.81  ? 54  TYR H CZ  1 
ATOM   3678 O OH  . TYR C 1 54  ? 13.129  10.441  11.187  1.00 42.29  ? 54  TYR H OH  1 
ATOM   3679 N N   . THR C 1 55  ? 10.466  8.843   17.744  1.00 23.37  ? 55  THR H N   1 
ATOM   3680 C CA  . THR C 1 55  ? 9.053   9.029   17.458  1.00 21.44  ? 55  THR H CA  1 
ATOM   3681 C C   . THR C 1 55  ? 8.342   9.765   18.597  1.00 23.54  ? 55  THR H C   1 
ATOM   3682 O O   . THR C 1 55  ? 7.262   10.264  18.386  1.00 24.00  ? 55  THR H O   1 
ATOM   3683 C CB  . THR C 1 55  ? 8.322   7.713   17.179  1.00 22.85  ? 55  THR H CB  1 
ATOM   3684 O OG1 . THR C 1 55  ? 8.249   6.969   18.391  1.00 23.04  ? 55  THR H OG1 1 
ATOM   3685 C CG2 . THR C 1 55  ? 8.930   6.878   16.071  1.00 23.45  ? 55  THR H CG2 1 
ATOM   3686 N N   . GLY C 1 56  ? 8.914   9.821   19.813  1.00 26.01  ? 56  GLY H N   1 
ATOM   3687 C CA  . GLY C 1 56  ? 8.247   10.422  20.962  1.00 23.85  ? 56  GLY H CA  1 
ATOM   3688 C C   . GLY C 1 56  ? 7.318   9.472   21.719  1.00 23.71  ? 56  GLY H C   1 
ATOM   3689 O O   . GLY C 1 56  ? 6.738   9.856   22.721  1.00 23.11  ? 56  GLY H O   1 
ATOM   3690 N N   . GLN C 1 57  ? 7.231   8.213   21.281  1.00 29.53  ? 57  GLN H N   1 
ATOM   3691 C CA  . GLN C 1 57  ? 6.265   7.250   21.806  1.00 31.64  ? 57  GLN H CA  1 
ATOM   3692 C C   . GLN C 1 57  ? 6.762   6.679   23.139  1.00 28.07  ? 57  GLN H C   1 
ATOM   3693 O O   . GLN C 1 57  ? 7.846   6.079   23.210  1.00 24.31  ? 57  GLN H O   1 
ATOM   3694 C CB  . GLN C 1 57  ? 6.014   6.150   20.775  1.00 35.30  ? 57  GLN H CB  1 
ATOM   3695 C CG  . GLN C 1 57  ? 5.679   4.778   21.362  1.00 45.48  ? 57  GLN H CG  1 
ATOM   3696 C CD  . GLN C 1 57  ? 4.191   4.560   21.513  1.00 49.08  ? 57  GLN H CD  1 
ATOM   3697 O OE1 . GLN C 1 57  ? 3.517   4.192   20.555  1.00 53.36  ? 57  GLN H OE1 1 
ATOM   3698 N NE2 . GLN C 1 57  ? 3.670   4.781   22.713  1.00 52.51  ? 57  GLN H NE2 1 
ATOM   3699 N N   . PRO C 1 58  ? 5.991   6.909   24.230  1.00 26.37  ? 58  PRO H N   1 
ATOM   3700 C CA  . PRO C 1 58  ? 6.305   6.389   25.558  1.00 25.43  ? 58  PRO H CA  1 
ATOM   3701 C C   . PRO C 1 58  ? 5.642   5.056   25.903  1.00 26.53  ? 58  PRO H C   1 
ATOM   3702 O O   . PRO C 1 58  ? 4.582   4.728   25.386  1.00 29.18  ? 58  PRO H O   1 
ATOM   3703 C CB  . PRO C 1 58  ? 5.734   7.503   26.439  1.00 26.75  ? 58  PRO H CB  1 
ATOM   3704 C CG  . PRO C 1 58  ? 4.465   7.940   25.720  1.00 27.84  ? 58  PRO H CG  1 
ATOM   3705 C CD  . PRO C 1 58  ? 4.796   7.776   24.251  1.00 27.69  ? 58  PRO H CD  1 
ATOM   3706 N N   . ILE C 1 59  ? 6.337   4.281   26.741  1.00 26.01  ? 59  ILE H N   1 
ATOM   3707 C CA  . ILE C 1 59  ? 5.897   3.018   27.320  1.00 23.69  ? 59  ILE H CA  1 
ATOM   3708 C C   . ILE C 1 59  ? 6.064   3.130   28.840  1.00 21.72  ? 59  ILE H C   1 
ATOM   3709 O O   . ILE C 1 59  ? 7.181   3.350   29.348  1.00 20.23  ? 59  ILE H O   1 
ATOM   3710 C CB  . ILE C 1 59  ? 6.773   1.857   26.793  1.00 28.15  ? 59  ILE H CB  1 
ATOM   3711 C CG1 . ILE C 1 59  ? 6.837   1.787   25.263  1.00 29.25  ? 59  ILE H CG1 1 
ATOM   3712 C CG2 . ILE C 1 59  ? 6.318   0.528   27.398  1.00 30.75  ? 59  ILE H CG2 1 
ATOM   3713 C CD1 . ILE C 1 59  ? 5.529   1.442   24.620  1.00 28.48  ? 59  ILE H CD1 1 
ATOM   3714 N N   . TYR C 1 60  ? 4.980   2.942   29.567  1.00 18.65  ? 60  TYR H N   1 
ATOM   3715 C CA  . TYR C 1 60  ? 4.986   3.156   30.996  1.00 21.86  ? 60  TYR H CA  1 
ATOM   3716 C C   . TYR C 1 60  ? 4.971   1.810   31.694  1.00 23.72  ? 60  TYR H C   1 
ATOM   3717 O O   . TYR C 1 60  ? 4.263   0.909   31.250  1.00 22.46  ? 60  TYR H O   1 
ATOM   3718 C CB  . TYR C 1 60  ? 3.777   3.991   31.412  1.00 21.34  ? 60  TYR H CB  1 
ATOM   3719 C CG  . TYR C 1 60  ? 3.833   5.376   30.830  1.00 22.93  ? 60  TYR H CG  1 
ATOM   3720 C CD1 . TYR C 1 60  ? 4.759   6.299   31.294  1.00 22.77  ? 60  TYR H CD1 1 
ATOM   3721 C CD2 . TYR C 1 60  ? 3.014   5.742   29.772  1.00 23.38  ? 60  TYR H CD2 1 
ATOM   3722 C CE1 . TYR C 1 60  ? 4.834   7.572   30.755  1.00 22.10  ? 60  TYR H CE1 1 
ATOM   3723 C CE2 . TYR C 1 60  ? 3.079   7.011   29.218  1.00 23.97  ? 60  TYR H CE2 1 
ATOM   3724 C CZ  . TYR C 1 60  ? 4.004   7.917   29.706  1.00 21.53  ? 60  TYR H CZ  1 
ATOM   3725 O OH  . TYR C 1 60  ? 4.052   9.153   29.166  1.00 21.41  ? 60  TYR H OH  1 
ATOM   3726 N N   . ALA C 1 61  ? 5.755   1.670   32.770  1.00 23.59  ? 61  ALA H N   1 
ATOM   3727 C CA  . ALA C 1 61  ? 5.578   0.501   33.625  1.00 25.02  ? 61  ALA H CA  1 
ATOM   3728 C C   . ALA C 1 61  ? 4.196   0.549   34.272  1.00 27.88  ? 61  ALA H C   1 
ATOM   3729 O O   . ALA C 1 61  ? 3.592   1.621   34.412  1.00 25.82  ? 61  ALA H O   1 
ATOM   3730 C CB  . ALA C 1 61  ? 6.639   0.409   34.692  1.00 22.98  ? 61  ALA H CB  1 
ATOM   3731 N N   . ASN C 1 62  ? 3.769   -0.624  34.746  1.00 30.71  ? 62  ASN H N   1 
ATOM   3732 C CA  . ASN C 1 62  ? 2.448   -0.815  35.315  1.00 36.04  ? 62  ASN H CA  1 
ATOM   3733 C C   . ASN C 1 62  ? 2.174   0.218   36.410  1.00 34.73  ? 62  ASN H C   1 
ATOM   3734 O O   . ASN C 1 62  ? 1.101   0.802   36.459  1.00 39.43  ? 62  ASN H O   1 
ATOM   3735 C CB  . ASN C 1 62  ? 2.292   -2.232  35.868  1.00 39.24  ? 62  ASN H CB  1 
ATOM   3736 C CG  . ASN C 1 62  ? 0.840   -2.628  35.994  1.00 52.65  ? 62  ASN H CG  1 
ATOM   3737 O OD1 . ASN C 1 62  ? 0.309   -2.738  37.099  1.00 60.05  ? 62  ASN H OD1 1 
ATOM   3738 N ND2 . ASN C 1 62  ? 0.182   -2.807  34.860  1.00 62.31  ? 62  ASN H ND2 1 
ATOM   3739 N N   . ASP C 1 63  ? 3.142   0.435   37.301  1.00 35.00  ? 63  ASP H N   1 
ATOM   3740 C CA  . ASP C 1 63  ? 2.959   1.295   38.468  1.00 37.53  ? 63  ASP H CA  1 
ATOM   3741 C C   . ASP C 1 63  ? 3.039   2.788   38.148  1.00 34.51  ? 63  ASP H C   1 
ATOM   3742 O O   . ASP C 1 63  ? 2.965   3.580   39.073  1.00 39.81  ? 63  ASP H O   1 
ATOM   3743 C CB  . ASP C 1 63  ? 4.036   1.046   39.525  1.00 39.19  ? 63  ASP H CB  1 
ATOM   3744 C CG  . ASP C 1 63  ? 4.019   -0.343  40.129  1.00 42.59  ? 63  ASP H CG  1 
ATOM   3745 O OD1 . ASP C 1 63  ? 2.998   -1.043  39.957  1.00 45.07  ? 63  ASP H OD1 1 
ATOM   3746 O OD2 . ASP C 1 63  ? 5.021   -0.701  40.778  1.00 40.22  ? 63  ASP H OD2 1 
ATOM   3747 N N   . PHE C 1 64  ? 3.183   3.173   36.873  1.00 31.31  ? 64  PHE H N   1 
ATOM   3748 C CA  . PHE C 1 64  ? 3.363   4.563   36.502  1.00 32.50  ? 64  PHE H CA  1 
ATOM   3749 C C   . PHE C 1 64  ? 2.391   4.920   35.392  1.00 35.71  ? 64  PHE H C   1 
ATOM   3750 O O   . PHE C 1 64  ? 2.784   5.306   34.297  1.00 42.59  ? 64  PHE H O   1 
ATOM   3751 C CB  . PHE C 1 64  ? 4.825   4.796   36.118  1.00 30.94  ? 64  PHE H CB  1 
ATOM   3752 C CG  . PHE C 1 64  ? 5.756   4.554   37.275  1.00 26.57  ? 64  PHE H CG  1 
ATOM   3753 C CD1 . PHE C 1 64  ? 5.951   5.537   38.227  1.00 26.05  ? 64  PHE H CD1 1 
ATOM   3754 C CD2 . PHE C 1 64  ? 6.339   3.319   37.462  1.00 24.71  ? 64  PHE H CD2 1 
ATOM   3755 C CE1 . PHE C 1 64  ? 6.764   5.304   39.322  1.00 25.67  ? 64  PHE H CE1 1 
ATOM   3756 C CE2 . PHE C 1 64  ? 7.157   3.087   38.548  1.00 22.80  ? 64  PHE H CE2 1 
ATOM   3757 C CZ  . PHE C 1 64  ? 7.369   4.080   39.472  1.00 25.24  ? 64  PHE H CZ  1 
ATOM   3758 N N   . LYS C 1 65  ? 1.114   4.802   35.720  1.00 44.08  ? 65  LYS H N   1 
ATOM   3759 C CA  . LYS C 1 65  ? 0.040   5.150   34.813  1.00 52.88  ? 65  LYS H CA  1 
ATOM   3760 C C   . LYS C 1 65  ? -0.636  6.382   35.392  1.00 52.38  ? 65  LYS H C   1 
ATOM   3761 O O   . LYS C 1 65  ? -0.948  6.396   36.577  1.00 73.00  ? 65  LYS H O   1 
ATOM   3762 C CB  . LYS C 1 65  ? -0.918  3.962   34.649  1.00 57.80  ? 65  LYS H CB  1 
ATOM   3763 C CG  . LYS C 1 65  ? -1.460  3.374   35.948  1.00 63.92  ? 65  LYS H CG  1 
ATOM   3764 C CD  . LYS C 1 65  ? -2.582  2.358   35.766  1.00 72.69  ? 65  LYS H CD  1 
ATOM   3765 C CE  . LYS C 1 65  ? -2.120  0.914   35.746  1.00 74.64  ? 65  LYS H CE  1 
ATOM   3766 N NZ  . LYS C 1 65  ? -1.256  0.609   34.582  1.00 73.86  ? 65  LYS H NZ  1 
ATOM   3767 N N   . GLY C 1 66  ? -0.776  7.433   34.581  1.00 49.64  ? 66  GLY H N   1 
ATOM   3768 C CA  . GLY C 1 66  ? -1.703  8.515   34.882  1.00 40.38  ? 66  GLY H CA  1 
ATOM   3769 C C   . GLY C 1 66  ? -0.985  9.815   35.220  1.00 35.35  ? 66  GLY H C   1 
ATOM   3770 O O   . GLY C 1 66  ? -1.006  10.776  34.453  1.00 38.50  ? 66  GLY H O   1 
ATOM   3771 N N   . ARG C 1 67  ? -0.312  9.833   36.366  1.00 31.32  ? 67  ARG H N   1 
ATOM   3772 C CA  . ARG C 1 67  ? 0.323   11.059  36.818  1.00 29.43  ? 67  ARG H CA  1 
ATOM   3773 C C   . ARG C 1 67  ? 1.685   11.285  36.161  1.00 28.22  ? 67  ARG H C   1 
ATOM   3774 O O   . ARG C 1 67  ? 2.178   12.404  36.251  1.00 29.43  ? 67  ARG H O   1 
ATOM   3775 C CB  . ARG C 1 67  ? 0.437   11.060  38.340  1.00 31.22  ? 67  ARG H CB  1 
ATOM   3776 C CG  . ARG C 1 67  ? -0.886  10.831  39.049  1.00 32.28  ? 67  ARG H CG  1 
ATOM   3777 C CD  . ARG C 1 67  ? -0.756  10.994  40.550  1.00 33.76  ? 67  ARG H CD  1 
ATOM   3778 N NE  . ARG C 1 67  ? 0.209   10.035  41.080  1.00 34.41  ? 67  ARG H NE  1 
ATOM   3779 C CZ  . ARG C 1 67  ? 1.298   10.343  41.788  1.00 32.70  ? 67  ARG H CZ  1 
ATOM   3780 N NH1 . ARG C 1 67  ? 1.675   11.603  41.951  1.00 31.53  ? 67  ARG H NH1 1 
ATOM   3781 N NH2 . ARG C 1 67  ? 2.031   9.365   42.299  1.00 31.90  ? 67  ARG H NH2 1 
ATOM   3782 N N   . PHE C 1 68  ? 2.255   10.281  35.455  1.00 27.02  ? 68  PHE H N   1 
ATOM   3783 C CA  . PHE C 1 68  ? 3.608   10.380  34.913  1.00 23.58  ? 68  PHE H CA  1 
ATOM   3784 C C   . PHE C 1 68  ? 3.601   10.491  33.393  1.00 22.88  ? 68  PHE H C   1 
ATOM   3785 O O   . PHE C 1 68  ? 2.992   9.663   32.719  1.00 20.60  ? 68  PHE H O   1 
ATOM   3786 C CB  . PHE C 1 68  ? 4.451   9.166   35.313  1.00 24.73  ? 68  PHE H CB  1 
ATOM   3787 C CG  . PHE C 1 68  ? 4.432   8.874   36.788  1.00 25.32  ? 68  PHE H CG  1 
ATOM   3788 C CD1 . PHE C 1 68  ? 3.349   8.227   37.364  1.00 28.19  ? 68  PHE H CD1 1 
ATOM   3789 C CD2 . PHE C 1 68  ? 5.451   9.329   37.610  1.00 25.51  ? 68  PHE H CD2 1 
ATOM   3790 C CE1 . PHE C 1 68  ? 3.312   7.990   38.734  1.00 30.04  ? 68  PHE H CE1 1 
ATOM   3791 C CE2 . PHE C 1 68  ? 5.411   9.098   38.976  1.00 27.88  ? 68  PHE H CE2 1 
ATOM   3792 C CZ  . PHE C 1 68  ? 4.349   8.423   39.539  1.00 29.94  ? 68  PHE H CZ  1 
ATOM   3793 N N   . VAL C 1 69  ? 4.288   11.521  32.862  1.00 20.35  ? 69  VAL H N   1 
ATOM   3794 C CA  . VAL C 1 69  ? 4.312   11.750  31.432  1.00 20.56  ? 69  VAL H CA  1 
ATOM   3795 C C   . VAL C 1 69  ? 5.768   11.897  30.989  1.00 19.97  ? 69  VAL H C   1 
ATOM   3796 O O   . VAL C 1 69  ? 6.495   12.735  31.525  1.00 22.70  ? 69  VAL H O   1 
ATOM   3797 C CB  . VAL C 1 69  ? 3.455   12.971  31.022  1.00 22.57  ? 69  VAL H CB  1 
ATOM   3798 C CG1 . VAL C 1 69  ? 3.684   13.353  29.563  1.00 23.37  ? 69  VAL H CG1 1 
ATOM   3799 C CG2 . VAL C 1 69  ? 1.964   12.741  31.254  1.00 22.26  ? 69  VAL H CG2 1 
ATOM   3800 N N   . PHE C 1 70  ? 6.174   11.114  29.981  1.00 17.66  ? 70  PHE H N   1 
ATOM   3801 C CA  . PHE C 1 70  ? 7.469   11.315  29.352  1.00 18.69  ? 70  PHE H CA  1 
ATOM   3802 C C   . PHE C 1 70  ? 7.279   12.139  28.083  1.00 17.89  ? 70  PHE H C   1 
ATOM   3803 O O   . PHE C 1 70  ? 6.336   11.908  27.353  1.00 19.43  ? 70  PHE H O   1 
ATOM   3804 C CB  . PHE C 1 70  ? 8.122   9.981   28.955  1.00 18.30  ? 70  PHE H CB  1 
ATOM   3805 C CG  . PHE C 1 70  ? 8.150   8.890   30.001  1.00 18.76  ? 70  PHE H CG  1 
ATOM   3806 C CD1 . PHE C 1 70  ? 8.163   9.174   31.356  1.00 19.74  ? 70  PHE H CD1 1 
ATOM   3807 C CD2 . PHE C 1 70  ? 8.208   7.558   29.618  1.00 17.45  ? 70  PHE H CD2 1 
ATOM   3808 C CE1 . PHE C 1 70  ? 8.220   8.151   32.300  1.00 19.98  ? 70  PHE H CE1 1 
ATOM   3809 C CE2 . PHE C 1 70  ? 8.273   6.543   30.555  1.00 17.63  ? 70  PHE H CE2 1 
ATOM   3810 C CZ  . PHE C 1 70  ? 8.263   6.837   31.895  1.00 18.27  ? 70  PHE H CZ  1 
ATOM   3811 N N   . SER C 1 71  ? 8.217   13.026  27.766  1.00 18.54  ? 71  SER H N   1 
ATOM   3812 C CA  . SER C 1 71  ? 8.193   13.740  26.497  1.00 19.21  ? 71  SER H CA  1 
ATOM   3813 C C   . SER C 1 71  ? 9.624   14.111  26.117  1.00 18.99  ? 71  SER H C   1 
ATOM   3814 O O   . SER C 1 71  ? 10.540  13.862  26.884  1.00 19.16  ? 71  SER H O   1 
ATOM   3815 C CB  . SER C 1 71  ? 7.350   15.001  26.633  1.00 20.25  ? 71  SER H CB  1 
ATOM   3816 O OG  . SER C 1 71  ? 7.969   15.840  27.610  1.00 19.79  ? 71  SER H OG  1 
ATOM   3817 N N   . LEU C 1 72  ? 9.775   14.779  24.970  1.00 19.91  ? 72  LEU H N   1 
ATOM   3818 C CA  . LEU C 1 72  ? 11.033  15.042  24.290  1.00 20.82  ? 72  LEU H CA  1 
ATOM   3819 C C   . LEU C 1 72  ? 11.069  16.507  23.858  1.00 20.53  ? 72  LEU H C   1 
ATOM   3820 O O   . LEU C 1 72  ? 10.022  17.040  23.553  1.00 17.37  ? 72  LEU H O   1 
ATOM   3821 C CB  . LEU C 1 72  ? 11.093  14.222  22.996  1.00 21.24  ? 72  LEU H CB  1 
ATOM   3822 C CG  . LEU C 1 72  ? 11.187  12.712  23.109  1.00 23.10  ? 72  LEU H CG  1 
ATOM   3823 C CD1 . LEU C 1 72  ? 11.413  12.133  21.717  1.00 23.49  ? 72  LEU H CD1 1 
ATOM   3824 C CD2 . LEU C 1 72  ? 12.303  12.296  24.058  1.00 22.62  ? 72  LEU H CD2 1 
ATOM   3825 N N   . ASP C 1 73  ? 12.281  17.089  23.775  1.00 21.76  ? 73  ASP H N   1 
ATOM   3826 C CA  . ASP C 1 73  ? 12.592  18.202  22.892  1.00 22.42  ? 73  ASP H CA  1 
ATOM   3827 C C   . ASP C 1 73  ? 13.891  17.860  22.160  1.00 21.02  ? 73  ASP H C   1 
ATOM   3828 O O   . ASP C 1 73  ? 14.983  18.029  22.691  1.00 16.89  ? 73  ASP H O   1 
ATOM   3829 C CB  . ASP C 1 73  ? 12.698  19.519  23.669  1.00 25.32  ? 73  ASP H CB  1 
ATOM   3830 C CG  . ASP C 1 73  ? 12.907  20.752  22.787  1.00 27.97  ? 73  ASP H CG  1 
ATOM   3831 O OD1 . ASP C 1 73  ? 13.227  20.590  21.601  1.00 29.01  ? 73  ASP H OD1 1 
ATOM   3832 O OD2 . ASP C 1 73  ? 12.743  21.874  23.300  1.00 31.16  ? 73  ASP H OD2 1 
ATOM   3833 N N   . THR C 1 74  ? 13.761  17.352  20.938  1.00 20.74  ? 74  THR H N   1 
ATOM   3834 C CA  . THR C 1 74  ? 14.912  16.844  20.223  1.00 23.69  ? 74  THR H CA  1 
ATOM   3835 C C   . THR C 1 74  ? 15.813  18.006  19.782  1.00 22.99  ? 74  THR H C   1 
ATOM   3836 O O   . THR C 1 74  ? 16.996  17.766  19.547  1.00 20.56  ? 74  THR H O   1 
ATOM   3837 C CB  . THR C 1 74  ? 14.493  15.893  19.088  1.00 25.99  ? 74  THR H CB  1 
ATOM   3838 O OG1 . THR C 1 74  ? 13.792  16.619  18.088  1.00 26.09  ? 74  THR H OG1 1 
ATOM   3839 C CG2 . THR C 1 74  ? 13.589  14.758  19.538  1.00 26.78  ? 74  THR H CG2 1 
ATOM   3840 N N   . SER C 1 75  ? 15.274  19.242  19.714  1.00 21.14  ? 75  SER H N   1 
ATOM   3841 C CA  . SER C 1 75  ? 16.041  20.420  19.325  1.00 23.32  ? 75  SER H CA  1 
ATOM   3842 C C   . SER C 1 75  ? 17.106  20.727  20.375  1.00 22.56  ? 75  SER H C   1 
ATOM   3843 O O   . SER C 1 75  ? 18.072  21.410  20.069  1.00 23.82  ? 75  SER H O   1 
ATOM   3844 C CB  . SER C 1 75  ? 15.163  21.659  19.062  1.00 22.94  ? 75  SER H CB  1 
ATOM   3845 O OG  . SER C 1 75  ? 14.676  22.220  20.281  1.00 19.21  ? 75  SER H OG  1 
ATOM   3846 N N   . VAL C 1 76  ? 16.929  20.251  21.621  1.00 24.12  ? 76  VAL H N   1 
ATOM   3847 C CA  . VAL C 1 76  ? 17.959  20.412  22.646  1.00 23.38  ? 76  VAL H CA  1 
ATOM   3848 C C   . VAL C 1 76  ? 18.337  19.052  23.259  1.00 22.60  ? 76  VAL H C   1 
ATOM   3849 O O   . VAL C 1 76  ? 18.808  18.994  24.393  1.00 22.69  ? 76  VAL H O   1 
ATOM   3850 C CB  . VAL C 1 76  ? 17.519  21.436  23.712  1.00 24.47  ? 76  VAL H CB  1 
ATOM   3851 C CG1 . VAL C 1 76  ? 17.402  22.830  23.126  1.00 24.57  ? 76  VAL H CG1 1 
ATOM   3852 C CG2 . VAL C 1 76  ? 16.210  21.034  24.378  1.00 25.54  ? 76  VAL H CG2 1 
ATOM   3853 N N   . SER C 1 77  ? 18.143  17.959  22.505  1.00 21.54  ? 77  SER H N   1 
ATOM   3854 C CA  . SER C 1 77  ? 18.576  16.627  22.910  1.00 21.69  ? 77  SER H CA  1 
ATOM   3855 C C   . SER C 1 77  ? 18.165  16.317  24.348  1.00 20.21  ? 77  SER H C   1 
ATOM   3856 O O   . SER C 1 77  ? 18.994  15.879  25.155  1.00 17.70  ? 77  SER H O   1 
ATOM   3857 C CB  . SER C 1 77  ? 20.064  16.512  22.769  1.00 22.06  ? 77  SER H CB  1 
ATOM   3858 O OG  . SER C 1 77  ? 20.429  16.726  21.435  1.00 23.64  ? 77  SER H OG  1 
ATOM   3859 N N   . THR C 1 78  ? 16.904  16.615  24.685  1.00 19.38  ? 78  THR H N   1 
ATOM   3860 C CA  . THR C 1 78  ? 16.474  16.530  26.062  1.00 18.68  ? 78  THR H CA  1 
ATOM   3861 C C   . THR C 1 78  ? 15.237  15.626  26.178  1.00 20.56  ? 78  THR H C   1 
ATOM   3862 O O   . THR C 1 78  ? 14.331  15.673  25.347  1.00 20.06  ? 78  THR H O   1 
ATOM   3863 C CB  . THR C 1 78  ? 16.301  17.947  26.623  1.00 19.64  ? 78  THR H CB  1 
ATOM   3864 O OG1 . THR C 1 78  ? 17.551  18.646  26.603  1.00 18.47  ? 78  THR H OG1 1 
ATOM   3865 C CG2 . THR C 1 78  ? 15.812  17.940  28.044  1.00 21.09  ? 78  THR H CG2 1 
ATOM   3866 N N   . ALA C 1 79  ? 15.209  14.804  27.244  1.00 18.64  ? 79  ALA H N   1 
ATOM   3867 C CA  . ALA C 1 79  ? 14.037  14.022  27.607  1.00 18.37  ? 79  ALA H CA  1 
ATOM   3868 C C   . ALA C 1 79  ? 13.487  14.616  28.889  1.00 16.83  ? 79  ALA H C   1 
ATOM   3869 O O   . ALA C 1 79  ? 14.250  15.075  29.733  1.00 17.92  ? 79  ALA H O   1 
ATOM   3870 C CB  . ALA C 1 79  ? 14.396  12.562  27.792  1.00 17.74  ? 79  ALA H CB  1 
ATOM   3871 N N   . TYR C 1 80  ? 12.177  14.600  29.044  1.00 15.72  ? 80  TYR H N   1 
ATOM   3872 C CA  . TYR C 1 80  ? 11.579  15.203  30.220  1.00 16.93  ? 80  TYR H CA  1 
ATOM   3873 C C   . TYR C 1 80  ? 10.719  14.180  30.932  1.00 18.69  ? 80  TYR H C   1 
ATOM   3874 O O   . TYR C 1 80  ? 10.123  13.328  30.281  1.00 17.47  ? 80  TYR H O   1 
ATOM   3875 C CB  . TYR C 1 80  ? 10.696  16.383  29.828  1.00 18.16  ? 80  TYR H CB  1 
ATOM   3876 C CG  . TYR C 1 80  ? 11.429  17.536  29.187  1.00 20.71  ? 80  TYR H CG  1 
ATOM   3877 C CD1 . TYR C 1 80  ? 12.101  18.474  29.949  1.00 23.17  ? 80  TYR H CD1 1 
ATOM   3878 C CD2 . TYR C 1 80  ? 11.425  17.713  27.818  1.00 22.49  ? 80  TYR H CD2 1 
ATOM   3879 C CE1 . TYR C 1 80  ? 12.757  19.558  29.381  1.00 24.29  ? 80  TYR H CE1 1 
ATOM   3880 C CE2 . TYR C 1 80  ? 12.052  18.800  27.226  1.00 24.87  ? 80  TYR H CE2 1 
ATOM   3881 C CZ  . TYR C 1 80  ? 12.734  19.720  28.009  1.00 26.69  ? 80  TYR H CZ  1 
ATOM   3882 O OH  . TYR C 1 80  ? 13.408  20.778  27.465  1.00 28.85  ? 80  TYR H OH  1 
ATOM   3883 N N   . LEU C 1 81  ? 10.692  14.284  32.264  1.00 20.12  ? 81  LEU H N   1 
ATOM   3884 C CA  . LEU C 1 81  ? 9.769   13.541  33.095  1.00 20.96  ? 81  LEU H CA  1 
ATOM   3885 C C   . LEU C 1 81  ? 8.874   14.533  33.832  1.00 23.07  ? 81  LEU H C   1 
ATOM   3886 O O   . LEU C 1 81  ? 9.380   15.401  34.530  1.00 23.26  ? 81  LEU H O   1 
ATOM   3887 C CB  . LEU C 1 81  ? 10.568  12.698  34.086  1.00 20.62  ? 81  LEU H CB  1 
ATOM   3888 C CG  . LEU C 1 81  ? 9.739   12.067  35.201  1.00 21.35  ? 81  LEU H CG  1 
ATOM   3889 C CD1 . LEU C 1 81  ? 8.705   11.117  34.645  1.00 20.40  ? 81  LEU H CD1 1 
ATOM   3890 C CD2 . LEU C 1 81  ? 10.611  11.347  36.202  1.00 22.65  ? 81  LEU H CD2 1 
ATOM   3891 N N   . GLN C 1 82  ? 7.552   14.389  33.665  1.00 23.72  ? 82  GLN H N   1 
ATOM   3892 C CA  . GLN C 1 82  ? 6.586   15.240  34.336  1.00 25.81  ? 82  GLN H CA  1 
ATOM   3893 C C   . GLN C 1 82  ? 5.737   14.351  35.231  1.00 21.68  ? 82  GLN H C   1 
ATOM   3894 O O   . GLN C 1 82  ? 5.250   13.319  34.784  1.00 23.07  ? 82  GLN H O   1 
ATOM   3895 C CB  . GLN C 1 82  ? 5.720   16.005  33.321  1.00 31.94  ? 82  GLN H CB  1 
ATOM   3896 C CG  . GLN C 1 82  ? 4.634   16.879  33.964  1.00 41.83  ? 82  GLN H CG  1 
ATOM   3897 C CD  . GLN C 1 82  ? 4.801   18.380  33.785  1.00 48.51  ? 82  GLN H CD  1 
ATOM   3898 O OE1 . GLN C 1 82  ? 5.170   19.112  34.712  1.00 46.12  ? 82  GLN H OE1 1 
ATOM   3899 N NE2 . GLN C 1 82  ? 4.492   18.863  32.587  1.00 45.36  ? 82  GLN H NE2 1 
ATOM   3900 N N   . ILE C 1 83  ? 5.623   14.741  36.498  1.00 20.61  ? 83  ILE H N   1 
ATOM   3901 C CA  . ILE C 1 83  ? 4.755   14.102  37.472  1.00 23.25  ? 83  ILE H CA  1 
ATOM   3902 C C   . ILE C 1 83  ? 3.761   15.154  37.950  1.00 23.61  ? 83  ILE H C   1 
ATOM   3903 O O   . ILE C 1 83  ? 4.161   16.259  38.283  1.00 24.85  ? 83  ILE H O   1 
ATOM   3904 C CB  . ILE C 1 83  ? 5.578   13.570  38.654  1.00 24.77  ? 83  ILE H CB  1 
ATOM   3905 C CG1 . ILE C 1 83  ? 6.798   12.770  38.183  1.00 25.39  ? 83  ILE H CG1 1 
ATOM   3906 C CG2 . ILE C 1 83  ? 4.706   12.798  39.632  1.00 23.72  ? 83  ILE H CG2 1 
ATOM   3907 C CD1 . ILE C 1 83  ? 7.765   12.424  39.292  1.00 25.54  ? 83  ILE H CD1 1 
ATOM   3908 N N   . SER C 1 84  ? 2.476   14.821  37.959  1.00 25.57  ? 84  SER H N   1 
ATOM   3909 C CA  . SER C 1 84  ? 1.443   15.740  38.414  1.00 28.77  ? 84  SER H CA  1 
ATOM   3910 C C   . SER C 1 84  ? 0.825   15.212  39.710  1.00 29.68  ? 84  SER H C   1 
ATOM   3911 O O   . SER C 1 84  ? 1.006   14.042  40.058  1.00 31.73  ? 84  SER H O   1 
ATOM   3912 C CB  . SER C 1 84  ? 0.412   15.938  37.317  1.00 29.30  ? 84  SER H CB  1 
ATOM   3913 O OG  . SER C 1 84  ? -0.194  14.700  36.959  1.00 29.97  ? 84  SER H OG  1 
ATOM   3914 N N   . SER C 1 85  ? 0.117   16.086  40.444  1.00 32.13  ? 85  SER H N   1 
ATOM   3915 C CA  . SER C 1 85  ? -0.581  15.707  41.669  1.00 30.56  ? 85  SER H CA  1 
ATOM   3916 C C   . SER C 1 85  ? 0.362   15.006  42.654  1.00 30.96  ? 85  SER H C   1 
ATOM   3917 O O   . SER C 1 85  ? 0.073   13.931  43.168  1.00 30.77  ? 85  SER H O   1 
ATOM   3918 C CB  . SER C 1 85  ? -1.782  14.845  41.365  1.00 32.62  ? 85  SER H CB  1 
ATOM   3919 O OG  . SER C 1 85  ? -2.722  15.549  40.566  1.00 33.42  ? 85  SER H OG  1 
ATOM   3920 N N   . LEU C 1 86  ? 1.481   15.667  42.969  1.00 32.70  ? 86  LEU H N   1 
ATOM   3921 C CA  . LEU C 1 86  ? 2.527   15.069  43.780  1.00 29.12  ? 86  LEU H CA  1 
ATOM   3922 C C   . LEU C 1 86  ? 1.985   14.754  45.173  1.00 31.03  ? 86  LEU H C   1 
ATOM   3923 O O   . LEU C 1 86  ? 1.250   15.559  45.750  1.00 32.82  ? 86  LEU H O   1 
ATOM   3924 C CB  . LEU C 1 86  ? 3.706   16.051  43.829  1.00 25.57  ? 86  LEU H CB  1 
ATOM   3925 C CG  . LEU C 1 86  ? 4.520   16.190  42.547  1.00 22.80  ? 86  LEU H CG  1 
ATOM   3926 C CD1 . LEU C 1 86  ? 5.386   17.419  42.597  1.00 22.91  ? 86  LEU H CD1 1 
ATOM   3927 C CD2 . LEU C 1 86  ? 5.424   14.992  42.332  1.00 22.83  ? 86  LEU H CD2 1 
ATOM   3928 N N   . LYS C 1 87  ? 2.389   13.592  45.702  1.00 31.51  ? 87  LYS H N   1 
ATOM   3929 C CA  . LYS C 1 87  ? 2.188   13.205  47.090  1.00 32.79  ? 87  LYS H CA  1 
ATOM   3930 C C   . LYS C 1 87  ? 3.528   13.102  47.825  1.00 33.44  ? 87  LYS H C   1 
ATOM   3931 O O   . LYS C 1 87  ? 4.582   13.059  47.189  1.00 30.94  ? 87  LYS H O   1 
ATOM   3932 C CB  . LYS C 1 87  ? 1.640   11.782  47.221  1.00 38.13  ? 87  LYS H CB  1 
ATOM   3933 C CG  . LYS C 1 87  ? 0.518   11.334  46.297  1.00 43.91  ? 87  LYS H CG  1 
ATOM   3934 C CD  . LYS C 1 87  ? 0.359   9.800   46.328  1.00 49.45  ? 87  LYS H CD  1 
ATOM   3935 C CE  . LYS C 1 87  ? -0.979  9.284   45.831  1.00 52.50  ? 87  LYS H CE  1 
ATOM   3936 N NZ  . LYS C 1 87  ? -1.361  9.850   44.511  1.00 52.50  ? 87  LYS H NZ  1 
ATOM   3937 N N   . ALA C 1 88  ? 3.468   12.937  49.158  1.00 31.54  ? 88  ALA H N   1 
ATOM   3938 C CA  . ALA C 1 88  ? 4.644   12.740  50.000  1.00 36.04  ? 88  ALA H CA  1 
ATOM   3939 C C   . ALA C 1 88  ? 5.533   11.597  49.491  1.00 34.64  ? 88  ALA H C   1 
ATOM   3940 O O   . ALA C 1 88  ? 6.752   11.717  49.491  1.00 35.88  ? 88  ALA H O   1 
ATOM   3941 C CB  . ALA C 1 88  ? 4.218   12.483  51.431  1.00 34.92  ? 88  ALA H CB  1 
ATOM   3942 N N   . GLU C 1 89  ? 4.914   10.510  49.025  1.00 34.03  ? 89  GLU H N   1 
ATOM   3943 C CA  . GLU C 1 89  ? 5.622   9.291   48.690  1.00 35.71  ? 89  GLU H CA  1 
ATOM   3944 C C   . GLU C 1 89  ? 6.184   9.351   47.265  1.00 31.82  ? 89  GLU H C   1 
ATOM   3945 O O   . GLU C 1 89  ? 6.808   8.395   46.844  1.00 26.21  ? 89  GLU H O   1 
ATOM   3946 C CB  . GLU C 1 89  ? 4.753   8.051   48.950  1.00 44.66  ? 89  GLU H CB  1 
ATOM   3947 C CG  . GLU C 1 89  ? 3.250   8.232   48.758  1.00 56.19  ? 89  GLU H CG  1 
ATOM   3948 C CD  . GLU C 1 89  ? 2.486   8.944   49.875  1.00 57.79  ? 89  GLU H CD  1 
ATOM   3949 O OE1 . GLU C 1 89  ? 2.175   8.294   50.905  1.00 61.79  ? 89  GLU H OE1 1 
ATOM   3950 O OE2 . GLU C 1 89  ? 2.206   10.157  49.716  1.00 45.48  ? 89  GLU H OE2 1 
ATOM   3951 N N   . ASP C 1 90  ? 6.012   10.470  46.544  1.00 28.77  ? 90  ASP H N   1 
ATOM   3952 C CA  . ASP C 1 90  ? 6.773   10.745  45.330  1.00 29.84  ? 90  ASP H CA  1 
ATOM   3953 C C   . ASP C 1 90  ? 8.154   11.327  45.665  1.00 26.87  ? 90  ASP H C   1 
ATOM   3954 O O   . ASP C 1 90  ? 8.953   11.576  44.758  1.00 25.82  ? 90  ASP H O   1 
ATOM   3955 C CB  . ASP C 1 90  ? 6.032   11.673  44.359  1.00 28.55  ? 90  ASP H CB  1 
ATOM   3956 C CG  . ASP C 1 90  ? 4.685   11.145  43.858  1.00 31.14  ? 90  ASP H CG  1 
ATOM   3957 O OD1 . ASP C 1 90  ? 4.616   9.959   43.461  1.00 29.07  ? 90  ASP H OD1 1 
ATOM   3958 O OD2 . ASP C 1 90  ? 3.717   11.952  43.797  1.00 31.46  ? 90  ASP H OD2 1 
ATOM   3959 N N   . THR C 1 91  ? 8.452   11.531  46.958  1.00 24.81  ? 91  THR H N   1 
ATOM   3960 C CA  . THR C 1 91  ? 9.778   12.004  47.349  1.00 23.91  ? 91  THR H CA  1 
ATOM   3961 C C   . THR C 1 91  ? 10.786  10.900  46.999  1.00 22.52  ? 91  THR H C   1 
ATOM   3962 O O   . THR C 1 91  ? 10.685  9.789   47.478  1.00 21.66  ? 91  THR H O   1 
ATOM   3963 C CB  . THR C 1 91  ? 9.803   12.424  48.830  1.00 23.55  ? 91  THR H CB  1 
ATOM   3964 O OG1 . THR C 1 91  ? 8.941   13.565  48.970  1.00 22.49  ? 91  THR H OG1 1 
ATOM   3965 C CG2 . THR C 1 91  ? 11.193  12.756  49.344  1.00 21.34  ? 91  THR H CG2 1 
ATOM   3966 N N   . ALA C 1 92  ? 11.689  11.174  46.062  1.00 20.08  ? 92  ALA H N   1 
ATOM   3967 C CA  . ALA C 1 92  ? 12.536  10.139  45.528  1.00 19.46  ? 92  ALA H CA  1 
ATOM   3968 C C   . ALA C 1 92  ? 13.588  10.815  44.674  1.00 19.52  ? 92  ALA H C   1 
ATOM   3969 O O   . ALA C 1 92  ? 13.412  11.973  44.299  1.00 18.25  ? 92  ALA H O   1 
ATOM   3970 C CB  . ALA C 1 92  ? 11.734  9.174   44.695  1.00 19.22  ? 92  ALA H CB  1 
ATOM   3971 N N   . VAL C 1 93  ? 14.634  10.061  44.328  1.00 17.99  ? 93  VAL H N   1 
ATOM   3972 C CA  . VAL C 1 93  ? 15.543  10.470  43.269  1.00 18.18  ? 93  VAL H CA  1 
ATOM   3973 C C   . VAL C 1 93  ? 15.063  9.832   41.970  1.00 16.12  ? 93  VAL H C   1 
ATOM   3974 O O   . VAL C 1 93  ? 14.708  8.668   41.952  1.00 16.90  ? 93  VAL H O   1 
ATOM   3975 C CB  . VAL C 1 93  ? 16.984  10.055  43.619  1.00 19.83  ? 93  VAL H CB  1 
ATOM   3976 C CG1 . VAL C 1 93  ? 17.951  10.274  42.462  1.00 21.50  ? 93  VAL H CG1 1 
ATOM   3977 C CG2 . VAL C 1 93  ? 17.474  10.763  44.876  1.00 18.75  ? 93  VAL H CG2 1 
ATOM   3978 N N   . TYR C 1 94  ? 15.075  10.608  40.885  1.00 16.73  ? 94  TYR H N   1 
ATOM   3979 C CA  . TYR C 1 94  ? 14.672  10.169  39.564  1.00 14.68  ? 94  TYR H CA  1 
ATOM   3980 C C   . TYR C 1 94  ? 15.877  10.233  38.641  1.00 15.61  ? 94  TYR H C   1 
ATOM   3981 O O   . TYR C 1 94  ? 16.572  11.251  38.600  1.00 18.49  ? 94  TYR H O   1 
ATOM   3982 C CB  . TYR C 1 94  ? 13.510  11.047  39.076  1.00 15.81  ? 94  TYR H CB  1 
ATOM   3983 C CG  . TYR C 1 94  ? 12.258  10.862  39.892  1.00 15.18  ? 94  TYR H CG  1 
ATOM   3984 C CD1 . TYR C 1 94  ? 12.034  11.590  41.044  1.00 15.84  ? 94  TYR H CD1 1 
ATOM   3985 C CD2 . TYR C 1 94  ? 11.345  9.877   39.565  1.00 15.60  ? 94  TYR H CD2 1 
ATOM   3986 C CE1 . TYR C 1 94  ? 10.879  11.431  41.799  1.00 15.38  ? 94  TYR H CE1 1 
ATOM   3987 C CE2 . TYR C 1 94  ? 10.208  9.678   40.326  1.00 16.21  ? 94  TYR H CE2 1 
ATOM   3988 C CZ  . TYR C 1 94  ? 9.990   10.437  41.460  1.00 16.07  ? 94  TYR H CZ  1 
ATOM   3989 O OH  . TYR C 1 94  ? 8.869   10.238  42.196  1.00 17.69  ? 94  TYR H OH  1 
ATOM   3990 N N   . TYR C 1 95  ? 16.117  9.147   37.897  1.00 13.62  ? 95  TYR H N   1 
ATOM   3991 C CA  . TYR C 1 95  ? 17.255  9.051   36.999  1.00 13.35  ? 95  TYR H CA  1 
ATOM   3992 C C   . TYR C 1 95  ? 16.775  8.861   35.570  1.00 12.77  ? 95  TYR H C   1 
ATOM   3993 O O   . TYR C 1 95  ? 15.814  8.122   35.318  1.00 12.96  ? 95  TYR H O   1 
ATOM   3994 C CB  . TYR C 1 95  ? 18.113  7.807   37.294  1.00 12.95  ? 95  TYR H CB  1 
ATOM   3995 C CG  . TYR C 1 95  ? 18.817  7.822   38.615  1.00 12.51  ? 95  TYR H CG  1 
ATOM   3996 C CD1 . TYR C 1 95  ? 20.028  8.474   38.769  1.00 12.33  ? 95  TYR H CD1 1 
ATOM   3997 C CD2 . TYR C 1 95  ? 18.290  7.165   39.720  1.00 12.61  ? 95  TYR H CD2 1 
ATOM   3998 C CE1 . TYR C 1 95  ? 20.667  8.510   39.999  1.00 11.93  ? 95  TYR H CE1 1 
ATOM   3999 C CE2 . TYR C 1 95  ? 18.939  7.154   40.942  1.00 11.93  ? 95  TYR H CE2 1 
ATOM   4000 C CZ  . TYR C 1 95  ? 20.128  7.848   41.085  1.00 13.09  ? 95  TYR H CZ  1 
ATOM   4001 O OH  . TYR C 1 95  ? 20.775  7.872   42.313  1.00 13.50  ? 95  TYR H OH  1 
ATOM   4002 N N   . CYS C 1 96  ? 17.474  9.469   34.618  1.00 12.03  ? 96  CYS H N   1 
ATOM   4003 C CA  . CYS C 1 96  ? 17.337  9.017   33.253  1.00 13.14  ? 96  CYS H CA  1 
ATOM   4004 C C   . CYS C 1 96  ? 18.505  8.082   32.996  1.00 12.69  ? 96  CYS H C   1 
ATOM   4005 O O   . CYS C 1 96  ? 19.551  8.217   33.623  1.00 12.54  ? 96  CYS H O   1 
ATOM   4006 C CB  . CYS C 1 96  ? 17.316  10.155  32.256  1.00 15.82  ? 96  CYS H CB  1 
ATOM   4007 S SG  . CYS C 1 96  ? 18.790  11.206  32.370  1.00 20.94  ? 96  CYS H SG  1 
ATOM   4008 N N   . ALA C 1 97  ? 18.279  7.109   32.128  1.00 13.66  ? 97  ALA H N   1 
ATOM   4009 C CA  . ALA C 1 97  ? 19.250  6.067   31.806  1.00 13.70  ? 97  ALA H CA  1 
ATOM   4010 C C   . ALA C 1 97  ? 19.094  5.655   30.350  1.00 13.48  ? 97  ALA H C   1 
ATOM   4011 O O   . ALA C 1 97  ? 18.042  5.127   29.993  1.00 13.41  ? 97  ALA H O   1 
ATOM   4012 C CB  . ALA C 1 97  ? 19.019  4.872   32.697  1.00 14.24  ? 97  ALA H CB  1 
ATOM   4013 N N   . ARG C 1 98  ? 20.142  5.855   29.547  1.00 14.09  ? 98  ARG H N   1 
ATOM   4014 C CA  . ARG C 1 98  ? 20.098  5.590   28.117  1.00 15.54  ? 98  ARG H CA  1 
ATOM   4015 C C   . ARG C 1 98  ? 20.195  4.090   27.819  1.00 17.07  ? 98  ARG H C   1 
ATOM   4016 O O   . ARG C 1 98  ? 20.878  3.340   28.510  1.00 16.11  ? 98  ARG H O   1 
ATOM   4017 C CB  . ARG C 1 98  ? 21.218  6.352   27.416  1.00 18.02  ? 98  ARG H CB  1 
ATOM   4018 C CG  . ARG C 1 98  ? 21.094  6.426   25.903  1.00 20.05  ? 98  ARG H CG  1 
ATOM   4019 C CD  . ARG C 1 98  ? 22.109  5.482   25.296  1.00 23.32  ? 98  ARG H CD  1 
ATOM   4020 N NE  . ARG C 1 98  ? 23.234  6.229   24.884  1.00 23.19  ? 98  ARG H NE  1 
ATOM   4021 C CZ  . ARG C 1 98  ? 24.288  5.764   24.257  1.00 21.61  ? 98  ARG H CZ  1 
ATOM   4022 N NH1 . ARG C 1 98  ? 24.607  4.492   24.280  1.00 20.76  ? 98  ARG H NH1 1 
ATOM   4023 N NH2 . ARG C 1 98  ? 25.082  6.645   23.687  1.00 22.22  ? 98  ARG H NH2 1 
ATOM   4024 N N   . ASP C 1 99  ? 19.440  3.646   26.804  1.00 17.09  ? 99  ASP H N   1 
ATOM   4025 C CA  . ASP C 1 99  ? 19.596  2.309   26.264  1.00 16.28  ? 99  ASP H CA  1 
ATOM   4026 C C   . ASP C 1 99  ? 21.035  2.123   25.799  1.00 15.48  ? 99  ASP H C   1 
ATOM   4027 O O   . ASP C 1 99  ? 21.593  3.012   25.153  1.00 12.96  ? 99  ASP H O   1 
ATOM   4028 C CB  . ASP C 1 99  ? 18.738  2.077   25.025  1.00 17.51  ? 99  ASP H CB  1 
ATOM   4029 C CG  . ASP C 1 99  ? 17.260  1.889   25.251  1.00 18.45  ? 99  ASP H CG  1 
ATOM   4030 O OD1 . ASP C 1 99  ? 16.857  1.801   26.404  1.00 24.55  ? 99  ASP H OD1 1 
ATOM   4031 O OD2 . ASP C 1 99  ? 16.538  1.798   24.259  1.00 18.27  ? 99  ASP H OD2 1 
ATOM   4032 N N   . TRP C 1 100 ? 21.587  0.947   26.115  1.00 14.95  ? 100 TRP H N   1 
ATOM   4033 C CA  . TRP C 1 100 ? 22.836  0.430   25.568  1.00 15.24  ? 100 TRP H CA  1 
ATOM   4034 C C   . TRP C 1 100 ? 24.024  1.137   26.200  1.00 17.05  ? 100 TRP H C   1 
ATOM   4035 O O   . TRP C 1 100 ? 24.416  2.247   25.810  1.00 15.73  ? 100 TRP H O   1 
ATOM   4036 C CB  . TRP C 1 100 ? 22.893  0.465   24.040  1.00 15.81  ? 100 TRP H CB  1 
ATOM   4037 C CG  . TRP C 1 100 ? 21.754  -0.258  23.395  1.00 18.44  ? 100 TRP H CG  1 
ATOM   4038 C CD1 . TRP C 1 100 ? 20.808  0.290   22.576  1.00 18.89  ? 100 TRP H CD1 1 
ATOM   4039 C CD2 . TRP C 1 100 ? 21.362  -1.626  23.612  1.00 17.98  ? 100 TRP H CD2 1 
ATOM   4040 N NE1 . TRP C 1 100 ? 19.875  -0.652  22.240  1.00 18.44  ? 100 TRP H NE1 1 
ATOM   4041 C CE2 . TRP C 1 100 ? 20.204  -1.846  22.837  1.00 19.79  ? 100 TRP H CE2 1 
ATOM   4042 C CE3 . TRP C 1 100 ? 21.882  -2.685  24.361  1.00 19.13  ? 100 TRP H CE3 1 
ATOM   4043 C CZ2 . TRP C 1 100 ? 19.552  -3.083  22.809  1.00 19.39  ? 100 TRP H CZ2 1 
ATOM   4044 C CZ3 . TRP C 1 100 ? 21.267  -3.925  24.298  1.00 18.73  ? 100 TRP H CZ3 1 
ATOM   4045 C CH2 . TRP C 1 100 ? 20.115  -4.112  23.535  1.00 19.67  ? 100 TRP H CH2 1 
ATOM   4046 N N   . GLY C 1 101 ? 24.617  0.418   27.146  1.00 16.04  ? 101 GLY H N   1 
ATOM   4047 C CA  . GLY C 1 101 ? 25.830  0.829   27.804  1.00 16.29  ? 101 GLY H CA  1 
ATOM   4048 C C   . GLY C 1 101 ? 25.617  1.279   29.239  1.00 15.81  ? 101 GLY H C   1 
ATOM   4049 O O   . GLY C 1 101 ? 24.706  0.833   29.936  1.00 16.04  ? 101 GLY H O   1 
ATOM   4050 N N   . PRO C 1 102 ? 26.541  2.145   29.704  1.00 15.13  ? 102 PRO H N   1 
ATOM   4051 C CA  . PRO C 1 102 ? 26.596  2.565   31.098  1.00 15.43  ? 102 PRO H CA  1 
ATOM   4052 C C   . PRO C 1 102 ? 26.050  3.920   31.509  1.00 15.64  ? 102 PRO H C   1 
ATOM   4053 O O   . PRO C 1 102 ? 26.248  4.309   32.653  1.00 15.13  ? 102 PRO H O   1 
ATOM   4054 C CB  . PRO C 1 102 ? 28.122  2.606   31.316  1.00 15.07  ? 102 PRO H CB  1 
ATOM   4055 C CG  . PRO C 1 102 ? 28.686  3.103   29.995  1.00 14.55  ? 102 PRO H CG  1 
ATOM   4056 C CD  . PRO C 1 102 ? 27.737  2.562   28.947  1.00 15.03  ? 102 PRO H CD  1 
ATOM   4057 N N   . TYR C 1 103 ? 25.297  4.586   30.638  1.00 15.82  ? 103 TYR H N   1 
ATOM   4058 C CA  . TYR C 1 103 ? 25.057  6.015   30.829  1.00 15.79  ? 103 TYR H CA  1 
ATOM   4059 C C   . TYR C 1 103 ? 23.778  6.282   31.583  1.00 14.49  ? 103 TYR H C   1 
ATOM   4060 O O   . TYR C 1 103 ? 22.674  5.968   31.097  1.00 14.91  ? 103 TYR H O   1 
ATOM   4061 C CB  . TYR C 1 103 ? 25.007  6.732   29.484  1.00 15.59  ? 103 TYR H CB  1 
ATOM   4062 C CG  . TYR C 1 103 ? 26.264  6.481   28.713  1.00 16.90  ? 103 TYR H CG  1 
ATOM   4063 C CD1 . TYR C 1 103 ? 27.475  6.984   29.170  1.00 19.10  ? 103 TYR H CD1 1 
ATOM   4064 C CD2 . TYR C 1 103 ? 26.251  5.766   27.527  1.00 19.27  ? 103 TYR H CD2 1 
ATOM   4065 C CE1 . TYR C 1 103 ? 28.653  6.794   28.452  1.00 20.13  ? 103 TYR H CE1 1 
ATOM   4066 C CE2 . TYR C 1 103 ? 27.411  5.585   26.783  1.00 20.22  ? 103 TYR H CE2 1 
ATOM   4067 C CZ  . TYR C 1 103 ? 28.611  6.094   27.252  1.00 21.13  ? 103 TYR H CZ  1 
ATOM   4068 O OH  . TYR C 1 103 ? 29.746  5.853   26.537  1.00 23.82  ? 103 TYR H OH  1 
ATOM   4069 N N   . TRP C 1 104 ? 23.988  6.948   32.723  1.00 14.03  ? 104 TRP H N   1 
ATOM   4070 C CA  . TRP C 1 104 ? 22.970  7.376   33.652  1.00 13.87  ? 104 TRP H CA  1 
ATOM   4071 C C   . TRP C 1 104 ? 23.134  8.869   33.909  1.00 16.33  ? 104 TRP H C   1 
ATOM   4072 O O   . TRP C 1 104 ? 24.263  9.366   34.000  1.00 13.76  ? 104 TRP H O   1 
ATOM   4073 C CB  . TRP C 1 104 ? 23.102  6.616   34.966  1.00 14.83  ? 104 TRP H CB  1 
ATOM   4074 C CG  . TRP C 1 104 ? 22.610  5.197   34.947  1.00 14.64  ? 104 TRP H CG  1 
ATOM   4075 C CD1 . TRP C 1 104 ? 23.154  4.147   34.271  1.00 13.68  ? 104 TRP H CD1 1 
ATOM   4076 C CD2 . TRP C 1 104 ? 21.451  4.690   35.632  1.00 13.18  ? 104 TRP H CD2 1 
ATOM   4077 N NE1 . TRP C 1 104 ? 22.422  3.015   34.509  1.00 13.94  ? 104 TRP H NE1 1 
ATOM   4078 C CE2 . TRP C 1 104 ? 21.371  3.314   35.338  1.00 13.84  ? 104 TRP H CE2 1 
ATOM   4079 C CE3 . TRP C 1 104 ? 20.466  5.257   36.447  1.00 12.90  ? 104 TRP H CE3 1 
ATOM   4080 C CZ2 . TRP C 1 104 ? 20.333  2.511   35.820  1.00 13.09  ? 104 TRP H CZ2 1 
ATOM   4081 C CZ3 . TRP C 1 104 ? 19.492  4.445   36.985  1.00 12.78  ? 104 TRP H CZ3 1 
ATOM   4082 C CH2 . TRP C 1 104 ? 19.414  3.093   36.657  1.00 12.55  ? 104 TRP H CH2 1 
ATOM   4083 N N   . GLY C 1 105 ? 21.997  9.552   34.107  1.00 15.22  ? 105 GLY H N   1 
ATOM   4084 C CA  . GLY C 1 105 ? 22.013  10.870  34.698  1.00 16.90  ? 105 GLY H CA  1 
ATOM   4085 C C   . GLY C 1 105 ? 22.486  10.799  36.148  1.00 17.26  ? 105 GLY H C   1 
ATOM   4086 O O   . GLY C 1 105 ? 22.608  9.705   36.703  1.00 17.94  ? 105 GLY H O   1 
ATOM   4087 N N   . GLN C 1 106 ? 22.786  11.972  36.730  1.00 17.51  ? 106 GLN H N   1 
ATOM   4088 C CA  . GLN C 1 106 ? 23.296  12.084  38.089  1.00 17.91  ? 106 GLN H CA  1 
ATOM   4089 C C   . GLN C 1 106 ? 22.161  11.938  39.111  1.00 16.83  ? 106 GLN H C   1 
ATOM   4090 O O   . GLN C 1 106 ? 22.421  11.741  40.298  1.00 17.95  ? 106 GLN H O   1 
ATOM   4091 C CB  . GLN C 1 106 ? 24.158  13.347  38.251  1.00 18.51  ? 106 GLN H CB  1 
ATOM   4092 C CG  . GLN C 1 106 ? 23.394  14.644  38.541  1.00 18.09  ? 106 GLN H CG  1 
ATOM   4093 C CD  . GLN C 1 106 ? 22.876  15.304  37.294  1.00 16.94  ? 106 GLN H CD  1 
ATOM   4094 O OE1 . GLN C 1 106 ? 22.839  14.734  36.204  1.00 14.44  ? 106 GLN H OE1 1 
ATOM   4095 N NE2 . GLN C 1 106 ? 22.465  16.548  37.442  1.00 17.60  ? 106 GLN H NE2 1 
ATOM   4096 N N   . GLY C 1 107 ? 20.913  11.904  38.637  1.00 16.40  ? 107 GLY H N   1 
ATOM   4097 C CA  . GLY C 1 107 ? 19.753  11.807  39.493  1.00 16.45  ? 107 GLY H CA  1 
ATOM   4098 C C   . GLY C 1 107 ? 19.222  13.193  39.877  1.00 17.14  ? 107 GLY H C   1 
ATOM   4099 O O   . GLY C 1 107 ? 19.998  14.117  40.074  1.00 15.62  ? 107 GLY H O   1 
ATOM   4100 N N   . THR C 1 108 ? 17.895  13.321  39.991  1.00 18.20  ? 108 THR H N   1 
ATOM   4101 C CA  . THR C 1 108 ? 17.247  14.542  40.473  1.00 18.01  ? 108 THR H CA  1 
ATOM   4102 C C   . THR C 1 108 ? 16.377  14.209  41.687  1.00 17.03  ? 108 THR H C   1 
ATOM   4103 O O   . THR C 1 108 ? 15.488  13.372  41.582  1.00 15.31  ? 108 THR H O   1 
ATOM   4104 C CB  . THR C 1 108 ? 16.342  15.142  39.400  1.00 19.49  ? 108 THR H CB  1 
ATOM   4105 O OG1 . THR C 1 108 ? 17.145  15.515  38.281  1.00 19.05  ? 108 THR H OG1 1 
ATOM   4106 C CG2 . THR C 1 108 ? 15.541  16.329  39.904  1.00 22.03  ? 108 THR H CG2 1 
ATOM   4107 N N   . LEU C 1 109 ? 16.690  14.804  42.842  1.00 16.02  ? 109 LEU H N   1 
ATOM   4108 C CA  . LEU C 1 109 ? 15.877  14.666  44.034  1.00 18.83  ? 109 LEU H CA  1 
ATOM   4109 C C   . LEU C 1 109 ? 14.646  15.563  43.890  1.00 19.91  ? 109 LEU H C   1 
ATOM   4110 O O   . LEU C 1 109 ? 14.801  16.758  43.618  1.00 20.92  ? 109 LEU H O   1 
ATOM   4111 C CB  . LEU C 1 109 ? 16.708  15.067  45.254  1.00 20.09  ? 109 LEU H CB  1 
ATOM   4112 C CG  . LEU C 1 109 ? 15.945  15.226  46.579  1.00 22.78  ? 109 LEU H CG  1 
ATOM   4113 C CD1 . LEU C 1 109 ? 15.219  13.946  46.966  1.00 23.27  ? 109 LEU H CD1 1 
ATOM   4114 C CD2 . LEU C 1 109 ? 16.885  15.672  47.717  1.00 21.42  ? 109 LEU H CD2 1 
ATOM   4115 N N   . VAL C 1 110 ? 13.463  14.948  43.963  1.00 18.45  ? 110 VAL H N   1 
ATOM   4116 C CA  . VAL C 1 110 ? 12.210  15.656  44.151  1.00 20.56  ? 110 VAL H CA  1 
ATOM   4117 C C   . VAL C 1 110 ? 11.740  15.383  45.573  1.00 19.87  ? 110 VAL H C   1 
ATOM   4118 O O   . VAL C 1 110 ? 11.552  14.239  45.952  1.00 21.13  ? 110 VAL H O   1 
ATOM   4119 C CB  . VAL C 1 110 ? 11.125  15.287  43.119  1.00 20.79  ? 110 VAL H CB  1 
ATOM   4120 C CG1 . VAL C 1 110 ? 9.898   16.189  43.279  1.00 21.96  ? 110 VAL H CG1 1 
ATOM   4121 C CG2 . VAL C 1 110 ? 11.618  15.398  41.681  1.00 21.66  ? 110 VAL H CG2 1 
ATOM   4122 N N   . THR C 1 111 ? 11.612  16.461  46.354  1.00 22.27  ? 111 THR H N   1 
ATOM   4123 C CA  . THR C 1 111 ? 11.073  16.423  47.700  1.00 23.69  ? 111 THR H CA  1 
ATOM   4124 C C   . THR C 1 111 ? 9.683   17.063  47.682  1.00 24.08  ? 111 THR H C   1 
ATOM   4125 O O   . THR C 1 111 ? 9.515   18.154  47.155  1.00 24.85  ? 111 THR H O   1 
ATOM   4126 C CB  . THR C 1 111 ? 11.975  17.195  48.673  1.00 23.50  ? 111 THR H CB  1 
ATOM   4127 O OG1 . THR C 1 111 ? 13.345  16.820  48.497  1.00 21.68  ? 111 THR H OG1 1 
ATOM   4128 C CG2 . THR C 1 111 ? 11.559  16.962  50.104  1.00 23.61  ? 111 THR H CG2 1 
ATOM   4129 N N   . VAL C 1 112 ? 8.685   16.341  48.184  1.00 25.84  ? 112 VAL H N   1 
ATOM   4130 C CA  . VAL C 1 112 ? 7.322   16.829  48.181  1.00 26.98  ? 112 VAL H CA  1 
ATOM   4131 C C   . VAL C 1 112 ? 6.996   17.185  49.623  1.00 28.07  ? 112 VAL H C   1 
ATOM   4132 O O   . VAL C 1 112 ? 6.901   16.302  50.467  1.00 27.16  ? 112 VAL H O   1 
ATOM   4133 C CB  . VAL C 1 112 ? 6.302   15.824  47.599  1.00 28.29  ? 112 VAL H CB  1 
ATOM   4134 C CG1 . VAL C 1 112 ? 4.873   16.363  47.690  1.00 27.66  ? 112 VAL H CG1 1 
ATOM   4135 C CG2 . VAL C 1 112 ? 6.622   15.466  46.152  1.00 26.61  ? 112 VAL H CG2 1 
ATOM   4136 N N   . SER C 1 113 ? 6.832   18.488  49.870  1.00 27.79  ? 113 SER H N   1 
ATOM   4137 C CA  . SER C 1 113 ? 6.687   19.004  51.217  1.00 30.94  ? 113 SER H CA  1 
ATOM   4138 C C   . SER C 1 113 ? 6.077   20.405  51.185  1.00 31.55  ? 113 SER H C   1 
ATOM   4139 O O   . SER C 1 113 ? 6.310   21.175  50.255  1.00 33.05  ? 113 SER H O   1 
ATOM   4140 C CB  . SER C 1 113 ? 8.024   19.016  51.911  1.00 30.78  ? 113 SER H CB  1 
ATOM   4141 O OG  . SER C 1 113 ? 7.942   19.736  53.122  1.00 31.87  ? 113 SER H OG  1 
ATOM   4142 N N   . SER C 1 114 ? 5.313   20.731  52.226  1.00 36.24  ? 114 SER H N   1 
ATOM   4143 C CA  . SER C 1 114 ? 4.783   22.072  52.398  1.00 39.83  ? 114 SER H CA  1 
ATOM   4144 C C   . SER C 1 114 ? 5.640   22.904  53.358  1.00 39.67  ? 114 SER H C   1 
ATOM   4145 O O   . SER C 1 114 ? 5.330   24.077  53.573  1.00 37.77  ? 114 SER H O   1 
ATOM   4146 C CB  . SER C 1 114 ? 3.360   21.989  52.869  1.00 44.01  ? 114 SER H CB  1 
ATOM   4147 O OG  . SER C 1 114 ? 3.262   21.079  53.948  1.00 47.98  ? 114 SER H OG  1 
ATOM   4148 N N   . ALA C 1 115 ? 6.727   22.326  53.905  1.00 35.77  ? 115 ALA H N   1 
ATOM   4149 C CA  . ALA C 1 115 ? 7.557   23.012  54.890  1.00 33.84  ? 115 ALA H CA  1 
ATOM   4150 C C   . ALA C 1 115 ? 8.324   24.183  54.269  1.00 35.74  ? 115 ALA H C   1 
ATOM   4151 O O   . ALA C 1 115 ? 8.501   24.244  53.057  1.00 35.73  ? 115 ALA H O   1 
ATOM   4152 C CB  . ALA C 1 115 ? 8.513   22.024  55.511  1.00 37.37  ? 115 ALA H CB  1 
ATOM   4153 N N   . SER C 1 116 ? 8.752   25.127  55.122  1.00 38.71  ? 116 SER H N   1 
ATOM   4154 C CA  . SER C 1 116 ? 9.521   26.301  54.722  1.00 39.64  ? 116 SER H CA  1 
ATOM   4155 C C   . SER C 1 116 ? 10.938  26.221  55.285  1.00 32.97  ? 116 SER H C   1 
ATOM   4156 O O   . SER C 1 116 ? 11.154  25.627  56.337  1.00 31.08  ? 116 SER H O   1 
ATOM   4157 C CB  . SER C 1 116 ? 8.861   27.578  55.199  1.00 43.42  ? 116 SER H CB  1 
ATOM   4158 O OG  . SER C 1 116 ? 7.554   27.702  54.660  1.00 54.20  ? 116 SER H OG  1 
ATOM   4159 N N   . THR C 1 117 ? 11.882  26.866  54.594  1.00 31.94  ? 117 THR H N   1 
ATOM   4160 C CA  . THR C 1 117 ? 13.265  26.944  55.045  1.00 36.80  ? 117 THR H CA  1 
ATOM   4161 C C   . THR C 1 117 ? 13.327  27.408  56.498  1.00 37.78  ? 117 THR H C   1 
ATOM   4162 O O   . THR C 1 117 ? 12.701  28.390  56.861  1.00 41.67  ? 117 THR H O   1 
ATOM   4163 C CB  . THR C 1 117 ? 14.098  27.930  54.215  1.00 36.38  ? 117 THR H CB  1 
ATOM   4164 O OG1 . THR C 1 117 ? 13.919  27.577  52.843  1.00 33.96  ? 117 THR H OG1 1 
ATOM   4165 C CG2 . THR C 1 117 ? 15.569  27.916  54.592  1.00 36.30  ? 117 THR H CG2 1 
ATOM   4166 N N   . LYS C 1 118 ? 14.119  26.714  57.318  1.00 40.15  ? 118 LYS H N   1 
ATOM   4167 C CA  . LYS C 1 118 ? 14.180  26.992  58.745  1.00 36.42  ? 118 LYS H CA  1 
ATOM   4168 C C   . LYS C 1 118 ? 15.469  26.390  59.298  1.00 30.02  ? 118 LYS H C   1 
ATOM   4169 O O   . LYS C 1 118 ? 15.707  25.196  59.126  1.00 29.82  ? 118 LYS H O   1 
ATOM   4170 C CB  . LYS C 1 118 ? 12.944  26.400  59.437  1.00 38.58  ? 118 LYS H CB  1 
ATOM   4171 C CG  . LYS C 1 118 ? 12.907  26.569  60.945  1.00 40.75  ? 118 LYS H CG  1 
ATOM   4172 C CD  . LYS C 1 118 ? 11.916  25.650  61.610  1.00 46.20  ? 118 LYS H CD  1 
ATOM   4173 C CE  . LYS C 1 118 ? 11.627  26.039  63.048  1.00 47.42  ? 118 LYS H CE  1 
ATOM   4174 N NZ  . LYS C 1 118 ? 12.787  25.792  63.939  1.00 50.31  ? 118 LYS H NZ  1 
ATOM   4175 N N   . GLY C 1 119 ? 16.281  27.230  59.947  1.00 27.57  ? 119 GLY H N   1 
ATOM   4176 C CA  . GLY C 1 119 ? 17.479  26.793  60.644  1.00 29.58  ? 119 GLY H CA  1 
ATOM   4177 C C   . GLY C 1 119 ? 17.149  25.940  61.873  1.00 33.33  ? 119 GLY H C   1 
ATOM   4178 O O   . GLY C 1 119 ? 16.088  26.095  62.458  1.00 30.06  ? 119 GLY H O   1 
ATOM   4179 N N   . PRO C 1 120 ? 18.060  25.039  62.315  1.00 34.48  ? 120 PRO H N   1 
ATOM   4180 C CA  . PRO C 1 120 ? 17.810  24.163  63.465  1.00 33.76  ? 120 PRO H CA  1 
ATOM   4181 C C   . PRO C 1 120 ? 18.077  24.796  64.831  1.00 37.34  ? 120 PRO H C   1 
ATOM   4182 O O   . PRO C 1 120 ? 18.736  25.833  64.913  1.00 33.89  ? 120 PRO H O   1 
ATOM   4183 C CB  . PRO C 1 120 ? 18.850  23.052  63.275  1.00 34.33  ? 120 PRO H CB  1 
ATOM   4184 C CG  . PRO C 1 120 ? 20.023  23.764  62.611  1.00 34.79  ? 120 PRO H CG  1 
ATOM   4185 C CD  . PRO C 1 120 ? 19.402  24.844  61.737  1.00 34.74  ? 120 PRO H CD  1 
ATOM   4186 N N   . SER C 1 121 ? 17.539  24.157  65.885  1.00 39.04  ? 121 SER H N   1 
ATOM   4187 C CA  . SER C 1 121 ? 17.972  24.355  67.262  1.00 40.02  ? 121 SER H CA  1 
ATOM   4188 C C   . SER C 1 121 ? 19.008  23.280  67.614  1.00 38.83  ? 121 SER H C   1 
ATOM   4189 O O   . SER C 1 121 ? 18.793  22.107  67.304  1.00 39.96  ? 121 SER H O   1 
ATOM   4190 C CB  . SER C 1 121 ? 16.800  24.268  68.220  1.00 46.20  ? 121 SER H CB  1 
ATOM   4191 O OG  . SER C 1 121 ? 15.768  25.192  67.894  1.00 55.30  ? 121 SER H OG  1 
ATOM   4192 N N   . VAL C 1 122 ? 20.098  23.670  68.295  1.00 30.31  ? 122 VAL H N   1 
ATOM   4193 C CA  . VAL C 1 122 ? 21.122  22.733  68.707  1.00 29.46  ? 122 VAL H CA  1 
ATOM   4194 C C   . VAL C 1 122 ? 21.080  22.625  70.230  1.00 31.57  ? 122 VAL H C   1 
ATOM   4195 O O   . VAL C 1 122 ? 21.153  23.630  70.937  1.00 34.03  ? 122 VAL H O   1 
ATOM   4196 C CB  . VAL C 1 122 ? 22.511  23.154  68.190  1.00 29.05  ? 122 VAL H CB  1 
ATOM   4197 C CG1 . VAL C 1 122 ? 23.576  22.144  68.571  1.00 26.84  ? 122 VAL H CG1 1 
ATOM   4198 C CG2 . VAL C 1 122 ? 22.520  23.364  66.683  1.00 32.04  ? 122 VAL H CG2 1 
ATOM   4199 N N   . PHE C 1 123 ? 20.908  21.395  70.723  1.00 33.36  ? 123 PHE H N   1 
ATOM   4200 C CA  . PHE C 1 123 ? 20.786  21.130  72.150  1.00 32.75  ? 123 PHE H CA  1 
ATOM   4201 C C   . PHE C 1 123 ? 21.885  20.155  72.554  1.00 32.11  ? 123 PHE H C   1 
ATOM   4202 O O   . PHE C 1 123 ? 22.243  19.276  71.778  1.00 27.03  ? 123 PHE H O   1 
ATOM   4203 C CB  . PHE C 1 123 ? 19.398  20.589  72.506  1.00 32.31  ? 123 PHE H CB  1 
ATOM   4204 C CG  . PHE C 1 123 ? 18.272  21.520  72.123  1.00 34.40  ? 123 PHE H CG  1 
ATOM   4205 C CD1 . PHE C 1 123 ? 18.245  22.826  72.586  1.00 32.67  ? 123 PHE H CD1 1 
ATOM   4206 C CD2 . PHE C 1 123 ? 17.249  21.096  71.287  1.00 34.05  ? 123 PHE H CD2 1 
ATOM   4207 C CE1 . PHE C 1 123 ? 17.240  23.691  72.188  1.00 34.41  ? 123 PHE H CE1 1 
ATOM   4208 C CE2 . PHE C 1 123 ? 16.225  21.953  70.916  1.00 28.69  ? 123 PHE H CE2 1 
ATOM   4209 C CZ  . PHE C 1 123 ? 16.224  23.249  71.366  1.00 33.10  ? 123 PHE H CZ  1 
ATOM   4210 N N   . PRO C 1 124 ? 22.475  20.293  73.767  1.00 32.60  ? 124 PRO H N   1 
ATOM   4211 C CA  . PRO C 1 124 ? 23.579  19.423  74.174  1.00 33.15  ? 124 PRO H CA  1 
ATOM   4212 C C   . PRO C 1 124 ? 23.032  18.046  74.553  1.00 33.47  ? 124 PRO H C   1 
ATOM   4213 O O   . PRO C 1 124 ? 21.885  17.954  74.973  1.00 33.33  ? 124 PRO H O   1 
ATOM   4214 C CB  . PRO C 1 124 ? 24.200  20.197  75.342  1.00 33.07  ? 124 PRO H CB  1 
ATOM   4215 C CG  . PRO C 1 124 ? 23.013  20.919  75.970  1.00 33.71  ? 124 PRO H CG  1 
ATOM   4216 C CD  . PRO C 1 124 ? 22.106  21.271  74.802  1.00 32.48  ? 124 PRO H CD  1 
ATOM   4217 N N   . LEU C 1 125 ? 23.821  16.990  74.283  1.00 35.12  ? 125 LEU H N   1 
ATOM   4218 C CA  . LEU C 1 125 ? 23.654  15.666  74.873  1.00 36.44  ? 125 LEU H CA  1 
ATOM   4219 C C   . LEU C 1 125 ? 24.820  15.484  75.849  1.00 38.27  ? 125 LEU H C   1 
ATOM   4220 O O   . LEU C 1 125 ? 25.947  15.158  75.450  1.00 33.17  ? 125 LEU H O   1 
ATOM   4221 C CB  . LEU C 1 125 ? 23.657  14.579  73.780  1.00 35.70  ? 125 LEU H CB  1 
ATOM   4222 C CG  . LEU C 1 125 ? 22.573  14.680  72.695  1.00 36.07  ? 125 LEU H CG  1 
ATOM   4223 C CD1 . LEU C 1 125 ? 22.669  13.538  71.692  1.00 33.41  ? 125 LEU H CD1 1 
ATOM   4224 C CD2 . LEU C 1 125 ? 21.168  14.723  73.289  1.00 34.81  ? 125 LEU H CD2 1 
ATOM   4225 N N   . ALA C 1 126 ? 24.557  15.780  77.124  1.00 40.07  ? 126 ALA H N   1 
ATOM   4226 C CA  . ALA C 1 126 ? 25.616  15.981  78.103  1.00 44.10  ? 126 ALA H CA  1 
ATOM   4227 C C   . ALA C 1 126 ? 26.115  14.635  78.619  1.00 40.92  ? 126 ALA H C   1 
ATOM   4228 O O   . ALA C 1 126 ? 25.324  13.757  78.952  1.00 41.73  ? 126 ALA H O   1 
ATOM   4229 C CB  . ALA C 1 126 ? 25.109  16.839  79.234  1.00 46.39  ? 126 ALA H CB  1 
ATOM   4230 N N   . PRO C 1 127 ? 27.445  14.441  78.736  1.00 42.29  ? 127 PRO H N   1 
ATOM   4231 C CA  . PRO C 1 127 ? 27.988  13.195  79.271  1.00 43.39  ? 127 PRO H CA  1 
ATOM   4232 C C   . PRO C 1 127 ? 27.543  13.028  80.716  1.00 50.38  ? 127 PRO H C   1 
ATOM   4233 O O   . PRO C 1 127 ? 27.401  14.027  81.420  1.00 49.89  ? 127 PRO H O   1 
ATOM   4234 C CB  . PRO C 1 127 ? 29.506  13.387  79.203  1.00 41.04  ? 127 PRO H CB  1 
ATOM   4235 C CG  . PRO C 1 127 ? 29.689  14.885  79.210  1.00 41.50  ? 127 PRO H CG  1 
ATOM   4236 C CD  . PRO C 1 127 ? 28.490  15.438  78.459  1.00 41.98  ? 127 PRO H CD  1 
ATOM   4237 N N   . SER C 1 128 ? 27.306  11.780  81.139  1.00 61.29  ? 128 SER H N   1 
ATOM   4238 C CA  . SER C 1 128 ? 26.859  11.510  82.501  1.00 68.47  ? 128 SER H CA  1 
ATOM   4239 C C   . SER C 1 128 ? 28.079  11.294  83.396  1.00 78.61  ? 128 SER H C   1 
ATOM   4240 O O   . SER C 1 128 ? 29.105  10.767  82.961  1.00 77.17  ? 128 SER H O   1 
ATOM   4241 C CB  . SER C 1 128 ? 25.866  10.353  82.568  1.00 63.99  ? 128 SER H CB  1 
ATOM   4242 O OG  . SER C 1 128 ? 26.509  9.100   82.746  1.00 61.57  ? 128 SER H OG  1 
ATOM   4243 N N   . SER C 1 129 ? 27.964  11.762  84.644  1.00 90.22  ? 129 SER H N   1 
ATOM   4244 C CA  . SER C 1 129 ? 28.975  11.528  85.665  1.00 89.49  ? 129 SER H CA  1 
ATOM   4245 C C   . SER C 1 129 ? 29.080  10.029  85.944  1.00 88.81  ? 129 SER H C   1 
ATOM   4246 O O   . SER C 1 129 ? 30.180  9.494   86.095  1.00 83.93  ? 129 SER H O   1 
ATOM   4247 C CB  . SER C 1 129 ? 28.660  12.323  86.916  1.00 87.62  ? 129 SER H CB  1 
ATOM   4248 O OG  . SER C 1 129 ? 27.258  12.372  87.152  1.00 79.92  ? 129 SER H OG  1 
ATOM   4249 N N   . LYS C 1 130 ? 27.912  9.372   85.945  1.00 88.20  ? 130 LYS H N   1 
ATOM   4250 C CA  . LYS C 1 130 ? 27.762  7.957   86.248  1.00 91.87  ? 130 LYS H CA  1 
ATOM   4251 C C   . LYS C 1 130 ? 28.873  7.174   85.546  1.00 98.20  ? 130 LYS H C   1 
ATOM   4252 O O   . LYS C 1 130 ? 28.768  6.855   84.362  1.00 96.39  ? 130 LYS H O   1 
ATOM   4253 C CB  . LYS C 1 130 ? 26.351  7.513   85.843  1.00 88.28  ? 130 LYS H CB  1 
ATOM   4254 C CG  . LYS C 1 130 ? 25.229  8.418   86.349  1.00 91.64  ? 130 LYS H CG  1 
ATOM   4255 C CD  . LYS C 1 130 ? 24.552  7.970   87.633  1.00 88.51  ? 130 LYS H CD  1 
ATOM   4256 C CE  . LYS C 1 130 ? 23.137  7.477   87.411  1.00 84.83  ? 130 LYS H CE  1 
ATOM   4257 N NZ  . LYS C 1 130 ? 23.074  6.414   86.380  1.00 82.83  ? 130 LYS H NZ  1 
ATOM   4258 N N   . SER C 1 131 ? 29.947  6.893   86.301  1.00 99.77  ? 131 SER H N   1 
ATOM   4259 C CA  . SER C 1 131 ? 31.180  6.341   85.764  1.00 94.40  ? 131 SER H CA  1 
ATOM   4260 C C   . SER C 1 131 ? 31.684  7.225   84.615  1.00 91.81  ? 131 SER H C   1 
ATOM   4261 O O   . SER C 1 131 ? 32.732  6.879   84.043  1.00 92.93  ? 131 SER H O   1 
ATOM   4262 C CB  . SER C 1 131 ? 30.995  4.910   85.335  1.00 93.64  ? 131 SER H CB  1 
ATOM   4263 O OG  . SER C 1 131 ? 32.164  4.424   84.693  1.00 100.34 ? 131 SER H OG  1 
ATOM   4264 N N   . GLY C 1 135 ? 36.162  3.911   81.486  1.00 63.35  ? 135 GLY H N   1 
ATOM   4265 C CA  . GLY C 1 135 ? 37.174  4.391   80.527  1.00 59.73  ? 135 GLY H CA  1 
ATOM   4266 C C   . GLY C 1 135 ? 36.592  5.348   79.485  1.00 58.02  ? 135 GLY H C   1 
ATOM   4267 O O   . GLY C 1 135 ? 37.214  6.375   79.209  1.00 54.35  ? 135 GLY H O   1 
ATOM   4268 N N   . THR C 1 136 ? 35.410  5.010   78.929  1.00 51.77  ? 136 THR H N   1 
ATOM   4269 C CA  . THR C 1 136 ? 34.827  5.720   77.793  1.00 47.38  ? 136 THR H CA  1 
ATOM   4270 C C   . THR C 1 136 ? 33.484  6.366   78.127  1.00 40.38  ? 136 THR H C   1 
ATOM   4271 O O   . THR C 1 136 ? 32.538  5.682   78.492  1.00 39.76  ? 136 THR H O   1 
ATOM   4272 C CB  . THR C 1 136 ? 34.565  4.784   76.609  1.00 49.50  ? 136 THR H CB  1 
ATOM   4273 O OG1 . THR C 1 136 ? 35.768  4.048   76.413  1.00 60.20  ? 136 THR H OG1 1 
ATOM   4274 C CG2 . THR C 1 136 ? 34.191  5.511   75.335  1.00 45.96  ? 136 THR H CG2 1 
ATOM   4275 N N   . ALA C 1 137 ? 33.398  7.688   77.945  1.00 33.43  ? 137 ALA H N   1 
ATOM   4276 C CA  . ALA C 1 137 ? 32.152  8.425   78.079  1.00 28.82  ? 137 ALA H CA  1 
ATOM   4277 C C   . ALA C 1 137 ? 31.588  8.688   76.686  1.00 29.92  ? 137 ALA H C   1 
ATOM   4278 O O   . ALA C 1 137 ? 32.319  8.580   75.697  1.00 33.04  ? 137 ALA H O   1 
ATOM   4279 C CB  . ALA C 1 137 ? 32.414  9.715   78.794  1.00 25.98  ? 137 ALA H CB  1 
ATOM   4280 N N   . ALA C 1 138 ? 30.312  9.074   76.611  1.00 27.18  ? 138 ALA H N   1 
ATOM   4281 C CA  . ALA C 1 138 ? 29.741  9.502   75.344  1.00 27.46  ? 138 ALA H CA  1 
ATOM   4282 C C   . ALA C 1 138 ? 29.052  10.839  75.528  1.00 26.47  ? 138 ALA H C   1 
ATOM   4283 O O   . ALA C 1 138 ? 28.480  11.102  76.574  1.00 27.59  ? 138 ALA H O   1 
ATOM   4284 C CB  . ALA C 1 138 ? 28.780  8.475   74.812  1.00 28.06  ? 138 ALA H CB  1 
ATOM   4285 N N   . LEU C 1 139 ? 29.154  11.701  74.520  1.00 27.22  ? 139 LEU H N   1 
ATOM   4286 C CA  . LEU C 1 139 ? 28.426  12.952  74.564  1.00 30.71  ? 139 LEU H CA  1 
ATOM   4287 C C   . LEU C 1 139 ? 27.999  13.270  73.140  1.00 26.46  ? 139 LEU H C   1 
ATOM   4288 O O   . LEU C 1 139 ? 28.412  12.571  72.223  1.00 26.87  ? 139 LEU H O   1 
ATOM   4289 C CB  . LEU C 1 139 ? 29.303  14.040  75.209  1.00 32.25  ? 139 LEU H CB  1 
ATOM   4290 C CG  . LEU C 1 139 ? 30.689  14.253  74.604  1.00 37.05  ? 139 LEU H CG  1 
ATOM   4291 C CD1 . LEU C 1 139 ? 30.605  15.002  73.293  1.00 39.90  ? 139 LEU H CD1 1 
ATOM   4292 C CD2 . LEU C 1 139 ? 31.591  15.021  75.552  1.00 40.42  ? 139 LEU H CD2 1 
ATOM   4293 N N   . GLY C 1 140 ? 27.205  14.328  72.960  1.00 26.99  ? 140 GLY H N   1 
ATOM   4294 C CA  . GLY C 1 140 ? 26.824  14.733  71.619  1.00 29.59  ? 140 GLY H CA  1 
ATOM   4295 C C   . GLY C 1 140 ? 26.030  16.033  71.567  1.00 30.58  ? 140 GLY H C   1 
ATOM   4296 O O   . GLY C 1 140 ? 25.993  16.772  72.542  1.00 32.19  ? 140 GLY H O   1 
ATOM   4297 N N   . CYS C 1 141 ? 25.482  16.300  70.371  1.00 29.69  ? 141 CYS H N   1 
ATOM   4298 C CA  . CYS C 1 141 ? 24.597  17.410  70.068  1.00 30.41  ? 141 CYS H CA  1 
ATOM   4299 C C   . CYS C 1 141 ? 23.373  16.863  69.343  1.00 34.88  ? 141 CYS H C   1 
ATOM   4300 O O   . CYS C 1 141 ? 23.475  15.922  68.549  1.00 34.99  ? 141 CYS H O   1 
ATOM   4301 C CB  . CYS C 1 141 ? 25.248  18.449  69.163  1.00 31.90  ? 141 CYS H CB  1 
ATOM   4302 S SG  . CYS C 1 141 ? 26.363  19.560  70.062  1.00 42.84  ? 141 CYS H SG  1 
ATOM   4303 N N   . LEU C 1 142 ? 22.229  17.502  69.604  1.00 34.95  ? 142 LEU H N   1 
ATOM   4304 C CA  . LEU C 1 142 ? 20.954  17.134  69.018  1.00 37.47  ? 142 LEU H CA  1 
ATOM   4305 C C   . LEU C 1 142 ? 20.470  18.302  68.172  1.00 35.75  ? 142 LEU H C   1 
ATOM   4306 O O   . LEU C 1 142 ? 20.337  19.415  68.680  1.00 32.30  ? 142 LEU H O   1 
ATOM   4307 C CB  . LEU C 1 142 ? 19.970  16.804  70.148  1.00 39.70  ? 142 LEU H CB  1 
ATOM   4308 C CG  . LEU C 1 142 ? 18.505  16.643  69.742  1.00 45.08  ? 142 LEU H CG  1 
ATOM   4309 C CD1 . LEU C 1 142 ? 18.334  15.625  68.611  1.00 43.40  ? 142 LEU H CD1 1 
ATOM   4310 C CD2 . LEU C 1 142 ? 17.661  16.238  70.947  1.00 46.03  ? 142 LEU H CD2 1 
ATOM   4311 N N   . VAL C 1 143 ? 20.246  18.039  66.879  1.00 35.43  ? 143 VAL H N   1 
ATOM   4312 C CA  . VAL C 1 143 ? 20.008  19.094  65.913  1.00 35.87  ? 143 VAL H CA  1 
ATOM   4313 C C   . VAL C 1 143 ? 18.587  18.957  65.384  1.00 40.27  ? 143 VAL H C   1 
ATOM   4314 O O   . VAL C 1 143 ? 18.315  18.047  64.608  1.00 42.63  ? 143 VAL H O   1 
ATOM   4315 C CB  . VAL C 1 143 ? 21.026  19.028  64.767  1.00 37.26  ? 143 VAL H CB  1 
ATOM   4316 C CG1 . VAL C 1 143 ? 20.781  20.139  63.748  1.00 35.55  ? 143 VAL H CG1 1 
ATOM   4317 C CG2 . VAL C 1 143 ? 22.462  19.059  65.288  1.00 38.11  ? 143 VAL H CG2 1 
ATOM   4318 N N   . LYS C 1 144 ? 17.709  19.893  65.772  1.00 41.65  ? 144 LYS H N   1 
ATOM   4319 C CA  . LYS C 1 144 ? 16.277  19.644  65.708  1.00 43.87  ? 144 LYS H CA  1 
ATOM   4320 C C   . LYS C 1 144 ? 15.578  20.721  64.876  1.00 36.72  ? 144 LYS H C   1 
ATOM   4321 O O   . LYS C 1 144 ? 15.974  21.895  64.883  1.00 33.61  ? 144 LYS H O   1 
ATOM   4322 C CB  . LYS C 1 144 ? 15.713  19.544  67.129  1.00 43.55  ? 144 LYS H CB  1 
ATOM   4323 C CG  . LYS C 1 144 ? 14.588  18.533  67.285  1.00 47.89  ? 144 LYS H CG  1 
ATOM   4324 C CD  . LYS C 1 144 ? 13.985  18.477  68.681  1.00 48.49  ? 144 LYS H CD  1 
ATOM   4325 C CE  . LYS C 1 144 ? 12.732  17.630  68.743  1.00 50.42  ? 144 LYS H CE  1 
ATOM   4326 N NZ  . LYS C 1 144 ? 11.691  18.141  67.821  1.00 54.29  ? 144 LYS H NZ  1 
ATOM   4327 N N   . ASP C 1 145 ? 14.571  20.265  64.112  1.00 34.44  ? 145 ASP H N   1 
ATOM   4328 C CA  . ASP C 1 145 ? 13.602  21.115  63.426  1.00 31.93  ? 145 ASP H CA  1 
ATOM   4329 C C   . ASP C 1 145 ? 14.277  22.031  62.403  1.00 33.07  ? 145 ASP H C   1 
ATOM   4330 O O   . ASP C 1 145 ? 14.242  23.263  62.540  1.00 34.64  ? 145 ASP H O   1 
ATOM   4331 C CB  . ASP C 1 145 ? 12.788  21.959  64.412  1.00 30.10  ? 145 ASP H CB  1 
ATOM   4332 C CG  . ASP C 1 145 ? 12.015  21.163  65.450  1.00 32.49  ? 145 ASP H CG  1 
ATOM   4333 O OD1 . ASP C 1 145 ? 11.804  19.946  65.233  1.00 30.41  ? 145 ASP H OD1 1 
ATOM   4334 O OD2 . ASP C 1 145 ? 11.702  21.762  66.511  1.00 35.94  ? 145 ASP H OD2 1 
ATOM   4335 N N   . TYR C 1 146 ? 14.836  21.434  61.342  1.00 29.96  ? 146 TYR H N   1 
ATOM   4336 C CA  . TYR C 1 146 ? 15.331  22.229  60.229  1.00 30.98  ? 146 TYR H CA  1 
ATOM   4337 C C   . TYR C 1 146 ? 14.661  21.784  58.932  1.00 28.52  ? 146 TYR H C   1 
ATOM   4338 O O   . TYR C 1 146 ? 14.154  20.671  58.828  1.00 27.58  ? 146 TYR H O   1 
ATOM   4339 C CB  . TYR C 1 146 ? 16.863  22.152  60.113  1.00 30.78  ? 146 TYR H CB  1 
ATOM   4340 C CG  . TYR C 1 146 ? 17.452  20.768  59.937  1.00 28.61  ? 146 TYR H CG  1 
ATOM   4341 C CD1 . TYR C 1 146 ? 17.576  19.900  61.009  1.00 30.05  ? 146 TYR H CD1 1 
ATOM   4342 C CD2 . TYR C 1 146 ? 17.890  20.326  58.701  1.00 27.79  ? 146 TYR H CD2 1 
ATOM   4343 C CE1 . TYR C 1 146 ? 18.136  18.640  60.868  1.00 30.97  ? 146 TYR H CE1 1 
ATOM   4344 C CE2 . TYR C 1 146 ? 18.438  19.063  58.533  1.00 27.63  ? 146 TYR H CE2 1 
ATOM   4345 C CZ  . TYR C 1 146 ? 18.580  18.227  59.627  1.00 28.57  ? 146 TYR H CZ  1 
ATOM   4346 O OH  . TYR C 1 146 ? 19.113  16.987  59.503  1.00 30.98  ? 146 TYR H OH  1 
ATOM   4347 N N   . PHE C 1 147 ? 14.678  22.672  57.937  1.00 28.29  ? 147 PHE H N   1 
ATOM   4348 C CA  . PHE C 1 147 ? 14.320  22.279  56.582  1.00 29.02  ? 147 PHE H CA  1 
ATOM   4349 C C   . PHE C 1 147 ? 14.952  23.241  55.573  1.00 24.60  ? 147 PHE H C   1 
ATOM   4350 O O   . PHE C 1 147 ? 15.142  24.407  55.909  1.00 24.91  ? 147 PHE H O   1 
ATOM   4351 C CB  . PHE C 1 147 ? 12.801  22.289  56.474  1.00 31.98  ? 147 PHE H CB  1 
ATOM   4352 C CG  . PHE C 1 147 ? 12.287  21.738  55.174  1.00 33.54  ? 147 PHE H CG  1 
ATOM   4353 C CD1 . PHE C 1 147 ? 12.068  20.378  55.029  1.00 33.69  ? 147 PHE H CD1 1 
ATOM   4354 C CD2 . PHE C 1 147 ? 12.054  22.579  54.097  1.00 36.18  ? 147 PHE H CD2 1 
ATOM   4355 C CE1 . PHE C 1 147 ? 11.603  19.863  53.834  1.00 32.65  ? 147 PHE H CE1 1 
ATOM   4356 C CE2 . PHE C 1 147 ? 11.580  22.058  52.903  1.00 38.18  ? 147 PHE H CE2 1 
ATOM   4357 C CZ  . PHE C 1 147 ? 11.383  20.702  52.770  1.00 33.72  ? 147 PHE H CZ  1 
ATOM   4358 N N   . PRO C 1 148 ? 15.344  22.844  54.334  1.00 25.14  ? 148 PRO H N   1 
ATOM   4359 C CA  . PRO C 1 148 ? 15.462  21.446  53.889  1.00 26.93  ? 148 PRO H CA  1 
ATOM   4360 C C   . PRO C 1 148 ? 16.756  20.786  54.368  1.00 25.63  ? 148 PRO H C   1 
ATOM   4361 O O   . PRO C 1 148 ? 17.513  21.385  55.111  1.00 25.64  ? 148 PRO H O   1 
ATOM   4362 C CB  . PRO C 1 148 ? 15.530  21.564  52.361  1.00 27.12  ? 148 PRO H CB  1 
ATOM   4363 C CG  . PRO C 1 148 ? 16.241  22.897  52.118  1.00 27.52  ? 148 PRO H CG  1 
ATOM   4364 C CD  . PRO C 1 148 ? 15.760  23.779  53.266  1.00 27.09  ? 148 PRO H CD  1 
ATOM   4365 N N   . GLU C 1 149 ? 16.982  19.536  53.973  1.00 26.17  ? 149 GLU H N   1 
ATOM   4366 C CA  . GLU C 1 149 ? 18.281  18.929  54.179  1.00 29.50  ? 149 GLU H CA  1 
ATOM   4367 C C   . GLU C 1 149 ? 19.286  19.579  53.229  1.00 30.62  ? 149 GLU H C   1 
ATOM   4368 O O   . GLU C 1 149 ? 18.904  20.128  52.203  1.00 33.02  ? 149 GLU H O   1 
ATOM   4369 C CB  . GLU C 1 149 ? 18.167  17.426  53.959  1.00 31.59  ? 149 GLU H CB  1 
ATOM   4370 C CG  . GLU C 1 149 ? 17.233  16.750  54.956  1.00 35.55  ? 149 GLU H CG  1 
ATOM   4371 C CD  . GLU C 1 149 ? 17.535  15.267  55.110  1.00 43.32  ? 149 GLU H CD  1 
ATOM   4372 O OE1 . GLU C 1 149 ? 18.589  14.942  55.721  1.00 40.71  ? 149 GLU H OE1 1 
ATOM   4373 O OE2 . GLU C 1 149 ? 16.752  14.439  54.575  1.00 48.62  ? 149 GLU H OE2 1 
ATOM   4374 N N   . PRO C 1 150 ? 20.605  19.563  53.525  1.00 28.91  ? 150 PRO H N   1 
ATOM   4375 C CA  . PRO C 1 150 ? 21.142  18.987  54.760  1.00 29.02  ? 150 PRO H CA  1 
ATOM   4376 C C   . PRO C 1 150 ? 21.650  19.989  55.807  1.00 27.40  ? 150 PRO H C   1 
ATOM   4377 O O   . PRO C 1 150 ? 21.900  21.163  55.516  1.00 21.02  ? 150 PRO H O   1 
ATOM   4378 C CB  . PRO C 1 150 ? 22.347  18.226  54.164  1.00 26.44  ? 150 PRO H CB  1 
ATOM   4379 C CG  . PRO C 1 150 ? 22.915  19.251  53.165  1.00 27.50  ? 150 PRO H CG  1 
ATOM   4380 C CD  . PRO C 1 150 ? 21.689  19.987  52.610  1.00 28.14  ? 150 PRO H CD  1 
ATOM   4381 N N   . VAL C 1 151 ? 21.855  19.476  57.022  1.00 28.12  ? 151 VAL H N   1 
ATOM   4382 C CA  . VAL C 1 151 ? 22.767  20.100  57.968  1.00 33.17  ? 151 VAL H CA  1 
ATOM   4383 C C   . VAL C 1 151 ? 24.112  19.350  57.982  1.00 34.80  ? 151 VAL H C   1 
ATOM   4384 O O   . VAL C 1 151 ? 24.138  18.146  57.759  1.00 36.55  ? 151 VAL H O   1 
ATOM   4385 C CB  . VAL C 1 151 ? 22.081  20.117  59.338  1.00 35.15  ? 151 VAL H CB  1 
ATOM   4386 C CG1 . VAL C 1 151 ? 22.369  18.847  60.118  1.00 33.16  ? 151 VAL H CG1 1 
ATOM   4387 C CG2 . VAL C 1 151 ? 22.457  21.365  60.108  1.00 41.06  ? 151 VAL H CG2 1 
ATOM   4388 N N   . THR C 1 152 ? 25.235  20.069  58.176  1.00 34.14  ? 152 THR H N   1 
ATOM   4389 C CA  . THR C 1 152 ? 26.540  19.468  58.403  1.00 32.60  ? 152 THR H CA  1 
ATOM   4390 C C   . THR C 1 152 ? 26.972  19.692  59.857  1.00 32.92  ? 152 THR H C   1 
ATOM   4391 O O   . THR C 1 152 ? 26.654  20.715  60.473  1.00 31.52  ? 152 THR H O   1 
ATOM   4392 C CB  . THR C 1 152 ? 27.634  19.975  57.438  1.00 34.64  ? 152 THR H CB  1 
ATOM   4393 O OG1 . THR C 1 152 ? 27.943  21.350  57.667  1.00 33.37  ? 152 THR H OG1 1 
ATOM   4394 C CG2 . THR C 1 152 ? 27.293  19.772  55.976  1.00 33.44  ? 152 THR H CG2 1 
ATOM   4395 N N   . VAL C 1 153 ? 27.715  18.718  60.401  1.00 27.51  ? 153 VAL H N   1 
ATOM   4396 C CA  . VAL C 1 153 ? 28.172  18.784  61.780  1.00 28.75  ? 153 VAL H CA  1 
ATOM   4397 C C   . VAL C 1 153 ? 29.642  18.403  61.841  1.00 26.75  ? 153 VAL H C   1 
ATOM   4398 O O   . VAL C 1 153 ? 30.010  17.363  61.321  1.00 26.40  ? 153 VAL H O   1 
ATOM   4399 C CB  . VAL C 1 153 ? 27.399  17.834  62.702  1.00 27.19  ? 153 VAL H CB  1 
ATOM   4400 C CG1 . VAL C 1 153 ? 27.939  17.936  64.117  1.00 28.18  ? 153 VAL H CG1 1 
ATOM   4401 C CG2 . VAL C 1 153 ? 25.904  18.080  62.659  1.00 27.60  ? 153 VAL H CG2 1 
ATOM   4402 N N   . SER C 1 154 ? 30.436  19.205  62.545  1.00 26.89  ? 154 SER H N   1 
ATOM   4403 C CA  . SER C 1 154 ? 31.788  18.803  62.908  1.00 29.90  ? 154 SER H CA  1 
ATOM   4404 C C   . SER C 1 154 ? 31.966  18.954  64.417  1.00 25.51  ? 154 SER H C   1 
ATOM   4405 O O   . SER C 1 154 ? 31.087  19.476  65.104  1.00 22.67  ? 154 SER H O   1 
ATOM   4406 C CB  . SER C 1 154 ? 32.835  19.578  62.121  1.00 30.85  ? 154 SER H CB  1 
ATOM   4407 O OG  . SER C 1 154 ? 32.795  20.953  62.460  1.00 37.10  ? 154 SER H OG  1 
ATOM   4408 N N   . TRP C 1 155 ? 33.085  18.440  64.936  1.00 23.90  ? 155 TRP H N   1 
ATOM   4409 C CA  . TRP C 1 155 ? 33.423  18.677  66.331  1.00 23.25  ? 155 TRP H CA  1 
ATOM   4410 C C   . TRP C 1 155 ? 34.770  19.403  66.424  1.00 22.38  ? 155 TRP H C   1 
ATOM   4411 O O   . TRP C 1 155 ? 35.737  19.068  65.723  1.00 22.17  ? 155 TRP H O   1 
ATOM   4412 C CB  . TRP C 1 155 ? 33.399  17.371  67.125  1.00 21.45  ? 155 TRP H CB  1 
ATOM   4413 C CG  . TRP C 1 155 ? 32.020  16.833  67.348  1.00 23.53  ? 155 TRP H CG  1 
ATOM   4414 C CD1 . TRP C 1 155 ? 31.284  16.053  66.498  1.00 22.93  ? 155 TRP H CD1 1 
ATOM   4415 C CD2 . TRP C 1 155 ? 31.185  17.049  68.497  1.00 21.55  ? 155 TRP H CD2 1 
ATOM   4416 N NE1 . TRP C 1 155 ? 30.058  15.770  67.040  1.00 21.54  ? 155 TRP H NE1 1 
ATOM   4417 C CE2 . TRP C 1 155 ? 29.988  16.335  68.284  1.00 22.25  ? 155 TRP H CE2 1 
ATOM   4418 C CE3 . TRP C 1 155 ? 31.362  17.715  69.705  1.00 22.80  ? 155 TRP H CE3 1 
ATOM   4419 C CZ2 . TRP C 1 155 ? 28.952  16.327  69.212  1.00 24.16  ? 155 TRP H CZ2 1 
ATOM   4420 C CZ3 . TRP C 1 155 ? 30.344  17.701  70.630  1.00 25.26  ? 155 TRP H CZ3 1 
ATOM   4421 C CH2 . TRP C 1 155 ? 29.141  17.044  70.372  1.00 25.18  ? 155 TRP H CH2 1 
ATOM   4422 N N   . ASN C 1 156 ? 34.819  20.390  67.320  1.00 22.29  ? 156 ASN H N   1 
ATOM   4423 C CA  . ASN C 1 156 ? 36.021  21.177  67.569  1.00 23.07  ? 156 ASN H CA  1 
ATOM   4424 C C   . ASN C 1 156 ? 36.646  21.626  66.255  1.00 22.93  ? 156 ASN H C   1 
ATOM   4425 O O   . ASN C 1 156 ? 37.824  21.395  66.026  1.00 29.06  ? 156 ASN H O   1 
ATOM   4426 C CB  . ASN C 1 156 ? 36.996  20.370  68.435  1.00 21.10  ? 156 ASN H CB  1 
ATOM   4427 C CG  . ASN C 1 156 ? 36.394  20.126  69.798  1.00 20.64  ? 156 ASN H CG  1 
ATOM   4428 O OD1 . ASN C 1 156 ? 35.393  20.765  70.133  1.00 18.74  ? 156 ASN H OD1 1 
ATOM   4429 N ND2 . ASN C 1 156 ? 37.009  19.268  70.604  1.00 19.78  ? 156 ASN H ND2 1 
ATOM   4430 N N   . SER C 1 157 ? 35.816  22.168  65.363  1.00 25.80  ? 157 SER H N   1 
ATOM   4431 C CA  . SER C 1 157 ? 36.237  22.665  64.059  1.00 26.36  ? 157 SER H CA  1 
ATOM   4432 C C   . SER C 1 157 ? 36.990  21.605  63.257  1.00 26.66  ? 157 SER H C   1 
ATOM   4433 O O   . SER C 1 157 ? 37.884  21.917  62.473  1.00 30.63  ? 157 SER H O   1 
ATOM   4434 C CB  . SER C 1 157 ? 37.034  23.929  64.238  1.00 27.15  ? 157 SER H CB  1 
ATOM   4435 O OG  . SER C 1 157 ? 36.256  24.849  64.988  1.00 29.91  ? 157 SER H OG  1 
ATOM   4436 N N   . GLY C 1 158 ? 36.587  20.342  63.396  1.00 25.58  ? 158 GLY H N   1 
ATOM   4437 C CA  . GLY C 1 158 ? 37.116  19.301  62.529  1.00 24.48  ? 158 GLY H CA  1 
ATOM   4438 C C   . GLY C 1 158 ? 38.368  18.654  63.112  1.00 22.67  ? 158 GLY H C   1 
ATOM   4439 O O   . GLY C 1 158 ? 38.899  17.739  62.508  1.00 24.43  ? 158 GLY H O   1 
ATOM   4440 N N   . ALA C 1 159 ? 38.786  19.105  64.303  1.00 21.68  ? 159 ALA H N   1 
ATOM   4441 C CA  . ALA C 1 159 ? 39.949  18.563  64.991  1.00 22.49  ? 159 ALA H CA  1 
ATOM   4442 C C   . ALA C 1 159 ? 39.614  17.235  65.655  1.00 22.28  ? 159 ALA H C   1 
ATOM   4443 O O   . ALA C 1 159 ? 40.509  16.425  65.882  1.00 22.60  ? 159 ALA H O   1 
ATOM   4444 C CB  . ALA C 1 159 ? 40.459  19.524  66.033  1.00 20.33  ? 159 ALA H CB  1 
ATOM   4445 N N   . LEU C 1 160 ? 38.339  17.066  66.029  1.00 20.98  ? 160 LEU H N   1 
ATOM   4446 C CA  . LEU C 1 160 ? 37.861  15.821  66.596  1.00 21.12  ? 160 LEU H CA  1 
ATOM   4447 C C   . LEU C 1 160 ? 36.959  15.100  65.594  1.00 19.28  ? 160 LEU H C   1 
ATOM   4448 O O   . LEU C 1 160 ? 35.859  15.552  65.313  1.00 19.48  ? 160 LEU H O   1 
ATOM   4449 C CB  . LEU C 1 160 ? 37.139  16.142  67.906  1.00 20.99  ? 160 LEU H CB  1 
ATOM   4450 C CG  . LEU C 1 160 ? 36.446  14.954  68.581  1.00 21.65  ? 160 LEU H CG  1 
ATOM   4451 C CD1 . LEU C 1 160 ? 37.426  13.834  68.973  1.00 20.83  ? 160 LEU H CD1 1 
ATOM   4452 C CD2 . LEU C 1 160 ? 35.724  15.440  69.819  1.00 22.08  ? 160 LEU H CD2 1 
ATOM   4453 N N   . THR C 1 161 ? 37.460  13.992  65.041  1.00 21.09  ? 161 THR H N   1 
ATOM   4454 C CA  . THR C 1 161 ? 36.713  13.112  64.155  1.00 24.44  ? 161 THR H CA  1 
ATOM   4455 C C   . THR C 1 161 ? 36.708  11.679  64.671  1.00 26.30  ? 161 THR H C   1 
ATOM   4456 O O   . THR C 1 161 ? 35.848  10.880  64.311  1.00 30.67  ? 161 THR H O   1 
ATOM   4457 C CB  . THR C 1 161 ? 37.316  13.078  62.737  1.00 25.91  ? 161 THR H CB  1 
ATOM   4458 O OG1 . THR C 1 161 ? 38.607  12.454  62.792  1.00 28.14  ? 161 THR H OG1 1 
ATOM   4459 C CG2 . THR C 1 161 ? 37.412  14.464  62.119  1.00 23.94  ? 161 THR H CG2 1 
ATOM   4460 N N   . SER C 1 162 ? 37.706  11.307  65.460  1.00 26.41  ? 162 SER H N   1 
ATOM   4461 C CA  . SER C 1 162 ? 37.788  9.916   65.880  1.00 30.07  ? 162 SER H CA  1 
ATOM   4462 C C   . SER C 1 162 ? 36.630  9.576   66.839  1.00 27.58  ? 162 SER H C   1 
ATOM   4463 O O   . SER C 1 162 ? 36.347  10.300  67.788  1.00 30.41  ? 162 SER H O   1 
ATOM   4464 C CB  . SER C 1 162 ? 39.156  9.671   66.469  1.00 33.23  ? 162 SER H CB  1 
ATOM   4465 O OG  . SER C 1 162 ? 39.260  8.357   66.947  1.00 38.10  ? 162 SER H OG  1 
ATOM   4466 N N   . GLY C 1 163 ? 35.913  8.485   66.558  1.00 28.42  ? 163 GLY H N   1 
ATOM   4467 C CA  . GLY C 1 163 ? 34.752  8.062   67.338  1.00 25.87  ? 163 GLY H CA  1 
ATOM   4468 C C   . GLY C 1 163 ? 33.563  9.027   67.241  1.00 26.05  ? 163 GLY H C   1 
ATOM   4469 O O   . GLY C 1 163 ? 32.737  9.086   68.145  1.00 26.39  ? 163 GLY H O   1 
ATOM   4470 N N   . VAL C 1 164 ? 33.487  9.820   66.165  1.00 25.09  ? 164 VAL H N   1 
ATOM   4471 C CA  . VAL C 1 164 ? 32.324  10.662  65.934  1.00 23.91  ? 164 VAL H CA  1 
ATOM   4472 C C   . VAL C 1 164 ? 31.315  9.844   65.132  1.00 20.82  ? 164 VAL H C   1 
ATOM   4473 O O   . VAL C 1 164 ? 31.699  9.163   64.201  1.00 18.47  ? 164 VAL H O   1 
ATOM   4474 C CB  . VAL C 1 164 ? 32.706  11.969  65.206  1.00 24.27  ? 164 VAL H CB  1 
ATOM   4475 C CG1 . VAL C 1 164 ? 31.506  12.677  64.591  1.00 25.24  ? 164 VAL H CG1 1 
ATOM   4476 C CG2 . VAL C 1 164 ? 33.457  12.915  66.128  1.00 25.34  ? 164 VAL H CG2 1 
ATOM   4477 N N   . HIS C 1 165 ? 30.030  9.952   65.473  1.00 20.95  ? 165 HIS H N   1 
ATOM   4478 C CA  . HIS C 1 165 ? 28.967  9.304   64.708  1.00 21.19  ? 165 HIS H CA  1 
ATOM   4479 C C   . HIS C 1 165 ? 27.835  10.306  64.513  1.00 22.66  ? 165 HIS H C   1 
ATOM   4480 O O   . HIS C 1 165 ? 27.182  10.687  65.484  1.00 20.92  ? 165 HIS H O   1 
ATOM   4481 C CB  . HIS C 1 165 ? 28.386  8.092   65.442  1.00 19.88  ? 165 HIS H CB  1 
ATOM   4482 C CG  . HIS C 1 165 ? 29.341  6.966   65.573  1.00 20.28  ? 165 HIS H CG  1 
ATOM   4483 N ND1 . HIS C 1 165 ? 29.986  6.441   64.474  1.00 19.42  ? 165 HIS H ND1 1 
ATOM   4484 C CD2 . HIS C 1 165 ? 29.791  6.279   66.624  1.00 21.36  ? 165 HIS H CD2 1 
ATOM   4485 C CE1 . HIS C 1 165 ? 30.763  5.427   64.861  1.00 20.51  ? 165 HIS H CE1 1 
ATOM   4486 N NE2 . HIS C 1 165 ? 30.704  5.331   66.165  1.00 19.77  ? 165 HIS H NE2 1 
ATOM   4487 N N   . THR C 1 166 ? 27.645  10.737  63.263  1.00 22.47  ? 166 THR H N   1 
ATOM   4488 C CA  . THR C 1 166 ? 26.555  11.631  62.907  1.00 26.47  ? 166 THR H CA  1 
ATOM   4489 C C   . THR C 1 166 ? 25.494  10.809  62.167  1.00 27.50  ? 166 THR H C   1 
ATOM   4490 O O   . THR C 1 166 ? 25.689  10.326  61.059  1.00 24.42  ? 166 THR H O   1 
ATOM   4491 C CB  . THR C 1 166 ? 27.046  12.835  62.087  1.00 26.28  ? 166 THR H CB  1 
ATOM   4492 O OG1 . THR C 1 166 ? 28.018  13.558  62.862  1.00 26.70  ? 166 THR H OG1 1 
ATOM   4493 C CG2 . THR C 1 166 ? 25.914  13.755  61.666  1.00 27.01  ? 166 THR H CG2 1 
ATOM   4494 N N   . PHE C 1 167 ? 24.339  10.698  62.791  1.00 27.11  ? 167 PHE H N   1 
ATOM   4495 C CA  . PHE C 1 167 ? 23.307  9.799   62.327  1.00 27.11  ? 167 PHE H CA  1 
ATOM   4496 C C   . PHE C 1 167 ? 22.529  10.436  61.181  1.00 27.99  ? 167 PHE H C   1 
ATOM   4497 O O   . PHE C 1 167 ? 22.460  11.664  61.077  1.00 26.76  ? 167 PHE H O   1 
ATOM   4498 C CB  . PHE C 1 167 ? 22.405  9.471   63.508  1.00 24.75  ? 167 PHE H CB  1 
ATOM   4499 C CG  . PHE C 1 167 ? 23.073  8.628   64.558  1.00 25.24  ? 167 PHE H CG  1 
ATOM   4500 C CD1 . PHE C 1 167 ? 23.067  7.252   64.470  1.00 25.20  ? 167 PHE H CD1 1 
ATOM   4501 C CD2 . PHE C 1 167 ? 23.684  9.203   65.660  1.00 29.86  ? 167 PHE H CD2 1 
ATOM   4502 C CE1 . PHE C 1 167 ? 23.681  6.473   65.436  1.00 26.56  ? 167 PHE H CE1 1 
ATOM   4503 C CE2 . PHE C 1 167 ? 24.286  8.414   66.633  1.00 27.03  ? 167 PHE H CE2 1 
ATOM   4504 C CZ  . PHE C 1 167 ? 24.286  7.054   66.515  1.00 25.12  ? 167 PHE H CZ  1 
ATOM   4505 N N   . PRO C 1 168 ? 21.909  9.608   60.307  1.00 27.19  ? 168 PRO H N   1 
ATOM   4506 C CA  . PRO C 1 168 ? 20.997  10.106  59.277  1.00 29.99  ? 168 PRO H CA  1 
ATOM   4507 C C   . PRO C 1 168 ? 19.851  10.902  59.888  1.00 27.58  ? 168 PRO H C   1 
ATOM   4508 O O   . PRO C 1 168 ? 19.346  10.539  60.945  1.00 25.88  ? 168 PRO H O   1 
ATOM   4509 C CB  . PRO C 1 168 ? 20.419  8.842   58.609  1.00 31.57  ? 168 PRO H CB  1 
ATOM   4510 C CG  . PRO C 1 168 ? 21.349  7.722   59.017  1.00 31.65  ? 168 PRO H CG  1 
ATOM   4511 C CD  . PRO C 1 168 ? 21.970  8.141   60.335  1.00 29.24  ? 168 PRO H CD  1 
ATOM   4512 N N   . ALA C 1 169 ? 19.463  11.991  59.222  1.00 28.20  ? 169 ALA H N   1 
ATOM   4513 C CA  . ALA C 1 169 ? 18.360  12.818  59.688  1.00 30.04  ? 169 ALA H CA  1 
ATOM   4514 C C   . ALA C 1 169 ? 17.092  11.982  59.696  1.00 30.42  ? 169 ALA H C   1 
ATOM   4515 O O   . ALA C 1 169 ? 17.054  10.985  58.993  1.00 31.30  ? 169 ALA H O   1 
ATOM   4516 C CB  . ALA C 1 169 ? 18.183  14.026  58.787  1.00 29.88  ? 169 ALA H CB  1 
ATOM   4517 N N   . VAL C 1 170 ? 16.078  12.412  60.464  1.00 32.09  ? 170 VAL H N   1 
ATOM   4518 C CA  . VAL C 1 170 ? 14.732  11.853  60.359  1.00 34.33  ? 170 VAL H CA  1 
ATOM   4519 C C   . VAL C 1 170 ? 13.713  12.983  60.167  1.00 35.11  ? 170 VAL H C   1 
ATOM   4520 O O   . VAL C 1 170 ? 13.838  14.083  60.708  1.00 33.85  ? 170 VAL H O   1 
ATOM   4521 C CB  . VAL C 1 170 ? 14.363  10.950  61.554  1.00 33.72  ? 170 VAL H CB  1 
ATOM   4522 C CG1 . VAL C 1 170 ? 15.326  9.771   61.670  1.00 35.54  ? 170 VAL H CG1 1 
ATOM   4523 C CG2 . VAL C 1 170 ? 14.308  11.727  62.865  1.00 33.76  ? 170 VAL H CG2 1 
ATOM   4524 N N   . LEU C 1 171 ? 12.720  12.692  59.322  1.00 35.20  ? 171 LEU H N   1 
ATOM   4525 C CA  . LEU C 1 171 ? 11.599  13.572  59.074  1.00 35.60  ? 171 LEU H CA  1 
ATOM   4526 C C   . LEU C 1 171 ? 10.595  13.392  60.210  1.00 39.87  ? 171 LEU H C   1 
ATOM   4527 O O   . LEU C 1 171 ? 10.109  12.278  60.415  1.00 36.50  ? 171 LEU H O   1 
ATOM   4528 C CB  . LEU C 1 171 ? 10.988  13.199  57.717  1.00 35.65  ? 171 LEU H CB  1 
ATOM   4529 C CG  . LEU C 1 171 ? 9.937   14.165  57.162  1.00 36.37  ? 171 LEU H CG  1 
ATOM   4530 C CD1 . LEU C 1 171 ? 10.495  15.589  57.081  1.00 37.02  ? 171 LEU H CD1 1 
ATOM   4531 C CD2 . LEU C 1 171 ? 9.433   13.713  55.780  1.00 33.52  ? 171 LEU H CD2 1 
ATOM   4532 N N   . GLN C 1 172 ? 10.357  14.481  60.965  1.00 41.42  ? 172 GLN H N   1 
ATOM   4533 C CA  . GLN C 1 172 ? 9.342   14.508  62.005  1.00 43.83  ? 172 GLN H CA  1 
ATOM   4534 C C   . GLN C 1 172 ? 7.969   14.749  61.375  1.00 47.53  ? 172 GLN H C   1 
ATOM   4535 O O   . GLN C 1 172 ? 7.860   15.234  60.240  1.00 48.23  ? 172 GLN H O   1 
ATOM   4536 C CB  . GLN C 1 172 ? 9.676   15.562  63.061  1.00 38.51  ? 172 GLN H CB  1 
ATOM   4537 C CG  . GLN C 1 172 ? 10.747  15.089  64.040  1.00 42.76  ? 172 GLN H CG  1 
ATOM   4538 C CD  . GLN C 1 172 ? 11.591  16.189  64.637  1.00 44.63  ? 172 GLN H CD  1 
ATOM   4539 O OE1 . GLN C 1 172 ? 11.863  16.197  65.834  1.00 45.76  ? 172 GLN H OE1 1 
ATOM   4540 N NE2 . GLN C 1 172 ? 12.072  17.101  63.803  1.00 50.17  ? 172 GLN H NE2 1 
ATOM   4541 N N   . SER C 1 173 ? 6.925   14.419  62.144  1.00 41.20  ? 173 SER H N   1 
ATOM   4542 C CA  . SER C 1 173 ? 5.563   14.588  61.677  1.00 40.23  ? 173 SER H CA  1 
ATOM   4543 C C   . SER C 1 173 ? 5.278   16.073  61.496  1.00 35.41  ? 173 SER H C   1 
ATOM   4544 O O   . SER C 1 173 ? 4.381   16.442  60.759  1.00 40.09  ? 173 SER H O   1 
ATOM   4545 C CB  . SER C 1 173 ? 4.574   13.909  62.602  1.00 40.96  ? 173 SER H CB  1 
ATOM   4546 O OG  . SER C 1 173 ? 4.595   14.500  63.887  1.00 39.56  ? 173 SER H OG  1 
ATOM   4547 N N   . SER C 1 174 ? 6.077   16.928  62.127  1.00 34.90  ? 174 SER H N   1 
ATOM   4548 C CA  . SER C 1 174 ? 6.051   18.355  61.833  1.00 35.64  ? 174 SER H CA  1 
ATOM   4549 C C   . SER C 1 174 ? 6.298   18.665  60.354  1.00 34.83  ? 174 SER H C   1 
ATOM   4550 O O   . SER C 1 174 ? 5.906   19.735  59.893  1.00 34.13  ? 174 SER H O   1 
ATOM   4551 C CB  . SER C 1 174 ? 7.046   19.120  62.715  1.00 40.60  ? 174 SER H CB  1 
ATOM   4552 O OG  . SER C 1 174 ? 8.384   18.592  62.663  1.00 38.66  ? 174 SER H OG  1 
ATOM   4553 N N   . GLY C 1 175 ? 6.980   17.769  59.616  1.00 36.11  ? 175 GLY H N   1 
ATOM   4554 C CA  . GLY C 1 175 ? 7.559   18.118  58.320  1.00 34.80  ? 175 GLY H CA  1 
ATOM   4555 C C   . GLY C 1 175 ? 8.996   18.648  58.434  1.00 38.28  ? 175 GLY H C   1 
ATOM   4556 O O   . GLY C 1 175 ? 9.633   18.964  57.428  1.00 39.66  ? 175 GLY H O   1 
ATOM   4557 N N   . LEU C 1 176 ? 9.512   18.754  59.667  1.00 39.17  ? 176 LEU H N   1 
ATOM   4558 C CA  . LEU C 1 176 ? 10.852  19.264  59.889  1.00 40.80  ? 176 LEU H CA  1 
ATOM   4559 C C   . LEU C 1 176 ? 11.773  18.093  60.226  1.00 36.81  ? 176 LEU H C   1 
ATOM   4560 O O   . LEU C 1 176 ? 11.316  17.036  60.674  1.00 37.29  ? 176 LEU H O   1 
ATOM   4561 C CB  . LEU C 1 176 ? 10.837  20.300  61.019  1.00 41.74  ? 176 LEU H CB  1 
ATOM   4562 C CG  . LEU C 1 176 ? 10.030  21.573  60.780  1.00 45.54  ? 176 LEU H CG  1 
ATOM   4563 C CD1 . LEU C 1 176 ? 10.120  22.490  61.999  1.00 46.24  ? 176 LEU H CD1 1 
ATOM   4564 C CD2 . LEU C 1 176 ? 10.495  22.320  59.535  1.00 46.34  ? 176 LEU H CD2 1 
ATOM   4565 N N   . TYR C 1 177 ? 13.079  18.306  60.020  1.00 33.45  ? 177 TYR H N   1 
ATOM   4566 C CA  . TYR C 1 177 ? 14.074  17.248  60.203  1.00 37.08  ? 177 TYR H CA  1 
ATOM   4567 C C   . TYR C 1 177 ? 14.752  17.372  61.572  1.00 35.13  ? 177 TYR H C   1 
ATOM   4568 O O   . TYR C 1 177 ? 14.656  18.399  62.247  1.00 32.36  ? 177 TYR H O   1 
ATOM   4569 C CB  . TYR C 1 177 ? 15.102  17.268  59.063  1.00 35.15  ? 177 TYR H CB  1 
ATOM   4570 C CG  . TYR C 1 177 ? 14.588  16.702  57.766  1.00 36.24  ? 177 TYR H CG  1 
ATOM   4571 C CD1 . TYR C 1 177 ? 14.500  15.336  57.563  1.00 39.07  ? 177 TYR H CD1 1 
ATOM   4572 C CD2 . TYR C 1 177 ? 14.157  17.530  56.746  1.00 40.38  ? 177 TYR H CD2 1 
ATOM   4573 C CE1 . TYR C 1 177 ? 14.020  14.800  56.376  1.00 38.83  ? 177 TYR H CE1 1 
ATOM   4574 C CE2 . TYR C 1 177 ? 13.649  17.013  55.563  1.00 43.40  ? 177 TYR H CE2 1 
ATOM   4575 C CZ  . TYR C 1 177 ? 13.590  15.644  55.374  1.00 39.43  ? 177 TYR H CZ  1 
ATOM   4576 O OH  . TYR C 1 177 ? 13.108  15.148  54.201  1.00 44.33  ? 177 TYR H OH  1 
ATOM   4577 N N   . SER C 1 178 ? 15.472  16.309  61.942  1.00 38.62  ? 178 SER H N   1 
ATOM   4578 C CA  . SER C 1 178 ? 16.213  16.230  63.193  1.00 40.31  ? 178 SER H CA  1 
ATOM   4579 C C   . SER C 1 178 ? 17.329  15.187  63.066  1.00 36.43  ? 178 SER H C   1 
ATOM   4580 O O   . SER C 1 178 ? 17.062  14.107  62.542  1.00 33.63  ? 178 SER H O   1 
ATOM   4581 C CB  . SER C 1 178 ? 15.247  15.906  64.320  1.00 41.04  ? 178 SER H CB  1 
ATOM   4582 O OG  . SER C 1 178 ? 15.933  15.655  65.537  1.00 47.88  ? 178 SER H OG  1 
ATOM   4583 N N   . LEU C 1 179 ? 18.574  15.506  63.497  1.00 35.75  ? 179 LEU H N   1 
ATOM   4584 C CA  . LEU C 1 179 ? 19.587  14.468  63.725  1.00 34.78  ? 179 LEU H CA  1 
ATOM   4585 C C   . LEU C 1 179 ? 20.381  14.713  65.007  1.00 32.40  ? 179 LEU H C   1 
ATOM   4586 O O   . LEU C 1 179 ? 20.402  15.823  65.539  1.00 32.24  ? 179 LEU H O   1 
ATOM   4587 C CB  . LEU C 1 179 ? 20.551  14.303  62.538  1.00 36.38  ? 179 LEU H CB  1 
ATOM   4588 C CG  . LEU C 1 179 ? 21.430  15.490  62.128  1.00 35.07  ? 179 LEU H CG  1 
ATOM   4589 C CD1 . LEU C 1 179 ? 22.613  15.674  63.058  1.00 34.36  ? 179 LEU H CD1 1 
ATOM   4590 C CD2 . LEU C 1 179 ? 21.942  15.302  60.702  1.00 34.62  ? 179 LEU H CD2 1 
ATOM   4591 N N   . SER C 1 180 ? 21.039  13.627  65.441  1.00 33.76  ? 180 SER H N   1 
ATOM   4592 C CA  . SER C 1 180 ? 22.027  13.597  66.509  1.00 35.33  ? 180 SER H CA  1 
ATOM   4593 C C   . SER C 1 180 ? 23.433  13.331  65.970  1.00 32.49  ? 180 SER H C   1 
ATOM   4594 O O   . SER C 1 180 ? 23.611  12.448  65.145  1.00 30.24  ? 180 SER H O   1 
ATOM   4595 C CB  . SER C 1 180 ? 21.676  12.548  67.500  1.00 33.56  ? 180 SER H CB  1 
ATOM   4596 O OG  . SER C 1 180 ? 20.512  12.944  68.186  1.00 42.18  ? 180 SER H OG  1 
ATOM   4597 N N   . SER C 1 181 ? 24.421  14.086  66.474  1.00 29.72  ? 181 SER H N   1 
ATOM   4598 C CA  . SER C 1 181 ? 25.829  13.731  66.364  1.00 25.92  ? 181 SER H CA  1 
ATOM   4599 C C   . SER C 1 181 ? 26.384  13.428  67.752  1.00 24.41  ? 181 SER H C   1 
ATOM   4600 O O   . SER C 1 181 ? 26.094  14.177  68.670  1.00 23.22  ? 181 SER H O   1 
ATOM   4601 C CB  . SER C 1 181 ? 26.616  14.821  65.715  1.00 26.23  ? 181 SER H CB  1 
ATOM   4602 O OG  . SER C 1 181 ? 27.954  14.389  65.496  1.00 24.87  ? 181 SER H OG  1 
ATOM   4603 N N   . VAL C 1 182 ? 27.124  12.314  67.881  1.00 22.51  ? 182 VAL H N   1 
ATOM   4604 C CA  . VAL C 1 182 ? 27.710  11.857  69.131  1.00 23.23  ? 182 VAL H CA  1 
ATOM   4605 C C   . VAL C 1 182 ? 29.189  11.539  68.920  1.00 21.29  ? 182 VAL H C   1 
ATOM   4606 O O   . VAL C 1 182 ? 29.631  11.235  67.828  1.00 20.35  ? 182 VAL H O   1 
ATOM   4607 C CB  . VAL C 1 182 ? 27.010  10.613  69.707  1.00 23.18  ? 182 VAL H CB  1 
ATOM   4608 C CG1 . VAL C 1 182 ? 25.546  10.863  70.023  1.00 24.54  ? 182 VAL H CG1 1 
ATOM   4609 C CG2 . VAL C 1 182 ? 27.158  9.427   68.781  1.00 23.52  ? 182 VAL H CG2 1 
ATOM   4610 N N   . VAL C 1 183 ? 29.929  11.542  70.020  1.00 23.47  ? 183 VAL H N   1 
ATOM   4611 C CA  . VAL C 1 183 ? 31.307  11.091  70.027  1.00 24.56  ? 183 VAL H CA  1 
ATOM   4612 C C   . VAL C 1 183 ? 31.583  10.457  71.390  1.00 22.89  ? 183 VAL H C   1 
ATOM   4613 O O   . VAL C 1 183 ? 31.005  10.846  72.396  1.00 23.30  ? 183 VAL H O   1 
ATOM   4614 C CB  . VAL C 1 183 ? 32.246  12.266  69.692  1.00 24.66  ? 183 VAL H CB  1 
ATOM   4615 C CG1 . VAL C 1 183 ? 31.913  13.465  70.547  1.00 27.78  ? 183 VAL H CG1 1 
ATOM   4616 C CG2 . VAL C 1 183 ? 33.716  11.891  69.811  1.00 25.94  ? 183 VAL H CG2 1 
ATOM   4617 N N   . THR C 1 184 ? 32.426  9.430   71.392  1.00 23.66  ? 184 THR H N   1 
ATOM   4618 C CA  . THR C 1 184 ? 32.921  8.824   72.613  1.00 27.06  ? 184 THR H CA  1 
ATOM   4619 C C   . THR C 1 184 ? 34.366  9.287   72.852  1.00 27.66  ? 184 THR H C   1 
ATOM   4620 O O   . THR C 1 184 ? 35.147  9.399   71.912  1.00 24.15  ? 184 THR H O   1 
ATOM   4621 C CB  . THR C 1 184 ? 32.800  7.302   72.525  1.00 27.68  ? 184 THR H CB  1 
ATOM   4622 O OG1 . THR C 1 184 ? 33.284  6.940   71.233  1.00 30.94  ? 184 THR H OG1 1 
ATOM   4623 C CG2 . THR C 1 184 ? 31.380  6.813   72.685  1.00 27.46  ? 184 THR H CG2 1 
ATOM   4624 N N   . VAL C 1 185 ? 34.693  9.551   74.126  1.00 29.05  ? 185 VAL H N   1 
ATOM   4625 C CA  . VAL C 1 185 ? 35.939  10.186  74.535  1.00 33.68  ? 185 VAL H CA  1 
ATOM   4626 C C   . VAL C 1 185 ? 36.418  9.511   75.825  1.00 36.42  ? 185 VAL H C   1 
ATOM   4627 O O   . VAL C 1 185 ? 35.607  8.923   76.544  1.00 32.57  ? 185 VAL H O   1 
ATOM   4628 C CB  . VAL C 1 185 ? 35.762  11.709  74.736  1.00 33.55  ? 185 VAL H CB  1 
ATOM   4629 C CG1 . VAL C 1 185 ? 35.249  12.404  73.476  1.00 33.68  ? 185 VAL H CG1 1 
ATOM   4630 C CG2 . VAL C 1 185 ? 34.857  12.041  75.930  1.00 33.98  ? 185 VAL H CG2 1 
ATOM   4631 N N   . PRO C 1 186 ? 37.730  9.587   76.168  1.00 37.77  ? 186 PRO H N   1 
ATOM   4632 C CA  . PRO C 1 186 ? 38.216  9.126   77.473  1.00 36.79  ? 186 PRO H CA  1 
ATOM   4633 C C   . PRO C 1 186 ? 37.468  9.862   78.571  1.00 33.04  ? 186 PRO H C   1 
ATOM   4634 O O   . PRO C 1 186 ? 37.292  11.069  78.486  1.00 35.84  ? 186 PRO H O   1 
ATOM   4635 C CB  . PRO C 1 186 ? 39.705  9.518   77.497  1.00 37.61  ? 186 PRO H CB  1 
ATOM   4636 C CG  . PRO C 1 186 ? 40.084  9.671   76.040  1.00 37.56  ? 186 PRO H CG  1 
ATOM   4637 C CD  . PRO C 1 186 ? 38.815  10.147  75.340  1.00 38.82  ? 186 PRO H CD  1 
ATOM   4638 N N   . SER C 1 187 ? 36.982  9.147   79.579  1.00 37.98  ? 187 SER H N   1 
ATOM   4639 C CA  . SER C 1 187 ? 36.268  9.813   80.658  1.00 44.21  ? 187 SER H CA  1 
ATOM   4640 C C   . SER C 1 187 ? 37.206  10.721  81.466  1.00 40.32  ? 187 SER H C   1 
ATOM   4641 O O   . SER C 1 187 ? 36.749  11.692  82.056  1.00 42.90  ? 187 SER H O   1 
ATOM   4642 C CB  . SER C 1 187 ? 35.541  8.817   81.524  1.00 45.34  ? 187 SER H CB  1 
ATOM   4643 O OG  . SER C 1 187 ? 36.382  7.714   81.800  1.00 51.88  ? 187 SER H OG  1 
ATOM   4644 N N   . SER C 1 188 ? 38.517  10.444  81.465  1.00 44.18  ? 188 SER H N   1 
ATOM   4645 C CA  . SER C 1 188 ? 39.471  11.312  82.147  1.00 49.32  ? 188 SER H CA  1 
ATOM   4646 C C   . SER C 1 188 ? 39.420  12.723  81.564  1.00 52.76  ? 188 SER H C   1 
ATOM   4647 O O   . SER C 1 188 ? 39.692  13.687  82.276  1.00 66.36  ? 188 SER H O   1 
ATOM   4648 C CB  . SER C 1 188 ? 40.871  10.753  82.101  1.00 47.85  ? 188 SER H CB  1 
ATOM   4649 O OG  . SER C 1 188 ? 41.384  10.754  80.782  1.00 50.08  ? 188 SER H OG  1 
ATOM   4650 N N   . SER C 1 189 ? 39.056  12.830  80.277  1.00 48.91  ? 189 SER H N   1 
ATOM   4651 C CA  . SER C 1 189 ? 39.068  14.082  79.531  1.00 49.97  ? 189 SER H CA  1 
ATOM   4652 C C   . SER C 1 189 ? 37.957  15.050  79.952  1.00 43.27  ? 189 SER H C   1 
ATOM   4653 O O   . SER C 1 189 ? 38.079  16.248  79.709  1.00 40.76  ? 189 SER H O   1 
ATOM   4654 C CB  . SER C 1 189 ? 38.984  13.822  78.048  1.00 53.69  ? 189 SER H CB  1 
ATOM   4655 O OG  . SER C 1 189 ? 40.153  13.162  77.586  1.00 63.85  ? 189 SER H OG  1 
ATOM   4656 N N   . LEU C 1 190 ? 36.858  14.553  80.527  1.00 37.98  ? 190 LEU H N   1 
ATOM   4657 C CA  . LEU C 1 190 ? 35.731  15.425  80.816  1.00 43.62  ? 190 LEU H CA  1 
ATOM   4658 C C   . LEU C 1 190 ? 36.150  16.455  81.859  1.00 50.45  ? 190 LEU H C   1 
ATOM   4659 O O   . LEU C 1 190 ? 36.926  16.151  82.769  1.00 57.24  ? 190 LEU H O   1 
ATOM   4660 C CB  . LEU C 1 190 ? 34.540  14.613  81.327  1.00 41.56  ? 190 LEU H CB  1 
ATOM   4661 C CG  . LEU C 1 190 ? 33.974  13.565  80.369  1.00 41.34  ? 190 LEU H CG  1 
ATOM   4662 C CD1 . LEU C 1 190 ? 32.869  12.769  81.043  1.00 38.73  ? 190 LEU H CD1 1 
ATOM   4663 C CD2 . LEU C 1 190 ? 33.457  14.210  79.094  1.00 42.44  ? 190 LEU H CD2 1 
ATOM   4664 N N   . GLY C 1 191 ? 35.624  17.674  81.706  1.00 51.60  ? 191 GLY H N   1 
ATOM   4665 C CA  . GLY C 1 191 ? 35.999  18.793  82.552  1.00 56.04  ? 191 GLY H CA  1 
ATOM   4666 C C   . GLY C 1 191 ? 37.314  19.457  82.137  1.00 60.14  ? 191 GLY H C   1 
ATOM   4667 O O   . GLY C 1 191 ? 37.534  20.615  82.484  1.00 63.61  ? 191 GLY H O   1 
ATOM   4668 N N   . THR C 1 192 ? 38.188  18.728  81.417  1.00 66.29  ? 192 THR H N   1 
ATOM   4669 C CA  . THR C 1 192 ? 39.470  19.250  80.955  1.00 63.44  ? 192 THR H CA  1 
ATOM   4670 C C   . THR C 1 192 ? 39.329  19.714  79.504  1.00 60.39  ? 192 THR H C   1 
ATOM   4671 O O   . THR C 1 192 ? 39.250  20.915  79.235  1.00 58.35  ? 192 THR H O   1 
ATOM   4672 C CB  . THR C 1 192 ? 40.590  18.207  81.095  1.00 61.74  ? 192 THR H CB  1 
ATOM   4673 O OG1 . THR C 1 192 ? 40.335  17.403  82.245  1.00 69.22  ? 192 THR H OG1 1 
ATOM   4674 C CG2 . THR C 1 192 ? 41.959  18.841  81.199  1.00 62.89  ? 192 THR H CG2 1 
ATOM   4675 N N   . GLN C 1 193 ? 39.268  18.736  78.588  1.00 50.93  ? 193 GLN H N   1 
ATOM   4676 C CA  . GLN C 1 193 ? 39.090  18.977  77.167  1.00 43.21  ? 193 GLN H CA  1 
ATOM   4677 C C   . GLN C 1 193 ? 37.751  19.680  76.956  1.00 38.63  ? 193 GLN H C   1 
ATOM   4678 O O   . GLN C 1 193 ? 36.784  19.348  77.625  1.00 34.48  ? 193 GLN H O   1 
ATOM   4679 C CB  . GLN C 1 193 ? 39.130  17.631  76.442  1.00 42.57  ? 193 GLN H CB  1 
ATOM   4680 C CG  . GLN C 1 193 ? 38.908  17.724  74.941  1.00 46.92  ? 193 GLN H CG  1 
ATOM   4681 C CD  . GLN C 1 193 ? 39.951  18.593  74.282  1.00 46.88  ? 193 GLN H CD  1 
ATOM   4682 O OE1 . GLN C 1 193 ? 41.134  18.498  74.594  1.00 49.43  ? 193 GLN H OE1 1 
ATOM   4683 N NE2 . GLN C 1 193 ? 39.520  19.460  73.382  1.00 45.63  ? 193 GLN H NE2 1 
ATOM   4684 N N   . THR C 1 194 ? 37.694  20.655  76.039  1.00 36.78  ? 194 THR H N   1 
ATOM   4685 C CA  . THR C 1 194 ? 36.413  21.239  75.667  1.00 35.90  ? 194 THR H CA  1 
ATOM   4686 C C   . THR C 1 194 ? 35.877  20.535  74.414  1.00 31.33  ? 194 THR H C   1 
ATOM   4687 O O   . THR C 1 194 ? 36.655  20.118  73.543  1.00 29.43  ? 194 THR H O   1 
ATOM   4688 C CB  . THR C 1 194 ? 36.521  22.758  75.506  1.00 34.56  ? 194 THR H CB  1 
ATOM   4689 O OG1 . THR C 1 194 ? 37.319  22.971  74.348  1.00 42.15  ? 194 THR H OG1 1 
ATOM   4690 C CG2 . THR C 1 194 ? 37.124  23.441  76.713  1.00 33.77  ? 194 THR H CG2 1 
ATOM   4691 N N   . TYR C 1 195 ? 34.547  20.379  74.363  1.00 27.48  ? 195 TYR H N   1 
ATOM   4692 C CA  . TYR C 1 195 ? 33.853  19.755  73.236  1.00 26.85  ? 195 TYR H CA  1 
ATOM   4693 C C   . TYR C 1 195 ? 32.762  20.700  72.733  1.00 26.11  ? 195 TYR H C   1 
ATOM   4694 O O   . TYR C 1 195 ? 31.888  21.104  73.494  1.00 27.37  ? 195 TYR H O   1 
ATOM   4695 C CB  . TYR C 1 195 ? 33.283  18.390  73.640  1.00 25.84  ? 195 TYR H CB  1 
ATOM   4696 C CG  . TYR C 1 195 ? 34.327  17.368  74.019  1.00 24.70  ? 195 TYR H CG  1 
ATOM   4697 C CD1 . TYR C 1 195 ? 35.200  16.844  73.080  1.00 25.00  ? 195 TYR H CD1 1 
ATOM   4698 C CD2 . TYR C 1 195 ? 34.491  16.981  75.339  1.00 24.16  ? 195 TYR H CD2 1 
ATOM   4699 C CE1 . TYR C 1 195 ? 36.199  15.949  73.430  1.00 23.95  ? 195 TYR H CE1 1 
ATOM   4700 C CE2 . TYR C 1 195 ? 35.473  16.080  75.709  1.00 24.64  ? 195 TYR H CE2 1 
ATOM   4701 C CZ  . TYR C 1 195 ? 36.329  15.562  74.753  1.00 24.98  ? 195 TYR H CZ  1 
ATOM   4702 O OH  . TYR C 1 195 ? 37.292  14.665  75.150  1.00 26.69  ? 195 TYR H OH  1 
ATOM   4703 N N   . ILE C 1 196 ? 32.870  21.075  71.455  1.00 25.10  ? 196 ILE H N   1 
ATOM   4704 C CA  . ILE C 1 196 ? 31.996  22.024  70.787  1.00 27.72  ? 196 ILE H CA  1 
ATOM   4705 C C   . ILE C 1 196 ? 31.523  21.383  69.486  1.00 24.37  ? 196 ILE H C   1 
ATOM   4706 O O   . ILE C 1 196 ? 32.338  20.896  68.727  1.00 22.25  ? 196 ILE H O   1 
ATOM   4707 C CB  . ILE C 1 196 ? 32.747  23.358  70.530  1.00 32.30  ? 196 ILE H CB  1 
ATOM   4708 C CG1 . ILE C 1 196 ? 33.094  24.094  71.833  1.00 32.79  ? 196 ILE H CG1 1 
ATOM   4709 C CG2 . ILE C 1 196 ? 31.956  24.265  69.594  1.00 31.85  ? 196 ILE H CG2 1 
ATOM   4710 C CD1 . ILE C 1 196 ? 34.031  25.277  71.646  1.00 35.13  ? 196 ILE H CD1 1 
ATOM   4711 N N   . CYS C 1 197 ? 30.221  21.352  69.216  1.00 25.33  ? 197 CYS H N   1 
ATOM   4712 C CA  . CYS C 1 197 ? 29.769  20.886  67.909  1.00 28.79  ? 197 CYS H CA  1 
ATOM   4713 C C   . CYS C 1 197 ? 29.431  22.079  67.021  1.00 26.48  ? 197 CYS H C   1 
ATOM   4714 O O   . CYS C 1 197 ? 28.634  22.946  67.395  1.00 29.46  ? 197 CYS H O   1 
ATOM   4715 C CB  . CYS C 1 197 ? 28.570  19.947  67.995  1.00 34.07  ? 197 CYS H CB  1 
ATOM   4716 S SG  . CYS C 1 197 ? 27.091  20.784  68.598  1.00 43.23  ? 197 CYS H SG  1 
ATOM   4717 N N   . ASN C 1 198 ? 30.062  22.091  65.847  1.00 24.00  ? 198 ASN H N   1 
ATOM   4718 C CA  . ASN C 1 198 ? 29.883  23.116  64.834  1.00 23.90  ? 198 ASN H CA  1 
ATOM   4719 C C   . ASN C 1 198 ? 28.820  22.596  63.885  1.00 24.01  ? 198 ASN H C   1 
ATOM   4720 O O   . ASN C 1 198 ? 29.052  21.600  63.217  1.00 23.93  ? 198 ASN H O   1 
ATOM   4721 C CB  . ASN C 1 198 ? 31.205  23.424  64.112  1.00 24.72  ? 198 ASN H CB  1 
ATOM   4722 C CG  . ASN C 1 198 ? 32.387  23.326  65.059  1.00 27.23  ? 198 ASN H CG  1 
ATOM   4723 O OD1 . ASN C 1 198 ? 33.178  22.384  65.010  1.00 32.07  ? 198 ASN H OD1 1 
ATOM   4724 N ND2 . ASN C 1 198 ? 32.439  24.230  66.015  1.00 26.58  ? 198 ASN H ND2 1 
ATOM   4725 N N   . VAL C 1 199 ? 27.657  23.252  63.895  1.00 25.77  ? 199 VAL H N   1 
ATOM   4726 C CA  . VAL C 1 199 ? 26.515  22.888  63.075  1.00 26.12  ? 199 VAL H CA  1 
ATOM   4727 C C   . VAL C 1 199 ? 26.337  23.951  61.995  1.00 26.24  ? 199 VAL H C   1 
ATOM   4728 O O   . VAL C 1 199 ? 26.280  25.130  62.314  1.00 27.14  ? 199 VAL H O   1 
ATOM   4729 C CB  . VAL C 1 199 ? 25.241  22.755  63.931  1.00 25.80  ? 199 VAL H CB  1 
ATOM   4730 C CG1 . VAL C 1 199 ? 24.041  22.317  63.103  1.00 25.89  ? 199 VAL H CG1 1 
ATOM   4731 C CG2 . VAL C 1 199 ? 25.463  21.809  65.094  1.00 25.72  ? 199 VAL H CG2 1 
ATOM   4732 N N   . ASN C 1 200 ? 26.219  23.517  60.734  1.00 25.31  ? 200 ASN H N   1 
ATOM   4733 C CA  . ASN C 1 200 ? 25.970  24.403  59.612  1.00 27.31  ? 200 ASN H CA  1 
ATOM   4734 C C   . ASN C 1 200 ? 24.721  24.018  58.836  1.00 25.28  ? 200 ASN H C   1 
ATOM   4735 O O   . ASN C 1 200 ? 24.640  22.888  58.377  1.00 26.26  ? 200 ASN H O   1 
ATOM   4736 C CB  . ASN C 1 200 ? 27.098  24.356  58.595  1.00 33.56  ? 200 ASN H CB  1 
ATOM   4737 C CG  . ASN C 1 200 ? 27.876  25.644  58.606  1.00 42.83  ? 200 ASN H CG  1 
ATOM   4738 O OD1 . ASN C 1 200 ? 27.349  26.677  58.196  1.00 40.78  ? 200 ASN H OD1 1 
ATOM   4739 N ND2 . ASN C 1 200 ? 29.095  25.585  59.122  1.00 51.94  ? 200 ASN H ND2 1 
ATOM   4740 N N   . HIS C 1 201 ? 23.798  24.974  58.661  1.00 24.40  ? 201 HIS H N   1 
ATOM   4741 C CA  . HIS C 1 201 ? 22.632  24.816  57.793  1.00 28.11  ? 201 HIS H CA  1 
ATOM   4742 C C   . HIS C 1 201 ? 22.653  25.902  56.719  1.00 28.14  ? 201 HIS H C   1 
ATOM   4743 O O   . HIS C 1 201 ? 22.129  26.996  56.945  1.00 28.47  ? 201 HIS H O   1 
ATOM   4744 C CB  . HIS C 1 201 ? 21.314  24.921  58.571  1.00 26.32  ? 201 HIS H CB  1 
ATOM   4745 C CG  . HIS C 1 201 ? 20.120  24.549  57.773  1.00 26.75  ? 201 HIS H CG  1 
ATOM   4746 N ND1 . HIS C 1 201 ? 19.079  25.421  57.542  1.00 26.78  ? 201 HIS H ND1 1 
ATOM   4747 C CD2 . HIS C 1 201 ? 19.760  23.374  57.198  1.00 28.05  ? 201 HIS H CD2 1 
ATOM   4748 C CE1 . HIS C 1 201 ? 18.146  24.798  56.823  1.00 29.35  ? 201 HIS H CE1 1 
ATOM   4749 N NE2 . HIS C 1 201 ? 18.537  23.557  56.593  1.00 26.51  ? 201 HIS H NE2 1 
ATOM   4750 N N   . LYS C 1 202 ? 23.256  25.590  55.562  1.00 26.52  ? 202 LYS H N   1 
ATOM   4751 C CA  . LYS C 1 202 ? 23.530  26.603  54.557  1.00 28.06  ? 202 LYS H CA  1 
ATOM   4752 C C   . LYS C 1 202 ? 22.243  27.251  54.065  1.00 28.18  ? 202 LYS H C   1 
ATOM   4753 O O   . LYS C 1 202 ? 22.226  28.475  53.918  1.00 28.04  ? 202 LYS H O   1 
ATOM   4754 C CB  . LYS C 1 202 ? 24.294  26.058  53.344  1.00 30.62  ? 202 LYS H CB  1 
ATOM   4755 C CG  . LYS C 1 202 ? 24.721  27.142  52.352  1.00 33.53  ? 202 LYS H CG  1 
ATOM   4756 C CD  . LYS C 1 202 ? 25.052  26.657  50.947  1.00 36.04  ? 202 LYS H CD  1 
ATOM   4757 C CE  . LYS C 1 202 ? 25.744  27.726  50.133  1.00 35.77  ? 202 LYS H CE  1 
ATOM   4758 N NZ  . LYS C 1 202 ? 26.198  27.249  48.807  1.00 37.17  ? 202 LYS H NZ  1 
ATOM   4759 N N   . PRO C 1 203 ? 21.165  26.475  53.767  1.00 27.40  ? 203 PRO H N   1 
ATOM   4760 C CA  . PRO C 1 203 ? 19.909  27.037  53.271  1.00 29.66  ? 203 PRO H CA  1 
ATOM   4761 C C   . PRO C 1 203 ? 19.331  28.197  54.077  1.00 31.09  ? 203 PRO H C   1 
ATOM   4762 O O   . PRO C 1 203 ? 18.801  29.114  53.469  1.00 34.16  ? 203 PRO H O   1 
ATOM   4763 C CB  . PRO C 1 203 ? 18.924  25.856  53.299  1.00 30.31  ? 203 PRO H CB  1 
ATOM   4764 C CG  . PRO C 1 203 ? 19.833  24.646  53.128  1.00 30.11  ? 203 PRO H CG  1 
ATOM   4765 C CD  . PRO C 1 203 ? 21.080  25.010  53.910  1.00 30.20  ? 203 PRO H CD  1 
ATOM   4766 N N   . SER C 1 204 ? 19.456  28.173  55.418  1.00 31.52  ? 204 SER H N   1 
ATOM   4767 C CA  . SER C 1 204 ? 19.003  29.280  56.266  1.00 30.56  ? 204 SER H CA  1 
ATOM   4768 C C   . SER C 1 204 ? 20.159  30.175  56.751  1.00 29.98  ? 204 SER H C   1 
ATOM   4769 O O   . SER C 1 204 ? 19.957  31.033  57.605  1.00 28.51  ? 204 SER H O   1 
ATOM   4770 C CB  . SER C 1 204 ? 18.247  28.741  57.449  1.00 28.23  ? 204 SER H CB  1 
ATOM   4771 O OG  . SER C 1 204 ? 19.129  27.985  58.261  1.00 27.04  ? 204 SER H OG  1 
ATOM   4772 N N   . ASN C 1 205 ? 21.376  29.983  56.226  1.00 27.73  ? 205 ASN H N   1 
ATOM   4773 C CA  . ASN C 1 205 ? 22.565  30.637  56.754  1.00 28.27  ? 205 ASN H CA  1 
ATOM   4774 C C   . ASN C 1 205 ? 22.621  30.547  58.279  1.00 30.08  ? 205 ASN H C   1 
ATOM   4775 O O   . ASN C 1 205 ? 22.903  31.546  58.942  1.00 25.36  ? 205 ASN H O   1 
ATOM   4776 C CB  . ASN C 1 205 ? 22.641  32.116  56.383  1.00 29.56  ? 205 ASN H CB  1 
ATOM   4777 C CG  . ASN C 1 205 ? 24.051  32.638  56.555  1.00 32.77  ? 205 ASN H CG  1 
ATOM   4778 O OD1 . ASN C 1 205 ? 24.958  31.864  56.858  1.00 37.68  ? 205 ASN H OD1 1 
ATOM   4779 N ND2 . ASN C 1 205 ? 24.265  33.920  56.316  1.00 31.95  ? 205 ASN H ND2 1 
ATOM   4780 N N   . THR C 1 206 ? 22.319  29.361  58.836  1.00 33.64  ? 206 THR H N   1 
ATOM   4781 C CA  . THR C 1 206 ? 22.353  29.140  60.281  1.00 36.75  ? 206 THR H CA  1 
ATOM   4782 C C   . THR C 1 206 ? 23.641  28.398  60.636  1.00 36.56  ? 206 THR H C   1 
ATOM   4783 O O   . THR C 1 206 ? 23.937  27.346  60.053  1.00 37.13  ? 206 THR H O   1 
ATOM   4784 C CB  . THR C 1 206 ? 21.086  28.417  60.774  1.00 38.94  ? 206 THR H CB  1 
ATOM   4785 O OG1 . THR C 1 206 ? 19.978  29.207  60.361  1.00 41.77  ? 206 THR H OG1 1 
ATOM   4786 C CG2 . THR C 1 206 ? 21.000  28.248  62.277  1.00 42.52  ? 206 THR H CG2 1 
ATOM   4787 N N   . LYS C 1 207 ? 24.401  28.988  61.575  1.00 37.22  ? 207 LYS H N   1 
ATOM   4788 C CA  . LYS C 1 207 ? 25.670  28.458  62.058  1.00 35.35  ? 207 LYS H CA  1 
ATOM   4789 C C   . LYS C 1 207 ? 25.668  28.450  63.590  1.00 29.78  ? 207 LYS H C   1 
ATOM   4790 O O   . LYS C 1 207 ? 25.627  29.490  64.227  1.00 27.24  ? 207 LYS H O   1 
ATOM   4791 C CB  . LYS C 1 207 ? 26.814  29.313  61.498  1.00 40.44  ? 207 LYS H CB  1 
ATOM   4792 C CG  . LYS C 1 207 ? 28.221  28.985  62.003  1.00 50.60  ? 207 LYS H CG  1 
ATOM   4793 C CD  . LYS C 1 207 ? 28.989  30.236  62.490  1.00 60.37  ? 207 LYS H CD  1 
ATOM   4794 C CE  . LYS C 1 207 ? 30.499  30.189  62.340  1.00 59.90  ? 207 LYS H CE  1 
ATOM   4795 N NZ  . LYS C 1 207 ? 31.092  29.048  63.080  1.00 66.08  ? 207 LYS H NZ  1 
ATOM   4796 N N   . VAL C 1 208 ? 25.716  27.276  64.220  1.00 31.96  ? 208 VAL H N   1 
ATOM   4797 C CA  . VAL C 1 208 ? 25.733  27.227  65.678  1.00 31.25  ? 208 VAL H CA  1 
ATOM   4798 C C   . VAL C 1 208 ? 26.974  26.440  66.103  1.00 33.00  ? 208 VAL H C   1 
ATOM   4799 O O   . VAL C 1 208 ? 27.202  25.348  65.593  1.00 33.24  ? 208 VAL H O   1 
ATOM   4800 C CB  . VAL C 1 208 ? 24.410  26.644  66.230  1.00 28.58  ? 208 VAL H CB  1 
ATOM   4801 C CG1 . VAL C 1 208 ? 24.439  26.459  67.729  1.00 29.84  ? 208 VAL H CG1 1 
ATOM   4802 C CG2 . VAL C 1 208 ? 23.201  27.491  65.860  1.00 28.78  ? 208 VAL H CG2 1 
ATOM   4803 N N   . ASP C 1 209 ? 27.812  27.036  66.970  1.00 34.55  ? 209 ASP H N   1 
ATOM   4804 C CA  . ASP C 1 209 ? 28.876  26.319  67.666  1.00 37.47  ? 209 ASP H CA  1 
ATOM   4805 C C   . ASP C 1 209 ? 28.425  26.059  69.106  1.00 39.88  ? 209 ASP H C   1 
ATOM   4806 O O   . ASP C 1 209 ? 28.326  26.996  69.888  1.00 39.52  ? 209 ASP H O   1 
ATOM   4807 C CB  . ASP C 1 209 ? 30.192  27.105  67.611  1.00 39.93  ? 209 ASP H CB  1 
ATOM   4808 C CG  . ASP C 1 209 ? 30.644  27.451  66.197  1.00 46.20  ? 209 ASP H CG  1 
ATOM   4809 O OD1 . ASP C 1 209 ? 30.720  26.530  65.333  1.00 46.58  ? 209 ASP H OD1 1 
ATOM   4810 O OD2 . ASP C 1 209 ? 30.900  28.643  65.947  1.00 55.16  ? 209 ASP H OD2 1 
ATOM   4811 N N   . LYS C 1 210 ? 28.128  24.796  69.460  1.00 41.84  ? 210 LYS H N   1 
ATOM   4812 C CA  . LYS C 1 210 ? 27.531  24.481  70.759  1.00 37.88  ? 210 LYS H CA  1 
ATOM   4813 C C   . LYS C 1 210 ? 28.480  23.695  71.677  1.00 38.48  ? 210 LYS H C   1 
ATOM   4814 O O   . LYS C 1 210 ? 28.840  22.551  71.400  1.00 33.17  ? 210 LYS H O   1 
ATOM   4815 C CB  . LYS C 1 210 ? 26.250  23.664  70.563  1.00 38.61  ? 210 LYS H CB  1 
ATOM   4816 C CG  . LYS C 1 210 ? 25.577  23.187  71.843  1.00 39.27  ? 210 LYS H CG  1 
ATOM   4817 C CD  . LYS C 1 210 ? 25.105  24.312  72.725  1.00 42.53  ? 210 LYS H CD  1 
ATOM   4818 C CE  . LYS C 1 210 ? 24.157  25.252  72.009  1.00 45.95  ? 210 LYS H CE  1 
ATOM   4819 N NZ  . LYS C 1 210 ? 23.509  26.197  72.944  1.00 50.64  ? 210 LYS H NZ  1 
ATOM   4820 N N   . ARG C 1 211 ? 28.811  24.295  72.827  1.00 35.82  ? 211 ARG H N   1 
ATOM   4821 C CA  . ARG C 1 211 ? 29.645  23.665  73.831  1.00 36.37  ? 211 ARG H CA  1 
ATOM   4822 C C   . ARG C 1 211 ? 28.830  22.619  74.577  1.00 34.57  ? 211 ARG H C   1 
ATOM   4823 O O   . ARG C 1 211 ? 27.698  22.898  74.974  1.00 35.56  ? 211 ARG H O   1 
ATOM   4824 C CB  . ARG C 1 211 ? 30.134  24.717  74.828  1.00 42.69  ? 211 ARG H CB  1 
ATOM   4825 C CG  . ARG C 1 211 ? 31.277  24.272  75.732  1.00 49.83  ? 211 ARG H CG  1 
ATOM   4826 C CD  . ARG C 1 211 ? 31.936  25.489  76.360  1.00 54.96  ? 211 ARG H CD  1 
ATOM   4827 N NE  . ARG C 1 211 ? 33.015  25.156  77.280  1.00 61.72  ? 211 ARG H NE  1 
ATOM   4828 C CZ  . ARG C 1 211 ? 34.253  25.651  77.243  1.00 68.10  ? 211 ARG H CZ  1 
ATOM   4829 N NH1 . ARG C 1 211 ? 34.645  26.444  76.256  1.00 64.66  ? 211 ARG H NH1 1 
ATOM   4830 N NH2 . ARG C 1 211 ? 35.110  25.326  78.198  1.00 71.80  ? 211 ARG H NH2 1 
ATOM   4831 N N   . VAL C 1 212 ? 29.434  21.443  74.786  1.00 27.96  ? 212 VAL H N   1 
ATOM   4832 C CA  . VAL C 1 212 ? 28.788  20.355  75.506  1.00 34.26  ? 212 VAL H CA  1 
ATOM   4833 C C   . VAL C 1 212 ? 29.622  20.035  76.743  1.00 34.89  ? 212 VAL H C   1 
ATOM   4834 O O   . VAL C 1 212 ? 30.776  19.639  76.625  1.00 36.45  ? 212 VAL H O   1 
ATOM   4835 C CB  . VAL C 1 212 ? 28.590  19.104  74.620  1.00 34.63  ? 212 VAL H CB  1 
ATOM   4836 C CG1 . VAL C 1 212 ? 27.885  17.979  75.368  1.00 31.72  ? 212 VAL H CG1 1 
ATOM   4837 C CG2 . VAL C 1 212 ? 27.843  19.432  73.329  1.00 35.03  ? 212 VAL H CG2 1 
ATOM   4838 N N   . GLU C 1 213 ? 29.029  20.224  77.930  1.00 42.31  ? 213 GLU H N   1 
ATOM   4839 C CA  . GLU C 1 213 ? 29.745  20.081  79.191  1.00 48.18  ? 213 GLU H CA  1 
ATOM   4840 C C   . GLU C 1 213 ? 29.034  19.056  80.062  1.00 48.61  ? 213 GLU H C   1 
ATOM   4841 O O   . GLU C 1 213 ? 27.815  18.935  79.970  1.00 46.07  ? 213 GLU H O   1 
ATOM   4842 C CB  . GLU C 1 213 ? 29.812  21.421  79.921  1.00 51.11  ? 213 GLU H CB  1 
ATOM   4843 C CG  . GLU C 1 213 ? 31.026  22.246  79.535  1.00 61.40  ? 213 GLU H CG  1 
ATOM   4844 C CD  . GLU C 1 213 ? 30.883  23.743  79.757  1.00 69.17  ? 213 GLU H CD  1 
ATOM   4845 O OE1 . GLU C 1 213 ? 29.777  24.189  80.156  1.00 67.56  ? 213 GLU H OE1 1 
ATOM   4846 O OE2 . GLU C 1 213 ? 31.877  24.466  79.513  1.00 76.26  ? 213 GLU H OE2 1 
ATOM   4847 N N   . PRO C 1 214 ? 29.758  18.333  80.958  1.00 58.75  ? 214 PRO H N   1 
ATOM   4848 C CA  . PRO C 1 214 ? 29.107  17.460  81.941  1.00 56.48  ? 214 PRO H CA  1 
ATOM   4849 C C   . PRO C 1 214 ? 28.245  18.335  82.846  1.00 61.48  ? 214 PRO H C   1 
ATOM   4850 O O   . PRO C 1 214 ? 28.590  19.490  83.077  1.00 67.07  ? 214 PRO H O   1 
ATOM   4851 C CB  . PRO C 1 214 ? 30.235  16.777  82.736  1.00 55.77  ? 214 PRO H CB  1 
ATOM   4852 C CG  . PRO C 1 214 ? 31.552  17.256  82.101  1.00 54.42  ? 214 PRO H CG  1 
ATOM   4853 C CD  . PRO C 1 214 ? 31.224  18.375  81.126  1.00 53.42  ? 214 PRO H CD  1 
ATOM   4854 N N   . LYS C 1 215 ? 27.110  17.803  83.321  1.00 73.36  ? 215 LYS H N   1 
ATOM   4855 C CA  . LYS C 1 215 ? 26.249  18.543  84.233  1.00 77.39  ? 215 LYS H CA  1 
ATOM   4856 C C   . LYS C 1 215 ? 25.822  17.615  85.379  1.00 82.98  ? 215 LYS H C   1 
ATOM   4857 O O   . LYS C 1 215 ? 26.040  18.002  86.546  1.00 85.80  ? 215 LYS H O   1 
ATOM   4858 C CB  . LYS C 1 215 ? 25.033  19.115  83.493  1.00 75.82  ? 215 LYS H CB  1 
ATOM   4859 C CG  . LYS C 1 215 ? 24.711  20.583  83.768  1.00 79.16  ? 215 LYS H CG  1 
ATOM   4860 C CD  . LYS C 1 215 ? 24.822  21.022  85.221  1.00 76.85  ? 215 LYS H CD  1 
ATOM   4861 C CE  . LYS C 1 215 ? 24.575  22.506  85.402  1.00 78.13  ? 215 LYS H CE  1 
ATOM   4862 N NZ  . LYS C 1 215 ? 24.719  22.922  86.820  1.00 75.30  ? 215 LYS H NZ  1 
ATOM   4863 N N   . ASP D 2 1   ? 6.600   -8.128  33.139  1.00 54.74  ? 1   ASP L N   1 
ATOM   4864 C CA  . ASP D 2 1   ? 6.190   -9.469  33.627  1.00 47.62  ? 1   ASP L CA  1 
ATOM   4865 C C   . ASP D 2 1   ? 7.396   -10.407 33.798  1.00 40.12  ? 1   ASP L C   1 
ATOM   4866 O O   . ASP D 2 1   ? 7.222   -11.543 34.227  1.00 45.19  ? 1   ASP L O   1 
ATOM   4867 C CB  . ASP D 2 1   ? 5.079   -10.030 32.729  1.00 54.54  ? 1   ASP L CB  1 
ATOM   4868 C CG  . ASP D 2 1   ? 5.549   -10.703 31.452  1.00 61.39  ? 1   ASP L CG  1 
ATOM   4869 O OD1 . ASP D 2 1   ? 6.544   -10.221 30.861  1.00 69.36  ? 1   ASP L OD1 1 
ATOM   4870 O OD2 . ASP D 2 1   ? 4.886   -11.686 31.031  1.00 70.98  ? 1   ASP L OD2 1 
ATOM   4871 N N   . ILE D 2 2   ? 8.624   -9.979  33.469  1.00 31.38  ? 2   ILE L N   1 
ATOM   4872 C CA  . ILE D 2 2   ? 9.794   -10.691 33.946  1.00 25.62  ? 2   ILE L CA  1 
ATOM   4873 C C   . ILE D 2 2   ? 10.170  -10.180 35.338  1.00 24.27  ? 2   ILE L C   1 
ATOM   4874 O O   . ILE D 2 2   ? 10.567  -9.023  35.475  1.00 23.97  ? 2   ILE L O   1 
ATOM   4875 C CB  . ILE D 2 2   ? 10.991  -10.610 32.989  1.00 24.30  ? 2   ILE L CB  1 
ATOM   4876 C CG1 . ILE D 2 2   ? 10.638  -11.069 31.569  1.00 25.79  ? 2   ILE L CG1 1 
ATOM   4877 C CG2 . ILE D 2 2   ? 12.130  -11.436 33.576  1.00 22.74  ? 2   ILE L CG2 1 
ATOM   4878 C CD1 . ILE D 2 2   ? 11.852  -11.227 30.642  1.00 25.39  ? 2   ILE L CD1 1 
ATOM   4879 N N   . VAL D 2 3   ? 10.100  -11.087 36.325  1.00 20.12  ? 3   VAL L N   1 
ATOM   4880 C CA  . VAL D 2 3   ? 10.376  -10.826 37.723  1.00 21.76  ? 3   VAL L CA  1 
ATOM   4881 C C   . VAL D 2 3   ? 11.819  -11.231 38.007  1.00 20.51  ? 3   VAL L C   1 
ATOM   4882 O O   . VAL D 2 3   ? 12.286  -12.251 37.531  1.00 23.32  ? 3   VAL L O   1 
ATOM   4883 C CB  . VAL D 2 3   ? 9.364   -11.559 38.632  1.00 24.43  ? 3   VAL L CB  1 
ATOM   4884 C CG1 . VAL D 2 3   ? 9.686   -11.462 40.130  1.00 24.01  ? 3   VAL L CG1 1 
ATOM   4885 C CG2 . VAL D 2 3   ? 7.948   -11.064 38.367  1.00 26.54  ? 3   VAL L CG2 1 
ATOM   4886 N N   . MET D 2 4   ? 12.538  -10.415 38.774  1.00 20.40  ? 4   MET L N   1 
ATOM   4887 C CA  . MET D 2 4   ? 13.929  -10.692 39.085  1.00 21.17  ? 4   MET L CA  1 
ATOM   4888 C C   . MET D 2 4   ? 14.030  -10.847 40.594  1.00 22.96  ? 4   MET L C   1 
ATOM   4889 O O   . MET D 2 4   ? 13.504  -9.996  41.302  1.00 24.02  ? 4   MET L O   1 
ATOM   4890 C CB  . MET D 2 4   ? 14.810  -9.525  38.640  1.00 20.80  ? 4   MET L CB  1 
ATOM   4891 C CG  . MET D 2 4   ? 14.652  -9.207  37.205  1.00 20.57  ? 4   MET L CG  1 
ATOM   4892 S SD  . MET D 2 4   ? 15.217  -10.559 36.145  1.00 20.56  ? 4   MET L SD  1 
ATOM   4893 C CE  . MET D 2 4   ? 16.977  -10.256 36.222  1.00 21.27  ? 4   MET L CE  1 
ATOM   4894 N N   . THR D 2 5   ? 14.598  -11.968 41.070  1.00 21.06  ? 5   THR L N   1 
ATOM   4895 C CA  . THR D 2 5   ? 14.734  -12.217 42.495  1.00 21.05  ? 5   THR L CA  1 
ATOM   4896 C C   . THR D 2 5   ? 16.206  -12.375 42.813  1.00 20.22  ? 5   THR L C   1 
ATOM   4897 O O   . THR D 2 5   ? 16.807  -13.318 42.327  1.00 18.66  ? 5   THR L O   1 
ATOM   4898 C CB  . THR D 2 5   ? 14.059  -13.523 42.936  1.00 24.71  ? 5   THR L CB  1 
ATOM   4899 O OG1 . THR D 2 5   ? 12.773  -13.604 42.340  1.00 24.86  ? 5   THR L OG1 1 
ATOM   4900 C CG2 . THR D 2 5   ? 13.909  -13.639 44.439  1.00 25.73  ? 5   THR L CG2 1 
ATOM   4901 N N   . GLN D 2 6   ? 16.773  -11.438 43.585  1.00 22.36  ? 6   GLN L N   1 
ATOM   4902 C CA  . GLN D 2 6   ? 18.162  -11.510 44.018  1.00 23.99  ? 6   GLN L CA  1 
ATOM   4903 C C   . GLN D 2 6   ? 18.244  -12.204 45.376  1.00 23.73  ? 6   GLN L C   1 
ATOM   4904 O O   . GLN D 2 6   ? 17.335  -12.096 46.174  1.00 24.96  ? 6   GLN L O   1 
ATOM   4905 C CB  . GLN D 2 6   ? 18.762  -10.113 44.214  1.00 24.09  ? 6   GLN L CB  1 
ATOM   4906 C CG  . GLN D 2 6   ? 19.282  -9.505  42.947  1.00 21.06  ? 6   GLN L CG  1 
ATOM   4907 C CD  . GLN D 2 6   ? 19.785  -8.102  43.146  1.00 18.44  ? 6   GLN L CD  1 
ATOM   4908 O OE1 . GLN D 2 6   ? 19.221  -7.143  42.637  1.00 18.82  ? 6   GLN L OE1 1 
ATOM   4909 N NE2 . GLN D 2 6   ? 20.884  -7.970  43.850  1.00 19.02  ? 6   GLN L NE2 1 
ATOM   4910 N N   . SER D 2 7   ? 19.351  -12.880 45.647  1.00 25.63  ? 7   SER L N   1 
ATOM   4911 C CA  . SER D 2 7   ? 19.572  -13.423 46.973  1.00 30.67  ? 7   SER L CA  1 
ATOM   4912 C C   . SER D 2 7   ? 21.073  -13.468 47.260  1.00 28.74  ? 7   SER L C   1 
ATOM   4913 O O   . SER D 2 7   ? 21.894  -13.572 46.362  1.00 28.83  ? 7   SER L O   1 
ATOM   4914 C CB  . SER D 2 7   ? 18.919  -14.776 47.157  1.00 30.27  ? 7   SER L CB  1 
ATOM   4915 O OG  . SER D 2 7   ? 19.439  -15.695 46.209  1.00 33.97  ? 7   SER L OG  1 
ATOM   4916 N N   . PRO D 2 8   ? 21.487  -13.277 48.529  1.00 28.24  ? 8   PRO L N   1 
ATOM   4917 C CA  . PRO D 2 8   ? 20.561  -12.888 49.601  1.00 25.59  ? 8   PRO L CA  1 
ATOM   4918 C C   . PRO D 2 8   ? 20.286  -11.391 49.479  1.00 26.76  ? 8   PRO L C   1 
ATOM   4919 O O   . PRO D 2 8   ? 20.849  -10.753 48.572  1.00 27.37  ? 8   PRO L O   1 
ATOM   4920 C CB  . PRO D 2 8   ? 21.356  -13.250 50.856  1.00 25.62  ? 8   PRO L CB  1 
ATOM   4921 C CG  . PRO D 2 8   ? 22.810  -12.994 50.437  1.00 26.57  ? 8   PRO L CG  1 
ATOM   4922 C CD  . PRO D 2 8   ? 22.889  -13.325 48.959  1.00 26.35  ? 8   PRO L CD  1 
ATOM   4923 N N   . ASP D 2 9   ? 19.456  -10.867 50.400  1.00 25.21  ? 9   ASP L N   1 
ATOM   4924 C CA  . ASP D 2 9   ? 19.166  -9.443  50.528  1.00 27.78  ? 9   ASP L CA  1 
ATOM   4925 C C   . ASP D 2 9   ? 20.375  -8.693  51.064  1.00 25.71  ? 9   ASP L C   1 
ATOM   4926 O O   . ASP D 2 9   ? 20.579  -7.520  50.780  1.00 23.00  ? 9   ASP L O   1 
ATOM   4927 C CB  . ASP D 2 9   ? 18.096  -9.147  51.581  1.00 32.05  ? 9   ASP L CB  1 
ATOM   4928 C CG  . ASP D 2 9   ? 16.674  -9.417  51.138  1.00 39.38  ? 9   ASP L CG  1 
ATOM   4929 O OD1 . ASP D 2 9   ? 16.490  -9.905  49.997  1.00 43.54  ? 9   ASP L OD1 1 
ATOM   4930 O OD2 . ASP D 2 9   ? 15.757  -9.091  51.935  1.00 48.62  ? 9   ASP L OD2 1 
ATOM   4931 N N   . SER D 2 10  ? 21.161  -9.360  51.900  1.00 25.74  ? 10  SER L N   1 
ATOM   4932 C CA  . SER D 2 10  ? 22.399  -8.752  52.336  1.00 26.65  ? 10  SER L CA  1 
ATOM   4933 C C   . SER D 2 10  ? 23.397  -9.843  52.649  1.00 25.51  ? 10  SER L C   1 
ATOM   4934 O O   . SER D 2 10  ? 23.004  -10.972 52.920  1.00 28.46  ? 10  SER L O   1 
ATOM   4935 C CB  . SER D 2 10  ? 22.175  -7.857  53.491  1.00 30.17  ? 10  SER L CB  1 
ATOM   4936 O OG  . SER D 2 10  ? 21.896  -8.623  54.631  1.00 32.63  ? 10  SER L OG  1 
ATOM   4937 N N   . LEU D 2 11  ? 24.668  -9.458  52.588  1.00 24.11  ? 11  LEU L N   1 
ATOM   4938 C CA  . LEU D 2 11  ? 25.787  -10.367 52.541  1.00 23.77  ? 11  LEU L CA  1 
ATOM   4939 C C   . LEU D 2 11  ? 26.962  -9.709  53.260  1.00 24.40  ? 11  LEU L C   1 
ATOM   4940 O O   . LEU D 2 11  ? 27.315  -8.568  52.989  1.00 26.04  ? 11  LEU L O   1 
ATOM   4941 C CB  . LEU D 2 11  ? 26.124  -10.639 51.069  1.00 26.95  ? 11  LEU L CB  1 
ATOM   4942 C CG  . LEU D 2 11  ? 27.358  -11.510 50.852  1.00 29.59  ? 11  LEU L CG  1 
ATOM   4943 C CD1 . LEU D 2 11  ? 27.108  -12.912 51.365  1.00 32.87  ? 11  LEU L CD1 1 
ATOM   4944 C CD2 . LEU D 2 11  ? 27.763  -11.577 49.392  1.00 31.09  ? 11  LEU L CD2 1 
ATOM   4945 N N   . ALA D 2 12  ? 27.555  -10.448 54.192  1.00 25.90  ? 12  ALA L N   1 
ATOM   4946 C CA  . ALA D 2 12  ? 28.691  -10.007 54.972  1.00 27.39  ? 12  ALA L CA  1 
ATOM   4947 C C   . ALA D 2 12  ? 29.892  -10.840 54.524  1.00 26.25  ? 12  ALA L C   1 
ATOM   4948 O O   . ALA D 2 12  ? 29.823  -12.053 54.580  1.00 23.99  ? 12  ALA L O   1 
ATOM   4949 C CB  . ALA D 2 12  ? 28.363  -10.194 56.445  1.00 25.72  ? 12  ALA L CB  1 
ATOM   4950 N N   . VAL D 2 13  ? 30.971  -10.196 54.069  1.00 25.53  ? 13  VAL L N   1 
ATOM   4951 C CA  . VAL D 2 13  ? 32.114  -10.915 53.541  1.00 28.43  ? 13  VAL L CA  1 
ATOM   4952 C C   . VAL D 2 13  ? 33.390  -10.270 54.069  1.00 26.98  ? 13  VAL L C   1 
ATOM   4953 O O   . VAL D 2 13  ? 33.439  -9.048  54.278  1.00 23.39  ? 13  VAL L O   1 
ATOM   4954 C CB  . VAL D 2 13  ? 32.090  -10.934 52.000  1.00 32.75  ? 13  VAL L CB  1 
ATOM   4955 C CG1 . VAL D 2 13  ? 33.297  -11.671 51.426  1.00 36.11  ? 13  VAL L CG1 1 
ATOM   4956 C CG2 . VAL D 2 13  ? 30.820  -11.558 51.463  1.00 33.60  ? 13  VAL L CG2 1 
ATOM   4957 N N   . SER D 2 14  ? 34.420  -11.095 54.301  1.00 26.93  ? 14  SER L N   1 
ATOM   4958 C CA  . SER D 2 14  ? 35.634  -10.614 54.960  1.00 28.18  ? 14  SER L CA  1 
ATOM   4959 C C   . SER D 2 14  ? 36.557  -10.052 53.900  1.00 25.07  ? 14  SER L C   1 
ATOM   4960 O O   . SER D 2 14  ? 36.531  -10.508 52.770  1.00 25.58  ? 14  SER L O   1 
ATOM   4961 C CB  . SER D 2 14  ? 36.338  -11.668 55.784  1.00 30.14  ? 14  SER L CB  1 
ATOM   4962 O OG  . SER D 2 14  ? 35.408  -12.439 56.554  1.00 34.23  ? 14  SER L OG  1 
ATOM   4963 N N   . LEU D 2 15  ? 37.328  -9.042  54.266  1.00 26.45  ? 15  LEU L N   1 
ATOM   4964 C CA  . LEU D 2 15  ? 38.327  -8.487  53.370  1.00 29.17  ? 15  LEU L CA  1 
ATOM   4965 C C   . LEU D 2 15  ? 39.159  -9.624  52.779  1.00 25.97  ? 15  LEU L C   1 
ATOM   4966 O O   . LEU D 2 15  ? 39.577  -10.491 53.525  1.00 26.35  ? 15  LEU L O   1 
ATOM   4967 C CB  . LEU D 2 15  ? 39.184  -7.508  54.183  1.00 32.00  ? 15  LEU L CB  1 
ATOM   4968 C CG  . LEU D 2 15  ? 39.050  -6.015  53.869  1.00 38.42  ? 15  LEU L CG  1 
ATOM   4969 C CD1 . LEU D 2 15  ? 37.771  -5.666  53.129  1.00 38.67  ? 15  LEU L CD1 1 
ATOM   4970 C CD2 . LEU D 2 15  ? 39.141  -5.189  55.152  1.00 40.76  ? 15  LEU L CD2 1 
ATOM   4971 N N   . GLY D 2 16  ? 39.371  -9.627  51.454  1.00 27.37  ? 16  GLY L N   1 
ATOM   4972 C CA  . GLY D 2 16  ? 40.211  -10.619 50.789  1.00 28.06  ? 16  GLY L CA  1 
ATOM   4973 C C   . GLY D 2 16  ? 39.491  -11.943 50.496  1.00 31.36  ? 16  GLY L C   1 
ATOM   4974 O O   . GLY D 2 16  ? 40.089  -12.849 49.922  1.00 32.07  ? 16  GLY L O   1 
ATOM   4975 N N   . GLU D 2 17  ? 38.212  -12.078 50.878  1.00 29.71  ? 17  GLU L N   1 
ATOM   4976 C CA  . GLU D 2 17  ? 37.466  -13.297 50.582  1.00 32.67  ? 17  GLU L CA  1 
ATOM   4977 C C   . GLU D 2 17  ? 36.495  -13.070 49.420  1.00 27.97  ? 17  GLU L C   1 
ATOM   4978 O O   . GLU D 2 17  ? 36.339  -11.949 48.937  1.00 26.15  ? 17  GLU L O   1 
ATOM   4979 C CB  . GLU D 2 17  ? 36.721  -13.795 51.818  1.00 37.44  ? 17  GLU L CB  1 
ATOM   4980 C CG  . GLU D 2 17  ? 37.646  -14.410 52.856  1.00 47.83  ? 17  GLU L CG  1 
ATOM   4981 C CD  . GLU D 2 17  ? 36.912  -15.007 54.046  1.00 57.21  ? 17  GLU L CD  1 
ATOM   4982 O OE1 . GLU D 2 17  ? 36.033  -14.315 54.614  1.00 66.74  ? 17  GLU L OE1 1 
ATOM   4983 O OE2 . GLU D 2 17  ? 37.206  -16.169 54.400  1.00 73.10  ? 17  GLU L OE2 1 
ATOM   4984 N N   . ARG D 2 18  ? 35.865  -14.166 48.995  1.00 27.01  ? 18  ARG L N   1 
ATOM   4985 C CA  . ARG D 2 18  ? 35.011  -14.238 47.815  1.00 30.83  ? 18  ARG L CA  1 
ATOM   4986 C C   . ARG D 2 18  ? 33.557  -13.909 48.178  1.00 29.36  ? 18  ARG L C   1 
ATOM   4987 O O   . ARG D 2 18  ? 33.022  -14.444 49.143  1.00 30.20  ? 18  ARG L O   1 
ATOM   4988 C CB  . ARG D 2 18  ? 35.134  -15.637 47.201  1.00 33.46  ? 18  ARG L CB  1 
ATOM   4989 C CG  . ARG D 2 18  ? 34.089  -15.980 46.143  1.00 38.82  ? 18  ARG L CG  1 
ATOM   4990 C CD  . ARG D 2 18  ? 34.302  -17.344 45.500  1.00 43.87  ? 18  ARG L CD  1 
ATOM   4991 N NE  . ARG D 2 18  ? 35.469  -17.270 44.624  1.00 50.60  ? 18  ARG L NE  1 
ATOM   4992 C CZ  . ARG D 2 18  ? 35.441  -17.344 43.291  1.00 57.13  ? 18  ARG L CZ  1 
ATOM   4993 N NH1 . ARG D 2 18  ? 34.457  -17.967 42.656  1.00 52.61  ? 18  ARG L NH1 1 
ATOM   4994 N NH2 . ARG D 2 18  ? 36.451  -16.845 42.595  1.00 57.76  ? 18  ARG L NH2 1 
ATOM   4995 N N   . ALA D 2 19  ? 32.919  -13.021 47.401  1.00 27.31  ? 19  ALA L N   1 
ATOM   4996 C CA  . ALA D 2 19  ? 31.502  -12.730 47.566  1.00 27.85  ? 19  ALA L CA  1 
ATOM   4997 C C   . ALA D 2 19  ? 30.742  -13.271 46.369  1.00 25.76  ? 19  ALA L C   1 
ATOM   4998 O O   . ALA D 2 19  ? 31.182  -13.051 45.253  1.00 23.76  ? 19  ALA L O   1 
ATOM   4999 C CB  . ALA D 2 19  ? 31.269  -11.245 47.672  1.00 28.29  ? 19  ALA L CB  1 
ATOM   5000 N N   . THR D 2 20  ? 29.579  -13.887 46.630  1.00 24.21  ? 20  THR L N   1 
ATOM   5001 C CA  . THR D 2 20  ? 28.711  -14.422 45.597  1.00 24.78  ? 20  THR L CA  1 
ATOM   5002 C C   . THR D 2 20  ? 27.300  -13.875 45.821  1.00 23.52  ? 20  THR L C   1 
ATOM   5003 O O   . THR D 2 20  ? 26.745  -14.035 46.901  1.00 25.79  ? 20  THR L O   1 
ATOM   5004 C CB  . THR D 2 20  ? 28.726  -15.961 45.671  1.00 28.77  ? 20  THR L CB  1 
ATOM   5005 O OG1 . THR D 2 20  ? 29.925  -16.505 45.101  1.00 28.71  ? 20  THR L OG1 1 
ATOM   5006 C CG2 . THR D 2 20  ? 27.540  -16.569 44.964  1.00 31.61  ? 20  THR L CG2 1 
ATOM   5007 N N   . ILE D 2 21  ? 26.716  -13.264 44.794  1.00 21.94  ? 21  ILE L N   1 
ATOM   5008 C CA  . ILE D 2 21  ? 25.363  -12.737 44.827  1.00 22.41  ? 21  ILE L CA  1 
ATOM   5009 C C   . ILE D 2 21  ? 24.615  -13.383 43.670  1.00 19.32  ? 21  ILE L C   1 
ATOM   5010 O O   . ILE D 2 21  ? 25.141  -13.362 42.563  1.00 15.85  ? 21  ILE L O   1 
ATOM   5011 C CB  . ILE D 2 21  ? 25.348  -11.206 44.636  1.00 24.95  ? 21  ILE L CB  1 
ATOM   5012 C CG1 . ILE D 2 21  ? 26.137  -10.474 45.709  1.00 29.60  ? 21  ILE L CG1 1 
ATOM   5013 C CG2 . ILE D 2 21  ? 23.919  -10.698 44.533  1.00 29.01  ? 21  ILE L CG2 1 
ATOM   5014 C CD1 . ILE D 2 21  ? 26.397  -9.029  45.349  1.00 32.80  ? 21  ILE L CD1 1 
ATOM   5015 N N   . ASN D 2 22  ? 23.381  -13.853 43.923  1.00 19.47  ? 22  ASN L N   1 
ATOM   5016 C CA  . ASN D 2 22  ? 22.622  -14.554 42.906  1.00 22.41  ? 22  ASN L CA  1 
ATOM   5017 C C   . ASN D 2 22  ? 21.430  -13.712 42.434  1.00 21.77  ? 22  ASN L C   1 
ATOM   5018 O O   . ASN D 2 22  ? 20.894  -12.896 43.161  1.00 18.35  ? 22  ASN L O   1 
ATOM   5019 C CB  . ASN D 2 22  ? 22.129  -15.925 43.388  1.00 26.10  ? 22  ASN L CB  1 
ATOM   5020 C CG  . ASN D 2 22  ? 23.248  -16.879 43.775  1.00 29.02  ? 22  ASN L CG  1 
ATOM   5021 O OD1 . ASN D 2 22  ? 23.264  -17.384 44.886  1.00 35.56  ? 22  ASN L OD1 1 
ATOM   5022 N ND2 . ASN D 2 22  ? 24.177  -17.149 42.880  1.00 30.10  ? 22  ASN L ND2 1 
ATOM   5023 N N   . CYS D 2 23  ? 20.990  -14.016 41.214  1.00 20.62  ? 23  CYS L N   1 
ATOM   5024 C CA  . CYS D 2 23  ? 19.822  -13.433 40.610  1.00 23.42  ? 23  CYS L CA  1 
ATOM   5025 C C   . CYS D 2 23  ? 19.090  -14.544 39.863  1.00 20.87  ? 23  CYS L C   1 
ATOM   5026 O O   . CYS D 2 23  ? 19.717  -15.218 39.056  1.00 19.51  ? 23  CYS L O   1 
ATOM   5027 C CB  . CYS D 2 23  ? 20.292  -12.299 39.696  1.00 27.62  ? 23  CYS L CB  1 
ATOM   5028 S SG  . CYS D 2 23  ? 18.962  -11.401 38.881  1.00 36.54  ? 23  CYS L SG  1 
ATOM   5029 N N   . LYS D 2 24  ? 17.785  -14.702 40.116  1.00 20.60  ? 24  LYS L N   1 
ATOM   5030 C CA  . LYS D 2 24  ? 16.932  -15.619 39.371  1.00 22.41  ? 24  LYS L CA  1 
ATOM   5031 C C   . LYS D 2 24  ? 15.846  -14.848 38.612  1.00 20.83  ? 24  LYS L C   1 
ATOM   5032 O O   . LYS D 2 24  ? 15.076  -14.112 39.204  1.00 23.90  ? 24  LYS L O   1 
ATOM   5033 C CB  . LYS D 2 24  ? 16.269  -16.620 40.321  1.00 25.94  ? 24  LYS L CB  1 
ATOM   5034 C CG  . LYS D 2 24  ? 15.303  -17.587 39.636  1.00 32.26  ? 24  LYS L CG  1 
ATOM   5035 C CD  . LYS D 2 24  ? 14.791  -18.713 40.511  1.00 34.50  ? 24  LYS L CD  1 
ATOM   5036 C CE  . LYS D 2 24  ? 15.697  -19.925 40.467  1.00 39.33  ? 24  LYS L CE  1 
ATOM   5037 N NZ  . LYS D 2 24  ? 15.410  -20.815 39.312  1.00 38.23  ? 24  LYS L NZ  1 
ATOM   5038 N N   . SER D 2 25  ? 15.748  -15.025 37.300  1.00 18.68  ? 25  SER L N   1 
ATOM   5039 C CA  . SER D 2 25  ? 14.685  -14.380 36.543  1.00 19.06  ? 25  SER L CA  1 
ATOM   5040 C C   . SER D 2 25  ? 13.537  -15.370 36.338  1.00 19.88  ? 25  SER L C   1 
ATOM   5041 O O   . SER D 2 25  ? 13.773  -16.560 36.240  1.00 18.37  ? 25  SER L O   1 
ATOM   5042 C CB  . SER D 2 25  ? 15.194  -13.822 35.246  1.00 20.09  ? 25  SER L CB  1 
ATOM   5043 O OG  . SER D 2 25  ? 15.871  -14.797 34.465  1.00 21.91  ? 25  SER L OG  1 
ATOM   5044 N N   . SER D 2 26  ? 12.299  -14.872 36.367  1.00 20.16  ? 26  SER L N   1 
ATOM   5045 C CA  . SER D 2 26  ? 11.120  -15.706 36.291  1.00 23.00  ? 26  SER L CA  1 
ATOM   5046 C C   . SER D 2 26  ? 10.944  -16.272 34.887  1.00 23.65  ? 26  SER L C   1 
ATOM   5047 O O   . SER D 2 26  ? 10.179  -17.204 34.718  1.00 23.08  ? 26  SER L O   1 
ATOM   5048 C CB  . SER D 2 26  ? 9.886   -14.932 36.699  1.00 24.47  ? 26  SER L CB  1 
ATOM   5049 O OG  . SER D 2 26  ? 9.627   -13.912 35.754  1.00 23.15  ? 26  SER L OG  1 
ATOM   5050 N N   . GLN D 2 27  ? 11.580  -15.653 33.885  1.00 24.82  ? 27  GLN L N   1 
ATOM   5051 C CA  . GLN D 2 27  ? 11.612  -16.190 32.534  1.00 23.47  ? 27  GLN L CA  1 
ATOM   5052 C C   . GLN D 2 27  ? 13.037  -16.025 32.038  1.00 21.55  ? 27  GLN L C   1 
ATOM   5053 O O   . GLN D 2 27  ? 13.777  -15.196 32.569  1.00 20.55  ? 27  GLN L O   1 
ATOM   5054 C CB  . GLN D 2 27  ? 10.699  -15.446 31.546  1.00 27.50  ? 27  GLN L CB  1 
ATOM   5055 C CG  . GLN D 2 27  ? 9.284   -15.172 32.041  1.00 32.42  ? 27  GLN L CG  1 
ATOM   5056 C CD  . GLN D 2 27  ? 8.544   -14.269 31.075  1.00 40.27  ? 27  GLN L CD  1 
ATOM   5057 O OE1 . GLN D 2 27  ? 8.584   -14.467 29.861  1.00 48.83  ? 27  GLN L OE1 1 
ATOM   5058 N NE2 . GLN D 2 27  ? 7.874   -13.245 31.586  1.00 41.47  ? 27  GLN L NE2 1 
ATOM   5059 N N   . SER D 2 28  ? 13.393  -16.844 31.050  1.00 17.63  ? 28  SER L N   1 
ATOM   5060 C CA  . SER D 2 28  ? 14.686  -16.774 30.412  1.00 18.59  ? 28  SER L CA  1 
ATOM   5061 C C   . SER D 2 28  ? 14.918  -15.387 29.806  1.00 17.33  ? 28  SER L C   1 
ATOM   5062 O O   . SER D 2 28  ? 14.024  -14.795 29.224  1.00 18.07  ? 28  SER L O   1 
ATOM   5063 C CB  . SER D 2 28  ? 14.817  -17.850 29.360  1.00 17.84  ? 28  SER L CB  1 
ATOM   5064 O OG  . SER D 2 28  ? 16.046  -17.706 28.686  1.00 16.52  ? 28  SER L OG  1 
ATOM   5065 N N   . VAL D 2 29  ? 16.147  -14.895 29.936  1.00 18.61  ? 29  VAL L N   1 
ATOM   5066 C CA  . VAL D 2 29  ? 16.555  -13.618 29.372  1.00 18.54  ? 29  VAL L CA  1 
ATOM   5067 C C   . VAL D 2 29  ? 17.566  -13.842 28.255  1.00 21.43  ? 29  VAL L C   1 
ATOM   5068 O O   . VAL D 2 29  ? 18.279  -12.919 27.874  1.00 21.76  ? 29  VAL L O   1 
ATOM   5069 C CB  . VAL D 2 29  ? 17.100  -12.651 30.441  1.00 16.61  ? 29  VAL L CB  1 
ATOM   5070 C CG1 . VAL D 2 29  ? 16.035  -12.303 31.458  1.00 16.40  ? 29  VAL L CG1 1 
ATOM   5071 C CG2 . VAL D 2 29  ? 18.343  -13.131 31.146  1.00 16.60  ? 29  VAL L CG2 1 
ATOM   5072 N N   . LEU D 2 30  ? 17.649  -15.087 27.782  1.00 21.65  ? 30  LEU L N   1 
ATOM   5073 C CA  . LEU D 2 30  ? 18.547  -15.453 26.704  1.00 23.29  ? 30  LEU L CA  1 
ATOM   5074 C C   . LEU D 2 30  ? 17.762  -15.270 25.414  1.00 19.99  ? 30  LEU L C   1 
ATOM   5075 O O   . LEU D 2 30  ? 16.678  -15.799 25.317  1.00 16.81  ? 30  LEU L O   1 
ATOM   5076 C CB  . LEU D 2 30  ? 18.947  -16.916 26.924  1.00 25.05  ? 30  LEU L CB  1 
ATOM   5077 C CG  . LEU D 2 30  ? 19.896  -17.597 25.942  1.00 25.31  ? 30  LEU L CG  1 
ATOM   5078 C CD1 . LEU D 2 30  ? 19.300  -17.687 24.558  1.00 26.57  ? 30  LEU L CD1 1 
ATOM   5079 C CD2 . LEU D 2 30  ? 21.245  -16.942 25.900  1.00 28.07  ? 30  LEU L CD2 1 
ATOM   5080 N N   . TYR D 2 31  ? 18.303  -14.527 24.447  1.00 19.01  ? 31  TYR L N   1 
ATOM   5081 C CA  . TYR D 2 31  ? 17.625  -14.388 23.174  1.00 19.69  ? 31  TYR L CA  1 
ATOM   5082 C C   . TYR D 2 31  ? 18.175  -15.434 22.216  1.00 19.64  ? 31  TYR L C   1 
ATOM   5083 O O   . TYR D 2 31  ? 19.387  -15.479 22.002  1.00 18.12  ? 31  TYR L O   1 
ATOM   5084 C CB  . TYR D 2 31  ? 17.793  -12.972 22.624  1.00 17.65  ? 31  TYR L CB  1 
ATOM   5085 C CG  . TYR D 2 31  ? 16.744  -12.581 21.607  1.00 17.81  ? 31  TYR L CG  1 
ATOM   5086 C CD1 . TYR D 2 31  ? 15.400  -12.541 21.946  1.00 17.36  ? 31  TYR L CD1 1 
ATOM   5087 C CD2 . TYR D 2 31  ? 17.102  -12.199 20.316  1.00 17.65  ? 31  TYR L CD2 1 
ATOM   5088 C CE1 . TYR D 2 31  ? 14.436  -12.140 21.037  1.00 16.74  ? 31  TYR L CE1 1 
ATOM   5089 C CE2 . TYR D 2 31  ? 16.157  -11.774 19.396  1.00 17.22  ? 31  TYR L CE2 1 
ATOM   5090 C CZ  . TYR D 2 31  ? 14.820  -11.759 19.764  1.00 17.66  ? 31  TYR L CZ  1 
ATOM   5091 O OH  . TYR D 2 31  ? 13.898  -11.363 18.851  1.00 20.76  ? 31  TYR L OH  1 
ATOM   5092 N N   . SER D 2 32  ? 17.275  -16.246 21.634  1.00 20.05  ? 32  SER L N   1 
ATOM   5093 C CA  . SER D 2 32  ? 17.695  -17.492 21.007  1.00 20.74  ? 32  SER L CA  1 
ATOM   5094 C C   . SER D 2 32  ? 18.463  -17.237 19.714  1.00 19.14  ? 32  SER L C   1 
ATOM   5095 O O   . SER D 2 32  ? 19.433  -17.926 19.438  1.00 19.34  ? 32  SER L O   1 
ATOM   5096 C CB  . SER D 2 32  ? 16.529  -18.432 20.812  1.00 20.71  ? 32  SER L CB  1 
ATOM   5097 O OG  . SER D 2 32  ? 15.646  -17.940 19.840  1.00 21.24  ? 32  SER L OG  1 
ATOM   5098 N N   . SER D 2 33  ? 18.039  -16.234 18.954  1.00 19.49  ? 33  SER L N   1 
ATOM   5099 C CA  . SER D 2 33  ? 18.691  -15.771 17.731  1.00 21.19  ? 33  SER L CA  1 
ATOM   5100 C C   . SER D 2 33  ? 20.173  -15.471 17.893  1.00 18.77  ? 33  SER L C   1 
ATOM   5101 O O   . SER D 2 33  ? 20.957  -15.744 17.015  1.00 21.56  ? 33  SER L O   1 
ATOM   5102 C CB  . SER D 2 33  ? 18.046  -14.483 17.279  1.00 23.89  ? 33  SER L CB  1 
ATOM   5103 O OG  . SER D 2 33  ? 16.719  -14.740 16.882  1.00 36.03  ? 33  SER L OG  1 
ATOM   5104 N N   . ASN D 2 34  ? 20.550  -14.743 18.934  1.00 21.34  ? 34  ASN L N   1 
ATOM   5105 C CA  . ASN D 2 34  ? 21.935  -14.291 19.057  1.00 19.80  ? 34  ASN L CA  1 
ATOM   5106 C C   . ASN D 2 34  ? 22.595  -14.944 20.260  1.00 17.59  ? 34  ASN L C   1 
ATOM   5107 O O   . ASN D 2 34  ? 23.776  -14.721 20.445  1.00 19.63  ? 34  ASN L O   1 
ATOM   5108 C CB  . ASN D 2 34  ? 22.059  -12.767 19.114  1.00 19.35  ? 34  ASN L CB  1 
ATOM   5109 C CG  . ASN D 2 34  ? 21.248  -12.166 20.242  1.00 19.56  ? 34  ASN L CG  1 
ATOM   5110 O OD1 . ASN D 2 34  ? 21.150  -12.731 21.333  1.00 18.85  ? 34  ASN L OD1 1 
ATOM   5111 N ND2 . ASN D 2 34  ? 20.587  -11.061 19.959  1.00 20.78  ? 34  ASN L ND2 1 
ATOM   5112 N N   . GLN D 2 35  ? 21.849  -15.768 21.020  1.00 18.53  ? 35  GLN L N   1 
ATOM   5113 C CA  . GLN D 2 35  ? 22.378  -16.557 22.130  1.00 20.79  ? 35  GLN L CA  1 
ATOM   5114 C C   . GLN D 2 35  ? 23.053  -15.673 23.185  1.00 22.12  ? 35  GLN L C   1 
ATOM   5115 O O   . GLN D 2 35  ? 23.881  -16.194 23.927  1.00 21.18  ? 35  GLN L O   1 
ATOM   5116 C CB  . GLN D 2 35  ? 23.418  -17.607 21.685  1.00 23.31  ? 35  GLN L CB  1 
ATOM   5117 C CG  . GLN D 2 35  ? 22.926  -18.600 20.630  1.00 25.31  ? 35  GLN L CG  1 
ATOM   5118 C CD  . GLN D 2 35  ? 24.002  -19.600 20.267  1.00 35.87  ? 35  GLN L CD  1 
ATOM   5119 O OE1 . GLN D 2 35  ? 25.046  -19.271 19.719  1.00 38.57  ? 35  GLN L OE1 1 
ATOM   5120 N NE2 . GLN D 2 35  ? 23.789  -20.857 20.606  1.00 45.60  ? 35  GLN L NE2 1 
ATOM   5121 N N   . MET D 2 36  ? 22.678  -14.376 23.285  1.00 19.88  ? 36  MET L N   1 
ATOM   5122 C CA  . MET D 2 36  ? 23.133  -13.515 24.370  1.00 19.89  ? 36  MET L CA  1 
ATOM   5123 C C   . MET D 2 36  ? 22.096  -13.469 25.495  1.00 18.03  ? 36  MET L C   1 
ATOM   5124 O O   . MET D 2 36  ? 20.905  -13.501 25.229  1.00 19.30  ? 36  MET L O   1 
ATOM   5125 C CB  . MET D 2 36  ? 23.399  -12.101 23.843  1.00 22.05  ? 36  MET L CB  1 
ATOM   5126 C CG  . MET D 2 36  ? 24.512  -12.106 22.803  1.00 24.26  ? 36  MET L CG  1 
ATOM   5127 S SD  . MET D 2 36  ? 25.067  -10.468 22.331  1.00 26.55  ? 36  MET L SD  1 
ATOM   5128 C CE  . MET D 2 36  ? 23.703  -9.963  21.291  1.00 30.26  ? 36  MET L CE  1 
ATOM   5129 N N   . ASN D 2 37  ? 22.567  -13.396 26.747  1.00 16.26  ? 37  ASN L N   1 
ATOM   5130 C CA  . ASN D 2 37  ? 21.745  -13.104 27.907  1.00 16.21  ? 37  ASN L CA  1 
ATOM   5131 C C   . ASN D 2 37  ? 21.624  -11.587 28.129  1.00 16.70  ? 37  ASN L C   1 
ATOM   5132 O O   . ASN D 2 37  ? 22.627  -10.895 28.338  1.00 15.88  ? 37  ASN L O   1 
ATOM   5133 C CB  . ASN D 2 37  ? 22.330  -13.777 29.147  1.00 16.00  ? 37  ASN L CB  1 
ATOM   5134 C CG  . ASN D 2 37  ? 22.078  -15.268 29.146  1.00 16.67  ? 37  ASN L CG  1 
ATOM   5135 O OD1 . ASN D 2 37  ? 20.958  -15.721 29.371  1.00 17.64  ? 37  ASN L OD1 1 
ATOM   5136 N ND2 . ASN D 2 37  ? 23.086  -16.040 28.784  1.00 18.82  ? 37  ASN L ND2 1 
ATOM   5137 N N   . TYR D 2 38  ? 20.373  -11.094 28.173  1.00 15.71  ? 38  TYR L N   1 
ATOM   5138 C CA  . TYR D 2 38  ? 20.089  -9.674  28.316  1.00 15.38  ? 38  TYR L CA  1 
ATOM   5139 C C   . TYR D 2 38  ? 20.105  -9.326  29.801  1.00 17.13  ? 38  TYR L C   1 
ATOM   5140 O O   . TYR D 2 38  ? 19.068  -9.012  30.390  1.00 15.69  ? 38  TYR L O   1 
ATOM   5141 C CB  . TYR D 2 38  ? 18.777  -9.329  27.599  1.00 15.32  ? 38  TYR L CB  1 
ATOM   5142 C CG  . TYR D 2 38  ? 18.936  -9.259  26.110  1.00 14.92  ? 38  TYR L CG  1 
ATOM   5143 C CD1 . TYR D 2 38  ? 19.416  -10.350 25.411  1.00 14.76  ? 38  TYR L CD1 1 
ATOM   5144 C CD2 . TYR D 2 38  ? 18.655  -8.109  25.396  1.00 16.03  ? 38  TYR L CD2 1 
ATOM   5145 C CE1 . TYR D 2 38  ? 19.648  -10.285 24.059  1.00 15.28  ? 38  TYR L CE1 1 
ATOM   5146 C CE2 . TYR D 2 38  ? 18.832  -8.045  24.021  1.00 15.63  ? 38  TYR L CE2 1 
ATOM   5147 C CZ  . TYR D 2 38  ? 19.329  -9.145  23.355  1.00 15.68  ? 38  TYR L CZ  1 
ATOM   5148 O OH  . TYR D 2 38  ? 19.578  -9.179  22.021  1.00 16.77  ? 38  TYR L OH  1 
ATOM   5149 N N   . LEU D 2 39  ? 21.302  -9.425  30.405  1.00 17.83  ? 39  LEU L N   1 
ATOM   5150 C CA  . LEU D 2 39  ? 21.426  -9.321  31.849  1.00 17.18  ? 39  LEU L CA  1 
ATOM   5151 C C   . LEU D 2 39  ? 22.642  -8.487  32.226  1.00 16.25  ? 39  LEU L C   1 
ATOM   5152 O O   . LEU D 2 39  ? 23.726  -8.664  31.686  1.00 15.13  ? 39  LEU L O   1 
ATOM   5153 C CB  . LEU D 2 39  ? 21.509  -10.672 32.567  1.00 18.36  ? 39  LEU L CB  1 
ATOM   5154 C CG  . LEU D 2 39  ? 21.278  -10.471 34.075  1.00 19.92  ? 39  LEU L CG  1 
ATOM   5155 C CD1 . LEU D 2 39  ? 19.958  -11.032 34.554  1.00 19.36  ? 39  LEU L CD1 1 
ATOM   5156 C CD2 . LEU D 2 39  ? 22.454  -10.925 34.903  1.00 20.04  ? 39  LEU L CD2 1 
ATOM   5157 N N   . ALA D 2 40  ? 22.422  -7.554  33.159  1.00 16.60  ? 40  ALA L N   1 
ATOM   5158 C CA  . ALA D 2 40  ? 23.514  -6.715  33.634  1.00 17.73  ? 40  ALA L CA  1 
ATOM   5159 C C   . ALA D 2 40  ? 23.472  -6.642  35.155  1.00 16.31  ? 40  ALA L C   1 
ATOM   5160 O O   . ALA D 2 40  ? 22.453  -6.916  35.783  1.00 18.71  ? 40  ALA L O   1 
ATOM   5161 C CB  . ALA D 2 40  ? 23.456  -5.330  33.005  1.00 17.48  ? 40  ALA L CB  1 
ATOM   5162 N N   . TRP D 2 41  ? 24.622  -6.277  35.707  1.00 15.51  ? 41  TRP L N   1 
ATOM   5163 C CA  . TRP D 2 41  ? 24.833  -6.031  37.116  1.00 14.80  ? 41  TRP L CA  1 
ATOM   5164 C C   . TRP D 2 41  ? 25.358  -4.621  37.328  1.00 13.42  ? 41  TRP L C   1 
ATOM   5165 O O   . TRP D 2 41  ? 26.262  -4.204  36.621  1.00 12.13  ? 41  TRP L O   1 
ATOM   5166 C CB  . TRP D 2 41  ? 25.889  -7.001  37.661  1.00 15.52  ? 41  TRP L CB  1 
ATOM   5167 C CG  . TRP D 2 41  ? 25.462  -8.421  37.711  1.00 14.73  ? 41  TRP L CG  1 
ATOM   5168 C CD1 . TRP D 2 41  ? 25.771  -9.417  36.833  1.00 14.43  ? 41  TRP L CD1 1 
ATOM   5169 C CD2 . TRP D 2 41  ? 24.726  -9.023  38.776  1.00 15.91  ? 41  TRP L CD2 1 
ATOM   5170 N NE1 . TRP D 2 41  ? 25.241  -10.600 37.272  1.00 15.91  ? 41  TRP L NE1 1 
ATOM   5171 C CE2 . TRP D 2 41  ? 24.583  -10.386 38.455  1.00 16.03  ? 41  TRP L CE2 1 
ATOM   5172 C CE3 . TRP D 2 41  ? 24.147  -8.537  39.944  1.00 16.86  ? 41  TRP L CE3 1 
ATOM   5173 C CZ2 . TRP D 2 41  ? 23.929  -11.280 39.295  1.00 16.17  ? 41  TRP L CZ2 1 
ATOM   5174 C CZ3 . TRP D 2 41  ? 23.497  -9.418  40.763  1.00 17.95  ? 41  TRP L CZ3 1 
ATOM   5175 C CH2 . TRP D 2 41  ? 23.388  -10.770 40.440  1.00 16.94  ? 41  TRP L CH2 1 
ATOM   5176 N N   . TYR D 2 42  ? 24.859  -3.985  38.393  1.00 14.80  ? 42  TYR L N   1 
ATOM   5177 C CA  . TYR D 2 42  ? 25.193  -2.619  38.770  1.00 15.52  ? 42  TYR L CA  1 
ATOM   5178 C C   . TYR D 2 42  ? 25.670  -2.599  40.215  1.00 15.17  ? 42  TYR L C   1 
ATOM   5179 O O   . TYR D 2 42  ? 25.172  -3.373  41.052  1.00 14.35  ? 42  TYR L O   1 
ATOM   5180 C CB  . TYR D 2 42  ? 23.973  -1.695  38.637  1.00 14.56  ? 42  TYR L CB  1 
ATOM   5181 C CG  . TYR D 2 42  ? 23.569  -1.482  37.201  1.00 14.62  ? 42  TYR L CG  1 
ATOM   5182 C CD1 . TYR D 2 42  ? 24.120  -0.463  36.441  1.00 13.21  ? 42  TYR L CD1 1 
ATOM   5183 C CD2 . TYR D 2 42  ? 22.685  -2.356  36.580  1.00 15.47  ? 42  TYR L CD2 1 
ATOM   5184 C CE1 . TYR D 2 42  ? 23.789  -0.294  35.108  1.00 13.64  ? 42  TYR L CE1 1 
ATOM   5185 C CE2 . TYR D 2 42  ? 22.352  -2.211  35.237  1.00 15.37  ? 42  TYR L CE2 1 
ATOM   5186 C CZ  . TYR D 2 42  ? 22.902  -1.170  34.500  1.00 14.82  ? 42  TYR L CZ  1 
ATOM   5187 O OH  . TYR D 2 42  ? 22.543  -1.020  33.177  1.00 15.06  ? 42  TYR L OH  1 
ATOM   5188 N N   . GLN D 2 43  ? 26.556  -1.633  40.479  1.00 14.22  ? 43  GLN L N   1 
ATOM   5189 C CA  . GLN D 2 43  ? 26.983  -1.258  41.817  1.00 14.75  ? 43  GLN L CA  1 
ATOM   5190 C C   . GLN D 2 43  ? 26.487  0.148   42.131  1.00 14.99  ? 43  GLN L C   1 
ATOM   5191 O O   . GLN D 2 43  ? 26.689  1.069   41.327  1.00 14.14  ? 43  GLN L O   1 
ATOM   5192 C CB  . GLN D 2 43  ? 28.517  -1.273  41.880  1.00 15.61  ? 43  GLN L CB  1 
ATOM   5193 C CG  . GLN D 2 43  ? 29.114  -0.870  43.222  1.00 17.51  ? 43  GLN L CG  1 
ATOM   5194 C CD  . GLN D 2 43  ? 30.594  -0.587  43.100  1.00 17.65  ? 43  GLN L CD  1 
ATOM   5195 O OE1 . GLN D 2 43  ? 31.015  0.314   42.384  1.00 19.60  ? 43  GLN L OE1 1 
ATOM   5196 N NE2 . GLN D 2 43  ? 31.398  -1.429  43.711  1.00 17.34  ? 43  GLN L NE2 1 
ATOM   5197 N N   . GLN D 2 44  ? 25.937  0.349   43.338  1.00 15.86  ? 44  GLN L N   1 
ATOM   5198 C CA  . GLN D 2 44  ? 25.488  1.682   43.717  1.00 17.24  ? 44  GLN L CA  1 
ATOM   5199 C C   . GLN D 2 44  ? 25.960  2.035   45.123  1.00 17.26  ? 44  GLN L C   1 
ATOM   5200 O O   . GLN D 2 44  ? 25.701  1.302   46.065  1.00 14.98  ? 44  GLN L O   1 
ATOM   5201 C CB  . GLN D 2 44  ? 23.961  1.810   43.679  1.00 17.41  ? 44  GLN L CB  1 
ATOM   5202 C CG  . GLN D 2 44  ? 23.487  3.257   43.823  1.00 16.53  ? 44  GLN L CG  1 
ATOM   5203 C CD  . GLN D 2 44  ? 21.989  3.395   43.707  1.00 16.52  ? 44  GLN L CD  1 
ATOM   5204 O OE1 . GLN D 2 44  ? 21.216  2.507   44.066  1.00 17.90  ? 44  GLN L OE1 1 
ATOM   5205 N NE2 . GLN D 2 44  ? 21.567  4.502   43.149  1.00 16.59  ? 44  GLN L NE2 1 
ATOM   5206 N N   . LYS D 2 45  ? 26.603  3.191   45.244  1.00 17.81  ? 45  LYS L N   1 
ATOM   5207 C CA  . LYS D 2 45  ? 26.950  3.725   46.544  1.00 22.37  ? 45  LYS L CA  1 
ATOM   5208 C C   . LYS D 2 45  ? 26.081  4.947   46.823  1.00 23.35  ? 45  LYS L C   1 
ATOM   5209 O O   . LYS D 2 45  ? 25.529  5.521   45.893  1.00 21.68  ? 45  LYS L O   1 
ATOM   5210 C CB  . LYS D 2 45  ? 28.437  4.081   46.581  1.00 24.79  ? 45  LYS L CB  1 
ATOM   5211 C CG  . LYS D 2 45  ? 29.352  2.871   46.517  1.00 27.08  ? 45  LYS L CG  1 
ATOM   5212 C CD  . LYS D 2 45  ? 30.815  3.181   46.694  1.00 29.50  ? 45  LYS L CD  1 
ATOM   5213 C CE  . LYS D 2 45  ? 31.657  2.204   45.908  1.00 30.65  ? 45  LYS L CE  1 
ATOM   5214 N NZ  . LYS D 2 45  ? 33.073  2.325   46.261  1.00 33.23  ? 45  LYS L NZ  1 
ATOM   5215 N N   . PRO D 2 46  ? 25.949  5.385   48.102  1.00 29.61  ? 46  PRO L N   1 
ATOM   5216 C CA  . PRO D 2 46  ? 25.019  6.467   48.459  1.00 29.81  ? 46  PRO L CA  1 
ATOM   5217 C C   . PRO D 2 46  ? 25.317  7.765   47.709  1.00 28.39  ? 46  PRO L C   1 
ATOM   5218 O O   . PRO D 2 46  ? 26.479  8.073   47.466  1.00 31.64  ? 46  PRO L O   1 
ATOM   5219 C CB  . PRO D 2 46  ? 25.224  6.629   49.977  1.00 29.92  ? 46  PRO L CB  1 
ATOM   5220 C CG  . PRO D 2 46  ? 25.750  5.266   50.420  1.00 31.39  ? 46  PRO L CG  1 
ATOM   5221 C CD  . PRO D 2 46  ? 26.660  4.850   49.280  1.00 29.26  ? 46  PRO L CD  1 
ATOM   5222 N N   . GLY D 2 47  ? 24.267  8.481   47.267  1.00 27.31  ? 47  GLY L N   1 
ATOM   5223 C CA  . GLY D 2 47  ? 24.441  9.787   46.643  1.00 24.22  ? 47  GLY L CA  1 
ATOM   5224 C C   . GLY D 2 47  ? 24.884  9.710   45.185  1.00 26.75  ? 47  GLY L C   1 
ATOM   5225 O O   . GLY D 2 47  ? 25.088  10.755  44.554  1.00 26.22  ? 47  GLY L O   1 
ATOM   5226 N N   . GLN D 2 48  ? 24.977  8.487   44.632  1.00 25.23  ? 48  GLN L N   1 
ATOM   5227 C CA  . GLN D 2 48  ? 25.467  8.286   43.269  1.00 26.53  ? 48  GLN L CA  1 
ATOM   5228 C C   . GLN D 2 48  ? 24.466  7.475   42.436  1.00 20.29  ? 48  GLN L C   1 
ATOM   5229 O O   . GLN D 2 48  ? 23.670  6.687   42.956  1.00 17.77  ? 48  GLN L O   1 
ATOM   5230 C CB  . GLN D 2 48  ? 26.795  7.508   43.263  1.00 30.25  ? 48  GLN L CB  1 
ATOM   5231 C CG  . GLN D 2 48  ? 27.992  8.250   43.847  1.00 32.00  ? 48  GLN L CG  1 
ATOM   5232 C CD  . GLN D 2 48  ? 29.171  7.304   43.956  1.00 34.51  ? 48  GLN L CD  1 
ATOM   5233 O OE1 . GLN D 2 48  ? 29.167  6.199   43.414  1.00 37.32  ? 48  GLN L OE1 1 
ATOM   5234 N NE2 . GLN D 2 48  ? 30.207  7.723   44.663  1.00 33.16  ? 48  GLN L NE2 1 
ATOM   5235 N N   . PRO D 2 49  ? 24.496  7.600   41.098  1.00 17.34  ? 49  PRO L N   1 
ATOM   5236 C CA  . PRO D 2 49  ? 23.785  6.640   40.254  1.00 16.73  ? 49  PRO L CA  1 
ATOM   5237 C C   . PRO D 2 49  ? 24.436  5.255   40.259  1.00 17.85  ? 49  PRO L C   1 
ATOM   5238 O O   . PRO D 2 49  ? 25.615  5.095   40.549  1.00 19.48  ? 49  PRO L O   1 
ATOM   5239 C CB  . PRO D 2 49  ? 23.864  7.286   38.876  1.00 16.43  ? 49  PRO L CB  1 
ATOM   5240 C CG  . PRO D 2 49  ? 25.151  8.118   38.925  1.00 15.16  ? 49  PRO L CG  1 
ATOM   5241 C CD  . PRO D 2 49  ? 25.144  8.678   40.321  1.00 15.70  ? 49  PRO L CD  1 
ATOM   5242 N N   . PRO D 2 50  ? 23.686  4.206   39.892  1.00 17.13  ? 50  PRO L N   1 
ATOM   5243 C CA  . PRO D 2 50  ? 24.252  2.865   39.778  1.00 17.16  ? 50  PRO L CA  1 
ATOM   5244 C C   . PRO D 2 50  ? 25.340  2.919   38.720  1.00 17.97  ? 50  PRO L C   1 
ATOM   5245 O O   . PRO D 2 50  ? 25.173  3.671   37.764  1.00 16.75  ? 50  PRO L O   1 
ATOM   5246 C CB  . PRO D 2 50  ? 23.120  1.985   39.224  1.00 16.56  ? 50  PRO L CB  1 
ATOM   5247 C CG  . PRO D 2 50  ? 21.857  2.846   39.354  1.00 17.34  ? 50  PRO L CG  1 
ATOM   5248 C CD  . PRO D 2 50  ? 22.310  4.289   39.400  1.00 16.43  ? 50  PRO L CD  1 
ATOM   5249 N N   . LYS D 2 51  ? 26.383  2.080   38.858  1.00 18.80  ? 51  LYS L N   1 
ATOM   5250 C CA  . LYS D 2 51  ? 27.421  1.987   37.846  1.00 22.93  ? 51  LYS L CA  1 
ATOM   5251 C C   . LYS D 2 51  ? 27.440  0.585   37.241  1.00 19.40  ? 51  LYS L C   1 
ATOM   5252 O O   . LYS D 2 51  ? 27.377  -0.403  37.964  1.00 19.76  ? 51  LYS L O   1 
ATOM   5253 C CB  . LYS D 2 51  ? 28.797  2.289   38.451  1.00 31.05  ? 51  LYS L CB  1 
ATOM   5254 C CG  . LYS D 2 51  ? 29.331  3.696   38.187  1.00 39.43  ? 51  LYS L CG  1 
ATOM   5255 C CD  . LYS D 2 51  ? 29.117  4.677   39.316  1.00 47.14  ? 51  LYS L CD  1 
ATOM   5256 C CE  . LYS D 2 51  ? 30.262  4.713   40.310  1.00 49.44  ? 51  LYS L CE  1 
ATOM   5257 N NZ  . LYS D 2 51  ? 31.257  5.755   39.976  1.00 49.87  ? 51  LYS L NZ  1 
ATOM   5258 N N   . LEU D 2 52  ? 27.625  0.519   35.926  1.00 16.57  ? 52  LEU L N   1 
ATOM   5259 C CA  . LEU D 2 52  ? 27.594  -0.729  35.193  1.00 17.37  ? 52  LEU L CA  1 
ATOM   5260 C C   . LEU D 2 52  ? 28.880  -1.504  35.426  1.00 16.41  ? 52  LEU L C   1 
ATOM   5261 O O   . LEU D 2 52  ? 29.966  -0.980  35.196  1.00 15.63  ? 52  LEU L O   1 
ATOM   5262 C CB  . LEU D 2 52  ? 27.419  -0.454  33.701  1.00 17.33  ? 52  LEU L CB  1 
ATOM   5263 C CG  . LEU D 2 52  ? 27.282  -1.692  32.817  1.00 16.37  ? 52  LEU L CG  1 
ATOM   5264 C CD1 . LEU D 2 52  ? 26.033  -2.490  33.153  1.00 16.24  ? 52  LEU L CD1 1 
ATOM   5265 C CD2 . LEU D 2 52  ? 27.247  -1.306  31.357  1.00 16.45  ? 52  LEU L CD2 1 
ATOM   5266 N N   . LEU D 2 53  ? 28.730  -2.752  35.866  1.00 15.99  ? 53  LEU L N   1 
ATOM   5267 C CA  . LEU D 2 53  ? 29.885  -3.607  36.116  1.00 16.70  ? 53  LEU L CA  1 
ATOM   5268 C C   . LEU D 2 53  ? 30.032  -4.621  35.002  1.00 16.17  ? 53  LEU L C   1 
ATOM   5269 O O   . LEU D 2 53  ? 31.134  -4.808  34.501  1.00 16.51  ? 53  LEU L O   1 
ATOM   5270 C CB  . LEU D 2 53  ? 29.692  -4.365  37.426  1.00 17.22  ? 53  LEU L CB  1 
ATOM   5271 C CG  . LEU D 2 53  ? 29.551  -3.505  38.666  1.00 19.22  ? 53  LEU L CG  1 
ATOM   5272 C CD1 . LEU D 2 53  ? 29.193  -4.358  39.870  1.00 21.15  ? 53  LEU L CD1 1 
ATOM   5273 C CD2 . LEU D 2 53  ? 30.836  -2.726  38.934  1.00 20.77  ? 53  LEU L CD2 1 
ATOM   5274 N N   . ILE D 2 54  ? 28.899  -5.278  34.682  1.00 17.16  ? 54  ILE L N   1 
ATOM   5275 C CA  . ILE D 2 54  ? 28.818  -6.479  33.860  1.00 15.77  ? 54  ILE L CA  1 
ATOM   5276 C C   . ILE D 2 54  ? 27.570  -6.359  32.996  1.00 14.79  ? 54  ILE L C   1 
ATOM   5277 O O   . ILE D 2 54  ? 26.517  -6.004  33.528  1.00 14.11  ? 54  ILE L O   1 
ATOM   5278 C CB  . ILE D 2 54  ? 28.682  -7.751  34.722  1.00 16.93  ? 54  ILE L CB  1 
ATOM   5279 C CG1 . ILE D 2 54  ? 29.771  -7.923  35.782  1.00 19.65  ? 54  ILE L CG1 1 
ATOM   5280 C CG2 . ILE D 2 54  ? 28.582  -8.974  33.837  1.00 18.46  ? 54  ILE L CG2 1 
ATOM   5281 C CD1 . ILE D 2 54  ? 31.160  -8.115  35.229  1.00 21.48  ? 54  ILE L CD1 1 
ATOM   5282 N N   . TYR D 2 55  ? 27.680  -6.736  31.714  1.00 14.47  ? 55  TYR L N   1 
ATOM   5283 C CA  . TYR D 2 55  ? 26.541  -6.784  30.815  1.00 16.40  ? 55  TYR L CA  1 
ATOM   5284 C C   . TYR D 2 55  ? 26.671  -8.013  29.914  1.00 17.52  ? 55  TYR L C   1 
ATOM   5285 O O   . TYR D 2 55  ? 27.686  -8.691  29.945  1.00 19.22  ? 55  TYR L O   1 
ATOM   5286 C CB  . TYR D 2 55  ? 26.369  -5.443  30.094  1.00 16.02  ? 55  TYR L CB  1 
ATOM   5287 C CG  . TYR D 2 55  ? 27.549  -5.038  29.247  1.00 16.91  ? 55  TYR L CG  1 
ATOM   5288 C CD1 . TYR D 2 55  ? 27.613  -5.407  27.921  1.00 17.20  ? 55  TYR L CD1 1 
ATOM   5289 C CD2 . TYR D 2 55  ? 28.581  -4.278  29.758  1.00 16.85  ? 55  TYR L CD2 1 
ATOM   5290 C CE1 . TYR D 2 55  ? 28.691  -5.071  27.125  1.00 18.91  ? 55  TYR L CE1 1 
ATOM   5291 C CE2 . TYR D 2 55  ? 29.664  -3.913  28.967  1.00 18.74  ? 55  TYR L CE2 1 
ATOM   5292 C CZ  . TYR D 2 55  ? 29.725  -4.320  27.649  1.00 20.21  ? 55  TYR L CZ  1 
ATOM   5293 O OH  . TYR D 2 55  ? 30.795  -4.018  26.839  1.00 25.31  ? 55  TYR L OH  1 
ATOM   5294 N N   . TRP D 2 56  ? 25.614  -8.337  29.150  1.00 18.66  ? 56  TRP L N   1 
ATOM   5295 C CA  . TRP D 2 56  ? 25.512  -9.616  28.454  1.00 18.68  ? 56  TRP L CA  1 
ATOM   5296 C C   . TRP D 2 56  ? 25.876  -10.781 29.386  1.00 19.15  ? 56  TRP L C   1 
ATOM   5297 O O   . TRP D 2 56  ? 26.423  -11.780 28.923  1.00 18.76  ? 56  TRP L O   1 
ATOM   5298 C CB  . TRP D 2 56  ? 26.364  -9.640  27.174  1.00 18.87  ? 56  TRP L CB  1 
ATOM   5299 C CG  . TRP D 2 56  ? 26.003  -8.612  26.143  1.00 17.55  ? 56  TRP L CG  1 
ATOM   5300 C CD1 . TRP D 2 56  ? 26.863  -7.741  25.544  1.00 18.01  ? 56  TRP L CD1 1 
ATOM   5301 C CD2 . TRP D 2 56  ? 24.702  -8.313  25.603  1.00 16.97  ? 56  TRP L CD2 1 
ATOM   5302 N NE1 . TRP D 2 56  ? 26.190  -6.944  24.659  1.00 18.90  ? 56  TRP L NE1 1 
ATOM   5303 C CE2 . TRP D 2 56  ? 24.853  -7.225  24.712  1.00 17.96  ? 56  TRP L CE2 1 
ATOM   5304 C CE3 . TRP D 2 56  ? 23.415  -8.816  25.806  1.00 17.28  ? 56  TRP L CE3 1 
ATOM   5305 C CZ2 . TRP D 2 56  ? 23.789  -6.690  23.976  1.00 17.32  ? 56  TRP L CZ2 1 
ATOM   5306 C CZ3 . TRP D 2 56  ? 22.365  -8.310  25.069  1.00 17.51  ? 56  TRP L CZ3 1 
ATOM   5307 C CH2 . TRP D 2 56  ? 22.544  -7.231  24.190  1.00 17.67  ? 56  TRP L CH2 1 
ATOM   5308 N N   . ALA D 2 57  ? 25.575  -10.620 30.691  1.00 17.37  ? 57  ALA L N   1 
ATOM   5309 C CA  . ALA D 2 57  ? 25.732  -11.607 31.765  1.00 18.52  ? 57  ALA L CA  1 
ATOM   5310 C C   . ALA D 2 57  ? 27.170  -11.775 32.237  1.00 18.49  ? 57  ALA L C   1 
ATOM   5311 O O   . ALA D 2 57  ? 27.324  -12.071 33.423  1.00 17.08  ? 57  ALA L O   1 
ATOM   5312 C CB  . ALA D 2 57  ? 25.136  -12.975 31.438  1.00 17.80  ? 57  ALA L CB  1 
ATOM   5313 N N   . SER D 2 58  ? 28.166  -11.666 31.321  1.00 18.73  ? 58  SER L N   1 
ATOM   5314 C CA  . SER D 2 58  ? 29.539  -12.033 31.623  1.00 21.15  ? 58  SER L CA  1 
ATOM   5315 C C   . SER D 2 58  ? 30.584  -11.055 31.081  1.00 20.08  ? 58  SER L C   1 
ATOM   5316 O O   . SER D 2 58  ? 31.758  -11.193 31.394  1.00 21.87  ? 58  SER L O   1 
ATOM   5317 C CB  . SER D 2 58  ? 29.837  -13.442 31.128  1.00 22.58  ? 58  SER L CB  1 
ATOM   5318 O OG  . SER D 2 58  ? 29.580  -13.530 29.741  1.00 27.46  ? 58  SER L OG  1 
ATOM   5319 N N   . THR D 2 59  ? 30.204  -10.064 30.281  1.00 19.78  ? 59  THR L N   1 
ATOM   5320 C CA  . THR D 2 59  ? 31.167  -9.113  29.757  1.00 19.27  ? 59  THR L CA  1 
ATOM   5321 C C   . THR D 2 59  ? 31.339  -7.957  30.759  1.00 21.52  ? 59  THR L C   1 
ATOM   5322 O O   . THR D 2 59  ? 30.383  -7.291  31.166  1.00 21.92  ? 59  THR L O   1 
ATOM   5323 C CB  . THR D 2 59  ? 30.707  -8.586  28.394  1.00 21.36  ? 59  THR L CB  1 
ATOM   5324 O OG1 . THR D 2 59  ? 30.453  -9.670  27.506  1.00 19.76  ? 59  THR L OG1 1 
ATOM   5325 C CG2 . THR D 2 59  ? 31.696  -7.609  27.783  1.00 20.83  ? 59  THR L CG2 1 
ATOM   5326 N N   . ARG D 2 60  ? 32.592  -7.681  31.091  1.00 22.36  ? 60  ARG L N   1 
ATOM   5327 C CA  . ARG D 2 60  ? 32.964  -6.643  32.031  1.00 25.29  ? 60  ARG L CA  1 
ATOM   5328 C C   . ARG D 2 60  ? 33.057  -5.304  31.326  1.00 24.21  ? 60  ARG L C   1 
ATOM   5329 O O   . ARG D 2 60  ? 33.646  -5.186  30.252  1.00 23.10  ? 60  ARG L O   1 
ATOM   5330 C CB  . ARG D 2 60  ? 34.301  -7.000  32.684  1.00 26.69  ? 60  ARG L CB  1 
ATOM   5331 C CG  . ARG D 2 60  ? 34.618  -6.176  33.918  1.00 27.20  ? 60  ARG L CG  1 
ATOM   5332 C CD  . ARG D 2 60  ? 35.498  -6.957  34.863  1.00 31.03  ? 60  ARG L CD  1 
ATOM   5333 N NE  . ARG D 2 60  ? 36.553  -7.609  34.133  1.00 31.59  ? 60  ARG L NE  1 
ATOM   5334 C CZ  . ARG D 2 60  ? 36.702  -8.931  34.021  1.00 35.03  ? 60  ARG L CZ  1 
ATOM   5335 N NH1 . ARG D 2 60  ? 36.122  -9.775  34.860  1.00 31.69  ? 60  ARG L NH1 1 
ATOM   5336 N NH2 . ARG D 2 60  ? 37.501  -9.402  33.081  1.00 32.89  ? 60  ARG L NH2 1 
ATOM   5337 N N   . GLU D 2 61  ? 32.437  -4.300  31.957  1.00 26.04  ? 61  GLU L N   1 
ATOM   5338 C CA  . GLU D 2 61  ? 32.481  -2.936  31.455  1.00 24.42  ? 61  GLU L CA  1 
ATOM   5339 C C   . GLU D 2 61  ? 33.919  -2.453  31.610  1.00 24.47  ? 61  GLU L C   1 
ATOM   5340 O O   . GLU D 2 61  ? 34.565  -2.772  32.612  1.00 24.77  ? 61  GLU L O   1 
ATOM   5341 C CB  . GLU D 2 61  ? 31.463  -2.092  32.247  1.00 24.54  ? 61  GLU L CB  1 
ATOM   5342 C CG  . GLU D 2 61  ? 31.614  -0.570  32.104  1.00 26.24  ? 61  GLU L CG  1 
ATOM   5343 C CD  . GLU D 2 61  ? 31.353  0.001   30.712  1.00 27.85  ? 61  GLU L CD  1 
ATOM   5344 O OE1 . GLU D 2 61  ? 30.998  -0.764  29.820  1.00 28.69  ? 61  GLU L OE1 1 
ATOM   5345 O OE2 . GLU D 2 61  ? 31.524  1.218   30.512  1.00 31.43  ? 61  GLU L OE2 1 
ATOM   5346 N N   . SER D 2 62  ? 34.373  -1.596  30.694  1.00 28.95  ? 62  SER L N   1 
ATOM   5347 C CA  . SER D 2 62  ? 35.732  -1.064  30.713  1.00 29.38  ? 62  SER L CA  1 
ATOM   5348 C C   . SER D 2 62  ? 36.052  -0.323  32.005  1.00 27.40  ? 62  SER L C   1 
ATOM   5349 O O   . SER D 2 62  ? 35.269  0.486   32.480  1.00 30.72  ? 62  SER L O   1 
ATOM   5350 C CB  . SER D 2 62  ? 35.960  -0.164  29.537  1.00 33.96  ? 62  SER L CB  1 
ATOM   5351 O OG  . SER D 2 62  ? 36.084  -0.955  28.367  1.00 38.74  ? 62  SER L OG  1 
ATOM   5352 N N   . GLY D 2 63  ? 37.226  -0.596  32.573  1.00 25.33  ? 63  GLY L N   1 
ATOM   5353 C CA  . GLY D 2 63  ? 37.659  0.107   33.762  1.00 24.25  ? 63  GLY L CA  1 
ATOM   5354 C C   . GLY D 2 63  ? 37.156  -0.528  35.054  1.00 24.82  ? 63  GLY L C   1 
ATOM   5355 O O   . GLY D 2 63  ? 37.669  -0.234  36.122  1.00 28.88  ? 63  GLY L O   1 
ATOM   5356 N N   . VAL D 2 64  ? 36.203  -1.455  34.962  1.00 23.44  ? 64  VAL L N   1 
ATOM   5357 C CA  . VAL D 2 64  ? 35.790  -2.206  36.122  1.00 21.79  ? 64  VAL L CA  1 
ATOM   5358 C C   . VAL D 2 64  ? 36.894  -3.213  36.452  1.00 23.02  ? 64  VAL L C   1 
ATOM   5359 O O   . VAL D 2 64  ? 37.393  -3.896  35.572  1.00 20.71  ? 64  VAL L O   1 
ATOM   5360 C CB  . VAL D 2 64  ? 34.431  -2.879  35.861  1.00 22.74  ? 64  VAL L CB  1 
ATOM   5361 C CG1 . VAL D 2 64  ? 34.032  -3.842  36.964  1.00 21.54  ? 64  VAL L CG1 1 
ATOM   5362 C CG2 . VAL D 2 64  ? 33.346  -1.829  35.639  1.00 22.44  ? 64  VAL L CG2 1 
ATOM   5363 N N   . PRO D 2 65  ? 37.294  -3.346  37.737  1.00 22.67  ? 65  PRO L N   1 
ATOM   5364 C CA  . PRO D 2 65  ? 38.313  -4.307  38.131  1.00 21.57  ? 65  PRO L CA  1 
ATOM   5365 C C   . PRO D 2 65  ? 37.901  -5.759  37.924  1.00 22.62  ? 65  PRO L C   1 
ATOM   5366 O O   . PRO D 2 65  ? 36.766  -6.181  38.221  1.00 19.30  ? 65  PRO L O   1 
ATOM   5367 C CB  . PRO D 2 65  ? 38.535  -4.051  39.622  1.00 21.58  ? 65  PRO L CB  1 
ATOM   5368 C CG  . PRO D 2 65  ? 37.962  -2.635  39.855  1.00 23.76  ? 65  PRO L CG  1 
ATOM   5369 C CD  . PRO D 2 65  ? 36.814  -2.549  38.877  1.00 22.91  ? 65  PRO L CD  1 
ATOM   5370 N N   . ASP D 2 66  ? 38.892  -6.508  37.445  1.00 21.44  ? 66  ASP L N   1 
ATOM   5371 C CA  . ASP D 2 66  ? 38.698  -7.866  36.996  1.00 22.53  ? 66  ASP L CA  1 
ATOM   5372 C C   . ASP D 2 66  ? 38.493  -8.804  38.173  1.00 19.61  ? 66  ASP L C   1 
ATOM   5373 O O   . ASP D 2 66  ? 38.301  -9.982  37.957  1.00 22.84  ? 66  ASP L O   1 
ATOM   5374 C CB  . ASP D 2 66  ? 39.818  -8.311  36.047  1.00 23.72  ? 66  ASP L CB  1 
ATOM   5375 C CG  . ASP D 2 66  ? 41.195  -8.501  36.667  1.00 24.63  ? 66  ASP L CG  1 
ATOM   5376 O OD1 . ASP D 2 66  ? 41.330  -8.309  37.907  1.00 25.15  ? 66  ASP L OD1 1 
ATOM   5377 O OD2 . ASP D 2 66  ? 42.130  -8.849  35.891  1.00 22.61  ? 66  ASP L OD2 1 
ATOM   5378 N N   . ARG D 2 67  ? 38.408  -8.294  39.399  1.00 20.93  ? 67  ARG L N   1 
ATOM   5379 C CA  . ARG D 2 67  ? 37.909  -9.127  40.482  1.00 21.82  ? 67  ARG L CA  1 
ATOM   5380 C C   . ARG D 2 67  ? 36.385  -9.290  40.409  1.00 22.35  ? 67  ARG L C   1 
ATOM   5381 O O   . ARG D 2 67  ? 35.842  -10.169 41.079  1.00 21.46  ? 67  ARG L O   1 
ATOM   5382 C CB  . ARG D 2 67  ? 38.405  -8.585  41.830  1.00 25.99  ? 67  ARG L CB  1 
ATOM   5383 C CG  . ARG D 2 67  ? 37.975  -7.169  42.174  1.00 29.60  ? 67  ARG L CG  1 
ATOM   5384 C CD  . ARG D 2 67  ? 38.342  -6.864  43.629  1.00 31.32  ? 67  ARG L CD  1 
ATOM   5385 N NE  . ARG D 2 67  ? 37.897  -5.538  44.031  1.00 29.01  ? 67  ARG L NE  1 
ATOM   5386 C CZ  . ARG D 2 67  ? 38.420  -4.399  43.584  1.00 26.78  ? 67  ARG L CZ  1 
ATOM   5387 N NH1 . ARG D 2 67  ? 39.565  -4.407  42.939  1.00 27.90  ? 67  ARG L NH1 1 
ATOM   5388 N NH2 . ARG D 2 67  ? 37.799  -3.250  43.794  1.00 26.96  ? 67  ARG L NH2 1 
ATOM   5389 N N   . PHE D 2 68  ? 35.686  -8.434  39.626  1.00 19.63  ? 68  PHE L N   1 
ATOM   5390 C CA  . PHE D 2 68  ? 34.262  -8.592  39.419  1.00 19.31  ? 68  PHE L CA  1 
ATOM   5391 C C   . PHE D 2 68  ? 34.061  -9.532  38.237  1.00 18.60  ? 68  PHE L C   1 
ATOM   5392 O O   . PHE D 2 68  ? 34.664  -9.334  37.199  1.00 17.88  ? 68  PHE L O   1 
ATOM   5393 C CB  . PHE D 2 68  ? 33.569  -7.254  39.136  1.00 17.79  ? 68  PHE L CB  1 
ATOM   5394 C CG  . PHE D 2 68  ? 33.540  -6.320  40.311  1.00 18.22  ? 68  PHE L CG  1 
ATOM   5395 C CD1 . PHE D 2 68  ? 32.535  -6.410  41.262  1.00 19.27  ? 68  PHE L CD1 1 
ATOM   5396 C CD2 . PHE D 2 68  ? 34.522  -5.363  40.475  1.00 19.29  ? 68  PHE L CD2 1 
ATOM   5397 C CE1 . PHE D 2 68  ? 32.507  -5.560  42.353  1.00 19.05  ? 68  PHE L CE1 1 
ATOM   5398 C CE2 . PHE D 2 68  ? 34.483  -4.500  41.553  1.00 21.53  ? 68  PHE L CE2 1 
ATOM   5399 C CZ  . PHE D 2 68  ? 33.476  -4.597  42.491  1.00 20.79  ? 68  PHE L CZ  1 
ATOM   5400 N N   . SER D 2 69  ? 33.184  -10.527 38.360  1.00 17.72  ? 69  SER L N   1 
ATOM   5401 C CA  . SER D 2 69  ? 32.792  -11.239 37.152  1.00 20.20  ? 69  SER L CA  1 
ATOM   5402 C C   . SER D 2 69  ? 31.373  -11.786 37.268  1.00 19.31  ? 69  SER L C   1 
ATOM   5403 O O   . SER D 2 69  ? 30.868  -12.100 38.356  1.00 22.04  ? 69  SER L O   1 
ATOM   5404 C CB  . SER D 2 69  ? 33.808  -12.314 36.825  1.00 22.01  ? 69  SER L CB  1 
ATOM   5405 O OG  . SER D 2 69  ? 33.899  -13.179 37.922  1.00 25.20  ? 69  SER L OG  1 
ATOM   5406 N N   . GLY D 2 70  ? 30.731  -11.939 36.115  1.00 19.09  ? 70  GLY L N   1 
ATOM   5407 C CA  . GLY D 2 70  ? 29.373  -12.464 36.091  1.00 19.20  ? 70  GLY L CA  1 
ATOM   5408 C C   . GLY D 2 70  ? 29.349  -13.789 35.350  1.00 19.49  ? 70  GLY L C   1 
ATOM   5409 O O   . GLY D 2 70  ? 30.187  -14.002 34.484  1.00 18.32  ? 70  GLY L O   1 
ATOM   5410 N N   . SER D 2 71  ? 28.384  -14.652 35.696  1.00 18.21  ? 71  SER L N   1 
ATOM   5411 C CA  . SER D 2 71  ? 28.183  -15.910 34.999  1.00 17.39  ? 71  SER L CA  1 
ATOM   5412 C C   . SER D 2 71  ? 26.726  -16.341 35.132  1.00 17.80  ? 71  SER L C   1 
ATOM   5413 O O   . SER D 2 71  ? 25.904  -15.647 35.756  1.00 20.73  ? 71  SER L O   1 
ATOM   5414 C CB  . SER D 2 71  ? 29.118  -16.955 35.531  1.00 19.42  ? 71  SER L CB  1 
ATOM   5415 O OG  . SER D 2 71  ? 29.036  -17.014 36.957  1.00 22.61  ? 71  SER L OG  1 
ATOM   5416 N N   . GLY D 2 72  ? 26.408  -17.460 34.482  1.00 16.44  ? 72  GLY L N   1 
ATOM   5417 C CA  . GLY D 2 72  ? 25.059  -18.004 34.448  1.00 17.58  ? 72  GLY L CA  1 
ATOM   5418 C C   . GLY D 2 72  ? 24.423  -17.803 33.076  1.00 17.91  ? 72  GLY L C   1 
ATOM   5419 O O   . GLY D 2 72  ? 25.002  -17.178 32.206  1.00 18.66  ? 72  GLY L O   1 
ATOM   5420 N N   . SER D 2 73  ? 23.218  -18.318 32.895  1.00 19.03  ? 73  SER L N   1 
ATOM   5421 C CA  . SER D 2 73  ? 22.562  -18.264 31.604  1.00 20.11  ? 73  SER L CA  1 
ATOM   5422 C C   . SER D 2 73  ? 21.097  -18.606 31.799  1.00 18.83  ? 73  SER L C   1 
ATOM   5423 O O   . SER D 2 73  ? 20.744  -19.270 32.764  1.00 19.42  ? 73  SER L O   1 
ATOM   5424 C CB  . SER D 2 73  ? 23.235  -19.225 30.639  1.00 23.01  ? 73  SER L CB  1 
ATOM   5425 O OG  . SER D 2 73  ? 22.727  -19.053 29.320  1.00 24.36  ? 73  SER L OG  1 
ATOM   5426 N N   . GLY D 2 74  ? 20.240  -18.102 30.910  1.00 18.67  ? 74  GLY L N   1 
ATOM   5427 C CA  . GLY D 2 74  ? 18.821  -18.363 30.995  1.00 17.08  ? 74  GLY L CA  1 
ATOM   5428 C C   . GLY D 2 74  ? 18.150  -17.602 32.133  1.00 20.05  ? 74  GLY L C   1 
ATOM   5429 O O   . GLY D 2 74  ? 17.706  -16.464 31.946  1.00 18.35  ? 74  GLY L O   1 
ATOM   5430 N N   . THR D 2 75  ? 17.978  -18.289 33.271  1.00 19.36  ? 75  THR L N   1 
ATOM   5431 C CA  . THR D 2 75  ? 17.237  -17.764 34.402  1.00 21.65  ? 75  THR L CA  1 
ATOM   5432 C C   . THR D 2 75  ? 18.094  -17.578 35.657  1.00 20.67  ? 75  THR L C   1 
ATOM   5433 O O   . THR D 2 75  ? 17.599  -17.020 36.636  1.00 24.40  ? 75  THR L O   1 
ATOM   5434 C CB  . THR D 2 75  ? 16.082  -18.702 34.762  1.00 21.67  ? 75  THR L CB  1 
ATOM   5435 O OG1 . THR D 2 75  ? 16.632  -19.981 35.095  1.00 20.41  ? 75  THR L OG1 1 
ATOM   5436 C CG2 . THR D 2 75  ? 15.101  -18.862 33.623  1.00 24.05  ? 75  THR L CG2 1 
ATOM   5437 N N   . ASP D 2 76  ? 19.335  -18.081 35.672  1.00 18.74  ? 76  ASP L N   1 
ATOM   5438 C CA  . ASP D 2 76  ? 20.114  -18.136 36.906  1.00 18.96  ? 76  ASP L CA  1 
ATOM   5439 C C   . ASP D 2 76  ? 21.448  -17.443 36.670  1.00 19.36  ? 76  ASP L C   1 
ATOM   5440 O O   . ASP D 2 76  ? 22.186  -17.839 35.764  1.00 21.96  ? 76  ASP L O   1 
ATOM   5441 C CB  . ASP D 2 76  ? 20.317  -19.581 37.385  1.00 20.32  ? 76  ASP L CB  1 
ATOM   5442 C CG  . ASP D 2 76  ? 19.004  -20.279 37.714  1.00 22.00  ? 76  ASP L CG  1 
ATOM   5443 O OD1 . ASP D 2 76  ? 18.516  -20.155 38.838  1.00 27.27  ? 76  ASP L OD1 1 
ATOM   5444 O OD2 . ASP D 2 76  ? 18.440  -20.883 36.826  1.00 29.32  ? 76  ASP L OD2 1 
ATOM   5445 N N   . PHE D 2 77  ? 21.743  -16.408 37.473  1.00 18.44  ? 77  PHE L N   1 
ATOM   5446 C CA  . PHE D 2 77  ? 22.965  -15.639 37.279  1.00 17.97  ? 77  PHE L CA  1 
ATOM   5447 C C   . PHE D 2 77  ? 23.670  -15.399 38.604  1.00 17.47  ? 77  PHE L C   1 
ATOM   5448 O O   . PHE D 2 77  ? 23.032  -15.366 39.656  1.00 18.50  ? 77  PHE L O   1 
ATOM   5449 C CB  . PHE D 2 77  ? 22.657  -14.303 36.593  1.00 16.51  ? 77  PHE L CB  1 
ATOM   5450 C CG  . PHE D 2 77  ? 22.013  -14.495 35.247  1.00 17.31  ? 77  PHE L CG  1 
ATOM   5451 C CD1 . PHE D 2 77  ? 20.633  -14.645 35.135  1.00 17.92  ? 77  PHE L CD1 1 
ATOM   5452 C CD2 . PHE D 2 77  ? 22.783  -14.637 34.117  1.00 15.72  ? 77  PHE L CD2 1 
ATOM   5453 C CE1 . PHE D 2 77  ? 20.033  -14.817 33.897  1.00 17.00  ? 77  PHE L CE1 1 
ATOM   5454 C CE2 . PHE D 2 77  ? 22.184  -14.828 32.883  1.00 17.25  ? 77  PHE L CE2 1 
ATOM   5455 C CZ  . PHE D 2 77  ? 20.816  -14.929 32.774  1.00 18.05  ? 77  PHE L CZ  1 
ATOM   5456 N N   . THR D 2 78  ? 24.972  -15.128 38.503  1.00 16.92  ? 78  THR L N   1 
ATOM   5457 C CA  . THR D 2 78  ? 25.804  -14.934 39.678  1.00 18.37  ? 78  THR L CA  1 
ATOM   5458 C C   . THR D 2 78  ? 26.762  -13.774 39.421  1.00 16.11  ? 78  THR L C   1 
ATOM   5459 O O   . THR D 2 78  ? 27.367  -13.711 38.357  1.00 15.30  ? 78  THR L O   1 
ATOM   5460 C CB  . THR D 2 78  ? 26.540  -16.235 40.051  1.00 20.05  ? 78  THR L CB  1 
ATOM   5461 O OG1 . THR D 2 78  ? 25.544  -17.147 40.518  1.00 21.94  ? 78  THR L OG1 1 
ATOM   5462 C CG2 . THR D 2 78  ? 27.545  -16.074 41.172  1.00 22.23  ? 78  THR L CG2 1 
ATOM   5463 N N   . LEU D 2 79  ? 26.871  -12.860 40.390  1.00 15.60  ? 79  LEU L N   1 
ATOM   5464 C CA  . LEU D 2 79  ? 27.960  -11.883 40.400  1.00 15.04  ? 79  LEU L CA  1 
ATOM   5465 C C   . LEU D 2 79  ? 28.973  -12.340 41.445  1.00 15.57  ? 79  LEU L C   1 
ATOM   5466 O O   . LEU D 2 79  ? 28.617  -12.631 42.588  1.00 17.18  ? 79  LEU L O   1 
ATOM   5467 C CB  . LEU D 2 79  ? 27.441  -10.480 40.740  1.00 14.85  ? 79  LEU L CB  1 
ATOM   5468 C CG  . LEU D 2 79  ? 28.515  -9.390  40.849  1.00 16.19  ? 79  LEU L CG  1 
ATOM   5469 C CD1 . LEU D 2 79  ? 29.115  -9.032  39.503  1.00 16.28  ? 79  LEU L CD1 1 
ATOM   5470 C CD2 . LEU D 2 79  ? 27.939  -8.133  41.468  1.00 18.03  ? 79  LEU L CD2 1 
ATOM   5471 N N   . THR D 2 80  ? 30.229  -12.424 41.057  1.00 16.58  ? 80  THR L N   1 
ATOM   5472 C CA  . THR D 2 80  ? 31.256  -12.885 41.988  1.00 18.84  ? 80  THR L CA  1 
ATOM   5473 C C   . THR D 2 80  ? 32.314  -11.801 42.161  1.00 18.81  ? 80  THR L C   1 
ATOM   5474 O O   . THR D 2 80  ? 32.827  -11.274 41.172  1.00 16.25  ? 80  THR L O   1 
ATOM   5475 C CB  . THR D 2 80  ? 31.923  -14.172 41.478  1.00 18.74  ? 80  THR L CB  1 
ATOM   5476 O OG1 . THR D 2 80  ? 30.891  -15.157 41.420  1.00 21.19  ? 80  THR L OG1 1 
ATOM   5477 C CG2 . THR D 2 80  ? 33.060  -14.659 42.348  1.00 19.01  ? 80  THR L CG2 1 
ATOM   5478 N N   . ILE D 2 81  ? 32.632  -11.493 43.419  1.00 20.80  ? 81  ILE L N   1 
ATOM   5479 C CA  . ILE D 2 81  ? 33.798  -10.685 43.740  1.00 23.28  ? 81  ILE L CA  1 
ATOM   5480 C C   . ILE D 2 81  ? 34.863  -11.615 44.319  1.00 23.60  ? 81  ILE L C   1 
ATOM   5481 O O   . ILE D 2 81  ? 34.664  -12.153 45.399  1.00 24.52  ? 81  ILE L O   1 
ATOM   5482 C CB  . ILE D 2 81  ? 33.429  -9.556  44.717  1.00 25.78  ? 81  ILE L CB  1 
ATOM   5483 C CG1 . ILE D 2 81  ? 32.162  -8.810  44.274  1.00 28.41  ? 81  ILE L CG1 1 
ATOM   5484 C CG2 . ILE D 2 81  ? 34.615  -8.616  44.851  1.00 27.89  ? 81  ILE L CG2 1 
ATOM   5485 C CD1 . ILE D 2 81  ? 31.528  -7.915  45.323  1.00 29.09  ? 81  ILE L CD1 1 
ATOM   5486 N N   . SER D 2 82  ? 35.959  -11.821 43.584  1.00 24.27  ? 82  SER L N   1 
ATOM   5487 C CA  . SER D 2 82  ? 36.919  -12.882 43.886  1.00 27.73  ? 82  SER L CA  1 
ATOM   5488 C C   . SER D 2 82  ? 37.625  -12.577 45.196  1.00 30.14  ? 82  SER L C   1 
ATOM   5489 O O   . SER D 2 82  ? 37.811  -13.494 45.996  1.00 38.81  ? 82  SER L O   1 
ATOM   5490 C CB  . SER D 2 82  ? 37.932  -13.111 42.787  1.00 27.61  ? 82  SER L CB  1 
ATOM   5491 O OG  . SER D 2 82  ? 38.647  -11.914 42.500  1.00 30.67  ? 82  SER L OG  1 
ATOM   5492 N N   . SER D 2 83  ? 37.977  -11.301 45.418  1.00 28.34  ? 83  SER L N   1 
ATOM   5493 C CA  . SER D 2 83  ? 38.701  -10.918 46.624  1.00 29.21  ? 83  SER L CA  1 
ATOM   5494 C C   . SER D 2 83  ? 38.235  -9.556  47.135  1.00 26.17  ? 83  SER L C   1 
ATOM   5495 O O   . SER D 2 83  ? 38.671  -8.540  46.624  1.00 25.77  ? 83  SER L O   1 
ATOM   5496 C CB  . SER D 2 83  ? 40.185  -10.930 46.372  1.00 28.60  ? 83  SER L CB  1 
ATOM   5497 O OG  . SER D 2 83  ? 40.859  -10.832 47.606  1.00 33.62  ? 83  SER L OG  1 
ATOM   5498 N N   . LEU D 2 84  ? 37.350  -9.553  48.145  1.00 26.01  ? 84  LEU L N   1 
ATOM   5499 C CA  . LEU D 2 84  ? 36.606  -8.361  48.536  1.00 25.30  ? 84  LEU L CA  1 
ATOM   5500 C C   . LEU D 2 84  ? 37.542  -7.273  49.043  1.00 26.35  ? 84  LEU L C   1 
ATOM   5501 O O   . LEU D 2 84  ? 38.264  -7.502  50.005  1.00 28.78  ? 84  LEU L O   1 
ATOM   5502 C CB  . LEU D 2 84  ? 35.608  -8.695  49.647  1.00 25.78  ? 84  LEU L CB  1 
ATOM   5503 C CG  . LEU D 2 84  ? 34.614  -7.571  49.931  1.00 26.12  ? 84  LEU L CG  1 
ATOM   5504 C CD1 . LEU D 2 84  ? 33.461  -7.643  48.952  1.00 27.41  ? 84  LEU L CD1 1 
ATOM   5505 C CD2 . LEU D 2 84  ? 34.106  -7.618  51.352  1.00 27.14  ? 84  LEU L CD2 1 
ATOM   5506 N N   . GLN D 2 85  ? 37.516  -6.097  48.405  1.00 28.86  ? 85  GLN L N   1 
ATOM   5507 C CA  . GLN D 2 85  ? 38.212  -4.919  48.924  1.00 29.33  ? 85  GLN L CA  1 
ATOM   5508 C C   . GLN D 2 85  ? 37.206  -3.972  49.577  1.00 29.00  ? 85  GLN L C   1 
ATOM   5509 O O   . GLN D 2 85  ? 36.000  -4.083  49.345  1.00 29.25  ? 85  GLN L O   1 
ATOM   5510 C CB  . GLN D 2 85  ? 38.984  -4.205  47.818  1.00 29.92  ? 85  GLN L CB  1 
ATOM   5511 C CG  . GLN D 2 85  ? 40.104  -5.054  47.244  1.00 34.48  ? 85  GLN L CG  1 
ATOM   5512 C CD  . GLN D 2 85  ? 41.014  -4.284  46.314  1.00 38.50  ? 85  GLN L CD  1 
ATOM   5513 O OE1 . GLN D 2 85  ? 41.034  -3.055  46.261  1.00 39.48  ? 85  GLN L OE1 1 
ATOM   5514 N NE2 . GLN D 2 85  ? 41.807  -5.022  45.566  1.00 44.19  ? 85  GLN L NE2 1 
ATOM   5515 N N   . ALA D 2 86  ? 37.721  -3.039  50.393  1.00 27.36  ? 86  ALA L N   1 
ATOM   5516 C CA  . ALA D 2 86  ? 36.895  -2.172  51.227  1.00 27.24  ? 86  ALA L CA  1 
ATOM   5517 C C   . ALA D 2 86  ? 35.949  -1.319  50.372  1.00 24.01  ? 86  ALA L C   1 
ATOM   5518 O O   . ALA D 2 86  ? 34.781  -1.165  50.713  1.00 21.68  ? 86  ALA L O   1 
ATOM   5519 C CB  . ALA D 2 86  ? 37.763  -1.310  52.128  1.00 27.22  ? 86  ALA L CB  1 
ATOM   5520 N N   . GLU D 2 87  ? 36.441  -0.863  49.218  1.00 24.49  ? 87  GLU L N   1 
ATOM   5521 C CA  . GLU D 2 87  ? 35.697  0.001   48.327  1.00 27.70  ? 87  GLU L CA  1 
ATOM   5522 C C   . GLU D 2 87  ? 34.535  -0.750  47.671  1.00 23.87  ? 87  GLU L C   1 
ATOM   5523 O O   . GLU D 2 87  ? 33.788  -0.120  46.957  1.00 20.09  ? 87  GLU L O   1 
ATOM   5524 C CB  . GLU D 2 87  ? 36.544  0.537   47.171  1.00 30.29  ? 87  GLU L CB  1 
ATOM   5525 C CG  . GLU D 2 87  ? 37.941  0.950   47.563  1.00 39.57  ? 87  GLU L CG  1 
ATOM   5526 C CD  . GLU D 2 87  ? 38.926  -0.212  47.624  1.00 41.46  ? 87  GLU L CD  1 
ATOM   5527 O OE1 . GLU D 2 87  ? 39.305  -0.582  48.747  1.00 36.62  ? 87  GLU L OE1 1 
ATOM   5528 O OE2 . GLU D 2 87  ? 39.299  -0.744  46.544  1.00 41.18  ? 87  GLU L OE2 1 
ATOM   5529 N N   . ASP D 2 88  ? 34.443  -2.073  47.832  1.00 21.55  ? 88  ASP L N   1 
ATOM   5530 C CA  . ASP D 2 88  ? 33.371  -2.852  47.229  1.00 23.25  ? 88  ASP L CA  1 
ATOM   5531 C C   . ASP D 2 88  ? 32.096  -2.876  48.080  1.00 21.00  ? 88  ASP L C   1 
ATOM   5532 O O   . ASP D 2 88  ? 31.082  -3.408  47.656  1.00 22.43  ? 88  ASP L O   1 
ATOM   5533 C CB  . ASP D 2 88  ? 33.842  -4.285  46.980  1.00 24.90  ? 88  ASP L CB  1 
ATOM   5534 C CG  . ASP D 2 88  ? 35.005  -4.369  46.013  1.00 25.82  ? 88  ASP L CG  1 
ATOM   5535 O OD1 . ASP D 2 88  ? 35.131  -3.432  45.212  1.00 25.08  ? 88  ASP L OD1 1 
ATOM   5536 O OD2 . ASP D 2 88  ? 35.774  -5.376  46.079  1.00 23.10  ? 88  ASP L OD2 1 
ATOM   5537 N N   . VAL D 2 89  ? 32.140  -2.351  49.298  1.00 22.74  ? 89  VAL L N   1 
ATOM   5538 C CA  . VAL D 2 89  ? 30.948  -2.214  50.112  1.00 23.30  ? 89  VAL L CA  1 
ATOM   5539 C C   . VAL D 2 89  ? 30.007  -1.259  49.375  1.00 20.58  ? 89  VAL L C   1 
ATOM   5540 O O   . VAL D 2 89  ? 30.417  -0.155  49.089  1.00 21.78  ? 89  VAL L O   1 
ATOM   5541 C CB  . VAL D 2 89  ? 31.316  -1.722  51.524  1.00 27.82  ? 89  VAL L CB  1 
ATOM   5542 C CG1 . VAL D 2 89  ? 30.083  -1.336  52.343  1.00 30.25  ? 89  VAL L CG1 1 
ATOM   5543 C CG2 . VAL D 2 89  ? 32.141  -2.763  52.269  1.00 27.69  ? 89  VAL L CG2 1 
ATOM   5544 N N   . ALA D 2 90  ? 28.783  -1.725  49.060  1.00 18.18  ? 90  ALA L N   1 
ATOM   5545 C CA  . ALA D 2 90  ? 27.825  -1.065  48.195  1.00 16.41  ? 90  ALA L CA  1 
ATOM   5546 C C   . ALA D 2 90  ? 26.584  -1.954  48.113  1.00 16.96  ? 90  ALA L C   1 
ATOM   5547 O O   . ALA D 2 90  ? 26.602  -3.062  48.661  1.00 17.51  ? 90  ALA L O   1 
ATOM   5548 C CB  . ALA D 2 90  ? 28.414  -0.871  46.817  1.00 17.01  ? 90  ALA L CB  1 
ATOM   5549 N N   . VAL D 2 91  ? 25.538  -1.454  47.423  1.00 14.79  ? 91  VAL L N   1 
ATOM   5550 C CA  . VAL D 2 91  ? 24.382  -2.235  47.024  1.00 15.55  ? 91  VAL L CA  1 
ATOM   5551 C C   . VAL D 2 91  ? 24.577  -2.658  45.568  1.00 14.92  ? 91  VAL L C   1 
ATOM   5552 O O   . VAL D 2 91  ? 25.013  -1.870  44.740  1.00 12.69  ? 91  VAL L O   1 
ATOM   5553 C CB  . VAL D 2 91  ? 23.050  -1.481  47.182  1.00 16.49  ? 91  VAL L CB  1 
ATOM   5554 C CG1 . VAL D 2 91  ? 21.890  -2.415  46.881  1.00 17.04  ? 91  VAL L CG1 1 
ATOM   5555 C CG2 . VAL D 2 91  ? 22.881  -0.845  48.568  1.00 16.23  ? 91  VAL L CG2 1 
ATOM   5556 N N   . TYR D 2 92  ? 24.229  -3.914  45.276  1.00 14.39  ? 92  TYR L N   1 
ATOM   5557 C CA  . TYR D 2 92  ? 24.358  -4.503  43.951  1.00 14.11  ? 92  TYR L CA  1 
ATOM   5558 C C   . TYR D 2 92  ? 22.979  -4.866  43.426  1.00 13.57  ? 92  TYR L C   1 
ATOM   5559 O O   . TYR D 2 92  ? 22.185  -5.449  44.161  1.00 13.35  ? 92  TYR L O   1 
ATOM   5560 C CB  . TYR D 2 92  ? 25.259  -5.750  43.990  1.00 14.43  ? 92  TYR L CB  1 
ATOM   5561 C CG  . TYR D 2 92  ? 26.697  -5.390  44.264  1.00 14.48  ? 92  TYR L CG  1 
ATOM   5562 C CD1 . TYR D 2 92  ? 27.140  -5.243  45.567  1.00 15.45  ? 92  TYR L CD1 1 
ATOM   5563 C CD2 . TYR D 2 92  ? 27.561  -5.071  43.238  1.00 13.48  ? 92  TYR L CD2 1 
ATOM   5564 C CE1 . TYR D 2 92  ? 28.439  -4.862  45.846  1.00 14.26  ? 92  TYR L CE1 1 
ATOM   5565 C CE2 . TYR D 2 92  ? 28.842  -4.630  43.500  1.00 14.55  ? 92  TYR L CE2 1 
ATOM   5566 C CZ  . TYR D 2 92  ? 29.271  -4.520  44.808  1.00 13.71  ? 92  TYR L CZ  1 
ATOM   5567 O OH  . TYR D 2 92  ? 30.504  -4.089  45.106  1.00 14.89  ? 92  TYR L OH  1 
ATOM   5568 N N   . TYR D 2 93  ? 22.749  -4.605  42.130  1.00 13.93  ? 93  TYR L N   1 
ATOM   5569 C CA  . TYR D 2 93  ? 21.473  -4.860  41.506  1.00 13.90  ? 93  TYR L CA  1 
ATOM   5570 C C   . TYR D 2 93  ? 21.702  -5.590  40.206  1.00 15.11  ? 93  TYR L C   1 
ATOM   5571 O O   . TYR D 2 93  ? 22.591  -5.183  39.454  1.00 14.39  ? 93  TYR L O   1 
ATOM   5572 C CB  . TYR D 2 93  ? 20.742  -3.564  41.133  1.00 14.63  ? 93  TYR L CB  1 
ATOM   5573 C CG  . TYR D 2 93  ? 20.333  -2.722  42.310  1.00 14.91  ? 93  TYR L CG  1 
ATOM   5574 C CD1 . TYR D 2 93  ? 19.109  -2.896  42.929  1.00 16.36  ? 93  TYR L CD1 1 
ATOM   5575 C CD2 . TYR D 2 93  ? 21.157  -1.725  42.786  1.00 14.70  ? 93  TYR L CD2 1 
ATOM   5576 C CE1 . TYR D 2 93  ? 18.708  -2.102  44.002  1.00 16.33  ? 93  TYR L CE1 1 
ATOM   5577 C CE2 . TYR D 2 93  ? 20.769  -0.910  43.833  1.00 14.78  ? 93  TYR L CE2 1 
ATOM   5578 C CZ  . TYR D 2 93  ? 19.544  -1.093  44.445  1.00 16.51  ? 93  TYR L CZ  1 
ATOM   5579 O OH  . TYR D 2 93  ? 19.189  -0.325  45.535  1.00 19.32  ? 93  TYR L OH  1 
ATOM   5580 N N   . CYS D 2 94  ? 20.842  -6.596  39.947  1.00 14.66  ? 94  CYS L N   1 
ATOM   5581 C CA  . CYS D 2 94  ? 20.727  -7.141  38.622  1.00 16.12  ? 94  CYS L CA  1 
ATOM   5582 C C   . CYS D 2 94  ? 19.590  -6.437  37.895  1.00 15.00  ? 94  CYS L C   1 
ATOM   5583 O O   . CYS D 2 94  ? 18.656  -5.904  38.513  1.00 13.10  ? 94  CYS L O   1 
ATOM   5584 C CB  . CYS D 2 94  ? 20.541  -8.660  38.603  1.00 20.19  ? 94  CYS L CB  1 
ATOM   5585 S SG  . CYS D 2 94  ? 19.077  -9.256  39.484  1.00 26.57  ? 94  CYS L SG  1 
ATOM   5586 N N   . LEU D 2 95  ? 19.718  -6.487  36.558  1.00 14.56  ? 95  LEU L N   1 
ATOM   5587 C CA  . LEU D 2 95  ? 18.781  -5.913  35.604  1.00 15.32  ? 95  LEU L CA  1 
ATOM   5588 C C   . LEU D 2 95  ? 18.641  -6.880  34.431  1.00 15.47  ? 95  LEU L C   1 
ATOM   5589 O O   . LEU D 2 95  ? 19.637  -7.243  33.826  1.00 17.43  ? 95  LEU L O   1 
ATOM   5590 C CB  . LEU D 2 95  ? 19.327  -4.574  35.086  1.00 13.99  ? 95  LEU L CB  1 
ATOM   5591 C CG  . LEU D 2 95  ? 18.579  -3.978  33.896  1.00 13.46  ? 95  LEU L CG  1 
ATOM   5592 C CD1 . LEU D 2 95  ? 17.202  -3.481  34.298  1.00 12.80  ? 95  LEU L CD1 1 
ATOM   5593 C CD2 . LEU D 2 95  ? 19.355  -2.843  33.252  1.00 13.31  ? 95  LEU L CD2 1 
ATOM   5594 N N   . GLN D 2 96  ? 17.407  -7.223  34.078  1.00 14.88  ? 96  GLN L N   1 
ATOM   5595 C CA  . GLN D 2 96  ? 17.103  -7.719  32.749  1.00 14.75  ? 96  GLN L CA  1 
ATOM   5596 C C   . GLN D 2 96  ? 16.557  -6.578  31.879  1.00 14.03  ? 96  GLN L C   1 
ATOM   5597 O O   . GLN D 2 96  ? 15.716  -5.761  32.302  1.00 16.09  ? 96  GLN L O   1 
ATOM   5598 C CB  . GLN D 2 96  ? 16.115  -8.890  32.817  1.00 14.59  ? 96  GLN L CB  1 
ATOM   5599 C CG  . GLN D 2 96  ? 14.672  -8.466  33.001  1.00 15.01  ? 96  GLN L CG  1 
ATOM   5600 C CD  . GLN D 2 96  ? 13.980  -7.964  31.754  1.00 15.55  ? 96  GLN L CD  1 
ATOM   5601 O OE1 . GLN D 2 96  ? 14.328  -8.281  30.615  1.00 16.01  ? 96  GLN L OE1 1 
ATOM   5602 N NE2 . GLN D 2 96  ? 12.905  -7.245  31.975  1.00 16.15  ? 96  GLN L NE2 1 
ATOM   5603 N N   . TYR D 2 97  ? 16.973  -6.635  30.619  1.00 12.91  ? 97  TYR L N   1 
ATOM   5604 C CA  . TYR D 2 97  ? 16.631  -5.663  29.598  1.00 13.66  ? 97  TYR L CA  1 
ATOM   5605 C C   . TYR D 2 97  ? 16.244  -6.386  28.318  1.00 13.61  ? 97  TYR L C   1 
ATOM   5606 O O   . TYR D 2 97  ? 16.426  -5.826  27.256  1.00 14.79  ? 97  TYR L O   1 
ATOM   5607 C CB  . TYR D 2 97  ? 17.807  -4.689  29.350  1.00 12.29  ? 97  TYR L CB  1 
ATOM   5608 C CG  . TYR D 2 97  ? 19.180  -5.312  29.144  1.00 12.10  ? 97  TYR L CG  1 
ATOM   5609 C CD1 . TYR D 2 97  ? 20.025  -5.608  30.184  1.00 11.82  ? 97  TYR L CD1 1 
ATOM   5610 C CD2 . TYR D 2 97  ? 19.652  -5.580  27.866  1.00 12.50  ? 97  TYR L CD2 1 
ATOM   5611 C CE1 . TYR D 2 97  ? 21.287  -6.155  29.961  1.00 12.13  ? 97  TYR L CE1 1 
ATOM   5612 C CE2 . TYR D 2 97  ? 20.887  -6.147  27.624  1.00 11.72  ? 97  TYR L CE2 1 
ATOM   5613 C CZ  . TYR D 2 97  ? 21.713  -6.450  28.682  1.00 11.91  ? 97  TYR L CZ  1 
ATOM   5614 O OH  . TYR D 2 97  ? 22.944  -6.984  28.364  1.00 12.92  ? 97  TYR L OH  1 
ATOM   5615 N N   . LEU D 2 98  ? 15.770  -7.639  28.402  1.00 14.60  ? 98  LEU L N   1 
ATOM   5616 C CA  . LEU D 2 98  ? 15.248  -8.320  27.230  1.00 15.33  ? 98  LEU L CA  1 
ATOM   5617 C C   . LEU D 2 98  ? 13.914  -7.695  26.838  1.00 15.72  ? 98  LEU L C   1 
ATOM   5618 O O   . LEU D 2 98  ? 13.624  -7.445  25.677  1.00 15.08  ? 98  LEU L O   1 
ATOM   5619 C CB  . LEU D 2 98  ? 14.982  -9.800  27.506  1.00 15.45  ? 98  LEU L CB  1 
ATOM   5620 C CG  . LEU D 2 98  ? 15.279  -10.776 26.365  1.00 16.62  ? 98  LEU L CG  1 
ATOM   5621 C CD1 . LEU D 2 98  ? 14.378  -12.006 26.417  1.00 16.54  ? 98  LEU L CD1 1 
ATOM   5622 C CD2 . LEU D 2 98  ? 15.278  -10.155 24.992  1.00 15.87  ? 98  LEU L CD2 1 
ATOM   5623 N N   . SER D 2 99  ? 13.083  -7.531  27.841  1.00 15.95  ? 99  SER L N   1 
ATOM   5624 C CA  . SER D 2 99  ? 11.698  -7.210  27.618  1.00 20.58  ? 99  SER L CA  1 
ATOM   5625 C C   . SER D 2 99  ? 11.345  -6.135  28.627  1.00 18.06  ? 99  SER L C   1 
ATOM   5626 O O   . SER D 2 99  ? 11.131  -6.459  29.781  1.00 16.67  ? 99  SER L O   1 
ATOM   5627 C CB  . SER D 2 99  ? 10.854  -8.456  27.797  1.00 23.91  ? 99  SER L CB  1 
ATOM   5628 O OG  . SER D 2 99  ? 9.513   -8.154  27.484  1.00 28.48  ? 99  SER L OG  1 
ATOM   5629 N N   . SER D 2 100 ? 11.436  -4.866  28.215  1.00 19.39  ? 100 SER L N   1 
ATOM   5630 C CA  . SER D 2 100 ? 11.430  -3.751  29.157  1.00 19.85  ? 100 SER L CA  1 
ATOM   5631 C C   . SER D 2 100 ? 12.686  -3.847  30.030  1.00 17.76  ? 100 SER L C   1 
ATOM   5632 O O   . SER D 2 100 ? 13.635  -4.529  29.652  1.00 17.53  ? 100 SER L O   1 
ATOM   5633 C CB  . SER D 2 100 ? 10.112  -3.717  29.948  1.00 20.26  ? 100 SER L CB  1 
ATOM   5634 O OG  . SER D 2 100 ? 9.036   -3.358  29.076  1.00 25.37  ? 100 SER L OG  1 
ATOM   5635 N N   . TRP D 2 101 ? 12.679  -3.168  31.190  1.00 16.79  ? 101 TRP L N   1 
ATOM   5636 C CA  . TRP D 2 101 ? 13.678  -3.304  32.231  1.00 15.75  ? 101 TRP L CA  1 
ATOM   5637 C C   . TRP D 2 101 ? 12.990  -3.816  33.501  1.00 15.34  ? 101 TRP L C   1 
ATOM   5638 O O   . TRP D 2 101 ? 11.931  -3.310  33.892  1.00 14.78  ? 101 TRP L O   1 
ATOM   5639 C CB  . TRP D 2 101 ? 14.368  -1.958  32.549  1.00 14.46  ? 101 TRP L CB  1 
ATOM   5640 C CG  . TRP D 2 101 ? 15.435  -1.475  31.616  1.00 13.62  ? 101 TRP L CG  1 
ATOM   5641 C CD1 . TRP D 2 101 ? 15.735  -1.935  30.370  1.00 13.91  ? 101 TRP L CD1 1 
ATOM   5642 C CD2 . TRP D 2 101 ? 16.402  -0.439  31.893  1.00 12.34  ? 101 TRP L CD2 1 
ATOM   5643 N NE1 . TRP D 2 101 ? 16.807  -1.235  29.866  1.00 13.51  ? 101 TRP L NE1 1 
ATOM   5644 C CE2 . TRP D 2 101 ? 17.217  -0.298  30.760  1.00 12.66  ? 101 TRP L CE2 1 
ATOM   5645 C CE3 . TRP D 2 101 ? 16.646  0.394   32.983  1.00 12.80  ? 101 TRP L CE3 1 
ATOM   5646 C CZ2 . TRP D 2 101 ? 18.268  0.622   30.688  1.00 14.06  ? 101 TRP L CZ2 1 
ATOM   5647 C CZ3 . TRP D 2 101 ? 17.679  1.308   32.923  1.00 12.55  ? 101 TRP L CZ3 1 
ATOM   5648 C CH2 . TRP D 2 101 ? 18.496  1.400   31.805  1.00 13.67  ? 101 TRP L CH2 1 
ATOM   5649 N N   . THR D 2 102 ? 13.664  -4.744  34.184  1.00 13.25  ? 102 THR L N   1 
ATOM   5650 C CA  . THR D 2 102 ? 13.322  -5.075  35.550  1.00 14.10  ? 102 THR L CA  1 
ATOM   5651 C C   . THR D 2 102 ? 14.592  -5.191  36.368  1.00 14.08  ? 102 THR L C   1 
ATOM   5652 O O   . THR D 2 102 ? 15.527  -5.898  35.966  1.00 14.67  ? 102 THR L O   1 
ATOM   5653 C CB  . THR D 2 102 ? 12.575  -6.401  35.706  1.00 14.35  ? 102 THR L CB  1 
ATOM   5654 O OG1 . THR D 2 102 ? 11.678  -6.496  34.614  1.00 13.01  ? 102 THR L OG1 1 
ATOM   5655 C CG2 . THR D 2 102 ? 11.831  -6.497  37.023  1.00 15.33  ? 102 THR L CG2 1 
ATOM   5656 N N   . PHE D 2 103 ? 14.582  -4.510  37.520  1.00 13.79  ? 103 PHE L N   1 
ATOM   5657 C CA  . PHE D 2 103 ? 15.697  -4.584  38.440  1.00 14.35  ? 103 PHE L CA  1 
ATOM   5658 C C   . PHE D 2 103 ? 15.393  -5.595  39.529  1.00 13.67  ? 103 PHE L C   1 
ATOM   5659 O O   . PHE D 2 103 ? 14.256  -5.655  39.965  1.00 14.02  ? 103 PHE L O   1 
ATOM   5660 C CB  . PHE D 2 103 ? 15.933  -3.237  39.111  1.00 14.65  ? 103 PHE L CB  1 
ATOM   5661 C CG  . PHE D 2 103 ? 16.597  -2.219  38.238  1.00 14.55  ? 103 PHE L CG  1 
ATOM   5662 C CD1 . PHE D 2 103 ? 17.952  -2.281  38.018  1.00 14.74  ? 103 PHE L CD1 1 
ATOM   5663 C CD2 . PHE D 2 103 ? 15.853  -1.215  37.640  1.00 14.54  ? 103 PHE L CD2 1 
ATOM   5664 C CE1 . PHE D 2 103 ? 18.565  -1.351  37.207  1.00 14.27  ? 103 PHE L CE1 1 
ATOM   5665 C CE2 . PHE D 2 103 ? 16.468  -0.277  36.842  1.00 15.36  ? 103 PHE L CE2 1 
ATOM   5666 C CZ  . PHE D 2 103 ? 17.828  -0.349  36.630  1.00 15.94  ? 103 PHE L CZ  1 
ATOM   5667 N N   . GLY D 2 104 ? 16.404  -6.364  39.958  1.00 13.96  ? 104 GLY L N   1 
ATOM   5668 C CA  . GLY D 2 104 ? 16.333  -7.065  41.227  1.00 14.39  ? 104 GLY L CA  1 
ATOM   5669 C C   . GLY D 2 104 ? 16.164  -6.075  42.394  1.00 16.82  ? 104 GLY L C   1 
ATOM   5670 O O   . GLY D 2 104 ? 16.450  -4.872  42.279  1.00 16.92  ? 104 GLY L O   1 
ATOM   5671 N N   . GLY D 2 105 ? 15.797  -6.626  43.555  1.00 17.86  ? 105 GLY L N   1 
ATOM   5672 C CA  . GLY D 2 105 ? 15.539  -5.862  44.767  1.00 16.86  ? 105 GLY L CA  1 
ATOM   5673 C C   . GLY D 2 105 ? 16.823  -5.294  45.366  1.00 16.98  ? 105 GLY L C   1 
ATOM   5674 O O   . GLY D 2 105 ? 16.760  -4.477  46.260  1.00 16.41  ? 105 GLY L O   1 
ATOM   5675 N N   . GLY D 2 106 ? 17.985  -5.796  44.937  1.00 18.18  ? 106 GLY L N   1 
ATOM   5676 C CA  . GLY D 2 106 ? 19.259  -5.317  45.445  1.00 19.28  ? 106 GLY L CA  1 
ATOM   5677 C C   . GLY D 2 106 ? 19.836  -6.201  46.551  1.00 20.52  ? 106 GLY L C   1 
ATOM   5678 O O   . GLY D 2 106 ? 19.086  -6.817  47.303  1.00 19.82  ? 106 GLY L O   1 
ATOM   5679 N N   . THR D 2 107 ? 21.173  -6.227  46.652  1.00 21.20  ? 107 THR L N   1 
ATOM   5680 C CA  . THR D 2 107 ? 21.877  -6.910  47.733  1.00 21.98  ? 107 THR L CA  1 
ATOM   5681 C C   . THR D 2 107 ? 22.908  -5.970  48.360  1.00 22.67  ? 107 THR L C   1 
ATOM   5682 O O   . THR D 2 107 ? 23.829  -5.496  47.681  1.00 18.96  ? 107 THR L O   1 
ATOM   5683 C CB  . THR D 2 107 ? 22.631  -8.150  47.230  1.00 23.53  ? 107 THR L CB  1 
ATOM   5684 O OG1 . THR D 2 107 ? 21.718  -9.103  46.689  1.00 24.12  ? 107 THR L OG1 1 
ATOM   5685 C CG2 . THR D 2 107 ? 23.422  -8.823  48.319  1.00 24.38  ? 107 THR L CG2 1 
ATOM   5686 N N   . LYS D 2 108 ? 22.734  -5.711  49.658  1.00 22.11  ? 108 LYS L N   1 
ATOM   5687 C CA  . LYS D 2 108 ? 23.646  -4.879  50.410  1.00 25.28  ? 108 LYS L CA  1 
ATOM   5688 C C   . LYS D 2 108 ? 24.867  -5.715  50.790  1.00 22.48  ? 108 LYS L C   1 
ATOM   5689 O O   . LYS D 2 108 ? 24.734  -6.724  51.471  1.00 23.79  ? 108 LYS L O   1 
ATOM   5690 C CB  . LYS D 2 108 ? 22.920  -4.322  51.642  1.00 29.60  ? 108 LYS L CB  1 
ATOM   5691 C CG  . LYS D 2 108 ? 23.401  -2.968  52.166  1.00 38.57  ? 108 LYS L CG  1 
ATOM   5692 C CD  . LYS D 2 108 ? 24.883  -2.692  51.958  1.00 46.80  ? 108 LYS L CD  1 
ATOM   5693 C CE  . LYS D 2 108 ? 25.346  -1.335  52.460  1.00 52.55  ? 108 LYS L CE  1 
ATOM   5694 N NZ  . LYS D 2 108 ? 26.827  -1.278  52.532  1.00 49.58  ? 108 LYS L NZ  1 
ATOM   5695 N N   . LEU D 2 109 ? 26.052  -5.314  50.332  1.00 21.74  ? 109 LEU L N   1 
ATOM   5696 C CA  . LEU D 2 109 ? 27.279  -6.016  50.681  1.00 23.91  ? 109 LEU L CA  1 
ATOM   5697 C C   . LEU D 2 109 ? 28.021  -5.213  51.752  1.00 25.45  ? 109 LEU L C   1 
ATOM   5698 O O   . LEU D 2 109 ? 28.315  -4.043  51.526  1.00 28.49  ? 109 LEU L O   1 
ATOM   5699 C CB  . LEU D 2 109 ? 28.128  -6.191  49.418  1.00 24.74  ? 109 LEU L CB  1 
ATOM   5700 C CG  . LEU D 2 109 ? 29.476  -6.888  49.599  1.00 28.19  ? 109 LEU L CG  1 
ATOM   5701 C CD1 . LEU D 2 109 ? 29.307  -8.388  49.740  1.00 30.73  ? 109 LEU L CD1 1 
ATOM   5702 C CD2 . LEU D 2 109 ? 30.379  -6.612  48.418  1.00 30.98  ? 109 LEU L CD2 1 
ATOM   5703 N N   . GLU D 2 110 ? 28.302  -5.857  52.899  1.00 26.33  ? 110 GLU L N   1 
ATOM   5704 C CA  . GLU D 2 110 ? 29.010  -5.280  54.038  1.00 27.89  ? 110 GLU L CA  1 
ATOM   5705 C C   . GLU D 2 110 ? 30.254  -6.125  54.384  1.00 28.75  ? 110 GLU L C   1 
ATOM   5706 O O   . GLU D 2 110 ? 30.405  -7.258  53.924  1.00 23.16  ? 110 GLU L O   1 
ATOM   5707 C CB  . GLU D 2 110 ? 28.056  -5.184  55.236  1.00 29.92  ? 110 GLU L CB  1 
ATOM   5708 C CG  . GLU D 2 110 ? 27.772  -6.515  55.919  1.00 36.56  ? 110 GLU L CG  1 
ATOM   5709 C CD  . GLU D 2 110 ? 26.837  -6.481  57.125  1.00 43.90  ? 110 GLU L CD  1 
ATOM   5710 O OE1 . GLU D 2 110 ? 26.121  -5.473  57.308  1.00 44.88  ? 110 GLU L OE1 1 
ATOM   5711 O OE2 . GLU D 2 110 ? 26.816  -7.469  57.882  1.00 48.02  ? 110 GLU L OE2 1 
ATOM   5712 N N   . ILE D 2 111 ? 31.149  -5.581  55.222  1.00 26.53  ? 111 ILE L N   1 
ATOM   5713 C CA  . ILE D 2 111 ? 32.334  -6.316  55.638  1.00 27.83  ? 111 ILE L CA  1 
ATOM   5714 C C   . ILE D 2 111 ? 32.023  -7.133  56.890  1.00 27.22  ? 111 ILE L C   1 
ATOM   5715 O O   . ILE D 2 111 ? 31.399  -6.654  57.833  1.00 25.83  ? 111 ILE L O   1 
ATOM   5716 C CB  . ILE D 2 111 ? 33.515  -5.362  55.872  1.00 28.27  ? 111 ILE L CB  1 
ATOM   5717 C CG1 . ILE D 2 111 ? 33.940  -4.723  54.556  1.00 28.97  ? 111 ILE L CG1 1 
ATOM   5718 C CG2 . ILE D 2 111 ? 34.676  -6.074  56.569  1.00 26.97  ? 111 ILE L CG2 1 
ATOM   5719 C CD1 . ILE D 2 111 ? 35.037  -3.705  54.703  1.00 31.33  ? 111 ILE L CD1 1 
ATOM   5720 N N   . LYS D 2 112 ? 32.459  -8.389  56.885  1.00 31.08  ? 112 LYS L N   1 
ATOM   5721 C CA  . LYS D 2 112 ? 32.262  -9.262  58.036  1.00 34.65  ? 112 LYS L CA  1 
ATOM   5722 C C   . LYS D 2 112 ? 33.389  -9.017  59.041  1.00 30.00  ? 112 LYS L C   1 
ATOM   5723 O O   . LYS D 2 112 ? 34.543  -8.952  58.654  1.00 29.73  ? 112 LYS L O   1 
ATOM   5724 C CB  . LYS D 2 112 ? 32.263  -10.735 57.621  1.00 34.35  ? 112 LYS L CB  1 
ATOM   5725 C CG  . LYS D 2 112 ? 32.019  -11.739 58.741  1.00 38.51  ? 112 LYS L CG  1 
ATOM   5726 C CD  . LYS D 2 112 ? 32.805  -13.043 58.610  1.00 44.08  ? 112 LYS L CD  1 
ATOM   5727 C CE  . LYS D 2 112 ? 32.457  -13.881 57.399  1.00 48.26  ? 112 LYS L CE  1 
ATOM   5728 N NZ  . LYS D 2 112 ? 31.030  -14.278 57.408  1.00 50.47  ? 112 LYS L NZ  1 
ATOM   5729 N N   . ARG D 2 113 ? 33.023  -8.874  60.316  1.00 35.81  ? 113 ARG L N   1 
ATOM   5730 C CA  . ARG D 2 113 ? 33.946  -8.821  61.447  1.00 39.77  ? 113 ARG L CA  1 
ATOM   5731 C C   . ARG D 2 113 ? 33.350  -9.667  62.575  1.00 40.83  ? 113 ARG L C   1 
ATOM   5732 O O   . ARG D 2 113 ? 32.294  -10.262 62.385  1.00 40.81  ? 113 ARG L O   1 
ATOM   5733 C CB  . ARG D 2 113 ? 34.150  -7.370  61.899  1.00 36.37  ? 113 ARG L CB  1 
ATOM   5734 C CG  . ARG D 2 113 ? 32.840  -6.642  62.158  1.00 37.06  ? 113 ARG L CG  1 
ATOM   5735 C CD  . ARG D 2 113 ? 32.974  -5.496  63.136  1.00 38.91  ? 113 ARG L CD  1 
ATOM   5736 N NE  . ARG D 2 113 ? 33.259  -5.996  64.464  1.00 40.27  ? 113 ARG L NE  1 
ATOM   5737 C CZ  . ARG D 2 113 ? 34.142  -5.497  65.329  1.00 41.33  ? 113 ARG L CZ  1 
ATOM   5738 N NH1 . ARG D 2 113 ? 34.420  -6.191  66.421  1.00 37.44  ? 113 ARG L NH1 1 
ATOM   5739 N NH2 . ARG D 2 113 ? 34.753  -4.340  65.106  1.00 38.55  ? 113 ARG L NH2 1 
ATOM   5740 N N   . THR D 2 114 ? 33.995  -9.693  63.755  1.00 47.05  ? 114 THR L N   1 
ATOM   5741 C CA  . THR D 2 114 ? 33.482  -10.444 64.897  1.00 45.48  ? 114 THR L CA  1 
ATOM   5742 C C   . THR D 2 114 ? 32.342  -9.699  65.568  1.00 45.42  ? 114 THR L C   1 
ATOM   5743 O O   . THR D 2 114 ? 32.205  -8.482  65.409  1.00 47.97  ? 114 THR L O   1 
ATOM   5744 C CB  . THR D 2 114 ? 34.504  -10.612 66.027  1.00 47.46  ? 114 THR L CB  1 
ATOM   5745 O OG1 . THR D 2 114 ? 34.559  -9.330  66.659  1.00 45.56  ? 114 THR L OG1 1 
ATOM   5746 C CG2 . THR D 2 114 ? 35.867  -11.076 65.560  1.00 40.18  ? 114 THR L CG2 1 
ATOM   5747 N N   . VAL D 2 115 ? 31.584  -10.422 66.395  1.00 42.61  ? 115 VAL L N   1 
ATOM   5748 C CA  . VAL D 2 115 ? 30.467  -9.820  67.105  1.00 41.78  ? 115 VAL L CA  1 
ATOM   5749 C C   . VAL D 2 115 ? 31.057  -8.791  68.075  1.00 39.85  ? 115 VAL L C   1 
ATOM   5750 O O   . VAL D 2 115 ? 32.239  -8.857  68.417  1.00 35.91  ? 115 VAL L O   1 
ATOM   5751 C CB  . VAL D 2 115 ? 29.570  -10.907 67.757  1.00 45.86  ? 115 VAL L CB  1 
ATOM   5752 C CG1 . VAL D 2 115 ? 28.432  -10.354 68.608  1.00 46.16  ? 115 VAL L CG1 1 
ATOM   5753 C CG2 . VAL D 2 115 ? 28.973  -11.851 66.712  1.00 45.44  ? 115 VAL L CG2 1 
ATOM   5754 N N   . ALA D 2 116 ? 30.249  -7.776  68.411  1.00 38.33  ? 116 ALA L N   1 
ATOM   5755 C CA  . ALA D 2 116 ? 30.633  -6.699  69.317  1.00 39.38  ? 116 ALA L CA  1 
ATOM   5756 C C   . ALA D 2 116 ? 29.368  -6.092  69.905  1.00 41.66  ? 116 ALA L C   1 
ATOM   5757 O O   . ALA D 2 116 ? 28.505  -5.606  69.167  1.00 49.63  ? 116 ALA L O   1 
ATOM   5758 C CB  . ALA D 2 116 ? 31.430  -5.645  68.599  1.00 39.80  ? 116 ALA L CB  1 
ATOM   5759 N N   . ALA D 2 117 ? 29.227  -6.147  71.230  1.00 41.58  ? 117 ALA L N   1 
ATOM   5760 C CA  . ALA D 2 117 ? 27.987  -5.686  71.833  1.00 40.49  ? 117 ALA L CA  1 
ATOM   5761 C C   . ALA D 2 117 ? 27.988  -4.168  71.792  1.00 38.10  ? 117 ALA L C   1 
ATOM   5762 O O   . ALA D 2 117 ? 29.044  -3.550  71.660  1.00 39.46  ? 117 ALA L O   1 
ATOM   5763 C CB  . ALA D 2 117 ? 27.838  -6.193  73.249  1.00 44.00  ? 117 ALA L CB  1 
ATOM   5764 N N   . PRO D 2 118 ? 26.804  -3.538  71.888  1.00 39.41  ? 118 PRO L N   1 
ATOM   5765 C CA  . PRO D 2 118 ? 26.723  -2.088  71.963  1.00 42.08  ? 118 PRO L CA  1 
ATOM   5766 C C   . PRO D 2 118 ? 27.139  -1.603  73.355  1.00 51.58  ? 118 PRO L C   1 
ATOM   5767 O O   . PRO D 2 118 ? 26.775  -2.210  74.360  1.00 59.93  ? 118 PRO L O   1 
ATOM   5768 C CB  . PRO D 2 118 ? 25.250  -1.751  71.649  1.00 45.07  ? 118 PRO L CB  1 
ATOM   5769 C CG  . PRO D 2 118 ? 24.481  -3.081  71.682  1.00 41.83  ? 118 PRO L CG  1 
ATOM   5770 C CD  . PRO D 2 118 ? 25.487  -4.192  71.921  1.00 39.17  ? 118 PRO L CD  1 
ATOM   5771 N N   . SER D 2 119 ? 27.930  -0.522  73.404  1.00 46.25  ? 119 SER L N   1 
ATOM   5772 C CA  . SER D 2 119 ? 27.972  0.341   74.572  1.00 38.02  ? 119 SER L CA  1 
ATOM   5773 C C   . SER D 2 119 ? 26.721  1.209   74.560  1.00 35.83  ? 119 SER L C   1 
ATOM   5774 O O   . SER D 2 119 ? 26.403  1.823   73.548  1.00 35.93  ? 119 SER L O   1 
ATOM   5775 C CB  . SER D 2 119 ? 29.231  1.163   74.561  1.00 37.18  ? 119 SER L CB  1 
ATOM   5776 O OG  . SER D 2 119 ? 30.362  0.323   74.426  1.00 33.94  ? 119 SER L OG  1 
ATOM   5777 N N   . VAL D 2 120 ? 25.968  1.235   75.661  1.00 35.72  ? 120 VAL L N   1 
ATOM   5778 C CA  . VAL D 2 120 ? 24.704  1.963   75.665  1.00 35.21  ? 120 VAL L CA  1 
ATOM   5779 C C   . VAL D 2 120 ? 24.857  3.184   76.561  1.00 31.16  ? 120 VAL L C   1 
ATOM   5780 O O   . VAL D 2 120 ? 25.589  3.113   77.537  1.00 33.64  ? 120 VAL L O   1 
ATOM   5781 C CB  . VAL D 2 120 ? 23.510  1.082   76.098  1.00 36.43  ? 120 VAL L CB  1 
ATOM   5782 C CG1 . VAL D 2 120 ? 22.165  1.767   75.874  1.00 36.18  ? 120 VAL L CG1 1 
ATOM   5783 C CG2 . VAL D 2 120 ? 23.542  -0.262  75.388  1.00 41.25  ? 120 VAL L CG2 1 
ATOM   5784 N N   . PHE D 2 121 ? 24.141  4.267   76.217  1.00 31.34  ? 121 PHE L N   1 
ATOM   5785 C CA  . PHE D 2 121 ? 24.188  5.533   76.943  1.00 34.18  ? 121 PHE L CA  1 
ATOM   5786 C C   . PHE D 2 121 ? 22.814  6.191   76.829  1.00 35.27  ? 121 PHE L C   1 
ATOM   5787 O O   . PHE D 2 121 ? 22.258  6.141   75.735  1.00 39.38  ? 121 PHE L O   1 
ATOM   5788 C CB  . PHE D 2 121 ? 25.264  6.471   76.351  1.00 31.73  ? 121 PHE L CB  1 
ATOM   5789 C CG  . PHE D 2 121 ? 26.666  5.907   76.260  1.00 32.08  ? 121 PHE L CG  1 
ATOM   5790 C CD1 . PHE D 2 121 ? 27.053  5.105   75.200  1.00 28.46  ? 121 PHE L CD1 1 
ATOM   5791 C CD2 . PHE D 2 121 ? 27.605  6.176   77.253  1.00 33.32  ? 121 PHE L CD2 1 
ATOM   5792 C CE1 . PHE D 2 121 ? 28.333  4.573   75.135  1.00 31.05  ? 121 PHE L CE1 1 
ATOM   5793 C CE2 . PHE D 2 121 ? 28.881  5.637   77.196  1.00 31.38  ? 121 PHE L CE2 1 
ATOM   5794 C CZ  . PHE D 2 121 ? 29.253  4.852   76.121  1.00 33.68  ? 121 PHE L CZ  1 
ATOM   5795 N N   . ILE D 2 122 ? 22.274  6.813   77.903  1.00 37.93  ? 122 ILE L N   1 
ATOM   5796 C CA  . ILE D 2 122 ? 21.084  7.661   77.781  1.00 42.38  ? 122 ILE L CA  1 
ATOM   5797 C C   . ILE D 2 122 ? 21.422  9.127   78.031  1.00 40.65  ? 122 ILE L C   1 
ATOM   5798 O O   . ILE D 2 122 ? 22.290  9.451   78.827  1.00 49.39  ? 122 ILE L O   1 
ATOM   5799 C CB  . ILE D 2 122 ? 19.907  7.283   78.708  1.00 51.52  ? 122 ILE L CB  1 
ATOM   5800 C CG1 . ILE D 2 122 ? 20.360  6.709   80.051  1.00 56.01  ? 122 ILE L CG1 1 
ATOM   5801 C CG2 . ILE D 2 122 ? 18.926  6.364   78.006  1.00 59.32  ? 122 ILE L CG2 1 
ATOM   5802 C CD1 . ILE D 2 122 ? 21.090  7.690   80.942  1.00 59.31  ? 122 ILE L CD1 1 
ATOM   5803 N N   . PHE D 2 123 ? 20.622  9.996   77.412  1.00 43.41  ? 123 PHE L N   1 
ATOM   5804 C CA  . PHE D 2 123 ? 20.731  11.433  77.557  1.00 43.76  ? 123 PHE L CA  1 
ATOM   5805 C C   . PHE D 2 123 ? 19.352  12.013  77.879  1.00 48.68  ? 123 PHE L C   1 
ATOM   5806 O O   . PHE D 2 123 ? 18.427  11.991  77.054  1.00 46.06  ? 123 PHE L O   1 
ATOM   5807 C CB  . PHE D 2 123 ? 21.291  12.052  76.275  1.00 45.50  ? 123 PHE L CB  1 
ATOM   5808 C CG  . PHE D 2 123 ? 22.645  11.536  75.868  1.00 45.48  ? 123 PHE L CG  1 
ATOM   5809 C CD1 . PHE D 2 123 ? 23.801  12.017  76.473  1.00 46.08  ? 123 PHE L CD1 1 
ATOM   5810 C CD2 . PHE D 2 123 ? 22.764  10.561  74.892  1.00 43.02  ? 123 PHE L CD2 1 
ATOM   5811 C CE1 . PHE D 2 123 ? 25.051  11.540  76.104  1.00 40.88  ? 123 PHE L CE1 1 
ATOM   5812 C CE2 . PHE D 2 123 ? 24.017  10.096  74.514  1.00 45.89  ? 123 PHE L CE2 1 
ATOM   5813 C CZ  . PHE D 2 123 ? 25.157  10.581  75.127  1.00 43.25  ? 123 PHE L CZ  1 
ATOM   5814 N N   . PRO D 2 124 ? 19.165  12.555  79.099  1.00 44.68  ? 124 PRO L N   1 
ATOM   5815 C CA  . PRO D 2 124 ? 17.989  13.370  79.388  1.00 42.12  ? 124 PRO L CA  1 
ATOM   5816 C C   . PRO D 2 124 ? 17.893  14.613  78.517  1.00 43.64  ? 124 PRO L C   1 
ATOM   5817 O O   . PRO D 2 124 ? 18.883  15.079  77.977  1.00 45.81  ? 124 PRO L O   1 
ATOM   5818 C CB  . PRO D 2 124 ? 18.190  13.807  80.849  1.00 45.51  ? 124 PRO L CB  1 
ATOM   5819 C CG  . PRO D 2 124 ? 19.657  13.526  81.149  1.00 46.75  ? 124 PRO L CG  1 
ATOM   5820 C CD  . PRO D 2 124 ? 20.027  12.349  80.275  1.00 45.24  ? 124 PRO L CD  1 
ATOM   5821 N N   . PRO D 2 125 ? 16.705  15.229  78.385  1.00 43.29  ? 125 PRO L N   1 
ATOM   5822 C CA  . PRO D 2 125 ? 16.597  16.492  77.666  1.00 45.26  ? 125 PRO L CA  1 
ATOM   5823 C C   . PRO D 2 125 ? 17.318  17.623  78.393  1.00 47.03  ? 125 PRO L C   1 
ATOM   5824 O O   . PRO D 2 125 ? 17.452  17.608  79.613  1.00 44.16  ? 125 PRO L O   1 
ATOM   5825 C CB  . PRO D 2 125 ? 15.085  16.757  77.595  1.00 49.83  ? 125 PRO L CB  1 
ATOM   5826 C CG  . PRO D 2 125 ? 14.474  15.890  78.695  1.00 48.75  ? 125 PRO L CG  1 
ATOM   5827 C CD  . PRO D 2 125 ? 15.418  14.725  78.879  1.00 45.37  ? 125 PRO L CD  1 
ATOM   5828 N N   . SER D 2 126 ? 17.776  18.611  77.621  1.00 43.93  ? 126 SER L N   1 
ATOM   5829 C CA  . SER D 2 126 ? 18.449  19.769  78.175  1.00 45.32  ? 126 SER L CA  1 
ATOM   5830 C C   . SER D 2 126 ? 17.416  20.737  78.761  1.00 45.28  ? 126 SER L C   1 
ATOM   5831 O O   . SER D 2 126 ? 16.255  20.781  78.331  1.00 46.31  ? 126 SER L O   1 
ATOM   5832 C CB  . SER D 2 126 ? 19.309  20.437  77.111  1.00 43.80  ? 126 SER L CB  1 
ATOM   5833 O OG  . SER D 2 126 ? 18.504  21.064  76.112  1.00 42.07  ? 126 SER L OG  1 
ATOM   5834 N N   . ASP D 2 127 ? 17.871  21.557  79.707  1.00 44.10  ? 127 ASP L N   1 
ATOM   5835 C CA  . ASP D 2 127 ? 17.043  22.620  80.246  1.00 47.65  ? 127 ASP L CA  1 
ATOM   5836 C C   . ASP D 2 127 ? 16.723  23.606  79.120  1.00 47.59  ? 127 ASP L C   1 
ATOM   5837 O O   . ASP D 2 127 ? 15.588  24.073  79.041  1.00 45.50  ? 127 ASP L O   1 
ATOM   5838 C CB  . ASP D 2 127 ? 17.678  23.259  81.492  1.00 50.87  ? 127 ASP L CB  1 
ATOM   5839 C CG  . ASP D 2 127 ? 17.943  22.280  82.636  1.00 53.94  ? 127 ASP L CG  1 
ATOM   5840 O OD1 . ASP D 2 127 ? 17.075  21.416  82.884  1.00 58.58  ? 127 ASP L OD1 1 
ATOM   5841 O OD2 . ASP D 2 127 ? 19.024  22.372  83.272  1.00 54.82  ? 127 ASP L OD2 1 
ATOM   5842 N N   . GLU D 2 128 ? 17.692  23.877  78.222  1.00 49.85  ? 128 GLU L N   1 
ATOM   5843 C CA  . GLU D 2 128 ? 17.470  24.774  77.091  1.00 48.78  ? 128 GLU L CA  1 
ATOM   5844 C C   . GLU D 2 128 ? 16.232  24.346  76.307  1.00 46.47  ? 128 GLU L C   1 
ATOM   5845 O O   . GLU D 2 128 ? 15.364  25.158  75.991  1.00 46.17  ? 128 GLU L O   1 
ATOM   5846 C CB  . GLU D 2 128 ? 18.612  24.754  76.075  1.00 59.12  ? 128 GLU L CB  1 
ATOM   5847 C CG  . GLU D 2 128 ? 19.946  25.241  76.600  1.00 68.18  ? 128 GLU L CG  1 
ATOM   5848 C CD  . GLU D 2 128 ? 21.123  24.791  75.751  1.00 72.65  ? 128 GLU L CD  1 
ATOM   5849 O OE1 . GLU D 2 128 ? 21.008  24.849  74.493  1.00 64.61  ? 128 GLU L OE1 1 
ATOM   5850 O OE2 . GLU D 2 128 ? 22.153  24.384  76.349  1.00 71.52  ? 128 GLU L OE2 1 
ATOM   5851 N N   . GLN D 2 129 ? 16.162  23.054  75.978  1.00 43.77  ? 129 GLN L N   1 
ATOM   5852 C CA  . GLN D 2 129 ? 15.079  22.565  75.140  1.00 43.92  ? 129 GLN L CA  1 
ATOM   5853 C C   . GLN D 2 129 ? 13.750  22.624  75.903  1.00 45.14  ? 129 GLN L C   1 
ATOM   5854 O O   . GLN D 2 129 ? 12.760  23.126  75.366  1.00 44.60  ? 129 GLN L O   1 
ATOM   5855 C CB  . GLN D 2 129 ? 15.400  21.162  74.638  1.00 41.44  ? 129 GLN L CB  1 
ATOM   5856 C CG  . GLN D 2 129 ? 14.417  20.704  73.581  1.00 44.39  ? 129 GLN L CG  1 
ATOM   5857 C CD  . GLN D 2 129 ? 14.372  19.210  73.391  1.00 38.41  ? 129 GLN L CD  1 
ATOM   5858 O OE1 . GLN D 2 129 ? 14.905  18.430  74.179  1.00 39.28  ? 129 GLN L OE1 1 
ATOM   5859 N NE2 . GLN D 2 129 ? 13.685  18.814  72.335  1.00 40.01  ? 129 GLN L NE2 1 
ATOM   5860 N N   . LEU D 2 130 ? 13.742  22.147  77.159  1.00 49.44  ? 130 LEU L N   1 
ATOM   5861 C CA  . LEU D 2 130 ? 12.537  22.130  77.987  1.00 55.49  ? 130 LEU L CA  1 
ATOM   5862 C C   . LEU D 2 130 ? 11.887  23.511  78.050  1.00 61.03  ? 130 LEU L C   1 
ATOM   5863 O O   . LEU D 2 130 ? 10.663  23.595  78.125  1.00 57.64  ? 130 LEU L O   1 
ATOM   5864 C CB  . LEU D 2 130 ? 12.873  21.625  79.395  1.00 54.67  ? 130 LEU L CB  1 
ATOM   5865 C CG  . LEU D 2 130 ? 13.215  20.139  79.490  1.00 57.12  ? 130 LEU L CG  1 
ATOM   5866 C CD1 . LEU D 2 130 ? 13.277  19.682  80.940  1.00 62.63  ? 130 LEU L CD1 1 
ATOM   5867 C CD2 . LEU D 2 130 ? 12.209  19.304  78.726  1.00 56.75  ? 130 LEU L CD2 1 
ATOM   5868 N N   . LYS D 2 131 ? 12.709  24.573  77.975  1.00 67.31  ? 131 LYS L N   1 
ATOM   5869 C CA  . LYS D 2 131 ? 12.244  25.952  78.036  1.00 68.23  ? 131 LYS L CA  1 
ATOM   5870 C C   . LYS D 2 131 ? 11.277  26.285  76.893  1.00 65.22  ? 131 LYS L C   1 
ATOM   5871 O O   . LYS D 2 131 ? 10.369  27.097  77.079  1.00 68.77  ? 131 LYS L O   1 
ATOM   5872 C CB  . LYS D 2 131 ? 13.442  26.910  78.042  1.00 76.22  ? 131 LYS L CB  1 
ATOM   5873 C CG  . LYS D 2 131 ? 13.137  28.303  78.576  1.00 83.76  ? 131 LYS L CG  1 
ATOM   5874 C CD  . LYS D 2 131 ? 12.861  28.342  80.078  1.00 86.78  ? 131 LYS L CD  1 
ATOM   5875 C CE  . LYS D 2 131 ? 11.654  29.177  80.461  1.00 88.21  ? 131 LYS L CE  1 
ATOM   5876 N NZ  . LYS D 2 131 ? 11.684  30.534  79.861  1.00 87.99  ? 131 LYS L NZ  1 
ATOM   5877 N N   . SER D 2 132 ? 11.452  25.672  75.714  1.00 63.26  ? 132 SER L N   1 
ATOM   5878 C CA  . SER D 2 132 ? 10.579  25.947  74.579  1.00 63.78  ? 132 SER L CA  1 
ATOM   5879 C C   . SER D 2 132 ? 9.450   24.919  74.494  1.00 65.34  ? 132 SER L C   1 
ATOM   5880 O O   . SER D 2 132 ? 8.676   24.932  73.540  1.00 64.05  ? 132 SER L O   1 
ATOM   5881 C CB  . SER D 2 132 ? 11.359  26.034  73.293  1.00 65.93  ? 132 SER L CB  1 
ATOM   5882 O OG  . SER D 2 132 ? 12.205  24.906  73.130  1.00 71.96  ? 132 SER L OG  1 
ATOM   5883 N N   . GLY D 2 133 ? 9.374   24.021  75.487  1.00 68.82  ? 133 GLY L N   1 
ATOM   5884 C CA  . GLY D 2 133 ? 8.145   23.300  75.791  1.00 65.27  ? 133 GLY L CA  1 
ATOM   5885 C C   . GLY D 2 133 ? 8.059   21.934  75.117  1.00 57.92  ? 133 GLY L C   1 
ATOM   5886 O O   . GLY D 2 133 ? 6.975   21.373  74.973  1.00 57.03  ? 133 GLY L O   1 
ATOM   5887 N N   . THR D 2 134 ? 9.208   21.399  74.713  1.00 58.39  ? 134 THR L N   1 
ATOM   5888 C CA  . THR D 2 134 ? 9.268   20.039  74.207  1.00 57.05  ? 134 THR L CA  1 
ATOM   5889 C C   . THR D 2 134 ? 10.459  19.359  74.861  1.00 53.57  ? 134 THR L C   1 
ATOM   5890 O O   . THR D 2 134 ? 11.367  20.032  75.348  1.00 59.75  ? 134 THR L O   1 
ATOM   5891 C CB  . THR D 2 134 ? 9.405   19.968  72.678  1.00 59.52  ? 134 THR L CB  1 
ATOM   5892 O OG1 . THR D 2 134 ? 10.788  20.169  72.385  1.00 67.12  ? 134 THR L OG1 1 
ATOM   5893 C CG2 . THR D 2 134 ? 8.550   20.967  71.926  1.00 56.78  ? 134 THR L CG2 1 
ATOM   5894 N N   . ALA D 2 135 ? 10.450  18.026  74.832  1.00 47.70  ? 135 ALA L N   1 
ATOM   5895 C CA  . ALA D 2 135 ? 11.461  17.245  75.511  1.00 45.35  ? 135 ALA L CA  1 
ATOM   5896 C C   . ALA D 2 135 ? 11.855  16.073  74.625  1.00 44.87  ? 135 ALA L C   1 
ATOM   5897 O O   . ALA D 2 135 ? 11.009  15.230  74.334  1.00 42.70  ? 135 ALA L O   1 
ATOM   5898 C CB  . ALA D 2 135 ? 10.925  16.769  76.837  1.00 45.33  ? 135 ALA L CB  1 
ATOM   5899 N N   . SER D 2 136 ? 13.137  16.037  74.221  1.00 40.68  ? 136 SER L N   1 
ATOM   5900 C CA  . SER D 2 136 ? 13.684  14.920  73.463  1.00 40.44  ? 136 SER L CA  1 
ATOM   5901 C C   . SER D 2 136 ? 14.627  14.131  74.363  1.00 38.10  ? 136 SER L C   1 
ATOM   5902 O O   . SER D 2 136 ? 15.594  14.679  74.899  1.00 38.63  ? 136 SER L O   1 
ATOM   5903 C CB  . SER D 2 136 ? 14.388  15.380  72.205  1.00 41.81  ? 136 SER L CB  1 
ATOM   5904 O OG  . SER D 2 136 ? 13.600  16.307  71.465  1.00 37.05  ? 136 SER L OG  1 
ATOM   5905 N N   . VAL D 2 137 ? 14.304  12.856  74.568  1.00 36.05  ? 137 VAL L N   1 
ATOM   5906 C CA  . VAL D 2 137 ? 15.165  11.946  75.308  1.00 35.08  ? 137 VAL L CA  1 
ATOM   5907 C C   . VAL D 2 137 ? 15.862  11.082  74.269  1.00 36.65  ? 137 VAL L C   1 
ATOM   5908 O O   . VAL D 2 137 ? 15.190  10.635  73.346  1.00 34.49  ? 137 VAL L O   1 
ATOM   5909 C CB  . VAL D 2 137 ? 14.366  11.062  76.282  1.00 33.74  ? 137 VAL L CB  1 
ATOM   5910 C CG1 . VAL D 2 137 ? 15.269  10.326  77.262  1.00 35.28  ? 137 VAL L CG1 1 
ATOM   5911 C CG2 . VAL D 2 137 ? 13.321  11.878  77.026  1.00 38.58  ? 137 VAL L CG2 1 
ATOM   5912 N N   . VAL D 2 138 ? 17.176  10.840  74.430  1.00 39.37  ? 138 VAL L N   1 
ATOM   5913 C CA  . VAL D 2 138 ? 17.941  10.107  73.430  1.00 40.71  ? 138 VAL L CA  1 
ATOM   5914 C C   . VAL D 2 138 ? 18.683  8.939   74.072  1.00 38.35  ? 138 VAL L C   1 
ATOM   5915 O O   . VAL D 2 138 ? 19.260  9.072   75.142  1.00 42.80  ? 138 VAL L O   1 
ATOM   5916 C CB  . VAL D 2 138 ? 18.916  11.031  72.678  1.00 41.43  ? 138 VAL L CB  1 
ATOM   5917 C CG1 . VAL D 2 138 ? 19.858  10.257  71.767  1.00 40.37  ? 138 VAL L CG1 1 
ATOM   5918 C CG2 . VAL D 2 138 ? 18.169  12.099  71.896  1.00 42.19  ? 138 VAL L CG2 1 
ATOM   5919 N N   . CYS D 2 139 ? 18.676  7.807   73.363  1.00 35.91  ? 139 CYS L N   1 
ATOM   5920 C CA  . CYS D 2 139 ? 19.501  6.652   73.678  1.00 41.56  ? 139 CYS L CA  1 
ATOM   5921 C C   . CYS D 2 139 ? 20.493  6.402   72.536  1.00 36.04  ? 139 CYS L C   1 
ATOM   5922 O O   . CYS D 2 139 ? 20.179  6.661   71.384  1.00 39.02  ? 139 CYS L O   1 
ATOM   5923 C CB  . CYS D 2 139 ? 18.631  5.418   73.898  1.00 48.23  ? 139 CYS L CB  1 
ATOM   5924 S SG  . CYS D 2 139 ? 19.573  3.965   74.425  1.00 64.73  ? 139 CYS L SG  1 
ATOM   5925 N N   . LEU D 2 140 ? 21.678  5.876   72.870  1.00 35.58  ? 140 LEU L N   1 
ATOM   5926 C CA  . LEU D 2 140 ? 22.750  5.623   71.915  1.00 33.87  ? 140 LEU L CA  1 
ATOM   5927 C C   . LEU D 2 140 ? 23.242  4.197   72.093  1.00 32.73  ? 140 LEU L C   1 
ATOM   5928 O O   . LEU D 2 140 ? 23.534  3.794   73.207  1.00 35.97  ? 140 LEU L O   1 
ATOM   5929 C CB  . LEU D 2 140 ? 23.927  6.587   72.145  1.00 31.46  ? 140 LEU L CB  1 
ATOM   5930 C CG  . LEU D 2 140 ? 25.248  6.195   71.462  1.00 27.36  ? 140 LEU L CG  1 
ATOM   5931 C CD1 . LEU D 2 140 ? 25.119  6.202   69.947  1.00 24.66  ? 140 LEU L CD1 1 
ATOM   5932 C CD2 . LEU D 2 140 ? 26.396  7.121   71.886  1.00 28.81  ? 140 LEU L CD2 1 
ATOM   5933 N N   . LEU D 2 141 ? 23.330  3.458   70.985  1.00 35.50  ? 141 LEU L N   1 
ATOM   5934 C CA  . LEU D 2 141 ? 23.920  2.126   70.946  1.00 37.70  ? 141 LEU L CA  1 
ATOM   5935 C C   . LEU D 2 141 ? 25.190  2.201   70.098  1.00 35.40  ? 141 LEU L C   1 
ATOM   5936 O O   . LEU D 2 141 ? 25.097  2.432   68.892  1.00 33.74  ? 141 LEU L O   1 
ATOM   5937 C CB  . LEU D 2 141 ? 22.901  1.180   70.291  1.00 38.44  ? 141 LEU L CB  1 
ATOM   5938 C CG  . LEU D 2 141 ? 21.738  0.652   71.136  1.00 37.98  ? 141 LEU L CG  1 
ATOM   5939 C CD1 . LEU D 2 141 ? 20.898  1.758   71.749  1.00 42.57  ? 141 LEU L CD1 1 
ATOM   5940 C CD2 . LEU D 2 141 ? 20.848  -0.213  70.267  1.00 38.06  ? 141 LEU L CD2 1 
ATOM   5941 N N   . ASN D 2 142 ? 26.366  1.994   70.697  1.00 36.43  ? 142 ASN L N   1 
ATOM   5942 C CA  . ASN D 2 142 ? 27.595  2.440   70.060  1.00 34.60  ? 142 ASN L CA  1 
ATOM   5943 C C   . ASN D 2 142 ? 28.487  1.265   69.686  1.00 33.91  ? 142 ASN L C   1 
ATOM   5944 O O   . ASN D 2 142 ? 28.744  0.382   70.499  1.00 36.76  ? 142 ASN L O   1 
ATOM   5945 C CB  . ASN D 2 142 ? 28.344  3.458   70.919  1.00 35.88  ? 142 ASN L CB  1 
ATOM   5946 C CG  . ASN D 2 142 ? 29.337  4.264   70.113  1.00 34.73  ? 142 ASN L CG  1 
ATOM   5947 O OD1 . ASN D 2 142 ? 28.971  4.967   69.173  1.00 35.14  ? 142 ASN L OD1 1 
ATOM   5948 N ND2 . ASN D 2 142 ? 30.607  4.127   70.429  1.00 37.71  ? 142 ASN L ND2 1 
ATOM   5949 N N   . ASN D 2 143 ? 28.942  1.281   68.421  1.00 31.38  ? 143 ASN L N   1 
ATOM   5950 C CA  . ASN D 2 143 ? 29.957  0.375   67.897  1.00 30.67  ? 143 ASN L CA  1 
ATOM   5951 C C   . ASN D 2 143 ? 29.574  -1.083  68.126  1.00 30.74  ? 143 ASN L C   1 
ATOM   5952 O O   . ASN D 2 143 ? 30.278  -1.802  68.828  1.00 33.28  ? 143 ASN L O   1 
ATOM   5953 C CB  . ASN D 2 143 ? 31.354  0.676   68.441  1.00 30.28  ? 143 ASN L CB  1 
ATOM   5954 C CG  . ASN D 2 143 ? 31.857  2.033   67.991  1.00 33.36  ? 143 ASN L CG  1 
ATOM   5955 O OD1 . ASN D 2 143 ? 31.077  2.911   67.640  1.00 29.82  ? 143 ASN L OD1 1 
ATOM   5956 N ND2 . ASN D 2 143 ? 33.164  2.220   67.981  1.00 38.03  ? 143 ASN L ND2 1 
ATOM   5957 N N   . PHE D 2 144 ? 28.503  -1.537  67.454  1.00 31.86  ? 144 PHE L N   1 
ATOM   5958 C CA  . PHE D 2 144 ? 28.069  -2.918  67.594  1.00 32.10  ? 144 PHE L CA  1 
ATOM   5959 C C   . PHE D 2 144 ? 28.152  -3.675  66.269  1.00 32.80  ? 144 PHE L C   1 
ATOM   5960 O O   . PHE D 2 144 ? 28.029  -3.111  65.185  1.00 30.89  ? 144 PHE L O   1 
ATOM   5961 C CB  . PHE D 2 144 ? 26.678  -2.986  68.236  1.00 30.27  ? 144 PHE L CB  1 
ATOM   5962 C CG  . PHE D 2 144 ? 25.550  -2.297  67.523  1.00 27.46  ? 144 PHE L CG  1 
ATOM   5963 C CD1 . PHE D 2 144 ? 24.837  -2.952  66.536  1.00 27.88  ? 144 PHE L CD1 1 
ATOM   5964 C CD2 . PHE D 2 144 ? 25.177  -1.002  67.866  1.00 26.86  ? 144 PHE L CD2 1 
ATOM   5965 C CE1 . PHE D 2 144 ? 23.796  -2.310  65.881  1.00 27.82  ? 144 PHE L CE1 1 
ATOM   5966 C CE2 . PHE D 2 144 ? 24.126  -0.366  67.220  1.00 27.87  ? 144 PHE L CE2 1 
ATOM   5967 C CZ  . PHE D 2 144 ? 23.431  -1.023  66.228  1.00 28.03  ? 144 PHE L CZ  1 
ATOM   5968 N N   . TYR D 2 145 ? 28.389  -4.985  66.376  1.00 35.18  ? 145 TYR L N   1 
ATOM   5969 C CA  . TYR D 2 145 ? 28.250  -5.826  65.205  1.00 36.79  ? 145 TYR L CA  1 
ATOM   5970 C C   . TYR D 2 145 ? 27.544  -7.123  65.592  1.00 42.06  ? 145 TYR L C   1 
ATOM   5971 O O   . TYR D 2 145 ? 28.112  -7.890  66.367  1.00 37.56  ? 145 TYR L O   1 
ATOM   5972 C CB  . TYR D 2 145 ? 29.604  -6.102  64.557  1.00 33.07  ? 145 TYR L CB  1 
ATOM   5973 C CG  . TYR D 2 145 ? 29.471  -6.749  63.210  1.00 33.15  ? 145 TYR L CG  1 
ATOM   5974 C CD1 . TYR D 2 145 ? 29.144  -6.001  62.087  1.00 35.93  ? 145 TYR L CD1 1 
ATOM   5975 C CD2 . TYR D 2 145 ? 29.576  -8.124  63.070  1.00 36.40  ? 145 TYR L CD2 1 
ATOM   5976 C CE1 . TYR D 2 145 ? 28.962  -6.596  60.845  1.00 35.82  ? 145 TYR L CE1 1 
ATOM   5977 C CE2 . TYR D 2 145 ? 29.392  -8.738  61.841  1.00 38.63  ? 145 TYR L CE2 1 
ATOM   5978 C CZ  . TYR D 2 145 ? 29.086  -7.972  60.724  1.00 40.50  ? 145 TYR L CZ  1 
ATOM   5979 O OH  . TYR D 2 145 ? 28.914  -8.593  59.510  1.00 42.26  ? 145 TYR L OH  1 
ATOM   5980 N N   . PRO D 2 146 ? 26.395  -7.474  64.949  1.00 40.69  ? 146 PRO L N   1 
ATOM   5981 C CA  . PRO D 2 146 ? 25.940  -6.839  63.713  1.00 39.27  ? 146 PRO L CA  1 
ATOM   5982 C C   . PRO D 2 146 ? 24.753  -5.899  63.865  1.00 39.75  ? 146 PRO L C   1 
ATOM   5983 O O   . PRO D 2 146 ? 24.404  -5.505  64.975  1.00 55.38  ? 146 PRO L O   1 
ATOM   5984 C CB  . PRO D 2 146 ? 25.599  -8.098  62.904  1.00 41.89  ? 146 PRO L CB  1 
ATOM   5985 C CG  . PRO D 2 146 ? 24.889  -8.977  63.924  1.00 43.69  ? 146 PRO L CG  1 
ATOM   5986 C CD  . PRO D 2 146 ? 25.567  -8.653  65.248  1.00 44.57  ? 146 PRO L CD  1 
ATOM   5987 N N   . ARG D 2 147 ? 24.116  -5.575  62.740  1.00 37.51  ? 147 ARG L N   1 
ATOM   5988 C CA  . ARG D 2 147 ? 23.297  -4.382  62.626  1.00 41.18  ? 147 ARG L CA  1 
ATOM   5989 C C   . ARG D 2 147 ? 21.989  -4.497  63.413  1.00 43.86  ? 147 ARG L C   1 
ATOM   5990 O O   . ARG D 2 147 ? 21.295  -3.496  63.590  1.00 40.24  ? 147 ARG L O   1 
ATOM   5991 C CB  . ARG D 2 147 ? 23.000  -4.159  61.147  1.00 42.71  ? 147 ARG L CB  1 
ATOM   5992 C CG  . ARG D 2 147 ? 22.601  -2.736  60.794  1.00 47.83  ? 147 ARG L CG  1 
ATOM   5993 C CD  . ARG D 2 147 ? 22.258  -2.688  59.313  1.00 49.96  ? 147 ARG L CD  1 
ATOM   5994 N NE  . ARG D 2 147 ? 21.608  -1.454  58.899  1.00 52.81  ? 147 ARG L NE  1 
ATOM   5995 C CZ  . ARG D 2 147 ? 20.443  -1.008  59.360  1.00 56.38  ? 147 ARG L CZ  1 
ATOM   5996 N NH1 . ARG D 2 147 ? 19.833  -1.617  60.364  1.00 58.42  ? 147 ARG L NH1 1 
ATOM   5997 N NH2 . ARG D 2 147 ? 19.893  0.070   58.825  1.00 57.54  ? 147 ARG L NH2 1 
ATOM   5998 N N   . GLU D 2 148 ? 21.686  -5.700  63.924  1.00 52.22  ? 148 GLU L N   1 
ATOM   5999 C CA  . GLU D 2 148 ? 20.339  -6.060  64.341  1.00 56.68  ? 148 GLU L CA  1 
ATOM   6000 C C   . GLU D 2 148 ? 20.144  -5.663  65.797  1.00 53.56  ? 148 GLU L C   1 
ATOM   6001 O O   . GLU D 2 148 ? 20.740  -6.288  66.676  1.00 57.47  ? 148 GLU L O   1 
ATOM   6002 C CB  . GLU D 2 148 ? 20.105  -7.571  64.189  1.00 66.04  ? 148 GLU L CB  1 
ATOM   6003 C CG  . GLU D 2 148 ? 19.831  -8.050  62.760  1.00 67.62  ? 148 GLU L CG  1 
ATOM   6004 C CD  . GLU D 2 148 ? 21.026  -8.437  61.889  1.00 64.97  ? 148 GLU L CD  1 
ATOM   6005 O OE1 . GLU D 2 148 ? 21.811  -9.346  62.287  1.00 56.81  ? 148 GLU L OE1 1 
ATOM   6006 O OE2 . GLU D 2 148 ? 21.150  -7.854  60.789  1.00 54.26  ? 148 GLU L OE2 1 
ATOM   6007 N N   . ALA D 2 149 ? 19.286  -4.655  66.038  1.00 53.38  ? 149 ALA L N   1 
ATOM   6008 C CA  . ALA D 2 149 ? 19.115  -4.080  67.370  1.00 53.09  ? 149 ALA L CA  1 
ATOM   6009 C C   . ALA D 2 149 ? 17.694  -3.558  67.575  1.00 56.76  ? 149 ALA L C   1 
ATOM   6010 O O   . ALA D 2 149 ? 17.082  -3.058  66.631  1.00 48.90  ? 149 ALA L O   1 
ATOM   6011 C CB  . ALA D 2 149 ? 20.104  -2.953  67.581  1.00 50.84  ? 149 ALA L CB  1 
ATOM   6012 N N   . LYS D 2 150 ? 17.233  -3.609  68.841  1.00 57.94  ? 150 LYS L N   1 
ATOM   6013 C CA  . LYS D 2 150 ? 15.931  -3.099  69.235  1.00 57.94  ? 150 LYS L CA  1 
ATOM   6014 C C   . LYS D 2 150 ? 16.053  -2.194  70.462  1.00 50.22  ? 150 LYS L C   1 
ATOM   6015 O O   . LYS D 2 150 ? 16.735  -2.512  71.442  1.00 40.36  ? 150 LYS L O   1 
ATOM   6016 C CB  . LYS D 2 150 ? 14.968  -4.245  69.568  1.00 70.55  ? 150 LYS L CB  1 
ATOM   6017 C CG  . LYS D 2 150 ? 13.491  -3.863  69.661  1.00 80.75  ? 150 LYS L CG  1 
ATOM   6018 C CD  . LYS D 2 150 ? 12.642  -4.838  70.475  1.00 88.57  ? 150 LYS L CD  1 
ATOM   6019 C CE  . LYS D 2 150 ? 12.791  -6.286  70.050  1.00 96.03  ? 150 LYS L CE  1 
ATOM   6020 N NZ  . LYS D 2 150 ? 12.181  -7.217  71.029  1.00 96.95  ? 150 LYS L NZ  1 
ATOM   6021 N N   . VAL D 2 151 ? 15.297  -1.097  70.404  1.00 46.80  ? 151 VAL L N   1 
ATOM   6022 C CA  . VAL D 2 151 ? 15.223  -0.127  71.479  1.00 54.98  ? 151 VAL L CA  1 
ATOM   6023 C C   . VAL D 2 151 ? 13.770  -0.055  71.957  1.00 51.57  ? 151 VAL L C   1 
ATOM   6024 O O   . VAL D 2 151 ? 12.864  0.121   71.142  1.00 49.15  ? 151 VAL L O   1 
ATOM   6025 C CB  . VAL D 2 151 ? 15.742  1.247   70.997  1.00 61.09  ? 151 VAL L CB  1 
ATOM   6026 C CG1 . VAL D 2 151 ? 15.654  2.324   72.072  1.00 62.37  ? 151 VAL L CG1 1 
ATOM   6027 C CG2 . VAL D 2 151 ? 17.166  1.157   70.461  1.00 65.99  ? 151 VAL L CG2 1 
ATOM   6028 N N   . GLN D 2 152 ? 13.568  -0.167  73.281  1.00 54.23  ? 152 GLN L N   1 
ATOM   6029 C CA  . GLN D 2 152 ? 12.274  0.080   73.906  1.00 58.82  ? 152 GLN L CA  1 
ATOM   6030 C C   . GLN D 2 152 ? 12.390  1.140   75.006  1.00 51.94  ? 152 GLN L C   1 
ATOM   6031 O O   . GLN D 2 152 ? 13.138  0.979   75.970  1.00 37.66  ? 152 GLN L O   1 
ATOM   6032 C CB  . GLN D 2 152 ? 11.683  -1.216  74.463  1.00 66.75  ? 152 GLN L CB  1 
ATOM   6033 C CG  . GLN D 2 152 ? 11.066  -2.113  73.395  1.00 73.32  ? 152 GLN L CG  1 
ATOM   6034 C CD  . GLN D 2 152 ? 10.965  -3.556  73.835  1.00 83.74  ? 152 GLN L CD  1 
ATOM   6035 O OE1 . GLN D 2 152 ? 11.596  -3.978  74.803  1.00 86.91  ? 152 GLN L OE1 1 
ATOM   6036 N NE2 . GLN D 2 152 ? 10.185  -4.339  73.104  1.00 83.71  ? 152 GLN L NE2 1 
ATOM   6037 N N   . TRP D 2 153 ? 11.592  2.205   74.832  1.00 53.58  ? 153 TRP L N   1 
ATOM   6038 C CA  . TRP D 2 153 ? 11.366  3.248   75.821  1.00 61.90  ? 153 TRP L CA  1 
ATOM   6039 C C   . TRP D 2 153 ? 10.258  2.839   76.800  1.00 64.14  ? 153 TRP L C   1 
ATOM   6040 O O   . TRP D 2 153 ? 9.128   2.515   76.408  1.00 56.03  ? 153 TRP L O   1 
ATOM   6041 C CB  . TRP D 2 153 ? 11.009  4.585   75.138  1.00 65.57  ? 153 TRP L CB  1 
ATOM   6042 C CG  . TRP D 2 153 ? 12.120  5.211   74.348  1.00 71.72  ? 153 TRP L CG  1 
ATOM   6043 C CD1 . TRP D 2 153 ? 12.275  5.188   72.990  1.00 73.26  ? 153 TRP L CD1 1 
ATOM   6044 C CD2 . TRP D 2 153 ? 13.218  5.984   74.861  1.00 70.33  ? 153 TRP L CD2 1 
ATOM   6045 N NE1 . TRP D 2 153 ? 13.400  5.879   72.626  1.00 75.81  ? 153 TRP L NE1 1 
ATOM   6046 C CE2 . TRP D 2 153 ? 14.000  6.379   73.751  1.00 74.32  ? 153 TRP L CE2 1 
ATOM   6047 C CE3 . TRP D 2 153 ? 13.627  6.371   76.143  1.00 77.06  ? 153 TRP L CE3 1 
ATOM   6048 C CZ2 . TRP D 2 153 ? 15.159  7.144   73.890  1.00 67.44  ? 153 TRP L CZ2 1 
ATOM   6049 C CZ3 . TRP D 2 153 ? 14.774  7.128   76.281  1.00 76.08  ? 153 TRP L CZ3 1 
ATOM   6050 C CH2 . TRP D 2 153 ? 15.529  7.506   75.166  1.00 73.13  ? 153 TRP L CH2 1 
ATOM   6051 N N   . LYS D 2 154 ? 10.604  2.892   78.093  1.00 64.95  ? 154 LYS L N   1 
ATOM   6052 C CA  . LYS D 2 154 ? 9.634   2.832   79.170  1.00 56.04  ? 154 LYS L CA  1 
ATOM   6053 C C   . LYS D 2 154 ? 9.681   4.149   79.939  1.00 53.40  ? 154 LYS L C   1 
ATOM   6054 O O   . LYS D 2 154 ? 10.748  4.658   80.280  1.00 51.03  ? 154 LYS L O   1 
ATOM   6055 C CB  . LYS D 2 154 ? 9.877   1.620   80.073  1.00 57.14  ? 154 LYS L CB  1 
ATOM   6056 C CG  . LYS D 2 154 ? 11.239  1.576   80.751  1.00 63.46  ? 154 LYS L CG  1 
ATOM   6057 C CD  . LYS D 2 154 ? 11.579  0.232   81.352  1.00 69.11  ? 154 LYS L CD  1 
ATOM   6058 C CE  . LYS D 2 154 ? 11.785  -0.843  80.305  1.00 73.34  ? 154 LYS L CE  1 
ATOM   6059 N NZ  . LYS D 2 154 ? 11.812  -2.193  80.915  1.00 75.48  ? 154 LYS L NZ  1 
ATOM   6060 N N   . VAL D 2 155 ? 8.491   4.704   80.165  1.00 52.14  ? 155 VAL L N   1 
ATOM   6061 C CA  . VAL D 2 155 ? 8.294   5.866   81.012  1.00 58.19  ? 155 VAL L CA  1 
ATOM   6062 C C   . VAL D 2 155 ? 7.529   5.408   82.262  1.00 56.83  ? 155 VAL L C   1 
ATOM   6063 O O   . VAL D 2 155 ? 6.360   5.028   82.167  1.00 57.86  ? 155 VAL L O   1 
ATOM   6064 C CB  . VAL D 2 155 ? 7.552   6.964   80.217  1.00 62.27  ? 155 VAL L CB  1 
ATOM   6065 C CG1 . VAL D 2 155 ? 7.245   8.191   81.064  1.00 68.88  ? 155 VAL L CG1 1 
ATOM   6066 C CG2 . VAL D 2 155 ? 8.317   7.366   78.960  1.00 62.03  ? 155 VAL L CG2 1 
ATOM   6067 N N   . ASP D 2 156 ? 8.204   5.426   83.424  1.00 57.02  ? 156 ASP L N   1 
ATOM   6068 C CA  . ASP D 2 156 ? 7.696   4.852   84.668  1.00 57.48  ? 156 ASP L CA  1 
ATOM   6069 C C   . ASP D 2 156 ? 7.323   3.384   84.443  1.00 60.46  ? 156 ASP L C   1 
ATOM   6070 O O   . ASP D 2 156 ? 6.294   2.940   84.950  1.00 59.75  ? 156 ASP L O   1 
ATOM   6071 C CB  . ASP D 2 156 ? 6.471   5.596   85.232  1.00 55.18  ? 156 ASP L CB  1 
ATOM   6072 C CG  . ASP D 2 156 ? 6.695   7.048   85.626  1.00 53.16  ? 156 ASP L CG  1 
ATOM   6073 O OD1 . ASP D 2 156 ? 7.728   7.339   86.271  1.00 51.63  ? 156 ASP L OD1 1 
ATOM   6074 O OD2 . ASP D 2 156 ? 5.821   7.878   85.299  1.00 54.04  ? 156 ASP L OD2 1 
ATOM   6075 N N   . ASN D 2 157 ? 8.132   2.667   83.640  1.00 59.33  ? 157 ASN L N   1 
ATOM   6076 C CA  . ASN D 2 157 ? 8.007   1.231   83.411  1.00 55.51  ? 157 ASN L CA  1 
ATOM   6077 C C   . ASN D 2 157 ? 6.937   0.869   82.379  1.00 54.48  ? 157 ASN L C   1 
ATOM   6078 O O   . ASN D 2 157 ? 6.772   -0.316  82.106  1.00 54.96  ? 157 ASN L O   1 
ATOM   6079 C CB  . ASN D 2 157 ? 7.736   0.449   84.699  1.00 55.93  ? 157 ASN L CB  1 
ATOM   6080 C CG  . ASN D 2 157 ? 8.881   0.560   85.678  1.00 56.93  ? 157 ASN L CG  1 
ATOM   6081 O OD1 . ASN D 2 157 ? 9.876   -0.145  85.539  1.00 53.84  ? 157 ASN L OD1 1 
ATOM   6082 N ND2 . ASN D 2 157 ? 8.756   1.442   86.656  1.00 58.37  ? 157 ASN L ND2 1 
ATOM   6083 N N   . ALA D 2 158 ? 6.234   1.854   81.796  1.00 52.98  ? 158 ALA L N   1 
ATOM   6084 C CA  . ALA D 2 158 ? 5.322   1.612   80.680  1.00 50.78  ? 158 ALA L CA  1 
ATOM   6085 C C   . ALA D 2 158 ? 6.071   1.703   79.339  1.00 53.38  ? 158 ALA L C   1 
ATOM   6086 O O   . ALA D 2 158 ? 6.655   2.741   78.995  1.00 44.00  ? 158 ALA L O   1 
ATOM   6087 C CB  . ALA D 2 158 ? 4.162   2.586   80.734  1.00 44.25  ? 158 ALA L CB  1 
ATOM   6088 N N   . LEU D 2 159 ? 6.044   0.606   78.571  1.00 55.47  ? 159 LEU L N   1 
ATOM   6089 C CA  . LEU D 2 159 ? 6.592   0.601   77.224  1.00 59.31  ? 159 LEU L CA  1 
ATOM   6090 C C   . LEU D 2 159 ? 5.824   1.609   76.359  1.00 62.67  ? 159 LEU L C   1 
ATOM   6091 O O   . LEU D 2 159 ? 4.590   1.638   76.367  1.00 54.26  ? 159 LEU L O   1 
ATOM   6092 C CB  . LEU D 2 159 ? 6.507   -0.814  76.646  1.00 57.25  ? 159 LEU L CB  1 
ATOM   6093 C CG  . LEU D 2 159 ? 6.672   -0.895  75.127  1.00 59.30  ? 159 LEU L CG  1 
ATOM   6094 C CD1 . LEU D 2 159 ? 8.139   -0.738  74.728  1.00 58.23  ? 159 LEU L CD1 1 
ATOM   6095 C CD2 . LEU D 2 159 ? 6.082   -2.188  74.574  1.00 55.07  ? 159 LEU L CD2 1 
ATOM   6096 N N   . GLN D 2 160 ? 6.577   2.427   75.602  1.00 64.19  ? 160 GLN L N   1 
ATOM   6097 C CA  . GLN D 2 160 ? 6.014   3.491   74.777  1.00 58.02  ? 160 GLN L CA  1 
ATOM   6098 C C   . GLN D 2 160 ? 5.842   3.011   73.331  1.00 56.40  ? 160 GLN L C   1 
ATOM   6099 O O   . GLN D 2 160 ? 6.290   1.919   72.973  1.00 53.87  ? 160 GLN L O   1 
ATOM   6100 C CB  . GLN D 2 160 ? 6.904   4.733   74.866  1.00 56.06  ? 160 GLN L CB  1 
ATOM   6101 C CG  . GLN D 2 160 ? 7.160   5.201   76.294  1.00 56.48  ? 160 GLN L CG  1 
ATOM   6102 C CD  . GLN D 2 160 ? 5.942   5.817   76.942  1.00 57.77  ? 160 GLN L CD  1 
ATOM   6103 O OE1 . GLN D 2 160 ? 5.599   6.972   76.699  1.00 52.10  ? 160 GLN L OE1 1 
ATOM   6104 N NE2 . GLN D 2 160 ? 5.288   5.056   77.804  1.00 58.25  ? 160 GLN L NE2 1 
ATOM   6105 N N   . SER D 2 161 ? 5.161   3.836   72.517  1.00 59.36  ? 161 SER L N   1 
ATOM   6106 C CA  . SER D 2 161 ? 4.743   3.471   71.171  1.00 56.92  ? 161 SER L CA  1 
ATOM   6107 C C   . SER D 2 161 ? 4.379   4.720   70.364  1.00 54.31  ? 161 SER L C   1 
ATOM   6108 O O   . SER D 2 161 ? 3.647   5.602   70.831  1.00 46.45  ? 161 SER L O   1 
ATOM   6109 C CB  . SER D 2 161 ? 3.576   2.518   71.223  1.00 58.64  ? 161 SER L CB  1 
ATOM   6110 O OG  . SER D 2 161 ? 3.897   1.344   71.951  1.00 63.32  ? 161 SER L OG  1 
ATOM   6111 N N   . GLY D 2 162 ? 4.907   4.796   69.139  1.00 54.28  ? 162 GLY L N   1 
ATOM   6112 C CA  . GLY D 2 162 ? 4.522   5.836   68.196  1.00 56.99  ? 162 GLY L CA  1 
ATOM   6113 C C   . GLY D 2 162 ? 4.882   7.252   68.652  1.00 54.80  ? 162 GLY L C   1 
ATOM   6114 O O   . GLY D 2 162 ? 4.249   8.208   68.201  1.00 55.55  ? 162 GLY L O   1 
ATOM   6115 N N   . ASN D 2 163 ? 5.892   7.380   69.533  1.00 49.46  ? 163 ASN L N   1 
ATOM   6116 C CA  . ASN D 2 163 ? 6.426   8.682   69.925  1.00 46.70  ? 163 ASN L CA  1 
ATOM   6117 C C   . ASN D 2 163 ? 7.962   8.694   69.881  1.00 43.58  ? 163 ASN L C   1 
ATOM   6118 O O   . ASN D 2 163 ? 8.583   9.583   70.480  1.00 40.43  ? 163 ASN L O   1 
ATOM   6119 C CB  . ASN D 2 163 ? 5.898   9.123   71.295  1.00 41.28  ? 163 ASN L CB  1 
ATOM   6120 C CG  . ASN D 2 163 ? 6.088   8.105   72.401  1.00 46.18  ? 163 ASN L CG  1 
ATOM   6121 O OD1 . ASN D 2 163 ? 6.728   7.064   72.222  1.00 41.96  ? 163 ASN L OD1 1 
ATOM   6122 N ND2 . ASN D 2 163 ? 5.533   8.411   73.568  1.00 45.13  ? 163 ASN L ND2 1 
ATOM   6123 N N   . SER D 2 164 ? 8.561   7.712   69.182  1.00 38.28  ? 164 SER L N   1 
ATOM   6124 C CA  . SER D 2 164 ? 10.003  7.662   68.987  1.00 43.43  ? 164 SER L CA  1 
ATOM   6125 C C   . SER D 2 164 ? 10.365  7.529   67.499  1.00 45.95  ? 164 SER L C   1 
ATOM   6126 O O   . SER D 2 164 ? 9.565   7.078   66.679  1.00 39.72  ? 164 SER L O   1 
ATOM   6127 C CB  . SER D 2 164 ? 10.635  6.565   69.840  1.00 44.41  ? 164 SER L CB  1 
ATOM   6128 O OG  . SER D 2 164 ? 10.455  5.272   69.290  1.00 37.55  ? 164 SER L OG  1 
ATOM   6129 N N   . GLN D 2 165 ? 11.586  7.964   67.146  1.00 49.98  ? 165 GLN L N   1 
ATOM   6130 C CA  . GLN D 2 165 ? 12.137  7.795   65.803  1.00 45.47  ? 165 GLN L CA  1 
ATOM   6131 C C   . GLN D 2 165 ? 13.595  7.358   65.948  1.00 41.80  ? 165 GLN L C   1 
ATOM   6132 O O   . GLN D 2 165 ? 14.293  7.809   66.851  1.00 40.97  ? 165 GLN L O   1 
ATOM   6133 C CB  . GLN D 2 165 ? 12.004  9.084   64.978  1.00 42.37  ? 165 GLN L CB  1 
ATOM   6134 C CG  . GLN D 2 165 ? 10.586  9.662   64.931  1.00 45.97  ? 165 GLN L CG  1 
ATOM   6135 C CD  . GLN D 2 165 ? 10.430  10.879  64.040  1.00 44.93  ? 165 GLN L CD  1 
ATOM   6136 O OE1 . GLN D 2 165 ? 10.659  12.020  64.435  1.00 38.30  ? 165 GLN L OE1 1 
ATOM   6137 N NE2 . GLN D 2 165 ? 9.991   10.650  62.814  1.00 46.78  ? 165 GLN L NE2 1 
ATOM   6138 N N   . GLU D 2 166 ? 14.040  6.468   65.063  1.00 40.85  ? 166 GLU L N   1 
ATOM   6139 C CA  . GLU D 2 166 ? 15.357  5.855   65.138  1.00 38.03  ? 166 GLU L CA  1 
ATOM   6140 C C   . GLU D 2 166 ? 16.187  6.246   63.916  1.00 37.98  ? 166 GLU L C   1 
ATOM   6141 O O   . GLU D 2 166 ? 15.626  6.513   62.858  1.00 37.85  ? 166 GLU L O   1 
ATOM   6142 C CB  . GLU D 2 166 ? 15.274  4.329   65.097  1.00 36.90  ? 166 GLU L CB  1 
ATOM   6143 C CG  . GLU D 2 166 ? 15.261  3.641   66.438  1.00 42.47  ? 166 GLU L CG  1 
ATOM   6144 C CD  . GLU D 2 166 ? 15.394  2.131   66.280  1.00 44.63  ? 166 GLU L CD  1 
ATOM   6145 O OE1 . GLU D 2 166 ? 15.399  1.665   65.121  1.00 47.02  ? 166 GLU L OE1 1 
ATOM   6146 O OE2 . GLU D 2 166 ? 15.492  1.415   67.298  1.00 50.91  ? 166 GLU L OE2 1 
ATOM   6147 N N   . SER D 2 167 ? 17.517  6.128   64.054  1.00 35.21  ? 167 SER L N   1 
ATOM   6148 C CA  . SER D 2 167 ? 18.480  6.397   63.006  1.00 32.46  ? 167 SER L CA  1 
ATOM   6149 C C   . SER D 2 167 ? 19.582  5.352   63.119  1.00 30.26  ? 167 SER L C   1 
ATOM   6150 O O   . SER D 2 167 ? 19.854  4.877   64.215  1.00 35.24  ? 167 SER L O   1 
ATOM   6151 C CB  . SER D 2 167 ? 19.009  7.801   63.192  1.00 39.16  ? 167 SER L CB  1 
ATOM   6152 O OG  . SER D 2 167 ? 19.322  8.428   61.967  1.00 40.95  ? 167 SER L OG  1 
ATOM   6153 N N   . VAL D 2 168 ? 20.215  4.976   62.004  1.00 27.11  ? 168 VAL L N   1 
ATOM   6154 C CA  . VAL D 2 168 ? 21.322  4.029   62.057  1.00 29.69  ? 168 VAL L CA  1 
ATOM   6155 C C   . VAL D 2 168 ? 22.419  4.462   61.094  1.00 29.80  ? 168 VAL L C   1 
ATOM   6156 O O   . VAL D 2 168 ? 22.170  4.785   59.931  1.00 32.91  ? 168 VAL L O   1 
ATOM   6157 C CB  . VAL D 2 168 ? 20.899  2.583   61.742  1.00 35.10  ? 168 VAL L CB  1 
ATOM   6158 C CG1 . VAL D 2 168 ? 22.009  1.598   62.071  1.00 33.61  ? 168 VAL L CG1 1 
ATOM   6159 C CG2 . VAL D 2 168 ? 19.611  2.212   62.468  1.00 40.84  ? 168 VAL L CG2 1 
ATOM   6160 N N   . THR D 2 169 ? 23.656  4.391   61.582  1.00 27.63  ? 169 THR L N   1 
ATOM   6161 C CA  . THR D 2 169 ? 24.810  4.749   60.772  1.00 27.84  ? 169 THR L CA  1 
ATOM   6162 C C   . THR D 2 169 ? 25.099  3.633   59.775  1.00 26.34  ? 169 THR L C   1 
ATOM   6163 O O   . THR D 2 169 ? 24.703  2.491   59.966  1.00 25.42  ? 169 THR L O   1 
ATOM   6164 C CB  . THR D 2 169 ? 26.058  5.003   61.625  1.00 24.85  ? 169 THR L CB  1 
ATOM   6165 O OG1 . THR D 2 169 ? 26.456  3.757   62.192  1.00 25.02  ? 169 THR L OG1 1 
ATOM   6166 C CG2 . THR D 2 169 ? 25.815  5.979   62.749  1.00 26.18  ? 169 THR L CG2 1 
ATOM   6167 N N   . GLU D 2 170 ? 25.792  4.013   58.707  1.00 25.98  ? 170 GLU L N   1 
ATOM   6168 C CA  . GLU D 2 170 ? 26.439  3.075   57.816  1.00 28.23  ? 170 GLU L CA  1 
ATOM   6169 C C   . GLU D 2 170 ? 27.621  2.447   58.555  1.00 24.39  ? 170 GLU L C   1 
ATOM   6170 O O   . GLU D 2 170 ? 28.149  3.017   59.501  1.00 19.97  ? 170 GLU L O   1 
ATOM   6171 C CB  . GLU D 2 170 ? 26.911  3.812   56.550  1.00 30.95  ? 170 GLU L CB  1 
ATOM   6172 C CG  . GLU D 2 170 ? 25.781  4.254   55.623  1.00 35.60  ? 170 GLU L CG  1 
ATOM   6173 C CD  . GLU D 2 170 ? 24.898  3.110   55.125  1.00 45.18  ? 170 GLU L CD  1 
ATOM   6174 O OE1 . GLU D 2 170 ? 23.686  3.113   55.442  1.00 50.34  ? 170 GLU L OE1 1 
ATOM   6175 O OE2 . GLU D 2 170 ? 25.416  2.200   54.423  1.00 47.67  ? 170 GLU L OE2 1 
ATOM   6176 N N   . GLN D 2 171 ? 28.030  1.271   58.087  1.00 22.78  ? 171 GLN L N   1 
ATOM   6177 C CA  . GLN D 2 171 ? 29.195  0.570   58.598  1.00 26.91  ? 171 GLN L CA  1 
ATOM   6178 C C   . GLN D 2 171 ? 30.406  1.518   58.636  1.00 26.70  ? 171 GLN L C   1 
ATOM   6179 O O   . GLN D 2 171 ? 30.816  2.086   57.631  1.00 26.46  ? 171 GLN L O   1 
ATOM   6180 C CB  . GLN D 2 171 ? 29.429  -0.688  57.750  1.00 25.06  ? 171 GLN L CB  1 
ATOM   6181 C CG  . GLN D 2 171 ? 30.517  -1.585  58.292  1.00 26.17  ? 171 GLN L CG  1 
ATOM   6182 C CD  . GLN D 2 171 ? 30.560  -2.928  57.607  1.00 26.25  ? 171 GLN L CD  1 
ATOM   6183 O OE1 . GLN D 2 171 ? 30.762  -3.039  56.394  1.00 24.41  ? 171 GLN L OE1 1 
ATOM   6184 N NE2 . GLN D 2 171 ? 30.411  -3.973  58.411  1.00 25.81  ? 171 GLN L NE2 1 
ATOM   6185 N N   . ASP D 2 172 ? 30.980  1.663   59.828  1.00 24.57  ? 172 ASP L N   1 
ATOM   6186 C CA  . ASP D 2 172 ? 32.173  2.447   60.054  1.00 28.93  ? 172 ASP L CA  1 
ATOM   6187 C C   . ASP D 2 172 ? 33.326  1.942   59.179  1.00 32.51  ? 172 ASP L C   1 
ATOM   6188 O O   . ASP D 2 172 ? 33.663  0.753   59.190  1.00 29.52  ? 172 ASP L O   1 
ATOM   6189 C CB  . ASP D 2 172 ? 32.557  2.365   61.530  1.00 29.75  ? 172 ASP L CB  1 
ATOM   6190 C CG  . ASP D 2 172 ? 33.687  3.317   61.867  1.00 35.31  ? 172 ASP L CG  1 
ATOM   6191 O OD1 . ASP D 2 172 ? 33.395  4.507   62.103  1.00 38.63  ? 172 ASP L OD1 1 
ATOM   6192 O OD2 . ASP D 2 172 ? 34.861  2.868   61.827  1.00 37.71  ? 172 ASP L OD2 1 
ATOM   6193 N N   . SER D 2 173 ? 33.984  2.868   58.482  1.00 31.55  ? 173 SER L N   1 
ATOM   6194 C CA  . SER D 2 173 ? 35.063  2.501   57.570  1.00 38.13  ? 173 SER L CA  1 
ATOM   6195 C C   . SER D 2 173 ? 36.286  1.991   58.332  1.00 36.36  ? 173 SER L C   1 
ATOM   6196 O O   . SER D 2 173 ? 37.080  1.251   57.778  1.00 42.90  ? 173 SER L O   1 
ATOM   6197 C CB  . SER D 2 173 ? 35.420  3.630   56.620  1.00 37.40  ? 173 SER L CB  1 
ATOM   6198 O OG  . SER D 2 173 ? 35.747  4.807   57.339  1.00 43.21  ? 173 SER L OG  1 
ATOM   6199 N N   . LYS D 2 174 ? 36.407  2.302   59.619  1.00 37.42  ? 174 LYS L N   1 
ATOM   6200 C CA  . LYS D 2 174 ? 37.591  1.919   60.365  1.00 39.38  ? 174 LYS L CA  1 
ATOM   6201 C C   . LYS D 2 174 ? 37.421  0.549   61.039  1.00 36.67  ? 174 LYS L C   1 
ATOM   6202 O O   . LYS D 2 174 ? 38.274  -0.307  60.862  1.00 35.19  ? 174 LYS L O   1 
ATOM   6203 C CB  . LYS D 2 174 ? 37.916  3.042   61.347  1.00 48.55  ? 174 LYS L CB  1 
ATOM   6204 C CG  . LYS D 2 174 ? 39.272  2.928   62.027  1.00 64.73  ? 174 LYS L CG  1 
ATOM   6205 C CD  . LYS D 2 174 ? 39.740  4.231   62.668  1.00 71.68  ? 174 LYS L CD  1 
ATOM   6206 C CE  . LYS D 2 174 ? 40.741  4.018   63.786  1.00 76.04  ? 174 LYS L CE  1 
ATOM   6207 N NZ  . LYS D 2 174 ? 40.120  3.301   64.924  1.00 82.72  ? 174 LYS L NZ  1 
ATOM   6208 N N   . ASP D 2 175 ? 36.350  0.337   61.821  1.00 30.22  ? 175 ASP L N   1 
ATOM   6209 C CA  . ASP D 2 175 ? 36.215  -0.854  62.652  1.00 29.37  ? 175 ASP L CA  1 
ATOM   6210 C C   . ASP D 2 175 ? 35.042  -1.740  62.212  1.00 27.96  ? 175 ASP L C   1 
ATOM   6211 O O   . ASP D 2 175 ? 34.737  -2.740  62.857  1.00 28.73  ? 175 ASP L O   1 
ATOM   6212 C CB  . ASP D 2 175 ? 36.049  -0.444  64.122  1.00 29.63  ? 175 ASP L CB  1 
ATOM   6213 C CG  . ASP D 2 175 ? 34.761  0.306   64.422  1.00 30.25  ? 175 ASP L CG  1 
ATOM   6214 O OD1 . ASP D 2 175 ? 33.814  0.198   63.631  1.00 25.89  ? 175 ASP L OD1 1 
ATOM   6215 O OD2 . ASP D 2 175 ? 34.702  0.977   65.463  1.00 37.16  ? 175 ASP L OD2 1 
ATOM   6216 N N   . SER D 2 176 ? 34.324  -1.345  61.157  1.00 27.56  ? 176 SER L N   1 
ATOM   6217 C CA  . SER D 2 176 ? 33.288  -2.163  60.541  1.00 24.53  ? 176 SER L CA  1 
ATOM   6218 C C   . SER D 2 176 ? 32.104  -2.421  61.465  1.00 22.85  ? 176 SER L C   1 
ATOM   6219 O O   . SER D 2 176 ? 31.440  -3.437  61.296  1.00 24.65  ? 176 SER L O   1 
ATOM   6220 C CB  . SER D 2 176 ? 33.854  -3.469  60.015  1.00 24.64  ? 176 SER L CB  1 
ATOM   6221 O OG  . SER D 2 176 ? 34.821  -3.200  59.017  1.00 23.43  ? 176 SER L OG  1 
ATOM   6222 N N   . THR D 2 177 ? 31.816  -1.486  62.384  1.00 22.91  ? 177 THR L N   1 
ATOM   6223 C CA  . THR D 2 177 ? 30.717  -1.588  63.326  1.00 21.78  ? 177 THR L CA  1 
ATOM   6224 C C   . THR D 2 177 ? 29.607  -0.635  62.915  1.00 20.82  ? 177 THR L C   1 
ATOM   6225 O O   . THR D 2 177 ? 29.798  0.173   62.016  1.00 18.58  ? 177 THR L O   1 
ATOM   6226 C CB  . THR D 2 177 ? 31.138  -1.269  64.773  1.00 25.96  ? 177 THR L CB  1 
ATOM   6227 O OG1 . THR D 2 177 ? 31.553  0.099   64.874  1.00 28.15  ? 177 THR L OG1 1 
ATOM   6228 C CG2 . THR D 2 177 ? 32.241  -2.164  65.289  1.00 26.41  ? 177 THR L CG2 1 
ATOM   6229 N N   . TYR D 2 178 ? 28.481  -0.719  63.641  1.00 20.96  ? 178 TYR L N   1 
ATOM   6230 C CA  . TYR D 2 178 ? 27.315  0.129   63.460  1.00 22.25  ? 178 TYR L CA  1 
ATOM   6231 C C   . TYR D 2 178 ? 27.021  0.850   64.769  1.00 22.87  ? 178 TYR L C   1 
ATOM   6232 O O   . TYR D 2 178 ? 27.353  0.366   65.852  1.00 22.79  ? 178 TYR L O   1 
ATOM   6233 C CB  . TYR D 2 178 ? 26.076  -0.705  63.070  1.00 22.49  ? 178 TYR L CB  1 
ATOM   6234 C CG  . TYR D 2 178 ? 26.178  -1.420  61.742  1.00 21.09  ? 178 TYR L CG  1 
ATOM   6235 C CD1 . TYR D 2 178 ? 25.799  -0.816  60.554  1.00 22.67  ? 178 TYR L CD1 1 
ATOM   6236 C CD2 . TYR D 2 178 ? 26.718  -2.683  61.669  1.00 23.69  ? 178 TYR L CD2 1 
ATOM   6237 C CE1 . TYR D 2 178 ? 25.949  -1.457  59.330  1.00 24.74  ? 178 TYR L CE1 1 
ATOM   6238 C CE2 . TYR D 2 178 ? 26.882  -3.340  60.457  1.00 24.32  ? 178 TYR L CE2 1 
ATOM   6239 C CZ  . TYR D 2 178 ? 26.495  -2.731  59.285  1.00 24.53  ? 178 TYR L CZ  1 
ATOM   6240 O OH  . TYR D 2 178 ? 26.682  -3.421  58.119  1.00 25.53  ? 178 TYR L OH  1 
ATOM   6241 N N   . SER D 2 179 ? 26.303  1.959   64.661  1.00 22.90  ? 179 SER L N   1 
ATOM   6242 C CA  . SER D 2 179 ? 25.751  2.615   65.832  1.00 24.42  ? 179 SER L CA  1 
ATOM   6243 C C   . SER D 2 179 ? 24.304  2.985   65.536  1.00 25.76  ? 179 SER L C   1 
ATOM   6244 O O   . SER D 2 179 ? 23.919  3.040   64.365  1.00 24.33  ? 179 SER L O   1 
ATOM   6245 C CB  . SER D 2 179 ? 26.578  3.823   66.210  1.00 23.53  ? 179 SER L CB  1 
ATOM   6246 O OG  . SER D 2 179 ? 27.897  3.429   66.546  1.00 23.28  ? 179 SER L OG  1 
ATOM   6247 N N   . LEU D 2 180 ? 23.537  3.275   66.593  1.00 29.39  ? 180 LEU L N   1 
ATOM   6248 C CA  . LEU D 2 180 ? 22.120  3.585   66.459  1.00 33.20  ? 180 LEU L CA  1 
ATOM   6249 C C   . LEU D 2 180 ? 21.675  4.591   67.517  1.00 29.84  ? 180 LEU L C   1 
ATOM   6250 O O   . LEU D 2 180 ? 21.956  4.380   68.684  1.00 34.30  ? 180 LEU L O   1 
ATOM   6251 C CB  . LEU D 2 180 ? 21.358  2.257   66.574  1.00 35.82  ? 180 LEU L CB  1 
ATOM   6252 C CG  . LEU D 2 180 ? 19.836  2.328   66.450  1.00 42.62  ? 180 LEU L CG  1 
ATOM   6253 C CD1 . LEU D 2 180 ? 19.285  0.975   66.011  1.00 45.46  ? 180 LEU L CD1 1 
ATOM   6254 C CD2 . LEU D 2 180 ? 19.182  2.773   67.762  1.00 42.80  ? 180 LEU L CD2 1 
ATOM   6255 N N   . SER D 2 181 ? 20.931  5.635   67.111  1.00 31.73  ? 181 SER L N   1 
ATOM   6256 C CA  . SER D 2 181 ? 20.297  6.560   68.041  1.00 36.58  ? 181 SER L CA  1 
ATOM   6257 C C   . SER D 2 181 ? 18.777  6.521   67.904  1.00 39.91  ? 181 SER L C   1 
ATOM   6258 O O   . SER D 2 181 ? 18.256  6.379   66.806  1.00 37.05  ? 181 SER L O   1 
ATOM   6259 C CB  . SER D 2 181 ? 20.765  7.969   67.856  1.00 36.63  ? 181 SER L CB  1 
ATOM   6260 O OG  . SER D 2 181 ? 20.267  8.488   66.641  1.00 43.35  ? 181 SER L OG  1 
ATOM   6261 N N   . SER D 2 182 ? 18.092  6.706   69.040  1.00 43.47  ? 182 SER L N   1 
ATOM   6262 C CA  . SER D 2 182 ? 16.642  6.793   69.099  1.00 45.37  ? 182 SER L CA  1 
ATOM   6263 C C   . SER D 2 182 ? 16.218  8.021   69.901  1.00 41.76  ? 182 SER L C   1 
ATOM   6264 O O   . SER D 2 182 ? 16.818  8.342   70.918  1.00 45.29  ? 182 SER L O   1 
ATOM   6265 C CB  . SER D 2 182 ? 16.058  5.539   69.683  1.00 48.51  ? 182 SER L CB  1 
ATOM   6266 O OG  . SER D 2 182 ? 14.661  5.491   69.424  1.00 57.20  ? 182 SER L OG  1 
ATOM   6267 N N   . THR D 2 183 ? 15.155  8.678   69.442  1.00 42.00  ? 183 THR L N   1 
ATOM   6268 C CA  . THR D 2 183 ? 14.655  9.909   70.033  1.00 43.14  ? 183 THR L CA  1 
ATOM   6269 C C   . THR D 2 183 ? 13.188  9.711   70.426  1.00 41.80  ? 183 THR L C   1 
ATOM   6270 O O   . THR D 2 183 ? 12.333  9.464   69.571  1.00 39.19  ? 183 THR L O   1 
ATOM   6271 C CB  . THR D 2 183 ? 14.851  11.080  69.055  1.00 44.88  ? 183 THR L CB  1 
ATOM   6272 O OG1 . THR D 2 183 ? 16.254  11.224  68.854  1.00 44.06  ? 183 THR L OG1 1 
ATOM   6273 C CG2 . THR D 2 183 ? 14.276  12.402  69.523  1.00 49.66  ? 183 THR L CG2 1 
ATOM   6274 N N   . LEU D 2 184 ? 12.916  9.807   71.734  1.00 43.79  ? 184 LEU L N   1 
ATOM   6275 C CA  . LEU D 2 184 ? 11.560  9.829   72.269  1.00 42.99  ? 184 LEU L CA  1 
ATOM   6276 C C   . LEU D 2 184 ? 11.157  11.285  72.472  1.00 40.90  ? 184 LEU L C   1 
ATOM   6277 O O   . LEU D 2 184 ? 11.799  12.007  73.236  1.00 47.28  ? 184 LEU L O   1 
ATOM   6278 C CB  . LEU D 2 184 ? 11.534  9.045   73.587  1.00 42.54  ? 184 LEU L CB  1 
ATOM   6279 C CG  . LEU D 2 184 ? 10.340  9.298   74.513  1.00 46.73  ? 184 LEU L CG  1 
ATOM   6280 C CD1 . LEU D 2 184 ? 9.064   8.654   73.979  1.00 49.89  ? 184 LEU L CD1 1 
ATOM   6281 C CD2 . LEU D 2 184 ? 10.642  8.787   75.915  1.00 45.15  ? 184 LEU L CD2 1 
ATOM   6282 N N   . THR D 2 185 ? 10.101  11.719  71.788  1.00 40.84  ? 185 THR L N   1 
ATOM   6283 C CA  . THR D 2 185 ? 9.700   13.117  71.851  1.00 47.63  ? 185 THR L CA  1 
ATOM   6284 C C   . THR D 2 185 ? 8.378   13.206  72.619  1.00 49.50  ? 185 THR L C   1 
ATOM   6285 O O   . THR D 2 185 ? 7.382   12.630  72.183  1.00 53.54  ? 185 THR L O   1 
ATOM   6286 C CB  . THR D 2 185 ? 9.690   13.742  70.441  1.00 49.35  ? 185 THR L CB  1 
ATOM   6287 O OG1 . THR D 2 185 ? 11.002  13.678  69.871  1.00 50.55  ? 185 THR L OG1 1 
ATOM   6288 C CG2 . THR D 2 185 ? 9.252   15.191  70.423  1.00 51.18  ? 185 THR L CG2 1 
ATOM   6289 N N   . LEU D 2 186 ? 8.412   13.880  73.786  1.00 53.19  ? 186 LEU L N   1 
ATOM   6290 C CA  . LEU D 2 186 ? 7.227   14.241  74.563  1.00 52.29  ? 186 LEU L CA  1 
ATOM   6291 C C   . LEU D 2 186 ? 7.118   15.766  74.608  1.00 57.12  ? 186 LEU L C   1 
ATOM   6292 O O   . LEU D 2 186 ? 8.123   16.470  74.454  1.00 54.34  ? 186 LEU L O   1 
ATOM   6293 C CB  . LEU D 2 186 ? 7.341   13.690  75.995  1.00 50.95  ? 186 LEU L CB  1 
ATOM   6294 C CG  . LEU D 2 186 ? 7.751   12.222  76.152  1.00 52.22  ? 186 LEU L CG  1 
ATOM   6295 C CD1 . LEU D 2 186 ? 7.684   11.787  77.606  1.00 49.03  ? 186 LEU L CD1 1 
ATOM   6296 C CD2 . LEU D 2 186 ? 6.888   11.304  75.312  1.00 54.14  ? 186 LEU L CD2 1 
ATOM   6297 N N   . SER D 2 187 ? 5.908   16.288  74.860  1.00 56.71  ? 187 SER L N   1 
ATOM   6298 C CA  . SER D 2 187 ? 5.795   17.693  75.230  1.00 58.55  ? 187 SER L CA  1 
ATOM   6299 C C   . SER D 2 187 ? 6.316   17.851  76.659  1.00 52.24  ? 187 SER L C   1 
ATOM   6300 O O   . SER D 2 187 ? 6.420   16.868  77.395  1.00 44.81  ? 187 SER L O   1 
ATOM   6301 C CB  . SER D 2 187 ? 4.382   18.261  75.036  1.00 60.45  ? 187 SER L CB  1 
ATOM   6302 O OG  . SER D 2 187 ? 3.464   17.810  76.026  1.00 51.80  ? 187 SER L OG  1 
ATOM   6303 N N   . LYS D 2 188 ? 6.713   19.079  77.019  1.00 56.26  ? 188 LYS L N   1 
ATOM   6304 C CA  . LYS D 2 188 ? 7.195   19.357  78.363  1.00 62.52  ? 188 LYS L CA  1 
ATOM   6305 C C   . LYS D 2 188 ? 6.153   18.896  79.385  1.00 67.27  ? 188 LYS L C   1 
ATOM   6306 O O   . LYS D 2 188 ? 6.489   18.156  80.309  1.00 60.02  ? 188 LYS L O   1 
ATOM   6307 C CB  . LYS D 2 188 ? 7.499   20.846  78.551  1.00 67.00  ? 188 LYS L CB  1 
ATOM   6308 C CG  . LYS D 2 188 ? 8.250   21.183  79.831  1.00 71.30  ? 188 LYS L CG  1 
ATOM   6309 C CD  . LYS D 2 188 ? 8.059   22.606  80.301  1.00 77.17  ? 188 LYS L CD  1 
ATOM   6310 C CE  . LYS D 2 188 ? 8.647   22.829  81.677  1.00 80.41  ? 188 LYS L CE  1 
ATOM   6311 N NZ  . LYS D 2 188 ? 8.021   23.983  82.360  1.00 82.69  ? 188 LYS L NZ  1 
ATOM   6312 N N   . ALA D 2 189 ? 4.892   19.330  79.191  1.00 73.88  ? 189 ALA L N   1 
ATOM   6313 C CA  . ALA D 2 189 ? 3.775   18.971  80.060  1.00 70.15  ? 189 ALA L CA  1 
ATOM   6314 C C   . ALA D 2 189 ? 3.729   17.453  80.259  1.00 66.82  ? 189 ALA L C   1 
ATOM   6315 O O   . ALA D 2 189 ? 3.715   16.983  81.400  1.00 58.30  ? 189 ALA L O   1 
ATOM   6316 C CB  . ALA D 2 189 ? 2.477   19.508  79.488  1.00 65.93  ? 189 ALA L CB  1 
ATOM   6317 N N   . ASP D 2 190 ? 3.738   16.703  79.140  1.00 61.63  ? 190 ASP L N   1 
ATOM   6318 C CA  . ASP D 2 190 ? 3.809   15.246  79.168  1.00 61.15  ? 190 ASP L CA  1 
ATOM   6319 C C   . ASP D 2 190 ? 5.020   14.792  79.981  1.00 60.94  ? 190 ASP L C   1 
ATOM   6320 O O   . ASP D 2 190 ? 4.885   13.914  80.828  1.00 63.40  ? 190 ASP L O   1 
ATOM   6321 C CB  . ASP D 2 190 ? 3.856   14.624  77.764  1.00 59.23  ? 190 ASP L CB  1 
ATOM   6322 C CG  . ASP D 2 190 ? 2.549   14.002  77.277  1.00 59.82  ? 190 ASP L CG  1 
ATOM   6323 O OD1 . ASP D 2 190 ? 1.513   14.692  77.273  1.00 49.59  ? 190 ASP L OD1 1 
ATOM   6324 O OD2 . ASP D 2 190 ? 2.585   12.826  76.870  1.00 64.58  ? 190 ASP L OD2 1 
ATOM   6325 N N   . TYR D 2 191 ? 6.191   15.385  79.706  1.00 57.90  ? 191 TYR L N   1 
ATOM   6326 C CA  . TYR D 2 191 ? 7.449   14.934  80.286  1.00 56.91  ? 191 TYR L CA  1 
ATOM   6327 C C   . TYR D 2 191 ? 7.426   15.080  81.813  1.00 56.91  ? 191 TYR L C   1 
ATOM   6328 O O   . TYR D 2 191 ? 7.948   14.220  82.537  1.00 43.58  ? 191 TYR L O   1 
ATOM   6329 C CB  . TYR D 2 191 ? 8.619   15.696  79.648  1.00 52.95  ? 191 TYR L CB  1 
ATOM   6330 C CG  . TYR D 2 191 ? 9.983   15.402  80.234  1.00 52.06  ? 191 TYR L CG  1 
ATOM   6331 C CD1 . TYR D 2 191 ? 10.574  14.151  80.114  1.00 50.29  ? 191 TYR L CD1 1 
ATOM   6332 C CD2 . TYR D 2 191 ? 10.701  16.381  80.912  1.00 50.28  ? 191 TYR L CD2 1 
ATOM   6333 C CE1 . TYR D 2 191 ? 11.828  13.887  80.652  1.00 47.22  ? 191 TYR L CE1 1 
ATOM   6334 C CE2 . TYR D 2 191 ? 11.959  16.134  81.444  1.00 45.70  ? 191 TYR L CE2 1 
ATOM   6335 C CZ  . TYR D 2 191 ? 12.524  14.883  81.311  1.00 41.54  ? 191 TYR L CZ  1 
ATOM   6336 O OH  . TYR D 2 191 ? 13.747  14.634  81.868  1.00 42.08  ? 191 TYR L OH  1 
ATOM   6337 N N   . GLU D 2 192 ? 6.817   16.177  82.290  1.00 61.98  ? 192 GLU L N   1 
ATOM   6338 C CA  . GLU D 2 192 ? 6.831   16.544  83.703  1.00 72.10  ? 192 GLU L CA  1 
ATOM   6339 C C   . GLU D 2 192 ? 5.877   15.666  84.521  1.00 70.40  ? 192 GLU L C   1 
ATOM   6340 O O   . GLU D 2 192 ? 5.919   15.717  85.744  1.00 58.53  ? 192 GLU L O   1 
ATOM   6341 C CB  . GLU D 2 192 ? 6.446   18.017  83.888  1.00 78.15  ? 192 GLU L CB  1 
ATOM   6342 C CG  . GLU D 2 192 ? 7.388   19.009  83.213  1.00 84.72  ? 192 GLU L CG  1 
ATOM   6343 C CD  . GLU D 2 192 ? 8.550   19.513  84.054  1.00 88.82  ? 192 GLU L CD  1 
ATOM   6344 O OE1 . GLU D 2 192 ? 8.766   20.741  84.084  1.00 87.47  ? 192 GLU L OE1 1 
ATOM   6345 O OE2 . GLU D 2 192 ? 9.236   18.680  84.679  1.00 93.70  ? 192 GLU L OE2 1 
ATOM   6346 N N   . LYS D 2 193 ? 5.017   14.879  83.852  1.00 75.31  ? 193 LYS L N   1 
ATOM   6347 C CA  . LYS D 2 193 ? 4.092   13.965  84.513  1.00 73.89  ? 193 LYS L CA  1 
ATOM   6348 C C   . LYS D 2 193 ? 4.791   12.702  85.027  1.00 70.27  ? 193 LYS L C   1 
ATOM   6349 O O   . LYS D 2 193 ? 4.223   11.982  85.843  1.00 64.92  ? 193 LYS L O   1 
ATOM   6350 C CB  . LYS D 2 193 ? 2.987   13.501  83.553  1.00 74.56  ? 193 LYS L CB  1 
ATOM   6351 C CG  . LYS D 2 193 ? 1.728   14.356  83.487  1.00 78.29  ? 193 LYS L CG  1 
ATOM   6352 C CD  . LYS D 2 193 ? 0.549   13.612  82.863  1.00 80.49  ? 193 LYS L CD  1 
ATOM   6353 C CE  . LYS D 2 193 ? -0.804  14.188  83.232  1.00 80.14  ? 193 LYS L CE  1 
ATOM   6354 N NZ  . LYS D 2 193 ? -1.046  15.509  82.602  1.00 77.08  ? 193 LYS L NZ  1 
ATOM   6355 N N   . HIS D 2 194 ? 5.985   12.390  84.511  1.00 68.77  ? 194 HIS L N   1 
ATOM   6356 C CA  . HIS D 2 194 ? 6.558   11.065  84.686  1.00 69.05  ? 194 HIS L CA  1 
ATOM   6357 C C   . HIS D 2 194 ? 7.946   11.206  85.304  1.00 66.05  ? 194 HIS L C   1 
ATOM   6358 O O   . HIS D 2 194 ? 8.527   12.285  85.249  1.00 68.34  ? 194 HIS L O   1 
ATOM   6359 C CB  . HIS D 2 194 ? 6.549   10.325  83.345  1.00 69.53  ? 194 HIS L CB  1 
ATOM   6360 C CG  . HIS D 2 194 ? 5.221   10.306  82.644  1.00 75.32  ? 194 HIS L CG  1 
ATOM   6361 N ND1 . HIS D 2 194 ? 4.968   11.056  81.512  1.00 77.14  ? 194 HIS L ND1 1 
ATOM   6362 C CD2 . HIS D 2 194 ? 4.081   9.637   82.899  1.00 72.47  ? 194 HIS L CD2 1 
ATOM   6363 C CE1 . HIS D 2 194 ? 3.721   10.841  81.105  1.00 73.05  ? 194 HIS L CE1 1 
ATOM   6364 N NE2 . HIS D 2 194 ? 3.165   9.984   81.934  1.00 68.42  ? 194 HIS L NE2 1 
ATOM   6365 N N   . LYS D 2 195 ? 8.482   10.111  85.861  1.00 63.50  ? 195 LYS L N   1 
ATOM   6366 C CA  . LYS D 2 195 ? 9.627   10.200  86.754  1.00 66.43  ? 195 LYS L CA  1 
ATOM   6367 C C   . LYS D 2 195 ? 10.826  9.425   86.211  1.00 61.75  ? 195 LYS L C   1 
ATOM   6368 O O   . LYS D 2 195 ? 11.883  10.016  85.982  1.00 59.04  ? 195 LYS L O   1 
ATOM   6369 C CB  . LYS D 2 195 ? 9.253   9.703   88.154  1.00 75.58  ? 195 LYS L CB  1 
ATOM   6370 C CG  . LYS D 2 195 ? 10.222  10.117  89.251  1.00 79.60  ? 195 LYS L CG  1 
ATOM   6371 C CD  . LYS D 2 195 ? 10.185  11.605  89.553  1.00 87.38  ? 195 LYS L CD  1 
ATOM   6372 C CE  . LYS D 2 195 ? 11.284  12.054  90.493  1.00 92.19  ? 195 LYS L CE  1 
ATOM   6373 N NZ  . LYS D 2 195 ? 11.296  11.272  91.754  1.00 96.20  ? 195 LYS L NZ  1 
ATOM   6374 N N   . LEU D 2 196 ? 10.676  8.104   86.042  1.00 58.54  ? 196 LEU L N   1 
ATOM   6375 C CA  . LEU D 2 196 ? 11.745  7.275   85.496  1.00 56.98  ? 196 LEU L CA  1 
ATOM   6376 C C   . LEU D 2 196 ? 11.679  7.251   83.962  1.00 53.92  ? 196 LEU L C   1 
ATOM   6377 O O   . LEU D 2 196 ? 10.637  6.960   83.375  1.00 56.68  ? 196 LEU L O   1 
ATOM   6378 C CB  . LEU D 2 196 ? 11.640  5.861   86.082  1.00 51.65  ? 196 LEU L CB  1 
ATOM   6379 C CG  . LEU D 2 196 ? 12.456  4.783   85.361  1.00 54.72  ? 196 LEU L CG  1 
ATOM   6380 C CD1 . LEU D 2 196 ? 13.857  4.675   85.951  1.00 54.53  ? 196 LEU L CD1 1 
ATOM   6381 C CD2 . LEU D 2 196 ? 11.747  3.434   85.402  1.00 55.33  ? 196 LEU L CD2 1 
ATOM   6382 N N   . TYR D 2 197 ? 12.816  7.517   83.311  1.00 47.50  ? 197 TYR L N   1 
ATOM   6383 C CA  . TYR D 2 197 ? 12.939  7.319   81.873  1.00 46.84  ? 197 TYR L CA  1 
ATOM   6384 C C   . TYR D 2 197 ? 14.042  6.297   81.630  1.00 46.30  ? 197 TYR L C   1 
ATOM   6385 O O   . TYR D 2 197 ? 15.094  6.400   82.249  1.00 48.76  ? 197 TYR L O   1 
ATOM   6386 C CB  . TYR D 2 197 ? 13.196  8.670   81.205  1.00 47.41  ? 197 TYR L CB  1 
ATOM   6387 C CG  . TYR D 2 197 ? 12.041  9.632   81.298  1.00 47.42  ? 197 TYR L CG  1 
ATOM   6388 C CD1 . TYR D 2 197 ? 10.997  9.562   80.393  1.00 48.31  ? 197 TYR L CD1 1 
ATOM   6389 C CD2 . TYR D 2 197 ? 11.957  10.575  82.311  1.00 46.58  ? 197 TYR L CD2 1 
ATOM   6390 C CE1 . TYR D 2 197 ? 9.915   10.424  80.467  1.00 46.72  ? 197 TYR L CE1 1 
ATOM   6391 C CE2 . TYR D 2 197 ? 10.872  11.433  82.410  1.00 47.38  ? 197 TYR L CE2 1 
ATOM   6392 C CZ  . TYR D 2 197 ? 9.844   11.356  81.485  1.00 45.16  ? 197 TYR L CZ  1 
ATOM   6393 O OH  . TYR D 2 197 ? 8.760   12.207  81.520  1.00 39.91  ? 197 TYR L OH  1 
ATOM   6394 N N   . ALA D 2 198 ? 13.793  5.328   80.730  1.00 52.75  ? 198 ALA L N   1 
ATOM   6395 C CA  . ALA D 2 198 ? 14.677  4.178   80.531  1.00 57.07  ? 198 ALA L CA  1 
ATOM   6396 C C   . ALA D 2 198 ? 14.782  3.738   79.059  1.00 52.74  ? 198 ALA L C   1 
ATOM   6397 O O   . ALA D 2 198 ? 13.835  3.804   78.281  1.00 50.97  ? 198 ALA L O   1 
ATOM   6398 C CB  . ALA D 2 198 ? 14.205  3.035   81.402  1.00 56.30  ? 198 ALA L CB  1 
ATOM   6399 N N   . CYS D 2 199 ? 15.969  3.241   78.698  1.00 59.73  ? 199 CYS L N   1 
ATOM   6400 C CA  . CYS D 2 199 ? 16.273  2.755   77.362  1.00 62.98  ? 199 CYS L CA  1 
ATOM   6401 C C   . CYS D 2 199 ? 16.653  1.275   77.472  1.00 54.66  ? 199 CYS L C   1 
ATOM   6402 O O   . CYS D 2 199 ? 17.651  0.951   78.117  1.00 47.93  ? 199 CYS L O   1 
ATOM   6403 C CB  . CYS D 2 199 ? 17.399  3.580   76.729  1.00 61.52  ? 199 CYS L CB  1 
ATOM   6404 S SG  . CYS D 2 199 ? 18.293  2.694   75.421  1.00 89.51  ? 199 CYS L SG  1 
ATOM   6405 N N   . GLU D 2 200 ? 15.853  0.405   76.825  1.00 53.22  ? 200 GLU L N   1 
ATOM   6406 C CA  . GLU D 2 200 ? 16.011  -1.045  76.884  1.00 55.13  ? 200 GLU L CA  1 
ATOM   6407 C C   . GLU D 2 200 ? 16.504  -1.618  75.547  1.00 44.68  ? 200 GLU L C   1 
ATOM   6408 O O   . GLU D 2 200 ? 15.858  -1.431  74.525  1.00 40.54  ? 200 GLU L O   1 
ATOM   6409 C CB  . GLU D 2 200 ? 14.674  -1.695  77.242  1.00 59.65  ? 200 GLU L CB  1 
ATOM   6410 C CG  . GLU D 2 200 ? 14.841  -3.127  77.715  1.00 70.50  ? 200 GLU L CG  1 
ATOM   6411 C CD  . GLU D 2 200 ? 13.588  -3.984  77.678  1.00 75.12  ? 200 GLU L CD  1 
ATOM   6412 O OE1 . GLU D 2 200 ? 13.239  -4.490  76.586  1.00 71.56  ? 200 GLU L OE1 1 
ATOM   6413 O OE2 . GLU D 2 200 ? 12.972  -4.138  78.743  1.00 72.38  ? 200 GLU L OE2 1 
ATOM   6414 N N   . VAL D 2 201 ? 17.580  -2.421  75.575  1.00 41.90  ? 201 VAL L N   1 
ATOM   6415 C CA  . VAL D 2 201 ? 18.343  -2.716  74.369  1.00 45.83  ? 201 VAL L CA  1 
ATOM   6416 C C   . VAL D 2 201 ? 18.584  -4.211  74.182  1.00 45.03  ? 201 VAL L C   1 
ATOM   6417 O O   . VAL D 2 201 ? 19.324  -4.817  74.962  1.00 48.43  ? 201 VAL L O   1 
ATOM   6418 C CB  . VAL D 2 201 ? 19.694  -1.967  74.373  1.00 43.74  ? 201 VAL L CB  1 
ATOM   6419 C CG1 . VAL D 2 201 ? 20.638  -2.480  73.297  1.00 37.86  ? 201 VAL L CG1 1 
ATOM   6420 C CG2 . VAL D 2 201 ? 19.479  -0.468  74.242  1.00 42.58  ? 201 VAL L CG2 1 
ATOM   6421 N N   . THR D 2 202 ? 18.105  -4.707  73.024  1.00 43.18  ? 202 THR L N   1 
ATOM   6422 C CA  . THR D 2 202 ? 18.263  -6.075  72.561  1.00 41.33  ? 202 THR L CA  1 
ATOM   6423 C C   . THR D 2 202 ? 19.261  -6.157  71.411  1.00 38.75  ? 202 THR L C   1 
ATOM   6424 O O   . THR D 2 202 ? 19.005  -5.599  70.345  1.00 36.31  ? 202 THR L O   1 
ATOM   6425 C CB  . THR D 2 202 ? 16.932  -6.614  72.014  1.00 42.62  ? 202 THR L CB  1 
ATOM   6426 O OG1 . THR D 2 202 ? 16.035  -6.611  73.119  1.00 42.25  ? 202 THR L OG1 1 
ATOM   6427 C CG2 . THR D 2 202 ? 17.040  -7.991  71.393  1.00 42.52  ? 202 THR L CG2 1 
ATOM   6428 N N   . HIS D 2 203 ? 20.341  -6.929  71.615  1.00 35.76  ? 203 HIS L N   1 
ATOM   6429 C CA  . HIS D 2 203 ? 21.273  -7.240  70.550  1.00 36.61  ? 203 HIS L CA  1 
ATOM   6430 C C   . HIS D 2 203 ? 21.972  -8.558  70.863  1.00 41.55  ? 203 HIS L C   1 
ATOM   6431 O O   . HIS D 2 203 ? 22.286  -8.832  72.023  1.00 40.02  ? 203 HIS L O   1 
ATOM   6432 C CB  . HIS D 2 203 ? 22.318  -6.118  70.353  1.00 37.77  ? 203 HIS L CB  1 
ATOM   6433 C CG  . HIS D 2 203 ? 23.511  -6.474  69.481  1.00 32.12  ? 203 HIS L CG  1 
ATOM   6434 N ND1 . HIS D 2 203 ? 24.629  -7.127  69.960  1.00 31.70  ? 203 HIS L ND1 1 
ATOM   6435 C CD2 . HIS D 2 203 ? 23.749  -6.268  68.167  1.00 29.55  ? 203 HIS L CD2 1 
ATOM   6436 C CE1 . HIS D 2 203 ? 25.496  -7.318  68.962  1.00 33.28  ? 203 HIS L CE1 1 
ATOM   6437 N NE2 . HIS D 2 203 ? 24.971  -6.804  67.866  1.00 32.64  ? 203 HIS L NE2 1 
ATOM   6438 N N   . GLN D 2 204 ? 22.352  -9.234  69.763  1.00 45.06  ? 204 GLN L N   1 
ATOM   6439 C CA  . GLN D 2 204 ? 22.892  -10.588 69.684  1.00 45.14  ? 204 GLN L CA  1 
ATOM   6440 C C   . GLN D 2 204 ? 24.097  -10.827 70.604  1.00 37.74  ? 204 GLN L C   1 
ATOM   6441 O O   . GLN D 2 204 ? 24.451  -11.974 70.877  1.00 43.73  ? 204 GLN L O   1 
ATOM   6442 C CB  . GLN D 2 204 ? 23.263  -10.816 68.213  1.00 43.32  ? 204 GLN L CB  1 
ATOM   6443 C CG  . GLN D 2 204 ? 23.674  -12.241 67.851  1.00 49.56  ? 204 GLN L CG  1 
ATOM   6444 C CD  . GLN D 2 204 ? 24.343  -12.349 66.494  1.00 46.71  ? 204 GLN L CD  1 
ATOM   6445 O OE1 . GLN D 2 204 ? 23.735  -12.084 65.450  1.00 49.41  ? 204 GLN L OE1 1 
ATOM   6446 N NE2 . GLN D 2 204 ? 25.615  -12.722 66.508  1.00 43.06  ? 204 GLN L NE2 1 
ATOM   6447 N N   . GLY D 2 205 ? 24.773  -9.774  71.046  1.00 34.96  ? 205 GLY L N   1 
ATOM   6448 C CA  . GLY D 2 205 ? 26.038  -9.938  71.744  1.00 38.03  ? 205 GLY L CA  1 
ATOM   6449 C C   . GLY D 2 205 ? 25.872  -9.618  73.223  1.00 41.37  ? 205 GLY L C   1 
ATOM   6450 O O   . GLY D 2 205 ? 26.865  -9.524  73.951  1.00 43.00  ? 205 GLY L O   1 
ATOM   6451 N N   . LEU D 2 206 ? 24.595  -9.440  73.612  1.00 46.01  ? 206 LEU L N   1 
ATOM   6452 C CA  . LEU D 2 206 ? 24.163  -9.165  74.977  1.00 52.19  ? 206 LEU L CA  1 
ATOM   6453 C C   . LEU D 2 206 ? 23.519  -10.404 75.589  1.00 54.49  ? 206 LEU L C   1 
ATOM   6454 O O   . LEU D 2 206 ? 22.501  -10.861 75.073  1.00 52.16  ? 206 LEU L O   1 
ATOM   6455 C CB  . LEU D 2 206 ? 23.083  -8.078  74.957  1.00 53.64  ? 206 LEU L CB  1 
ATOM   6456 C CG  . LEU D 2 206 ? 23.535  -6.650  74.673  1.00 52.77  ? 206 LEU L CG  1 
ATOM   6457 C CD1 . LEU D 2 206 ? 22.354  -5.699  74.855  1.00 54.10  ? 206 LEU L CD1 1 
ATOM   6458 C CD2 . LEU D 2 206 ? 24.712  -6.257  75.559  1.00 52.60  ? 206 LEU L CD2 1 
ATOM   6459 N N   . SER D 2 207 ? 24.040  -10.853 76.739  1.00 62.63  ? 207 SER L N   1 
ATOM   6460 C CA  . SER D 2 207 ? 23.397  -11.901 77.520  1.00 60.33  ? 207 SER L CA  1 
ATOM   6461 C C   . SER D 2 207 ? 21.915  -11.571 77.762  1.00 63.61  ? 207 SER L C   1 
ATOM   6462 O O   . SER D 2 207 ? 21.061  -12.424 77.517  1.00 61.40  ? 207 SER L O   1 
ATOM   6463 C CB  . SER D 2 207 ? 24.151  -12.135 78.806  1.00 56.37  ? 207 SER L CB  1 
ATOM   6464 O OG  . SER D 2 207 ? 24.049  -10.998 79.652  1.00 59.63  ? 207 SER L OG  1 
ATOM   6465 N N   . SER D 2 208 ? 21.602  -10.338 78.215  1.00 58.51  ? 208 SER L N   1 
ATOM   6466 C CA  . SER D 2 208 ? 20.229  -9.939  78.528  1.00 58.08  ? 208 SER L CA  1 
ATOM   6467 C C   . SER D 2 208 ? 19.994  -8.482  78.136  1.00 52.30  ? 208 SER L C   1 
ATOM   6468 O O   . SER D 2 208 ? 20.971  -7.778  77.922  1.00 54.62  ? 208 SER L O   1 
ATOM   6469 C CB  . SER D 2 208 ? 19.900  -10.165 79.999  1.00 58.37  ? 208 SER L CB  1 
ATOM   6470 O OG  . SER D 2 208 ? 21.059  -10.093 80.816  1.00 63.62  ? 208 SER L OG  1 
ATOM   6471 N N   . PRO D 2 209 ? 18.722  -7.993  78.054  1.00 57.26  ? 209 PRO L N   1 
ATOM   6472 C CA  . PRO D 2 209 ? 18.419  -6.608  77.663  1.00 59.48  ? 209 PRO L CA  1 
ATOM   6473 C C   . PRO D 2 209 ? 18.955  -5.537  78.616  1.00 59.85  ? 209 PRO L C   1 
ATOM   6474 O O   . PRO D 2 209 ? 18.357  -5.302  79.663  1.00 69.91  ? 209 PRO L O   1 
ATOM   6475 C CB  . PRO D 2 209 ? 16.876  -6.470  77.656  1.00 56.75  ? 209 PRO L CB  1 
ATOM   6476 C CG  . PRO D 2 209 ? 16.326  -7.872  77.874  1.00 59.28  ? 209 PRO L CG  1 
ATOM   6477 C CD  . PRO D 2 209 ? 17.485  -8.754  78.317  1.00 61.63  ? 209 PRO L CD  1 
ATOM   6478 N N   . VAL D 2 210 ? 20.036  -4.846  78.215  1.00 56.05  ? 210 VAL L N   1 
ATOM   6479 C CA  . VAL D 2 210 ? 20.631  -3.791  79.027  1.00 52.43  ? 210 VAL L CA  1 
ATOM   6480 C C   . VAL D 2 210 ? 19.685  -2.582  79.063  1.00 53.86  ? 210 VAL L C   1 
ATOM   6481 O O   . VAL D 2 210 ? 19.013  -2.253  78.084  1.00 51.98  ? 210 VAL L O   1 
ATOM   6482 C CB  . VAL D 2 210 ? 22.057  -3.438  78.549  1.00 52.73  ? 210 VAL L CB  1 
ATOM   6483 C CG1 . VAL D 2 210 ? 22.545  -2.097  79.080  1.00 49.26  ? 210 VAL L CG1 1 
ATOM   6484 C CG2 . VAL D 2 210 ? 23.062  -4.542  78.890  1.00 50.94  ? 210 VAL L CG2 1 
ATOM   6485 N N   . THR D 2 211 ? 19.596  -1.967  80.250  1.00 57.09  ? 211 THR L N   1 
ATOM   6486 C CA  . THR D 2 211 ? 18.826  -0.755  80.455  1.00 54.84  ? 211 THR L CA  1 
ATOM   6487 C C   . THR D 2 211 ? 19.742  0.340   81.000  1.00 50.37  ? 211 THR L C   1 
ATOM   6488 O O   . THR D 2 211 ? 20.754  0.080   81.647  1.00 47.59  ? 211 THR L O   1 
ATOM   6489 C CB  . THR D 2 211 ? 17.625  -1.004  81.381  1.00 61.57  ? 211 THR L CB  1 
ATOM   6490 O OG1 . THR D 2 211 ? 16.839  -2.047  80.803  1.00 69.77  ? 211 THR L OG1 1 
ATOM   6491 C CG2 . THR D 2 211 ? 16.748  0.217   81.596  1.00 62.25  ? 211 THR L CG2 1 
ATOM   6492 N N   . LYS D 2 212 ? 19.383  1.579   80.674  1.00 46.77  ? 212 LYS L N   1 
ATOM   6493 C CA  . LYS D 2 212 ? 20.060  2.753   81.176  1.00 46.92  ? 212 LYS L CA  1 
ATOM   6494 C C   . LYS D 2 212 ? 18.969  3.771   81.433  1.00 47.22  ? 212 LYS L C   1 
ATOM   6495 O O   . LYS D 2 212 ? 18.125  3.982   80.560  1.00 49.41  ? 212 LYS L O   1 
ATOM   6496 C CB  . LYS D 2 212 ? 21.033  3.333   80.145  1.00 46.25  ? 212 LYS L CB  1 
ATOM   6497 C CG  . LYS D 2 212 ? 22.129  2.396   79.672  1.00 46.62  ? 212 LYS L CG  1 
ATOM   6498 C CD  . LYS D 2 212 ? 23.157  2.139   80.723  1.00 43.41  ? 212 LYS L CD  1 
ATOM   6499 C CE  . LYS D 2 212 ? 24.227  1.200   80.230  1.00 42.24  ? 212 LYS L CE  1 
ATOM   6500 N NZ  . LYS D 2 212 ? 25.394  1.242   81.126  1.00 43.74  ? 212 LYS L NZ  1 
ATOM   6501 N N   . SER D 2 213 ? 18.992  4.404   82.608  1.00 50.77  ? 213 SER L N   1 
ATOM   6502 C CA  . SER D 2 213 ? 17.883  5.270   82.973  1.00 47.97  ? 213 SER L CA  1 
ATOM   6503 C C   . SER D 2 213 ? 18.345  6.377   83.901  1.00 44.61  ? 213 SER L C   1 
ATOM   6504 O O   . SER D 2 213 ? 19.461  6.366   84.407  1.00 42.12  ? 213 SER L O   1 
ATOM   6505 C CB  . SER D 2 213 ? 16.771  4.475   83.601  1.00 45.08  ? 213 SER L CB  1 
ATOM   6506 O OG  . SER D 2 213 ? 17.255  3.825   84.753  1.00 48.09  ? 213 SER L OG  1 
ATOM   6507 N N   . PHE D 2 214 ? 17.421  7.312   84.098  1.00 50.90  ? 214 PHE L N   1 
ATOM   6508 C CA  . PHE D 2 214 ? 17.607  8.477   84.936  1.00 49.54  ? 214 PHE L CA  1 
ATOM   6509 C C   . PHE D 2 214 ? 16.232  8.879   85.464  1.00 50.47  ? 214 PHE L C   1 
ATOM   6510 O O   . PHE D 2 214 ? 15.217  8.432   84.923  1.00 50.73  ? 214 PHE L O   1 
ATOM   6511 C CB  . PHE D 2 214 ? 18.238  9.604   84.111  1.00 48.91  ? 214 PHE L CB  1 
ATOM   6512 C CG  . PHE D 2 214 ? 17.377  10.139  82.988  1.00 46.16  ? 214 PHE L CG  1 
ATOM   6513 C CD1 . PHE D 2 214 ? 17.285  9.476   81.773  1.00 45.78  ? 214 PHE L CD1 1 
ATOM   6514 C CD2 . PHE D 2 214 ? 16.644  11.307  83.153  1.00 47.12  ? 214 PHE L CD2 1 
ATOM   6515 C CE1 . PHE D 2 214 ? 16.504  9.987   80.747  1.00 44.64  ? 214 PHE L CE1 1 
ATOM   6516 C CE2 . PHE D 2 214 ? 15.854  11.808  82.127  1.00 47.98  ? 214 PHE L CE2 1 
ATOM   6517 C CZ  . PHE D 2 214 ? 15.794  11.152  80.922  1.00 42.02  ? 214 PHE L CZ  1 
ATOM   6518 N N   . ASN D 2 215 ? 16.214  9.755   86.478  1.00 47.51  ? 215 ASN L N   1 
ATOM   6519 C CA  . ASN D 2 215 ? 14.971  10.278  87.021  1.00 50.36  ? 215 ASN L CA  1 
ATOM   6520 C C   . ASN D 2 215 ? 14.922  11.783  86.774  1.00 48.36  ? 215 ASN L C   1 
ATOM   6521 O O   . ASN D 2 215 ? 15.923  12.471  86.951  1.00 47.78  ? 215 ASN L O   1 
ATOM   6522 C CB  . ASN D 2 215 ? 14.831  9.851   88.483  1.00 55.10  ? 215 ASN L CB  1 
ATOM   6523 C CG  . ASN D 2 215 ? 14.794  8.341   88.618  1.00 57.37  ? 215 ASN L CG  1 
ATOM   6524 O OD1 . ASN D 2 215 ? 13.787  7.714   88.297  1.00 62.69  ? 215 ASN L OD1 1 
ATOM   6525 N ND2 . ASN D 2 215 ? 15.894  7.744   89.049  1.00 54.39  ? 215 ASN L ND2 1 
ATOM   6526 N N   . ARG D 2 216 ? 13.731  12.282  86.408  1.00 50.45  ? 216 ARG L N   1 
ATOM   6527 C CA  . ARG D 2 216 ? 13.559  13.588  85.782  1.00 57.76  ? 216 ARG L CA  1 
ATOM   6528 C C   . ARG D 2 216 ? 14.336  14.707  86.502  1.00 57.21  ? 216 ARG L C   1 
ATOM   6529 O O   . ARG D 2 216 ? 14.616  14.562  87.705  1.00 60.37  ? 216 ARG L O   1 
ATOM   6530 C CB  . ARG D 2 216 ? 12.069  13.941  85.698  1.00 65.18  ? 216 ARG L CB  1 
ATOM   6531 C CG  . ARG D 2 216 ? 11.800  15.306  85.077  1.00 66.37  ? 216 ARG L CG  1 
ATOM   6532 C CD  . ARG D 2 216 ? 10.464  15.461  84.368  1.00 70.80  ? 216 ARG L CD  1 
ATOM   6533 N NE  . ARG D 2 216 ? 9.304   14.865  85.018  1.00 77.02  ? 216 ARG L NE  1 
ATOM   6534 C CZ  . ARG D 2 216 ? 8.941   15.059  86.280  1.00 81.85  ? 216 ARG L CZ  1 
ATOM   6535 N NH1 . ARG D 2 216 ? 9.654   15.831  87.079  1.00 82.99  ? 216 ARG L NH1 1 
ATOM   6536 N NH2 . ARG D 2 216 ? 7.862   14.456  86.748  1.00 88.83  ? 216 ARG L NH2 1 
HETATM 6537 O OAB . PEU E 3 .   ? -12.044 -0.871  -26.351 1.00 29.67  ? 301 PEU A OAB 1 
HETATM 6538 C CAC . PEU E 3 .   ? -13.022 -0.740  -27.515 1.00 32.02  ? 301 PEU A CAC 1 
HETATM 6539 C CAD . PEU E 3 .   ? -14.527 -0.469  -27.104 1.00 31.72  ? 301 PEU A CAD 1 
HETATM 6540 O OAE . PEU E 3 .   ? -15.139 -1.626  -26.505 1.00 35.90  ? 301 PEU A OAE 1 
HETATM 6541 C CAF . PEU E 3 .   ? -16.502 -1.387  -25.987 1.00 34.81  ? 301 PEU A CAF 1 
HETATM 6542 C CAG . PEU E 3 .   ? -17.573 -1.286  -27.087 1.00 24.82  ? 301 PEU A CAG 1 
HETATM 6543 O OAH . PEU E 3 .   ? -18.807 -1.830  -26.741 1.00 25.04  ? 301 PEU A OAH 1 
HETATM 6544 C CAI . PEU E 3 .   ? -19.879 -2.139  -27.715 1.00 22.67  ? 301 PEU A CAI 1 
HETATM 6545 C CAJ . PEU E 3 .   ? -20.123 -0.978  -28.614 1.00 22.34  ? 301 PEU A CAJ 1 
HETATM 6546 O OAK . PEU E 3 .   ? -21.373 -0.579  -29.026 1.00 22.70  ? 301 PEU A OAK 1 
HETATM 6547 C CAL . PEU E 3 .   ? -22.275 -1.613  -29.597 1.00 22.05  ? 301 PEU A CAL 1 
HETATM 6548 C CAM . PEU E 3 .   ? -23.261 -1.931  -28.525 1.00 19.28  ? 301 PEU A CAM 1 
HETATM 6549 O OAN . PEU E 3 .   ? -23.954 -3.186  -28.460 1.00 26.29  ? 301 PEU A OAN 1 
HETATM 6550 C CAO . PEU E 3 .   ? -24.563 -3.429  -27.094 1.00 20.67  ? 301 PEU A CAO 1 
HETATM 6551 C CAP . PEU E 3 .   ? -25.746 -2.657  -26.688 1.00 20.96  ? 301 PEU A CAP 1 
HETATM 6552 O OAQ . PEU E 3 .   ? -25.988 -2.392  -25.224 1.00 24.98  ? 301 PEU A OAQ 1 
HETATM 6553 C CAR . PEU E 3 .   ? -27.113 -1.454  -24.987 1.00 24.88  ? 301 PEU A CAR 1 
HETATM 6554 C CAS . PEU E 3 .   ? -26.783 -0.157  -24.174 1.00 30.21  ? 301 PEU A CAS 1 
HETATM 6555 O OAT . PEU E 3 .   ? -27.072 -0.233  -22.696 1.00 31.51  ? 301 PEU A OAT 1 
HETATM 6556 C CAU . PEU E 3 .   ? -26.262 0.555   -21.836 1.00 29.68  ? 301 PEU A CAU 1 
HETATM 6557 C CAV . PEU E 3 .   ? -25.849 -0.104  -20.484 1.00 30.41  ? 301 PEU A CAV 1 
HETATM 6558 O OAW . PEU E 3 .   ? -24.922 -1.249  -20.634 1.00 32.88  ? 301 PEU A OAW 1 
HETATM 6559 C CAX . PEU E 3 .   ? -23.724 -1.038  -19.878 1.00 30.84  ? 301 PEU A CAX 1 
HETATM 6560 C CAY . PEU E 3 .   ? -22.728 -2.192  -20.070 1.00 28.32  ? 301 PEU A CAY 1 
HETATM 6561 O OAZ . PEU E 3 .   ? -23.331 -3.454  -20.325 1.00 29.19  ? 301 PEU A OAZ 1 
HETATM 6562 C CBA . PEU E 3 .   ? -22.395 -4.573  -20.463 1.00 28.74  ? 301 PEU A CBA 1 
HETATM 6563 C CBB . PEU E 3 .   ? -22.829 -5.798  -19.664 1.00 30.46  ? 301 PEU A CBB 1 
HETATM 6564 O OBC . PEU E 3 .   ? -21.688 -6.476  -19.229 1.00 37.56  ? 301 PEU A OBC 1 
HETATM 6565 C CCG . PEU E 3 .   ? -21.623 -7.235  -18.006 1.00 33.73  ? 301 PEU A CCG 1 
HETATM 6566 C CCF . PEU E 3 .   ? -20.287 -8.046  -17.857 1.00 35.50  ? 301 PEU A CCF 1 
HETATM 6567 O OCE . PEU E 3 .   ? -19.094 -7.316  -18.214 1.00 37.16  ? 301 PEU A OCE 1 
HETATM 6568 C CCD . PEU E 3 .   ? -17.815 -7.632  -17.593 1.00 31.48  ? 301 PEU A CCD 1 
HETATM 6569 C CCC . PEU E 3 .   ? -16.829 -8.247  -18.580 1.00 30.37  ? 301 PEU A CCC 1 
HETATM 6570 O OCB . PEU E 3 .   ? -16.290 -7.295  -19.490 1.00 31.26  ? 301 PEU A OCB 1 
HETATM 6571 C CCA . PEU E 3 .   ? -15.861 -7.883  -20.741 1.00 26.39  ? 301 PEU A CCA 1 
HETATM 6572 C CBZ . PEU E 3 .   ? -15.262 -6.849  -21.678 1.00 24.81  ? 301 PEU A CBZ 1 
HETATM 6573 O OBY . PEU E 3 .   ? -16.120 -6.265  -22.723 1.00 23.56  ? 301 PEU A OBY 1 
HETATM 6574 C CBX . PEU E 3 .   ? -15.435 -5.036  -23.305 1.00 26.77  ? 301 PEU A CBX 1 
HETATM 6575 C CBW . PEU E 3 .   ? -16.192 -3.741  -22.942 1.00 28.46  ? 301 PEU A CBW 1 
HETATM 6576 O OBV . PEU E 3 .   ? -15.504 -2.602  -22.307 1.00 36.24  ? 301 PEU A OBV 1 
HETATM 6577 C CBU . PEU E 3 .   ? -16.386 -1.408  -21.977 1.00 28.69  ? 301 PEU A CBU 1 
HETATM 6578 C CBT . PEU E 3 .   ? -16.361 -0.830  -20.562 1.00 25.13  ? 301 PEU A CBT 1 
HETATM 6579 O OBS . PEU E 3 .   ? -17.496 -1.172  -19.680 1.00 29.93  ? 301 PEU A OBS 1 
HETATM 6580 C CBR . PEU E 3 .   ? -18.269 -0.047  -19.096 1.00 28.67  ? 301 PEU A CBR 1 
HETATM 6581 C CBQ . PEU E 3 .   ? -19.752 -0.233  -18.791 1.00 29.54  ? 301 PEU A CBQ 1 
HETATM 6582 O OBP . PEU E 3 .   ? -20.389 1.138   -18.672 1.00 37.88  ? 301 PEU A OBP 1 
HETATM 6583 C CBO . PEU E 3 .   ? -21.496 1.268   -17.755 1.00 28.60  ? 301 PEU A CBO 1 
HETATM 6584 C CBN . PEU E 3 .   ? -22.251 2.609   -17.700 1.00 28.37  ? 301 PEU A CBN 1 
HETATM 6585 O OBM . PEU E 3 .   ? -22.695 2.888   -16.285 1.00 29.71  ? 301 PEU A OBM 1 
HETATM 6586 C CBL . PEU E 3 .   ? -21.654 3.586   -15.545 1.00 30.54  ? 301 PEU A CBL 1 
HETATM 6587 C CBK . PEU E 3 .   ? -21.625 3.391   -14.020 1.00 31.58  ? 301 PEU A CBK 1 
HETATM 6588 O OBJ . PEU E 3 .   ? -20.653 2.377   -13.539 1.00 30.93  ? 301 PEU A OBJ 1 
HETATM 6589 C CBI . PEU E 3 .   ? -19.240 2.642   -13.339 1.00 28.56  ? 301 PEU A CBI 1 
HETATM 6590 C CBH . PEU E 3 .   ? -18.488 1.254   -13.337 1.00 26.47  ? 301 PEU A CBH 1 
HETATM 6591 O OBG . PEU E 3 .   ? -18.376 0.681   -12.010 1.00 24.79  ? 301 PEU A OBG 1 
HETATM 6592 C CBF . PEU E 3 .   ? -18.195 -0.757  -11.733 1.00 24.87  ? 301 PEU A CBF 1 
HETATM 6593 C CBE . PEU E 3 .   ? -18.641 -1.067  -10.332 1.00 23.28  ? 301 PEU A CBE 1 
HETATM 6594 O OBD . PEU E 3 .   ? -18.996 -2.420  -10.054 1.00 27.46  ? 301 PEU A OBD 1 
HETATM 6595 C CCH . PEU E 3 .   ? -20.376 -2.740  -9.926  1.00 31.38  ? 301 PEU A CCH 1 
HETATM 6596 C CCI . PEU E 3 .   ? -20.744 -4.060  -10.506 1.00 30.47  ? 301 PEU A CCI 1 
HETATM 6597 O OCJ . PEU E 3 .   ? -19.658 -4.622  -11.207 1.00 37.09  ? 301 PEU A OCJ 1 
HETATM 6598 C CCK . PEU E 3 .   ? -19.472 -4.265  -12.513 1.00 34.21  ? 301 PEU A CCK 1 
HETATM 6599 C CCL . PEU E 3 .   ? -19.567 -5.490  -13.376 1.00 34.05  ? 301 PEU A CCL 1 
HETATM 6600 O OCM . PEU E 3 .   ? -20.610 -6.410  -13.058 1.00 33.60  ? 301 PEU A OCM 1 
HETATM 6601 C CCN . PEU E 3 .   ? -20.720 -7.309  -14.244 1.00 37.64  ? 301 PEU A CCN 1 
HETATM 6602 C CCO . PEU E 3 .   ? -20.343 -8.767  -13.924 1.00 38.56  ? 301 PEU A CCO 1 
HETATM 6603 O OCP . PEU E 3 .   ? -21.488 -9.485  -13.391 1.00 35.45  ? 301 PEU A OCP 1 
HETATM 6604 C CCQ . PEU E 3 .   ? -21.256 -10.923 -13.296 1.00 35.62  ? 301 PEU A CCQ 1 
HETATM 6605 C CCR . PEU E 3 .   ? -21.516 -11.620 -14.671 1.00 37.98  ? 301 PEU A CCR 1 
HETATM 6606 O OCS . PEU E 3 .   ? -21.314 -13.044 -14.624 1.00 42.78  ? 301 PEU A OCS 1 
HETATM 6607 C C1  . IPA F 4 .   ? -14.564 5.246   -20.090 1.00 30.59  ? 301 IPA B C1  1 
HETATM 6608 C C2  . IPA F 4 .   ? -15.514 4.404   -19.269 1.00 32.42  ? 301 IPA B C2  1 
HETATM 6609 C C3  . IPA F 4 .   ? -15.004 3.036   -18.948 1.00 30.94  ? 301 IPA B C3  1 
HETATM 6610 O O2  . IPA F 4 .   ? -15.900 5.072   -18.049 1.00 32.42  ? 301 IPA B O2  1 
HETATM 6611 O O   . HOH G 5 .   ? -28.124 -19.532 1.780   1.00 30.83  ? 401 HOH A O   1 
HETATM 6612 O O   . HOH G 5 .   ? -26.913 -22.924 3.270   1.00 37.64  ? 402 HOH A O   1 
HETATM 6613 O O   . HOH G 5 .   ? -30.927 0.510   -3.950  1.00 41.85  ? 403 HOH A O   1 
HETATM 6614 O O   . HOH G 5 .   ? -31.471 -4.375  -13.640 1.00 24.44  ? 404 HOH A O   1 
HETATM 6615 O O   . HOH G 5 .   ? -32.525 -21.617 -12.940 1.00 33.66  ? 405 HOH A O   1 
HETATM 6616 O O   . HOH G 5 .   ? -23.932 -3.452  -7.483  1.00 21.16  ? 406 HOH A O   1 
HETATM 6617 O O   . HOH G 5 .   ? -16.368 -12.343 1.608   1.00 25.47  ? 407 HOH A O   1 
HETATM 6618 O O   . HOH G 5 .   ? -35.499 -6.416  3.956   1.00 29.93  ? 408 HOH A O   1 
HETATM 6619 O O   . HOH G 5 .   ? -18.681 -6.689  -20.815 1.00 18.93  ? 409 HOH A O   1 
HETATM 6620 O O   . HOH G 5 .   ? -30.050 -0.220  -0.536  1.00 36.35  ? 410 HOH A O   1 
HETATM 6621 O O   . HOH G 5 .   ? -24.585 -0.523  -9.665  1.00 18.93  ? 411 HOH A O   1 
HETATM 6622 O O   . HOH G 5 .   ? -27.005 1.044   -3.008  1.00 29.45  ? 412 HOH A O   1 
HETATM 6623 O O   . HOH G 5 .   ? -25.274 7.254   -7.845  1.00 41.27  ? 413 HOH A O   1 
HETATM 6624 O O   . HOH G 5 .   ? -33.330 -12.933 -10.300 1.00 30.25  ? 414 HOH A O   1 
HETATM 6625 O O   . HOH G 5 .   ? -28.362 -21.411 22.610  1.00 42.82  ? 415 HOH A O   1 
HETATM 6626 O O   . HOH G 5 .   ? -23.879 -10.032 9.923   1.00 47.00  ? 416 HOH A O   1 
HETATM 6627 O O   . HOH G 5 .   ? -28.095 -10.563 -23.818 1.00 28.43  ? 417 HOH A O   1 
HETATM 6628 O O   . HOH G 5 .   ? -34.280 -28.765 5.759   1.00 48.67  ? 418 HOH A O   1 
HETATM 6629 O O   . HOH G 5 .   ? -27.862 -31.094 2.445   1.00 47.54  ? 419 HOH A O   1 
HETATM 6630 O O   . HOH G 5 .   ? -31.974 -5.811  6.184   1.00 41.04  ? 420 HOH A O   1 
HETATM 6631 O O   . HOH G 5 .   ? -23.180 -23.054 -0.336  1.00 49.52  ? 421 HOH A O   1 
HETATM 6632 O O   . HOH G 5 .   ? -32.851 -18.061 -20.319 1.00 56.62  ? 422 HOH A O   1 
HETATM 6633 O O   . HOH G 5 .   ? -33.885 -0.548  -24.249 1.00 46.82  ? 423 HOH A O   1 
HETATM 6634 O O   . HOH G 5 .   ? -44.077 -12.080 5.618   1.00 40.74  ? 424 HOH A O   1 
HETATM 6635 O O   . HOH G 5 .   ? -26.377 -11.036 13.138  1.00 37.30  ? 425 HOH A O   1 
HETATM 6636 O O   . HOH G 5 .   ? -42.020 -5.673  -0.606  1.00 45.15  ? 426 HOH A O   1 
HETATM 6637 O O   . HOH H 5 .   ? -17.802 6.304   3.713   1.00 34.68  ? 401 HOH B O   1 
HETATM 6638 O O   . HOH H 5 .   ? -6.754  -10.242 -17.825 1.00 21.72  ? 402 HOH B O   1 
HETATM 6639 O O   . HOH H 5 .   ? -18.860 -7.047  6.719   1.00 24.42  ? 403 HOH B O   1 
HETATM 6640 O O   . HOH H 5 .   ? -21.601 -2.139  -6.564  1.00 13.39  ? 404 HOH B O   1 
HETATM 6641 O O   . HOH H 5 .   ? -0.656  -4.733  -14.605 1.00 29.14  ? 405 HOH B O   1 
HETATM 6642 O O   . HOH H 5 .   ? -16.772 3.901   -15.899 1.00 30.37  ? 406 HOH B O   1 
HETATM 6643 O O   . HOH H 5 .   ? -4.328  0.880   -16.710 1.00 31.53  ? 407 HOH B O   1 
HETATM 6644 O O   . HOH H 5 .   ? -12.480 5.639   -14.443 1.00 30.65  ? 408 HOH B O   1 
HETATM 6645 O O   . HOH H 5 .   ? -5.065  7.451   0.137   1.00 31.04  ? 409 HOH B O   1 
HETATM 6646 O O   . HOH H 5 .   ? -5.780  -14.551 -4.541  1.00 29.09  ? 410 HOH B O   1 
HETATM 6647 O O   . HOH H 5 .   ? -7.891  -13.430 -15.607 1.00 31.67  ? 411 HOH B O   1 
HETATM 6648 O O   . HOH H 5 .   ? -1.440  -2.947  6.271   1.00 34.32  ? 412 HOH B O   1 
HETATM 6649 O O   . HOH H 5 .   ? -3.629  -10.324 0.186   1.00 27.29  ? 413 HOH B O   1 
HETATM 6650 O O   . HOH H 5 .   ? -5.933  2.331   38.123  1.00 55.59  ? 414 HOH B O   1 
HETATM 6651 O O   . HOH H 5 .   ? -16.367 -4.347  -19.980 1.00 19.74  ? 415 HOH B O   1 
HETATM 6652 O O   . HOH H 5 .   ? -7.888  0.640   -14.245 1.00 22.43  ? 416 HOH B O   1 
HETATM 6653 O O   . HOH H 5 .   ? -11.673 -11.435 -24.190 1.00 24.86  ? 417 HOH B O   1 
HETATM 6654 O O   . HOH H 5 .   ? -8.629  2.754   -20.110 1.00 13.04  ? 418 HOH B O   1 
HETATM 6655 O O   . HOH H 5 .   ? -24.342 -5.023  7.632   1.00 44.86  ? 419 HOH B O   1 
HETATM 6656 O O   . HOH H 5 .   ? -7.848  6.140   -5.958  1.00 27.38  ? 420 HOH B O   1 
HETATM 6657 O O   . HOH H 5 .   ? -7.056  -0.945  -5.920  1.00 18.63  ? 421 HOH B O   1 
HETATM 6658 O O   . HOH H 5 .   ? -3.873  -7.533  -19.365 1.00 24.88  ? 422 HOH B O   1 
HETATM 6659 O O   . HOH H 5 .   ? -10.608 8.939   -9.011  1.00 30.79  ? 423 HOH B O   1 
HETATM 6660 O O   . HOH H 5 .   ? -19.545 6.250   -11.753 1.00 33.77  ? 424 HOH B O   1 
HETATM 6661 O O   . HOH H 5 .   ? -9.426  -12.698 1.777   1.00 25.06  ? 425 HOH B O   1 
HETATM 6662 O O   . HOH H 5 .   ? -1.852  -0.105  7.534   1.00 27.21  ? 426 HOH B O   1 
HETATM 6663 O O   . HOH H 5 .   ? -17.628 -14.022 -3.775  1.00 17.49  ? 427 HOH B O   1 
HETATM 6664 O O   . HOH H 5 .   ? -2.212  -6.073  -20.633 1.00 22.25  ? 428 HOH B O   1 
HETATM 6665 O O   . HOH H 5 .   ? -0.800  -9.150  -13.648 1.00 46.61  ? 429 HOH B O   1 
HETATM 6666 O O   . HOH H 5 .   ? -7.355  7.053   -13.097 1.00 45.33  ? 430 HOH B O   1 
HETATM 6667 O O   . HOH H 5 .   ? -3.748  -6.946  30.567  1.00 56.80  ? 431 HOH B O   1 
HETATM 6668 O O   . HOH H 5 .   ? -9.189  -15.319 1.747   1.00 28.71  ? 432 HOH B O   1 
HETATM 6669 O O   . HOH H 5 .   ? -28.586 1.276   7.552   1.00 47.65  ? 433 HOH B O   1 
HETATM 6670 O O   . HOH H 5 .   ? -7.980  -9.701  31.759  1.00 47.83  ? 434 HOH B O   1 
HETATM 6671 O O   . HOH H 5 .   ? -30.027 -0.341  4.701   1.00 43.56  ? 435 HOH B O   1 
HETATM 6672 O O   . HOH I 5 .   ? 15.074  22.005  28.241  1.00 26.85  ? 301 HOH H O   1 
HETATM 6673 O O   . HOH I 5 .   ? 6.982   8.810   42.258  1.00 23.82  ? 302 HOH H O   1 
HETATM 6674 O O   . HOH I 5 .   ? 27.204  6.427   22.528  1.00 23.95  ? 303 HOH H O   1 
HETATM 6675 O O   . HOH I 5 .   ? 27.351  3.378   34.636  1.00 18.26  ? 304 HOH H O   1 
HETATM 6676 O O   . HOH I 5 .   ? 9.062   19.626  64.786  1.00 30.19  ? 305 HOH H O   1 
HETATM 6677 O O   . HOH I 5 .   ? 24.043  30.083  53.496  1.00 21.06  ? 306 HOH H O   1 
HETATM 6678 O O   . HOH I 5 .   ? 8.806   -0.970  37.490  1.00 33.66  ? 307 HOH H O   1 
HETATM 6679 O O   . HOH I 5 .   ? 2.003   9.830   27.948  1.00 28.50  ? 308 HOH H O   1 
HETATM 6680 O O   . HOH I 5 .   ? 22.465  9.679   42.620  1.00 20.66  ? 309 HOH H O   1 
HETATM 6681 O O   . HOH I 5 .   ? 7.058   4.791   17.900  1.00 32.18  ? 310 HOH H O   1 
HETATM 6682 O O   . HOH I 5 .   ? 14.468  19.290  38.132  1.00 23.92  ? 311 HOH H O   1 
HETATM 6683 O O   . HOH I 5 .   ? 32.255  6.264   69.008  1.00 34.21  ? 312 HOH H O   1 
HETATM 6684 O O   . HOH I 5 .   ? 23.822  22.696  54.855  1.00 22.97  ? 313 HOH H O   1 
HETATM 6685 O O   . HOH I 5 .   ? 35.023  24.369  67.187  1.00 27.34  ? 314 HOH H O   1 
HETATM 6686 O O   . HOH I 5 .   ? 14.734  18.575  47.188  1.00 26.84  ? 315 HOH H O   1 
HETATM 6687 O O   . HOH I 5 .   ? 17.194  2.270   21.792  1.00 21.68  ? 316 HOH H O   1 
HETATM 6688 O O   . HOH I 5 .   ? 33.338  20.902  76.600  1.00 34.40  ? 317 HOH H O   1 
HETATM 6689 O O   . HOH I 5 .   ? 20.103  16.522  57.132  1.00 31.83  ? 318 HOH H O   1 
HETATM 6690 O O   . HOH I 5 .   ? 11.201  11.615  28.639  1.00 16.96  ? 319 HOH H O   1 
HETATM 6691 O O   . HOH I 5 .   ? 25.183  20.116  26.652  1.00 42.06  ? 320 HOH H O   1 
HETATM 6692 O O   . HOH I 5 .   ? 7.051   15.249  29.986  1.00 24.70  ? 321 HOH H O   1 
HETATM 6693 O O   . HOH I 5 .   ? 19.299  7.428   44.824  1.00 25.52  ? 322 HOH H O   1 
HETATM 6694 O O   . HOH I 5 .   ? 25.696  13.724  34.651  1.00 24.32  ? 323 HOH H O   1 
HETATM 6695 O O   . HOH I 5 .   ? 15.234  -2.529  43.004  1.00 18.15  ? 324 HOH H O   1 
HETATM 6696 O O   . HOH I 5 .   ? 29.671  14.700  61.159  1.00 33.46  ? 325 HOH H O   1 
HETATM 6697 O O   . HOH I 5 .   ? 23.869  3.601   28.012  1.00 13.12  ? 326 HOH H O   1 
HETATM 6698 O O   . HOH I 5 .   ? 25.705  10.668  35.797  1.00 24.17  ? 327 HOH H O   1 
HETATM 6699 O O   . HOH I 5 .   ? 1.912   7.265   32.386  1.00 15.67  ? 328 HOH H O   1 
HETATM 6700 O O   . HOH I 5 .   ? 17.936  8.704   14.823  1.00 26.42  ? 329 HOH H O   1 
HETATM 6701 O O   . HOH I 5 .   ? -0.139  13.559  34.529  1.00 30.99  ? 330 HOH H O   1 
HETATM 6702 O O   . HOH I 5 .   ? 37.129  10.353  70.360  1.00 23.07  ? 331 HOH H O   1 
HETATM 6703 O O   . HOH I 5 .   ? 40.627  15.668  62.487  1.00 24.47  ? 332 HOH H O   1 
HETATM 6704 O O   . HOH I 5 .   ? 33.414  7.095   63.876  1.00 41.44  ? 333 HOH H O   1 
HETATM 6705 O O   . HOH I 5 .   ? 5.010   23.469  44.813  1.00 42.51  ? 334 HOH H O   1 
HETATM 6706 O O   . HOH I 5 .   ? 12.464  3.068   45.201  1.00 21.04  ? 335 HOH H O   1 
HETATM 6707 O O   . HOH I 5 .   ? 21.717  3.311   31.104  1.00 17.63  ? 336 HOH H O   1 
HETATM 6708 O O   . HOH I 5 .   ? 21.303  19.315  21.383  1.00 28.20  ? 337 HOH H O   1 
HETATM 6709 O O   . HOH I 5 .   ? 15.174  18.505  52.192  1.00 34.40  ? 338 HOH H O   1 
HETATM 6710 O O   . HOH I 5 .   ? 19.806  16.849  40.219  1.00 28.45  ? 339 HOH H O   1 
HETATM 6711 O O   . HOH I 5 .   ? 34.822  16.975  63.177  1.00 26.04  ? 340 HOH H O   1 
HETATM 6712 O O   . HOH I 5 .   ? 17.532  18.612  50.293  1.00 31.41  ? 341 HOH H O   1 
HETATM 6713 O O   . HOH I 5 .   ? 26.373  16.254  21.387  1.00 38.27  ? 342 HOH H O   1 
HETATM 6714 O O   . HOH I 5 .   ? 1.162   14.038  50.303  1.00 38.97  ? 343 HOH H O   1 
HETATM 6715 O O   . HOH I 5 .   ? 13.176  25.175  51.511  1.00 30.15  ? 344 HOH H O   1 
HETATM 6716 O O   . HOH I 5 .   ? 19.246  31.931  53.440  1.00 35.37  ? 345 HOH H O   1 
HETATM 6717 O O   . HOH I 5 .   ? 29.270  6.476   61.680  1.00 37.71  ? 346 HOH H O   1 
HETATM 6718 O O   . HOH I 5 .   ? 29.364  10.085  61.032  1.00 37.87  ? 347 HOH H O   1 
HETATM 6719 O O   . HOH I 5 .   ? 2.389   14.485  34.251  1.00 30.38  ? 348 HOH H O   1 
HETATM 6720 O O   . HOH I 5 .   ? -2.403  19.124  48.359  1.00 49.79  ? 349 HOH H O   1 
HETATM 6721 O O   . HOH I 5 .   ? 11.407  3.679   16.143  1.00 21.11  ? 350 HOH H O   1 
HETATM 6722 O O   . HOH I 5 .   ? 18.928  16.665  42.630  1.00 20.33  ? 351 HOH H O   1 
HETATM 6723 O O   . HOH I 5 .   ? 11.980  23.355  43.135  1.00 33.75  ? 352 HOH H O   1 
HETATM 6724 O O   . HOH I 5 .   ? 27.977  16.139  59.028  1.00 25.97  ? 353 HOH H O   1 
HETATM 6725 O O   . HOH I 5 .   ? 21.849  14.529  18.805  1.00 34.84  ? 354 HOH H O   1 
HETATM 6726 O O   . HOH I 5 .   ? 9.031   21.829  37.775  1.00 45.98  ? 355 HOH H O   1 
HETATM 6727 O O   . HOH I 5 .   ? 17.363  19.463  47.724  1.00 31.84  ? 356 HOH H O   1 
HETATM 6728 O O   . HOH I 5 .   ? 26.237  21.611  77.368  1.00 41.03  ? 357 HOH H O   1 
HETATM 6729 O O   . HOH I 5 .   ? 12.244  -2.425  38.099  1.00 8.38   ? 358 HOH H O   1 
HETATM 6730 O O   . HOH I 5 .   ? 20.580  20.445  43.024  1.00 32.95  ? 359 HOH H O   1 
HETATM 6731 O O   . HOH I 5 .   ? 40.890  20.903  62.586  1.00 36.37  ? 360 HOH H O   1 
HETATM 6732 O O   . HOH I 5 .   ? 21.405  26.822  50.309  1.00 28.35  ? 361 HOH H O   1 
HETATM 6733 O O   . HOH I 5 .   ? 18.809  20.983  30.459  1.00 29.29  ? 362 HOH H O   1 
HETATM 6734 O O   . HOH I 5 .   ? 35.649  16.328  20.759  1.00 43.49  ? 363 HOH H O   1 
HETATM 6735 O O   . HOH I 5 .   ? 6.316   23.509  61.903  1.00 44.61  ? 364 HOH H O   1 
HETATM 6736 O O   . HOH I 5 .   ? 18.900  22.857  26.776  1.00 22.47  ? 365 HOH H O   1 
HETATM 6737 O O   . HOH I 5 .   ? 18.359  7.723   56.117  1.00 37.76  ? 366 HOH H O   1 
HETATM 6738 O O   . HOH I 5 .   ? 32.935  22.859  56.160  1.00 50.51  ? 367 HOH H O   1 
HETATM 6739 O O   . HOH I 5 .   ? 8.741   -3.272  46.275  1.00 46.16  ? 368 HOH H O   1 
HETATM 6740 O O   . HOH J 5 .   ? 8.099   5.284   71.529  1.00 39.00  ? 301 HOH L O   1 
HETATM 6741 O O   . HOH J 5 .   ? 32.062  2.984   32.025  1.00 35.18  ? 302 HOH L O   1 
HETATM 6742 O O   . HOH J 5 .   ? 34.448  -1.518  57.356  1.00 28.05  ? 303 HOH L O   1 
HETATM 6743 O O   . HOH J 5 .   ? 12.061  5.118   67.356  1.00 44.44  ? 304 HOH L O   1 
HETATM 6744 O O   . HOH J 5 .   ? 20.922  1.322   46.398  1.00 21.88  ? 305 HOH L O   1 
HETATM 6745 O O   . HOH J 5 .   ? 37.705  -7.344  31.603  1.00 42.47  ? 306 HOH L O   1 
HETATM 6746 O O   . HOH J 5 .   ? 13.227  -18.719 19.976  1.00 32.59  ? 307 HOH L O   1 
HETATM 6747 O O   . HOH J 5 .   ? 16.385  -19.641 27.054  1.00 23.57  ? 308 HOH L O   1 
HETATM 6748 O O   . HOH J 5 .   ? 12.324  -14.238 39.900  1.00 16.94  ? 309 HOH L O   1 
HETATM 6749 O O   . HOH J 5 .   ? 33.184  -3.889  27.759  1.00 37.09  ? 310 HOH L O   1 
HETATM 6750 O O   . HOH J 5 .   ? 19.834  -20.259 20.564  1.00 27.78  ? 311 HOH L O   1 
HETATM 6751 O O   . HOH J 5 .   ? 11.539  -14.609 28.301  1.00 26.85  ? 312 HOH L O   1 
HETATM 6752 O O   . HOH J 5 .   ? 26.550  5.262   36.129  1.00 20.14  ? 313 HOH L O   1 
HETATM 6753 O O   . HOH J 5 .   ? 25.742  -13.465 26.971  1.00 25.67  ? 314 HOH L O   1 
HETATM 6754 O O   . HOH J 5 .   ? 27.564  4.255   42.533  1.00 14.81  ? 315 HOH L O   1 
HETATM 6755 O O   . HOH J 5 .   ? 40.121  -14.390 47.716  1.00 39.69  ? 316 HOH L O   1 
HETATM 6756 O O   . HOH J 5 .   ? 25.702  -12.709 35.475  1.00 20.98  ? 317 HOH L O   1 
HETATM 6757 O O   . HOH J 5 .   ? 23.131  1.409   32.154  1.00 14.52  ? 318 HOH L O   1 
HETATM 6758 O O   . HOH J 5 .   ? 26.376  -14.001 20.645  1.00 20.40  ? 319 HOH L O   1 
HETATM 6759 O O   . HOH J 5 .   ? 30.538  -1.197  71.778  1.00 37.70  ? 320 HOH L O   1 
HETATM 6760 O O   . HOH J 5 .   ? 29.567  2.610   42.587  1.00 21.19  ? 321 HOH L O   1 
HETATM 6761 O O   . HOH J 5 .   ? 41.246  -6.412  42.188  1.00 23.72  ? 322 HOH L O   1 
HETATM 6762 O O   . HOH J 5 .   ? 26.651  0.125   55.684  1.00 30.85  ? 323 HOH L O   1 
HETATM 6763 O O   . HOH J 5 .   ? 35.212  -12.749 40.277  1.00 31.14  ? 324 HOH L O   1 
HETATM 6764 O O   . HOH J 5 .   ? 32.706  -11.495 33.948  1.00 21.27  ? 325 HOH L O   1 
HETATM 6765 O O   . HOH J 5 .   ? 29.811  -15.045 38.857  1.00 24.92  ? 326 HOH L O   1 
HETATM 6766 O O   . HOH J 5 .   ? 22.331  6.680   45.397  1.00 32.00  ? 327 HOH L O   1 
HETATM 6767 O O   . HOH J 5 .   ? 12.727  -19.116 36.644  1.00 27.97  ? 328 HOH L O   1 
HETATM 6768 O O   . HOH J 5 .   ? 34.826  1.435   44.241  1.00 30.94  ? 329 HOH L O   1 
HETATM 6769 O O   . HOH J 5 .   ? 30.071  -8.779  24.855  1.00 21.85  ? 330 HOH L O   1 
HETATM 6770 O O   . HOH J 5 .   ? 15.299  -9.252  44.603  1.00 25.10  ? 331 HOH L O   1 
HETATM 6771 O O   . HOH J 5 .   ? 29.685  2.480   64.570  1.00 23.12  ? 332 HOH L O   1 
HETATM 6772 O O   . HOH J 5 .   ? 29.031  -15.004 49.192  1.00 30.74  ? 333 HOH L O   1 
HETATM 6773 O O   . HOH J 5 .   ? 9.261   -18.595 37.037  1.00 43.38  ? 334 HOH L O   1 
HETATM 6774 O O   . HOH J 5 .   ? 26.672  6.695   58.174  1.00 28.48  ? 335 HOH L O   1 
HETATM 6775 O O   . HOH J 5 .   ? 14.475  -15.947 22.248  1.00 22.06  ? 336 HOH L O   1 
HETATM 6776 O O   . HOH J 5 .   ? 18.505  14.803  74.917  1.00 32.67  ? 337 HOH L O   1 
HETATM 6777 O O   . HOH J 5 .   ? 34.743  -9.370  29.972  1.00 25.30  ? 338 HOH L O   1 
HETATM 6778 O O   . HOH J 5 .   ? 11.443  -7.999  40.106  1.00 36.01  ? 339 HOH L O   1 
HETATM 6779 O O   . HOH J 5 .   ? 16.117  1.357   62.196  1.00 43.33  ? 340 HOH L O   1 
HETATM 6780 O O   . HOH J 5 .   ? 27.536  -11.254 60.134  1.00 38.62  ? 341 HOH L O   1 
HETATM 6781 O O   . HOH J 5 .   ? 26.514  -13.313 54.549  1.00 34.70  ? 342 HOH L O   1 
HETATM 6782 O O   . HOH J 5 .   ? 41.364  -7.019  50.317  1.00 33.57  ? 343 HOH L O   1 
HETATM 6783 O O   . HOH J 5 .   ? 31.737  4.379   42.962  1.00 29.06  ? 344 HOH L O   1 
HETATM 6784 O O   . HOH J 5 .   ? 11.733  -19.706 30.541  1.00 38.62  ? 345 HOH L O   1 
HETATM 6785 O O   . HOH J 5 .   ? 10.136  -3.148  36.827  1.00 33.58  ? 346 HOH L O   1 
HETATM 6786 O O   . HOH J 5 .   ? 32.785  0.806   71.887  1.00 39.42  ? 347 HOH L O   1 
HETATM 6787 O O   . HOH J 5 .   ? 21.806  4.648   47.079  1.00 34.84  ? 348 HOH L O   1 
HETATM 6788 O O   . HOH J 5 .   ? 27.518  -12.588 25.152  1.00 28.33  ? 349 HOH L O   1 
HETATM 6789 O O   . HOH J 5 .   ? 22.710  -22.835 30.969  1.00 37.22  ? 350 HOH L O   1 
HETATM 6790 O O   . HOH J 5 .   ? 2.719   -9.220  34.881  1.00 47.82  ? 351 HOH L O   1 
# 
