data_8Z94
# 
_entry.id   8Z94 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Z94         pdb_00008z94 10.2210/pdb8z94/pdb 
WWPDB D_1300047234 ?            ?                   
EMDB  EMD-39854    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-30 ? 
2 'EM metadata'     1 0 2025-04-30 ? 
3 FSC               1 0 2025-04-30 ? 
4 'Half map'        1 0 2025-04-30 1 
5 'Half map'        1 0 2025-04-30 2 
6 Image             1 0 2025-04-30 ? 
7 'Primary map'     1 0 2025-04-30 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Z94 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of RIPK1 RHIM PFFs cross seeded RIPK3 RHIM amyloid fibril' 
_pdbx_database_related.db_id          EMD-39854 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              liulab@sioc.ac.cn 
_pdbx_contact_author.name_first         Cong 
_pdbx_contact_author.name_last          Liu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3425-6672 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ma, Y.'   1 ? 
'Zhao, K.' 2 ? 
'Liu, C.'  3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM structure of RIPK1 RHIM PFFs cross seeded RIPK3 RHIM amyloid fibril' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Ma, Y.'   1 ? 
primary 'Zhao, K.' 2 ? 
primary 'Liu, C.'  3 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Receptor-interacting serine/threonine-protein kinase 3' 
_entity.formula_weight             15311.755 
_entity.pdbx_number_of_molecules   3 
_entity.pdbx_ec                    2.7.11.1 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'RIP-like protein kinase 3,Receptor-interacting protein 3,RIP-3' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNY
LTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGKLEHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNY
LTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGKLEHHHHHH
;
_entity_poly.pdbx_strand_id                 B,A,C 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   ASP n 
1 6   SER n 
1 7   MET n 
1 8   ALA n 
1 9   GLN n 
1 10  PRO n 
1 11  PRO n 
1 12  GLN n 
1 13  THR n 
1 14  PRO n 
1 15  GLU n 
1 16  THR n 
1 17  SER n 
1 18  THR n 
1 19  PHE n 
1 20  ARG n 
1 21  ASN n 
1 22  GLN n 
1 23  MET n 
1 24  PRO n 
1 25  SER n 
1 26  PRO n 
1 27  THR n 
1 28  SER n 
1 29  THR n 
1 30  GLY n 
1 31  THR n 
1 32  PRO n 
1 33  SER n 
1 34  PRO n 
1 35  GLY n 
1 36  PRO n 
1 37  ARG n 
1 38  GLY n 
1 39  ASN n 
1 40  GLN n 
1 41  GLY n 
1 42  ALA n 
1 43  GLU n 
1 44  ARG n 
1 45  GLN n 
1 46  GLY n 
1 47  MET n 
1 48  ASN n 
1 49  TRP n 
1 50  SER n 
1 51  CYS n 
1 52  ARG n 
1 53  THR n 
1 54  PRO n 
1 55  GLU n 
1 56  PRO n 
1 57  ASN n 
1 58  PRO n 
1 59  VAL n 
1 60  THR n 
1 61  GLY n 
1 62  ARG n 
1 63  PRO n 
1 64  LEU n 
1 65  VAL n 
1 66  ASN n 
1 67  ILE n 
1 68  TYR n 
1 69  ASN n 
1 70  CYS n 
1 71  SER n 
1 72  GLY n 
1 73  VAL n 
1 74  GLN n 
1 75  VAL n 
1 76  GLY n 
1 77  ASP n 
1 78  ASN n 
1 79  ASN n 
1 80  TYR n 
1 81  LEU n 
1 82  THR n 
1 83  MET n 
1 84  GLN n 
1 85  GLN n 
1 86  THR n 
1 87  THR n 
1 88  ALA n 
1 89  LEU n 
1 90  PRO n 
1 91  THR n 
1 92  TRP n 
1 93  GLY n 
1 94  LEU n 
1 95  ALA n 
1 96  PRO n 
1 97  SER n 
1 98  GLY n 
1 99  LYS n 
1 100 GLY n 
1 101 ARG n 
1 102 GLY n 
1 103 LEU n 
1 104 GLN n 
1 105 HIS n 
1 106 PRO n 
1 107 PRO n 
1 108 PRO n 
1 109 VAL n 
1 110 GLY n 
1 111 SER n 
1 112 GLN n 
1 113 GLU n 
1 114 GLY n 
1 115 PRO n 
1 116 LYS n 
1 117 ASP n 
1 118 PRO n 
1 119 GLU n 
1 120 ALA n 
1 121 TRP n 
1 122 SER n 
1 123 ARG n 
1 124 PRO n 
1 125 GLN n 
1 126 GLY n 
1 127 TRP n 
1 128 TYR n 
1 129 ASN n 
1 130 HIS n 
1 131 SER n 
1 132 GLY n 
1 133 LYS n 
1 134 LEU n 
1 135 GLU n 
1 136 HIS n 
1 137 HIS n 
1 138 HIS n 
1 139 HIS n 
1 140 HIS n 
1 141 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   141 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'RIPK3, RIP3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   386 ?   ?   ?   B . n 
A 1 2   GLY 2   387 ?   ?   ?   B . n 
A 1 3   SER 3   388 ?   ?   ?   B . n 
A 1 4   SER 4   389 ?   ?   ?   B . n 
A 1 5   ASP 5   390 ?   ?   ?   B . n 
A 1 6   SER 6   391 ?   ?   ?   B . n 
A 1 7   MET 7   392 ?   ?   ?   B . n 
A 1 8   ALA 8   393 ?   ?   ?   B . n 
A 1 9   GLN 9   394 ?   ?   ?   B . n 
A 1 10  PRO 10  395 ?   ?   ?   B . n 
A 1 11  PRO 11  396 ?   ?   ?   B . n 
A 1 12  GLN 12  397 ?   ?   ?   B . n 
A 1 13  THR 13  398 ?   ?   ?   B . n 
A 1 14  PRO 14  399 ?   ?   ?   B . n 
A 1 15  GLU 15  400 ?   ?   ?   B . n 
A 1 16  THR 16  401 ?   ?   ?   B . n 
A 1 17  SER 17  402 ?   ?   ?   B . n 
A 1 18  THR 18  403 ?   ?   ?   B . n 
A 1 19  PHE 19  404 ?   ?   ?   B . n 
A 1 20  ARG 20  405 ?   ?   ?   B . n 
A 1 21  ASN 21  406 ?   ?   ?   B . n 
A 1 22  GLN 22  407 ?   ?   ?   B . n 
A 1 23  MET 23  408 ?   ?   ?   B . n 
A 1 24  PRO 24  409 ?   ?   ?   B . n 
A 1 25  SER 25  410 ?   ?   ?   B . n 
A 1 26  PRO 26  411 ?   ?   ?   B . n 
A 1 27  THR 27  412 ?   ?   ?   B . n 
A 1 28  SER 28  413 ?   ?   ?   B . n 
A 1 29  THR 29  414 ?   ?   ?   B . n 
A 1 30  GLY 30  415 ?   ?   ?   B . n 
A 1 31  THR 31  416 ?   ?   ?   B . n 
A 1 32  PRO 32  417 ?   ?   ?   B . n 
A 1 33  SER 33  418 ?   ?   ?   B . n 
A 1 34  PRO 34  419 ?   ?   ?   B . n 
A 1 35  GLY 35  420 ?   ?   ?   B . n 
A 1 36  PRO 36  421 ?   ?   ?   B . n 
A 1 37  ARG 37  422 ?   ?   ?   B . n 
A 1 38  GLY 38  423 ?   ?   ?   B . n 
A 1 39  ASN 39  424 ?   ?   ?   B . n 
A 1 40  GLN 40  425 ?   ?   ?   B . n 
A 1 41  GLY 41  426 ?   ?   ?   B . n 
A 1 42  ALA 42  427 ?   ?   ?   B . n 
A 1 43  GLU 43  428 ?   ?   ?   B . n 
A 1 44  ARG 44  429 ?   ?   ?   B . n 
A 1 45  GLN 45  430 ?   ?   ?   B . n 
A 1 46  GLY 46  431 ?   ?   ?   B . n 
A 1 47  MET 47  432 ?   ?   ?   B . n 
A 1 48  ASN 48  433 ?   ?   ?   B . n 
A 1 49  TRP 49  434 ?   ?   ?   B . n 
A 1 50  SER 50  435 ?   ?   ?   B . n 
A 1 51  CYS 51  436 ?   ?   ?   B . n 
A 1 52  ARG 52  437 ?   ?   ?   B . n 
A 1 53  THR 53  438 ?   ?   ?   B . n 
A 1 54  PRO 54  439 ?   ?   ?   B . n 
A 1 55  GLU 55  440 ?   ?   ?   B . n 
A 1 56  PRO 56  441 ?   ?   ?   B . n 
A 1 57  ASN 57  442 ?   ?   ?   B . n 
A 1 58  PRO 58  443 ?   ?   ?   B . n 
A 1 59  VAL 59  444 ?   ?   ?   B . n 
A 1 60  THR 60  445 ?   ?   ?   B . n 
A 1 61  GLY 61  446 ?   ?   ?   B . n 
A 1 62  ARG 62  447 ?   ?   ?   B . n 
A 1 63  PRO 63  448 448 PRO PRO B . n 
A 1 64  LEU 64  449 449 LEU LEU B . n 
A 1 65  VAL 65  450 450 VAL VAL B . n 
A 1 66  ASN 66  451 451 ASN ASN B . n 
A 1 67  ILE 67  452 452 ILE ILE B . n 
A 1 68  TYR 68  453 453 TYR TYR B . n 
A 1 69  ASN 69  454 454 ASN ASN B . n 
A 1 70  CYS 70  455 455 CYS CYS B . n 
A 1 71  SER 71  456 456 SER SER B . n 
A 1 72  GLY 72  457 457 GLY GLY B . n 
A 1 73  VAL 73  458 458 VAL VAL B . n 
A 1 74  GLN 74  459 459 GLN GLN B . n 
A 1 75  VAL 75  460 460 VAL VAL B . n 
A 1 76  GLY 76  461 461 GLY GLY B . n 
A 1 77  ASP 77  462 462 ASP ASP B . n 
A 1 78  ASN 78  463 463 ASN ASN B . n 
A 1 79  ASN 79  464 464 ASN ASN B . n 
A 1 80  TYR 80  465 465 TYR TYR B . n 
A 1 81  LEU 81  466 466 LEU LEU B . n 
A 1 82  THR 82  467 467 THR THR B . n 
A 1 83  MET 83  468 468 MET MET B . n 
A 1 84  GLN 84  469 469 GLN GLN B . n 
A 1 85  GLN 85  470 ?   ?   ?   B . n 
A 1 86  THR 86  471 ?   ?   ?   B . n 
A 1 87  THR 87  472 ?   ?   ?   B . n 
A 1 88  ALA 88  473 ?   ?   ?   B . n 
A 1 89  LEU 89  474 ?   ?   ?   B . n 
A 1 90  PRO 90  475 ?   ?   ?   B . n 
A 1 91  THR 91  476 ?   ?   ?   B . n 
A 1 92  TRP 92  477 ?   ?   ?   B . n 
A 1 93  GLY 93  478 ?   ?   ?   B . n 
A 1 94  LEU 94  479 ?   ?   ?   B . n 
A 1 95  ALA 95  480 ?   ?   ?   B . n 
A 1 96  PRO 96  481 ?   ?   ?   B . n 
A 1 97  SER 97  482 ?   ?   ?   B . n 
A 1 98  GLY 98  483 ?   ?   ?   B . n 
A 1 99  LYS 99  484 ?   ?   ?   B . n 
A 1 100 GLY 100 485 ?   ?   ?   B . n 
A 1 101 ARG 101 486 ?   ?   ?   B . n 
A 1 102 GLY 102 487 ?   ?   ?   B . n 
A 1 103 LEU 103 488 ?   ?   ?   B . n 
A 1 104 GLN 104 489 ?   ?   ?   B . n 
A 1 105 HIS 105 490 ?   ?   ?   B . n 
A 1 106 PRO 106 491 ?   ?   ?   B . n 
A 1 107 PRO 107 492 ?   ?   ?   B . n 
A 1 108 PRO 108 493 ?   ?   ?   B . n 
A 1 109 VAL 109 494 ?   ?   ?   B . n 
A 1 110 GLY 110 495 ?   ?   ?   B . n 
A 1 111 SER 111 496 ?   ?   ?   B . n 
A 1 112 GLN 112 497 ?   ?   ?   B . n 
A 1 113 GLU 113 498 ?   ?   ?   B . n 
A 1 114 GLY 114 499 ?   ?   ?   B . n 
A 1 115 PRO 115 500 ?   ?   ?   B . n 
A 1 116 LYS 116 501 ?   ?   ?   B . n 
A 1 117 ASP 117 502 ?   ?   ?   B . n 
A 1 118 PRO 118 503 ?   ?   ?   B . n 
A 1 119 GLU 119 504 ?   ?   ?   B . n 
A 1 120 ALA 120 505 ?   ?   ?   B . n 
A 1 121 TRP 121 506 ?   ?   ?   B . n 
A 1 122 SER 122 507 ?   ?   ?   B . n 
A 1 123 ARG 123 508 ?   ?   ?   B . n 
A 1 124 PRO 124 509 ?   ?   ?   B . n 
A 1 125 GLN 125 510 ?   ?   ?   B . n 
A 1 126 GLY 126 511 ?   ?   ?   B . n 
A 1 127 TRP 127 512 ?   ?   ?   B . n 
A 1 128 TYR 128 513 ?   ?   ?   B . n 
A 1 129 ASN 129 514 ?   ?   ?   B . n 
A 1 130 HIS 130 515 ?   ?   ?   B . n 
A 1 131 SER 131 516 ?   ?   ?   B . n 
A 1 132 GLY 132 517 ?   ?   ?   B . n 
A 1 133 LYS 133 518 ?   ?   ?   B . n 
A 1 134 LEU 134 519 ?   ?   ?   B . n 
A 1 135 GLU 135 520 ?   ?   ?   B . n 
A 1 136 HIS 136 521 ?   ?   ?   B . n 
A 1 137 HIS 137 522 ?   ?   ?   B . n 
A 1 138 HIS 138 523 ?   ?   ?   B . n 
A 1 139 HIS 139 524 ?   ?   ?   B . n 
A 1 140 HIS 140 525 ?   ?   ?   B . n 
A 1 141 HIS 141 526 ?   ?   ?   B . n 
B 1 1   MET 1   386 ?   ?   ?   A . n 
B 1 2   GLY 2   387 ?   ?   ?   A . n 
B 1 3   SER 3   388 ?   ?   ?   A . n 
B 1 4   SER 4   389 ?   ?   ?   A . n 
B 1 5   ASP 5   390 ?   ?   ?   A . n 
B 1 6   SER 6   391 ?   ?   ?   A . n 
B 1 7   MET 7   392 ?   ?   ?   A . n 
B 1 8   ALA 8   393 ?   ?   ?   A . n 
B 1 9   GLN 9   394 ?   ?   ?   A . n 
B 1 10  PRO 10  395 ?   ?   ?   A . n 
B 1 11  PRO 11  396 ?   ?   ?   A . n 
B 1 12  GLN 12  397 ?   ?   ?   A . n 
B 1 13  THR 13  398 ?   ?   ?   A . n 
B 1 14  PRO 14  399 ?   ?   ?   A . n 
B 1 15  GLU 15  400 ?   ?   ?   A . n 
B 1 16  THR 16  401 ?   ?   ?   A . n 
B 1 17  SER 17  402 ?   ?   ?   A . n 
B 1 18  THR 18  403 ?   ?   ?   A . n 
B 1 19  PHE 19  404 ?   ?   ?   A . n 
B 1 20  ARG 20  405 ?   ?   ?   A . n 
B 1 21  ASN 21  406 ?   ?   ?   A . n 
B 1 22  GLN 22  407 ?   ?   ?   A . n 
B 1 23  MET 23  408 ?   ?   ?   A . n 
B 1 24  PRO 24  409 ?   ?   ?   A . n 
B 1 25  SER 25  410 ?   ?   ?   A . n 
B 1 26  PRO 26  411 ?   ?   ?   A . n 
B 1 27  THR 27  412 ?   ?   ?   A . n 
B 1 28  SER 28  413 ?   ?   ?   A . n 
B 1 29  THR 29  414 ?   ?   ?   A . n 
B 1 30  GLY 30  415 ?   ?   ?   A . n 
B 1 31  THR 31  416 ?   ?   ?   A . n 
B 1 32  PRO 32  417 ?   ?   ?   A . n 
B 1 33  SER 33  418 ?   ?   ?   A . n 
B 1 34  PRO 34  419 ?   ?   ?   A . n 
B 1 35  GLY 35  420 ?   ?   ?   A . n 
B 1 36  PRO 36  421 ?   ?   ?   A . n 
B 1 37  ARG 37  422 ?   ?   ?   A . n 
B 1 38  GLY 38  423 ?   ?   ?   A . n 
B 1 39  ASN 39  424 ?   ?   ?   A . n 
B 1 40  GLN 40  425 ?   ?   ?   A . n 
B 1 41  GLY 41  426 ?   ?   ?   A . n 
B 1 42  ALA 42  427 ?   ?   ?   A . n 
B 1 43  GLU 43  428 ?   ?   ?   A . n 
B 1 44  ARG 44  429 ?   ?   ?   A . n 
B 1 45  GLN 45  430 ?   ?   ?   A . n 
B 1 46  GLY 46  431 ?   ?   ?   A . n 
B 1 47  MET 47  432 ?   ?   ?   A . n 
B 1 48  ASN 48  433 ?   ?   ?   A . n 
B 1 49  TRP 49  434 ?   ?   ?   A . n 
B 1 50  SER 50  435 ?   ?   ?   A . n 
B 1 51  CYS 51  436 ?   ?   ?   A . n 
B 1 52  ARG 52  437 ?   ?   ?   A . n 
B 1 53  THR 53  438 ?   ?   ?   A . n 
B 1 54  PRO 54  439 ?   ?   ?   A . n 
B 1 55  GLU 55  440 ?   ?   ?   A . n 
B 1 56  PRO 56  441 ?   ?   ?   A . n 
B 1 57  ASN 57  442 ?   ?   ?   A . n 
B 1 58  PRO 58  443 ?   ?   ?   A . n 
B 1 59  VAL 59  444 ?   ?   ?   A . n 
B 1 60  THR 60  445 ?   ?   ?   A . n 
B 1 61  GLY 61  446 ?   ?   ?   A . n 
B 1 62  ARG 62  447 ?   ?   ?   A . n 
B 1 63  PRO 63  448 448 PRO PRO A . n 
B 1 64  LEU 64  449 449 LEU LEU A . n 
B 1 65  VAL 65  450 450 VAL VAL A . n 
B 1 66  ASN 66  451 451 ASN ASN A . n 
B 1 67  ILE 67  452 452 ILE ILE A . n 
B 1 68  TYR 68  453 453 TYR TYR A . n 
B 1 69  ASN 69  454 454 ASN ASN A . n 
B 1 70  CYS 70  455 455 CYS CYS A . n 
B 1 71  SER 71  456 456 SER SER A . n 
B 1 72  GLY 72  457 457 GLY GLY A . n 
B 1 73  VAL 73  458 458 VAL VAL A . n 
B 1 74  GLN 74  459 459 GLN GLN A . n 
B 1 75  VAL 75  460 460 VAL VAL A . n 
B 1 76  GLY 76  461 461 GLY GLY A . n 
B 1 77  ASP 77  462 462 ASP ASP A . n 
B 1 78  ASN 78  463 463 ASN ASN A . n 
B 1 79  ASN 79  464 464 ASN ASN A . n 
B 1 80  TYR 80  465 465 TYR TYR A . n 
B 1 81  LEU 81  466 466 LEU LEU A . n 
B 1 82  THR 82  467 467 THR THR A . n 
B 1 83  MET 83  468 468 MET MET A . n 
B 1 84  GLN 84  469 469 GLN GLN A . n 
B 1 85  GLN 85  470 ?   ?   ?   A . n 
B 1 86  THR 86  471 ?   ?   ?   A . n 
B 1 87  THR 87  472 ?   ?   ?   A . n 
B 1 88  ALA 88  473 ?   ?   ?   A . n 
B 1 89  LEU 89  474 ?   ?   ?   A . n 
B 1 90  PRO 90  475 ?   ?   ?   A . n 
B 1 91  THR 91  476 ?   ?   ?   A . n 
B 1 92  TRP 92  477 ?   ?   ?   A . n 
B 1 93  GLY 93  478 ?   ?   ?   A . n 
B 1 94  LEU 94  479 ?   ?   ?   A . n 
B 1 95  ALA 95  480 ?   ?   ?   A . n 
B 1 96  PRO 96  481 ?   ?   ?   A . n 
B 1 97  SER 97  482 ?   ?   ?   A . n 
B 1 98  GLY 98  483 ?   ?   ?   A . n 
B 1 99  LYS 99  484 ?   ?   ?   A . n 
B 1 100 GLY 100 485 ?   ?   ?   A . n 
B 1 101 ARG 101 486 ?   ?   ?   A . n 
B 1 102 GLY 102 487 ?   ?   ?   A . n 
B 1 103 LEU 103 488 ?   ?   ?   A . n 
B 1 104 GLN 104 489 ?   ?   ?   A . n 
B 1 105 HIS 105 490 ?   ?   ?   A . n 
B 1 106 PRO 106 491 ?   ?   ?   A . n 
B 1 107 PRO 107 492 ?   ?   ?   A . n 
B 1 108 PRO 108 493 ?   ?   ?   A . n 
B 1 109 VAL 109 494 ?   ?   ?   A . n 
B 1 110 GLY 110 495 ?   ?   ?   A . n 
B 1 111 SER 111 496 ?   ?   ?   A . n 
B 1 112 GLN 112 497 ?   ?   ?   A . n 
B 1 113 GLU 113 498 ?   ?   ?   A . n 
B 1 114 GLY 114 499 ?   ?   ?   A . n 
B 1 115 PRO 115 500 ?   ?   ?   A . n 
B 1 116 LYS 116 501 ?   ?   ?   A . n 
B 1 117 ASP 117 502 ?   ?   ?   A . n 
B 1 118 PRO 118 503 ?   ?   ?   A . n 
B 1 119 GLU 119 504 ?   ?   ?   A . n 
B 1 120 ALA 120 505 ?   ?   ?   A . n 
B 1 121 TRP 121 506 ?   ?   ?   A . n 
B 1 122 SER 122 507 ?   ?   ?   A . n 
B 1 123 ARG 123 508 ?   ?   ?   A . n 
B 1 124 PRO 124 509 ?   ?   ?   A . n 
B 1 125 GLN 125 510 ?   ?   ?   A . n 
B 1 126 GLY 126 511 ?   ?   ?   A . n 
B 1 127 TRP 127 512 ?   ?   ?   A . n 
B 1 128 TYR 128 513 ?   ?   ?   A . n 
B 1 129 ASN 129 514 ?   ?   ?   A . n 
B 1 130 HIS 130 515 ?   ?   ?   A . n 
B 1 131 SER 131 516 ?   ?   ?   A . n 
B 1 132 GLY 132 517 ?   ?   ?   A . n 
B 1 133 LYS 133 518 ?   ?   ?   A . n 
B 1 134 LEU 134 519 ?   ?   ?   A . n 
B 1 135 GLU 135 520 ?   ?   ?   A . n 
B 1 136 HIS 136 521 ?   ?   ?   A . n 
B 1 137 HIS 137 522 ?   ?   ?   A . n 
B 1 138 HIS 138 523 ?   ?   ?   A . n 
B 1 139 HIS 139 524 ?   ?   ?   A . n 
B 1 140 HIS 140 525 ?   ?   ?   A . n 
B 1 141 HIS 141 526 ?   ?   ?   A . n 
C 1 1   MET 1   386 ?   ?   ?   C . n 
C 1 2   GLY 2   387 ?   ?   ?   C . n 
C 1 3   SER 3   388 ?   ?   ?   C . n 
C 1 4   SER 4   389 ?   ?   ?   C . n 
C 1 5   ASP 5   390 ?   ?   ?   C . n 
C 1 6   SER 6   391 ?   ?   ?   C . n 
C 1 7   MET 7   392 ?   ?   ?   C . n 
C 1 8   ALA 8   393 ?   ?   ?   C . n 
C 1 9   GLN 9   394 ?   ?   ?   C . n 
C 1 10  PRO 10  395 ?   ?   ?   C . n 
C 1 11  PRO 11  396 ?   ?   ?   C . n 
C 1 12  GLN 12  397 ?   ?   ?   C . n 
C 1 13  THR 13  398 ?   ?   ?   C . n 
C 1 14  PRO 14  399 ?   ?   ?   C . n 
C 1 15  GLU 15  400 ?   ?   ?   C . n 
C 1 16  THR 16  401 ?   ?   ?   C . n 
C 1 17  SER 17  402 ?   ?   ?   C . n 
C 1 18  THR 18  403 ?   ?   ?   C . n 
C 1 19  PHE 19  404 ?   ?   ?   C . n 
C 1 20  ARG 20  405 ?   ?   ?   C . n 
C 1 21  ASN 21  406 ?   ?   ?   C . n 
C 1 22  GLN 22  407 ?   ?   ?   C . n 
C 1 23  MET 23  408 ?   ?   ?   C . n 
C 1 24  PRO 24  409 ?   ?   ?   C . n 
C 1 25  SER 25  410 ?   ?   ?   C . n 
C 1 26  PRO 26  411 ?   ?   ?   C . n 
C 1 27  THR 27  412 ?   ?   ?   C . n 
C 1 28  SER 28  413 ?   ?   ?   C . n 
C 1 29  THR 29  414 ?   ?   ?   C . n 
C 1 30  GLY 30  415 ?   ?   ?   C . n 
C 1 31  THR 31  416 ?   ?   ?   C . n 
C 1 32  PRO 32  417 ?   ?   ?   C . n 
C 1 33  SER 33  418 ?   ?   ?   C . n 
C 1 34  PRO 34  419 ?   ?   ?   C . n 
C 1 35  GLY 35  420 ?   ?   ?   C . n 
C 1 36  PRO 36  421 ?   ?   ?   C . n 
C 1 37  ARG 37  422 ?   ?   ?   C . n 
C 1 38  GLY 38  423 ?   ?   ?   C . n 
C 1 39  ASN 39  424 ?   ?   ?   C . n 
C 1 40  GLN 40  425 ?   ?   ?   C . n 
C 1 41  GLY 41  426 ?   ?   ?   C . n 
C 1 42  ALA 42  427 ?   ?   ?   C . n 
C 1 43  GLU 43  428 ?   ?   ?   C . n 
C 1 44  ARG 44  429 ?   ?   ?   C . n 
C 1 45  GLN 45  430 ?   ?   ?   C . n 
C 1 46  GLY 46  431 ?   ?   ?   C . n 
C 1 47  MET 47  432 ?   ?   ?   C . n 
C 1 48  ASN 48  433 ?   ?   ?   C . n 
C 1 49  TRP 49  434 ?   ?   ?   C . n 
C 1 50  SER 50  435 ?   ?   ?   C . n 
C 1 51  CYS 51  436 ?   ?   ?   C . n 
C 1 52  ARG 52  437 ?   ?   ?   C . n 
C 1 53  THR 53  438 ?   ?   ?   C . n 
C 1 54  PRO 54  439 ?   ?   ?   C . n 
C 1 55  GLU 55  440 ?   ?   ?   C . n 
C 1 56  PRO 56  441 ?   ?   ?   C . n 
C 1 57  ASN 57  442 ?   ?   ?   C . n 
C 1 58  PRO 58  443 ?   ?   ?   C . n 
C 1 59  VAL 59  444 ?   ?   ?   C . n 
C 1 60  THR 60  445 ?   ?   ?   C . n 
C 1 61  GLY 61  446 ?   ?   ?   C . n 
C 1 62  ARG 62  447 ?   ?   ?   C . n 
C 1 63  PRO 63  448 448 PRO PRO C . n 
C 1 64  LEU 64  449 449 LEU LEU C . n 
C 1 65  VAL 65  450 450 VAL VAL C . n 
C 1 66  ASN 66  451 451 ASN ASN C . n 
C 1 67  ILE 67  452 452 ILE ILE C . n 
C 1 68  TYR 68  453 453 TYR TYR C . n 
C 1 69  ASN 69  454 454 ASN ASN C . n 
C 1 70  CYS 70  455 455 CYS CYS C . n 
C 1 71  SER 71  456 456 SER SER C . n 
C 1 72  GLY 72  457 457 GLY GLY C . n 
C 1 73  VAL 73  458 458 VAL VAL C . n 
C 1 74  GLN 74  459 459 GLN GLN C . n 
C 1 75  VAL 75  460 460 VAL VAL C . n 
C 1 76  GLY 76  461 461 GLY GLY C . n 
C 1 77  ASP 77  462 462 ASP ASP C . n 
C 1 78  ASN 78  463 463 ASN ASN C . n 
C 1 79  ASN 79  464 464 ASN ASN C . n 
C 1 80  TYR 80  465 465 TYR TYR C . n 
C 1 81  LEU 81  466 466 LEU LEU C . n 
C 1 82  THR 82  467 467 THR THR C . n 
C 1 83  MET 83  468 468 MET MET C . n 
C 1 84  GLN 84  469 469 GLN GLN C . n 
C 1 85  GLN 85  470 ?   ?   ?   C . n 
C 1 86  THR 86  471 ?   ?   ?   C . n 
C 1 87  THR 87  472 ?   ?   ?   C . n 
C 1 88  ALA 88  473 ?   ?   ?   C . n 
C 1 89  LEU 89  474 ?   ?   ?   C . n 
C 1 90  PRO 90  475 ?   ?   ?   C . n 
C 1 91  THR 91  476 ?   ?   ?   C . n 
C 1 92  TRP 92  477 ?   ?   ?   C . n 
C 1 93  GLY 93  478 ?   ?   ?   C . n 
C 1 94  LEU 94  479 ?   ?   ?   C . n 
C 1 95  ALA 95  480 ?   ?   ?   C . n 
C 1 96  PRO 96  481 ?   ?   ?   C . n 
C 1 97  SER 97  482 ?   ?   ?   C . n 
C 1 98  GLY 98  483 ?   ?   ?   C . n 
C 1 99  LYS 99  484 ?   ?   ?   C . n 
C 1 100 GLY 100 485 ?   ?   ?   C . n 
C 1 101 ARG 101 486 ?   ?   ?   C . n 
C 1 102 GLY 102 487 ?   ?   ?   C . n 
C 1 103 LEU 103 488 ?   ?   ?   C . n 
C 1 104 GLN 104 489 ?   ?   ?   C . n 
C 1 105 HIS 105 490 ?   ?   ?   C . n 
C 1 106 PRO 106 491 ?   ?   ?   C . n 
C 1 107 PRO 107 492 ?   ?   ?   C . n 
C 1 108 PRO 108 493 ?   ?   ?   C . n 
C 1 109 VAL 109 494 ?   ?   ?   C . n 
C 1 110 GLY 110 495 ?   ?   ?   C . n 
C 1 111 SER 111 496 ?   ?   ?   C . n 
C 1 112 GLN 112 497 ?   ?   ?   C . n 
C 1 113 GLU 113 498 ?   ?   ?   C . n 
C 1 114 GLY 114 499 ?   ?   ?   C . n 
C 1 115 PRO 115 500 ?   ?   ?   C . n 
C 1 116 LYS 116 501 ?   ?   ?   C . n 
C 1 117 ASP 117 502 ?   ?   ?   C . n 
C 1 118 PRO 118 503 ?   ?   ?   C . n 
C 1 119 GLU 119 504 ?   ?   ?   C . n 
C 1 120 ALA 120 505 ?   ?   ?   C . n 
C 1 121 TRP 121 506 ?   ?   ?   C . n 
C 1 122 SER 122 507 ?   ?   ?   C . n 
C 1 123 ARG 123 508 ?   ?   ?   C . n 
C 1 124 PRO 124 509 ?   ?   ?   C . n 
C 1 125 GLN 125 510 ?   ?   ?   C . n 
C 1 126 GLY 126 511 ?   ?   ?   C . n 
C 1 127 TRP 127 512 ?   ?   ?   C . n 
C 1 128 TYR 128 513 ?   ?   ?   C . n 
C 1 129 ASN 129 514 ?   ?   ?   C . n 
C 1 130 HIS 130 515 ?   ?   ?   C . n 
C 1 131 SER 131 516 ?   ?   ?   C . n 
C 1 132 GLY 132 517 ?   ?   ?   C . n 
C 1 133 LYS 133 518 ?   ?   ?   C . n 
C 1 134 LEU 134 519 ?   ?   ?   C . n 
C 1 135 GLU 135 520 ?   ?   ?   C . n 
C 1 136 HIS 136 521 ?   ?   ?   C . n 
C 1 137 HIS 137 522 ?   ?   ?   C . n 
C 1 138 HIS 138 523 ?   ?   ?   C . n 
C 1 139 HIS 139 524 ?   ?   ?   C . n 
C 1 140 HIS 140 525 ?   ?   ?   C . n 
C 1 141 HIS 141 526 ?   ?   ?   C . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Z94 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Z94 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Z94 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8Z94 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.011  ? 513 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 1.420  ? 696 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 11.704 ? 303 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.066  ? 81  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.008  ? 90  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8Z94 
_struct.title                        'Cryo-EM structure of RIPK1 RHIM PFFs cross seeded RIPK3 RHIM amyloid fibril' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Z94 
_struct_keywords.text            'amyloid fibril, PROTEIN FIBRIL' 
_struct_keywords.pdbx_keywords   'PROTEIN FIBRIL' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    RIPK3_HUMAN 
_struct_ref.pdbx_db_accession          Q9Y572 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLT
MQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
;
_struct_ref.pdbx_align_begin           388 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8Z94 B 3 ? 133 ? Q9Y572 388 ? 518 ? 388 518 
2 1 8Z94 A 3 ? 133 ? Q9Y572 388 ? 518 ? 388 518 
3 1 8Z94 C 3 ? 133 ? Q9Y572 388 ? 518 ? 388 518 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8Z94 MET B 1   ? UNP Q9Y572 ? ? 'initiating methionine' 386 1  
1 8Z94 GLY B 2   ? UNP Q9Y572 ? ? 'expression tag'        387 2  
1 8Z94 LEU B 134 ? UNP Q9Y572 ? ? 'expression tag'        519 3  
1 8Z94 GLU B 135 ? UNP Q9Y572 ? ? 'expression tag'        520 4  
1 8Z94 HIS B 136 ? UNP Q9Y572 ? ? 'expression tag'        521 5  
1 8Z94 HIS B 137 ? UNP Q9Y572 ? ? 'expression tag'        522 6  
1 8Z94 HIS B 138 ? UNP Q9Y572 ? ? 'expression tag'        523 7  
1 8Z94 HIS B 139 ? UNP Q9Y572 ? ? 'expression tag'        524 8  
1 8Z94 HIS B 140 ? UNP Q9Y572 ? ? 'expression tag'        525 9  
1 8Z94 HIS B 141 ? UNP Q9Y572 ? ? 'expression tag'        526 10 
2 8Z94 MET A 1   ? UNP Q9Y572 ? ? 'initiating methionine' 386 11 
2 8Z94 GLY A 2   ? UNP Q9Y572 ? ? 'expression tag'        387 12 
2 8Z94 LEU A 134 ? UNP Q9Y572 ? ? 'expression tag'        519 13 
2 8Z94 GLU A 135 ? UNP Q9Y572 ? ? 'expression tag'        520 14 
2 8Z94 HIS A 136 ? UNP Q9Y572 ? ? 'expression tag'        521 15 
2 8Z94 HIS A 137 ? UNP Q9Y572 ? ? 'expression tag'        522 16 
2 8Z94 HIS A 138 ? UNP Q9Y572 ? ? 'expression tag'        523 17 
2 8Z94 HIS A 139 ? UNP Q9Y572 ? ? 'expression tag'        524 18 
2 8Z94 HIS A 140 ? UNP Q9Y572 ? ? 'expression tag'        525 19 
2 8Z94 HIS A 141 ? UNP Q9Y572 ? ? 'expression tag'        526 20 
3 8Z94 MET C 1   ? UNP Q9Y572 ? ? 'initiating methionine' 386 21 
3 8Z94 GLY C 2   ? UNP Q9Y572 ? ? 'expression tag'        387 22 
3 8Z94 LEU C 134 ? UNP Q9Y572 ? ? 'expression tag'        519 23 
3 8Z94 GLU C 135 ? UNP Q9Y572 ? ? 'expression tag'        520 24 
3 8Z94 HIS C 136 ? UNP Q9Y572 ? ? 'expression tag'        521 25 
3 8Z94 HIS C 137 ? UNP Q9Y572 ? ? 'expression tag'        522 26 
3 8Z94 HIS C 138 ? UNP Q9Y572 ? ? 'expression tag'        523 27 
3 8Z94 HIS C 139 ? UNP Q9Y572 ? ? 'expression tag'        524 28 
3 8Z94 HIS C 140 ? UNP Q9Y572 ? ? 'expression tag'        525 29 
3 8Z94 HIS C 141 ? UNP Q9Y572 ? ? 'expression tag'        526 30 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
_pdbx_entry_details.entry_id                   8Z94 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   N 
_pdbx_validate_close_contact.auth_asym_id_1   B 
_pdbx_validate_close_contact.auth_comp_id_1   TYR 
_pdbx_validate_close_contact.auth_seq_id_1    453 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   C 
_pdbx_validate_close_contact.auth_comp_id_2   ILE 
_pdbx_validate_close_contact.auth_seq_id_2    452 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.13 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN B 451 ? ? 60.05   60.40   
2  1 ASN B 454 ? ? -79.28  -164.47 
3  1 SER B 456 ? ? -171.00 -171.28 
4  1 ASP B 462 ? ? -172.79 -168.30 
5  1 ASN A 451 ? ? 60.08   60.37   
6  1 ASN A 454 ? ? -79.36  -164.44 
7  1 SER A 456 ? ? -170.96 -171.20 
8  1 ASP A 462 ? ? -172.79 -168.26 
9  1 ASN C 451 ? ? 60.01   60.33   
10 1 ASN C 454 ? ? -79.34  -164.48 
11 1 SER C 456 ? ? -170.94 -171.23 
12 1 ASP C 462 ? ? -172.78 -168.22 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8Z94 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8Z94 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  4.56 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               45526 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               HELICAL 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            5.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 'ORGANELLE OR CELLULAR COMPONENT' 
_em_entity_assembly.name                 'RIPK1 RHIM PFFs cross seeded human RIPK3 RHIM fibril' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8Z94 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1300 
_em_imaging.nominal_defocus_max             2300 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8Z94 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8Z94 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   HELICAL 
_em_experiment.aggregation_state       'HELICAL ARRAY' 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 B MET 386 ? A MET 1   
2   1 Y 1 B GLY 387 ? A GLY 2   
3   1 Y 1 B SER 388 ? A SER 3   
4   1 Y 1 B SER 389 ? A SER 4   
5   1 Y 1 B ASP 390 ? A ASP 5   
6   1 Y 1 B SER 391 ? A SER 6   
7   1 Y 1 B MET 392 ? A MET 7   
8   1 Y 1 B ALA 393 ? A ALA 8   
9   1 Y 1 B GLN 394 ? A GLN 9   
10  1 Y 1 B PRO 395 ? A PRO 10  
11  1 Y 1 B PRO 396 ? A PRO 11  
12  1 Y 1 B GLN 397 ? A GLN 12  
13  1 Y 1 B THR 398 ? A THR 13  
14  1 Y 1 B PRO 399 ? A PRO 14  
15  1 Y 1 B GLU 400 ? A GLU 15  
16  1 Y 1 B THR 401 ? A THR 16  
17  1 Y 1 B SER 402 ? A SER 17  
18  1 Y 1 B THR 403 ? A THR 18  
19  1 Y 1 B PHE 404 ? A PHE 19  
20  1 Y 1 B ARG 405 ? A ARG 20  
21  1 Y 1 B ASN 406 ? A ASN 21  
22  1 Y 1 B GLN 407 ? A GLN 22  
23  1 Y 1 B MET 408 ? A MET 23  
24  1 Y 1 B PRO 409 ? A PRO 24  
25  1 Y 1 B SER 410 ? A SER 25  
26  1 Y 1 B PRO 411 ? A PRO 26  
27  1 Y 1 B THR 412 ? A THR 27  
28  1 Y 1 B SER 413 ? A SER 28  
29  1 Y 1 B THR 414 ? A THR 29  
30  1 Y 1 B GLY 415 ? A GLY 30  
31  1 Y 1 B THR 416 ? A THR 31  
32  1 Y 1 B PRO 417 ? A PRO 32  
33  1 Y 1 B SER 418 ? A SER 33  
34  1 Y 1 B PRO 419 ? A PRO 34  
35  1 Y 1 B GLY 420 ? A GLY 35  
36  1 Y 1 B PRO 421 ? A PRO 36  
37  1 Y 1 B ARG 422 ? A ARG 37  
38  1 Y 1 B GLY 423 ? A GLY 38  
39  1 Y 1 B ASN 424 ? A ASN 39  
40  1 Y 1 B GLN 425 ? A GLN 40  
41  1 Y 1 B GLY 426 ? A GLY 41  
42  1 Y 1 B ALA 427 ? A ALA 42  
43  1 Y 1 B GLU 428 ? A GLU 43  
44  1 Y 1 B ARG 429 ? A ARG 44  
45  1 Y 1 B GLN 430 ? A GLN 45  
46  1 Y 1 B GLY 431 ? A GLY 46  
47  1 Y 1 B MET 432 ? A MET 47  
48  1 Y 1 B ASN 433 ? A ASN 48  
49  1 Y 1 B TRP 434 ? A TRP 49  
50  1 Y 1 B SER 435 ? A SER 50  
51  1 Y 1 B CYS 436 ? A CYS 51  
52  1 Y 1 B ARG 437 ? A ARG 52  
53  1 Y 1 B THR 438 ? A THR 53  
54  1 Y 1 B PRO 439 ? A PRO 54  
55  1 Y 1 B GLU 440 ? A GLU 55  
56  1 Y 1 B PRO 441 ? A PRO 56  
57  1 Y 1 B ASN 442 ? A ASN 57  
58  1 Y 1 B PRO 443 ? A PRO 58  
59  1 Y 1 B VAL 444 ? A VAL 59  
60  1 Y 1 B THR 445 ? A THR 60  
61  1 Y 1 B GLY 446 ? A GLY 61  
62  1 Y 1 B ARG 447 ? A ARG 62  
63  1 Y 1 B GLN 470 ? A GLN 85  
64  1 Y 1 B THR 471 ? A THR 86  
65  1 Y 1 B THR 472 ? A THR 87  
66  1 Y 1 B ALA 473 ? A ALA 88  
67  1 Y 1 B LEU 474 ? A LEU 89  
68  1 Y 1 B PRO 475 ? A PRO 90  
69  1 Y 1 B THR 476 ? A THR 91  
70  1 Y 1 B TRP 477 ? A TRP 92  
71  1 Y 1 B GLY 478 ? A GLY 93  
72  1 Y 1 B LEU 479 ? A LEU 94  
73  1 Y 1 B ALA 480 ? A ALA 95  
74  1 Y 1 B PRO 481 ? A PRO 96  
75  1 Y 1 B SER 482 ? A SER 97  
76  1 Y 1 B GLY 483 ? A GLY 98  
77  1 Y 1 B LYS 484 ? A LYS 99  
78  1 Y 1 B GLY 485 ? A GLY 100 
79  1 Y 1 B ARG 486 ? A ARG 101 
80  1 Y 1 B GLY 487 ? A GLY 102 
81  1 Y 1 B LEU 488 ? A LEU 103 
82  1 Y 1 B GLN 489 ? A GLN 104 
83  1 Y 1 B HIS 490 ? A HIS 105 
84  1 Y 1 B PRO 491 ? A PRO 106 
85  1 Y 1 B PRO 492 ? A PRO 107 
86  1 Y 1 B PRO 493 ? A PRO 108 
87  1 Y 1 B VAL 494 ? A VAL 109 
88  1 Y 1 B GLY 495 ? A GLY 110 
89  1 Y 1 B SER 496 ? A SER 111 
90  1 Y 1 B GLN 497 ? A GLN 112 
91  1 Y 1 B GLU 498 ? A GLU 113 
92  1 Y 1 B GLY 499 ? A GLY 114 
93  1 Y 1 B PRO 500 ? A PRO 115 
94  1 Y 1 B LYS 501 ? A LYS 116 
95  1 Y 1 B ASP 502 ? A ASP 117 
96  1 Y 1 B PRO 503 ? A PRO 118 
97  1 Y 1 B GLU 504 ? A GLU 119 
98  1 Y 1 B ALA 505 ? A ALA 120 
99  1 Y 1 B TRP 506 ? A TRP 121 
100 1 Y 1 B SER 507 ? A SER 122 
101 1 Y 1 B ARG 508 ? A ARG 123 
102 1 Y 1 B PRO 509 ? A PRO 124 
103 1 Y 1 B GLN 510 ? A GLN 125 
104 1 Y 1 B GLY 511 ? A GLY 126 
105 1 Y 1 B TRP 512 ? A TRP 127 
106 1 Y 1 B TYR 513 ? A TYR 128 
107 1 Y 1 B ASN 514 ? A ASN 129 
108 1 Y 1 B HIS 515 ? A HIS 130 
109 1 Y 1 B SER 516 ? A SER 131 
110 1 Y 1 B GLY 517 ? A GLY 132 
111 1 Y 1 B LYS 518 ? A LYS 133 
112 1 Y 1 B LEU 519 ? A LEU 134 
113 1 Y 1 B GLU 520 ? A GLU 135 
114 1 Y 1 B HIS 521 ? A HIS 136 
115 1 Y 1 B HIS 522 ? A HIS 137 
116 1 Y 1 B HIS 523 ? A HIS 138 
117 1 Y 1 B HIS 524 ? A HIS 139 
118 1 Y 1 B HIS 525 ? A HIS 140 
119 1 Y 1 B HIS 526 ? A HIS 141 
120 1 Y 1 A MET 386 ? B MET 1   
121 1 Y 1 A GLY 387 ? B GLY 2   
122 1 Y 1 A SER 388 ? B SER 3   
123 1 Y 1 A SER 389 ? B SER 4   
124 1 Y 1 A ASP 390 ? B ASP 5   
125 1 Y 1 A SER 391 ? B SER 6   
126 1 Y 1 A MET 392 ? B MET 7   
127 1 Y 1 A ALA 393 ? B ALA 8   
128 1 Y 1 A GLN 394 ? B GLN 9   
129 1 Y 1 A PRO 395 ? B PRO 10  
130 1 Y 1 A PRO 396 ? B PRO 11  
131 1 Y 1 A GLN 397 ? B GLN 12  
132 1 Y 1 A THR 398 ? B THR 13  
133 1 Y 1 A PRO 399 ? B PRO 14  
134 1 Y 1 A GLU 400 ? B GLU 15  
135 1 Y 1 A THR 401 ? B THR 16  
136 1 Y 1 A SER 402 ? B SER 17  
137 1 Y 1 A THR 403 ? B THR 18  
138 1 Y 1 A PHE 404 ? B PHE 19  
139 1 Y 1 A ARG 405 ? B ARG 20  
140 1 Y 1 A ASN 406 ? B ASN 21  
141 1 Y 1 A GLN 407 ? B GLN 22  
142 1 Y 1 A MET 408 ? B MET 23  
143 1 Y 1 A PRO 409 ? B PRO 24  
144 1 Y 1 A SER 410 ? B SER 25  
145 1 Y 1 A PRO 411 ? B PRO 26  
146 1 Y 1 A THR 412 ? B THR 27  
147 1 Y 1 A SER 413 ? B SER 28  
148 1 Y 1 A THR 414 ? B THR 29  
149 1 Y 1 A GLY 415 ? B GLY 30  
150 1 Y 1 A THR 416 ? B THR 31  
151 1 Y 1 A PRO 417 ? B PRO 32  
152 1 Y 1 A SER 418 ? B SER 33  
153 1 Y 1 A PRO 419 ? B PRO 34  
154 1 Y 1 A GLY 420 ? B GLY 35  
155 1 Y 1 A PRO 421 ? B PRO 36  
156 1 Y 1 A ARG 422 ? B ARG 37  
157 1 Y 1 A GLY 423 ? B GLY 38  
158 1 Y 1 A ASN 424 ? B ASN 39  
159 1 Y 1 A GLN 425 ? B GLN 40  
160 1 Y 1 A GLY 426 ? B GLY 41  
161 1 Y 1 A ALA 427 ? B ALA 42  
162 1 Y 1 A GLU 428 ? B GLU 43  
163 1 Y 1 A ARG 429 ? B ARG 44  
164 1 Y 1 A GLN 430 ? B GLN 45  
165 1 Y 1 A GLY 431 ? B GLY 46  
166 1 Y 1 A MET 432 ? B MET 47  
167 1 Y 1 A ASN 433 ? B ASN 48  
168 1 Y 1 A TRP 434 ? B TRP 49  
169 1 Y 1 A SER 435 ? B SER 50  
170 1 Y 1 A CYS 436 ? B CYS 51  
171 1 Y 1 A ARG 437 ? B ARG 52  
172 1 Y 1 A THR 438 ? B THR 53  
173 1 Y 1 A PRO 439 ? B PRO 54  
174 1 Y 1 A GLU 440 ? B GLU 55  
175 1 Y 1 A PRO 441 ? B PRO 56  
176 1 Y 1 A ASN 442 ? B ASN 57  
177 1 Y 1 A PRO 443 ? B PRO 58  
178 1 Y 1 A VAL 444 ? B VAL 59  
179 1 Y 1 A THR 445 ? B THR 60  
180 1 Y 1 A GLY 446 ? B GLY 61  
181 1 Y 1 A ARG 447 ? B ARG 62  
182 1 Y 1 A GLN 470 ? B GLN 85  
183 1 Y 1 A THR 471 ? B THR 86  
184 1 Y 1 A THR 472 ? B THR 87  
185 1 Y 1 A ALA 473 ? B ALA 88  
186 1 Y 1 A LEU 474 ? B LEU 89  
187 1 Y 1 A PRO 475 ? B PRO 90  
188 1 Y 1 A THR 476 ? B THR 91  
189 1 Y 1 A TRP 477 ? B TRP 92  
190 1 Y 1 A GLY 478 ? B GLY 93  
191 1 Y 1 A LEU 479 ? B LEU 94  
192 1 Y 1 A ALA 480 ? B ALA 95  
193 1 Y 1 A PRO 481 ? B PRO 96  
194 1 Y 1 A SER 482 ? B SER 97  
195 1 Y 1 A GLY 483 ? B GLY 98  
196 1 Y 1 A LYS 484 ? B LYS 99  
197 1 Y 1 A GLY 485 ? B GLY 100 
198 1 Y 1 A ARG 486 ? B ARG 101 
199 1 Y 1 A GLY 487 ? B GLY 102 
200 1 Y 1 A LEU 488 ? B LEU 103 
201 1 Y 1 A GLN 489 ? B GLN 104 
202 1 Y 1 A HIS 490 ? B HIS 105 
203 1 Y 1 A PRO 491 ? B PRO 106 
204 1 Y 1 A PRO 492 ? B PRO 107 
205 1 Y 1 A PRO 493 ? B PRO 108 
206 1 Y 1 A VAL 494 ? B VAL 109 
207 1 Y 1 A GLY 495 ? B GLY 110 
208 1 Y 1 A SER 496 ? B SER 111 
209 1 Y 1 A GLN 497 ? B GLN 112 
210 1 Y 1 A GLU 498 ? B GLU 113 
211 1 Y 1 A GLY 499 ? B GLY 114 
212 1 Y 1 A PRO 500 ? B PRO 115 
213 1 Y 1 A LYS 501 ? B LYS 116 
214 1 Y 1 A ASP 502 ? B ASP 117 
215 1 Y 1 A PRO 503 ? B PRO 118 
216 1 Y 1 A GLU 504 ? B GLU 119 
217 1 Y 1 A ALA 505 ? B ALA 120 
218 1 Y 1 A TRP 506 ? B TRP 121 
219 1 Y 1 A SER 507 ? B SER 122 
220 1 Y 1 A ARG 508 ? B ARG 123 
221 1 Y 1 A PRO 509 ? B PRO 124 
222 1 Y 1 A GLN 510 ? B GLN 125 
223 1 Y 1 A GLY 511 ? B GLY 126 
224 1 Y 1 A TRP 512 ? B TRP 127 
225 1 Y 1 A TYR 513 ? B TYR 128 
226 1 Y 1 A ASN 514 ? B ASN 129 
227 1 Y 1 A HIS 515 ? B HIS 130 
228 1 Y 1 A SER 516 ? B SER 131 
229 1 Y 1 A GLY 517 ? B GLY 132 
230 1 Y 1 A LYS 518 ? B LYS 133 
231 1 Y 1 A LEU 519 ? B LEU 134 
232 1 Y 1 A GLU 520 ? B GLU 135 
233 1 Y 1 A HIS 521 ? B HIS 136 
234 1 Y 1 A HIS 522 ? B HIS 137 
235 1 Y 1 A HIS 523 ? B HIS 138 
236 1 Y 1 A HIS 524 ? B HIS 139 
237 1 Y 1 A HIS 525 ? B HIS 140 
238 1 Y 1 A HIS 526 ? B HIS 141 
239 1 Y 1 C MET 386 ? C MET 1   
240 1 Y 1 C GLY 387 ? C GLY 2   
241 1 Y 1 C SER 388 ? C SER 3   
242 1 Y 1 C SER 389 ? C SER 4   
243 1 Y 1 C ASP 390 ? C ASP 5   
244 1 Y 1 C SER 391 ? C SER 6   
245 1 Y 1 C MET 392 ? C MET 7   
246 1 Y 1 C ALA 393 ? C ALA 8   
247 1 Y 1 C GLN 394 ? C GLN 9   
248 1 Y 1 C PRO 395 ? C PRO 10  
249 1 Y 1 C PRO 396 ? C PRO 11  
250 1 Y 1 C GLN 397 ? C GLN 12  
251 1 Y 1 C THR 398 ? C THR 13  
252 1 Y 1 C PRO 399 ? C PRO 14  
253 1 Y 1 C GLU 400 ? C GLU 15  
254 1 Y 1 C THR 401 ? C THR 16  
255 1 Y 1 C SER 402 ? C SER 17  
256 1 Y 1 C THR 403 ? C THR 18  
257 1 Y 1 C PHE 404 ? C PHE 19  
258 1 Y 1 C ARG 405 ? C ARG 20  
259 1 Y 1 C ASN 406 ? C ASN 21  
260 1 Y 1 C GLN 407 ? C GLN 22  
261 1 Y 1 C MET 408 ? C MET 23  
262 1 Y 1 C PRO 409 ? C PRO 24  
263 1 Y 1 C SER 410 ? C SER 25  
264 1 Y 1 C PRO 411 ? C PRO 26  
265 1 Y 1 C THR 412 ? C THR 27  
266 1 Y 1 C SER 413 ? C SER 28  
267 1 Y 1 C THR 414 ? C THR 29  
268 1 Y 1 C GLY 415 ? C GLY 30  
269 1 Y 1 C THR 416 ? C THR 31  
270 1 Y 1 C PRO 417 ? C PRO 32  
271 1 Y 1 C SER 418 ? C SER 33  
272 1 Y 1 C PRO 419 ? C PRO 34  
273 1 Y 1 C GLY 420 ? C GLY 35  
274 1 Y 1 C PRO 421 ? C PRO 36  
275 1 Y 1 C ARG 422 ? C ARG 37  
276 1 Y 1 C GLY 423 ? C GLY 38  
277 1 Y 1 C ASN 424 ? C ASN 39  
278 1 Y 1 C GLN 425 ? C GLN 40  
279 1 Y 1 C GLY 426 ? C GLY 41  
280 1 Y 1 C ALA 427 ? C ALA 42  
281 1 Y 1 C GLU 428 ? C GLU 43  
282 1 Y 1 C ARG 429 ? C ARG 44  
283 1 Y 1 C GLN 430 ? C GLN 45  
284 1 Y 1 C GLY 431 ? C GLY 46  
285 1 Y 1 C MET 432 ? C MET 47  
286 1 Y 1 C ASN 433 ? C ASN 48  
287 1 Y 1 C TRP 434 ? C TRP 49  
288 1 Y 1 C SER 435 ? C SER 50  
289 1 Y 1 C CYS 436 ? C CYS 51  
290 1 Y 1 C ARG 437 ? C ARG 52  
291 1 Y 1 C THR 438 ? C THR 53  
292 1 Y 1 C PRO 439 ? C PRO 54  
293 1 Y 1 C GLU 440 ? C GLU 55  
294 1 Y 1 C PRO 441 ? C PRO 56  
295 1 Y 1 C ASN 442 ? C ASN 57  
296 1 Y 1 C PRO 443 ? C PRO 58  
297 1 Y 1 C VAL 444 ? C VAL 59  
298 1 Y 1 C THR 445 ? C THR 60  
299 1 Y 1 C GLY 446 ? C GLY 61  
300 1 Y 1 C ARG 447 ? C ARG 62  
301 1 Y 1 C GLN 470 ? C GLN 85  
302 1 Y 1 C THR 471 ? C THR 86  
303 1 Y 1 C THR 472 ? C THR 87  
304 1 Y 1 C ALA 473 ? C ALA 88  
305 1 Y 1 C LEU 474 ? C LEU 89  
306 1 Y 1 C PRO 475 ? C PRO 90  
307 1 Y 1 C THR 476 ? C THR 91  
308 1 Y 1 C TRP 477 ? C TRP 92  
309 1 Y 1 C GLY 478 ? C GLY 93  
310 1 Y 1 C LEU 479 ? C LEU 94  
311 1 Y 1 C ALA 480 ? C ALA 95  
312 1 Y 1 C PRO 481 ? C PRO 96  
313 1 Y 1 C SER 482 ? C SER 97  
314 1 Y 1 C GLY 483 ? C GLY 98  
315 1 Y 1 C LYS 484 ? C LYS 99  
316 1 Y 1 C GLY 485 ? C GLY 100 
317 1 Y 1 C ARG 486 ? C ARG 101 
318 1 Y 1 C GLY 487 ? C GLY 102 
319 1 Y 1 C LEU 488 ? C LEU 103 
320 1 Y 1 C GLN 489 ? C GLN 104 
321 1 Y 1 C HIS 490 ? C HIS 105 
322 1 Y 1 C PRO 491 ? C PRO 106 
323 1 Y 1 C PRO 492 ? C PRO 107 
324 1 Y 1 C PRO 493 ? C PRO 108 
325 1 Y 1 C VAL 494 ? C VAL 109 
326 1 Y 1 C GLY 495 ? C GLY 110 
327 1 Y 1 C SER 496 ? C SER 111 
328 1 Y 1 C GLN 497 ? C GLN 112 
329 1 Y 1 C GLU 498 ? C GLU 113 
330 1 Y 1 C GLY 499 ? C GLY 114 
331 1 Y 1 C PRO 500 ? C PRO 115 
332 1 Y 1 C LYS 501 ? C LYS 116 
333 1 Y 1 C ASP 502 ? C ASP 117 
334 1 Y 1 C PRO 503 ? C PRO 118 
335 1 Y 1 C GLU 504 ? C GLU 119 
336 1 Y 1 C ALA 505 ? C ALA 120 
337 1 Y 1 C TRP 506 ? C TRP 121 
338 1 Y 1 C SER 507 ? C SER 122 
339 1 Y 1 C ARG 508 ? C ARG 123 
340 1 Y 1 C PRO 509 ? C PRO 124 
341 1 Y 1 C GLN 510 ? C GLN 125 
342 1 Y 1 C GLY 511 ? C GLY 126 
343 1 Y 1 C TRP 512 ? C TRP 127 
344 1 Y 1 C TYR 513 ? C TYR 128 
345 1 Y 1 C ASN 514 ? C ASN 129 
346 1 Y 1 C HIS 515 ? C HIS 130 
347 1 Y 1 C SER 516 ? C SER 131 
348 1 Y 1 C GLY 517 ? C GLY 132 
349 1 Y 1 C LYS 518 ? C LYS 133 
350 1 Y 1 C LEU 519 ? C LEU 134 
351 1 Y 1 C GLU 520 ? C GLU 135 
352 1 Y 1 C HIS 521 ? C HIS 136 
353 1 Y 1 C HIS 522 ? C HIS 137 
354 1 Y 1 C HIS 523 ? C HIS 138 
355 1 Y 1 C HIS 524 ? C HIS 139 
356 1 Y 1 C HIS 525 ? C HIS 140 
357 1 Y 1 C HIS 526 ? C HIS 141 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-22 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8Z94 
_em_admin.last_update        2025-04-30 
_em_admin.map_release_date   2025-04-30 
_em_admin.title              'Cryo-EM structure of RIPK1 RHIM PFFs cross seeded RIPK3 RHIM amyloid fibril' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          562 
_em_entity_assembly_recombinant.organism             'Escherichia coli' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_helical_entity.id                             1 
_em_helical_entity.image_processing_id            1 
_em_helical_entity.details                        ? 
_em_helical_entity.axial_symmetry                 C1 
_em_helical_entity.angular_rotation_per_subunit   -7.53 
_em_helical_entity.axial_rise_per_subunit         4.8 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         55 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           82188101 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8Z94 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1   N N   . PRO A 1 63 ? 142.816 164.245 153.957 1.00 101.92 ? 448 PRO B N   1 
ATOM 2   C CA  . PRO A 1 63 ? 142.068 163.761 155.119 1.00 101.92 ? 448 PRO B CA  1 
ATOM 3   C C   . PRO A 1 63 ? 141.985 162.243 155.183 1.00 101.92 ? 448 PRO B C   1 
ATOM 4   O O   . PRO A 1 63 ? 143.013 161.570 155.119 1.00 101.92 ? 448 PRO B O   1 
ATOM 5   C CB  . PRO A 1 63 ? 140.678 164.369 154.917 1.00 101.92 ? 448 PRO B CB  1 
ATOM 6   C CG  . PRO A 1 63 ? 140.574 164.591 153.461 1.00 101.92 ? 448 PRO B CG  1 
ATOM 7   C CD  . PRO A 1 63 ? 141.951 164.983 153.023 1.00 101.92 ? 448 PRO B CD  1 
ATOM 8   N N   . LEU A 1 64 ? 140.761 161.729 155.310 1.00 92.13  ? 449 LEU B N   1 
ATOM 9   C CA  . LEU A 1 64 ? 140.538 160.298 155.479 1.00 92.13  ? 449 LEU B CA  1 
ATOM 10  C C   . LEU A 1 64 ? 141.247 159.510 154.391 1.00 92.13  ? 449 LEU B C   1 
ATOM 11  O O   . LEU A 1 64 ? 141.426 159.984 153.268 1.00 92.13  ? 449 LEU B O   1 
ATOM 12  C CB  . LEU A 1 64 ? 139.044 159.981 155.447 1.00 92.13  ? 449 LEU B CB  1 
ATOM 13  C CG  . LEU A 1 64 ? 138.357 160.032 154.082 1.00 92.13  ? 449 LEU B CG  1 
ATOM 14  C CD1 . LEU A 1 64 ? 137.043 159.283 154.131 1.00 92.13  ? 449 LEU B CD1 1 
ATOM 15  C CD2 . LEU A 1 64 ? 138.126 161.465 153.642 1.00 92.13  ? 449 LEU B CD2 1 
ATOM 16  N N   . VAL A 1 65 ? 141.672 158.297 154.733 1.00 85.65  ? 450 VAL B N   1 
ATOM 17  C CA  . VAL A 1 65 ? 142.398 157.492 153.763 1.00 85.65  ? 450 VAL B CA  1 
ATOM 18  C C   . VAL A 1 65 ? 141.718 156.138 153.586 1.00 85.65  ? 450 VAL B C   1 
ATOM 19  O O   . VAL A 1 65 ? 141.457 155.713 152.457 1.00 85.65  ? 450 VAL B O   1 
ATOM 20  C CB  . VAL A 1 65 ? 143.883 157.369 154.159 1.00 85.65  ? 450 VAL B CB  1 
ATOM 21  C CG1 . VAL A 1 65 ? 144.450 158.744 154.475 1.00 85.65  ? 450 VAL B CG1 1 
ATOM 22  C CG2 . VAL A 1 65 ? 144.095 156.458 155.336 1.00 85.65  ? 450 VAL B CG2 1 
ATOM 23  N N   . ASN A 1 66 ? 141.363 155.484 154.690 1.00 83.63  ? 451 ASN B N   1 
ATOM 24  C CA  . ASN A 1 66 ? 140.687 154.188 154.679 1.00 83.63  ? 451 ASN B CA  1 
ATOM 25  C C   . ASN A 1 66 ? 141.533 153.115 153.975 1.00 83.63  ? 451 ASN B C   1 
ATOM 26  O O   . ASN A 1 66 ? 141.097 152.461 153.043 1.00 83.63  ? 451 ASN B O   1 
ATOM 27  C CB  . ASN A 1 66 ? 139.303 154.317 154.034 1.00 83.63  ? 451 ASN B CB  1 
ATOM 28  C CG  . ASN A 1 66 ? 138.458 155.388 154.692 1.00 83.63  ? 451 ASN B CG  1 
ATOM 29  O OD1 . ASN A 1 66 ? 138.772 156.576 154.615 1.00 83.63  ? 451 ASN B OD1 1 
ATOM 30  N ND2 . ASN A 1 66 ? 137.376 154.975 155.337 1.00 83.63  ? 451 ASN B ND2 1 
ATOM 31  N N   . ILE A 1 67 ? 142.719 152.882 154.527 1.00 73.93  ? 452 ILE B N   1 
ATOM 32  C CA  . ILE A 1 67 ? 143.743 152.093 153.844 1.00 73.93  ? 452 ILE B CA  1 
ATOM 33  C C   . ILE A 1 67 ? 143.430 150.602 153.817 1.00 73.93  ? 452 ILE B C   1 
ATOM 34  O O   . ILE A 1 67 ? 143.345 150.004 152.745 1.00 73.93  ? 452 ILE B O   1 
ATOM 35  C CB  . ILE A 1 67 ? 145.114 152.333 154.493 1.00 73.93  ? 452 ILE B CB  1 
ATOM 36  C CG1 . ILE A 1 67 ? 145.641 153.703 154.102 1.00 73.93  ? 452 ILE B CG1 1 
ATOM 37  C CG2 . ILE A 1 67 ? 146.091 151.295 154.056 1.00 73.93  ? 452 ILE B CG2 1 
ATOM 38  C CD1 . ILE A 1 67 ? 146.903 154.091 154.817 1.00 73.93  ? 452 ILE B CD1 1 
ATOM 39  N N   . TYR A 1 68 ? 143.270 150.000 154.988 1.00 76.88  ? 453 TYR B N   1 
ATOM 40  C CA  . TYR A 1 68 ? 143.113 148.550 155.195 1.00 76.88  ? 453 TYR B CA  1 
ATOM 41  C C   . TYR A 1 68 ? 144.079 147.703 154.375 1.00 76.88  ? 453 TYR B C   1 
ATOM 42  O O   . TYR A 1 68 ? 143.734 146.641 153.861 1.00 76.88  ? 453 TYR B O   1 
ATOM 43  C CB  . TYR A 1 68 ? 141.655 148.094 155.035 1.00 76.88  ? 453 TYR B CB  1 
ATOM 44  C CG  . TYR A 1 68 ? 140.942 148.085 153.698 1.00 76.88  ? 453 TYR B CG  1 
ATOM 45  C CD1 . TYR A 1 68 ? 140.605 149.259 153.044 1.00 76.88  ? 453 TYR B CD1 1 
ATOM 46  C CD2 . TYR A 1 68 ? 140.480 146.890 153.160 1.00 76.88  ? 453 TYR B CD2 1 
ATOM 47  C CE1 . TYR A 1 68 ? 139.909 149.237 151.846 1.00 76.88  ? 453 TYR B CE1 1 
ATOM 48  C CE2 . TYR A 1 68 ? 139.778 146.860 151.962 1.00 76.88  ? 453 TYR B CE2 1 
ATOM 49  C CZ  . TYR A 1 68 ? 139.498 148.039 151.310 1.00 76.88  ? 453 TYR B CZ  1 
ATOM 50  O OH  . TYR A 1 68 ? 138.806 148.024 150.121 1.00 76.88  ? 453 TYR B OH  1 
ATOM 51  N N   . ASN A 1 69 ? 145.342 148.117 154.381 1.00 55.04  ? 454 ASN B N   1 
ATOM 52  C CA  . ASN A 1 69 ? 146.381 147.417 153.640 1.00 55.04  ? 454 ASN B CA  1 
ATOM 53  C C   . ASN A 1 69 ? 146.842 146.184 154.398 1.00 55.04  ? 454 ASN B C   1 
ATOM 54  O O   . ASN A 1 69 ? 146.176 145.687 155.308 1.00 55.04  ? 454 ASN B O   1 
ATOM 55  C CB  . ASN A 1 69 ? 147.541 148.352 153.303 1.00 55.04  ? 454 ASN B CB  1 
ATOM 56  C CG  . ASN A 1 69 ? 148.588 148.486 154.411 1.00 55.04  ? 454 ASN B CG  1 
ATOM 57  O OD1 . ASN A 1 69 ? 148.584 147.797 155.421 1.00 55.04  ? 454 ASN B OD1 1 
ATOM 58  N ND2 . ASN A 1 69 ? 149.528 149.373 154.178 1.00 55.04  ? 454 ASN B ND2 1 
ATOM 59  N N   . CYS A 1 70 ? 147.990 145.655 153.985 1.00 45.89  ? 455 CYS B N   1 
ATOM 60  C CA  . CYS A 1 70 ? 148.633 144.590 154.731 1.00 45.89  ? 455 CYS B CA  1 
ATOM 61  C C   . CYS A 1 70 ? 150.151 144.753 154.791 1.00 45.89  ? 455 CYS B C   1 
ATOM 62  O O   . CYS A 1 70 ? 150.864 143.756 154.938 1.00 45.89  ? 455 CYS B O   1 
ATOM 63  C CB  . CYS A 1 70 ? 148.270 143.227 154.142 1.00 45.89  ? 455 CYS B CB  1 
ATOM 64  S SG  . CYS A 1 70 ? 146.504 142.838 154.217 1.00 45.89  ? 455 CYS B SG  1 
ATOM 65  N N   . SER A 1 71 ? 150.674 145.977 154.679 1.00 35.02  ? 456 SER B N   1 
ATOM 66  C CA  . SER A 1 71 ? 152.094 146.187 154.961 1.00 35.02  ? 456 SER B CA  1 
ATOM 67  C C   . SER A 1 71 ? 152.428 147.671 154.989 1.00 35.02  ? 456 SER B C   1 
ATOM 68  O O   . SER A 1 71 ? 151.548 148.537 154.938 1.00 35.02  ? 456 SER B O   1 
ATOM 69  C CB  . SER A 1 71 ? 153.002 145.492 153.959 1.00 35.02  ? 456 SER B CB  1 
ATOM 70  O OG  . SER A 1 71 ? 154.289 146.061 154.042 1.00 35.02  ? 456 SER B OG  1 
ATOM 71  N N   . GLY A 1 72 ? 153.733 147.945 155.058 1.00 31.90  ? 457 GLY B N   1 
ATOM 72  C CA  . GLY A 1 72 ? 154.316 149.256 155.252 1.00 31.90  ? 457 GLY B CA  1 
ATOM 73  C C   . GLY A 1 72 ? 153.608 150.366 154.524 1.00 31.90  ? 457 GLY B C   1 
ATOM 74  O O   . GLY A 1 72 ? 153.200 150.196 153.379 1.00 31.90  ? 457 GLY B O   1 
ATOM 75  N N   . VAL A 1 73 ? 153.403 151.487 155.195 1.00 27.34  ? 458 VAL B N   1 
ATOM 76  C CA  . VAL A 1 73 ? 152.656 152.586 154.610 1.00 27.34  ? 458 VAL B CA  1 
ATOM 77  C C   . VAL A 1 73 ? 152.881 153.873 155.372 1.00 27.34  ? 458 VAL B C   1 
ATOM 78  O O   . VAL A 1 73 ? 152.844 153.890 156.600 1.00 27.34  ? 458 VAL B O   1 
ATOM 79  C CB  . VAL A 1 73 ? 151.169 152.240 154.560 1.00 27.34  ? 458 VAL B CB  1 
ATOM 80  C CG1 . VAL A 1 73 ? 150.439 153.372 154.092 1.00 27.34  ? 458 VAL B CG1 1 
ATOM 81  C CG2 . VAL A 1 73 ? 150.957 151.148 153.572 1.00 27.34  ? 458 VAL B CG2 1 
ATOM 82  N N   . GLN A 1 74 ? 153.195 154.960 154.671 1.00 25.21  ? 459 GLN B N   1 
ATOM 83  C CA  . GLN A 1 74 ? 153.409 156.237 155.340 1.00 25.21  ? 459 GLN B CA  1 
ATOM 84  C C   . GLN A 1 74 ? 152.562 157.345 154.722 1.00 25.21  ? 459 GLN B C   1 
ATOM 85  O O   . GLN A 1 74 ? 152.431 157.419 153.499 1.00 25.21  ? 459 GLN B O   1 
ATOM 86  C CB  . GLN A 1 74 ? 154.889 156.624 155.292 1.00 25.21  ? 459 GLN B CB  1 
ATOM 87  C CG  . GLN A 1 74 ? 155.732 156.003 156.395 1.00 25.21  ? 459 GLN B CG  1 
ATOM 88  C CD  . GLN A 1 74 ? 157.190 156.411 156.314 1.00 25.21  ? 459 GLN B CD  1 
ATOM 89  O OE1 . GLN A 1 74 ? 157.512 157.599 156.271 1.00 25.21  ? 459 GLN B OE1 1 
ATOM 90  N NE2 . GLN A 1 74 ? 158.080 155.426 156.293 1.00 25.21  ? 459 GLN B NE2 1 
ATOM 91  N N   . VAL A 1 75 ? 151.971 158.187 155.570 1.00 28.17  ? 460 VAL B N   1 
ATOM 92  C CA  . VAL A 1 75 ? 151.170 159.312 155.099 1.00 28.17  ? 460 VAL B CA  1 
ATOM 93  C C   . VAL A 1 75 ? 152.124 160.134 154.253 1.00 28.17  ? 460 VAL B C   1 
ATOM 94  O O   . VAL A 1 75 ? 151.857 160.431 153.089 1.00 28.17  ? 460 VAL B O   1 
ATOM 95  C CB  . VAL A 1 75 ? 150.639 160.164 156.263 1.00 28.17  ? 460 VAL B CB  1 
ATOM 96  C CG1 . VAL A 1 75 ? 149.946 161.410 155.734 1.00 28.17  ? 460 VAL B CG1 1 
ATOM 97  C CG2 . VAL A 1 75 ? 149.694 159.347 157.130 1.00 28.17  ? 460 VAL B CG2 1 
ATOM 98  N N   . GLY A 1 76 ? 153.246 160.494 154.864 1.00 43.93  ? 461 GLY B N   1 
ATOM 99  C CA  . GLY A 1 76 ? 154.304 161.196 154.174 1.00 43.93  ? 461 GLY B CA  1 
ATOM 100 C C   . GLY A 1 76 ? 154.948 162.278 154.996 1.00 43.93  ? 461 GLY B C   1 
ATOM 101 O O   . GLY A 1 76 ? 154.327 163.301 155.292 1.00 43.93  ? 461 GLY B O   1 
ATOM 102 N N   . ASP A 1 77 ? 156.200 162.056 155.357 1.00 74.72  ? 462 ASP B N   1 
ATOM 103 C CA  . ASP A 1 77 ? 156.957 162.943 156.235 1.00 74.72  ? 462 ASP B CA  1 
ATOM 104 C C   . ASP A 1 77 ? 158.392 162.433 156.254 1.00 74.72  ? 462 ASP B C   1 
ATOM 105 O O   . ASP A 1 77 ? 158.775 161.577 155.454 1.00 74.72  ? 462 ASP B O   1 
ATOM 106 C CB  . ASP A 1 77 ? 156.348 163.011 157.635 1.00 74.72  ? 462 ASP B CB  1 
ATOM 107 C CG  . ASP A 1 77 ? 156.721 164.276 158.374 1.00 74.72  ? 462 ASP B CG  1 
ATOM 108 O OD1 . ASP A 1 77 ? 157.346 165.163 157.759 1.00 74.72  ? 462 ASP B OD1 1 
ATOM 109 O OD2 . ASP A 1 77 ? 156.397 164.382 159.572 1.00 74.72  ? 462 ASP B OD2 1 
ATOM 110 N N   . ASN A 1 78 ? 159.176 162.968 157.188 1.00 94.11  ? 463 ASN B N   1 
ATOM 111 C CA  . ASN A 1 78 ? 160.565 162.583 157.384 1.00 94.11  ? 463 ASN B CA  1 
ATOM 112 C C   . ASN A 1 78 ? 160.746 161.103 157.697 1.00 94.11  ? 463 ASN B C   1 
ATOM 113 O O   . ASN A 1 78 ? 159.824 160.430 158.167 1.00 94.11  ? 463 ASN B O   1 
ATOM 114 C CB  . ASN A 1 78 ? 161.168 163.408 158.510 1.00 94.11  ? 463 ASN B CB  1 
ATOM 115 C CG  . ASN A 1 78 ? 160.317 163.381 159.741 1.00 94.11  ? 463 ASN B CG  1 
ATOM 116 O OD1 . ASN A 1 78 ? 159.095 163.335 159.652 1.00 94.11  ? 463 ASN B OD1 1 
ATOM 117 N ND2 . ASN A 1 78 ? 160.951 163.402 160.904 1.00 94.11  ? 463 ASN B ND2 1 
ATOM 118 N N   . ASN A 1 79 ? 161.960 160.617 157.451 1.00 111.17 ? 464 ASN B N   1 
ATOM 119 C CA  . ASN A 1 79 ? 162.408 159.254 157.704 1.00 111.17 ? 464 ASN B CA  1 
ATOM 120 C C   . ASN A 1 79 ? 161.511 158.237 157.019 1.00 111.17 ? 464 ASN B C   1 
ATOM 121 O O   . ASN A 1 79 ? 160.716 157.545 157.661 1.00 111.17 ? 464 ASN B O   1 
ATOM 122 C CB  . ASN A 1 79 ? 162.539 158.993 159.198 1.00 111.17 ? 464 ASN B CB  1 
ATOM 123 C CG  . ASN A 1 79 ? 163.897 159.422 159.723 1.00 111.17 ? 464 ASN B CG  1 
ATOM 124 O OD1 . ASN A 1 79 ? 164.521 160.330 159.171 1.00 111.17 ? 464 ASN B OD1 1 
ATOM 125 N ND2 . ASN A 1 79 ? 164.386 158.746 160.748 1.00 111.17 ? 464 ASN B ND2 1 
ATOM 126 N N   . TYR A 1 80 ? 161.597 158.228 155.691 1.00 97.51  ? 465 TYR B N   1 
ATOM 127 C CA  . TYR A 1 80 ? 160.923 157.301 154.794 1.00 97.51  ? 465 TYR B CA  1 
ATOM 128 C C   . TYR A 1 80 ? 161.119 155.828 155.135 1.00 97.51  ? 465 TYR B C   1 
ATOM 129 O O   . TYR A 1 80 ? 162.253 155.372 155.303 1.00 97.51  ? 465 TYR B O   1 
ATOM 130 C CB  . TYR A 1 80 ? 161.396 157.575 153.380 1.00 97.51  ? 465 TYR B CB  1 
ATOM 131 C CG  . TYR A 1 80 ? 162.852 157.300 153.104 1.00 97.51  ? 465 TYR B CG  1 
ATOM 132 C CD1 . TYR A 1 80 ? 163.837 158.204 153.481 1.00 97.51  ? 465 TYR B CD1 1 
ATOM 133 C CD2 . TYR A 1 80 ? 163.241 156.157 152.423 1.00 97.51  ? 465 TYR B CD2 1 
ATOM 134 C CE1 . TYR A 1 80 ? 165.176 157.961 153.212 1.00 97.51  ? 465 TYR B CE1 1 
ATOM 135 C CE2 . TYR A 1 80 ? 164.572 155.910 152.148 1.00 97.51  ? 465 TYR B CE2 1 
ATOM 136 C CZ  . TYR A 1 80 ? 165.535 156.813 152.545 1.00 97.51  ? 465 TYR B CZ  1 
ATOM 137 O OH  . TYR A 1 80 ? 166.860 156.562 152.270 1.00 97.51  ? 465 TYR B OH  1 
ATOM 138 N N   . LEU A 1 81 ? 160.025 155.067 155.176 1.00 56.73  ? 466 LEU B N   1 
ATOM 139 C CA  . LEU A 1 81 ? 160.021 153.754 155.807 1.00 56.73  ? 466 LEU B CA  1 
ATOM 140 C C   . LEU A 1 81 ? 160.817 152.745 154.988 1.00 56.73  ? 466 LEU B C   1 
ATOM 141 O O   . LEU A 1 81 ? 161.259 153.015 153.872 1.00 56.73  ? 466 LEU B O   1 
ATOM 142 C CB  . LEU A 1 81 ? 158.590 153.261 156.020 1.00 56.73  ? 466 LEU B CB  1 
ATOM 143 C CG  . LEU A 1 81 ? 157.679 152.793 154.887 1.00 56.73  ? 466 LEU B CG  1 
ATOM 144 C CD1 . LEU A 1 81 ? 157.829 151.300 154.695 1.00 56.73  ? 466 LEU B CD1 1 
ATOM 145 C CD2 . LEU A 1 81 ? 156.233 153.128 155.165 1.00 56.73  ? 466 LEU B CD2 1 
ATOM 146 N N   . THR A 1 82 ? 161.016 151.570 155.582 1.00 68.11  ? 467 THR B N   1 
ATOM 147 C CA  . THR A 1 82 ? 161.556 150.406 154.896 1.00 68.11  ? 467 THR B CA  1 
ATOM 148 C C   . THR A 1 82 ? 160.753 149.178 155.289 1.00 68.11  ? 467 THR B C   1 
ATOM 149 O O   . THR A 1 82 ? 159.759 149.262 156.009 1.00 68.11  ? 467 THR B O   1 
ATOM 150 C CB  . THR A 1 82 ? 163.031 150.167 155.218 1.00 68.11  ? 467 THR B CB  1 
ATOM 151 O OG1 . THR A 1 82 ? 163.539 149.148 154.351 1.00 68.11  ? 467 THR B OG1 1 
ATOM 152 C CG2 . THR A 1 82 ? 163.185 149.695 156.638 1.00 68.11  ? 467 THR B CG2 1 
ATOM 153 N N   . MET A 1 83 ? 161.193 148.030 154.802 1.00 71.34  ? 468 MET B N   1 
ATOM 154 C CA  . MET A 1 83 ? 160.589 146.744 155.131 1.00 71.34  ? 468 MET B CA  1 
ATOM 155 C C   . MET A 1 83 ? 161.530 145.670 154.600 1.00 71.34  ? 468 MET B C   1 
ATOM 156 O O   . MET A 1 83 ? 162.641 145.971 154.147 1.00 71.34  ? 468 MET B O   1 
ATOM 157 C CB  . MET A 1 83 ? 159.173 146.638 154.558 1.00 71.34  ? 468 MET B CB  1 
ATOM 158 C CG  . MET A 1 83 ? 158.352 145.477 155.089 1.00 71.34  ? 468 MET B CG  1 
ATOM 159 S SD  . MET A 1 83 ? 156.680 145.421 154.438 1.00 71.34  ? 468 MET B SD  1 
ATOM 160 C CE  . MET A 1 83 ? 156.175 143.788 154.970 1.00 71.34  ? 468 MET B CE  1 
ATOM 161 N N   . GLN A 1 84 ? 161.103 144.415 154.674 1.00 99.21  ? 469 GLN B N   1 
ATOM 162 C CA  . GLN A 1 84 ? 161.817 143.319 154.042 1.00 99.21  ? 469 GLN B CA  1 
ATOM 163 C C   . GLN A 1 84 ? 160.891 142.126 153.832 1.00 99.21  ? 469 GLN B C   1 
ATOM 164 O O   . GLN A 1 84 ? 160.437 141.504 154.792 1.00 99.21  ? 469 GLN B O   1 
ATOM 165 C CB  . GLN A 1 84 ? 163.023 142.903 154.873 1.00 99.21  ? 469 GLN B CB  1 
ATOM 166 C CG  . GLN A 1 84 ? 163.638 141.596 154.418 1.00 99.21  ? 469 GLN B CG  1 
ATOM 167 C CD  . GLN A 1 84 ? 164.035 141.619 152.953 1.00 99.21  ? 469 GLN B CD  1 
ATOM 168 O OE1 . GLN A 1 84 ? 163.232 141.305 152.072 1.00 99.21  ? 469 GLN B OE1 1 
ATOM 169 N NE2 . GLN A 1 84 ? 165.281 141.992 152.686 1.00 99.21  ? 469 GLN B NE2 1 
ATOM 170 N N   . PRO B 1 63 ? 140.681 162.262 149.162 1.00 100.69 ? 448 PRO A N   1 
ATOM 171 C CA  . PRO B 1 63 ? 140.083 161.695 150.373 1.00 100.69 ? 448 PRO A CA  1 
ATOM 172 C C   . PRO B 1 63 ? 140.329 160.200 150.514 1.00 100.69 ? 448 PRO A C   1 
ATOM 173 O O   . PRO B 1 63 ? 141.477 159.760 150.447 1.00 100.69 ? 448 PRO A O   1 
ATOM 174 C CB  . PRO B 1 63 ? 138.590 161.981 150.191 1.00 100.69 ? 448 PRO A CB  1 
ATOM 175 C CG  . PRO B 1 63 ? 138.405 162.093 148.730 1.00 100.69 ? 448 PRO A CG  1 
ATOM 176 C CD  . PRO B 1 63 ? 139.655 162.745 148.225 1.00 100.69 ? 448 PRO A CD  1 
ATOM 177 N N   . LEU B 1 64 ? 139.249 159.445 150.710 1.00 99.45  ? 449 LEU A N   1 
ATOM 178 C CA  . LEU B 1 64 ? 139.343 158.011 150.957 1.00 99.45  ? 449 LEU A CA  1 
ATOM 179 C C   . LEU B 1 64 ? 140.179 157.333 149.885 1.00 99.45  ? 449 LEU A C   1 
ATOM 180 O O   . LEU B 1 64 ? 140.224 157.771 148.733 1.00 99.45  ? 449 LEU A O   1 
ATOM 181 C CB  . LEU B 1 64 ? 137.951 157.381 150.994 1.00 99.45  ? 449 LEU A CB  1 
ATOM 182 C CG  . LEU B 1 64 ? 137.237 157.208 149.654 1.00 99.45  ? 449 LEU A CG  1 
ATOM 183 C CD1 . LEU B 1 64 ? 136.117 156.199 149.787 1.00 99.45  ? 449 LEU A CD1 1 
ATOM 184 C CD2 . LEU B 1 64 ? 136.692 158.532 149.152 1.00 99.45  ? 449 LEU A CD2 1 
ATOM 185 N N   . VAL B 1 65 ? 140.862 156.260 150.270 1.00 87.38  ? 450 VAL A N   1 
ATOM 186 C CA  . VAL B 1 65 ? 141.721 155.576 149.316 1.00 87.38  ? 450 VAL A CA  1 
ATOM 187 C C   . VAL B 1 65 ? 141.344 154.100 149.230 1.00 87.38  ? 450 VAL A C   1 
ATOM 188 O O   . VAL B 1 65 ? 141.153 153.567 148.133 1.00 87.38  ? 450 VAL A O   1 
ATOM 189 C CB  . VAL B 1 65 ? 143.207 155.795 149.664 1.00 87.38  ? 450 VAL A CB  1 
ATOM 190 C CG1 . VAL B 1 65 ? 143.472 157.274 149.892 1.00 87.38  ? 450 VAL A CG1 1 
ATOM 191 C CG2 . VAL B 1 65 ? 143.638 155.017 150.876 1.00 87.38  ? 450 VAL A CG2 1 
ATOM 192 N N   . ASN B 1 66 ? 141.165 153.448 150.377 1.00 86.07  ? 451 ASN A N   1 
ATOM 193 C CA  . ASN B 1 66 ? 140.783 152.039 150.454 1.00 86.07  ? 451 ASN A CA  1 
ATOM 194 C C   . ASN B 1 66 ? 141.823 151.134 149.774 1.00 86.07  ? 451 ASN A C   1 
ATOM 195 O O   . ASN B 1 66 ? 141.514 150.351 148.891 1.00 86.07  ? 451 ASN A O   1 
ATOM 196 C CB  . ASN B 1 66 ? 139.388 151.833 149.854 1.00 86.07  ? 451 ASN A CB  1 
ATOM 197 C CG  . ASN B 1 66 ? 138.349 152.734 150.488 1.00 86.07  ? 451 ASN A CG  1 
ATOM 198 O OD1 . ASN B 1 66 ? 138.399 153.955 150.342 1.00 86.07  ? 451 ASN A OD1 1 
ATOM 199 N ND2 . ASN B 1 66 ? 137.397 152.136 151.191 1.00 86.07  ? 451 ASN A ND2 1 
ATOM 200 N N   . ILE B 1 67 ? 143.045 151.191 150.294 1.00 71.94  ? 452 ILE A N   1 
ATOM 201 C CA  . ILE B 1 67 ? 144.197 150.602 149.614 1.00 71.94  ? 452 ILE A CA  1 
ATOM 202 C C   . ILE B 1 67 ? 144.212 149.079 149.671 1.00 71.94  ? 452 ILE A C   1 
ATOM 203 O O   . ILE B 1 67 ? 144.231 148.418 148.634 1.00 71.94  ? 452 ILE A O   1 
ATOM 204 C CB  . ILE B 1 67 ? 145.499 151.165 150.201 1.00 71.94  ? 452 ILE A CB  1 
ATOM 205 C CG1 . ILE B 1 67 ? 145.710 152.591 149.724 1.00 71.94  ? 452 ILE A CG1 1 
ATOM 206 C CG2 . ILE B 1 67 ? 146.666 150.336 149.781 1.00 71.94  ? 452 ILE A CG2 1 
ATOM 207 C CD1 . ILE B 1 67 ? 146.876 153.279 150.374 1.00 71.94  ? 452 ILE A CD1 1 
ATOM 208 N N   . TYR B 1 68 ? 144.213 148.523 150.877 1.00 78.32  ? 453 TYR A N   1 
ATOM 209 C CA  . TYR B 1 68 ? 144.377 147.087 151.160 1.00 78.32  ? 453 TYR A CA  1 
ATOM 210 C C   . TYR B 1 68 ? 145.482 146.421 150.348 1.00 78.32  ? 453 TYR A C   1 
ATOM 211 O O   . TYR B 1 68 ? 145.361 145.283 149.900 1.00 78.32  ? 453 TYR A O   1 
ATOM 212 C CB  . TYR B 1 68 ? 143.048 146.322 151.074 1.00 78.32  ? 453 TYR A CB  1 
ATOM 213 C CG  . TYR B 1 68 ? 142.322 146.086 149.766 1.00 78.32  ? 453 TYR A CG  1 
ATOM 214 C CD1 . TYR B 1 68 ? 141.723 147.123 149.068 1.00 78.32  ? 453 TYR A CD1 1 
ATOM 215 C CD2 . TYR B 1 68 ? 142.114 144.791 149.305 1.00 78.32  ? 453 TYR A CD2 1 
ATOM 216 C CE1 . TYR B 1 68 ? 141.020 146.886 147.898 1.00 78.32  ? 453 TYR A CE1 1 
ATOM 217 C CE2 . TYR B 1 68 ? 141.406 144.546 148.135 1.00 78.32  ? 453 TYR A CE2 1 
ATOM 218 C CZ  . TYR B 1 68 ? 140.863 145.599 147.437 1.00 78.32  ? 453 TYR A CZ  1 
ATOM 219 O OH  . TYR B 1 68 ? 140.162 145.371 146.275 1.00 78.32  ? 453 TYR A OH  1 
ATOM 220 N N   . ASN B 1 69 ? 146.627 147.095 150.289 1.00 51.22  ? 454 ASN A N   1 
ATOM 221 C CA  . ASN B 1 69 ? 147.773 146.593 149.546 1.00 51.22  ? 454 ASN A CA  1 
ATOM 222 C C   . ASN B 1 69 ? 148.507 145.531 150.347 1.00 51.22  ? 454 ASN A C   1 
ATOM 223 O O   . ASN B 1 69 ? 147.986 144.954 151.303 1.00 51.22  ? 454 ASN A O   1 
ATOM 224 C CB  . ASN B 1 69 ? 148.697 147.733 149.122 1.00 51.22  ? 454 ASN A CB  1 
ATOM 225 C CG  . ASN B 1 69 ? 149.716 148.150 150.184 1.00 51.22  ? 454 ASN A CG  1 
ATOM 226 O OD1 . ASN B 1 69 ? 149.886 147.533 151.226 1.00 51.22  ? 454 ASN A OD1 1 
ATOM 227 N ND2 . ASN B 1 69 ? 150.438 149.202 149.874 1.00 51.22  ? 454 ASN A ND2 1 
ATOM 228 N N   . CYS B 1 70 ? 149.732 145.237 149.920 1.00 44.95  ? 455 CYS A N   1 
ATOM 229 C CA  . CYS B 1 70 ? 150.606 144.377 150.694 1.00 44.95  ? 455 CYS A CA  1 
ATOM 230 C C   . CYS B 1 70 ? 152.055 144.864 150.691 1.00 44.95  ? 455 CYS A C   1 
ATOM 231 O O   . CYS B 1 70 ? 152.970 144.052 150.862 1.00 44.95  ? 455 CYS A O   1 
ATOM 232 C CB  . CYS B 1 70 ? 150.531 142.937 150.186 1.00 44.95  ? 455 CYS A CB  1 
ATOM 233 S SG  . CYS B 1 70 ? 148.892 142.185 150.343 1.00 44.95  ? 455 CYS A SG  1 
ATOM 234 N N   . SER B 1 71 ? 152.300 146.162 150.500 1.00 36.06  ? 456 SER A N   1 
ATOM 235 C CA  . SER B 1 71 ? 153.647 146.687 150.721 1.00 36.06  ? 456 SER A CA  1 
ATOM 236 C C   . SER B 1 71 ? 153.655 148.207 150.664 1.00 36.06  ? 456 SER A C   1 
ATOM 237 O O   . SER B 1 71 ? 152.608 148.861 150.602 1.00 36.06  ? 456 SER A O   1 
ATOM 238 C CB  . SER B 1 71 ? 154.659 146.147 149.722 1.00 36.06  ? 456 SER A CB  1 
ATOM 239 O OG  . SER B 1 71 ? 155.795 146.981 149.731 1.00 36.06  ? 456 SER A OG  1 
ATOM 240 N N   . GLY B 1 72 ? 154.872 148.756 150.672 1.00 36.98  ? 457 GLY A N   1 
ATOM 241 C CA  . GLY B 1 72 ? 155.164 150.171 150.780 1.00 36.98  ? 457 GLY A CA  1 
ATOM 242 C C   . GLY B 1 72 ? 154.216 151.061 150.025 1.00 36.98  ? 457 GLY A C   1 
ATOM 243 O O   . GLY B 1 72 ? 153.827 150.745 148.905 1.00 36.98  ? 457 GLY A O   1 
ATOM 244 N N   . VAL B 1 73 ? 153.812 152.158 150.662 1.00 27.69  ? 458 VAL A N   1 
ATOM 245 C CA  . VAL B 1 73 ? 152.887 153.121 150.072 1.00 27.69  ? 458 VAL A CA  1 
ATOM 246 C C   . VAL B 1 73 ? 152.889 154.417 150.873 1.00 27.69  ? 458 VAL A C   1 
ATOM 247 O O   . VAL B 1 73 ? 153.276 154.432 152.042 1.00 27.69  ? 458 VAL A O   1 
ATOM 248 C CB  . VAL B 1 73 ? 151.444 152.581 150.039 1.00 27.69  ? 458 VAL A CB  1 
ATOM 249 C CG1 . VAL B 1 73 ? 150.489 153.653 149.534 1.00 27.69  ? 458 VAL A CG1 1 
ATOM 250 C CG2 . VAL B 1 73 ? 151.364 151.335 149.171 1.00 27.69  ? 458 VAL A CG2 1 
ATOM 251 N N   . GLN B 1 74 ? 152.447 155.500 150.241 1.00 23.88  ? 459 GLN A N   1 
ATOM 252 C CA  . GLN B 1 74 ? 152.392 156.805 150.892 1.00 23.88  ? 459 GLN A CA  1 
ATOM 253 C C   . GLN B 1 74 ? 151.454 157.753 150.153 1.00 23.88  ? 459 GLN A C   1 
ATOM 254 O O   . GLN B 1 74 ? 151.420 157.770 148.923 1.00 23.88  ? 459 GLN A O   1 
ATOM 255 C CB  . GLN B 1 74 ? 153.790 157.424 150.975 1.00 23.88  ? 459 GLN A CB  1 
ATOM 256 C CG  . GLN B 1 74 ? 154.743 156.680 151.897 1.00 23.88  ? 459 GLN A CG  1 
ATOM 257 C CD  . GLN B 1 74 ? 156.136 157.277 151.898 1.00 23.88  ? 459 GLN A CD  1 
ATOM 258 O OE1 . GLN B 1 74 ? 156.549 157.922 150.934 1.00 23.88  ? 459 GLN A OE1 1 
ATOM 259 N NE2 . GLN B 1 74 ? 156.870 157.065 152.984 1.00 23.88  ? 459 GLN A NE2 1 
ATOM 260 N N   . VAL B 1 75 ? 150.690 158.537 150.909 1.00 31.30  ? 460 VAL A N   1 
ATOM 261 C CA  . VAL B 1 75 ? 149.765 159.496 150.319 1.00 31.30  ? 460 VAL A CA  1 
ATOM 262 C C   . VAL B 1 75 ? 150.541 160.427 149.397 1.00 31.30  ? 460 VAL A C   1 
ATOM 263 O O   . VAL B 1 75 ? 150.110 160.724 148.283 1.00 31.30  ? 460 VAL A O   1 
ATOM 264 C CB  . VAL B 1 75 ? 149.048 160.329 151.397 1.00 31.30  ? 460 VAL A CB  1 
ATOM 265 C CG1 . VAL B 1 75 ? 148.368 161.536 150.770 1.00 31.30  ? 460 VAL A CG1 1 
ATOM 266 C CG2 . VAL B 1 75 ? 148.042 159.470 152.148 1.00 31.30  ? 460 VAL A CG2 1 
ATOM 267 N N   . GLY B 1 76 ? 151.693 160.882 149.878 1.00 33.59  ? 461 GLY A N   1 
ATOM 268 C CA  . GLY B 1 76 ? 152.558 161.753 149.117 1.00 33.59  ? 461 GLY A CA  1 
ATOM 269 C C   . GLY B 1 76 ? 152.973 162.993 149.862 1.00 33.59  ? 461 GLY A C   1 
ATOM 270 O O   . GLY B 1 76 ? 152.154 163.874 150.128 1.00 33.59  ? 461 GLY A O   1 
ATOM 271 N N   . ASP B 1 77 ? 154.252 163.063 150.188 1.00 67.97  ? 462 ASP A N   1 
ATOM 272 C CA  . ASP B 1 77 ? 154.822 164.139 150.993 1.00 67.97  ? 462 ASP A CA  1 
ATOM 273 C C   . ASP B 1 77 ? 156.333 163.949 150.986 1.00 67.97  ? 462 ASP A C   1 
ATOM 274 O O   . ASP B 1 77 ? 156.872 163.151 150.216 1.00 67.97  ? 462 ASP A O   1 
ATOM 275 C CB  . ASP B 1 77 ? 154.247 164.153 152.409 1.00 67.97  ? 462 ASP A CB  1 
ATOM 276 C CG  . ASP B 1 77 ? 154.357 165.508 153.071 1.00 67.97  ? 462 ASP A CG  1 
ATOM 277 O OD1 . ASP B 1 77 ? 154.762 166.472 152.391 1.00 67.97  ? 462 ASP A OD1 1 
ATOM 278 O OD2 . ASP B 1 77 ? 154.047 165.609 154.273 1.00 67.97  ? 462 ASP A OD2 1 
ATOM 279 N N   . ASN B 1 78 ? 157.007 164.690 151.864 1.00 86.11  ? 463 ASN A N   1 
ATOM 280 C CA  . ASN B 1 78 ? 158.450 164.622 152.028 1.00 86.11  ? 463 ASN A CA  1 
ATOM 281 C C   . ASN B 1 78 ? 158.952 163.235 152.407 1.00 86.11  ? 463 ASN A C   1 
ATOM 282 O O   . ASN B 1 78 ? 158.209 162.408 152.943 1.00 86.11  ? 463 ASN A O   1 
ATOM 283 C CB  . ASN B 1 78 ? 158.888 165.619 153.090 1.00 86.11  ? 463 ASN A CB  1 
ATOM 284 C CG  . ASN B 1 78 ? 158.094 165.479 154.351 1.00 86.11  ? 463 ASN A CG  1 
ATOM 285 O OD1 . ASN B 1 78 ? 156.909 165.168 154.308 1.00 86.11  ? 463 ASN A OD1 1 
ATOM 286 N ND2 . ASN B 1 78 ? 158.736 165.699 155.488 1.00 86.11  ? 463 ASN A ND2 1 
ATOM 287 N N   . ASN B 1 79 ? 160.237 163.007 152.142 1.00 108.43 ? 464 ASN A N   1 
ATOM 288 C CA  . ASN B 1 79 ? 160.973 161.787 152.446 1.00 108.43 ? 464 ASN A CA  1 
ATOM 289 C C   . ASN B 1 79 ? 160.300 160.565 151.844 1.00 108.43 ? 464 ASN A C   1 
ATOM 290 O O   . ASN B 1 79 ? 159.688 159.756 152.548 1.00 108.43 ? 464 ASN A O   1 
ATOM 291 C CB  . ASN B 1 79 ? 161.193 161.643 153.945 1.00 108.43 ? 464 ASN A CB  1 
ATOM 292 C CG  . ASN B 1 79 ? 162.440 162.381 154.400 1.00 108.43 ? 464 ASN A CG  1 
ATOM 293 O OD1 . ASN B 1 79 ? 162.841 163.369 153.782 1.00 108.43 ? 464 ASN A OD1 1 
ATOM 294 N ND2 . ASN B 1 79 ? 163.087 161.883 155.438 1.00 108.43 ? 464 ASN A ND2 1 
ATOM 295 N N   . TYR B 1 80 ? 160.353 160.500 150.516 1.00 109.24 ? 465 TYR A N   1 
ATOM 296 C CA  . TYR B 1 80 ? 159.872 159.403 149.691 1.00 109.24 ? 465 TYR A CA  1 
ATOM 297 C C   . TYR B 1 80 ? 160.389 158.027 150.096 1.00 109.24 ? 465 TYR A C   1 
ATOM 298 O O   . TYR B 1 80 ? 161.598 157.834 150.246 1.00 109.24 ? 465 TYR A O   1 
ATOM 299 C CB  . TYR B 1 80 ? 160.241 159.692 148.249 1.00 109.24 ? 465 TYR A CB  1 
ATOM 300 C CG  . TYR B 1 80 ? 161.715 159.719 147.934 1.00 109.24 ? 465 TYR A CG  1 
ATOM 301 C CD1 . TYR B 1 80 ? 162.491 160.832 148.231 1.00 109.24 ? 465 TYR A CD1 1 
ATOM 302 C CD2 . TYR B 1 80 ? 162.324 158.650 147.298 1.00 109.24 ? 465 TYR A CD2 1 
ATOM 303 C CE1 . TYR B 1 80 ? 163.844 160.866 147.927 1.00 109.24 ? 465 TYR A CE1 1 
ATOM 304 C CE2 . TYR B 1 80 ? 163.670 158.678 146.987 1.00 109.24 ? 465 TYR A CE2 1 
ATOM 305 C CZ  . TYR B 1 80 ? 164.425 159.785 147.304 1.00 109.24 ? 465 TYR A CZ  1 
ATOM 306 O OH  . TYR B 1 80 ? 165.765 159.808 146.995 1.00 109.24 ? 465 TYR A OH  1 
ATOM 307 N N   . LEU B 1 81 ? 159.485 157.053 150.214 1.00 69.15  ? 466 LEU A N   1 
ATOM 308 C CA  . LEU B 1 81 ? 159.780 155.807 150.908 1.00 69.15  ? 466 LEU A CA  1 
ATOM 309 C C   . LEU B 1 81 ? 160.754 154.947 150.113 1.00 69.15  ? 466 LEU A C   1 
ATOM 310 O O   . LEU B 1 81 ? 161.100 155.242 148.969 1.00 69.15  ? 466 LEU A O   1 
ATOM 311 C CB  . LEU B 1 81 ? 158.494 155.032 151.197 1.00 69.15  ? 466 LEU A CB  1 
ATOM 312 C CG  . LEU B 1 81 ? 157.678 154.318 150.121 1.00 69.15  ? 466 LEU A CG  1 
ATOM 313 C CD1 . LEU B 1 81 ? 158.140 152.883 149.998 1.00 69.15  ? 466 LEU A CD1 1 
ATOM 314 C CD2 . LEU B 1 81 ? 156.200 154.352 150.435 1.00 69.15  ? 466 LEU A CD2 1 
ATOM 315 N N   . THR B 1 82 ? 161.216 153.876 150.756 1.00 80.44  ? 467 THR A N   1 
ATOM 316 C CA  . THR B 1 82 ? 161.976 152.818 150.109 1.00 80.44  ? 467 THR A CA  1 
ATOM 317 C C   . THR B 1 82 ? 161.466 151.471 150.590 1.00 80.44  ? 467 THR A C   1 
ATOM 318 O O   . THR B 1 82 ? 160.495 151.381 151.340 1.00 80.44  ? 467 THR A O   1 
ATOM 319 C CB  . THR B 1 82 ? 163.476 152.918 150.390 1.00 80.44  ? 467 THR A CB  1 
ATOM 320 O OG1 . THR B 1 82 ? 164.170 151.985 149.556 1.00 80.44  ? 467 THR A OG1 1 
ATOM 321 C CG2 . THR B 1 82 ? 163.762 152.570 151.825 1.00 80.44  ? 467 THR A CG2 1 
ATOM 322 N N   . MET B 1 83 ? 162.131 150.418 150.145 1.00 81.21  ? 468 MET A N   1 
ATOM 323 C CA  . MET B 1 83 ? 161.825 149.053 150.559 1.00 81.21  ? 468 MET A CA  1 
ATOM 324 C C   . MET B 1 83 ? 162.962 148.177 150.048 1.00 81.21  ? 468 MET A C   1 
ATOM 325 O O   . MET B 1 83 ? 163.971 148.683 149.540 1.00 81.21  ? 468 MET A O   1 
ATOM 326 C CB  . MET B 1 83 ? 160.452 148.615 150.043 1.00 81.21  ? 468 MET A CB  1 
ATOM 327 C CG  . MET B 1 83 ? 159.913 147.338 150.659 1.00 81.21  ? 468 MET A CG  1 
ATOM 328 S SD  . MET B 1 83 ? 158.277 146.889 150.072 1.00 81.21  ? 468 MET A SD  1 
ATOM 329 C CE  . MET B 1 83 ? 158.149 145.218 150.701 1.00 81.21  ? 468 MET A CE  1 
ATOM 330 N N   . GLN B 1 84 ? 162.818 146.866 150.199 1.00 108.62 ? 469 GLN A N   1 
ATOM 331 C CA  . GLN B 1 84 ? 163.734 145.914 149.596 1.00 108.62 ? 469 GLN A CA  1 
ATOM 332 C C   . GLN B 1 84 ? 163.082 144.541 149.479 1.00 108.62 ? 469 GLN A C   1 
ATOM 333 O O   . GLN B 1 84 ? 162.796 143.891 150.483 1.00 108.62 ? 469 GLN A O   1 
ATOM 334 C CB  . GLN B 1 84 ? 165.022 145.812 150.403 1.00 108.62 ? 469 GLN A CB  1 
ATOM 335 C CG  . GLN B 1 84 ? 165.893 144.643 149.992 1.00 108.62 ? 469 GLN A CG  1 
ATOM 336 C CD  . GLN B 1 84 ? 166.239 144.668 148.514 1.00 108.62 ? 469 GLN A CD  1 
ATOM 337 O OE1 . GLN B 1 84 ? 165.501 144.142 147.678 1.00 108.62 ? 469 GLN A OE1 1 
ATOM 338 N NE2 . GLN B 1 84 ? 167.368 145.284 148.184 1.00 108.62 ? 469 GLN A NE2 1 
ATOM 339 N N   . PRO C 1 63 ? 144.557 164.567 158.989 1.00 102.72 ? 448 PRO C N   1 
ATOM 340 C CA  . PRO C 1 63 ? 143.724 164.154 160.120 1.00 102.72 ? 448 PRO C CA  1 
ATOM 341 C C   . PRO C 1 63 ? 143.380 162.672 160.094 1.00 102.72 ? 448 PRO C C   1 
ATOM 342 O O   . PRO C 1 63 ? 144.278 161.837 159.993 1.00 102.72 ? 448 PRO C O   1 
ATOM 343 C CB  . PRO C 1 63 ? 142.462 165.003 159.952 1.00 102.72 ? 448 PRO C CB  1 
ATOM 344 C CG  . PRO C 1 63 ? 142.413 165.322 158.511 1.00 102.72 ? 448 PRO C CG  1 
ATOM 345 C CD  . PRO C 1 63 ? 143.843 165.496 158.099 1.00 102.72 ? 448 PRO C CD  1 
ATOM 346 N N   . LEU C 1 64 ? 142.085 162.369 160.190 1.00 96.30  ? 449 LEU C N   1 
ATOM 347 C CA  . LEU C 1 64 ? 141.617 160.992 160.274 1.00 96.30  ? 449 LEU C CA  1 
ATOM 348 C C   . LEU C 1 64 ? 142.192 160.157 159.144 1.00 96.30  ? 449 LEU C C   1 
ATOM 349 O O   . LEU C 1 64 ? 142.463 160.657 158.049 1.00 96.30  ? 449 LEU C O   1 
ATOM 350 C CB  . LEU C 1 64 ? 140.091 160.939 160.222 1.00 96.30  ? 449 LEU C CB  1 
ATOM 351 C CG  . LEU C 1 64 ? 139.439 161.186 158.862 1.00 96.30  ? 449 LEU C CG  1 
ATOM 352 C CD1 . LEU C 1 64 ? 138.015 160.673 158.866 1.00 96.30  ? 449 LEU C CD1 1 
ATOM 353 C CD2 . LEU C 1 64 ? 139.462 162.660 158.506 1.00 96.30  ? 449 LEU C CD2 1 
ATOM 354 N N   . VAL C 1 65 ? 142.398 158.871 159.414 1.00 91.73  ? 450 VAL C N   1 
ATOM 355 C CA  . VAL C 1 65 ? 142.986 158.010 158.399 1.00 91.73  ? 450 VAL C CA  1 
ATOM 356 C C   . VAL C 1 65 ? 142.085 156.806 158.142 1.00 91.73  ? 450 VAL C C   1 
ATOM 357 O O   . VAL C 1 65 ? 141.768 156.498 156.990 1.00 91.73  ? 450 VAL C O   1 
ATOM 358 C CB  . VAL C 1 65 ? 144.423 157.610 158.789 1.00 91.73  ? 450 VAL C CB  1 
ATOM 359 C CG1 . VAL C 1 65 ? 145.215 158.846 159.186 1.00 91.73  ? 450 VAL C CG1 1 
ATOM 360 C CG2 . VAL C 1 65 ? 144.462 156.610 159.911 1.00 91.73  ? 450 VAL C CG2 1 
ATOM 361 N N   . ASN C 1 66 ? 141.610 156.161 159.207 1.00 95.19  ? 451 ASN C N   1 
ATOM 362 C CA  . ASN C 1 66 ? 140.722 155.003 159.118 1.00 95.19  ? 451 ASN C CA  1 
ATOM 363 C C   . ASN C 1 66 ? 141.378 153.843 158.354 1.00 95.19  ? 451 ASN C C   1 
ATOM 364 O O   . ASN C 1 66 ? 140.846 153.329 157.385 1.00 95.19  ? 451 ASN C O   1 
ATOM 365 C CB  . ASN C 1 66 ? 139.387 155.406 158.481 1.00 95.19  ? 451 ASN C CB  1 
ATOM 366 C CG  . ASN C 1 66 ? 138.732 156.567 159.200 1.00 95.19  ? 451 ASN C CG  1 
ATOM 367 O OD1 . ASN C 1 66 ? 139.247 157.685 159.193 1.00 95.19  ? 451 ASN C OD1 1 
ATOM 368 N ND2 . ASN C 1 66 ? 137.588 156.310 159.818 1.00 95.19  ? 451 ASN C ND2 1 
ATOM 369 N N   . ILE C 1 67 ? 142.501 153.378 158.893 1.00 84.05  ? 452 ILE C N   1 
ATOM 370 C CA  . ILE C 1 67 ? 143.381 152.464 158.166 1.00 84.05  ? 452 ILE C CA  1 
ATOM 371 C C   . ILE C 1 67 ? 142.816 151.053 158.051 1.00 84.05  ? 452 ILE C C   1 
ATOM 372 O O   . ILE C 1 67 ? 142.642 150.542 156.946 1.00 84.05  ? 452 ILE C O   1 
ATOM 373 C CB  . ILE C 1 67 ? 144.765 152.427 158.829 1.00 84.05  ? 452 ILE C CB  1 
ATOM 374 C CG1 . ILE C 1 67 ? 145.525 153.705 158.519 1.00 84.05  ? 452 ILE C CG1 1 
ATOM 375 C CG2 . ILE C 1 67 ? 145.554 151.263 158.333 1.00 84.05  ? 452 ILE C CG2 1 
ATOM 376 C CD1 . ILE C 1 67 ? 146.826 153.828 159.258 1.00 84.05  ? 452 ILE C CD1 1 
ATOM 377 N N   . TYR C 1 68 ? 142.541 150.422 159.185 1.00 86.69  ? 453 TYR C N   1 
ATOM 378 C CA  . TYR C 1 68 ? 142.136 149.011 159.307 1.00 86.69  ? 453 TYR C CA  1 
ATOM 379 C C   . TYR C 1 68 ? 142.950 148.059 158.439 1.00 86.69  ? 453 TYR C C   1 
ATOM 380 O O   . TYR C 1 68 ? 142.433 147.104 157.864 1.00 86.69  ? 453 TYR C O   1 
ATOM 381 C CB  . TYR C 1 68 ? 140.623 148.824 159.118 1.00 86.69  ? 453 TYR C CB  1 
ATOM 382 C CG  . TYR C 1 68 ? 139.934 149.014 157.783 1.00 86.69  ? 453 TYR C CG  1 
ATOM 383 C CD1 . TYR C 1 68 ? 139.811 150.265 157.199 1.00 86.69  ? 453 TYR C CD1 1 
ATOM 384 C CD2 . TYR C 1 68 ? 139.278 147.950 157.176 1.00 86.69  ? 453 TYR C CD2 1 
ATOM 385 C CE1 . TYR C 1 68 ? 139.135 150.432 156.000 1.00 86.69  ? 453 TYR C CE1 1 
ATOM 386 C CE2 . TYR C 1 68 ? 138.595 148.110 155.977 1.00 86.69  ? 453 TYR C CE2 1 
ATOM 387 C CZ  . TYR C 1 68 ? 138.529 149.355 155.395 1.00 86.69  ? 453 TYR C CZ  1 
ATOM 388 O OH  . TYR C 1 68 ? 137.859 149.528 154.206 1.00 86.69  ? 453 TYR C OH  1 
ATOM 389 N N   . ASN C 1 69 ? 144.266 148.248 158.471 1.00 74.86  ? 454 ASN C N   1 
ATOM 390 C CA  . ASN C 1 69 ? 145.177 147.423 157.691 1.00 74.86  ? 454 ASN C CA  1 
ATOM 391 C C   . ASN C 1 69 ? 145.411 146.088 158.376 1.00 74.86  ? 454 ASN C C   1 
ATOM 392 O O   . ASN C 1 69 ? 144.658 145.661 159.255 1.00 74.86  ? 454 ASN C O   1 
ATOM 393 C CB  . ASN C 1 69 ? 146.485 148.162 157.411 1.00 74.86  ? 454 ASN C CB  1 
ATOM 394 C CG  . ASN C 1 69 ? 147.526 148.050 158.526 1.00 74.86  ? 454 ASN C CG  1 
ATOM 395 O OD1 . ASN C 1 69 ? 147.393 147.314 159.494 1.00 74.86  ? 454 ASN C OD1 1 
ATOM 396 N ND2 . ASN C 1 69 ? 148.607 148.773 158.347 1.00 74.86  ? 454 ASN C ND2 1 
ATOM 397 N N   . CYS C 1 70 ? 146.455 145.393 157.934 1.00 76.86  ? 455 CYS C N   1 
ATOM 398 C CA  . CYS C 1 70 ? 146.896 144.193 158.617 1.00 76.86  ? 455 CYS C CA  1 
ATOM 399 C C   . CYS C 1 70 ? 148.419 144.088 158.689 1.00 76.86  ? 455 CYS C C   1 
ATOM 400 O O   . CYS C 1 70 ? 148.949 142.976 158.778 1.00 76.86  ? 455 CYS C O   1 
ATOM 401 C CB  . CYS C 1 70 ? 146.311 142.948 157.950 1.00 76.86  ? 455 CYS C CB  1 
ATOM 402 S SG  . CYS C 1 70 ? 144.503 142.866 158.000 1.00 76.86  ? 455 CYS C SG  1 
ATOM 403 N N   . SER C 1 71 ? 149.146 145.207 158.649 1.00 65.31  ? 456 SER C N   1 
ATOM 404 C CA  . SER C 1 71 ? 150.578 145.153 158.944 1.00 65.31  ? 456 SER C CA  1 
ATOM 405 C C   . SER C 1 71 ? 151.162 146.553 159.060 1.00 65.31  ? 456 SER C C   1 
ATOM 406 O O   . SER C 1 71 ? 150.444 147.559 159.059 1.00 65.31  ? 456 SER C O   1 
ATOM 407 C CB  . SER C 1 71 ? 151.364 144.371 157.904 1.00 65.31  ? 456 SER C CB  1 
ATOM 408 O OG  . SER C 1 71 ? 152.729 144.704 158.022 1.00 65.31  ? 456 SER C OG  1 
ATOM 409 N N   . GLY C 1 72 ? 152.493 146.593 159.145 1.00 49.78  ? 457 GLY C N   1 
ATOM 410 C CA  . GLY C 1 72 ? 153.292 147.771 159.417 1.00 49.78  ? 457 GLY C CA  1 
ATOM 411 C C   . GLY C 1 72 ? 152.793 149.026 158.754 1.00 49.78  ? 457 GLY C C   1 
ATOM 412 O O   . GLY C 1 72 ? 152.375 148.995 157.601 1.00 49.78  ? 457 GLY C O   1 
ATOM 413 N N   . VAL C 1 73 ? 152.804 150.125 159.505 1.00 42.61  ? 458 VAL C N   1 
ATOM 414 C CA  . VAL C 1 73 ? 152.344 151.420 159.016 1.00 42.61  ? 458 VAL C CA  1 
ATOM 415 C C   . VAL C 1 73 ? 152.802 152.531 159.954 1.00 42.61  ? 458 VAL C C   1 
ATOM 416 O O   . VAL C 1 73 ? 153.117 152.280 161.118 1.00 42.61  ? 458 VAL C O   1 
ATOM 417 C CB  . VAL C 1 73 ? 150.808 151.477 158.916 1.00 42.61  ? 458 VAL C CB  1 
ATOM 418 C CG1 . VAL C 1 73 ? 150.354 152.874 158.523 1.00 42.61  ? 458 VAL C CG1 1 
ATOM 419 C CG2 . VAL C 1 73 ? 150.303 150.446 157.918 1.00 42.61  ? 458 VAL C CG2 1 
ATOM 420 N N   . GLN C 1 74 ? 152.830 153.758 159.443 1.00 43.22  ? 459 GLN C N   1 
ATOM 421 C CA  . GLN C 1 74 ? 153.246 154.912 160.232 1.00 43.22  ? 459 GLN C CA  1 
ATOM 422 C C   . GLN C 1 74 ? 152.768 156.212 159.595 1.00 43.22  ? 459 GLN C C   1 
ATOM 423 O O   . GLN C 1 74 ? 152.802 156.360 158.374 1.00 43.22  ? 459 GLN C O   1 
ATOM 424 C CB  . GLN C 1 74 ? 154.770 154.940 160.379 1.00 43.22  ? 459 GLN C CB  1 
ATOM 425 C CG  . GLN C 1 74 ? 155.337 153.802 161.211 1.00 43.22  ? 459 GLN C CG  1 
ATOM 426 C CD  . GLN C 1 74 ? 156.851 153.823 161.272 1.00 43.22  ? 459 GLN C CD  1 
ATOM 427 O OE1 . GLN C 1 74 ? 157.513 154.358 160.382 1.00 43.22  ? 459 GLN C OE1 1 
ATOM 428 N NE2 . GLN C 1 74 ? 157.408 153.240 162.327 1.00 43.22  ? 459 GLN C NE2 1 
ATOM 429 N N   . VAL C 1 75 ? 152.317 157.147 160.426 1.00 41.05  ? 460 VAL C N   1 
ATOM 430 C CA  . VAL C 1 75 ? 151.849 158.438 159.937 1.00 41.05  ? 460 VAL C CA  1 
ATOM 431 C C   . VAL C 1 75 ? 152.968 159.090 159.136 1.00 41.05  ? 460 VAL C C   1 
ATOM 432 O O   . VAL C 1 75 ? 152.745 159.630 158.053 1.00 41.05  ? 460 VAL C O   1 
ATOM 433 C CB  . VAL C 1 75 ? 151.440 159.369 161.092 1.00 41.05  ? 460 VAL C CB  1 
ATOM 434 C CG1 . VAL C 1 75 ? 150.934 160.696 160.549 1.00 41.05  ? 460 VAL C CG1 1 
ATOM 435 C CG2 . VAL C 1 75 ? 150.384 158.703 161.961 1.00 41.05  ? 460 VAL C CG2 1 
ATOM 436 N N   . GLY C 1 76 ? 154.176 159.029 159.686 1.00 63.90  ? 461 GLY C N   1 
ATOM 437 C CA  . GLY C 1 76 ? 155.346 159.576 159.039 1.00 63.90  ? 461 GLY C CA  1 
ATOM 438 C C   . GLY C 1 76 ? 156.158 160.482 159.924 1.00 63.90  ? 461 GLY C C   1 
ATOM 439 O O   . GLY C 1 76 ? 155.718 161.578 160.278 1.00 63.90  ? 461 GLY C O   1 
ATOM 440 N N   . ASP C 1 77 ? 157.349 160.027 160.273 1.00 93.95  ? 462 ASP C N   1 
ATOM 441 C CA  . ASP C 1 77 ? 158.237 160.719 161.201 1.00 93.95  ? 462 ASP C CA  1 
ATOM 442 C C   . ASP C 1 77 ? 159.562 159.969 161.192 1.00 93.95  ? 462 ASP C C   1 
ATOM 443 O O   . ASP C 1 77 ? 159.802 159.106 160.344 1.00 93.95  ? 462 ASP C O   1 
ATOM 444 C CB  . ASP C 1 77 ? 157.633 160.810 162.602 1.00 93.95  ? 462 ASP C CB  1 
ATOM 445 C CG  . ASP C 1 77 ? 158.210 161.947 163.414 1.00 93.95  ? 462 ASP C CG  1 
ATOM 446 O OD1 . ASP C 1 77 ? 158.985 162.747 162.853 1.00 93.95  ? 462 ASP C OD1 1 
ATOM 447 O OD2 . ASP C 1 77 ? 157.896 162.038 164.616 1.00 93.95  ? 462 ASP C OD2 1 
ATOM 448 N N   . ASN C 1 78 ? 160.417 160.305 162.157 1.00 105.13 ? 463 ASN C N   1 
ATOM 449 C CA  . ASN C 1 78 ? 161.716 159.676 162.331 1.00 105.13 ? 463 ASN C CA  1 
ATOM 450 C C   . ASN C 1 78 ? 161.636 158.172 162.557 1.00 105.13 ? 463 ASN C C   1 
ATOM 451 O O   . ASN C 1 78 ? 160.607 157.642 162.987 1.00 105.13 ? 463 ASN C O   1 
ATOM 452 C CB  . ASN C 1 78 ? 162.439 160.320 163.504 1.00 105.13 ? 463 ASN C CB  1 
ATOM 453 C CG  . ASN C 1 78 ? 161.583 160.368 164.731 1.00 105.13 ? 463 ASN C CG  1 
ATOM 454 O OD1 . ASN C 1 78 ? 160.372 160.539 164.637 1.00 105.13 ? 463 ASN C OD1 1 
ATOM 455 N ND2 . ASN C 1 78 ? 162.198 160.213 165.894 1.00 105.13 ? 463 ASN C ND2 1 
ATOM 456 N N   . ASN C 1 79 ? 162.752 157.499 162.285 1.00 113.72 ? 464 ASN C N   1 
ATOM 457 C CA  . ASN C 1 79 ? 162.955 156.067 162.458 1.00 113.72 ? 464 ASN C CA  1 
ATOM 458 C C   . ASN C 1 79 ? 161.905 155.260 161.713 1.00 113.72 ? 464 ASN C C   1 
ATOM 459 O O   . ASN C 1 79 ? 160.995 154.680 162.313 1.00 113.72 ? 464 ASN C O   1 
ATOM 460 C CB  . ASN C 1 79 ? 163.022 155.702 163.934 1.00 113.72 ? 464 ASN C CB  1 
ATOM 461 C CG  . ASN C 1 79 ? 164.429 155.859 164.485 1.00 113.72 ? 464 ASN C CG  1 
ATOM 462 O OD1 . ASN C 1 79 ? 165.206 156.676 163.988 1.00 113.72 ? 464 ASN C OD1 1 
ATOM 463 N ND2 . ASN C 1 79 ? 164.782 155.051 165.469 1.00 113.72 ? 464 ASN C ND2 1 
ATOM 464 N N   . TYR C 1 80 ? 162.003 155.313 160.387 1.00 93.26  ? 465 TYR C N   1 
ATOM 465 C CA  . TYR C 1 80 ? 161.189 154.570 159.437 1.00 93.26  ? 465 TYR C CA  1 
ATOM 466 C C   . TYR C 1 80 ? 161.125 153.067 159.691 1.00 93.26  ? 465 TYR C C   1 
ATOM 467 O O   . TYR C 1 80 ? 162.162 152.414 159.834 1.00 93.26  ? 465 TYR C O   1 
ATOM 468 C CB  . TYR C 1 80 ? 161.718 154.838 158.042 1.00 93.26  ? 465 TYR C CB  1 
ATOM 469 C CG  . TYR C 1 80 ? 163.108 154.333 157.751 1.00 93.26  ? 465 TYR C CG  1 
ATOM 470 C CD1 . TYR C 1 80 ? 164.229 155.030 158.182 1.00 93.26  ? 465 TYR C CD1 1 
ATOM 471 C CD2 . TYR C 1 80 ? 163.302 153.181 157.006 1.00 93.26  ? 465 TYR C CD2 1 
ATOM 472 C CE1 . TYR C 1 80 ? 165.509 154.576 157.901 1.00 93.26  ? 465 TYR C CE1 1 
ATOM 473 C CE2 . TYR C 1 80 ? 164.574 152.725 156.718 1.00 93.26  ? 465 TYR C CE2 1 
ATOM 474 C CZ  . TYR C 1 80 ? 165.673 153.423 157.168 1.00 93.26  ? 465 TYR C CZ  1 
ATOM 475 O OH  . TYR C 1 80 ? 166.937 152.964 156.881 1.00 93.26  ? 465 TYR C OH  1 
ATOM 476 N N   . LEU C 1 81 ? 159.915 152.505 159.687 1.00 69.99  ? 466 LEU C N   1 
ATOM 477 C CA  . LEU C 1 81 ? 159.679 151.179 160.239 1.00 69.99  ? 466 LEU C CA  1 
ATOM 478 C C   . LEU C 1 81 ? 160.299 150.096 159.364 1.00 69.99  ? 466 LEU C C   1 
ATOM 479 O O   . LEU C 1 81 ? 160.793 150.349 158.266 1.00 69.99  ? 466 LEU C O   1 
ATOM 480 C CB  . LEU C 1 81 ? 158.182 150.928 160.422 1.00 69.99  ? 466 LEU C CB  1 
ATOM 481 C CG  . LEU C 1 81 ? 157.217 150.690 159.262 1.00 69.99  ? 466 LEU C CG  1 
ATOM 482 C CD1 . LEU C 1 81 ? 157.110 149.207 158.984 1.00 69.99  ? 466 LEU C CD1 1 
ATOM 483 C CD2 . LEU C 1 81 ? 155.847 151.254 159.559 1.00 69.99  ? 466 LEU C CD2 1 
ATOM 484 N N   . THR C 1 82 ? 160.286 148.872 159.888 1.00 76.80  ? 467 THR C N   1 
ATOM 485 C CA  . THR C 1 82 ? 160.625 147.674 159.136 1.00 76.80  ? 467 THR C CA  1 
ATOM 486 C C   . THR C 1 82 ? 159.618 146.582 159.455 1.00 76.80  ? 467 THR C C   1 
ATOM 487 O O   . THR C 1 82 ? 158.646 146.795 160.178 1.00 76.80  ? 467 THR C O   1 
ATOM 488 C CB  . THR C 1 82 ? 162.034 147.166 159.445 1.00 76.80  ? 467 THR C CB  1 
ATOM 489 O OG1 . THR C 1 82 ? 162.368 146.127 158.521 1.00 76.80  ? 467 THR C OG1 1 
ATOM 490 C CG2 . THR C 1 82 ? 162.088 146.594 160.835 1.00 76.80  ? 467 THR C CG2 1 
ATOM 491 N N   . MET C 1 83 ? 159.860 145.406 158.903 1.00 101.95 ? 468 MET C N   1 
ATOM 492 C CA  . MET C 1 83 ? 159.040 144.226 159.156 1.00 101.95 ? 468 MET C CA  1 
ATOM 493 C C   . MET C 1 83 ? 159.788 143.038 158.563 1.00 101.95 ? 468 MET C C   1 
ATOM 494 O O   . MET C 1 83 ? 160.939 143.169 158.130 1.00 101.95 ? 468 MET C O   1 
ATOM 495 C CB  . MET C 1 83 ? 157.633 144.399 158.576 1.00 101.95 ? 468 MET C CB  1 
ATOM 496 C CG  . MET C 1 83 ? 156.619 143.369 159.037 1.00 101.95 ? 468 MET C CG  1 
ATOM 497 S SD  . MET C 1 83 ? 154.969 143.639 158.382 1.00 101.95 ? 468 MET C SD  1 
ATOM 498 C CE  . MET C 1 83 ? 154.185 142.089 158.817 1.00 101.95 ? 468 MET C CE  1 
ATOM 499 N N   . GLN C 1 84 ? 159.151 141.874 158.564 1.00 123.68 ? 469 GLN C N   1 
ATOM 500 C CA  . GLN C 1 84 ? 159.672 140.709 157.869 1.00 123.68 ? 469 GLN C CA  1 
ATOM 501 C C   . GLN C 1 84 ? 158.557 139.708 157.589 1.00 123.68 ? 469 GLN C C   1 
ATOM 502 O O   . GLN C 1 84 ? 157.992 139.120 158.510 1.00 123.68 ? 469 GLN C O   1 
ATOM 503 C CB  . GLN C 1 84 ? 160.780 140.044 158.676 1.00 123.68 ? 469 GLN C CB  1 
ATOM 504 C CG  . GLN C 1 84 ? 161.166 138.679 158.146 1.00 123.68 ? 469 GLN C CG  1 
ATOM 505 C CD  . GLN C 1 84 ? 161.577 138.717 156.686 1.00 123.68 ? 469 GLN C CD  1 
ATOM 506 O OE1 . GLN C 1 84 ? 160.742 138.598 155.787 1.00 123.68 ? 469 GLN C OE1 1 
ATOM 507 N NE2 . GLN C 1 84 ? 162.871 138.885 156.442 1.00 123.68 ? 469 GLN C NE2 1 
# 
