data_8Z80
# 
_entry.id   8Z80 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Z80         pdb_00008z80 10.2210/pdb8z80/pdb 
WWPDB D_1300047181 ?            ?                   
EMDB  EMD-39834    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-08 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Z80 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'SLC19A2-Pyridoxine inward structure' 
_pdbx_database_related.db_id          EMD-39834 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
4 qqh@fudan.edu.cn Qianhui Qu  ? 'principal investigator/group leader' 0000-0002-5753-2599 
5 gaopu@ibp.ac.cn  Pu      Gao ? 'principal investigator/group leader' 0000-0002-5328-9755 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Li, P.P.'  1 ? 
'Zhu, Z.N.' 2 ? 
'Wang, Y.'  3 ? 
'Gao, P.'   4 ? 
'Qu, Q.H.'  5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                10924 
_citation.page_last                 10924 
_citation.title                     'Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-55359-8 
_citation.pdbx_database_id_PubMed   39738067 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Li, P.'    1  ?                   
primary 'Zhu, Z.'   2  ?                   
primary 'Wang, Y.'  3  ?                   
primary 'Zhang, X.' 4  0000-0002-6305-1556 
primary 'Yang, C.'  5  ?                   
primary 'Zhu, Y.'   6  ?                   
primary 'Zhou, Z.'  7  ?                   
primary 'Chao, Y.'  8  ?                   
primary 'Long, Y.'  9  ?                   
primary 'Gao, Y.'   10 ?                   
primary 'Liu, S.'   11 ?                   
primary 'Zhang, L.' 12 0000-0002-9795-0314 
primary 'Gao, P.'   13 0000-0002-5328-9755 
primary 'Qu, Q.'    14 0000-0002-5753-2599 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Thiamine transporter 1'                       55432.605 1 ? ? ? ? 
2 non-polymer syn '4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol' 169.178   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'ThTr-1,ThTr1,Solute carrier family 19 member 2,Thiamine carrier 1,TC1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYS
YLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSY
CRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTD
TPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLW
EKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIY
MLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMK
KCRKLEDPQSSSQVTTS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYS
YLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSY
CRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTD
TPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLW
EKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIY
MLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMK
KCRKLEDPQSSSQVTTS
;
_entity_poly.pdbx_strand_id                 B 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        '4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol' 
_pdbx_entity_nonpoly.comp_id     UEG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   VAL n 
1 4   PRO n 
1 5   GLY n 
1 6   PRO n 
1 7   VAL n 
1 8   SER n 
1 9   ARG n 
1 10  ARG n 
1 11  ALA n 
1 12  ALA n 
1 13  ALA n 
1 14  ALA n 
1 15  ALA n 
1 16  ALA n 
1 17  THR n 
1 18  VAL n 
1 19  LEU n 
1 20  LEU n 
1 21  ARG n 
1 22  THR n 
1 23  ALA n 
1 24  ARG n 
1 25  VAL n 
1 26  ARG n 
1 27  ARG n 
1 28  GLU n 
1 29  CYS n 
1 30  TRP n 
1 31  PHE n 
1 32  LEU n 
1 33  PRO n 
1 34  THR n 
1 35  ALA n 
1 36  LEU n 
1 37  LEU n 
1 38  CYS n 
1 39  ALA n 
1 40  TYR n 
1 41  GLY n 
1 42  PHE n 
1 43  PHE n 
1 44  ALA n 
1 45  SER n 
1 46  LEU n 
1 47  ARG n 
1 48  PRO n 
1 49  SER n 
1 50  GLU n 
1 51  PRO n 
1 52  PHE n 
1 53  LEU n 
1 54  THR n 
1 55  PRO n 
1 56  TYR n 
1 57  LEU n 
1 58  LEU n 
1 59  GLY n 
1 60  PRO n 
1 61  ASP n 
1 62  LYS n 
1 63  ASN n 
1 64  LEU n 
1 65  THR n 
1 66  GLU n 
1 67  ARG n 
1 68  GLU n 
1 69  VAL n 
1 70  PHE n 
1 71  ASN n 
1 72  GLU n 
1 73  ILE n 
1 74  TYR n 
1 75  PRO n 
1 76  VAL n 
1 77  TRP n 
1 78  THR n 
1 79  TYR n 
1 80  SER n 
1 81  TYR n 
1 82  LEU n 
1 83  VAL n 
1 84  LEU n 
1 85  LEU n 
1 86  PHE n 
1 87  PRO n 
1 88  VAL n 
1 89  PHE n 
1 90  LEU n 
1 91  ALA n 
1 92  THR n 
1 93  ASP n 
1 94  TYR n 
1 95  LEU n 
1 96  ARG n 
1 97  TYR n 
1 98  LYS n 
1 99  PRO n 
1 100 VAL n 
1 101 VAL n 
1 102 LEU n 
1 103 LEU n 
1 104 GLN n 
1 105 GLY n 
1 106 LEU n 
1 107 SER n 
1 108 LEU n 
1 109 ILE n 
1 110 VAL n 
1 111 THR n 
1 112 TRP n 
1 113 PHE n 
1 114 MET n 
1 115 LEU n 
1 116 LEU n 
1 117 TYR n 
1 118 ALA n 
1 119 GLN n 
1 120 GLY n 
1 121 LEU n 
1 122 LEU n 
1 123 ALA n 
1 124 ILE n 
1 125 GLN n 
1 126 PHE n 
1 127 LEU n 
1 128 GLU n 
1 129 PHE n 
1 130 PHE n 
1 131 TYR n 
1 132 GLY n 
1 133 ILE n 
1 134 ALA n 
1 135 THR n 
1 136 ALA n 
1 137 THR n 
1 138 GLU n 
1 139 ILE n 
1 140 ALA n 
1 141 TYR n 
1 142 TYR n 
1 143 SER n 
1 144 TYR n 
1 145 ILE n 
1 146 TYR n 
1 147 SER n 
1 148 VAL n 
1 149 VAL n 
1 150 ASP n 
1 151 LEU n 
1 152 GLY n 
1 153 MET n 
1 154 TYR n 
1 155 GLN n 
1 156 LYS n 
1 157 VAL n 
1 158 THR n 
1 159 SER n 
1 160 TYR n 
1 161 CYS n 
1 162 ARG n 
1 163 SER n 
1 164 ALA n 
1 165 THR n 
1 166 LEU n 
1 167 VAL n 
1 168 GLY n 
1 169 PHE n 
1 170 THR n 
1 171 VAL n 
1 172 GLY n 
1 173 SER n 
1 174 VAL n 
1 175 LEU n 
1 176 GLY n 
1 177 GLN n 
1 178 ILE n 
1 179 LEU n 
1 180 VAL n 
1 181 SER n 
1 182 VAL n 
1 183 ALA n 
1 184 GLY n 
1 185 TRP n 
1 186 SER n 
1 187 LEU n 
1 188 PHE n 
1 189 SER n 
1 190 LEU n 
1 191 ASN n 
1 192 VAL n 
1 193 ILE n 
1 194 SER n 
1 195 LEU n 
1 196 THR n 
1 197 CYS n 
1 198 VAL n 
1 199 SER n 
1 200 VAL n 
1 201 ALA n 
1 202 PHE n 
1 203 ALA n 
1 204 VAL n 
1 205 ALA n 
1 206 TRP n 
1 207 PHE n 
1 208 LEU n 
1 209 PRO n 
1 210 MET n 
1 211 PRO n 
1 212 GLN n 
1 213 LYS n 
1 214 SER n 
1 215 LEU n 
1 216 PHE n 
1 217 PHE n 
1 218 HIS n 
1 219 HIS n 
1 220 ILE n 
1 221 PRO n 
1 222 SER n 
1 223 THR n 
1 224 CYS n 
1 225 GLN n 
1 226 ARG n 
1 227 VAL n 
1 228 ASN n 
1 229 GLY n 
1 230 ILE n 
1 231 LYS n 
1 232 VAL n 
1 233 GLN n 
1 234 ASN n 
1 235 GLY n 
1 236 GLY n 
1 237 ILE n 
1 238 VAL n 
1 239 THR n 
1 240 ASP n 
1 241 THR n 
1 242 PRO n 
1 243 ALA n 
1 244 SER n 
1 245 ASN n 
1 246 HIS n 
1 247 LEU n 
1 248 PRO n 
1 249 GLY n 
1 250 TRP n 
1 251 GLU n 
1 252 ASP n 
1 253 ILE n 
1 254 GLU n 
1 255 SER n 
1 256 LYS n 
1 257 ILE n 
1 258 PRO n 
1 259 LEU n 
1 260 ASN n 
1 261 MET n 
1 262 GLU n 
1 263 GLU n 
1 264 PRO n 
1 265 PRO n 
1 266 VAL n 
1 267 GLU n 
1 268 GLU n 
1 269 PRO n 
1 270 GLU n 
1 271 PRO n 
1 272 LYS n 
1 273 PRO n 
1 274 ASP n 
1 275 ARG n 
1 276 LEU n 
1 277 LEU n 
1 278 VAL n 
1 279 LEU n 
1 280 LYS n 
1 281 VAL n 
1 282 LEU n 
1 283 TRP n 
1 284 ASN n 
1 285 ASP n 
1 286 PHE n 
1 287 LEU n 
1 288 MET n 
1 289 CYS n 
1 290 TYR n 
1 291 SER n 
1 292 SER n 
1 293 ARG n 
1 294 PRO n 
1 295 LEU n 
1 296 LEU n 
1 297 CYS n 
1 298 TRP n 
1 299 SER n 
1 300 VAL n 
1 301 TRP n 
1 302 TRP n 
1 303 ALA n 
1 304 LEU n 
1 305 SER n 
1 306 THR n 
1 307 CYS n 
1 308 GLY n 
1 309 TYR n 
1 310 PHE n 
1 311 GLN n 
1 312 VAL n 
1 313 VAL n 
1 314 ASN n 
1 315 TYR n 
1 316 THR n 
1 317 GLN n 
1 318 GLY n 
1 319 LEU n 
1 320 TRP n 
1 321 GLU n 
1 322 LYS n 
1 323 VAL n 
1 324 MET n 
1 325 PRO n 
1 326 SER n 
1 327 ARG n 
1 328 TYR n 
1 329 ALA n 
1 330 ALA n 
1 331 ILE n 
1 332 TYR n 
1 333 ASN n 
1 334 GLY n 
1 335 GLY n 
1 336 VAL n 
1 337 GLU n 
1 338 ALA n 
1 339 VAL n 
1 340 SER n 
1 341 THR n 
1 342 LEU n 
1 343 LEU n 
1 344 GLY n 
1 345 ALA n 
1 346 VAL n 
1 347 ALA n 
1 348 VAL n 
1 349 PHE n 
1 350 ALA n 
1 351 VAL n 
1 352 GLY n 
1 353 TYR n 
1 354 ILE n 
1 355 LYS n 
1 356 ILE n 
1 357 SER n 
1 358 TRP n 
1 359 SER n 
1 360 THR n 
1 361 TRP n 
1 362 GLY n 
1 363 GLU n 
1 364 MET n 
1 365 THR n 
1 366 LEU n 
1 367 SER n 
1 368 LEU n 
1 369 PHE n 
1 370 SER n 
1 371 LEU n 
1 372 LEU n 
1 373 ILE n 
1 374 ALA n 
1 375 ALA n 
1 376 ALA n 
1 377 VAL n 
1 378 TYR n 
1 379 ILE n 
1 380 MET n 
1 381 ASP n 
1 382 THR n 
1 383 VAL n 
1 384 GLY n 
1 385 ASN n 
1 386 ILE n 
1 387 TRP n 
1 388 VAL n 
1 389 CYS n 
1 390 TYR n 
1 391 ALA n 
1 392 SER n 
1 393 TYR n 
1 394 VAL n 
1 395 VAL n 
1 396 PHE n 
1 397 ARG n 
1 398 ILE n 
1 399 ILE n 
1 400 TYR n 
1 401 MET n 
1 402 LEU n 
1 403 LEU n 
1 404 ILE n 
1 405 THR n 
1 406 ILE n 
1 407 ALA n 
1 408 THR n 
1 409 PHE n 
1 410 GLN n 
1 411 ILE n 
1 412 ALA n 
1 413 ALA n 
1 414 ASN n 
1 415 LEU n 
1 416 SER n 
1 417 MET n 
1 418 GLU n 
1 419 ARG n 
1 420 TYR n 
1 421 ALA n 
1 422 LEU n 
1 423 VAL n 
1 424 PHE n 
1 425 GLY n 
1 426 VAL n 
1 427 ASN n 
1 428 THR n 
1 429 PHE n 
1 430 ILE n 
1 431 ALA n 
1 432 LEU n 
1 433 ALA n 
1 434 LEU n 
1 435 GLN n 
1 436 THR n 
1 437 LEU n 
1 438 LEU n 
1 439 THR n 
1 440 LEU n 
1 441 ILE n 
1 442 VAL n 
1 443 VAL n 
1 444 ASP n 
1 445 ALA n 
1 446 SER n 
1 447 GLY n 
1 448 LEU n 
1 449 GLY n 
1 450 LEU n 
1 451 GLU n 
1 452 ILE n 
1 453 THR n 
1 454 THR n 
1 455 GLN n 
1 456 PHE n 
1 457 LEU n 
1 458 ILE n 
1 459 TYR n 
1 460 ALA n 
1 461 SER n 
1 462 TYR n 
1 463 PHE n 
1 464 ALA n 
1 465 LEU n 
1 466 ILE n 
1 467 ALA n 
1 468 VAL n 
1 469 VAL n 
1 470 PHE n 
1 471 LEU n 
1 472 ALA n 
1 473 SER n 
1 474 GLY n 
1 475 ALA n 
1 476 VAL n 
1 477 SER n 
1 478 VAL n 
1 479 MET n 
1 480 LYS n 
1 481 LYS n 
1 482 CYS n 
1 483 ARG n 
1 484 LYS n 
1 485 LEU n 
1 486 GLU n 
1 487 ASP n 
1 488 PRO n 
1 489 GLN n 
1 490 SER n 
1 491 SER n 
1 492 SER n 
1 493 GLN n 
1 494 VAL n 
1 495 THR n 
1 496 THR n 
1 497 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   497 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC19A2, THT1, TRMA' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                        ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                       ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                     ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                       ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                      ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                        ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                      ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE                                     ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                        ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                         ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                     ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                  ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                        ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                         ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                      ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                     ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                       ? 'C9 H11 N O3'    181.189 
UEG non-polymer         . '4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol' ? 'C8 H11 N O3'    169.178 
VAL 'L-peptide linking' y VALINE                                         ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   B . n 
A 1 2   ASP 2   2   ?   ?   ?   B . n 
A 1 3   VAL 3   3   ?   ?   ?   B . n 
A 1 4   PRO 4   4   ?   ?   ?   B . n 
A 1 5   GLY 5   5   ?   ?   ?   B . n 
A 1 6   PRO 6   6   ?   ?   ?   B . n 
A 1 7   VAL 7   7   ?   ?   ?   B . n 
A 1 8   SER 8   8   ?   ?   ?   B . n 
A 1 9   ARG 9   9   ?   ?   ?   B . n 
A 1 10  ARG 10  10  ?   ?   ?   B . n 
A 1 11  ALA 11  11  ?   ?   ?   B . n 
A 1 12  ALA 12  12  ?   ?   ?   B . n 
A 1 13  ALA 13  13  ?   ?   ?   B . n 
A 1 14  ALA 14  14  ?   ?   ?   B . n 
A 1 15  ALA 15  15  ?   ?   ?   B . n 
A 1 16  ALA 16  16  ?   ?   ?   B . n 
A 1 17  THR 17  17  ?   ?   ?   B . n 
A 1 18  VAL 18  18  ?   ?   ?   B . n 
A 1 19  LEU 19  19  ?   ?   ?   B . n 
A 1 20  LEU 20  20  ?   ?   ?   B . n 
A 1 21  ARG 21  21  ?   ?   ?   B . n 
A 1 22  THR 22  22  ?   ?   ?   B . n 
A 1 23  ALA 23  23  ?   ?   ?   B . n 
A 1 24  ARG 24  24  ?   ?   ?   B . n 
A 1 25  VAL 25  25  ?   ?   ?   B . n 
A 1 26  ARG 26  26  ?   ?   ?   B . n 
A 1 27  ARG 27  27  ?   ?   ?   B . n 
A 1 28  GLU 28  28  ?   ?   ?   B . n 
A 1 29  CYS 29  29  ?   ?   ?   B . n 
A 1 30  TRP 30  30  ?   ?   ?   B . n 
A 1 31  PHE 31  31  31  PHE PHE B . n 
A 1 32  LEU 32  32  32  LEU LEU B . n 
A 1 33  PRO 33  33  33  PRO PRO B . n 
A 1 34  THR 34  34  34  THR THR B . n 
A 1 35  ALA 35  35  35  ALA ALA B . n 
A 1 36  LEU 36  36  36  LEU LEU B . n 
A 1 37  LEU 37  37  37  LEU LEU B . n 
A 1 38  CYS 38  38  38  CYS CYS B . n 
A 1 39  ALA 39  39  39  ALA ALA B . n 
A 1 40  TYR 40  40  40  TYR TYR B . n 
A 1 41  GLY 41  41  41  GLY GLY B . n 
A 1 42  PHE 42  42  42  PHE PHE B . n 
A 1 43  PHE 43  43  43  PHE PHE B . n 
A 1 44  ALA 44  44  44  ALA ALA B . n 
A 1 45  SER 45  45  45  SER SER B . n 
A 1 46  LEU 46  46  46  LEU LEU B . n 
A 1 47  ARG 47  47  47  ARG ARG B . n 
A 1 48  PRO 48  48  48  PRO PRO B . n 
A 1 49  SER 49  49  49  SER SER B . n 
A 1 50  GLU 50  50  50  GLU GLU B . n 
A 1 51  PRO 51  51  51  PRO PRO B . n 
A 1 52  PHE 52  52  52  PHE PHE B . n 
A 1 53  LEU 53  53  53  LEU LEU B . n 
A 1 54  THR 54  54  54  THR THR B . n 
A 1 55  PRO 55  55  55  PRO PRO B . n 
A 1 56  TYR 56  56  56  TYR TYR B . n 
A 1 57  LEU 57  57  57  LEU LEU B . n 
A 1 58  LEU 58  58  58  LEU LEU B . n 
A 1 59  GLY 59  59  59  GLY GLY B . n 
A 1 60  PRO 60  60  60  PRO PRO B . n 
A 1 61  ASP 61  61  61  ASP ASP B . n 
A 1 62  LYS 62  62  62  LYS LYS B . n 
A 1 63  ASN 63  63  63  ASN ASN B . n 
A 1 64  LEU 64  64  64  LEU LEU B . n 
A 1 65  THR 65  65  65  THR THR B . n 
A 1 66  GLU 66  66  66  GLU GLU B . n 
A 1 67  ARG 67  67  67  ARG ARG B . n 
A 1 68  GLU 68  68  68  GLU GLU B . n 
A 1 69  VAL 69  69  69  VAL VAL B . n 
A 1 70  PHE 70  70  70  PHE PHE B . n 
A 1 71  ASN 71  71  71  ASN ASN B . n 
A 1 72  GLU 72  72  72  GLU GLU B . n 
A 1 73  ILE 73  73  73  ILE ILE B . n 
A 1 74  TYR 74  74  74  TYR TYR B . n 
A 1 75  PRO 75  75  75  PRO PRO B . n 
A 1 76  VAL 76  76  76  VAL VAL B . n 
A 1 77  TRP 77  77  77  TRP TRP B . n 
A 1 78  THR 78  78  78  THR THR B . n 
A 1 79  TYR 79  79  79  TYR TYR B . n 
A 1 80  SER 80  80  80  SER SER B . n 
A 1 81  TYR 81  81  81  TYR TYR B . n 
A 1 82  LEU 82  82  82  LEU LEU B . n 
A 1 83  VAL 83  83  83  VAL VAL B . n 
A 1 84  LEU 84  84  84  LEU LEU B . n 
A 1 85  LEU 85  85  85  LEU LEU B . n 
A 1 86  PHE 86  86  86  PHE PHE B . n 
A 1 87  PRO 87  87  87  PRO PRO B . n 
A 1 88  VAL 88  88  88  VAL VAL B . n 
A 1 89  PHE 89  89  89  PHE PHE B . n 
A 1 90  LEU 90  90  90  LEU LEU B . n 
A 1 91  ALA 91  91  91  ALA ALA B . n 
A 1 92  THR 92  92  92  THR THR B . n 
A 1 93  ASP 93  93  93  ASP ASP B . n 
A 1 94  TYR 94  94  94  TYR TYR B . n 
A 1 95  LEU 95  95  95  LEU LEU B . n 
A 1 96  ARG 96  96  96  ARG ARG B . n 
A 1 97  TYR 97  97  97  TYR TYR B . n 
A 1 98  LYS 98  98  98  LYS LYS B . n 
A 1 99  PRO 99  99  99  PRO PRO B . n 
A 1 100 VAL 100 100 100 VAL VAL B . n 
A 1 101 VAL 101 101 101 VAL VAL B . n 
A 1 102 LEU 102 102 102 LEU LEU B . n 
A 1 103 LEU 103 103 103 LEU LEU B . n 
A 1 104 GLN 104 104 104 GLN GLN B . n 
A 1 105 GLY 105 105 105 GLY GLY B . n 
A 1 106 LEU 106 106 106 LEU LEU B . n 
A 1 107 SER 107 107 107 SER SER B . n 
A 1 108 LEU 108 108 108 LEU LEU B . n 
A 1 109 ILE 109 109 109 ILE ILE B . n 
A 1 110 VAL 110 110 110 VAL VAL B . n 
A 1 111 THR 111 111 111 THR THR B . n 
A 1 112 TRP 112 112 112 TRP TRP B . n 
A 1 113 PHE 113 113 113 PHE PHE B . n 
A 1 114 MET 114 114 114 MET MET B . n 
A 1 115 LEU 115 115 115 LEU LEU B . n 
A 1 116 LEU 116 116 116 LEU LEU B . n 
A 1 117 TYR 117 117 117 TYR TYR B . n 
A 1 118 ALA 118 118 118 ALA ALA B . n 
A 1 119 GLN 119 119 119 GLN GLN B . n 
A 1 120 GLY 120 120 120 GLY GLY B . n 
A 1 121 LEU 121 121 121 LEU LEU B . n 
A 1 122 LEU 122 122 122 LEU LEU B . n 
A 1 123 ALA 123 123 123 ALA ALA B . n 
A 1 124 ILE 124 124 124 ILE ILE B . n 
A 1 125 GLN 125 125 125 GLN GLN B . n 
A 1 126 PHE 126 126 126 PHE PHE B . n 
A 1 127 LEU 127 127 127 LEU LEU B . n 
A 1 128 GLU 128 128 128 GLU GLU B . n 
A 1 129 PHE 129 129 129 PHE PHE B . n 
A 1 130 PHE 130 130 130 PHE PHE B . n 
A 1 131 TYR 131 131 131 TYR TYR B . n 
A 1 132 GLY 132 132 132 GLY GLY B . n 
A 1 133 ILE 133 133 133 ILE ILE B . n 
A 1 134 ALA 134 134 134 ALA ALA B . n 
A 1 135 THR 135 135 135 THR THR B . n 
A 1 136 ALA 136 136 136 ALA ALA B . n 
A 1 137 THR 137 137 137 THR THR B . n 
A 1 138 GLU 138 138 138 GLU GLU B . n 
A 1 139 ILE 139 139 139 ILE ILE B . n 
A 1 140 ALA 140 140 140 ALA ALA B . n 
A 1 141 TYR 141 141 141 TYR TYR B . n 
A 1 142 TYR 142 142 142 TYR TYR B . n 
A 1 143 SER 143 143 143 SER SER B . n 
A 1 144 TYR 144 144 144 TYR TYR B . n 
A 1 145 ILE 145 145 145 ILE ILE B . n 
A 1 146 TYR 146 146 146 TYR TYR B . n 
A 1 147 SER 147 147 147 SER SER B . n 
A 1 148 VAL 148 148 148 VAL VAL B . n 
A 1 149 VAL 149 149 149 VAL VAL B . n 
A 1 150 ASP 150 150 150 ASP ASP B . n 
A 1 151 LEU 151 151 151 LEU LEU B . n 
A 1 152 GLY 152 152 152 GLY GLY B . n 
A 1 153 MET 153 153 153 MET MET B . n 
A 1 154 TYR 154 154 154 TYR TYR B . n 
A 1 155 GLN 155 155 155 GLN GLN B . n 
A 1 156 LYS 156 156 156 LYS LYS B . n 
A 1 157 VAL 157 157 157 VAL VAL B . n 
A 1 158 THR 158 158 158 THR THR B . n 
A 1 159 SER 159 159 159 SER SER B . n 
A 1 160 TYR 160 160 160 TYR TYR B . n 
A 1 161 CYS 161 161 161 CYS CYS B . n 
A 1 162 ARG 162 162 162 ARG ARG B . n 
A 1 163 SER 163 163 163 SER SER B . n 
A 1 164 ALA 164 164 164 ALA ALA B . n 
A 1 165 THR 165 165 165 THR THR B . n 
A 1 166 LEU 166 166 166 LEU LEU B . n 
A 1 167 VAL 167 167 167 VAL VAL B . n 
A 1 168 GLY 168 168 168 GLY GLY B . n 
A 1 169 PHE 169 169 169 PHE PHE B . n 
A 1 170 THR 170 170 170 THR THR B . n 
A 1 171 VAL 171 171 171 VAL VAL B . n 
A 1 172 GLY 172 172 172 GLY GLY B . n 
A 1 173 SER 173 173 173 SER SER B . n 
A 1 174 VAL 174 174 174 VAL VAL B . n 
A 1 175 LEU 175 175 175 LEU LEU B . n 
A 1 176 GLY 176 176 176 GLY GLY B . n 
A 1 177 GLN 177 177 177 GLN GLN B . n 
A 1 178 ILE 178 178 178 ILE ILE B . n 
A 1 179 LEU 179 179 179 LEU LEU B . n 
A 1 180 VAL 180 180 180 VAL VAL B . n 
A 1 181 SER 181 181 181 SER SER B . n 
A 1 182 VAL 182 182 182 VAL VAL B . n 
A 1 183 ALA 183 183 183 ALA ALA B . n 
A 1 184 GLY 184 184 184 GLY GLY B . n 
A 1 185 TRP 185 185 185 TRP TRP B . n 
A 1 186 SER 186 186 186 SER SER B . n 
A 1 187 LEU 187 187 187 LEU LEU B . n 
A 1 188 PHE 188 188 188 PHE PHE B . n 
A 1 189 SER 189 189 189 SER SER B . n 
A 1 190 LEU 190 190 190 LEU LEU B . n 
A 1 191 ASN 191 191 191 ASN ASN B . n 
A 1 192 VAL 192 192 192 VAL VAL B . n 
A 1 193 ILE 193 193 193 ILE ILE B . n 
A 1 194 SER 194 194 194 SER SER B . n 
A 1 195 LEU 195 195 195 LEU LEU B . n 
A 1 196 THR 196 196 196 THR THR B . n 
A 1 197 CYS 197 197 197 CYS CYS B . n 
A 1 198 VAL 198 198 198 VAL VAL B . n 
A 1 199 SER 199 199 199 SER SER B . n 
A 1 200 VAL 200 200 200 VAL VAL B . n 
A 1 201 ALA 201 201 201 ALA ALA B . n 
A 1 202 PHE 202 202 202 PHE PHE B . n 
A 1 203 ALA 203 203 203 ALA ALA B . n 
A 1 204 VAL 204 204 204 VAL VAL B . n 
A 1 205 ALA 205 205 205 ALA ALA B . n 
A 1 206 TRP 206 206 206 TRP TRP B . n 
A 1 207 PHE 207 207 207 PHE PHE B . n 
A 1 208 LEU 208 208 208 LEU LEU B . n 
A 1 209 PRO 209 209 209 PRO PRO B . n 
A 1 210 MET 210 210 210 MET MET B . n 
A 1 211 PRO 211 211 211 PRO PRO B . n 
A 1 212 GLN 212 212 212 GLN GLN B . n 
A 1 213 LYS 213 213 213 LYS LYS B . n 
A 1 214 SER 214 214 ?   ?   ?   B . n 
A 1 215 LEU 215 215 ?   ?   ?   B . n 
A 1 216 PHE 216 216 ?   ?   ?   B . n 
A 1 217 PHE 217 217 ?   ?   ?   B . n 
A 1 218 HIS 218 218 ?   ?   ?   B . n 
A 1 219 HIS 219 219 ?   ?   ?   B . n 
A 1 220 ILE 220 220 ?   ?   ?   B . n 
A 1 221 PRO 221 221 ?   ?   ?   B . n 
A 1 222 SER 222 222 ?   ?   ?   B . n 
A 1 223 THR 223 223 ?   ?   ?   B . n 
A 1 224 CYS 224 224 ?   ?   ?   B . n 
A 1 225 GLN 225 225 ?   ?   ?   B . n 
A 1 226 ARG 226 226 ?   ?   ?   B . n 
A 1 227 VAL 227 227 ?   ?   ?   B . n 
A 1 228 ASN 228 228 ?   ?   ?   B . n 
A 1 229 GLY 229 229 ?   ?   ?   B . n 
A 1 230 ILE 230 230 ?   ?   ?   B . n 
A 1 231 LYS 231 231 ?   ?   ?   B . n 
A 1 232 VAL 232 232 ?   ?   ?   B . n 
A 1 233 GLN 233 233 ?   ?   ?   B . n 
A 1 234 ASN 234 234 ?   ?   ?   B . n 
A 1 235 GLY 235 235 ?   ?   ?   B . n 
A 1 236 GLY 236 236 ?   ?   ?   B . n 
A 1 237 ILE 237 237 ?   ?   ?   B . n 
A 1 238 VAL 238 238 ?   ?   ?   B . n 
A 1 239 THR 239 239 ?   ?   ?   B . n 
A 1 240 ASP 240 240 ?   ?   ?   B . n 
A 1 241 THR 241 241 ?   ?   ?   B . n 
A 1 242 PRO 242 242 ?   ?   ?   B . n 
A 1 243 ALA 243 243 ?   ?   ?   B . n 
A 1 244 SER 244 244 ?   ?   ?   B . n 
A 1 245 ASN 245 245 ?   ?   ?   B . n 
A 1 246 HIS 246 246 ?   ?   ?   B . n 
A 1 247 LEU 247 247 ?   ?   ?   B . n 
A 1 248 PRO 248 248 ?   ?   ?   B . n 
A 1 249 GLY 249 249 ?   ?   ?   B . n 
A 1 250 TRP 250 250 ?   ?   ?   B . n 
A 1 251 GLU 251 251 ?   ?   ?   B . n 
A 1 252 ASP 252 252 ?   ?   ?   B . n 
A 1 253 ILE 253 253 ?   ?   ?   B . n 
A 1 254 GLU 254 254 ?   ?   ?   B . n 
A 1 255 SER 255 255 ?   ?   ?   B . n 
A 1 256 LYS 256 256 ?   ?   ?   B . n 
A 1 257 ILE 257 257 ?   ?   ?   B . n 
A 1 258 PRO 258 258 ?   ?   ?   B . n 
A 1 259 LEU 259 259 ?   ?   ?   B . n 
A 1 260 ASN 260 260 ?   ?   ?   B . n 
A 1 261 MET 261 261 ?   ?   ?   B . n 
A 1 262 GLU 262 262 ?   ?   ?   B . n 
A 1 263 GLU 263 263 ?   ?   ?   B . n 
A 1 264 PRO 264 264 ?   ?   ?   B . n 
A 1 265 PRO 265 265 ?   ?   ?   B . n 
A 1 266 VAL 266 266 ?   ?   ?   B . n 
A 1 267 GLU 267 267 ?   ?   ?   B . n 
A 1 268 GLU 268 268 ?   ?   ?   B . n 
A 1 269 PRO 269 269 ?   ?   ?   B . n 
A 1 270 GLU 270 270 ?   ?   ?   B . n 
A 1 271 PRO 271 271 ?   ?   ?   B . n 
A 1 272 LYS 272 272 ?   ?   ?   B . n 
A 1 273 PRO 273 273 ?   ?   ?   B . n 
A 1 274 ASP 274 274 ?   ?   ?   B . n 
A 1 275 ARG 275 275 ?   ?   ?   B . n 
A 1 276 LEU 276 276 ?   ?   ?   B . n 
A 1 277 LEU 277 277 ?   ?   ?   B . n 
A 1 278 VAL 278 278 278 VAL VAL B . n 
A 1 279 LEU 279 279 279 LEU LEU B . n 
A 1 280 LYS 280 280 280 LYS LYS B . n 
A 1 281 VAL 281 281 281 VAL VAL B . n 
A 1 282 LEU 282 282 282 LEU LEU B . n 
A 1 283 TRP 283 283 283 TRP TRP B . n 
A 1 284 ASN 284 284 284 ASN ASN B . n 
A 1 285 ASP 285 285 285 ASP ASP B . n 
A 1 286 PHE 286 286 286 PHE PHE B . n 
A 1 287 LEU 287 287 287 LEU LEU B . n 
A 1 288 MET 288 288 288 MET MET B . n 
A 1 289 CYS 289 289 289 CYS CYS B . n 
A 1 290 TYR 290 290 290 TYR TYR B . n 
A 1 291 SER 291 291 291 SER SER B . n 
A 1 292 SER 292 292 292 SER SER B . n 
A 1 293 ARG 293 293 293 ARG ARG B . n 
A 1 294 PRO 294 294 294 PRO PRO B . n 
A 1 295 LEU 295 295 295 LEU LEU B . n 
A 1 296 LEU 296 296 296 LEU LEU B . n 
A 1 297 CYS 297 297 297 CYS CYS B . n 
A 1 298 TRP 298 298 298 TRP TRP B . n 
A 1 299 SER 299 299 299 SER SER B . n 
A 1 300 VAL 300 300 300 VAL VAL B . n 
A 1 301 TRP 301 301 301 TRP TRP B . n 
A 1 302 TRP 302 302 302 TRP TRP B . n 
A 1 303 ALA 303 303 303 ALA ALA B . n 
A 1 304 LEU 304 304 304 LEU LEU B . n 
A 1 305 SER 305 305 305 SER SER B . n 
A 1 306 THR 306 306 306 THR THR B . n 
A 1 307 CYS 307 307 307 CYS CYS B . n 
A 1 308 GLY 308 308 308 GLY GLY B . n 
A 1 309 TYR 309 309 309 TYR TYR B . n 
A 1 310 PHE 310 310 310 PHE PHE B . n 
A 1 311 GLN 311 311 311 GLN GLN B . n 
A 1 312 VAL 312 312 312 VAL VAL B . n 
A 1 313 VAL 313 313 313 VAL VAL B . n 
A 1 314 ASN 314 314 314 ASN ASN B . n 
A 1 315 TYR 315 315 315 TYR TYR B . n 
A 1 316 THR 316 316 316 THR THR B . n 
A 1 317 GLN 317 317 317 GLN GLN B . n 
A 1 318 GLY 318 318 318 GLY GLY B . n 
A 1 319 LEU 319 319 319 LEU LEU B . n 
A 1 320 TRP 320 320 320 TRP TRP B . n 
A 1 321 GLU 321 321 321 GLU GLU B . n 
A 1 322 LYS 322 322 322 LYS LYS B . n 
A 1 323 VAL 323 323 323 VAL VAL B . n 
A 1 324 MET 324 324 324 MET MET B . n 
A 1 325 PRO 325 325 325 PRO PRO B . n 
A 1 326 SER 326 326 326 SER SER B . n 
A 1 327 ARG 327 327 327 ARG ARG B . n 
A 1 328 TYR 328 328 328 TYR TYR B . n 
A 1 329 ALA 329 329 329 ALA ALA B . n 
A 1 330 ALA 330 330 330 ALA ALA B . n 
A 1 331 ILE 331 331 331 ILE ILE B . n 
A 1 332 TYR 332 332 332 TYR TYR B . n 
A 1 333 ASN 333 333 333 ASN ASN B . n 
A 1 334 GLY 334 334 334 GLY GLY B . n 
A 1 335 GLY 335 335 335 GLY GLY B . n 
A 1 336 VAL 336 336 336 VAL VAL B . n 
A 1 337 GLU 337 337 337 GLU GLU B . n 
A 1 338 ALA 338 338 338 ALA ALA B . n 
A 1 339 VAL 339 339 339 VAL VAL B . n 
A 1 340 SER 340 340 340 SER SER B . n 
A 1 341 THR 341 341 341 THR THR B . n 
A 1 342 LEU 342 342 342 LEU LEU B . n 
A 1 343 LEU 343 343 343 LEU LEU B . n 
A 1 344 GLY 344 344 344 GLY GLY B . n 
A 1 345 ALA 345 345 345 ALA ALA B . n 
A 1 346 VAL 346 346 346 VAL VAL B . n 
A 1 347 ALA 347 347 347 ALA ALA B . n 
A 1 348 VAL 348 348 348 VAL VAL B . n 
A 1 349 PHE 349 349 349 PHE PHE B . n 
A 1 350 ALA 350 350 350 ALA ALA B . n 
A 1 351 VAL 351 351 351 VAL VAL B . n 
A 1 352 GLY 352 352 352 GLY GLY B . n 
A 1 353 TYR 353 353 353 TYR TYR B . n 
A 1 354 ILE 354 354 354 ILE ILE B . n 
A 1 355 LYS 355 355 355 LYS LYS B . n 
A 1 356 ILE 356 356 356 ILE ILE B . n 
A 1 357 SER 357 357 357 SER SER B . n 
A 1 358 TRP 358 358 358 TRP TRP B . n 
A 1 359 SER 359 359 359 SER SER B . n 
A 1 360 THR 360 360 360 THR THR B . n 
A 1 361 TRP 361 361 361 TRP TRP B . n 
A 1 362 GLY 362 362 362 GLY GLY B . n 
A 1 363 GLU 363 363 363 GLU GLU B . n 
A 1 364 MET 364 364 364 MET MET B . n 
A 1 365 THR 365 365 365 THR THR B . n 
A 1 366 LEU 366 366 366 LEU LEU B . n 
A 1 367 SER 367 367 367 SER SER B . n 
A 1 368 LEU 368 368 368 LEU LEU B . n 
A 1 369 PHE 369 369 369 PHE PHE B . n 
A 1 370 SER 370 370 370 SER SER B . n 
A 1 371 LEU 371 371 371 LEU LEU B . n 
A 1 372 LEU 372 372 372 LEU LEU B . n 
A 1 373 ILE 373 373 373 ILE ILE B . n 
A 1 374 ALA 374 374 374 ALA ALA B . n 
A 1 375 ALA 375 375 375 ALA ALA B . n 
A 1 376 ALA 376 376 376 ALA ALA B . n 
A 1 377 VAL 377 377 377 VAL VAL B . n 
A 1 378 TYR 378 378 378 TYR TYR B . n 
A 1 379 ILE 379 379 379 ILE ILE B . n 
A 1 380 MET 380 380 380 MET MET B . n 
A 1 381 ASP 381 381 381 ASP ASP B . n 
A 1 382 THR 382 382 382 THR THR B . n 
A 1 383 VAL 383 383 383 VAL VAL B . n 
A 1 384 GLY 384 384 384 GLY GLY B . n 
A 1 385 ASN 385 385 385 ASN ASN B . n 
A 1 386 ILE 386 386 386 ILE ILE B . n 
A 1 387 TRP 387 387 387 TRP TRP B . n 
A 1 388 VAL 388 388 388 VAL VAL B . n 
A 1 389 CYS 389 389 389 CYS CYS B . n 
A 1 390 TYR 390 390 390 TYR TYR B . n 
A 1 391 ALA 391 391 391 ALA ALA B . n 
A 1 392 SER 392 392 392 SER SER B . n 
A 1 393 TYR 393 393 393 TYR TYR B . n 
A 1 394 VAL 394 394 394 VAL VAL B . n 
A 1 395 VAL 395 395 395 VAL VAL B . n 
A 1 396 PHE 396 396 396 PHE PHE B . n 
A 1 397 ARG 397 397 397 ARG ARG B . n 
A 1 398 ILE 398 398 398 ILE ILE B . n 
A 1 399 ILE 399 399 399 ILE ILE B . n 
A 1 400 TYR 400 400 400 TYR TYR B . n 
A 1 401 MET 401 401 401 MET MET B . n 
A 1 402 LEU 402 402 402 LEU LEU B . n 
A 1 403 LEU 403 403 403 LEU LEU B . n 
A 1 404 ILE 404 404 404 ILE ILE B . n 
A 1 405 THR 405 405 405 THR THR B . n 
A 1 406 ILE 406 406 406 ILE ILE B . n 
A 1 407 ALA 407 407 407 ALA ALA B . n 
A 1 408 THR 408 408 408 THR THR B . n 
A 1 409 PHE 409 409 409 PHE PHE B . n 
A 1 410 GLN 410 410 410 GLN GLN B . n 
A 1 411 ILE 411 411 411 ILE ILE B . n 
A 1 412 ALA 412 412 412 ALA ALA B . n 
A 1 413 ALA 413 413 413 ALA ALA B . n 
A 1 414 ASN 414 414 414 ASN ASN B . n 
A 1 415 LEU 415 415 415 LEU LEU B . n 
A 1 416 SER 416 416 416 SER SER B . n 
A 1 417 MET 417 417 417 MET MET B . n 
A 1 418 GLU 418 418 418 GLU GLU B . n 
A 1 419 ARG 419 419 419 ARG ARG B . n 
A 1 420 TYR 420 420 420 TYR TYR B . n 
A 1 421 ALA 421 421 421 ALA ALA B . n 
A 1 422 LEU 422 422 422 LEU LEU B . n 
A 1 423 VAL 423 423 423 VAL VAL B . n 
A 1 424 PHE 424 424 424 PHE PHE B . n 
A 1 425 GLY 425 425 425 GLY GLY B . n 
A 1 426 VAL 426 426 426 VAL VAL B . n 
A 1 427 ASN 427 427 427 ASN ASN B . n 
A 1 428 THR 428 428 428 THR THR B . n 
A 1 429 PHE 429 429 429 PHE PHE B . n 
A 1 430 ILE 430 430 430 ILE ILE B . n 
A 1 431 ALA 431 431 431 ALA ALA B . n 
A 1 432 LEU 432 432 432 LEU LEU B . n 
A 1 433 ALA 433 433 433 ALA ALA B . n 
A 1 434 LEU 434 434 434 LEU LEU B . n 
A 1 435 GLN 435 435 435 GLN GLN B . n 
A 1 436 THR 436 436 436 THR THR B . n 
A 1 437 LEU 437 437 437 LEU LEU B . n 
A 1 438 LEU 438 438 438 LEU LEU B . n 
A 1 439 THR 439 439 439 THR THR B . n 
A 1 440 LEU 440 440 440 LEU LEU B . n 
A 1 441 ILE 441 441 441 ILE ILE B . n 
A 1 442 VAL 442 442 442 VAL VAL B . n 
A 1 443 VAL 443 443 443 VAL VAL B . n 
A 1 444 ASP 444 444 444 ASP ASP B . n 
A 1 445 ALA 445 445 445 ALA ALA B . n 
A 1 446 SER 446 446 446 SER SER B . n 
A 1 447 GLY 447 447 447 GLY GLY B . n 
A 1 448 LEU 448 448 448 LEU LEU B . n 
A 1 449 GLY 449 449 449 GLY GLY B . n 
A 1 450 LEU 450 450 450 LEU LEU B . n 
A 1 451 GLU 451 451 451 GLU GLU B . n 
A 1 452 ILE 452 452 452 ILE ILE B . n 
A 1 453 THR 453 453 453 THR THR B . n 
A 1 454 THR 454 454 454 THR THR B . n 
A 1 455 GLN 455 455 455 GLN GLN B . n 
A 1 456 PHE 456 456 456 PHE PHE B . n 
A 1 457 LEU 457 457 457 LEU LEU B . n 
A 1 458 ILE 458 458 458 ILE ILE B . n 
A 1 459 TYR 459 459 459 TYR TYR B . n 
A 1 460 ALA 460 460 460 ALA ALA B . n 
A 1 461 SER 461 461 461 SER SER B . n 
A 1 462 TYR 462 462 462 TYR TYR B . n 
A 1 463 PHE 463 463 463 PHE PHE B . n 
A 1 464 ALA 464 464 464 ALA ALA B . n 
A 1 465 LEU 465 465 465 LEU LEU B . n 
A 1 466 ILE 466 466 466 ILE ILE B . n 
A 1 467 ALA 467 467 467 ALA ALA B . n 
A 1 468 VAL 468 468 468 VAL VAL B . n 
A 1 469 VAL 469 469 469 VAL VAL B . n 
A 1 470 PHE 470 470 470 PHE PHE B . n 
A 1 471 LEU 471 471 471 LEU LEU B . n 
A 1 472 ALA 472 472 472 ALA ALA B . n 
A 1 473 SER 473 473 473 SER SER B . n 
A 1 474 GLY 474 474 474 GLY GLY B . n 
A 1 475 ALA 475 475 475 ALA ALA B . n 
A 1 476 VAL 476 476 476 VAL VAL B . n 
A 1 477 SER 477 477 477 SER SER B . n 
A 1 478 VAL 478 478 478 VAL VAL B . n 
A 1 479 MET 479 479 479 MET MET B . n 
A 1 480 LYS 480 480 480 LYS LYS B . n 
A 1 481 LYS 481 481 481 LYS LYS B . n 
A 1 482 CYS 482 482 482 CYS CYS B . n 
A 1 483 ARG 483 483 483 ARG ARG B . n 
A 1 484 LYS 484 484 ?   ?   ?   B . n 
A 1 485 LEU 485 485 ?   ?   ?   B . n 
A 1 486 GLU 486 486 ?   ?   ?   B . n 
A 1 487 ASP 487 487 ?   ?   ?   B . n 
A 1 488 PRO 488 488 ?   ?   ?   B . n 
A 1 489 GLN 489 489 ?   ?   ?   B . n 
A 1 490 SER 490 490 ?   ?   ?   B . n 
A 1 491 SER 491 491 ?   ?   ?   B . n 
A 1 492 SER 492 492 ?   ?   ?   B . n 
A 1 493 GLN 493 493 ?   ?   ?   B . n 
A 1 494 VAL 494 494 ?   ?   ?   B . n 
A 1 495 THR 495 495 ?   ?   ?   B . n 
A 1 496 THR 496 496 ?   ?   ?   B . n 
A 1 497 SER 497 497 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UEG 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UEG 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          UEG 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     501 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      UEG 
_pdbx_nonpoly_scheme.auth_mon_id     VB6 
_pdbx_nonpoly_scheme.pdb_strand_id   B 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 B PHE 31  ? CG  ? A PHE 31  CG  
2   1 Y 1 B PHE 31  ? CD1 ? A PHE 31  CD1 
3   1 Y 1 B PHE 31  ? CD2 ? A PHE 31  CD2 
4   1 Y 1 B PHE 31  ? CE1 ? A PHE 31  CE1 
5   1 Y 1 B PHE 31  ? CE2 ? A PHE 31  CE2 
6   1 Y 1 B PHE 31  ? CZ  ? A PHE 31  CZ  
7   1 Y 1 B TYR 117 ? CG  ? A TYR 117 CG  
8   1 Y 1 B TYR 117 ? CD1 ? A TYR 117 CD1 
9   1 Y 1 B TYR 117 ? CD2 ? A TYR 117 CD2 
10  1 Y 1 B TYR 117 ? CE1 ? A TYR 117 CE1 
11  1 Y 1 B TYR 117 ? CE2 ? A TYR 117 CE2 
12  1 Y 1 B TYR 117 ? CZ  ? A TYR 117 CZ  
13  1 Y 1 B TYR 117 ? OH  ? A TYR 117 OH  
14  1 Y 1 B ASP 150 ? CG  ? A ASP 150 CG  
15  1 Y 1 B ASP 150 ? OD1 ? A ASP 150 OD1 
16  1 Y 1 B ASP 150 ? OD2 ? A ASP 150 OD2 
17  1 Y 1 B LEU 151 ? CG  ? A LEU 151 CG  
18  1 Y 1 B LEU 151 ? CD1 ? A LEU 151 CD1 
19  1 Y 1 B LEU 151 ? CD2 ? A LEU 151 CD2 
20  1 Y 1 B MET 153 ? CG  ? A MET 153 CG  
21  1 Y 1 B MET 153 ? SD  ? A MET 153 SD  
22  1 Y 1 B MET 153 ? CE  ? A MET 153 CE  
23  1 Y 1 B TYR 154 ? CG  ? A TYR 154 CG  
24  1 Y 1 B TYR 154 ? CD1 ? A TYR 154 CD1 
25  1 Y 1 B TYR 154 ? CD2 ? A TYR 154 CD2 
26  1 Y 1 B TYR 154 ? CE1 ? A TYR 154 CE1 
27  1 Y 1 B TYR 154 ? CE2 ? A TYR 154 CE2 
28  1 Y 1 B TYR 154 ? CZ  ? A TYR 154 CZ  
29  1 Y 1 B TYR 154 ? OH  ? A TYR 154 OH  
30  1 Y 1 B GLN 155 ? CG  ? A GLN 155 CG  
31  1 Y 1 B GLN 155 ? CD  ? A GLN 155 CD  
32  1 Y 1 B GLN 155 ? OE1 ? A GLN 155 OE1 
33  1 Y 1 B GLN 155 ? NE2 ? A GLN 155 NE2 
34  1 Y 1 B TYR 160 ? CG  ? A TYR 160 CG  
35  1 Y 1 B TYR 160 ? CD1 ? A TYR 160 CD1 
36  1 Y 1 B TYR 160 ? CD2 ? A TYR 160 CD2 
37  1 Y 1 B TYR 160 ? CE1 ? A TYR 160 CE1 
38  1 Y 1 B TYR 160 ? CE2 ? A TYR 160 CE2 
39  1 Y 1 B TYR 160 ? CZ  ? A TYR 160 CZ  
40  1 Y 1 B TYR 160 ? OH  ? A TYR 160 OH  
41  1 Y 1 B GLN 177 ? CG  ? A GLN 177 CG  
42  1 Y 1 B GLN 177 ? CD  ? A GLN 177 CD  
43  1 Y 1 B GLN 177 ? OE1 ? A GLN 177 OE1 
44  1 Y 1 B GLN 177 ? NE2 ? A GLN 177 NE2 
45  1 Y 1 B ILE 178 ? CG1 ? A ILE 178 CG1 
46  1 Y 1 B ILE 178 ? CG2 ? A ILE 178 CG2 
47  1 Y 1 B ILE 178 ? CD1 ? A ILE 178 CD1 
48  1 Y 1 B LEU 179 ? CG  ? A LEU 179 CG  
49  1 Y 1 B LEU 179 ? CD1 ? A LEU 179 CD1 
50  1 Y 1 B LEU 179 ? CD2 ? A LEU 179 CD2 
51  1 Y 1 B VAL 180 ? CG1 ? A VAL 180 CG1 
52  1 Y 1 B VAL 180 ? CG2 ? A VAL 180 CG2 
53  1 Y 1 B SER 181 ? OG  ? A SER 181 OG  
54  1 Y 1 B VAL 182 ? CG1 ? A VAL 182 CG1 
55  1 Y 1 B VAL 182 ? CG2 ? A VAL 182 CG2 
56  1 Y 1 B TRP 185 ? CG  ? A TRP 185 CG  
57  1 Y 1 B TRP 185 ? CD1 ? A TRP 185 CD1 
58  1 Y 1 B TRP 185 ? CD2 ? A TRP 185 CD2 
59  1 Y 1 B TRP 185 ? NE1 ? A TRP 185 NE1 
60  1 Y 1 B TRP 185 ? CE2 ? A TRP 185 CE2 
61  1 Y 1 B TRP 185 ? CE3 ? A TRP 185 CE3 
62  1 Y 1 B TRP 185 ? CZ2 ? A TRP 185 CZ2 
63  1 Y 1 B TRP 185 ? CZ3 ? A TRP 185 CZ3 
64  1 Y 1 B TRP 185 ? CH2 ? A TRP 185 CH2 
65  1 Y 1 B SER 186 ? OG  ? A SER 186 OG  
66  1 Y 1 B LYS 213 ? CG  ? A LYS 213 CG  
67  1 Y 1 B LYS 213 ? CD  ? A LYS 213 CD  
68  1 Y 1 B LYS 213 ? CE  ? A LYS 213 CE  
69  1 Y 1 B LYS 213 ? NZ  ? A LYS 213 NZ  
70  1 Y 1 B VAL 278 ? CG1 ? A VAL 278 CG1 
71  1 Y 1 B VAL 278 ? CG2 ? A VAL 278 CG2 
72  1 Y 1 B LEU 279 ? CG  ? A LEU 279 CG  
73  1 Y 1 B LEU 279 ? CD1 ? A LEU 279 CD1 
74  1 Y 1 B LEU 279 ? CD2 ? A LEU 279 CD2 
75  1 Y 1 B LYS 280 ? CG  ? A LYS 280 CG  
76  1 Y 1 B LYS 280 ? CD  ? A LYS 280 CD  
77  1 Y 1 B LYS 280 ? CE  ? A LYS 280 CE  
78  1 Y 1 B LYS 280 ? NZ  ? A LYS 280 NZ  
79  1 Y 1 B VAL 281 ? CG1 ? A VAL 281 CG1 
80  1 Y 1 B VAL 281 ? CG2 ? A VAL 281 CG2 
81  1 Y 1 B LEU 282 ? CG  ? A LEU 282 CG  
82  1 Y 1 B LEU 282 ? CD1 ? A LEU 282 CD1 
83  1 Y 1 B LEU 282 ? CD2 ? A LEU 282 CD2 
84  1 Y 1 B TRP 283 ? CG  ? A TRP 283 CG  
85  1 Y 1 B TRP 283 ? CD1 ? A TRP 283 CD1 
86  1 Y 1 B TRP 283 ? CD2 ? A TRP 283 CD2 
87  1 Y 1 B TRP 283 ? NE1 ? A TRP 283 NE1 
88  1 Y 1 B TRP 283 ? CE2 ? A TRP 283 CE2 
89  1 Y 1 B TRP 283 ? CE3 ? A TRP 283 CE3 
90  1 Y 1 B TRP 283 ? CZ2 ? A TRP 283 CZ2 
91  1 Y 1 B TRP 283 ? CZ3 ? A TRP 283 CZ3 
92  1 Y 1 B TRP 283 ? CH2 ? A TRP 283 CH2 
93  1 Y 1 B ASN 284 ? CG  ? A ASN 284 CG  
94  1 Y 1 B ASN 284 ? OD1 ? A ASN 284 OD1 
95  1 Y 1 B ASN 284 ? ND2 ? A ASN 284 ND2 
96  1 Y 1 B ASP 285 ? CG  ? A ASP 285 CG  
97  1 Y 1 B ASP 285 ? OD1 ? A ASP 285 OD1 
98  1 Y 1 B ASP 285 ? OD2 ? A ASP 285 OD2 
99  1 Y 1 B PHE 286 ? CG  ? A PHE 286 CG  
100 1 Y 1 B PHE 286 ? CD1 ? A PHE 286 CD1 
101 1 Y 1 B PHE 286 ? CD2 ? A PHE 286 CD2 
102 1 Y 1 B PHE 286 ? CE1 ? A PHE 286 CE1 
103 1 Y 1 B PHE 286 ? CE2 ? A PHE 286 CE2 
104 1 Y 1 B PHE 286 ? CZ  ? A PHE 286 CZ  
105 1 Y 1 B LEU 287 ? CG  ? A LEU 287 CG  
106 1 Y 1 B LEU 287 ? CD1 ? A LEU 287 CD1 
107 1 Y 1 B LEU 287 ? CD2 ? A LEU 287 CD2 
108 1 Y 1 B MET 288 ? CG  ? A MET 288 CG  
109 1 Y 1 B MET 288 ? SD  ? A MET 288 SD  
110 1 Y 1 B MET 288 ? CE  ? A MET 288 CE  
111 1 Y 1 B CYS 289 ? SG  ? A CYS 289 SG  
112 1 Y 1 B TYR 290 ? CG  ? A TYR 290 CG  
113 1 Y 1 B TYR 290 ? CD1 ? A TYR 290 CD1 
114 1 Y 1 B TYR 290 ? CD2 ? A TYR 290 CD2 
115 1 Y 1 B TYR 290 ? CE1 ? A TYR 290 CE1 
116 1 Y 1 B TYR 290 ? CE2 ? A TYR 290 CE2 
117 1 Y 1 B TYR 290 ? CZ  ? A TYR 290 CZ  
118 1 Y 1 B TYR 290 ? OH  ? A TYR 290 OH  
119 1 Y 1 B SER 291 ? OG  ? A SER 291 OG  
120 1 Y 1 B SER 292 ? OG  ? A SER 292 OG  
121 1 Y 1 B ARG 293 ? CG  ? A ARG 293 CG  
122 1 Y 1 B ARG 293 ? CD  ? A ARG 293 CD  
123 1 Y 1 B ARG 293 ? NE  ? A ARG 293 NE  
124 1 Y 1 B ARG 293 ? CZ  ? A ARG 293 CZ  
125 1 Y 1 B ARG 293 ? NH1 ? A ARG 293 NH1 
126 1 Y 1 B ARG 293 ? NH2 ? A ARG 293 NH2 
127 1 Y 1 B PRO 294 ? CG  ? A PRO 294 CG  
128 1 Y 1 B PRO 294 ? CD  ? A PRO 294 CD  
129 1 Y 1 B LEU 295 ? CG  ? A LEU 295 CG  
130 1 Y 1 B LEU 295 ? CD1 ? A LEU 295 CD1 
131 1 Y 1 B LEU 295 ? CD2 ? A LEU 295 CD2 
132 1 Y 1 B MET 324 ? CG  ? A MET 324 CG  
133 1 Y 1 B MET 324 ? SD  ? A MET 324 SD  
134 1 Y 1 B MET 324 ? CE  ? A MET 324 CE  
135 1 Y 1 B ARG 327 ? CG  ? A ARG 327 CG  
136 1 Y 1 B ARG 327 ? CD  ? A ARG 327 CD  
137 1 Y 1 B ARG 327 ? NE  ? A ARG 327 NE  
138 1 Y 1 B ARG 327 ? CZ  ? A ARG 327 CZ  
139 1 Y 1 B ARG 327 ? NH1 ? A ARG 327 NH1 
140 1 Y 1 B ARG 327 ? NH2 ? A ARG 327 NH2 
141 1 Y 1 B TYR 328 ? CG  ? A TYR 328 CG  
142 1 Y 1 B TYR 328 ? CD1 ? A TYR 328 CD1 
143 1 Y 1 B TYR 328 ? CD2 ? A TYR 328 CD2 
144 1 Y 1 B TYR 328 ? CE1 ? A TYR 328 CE1 
145 1 Y 1 B TYR 328 ? CE2 ? A TYR 328 CE2 
146 1 Y 1 B TYR 328 ? CZ  ? A TYR 328 CZ  
147 1 Y 1 B TYR 328 ? OH  ? A TYR 328 OH  
148 1 Y 1 B VAL 348 ? CG1 ? A VAL 348 CG1 
149 1 Y 1 B VAL 348 ? CG2 ? A VAL 348 CG2 
150 1 Y 1 B PHE 349 ? CG  ? A PHE 349 CG  
151 1 Y 1 B PHE 349 ? CD1 ? A PHE 349 CD1 
152 1 Y 1 B PHE 349 ? CD2 ? A PHE 349 CD2 
153 1 Y 1 B PHE 349 ? CE1 ? A PHE 349 CE1 
154 1 Y 1 B PHE 349 ? CE2 ? A PHE 349 CE2 
155 1 Y 1 B PHE 349 ? CZ  ? A PHE 349 CZ  
156 1 Y 1 B VAL 351 ? CG1 ? A VAL 351 CG1 
157 1 Y 1 B VAL 351 ? CG2 ? A VAL 351 CG2 
158 1 Y 1 B TYR 353 ? CG  ? A TYR 353 CG  
159 1 Y 1 B TYR 353 ? CD1 ? A TYR 353 CD1 
160 1 Y 1 B TYR 353 ? CD2 ? A TYR 353 CD2 
161 1 Y 1 B TYR 353 ? CE1 ? A TYR 353 CE1 
162 1 Y 1 B TYR 353 ? CE2 ? A TYR 353 CE2 
163 1 Y 1 B TYR 353 ? CZ  ? A TYR 353 CZ  
164 1 Y 1 B TYR 353 ? OH  ? A TYR 353 OH  
165 1 Y 1 B ILE 354 ? CG1 ? A ILE 354 CG1 
166 1 Y 1 B ILE 354 ? CG2 ? A ILE 354 CG2 
167 1 Y 1 B ILE 354 ? CD1 ? A ILE 354 CD1 
168 1 Y 1 B LYS 355 ? CG  ? A LYS 355 CG  
169 1 Y 1 B LYS 355 ? CD  ? A LYS 355 CD  
170 1 Y 1 B LYS 355 ? CE  ? A LYS 355 CE  
171 1 Y 1 B LYS 355 ? NZ  ? A LYS 355 NZ  
172 1 Y 1 B ILE 356 ? CG1 ? A ILE 356 CG1 
173 1 Y 1 B ILE 356 ? CG2 ? A ILE 356 CG2 
174 1 Y 1 B ILE 356 ? CD1 ? A ILE 356 CD1 
175 1 Y 1 B SER 357 ? OG  ? A SER 357 OG  
176 1 Y 1 B TRP 358 ? CG  ? A TRP 358 CG  
177 1 Y 1 B TRP 358 ? CD1 ? A TRP 358 CD1 
178 1 Y 1 B TRP 358 ? CD2 ? A TRP 358 CD2 
179 1 Y 1 B TRP 358 ? NE1 ? A TRP 358 NE1 
180 1 Y 1 B TRP 358 ? CE2 ? A TRP 358 CE2 
181 1 Y 1 B TRP 358 ? CE3 ? A TRP 358 CE3 
182 1 Y 1 B TRP 358 ? CZ2 ? A TRP 358 CZ2 
183 1 Y 1 B TRP 358 ? CZ3 ? A TRP 358 CZ3 
184 1 Y 1 B TRP 358 ? CH2 ? A TRP 358 CH2 
185 1 Y 1 B SER 359 ? OG  ? A SER 359 OG  
186 1 Y 1 B THR 360 ? OG1 ? A THR 360 OG1 
187 1 Y 1 B THR 360 ? CG2 ? A THR 360 CG2 
188 1 Y 1 B TRP 361 ? CG  ? A TRP 361 CG  
189 1 Y 1 B TRP 361 ? CD1 ? A TRP 361 CD1 
190 1 Y 1 B TRP 361 ? CD2 ? A TRP 361 CD2 
191 1 Y 1 B TRP 361 ? NE1 ? A TRP 361 NE1 
192 1 Y 1 B TRP 361 ? CE2 ? A TRP 361 CE2 
193 1 Y 1 B TRP 361 ? CE3 ? A TRP 361 CE3 
194 1 Y 1 B TRP 361 ? CZ2 ? A TRP 361 CZ2 
195 1 Y 1 B TRP 361 ? CZ3 ? A TRP 361 CZ3 
196 1 Y 1 B TRP 361 ? CH2 ? A TRP 361 CH2 
197 1 Y 1 B GLU 363 ? CG  ? A GLU 363 CG  
198 1 Y 1 B GLU 363 ? CD  ? A GLU 363 CD  
199 1 Y 1 B GLU 363 ? OE1 ? A GLU 363 OE1 
200 1 Y 1 B GLU 363 ? OE2 ? A GLU 363 OE2 
201 1 Y 1 B PHE 369 ? CG  ? A PHE 369 CG  
202 1 Y 1 B PHE 369 ? CD1 ? A PHE 369 CD1 
203 1 Y 1 B PHE 369 ? CD2 ? A PHE 369 CD2 
204 1 Y 1 B PHE 369 ? CE1 ? A PHE 369 CE1 
205 1 Y 1 B PHE 369 ? CE2 ? A PHE 369 CE2 
206 1 Y 1 B PHE 369 ? CZ  ? A PHE 369 CZ  
207 1 Y 1 B ASN 414 ? CG  ? A ASN 414 CG  
208 1 Y 1 B ASN 414 ? OD1 ? A ASN 414 OD1 
209 1 Y 1 B ASN 414 ? ND2 ? A ASN 414 ND2 
210 1 Y 1 B LEU 415 ? CG  ? A LEU 415 CG  
211 1 Y 1 B LEU 415 ? CD1 ? A LEU 415 CD1 
212 1 Y 1 B LEU 415 ? CD2 ? A LEU 415 CD2 
213 1 Y 1 B SER 416 ? OG  ? A SER 416 OG  
214 1 Y 1 B MET 417 ? CG  ? A MET 417 CG  
215 1 Y 1 B MET 417 ? SD  ? A MET 417 SD  
216 1 Y 1 B MET 417 ? CE  ? A MET 417 CE  
217 1 Y 1 B GLU 418 ? CG  ? A GLU 418 CG  
218 1 Y 1 B GLU 418 ? CD  ? A GLU 418 CD  
219 1 Y 1 B GLU 418 ? OE1 ? A GLU 418 OE1 
220 1 Y 1 B GLU 418 ? OE2 ? A GLU 418 OE2 
221 1 Y 1 B ARG 419 ? CG  ? A ARG 419 CG  
222 1 Y 1 B ARG 419 ? CD  ? A ARG 419 CD  
223 1 Y 1 B ARG 419 ? NE  ? A ARG 419 NE  
224 1 Y 1 B ARG 419 ? CZ  ? A ARG 419 CZ  
225 1 Y 1 B ARG 419 ? NH1 ? A ARG 419 NH1 
226 1 Y 1 B ARG 419 ? NH2 ? A ARG 419 NH2 
227 1 Y 1 B PHE 424 ? CG  ? A PHE 424 CG  
228 1 Y 1 B PHE 424 ? CD1 ? A PHE 424 CD1 
229 1 Y 1 B PHE 424 ? CD2 ? A PHE 424 CD2 
230 1 Y 1 B PHE 424 ? CE1 ? A PHE 424 CE1 
231 1 Y 1 B PHE 424 ? CE2 ? A PHE 424 CE2 
232 1 Y 1 B PHE 424 ? CZ  ? A PHE 424 CZ  
233 1 Y 1 B PHE 470 ? CG  ? A PHE 470 CG  
234 1 Y 1 B PHE 470 ? CD1 ? A PHE 470 CD1 
235 1 Y 1 B PHE 470 ? CD2 ? A PHE 470 CD2 
236 1 Y 1 B PHE 470 ? CE1 ? A PHE 470 CE1 
237 1 Y 1 B PHE 470 ? CE2 ? A PHE 470 CE2 
238 1 Y 1 B PHE 470 ? CZ  ? A PHE 470 CZ  
239 1 Y 1 B VAL 476 ? CG1 ? A VAL 476 CG1 
240 1 Y 1 B VAL 476 ? CG2 ? A VAL 476 CG2 
241 1 Y 1 B SER 477 ? OG  ? A SER 477 OG  
242 1 Y 1 B VAL 478 ? CG1 ? A VAL 478 CG1 
243 1 Y 1 B VAL 478 ? CG2 ? A VAL 478 CG2 
244 1 Y 1 B MET 479 ? CG  ? A MET 479 CG  
245 1 Y 1 B MET 479 ? SD  ? A MET 479 SD  
246 1 Y 1 B MET 479 ? CE  ? A MET 479 CE  
247 1 Y 1 B LYS 480 ? CG  ? A LYS 480 CG  
248 1 Y 1 B LYS 480 ? CD  ? A LYS 480 CD  
249 1 Y 1 B LYS 480 ? CE  ? A LYS 480 CE  
250 1 Y 1 B LYS 480 ? NZ  ? A LYS 480 NZ  
251 1 Y 1 B LYS 481 ? CG  ? A LYS 481 CG  
252 1 Y 1 B LYS 481 ? CD  ? A LYS 481 CD  
253 1 Y 1 B LYS 481 ? CE  ? A LYS 481 CE  
254 1 Y 1 B LYS 481 ? NZ  ? A LYS 481 NZ  
255 1 Y 1 B CYS 482 ? SG  ? A CYS 482 SG  
256 1 Y 1 B ARG 483 ? CG  ? A ARG 483 CG  
257 1 Y 1 B ARG 483 ? CD  ? A ARG 483 CD  
258 1 Y 1 B ARG 483 ? NE  ? A ARG 483 NE  
259 1 Y 1 B ARG 483 ? CZ  ? A ARG 483 CZ  
260 1 Y 1 B ARG 483 ? NH1 ? A ARG 483 NH1 
261 1 Y 1 B ARG 483 ? NH2 ? A ARG 483 NH2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Z80 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Z80 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Z80 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8Z80 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 2895 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.709 ? 3983 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 5.082 ? 416  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.044 ? 497  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.006 ? 483  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8Z80 
_struct.title                        'SLC19A2-Pyridoxine inward structure' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Z80 
_struct_keywords.text            'Thiamine transporter, MFS, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    S19A2_HUMAN 
_struct_ref.pdbx_db_accession          O60779 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYS
YLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSY
CRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTD
TPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLW
EKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIY
MLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMK
KCRKLEDPQSSSQVTTS
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8Z80 
_struct_ref_seq.pdbx_strand_id                B 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 497 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O60779 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  497 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       497 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PHE A 31  ? LEU A 46  ? PHE B 31  LEU B 46  1 ? 16 
HELX_P HELX_P2  AA2 LEU A 53  ? GLY A 59  ? LEU B 53  GLY B 59  1 ? 7  
HELX_P HELX_P3  AA3 THR A 65  ? LEU A 95  ? THR B 65  LEU B 95  1 ? 31 
HELX_P HELX_P4  AA4 PRO A 99  ? TYR A 117 ? PRO B 99  TYR B 117 1 ? 19 
HELX_P HELX_P5  AA5 LEU A 121 ? ALA A 136 ? LEU B 121 ALA B 136 1 ? 16 
HELX_P HELX_P6  AA6 THR A 137 ? ILE A 145 ? THR B 137 ILE B 145 1 ? 9  
HELX_P HELX_P7  AA7 TYR A 146 ? VAL A 148 ? TYR B 146 VAL B 148 5 ? 3  
HELX_P HELX_P8  AA8 ASP A 150 ? SER A 181 ? ASP B 150 SER B 181 1 ? 32 
HELX_P HELX_P9  AA9 SER A 186 ? TRP A 206 ? SER B 186 TRP B 206 1 ? 21 
HELX_P HELX_P10 AB1 LYS A 280 ? MET A 288 ? LYS B 280 MET B 288 1 ? 9  
HELX_P HELX_P11 AB2 CYS A 289 ? SER A 291 ? CYS B 289 SER B 291 5 ? 3  
HELX_P HELX_P12 AB3 SER A 292 ? CYS A 297 ? SER B 292 CYS B 297 1 ? 6  
HELX_P HELX_P13 AB4 TRP A 298 ? MET A 324 ? TRP B 298 MET B 324 1 ? 27 
HELX_P HELX_P14 AB5 TYR A 332 ? GLY A 352 ? TYR B 332 GLY B 352 1 ? 21 
HELX_P HELX_P15 AB6 TRP A 361 ? THR A 382 ? TRP B 361 THR B 382 1 ? 22 
HELX_P HELX_P16 AB7 ILE A 386 ? LEU A 415 ? ILE B 386 LEU B 415 1 ? 30 
HELX_P HELX_P17 AB8 ARG A 419 ? VAL A 442 ? ARG B 419 VAL B 442 1 ? 24 
HELX_P HELX_P18 AB9 ILE A 452 ? LEU A 457 ? ILE B 452 LEU B 457 5 ? 6  
HELX_P HELX_P19 AC1 ILE A 458 ? CYS A 482 ? ILE B 458 CYS B 482 1 ? 25 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   8Z80 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO B 60  ? ? -56.10  -6.24  
2 1 SER B 291 ? ? -92.07  52.48  
3 1 TRP B 298 ? ? 72.51   -10.68 
4 1 TYR B 332 ? ? -101.81 68.58  
5 1 TRP B 361 ? ? -140.10 34.16  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8Z80 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8Z80 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.7 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               157332 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            6.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'SLC19A3-Thiamine complex' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8Z80 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8Z80 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8Z80 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 B MET 1   ? A MET 1   
2   1 Y 1 B ASP 2   ? A ASP 2   
3   1 Y 1 B VAL 3   ? A VAL 3   
4   1 Y 1 B PRO 4   ? A PRO 4   
5   1 Y 1 B GLY 5   ? A GLY 5   
6   1 Y 1 B PRO 6   ? A PRO 6   
7   1 Y 1 B VAL 7   ? A VAL 7   
8   1 Y 1 B SER 8   ? A SER 8   
9   1 Y 1 B ARG 9   ? A ARG 9   
10  1 Y 1 B ARG 10  ? A ARG 10  
11  1 Y 1 B ALA 11  ? A ALA 11  
12  1 Y 1 B ALA 12  ? A ALA 12  
13  1 Y 1 B ALA 13  ? A ALA 13  
14  1 Y 1 B ALA 14  ? A ALA 14  
15  1 Y 1 B ALA 15  ? A ALA 15  
16  1 Y 1 B ALA 16  ? A ALA 16  
17  1 Y 1 B THR 17  ? A THR 17  
18  1 Y 1 B VAL 18  ? A VAL 18  
19  1 Y 1 B LEU 19  ? A LEU 19  
20  1 Y 1 B LEU 20  ? A LEU 20  
21  1 Y 1 B ARG 21  ? A ARG 21  
22  1 Y 1 B THR 22  ? A THR 22  
23  1 Y 1 B ALA 23  ? A ALA 23  
24  1 Y 1 B ARG 24  ? A ARG 24  
25  1 Y 1 B VAL 25  ? A VAL 25  
26  1 Y 1 B ARG 26  ? A ARG 26  
27  1 Y 1 B ARG 27  ? A ARG 27  
28  1 Y 1 B GLU 28  ? A GLU 28  
29  1 Y 1 B CYS 29  ? A CYS 29  
30  1 Y 1 B TRP 30  ? A TRP 30  
31  1 Y 1 B SER 214 ? A SER 214 
32  1 Y 1 B LEU 215 ? A LEU 215 
33  1 Y 1 B PHE 216 ? A PHE 216 
34  1 Y 1 B PHE 217 ? A PHE 217 
35  1 Y 1 B HIS 218 ? A HIS 218 
36  1 Y 1 B HIS 219 ? A HIS 219 
37  1 Y 1 B ILE 220 ? A ILE 220 
38  1 Y 1 B PRO 221 ? A PRO 221 
39  1 Y 1 B SER 222 ? A SER 222 
40  1 Y 1 B THR 223 ? A THR 223 
41  1 Y 1 B CYS 224 ? A CYS 224 
42  1 Y 1 B GLN 225 ? A GLN 225 
43  1 Y 1 B ARG 226 ? A ARG 226 
44  1 Y 1 B VAL 227 ? A VAL 227 
45  1 Y 1 B ASN 228 ? A ASN 228 
46  1 Y 1 B GLY 229 ? A GLY 229 
47  1 Y 1 B ILE 230 ? A ILE 230 
48  1 Y 1 B LYS 231 ? A LYS 231 
49  1 Y 1 B VAL 232 ? A VAL 232 
50  1 Y 1 B GLN 233 ? A GLN 233 
51  1 Y 1 B ASN 234 ? A ASN 234 
52  1 Y 1 B GLY 235 ? A GLY 235 
53  1 Y 1 B GLY 236 ? A GLY 236 
54  1 Y 1 B ILE 237 ? A ILE 237 
55  1 Y 1 B VAL 238 ? A VAL 238 
56  1 Y 1 B THR 239 ? A THR 239 
57  1 Y 1 B ASP 240 ? A ASP 240 
58  1 Y 1 B THR 241 ? A THR 241 
59  1 Y 1 B PRO 242 ? A PRO 242 
60  1 Y 1 B ALA 243 ? A ALA 243 
61  1 Y 1 B SER 244 ? A SER 244 
62  1 Y 1 B ASN 245 ? A ASN 245 
63  1 Y 1 B HIS 246 ? A HIS 246 
64  1 Y 1 B LEU 247 ? A LEU 247 
65  1 Y 1 B PRO 248 ? A PRO 248 
66  1 Y 1 B GLY 249 ? A GLY 249 
67  1 Y 1 B TRP 250 ? A TRP 250 
68  1 Y 1 B GLU 251 ? A GLU 251 
69  1 Y 1 B ASP 252 ? A ASP 252 
70  1 Y 1 B ILE 253 ? A ILE 253 
71  1 Y 1 B GLU 254 ? A GLU 254 
72  1 Y 1 B SER 255 ? A SER 255 
73  1 Y 1 B LYS 256 ? A LYS 256 
74  1 Y 1 B ILE 257 ? A ILE 257 
75  1 Y 1 B PRO 258 ? A PRO 258 
76  1 Y 1 B LEU 259 ? A LEU 259 
77  1 Y 1 B ASN 260 ? A ASN 260 
78  1 Y 1 B MET 261 ? A MET 261 
79  1 Y 1 B GLU 262 ? A GLU 262 
80  1 Y 1 B GLU 263 ? A GLU 263 
81  1 Y 1 B PRO 264 ? A PRO 264 
82  1 Y 1 B PRO 265 ? A PRO 265 
83  1 Y 1 B VAL 266 ? A VAL 266 
84  1 Y 1 B GLU 267 ? A GLU 267 
85  1 Y 1 B GLU 268 ? A GLU 268 
86  1 Y 1 B PRO 269 ? A PRO 269 
87  1 Y 1 B GLU 270 ? A GLU 270 
88  1 Y 1 B PRO 271 ? A PRO 271 
89  1 Y 1 B LYS 272 ? A LYS 272 
90  1 Y 1 B PRO 273 ? A PRO 273 
91  1 Y 1 B ASP 274 ? A ASP 274 
92  1 Y 1 B ARG 275 ? A ARG 275 
93  1 Y 1 B LEU 276 ? A LEU 276 
94  1 Y 1 B LEU 277 ? A LEU 277 
95  1 Y 1 B LYS 484 ? A LYS 484 
96  1 Y 1 B LEU 485 ? A LEU 485 
97  1 Y 1 B GLU 486 ? A GLU 486 
98  1 Y 1 B ASP 487 ? A ASP 487 
99  1 Y 1 B PRO 488 ? A PRO 488 
100 1 Y 1 B GLN 489 ? A GLN 489 
101 1 Y 1 B SER 490 ? A SER 490 
102 1 Y 1 B SER 491 ? A SER 491 
103 1 Y 1 B SER 492 ? A SER 492 
104 1 Y 1 B GLN 493 ? A GLN 493 
105 1 Y 1 B VAL 494 ? A VAL 494 
106 1 Y 1 B THR 495 ? A THR 495 
107 1 Y 1 B THR 496 ? A THR 496 
108 1 Y 1 B SER 497 ? A SER 497 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
UEG OP4  O N N 369 
UEG C5A  C N N 370 
UEG C5   C Y N 371 
UEG C6   C Y N 372 
UEG N1   N Y N 373 
UEG C2   C Y N 374 
UEG C3   C Y N 375 
UEG C4   C Y N 376 
UEG C4A  C N N 377 
UEG O4A  O N N 378 
UEG O3   O N N 379 
UEG C2A  C N N 380 
UEG HP4  H N N 381 
UEG H5A  H N N 382 
UEG H5B  H N N 383 
UEG H6   H N N 384 
UEG H2A  H N N 385 
UEG H2B  H N N 386 
UEG H2C  H N N 387 
UEG H3   H N N 388 
UEG H4A  H N N 389 
UEG H4B  H N N 390 
UEG H5   H N N 391 
VAL N    N N N 392 
VAL CA   C N S 393 
VAL C    C N N 394 
VAL O    O N N 395 
VAL CB   C N N 396 
VAL CG1  C N N 397 
VAL CG2  C N N 398 
VAL OXT  O N N 399 
VAL H    H N N 400 
VAL H2   H N N 401 
VAL HA   H N N 402 
VAL HB   H N N 403 
VAL HG11 H N N 404 
VAL HG12 H N N 405 
VAL HG13 H N N 406 
VAL HG21 H N N 407 
VAL HG22 H N N 408 
VAL HG23 H N N 409 
VAL HXT  H N N 410 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
UEG OP4 C5A  sing N N 356 
UEG C5A C5   sing N N 357 
UEG C5  C6   sing Y N 358 
UEG C5  C4   doub Y N 359 
UEG C6  N1   doub Y N 360 
UEG N1  C2   sing Y N 361 
UEG C2  C3   doub Y N 362 
UEG C2  C2A  sing N N 363 
UEG C3  C4   sing Y N 364 
UEG C3  O3   sing N N 365 
UEG C4  C4A  sing N N 366 
UEG C4A O4A  sing N N 367 
UEG C4A H4A  sing N N 368 
UEG C4A H4B  sing N N 369 
UEG OP4 HP4  sing N N 370 
UEG C5A H5A  sing N N 371 
UEG C5A H5B  sing N N 372 
UEG C6  H6   sing N N 373 
UEG C2A H2A  sing N N 374 
UEG C2A H2B  sing N N 375 
UEG C2A H2C  sing N N 376 
UEG O3  H3   sing N N 377 
UEG O4A H5   sing N N 378 
VAL N   CA   sing N N 379 
VAL N   H    sing N N 380 
VAL N   H2   sing N N 381 
VAL CA  C    sing N N 382 
VAL CA  CB   sing N N 383 
VAL CA  HA   sing N N 384 
VAL C   O    doub N N 385 
VAL C   OXT  sing N N 386 
VAL CB  CG1  sing N N 387 
VAL CB  CG2  sing N N 388 
VAL CB  HB   sing N N 389 
VAL CG1 HG11 sing N N 390 
VAL CG1 HG12 sing N N 391 
VAL CG1 HG13 sing N N 392 
VAL CG2 HG21 sing N N 393 
VAL CG2 HG22 sing N N 394 
VAL CG2 HG23 sing N N 395 
VAL OXT HXT  sing N N 396 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-21 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8Z80 
_em_admin.last_update        2025-01-08 
_em_admin.map_release_date   2025-01-08 
_em_admin.title              'SLC19A2-Pyridoxine inward structure' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8Z80 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 31  ? 134.580 147.582 122.893 1.00 45.61  ? 31  PHE B N   1 
ATOM   2    C CA  . PHE A 1 31  ? 134.818 146.207 123.310 1.00 45.61  ? 31  PHE B CA  1 
ATOM   3    C C   . PHE A 1 31  ? 136.292 145.970 123.598 1.00 45.61  ? 31  PHE B C   1 
ATOM   4    O O   . PHE A 1 31  ? 136.644 145.306 124.572 1.00 45.61  ? 31  PHE B O   1 
ATOM   5    C CB  . PHE A 1 31  ? 134.334 145.232 122.237 1.00 45.61  ? 31  PHE B CB  1 
ATOM   6    N N   . LEU A 1 32  ? 137.147 146.505 122.728 1.00 50.37  ? 32  LEU B N   1 
ATOM   7    C CA  . LEU A 1 32  ? 138.583 146.279 122.868 1.00 50.37  ? 32  LEU B CA  1 
ATOM   8    C C   . LEU A 1 32  ? 139.175 146.905 124.130 1.00 50.37  ? 32  LEU B C   1 
ATOM   9    O O   . LEU A 1 32  ? 140.008 146.241 124.773 1.00 50.37  ? 32  LEU B O   1 
ATOM   10   C CB  . LEU A 1 32  ? 139.303 146.755 121.596 1.00 50.37  ? 32  LEU B CB  1 
ATOM   11   C CG  . LEU A 1 32  ? 140.754 146.321 121.398 1.00 50.37  ? 32  LEU B CG  1 
ATOM   12   C CD1 . LEU A 1 32  ? 140.829 144.829 121.122 1.00 50.37  ? 32  LEU B CD1 1 
ATOM   13   C CD2 . LEU A 1 32  ? 141.389 147.110 120.266 1.00 50.37  ? 32  LEU B CD2 1 
ATOM   14   N N   . PRO A 1 33  ? 138.843 148.146 124.525 1.00 49.46  ? 33  PRO B N   1 
ATOM   15   C CA  . PRO A 1 33  ? 139.285 148.606 125.853 1.00 49.46  ? 33  PRO B CA  1 
ATOM   16   C C   . PRO A 1 33  ? 138.860 147.684 126.982 1.00 49.46  ? 33  PRO B C   1 
ATOM   17   O O   . PRO A 1 33  ? 139.641 147.452 127.910 1.00 49.46  ? 33  PRO B O   1 
ATOM   18   C CB  . PRO A 1 33  ? 138.622 149.985 125.990 1.00 49.46  ? 33  PRO B CB  1 
ATOM   19   C CG  . PRO A 1 33  ? 138.217 150.396 124.619 1.00 49.46  ? 33  PRO B CG  1 
ATOM   20   C CD  . PRO A 1 33  ? 138.516 149.291 123.657 1.00 49.46  ? 33  PRO B CD  1 
ATOM   21   N N   . THR A 1 34  ? 137.638 147.146 126.929 1.00 47.12  ? 34  THR B N   1 
ATOM   22   C CA  . THR A 1 34  ? 137.177 146.250 127.986 1.00 47.12  ? 34  THR B CA  1 
ATOM   23   C C   . THR A 1 34  ? 137.961 144.945 127.984 1.00 47.12  ? 34  THR B C   1 
ATOM   24   O O   . THR A 1 34  ? 138.266 144.391 129.048 1.00 47.12  ? 34  THR B O   1 
ATOM   25   C CB  . THR A 1 34  ? 135.683 145.976 127.827 1.00 47.12  ? 34  THR B CB  1 
ATOM   26   O OG1 . THR A 1 34  ? 134.984 147.216 127.663 1.00 47.12  ? 34  THR B OG1 1 
ATOM   27   C CG2 . THR A 1 34  ? 135.144 145.256 129.052 1.00 47.12  ? 34  THR B CG2 1 
ATOM   28   N N   . ALA A 1 35  ? 138.280 144.432 126.794 1.00 48.88  ? 35  ALA B N   1 
ATOM   29   C CA  . ALA A 1 35  ? 139.122 143.245 126.703 1.00 48.88  ? 35  ALA B CA  1 
ATOM   30   C C   . ALA A 1 35  ? 140.503 143.519 127.282 1.00 48.88  ? 35  ALA B C   1 
ATOM   31   O O   . ALA A 1 35  ? 141.093 142.661 127.948 1.00 48.88  ? 35  ALA B O   1 
ATOM   32   C CB  . ALA A 1 35  ? 139.223 142.783 125.250 1.00 48.88  ? 35  ALA B CB  1 
ATOM   33   N N   . LEU A 1 36  ? 141.030 144.719 127.040 1.00 51.26  ? 36  LEU B N   1 
ATOM   34   C CA  . LEU A 1 36  ? 142.295 145.105 127.654 1.00 51.26  ? 36  LEU B CA  1 
ATOM   35   C C   . LEU A 1 36  ? 142.168 145.161 129.171 1.00 51.26  ? 36  LEU B C   1 
ATOM   36   O O   . LEU A 1 36  ? 143.085 144.759 129.894 1.00 51.26  ? 36  LEU B O   1 
ATOM   37   C CB  . LEU A 1 36  ? 142.751 146.453 127.100 1.00 51.26  ? 36  LEU B CB  1 
ATOM   38   C CG  . LEU A 1 36  ? 144.238 146.766 127.215 1.00 51.26  ? 36  LEU B CG  1 
ATOM   39   C CD1 . LEU A 1 36  ? 145.029 145.918 126.232 1.00 51.26  ? 36  LEU B CD1 1 
ATOM   40   C CD2 . LEU A 1 36  ? 144.473 148.246 126.973 1.00 51.26  ? 36  LEU B CD2 1 
ATOM   41   N N   . LEU A 1 37  ? 141.031 145.658 129.666 1.00 51.78  ? 37  LEU B N   1 
ATOM   42   C CA  . LEU A 1 37  ? 140.783 145.701 131.105 1.00 51.78  ? 37  LEU B CA  1 
ATOM   43   C C   . LEU A 1 37  ? 140.814 144.305 131.709 1.00 51.78  ? 37  LEU B C   1 
ATOM   44   O O   . LEU A 1 37  ? 141.471 144.071 132.731 1.00 51.78  ? 37  LEU B O   1 
ATOM   45   C CB  . LEU A 1 37  ? 139.434 146.364 131.385 1.00 51.78  ? 37  LEU B CB  1 
ATOM   46   C CG  . LEU A 1 37  ? 139.262 147.842 131.046 1.00 51.78  ? 37  LEU B CG  1 
ATOM   47   C CD1 . LEU A 1 37  ? 137.826 148.274 131.258 1.00 51.78  ? 37  LEU B CD1 1 
ATOM   48   C CD2 . LEU A 1 37  ? 140.190 148.669 131.910 1.00 51.78  ? 37  LEU B CD2 1 
ATOM   49   N N   . CYS A 1 38  ? 140.100 143.364 131.090 1.00 55.55  ? 38  CYS B N   1 
ATOM   50   C CA  . CYS A 1 38  ? 140.039 142.017 131.651 1.00 55.55  ? 38  CYS B CA  1 
ATOM   51   C C   . CYS A 1 38  ? 141.387 141.318 131.542 1.00 55.55  ? 38  CYS B C   1 
ATOM   52   O O   . CYS A 1 38  ? 141.781 140.583 132.453 1.00 55.55  ? 38  CYS B O   1 
ATOM   53   C CB  . CYS A 1 38  ? 138.940 141.191 130.979 1.00 55.55  ? 38  CYS B CB  1 
ATOM   54   S SG  . CYS A 1 38  ? 139.254 140.658 129.286 1.00 55.55  ? 38  CYS B SG  1 
ATOM   55   N N   . ALA A 1 39  ? 142.120 141.549 130.447 1.00 54.72  ? 39  ALA B N   1 
ATOM   56   C CA  . ALA A 1 39  ? 143.452 140.966 130.315 1.00 54.72  ? 39  ALA B CA  1 
ATOM   57   C C   . ALA A 1 39  ? 144.409 141.520 131.365 1.00 54.72  ? 39  ALA B C   1 
ATOM   58   O O   . ALA A 1 39  ? 145.191 140.769 131.960 1.00 54.72  ? 39  ALA B O   1 
ATOM   59   C CB  . ALA A 1 39  ? 143.997 141.213 128.909 1.00 54.72  ? 39  ALA B CB  1 
ATOM   60   N N   . TYR A 1 40  ? 144.363 142.832 131.608 1.00 49.94  ? 40  TYR B N   1 
ATOM   61   C CA  . TYR A 1 40  ? 145.226 143.431 132.621 1.00 49.94  ? 40  TYR B CA  1 
ATOM   62   C C   . TYR A 1 40  ? 144.871 142.928 134.014 1.00 49.94  ? 40  TYR B C   1 
ATOM   63   O O   . TYR A 1 40  ? 145.762 142.648 134.821 1.00 49.94  ? 40  TYR B O   1 
ATOM   64   C CB  . TYR A 1 40  ? 145.137 144.958 132.546 1.00 49.94  ? 40  TYR B CB  1 
ATOM   65   C CG  . TYR A 1 40  ? 145.520 145.691 133.817 1.00 49.94  ? 40  TYR B CG  1 
ATOM   66   C CD1 . TYR A 1 40  ? 146.773 145.524 134.396 1.00 49.94  ? 40  TYR B CD1 1 
ATOM   67   C CD2 . TYR A 1 40  ? 144.636 146.574 134.421 1.00 49.94  ? 40  TYR B CD2 1 
ATOM   68   C CE1 . TYR A 1 40  ? 147.123 146.199 135.552 1.00 49.94  ? 40  TYR B CE1 1 
ATOM   69   C CE2 . TYR A 1 40  ? 144.980 147.255 135.572 1.00 49.94  ? 40  TYR B CE2 1 
ATOM   70   C CZ  . TYR A 1 40  ? 146.221 147.064 136.133 1.00 49.94  ? 40  TYR B CZ  1 
ATOM   71   O OH  . TYR A 1 40  ? 146.560 147.743 137.279 1.00 49.94  ? 40  TYR B OH  1 
ATOM   72   N N   . GLY A 1 41  ? 143.577 142.814 134.319 1.00 46.94  ? 41  GLY B N   1 
ATOM   73   C CA  . GLY A 1 41  ? 143.184 142.258 135.605 1.00 46.94  ? 41  GLY B CA  1 
ATOM   74   C C   . GLY A 1 41  ? 143.627 140.818 135.769 1.00 46.94  ? 41  GLY B C   1 
ATOM   75   O O   . GLY A 1 41  ? 144.102 140.420 136.836 1.00 46.94  ? 41  GLY B O   1 
ATOM   76   N N   . PHE A 1 42  ? 143.492 140.022 134.705 1.00 49.10  ? 42  PHE B N   1 
ATOM   77   C CA  . PHE A 1 42  ? 143.941 138.636 134.734 1.00 49.10  ? 42  PHE B CA  1 
ATOM   78   C C   . PHE A 1 42  ? 145.442 138.549 134.974 1.00 49.10  ? 42  PHE B C   1 
ATOM   79   O O   . PHE A 1 42  ? 145.904 137.717 135.762 1.00 49.10  ? 42  PHE B O   1 
ATOM   80   C CB  . PHE A 1 42  ? 143.557 137.953 133.419 1.00 49.10  ? 42  PHE B CB  1 
ATOM   81   C CG  . PHE A 1 42  ? 144.116 136.569 133.257 1.00 49.10  ? 42  PHE B CG  1 
ATOM   82   C CD1 . PHE A 1 42  ? 143.532 135.492 133.896 1.00 49.10  ? 42  PHE B CD1 1 
ATOM   83   C CD2 . PHE A 1 42  ? 145.212 136.343 132.446 1.00 49.10  ? 42  PHE B CD2 1 
ATOM   84   C CE1 . PHE A 1 42  ? 144.040 134.219 133.739 1.00 49.10  ? 42  PHE B CE1 1 
ATOM   85   C CE2 . PHE A 1 42  ? 145.725 135.072 132.288 1.00 49.10  ? 42  PHE B CE2 1 
ATOM   86   C CZ  . PHE A 1 42  ? 145.137 134.010 132.935 1.00 49.10  ? 42  PHE B CZ  1 
ATOM   87   N N   . PHE A 1 43  ? 146.218 139.408 134.309 1.00 50.85  ? 43  PHE B N   1 
ATOM   88   C CA  . PHE A 1 43  ? 147.669 139.357 134.456 1.00 50.85  ? 43  PHE B CA  1 
ATOM   89   C C   . PHE A 1 43  ? 148.111 139.857 135.827 1.00 50.85  ? 43  PHE B C   1 
ATOM   90   O O   . PHE A 1 43  ? 149.007 139.272 136.446 1.00 50.85  ? 43  PHE B O   1 
ATOM   91   C CB  . PHE A 1 43  ? 148.335 140.164 133.341 1.00 50.85  ? 43  PHE B CB  1 
ATOM   92   C CG  . PHE A 1 43  ? 148.440 139.420 132.038 1.00 50.85  ? 43  PHE B CG  1 
ATOM   93   C CD1 . PHE A 1 43  ? 149.026 138.167 131.986 1.00 50.85  ? 43  PHE B CD1 1 
ATOM   94   C CD2 . PHE A 1 43  ? 147.950 139.972 130.867 1.00 50.85  ? 43  PHE B CD2 1 
ATOM   95   C CE1 . PHE A 1 43  ? 149.122 137.479 130.791 1.00 50.85  ? 43  PHE B CE1 1 
ATOM   96   C CE2 . PHE A 1 43  ? 148.042 139.289 129.669 1.00 50.85  ? 43  PHE B CE2 1 
ATOM   97   C CZ  . PHE A 1 43  ? 148.629 138.041 129.631 1.00 50.85  ? 43  PHE B CZ  1 
ATOM   98   N N   . ALA A 1 44  ? 147.496 140.934 136.322 1.00 50.62  ? 44  ALA B N   1 
ATOM   99   C CA  . ALA A 1 44  ? 147.862 141.464 137.632 1.00 50.62  ? 44  ALA B CA  1 
ATOM   100  C C   . ALA A 1 44  ? 147.494 140.492 138.746 1.00 50.62  ? 44  ALA B C   1 
ATOM   101  O O   . ALA A 1 44  ? 148.268 140.302 139.692 1.00 50.62  ? 44  ALA B O   1 
ATOM   102  C CB  . ALA A 1 44  ? 147.191 142.818 137.859 1.00 50.62  ? 44  ALA B CB  1 
ATOM   103  N N   . SER A 1 45  ? 146.317 139.866 138.653 1.00 45.79  ? 45  SER B N   1 
ATOM   104  C CA  . SER A 1 45  ? 145.919 138.894 139.661 1.00 45.79  ? 45  SER B CA  1 
ATOM   105  C C   . SER A 1 45  ? 146.668 137.578 139.521 1.00 45.79  ? 45  SER B C   1 
ATOM   106  O O   . SER A 1 45  ? 146.713 136.801 140.480 1.00 45.79  ? 45  SER B O   1 
ATOM   107  C CB  . SER A 1 45  ? 144.412 138.649 139.588 1.00 45.79  ? 45  SER B CB  1 
ATOM   108  O OG  . SER A 1 45  ? 143.700 139.872 139.525 1.00 45.79  ? 45  SER B OG  1 
ATOM   109  N N   . LEU A 1 46  ? 147.261 137.311 138.359 1.00 49.92  ? 46  LEU B N   1 
ATOM   110  C CA  . LEU A 1 46  ? 148.013 136.076 138.144 1.00 49.92  ? 46  LEU B CA  1 
ATOM   111  C C   . LEU A 1 46  ? 149.339 136.225 138.876 1.00 49.92  ? 46  LEU B C   1 
ATOM   112  O O   . LEU A 1 46  ? 150.334 136.697 138.325 1.00 49.92  ? 46  LEU B O   1 
ATOM   113  C CB  . LEU A 1 46  ? 148.208 135.807 136.655 1.00 49.92  ? 46  LEU B CB  1 
ATOM   114  C CG  . LEU A 1 46  ? 148.716 134.436 136.188 1.00 49.92  ? 46  LEU B CG  1 
ATOM   115  C CD1 . LEU A 1 46  ? 148.195 134.147 134.790 1.00 49.92  ? 46  LEU B CD1 1 
ATOM   116  C CD2 . LEU A 1 46  ? 150.233 134.318 136.214 1.00 49.92  ? 46  LEU B CD2 1 
ATOM   117  N N   . ARG A 1 47  ? 149.348 135.835 140.149 1.00 51.64  ? 47  ARG B N   1 
ATOM   118  C CA  . ARG A 1 47  ? 150.538 135.901 140.994 1.00 51.64  ? 47  ARG B CA  1 
ATOM   119  C C   . ARG A 1 47  ? 150.852 134.492 141.472 1.00 51.64  ? 47  ARG B C   1 
ATOM   120  O O   . ARG A 1 47  ? 150.287 134.025 142.474 1.00 51.64  ? 47  ARG B O   1 
ATOM   121  C CB  . ARG A 1 47  ? 150.332 136.851 142.171 1.00 51.64  ? 47  ARG B CB  1 
ATOM   122  C CG  . ARG A 1 47  ? 149.787 138.214 141.784 1.00 51.64  ? 47  ARG B CG  1 
ATOM   123  C CD  . ARG A 1 47  ? 149.485 139.046 143.018 1.00 51.64  ? 47  ARG B CD  1 
ATOM   124  N NE  . ARG A 1 47  ? 148.568 140.141 142.730 1.00 51.64  ? 47  ARG B NE  1 
ATOM   125  C CZ  . ARG A 1 47  ? 147.766 140.696 143.627 1.00 51.64  ? 47  ARG B CZ  1 
ATOM   126  N NH1 . ARG A 1 47  ? 147.739 140.278 144.882 1.00 51.64  ? 47  ARG B NH1 1 
ATOM   127  N NH2 . ARG A 1 47  ? 146.969 141.695 143.257 1.00 51.64  ? 47  ARG B NH2 1 
ATOM   128  N N   . PRO A 1 48  ? 151.735 133.775 140.782 1.00 50.76  ? 48  PRO B N   1 
ATOM   129  C CA  . PRO A 1 48  ? 152.078 132.409 141.202 1.00 50.76  ? 48  PRO B CA  1 
ATOM   130  C C   . PRO A 1 48  ? 152.751 132.341 142.565 1.00 50.76  ? 48  PRO B C   1 
ATOM   131  O O   . PRO A 1 48  ? 152.762 131.283 143.201 1.00 50.76  ? 48  PRO B O   1 
ATOM   132  C CB  . PRO A 1 48  ? 153.026 131.934 140.093 1.00 50.76  ? 48  PRO B CB  1 
ATOM   133  C CG  . PRO A 1 48  ? 152.695 132.792 138.916 1.00 50.76  ? 48  PRO B CG  1 
ATOM   134  C CD  . PRO A 1 48  ? 152.347 134.127 139.492 1.00 50.76  ? 48  PRO B CD  1 
ATOM   135  N N   . SER A 1 49  ? 153.317 133.456 143.025 1.00 50.26  ? 49  SER B N   1 
ATOM   136  C CA  . SER A 1 49  ? 154.111 133.479 144.247 1.00 50.26  ? 49  SER B CA  1 
ATOM   137  C C   . SER A 1 49  ? 153.275 133.680 145.505 1.00 50.26  ? 49  SER B C   1 
ATOM   138  O O   . SER A 1 49  ? 153.813 133.580 146.613 1.00 50.26  ? 49  SER B O   1 
ATOM   139  C CB  . SER A 1 49  ? 155.179 134.567 144.155 1.00 50.26  ? 49  SER B CB  1 
ATOM   140  O OG  . SER A 1 49  ? 156.048 134.337 143.062 1.00 50.26  ? 49  SER B OG  1 
ATOM   141  N N   . GLU A 1 50  ? 151.984 133.970 145.368 1.00 50.23  ? 50  GLU B N   1 
ATOM   142  C CA  . GLU A 1 50  ? 151.134 134.181 146.535 1.00 50.23  ? 50  GLU B CA  1 
ATOM   143  C C   . GLU A 1 50  ? 151.016 132.934 147.413 1.00 50.23  ? 50  GLU B C   1 
ATOM   144  O O   . GLU A 1 50  ? 151.210 133.042 148.630 1.00 50.23  ? 50  GLU B O   1 
ATOM   145  C CB  . GLU A 1 50  ? 149.745 134.673 146.108 1.00 50.23  ? 50  GLU B CB  1 
ATOM   146  C CG  . GLU A 1 50  ? 148.889 135.173 147.260 1.00 50.23  ? 50  GLU B CG  1 
ATOM   147  C CD  . GLU A 1 50  ? 147.829 136.159 146.818 1.00 50.23  ? 50  GLU B CD  1 
ATOM   148  O OE1 . GLU A 1 50  ? 148.132 137.013 145.958 1.00 50.23  ? 50  GLU B OE1 1 
ATOM   149  O OE2 . GLU A 1 50  ? 146.696 136.086 147.337 1.00 50.23  ? 50  GLU B OE2 1 
ATOM   150  N N   . PRO A 1 51  ? 150.698 131.747 146.874 1.00 50.20  ? 51  PRO B N   1 
ATOM   151  C CA  . PRO A 1 51  ? 150.587 130.568 147.752 1.00 50.20  ? 51  PRO B CA  1 
ATOM   152  C C   . PRO A 1 51  ? 151.886 130.170 148.434 1.00 50.20  ? 51  PRO B C   1 
ATOM   153  O O   . PRO A 1 51  ? 151.841 129.646 149.553 1.00 50.20  ? 51  PRO B O   1 
ATOM   154  C CB  . PRO A 1 51  ? 150.099 129.466 146.801 1.00 50.20  ? 51  PRO B CB  1 
ATOM   155  C CG  . PRO A 1 51  ? 149.484 130.190 145.665 1.00 50.20  ? 51  PRO B CG  1 
ATOM   156  C CD  . PRO A 1 51  ? 150.346 131.391 145.487 1.00 50.20  ? 51  PRO B CD  1 
ATOM   157  N N   . PHE A 1 52  ? 153.038 130.398 147.805 1.00 49.27  ? 52  PHE B N   1 
ATOM   158  C CA  . PHE A 1 52  ? 154.316 129.912 148.308 1.00 49.27  ? 52  PHE B CA  1 
ATOM   159  C C   . PHE A 1 52  ? 155.168 131.015 148.927 1.00 49.27  ? 52  PHE B C   1 
ATOM   160  O O   . PHE A 1 52  ? 156.387 131.030 148.733 1.00 49.27  ? 52  PHE B O   1 
ATOM   161  C CB  . PHE A 1 52  ? 155.090 129.213 147.191 1.00 49.27  ? 52  PHE B CB  1 
ATOM   162  C CG  . PHE A 1 52  ? 154.490 127.907 146.765 1.00 49.27  ? 52  PHE B CG  1 
ATOM   163  C CD1 . PHE A 1 52  ? 154.735 126.751 147.486 1.00 49.27  ? 52  PHE B CD1 1 
ATOM   164  C CD2 . PHE A 1 52  ? 153.679 127.834 145.647 1.00 49.27  ? 52  PHE B CD2 1 
ATOM   165  C CE1 . PHE A 1 52  ? 154.186 125.547 147.100 1.00 49.27  ? 52  PHE B CE1 1 
ATOM   166  C CE2 . PHE A 1 52  ? 153.126 126.632 145.255 1.00 49.27  ? 52  PHE B CE2 1 
ATOM   167  C CZ  . PHE A 1 52  ? 153.380 125.487 145.984 1.00 49.27  ? 52  PHE B CZ  1 
ATOM   168  N N   . LEU A 1 53  ? 154.555 131.945 149.662 1.00 45.75  ? 53  LEU B N   1 
ATOM   169  C CA  . LEU A 1 53  ? 155.326 133.035 150.253 1.00 45.75  ? 53  LEU B CA  1 
ATOM   170  C C   . LEU A 1 53  ? 156.193 132.547 151.408 1.00 45.75  ? 53  LEU B C   1 
ATOM   171  O O   . LEU A 1 53  ? 157.371 132.912 151.503 1.00 45.75  ? 53  LEU B O   1 
ATOM   172  C CB  . LEU A 1 53  ? 154.387 134.152 150.714 1.00 45.75  ? 53  LEU B CB  1 
ATOM   173  C CG  . LEU A 1 53  ? 154.984 135.475 151.210 1.00 45.75  ? 53  LEU B CG  1 
ATOM   174  C CD1 . LEU A 1 53  ? 153.999 136.593 150.983 1.00 45.75  ? 53  LEU B CD1 1 
ATOM   175  C CD2 . LEU A 1 53  ? 155.343 135.427 152.689 1.00 45.75  ? 53  LEU B CD2 1 
ATOM   176  N N   . THR A 1 54  ? 155.628 131.734 152.300 1.00 45.37  ? 54  THR B N   1 
ATOM   177  C CA  . THR A 1 54  ? 156.302 131.399 153.552 1.00 45.37  ? 54  THR B CA  1 
ATOM   178  C C   . THR A 1 54  ? 157.648 130.675 153.411 1.00 45.37  ? 54  THR B C   1 
ATOM   179  O O   . THR A 1 54  ? 158.563 131.002 154.176 1.00 45.37  ? 54  THR B O   1 
ATOM   180  C CB  . THR A 1 54  ? 155.350 130.626 154.486 1.00 45.37  ? 54  THR B CB  1 
ATOM   181  O OG1 . THR A 1 54  ? 155.969 130.450 155.767 1.00 45.37  ? 54  THR B OG1 1 
ATOM   182  C CG2 . THR A 1 54  ? 154.905 129.279 153.930 1.00 45.37  ? 54  THR B CG2 1 
ATOM   183  N N   . PRO A 1 55  ? 157.854 129.713 152.493 1.00 47.94  ? 55  PRO B N   1 
ATOM   184  C CA  . PRO A 1 55  ? 159.175 129.064 152.452 1.00 47.94  ? 55  PRO B CA  1 
ATOM   185  C C   . PRO A 1 55  ? 160.270 129.972 151.924 1.00 47.94  ? 55  PRO B C   1 
ATOM   186  O O   . PRO A 1 55  ? 161.452 129.696 152.164 1.00 47.94  ? 55  PRO B O   1 
ATOM   187  C CB  . PRO A 1 55  ? 158.955 127.858 151.522 1.00 47.94  ? 55  PRO B CB  1 
ATOM   188  C CG  . PRO A 1 55  ? 157.477 127.826 151.234 1.00 47.94  ? 55  PRO B CG  1 
ATOM   189  C CD  . PRO A 1 55  ? 157.048 129.244 151.353 1.00 47.94  ? 55  PRO B CD  1 
ATOM   190  N N   . TYR A 1 56  ? 159.912 131.039 151.205 1.00 49.25  ? 56  TYR B N   1 
ATOM   191  C CA  . TYR A 1 56  ? 160.910 131.974 150.695 1.00 49.25  ? 56  TYR B CA  1 
ATOM   192  C C   . TYR A 1 56  ? 161.604 132.715 151.830 1.00 49.25  ? 56  TYR B C   1 
ATOM   193  O O   . TYR A 1 56  ? 162.827 132.893 151.807 1.00 49.25  ? 56  TYR B O   1 
ATOM   194  C CB  . TYR A 1 56  ? 160.240 132.955 149.732 1.00 49.25  ? 56  TYR B CB  1 
ATOM   195  C CG  . TYR A 1 56  ? 161.166 133.941 149.054 1.00 49.25  ? 56  TYR B CG  1 
ATOM   196  C CD1 . TYR A 1 56  ? 162.137 133.512 148.159 1.00 49.25  ? 56  TYR B CD1 1 
ATOM   197  C CD2 . TYR A 1 56  ? 161.044 135.304 149.282 1.00 49.25  ? 56  TYR B CD2 1 
ATOM   198  C CE1 . TYR A 1 56  ? 162.974 134.413 147.529 1.00 49.25  ? 56  TYR B CE1 1 
ATOM   199  C CE2 . TYR A 1 56  ? 161.876 136.211 148.657 1.00 49.25  ? 56  TYR B CE2 1 
ATOM   200  C CZ  . TYR A 1 56  ? 162.837 135.761 147.783 1.00 49.25  ? 56  TYR B CZ  1 
ATOM   201  O OH  . TYR A 1 56  ? 163.664 136.666 147.162 1.00 49.25  ? 56  TYR B OH  1 
ATOM   202  N N   . LEU A 1 57  ? 160.841 133.147 152.835 1.00 47.02  ? 57  LEU B N   1 
ATOM   203  C CA  . LEU A 1 57  ? 161.421 133.939 153.913 1.00 47.02  ? 57  LEU B CA  1 
ATOM   204  C C   . LEU A 1 57  ? 162.244 133.075 154.862 1.00 47.02  ? 57  LEU B C   1 
ATOM   205  O O   . LEU A 1 57  ? 163.324 133.485 155.302 1.00 47.02  ? 57  LEU B O   1 
ATOM   206  C CB  . LEU A 1 57  ? 160.315 134.674 154.669 1.00 47.02  ? 57  LEU B CB  1 
ATOM   207  C CG  . LEU A 1 57  ? 159.372 135.528 153.816 1.00 47.02  ? 57  LEU B CG  1 
ATOM   208  C CD1 . LEU A 1 57  ? 158.463 136.365 154.697 1.00 47.02  ? 57  LEU B CD1 1 
ATOM   209  C CD2 . LEU A 1 57  ? 160.147 136.413 152.858 1.00 47.02  ? 57  LEU B CD2 1 
ATOM   210  N N   . LEU A 1 58  ? 161.757 131.875 155.183 1.00 51.96  ? 58  LEU B N   1 
ATOM   211  C CA  . LEU A 1 58  ? 162.436 131.027 156.157 1.00 51.96  ? 58  LEU B CA  1 
ATOM   212  C C   . LEU A 1 58  ? 163.731 130.428 155.624 1.00 51.96  ? 58  LEU B C   1 
ATOM   213  O O   . LEU A 1 58  ? 164.637 130.146 156.415 1.00 51.96  ? 58  LEU B O   1 
ATOM   214  C CB  . LEU A 1 58  ? 161.510 129.900 156.617 1.00 51.96  ? 58  LEU B CB  1 
ATOM   215  C CG  . LEU A 1 58  ? 160.566 130.197 157.782 1.00 51.96  ? 58  LEU B CG  1 
ATOM   216  C CD1 . LEU A 1 58  ? 159.366 131.006 157.325 1.00 51.96  ? 58  LEU B CD1 1 
ATOM   217  C CD2 . LEU A 1 58  ? 160.124 128.902 158.441 1.00 51.96  ? 58  LEU B CD2 1 
ATOM   218  N N   . GLY A 1 59  ? 163.842 130.226 154.314 1.00 51.45  ? 59  GLY B N   1 
ATOM   219  C CA  . GLY A 1 59  ? 165.001 129.572 153.758 1.00 51.45  ? 59  GLY B CA  1 
ATOM   220  C C   . GLY A 1 59  ? 166.194 130.495 153.668 1.00 51.45  ? 59  GLY B C   1 
ATOM   221  O O   . GLY A 1 59  ? 166.160 131.666 154.072 1.00 51.45  ? 59  GLY B O   1 
ATOM   222  N N   . PRO A 1 60  ? 167.296 129.954 153.137 1.00 52.99  ? 60  PRO B N   1 
ATOM   223  C CA  . PRO A 1 60  ? 168.498 130.777 152.910 1.00 52.99  ? 60  PRO B CA  1 
ATOM   224  C C   . PRO A 1 60  ? 168.271 132.012 152.044 1.00 52.99  ? 60  PRO B C   1 
ATOM   225  O O   . PRO A 1 60  ? 169.207 132.808 151.892 1.00 52.99  ? 60  PRO B O   1 
ATOM   226  C CB  . PRO A 1 60  ? 169.464 129.805 152.216 1.00 52.99  ? 60  PRO B CB  1 
ATOM   227  C CG  . PRO A 1 60  ? 168.931 128.420 152.488 1.00 52.99  ? 60  PRO B CG  1 
ATOM   228  C CD  . PRO A 1 60  ? 167.621 128.522 153.214 1.00 52.99  ? 60  PRO B CD  1 
ATOM   229  N N   . ASP A 1 61  ? 167.080 132.189 151.465 1.00 54.84  ? 61  ASP B N   1 
ATOM   230  C CA  . ASP A 1 61  ? 166.826 133.344 150.609 1.00 54.84  ? 61  ASP B CA  1 
ATOM   231  C C   . ASP A 1 61  ? 166.950 134.649 151.385 1.00 54.84  ? 61  ASP B C   1 
ATOM   232  O O   . ASP A 1 61  ? 167.498 135.633 150.875 1.00 54.84  ? 61  ASP B O   1 
ATOM   233  C CB  . ASP A 1 61  ? 165.439 133.227 149.981 1.00 54.84  ? 61  ASP B CB  1 
ATOM   234  C CG  . ASP A 1 61  ? 165.190 131.863 149.373 1.00 54.84  ? 61  ASP B CG  1 
ATOM   235  O OD1 . ASP A 1 61  ? 166.139 131.282 148.805 1.00 54.84  ? 61  ASP B OD1 1 
ATOM   236  O OD2 . ASP A 1 61  ? 164.049 131.366 149.471 1.00 54.84  ? 61  ASP B OD2 1 
ATOM   237  N N   . LYS A 1 62  ? 166.444 134.680 152.615 1.00 50.52  ? 62  LYS B N   1 
ATOM   238  C CA  . LYS A 1 62  ? 166.526 135.866 153.455 1.00 50.52  ? 62  LYS B CA  1 
ATOM   239  C C   . LYS A 1 62  ? 167.164 135.618 154.811 1.00 50.52  ? 62  LYS B C   1 
ATOM   240  O O   . LYS A 1 62  ? 167.812 136.525 155.339 1.00 50.52  ? 62  LYS B O   1 
ATOM   241  C CB  . LYS A 1 62  ? 165.131 136.469 153.671 1.00 50.52  ? 62  LYS B CB  1 
ATOM   242  C CG  . LYS A 1 62  ? 164.541 137.115 152.432 1.00 50.52  ? 62  LYS B CG  1 
ATOM   243  C CD  . LYS A 1 62  ? 163.424 138.075 152.795 1.00 50.52  ? 62  LYS B CD  1 
ATOM   244  C CE  . LYS A 1 62  ? 163.079 138.988 151.632 1.00 50.52  ? 62  LYS B CE  1 
ATOM   245  N NZ  . LYS A 1 62  ? 163.570 138.447 150.336 1.00 50.52  ? 62  LYS B NZ  1 
ATOM   246  N N   . ASN A 1 63  ? 167.001 134.424 155.384 1.00 49.64  ? 63  ASN B N   1 
ATOM   247  C CA  . ASN A 1 63  ? 167.543 134.079 156.699 1.00 49.64  ? 63  ASN B CA  1 
ATOM   248  C C   . ASN A 1 63  ? 167.049 135.059 157.766 1.00 49.64  ? 63  ASN B C   1 
ATOM   249  O O   . ASN A 1 63  ? 167.821 135.796 158.384 1.00 49.64  ? 63  ASN B O   1 
ATOM   250  C CB  . ASN A 1 63  ? 169.075 134.017 156.671 1.00 49.64  ? 63  ASN B CB  1 
ATOM   251  C CG  . ASN A 1 63  ? 169.602 133.077 155.606 1.00 49.64  ? 63  ASN B CG  1 
ATOM   252  O OD1 . ASN A 1 63  ? 169.831 131.895 155.861 1.00 49.64  ? 63  ASN B OD1 1 
ATOM   253  N ND2 . ASN A 1 63  ? 169.805 133.601 154.403 1.00 49.64  ? 63  ASN B ND2 1 
ATOM   254  N N   . LEU A 1 64  ? 165.735 135.059 157.964 1.00 55.51  ? 64  LEU B N   1 
ATOM   255  C CA  . LEU A 1 64  ? 165.080 135.922 158.935 1.00 55.51  ? 64  LEU B CA  1 
ATOM   256  C C   . LEU A 1 64  ? 164.495 135.093 160.070 1.00 55.51  ? 64  LEU B C   1 
ATOM   257  O O   . LEU A 1 64  ? 164.088 133.944 159.876 1.00 55.51  ? 64  LEU B O   1 
ATOM   258  C CB  . LEU A 1 64  ? 163.969 136.749 158.281 1.00 55.51  ? 64  LEU B CB  1 
ATOM   259  C CG  . LEU A 1 64  ? 164.408 137.896 157.373 1.00 55.51  ? 64  LEU B CG  1 
ATOM   260  C CD1 . LEU A 1 64  ? 163.197 138.561 156.739 1.00 55.51  ? 64  LEU B CD1 1 
ATOM   261  C CD2 . LEU A 1 64  ? 165.233 138.901 158.158 1.00 55.51  ? 64  LEU B CD2 1 
ATOM   262  N N   . THR A 1 65  ? 164.465 135.682 161.264 1.00 60.13  ? 65  THR B N   1 
ATOM   263  C CA  . THR A 1 65  ? 163.795 135.044 162.389 1.00 60.13  ? 65  THR B CA  1 
ATOM   264  C C   . THR A 1 65  ? 162.289 135.189 162.220 1.00 60.13  ? 65  THR B C   1 
ATOM   265  O O   . THR A 1 65  ? 161.765 136.307 162.169 1.00 60.13  ? 65  THR B O   1 
ATOM   266  C CB  . THR A 1 65  ? 164.250 135.656 163.709 1.00 60.13  ? 65  THR B CB  1 
ATOM   267  O OG1 . THR A 1 65  ? 165.680 135.623 163.788 1.00 60.13  ? 65  THR B OG1 1 
ATOM   268  C CG2 . THR A 1 65  ? 163.667 134.875 164.876 1.00 60.13  ? 65  THR B CG2 1 
ATOM   269  N N   . GLU A 1 66  ? 161.598 134.053 162.133 1.00 65.45  ? 66  GLU B N   1 
ATOM   270  C CA  . GLU A 1 66  ? 160.173 134.064 161.824 1.00 65.45  ? 66  GLU B CA  1 
ATOM   271  C C   . GLU A 1 66  ? 159.339 134.663 162.952 1.00 65.45  ? 66  GLU B C   1 
ATOM   272  O O   . GLU A 1 66  ? 158.294 135.267 162.686 1.00 65.45  ? 66  GLU B O   1 
ATOM   273  C CB  . GLU A 1 66  ? 159.703 132.651 161.470 1.00 65.45  ? 66  GLU B CB  1 
ATOM   274  C CG  . GLU A 1 66  ? 159.846 131.599 162.562 1.00 65.45  ? 66  GLU B CG  1 
ATOM   275  C CD  . GLU A 1 66  ? 161.284 131.186 162.828 1.00 65.45  ? 66  GLU B CD  1 
ATOM   276  O OE1 . GLU A 1 66  ? 162.136 131.383 161.938 1.00 65.45  ? 66  GLU B OE1 1 
ATOM   277  O OE2 . GLU A 1 66  ? 161.558 130.659 163.927 1.00 65.45  ? 66  GLU B OE2 1 
ATOM   278  N N   . ARG A 1 67  ? 159.775 134.518 164.207 1.00 63.42  ? 67  ARG B N   1 
ATOM   279  C CA  . ARG A 1 67  ? 159.142 135.257 165.298 1.00 63.42  ? 67  ARG B CA  1 
ATOM   280  C C   . ARG A 1 67  ? 159.157 136.757 165.030 1.00 63.42  ? 67  ARG B C   1 
ATOM   281  O O   . ARG A 1 67  ? 158.123 137.428 165.129 1.00 63.42  ? 67  ARG B O   1 
ATOM   282  C CB  . ARG A 1 67  ? 159.841 134.955 166.627 1.00 63.42  ? 67  ARG B CB  1 
ATOM   283  C CG  . ARG A 1 67  ? 160.126 133.491 166.946 1.00 63.42  ? 67  ARG B CG  1 
ATOM   284  C CD  . ARG A 1 67  ? 158.952 132.848 167.709 1.00 63.42  ? 67  ARG B CD  1 
ATOM   285  N NE  . ARG A 1 67  ? 157.669 132.827 167.016 1.00 63.42  ? 67  ARG B NE  1 
ATOM   286  C CZ  . ARG A 1 67  ? 157.433 132.210 165.867 1.00 63.42  ? 67  ARG B CZ  1 
ATOM   287  N NH1 . ARG A 1 67  ? 158.342 131.439 165.297 1.00 63.42  ? 67  ARG B NH1 1 
ATOM   288  N NH2 . ARG A 1 67  ? 156.238 132.333 165.299 1.00 63.42  ? 67  ARG B NH2 1 
ATOM   289  N N   . GLU A 1 68  ? 160.326 137.298 164.677 1.00 62.22  ? 68  GLU B N   1 
ATOM   290  C CA  . GLU A 1 68  ? 160.432 138.728 164.404 1.00 62.22  ? 68  GLU B CA  1 
ATOM   291  C C   . GLU A 1 68  ? 159.586 139.120 163.202 1.00 62.22  ? 68  GLU B C   1 
ATOM   292  O O   . GLU A 1 68  ? 158.935 140.173 163.208 1.00 62.22  ? 68  GLU B O   1 
ATOM   293  C CB  . GLU A 1 68  ? 161.892 139.111 164.178 1.00 62.22  ? 68  GLU B CB  1 
ATOM   294  C CG  . GLU A 1 68  ? 162.146 140.603 164.158 1.00 62.22  ? 68  GLU B CG  1 
ATOM   295  C CD  . GLU A 1 68  ? 162.107 141.218 165.543 1.00 62.22  ? 68  GLU B CD  1 
ATOM   296  O OE1 . GLU A 1 68  ? 162.314 140.482 166.530 1.00 62.22  ? 68  GLU B OE1 1 
ATOM   297  O OE2 . GLU A 1 68  ? 161.876 142.440 165.643 1.00 62.22  ? 68  GLU B OE2 1 
ATOM   298  N N   . VAL A 1 69  ? 159.584 138.281 162.164 1.00 60.58  ? 69  VAL B N   1 
ATOM   299  C CA  . VAL A 1 69  ? 158.759 138.533 160.985 1.00 60.58  ? 69  VAL B CA  1 
ATOM   300  C C   . VAL A 1 69  ? 157.297 138.679 161.386 1.00 60.58  ? 69  VAL B C   1 
ATOM   301  O O   . VAL A 1 69  ? 156.689 139.743 161.206 1.00 60.58  ? 69  VAL B O   1 
ATOM   302  C CB  . VAL A 1 69  ? 158.943 137.411 159.949 1.00 60.58  ? 69  VAL B CB  1 
ATOM   303  C CG1 . VAL A 1 69  ? 157.965 137.587 158.801 1.00 60.58  ? 69  VAL B CG1 1 
ATOM   304  C CG2 . VAL A 1 69  ? 160.376 137.389 159.442 1.00 60.58  ? 69  VAL B CG2 1 
ATOM   305  N N   . PHE A 1 70  ? 156.736 137.620 161.982 1.00 63.74  ? 70  PHE B N   1 
ATOM   306  C CA  . PHE A 1 70  ? 155.333 137.624 162.382 1.00 63.74  ? 70  PHE B CA  1 
ATOM   307  C C   . PHE A 1 70  ? 155.013 138.778 163.318 1.00 63.74  ? 70  PHE B C   1 
ATOM   308  O O   . PHE A 1 70  ? 153.938 139.379 163.215 1.00 63.74  ? 70  PHE B O   1 
ATOM   309  C CB  . PHE A 1 70  ? 154.971 136.301 163.060 1.00 63.74  ? 70  PHE B CB  1 
ATOM   310  C CG  . PHE A 1 70  ? 154.998 135.116 162.140 1.00 63.74  ? 70  PHE B CG  1 
ATOM   311  C CD1 . PHE A 1 70  ? 154.442 135.193 160.876 1.00 63.74  ? 70  PHE B CD1 1 
ATOM   312  C CD2 . PHE A 1 70  ? 155.570 133.920 162.544 1.00 63.74  ? 70  PHE B CD2 1 
ATOM   313  C CE1 . PHE A 1 70  ? 154.464 134.101 160.029 1.00 63.74  ? 70  PHE B CE1 1 
ATOM   314  C CE2 . PHE A 1 70  ? 155.596 132.827 161.701 1.00 63.74  ? 70  PHE B CE2 1 
ATOM   315  C CZ  . PHE A 1 70  ? 155.044 132.918 160.443 1.00 63.74  ? 70  PHE B CZ  1 
ATOM   316  N N   . ASN A 1 71  ? 155.931 139.113 164.226 1.00 61.03  ? 71  ASN B N   1 
ATOM   317  C CA  . ASN A 1 71  ? 155.624 140.112 165.239 1.00 61.03  ? 71  ASN B CA  1 
ATOM   318  C C   . ASN A 1 71  ? 155.669 141.532 164.686 1.00 61.03  ? 71  ASN B C   1 
ATOM   319  O O   . ASN A 1 71  ? 154.866 142.378 165.095 1.00 61.03  ? 71  ASN B O   1 
ATOM   320  C CB  . ASN A 1 71  ? 156.586 139.965 166.419 1.00 61.03  ? 71  ASN B CB  1 
ATOM   321  C CG  . ASN A 1 71  ? 156.152 138.884 167.394 1.00 61.03  ? 71  ASN B CG  1 
ATOM   322  O OD1 . ASN A 1 71  ? 156.872 137.911 167.621 1.00 61.03  ? 71  ASN B OD1 1 
ATOM   323  N ND2 . ASN A 1 71  ? 154.970 139.051 167.978 1.00 61.03  ? 71  ASN B ND2 1 
ATOM   324  N N   . GLU A 1 72  ? 156.579 141.820 163.756 1.00 59.59  ? 72  GLU B N   1 
ATOM   325  C CA  . GLU A 1 72  ? 156.818 143.213 163.404 1.00 59.59  ? 72  GLU B CA  1 
ATOM   326  C C   . GLU A 1 72  ? 156.494 143.572 161.962 1.00 59.59  ? 72  GLU B C   1 
ATOM   327  O O   . GLU A 1 72  ? 156.003 144.678 161.717 1.00 59.59  ? 72  GLU B O   1 
ATOM   328  C CB  . GLU A 1 72  ? 158.276 143.585 163.709 1.00 59.59  ? 72  GLU B CB  1 
ATOM   329  C CG  . GLU A 1 72  ? 158.537 143.812 165.193 1.00 59.59  ? 72  GLU B CG  1 
ATOM   330  C CD  . GLU A 1 72  ? 159.757 144.671 165.459 1.00 59.59  ? 72  GLU B CD  1 
ATOM   331  O OE1 . GLU A 1 72  ? 160.459 145.027 164.491 1.00 59.59  ? 72  GLU B OE1 1 
ATOM   332  O OE2 . GLU A 1 72  ? 160.015 144.992 166.638 1.00 59.59  ? 72  GLU B OE2 1 
ATOM   333  N N   . ILE A 1 73  ? 156.758 142.693 160.992 1.00 57.98  ? 73  ILE B N   1 
ATOM   334  C CA  . ILE A 1 73  ? 156.646 143.078 159.586 1.00 57.98  ? 73  ILE B CA  1 
ATOM   335  C C   . ILE A 1 73  ? 155.206 143.410 159.215 1.00 57.98  ? 73  ILE B C   1 
ATOM   336  O O   . ILE A 1 73  ? 154.938 144.399 158.526 1.00 57.98  ? 73  ILE B O   1 
ATOM   337  C CB  . ILE A 1 73  ? 157.193 141.973 158.666 1.00 57.98  ? 73  ILE B CB  1 
ATOM   338  C CG1 . ILE A 1 73  ? 158.598 141.552 159.104 1.00 57.98  ? 73  ILE B CG1 1 
ATOM   339  C CG2 . ILE A 1 73  ? 157.164 142.429 157.215 1.00 57.98  ? 73  ILE B CG2 1 
ATOM   340  C CD1 . ILE A 1 73  ? 159.594 142.685 159.169 1.00 57.98  ? 73  ILE B CD1 1 
ATOM   341  N N   . TYR A 1 74  ? 154.274 142.582 159.672 1.00 58.57  ? 74  TYR B N   1 
ATOM   342  C CA  . TYR A 1 74  ? 152.896 142.682 159.202 1.00 58.57  ? 74  TYR B CA  1 
ATOM   343  C C   . TYR A 1 74  ? 152.071 143.802 159.839 1.00 58.57  ? 74  TYR B C   1 
ATOM   344  O O   . TYR A 1 74  ? 151.236 144.382 159.124 1.00 58.57  ? 74  TYR B O   1 
ATOM   345  C CB  . TYR A 1 74  ? 152.228 141.315 159.384 1.00 58.57  ? 74  TYR B CB  1 
ATOM   346  C CG  . TYR A 1 74  ? 153.024 140.193 158.748 1.00 58.57  ? 74  TYR B CG  1 
ATOM   347  C CD1 . TYR A 1 74  ? 153.746 139.299 159.526 1.00 58.57  ? 74  TYR B CD1 1 
ATOM   348  C CD2 . TYR A 1 74  ? 153.049 140.027 157.369 1.00 58.57  ? 74  TYR B CD2 1 
ATOM   349  C CE1 . TYR A 1 74  ? 154.473 138.278 158.950 1.00 58.57  ? 74  TYR B CE1 1 
ATOM   350  C CE2 . TYR A 1 74  ? 153.772 139.005 156.786 1.00 58.57  ? 74  TYR B CE2 1 
ATOM   351  C CZ  . TYR A 1 74  ? 154.481 138.135 157.582 1.00 58.57  ? 74  TYR B CZ  1 
ATOM   352  O OH  . TYR A 1 74  ? 155.204 137.116 157.009 1.00 58.57  ? 74  TYR B OH  1 
ATOM   353  N N   . PRO A 1 75  ? 152.204 144.139 161.151 1.00 57.02  ? 75  PRO B N   1 
ATOM   354  C CA  . PRO A 1 75  ? 151.365 145.214 161.713 1.00 57.02  ? 75  PRO B CA  1 
ATOM   355  C C   . PRO A 1 75  ? 151.471 146.563 161.011 1.00 57.02  ? 75  PRO B C   1 
ATOM   356  O O   . PRO A 1 75  ? 150.461 147.261 160.857 1.00 57.02  ? 75  PRO B O   1 
ATOM   357  C CB  . PRO A 1 75  ? 151.864 145.320 163.159 1.00 57.02  ? 75  PRO B CB  1 
ATOM   358  C CG  . PRO A 1 75  ? 152.323 143.966 163.486 1.00 57.02  ? 75  PRO B CG  1 
ATOM   359  C CD  . PRO A 1 75  ? 152.883 143.382 162.222 1.00 57.02  ? 75  PRO B CD  1 
ATOM   360  N N   . VAL A 1 76  ? 152.679 146.952 160.592 1.00 56.78  ? 76  VAL B N   1 
ATOM   361  C CA  . VAL A 1 76  ? 152.840 148.238 159.923 1.00 56.78  ? 76  VAL B CA  1 
ATOM   362  C C   . VAL A 1 76  ? 152.188 148.242 158.550 1.00 56.78  ? 76  VAL B C   1 
ATOM   363  O O   . VAL A 1 76  ? 151.750 149.296 158.086 1.00 56.78  ? 76  VAL B O   1 
ATOM   364  C CB  . VAL A 1 76  ? 154.325 148.631 159.827 1.00 56.78  ? 76  VAL B CB  1 
ATOM   365  C CG1 . VAL A 1 76  ? 154.834 149.091 161.185 1.00 56.78  ? 76  VAL B CG1 1 
ATOM   366  C CG2 . VAL A 1 76  ? 155.154 147.470 159.308 1.00 56.78  ? 76  VAL B CG2 1 
ATOM   367  N N   . TRP A 1 77  ? 152.112 147.087 157.887 1.00 54.14  ? 77  TRP B N   1 
ATOM   368  C CA  . TRP A 1 77  ? 151.289 146.966 156.688 1.00 54.14  ? 77  TRP B CA  1 
ATOM   369  C C   . TRP A 1 77  ? 149.847 147.360 156.976 1.00 54.14  ? 77  TRP B C   1 
ATOM   370  O O   . TRP A 1 77  ? 149.249 148.154 156.241 1.00 54.14  ? 77  TRP B O   1 
ATOM   371  C CB  . TRP A 1 77  ? 151.362 145.531 156.162 1.00 54.14  ? 77  TRP B CB  1 
ATOM   372  C CG  . TRP A 1 77  ? 150.385 145.188 155.071 1.00 54.14  ? 77  TRP B CG  1 
ATOM   373  C CD1 . TRP A 1 77  ? 149.837 146.034 154.152 1.00 54.14  ? 77  TRP B CD1 1 
ATOM   374  C CD2 . TRP A 1 77  ? 149.822 143.897 154.810 1.00 54.14  ? 77  TRP B CD2 1 
ATOM   375  N NE1 . TRP A 1 77  ? 148.977 145.349 153.330 1.00 54.14  ? 77  TRP B NE1 1 
ATOM   376  C CE2 . TRP A 1 77  ? 148.951 144.034 153.714 1.00 54.14  ? 77  TRP B CE2 1 
ATOM   377  C CE3 . TRP A 1 77  ? 149.976 142.636 155.395 1.00 54.14  ? 77  TRP B CE3 1 
ATOM   378  C CZ2 . TRP A 1 77  ? 148.233 142.961 153.193 1.00 54.14  ? 77  TRP B CZ2 1 
ATOM   379  C CZ3 . TRP A 1 77  ? 149.263 141.574 154.876 1.00 54.14  ? 77  TRP B CZ3 1 
ATOM   380  C CH2 . TRP A 1 77  ? 148.407 141.741 153.783 1.00 54.14  ? 77  TRP B CH2 1 
ATOM   381  N N   . THR A 1 78  ? 149.274 146.813 158.048 1.00 56.58  ? 78  THR B N   1 
ATOM   382  C CA  . THR A 1 78  ? 147.895 147.122 158.402 1.00 56.58  ? 78  THR B CA  1 
ATOM   383  C C   . THR A 1 78  ? 147.732 148.602 158.729 1.00 56.58  ? 78  THR B C   1 
ATOM   384  O O   . THR A 1 78  ? 146.770 149.250 158.296 1.00 56.58  ? 78  THR B O   1 
ATOM   385  C CB  . THR A 1 78  ? 147.467 146.253 159.583 1.00 56.58  ? 78  THR B CB  1 
ATOM   386  O OG1 . THR A 1 78  ? 148.040 146.774 160.788 1.00 56.58  ? 78  THR B OG1 1 
ATOM   387  C CG2 . THR A 1 78  ? 147.956 144.830 159.387 1.00 56.58  ? 78  THR B CG2 1 
ATOM   388  N N   . TYR A 1 79  ? 148.675 149.155 159.496 1.00 60.14  ? 79  TYR B N   1 
ATOM   389  C CA  . TYR A 1 79  ? 148.595 150.566 159.866 1.00 60.14  ? 79  TYR B CA  1 
ATOM   390  C C   . TYR A 1 79  ? 148.685 151.467 158.641 1.00 60.14  ? 79  TYR B C   1 
ATOM   391  O O   . TYR A 1 79  ? 147.927 152.436 158.513 1.00 60.14  ? 79  TYR B O   1 
ATOM   392  C CB  . TYR A 1 79  ? 149.704 150.931 160.856 1.00 60.14  ? 79  TYR B CB  1 
ATOM   393  C CG  . TYR A 1 79  ? 149.836 150.014 162.049 1.00 60.14  ? 79  TYR B CG  1 
ATOM   394  C CD1 . TYR A 1 79  ? 148.725 149.415 162.622 1.00 60.14  ? 79  TYR B CD1 1 
ATOM   395  C CD2 . TYR A 1 79  ? 151.078 149.760 162.610 1.00 60.14  ? 79  TYR B CD2 1 
ATOM   396  C CE1 . TYR A 1 79  ? 148.850 148.581 163.713 1.00 60.14  ? 79  TYR B CE1 1 
ATOM   397  C CE2 . TYR A 1 79  ? 151.214 148.928 163.697 1.00 60.14  ? 79  TYR B CE2 1 
ATOM   398  C CZ  . TYR A 1 79  ? 150.098 148.342 164.247 1.00 60.14  ? 79  TYR B CZ  1 
ATOM   399  O OH  . TYR A 1 79  ? 150.235 147.512 165.336 1.00 60.14  ? 79  TYR B OH  1 
ATOM   400  N N   . SER A 1 80  ? 149.618 151.168 157.734 1.00 62.78  ? 80  SER B N   1 
ATOM   401  C CA  . SER A 1 80  ? 149.765 151.965 156.524 1.00 62.78  ? 80  SER B CA  1 
ATOM   402  C C   . SER A 1 80  ? 148.531 151.858 155.648 1.00 62.78  ? 80  SER B C   1 
ATOM   403  O O   . SER A 1 80  ? 148.087 152.855 155.071 1.00 62.78  ? 80  SER B O   1 
ATOM   404  C CB  . SER A 1 80  ? 151.004 151.526 155.748 1.00 62.78  ? 80  SER B CB  1 
ATOM   405  O OG  . SER A 1 80  ? 150.910 151.923 154.391 1.00 62.78  ? 80  SER B OG  1 
ATOM   406  N N   . TYR A 1 81  ? 147.963 150.657 155.531 1.00 59.17  ? 81  TYR B N   1 
ATOM   407  C CA  . TYR A 1 81  ? 146.755 150.498 154.734 1.00 59.17  ? 81  TYR B CA  1 
ATOM   408  C C   . TYR A 1 81  ? 145.609 151.309 155.326 1.00 59.17  ? 81  TYR B C   1 
ATOM   409  O O   . TYR A 1 81  ? 144.877 151.984 154.594 1.00 59.17  ? 81  TYR B O   1 
ATOM   410  C CB  . TYR A 1 81  ? 146.395 149.017 154.628 1.00 59.17  ? 81  TYR B CB  1 
ATOM   411  C CG  . TYR A 1 81  ? 145.177 148.729 153.782 1.00 59.17  ? 81  TYR B CG  1 
ATOM   412  C CD1 . TYR A 1 81  ? 145.241 148.783 152.399 1.00 59.17  ? 81  TYR B CD1 1 
ATOM   413  C CD2 . TYR A 1 81  ? 143.972 148.384 154.365 1.00 59.17  ? 81  TYR B CD2 1 
ATOM   414  C CE1 . TYR A 1 81  ? 144.130 148.515 151.622 1.00 59.17  ? 81  TYR B CE1 1 
ATOM   415  C CE2 . TYR A 1 81  ? 142.858 148.112 153.598 1.00 59.17  ? 81  TYR B CE2 1 
ATOM   416  C CZ  . TYR A 1 81  ? 142.941 148.180 152.228 1.00 59.17  ? 81  TYR B CZ  1 
ATOM   417  O OH  . TYR A 1 81  ? 141.832 147.911 151.461 1.00 59.17  ? 81  TYR B OH  1 
ATOM   418  N N   . LEU A 1 82  ? 145.473 151.291 156.655 1.00 62.10  ? 82  LEU B N   1 
ATOM   419  C CA  . LEU A 1 82  ? 144.461 152.112 157.318 1.00 62.10  ? 82  LEU B CA  1 
ATOM   420  C C   . LEU A 1 82  ? 144.667 153.595 157.038 1.00 62.10  ? 82  LEU B C   1 
ATOM   421  O O   . LEU A 1 82  ? 143.731 154.301 156.645 1.00 62.10  ? 82  LEU B O   1 
ATOM   422  C CB  . LEU A 1 82  ? 144.484 151.857 158.824 1.00 62.10  ? 82  LEU B CB  1 
ATOM   423  C CG  . LEU A 1 82  ? 143.424 152.629 159.611 1.00 62.10  ? 82  LEU B CG  1 
ATOM   424  C CD1 . LEU A 1 82  ? 142.024 152.229 159.196 1.00 62.10  ? 82  LEU B CD1 1 
ATOM   425  C CD2 . LEU A 1 82  ? 143.622 152.445 161.107 1.00 62.10  ? 82  LEU B CD2 1 
ATOM   426  N N   . VAL A 1 83  ? 145.891 154.089 157.238 1.00 61.58  ? 83  VAL B N   1 
ATOM   427  C CA  . VAL A 1 83  ? 146.128 155.524 157.137 1.00 61.58  ? 83  VAL B CA  1 
ATOM   428  C C   . VAL A 1 83  ? 146.131 155.993 155.689 1.00 61.58  ? 83  VAL B C   1 
ATOM   429  O O   . VAL A 1 83  ? 145.920 157.183 155.426 1.00 61.58  ? 83  VAL B O   1 
ATOM   430  C CB  . VAL A 1 83  ? 147.446 155.897 157.847 1.00 61.58  ? 83  VAL B CB  1 
ATOM   431  C CG1 . VAL A 1 83  ? 148.649 155.450 157.030 1.00 61.58  ? 83  VAL B CG1 1 
ATOM   432  C CG2 . VAL A 1 83  ? 147.504 157.391 158.142 1.00 61.58  ? 83  VAL B CG2 1 
ATOM   433  N N   . LEU A 1 84  ? 146.331 155.085 154.734 1.00 64.17  ? 84  LEU B N   1 
ATOM   434  C CA  . LEU A 1 84  ? 146.501 155.453 153.340 1.00 64.17  ? 84  LEU B CA  1 
ATOM   435  C C   . LEU A 1 84  ? 145.292 155.131 152.473 1.00 64.17  ? 84  LEU B C   1 
ATOM   436  O O   . LEU A 1 84  ? 145.204 155.651 151.356 1.00 64.17  ? 84  LEU B O   1 
ATOM   437  C CB  . LEU A 1 84  ? 147.762 154.761 152.787 1.00 64.17  ? 84  LEU B CB  1 
ATOM   438  C CG  . LEU A 1 84  ? 148.367 155.037 151.408 1.00 64.17  ? 84  LEU B CG  1 
ATOM   439  C CD1 . LEU A 1 84  ? 149.858 154.782 151.469 1.00 64.17  ? 84  LEU B CD1 1 
ATOM   440  C CD2 . LEU A 1 84  ? 147.761 154.136 150.350 1.00 64.17  ? 84  LEU B CD2 1 
ATOM   441  N N   . LEU A 1 85  ? 144.345 154.324 152.961 1.00 61.83  ? 85  LEU B N   1 
ATOM   442  C CA  . LEU A 1 85  ? 143.163 154.010 152.165 1.00 61.83  ? 85  LEU B CA  1 
ATOM   443  C C   . LEU A 1 85  ? 142.361 155.268 151.855 1.00 61.83  ? 85  LEU B C   1 
ATOM   444  O O   . LEU A 1 85  ? 141.992 155.512 150.701 1.00 61.83  ? 85  LEU B O   1 
ATOM   445  C CB  . LEU A 1 85  ? 142.310 152.973 152.903 1.00 61.83  ? 85  LEU B CB  1 
ATOM   446  C CG  . LEU A 1 85  ? 141.094 152.321 152.233 1.00 61.83  ? 85  LEU B CG  1 
ATOM   447  C CD1 . LEU A 1 85  ? 140.855 150.953 152.843 1.00 61.83  ? 85  LEU B CD1 1 
ATOM   448  C CD2 . LEU A 1 85  ? 139.835 153.166 152.373 1.00 61.83  ? 85  LEU B CD2 1 
ATOM   449  N N   . PHE A 1 86  ? 142.099 156.089 152.872 1.00 60.13  ? 86  PHE B N   1 
ATOM   450  C CA  . PHE A 1 86  ? 141.318 157.310 152.674 1.00 60.13  ? 86  PHE B CA  1 
ATOM   451  C C   . PHE A 1 86  ? 141.959 158.289 151.692 1.00 60.13  ? 86  PHE B C   1 
ATOM   452  O O   . PHE A 1 86  ? 141.246 158.778 150.795 1.00 60.13  ? 86  PHE B O   1 
ATOM   453  C CB  . PHE A 1 86  ? 141.056 157.961 154.038 1.00 60.13  ? 86  PHE B CB  1 
ATOM   454  C CG  . PHE A 1 86  ? 140.276 159.242 153.966 1.00 60.13  ? 86  PHE B CG  1 
ATOM   455  C CD1 . PHE A 1 86  ? 138.903 159.226 153.796 1.00 60.13  ? 86  PHE B CD1 1 
ATOM   456  C CD2 . PHE A 1 86  ? 140.919 160.465 154.079 1.00 60.13  ? 86  PHE B CD2 1 
ATOM   457  C CE1 . PHE A 1 86  ? 138.184 160.408 153.737 1.00 60.13  ? 86  PHE B CE1 1 
ATOM   458  C CE2 . PHE A 1 86  ? 140.208 161.649 154.018 1.00 60.13  ? 86  PHE B CE2 1 
ATOM   459  C CZ  . PHE A 1 86  ? 138.838 161.621 153.846 1.00 60.13  ? 86  PHE B CZ  1 
ATOM   460  N N   . PRO A 1 87  ? 143.257 158.625 151.788 1.00 63.82  ? 87  PRO B N   1 
ATOM   461  C CA  . PRO A 1 87  ? 143.822 159.570 150.805 1.00 63.82  ? 87  PRO B CA  1 
ATOM   462  C C   . PRO A 1 87  ? 143.738 159.087 149.367 1.00 63.82  ? 87  PRO B C   1 
ATOM   463  O O   . PRO A 1 87  ? 143.328 159.856 148.491 1.00 63.82  ? 87  PRO B O   1 
ATOM   464  C CB  . PRO A 1 87  ? 145.275 159.727 151.275 1.00 63.82  ? 87  PRO B CB  1 
ATOM   465  C CG  . PRO A 1 87  ? 145.232 159.431 152.717 1.00 63.82  ? 87  PRO B CG  1 
ATOM   466  C CD  . PRO A 1 87  ? 144.233 158.330 152.854 1.00 63.82  ? 87  PRO B CD  1 
ATOM   467  N N   . VAL A 1 88  ? 144.112 157.835 149.090 1.00 59.07  ? 88  VAL B N   1 
ATOM   468  C CA  . VAL A 1 88  ? 144.039 157.359 147.712 1.00 59.07  ? 88  VAL B CA  1 
ATOM   469  C C   . VAL A 1 88  ? 142.591 157.206 147.267 1.00 59.07  ? 88  VAL B C   1 
ATOM   470  O O   . VAL A 1 88  ? 142.273 157.420 146.091 1.00 59.07  ? 88  VAL B O   1 
ATOM   471  C CB  . VAL A 1 88  ? 144.827 156.047 147.535 1.00 59.07  ? 88  VAL B CB  1 
ATOM   472  C CG1 . VAL A 1 88  ? 146.299 156.277 147.823 1.00 59.07  ? 88  VAL B CG1 1 
ATOM   473  C CG2 . VAL A 1 88  ? 144.263 154.945 148.416 1.00 59.07  ? 88  VAL B CG2 1 
ATOM   474  N N   . PHE A 1 89  ? 141.691 156.842 148.184 1.00 60.39  ? 89  PHE B N   1 
ATOM   475  C CA  . PHE A 1 89  ? 140.284 156.714 147.821 1.00 60.39  ? 89  PHE B CA  1 
ATOM   476  C C   . PHE A 1 89  ? 139.709 158.060 147.400 1.00 60.39  ? 89  PHE B C   1 
ATOM   477  O O   . PHE A 1 89  ? 138.903 158.133 146.466 1.00 60.39  ? 89  PHE B O   1 
ATOM   478  C CB  . PHE A 1 89  ? 139.492 156.122 148.987 1.00 60.39  ? 89  PHE B CB  1 
ATOM   479  C CG  . PHE A 1 89  ? 138.038 155.910 148.691 1.00 60.39  ? 89  PHE B CG  1 
ATOM   480  C CD1 . PHE A 1 89  ? 137.631 154.849 147.899 1.00 60.39  ? 89  PHE B CD1 1 
ATOM   481  C CD2 . PHE A 1 89  ? 137.078 156.759 149.213 1.00 60.39  ? 89  PHE B CD2 1 
ATOM   482  C CE1 . PHE A 1 89  ? 136.294 154.644 147.626 1.00 60.39  ? 89  PHE B CE1 1 
ATOM   483  C CE2 . PHE A 1 89  ? 135.737 156.560 148.943 1.00 60.39  ? 89  PHE B CE2 1 
ATOM   484  C CZ  . PHE A 1 89  ? 135.345 155.501 148.149 1.00 60.39  ? 89  PHE B CZ  1 
ATOM   485  N N   . LEU A 1 90  ? 140.112 159.138 148.077 1.00 59.21  ? 90  LEU B N   1 
ATOM   486  C CA  . LEU A 1 90  ? 139.691 160.466 147.643 1.00 59.21  ? 90  LEU B CA  1 
ATOM   487  C C   . LEU A 1 90  ? 140.439 160.930 146.397 1.00 59.21  ? 90  LEU B C   1 
ATOM   488  O O   . LEU A 1 90  ? 139.878 161.672 145.580 1.00 59.21  ? 90  LEU B O   1 
ATOM   489  C CB  . LEU A 1 90  ? 139.869 161.474 148.779 1.00 59.21  ? 90  LEU B CB  1 
ATOM   490  C CG  . LEU A 1 90  ? 138.584 161.842 149.527 1.00 59.21  ? 90  LEU B CG  1 
ATOM   491  C CD1 . LEU A 1 90  ? 138.002 160.636 150.245 1.00 59.21  ? 90  LEU B CD1 1 
ATOM   492  C CD2 . LEU A 1 90  ? 138.831 162.979 150.504 1.00 59.21  ? 90  LEU B CD2 1 
ATOM   493  N N   . ALA A 1 91  ? 141.693 160.505 146.227 1.00 58.59  ? 91  ALA B N   1 
ATOM   494  C CA  . ALA A 1 91  ? 142.449 160.882 145.039 1.00 58.59  ? 91  ALA B CA  1 
ATOM   495  C C   . ALA A 1 91  ? 141.888 160.230 143.782 1.00 58.59  ? 91  ALA B C   1 
ATOM   496  O O   . ALA A 1 91  ? 142.050 160.770 142.682 1.00 58.59  ? 91  ALA B O   1 
ATOM   497  C CB  . ALA A 1 91  ? 143.923 160.519 145.214 1.00 58.59  ? 91  ALA B CB  1 
ATOM   498  N N   . THR A 1 92  ? 141.246 159.067 143.923 1.00 57.08  ? 92  THR B N   1 
ATOM   499  C CA  . THR A 1 92  ? 140.569 158.449 142.785 1.00 57.08  ? 92  THR B CA  1 
ATOM   500  C C   . THR A 1 92  ? 139.535 159.396 142.193 1.00 57.08  ? 92  THR B C   1 
ATOM   501  O O   . THR A 1 92  ? 139.488 159.606 140.976 1.00 57.08  ? 92  THR B O   1 
ATOM   502  C CB  . THR A 1 92  ? 139.899 157.141 143.207 1.00 57.08  ? 92  THR B CB  1 
ATOM   503  O OG1 . THR A 1 92  ? 139.039 157.382 144.327 1.00 57.08  ? 92  THR B OG1 1 
ATOM   504  C CG2 . THR A 1 92  ? 140.933 156.105 143.582 1.00 57.08  ? 92  THR B CG2 1 
ATOM   505  N N   . ASP A 1 93  ? 138.694 159.983 143.047 1.00 52.42  ? 93  ASP B N   1 
ATOM   506  C CA  . ASP A 1 93  ? 137.747 160.983 142.575 1.00 52.42  ? 93  ASP B CA  1 
ATOM   507  C C   . ASP A 1 93  ? 138.453 162.265 142.158 1.00 52.42  ? 93  ASP B C   1 
ATOM   508  O O   . ASP A 1 93  ? 138.000 162.944 141.229 1.00 52.42  ? 93  ASP B O   1 
ATOM   509  C CB  . ASP A 1 93  ? 136.704 161.275 143.653 1.00 52.42  ? 93  ASP B CB  1 
ATOM   510  C CG  . ASP A 1 93  ? 135.446 161.905 143.091 1.00 52.42  ? 93  ASP B CG  1 
ATOM   511  O OD1 . ASP A 1 93  ? 135.463 163.122 142.808 1.00 52.42  ? 93  ASP B OD1 1 
ATOM   512  O OD2 . ASP A 1 93  ? 134.440 161.183 142.926 1.00 52.42  ? 93  ASP B OD2 1 
ATOM   513  N N   . TYR A 1 94  ? 139.554 162.616 142.832 1.00 56.75  ? 94  TYR B N   1 
ATOM   514  C CA  . TYR A 1 94  ? 140.286 163.824 142.461 1.00 56.75  ? 94  TYR B CA  1 
ATOM   515  C C   . TYR A 1 94  ? 140.846 163.718 141.046 1.00 56.75  ? 94  TYR B C   1 
ATOM   516  O O   . TYR A 1 94  ? 140.765 164.675 140.267 1.00 56.75  ? 94  TYR B O   1 
ATOM   517  C CB  . TYR A 1 94  ? 141.408 164.095 143.466 1.00 56.75  ? 94  TYR B CB  1 
ATOM   518  C CG  . TYR A 1 94  ? 141.830 165.551 143.545 1.00 56.75  ? 94  TYR B CG  1 
ATOM   519  C CD1 . TYR A 1 94  ? 141.567 166.311 144.677 1.00 56.75  ? 94  TYR B CD1 1 
ATOM   520  C CD2 . TYR A 1 94  ? 142.485 166.167 142.486 1.00 56.75  ? 94  TYR B CD2 1 
ATOM   521  C CE1 . TYR A 1 94  ? 141.948 167.638 144.750 1.00 56.75  ? 94  TYR B CE1 1 
ATOM   522  C CE2 . TYR A 1 94  ? 142.865 167.492 142.551 1.00 56.75  ? 94  TYR B CE2 1 
ATOM   523  C CZ  . TYR A 1 94  ? 142.596 168.222 143.683 1.00 56.75  ? 94  TYR B CZ  1 
ATOM   524  O OH  . TYR A 1 94  ? 142.978 169.541 143.743 1.00 56.75  ? 94  TYR B OH  1 
ATOM   525  N N   . LEU A 1 95  ? 141.404 162.563 140.692 1.00 60.30  ? 95  LEU B N   1 
ATOM   526  C CA  . LEU A 1 95  ? 142.033 162.363 139.394 1.00 60.30  ? 95  LEU B CA  1 
ATOM   527  C C   . LEU A 1 95  ? 141.143 161.606 138.413 1.00 60.30  ? 95  LEU B C   1 
ATOM   528  O O   . LEU A 1 95  ? 141.608 161.246 137.325 1.00 60.30  ? 95  LEU B O   1 
ATOM   529  C CB  . LEU A 1 95  ? 143.368 161.637 139.569 1.00 60.30  ? 95  LEU B CB  1 
ATOM   530  C CG  . LEU A 1 95  ? 144.524 162.489 140.095 1.00 60.30  ? 95  LEU B CG  1 
ATOM   531  C CD1 . LEU A 1 95  ? 145.664 161.606 140.563 1.00 60.30  ? 95  LEU B CD1 1 
ATOM   532  C CD2 . LEU A 1 95  ? 145.004 163.463 139.032 1.00 60.30  ? 95  LEU B CD2 1 
ATOM   533  N N   . ARG A 1 96  ? 139.882 161.355 138.776 1.00 59.16  ? 96  ARG B N   1 
ATOM   534  C CA  . ARG A 1 96  ? 138.897 160.730 137.889 1.00 59.16  ? 96  ARG B CA  1 
ATOM   535  C C   . ARG A 1 96  ? 139.346 159.344 137.419 1.00 59.16  ? 96  ARG B C   1 
ATOM   536  O O   . ARG A 1 96  ? 139.190 158.987 136.250 1.00 59.16  ? 96  ARG B O   1 
ATOM   537  C CB  . ARG A 1 96  ? 138.586 161.632 136.691 1.00 59.16  ? 96  ARG B CB  1 
ATOM   538  C CG  . ARG A 1 96  ? 138.053 163.019 137.046 1.00 59.16  ? 96  ARG B CG  1 
ATOM   539  C CD  . ARG A 1 96  ? 136.685 162.973 137.714 1.00 59.16  ? 96  ARG B CD  1 
ATOM   540  N NE  . ARG A 1 96  ? 136.289 164.284 138.217 1.00 59.16  ? 96  ARG B NE  1 
ATOM   541  C CZ  . ARG A 1 96  ? 135.276 164.498 139.046 1.00 59.16  ? 96  ARG B CZ  1 
ATOM   542  N NH1 . ARG A 1 96  ? 134.525 163.505 139.490 1.00 59.16  ? 96  ARG B NH1 1 
ATOM   543  N NH2 . ARG A 1 96  ? 135.008 165.741 139.435 1.00 59.16  ? 96  ARG B NH2 1 
ATOM   544  N N   . TYR A 1 97  ? 139.924 158.565 138.334 1.00 60.40  ? 97  TYR B N   1 
ATOM   545  C CA  . TYR A 1 97  ? 140.265 157.150 138.179 1.00 60.40  ? 97  TYR B CA  1 
ATOM   546  C C   . TYR A 1 97  ? 141.315 156.857 137.113 1.00 60.40  ? 97  TYR B C   1 
ATOM   547  O O   . TYR A 1 97  ? 141.594 155.679 136.863 1.00 60.40  ? 97  TYR B O   1 
ATOM   548  C CB  . TYR A 1 97  ? 139.043 156.277 137.856 1.00 60.40  ? 97  TYR B CB  1 
ATOM   549  C CG  . TYR A 1 97  ? 137.956 156.269 138.903 1.00 60.40  ? 97  TYR B CG  1 
ATOM   550  C CD1 . TYR A 1 97  ? 138.002 155.382 139.969 1.00 60.40  ? 97  TYR B CD1 1 
ATOM   551  C CD2 . TYR A 1 97  ? 136.867 157.125 138.810 1.00 60.40  ? 97  TYR B CD2 1 
ATOM   552  C CE1 . TYR A 1 97  ? 137.008 155.361 140.923 1.00 60.40  ? 97  TYR B CE1 1 
ATOM   553  C CE2 . TYR A 1 97  ? 135.865 157.109 139.761 1.00 60.40  ? 97  TYR B CE2 1 
ATOM   554  C CZ  . TYR A 1 97  ? 135.941 156.224 140.814 1.00 60.40  ? 97  TYR B CZ  1 
ATOM   555  O OH  . TYR A 1 97  ? 134.948 156.201 141.766 1.00 60.40  ? 97  TYR B OH  1 
ATOM   556  N N   . LYS A 1 98  ? 141.898 157.860 136.467 1.00 54.27  ? 98  LYS B N   1 
ATOM   557  C CA  . LYS A 1 98  ? 142.823 157.545 135.381 1.00 54.27  ? 98  LYS B CA  1 
ATOM   558  C C   . LYS A 1 98  ? 144.189 157.075 135.884 1.00 54.27  ? 98  LYS B C   1 
ATOM   559  O O   . LYS A 1 98  ? 144.627 155.984 135.499 1.00 54.27  ? 98  LYS B O   1 
ATOM   560  C CB  . LYS A 1 98  ? 142.986 158.741 134.436 1.00 54.27  ? 98  LYS B CB  1 
ATOM   561  C CG  . LYS A 1 98  ? 143.660 158.388 133.119 1.00 54.27  ? 98  LYS B CG  1 
ATOM   562  C CD  . LYS A 1 98  ? 143.600 159.545 132.137 1.00 54.27  ? 98  LYS B CD  1 
ATOM   563  C CE  . LYS A 1 98  ? 144.141 159.138 130.778 1.00 54.27  ? 98  LYS B CE  1 
ATOM   564  N NZ  . LYS A 1 98  ? 143.332 158.056 130.156 1.00 54.27  ? 98  LYS B NZ  1 
ATOM   565  N N   . PRO A 1 99  ? 144.898 157.833 136.731 1.00 53.48  ? 99  PRO B N   1 
ATOM   566  C CA  . PRO A 1 99  ? 146.270 157.434 137.073 1.00 53.48  ? 99  PRO B CA  1 
ATOM   567  C C   . PRO A 1 99  ? 146.360 156.362 138.145 1.00 53.48  ? 99  PRO B C   1 
ATOM   568  O O   . PRO A 1 99  ? 147.473 155.920 138.453 1.00 53.48  ? 99  PRO B O   1 
ATOM   569  C CB  . PRO A 1 99  ? 146.903 158.749 137.569 1.00 53.48  ? 99  PRO B CB  1 
ATOM   570  C CG  . PRO A 1 99  ? 145.835 159.819 137.390 1.00 53.48  ? 99  PRO B CG  1 
ATOM   571  C CD  . PRO A 1 99  ? 144.550 159.083 137.425 1.00 53.48  ? 99  PRO B CD  1 
ATOM   572  N N   . VAL A 1 100 ? 145.236 155.937 138.725 1.00 54.49  ? 100 VAL B N   1 
ATOM   573  C CA  . VAL A 1 100 ? 145.289 155.008 139.848 1.00 54.49  ? 100 VAL B CA  1 
ATOM   574  C C   . VAL A 1 100 ? 145.801 153.639 139.415 1.00 54.49  ? 100 VAL B C   1 
ATOM   575  O O   . VAL A 1 100 ? 146.511 152.967 140.173 1.00 54.49  ? 100 VAL B O   1 
ATOM   576  C CB  . VAL A 1 100 ? 143.909 154.926 140.522 1.00 54.49  ? 100 VAL B CB  1 
ATOM   577  C CG1 . VAL A 1 100 ? 143.541 156.278 141.103 1.00 54.49  ? 100 VAL B CG1 1 
ATOM   578  C CG2 . VAL A 1 100 ? 142.854 154.484 139.527 1.00 54.49  ? 100 VAL B CG2 1 
ATOM   579  N N   . VAL A 1 101 ? 145.461 153.199 138.202 1.00 53.03  ? 101 VAL B N   1 
ATOM   580  C CA  . VAL A 1 101 ? 145.998 151.938 137.704 1.00 53.03  ? 101 VAL B CA  1 
ATOM   581  C C   . VAL A 1 101 ? 147.503 152.049 137.485 1.00 53.03  ? 101 VAL B C   1 
ATOM   582  O O   . VAL A 1 101 ? 148.250 151.089 137.709 1.00 53.03  ? 101 VAL B O   1 
ATOM   583  C CB  . VAL A 1 101 ? 145.254 151.513 136.425 1.00 53.03  ? 101 VAL B CB  1 
ATOM   584  C CG1 . VAL A 1 101 ? 143.856 151.034 136.769 1.00 53.03  ? 101 VAL B CG1 1 
ATOM   585  C CG2 . VAL A 1 101 ? 145.179 152.667 135.444 1.00 53.03  ? 101 VAL B CG2 1 
ATOM   586  N N   . LEU A 1 102 ? 147.971 153.220 137.050 1.00 49.30  ? 102 LEU B N   1 
ATOM   587  C CA  . LEU A 1 102 ? 149.406 153.454 136.935 1.00 49.30  ? 102 LEU B CA  1 
ATOM   588  C C   . LEU A 1 102 ? 150.079 153.389 138.301 1.00 49.30  ? 102 LEU B C   1 
ATOM   589  O O   . LEU A 1 102 ? 151.176 152.831 138.441 1.00 49.30  ? 102 LEU B O   1 
ATOM   590  C CB  . LEU A 1 102 ? 149.659 154.810 136.275 1.00 49.30  ? 102 LEU B CB  1 
ATOM   591  C CG  . LEU A 1 102 ? 149.748 154.904 134.748 1.00 49.30  ? 102 LEU B CG  1 
ATOM   592  C CD1 . LEU A 1 102 ? 150.985 154.196 134.232 1.00 49.30  ? 102 LEU B CD1 1 
ATOM   593  C CD2 . LEU A 1 102 ? 148.498 154.359 134.070 1.00 49.30  ? 102 LEU B CD2 1 
ATOM   594  N N   . LEU A 1 103 ? 149.434 153.966 139.318 1.00 48.33  ? 103 LEU B N   1 
ATOM   595  C CA  . LEU A 1 103 ? 149.941 153.860 140.683 1.00 48.33  ? 103 LEU B CA  1 
ATOM   596  C C   . LEU A 1 103 ? 150.030 152.406 141.123 1.00 48.33  ? 103 LEU B C   1 
ATOM   597  O O   . LEU A 1 103 ? 151.031 151.988 141.716 1.00 48.33  ? 103 LEU B O   1 
ATOM   598  C CB  . LEU A 1 103 ? 149.053 154.650 141.648 1.00 48.33  ? 103 LEU B CB  1 
ATOM   599  C CG  . LEU A 1 103 ? 149.349 156.120 141.971 1.00 48.33  ? 103 LEU B CG  1 
ATOM   600  C CD1 . LEU A 1 103 ? 149.024 157.060 140.831 1.00 48.33  ? 103 LEU B CD1 1 
ATOM   601  C CD2 . LEU A 1 103 ? 148.589 156.537 143.222 1.00 48.33  ? 103 LEU B CD2 1 
ATOM   602  N N   . GLN A 1 104 ? 148.994 151.620 140.827 1.00 54.12  ? 104 GLN B N   1 
ATOM   603  C CA  . GLN A 1 104 ? 148.983 150.207 141.196 1.00 54.12  ? 104 GLN B CA  1 
ATOM   604  C C   . GLN A 1 104 ? 150.108 149.446 140.501 1.00 54.12  ? 104 GLN B C   1 
ATOM   605  O O   . GLN A 1 104 ? 150.803 148.636 141.128 1.00 54.12  ? 104 GLN B O   1 
ATOM   606  C CB  . GLN A 1 104 ? 147.615 149.612 140.855 1.00 54.12  ? 104 GLN B CB  1 
ATOM   607  C CG  . GLN A 1 104 ? 147.342 148.191 141.340 1.00 54.12  ? 104 GLN B CG  1 
ATOM   608  C CD  . GLN A 1 104 ? 147.744 147.132 140.339 1.00 54.12  ? 104 GLN B CD  1 
ATOM   609  O OE1 . GLN A 1 104 ? 147.781 147.382 139.135 1.00 54.12  ? 104 GLN B OE1 1 
ATOM   610  N NE2 . GLN A 1 104 ? 147.997 145.926 140.826 1.00 54.12  ? 104 GLN B NE2 1 
ATOM   611  N N   . GLY A 1 105 ? 150.314 149.710 139.210 1.00 48.83  ? 105 GLY B N   1 
ATOM   612  C CA  . GLY A 1 105 ? 151.373 149.025 138.485 1.00 48.83  ? 105 GLY B CA  1 
ATOM   613  C C   . GLY A 1 105 ? 152.758 149.382 138.992 1.00 48.83  ? 105 GLY B C   1 
ATOM   614  O O   . GLY A 1 105 ? 153.606 148.507 139.189 1.00 48.83  ? 105 GLY B O   1 
ATOM   615  N N   . LEU A 1 106 ? 153.006 150.677 139.214 1.00 49.96  ? 106 LEU B N   1 
ATOM   616  C CA  . LEU A 1 106 ? 154.305 151.088 139.737 1.00 49.96  ? 106 LEU B CA  1 
ATOM   617  C C   . LEU A 1 106 ? 154.533 150.527 141.134 1.00 49.96  ? 106 LEU B C   1 
ATOM   618  O O   . LEU A 1 106 ? 155.660 150.150 141.486 1.00 49.96  ? 106 LEU B O   1 
ATOM   619  C CB  . LEU A 1 106 ? 154.421 152.612 139.745 1.00 49.96  ? 106 LEU B CB  1 
ATOM   620  C CG  . LEU A 1 106 ? 155.771 153.143 140.244 1.00 49.96  ? 106 LEU B CG  1 
ATOM   621  C CD1 . LEU A 1 106 ? 156.894 152.743 139.296 1.00 49.96  ? 106 LEU B CD1 1 
ATOM   622  C CD2 . LEU A 1 106 ? 155.744 154.651 140.436 1.00 49.96  ? 106 LEU B CD2 1 
ATOM   623  N N   . SER A 1 107 ? 153.475 150.464 141.946 1.00 53.78  ? 107 SER B N   1 
ATOM   624  C CA  . SER A 1 107 ? 153.602 149.877 143.273 1.00 53.78  ? 107 SER B CA  1 
ATOM   625  C C   . SER A 1 107 ? 153.943 148.397 143.192 1.00 53.78  ? 107 SER B C   1 
ATOM   626  O O   . SER A 1 107 ? 154.754 147.908 143.979 1.00 53.78  ? 107 SER B O   1 
ATOM   627  C CB  . SER A 1 107 ? 152.320 150.081 144.071 1.00 53.78  ? 107 SER B CB  1 
ATOM   628  O OG  . SER A 1 107 ? 152.498 149.603 145.389 1.00 53.78  ? 107 SER B OG  1 
ATOM   629  N N   . LEU A 1 108 ? 153.332 147.667 142.257 1.00 51.75  ? 108 LEU B N   1 
ATOM   630  C CA  . LEU A 1 108 ? 153.712 146.269 142.065 1.00 51.75  ? 108 LEU B CA  1 
ATOM   631  C C   . LEU A 1 108 ? 155.170 146.140 141.646 1.00 51.75  ? 108 LEU B C   1 
ATOM   632  O O   . LEU A 1 108 ? 155.892 145.270 142.151 1.00 51.75  ? 108 LEU B O   1 
ATOM   633  C CB  . LEU A 1 108 ? 152.795 145.597 141.042 1.00 51.75  ? 108 LEU B CB  1 
ATOM   634  C CG  . LEU A 1 108 ? 151.572 144.845 141.575 1.00 51.75  ? 108 LEU B CG  1 
ATOM   635  C CD1 . LEU A 1 108 ? 152.016 143.612 142.343 1.00 51.75  ? 108 LEU B CD1 1 
ATOM   636  C CD2 . LEU A 1 108 ? 150.729 145.725 142.471 1.00 51.75  ? 108 LEU B CD2 1 
ATOM   637  N N   . ILE A 1 109 ? 155.626 147.000 140.732 1.00 51.13  ? 109 ILE B N   1 
ATOM   638  C CA  . ILE A 1 109 ? 157.017 146.932 140.285 1.00 51.13  ? 109 ILE B CA  1 
ATOM   639  C C   . ILE A 1 109 ? 157.970 147.150 141.455 1.00 51.13  ? 109 ILE B C   1 
ATOM   640  O O   . ILE A 1 109 ? 158.901 146.362 141.678 1.00 51.13  ? 109 ILE B O   1 
ATOM   641  C CB  . ILE A 1 109 ? 157.278 147.944 139.155 1.00 51.13  ? 109 ILE B CB  1 
ATOM   642  C CG1 . ILE A 1 109 ? 156.367 147.667 137.960 1.00 51.13  ? 109 ILE B CG1 1 
ATOM   643  C CG2 . ILE A 1 109 ? 158.737 147.907 138.739 1.00 51.13  ? 109 ILE B CG2 1 
ATOM   644  C CD1 . ILE A 1 109 ? 156.576 146.298 137.344 1.00 51.13  ? 109 ILE B CD1 1 
ATOM   645  N N   . VAL A 1 110 ? 157.745 148.216 142.226 1.00 53.00  ? 110 VAL B N   1 
ATOM   646  C CA  . VAL A 1 110 ? 158.654 148.510 143.330 1.00 53.00  ? 110 VAL B CA  1 
ATOM   647  C C   . VAL A 1 110 ? 158.524 147.464 144.434 1.00 53.00  ? 110 VAL B C   1 
ATOM   648  O O   . VAL A 1 110 ? 159.520 147.105 145.076 1.00 53.00  ? 110 VAL B O   1 
ATOM   649  C CB  . VAL A 1 110 ? 158.432 149.941 143.855 1.00 53.00  ? 110 VAL B CB  1 
ATOM   650  C CG1 . VAL A 1 110 ? 157.052 150.100 144.464 1.00 53.00  ? 110 VAL B CG1 1 
ATOM   651  C CG2 . VAL A 1 110 ? 159.513 150.309 144.855 1.00 53.00  ? 110 VAL B CG2 1 
ATOM   652  N N   . THR A 1 111 ? 157.317 146.935 144.654 1.00 51.53  ? 111 THR B N   1 
ATOM   653  C CA  . THR A 1 111 ? 157.110 145.904 145.663 1.00 51.53  ? 111 THR B CA  1 
ATOM   654  C C   . THR A 1 111 ? 157.894 144.650 145.322 1.00 51.53  ? 111 THR B C   1 
ATOM   655  O O   . THR A 1 111 ? 158.532 144.047 146.187 1.00 51.53  ? 111 THR B O   1 
ATOM   656  C CB  . THR A 1 111 ? 155.622 145.576 145.780 1.00 51.53  ? 111 THR B CB  1 
ATOM   657  O OG1 . THR A 1 111 ? 154.881 146.773 146.043 1.00 51.53  ? 111 THR B OG1 1 
ATOM   658  C CG2 . THR A 1 111 ? 155.386 144.574 146.900 1.00 51.53  ? 111 THR B CG2 1 
ATOM   659  N N   . TRP A 1 112 ? 157.867 144.244 144.053 1.00 52.28  ? 112 TRP B N   1 
ATOM   660  C CA  . TRP A 1 112 ? 158.553 143.013 143.687 1.00 52.28  ? 112 TRP B CA  1 
ATOM   661  C C   . TRP A 1 112 ? 160.061 143.219 143.624 1.00 52.28  ? 112 TRP B C   1 
ATOM   662  O O   . TRP A 1 112 ? 160.829 142.318 143.981 1.00 52.28  ? 112 TRP B O   1 
ATOM   663  C CB  . TRP A 1 112 ? 157.992 142.473 142.377 1.00 52.28  ? 112 TRP B CB  1 
ATOM   664  C CG  . TRP A 1 112 ? 156.693 141.781 142.622 1.00 52.28  ? 112 TRP B CG  1 
ATOM   665  C CD1 . TRP A 1 112 ? 155.447 142.330 142.559 1.00 52.28  ? 112 TRP B CD1 1 
ATOM   666  C CD2 . TRP A 1 112 ? 156.512 140.426 143.045 1.00 52.28  ? 112 TRP B CD2 1 
ATOM   667  N NE1 . TRP A 1 112 ? 154.498 141.392 142.883 1.00 52.28  ? 112 TRP B NE1 1 
ATOM   668  C CE2 . TRP A 1 112 ? 155.128 140.214 143.188 1.00 52.28  ? 112 TRP B CE2 1 
ATOM   669  C CE3 . TRP A 1 112 ? 157.386 139.366 143.300 1.00 52.28  ? 112 TRP B CE3 1 
ATOM   670  C CZ2 . TRP A 1 112 ? 154.599 138.990 143.573 1.00 52.28  ? 112 TRP B CZ2 1 
ATOM   671  C CZ3 . TRP A 1 112 ? 156.859 138.154 143.682 1.00 52.28  ? 112 TRP B CZ3 1 
ATOM   672  C CH2 . TRP A 1 112 ? 155.478 137.975 143.815 1.00 52.28  ? 112 TRP B CH2 1 
ATOM   673  N N   . PHE A 1 113 ? 160.506 144.414 143.222 1.00 51.45  ? 113 PHE B N   1 
ATOM   674  C CA  . PHE A 1 113 ? 161.931 144.718 143.320 1.00 51.45  ? 113 PHE B CA  1 
ATOM   675  C C   . PHE A 1 113 ? 162.405 144.645 144.768 1.00 51.45  ? 113 PHE B C   1 
ATOM   676  O O   . PHE A 1 113 ? 163.449 144.045 145.058 1.00 51.45  ? 113 PHE B O   1 
ATOM   677  C CB  . PHE A 1 113 ? 162.213 146.097 142.719 1.00 51.45  ? 113 PHE B CB  1 
ATOM   678  C CG  . PHE A 1 113 ? 163.649 146.546 142.847 1.00 51.45  ? 113 PHE B CG  1 
ATOM   679  C CD1 . PHE A 1 113 ? 164.695 145.636 142.789 1.00 51.45  ? 113 PHE B CD1 1 
ATOM   680  C CD2 . PHE A 1 113 ? 163.947 147.887 143.031 1.00 51.45  ? 113 PHE B CD2 1 
ATOM   681  C CE1 . PHE A 1 113 ? 166.005 146.056 142.916 1.00 51.45  ? 113 PHE B CE1 1 
ATOM   682  C CE2 . PHE A 1 113 ? 165.255 148.313 143.154 1.00 51.45  ? 113 PHE B CE2 1 
ATOM   683  C CZ  . PHE A 1 113 ? 166.285 147.396 143.096 1.00 51.45  ? 113 PHE B CZ  1 
ATOM   684  N N   . MET A 1 114 ? 161.640 145.225 145.695 1.00 54.28  ? 114 MET B N   1 
ATOM   685  C CA  . MET A 1 114 ? 162.038 145.198 147.098 1.00 54.28  ? 114 MET B CA  1 
ATOM   686  C C   . MET A 1 114 ? 161.940 143.791 147.676 1.00 54.28  ? 114 MET B C   1 
ATOM   687  O O   . MET A 1 114 ? 162.749 143.407 148.526 1.00 54.28  ? 114 MET B O   1 
ATOM   688  C CB  . MET A 1 114 ? 161.181 146.173 147.901 1.00 54.28  ? 114 MET B CB  1 
ATOM   689  C CG  . MET A 1 114 ? 161.774 146.546 149.243 1.00 54.28  ? 114 MET B CG  1 
ATOM   690  S SD  . MET A 1 114 ? 163.257 147.549 149.058 1.00 54.28  ? 114 MET B SD  1 
ATOM   691  C CE  . MET A 1 114 ? 163.986 147.366 150.682 1.00 54.28  ? 114 MET B CE  1 
ATOM   692  N N   . LEU A 1 115 ? 160.951 143.012 147.235 1.00 46.63  ? 115 LEU B N   1 
ATOM   693  C CA  . LEU A 1 115 ? 160.831 141.635 147.694 1.00 46.63  ? 115 LEU B CA  1 
ATOM   694  C C   . LEU A 1 115 ? 162.007 140.798 147.220 1.00 46.63  ? 115 LEU B C   1 
ATOM   695  O O   . LEU A 1 115 ? 162.453 139.894 147.935 1.00 46.63  ? 115 LEU B O   1 
ATOM   696  C CB  . LEU A 1 115 ? 159.508 141.041 147.213 1.00 46.63  ? 115 LEU B CB  1 
ATOM   697  C CG  . LEU A 1 115 ? 159.048 139.721 147.831 1.00 46.63  ? 115 LEU B CG  1 
ATOM   698  C CD1 . LEU A 1 115 ? 157.543 139.735 148.007 1.00 46.63  ? 115 LEU B CD1 1 
ATOM   699  C CD2 . LEU A 1 115 ? 159.465 138.536 146.974 1.00 46.63  ? 115 LEU B CD2 1 
ATOM   700  N N   . LEU A 1 116 ? 162.518 141.084 146.023 1.00 48.89  ? 116 LEU B N   1 
ATOM   701  C CA  . LEU A 1 116 ? 163.716 140.404 145.551 1.00 48.89  ? 116 LEU B CA  1 
ATOM   702  C C   . LEU A 1 116 ? 164.975 140.930 146.235 1.00 48.89  ? 116 LEU B C   1 
ATOM   703  O O   . LEU A 1 116 ? 165.975 140.208 146.322 1.00 48.89  ? 116 LEU B O   1 
ATOM   704  C CB  . LEU A 1 116 ? 163.823 140.547 144.034 1.00 48.89  ? 116 LEU B CB  1 
ATOM   705  C CG  . LEU A 1 116 ? 162.710 139.844 143.253 1.00 48.89  ? 116 LEU B CG  1 
ATOM   706  C CD1 . LEU A 1 116 ? 162.637 140.365 141.829 1.00 48.89  ? 116 LEU B CD1 1 
ATOM   707  C CD2 . LEU A 1 116 ? 162.914 138.338 143.267 1.00 48.89  ? 116 LEU B CD2 1 
ATOM   708  N N   . TYR A 1 117 ? 164.950 142.172 146.726 1.00 49.28  ? 117 TYR B N   1 
ATOM   709  C CA  . TYR A 1 117 ? 166.131 142.784 147.344 1.00 49.28  ? 117 TYR B CA  1 
ATOM   710  C C   . TYR A 1 117 ? 165.718 143.546 148.601 1.00 49.28  ? 117 TYR B C   1 
ATOM   711  O O   . TYR A 1 117 ? 165.249 144.685 148.512 1.00 49.28  ? 117 TYR B O   1 
ATOM   712  C CB  . TYR A 1 117 ? 166.841 143.704 146.358 1.00 49.28  ? 117 TYR B CB  1 
ATOM   713  N N   . ALA A 1 118 ? 165.906 142.920 149.766 1.00 52.00  ? 118 ALA B N   1 
ATOM   714  C CA  . ALA A 1 118 ? 165.674 143.566 151.056 1.00 52.00  ? 118 ALA B CA  1 
ATOM   715  C C   . ALA A 1 118 ? 166.277 142.746 152.189 1.00 52.00  ? 118 ALA B C   1 
ATOM   716  O O   . ALA A 1 118 ? 166.055 141.534 152.267 1.00 52.00  ? 118 ALA B O   1 
ATOM   717  C CB  . ALA A 1 118 ? 164.181 143.771 151.311 1.00 52.00  ? 118 ALA B CB  1 
ATOM   718  N N   . GLN A 1 119 ? 167.033 143.394 153.075 1.00 56.32  ? 119 GLN B N   1 
ATOM   719  C CA  . GLN A 1 119 ? 167.655 142.726 154.209 1.00 56.32  ? 119 GLN B CA  1 
ATOM   720  C C   . GLN A 1 119 ? 167.420 143.524 155.484 1.00 56.32  ? 119 GLN B C   1 
ATOM   721  O O   . GLN A 1 119 ? 167.351 144.756 155.463 1.00 56.32  ? 119 GLN B O   1 
ATOM   722  C CB  . GLN A 1 119 ? 169.170 142.530 154.001 1.00 56.32  ? 119 GLN B CB  1 
ATOM   723  C CG  . GLN A 1 119 ? 169.558 141.971 152.645 1.00 56.32  ? 119 GLN B CG  1 
ATOM   724  C CD  . GLN A 1 119 ? 168.921 140.626 152.374 1.00 56.32  ? 119 GLN B CD  1 
ATOM   725  O OE1 . GLN A 1 119 ? 168.820 139.784 153.265 1.00 56.32  ? 119 GLN B OE1 1 
ATOM   726  N NE2 . GLN A 1 119 ? 168.478 140.420 151.141 1.00 56.32  ? 119 GLN B NE2 1 
ATOM   727  N N   . GLY A 1 120 ? 167.308 142.807 156.599 1.00 50.87  ? 120 GLY B N   1 
ATOM   728  C CA  . GLY A 1 120 ? 167.169 143.440 157.895 1.00 50.87  ? 120 GLY B CA  1 
ATOM   729  C C   . GLY A 1 120 ? 165.756 143.417 158.437 1.00 50.87  ? 120 GLY B C   1 
ATOM   730  O O   . GLY A 1 120 ? 165.070 142.395 158.365 1.00 50.87  ? 120 GLY B O   1 
ATOM   731  N N   . LEU A 1 121 ? 165.327 144.533 159.020 1.00 51.74  ? 121 LEU B N   1 
ATOM   732  C CA  . LEU A 1 121 ? 163.960 144.706 159.494 1.00 51.74  ? 121 LEU B CA  1 
ATOM   733  C C   . LEU A 1 121 ? 163.271 145.892 158.840 1.00 51.74  ? 121 LEU B C   1 
ATOM   734  O O   . LEU A 1 121 ? 162.137 145.763 158.361 1.00 51.74  ? 121 LEU B O   1 
ATOM   735  C CB  . LEU A 1 121 ? 163.948 144.869 161.023 1.00 51.74  ? 121 LEU B CB  1 
ATOM   736  C CG  . LEU A 1 121 ? 164.659 143.796 161.853 1.00 51.74  ? 121 LEU B CG  1 
ATOM   737  C CD1 . LEU A 1 121 ? 166.104 144.177 162.148 1.00 51.74  ? 121 LEU B CD1 1 
ATOM   738  C CD2 . LEU A 1 121 ? 163.905 143.561 163.147 1.00 51.74  ? 121 LEU B CD2 1 
ATOM   739  N N   . LEU A 1 122 ? 163.935 147.051 158.799 1.00 47.83  ? 122 LEU B N   1 
ATOM   740  C CA  . LEU A 1 122 ? 163.326 148.240 158.216 1.00 47.83  ? 122 LEU B CA  1 
ATOM   741  C C   . LEU A 1 122 ? 163.132 148.094 156.713 1.00 47.83  ? 122 LEU B C   1 
ATOM   742  O O   . LEU A 1 122 ? 162.137 148.587 156.166 1.00 47.83  ? 122 LEU B O   1 
ATOM   743  C CB  . LEU A 1 122 ? 164.180 149.467 158.534 1.00 47.83  ? 122 LEU B CB  1 
ATOM   744  C CG  . LEU A 1 122 ? 163.541 150.841 158.327 1.00 47.83  ? 122 LEU B CG  1 
ATOM   745  C CD1 . LEU A 1 122 ? 162.314 150.997 159.207 1.00 47.83  ? 122 LEU B CD1 1 
ATOM   746  C CD2 . LEU A 1 122 ? 164.541 151.951 158.606 1.00 47.83  ? 122 LEU B CD2 1 
ATOM   747  N N   . ALA A 1 123 ? 164.063 147.421 156.032 1.00 50.45  ? 123 ALA B N   1 
ATOM   748  C CA  . ALA A 1 123 ? 163.921 147.208 154.595 1.00 50.45  ? 123 ALA B CA  1 
ATOM   749  C C   . ALA A 1 123 ? 162.675 146.392 154.290 1.00 50.45  ? 123 ALA B C   1 
ATOM   750  O O   . ALA A 1 123 ? 161.929 146.698 153.355 1.00 50.45  ? 123 ALA B O   1 
ATOM   751  C CB  . ALA A 1 123 ? 165.165 146.518 154.036 1.00 50.45  ? 123 ALA B CB  1 
ATOM   752  N N   . ILE A 1 124 ? 162.419 145.357 155.088 1.00 52.66  ? 124 ILE B N   1 
ATOM   753  C CA  . ILE A 1 124 ? 161.231 144.546 154.862 1.00 52.66  ? 124 ILE B CA  1 
ATOM   754  C C   . ILE A 1 124 ? 159.981 145.280 155.347 1.00 52.66  ? 124 ILE B C   1 
ATOM   755  O O   . ILE A 1 124 ? 158.876 145.053 154.833 1.00 52.66  ? 124 ILE B O   1 
ATOM   756  C CB  . ILE A 1 124 ? 161.412 143.157 155.508 1.00 52.66  ? 124 ILE B CB  1 
ATOM   757  C CG1 . ILE A 1 124 ? 162.579 142.410 154.850 1.00 52.66  ? 124 ILE B CG1 1 
ATOM   758  C CG2 . ILE A 1 124 ? 160.179 142.303 155.331 1.00 52.66  ? 124 ILE B CG2 1 
ATOM   759  C CD1 . ILE A 1 124 ? 163.940 142.649 155.463 1.00 52.66  ? 124 ILE B CD1 1 
ATOM   760  N N   . GLN A 1 125 ? 160.128 146.204 156.300 1.00 54.36  ? 125 GLN B N   1 
ATOM   761  C CA  . GLN A 1 125 ? 159.006 147.073 156.643 1.00 54.36  ? 125 GLN B CA  1 
ATOM   762  C C   . GLN A 1 125 ? 158.593 147.924 155.446 1.00 54.36  ? 125 GLN B C   1 
ATOM   763  O O   . GLN A 1 125 ? 157.403 148.048 155.138 1.00 54.36  ? 125 GLN B O   1 
ATOM   764  C CB  . GLN A 1 125 ? 159.359 147.957 157.840 1.00 54.36  ? 125 GLN B CB  1 
ATOM   765  C CG  . GLN A 1 125 ? 159.321 147.240 159.180 1.00 54.36  ? 125 GLN B CG  1 
ATOM   766  C CD  . GLN A 1 125 ? 159.453 148.192 160.352 1.00 54.36  ? 125 GLN B CD  1 
ATOM   767  O OE1 . GLN A 1 125 ? 159.623 149.396 160.171 1.00 54.36  ? 125 GLN B OE1 1 
ATOM   768  N NE2 . GLN A 1 125 ? 159.372 147.656 161.564 1.00 54.36  ? 125 GLN B NE2 1 
ATOM   769  N N   . PHE A 1 126 ? 159.572 148.506 154.748 1.00 52.43  ? 126 PHE B N   1 
ATOM   770  C CA  . PHE A 1 126 ? 159.263 149.220 153.509 1.00 52.43  ? 126 PHE B CA  1 
ATOM   771  C C   . PHE A 1 126 ? 158.720 148.273 152.444 1.00 52.43  ? 126 PHE B C   1 
ATOM   772  O O   . PHE A 1 126 ? 157.842 148.650 151.657 1.00 52.43  ? 126 PHE B O   1 
ATOM   773  C CB  . PHE A 1 126 ? 160.491 149.959 152.979 1.00 52.43  ? 126 PHE B CB  1 
ATOM   774  C CG  . PHE A 1 126 ? 160.938 151.103 153.840 1.00 52.43  ? 126 PHE B CG  1 
ATOM   775  C CD1 . PHE A 1 126 ? 160.145 152.232 153.973 1.00 52.43  ? 126 PHE B CD1 1 
ATOM   776  C CD2 . PHE A 1 126 ? 162.168 151.081 154.470 1.00 52.43  ? 126 PHE B CD2 1 
ATOM   777  C CE1 . PHE A 1 126 ? 160.553 153.300 154.751 1.00 52.43  ? 126 PHE B CE1 1 
ATOM   778  C CE2 . PHE A 1 126 ? 162.585 152.146 155.247 1.00 52.43  ? 126 PHE B CE2 1 
ATOM   779  C CZ  . PHE A 1 126 ? 161.776 153.256 155.388 1.00 52.43  ? 126 PHE B CZ  1 
ATOM   780  N N   . LEU A 1 127 ? 159.249 147.048 152.394 1.00 49.96  ? 127 LEU B N   1 
ATOM   781  C CA  . LEU A 1 127 ? 158.761 146.015 151.488 1.00 49.96  ? 127 LEU B CA  1 
ATOM   782  C C   . LEU A 1 127 ? 157.257 145.831 151.621 1.00 49.96  ? 127 LEU B C   1 
ATOM   783  O O   . LEU A 1 127 ? 156.517 145.852 150.632 1.00 49.96  ? 127 LEU B O   1 
ATOM   784  C CB  . LEU A 1 127 ? 159.490 144.702 151.793 1.00 49.96  ? 127 LEU B CB  1 
ATOM   785  C CG  . LEU A 1 127 ? 159.368 143.436 150.949 1.00 49.96  ? 127 LEU B CG  1 
ATOM   786  C CD1 . LEU A 1 127 ? 160.633 142.623 151.117 1.00 49.96  ? 127 LEU B CD1 1 
ATOM   787  C CD2 . LEU A 1 127 ? 158.166 142.607 151.361 1.00 49.96  ? 127 LEU B CD2 1 
ATOM   788  N N   . GLU A 1 128 ? 156.796 145.652 152.857 1.00 56.47  ? 128 GLU B N   1 
ATOM   789  C CA  . GLU A 1 128 ? 155.374 145.452 153.103 1.00 56.47  ? 128 GLU B CA  1 
ATOM   790  C C   . GLU A 1 128 ? 154.568 146.741 153.015 1.00 56.47  ? 128 GLU B C   1 
ATOM   791  O O   . GLU A 1 128 ? 153.380 146.686 152.682 1.00 56.47  ? 128 GLU B O   1 
ATOM   792  C CB  . GLU A 1 128 ? 155.162 144.788 154.463 1.00 56.47  ? 128 GLU B CB  1 
ATOM   793  C CG  . GLU A 1 128 ? 153.988 143.820 154.483 1.00 56.47  ? 128 GLU B CG  1 
ATOM   794  C CD  . GLU A 1 128 ? 154.182 142.614 153.574 1.00 56.47  ? 128 GLU B CD  1 
ATOM   795  O OE1 . GLU A 1 128 ? 155.334 142.316 153.195 1.00 56.47  ? 128 GLU B OE1 1 
ATOM   796  O OE2 . GLU A 1 128 ? 153.173 141.965 153.231 1.00 56.47  ? 128 GLU B OE2 1 
ATOM   797  N N   . PHE A 1 129 ? 155.179 147.895 153.290 1.00 56.68  ? 129 PHE B N   1 
ATOM   798  C CA  . PHE A 1 129 ? 154.508 149.164 153.028 1.00 56.68  ? 129 PHE B CA  1 
ATOM   799  C C   . PHE A 1 129 ? 154.182 149.311 151.549 1.00 56.68  ? 129 PHE B C   1 
ATOM   800  O O   . PHE A 1 129 ? 153.111 149.814 151.182 1.00 56.68  ? 129 PHE B O   1 
ATOM   801  C CB  . PHE A 1 129 ? 155.386 150.322 153.506 1.00 56.68  ? 129 PHE B CB  1 
ATOM   802  C CG  . PHE A 1 129 ? 154.990 151.656 152.946 1.00 56.68  ? 129 PHE B CG  1 
ATOM   803  C CD1 . PHE A 1 129 ? 153.813 152.266 153.338 1.00 56.68  ? 129 PHE B CD1 1 
ATOM   804  C CD2 . PHE A 1 129 ? 155.804 152.306 152.036 1.00 56.68  ? 129 PHE B CD2 1 
ATOM   805  C CE1 . PHE A 1 129 ? 153.447 153.495 152.824 1.00 56.68  ? 129 PHE B CE1 1 
ATOM   806  C CE2 . PHE A 1 129 ? 155.445 153.536 151.521 1.00 56.68  ? 129 PHE B CE2 1 
ATOM   807  C CZ  . PHE A 1 129 ? 154.266 154.131 151.916 1.00 56.68  ? 129 PHE B CZ  1 
ATOM   808  N N   . PHE A 1 130 ? 155.101 148.881 150.686 1.00 55.06  ? 130 PHE B N   1 
ATOM   809  C CA  . PHE A 1 130 ? 154.842 148.918 149.253 1.00 55.06  ? 130 PHE B CA  1 
ATOM   810  C C   . PHE A 1 130 ? 153.689 147.994 148.877 1.00 55.06  ? 130 PHE B C   1 
ATOM   811  O O   . PHE A 1 130 ? 152.838 148.354 148.055 1.00 55.06  ? 130 PHE B O   1 
ATOM   812  C CB  . PHE A 1 130 ? 156.113 148.554 148.488 1.00 55.06  ? 130 PHE B CB  1 
ATOM   813  C CG  . PHE A 1 130 ? 157.054 149.710 148.306 1.00 55.06  ? 130 PHE B CG  1 
ATOM   814  C CD1 . PHE A 1 130 ? 156.583 150.938 147.874 1.00 55.06  ? 130 PHE B CD1 1 
ATOM   815  C CD2 . PHE A 1 130 ? 158.404 149.572 148.576 1.00 55.06  ? 130 PHE B CD2 1 
ATOM   816  C CE1 . PHE A 1 130 ? 157.442 152.004 147.707 1.00 55.06  ? 130 PHE B CE1 1 
ATOM   817  C CE2 . PHE A 1 130 ? 159.268 150.635 148.414 1.00 55.06  ? 130 PHE B CE2 1 
ATOM   818  C CZ  . PHE A 1 130 ? 158.787 151.852 147.979 1.00 55.06  ? 130 PHE B CZ  1 
ATOM   819  N N   . TYR A 1 131 ? 153.635 146.803 149.475 1.00 58.22  ? 131 TYR B N   1 
ATOM   820  C CA  . TYR A 1 131 ? 152.512 145.910 149.205 1.00 58.22  ? 131 TYR B CA  1 
ATOM   821  C C   . TYR A 1 131 ? 151.202 146.518 149.686 1.00 58.22  ? 131 TYR B C   1 
ATOM   822  O O   . TYR A 1 131 ? 150.157 146.334 149.055 1.00 58.22  ? 131 TYR B O   1 
ATOM   823  C CB  . TYR A 1 131 ? 152.740 144.548 149.858 1.00 58.22  ? 131 TYR B CB  1 
ATOM   824  C CG  . TYR A 1 131 ? 151.638 143.554 149.566 1.00 58.22  ? 131 TYR B CG  1 
ATOM   825  C CD1 . TYR A 1 131 ? 151.600 142.865 148.362 1.00 58.22  ? 131 TYR B CD1 1 
ATOM   826  C CD2 . TYR A 1 131 ? 150.632 143.309 150.489 1.00 58.22  ? 131 TYR B CD2 1 
ATOM   827  C CE1 . TYR A 1 131 ? 150.593 141.960 148.089 1.00 58.22  ? 131 TYR B CE1 1 
ATOM   828  C CE2 . TYR A 1 131 ? 149.624 142.407 150.223 1.00 58.22  ? 131 TYR B CE2 1 
ATOM   829  C CZ  . TYR A 1 131 ? 149.609 141.735 149.025 1.00 58.22  ? 131 TYR B CZ  1 
ATOM   830  O OH  . TYR A 1 131 ? 148.602 140.836 148.765 1.00 58.22  ? 131 TYR B OH  1 
ATOM   831  N N   . GLY A 1 132 ? 151.237 147.235 150.806 1.00 61.63  ? 132 GLY B N   1 
ATOM   832  C CA  . GLY A 1 132 ? 150.053 147.905 151.306 1.00 61.63  ? 132 GLY B CA  1 
ATOM   833  C C   . GLY A 1 132 ? 149.548 148.991 150.379 1.00 61.63  ? 132 GLY B C   1 
ATOM   834  O O   . GLY A 1 132 ? 148.346 149.070 150.097 1.00 61.63  ? 132 GLY B O   1 
ATOM   835  N N   . ILE A 1 133 ? 150.461 149.837 149.893 1.00 66.34  ? 133 ILE B N   1 
ATOM   836  C CA  . ILE A 1 133 ? 150.055 150.881 148.957 1.00 66.34  ? 133 ILE B CA  1 
ATOM   837  C C   . ILE A 1 133 ? 149.636 150.281 147.619 1.00 66.34  ? 133 ILE B C   1 
ATOM   838  O O   . ILE A 1 133 ? 148.874 150.905 146.872 1.00 66.34  ? 133 ILE B O   1 
ATOM   839  C CB  . ILE A 1 133 ? 151.168 151.943 148.791 1.00 66.34  ? 133 ILE B CB  1 
ATOM   840  C CG1 . ILE A 1 133 ? 150.607 153.218 148.154 1.00 66.34  ? 133 ILE B CG1 1 
ATOM   841  C CG2 . ILE A 1 133 ? 152.319 151.421 147.968 1.00 66.34  ? 133 ILE B CG2 1 
ATOM   842  C CD1 . ILE A 1 133 ? 151.616 154.338 148.033 1.00 66.34  ? 133 ILE B CD1 1 
ATOM   843  N N   . ALA A 1 134 ? 150.106 149.072 147.299 1.00 66.29  ? 134 ALA B N   1 
ATOM   844  C CA  . ALA A 1 134 ? 149.591 148.366 146.130 1.00 66.29  ? 134 ALA B CA  1 
ATOM   845  C C   . ALA A 1 134 ? 148.162 147.889 146.361 1.00 66.29  ? 134 ALA B C   1 
ATOM   846  O O   . ALA A 1 134 ? 147.284 148.083 145.511 1.00 66.29  ? 134 ALA B O   1 
ATOM   847  C CB  . ALA A 1 134 ? 150.498 147.183 145.789 1.00 66.29  ? 134 ALA B CB  1 
ATOM   848  N N   . THR A 1 135 ? 147.914 147.262 147.513 1.00 64.38  ? 135 THR B N   1 
ATOM   849  C CA  . THR A 1 135 ? 146.597 146.703 147.803 1.00 64.38  ? 135 THR B CA  1 
ATOM   850  C C   . THR A 1 135 ? 145.552 147.796 147.984 1.00 64.38  ? 135 THR B C   1 
ATOM   851  O O   . THR A 1 135 ? 144.359 147.557 147.759 1.00 64.38  ? 135 THR B O   1 
ATOM   852  C CB  . THR A 1 135 ? 146.673 145.818 149.049 1.00 64.38  ? 135 THR B CB  1 
ATOM   853  O OG1 . THR A 1 135 ? 147.782 144.919 148.928 1.00 64.38  ? 135 THR B OG1 1 
ATOM   854  C CG2 . THR A 1 135 ? 145.401 145.001 149.211 1.00 64.38  ? 135 THR B CG2 1 
ATOM   855  N N   . ALA A 1 136 ? 145.977 149.000 148.368 1.00 67.19  ? 136 ALA B N   1 
ATOM   856  C CA  . ALA A 1 136 ? 145.039 150.101 148.556 1.00 67.19  ? 136 ALA B CA  1 
ATOM   857  C C   . ALA A 1 136 ? 144.364 150.543 147.263 1.00 67.19  ? 136 ALA B C   1 
ATOM   858  O O   . ALA A 1 136 ? 143.384 151.294 147.327 1.00 67.19  ? 136 ALA B O   1 
ATOM   859  C CB  . ALA A 1 136 ? 145.754 151.292 149.195 1.00 67.19  ? 136 ALA B CB  1 
ATOM   860  N N   . THR A 1 137 ? 144.858 150.109 146.103 1.00 66.40  ? 137 THR B N   1 
ATOM   861  C CA  . THR A 1 137 ? 144.333 150.531 144.810 1.00 66.40  ? 137 THR B CA  1 
ATOM   862  C C   . THR A 1 137 ? 143.459 149.475 144.138 1.00 66.40  ? 137 THR B C   1 
ATOM   863  O O   . THR A 1 137 ? 143.022 149.679 142.998 1.00 66.40  ? 137 THR B O   1 
ATOM   864  C CB  . THR A 1 137 ? 145.487 150.921 143.888 1.00 66.40  ? 137 THR B CB  1 
ATOM   865  O OG1 . THR A 1 137 ? 146.451 149.862 143.868 1.00 66.40  ? 137 THR B OG1 1 
ATOM   866  C CG2 . THR A 1 137 ? 146.152 152.194 144.385 1.00 66.40  ? 137 THR B CG2 1 
ATOM   867  N N   . GLU A 1 138 ? 143.188 148.355 144.811 1.00 67.39  ? 138 GLU B N   1 
ATOM   868  C CA  . GLU A 1 138 ? 142.239 147.388 144.268 1.00 67.39  ? 138 GLU B CA  1 
ATOM   869  C C   . GLU A 1 138 ? 140.840 147.986 144.186 1.00 67.39  ? 138 GLU B C   1 
ATOM   870  O O   . GLU A 1 138 ? 140.091 147.715 143.237 1.00 67.39  ? 138 GLU B O   1 
ATOM   871  C CB  . GLU A 1 138 ? 142.235 146.117 145.117 1.00 67.39  ? 138 GLU B CB  1 
ATOM   872  C CG  . GLU A 1 138 ? 143.477 145.255 144.953 1.00 67.39  ? 138 GLU B CG  1 
ATOM   873  C CD  . GLU A 1 138 ? 143.354 144.258 143.817 1.00 67.39  ? 138 GLU B CD  1 
ATOM   874  O OE1 . GLU A 1 138 ? 142.384 144.357 143.037 1.00 67.39  ? 138 GLU B OE1 1 
ATOM   875  O OE2 . GLU A 1 138 ? 144.229 143.373 143.705 1.00 67.39  ? 138 GLU B OE2 1 
ATOM   876  N N   . ILE A 1 139 ? 140.469 148.799 145.177 1.00 66.84  ? 139 ILE B N   1 
ATOM   877  C CA  . ILE A 1 139 ? 139.195 149.509 145.127 1.00 66.84  ? 139 ILE B CA  1 
ATOM   878  C C   . ILE A 1 139 ? 139.156 150.440 143.924 1.00 66.84  ? 139 ILE B C   1 
ATOM   879  O O   . ILE A 1 139 ? 138.134 150.547 143.235 1.00 66.84  ? 139 ILE B O   1 
ATOM   880  C CB  . ILE A 1 139 ? 138.956 150.270 146.445 1.00 66.84  ? 139 ILE B CB  1 
ATOM   881  C CG1 . ILE A 1 139 ? 140.209 151.051 146.851 1.00 66.84  ? 139 ILE B CG1 1 
ATOM   882  C CG2 . ILE A 1 139 ? 138.546 149.307 147.550 1.00 66.84  ? 139 ILE B CG2 1 
ATOM   883  C CD1 . ILE A 1 139 ? 140.000 151.996 148.012 1.00 66.84  ? 139 ILE B CD1 1 
ATOM   884  N N   . ALA A 1 140 ? 140.268 151.126 143.651 1.00 68.88  ? 140 ALA B N   1 
ATOM   885  C CA  . ALA A 1 140 ? 140.336 152.005 142.490 1.00 68.88  ? 140 ALA B CA  1 
ATOM   886  C C   . ALA A 1 140 ? 140.170 151.221 141.197 1.00 68.88  ? 140 ALA B C   1 
ATOM   887  O O   . ALA A 1 140 ? 139.456 151.656 140.286 1.00 68.88  ? 140 ALA B O   1 
ATOM   888  C CB  . ALA A 1 140 ? 141.661 152.763 142.490 1.00 68.88  ? 140 ALA B CB  1 
ATOM   889  N N   . TYR A 1 141 ? 140.822 150.060 141.101 1.00 63.01  ? 141 TYR B N   1 
ATOM   890  C CA  . TYR A 1 141 ? 140.641 149.202 139.933 1.00 63.01  ? 141 TYR B CA  1 
ATOM   891  C C   . TYR A 1 141 ? 139.184 148.802 139.753 1.00 63.01  ? 141 TYR B C   1 
ATOM   892  O O   . TYR A 1 141 ? 138.620 148.941 138.662 1.00 63.01  ? 141 TYR B O   1 
ATOM   893  C CB  . TYR A 1 141 ? 141.511 147.953 140.044 1.00 63.01  ? 141 TYR B CB  1 
ATOM   894  C CG  . TYR A 1 141 ? 141.373 147.050 138.843 1.00 63.01  ? 141 TYR B CG  1 
ATOM   895  C CD1 . TYR A 1 141 ? 141.978 147.362 137.635 1.00 63.01  ? 141 TYR B CD1 1 
ATOM   896  C CD2 . TYR A 1 141 ? 140.614 145.888 138.914 1.00 63.01  ? 141 TYR B CD2 1 
ATOM   897  C CE1 . TYR A 1 141 ? 141.838 146.537 136.533 1.00 63.01  ? 141 TYR B CE1 1 
ATOM   898  C CE2 . TYR A 1 141 ? 140.471 145.058 137.820 1.00 63.01  ? 141 TYR B CE2 1 
ATOM   899  C CZ  . TYR A 1 141 ? 141.087 145.387 136.632 1.00 63.01  ? 141 TYR B CZ  1 
ATOM   900  O OH  . TYR A 1 141 ? 140.948 144.566 135.537 1.00 63.01  ? 141 TYR B OH  1 
ATOM   901  N N   . TYR A 1 142 ? 138.557 148.299 140.815 1.00 69.35  ? 142 TYR B N   1 
ATOM   902  C CA  . TYR A 1 142 ? 137.199 147.788 140.679 1.00 69.35  ? 142 TYR B CA  1 
ATOM   903  C C   . TYR A 1 142 ? 136.176 148.899 140.489 1.00 69.35  ? 142 TYR B C   1 
ATOM   904  O O   . TYR A 1 142 ? 135.080 148.633 139.984 1.00 69.35  ? 142 TYR B O   1 
ATOM   905  C CB  . TYR A 1 142 ? 136.836 146.932 141.890 1.00 69.35  ? 142 TYR B CB  1 
ATOM   906  C CG  . TYR A 1 142 ? 137.394 145.532 141.807 1.00 69.35  ? 142 TYR B CG  1 
ATOM   907  C CD1 . TYR A 1 142 ? 136.894 144.617 140.892 1.00 69.35  ? 142 TYR B CD1 1 
ATOM   908  C CD2 . TYR A 1 142 ? 138.431 145.131 142.636 1.00 69.35  ? 142 TYR B CD2 1 
ATOM   909  C CE1 . TYR A 1 142 ? 137.409 143.337 140.811 1.00 69.35  ? 142 TYR B CE1 1 
ATOM   910  C CE2 . TYR A 1 142 ? 138.952 143.856 142.562 1.00 69.35  ? 142 TYR B CE2 1 
ATOM   911  C CZ  . TYR A 1 142 ? 138.438 142.963 141.650 1.00 69.35  ? 142 TYR B CZ  1 
ATOM   912  O OH  . TYR A 1 142 ? 138.960 141.694 141.581 1.00 69.35  ? 142 TYR B OH  1 
ATOM   913  N N   . SER A 1 143 ? 136.503 150.133 140.874 1.00 65.75  ? 143 SER B N   1 
ATOM   914  C CA  . SER A 1 143 ? 135.576 151.242 140.710 1.00 65.75  ? 143 SER B CA  1 
ATOM   915  C C   . SER A 1 143 ? 135.782 152.009 139.412 1.00 65.75  ? 143 SER B C   1 
ATOM   916  O O   . SER A 1 143 ? 134.848 152.675 138.951 1.00 65.75  ? 143 SER B O   1 
ATOM   917  C CB  . SER A 1 143 ? 135.694 152.205 141.895 1.00 65.75  ? 143 SER B CB  1 
ATOM   918  O OG  . SER A 1 143 ? 134.822 153.311 141.743 1.00 65.75  ? 143 SER B OG  1 
ATOM   919  N N   . TYR A 1 144 ? 136.974 151.933 138.813 1.00 58.79  ? 144 TYR B N   1 
ATOM   920  C CA  . TYR A 1 144 ? 137.206 152.603 137.537 1.00 58.79  ? 144 TYR B CA  1 
ATOM   921  C C   . TYR A 1 144 ? 136.300 152.055 136.443 1.00 58.79  ? 144 TYR B C   1 
ATOM   922  O O   . TYR A 1 144 ? 135.946 152.782 135.508 1.00 58.79  ? 144 TYR B O   1 
ATOM   923  C CB  . TYR A 1 144 ? 138.675 152.459 137.135 1.00 58.79  ? 144 TYR B CB  1 
ATOM   924  C CG  . TYR A 1 144 ? 138.945 152.689 135.664 1.00 58.79  ? 144 TYR B CG  1 
ATOM   925  C CD1 . TYR A 1 144 ? 138.759 153.937 135.087 1.00 58.79  ? 144 TYR B CD1 1 
ATOM   926  C CD2 . TYR A 1 144 ? 139.373 151.649 134.850 1.00 58.79  ? 144 TYR B CD2 1 
ATOM   927  C CE1 . TYR A 1 144 ? 138.998 154.142 133.743 1.00 58.79  ? 144 TYR B CE1 1 
ATOM   928  C CE2 . TYR A 1 144 ? 139.616 151.847 133.505 1.00 58.79  ? 144 TYR B CE2 1 
ATOM   929  C CZ  . TYR A 1 144 ? 139.427 153.094 132.956 1.00 58.79  ? 144 TYR B CZ  1 
ATOM   930  O OH  . TYR A 1 144 ? 139.669 153.293 131.616 1.00 58.79  ? 144 TYR B OH  1 
ATOM   931  N N   . ILE A 1 145 ? 135.901 150.786 136.556 1.00 62.84  ? 145 ILE B N   1 
ATOM   932  C CA  . ILE A 1 145 ? 135.112 150.149 135.507 1.00 62.84  ? 145 ILE B CA  1 
ATOM   933  C C   . ILE A 1 145 ? 133.798 150.892 135.309 1.00 62.84  ? 145 ILE B C   1 
ATOM   934  O O   . ILE A 1 145 ? 133.315 151.047 134.180 1.00 62.84  ? 145 ILE B O   1 
ATOM   935  C CB  . ILE A 1 145 ? 134.882 148.666 135.852 1.00 62.84  ? 145 ILE B CB  1 
ATOM   936  C CG1 . ILE A 1 145 ? 136.222 147.946 136.009 1.00 62.84  ? 145 ILE B CG1 1 
ATOM   937  C CG2 . ILE A 1 145 ? 134.053 147.986 134.776 1.00 62.84  ? 145 ILE B CG2 1 
ATOM   938  C CD1 . ILE A 1 145 ? 137.068 147.955 134.769 1.00 62.84  ? 145 ILE B CD1 1 
ATOM   939  N N   . TYR A 1 146 ? 133.209 151.381 136.403 1.00 63.91  ? 146 TYR B N   1 
ATOM   940  C CA  . TYR A 1 146 ? 131.974 152.149 136.320 1.00 63.91  ? 146 TYR B CA  1 
ATOM   941  C C   . TYR A 1 146 ? 132.156 153.478 135.594 1.00 63.91  ? 146 TYR B C   1 
ATOM   942  O O   . TYR A 1 146 ? 131.174 154.033 135.087 1.00 63.91  ? 146 TYR B O   1 
ATOM   943  C CB  . TYR A 1 146 ? 131.422 152.399 137.727 1.00 63.91  ? 146 TYR B CB  1 
ATOM   944  C CG  . TYR A 1 146 ? 130.145 153.210 137.749 1.00 63.91  ? 146 TYR B CG  1 
ATOM   945  C CD1 . TYR A 1 146 ? 128.953 152.677 137.275 1.00 63.91  ? 146 TYR B CD1 1 
ATOM   946  C CD2 . TYR A 1 146 ? 130.136 154.514 138.224 1.00 63.91  ? 146 TYR B CD2 1 
ATOM   947  C CE1 . TYR A 1 146 ? 127.787 153.414 137.285 1.00 63.91  ? 146 TYR B CE1 1 
ATOM   948  C CE2 . TYR A 1 146 ? 128.973 155.260 138.238 1.00 63.91  ? 146 TYR B CE2 1 
ATOM   949  C CZ  . TYR A 1 146 ? 127.802 154.705 137.767 1.00 63.91  ? 146 TYR B CZ  1 
ATOM   950  O OH  . TYR A 1 146 ? 126.639 155.441 137.777 1.00 63.91  ? 146 TYR B OH  1 
ATOM   951  N N   . SER A 1 147 ? 133.380 153.992 135.514 1.00 58.05  ? 147 SER B N   1 
ATOM   952  C CA  . SER A 1 147 ? 133.620 155.333 135.000 1.00 58.05  ? 147 SER B CA  1 
ATOM   953  C C   . SER A 1 147 ? 133.776 155.392 133.485 1.00 58.05  ? 147 SER B C   1 
ATOM   954  O O   . SER A 1 147 ? 133.972 156.485 132.946 1.00 58.05  ? 147 SER B O   1 
ATOM   955  C CB  . SER A 1 147 ? 134.866 155.931 135.658 1.00 58.05  ? 147 SER B CB  1 
ATOM   956  O OG  . SER A 1 147 ? 135.174 157.197 135.103 1.00 58.05  ? 147 SER B OG  1 
ATOM   957  N N   . VAL A 1 148 ? 133.705 154.261 132.785 1.00 61.32  ? 148 VAL B N   1 
ATOM   958  C CA  . VAL A 1 148 ? 133.902 154.262 131.337 1.00 61.32  ? 148 VAL B CA  1 
ATOM   959  C C   . VAL A 1 148 ? 132.810 153.536 130.569 1.00 61.32  ? 148 VAL B C   1 
ATOM   960  O O   . VAL A 1 148 ? 132.653 153.781 129.358 1.00 61.32  ? 148 VAL B O   1 
ATOM   961  C CB  . VAL A 1 148 ? 135.280 153.664 130.981 1.00 61.32  ? 148 VAL B CB  1 
ATOM   962  C CG1 . VAL A 1 148 ? 136.392 154.622 131.366 1.00 61.32  ? 148 VAL B CG1 1 
ATOM   963  C CG2 . VAL A 1 148 ? 135.459 152.317 131.665 1.00 61.32  ? 148 VAL B CG2 1 
ATOM   964  N N   . VAL A 1 149 ? 132.029 152.652 131.184 1.00 68.31  ? 149 VAL B N   1 
ATOM   965  C CA  . VAL A 1 149 ? 131.074 151.823 130.464 1.00 68.31  ? 149 VAL B CA  1 
ATOM   966  C C   . VAL A 1 149 ? 129.659 152.232 130.859 1.00 68.31  ? 149 VAL B C   1 
ATOM   967  O O   . VAL A 1 149 ? 129.441 152.942 131.842 1.00 68.31  ? 149 VAL B O   1 
ATOM   968  C CB  . VAL A 1 149 ? 131.300 150.321 130.718 1.00 68.31  ? 149 VAL B CB  1 
ATOM   969  C CG1 . VAL A 1 149 ? 132.753 149.956 130.458 1.00 68.31  ? 149 VAL B CG1 1 
ATOM   970  C CG2 . VAL A 1 149 ? 130.894 149.959 132.137 1.00 68.31  ? 149 VAL B CG2 1 
ATOM   971  N N   . ASP A 1 150 ? 128.693 151.768 130.069 1.00 71.26  ? 150 ASP B N   1 
ATOM   972  C CA  . ASP A 1 150 ? 127.294 152.089 130.310 1.00 71.26  ? 150 ASP B CA  1 
ATOM   973  C C   . ASP A 1 150 ? 126.823 151.495 131.633 1.00 71.26  ? 150 ASP B C   1 
ATOM   974  O O   . ASP A 1 150 ? 127.299 150.446 132.075 1.00 71.26  ? 150 ASP B O   1 
ATOM   975  C CB  . ASP A 1 150 ? 126.424 151.574 129.166 1.00 71.26  ? 150 ASP B CB  1 
ATOM   976  N N   . LEU A 1 151 ? 125.879 152.192 132.271 1.00 71.46  ? 151 LEU B N   1 
ATOM   977  C CA  . LEU A 1 151 ? 125.400 151.772 133.585 1.00 71.46  ? 151 LEU B CA  1 
ATOM   978  C C   . LEU A 1 151 ? 124.720 150.411 133.523 1.00 71.46  ? 151 LEU B C   1 
ATOM   979  O O   . LEU A 1 151 ? 124.936 149.560 134.395 1.00 71.46  ? 151 LEU B O   1 
ATOM   980  C CB  . LEU A 1 151 ? 124.446 152.822 134.154 1.00 71.46  ? 151 LEU B CB  1 
ATOM   981  N N   . GLY A 1 152 ? 123.887 150.188 132.505 1.00 77.57  ? 152 GLY B N   1 
ATOM   982  C CA  . GLY A 1 152 ? 123.242 148.894 132.365 1.00 77.57  ? 152 GLY B CA  1 
ATOM   983  C C   . GLY A 1 152 ? 124.236 147.776 132.126 1.00 77.57  ? 152 GLY B C   1 
ATOM   984  O O   . GLY A 1 152 ? 124.112 146.689 132.694 1.00 77.57  ? 152 GLY B O   1 
ATOM   985  N N   . MET A 1 153 ? 125.243 148.032 131.290 1.00 78.27  ? 153 MET B N   1 
ATOM   986  C CA  . MET A 1 153 ? 126.281 147.049 131.007 1.00 78.27  ? 153 MET B CA  1 
ATOM   987  C C   . MET A 1 153 ? 127.352 146.989 132.086 1.00 78.27  ? 153 MET B C   1 
ATOM   988  O O   . MET A 1 153 ? 128.198 146.088 132.046 1.00 78.27  ? 153 MET B O   1 
ATOM   989  C CB  . MET A 1 153 ? 126.933 147.349 129.655 1.00 78.27  ? 153 MET B CB  1 
ATOM   990  N N   . TYR A 1 154 ? 127.339 147.924 133.039 1.00 81.06  ? 154 TYR B N   1 
ATOM   991  C CA  . TYR A 1 154 ? 128.356 147.933 134.084 1.00 81.06  ? 154 TYR B CA  1 
ATOM   992  C C   . TYR A 1 154 ? 128.287 146.671 134.932 1.00 81.06  ? 154 TYR B C   1 
ATOM   993  O O   . TYR A 1 154 ? 129.322 146.088 135.271 1.00 81.06  ? 154 TYR B O   1 
ATOM   994  C CB  . TYR A 1 154 ? 128.198 149.176 134.958 1.00 81.06  ? 154 TYR B CB  1 
ATOM   995  N N   . GLN A 1 155 ? 127.076 146.231 135.279 1.00 83.33  ? 155 GLN B N   1 
ATOM   996  C CA  . GLN A 1 155 ? 126.928 145.043 136.114 1.00 83.33  ? 155 GLN B CA  1 
ATOM   997  C C   . GLN A 1 155 ? 127.480 143.805 135.418 1.00 83.33  ? 155 GLN B C   1 
ATOM   998  O O   . GLN A 1 155 ? 128.225 143.021 136.018 1.00 83.33  ? 155 GLN B O   1 
ATOM   999  C CB  . GLN A 1 155 ? 125.457 144.845 136.483 1.00 83.33  ? 155 GLN B CB  1 
ATOM   1000 N N   . LYS A 1 156 ? 127.143 143.619 134.140 1.00 82.12  ? 156 LYS B N   1 
ATOM   1001 C CA  . LYS A 1 156 ? 127.617 142.430 133.438 1.00 82.12  ? 156 LYS B CA  1 
ATOM   1002 C C   . LYS A 1 156 ? 129.123 142.486 133.203 1.00 82.12  ? 156 LYS B C   1 
ATOM   1003 O O   . LYS A 1 156 ? 129.813 141.467 133.347 1.00 82.12  ? 156 LYS B O   1 
ATOM   1004 C CB  . LYS A 1 156 ? 126.858 142.244 132.121 1.00 82.12  ? 156 LYS B CB  1 
ATOM   1005 C CG  . LYS A 1 156 ? 126.751 143.486 131.259 1.00 82.12  ? 156 LYS B CG  1 
ATOM   1006 C CD  . LYS A 1 156 ? 125.580 143.411 130.291 1.00 82.12  ? 156 LYS B CD  1 
ATOM   1007 C CE  . LYS A 1 156 ? 124.306 143.950 130.919 1.00 82.12  ? 156 LYS B CE  1 
ATOM   1008 N NZ  . LYS A 1 156 ? 123.237 144.172 129.907 1.00 82.12  ? 156 LYS B NZ  1 
ATOM   1009 N N   . VAL A 1 157 ? 129.665 143.662 132.867 1.00 86.62  ? 157 VAL B N   1 
ATOM   1010 C CA  . VAL A 1 157 ? 131.105 143.718 132.630 1.00 86.62  ? 157 VAL B CA  1 
ATOM   1011 C C   . VAL A 1 157 ? 131.881 143.555 133.934 1.00 86.62  ? 157 VAL B C   1 
ATOM   1012 O O   . VAL A 1 157 ? 132.960 142.954 133.941 1.00 86.62  ? 157 VAL B O   1 
ATOM   1013 C CB  . VAL A 1 157 ? 131.512 145.002 131.876 1.00 86.62  ? 157 VAL B CB  1 
ATOM   1014 C CG1 . VAL A 1 157 ? 130.796 145.086 130.532 1.00 86.62  ? 157 VAL B CG1 1 
ATOM   1015 C CG2 . VAL A 1 157 ? 131.270 146.247 132.711 1.00 86.62  ? 157 VAL B CG2 1 
ATOM   1016 N N   . THR A 1 158 ? 131.359 144.054 135.060 1.00 79.87  ? 158 THR B N   1 
ATOM   1017 C CA  . THR A 1 158 ? 132.071 143.836 136.313 1.00 79.87  ? 158 THR B CA  1 
ATOM   1018 C C   . THR A 1 158 ? 131.917 142.402 136.801 1.00 79.87  ? 158 THR B C   1 
ATOM   1019 O O   . THR A 1 158 ? 132.824 141.881 137.457 1.00 79.87  ? 158 THR B O   1 
ATOM   1020 C CB  . THR A 1 158 ? 131.617 144.836 137.386 1.00 79.87  ? 158 THR B CB  1 
ATOM   1021 O OG1 . THR A 1 158 ? 132.522 144.786 138.496 1.00 79.87  ? 158 THR B OG1 1 
ATOM   1022 C CG2 . THR A 1 158 ? 130.217 144.537 137.885 1.00 79.87  ? 158 THR B CG2 1 
ATOM   1023 N N   . SER A 1 159 ? 130.806 141.738 136.468 1.00 79.67  ? 159 SER B N   1 
ATOM   1024 C CA  . SER A 1 159 ? 130.712 140.306 136.726 1.00 79.67  ? 159 SER B CA  1 
ATOM   1025 C C   . SER A 1 159 ? 131.761 139.546 135.930 1.00 79.67  ? 159 SER B C   1 
ATOM   1026 O O   . SER A 1 159 ? 132.428 138.648 136.459 1.00 79.67  ? 159 SER B O   1 
ATOM   1027 C CB  . SER A 1 159 ? 129.311 139.802 136.387 1.00 79.67  ? 159 SER B CB  1 
ATOM   1028 O OG  . SER A 1 159 ? 129.058 139.913 134.998 1.00 79.67  ? 159 SER B OG  1 
ATOM   1029 N N   . TYR A 1 160 ? 131.935 139.913 134.658 1.00 81.51  ? 160 TYR B N   1 
ATOM   1030 C CA  . TYR A 1 160 ? 132.980 139.299 133.846 1.00 81.51  ? 160 TYR B CA  1 
ATOM   1031 C C   . TYR A 1 160 ? 134.363 139.587 134.420 1.00 81.51  ? 160 TYR B C   1 
ATOM   1032 O O   . TYR A 1 160 ? 135.242 138.720 134.406 1.00 81.51  ? 160 TYR B O   1 
ATOM   1033 C CB  . TYR A 1 160 ? 132.883 139.794 132.403 1.00 81.51  ? 160 TYR B CB  1 
ATOM   1034 N N   . CYS A 1 161 ? 134.569 140.800 134.935 1.00 84.40  ? 161 CYS B N   1 
ATOM   1035 C CA  . CYS A 1 161 ? 135.861 141.163 135.508 1.00 84.40  ? 161 CYS B CA  1 
ATOM   1036 C C   . CYS A 1 161 ? 136.170 140.346 136.759 1.00 84.40  ? 161 CYS B C   1 
ATOM   1037 O O   . CYS A 1 161 ? 137.282 139.827 136.911 1.00 84.40  ? 161 CYS B O   1 
ATOM   1038 C CB  . CYS A 1 161 ? 135.893 142.660 135.820 1.00 84.40  ? 161 CYS B CB  1 
ATOM   1039 S SG  . CYS A 1 161 ? 136.084 143.721 134.370 1.00 84.40  ? 161 CYS B SG  1 
ATOM   1040 N N   . ARG A 1 162 ? 135.203 140.228 137.676 1.00 78.21  ? 162 ARG B N   1 
ATOM   1041 C CA  . ARG A 1 162 ? 135.447 139.415 138.865 1.00 78.21  ? 162 ARG B CA  1 
ATOM   1042 C C   . ARG A 1 162 ? 135.609 137.942 138.515 1.00 78.21  ? 162 ARG B C   1 
ATOM   1043 O O   . ARG A 1 162 ? 136.402 137.242 139.156 1.00 78.21  ? 162 ARG B O   1 
ATOM   1044 C CB  . ARG A 1 162 ? 134.340 139.589 139.908 1.00 78.21  ? 162 ARG B CB  1 
ATOM   1045 C CG  . ARG A 1 162 ? 133.922 141.020 140.191 1.00 78.21  ? 162 ARG B CG  1 
ATOM   1046 C CD  . ARG A 1 162 ? 132.556 141.064 140.866 1.00 78.21  ? 162 ARG B CD  1 
ATOM   1047 N NE  . ARG A 1 162 ? 131.433 141.134 139.939 1.00 78.21  ? 162 ARG B NE  1 
ATOM   1048 C CZ  . ARG A 1 162 ? 130.284 141.738 140.211 1.00 78.21  ? 162 ARG B CZ  1 
ATOM   1049 N NH1 . ARG A 1 162 ? 130.087 142.360 141.362 1.00 78.21  ? 162 ARG B NH1 1 
ATOM   1050 N NH2 . ARG A 1 162 ? 129.305 141.711 139.312 1.00 78.21  ? 162 ARG B NH2 1 
ATOM   1051 N N   . SER A 1 163 ? 134.882 137.454 137.507 1.00 78.03  ? 163 SER B N   1 
ATOM   1052 C CA  . SER A 1 163 ? 135.096 136.085 137.053 1.00 78.03  ? 163 SER B CA  1 
ATOM   1053 C C   . SER A 1 163 ? 136.507 135.906 136.514 1.00 78.03  ? 163 SER B C   1 
ATOM   1054 O O   . SER A 1 163 ? 137.152 134.882 136.767 1.00 78.03  ? 163 SER B O   1 
ATOM   1055 C CB  . SER A 1 163 ? 134.068 135.718 135.987 1.00 78.03  ? 163 SER B CB  1 
ATOM   1056 O OG  . SER A 1 163 ? 134.283 136.469 134.807 1.00 78.03  ? 163 SER B OG  1 
ATOM   1057 N N   . ALA A 1 164 ? 137.001 136.893 135.762 1.00 72.77  ? 164 ALA B N   1 
ATOM   1058 C CA  . ALA A 1 164 ? 138.367 136.834 135.254 1.00 72.77  ? 164 ALA B CA  1 
ATOM   1059 C C   . ALA A 1 164 ? 139.375 136.826 136.394 1.00 72.77  ? 164 ALA B C   1 
ATOM   1060 O O   . ALA A 1 164 ? 140.359 136.082 136.355 1.00 72.77  ? 164 ALA B O   1 
ATOM   1061 C CB  . ALA A 1 164 ? 138.631 138.010 134.313 1.00 72.77  ? 164 ALA B CB  1 
ATOM   1062 N N   . THR A 1 165 ? 139.142 137.644 137.421 1.00 71.41  ? 165 THR B N   1 
ATOM   1063 C CA  . THR A 1 165 ? 140.039 137.651 138.572 1.00 71.41  ? 165 THR B CA  1 
ATOM   1064 C C   . THR A 1 165 ? 140.036 136.305 139.283 1.00 71.41  ? 165 THR B C   1 
ATOM   1065 O O   . THR A 1 165 ? 141.094 135.797 139.669 1.00 71.41  ? 165 THR B O   1 
ATOM   1066 C CB  . THR A 1 165 ? 139.654 138.762 139.546 1.00 71.41  ? 165 THR B CB  1 
ATOM   1067 O OG1 . THR A 1 165 ? 138.324 138.536 140.028 1.00 71.41  ? 165 THR B OG1 1 
ATOM   1068 C CG2 . THR A 1 165 ? 139.736 140.122 138.868 1.00 71.41  ? 165 THR B CG2 1 
ATOM   1069 N N   . LEU A 1 166 ? 138.855 135.709 139.462 1.00 68.70  ? 166 LEU B N   1 
ATOM   1070 C CA  . LEU A 1 166 ? 138.769 134.420 140.143 1.00 68.70  ? 166 LEU B CA  1 
ATOM   1071 C C   . LEU A 1 166 ? 139.463 133.321 139.344 1.00 68.70  ? 166 LEU B C   1 
ATOM   1072 O O   . LEU A 1 166 ? 140.216 132.511 139.904 1.00 68.70  ? 166 LEU B O   1 
ATOM   1073 C CB  . LEU A 1 166 ? 137.306 134.060 140.395 1.00 68.70  ? 166 LEU B CB  1 
ATOM   1074 C CG  . LEU A 1 166 ? 136.633 134.768 141.571 1.00 68.70  ? 166 LEU B CG  1 
ATOM   1075 C CD1 . LEU A 1 166 ? 135.146 134.958 141.310 1.00 68.70  ? 166 LEU B CD1 1 
ATOM   1076 C CD2 . LEU A 1 166 ? 136.863 133.991 142.858 1.00 68.70  ? 166 LEU B CD2 1 
ATOM   1077 N N   . VAL A 1 167 ? 139.225 133.276 138.031 1.00 67.12  ? 167 VAL B N   1 
ATOM   1078 C CA  . VAL A 1 167 ? 139.854 132.234 137.229 1.00 67.12  ? 167 VAL B CA  1 
ATOM   1079 C C   . VAL A 1 167 ? 141.356 132.465 137.132 1.00 67.12  ? 167 VAL B C   1 
ATOM   1080 O O   . VAL A 1 167 ? 142.129 131.505 137.089 1.00 67.12  ? 167 VAL B O   1 
ATOM   1081 C CB  . VAL A 1 167 ? 139.197 132.119 135.838 1.00 67.12  ? 167 VAL B CB  1 
ATOM   1082 C CG1 . VAL A 1 167 ? 137.711 131.803 135.975 1.00 67.12  ? 167 VAL B CG1 1 
ATOM   1083 C CG2 . VAL A 1 167 ? 139.414 133.373 135.011 1.00 67.12  ? 167 VAL B CG2 1 
ATOM   1084 N N   . GLY A 1 168 ? 141.802 133.723 137.117 1.00 59.63  ? 168 GLY B N   1 
ATOM   1085 C CA  . GLY A 1 168 ? 143.229 133.987 137.152 1.00 59.63  ? 168 GLY B CA  1 
ATOM   1086 C C   . GLY A 1 168 ? 143.858 133.569 138.464 1.00 59.63  ? 168 GLY B C   1 
ATOM   1087 O O   . GLY A 1 168 ? 144.978 133.057 138.488 1.00 59.63  ? 168 GLY B O   1 
ATOM   1088 N N   . PHE A 1 169 ? 143.145 133.779 139.572 1.00 58.56  ? 169 PHE B N   1 
ATOM   1089 C CA  . PHE A 1 169 ? 143.614 133.303 140.868 1.00 58.56  ? 169 PHE B CA  1 
ATOM   1090 C C   . PHE A 1 169 ? 143.776 131.790 140.859 1.00 58.56  ? 169 PHE B C   1 
ATOM   1091 O O   . PHE A 1 169 ? 144.813 131.259 141.277 1.00 58.56  ? 169 PHE B O   1 
ATOM   1092 C CB  . PHE A 1 169 ? 142.630 133.732 141.956 1.00 58.56  ? 169 PHE B CB  1 
ATOM   1093 C CG  . PHE A 1 169 ? 143.272 134.039 143.276 1.00 58.56  ? 169 PHE B CG  1 
ATOM   1094 C CD1 . PHE A 1 169 ? 143.889 135.259 143.496 1.00 58.56  ? 169 PHE B CD1 1 
ATOM   1095 C CD2 . PHE A 1 169 ? 143.246 133.113 144.304 1.00 58.56  ? 169 PHE B CD2 1 
ATOM   1096 C CE1 . PHE A 1 169 ? 144.476 135.546 144.713 1.00 58.56  ? 169 PHE B CE1 1 
ATOM   1097 C CE2 . PHE A 1 169 ? 143.831 133.393 145.524 1.00 58.56  ? 169 PHE B CE2 1 
ATOM   1098 C CZ  . PHE A 1 169 ? 144.446 134.611 145.728 1.00 58.56  ? 169 PHE B CZ  1 
ATOM   1099 N N   . THR A 1 170 ? 142.760 131.080 140.361 1.00 58.98  ? 170 THR B N   1 
ATOM   1100 C CA  . THR A 1 170 ? 142.837 129.623 140.298 1.00 58.98  ? 170 THR B CA  1 
ATOM   1101 C C   . THR A 1 170 ? 143.972 129.164 139.390 1.00 58.98  ? 170 THR B C   1 
ATOM   1102 O O   . THR A 1 170 ? 144.717 128.237 139.733 1.00 58.98  ? 170 THR B O   1 
ATOM   1103 C CB  . THR A 1 170 ? 141.508 129.041 139.818 1.00 58.98  ? 170 THR B CB  1 
ATOM   1104 O OG1 . THR A 1 170 ? 141.219 129.529 138.502 1.00 58.98  ? 170 THR B OG1 1 
ATOM   1105 C CG2 . THR A 1 170 ? 140.381 129.424 140.761 1.00 58.98  ? 170 THR B CG2 1 
ATOM   1106 N N   . VAL A 1 171 ? 144.119 129.805 138.228 1.00 64.49  ? 171 VAL B N   1 
ATOM   1107 C CA  . VAL A 1 171 ? 145.146 129.410 137.271 1.00 64.49  ? 171 VAL B CA  1 
ATOM   1108 C C   . VAL A 1 171 ? 146.535 129.666 137.839 1.00 64.49  ? 171 VAL B C   1 
ATOM   1109 O O   . VAL A 1 171 ? 147.433 128.830 137.707 1.00 64.49  ? 171 VAL B O   1 
ATOM   1110 C CB  . VAL A 1 171 ? 144.932 130.139 135.932 1.00 64.49  ? 171 VAL B CB  1 
ATOM   1111 C CG1 . VAL A 1 171 ? 146.204 130.113 135.092 1.00 64.49  ? 171 VAL B CG1 1 
ATOM   1112 C CG2 . VAL A 1 171 ? 143.774 129.511 135.168 1.00 64.49  ? 171 VAL B CG2 1 
ATOM   1113 N N   . GLY A 1 172 ? 146.735 130.816 138.483 1.00 60.49  ? 172 GLY B N   1 
ATOM   1114 C CA  . GLY A 1 172 ? 148.018 131.090 139.104 1.00 60.49  ? 172 GLY B CA  1 
ATOM   1115 C C   . GLY A 1 172 ? 148.341 130.120 140.223 1.00 60.49  ? 172 GLY B C   1 
ATOM   1116 O O   . GLY A 1 172 ? 149.479 129.666 140.352 1.00 60.49  ? 172 GLY B O   1 
ATOM   1117 N N   . SER A 1 173 ? 147.342 129.782 141.042 1.00 57.38  ? 173 SER B N   1 
ATOM   1118 C CA  . SER A 1 173 ? 147.574 128.834 142.126 1.00 57.38  ? 173 SER B CA  1 
ATOM   1119 C C   . SER A 1 173 ? 147.957 127.462 141.585 1.00 57.38  ? 173 SER B C   1 
ATOM   1120 O O   . SER A 1 173 ? 148.923 126.845 142.053 1.00 57.38  ? 173 SER B O   1 
ATOM   1121 C CB  . SER A 1 173 ? 146.331 128.739 143.008 1.00 57.38  ? 173 SER B CB  1 
ATOM   1122 O OG  . SER A 1 173 ? 145.168 128.569 142.220 1.00 57.38  ? 173 SER B OG  1 
ATOM   1123 N N   . VAL A 1 174 ? 147.217 126.967 140.590 1.00 59.23  ? 174 VAL B N   1 
ATOM   1124 C CA  . VAL A 1 174 ? 147.535 125.646 140.056 1.00 59.23  ? 174 VAL B CA  1 
ATOM   1125 C C   . VAL A 1 174 ? 148.856 125.675 139.296 1.00 59.23  ? 174 VAL B C   1 
ATOM   1126 O O   . VAL A 1 174 ? 149.600 124.689 139.302 1.00 59.23  ? 174 VAL B O   1 
ATOM   1127 C CB  . VAL A 1 174 ? 146.382 125.099 139.188 1.00 59.23  ? 174 VAL B CB  1 
ATOM   1128 C CG1 . VAL A 1 174 ? 145.103 125.002 140.006 1.00 59.23  ? 174 VAL B CG1 1 
ATOM   1129 C CG2 . VAL A 1 174 ? 146.166 125.944 137.946 1.00 59.23  ? 174 VAL B CG2 1 
ATOM   1130 N N   . LEU A 1 175 ? 149.181 126.796 138.644 1.00 60.84  ? 175 LEU B N   1 
ATOM   1131 C CA  . LEU A 1 175 ? 150.467 126.919 137.969 1.00 60.84  ? 175 LEU B CA  1 
ATOM   1132 C C   . LEU A 1 175 ? 151.614 126.888 138.966 1.00 60.84  ? 175 LEU B C   1 
ATOM   1133 O O   . LEU A 1 175 ? 152.631 126.229 138.727 1.00 60.84  ? 175 LEU B O   1 
ATOM   1134 C CB  . LEU A 1 175 ? 150.507 128.207 137.149 1.00 60.84  ? 175 LEU B CB  1 
ATOM   1135 C CG  . LEU A 1 175 ? 151.779 128.441 136.331 1.00 60.84  ? 175 LEU B CG  1 
ATOM   1136 C CD1 . LEU A 1 175 ? 151.957 127.351 135.286 1.00 60.84  ? 175 LEU B CD1 1 
ATOM   1137 C CD2 . LEU A 1 175 ? 151.757 129.815 135.682 1.00 60.84  ? 175 LEU B CD2 1 
ATOM   1138 N N   . GLY A 1 176 ? 151.470 127.598 140.086 1.00 57.17  ? 176 GLY B N   1 
ATOM   1139 C CA  . GLY A 1 176 ? 152.483 127.534 141.123 1.00 57.17  ? 176 GLY B CA  1 
ATOM   1140 C C   . GLY A 1 176 ? 152.621 126.140 141.699 1.00 57.17  ? 176 GLY B C   1 
ATOM   1141 O O   . GLY A 1 176 ? 153.734 125.662 141.932 1.00 57.17  ? 176 GLY B O   1 
ATOM   1142 N N   . GLN A 1 177 ? 151.492 125.461 141.916 1.00 55.25  ? 177 GLN B N   1 
ATOM   1143 C CA  . GLN A 1 177 ? 151.537 124.096 142.429 1.00 55.25  ? 177 GLN B CA  1 
ATOM   1144 C C   . GLN A 1 177 ? 152.252 123.163 141.459 1.00 55.25  ? 177 GLN B C   1 
ATOM   1145 O O   . GLN A 1 177 ? 153.077 122.340 141.871 1.00 55.25  ? 177 GLN B O   1 
ATOM   1146 C CB  . GLN A 1 177 ? 150.119 123.596 142.707 1.00 55.25  ? 177 GLN B CB  1 
ATOM   1147 N N   . ILE A 1 178 ? 151.956 123.288 140.164 1.00 55.94  ? 178 ILE B N   1 
ATOM   1148 C CA  . ILE A 1 178 ? 152.585 122.431 139.165 1.00 55.94  ? 178 ILE B CA  1 
ATOM   1149 C C   . ILE A 1 178 ? 154.073 122.734 139.055 1.00 55.94  ? 178 ILE B C   1 
ATOM   1150 O O   . ILE A 1 178 ? 154.902 121.819 138.986 1.00 55.94  ? 178 ILE B O   1 
ATOM   1151 C CB  . ILE A 1 178 ? 151.874 122.585 137.809 1.00 55.94  ? 178 ILE B CB  1 
ATOM   1152 N N   . LEU A 1 179 ? 154.439 124.018 139.040 1.00 51.48  ? 179 LEU B N   1 
ATOM   1153 C CA  . LEU A 1 179 ? 155.838 124.395 138.898 1.00 51.48  ? 179 LEU B CA  1 
ATOM   1154 C C   . LEU A 1 179 ? 156.655 124.091 140.146 1.00 51.48  ? 179 LEU B C   1 
ATOM   1155 O O   . LEU A 1 179 ? 157.876 123.939 140.047 1.00 51.48  ? 179 LEU B O   1 
ATOM   1156 C CB  . LEU A 1 179 ? 155.948 125.881 138.556 1.00 51.48  ? 179 LEU B CB  1 
ATOM   1157 N N   . VAL A 1 180 ? 156.019 123.996 141.310 1.00 53.70  ? 180 VAL B N   1 
ATOM   1158 C CA  . VAL A 1 180 ? 156.740 123.702 142.542 1.00 53.70  ? 180 VAL B CA  1 
ATOM   1159 C C   . VAL A 1 180 ? 156.848 122.203 142.781 1.00 53.70  ? 180 VAL B C   1 
ATOM   1160 O O   . VAL A 1 180 ? 157.929 121.688 143.081 1.00 53.70  ? 180 VAL B O   1 
ATOM   1161 C CB  . VAL A 1 180 ? 156.059 124.414 143.730 1.00 53.70  ? 180 VAL B CB  1 
ATOM   1162 N N   . SER A 1 181 ? 155.740 121.475 142.647 1.00 54.40  ? 181 SER B N   1 
ATOM   1163 C CA  . SER A 1 181 ? 155.703 120.050 142.958 1.00 54.40  ? 181 SER B CA  1 
ATOM   1164 C C   . SER A 1 181 ? 155.814 119.167 141.721 1.00 54.40  ? 181 SER B C   1 
ATOM   1165 O O   . SER A 1 181 ? 156.694 118.304 141.656 1.00 54.40  ? 181 SER B O   1 
ATOM   1166 C CB  . SER A 1 181 ? 154.415 119.717 143.720 1.00 54.40  ? 181 SER B CB  1 
ATOM   1167 N N   . VAL A 1 182 ? 154.927 119.358 140.742 1.00 52.69  ? 182 VAL B N   1 
ATOM   1168 C CA  . VAL A 1 182 ? 154.927 118.503 139.558 1.00 52.69  ? 182 VAL B CA  1 
ATOM   1169 C C   . VAL A 1 182 ? 156.203 118.707 138.750 1.00 52.69  ? 182 VAL B C   1 
ATOM   1170 O O   . VAL A 1 182 ? 156.838 117.743 138.308 1.00 52.69  ? 182 VAL B O   1 
ATOM   1171 C CB  . VAL A 1 182 ? 153.671 118.766 138.708 1.00 52.69  ? 182 VAL B CB  1 
ATOM   1172 N N   . ALA A 1 183 ? 156.598 119.964 138.547 1.00 56.87  ? 183 ALA B N   1 
ATOM   1173 C CA  . ALA A 1 183 ? 157.807 120.260 137.791 1.00 56.87  ? 183 ALA B CA  1 
ATOM   1174 C C   . ALA A 1 183 ? 159.062 120.236 138.651 1.00 56.87  ? 183 ALA B C   1 
ATOM   1175 O O   . ALA A 1 183 ? 160.159 120.046 138.115 1.00 56.87  ? 183 ALA B O   1 
ATOM   1176 C CB  . ALA A 1 183 ? 157.684 121.623 137.106 1.00 56.87  ? 183 ALA B CB  1 
ATOM   1177 N N   . GLY A 1 184 ? 158.927 120.420 139.961 1.00 54.07  ? 184 GLY B N   1 
ATOM   1178 C CA  . GLY A 1 184 ? 160.092 120.471 140.825 1.00 54.07  ? 184 GLY B CA  1 
ATOM   1179 C C   . GLY A 1 184 ? 160.999 121.647 140.554 1.00 54.07  ? 184 GLY B C   1 
ATOM   1180 O O   . GLY A 1 184 ? 162.221 121.528 140.696 1.00 54.07  ? 184 GLY B O   1 
ATOM   1181 N N   . TRP A 1 185 ? 160.434 122.784 140.162 1.00 53.34  ? 185 TRP B N   1 
ATOM   1182 C CA  . TRP A 1 185 ? 161.202 123.996 139.917 1.00 53.34  ? 185 TRP B CA  1 
ATOM   1183 C C   . TRP A 1 185 ? 161.209 124.857 141.172 1.00 53.34  ? 185 TRP B C   1 
ATOM   1184 O O   . TRP A 1 185 ? 160.189 124.985 141.857 1.00 53.34  ? 185 TRP B O   1 
ATOM   1185 C CB  . TRP A 1 185 ? 160.625 124.785 138.739 1.00 53.34  ? 185 TRP B CB  1 
ATOM   1186 N N   . SER A 1 186 ? 162.365 125.443 141.470 1.00 55.41  ? 186 SER B N   1 
ATOM   1187 C CA  . SER A 1 186 ? 162.512 126.249 142.670 1.00 55.41  ? 186 SER B CA  1 
ATOM   1188 C C   . SER A 1 186 ? 161.721 127.550 142.542 1.00 55.41  ? 186 SER B C   1 
ATOM   1189 O O   . SER A 1 186 ? 161.281 127.947 141.460 1.00 55.41  ? 186 SER B O   1 
ATOM   1190 C CB  . SER A 1 186 ? 163.986 126.545 142.940 1.00 55.41  ? 186 SER B CB  1 
ATOM   1191 N N   . LEU A 1 187 ? 161.546 128.220 143.681 1.00 57.06  ? 187 LEU B N   1 
ATOM   1192 C CA  . LEU A 1 187 ? 160.758 129.443 143.734 1.00 57.06  ? 187 LEU B CA  1 
ATOM   1193 C C   . LEU A 1 187 ? 161.457 130.627 143.077 1.00 57.06  ? 187 LEU B C   1 
ATOM   1194 O O   . LEU A 1 187 ? 160.814 131.661 142.864 1.00 57.06  ? 187 LEU B O   1 
ATOM   1195 C CB  . LEU A 1 187 ? 160.424 129.770 145.192 1.00 57.06  ? 187 LEU B CB  1 
ATOM   1196 C CG  . LEU A 1 187 ? 159.286 130.749 145.481 1.00 57.06  ? 187 LEU B CG  1 
ATOM   1197 C CD1 . LEU A 1 187 ? 157.988 130.235 144.897 1.00 57.06  ? 187 LEU B CD1 1 
ATOM   1198 C CD2 . LEU A 1 187 ? 159.145 130.952 146.972 1.00 57.06  ? 187 LEU B CD2 1 
ATOM   1199 N N   . PHE A 1 188 ? 162.747 130.507 142.756 1.00 61.67  ? 188 PHE B N   1 
ATOM   1200 C CA  . PHE A 1 188 ? 163.471 131.616 142.144 1.00 61.67  ? 188 PHE B CA  1 
ATOM   1201 C C   . PHE A 1 188 ? 162.904 131.945 140.766 1.00 61.67  ? 188 PHE B C   1 
ATOM   1202 O O   . PHE A 1 188 ? 162.507 133.083 140.493 1.00 61.67  ? 188 PHE B O   1 
ATOM   1203 C CB  . PHE A 1 188 ? 164.959 131.267 142.055 1.00 61.67  ? 188 PHE B CB  1 
ATOM   1204 C CG  . PHE A 1 188 ? 165.852 132.449 141.808 1.00 61.67  ? 188 PHE B CG  1 
ATOM   1205 C CD1 . PHE A 1 188 ? 166.240 133.269 142.856 1.00 61.67  ? 188 PHE B CD1 1 
ATOM   1206 C CD2 . PHE A 1 188 ? 166.312 132.734 140.534 1.00 61.67  ? 188 PHE B CD2 1 
ATOM   1207 C CE1 . PHE A 1 188 ? 167.067 134.352 142.636 1.00 61.67  ? 188 PHE B CE1 1 
ATOM   1208 C CE2 . PHE A 1 188 ? 167.138 133.817 140.308 1.00 61.67  ? 188 PHE B CE2 1 
ATOM   1209 C CZ  . PHE A 1 188 ? 167.516 134.626 141.361 1.00 61.67  ? 188 PHE B CZ  1 
ATOM   1210 N N   . SER A 1 189 ? 162.814 130.941 139.891 1.00 64.60  ? 189 SER B N   1 
ATOM   1211 C CA  . SER A 1 189 ? 162.202 131.172 138.588 1.00 64.60  ? 189 SER B CA  1 
ATOM   1212 C C   . SER A 1 189 ? 160.733 131.542 138.730 1.00 64.60  ? 189 SER B C   1 
ATOM   1213 O O   . SER A 1 189 ? 160.195 132.295 137.909 1.00 64.60  ? 189 SER B O   1 
ATOM   1214 C CB  . SER A 1 189 ? 162.361 129.934 137.707 1.00 64.60  ? 189 SER B CB  1 
ATOM   1215 O OG  . SER A 1 189 ? 163.694 129.454 137.741 1.00 64.60  ? 189 SER B OG  1 
ATOM   1216 N N   . LEU A 1 190 ? 160.084 131.058 139.789 1.00 59.30  ? 190 LEU B N   1 
ATOM   1217 C CA  . LEU A 1 190 ? 158.657 131.299 139.960 1.00 59.30  ? 190 LEU B CA  1 
ATOM   1218 C C   . LEU A 1 190 ? 158.384 132.763 140.296 1.00 59.30  ? 190 LEU B C   1 
ATOM   1219 O O   . LEU A 1 190 ? 157.501 133.391 139.700 1.00 59.30  ? 190 LEU B O   1 
ATOM   1220 C CB  . LEU A 1 190 ? 158.105 130.362 141.036 1.00 59.30  ? 190 LEU B CB  1 
ATOM   1221 C CG  . LEU A 1 190 ? 156.590 130.200 141.175 1.00 59.30  ? 190 LEU B CG  1 
ATOM   1222 C CD1 . LEU A 1 190 ? 156.273 128.816 141.721 1.00 59.30  ? 190 LEU B CD1 1 
ATOM   1223 C CD2 . LEU A 1 190 ? 155.990 131.261 142.069 1.00 59.30  ? 190 LEU B CD2 1 
ATOM   1224 N N   . ASN A 1 191 ? 159.136 133.342 141.233 1.00 53.25  ? 191 ASN B N   1 
ATOM   1225 C CA  . ASN A 1 191 ? 158.899 134.756 141.492 1.00 53.25  ? 191 ASN B CA  1 
ATOM   1226 C C   . ASN A 1 191 ? 159.517 135.645 140.417 1.00 53.25  ? 191 ASN B C   1 
ATOM   1227 O O   . ASN A 1 191 ? 159.047 136.774 140.230 1.00 53.25  ? 191 ASN B O   1 
ATOM   1228 C CB  . ASN A 1 191 ? 159.366 135.153 142.903 1.00 53.25  ? 191 ASN B CB  1 
ATOM   1229 C CG  . ASN A 1 191 ? 160.859 135.012 143.117 1.00 53.25  ? 191 ASN B CG  1 
ATOM   1230 O OD1 . ASN A 1 191 ? 161.613 134.736 142.199 1.00 53.25  ? 191 ASN B OD1 1 
ATOM   1231 N ND2 . ASN A 1 191 ? 161.288 135.200 144.358 1.00 53.25  ? 191 ASN B ND2 1 
ATOM   1232 N N   . VAL A 1 192 ? 160.505 135.147 139.662 1.00 54.18  ? 192 VAL B N   1 
ATOM   1233 C CA  . VAL A 1 192 ? 160.938 135.870 138.465 1.00 54.18  ? 192 VAL B CA  1 
ATOM   1234 C C   . VAL A 1 192 ? 159.786 135.998 137.474 1.00 54.18  ? 192 VAL B C   1 
ATOM   1235 O O   . VAL A 1 192 ? 159.521 137.083 136.940 1.00 54.18  ? 192 VAL B O   1 
ATOM   1236 C CB  . VAL A 1 192 ? 162.159 135.186 137.823 1.00 54.18  ? 192 VAL B CB  1 
ATOM   1237 C CG1 . VAL A 1 192 ? 162.431 135.783 136.456 1.00 54.18  ? 192 VAL B CG1 1 
ATOM   1238 C CG2 . VAL A 1 192 ? 163.387 135.381 138.692 1.00 54.18  ? 192 VAL B CG2 1 
ATOM   1239 N N   . ILE A 1 193 ? 159.074 134.897 137.220 1.00 55.99  ? 193 ILE B N   1 
ATOM   1240 C CA  . ILE A 1 193 ? 157.971 134.980 136.268 1.00 55.99  ? 193 ILE B CA  1 
ATOM   1241 C C   . ILE A 1 193 ? 156.797 135.741 136.876 1.00 55.99  ? 193 ILE B C   1 
ATOM   1242 O O   . ILE A 1 193 ? 156.002 136.342 136.148 1.00 55.99  ? 193 ILE B O   1 
ATOM   1243 C CB  . ILE A 1 193 ? 157.557 133.582 135.762 1.00 55.99  ? 193 ILE B CB  1 
ATOM   1244 C CG1 . ILE A 1 193 ? 156.770 133.704 134.455 1.00 55.99  ? 193 ILE B CG1 1 
ATOM   1245 C CG2 . ILE A 1 193 ? 156.698 132.858 136.771 1.00 55.99  ? 193 ILE B CG2 1 
ATOM   1246 C CD1 . ILE A 1 193 ? 157.589 134.223 133.290 1.00 55.99  ? 193 ILE B CD1 1 
ATOM   1247 N N   . SER A 1 194 ? 156.682 135.763 138.207 1.00 53.35  ? 194 SER B N   1 
ATOM   1248 C CA  . SER A 1 194 ? 155.679 136.615 138.845 1.00 53.35  ? 194 SER B CA  1 
ATOM   1249 C C   . SER A 1 194 ? 155.959 138.090 138.571 1.00 53.35  ? 194 SER B C   1 
ATOM   1250 O O   . SER A 1 194 ? 155.054 138.857 138.211 1.00 53.35  ? 194 SER B O   1 
ATOM   1251 C CB  . SER A 1 194 ? 155.643 136.345 140.349 1.00 53.35  ? 194 SER B CB  1 
ATOM   1252 O OG  . SER A 1 194 ? 155.533 134.959 140.617 1.00 53.35  ? 194 SER B OG  1 
ATOM   1253 N N   . LEU A 1 195 ? 157.219 138.503 138.738 1.00 54.59  ? 195 LEU B N   1 
ATOM   1254 C CA  . LEU A 1 195 ? 157.593 139.879 138.427 1.00 54.59  ? 195 LEU B CA  1 
ATOM   1255 C C   . LEU A 1 195 ? 157.389 140.180 136.949 1.00 54.59  ? 195 LEU B C   1 
ATOM   1256 O O   . LEU A 1 195 ? 156.914 141.264 136.585 1.00 54.59  ? 195 LEU B O   1 
ATOM   1257 C CB  . LEU A 1 195 ? 159.045 140.138 138.827 1.00 54.59  ? 195 LEU B CB  1 
ATOM   1258 C CG  . LEU A 1 195 ? 159.681 141.385 138.207 1.00 54.59  ? 195 LEU B CG  1 
ATOM   1259 C CD1 . LEU A 1 195 ? 159.127 142.646 138.842 1.00 54.59  ? 195 LEU B CD1 1 
ATOM   1260 C CD2 . LEU A 1 195 ? 161.192 141.341 138.326 1.00 54.59  ? 195 LEU B CD2 1 
ATOM   1261 N N   . THR A 1 196 ? 157.744 139.233 136.081 1.00 55.37  ? 196 THR B N   1 
ATOM   1262 C CA  . THR A 1 196 ? 157.525 139.429 134.653 1.00 55.37  ? 196 THR B CA  1 
ATOM   1263 C C   . THR A 1 196 ? 156.044 139.611 134.351 1.00 55.37  ? 196 THR B C   1 
ATOM   1264 O O   . THR A 1 196 ? 155.666 140.452 133.527 1.00 55.37  ? 196 THR B O   1 
ATOM   1265 C CB  . THR A 1 196 ? 158.094 138.247 133.867 1.00 55.37  ? 196 THR B CB  1 
ATOM   1266 O OG1 . THR A 1 196 ? 159.394 137.919 134.372 1.00 55.37  ? 196 THR B OG1 1 
ATOM   1267 C CG2 . THR A 1 196 ? 158.203 138.592 132.390 1.00 55.37  ? 196 THR B CG2 1 
ATOM   1268 N N   . CYS A 1 197 ? 155.189 138.838 135.022 1.00 58.86  ? 197 CYS B N   1 
ATOM   1269 C CA  . CYS A 1 197 ? 153.754 138.933 134.791 1.00 58.86  ? 197 CYS B CA  1 
ATOM   1270 C C   . CYS A 1 197 ? 153.204 140.277 135.252 1.00 58.86  ? 197 CYS B C   1 
ATOM   1271 O O   . CYS A 1 197 ? 152.369 140.877 134.565 1.00 58.86  ? 197 CYS B O   1 
ATOM   1272 C CB  . CYS A 1 197 ? 153.040 137.782 135.496 1.00 58.86  ? 197 CYS B CB  1 
ATOM   1273 S SG  . CYS A 1 197 ? 151.281 137.678 135.140 1.00 58.86  ? 197 CYS B SG  1 
ATOM   1274 N N   . VAL A 1 198 ? 153.658 140.775 136.407 1.00 56.08  ? 198 VAL B N   1 
ATOM   1275 C CA  . VAL A 1 198 ? 153.158 142.079 136.848 1.00 56.08  ? 198 VAL B CA  1 
ATOM   1276 C C   . VAL A 1 198 ? 153.686 143.196 135.949 1.00 56.08  ? 198 VAL B C   1 
ATOM   1277 O O   . VAL A 1 198 ? 152.986 144.190 135.709 1.00 56.08  ? 198 VAL B O   1 
ATOM   1278 C CB  . VAL A 1 198 ? 153.471 142.336 138.337 1.00 56.08  ? 198 VAL B CB  1 
ATOM   1279 C CG1 . VAL A 1 198 ? 153.023 141.155 139.184 1.00 56.08  ? 198 VAL B CG1 1 
ATOM   1280 C CG2 . VAL A 1 198 ? 154.938 142.647 138.566 1.00 56.08  ? 198 VAL B CG2 1 
ATOM   1281 N N   . SER A 1 199 ? 154.908 143.056 135.424 1.00 56.49  ? 199 SER B N   1 
ATOM   1282 C CA  . SER A 1 199 ? 155.414 144.041 134.471 1.00 56.49  ? 199 SER B CA  1 
ATOM   1283 C C   . SER A 1 199 ? 154.597 144.035 133.186 1.00 56.49  ? 199 SER B C   1 
ATOM   1284 O O   . SER A 1 199 ? 154.296 145.098 132.628 1.00 56.49  ? 199 SER B O   1 
ATOM   1285 C CB  . SER A 1 199 ? 156.887 143.777 134.166 1.00 56.49  ? 199 SER B CB  1 
ATOM   1286 O OG  . SER A 1 199 ? 157.356 144.637 133.143 1.00 56.49  ? 199 SER B OG  1 
ATOM   1287 N N   . VAL A 1 200 ? 154.237 142.845 132.699 1.00 53.78  ? 200 VAL B N   1 
ATOM   1288 C CA  . VAL A 1 200 ? 153.378 142.750 131.522 1.00 53.78  ? 200 VAL B CA  1 
ATOM   1289 C C   . VAL A 1 200 ? 152.021 143.374 131.813 1.00 53.78  ? 200 VAL B C   1 
ATOM   1290 O O   . VAL A 1 200 ? 151.435 144.052 130.960 1.00 53.78  ? 200 VAL B O   1 
ATOM   1291 C CB  . VAL A 1 200 ? 153.249 141.283 131.070 1.00 53.78  ? 200 VAL B CB  1 
ATOM   1292 C CG1 . VAL A 1 200 ? 152.134 141.131 130.049 1.00 53.78  ? 200 VAL B CG1 1 
ATOM   1293 C CG2 . VAL A 1 200 ? 154.563 140.788 130.493 1.00 53.78  ? 200 VAL B CG2 1 
ATOM   1294 N N   . ALA A 1 201 ? 151.508 143.167 133.027 1.00 52.08  ? 201 ALA B N   1 
ATOM   1295 C CA  . ALA A 1 201 ? 150.242 143.778 133.413 1.00 52.08  ? 201 ALA B CA  1 
ATOM   1296 C C   . ALA A 1 201 ? 150.326 145.298 133.372 1.00 52.08  ? 201 ALA B C   1 
ATOM   1297 O O   . ALA A 1 201 ? 149.420 145.962 132.857 1.00 52.08  ? 201 ALA B O   1 
ATOM   1298 C CB  . ALA A 1 201 ? 149.836 143.302 134.807 1.00 52.08  ? 201 ALA B CB  1 
ATOM   1299 N N   . PHE A 1 202 ? 151.408 145.867 133.909 1.00 53.10  ? 202 PHE B N   1 
ATOM   1300 C CA  . PHE A 1 202 ? 151.573 147.319 133.880 1.00 53.10  ? 202 PHE B CA  1 
ATOM   1301 C C   . PHE A 1 202 ? 151.694 147.836 132.450 1.00 53.10  ? 202 PHE B C   1 
ATOM   1302 O O   . PHE A 1 202 ? 151.088 148.857 132.092 1.00 53.10  ? 202 PHE B O   1 
ATOM   1303 C CB  . PHE A 1 202 ? 152.801 147.722 134.697 1.00 53.10  ? 202 PHE B CB  1 
ATOM   1304 C CG  . PHE A 1 202 ? 153.150 149.181 134.592 1.00 53.10  ? 202 PHE B CG  1 
ATOM   1305 C CD1 . PHE A 1 202 ? 152.517 150.114 135.392 1.00 53.10  ? 202 PHE B CD1 1 
ATOM   1306 C CD2 . PHE A 1 202 ? 154.115 149.618 133.698 1.00 53.10  ? 202 PHE B CD2 1 
ATOM   1307 C CE1 . PHE A 1 202 ? 152.837 151.451 135.304 1.00 53.10  ? 202 PHE B CE1 1 
ATOM   1308 C CE2 . PHE A 1 202 ? 154.434 150.959 133.602 1.00 53.10  ? 202 PHE B CE2 1 
ATOM   1309 C CZ  . PHE A 1 202 ? 153.794 151.876 134.407 1.00 53.10  ? 202 PHE B CZ  1 
ATOM   1310 N N   . ALA A 1 203 ? 152.482 147.143 131.621 1.00 55.38  ? 203 ALA B N   1 
ATOM   1311 C CA  . ALA A 1 203 ? 152.663 147.566 130.236 1.00 55.38  ? 203 ALA B CA  1 
ATOM   1312 C C   . ALA A 1 203 ? 151.346 147.520 129.470 1.00 55.38  ? 203 ALA B C   1 
ATOM   1313 O O   . ALA A 1 203 ? 151.082 148.377 128.618 1.00 55.38  ? 203 ALA B O   1 
ATOM   1314 C CB  . ALA A 1 203 ? 153.718 146.693 129.555 1.00 55.38  ? 203 ALA B CB  1 
ATOM   1315 N N   . VAL A 1 204 ? 150.510 146.521 129.758 1.00 53.49  ? 204 VAL B N   1 
ATOM   1316 C CA  . VAL A 1 204 ? 149.188 146.454 129.145 1.00 53.49  ? 204 VAL B CA  1 
ATOM   1317 C C   . VAL A 1 204 ? 148.314 147.598 129.645 1.00 53.49  ? 204 VAL B C   1 
ATOM   1318 O O   . VAL A 1 204 ? 147.677 148.306 128.856 1.00 53.49  ? 204 VAL B O   1 
ATOM   1319 C CB  . VAL A 1 204 ? 148.544 145.084 129.423 1.00 53.49  ? 204 VAL B CB  1 
ATOM   1320 C CG1 . VAL A 1 204 ? 147.057 145.127 129.135 1.00 53.49  ? 204 VAL B CG1 1 
ATOM   1321 C CG2 . VAL A 1 204 ? 149.222 143.998 128.602 1.00 53.49  ? 204 VAL B CG2 1 
ATOM   1322 N N   . ALA A 1 205 ? 148.291 147.814 130.963 1.00 51.55  ? 205 ALA B N   1 
ATOM   1323 C CA  . ALA A 1 205 ? 147.411 148.816 131.552 1.00 51.55  ? 205 ALA B CA  1 
ATOM   1324 C C   . ALA A 1 205 ? 147.797 150.235 131.171 1.00 51.55  ? 205 ALA B C   1 
ATOM   1325 O O   . ALA A 1 205 ? 146.990 151.152 131.355 1.00 51.55  ? 205 ALA B O   1 
ATOM   1326 C CB  . ALA A 1 205 ? 147.405 148.687 133.073 1.00 51.55  ? 205 ALA B CB  1 
ATOM   1327 N N   . TRP A 1 206 ? 149.017 150.443 130.670 1.00 50.33  ? 206 TRP B N   1 
ATOM   1328 C CA  . TRP A 1 206 ? 149.406 151.786 130.250 1.00 50.33  ? 206 TRP B CA  1 
ATOM   1329 C C   . TRP A 1 206 ? 148.559 152.317 129.097 1.00 50.33  ? 206 TRP B C   1 
ATOM   1330 O O   . TRP A 1 206 ? 148.483 153.537 128.918 1.00 50.33  ? 206 TRP B O   1 
ATOM   1331 C CB  . TRP A 1 206 ? 150.881 151.815 129.848 1.00 50.33  ? 206 TRP B CB  1 
ATOM   1332 C CG  . TRP A 1 206 ? 151.471 153.193 129.872 1.00 50.33  ? 206 TRP B CG  1 
ATOM   1333 C CD1 . TRP A 1 206 ? 152.027 153.825 130.942 1.00 50.33  ? 206 TRP B CD1 1 
ATOM   1334 C CD2 . TRP A 1 206 ? 151.558 154.110 128.775 1.00 50.33  ? 206 TRP B CD2 1 
ATOM   1335 N NE1 . TRP A 1 206 ? 152.458 155.077 130.582 1.00 50.33  ? 206 TRP B NE1 1 
ATOM   1336 C CE2 . TRP A 1 206 ? 152.182 155.276 129.255 1.00 50.33  ? 206 TRP B CE2 1 
ATOM   1337 C CE3 . TRP A 1 206 ? 151.172 154.056 127.432 1.00 50.33  ? 206 TRP B CE3 1 
ATOM   1338 C CZ2 . TRP A 1 206 ? 152.429 156.379 128.442 1.00 50.33  ? 206 TRP B CZ2 1 
ATOM   1339 C CZ3 . TRP A 1 206 ? 151.416 155.152 126.627 1.00 50.33  ? 206 TRP B CZ3 1 
ATOM   1340 C CH2 . TRP A 1 206 ? 152.039 156.297 127.134 1.00 50.33  ? 206 TRP B CH2 1 
ATOM   1341 N N   . PHE A 1 207 ? 147.915 151.444 128.323 1.00 46.03  ? 207 PHE B N   1 
ATOM   1342 C CA  . PHE A 1 207 ? 147.234 151.843 127.091 1.00 46.03  ? 207 PHE B CA  1 
ATOM   1343 C C   . PHE A 1 207 ? 145.718 151.877 127.246 1.00 46.03  ? 207 PHE B C   1 
ATOM   1344 O O   . PHE A 1 207 ? 144.985 151.485 126.336 1.00 46.03  ? 207 PHE B O   1 
ATOM   1345 C CB  . PHE A 1 207 ? 147.637 150.916 125.948 1.00 46.03  ? 207 PHE B CB  1 
ATOM   1346 C CG  . PHE A 1 207 ? 147.529 151.545 124.586 1.00 46.03  ? 207 PHE B CG  1 
ATOM   1347 C CD1 . PHE A 1 207 ? 148.262 152.677 124.273 1.00 46.03  ? 207 PHE B CD1 1 
ATOM   1348 C CD2 . PHE A 1 207 ? 146.708 150.997 123.616 1.00 46.03  ? 207 PHE B CD2 1 
ATOM   1349 C CE1 . PHE A 1 207 ? 148.171 153.257 123.021 1.00 46.03  ? 207 PHE B CE1 1 
ATOM   1350 C CE2 . PHE A 1 207 ? 146.613 151.573 122.361 1.00 46.03  ? 207 PHE B CE2 1 
ATOM   1351 C CZ  . PHE A 1 207 ? 147.347 152.705 122.065 1.00 46.03  ? 207 PHE B CZ  1 
ATOM   1352 N N   . LEU A 1 208 ? 145.220 152.337 128.389 1.00 46.56  ? 208 LEU B N   1 
ATOM   1353 C CA  . LEU A 1 208 ? 143.787 152.441 128.610 1.00 46.56  ? 208 LEU B CA  1 
ATOM   1354 C C   . LEU A 1 208 ? 143.222 153.720 127.994 1.00 46.56  ? 208 LEU B C   1 
ATOM   1355 O O   . LEU A 1 208 ? 143.944 154.699 127.794 1.00 46.56  ? 208 LEU B O   1 
ATOM   1356 C CB  . LEU A 1 208 ? 143.485 152.402 130.105 1.00 46.56  ? 208 LEU B CB  1 
ATOM   1357 C CG  . LEU A 1 208 ? 143.706 151.046 130.774 1.00 46.56  ? 208 LEU B CG  1 
ATOM   1358 C CD1 . LEU A 1 208 ? 143.227 151.076 132.215 1.00 46.56  ? 208 LEU B CD1 1 
ATOM   1359 C CD2 . LEU A 1 208 ? 143.017 149.945 129.989 1.00 46.56  ? 208 LEU B CD2 1 
ATOM   1360 N N   . PRO A 1 209 ? 141.919 153.731 127.674 1.00 47.37  ? 209 PRO B N   1 
ATOM   1361 C CA  . PRO A 1 209 ? 141.303 154.949 127.130 1.00 47.37  ? 209 PRO B CA  1 
ATOM   1362 C C   . PRO A 1 209 ? 141.017 155.992 128.197 1.00 47.37  ? 209 PRO B C   1 
ATOM   1363 O O   . PRO A 1 209 ? 141.391 155.828 129.363 1.00 47.37  ? 209 PRO B O   1 
ATOM   1364 C CB  . PRO A 1 209 ? 140.004 154.434 126.499 1.00 47.37  ? 209 PRO B CB  1 
ATOM   1365 C CG  . PRO A 1 209 ? 139.680 153.218 127.277 1.00 47.37  ? 209 PRO B CG  1 
ATOM   1366 C CD  . PRO A 1 209 ? 140.995 152.586 127.634 1.00 47.37  ? 209 PRO B CD  1 
ATOM   1367 N N   . MET A 1 210 ? 140.347 157.068 127.801 1.00 47.52  ? 210 MET B N   1 
ATOM   1368 C CA  . MET A 1 210 ? 140.113 158.191 128.698 1.00 47.52  ? 210 MET B CA  1 
ATOM   1369 C C   . MET A 1 210 ? 138.927 157.914 129.612 1.00 47.52  ? 210 MET B C   1 
ATOM   1370 O O   . MET A 1 210 ? 137.830 157.636 129.118 1.00 47.52  ? 210 MET B O   1 
ATOM   1371 C CB  . MET A 1 210 ? 139.863 159.464 127.904 1.00 47.52  ? 210 MET B CB  1 
ATOM   1372 C CG  . MET A 1 210 ? 139.728 160.710 128.765 1.00 47.52  ? 210 MET B CG  1 
ATOM   1373 S SD  . MET A 1 210 ? 141.234 161.104 129.673 1.00 47.52  ? 210 MET B SD  1 
ATOM   1374 C CE  . MET A 1 210 ? 142.279 161.697 128.345 1.00 47.52  ? 210 MET B CE  1 
ATOM   1375 N N   . PRO A 1 211 ? 139.097 157.981 130.928 1.00 48.68  ? 211 PRO B N   1 
ATOM   1376 C CA  . PRO A 1 211 ? 137.942 157.929 131.832 1.00 48.68  ? 211 PRO B CA  1 
ATOM   1377 C C   . PRO A 1 211 ? 137.180 159.243 131.815 1.00 48.68  ? 211 PRO B C   1 
ATOM   1378 O O   . PRO A 1 211 ? 137.444 160.128 132.636 1.00 48.68  ? 211 PRO B O   1 
ATOM   1379 C CB  . PRO A 1 211 ? 138.569 157.659 133.207 1.00 48.68  ? 211 PRO B CB  1 
ATOM   1380 C CG  . PRO A 1 211 ? 140.013 157.348 132.947 1.00 48.68  ? 211 PRO B CG  1 
ATOM   1381 C CD  . PRO A 1 211 ? 140.369 158.001 131.661 1.00 48.68  ? 211 PRO B CD  1 
ATOM   1382 N N   . GLN A 1 212 ? 136.251 159.380 130.863 1.00 43.94  ? 212 GLN B N   1 
ATOM   1383 C CA  . GLN A 1 212 ? 135.542 160.642 130.673 1.00 43.94  ? 212 GLN B CA  1 
ATOM   1384 C C   . GLN A 1 212 ? 134.851 161.109 131.948 1.00 43.94  ? 212 GLN B C   1 
ATOM   1385 O O   . GLN A 1 212 ? 134.744 162.317 132.188 1.00 43.94  ? 212 GLN B O   1 
ATOM   1386 C CB  . GLN A 1 212 ? 134.530 160.500 129.536 1.00 43.94  ? 212 GLN B CB  1 
ATOM   1387 C CG  . GLN A 1 212 ? 133.897 161.808 129.104 1.00 43.94  ? 212 GLN B CG  1 
ATOM   1388 C CD  . GLN A 1 212 ? 134.927 162.869 128.782 1.00 43.94  ? 212 GLN B CD  1 
ATOM   1389 O OE1 . GLN A 1 212 ? 135.150 163.790 129.567 1.00 43.94  ? 212 GLN B OE1 1 
ATOM   1390 N NE2 . GLN A 1 212 ? 135.564 162.745 127.625 1.00 43.94  ? 212 GLN B NE2 1 
ATOM   1391 N N   . LYS A 1 213 ? 134.391 160.180 132.779 1.00 46.10  ? 213 LYS B N   1 
ATOM   1392 C CA  . LYS A 1 213 ? 133.782 160.538 134.054 1.00 46.10  ? 213 LYS B CA  1 
ATOM   1393 C C   . LYS A 1 213 ? 134.847 160.827 135.106 1.00 46.10  ? 213 LYS B C   1 
ATOM   1394 O O   . LYS A 1 213 ? 135.808 161.551 134.847 1.00 46.10  ? 213 LYS B O   1 
ATOM   1395 C CB  . LYS A 1 213 ? 132.855 159.423 134.538 1.00 46.10  ? 213 LYS B CB  1 
ATOM   1396 N N   . VAL A 1 278 ? 130.712 168.404 152.034 1.00 77.29  ? 278 VAL B N   1 
ATOM   1397 C CA  . VAL A 1 278 ? 131.230 167.115 152.474 1.00 77.29  ? 278 VAL B CA  1 
ATOM   1398 C C   . VAL A 1 278 ? 131.413 167.097 153.989 1.00 77.29  ? 278 VAL B C   1 
ATOM   1399 O O   . VAL A 1 278 ? 131.743 166.065 154.572 1.00 77.29  ? 278 VAL B O   1 
ATOM   1400 C CB  . VAL A 1 278 ? 132.550 166.775 151.763 1.00 77.29  ? 278 VAL B CB  1 
ATOM   1401 N N   . LEU A 1 279 ? 131.198 168.248 154.627 1.00 74.30  ? 279 LEU B N   1 
ATOM   1402 C CA  . LEU A 1 279 ? 131.292 168.319 156.080 1.00 74.30  ? 279 LEU B CA  1 
ATOM   1403 C C   . LEU A 1 279 ? 130.081 167.664 156.734 1.00 74.30  ? 279 LEU B C   1 
ATOM   1404 O O   . LEU A 1 279 ? 130.216 166.698 157.493 1.00 74.30  ? 279 LEU B O   1 
ATOM   1405 C CB  . LEU A 1 279 ? 131.428 169.776 156.530 1.00 74.30  ? 279 LEU B CB  1 
ATOM   1406 N N   . LYS A 1 280 ? 128.886 168.178 156.444 1.00 70.42  ? 280 LYS B N   1 
ATOM   1407 C CA  . LYS A 1 280 ? 127.647 167.612 156.964 1.00 70.42  ? 280 LYS B CA  1 
ATOM   1408 C C   . LYS A 1 280 ? 126.892 166.777 155.941 1.00 70.42  ? 280 LYS B C   1 
ATOM   1409 O O   . LYS A 1 280 ? 126.166 165.856 156.328 1.00 70.42  ? 280 LYS B O   1 
ATOM   1410 C CB  . LYS A 1 280 ? 126.728 168.727 157.476 1.00 70.42  ? 280 LYS B CB  1 
ATOM   1411 N N   . VAL A 1 281 ? 127.033 167.081 154.648 1.00 64.53  ? 281 VAL B N   1 
ATOM   1412 C CA  . VAL A 1 281 ? 126.354 166.297 153.620 1.00 64.53  ? 281 VAL B CA  1 
ATOM   1413 C C   . VAL A 1 281 ? 126.944 164.894 153.536 1.00 64.53  ? 281 VAL B C   1 
ATOM   1414 O O   . VAL A 1 281 ? 126.216 163.895 153.541 1.00 64.53  ? 281 VAL B O   1 
ATOM   1415 C CB  . VAL A 1 281 ? 126.423 167.020 152.263 1.00 64.53  ? 281 VAL B CB  1 
ATOM   1416 N N   . LEU A 1 282 ? 128.274 164.797 153.459 1.00 66.62  ? 282 LEU B N   1 
ATOM   1417 C CA  . LEU A 1 282 ? 128.911 163.485 153.384 1.00 66.62  ? 282 LEU B CA  1 
ATOM   1418 C C   . LEU A 1 282 ? 128.791 162.739 154.705 1.00 66.62  ? 282 LEU B C   1 
ATOM   1419 O O   . LEU A 1 282 ? 128.685 161.508 154.722 1.00 66.62  ? 282 LEU B O   1 
ATOM   1420 C CB  . LEU A 1 282 ? 130.377 163.629 152.980 1.00 66.62  ? 282 LEU B CB  1 
ATOM   1421 N N   . TRP A 1 283 ? 128.824 163.467 155.824 1.00 68.11  ? 283 TRP B N   1 
ATOM   1422 C CA  . TRP A 1 283 ? 128.592 162.838 157.119 1.00 68.11  ? 283 TRP B CA  1 
ATOM   1423 C C   . TRP A 1 283 ? 127.183 162.266 157.202 1.00 68.11  ? 283 TRP B C   1 
ATOM   1424 O O   . TRP A 1 283 ? 126.982 161.161 157.719 1.00 68.11  ? 283 TRP B O   1 
ATOM   1425 C CB  . TRP A 1 283 ? 128.831 163.846 158.243 1.00 68.11  ? 283 TRP B CB  1 
ATOM   1426 N N   . ASN A 1 284 ? 126.193 163.007 156.698 1.00 71.98  ? 284 ASN B N   1 
ATOM   1427 C CA  . ASN A 1 284 ? 124.833 162.491 156.633 1.00 71.98  ? 284 ASN B CA  1 
ATOM   1428 C C   . ASN A 1 284 ? 124.654 161.486 155.504 1.00 71.98  ? 284 ASN B C   1 
ATOM   1429 O O   . ASN A 1 284 ? 123.677 160.730 155.514 1.00 71.98  ? 284 ASN B O   1 
ATOM   1430 C CB  . ASN A 1 284 ? 123.837 163.640 156.466 1.00 71.98  ? 284 ASN B CB  1 
ATOM   1431 N N   . ASP A 1 285 ? 125.565 161.473 154.528 1.00 72.56  ? 285 ASP B N   1 
ATOM   1432 C CA  . ASP A 1 285 ? 125.467 160.508 153.437 1.00 72.56  ? 285 ASP B CA  1 
ATOM   1433 C C   . ASP A 1 285 ? 125.617 159.081 153.947 1.00 72.56  ? 285 ASP B C   1 
ATOM   1434 O O   . ASP A 1 285 ? 124.872 158.185 153.532 1.00 72.56  ? 285 ASP B O   1 
ATOM   1435 C CB  . ASP A 1 285 ? 126.520 160.813 152.373 1.00 72.56  ? 285 ASP B CB  1 
ATOM   1436 N N   . PHE A 1 286 ? 126.574 158.848 154.846 1.00 72.06  ? 286 PHE B N   1 
ATOM   1437 C CA  . PHE A 1 286 ? 126.723 157.528 155.446 1.00 72.06  ? 286 PHE B CA  1 
ATOM   1438 C C   . PHE A 1 286 ? 125.841 157.358 156.677 1.00 72.06  ? 286 PHE B C   1 
ATOM   1439 O O   . PHE A 1 286 ? 125.477 156.227 157.019 1.00 72.06  ? 286 PHE B O   1 
ATOM   1440 C CB  . PHE A 1 286 ? 128.187 157.276 155.809 1.00 72.06  ? 286 PHE B CB  1 
ATOM   1441 N N   . LEU A 1 287 ? 125.498 158.458 157.353 1.00 71.01  ? 287 LEU B N   1 
ATOM   1442 C CA  . LEU A 1 287 ? 124.637 158.374 158.529 1.00 71.01  ? 287 LEU B CA  1 
ATOM   1443 C C   . LEU A 1 287 ? 123.238 157.895 158.162 1.00 71.01  ? 287 LEU B C   1 
ATOM   1444 O O   . LEU A 1 287 ? 122.630 157.112 158.902 1.00 71.01  ? 287 LEU B O   1 
ATOM   1445 C CB  . LEU A 1 287 ? 124.571 159.729 159.232 1.00 71.01  ? 287 LEU B CB  1 
ATOM   1446 N N   . MET A 1 288 ? 122.709 158.358 157.026 1.00 70.43  ? 288 MET B N   1 
ATOM   1447 C CA  . MET A 1 288 ? 121.391 157.920 156.580 1.00 70.43  ? 288 MET B CA  1 
ATOM   1448 C C   . MET A 1 288 ? 121.359 156.432 156.263 1.00 70.43  ? 288 MET B C   1 
ATOM   1449 O O   . MET A 1 288 ? 120.283 155.825 156.292 1.00 70.43  ? 288 MET B O   1 
ATOM   1450 C CB  . MET A 1 288 ? 120.957 158.724 155.354 1.00 70.43  ? 288 MET B CB  1 
ATOM   1451 N N   . CYS A 1 289 ? 122.511 155.833 155.972 1.00 66.76  ? 289 CYS B N   1 
ATOM   1452 C CA  . CYS A 1 289 ? 122.622 154.395 155.770 1.00 66.76  ? 289 CYS B CA  1 
ATOM   1453 C C   . CYS A 1 289 ? 122.572 153.611 157.076 1.00 66.76  ? 289 CYS B C   1 
ATOM   1454 O O   . CYS A 1 289 ? 122.890 152.417 157.078 1.00 66.76  ? 289 CYS B O   1 
ATOM   1455 C CB  . CYS A 1 289 ? 123.915 154.068 155.019 1.00 66.76  ? 289 CYS B CB  1 
ATOM   1456 N N   . TYR A 1 290 ? 122.202 154.258 158.182 1.00 63.17  ? 290 TYR B N   1 
ATOM   1457 C CA  . TYR A 1 290 ? 122.041 153.573 159.455 1.00 63.17  ? 290 TYR B CA  1 
ATOM   1458 C C   . TYR A 1 290 ? 120.801 154.008 160.222 1.00 63.17  ? 290 TYR B C   1 
ATOM   1459 O O   . TYR A 1 290 ? 120.523 153.433 161.278 1.00 63.17  ? 290 TYR B O   1 
ATOM   1460 C CB  . TYR A 1 290 ? 123.281 153.787 160.335 1.00 63.17  ? 290 TYR B CB  1 
ATOM   1461 N N   . SER A 1 291 ? 120.048 154.988 159.733 1.00 61.82  ? 291 SER B N   1 
ATOM   1462 C CA  . SER A 1 291 ? 118.845 155.460 160.420 1.00 61.82  ? 291 SER B CA  1 
ATOM   1463 C C   . SER A 1 291 ? 117.600 154.724 159.937 1.00 61.82  ? 291 SER B C   1 
ATOM   1464 O O   . SER A 1 291 ? 116.603 155.328 159.540 1.00 61.82  ? 291 SER B O   1 
ATOM   1465 C CB  . SER A 1 291 ? 118.698 156.966 160.237 1.00 61.82  ? 291 SER B CB  1 
ATOM   1466 N N   . SER A 1 292 ? 117.663 153.395 159.968 1.00 66.19  ? 292 SER B N   1 
ATOM   1467 C CA  . SER A 1 292 ? 116.532 152.546 159.619 1.00 66.19  ? 292 SER B CA  1 
ATOM   1468 C C   . SER A 1 292 ? 116.787 151.162 160.196 1.00 66.19  ? 292 SER B C   1 
ATOM   1469 O O   . SER A 1 292 ? 117.906 150.833 160.598 1.00 66.19  ? 292 SER B O   1 
ATOM   1470 C CB  . SER A 1 292 ? 116.317 152.483 158.104 1.00 66.19  ? 292 SER B CB  1 
ATOM   1471 N N   . ARG A 1 293 ? 115.727 150.354 160.238 1.00 65.11  ? 293 ARG B N   1 
ATOM   1472 C CA  . ARG A 1 293 ? 115.847 149.005 160.788 1.00 65.11  ? 293 ARG B CA  1 
ATOM   1473 C C   . ARG A 1 293 ? 116.843 148.152 160.019 1.00 65.11  ? 293 ARG B C   1 
ATOM   1474 O O   . ARG A 1 293 ? 117.689 147.500 160.656 1.00 65.11  ? 293 ARG B O   1 
ATOM   1475 C CB  . ARG A 1 293 ? 114.467 148.342 160.830 1.00 65.11  ? 293 ARG B CB  1 
ATOM   1476 N N   . PRO A 1 294 ? 116.816 148.105 158.690 1.00 63.02  ? 294 PRO B N   1 
ATOM   1477 C CA  . PRO A 1 294 ? 117.781 147.263 157.971 1.00 63.02  ? 294 PRO B CA  1 
ATOM   1478 C C   . PRO A 1 294 ? 119.008 148.039 157.523 1.00 63.02  ? 294 PRO B C   1 
ATOM   1479 O O   . PRO A 1 294 ? 119.966 147.453 157.007 1.00 63.02  ? 294 PRO B O   1 
ATOM   1480 C CB  . PRO A 1 294 ? 116.972 146.748 156.775 1.00 63.02  ? 294 PRO B CB  1 
ATOM   1481 N N   . LEU A 1 295 ? 118.985 149.361 157.705 1.00 63.67  ? 295 LEU B N   1 
ATOM   1482 C CA  . LEU A 1 295 ? 120.103 150.187 157.261 1.00 63.67  ? 295 LEU B CA  1 
ATOM   1483 C C   . LEU A 1 295 ? 121.358 149.905 158.076 1.00 63.67  ? 295 LEU B C   1 
ATOM   1484 O O   . LEU A 1 295 ? 122.430 149.646 157.517 1.00 63.67  ? 295 LEU B O   1 
ATOM   1485 C CB  . LEU A 1 295 ? 119.725 151.666 157.345 1.00 63.67  ? 295 LEU B CB  1 
ATOM   1486 N N   . LEU A 1 296 ? 121.243 149.941 159.404 1.00 62.11  ? 296 LEU B N   1 
ATOM   1487 C CA  . LEU A 1 296 ? 122.392 149.660 160.256 1.00 62.11  ? 296 LEU B CA  1 
ATOM   1488 C C   . LEU A 1 296 ? 122.694 148.170 160.330 1.00 62.11  ? 296 LEU B C   1 
ATOM   1489 O O   . LEU A 1 296 ? 123.843 147.784 160.572 1.00 62.11  ? 296 LEU B O   1 
ATOM   1490 C CB  . LEU A 1 296 ? 122.151 150.219 161.660 1.00 62.11  ? 296 LEU B CB  1 
ATOM   1491 C CG  . LEU A 1 296 ? 123.313 150.189 162.659 1.00 62.11  ? 296 LEU B CG  1 
ATOM   1492 C CD1 . LEU A 1 296 ? 124.572 150.789 162.050 1.00 62.11  ? 296 LEU B CD1 1 
ATOM   1493 C CD2 . LEU A 1 296 ? 122.942 150.903 163.954 1.00 62.11  ? 296 LEU B CD2 1 
ATOM   1494 N N   . CYS A 1 297 ? 121.690 147.327 160.115 1.00 55.15  ? 297 CYS B N   1 
ATOM   1495 C CA  . CYS A 1 297 ? 121.858 145.898 160.313 1.00 55.15  ? 297 CYS B CA  1 
ATOM   1496 C C   . CYS A 1 297 ? 122.694 145.278 159.193 1.00 55.15  ? 297 CYS B C   1 
ATOM   1497 O O   . CYS A 1 297 ? 122.780 145.795 158.076 1.00 55.15  ? 297 CYS B O   1 
ATOM   1498 C CB  . CYS A 1 297 ? 120.496 145.213 160.411 1.00 55.15  ? 297 CYS B CB  1 
ATOM   1499 S SG  . CYS A 1 297 ? 119.695 145.373 162.021 1.00 55.15  ? 297 CYS B SG  1 
ATOM   1500 N N   . TRP A 1 298 ? 123.341 144.164 159.543 1.00 54.09  ? 298 TRP B N   1 
ATOM   1501 C CA  . TRP A 1 298 ? 124.253 143.356 158.733 1.00 54.09  ? 298 TRP B CA  1 
ATOM   1502 C C   . TRP A 1 298 ? 125.596 144.047 158.523 1.00 54.09  ? 298 TRP B C   1 
ATOM   1503 O O   . TRP A 1 298 ? 126.574 143.400 158.136 1.00 54.09  ? 298 TRP B O   1 
ATOM   1504 C CB  . TRP A 1 298 ? 123.644 142.990 157.373 1.00 54.09  ? 298 TRP B CB  1 
ATOM   1505 C CG  . TRP A 1 298 ? 122.480 142.051 157.457 1.00 54.09  ? 298 TRP B CG  1 
ATOM   1506 C CD1 . TRP A 1 298 ? 122.528 140.688 157.451 1.00 54.09  ? 298 TRP B CD1 1 
ATOM   1507 C CD2 . TRP A 1 298 ? 121.090 142.402 157.466 1.00 54.09  ? 298 TRP B CD2 1 
ATOM   1508 N NE1 . TRP A 1 298 ? 121.258 140.169 157.513 1.00 54.09  ? 298 TRP B NE1 1 
ATOM   1509 C CE2 . TRP A 1 298 ? 120.356 141.201 157.515 1.00 54.09  ? 298 TRP B CE2 1 
ATOM   1510 C CE3 . TRP A 1 298 ? 120.396 143.613 157.451 1.00 54.09  ? 298 TRP B CE3 1 
ATOM   1511 C CZ2 . TRP A 1 298 ? 118.964 141.177 157.555 1.00 54.09  ? 298 TRP B CZ2 1 
ATOM   1512 C CZ3 . TRP A 1 298 ? 119.015 143.589 157.496 1.00 54.09  ? 298 TRP B CZ3 1 
ATOM   1513 C CH2 . TRP A 1 298 ? 118.314 142.379 157.543 1.00 54.09  ? 298 TRP B CH2 1 
ATOM   1514 N N   . SER A 1 299 ? 125.690 145.327 158.887 1.00 57.94  ? 299 SER B N   1 
ATOM   1515 C CA  . SER A 1 299 ? 126.882 146.104 158.563 1.00 57.94  ? 299 SER B CA  1 
ATOM   1516 C C   . SER A 1 299 ? 128.055 145.713 159.454 1.00 57.94  ? 299 SER B C   1 
ATOM   1517 O O   . SER A 1 299 ? 129.116 145.301 158.966 1.00 57.94  ? 299 SER B O   1 
ATOM   1518 C CB  . SER A 1 299 ? 126.577 147.596 158.687 1.00 57.94  ? 299 SER B CB  1 
ATOM   1519 O OG  . SER A 1 299 ? 125.367 147.918 158.026 1.00 57.94  ? 299 SER B OG  1 
ATOM   1520 N N   . VAL A 1 300 ? 127.886 145.849 160.772 1.00 66.00  ? 300 VAL B N   1 
ATOM   1521 C CA  . VAL A 1 300 ? 128.960 145.492 161.690 1.00 66.00  ? 300 VAL B CA  1 
ATOM   1522 C C   . VAL A 1 300 ? 129.237 143.997 161.632 1.00 66.00  ? 300 VAL B C   1 
ATOM   1523 O O   . VAL A 1 300 ? 130.374 143.564 161.846 1.00 66.00  ? 300 VAL B O   1 
ATOM   1524 C CB  . VAL A 1 300 ? 128.628 145.959 163.121 1.00 66.00  ? 300 VAL B CB  1 
ATOM   1525 C CG1 . VAL A 1 300 ? 128.494 147.473 163.166 1.00 66.00  ? 300 VAL B CG1 1 
ATOM   1526 C CG2 . VAL A 1 300 ? 127.355 145.304 163.623 1.00 66.00  ? 300 VAL B CG2 1 
ATOM   1527 N N   . TRP A 1 301 ? 128.221 143.188 161.330 1.00 66.37  ? 301 TRP B N   1 
ATOM   1528 C CA  . TRP A 1 301 ? 128.436 141.754 161.163 1.00 66.37  ? 301 TRP B CA  1 
ATOM   1529 C C   . TRP A 1 301 ? 129.357 141.466 159.982 1.00 66.37  ? 301 TRP B C   1 
ATOM   1530 O O   . TRP A 1 301 ? 130.314 140.687 160.103 1.00 66.37  ? 301 TRP B O   1 
ATOM   1531 C CB  . TRP A 1 301 ? 127.090 141.047 161.005 1.00 66.37  ? 301 TRP B CB  1 
ATOM   1532 C CG  . TRP A 1 301 ? 126.263 141.067 162.259 1.00 66.37  ? 301 TRP B CG  1 
ATOM   1533 C CD1 . TRP A 1 301 ? 126.279 140.139 163.259 1.00 66.37  ? 301 TRP B CD1 1 
ATOM   1534 C CD2 . TRP A 1 301 ? 125.333 142.079 162.668 1.00 66.37  ? 301 TRP B CD2 1 
ATOM   1535 N NE1 . TRP A 1 301 ? 125.403 140.498 164.254 1.00 66.37  ? 301 TRP B NE1 1 
ATOM   1536 C CE2 . TRP A 1 301 ? 124.810 141.686 163.916 1.00 66.37  ? 301 TRP B CE2 1 
ATOM   1537 C CE3 . TRP A 1 301 ? 124.888 143.273 162.100 1.00 66.37  ? 301 TRP B CE3 1 
ATOM   1538 C CZ2 . TRP A 1 301 ? 123.863 142.443 164.600 1.00 66.37  ? 301 TRP B CZ2 1 
ATOM   1539 C CZ3 . TRP A 1 301 ? 123.946 144.022 162.779 1.00 66.37  ? 301 TRP B CZ3 1 
ATOM   1540 C CH2 . TRP A 1 301 ? 123.445 143.606 164.016 1.00 66.37  ? 301 TRP B CH2 1 
ATOM   1541 N N   . TRP A 1 302 ? 129.099 142.100 158.832 1.00 60.91  ? 302 TRP B N   1 
ATOM   1542 C CA  . TRP A 1 302 ? 129.988 141.921 157.691 1.00 60.91  ? 302 TRP B CA  1 
ATOM   1543 C C   . TRP A 1 302 ? 131.384 142.436 158.005 1.00 60.91  ? 302 TRP B C   1 
ATOM   1544 O O   . TRP A 1 302 ? 132.385 141.809 157.638 1.00 60.91  ? 302 TRP B O   1 
ATOM   1545 C CB  . TRP A 1 302 ? 129.444 142.642 156.460 1.00 60.91  ? 302 TRP B CB  1 
ATOM   1546 C CG  . TRP A 1 302 ? 130.324 142.441 155.270 1.00 60.91  ? 302 TRP B CG  1 
ATOM   1547 C CD1 . TRP A 1 302 ? 130.569 141.263 154.627 1.00 60.91  ? 302 TRP B CD1 1 
ATOM   1548 C CD2 . TRP A 1 302 ? 131.147 143.423 154.631 1.00 60.91  ? 302 TRP B CD2 1 
ATOM   1549 N NE1 . TRP A 1 302 ? 131.456 141.460 153.598 1.00 60.91  ? 302 TRP B NE1 1 
ATOM   1550 C CE2 . TRP A 1 302 ? 131.831 142.777 153.582 1.00 60.91  ? 302 TRP B CE2 1 
ATOM   1551 C CE3 . TRP A 1 302 ? 131.358 144.790 154.832 1.00 60.91  ? 302 TRP B CE3 1 
ATOM   1552 C CZ2 . TRP A 1 302 ? 132.709 143.450 152.737 1.00 60.91  ? 302 TRP B CZ2 1 
ATOM   1553 C CZ3 . TRP A 1 302 ? 132.233 145.456 153.991 1.00 60.91  ? 302 TRP B CZ3 1 
ATOM   1554 C CH2 . TRP A 1 302 ? 132.896 144.786 152.957 1.00 60.91  ? 302 TRP B CH2 1 
ATOM   1555 N N   . ALA A 1 303 ? 131.469 143.583 158.685 1.00 62.94  ? 303 ALA B N   1 
ATOM   1556 C CA  . ALA A 1 303 ? 132.769 144.162 159.004 1.00 62.94  ? 303 ALA B CA  1 
ATOM   1557 C C   . ALA A 1 303 ? 133.575 143.250 159.919 1.00 62.94  ? 303 ALA B C   1 
ATOM   1558 O O   . ALA A 1 303 ? 134.784 143.082 159.734 1.00 62.94  ? 303 ALA B O   1 
ATOM   1559 C CB  . ALA A 1 303 ? 132.586 145.538 159.642 1.00 62.94  ? 303 ALA B CB  1 
ATOM   1560 N N   . LEU A 1 304 ? 132.923 142.638 160.906 1.00 62.47  ? 304 LEU B N   1 
ATOM   1561 C CA  . LEU A 1 304 ? 133.653 141.793 161.840 1.00 62.47  ? 304 LEU B CA  1 
ATOM   1562 C C   . LEU A 1 304 ? 134.000 140.442 161.225 1.00 62.47  ? 304 LEU B C   1 
ATOM   1563 O O   . LEU A 1 304 ? 135.040 139.862 161.559 1.00 62.47  ? 304 LEU B O   1 
ATOM   1564 C CB  . LEU A 1 304 ? 132.847 141.624 163.127 1.00 62.47  ? 304 LEU B CB  1 
ATOM   1565 C CG  . LEU A 1 304 ? 133.642 141.134 164.335 1.00 62.47  ? 304 LEU B CG  1 
ATOM   1566 C CD1 . LEU A 1 304 ? 134.727 142.140 164.653 1.00 62.47  ? 304 LEU B CD1 1 
ATOM   1567 C CD2 . LEU A 1 304 ? 132.738 140.967 165.531 1.00 62.47  ? 304 LEU B CD2 1 
ATOM   1568 N N   . SER A 1 305 ? 133.165 139.930 160.315 1.00 60.18  ? 305 SER B N   1 
ATOM   1569 C CA  . SER A 1 305 ? 133.566 138.756 159.543 1.00 60.18  ? 305 SER B CA  1 
ATOM   1570 C C   . SER A 1 305 ? 134.778 139.066 158.671 1.00 60.18  ? 305 SER B C   1 
ATOM   1571 O O   . SER A 1 305 ? 135.701 138.245 158.545 1.00 60.18  ? 305 SER B O   1 
ATOM   1572 C CB  . SER A 1 305 ? 132.399 138.273 158.686 1.00 60.18  ? 305 SER B CB  1 
ATOM   1573 O OG  . SER A 1 305 ? 131.984 139.288 157.788 1.00 60.18  ? 305 SER B OG  1 
ATOM   1574 N N   . THR A 1 306 ? 134.786 140.253 158.059 1.00 60.44  ? 306 THR B N   1 
ATOM   1575 C CA  . THR A 1 306 ? 135.944 140.702 157.298 1.00 60.44  ? 306 THR B CA  1 
ATOM   1576 C C   . THR A 1 306 ? 137.172 140.796 158.191 1.00 60.44  ? 306 THR B C   1 
ATOM   1577 O O   . THR A 1 306 ? 138.282 140.455 157.771 1.00 60.44  ? 306 THR B O   1 
ATOM   1578 C CB  . THR A 1 306 ? 135.636 142.053 156.649 1.00 60.44  ? 306 THR B CB  1 
ATOM   1579 O OG1 . THR A 1 306 ? 134.455 141.939 155.845 1.00 60.44  ? 306 THR B OG1 1 
ATOM   1580 C CG2 . THR A 1 306 ? 136.786 142.510 155.776 1.00 60.44  ? 306 THR B CG2 1 
ATOM   1581 N N   . CYS A 1 307 ? 136.987 141.267 159.425 1.00 61.55  ? 307 CYS B N   1 
ATOM   1582 C CA  . CYS A 1 307 ? 138.071 141.274 160.404 1.00 61.55  ? 307 CYS B CA  1 
ATOM   1583 C C   . CYS A 1 307 ? 138.615 139.877 160.643 1.00 61.55  ? 307 CYS B C   1 
ATOM   1584 O O   . CYS A 1 307 ? 139.833 139.659 160.621 1.00 61.55  ? 307 CYS B O   1 
ATOM   1585 C CB  . CYS A 1 307 ? 137.588 141.881 161.718 1.00 61.55  ? 307 CYS B CB  1 
ATOM   1586 S SG  . CYS A 1 307 ? 138.879 141.986 162.977 1.00 61.55  ? 307 CYS B SG  1 
ATOM   1587 N N   . GLY A 1 308 ? 137.721 138.921 160.892 1.00 58.77  ? 308 GLY B N   1 
ATOM   1588 C CA  . GLY A 1 308 ? 138.166 137.562 161.146 1.00 58.77  ? 308 GLY B CA  1 
ATOM   1589 C C   . GLY A 1 308 ? 138.984 137.010 159.997 1.00 58.77  ? 308 GLY B C   1 
ATOM   1590 O O   . GLY A 1 308 ? 140.079 136.474 160.196 1.00 58.77  ? 308 GLY B O   1 
ATOM   1591 N N   . TYR A 1 309 ? 138.488 137.182 158.772 1.00 55.08  ? 309 TYR B N   1 
ATOM   1592 C CA  . TYR A 1 309 ? 139.229 136.668 157.623 1.00 55.08  ? 309 TYR B CA  1 
ATOM   1593 C C   . TYR A 1 309 ? 140.552 137.394 157.416 1.00 55.08  ? 309 TYR B C   1 
ATOM   1594 O O   . TYR A 1 309 ? 141.587 136.754 157.203 1.00 55.08  ? 309 TYR B O   1 
ATOM   1595 C CB  . TYR A 1 309 ? 138.382 136.717 156.357 1.00 55.08  ? 309 TYR B CB  1 
ATOM   1596 C CG  . TYR A 1 309 ? 139.010 135.905 155.251 1.00 55.08  ? 309 TYR B CG  1 
ATOM   1597 C CD1 . TYR A 1 309 ? 138.626 134.600 155.015 1.00 55.08  ? 309 TYR B CD1 1 
ATOM   1598 C CD2 . TYR A 1 309 ? 139.967 136.469 154.413 1.00 55.08  ? 309 TYR B CD2 1 
ATOM   1599 C CE1 . TYR A 1 309 ? 139.192 133.870 154.000 1.00 55.08  ? 309 TYR B CE1 1 
ATOM   1600 C CE2 . TYR A 1 309 ? 140.538 135.747 153.397 1.00 55.08  ? 309 TYR B CE2 1 
ATOM   1601 C CZ  . TYR A 1 309 ? 140.149 134.447 153.193 1.00 55.08  ? 309 TYR B CZ  1 
ATOM   1602 O OH  . TYR A 1 309 ? 140.721 133.725 152.174 1.00 55.08  ? 309 TYR B OH  1 
ATOM   1603 N N   . PHE A 1 310 ? 140.545 138.725 157.430 1.00 54.79  ? 310 PHE B N   1 
ATOM   1604 C CA  . PHE A 1 310 ? 141.794 139.423 157.167 1.00 54.79  ? 310 PHE B CA  1 
ATOM   1605 C C   . PHE A 1 310 ? 142.793 139.275 158.301 1.00 54.79  ? 310 PHE B C   1 
ATOM   1606 O O   . PHE A 1 310 ? 143.970 139.597 158.110 1.00 54.79  ? 310 PHE B O   1 
ATOM   1607 C CB  . PHE A 1 310 ? 141.536 140.900 156.884 1.00 54.79  ? 310 PHE B CB  1 
ATOM   1608 C CG  . PHE A 1 310 ? 141.236 141.187 155.445 1.00 54.79  ? 310 PHE B CG  1 
ATOM   1609 C CD1 . PHE A 1 310 ? 142.262 141.323 154.527 1.00 54.79  ? 310 PHE B CD1 1 
ATOM   1610 C CD2 . PHE A 1 310 ? 139.931 141.311 155.007 1.00 54.79  ? 310 PHE B CD2 1 
ATOM   1611 C CE1 . PHE A 1 310 ? 141.993 141.584 153.197 1.00 54.79  ? 310 PHE B CE1 1 
ATOM   1612 C CE2 . PHE A 1 310 ? 139.652 141.573 153.679 1.00 54.79  ? 310 PHE B CE2 1 
ATOM   1613 C CZ  . PHE A 1 310 ? 140.685 141.710 152.772 1.00 54.79  ? 310 PHE B CZ  1 
ATOM   1614 N N   . GLN A 1 311 ? 142.364 138.791 159.463 1.00 51.02  ? 311 GLN B N   1 
ATOM   1615 C CA  . GLN A 1 311 ? 143.314 138.444 160.506 1.00 51.02  ? 311 GLN B CA  1 
ATOM   1616 C C   . GLN A 1 311 ? 143.834 137.020 160.372 1.00 51.02  ? 311 GLN B C   1 
ATOM   1617 O O   . GLN A 1 311 ? 145.003 136.769 160.685 1.00 51.02  ? 311 GLN B O   1 
ATOM   1618 C CB  . GLN A 1 311 ? 142.671 138.628 161.883 1.00 51.02  ? 311 GLN B CB  1 
ATOM   1619 C CG  . GLN A 1 311 ? 143.664 138.791 163.018 1.00 51.02  ? 311 GLN B CG  1 
ATOM   1620 C CD  . GLN A 1 311 ? 142.990 139.177 164.316 1.00 51.02  ? 311 GLN B CD  1 
ATOM   1621 O OE1 . GLN A 1 311 ? 141.768 139.300 164.378 1.00 51.02  ? 311 GLN B OE1 1 
ATOM   1622 N NE2 . GLN A 1 311 ? 143.784 139.373 165.361 1.00 51.02  ? 311 GLN B NE2 1 
ATOM   1623 N N   . VAL A 1 312 ? 143.009 136.081 159.908 1.00 48.02  ? 312 VAL B N   1 
ATOM   1624 C CA  . VAL A 1 312 ? 143.447 134.688 159.894 1.00 48.02  ? 312 VAL B CA  1 
ATOM   1625 C C   . VAL A 1 312 ? 144.141 134.288 158.592 1.00 48.02  ? 312 VAL B C   1 
ATOM   1626 O O   . VAL A 1 312 ? 144.976 133.377 158.600 1.00 48.02  ? 312 VAL B O   1 
ATOM   1627 C CB  . VAL A 1 312 ? 142.267 133.746 160.188 1.00 48.02  ? 312 VAL B CB  1 
ATOM   1628 C CG1 . VAL A 1 312 ? 141.632 134.088 161.525 1.00 48.02  ? 312 VAL B CG1 1 
ATOM   1629 C CG2 . VAL A 1 312 ? 141.248 133.793 159.066 1.00 48.02  ? 312 VAL B CG2 1 
ATOM   1630 N N   . VAL A 1 313 ? 143.816 134.933 157.469 1.00 50.00  ? 313 VAL B N   1 
ATOM   1631 C CA  . VAL A 1 313 ? 144.352 134.481 156.188 1.00 50.00  ? 313 VAL B CA  1 
ATOM   1632 C C   . VAL A 1 313 ? 145.853 134.730 156.112 1.00 50.00  ? 313 VAL B C   1 
ATOM   1633 O O   . VAL A 1 313 ? 146.598 133.934 155.528 1.00 50.00  ? 313 VAL B O   1 
ATOM   1634 C CB  . VAL A 1 313 ? 143.598 135.148 155.021 1.00 50.00  ? 313 VAL B CB  1 
ATOM   1635 C CG1 . VAL A 1 313 ? 143.820 136.656 155.001 1.00 50.00  ? 313 VAL B CG1 1 
ATOM   1636 C CG2 . VAL A 1 313 ? 144.009 134.526 153.696 1.00 50.00  ? 313 VAL B CG2 1 
ATOM   1637 N N   . ASN A 1 314 ? 146.323 135.832 156.702 1.00 46.86  ? 314 ASN B N   1 
ATOM   1638 C CA  . ASN A 1 314 ? 147.739 136.169 156.616 1.00 46.86  ? 314 ASN B CA  1 
ATOM   1639 C C   . ASN A 1 314 ? 148.590 135.194 157.419 1.00 46.86  ? 314 ASN B C   1 
ATOM   1640 O O   . ASN A 1 314 ? 149.675 134.796 156.979 1.00 46.86  ? 314 ASN B O   1 
ATOM   1641 C CB  . ASN A 1 314 ? 147.961 137.601 157.097 1.00 46.86  ? 314 ASN B CB  1 
ATOM   1642 C CG  . ASN A 1 314 ? 147.264 138.621 156.222 1.00 46.86  ? 314 ASN B CG  1 
ATOM   1643 O OD1 . ASN A 1 314 ? 146.343 139.305 156.662 1.00 46.86  ? 314 ASN B OD1 1 
ATOM   1644 N ND2 . ASN A 1 314 ? 147.696 138.721 154.972 1.00 46.86  ? 314 ASN B ND2 1 
ATOM   1645 N N   . TYR A 1 315 ? 148.116 134.798 158.596 1.00 47.74  ? 315 TYR B N   1 
ATOM   1646 C CA  . TYR A 1 315 ? 148.880 133.934 159.480 1.00 47.74  ? 315 TYR B CA  1 
ATOM   1647 C C   . TYR A 1 315 ? 148.534 132.459 159.330 1.00 47.74  ? 315 TYR B C   1 
ATOM   1648 O O   . TYR A 1 315 ? 149.132 131.626 160.023 1.00 47.74  ? 315 TYR B O   1 
ATOM   1649 C CB  . TYR A 1 315 ? 148.679 134.371 160.932 1.00 47.74  ? 315 TYR B CB  1 
ATOM   1650 C CG  . TYR A 1 315 ? 149.045 135.819 161.174 1.00 47.74  ? 315 TYR B CG  1 
ATOM   1651 C CD1 . TYR A 1 315 ? 148.099 136.826 161.046 1.00 47.74  ? 315 TYR B CD1 1 
ATOM   1652 C CD2 . TYR A 1 315 ? 150.341 136.179 161.519 1.00 47.74  ? 315 TYR B CD2 1 
ATOM   1653 C CE1 . TYR A 1 315 ? 148.429 138.152 161.262 1.00 47.74  ? 315 TYR B CE1 1 
ATOM   1654 C CE2 . TYR A 1 315 ? 150.680 137.503 161.738 1.00 47.74  ? 315 TYR B CE2 1 
ATOM   1655 C CZ  . TYR A 1 315 ? 149.721 138.484 161.607 1.00 47.74  ? 315 TYR B CZ  1 
ATOM   1656 O OH  . TYR A 1 315 ? 150.052 139.801 161.823 1.00 47.74  ? 315 TYR B OH  1 
ATOM   1657 N N   . THR A 1 316 ? 147.594 132.115 158.448 1.00 44.17  ? 316 THR B N   1 
ATOM   1658 C CA  . THR A 1 316 ? 147.354 130.708 158.147 1.00 44.17  ? 316 THR B CA  1 
ATOM   1659 C C   . THR A 1 316 ? 148.597 130.059 157.552 1.00 44.17  ? 316 THR B C   1 
ATOM   1660 O O   . THR A 1 316 ? 148.914 128.902 157.857 1.00 44.17  ? 316 THR B O   1 
ATOM   1661 C CB  . THR A 1 316 ? 146.168 130.582 157.192 1.00 44.17  ? 316 THR B CB  1 
ATOM   1662 O OG1 . THR A 1 316 ? 145.003 131.145 157.806 1.00 44.17  ? 316 THR B OG1 1 
ATOM   1663 C CG2 . THR A 1 316 ? 145.897 129.125 156.873 1.00 44.17  ? 316 THR B CG2 1 
ATOM   1664 N N   . GLN A 1 317 ? 149.318 130.796 156.703 1.00 44.22  ? 317 GLN B N   1 
ATOM   1665 C CA  . GLN A 1 317 ? 150.578 130.298 156.161 1.00 44.22  ? 317 GLN B CA  1 
ATOM   1666 C C   . GLN A 1 317 ? 151.576 130.003 157.272 1.00 44.22  ? 317 GLN B C   1 
ATOM   1667 O O   . GLN A 1 317 ? 152.233 128.954 157.268 1.00 44.22  ? 317 GLN B O   1 
ATOM   1668 C CB  . GLN A 1 317 ? 151.163 131.320 155.187 1.00 44.22  ? 317 GLN B CB  1 
ATOM   1669 C CG  . GLN A 1 317 ? 150.350 131.539 153.926 1.00 44.22  ? 317 GLN B CG  1 
ATOM   1670 C CD  . GLN A 1 317 ? 150.331 130.320 153.031 1.00 44.22  ? 317 GLN B CD  1 
ATOM   1671 O OE1 . GLN A 1 317 ? 149.307 129.651 152.894 1.00 44.22  ? 317 GLN B OE1 1 
ATOM   1672 N NE2 . GLN A 1 317 ? 151.469 130.023 152.413 1.00 44.22  ? 317 GLN B NE2 1 
ATOM   1673 N N   . GLY A 1 318 ? 151.705 130.922 158.230 1.00 42.93  ? 318 GLY B N   1 
ATOM   1674 C CA  . GLY A 1 318 ? 152.620 130.699 159.335 1.00 42.93  ? 318 GLY B CA  1 
ATOM   1675 C C   . GLY A 1 318 ? 152.223 129.510 160.186 1.00 42.93  ? 318 GLY B C   1 
ATOM   1676 O O   . GLY A 1 318 ? 153.077 128.741 160.629 1.00 42.93  ? 318 GLY B O   1 
ATOM   1677 N N   . LEU A 1 319 ? 150.922 129.344 160.424 1.00 39.56  ? 319 LEU B N   1 
ATOM   1678 C CA  . LEU A 1 319 ? 150.459 128.189 161.187 1.00 39.56  ? 319 LEU B CA  1 
ATOM   1679 C C   . LEU A 1 319 ? 150.775 126.889 160.456 1.00 39.56  ? 319 LEU B C   1 
ATOM   1680 O O   . LEU A 1 319 ? 151.232 125.917 161.071 1.00 39.56  ? 319 LEU B O   1 
ATOM   1681 C CB  . LEU A 1 319 ? 148.960 128.316 161.465 1.00 39.56  ? 319 LEU B CB  1 
ATOM   1682 C CG  . LEU A 1 319 ? 148.277 127.342 162.432 1.00 39.56  ? 319 LEU B CG  1 
ATOM   1683 C CD1 . LEU A 1 319 ? 147.099 128.033 163.099 1.00 39.56  ? 319 LEU B CD1 1 
ATOM   1684 C CD2 . LEU A 1 319 ? 147.803 126.071 161.737 1.00 39.56  ? 319 LEU B CD2 1 
ATOM   1685 N N   . TRP A 1 320 ? 150.546 126.856 159.140 1.00 39.05  ? 320 TRP B N   1 
ATOM   1686 C CA  . TRP A 1 320 ? 150.847 125.655 158.366 1.00 39.05  ? 320 TRP B CA  1 
ATOM   1687 C C   . TRP A 1 320 ? 152.337 125.346 158.387 1.00 39.05  ? 320 TRP B C   1 
ATOM   1688 O O   . TRP A 1 320 ? 152.737 124.179 158.474 1.00 39.05  ? 320 TRP B O   1 
ATOM   1689 C CB  . TRP A 1 320 ? 150.356 125.816 156.927 1.00 39.05  ? 320 TRP B CB  1 
ATOM   1690 C CG  . TRP A 1 320 ? 148.882 125.626 156.771 1.00 39.05  ? 320 TRP B CG  1 
ATOM   1691 C CD1 . TRP A 1 320 ? 148.057 124.922 157.594 1.00 39.05  ? 320 TRP B CD1 1 
ATOM   1692 C CD2 . TRP A 1 320 ? 148.054 126.153 155.727 1.00 39.05  ? 320 TRP B CD2 1 
ATOM   1693 N NE1 . TRP A 1 320 ? 146.766 124.975 157.129 1.00 39.05  ? 320 TRP B NE1 1 
ATOM   1694 C CE2 . TRP A 1 320 ? 146.737 125.726 155.984 1.00 39.05  ? 320 TRP B CE2 1 
ATOM   1695 C CE3 . TRP A 1 320 ? 148.299 126.944 154.601 1.00 39.05  ? 320 TRP B CE3 1 
ATOM   1696 C CZ2 . TRP A 1 320 ? 145.668 126.062 155.155 1.00 39.05  ? 320 TRP B CZ2 1 
ATOM   1697 C CZ3 . TRP A 1 320 ? 147.235 127.278 153.780 1.00 39.05  ? 320 TRP B CZ3 1 
ATOM   1698 C CH2 . TRP A 1 320 ? 145.937 126.838 154.061 1.00 39.05  ? 320 TRP B CH2 1 
ATOM   1699 N N   . GLU A 1 321 ? 153.175 126.380 158.299 1.00 46.76  ? 321 GLU B N   1 
ATOM   1700 C CA  . GLU A 1 321 ? 154.617 126.160 158.327 1.00 46.76  ? 321 GLU B CA  1 
ATOM   1701 C C   . GLU A 1 321 ? 155.081 125.694 159.702 1.00 46.76  ? 321 GLU B C   1 
ATOM   1702 O O   . GLU A 1 321 ? 155.994 124.866 159.806 1.00 46.76  ? 321 GLU B O   1 
ATOM   1703 C CB  . GLU A 1 321 ? 155.352 127.435 157.916 1.00 46.76  ? 321 GLU B CB  1 
ATOM   1704 C CG  . GLU A 1 321 ? 156.835 127.258 157.589 1.00 46.76  ? 321 GLU B CG  1 
ATOM   1705 C CD  . GLU A 1 321 ? 157.106 126.179 156.550 1.00 46.76  ? 321 GLU B CD  1 
ATOM   1706 O OE1 . GLU A 1 321 ? 157.173 124.988 156.916 1.00 46.76  ? 321 GLU B OE1 1 
ATOM   1707 O OE2 . GLU A 1 321 ? 157.257 126.527 155.360 1.00 46.76  ? 321 GLU B OE2 1 
ATOM   1708 N N   . LYS A 1 322 ? 154.473 126.216 160.769 1.00 41.10  ? 322 LYS B N   1 
ATOM   1709 C CA  . LYS A 1 322 ? 154.914 125.857 162.111 1.00 41.10  ? 322 LYS B CA  1 
ATOM   1710 C C   . LYS A 1 322 ? 154.426 124.476 162.531 1.00 41.10  ? 322 LYS B C   1 
ATOM   1711 O O   . LYS A 1 322 ? 155.115 123.794 163.297 1.00 41.10  ? 322 LYS B O   1 
ATOM   1712 C CB  . LYS A 1 322 ? 154.468 126.921 163.119 1.00 41.10  ? 322 LYS B CB  1 
ATOM   1713 C CG  . LYS A 1 322 ? 153.008 126.856 163.530 1.00 41.10  ? 322 LYS B CG  1 
ATOM   1714 C CD  . LYS A 1 322 ? 152.606 128.079 164.333 1.00 41.10  ? 322 LYS B CD  1 
ATOM   1715 C CE  . LYS A 1 322 ? 151.174 127.965 164.811 1.00 41.10  ? 322 LYS B CE  1 
ATOM   1716 N NZ  . LYS A 1 322 ? 151.053 126.986 165.924 1.00 41.10  ? 322 LYS B NZ  1 
ATOM   1717 N N   . VAL A 1 323 ? 153.259 124.040 162.050 1.00 43.27  ? 323 VAL B N   1 
ATOM   1718 C CA  . VAL A 1 323 ? 152.825 122.681 162.357 1.00 43.27  ? 323 VAL B CA  1 
ATOM   1719 C C   . VAL A 1 323 ? 153.556 121.651 161.508 1.00 43.27  ? 323 VAL B C   1 
ATOM   1720 O O   . VAL A 1 323 ? 153.557 120.463 161.855 1.00 43.27  ? 323 VAL B O   1 
ATOM   1721 C CB  . VAL A 1 323 ? 151.307 122.512 162.178 1.00 43.27  ? 323 VAL B CB  1 
ATOM   1722 C CG1 . VAL A 1 323 ? 150.555 123.464 163.089 1.00 43.27  ? 323 VAL B CG1 1 
ATOM   1723 C CG2 . VAL A 1 323 ? 150.910 122.719 160.727 1.00 43.27  ? 323 VAL B CG2 1 
ATOM   1724 N N   . MET A 1 324 ? 154.183 122.072 160.412 1.00 45.76  ? 324 MET B N   1 
ATOM   1725 C CA  . MET A 1 324 ? 154.906 121.161 159.525 1.00 45.76  ? 324 MET B CA  1 
ATOM   1726 C C   . MET A 1 324 ? 156.016 121.947 158.845 1.00 45.76  ? 324 MET B C   1 
ATOM   1727 O O   . MET A 1 324 ? 155.756 122.744 157.930 1.00 45.76  ? 324 MET B O   1 
ATOM   1728 C CB  . MET A 1 324 ? 153.978 120.523 158.495 1.00 45.76  ? 324 MET B CB  1 
ATOM   1729 N N   . PRO A 1 325 ? 157.268 121.759 159.265 1.00 49.99  ? 325 PRO B N   1 
ATOM   1730 C CA  . PRO A 1 325 ? 158.371 122.504 158.647 1.00 49.99  ? 325 PRO B CA  1 
ATOM   1731 C C   . PRO A 1 325 ? 158.583 122.092 157.199 1.00 49.99  ? 325 PRO B C   1 
ATOM   1732 O O   . PRO A 1 325 ? 158.394 120.932 156.828 1.00 49.99  ? 325 PRO B O   1 
ATOM   1733 C CB  . PRO A 1 325 ? 159.578 122.134 159.515 1.00 49.99  ? 325 PRO B CB  1 
ATOM   1734 C CG  . PRO A 1 325 ? 159.237 120.792 160.063 1.00 49.99  ? 325 PRO B CG  1 
ATOM   1735 C CD  . PRO A 1 325 ? 157.745 120.799 160.275 1.00 49.99  ? 325 PRO B CD  1 
ATOM   1736 N N   . SER A 1 326 ? 158.995 123.061 156.382 1.00 55.89  ? 326 SER B N   1 
ATOM   1737 C CA  . SER A 1 326 ? 159.229 122.812 154.966 1.00 55.89  ? 326 SER B CA  1 
ATOM   1738 C C   . SER A 1 326 ? 160.576 122.157 154.696 1.00 55.89  ? 326 SER B C   1 
ATOM   1739 O O   . SER A 1 326 ? 160.844 121.787 153.548 1.00 55.89  ? 326 SER B O   1 
ATOM   1740 C CB  . SER A 1 326 ? 159.126 124.120 154.179 1.00 55.89  ? 326 SER B CB  1 
ATOM   1741 O OG  . SER A 1 326 ? 160.282 124.919 154.360 1.00 55.89  ? 326 SER B OG  1 
ATOM   1742 N N   . ARG A 1 327 ? 161.425 122.015 155.716 1.00 59.49  ? 327 ARG B N   1 
ATOM   1743 C CA  . ARG A 1 327 ? 162.729 121.390 155.518 1.00 59.49  ? 327 ARG B CA  1 
ATOM   1744 C C   . ARG A 1 327 ? 162.589 119.921 155.138 1.00 59.49  ? 327 ARG B C   1 
ATOM   1745 O O   . ARG A 1 327 ? 163.340 119.415 154.295 1.00 59.49  ? 327 ARG B O   1 
ATOM   1746 C CB  . ARG A 1 327 ? 163.579 121.540 156.780 1.00 59.49  ? 327 ARG B CB  1 
ATOM   1747 N N   . TYR A 1 328 ? 161.637 119.217 155.750 1.00 63.24  ? 328 TYR B N   1 
ATOM   1748 C CA  . TYR A 1 328 ? 161.422 117.801 155.480 1.00 63.24  ? 328 TYR B CA  1 
ATOM   1749 C C   . TYR A 1 328 ? 159.981 117.528 155.063 1.00 63.24  ? 328 TYR B C   1 
ATOM   1750 O O   . TYR A 1 328 ? 159.461 116.433 155.293 1.00 63.24  ? 328 TYR B O   1 
ATOM   1751 C CB  . TYR A 1 328 ? 161.798 116.952 156.694 1.00 63.24  ? 328 TYR B CB  1 
ATOM   1752 N N   . ALA A 1 329 ? 159.324 118.510 154.450 1.00 61.75  ? 329 ALA B N   1 
ATOM   1753 C CA  . ALA A 1 329 ? 157.953 118.335 153.992 1.00 61.75  ? 329 ALA B CA  1 
ATOM   1754 C C   . ALA A 1 329 ? 157.664 119.338 152.885 1.00 61.75  ? 329 ALA B C   1 
ATOM   1755 O O   . ALA A 1 329 ? 158.342 120.361 152.755 1.00 61.75  ? 329 ALA B O   1 
ATOM   1756 C CB  . ALA A 1 329 ? 156.950 118.494 155.140 1.00 61.75  ? 329 ALA B CB  1 
ATOM   1757 N N   . ALA A 1 330 ? 156.643 119.028 152.090 1.00 54.04  ? 330 ALA B N   1 
ATOM   1758 C CA  . ALA A 1 330 ? 156.185 119.887 151.007 1.00 54.04  ? 330 ALA B CA  1 
ATOM   1759 C C   . ALA A 1 330 ? 154.770 120.367 151.298 1.00 54.04  ? 330 ALA B C   1 
ATOM   1760 O O   . ALA A 1 330 ? 153.913 119.583 151.716 1.00 54.04  ? 330 ALA B O   1 
ATOM   1761 C CB  . ALA A 1 330 ? 156.225 119.152 149.665 1.00 54.04  ? 330 ALA B CB  1 
ATOM   1762 N N   . ILE A 1 331 ? 154.528 121.655 151.065 1.00 52.80  ? 331 ILE B N   1 
ATOM   1763 C CA  . ILE A 1 331 ? 153.266 122.303 151.403 1.00 52.80  ? 331 ILE B CA  1 
ATOM   1764 C C   . ILE A 1 331 ? 152.454 122.506 150.129 1.00 52.80  ? 331 ILE B C   1 
ATOM   1765 O O   . ILE A 1 331 ? 152.972 122.994 149.118 1.00 52.80  ? 331 ILE B O   1 
ATOM   1766 C CB  . ILE A 1 331 ? 153.503 123.626 152.159 1.00 52.80  ? 331 ILE B CB  1 
ATOM   1767 C CG1 . ILE A 1 331 ? 152.191 124.174 152.727 1.00 52.80  ? 331 ILE B CG1 1 
ATOM   1768 C CG2 . ILE A 1 331 ? 154.267 124.646 151.311 1.00 52.80  ? 331 ILE B CG2 1 
ATOM   1769 C CD1 . ILE A 1 331 ? 152.383 125.283 153.741 1.00 52.80  ? 331 ILE B CD1 1 
ATOM   1770 N N   . TYR A 1 332 ? 151.195 122.074 150.164 1.00 53.85  ? 332 TYR B N   1 
ATOM   1771 C CA  . TYR A 1 332 ? 150.320 122.123 148.993 1.00 53.85  ? 332 TYR B CA  1 
ATOM   1772 C C   . TYR A 1 332 ? 149.355 123.305 149.100 1.00 53.85  ? 332 TYR B C   1 
ATOM   1773 O O   . TYR A 1 332 ? 148.145 123.150 149.262 1.00 53.85  ? 332 TYR B O   1 
ATOM   1774 C CB  . TYR A 1 332 ? 149.574 120.800 148.840 1.00 53.85  ? 332 TYR B CB  1 
ATOM   1775 C CG  . TYR A 1 332 ? 150.470 119.579 148.860 1.00 53.85  ? 332 TYR B CG  1 
ATOM   1776 C CD1 . TYR A 1 332 ? 151.758 119.625 148.340 1.00 53.85  ? 332 TYR B CD1 1 
ATOM   1777 C CD2 . TYR A 1 332 ? 150.027 118.381 149.403 1.00 53.85  ? 332 TYR B CD2 1 
ATOM   1778 C CE1 . TYR A 1 332 ? 152.577 118.513 148.361 1.00 53.85  ? 332 TYR B CE1 1 
ATOM   1779 C CE2 . TYR A 1 332 ? 150.838 117.263 149.427 1.00 53.85  ? 332 TYR B CE2 1 
ATOM   1780 C CZ  . TYR A 1 332 ? 152.112 117.335 148.904 1.00 53.85  ? 332 TYR B CZ  1 
ATOM   1781 O OH  . TYR A 1 332 ? 152.923 116.223 148.926 1.00 53.85  ? 332 TYR B OH  1 
ATOM   1782 N N   . ASN A 1 333 ? 149.918 124.510 148.999 1.00 55.27  ? 333 ASN B N   1 
ATOM   1783 C CA  . ASN A 1 333 ? 149.100 125.714 149.109 1.00 55.27  ? 333 ASN B CA  1 
ATOM   1784 C C   . ASN A 1 333 ? 148.312 125.995 147.834 1.00 55.27  ? 333 ASN B C   1 
ATOM   1785 O O   . ASN A 1 333 ? 147.180 126.490 147.900 1.00 55.27  ? 333 ASN B O   1 
ATOM   1786 C CB  . ASN A 1 333 ? 149.973 126.918 149.453 1.00 55.27  ? 333 ASN B CB  1 
ATOM   1787 C CG  . ASN A 1 333 ? 150.687 126.756 150.771 1.00 55.27  ? 333 ASN B CG  1 
ATOM   1788 O OD1 . ASN A 1 333 ? 151.915 126.760 150.826 1.00 55.27  ? 333 ASN B OD1 1 
ATOM   1789 N ND2 . ASN A 1 333 ? 149.922 126.611 151.845 1.00 55.27  ? 333 ASN B ND2 1 
ATOM   1790 N N   . GLY A 1 334 ? 148.896 125.707 146.670 1.00 57.28  ? 334 GLY B N   1 
ATOM   1791 C CA  . GLY A 1 334 ? 148.238 126.056 145.420 1.00 57.28  ? 334 GLY B CA  1 
ATOM   1792 C C   . GLY A 1 334 ? 146.919 125.332 145.231 1.00 57.28  ? 334 GLY B C   1 
ATOM   1793 O O   . GLY A 1 334 ? 145.903 125.943 144.890 1.00 57.28  ? 334 GLY B O   1 
ATOM   1794 N N   . GLY A 1 335 ? 146.914 124.021 145.474 1.00 57.10  ? 335 GLY B N   1 
ATOM   1795 C CA  . GLY A 1 335 ? 145.694 123.253 145.294 1.00 57.10  ? 335 GLY B CA  1 
ATOM   1796 C C   . GLY A 1 335 ? 144.597 123.657 146.259 1.00 57.10  ? 335 GLY B C   1 
ATOM   1797 O O   . GLY A 1 335 ? 143.433 123.788 145.868 1.00 57.10  ? 335 GLY B O   1 
ATOM   1798 N N   . VAL A 1 336 ? 144.948 123.858 147.531 1.00 57.29  ? 336 VAL B N   1 
ATOM   1799 C CA  . VAL A 1 336 ? 143.938 124.223 148.519 1.00 57.29  ? 336 VAL B CA  1 
ATOM   1800 C C   . VAL A 1 336 ? 143.383 125.612 148.229 1.00 57.29  ? 336 VAL B C   1 
ATOM   1801 O O   . VAL A 1 336 ? 142.170 125.832 148.314 1.00 57.29  ? 336 VAL B O   1 
ATOM   1802 C CB  . VAL A 1 336 ? 144.495 124.101 149.953 1.00 57.29  ? 336 VAL B CB  1 
ATOM   1803 C CG1 . VAL A 1 336 ? 145.672 125.018 150.181 1.00 57.29  ? 336 VAL B CG1 1 
ATOM   1804 C CG2 . VAL A 1 336 ? 143.410 124.404 150.963 1.00 57.29  ? 336 VAL B CG2 1 
ATOM   1805 N N   . GLU A 1 337 ? 144.245 126.560 147.845 1.00 55.38  ? 337 GLU B N   1 
ATOM   1806 C CA  . GLU A 1 337 ? 143.749 127.883 147.481 1.00 55.38  ? 337 GLU B CA  1 
ATOM   1807 C C   . GLU A 1 337 ? 142.840 127.814 146.261 1.00 55.38  ? 337 GLU B C   1 
ATOM   1808 O O   . GLU A 1 337 ? 141.781 128.454 146.231 1.00 55.38  ? 337 GLU B O   1 
ATOM   1809 C CB  . GLU A 1 337 ? 144.914 128.839 147.230 1.00 55.38  ? 337 GLU B CB  1 
ATOM   1810 C CG  . GLU A 1 337 ? 145.691 129.210 148.481 1.00 55.38  ? 337 GLU B CG  1 
ATOM   1811 C CD  . GLU A 1 337 ? 145.207 130.503 149.107 1.00 55.38  ? 337 GLU B CD  1 
ATOM   1812 O OE1 . GLU A 1 337 ? 144.153 131.014 148.676 1.00 55.38  ? 337 GLU B OE1 1 
ATOM   1813 O OE2 . GLU A 1 337 ? 145.879 131.008 150.031 1.00 55.38  ? 337 GLU B OE2 1 
ATOM   1814 N N   . ALA A 1 338 ? 143.226 127.027 145.254 1.00 63.04  ? 338 ALA B N   1 
ATOM   1815 C CA  . ALA A 1 338 ? 142.419 126.925 144.043 1.00 63.04  ? 338 ALA B CA  1 
ATOM   1816 C C   . ALA A 1 338 ? 141.048 126.336 144.342 1.00 63.04  ? 338 ALA B C   1 
ATOM   1817 O O   . ALA A 1 338 ? 140.022 126.891 143.933 1.00 63.04  ? 338 ALA B O   1 
ATOM   1818 C CB  . ALA A 1 338 ? 143.149 126.085 142.996 1.00 63.04  ? 338 ALA B CB  1 
ATOM   1819 N N   . VAL A 1 339 ? 141.009 125.213 145.065 1.00 64.15  ? 339 VAL B N   1 
ATOM   1820 C CA  . VAL A 1 339 ? 139.726 124.574 145.343 1.00 64.15  ? 339 VAL B CA  1 
ATOM   1821 C C   . VAL A 1 339 ? 138.880 125.451 146.258 1.00 64.15  ? 339 VAL B C   1 
ATOM   1822 O O   . VAL A 1 339 ? 137.654 125.522 146.105 1.00 64.15  ? 339 VAL B O   1 
ATOM   1823 C CB  . VAL A 1 339 ? 139.926 123.156 145.916 1.00 64.15  ? 339 VAL B CB  1 
ATOM   1824 C CG1 . VAL A 1 339 ? 140.692 122.287 144.931 1.00 64.15  ? 339 VAL B CG1 1 
ATOM   1825 C CG2 . VAL A 1 339 ? 140.628 123.185 147.263 1.00 64.15  ? 339 VAL B CG2 1 
ATOM   1826 N N   . SER A 1 340 ? 139.514 126.159 147.198 1.00 63.18  ? 340 SER B N   1 
ATOM   1827 C CA  . SER A 1 340 ? 138.771 127.029 148.100 1.00 63.18  ? 340 SER B CA  1 
ATOM   1828 C C   . SER A 1 340 ? 138.115 128.176 147.345 1.00 63.18  ? 340 SER B C   1 
ATOM   1829 O O   . SER A 1 340 ? 136.923 128.448 147.523 1.00 63.18  ? 340 SER B O   1 
ATOM   1830 C CB  . SER A 1 340 ? 139.700 127.563 149.186 1.00 63.18  ? 340 SER B CB  1 
ATOM   1831 O OG  . SER A 1 340 ? 139.095 128.648 149.856 1.00 63.18  ? 340 SER B OG  1 
ATOM   1832 N N   . THR A 1 341 ? 138.879 128.859 146.489 1.00 65.90  ? 341 THR B N   1 
ATOM   1833 C CA  . THR A 1 341 ? 138.306 129.950 145.707 1.00 65.90  ? 341 THR B CA  1 
ATOM   1834 C C   . THR A 1 341 ? 137.247 129.442 144.734 1.00 65.90  ? 341 THR B C   1 
ATOM   1835 O O   . THR A 1 341 ? 136.222 130.105 144.526 1.00 65.90  ? 341 THR B O   1 
ATOM   1836 C CB  . THR A 1 341 ? 139.407 130.705 144.965 1.00 65.90  ? 341 THR B CB  1 
ATOM   1837 O OG1 . THR A 1 341 ? 140.076 129.817 144.062 1.00 65.90  ? 341 THR B OG1 1 
ATOM   1838 C CG2 . THR A 1 341 ? 140.409 131.295 145.947 1.00 65.90  ? 341 THR B CG2 1 
ATOM   1839 N N   . LEU A 1 342 ? 137.470 128.271 144.131 1.00 74.09  ? 342 LEU B N   1 
ATOM   1840 C CA  . LEU A 1 342 ? 136.496 127.727 143.190 1.00 74.09  ? 342 LEU B CA  1 
ATOM   1841 C C   . LEU A 1 342 ? 135.177 127.413 143.885 1.00 74.09  ? 342 LEU B C   1 
ATOM   1842 O O   . LEU A 1 342 ? 134.101 127.779 143.395 1.00 74.09  ? 342 LEU B O   1 
ATOM   1843 C CB  . LEU A 1 342 ? 137.067 126.478 142.517 1.00 74.09  ? 342 LEU B CB  1 
ATOM   1844 C CG  . LEU A 1 342 ? 136.648 126.206 141.071 1.00 74.09  ? 342 LEU B CG  1 
ATOM   1845 C CD1 . LEU A 1 342 ? 136.918 127.420 140.197 1.00 74.09  ? 342 LEU B CD1 1 
ATOM   1846 C CD2 . LEU A 1 342 ? 137.373 124.982 140.528 1.00 74.09  ? 342 LEU B CD2 1 
ATOM   1847 N N   . LEU A 1 343 ? 135.240 126.747 145.040 1.00 74.71  ? 343 LEU B N   1 
ATOM   1848 C CA  . LEU A 1 343 ? 134.017 126.452 145.776 1.00 74.71  ? 343 LEU B CA  1 
ATOM   1849 C C   . LEU A 1 343 ? 133.370 127.717 146.323 1.00 74.71  ? 343 LEU B C   1 
ATOM   1850 O O   . LEU A 1 343 ? 132.141 127.790 146.406 1.00 74.71  ? 343 LEU B O   1 
ATOM   1851 C CB  . LEU A 1 343 ? 134.293 125.458 146.905 1.00 74.71  ? 343 LEU B CB  1 
ATOM   1852 C CG  . LEU A 1 343 ? 134.205 123.964 146.567 1.00 74.71  ? 343 LEU B CG  1 
ATOM   1853 C CD1 . LEU A 1 343 ? 132.783 123.599 146.160 1.00 74.71  ? 343 LEU B CD1 1 
ATOM   1854 C CD2 . LEU A 1 343 ? 135.195 123.541 145.491 1.00 74.71  ? 343 LEU B CD2 1 
ATOM   1855 N N   . GLY A 1 344 ? 134.168 128.723 146.688 1.00 74.61  ? 344 GLY B N   1 
ATOM   1856 C CA  . GLY A 1 344 ? 133.589 129.987 147.109 1.00 74.61  ? 344 GLY B CA  1 
ATOM   1857 C C   . GLY A 1 344 ? 132.810 130.666 146.000 1.00 74.61  ? 344 GLY B C   1 
ATOM   1858 O O   . GLY A 1 344 ? 131.703 131.161 146.219 1.00 74.61  ? 344 GLY B O   1 
ATOM   1859 N N   . ALA A 1 345 ? 133.376 130.691 144.790 1.00 83.74  ? 345 ALA B N   1 
ATOM   1860 C CA  . ALA A 1 345 ? 132.666 131.268 143.650 1.00 83.74  ? 345 ALA B CA  1 
ATOM   1861 C C   . ALA A 1 345 ? 131.413 130.468 143.316 1.00 83.74  ? 345 ALA B C   1 
ATOM   1862 O O   . ALA A 1 345 ? 130.362 131.044 143.002 1.00 83.74  ? 345 ALA B O   1 
ATOM   1863 C CB  . ALA A 1 345 ? 133.594 131.344 142.439 1.00 83.74  ? 345 ALA B CB  1 
ATOM   1864 N N   . VAL A 1 346 ? 131.506 129.137 143.379 1.00 85.25  ? 346 VAL B N   1 
ATOM   1865 C CA  . VAL A 1 346 ? 130.348 128.290 143.104 1.00 85.25  ? 346 VAL B CA  1 
ATOM   1866 C C   . VAL A 1 346 ? 129.239 128.558 144.115 1.00 85.25  ? 346 VAL B C   1 
ATOM   1867 O O   . VAL A 1 346 ? 128.063 128.675 143.752 1.00 85.25  ? 346 VAL B O   1 
ATOM   1868 C CB  . VAL A 1 346 ? 130.765 126.807 143.096 1.00 85.25  ? 346 VAL B CB  1 
ATOM   1869 C CG1 . VAL A 1 346 ? 129.555 125.904 143.274 1.00 85.25  ? 346 VAL B CG1 1 
ATOM   1870 C CG2 . VAL A 1 346 ? 131.501 126.470 141.806 1.00 85.25  ? 346 VAL B CG2 1 
ATOM   1871 N N   . ALA A 1 347 ? 129.598 128.671 145.395 1.00 87.79  ? 347 ALA B N   1 
ATOM   1872 C CA  . ALA A 1 347 ? 128.606 128.940 146.429 1.00 87.79  ? 347 ALA B CA  1 
ATOM   1873 C C   . ALA A 1 347 ? 128.022 130.340 146.293 1.00 87.79  ? 347 ALA B C   1 
ATOM   1874 O O   . ALA A 1 347 ? 126.835 130.551 146.565 1.00 87.79  ? 347 ALA B O   1 
ATOM   1875 C CB  . ALA A 1 347 ? 129.231 128.748 147.806 1.00 87.79  ? 347 ALA B CB  1 
ATOM   1876 N N   . VAL A 1 348 ? 128.839 131.311 145.878 1.00 90.10  ? 348 VAL B N   1 
ATOM   1877 C CA  . VAL A 1 348 ? 128.329 132.657 145.639 1.00 90.10  ? 348 VAL B CA  1 
ATOM   1878 C C   . VAL A 1 348 ? 127.301 132.642 144.516 1.00 90.10  ? 348 VAL B C   1 
ATOM   1879 O O   . VAL A 1 348 ? 126.259 133.303 144.597 1.00 90.10  ? 348 VAL B O   1 
ATOM   1880 C CB  . VAL A 1 348 ? 129.489 133.622 145.332 1.00 90.10  ? 348 VAL B CB  1 
ATOM   1881 N N   . PHE A 1 349 ? 127.583 131.893 143.447 1.00 95.70  ? 349 PHE B N   1 
ATOM   1882 C CA  . PHE A 1 349 ? 126.613 131.760 142.363 1.00 95.70  ? 349 PHE B CA  1 
ATOM   1883 C C   . PHE A 1 349 ? 125.351 131.043 142.830 1.00 95.70  ? 349 PHE B C   1 
ATOM   1884 O O   . PHE A 1 349 ? 124.236 131.434 142.464 1.00 95.70  ? 349 PHE B O   1 
ATOM   1885 C CB  . PHE A 1 349 ? 127.242 131.021 141.182 1.00 95.70  ? 349 PHE B CB  1 
ATOM   1886 N N   . ALA A 1 350 ? 125.505 129.997 143.642 1.00 95.62  ? 350 ALA B N   1 
ATOM   1887 C CA  . ALA A 1 350 ? 124.376 129.182 144.072 1.00 95.62  ? 350 ALA B CA  1 
ATOM   1888 C C   . ALA A 1 350 ? 123.558 129.821 145.185 1.00 95.62  ? 350 ALA B C   1 
ATOM   1889 O O   . ALA A 1 350 ? 122.458 129.338 145.473 1.00 95.62  ? 350 ALA B O   1 
ATOM   1890 C CB  . ALA A 1 350 ? 124.869 127.808 144.530 1.00 95.62  ? 350 ALA B CB  1 
ATOM   1891 N N   . VAL A 1 351 ? 124.070 130.873 145.826 1.00 91.57  ? 351 VAL B N   1 
ATOM   1892 C CA  . VAL A 1 351 ? 123.305 131.548 146.872 1.00 91.57  ? 351 VAL B CA  1 
ATOM   1893 C C   . VAL A 1 351 ? 122.027 132.145 146.299 1.00 91.57  ? 351 VAL B C   1 
ATOM   1894 O O   . VAL A 1 351 ? 120.950 132.035 146.896 1.00 91.57  ? 351 VAL B O   1 
ATOM   1895 C CB  . VAL A 1 351 ? 124.171 132.618 147.560 1.00 91.57  ? 351 VAL B CB  1 
ATOM   1896 N N   . GLY A 1 352 ? 122.123 132.782 145.136 1.00 96.71  ? 352 GLY B N   1 
ATOM   1897 C CA  . GLY A 1 352 ? 120.955 133.324 144.479 1.00 96.71  ? 352 GLY B CA  1 
ATOM   1898 C C   . GLY A 1 352 ? 120.120 132.323 143.717 1.00 96.71  ? 352 GLY B C   1 
ATOM   1899 O O   . GLY A 1 352 ? 119.059 132.681 143.201 1.00 96.71  ? 352 GLY B O   1 
ATOM   1900 N N   . TYR A 1 353 ? 120.568 131.069 143.631 1.00 95.62  ? 353 TYR B N   1 
ATOM   1901 C CA  . TYR A 1 353 ? 119.837 130.041 142.901 1.00 95.62  ? 353 TYR B CA  1 
ATOM   1902 C C   . TYR A 1 353 ? 118.710 129.419 143.715 1.00 95.62  ? 353 TYR B C   1 
ATOM   1903 O O   . TYR A 1 353 ? 117.931 128.635 143.161 1.00 95.62  ? 353 TYR B O   1 
ATOM   1904 C CB  . TYR A 1 353 ? 120.798 128.945 142.436 1.00 95.62  ? 353 TYR B CB  1 
ATOM   1905 N N   . ILE A 1 354 ? 118.603 129.739 145.001 1.00 86.29  ? 354 ILE B N   1 
ATOM   1906 C CA  . ILE A 1 354 ? 117.533 129.242 145.858 1.00 86.29  ? 354 ILE B CA  1 
ATOM   1907 C C   . ILE A 1 354 ? 116.699 130.435 146.300 1.00 86.29  ? 354 ILE B C   1 
ATOM   1908 O O   . ILE A 1 354 ? 117.220 131.363 146.930 1.00 86.29  ? 354 ILE B O   1 
ATOM   1909 C CB  . ILE A 1 354 ? 118.079 128.476 147.073 1.00 86.29  ? 354 ILE B CB  1 
ATOM   1910 N N   . LYS A 1 355 ? 115.409 130.410 145.975 1.00 76.06  ? 355 LYS B N   1 
ATOM   1911 C CA  . LYS A 1 355 ? 114.504 131.505 146.317 1.00 76.06  ? 355 LYS B CA  1 
ATOM   1912 C C   . LYS A 1 355 ? 114.048 131.322 147.759 1.00 76.06  ? 355 LYS B C   1 
ATOM   1913 O O   . LYS A 1 355 ? 113.166 130.511 148.048 1.00 76.06  ? 355 LYS B O   1 
ATOM   1914 C CB  . LYS A 1 355 ? 113.319 131.543 145.360 1.00 76.06  ? 355 LYS B CB  1 
ATOM   1915 N N   . ILE A 1 356 ? 114.658 132.074 148.672 1.00 66.61  ? 356 ILE B N   1 
ATOM   1916 C CA  . ILE A 1 356 ? 114.303 132.038 150.086 1.00 66.61  ? 356 ILE B CA  1 
ATOM   1917 C C   . ILE A 1 356 ? 114.221 133.468 150.599 1.00 66.61  ? 356 ILE B C   1 
ATOM   1918 O O   . ILE A 1 356 ? 115.136 134.267 150.374 1.00 66.61  ? 356 ILE B O   1 
ATOM   1919 C CB  . ILE A 1 356 ? 115.314 131.221 150.914 1.00 66.61  ? 356 ILE B CB  1 
ATOM   1920 N N   . SER A 1 357 ? 113.127 133.791 151.283 1.00 69.86  ? 357 SER B N   1 
ATOM   1921 C CA  . SER A 1 357 ? 112.961 135.121 151.849 1.00 69.86  ? 357 SER B CA  1 
ATOM   1922 C C   . SER A 1 357 ? 113.901 135.319 153.031 1.00 69.86  ? 357 SER B C   1 
ATOM   1923 O O   . SER A 1 357 ? 114.139 134.400 153.819 1.00 69.86  ? 357 SER B O   1 
ATOM   1924 C CB  . SER A 1 357 ? 111.513 135.335 152.288 1.00 69.86  ? 357 SER B CB  1 
ATOM   1925 N N   . TRP A 1 358 ? 114.442 136.533 153.148 1.00 67.18  ? 358 TRP B N   1 
ATOM   1926 C CA  . TRP A 1 358 ? 115.386 136.829 154.221 1.00 67.18  ? 358 TRP B CA  1 
ATOM   1927 C C   . TRP A 1 358 ? 114.686 137.016 155.562 1.00 67.18  ? 358 TRP B C   1 
ATOM   1928 O O   . TRP A 1 358 ? 115.204 136.589 156.602 1.00 67.18  ? 358 TRP B O   1 
ATOM   1929 C CB  . TRP A 1 358 ? 116.196 138.076 153.870 1.00 67.18  ? 358 TRP B CB  1 
ATOM   1930 N N   . SER A 1 359 ? 113.505 137.637 155.554 1.00 67.78  ? 359 SER B N   1 
ATOM   1931 C CA  . SER A 1 359 ? 112.822 138.011 156.786 1.00 67.78  ? 359 SER B CA  1 
ATOM   1932 C C   . SER A 1 359 ? 112.395 136.815 157.625 1.00 67.78  ? 359 SER B C   1 
ATOM   1933 O O   . SER A 1 359 ? 112.071 136.997 158.803 1.00 67.78  ? 359 SER B O   1 
ATOM   1934 C CB  . SER A 1 359 ? 111.598 138.870 156.462 1.00 67.78  ? 359 SER B CB  1 
ATOM   1935 N N   . THR A 1 360 ? 112.384 135.607 157.062 1.00 66.54  ? 360 THR B N   1 
ATOM   1936 C CA  . THR A 1 360 ? 111.949 134.443 157.826 1.00 66.54  ? 360 THR B CA  1 
ATOM   1937 C C   . THR A 1 360 ? 112.994 134.039 158.860 1.00 66.54  ? 360 THR B C   1 
ATOM   1938 O O   . THR A 1 360 ? 112.732 134.064 160.069 1.00 66.54  ? 360 THR B O   1 
ATOM   1939 C CB  . THR A 1 360 ? 111.646 133.279 156.881 1.00 66.54  ? 360 THR B CB  1 
ATOM   1940 N N   . TRP A 1 361 ? 114.193 133.664 158.403 1.00 63.67  ? 361 TRP B N   1 
ATOM   1941 C CA  . TRP A 1 361 ? 115.218 133.144 159.301 1.00 63.67  ? 361 TRP B CA  1 
ATOM   1942 C C   . TRP A 1 361 ? 116.611 133.657 158.948 1.00 63.67  ? 361 TRP B C   1 
ATOM   1943 O O   . TRP A 1 361 ? 117.597 132.926 159.102 1.00 63.67  ? 361 TRP B O   1 
ATOM   1944 C CB  . TRP A 1 361 ? 115.220 131.614 159.302 1.00 63.67  ? 361 TRP B CB  1 
ATOM   1945 N N   . GLY A 1 362 ? 116.716 134.898 158.463 1.00 63.38  ? 362 GLY B N   1 
ATOM   1946 C CA  . GLY A 1 362 ? 118.029 135.446 158.164 1.00 63.38  ? 362 GLY B CA  1 
ATOM   1947 C C   . GLY A 1 362 ? 118.926 135.517 159.384 1.00 63.38  ? 362 GLY B C   1 
ATOM   1948 O O   . GLY A 1 362 ? 120.113 135.186 159.314 1.00 63.38  ? 362 GLY B O   1 
ATOM   1949 N N   . GLU A 1 363 ? 118.370 135.942 160.521 1.00 61.18  ? 363 GLU B N   1 
ATOM   1950 C CA  . GLU A 1 363 ? 119.152 136.003 161.753 1.00 61.18  ? 363 GLU B CA  1 
ATOM   1951 C C   . GLU A 1 363 ? 119.600 134.614 162.192 1.00 61.18  ? 363 GLU B C   1 
ATOM   1952 O O   . GLU A 1 363 ? 120.736 134.434 162.648 1.00 61.18  ? 363 GLU B O   1 
ATOM   1953 C CB  . GLU A 1 363 ? 118.338 136.676 162.857 1.00 61.18  ? 363 GLU B CB  1 
ATOM   1954 N N   . MET A 1 364 ? 118.716 133.621 162.065 1.00 61.79  ? 364 MET B N   1 
ATOM   1955 C CA  . MET A 1 364 ? 119.075 132.255 162.433 1.00 61.79  ? 364 MET B CA  1 
ATOM   1956 C C   . MET A 1 364 ? 120.205 131.730 161.557 1.00 61.79  ? 364 MET B C   1 
ATOM   1957 O O   . MET A 1 364 ? 121.154 131.114 162.057 1.00 61.79  ? 364 MET B O   1 
ATOM   1958 C CB  . MET A 1 364 ? 117.849 131.348 162.330 1.00 61.79  ? 364 MET B CB  1 
ATOM   1959 C CG  . MET A 1 364 ? 116.761 131.668 163.343 1.00 61.79  ? 364 MET B CG  1 
ATOM   1960 S SD  . MET A 1 364 ? 115.287 130.648 163.160 1.00 61.79  ? 364 MET B SD  1 
ATOM   1961 C CE  . MET A 1 364 ? 115.904 129.063 163.720 1.00 61.79  ? 364 MET B CE  1 
ATOM   1962 N N   . THR A 1 365 ? 120.125 131.977 160.247 1.00 63.93  ? 365 THR B N   1 
ATOM   1963 C CA  . THR A 1 365 ? 121.187 131.535 159.348 1.00 63.93  ? 365 THR B CA  1 
ATOM   1964 C C   . THR A 1 365 ? 122.500 132.248 159.643 1.00 63.93  ? 365 THR B C   1 
ATOM   1965 O O   . THR A 1 365 ? 123.570 131.630 159.600 1.00 63.93  ? 365 THR B O   1 
ATOM   1966 C CB  . THR A 1 365 ? 120.779 131.753 157.894 1.00 63.93  ? 365 THR B CB  1 
ATOM   1967 O OG1 . THR A 1 365 ? 120.555 133.149 157.662 1.00 63.93  ? 365 THR B OG1 1 
ATOM   1968 C CG2 . THR A 1 365 ? 119.523 130.959 157.564 1.00 63.93  ? 365 THR B CG2 1 
ATOM   1969 N N   . LEU A 1 366 ? 122.444 133.549 159.935 1.00 63.56  ? 366 LEU B N   1 
ATOM   1970 C CA  . LEU A 1 366 ? 123.663 134.283 160.264 1.00 63.56  ? 366 LEU B CA  1 
ATOM   1971 C C   . LEU A 1 366 ? 124.305 133.744 161.537 1.00 63.56  ? 366 LEU B C   1 
ATOM   1972 O O   . LEU A 1 366 ? 125.528 133.556 161.597 1.00 63.56  ? 366 LEU B O   1 
ATOM   1973 C CB  . LEU A 1 366 ? 123.349 135.774 160.403 1.00 63.56  ? 366 LEU B CB  1 
ATOM   1974 C CG  . LEU A 1 366 ? 124.510 136.770 160.504 1.00 63.56  ? 366 LEU B CG  1 
ATOM   1975 C CD1 . LEU A 1 366 ? 124.186 138.035 159.723 1.00 63.56  ? 366 LEU B CD1 1 
ATOM   1976 C CD2 . LEU A 1 366 ? 124.826 137.112 161.957 1.00 63.56  ? 366 LEU B CD2 1 
ATOM   1977 N N   . SER A 1 367 ? 123.493 133.483 162.565 1.00 63.08  ? 367 SER B N   1 
ATOM   1978 C CA  . SER A 1 367 ? 124.024 132.944 163.812 1.00 63.08  ? 367 SER B CA  1 
ATOM   1979 C C   . SER A 1 367 ? 124.618 131.555 163.606 1.00 63.08  ? 367 SER B C   1 
ATOM   1980 O O   . SER A 1 367 ? 125.684 131.238 164.151 1.00 63.08  ? 367 SER B O   1 
ATOM   1981 C CB  . SER A 1 367 ? 122.924 132.910 164.872 1.00 63.08  ? 367 SER B CB  1 
ATOM   1982 O OG  . SER A 1 367 ? 121.818 132.146 164.426 1.00 63.08  ? 367 SER B OG  1 
ATOM   1983 N N   . LEU A 1 368 ? 123.942 130.713 162.818 1.00 61.64  ? 368 LEU B N   1 
ATOM   1984 C CA  . LEU A 1 368 ? 124.477 129.388 162.526 1.00 61.64  ? 368 LEU B CA  1 
ATOM   1985 C C   . LEU A 1 368 ? 125.796 129.480 161.773 1.00 61.64  ? 368 LEU B C   1 
ATOM   1986 O O   . LEU A 1 368 ? 126.732 128.725 162.055 1.00 61.64  ? 368 LEU B O   1 
ATOM   1987 C CB  . LEU A 1 368 ? 123.461 128.576 161.726 1.00 61.64  ? 368 LEU B CB  1 
ATOM   1988 C CG  . LEU A 1 368 ? 123.889 127.151 161.380 1.00 61.64  ? 368 LEU B CG  1 
ATOM   1989 C CD1 . LEU A 1 368 ? 124.030 126.314 162.639 1.00 61.64  ? 368 LEU B CD1 1 
ATOM   1990 C CD2 . LEU A 1 368 ? 122.903 126.514 160.414 1.00 61.64  ? 368 LEU B CD2 1 
ATOM   1991 N N   . PHE A 1 369 ? 125.887 130.400 160.809 1.00 54.26  ? 369 PHE B N   1 
ATOM   1992 C CA  . PHE A 1 369 ? 127.129 130.577 160.066 1.00 54.26  ? 369 PHE B CA  1 
ATOM   1993 C C   . PHE A 1 369 ? 128.259 131.023 160.983 1.00 54.26  ? 369 PHE B C   1 
ATOM   1994 O O   . PHE A 1 369 ? 129.390 130.533 160.871 1.00 54.26  ? 369 PHE B O   1 
ATOM   1995 C CB  . PHE A 1 369 ? 126.920 131.588 158.939 1.00 54.26  ? 369 PHE B CB  1 
ATOM   1996 N N   . SER A 1 370 ? 127.971 131.949 161.900 1.00 57.39  ? 370 SER B N   1 
ATOM   1997 C CA  . SER A 1 370 ? 128.991 132.388 162.848 1.00 57.39  ? 370 SER B CA  1 
ATOM   1998 C C   . SER A 1 370 ? 129.441 131.240 163.745 1.00 57.39  ? 370 SER B C   1 
ATOM   1999 O O   . SER A 1 370 ? 130.636 131.096 164.033 1.00 57.39  ? 370 SER B O   1 
ATOM   2000 C CB  . SER A 1 370 ? 128.463 133.551 163.688 1.00 57.39  ? 370 SER B CB  1 
ATOM   2001 O OG  . SER A 1 370 ? 129.390 133.910 164.698 1.00 57.39  ? 370 SER B OG  1 
ATOM   2002 N N   . LEU A 1 371 ? 128.496 130.411 164.195 1.00 54.88  ? 371 LEU B N   1 
ATOM   2003 C CA  . LEU A 1 371 ? 128.854 129.270 165.033 1.00 54.88  ? 371 LEU B CA  1 
ATOM   2004 C C   . LEU A 1 371 ? 129.713 128.265 164.270 1.00 54.88  ? 371 LEU B C   1 
ATOM   2005 O O   . LEU A 1 371 ? 130.682 127.724 164.817 1.00 54.88  ? 371 LEU B O   1 
ATOM   2006 C CB  . LEU A 1 371 ? 127.589 128.606 165.573 1.00 54.88  ? 371 LEU B CB  1 
ATOM   2007 C CG  . LEU A 1 371 ? 126.858 129.404 166.654 1.00 54.88  ? 371 LEU B CG  1 
ATOM   2008 C CD1 . LEU A 1 371 ? 125.453 128.863 166.871 1.00 54.88  ? 371 LEU B CD1 1 
ATOM   2009 C CD2 . LEU A 1 371 ? 127.648 129.395 167.954 1.00 54.88  ? 371 LEU B CD2 1 
ATOM   2010 N N   . LEU A 1 372 ? 129.373 128.003 163.006 1.00 52.32  ? 372 LEU B N   1 
ATOM   2011 C CA  . LEU A 1 372 ? 130.194 127.111 162.192 1.00 52.32  ? 372 LEU B CA  1 
ATOM   2012 C C   . LEU A 1 372 ? 131.592 127.678 161.990 1.00 52.32  ? 372 LEU B C   1 
ATOM   2013 O O   . LEU A 1 372 ? 132.580 126.936 162.019 1.00 52.32  ? 372 LEU B O   1 
ATOM   2014 C CB  . LEU A 1 372 ? 129.531 126.853 160.838 1.00 52.32  ? 372 LEU B CB  1 
ATOM   2015 C CG  . LEU A 1 372 ? 128.136 126.231 160.805 1.00 52.32  ? 372 LEU B CG  1 
ATOM   2016 C CD1 . LEU A 1 372 ? 127.699 125.992 159.369 1.00 52.32  ? 372 LEU B CD1 1 
ATOM   2017 C CD2 . LEU A 1 372 ? 128.108 124.936 161.603 1.00 52.32  ? 372 LEU B CD2 1 
ATOM   2018 N N   . ILE A 1 373 ? 131.694 128.989 161.773 1.00 52.31  ? 373 ILE B N   1 
ATOM   2019 C CA  . ILE A 1 373 ? 133.001 129.615 161.595 1.00 52.31  ? 373 ILE B CA  1 
ATOM   2020 C C   . ILE A 1 373 ? 133.833 129.482 162.865 1.00 52.31  ? 373 ILE B C   1 
ATOM   2021 O O   . ILE A 1 373 ? 135.033 129.170 162.816 1.00 52.31  ? 373 ILE B O   1 
ATOM   2022 C CB  . ILE A 1 373 ? 132.823 131.085 161.177 1.00 52.31  ? 373 ILE B CB  1 
ATOM   2023 C CG1 . ILE A 1 373 ? 132.348 131.168 159.727 1.00 52.31  ? 373 ILE B CG1 1 
ATOM   2024 C CG2 . ILE A 1 373 ? 134.117 131.845 161.346 1.00 52.31  ? 373 ILE B CG2 1 
ATOM   2025 C CD1 . ILE A 1 373 ? 131.691 132.481 159.374 1.00 52.31  ? 373 ILE B CD1 1 
ATOM   2026 N N   . ALA A 1 374 ? 133.208 129.714 164.022 1.00 53.59  ? 374 ALA B N   1 
ATOM   2027 C CA  . ALA A 1 374 ? 133.916 129.566 165.289 1.00 53.59  ? 374 ALA B CA  1 
ATOM   2028 C C   . ALA A 1 374 ? 134.372 128.129 165.501 1.00 53.59  ? 374 ALA B C   1 
ATOM   2029 O O   . ALA A 1 374 ? 135.492 127.885 165.967 1.00 53.59  ? 374 ALA B O   1 
ATOM   2030 C CB  . ALA A 1 374 ? 133.025 130.021 166.443 1.00 53.59  ? 374 ALA B CB  1 
ATOM   2031 N N   . ALA A 1 375 ? 133.516 127.163 165.164 1.00 51.94  ? 375 ALA B N   1 
ATOM   2032 C CA  . ALA A 1 375 ? 133.904 125.762 165.284 1.00 51.94  ? 375 ALA B CA  1 
ATOM   2033 C C   . ALA A 1 375 ? 135.076 125.437 164.368 1.00 51.94  ? 375 ALA B C   1 
ATOM   2034 O O   . ALA A 1 375 ? 135.996 124.713 164.761 1.00 51.94  ? 375 ALA B O   1 
ATOM   2035 C CB  . ALA A 1 375 ? 132.711 124.859 164.974 1.00 51.94  ? 375 ALA B CB  1 
ATOM   2036 N N   . ALA A 1 376 ? 135.060 125.969 163.144 1.00 46.67  ? 376 ALA B N   1 
ATOM   2037 C CA  . ALA A 1 376 ? 136.141 125.709 162.200 1.00 46.67  ? 376 ALA B CA  1 
ATOM   2038 C C   . ALA A 1 376 ? 137.465 126.263 162.708 1.00 46.67  ? 376 ALA B C   1 
ATOM   2039 O O   . ALA A 1 376 ? 138.502 125.591 162.635 1.00 46.67  ? 376 ALA B O   1 
ATOM   2040 C CB  . ALA A 1 376 ? 135.796 126.305 160.837 1.00 46.67  ? 376 ALA B CB  1 
ATOM   2041 N N   . VAL A 1 377 ? 137.456 127.496 163.222 1.00 45.77  ? 377 VAL B N   1 
ATOM   2042 C CA  . VAL A 1 377 ? 138.709 128.078 163.698 1.00 45.77  ? 377 VAL B CA  1 
ATOM   2043 C C   . VAL A 1 377 ? 139.191 127.359 164.955 1.00 45.77  ? 377 VAL B C   1 
ATOM   2044 O O   . VAL A 1 377 ? 140.396 127.140 165.137 1.00 45.77  ? 377 VAL B O   1 
ATOM   2045 C CB  . VAL A 1 377 ? 138.584 129.601 163.905 1.00 45.77  ? 377 VAL B CB  1 
ATOM   2046 C CG1 . VAL A 1 377 ? 138.256 130.289 162.589 1.00 45.77  ? 377 VAL B CG1 1 
ATOM   2047 C CG2 . VAL A 1 377 ? 137.553 129.945 164.954 1.00 45.77  ? 377 VAL B CG2 1 
ATOM   2048 N N   . TYR A 1 378 ? 138.268 126.943 165.827 1.00 44.48  ? 378 TYR B N   1 
ATOM   2049 C CA  . TYR A 1 378 ? 138.686 126.203 167.013 1.00 44.48  ? 378 TYR B CA  1 
ATOM   2050 C C   . TYR A 1 378 ? 139.243 124.833 166.640 1.00 44.48  ? 378 TYR B C   1 
ATOM   2051 O O   . TYR A 1 378 ? 140.192 124.356 167.275 1.00 44.48  ? 378 TYR B O   1 
ATOM   2052 C CB  . TYR A 1 378 ? 137.513 126.069 167.982 1.00 44.48  ? 378 TYR B CB  1 
ATOM   2053 C CG  . TYR A 1 378 ? 137.906 126.056 169.444 1.00 44.48  ? 378 TYR B CG  1 
ATOM   2054 C CD1 . TYR A 1 378 ? 138.207 127.236 170.108 1.00 44.48  ? 378 TYR B CD1 1 
ATOM   2055 C CD2 . TYR A 1 378 ? 137.959 124.871 170.162 1.00 44.48  ? 378 TYR B CD2 1 
ATOM   2056 C CE1 . TYR A 1 378 ? 138.556 127.237 171.439 1.00 44.48  ? 378 TYR B CE1 1 
ATOM   2057 C CE2 . TYR A 1 378 ? 138.308 124.864 171.498 1.00 44.48  ? 378 TYR B CE2 1 
ATOM   2058 C CZ  . TYR A 1 378 ? 138.605 126.051 172.129 1.00 44.48  ? 378 TYR B CZ  1 
ATOM   2059 O OH  . TYR A 1 378 ? 138.954 126.050 173.458 1.00 44.48  ? 378 TYR B OH  1 
ATOM   2060 N N   . ILE A 1 379 ? 138.680 124.200 165.609 1.00 44.76  ? 379 ILE B N   1 
ATOM   2061 C CA  . ILE A 1 379 ? 139.203 122.923 165.133 1.00 44.76  ? 379 ILE B CA  1 
ATOM   2062 C C   . ILE A 1 379 ? 140.606 123.098 164.569 1.00 44.76  ? 379 ILE B C   1 
ATOM   2063 O O   . ILE A 1 379 ? 141.536 122.379 164.951 1.00 44.76  ? 379 ILE B O   1 
ATOM   2064 C CB  . ILE A 1 379 ? 138.248 122.303 164.095 1.00 44.76  ? 379 ILE B CB  1 
ATOM   2065 C CG1 . ILE A 1 379 ? 137.105 121.565 164.797 1.00 44.76  ? 379 ILE B CG1 1 
ATOM   2066 C CG2 . ILE A 1 379 ? 138.994 121.362 163.157 1.00 44.76  ? 379 ILE B CG2 1 
ATOM   2067 C CD1 . ILE A 1 379 ? 136.015 121.091 163.860 1.00 44.76  ? 379 ILE B CD1 1 
ATOM   2068 N N   . MET A 1 380 ? 140.792 124.073 163.673 1.00 44.42  ? 380 MET B N   1 
ATOM   2069 C CA  . MET A 1 380 ? 142.122 124.273 163.110 1.00 44.42  ? 380 MET B CA  1 
ATOM   2070 C C   . MET A 1 380 ? 143.123 124.679 164.180 1.00 44.42  ? 380 MET B C   1 
ATOM   2071 O O   . MET A 1 380 ? 144.326 124.457 164.006 1.00 44.42  ? 380 MET B O   1 
ATOM   2072 C CB  . MET A 1 380 ? 142.103 125.314 161.986 1.00 44.42  ? 380 MET B CB  1 
ATOM   2073 C CG  . MET A 1 380 ? 141.736 126.715 162.415 1.00 44.42  ? 380 MET B CG  1 
ATOM   2074 S SD  . MET A 1 380 ? 141.629 127.880 161.045 1.00 44.42  ? 380 MET B SD  1 
ATOM   2075 C CE  . MET A 1 380 ? 140.100 127.360 160.274 1.00 44.42  ? 380 MET B CE  1 
ATOM   2076 N N   . ASP A 1 381 ? 142.654 125.263 165.285 1.00 42.70  ? 381 ASP B N   1 
ATOM   2077 C CA  . ASP A 1 381 ? 143.517 125.422 166.450 1.00 42.70  ? 381 ASP B CA  1 
ATOM   2078 C C   . ASP A 1 381 ? 143.821 124.080 167.106 1.00 42.70  ? 381 ASP B C   1 
ATOM   2079 O O   . ASP A 1 381 ? 144.943 123.853 167.574 1.00 42.70  ? 381 ASP B O   1 
ATOM   2080 C CB  . ASP A 1 381 ? 142.868 126.365 167.460 1.00 42.70  ? 381 ASP B CB  1 
ATOM   2081 C CG  . ASP A 1 381 ? 143.865 126.946 168.448 1.00 42.70  ? 381 ASP B CG  1 
ATOM   2082 O OD1 . ASP A 1 381 ? 144.982 126.405 168.580 1.00 42.70  ? 381 ASP B OD1 1 
ATOM   2083 O OD2 . ASP A 1 381 ? 143.521 127.941 169.114 1.00 42.70  ? 381 ASP B OD2 1 
ATOM   2084 N N   . THR A 1 382 ? 142.846 123.170 167.139 1.00 43.07  ? 382 THR B N   1 
ATOM   2085 C CA  . THR A 1 382 ? 142.935 122.034 168.051 1.00 43.07  ? 382 THR B CA  1 
ATOM   2086 C C   . THR A 1 382 ? 142.940 120.691 167.318 1.00 43.07  ? 382 THR B C   1 
ATOM   2087 O O   . THR A 1 382 ? 142.183 119.780 167.669 1.00 43.07  ? 382 THR B O   1 
ATOM   2088 C CB  . THR A 1 382 ? 141.782 122.102 169.060 1.00 43.07  ? 382 THR B CB  1 
ATOM   2089 O OG1 . THR A 1 382 ? 141.614 123.458 169.486 1.00 43.07  ? 382 THR B OG1 1 
ATOM   2090 C CG2 . THR A 1 382 ? 142.102 121.276 170.303 1.00 43.07  ? 382 THR B CG2 1 
ATOM   2091 N N   . VAL A 1 383 ? 143.765 120.557 166.276 1.00 43.49  ? 383 VAL B N   1 
ATOM   2092 C CA  . VAL A 1 383 ? 144.000 119.272 165.629 1.00 43.49  ? 383 VAL B CA  1 
ATOM   2093 C C   . VAL A 1 383 ? 145.468 118.864 165.669 1.00 43.49  ? 383 VAL B C   1 
ATOM   2094 O O   . VAL A 1 383 ? 145.782 117.707 165.968 1.00 43.49  ? 383 VAL B O   1 
ATOM   2095 C CB  . VAL A 1 383 ? 143.460 119.244 164.180 1.00 43.49  ? 383 VAL B CB  1 
ATOM   2096 C CG1 . VAL A 1 383 ? 141.962 119.436 164.177 1.00 43.49  ? 383 VAL B CG1 1 
ATOM   2097 C CG2 . VAL A 1 383 ? 144.106 120.330 163.332 1.00 43.49  ? 383 VAL B CG2 1 
ATOM   2098 N N   . GLY A 1 384 ? 146.384 119.783 165.375 1.00 47.50  ? 384 GLY B N   1 
ATOM   2099 C CA  . GLY A 1 384 ? 147.789 119.429 165.367 1.00 47.50  ? 384 GLY B CA  1 
ATOM   2100 C C   . GLY A 1 384 ? 148.232 118.579 164.199 1.00 47.50  ? 384 GLY B C   1 
ATOM   2101 O O   . GLY A 1 384 ? 149.342 118.040 164.233 1.00 47.50  ? 384 GLY B O   1 
ATOM   2102 N N   . ASN A 1 385 ? 147.402 118.438 163.172 1.00 47.73  ? 385 ASN B N   1 
ATOM   2103 C CA  . ASN A 1 385 ? 147.708 117.643 161.992 1.00 47.73  ? 385 ASN B CA  1 
ATOM   2104 C C   . ASN A 1 385 ? 147.704 118.550 160.759 1.00 47.73  ? 385 ASN B C   1 
ATOM   2105 O O   . ASN A 1 385 ? 147.652 119.779 160.865 1.00 47.73  ? 385 ASN B O   1 
ATOM   2106 C CB  . ASN A 1 385 ? 146.723 116.479 161.861 1.00 47.73  ? 385 ASN B CB  1 
ATOM   2107 C CG  . ASN A 1 385 ? 147.318 115.289 161.141 1.00 47.73  ? 385 ASN B CG  1 
ATOM   2108 O OD1 . ASN A 1 385 ? 148.161 115.442 160.259 1.00 47.73  ? 385 ASN B OD1 1 
ATOM   2109 N ND2 . ASN A 1 385 ? 146.879 114.093 161.512 1.00 47.73  ? 385 ASN B ND2 1 
ATOM   2110 N N   . ILE A 1 386 ? 147.766 117.935 159.581 1.00 44.08  ? 386 ILE B N   1 
ATOM   2111 C CA  . ILE A 1 386 ? 148.014 118.648 158.330 1.00 44.08  ? 386 ILE B CA  1 
ATOM   2112 C C   . ILE A 1 386 ? 146.790 118.605 157.399 1.00 44.08  ? 386 ILE B C   1 
ATOM   2113 O O   . ILE A 1 386 ? 146.228 119.647 157.046 1.00 44.08  ? 386 ILE B O   1 
ATOM   2114 C CB  . ILE A 1 386 ? 149.291 118.109 157.639 1.00 44.08  ? 386 ILE B CB  1 
ATOM   2115 C CG1 . ILE A 1 386 ? 149.612 118.868 156.352 1.00 44.08  ? 386 ILE B CG1 1 
ATOM   2116 C CG2 . ILE A 1 386 ? 149.268 116.582 157.453 1.00 44.08  ? 386 ILE B CG2 1 
ATOM   2117 C CD1 . ILE A 1 386 ? 150.239 120.224 156.599 1.00 44.08  ? 386 ILE B CD1 1 
ATOM   2118 N N   . TRP A 1 387 ? 146.345 117.404 157.019 1.00 45.22  ? 387 TRP B N   1 
ATOM   2119 C CA  . TRP A 1 387 ? 145.219 117.295 156.096 1.00 45.22  ? 387 TRP B CA  1 
ATOM   2120 C C   . TRP A 1 387 ? 143.931 117.805 156.728 1.00 45.22  ? 387 TRP B C   1 
ATOM   2121 O O   . TRP A 1 387 ? 143.138 118.492 156.071 1.00 45.22  ? 387 TRP B O   1 
ATOM   2122 C CB  . TRP A 1 387 ? 145.056 115.847 155.641 1.00 45.22  ? 387 TRP B CB  1 
ATOM   2123 C CG  . TRP A 1 387 ? 143.925 115.637 154.683 1.00 45.22  ? 387 TRP B CG  1 
ATOM   2124 C CD1 . TRP A 1 387 ? 143.517 116.484 153.693 1.00 45.22  ? 387 TRP B CD1 1 
ATOM   2125 C CD2 . TRP A 1 387 ? 143.054 114.502 154.623 1.00 45.22  ? 387 TRP B CD2 1 
ATOM   2126 N NE1 . TRP A 1 387 ? 142.446 115.945 153.022 1.00 45.22  ? 387 TRP B NE1 1 
ATOM   2127 C CE2 . TRP A 1 387 ? 142.143 114.729 153.574 1.00 45.22  ? 387 TRP B CE2 1 
ATOM   2128 C CE3 . TRP A 1 387 ? 142.958 113.315 155.356 1.00 45.22  ? 387 TRP B CE3 1 
ATOM   2129 C CZ2 . TRP A 1 387 ? 141.150 113.814 153.239 1.00 45.22  ? 387 TRP B CZ2 1 
ATOM   2130 C CZ3 . TRP A 1 387 ? 141.972 112.409 155.023 1.00 45.22  ? 387 TRP B CZ3 1 
ATOM   2131 C CH2 . TRP A 1 387 ? 141.081 112.662 153.974 1.00 45.22  ? 387 TRP B CH2 1 
ATOM   2132 N N   . VAL A 1 388 ? 143.707 117.482 158.003 1.00 47.39  ? 388 VAL B N   1 
ATOM   2133 C CA  . VAL A 1 388 ? 142.491 117.932 158.669 1.00 47.39  ? 388 VAL B CA  1 
ATOM   2134 C C   . VAL A 1 388 ? 142.497 119.446 158.835 1.00 47.39  ? 388 VAL B C   1 
ATOM   2135 O O   . VAL A 1 388 ? 141.443 120.087 158.748 1.00 47.39  ? 388 VAL B O   1 
ATOM   2136 C CB  . VAL A 1 388 ? 142.309 117.199 160.013 1.00 47.39  ? 388 VAL B CB  1 
ATOM   2137 C CG1 . VAL A 1 388 ? 143.464 117.482 160.947 1.00 47.39  ? 388 VAL B CG1 1 
ATOM   2138 C CG2 . VAL A 1 388 ? 140.983 117.575 160.659 1.00 47.39  ? 388 VAL B CG2 1 
ATOM   2139 N N   . CYS A 1 389 ? 143.666 120.052 159.062 1.00 45.92  ? 389 CYS B N   1 
ATOM   2140 C CA  . CYS A 1 389 ? 143.696 121.504 159.187 1.00 45.92  ? 389 CYS B CA  1 
ATOM   2141 C C   . CYS A 1 389 ? 143.442 122.170 157.839 1.00 45.92  ? 389 CYS B C   1 
ATOM   2142 O O   . CYS A 1 389 ? 142.750 123.194 157.775 1.00 45.92  ? 389 CYS B O   1 
ATOM   2143 C CB  . CYS A 1 389 ? 145.014 121.976 159.808 1.00 45.92  ? 389 CYS B CB  1 
ATOM   2144 S SG  . CYS A 1 389 ? 146.454 122.068 158.730 1.00 45.92  ? 389 CYS B SG  1 
ATOM   2145 N N   . TYR A 1 390 ? 143.949 121.585 156.744 1.00 46.61  ? 390 TYR B N   1 
ATOM   2146 C CA  . TYR A 1 390 ? 143.545 122.087 155.429 1.00 46.61  ? 390 TYR B CA  1 
ATOM   2147 C C   . TYR A 1 390 ? 142.041 121.962 155.218 1.00 46.61  ? 390 TYR B C   1 
ATOM   2148 O O   . TYR A 1 390 ? 141.408 122.874 154.672 1.00 46.61  ? 390 TYR B O   1 
ATOM   2149 C CB  . TYR A 1 390 ? 144.270 121.367 154.292 1.00 46.61  ? 390 TYR B CB  1 
ATOM   2150 C CG  . TYR A 1 390 ? 145.753 121.603 154.192 1.00 46.61  ? 390 TYR B CG  1 
ATOM   2151 C CD1 . TYR A 1 390 ? 146.259 122.883 154.016 1.00 46.61  ? 390 TYR B CD1 1 
ATOM   2152 C CD2 . TYR A 1 390 ? 146.640 120.541 154.165 1.00 46.61  ? 390 TYR B CD2 1 
ATOM   2153 C CE1 . TYR A 1 390 ? 147.614 123.102 153.893 1.00 46.61  ? 390 TYR B CE1 1 
ATOM   2154 C CE2 . TYR A 1 390 ? 147.990 120.750 154.032 1.00 46.61  ? 390 TYR B CE2 1 
ATOM   2155 C CZ  . TYR A 1 390 ? 148.476 122.029 153.901 1.00 46.61  ? 390 TYR B CZ  1 
ATOM   2156 O OH  . TYR A 1 390 ? 149.831 122.228 153.773 1.00 46.61  ? 390 TYR B OH  1 
ATOM   2157 N N   . ALA A 1 391 ? 141.455 120.830 155.614 1.00 49.64  ? 391 ALA B N   1 
ATOM   2158 C CA  . ALA A 1 391 ? 140.020 120.636 155.417 1.00 49.64  ? 391 ALA B CA  1 
ATOM   2159 C C   . ALA A 1 391 ? 139.211 121.659 156.205 1.00 49.64  ? 391 ALA B C   1 
ATOM   2160 O O   . ALA A 1 391 ? 138.242 122.236 155.688 1.00 49.64  ? 391 ALA B O   1 
ATOM   2161 C CB  . ALA A 1 391 ? 139.623 119.217 155.819 1.00 49.64  ? 391 ALA B CB  1 
ATOM   2162 N N   . SER A 1 392 ? 139.597 121.896 157.459 1.00 46.97  ? 392 SER B N   1 
ATOM   2163 C CA  . SER A 1 392 ? 138.919 122.898 158.270 1.00 46.97  ? 392 SER B CA  1 
ATOM   2164 C C   . SER A 1 392 ? 139.070 124.283 157.662 1.00 46.97  ? 392 SER B C   1 
ATOM   2165 O O   . SER A 1 392 ? 138.122 125.075 157.663 1.00 46.97  ? 392 SER B O   1 
ATOM   2166 C CB  . SER A 1 392 ? 139.468 122.876 159.694 1.00 46.97  ? 392 SER B CB  1 
ATOM   2167 O OG  . SER A 1 392 ? 140.880 122.985 159.684 1.00 46.97  ? 392 SER B OG  1 
ATOM   2168 N N   . TYR A 1 393 ? 140.257 124.591 157.132 1.00 43.71  ? 393 TYR B N   1 
ATOM   2169 C CA  . TYR A 1 393 ? 140.451 125.869 156.455 1.00 43.71  ? 393 TYR B CA  1 
ATOM   2170 C C   . TYR A 1 393 ? 139.530 126.005 155.251 1.00 43.71  ? 393 TYR B C   1 
ATOM   2171 O O   . TYR A 1 393 ? 138.937 127.067 155.034 1.00 43.71  ? 393 TYR B O   1 
ATOM   2172 C CB  . TYR A 1 393 ? 141.911 126.019 156.034 1.00 43.71  ? 393 TYR B CB  1 
ATOM   2173 C CG  . TYR A 1 393 ? 142.216 127.333 155.356 1.00 43.71  ? 393 TYR B CG  1 
ATOM   2174 C CD1 . TYR A 1 393 ? 142.325 128.507 156.089 1.00 43.71  ? 393 TYR B CD1 1 
ATOM   2175 C CD2 . TYR A 1 393 ? 142.407 127.397 153.983 1.00 43.71  ? 393 TYR B CD2 1 
ATOM   2176 C CE1 . TYR A 1 393 ? 142.604 129.710 155.471 1.00 43.71  ? 393 TYR B CE1 1 
ATOM   2177 C CE2 . TYR A 1 393 ? 142.691 128.593 153.359 1.00 43.71  ? 393 TYR B CE2 1 
ATOM   2178 C CZ  . TYR A 1 393 ? 142.788 129.747 154.107 1.00 43.71  ? 393 TYR B CZ  1 
ATOM   2179 O OH  . TYR A 1 393 ? 143.067 130.942 153.487 1.00 43.71  ? 393 TYR B OH  1 
ATOM   2180 N N   . VAL A 1 394 ? 139.395 124.939 154.460 1.00 44.03  ? 394 VAL B N   1 
ATOM   2181 C CA  . VAL A 1 394 ? 138.529 124.982 153.283 1.00 44.03  ? 394 VAL B CA  1 
ATOM   2182 C C   . VAL A 1 394 ? 137.084 125.241 153.693 1.00 44.03  ? 394 VAL B C   1 
ATOM   2183 O O   . VAL A 1 394 ? 136.392 126.088 153.111 1.00 44.03  ? 394 VAL B O   1 
ATOM   2184 C CB  . VAL A 1 394 ? 138.654 123.676 152.478 1.00 44.03  ? 394 VAL B CB  1 
ATOM   2185 C CG1 . VAL A 1 394 ? 137.585 123.614 151.397 1.00 44.03  ? 394 VAL B CG1 1 
ATOM   2186 C CG2 . VAL A 1 394 ? 140.032 123.559 151.868 1.00 44.03  ? 394 VAL B CG2 1 
ATOM   2187 N N   . VAL A 1 395 ? 136.609 124.511 154.705 1.00 47.10  ? 395 VAL B N   1 
ATOM   2188 C CA  . VAL A 1 395 ? 135.232 124.690 155.158 1.00 47.10  ? 395 VAL B CA  1 
ATOM   2189 C C   . VAL A 1 395 ? 135.031 126.098 155.704 1.00 47.10  ? 395 VAL B C   1 
ATOM   2190 O O   . VAL A 1 395 ? 133.984 126.723 155.486 1.00 47.10  ? 395 VAL B O   1 
ATOM   2191 C CB  . VAL A 1 395 ? 134.863 123.615 156.196 1.00 47.10  ? 395 VAL B CB  1 
ATOM   2192 C CG1 . VAL A 1 395 ? 133.429 123.793 156.662 1.00 47.10  ? 395 VAL B CG1 1 
ATOM   2193 C CG2 . VAL A 1 395 ? 135.049 122.232 155.603 1.00 47.10  ? 395 VAL B CG2 1 
ATOM   2194 N N   . PHE A 1 396 ? 136.034 126.624 156.412 1.00 51.46  ? 396 PHE B N   1 
ATOM   2195 C CA  . PHE A 1 396 ? 135.941 127.983 156.928 1.00 51.46  ? 396 PHE B CA  1 
ATOM   2196 C C   . PHE A 1 396 ? 135.835 128.996 155.796 1.00 51.46  ? 396 PHE B C   1 
ATOM   2197 O O   . PHE A 1 396 ? 135.019 129.923 155.861 1.00 51.46  ? 396 PHE B O   1 
ATOM   2198 C CB  . PHE A 1 396 ? 137.147 128.295 157.811 1.00 51.46  ? 396 PHE B CB  1 
ATOM   2199 C CG  . PHE A 1 396 ? 137.378 129.762 158.016 1.00 51.46  ? 396 PHE B CG  1 
ATOM   2200 C CD1 . PHE A 1 396 ? 136.433 130.544 158.659 1.00 51.46  ? 396 PHE B CD1 1 
ATOM   2201 C CD2 . PHE A 1 396 ? 138.534 130.363 157.553 1.00 51.46  ? 396 PHE B CD2 1 
ATOM   2202 C CE1 . PHE A 1 396 ? 136.640 131.895 158.841 1.00 51.46  ? 396 PHE B CE1 1 
ATOM   2203 C CE2 . PHE A 1 396 ? 138.745 131.714 157.732 1.00 51.46  ? 396 PHE B CE2 1 
ATOM   2204 C CZ  . PHE A 1 396 ? 137.797 132.481 158.378 1.00 51.46  ? 396 PHE B CZ  1 
ATOM   2205 N N   . ARG A 1 397 ? 136.648 128.832 154.749 1.00 50.98  ? 397 ARG B N   1 
ATOM   2206 C CA  . ARG A 1 397 ? 136.547 129.725 153.598 1.00 50.98  ? 397 ARG B CA  1 
ATOM   2207 C C   . ARG A 1 397 ? 135.156 129.660 152.986 1.00 50.98  ? 397 ARG B C   1 
ATOM   2208 O O   . ARG A 1 397 ? 134.560 130.696 152.666 1.00 50.98  ? 397 ARG B O   1 
ATOM   2209 C CB  . ARG A 1 397 ? 137.591 129.370 152.538 1.00 50.98  ? 397 ARG B CB  1 
ATOM   2210 C CG  . ARG A 1 397 ? 139.034 129.317 153.008 1.00 50.98  ? 397 ARG B CG  1 
ATOM   2211 C CD  . ARG A 1 397 ? 139.672 130.686 153.058 1.00 50.98  ? 397 ARG B CD  1 
ATOM   2212 N NE  . ARG A 1 397 ? 139.696 131.357 151.763 1.00 50.98  ? 397 ARG B NE  1 
ATOM   2213 C CZ  . ARG A 1 397 ? 140.543 131.077 150.781 1.00 50.98  ? 397 ARG B CZ  1 
ATOM   2214 N NH1 . ARG A 1 397 ? 141.454 130.126 150.903 1.00 50.98  ? 397 ARG B NH1 1 
ATOM   2215 N NH2 . ARG A 1 397 ? 140.476 131.773 149.649 1.00 50.98  ? 397 ARG B NH2 1 
ATOM   2216 N N   . ILE A 1 398 ? 134.621 128.449 152.826 1.00 53.26  ? 398 ILE B N   1 
ATOM   2217 C CA  . ILE A 1 398 ? 133.315 128.293 152.189 1.00 53.26  ? 398 ILE B CA  1 
ATOM   2218 C C   . ILE A 1 398 ? 132.237 129.004 153.000 1.00 53.26  ? 398 ILE B C   1 
ATOM   2219 O O   . ILE A 1 398 ? 131.427 129.767 152.455 1.00 53.26  ? 398 ILE B O   1 
ATOM   2220 C CB  . ILE A 1 398 ? 132.993 126.802 151.993 1.00 53.26  ? 398 ILE B CB  1 
ATOM   2221 C CG1 . ILE A 1 398 ? 134.012 126.170 151.044 1.00 53.26  ? 398 ILE B CG1 1 
ATOM   2222 C CG2 . ILE A 1 398 ? 131.585 126.621 151.457 1.00 53.26  ? 398 ILE B CG2 1 
ATOM   2223 C CD1 . ILE A 1 398 ? 133.943 124.666 150.986 1.00 53.26  ? 398 ILE B CD1 1 
ATOM   2224 N N   . ILE A 1 399 ? 132.230 128.791 154.317 1.00 54.00  ? 399 ILE B N   1 
ATOM   2225 C CA  . ILE A 1 399 ? 131.221 129.434 155.156 1.00 54.00  ? 399 ILE B CA  1 
ATOM   2226 C C   . ILE A 1 399 ? 131.400 130.948 155.142 1.00 54.00  ? 399 ILE B C   1 
ATOM   2227 O O   . ILE A 1 399 ? 130.420 131.706 155.189 1.00 54.00  ? 399 ILE B O   1 
ATOM   2228 C CB  . ILE A 1 399 ? 131.268 128.865 156.584 1.00 54.00  ? 399 ILE B CB  1 
ATOM   2229 C CG1 . ILE A 1 399 ? 131.145 127.343 156.555 1.00 54.00  ? 399 ILE B CG1 1 
ATOM   2230 C CG2 . ILE A 1 399 ? 130.140 129.440 157.421 1.00 54.00  ? 399 ILE B CG2 1 
ATOM   2231 C CD1 . ILE A 1 399 ? 131.593 126.675 157.834 1.00 54.00  ? 399 ILE B CD1 1 
ATOM   2232 N N   . TYR A 1 400 ? 132.652 131.412 155.070 1.00 54.74  ? 400 TYR B N   1 
ATOM   2233 C CA  . TYR A 1 400 ? 132.919 132.843 154.984 1.00 54.74  ? 400 TYR B CA  1 
ATOM   2234 C C   . TYR A 1 400 ? 132.268 133.433 153.740 1.00 54.74  ? 400 TYR B C   1 
ATOM   2235 O O   . TYR A 1 400 ? 131.605 134.478 153.803 1.00 54.74  ? 400 TYR B O   1 
ATOM   2236 C CB  . TYR A 1 400 ? 134.427 133.079 154.935 1.00 54.74  ? 400 TYR B CB  1 
ATOM   2237 C CG  . TYR A 1 400 ? 134.837 134.513 154.690 1.00 54.74  ? 400 TYR B CG  1 
ATOM   2238 C CD1 . TYR A 1 400 ? 134.259 135.554 155.399 1.00 54.74  ? 400 TYR B CD1 1 
ATOM   2239 C CD2 . TYR A 1 400 ? 135.730 134.832 153.681 1.00 54.74  ? 400 TYR B CD2 1 
ATOM   2240 C CE1 . TYR A 1 400 ? 134.638 136.861 155.176 1.00 54.74  ? 400 TYR B CE1 1 
ATOM   2241 C CE2 . TYR A 1 400 ? 136.098 136.141 153.436 1.00 54.74  ? 400 TYR B CE2 1 
ATOM   2242 C CZ  . TYR A 1 400 ? 135.542 137.151 154.182 1.00 54.74  ? 400 TYR B CZ  1 
ATOM   2243 O OH  . TYR A 1 400 ? 135.901 138.457 153.940 1.00 54.74  ? 400 TYR B OH  1 
ATOM   2244 N N   . MET A 1 401 ? 132.459 132.771 152.591 1.00 55.31  ? 401 MET B N   1 
ATOM   2245 C CA  . MET A 1 401 ? 131.836 133.245 151.356 1.00 55.31  ? 401 MET B CA  1 
ATOM   2246 C C   . MET A 1 401 ? 130.316 133.217 151.437 1.00 55.31  ? 401 MET B C   1 
ATOM   2247 O O   . MET A 1 401 ? 129.664 134.163 150.989 1.00 55.31  ? 401 MET B O   1 
ATOM   2248 C CB  . MET A 1 401 ? 132.316 132.455 150.136 1.00 55.31  ? 401 MET B CB  1 
ATOM   2249 C CG  . MET A 1 401 ? 133.787 132.084 150.082 1.00 55.31  ? 401 MET B CG  1 
ATOM   2250 S SD  . MET A 1 401 ? 134.876 133.454 150.528 1.00 55.31  ? 401 MET B SD  1 
ATOM   2251 C CE  . MET A 1 401 ? 136.369 132.591 151.013 1.00 55.31  ? 401 MET B CE  1 
ATOM   2252 N N   . LEU A 1 402 ? 129.727 132.152 151.992 1.00 59.42  ? 402 LEU B N   1 
ATOM   2253 C CA  . LEU A 1 402 ? 128.269 132.138 152.142 1.00 59.42  ? 402 LEU B CA  1 
ATOM   2254 C C   . LEU A 1 402 ? 127.783 133.330 152.958 1.00 59.42  ? 402 LEU B C   1 
ATOM   2255 O O   . LEU A 1 402 ? 126.846 134.038 152.556 1.00 59.42  ? 402 LEU B O   1 
ATOM   2256 C CB  . LEU A 1 402 ? 127.779 130.835 152.781 1.00 59.42  ? 402 LEU B CB  1 
ATOM   2257 C CG  . LEU A 1 402 ? 127.530 129.550 151.980 1.00 59.42  ? 402 LEU B CG  1 
ATOM   2258 C CD1 . LEU A 1 402 ? 126.400 129.780 150.984 1.00 59.42  ? 402 LEU B CD1 1 
ATOM   2259 C CD2 . LEU A 1 402 ? 128.746 129.018 151.279 1.00 59.42  ? 402 LEU B CD2 1 
ATOM   2260 N N   . LEU A 1 403 ? 128.415 133.571 154.109 1.00 59.43  ? 403 LEU B N   1 
ATOM   2261 C CA  . LEU A 1 403 ? 127.944 134.628 154.996 1.00 59.43  ? 403 LEU B CA  1 
ATOM   2262 C C   . LEU A 1 403 ? 128.093 135.998 154.345 1.00 59.43  ? 403 LEU B C   1 
ATOM   2263 O O   . LEU A 1 403 ? 127.152 136.803 154.341 1.00 59.43  ? 403 LEU B O   1 
ATOM   2264 C CB  . LEU A 1 403 ? 128.694 134.570 156.325 1.00 59.43  ? 403 LEU B CB  1 
ATOM   2265 C CG  . LEU A 1 403 ? 128.253 135.583 157.383 1.00 59.43  ? 403 LEU B CG  1 
ATOM   2266 C CD1 . LEU A 1 403 ? 126.804 135.346 157.780 1.00 59.43  ? 403 LEU B CD1 1 
ATOM   2267 C CD2 . LEU A 1 403 ? 129.158 135.517 158.601 1.00 59.43  ? 403 LEU B CD2 1 
ATOM   2268 N N   . ILE A 1 404 ? 129.263 136.280 153.765 1.00 57.92  ? 404 ILE B N   1 
ATOM   2269 C CA  . ILE A 1 404 ? 129.434 137.596 153.157 1.00 57.92  ? 404 ILE B CA  1 
ATOM   2270 C C   . ILE A 1 404 ? 128.565 137.746 151.921 1.00 57.92  ? 404 ILE B C   1 
ATOM   2271 O O   . ILE A 1 404 ? 128.114 138.850 151.613 1.00 57.92  ? 404 ILE B O   1 
ATOM   2272 C CB  . ILE A 1 404 ? 130.909 137.890 152.839 1.00 57.92  ? 404 ILE B CB  1 
ATOM   2273 C CG1 . ILE A 1 404 ? 131.463 136.894 151.818 1.00 57.92  ? 404 ILE B CG1 1 
ATOM   2274 C CG2 . ILE A 1 404 ? 131.702 137.930 154.114 1.00 57.92  ? 404 ILE B CG2 1 
ATOM   2275 C CD1 . ILE A 1 404 ? 132.809 137.286 151.256 1.00 57.92  ? 404 ILE B CD1 1 
ATOM   2276 N N   . THR A 1 405 ? 128.298 136.658 151.199 1.00 60.73  ? 405 THR B N   1 
ATOM   2277 C CA  . THR A 1 405 ? 127.486 136.759 149.995 1.00 60.73  ? 405 THR B CA  1 
ATOM   2278 C C   . THR A 1 405 ? 126.043 137.101 150.345 1.00 60.73  ? 405 THR B C   1 
ATOM   2279 O O   . THR A 1 405 ? 125.440 137.997 149.738 1.00 60.73  ? 405 THR B O   1 
ATOM   2280 C CB  . THR A 1 405 ? 127.575 135.450 149.212 1.00 60.73  ? 405 THR B CB  1 
ATOM   2281 O OG1 . THR A 1 405 ? 128.953 135.107 149.021 1.00 60.73  ? 405 THR B OG1 1 
ATOM   2282 C CG2 . THR A 1 405 ? 126.940 135.604 147.855 1.00 60.73  ? 405 THR B CG2 1 
ATOM   2283 N N   . ILE A 1 406 ? 125.480 136.418 151.347 1.00 59.61  ? 406 ILE B N   1 
ATOM   2284 C CA  . ILE A 1 406 ? 124.122 136.756 151.767 1.00 59.61  ? 406 ILE B CA  1 
ATOM   2285 C C   . ILE A 1 406 ? 124.086 138.159 152.369 1.00 59.61  ? 406 ILE B C   1 
ATOM   2286 O O   . ILE A 1 406 ? 123.106 138.900 152.194 1.00 59.61  ? 406 ILE B O   1 
ATOM   2287 C CB  . ILE A 1 406 ? 123.556 135.688 152.726 1.00 59.61  ? 406 ILE B CB  1 
ATOM   2288 C CG1 . ILE A 1 406 ? 122.063 135.920 152.968 1.00 59.61  ? 406 ILE B CG1 1 
ATOM   2289 C CG2 . ILE A 1 406 ? 124.293 135.658 154.047 1.00 59.61  ? 406 ILE B CG2 1 
ATOM   2290 C CD1 . ILE A 1 406 ? 121.361 134.739 153.602 1.00 59.61  ? 406 ILE B CD1 1 
ATOM   2291 N N   . ALA A 1 407 ? 125.161 138.562 153.053 1.00 61.70  ? 407 ALA B N   1 
ATOM   2292 C CA  . ALA A 1 407 ? 125.241 139.927 153.563 1.00 61.70  ? 407 ALA B CA  1 
ATOM   2293 C C   . ALA A 1 407 ? 125.213 140.939 152.423 1.00 61.70  ? 407 ALA B C   1 
ATOM   2294 O O   . ALA A 1 407 ? 124.551 141.978 152.517 1.00 61.70  ? 407 ALA B O   1 
ATOM   2295 C CB  . ALA A 1 407 ? 126.506 140.094 154.405 1.00 61.70  ? 407 ALA B CB  1 
ATOM   2296 N N   . THR A 1 408 ? 125.939 140.653 151.341 1.00 61.37  ? 408 THR B N   1 
ATOM   2297 C CA  . THR A 1 408 ? 125.952 141.553 150.193 1.00 61.37  ? 408 THR B CA  1 
ATOM   2298 C C   . THR A 1 408 ? 124.585 141.637 149.532 1.00 61.37  ? 408 THR B C   1 
ATOM   2299 O O   . THR A 1 408 ? 124.153 142.731 149.154 1.00 61.37  ? 408 THR B O   1 
ATOM   2300 C CB  . THR A 1 408 ? 127.011 141.123 149.175 1.00 61.37  ? 408 THR B CB  1 
ATOM   2301 O OG1 . THR A 1 408 ? 126.779 139.766 148.771 1.00 61.37  ? 408 THR B OG1 1 
ATOM   2302 C CG2 . THR A 1 408 ? 128.418 141.283 149.738 1.00 61.37  ? 408 THR B CG2 1 
ATOM   2303 N N   . PHE A 1 409 ? 123.887 140.505 149.374 1.00 64.99  ? 409 PHE B N   1 
ATOM   2304 C CA  . PHE A 1 409 ? 122.527 140.586 148.836 1.00 64.99  ? 409 PHE B CA  1 
ATOM   2305 C C   . PHE A 1 409 ? 121.629 141.441 149.721 1.00 64.99  ? 409 PHE B C   1 
ATOM   2306 O O   . PHE A 1 409 ? 120.881 142.290 149.222 1.00 64.99  ? 409 PHE B O   1 
ATOM   2307 C CB  . PHE A 1 409 ? 121.888 139.208 148.627 1.00 64.99  ? 409 PHE B CB  1 
ATOM   2308 C CG  . PHE A 1 409 ? 122.520 138.386 147.541 1.00 64.99  ? 409 PHE B CG  1 
ATOM   2309 C CD1 . PHE A 1 409 ? 122.196 138.628 146.215 1.00 64.99  ? 409 PHE B CD1 1 
ATOM   2310 C CD2 . PHE A 1 409 ? 123.333 137.312 147.833 1.00 64.99  ? 409 PHE B CD2 1 
ATOM   2311 C CE1 . PHE A 1 409 ? 122.741 137.868 145.200 1.00 64.99  ? 409 PHE B CE1 1 
ATOM   2312 C CE2 . PHE A 1 409 ? 123.875 136.545 146.822 1.00 64.99  ? 409 PHE B CE2 1 
ATOM   2313 C CZ  . PHE A 1 409 ? 123.580 136.822 145.505 1.00 64.99  ? 409 PHE B CZ  1 
ATOM   2314 N N   . GLN A 1 410 ? 121.690 141.237 151.039 1.00 60.19  ? 410 GLN B N   1 
ATOM   2315 C CA  . GLN A 1 410 ? 120.824 142.011 151.923 1.00 60.19  ? 410 GLN B CA  1 
ATOM   2316 C C   . GLN A 1 410 ? 121.151 143.499 151.864 1.00 60.19  ? 410 GLN B C   1 
ATOM   2317 O O   . GLN A 1 410 ? 120.247 144.341 151.784 1.00 60.19  ? 410 GLN B O   1 
ATOM   2318 C CB  . GLN A 1 410 ? 120.934 141.496 153.355 1.00 60.19  ? 410 GLN B CB  1 
ATOM   2319 C CG  . GLN A 1 410 ? 119.718 141.817 154.201 1.00 60.19  ? 410 GLN B CG  1 
ATOM   2320 C CD  . GLN A 1 410 ? 118.560 140.880 153.934 1.00 60.19  ? 410 GLN B CD  1 
ATOM   2321 O OE1 . GLN A 1 410 ? 118.671 139.947 153.138 1.00 60.19  ? 410 GLN B OE1 1 
ATOM   2322 N NE2 . GLN A 1 410 ? 117.438 141.122 154.601 1.00 60.19  ? 410 GLN B NE2 1 
ATOM   2323 N N   . ILE A 1 411 ? 122.440 143.841 151.883 1.00 60.81  ? 411 ILE B N   1 
ATOM   2324 C CA  . ILE A 1 411 ? 122.838 145.246 151.859 1.00 60.81  ? 411 ILE B CA  1 
ATOM   2325 C C   . ILE A 1 411 ? 122.442 145.888 150.534 1.00 60.81  ? 411 ILE B C   1 
ATOM   2326 O O   . ILE A 1 411 ? 121.886 146.992 150.504 1.00 60.81  ? 411 ILE B O   1 
ATOM   2327 C CB  . ILE A 1 411 ? 124.347 145.382 152.131 1.00 60.81  ? 411 ILE B CB  1 
ATOM   2328 C CG1 . ILE A 1 411 ? 124.654 145.026 153.586 1.00 60.81  ? 411 ILE B CG1 1 
ATOM   2329 C CG2 . ILE A 1 411 ? 124.820 146.794 151.824 1.00 60.81  ? 411 ILE B CG2 1 
ATOM   2330 C CD1 . ILE A 1 411 ? 126.129 144.905 153.888 1.00 60.81  ? 411 ILE B CD1 1 
ATOM   2331 N N   . ALA A 1 412 ? 122.703 145.197 149.419 1.00 60.14  ? 412 ALA B N   1 
ATOM   2332 C CA  . ALA A 1 412 ? 122.356 145.740 148.111 1.00 60.14  ? 412 ALA B CA  1 
ATOM   2333 C C   . ALA A 1 412 ? 120.852 145.904 147.955 1.00 60.14  ? 412 ALA B C   1 
ATOM   2334 O O   . ALA A 1 412 ? 120.398 146.855 147.309 1.00 60.14  ? 412 ALA B O   1 
ATOM   2335 C CB  . ALA A 1 412 ? 122.913 144.846 147.004 1.00 60.14  ? 412 ALA B CB  1 
ATOM   2336 N N   . ALA A 1 413 ? 120.064 144.993 148.531 1.00 59.34  ? 413 ALA B N   1 
ATOM   2337 C CA  . ALA A 1 413 ? 118.622 145.200 148.569 1.00 59.34  ? 413 ALA B CA  1 
ATOM   2338 C C   . ALA A 1 413 ? 118.279 146.442 149.377 1.00 59.34  ? 413 ALA B C   1 
ATOM   2339 O O   . ALA A 1 413 ? 117.386 147.212 149.003 1.00 59.34  ? 413 ALA B O   1 
ATOM   2340 C CB  . ALA A 1 413 ? 117.928 143.969 149.149 1.00 59.34  ? 413 ALA B CB  1 
ATOM   2341 N N   . ASN A 1 414 ? 118.982 146.655 150.490 1.00 58.95  ? 414 ASN B N   1 
ATOM   2342 C CA  . ASN A 1 414 ? 118.758 147.855 151.287 1.00 58.95  ? 414 ASN B CA  1 
ATOM   2343 C C   . ASN A 1 414 ? 119.355 149.096 150.631 1.00 58.95  ? 414 ASN B C   1 
ATOM   2344 O O   . ASN A 1 414 ? 118.783 150.187 150.731 1.00 58.95  ? 414 ASN B O   1 
ATOM   2345 C CB  . ASN A 1 414 ? 119.339 147.665 152.689 1.00 58.95  ? 414 ASN B CB  1 
ATOM   2346 N N   . LEU A 1 415 ? 120.492 148.953 149.954 1.00 55.68  ? 415 LEU B N   1 
ATOM   2347 C CA  . LEU A 1 415 ? 121.241 150.106 149.474 1.00 55.68  ? 415 LEU B CA  1 
ATOM   2348 C C   . LEU A 1 415 ? 120.625 150.673 148.197 1.00 55.68  ? 415 LEU B C   1 
ATOM   2349 O O   . LEU A 1 415 ? 119.630 150.168 147.667 1.00 55.68  ? 415 LEU B O   1 
ATOM   2350 C CB  . LEU A 1 415 ? 122.704 149.733 149.245 1.00 55.68  ? 415 LEU B CB  1 
ATOM   2351 N N   . SER A 1 416 ? 121.235 151.745 147.701 1.00 57.73  ? 416 SER B N   1 
ATOM   2352 C CA  . SER A 1 416 ? 120.807 152.450 146.503 1.00 57.73  ? 416 SER B CA  1 
ATOM   2353 C C   . SER A 1 416 ? 121.852 152.301 145.404 1.00 57.73  ? 416 SER B C   1 
ATOM   2354 O O   . SER A 1 416 ? 122.964 151.815 145.628 1.00 57.73  ? 416 SER B O   1 
ATOM   2355 C CB  . SER A 1 416 ? 120.556 153.932 146.806 1.00 57.73  ? 416 SER B CB  1 
ATOM   2356 N N   . MET A 1 417 ? 121.472 152.736 144.199 1.00 58.96  ? 417 MET B N   1 
ATOM   2357 C CA  . MET A 1 417 ? 122.331 152.563 143.031 1.00 58.96  ? 417 MET B CA  1 
ATOM   2358 C C   . MET A 1 417 ? 123.611 153.384 143.141 1.00 58.96  ? 417 MET B C   1 
ATOM   2359 O O   . MET A 1 417 ? 124.683 152.929 142.723 1.00 58.96  ? 417 MET B O   1 
ATOM   2360 C CB  . MET A 1 417 ? 121.567 152.934 141.760 1.00 58.96  ? 417 MET B CB  1 
ATOM   2361 N N   . GLU A 1 418 ? 123.522 154.600 143.672 1.00 53.57  ? 418 GLU B N   1 
ATOM   2362 C CA  . GLU A 1 418 ? 124.685 155.471 143.775 1.00 53.57  ? 418 GLU B CA  1 
ATOM   2363 C C   . GLU A 1 418 ? 125.422 155.341 145.101 1.00 53.57  ? 418 GLU B C   1 
ATOM   2364 O O   . GLU A 1 418 ? 126.470 155.973 145.271 1.00 53.57  ? 418 GLU B O   1 
ATOM   2365 C CB  . GLU A 1 418 ? 124.269 156.932 143.569 1.00 53.57  ? 418 GLU B CB  1 
ATOM   2366 N N   . ARG A 1 419 ? 124.912 154.546 146.037 1.00 60.58  ? 419 ARG B N   1 
ATOM   2367 C CA  . ARG A 1 419 ? 125.470 154.475 147.380 1.00 60.58  ? 419 ARG B CA  1 
ATOM   2368 C C   . ARG A 1 419 ? 126.457 153.331 147.575 1.00 60.58  ? 419 ARG B C   1 
ATOM   2369 O O   . ARG A 1 419 ? 127.015 153.204 148.671 1.00 60.58  ? 419 ARG B O   1 
ATOM   2370 C CB  . ARG A 1 419 ? 124.339 154.354 148.408 1.00 60.58  ? 419 ARG B CB  1 
ATOM   2371 N N   . TYR A 1 420 ? 126.687 152.502 146.551 1.00 65.55  ? 420 TYR B N   1 
ATOM   2372 C CA  . TYR A 1 420 ? 127.550 151.333 146.719 1.00 65.55  ? 420 TYR B CA  1 
ATOM   2373 C C   . TYR A 1 420 ? 128.966 151.735 147.108 1.00 65.55  ? 420 TYR B C   1 
ATOM   2374 O O   . TYR A 1 420 ? 129.522 151.216 148.082 1.00 65.55  ? 420 TYR B O   1 
ATOM   2375 C CB  . TYR A 1 420 ? 127.580 150.494 145.441 1.00 65.55  ? 420 TYR B CB  1 
ATOM   2376 C CG  . TYR A 1 420 ? 126.276 149.821 145.089 1.00 65.55  ? 420 TYR B CG  1 
ATOM   2377 C CD1 . TYR A 1 420 ? 125.896 148.640 145.710 1.00 65.55  ? 420 TYR B CD1 1 
ATOM   2378 C CD2 . TYR A 1 420 ? 125.444 150.344 144.114 1.00 65.55  ? 420 TYR B CD2 1 
ATOM   2379 C CE1 . TYR A 1 420 ? 124.709 148.012 145.386 1.00 65.55  ? 420 TYR B CE1 1 
ATOM   2380 C CE2 . TYR A 1 420 ? 124.258 149.723 143.779 1.00 65.55  ? 420 TYR B CE2 1 
ATOM   2381 C CZ  . TYR A 1 420 ? 123.893 148.559 144.420 1.00 65.55  ? 420 TYR B CZ  1 
ATOM   2382 O OH  . TYR A 1 420 ? 122.710 147.941 144.087 1.00 65.55  ? 420 TYR B OH  1 
ATOM   2383 N N   . ALA A 1 421 ? 129.571 152.646 146.344 1.00 67.25  ? 421 ALA B N   1 
ATOM   2384 C CA  . ALA A 1 421 ? 130.952 153.031 146.613 1.00 67.25  ? 421 ALA B CA  1 
ATOM   2385 C C   . ALA A 1 421 ? 131.084 153.687 147.980 1.00 67.25  ? 421 ALA B C   1 
ATOM   2386 O O   . ALA A 1 421 ? 132.018 153.387 148.732 1.00 67.25  ? 421 ALA B O   1 
ATOM   2387 C CB  . ALA A 1 421 ? 131.461 153.965 145.517 1.00 67.25  ? 421 ALA B CB  1 
ATOM   2388 N N   . LEU A 1 422 ? 130.147 154.572 148.327 1.00 70.10  ? 422 LEU B N   1 
ATOM   2389 C CA  . LEU A 1 422 ? 130.233 155.273 149.604 1.00 70.10  ? 422 LEU B CA  1 
ATOM   2390 C C   . LEU A 1 422 ? 130.078 154.312 150.778 1.00 70.10  ? 422 LEU B C   1 
ATOM   2391 O O   . LEU A 1 422 ? 130.823 154.407 151.764 1.00 70.10  ? 422 LEU B O   1 
ATOM   2392 C CB  . LEU A 1 422 ? 129.185 156.388 149.654 1.00 70.10  ? 422 LEU B CB  1 
ATOM   2393 C CG  . LEU A 1 422 ? 129.196 157.397 150.808 1.00 70.10  ? 422 LEU B CG  1 
ATOM   2394 C CD1 . LEU A 1 422 ? 128.607 158.708 150.327 1.00 70.10  ? 422 LEU B CD1 1 
ATOM   2395 C CD2 . LEU A 1 422 ? 128.417 156.900 152.018 1.00 70.10  ? 422 LEU B CD2 1 
ATOM   2396 N N   . VAL A 1 423 ? 129.127 153.376 150.697 1.00 69.08  ? 423 VAL B N   1 
ATOM   2397 C CA  . VAL A 1 423 ? 128.941 152.452 151.812 1.00 69.08  ? 423 VAL B CA  1 
ATOM   2398 C C   . VAL A 1 423 ? 130.114 151.482 151.904 1.00 69.08  ? 423 VAL B C   1 
ATOM   2399 O O   . VAL A 1 423 ? 130.595 151.177 153.003 1.00 69.08  ? 423 VAL B O   1 
ATOM   2400 C CB  . VAL A 1 423 ? 127.582 151.727 151.715 1.00 69.08  ? 423 VAL B CB  1 
ATOM   2401 C CG1 . VAL A 1 423 ? 127.537 150.727 150.564 1.00 69.08  ? 423 VAL B CG1 1 
ATOM   2402 C CG2 . VAL A 1 423 ? 127.257 151.040 153.036 1.00 69.08  ? 423 VAL B CG2 1 
ATOM   2403 N N   . PHE A 1 424 ? 130.617 151.006 150.758 1.00 70.80  ? 424 PHE B N   1 
ATOM   2404 C CA  . PHE A 1 424 ? 131.765 150.111 150.763 1.00 70.80  ? 424 PHE B CA  1 
ATOM   2405 C C   . PHE A 1 424 ? 133.035 150.826 151.187 1.00 70.80  ? 424 PHE B C   1 
ATOM   2406 O O   . PHE A 1 424 ? 134.009 150.165 151.555 1.00 70.80  ? 424 PHE B O   1 
ATOM   2407 C CB  . PHE A 1 424 ? 131.954 149.485 149.381 1.00 70.80  ? 424 PHE B CB  1 
ATOM   2408 N N   . GLY A 1 425 ? 133.052 152.153 151.123 1.00 69.01  ? 425 GLY B N   1 
ATOM   2409 C CA  . GLY A 1 425 ? 134.151 152.911 151.673 1.00 69.01  ? 425 GLY B CA  1 
ATOM   2410 C C   . GLY A 1 425 ? 134.043 153.059 153.175 1.00 69.01  ? 425 GLY B C   1 
ATOM   2411 O O   . GLY A 1 425 ? 135.009 152.794 153.894 1.00 69.01  ? 425 GLY B O   1 
ATOM   2412 N N   . VAL A 1 426 ? 132.868 153.466 153.665 1.00 71.76  ? 426 VAL B N   1 
ATOM   2413 C CA  . VAL A 1 426 ? 132.743 153.760 155.092 1.00 71.76  ? 426 VAL B CA  1 
ATOM   2414 C C   . VAL A 1 426 ? 132.830 152.482 155.927 1.00 71.76  ? 426 VAL B C   1 
ATOM   2415 O O   . VAL A 1 426 ? 133.506 152.452 156.967 1.00 71.76  ? 426 VAL B O   1 
ATOM   2416 C CB  . VAL A 1 426 ? 131.452 154.554 155.380 1.00 71.76  ? 426 VAL B CB  1 
ATOM   2417 C CG1 . VAL A 1 426 ? 131.529 155.933 154.742 1.00 71.76  ? 426 VAL B CG1 1 
ATOM   2418 C CG2 . VAL A 1 426 ? 130.218 153.816 154.897 1.00 71.76  ? 426 VAL B CG2 1 
ATOM   2419 N N   . ASN A 1 427 ? 132.162 151.406 155.494 1.00 71.10  ? 427 ASN B N   1 
ATOM   2420 C CA  . ASN A 1 427 ? 132.212 150.175 156.277 1.00 71.10  ? 427 ASN B CA  1 
ATOM   2421 C C   . ASN A 1 427 ? 133.606 149.563 156.243 1.00 71.10  ? 427 ASN B C   1 
ATOM   2422 O O   . ASN A 1 427 ? 134.081 149.033 157.252 1.00 71.10  ? 427 ASN B O   1 
ATOM   2423 C CB  . ASN A 1 427 ? 131.155 149.180 155.789 1.00 71.10  ? 427 ASN B CB  1 
ATOM   2424 C CG  . ASN A 1 427 ? 131.371 148.728 154.352 1.00 71.10  ? 427 ASN B CG  1 
ATOM   2425 O OD1 . ASN A 1 427 ? 132.383 149.040 153.723 1.00 71.10  ? 427 ASN B OD1 1 
ATOM   2426 N ND2 . ASN A 1 427 ? 130.395 148.003 153.818 1.00 71.10  ? 427 ASN B ND2 1 
ATOM   2427 N N   . THR A 1 428 ? 134.281 149.642 155.095 1.00 71.22  ? 428 THR B N   1 
ATOM   2428 C CA  . THR A 1 428 ? 135.656 149.165 155.021 1.00 71.22  ? 428 THR B CA  1 
ATOM   2429 C C   . THR A 1 428 ? 136.568 149.995 155.914 1.00 71.22  ? 428 THR B C   1 
ATOM   2430 O O   . THR A 1 428 ? 137.469 149.455 156.561 1.00 71.22  ? 428 THR B O   1 
ATOM   2431 C CB  . THR A 1 428 ? 136.152 149.192 153.577 1.00 71.22  ? 428 THR B CB  1 
ATOM   2432 O OG1 . THR A 1 428 ? 135.230 148.478 152.745 1.00 71.22  ? 428 THR B OG1 1 
ATOM   2433 C CG2 . THR A 1 428 ? 137.519 148.537 153.470 1.00 71.22  ? 428 THR B CG2 1 
ATOM   2434 N N   . PHE A 1 429 ? 136.343 151.310 155.973 1.00 75.37  ? 429 PHE B N   1 
ATOM   2435 C CA  . PHE A 1 429 ? 137.166 152.161 156.825 1.00 75.37  ? 429 PHE B CA  1 
ATOM   2436 C C   . PHE A 1 429 ? 136.997 151.797 158.294 1.00 75.37  ? 429 PHE B C   1 
ATOM   2437 O O   . PHE A 1 429 ? 137.983 151.662 159.031 1.00 75.37  ? 429 PHE B O   1 
ATOM   2438 C CB  . PHE A 1 429 ? 136.818 153.631 156.595 1.00 75.37  ? 429 PHE B CB  1 
ATOM   2439 C CG  . PHE A 1 429 ? 137.499 154.567 157.552 1.00 75.37  ? 429 PHE B CG  1 
ATOM   2440 C CD1 . PHE A 1 429 ? 138.867 154.774 157.484 1.00 75.37  ? 429 PHE B CD1 1 
ATOM   2441 C CD2 . PHE A 1 429 ? 136.772 155.236 158.523 1.00 75.37  ? 429 PHE B CD2 1 
ATOM   2442 C CE1 . PHE A 1 429 ? 139.497 155.631 158.363 1.00 75.37  ? 429 PHE B CE1 1 
ATOM   2443 C CE2 . PHE A 1 429 ? 137.396 156.095 159.406 1.00 75.37  ? 429 PHE B CE2 1 
ATOM   2444 C CZ  . PHE A 1 429 ? 138.762 156.293 159.325 1.00 75.37  ? 429 PHE B CZ  1 
ATOM   2445 N N   . ILE A 1 430 ? 135.750 151.632 158.742 1.00 68.46  ? 430 ILE B N   1 
ATOM   2446 C CA  . ILE A 1 430 ? 135.550 151.288 160.148 1.00 68.46  ? 430 ILE B CA  1 
ATOM   2447 C C   . ILE A 1 430 ? 136.061 149.879 160.435 1.00 68.46  ? 430 ILE B C   1 
ATOM   2448 O O   . ILE A 1 430 ? 136.635 149.625 161.505 1.00 68.46  ? 430 ILE B O   1 
ATOM   2449 C CB  . ILE A 1 430 ? 134.076 151.477 160.563 1.00 68.46  ? 430 ILE B CB  1 
ATOM   2450 C CG1 . ILE A 1 430 ? 133.955 151.459 162.088 1.00 68.46  ? 430 ILE B CG1 1 
ATOM   2451 C CG2 . ILE A 1 430 ? 133.170 150.429 159.939 1.00 68.46  ? 430 ILE B CG2 1 
ATOM   2452 C CD1 . ILE A 1 430 ? 134.756 152.543 162.778 1.00 68.46  ? 430 ILE B CD1 1 
ATOM   2453 N N   . ALA A 1 431 ? 135.914 148.954 159.481 1.00 67.69  ? 431 ALA B N   1 
ATOM   2454 C CA  . ALA A 1 431 ? 136.453 147.613 159.665 1.00 67.69  ? 431 ALA B CA  1 
ATOM   2455 C C   . ALA A 1 431 ? 137.968 147.645 159.801 1.00 67.69  ? 431 ALA B C   1 
ATOM   2456 O O   . ALA A 1 431 ? 138.530 146.967 160.667 1.00 67.69  ? 431 ALA B O   1 
ATOM   2457 C CB  . ALA A 1 431 ? 136.033 146.714 158.502 1.00 67.69  ? 431 ALA B CB  1 
ATOM   2458 N N   . LEU A 1 432 ? 138.644 148.433 158.958 1.00 66.31  ? 432 LEU B N   1 
ATOM   2459 C CA  . LEU A 1 432 ? 140.099 148.521 159.030 1.00 66.31  ? 432 LEU B CA  1 
ATOM   2460 C C   . LEU A 1 432 ? 140.558 149.178 160.320 1.00 66.31  ? 432 LEU B C   1 
ATOM   2461 O O   . LEU A 1 432 ? 141.547 148.741 160.922 1.00 66.31  ? 432 LEU B O   1 
ATOM   2462 C CB  . LEU A 1 432 ? 140.666 149.233 157.804 1.00 66.31  ? 432 LEU B CB  1 
ATOM   2463 C CG  . LEU A 1 432 ? 140.987 148.291 156.639 1.00 66.31  ? 432 LEU B CG  1 
ATOM   2464 C CD1 . LEU A 1 432 ? 142.139 147.392 157.069 1.00 66.31  ? 432 LEU B CD1 1 
ATOM   2465 C CD2 . LEU A 1 432 ? 139.815 147.445 156.162 1.00 66.31  ? 432 LEU B CD2 1 
ATOM   2466 N N   . ALA A 1 433 ? 139.850 150.216 160.768 1.00 66.85  ? 433 ALA B N   1 
ATOM   2467 C CA  . ALA A 1 433 ? 140.121 150.755 162.094 1.00 66.85  ? 433 ALA B CA  1 
ATOM   2468 C C   . ALA A 1 433 ? 140.004 149.665 163.150 1.00 66.85  ? 433 ALA B C   1 
ATOM   2469 O O   . ALA A 1 433 ? 140.803 149.610 164.093 1.00 66.85  ? 433 ALA B O   1 
ATOM   2470 C CB  . ALA A 1 433 ? 139.170 151.912 162.398 1.00 66.85  ? 433 ALA B CB  1 
ATOM   2471 N N   . LEU A 1 434 ? 139.041 148.755 162.980 1.00 72.90  ? 434 LEU B N   1 
ATOM   2472 C CA  . LEU A 1 434 ? 138.832 147.714 163.981 1.00 72.90  ? 434 LEU B CA  1 
ATOM   2473 C C   . LEU A 1 434 ? 139.953 146.670 163.956 1.00 72.90  ? 434 LEU B C   1 
ATOM   2474 O O   . LEU A 1 434 ? 140.444 146.258 165.021 1.00 72.90  ? 434 LEU B O   1 
ATOM   2475 C CB  . LEU A 1 434 ? 137.455 147.077 163.772 1.00 72.90  ? 434 LEU B CB  1 
ATOM   2476 C CG  . LEU A 1 434 ? 136.897 146.083 164.796 1.00 72.90  ? 434 LEU B CG  1 
ATOM   2477 C CD1 . LEU A 1 434 ? 135.376 146.113 164.750 1.00 72.90  ? 434 LEU B CD1 1 
ATOM   2478 C CD2 . LEU A 1 434 ? 137.392 144.670 164.586 1.00 72.90  ? 434 LEU B CD2 1 
ATOM   2479 N N   . GLN A 1 435 ? 140.370 146.212 162.762 1.00 65.66  ? 435 GLN B N   1 
ATOM   2480 C CA  . GLN A 1 435 ? 141.471 145.245 162.748 1.00 65.66  ? 435 GLN B CA  1 
ATOM   2481 C C   . GLN A 1 435 ? 142.738 145.890 163.282 1.00 65.66  ? 435 GLN B C   1 
ATOM   2482 O O   . GLN A 1 435 ? 143.522 145.240 163.978 1.00 65.66  ? 435 GLN B O   1 
ATOM   2483 C CB  . GLN A 1 435 ? 141.804 144.640 161.371 1.00 65.66  ? 435 GLN B CB  1 
ATOM   2484 C CG  . GLN A 1 435 ? 140.774 143.770 160.663 1.00 65.66  ? 435 GLN B CG  1 
ATOM   2485 C CD  . GLN A 1 435 ? 139.919 144.576 159.738 1.00 65.66  ? 435 GLN B CD  1 
ATOM   2486 O OE1 . GLN A 1 435 ? 140.327 145.646 159.340 1.00 65.66  ? 435 GLN B OE1 1 
ATOM   2487 N NE2 . GLN A 1 435 ? 138.740 144.090 159.395 1.00 65.66  ? 435 GLN B NE2 1 
ATOM   2488 N N   . THR A 1 436 ? 142.962 147.165 162.950 1.00 65.88  ? 436 THR B N   1 
ATOM   2489 C CA  . THR A 1 436 ? 144.128 147.865 163.471 1.00 65.88  ? 436 THR B CA  1 
ATOM   2490 C C   . THR A 1 436 ? 144.086 147.941 164.990 1.00 65.88  ? 436 THR B C   1 
ATOM   2491 O O   . THR A 1 436 ? 145.099 147.702 165.656 1.00 65.88  ? 436 THR B O   1 
ATOM   2492 C CB  . THR A 1 436 ? 144.210 149.264 162.866 1.00 65.88  ? 436 THR B CB  1 
ATOM   2493 O OG1 . THR A 1 436 ? 144.425 149.161 161.453 1.00 65.88  ? 436 THR B OG1 1 
ATOM   2494 C CG2 . THR A 1 436 ? 145.346 150.055 163.491 1.00 65.88  ? 436 THR B CG2 1 
ATOM   2495 N N   . LEU A 1 437 ? 142.918 148.253 165.555 1.00 61.39  ? 437 LEU B N   1 
ATOM   2496 C CA  . LEU A 1 437 ? 142.791 148.284 167.007 1.00 61.39  ? 437 LEU B CA  1 
ATOM   2497 C C   . LEU A 1 437 ? 143.167 146.940 167.613 1.00 61.39  ? 437 LEU B C   1 
ATOM   2498 O O   . LEU A 1 437 ? 144.053 146.861 168.475 1.00 61.39  ? 437 LEU B O   1 
ATOM   2499 C CB  . LEU A 1 437 ? 141.366 148.671 167.398 1.00 61.39  ? 437 LEU B CB  1 
ATOM   2500 C CG  . LEU A 1 437 ? 141.180 149.164 168.833 1.00 61.39  ? 437 LEU B CG  1 
ATOM   2501 C CD1 . LEU A 1 437 ? 142.294 150.127 169.221 1.00 61.39  ? 437 LEU B CD1 1 
ATOM   2502 C CD2 . LEU A 1 437 ? 139.813 149.815 168.995 1.00 61.39  ? 437 LEU B CD2 1 
ATOM   2503 N N   . LEU A 1 438 ? 142.549 145.861 167.124 1.00 57.58  ? 438 LEU B N   1 
ATOM   2504 C CA  . LEU A 1 438 ? 142.853 144.546 167.682 1.00 57.58  ? 438 LEU B CA  1 
ATOM   2505 C C   . LEU A 1 438 ? 144.320 144.180 167.478 1.00 57.58  ? 438 LEU B C   1 
ATOM   2506 O O   . LEU A 1 438 ? 144.908 143.475 168.307 1.00 57.58  ? 438 LEU B O   1 
ATOM   2507 C CB  . LEU A 1 438 ? 141.938 143.486 167.071 1.00 57.58  ? 438 LEU B CB  1 
ATOM   2508 C CG  . LEU A 1 438 ? 142.092 142.087 167.665 1.00 57.58  ? 438 LEU B CG  1 
ATOM   2509 C CD1 . LEU A 1 438 ? 141.772 142.115 169.149 1.00 57.58  ? 438 LEU B CD1 1 
ATOM   2510 C CD2 . LEU A 1 438 ? 141.192 141.105 166.948 1.00 57.58  ? 438 LEU B CD2 1 
ATOM   2511 N N   . THR A 1 439 ? 144.928 144.669 166.395 1.00 57.31  ? 439 THR B N   1 
ATOM   2512 C CA  . THR A 1 439 ? 146.363 144.501 166.198 1.00 57.31  ? 439 THR B CA  1 
ATOM   2513 C C   . THR A 1 439 ? 147.153 145.193 167.302 1.00 57.31  ? 439 THR B C   1 
ATOM   2514 O O   . THR A 1 439 ? 148.129 144.636 167.814 1.00 57.31  ? 439 THR B O   1 
ATOM   2515 C CB  . THR A 1 439 ? 146.757 145.038 164.822 1.00 57.31  ? 439 THR B CB  1 
ATOM   2516 O OG1 . THR A 1 439 ? 146.051 144.312 163.808 1.00 57.31  ? 439 THR B OG1 1 
ATOM   2517 C CG2 . THR A 1 439 ? 148.252 144.913 164.590 1.00 57.31  ? 439 THR B CG2 1 
ATOM   2518 N N   . LEU A 1 440 ? 146.734 146.402 167.692 1.00 58.39  ? 440 LEU B N   1 
ATOM   2519 C CA  . LEU A 1 440 ? 147.364 147.059 168.837 1.00 58.39  ? 440 LEU B CA  1 
ATOM   2520 C C   . LEU A 1 440 ? 147.215 146.241 170.116 1.00 58.39  ? 440 LEU B C   1 
ATOM   2521 O O   . LEU A 1 440 ? 148.145 146.190 170.929 1.00 58.39  ? 440 LEU B O   1 
ATOM   2522 C CB  . LEU A 1 440 ? 146.823 148.478 169.053 1.00 58.39  ? 440 LEU B CB  1 
ATOM   2523 C CG  . LEU A 1 440 ? 147.350 149.693 168.269 1.00 58.39  ? 440 LEU B CG  1 
ATOM   2524 C CD1 . LEU A 1 440 ? 146.952 149.746 166.817 1.00 58.39  ? 440 LEU B CD1 1 
ATOM   2525 C CD2 . LEU A 1 440 ? 146.927 150.979 168.975 1.00 58.39  ? 440 LEU B CD2 1 
ATOM   2526 N N   . ILE A 1 441 ? 146.056 145.612 170.333 1.00 59.38  ? 441 ILE B N   1 
ATOM   2527 C CA  . ILE A 1 441 ? 145.932 144.782 171.537 1.00 59.38  ? 441 ILE B CA  1 
ATOM   2528 C C   . ILE A 1 441 ? 146.876 143.580 171.488 1.00 59.38  ? 441 ILE B C   1 
ATOM   2529 O O   . ILE A 1 441 ? 147.653 143.357 172.423 1.00 59.38  ? 441 ILE B O   1 
ATOM   2530 C CB  . ILE A 1 441 ? 144.484 144.335 171.831 1.00 59.38  ? 441 ILE B CB  1 
ATOM   2531 C CG1 . ILE A 1 441 ? 143.533 145.499 172.147 1.00 59.38  ? 441 ILE B CG1 1 
ATOM   2532 C CG2 . ILE A 1 441 ? 144.466 143.337 172.981 1.00 59.38  ? 441 ILE B CG2 1 
ATOM   2533 C CD1 . ILE A 1 441 ? 142.835 146.129 171.018 1.00 59.38  ? 441 ILE B CD1 1 
ATOM   2534 N N   . VAL A 1 442 ? 146.840 142.789 170.417 1.00 55.34  ? 442 VAL B N   1 
ATOM   2535 C CA  . VAL A 1 442 ? 147.467 141.467 170.424 1.00 55.34  ? 442 VAL B CA  1 
ATOM   2536 C C   . VAL A 1 442 ? 148.707 141.398 169.531 1.00 55.34  ? 442 VAL B C   1 
ATOM   2537 O O   . VAL A 1 442 ? 149.768 140.960 169.975 1.00 55.34  ? 442 VAL B O   1 
ATOM   2538 C CB  . VAL A 1 442 ? 146.455 140.351 170.065 1.00 55.34  ? 442 VAL B CB  1 
ATOM   2539 C CG1 . VAL A 1 442 ? 145.787 140.582 168.724 1.00 55.34  ? 442 VAL B CG1 1 
ATOM   2540 C CG2 . VAL A 1 442 ? 147.150 138.995 170.077 1.00 55.34  ? 442 VAL B CG2 1 
ATOM   2541 N N   . VAL A 1 443 ? 148.595 141.830 168.274 1.00 51.35  ? 443 VAL B N   1 
ATOM   2542 C CA  . VAL A 1 443 ? 149.521 141.359 167.243 1.00 51.35  ? 443 VAL B CA  1 
ATOM   2543 C C   . VAL A 1 443 ? 150.923 141.923 167.452 1.00 51.35  ? 443 VAL B C   1 
ATOM   2544 O O   . VAL A 1 443 ? 151.915 141.187 167.405 1.00 51.35  ? 443 VAL B O   1 
ATOM   2545 C CB  . VAL A 1 443 ? 148.982 141.704 165.845 1.00 51.35  ? 443 VAL B CB  1 
ATOM   2546 C CG1 . VAL A 1 443 ? 149.988 141.311 164.777 1.00 51.35  ? 443 VAL B CG1 1 
ATOM   2547 C CG2 . VAL A 1 443 ? 147.649 141.021 165.605 1.00 51.35  ? 443 VAL B CG2 1 
ATOM   2548 N N   . ASP A 1 444 ? 151.029 143.229 167.682 1.00 53.89  ? 444 ASP B N   1 
ATOM   2549 C CA  . ASP A 1 444 ? 152.332 143.878 167.647 1.00 53.89  ? 444 ASP B CA  1 
ATOM   2550 C C   . ASP A 1 444 ? 153.211 143.459 168.822 1.00 53.89  ? 444 ASP B C   1 
ATOM   2551 O O   . ASP A 1 444 ? 152.727 143.085 169.894 1.00 53.89  ? 444 ASP B O   1 
ATOM   2552 C CB  . ASP A 1 444 ? 152.171 145.400 167.597 1.00 53.89  ? 444 ASP B CB  1 
ATOM   2553 C CG  . ASP A 1 444 ? 151.276 145.942 168.693 1.00 53.89  ? 444 ASP B CG  1 
ATOM   2554 O OD1 . ASP A 1 444 ? 150.518 146.889 168.403 1.00 53.89  ? 444 ASP B OD1 1 
ATOM   2555 O OD2 . ASP A 1 444 ? 151.320 145.440 169.833 1.00 53.89  ? 444 ASP B OD2 1 
ATOM   2556 N N   . ALA A 1 445 ? 154.527 143.502 168.592 1.00 54.05  ? 445 ALA B N   1 
ATOM   2557 C CA  . ALA A 1 445 ? 155.494 143.119 169.613 1.00 54.05  ? 445 ALA B CA  1 
ATOM   2558 C C   . ALA A 1 445 ? 155.629 144.167 170.707 1.00 54.05  ? 445 ALA B C   1 
ATOM   2559 O O   . ALA A 1 445 ? 156.154 143.859 171.782 1.00 54.05  ? 445 ALA B O   1 
ATOM   2560 C CB  . ALA A 1 445 ? 156.859 142.858 168.975 1.00 54.05  ? 445 ALA B CB  1 
ATOM   2561 N N   . SER A 1 446 ? 155.188 145.399 170.453 1.00 61.81  ? 446 SER B N   1 
ATOM   2562 C CA  . SER A 1 446 ? 155.228 146.428 171.484 1.00 61.81  ? 446 SER B CA  1 
ATOM   2563 C C   . SER A 1 446 ? 154.104 146.267 172.501 1.00 61.81  ? 446 SER B C   1 
ATOM   2564 O O   . SER A 1 446 ? 154.269 146.649 173.664 1.00 61.81  ? 446 SER B O   1 
ATOM   2565 C CB  . SER A 1 446 ? 155.165 147.812 170.840 1.00 61.81  ? 446 SER B CB  1 
ATOM   2566 O OG  . SER A 1 446 ? 156.306 148.043 170.034 1.00 61.81  ? 446 SER B OG  1 
ATOM   2567 N N   . GLY A 1 447 ? 152.968 145.709 172.091 1.00 57.84  ? 447 GLY B N   1 
ATOM   2568 C CA  . GLY A 1 447 ? 151.852 145.518 172.997 1.00 57.84  ? 447 GLY B CA  1 
ATOM   2569 C C   . GLY A 1 447 ? 151.962 144.232 173.786 1.00 57.84  ? 447 GLY B C   1 
ATOM   2570 O O   . GLY A 1 447 ? 153.004 143.962 174.390 1.00 57.84  ? 447 GLY B O   1 
ATOM   2571 N N   . LEU A 1 448 ? 150.892 143.433 173.804 1.00 58.71  ? 448 LEU B N   1 
ATOM   2572 C CA  . LEU A 1 448 ? 150.963 142.135 174.469 1.00 58.71  ? 448 LEU B CA  1 
ATOM   2573 C C   . LEU A 1 448 ? 151.838 141.163 173.689 1.00 58.71  ? 448 LEU B C   1 
ATOM   2574 O O   . LEU A 1 448 ? 152.661 140.452 174.277 1.00 58.71  ? 448 LEU B O   1 
ATOM   2575 C CB  . LEU A 1 448 ? 149.560 141.556 174.671 1.00 58.71  ? 448 LEU B CB  1 
ATOM   2576 C CG  . LEU A 1 448 ? 148.782 142.012 175.910 1.00 58.71  ? 448 LEU B CG  1 
ATOM   2577 C CD1 . LEU A 1 448 ? 148.284 143.440 175.770 1.00 58.71  ? 448 LEU B CD1 1 
ATOM   2578 C CD2 . LEU A 1 448 ? 147.628 141.067 176.202 1.00 58.71  ? 448 LEU B CD2 1 
ATOM   2579 N N   . GLY A 1 449 ? 151.686 141.128 172.369 1.00 60.46  ? 449 GLY B N   1 
ATOM   2580 C CA  . GLY A 1 449 ? 152.508 140.253 171.550 1.00 60.46  ? 449 GLY B CA  1 
ATOM   2581 C C   . GLY A 1 449 ? 152.315 138.781 171.838 1.00 60.46  ? 449 GLY B C   1 
ATOM   2582 O O   . GLY A 1 449 ? 153.299 138.038 171.943 1.00 60.46  ? 449 GLY B O   1 
ATOM   2583 N N   . LEU A 1 450 ? 151.066 138.342 171.977 1.00 62.95  ? 450 LEU B N   1 
ATOM   2584 C CA  . LEU A 1 450 ? 150.792 136.942 172.264 1.00 62.95  ? 450 LEU B CA  1 
ATOM   2585 C C   . LEU A 1 450 ? 151.191 136.060 171.088 1.00 62.95  ? 450 LEU B C   1 
ATOM   2586 O O   . LEU A 1 450 ? 151.136 136.470 169.925 1.00 62.95  ? 450 LEU B O   1 
ATOM   2587 C CB  . LEU A 1 450 ? 149.313 136.740 172.594 1.00 62.95  ? 450 LEU B CB  1 
ATOM   2588 C CG  . LEU A 1 450 ? 148.861 137.247 173.965 1.00 62.95  ? 450 LEU B CG  1 
ATOM   2589 C CD1 . LEU A 1 450 ? 147.381 136.983 174.171 1.00 62.95  ? 450 LEU B CD1 1 
ATOM   2590 C CD2 . LEU A 1 450 ? 149.681 136.606 175.074 1.00 62.95  ? 450 LEU B CD2 1 
ATOM   2591 N N   . GLU A 1 451 ? 151.600 134.835 171.408 1.00 55.00  ? 451 GLU B N   1 
ATOM   2592 C CA  . GLU A 1 451 ? 152.080 133.910 170.392 1.00 55.00  ? 451 GLU B CA  1 
ATOM   2593 C C   . GLU A 1 451 ? 150.978 133.594 169.390 1.00 55.00  ? 451 GLU B C   1 
ATOM   2594 O O   . GLU A 1 451 ? 149.793 133.540 169.729 1.00 55.00  ? 451 GLU B O   1 
ATOM   2595 C CB  . GLU A 1 451 ? 152.581 132.620 171.045 1.00 55.00  ? 451 GLU B CB  1 
ATOM   2596 C CG  . GLU A 1 451 ? 154.049 132.642 171.441 1.00 55.00  ? 451 GLU B CG  1 
ATOM   2597 C CD  . GLU A 1 451 ? 154.974 132.243 170.306 1.00 55.00  ? 451 GLU B CD  1 
ATOM   2598 O OE1 . GLU A 1 451 ? 156.131 131.868 170.590 1.00 55.00  ? 451 GLU B OE1 1 
ATOM   2599 O OE2 . GLU A 1 451 ? 154.549 132.298 169.134 1.00 55.00  ? 451 GLU B OE2 1 
ATOM   2600 N N   . ILE A 1 452 ? 151.385 133.389 168.135 1.00 48.70  ? 452 ILE B N   1 
ATOM   2601 C CA  . ILE A 1 452 ? 150.426 133.126 167.067 1.00 48.70  ? 452 ILE B CA  1 
ATOM   2602 C C   . ILE A 1 452 ? 149.657 131.839 167.328 1.00 48.70  ? 452 ILE B C   1 
ATOM   2603 O O   . ILE A 1 452 ? 148.474 131.732 166.982 1.00 48.70  ? 452 ILE B O   1 
ATOM   2604 C CB  . ILE A 1 452 ? 151.153 133.098 165.707 1.00 48.70  ? 452 ILE B CB  1 
ATOM   2605 C CG1 . ILE A 1 452 ? 150.181 132.743 164.584 1.00 48.70  ? 452 ILE B CG1 1 
ATOM   2606 C CG2 . ILE A 1 452 ? 152.328 132.135 165.741 1.00 48.70  ? 452 ILE B CG2 1 
ATOM   2607 C CD1 . ILE A 1 452 ? 149.087 133.751 164.407 1.00 48.70  ? 452 ILE B CD1 1 
ATOM   2608 N N   . THR A 1 453 ? 150.302 130.851 167.952 1.00 45.01  ? 453 THR B N   1 
ATOM   2609 C CA  . THR A 1 453 ? 149.635 129.582 168.217 1.00 45.01  ? 453 THR B CA  1 
ATOM   2610 C C   . THR A 1 453 ? 148.431 129.772 169.128 1.00 45.01  ? 453 THR B C   1 
ATOM   2611 O O   . THR A 1 453 ? 147.360 129.206 168.882 1.00 45.01  ? 453 THR B O   1 
ATOM   2612 C CB  . THR A 1 453 ? 150.620 128.593 168.841 1.00 45.01  ? 453 THR B CB  1 
ATOM   2613 O OG1 . THR A 1 453 ? 151.703 128.356 167.933 1.00 45.01  ? 453 THR B OG1 1 
ATOM   2614 C CG2 . THR A 1 453 ? 149.933 127.272 169.146 1.00 45.01  ? 453 THR B CG2 1 
ATOM   2615 N N   . THR A 1 454 ? 148.577 130.588 170.165 1.00 48.45  ? 454 THR B N   1 
ATOM   2616 C CA  . THR A 1 454 ? 147.561 130.728 171.195 1.00 48.45  ? 454 THR B CA  1 
ATOM   2617 C C   . THR A 1 454 ? 146.581 131.866 170.925 1.00 48.45  ? 454 THR B C   1 
ATOM   2618 O O   . THR A 1 454 ? 145.832 132.248 171.830 1.00 48.45  ? 454 THR B O   1 
ATOM   2619 C CB  . THR A 1 454 ? 148.229 130.924 172.556 1.00 48.45  ? 454 THR B CB  1 
ATOM   2620 O OG1 . THR A 1 454 ? 149.247 131.925 172.448 1.00 48.45  ? 454 THR B OG1 1 
ATOM   2621 C CG2 . THR A 1 454 ? 148.857 129.623 173.027 1.00 48.45  ? 454 THR B CG2 1 
ATOM   2622 N N   . GLN A 1 455 ? 146.568 132.419 169.715 1.00 46.11  ? 455 GLN B N   1 
ATOM   2623 C CA  . GLN A 1 455 ? 145.646 133.500 169.394 1.00 46.11  ? 455 GLN B CA  1 
ATOM   2624 C C   . GLN A 1 455 ? 144.305 133.011 168.868 1.00 46.11  ? 455 GLN B C   1 
ATOM   2625 O O   . GLN A 1 455 ? 143.382 133.822 168.730 1.00 46.11  ? 455 GLN B O   1 
ATOM   2626 C CB  . GLN A 1 455 ? 146.275 134.447 168.368 1.00 46.11  ? 455 GLN B CB  1 
ATOM   2627 C CG  . GLN A 1 455 ? 146.130 134.001 166.925 1.00 46.11  ? 455 GLN B CG  1 
ATOM   2628 C CD  . GLN A 1 455 ? 146.348 135.137 165.947 1.00 46.11  ? 455 GLN B CD  1 
ATOM   2629 O OE1 . GLN A 1 455 ? 147.193 136.004 166.163 1.00 46.11  ? 455 GLN B OE1 1 
ATOM   2630 N NE2 . GLN A 1 455 ? 145.586 135.136 164.863 1.00 46.11  ? 455 GLN B NE2 1 
ATOM   2631 N N   . PHE A 1 456 ? 144.170 131.721 168.570 1.00 40.14  ? 456 PHE B N   1 
ATOM   2632 C CA  . PHE A 1 456 ? 142.937 131.177 168.014 1.00 40.14  ? 456 PHE B CA  1 
ATOM   2633 C C   . PHE A 1 456 ? 142.024 130.548 169.062 1.00 40.14  ? 456 PHE B C   1 
ATOM   2634 O O   . PHE A 1 456 ? 140.959 130.038 168.702 1.00 40.14  ? 456 PHE B O   1 
ATOM   2635 C CB  . PHE A 1 456 ? 143.262 130.142 166.932 1.00 40.14  ? 456 PHE B CB  1 
ATOM   2636 C CG  . PHE A 1 456 ? 143.613 130.741 165.602 1.00 40.14  ? 456 PHE B CG  1 
ATOM   2637 C CD1 . PHE A 1 456 ? 143.385 132.080 165.346 1.00 40.14  ? 456 PHE B CD1 1 
ATOM   2638 C CD2 . PHE A 1 456 ? 144.172 129.959 164.603 1.00 40.14  ? 456 PHE B CD2 1 
ATOM   2639 C CE1 . PHE A 1 456 ? 143.707 132.627 164.121 1.00 40.14  ? 456 PHE B CE1 1 
ATOM   2640 C CE2 . PHE A 1 456 ? 144.496 130.502 163.376 1.00 40.14  ? 456 PHE B CE2 1 
ATOM   2641 C CZ  . PHE A 1 456 ? 144.264 131.836 163.135 1.00 40.14  ? 456 PHE B CZ  1 
ATOM   2642 N N   . LEU A 1 457 ? 142.411 130.560 170.339 1.00 45.56  ? 457 LEU B N   1 
ATOM   2643 C CA  . LEU A 1 457 ? 141.566 129.972 171.375 1.00 45.56  ? 457 LEU B CA  1 
ATOM   2644 C C   . LEU A 1 457 ? 140.315 130.813 171.610 1.00 45.56  ? 457 LEU B C   1 
ATOM   2645 O O   . LEU A 1 457 ? 139.189 130.358 171.374 1.00 45.56  ? 457 LEU B O   1 
ATOM   2646 C CB  . LEU A 1 457 ? 142.357 129.818 172.678 1.00 45.56  ? 457 LEU B CB  1 
ATOM   2647 C CG  . LEU A 1 457 ? 143.084 128.502 172.971 1.00 45.56  ? 457 LEU B CG  1 
ATOM   2648 C CD1 . LEU A 1 457 ? 144.337 128.351 172.126 1.00 45.56  ? 457 LEU B CD1 1 
ATOM   2649 C CD2 . LEU A 1 457 ? 143.417 128.397 174.451 1.00 45.56  ? 457 LEU B CD2 1 
ATOM   2650 N N   . ILE A 1 458 ? 140.497 132.051 172.075 1.00 46.90  ? 458 ILE B N   1 
ATOM   2651 C CA  . ILE A 1 458 ? 139.374 132.947 172.335 1.00 46.90  ? 458 ILE B CA  1 
ATOM   2652 C C   . ILE A 1 458 ? 138.639 133.309 171.048 1.00 46.90  ? 458 ILE B C   1 
ATOM   2653 O O   . ILE A 1 458 ? 137.448 133.638 171.090 1.00 46.90  ? 458 ILE B O   1 
ATOM   2654 C CB  . ILE A 1 458 ? 139.876 134.196 173.106 1.00 46.90  ? 458 ILE B CB  1 
ATOM   2655 C CG1 . ILE A 1 458 ? 140.374 133.823 174.510 1.00 46.90  ? 458 ILE B CG1 1 
ATOM   2656 C CG2 . ILE A 1 458 ? 138.815 135.277 173.230 1.00 46.90  ? 458 ILE B CG2 1 
ATOM   2657 C CD1 . ILE A 1 458 ? 141.851 133.507 174.612 1.00 46.90  ? 458 ILE B CD1 1 
ATOM   2658 N N   . TYR A 1 459 ? 139.302 133.192 169.892 1.00 46.91  ? 459 TYR B N   1 
ATOM   2659 C CA  . TYR A 1 459 ? 138.721 133.671 168.639 1.00 46.91  ? 459 TYR B CA  1 
ATOM   2660 C C   . TYR A 1 459 ? 137.414 132.966 168.293 1.00 46.91  ? 459 TYR B C   1 
ATOM   2661 O O   . TYR A 1 459 ? 136.595 133.518 167.549 1.00 46.91  ? 459 TYR B O   1 
ATOM   2662 C CB  . TYR A 1 459 ? 139.727 133.513 167.500 1.00 46.91  ? 459 TYR B CB  1 
ATOM   2663 C CG  . TYR A 1 459 ? 140.668 134.685 167.377 1.00 46.91  ? 459 TYR B CG  1 
ATOM   2664 C CD1 . TYR A 1 459 ? 140.766 135.625 168.395 1.00 46.91  ? 459 TYR B CD1 1 
ATOM   2665 C CD2 . TYR A 1 459 ? 141.448 134.863 166.243 1.00 46.91  ? 459 TYR B CD2 1 
ATOM   2666 C CE1 . TYR A 1 459 ? 141.620 136.702 168.293 1.00 46.91  ? 459 TYR B CE1 1 
ATOM   2667 C CE2 . TYR A 1 459 ? 142.307 135.941 166.130 1.00 46.91  ? 459 TYR B CE2 1 
ATOM   2668 C CZ  . TYR A 1 459 ? 142.387 136.857 167.159 1.00 46.91  ? 459 TYR B CZ  1 
ATOM   2669 O OH  . TYR A 1 459 ? 143.237 137.934 167.063 1.00 46.91  ? 459 TYR B OH  1 
ATOM   2670 N N   . ALA A 1 460 ? 137.199 131.753 168.807 1.00 51.99  ? 460 ALA B N   1 
ATOM   2671 C CA  . ALA A 1 460 ? 135.891 131.123 168.654 1.00 51.99  ? 460 ALA B CA  1 
ATOM   2672 C C   . ALA A 1 460 ? 134.819 131.916 169.388 1.00 51.99  ? 460 ALA B C   1 
ATOM   2673 O O   . ALA A 1 460 ? 133.720 132.120 168.862 1.00 51.99  ? 460 ALA B O   1 
ATOM   2674 C CB  . ALA A 1 460 ? 135.927 129.682 169.155 1.00 51.99  ? 460 ALA B CB  1 
ATOM   2675 N N   . SER A 1 461 ? 135.122 132.375 170.607 1.00 56.00  ? 461 SER B N   1 
ATOM   2676 C CA  . SER A 1 461 ? 134.204 133.253 171.324 1.00 56.00  ? 461 SER B CA  1 
ATOM   2677 C C   . SER A 1 461 ? 134.137 134.634 170.688 1.00 56.00  ? 461 SER B C   1 
ATOM   2678 O O   . SER A 1 461 ? 133.082 135.275 170.722 1.00 56.00  ? 461 SER B O   1 
ATOM   2679 C CB  . SER A 1 461 ? 134.616 133.371 172.791 1.00 56.00  ? 461 SER B CB  1 
ATOM   2680 O OG  . SER A 1 461 ? 135.983 133.715 172.905 1.00 56.00  ? 461 SER B OG  1 
ATOM   2681 N N   . TYR A 1 462 ? 135.247 135.106 170.119 1.00 58.19  ? 462 TYR B N   1 
ATOM   2682 C CA  . TYR A 1 462 ? 135.207 136.316 169.306 1.00 58.19  ? 462 TYR B CA  1 
ATOM   2683 C C   . TYR A 1 462 ? 134.287 136.130 168.107 1.00 58.19  ? 462 TYR B C   1 
ATOM   2684 O O   . TYR A 1 462 ? 133.501 137.023 167.771 1.00 58.19  ? 462 TYR B O   1 
ATOM   2685 C CB  . TYR A 1 462 ? 136.628 136.689 168.872 1.00 58.19  ? 462 TYR B CB  1 
ATOM   2686 C CG  . TYR A 1 462 ? 136.729 137.586 167.657 1.00 58.19  ? 462 TYR B CG  1 
ATOM   2687 C CD1 . TYR A 1 462 ? 136.801 138.965 167.790 1.00 58.19  ? 462 TYR B CD1 1 
ATOM   2688 C CD2 . TYR A 1 462 ? 136.813 137.047 166.378 1.00 58.19  ? 462 TYR B CD2 1 
ATOM   2689 C CE1 . TYR A 1 462 ? 136.908 139.782 166.682 1.00 58.19  ? 462 TYR B CE1 1 
ATOM   2690 C CE2 . TYR A 1 462 ? 136.920 137.855 165.269 1.00 58.19  ? 462 TYR B CE2 1 
ATOM   2691 C CZ  . TYR A 1 462 ? 136.969 139.219 165.426 1.00 58.19  ? 462 TYR B CZ  1 
ATOM   2692 O OH  . TYR A 1 462 ? 137.081 140.018 164.316 1.00 58.19  ? 462 TYR B OH  1 
ATOM   2693 N N   . PHE A 1 463 ? 134.368 134.970 167.451 1.00 56.75  ? 463 PHE B N   1 
ATOM   2694 C CA  . PHE A 1 463 ? 133.406 134.651 166.404 1.00 56.75  ? 463 PHE B CA  1 
ATOM   2695 C C   . PHE A 1 463 ? 132.029 134.355 166.987 1.00 56.75  ? 463 PHE B C   1 
ATOM   2696 O O   . PHE A 1 463 ? 131.027 134.422 166.268 1.00 56.75  ? 463 PHE B O   1 
ATOM   2697 C CB  . PHE A 1 463 ? 133.898 133.464 165.579 1.00 56.75  ? 463 PHE B CB  1 
ATOM   2698 C CG  . PHE A 1 463 ? 134.709 133.854 164.379 1.00 56.75  ? 463 PHE B CG  1 
ATOM   2699 C CD1 . PHE A 1 463 ? 134.227 134.779 163.471 1.00 56.75  ? 463 PHE B CD1 1 
ATOM   2700 C CD2 . PHE A 1 463 ? 135.952 133.288 164.155 1.00 56.75  ? 463 PHE B CD2 1 
ATOM   2701 C CE1 . PHE A 1 463 ? 134.972 135.138 162.366 1.00 56.75  ? 463 PHE B CE1 1 
ATOM   2702 C CE2 . PHE A 1 463 ? 136.701 133.641 163.051 1.00 56.75  ? 463 PHE B CE2 1 
ATOM   2703 C CZ  . PHE A 1 463 ? 136.210 134.567 162.156 1.00 56.75  ? 463 PHE B CZ  1 
ATOM   2704 N N   . ALA A 1 464 ? 131.960 134.016 168.275 1.00 68.78  ? 464 ALA B N   1 
ATOM   2705 C CA  . ALA A 1 464 ? 130.675 133.782 168.922 1.00 68.78  ? 464 ALA B CA  1 
ATOM   2706 C C   . ALA A 1 464 ? 130.102 135.038 169.561 1.00 68.78  ? 464 ALA B C   1 
ATOM   2707 O O   . ALA A 1 464 ? 128.879 135.131 169.713 1.00 68.78  ? 464 ALA B O   1 
ATOM   2708 C CB  . ALA A 1 464 ? 130.801 132.686 169.981 1.00 68.78  ? 464 ALA B CB  1 
ATOM   2709 N N   . LEU A 1 465 ? 130.949 135.998 169.941 1.00 81.64  ? 465 LEU B N   1 
ATOM   2710 C CA  . LEU A 1 465 ? 130.445 137.240 170.520 1.00 81.64  ? 465 LEU B CA  1 
ATOM   2711 C C   . LEU A 1 465 ? 129.584 137.997 169.520 1.00 81.64  ? 465 LEU B C   1 
ATOM   2712 O O   . LEU A 1 465 ? 128.550 138.567 169.889 1.00 81.64  ? 465 LEU B O   1 
ATOM   2713 C CB  . LEU A 1 465 ? 131.605 138.115 170.994 1.00 81.64  ? 465 LEU B CB  1 
ATOM   2714 C CG  . LEU A 1 465 ? 131.268 139.204 172.016 1.00 81.64  ? 465 LEU B CG  1 
ATOM   2715 C CD1 . LEU A 1 465 ? 130.836 138.588 173.340 1.00 81.64  ? 465 LEU B CD1 1 
ATOM   2716 C CD2 . LEU A 1 465 ? 132.449 140.148 172.213 1.00 81.64  ? 465 LEU B CD2 1 
ATOM   2717 N N   . ILE A 1 466 ? 129.998 138.019 168.252 1.00 79.65  ? 466 ILE B N   1 
ATOM   2718 C CA  . ILE A 1 466 ? 129.171 138.625 167.217 1.00 79.65  ? 466 ILE B CA  1 
ATOM   2719 C C   . ILE A 1 466 ? 127.890 137.822 167.021 1.00 79.65  ? 466 ILE B C   1 
ATOM   2720 O O   . ILE A 1 466 ? 126.857 138.373 166.622 1.00 79.65  ? 466 ILE B O   1 
ATOM   2721 C CB  . ILE A 1 466 ? 129.974 138.767 165.911 1.00 79.65  ? 466 ILE B CB  1 
ATOM   2722 C CG1 . ILE A 1 466 ? 129.218 139.637 164.905 1.00 79.65  ? 466 ILE B CG1 1 
ATOM   2723 C CG2 . ILE A 1 466 ? 130.313 137.408 165.320 1.00 79.65  ? 466 ILE B CG2 1 
ATOM   2724 C CD1 . ILE A 1 466 ? 128.861 141.009 165.433 1.00 79.65  ? 466 ILE B CD1 1 
ATOM   2725 N N   . ALA A 1 467 ? 127.930 136.515 167.297 1.00 83.54  ? 467 ALA B N   1 
ATOM   2726 C CA  . ALA A 1 467 ? 126.711 135.717 167.261 1.00 83.54  ? 467 ALA B CA  1 
ATOM   2727 C C   . ALA A 1 467 ? 125.851 135.973 168.491 1.00 83.54  ? 467 ALA B C   1 
ATOM   2728 O O   . ALA A 1 467 ? 124.619 135.938 168.409 1.00 83.54  ? 467 ALA B O   1 
ATOM   2729 C CB  . ALA A 1 467 ? 127.055 134.233 167.147 1.00 83.54  ? 467 ALA B CB  1 
ATOM   2730 N N   . VAL A 1 468 ? 126.483 136.227 169.639 1.00 96.33  ? 468 VAL B N   1 
ATOM   2731 C CA  . VAL A 1 468 ? 125.731 136.498 170.860 1.00 96.33  ? 468 VAL B CA  1 
ATOM   2732 C C   . VAL A 1 468 ? 124.937 137.792 170.723 1.00 96.33  ? 468 VAL B C   1 
ATOM   2733 O O   . VAL A 1 468 ? 123.738 137.835 171.022 1.00 96.33  ? 468 VAL B O   1 
ATOM   2734 C CB  . VAL A 1 468 ? 126.674 136.538 172.077 1.00 96.33  ? 468 VAL B CB  1 
ATOM   2735 C CG1 . VAL A 1 468 ? 125.972 137.161 173.273 1.00 96.33  ? 468 VAL B CG1 1 
ATOM   2736 C CG2 . VAL A 1 468 ? 127.155 135.134 172.422 1.00 96.33  ? 468 VAL B CG2 1 
ATOM   2737 N N   . VAL A 1 469 ? 125.589 138.862 170.260 1.00 97.96  ? 469 VAL B N   1 
ATOM   2738 C CA  . VAL A 1 469 ? 124.882 140.125 170.064 1.00 97.96  ? 469 VAL B CA  1 
ATOM   2739 C C   . VAL A 1 469 ? 123.850 139.993 168.949 1.00 97.96  ? 469 VAL B C   1 
ATOM   2740 O O   . VAL A 1 469 ? 122.772 140.596 169.019 1.00 97.96  ? 469 VAL B O   1 
ATOM   2741 C CB  . VAL A 1 469 ? 125.880 141.273 169.802 1.00 97.96  ? 469 VAL B CB  1 
ATOM   2742 C CG1 . VAL A 1 469 ? 126.695 141.024 168.542 1.00 97.96  ? 469 VAL B CG1 1 
ATOM   2743 C CG2 . VAL A 1 469 ? 125.155 142.608 169.721 1.00 97.96  ? 469 VAL B CG2 1 
ATOM   2744 N N   . PHE A 1 470 ? 124.151 139.204 167.913 1.00 97.69  ? 470 PHE B N   1 
ATOM   2745 C CA  . PHE A 1 470 ? 123.136 138.876 166.917 1.00 97.69  ? 470 PHE B CA  1 
ATOM   2746 C C   . PHE A 1 470 ? 121.994 138.094 167.548 1.00 97.69  ? 470 PHE B C   1 
ATOM   2747 O O   . PHE A 1 470 ? 120.820 138.340 167.248 1.00 97.69  ? 470 PHE B O   1 
ATOM   2748 C CB  . PHE A 1 470 ? 123.757 138.082 165.769 1.00 97.69  ? 470 PHE B CB  1 
ATOM   2749 N N   . LEU A 1 471 ? 122.321 137.141 168.424 1.00 108.78 ? 471 LEU B N   1 
ATOM   2750 C CA  . LEU A 1 471 ? 121.281 136.456 169.182 1.00 108.78 ? 471 LEU B CA  1 
ATOM   2751 C C   . LEU A 1 471 ? 120.638 137.382 170.204 1.00 108.78 ? 471 LEU B C   1 
ATOM   2752 O O   . LEU A 1 471 ? 119.435 137.272 170.460 1.00 108.78 ? 471 LEU B O   1 
ATOM   2753 C CB  . LEU A 1 471 ? 121.849 135.216 169.871 1.00 108.78 ? 471 LEU B CB  1 
ATOM   2754 C CG  . LEU A 1 471 ? 120.814 134.156 170.256 1.00 108.78 ? 471 LEU B CG  1 
ATOM   2755 C CD1 . LEU A 1 471 ? 120.041 133.694 169.031 1.00 108.78 ? 471 LEU B CD1 1 
ATOM   2756 C CD2 . LEU A 1 471 ? 121.478 132.977 170.945 1.00 108.78 ? 471 LEU B CD2 1 
ATOM   2757 N N   . ALA A 1 472 ? 121.418 138.289 170.804 1.00 112.56 ? 472 ALA B N   1 
ATOM   2758 C CA  . ALA A 1 472 ? 120.833 139.287 171.695 1.00 112.56 ? 472 ALA B CA  1 
ATOM   2759 C C   . ALA A 1 472 ? 119.857 140.181 170.943 1.00 112.56 ? 472 ALA B C   1 
ATOM   2760 O O   . ALA A 1 472 ? 118.751 140.453 171.424 1.00 112.56 ? 472 ALA B O   1 
ATOM   2761 C CB  . ALA A 1 472 ? 121.932 140.122 172.352 1.00 112.56 ? 472 ALA B CB  1 
ATOM   2762 N N   . SER A 1 473 ? 120.250 140.646 169.755 1.00 115.51 ? 473 SER B N   1 
ATOM   2763 C CA  . SER A 1 473 ? 119.295 141.304 168.874 1.00 115.51 ? 473 SER B CA  1 
ATOM   2764 C C   . SER A 1 473 ? 118.223 140.330 168.410 1.00 115.51 ? 473 SER B C   1 
ATOM   2765 O O   . SER A 1 473 ? 117.066 140.723 168.224 1.00 115.51 ? 473 SER B O   1 
ATOM   2766 C CB  . SER A 1 473 ? 120.018 141.918 167.675 1.00 115.51 ? 473 SER B CB  1 
ATOM   2767 O OG  . SER A 1 473 ? 119.101 142.287 166.661 1.00 115.51 ? 473 SER B OG  1 
ATOM   2768 N N   . GLY A 1 474 ? 118.590 139.063 168.213 1.00 121.62 ? 474 GLY B N   1 
ATOM   2769 C CA  . GLY A 1 474 ? 117.592 138.053 167.910 1.00 121.62 ? 474 GLY B CA  1 
ATOM   2770 C C   . GLY A 1 474 ? 116.660 137.784 169.076 1.00 121.62 ? 474 GLY B C   1 
ATOM   2771 O O   . GLY A 1 474 ? 115.466 137.547 168.880 1.00 121.62 ? 474 GLY B O   1 
ATOM   2772 N N   . ALA A 1 475 ? 117.192 137.809 170.303 1.00 124.31 ? 475 ALA B N   1 
ATOM   2773 C CA  . ALA A 1 475 ? 116.364 137.547 171.477 1.00 124.31 ? 475 ALA B CA  1 
ATOM   2774 C C   . ALA A 1 475 ? 115.280 138.604 171.639 1.00 124.31 ? 475 ALA B C   1 
ATOM   2775 O O   . ALA A 1 475 ? 114.124 138.277 171.933 1.00 124.31 ? 475 ALA B O   1 
ATOM   2776 C CB  . ALA A 1 475 ? 117.231 137.477 172.733 1.00 124.31 ? 475 ALA B CB  1 
ATOM   2777 N N   . VAL A 1 476 ? 115.635 139.878 171.459 1.00 127.08 ? 476 VAL B N   1 
ATOM   2778 C CA  . VAL A 1 476 ? 114.622 140.928 171.429 1.00 127.08 ? 476 VAL B CA  1 
ATOM   2779 C C   . VAL A 1 476 ? 113.693 140.722 170.240 1.00 127.08 ? 476 VAL B C   1 
ATOM   2780 O O   . VAL A 1 476 ? 112.472 140.890 170.349 1.00 127.08 ? 476 VAL B O   1 
ATOM   2781 C CB  . VAL A 1 476 ? 115.286 142.317 171.399 1.00 127.08 ? 476 VAL B CB  1 
ATOM   2782 N N   . SER A 1 477 ? 114.257 140.352 169.087 1.00 124.50 ? 477 SER B N   1 
ATOM   2783 C CA  . SER A 1 477 ? 113.431 140.009 167.936 1.00 124.50 ? 477 SER B CA  1 
ATOM   2784 C C   . SER A 1 477 ? 112.556 138.799 168.234 1.00 124.50 ? 477 SER B C   1 
ATOM   2785 O O   . SER A 1 477 ? 111.378 138.769 167.860 1.00 124.50 ? 477 SER B O   1 
ATOM   2786 C CB  . SER A 1 477 ? 114.313 139.749 166.715 1.00 124.50 ? 477 SER B CB  1 
ATOM   2787 N N   . VAL A 1 478 ? 113.113 137.792 168.911 1.00 129.00 ? 478 VAL B N   1 
ATOM   2788 C CA  . VAL A 1 478 ? 112.312 136.647 169.334 1.00 129.00 ? 478 VAL B CA  1 
ATOM   2789 C C   . VAL A 1 478 ? 111.281 137.075 170.370 1.00 129.00 ? 478 VAL B C   1 
ATOM   2790 O O   . VAL A 1 478 ? 110.170 136.534 170.421 1.00 129.00 ? 478 VAL B O   1 
ATOM   2791 C CB  . VAL A 1 478 ? 113.216 135.522 169.867 1.00 129.00 ? 478 VAL B CB  1 
ATOM   2792 N N   . MET A 1 479 ? 111.637 138.037 171.223 1.00 128.45 ? 479 MET B N   1 
ATOM   2793 C CA  . MET A 1 479 ? 110.664 138.582 172.164 1.00 128.45 ? 479 MET B CA  1 
ATOM   2794 C C   . MET A 1 479 ? 109.534 139.293 171.431 1.00 128.45 ? 479 MET B C   1 
ATOM   2795 O O   . MET A 1 479 ? 108.369 139.209 171.838 1.00 128.45 ? 479 MET B O   1 
ATOM   2796 C CB  . MET A 1 479 ? 111.353 139.536 173.139 1.00 128.45 ? 479 MET B CB  1 
ATOM   2797 N N   . LYS A 1 480 ? 109.860 140.001 170.353 1.00 125.46 ? 480 LYS B N   1 
ATOM   2798 C CA  . LYS A 1 480 ? 108.868 140.731 169.577 1.00 125.46 ? 480 LYS B CA  1 
ATOM   2799 C C   . LYS A 1 480 ? 108.277 139.919 168.431 1.00 125.46 ? 480 LYS B C   1 
ATOM   2800 O O   . LYS A 1 480 ? 107.345 140.397 167.775 1.00 125.46 ? 480 LYS B O   1 
ATOM   2801 C CB  . LYS A 1 480 ? 109.481 142.020 169.020 1.00 125.46 ? 480 LYS B CB  1 
ATOM   2802 N N   . LYS A 1 481 ? 108.791 138.716 168.167 1.00 126.71 ? 481 LYS B N   1 
ATOM   2803 C CA  . LYS A 1 481 ? 108.274 137.923 167.056 1.00 126.71 ? 481 LYS B CA  1 
ATOM   2804 C C   . LYS A 1 481 ? 106.855 137.440 167.331 1.00 126.71 ? 481 LYS B C   1 
ATOM   2805 O O   . LYS A 1 481 ? 105.965 137.586 166.485 1.00 126.71 ? 481 LYS B O   1 
ATOM   2806 C CB  . LYS A 1 481 ? 109.199 136.738 166.780 1.00 126.71 ? 481 LYS B CB  1 
ATOM   2807 N N   . CYS A 1 482 ? 106.623 136.867 168.514 1.00 123.65 ? 482 CYS B N   1 
ATOM   2808 C CA  . CYS A 1 482 ? 105.308 136.315 168.825 1.00 123.65 ? 482 CYS B CA  1 
ATOM   2809 C C   . CYS A 1 482 ? 104.258 137.408 168.992 1.00 123.65 ? 482 CYS B C   1 
ATOM   2810 O O   . CYS A 1 482 ? 103.081 137.183 168.691 1.00 123.65 ? 482 CYS B O   1 
ATOM   2811 C CB  . CYS A 1 482 ? 105.385 135.451 170.084 1.00 123.65 ? 482 CYS B CB  1 
ATOM   2812 N N   . ARG A 1 483 ? 104.658 138.582 169.472 1.00 120.36 ? 483 ARG B N   1 
ATOM   2813 C CA  . ARG A 1 483 ? 103.736 139.700 169.649 1.00 120.36 ? 483 ARG B CA  1 
ATOM   2814 C C   . ARG A 1 483 ? 104.284 140.967 169.002 1.00 120.36 ? 483 ARG B C   1 
ATOM   2815 O O   . ARG A 1 483 ? 103.822 141.383 167.939 1.00 120.36 ? 483 ARG B O   1 
ATOM   2816 C CB  . ARG A 1 483 ? 103.465 139.945 171.135 1.00 120.36 ? 483 ARG B CB  1 
HETATM 2817 O OP4 . UEG B 2 .   ? 151.271 139.420 153.879 1.00 47.37  ? 501 UEG B OP4 1 
HETATM 2818 C C5A . UEG B 2 .   ? 150.409 138.800 152.944 1.00 47.37  ? 501 UEG B C5A 1 
HETATM 2819 C C5  . UEG B 2 .   ? 151.055 138.903 151.537 1.00 47.37  ? 501 UEG B C5  1 
HETATM 2820 C C6  . UEG B 2 .   ? 151.842 139.944 151.238 1.00 47.37  ? 501 UEG B C6  1 
HETATM 2821 N N1  . UEG B 2 .   ? 152.413 140.035 150.008 1.00 47.37  ? 501 UEG B N1  1 
HETATM 2822 C C2  . UEG B 2 .   ? 152.225 139.142 149.114 1.00 47.37  ? 501 UEG B C2  1 
HETATM 2823 C C3  . UEG B 2 .   ? 151.419 138.030 149.352 1.00 47.37  ? 501 UEG B C3  1 
HETATM 2824 C C4  . UEG B 2 .   ? 150.828 137.906 150.585 1.00 47.37  ? 501 UEG B C4  1 
HETATM 2825 C C4A . UEG B 2 .   ? 149.923 136.688 150.916 1.00 47.37  ? 501 UEG B C4A 1 
HETATM 2826 O O4A . UEG B 2 .   ? 150.667 135.785 151.707 1.00 47.37  ? 501 UEG B O4A 1 
HETATM 2827 O O3  . UEG B 2 .   ? 151.224 137.009 148.297 1.00 47.37  ? 501 UEG B O3  1 
HETATM 2828 C C2A . UEG B 2 .   ? 152.912 139.305 147.722 1.00 47.37  ? 501 UEG B C2A 1 
# 
