data_8Z7Z
# 
_entry.id   8Z7Z 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Z7Z         pdb_00008z7z 10.2210/pdb8z7z/pdb 
WWPDB D_1300047180 ?            ?                   
EMDB  EMD-39833    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-08 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Z7Z 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'SLC19A2-Thiamine inward structure' 
_pdbx_database_related.db_id          EMD-39833 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
4 qqh@fudan.edu.cn Qianhui Qu  ? 'principal investigator/group leader' 0000-0002-5753-2599 
5 gaopu@ibp.ac.cn  Pu      Gao ? 'principal investigator/group leader' 0000-0002-5328-9755 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Li, P.P.'  1 ? 
'Zhu, Z.N.' 2 ? 
'Wang, Y.'  3 ? 
'Gao, P.'   4 ? 
'Qu, Q.H.'  5 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                10924 
_citation.page_last                 10924 
_citation.title                     'Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-55359-8 
_citation.pdbx_database_id_PubMed   39738067 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Li, P.'    1  ?                   
primary 'Zhu, Z.'   2  ?                   
primary 'Wang, Y.'  3  ?                   
primary 'Zhang, X.' 4  0000-0002-6305-1556 
primary 'Yang, C.'  5  ?                   
primary 'Zhu, Y.'   6  ?                   
primary 'Zhou, Z.'  7  ?                   
primary 'Chao, Y.'  8  ?                   
primary 'Long, Y.'  9  ?                   
primary 'Gao, Y.'   10 ?                   
primary 'Liu, S.'   11 ?                   
primary 'Zhang, L.' 12 0000-0002-9795-0314 
primary 'Gao, P.'   13 0000-0002-5328-9755 
primary 'Qu, Q.'    14 0000-0002-5753-2599 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Thiamine transporter 1'                                                               55432.605 1 ? ? ? ? 
2 non-polymer syn '3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM' 265.355   1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'ThTr-1,ThTr1,Solute carrier family 19 member 2,Thiamine carrier 1,TC1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYS
YLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSY
CRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTD
TPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLW
EKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIY
MLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMK
KCRKLEDPQSSSQVTTS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYS
YLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSY
CRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTD
TPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLW
EKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIY
MLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMK
KCRKLEDPQSSSQVTTS
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        '3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM' 
_pdbx_entity_nonpoly.comp_id     VIB 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   VAL n 
1 4   PRO n 
1 5   GLY n 
1 6   PRO n 
1 7   VAL n 
1 8   SER n 
1 9   ARG n 
1 10  ARG n 
1 11  ALA n 
1 12  ALA n 
1 13  ALA n 
1 14  ALA n 
1 15  ALA n 
1 16  ALA n 
1 17  THR n 
1 18  VAL n 
1 19  LEU n 
1 20  LEU n 
1 21  ARG n 
1 22  THR n 
1 23  ALA n 
1 24  ARG n 
1 25  VAL n 
1 26  ARG n 
1 27  ARG n 
1 28  GLU n 
1 29  CYS n 
1 30  TRP n 
1 31  PHE n 
1 32  LEU n 
1 33  PRO n 
1 34  THR n 
1 35  ALA n 
1 36  LEU n 
1 37  LEU n 
1 38  CYS n 
1 39  ALA n 
1 40  TYR n 
1 41  GLY n 
1 42  PHE n 
1 43  PHE n 
1 44  ALA n 
1 45  SER n 
1 46  LEU n 
1 47  ARG n 
1 48  PRO n 
1 49  SER n 
1 50  GLU n 
1 51  PRO n 
1 52  PHE n 
1 53  LEU n 
1 54  THR n 
1 55  PRO n 
1 56  TYR n 
1 57  LEU n 
1 58  LEU n 
1 59  GLY n 
1 60  PRO n 
1 61  ASP n 
1 62  LYS n 
1 63  ASN n 
1 64  LEU n 
1 65  THR n 
1 66  GLU n 
1 67  ARG n 
1 68  GLU n 
1 69  VAL n 
1 70  PHE n 
1 71  ASN n 
1 72  GLU n 
1 73  ILE n 
1 74  TYR n 
1 75  PRO n 
1 76  VAL n 
1 77  TRP n 
1 78  THR n 
1 79  TYR n 
1 80  SER n 
1 81  TYR n 
1 82  LEU n 
1 83  VAL n 
1 84  LEU n 
1 85  LEU n 
1 86  PHE n 
1 87  PRO n 
1 88  VAL n 
1 89  PHE n 
1 90  LEU n 
1 91  ALA n 
1 92  THR n 
1 93  ASP n 
1 94  TYR n 
1 95  LEU n 
1 96  ARG n 
1 97  TYR n 
1 98  LYS n 
1 99  PRO n 
1 100 VAL n 
1 101 VAL n 
1 102 LEU n 
1 103 LEU n 
1 104 GLN n 
1 105 GLY n 
1 106 LEU n 
1 107 SER n 
1 108 LEU n 
1 109 ILE n 
1 110 VAL n 
1 111 THR n 
1 112 TRP n 
1 113 PHE n 
1 114 MET n 
1 115 LEU n 
1 116 LEU n 
1 117 TYR n 
1 118 ALA n 
1 119 GLN n 
1 120 GLY n 
1 121 LEU n 
1 122 LEU n 
1 123 ALA n 
1 124 ILE n 
1 125 GLN n 
1 126 PHE n 
1 127 LEU n 
1 128 GLU n 
1 129 PHE n 
1 130 PHE n 
1 131 TYR n 
1 132 GLY n 
1 133 ILE n 
1 134 ALA n 
1 135 THR n 
1 136 ALA n 
1 137 THR n 
1 138 GLU n 
1 139 ILE n 
1 140 ALA n 
1 141 TYR n 
1 142 TYR n 
1 143 SER n 
1 144 TYR n 
1 145 ILE n 
1 146 TYR n 
1 147 SER n 
1 148 VAL n 
1 149 VAL n 
1 150 ASP n 
1 151 LEU n 
1 152 GLY n 
1 153 MET n 
1 154 TYR n 
1 155 GLN n 
1 156 LYS n 
1 157 VAL n 
1 158 THR n 
1 159 SER n 
1 160 TYR n 
1 161 CYS n 
1 162 ARG n 
1 163 SER n 
1 164 ALA n 
1 165 THR n 
1 166 LEU n 
1 167 VAL n 
1 168 GLY n 
1 169 PHE n 
1 170 THR n 
1 171 VAL n 
1 172 GLY n 
1 173 SER n 
1 174 VAL n 
1 175 LEU n 
1 176 GLY n 
1 177 GLN n 
1 178 ILE n 
1 179 LEU n 
1 180 VAL n 
1 181 SER n 
1 182 VAL n 
1 183 ALA n 
1 184 GLY n 
1 185 TRP n 
1 186 SER n 
1 187 LEU n 
1 188 PHE n 
1 189 SER n 
1 190 LEU n 
1 191 ASN n 
1 192 VAL n 
1 193 ILE n 
1 194 SER n 
1 195 LEU n 
1 196 THR n 
1 197 CYS n 
1 198 VAL n 
1 199 SER n 
1 200 VAL n 
1 201 ALA n 
1 202 PHE n 
1 203 ALA n 
1 204 VAL n 
1 205 ALA n 
1 206 TRP n 
1 207 PHE n 
1 208 LEU n 
1 209 PRO n 
1 210 MET n 
1 211 PRO n 
1 212 GLN n 
1 213 LYS n 
1 214 SER n 
1 215 LEU n 
1 216 PHE n 
1 217 PHE n 
1 218 HIS n 
1 219 HIS n 
1 220 ILE n 
1 221 PRO n 
1 222 SER n 
1 223 THR n 
1 224 CYS n 
1 225 GLN n 
1 226 ARG n 
1 227 VAL n 
1 228 ASN n 
1 229 GLY n 
1 230 ILE n 
1 231 LYS n 
1 232 VAL n 
1 233 GLN n 
1 234 ASN n 
1 235 GLY n 
1 236 GLY n 
1 237 ILE n 
1 238 VAL n 
1 239 THR n 
1 240 ASP n 
1 241 THR n 
1 242 PRO n 
1 243 ALA n 
1 244 SER n 
1 245 ASN n 
1 246 HIS n 
1 247 LEU n 
1 248 PRO n 
1 249 GLY n 
1 250 TRP n 
1 251 GLU n 
1 252 ASP n 
1 253 ILE n 
1 254 GLU n 
1 255 SER n 
1 256 LYS n 
1 257 ILE n 
1 258 PRO n 
1 259 LEU n 
1 260 ASN n 
1 261 MET n 
1 262 GLU n 
1 263 GLU n 
1 264 PRO n 
1 265 PRO n 
1 266 VAL n 
1 267 GLU n 
1 268 GLU n 
1 269 PRO n 
1 270 GLU n 
1 271 PRO n 
1 272 LYS n 
1 273 PRO n 
1 274 ASP n 
1 275 ARG n 
1 276 LEU n 
1 277 LEU n 
1 278 VAL n 
1 279 LEU n 
1 280 LYS n 
1 281 VAL n 
1 282 LEU n 
1 283 TRP n 
1 284 ASN n 
1 285 ASP n 
1 286 PHE n 
1 287 LEU n 
1 288 MET n 
1 289 CYS n 
1 290 TYR n 
1 291 SER n 
1 292 SER n 
1 293 ARG n 
1 294 PRO n 
1 295 LEU n 
1 296 LEU n 
1 297 CYS n 
1 298 TRP n 
1 299 SER n 
1 300 VAL n 
1 301 TRP n 
1 302 TRP n 
1 303 ALA n 
1 304 LEU n 
1 305 SER n 
1 306 THR n 
1 307 CYS n 
1 308 GLY n 
1 309 TYR n 
1 310 PHE n 
1 311 GLN n 
1 312 VAL n 
1 313 VAL n 
1 314 ASN n 
1 315 TYR n 
1 316 THR n 
1 317 GLN n 
1 318 GLY n 
1 319 LEU n 
1 320 TRP n 
1 321 GLU n 
1 322 LYS n 
1 323 VAL n 
1 324 MET n 
1 325 PRO n 
1 326 SER n 
1 327 ARG n 
1 328 TYR n 
1 329 ALA n 
1 330 ALA n 
1 331 ILE n 
1 332 TYR n 
1 333 ASN n 
1 334 GLY n 
1 335 GLY n 
1 336 VAL n 
1 337 GLU n 
1 338 ALA n 
1 339 VAL n 
1 340 SER n 
1 341 THR n 
1 342 LEU n 
1 343 LEU n 
1 344 GLY n 
1 345 ALA n 
1 346 VAL n 
1 347 ALA n 
1 348 VAL n 
1 349 PHE n 
1 350 ALA n 
1 351 VAL n 
1 352 GLY n 
1 353 TYR n 
1 354 ILE n 
1 355 LYS n 
1 356 ILE n 
1 357 SER n 
1 358 TRP n 
1 359 SER n 
1 360 THR n 
1 361 TRP n 
1 362 GLY n 
1 363 GLU n 
1 364 MET n 
1 365 THR n 
1 366 LEU n 
1 367 SER n 
1 368 LEU n 
1 369 PHE n 
1 370 SER n 
1 371 LEU n 
1 372 LEU n 
1 373 ILE n 
1 374 ALA n 
1 375 ALA n 
1 376 ALA n 
1 377 VAL n 
1 378 TYR n 
1 379 ILE n 
1 380 MET n 
1 381 ASP n 
1 382 THR n 
1 383 VAL n 
1 384 GLY n 
1 385 ASN n 
1 386 ILE n 
1 387 TRP n 
1 388 VAL n 
1 389 CYS n 
1 390 TYR n 
1 391 ALA n 
1 392 SER n 
1 393 TYR n 
1 394 VAL n 
1 395 VAL n 
1 396 PHE n 
1 397 ARG n 
1 398 ILE n 
1 399 ILE n 
1 400 TYR n 
1 401 MET n 
1 402 LEU n 
1 403 LEU n 
1 404 ILE n 
1 405 THR n 
1 406 ILE n 
1 407 ALA n 
1 408 THR n 
1 409 PHE n 
1 410 GLN n 
1 411 ILE n 
1 412 ALA n 
1 413 ALA n 
1 414 ASN n 
1 415 LEU n 
1 416 SER n 
1 417 MET n 
1 418 GLU n 
1 419 ARG n 
1 420 TYR n 
1 421 ALA n 
1 422 LEU n 
1 423 VAL n 
1 424 PHE n 
1 425 GLY n 
1 426 VAL n 
1 427 ASN n 
1 428 THR n 
1 429 PHE n 
1 430 ILE n 
1 431 ALA n 
1 432 LEU n 
1 433 ALA n 
1 434 LEU n 
1 435 GLN n 
1 436 THR n 
1 437 LEU n 
1 438 LEU n 
1 439 THR n 
1 440 LEU n 
1 441 ILE n 
1 442 VAL n 
1 443 VAL n 
1 444 ASP n 
1 445 ALA n 
1 446 SER n 
1 447 GLY n 
1 448 LEU n 
1 449 GLY n 
1 450 LEU n 
1 451 GLU n 
1 452 ILE n 
1 453 THR n 
1 454 THR n 
1 455 GLN n 
1 456 PHE n 
1 457 LEU n 
1 458 ILE n 
1 459 TYR n 
1 460 ALA n 
1 461 SER n 
1 462 TYR n 
1 463 PHE n 
1 464 ALA n 
1 465 LEU n 
1 466 ILE n 
1 467 ALA n 
1 468 VAL n 
1 469 VAL n 
1 470 PHE n 
1 471 LEU n 
1 472 ALA n 
1 473 SER n 
1 474 GLY n 
1 475 ALA n 
1 476 VAL n 
1 477 SER n 
1 478 VAL n 
1 479 MET n 
1 480 LYS n 
1 481 LYS n 
1 482 CYS n 
1 483 ARG n 
1 484 LYS n 
1 485 LEU n 
1 486 GLU n 
1 487 ASP n 
1 488 PRO n 
1 489 GLN n 
1 490 SER n 
1 491 SER n 
1 492 SER n 
1 493 GLN n 
1 494 VAL n 
1 495 THR n 
1 496 THR n 
1 497 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   497 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC19A2, THT1, TRMA' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                ? 'C3 H7 N O2' 
89.093  
ARG 'L-peptide linking' y ARGININE                                                                               ? 
'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                             ? 'C4 H8 N2 O3' 
132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                        ? 'C4 H7 N O4' 
133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                               ? 'C3 H7 N O2 S' 
121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                              ? 'C5 H10 N2 O3' 
146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                        ? 'C5 H9 N O4' 
147.129 
GLY 'peptide linking'   y GLYCINE                                                                                ? 'C2 H5 N O2' 
75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                              ? 
'C6 H10 N3 O2 1'   156.162 
ILE 'L-peptide linking' y ISOLEUCINE                                                                             ? 'C6 H13 N O2' 
131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                ? 'C6 H13 N O2' 
131.173 
LYS 'L-peptide linking' y LYSINE                                                                                 ? 
'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking' y METHIONINE                                                                             ? 'C5 H11 N O2 S' 
149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                          ? 'C9 H11 N O2' 
165.189 
PRO 'L-peptide linking' y PROLINE                                                                                ? 'C5 H9 N O2' 
115.130 
SER 'L-peptide linking' y SERINE                                                                                 ? 'C3 H7 N O3' 
105.093 
THR 'L-peptide linking' y THREONINE                                                                              ? 'C4 H9 N O3' 
119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                             ? 'C11 H12 N2 O2' 
204.225 
TYR 'L-peptide linking' y TYROSINE                                                                               ? 'C9 H11 N O3' 
181.189 
VAL 'L-peptide linking' y VALINE                                                                                 ? 'C5 H11 N O2' 
117.146 
VIB non-polymer         . '3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM' 
'THIAMIN; VITAMIN B1' 'C12 H17 N4 O S 1' 265.355 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASP 2   2   ?   ?   ?   A . n 
A 1 3   VAL 3   3   ?   ?   ?   A . n 
A 1 4   PRO 4   4   ?   ?   ?   A . n 
A 1 5   GLY 5   5   ?   ?   ?   A . n 
A 1 6   PRO 6   6   ?   ?   ?   A . n 
A 1 7   VAL 7   7   ?   ?   ?   A . n 
A 1 8   SER 8   8   ?   ?   ?   A . n 
A 1 9   ARG 9   9   ?   ?   ?   A . n 
A 1 10  ARG 10  10  ?   ?   ?   A . n 
A 1 11  ALA 11  11  ?   ?   ?   A . n 
A 1 12  ALA 12  12  ?   ?   ?   A . n 
A 1 13  ALA 13  13  ?   ?   ?   A . n 
A 1 14  ALA 14  14  ?   ?   ?   A . n 
A 1 15  ALA 15  15  ?   ?   ?   A . n 
A 1 16  ALA 16  16  ?   ?   ?   A . n 
A 1 17  THR 17  17  ?   ?   ?   A . n 
A 1 18  VAL 18  18  ?   ?   ?   A . n 
A 1 19  LEU 19  19  ?   ?   ?   A . n 
A 1 20  LEU 20  20  ?   ?   ?   A . n 
A 1 21  ARG 21  21  ?   ?   ?   A . n 
A 1 22  THR 22  22  ?   ?   ?   A . n 
A 1 23  ALA 23  23  ?   ?   ?   A . n 
A 1 24  ARG 24  24  ?   ?   ?   A . n 
A 1 25  VAL 25  25  ?   ?   ?   A . n 
A 1 26  ARG 26  26  ?   ?   ?   A . n 
A 1 27  ARG 27  27  ?   ?   ?   A . n 
A 1 28  GLU 28  28  ?   ?   ?   A . n 
A 1 29  CYS 29  29  ?   ?   ?   A . n 
A 1 30  TRP 30  30  ?   ?   ?   A . n 
A 1 31  PHE 31  31  31  PHE PHE A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  PRO 33  33  33  PRO PRO A . n 
A 1 34  THR 34  34  34  THR THR A . n 
A 1 35  ALA 35  35  35  ALA ALA A . n 
A 1 36  LEU 36  36  36  LEU LEU A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  ALA 39  39  39  ALA ALA A . n 
A 1 40  TYR 40  40  40  TYR TYR A . n 
A 1 41  GLY 41  41  41  GLY GLY A . n 
A 1 42  PHE 42  42  42  PHE PHE A . n 
A 1 43  PHE 43  43  43  PHE PHE A . n 
A 1 44  ALA 44  44  44  ALA ALA A . n 
A 1 45  SER 45  45  45  SER SER A . n 
A 1 46  LEU 46  46  46  LEU LEU A . n 
A 1 47  ARG 47  47  47  ARG ARG A . n 
A 1 48  PRO 48  48  48  PRO PRO A . n 
A 1 49  SER 49  49  49  SER SER A . n 
A 1 50  GLU 50  50  50  GLU GLU A . n 
A 1 51  PRO 51  51  51  PRO PRO A . n 
A 1 52  PHE 52  52  52  PHE PHE A . n 
A 1 53  LEU 53  53  53  LEU LEU A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  PRO 55  55  55  PRO PRO A . n 
A 1 56  TYR 56  56  56  TYR TYR A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  GLY 59  59  59  GLY GLY A . n 
A 1 60  PRO 60  60  60  PRO PRO A . n 
A 1 61  ASP 61  61  61  ASP ASP A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  THR 65  65  65  THR THR A . n 
A 1 66  GLU 66  66  66  GLU GLU A . n 
A 1 67  ARG 67  67  67  ARG ARG A . n 
A 1 68  GLU 68  68  68  GLU GLU A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  PHE 70  70  70  PHE PHE A . n 
A 1 71  ASN 71  71  71  ASN ASN A . n 
A 1 72  GLU 72  72  72  GLU GLU A . n 
A 1 73  ILE 73  73  73  ILE ILE A . n 
A 1 74  TYR 74  74  74  TYR TYR A . n 
A 1 75  PRO 75  75  75  PRO PRO A . n 
A 1 76  VAL 76  76  76  VAL VAL A . n 
A 1 77  TRP 77  77  77  TRP TRP A . n 
A 1 78  THR 78  78  78  THR THR A . n 
A 1 79  TYR 79  79  79  TYR TYR A . n 
A 1 80  SER 80  80  80  SER SER A . n 
A 1 81  TYR 81  81  81  TYR TYR A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  VAL 83  83  83  VAL VAL A . n 
A 1 84  LEU 84  84  84  LEU LEU A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  PHE 86  86  86  PHE PHE A . n 
A 1 87  PRO 87  87  87  PRO PRO A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  PHE 89  89  89  PHE PHE A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  ALA 91  91  91  ALA ALA A . n 
A 1 92  THR 92  92  92  THR THR A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  TYR 94  94  94  TYR TYR A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  ARG 96  96  96  ARG ARG A . n 
A 1 97  TYR 97  97  97  TYR TYR A . n 
A 1 98  LYS 98  98  98  LYS LYS A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 VAL 100 100 100 VAL VAL A . n 
A 1 101 VAL 101 101 101 VAL VAL A . n 
A 1 102 LEU 102 102 102 LEU LEU A . n 
A 1 103 LEU 103 103 103 LEU LEU A . n 
A 1 104 GLN 104 104 104 GLN GLN A . n 
A 1 105 GLY 105 105 105 GLY GLY A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 SER 107 107 107 SER SER A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 ILE 109 109 109 ILE ILE A . n 
A 1 110 VAL 110 110 110 VAL VAL A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 TRP 112 112 112 TRP TRP A . n 
A 1 113 PHE 113 113 113 PHE PHE A . n 
A 1 114 MET 114 114 114 MET MET A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 TYR 117 117 117 TYR TYR A . n 
A 1 118 ALA 118 118 118 ALA ALA A . n 
A 1 119 GLN 119 119 119 GLN GLN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 LEU 121 121 121 LEU LEU A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 ALA 123 123 123 ALA ALA A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 GLN 125 125 125 GLN GLN A . n 
A 1 126 PHE 126 126 126 PHE PHE A . n 
A 1 127 LEU 127 127 127 LEU LEU A . n 
A 1 128 GLU 128 128 128 GLU GLU A . n 
A 1 129 PHE 129 129 129 PHE PHE A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 TYR 131 131 131 TYR TYR A . n 
A 1 132 GLY 132 132 132 GLY GLY A . n 
A 1 133 ILE 133 133 133 ILE ILE A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ALA 136 136 136 ALA ALA A . n 
A 1 137 THR 137 137 137 THR THR A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 ILE 139 139 139 ILE ILE A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 TYR 141 141 141 TYR TYR A . n 
A 1 142 TYR 142 142 142 TYR TYR A . n 
A 1 143 SER 143 143 143 SER SER A . n 
A 1 144 TYR 144 144 144 TYR TYR A . n 
A 1 145 ILE 145 145 145 ILE ILE A . n 
A 1 146 TYR 146 146 146 TYR TYR A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 VAL 149 149 149 VAL VAL A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 GLY 152 152 152 GLY GLY A . n 
A 1 153 MET 153 153 153 MET MET A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 GLN 155 155 155 GLN GLN A . n 
A 1 156 LYS 156 156 156 LYS LYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 THR 158 158 158 THR THR A . n 
A 1 159 SER 159 159 159 SER SER A . n 
A 1 160 TYR 160 160 160 TYR TYR A . n 
A 1 161 CYS 161 161 161 CYS CYS A . n 
A 1 162 ARG 162 162 162 ARG ARG A . n 
A 1 163 SER 163 163 163 SER SER A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 THR 165 165 165 THR THR A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 VAL 167 167 167 VAL VAL A . n 
A 1 168 GLY 168 168 168 GLY GLY A . n 
A 1 169 PHE 169 169 169 PHE PHE A . n 
A 1 170 THR 170 170 170 THR THR A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 GLY 172 172 172 GLY GLY A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 VAL 174 174 174 VAL VAL A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 GLY 176 176 176 GLY GLY A . n 
A 1 177 GLN 177 177 177 GLN GLN A . n 
A 1 178 ILE 178 178 178 ILE ILE A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 VAL 180 180 180 VAL VAL A . n 
A 1 181 SER 181 181 181 SER SER A . n 
A 1 182 VAL 182 182 182 VAL VAL A . n 
A 1 183 ALA 183 183 183 ALA ALA A . n 
A 1 184 GLY 184 184 184 GLY GLY A . n 
A 1 185 TRP 185 185 185 TRP TRP A . n 
A 1 186 SER 186 186 186 SER SER A . n 
A 1 187 LEU 187 187 187 LEU LEU A . n 
A 1 188 PHE 188 188 188 PHE PHE A . n 
A 1 189 SER 189 189 189 SER SER A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 ASN 191 191 191 ASN ASN A . n 
A 1 192 VAL 192 192 192 VAL VAL A . n 
A 1 193 ILE 193 193 193 ILE ILE A . n 
A 1 194 SER 194 194 194 SER SER A . n 
A 1 195 LEU 195 195 195 LEU LEU A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 CYS 197 197 197 CYS CYS A . n 
A 1 198 VAL 198 198 198 VAL VAL A . n 
A 1 199 SER 199 199 199 SER SER A . n 
A 1 200 VAL 200 200 200 VAL VAL A . n 
A 1 201 ALA 201 201 201 ALA ALA A . n 
A 1 202 PHE 202 202 202 PHE PHE A . n 
A 1 203 ALA 203 203 203 ALA ALA A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 TRP 206 206 206 TRP TRP A . n 
A 1 207 PHE 207 207 207 PHE PHE A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 PRO 209 209 209 PRO PRO A . n 
A 1 210 MET 210 210 210 MET MET A . n 
A 1 211 PRO 211 211 211 PRO PRO A . n 
A 1 212 GLN 212 212 212 GLN GLN A . n 
A 1 213 LYS 213 213 213 LYS LYS A . n 
A 1 214 SER 214 214 ?   ?   ?   A . n 
A 1 215 LEU 215 215 ?   ?   ?   A . n 
A 1 216 PHE 216 216 ?   ?   ?   A . n 
A 1 217 PHE 217 217 ?   ?   ?   A . n 
A 1 218 HIS 218 218 ?   ?   ?   A . n 
A 1 219 HIS 219 219 ?   ?   ?   A . n 
A 1 220 ILE 220 220 ?   ?   ?   A . n 
A 1 221 PRO 221 221 ?   ?   ?   A . n 
A 1 222 SER 222 222 ?   ?   ?   A . n 
A 1 223 THR 223 223 ?   ?   ?   A . n 
A 1 224 CYS 224 224 ?   ?   ?   A . n 
A 1 225 GLN 225 225 ?   ?   ?   A . n 
A 1 226 ARG 226 226 ?   ?   ?   A . n 
A 1 227 VAL 227 227 ?   ?   ?   A . n 
A 1 228 ASN 228 228 ?   ?   ?   A . n 
A 1 229 GLY 229 229 ?   ?   ?   A . n 
A 1 230 ILE 230 230 ?   ?   ?   A . n 
A 1 231 LYS 231 231 ?   ?   ?   A . n 
A 1 232 VAL 232 232 ?   ?   ?   A . n 
A 1 233 GLN 233 233 ?   ?   ?   A . n 
A 1 234 ASN 234 234 ?   ?   ?   A . n 
A 1 235 GLY 235 235 ?   ?   ?   A . n 
A 1 236 GLY 236 236 ?   ?   ?   A . n 
A 1 237 ILE 237 237 ?   ?   ?   A . n 
A 1 238 VAL 238 238 ?   ?   ?   A . n 
A 1 239 THR 239 239 ?   ?   ?   A . n 
A 1 240 ASP 240 240 ?   ?   ?   A . n 
A 1 241 THR 241 241 ?   ?   ?   A . n 
A 1 242 PRO 242 242 ?   ?   ?   A . n 
A 1 243 ALA 243 243 ?   ?   ?   A . n 
A 1 244 SER 244 244 ?   ?   ?   A . n 
A 1 245 ASN 245 245 ?   ?   ?   A . n 
A 1 246 HIS 246 246 ?   ?   ?   A . n 
A 1 247 LEU 247 247 ?   ?   ?   A . n 
A 1 248 PRO 248 248 ?   ?   ?   A . n 
A 1 249 GLY 249 249 ?   ?   ?   A . n 
A 1 250 TRP 250 250 ?   ?   ?   A . n 
A 1 251 GLU 251 251 ?   ?   ?   A . n 
A 1 252 ASP 252 252 ?   ?   ?   A . n 
A 1 253 ILE 253 253 ?   ?   ?   A . n 
A 1 254 GLU 254 254 ?   ?   ?   A . n 
A 1 255 SER 255 255 ?   ?   ?   A . n 
A 1 256 LYS 256 256 ?   ?   ?   A . n 
A 1 257 ILE 257 257 ?   ?   ?   A . n 
A 1 258 PRO 258 258 ?   ?   ?   A . n 
A 1 259 LEU 259 259 ?   ?   ?   A . n 
A 1 260 ASN 260 260 ?   ?   ?   A . n 
A 1 261 MET 261 261 ?   ?   ?   A . n 
A 1 262 GLU 262 262 ?   ?   ?   A . n 
A 1 263 GLU 263 263 ?   ?   ?   A . n 
A 1 264 PRO 264 264 ?   ?   ?   A . n 
A 1 265 PRO 265 265 ?   ?   ?   A . n 
A 1 266 VAL 266 266 ?   ?   ?   A . n 
A 1 267 GLU 267 267 ?   ?   ?   A . n 
A 1 268 GLU 268 268 ?   ?   ?   A . n 
A 1 269 PRO 269 269 ?   ?   ?   A . n 
A 1 270 GLU 270 270 ?   ?   ?   A . n 
A 1 271 PRO 271 271 ?   ?   ?   A . n 
A 1 272 LYS 272 272 ?   ?   ?   A . n 
A 1 273 PRO 273 273 ?   ?   ?   A . n 
A 1 274 ASP 274 274 ?   ?   ?   A . n 
A 1 275 ARG 275 275 ?   ?   ?   A . n 
A 1 276 LEU 276 276 ?   ?   ?   A . n 
A 1 277 LEU 277 277 ?   ?   ?   A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 LEU 279 279 279 LEU LEU A . n 
A 1 280 LYS 280 280 280 LYS LYS A . n 
A 1 281 VAL 281 281 281 VAL VAL A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 TRP 283 283 283 TRP TRP A . n 
A 1 284 ASN 284 284 284 ASN ASN A . n 
A 1 285 ASP 285 285 285 ASP ASP A . n 
A 1 286 PHE 286 286 286 PHE PHE A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 MET 288 288 288 MET MET A . n 
A 1 289 CYS 289 289 289 CYS CYS A . n 
A 1 290 TYR 290 290 290 TYR TYR A . n 
A 1 291 SER 291 291 291 SER SER A . n 
A 1 292 SER 292 292 292 SER SER A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 PRO 294 294 294 PRO PRO A . n 
A 1 295 LEU 295 295 295 LEU LEU A . n 
A 1 296 LEU 296 296 296 LEU LEU A . n 
A 1 297 CYS 297 297 297 CYS CYS A . n 
A 1 298 TRP 298 298 298 TRP TRP A . n 
A 1 299 SER 299 299 299 SER SER A . n 
A 1 300 VAL 300 300 300 VAL VAL A . n 
A 1 301 TRP 301 301 301 TRP TRP A . n 
A 1 302 TRP 302 302 302 TRP TRP A . n 
A 1 303 ALA 303 303 303 ALA ALA A . n 
A 1 304 LEU 304 304 304 LEU LEU A . n 
A 1 305 SER 305 305 305 SER SER A . n 
A 1 306 THR 306 306 306 THR THR A . n 
A 1 307 CYS 307 307 307 CYS CYS A . n 
A 1 308 GLY 308 308 308 GLY GLY A . n 
A 1 309 TYR 309 309 309 TYR TYR A . n 
A 1 310 PHE 310 310 310 PHE PHE A . n 
A 1 311 GLN 311 311 311 GLN GLN A . n 
A 1 312 VAL 312 312 312 VAL VAL A . n 
A 1 313 VAL 313 313 313 VAL VAL A . n 
A 1 314 ASN 314 314 314 ASN ASN A . n 
A 1 315 TYR 315 315 315 TYR TYR A . n 
A 1 316 THR 316 316 316 THR THR A . n 
A 1 317 GLN 317 317 317 GLN GLN A . n 
A 1 318 GLY 318 318 318 GLY GLY A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 TRP 320 320 320 TRP TRP A . n 
A 1 321 GLU 321 321 321 GLU GLU A . n 
A 1 322 LYS 322 322 322 LYS LYS A . n 
A 1 323 VAL 323 323 323 VAL VAL A . n 
A 1 324 MET 324 324 324 MET MET A . n 
A 1 325 PRO 325 325 325 PRO PRO A . n 
A 1 326 SER 326 326 326 SER SER A . n 
A 1 327 ARG 327 327 327 ARG ARG A . n 
A 1 328 TYR 328 328 328 TYR TYR A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 ALA 330 330 330 ALA ALA A . n 
A 1 331 ILE 331 331 331 ILE ILE A . n 
A 1 332 TYR 332 332 332 TYR TYR A . n 
A 1 333 ASN 333 333 333 ASN ASN A . n 
A 1 334 GLY 334 334 334 GLY GLY A . n 
A 1 335 GLY 335 335 335 GLY GLY A . n 
A 1 336 VAL 336 336 336 VAL VAL A . n 
A 1 337 GLU 337 337 337 GLU GLU A . n 
A 1 338 ALA 338 338 338 ALA ALA A . n 
A 1 339 VAL 339 339 339 VAL VAL A . n 
A 1 340 SER 340 340 340 SER SER A . n 
A 1 341 THR 341 341 341 THR THR A . n 
A 1 342 LEU 342 342 342 LEU LEU A . n 
A 1 343 LEU 343 343 343 LEU LEU A . n 
A 1 344 GLY 344 344 344 GLY GLY A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 VAL 346 346 346 VAL VAL A . n 
A 1 347 ALA 347 347 347 ALA ALA A . n 
A 1 348 VAL 348 348 348 VAL VAL A . n 
A 1 349 PHE 349 349 349 PHE PHE A . n 
A 1 350 ALA 350 350 350 ALA ALA A . n 
A 1 351 VAL 351 351 351 VAL VAL A . n 
A 1 352 GLY 352 352 352 GLY GLY A . n 
A 1 353 TYR 353 353 353 TYR TYR A . n 
A 1 354 ILE 354 354 354 ILE ILE A . n 
A 1 355 LYS 355 355 355 LYS LYS A . n 
A 1 356 ILE 356 356 356 ILE ILE A . n 
A 1 357 SER 357 357 357 SER SER A . n 
A 1 358 TRP 358 358 358 TRP TRP A . n 
A 1 359 SER 359 359 359 SER SER A . n 
A 1 360 THR 360 360 360 THR THR A . n 
A 1 361 TRP 361 361 361 TRP TRP A . n 
A 1 362 GLY 362 362 362 GLY GLY A . n 
A 1 363 GLU 363 363 363 GLU GLU A . n 
A 1 364 MET 364 364 364 MET MET A . n 
A 1 365 THR 365 365 365 THR THR A . n 
A 1 366 LEU 366 366 366 LEU LEU A . n 
A 1 367 SER 367 367 367 SER SER A . n 
A 1 368 LEU 368 368 368 LEU LEU A . n 
A 1 369 PHE 369 369 369 PHE PHE A . n 
A 1 370 SER 370 370 370 SER SER A . n 
A 1 371 LEU 371 371 371 LEU LEU A . n 
A 1 372 LEU 372 372 372 LEU LEU A . n 
A 1 373 ILE 373 373 373 ILE ILE A . n 
A 1 374 ALA 374 374 374 ALA ALA A . n 
A 1 375 ALA 375 375 375 ALA ALA A . n 
A 1 376 ALA 376 376 376 ALA ALA A . n 
A 1 377 VAL 377 377 377 VAL VAL A . n 
A 1 378 TYR 378 378 378 TYR TYR A . n 
A 1 379 ILE 379 379 379 ILE ILE A . n 
A 1 380 MET 380 380 380 MET MET A . n 
A 1 381 ASP 381 381 381 ASP ASP A . n 
A 1 382 THR 382 382 382 THR THR A . n 
A 1 383 VAL 383 383 383 VAL VAL A . n 
A 1 384 GLY 384 384 384 GLY GLY A . n 
A 1 385 ASN 385 385 385 ASN ASN A . n 
A 1 386 ILE 386 386 386 ILE ILE A . n 
A 1 387 TRP 387 387 387 TRP TRP A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 CYS 389 389 389 CYS CYS A . n 
A 1 390 TYR 390 390 390 TYR TYR A . n 
A 1 391 ALA 391 391 391 ALA ALA A . n 
A 1 392 SER 392 392 392 SER SER A . n 
A 1 393 TYR 393 393 393 TYR TYR A . n 
A 1 394 VAL 394 394 394 VAL VAL A . n 
A 1 395 VAL 395 395 395 VAL VAL A . n 
A 1 396 PHE 396 396 396 PHE PHE A . n 
A 1 397 ARG 397 397 397 ARG ARG A . n 
A 1 398 ILE 398 398 398 ILE ILE A . n 
A 1 399 ILE 399 399 399 ILE ILE A . n 
A 1 400 TYR 400 400 400 TYR TYR A . n 
A 1 401 MET 401 401 401 MET MET A . n 
A 1 402 LEU 402 402 402 LEU LEU A . n 
A 1 403 LEU 403 403 403 LEU LEU A . n 
A 1 404 ILE 404 404 404 ILE ILE A . n 
A 1 405 THR 405 405 405 THR THR A . n 
A 1 406 ILE 406 406 406 ILE ILE A . n 
A 1 407 ALA 407 407 407 ALA ALA A . n 
A 1 408 THR 408 408 408 THR THR A . n 
A 1 409 PHE 409 409 409 PHE PHE A . n 
A 1 410 GLN 410 410 410 GLN GLN A . n 
A 1 411 ILE 411 411 411 ILE ILE A . n 
A 1 412 ALA 412 412 412 ALA ALA A . n 
A 1 413 ALA 413 413 413 ALA ALA A . n 
A 1 414 ASN 414 414 414 ASN ASN A . n 
A 1 415 LEU 415 415 415 LEU LEU A . n 
A 1 416 SER 416 416 416 SER SER A . n 
A 1 417 MET 417 417 417 MET MET A . n 
A 1 418 GLU 418 418 418 GLU GLU A . n 
A 1 419 ARG 419 419 419 ARG ARG A . n 
A 1 420 TYR 420 420 420 TYR TYR A . n 
A 1 421 ALA 421 421 421 ALA ALA A . n 
A 1 422 LEU 422 422 422 LEU LEU A . n 
A 1 423 VAL 423 423 423 VAL VAL A . n 
A 1 424 PHE 424 424 424 PHE PHE A . n 
A 1 425 GLY 425 425 425 GLY GLY A . n 
A 1 426 VAL 426 426 426 VAL VAL A . n 
A 1 427 ASN 427 427 427 ASN ASN A . n 
A 1 428 THR 428 428 428 THR THR A . n 
A 1 429 PHE 429 429 429 PHE PHE A . n 
A 1 430 ILE 430 430 430 ILE ILE A . n 
A 1 431 ALA 431 431 431 ALA ALA A . n 
A 1 432 LEU 432 432 432 LEU LEU A . n 
A 1 433 ALA 433 433 433 ALA ALA A . n 
A 1 434 LEU 434 434 434 LEU LEU A . n 
A 1 435 GLN 435 435 435 GLN GLN A . n 
A 1 436 THR 436 436 436 THR THR A . n 
A 1 437 LEU 437 437 437 LEU LEU A . n 
A 1 438 LEU 438 438 438 LEU LEU A . n 
A 1 439 THR 439 439 439 THR THR A . n 
A 1 440 LEU 440 440 440 LEU LEU A . n 
A 1 441 ILE 441 441 441 ILE ILE A . n 
A 1 442 VAL 442 442 442 VAL VAL A . n 
A 1 443 VAL 443 443 443 VAL VAL A . n 
A 1 444 ASP 444 444 444 ASP ASP A . n 
A 1 445 ALA 445 445 445 ALA ALA A . n 
A 1 446 SER 446 446 446 SER SER A . n 
A 1 447 GLY 447 447 447 GLY GLY A . n 
A 1 448 LEU 448 448 448 LEU LEU A . n 
A 1 449 GLY 449 449 449 GLY GLY A . n 
A 1 450 LEU 450 450 450 LEU LEU A . n 
A 1 451 GLU 451 451 451 GLU GLU A . n 
A 1 452 ILE 452 452 452 ILE ILE A . n 
A 1 453 THR 453 453 453 THR THR A . n 
A 1 454 THR 454 454 454 THR THR A . n 
A 1 455 GLN 455 455 455 GLN GLN A . n 
A 1 456 PHE 456 456 456 PHE PHE A . n 
A 1 457 LEU 457 457 457 LEU LEU A . n 
A 1 458 ILE 458 458 458 ILE ILE A . n 
A 1 459 TYR 459 459 459 TYR TYR A . n 
A 1 460 ALA 460 460 460 ALA ALA A . n 
A 1 461 SER 461 461 461 SER SER A . n 
A 1 462 TYR 462 462 462 TYR TYR A . n 
A 1 463 PHE 463 463 463 PHE PHE A . n 
A 1 464 ALA 464 464 464 ALA ALA A . n 
A 1 465 LEU 465 465 465 LEU LEU A . n 
A 1 466 ILE 466 466 466 ILE ILE A . n 
A 1 467 ALA 467 467 467 ALA ALA A . n 
A 1 468 VAL 468 468 468 VAL VAL A . n 
A 1 469 VAL 469 469 469 VAL VAL A . n 
A 1 470 PHE 470 470 470 PHE PHE A . n 
A 1 471 LEU 471 471 471 LEU LEU A . n 
A 1 472 ALA 472 472 472 ALA ALA A . n 
A 1 473 SER 473 473 473 SER SER A . n 
A 1 474 GLY 474 474 474 GLY GLY A . n 
A 1 475 ALA 475 475 475 ALA ALA A . n 
A 1 476 VAL 476 476 476 VAL VAL A . n 
A 1 477 SER 477 477 477 SER SER A . n 
A 1 478 VAL 478 478 478 VAL VAL A . n 
A 1 479 MET 479 479 479 MET MET A . n 
A 1 480 LYS 480 480 480 LYS LYS A . n 
A 1 481 LYS 481 481 481 LYS LYS A . n 
A 1 482 CYS 482 482 482 CYS CYS A . n 
A 1 483 ARG 483 483 483 ARG ARG A . n 
A 1 484 LYS 484 484 ?   ?   ?   A . n 
A 1 485 LEU 485 485 ?   ?   ?   A . n 
A 1 486 GLU 486 486 ?   ?   ?   A . n 
A 1 487 ASP 487 487 ?   ?   ?   A . n 
A 1 488 PRO 488 488 ?   ?   ?   A . n 
A 1 489 GLN 489 489 ?   ?   ?   A . n 
A 1 490 SER 490 490 ?   ?   ?   A . n 
A 1 491 SER 491 491 ?   ?   ?   A . n 
A 1 492 SER 492 492 ?   ?   ?   A . n 
A 1 493 GLN 493 493 ?   ?   ?   A . n 
A 1 494 VAL 494 494 ?   ?   ?   A . n 
A 1 495 THR 495 495 ?   ?   ?   A . n 
A 1 496 THR 496 496 ?   ?   ?   A . n 
A 1 497 SER 497 497 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        VIB 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   VIB 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          VIB 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     501 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      VIB 
_pdbx_nonpoly_scheme.auth_mon_id     THM 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A PHE 31  ? CG  ? A PHE 31  CG  
2   1 Y 1 A PHE 31  ? CD1 ? A PHE 31  CD1 
3   1 Y 1 A PHE 31  ? CD2 ? A PHE 31  CD2 
4   1 Y 1 A PHE 31  ? CE1 ? A PHE 31  CE1 
5   1 Y 1 A PHE 31  ? CE2 ? A PHE 31  CE2 
6   1 Y 1 A PHE 31  ? CZ  ? A PHE 31  CZ  
7   1 Y 1 A TYR 117 ? CG  ? A TYR 117 CG  
8   1 Y 1 A TYR 117 ? CD1 ? A TYR 117 CD1 
9   1 Y 1 A TYR 117 ? CD2 ? A TYR 117 CD2 
10  1 Y 1 A TYR 117 ? CE1 ? A TYR 117 CE1 
11  1 Y 1 A TYR 117 ? CE2 ? A TYR 117 CE2 
12  1 Y 1 A TYR 117 ? CZ  ? A TYR 117 CZ  
13  1 Y 1 A TYR 117 ? OH  ? A TYR 117 OH  
14  1 Y 1 A ASP 150 ? CG  ? A ASP 150 CG  
15  1 Y 1 A ASP 150 ? OD1 ? A ASP 150 OD1 
16  1 Y 1 A ASP 150 ? OD2 ? A ASP 150 OD2 
17  1 Y 1 A LEU 151 ? CG  ? A LEU 151 CG  
18  1 Y 1 A LEU 151 ? CD1 ? A LEU 151 CD1 
19  1 Y 1 A LEU 151 ? CD2 ? A LEU 151 CD2 
20  1 Y 1 A MET 153 ? CG  ? A MET 153 CG  
21  1 Y 1 A MET 153 ? SD  ? A MET 153 SD  
22  1 Y 1 A MET 153 ? CE  ? A MET 153 CE  
23  1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
24  1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
25  1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
26  1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
27  1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
28  1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
29  1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
30  1 Y 1 A GLN 155 ? CG  ? A GLN 155 CG  
31  1 Y 1 A GLN 155 ? CD  ? A GLN 155 CD  
32  1 Y 1 A GLN 155 ? OE1 ? A GLN 155 OE1 
33  1 Y 1 A GLN 155 ? NE2 ? A GLN 155 NE2 
34  1 Y 1 A TYR 160 ? CG  ? A TYR 160 CG  
35  1 Y 1 A TYR 160 ? CD1 ? A TYR 160 CD1 
36  1 Y 1 A TYR 160 ? CD2 ? A TYR 160 CD2 
37  1 Y 1 A TYR 160 ? CE1 ? A TYR 160 CE1 
38  1 Y 1 A TYR 160 ? CE2 ? A TYR 160 CE2 
39  1 Y 1 A TYR 160 ? CZ  ? A TYR 160 CZ  
40  1 Y 1 A TYR 160 ? OH  ? A TYR 160 OH  
41  1 Y 1 A GLN 177 ? CG  ? A GLN 177 CG  
42  1 Y 1 A GLN 177 ? CD  ? A GLN 177 CD  
43  1 Y 1 A GLN 177 ? OE1 ? A GLN 177 OE1 
44  1 Y 1 A GLN 177 ? NE2 ? A GLN 177 NE2 
45  1 Y 1 A ILE 178 ? CG1 ? A ILE 178 CG1 
46  1 Y 1 A ILE 178 ? CG2 ? A ILE 178 CG2 
47  1 Y 1 A ILE 178 ? CD1 ? A ILE 178 CD1 
48  1 Y 1 A LEU 179 ? CG  ? A LEU 179 CG  
49  1 Y 1 A LEU 179 ? CD1 ? A LEU 179 CD1 
50  1 Y 1 A LEU 179 ? CD2 ? A LEU 179 CD2 
51  1 Y 1 A VAL 180 ? CG1 ? A VAL 180 CG1 
52  1 Y 1 A VAL 180 ? CG2 ? A VAL 180 CG2 
53  1 Y 1 A SER 181 ? OG  ? A SER 181 OG  
54  1 Y 1 A VAL 182 ? CG1 ? A VAL 182 CG1 
55  1 Y 1 A VAL 182 ? CG2 ? A VAL 182 CG2 
56  1 Y 1 A TRP 185 ? CG  ? A TRP 185 CG  
57  1 Y 1 A TRP 185 ? CD1 ? A TRP 185 CD1 
58  1 Y 1 A TRP 185 ? CD2 ? A TRP 185 CD2 
59  1 Y 1 A TRP 185 ? NE1 ? A TRP 185 NE1 
60  1 Y 1 A TRP 185 ? CE2 ? A TRP 185 CE2 
61  1 Y 1 A TRP 185 ? CE3 ? A TRP 185 CE3 
62  1 Y 1 A TRP 185 ? CZ2 ? A TRP 185 CZ2 
63  1 Y 1 A TRP 185 ? CZ3 ? A TRP 185 CZ3 
64  1 Y 1 A TRP 185 ? CH2 ? A TRP 185 CH2 
65  1 Y 1 A SER 186 ? OG  ? A SER 186 OG  
66  1 Y 1 A LYS 213 ? CG  ? A LYS 213 CG  
67  1 Y 1 A LYS 213 ? CD  ? A LYS 213 CD  
68  1 Y 1 A LYS 213 ? CE  ? A LYS 213 CE  
69  1 Y 1 A LYS 213 ? NZ  ? A LYS 213 NZ  
70  1 Y 1 A VAL 278 ? CG1 ? A VAL 278 CG1 
71  1 Y 1 A VAL 278 ? CG2 ? A VAL 278 CG2 
72  1 Y 1 A LEU 279 ? CG  ? A LEU 279 CG  
73  1 Y 1 A LEU 279 ? CD1 ? A LEU 279 CD1 
74  1 Y 1 A LEU 279 ? CD2 ? A LEU 279 CD2 
75  1 Y 1 A LYS 280 ? CG  ? A LYS 280 CG  
76  1 Y 1 A LYS 280 ? CD  ? A LYS 280 CD  
77  1 Y 1 A LYS 280 ? CE  ? A LYS 280 CE  
78  1 Y 1 A LYS 280 ? NZ  ? A LYS 280 NZ  
79  1 Y 1 A VAL 281 ? CG1 ? A VAL 281 CG1 
80  1 Y 1 A VAL 281 ? CG2 ? A VAL 281 CG2 
81  1 Y 1 A LEU 282 ? CG  ? A LEU 282 CG  
82  1 Y 1 A LEU 282 ? CD1 ? A LEU 282 CD1 
83  1 Y 1 A LEU 282 ? CD2 ? A LEU 282 CD2 
84  1 Y 1 A TRP 283 ? CG  ? A TRP 283 CG  
85  1 Y 1 A TRP 283 ? CD1 ? A TRP 283 CD1 
86  1 Y 1 A TRP 283 ? CD2 ? A TRP 283 CD2 
87  1 Y 1 A TRP 283 ? NE1 ? A TRP 283 NE1 
88  1 Y 1 A TRP 283 ? CE2 ? A TRP 283 CE2 
89  1 Y 1 A TRP 283 ? CE3 ? A TRP 283 CE3 
90  1 Y 1 A TRP 283 ? CZ2 ? A TRP 283 CZ2 
91  1 Y 1 A TRP 283 ? CZ3 ? A TRP 283 CZ3 
92  1 Y 1 A TRP 283 ? CH2 ? A TRP 283 CH2 
93  1 Y 1 A ASN 284 ? CG  ? A ASN 284 CG  
94  1 Y 1 A ASN 284 ? OD1 ? A ASN 284 OD1 
95  1 Y 1 A ASN 284 ? ND2 ? A ASN 284 ND2 
96  1 Y 1 A ASP 285 ? CG  ? A ASP 285 CG  
97  1 Y 1 A ASP 285 ? OD1 ? A ASP 285 OD1 
98  1 Y 1 A ASP 285 ? OD2 ? A ASP 285 OD2 
99  1 Y 1 A PHE 286 ? CG  ? A PHE 286 CG  
100 1 Y 1 A PHE 286 ? CD1 ? A PHE 286 CD1 
101 1 Y 1 A PHE 286 ? CD2 ? A PHE 286 CD2 
102 1 Y 1 A PHE 286 ? CE1 ? A PHE 286 CE1 
103 1 Y 1 A PHE 286 ? CE2 ? A PHE 286 CE2 
104 1 Y 1 A PHE 286 ? CZ  ? A PHE 286 CZ  
105 1 Y 1 A LEU 287 ? CG  ? A LEU 287 CG  
106 1 Y 1 A LEU 287 ? CD1 ? A LEU 287 CD1 
107 1 Y 1 A LEU 287 ? CD2 ? A LEU 287 CD2 
108 1 Y 1 A MET 288 ? CG  ? A MET 288 CG  
109 1 Y 1 A MET 288 ? SD  ? A MET 288 SD  
110 1 Y 1 A MET 288 ? CE  ? A MET 288 CE  
111 1 Y 1 A CYS 289 ? SG  ? A CYS 289 SG  
112 1 Y 1 A TYR 290 ? CG  ? A TYR 290 CG  
113 1 Y 1 A TYR 290 ? CD1 ? A TYR 290 CD1 
114 1 Y 1 A TYR 290 ? CD2 ? A TYR 290 CD2 
115 1 Y 1 A TYR 290 ? CE1 ? A TYR 290 CE1 
116 1 Y 1 A TYR 290 ? CE2 ? A TYR 290 CE2 
117 1 Y 1 A TYR 290 ? CZ  ? A TYR 290 CZ  
118 1 Y 1 A TYR 290 ? OH  ? A TYR 290 OH  
119 1 Y 1 A SER 291 ? OG  ? A SER 291 OG  
120 1 Y 1 A SER 292 ? OG  ? A SER 292 OG  
121 1 Y 1 A ARG 293 ? CG  ? A ARG 293 CG  
122 1 Y 1 A ARG 293 ? CD  ? A ARG 293 CD  
123 1 Y 1 A ARG 293 ? NE  ? A ARG 293 NE  
124 1 Y 1 A ARG 293 ? CZ  ? A ARG 293 CZ  
125 1 Y 1 A ARG 293 ? NH1 ? A ARG 293 NH1 
126 1 Y 1 A ARG 293 ? NH2 ? A ARG 293 NH2 
127 1 Y 1 A PRO 294 ? CG  ? A PRO 294 CG  
128 1 Y 1 A PRO 294 ? CD  ? A PRO 294 CD  
129 1 Y 1 A LEU 295 ? CG  ? A LEU 295 CG  
130 1 Y 1 A LEU 295 ? CD1 ? A LEU 295 CD1 
131 1 Y 1 A LEU 295 ? CD2 ? A LEU 295 CD2 
132 1 Y 1 A MET 324 ? CG  ? A MET 324 CG  
133 1 Y 1 A MET 324 ? SD  ? A MET 324 SD  
134 1 Y 1 A MET 324 ? CE  ? A MET 324 CE  
135 1 Y 1 A ARG 327 ? CG  ? A ARG 327 CG  
136 1 Y 1 A ARG 327 ? CD  ? A ARG 327 CD  
137 1 Y 1 A ARG 327 ? NE  ? A ARG 327 NE  
138 1 Y 1 A ARG 327 ? CZ  ? A ARG 327 CZ  
139 1 Y 1 A ARG 327 ? NH1 ? A ARG 327 NH1 
140 1 Y 1 A ARG 327 ? NH2 ? A ARG 327 NH2 
141 1 Y 1 A TYR 328 ? CG  ? A TYR 328 CG  
142 1 Y 1 A TYR 328 ? CD1 ? A TYR 328 CD1 
143 1 Y 1 A TYR 328 ? CD2 ? A TYR 328 CD2 
144 1 Y 1 A TYR 328 ? CE1 ? A TYR 328 CE1 
145 1 Y 1 A TYR 328 ? CE2 ? A TYR 328 CE2 
146 1 Y 1 A TYR 328 ? CZ  ? A TYR 328 CZ  
147 1 Y 1 A TYR 328 ? OH  ? A TYR 328 OH  
148 1 Y 1 A VAL 348 ? CG1 ? A VAL 348 CG1 
149 1 Y 1 A VAL 348 ? CG2 ? A VAL 348 CG2 
150 1 Y 1 A PHE 349 ? CG  ? A PHE 349 CG  
151 1 Y 1 A PHE 349 ? CD1 ? A PHE 349 CD1 
152 1 Y 1 A PHE 349 ? CD2 ? A PHE 349 CD2 
153 1 Y 1 A PHE 349 ? CE1 ? A PHE 349 CE1 
154 1 Y 1 A PHE 349 ? CE2 ? A PHE 349 CE2 
155 1 Y 1 A PHE 349 ? CZ  ? A PHE 349 CZ  
156 1 Y 1 A VAL 351 ? CG1 ? A VAL 351 CG1 
157 1 Y 1 A VAL 351 ? CG2 ? A VAL 351 CG2 
158 1 Y 1 A TYR 353 ? CG  ? A TYR 353 CG  
159 1 Y 1 A TYR 353 ? CD1 ? A TYR 353 CD1 
160 1 Y 1 A TYR 353 ? CD2 ? A TYR 353 CD2 
161 1 Y 1 A TYR 353 ? CE1 ? A TYR 353 CE1 
162 1 Y 1 A TYR 353 ? CE2 ? A TYR 353 CE2 
163 1 Y 1 A TYR 353 ? CZ  ? A TYR 353 CZ  
164 1 Y 1 A TYR 353 ? OH  ? A TYR 353 OH  
165 1 Y 1 A ILE 354 ? CG1 ? A ILE 354 CG1 
166 1 Y 1 A ILE 354 ? CG2 ? A ILE 354 CG2 
167 1 Y 1 A ILE 354 ? CD1 ? A ILE 354 CD1 
168 1 Y 1 A LYS 355 ? CG  ? A LYS 355 CG  
169 1 Y 1 A LYS 355 ? CD  ? A LYS 355 CD  
170 1 Y 1 A LYS 355 ? CE  ? A LYS 355 CE  
171 1 Y 1 A LYS 355 ? NZ  ? A LYS 355 NZ  
172 1 Y 1 A ILE 356 ? CG1 ? A ILE 356 CG1 
173 1 Y 1 A ILE 356 ? CG2 ? A ILE 356 CG2 
174 1 Y 1 A ILE 356 ? CD1 ? A ILE 356 CD1 
175 1 Y 1 A SER 357 ? OG  ? A SER 357 OG  
176 1 Y 1 A TRP 358 ? CG  ? A TRP 358 CG  
177 1 Y 1 A TRP 358 ? CD1 ? A TRP 358 CD1 
178 1 Y 1 A TRP 358 ? CD2 ? A TRP 358 CD2 
179 1 Y 1 A TRP 358 ? NE1 ? A TRP 358 NE1 
180 1 Y 1 A TRP 358 ? CE2 ? A TRP 358 CE2 
181 1 Y 1 A TRP 358 ? CE3 ? A TRP 358 CE3 
182 1 Y 1 A TRP 358 ? CZ2 ? A TRP 358 CZ2 
183 1 Y 1 A TRP 358 ? CZ3 ? A TRP 358 CZ3 
184 1 Y 1 A TRP 358 ? CH2 ? A TRP 358 CH2 
185 1 Y 1 A SER 359 ? OG  ? A SER 359 OG  
186 1 Y 1 A THR 360 ? OG1 ? A THR 360 OG1 
187 1 Y 1 A THR 360 ? CG2 ? A THR 360 CG2 
188 1 Y 1 A TRP 361 ? CG  ? A TRP 361 CG  
189 1 Y 1 A TRP 361 ? CD1 ? A TRP 361 CD1 
190 1 Y 1 A TRP 361 ? CD2 ? A TRP 361 CD2 
191 1 Y 1 A TRP 361 ? NE1 ? A TRP 361 NE1 
192 1 Y 1 A TRP 361 ? CE2 ? A TRP 361 CE2 
193 1 Y 1 A TRP 361 ? CE3 ? A TRP 361 CE3 
194 1 Y 1 A TRP 361 ? CZ2 ? A TRP 361 CZ2 
195 1 Y 1 A TRP 361 ? CZ3 ? A TRP 361 CZ3 
196 1 Y 1 A TRP 361 ? CH2 ? A TRP 361 CH2 
197 1 Y 1 A GLU 363 ? CG  ? A GLU 363 CG  
198 1 Y 1 A GLU 363 ? CD  ? A GLU 363 CD  
199 1 Y 1 A GLU 363 ? OE1 ? A GLU 363 OE1 
200 1 Y 1 A GLU 363 ? OE2 ? A GLU 363 OE2 
201 1 Y 1 A PHE 369 ? CG  ? A PHE 369 CG  
202 1 Y 1 A PHE 369 ? CD1 ? A PHE 369 CD1 
203 1 Y 1 A PHE 369 ? CD2 ? A PHE 369 CD2 
204 1 Y 1 A PHE 369 ? CE1 ? A PHE 369 CE1 
205 1 Y 1 A PHE 369 ? CE2 ? A PHE 369 CE2 
206 1 Y 1 A PHE 369 ? CZ  ? A PHE 369 CZ  
207 1 Y 1 A ASN 414 ? CG  ? A ASN 414 CG  
208 1 Y 1 A ASN 414 ? OD1 ? A ASN 414 OD1 
209 1 Y 1 A ASN 414 ? ND2 ? A ASN 414 ND2 
210 1 Y 1 A LEU 415 ? CG  ? A LEU 415 CG  
211 1 Y 1 A LEU 415 ? CD1 ? A LEU 415 CD1 
212 1 Y 1 A LEU 415 ? CD2 ? A LEU 415 CD2 
213 1 Y 1 A SER 416 ? OG  ? A SER 416 OG  
214 1 Y 1 A MET 417 ? CG  ? A MET 417 CG  
215 1 Y 1 A MET 417 ? SD  ? A MET 417 SD  
216 1 Y 1 A MET 417 ? CE  ? A MET 417 CE  
217 1 Y 1 A GLU 418 ? CG  ? A GLU 418 CG  
218 1 Y 1 A GLU 418 ? CD  ? A GLU 418 CD  
219 1 Y 1 A GLU 418 ? OE1 ? A GLU 418 OE1 
220 1 Y 1 A GLU 418 ? OE2 ? A GLU 418 OE2 
221 1 Y 1 A ARG 419 ? CG  ? A ARG 419 CG  
222 1 Y 1 A ARG 419 ? CD  ? A ARG 419 CD  
223 1 Y 1 A ARG 419 ? NE  ? A ARG 419 NE  
224 1 Y 1 A ARG 419 ? CZ  ? A ARG 419 CZ  
225 1 Y 1 A ARG 419 ? NH1 ? A ARG 419 NH1 
226 1 Y 1 A ARG 419 ? NH2 ? A ARG 419 NH2 
227 1 Y 1 A PHE 424 ? CG  ? A PHE 424 CG  
228 1 Y 1 A PHE 424 ? CD1 ? A PHE 424 CD1 
229 1 Y 1 A PHE 424 ? CD2 ? A PHE 424 CD2 
230 1 Y 1 A PHE 424 ? CE1 ? A PHE 424 CE1 
231 1 Y 1 A PHE 424 ? CE2 ? A PHE 424 CE2 
232 1 Y 1 A PHE 424 ? CZ  ? A PHE 424 CZ  
233 1 Y 1 A PHE 470 ? CG  ? A PHE 470 CG  
234 1 Y 1 A PHE 470 ? CD1 ? A PHE 470 CD1 
235 1 Y 1 A PHE 470 ? CD2 ? A PHE 470 CD2 
236 1 Y 1 A PHE 470 ? CE1 ? A PHE 470 CE1 
237 1 Y 1 A PHE 470 ? CE2 ? A PHE 470 CE2 
238 1 Y 1 A PHE 470 ? CZ  ? A PHE 470 CZ  
239 1 Y 1 A VAL 476 ? CG1 ? A VAL 476 CG1 
240 1 Y 1 A VAL 476 ? CG2 ? A VAL 476 CG2 
241 1 Y 1 A SER 477 ? OG  ? A SER 477 OG  
242 1 Y 1 A VAL 478 ? CG1 ? A VAL 478 CG1 
243 1 Y 1 A VAL 478 ? CG2 ? A VAL 478 CG2 
244 1 Y 1 A MET 479 ? CG  ? A MET 479 CG  
245 1 Y 1 A MET 479 ? SD  ? A MET 479 SD  
246 1 Y 1 A MET 479 ? CE  ? A MET 479 CE  
247 1 Y 1 A LYS 480 ? CG  ? A LYS 480 CG  
248 1 Y 1 A LYS 480 ? CD  ? A LYS 480 CD  
249 1 Y 1 A LYS 480 ? CE  ? A LYS 480 CE  
250 1 Y 1 A LYS 480 ? NZ  ? A LYS 480 NZ  
251 1 Y 1 A LYS 481 ? CG  ? A LYS 481 CG  
252 1 Y 1 A LYS 481 ? CD  ? A LYS 481 CD  
253 1 Y 1 A LYS 481 ? CE  ? A LYS 481 CE  
254 1 Y 1 A LYS 481 ? NZ  ? A LYS 481 NZ  
255 1 Y 1 A CYS 482 ? SG  ? A CYS 482 SG  
256 1 Y 1 A ARG 483 ? CG  ? A ARG 483 CG  
257 1 Y 1 A ARG 483 ? CD  ? A ARG 483 CD  
258 1 Y 1 A ARG 483 ? NE  ? A ARG 483 NE  
259 1 Y 1 A ARG 483 ? CZ  ? A ARG 483 CZ  
260 1 Y 1 A ARG 483 ? NH1 ? A ARG 483 NH1 
261 1 Y 1 A ARG 483 ? NH2 ? A ARG 483 NH2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Z7Z 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Z7Z 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Z7Z 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 8Z7Z 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 2902 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.650 ? 3993 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 5.870 ? 418  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.044 ? 497  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 484  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     8Z7Z 
_struct.title                        'SLC19A2-Thiamine inward structure' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Z7Z 
_struct_keywords.text            'Thiamine transporter, MFS, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    S19A2_HUMAN 
_struct_ref.pdbx_db_accession          O60779 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYS
YLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSY
CRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTD
TPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLW
EKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIY
MLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMK
KCRKLEDPQSSSQVTTS
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8Z7Z 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 497 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O60779 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  497 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       497 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PHE A 31  ? LEU A 46  ? PHE A 31  LEU A 46  1 ? 16 
HELX_P HELX_P2  AA2 LEU A 53  ? LEU A 58  ? LEU A 53  LEU A 58  1 ? 6  
HELX_P HELX_P3  AA3 THR A 65  ? LEU A 95  ? THR A 65  LEU A 95  1 ? 31 
HELX_P HELX_P4  AA4 LYS A 98  ? TYR A 117 ? LYS A 98  TYR A 117 1 ? 20 
HELX_P HELX_P5  AA5 LEU A 121 ? ALA A 136 ? LEU A 121 ALA A 136 1 ? 16 
HELX_P HELX_P6  AA6 THR A 137 ? ILE A 145 ? THR A 137 ILE A 145 1 ? 9  
HELX_P HELX_P7  AA7 TYR A 146 ? VAL A 148 ? TYR A 146 VAL A 148 5 ? 3  
HELX_P HELX_P8  AA8 MET A 153 ? VAL A 182 ? MET A 153 VAL A 182 1 ? 30 
HELX_P HELX_P9  AA9 SER A 186 ? TRP A 206 ? SER A 186 TRP A 206 1 ? 21 
HELX_P HELX_P10 AB1 LEU A 279 ? CYS A 289 ? LEU A 279 CYS A 289 1 ? 11 
HELX_P HELX_P11 AB2 SER A 292 ? CYS A 297 ? SER A 292 CYS A 297 1 ? 6  
HELX_P HELX_P12 AB3 TRP A 298 ? MET A 324 ? TRP A 298 MET A 324 1 ? 27 
HELX_P HELX_P13 AB4 TYR A 332 ? GLY A 352 ? TYR A 332 GLY A 352 1 ? 21 
HELX_P HELX_P14 AB5 SER A 357 ? VAL A 383 ? SER A 357 VAL A 383 1 ? 27 
HELX_P HELX_P15 AB6 ASN A 385 ? LEU A 415 ? ASN A 385 LEU A 415 1 ? 31 
HELX_P HELX_P16 AB7 SER A 416 ? GLU A 418 ? SER A 416 GLU A 418 5 ? 3  
HELX_P HELX_P17 AB8 ARG A 419 ? VAL A 443 ? ARG A 419 VAL A 443 1 ? 25 
HELX_P HELX_P18 AB9 GLU A 451 ? ARG A 483 ? GLU A 451 ARG A 483 1 ? 33 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   8Z7Z 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O  A LEU 304 ? ? OH A TYR 462 ? ? 2.17 
2 1 OG A SER 173 ? ? O  A GLY 334 ? ? 2.18 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 97  ? ? 70.36   -9.15 
2 1 SER A 291 ? ? -91.00  51.50 
3 1 TRP A 298 ? ? 70.86   -9.56 
4 1 TYR A 332 ? ? -101.32 65.27 
5 1 TRP A 361 ? ? -144.77 31.68 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8Z7Z 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8Z7Z 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.23 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               247315 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            6.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'SLC19A3-Thiamine complex' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8Z7Z 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              8Z7Z 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8Z7Z 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ASP 2   ? A ASP 2   
3   1 Y 1 A VAL 3   ? A VAL 3   
4   1 Y 1 A PRO 4   ? A PRO 4   
5   1 Y 1 A GLY 5   ? A GLY 5   
6   1 Y 1 A PRO 6   ? A PRO 6   
7   1 Y 1 A VAL 7   ? A VAL 7   
8   1 Y 1 A SER 8   ? A SER 8   
9   1 Y 1 A ARG 9   ? A ARG 9   
10  1 Y 1 A ARG 10  ? A ARG 10  
11  1 Y 1 A ALA 11  ? A ALA 11  
12  1 Y 1 A ALA 12  ? A ALA 12  
13  1 Y 1 A ALA 13  ? A ALA 13  
14  1 Y 1 A ALA 14  ? A ALA 14  
15  1 Y 1 A ALA 15  ? A ALA 15  
16  1 Y 1 A ALA 16  ? A ALA 16  
17  1 Y 1 A THR 17  ? A THR 17  
18  1 Y 1 A VAL 18  ? A VAL 18  
19  1 Y 1 A LEU 19  ? A LEU 19  
20  1 Y 1 A LEU 20  ? A LEU 20  
21  1 Y 1 A ARG 21  ? A ARG 21  
22  1 Y 1 A THR 22  ? A THR 22  
23  1 Y 1 A ALA 23  ? A ALA 23  
24  1 Y 1 A ARG 24  ? A ARG 24  
25  1 Y 1 A VAL 25  ? A VAL 25  
26  1 Y 1 A ARG 26  ? A ARG 26  
27  1 Y 1 A ARG 27  ? A ARG 27  
28  1 Y 1 A GLU 28  ? A GLU 28  
29  1 Y 1 A CYS 29  ? A CYS 29  
30  1 Y 1 A TRP 30  ? A TRP 30  
31  1 Y 1 A SER 214 ? A SER 214 
32  1 Y 1 A LEU 215 ? A LEU 215 
33  1 Y 1 A PHE 216 ? A PHE 216 
34  1 Y 1 A PHE 217 ? A PHE 217 
35  1 Y 1 A HIS 218 ? A HIS 218 
36  1 Y 1 A HIS 219 ? A HIS 219 
37  1 Y 1 A ILE 220 ? A ILE 220 
38  1 Y 1 A PRO 221 ? A PRO 221 
39  1 Y 1 A SER 222 ? A SER 222 
40  1 Y 1 A THR 223 ? A THR 223 
41  1 Y 1 A CYS 224 ? A CYS 224 
42  1 Y 1 A GLN 225 ? A GLN 225 
43  1 Y 1 A ARG 226 ? A ARG 226 
44  1 Y 1 A VAL 227 ? A VAL 227 
45  1 Y 1 A ASN 228 ? A ASN 228 
46  1 Y 1 A GLY 229 ? A GLY 229 
47  1 Y 1 A ILE 230 ? A ILE 230 
48  1 Y 1 A LYS 231 ? A LYS 231 
49  1 Y 1 A VAL 232 ? A VAL 232 
50  1 Y 1 A GLN 233 ? A GLN 233 
51  1 Y 1 A ASN 234 ? A ASN 234 
52  1 Y 1 A GLY 235 ? A GLY 235 
53  1 Y 1 A GLY 236 ? A GLY 236 
54  1 Y 1 A ILE 237 ? A ILE 237 
55  1 Y 1 A VAL 238 ? A VAL 238 
56  1 Y 1 A THR 239 ? A THR 239 
57  1 Y 1 A ASP 240 ? A ASP 240 
58  1 Y 1 A THR 241 ? A THR 241 
59  1 Y 1 A PRO 242 ? A PRO 242 
60  1 Y 1 A ALA 243 ? A ALA 243 
61  1 Y 1 A SER 244 ? A SER 244 
62  1 Y 1 A ASN 245 ? A ASN 245 
63  1 Y 1 A HIS 246 ? A HIS 246 
64  1 Y 1 A LEU 247 ? A LEU 247 
65  1 Y 1 A PRO 248 ? A PRO 248 
66  1 Y 1 A GLY 249 ? A GLY 249 
67  1 Y 1 A TRP 250 ? A TRP 250 
68  1 Y 1 A GLU 251 ? A GLU 251 
69  1 Y 1 A ASP 252 ? A ASP 252 
70  1 Y 1 A ILE 253 ? A ILE 253 
71  1 Y 1 A GLU 254 ? A GLU 254 
72  1 Y 1 A SER 255 ? A SER 255 
73  1 Y 1 A LYS 256 ? A LYS 256 
74  1 Y 1 A ILE 257 ? A ILE 257 
75  1 Y 1 A PRO 258 ? A PRO 258 
76  1 Y 1 A LEU 259 ? A LEU 259 
77  1 Y 1 A ASN 260 ? A ASN 260 
78  1 Y 1 A MET 261 ? A MET 261 
79  1 Y 1 A GLU 262 ? A GLU 262 
80  1 Y 1 A GLU 263 ? A GLU 263 
81  1 Y 1 A PRO 264 ? A PRO 264 
82  1 Y 1 A PRO 265 ? A PRO 265 
83  1 Y 1 A VAL 266 ? A VAL 266 
84  1 Y 1 A GLU 267 ? A GLU 267 
85  1 Y 1 A GLU 268 ? A GLU 268 
86  1 Y 1 A PRO 269 ? A PRO 269 
87  1 Y 1 A GLU 270 ? A GLU 270 
88  1 Y 1 A PRO 271 ? A PRO 271 
89  1 Y 1 A LYS 272 ? A LYS 272 
90  1 Y 1 A PRO 273 ? A PRO 273 
91  1 Y 1 A ASP 274 ? A ASP 274 
92  1 Y 1 A ARG 275 ? A ARG 275 
93  1 Y 1 A LEU 276 ? A LEU 276 
94  1 Y 1 A LEU 277 ? A LEU 277 
95  1 Y 1 A LYS 484 ? A LYS 484 
96  1 Y 1 A LEU 485 ? A LEU 485 
97  1 Y 1 A GLU 486 ? A GLU 486 
98  1 Y 1 A ASP 487 ? A ASP 487 
99  1 Y 1 A PRO 488 ? A PRO 488 
100 1 Y 1 A GLN 489 ? A GLN 489 
101 1 Y 1 A SER 490 ? A SER 490 
102 1 Y 1 A SER 491 ? A SER 491 
103 1 Y 1 A SER 492 ? A SER 492 
104 1 Y 1 A GLN 493 ? A GLN 493 
105 1 Y 1 A VAL 494 ? A VAL 494 
106 1 Y 1 A THR 495 ? A THR 495 
107 1 Y 1 A THR 496 ? A THR 496 
108 1 Y 1 A SER 497 ? A SER 497 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
VIB CM2  C N N 388 
VIB N4A  N N N 389 
VIB CM4  C N N 390 
VIB O1   O N N 391 
VIB C7   C N N 392 
VIB C6   C N N 393 
VIB C2   C Y N 394 
VIB S1   S Y N 395 
VIB C5   C Y N 396 
VIB C4   C Y N 397 
VIB N3   N Y N 398 
VIB C7A  C N N 399 
VIB C4A  C Y N 400 
VIB N3A  N Y N 401 
VIB C2A  C Y N 402 
VIB N1A  N Y N 403 
VIB C6A  C Y N 404 
VIB C5A  C Y N 405 
VIB HM21 H N N 406 
VIB HM22 H N N 407 
VIB HM23 H N N 408 
VIB H4A1 H N N 409 
VIB H4A2 H N N 410 
VIB HM41 H N N 411 
VIB HM42 H N N 412 
VIB HM43 H N N 413 
VIB HO1  H N N 414 
VIB HC71 H N N 415 
VIB HC72 H N N 416 
VIB HC61 H N N 417 
VIB HC62 H N N 418 
VIB HC2  H N N 419 
VIB H7A1 H N N 420 
VIB H7A2 H N N 421 
VIB H6AC H N N 422 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
VIB CM2 C2A  sing N N 374 
VIB CM2 HM21 sing N N 375 
VIB CM2 HM22 sing N N 376 
VIB CM2 HM23 sing N N 377 
VIB N4A C4A  sing N N 378 
VIB N4A H4A1 sing N N 379 
VIB N4A H4A2 sing N N 380 
VIB CM4 C4   sing N N 381 
VIB CM4 HM41 sing N N 382 
VIB CM4 HM42 sing N N 383 
VIB CM4 HM43 sing N N 384 
VIB O1  C7   sing N N 385 
VIB O1  HO1  sing N N 386 
VIB C7  C6   sing N N 387 
VIB C7  HC71 sing N N 388 
VIB C7  HC72 sing N N 389 
VIB C6  C5   sing N N 390 
VIB C6  HC61 sing N N 391 
VIB C6  HC62 sing N N 392 
VIB C2  S1   sing Y N 393 
VIB C2  N3   doub Y N 394 
VIB C2  HC2  sing N N 395 
VIB S1  C5   sing Y N 396 
VIB C5  C4   doub Y N 397 
VIB C4  N3   sing Y N 398 
VIB N3  C7A  sing N N 399 
VIB C7A C5A  sing N N 400 
VIB C7A H7A1 sing N N 401 
VIB C7A H7A2 sing N N 402 
VIB C4A N3A  sing Y N 403 
VIB C4A C5A  doub Y N 404 
VIB N3A C2A  doub Y N 405 
VIB C2A N1A  sing Y N 406 
VIB N1A C6A  doub Y N 407 
VIB C6A C5A  sing Y N 408 
VIB C6A H6AC sing N N 409 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-21 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8Z7Z 
_em_admin.last_update        2025-01-08 
_em_admin.map_release_date   2025-01-08 
_em_admin.title              'SLC19A2-Thiamine inward structure' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    8Z7Z 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 31  ? 134.094 144.128 122.310 1.00 53.58  ? 31  PHE A N   1 
ATOM   2    C CA  . PHE A 1 31  ? 134.235 144.004 123.756 1.00 53.58  ? 31  PHE A CA  1 
ATOM   3    C C   . PHE A 1 31  ? 135.665 144.300 124.192 1.00 53.58  ? 31  PHE A C   1 
ATOM   4    O O   . PHE A 1 31  ? 136.130 143.780 125.203 1.00 53.58  ? 31  PHE A O   1 
ATOM   5    C CB  . PHE A 1 31  ? 133.825 142.604 124.218 1.00 53.58  ? 31  PHE A CB  1 
ATOM   6    N N   . LEU A 1 32  ? 136.355 145.132 123.412 1.00 51.71  ? 32  LEU A N   1 
ATOM   7    C CA  . LEU A 1 32  ? 137.758 145.433 123.695 1.00 51.71  ? 32  LEU A CA  1 
ATOM   8    C C   . LEU A 1 32  ? 137.979 146.141 125.029 1.00 51.71  ? 32  LEU A C   1 
ATOM   9    O O   . LEU A 1 32  ? 138.877 145.716 125.778 1.00 51.71  ? 32  LEU A O   1 
ATOM   10   C CB  . LEU A 1 32  ? 138.352 146.238 122.533 1.00 51.71  ? 32  LEU A CB  1 
ATOM   11   C CG  . LEU A 1 32  ? 139.663 146.977 122.809 1.00 51.71  ? 32  LEU A CG  1 
ATOM   12   C CD1 . LEU A 1 32  ? 140.806 145.993 123.028 1.00 51.71  ? 32  LEU A CD1 1 
ATOM   13   C CD2 . LEU A 1 32  ? 139.987 147.943 121.678 1.00 51.71  ? 32  LEU A CD2 1 
ATOM   14   N N   . PRO A 1 33  ? 137.260 147.219 125.379 1.00 51.71  ? 33  PRO A N   1 
ATOM   15   C CA  . PRO A 1 33  ? 137.551 147.886 126.663 1.00 51.71  ? 33  PRO A CA  1 
ATOM   16   C C   . PRO A 1 33  ? 137.341 147.001 127.878 1.00 51.71  ? 33  PRO A C   1 
ATOM   17   O O   . PRO A 1 33  ? 138.098 147.113 128.850 1.00 51.71  ? 33  PRO A O   1 
ATOM   18   C CB  . PRO A 1 33  ? 136.587 149.080 126.665 1.00 51.71  ? 33  PRO A CB  1 
ATOM   19   C CG  . PRO A 1 33  ? 135.504 148.695 125.728 1.00 51.71  ? 33  PRO A CG  1 
ATOM   20   C CD  . PRO A 1 33  ? 136.192 147.927 124.649 1.00 51.71  ? 33  PRO A CD  1 
ATOM   21   N N   . THR A 1 34  ? 136.336 146.128 127.858 1.00 52.60  ? 34  THR A N   1 
ATOM   22   C CA  . THR A 1 34  ? 136.105 145.219 128.973 1.00 52.60  ? 34  THR A CA  1 
ATOM   23   C C   . THR A 1 34  ? 137.077 144.046 128.963 1.00 52.60  ? 34  THR A C   1 
ATOM   24   O O   . THR A 1 34  ? 137.528 143.605 130.027 1.00 52.60  ? 34  THR A O   1 
ATOM   25   C CB  . THR A 1 34  ? 134.662 144.705 128.946 1.00 52.60  ? 34  THR A CB  1 
ATOM   26   O OG1 . THR A 1 34  ? 133.762 145.816 128.858 1.00 52.60  ? 34  THR A OG1 1 
ATOM   27   C CG2 . THR A 1 34  ? 134.349 143.913 130.207 1.00 52.60  ? 34  THR A CG2 1 
ATOM   28   N N   . ALA A 1 35  ? 137.415 143.535 127.776 1.00 49.17  ? 35  ALA A N   1 
ATOM   29   C CA  . ALA A 1 35  ? 138.366 142.434 127.686 1.00 49.17  ? 35  ALA A CA  1 
ATOM   30   C C   . ALA A 1 35  ? 139.747 142.861 128.160 1.00 49.17  ? 35  ALA A C   1 
ATOM   31   O O   . ALA A 1 35  ? 140.443 142.098 128.836 1.00 49.17  ? 35  ALA A O   1 
ATOM   32   C CB  . ALA A 1 35  ? 138.429 141.908 126.253 1.00 49.17  ? 35  ALA A CB  1 
ATOM   33   N N   . LEU A 1 36  ? 140.162 144.082 127.819 1.00 44.32  ? 36  LEU A N   1 
ATOM   34   C CA  . LEU A 1 36  ? 141.458 144.567 128.282 1.00 44.32  ? 36  LEU A CA  1 
ATOM   35   C C   . LEU A 1 36  ? 141.464 144.730 129.798 1.00 44.32  ? 36  LEU A C   1 
ATOM   36   O O   . LEU A 1 36  ? 142.456 144.406 130.463 1.00 44.32  ? 36  LEU A O   1 
ATOM   37   C CB  . LEU A 1 36  ? 141.799 145.882 127.578 1.00 44.32  ? 36  LEU A CB  1 
ATOM   38   C CG  . LEU A 1 36  ? 143.230 146.425 127.645 1.00 44.32  ? 36  LEU A CG  1 
ATOM   39   C CD1 . LEU A 1 36  ? 143.533 147.223 126.390 1.00 44.32  ? 36  LEU A CD1 1 
ATOM   40   C CD2 . LEU A 1 36  ? 143.459 147.280 128.872 1.00 44.32  ? 36  LEU A CD2 1 
ATOM   41   N N   . LEU A 1 37  ? 140.357 145.215 130.365 1.00 43.57  ? 37  LEU A N   1 
ATOM   42   C CA  . LEU A 1 37  ? 140.288 145.393 131.811 1.00 43.57  ? 37  LEU A CA  1 
ATOM   43   C C   . LEU A 1 37  ? 140.319 144.048 132.528 1.00 43.57  ? 37  LEU A C   1 
ATOM   44   O O   . LEU A 1 37  ? 140.986 143.902 133.559 1.00 43.57  ? 37  LEU A O   1 
ATOM   45   C CB  . LEU A 1 37  ? 139.029 146.179 132.181 1.00 43.57  ? 37  LEU A CB  1 
ATOM   46   C CG  . LEU A 1 37  ? 138.968 146.879 133.545 1.00 43.57  ? 37  LEU A CG  1 
ATOM   47   C CD1 . LEU A 1 37  ? 137.997 148.044 133.473 1.00 43.57  ? 37  LEU A CD1 1 
ATOM   48   C CD2 . LEU A 1 37  ? 138.600 145.952 134.686 1.00 43.57  ? 37  LEU A CD2 1 
ATOM   49   N N   . CYS A 1 38  ? 139.607 143.050 131.997 1.00 44.14  ? 38  CYS A N   1 
ATOM   50   C CA  . CYS A 1 38  ? 139.627 141.736 132.631 1.00 44.14  ? 38  CYS A CA  1 
ATOM   51   C C   . CYS A 1 38  ? 140.971 141.047 132.440 1.00 44.14  ? 38  CYS A C   1 
ATOM   52   O O   . CYS A 1 38  ? 141.390 140.274 133.303 1.00 44.14  ? 38  CYS A O   1 
ATOM   53   C CB  . CYS A 1 38  ? 138.496 140.855 132.100 1.00 44.14  ? 38  CYS A CB  1 
ATOM   54   S SG  . CYS A 1 38  ? 138.802 140.083 130.501 1.00 44.14  ? 38  CYS A SG  1 
ATOM   55   N N   . ALA A 1 39  ? 141.668 141.322 131.332 1.00 42.24  ? 39  ALA A N   1 
ATOM   56   C CA  . ALA A 1 39  ? 143.035 140.830 131.176 1.00 42.24  ? 39  ALA A CA  1 
ATOM   57   C C   . ALA A 1 39  ? 143.966 141.461 132.202 1.00 42.24  ? 39  ALA A C   1 
ATOM   58   O O   . ALA A 1 39  ? 144.838 140.783 132.759 1.00 42.24  ? 39  ALA A O   1 
ATOM   59   C CB  . ALA A 1 39  ? 143.536 141.104 129.760 1.00 42.24  ? 39  ALA A CB  1 
ATOM   60   N N   . TYR A 1 40  ? 143.798 142.759 132.463 1.00 39.56  ? 40  TYR A N   1 
ATOM   61   C CA  . TYR A 1 40  ? 144.586 143.403 133.508 1.00 39.56  ? 40  TYR A CA  1 
ATOM   62   C C   . TYR A 1 40  ? 144.289 142.798 134.872 1.00 39.56  ? 40  TYR A C   1 
ATOM   63   O O   . TYR A 1 40  ? 145.205 142.576 135.669 1.00 39.56  ? 40  TYR A O   1 
ATOM   64   C CB  . TYR A 1 40  ? 144.319 144.905 133.541 1.00 39.56  ? 40  TYR A CB  1 
ATOM   65   C CG  . TYR A 1 40  ? 144.760 145.542 134.839 1.00 39.56  ? 40  TYR A CG  1 
ATOM   66   C CD1 . TYR A 1 40  ? 146.104 145.619 135.172 1.00 39.56  ? 40  TYR A CD1 1 
ATOM   67   C CD2 . TYR A 1 40  ? 143.832 146.049 135.738 1.00 39.56  ? 40  TYR A CD2 1 
ATOM   68   C CE1 . TYR A 1 40  ? 146.515 146.190 136.359 1.00 39.56  ? 40  TYR A CE1 1 
ATOM   69   C CE2 . TYR A 1 40  ? 144.234 146.623 136.929 1.00 39.56  ? 40  TYR A CE2 1 
ATOM   70   C CZ  . TYR A 1 40  ? 145.577 146.690 137.233 1.00 39.56  ? 40  TYR A CZ  1 
ATOM   71   O OH  . TYR A 1 40  ? 145.985 147.262 138.413 1.00 39.56  ? 40  TYR A OH  1 
ATOM   72   N N   . GLY A 1 41  ? 143.013 142.552 135.169 1.00 36.34  ? 41  GLY A N   1 
ATOM   73   C CA  . GLY A 1 41  ? 142.670 141.917 136.432 1.00 36.34  ? 41  GLY A CA  1 
ATOM   74   C C   . GLY A 1 41  ? 143.249 140.521 136.549 1.00 36.34  ? 41  GLY A C   1 
ATOM   75   O O   . GLY A 1 41  ? 143.776 140.139 137.597 1.00 36.34  ? 41  GLY A O   1 
ATOM   76   N N   . PHE A 1 42  ? 143.177 139.751 135.461 1.00 34.04  ? 42  PHE A N   1 
ATOM   77   C CA  . PHE A 1 42  ? 143.733 138.405 135.433 1.00 34.04  ? 42  PHE A CA  1 
ATOM   78   C C   . PHE A 1 42  ? 145.235 138.423 135.681 1.00 34.04  ? 42  PHE A C   1 
ATOM   79   O O   . PHE A 1 42  ? 145.758 137.588 136.426 1.00 34.04  ? 42  PHE A O   1 
ATOM   80   C CB  . PHE A 1 42  ? 143.408 137.762 134.082 1.00 34.04  ? 42  PHE A CB  1 
ATOM   81   C CG  . PHE A 1 42  ? 144.024 136.410 133.873 1.00 34.04  ? 42  PHE A CG  1 
ATOM   82   C CD1 . PHE A 1 42  ? 143.371 135.268 134.290 1.00 34.04  ? 42  PHE A CD1 1 
ATOM   83   C CD2 . PHE A 1 42  ? 145.243 136.281 133.232 1.00 34.04  ? 42  PHE A CD2 1 
ATOM   84   C CE1 . PHE A 1 42  ? 143.931 134.024 134.090 1.00 34.04  ? 42  PHE A CE1 1 
ATOM   85   C CE2 . PHE A 1 42  ? 145.808 135.042 133.031 1.00 34.04  ? 42  PHE A CE2 1 
ATOM   86   C CZ  . PHE A 1 42  ? 145.152 133.912 133.459 1.00 34.04  ? 42  PHE A CZ  1 
ATOM   87   N N   . PHE A 1 43  ? 145.946 139.368 135.065 1.00 33.31  ? 43  PHE A N   1 
ATOM   88   C CA  . PHE A 1 43  ? 147.397 139.404 135.204 1.00 33.31  ? 43  PHE A CA  1 
ATOM   89   C C   . PHE A 1 43  ? 147.831 139.966 136.554 1.00 33.31  ? 43  PHE A C   1 
ATOM   90   O O   . PHE A 1 43  ? 148.795 139.472 137.149 1.00 33.31  ? 43  PHE A O   1 
ATOM   91   C CB  . PHE A 1 43  ? 148.007 140.211 134.062 1.00 33.31  ? 43  PHE A CB  1 
ATOM   92   C CG  . PHE A 1 43  ? 148.156 139.431 132.792 1.00 33.31  ? 43  PHE A CG  1 
ATOM   93   C CD1 . PHE A 1 43  ? 148.640 138.135 132.818 1.00 33.31  ? 43  PHE A CD1 1 
ATOM   94   C CD2 . PHE A 1 43  ? 147.805 139.986 131.577 1.00 33.31  ? 43  PHE A CD2 1 
ATOM   95   C CE1 . PHE A 1 43  ? 148.779 137.410 131.654 1.00 33.31  ? 43  PHE A CE1 1 
ATOM   96   C CE2 . PHE A 1 43  ? 147.942 139.266 130.409 1.00 33.31  ? 43  PHE A CE2 1 
ATOM   97   C CZ  . PHE A 1 43  ? 148.429 137.975 130.448 1.00 33.31  ? 43  PHE A CZ  1 
ATOM   98   N N   . ALA A 1 44  ? 147.141 140.995 137.053 1.00 34.30  ? 44  ALA A N   1 
ATOM   99   C CA  . ALA A 1 44  ? 147.484 141.562 138.353 1.00 34.30  ? 44  ALA A CA  1 
ATOM   100  C C   . ALA A 1 44  ? 147.185 140.584 139.476 1.00 34.30  ? 44  ALA A C   1 
ATOM   101  O O   . ALA A 1 44  ? 147.932 140.509 140.458 1.00 34.30  ? 44  ALA A O   1 
ATOM   102  C CB  . ALA A 1 44  ? 146.732 142.874 138.570 1.00 34.30  ? 44  ALA A CB  1 
ATOM   103  N N   . SER A 1 45  ? 146.094 139.830 139.354 1.00 28.87  ? 45  SER A N   1 
ATOM   104  C CA  . SER A 1 45  ? 145.744 138.855 140.371 1.00 28.87  ? 45  SER A CA  1 
ATOM   105  C C   . SER A 1 45  ? 146.530 137.560 140.245 1.00 28.87  ? 45  SER A C   1 
ATOM   106  O O   . SER A 1 45  ? 146.528 136.765 141.189 1.00 28.87  ? 45  SER A O   1 
ATOM   107  C CB  . SER A 1 45  ? 144.247 138.560 140.309 1.00 28.87  ? 45  SER A CB  1 
ATOM   108  O OG  . SER A 1 45  ? 143.505 139.763 140.215 1.00 28.87  ? 45  SER A OG  1 
ATOM   109  N N   . LEU A 1 46  ? 147.207 137.330 139.120 1.00 30.92  ? 46  LEU A N   1 
ATOM   110  C CA  . LEU A 1 46  ? 147.944 136.083 138.914 1.00 30.92  ? 46  LEU A CA  1 
ATOM   111  C C   . LEU A 1 46  ? 149.274 136.201 139.648 1.00 30.92  ? 46  LEU A C   1 
ATOM   112  O O   . LEU A 1 46  ? 150.315 136.537 139.080 1.00 30.92  ? 46  LEU A O   1 
ATOM   113  C CB  . LEU A 1 46  ? 148.138 135.797 137.429 1.00 30.92  ? 46  LEU A CB  1 
ATOM   114  C CG  . LEU A 1 46  ? 148.523 134.373 137.006 1.00 30.92  ? 46  LEU A CG  1 
ATOM   115  C CD1 . LEU A 1 46  ? 148.049 134.109 135.589 1.00 30.92  ? 46  LEU A CD1 1 
ATOM   116  C CD2 . LEU A 1 46  ? 150.011 134.097 137.116 1.00 30.92  ? 46  LEU A CD2 1 
ATOM   117  N N   . ARG A 1 47  ? 149.228 135.925 140.946 1.00 28.15  ? 47  ARG A N   1 
ATOM   118  C CA  . ARG A 1 47  ? 150.430 135.924 141.771 1.00 28.15  ? 47  ARG A CA  1 
ATOM   119  C C   . ARG A 1 47  ? 150.668 134.512 142.279 1.00 28.15  ? 47  ARG A C   1 
ATOM   120  O O   . ARG A 1 47  ? 150.070 134.106 143.288 1.00 28.15  ? 47  ARG A O   1 
ATOM   121  C CB  . ARG A 1 47  ? 150.293 136.904 142.938 1.00 28.15  ? 47  ARG A CB  1 
ATOM   122  C CG  . ARG A 1 47  ? 149.856 138.295 142.521 1.00 28.15  ? 47  ARG A CG  1 
ATOM   123  C CD  . ARG A 1 47  ? 149.223 139.035 143.680 1.00 28.15  ? 47  ARG A CD  1 
ATOM   124  N NE  . ARG A 1 47  ? 148.437 140.181 143.242 1.00 28.15  ? 47  ARG A NE  1 
ATOM   125  C CZ  . ARG A 1 47  ? 147.411 140.682 143.914 1.00 28.15  ? 47  ARG A CZ  1 
ATOM   126  N NH1 . ARG A 1 47  ? 147.018 140.160 145.064 1.00 28.15  ? 47  ARG A NH1 1 
ATOM   127  N NH2 . ARG A 1 47  ? 146.763 141.733 143.421 1.00 28.15  ? 47  ARG A NH2 1 
ATOM   128  N N   . PRO A 1 48  ? 151.520 133.722 141.621 1.00 29.57  ? 48  PRO A N   1 
ATOM   129  C CA  . PRO A 1 48  ? 151.763 132.347 142.073 1.00 29.57  ? 48  PRO A CA  1 
ATOM   130  C C   . PRO A 1 48  ? 152.567 132.241 143.357 1.00 29.57  ? 48  PRO A C   1 
ATOM   131  O O   . PRO A 1 48  ? 152.801 131.121 143.823 1.00 29.57  ? 48  PRO A O   1 
ATOM   132  C CB  . PRO A 1 48  ? 152.534 131.726 140.900 1.00 29.57  ? 48  PRO A CB  1 
ATOM   133  C CG  . PRO A 1 48  ? 153.134 132.870 140.182 1.00 29.57  ? 48  PRO A CG  1 
ATOM   134  C CD  . PRO A 1 48  ? 152.204 134.026 140.354 1.00 29.57  ? 48  PRO A CD  1 
ATOM   135  N N   . SER A 1 49  ? 152.994 133.354 143.952 1.00 32.66  ? 49  SER A N   1 
ATOM   136  C CA  . SER A 1 49  ? 153.868 133.291 145.114 1.00 32.66  ? 49  SER A CA  1 
ATOM   137  C C   . SER A 1 49  ? 153.176 133.619 146.428 1.00 32.66  ? 49  SER A C   1 
ATOM   138  O O   . SER A 1 49  ? 153.751 133.354 147.487 1.00 32.66  ? 49  SER A O   1 
ATOM   139  C CB  . SER A 1 49  ? 155.060 134.231 144.930 1.00 32.66  ? 49  SER A CB  1 
ATOM   140  O OG  . SER A 1 49  ? 155.737 134.440 146.156 1.00 32.66  ? 49  SER A OG  1 
ATOM   141  N N   . GLU A 1 50  ? 151.980 134.201 146.396 1.00 34.21  ? 50  GLU A N   1 
ATOM   142  C CA  . GLU A 1 50  ? 151.211 134.328 147.632 1.00 34.21  ? 50  GLU A CA  1 
ATOM   143  C C   . GLU A 1 50  ? 150.925 132.971 148.266 1.00 34.21  ? 50  GLU A C   1 
ATOM   144  O O   . GLU A 1 50  ? 151.005 132.869 149.502 1.00 34.21  ? 50  GLU A O   1 
ATOM   145  C CB  . GLU A 1 50  ? 149.930 135.130 147.380 1.00 34.21  ? 50  GLU A CB  1 
ATOM   146  C CG  . GLU A 1 50  ? 150.161 136.609 147.152 1.00 34.21  ? 50  GLU A CG  1 
ATOM   147  C CD  . GLU A 1 50  ? 148.870 137.400 147.126 1.00 34.21  ? 50  GLU A CD  1 
ATOM   148  O OE1 . GLU A 1 50  ? 147.806 136.809 147.396 1.00 34.21  ? 50  GLU A OE1 1 
ATOM   149  O OE2 . GLU A 1 50  ? 148.918 138.615 146.846 1.00 34.21  ? 50  GLU A OE2 1 
ATOM   150  N N   . PRO A 1 51  ? 150.561 131.903 147.509 1.00 35.86  ? 51  PRO A N   1 
ATOM   151  C CA  . PRO A 1 51  ? 150.550 130.558 148.104 1.00 35.86  ? 51  PRO A CA  1 
ATOM   152  C C   . PRO A 1 51  ? 151.849 130.195 148.805 1.00 35.86  ? 51  PRO A C   1 
ATOM   153  O O   . PRO A 1 51  ? 151.858 129.904 150.005 1.00 35.86  ? 51  PRO A O   1 
ATOM   154  C CB  . PRO A 1 51  ? 150.318 129.639 146.896 1.00 35.86  ? 51  PRO A CB  1 
ATOM   155  C CG  . PRO A 1 51  ? 149.848 130.510 145.783 1.00 35.86  ? 51  PRO A CG  1 
ATOM   156  C CD  . PRO A 1 51  ? 149.810 131.927 146.242 1.00 35.86  ? 51  PRO A CD  1 
ATOM   157  N N   . PHE A 1 52  ? 152.954 130.208 148.061 1.00 37.76  ? 52  PHE A N   1 
ATOM   158  C CA  . PHE A 1 52  ? 154.257 129.812 148.595 1.00 37.76  ? 52  PHE A CA  1 
ATOM   159  C C   . PHE A 1 52  ? 155.039 131.063 148.994 1.00 37.76  ? 52  PHE A C   1 
ATOM   160  O O   . PHE A 1 52  ? 155.975 131.499 148.321 1.00 37.76  ? 52  PHE A O   1 
ATOM   161  C CB  . PHE A 1 52  ? 155.026 128.985 147.573 1.00 37.76  ? 52  PHE A CB  1 
ATOM   162  C CG  . PHE A 1 52  ? 154.492 127.592 147.374 1.00 37.76  ? 52  PHE A CG  1 
ATOM   163  C CD1 . PHE A 1 52  ? 155.285 126.492 147.647 1.00 37.76  ? 52  PHE A CD1 1 
ATOM   164  C CD2 . PHE A 1 52  ? 153.216 127.382 146.881 1.00 37.76  ? 52  PHE A CD2 1 
ATOM   165  C CE1 . PHE A 1 52  ? 154.809 125.212 147.456 1.00 37.76  ? 52  PHE A CE1 1 
ATOM   166  C CE2 . PHE A 1 52  ? 152.735 126.104 146.689 1.00 37.76  ? 52  PHE A CE2 1 
ATOM   167  C CZ  . PHE A 1 52  ? 153.533 125.018 146.977 1.00 37.76  ? 52  PHE A CZ  1 
ATOM   168  N N   . LEU A 1 53  ? 154.634 131.645 150.123 1.00 34.25  ? 53  LEU A N   1 
ATOM   169  C CA  . LEU A 1 53  ? 155.245 132.873 150.612 1.00 34.25  ? 53  LEU A CA  1 
ATOM   170  C C   . LEU A 1 53  ? 156.063 132.691 151.880 1.00 34.25  ? 53  LEU A C   1 
ATOM   171  O O   . LEU A 1 53  ? 157.254 133.020 151.879 1.00 34.25  ? 53  LEU A O   1 
ATOM   172  C CB  . LEU A 1 53  ? 154.168 133.933 150.875 1.00 34.25  ? 53  LEU A CB  1 
ATOM   173  C CG  . LEU A 1 53  ? 154.696 135.238 151.467 1.00 34.25  ? 53  LEU A CG  1 
ATOM   174  C CD1 . LEU A 1 53  ? 155.659 135.909 150.504 1.00 34.25  ? 53  LEU A CD1 1 
ATOM   175  C CD2 . LEU A 1 53  ? 153.553 136.163 151.828 1.00 34.25  ? 53  LEU A CD2 1 
ATOM   176  N N   . THR A 1 54  ? 155.464 132.187 152.948 1.00 36.74  ? 54  THR A N   1 
ATOM   177  C CA  . THR A 1 54  ? 156.142 131.969 154.219 1.00 36.74  ? 54  THR A CA  1 
ATOM   178  C C   . THR A 1 54  ? 157.317 130.995 154.105 1.00 36.74  ? 54  THR A C   1 
ATOM   179  O O   . THR A 1 54  ? 158.374 131.265 154.692 1.00 36.74  ? 54  THR A O   1 
ATOM   180  C CB  . THR A 1 54  ? 155.132 131.504 155.272 1.00 36.74  ? 54  THR A CB  1 
ATOM   181  O OG1 . THR A 1 54  ? 154.077 132.469 155.371 1.00 36.74  ? 54  THR A OG1 1 
ATOM   182  C CG2 . THR A 1 54  ? 155.792 131.339 156.624 1.00 36.74  ? 54  THR A CG2 1 
ATOM   183  N N   . PRO A 1 55  ? 157.201 129.861 153.396 1.00 36.10  ? 55  PRO A N   1 
ATOM   184  C CA  . PRO A 1 55  ? 158.399 129.025 153.206 1.00 36.10  ? 55  PRO A CA  1 
ATOM   185  C C   . PRO A 1 55  ? 159.533 129.745 152.500 1.00 36.10  ? 55  PRO A C   1 
ATOM   186  O O   . PRO A 1 55  ? 160.703 129.459 152.780 1.00 36.10  ? 55  PRO A O   1 
ATOM   187  C CB  . PRO A 1 55  ? 157.874 127.843 152.381 1.00 36.10  ? 55  PRO A CB  1 
ATOM   188  C CG  . PRO A 1 55  ? 156.443 127.763 152.729 1.00 36.10  ? 55  PRO A CG  1 
ATOM   189  C CD  . PRO A 1 55  ? 156.002 129.185 152.863 1.00 36.10  ? 55  PRO A CD  1 
ATOM   190  N N   . TYR A 1 56  ? 159.226 130.669 151.587 1.00 33.59  ? 56  TYR A N   1 
ATOM   191  C CA  . TYR A 1 56  ? 160.273 131.483 150.979 1.00 33.59  ? 56  TYR A CA  1 
ATOM   192  C C   . TYR A 1 56  ? 160.848 132.479 151.979 1.00 33.59  ? 56  TYR A C   1 
ATOM   193  O O   . TYR A 1 56  ? 162.071 132.633 152.085 1.00 33.59  ? 56  TYR A O   1 
ATOM   194  C CB  . TYR A 1 56  ? 159.728 132.216 149.755 1.00 33.59  ? 56  TYR A CB  1 
ATOM   195  C CG  . TYR A 1 56  ? 160.679 133.253 149.202 1.00 33.59  ? 56  TYR A CG  1 
ATOM   196  C CD1 . TYR A 1 56  ? 161.743 132.888 148.391 1.00 33.59  ? 56  TYR A CD1 1 
ATOM   197  C CD2 . TYR A 1 56  ? 160.516 134.598 149.501 1.00 33.59  ? 56  TYR A CD2 1 
ATOM   198  C CE1 . TYR A 1 56  ? 162.614 133.837 147.889 1.00 33.59  ? 56  TYR A CE1 1 
ATOM   199  C CE2 . TYR A 1 56  ? 161.383 135.548 149.009 1.00 33.59  ? 56  TYR A CE2 1 
ATOM   200  C CZ  . TYR A 1 56  ? 162.427 135.166 148.201 1.00 33.59  ? 56  TYR A CZ  1 
ATOM   201  O OH  . TYR A 1 56  ? 163.288 136.119 147.708 1.00 33.59  ? 56  TYR A OH  1 
ATOM   202  N N   . LEU A 1 57  ? 159.976 133.174 152.714 1.00 30.86  ? 57  LEU A N   1 
ATOM   203  C CA  . LEU A 1 57  ? 160.430 134.235 153.607 1.00 30.86  ? 57  LEU A CA  1 
ATOM   204  C C   . LEU A 1 57  ? 161.290 133.684 154.735 1.00 30.86  ? 57  LEU A C   1 
ATOM   205  O O   . LEU A 1 57  ? 162.268 134.317 155.145 1.00 30.86  ? 57  LEU A O   1 
ATOM   206  C CB  . LEU A 1 57  ? 159.227 134.995 154.163 1.00 30.86  ? 57  LEU A CB  1 
ATOM   207  C CG  . LEU A 1 57  ? 158.864 136.289 153.433 1.00 30.86  ? 57  LEU A CG  1 
ATOM   208  C CD1 . LEU A 1 57  ? 157.512 136.804 153.876 1.00 30.86  ? 57  LEU A CD1 1 
ATOM   209  C CD2 . LEU A 1 57  ? 159.928 137.336 153.670 1.00 30.86  ? 57  LEU A CD2 1 
ATOM   210  N N   . LEU A 1 58  ? 160.943 132.508 155.251 1.00 34.31  ? 58  LEU A N   1 
ATOM   211  C CA  . LEU A 1 58  ? 161.694 131.873 156.326 1.00 34.31  ? 58  LEU A CA  1 
ATOM   212  C C   . LEU A 1 58  ? 162.742 130.888 155.826 1.00 34.31  ? 58  LEU A C   1 
ATOM   213  O O   . LEU A 1 58  ? 163.397 130.235 156.644 1.00 34.31  ? 58  LEU A O   1 
ATOM   214  C CB  . LEU A 1 58  ? 160.741 131.160 157.293 1.00 34.31  ? 58  LEU A CB  1 
ATOM   215  C CG  . LEU A 1 58  ? 159.963 131.997 158.312 1.00 34.31  ? 58  LEU A CG  1 
ATOM   216  C CD1 . LEU A 1 58  ? 158.869 132.826 157.668 1.00 34.31  ? 58  LEU A CD1 1 
ATOM   217  C CD2 . LEU A 1 58  ? 159.380 131.089 159.379 1.00 34.31  ? 58  LEU A CD2 1 
ATOM   218  N N   . GLY A 1 59  ? 162.918 130.763 154.515 1.00 37.22  ? 59  GLY A N   1 
ATOM   219  C CA  . GLY A 1 59  ? 163.870 129.830 153.965 1.00 37.22  ? 59  GLY A CA  1 
ATOM   220  C C   . GLY A 1 59  ? 165.280 130.381 153.955 1.00 37.22  ? 59  GLY A C   1 
ATOM   221  O O   . GLY A 1 59  ? 165.563 131.443 154.519 1.00 37.22  ? 59  GLY A O   1 
ATOM   222  N N   . PRO A 1 60  ? 166.202 129.654 153.318 1.00 40.19  ? 60  PRO A N   1 
ATOM   223  C CA  . PRO A 1 60  ? 167.588 130.145 153.217 1.00 40.19  ? 60  PRO A CA  1 
ATOM   224  C C   . PRO A 1 60  ? 167.724 131.435 152.428 1.00 40.19  ? 60  PRO A C   1 
ATOM   225  O O   . PRO A 1 60  ? 168.765 132.096 152.529 1.00 40.19  ? 60  PRO A O   1 
ATOM   226  C CB  . PRO A 1 60  ? 168.336 128.997 152.522 1.00 40.19  ? 60  PRO A CB  1 
ATOM   227  C CG  . PRO A 1 60  ? 167.413 127.842 152.477 1.00 40.19  ? 60  PRO A CG  1 
ATOM   228  C CD  . PRO A 1 60  ? 166.044 128.254 152.888 1.00 40.19  ? 60  PRO A CD  1 
ATOM   229  N N   . ASP A 1 61  ? 166.714 131.807 151.638 1.00 36.62  ? 61  ASP A N   1 
ATOM   230  C CA  . ASP A 1 61  ? 166.821 132.988 150.787 1.00 36.62  ? 61  ASP A CA  1 
ATOM   231  C C   . ASP A 1 61  ? 166.952 134.268 151.606 1.00 36.62  ? 61  ASP A C   1 
ATOM   232  O O   . ASP A 1 61  ? 167.719 135.166 151.240 1.00 36.62  ? 61  ASP A O   1 
ATOM   233  C CB  . ASP A 1 61  ? 165.613 133.061 149.855 1.00 36.62  ? 61  ASP A CB  1 
ATOM   234  C CG  . ASP A 1 61  ? 165.669 132.021 148.755 1.00 36.62  ? 61  ASP A CG  1 
ATOM   235  O OD1 . ASP A 1 61  ? 166.781 131.732 148.266 1.00 36.62  ? 61  ASP A OD1 1 
ATOM   236  O OD2 . ASP A 1 61  ? 164.606 131.480 148.388 1.00 36.62  ? 61  ASP A OD2 1 
ATOM   237  N N   . LYS A 1 62  ? 166.216 134.375 152.711 1.00 31.53  ? 62  LYS A N   1 
ATOM   238  C CA  . LYS A 1 62  ? 166.270 135.565 153.551 1.00 31.53  ? 62  LYS A CA  1 
ATOM   239  C C   . LYS A 1 62  ? 166.661 135.296 154.996 1.00 31.53  ? 62  LYS A C   1 
ATOM   240  O O   . LYS A 1 62  ? 167.118 136.230 155.667 1.00 31.53  ? 62  LYS A O   1 
ATOM   241  C CB  . LYS A 1 62  ? 164.921 136.297 153.530 1.00 31.53  ? 62  LYS A CB  1 
ATOM   242  C CG  . LYS A 1 62  ? 164.477 136.709 152.137 1.00 31.53  ? 62  LYS A CG  1 
ATOM   243  C CD  . LYS A 1 62  ? 163.287 137.649 152.183 1.00 31.53  ? 62  LYS A CD  1 
ATOM   244  C CE  . LYS A 1 62  ? 163.118 138.383 150.867 1.00 31.53  ? 62  LYS A CE  1 
ATOM   245  N NZ  . LYS A 1 62  ? 163.796 137.673 149.748 1.00 31.53  ? 62  LYS A NZ  1 
ATOM   246  N N   . ASN A 1 63  ? 166.503 134.066 155.495 1.00 36.12  ? 63  ASN A N   1 
ATOM   247  C CA  . ASN A 1 63  ? 166.911 133.684 156.850 1.00 36.12  ? 63  ASN A CA  1 
ATOM   248  C C   . ASN A 1 63  ? 166.250 134.570 157.906 1.00 36.12  ? 63  ASN A C   1 
ATOM   249  O O   . ASN A 1 63  ? 166.915 135.261 158.681 1.00 36.12  ? 63  ASN A O   1 
ATOM   250  C CB  . ASN A 1 63  ? 168.435 133.700 156.992 1.00 36.12  ? 63  ASN A CB  1 
ATOM   251  C CG  . ASN A 1 63  ? 169.070 132.383 156.592 1.00 36.12  ? 63  ASN A CG  1 
ATOM   252  O OD1 . ASN A 1 63  ? 168.695 131.323 157.092 1.00 36.12  ? 63  ASN A OD1 1 
ATOM   253  N ND2 . ASN A 1 63  ? 170.039 132.445 155.685 1.00 36.12  ? 63  ASN A ND2 1 
ATOM   254  N N   . LEU A 1 64  ? 164.921 134.548 157.928 1.00 35.39  ? 64  LEU A N   1 
ATOM   255  C CA  . LEU A 1 64  ? 164.129 135.282 158.903 1.00 35.39  ? 64  LEU A CA  1 
ATOM   256  C C   . LEU A 1 64  ? 163.406 134.292 159.806 1.00 35.39  ? 64  LEU A C   1 
ATOM   257  O O   . LEU A 1 64  ? 162.720 133.388 159.319 1.00 35.39  ? 64  LEU A O   1 
ATOM   258  C CB  . LEU A 1 64  ? 163.124 136.203 158.211 1.00 35.39  ? 64  LEU A CB  1 
ATOM   259  C CG  . LEU A 1 64  ? 163.680 137.405 157.448 1.00 35.39  ? 64  LEU A CG  1 
ATOM   260  C CD1 . LEU A 1 64  ? 162.647 137.939 156.479 1.00 35.39  ? 64  LEU A CD1 1 
ATOM   261  C CD2 . LEU A 1 64  ? 164.107 138.488 158.419 1.00 35.39  ? 64  LEU A CD2 1 
ATOM   262  N N   . THR A 1 65  ? 163.567 134.461 161.115 1.00 38.98  ? 65  THR A N   1 
ATOM   263  C CA  . THR A 1 65  ? 162.962 133.558 162.081 1.00 38.98  ? 65  THR A CA  1 
ATOM   264  C C   . THR A 1 65  ? 161.463 133.830 162.177 1.00 38.98  ? 65  THR A C   1 
ATOM   265  O O   . THR A 1 65  ? 160.997 134.940 161.906 1.00 38.98  ? 65  THR A O   1 
ATOM   266  C CB  . THR A 1 65  ? 163.640 133.722 163.445 1.00 38.98  ? 65  THR A CB  1 
ATOM   267  O OG1 . THR A 1 65  ? 165.057 133.578 163.285 1.00 38.98  ? 65  THR A OG1 1 
ATOM   268  C CG2 . THR A 1 65  ? 163.175 132.659 164.430 1.00 38.98  ? 65  THR A CG2 1 
ATOM   269  N N   . GLU A 1 66  ? 160.706 132.792 162.552 1.00 39.55  ? 66  GLU A N   1 
ATOM   270  C CA  . GLU A 1 66  ? 159.249 132.896 162.601 1.00 39.55  ? 66  GLU A CA  1 
ATOM   271  C C   . GLU A 1 66  ? 158.798 133.999 163.552 1.00 39.55  ? 66  GLU A C   1 
ATOM   272  O O   . GLU A 1 66  ? 157.835 134.719 163.265 1.00 39.55  ? 66  GLU A O   1 
ATOM   273  C CB  . GLU A 1 66  ? 158.636 131.552 163.005 1.00 39.55  ? 66  GLU A CB  1 
ATOM   274  C CG  . GLU A 1 66  ? 159.208 130.924 164.273 1.00 39.55  ? 66  GLU A CG  1 
ATOM   275  C CD  . GLU A 1 66  ? 160.460 130.106 164.022 1.00 39.55  ? 66  GLU A CD  1 
ATOM   276  O OE1 . GLU A 1 66  ? 160.891 130.015 162.854 1.00 39.55  ? 66  GLU A OE1 1 
ATOM   277  O OE2 . GLU A 1 66  ? 161.014 129.554 164.996 1.00 39.55  ? 66  GLU A OE2 1 
ATOM   278  N N   . ARG A 1 67  ? 159.485 134.145 164.687 1.00 40.91  ? 67  ARG A N   1 
ATOM   279  C CA  . ARG A 1 67  ? 159.207 135.243 165.606 1.00 40.91  ? 67  ARG A CA  1 
ATOM   280  C C   . ARG A 1 67  ? 159.260 136.585 164.885 1.00 40.91  ? 67  ARG A C   1 
ATOM   281  O O   . ARG A 1 67  ? 158.290 137.356 164.899 1.00 40.91  ? 67  ARG A O   1 
ATOM   282  C CB  . ARG A 1 67  ? 160.218 135.192 166.756 1.00 40.91  ? 67  ARG A CB  1 
ATOM   283  C CG  . ARG A 1 67  ? 159.717 134.480 168.006 1.00 40.91  ? 67  ARG A CG  1 
ATOM   284  C CD  . ARG A 1 67  ? 158.815 135.374 168.850 1.00 40.91  ? 67  ARG A CD  1 
ATOM   285  N NE  . ARG A 1 67  ? 159.506 136.581 169.298 1.00 40.91  ? 67  ARG A NE  1 
ATOM   286  C CZ  . ARG A 1 67  ? 159.386 137.780 168.745 1.00 40.91  ? 67  ARG A CZ  1 
ATOM   287  N NH1 . ARG A 1 67  ? 158.635 137.976 167.676 1.00 40.91  ? 67  ARG A NH1 1 
ATOM   288  N NH2 . ARG A 1 67  ? 160.047 138.807 169.271 1.00 40.91  ? 67  ARG A NH2 1 
ATOM   289  N N   . GLU A 1 68  ? 160.369 136.838 164.184 1.00 41.02  ? 68  GLU A N   1 
ATOM   290  C CA  . GLU A 1 68  ? 160.571 138.108 163.495 1.00 41.02  ? 68  GLU A CA  1 
ATOM   291  C C   . GLU A 1 68  ? 159.477 138.355 162.466 1.00 41.02  ? 68  GLU A C   1 
ATOM   292  O O   . GLU A 1 68  ? 158.821 139.404 162.479 1.00 41.02  ? 68  GLU A O   1 
ATOM   293  C CB  . GLU A 1 68  ? 161.943 138.109 162.822 1.00 41.02  ? 68  GLU A CB  1 
ATOM   294  C CG  . GLU A 1 68  ? 163.100 137.807 163.760 1.00 41.02  ? 68  GLU A CG  1 
ATOM   295  C CD  . GLU A 1 68  ? 164.356 137.392 163.018 1.00 41.02  ? 68  GLU A CD  1 
ATOM   296  O OE1 . GLU A 1 68  ? 164.287 137.212 161.784 1.00 41.02  ? 68  GLU A OE1 1 
ATOM   297  O OE2 . GLU A 1 68  ? 165.412 137.241 163.667 1.00 41.02  ? 68  GLU A OE2 1 
ATOM   298  N N   . VAL A 1 69  ? 159.245 137.377 161.587 1.00 40.18  ? 69  VAL A N   1 
ATOM   299  C CA  . VAL A 1 69  ? 158.263 137.541 160.518 1.00 40.18  ? 69  VAL A CA  1 
ATOM   300  C C   . VAL A 1 69  ? 156.877 137.766 161.103 1.00 40.18  ? 69  VAL A C   1 
ATOM   301  O O   . VAL A 1 69  ? 156.306 138.855 160.980 1.00 40.18  ? 69  VAL A O   1 
ATOM   302  C CB  . VAL A 1 69  ? 158.279 136.324 159.579 1.00 40.18  ? 69  VAL A CB  1 
ATOM   303  C CG1 . VAL A 1 69  ? 157.307 136.529 158.431 1.00 40.18  ? 69  VAL A CG1 1 
ATOM   304  C CG2 . VAL A 1 69  ? 159.673 136.091 159.060 1.00 40.18  ? 69  VAL A CG2 1 
ATOM   305  N N   . PHE A 1 70  ? 156.355 136.765 161.816 1.00 41.87  ? 70  PHE A N   1 
ATOM   306  C CA  . PHE A 1 70  ? 154.970 136.800 162.258 1.00 41.87  ? 70  PHE A CA  1 
ATOM   307  C C   . PHE A 1 70  ? 154.693 137.868 163.305 1.00 41.87  ? 70  PHE A C   1 
ATOM   308  O O   . PHE A 1 70  ? 153.519 138.139 163.572 1.00 41.87  ? 70  PHE A O   1 
ATOM   309  C CB  . PHE A 1 70  ? 154.550 135.432 162.797 1.00 41.87  ? 70  PHE A CB  1 
ATOM   310  C CG  . PHE A 1 70  ? 154.769 134.314 161.826 1.00 41.87  ? 70  PHE A CG  1 
ATOM   311  C CD1 . PHE A 1 70  ? 154.258 134.390 160.544 1.00 41.87  ? 70  PHE A CD1 1 
ATOM   312  C CD2 . PHE A 1 70  ? 155.481 133.188 162.190 1.00 41.87  ? 70  PHE A CD2 1 
ATOM   313  C CE1 . PHE A 1 70  ? 154.462 133.366 159.646 1.00 41.87  ? 70  PHE A CE1 1 
ATOM   314  C CE2 . PHE A 1 70  ? 155.686 132.164 161.295 1.00 41.87  ? 70  PHE A CE2 1 
ATOM   315  C CZ  . PHE A 1 70  ? 155.180 132.255 160.023 1.00 41.87  ? 70  PHE A CZ  1 
ATOM   316  N N   . ASN A 1 71  ? 155.715 138.493 163.899 1.00 43.44  ? 71  ASN A N   1 
ATOM   317  C CA  . ASN A 1 71  ? 155.433 139.564 164.840 1.00 43.44  ? 71  ASN A CA  1 
ATOM   318  C C   . ASN A 1 71  ? 155.736 140.958 164.317 1.00 43.44  ? 71  ASN A C   1 
ATOM   319  O O   . ASN A 1 71  ? 155.181 141.923 164.851 1.00 43.44  ? 71  ASN A O   1 
ATOM   320  C CB  . ASN A 1 71  ? 156.205 139.343 166.145 1.00 43.44  ? 71  ASN A CB  1 
ATOM   321  C CG  . ASN A 1 71  ? 155.508 138.366 167.068 1.00 43.44  ? 71  ASN A CG  1 
ATOM   322  O OD1 . ASN A 1 71  ? 155.997 137.263 167.309 1.00 43.44  ? 71  ASN A OD1 1 
ATOM   323  N ND2 . ASN A 1 71  ? 154.354 138.766 167.587 1.00 43.44  ? 71  ASN A ND2 1 
ATOM   324  N N   . GLU A 1 72  ? 156.573 141.103 163.298 1.00 41.58  ? 72  GLU A N   1 
ATOM   325  C CA  . GLU A 1 72  ? 156.818 142.466 162.849 1.00 41.58  ? 72  GLU A CA  1 
ATOM   326  C C   . GLU A 1 72  ? 156.576 142.668 161.363 1.00 41.58  ? 72  GLU A C   1 
ATOM   327  O O   . GLU A 1 72  ? 156.128 143.743 160.969 1.00 41.58  ? 72  GLU A O   1 
ATOM   328  C CB  . GLU A 1 72  ? 158.250 142.887 163.211 1.00 41.58  ? 72  GLU A CB  1 
ATOM   329  C CG  . GLU A 1 72  ? 158.405 143.333 164.656 1.00 41.58  ? 72  GLU A CG  1 
ATOM   330  C CD  . GLU A 1 72  ? 159.842 143.301 165.130 1.00 41.58  ? 72  GLU A CD  1 
ATOM   331  O OE1 . GLU A 1 72  ? 160.313 142.218 165.534 1.00 41.58  ? 72  GLU A OE1 1 
ATOM   332  O OE2 . GLU A 1 72  ? 160.501 144.361 165.101 1.00 41.58  ? 72  GLU A OE2 1 
ATOM   333  N N   . ILE A 1 73  ? 156.856 141.670 160.528 1.00 38.96  ? 73  ILE A N   1 
ATOM   334  C CA  . ILE A 1 73  ? 156.758 141.850 159.085 1.00 38.96  ? 73  ILE A CA  1 
ATOM   335  C C   . ILE A 1 73  ? 155.296 141.900 158.664 1.00 38.96  ? 73  ILE A C   1 
ATOM   336  O O   . ILE A 1 73  ? 154.840 142.895 158.089 1.00 38.96  ? 73  ILE A O   1 
ATOM   337  C CB  . ILE A 1 73  ? 157.510 140.732 158.341 1.00 38.96  ? 73  ILE A CB  1 
ATOM   338  C CG1 . ILE A 1 73  ? 159.019 140.890 158.531 1.00 38.96  ? 73  ILE A CG1 1 
ATOM   339  C CG2 . ILE A 1 73  ? 157.145 140.731 156.873 1.00 38.96  ? 73  ILE A CG2 1 
ATOM   340  C CD1 . ILE A 1 73  ? 159.824 139.736 157.990 1.00 38.96  ? 73  ILE A CD1 1 
ATOM   341  N N   . TYR A 1 74  ? 154.552 140.831 158.956 1.00 39.23  ? 74  TYR A N   1 
ATOM   342  C CA  . TYR A 1 74  ? 153.159 140.698 158.542 1.00 39.23  ? 74  TYR A CA  1 
ATOM   343  C C   . TYR A 1 74  ? 152.241 141.802 159.070 1.00 39.23  ? 74  TYR A C   1 
ATOM   344  O O   . TYR A 1 74  ? 151.450 142.341 158.287 1.00 39.23  ? 74  TYR A O   1 
ATOM   345  C CB  . TYR A 1 74  ? 152.609 139.329 158.953 1.00 39.23  ? 74  TYR A CB  1 
ATOM   346  C CG  . TYR A 1 74  ? 153.040 138.188 158.059 1.00 39.23  ? 74  TYR A CG  1 
ATOM   347  C CD1 . TYR A 1 74  ? 153.683 138.425 156.852 1.00 39.23  ? 74  TYR A CD1 1 
ATOM   348  C CD2 . TYR A 1 74  ? 152.784 136.872 158.416 1.00 39.23  ? 74  TYR A CD2 1 
ATOM   349  C CE1 . TYR A 1 74  ? 154.070 137.384 156.035 1.00 39.23  ? 74  TYR A CE1 1 
ATOM   350  C CE2 . TYR A 1 74  ? 153.164 135.827 157.605 1.00 39.23  ? 74  TYR A CE2 1 
ATOM   351  C CZ  . TYR A 1 74  ? 153.807 136.087 156.416 1.00 39.23  ? 74  TYR A CZ  1 
ATOM   352  O OH  . TYR A 1 74  ? 154.186 135.038 155.610 1.00 39.23  ? 74  TYR A OH  1 
ATOM   353  N N   . PRO A 1 75  ? 152.282 142.171 160.361 1.00 40.89  ? 75  PRO A N   1 
ATOM   354  C CA  . PRO A 1 75  ? 151.352 143.214 160.830 1.00 40.89  ? 75  PRO A CA  1 
ATOM   355  C C   . PRO A 1 75  ? 151.535 144.564 160.157 1.00 40.89  ? 75  PRO A C   1 
ATOM   356  O O   . PRO A 1 75  ? 150.597 145.376 160.156 1.00 40.89  ? 75  PRO A O   1 
ATOM   357  C CB  . PRO A 1 75  ? 151.641 143.289 162.336 1.00 40.89  ? 75  PRO A CB  1 
ATOM   358  C CG  . PRO A 1 75  ? 152.982 142.709 162.505 1.00 40.89  ? 75  PRO A CG  1 
ATOM   359  C CD  . PRO A 1 75  ? 153.073 141.633 161.483 1.00 40.89  ? 75  PRO A CD  1 
ATOM   360  N N   . VAL A 1 76  ? 152.713 144.839 159.590 1.00 39.88  ? 76  VAL A N   1 
ATOM   361  C CA  . VAL A 1 76  ? 152.905 146.092 158.866 1.00 39.88  ? 76  VAL A CA  1 
ATOM   362  C C   . VAL A 1 76  ? 152.016 146.139 157.634 1.00 39.88  ? 76  VAL A C   1 
ATOM   363  O O   . VAL A 1 76  ? 151.583 147.219 157.218 1.00 39.88  ? 76  VAL A O   1 
ATOM   364  C CB  . VAL A 1 76  ? 154.392 146.293 158.514 1.00 39.88  ? 76  VAL A CB  1 
ATOM   365  C CG1 . VAL A 1 76  ? 154.586 147.540 157.666 1.00 39.88  ? 76  VAL A CG1 1 
ATOM   366  C CG2 . VAL A 1 76  ? 155.197 146.437 159.781 1.00 39.88  ? 76  VAL A CG2 1 
ATOM   367  N N   . TRP A 1 77  ? 151.703 144.982 157.045 1.00 39.58  ? 77  TRP A N   1 
ATOM   368  C CA  . TRP A 1 77  ? 150.728 144.956 155.958 1.00 39.58  ? 77  TRP A CA  1 
ATOM   369  C C   . TRP A 1 77  ? 149.386 145.508 156.417 1.00 39.58  ? 77  TRP A C   1 
ATOM   370  O O   . TRP A 1 77  ? 148.798 146.366 155.750 1.00 39.58  ? 77  TRP A O   1 
ATOM   371  C CB  . TRP A 1 77  ? 150.558 143.534 155.428 1.00 39.58  ? 77  TRP A CB  1 
ATOM   372  C CG  . TRP A 1 77  ? 149.431 143.395 154.452 1.00 39.58  ? 77  TRP A CG  1 
ATOM   373  C CD1 . TRP A 1 77  ? 149.116 144.250 153.439 1.00 39.58  ? 77  TRP A CD1 1 
ATOM   374  C CD2 . TRP A 1 77  ? 148.454 142.348 154.411 1.00 39.58  ? 77  TRP A CD2 1 
ATOM   375  N NE1 . TRP A 1 77  ? 148.011 143.796 152.763 1.00 39.58  ? 77  TRP A NE1 1 
ATOM   376  C CE2 . TRP A 1 77  ? 147.585 142.631 153.341 1.00 39.58  ? 77  TRP A CE2 1 
ATOM   377  C CE3 . TRP A 1 77  ? 148.233 141.197 155.172 1.00 39.58  ? 77  TRP A CE3 1 
ATOM   378  C CZ2 . TRP A 1 77  ? 146.514 141.806 153.013 1.00 39.58  ? 77  TRP A CZ2 1 
ATOM   379  C CZ3 . TRP A 1 77  ? 147.168 140.381 154.845 1.00 39.58  ? 77  TRP A CZ3 1 
ATOM   380  C CH2 . TRP A 1 77  ? 146.324 140.688 153.775 1.00 39.58  ? 77  TRP A CH2 1 
ATOM   381  N N   . THR A 1 78  ? 148.897 145.038 157.567 1.00 40.43  ? 78  THR A N   1 
ATOM   382  C CA  . THR A 1 78  ? 147.628 145.527 158.094 1.00 40.43  ? 78  THR A CA  1 
ATOM   383  C C   . THR A 1 78  ? 147.703 147.008 158.438 1.00 40.43  ? 78  THR A C   1 
ATOM   384  O O   . THR A 1 78  ? 146.775 147.770 158.139 1.00 40.43  ? 78  THR A O   1 
ATOM   385  C CB  . THR A 1 78  ? 147.234 144.719 159.326 1.00 40.43  ? 78  THR A CB  1 
ATOM   386  O OG1 . THR A 1 78  ? 148.326 144.706 160.252 1.00 40.43  ? 78  THR A OG1 1 
ATOM   387  C CG2 . THR A 1 78  ? 146.913 143.294 158.932 1.00 40.43  ? 78  THR A CG2 1 
ATOM   388  N N   . TYR A 1 79  ? 148.801 147.434 159.068 1.00 42.81  ? 79  TYR A N   1 
ATOM   389  C CA  . TYR A 1 79  ? 148.935 148.837 159.453 1.00 42.81  ? 79  TYR A CA  1 
ATOM   390  C C   . TYR A 1 79  ? 148.938 149.739 158.227 1.00 42.81  ? 79  TYR A C   1 
ATOM   391  O O   . TYR A 1 79  ? 148.233 150.754 158.187 1.00 42.81  ? 79  TYR A O   1 
ATOM   392  C CB  . TYR A 1 79  ? 150.212 149.057 160.268 1.00 42.81  ? 79  TYR A CB  1 
ATOM   393  C CG  . TYR A 1 79  ? 150.412 148.112 161.430 1.00 42.81  ? 79  TYR A CG  1 
ATOM   394  C CD1 . TYR A 1 79  ? 149.334 147.543 162.091 1.00 42.81  ? 79  TYR A CD1 1 
ATOM   395  C CD2 . TYR A 1 79  ? 151.688 147.797 161.873 1.00 42.81  ? 79  TYR A CD2 1 
ATOM   396  C CE1 . TYR A 1 79  ? 149.522 146.680 163.145 1.00 42.81  ? 79  TYR A CE1 1 
ATOM   397  C CE2 . TYR A 1 79  ? 151.884 146.937 162.931 1.00 42.81  ? 79  TYR A CE2 1 
ATOM   398  C CZ  . TYR A 1 79  ? 150.797 146.384 163.563 1.00 42.81  ? 79  TYR A CZ  1 
ATOM   399  O OH  . TYR A 1 79  ? 150.989 145.527 164.618 1.00 42.81  ? 79  TYR A OH  1 
ATOM   400  N N   . SER A 1 80  ? 149.727 149.374 157.213 1.00 39.56  ? 80  SER A N   1 
ATOM   401  C CA  . SER A 1 80  ? 149.794 150.150 155.984 1.00 39.56  ? 80  SER A CA  1 
ATOM   402  C C   . SER A 1 80  ? 148.454 150.172 155.270 1.00 39.56  ? 80  SER A C   1 
ATOM   403  O O   . SER A 1 80  ? 148.021 151.222 154.784 1.00 39.56  ? 80  SER A O   1 
ATOM   404  C CB  . SER A 1 80  ? 150.874 149.575 155.071 1.00 39.56  ? 80  SER A CB  1 
ATOM   405  O OG  . SER A 1 80  ? 150.894 150.242 153.825 1.00 39.56  ? 80  SER A OG  1 
ATOM   406  N N   . TYR A 1 81  ? 147.780 149.023 155.201 1.00 40.26  ? 81  TYR A N   1 
ATOM   407  C CA  . TYR A 1 81  ? 146.491 148.951 154.524 1.00 40.26  ? 81  TYR A CA  1 
ATOM   408  C C   . TYR A 1 81  ? 145.465 149.846 155.210 1.00 40.26  ? 81  TYR A C   1 
ATOM   409  O O   . TYR A 1 81  ? 144.760 150.617 154.543 1.00 40.26  ? 81  TYR A O   1 
ATOM   410  C CB  . TYR A 1 81  ? 146.059 147.483 154.465 1.00 40.26  ? 81  TYR A CB  1 
ATOM   411  C CG  . TYR A 1 81  ? 144.783 147.165 153.722 1.00 40.26  ? 81  TYR A CG  1 
ATOM   412  C CD1 . TYR A 1 81  ? 144.322 147.975 152.701 1.00 40.26  ? 81  TYR A CD1 1 
ATOM   413  C CD2 . TYR A 1 81  ? 144.097 145.986 153.978 1.00 40.26  ? 81  TYR A CD2 1 
ATOM   414  C CE1 . TYR A 1 81  ? 143.165 147.662 152.015 1.00 40.26  ? 81  TYR A CE1 1 
ATOM   415  C CE2 . TYR A 1 81  ? 142.951 145.662 153.293 1.00 40.26  ? 81  TYR A CE2 1 
ATOM   416  C CZ  . TYR A 1 81  ? 142.489 146.503 152.310 1.00 40.26  ? 81  TYR A CZ  1 
ATOM   417  O OH  . TYR A 1 81  ? 141.343 146.189 151.616 1.00 40.26  ? 81  TYR A OH  1 
ATOM   418  N N   . LEU A 1 82  ? 145.425 149.818 156.546 1.00 44.30  ? 82  LEU A N   1 
ATOM   419  C CA  . LEU A 1 82  ? 144.543 150.715 157.288 1.00 44.30  ? 82  LEU A CA  1 
ATOM   420  C C   . LEU A 1 82  ? 144.881 152.175 157.008 1.00 44.30  ? 82  LEU A C   1 
ATOM   421  O O   . LEU A 1 82  ? 144.009 152.963 156.625 1.00 44.30  ? 82  LEU A O   1 
ATOM   422  C CB  . LEU A 1 82  ? 144.659 150.447 158.788 1.00 44.30  ? 82  LEU A CB  1 
ATOM   423  C CG  . LEU A 1 82  ? 143.949 151.436 159.728 1.00 44.30  ? 82  LEU A CG  1 
ATOM   424  C CD1 . LEU A 1 82  ? 142.543 151.809 159.257 1.00 44.30  ? 82  LEU A CD1 1 
ATOM   425  C CD2 . LEU A 1 82  ? 143.937 150.976 161.168 1.00 44.30  ? 82  LEU A CD2 1 
ATOM   426  N N   . VAL A 1 83  ? 146.148 152.554 157.194 1.00 43.96  ? 83  VAL A N   1 
ATOM   427  C CA  . VAL A 1 83  ? 146.488 153.974 157.167 1.00 43.96  ? 83  VAL A CA  1 
ATOM   428  C C   . VAL A 1 83  ? 146.393 154.525 155.750 1.00 43.96  ? 83  VAL A C   1 
ATOM   429  O O   . VAL A 1 83  ? 146.194 155.731 155.559 1.00 43.96  ? 83  VAL A O   1 
ATOM   430  C CB  . VAL A 1 83  ? 147.884 154.207 157.781 1.00 43.96  ? 83  VAL A CB  1 
ATOM   431  C CG1 . VAL A 1 83  ? 148.966 153.556 156.941 1.00 43.96  ? 83  VAL A CG1 1 
ATOM   432  C CG2 . VAL A 1 83  ? 148.158 155.695 157.979 1.00 43.96  ? 83  VAL A CG2 1 
ATOM   433  N N   . LEU A 1 84  ? 146.504 153.665 154.738 1.00 45.04  ? 84  LEU A N   1 
ATOM   434  C CA  . LEU A 1 84  ? 146.494 154.114 153.358 1.00 45.04  ? 84  LEU A CA  1 
ATOM   435  C C   . LEU A 1 84  ? 145.155 153.931 152.660 1.00 45.04  ? 84  LEU A C   1 
ATOM   436  O O   . LEU A 1 84  ? 144.999 154.426 151.541 1.00 45.04  ? 84  LEU A O   1 
ATOM   437  C CB  . LEU A 1 84  ? 147.576 153.386 152.559 1.00 45.04  ? 84  LEU A CB  1 
ATOM   438  C CG  . LEU A 1 84  ? 149.009 153.700 152.974 1.00 45.04  ? 84  LEU A CG  1 
ATOM   439  C CD1 . LEU A 1 84  ? 149.953 152.816 152.209 1.00 45.04  ? 84  LEU A CD1 1 
ATOM   440  C CD2 . LEU A 1 84  ? 149.332 155.164 152.734 1.00 45.04  ? 84  LEU A CD2 1 
ATOM   441  N N   . LEU A 1 85  ? 144.190 153.241 153.275 1.00 51.69  ? 85  LEU A N   1 
ATOM   442  C CA  . LEU A 1 85  ? 142.886 153.114 152.632 1.00 51.69  ? 85  LEU A CA  1 
ATOM   443  C C   . LEU A 1 85  ? 142.232 154.477 152.429 1.00 51.69  ? 85  LEU A C   1 
ATOM   444  O O   . LEU A 1 85  ? 141.637 154.737 151.377 1.00 51.69  ? 85  LEU A O   1 
ATOM   445  C CB  . LEU A 1 85  ? 141.988 152.187 153.453 1.00 51.69  ? 85  LEU A CB  1 
ATOM   446  C CG  . LEU A 1 85  ? 140.646 151.743 152.864 1.00 51.69  ? 85  LEU A CG  1 
ATOM   447  C CD1 . LEU A 1 85  ? 140.282 150.386 153.425 1.00 51.69  ? 85  LEU A CD1 1 
ATOM   448  C CD2 . LEU A 1 85  ? 139.530 152.736 153.162 1.00 51.69  ? 85  LEU A CD2 1 
ATOM   449  N N   . PHE A 1 86  ? 142.327 155.359 153.429 1.00 56.62  ? 86  PHE A N   1 
ATOM   450  C CA  . PHE A 1 86  ? 141.699 156.675 153.308 1.00 56.62  ? 86  PHE A CA  1 
ATOM   451  C C   . PHE A 1 86  ? 142.339 157.529 152.214 1.00 56.62  ? 86  PHE A C   1 
ATOM   452  O O   . PHE A 1 86  ? 141.604 158.010 151.330 1.00 56.62  ? 86  PHE A O   1 
ATOM   453  C CB  . PHE A 1 86  ? 141.703 157.366 154.677 1.00 56.62  ? 86  PHE A CB  1 
ATOM   454  C CG  . PHE A 1 86  ? 140.998 158.689 154.703 1.00 56.62  ? 86  PHE A CG  1 
ATOM   455  C CD1 . PHE A 1 86  ? 139.615 158.751 154.714 1.00 56.62  ? 86  PHE A CD1 1 
ATOM   456  C CD2 . PHE A 1 86  ? 141.718 159.871 154.748 1.00 56.62  ? 86  PHE A CD2 1 
ATOM   457  C CE1 . PHE A 1 86  ? 138.960 159.969 154.752 1.00 56.62  ? 86  PHE A CE1 1 
ATOM   458  C CE2 . PHE A 1 86  ? 141.071 161.093 154.785 1.00 56.62  ? 86  PHE A CE2 1 
ATOM   459  C CZ  . PHE A 1 86  ? 139.689 161.142 154.789 1.00 56.62  ? 86  PHE A CZ  1 
ATOM   460  N N   . PRO A 1 87  ? 143.663 157.755 152.190 1.00 52.74  ? 87  PRO A N   1 
ATOM   461  C CA  . PRO A 1 87  ? 144.229 158.550 151.088 1.00 52.74  ? 87  PRO A CA  1 
ATOM   462  C C   . PRO A 1 87  ? 144.041 157.916 149.724 1.00 52.74  ? 87  PRO A C   1 
ATOM   463  O O   . PRO A 1 87  ? 143.886 158.643 148.737 1.00 52.74  ? 87  PRO A O   1 
ATOM   464  C CB  . PRO A 1 87  ? 145.715 158.661 151.457 1.00 52.74  ? 87  PRO A CB  1 
ATOM   465  C CG  . PRO A 1 87  ? 145.970 157.519 152.337 1.00 52.74  ? 87  PRO A CG  1 
ATOM   466  C CD  . PRO A 1 87  ? 144.719 157.339 153.131 1.00 52.74  ? 87  PRO A CD  1 
ATOM   467  N N   . VAL A 1 88  ? 144.052 156.584 149.634 1.00 52.33  ? 88  VAL A N   1 
ATOM   468  C CA  . VAL A 1 88  ? 143.758 155.927 148.363 1.00 52.33  ? 88  VAL A CA  1 
ATOM   469  C C   . VAL A 1 88  ? 142.341 156.252 147.912 1.00 52.33  ? 88  VAL A C   1 
ATOM   470  O O   . VAL A 1 88  ? 142.103 156.564 146.739 1.00 52.33  ? 88  VAL A O   1 
ATOM   471  C CB  . VAL A 1 88  ? 143.982 154.408 148.478 1.00 52.33  ? 88  VAL A CB  1 
ATOM   472  C CG1 . VAL A 1 88  ? 143.253 153.681 147.368 1.00 52.33  ? 88  VAL A CG1 1 
ATOM   473  C CG2 . VAL A 1 88  ? 145.462 154.094 148.415 1.00 52.33  ? 88  VAL A CG2 1 
ATOM   474  N N   . PHE A 1 89  ? 141.381 156.196 148.837 1.00 56.88  ? 89  PHE A N   1 
ATOM   475  C CA  . PHE A 1 89  ? 139.999 156.499 148.485 1.00 56.88  ? 89  PHE A CA  1 
ATOM   476  C C   . PHE A 1 89  ? 139.851 157.941 148.018 1.00 56.88  ? 89  PHE A C   1 
ATOM   477  O O   . PHE A 1 89  ? 139.117 158.217 147.062 1.00 56.88  ? 89  PHE A O   1 
ATOM   478  C CB  . PHE A 1 89  ? 139.080 156.219 149.674 1.00 56.88  ? 89  PHE A CB  1 
ATOM   479  C CG  . PHE A 1 89  ? 137.619 156.229 149.326 1.00 56.88  ? 89  PHE A CG  1 
ATOM   480  C CD1 . PHE A 1 89  ? 136.881 157.398 149.405 1.00 56.88  ? 89  PHE A CD1 1 
ATOM   481  C CD2 . PHE A 1 89  ? 136.986 155.069 148.914 1.00 56.88  ? 89  PHE A CD2 1 
ATOM   482  C CE1 . PHE A 1 89  ? 135.538 157.409 149.083 1.00 56.88  ? 89  PHE A CE1 1 
ATOM   483  C CE2 . PHE A 1 89  ? 135.644 155.074 148.591 1.00 56.88  ? 89  PHE A CE2 1 
ATOM   484  C CZ  . PHE A 1 89  ? 134.919 156.246 148.676 1.00 56.88  ? 89  PHE A CZ  1 
ATOM   485  N N   . LEU A 1 90  ? 140.532 158.879 148.683 1.00 55.76  ? 90  LEU A N   1 
ATOM   486  C CA  . LEU A 1 90  ? 140.458 160.271 148.242 1.00 55.76  ? 90  LEU A CA  1 
ATOM   487  C C   . LEU A 1 90  ? 141.130 160.473 146.886 1.00 55.76  ? 90  LEU A C   1 
ATOM   488  O O   . LEU A 1 90  ? 140.580 161.155 146.011 1.00 55.76  ? 90  LEU A O   1 
ATOM   489  C CB  . LEU A 1 90  ? 141.069 161.204 149.290 1.00 55.76  ? 90  LEU A CB  1 
ATOM   490  C CG  . LEU A 1 90  ? 140.204 161.655 150.474 1.00 55.76  ? 90  LEU A CG  1 
ATOM   491  C CD1 . LEU A 1 90  ? 139.037 162.491 149.972 1.00 55.76  ? 90  LEU A CD1 1 
ATOM   492  C CD2 . LEU A 1 90  ? 139.695 160.500 151.312 1.00 55.76  ? 90  LEU A CD2 1 
ATOM   493  N N   . ALA A 1 91  ? 142.313 159.886 146.688 1.00 52.05  ? 91  ALA A N   1 
ATOM   494  C CA  . ALA A 1 91  ? 143.042 160.076 145.439 1.00 52.05  ? 91  ALA A CA  1 
ATOM   495  C C   . ALA A 1 91  ? 142.344 159.401 144.268 1.00 52.05  ? 91  ALA A C   1 
ATOM   496  O O   . ALA A 1 91  ? 142.538 159.805 143.117 1.00 52.05  ? 91  ALA A O   1 
ATOM   497  C CB  . ALA A 1 91  ? 144.469 159.547 145.577 1.00 52.05  ? 91  ALA A CB  1 
ATOM   498  N N   . THR A 1 92  ? 141.542 158.370 144.539 1.00 51.80  ? 92  THR A N   1 
ATOM   499  C CA  . THR A 1 92  ? 140.836 157.677 143.469 1.00 51.80  ? 92  THR A CA  1 
ATOM   500  C C   . THR A 1 92  ? 139.841 158.603 142.779 1.00 51.80  ? 92  THR A C   1 
ATOM   501  O O   . THR A 1 92  ? 139.814 158.699 141.548 1.00 51.80  ? 92  THR A O   1 
ATOM   502  C CB  . THR A 1 92  ? 140.133 156.447 144.038 1.00 51.80  ? 92  THR A CB  1 
ATOM   503  O OG1 . THR A 1 92  ? 141.113 155.560 144.590 1.00 51.80  ? 92  THR A OG1 1 
ATOM   504  C CG2 . THR A 1 92  ? 139.374 155.721 142.953 1.00 51.80  ? 92  THR A CG2 1 
ATOM   505  N N   . ASP A 1 93  ? 139.017 159.300 143.561 1.00 51.00  ? 93  ASP A N   1 
ATOM   506  C CA  . ASP A 1 93  ? 138.091 160.267 142.985 1.00 51.00  ? 93  ASP A CA  1 
ATOM   507  C C   . ASP A 1 93  ? 138.789 161.559 142.580 1.00 51.00  ? 93  ASP A C   1 
ATOM   508  O O   . ASP A 1 93  ? 138.353 162.217 141.629 1.00 51.00  ? 93  ASP A O   1 
ATOM   509  C CB  . ASP A 1 93  ? 136.962 160.565 143.972 1.00 51.00  ? 93  ASP A CB  1 
ATOM   510  C CG  . ASP A 1 93  ? 135.735 161.150 143.298 1.00 51.00  ? 93  ASP A CG  1 
ATOM   511  O OD1 . ASP A 1 93  ? 135.800 162.309 142.835 1.00 51.00  ? 93  ASP A OD1 1 
ATOM   512  O OD2 . ASP A 1 93  ? 134.703 160.451 143.233 1.00 51.00  ? 93  ASP A OD2 1 
ATOM   513  N N   . TYR A 1 94  ? 139.863 161.940 143.279 1.00 51.75  ? 94  TYR A N   1 
ATOM   514  C CA  . TYR A 1 94  ? 140.564 163.173 142.934 1.00 51.75  ? 94  TYR A CA  1 
ATOM   515  C C   . TYR A 1 94  ? 141.280 163.067 141.594 1.00 51.75  ? 94  TYR A C   1 
ATOM   516  O O   . TYR A 1 94  ? 141.374 164.061 140.865 1.00 51.75  ? 94  TYR A O   1 
ATOM   517  C CB  . TYR A 1 94  ? 141.558 163.542 144.034 1.00 51.75  ? 94  TYR A CB  1 
ATOM   518  C CG  . TYR A 1 94  ? 142.195 164.903 143.853 1.00 51.75  ? 94  TYR A CG  1 
ATOM   519  C CD1 . TYR A 1 94  ? 141.440 166.064 143.955 1.00 51.75  ? 94  TYR A CD1 1 
ATOM   520  C CD2 . TYR A 1 94  ? 143.552 165.025 143.581 1.00 51.75  ? 94  TYR A CD2 1 
ATOM   521  C CE1 . TYR A 1 94  ? 142.019 167.310 143.789 1.00 51.75  ? 94  TYR A CE1 1 
ATOM   522  C CE2 . TYR A 1 94  ? 144.139 166.266 143.414 1.00 51.75  ? 94  TYR A CE2 1 
ATOM   523  C CZ  . TYR A 1 94  ? 143.369 167.404 143.519 1.00 51.75  ? 94  TYR A CZ  1 
ATOM   524  O OH  . TYR A 1 94  ? 143.949 168.641 143.354 1.00 51.75  ? 94  TYR A OH  1 
ATOM   525  N N   . LEU A 1 95  ? 141.789 161.885 141.252 1.00 51.01  ? 95  LEU A N   1 
ATOM   526  C CA  . LEU A 1 95  ? 142.570 161.690 140.038 1.00 51.01  ? 95  LEU A CA  1 
ATOM   527  C C   . LEU A 1 95  ? 141.767 161.053 138.909 1.00 51.01  ? 95  LEU A C   1 
ATOM   528  O O   . LEU A 1 95  ? 142.358 160.609 137.920 1.00 51.01  ? 95  LEU A O   1 
ATOM   529  C CB  . LEU A 1 95  ? 143.807 160.845 140.343 1.00 51.01  ? 95  LEU A CB  1 
ATOM   530  C CG  . LEU A 1 95  ? 144.842 161.488 141.268 1.00 51.01  ? 95  LEU A CG  1 
ATOM   531  C CD1 . LEU A 1 95  ? 145.946 160.503 141.611 1.00 51.01  ? 95  LEU A CD1 1 
ATOM   532  C CD2 . LEU A 1 95  ? 145.420 162.744 140.639 1.00 51.01  ? 95  LEU A CD2 1 
ATOM   533  N N   . ARG A 1 96  ? 140.439 161.001 139.037 1.00 53.58  ? 96  ARG A N   1 
ATOM   534  C CA  . ARG A 1 96  ? 139.551 160.431 138.019 1.00 53.58  ? 96  ARG A CA  1 
ATOM   535  C C   . ARG A 1 96  ? 139.860 158.956 137.760 1.00 53.58  ? 96  ARG A C   1 
ATOM   536  O O   . ARG A 1 96  ? 139.778 158.477 136.628 1.00 53.58  ? 96  ARG A O   1 
ATOM   537  C CB  . ARG A 1 96  ? 139.599 161.237 136.719 1.00 53.58  ? 96  ARG A CB  1 
ATOM   538  C CG  . ARG A 1 96  ? 138.671 162.443 136.700 1.00 53.58  ? 96  ARG A CG  1 
ATOM   539  C CD  . ARG A 1 96  ? 137.227 162.038 136.961 1.00 53.58  ? 96  ARG A CD  1 
ATOM   540  N NE  . ARG A 1 96  ? 136.368 163.192 137.198 1.00 53.58  ? 96  ARG A NE  1 
ATOM   541  C CZ  . ARG A 1 96  ? 135.198 163.140 137.820 1.00 53.58  ? 96  ARG A CZ  1 
ATOM   542  N NH1 . ARG A 1 96  ? 134.711 162.001 138.285 1.00 53.58  ? 96  ARG A NH1 1 
ATOM   543  N NH2 . ARG A 1 96  ? 134.497 164.260 137.980 1.00 53.58  ? 96  ARG A NH2 1 
ATOM   544  N N   . TYR A 1 97  ? 140.254 158.246 138.818 1.00 51.12  ? 97  TYR A N   1 
ATOM   545  C CA  . TYR A 1 97  ? 140.265 156.785 138.893 1.00 51.12  ? 97  TYR A CA  1 
ATOM   546  C C   . TYR A 1 97  ? 141.327 156.116 138.024 1.00 51.12  ? 97  TYR A C   1 
ATOM   547  O O   . TYR A 1 97  ? 141.533 154.903 138.136 1.00 51.12  ? 97  TYR A O   1 
ATOM   548  C CB  . TYR A 1 97  ? 138.890 156.201 138.525 1.00 51.12  ? 97  TYR A CB  1 
ATOM   549  C CG  . TYR A 1 97  ? 137.685 156.857 139.175 1.00 51.12  ? 97  TYR A CG  1 
ATOM   550  C CD1 . TYR A 1 97  ? 137.205 156.410 140.397 1.00 51.12  ? 97  TYR A CD1 1 
ATOM   551  C CD2 . TYR A 1 97  ? 136.992 157.882 138.541 1.00 51.12  ? 97  TYR A CD2 1 
ATOM   552  C CE1 . TYR A 1 97  ? 136.101 156.991 140.991 1.00 51.12  ? 97  TYR A CE1 1 
ATOM   553  C CE2 . TYR A 1 97  ? 135.887 158.470 139.126 1.00 51.12  ? 97  TYR A CE2 1 
ATOM   554  C CZ  . TYR A 1 97  ? 135.444 158.019 140.351 1.00 51.12  ? 97  TYR A CZ  1 
ATOM   555  O OH  . TYR A 1 97  ? 134.342 158.600 140.935 1.00 51.12  ? 97  TYR A OH  1 
ATOM   556  N N   . LYS A 1 98  ? 142.003 156.867 137.158 1.00 50.15  ? 98  LYS A N   1 
ATOM   557  C CA  . LYS A 1 98  ? 142.974 156.232 136.269 1.00 50.15  ? 98  LYS A CA  1 
ATOM   558  C C   . LYS A 1 98  ? 144.356 156.011 136.887 1.00 50.15  ? 98  LYS A C   1 
ATOM   559  O O   . LYS A 1 98  ? 144.874 154.889 136.812 1.00 50.15  ? 98  LYS A O   1 
ATOM   560  C CB  . LYS A 1 98  ? 143.116 157.026 134.968 1.00 50.15  ? 98  LYS A CB  1 
ATOM   561  C CG  . LYS A 1 98  ? 144.004 156.335 133.945 1.00 50.15  ? 98  LYS A CG  1 
ATOM   562  C CD  . LYS A 1 98  ? 143.724 156.816 132.533 1.00 50.15  ? 98  LYS A CD  1 
ATOM   563  C CE  . LYS A 1 98  ? 144.608 156.094 131.529 1.00 50.15  ? 98  LYS A CE  1 
ATOM   564  N NZ  . LYS A 1 98  ? 144.432 156.610 130.144 1.00 50.15  ? 98  LYS A NZ  1 
ATOM   565  N N   . PRO A 1 99  ? 145.001 157.022 137.492 1.00 45.43  ? 99  PRO A N   1 
ATOM   566  C CA  . PRO A 1 99  ? 146.388 156.817 137.943 1.00 45.43  ? 99  PRO A CA  1 
ATOM   567  C C   . PRO A 1 99  ? 146.519 155.857 139.107 1.00 45.43  ? 99  PRO A C   1 
ATOM   568  O O   . PRO A 1 99  ? 147.614 155.328 139.327 1.00 45.43  ? 99  PRO A O   1 
ATOM   569  C CB  . PRO A 1 99  ? 146.852 158.230 138.335 1.00 45.43  ? 99  PRO A CB  1 
ATOM   570  C CG  . PRO A 1 99  ? 145.833 159.157 137.761 1.00 45.43  ? 99  PRO A CG  1 
ATOM   571  C CD  . PRO A 1 99  ? 144.560 158.394 137.794 1.00 45.43  ? 99  PRO A CD  1 
ATOM   572  N N   . VAL A 1 100 ? 145.445 155.619 139.863 1.00 43.49  ? 100 VAL A N   1 
ATOM   573  C CA  . VAL A 1 100 ? 145.513 154.689 140.984 1.00 43.49  ? 100 VAL A CA  1 
ATOM   574  C C   . VAL A 1 100 ? 145.762 153.263 140.505 1.00 43.49  ? 100 VAL A C   1 
ATOM   575  O O   . VAL A 1 100 ? 146.406 152.470 141.202 1.00 43.49  ? 100 VAL A O   1 
ATOM   576  C CB  . VAL A 1 100 ? 144.232 154.801 141.826 1.00 43.49  ? 100 VAL A CB  1 
ATOM   577  C CG1 . VAL A 1 100 ? 144.113 156.196 142.403 1.00 43.49  ? 100 VAL A CG1 1 
ATOM   578  C CG2 . VAL A 1 100 ? 143.024 154.516 140.961 1.00 43.49  ? 100 VAL A CG2 1 
ATOM   579  N N   . VAL A 1 101 ? 145.275 152.912 139.315 1.00 40.22  ? 101 VAL A N   1 
ATOM   580  C CA  . VAL A 1 101 ? 145.543 151.589 138.764 1.00 40.22  ? 101 VAL A CA  1 
ATOM   581  C C   . VAL A 1 101 ? 147.031 151.421 138.476 1.00 40.22  ? 101 VAL A C   1 
ATOM   582  O O   . VAL A 1 101 ? 147.632 150.387 138.801 1.00 40.22  ? 101 VAL A O   1 
ATOM   583  C CB  . VAL A 1 101 ? 144.689 151.365 137.505 1.00 40.22  ? 101 VAL A CB  1 
ATOM   584  C CG1 . VAL A 1 101 ? 145.033 150.041 136.864 1.00 40.22  ? 101 VAL A CG1 1 
ATOM   585  C CG2 . VAL A 1 101 ? 143.211 151.428 137.852 1.00 40.22  ? 101 VAL A CG2 1 
ATOM   586  N N   . LEU A 1 102 ? 147.651 152.432 137.866 1.00 36.88  ? 102 LEU A N   1 
ATOM   587  C CA  . LEU A 1 102 ? 149.088 152.373 137.631 1.00 36.88  ? 102 LEU A CA  1 
ATOM   588  C C   . LEU A 1 102 ? 149.866 152.419 138.937 1.00 36.88  ? 102 LEU A C   1 
ATOM   589  O O   . LEU A 1 102 ? 150.947 151.832 139.032 1.00 36.88  ? 102 LEU A O   1 
ATOM   590  C CB  . LEU A 1 102 ? 149.517 153.512 136.709 1.00 36.88  ? 102 LEU A CB  1 
ATOM   591  C CG  . LEU A 1 102 ? 149.147 153.305 135.244 1.00 36.88  ? 102 LEU A CG  1 
ATOM   592  C CD1 . LEU A 1 102 ? 149.494 154.529 134.415 1.00 36.88  ? 102 LEU A CD1 1 
ATOM   593  C CD2 . LEU A 1 102 ? 149.848 152.076 134.712 1.00 36.88  ? 102 LEU A CD2 1 
ATOM   594  N N   . LEU A 1 103 ? 149.337 153.112 139.946 1.00 36.59  ? 103 LEU A N   1 
ATOM   595  C CA  . LEU A 1 103 ? 149.950 153.085 141.269 1.00 36.59  ? 103 LEU A CA  1 
ATOM   596  C C   . LEU A 1 103 ? 149.946 151.673 141.839 1.00 36.59  ? 103 LEU A C   1 
ATOM   597  O O   . LEU A 1 103 ? 150.945 151.222 142.411 1.00 36.59  ? 103 LEU A O   1 
ATOM   598  C CB  . LEU A 1 103 ? 149.214 154.049 142.199 1.00 36.59  ? 103 LEU A CB  1 
ATOM   599  C CG  . LEU A 1 103 ? 149.820 154.361 143.568 1.00 36.59  ? 103 LEU A CG  1 
ATOM   600  C CD1 . LEU A 1 103 ? 151.234 154.905 143.434 1.00 36.59  ? 103 LEU A CD1 1 
ATOM   601  C CD2 . LEU A 1 103 ? 148.936 155.346 144.315 1.00 36.59  ? 103 LEU A CD2 1 
ATOM   602  N N   . GLN A 1 104 ? 148.829 150.960 141.680 1.00 33.76  ? 104 GLN A N   1 
ATOM   603  C CA  . GLN A 1 104 ? 148.752 149.565 142.104 1.00 33.76  ? 104 GLN A CA  1 
ATOM   604  C C   . GLN A 1 104 ? 149.758 148.706 141.351 1.00 33.76  ? 104 GLN A C   1 
ATOM   605  O O   . GLN A 1 104 ? 150.450 147.870 141.946 1.00 33.76  ? 104 GLN A O   1 
ATOM   606  C CB  . GLN A 1 104 ? 147.337 149.033 141.889 1.00 33.76  ? 104 GLN A CB  1 
ATOM   607  C CG  . GLN A 1 104 ? 147.069 147.688 142.533 1.00 33.76  ? 104 GLN A CG  1 
ATOM   608  C CD  . GLN A 1 104 ? 147.098 146.553 141.543 1.00 33.76  ? 104 GLN A CD  1 
ATOM   609  O OE1 . GLN A 1 104 ? 147.470 146.735 140.386 1.00 33.76  ? 104 GLN A OE1 1 
ATOM   610  N NE2 . GLN A 1 104 ? 146.690 145.372 141.986 1.00 33.76  ? 104 GLN A NE2 1 
ATOM   611  N N   . GLY A 1 105 ? 149.850 148.899 140.035 1.00 31.63  ? 105 GLY A N   1 
ATOM   612  C CA  . GLY A 1 105 ? 150.800 148.125 139.251 1.00 31.63  ? 105 GLY A CA  1 
ATOM   613  C C   . GLY A 1 105 ? 152.241 148.375 139.658 1.00 31.63  ? 105 GLY A C   1 
ATOM   614  O O   . GLY A 1 105 ? 153.028 147.438 139.809 1.00 31.63  ? 105 GLY A O   1 
ATOM   615  N N   . LEU A 1 106 ? 152.601 149.645 139.853 1.00 32.14  ? 106 LEU A N   1 
ATOM   616  C CA  . LEU A 1 106 ? 153.962 149.990 140.252 1.00 32.14  ? 106 LEU A CA  1 
ATOM   617  C C   . LEU A 1 106 ? 154.278 149.478 141.652 1.00 32.14  ? 106 LEU A C   1 
ATOM   618  O O   . LEU A 1 106 ? 155.393 149.005 141.908 1.00 32.14  ? 106 LEU A O   1 
ATOM   619  C CB  . LEU A 1 106 ? 154.155 151.505 140.171 1.00 32.14  ? 106 LEU A CB  1 
ATOM   620  C CG  . LEU A 1 106 ? 155.525 152.066 140.551 1.00 32.14  ? 106 LEU A CG  1 
ATOM   621  C CD1 . LEU A 1 106 ? 156.629 151.388 139.759 1.00 32.14  ? 106 LEU A CD1 1 
ATOM   622  C CD2 . LEU A 1 106 ? 155.554 153.567 140.328 1.00 32.14  ? 106 LEU A CD2 1 
ATOM   623  N N   . SER A 1 107 ? 153.314 149.571 142.574 1.00 29.43  ? 107 SER A N   1 
ATOM   624  C CA  . SER A 1 107 ? 153.520 149.047 143.918 1.00 29.43  ? 107 SER A CA  1 
ATOM   625  C C   . SER A 1 107 ? 153.715 147.539 143.895 1.00 29.43  ? 107 SER A C   1 
ATOM   626  O O   . SER A 1 107 ? 154.573 147.009 144.606 1.00 29.43  ? 107 SER A O   1 
ATOM   627  C CB  . SER A 1 107 ? 152.343 149.422 144.813 1.00 29.43  ? 107 SER A CB  1 
ATOM   628  O OG  . SER A 1 107 ? 151.124 148.983 144.250 1.00 29.43  ? 107 SER A OG  1 
ATOM   629  N N   . LEU A 1 108 ? 152.936 146.830 143.076 1.00 28.06  ? 108 LEU A N   1 
ATOM   630  C CA  . LEU A 1 108 ? 153.135 145.390 142.947 1.00 28.06  ? 108 LEU A CA  1 
ATOM   631  C C   . LEU A 1 108 ? 154.499 145.073 142.346 1.00 28.06  ? 108 LEU A C   1 
ATOM   632  O O   . LEU A 1 108 ? 155.181 144.143 142.790 1.00 28.06  ? 108 LEU A O   1 
ATOM   633  C CB  . LEU A 1 108 ? 152.014 144.780 142.108 1.00 28.06  ? 108 LEU A CB  1 
ATOM   634  C CG  . LEU A 1 108 ? 150.831 144.219 142.899 1.00 28.06  ? 108 LEU A CG  1 
ATOM   635  C CD1 . LEU A 1 108 ? 149.750 143.725 141.962 1.00 28.06  ? 108 LEU A CD1 1 
ATOM   636  C CD2 . LEU A 1 108 ? 151.277 143.105 143.822 1.00 28.06  ? 108 LEU A CD2 1 
ATOM   637  N N   . ILE A 1 109 ? 154.922 145.844 141.342 1.00 29.44  ? 109 ILE A N   1 
ATOM   638  C CA  . ILE A 1 109 ? 156.214 145.589 140.707 1.00 29.44  ? 109 ILE A CA  1 
ATOM   639  C C   . ILE A 1 109 ? 157.349 145.778 141.708 1.00 29.44  ? 109 ILE A C   1 
ATOM   640  O O   . ILE A 1 109 ? 158.245 144.932 141.825 1.00 29.44  ? 109 ILE A O   1 
ATOM   641  C CB  . ILE A 1 109 ? 156.393 146.489 139.471 1.00 29.44  ? 109 ILE A CB  1 
ATOM   642  C CG1 . ILE A 1 109 ? 155.610 145.929 138.286 1.00 29.44  ? 109 ILE A CG1 1 
ATOM   643  C CG2 . ILE A 1 109 ? 157.863 146.614 139.105 1.00 29.44  ? 109 ILE A CG2 1 
ATOM   644  C CD1 . ILE A 1 109 ? 155.813 146.707 137.013 1.00 29.44  ? 109 ILE A CD1 1 
ATOM   645  N N   . VAL A 1 110 ? 157.324 146.885 142.455 1.00 30.84  ? 110 VAL A N   1 
ATOM   646  C CA  . VAL A 1 110 ? 158.396 147.138 143.413 1.00 30.84  ? 110 VAL A CA  1 
ATOM   647  C C   . VAL A 1 110 ? 158.328 146.143 144.568 1.00 30.84  ? 110 VAL A C   1 
ATOM   648  O O   . VAL A 1 110 ? 159.363 145.729 145.105 1.00 30.84  ? 110 VAL A O   1 
ATOM   649  C CB  . VAL A 1 110 ? 158.366 148.602 143.897 1.00 30.84  ? 110 VAL A CB  1 
ATOM   650  C CG1 . VAL A 1 110 ? 157.106 148.907 144.678 1.00 30.84  ? 110 VAL A CG1 1 
ATOM   651  C CG2 . VAL A 1 110 ? 159.601 148.912 144.730 1.00 30.84  ? 110 VAL A CG2 1 
ATOM   652  N N   . THR A 1 111 ? 157.118 145.719 144.948 1.00 28.84  ? 111 THR A N   1 
ATOM   653  C CA  . THR A 1 111 ? 156.973 144.689 145.969 1.00 28.84  ? 111 THR A CA  1 
ATOM   654  C C   . THR A 1 111 ? 157.638 143.392 145.537 1.00 28.84  ? 111 THR A C   1 
ATOM   655  O O   . THR A 1 111 ? 158.396 142.787 146.303 1.00 28.84  ? 111 THR A O   1 
ATOM   656  C CB  . THR A 1 111 ? 155.490 144.450 146.253 1.00 28.84  ? 111 THR A CB  1 
ATOM   657  O OG1 . THR A 1 111 ? 154.920 145.612 146.863 1.00 28.84  ? 111 THR A OG1 1 
ATOM   658  C CG2 . THR A 1 111 ? 155.301 143.251 147.166 1.00 28.84  ? 111 THR A CG2 1 
ATOM   659  N N   . TRP A 1 112 ? 157.386 142.961 144.301 1.00 31.89  ? 112 TRP A N   1 
ATOM   660  C CA  . TRP A 1 112 ? 157.913 141.675 143.861 1.00 31.89  ? 112 TRP A CA  1 
ATOM   661  C C   . TRP A 1 112 ? 159.389 141.768 143.492 1.00 31.89  ? 112 TRP A C   1 
ATOM   662  O O   . TRP A 1 112 ? 160.082 140.747 143.438 1.00 31.89  ? 112 TRP A O   1 
ATOM   663  C CB  . TRP A 1 112 ? 157.077 141.137 142.702 1.00 31.89  ? 112 TRP A CB  1 
ATOM   664  C CG  . TRP A 1 112 ? 155.722 140.706 143.161 1.00 31.89  ? 112 TRP A CG  1 
ATOM   665  C CD1 . TRP A 1 112 ? 154.538 141.339 142.936 1.00 31.89  ? 112 TRP A CD1 1 
ATOM   666  C CD2 . TRP A 1 112 ? 155.421 139.568 143.967 1.00 31.89  ? 112 TRP A CD2 1 
ATOM   667  N NE1 . TRP A 1 112 ? 153.513 140.656 143.539 1.00 31.89  ? 112 TRP A NE1 1 
ATOM   668  C CE2 . TRP A 1 112 ? 154.031 139.564 144.180 1.00 31.89  ? 112 TRP A CE2 1 
ATOM   669  C CE3 . TRP A 1 112 ? 156.192 138.547 144.522 1.00 31.89  ? 112 TRP A CE3 1 
ATOM   670  C CZ2 . TRP A 1 112 ? 153.395 138.579 144.922 1.00 31.89  ? 112 TRP A CZ2 1 
ATOM   671  C CZ3 . TRP A 1 112 ? 155.562 137.575 145.259 1.00 31.89  ? 112 TRP A CZ3 1 
ATOM   672  C CH2 . TRP A 1 112 ? 154.176 137.594 145.453 1.00 31.89  ? 112 TRP A CH2 1 
ATOM   673  N N   . PHE A 1 113 ? 159.893 142.977 143.235 1.00 31.59  ? 113 PHE A N   1 
ATOM   674  C CA  . PHE A 1 113 ? 161.337 143.132 143.084 1.00 31.59  ? 113 PHE A CA  1 
ATOM   675  C C   . PHE A 1 113 ? 162.038 143.072 144.434 1.00 31.59  ? 113 PHE A C   1 
ATOM   676  O O   . PHE A 1 113 ? 163.041 142.364 144.597 1.00 31.59  ? 113 PHE A O   1 
ATOM   677  C CB  . PHE A 1 113 ? 161.675 144.441 142.375 1.00 31.59  ? 113 PHE A CB  1 
ATOM   678  C CG  . PHE A 1 113 ? 163.136 144.585 142.060 1.00 31.59  ? 113 PHE A CG  1 
ATOM   679  C CD1 . PHE A 1 113 ? 163.683 143.960 140.953 1.00 31.59  ? 113 PHE A CD1 1 
ATOM   680  C CD2 . PHE A 1 113 ? 163.967 145.323 142.886 1.00 31.59  ? 113 PHE A CD2 1 
ATOM   681  C CE1 . PHE A 1 113 ? 165.027 144.080 140.667 1.00 31.59  ? 113 PHE A CE1 1 
ATOM   682  C CE2 . PHE A 1 113 ? 165.313 145.447 142.605 1.00 31.59  ? 113 PHE A CE2 1 
ATOM   683  C CZ  . PHE A 1 113 ? 165.843 144.825 141.493 1.00 31.59  ? 113 PHE A CZ  1 
ATOM   684  N N   . MET A 1 114 ? 161.529 143.819 145.415 1.00 29.96  ? 114 MET A N   1 
ATOM   685  C CA  . MET A 1 114 ? 162.116 143.800 146.745 1.00 29.96  ? 114 MET A CA  1 
ATOM   686  C C   . MET A 1 114 ? 161.980 142.432 147.397 1.00 29.96  ? 114 MET A C   1 
ATOM   687  O O   . MET A 1 114 ? 162.815 142.067 148.229 1.00 29.96  ? 114 MET A O   1 
ATOM   688  C CB  . MET A 1 114 ? 161.467 144.887 147.603 1.00 29.96  ? 114 MET A CB  1 
ATOM   689  C CG  . MET A 1 114 ? 162.068 145.068 148.979 1.00 29.96  ? 114 MET A CG  1 
ATOM   690  S SD  . MET A 1 114 ? 161.236 146.378 149.891 1.00 29.96  ? 114 MET A SD  1 
ATOM   691  C CE  . MET A 1 114 ? 161.822 147.825 149.022 1.00 29.96  ? 114 MET A CE  1 
ATOM   692  N N   . LEU A 1 115 ? 160.961 141.658 147.019 1.00 30.26  ? 115 LEU A N   1 
ATOM   693  C CA  . LEU A 1 115 ? 160.846 140.297 147.526 1.00 30.26  ? 115 LEU A CA  1 
ATOM   694  C C   . LEU A 1 115 ? 161.880 139.378 146.885 1.00 30.26  ? 115 LEU A C   1 
ATOM   695  O O   . LEU A 1 115 ? 162.247 138.354 147.473 1.00 30.26  ? 115 LEU A O   1 
ATOM   696  C CB  . LEU A 1 115 ? 159.413 139.802 147.310 1.00 30.26  ? 115 LEU A CB  1 
ATOM   697  C CG  . LEU A 1 115 ? 158.919 138.506 147.950 1.00 30.26  ? 115 LEU A CG  1 
ATOM   698  C CD1 . LEU A 1 115 ? 157.429 138.603 148.191 1.00 30.26  ? 115 LEU A CD1 1 
ATOM   699  C CD2 . LEU A 1 115 ? 159.199 137.331 147.055 1.00 30.26  ? 115 LEU A CD2 1 
ATOM   700  N N   . LEU A 1 116 ? 162.362 139.724 145.689 1.00 32.07  ? 116 LEU A N   1 
ATOM   701  C CA  . LEU A 1 116 ? 163.515 139.033 145.123 1.00 32.07  ? 116 LEU A CA  1 
ATOM   702  C C   . LEU A 1 116 ? 164.813 139.440 145.807 1.00 32.07  ? 116 LEU A C   1 
ATOM   703  O O   . LEU A 1 116 ? 165.661 138.587 146.088 1.00 32.07  ? 116 LEU A O   1 
ATOM   704  C CB  . LEU A 1 116 ? 163.616 139.299 143.621 1.00 32.07  ? 116 LEU A CB  1 
ATOM   705  C CG  . LEU A 1 116 ? 162.527 138.753 142.706 1.00 32.07  ? 116 LEU A CG  1 
ATOM   706  C CD1 . LEU A 1 116 ? 162.731 139.244 141.291 1.00 32.07  ? 116 LEU A CD1 1 
ATOM   707  C CD2 . LEU A 1 116 ? 162.611 137.250 142.731 1.00 32.07  ? 116 LEU A CD2 1 
ATOM   708  N N   . TYR A 1 117 ? 164.991 140.734 146.083 1.00 32.32  ? 117 TYR A N   1 
ATOM   709  C CA  . TYR A 1 117 ? 166.273 141.236 146.590 1.00 32.32  ? 117 TYR A CA  1 
ATOM   710  C C   . TYR A 1 117 ? 166.028 142.199 147.752 1.00 32.32  ? 117 TYR A C   1 
ATOM   711  O O   . TYR A 1 117 ? 165.862 143.404 147.547 1.00 32.32  ? 117 TYR A O   1 
ATOM   712  C CB  . TYR A 1 117 ? 167.070 141.900 145.475 1.00 32.32  ? 117 TYR A CB  1 
ATOM   713  N N   . ALA A 1 118 ? 166.019 141.653 148.968 1.00 31.29  ? 118 ALA A N   1 
ATOM   714  C CA  . ALA A 1 118 ? 166.039 142.422 150.206 1.00 31.29  ? 118 ALA A CA  1 
ATOM   715  C C   . ALA A 1 118 ? 166.324 141.470 151.356 1.00 31.29  ? 118 ALA A C   1 
ATOM   716  O O   . ALA A 1 118 ? 165.742 140.386 151.424 1.00 31.29  ? 118 ALA A O   1 
ATOM   717  C CB  . ALA A 1 118 ? 164.718 143.158 150.456 1.00 31.29  ? 118 ALA A CB  1 
ATOM   718  N N   . GLN A 1 119 ? 167.224 141.875 152.243 1.00 33.48  ? 119 GLN A N   1 
ATOM   719  C CA  . GLN A 1 119 ? 167.542 141.120 153.443 1.00 33.48  ? 119 GLN A CA  1 
ATOM   720  C C   . GLN A 1 119 ? 167.167 141.943 154.673 1.00 33.48  ? 119 GLN A C   1 
ATOM   721  O O   . GLN A 1 119 ? 166.591 143.032 154.569 1.00 33.48  ? 119 GLN A O   1 
ATOM   722  C CB  . GLN A 1 119 ? 169.022 140.729 153.449 1.00 33.48  ? 119 GLN A CB  1 
ATOM   723  C CG  . GLN A 1 119 ? 169.575 140.322 152.092 1.00 33.48  ? 119 GLN A CG  1 
ATOM   724  C CD  . GLN A 1 119 ? 168.769 139.223 151.427 1.00 33.48  ? 119 GLN A CD  1 
ATOM   725  O OE1 . GLN A 1 119 ? 168.316 138.284 152.080 1.00 33.48  ? 119 GLN A OE1 1 
ATOM   726  N NE2 . GLN A 1 119 ? 168.589 139.334 150.118 1.00 33.48  ? 119 GLN A NE2 1 
ATOM   727  N N   . GLY A 1 120 ? 167.494 141.416 155.848 1.00 36.22  ? 120 GLY A N   1 
ATOM   728  C CA  . GLY A 1 120 ? 167.217 142.154 157.061 1.00 36.22  ? 120 GLY A CA  1 
ATOM   729  C C   . GLY A 1 120 ? 165.733 142.189 157.395 1.00 36.22  ? 120 GLY A C   1 
ATOM   730  O O   . GLY A 1 120 ? 164.948 141.321 157.003 1.00 36.22  ? 120 GLY A O   1 
ATOM   731  N N   . LEU A 1 121 ? 165.355 143.228 158.138 1.00 35.85  ? 121 LEU A N   1 
ATOM   732  C CA  . LEU A 1 121 ? 163.991 143.384 158.630 1.00 35.85  ? 121 LEU A CA  1 
ATOM   733  C C   . LEU A 1 121 ? 163.318 144.647 158.119 1.00 35.85  ? 121 LEU A C   1 
ATOM   734  O O   . LEU A 1 121 ? 162.150 144.599 157.715 1.00 35.85  ? 121 LEU A O   1 
ATOM   735  C CB  . LEU A 1 121 ? 163.991 143.377 160.166 1.00 35.85  ? 121 LEU A CB  1 
ATOM   736  C CG  . LEU A 1 121 ? 162.626 143.334 160.851 1.00 35.85  ? 121 LEU A CG  1 
ATOM   737  C CD1 . LEU A 1 121 ? 162.076 141.920 160.848 1.00 35.85  ? 121 LEU A CD1 1 
ATOM   738  C CD2 . LEU A 1 121 ? 162.729 143.870 162.266 1.00 35.85  ? 121 LEU A CD2 1 
ATOM   739  N N   . LEU A 1 122 ? 164.021 145.783 158.133 1.00 36.74  ? 122 LEU A N   1 
ATOM   740  C CA  . LEU A 1 122 ? 163.412 147.042 157.716 1.00 36.74  ? 122 LEU A CA  1 
ATOM   741  C C   . LEU A 1 122 ? 162.991 146.993 156.254 1.00 36.74  ? 122 LEU A C   1 
ATOM   742  O O   . LEU A 1 122 ? 161.923 147.502 155.889 1.00 36.74  ? 122 LEU A O   1 
ATOM   743  C CB  . LEU A 1 122 ? 164.385 148.195 157.950 1.00 36.74  ? 122 LEU A CB  1 
ATOM   744  C CG  . LEU A 1 122 ? 165.118 148.194 159.290 1.00 36.74  ? 122 LEU A CG  1 
ATOM   745  C CD1 . LEU A 1 122 ? 166.205 149.256 159.303 1.00 36.74  ? 122 LEU A CD1 1 
ATOM   746  C CD2 . LEU A 1 122 ? 164.144 148.404 160.439 1.00 36.74  ? 122 LEU A CD2 1 
ATOM   747  N N   . ALA A 1 123 ? 163.822 146.390 155.402 1.00 34.00  ? 123 ALA A N   1 
ATOM   748  C CA  . ALA A 1 123 ? 163.482 146.286 153.989 1.00 34.00  ? 123 ALA A CA  1 
ATOM   749  C C   . ALA A 1 123 ? 162.200 145.491 153.792 1.00 34.00  ? 123 ALA A C   1 
ATOM   750  O O   . ALA A 1 123 ? 161.336 145.883 153.002 1.00 34.00  ? 123 ALA A O   1 
ATOM   751  C CB  . ALA A 1 123 ? 164.636 145.647 153.219 1.00 34.00  ? 123 ALA A CB  1 
ATOM   752  N N   . ILE A 1 124 ? 162.045 144.383 154.519 1.00 35.18  ? 124 ILE A N   1 
ATOM   753  C CA  . ILE A 1 124 ? 160.834 143.579 154.386 1.00 35.18  ? 124 ILE A CA  1 
ATOM   754  C C   . ILE A 1 124 ? 159.630 144.304 154.981 1.00 35.18  ? 124 ILE A C   1 
ATOM   755  O O   . ILE A 1 124 ? 158.499 144.138 154.505 1.00 35.18  ? 124 ILE A O   1 
ATOM   756  C CB  . ILE A 1 124 ? 161.047 142.198 155.027 1.00 35.18  ? 124 ILE A CB  1 
ATOM   757  C CG1 . ILE A 1 124 ? 162.340 141.576 154.509 1.00 35.18  ? 124 ILE A CG1 1 
ATOM   758  C CG2 . ILE A 1 124 ? 159.903 141.281 154.682 1.00 35.18  ? 124 ILE A CG2 1 
ATOM   759  C CD1 . ILE A 1 124 ? 162.332 141.315 153.022 1.00 35.18  ? 124 ILE A CD1 1 
ATOM   760  N N   . GLN A 1 125 ? 159.837 145.108 156.026 1.00 36.11  ? 125 GLN A N   1 
ATOM   761  C CA  . GLN A 1 125 ? 158.742 145.921 156.549 1.00 36.11  ? 125 GLN A CA  1 
ATOM   762  C C   . GLN A 1 125 ? 158.260 146.928 155.511 1.00 36.11  ? 125 GLN A C   1 
ATOM   763  O O   . GLN A 1 125 ? 157.051 147.107 155.317 1.00 36.11  ? 125 GLN A O   1 
ATOM   764  C CB  . GLN A 1 125 ? 159.178 146.634 157.827 1.00 36.11  ? 125 GLN A CB  1 
ATOM   765  C CG  . GLN A 1 125 ? 159.442 145.708 158.995 1.00 36.11  ? 125 GLN A CG  1 
ATOM   766  C CD  . GLN A 1 125 ? 159.488 146.446 160.313 1.00 36.11  ? 125 GLN A CD  1 
ATOM   767  O OE1 . GLN A 1 125 ? 159.260 147.653 160.367 1.00 36.11  ? 125 GLN A OE1 1 
ATOM   768  N NE2 . GLN A 1 125 ? 159.790 145.726 161.385 1.00 36.11  ? 125 GLN A NE2 1 
ATOM   769  N N   . PHE A 1 126 ? 159.192 147.587 154.821 1.00 36.51  ? 126 PHE A N   1 
ATOM   770  C CA  . PHE A 1 126 ? 158.791 148.477 153.735 1.00 36.51  ? 126 PHE A CA  1 
ATOM   771  C C   . PHE A 1 126 ? 158.178 147.699 152.577 1.00 36.51  ? 126 PHE A C   1 
ATOM   772  O O   . PHE A 1 126 ? 157.314 148.224 151.866 1.00 36.51  ? 126 PHE A O   1 
ATOM   773  C CB  . PHE A 1 126 ? 159.979 149.313 153.261 1.00 36.51  ? 126 PHE A CB  1 
ATOM   774  C CG  . PHE A 1 126 ? 160.369 150.403 154.216 1.00 36.51  ? 126 PHE A CG  1 
ATOM   775  C CD1 . PHE A 1 126 ? 159.563 151.516 154.381 1.00 36.51  ? 126 PHE A CD1 1 
ATOM   776  C CD2 . PHE A 1 126 ? 161.543 150.321 154.945 1.00 36.51  ? 126 PHE A CD2 1 
ATOM   777  C CE1 . PHE A 1 126 ? 159.917 152.521 155.262 1.00 36.51  ? 126 PHE A CE1 1 
ATOM   778  C CE2 . PHE A 1 126 ? 161.902 151.320 155.827 1.00 36.51  ? 126 PHE A CE2 1 
ATOM   779  C CZ  . PHE A 1 126 ? 161.089 152.423 155.984 1.00 36.51  ? 126 PHE A CZ  1 
ATOM   780  N N   . LEU A 1 127 ? 158.607 146.452 152.377 1.00 31.50  ? 127 LEU A N   1 
ATOM   781  C CA  . LEU A 1 127 ? 157.984 145.585 151.381 1.00 31.50  ? 127 LEU A CA  1 
ATOM   782  C C   . LEU A 1 127 ? 156.517 145.343 151.701 1.00 31.50  ? 127 LEU A C   1 
ATOM   783  O O   . LEU A 1 127 ? 155.662 145.392 150.810 1.00 31.50  ? 127 LEU A O   1 
ATOM   784  C CB  . LEU A 1 127 ? 158.741 144.261 151.317 1.00 31.50  ? 127 LEU A CB  1 
ATOM   785  C CG  . LEU A 1 127 ? 158.324 143.144 150.366 1.00 31.50  ? 127 LEU A CG  1 
ATOM   786  C CD1 . LEU A 1 127 ? 159.560 142.376 150.020 1.00 31.50  ? 127 LEU A CD1 1 
ATOM   787  C CD2 . LEU A 1 127 ? 157.309 142.207 150.994 1.00 31.50  ? 127 LEU A CD2 1 
ATOM   788  N N   . GLU A 1 128 ? 156.212 145.058 152.967 1.00 34.53  ? 128 GLU A N   1 
ATOM   789  C CA  . GLU A 1 128 ? 154.821 144.869 153.366 1.00 34.53  ? 128 GLU A CA  1 
ATOM   790  C C   . GLU A 1 128 ? 154.051 146.182 153.319 1.00 34.53  ? 128 GLU A C   1 
ATOM   791  O O   . GLU A 1 128 ? 152.847 146.183 153.048 1.00 34.53  ? 128 GLU A O   1 
ATOM   792  C CB  . GLU A 1 128 ? 154.750 144.247 154.757 1.00 34.53  ? 128 GLU A CB  1 
ATOM   793  C CG  . GLU A 1 128 ? 155.057 142.762 154.773 1.00 34.53  ? 128 GLU A CG  1 
ATOM   794  C CD  . GLU A 1 128 ? 154.214 141.971 153.791 1.00 34.53  ? 128 GLU A CD  1 
ATOM   795  O OE1 . GLU A 1 128 ? 152.976 142.128 153.805 1.00 34.53  ? 128 GLU A OE1 1 
ATOM   796  O OE2 . GLU A 1 128 ? 154.788 141.188 153.007 1.00 34.53  ? 128 GLU A OE2 1 
ATOM   797  N N   . PHE A 1 129 ? 154.730 147.304 153.562 1.00 34.85  ? 129 PHE A N   1 
ATOM   798  C CA  . PHE A 1 129 ? 154.124 148.614 153.335 1.00 34.85  ? 129 PHE A CA  1 
ATOM   799  C C   . PHE A 1 129 ? 153.715 148.775 151.872 1.00 34.85  ? 129 PHE A C   1 
ATOM   800  O O   . PHE A 1 129 ? 152.617 149.262 151.570 1.00 34.85  ? 129 PHE A O   1 
ATOM   801  C CB  . PHE A 1 129 ? 155.119 149.701 153.761 1.00 34.85  ? 129 PHE A CB  1 
ATOM   802  C CG  . PHE A 1 129 ? 154.848 151.070 153.188 1.00 34.85  ? 129 PHE A CG  1 
ATOM   803  C CD1 . PHE A 1 129 ? 153.579 151.623 153.199 1.00 34.85  ? 129 PHE A CD1 1 
ATOM   804  C CD2 . PHE A 1 129 ? 155.879 151.798 152.622 1.00 34.85  ? 129 PHE A CD2 1 
ATOM   805  C CE1 . PHE A 1 129 ? 153.353 152.873 152.668 1.00 34.85  ? 129 PHE A CE1 1 
ATOM   806  C CE2 . PHE A 1 129 ? 155.654 153.049 152.088 1.00 34.85  ? 129 PHE A CE2 1 
ATOM   807  C CZ  . PHE A 1 129 ? 154.388 153.585 152.110 1.00 34.85  ? 129 PHE A CZ  1 
ATOM   808  N N   . PHE A 1 130 ? 154.587 148.363 150.950 1.00 30.44  ? 130 PHE A N   1 
ATOM   809  C CA  . PHE A 1 130 ? 154.272 148.480 149.531 1.00 30.44  ? 130 PHE A CA  1 
ATOM   810  C C   . PHE A 1 130 ? 153.169 147.508 149.135 1.00 30.44  ? 130 PHE A C   1 
ATOM   811  O O   . PHE A 1 130 ? 152.323 147.821 148.291 1.00 30.44  ? 130 PHE A O   1 
ATOM   812  C CB  . PHE A 1 130 ? 155.525 148.247 148.693 1.00 30.44  ? 130 PHE A CB  1 
ATOM   813  C CG  . PHE A 1 130 ? 156.282 149.502 148.386 1.00 30.44  ? 130 PHE A CG  1 
ATOM   814  C CD1 . PHE A 1 130 ? 155.658 150.563 147.756 1.00 30.44  ? 130 PHE A CD1 1 
ATOM   815  C CD2 . PHE A 1 130 ? 157.618 149.618 148.721 1.00 30.44  ? 130 PHE A CD2 1 
ATOM   816  C CE1 . PHE A 1 130 ? 156.349 151.720 147.476 1.00 30.44  ? 130 PHE A CE1 1 
ATOM   817  C CE2 . PHE A 1 130 ? 158.315 150.770 148.441 1.00 30.44  ? 130 PHE A CE2 1 
ATOM   818  C CZ  . PHE A 1 130 ? 157.680 151.824 147.818 1.00 30.44  ? 130 PHE A CZ  1 
ATOM   819  N N   . TYR A 1 131 ? 153.151 146.325 149.745 1.00 33.60  ? 131 TYR A N   1 
ATOM   820  C CA  . TYR A 1 131 ? 152.041 145.405 149.526 1.00 33.60  ? 131 TYR A CA  1 
ATOM   821  C C   . TYR A 1 131 ? 150.733 146.009 150.024 1.00 33.60  ? 131 TYR A C   1 
ATOM   822  O O   . TYR A 1 131 ? 149.674 145.815 149.419 1.00 33.60  ? 131 TYR A O   1 
ATOM   823  C CB  . TYR A 1 131 ? 152.317 144.070 150.212 1.00 33.60  ? 131 TYR A CB  1 
ATOM   824  C CG  . TYR A 1 131 ? 151.359 142.981 149.807 1.00 33.60  ? 131 TYR A CG  1 
ATOM   825  C CD1 . TYR A 1 131 ? 151.487 142.338 148.586 1.00 33.60  ? 131 TYR A CD1 1 
ATOM   826  C CD2 . TYR A 1 131 ? 150.322 142.598 150.643 1.00 33.60  ? 131 TYR A CD2 1 
ATOM   827  C CE1 . TYR A 1 131 ? 150.610 141.341 148.212 1.00 33.60  ? 131 TYR A CE1 1 
ATOM   828  C CE2 . TYR A 1 131 ? 149.442 141.604 150.277 1.00 33.60  ? 131 TYR A CE2 1 
ATOM   829  C CZ  . TYR A 1 131 ? 149.591 140.978 149.062 1.00 33.60  ? 131 TYR A CZ  1 
ATOM   830  O OH  . TYR A 1 131 ? 148.715 139.987 148.694 1.00 33.60  ? 131 TYR A OH  1 
ATOM   831  N N   . GLY A 1 132 ? 150.791 146.749 151.127 1.00 34.51  ? 132 GLY A N   1 
ATOM   832  C CA  . GLY A 1 132 ? 149.631 147.446 151.642 1.00 34.51  ? 132 GLY A CA  1 
ATOM   833  C C   . GLY A 1 132 ? 149.120 148.530 150.718 1.00 34.51  ? 132 GLY A C   1 
ATOM   834  O O   . GLY A 1 132 ? 147.911 148.641 150.506 1.00 34.51  ? 132 GLY A O   1 
ATOM   835  N N   . ILE A 1 133 ? 150.024 149.348 150.171 1.00 35.53  ? 133 ILE A N   1 
ATOM   836  C CA  . ILE A 1 133 ? 149.588 150.366 149.213 1.00 35.53  ? 133 ILE A CA  1 
ATOM   837  C C   . ILE A 1 133 ? 149.092 149.714 147.928 1.00 35.53  ? 133 ILE A C   1 
ATOM   838  O O   . ILE A 1 133 ? 148.251 150.281 147.219 1.00 35.53  ? 133 ILE A O   1 
ATOM   839  C CB  . ILE A 1 133 ? 150.698 151.410 148.942 1.00 35.53  ? 133 ILE A CB  1 
ATOM   840  C CG1 . ILE A 1 133 ? 150.155 152.585 148.124 1.00 35.53  ? 133 ILE A CG1 1 
ATOM   841  C CG2 . ILE A 1 133 ? 151.850 150.819 148.188 1.00 35.53  ? 133 ILE A CG2 1 
ATOM   842  C CD1 . ILE A 1 133 ? 149.033 153.338 148.779 1.00 35.53  ? 133 ILE A CD1 1 
ATOM   843  N N   . ALA A 1 134 ? 149.582 148.514 147.611 1.00 33.23  ? 134 ALA A N   1 
ATOM   844  C CA  . ALA A 1 134 ? 149.047 147.780 146.468 1.00 33.23  ? 134 ALA A CA  1 
ATOM   845  C C   . ALA A 1 134 ? 147.622 147.308 146.734 1.00 33.23  ? 134 ALA A C   1 
ATOM   846  O O   . ALA A 1 134 ? 146.735 147.471 145.889 1.00 33.23  ? 134 ALA A O   1 
ATOM   847  C CB  . ALA A 1 134 ? 149.950 146.593 146.139 1.00 33.23  ? 134 ALA A CB  1 
ATOM   848  N N   . THR A 1 135 ? 147.387 146.722 147.908 1.00 34.68  ? 135 THR A N   1 
ATOM   849  C CA  . THR A 1 135 ? 146.088 146.132 148.215 1.00 34.68  ? 135 THR A CA  1 
ATOM   850  C C   . THR A 1 135 ? 145.030 147.188 148.520 1.00 34.68  ? 135 THR A C   1 
ATOM   851  O O   . THR A 1 135 ? 143.845 146.967 148.248 1.00 34.68  ? 135 THR A O   1 
ATOM   852  C CB  . THR A 1 135 ? 146.228 145.155 149.386 1.00 34.68  ? 135 THR A CB  1 
ATOM   853  O OG1 . THR A 1 135 ? 147.254 144.201 149.090 1.00 34.68  ? 135 THR A OG1 1 
ATOM   854  C CG2 . THR A 1 135 ? 144.934 144.400 149.617 1.00 34.68  ? 135 THR A CG2 1 
ATOM   855  N N   . ALA A 1 136 ? 145.431 148.345 149.055 1.00 39.46  ? 136 ALA A N   1 
ATOM   856  C CA  . ALA A 1 136 ? 144.473 149.396 149.381 1.00 39.46  ? 136 ALA A CA  1 
ATOM   857  C C   . ALA A 1 136 ? 143.780 149.960 148.151 1.00 39.46  ? 136 ALA A C   1 
ATOM   858  O O   . ALA A 1 136 ? 142.719 150.579 148.281 1.00 39.46  ? 136 ALA A O   1 
ATOM   859  C CB  . ALA A 1 136 ? 145.169 150.524 150.143 1.00 39.46  ? 136 ALA A CB  1 
ATOM   860  N N   . THR A 1 137 ? 144.351 149.757 146.969 1.00 39.94  ? 137 THR A N   1 
ATOM   861  C CA  . THR A 1 137 ? 143.814 150.284 145.725 1.00 39.94  ? 137 THR A CA  1 
ATOM   862  C C   . THR A 1 137 ? 142.928 149.289 144.986 1.00 39.94  ? 137 THR A C   1 
ATOM   863  O O   . THR A 1 137 ? 142.552 149.549 143.839 1.00 39.94  ? 137 THR A O   1 
ATOM   864  C CB  . THR A 1 137 ? 144.960 150.730 144.821 1.00 39.94  ? 137 THR A CB  1 
ATOM   865  O OG1 . THR A 1 137 ? 145.838 149.623 144.611 1.00 39.94  ? 137 THR A OG1 1 
ATOM   866  C CG2 . THR A 1 137 ? 145.738 151.858 145.463 1.00 39.94  ? 137 THR A CG2 1 
ATOM   867  N N   . GLU A 1 138 ? 142.589 148.156 145.605 1.00 44.07  ? 138 GLU A N   1 
ATOM   868  C CA  . GLU A 1 138 ? 141.635 147.244 144.984 1.00 44.07  ? 138 GLU A CA  1 
ATOM   869  C C   . GLU A 1 138 ? 140.259 147.887 144.866 1.00 44.07  ? 138 GLU A C   1 
ATOM   870  O O   . GLU A 1 138 ? 139.556 147.686 143.868 1.00 44.07  ? 138 GLU A O   1 
ATOM   871  C CB  . GLU A 1 138 ? 141.558 145.942 145.778 1.00 44.07  ? 138 GLU A CB  1 
ATOM   872  C CG  . GLU A 1 138 ? 142.698 144.980 145.495 1.00 44.07  ? 138 GLU A CG  1 
ATOM   873  C CD  . GLU A 1 138 ? 142.561 144.293 144.151 1.00 44.07  ? 138 GLU A CD  1 
ATOM   874  O OE1 . GLU A 1 138 ? 141.550 143.588 143.946 1.00 44.07  ? 138 GLU A OE1 1 
ATOM   875  O OE2 . GLU A 1 138 ? 143.460 144.457 143.300 1.00 44.07  ? 138 GLU A OE2 1 
ATOM   876  N N   . ILE A 1 139 ? 139.858 148.666 145.873 1.00 47.55  ? 139 ILE A N   1 
ATOM   877  C CA  . ILE A 1 139 ? 138.597 149.397 145.790 1.00 47.55  ? 139 ILE A CA  1 
ATOM   878  C C   . ILE A 1 139 ? 138.639 150.389 144.636 1.00 47.55  ? 139 ILE A C   1 
ATOM   879  O O   . ILE A 1 139 ? 137.652 150.568 143.912 1.00 47.55  ? 139 ILE A O   1 
ATOM   880  C CB  . ILE A 1 139 ? 138.289 150.095 147.129 1.00 47.55  ? 139 ILE A CB  1 
ATOM   881  C CG1 . ILE A 1 139 ? 139.511 150.872 147.628 1.00 47.55  ? 139 ILE A CG1 1 
ATOM   882  C CG2 . ILE A 1 139 ? 137.833 149.079 148.166 1.00 47.55  ? 139 ILE A CG2 1 
ATOM   883  C CD1 . ILE A 1 139 ? 139.202 151.863 148.727 1.00 47.55  ? 139 ILE A CD1 1 
ATOM   884  N N   . ALA A 1 140 ? 139.786 151.040 144.440 1.00 47.96  ? 140 ALA A N   1 
ATOM   885  C CA  . ALA A 1 140 ? 139.949 151.944 143.309 1.00 47.96  ? 140 ALA A CA  1 
ATOM   886  C C   . ALA A 1 140 ? 139.845 151.199 141.986 1.00 47.96  ? 140 ALA A C   1 
ATOM   887  O O   . ALA A 1 140 ? 139.223 151.686 141.037 1.00 47.96  ? 140 ALA A O   1 
ATOM   888  C CB  . ALA A 1 140 ? 141.292 152.658 143.414 1.00 47.96  ? 140 ALA A CB  1 
ATOM   889  N N   . TYR A 1 141 ? 140.457 150.017 141.905 1.00 46.48  ? 141 TYR A N   1 
ATOM   890  C CA  . TYR A 1 141 ? 140.392 149.224 140.681 1.00 46.48  ? 141 TYR A CA  1 
ATOM   891  C C   . TYR A 1 141 ? 138.960 148.811 140.364 1.00 46.48  ? 141 TYR A C   1 
ATOM   892  O O   . TYR A 1 141 ? 138.534 148.865 139.205 1.00 46.48  ? 141 TYR A O   1 
ATOM   893  C CB  . TYR A 1 141 ? 141.294 147.997 140.808 1.00 46.48  ? 141 TYR A CB  1 
ATOM   894  C CG  . TYR A 1 141 ? 140.894 146.824 139.942 1.00 46.48  ? 141 TYR A CG  1 
ATOM   895  C CD1 . TYR A 1 141 ? 141.008 146.880 138.560 1.00 46.48  ? 141 TYR A CD1 1 
ATOM   896  C CD2 . TYR A 1 141 ? 140.416 145.653 140.510 1.00 46.48  ? 141 TYR A CD2 1 
ATOM   897  C CE1 . TYR A 1 141 ? 140.646 145.806 137.769 1.00 46.48  ? 141 TYR A CE1 1 
ATOM   898  C CE2 . TYR A 1 141 ? 140.054 144.575 139.728 1.00 46.48  ? 141 TYR A CE2 1 
ATOM   899  C CZ  . TYR A 1 141 ? 140.171 144.656 138.360 1.00 46.48  ? 141 TYR A CZ  1 
ATOM   900  O OH  . TYR A 1 141 ? 139.810 143.581 137.582 1.00 46.48  ? 141 TYR A OH  1 
ATOM   901  N N   . TYR A 1 142 ? 138.202 148.398 141.379 1.00 48.15  ? 142 TYR A N   1 
ATOM   902  C CA  . TYR A 1 142 ? 136.824 147.978 141.145 1.00 48.15  ? 142 TYR A CA  1 
ATOM   903  C C   . TYR A 1 142 ? 135.869 149.150 140.942 1.00 48.15  ? 142 TYR A C   1 
ATOM   904  O O   . TYR A 1 142 ? 134.794 148.957 140.366 1.00 48.15  ? 142 TYR A O   1 
ATOM   905  C CB  . TYR A 1 142 ? 136.334 147.096 142.296 1.00 48.15  ? 142 TYR A CB  1 
ATOM   906  C CG  . TYR A 1 142 ? 136.879 145.686 142.239 1.00 48.15  ? 142 TYR A CG  1 
ATOM   907  C CD1 . TYR A 1 142 ? 136.386 144.765 141.326 1.00 48.15  ? 142 TYR A CD1 1 
ATOM   908  C CD2 . TYR A 1 142 ? 137.887 145.277 143.098 1.00 48.15  ? 142 TYR A CD2 1 
ATOM   909  C CE1 . TYR A 1 142 ? 136.885 143.480 141.270 1.00 48.15  ? 142 TYR A CE1 1 
ATOM   910  C CE2 . TYR A 1 142 ? 138.392 143.997 143.050 1.00 48.15  ? 142 TYR A CE2 1 
ATOM   911  C CZ  . TYR A 1 142 ? 137.888 143.102 142.136 1.00 48.15  ? 142 TYR A CZ  1 
ATOM   912  O OH  . TYR A 1 142 ? 138.394 141.824 142.092 1.00 48.15  ? 142 TYR A OH  1 
ATOM   913  N N   . SER A 1 143 ? 136.226 150.349 141.400 1.00 50.57  ? 143 SER A N   1 
ATOM   914  C CA  . SER A 1 143 ? 135.441 151.540 141.105 1.00 50.57  ? 143 SER A CA  1 
ATOM   915  C C   . SER A 1 143 ? 135.854 152.210 139.803 1.00 50.57  ? 143 SER A C   1 
ATOM   916  O O   . SER A 1 143 ? 135.148 153.109 139.333 1.00 50.57  ? 143 SER A O   1 
ATOM   917  C CB  . SER A 1 143 ? 135.552 152.545 142.255 1.00 50.57  ? 143 SER A CB  1 
ATOM   918  O OG  . SER A 1 143 ? 136.898 152.937 142.463 1.00 50.57  ? 143 SER A OG  1 
ATOM   919  N N   . TYR A 1 144 ? 136.989 151.806 139.228 1.00 50.54  ? 144 TYR A N   1 
ATOM   920  C CA  . TYR A 1 144 ? 137.374 152.282 137.904 1.00 50.54  ? 144 TYR A CA  1 
ATOM   921  C C   . TYR A 1 144 ? 136.340 151.884 136.861 1.00 50.54  ? 144 TYR A C   1 
ATOM   922  O O   . TYR A 1 144 ? 136.108 152.615 135.891 1.00 50.54  ? 144 TYR A O   1 
ATOM   923  C CB  . TYR A 1 144 ? 138.752 151.722 137.547 1.00 50.54  ? 144 TYR A CB  1 
ATOM   924  C CG  . TYR A 1 144 ? 139.163 151.873 136.100 1.00 50.54  ? 144 TYR A CG  1 
ATOM   925  C CD1 . TYR A 1 144 ? 139.107 153.102 135.460 1.00 50.54  ? 144 TYR A CD1 1 
ATOM   926  C CD2 . TYR A 1 144 ? 139.612 150.779 135.373 1.00 50.54  ? 144 TYR A CD2 1 
ATOM   927  C CE1 . TYR A 1 144 ? 139.485 153.234 134.139 1.00 50.54  ? 144 TYR A CE1 1 
ATOM   928  C CE2 . TYR A 1 144 ? 139.991 150.903 134.052 1.00 50.54  ? 144 TYR A CE2 1 
ATOM   929  C CZ  . TYR A 1 144 ? 139.924 152.133 133.440 1.00 50.54  ? 144 TYR A CZ  1 
ATOM   930  O OH  . TYR A 1 144 ? 140.298 152.265 132.124 1.00 50.54  ? 144 TYR A OH  1 
ATOM   931  N N   . ILE A 1 145 ? 135.702 150.729 137.052 1.00 51.97  ? 145 ILE A N   1 
ATOM   932  C CA  . ILE A 1 145 ? 134.729 150.230 136.089 1.00 51.97  ? 145 ILE A CA  1 
ATOM   933  C C   . ILE A 1 145 ? 133.489 151.117 136.051 1.00 51.97  ? 145 ILE A C   1 
ATOM   934  O O   . ILE A 1 145 ? 132.901 151.325 134.984 1.00 51.97  ? 145 ILE A O   1 
ATOM   935  C CB  . ILE A 1 145 ? 134.376 148.773 136.430 1.00 51.97  ? 145 ILE A CB  1 
ATOM   936  C CG1 . ILE A 1 145 ? 135.639 147.915 136.441 1.00 51.97  ? 145 ILE A CG1 1 
ATOM   937  C CG2 . ILE A 1 145 ? 133.412 148.216 135.418 1.00 51.97  ? 145 ILE A CG2 1 
ATOM   938  C CD1 . ILE A 1 145 ? 135.436 146.550 137.042 1.00 51.97  ? 145 ILE A CD1 1 
ATOM   939  N N   . TYR A 1 146 ? 133.084 151.665 137.200 1.00 57.73  ? 146 TYR A N   1 
ATOM   940  C CA  . TYR A 1 146 ? 131.824 152.399 137.291 1.00 57.73  ? 146 TYR A CA  1 
ATOM   941  C C   . TYR A 1 146 ? 131.807 153.643 136.410 1.00 57.73  ? 146 TYR A C   1 
ATOM   942  O O   . TYR A 1 146 ? 130.732 154.090 135.994 1.00 57.73  ? 146 TYR A O   1 
ATOM   943  C CB  . TYR A 1 146 ? 131.554 152.786 138.747 1.00 57.73  ? 146 TYR A CB  1 
ATOM   944  C CG  . TYR A 1 146 ? 130.274 153.564 138.959 1.00 57.73  ? 146 TYR A CG  1 
ATOM   945  C CD1 . TYR A 1 146 ? 129.064 153.106 138.453 1.00 57.73  ? 146 TYR A CD1 1 
ATOM   946  C CD2 . TYR A 1 146 ? 130.277 154.762 139.663 1.00 57.73  ? 146 TYR A CD2 1 
ATOM   947  C CE1 . TYR A 1 146 ? 127.893 153.817 138.646 1.00 57.73  ? 146 TYR A CE1 1 
ATOM   948  C CE2 . TYR A 1 146 ? 129.110 155.480 139.859 1.00 57.73  ? 146 TYR A CE2 1 
ATOM   949  C CZ  . TYR A 1 146 ? 127.922 155.003 139.349 1.00 57.73  ? 146 TYR A CZ  1 
ATOM   950  O OH  . TYR A 1 146 ? 126.760 155.713 139.543 1.00 57.73  ? 146 TYR A OH  1 
ATOM   951  N N   . SER A 1 147 ? 132.972 154.218 136.114 1.00 56.49  ? 147 SER A N   1 
ATOM   952  C CA  . SER A 1 147 ? 133.044 155.460 135.358 1.00 56.49  ? 147 SER A CA  1 
ATOM   953  C C   . SER A 1 147 ? 133.531 155.258 133.926 1.00 56.49  ? 147 SER A C   1 
ATOM   954  O O   . SER A 1 147 ? 133.949 156.226 133.282 1.00 56.49  ? 147 SER A O   1 
ATOM   955  C CB  . SER A 1 147 ? 133.941 156.464 136.083 1.00 56.49  ? 147 SER A CB  1 
ATOM   956  O OG  . SER A 1 147 ? 133.267 157.040 137.187 1.00 56.49  ? 147 SER A OG  1 
ATOM   957  N N   . VAL A 1 148 ? 133.493 154.028 133.414 1.00 55.15  ? 148 VAL A N   1 
ATOM   958  C CA  . VAL A 1 148 ? 133.918 153.769 132.041 1.00 55.15  ? 148 VAL A CA  1 
ATOM   959  C C   . VAL A 1 148 ? 132.886 152.923 131.305 1.00 55.15  ? 148 VAL A C   1 
ATOM   960  O O   . VAL A 1 148 ? 132.929 152.814 130.075 1.00 55.15  ? 148 VAL A O   1 
ATOM   961  C CB  . VAL A 1 148 ? 135.299 153.090 131.999 1.00 55.15  ? 148 VAL A CB  1 
ATOM   962  C CG1 . VAL A 1 148 ? 136.360 153.990 132.609 1.00 55.15  ? 148 VAL A CG1 1 
ATOM   963  C CG2 . VAL A 1 148 ? 135.256 151.752 132.712 1.00 55.15  ? 148 VAL A CG2 1 
ATOM   964  N N   . VAL A 1 149 ? 131.952 152.321 132.039 1.00 57.46  ? 149 VAL A N   1 
ATOM   965  C CA  . VAL A 1 149 ? 130.959 151.433 131.450 1.00 57.46  ? 149 VAL A CA  1 
ATOM   966  C C   . VAL A 1 149 ? 129.571 152.031 131.648 1.00 57.46  ? 149 VAL A C   1 
ATOM   967  O O   . VAL A 1 149 ? 129.387 153.029 132.345 1.00 57.46  ? 149 VAL A O   1 
ATOM   968  C CB  . VAL A 1 149 ? 131.018 150.008 132.033 1.00 57.46  ? 149 VAL A CB  1 
ATOM   969  C CG1 . VAL A 1 149 ? 132.437 149.457 131.972 1.00 57.46  ? 149 VAL A CG1 1 
ATOM   970  C CG2 . VAL A 1 149 ? 130.470 149.988 133.450 1.00 57.46  ? 149 VAL A CG2 1 
ATOM   971  N N   . ASP A 1 150 ? 128.588 151.396 131.015 1.00 61.07  ? 150 ASP A N   1 
ATOM   972  C CA  . ASP A 1 150 ? 127.202 151.807 131.161 1.00 61.07  ? 150 ASP A CA  1 
ATOM   973  C C   . ASP A 1 150 ? 126.669 151.412 132.536 1.00 61.07  ? 150 ASP A C   1 
ATOM   974  O O   . ASP A 1 150 ? 127.175 150.496 133.191 1.00 61.07  ? 150 ASP A O   1 
ATOM   975  C CB  . ASP A 1 150 ? 126.340 151.184 130.063 1.00 61.07  ? 150 ASP A CB  1 
ATOM   976  N N   . LEU A 1 151 ? 125.632 152.129 132.973 1.00 63.48  ? 151 LEU A N   1 
ATOM   977  C CA  . LEU A 1 151 ? 125.037 151.854 134.277 1.00 63.48  ? 151 LEU A CA  1 
ATOM   978  C C   . LEU A 1 151 ? 124.380 150.478 134.315 1.00 63.48  ? 151 LEU A C   1 
ATOM   979  O O   . LEU A 1 151 ? 124.490 149.761 135.316 1.00 63.48  ? 151 LEU A O   1 
ATOM   980  C CB  . LEU A 1 151 ? 124.023 152.942 134.629 1.00 63.48  ? 151 LEU A CB  1 
ATOM   981  N N   . GLY A 1 152 ? 123.690 150.096 133.238 1.00 63.31  ? 152 GLY A N   1 
ATOM   982  C CA  . GLY A 1 152 ? 122.971 148.834 133.235 1.00 63.31  ? 152 GLY A CA  1 
ATOM   983  C C   . GLY A 1 152 ? 123.870 147.615 133.272 1.00 63.31  ? 152 GLY A C   1 
ATOM   984  O O   . GLY A 1 152 ? 123.534 146.613 133.910 1.00 63.31  ? 152 GLY A O   1 
ATOM   985  N N   . MET A 1 153 ? 125.014 147.677 132.599 1.00 61.13  ? 153 MET A N   1 
ATOM   986  C CA  . MET A 1 153 ? 125.924 146.544 132.503 1.00 61.13  ? 153 MET A CA  1 
ATOM   987  C C   . MET A 1 153 ? 126.989 146.540 133.590 1.00 61.13  ? 153 MET A C   1 
ATOM   988  O O   . MET A 1 153 ? 127.883 145.684 133.555 1.00 61.13  ? 153 MET A O   1 
ATOM   989  C CB  . MET A 1 153 ? 126.597 146.529 131.127 1.00 61.13  ? 153 MET A CB  1 
ATOM   990  N N   . TYR A 1 154 ? 126.921 147.480 134.538 1.00 57.35  ? 154 TYR A N   1 
ATOM   991  C CA  . TYR A 1 154 ? 127.968 147.603 135.548 1.00 57.35  ? 154 TYR A CA  1 
ATOM   992  C C   . TYR A 1 154 ? 128.059 146.352 136.410 1.00 57.35  ? 154 TYR A C   1 
ATOM   993  O O   . TYR A 1 154 ? 129.159 145.872 136.703 1.00 57.35  ? 154 TYR A O   1 
ATOM   994  C CB  . TYR A 1 154 ? 127.716 148.835 136.417 1.00 57.35  ? 154 TYR A CB  1 
ATOM   995  N N   . GLN A 1 155 ? 126.913 145.807 136.822 1.00 57.42  ? 155 GLN A N   1 
ATOM   996  C CA  . GLN A 1 155 ? 126.922 144.618 137.667 1.00 57.42  ? 155 GLN A CA  1 
ATOM   997  C C   . GLN A 1 155 ? 127.543 143.431 136.939 1.00 57.42  ? 155 GLN A C   1 
ATOM   998  O O   . GLN A 1 155 ? 128.374 142.707 137.502 1.00 57.42  ? 155 GLN A O   1 
ATOM   999  C CB  . GLN A 1 155 ? 125.501 144.290 138.123 1.00 57.42  ? 155 GLN A CB  1 
ATOM   1000 N N   . LYS A 1 156 ? 127.164 143.227 135.674 1.00 55.89  ? 156 LYS A N   1 
ATOM   1001 C CA  . LYS A 1 156 ? 127.672 142.069 134.947 1.00 55.89  ? 156 LYS A CA  1 
ATOM   1002 C C   . LYS A 1 156 ? 129.160 142.210 134.649 1.00 55.89  ? 156 LYS A C   1 
ATOM   1003 O O   . LYS A 1 156 ? 129.908 141.230 134.747 1.00 55.89  ? 156 LYS A O   1 
ATOM   1004 C CB  . LYS A 1 156 ? 126.861 141.834 133.667 1.00 55.89  ? 156 LYS A CB  1 
ATOM   1005 C CG  . LYS A 1 156 ? 127.206 142.703 132.469 1.00 55.89  ? 156 LYS A CG  1 
ATOM   1006 C CD  . LYS A 1 156 ? 126.412 142.269 131.247 1.00 55.89  ? 156 LYS A CD  1 
ATOM   1007 C CE  . LYS A 1 156 ? 126.743 143.115 130.030 1.00 55.89  ? 156 LYS A CE  1 
ATOM   1008 N NZ  . LYS A 1 156 ? 128.128 142.876 129.544 1.00 55.89  ? 156 LYS A NZ  1 
ATOM   1009 N N   . VAL A 1 157 ? 129.625 143.420 134.322 1.00 54.01  ? 157 VAL A N   1 
ATOM   1010 C CA  . VAL A 1 157 ? 131.051 143.575 134.046 1.00 54.01  ? 157 VAL A CA  1 
ATOM   1011 C C   . VAL A 1 157 ? 131.862 143.469 135.334 1.00 54.01  ? 157 VAL A C   1 
ATOM   1012 O O   . VAL A 1 157 ? 132.979 142.939 135.332 1.00 54.01  ? 157 VAL A O   1 
ATOM   1013 C CB  . VAL A 1 157 ? 131.330 144.886 133.287 1.00 54.01  ? 157 VAL A CB  1 
ATOM   1014 C CG1 . VAL A 1 157 ? 130.621 144.877 131.941 1.00 54.01  ? 157 VAL A CG1 1 
ATOM   1015 C CG2 . VAL A 1 157 ? 130.924 146.091 134.096 1.00 54.01  ? 157 VAL A CG2 1 
ATOM   1016 N N   . THR A 1 158 ? 131.316 143.951 136.456 1.00 51.49  ? 158 THR A N   1 
ATOM   1017 C CA  . THR A 1 158 ? 132.000 143.793 137.734 1.00 51.49  ? 158 THR A CA  1 
ATOM   1018 C C   . THR A 1 158 ? 132.111 142.325 138.116 1.00 51.49  ? 158 THR A C   1 
ATOM   1019 O O   . THR A 1 158 ? 133.154 141.881 138.611 1.00 51.49  ? 158 THR A O   1 
ATOM   1020 C CB  . THR A 1 158 ? 131.268 144.572 138.827 1.00 51.49  ? 158 THR A CB  1 
ATOM   1021 O OG1 . THR A 1 158 ? 130.861 145.848 138.319 1.00 51.49  ? 158 THR A OG1 1 
ATOM   1022 C CG2 . THR A 1 158 ? 132.173 144.777 140.030 1.00 51.49  ? 158 THR A CG2 1 
ATOM   1023 N N   . SER A 1 159 ? 131.044 141.554 137.891 1.00 50.22  ? 159 SER A N   1 
ATOM   1024 C CA  . SER A 1 159 ? 131.105 140.120 138.149 1.00 50.22  ? 159 SER A CA  1 
ATOM   1025 C C   . SER A 1 159 ? 132.110 139.441 137.229 1.00 50.22  ? 159 SER A C   1 
ATOM   1026 O O   . SER A 1 159 ? 132.840 138.536 137.653 1.00 50.22  ? 159 SER A O   1 
ATOM   1027 C CB  . SER A 1 159 ? 129.721 139.496 137.981 1.00 50.22  ? 159 SER A CB  1 
ATOM   1028 O OG  . SER A 1 159 ? 129.179 139.812 136.712 1.00 50.22  ? 159 SER A OG  1 
ATOM   1029 N N   . TYR A 1 160 ? 132.165 139.868 135.965 1.00 47.93  ? 160 TYR A N   1 
ATOM   1030 C CA  . TYR A 1 160 ? 133.134 139.303 135.032 1.00 47.93  ? 160 TYR A CA  1 
ATOM   1031 C C   . TYR A 1 160 ? 134.562 139.579 135.486 1.00 47.93  ? 160 TYR A C   1 
ATOM   1032 O O   . TYR A 1 160 ? 135.423 138.698 135.419 1.00 47.93  ? 160 TYR A O   1 
ATOM   1033 C CB  . TYR A 1 160 ? 132.896 139.860 133.629 1.00 47.93  ? 160 TYR A CB  1 
ATOM   1034 N N   . CYS A 1 161 ? 134.827 140.793 135.969 1.00 46.62  ? 161 CYS A N   1 
ATOM   1035 C CA  . CYS A 1 161 ? 136.174 141.127 136.425 1.00 46.62  ? 161 CYS A CA  1 
ATOM   1036 C C   . CYS A 1 161 ? 136.525 140.399 137.720 1.00 46.62  ? 161 CYS A C   1 
ATOM   1037 O O   . CYS A 1 161 ? 137.676 139.985 137.912 1.00 46.62  ? 161 CYS A O   1 
ATOM   1038 C CB  . CYS A 1 161 ? 136.304 142.638 136.596 1.00 46.62  ? 161 CYS A CB  1 
ATOM   1039 S SG  . CYS A 1 161 ? 136.041 143.552 135.064 1.00 46.62  ? 161 CYS A SG  1 
ATOM   1040 N N   . ARG A 1 162 ? 135.553 140.238 138.622 1.00 43.62  ? 162 ARG A N   1 
ATOM   1041 C CA  . ARG A 1 162 ? 135.794 139.457 139.832 1.00 43.62  ? 162 ARG A CA  1 
ATOM   1042 C C   . ARG A 1 162 ? 136.120 138.009 139.491 1.00 43.62  ? 162 ARG A C   1 
ATOM   1043 O O   . ARG A 1 162 ? 137.047 137.416 140.061 1.00 43.62  ? 162 ARG A O   1 
ATOM   1044 C CB  . ARG A 1 162 ? 134.576 139.530 140.750 1.00 43.62  ? 162 ARG A CB  1 
ATOM   1045 C CG  . ARG A 1 162 ? 134.824 139.044 142.168 1.00 43.62  ? 162 ARG A CG  1 
ATOM   1046 C CD  . ARG A 1 162 ? 136.044 139.710 142.779 1.00 43.62  ? 162 ARG A CD  1 
ATOM   1047 N NE  . ARG A 1 162 ? 135.943 139.842 144.228 1.00 43.62  ? 162 ARG A NE  1 
ATOM   1048 C CZ  . ARG A 1 162 ? 135.117 140.669 144.856 1.00 43.62  ? 162 ARG A CZ  1 
ATOM   1049 N NH1 . ARG A 1 162 ? 134.312 141.483 144.192 1.00 43.62  ? 162 ARG A NH1 1 
ATOM   1050 N NH2 . ARG A 1 162 ? 135.105 140.687 146.186 1.00 43.62  ? 162 ARG A NH2 1 
ATOM   1051 N N   . SER A 1 163 ? 135.375 137.427 138.549 1.00 40.41  ? 163 SER A N   1 
ATOM   1052 C CA  . SER A 1 163 ? 135.692 136.083 138.087 1.00 40.41  ? 163 SER A CA  1 
ATOM   1053 C C   . SER A 1 163 ? 137.053 136.036 137.410 1.00 40.41  ? 163 SER A C   1 
ATOM   1054 O O   . SER A 1 163 ? 137.760 135.034 137.522 1.00 40.41  ? 163 SER A O   1 
ATOM   1055 C CB  . SER A 1 163 ? 134.609 135.582 137.135 1.00 40.41  ? 163 SER A CB  1 
ATOM   1056 O OG  . SER A 1 163 ? 134.303 136.560 136.160 1.00 40.41  ? 163 SER A OG  1 
ATOM   1057 N N   . ALA A 1 164 ? 137.432 137.101 136.702 1.00 39.63  ? 164 ALA A N   1 
ATOM   1058 C CA  . ALA A 1 164 ? 138.756 137.151 136.090 1.00 39.63  ? 164 ALA A CA  1 
ATOM   1059 C C   . ALA A 1 164 ? 139.852 137.125 137.146 1.00 39.63  ? 164 ALA A C   1 
ATOM   1060 O O   . ALA A 1 164 ? 140.856 136.420 136.992 1.00 39.63  ? 164 ALA A O   1 
ATOM   1061 C CB  . ALA A 1 164 ? 138.882 138.396 135.215 1.00 39.63  ? 164 ALA A CB  1 
ATOM   1062 N N   . THR A 1 165 ? 139.676 137.886 138.228 1.00 38.28  ? 165 THR A N   1 
ATOM   1063 C CA  . THR A 1 165 ? 140.645 137.848 139.321 1.00 38.28  ? 165 THR A CA  1 
ATOM   1064 C C   . THR A 1 165 ? 140.711 136.462 139.950 1.00 38.28  ? 165 THR A C   1 
ATOM   1065 O O   . THR A 1 165 ? 141.800 135.963 140.265 1.00 38.28  ? 165 THR A O   1 
ATOM   1066 C CB  . THR A 1 165 ? 140.296 138.888 140.384 1.00 38.28  ? 165 THR A CB  1 
ATOM   1067 O OG1 . THR A 1 165 ? 139.005 138.597 140.931 1.00 38.28  ? 165 THR A OG1 1 
ATOM   1068 C CG2 . THR A 1 165 ? 140.291 140.285 139.790 1.00 38.28  ? 165 THR A CG2 1 
ATOM   1069 N N   . LEU A 1 166 ? 139.552 135.827 140.147 1.00 40.21  ? 166 LEU A N   1 
ATOM   1070 C CA  . LEU A 1 166 ? 139.533 134.488 140.731 1.00 40.21  ? 166 LEU A CA  1 
ATOM   1071 C C   . LEU A 1 166 ? 140.226 133.474 139.824 1.00 40.21  ? 166 LEU A C   1 
ATOM   1072 O O   . LEU A 1 166 ? 140.990 132.624 140.300 1.00 40.21  ? 166 LEU A O   1 
ATOM   1073 C CB  . LEU A 1 166 ? 138.094 134.066 141.019 1.00 40.21  ? 166 LEU A CB  1 
ATOM   1074 C CG  . LEU A 1 166 ? 137.387 134.894 142.097 1.00 40.21  ? 166 LEU A CG  1 
ATOM   1075 C CD1 . LEU A 1 166 ? 135.922 134.500 142.222 1.00 40.21  ? 166 LEU A CD1 1 
ATOM   1076 C CD2 . LEU A 1 166 ? 138.096 134.764 143.436 1.00 40.21  ? 166 LEU A CD2 1 
ATOM   1077 N N   . VAL A 1 167 ? 139.980 133.555 138.513 1.00 37.68  ? 167 VAL A N   1 
ATOM   1078 C CA  . VAL A 1 167 ? 140.650 132.674 137.558 1.00 37.68  ? 167 VAL A CA  1 
ATOM   1079 C C   . VAL A 1 167 ? 142.151 132.919 137.563 1.00 37.68  ? 167 VAL A C   1 
ATOM   1080 O O   . VAL A 1 167 ? 142.945 131.974 137.509 1.00 37.68  ? 167 VAL A O   1 
ATOM   1081 C CB  . VAL A 1 167 ? 140.056 132.847 136.147 1.00 37.68  ? 167 VAL A CB  1 
ATOM   1082 C CG1 . VAL A 1 167 ? 140.832 132.016 135.145 1.00 37.68  ? 167 VAL A CG1 1 
ATOM   1083 C CG2 . VAL A 1 167 ? 138.606 132.410 136.129 1.00 37.68  ? 167 VAL A CG2 1 
ATOM   1084 N N   . GLY A 1 168 ? 142.565 134.182 137.614 1.00 34.38  ? 168 GLY A N   1 
ATOM   1085 C CA  . GLY A 1 168 ? 143.975 134.505 137.656 1.00 34.38  ? 168 GLY A CA  1 
ATOM   1086 C C   . GLY A 1 168 ? 144.665 133.927 138.870 1.00 34.38  ? 168 GLY A C   1 
ATOM   1087 O O   . GLY A 1 168 ? 145.743 133.331 138.761 1.00 34.38  ? 168 GLY A O   1 
ATOM   1088 N N   . PHE A 1 169 ? 144.041 134.083 140.039 1.00 35.05  ? 169 PHE A N   1 
ATOM   1089 C CA  . PHE A 1 169 ? 144.649 133.551 141.252 1.00 35.05  ? 169 PHE A CA  1 
ATOM   1090 C C   . PHE A 1 169 ? 144.663 132.029 141.245 1.00 35.05  ? 169 PHE A C   1 
ATOM   1091 O O   . PHE A 1 169 ? 145.644 131.422 141.685 1.00 35.05  ? 169 PHE A O   1 
ATOM   1092 C CB  . PHE A 1 169 ? 143.928 134.078 142.490 1.00 35.05  ? 169 PHE A CB  1 
ATOM   1093 C CG  . PHE A 1 169 ? 144.795 134.116 143.714 1.00 35.05  ? 169 PHE A CG  1 
ATOM   1094 C CD1 . PHE A 1 169 ? 145.272 135.322 144.197 1.00 35.05  ? 169 PHE A CD1 1 
ATOM   1095 C CD2 . PHE A 1 169 ? 145.141 132.951 144.379 1.00 35.05  ? 169 PHE A CD2 1 
ATOM   1096 C CE1 . PHE A 1 169 ? 146.077 135.366 145.316 1.00 35.05  ? 169 PHE A CE1 1 
ATOM   1097 C CE2 . PHE A 1 169 ? 145.945 132.990 145.503 1.00 35.05  ? 169 PHE A CE2 1 
ATOM   1098 C CZ  . PHE A 1 169 ? 146.413 134.200 145.971 1.00 35.05  ? 169 PHE A CZ  1 
ATOM   1099 N N   . THR A 1 170 ? 143.603 131.394 140.735 1.00 39.68  ? 170 THR A N   1 
ATOM   1100 C CA  . THR A 1 170 ? 143.597 129.937 140.635 1.00 39.68  ? 170 THR A CA  1 
ATOM   1101 C C   . THR A 1 170 ? 144.671 129.432 139.679 1.00 39.68  ? 170 THR A C   1 
ATOM   1102 O O   . THR A 1 170 ? 145.344 128.435 139.973 1.00 39.68  ? 170 THR A O   1 
ATOM   1103 C CB  . THR A 1 170 ? 142.224 129.448 140.181 1.00 39.68  ? 170 THR A CB  1 
ATOM   1104 O OG1 . THR A 1 170 ? 141.205 130.124 140.927 1.00 39.68  ? 170 THR A OG1 1 
ATOM   1105 C CG2 . THR A 1 170 ? 142.096 127.950 140.403 1.00 39.68  ? 170 THR A CG2 1 
ATOM   1106 N N   . VAL A 1 171 ? 144.846 130.104 138.540 1.00 38.45  ? 171 VAL A N   1 
ATOM   1107 C CA  . VAL A 1 171 ? 145.867 129.721 137.573 1.00 38.45  ? 171 VAL A CA  1 
ATOM   1108 C C   . VAL A 1 171 ? 147.259 129.883 138.166 1.00 38.45  ? 171 VAL A C   1 
ATOM   1109 O O   . VAL A 1 171 ? 148.109 128.999 138.025 1.00 38.45  ? 171 VAL A O   1 
ATOM   1110 C CB  . VAL A 1 171 ? 145.700 130.540 136.280 1.00 38.45  ? 171 VAL A CB  1 
ATOM   1111 C CG1 . VAL A 1 171 ? 146.995 130.554 135.480 1.00 38.45  ? 171 VAL A CG1 1 
ATOM   1112 C CG2 . VAL A 1 171 ? 144.557 129.986 135.446 1.00 38.45  ? 171 VAL A CG2 1 
ATOM   1113 N N   . GLY A 1 172 ? 147.513 131.004 138.843 1.00 35.19  ? 172 GLY A N   1 
ATOM   1114 C CA  . GLY A 1 172 ? 148.799 131.179 139.496 1.00 35.19  ? 172 GLY A CA  1 
ATOM   1115 C C   . GLY A 1 172 ? 149.045 130.143 140.575 1.00 35.19  ? 172 GLY A C   1 
ATOM   1116 O O   . GLY A 1 172 ? 150.156 129.623 140.711 1.00 35.19  ? 172 GLY A O   1 
ATOM   1117 N N   . SER A 1 173 ? 148.006 129.813 141.343 1.00 39.90  ? 173 SER A N   1 
ATOM   1118 C CA  . SER A 1 173 ? 148.139 128.828 142.409 1.00 39.90  ? 173 SER A CA  1 
ATOM   1119 C C   . SER A 1 173 ? 148.487 127.452 141.851 1.00 39.90  ? 173 SER A C   1 
ATOM   1120 O O   . SER A 1 173 ? 149.414 126.790 142.335 1.00 39.90  ? 173 SER A O   1 
ATOM   1121 C CB  . SER A 1 173 ? 146.843 128.779 143.216 1.00 39.90  ? 173 SER A CB  1 
ATOM   1122 O OG  . SER A 1 173 ? 146.965 127.931 144.338 1.00 39.90  ? 173 SER A OG  1 
ATOM   1123 N N   . VAL A 1 174 ? 147.761 127.008 140.820 1.00 41.41  ? 174 VAL A N   1 
ATOM   1124 C CA  . VAL A 1 174 ? 148.052 125.692 140.254 1.00 41.41  ? 174 VAL A CA  1 
ATOM   1125 C C   . VAL A 1 174 ? 149.393 125.693 139.529 1.00 41.41  ? 174 VAL A C   1 
ATOM   1126 O O   . VAL A 1 174 ? 150.103 124.681 139.537 1.00 41.41  ? 174 VAL A O   1 
ATOM   1127 C CB  . VAL A 1 174 ? 146.911 125.207 139.337 1.00 41.41  ? 174 VAL A CB  1 
ATOM   1128 C CG1 . VAL A 1 174 ? 145.634 125.013 140.136 1.00 41.41  ? 174 VAL A CG1 1 
ATOM   1129 C CG2 . VAL A 1 174 ? 146.689 126.160 138.180 1.00 41.41  ? 174 VAL A CG2 1 
ATOM   1130 N N   . LEU A 1 175 ? 149.775 126.812 138.904 1.00 40.66  ? 175 LEU A N   1 
ATOM   1131 C CA  . LEU A 1 175 ? 151.085 126.894 138.265 1.00 40.66  ? 175 LEU A CA  1 
ATOM   1132 C C   . LEU A 1 175 ? 152.198 126.754 139.294 1.00 40.66  ? 175 LEU A C   1 
ATOM   1133 O O   . LEU A 1 175 ? 153.155 125.998 139.091 1.00 40.66  ? 175 LEU A O   1 
ATOM   1134 C CB  . LEU A 1 175 ? 151.211 128.218 137.508 1.00 40.66  ? 175 LEU A CB  1 
ATOM   1135 C CG  . LEU A 1 175 ? 152.577 128.674 136.983 1.00 40.66  ? 175 LEU A CG  1 
ATOM   1136 C CD1 . LEU A 1 175 ? 153.302 127.568 136.223 1.00 40.66  ? 175 LEU A CD1 1 
ATOM   1137 C CD2 . LEU A 1 175 ? 152.420 129.912 136.113 1.00 40.66  ? 175 LEU A CD2 1 
ATOM   1138 N N   . GLY A 1 176 ? 152.083 127.473 140.413 1.00 40.81  ? 176 GLY A N   1 
ATOM   1139 C CA  . GLY A 1 176 ? 153.081 127.351 141.462 1.00 40.81  ? 176 GLY A CA  1 
ATOM   1140 C C   . GLY A 1 176 ? 153.131 125.957 142.055 1.00 40.81  ? 176 GLY A C   1 
ATOM   1141 O O   . GLY A 1 176 ? 154.212 125.421 142.316 1.00 40.81  ? 176 GLY A O   1 
ATOM   1142 N N   . GLN A 1 177 ? 151.960 125.348 142.267 1.00 43.39  ? 177 GLN A N   1 
ATOM   1143 C CA  . GLN A 1 177 ? 151.917 123.994 142.809 1.00 43.39  ? 177 GLN A CA  1 
ATOM   1144 C C   . GLN A 1 177 ? 152.572 122.997 141.862 1.00 43.39  ? 177 GLN A C   1 
ATOM   1145 O O   . GLN A 1 177 ? 153.336 122.128 142.297 1.00 43.39  ? 177 GLN A O   1 
ATOM   1146 C CB  . GLN A 1 177 ? 150.472 123.594 143.098 1.00 43.39  ? 177 GLN A CB  1 
ATOM   1147 N N   . ILE A 1 178 ? 152.298 123.115 140.561 1.00 44.59  ? 178 ILE A N   1 
ATOM   1148 C CA  . ILE A 1 178 ? 152.880 122.193 139.593 1.00 44.59  ? 178 ILE A CA  1 
ATOM   1149 C C   . ILE A 1 178 ? 154.383 122.410 139.480 1.00 44.59  ? 178 ILE A C   1 
ATOM   1150 O O   . ILE A 1 178 ? 155.153 121.452 139.341 1.00 44.59  ? 178 ILE A O   1 
ATOM   1151 C CB  . ILE A 1 178 ? 152.182 122.339 138.229 1.00 44.59  ? 178 ILE A CB  1 
ATOM   1152 N N   . LEU A 1 179 ? 154.828 123.668 139.538 1.00 46.62  ? 179 LEU A N   1 
ATOM   1153 C CA  . LEU A 1 179 ? 156.247 123.968 139.401 1.00 46.62  ? 179 LEU A CA  1 
ATOM   1154 C C   . LEU A 1 179 ? 157.054 123.607 140.640 1.00 46.62  ? 179 LEU A C   1 
ATOM   1155 O O   . LEU A 1 179 ? 158.252 123.331 140.520 1.00 46.62  ? 179 LEU A O   1 
ATOM   1156 C CB  . LEU A 1 179 ? 156.441 125.451 139.077 1.00 46.62  ? 179 LEU A CB  1 
ATOM   1157 N N   . VAL A 1 180 ? 156.437 123.599 141.822 1.00 47.54  ? 180 VAL A N   1 
ATOM   1158 C CA  . VAL A 1 180 ? 157.169 123.291 143.044 1.00 47.54  ? 180 VAL A CA  1 
ATOM   1159 C C   . VAL A 1 180 ? 157.003 121.843 143.497 1.00 47.54  ? 180 VAL A C   1 
ATOM   1160 O O   . VAL A 1 180 ? 157.846 121.349 144.261 1.00 47.54  ? 180 VAL A O   1 
ATOM   1161 C CB  . VAL A 1 180 ? 156.757 124.245 144.184 1.00 47.54  ? 180 VAL A CB  1 
ATOM   1162 N N   . SER A 1 181 ? 155.956 121.148 143.049 1.00 49.99  ? 181 SER A N   1 
ATOM   1163 C CA  . SER A 1 181 ? 155.710 119.788 143.520 1.00 49.99  ? 181 SER A CA  1 
ATOM   1164 C C   . SER A 1 181 ? 156.533 118.766 142.742 1.00 49.99  ? 181 SER A C   1 
ATOM   1165 O O   . SER A 1 181 ? 157.370 118.060 143.315 1.00 49.99  ? 181 SER A O   1 
ATOM   1166 C CB  . SER A 1 181 ? 154.217 119.464 143.423 1.00 49.99  ? 181 SER A CB  1 
ATOM   1167 N N   . VAL A 1 182 ? 156.310 118.675 141.432 1.00 51.00  ? 182 VAL A N   1 
ATOM   1168 C CA  . VAL A 1 182 ? 156.977 117.678 140.612 1.00 51.00  ? 182 VAL A CA  1 
ATOM   1169 C C   . VAL A 1 182 ? 158.105 118.268 139.772 1.00 51.00  ? 182 VAL A C   1 
ATOM   1170 O O   . VAL A 1 182 ? 159.099 117.576 139.524 1.00 51.00  ? 182 VAL A O   1 
ATOM   1171 C CB  . VAL A 1 182 ? 155.960 116.943 139.715 1.00 51.00  ? 182 VAL A CB  1 
ATOM   1172 N N   . ALA A 1 183 ? 157.985 119.521 139.328 1.00 51.66  ? 183 ALA A N   1 
ATOM   1173 C CA  . ALA A 1 183 ? 159.048 120.132 138.541 1.00 51.66  ? 183 ALA A CA  1 
ATOM   1174 C C   . ALA A 1 183 ? 160.278 120.450 139.378 1.00 51.66  ? 183 ALA A C   1 
ATOM   1175 O O   . ALA A 1 183 ? 161.384 120.513 138.830 1.00 51.66  ? 183 ALA A O   1 
ATOM   1176 C CB  . ALA A 1 183 ? 158.538 121.404 137.862 1.00 51.66  ? 183 ALA A CB  1 
ATOM   1177 N N   . GLY A 1 184 ? 160.115 120.642 140.682 1.00 52.32  ? 184 GLY A N   1 
ATOM   1178 C CA  . GLY A 1 184 ? 161.236 120.985 141.538 1.00 52.32  ? 184 GLY A CA  1 
ATOM   1179 C C   . GLY A 1 184 ? 161.844 122.336 141.236 1.00 52.32  ? 184 GLY A C   1 
ATOM   1180 O O   . GLY A 1 184 ? 163.072 122.485 141.289 1.00 52.32  ? 184 GLY A O   1 
ATOM   1181 N N   . TRP A 1 185 ? 161.016 123.326 140.918 1.00 50.42  ? 185 TRP A N   1 
ATOM   1182 C CA  . TRP A 1 185 ? 161.492 124.669 140.623 1.00 50.42  ? 185 TRP A CA  1 
ATOM   1183 C C   . TRP A 1 185 ? 161.604 125.463 141.917 1.00 50.42  ? 185 TRP A C   1 
ATOM   1184 O O   . TRP A 1 185 ? 160.677 125.466 142.734 1.00 50.42  ? 185 TRP A O   1 
ATOM   1185 C CB  . TRP A 1 185 ? 160.552 125.374 139.645 1.00 50.42  ? 185 TRP A CB  1 
ATOM   1186 N N   . SER A 1 186 ? 162.740 126.132 142.099 1.00 46.12  ? 186 SER A N   1 
ATOM   1187 C CA  . SER A 1 186 ? 162.973 126.898 143.311 1.00 46.12  ? 186 SER A CA  1 
ATOM   1188 C C   . SER A 1 186 ? 162.011 128.079 143.395 1.00 46.12  ? 186 SER A C   1 
ATOM   1189 O O   . SER A 1 186 ? 161.487 128.565 142.389 1.00 46.12  ? 186 SER A O   1 
ATOM   1190 C CB  . SER A 1 186 ? 164.418 127.393 143.364 1.00 46.12  ? 186 SER A CB  1 
ATOM   1191 N N   . LEU A 1 187 ? 161.778 128.538 144.625 1.00 43.53  ? 187 LEU A N   1 
ATOM   1192 C CA  . LEU A 1 187 ? 160.831 129.624 144.845 1.00 43.53  ? 187 LEU A CA  1 
ATOM   1193 C C   . LEU A 1 187 ? 161.341 130.957 144.313 1.00 43.53  ? 187 LEU A C   1 
ATOM   1194 O O   . LEU A 1 187 ? 160.540 131.877 144.116 1.00 43.53  ? 187 LEU A O   1 
ATOM   1195 C CB  . LEU A 1 187 ? 160.504 129.737 146.334 1.00 43.53  ? 187 LEU A CB  1 
ATOM   1196 C CG  . LEU A 1 187 ? 160.060 128.439 147.015 1.00 43.53  ? 187 LEU A CG  1 
ATOM   1197 C CD1 . LEU A 1 187 ? 159.622 128.698 148.448 1.00 43.53  ? 187 LEU A CD1 1 
ATOM   1198 C CD2 . LEU A 1 187 ? 158.947 127.761 146.230 1.00 43.53  ? 187 LEU A CD2 1 
ATOM   1199 N N   . PHE A 1 188 ? 162.647 131.081 144.068 1.00 38.48  ? 188 PHE A N   1 
ATOM   1200 C CA  . PHE A 1 188 ? 163.179 132.305 143.477 1.00 38.48  ? 188 PHE A CA  1 
ATOM   1201 C C   . PHE A 1 188 ? 162.685 132.487 142.046 1.00 38.48  ? 188 PHE A C   1 
ATOM   1202 O O   . PHE A 1 188 ? 162.241 133.576 141.664 1.00 38.48  ? 188 PHE A O   1 
ATOM   1203 C CB  . PHE A 1 188 ? 164.705 132.283 143.526 1.00 38.48  ? 188 PHE A CB  1 
ATOM   1204 C CG  . PHE A 1 188 ? 165.340 133.596 143.185 1.00 38.48  ? 188 PHE A CG  1 
ATOM   1205 C CD1 . PHE A 1 188 ? 165.369 134.625 144.108 1.00 38.48  ? 188 PHE A CD1 1 
ATOM   1206 C CD2 . PHE A 1 188 ? 165.917 133.798 141.944 1.00 38.48  ? 188 PHE A CD2 1 
ATOM   1207 C CE1 . PHE A 1 188 ? 165.956 135.833 143.798 1.00 38.48  ? 188 PHE A CE1 1 
ATOM   1208 C CE2 . PHE A 1 188 ? 166.506 135.003 141.628 1.00 38.48  ? 188 PHE A CE2 1 
ATOM   1209 C CZ  . PHE A 1 188 ? 166.526 136.023 142.556 1.00 38.48  ? 188 PHE A CZ  1 
ATOM   1210 N N   . SER A 1 189 ? 162.748 131.425 141.238 1.00 40.94  ? 189 SER A N   1 
ATOM   1211 C CA  . SER A 1 189 ? 162.226 131.503 139.878 1.00 40.94  ? 189 SER A CA  1 
ATOM   1212 C C   . SER A 1 189 ? 160.717 131.705 139.870 1.00 40.94  ? 189 SER A C   1 
ATOM   1213 O O   . SER A 1 189 ? 160.189 132.403 138.998 1.00 40.94  ? 189 SER A O   1 
ATOM   1214 C CB  . SER A 1 189 ? 162.598 130.242 139.099 1.00 40.94  ? 189 SER A CB  1 
ATOM   1215 O OG  . SER A 1 189 ? 163.989 129.984 139.185 1.00 40.94  ? 189 SER A OG  1 
ATOM   1216 N N   . LEU A 1 190 ? 160.011 131.108 140.829 1.00 37.03  ? 190 LEU A N   1 
ATOM   1217 C CA  . LEU A 1 190 ? 158.574 131.330 140.936 1.00 37.03  ? 190 LEU A CA  1 
ATOM   1218 C C   . LEU A 1 190 ? 158.273 132.787 141.271 1.00 37.03  ? 190 LEU A C   1 
ATOM   1219 O O   . LEU A 1 190 ? 157.310 133.369 140.755 1.00 37.03  ? 190 LEU A O   1 
ATOM   1220 C CB  . LEU A 1 190 ? 157.996 130.378 141.984 1.00 37.03  ? 190 LEU A CB  1 
ATOM   1221 C CG  . LEU A 1 190 ? 156.487 130.199 142.118 1.00 37.03  ? 190 LEU A CG  1 
ATOM   1222 C CD1 . LEU A 1 190 ? 156.187 128.795 142.600 1.00 37.03  ? 190 LEU A CD1 1 
ATOM   1223 C CD2 . LEU A 1 190 ? 155.934 131.201 143.091 1.00 37.03  ? 190 LEU A CD2 1 
ATOM   1224 N N   . ASN A 1 191 ? 159.095 133.396 142.125 1.00 35.71  ? 191 ASN A N   1 
ATOM   1225 C CA  . ASN A 1 191 ? 158.955 134.821 142.399 1.00 35.71  ? 191 ASN A CA  1 
ATOM   1226 C C   . ASN A 1 191 ? 159.259 135.656 141.163 1.00 35.71  ? 191 ASN A C   1 
ATOM   1227 O O   . ASN A 1 191 ? 158.635 136.701 140.949 1.00 35.71  ? 191 ASN A O   1 
ATOM   1228 C CB  . ASN A 1 191 ? 159.876 135.215 143.547 1.00 35.71  ? 191 ASN A CB  1 
ATOM   1229 C CG  . ASN A 1 191 ? 159.338 134.791 144.889 1.00 35.71  ? 191 ASN A CG  1 
ATOM   1230 O OD1 . ASN A 1 191 ? 158.139 134.865 145.139 1.00 35.71  ? 191 ASN A OD1 1 
ATOM   1231 N ND2 . ASN A 1 191 ? 160.226 134.343 145.766 1.00 35.71  ? 191 ASN A ND2 1 
ATOM   1232 N N   . VAL A 1 192 ? 160.219 135.216 140.348 1.00 34.82  ? 192 VAL A N   1 
ATOM   1233 C CA  . VAL A 1 192 ? 160.482 135.889 139.077 1.00 34.82  ? 192 VAL A CA  1 
ATOM   1234 C C   . VAL A 1 192 ? 159.253 135.819 138.178 1.00 34.82  ? 192 VAL A C   1 
ATOM   1235 O O   . VAL A 1 192 ? 158.911 136.790 137.494 1.00 34.82  ? 192 VAL A O   1 
ATOM   1236 C CB  . VAL A 1 192 ? 161.722 135.285 138.392 1.00 34.82  ? 192 VAL A CB  1 
ATOM   1237 C CG1 . VAL A 1 192 ? 161.918 135.889 137.013 1.00 34.82  ? 192 VAL A CG1 1 
ATOM   1238 C CG2 . VAL A 1 192 ? 162.959 135.510 139.240 1.00 34.82  ? 192 VAL A CG2 1 
ATOM   1239 N N   . ILE A 1 193 ? 158.575 134.669 138.161 1.00 33.16  ? 193 ILE A N   1 
ATOM   1240 C CA  . ILE A 1 193 ? 157.335 134.538 137.393 1.00 33.16  ? 193 ILE A CA  1 
ATOM   1241 C C   . ILE A 1 193 ? 156.273 135.493 137.922 1.00 33.16  ? 193 ILE A C   1 
ATOM   1242 O O   . ILE A 1 193 ? 155.534 136.117 137.150 1.00 33.16  ? 193 ILE A O   1 
ATOM   1243 C CB  . ILE A 1 193 ? 156.833 133.081 137.410 1.00 33.16  ? 193 ILE A CB  1 
ATOM   1244 C CG1 . ILE A 1 193 ? 157.906 132.129 136.883 1.00 33.16  ? 193 ILE A CG1 1 
ATOM   1245 C CG2 . ILE A 1 193 ? 155.552 132.946 136.604 1.00 33.16  ? 193 ILE A CG2 1 
ATOM   1246 C CD1 . ILE A 1 193 ? 157.536 130.668 137.004 1.00 33.16  ? 193 ILE A CD1 1 
ATOM   1247 N N   . SER A 1 194 ? 156.170 135.607 139.247 1.00 31.29  ? 194 SER A N   1 
ATOM   1248 C CA  . SER A 1 194 ? 155.208 136.533 139.840 1.00 31.29  ? 194 SER A CA  1 
ATOM   1249 C C   . SER A 1 194 ? 155.499 137.970 139.424 1.00 31.29  ? 194 SER A C   1 
ATOM   1250 O O   . SER A 1 194 ? 154.582 138.726 139.071 1.00 31.29  ? 194 SER A O   1 
ATOM   1251 C CB  . SER A 1 194 ? 155.236 136.403 141.361 1.00 31.29  ? 194 SER A CB  1 
ATOM   1252 O OG  . SER A 1 194 ? 154.879 135.096 141.765 1.00 31.29  ? 194 SER A OG  1 
ATOM   1253 N N   . LEU A 1 195 ? 156.776 138.360 139.456 1.00 32.00  ? 195 LEU A N   1 
ATOM   1254 C CA  . LEU A 1 195 ? 157.163 139.703 139.032 1.00 32.00  ? 195 LEU A CA  1 
ATOM   1255 C C   . LEU A 1 195 ? 156.889 139.916 137.549 1.00 32.00  ? 195 LEU A C   1 
ATOM   1256 O O   . LEU A 1 195 ? 156.454 140.999 137.142 1.00 32.00  ? 195 LEU A O   1 
ATOM   1257 C CB  . LEU A 1 195 ? 158.638 139.952 139.345 1.00 32.00  ? 195 LEU A CB  1 
ATOM   1258 C CG  . LEU A 1 195 ? 159.212 141.281 138.853 1.00 32.00  ? 195 LEU A CG  1 
ATOM   1259 C CD1 . LEU A 1 195 ? 158.565 142.456 139.565 1.00 32.00  ? 195 LEU A CD1 1 
ATOM   1260 C CD2 . LEU A 1 195 ? 160.715 141.308 139.033 1.00 32.00  ? 195 LEU A CD2 1 
ATOM   1261 N N   . THR A 1 196 ? 157.140 138.897 136.726 1.00 30.67  ? 196 THR A N   1 
ATOM   1262 C CA  . THR A 1 196 ? 156.847 138.999 135.301 1.00 30.67  ? 196 THR A CA  1 
ATOM   1263 C C   . THR A 1 196 ? 155.360 139.226 135.067 1.00 30.67  ? 196 THR A C   1 
ATOM   1264 O O   . THR A 1 196 ? 154.967 140.076 134.259 1.00 30.67  ? 196 THR A O   1 
ATOM   1265 C CB  . THR A 1 196 ? 157.315 137.733 134.582 1.00 30.67  ? 196 THR A CB  1 
ATOM   1266 O OG1 . THR A 1 196 ? 158.704 137.515 134.852 1.00 30.67  ? 196 THR A OG1 1 
ATOM   1267 C CG2 . THR A 1 196 ? 157.109 137.862 133.084 1.00 30.67  ? 196 THR A CG2 1 
ATOM   1268 N N   . CYS A 1 197 ? 154.517 138.478 135.780 1.00 31.51  ? 197 CYS A N   1 
ATOM   1269 C CA  . CYS A 1 197 ? 153.076 138.616 135.600 1.00 31.51  ? 197 CYS A CA  1 
ATOM   1270 C C   . CYS A 1 197 ? 152.581 139.980 136.067 1.00 31.51  ? 197 CYS A C   1 
ATOM   1271 O O   . CYS A 1 197 ? 151.737 140.595 135.406 1.00 31.51  ? 197 CYS A O   1 
ATOM   1272 C CB  . CYS A 1 197 ? 152.345 137.490 136.325 1.00 31.51  ? 197 CYS A CB  1 
ATOM   1273 S SG  . CYS A 1 197 ? 152.665 135.866 135.613 1.00 31.51  ? 197 CYS A SG  1 
ATOM   1274 N N   . VAL A 1 198 ? 153.099 140.482 137.191 1.00 32.43  ? 198 VAL A N   1 
ATOM   1275 C CA  . VAL A 1 198 ? 152.641 141.796 137.639 1.00 32.43  ? 198 VAL A CA  1 
ATOM   1276 C C   . VAL A 1 198 ? 153.179 142.904 136.734 1.00 32.43  ? 198 VAL A C   1 
ATOM   1277 O O   . VAL A 1 198 ? 152.515 143.931 136.543 1.00 32.43  ? 198 VAL A O   1 
ATOM   1278 C CB  . VAL A 1 198 ? 152.997 142.033 139.118 1.00 32.43  ? 198 VAL A CB  1 
ATOM   1279 C CG1 . VAL A 1 198 ? 152.393 140.936 139.979 1.00 32.43  ? 198 VAL A CG1 1 
ATOM   1280 C CG2 . VAL A 1 198 ? 154.490 142.113 139.317 1.00 32.43  ? 198 VAL A CG2 1 
ATOM   1281 N N   . SER A 1 199 ? 154.365 142.720 136.145 1.00 32.80  ? 199 SER A N   1 
ATOM   1282 C CA  . SER A 1 199 ? 154.861 143.688 135.171 1.00 32.80  ? 199 SER A CA  1 
ATOM   1283 C C   . SER A 1 199 ? 154.002 143.693 133.911 1.00 32.80  ? 199 SER A C   1 
ATOM   1284 O O   . SER A 1 199 ? 153.715 144.759 133.350 1.00 32.80  ? 199 SER A O   1 
ATOM   1285 C CB  . SER A 1 199 ? 156.318 143.383 134.828 1.00 32.80  ? 199 SER A CB  1 
ATOM   1286 O OG  . SER A 1 199 ? 156.829 144.317 133.895 1.00 32.80  ? 199 SER A OG  1 
ATOM   1287 N N   . VAL A 1 200 ? 153.591 142.509 133.449 1.00 30.80  ? 200 VAL A N   1 
ATOM   1288 C CA  . VAL A 1 200 ? 152.661 142.421 132.326 1.00 30.80  ? 200 VAL A CA  1 
ATOM   1289 C C   . VAL A 1 200 ? 151.349 143.108 132.677 1.00 30.80  ? 200 VAL A C   1 
ATOM   1290 O O   . VAL A 1 200 ? 150.740 143.790 131.842 1.00 30.80  ? 200 VAL A O   1 
ATOM   1291 C CB  . VAL A 1 200 ? 152.446 140.949 131.931 1.00 30.80  ? 200 VAL A CB  1 
ATOM   1292 C CG1 . VAL A 1 200 ? 151.299 140.821 130.952 1.00 30.80  ? 200 VAL A CG1 1 
ATOM   1293 C CG2 . VAL A 1 200 ? 153.713 140.372 131.335 1.00 30.80  ? 200 VAL A CG2 1 
ATOM   1294 N N   . ALA A 1 201 ? 150.898 142.944 133.921 1.00 33.24  ? 201 ALA A N   1 
ATOM   1295 C CA  . ALA A 1 201 ? 149.692 143.626 134.373 1.00 33.24  ? 201 ALA A CA  1 
ATOM   1296 C C   . ALA A 1 201 ? 149.855 145.137 134.313 1.00 33.24  ? 201 ALA A C   1 
ATOM   1297 O O   . ALA A 1 201 ? 148.938 145.850 133.894 1.00 33.24  ? 201 ALA A O   1 
ATOM   1298 C CB  . ALA A 1 201 ? 149.347 143.188 135.791 1.00 33.24  ? 201 ALA A CB  1 
ATOM   1299 N N   . PHE A 1 202 ? 151.012 145.645 134.741 1.00 32.28  ? 202 PHE A N   1 
ATOM   1300 C CA  . PHE A 1 202 ? 151.266 147.082 134.665 1.00 32.28  ? 202 PHE A CA  1 
ATOM   1301 C C   . PHE A 1 202 ? 151.265 147.564 133.219 1.00 32.28  ? 202 PHE A C   1 
ATOM   1302 O O   . PHE A 1 202 ? 150.712 148.628 132.909 1.00 32.28  ? 202 PHE A O   1 
ATOM   1303 C CB  . PHE A 1 202 ? 152.597 147.413 135.340 1.00 32.28  ? 202 PHE A CB  1 
ATOM   1304 C CG  . PHE A 1 202 ? 152.971 148.871 135.278 1.00 32.28  ? 202 PHE A CG  1 
ATOM   1305 C CD1 . PHE A 1 202 ? 152.541 149.750 136.254 1.00 32.28  ? 202 PHE A CD1 1 
ATOM   1306 C CD2 . PHE A 1 202 ? 153.769 149.357 134.253 1.00 32.28  ? 202 PHE A CD2 1 
ATOM   1307 C CE1 . PHE A 1 202 ? 152.888 151.085 136.203 1.00 32.28  ? 202 PHE A CE1 1 
ATOM   1308 C CE2 . PHE A 1 202 ? 154.116 150.691 134.196 1.00 32.28  ? 202 PHE A CE2 1 
ATOM   1309 C CZ  . PHE A 1 202 ? 153.676 151.555 135.173 1.00 32.28  ? 202 PHE A CZ  1 
ATOM   1310 N N   . ALA A 1 203 ? 151.888 146.794 132.324 1.00 35.06  ? 203 ALA A N   1 
ATOM   1311 C CA  . ALA A 1 203 ? 151.913 147.166 130.913 1.00 35.06  ? 203 ALA A CA  1 
ATOM   1312 C C   . ALA A 1 203 ? 150.506 147.216 130.333 1.00 35.06  ? 203 ALA A C   1 
ATOM   1313 O O   . ALA A 1 203 ? 150.180 148.113 129.548 1.00 35.06  ? 203 ALA A O   1 
ATOM   1314 C CB  . ALA A 1 203 ? 152.787 146.190 130.127 1.00 35.06  ? 203 ALA A CB  1 
ATOM   1315 N N   . VAL A 1 204 ? 149.660 146.253 130.704 1.00 37.31  ? 204 VAL A N   1 
ATOM   1316 C CA  . VAL A 1 204 ? 148.269 146.273 130.259 1.00 37.31  ? 204 VAL A CA  1 
ATOM   1317 C C   . VAL A 1 204 ? 147.543 147.483 130.832 1.00 37.31  ? 204 VAL A C   1 
ATOM   1318 O O   . VAL A 1 204 ? 146.775 148.154 130.133 1.00 37.31  ? 204 VAL A O   1 
ATOM   1319 C CB  . VAL A 1 204 ? 147.565 144.959 130.642 1.00 37.31  ? 204 VAL A CB  1 
ATOM   1320 C CG1 . VAL A 1 204 ? 146.082 145.056 130.351 1.00 37.31  ? 204 VAL A CG1 1 
ATOM   1321 C CG2 . VAL A 1 204 ? 148.179 143.792 129.888 1.00 37.31  ? 204 VAL A CG2 1 
ATOM   1322 N N   . ALA A 1 205 ? 147.779 147.783 132.111 1.00 40.24  ? 205 ALA A N   1 
ATOM   1323 C CA  . ALA A 1 205 ? 147.083 148.886 132.763 1.00 40.24  ? 205 ALA A CA  1 
ATOM   1324 C C   . ALA A 1 205 ? 147.477 150.235 132.183 1.00 40.24  ? 205 ALA A C   1 
ATOM   1325 O O   . ALA A 1 205 ? 146.689 151.185 132.246 1.00 40.24  ? 205 ALA A O   1 
ATOM   1326 C CB  . ALA A 1 205 ? 147.359 148.868 134.265 1.00 40.24  ? 205 ALA A CB  1 
ATOM   1327 N N   . TRP A 1 206 ? 148.686 150.345 131.629 1.00 40.64  ? 206 TRP A N   1 
ATOM   1328 C CA  . TRP A 1 206 ? 149.142 151.644 131.145 1.00 40.64  ? 206 TRP A CA  1 
ATOM   1329 C C   . TRP A 1 206 ? 148.321 152.175 129.975 1.00 40.64  ? 206 TRP A C   1 
ATOM   1330 O O   . TRP A 1 206 ? 148.333 153.387 129.736 1.00 40.64  ? 206 TRP A O   1 
ATOM   1331 C CB  . TRP A 1 206 ? 150.614 151.588 130.738 1.00 40.64  ? 206 TRP A CB  1 
ATOM   1332 C CG  . TRP A 1 206 ? 151.218 152.954 130.601 1.00 40.64  ? 206 TRP A CG  1 
ATOM   1333 C CD1 . TRP A 1 206 ? 151.541 153.812 131.611 1.00 40.64  ? 206 TRP A CD1 1 
ATOM   1334 C CD2 . TRP A 1 206 ? 151.545 153.628 129.381 1.00 40.64  ? 206 TRP A CD2 1 
ATOM   1335 N NE1 . TRP A 1 206 ? 152.060 154.975 131.096 1.00 40.64  ? 206 TRP A NE1 1 
ATOM   1336 C CE2 . TRP A 1 206 ? 152.072 154.887 129.729 1.00 40.64  ? 206 TRP A CE2 1 
ATOM   1337 C CE3 . TRP A 1 206 ? 151.449 153.288 128.029 1.00 40.64  ? 206 TRP A CE3 1 
ATOM   1338 C CZ2 . TRP A 1 206 ? 152.503 155.805 128.775 1.00 40.64  ? 206 TRP A CZ2 1 
ATOM   1339 C CZ3 . TRP A 1 206 ? 151.876 154.200 127.083 1.00 40.64  ? 206 TRP A CZ3 1 
ATOM   1340 C CH2 . TRP A 1 206 ? 152.396 155.443 127.460 1.00 40.64  ? 206 TRP A CH2 1 
ATOM   1341 N N   . PHE A 1 207 ? 147.610 151.318 129.242 1.00 45.34  ? 207 PHE A N   1 
ATOM   1342 C CA  . PHE A 1 207 ? 146.863 151.773 128.073 1.00 45.34  ? 207 PHE A CA  1 
ATOM   1343 C C   . PHE A 1 207 ? 145.356 151.625 128.294 1.00 45.34  ? 207 PHE A C   1 
ATOM   1344 O O   . PHE A 1 207 ? 144.575 151.633 127.339 1.00 45.34  ? 207 PHE A O   1 
ATOM   1345 C CB  . PHE A 1 207 ? 147.358 151.024 126.826 1.00 45.34  ? 207 PHE A CB  1 
ATOM   1346 C CG  . PHE A 1 207 ? 146.705 151.450 125.533 1.00 45.34  ? 207 PHE A CG  1 
ATOM   1347 C CD1 . PHE A 1 207 ? 147.063 152.648 124.934 1.00 45.34  ? 207 PHE A CD1 1 
ATOM   1348 C CD2 . PHE A 1 207 ? 145.791 150.632 124.886 1.00 45.34  ? 207 PHE A CD2 1 
ATOM   1349 C CE1 . PHE A 1 207 ? 146.487 153.046 123.745 1.00 45.34  ? 207 PHE A CE1 1 
ATOM   1350 C CE2 . PHE A 1 207 ? 145.209 151.027 123.695 1.00 45.34  ? 207 PHE A CE2 1 
ATOM   1351 C CZ  . PHE A 1 207 ? 145.561 152.234 123.122 1.00 45.34  ? 207 PHE A CZ  1 
ATOM   1352 N N   . LEU A 1 208 ? 144.930 151.531 129.548 1.00 43.45  ? 208 LEU A N   1 
ATOM   1353 C CA  . LEU A 1 208 ? 143.508 151.506 129.849 1.00 43.45  ? 208 LEU A CA  1 
ATOM   1354 C C   . LEU A 1 208 ? 142.853 152.803 129.379 1.00 43.45  ? 208 LEU A C   1 
ATOM   1355 O O   . LEU A 1 208 ? 143.456 153.877 129.490 1.00 43.45  ? 208 LEU A O   1 
ATOM   1356 C CB  . LEU A 1 208 ? 143.284 151.326 131.350 1.00 43.45  ? 208 LEU A CB  1 
ATOM   1357 C CG  . LEU A 1 208 ? 143.404 149.920 131.928 1.00 43.45  ? 208 LEU A CG  1 
ATOM   1358 C CD1 . LEU A 1 208 ? 143.610 149.989 133.425 1.00 43.45  ? 208 LEU A CD1 1 
ATOM   1359 C CD2 . LEU A 1 208 ? 142.143 149.146 131.617 1.00 43.45  ? 208 LEU A CD2 1 
ATOM   1360 N N   . PRO A 1 209 ? 141.643 152.741 128.827 1.00 46.33  ? 209 PRO A N   1 
ATOM   1361 C CA  . PRO A 1 209 ? 140.960 153.973 128.418 1.00 46.33  ? 209 PRO A CA  1 
ATOM   1362 C C   . PRO A 1 209 ? 140.678 154.865 129.616 1.00 46.33  ? 209 PRO A C   1 
ATOM   1363 O O   . PRO A 1 209 ? 140.327 154.390 130.698 1.00 46.33  ? 209 PRO A O   1 
ATOM   1364 C CB  . PRO A 1 209 ? 139.668 153.464 127.773 1.00 46.33  ? 209 PRO A CB  1 
ATOM   1365 C CG  . PRO A 1 209 ? 139.450 152.125 128.381 1.00 46.33  ? 209 PRO A CG  1 
ATOM   1366 C CD  . PRO A 1 209 ? 140.816 151.548 128.588 1.00 46.33  ? 209 PRO A CD  1 
ATOM   1367 N N   . MET A 1 210 ? 140.833 156.169 129.413 1.00 53.44  ? 210 MET A N   1 
ATOM   1368 C CA  . MET A 1 210 ? 140.662 157.091 130.521 1.00 53.44  ? 210 MET A CA  1 
ATOM   1369 C C   . MET A 1 210 ? 139.183 157.262 130.861 1.00 53.44  ? 210 MET A C   1 
ATOM   1370 O O   . MET A 1 210 ? 138.323 157.222 129.976 1.00 53.44  ? 210 MET A O   1 
ATOM   1371 C CB  . MET A 1 210 ? 141.281 158.447 130.193 1.00 53.44  ? 210 MET A CB  1 
ATOM   1372 C CG  . MET A 1 210 ? 140.609 159.199 129.056 1.00 53.44  ? 210 MET A CG  1 
ATOM   1373 S SD  . MET A 1 210 ? 141.417 160.768 128.684 1.00 53.44  ? 210 MET A SD  1 
ATOM   1374 C CE  . MET A 1 210 ? 140.405 161.357 127.328 1.00 53.44  ? 210 MET A CE  1 
ATOM   1375 N N   . PRO A 1 211 ? 138.862 157.428 132.142 1.00 55.23  ? 211 PRO A N   1 
ATOM   1376 C CA  . PRO A 1 211 ? 137.470 157.700 132.560 1.00 55.23  ? 211 PRO A CA  1 
ATOM   1377 C C   . PRO A 1 211 ? 137.058 159.147 132.303 1.00 55.23  ? 211 PRO A C   1 
ATOM   1378 O O   . PRO A 1 211 ? 137.114 160.023 133.166 1.00 55.23  ? 211 PRO A O   1 
ATOM   1379 C CB  . PRO A 1 211 ? 137.495 157.368 134.055 1.00 55.23  ? 211 PRO A CB  1 
ATOM   1380 C CG  . PRO A 1 211 ? 138.757 156.602 134.279 1.00 55.23  ? 211 PRO A CG  1 
ATOM   1381 C CD  . PRO A 1 211 ? 139.726 157.142 133.293 1.00 55.23  ? 211 PRO A CD  1 
ATOM   1382 N N   . GLN A 1 212 ? 136.641 159.409 131.062 1.00 61.63  ? 212 GLN A N   1 
ATOM   1383 C CA  . GLN A 1 212 ? 136.146 160.736 130.715 1.00 61.63  ? 212 GLN A CA  1 
ATOM   1384 C C   . GLN A 1 212 ? 134.899 161.087 131.513 1.00 61.63  ? 212 GLN A C   1 
ATOM   1385 O O   . GLN A 1 212 ? 134.737 162.235 131.940 1.00 61.63  ? 212 GLN A O   1 
ATOM   1386 C CB  . GLN A 1 212 ? 135.862 160.815 129.216 1.00 61.63  ? 212 GLN A CB  1 
ATOM   1387 C CG  . GLN A 1 212 ? 135.404 162.183 128.743 1.00 61.63  ? 212 GLN A CG  1 
ATOM   1388 C CD  . GLN A 1 212 ? 136.447 163.260 128.975 1.00 61.63  ? 212 GLN A CD  1 
ATOM   1389 O OE1 . GLN A 1 212 ? 136.326 164.070 129.893 1.00 61.63  ? 212 GLN A OE1 1 
ATOM   1390 N NE2 . GLN A 1 212 ? 137.478 163.275 128.137 1.00 61.63  ? 212 GLN A NE2 1 
ATOM   1391 N N   . LYS A 1 213 ? 134.016 160.118 131.727 1.00 63.95  ? 213 LYS A N   1 
ATOM   1392 C CA  . LYS A 1 213 ? 132.835 160.326 132.553 1.00 63.95  ? 213 LYS A CA  1 
ATOM   1393 C C   . LYS A 1 213 ? 133.161 160.053 134.016 1.00 63.95  ? 213 LYS A C   1 
ATOM   1394 O O   . LYS A 1 213 ? 134.285 159.676 134.349 1.00 63.95  ? 213 LYS A O   1 
ATOM   1395 C CB  . LYS A 1 213 ? 131.684 159.431 132.088 1.00 63.95  ? 213 LYS A CB  1 
ATOM   1396 N N   . VAL A 1 278 ? 129.587 169.773 152.474 1.00 116.24 ? 278 VAL A N   1 
ATOM   1397 C CA  . VAL A 1 278 ? 129.560 168.519 151.733 1.00 116.24 ? 278 VAL A CA  1 
ATOM   1398 C C   . VAL A 1 278 ? 129.981 167.366 152.635 1.00 116.24 ? 278 VAL A C   1 
ATOM   1399 O O   . VAL A 1 278 ? 129.326 166.326 152.669 1.00 116.24 ? 278 VAL A O   1 
ATOM   1400 C CB  . VAL A 1 278 ? 130.456 168.588 150.485 1.00 116.24 ? 278 VAL A CB  1 
ATOM   1401 N N   . LEU A 1 279 ? 131.087 167.559 153.360 1.00 116.79 ? 279 LEU A N   1 
ATOM   1402 C CA  . LEU A 1 279 ? 131.562 166.525 154.275 1.00 116.79 ? 279 LEU A CA  1 
ATOM   1403 C C   . LEU A 1 279 ? 130.562 166.280 155.398 1.00 116.79 ? 279 LEU A C   1 
ATOM   1404 O O   . LEU A 1 279 ? 130.308 165.130 155.773 1.00 116.79 ? 279 LEU A O   1 
ATOM   1405 C CB  . LEU A 1 279 ? 132.925 166.915 154.845 1.00 116.79 ? 279 LEU A CB  1 
ATOM   1406 N N   . LYS A 1 280 ? 129.995 167.352 155.956 1.00 116.96 ? 280 LYS A N   1 
ATOM   1407 C CA  . LYS A 1 280 ? 128.947 167.196 156.960 1.00 116.96 ? 280 LYS A CA  1 
ATOM   1408 C C   . LYS A 1 280 ? 127.699 166.562 156.357 1.00 116.96 ? 280 LYS A C   1 
ATOM   1409 O O   . LYS A 1 280 ? 127.063 165.709 156.987 1.00 116.96 ? 280 LYS A O   1 
ATOM   1410 C CB  . LYS A 1 280 ? 128.616 168.549 157.588 1.00 116.96 ? 280 LYS A CB  1 
ATOM   1411 N N   . VAL A 1 281 ? 127.333 166.969 155.139 1.00 116.64 ? 281 VAL A N   1 
ATOM   1412 C CA  . VAL A 1 281 ? 126.169 166.391 154.476 1.00 116.64 ? 281 VAL A CA  1 
ATOM   1413 C C   . VAL A 1 281 ? 126.412 164.922 154.149 1.00 116.64 ? 281 VAL A C   1 
ATOM   1414 O O   . VAL A 1 281 ? 125.517 164.082 154.305 1.00 116.64 ? 281 VAL A O   1 
ATOM   1415 C CB  . VAL A 1 281 ? 125.816 167.202 153.216 1.00 116.64 ? 281 VAL A CB  1 
ATOM   1416 N N   . LEU A 1 282 ? 127.617 164.591 153.676 1.00 115.93 ? 282 LEU A N   1 
ATOM   1417 C CA  . LEU A 1 282 ? 127.957 163.193 153.431 1.00 115.93 ? 282 LEU A CA  1 
ATOM   1418 C C   . LEU A 1 282 ? 127.944 162.393 154.726 1.00 115.93 ? 282 LEU A C   1 
ATOM   1419 O O   . LEU A 1 282 ? 127.470 161.252 154.756 1.00 115.93 ? 282 LEU A O   1 
ATOM   1420 C CB  . LEU A 1 282 ? 129.322 163.094 152.751 1.00 115.93 ? 282 LEU A CB  1 
ATOM   1421 N N   . TRP A 1 283 ? 128.467 162.976 155.808 1.00 115.08 ? 283 TRP A N   1 
ATOM   1422 C CA  . TRP A 1 283 ? 128.368 162.334 157.114 1.00 115.08 ? 283 TRP A CA  1 
ATOM   1423 C C   . TRP A 1 283 ? 126.916 162.235 157.564 1.00 115.08 ? 283 TRP A C   1 
ATOM   1424 O O   . TRP A 1 283 ? 126.514 161.238 158.176 1.00 115.08 ? 283 TRP A O   1 
ATOM   1425 C CB  . TRP A 1 283 ? 129.201 163.102 158.141 1.00 115.08 ? 283 TRP A CB  1 
ATOM   1426 N N   . ASN A 1 284 ? 126.117 163.267 157.279 1.00 115.90 ? 284 ASN A N   1 
ATOM   1427 C CA  . ASN A 1 284 ? 124.683 163.184 157.536 1.00 115.90 ? 284 ASN A CA  1 
ATOM   1428 C C   . ASN A 1 284 ? 124.040 162.096 156.686 1.00 115.90 ? 284 ASN A C   1 
ATOM   1429 O O   . ASN A 1 284 ? 123.170 161.358 157.162 1.00 115.90 ? 284 ASN A O   1 
ATOM   1430 C CB  . ASN A 1 284 ? 124.021 164.537 157.273 1.00 115.90 ? 284 ASN A CB  1 
ATOM   1431 N N   . ASP A 1 285 ? 124.451 161.988 155.419 1.00 112.49 ? 285 ASP A N   1 
ATOM   1432 C CA  . ASP A 1 285 ? 124.005 160.874 154.590 1.00 112.49 ? 285 ASP A CA  1 
ATOM   1433 C C   . ASP A 1 285 ? 124.568 159.551 155.088 1.00 112.49 ? 285 ASP A C   1 
ATOM   1434 O O   . ASP A 1 285 ? 123.904 158.514 154.976 1.00 112.49 ? 285 ASP A O   1 
ATOM   1435 C CB  . ASP A 1 285 ? 124.402 161.108 153.133 1.00 112.49 ? 285 ASP A CB  1 
ATOM   1436 N N   . PHE A 1 286 ? 125.789 159.564 155.630 1.00 112.88 ? 286 PHE A N   1 
ATOM   1437 C CA  . PHE A 1 286 ? 126.332 158.364 156.258 1.00 112.88 ? 286 PHE A CA  1 
ATOM   1438 C C   . PHE A 1 286 ? 125.507 157.966 157.474 1.00 112.88 ? 286 PHE A C   1 
ATOM   1439 O O   . PHE A 1 286 ? 125.343 156.774 157.761 1.00 112.88 ? 286 PHE A O   1 
ATOM   1440 C CB  . PHE A 1 286 ? 127.793 158.587 156.647 1.00 112.88 ? 286 PHE A CB  1 
ATOM   1441 N N   . LEU A 1 287 ? 124.990 158.953 158.211 1.00 111.08 ? 287 LEU A N   1 
ATOM   1442 C CA  . LEU A 1 287 ? 124.043 158.656 159.281 1.00 111.08 ? 287 LEU A CA  1 
ATOM   1443 C C   . LEU A 1 287 ? 122.772 158.031 158.723 1.00 111.08 ? 287 LEU A C   1 
ATOM   1444 O O   . LEU A 1 287 ? 122.228 157.084 159.303 1.00 111.08 ? 287 LEU A O   1 
ATOM   1445 C CB  . LEU A 1 287 ? 123.720 159.927 160.067 1.00 111.08 ? 287 LEU A CB  1 
ATOM   1446 N N   . MET A 1 288 ? 122.286 158.546 157.590 1.00 109.22 ? 288 MET A N   1 
ATOM   1447 C CA  . MET A 1 288 ? 121.127 157.957 156.932 1.00 109.22 ? 288 MET A CA  1 
ATOM   1448 C C   . MET A 1 288 ? 121.431 156.585 156.346 1.00 109.22 ? 288 MET A C   1 
ATOM   1449 O O   . MET A 1 288 ? 120.500 155.808 156.107 1.00 109.22 ? 288 MET A O   1 
ATOM   1450 C CB  . MET A 1 288 ? 120.614 158.890 155.833 1.00 109.22 ? 288 MET A CB  1 
ATOM   1451 N N   . CYS A 1 289 ? 122.707 156.271 156.110 1.00 104.91 ? 289 CYS A N   1 
ATOM   1452 C CA  . CYS A 1 289 ? 123.075 154.936 155.654 1.00 104.91 ? 289 CYS A CA  1 
ATOM   1453 C C   . CYS A 1 289 ? 122.822 153.878 156.718 1.00 104.91 ? 289 CYS A C   1 
ATOM   1454 O O   . CYS A 1 289 ? 122.817 152.684 156.399 1.00 104.91 ? 289 CYS A O   1 
ATOM   1455 C CB  . CYS A 1 289 ? 124.545 154.908 155.230 1.00 104.91 ? 289 CYS A CB  1 
ATOM   1456 N N   . TYR A 1 290 ? 122.620 154.289 157.972 1.00 99.13  ? 290 TYR A N   1 
ATOM   1457 C CA  . TYR A 1 290 ? 122.269 153.374 159.049 1.00 99.13  ? 290 TYR A CA  1 
ATOM   1458 C C   . TYR A 1 290 ? 121.060 153.852 159.844 1.00 99.13  ? 290 TYR A C   1 
ATOM   1459 O O   . TYR A 1 290 ? 120.782 153.299 160.915 1.00 99.13  ? 290 TYR A O   1 
ATOM   1460 C CB  . TYR A 1 290 ? 123.462 153.169 159.990 1.00 99.13  ? 290 TYR A CB  1 
ATOM   1461 N N   . SER A 1 291 ? 120.334 154.854 159.356 1.00 101.21 ? 291 SER A N   1 
ATOM   1462 C CA  . SER A 1 291 ? 119.171 155.388 160.067 1.00 101.21 ? 291 SER A CA  1 
ATOM   1463 C C   . SER A 1 291 ? 117.886 154.679 159.654 1.00 101.21 ? 291 SER A C   1 
ATOM   1464 O O   . SER A 1 291 ? 116.888 155.304 159.298 1.00 101.21 ? 291 SER A O   1 
ATOM   1465 C CB  . SER A 1 291 ? 119.064 156.890 159.836 1.00 101.21 ? 291 SER A CB  1 
ATOM   1466 N N   . SER A 1 292 ? 117.911 153.350 159.709 1.00 95.09  ? 292 SER A N   1 
ATOM   1467 C CA  . SER A 1 292 ? 116.744 152.534 159.405 1.00 95.09  ? 292 SER A CA  1 
ATOM   1468 C C   . SER A 1 292 ? 116.965 151.154 160.006 1.00 95.09  ? 292 SER A C   1 
ATOM   1469 O O   . SER A 1 292 ? 118.071 150.810 160.431 1.00 95.09  ? 292 SER A O   1 
ATOM   1470 C CB  . SER A 1 292 ? 116.491 152.450 157.896 1.00 95.09  ? 292 SER A CB  1 
ATOM   1471 N N   . ARG A 1 293 ? 115.888 150.370 160.049 1.00 88.78  ? 293 ARG A N   1 
ATOM   1472 C CA  . ARG A 1 293 ? 115.977 149.021 160.605 1.00 88.78  ? 293 ARG A CA  1 
ATOM   1473 C C   . ARG A 1 293 ? 116.947 148.137 159.837 1.00 88.78  ? 293 ARG A C   1 
ATOM   1474 O O   . ARG A 1 293 ? 117.806 147.501 160.472 1.00 88.78  ? 293 ARG A O   1 
ATOM   1475 C CB  . ARG A 1 293 ? 114.580 148.394 160.655 1.00 88.78  ? 293 ARG A CB  1 
ATOM   1476 N N   . PRO A 1 294 ? 116.885 148.047 158.508 1.00 83.76  ? 294 PRO A N   1 
ATOM   1477 C CA  . PRO A 1 294 ? 117.823 147.174 157.790 1.00 83.76  ? 294 PRO A CA  1 
ATOM   1478 C C   . PRO A 1 294 ? 119.078 147.907 157.343 1.00 83.76  ? 294 PRO A C   1 
ATOM   1479 O O   . PRO A 1 294 ? 120.057 147.277 156.931 1.00 83.76  ? 294 PRO A O   1 
ATOM   1480 C CB  . PRO A 1 294 ? 117.000 146.686 156.592 1.00 83.76  ? 294 PRO A CB  1 
ATOM   1481 N N   . LEU A 1 295 ? 119.056 149.240 157.413 1.00 87.33  ? 295 LEU A N   1 
ATOM   1482 C CA  . LEU A 1 295 ? 120.204 150.025 156.966 1.00 87.33  ? 295 LEU A CA  1 
ATOM   1483 C C   . LEU A 1 295 ? 121.435 149.747 157.819 1.00 87.33  ? 295 LEU A C   1 
ATOM   1484 O O   . LEU A 1 295 ? 122.546 149.615 157.292 1.00 87.33  ? 295 LEU A O   1 
ATOM   1485 C CB  . LEU A 1 295 ? 119.860 151.513 156.989 1.00 87.33  ? 295 LEU A CB  1 
ATOM   1486 N N   . LEU A 1 296 ? 121.259 149.658 159.138 1.00 84.90  ? 296 LEU A N   1 
ATOM   1487 C CA  . LEU A 1 296 ? 122.379 149.328 160.014 1.00 84.90  ? 296 LEU A CA  1 
ATOM   1488 C C   . LEU A 1 296 ? 122.762 147.858 159.893 1.00 84.90  ? 296 LEU A C   1 
ATOM   1489 O O   . LEU A 1 296 ? 123.929 147.496 160.080 1.00 84.90  ? 296 LEU A O   1 
ATOM   1490 C CB  . LEU A 1 296 ? 122.028 149.668 161.463 1.00 84.90  ? 296 LEU A CB  1 
ATOM   1491 C CG  . LEU A 1 296 ? 123.154 149.547 162.494 1.00 84.90  ? 296 LEU A CG  1 
ATOM   1492 C CD1 . LEU A 1 296 ? 124.420 150.233 161.995 1.00 84.90  ? 296 LEU A CD1 1 
ATOM   1493 C CD2 . LEU A 1 296 ? 122.726 150.098 163.850 1.00 84.90  ? 296 LEU A CD2 1 
ATOM   1494 N N   . CYS A 1 297 ? 121.795 147.001 159.581 1.00 75.15  ? 297 CYS A N   1 
ATOM   1495 C CA  . CYS A 1 297 ? 122.018 145.563 159.617 1.00 75.15  ? 297 CYS A CA  1 
ATOM   1496 C C   . CYS A 1 297 ? 123.017 145.121 158.554 1.00 75.15  ? 297 CYS A C   1 
ATOM   1497 O O   . CYS A 1 297 ? 123.216 145.785 157.533 1.00 75.15  ? 297 CYS A O   1 
ATOM   1498 C CB  . CYS A 1 297 ? 120.699 144.811 159.435 1.00 75.15  ? 297 CYS A CB  1 
ATOM   1499 S SG  . CYS A 1 297 ? 119.565 144.939 160.835 1.00 75.15  ? 297 CYS A SG  1 
ATOM   1500 N N   . TRP A 1 298 ? 123.689 144.009 158.855 1.00 68.37  ? 298 TRP A N   1 
ATOM   1501 C CA  . TRP A 1 298 ? 124.675 143.320 158.027 1.00 68.37  ? 298 TRP A CA  1 
ATOM   1502 C C   . TRP A 1 298 ? 125.980 144.101 157.914 1.00 68.37  ? 298 TRP A C   1 
ATOM   1503 O O   . TRP A 1 298 ? 127.004 143.535 157.528 1.00 68.37  ? 298 TRP A O   1 
ATOM   1504 C CB  . TRP A 1 298 ? 124.098 142.994 156.644 1.00 68.37  ? 298 TRP A CB  1 
ATOM   1505 C CG  . TRP A 1 298 ? 122.751 142.348 156.728 1.00 68.37  ? 298 TRP A CG  1 
ATOM   1506 C CD1 . TRP A 1 298 ? 122.493 141.056 157.076 1.00 68.37  ? 298 TRP A CD1 1 
ATOM   1507 C CD2 . TRP A 1 298 ? 121.479 142.946 156.436 1.00 68.37  ? 298 TRP A CD2 1 
ATOM   1508 N NE1 . TRP A 1 298 ? 121.142 140.815 157.038 1.00 68.37  ? 298 TRP A NE1 1 
ATOM   1509 C CE2 . TRP A 1 298 ? 120.498 141.957 156.642 1.00 68.37  ? 298 TRP A CE2 1 
ATOM   1510 C CE3 . TRP A 1 298 ? 121.074 144.216 156.015 1.00 68.37  ? 298 TRP A CE3 1 
ATOM   1511 C CZ2 . TRP A 1 298 ? 119.142 142.199 156.451 1.00 68.37  ? 298 TRP A CZ2 1 
ATOM   1512 C CZ3 . TRP A 1 298 ? 119.725 144.454 155.827 1.00 68.37  ? 298 TRP A CZ3 1 
ATOM   1513 C CH2 . TRP A 1 298 ? 118.775 143.451 156.045 1.00 68.37  ? 298 TRP A CH2 1 
ATOM   1514 N N   . SER A 1 299 ? 125.999 145.347 158.387 1.00 67.44  ? 299 SER A N   1 
ATOM   1515 C CA  . SER A 1 299 ? 127.150 146.214 158.149 1.00 67.44  ? 299 SER A CA  1 
ATOM   1516 C C   . SER A 1 299 ? 128.319 145.878 159.072 1.00 67.44  ? 299 SER A C   1 
ATOM   1517 O O   . SER A 1 299 ? 129.420 145.552 158.609 1.00 67.44  ? 299 SER A O   1 
ATOM   1518 C CB  . SER A 1 299 ? 126.737 147.678 158.316 1.00 67.44  ? 299 SER A CB  1 
ATOM   1519 O OG  . SER A 1 299 ? 125.602 147.976 157.520 1.00 67.44  ? 299 SER A OG  1 
ATOM   1520 N N   . VAL A 1 300 ? 128.102 145.970 160.387 1.00 61.49  ? 300 VAL A N   1 
ATOM   1521 C CA  . VAL A 1 300 ? 129.191 145.720 161.325 1.00 61.49  ? 300 VAL A CA  1 
ATOM   1522 C C   . VAL A 1 300 ? 129.607 144.257 161.289 1.00 61.49  ? 300 VAL A C   1 
ATOM   1523 O O   . VAL A 1 300 ? 130.778 143.936 161.505 1.00 61.49  ? 300 VAL A O   1 
ATOM   1524 C CB  . VAL A 1 300 ? 128.808 146.175 162.749 1.00 61.49  ? 300 VAL A CB  1 
ATOM   1525 C CG1 . VAL A 1 300 ? 128.543 147.675 162.772 1.00 61.49  ? 300 VAL A CG1 1 
ATOM   1526 C CG2 . VAL A 1 300 ? 127.607 145.408 163.267 1.00 61.49  ? 300 VAL A CG2 1 
ATOM   1527 N N   . TRP A 1 301 ? 128.670 143.351 161.009 1.00 61.72  ? 301 TRP A N   1 
ATOM   1528 C CA  . TRP A 1 301 ? 129.033 141.947 160.829 1.00 61.72  ? 301 TRP A CA  1 
ATOM   1529 C C   . TRP A 1 301 ? 129.819 141.704 159.543 1.00 61.72  ? 301 TRP A C   1 
ATOM   1530 O O   . TRP A 1 301 ? 130.759 140.901 159.547 1.00 61.72  ? 301 TRP A O   1 
ATOM   1531 C CB  . TRP A 1 301 ? 127.790 141.062 160.939 1.00 61.72  ? 301 TRP A CB  1 
ATOM   1532 C CG  . TRP A 1 301 ? 126.938 141.418 162.128 1.00 61.72  ? 301 TRP A CG  1 
ATOM   1533 C CD1 . TRP A 1 301 ? 127.018 140.850 163.366 1.00 61.72  ? 301 TRP A CD1 1 
ATOM   1534 C CD2 . TRP A 1 301 ? 125.973 142.472 162.241 1.00 61.72  ? 301 TRP A CD2 1 
ATOM   1535 N NE1 . TRP A 1 301 ? 126.125 141.439 164.223 1.00 61.72  ? 301 TRP A NE1 1 
ATOM   1536 C CE2 . TRP A 1 301 ? 125.476 142.445 163.560 1.00 61.72  ? 301 TRP A CE2 1 
ATOM   1537 C CE3 . TRP A 1 301 ? 125.467 143.421 161.354 1.00 61.72  ? 301 TRP A CE3 1 
ATOM   1538 C CZ2 . TRP A 1 301 ? 124.498 143.327 164.008 1.00 61.72  ? 301 TRP A CZ2 1 
ATOM   1539 C CZ3 . TRP A 1 301 ? 124.494 144.299 161.803 1.00 61.72  ? 301 TRP A CZ3 1 
ATOM   1540 C CH2 . TRP A 1 301 ? 124.019 144.244 163.116 1.00 61.72  ? 301 TRP A CH2 1 
ATOM   1541 N N   . TRP A 1 302 ? 129.503 142.406 158.448 1.00 56.51  ? 302 TRP A N   1 
ATOM   1542 C CA  . TRP A 1 302 ? 130.385 142.332 157.288 1.00 56.51  ? 302 TRP A CA  1 
ATOM   1543 C C   . TRP A 1 302 ? 131.783 142.807 157.643 1.00 56.51  ? 302 TRP A C   1 
ATOM   1544 O O   . TRP A 1 302 ? 132.774 142.143 157.322 1.00 56.51  ? 302 TRP A O   1 
ATOM   1545 C CB  . TRP A 1 302 ? 129.831 143.168 156.136 1.00 56.51  ? 302 TRP A CB  1 
ATOM   1546 C CG  . TRP A 1 302 ? 130.539 142.917 154.836 1.00 56.51  ? 302 TRP A CG  1 
ATOM   1547 C CD1 . TRP A 1 302 ? 130.173 142.040 153.862 1.00 56.51  ? 302 TRP A CD1 1 
ATOM   1548 C CD2 . TRP A 1 302 ? 131.749 143.539 154.381 1.00 56.51  ? 302 TRP A CD2 1 
ATOM   1549 N NE1 . TRP A 1 302 ? 131.069 142.083 152.823 1.00 56.51  ? 302 TRP A NE1 1 
ATOM   1550 C CE2 . TRP A 1 302 ? 132.048 142.994 153.118 1.00 56.51  ? 302 TRP A CE2 1 
ATOM   1551 C CE3 . TRP A 1 302 ? 132.605 144.507 154.916 1.00 56.51  ? 302 TRP A CE3 1 
ATOM   1552 C CZ2 . TRP A 1 302 ? 133.164 143.383 152.383 1.00 56.51  ? 302 TRP A CZ2 1 
ATOM   1553 C CZ3 . TRP A 1 302 ? 133.713 144.889 154.184 1.00 56.51  ? 302 TRP A CZ3 1 
ATOM   1554 C CH2 . TRP A 1 302 ? 133.981 144.330 152.932 1.00 56.51  ? 302 TRP A CH2 1 
ATOM   1555 N N   . ALA A 1 303 ? 131.876 143.945 158.333 1.00 56.33  ? 303 ALA A N   1 
ATOM   1556 C CA  . ALA A 1 303 ? 133.181 144.504 158.671 1.00 56.33  ? 303 ALA A CA  1 
ATOM   1557 C C   . ALA A 1 303 ? 133.965 143.568 159.583 1.00 56.33  ? 303 ALA A C   1 
ATOM   1558 O O   . ALA A 1 303 ? 135.159 143.332 159.375 1.00 56.33  ? 303 ALA A O   1 
ATOM   1559 C CB  . ALA A 1 303 ? 133.004 145.873 159.326 1.00 56.33  ? 303 ALA A CB  1 
ATOM   1560 N N   . LEU A 1 304 ? 133.301 143.006 160.590 1.00 53.13  ? 304 LEU A N   1 
ATOM   1561 C CA  . LEU A 1 304 ? 134.004 142.211 161.587 1.00 53.13  ? 304 LEU A CA  1 
ATOM   1562 C C   . LEU A 1 304 ? 134.379 140.838 161.027 1.00 53.13  ? 304 LEU A C   1 
ATOM   1563 O O   . LEU A 1 304 ? 135.461 140.312 161.321 1.00 53.13  ? 304 LEU A O   1 
ATOM   1564 C CB  . LEU A 1 304 ? 133.139 142.117 162.847 1.00 53.13  ? 304 LEU A CB  1 
ATOM   1565 C CG  . LEU A 1 304 ? 133.648 141.410 164.097 1.00 53.13  ? 304 LEU A CG  1 
ATOM   1566 C CD1 . LEU A 1 304 ? 134.862 142.161 164.581 1.00 53.13  ? 304 LEU A CD1 1 
ATOM   1567 C CD2 . LEU A 1 304 ? 132.590 141.429 165.178 1.00 53.13  ? 304 LEU A CD2 1 
ATOM   1568 N N   . SER A 1 305 ? 133.512 140.250 160.195 1.00 51.70  ? 305 SER A N   1 
ATOM   1569 C CA  . SER A 1 305 ? 133.875 139.021 159.497 1.00 51.70  ? 305 SER A CA  1 
ATOM   1570 C C   . SER A 1 305 ? 135.028 139.252 158.525 1.00 51.70  ? 305 SER A C   1 
ATOM   1571 O O   . SER A 1 305 ? 135.911 138.396 158.386 1.00 51.70  ? 305 SER A O   1 
ATOM   1572 C CB  . SER A 1 305 ? 132.654 138.463 158.771 1.00 51.70  ? 305 SER A CB  1 
ATOM   1573 O OG  . SER A 1 305 ? 132.242 139.337 157.736 1.00 51.70  ? 305 SER A OG  1 
ATOM   1574 N N   . THR A 1 306 ? 135.036 140.399 157.836 1.00 50.73  ? 306 THR A N   1 
ATOM   1575 C CA  . THR A 1 306 ? 136.165 140.736 156.976 1.00 50.73  ? 306 THR A CA  1 
ATOM   1576 C C   . THR A 1 306 ? 137.444 140.878 157.788 1.00 50.73  ? 306 THR A C   1 
ATOM   1577 O O   . THR A 1 306 ? 138.517 140.450 157.348 1.00 50.73  ? 306 THR A O   1 
ATOM   1578 C CB  . THR A 1 306 ? 135.875 142.026 156.209 1.00 50.73  ? 306 THR A CB  1 
ATOM   1579 O OG1 . THR A 1 306 ? 134.535 141.992 155.704 1.00 50.73  ? 306 THR A OG1 1 
ATOM   1580 C CG2 . THR A 1 306 ? 136.839 142.181 155.050 1.00 50.73  ? 306 THR A CG2 1 
ATOM   1581 N N   . CYS A 1 307 ? 137.342 141.492 158.969 1.00 49.26  ? 307 CYS A N   1 
ATOM   1582 C CA  . CYS A 1 307 ? 138.461 141.555 159.904 1.00 49.26  ? 307 CYS A CA  1 
ATOM   1583 C C   . CYS A 1 307 ? 139.010 140.170 160.212 1.00 49.26  ? 307 CYS A C   1 
ATOM   1584 O O   . CYS A 1 307 ? 140.221 139.924 160.106 1.00 49.26  ? 307 CYS A O   1 
ATOM   1585 C CB  . CYS A 1 307 ? 137.998 142.235 161.191 1.00 49.26  ? 307 CYS A CB  1 
ATOM   1586 S SG  . CYS A 1 307 ? 139.245 142.377 162.466 1.00 49.26  ? 307 CYS A SG  1 
ATOM   1587 N N   . GLY A 1 308 ? 138.124 139.253 160.600 1.00 48.27  ? 308 GLY A N   1 
ATOM   1588 C CA  . GLY A 1 308 ? 138.569 137.911 160.939 1.00 48.27  ? 308 GLY A CA  1 
ATOM   1589 C C   . GLY A 1 308 ? 139.232 137.211 159.772 1.00 48.27  ? 308 GLY A C   1 
ATOM   1590 O O   . GLY A 1 308 ? 140.313 136.634 159.911 1.00 48.27  ? 308 GLY A O   1 
ATOM   1591 N N   . TYR A 1 309 ? 138.598 137.276 158.600 1.00 45.92  ? 309 TYR A N   1 
ATOM   1592 C CA  . TYR A 1 309 ? 139.171 136.694 157.390 1.00 45.92  ? 309 TYR A CA  1 
ATOM   1593 C C   . TYR A 1 309 ? 140.561 137.243 157.110 1.00 45.92  ? 309 TYR A C   1 
ATOM   1594 O O   . TYR A 1 309 ? 141.515 136.479 156.909 1.00 45.92  ? 309 TYR A O   1 
ATOM   1595 C CB  . TYR A 1 309 ? 138.250 136.985 156.211 1.00 45.92  ? 309 TYR A CB  1 
ATOM   1596 C CG  . TYR A 1 309 ? 138.770 136.561 154.859 1.00 45.92  ? 309 TYR A CG  1 
ATOM   1597 C CD1 . TYR A 1 309 ? 138.812 135.225 154.487 1.00 45.92  ? 309 TYR A CD1 1 
ATOM   1598 C CD2 . TYR A 1 309 ? 139.214 137.511 153.948 1.00 45.92  ? 309 TYR A CD2 1 
ATOM   1599 C CE1 . TYR A 1 309 ? 139.273 134.850 153.240 1.00 45.92  ? 309 TYR A CE1 1 
ATOM   1600 C CE2 . TYR A 1 309 ? 139.683 137.148 152.711 1.00 45.92  ? 309 TYR A CE2 1 
ATOM   1601 C CZ  . TYR A 1 309 ? 139.714 135.818 152.361 1.00 45.92  ? 309 TYR A CZ  1 
ATOM   1602 O OH  . TYR A 1 309 ? 140.186 135.467 151.119 1.00 45.92  ? 309 TYR A OH  1 
ATOM   1603 N N   . PHE A 1 310 ? 140.687 138.573 157.091 1.00 43.63  ? 310 PHE A N   1 
ATOM   1604 C CA  . PHE A 1 310 ? 141.954 139.201 156.740 1.00 43.63  ? 310 PHE A CA  1 
ATOM   1605 C C   . PHE A 1 310 ? 143.045 138.808 157.715 1.00 43.63  ? 310 PHE A C   1 
ATOM   1606 O O   . PHE A 1 310 ? 144.190 138.570 157.314 1.00 43.63  ? 310 PHE A O   1 
ATOM   1607 C CB  . PHE A 1 310 ? 141.801 140.720 156.707 1.00 43.63  ? 310 PHE A CB  1 
ATOM   1608 C CG  . PHE A 1 310 ? 141.211 141.246 155.436 1.00 43.63  ? 310 PHE A CG  1 
ATOM   1609 C CD1 . PHE A 1 310 ? 141.151 140.454 154.303 1.00 43.63  ? 310 PHE A CD1 1 
ATOM   1610 C CD2 . PHE A 1 310 ? 140.729 142.541 155.370 1.00 43.63  ? 310 PHE A CD2 1 
ATOM   1611 C CE1 . PHE A 1 310 ? 140.613 140.940 153.133 1.00 43.63  ? 310 PHE A CE1 1 
ATOM   1612 C CE2 . PHE A 1 310 ? 140.191 143.034 154.204 1.00 43.63  ? 310 PHE A CE2 1 
ATOM   1613 C CZ  . PHE A 1 310 ? 140.132 142.233 153.082 1.00 43.63  ? 310 PHE A CZ  1 
ATOM   1614 N N   . GLN A 1 311 ? 142.716 138.729 158.999 1.00 45.52  ? 311 GLN A N   1 
ATOM   1615 C CA  . GLN A 1 311 ? 143.764 138.458 159.964 1.00 45.52  ? 311 GLN A CA  1 
ATOM   1616 C C   . GLN A 1 311 ? 144.054 136.972 160.131 1.00 45.52  ? 311 GLN A C   1 
ATOM   1617 O O   . GLN A 1 311 ? 145.084 136.625 160.712 1.00 45.52  ? 311 GLN A O   1 
ATOM   1618 C CB  . GLN A 1 311 ? 143.411 139.085 161.312 1.00 45.52  ? 311 GLN A CB  1 
ATOM   1619 C CG  . GLN A 1 311 ? 144.611 139.295 162.207 1.00 45.52  ? 311 GLN A CG  1 
ATOM   1620 C CD  . GLN A 1 311 ? 144.231 139.426 163.650 1.00 45.52  ? 311 GLN A CD  1 
ATOM   1621 O OE1 . GLN A 1 311 ? 143.128 139.865 163.968 1.00 45.52  ? 311 GLN A OE1 1 
ATOM   1622 N NE2 . GLN A 1 311 ? 145.152 139.082 164.539 1.00 45.52  ? 311 GLN A NE2 1 
ATOM   1623 N N   . VAL A 1 312 ? 143.199 136.081 159.634 1.00 44.63  ? 312 VAL A N   1 
ATOM   1624 C CA  . VAL A 1 312 ? 143.530 134.662 159.755 1.00 44.63  ? 312 VAL A CA  1 
ATOM   1625 C C   . VAL A 1 312 ? 144.161 134.111 158.480 1.00 44.63  ? 312 VAL A C   1 
ATOM   1626 O O   . VAL A 1 312 ? 144.928 133.148 158.544 1.00 44.63  ? 312 VAL A O   1 
ATOM   1627 C CB  . VAL A 1 312 ? 142.298 133.832 160.167 1.00 44.63  ? 312 VAL A CB  1 
ATOM   1628 C CG1 . VAL A 1 312 ? 141.770 134.279 161.525 1.00 44.63  ? 312 VAL A CG1 1 
ATOM   1629 C CG2 . VAL A 1 312 ? 141.242 133.883 159.104 1.00 44.63  ? 312 VAL A CG2 1 
ATOM   1630 N N   . VAL A 1 313 ? 143.868 134.684 157.304 1.00 42.84  ? 313 VAL A N   1 
ATOM   1631 C CA  . VAL A 1 313 ? 144.365 134.090 156.057 1.00 42.84  ? 313 VAL A CA  1 
ATOM   1632 C C   . VAL A 1 313 ? 145.890 134.090 156.022 1.00 42.84  ? 313 VAL A C   1 
ATOM   1633 O O   . VAL A 1 313 ? 146.525 133.104 155.631 1.00 42.84  ? 313 VAL A O   1 
ATOM   1634 C CB  . VAL A 1 313 ? 143.786 134.813 154.828 1.00 42.84  ? 313 VAL A CB  1 
ATOM   1635 C CG1 . VAL A 1 313 ? 142.345 134.423 154.627 1.00 42.84  ? 313 VAL A CG1 1 
ATOM   1636 C CG2 . VAL A 1 313 ? 143.936 136.326 154.944 1.00 42.84  ? 313 VAL A CG2 1 
ATOM   1637 N N   . ASN A 1 314 ? 146.499 135.204 156.426 1.00 43.80  ? 314 ASN A N   1 
ATOM   1638 C CA  . ASN A 1 314 ? 147.944 135.348 156.298 1.00 43.80  ? 314 ASN A CA  1 
ATOM   1639 C C   . ASN A 1 314 ? 148.701 134.565 157.370 1.00 43.80  ? 314 ASN A C   1 
ATOM   1640 O O   . ASN A 1 314 ? 149.779 134.025 157.101 1.00 43.80  ? 314 ASN A O   1 
ATOM   1641 C CB  . ASN A 1 314 ? 148.312 136.833 156.298 1.00 43.80  ? 314 ASN A CB  1 
ATOM   1642 C CG  . ASN A 1 314 ? 147.804 137.557 157.515 1.00 43.80  ? 314 ASN A CG  1 
ATOM   1643 O OD1 . ASN A 1 314 ? 147.234 136.947 158.414 1.00 43.80  ? 314 ASN A OD1 1 
ATOM   1644 N ND2 . ASN A 1 314 ? 148.007 138.867 157.554 1.00 43.80  ? 314 ASN A ND2 1 
ATOM   1645 N N   . TYR A 1 315 ? 148.163 134.484 158.589 1.00 41.56  ? 315 TYR A N   1 
ATOM   1646 C CA  . TYR A 1 315 ? 148.841 133.674 159.599 1.00 41.56  ? 315 TYR A CA  1 
ATOM   1647 C C   . TYR A 1 315 ? 148.487 132.197 159.467 1.00 41.56  ? 315 TYR A C   1 
ATOM   1648 O O   . TYR A 1 315 ? 149.090 131.352 160.141 1.00 41.56  ? 315 TYR A O   1 
ATOM   1649 C CB  . TYR A 1 315 ? 148.536 134.189 161.006 1.00 41.56  ? 315 TYR A CB  1 
ATOM   1650 C CG  . TYR A 1 315 ? 148.966 135.622 161.214 1.00 41.56  ? 315 TYR A CG  1 
ATOM   1651 C CD1 . TYR A 1 315 ? 150.299 135.947 161.414 1.00 41.56  ? 315 TYR A CD1 1 
ATOM   1652 C CD2 . TYR A 1 315 ? 148.038 136.647 161.236 1.00 41.56  ? 315 TYR A CD2 1 
ATOM   1653 C CE1 . TYR A 1 315 ? 150.693 137.258 161.600 1.00 41.56  ? 315 TYR A CE1 1 
ATOM   1654 C CE2 . TYR A 1 315 ? 148.421 137.958 161.419 1.00 41.56  ? 315 TYR A CE2 1 
ATOM   1655 C CZ  . TYR A 1 315 ? 149.746 138.258 161.603 1.00 41.56  ? 315 TYR A CZ  1 
ATOM   1656 O OH  . TYR A 1 315 ? 150.121 139.565 161.791 1.00 41.56  ? 315 TYR A OH  1 
ATOM   1657 N N   . THR A 1 316 ? 147.533 131.858 158.598 1.00 42.60  ? 316 THR A N   1 
ATOM   1658 C CA  . THR A 1 316 ? 147.307 130.454 158.283 1.00 42.60  ? 316 THR A CA  1 
ATOM   1659 C C   . THR A 1 316 ? 148.511 129.853 157.566 1.00 42.60  ? 316 THR A C   1 
ATOM   1660 O O   . THR A 1 316 ? 148.818 128.666 157.745 1.00 42.60  ? 316 THR A O   1 
ATOM   1661 C CB  . THR A 1 316 ? 146.045 130.316 157.438 1.00 42.60  ? 316 THR A CB  1 
ATOM   1662 O OG1 . THR A 1 316 ? 144.958 130.961 158.110 1.00 42.60  ? 316 THR A OG1 1 
ATOM   1663 C CG2 . THR A 1 316 ? 145.692 128.861 157.266 1.00 42.60  ? 316 THR A CG2 1 
ATOM   1664 N N   . GLN A 1 317 ? 149.213 130.663 156.767 1.00 39.58  ? 317 GLN A N   1 
ATOM   1665 C CA  . GLN A 1 317 ? 150.486 130.234 156.198 1.00 39.58  ? 317 GLN A CA  1 
ATOM   1666 C C   . GLN A 1 317 ? 151.460 129.837 157.296 1.00 39.58  ? 317 GLN A C   1 
ATOM   1667 O O   . GLN A 1 317 ? 152.123 128.795 157.211 1.00 39.58  ? 317 GLN A O   1 
ATOM   1668 C CB  . GLN A 1 317 ? 151.087 131.365 155.363 1.00 39.58  ? 317 GLN A CB  1 
ATOM   1669 C CG  . GLN A 1 317 ? 150.308 131.763 154.127 1.00 39.58  ? 317 GLN A CG  1 
ATOM   1670 C CD  . GLN A 1 317 ? 150.203 130.647 153.122 1.00 39.58  ? 317 GLN A CD  1 
ATOM   1671 O OE1 . GLN A 1 317 ? 149.133 130.079 152.920 1.00 39.58  ? 317 GLN A OE1 1 
ATOM   1672 N NE2 . GLN A 1 317 ? 151.316 130.328 152.474 1.00 39.58  ? 317 GLN A NE2 1 
ATOM   1673 N N   . GLY A 1 318 ? 151.552 130.657 158.342 1.00 42.58  ? 318 GLY A N   1 
ATOM   1674 C CA  . GLY A 1 318 ? 152.448 130.344 159.438 1.00 42.58  ? 318 GLY A CA  1 
ATOM   1675 C C   . GLY A 1 318 ? 152.023 129.113 160.210 1.00 42.58  ? 318 GLY A C   1 
ATOM   1676 O O   . GLY A 1 318 ? 152.864 128.345 160.679 1.00 42.58  ? 318 GLY A O   1 
ATOM   1677 N N   . LEU A 1 319 ? 150.713 128.919 160.373 1.00 42.83  ? 319 LEU A N   1 
ATOM   1678 C CA  . LEU A 1 319 ? 150.244 127.700 161.025 1.00 42.83  ? 319 LEU A CA  1 
ATOM   1679 C C   . LEU A 1 319 ? 150.634 126.467 160.219 1.00 42.83  ? 319 LEU A C   1 
ATOM   1680 O O   . LEU A 1 319 ? 151.089 125.467 160.788 1.00 42.83  ? 319 LEU A O   1 
ATOM   1681 C CB  . LEU A 1 319 ? 148.730 127.749 161.246 1.00 42.83  ? 319 LEU A CB  1 
ATOM   1682 C CG  . LEU A 1 319 ? 148.103 126.621 162.081 1.00 42.83  ? 319 LEU A CG  1 
ATOM   1683 C CD1 . LEU A 1 319 ? 146.841 127.110 162.746 1.00 42.83  ? 319 LEU A CD1 1 
ATOM   1684 C CD2 . LEU A 1 319 ? 147.767 125.378 161.256 1.00 42.83  ? 319 LEU A CD2 1 
ATOM   1685 N N   . TRP A 1 320 ? 150.458 126.513 158.895 1.00 42.12  ? 320 TRP A N   1 
ATOM   1686 C CA  . TRP A 1 320 ? 150.868 125.378 158.069 1.00 42.12  ? 320 TRP A CA  1 
ATOM   1687 C C   . TRP A 1 320 ? 152.371 125.147 158.152 1.00 42.12  ? 320 TRP A C   1 
ATOM   1688 O O   . TRP A 1 320 ? 152.828 123.998 158.169 1.00 42.12  ? 320 TRP A O   1 
ATOM   1689 C CB  . TRP A 1 320 ? 150.442 125.574 156.614 1.00 42.12  ? 320 TRP A CB  1 
ATOM   1690 C CG  . TRP A 1 320 ? 148.974 125.739 156.409 1.00 42.12  ? 320 TRP A CG  1 
ATOM   1691 C CD1 . TRP A 1 320 ? 147.979 125.335 157.246 1.00 42.12  ? 320 TRP A CD1 1 
ATOM   1692 C CD2 . TRP A 1 320 ? 148.330 126.304 155.263 1.00 42.12  ? 320 TRP A CD2 1 
ATOM   1693 N NE1 . TRP A 1 320 ? 146.754 125.638 156.705 1.00 42.12  ? 320 TRP A NE1 1 
ATOM   1694 C CE2 . TRP A 1 320 ? 146.943 126.231 155.486 1.00 42.12  ? 320 TRP A CE2 1 
ATOM   1695 C CE3 . TRP A 1 320 ? 148.791 126.875 154.077 1.00 42.12  ? 320 TRP A CE3 1 
ATOM   1696 C CZ2 . TRP A 1 320 ? 146.015 126.708 154.565 1.00 42.12  ? 320 TRP A CZ2 1 
ATOM   1697 C CZ3 . TRP A 1 320 ? 147.870 127.345 153.165 1.00 42.12  ? 320 TRP A CZ3 1 
ATOM   1698 C CH2 . TRP A 1 320 ? 146.498 127.264 153.414 1.00 42.12  ? 320 TRP A CH2 1 
ATOM   1699 N N   . GLU A 1 321 ? 153.156 126.225 158.191 1.00 46.14  ? 321 GLU A N   1 
ATOM   1700 C CA  . GLU A 1 321 ? 154.601 126.075 158.339 1.00 46.14  ? 321 GLU A CA  1 
ATOM   1701 C C   . GLU A 1 321 ? 154.956 125.442 159.680 1.00 46.14  ? 321 GLU A C   1 
ATOM   1702 O O   . GLU A 1 321 ? 155.845 124.585 159.755 1.00 46.14  ? 321 GLU A O   1 
ATOM   1703 C CB  . GLU A 1 321 ? 155.287 127.433 158.179 1.00 46.14  ? 321 GLU A CB  1 
ATOM   1704 C CG  . GLU A 1 321 ? 156.692 127.514 158.762 1.00 46.14  ? 321 GLU A CG  1 
ATOM   1705 C CD  . GLU A 1 321 ? 157.652 126.518 158.140 1.00 46.14  ? 321 GLU A CD  1 
ATOM   1706 O OE1 . GLU A 1 321 ? 157.496 126.196 156.943 1.00 46.14  ? 321 GLU A OE1 1 
ATOM   1707 O OE2 . GLU A 1 321 ? 158.570 126.058 158.851 1.00 46.14  ? 321 GLU A OE2 1 
ATOM   1708 N N   . LYS A 1 322 ? 154.271 125.852 160.749 1.00 43.07  ? 322 LYS A N   1 
ATOM   1709 C CA  . LYS A 1 322 ? 154.542 125.297 162.071 1.00 43.07  ? 322 LYS A CA  1 
ATOM   1710 C C   . LYS A 1 322 ? 154.184 123.818 162.137 1.00 43.07  ? 322 LYS A C   1 
ATOM   1711 O O   . LYS A 1 322 ? 154.942 123.014 162.691 1.00 43.07  ? 322 LYS A O   1 
ATOM   1712 C CB  . LYS A 1 322 ? 153.776 126.086 163.132 1.00 43.07  ? 322 LYS A CB  1 
ATOM   1713 C CG  . LYS A 1 322 ? 154.076 125.669 164.562 1.00 43.07  ? 322 LYS A CG  1 
ATOM   1714 C CD  . LYS A 1 322 ? 152.883 124.973 165.195 1.00 43.07  ? 322 LYS A CD  1 
ATOM   1715 C CE  . LYS A 1 322 ? 152.960 125.020 166.712 1.00 43.07  ? 322 LYS A CE  1 
ATOM   1716 N NZ  . LYS A 1 322 ? 151.835 124.284 167.349 1.00 43.07  ? 322 LYS A NZ  1 
ATOM   1717 N N   . VAL A 1 323 ? 153.031 123.439 161.582 1.00 44.07  ? 323 VAL A N   1 
ATOM   1718 C CA  . VAL A 1 323 ? 152.625 122.037 161.606 1.00 44.07  ? 323 VAL A CA  1 
ATOM   1719 C C   . VAL A 1 323 ? 153.550 121.199 160.731 1.00 44.07  ? 323 VAL A C   1 
ATOM   1720 O O   . VAL A 1 323 ? 154.029 120.137 161.143 1.00 44.07  ? 323 VAL A O   1 
ATOM   1721 C CB  . VAL A 1 323 ? 151.155 121.892 161.174 1.00 44.07  ? 323 VAL A CB  1 
ATOM   1722 C CG1 . VAL A 1 323 ? 150.758 120.428 161.146 1.00 44.07  ? 323 VAL A CG1 1 
ATOM   1723 C CG2 . VAL A 1 323 ? 150.249 122.663 162.114 1.00 44.07  ? 323 VAL A CG2 1 
ATOM   1724 N N   . MET A 1 324 ? 153.816 121.665 159.514 1.00 45.36  ? 324 MET A N   1 
ATOM   1725 C CA  . MET A 1 324 ? 154.713 120.978 158.584 1.00 45.36  ? 324 MET A CA  1 
ATOM   1726 C C   . MET A 1 324 ? 155.851 121.910 158.195 1.00 45.36  ? 324 MET A C   1 
ATOM   1727 O O   . MET A 1 324 ? 155.651 122.833 157.386 1.00 45.36  ? 324 MET A O   1 
ATOM   1728 C CB  . MET A 1 324 ? 153.956 120.508 157.344 1.00 45.36  ? 324 MET A CB  1 
ATOM   1729 N N   . PRO A 1 325 ? 157.050 121.725 158.743 1.00 44.42  ? 325 PRO A N   1 
ATOM   1730 C CA  . PRO A 1 325 ? 158.168 122.597 158.371 1.00 44.42  ? 325 PRO A CA  1 
ATOM   1731 C C   . PRO A 1 325 ? 158.579 122.388 156.923 1.00 44.42  ? 325 PRO A C   1 
ATOM   1732 O O   . PRO A 1 325 ? 158.470 121.291 156.370 1.00 44.42  ? 325 PRO A O   1 
ATOM   1733 C CB  . PRO A 1 325 ? 159.285 122.179 159.334 1.00 44.42  ? 325 PRO A CB  1 
ATOM   1734 C CG  . PRO A 1 325 ? 158.952 120.783 159.726 1.00 44.42  ? 325 PRO A CG  1 
ATOM   1735 C CD  . PRO A 1 325 ? 157.458 120.635 159.647 1.00 44.42  ? 325 PRO A CD  1 
ATOM   1736 N N   . SER A 1 326 ? 159.061 123.465 156.310 1.00 41.57  ? 326 SER A N   1 
ATOM   1737 C CA  . SER A 1 326 ? 159.470 123.450 154.913 1.00 41.57  ? 326 SER A CA  1 
ATOM   1738 C C   . SER A 1 326 ? 160.944 123.114 154.727 1.00 41.57  ? 326 SER A C   1 
ATOM   1739 O O   . SER A 1 326 ? 161.431 123.149 153.593 1.00 41.57  ? 326 SER A O   1 
ATOM   1740 C CB  . SER A 1 326 ? 159.168 124.804 154.264 1.00 41.57  ? 326 SER A CB  1 
ATOM   1741 O OG  . SER A 1 326 ? 160.167 125.754 154.586 1.00 41.57  ? 326 SER A OG  1 
ATOM   1742 N N   . ARG A 1 327 ? 161.663 122.802 155.809 1.00 43.51  ? 327 ARG A N   1 
ATOM   1743 C CA  . ARG A 1 327 ? 163.095 122.542 155.700 1.00 43.51  ? 327 ARG A CA  1 
ATOM   1744 C C   . ARG A 1 327 ? 163.377 121.291 154.877 1.00 43.51  ? 327 ARG A C   1 
ATOM   1745 O O   . ARG A 1 327 ? 164.276 121.288 154.028 1.00 43.51  ? 327 ARG A O   1 
ATOM   1746 C CB  . ARG A 1 327 ? 163.711 122.414 157.093 1.00 43.51  ? 327 ARG A CB  1 
ATOM   1747 N N   . TYR A 1 328 ? 162.618 120.215 155.110 1.00 46.11  ? 328 TYR A N   1 
ATOM   1748 C CA  . TYR A 1 328 ? 162.861 118.964 154.402 1.00 46.11  ? 328 TYR A CA  1 
ATOM   1749 C C   . TYR A 1 328 ? 161.570 118.274 153.974 1.00 46.11  ? 328 TYR A C   1 
ATOM   1750 O O   . TYR A 1 328 ? 161.576 117.059 153.745 1.00 46.11  ? 328 TYR A O   1 
ATOM   1751 C CB  . TYR A 1 328 ? 163.691 118.006 155.264 1.00 46.11  ? 328 TYR A CB  1 
ATOM   1752 N N   . ALA A 1 329 ? 160.467 119.009 153.861 1.00 45.61  ? 329 ALA A N   1 
ATOM   1753 C CA  . ALA A 1 329 ? 159.186 118.438 153.476 1.00 45.61  ? 329 ALA A CA  1 
ATOM   1754 C C   . ALA A 1 329 ? 158.542 119.294 152.395 1.00 45.61  ? 329 ALA A C   1 
ATOM   1755 O O   . ALA A 1 329 ? 158.667 120.521 152.393 1.00 45.61  ? 329 ALA A O   1 
ATOM   1756 C CB  . ALA A 1 329 ? 158.242 118.315 154.678 1.00 45.61  ? 329 ALA A CB  1 
ATOM   1757 N N   . ALA A 1 330 ? 157.845 118.630 151.477 1.00 45.34  ? 330 ALA A N   1 
ATOM   1758 C CA  . ALA A 1 330 ? 157.149 119.307 150.392 1.00 45.34  ? 330 ALA A CA  1 
ATOM   1759 C C   . ALA A 1 330 ? 155.786 119.778 150.877 1.00 45.34  ? 330 ALA A C   1 
ATOM   1760 O O   . ALA A 1 330 ? 155.014 118.992 151.435 1.00 45.34  ? 330 ALA A O   1 
ATOM   1761 C CB  . ALA A 1 330 ? 156.994 118.380 149.186 1.00 45.34  ? 330 ALA A CB  1 
ATOM   1762 N N   . ILE A 1 331 ? 155.493 121.057 150.661 1.00 41.34  ? 331 ILE A N   1 
ATOM   1763 C CA  . ILE A 1 331 ? 154.272 121.687 151.147 1.00 41.34  ? 331 ILE A CA  1 
ATOM   1764 C C   . ILE A 1 331 ? 153.360 121.981 149.961 1.00 41.34  ? 331 ILE A C   1 
ATOM   1765 O O   . ILE A 1 331 ? 153.789 122.572 148.963 1.00 41.34  ? 331 ILE A O   1 
ATOM   1766 C CB  . ILE A 1 331 ? 154.588 122.949 151.974 1.00 41.34  ? 331 ILE A CB  1 
ATOM   1767 C CG1 . ILE A 1 331 ? 153.331 123.458 152.682 1.00 41.34  ? 331 ILE A CG1 1 
ATOM   1768 C CG2 . ILE A 1 331 ? 155.308 124.020 151.150 1.00 41.34  ? 331 ILE A CG2 1 
ATOM   1769 C CD1 . ILE A 1 331 ? 153.606 124.485 153.754 1.00 41.34  ? 331 ILE A CD1 1 
ATOM   1770 N N   . TYR A 1 332 ? 152.119 121.515 150.050 1.00 43.26  ? 332 TYR A N   1 
ATOM   1771 C CA  . TYR A 1 332 ? 151.163 121.609 148.945 1.00 43.26  ? 332 TYR A CA  1 
ATOM   1772 C C   . TYR A 1 332 ? 150.177 122.758 149.164 1.00 43.26  ? 332 TYR A C   1 
ATOM   1773 O O   . TYR A 1 332 ? 148.974 122.555 149.331 1.00 43.26  ? 332 TYR A O   1 
ATOM   1774 C CB  . TYR A 1 332 ? 150.434 120.279 148.769 1.00 43.26  ? 332 TYR A CB  1 
ATOM   1775 C CG  . TYR A 1 332 ? 151.359 119.084 148.671 1.00 43.26  ? 332 TYR A CG  1 
ATOM   1776 C CD1 . TYR A 1 332 ? 151.728 118.371 149.805 1.00 43.26  ? 332 TYR A CD1 1 
ATOM   1777 C CD2 . TYR A 1 332 ? 151.868 118.673 147.447 1.00 43.26  ? 332 TYR A CD2 1 
ATOM   1778 C CE1 . TYR A 1 332 ? 152.575 117.281 149.720 1.00 43.26  ? 332 TYR A CE1 1 
ATOM   1779 C CE2 . TYR A 1 332 ? 152.716 117.584 147.353 1.00 43.26  ? 332 TYR A CE2 1 
ATOM   1780 C CZ  . TYR A 1 332 ? 153.065 116.893 148.493 1.00 43.26  ? 332 TYR A CZ  1 
ATOM   1781 O OH  . TYR A 1 332 ? 153.907 115.809 148.405 1.00 43.26  ? 332 TYR A OH  1 
ATOM   1782 N N   . ASN A 1 333 ? 150.700 123.987 149.157 1.00 40.20  ? 333 ASN A N   1 
ATOM   1783 C CA  . ASN A 1 333 ? 149.826 125.147 149.311 1.00 40.20  ? 333 ASN A CA  1 
ATOM   1784 C C   . ASN A 1 333 ? 148.994 125.399 148.061 1.00 40.20  ? 333 ASN A C   1 
ATOM   1785 O O   . ASN A 1 333 ? 147.784 125.639 148.163 1.00 40.20  ? 333 ASN A O   1 
ATOM   1786 C CB  . ASN A 1 333 ? 150.644 126.397 149.632 1.00 40.20  ? 333 ASN A CB  1 
ATOM   1787 C CG  . ASN A 1 333 ? 151.580 126.200 150.799 1.00 40.20  ? 333 ASN A CG  1 
ATOM   1788 O OD1 . ASN A 1 333 ? 152.712 125.761 150.624 1.00 40.20  ? 333 ASN A OD1 1 
ATOM   1789 N ND2 . ASN A 1 333 ? 151.120 126.536 151.994 1.00 40.20  ? 333 ASN A ND2 1 
ATOM   1790 N N   . GLY A 1 334 ? 149.621 125.320 146.883 1.00 42.56  ? 334 GLY A N   1 
ATOM   1791 C CA  . GLY A 1 334 ? 148.995 125.822 145.669 1.00 42.56  ? 334 GLY A CA  1 
ATOM   1792 C C   . GLY A 1 334 ? 147.652 125.187 145.372 1.00 42.56  ? 334 GLY A C   1 
ATOM   1793 O O   . GLY A 1 334 ? 146.694 125.882 145.018 1.00 42.56  ? 334 GLY A O   1 
ATOM   1794 N N   . GLY A 1 335 ? 147.553 123.868 145.530 1.00 44.92  ? 335 GLY A N   1 
ATOM   1795 C CA  . GLY A 1 335 ? 146.269 123.216 145.344 1.00 44.92  ? 335 GLY A CA  1 
ATOM   1796 C C   . GLY A 1 335 ? 145.215 123.742 146.297 1.00 44.92  ? 335 GLY A C   1 
ATOM   1797 O O   . GLY A 1 335 ? 144.042 123.866 145.936 1.00 44.92  ? 335 GLY A O   1 
ATOM   1798 N N   . VAL A 1 336 ? 145.624 124.085 147.520 1.00 44.16  ? 336 VAL A N   1 
ATOM   1799 C CA  . VAL A 1 336 ? 144.666 124.533 148.526 1.00 44.16  ? 336 VAL A CA  1 
ATOM   1800 C C   . VAL A 1 336 ? 144.194 125.952 148.240 1.00 44.16  ? 336 VAL A C   1 
ATOM   1801 O O   . VAL A 1 336 ? 142.992 126.238 148.302 1.00 44.16  ? 336 VAL A O   1 
ATOM   1802 C CB  . VAL A 1 336 ? 145.279 124.397 149.928 1.00 44.16  ? 336 VAL A CB  1 
ATOM   1803 C CG1 . VAL A 1 336 ? 144.453 125.158 150.948 1.00 44.16  ? 336 VAL A CG1 1 
ATOM   1804 C CG2 . VAL A 1 336 ? 145.363 122.928 150.285 1.00 44.16  ? 336 VAL A CG2 1 
ATOM   1805 N N   . GLU A 1 337 ? 145.116 126.865 147.917 1.00 42.50  ? 337 GLU A N   1 
ATOM   1806 C CA  . GLU A 1 337 ? 144.673 128.206 147.538 1.00 42.50  ? 337 GLU A CA  1 
ATOM   1807 C C   . GLU A 1 337 ? 143.961 128.212 146.192 1.00 42.50  ? 337 GLU A C   1 
ATOM   1808 O O   . GLU A 1 337 ? 143.288 129.193 145.854 1.00 42.50  ? 337 GLU A O   1 
ATOM   1809 C CB  . GLU A 1 337 ? 145.830 129.207 147.525 1.00 42.50  ? 337 GLU A CB  1 
ATOM   1810 C CG  . GLU A 1 337 ? 146.259 129.692 148.902 1.00 42.50  ? 337 GLU A CG  1 
ATOM   1811 C CD  . GLU A 1 337 ? 147.458 128.962 149.446 1.00 42.50  ? 337 GLU A CD  1 
ATOM   1812 O OE1 . GLU A 1 337 ? 148.079 128.200 148.687 1.00 42.50  ? 337 GLU A OE1 1 
ATOM   1813 O OE2 . GLU A 1 337 ? 147.785 129.160 150.632 1.00 42.50  ? 337 GLU A OE2 1 
ATOM   1814 N N   . ALA A 1 338 ? 144.090 127.142 145.410 1.00 44.55  ? 338 ALA A N   1 
ATOM   1815 C CA  . ALA A 1 338 ? 143.278 127.017 144.208 1.00 44.55  ? 338 ALA A CA  1 
ATOM   1816 C C   . ALA A 1 338 ? 141.856 126.573 144.531 1.00 44.55  ? 338 ALA A C   1 
ATOM   1817 O O   . ALA A 1 338 ? 140.888 127.233 144.134 1.00 44.55  ? 338 ALA A O   1 
ATOM   1818 C CB  . ALA A 1 338 ? 143.932 126.032 143.236 1.00 44.55  ? 338 ALA A CB  1 
ATOM   1819 N N   . VAL A 1 339 ? 141.724 125.459 145.257 1.00 47.49  ? 339 VAL A N   1 
ATOM   1820 C CA  . VAL A 1 339 ? 140.412 124.896 145.553 1.00 47.49  ? 339 VAL A CA  1 
ATOM   1821 C C   . VAL A 1 339 ? 139.607 125.833 146.443 1.00 47.49  ? 339 VAL A C   1 
ATOM   1822 O O   . VAL A 1 339 ? 138.379 125.910 146.317 1.00 47.49  ? 339 VAL A O   1 
ATOM   1823 C CB  . VAL A 1 339 ? 140.559 123.490 146.172 1.00 47.49  ? 339 VAL A CB  1 
ATOM   1824 C CG1 . VAL A 1 339 ? 141.260 123.548 147.517 1.00 47.49  ? 339 VAL A CG1 1 
ATOM   1825 C CG2 . VAL A 1 339 ? 139.203 122.817 146.307 1.00 47.49  ? 339 VAL A CG2 1 
ATOM   1826 N N   . SER A 1 340 ? 140.271 126.575 147.335 1.00 46.56  ? 340 SER A N   1 
ATOM   1827 C CA  . SER A 1 340 ? 139.566 127.517 148.195 1.00 46.56  ? 340 SER A CA  1 
ATOM   1828 C C   . SER A 1 340 ? 138.884 128.603 147.375 1.00 46.56  ? 340 SER A C   1 
ATOM   1829 O O   . SER A 1 340 ? 137.688 128.863 147.542 1.00 46.56  ? 340 SER A O   1 
ATOM   1830 C CB  . SER A 1 340 ? 140.544 128.130 149.192 1.00 46.56  ? 340 SER A CB  1 
ATOM   1831 O OG  . SER A 1 340 ? 141.432 129.020 148.543 1.00 46.56  ? 340 SER A OG  1 
ATOM   1832 N N   . THR A 1 341 ? 139.628 129.233 146.463 1.00 48.13  ? 341 THR A N   1 
ATOM   1833 C CA  . THR A 1 341 ? 139.047 130.264 145.607 1.00 48.13  ? 341 THR A CA  1 
ATOM   1834 C C   . THR A 1 341 ? 137.986 129.683 144.680 1.00 48.13  ? 341 THR A C   1 
ATOM   1835 O O   . THR A 1 341 ? 136.951 130.318 144.434 1.00 48.13  ? 341 THR A O   1 
ATOM   1836 C CB  . THR A 1 341 ? 140.145 130.949 144.796 1.00 48.13  ? 341 THR A CB  1 
ATOM   1837 O OG1 . THR A 1 341 ? 140.904 129.960 144.092 1.00 48.13  ? 341 THR A OG1 1 
ATOM   1838 C CG2 . THR A 1 341 ? 141.072 131.729 145.711 1.00 48.13  ? 341 THR A CG2 1 
ATOM   1839 N N   . LEU A 1 342 ? 138.222 128.476 144.159 1.00 49.83  ? 342 LEU A N   1 
ATOM   1840 C CA  . LEU A 1 342 ? 137.265 127.866 143.240 1.00 49.83  ? 342 LEU A CA  1 
ATOM   1841 C C   . LEU A 1 342 ? 135.931 127.601 143.930 1.00 49.83  ? 342 LEU A C   1 
ATOM   1842 O O   . LEU A 1 342 ? 134.866 127.993 143.433 1.00 49.83  ? 342 LEU A O   1 
ATOM   1843 C CB  . LEU A 1 342 ? 137.854 126.573 142.673 1.00 49.83  ? 342 LEU A CB  1 
ATOM   1844 C CG  . LEU A 1 342 ? 137.266 126.023 141.374 1.00 49.83  ? 342 LEU A CG  1 
ATOM   1845 C CD1 . LEU A 1 342 ? 137.487 127.004 140.234 1.00 49.83  ? 342 LEU A CD1 1 
ATOM   1846 C CD2 . LEU A 1 342 ? 137.884 124.672 141.049 1.00 49.83  ? 342 LEU A CD2 1 
ATOM   1847 N N   . LEU A 1 343 ? 135.971 126.950 145.094 1.00 51.59  ? 343 LEU A N   1 
ATOM   1848 C CA  . LEU A 1 343 ? 134.740 126.681 145.826 1.00 51.59  ? 343 LEU A CA  1 
ATOM   1849 C C   . LEU A 1 343 ? 134.136 127.955 146.401 1.00 51.59  ? 343 LEU A C   1 
ATOM   1850 O O   . LEU A 1 343 ? 132.920 128.019 146.600 1.00 51.59  ? 343 LEU A O   1 
ATOM   1851 C CB  . LEU A 1 343 ? 134.990 125.656 146.930 1.00 51.59  ? 343 LEU A CB  1 
ATOM   1852 C CG  . LEU A 1 343 ? 134.817 124.180 146.560 1.00 51.59  ? 343 LEU A CG  1 
ATOM   1853 C CD1 . LEU A 1 343 ? 133.372 123.903 146.178 1.00 51.59  ? 343 LEU A CD1 1 
ATOM   1854 C CD2 . LEU A 1 343 ? 135.757 123.748 145.447 1.00 51.59  ? 343 LEU A CD2 1 
ATOM   1855 N N   . GLY A 1 344 ? 134.949 128.982 146.655 1.00 57.03  ? 344 GLY A N   1 
ATOM   1856 C CA  . GLY A 1 344 ? 134.388 130.266 147.037 1.00 57.03  ? 344 GLY A CA  1 
ATOM   1857 C C   . GLY A 1 344 ? 133.574 130.891 145.921 1.00 57.03  ? 344 GLY A C   1 
ATOM   1858 O O   . GLY A 1 344 ? 132.493 131.434 146.159 1.00 57.03  ? 344 GLY A O   1 
ATOM   1859 N N   . ALA A 1 345 ? 134.081 130.821 144.688 1.00 57.69  ? 345 ALA A N   1 
ATOM   1860 C CA  . ALA A 1 345 ? 133.306 131.288 143.541 1.00 57.69  ? 345 ALA A CA  1 
ATOM   1861 C C   . ALA A 1 345 ? 132.036 130.464 143.366 1.00 57.69  ? 345 ALA A C   1 
ATOM   1862 O O   . ALA A 1 345 ? 130.965 131.009 143.063 1.00 57.69  ? 345 ALA A O   1 
ATOM   1863 C CB  . ALA A 1 345 ? 134.160 131.237 142.275 1.00 57.69  ? 345 ALA A CB  1 
ATOM   1864 N N   . VAL A 1 346 ? 132.139 129.145 143.555 1.00 57.76  ? 346 VAL A N   1 
ATOM   1865 C CA  . VAL A 1 346 ? 130.964 128.281 143.457 1.00 57.76  ? 346 VAL A CA  1 
ATOM   1866 C C   . VAL A 1 346 ? 129.920 128.676 144.497 1.00 57.76  ? 346 VAL A C   1 
ATOM   1867 O O   . VAL A 1 346 ? 128.724 128.765 144.196 1.00 57.76  ? 346 VAL A O   1 
ATOM   1868 C CB  . VAL A 1 346 ? 131.375 126.804 143.598 1.00 57.76  ? 346 VAL A CB  1 
ATOM   1869 C CG1 . VAL A 1 346 ? 130.150 125.921 143.751 1.00 57.76  ? 346 VAL A CG1 1 
ATOM   1870 C CG2 . VAL A 1 346 ? 132.196 126.367 142.398 1.00 57.76  ? 346 VAL A CG2 1 
ATOM   1871 N N   . ALA A 1 347 ? 130.358 128.923 145.733 1.00 60.10  ? 347 ALA A N   1 
ATOM   1872 C CA  . ALA A 1 347 ? 129.441 129.328 146.792 1.00 60.10  ? 347 ALA A CA  1 
ATOM   1873 C C   . ALA A 1 347 ? 128.843 130.701 146.514 1.00 60.10  ? 347 ALA A C   1 
ATOM   1874 O O   . ALA A 1 347 ? 127.672 130.948 146.824 1.00 60.10  ? 347 ALA A O   1 
ATOM   1875 C CB  . ALA A 1 347 ? 130.162 129.320 148.139 1.00 60.10  ? 347 ALA A CB  1 
ATOM   1876 N N   . VAL A 1 348 ? 129.634 131.608 145.941 1.00 59.96  ? 348 VAL A N   1 
ATOM   1877 C CA  . VAL A 1 348 ? 129.115 132.920 145.566 1.00 59.96  ? 348 VAL A CA  1 
ATOM   1878 C C   . VAL A 1 348 ? 128.001 132.771 144.541 1.00 59.96  ? 348 VAL A C   1 
ATOM   1879 O O   . VAL A 1 348 ? 126.967 133.445 144.621 1.00 59.96  ? 348 VAL A O   1 
ATOM   1880 C CB  . VAL A 1 348 ? 130.254 133.812 145.040 1.00 59.96  ? 348 VAL A CB  1 
ATOM   1881 N N   . PHE A 1 349 ? 128.199 131.887 143.560 1.00 61.95  ? 349 PHE A N   1 
ATOM   1882 C CA  . PHE A 1 349 ? 127.151 131.625 142.577 1.00 61.95  ? 349 PHE A CA  1 
ATOM   1883 C C   . PHE A 1 349 ? 125.922 131.000 143.227 1.00 61.95  ? 349 PHE A C   1 
ATOM   1884 O O   . PHE A 1 349 ? 124.786 131.372 142.912 1.00 61.95  ? 349 PHE A O   1 
ATOM   1885 C CB  . PHE A 1 349 ? 127.688 130.720 141.468 1.00 61.95  ? 349 PHE A CB  1 
ATOM   1886 N N   . ALA A 1 350 ? 126.130 130.050 144.142 1.00 62.87  ? 350 ALA A N   1 
ATOM   1887 C CA  . ALA A 1 350 ? 125.017 129.324 144.743 1.00 62.87  ? 350 ALA A CA  1 
ATOM   1888 C C   . ALA A 1 350 ? 124.258 130.150 145.773 1.00 62.87  ? 350 ALA A C   1 
ATOM   1889 O O   . ALA A 1 350 ? 123.136 129.782 146.133 1.00 62.87  ? 350 ALA A O   1 
ATOM   1890 C CB  . ALA A 1 350 ? 125.519 128.032 145.389 1.00 62.87  ? 350 ALA A CB  1 
ATOM   1891 N N   . VAL A 1 351 ? 124.847 131.242 146.264 1.00 64.22  ? 351 VAL A N   1 
ATOM   1892 C CA  . VAL A 1 351 ? 124.178 132.053 147.279 1.00 64.22  ? 351 VAL A CA  1 
ATOM   1893 C C   . VAL A 1 351 ? 122.909 132.681 146.717 1.00 64.22  ? 351 VAL A C   1 
ATOM   1894 O O   . VAL A 1 351 ? 121.896 132.801 147.418 1.00 64.22  ? 351 VAL A O   1 
ATOM   1895 C CB  . VAL A 1 351 ? 125.141 133.121 147.828 1.00 64.22  ? 351 VAL A CB  1 
ATOM   1896 N N   . GLY A 1 352 ? 122.941 133.093 145.451 1.00 62.98  ? 352 GLY A N   1 
ATOM   1897 C CA  . GLY A 1 352 ? 121.785 133.719 144.838 1.00 62.98  ? 352 GLY A CA  1 
ATOM   1898 C C   . GLY A 1 352 ? 120.683 132.775 144.414 1.00 62.98  ? 352 GLY A C   1 
ATOM   1899 O O   . GLY A 1 352 ? 119.603 133.239 144.034 1.00 62.98  ? 352 GLY A O   1 
ATOM   1900 N N   . TYR A 1 353 ? 120.922 131.468 144.468 1.00 64.85  ? 353 TYR A N   1 
ATOM   1901 C CA  . TYR A 1 353 ? 119.935 130.479 144.059 1.00 64.85  ? 353 TYR A CA  1 
ATOM   1902 C C   . TYR A 1 353 ? 119.105 129.946 145.220 1.00 64.85  ? 353 TYR A C   1 
ATOM   1903 O O   . TYR A 1 353 ? 118.279 129.052 145.011 1.00 64.85  ? 353 TYR A O   1 
ATOM   1904 C CB  . TYR A 1 353 ? 120.624 129.313 143.344 1.00 64.85  ? 353 TYR A CB  1 
ATOM   1905 N N   . ILE A 1 354 ? 119.299 130.465 146.428 1.00 64.37  ? 354 ILE A N   1 
ATOM   1906 C CA  . ILE A 1 354 ? 118.579 129.988 147.604 1.00 64.37  ? 354 ILE A CA  1 
ATOM   1907 C C   . ILE A 1 354 ? 117.338 130.848 147.797 1.00 64.37  ? 354 ILE A C   1 
ATOM   1908 O O   . ILE A 1 354 ? 117.433 132.072 147.933 1.00 64.37  ? 354 ILE A O   1 
ATOM   1909 C CB  . ILE A 1 354 ? 119.471 130.019 148.854 1.00 64.37  ? 354 ILE A CB  1 
ATOM   1910 N N   . LYS A 1 355 ? 116.169 130.205 147.813 1.00 68.52  ? 355 LYS A N   1 
ATOM   1911 C CA  . LYS A 1 355 ? 114.896 130.904 147.984 1.00 68.52  ? 355 LYS A CA  1 
ATOM   1912 C C   . LYS A 1 355 ? 114.636 131.123 149.476 1.00 68.52  ? 355 LYS A C   1 
ATOM   1913 O O   . LYS A 1 355 ? 113.804 130.471 150.110 1.00 68.52  ? 355 LYS A O   1 
ATOM   1914 C CB  . LYS A 1 355 ? 113.767 130.124 147.325 1.00 68.52  ? 355 LYS A CB  1 
ATOM   1915 N N   . ILE A 1 356 ? 115.381 132.071 150.038 1.00 69.43  ? 356 ILE A N   1 
ATOM   1916 C CA  . ILE A 1 356 ? 115.265 132.436 151.443 1.00 69.43  ? 356 ILE A CA  1 
ATOM   1917 C C   . ILE A 1 356 ? 115.163 133.949 151.546 1.00 69.43  ? 356 ILE A C   1 
ATOM   1918 O O   . ILE A 1 356 ? 115.912 134.678 150.887 1.00 69.43  ? 356 ILE A O   1 
ATOM   1919 C CB  . ILE A 1 356 ? 116.459 131.915 152.270 1.00 69.43  ? 356 ILE A CB  1 
ATOM   1920 N N   . SER A 1 357 ? 114.235 134.419 152.372 1.00 72.63  ? 357 SER A N   1 
ATOM   1921 C CA  . SER A 1 357 ? 114.055 135.840 152.621 1.00 72.63  ? 357 SER A CA  1 
ATOM   1922 C C   . SER A 1 357 ? 114.947 136.281 153.773 1.00 72.63  ? 357 SER A C   1 
ATOM   1923 O O   . SER A 1 357 ? 115.274 135.494 154.666 1.00 72.63  ? 357 SER A O   1 
ATOM   1924 C CB  . SER A 1 357 ? 112.592 136.160 152.938 1.00 72.63  ? 357 SER A CB  1 
ATOM   1925 N N   . TRP A 1 358 ? 115.350 137.553 153.738 1.00 71.73  ? 358 TRP A N   1 
ATOM   1926 C CA  . TRP A 1 358 ? 116.249 138.075 154.764 1.00 71.73  ? 358 TRP A CA  1 
ATOM   1927 C C   . TRP A 1 358 ? 115.570 138.114 156.128 1.00 71.73  ? 358 TRP A C   1 
ATOM   1928 O O   . TRP A 1 358 ? 116.106 137.596 157.116 1.00 71.73  ? 358 TRP A O   1 
ATOM   1929 C CB  . TRP A 1 358 ? 116.738 139.467 154.367 1.00 71.73  ? 358 TRP A CB  1 
ATOM   1930 N N   . SER A 1 359 ? 114.370 138.697 156.191 1.00 74.37  ? 359 SER A N   1 
ATOM   1931 C CA  . SER A 1 359 ? 113.699 138.929 157.465 1.00 74.37  ? 359 SER A CA  1 
ATOM   1932 C C   . SER A 1 359 ? 113.322 137.640 158.181 1.00 74.37  ? 359 SER A C   1 
ATOM   1933 O O   . SER A 1 359 ? 113.066 137.674 159.389 1.00 74.37  ? 359 SER A O   1 
ATOM   1934 C CB  . SER A 1 359 ? 112.448 139.781 157.248 1.00 74.37  ? 359 SER A CB  1 
ATOM   1935 N N   . THR A 1 360 ? 113.278 136.509 157.476 1.00 73.05  ? 360 THR A N   1 
ATOM   1936 C CA  . THR A 1 360 ? 112.875 135.262 158.117 1.00 73.05  ? 360 THR A CA  1 
ATOM   1937 C C   . THR A 1 360 ? 113.973 134.733 159.032 1.00 73.05  ? 360 THR A C   1 
ATOM   1938 O O   . THR A 1 360 ? 113.797 134.654 160.254 1.00 73.05  ? 360 THR A O   1 
ATOM   1939 C CB  . THR A 1 360 ? 112.510 134.221 157.058 1.00 73.05  ? 360 THR A CB  1 
ATOM   1940 N N   . TRP A 1 361 ? 115.118 134.353 158.458 1.00 68.46  ? 361 TRP A N   1 
ATOM   1941 C CA  . TRP A 1 361 ? 116.202 133.807 159.265 1.00 68.46  ? 361 TRP A CA  1 
ATOM   1942 C C   . TRP A 1 361 ? 117.580 134.208 158.747 1.00 68.46  ? 361 TRP A C   1 
ATOM   1943 O O   . TRP A 1 361 ? 118.532 133.431 158.872 1.00 68.46  ? 361 TRP A O   1 
ATOM   1944 C CB  . TRP A 1 361 ? 116.107 132.281 159.344 1.00 68.46  ? 361 TRP A CB  1 
ATOM   1945 N N   . GLY A 1 362 ? 117.715 135.394 158.146 1.00 65.34  ? 362 GLY A N   1 
ATOM   1946 C CA  . GLY A 1 362 ? 119.005 135.770 157.584 1.00 65.34  ? 362 GLY A CA  1 
ATOM   1947 C C   . GLY A 1 362 ? 120.100 135.854 158.631 1.00 65.34  ? 362 GLY A C   1 
ATOM   1948 O O   . GLY A 1 362 ? 121.178 135.271 158.474 1.00 65.34  ? 362 GLY A O   1 
ATOM   1949 N N   . GLU A 1 363 ? 119.825 136.559 159.730 1.00 62.00  ? 363 GLU A N   1 
ATOM   1950 C CA  . GLU A 1 363 ? 120.811 136.683 160.797 1.00 62.00  ? 363 GLU A CA  1 
ATOM   1951 C C   . GLU A 1 363 ? 121.057 135.350 161.489 1.00 62.00  ? 363 GLU A C   1 
ATOM   1952 O O   . GLU A 1 363 ? 122.183 135.076 161.911 1.00 62.00  ? 363 GLU A O   1 
ATOM   1953 C CB  . GLU A 1 363 ? 120.363 137.735 161.809 1.00 62.00  ? 363 GLU A CB  1 
ATOM   1954 N N   . MET A 1 364 ? 120.023 134.515 161.615 1.00 63.87  ? 364 MET A N   1 
ATOM   1955 C CA  . MET A 1 364 ? 120.206 133.192 162.204 1.00 63.87  ? 364 MET A CA  1 
ATOM   1956 C C   . MET A 1 364 ? 121.146 132.335 161.362 1.00 63.87  ? 364 MET A C   1 
ATOM   1957 O O   . MET A 1 364 ? 122.052 131.680 161.897 1.00 63.87  ? 364 MET A O   1 
ATOM   1958 C CB  . MET A 1 364 ? 118.850 132.506 162.365 1.00 63.87  ? 364 MET A CB  1 
ATOM   1959 C CG  . MET A 1 364 ? 118.879 131.243 163.207 1.00 63.87  ? 364 MET A CG  1 
ATOM   1960 S SD  . MET A 1 364 ? 119.827 131.425 164.726 1.00 63.87  ? 364 MET A SD  1 
ATOM   1961 C CE  . MET A 1 364 ? 118.920 130.331 165.816 1.00 63.87  ? 364 MET A CE  1 
ATOM   1962 N N   . THR A 1 365 ? 120.951 132.332 160.041 1.00 63.67  ? 365 THR A N   1 
ATOM   1963 C CA  . THR A 1 365 ? 121.841 131.579 159.163 1.00 63.67  ? 365 THR A CA  1 
ATOM   1964 C C   . THR A 1 365 ? 123.252 132.148 159.182 1.00 63.67  ? 365 THR A C   1 
ATOM   1965 O O   . THR A 1 365 ? 124.230 131.391 159.152 1.00 63.67  ? 365 THR A O   1 
ATOM   1966 C CB  . THR A 1 365 ? 121.293 131.559 157.737 1.00 63.67  ? 365 THR A CB  1 
ATOM   1967 O OG1 . THR A 1 365 ? 121.207 132.899 157.235 1.00 63.67  ? 365 THR A OG1 1 
ATOM   1968 C CG2 . THR A 1 365 ? 119.927 130.892 157.694 1.00 63.67  ? 365 THR A CG2 1 
ATOM   1969 N N   . LEU A 1 366 ? 123.383 133.477 159.225 1.00 59.21  ? 366 LEU A N   1 
ATOM   1970 C CA  . LEU A 1 366 ? 124.713 134.073 159.310 1.00 59.21  ? 366 LEU A CA  1 
ATOM   1971 C C   . LEU A 1 366 ? 125.404 133.681 160.611 1.00 59.21  ? 366 LEU A C   1 
ATOM   1972 O O   . LEU A 1 366 ? 126.609 133.413 160.625 1.00 59.21  ? 366 LEU A O   1 
ATOM   1973 C CB  . LEU A 1 366 ? 124.616 135.594 159.174 1.00 59.21  ? 366 LEU A CB  1 
ATOM   1974 C CG  . LEU A 1 366 ? 125.897 136.415 158.978 1.00 59.21  ? 366 LEU A CG  1 
ATOM   1975 C CD1 . LEU A 1 366 ? 125.591 137.660 158.164 1.00 59.21  ? 366 LEU A CD1 1 
ATOM   1976 C CD2 . LEU A 1 366 ? 126.537 136.810 160.302 1.00 59.21  ? 366 LEU A CD2 1 
ATOM   1977 N N   . SER A 1 367 ? 124.655 133.643 161.716 1.00 57.57  ? 367 SER A N   1 
ATOM   1978 C CA  . SER A 1 367 ? 125.225 133.231 162.994 1.00 57.57  ? 367 SER A CA  1 
ATOM   1979 C C   . SER A 1 367 ? 125.653 131.771 162.966 1.00 57.57  ? 367 SER A C   1 
ATOM   1980 O O   . SER A 1 367 ? 126.700 131.411 163.517 1.00 57.57  ? 367 SER A O   1 
ATOM   1981 C CB  . SER A 1 367 ? 124.216 133.467 164.116 1.00 57.57  ? 367 SER A CB  1 
ATOM   1982 O OG  . SER A 1 367 ? 123.224 132.457 164.117 1.00 57.57  ? 367 SER A OG  1 
ATOM   1983 N N   . LEU A 1 368 ? 124.844 130.910 162.343 1.00 58.33  ? 368 LEU A N   1 
ATOM   1984 C CA  . LEU A 1 368 ? 125.226 129.507 162.209 1.00 58.33  ? 368 LEU A CA  1 
ATOM   1985 C C   . LEU A 1 368 ? 126.489 129.360 161.368 1.00 58.33  ? 368 LEU A C   1 
ATOM   1986 O O   . LEU A 1 368 ? 127.387 128.578 161.706 1.00 58.33  ? 368 LEU A O   1 
ATOM   1987 C CB  . LEU A 1 368 ? 124.075 128.708 161.599 1.00 58.33  ? 368 LEU A CB  1 
ATOM   1988 C CG  . LEU A 1 368 ? 124.291 127.202 161.449 1.00 58.33  ? 368 LEU A CG  1 
ATOM   1989 C CD1 . LEU A 1 368 ? 124.512 126.551 162.807 1.00 58.33  ? 368 LEU A CD1 1 
ATOM   1990 C CD2 . LEU A 1 368 ? 123.111 126.565 160.729 1.00 58.33  ? 368 LEU A CD2 1 
ATOM   1991 N N   . PHE A 1 369 ? 126.580 130.121 160.277 1.00 55.03  ? 369 PHE A N   1 
ATOM   1992 C CA  . PHE A 1 369 ? 127.779 130.099 159.446 1.00 55.03  ? 369 PHE A CA  1 
ATOM   1993 C C   . PHE A 1 369 ? 128.995 130.589 160.222 1.00 55.03  ? 369 PHE A C   1 
ATOM   1994 O O   . PHE A 1 369 ? 130.091 130.035 160.088 1.00 55.03  ? 369 PHE A O   1 
ATOM   1995 C CB  . PHE A 1 369 ? 127.557 130.950 158.196 1.00 55.03  ? 369 PHE A CB  1 
ATOM   1996 N N   . SER A 1 370 ? 128.820 131.629 161.037 1.00 52.25  ? 370 SER A N   1 
ATOM   1997 C CA  . SER A 1 370 ? 129.921 132.141 161.846 1.00 52.25  ? 370 SER A CA  1 
ATOM   1998 C C   . SER A 1 370 ? 130.370 131.128 162.893 1.00 52.25  ? 370 SER A C   1 
ATOM   1999 O O   . SER A 1 370 ? 131.570 130.992 163.158 1.00 52.25  ? 370 SER A O   1 
ATOM   2000 C CB  . SER A 1 370 ? 129.511 133.447 162.514 1.00 52.25  ? 370 SER A CB  1 
ATOM   2001 O OG  . SER A 1 370 ? 130.491 133.841 163.448 1.00 52.25  ? 370 SER A OG  1 
ATOM   2002 N N   . LEU A 1 371 ? 129.422 130.423 163.513 1.00 53.71  ? 371 LEU A N   1 
ATOM   2003 C CA  . LEU A 1 371 ? 129.790 129.379 164.464 1.00 53.71  ? 371 LEU A CA  1 
ATOM   2004 C C   . LEU A 1 371 ? 130.536 128.246 163.772 1.00 53.71  ? 371 LEU A C   1 
ATOM   2005 O O   . LEU A 1 371 ? 131.490 127.689 164.327 1.00 53.71  ? 371 LEU A O   1 
ATOM   2006 C CB  . LEU A 1 371 ? 128.551 128.849 165.182 1.00 53.71  ? 371 LEU A CB  1 
ATOM   2007 C CG  . LEU A 1 371 ? 128.840 127.790 166.251 1.00 53.71  ? 371 LEU A CG  1 
ATOM   2008 C CD1 . LEU A 1 371 ? 129.696 128.368 167.367 1.00 53.71  ? 371 LEU A CD1 1 
ATOM   2009 C CD2 . LEU A 1 371 ? 127.550 127.207 166.809 1.00 53.71  ? 371 LEU A CD2 1 
ATOM   2010 N N   . LEU A 1 372 ? 130.115 127.890 162.556 1.00 51.92  ? 372 LEU A N   1 
ATOM   2011 C CA  . LEU A 1 372 ? 130.860 126.897 161.785 1.00 51.92  ? 372 LEU A CA  1 
ATOM   2012 C C   . LEU A 1 372 ? 132.265 127.390 161.452 1.00 51.92  ? 372 LEU A C   1 
ATOM   2013 O O   . LEU A 1 372 ? 133.224 126.611 161.480 1.00 51.92  ? 372 LEU A O   1 
ATOM   2014 C CB  . LEU A 1 372 ? 130.096 126.532 160.513 1.00 51.92  ? 372 LEU A CB  1 
ATOM   2015 C CG  . LEU A 1 372 ? 129.160 125.320 160.570 1.00 51.92  ? 372 LEU A CG  1 
ATOM   2016 C CD1 . LEU A 1 372 ? 129.971 124.053 160.773 1.00 51.92  ? 372 LEU A CD1 1 
ATOM   2017 C CD2 . LEU A 1 372 ? 128.110 125.455 161.660 1.00 51.92  ? 372 LEU A CD2 1 
ATOM   2018 N N   . ILE A 1 373 ? 132.404 128.679 161.133 1.00 48.05  ? 373 ILE A N   1 
ATOM   2019 C CA  . ILE A 1 373 ? 133.727 129.252 160.884 1.00 48.05  ? 373 ILE A CA  1 
ATOM   2020 C C   . ILE A 1 373 ? 134.596 129.139 162.129 1.00 48.05  ? 373 ILE A C   1 
ATOM   2021 O O   . ILE A 1 373 ? 135.777 128.781 162.052 1.00 48.05  ? 373 ILE A O   1 
ATOM   2022 C CB  . ILE A 1 373 ? 133.600 130.716 160.421 1.00 48.05  ? 373 ILE A CB  1 
ATOM   2023 C CG1 . ILE A 1 373 ? 133.243 130.792 158.941 1.00 48.05  ? 373 ILE A CG1 1 
ATOM   2024 C CG2 . ILE A 1 373 ? 134.894 131.466 160.658 1.00 48.05  ? 373 ILE A CG2 1 
ATOM   2025 C CD1 . ILE A 1 373 ? 132.928 132.195 158.470 1.00 48.05  ? 373 ILE A CD1 1 
ATOM   2026 N N   . ALA A 1 374 ? 134.024 129.454 163.294 1.00 48.76  ? 374 ALA A N   1 
ATOM   2027 C CA  . ALA A 1 374 ? 134.767 129.350 164.546 1.00 48.76  ? 374 ALA A CA  1 
ATOM   2028 C C   . ALA A 1 374 ? 135.188 127.913 164.820 1.00 48.76  ? 374 ALA A C   1 
ATOM   2029 O O   . ALA A 1 374 ? 136.316 127.660 165.262 1.00 48.76  ? 374 ALA A O   1 
ATOM   2030 C CB  . ALA A 1 374 ? 133.923 129.884 165.703 1.00 48.76  ? 374 ALA A CB  1 
ATOM   2031 N N   . ALA A 1 375 ? 134.287 126.961 164.571 1.00 48.41  ? 375 ALA A N   1 
ATOM   2032 C CA  . ALA A 1 375 ? 134.623 125.554 164.755 1.00 48.41  ? 375 ALA A CA  1 
ATOM   2033 C C   . ALA A 1 375 ? 135.745 125.132 163.817 1.00 48.41  ? 375 ALA A C   1 
ATOM   2034 O O   . ALA A 1 375 ? 136.653 124.394 164.215 1.00 48.41  ? 375 ALA A O   1 
ATOM   2035 C CB  . ALA A 1 375 ? 133.384 124.688 164.540 1.00 48.41  ? 375 ALA A CB  1 
ATOM   2036 N N   . ALA A 1 376 ? 135.703 125.600 162.568 1.00 46.50  ? 376 ALA A N   1 
ATOM   2037 C CA  . ALA A 1 376 ? 136.764 125.285 161.618 1.00 46.50  ? 376 ALA A CA  1 
ATOM   2038 C C   . ALA A 1 376 ? 138.098 125.874 162.059 1.00 46.50  ? 376 ALA A C   1 
ATOM   2039 O O   . ALA A 1 376 ? 139.138 125.220 161.941 1.00 46.50  ? 376 ALA A O   1 
ATOM   2040 C CB  . ALA A 1 376 ? 136.390 125.792 160.226 1.00 46.50  ? 376 ALA A CB  1 
ATOM   2041 N N   . VAL A 1 377 ? 138.088 127.110 162.564 1.00 47.92  ? 377 VAL A N   1 
ATOM   2042 C CA  . VAL A 1 377 ? 139.326 127.745 163.014 1.00 47.92  ? 377 VAL A CA  1 
ATOM   2043 C C   . VAL A 1 377 ? 139.906 127.000 164.211 1.00 47.92  ? 377 VAL A C   1 
ATOM   2044 O O   . VAL A 1 377 ? 141.113 126.728 164.267 1.00 47.92  ? 377 VAL A O   1 
ATOM   2045 C CB  . VAL A 1 377 ? 139.081 129.232 163.336 1.00 47.92  ? 377 VAL A CB  1 
ATOM   2046 C CG1 . VAL A 1 377 ? 140.280 129.828 164.048 1.00 47.92  ? 377 VAL A CG1 1 
ATOM   2047 C CG2 . VAL A 1 377 ? 138.789 130.008 162.067 1.00 47.92  ? 377 VAL A CG2 1 
ATOM   2048 N N   . TYR A 1 378 ? 139.055 126.649 165.180 1.00 49.36  ? 378 TYR A N   1 
ATOM   2049 C CA  . TYR A 1 378 ? 139.523 125.899 166.342 1.00 49.36  ? 378 TYR A CA  1 
ATOM   2050 C C   . TYR A 1 378 ? 140.067 124.535 165.938 1.00 49.36  ? 378 TYR A C   1 
ATOM   2051 O O   . TYR A 1 378 ? 141.104 124.092 166.450 1.00 49.36  ? 378 TYR A O   1 
ATOM   2052 C CB  . TYR A 1 378 ? 138.388 125.747 167.352 1.00 49.36  ? 378 TYR A CB  1 
ATOM   2053 C CG  . TYR A 1 378 ? 138.736 124.899 168.551 1.00 49.36  ? 378 TYR A CG  1 
ATOM   2054 C CD1 . TYR A 1 378 ? 139.595 125.370 169.533 1.00 49.36  ? 378 TYR A CD1 1 
ATOM   2055 C CD2 . TYR A 1 378 ? 138.193 123.632 168.710 1.00 49.36  ? 378 TYR A CD2 1 
ATOM   2056 C CE1 . TYR A 1 378 ? 139.911 124.600 170.633 1.00 49.36  ? 378 TYR A CE1 1 
ATOM   2057 C CE2 . TYR A 1 378 ? 138.504 122.856 169.806 1.00 49.36  ? 378 TYR A CE2 1 
ATOM   2058 C CZ  . TYR A 1 378 ? 139.363 123.344 170.764 1.00 49.36  ? 378 TYR A CZ  1 
ATOM   2059 O OH  . TYR A 1 378 ? 139.676 122.572 171.859 1.00 49.36  ? 378 TYR A OH  1 
ATOM   2060 N N   . ILE A 1 379 ? 139.382 123.859 165.013 1.00 48.12  ? 379 ILE A N   1 
ATOM   2061 C CA  . ILE A 1 379 ? 139.844 122.564 164.525 1.00 48.12  ? 379 ILE A CA  1 
ATOM   2062 C C   . ILE A 1 379 ? 141.202 122.707 163.851 1.00 48.12  ? 379 ILE A C   1 
ATOM   2063 O O   . ILE A 1 379 ? 142.145 121.971 164.156 1.00 48.12  ? 379 ILE A O   1 
ATOM   2064 C CB  . ILE A 1 379 ? 138.795 121.954 163.579 1.00 48.12  ? 379 ILE A CB  1 
ATOM   2065 C CG1 . ILE A 1 379 ? 137.683 121.283 164.388 1.00 48.12  ? 379 ILE A CG1 1 
ATOM   2066 C CG2 . ILE A 1 379 ? 139.431 120.972 162.614 1.00 48.12  ? 379 ILE A CG2 1 
ATOM   2067 C CD1 . ILE A 1 379 ? 136.444 120.969 163.583 1.00 48.12  ? 379 ILE A CD1 1 
ATOM   2068 N N   . MET A 1 380 ? 141.331 123.687 162.952 1.00 47.57  ? 380 MET A N   1 
ATOM   2069 C CA  . MET A 1 380 ? 142.596 123.923 162.267 1.00 47.57  ? 380 MET A CA  1 
ATOM   2070 C C   . MET A 1 380 ? 143.716 124.231 163.248 1.00 47.57  ? 380 MET A C   1 
ATOM   2071 O O   . MET A 1 380 ? 144.870 123.855 163.014 1.00 47.57  ? 380 MET A O   1 
ATOM   2072 C CB  . MET A 1 380 ? 142.434 125.068 161.266 1.00 47.57  ? 380 MET A CB  1 
ATOM   2073 C CG  . MET A 1 380 ? 143.673 125.380 160.446 1.00 47.57  ? 380 MET A CG  1 
ATOM   2074 S SD  . MET A 1 380 ? 143.398 126.716 159.269 1.00 47.57  ? 380 MET A SD  1 
ATOM   2075 C CE  . MET A 1 380 ? 143.306 128.122 160.369 1.00 47.57  ? 380 MET A CE  1 
ATOM   2076 N N   . ASP A 1 381 ? 143.396 124.903 164.353 1.00 47.90  ? 381 ASP A N   1 
ATOM   2077 C CA  . ASP A 1 381 ? 144.423 125.224 165.335 1.00 47.90  ? 381 ASP A CA  1 
ATOM   2078 C C   . ASP A 1 381 ? 144.806 124.015 166.187 1.00 47.90  ? 381 ASP A C   1 
ATOM   2079 O O   . ASP A 1 381 ? 145.960 123.901 166.613 1.00 47.90  ? 381 ASP A O   1 
ATOM   2080 C CB  . ASP A 1 381 ? 143.951 126.375 166.222 1.00 47.90  ? 381 ASP A CB  1 
ATOM   2081 C CG  . ASP A 1 381 ? 145.055 126.922 167.104 1.00 47.90  ? 381 ASP A CG  1 
ATOM   2082 O OD1 . ASP A 1 381 ? 146.241 126.651 166.826 1.00 47.90  ? 381 ASP A OD1 1 
ATOM   2083 O OD2 . ASP A 1 381 ? 144.736 127.641 168.071 1.00 47.90  ? 381 ASP A OD2 1 
ATOM   2084 N N   . THR A 1 382 ? 143.869 123.098 166.443 1.00 50.01  ? 382 THR A N   1 
ATOM   2085 C CA  . THR A 1 382 ? 144.079 122.097 167.483 1.00 50.01  ? 382 THR A CA  1 
ATOM   2086 C C   . THR A 1 382 ? 144.230 120.655 167.005 1.00 50.01  ? 382 THR A C   1 
ATOM   2087 O O   . THR A 1 382 ? 144.570 119.796 167.826 1.00 50.01  ? 382 THR A O   1 
ATOM   2088 C CB  . THR A 1 382 ? 142.935 122.160 168.503 1.00 50.01  ? 382 THR A CB  1 
ATOM   2089 O OG1 . THR A 1 382 ? 141.679 122.114 167.817 1.00 50.01  ? 382 THR A OG1 1 
ATOM   2090 C CG2 . THR A 1 382 ? 143.022 123.441 169.312 1.00 50.01  ? 382 THR A CG2 1 
ATOM   2091 N N   . VAL A 1 383 ? 143.990 120.349 165.728 1.00 51.42  ? 383 VAL A N   1 
ATOM   2092 C CA  . VAL A 1 383 ? 144.066 118.952 165.298 1.00 51.42  ? 383 VAL A CA  1 
ATOM   2093 C C   . VAL A 1 383 ? 145.507 118.453 165.296 1.00 51.42  ? 383 VAL A C   1 
ATOM   2094 O O   . VAL A 1 383 ? 145.781 117.315 165.695 1.00 51.42  ? 383 VAL A O   1 
ATOM   2095 C CB  . VAL A 1 383 ? 143.405 118.756 163.922 1.00 51.42  ? 383 VAL A CB  1 
ATOM   2096 C CG1 . VAL A 1 383 ? 141.898 118.828 164.047 1.00 51.42  ? 383 VAL A CG1 1 
ATOM   2097 C CG2 . VAL A 1 383 ? 143.926 119.779 162.922 1.00 51.42  ? 383 VAL A CG2 1 
ATOM   2098 N N   . GLY A 1 384 ? 146.446 119.279 164.844 1.00 51.15  ? 384 GLY A N   1 
ATOM   2099 C CA  . GLY A 1 384 ? 147.816 118.831 164.708 1.00 51.15  ? 384 GLY A CA  1 
ATOM   2100 C C   . GLY A 1 384 ? 148.088 117.988 163.485 1.00 51.15  ? 384 GLY A C   1 
ATOM   2101 O O   . GLY A 1 384 ? 149.156 117.375 163.395 1.00 51.15  ? 384 GLY A O   1 
ATOM   2102 N N   . ASN A 1 385 ? 147.154 117.934 162.539 1.00 52.86  ? 385 ASN A N   1 
ATOM   2103 C CA  . ASN A 1 385 ? 147.335 117.228 161.277 1.00 52.86  ? 385 ASN A CA  1 
ATOM   2104 C C   . ASN A 1 385 ? 147.190 118.230 160.142 1.00 52.86  ? 385 ASN A C   1 
ATOM   2105 O O   . ASN A 1 385 ? 146.352 119.135 160.210 1.00 52.86  ? 385 ASN A O   1 
ATOM   2106 C CB  . ASN A 1 385 ? 146.329 116.084 161.124 1.00 52.86  ? 385 ASN A CB  1 
ATOM   2107 C CG  . ASN A 1 385 ? 146.777 115.044 160.116 1.00 52.86  ? 385 ASN A CG  1 
ATOM   2108 O OD1 . ASN A 1 385 ? 147.511 115.347 159.176 1.00 52.86  ? 385 ASN A OD1 1 
ATOM   2109 N ND2 . ASN A 1 385 ? 146.334 113.808 160.308 1.00 52.86  ? 385 ASN A ND2 1 
ATOM   2110 N N   . ILE A 1 386 ? 148.005 118.063 159.101 1.00 49.74  ? 386 ILE A N   1 
ATOM   2111 C CA  . ILE A 1 386 ? 148.167 119.129 158.118 1.00 49.74  ? 386 ILE A CA  1 
ATOM   2112 C C   . ILE A 1 386 ? 147.071 119.072 157.051 1.00 49.74  ? 386 ILE A C   1 
ATOM   2113 O O   . ILE A 1 386 ? 146.497 120.104 156.683 1.00 49.74  ? 386 ILE A O   1 
ATOM   2114 C CB  . ILE A 1 386 ? 149.594 119.079 157.529 1.00 49.74  ? 386 ILE A CB  1 
ATOM   2115 C CG1 . ILE A 1 386 ? 149.923 120.365 156.772 1.00 49.74  ? 386 ILE A CG1 1 
ATOM   2116 C CG2 . ILE A 1 386 ? 149.835 117.826 156.684 1.00 49.74  ? 386 ILE A CG2 1 
ATOM   2117 C CD1 . ILE A 1 386 ? 149.970 121.600 157.640 1.00 49.74  ? 386 ILE A CD1 1 
ATOM   2118 N N   . TRP A 1 387 ? 146.747 117.878 156.547 1.00 50.24  ? 387 TRP A N   1 
ATOM   2119 C CA  . TRP A 1 387 ? 145.744 117.780 155.489 1.00 50.24  ? 387 TRP A CA  1 
ATOM   2120 C C   . TRP A 1 387 ? 144.369 118.211 155.986 1.00 50.24  ? 387 TRP A C   1 
ATOM   2121 O O   . TRP A 1 387 ? 143.648 118.946 155.294 1.00 50.24  ? 387 TRP A O   1 
ATOM   2122 C CB  . TRP A 1 387 ? 145.701 116.353 154.946 1.00 50.24  ? 387 TRP A CB  1 
ATOM   2123 C CG  . TRP A 1 387 ? 147.059 115.750 154.745 1.00 50.24  ? 387 TRP A CG  1 
ATOM   2124 C CD1 . TRP A 1 387 ? 147.690 114.862 155.566 1.00 50.24  ? 387 TRP A CD1 1 
ATOM   2125 C CD2 . TRP A 1 387 ? 147.952 115.988 153.650 1.00 50.24  ? 387 TRP A CD2 1 
ATOM   2126 N NE1 . TRP A 1 387 ? 148.921 114.533 155.051 1.00 50.24  ? 387 TRP A NE1 1 
ATOM   2127 C CE2 . TRP A 1 387 ? 149.105 115.212 153.876 1.00 50.24  ? 387 TRP A CE2 1 
ATOM   2128 C CE3 . TRP A 1 387 ? 147.888 116.783 152.502 1.00 50.24  ? 387 TRP A CE3 1 
ATOM   2129 C CZ2 . TRP A 1 387 ? 150.186 115.207 152.996 1.00 50.24  ? 387 TRP A CZ2 1 
ATOM   2130 C CZ3 . TRP A 1 387 ? 148.961 116.776 151.630 1.00 50.24  ? 387 TRP A CZ3 1 
ATOM   2131 C CH2 . TRP A 1 387 ? 150.094 115.993 151.882 1.00 50.24  ? 387 TRP A CH2 1 
ATOM   2132 N N   . VAL A 1 388 ? 143.996 117.783 157.193 1.00 49.82  ? 388 VAL A N   1 
ATOM   2133 C CA  . VAL A 1 388 ? 142.704 118.172 157.740 1.00 49.82  ? 388 VAL A CA  1 
ATOM   2134 C C   . VAL A 1 388 ? 142.673 119.665 158.048 1.00 49.82  ? 388 VAL A C   1 
ATOM   2135 O O   . VAL A 1 388 ? 141.611 120.294 157.972 1.00 49.82  ? 388 VAL A O   1 
ATOM   2136 C CB  . VAL A 1 388 ? 142.360 117.313 158.973 1.00 49.82  ? 388 VAL A CB  1 
ATOM   2137 C CG1 . VAL A 1 388 ? 143.269 117.642 160.133 1.00 49.82  ? 388 VAL A CG1 1 
ATOM   2138 C CG2 . VAL A 1 388 ? 140.897 117.487 159.362 1.00 49.82  ? 388 VAL A CG2 1 
ATOM   2139 N N   . CYS A 1 389 ? 143.821 120.275 158.367 1.00 50.11  ? 389 CYS A N   1 
ATOM   2140 C CA  . CYS A 1 389 ? 143.784 121.713 158.607 1.00 50.11  ? 389 CYS A CA  1 
ATOM   2141 C C   . CYS A 1 389 ? 143.691 122.497 157.302 1.00 50.11  ? 389 CYS A C   1 
ATOM   2142 O O   . CYS A 1 389 ? 143.037 123.546 157.272 1.00 50.11  ? 389 CYS A O   1 
ATOM   2143 C CB  . CYS A 1 389 ? 144.986 122.179 159.437 1.00 50.11  ? 389 CYS A CB  1 
ATOM   2144 S SG  . CYS A 1 389 ? 146.571 122.331 158.609 1.00 50.11  ? 389 CYS A SG  1 
ATOM   2145 N N   . TYR A 1 390 ? 144.288 122.002 156.207 1.00 47.46  ? 390 TYR A N   1 
ATOM   2146 C CA  . TYR A 1 390 ? 143.982 122.607 154.911 1.00 47.46  ? 390 TYR A CA  1 
ATOM   2147 C C   . TYR A 1 390 ? 142.500 122.477 154.589 1.00 47.46  ? 390 TYR A C   1 
ATOM   2148 O O   . TYR A 1 390 ? 141.885 123.415 154.066 1.00 47.46  ? 390 TYR A O   1 
ATOM   2149 C CB  . TYR A 1 390 ? 144.778 121.985 153.762 1.00 47.46  ? 390 TYR A CB  1 
ATOM   2150 C CG  . TYR A 1 390 ? 146.272 122.191 153.737 1.00 47.46  ? 390 TYR A CG  1 
ATOM   2151 C CD1 . TYR A 1 390 ? 146.820 123.379 153.276 1.00 47.46  ? 390 TYR A CD1 1 
ATOM   2152 C CD2 . TYR A 1 390 ? 147.132 121.143 154.003 1.00 47.46  ? 390 TYR A CD2 1 
ATOM   2153 C CE1 . TYR A 1 390 ? 148.184 123.552 153.201 1.00 47.46  ? 390 TYR A CE1 1 
ATOM   2154 C CE2 . TYR A 1 390 ? 148.492 121.302 153.922 1.00 47.46  ? 390 TYR A CE2 1 
ATOM   2155 C CZ  . TYR A 1 390 ? 149.015 122.506 153.525 1.00 47.46  ? 390 TYR A CZ  1 
ATOM   2156 O OH  . TYR A 1 390 ? 150.377 122.657 153.449 1.00 47.46  ? 390 TYR A OH  1 
ATOM   2157 N N   . ALA A 1 391 ? 141.916 121.307 154.866 1.00 46.65  ? 391 ALA A N   1 
ATOM   2158 C CA  . ALA A 1 391 ? 140.496 121.105 154.585 1.00 46.65  ? 391 ALA A CA  1 
ATOM   2159 C C   . ALA A 1 391 ? 139.628 122.065 155.391 1.00 46.65  ? 391 ALA A C   1 
ATOM   2160 O O   . ALA A 1 391 ? 138.659 122.632 154.870 1.00 46.65  ? 391 ALA A O   1 
ATOM   2161 C CB  . ALA A 1 391 ? 140.108 119.657 154.876 1.00 46.65  ? 391 ALA A CB  1 
ATOM   2162 N N   . SER A 1 392 ? 139.963 122.258 156.667 1.00 45.62  ? 392 SER A N   1 
ATOM   2163 C CA  . SER A 1 392 ? 139.228 123.205 157.497 1.00 45.62  ? 392 SER A CA  1 
ATOM   2164 C C   . SER A 1 392 ? 139.424 124.634 157.008 1.00 45.62  ? 392 SER A C   1 
ATOM   2165 O O   . SER A 1 392 ? 138.506 125.456 157.095 1.00 45.62  ? 392 SER A O   1 
ATOM   2166 C CB  . SER A 1 392 ? 139.665 123.065 158.951 1.00 45.62  ? 392 SER A CB  1 
ATOM   2167 O OG  . SER A 1 392 ? 141.051 123.306 159.068 1.00 45.62  ? 392 SER A OG  1 
ATOM   2168 N N   . TYR A 1 393 ? 140.612 124.950 156.488 1.00 44.99  ? 393 TYR A N   1 
ATOM   2169 C CA  . TYR A 1 393 ? 140.814 126.256 155.870 1.00 44.99  ? 393 TYR A CA  1 
ATOM   2170 C C   . TYR A 1 393 ? 139.906 126.430 154.658 1.00 44.99  ? 393 TYR A C   1 
ATOM   2171 O O   . TYR A 1 393 ? 139.337 127.507 154.449 1.00 44.99  ? 393 TYR A O   1 
ATOM   2172 C CB  . TYR A 1 393 ? 142.285 126.432 155.485 1.00 44.99  ? 393 TYR A CB  1 
ATOM   2173 C CG  . TYR A 1 393 ? 142.580 127.654 154.638 1.00 44.99  ? 393 TYR A CG  1 
ATOM   2174 C CD1 . TYR A 1 393 ? 142.577 127.586 153.252 1.00 44.99  ? 393 TYR A CD1 1 
ATOM   2175 C CD2 . TYR A 1 393 ? 142.852 128.880 155.229 1.00 44.99  ? 393 TYR A CD2 1 
ATOM   2176 C CE1 . TYR A 1 393 ? 142.844 128.699 152.482 1.00 44.99  ? 393 TYR A CE1 1 
ATOM   2177 C CE2 . TYR A 1 393 ? 143.120 129.998 154.466 1.00 44.99  ? 393 TYR A CE2 1 
ATOM   2178 C CZ  . TYR A 1 393 ? 143.114 129.901 153.093 1.00 44.99  ? 393 TYR A CZ  1 
ATOM   2179 O OH  . TYR A 1 393 ? 143.377 131.012 152.327 1.00 44.99  ? 393 TYR A OH  1 
ATOM   2180 N N   . VAL A 1 394 ? 139.756 125.378 153.852 1.00 46.53  ? 394 VAL A N   1 
ATOM   2181 C CA  . VAL A 1 394 ? 138.872 125.442 152.687 1.00 46.53  ? 394 VAL A CA  1 
ATOM   2182 C C   . VAL A 1 394 ? 137.425 125.647 153.127 1.00 46.53  ? 394 VAL A C   1 
ATOM   2183 O O   . VAL A 1 394 ? 136.668 126.407 152.509 1.00 46.53  ? 394 VAL A O   1 
ATOM   2184 C CB  . VAL A 1 394 ? 139.028 124.178 151.823 1.00 46.53  ? 394 VAL A CB  1 
ATOM   2185 C CG1 . VAL A 1 394 ? 138.035 124.193 150.671 1.00 46.53  ? 394 VAL A CG1 1 
ATOM   2186 C CG2 . VAL A 1 394 ? 140.446 124.067 151.297 1.00 46.53  ? 394 VAL A CG2 1 
ATOM   2187 N N   . VAL A 1 395 ? 137.018 124.955 154.195 1.00 46.38  ? 395 VAL A N   1 
ATOM   2188 C CA  . VAL A 1 395 ? 135.672 125.140 154.739 1.00 46.38  ? 395 VAL A CA  1 
ATOM   2189 C C   . VAL A 1 395 ? 135.479 126.575 155.210 1.00 46.38  ? 395 VAL A C   1 
ATOM   2190 O O   . VAL A 1 395 ? 134.425 127.185 154.984 1.00 46.38  ? 395 VAL A O   1 
ATOM   2191 C CB  . VAL A 1 395 ? 135.406 124.134 155.875 1.00 46.38  ? 395 VAL A CB  1 
ATOM   2192 C CG1 . VAL A 1 395 ? 134.033 124.369 156.477 1.00 46.38  ? 395 VAL A CG1 1 
ATOM   2193 C CG2 . VAL A 1 395 ? 135.514 122.714 155.356 1.00 46.38  ? 395 VAL A CG2 1 
ATOM   2194 N N   . PHE A 1 396 ? 136.489 127.127 155.889 1.00 43.91  ? 396 PHE A N   1 
ATOM   2195 C CA  . PHE A 1 396 ? 136.471 128.539 156.255 1.00 43.91  ? 396 PHE A CA  1 
ATOM   2196 C C   . PHE A 1 396 ? 136.253 129.421 155.035 1.00 43.91  ? 396 PHE A C   1 
ATOM   2197 O O   . PHE A 1 396 ? 135.430 130.341 155.061 1.00 43.91  ? 396 PHE A O   1 
ATOM   2198 C CB  . PHE A 1 396 ? 137.781 128.929 156.937 1.00 43.91  ? 396 PHE A CB  1 
ATOM   2199 C CG  . PHE A 1 396 ? 137.925 130.409 157.146 1.00 43.91  ? 396 PHE A CG  1 
ATOM   2200 C CD1 . PHE A 1 396 ? 136.880 131.164 157.655 1.00 43.91  ? 396 PHE A CD1 1 
ATOM   2201 C CD2 . PHE A 1 396 ? 139.074 131.059 156.744 1.00 43.91  ? 396 PHE A CD2 1 
ATOM   2202 C CE1 . PHE A 1 396 ? 137.006 132.528 157.815 1.00 43.91  ? 396 PHE A CE1 1 
ATOM   2203 C CE2 . PHE A 1 396 ? 139.198 132.417 156.890 1.00 43.91  ? 396 PHE A CE2 1 
ATOM   2204 C CZ  . PHE A 1 396 ? 138.165 133.154 157.432 1.00 43.91  ? 396 PHE A CZ  1 
ATOM   2205 N N   . ARG A 1 397 ? 137.009 129.170 153.966 1.00 45.57  ? 397 ARG A N   1 
ATOM   2206 C CA  . ARG A 1 397 ? 136.889 129.982 152.758 1.00 45.57  ? 397 ARG A CA  1 
ATOM   2207 C C   . ARG A 1 397 ? 135.475 129.922 152.196 1.00 45.57  ? 397 ARG A C   1 
ATOM   2208 O O   . ARG A 1 397 ? 134.880 130.956 151.870 1.00 45.57  ? 397 ARG A O   1 
ATOM   2209 C CB  . ARG A 1 397 ? 137.899 129.516 151.711 1.00 45.57  ? 397 ARG A CB  1 
ATOM   2210 C CG  . ARG A 1 397 ? 139.342 129.540 152.170 1.00 45.57  ? 397 ARG A CG  1 
ATOM   2211 C CD  . ARG A 1 397 ? 139.944 130.925 152.077 1.00 45.57  ? 397 ARG A CD  1 
ATOM   2212 N NE  . ARG A 1 397 ? 139.514 131.613 150.868 1.00 45.57  ? 397 ARG A NE  1 
ATOM   2213 C CZ  . ARG A 1 397 ? 140.162 132.629 150.318 1.00 45.57  ? 397 ARG A CZ  1 
ATOM   2214 N NH1 . ARG A 1 397 ? 141.288 133.091 150.836 1.00 45.57  ? 397 ARG A NH1 1 
ATOM   2215 N NH2 . ARG A 1 397 ? 139.669 133.197 149.221 1.00 45.57  ? 397 ARG A NH2 1 
ATOM   2216 N N   . ILE A 1 398 ? 134.914 128.715 152.102 1.00 47.99  ? 398 ILE A N   1 
ATOM   2217 C CA  . ILE A 1 398 ? 133.582 128.551 151.522 1.00 47.99  ? 398 ILE A CA  1 
ATOM   2218 C C   . ILE A 1 398 ? 132.538 129.279 152.362 1.00 47.99  ? 398 ILE A C   1 
ATOM   2219 O O   . ILE A 1 398 ? 131.704 130.034 151.840 1.00 47.99  ? 398 ILE A O   1 
ATOM   2220 C CB  . ILE A 1 398 ? 133.242 127.057 151.380 1.00 47.99  ? 398 ILE A CB  1 
ATOM   2221 C CG1 . ILE A 1 398 ? 134.211 126.376 150.416 1.00 47.99  ? 398 ILE A CG1 1 
ATOM   2222 C CG2 . ILE A 1 398 ? 131.813 126.880 150.899 1.00 47.99  ? 398 ILE A CG2 1 
ATOM   2223 C CD1 . ILE A 1 398 ? 134.107 124.868 150.424 1.00 47.99  ? 398 ILE A CD1 1 
ATOM   2224 N N   . ILE A 1 399 ? 132.575 129.069 153.679 1.00 47.87  ? 399 ILE A N   1 
ATOM   2225 C CA  . ILE A 1 399 ? 131.559 129.657 154.544 1.00 47.87  ? 399 ILE A CA  1 
ATOM   2226 C C   . ILE A 1 399 ? 131.708 131.172 154.594 1.00 47.87  ? 399 ILE A C   1 
ATOM   2227 O O   . ILE A 1 399 ? 130.712 131.907 154.623 1.00 47.87  ? 399 ILE A O   1 
ATOM   2228 C CB  . ILE A 1 399 ? 131.622 129.024 155.944 1.00 47.87  ? 399 ILE A CB  1 
ATOM   2229 C CG1 . ILE A 1 399 ? 131.405 127.516 155.844 1.00 47.87  ? 399 ILE A CG1 1 
ATOM   2230 C CG2 . ILE A 1 399 ? 130.563 129.616 156.839 1.00 47.87  ? 399 ILE A CG2 1 
ATOM   2231 C CD1 . ILE A 1 399 ? 131.362 126.820 157.175 1.00 47.87  ? 399 ILE A CD1 1 
ATOM   2232 N N   . TYR A 1 400 ? 132.948 131.668 154.588 1.00 46.48  ? 400 TYR A N   1 
ATOM   2233 C CA  . TYR A 1 400 ? 133.168 133.107 154.558 1.00 46.48  ? 400 TYR A CA  1 
ATOM   2234 C C   . TYR A 1 400 ? 132.651 133.720 153.268 1.00 46.48  ? 400 TYR A C   1 
ATOM   2235 O O   . TYR A 1 400 ? 132.070 134.808 153.286 1.00 46.48  ? 400 TYR A O   1 
ATOM   2236 C CB  . TYR A 1 400 ? 134.650 133.423 154.727 1.00 46.48  ? 400 TYR A CB  1 
ATOM   2237 C CG  . TYR A 1 400 ? 134.949 134.901 154.636 1.00 46.48  ? 400 TYR A CG  1 
ATOM   2238 C CD1 . TYR A 1 400 ? 134.593 135.770 155.655 1.00 46.48  ? 400 TYR A CD1 1 
ATOM   2239 C CD2 . TYR A 1 400 ? 135.560 135.430 153.509 1.00 46.48  ? 400 TYR A CD2 1 
ATOM   2240 C CE1 . TYR A 1 400 ? 134.859 137.120 155.563 1.00 46.48  ? 400 TYR A CE1 1 
ATOM   2241 C CE2 . TYR A 1 400 ? 135.827 136.775 153.407 1.00 46.48  ? 400 TYR A CE2 1 
ATOM   2242 C CZ  . TYR A 1 400 ? 135.481 137.615 154.435 1.00 46.48  ? 400 TYR A CZ  1 
ATOM   2243 O OH  . TYR A 1 400 ? 135.750 138.957 154.323 1.00 46.48  ? 400 TYR A OH  1 
ATOM   2244 N N   . MET A 1 401 ? 132.867 133.050 152.133 1.00 49.60  ? 401 MET A N   1 
ATOM   2245 C CA  . MET A 1 401 ? 132.344 133.573 150.875 1.00 49.60  ? 401 MET A CA  1 
ATOM   2246 C C   . MET A 1 401 ? 130.822 133.594 150.876 1.00 49.60  ? 401 MET A C   1 
ATOM   2247 O O   . MET A 1 401 ? 130.212 134.558 150.403 1.00 49.60  ? 401 MET A O   1 
ATOM   2248 C CB  . MET A 1 401 ? 132.879 132.769 149.693 1.00 49.60  ? 401 MET A CB  1 
ATOM   2249 C CG  . MET A 1 401 ? 134.378 132.906 149.497 1.00 49.60  ? 401 MET A CG  1 
ATOM   2250 S SD  . MET A 1 401 ? 134.875 134.607 149.170 1.00 49.60  ? 401 MET A SD  1 
ATOM   2251 C CE  . MET A 1 401 ? 134.184 134.851 147.536 1.00 49.60  ? 401 MET A CE  1 
ATOM   2252 N N   . LEU A 1 402 ? 130.190 132.548 151.414 1.00 53.16  ? 402 LEU A N   1 
ATOM   2253 C CA  . LEU A 1 402 ? 128.731 132.549 151.520 1.00 53.16  ? 402 LEU A CA  1 
ATOM   2254 C C   . LEU A 1 402 ? 128.243 133.710 152.385 1.00 53.16  ? 402 LEU A C   1 
ATOM   2255 O O   . LEU A 1 402 ? 127.311 134.441 152.010 1.00 53.16  ? 402 LEU A O   1 
ATOM   2256 C CB  . LEU A 1 402 ? 128.248 131.216 152.092 1.00 53.16  ? 402 LEU A CB  1 
ATOM   2257 C CG  . LEU A 1 402 ? 128.200 130.021 151.139 1.00 53.16  ? 402 LEU A CG  1 
ATOM   2258 C CD1 . LEU A 1 402 ? 128.070 128.717 151.914 1.00 53.16  ? 402 LEU A CD1 1 
ATOM   2259 C CD2 . LEU A 1 402 ? 127.058 130.173 150.148 1.00 53.16  ? 402 LEU A CD2 1 
ATOM   2260 N N   . LEU A 1 403 ? 128.880 133.901 153.543 1.00 52.96  ? 403 LEU A N   1 
ATOM   2261 C CA  . LEU A 1 403 ? 128.481 134.968 154.454 1.00 52.96  ? 403 LEU A CA  1 
ATOM   2262 C C   . LEU A 1 403 ? 128.677 136.336 153.815 1.00 52.96  ? 403 LEU A C   1 
ATOM   2263 O O   . LEU A 1 403 ? 127.817 137.217 153.936 1.00 52.96  ? 403 LEU A O   1 
ATOM   2264 C CB  . LEU A 1 403 ? 129.274 134.848 155.758 1.00 52.96  ? 403 LEU A CB  1 
ATOM   2265 C CG  . LEU A 1 403 ? 128.946 135.725 156.972 1.00 52.96  ? 403 LEU A CG  1 
ATOM   2266 C CD1 . LEU A 1 403 ? 129.366 135.005 158.243 1.00 52.96  ? 403 LEU A CD1 1 
ATOM   2267 C CD2 . LEU A 1 403 ? 129.616 137.093 156.909 1.00 52.96  ? 403 LEU A CD2 1 
ATOM   2268 N N   . ILE A 1 404 ? 129.800 136.532 153.123 1.00 52.35  ? 404 ILE A N   1 
ATOM   2269 C CA  . ILE A 1 404 ? 130.072 137.818 152.494 1.00 52.35  ? 404 ILE A CA  1 
ATOM   2270 C C   . ILE A 1 404 ? 129.095 138.079 151.361 1.00 52.35  ? 404 ILE A C   1 
ATOM   2271 O O   . ILE A 1 404 ? 128.639 139.210 151.173 1.00 52.35  ? 404 ILE A O   1 
ATOM   2272 C CB  . ILE A 1 404 ? 131.530 137.879 152.015 1.00 52.35  ? 404 ILE A CB  1 
ATOM   2273 C CG1 . ILE A 1 404 ? 132.454 137.963 153.221 1.00 52.35  ? 404 ILE A CG1 1 
ATOM   2274 C CG2 . ILE A 1 404 ? 131.755 139.065 151.092 1.00 52.35  ? 404 ILE A CG2 1 
ATOM   2275 C CD1 . ILE A 1 404 ? 132.391 139.284 153.948 1.00 52.35  ? 404 ILE A CD1 1 
ATOM   2276 N N   . THR A 1 405 ? 128.759 137.048 150.585 1.00 54.08  ? 405 THR A N   1 
ATOM   2277 C CA  . THR A 1 405 ? 127.810 137.235 149.494 1.00 54.08  ? 405 THR A CA  1 
ATOM   2278 C C   . THR A 1 405 ? 126.443 137.644 150.022 1.00 54.08  ? 405 THR A C   1 
ATOM   2279 O O   . THR A 1 405 ? 125.832 138.592 149.514 1.00 54.08  ? 405 THR A O   1 
ATOM   2280 C CB  . THR A 1 405 ? 127.711 135.962 148.659 1.00 54.08  ? 405 THR A CB  1 
ATOM   2281 O OG1 . THR A 1 405 ? 127.615 134.828 149.526 1.00 54.08  ? 405 THR A OG1 1 
ATOM   2282 C CG2 . THR A 1 405 ? 128.936 135.823 147.777 1.00 54.08  ? 405 THR A CG2 1 
ATOM   2283 N N   . ILE A 1 406 ? 125.956 136.967 151.067 1.00 57.94  ? 406 ILE A N   1 
ATOM   2284 C CA  . ILE A 1 406 ? 124.647 137.342 151.598 1.00 57.94  ? 406 ILE A CA  1 
ATOM   2285 C C   . ILE A 1 406 ? 124.699 138.733 152.232 1.00 57.94  ? 406 ILE A C   1 
ATOM   2286 O O   . ILE A 1 406 ? 123.783 139.549 152.047 1.00 57.94  ? 406 ILE A O   1 
ATOM   2287 C CB  . ILE A 1 406 ? 124.111 136.265 152.567 1.00 57.94  ? 406 ILE A CB  1 
ATOM   2288 C CG1 . ILE A 1 406 ? 122.603 136.429 152.767 1.00 57.94  ? 406 ILE A CG1 1 
ATOM   2289 C CG2 . ILE A 1 406 ? 124.822 136.275 153.909 1.00 57.94  ? 406 ILE A CG2 1 
ATOM   2290 C CD1 . ILE A 1 406 ? 121.894 135.147 153.157 1.00 57.94  ? 406 ILE A CD1 1 
ATOM   2291 N N   . ALA A 1 407 ? 125.790 139.050 152.937 1.00 58.79  ? 407 ALA A N   1 
ATOM   2292 C CA  . ALA A 1 407 ? 125.902 140.349 153.589 1.00 58.79  ? 407 ALA A CA  1 
ATOM   2293 C C   . ALA A 1 407 ? 125.961 141.476 152.567 1.00 58.79  ? 407 ALA A C   1 
ATOM   2294 O O   . ALA A 1 407 ? 125.283 142.498 152.719 1.00 58.79  ? 407 ALA A O   1 
ATOM   2295 C CB  . ALA A 1 407 ? 127.134 140.374 154.492 1.00 58.79  ? 407 ALA A CB  1 
ATOM   2296 N N   . THR A 1 408 ? 126.756 141.304 151.510 1.00 59.74  ? 408 THR A N   1 
ATOM   2297 C CA  . THR A 1 408 ? 126.883 142.356 150.511 1.00 59.74  ? 408 THR A CA  1 
ATOM   2298 C C   . THR A 1 408 ? 125.632 142.460 149.650 1.00 59.74  ? 408 THR A C   1 
ATOM   2299 O O   . THR A 1 408 ? 125.300 143.554 149.188 1.00 59.74  ? 408 THR A O   1 
ATOM   2300 C CB  . THR A 1 408 ? 128.132 142.132 149.651 1.00 59.74  ? 408 THR A CB  1 
ATOM   2301 O OG1 . THR A 1 408 ? 128.476 143.352 148.981 1.00 59.74  ? 408 THR A OG1 1 
ATOM   2302 C CG2 . THR A 1 408 ? 127.917 141.037 148.615 1.00 59.74  ? 408 THR A CG2 1 
ATOM   2303 N N   . PHE A 1 409 ? 124.903 141.356 149.456 1.00 64.30  ? 409 PHE A N   1 
ATOM   2304 C CA  . PHE A 1 409 ? 123.612 141.443 148.785 1.00 64.30  ? 409 PHE A CA  1 
ATOM   2305 C C   . PHE A 1 409 ? 122.642 142.287 149.599 1.00 64.30  ? 409 PHE A C   1 
ATOM   2306 O O   . PHE A 1 409 ? 121.966 143.173 149.061 1.00 64.30  ? 409 PHE A O   1 
ATOM   2307 C CB  . PHE A 1 409 ? 123.052 140.039 148.549 1.00 64.30  ? 409 PHE A CB  1 
ATOM   2308 C CG  . PHE A 1 409 ? 121.582 140.013 148.244 1.00 64.30  ? 409 PHE A CG  1 
ATOM   2309 C CD1 . PHE A 1 409 ? 121.119 140.322 146.977 1.00 64.30  ? 409 PHE A CD1 1 
ATOM   2310 C CD2 . PHE A 1 409 ? 120.664 139.666 149.222 1.00 64.30  ? 409 PHE A CD2 1 
ATOM   2311 C CE1 . PHE A 1 409 ? 119.768 140.297 146.693 1.00 64.30  ? 409 PHE A CE1 1 
ATOM   2312 C CE2 . PHE A 1 409 ? 119.313 139.639 148.944 1.00 64.30  ? 409 PHE A CE2 1 
ATOM   2313 C CZ  . PHE A 1 409 ? 118.864 139.955 147.678 1.00 64.30  ? 409 PHE A CZ  1 
ATOM   2314 N N   . GLN A 1 410 ? 122.582 142.042 150.910 1.00 65.71  ? 410 GLN A N   1 
ATOM   2315 C CA  . GLN A 1 410 ? 121.696 142.834 151.759 1.00 65.71  ? 410 GLN A CA  1 
ATOM   2316 C C   . GLN A 1 410 ? 122.126 144.297 151.809 1.00 65.71  ? 410 GLN A C   1 
ATOM   2317 O O   . GLN A 1 410 ? 121.281 145.200 151.797 1.00 65.71  ? 410 GLN A O   1 
ATOM   2318 C CB  . GLN A 1 410 ? 121.644 142.237 153.163 1.00 65.71  ? 410 GLN A CB  1 
ATOM   2319 C CG  . GLN A 1 410 ? 121.139 140.807 153.217 1.00 65.71  ? 410 GLN A CG  1 
ATOM   2320 C CD  . GLN A 1 410 ? 119.687 140.688 152.809 1.00 65.71  ? 410 GLN A CD  1 
ATOM   2321 O OE1 . GLN A 1 410 ? 118.891 141.600 153.032 1.00 65.71  ? 410 GLN A OE1 1 
ATOM   2322 N NE2 . GLN A 1 410 ? 119.332 139.559 152.210 1.00 65.71  ? 410 GLN A NE2 1 
ATOM   2323 N N   . ILE A 1 411 ? 123.435 144.551 151.867 1.00 66.23  ? 411 ILE A N   1 
ATOM   2324 C CA  . ILE A 1 411 ? 123.929 145.926 151.907 1.00 66.23  ? 411 ILE A CA  1 
ATOM   2325 C C   . ILE A 1 411 ? 123.600 146.652 150.607 1.00 66.23  ? 411 ILE A C   1 
ATOM   2326 O O   . ILE A 1 411 ? 123.147 147.803 150.618 1.00 66.23  ? 411 ILE A O   1 
ATOM   2327 C CB  . ILE A 1 411 ? 125.440 145.947 152.200 1.00 66.23  ? 411 ILE A CB  1 
ATOM   2328 C CG1 . ILE A 1 411 ? 125.712 145.532 153.647 1.00 66.23  ? 411 ILE A CG1 1 
ATOM   2329 C CG2 . ILE A 1 411 ? 126.021 147.327 151.934 1.00 66.23  ? 411 ILE A CG2 1 
ATOM   2330 C CD1 . ILE A 1 411 ? 127.177 145.305 153.948 1.00 66.23  ? 411 ILE A CD1 1 
ATOM   2331 N N   . ALA A 1 412 ? 123.819 145.989 149.466 1.00 68.38  ? 412 ALA A N   1 
ATOM   2332 C CA  . ALA A 1 412 ? 123.511 146.600 148.178 1.00 68.38  ? 412 ALA A CA  1 
ATOM   2333 C C   . ALA A 1 412 ? 122.018 146.855 148.034 1.00 68.38  ? 412 ALA A C   1 
ATOM   2334 O O   . ALA A 1 412 ? 121.607 147.858 147.440 1.00 68.38  ? 412 ALA A O   1 
ATOM   2335 C CB  . ALA A 1 412 ? 124.018 145.713 147.043 1.00 68.38  ? 412 ALA A CB  1 
ATOM   2336 N N   . ALA A 1 413 ? 121.188 145.952 148.561 1.00 70.34  ? 413 ALA A N   1 
ATOM   2337 C CA  . ALA A 1 413 ? 119.752 146.206 148.583 1.00 70.34  ? 413 ALA A CA  1 
ATOM   2338 C C   . ALA A 1 413 ? 119.426 147.421 149.442 1.00 70.34  ? 413 ALA A C   1 
ATOM   2339 O O   . ALA A 1 413 ? 118.543 148.216 149.099 1.00 70.34  ? 413 ALA A O   1 
ATOM   2340 C CB  . ALA A 1 413 ? 119.006 144.972 149.088 1.00 70.34  ? 413 ALA A CB  1 
ATOM   2341 N N   . ASN A 1 414 ? 120.130 147.579 150.565 1.00 73.91  ? 414 ASN A N   1 
ATOM   2342 C CA  . ASN A 1 414 ? 119.855 148.696 151.463 1.00 73.91  ? 414 ASN A CA  1 
ATOM   2343 C C   . ASN A 1 414 ? 120.302 150.027 150.866 1.00 73.91  ? 414 ASN A C   1 
ATOM   2344 O O   . ASN A 1 414 ? 119.594 151.034 150.985 1.00 73.91  ? 414 ASN A O   1 
ATOM   2345 C CB  . ASN A 1 414 ? 120.534 148.459 152.811 1.00 73.91  ? 414 ASN A CB  1 
ATOM   2346 N N   . LEU A 1 415 ? 121.465 150.056 150.225 1.00 72.40  ? 415 LEU A N   1 
ATOM   2347 C CA  . LEU A 1 415 ? 122.057 151.294 149.740 1.00 72.40  ? 415 LEU A CA  1 
ATOM   2348 C C   . LEU A 1 415 ? 121.782 151.492 148.251 1.00 72.40  ? 415 LEU A C   1 
ATOM   2349 O O   . LEU A 1 415 ? 121.292 150.602 147.554 1.00 72.40  ? 415 LEU A O   1 
ATOM   2350 C CB  . LEU A 1 415 ? 123.566 151.307 150.007 1.00 72.40  ? 415 LEU A CB  1 
ATOM   2351 N N   . SER A 1 416 ? 122.100 152.692 147.772 1.00 74.56  ? 416 SER A N   1 
ATOM   2352 C CA  . SER A 1 416 ? 121.936 153.025 146.368 1.00 74.56  ? 416 SER A CA  1 
ATOM   2353 C C   . SER A 1 416 ? 123.188 152.648 145.578 1.00 74.56  ? 416 SER A C   1 
ATOM   2354 O O   . SER A 1 416 ? 124.258 152.391 146.136 1.00 74.56  ? 416 SER A O   1 
ATOM   2355 C CB  . SER A 1 416 ? 121.629 154.513 146.202 1.00 74.56  ? 416 SER A CB  1 
ATOM   2356 N N   . MET A 1 417 ? 123.041 152.621 144.251 1.00 74.16  ? 417 MET A N   1 
ATOM   2357 C CA  . MET A 1 417 ? 124.150 152.227 143.387 1.00 74.16  ? 417 MET A CA  1 
ATOM   2358 C C   . MET A 1 417 ? 125.262 153.269 143.375 1.00 74.16  ? 417 MET A C   1 
ATOM   2359 O O   . MET A 1 417 ? 126.420 152.933 143.101 1.00 74.16  ? 417 MET A O   1 
ATOM   2360 C CB  . MET A 1 417 ? 123.646 151.976 141.966 1.00 74.16  ? 417 MET A CB  1 
ATOM   2361 N N   . GLU A 1 418 ? 124.936 154.530 143.665 1.00 73.85  ? 418 GLU A N   1 
ATOM   2362 C CA  . GLU A 1 418 ? 125.945 155.582 143.647 1.00 73.85  ? 418 GLU A CA  1 
ATOM   2363 C C   . GLU A 1 418 ? 126.880 155.516 144.847 1.00 73.85  ? 418 GLU A C   1 
ATOM   2364 O O   . GLU A 1 418 ? 127.953 156.128 144.812 1.00 73.85  ? 418 GLU A O   1 
ATOM   2365 C CB  . GLU A 1 418 ? 125.272 156.954 143.592 1.00 73.85  ? 418 GLU A CB  1 
ATOM   2366 N N   . ARG A 1 419 ? 126.504 154.793 145.901 1.00 73.24  ? 419 ARG A N   1 
ATOM   2367 C CA  . ARG A 1 419 ? 127.299 154.718 147.120 1.00 73.24  ? 419 ARG A CA  1 
ATOM   2368 C C   . ARG A 1 419 ? 127.899 153.337 147.356 1.00 73.24  ? 419 ARG A C   1 
ATOM   2369 O O   . ARG A 1 419 ? 128.325 153.046 148.479 1.00 73.24  ? 419 ARG A O   1 
ATOM   2370 C CB  . ARG A 1 419 ? 126.452 155.130 148.325 1.00 73.24  ? 419 ARG A CB  1 
ATOM   2371 N N   . TYR A 1 420 ? 127.938 152.480 146.331 1.00 71.95  ? 420 TYR A N   1 
ATOM   2372 C CA  . TYR A 1 420 ? 128.523 151.151 146.495 1.00 71.95  ? 420 TYR A CA  1 
ATOM   2373 C C   . TYR A 1 420 ? 129.978 151.250 146.934 1.00 71.95  ? 420 TYR A C   1 
ATOM   2374 O O   . TYR A 1 420 ? 130.388 150.625 147.921 1.00 71.95  ? 420 TYR A O   1 
ATOM   2375 C CB  . TYR A 1 420 ? 128.420 150.362 145.189 1.00 71.95  ? 420 TYR A CB  1 
ATOM   2376 C CG  . TYR A 1 420 ? 127.042 149.826 144.873 1.00 71.95  ? 420 TYR A CG  1 
ATOM   2377 C CD1 . TYR A 1 420 ? 126.046 149.793 145.838 1.00 71.95  ? 420 TYR A CD1 1 
ATOM   2378 C CD2 . TYR A 1 420 ? 126.741 149.347 143.605 1.00 71.95  ? 420 TYR A CD2 1 
ATOM   2379 C CE1 . TYR A 1 420 ? 124.786 149.302 145.546 1.00 71.95  ? 420 TYR A CE1 1 
ATOM   2380 C CE2 . TYR A 1 420 ? 125.488 148.855 143.304 1.00 71.95  ? 420 TYR A CE2 1 
ATOM   2381 C CZ  . TYR A 1 420 ? 124.513 148.834 144.277 1.00 71.95  ? 420 TYR A CZ  1 
ATOM   2382 O OH  . TYR A 1 420 ? 123.263 148.343 143.979 1.00 71.95  ? 420 TYR A OH  1 
ATOM   2383 N N   . ALA A 1 421 ? 130.770 152.046 146.212 1.00 68.75  ? 421 ALA A N   1 
ATOM   2384 C CA  . ALA A 1 421 ? 132.176 152.213 146.555 1.00 68.75  ? 421 ALA A CA  1 
ATOM   2385 C C   . ALA A 1 421 ? 132.336 152.877 147.915 1.00 68.75  ? 421 ALA A C   1 
ATOM   2386 O O   . ALA A 1 421 ? 133.226 152.510 148.689 1.00 68.75  ? 421 ALA A O   1 
ATOM   2387 C CB  . ALA A 1 421 ? 132.889 153.025 145.474 1.00 68.75  ? 421 ALA A CB  1 
ATOM   2388 N N   . LEU A 1 422 ? 131.477 153.849 148.229 1.00 67.80  ? 422 LEU A N   1 
ATOM   2389 C CA  . LEU A 1 422 ? 131.588 154.546 149.507 1.00 67.80  ? 422 LEU A CA  1 
ATOM   2390 C C   . LEU A 1 422 ? 131.366 153.592 150.676 1.00 67.80  ? 422 LEU A C   1 
ATOM   2391 O O   . LEU A 1 422 ? 132.139 153.588 151.640 1.00 67.80  ? 422 LEU A O   1 
ATOM   2392 C CB  . LEU A 1 422 ? 130.596 155.710 149.557 1.00 67.80  ? 422 LEU A CB  1 
ATOM   2393 C CG  . LEU A 1 422 ? 130.771 156.741 150.677 1.00 67.80  ? 422 LEU A CG  1 
ATOM   2394 C CD1 . LEU A 1 422 ? 130.383 158.124 150.180 1.00 67.80  ? 422 LEU A CD1 1 
ATOM   2395 C CD2 . LEU A 1 422 ? 129.952 156.378 151.908 1.00 67.80  ? 422 LEU A CD2 1 
ATOM   2396 N N   . VAL A 1 423 ? 130.317 152.770 150.607 1.00 66.78  ? 423 VAL A N   1 
ATOM   2397 C CA  . VAL A 1 423 ? 130.053 151.839 151.700 1.00 66.78  ? 423 VAL A CA  1 
ATOM   2398 C C   . VAL A 1 423 ? 131.120 150.751 151.754 1.00 66.78  ? 423 VAL A C   1 
ATOM   2399 O O   . VAL A 1 423 ? 131.598 150.388 152.838 1.00 66.78  ? 423 VAL A O   1 
ATOM   2400 C CB  . VAL A 1 423 ? 128.639 151.244 151.585 1.00 66.78  ? 423 VAL A CB  1 
ATOM   2401 C CG1 . VAL A 1 423 ? 128.324 150.410 152.813 1.00 66.78  ? 423 VAL A CG1 1 
ATOM   2402 C CG2 . VAL A 1 423 ? 127.614 152.354 151.454 1.00 66.78  ? 423 VAL A CG2 1 
ATOM   2403 N N   . PHE A 1 424 ? 131.513 150.213 150.593 1.00 64.50  ? 424 PHE A N   1 
ATOM   2404 C CA  . PHE A 1 424 ? 132.556 149.195 150.564 1.00 64.50  ? 424 PHE A CA  1 
ATOM   2405 C C   . PHE A 1 424 ? 133.905 149.738 151.013 1.00 64.50  ? 424 PHE A C   1 
ATOM   2406 O O   . PHE A 1 424 ? 134.798 148.952 151.346 1.00 64.50  ? 424 PHE A O   1 
ATOM   2407 C CB  . PHE A 1 424 ? 132.673 148.601 149.159 1.00 64.50  ? 424 PHE A CB  1 
ATOM   2408 N N   . GLY A 1 425 ? 134.077 151.056 151.019 1.00 62.76  ? 425 GLY A N   1 
ATOM   2409 C CA  . GLY A 1 425 ? 135.273 151.655 151.565 1.00 62.76  ? 425 GLY A CA  1 
ATOM   2410 C C   . GLY A 1 425 ? 135.171 151.902 153.054 1.00 62.76  ? 425 GLY A C   1 
ATOM   2411 O O   . GLY A 1 425 ? 136.120 151.631 153.789 1.00 62.76  ? 425 GLY A O   1 
ATOM   2412 N N   . VAL A 1 426 ? 134.026 152.411 153.515 1.00 61.73  ? 426 VAL A N   1 
ATOM   2413 C CA  . VAL A 1 426 ? 133.872 152.720 154.935 1.00 61.73  ? 426 VAL A CA  1 
ATOM   2414 C C   . VAL A 1 426 ? 133.900 151.448 155.776 1.00 61.73  ? 426 VAL A C   1 
ATOM   2415 O O   . VAL A 1 426 ? 134.541 151.404 156.838 1.00 61.73  ? 426 VAL A O   1 
ATOM   2416 C CB  . VAL A 1 426 ? 132.586 153.530 155.177 1.00 61.73  ? 426 VAL A CB  1 
ATOM   2417 C CG1 . VAL A 1 426 ? 132.376 153.753 156.664 1.00 61.73  ? 426 VAL A CG1 1 
ATOM   2418 C CG2 . VAL A 1 426 ? 132.663 154.868 154.465 1.00 61.73  ? 426 VAL A CG2 1 
ATOM   2419 N N   . ASN A 1 427 ? 133.201 150.398 155.334 1.00 61.01  ? 427 ASN A N   1 
ATOM   2420 C CA  . ASN A 1 427 ? 133.184 149.174 156.130 1.00 61.01  ? 427 ASN A CA  1 
ATOM   2421 C C   . ASN A 1 427 ? 134.552 148.500 156.132 1.00 61.01  ? 427 ASN A C   1 
ATOM   2422 O O   . ASN A 1 427 ? 134.972 147.944 157.151 1.00 61.01  ? 427 ASN A O   1 
ATOM   2423 C CB  . ASN A 1 427 ? 132.095 148.221 155.636 1.00 61.01  ? 427 ASN A CB  1 
ATOM   2424 C CG  . ASN A 1 427 ? 132.244 147.860 154.178 1.00 61.01  ? 427 ASN A CG  1 
ATOM   2425 O OD1 . ASN A 1 427 ? 133.247 148.179 153.545 1.00 61.01  ? 427 ASN A OD1 1 
ATOM   2426 N ND2 . ASN A 1 427 ? 131.235 147.195 153.630 1.00 61.01  ? 427 ASN A ND2 1 
ATOM   2427 N N   . THR A 1 428 ? 135.271 148.558 155.010 1.00 56.96  ? 428 THR A N   1 
ATOM   2428 C CA  . THR A 1 428 ? 136.639 148.046 154.987 1.00 56.96  ? 428 THR A CA  1 
ATOM   2429 C C   . THR A 1 428 ? 137.551 148.880 155.881 1.00 56.96  ? 428 THR A C   1 
ATOM   2430 O O   . THR A 1 428 ? 138.457 148.344 156.527 1.00 56.96  ? 428 THR A O   1 
ATOM   2431 C CB  . THR A 1 428 ? 137.168 148.017 153.554 1.00 56.96  ? 428 THR A CB  1 
ATOM   2432 O OG1 . THR A 1 428 ? 136.181 147.438 152.693 1.00 56.96  ? 428 THR A OG1 1 
ATOM   2433 C CG2 . THR A 1 428 ? 138.435 147.186 153.476 1.00 56.96  ? 428 THR A CG2 1 
ATOM   2434 N N   . PHE A 1 429 ? 137.323 150.194 155.929 1.00 56.40  ? 429 PHE A N   1 
ATOM   2435 C CA  . PHE A 1 429 ? 138.096 151.068 156.804 1.00 56.40  ? 429 PHE A CA  1 
ATOM   2436 C C   . PHE A 1 429 ? 137.912 150.681 158.265 1.00 56.40  ? 429 PHE A C   1 
ATOM   2437 O O   . PHE A 1 429 ? 138.887 150.547 159.012 1.00 56.40  ? 429 PHE A O   1 
ATOM   2438 C CB  . PHE A 1 429 ? 137.675 152.519 156.563 1.00 56.40  ? 429 PHE A CB  1 
ATOM   2439 C CG  . PHE A 1 429 ? 138.347 153.518 157.463 1.00 56.40  ? 429 PHE A CG  1 
ATOM   2440 C CD1 . PHE A 1 429 ? 139.695 153.423 157.758 1.00 56.40  ? 429 PHE A CD1 1 
ATOM   2441 C CD2 . PHE A 1 429 ? 137.621 154.564 158.008 1.00 56.40  ? 429 PHE A CD2 1 
ATOM   2442 C CE1 . PHE A 1 429 ? 140.301 154.350 158.583 1.00 56.40  ? 429 PHE A CE1 1 
ATOM   2443 C CE2 . PHE A 1 429 ? 138.222 155.490 158.832 1.00 56.40  ? 429 PHE A CE2 1 
ATOM   2444 C CZ  . PHE A 1 429 ? 139.564 155.383 159.120 1.00 56.40  ? 429 PHE A CZ  1 
ATOM   2445 N N   . ILE A 1 430 ? 136.662 150.482 158.688 1.00 54.93  ? 430 ILE A N   1 
ATOM   2446 C CA  . ILE A 1 430 ? 136.434 150.117 160.084 1.00 54.93  ? 430 ILE A CA  1 
ATOM   2447 C C   . ILE A 1 430 ? 136.899 148.687 160.354 1.00 54.93  ? 430 ILE A C   1 
ATOM   2448 O O   . ILE A 1 430 ? 137.357 148.374 161.463 1.00 54.93  ? 430 ILE A O   1 
ATOM   2449 C CB  . ILE A 1 430 ? 134.961 150.344 160.479 1.00 54.93  ? 430 ILE A CB  1 
ATOM   2450 C CG1 . ILE A 1 430 ? 134.812 150.331 162.002 1.00 54.93  ? 430 ILE A CG1 1 
ATOM   2451 C CG2 . ILE A 1 430 ? 134.049 149.316 159.852 1.00 54.93  ? 430 ILE A CG2 1 
ATOM   2452 C CD1 . ILE A 1 430 ? 135.518 151.479 162.693 1.00 54.93  ? 430 ILE A CD1 1 
ATOM   2453 N N   . ALA A 1 431 ? 136.826 147.807 159.349 1.00 51.65  ? 431 ALA A N   1 
ATOM   2454 C CA  . ALA A 1 431 ? 137.353 146.456 159.503 1.00 51.65  ? 431 ALA A CA  1 
ATOM   2455 C C   . ALA A 1 431 ? 138.855 146.474 159.741 1.00 51.65  ? 431 ALA A C   1 
ATOM   2456 O O   . ALA A 1 431 ? 139.357 145.786 160.636 1.00 51.65  ? 431 ALA A O   1 
ATOM   2457 C CB  . ALA A 1 431 ? 137.023 145.624 158.265 1.00 51.65  ? 431 ALA A CB  1 
ATOM   2458 N N   . LEU A 1 432 ? 139.588 147.265 158.956 1.00 48.36  ? 432 LEU A N   1 
ATOM   2459 C CA  . LEU A 1 432 ? 141.025 147.383 159.169 1.00 48.36  ? 432 LEU A CA  1 
ATOM   2460 C C   . LEU A 1 432 ? 141.349 148.094 160.473 1.00 48.36  ? 432 LEU A C   1 
ATOM   2461 O O   . LEU A 1 432 ? 142.356 147.775 161.107 1.00 48.36  ? 432 LEU A O   1 
ATOM   2462 C CB  . LEU A 1 432 ? 141.693 148.097 157.993 1.00 48.36  ? 432 LEU A CB  1 
ATOM   2463 C CG  . LEU A 1 432 ? 142.133 147.228 156.815 1.00 48.36  ? 432 LEU A CG  1 
ATOM   2464 C CD1 . LEU A 1 432 ? 143.207 146.278 157.302 1.00 48.36  ? 432 LEU A CD1 1 
ATOM   2465 C CD2 . LEU A 1 432 ? 140.994 146.457 156.181 1.00 48.36  ? 432 LEU A CD2 1 
ATOM   2466 N N   . ALA A 1 433 ? 140.517 149.050 160.894 1.00 48.90  ? 433 ALA A N   1 
ATOM   2467 C CA  . ALA A 1 433 ? 140.737 149.682 162.190 1.00 48.90  ? 433 ALA A CA  1 
ATOM   2468 C C   . ALA A 1 433 ? 140.641 148.672 163.323 1.00 48.90  ? 433 ALA A C   1 
ATOM   2469 O O   . ALA A 1 433 ? 141.524 148.619 164.190 1.00 48.90  ? 433 ALA A O   1 
ATOM   2470 C CB  . ALA A 1 433 ? 139.733 150.815 162.400 1.00 48.90  ? 433 ALA A CB  1 
ATOM   2471 N N   . LEU A 1 434 ? 139.599 147.839 163.315 1.00 49.12  ? 434 LEU A N   1 
ATOM   2472 C CA  . LEU A 1 434 ? 139.461 146.834 164.362 1.00 49.12  ? 434 LEU A CA  1 
ATOM   2473 C C   . LEU A 1 434 ? 140.549 145.768 164.251 1.00 49.12  ? 434 LEU A C   1 
ATOM   2474 O O   . LEU A 1 434 ? 141.049 145.277 165.272 1.00 49.12  ? 434 LEU A O   1 
ATOM   2475 C CB  . LEU A 1 434 ? 138.066 146.209 164.305 1.00 49.12  ? 434 LEU A CB  1 
ATOM   2476 C CG  . LEU A 1 434 ? 137.594 145.382 165.505 1.00 49.12  ? 434 LEU A CG  1 
ATOM   2477 C CD1 . LEU A 1 434 ? 136.086 145.508 165.646 1.00 49.12  ? 434 LEU A CD1 1 
ATOM   2478 C CD2 . LEU A 1 434 ? 137.992 143.918 165.402 1.00 49.12  ? 434 LEU A CD2 1 
ATOM   2479 N N   . GLN A 1 435 ? 140.930 145.404 163.023 1.00 46.68  ? 435 GLN A N   1 
ATOM   2480 C CA  . GLN A 1 435 ? 141.994 144.423 162.837 1.00 46.68  ? 435 GLN A CA  1 
ATOM   2481 C C   . GLN A 1 435 ? 143.320 144.941 163.368 1.00 46.68  ? 435 GLN A C   1 
ATOM   2482 O O   . GLN A 1 435 ? 144.068 144.200 164.008 1.00 46.68  ? 435 GLN A O   1 
ATOM   2483 C CB  . GLN A 1 435 ? 142.117 144.052 161.360 1.00 46.68  ? 435 GLN A CB  1 
ATOM   2484 C CG  . GLN A 1 435 ? 143.134 142.962 161.084 1.00 46.68  ? 435 GLN A CG  1 
ATOM   2485 C CD  . GLN A 1 435 ? 143.320 142.707 159.606 1.00 46.68  ? 435 GLN A CD  1 
ATOM   2486 O OE1 . GLN A 1 435 ? 142.755 143.407 158.769 1.00 46.68  ? 435 GLN A OE1 1 
ATOM   2487 N NE2 . GLN A 1 435 ? 144.113 141.699 159.276 1.00 46.68  ? 435 GLN A NE2 1 
ATOM   2488 N N   . THR A 1 436 ? 143.627 146.213 163.114 1.00 47.13  ? 436 THR A N   1 
ATOM   2489 C CA  . THR A 1 436 ? 144.851 146.804 163.636 1.00 47.13  ? 436 THR A CA  1 
ATOM   2490 C C   . THR A 1 436 ? 144.809 146.903 165.155 1.00 47.13  ? 436 THR A C   1 
ATOM   2491 O O   . THR A 1 436 ? 145.823 146.671 165.823 1.00 47.13  ? 436 THR A O   1 
ATOM   2492 C CB  . THR A 1 436 ? 145.070 148.177 163.003 1.00 47.13  ? 436 THR A CB  1 
ATOM   2493 O OG1 . THR A 1 436 ? 145.232 148.024 161.588 1.00 47.13  ? 436 THR A OG1 1 
ATOM   2494 C CG2 . THR A 1 436 ? 146.300 148.859 163.570 1.00 47.13  ? 436 THR A CG2 1 
ATOM   2495 N N   . LEU A 1 437 ? 143.648 147.244 165.719 1.00 47.34  ? 437 LEU A N   1 
ATOM   2496 C CA  . LEU A 1 437 ? 143.518 147.248 167.174 1.00 47.34  ? 437 LEU A CA  1 
ATOM   2497 C C   . LEU A 1 437 ? 143.847 145.877 167.753 1.00 47.34  ? 437 LEU A C   1 
ATOM   2498 O O   . LEU A 1 437 ? 144.709 145.747 168.634 1.00 47.34  ? 437 LEU A O   1 
ATOM   2499 C CB  . LEU A 1 437 ? 142.107 147.677 167.572 1.00 47.34  ? 437 LEU A CB  1 
ATOM   2500 C CG  . LEU A 1 437 ? 141.925 148.169 169.007 1.00 47.34  ? 437 LEU A CG  1 
ATOM   2501 C CD1 . LEU A 1 437 ? 142.987 149.194 169.368 1.00 47.34  ? 437 LEU A CD1 1 
ATOM   2502 C CD2 . LEU A 1 437 ? 140.534 148.746 169.192 1.00 47.34  ? 437 LEU A CD2 1 
ATOM   2503 N N   . LEU A 1 438 ? 143.205 144.831 167.230 1.00 45.79  ? 438 LEU A N   1 
ATOM   2504 C CA  . LEU A 1 438 ? 143.443 143.494 167.760 1.00 45.79  ? 438 LEU A CA  1 
ATOM   2505 C C   . LEU A 1 438 ? 144.866 143.028 167.460 1.00 45.79  ? 438 LEU A C   1 
ATOM   2506 O O   . LEU A 1 438 ? 145.437 142.244 168.228 1.00 45.79  ? 438 LEU A O   1 
ATOM   2507 C CB  . LEU A 1 438 ? 142.396 142.528 167.197 1.00 45.79  ? 438 LEU A CB  1 
ATOM   2508 C CG  . LEU A 1 438 ? 142.272 141.087 167.708 1.00 45.79  ? 438 LEU A CG  1 
ATOM   2509 C CD1 . LEU A 1 438 ? 140.845 140.606 167.508 1.00 45.79  ? 438 LEU A CD1 1 
ATOM   2510 C CD2 . LEU A 1 438 ? 143.220 140.136 167.026 1.00 45.79  ? 438 LEU A CD2 1 
ATOM   2511 N N   . THR A 1 439 ? 145.462 143.523 166.372 1.00 43.54  ? 439 THR A N   1 
ATOM   2512 C CA  . THR A 1 439 ? 146.828 143.150 166.019 1.00 43.54  ? 439 THR A CA  1 
ATOM   2513 C C   . THR A 1 439 ? 147.834 143.754 166.989 1.00 43.54  ? 439 THR A C   1 
ATOM   2514 O O   . THR A 1 439 ? 148.779 143.080 167.404 1.00 43.54  ? 439 THR A O   1 
ATOM   2515 C CB  . THR A 1 439 ? 147.133 143.588 164.588 1.00 43.54  ? 439 THR A CB  1 
ATOM   2516 O OG1 . THR A 1 439 ? 146.133 143.068 163.706 1.00 43.54  ? 439 THR A OG1 1 
ATOM   2517 C CG2 . THR A 1 439 ? 148.483 143.069 164.155 1.00 43.54  ? 439 THR A CG2 1 
ATOM   2518 N N   . LEU A 1 440 ? 147.656 145.023 167.359 1.00 45.26  ? 440 LEU A N   1 
ATOM   2519 C CA  . LEU A 1 440 ? 148.480 145.576 168.430 1.00 45.26  ? 440 LEU A CA  1 
ATOM   2520 C C   . LEU A 1 440 ? 148.214 144.887 169.760 1.00 45.26  ? 440 LEU A C   1 
ATOM   2521 O O   . LEU A 1 440 ? 149.110 144.820 170.609 1.00 45.26  ? 440 LEU A O   1 
ATOM   2522 C CB  . LEU A 1 440 ? 148.276 147.086 168.571 1.00 45.26  ? 440 LEU A CB  1 
ATOM   2523 C CG  . LEU A 1 440 ? 149.061 148.031 167.658 1.00 45.26  ? 440 LEU A CG  1 
ATOM   2524 C CD1 . LEU A 1 440 ? 148.592 148.000 166.231 1.00 45.26  ? 440 LEU A CD1 1 
ATOM   2525 C CD2 . LEU A 1 440 ? 148.992 149.447 168.207 1.00 45.26  ? 440 LEU A CD2 1 
ATOM   2526 N N   . ILE A 1 441 ? 146.999 144.379 169.973 1.00 44.74  ? 441 ILE A N   1 
ATOM   2527 C CA  . ILE A 1 441 ? 146.727 143.694 171.235 1.00 44.74  ? 441 ILE A CA  1 
ATOM   2528 C C   . ILE A 1 441 ? 147.479 142.365 171.317 1.00 44.74  ? 441 ILE A C   1 
ATOM   2529 O O   . ILE A 1 441 ? 148.147 142.084 172.317 1.00 44.74  ? 441 ILE A O   1 
ATOM   2530 C CB  . ILE A 1 441 ? 145.215 143.506 171.445 1.00 44.74  ? 441 ILE A CB  1 
ATOM   2531 C CG1 . ILE A 1 441 ? 144.525 144.864 171.558 1.00 44.74  ? 441 ILE A CG1 1 
ATOM   2532 C CG2 . ILE A 1 441 ? 144.955 142.691 172.697 1.00 44.74  ? 441 ILE A CG2 1 
ATOM   2533 C CD1 . ILE A 1 441 ? 143.019 144.793 171.508 1.00 44.74  ? 441 ILE A CD1 1 
ATOM   2534 N N   . VAL A 1 442 ? 147.401 141.532 170.276 1.00 46.16  ? 442 VAL A N   1 
ATOM   2535 C CA  . VAL A 1 442 ? 147.835 140.144 170.411 1.00 46.16  ? 442 VAL A CA  1 
ATOM   2536 C C   . VAL A 1 442 ? 149.006 139.754 169.510 1.00 46.16  ? 442 VAL A C   1 
ATOM   2537 O O   . VAL A 1 442 ? 149.676 138.752 169.805 1.00 46.16  ? 442 VAL A O   1 
ATOM   2538 C CB  . VAL A 1 442 ? 146.667 139.160 170.188 1.00 46.16  ? 442 VAL A CB  1 
ATOM   2539 C CG1 . VAL A 1 442 ? 145.570 139.368 171.223 1.00 46.16  ? 442 VAL A CG1 1 
ATOM   2540 C CG2 . VAL A 1 442 ? 146.144 139.255 168.780 1.00 46.16  ? 442 VAL A CG2 1 
ATOM   2541 N N   . VAL A 1 443 ? 149.276 140.483 168.434 1.00 44.52  ? 443 VAL A N   1 
ATOM   2542 C CA  . VAL A 1 443 ? 150.223 140.055 167.410 1.00 44.52  ? 443 VAL A CA  1 
ATOM   2543 C C   . VAL A 1 443 ? 151.525 140.846 167.479 1.00 44.52  ? 443 VAL A C   1 
ATOM   2544 O O   . VAL A 1 443 ? 152.612 140.269 167.421 1.00 44.52  ? 443 VAL A O   1 
ATOM   2545 C CB  . VAL A 1 443 ? 149.597 140.154 166.002 1.00 44.52  ? 443 VAL A CB  1 
ATOM   2546 C CG1 . VAL A 1 443 ? 150.627 139.804 164.948 1.00 44.52  ? 443 VAL A CG1 1 
ATOM   2547 C CG2 . VAL A 1 443 ? 148.384 139.254 165.885 1.00 44.52  ? 443 VAL A CG2 1 
ATOM   2548 N N   . ASP A 1 444 ? 151.432 142.169 167.595 1.00 47.47  ? 444 ASP A N   1 
ATOM   2549 C CA  . ASP A 1 444 ? 152.602 143.025 167.438 1.00 47.47  ? 444 ASP A CA  1 
ATOM   2550 C C   . ASP A 1 444 ? 153.633 142.772 168.531 1.00 47.47  ? 444 ASP A C   1 
ATOM   2551 O O   . ASP A 1 444 ? 153.292 142.593 169.703 1.00 47.47  ? 444 ASP A O   1 
ATOM   2552 C CB  . ASP A 1 444 ? 152.191 144.493 167.449 1.00 47.47  ? 444 ASP A CB  1 
ATOM   2553 C CG  . ASP A 1 444 ? 153.208 145.382 166.767 1.00 47.47  ? 444 ASP A CG  1 
ATOM   2554 O OD1 . ASP A 1 444 ? 154.199 144.846 166.229 1.00 47.47  ? 444 ASP A OD1 1 
ATOM   2555 O OD2 . ASP A 1 444 ? 153.020 146.616 166.768 1.00 47.47  ? 444 ASP A OD2 1 
ATOM   2556 N N   . ALA A 1 445 ? 154.908 142.765 168.131 1.00 46.92  ? 445 ALA A N   1 
ATOM   2557 C CA  . ALA A 1 445 ? 155.989 142.507 169.077 1.00 46.92  ? 445 ALA A CA  1 
ATOM   2558 C C   . ALA A 1 445 ? 156.061 143.590 170.144 1.00 46.92  ? 445 ALA A C   1 
ATOM   2559 O O   . ALA A 1 445 ? 156.327 143.301 171.316 1.00 46.92  ? 445 ALA A O   1 
ATOM   2560 C CB  . ALA A 1 445 ? 157.319 142.397 168.336 1.00 46.92  ? 445 ALA A CB  1 
ATOM   2561 N N   . SER A 1 446 ? 155.838 144.847 169.755 1.00 51.99  ? 446 SER A N   1 
ATOM   2562 C CA  . SER A 1 446 ? 155.786 145.930 170.730 1.00 51.99  ? 446 SER A CA  1 
ATOM   2563 C C   . SER A 1 446 ? 154.587 145.807 171.660 1.00 51.99  ? 446 SER A C   1 
ATOM   2564 O O   . SER A 1 446 ? 154.601 146.389 172.749 1.00 51.99  ? 446 SER A O   1 
ATOM   2565 C CB  . SER A 1 446 ? 155.759 147.281 170.016 1.00 51.99  ? 446 SER A CB  1 
ATOM   2566 O OG  . SER A 1 446 ? 156.996 147.541 169.375 1.00 51.99  ? 446 SER A OG  1 
ATOM   2567 N N   . GLY A 1 447 ? 153.556 145.068 171.257 1.00 49.48  ? 447 GLY A N   1 
ATOM   2568 C CA  . GLY A 1 447 ? 152.418 144.815 172.117 1.00 49.48  ? 447 GLY A CA  1 
ATOM   2569 C C   . GLY A 1 447 ? 152.641 143.601 172.992 1.00 49.48  ? 447 GLY A C   1 
ATOM   2570 O O   . GLY A 1 447 ? 153.643 143.528 173.710 1.00 49.48  ? 447 GLY A O   1 
ATOM   2571 N N   . LEU A 1 448 ? 151.718 142.642 172.949 1.00 50.37  ? 448 LEU A N   1 
ATOM   2572 C CA  . LEU A 1 448 ? 151.891 141.409 173.705 1.00 50.37  ? 448 LEU A CA  1 
ATOM   2573 C C   . LEU A 1 448 ? 152.630 140.338 172.915 1.00 50.37  ? 448 LEU A C   1 
ATOM   2574 O O   . LEU A 1 448 ? 153.305 139.495 173.517 1.00 50.37  ? 448 LEU A O   1 
ATOM   2575 C CB  . LEU A 1 448 ? 150.534 140.872 174.165 1.00 50.37  ? 448 LEU A CB  1 
ATOM   2576 C CG  . LEU A 1 448 ? 149.816 141.755 175.188 1.00 50.37  ? 448 LEU A CG  1 
ATOM   2577 C CD1 . LEU A 1 448 ? 148.398 141.266 175.436 1.00 50.37  ? 448 LEU A CD1 1 
ATOM   2578 C CD2 . LEU A 1 448 ? 150.603 141.822 176.487 1.00 50.37  ? 448 LEU A CD2 1 
ATOM   2579 N N   . GLY A 1 449 ? 152.522 140.359 171.588 1.00 48.23  ? 449 GLY A N   1 
ATOM   2580 C CA  . GLY A 1 449 ? 153.283 139.465 170.739 1.00 48.23  ? 449 GLY A CA  1 
ATOM   2581 C C   . GLY A 1 449 ? 153.043 137.997 171.012 1.00 48.23  ? 449 GLY A C   1 
ATOM   2582 O O   . GLY A 1 449 ? 153.997 137.221 171.126 1.00 48.23  ? 449 GLY A O   1 
ATOM   2583 N N   . LEU A 1 450 ? 151.777 137.606 171.130 1.00 44.13  ? 450 LEU A N   1 
ATOM   2584 C CA  . LEU A 1 450 ? 151.451 136.220 171.435 1.00 44.13  ? 450 LEU A CA  1 
ATOM   2585 C C   . LEU A 1 450 ? 151.873 135.308 170.289 1.00 44.13  ? 450 LEU A C   1 
ATOM   2586 O O   . LEU A 1 450 ? 151.916 135.712 169.125 1.00 44.13  ? 450 LEU A O   1 
ATOM   2587 C CB  . LEU A 1 450 ? 149.954 136.069 171.708 1.00 44.13  ? 450 LEU A CB  1 
ATOM   2588 C CG  . LEU A 1 450 ? 149.306 137.115 172.621 1.00 44.13  ? 450 LEU A CG  1 
ATOM   2589 C CD1 . LEU A 1 450 ? 147.828 136.825 172.805 1.00 44.13  ? 450 LEU A CD1 1 
ATOM   2590 C CD2 . LEU A 1 450 ? 150.011 137.179 173.966 1.00 44.13  ? 450 LEU A CD2 1 
ATOM   2591 N N   . GLU A 1 451 ? 152.197 134.066 170.636 1.00 41.95  ? 451 GLU A N   1 
ATOM   2592 C CA  . GLU A 1 451 ? 152.663 133.103 169.651 1.00 41.95  ? 451 GLU A CA  1 
ATOM   2593 C C   . GLU A 1 451 ? 151.570 132.819 168.624 1.00 41.95  ? 451 GLU A C   1 
ATOM   2594 O O   . GLU A 1 451 ? 150.378 133.023 168.869 1.00 41.95  ? 451 GLU A O   1 
ATOM   2595 C CB  . GLU A 1 451 ? 153.099 131.810 170.341 1.00 41.95  ? 451 GLU A CB  1 
ATOM   2596 C CG  . GLU A 1 451 ? 154.006 130.920 169.508 1.00 41.95  ? 451 GLU A CG  1 
ATOM   2597 C CD  . GLU A 1 451 ? 154.294 129.594 170.180 1.00 41.95  ? 451 GLU A CD  1 
ATOM   2598 O OE1 . GLU A 1 451 ? 153.845 129.399 171.329 1.00 41.95  ? 451 GLU A OE1 1 
ATOM   2599 O OE2 . GLU A 1 451 ? 154.961 128.743 169.557 1.00 41.95  ? 451 GLU A OE2 1 
ATOM   2600 N N   . ILE A 1 452 ? 151.996 132.356 167.447 1.00 41.96  ? 452 ILE A N   1 
ATOM   2601 C CA  . ILE A 1 452 ? 151.054 132.122 166.357 1.00 41.96  ? 452 ILE A CA  1 
ATOM   2602 C C   . ILE A 1 452 ? 150.103 130.980 166.700 1.00 41.96  ? 452 ILE A C   1 
ATOM   2603 O O   . ILE A 1 452 ? 148.919 131.013 166.342 1.00 41.96  ? 452 ILE A O   1 
ATOM   2604 C CB  . ILE A 1 452 ? 151.813 131.871 165.041 1.00 41.96  ? 452 ILE A CB  1 
ATOM   2605 C CG1 . ILE A 1 452 ? 150.835 131.558 163.911 1.00 41.96  ? 452 ILE A CG1 1 
ATOM   2606 C CG2 . ILE A 1 452 ? 152.836 130.756 165.205 1.00 41.96  ? 452 ILE A CG2 1 
ATOM   2607 C CD1 . ILE A 1 452 ? 151.426 131.734 162.546 1.00 41.96  ? 452 ILE A CD1 1 
ATOM   2608 N N   . THR A 1 453 ? 150.592 129.959 167.407 1.00 42.27  ? 453 THR A N   1 
ATOM   2609 C CA  . THR A 1 453 ? 149.719 128.866 167.814 1.00 42.27  ? 453 THR A CA  1 
ATOM   2610 C C   . THR A 1 453 ? 148.726 129.289 168.884 1.00 42.27  ? 453 THR A C   1 
ATOM   2611 O O   . THR A 1 453 ? 147.727 128.593 169.091 1.00 42.27  ? 453 THR A O   1 
ATOM   2612 C CB  . THR A 1 453 ? 150.539 127.683 168.326 1.00 42.27  ? 453 THR A CB  1 
ATOM   2613 O OG1 . THR A 1 453 ? 149.670 126.569 168.557 1.00 42.27  ? 453 THR A OG1 1 
ATOM   2614 C CG2 . THR A 1 453 ? 151.239 128.041 169.624 1.00 42.27  ? 453 THR A CG2 1 
ATOM   2615 N N   . THR A 1 454 ? 148.976 130.404 169.568 1.00 39.50  ? 454 THR A N   1 
ATOM   2616 C CA  . THR A 1 454 ? 148.076 130.878 170.611 1.00 39.50  ? 454 THR A CA  1 
ATOM   2617 C C   . THR A 1 454 ? 147.040 131.856 170.074 1.00 39.50  ? 454 THR A C   1 
ATOM   2618 O O   . THR A 1 454 ? 145.873 131.792 170.470 1.00 39.50  ? 454 THR A O   1 
ATOM   2619 C CB  . THR A 1 454 ? 148.876 131.531 171.742 1.00 39.50  ? 454 THR A CB  1 
ATOM   2620 O OG1 . THR A 1 454 ? 149.739 130.556 172.340 1.00 39.50  ? 454 THR A OG1 1 
ATOM   2621 C CG2 . THR A 1 454 ? 147.948 132.079 172.808 1.00 39.50  ? 454 THR A CG2 1 
ATOM   2622 N N   . GLN A 1 455 ? 147.432 132.745 169.158 1.00 41.34  ? 455 GLN A N   1 
ATOM   2623 C CA  . GLN A 1 455 ? 146.495 133.733 168.635 1.00 41.34  ? 455 GLN A CA  1 
ATOM   2624 C C   . GLN A 1 455 ? 145.361 133.097 167.842 1.00 41.34  ? 455 GLN A C   1 
ATOM   2625 O O   . GLN A 1 455 ? 144.290 133.701 167.726 1.00 41.34  ? 455 GLN A O   1 
ATOM   2626 C CB  . GLN A 1 455 ? 147.224 134.754 167.760 1.00 41.34  ? 455 GLN A CB  1 
ATOM   2627 C CG  . GLN A 1 455 ? 148.096 134.139 166.690 1.00 41.34  ? 455 GLN A CG  1 
ATOM   2628 C CD  . GLN A 1 455 ? 148.879 135.175 165.917 1.00 41.34  ? 455 GLN A CD  1 
ATOM   2629 O OE1 . GLN A 1 455 ? 149.267 136.206 166.460 1.00 41.34  ? 455 GLN A OE1 1 
ATOM   2630 N NE2 . GLN A 1 455 ? 149.112 134.907 164.639 1.00 41.34  ? 455 GLN A NE2 1 
ATOM   2631 N N   . PHE A 1 456 ? 145.571 131.900 167.293 1.00 42.44  ? 456 PHE A N   1 
ATOM   2632 C CA  . PHE A 1 456 ? 144.490 131.191 166.620 1.00 42.44  ? 456 PHE A CA  1 
ATOM   2633 C C   . PHE A 1 456 ? 143.445 130.673 167.598 1.00 42.44  ? 456 PHE A C   1 
ATOM   2634 O O   . PHE A 1 456 ? 142.294 130.467 167.199 1.00 42.44  ? 456 PHE A O   1 
ATOM   2635 C CB  . PHE A 1 456 ? 145.063 130.050 165.785 1.00 42.44  ? 456 PHE A CB  1 
ATOM   2636 C CG  . PHE A 1 456 ? 145.259 130.399 164.337 1.00 42.44  ? 456 PHE A CG  1 
ATOM   2637 C CD1 . PHE A 1 456 ? 146.514 130.345 163.761 1.00 42.44  ? 456 PHE A CD1 1 
ATOM   2638 C CD2 . PHE A 1 456 ? 144.179 130.747 163.544 1.00 42.44  ? 456 PHE A CD2 1 
ATOM   2639 C CE1 . PHE A 1 456 ? 146.692 130.658 162.427 1.00 42.44  ? 456 PHE A CE1 1 
ATOM   2640 C CE2 . PHE A 1 456 ? 144.352 131.059 162.209 1.00 42.44  ? 456 PHE A CE2 1 
ATOM   2641 C CZ  . PHE A 1 456 ? 145.608 131.013 161.651 1.00 42.44  ? 456 PHE A CZ  1 
ATOM   2642 N N   . LEU A 1 457 ? 143.817 130.453 168.862 1.00 42.42  ? 457 LEU A N   1 
ATOM   2643 C CA  . LEU A 1 457 ? 142.815 130.174 169.886 1.00 42.42  ? 457 LEU A CA  1 
ATOM   2644 C C   . LEU A 1 457 ? 141.917 131.383 170.111 1.00 42.42  ? 457 LEU A C   1 
ATOM   2645 O O   . LEU A 1 457 ? 140.708 131.234 170.323 1.00 42.42  ? 457 LEU A O   1 
ATOM   2646 C CB  . LEU A 1 457 ? 143.493 129.751 171.189 1.00 42.42  ? 457 LEU A CB  1 
ATOM   2647 C CG  . LEU A 1 457 ? 144.303 128.453 171.155 1.00 42.42  ? 457 LEU A CG  1 
ATOM   2648 C CD1 . LEU A 1 457 ? 145.152 128.307 172.404 1.00 42.42  ? 457 LEU A CD1 1 
ATOM   2649 C CD2 . LEU A 1 457 ? 143.388 127.253 170.995 1.00 42.42  ? 457 LEU A CD2 1 
ATOM   2650 N N   . ILE A 1 458 ? 142.490 132.589 170.079 1.00 44.67  ? 458 ILE A N   1 
ATOM   2651 C CA  . ILE A 1 458 ? 141.674 133.800 170.139 1.00 44.67  ? 458 ILE A CA  1 
ATOM   2652 C C   . ILE A 1 458 ? 140.786 133.905 168.907 1.00 44.67  ? 458 ILE A C   1 
ATOM   2653 O O   . ILE A 1 458 ? 139.594 134.217 169.013 1.00 44.67  ? 458 ILE A O   1 
ATOM   2654 C CB  . ILE A 1 458 ? 142.552 135.057 170.313 1.00 44.67  ? 458 ILE A CB  1 
ATOM   2655 C CG1 . ILE A 1 458 ? 143.276 135.057 171.664 1.00 44.67  ? 458 ILE A CG1 1 
ATOM   2656 C CG2 . ILE A 1 458 ? 141.719 136.320 170.171 1.00 44.67  ? 458 ILE A CG2 1 
ATOM   2657 C CD1 . ILE A 1 458 ? 144.634 134.416 171.665 1.00 44.67  ? 458 ILE A CD1 1 
ATOM   2658 N N   . TYR A 1 459 ? 141.343 133.631 167.723 1.00 46.33  ? 459 TYR A N   1 
ATOM   2659 C CA  . TYR A 1 459 ? 140.573 133.771 166.489 1.00 46.33  ? 459 TYR A CA  1 
ATOM   2660 C C   . TYR A 1 459 ? 139.374 132.833 166.477 1.00 46.33  ? 459 TYR A C   1 
ATOM   2661 O O   . TYR A 1 459 ? 138.287 133.210 166.023 1.00 46.33  ? 459 TYR A O   1 
ATOM   2662 C CB  . TYR A 1 459 ? 141.460 133.510 165.271 1.00 46.33  ? 459 TYR A CB  1 
ATOM   2663 C CG  . TYR A 1 459 ? 142.672 134.408 165.169 1.00 46.33  ? 459 TYR A CG  1 
ATOM   2664 C CD1 . TYR A 1 459 ? 142.678 135.670 165.745 1.00 46.33  ? 459 TYR A CD1 1 
ATOM   2665 C CD2 . TYR A 1 459 ? 143.808 133.995 164.489 1.00 46.33  ? 459 TYR A CD2 1 
ATOM   2666 C CE1 . TYR A 1 459 ? 143.782 136.487 165.655 1.00 46.33  ? 459 TYR A CE1 1 
ATOM   2667 C CE2 . TYR A 1 459 ? 144.917 134.807 164.391 1.00 46.33  ? 459 TYR A CE2 1 
ATOM   2668 C CZ  . TYR A 1 459 ? 144.899 136.051 164.975 1.00 46.33  ? 459 TYR A CZ  1 
ATOM   2669 O OH  . TYR A 1 459 ? 146.002 136.868 164.880 1.00 46.33  ? 459 TYR A OH  1 
ATOM   2670 N N   . ALA A 1 460 ? 139.552 131.604 166.963 1.00 48.48  ? 460 ALA A N   1 
ATOM   2671 C CA  . ALA A 1 460 ? 138.415 130.704 167.112 1.00 48.48  ? 460 ALA A CA  1 
ATOM   2672 C C   . ALA A 1 460 ? 137.393 131.272 168.086 1.00 48.48  ? 460 ALA A C   1 
ATOM   2673 O O   . ALA A 1 460 ? 136.186 131.251 167.815 1.00 48.48  ? 460 ALA A O   1 
ATOM   2674 C CB  . ALA A 1 460 ? 138.893 129.330 167.576 1.00 48.48  ? 460 ALA A CB  1 
ATOM   2675 N N   . SER A 1 461 ? 137.858 131.794 169.223 1.00 48.11  ? 461 SER A N   1 
ATOM   2676 C CA  . SER A 1 461 ? 136.946 132.426 170.170 1.00 48.11  ? 461 SER A CA  1 
ATOM   2677 C C   . SER A 1 461 ? 136.431 133.756 169.643 1.00 48.11  ? 461 SER A C   1 
ATOM   2678 O O   . SER A 1 461 ? 135.329 134.182 170.005 1.00 48.11  ? 461 SER A O   1 
ATOM   2679 C CB  . SER A 1 461 ? 137.637 132.622 171.518 1.00 48.11  ? 461 SER A CB  1 
ATOM   2680 O OG  . SER A 1 461 ? 136.975 133.613 172.284 1.00 48.11  ? 461 SER A OG  1 
ATOM   2681 N N   . TYR A 1 462 ? 137.216 134.429 168.799 1.00 47.37  ? 462 TYR A N   1 
ATOM   2682 C CA  . TYR A 1 462 ? 136.762 135.677 168.197 1.00 47.37  ? 462 TYR A CA  1 
ATOM   2683 C C   . TYR A 1 462 ? 135.575 135.449 167.267 1.00 47.37  ? 462 TYR A C   1 
ATOM   2684 O O   . TYR A 1 462 ? 134.598 136.206 167.302 1.00 47.37  ? 462 TYR A O   1 
ATOM   2685 C CB  . TYR A 1 462 ? 137.919 136.340 167.455 1.00 47.37  ? 462 TYR A CB  1 
ATOM   2686 C CG  . TYR A 1 462 ? 137.476 137.245 166.346 1.00 47.37  ? 462 TYR A CG  1 
ATOM   2687 C CD1 . TYR A 1 462 ? 136.829 138.444 166.607 1.00 47.37  ? 462 TYR A CD1 1 
ATOM   2688 C CD2 . TYR A 1 462 ? 137.686 136.885 165.030 1.00 47.37  ? 462 TYR A CD2 1 
ATOM   2689 C CE1 . TYR A 1 462 ? 136.418 139.258 165.581 1.00 47.37  ? 462 TYR A CE1 1 
ATOM   2690 C CE2 . TYR A 1 462 ? 137.279 137.686 164.009 1.00 47.37  ? 462 TYR A CE2 1 
ATOM   2691 C CZ  . TYR A 1 462 ? 136.648 138.870 164.281 1.00 47.37  ? 462 TYR A CZ  1 
ATOM   2692 O OH  . TYR A 1 462 ? 136.252 139.658 163.232 1.00 47.37  ? 462 TYR A OH  1 
ATOM   2693 N N   . PHE A 1 463 ? 135.639 134.418 166.421 1.00 46.76  ? 463 PHE A N   1 
ATOM   2694 C CA  . PHE A 1 463 ? 134.462 134.055 165.640 1.00 46.76  ? 463 PHE A CA  1 
ATOM   2695 C C   . PHE A 1 463 ? 133.372 133.438 166.503 1.00 46.76  ? 463 PHE A C   1 
ATOM   2696 O O   . PHE A 1 463 ? 132.195 133.510 166.137 1.00 46.76  ? 463 PHE A O   1 
ATOM   2697 C CB  . PHE A 1 463 ? 134.822 133.096 164.506 1.00 46.76  ? 463 PHE A CB  1 
ATOM   2698 C CG  . PHE A 1 463 ? 135.496 133.754 163.339 1.00 46.76  ? 463 PHE A CG  1 
ATOM   2699 C CD1 . PHE A 1 463 ? 134.766 134.533 162.460 1.00 46.76  ? 463 PHE A CD1 1 
ATOM   2700 C CD2 . PHE A 1 463 ? 136.841 133.559 163.093 1.00 46.76  ? 463 PHE A CD2 1 
ATOM   2701 C CE1 . PHE A 1 463 ? 135.371 135.128 161.378 1.00 46.76  ? 463 PHE A CE1 1 
ATOM   2702 C CE2 . PHE A 1 463 ? 137.449 134.153 162.008 1.00 46.76  ? 463 PHE A CE2 1 
ATOM   2703 C CZ  . PHE A 1 463 ? 136.712 134.936 161.151 1.00 46.76  ? 463 PHE A CZ  1 
ATOM   2704 N N   . ALA A 1 464 ? 133.730 132.828 167.631 1.00 53.06  ? 464 ALA A N   1 
ATOM   2705 C CA  . ALA A 1 464 ? 132.711 132.407 168.581 1.00 53.06  ? 464 ALA A CA  1 
ATOM   2706 C C   . ALA A 1 464 ? 132.074 133.601 169.277 1.00 53.06  ? 464 ALA A C   1 
ATOM   2707 O O   . ALA A 1 464 ? 130.924 133.514 169.720 1.00 53.06  ? 464 ALA A O   1 
ATOM   2708 C CB  . ALA A 1 464 ? 133.308 131.448 169.611 1.00 53.06  ? 464 ALA A CB  1 
ATOM   2709 N N   . LEU A 1 465 ? 132.800 134.718 169.380 1.00 54.77  ? 465 LEU A N   1 
ATOM   2710 C CA  . LEU A 1 465 ? 132.230 135.919 169.981 1.00 54.77  ? 465 LEU A CA  1 
ATOM   2711 C C   . LEU A 1 465 ? 131.234 136.592 169.045 1.00 54.77  ? 465 LEU A C   1 
ATOM   2712 O O   . LEU A 1 465 ? 130.162 137.027 169.483 1.00 54.77  ? 465 LEU A O   1 
ATOM   2713 C CB  . LEU A 1 465 ? 133.342 136.889 170.370 1.00 54.77  ? 465 LEU A CB  1 
ATOM   2714 C CG  . LEU A 1 465 ? 132.880 138.166 171.072 1.00 54.77  ? 465 LEU A CG  1 
ATOM   2715 C CD1 . LEU A 1 465 ? 132.207 137.833 172.394 1.00 54.77  ? 465 LEU A CD1 1 
ATOM   2716 C CD2 . LEU A 1 465 ? 134.054 139.107 171.287 1.00 54.77  ? 465 LEU A CD2 1 
ATOM   2717 N N   . ILE A 1 466 ? 131.565 136.694 167.754 1.00 57.63  ? 466 ILE A N   1 
ATOM   2718 C CA  . ILE A 1 466 ? 130.586 137.202 166.797 1.00 57.63  ? 466 ILE A CA  1 
ATOM   2719 C C   . ILE A 1 466 ? 129.441 136.213 166.626 1.00 57.63  ? 466 ILE A C   1 
ATOM   2720 O O   . ILE A 1 466 ? 128.319 136.606 166.281 1.00 57.63  ? 466 ILE A O   1 
ATOM   2721 C CB  . ILE A 1 466 ? 131.248 137.553 165.448 1.00 57.63  ? 466 ILE A CB  1 
ATOM   2722 C CG1 . ILE A 1 466 ? 130.262 138.309 164.550 1.00 57.63  ? 466 ILE A CG1 1 
ATOM   2723 C CG2 . ILE A 1 466 ? 131.780 136.326 164.756 1.00 57.63  ? 466 ILE A CG2 1 
ATOM   2724 C CD1 . ILE A 1 466 ? 130.885 138.966 163.344 1.00 57.63  ? 466 ILE A CD1 1 
ATOM   2725 N N   . ALA A 1 467 ? 129.690 134.925 166.870 1.00 59.22  ? 467 ALA A N   1 
ATOM   2726 C CA  . ALA A 1 467 ? 128.610 133.946 166.808 1.00 59.22  ? 467 ALA A CA  1 
ATOM   2727 C C   . ALA A 1 467 ? 127.530 134.256 167.834 1.00 59.22  ? 467 ALA A C   1 
ATOM   2728 O O   . ALA A 1 467 ? 126.334 134.178 167.532 1.00 59.22  ? 467 ALA A O   1 
ATOM   2729 C CB  . ALA A 1 467 ? 129.162 132.537 167.022 1.00 59.22  ? 467 ALA A CB  1 
ATOM   2730 N N   . VAL A 1 468 ? 127.934 134.622 169.052 1.00 63.92  ? 468 VAL A N   1 
ATOM   2731 C CA  . VAL A 1 468 ? 126.967 134.877 170.114 1.00 63.92  ? 468 VAL A CA  1 
ATOM   2732 C C   . VAL A 1 468 ? 126.185 136.159 169.845 1.00 63.92  ? 468 VAL A C   1 
ATOM   2733 O O   . VAL A 1 468 ? 124.958 136.192 169.994 1.00 63.92  ? 468 VAL A O   1 
ATOM   2734 C CB  . VAL A 1 468 ? 127.680 134.919 171.477 1.00 63.92  ? 468 VAL A CB  1 
ATOM   2735 C CG1 . VAL A 1 468 ? 126.715 135.342 172.569 1.00 63.92  ? 468 VAL A CG1 1 
ATOM   2736 C CG2 . VAL A 1 468 ? 128.292 133.563 171.793 1.00 63.92  ? 468 VAL A CG2 1 
ATOM   2737 N N   . VAL A 1 469 ? 126.874 137.232 169.447 1.00 68.06  ? 469 VAL A N   1 
ATOM   2738 C CA  . VAL A 1 469 ? 126.193 138.512 169.266 1.00 68.06  ? 469 VAL A CA  1 
ATOM   2739 C C   . VAL A 1 469 ? 125.252 138.457 168.066 1.00 68.06  ? 469 VAL A C   1 
ATOM   2740 O O   . VAL A 1 469 ? 124.161 139.040 168.092 1.00 68.06  ? 469 VAL A O   1 
ATOM   2741 C CB  . VAL A 1 469 ? 127.212 139.665 169.152 1.00 68.06  ? 469 VAL A CB  1 
ATOM   2742 C CG1 . VAL A 1 469 ? 128.123 139.488 167.953 1.00 68.06  ? 469 VAL A CG1 1 
ATOM   2743 C CG2 . VAL A 1 469 ? 126.495 141.009 169.090 1.00 68.06  ? 469 VAL A CG2 1 
ATOM   2744 N N   . PHE A 1 470 ? 125.651 137.758 167.000 1.00 67.31  ? 470 PHE A N   1 
ATOM   2745 C CA  . PHE A 1 470 ? 124.744 137.555 165.875 1.00 67.31  ? 470 PHE A CA  1 
ATOM   2746 C C   . PHE A 1 470 ? 123.544 136.717 166.294 1.00 67.31  ? 470 PHE A C   1 
ATOM   2747 O O   . PHE A 1 470 ? 122.409 136.993 165.888 1.00 67.31  ? 470 PHE A O   1 
ATOM   2748 C CB  . PHE A 1 470 ? 125.484 136.895 164.713 1.00 67.31  ? 470 PHE A CB  1 
ATOM   2749 N N   . LEU A 1 471 ? 123.781 135.686 167.107 1.00 69.86  ? 471 LEU A N   1 
ATOM   2750 C CA  . LEU A 1 471 ? 122.680 134.910 167.665 1.00 69.86  ? 471 LEU A CA  1 
ATOM   2751 C C   . LEU A 1 471 ? 121.815 135.765 168.582 1.00 69.86  ? 471 LEU A C   1 
ATOM   2752 O O   . LEU A 1 471 ? 120.583 135.670 168.552 1.00 69.86  ? 471 LEU A O   1 
ATOM   2753 C CB  . LEU A 1 471 ? 123.230 133.697 168.416 1.00 69.86  ? 471 LEU A CB  1 
ATOM   2754 C CG  . LEU A 1 471 ? 122.228 132.698 168.993 1.00 69.86  ? 471 LEU A CG  1 
ATOM   2755 C CD1 . LEU A 1 471 ? 121.426 132.054 167.883 1.00 69.86  ? 471 LEU A CD1 1 
ATOM   2756 C CD2 . LEU A 1 471 ? 122.946 131.642 169.818 1.00 69.86  ? 471 LEU A CD2 1 
ATOM   2757 N N   . ALA A 1 472 ? 122.445 136.608 169.406 1.00 72.85  ? 472 ALA A N   1 
ATOM   2758 C CA  . ALA A 1 472 ? 121.692 137.482 170.300 1.00 72.85  ? 472 ALA A CA  1 
ATOM   2759 C C   . ALA A 1 472 ? 120.895 138.518 169.516 1.00 72.85  ? 472 ALA A C   1 
ATOM   2760 O O   . ALA A 1 472 ? 119.721 138.769 169.813 1.00 72.85  ? 472 ALA A O   1 
ATOM   2761 C CB  . ALA A 1 472 ? 122.637 138.162 171.290 1.00 72.85  ? 472 ALA A CB  1 
ATOM   2762 N N   . SER A 1 473 ? 121.520 139.139 168.514 1.00 73.78  ? 473 SER A N   1 
ATOM   2763 C CA  . SER A 1 473 ? 120.780 140.041 167.639 1.00 73.78  ? 473 SER A CA  1 
ATOM   2764 C C   . SER A 1 473 ? 119.766 139.280 166.794 1.00 73.78  ? 473 SER A C   1 
ATOM   2765 O O   . SER A 1 473 ? 118.687 139.807 166.500 1.00 73.78  ? 473 SER A O   1 
ATOM   2766 C CB  . SER A 1 473 ? 121.740 140.822 166.744 1.00 73.78  ? 473 SER A CB  1 
ATOM   2767 O OG  . SER A 1 473 ? 121.047 141.437 165.672 1.00 73.78  ? 473 SER A OG  1 
ATOM   2768 N N   . GLY A 1 474 ? 120.100 138.054 166.385 1.00 74.42  ? 474 GLY A N   1 
ATOM   2769 C CA  . GLY A 1 474 ? 119.113 137.213 165.728 1.00 74.42  ? 474 GLY A CA  1 
ATOM   2770 C C   . GLY A 1 474 ? 117.958 136.858 166.644 1.00 74.42  ? 474 GLY A C   1 
ATOM   2771 O O   . GLY A 1 474 ? 116.798 136.859 166.227 1.00 74.42  ? 474 GLY A O   1 
ATOM   2772 N N   . ALA A 1 475 ? 118.260 136.548 167.908 1.00 79.29  ? 475 ALA A N   1 
ATOM   2773 C CA  . ALA A 1 475 ? 117.202 136.307 168.882 1.00 79.29  ? 475 ALA A CA  1 
ATOM   2774 C C   . ALA A 1 475 ? 116.457 137.589 169.227 1.00 79.29  ? 475 ALA A C   1 
ATOM   2775 O O   . ALA A 1 475 ? 115.300 137.534 169.658 1.00 79.29  ? 475 ALA A O   1 
ATOM   2776 C CB  . ALA A 1 475 ? 117.778 135.673 170.147 1.00 79.29  ? 475 ALA A CB  1 
ATOM   2777 N N   . VAL A 1 476 ? 117.104 138.745 169.059 1.00 80.27  ? 476 VAL A N   1 
ATOM   2778 C CA  . VAL A 1 476 ? 116.419 140.016 169.272 1.00 80.27  ? 476 VAL A CA  1 
ATOM   2779 C C   . VAL A 1 476 ? 115.283 140.176 168.272 1.00 80.27  ? 476 VAL A C   1 
ATOM   2780 O O   . VAL A 1 476 ? 114.177 140.600 168.627 1.00 80.27  ? 476 VAL A O   1 
ATOM   2781 C CB  . VAL A 1 476 ? 117.418 141.184 169.187 1.00 80.27  ? 476 VAL A CB  1 
ATOM   2782 N N   . SER A 1 477 ? 115.536 139.836 167.006 1.00 81.29  ? 477 SER A N   1 
ATOM   2783 C CA  . SER A 1 477 ? 114.472 139.862 166.009 1.00 81.29  ? 477 SER A CA  1 
ATOM   2784 C C   . SER A 1 477 ? 113.423 138.793 166.285 1.00 81.29  ? 477 SER A C   1 
ATOM   2785 O O   . SER A 1 477 ? 112.249 138.979 165.947 1.00 81.29  ? 477 SER A O   1 
ATOM   2786 C CB  . SER A 1 477 ? 115.057 139.685 164.609 1.00 81.29  ? 477 SER A CB  1 
ATOM   2787 N N   . VAL A 1 478 ? 113.827 137.672 166.888 1.00 83.17  ? 478 VAL A N   1 
ATOM   2788 C CA  . VAL A 1 478 ? 112.873 136.618 167.227 1.00 83.17  ? 478 VAL A CA  1 
ATOM   2789 C C   . VAL A 1 478 ? 111.873 137.117 168.262 1.00 83.17  ? 478 VAL A C   1 
ATOM   2790 O O   . VAL A 1 478 ? 110.671 136.838 168.170 1.00 83.17  ? 478 VAL A O   1 
ATOM   2791 C CB  . VAL A 1 478 ? 113.615 135.361 167.717 1.00 83.17  ? 478 VAL A CB  1 
ATOM   2792 N N   . MET A 1 479 ? 112.353 137.853 169.268 1.00 84.20  ? 479 MET A N   1 
ATOM   2793 C CA  . MET A 1 479 ? 111.449 138.438 170.254 1.00 84.20  ? 479 MET A CA  1 
ATOM   2794 C C   . MET A 1 479 ? 110.498 139.431 169.600 1.00 84.20  ? 479 MET A C   1 
ATOM   2795 O O   . MET A 1 479 ? 109.310 139.479 169.937 1.00 84.20  ? 479 MET A O   1 
ATOM   2796 C CB  . MET A 1 479 ? 112.250 139.113 171.368 1.00 84.20  ? 479 MET A CB  1 
ATOM   2797 N N   . LYS A 1 480 ? 111.006 140.237 168.664 1.00 83.70  ? 480 LYS A N   1 
ATOM   2798 C CA  . LYS A 1 480 ? 110.130 141.102 167.883 1.00 83.70  ? 480 LYS A CA  1 
ATOM   2799 C C   . LYS A 1 480 ? 109.220 140.291 166.969 1.00 83.70  ? 480 LYS A C   1 
ATOM   2800 O O   . LYS A 1 480 ? 108.078 140.691 166.718 1.00 83.70  ? 480 LYS A O   1 
ATOM   2801 C CB  . LYS A 1 480 ? 110.958 142.093 167.066 1.00 83.70  ? 480 LYS A CB  1 
ATOM   2802 N N   . LYS A 1 481 ? 109.706 139.154 166.464 1.00 85.59  ? 481 LYS A N   1 
ATOM   2803 C CA  . LYS A 1 481 ? 108.876 138.287 165.637 1.00 85.59  ? 481 LYS A CA  1 
ATOM   2804 C C   . LYS A 1 481 ? 107.773 137.606 166.437 1.00 85.59  ? 481 LYS A C   1 
ATOM   2805 O O   . LYS A 1 481 ? 106.804 137.124 165.842 1.00 85.59  ? 481 LYS A O   1 
ATOM   2806 C CB  . LYS A 1 481 ? 109.740 137.233 164.944 1.00 85.59  ? 481 LYS A CB  1 
ATOM   2807 N N   . CYS A 1 482 ? 107.905 137.545 167.764 1.00 86.11  ? 482 CYS A N   1 
ATOM   2808 C CA  . CYS A 1 482 ? 106.858 136.947 168.587 1.00 86.11  ? 482 CYS A CA  1 
ATOM   2809 C C   . CYS A 1 482 ? 105.561 137.740 168.492 1.00 86.11  ? 482 CYS A C   1 
ATOM   2810 O O   . CYS A 1 482 ? 104.472 137.159 168.425 1.00 86.11  ? 482 CYS A O   1 
ATOM   2811 C CB  . CYS A 1 482 ? 107.323 136.849 170.040 1.00 86.11  ? 482 CYS A CB  1 
ATOM   2812 N N   . ARG A 1 483 ? 105.657 139.066 168.486 1.00 87.24  ? 483 ARG A N   1 
ATOM   2813 C CA  . ARG A 1 483 ? 104.482 139.921 168.379 1.00 87.24  ? 483 ARG A CA  1 
ATOM   2814 C C   . ARG A 1 483 ? 103.871 139.840 166.984 1.00 87.24  ? 483 ARG A C   1 
ATOM   2815 O O   . ARG A 1 483 ? 102.985 139.024 166.731 1.00 87.24  ? 483 ARG A O   1 
ATOM   2816 C CB  . ARG A 1 483 ? 104.841 141.369 168.712 1.00 87.24  ? 483 ARG A CB  1 
HETATM 2817 C CM2 . VIB B 2 .   ? 153.730 139.239 149.248 1.00 36.71  ? 501 VIB A CM2 1 
HETATM 2818 N N4A . VIB B 2 .   ? 151.338 140.422 153.308 1.00 36.71  ? 501 VIB A N4A 1 
HETATM 2819 C CM4 . VIB B 2 .   ? 149.252 135.272 152.732 1.00 36.71  ? 501 VIB A CM4 1 
HETATM 2820 O O1  . VIB B 2 .   ? 148.091 132.571 150.528 1.00 36.71  ? 501 VIB A O1  1 
HETATM 2821 C C7  . VIB B 2 .   ? 147.392 133.682 150.041 1.00 36.71  ? 501 VIB A C7  1 
HETATM 2822 C C6  . VIB B 2 .   ? 146.633 134.304 151.208 1.00 36.71  ? 501 VIB A C6  1 
HETATM 2823 C C2  . VIB B 2 .   ? 147.119 138.204 151.538 1.00 36.71  ? 501 VIB A C2  1 
HETATM 2824 S S1  . VIB B 2 .   ? 146.173 137.016 150.976 1.00 36.71  ? 501 VIB A S1  1 
HETATM 2825 C C5  . VIB B 2 .   ? 147.025 135.759 151.451 1.00 36.71  ? 501 VIB A C5  1 
HETATM 2826 C C4  . VIB B 2 .   ? 148.191 136.190 152.130 1.00 36.71  ? 501 VIB A C4  1 
HETATM 2827 N N3  . VIB B 2 .   ? 148.239 137.665 152.172 1.00 36.71  ? 501 VIB A N3  1 
HETATM 2828 C C7A . VIB B 2 .   ? 149.290 138.449 152.794 1.00 36.71  ? 501 VIB A C7A 1 
HETATM 2829 C C4A . VIB B 2 .   ? 151.440 139.606 152.110 1.00 36.71  ? 501 VIB A C4A 1 
HETATM 2830 N N3A . VIB B 2 .   ? 152.453 139.770 151.280 1.00 36.71  ? 501 VIB A N3A 1 
HETATM 2831 C C2A . VIB B 2 .   ? 152.549 139.032 150.193 1.00 36.71  ? 501 VIB A C2A 1 
HETATM 2832 N N1A . VIB B 2 .   ? 151.651 138.115 149.899 1.00 36.71  ? 501 VIB A N1A 1 
HETATM 2833 C C6A . VIB B 2 .   ? 150.615 137.904 150.687 1.00 36.71  ? 501 VIB A C6A 1 
HETATM 2834 C C5A . VIB B 2 .   ? 150.468 138.652 151.843 1.00 36.71  ? 501 VIB A C5A 1 
# 
