data_8Z6N
# 
_entry.id   8Z6N 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Z6N         pdb_00008z6n 10.2210/pdb8z6n/pdb 
WWPDB D_1300046737 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-23 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Z6N 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              zhi.lin@tju.edu.cn 
_pdbx_contact_author.name_first         Zhi 
_pdbx_contact_author.name_last          Lin 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8902-4935 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, Y.'  1 0000-0002-0207-149X 
'Lin, Z.'    2 0000-0002-8902-4935 
'Xiao, Y.J.' 3 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'The dimerization structure of CHASE4 domain of PA2072.' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zhang, Y.' 1 0000-0002-0207-149X 
primary 'Lin, Z.'   2 0000-0002-8902-4935 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Bifunctional diguanylate cyclase/phosphodiesterase' 23716.348 1   ? ? ? ? 
2 water   nat water                                                18.015    106 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GSIARHQDDIAIEQSHFYVEKALQNRRENSEQFSTTYSFWTDAYVYLGNRVDADWAFTKNNLGSVLYTTNGYDGVFVIDD
RGTRYAMLEGELSERSLADSLNADTGDILRSARRAAVDEAAISRYVDFDGAPAILVASAIKPTSDHAPIDLAKASVMVFV
DRLTPAKLAKLGGDYGIANLHLLAGGAAGDKESLALEGTPHRLAWVSSRPGSAMLRET
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSIARHQDDIAIEQSHFYVEKALQNRRENSEQFSTTYSFWTDAYVYLGNRVDADWAFTKNNLGSVLYTTNGYDGVFVIDD
RGTRYAMLEGELSERSLADSLNADTGDILRSARRAAVDEAAISRYVDFDGAPAILVASAIKPTSDHAPIDLAKASVMVFV
DRLTPAKLAKLGGDYGIANLHLLAGGAAGDKESLALEGTPHRLAWVSSRPGSAMLRET
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   ILE n 
1 4   ALA n 
1 5   ARG n 
1 6   HIS n 
1 7   GLN n 
1 8   ASP n 
1 9   ASP n 
1 10  ILE n 
1 11  ALA n 
1 12  ILE n 
1 13  GLU n 
1 14  GLN n 
1 15  SER n 
1 16  HIS n 
1 17  PHE n 
1 18  TYR n 
1 19  VAL n 
1 20  GLU n 
1 21  LYS n 
1 22  ALA n 
1 23  LEU n 
1 24  GLN n 
1 25  ASN n 
1 26  ARG n 
1 27  ARG n 
1 28  GLU n 
1 29  ASN n 
1 30  SER n 
1 31  GLU n 
1 32  GLN n 
1 33  PHE n 
1 34  SER n 
1 35  THR n 
1 36  THR n 
1 37  TYR n 
1 38  SER n 
1 39  PHE n 
1 40  TRP n 
1 41  THR n 
1 42  ASP n 
1 43  ALA n 
1 44  TYR n 
1 45  VAL n 
1 46  TYR n 
1 47  LEU n 
1 48  GLY n 
1 49  ASN n 
1 50  ARG n 
1 51  VAL n 
1 52  ASP n 
1 53  ALA n 
1 54  ASP n 
1 55  TRP n 
1 56  ALA n 
1 57  PHE n 
1 58  THR n 
1 59  LYS n 
1 60  ASN n 
1 61  ASN n 
1 62  LEU n 
1 63  GLY n 
1 64  SER n 
1 65  VAL n 
1 66  LEU n 
1 67  TYR n 
1 68  THR n 
1 69  THR n 
1 70  ASN n 
1 71  GLY n 
1 72  TYR n 
1 73  ASP n 
1 74  GLY n 
1 75  VAL n 
1 76  PHE n 
1 77  VAL n 
1 78  ILE n 
1 79  ASP n 
1 80  ASP n 
1 81  ARG n 
1 82  GLY n 
1 83  THR n 
1 84  ARG n 
1 85  TYR n 
1 86  ALA n 
1 87  MET n 
1 88  LEU n 
1 89  GLU n 
1 90  GLY n 
1 91  GLU n 
1 92  LEU n 
1 93  SER n 
1 94  GLU n 
1 95  ARG n 
1 96  SER n 
1 97  LEU n 
1 98  ALA n 
1 99  ASP n 
1 100 SER n 
1 101 LEU n 
1 102 ASN n 
1 103 ALA n 
1 104 ASP n 
1 105 THR n 
1 106 GLY n 
1 107 ASP n 
1 108 ILE n 
1 109 LEU n 
1 110 ARG n 
1 111 SER n 
1 112 ALA n 
1 113 ARG n 
1 114 ARG n 
1 115 ALA n 
1 116 ALA n 
1 117 VAL n 
1 118 ASP n 
1 119 GLU n 
1 120 ALA n 
1 121 ALA n 
1 122 ILE n 
1 123 SER n 
1 124 ARG n 
1 125 TYR n 
1 126 VAL n 
1 127 ASP n 
1 128 PHE n 
1 129 ASP n 
1 130 GLY n 
1 131 ALA n 
1 132 PRO n 
1 133 ALA n 
1 134 ILE n 
1 135 LEU n 
1 136 VAL n 
1 137 ALA n 
1 138 SER n 
1 139 ALA n 
1 140 ILE n 
1 141 LYS n 
1 142 PRO n 
1 143 THR n 
1 144 SER n 
1 145 ASP n 
1 146 HIS n 
1 147 ALA n 
1 148 PRO n 
1 149 ILE n 
1 150 ASP n 
1 151 LEU n 
1 152 ALA n 
1 153 LYS n 
1 154 ALA n 
1 155 SER n 
1 156 VAL n 
1 157 MET n 
1 158 VAL n 
1 159 PHE n 
1 160 VAL n 
1 161 ASP n 
1 162 ARG n 
1 163 LEU n 
1 164 THR n 
1 165 PRO n 
1 166 ALA n 
1 167 LYS n 
1 168 LEU n 
1 169 ALA n 
1 170 LYS n 
1 171 LEU n 
1 172 GLY n 
1 173 GLY n 
1 174 ASP n 
1 175 TYR n 
1 176 GLY n 
1 177 ILE n 
1 178 ALA n 
1 179 ASN n 
1 180 LEU n 
1 181 HIS n 
1 182 LEU n 
1 183 LEU n 
1 184 ALA n 
1 185 GLY n 
1 186 GLY n 
1 187 ALA n 
1 188 ALA n 
1 189 GLY n 
1 190 ASP n 
1 191 LYS n 
1 192 GLU n 
1 193 SER n 
1 194 LEU n 
1 195 ALA n 
1 196 LEU n 
1 197 GLU n 
1 198 GLY n 
1 199 THR n 
1 200 PRO n 
1 201 HIS n 
1 202 ARG n 
1 203 LEU n 
1 204 ALA n 
1 205 TRP n 
1 206 VAL n 
1 207 SER n 
1 208 SER n 
1 209 ARG n 
1 210 PRO n 
1 211 GLY n 
1 212 SER n 
1 213 ALA n 
1 214 MET n 
1 215 LEU n 
1 216 ARG n 
1 217 GLU n 
1 218 THR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   218 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PA2072 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    PAO1 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Pseudomonas aeruginosa PAO1' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     208964 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'BL21(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   38  ?   ?   ?   A . n 
A 1 2   SER 2   39  39  SER SER A . n 
A 1 3   ILE 3   40  40  ILE ILE A . n 
A 1 4   ALA 4   41  41  ALA ALA A . n 
A 1 5   ARG 5   42  42  ARG ARG A . n 
A 1 6   HIS 6   43  43  HIS HIS A . n 
A 1 7   GLN 7   44  44  GLN GLN A . n 
A 1 8   ASP 8   45  45  ASP ASP A . n 
A 1 9   ASP 9   46  46  ASP ASP A . n 
A 1 10  ILE 10  47  47  ILE ILE A . n 
A 1 11  ALA 11  48  48  ALA ALA A . n 
A 1 12  ILE 12  49  49  ILE ILE A . n 
A 1 13  GLU 13  50  50  GLU GLU A . n 
A 1 14  GLN 14  51  51  GLN GLN A . n 
A 1 15  SER 15  52  52  SER SER A . n 
A 1 16  HIS 16  53  53  HIS HIS A . n 
A 1 17  PHE 17  54  54  PHE PHE A . n 
A 1 18  TYR 18  55  55  TYR TYR A . n 
A 1 19  VAL 19  56  56  VAL VAL A . n 
A 1 20  GLU 20  57  57  GLU GLU A . n 
A 1 21  LYS 21  58  58  LYS LYS A . n 
A 1 22  ALA 22  59  59  ALA ALA A . n 
A 1 23  LEU 23  60  60  LEU LEU A . n 
A 1 24  GLN 24  61  61  GLN GLN A . n 
A 1 25  ASN 25  62  62  ASN ASN A . n 
A 1 26  ARG 26  63  63  ARG ARG A . n 
A 1 27  ARG 27  64  64  ARG ARG A . n 
A 1 28  GLU 28  65  65  GLU GLU A . n 
A 1 29  ASN 29  66  66  ASN ASN A . n 
A 1 30  SER 30  67  67  SER SER A . n 
A 1 31  GLU 31  68  68  GLU GLU A . n 
A 1 32  GLN 32  69  69  GLN GLN A . n 
A 1 33  PHE 33  70  70  PHE PHE A . n 
A 1 34  SER 34  71  71  SER SER A . n 
A 1 35  THR 35  72  72  THR THR A . n 
A 1 36  THR 36  73  73  THR THR A . n 
A 1 37  TYR 37  74  74  TYR TYR A . n 
A 1 38  SER 38  75  75  SER SER A . n 
A 1 39  PHE 39  76  76  PHE PHE A . n 
A 1 40  TRP 40  77  77  TRP TRP A . n 
A 1 41  THR 41  78  78  THR THR A . n 
A 1 42  ASP 42  79  79  ASP ASP A . n 
A 1 43  ALA 43  80  80  ALA ALA A . n 
A 1 44  TYR 44  81  81  TYR TYR A . n 
A 1 45  VAL 45  82  82  VAL VAL A . n 
A 1 46  TYR 46  83  83  TYR TYR A . n 
A 1 47  LEU 47  84  84  LEU LEU A . n 
A 1 48  GLY 48  85  85  GLY GLY A . n 
A 1 49  ASN 49  86  86  ASN ASN A . n 
A 1 50  ARG 50  87  87  ARG ARG A . n 
A 1 51  VAL 51  88  88  VAL VAL A . n 
A 1 52  ASP 52  89  89  ASP ASP A . n 
A 1 53  ALA 53  90  90  ALA ALA A . n 
A 1 54  ASP 54  91  91  ASP ASP A . n 
A 1 55  TRP 55  92  92  TRP TRP A . n 
A 1 56  ALA 56  93  93  ALA ALA A . n 
A 1 57  PHE 57  94  94  PHE PHE A . n 
A 1 58  THR 58  95  95  THR THR A . n 
A 1 59  LYS 59  96  96  LYS LYS A . n 
A 1 60  ASN 60  97  97  ASN ASN A . n 
A 1 61  ASN 61  98  98  ASN ASN A . n 
A 1 62  LEU 62  99  99  LEU LEU A . n 
A 1 63  GLY 63  100 100 GLY GLY A . n 
A 1 64  SER 64  101 101 SER SER A . n 
A 1 65  VAL 65  102 102 VAL VAL A . n 
A 1 66  LEU 66  103 103 LEU LEU A . n 
A 1 67  TYR 67  104 104 TYR TYR A . n 
A 1 68  THR 68  105 105 THR THR A . n 
A 1 69  THR 69  106 106 THR THR A . n 
A 1 70  ASN 70  107 107 ASN ASN A . n 
A 1 71  GLY 71  108 108 GLY GLY A . n 
A 1 72  TYR 72  109 109 TYR TYR A . n 
A 1 73  ASP 73  110 110 ASP ASP A . n 
A 1 74  GLY 74  111 111 GLY GLY A . n 
A 1 75  VAL 75  112 112 VAL VAL A . n 
A 1 76  PHE 76  113 113 PHE PHE A . n 
A 1 77  VAL 77  114 114 VAL VAL A . n 
A 1 78  ILE 78  115 115 ILE ILE A . n 
A 1 79  ASP 79  116 116 ASP ASP A . n 
A 1 80  ASP 80  117 117 ASP ASP A . n 
A 1 81  ARG 81  118 118 ARG ARG A . n 
A 1 82  GLY 82  119 119 GLY GLY A . n 
A 1 83  THR 83  120 120 THR THR A . n 
A 1 84  ARG 84  121 121 ARG ARG A . n 
A 1 85  TYR 85  122 122 TYR TYR A . n 
A 1 86  ALA 86  123 123 ALA ALA A . n 
A 1 87  MET 87  124 124 MET MET A . n 
A 1 88  LEU 88  125 125 LEU LEU A . n 
A 1 89  GLU 89  126 126 GLU GLU A . n 
A 1 90  GLY 90  127 127 GLY GLY A . n 
A 1 91  GLU 91  128 128 GLU GLU A . n 
A 1 92  LEU 92  129 129 LEU LEU A . n 
A 1 93  SER 93  130 130 SER SER A . n 
A 1 94  GLU 94  131 131 GLU GLU A . n 
A 1 95  ARG 95  132 132 ARG ARG A . n 
A 1 96  SER 96  133 133 SER SER A . n 
A 1 97  LEU 97  134 134 LEU LEU A . n 
A 1 98  ALA 98  135 135 ALA ALA A . n 
A 1 99  ASP 99  136 136 ASP ASP A . n 
A 1 100 SER 100 137 137 SER SER A . n 
A 1 101 LEU 101 138 138 LEU LEU A . n 
A 1 102 ASN 102 139 139 ASN ASN A . n 
A 1 103 ALA 103 140 140 ALA ALA A . n 
A 1 104 ASP 104 141 141 ASP ASP A . n 
A 1 105 THR 105 142 142 THR THR A . n 
A 1 106 GLY 106 143 143 GLY GLY A . n 
A 1 107 ASP 107 144 144 ASP ASP A . n 
A 1 108 ILE 108 145 145 ILE ILE A . n 
A 1 109 LEU 109 146 146 LEU LEU A . n 
A 1 110 ARG 110 147 147 ARG ARG A . n 
A 1 111 SER 111 148 148 SER SER A . n 
A 1 112 ALA 112 149 149 ALA ALA A . n 
A 1 113 ARG 113 150 150 ARG ARG A . n 
A 1 114 ARG 114 151 151 ARG ARG A . n 
A 1 115 ALA 115 152 152 ALA ALA A . n 
A 1 116 ALA 116 153 153 ALA ALA A . n 
A 1 117 VAL 117 154 154 VAL VAL A . n 
A 1 118 ASP 118 155 155 ASP ASP A . n 
A 1 119 GLU 119 156 156 GLU GLU A . n 
A 1 120 ALA 120 157 157 ALA ALA A . n 
A 1 121 ALA 121 158 158 ALA ALA A . n 
A 1 122 ILE 122 159 159 ILE ILE A . n 
A 1 123 SER 123 160 160 SER SER A . n 
A 1 124 ARG 124 161 161 ARG ARG A . n 
A 1 125 TYR 125 162 162 TYR TYR A . n 
A 1 126 VAL 126 163 163 VAL VAL A . n 
A 1 127 ASP 127 164 164 ASP ASP A . n 
A 1 128 PHE 128 165 165 PHE PHE A . n 
A 1 129 ASP 129 166 166 ASP ASP A . n 
A 1 130 GLY 130 167 167 GLY GLY A . n 
A 1 131 ALA 131 168 168 ALA ALA A . n 
A 1 132 PRO 132 169 169 PRO PRO A . n 
A 1 133 ALA 133 170 170 ALA ALA A . n 
A 1 134 ILE 134 171 171 ILE ILE A . n 
A 1 135 LEU 135 172 172 LEU LEU A . n 
A 1 136 VAL 136 173 173 VAL VAL A . n 
A 1 137 ALA 137 174 174 ALA ALA A . n 
A 1 138 SER 138 175 175 SER SER A . n 
A 1 139 ALA 139 176 176 ALA ALA A . n 
A 1 140 ILE 140 177 177 ILE ILE A . n 
A 1 141 LYS 141 178 178 LYS LYS A . n 
A 1 142 PRO 142 179 179 PRO PRO A . n 
A 1 143 THR 143 180 180 THR THR A . n 
A 1 144 SER 144 181 181 SER SER A . n 
A 1 145 ASP 145 182 182 ASP ASP A . n 
A 1 146 HIS 146 183 183 HIS HIS A . n 
A 1 147 ALA 147 184 184 ALA ALA A . n 
A 1 148 PRO 148 185 185 PRO PRO A . n 
A 1 149 ILE 149 186 186 ILE ILE A . n 
A 1 150 ASP 150 187 187 ASP ASP A . n 
A 1 151 LEU 151 188 188 LEU LEU A . n 
A 1 152 ALA 152 189 189 ALA ALA A . n 
A 1 153 LYS 153 190 190 LYS LYS A . n 
A 1 154 ALA 154 191 191 ALA ALA A . n 
A 1 155 SER 155 192 192 SER SER A . n 
A 1 156 VAL 156 193 193 VAL VAL A . n 
A 1 157 MET 157 194 194 MET MET A . n 
A 1 158 VAL 158 195 195 VAL VAL A . n 
A 1 159 PHE 159 196 196 PHE PHE A . n 
A 1 160 VAL 160 197 197 VAL VAL A . n 
A 1 161 ASP 161 198 198 ASP ASP A . n 
A 1 162 ARG 162 199 199 ARG ARG A . n 
A 1 163 LEU 163 200 200 LEU LEU A . n 
A 1 164 THR 164 201 201 THR THR A . n 
A 1 165 PRO 165 202 202 PRO PRO A . n 
A 1 166 ALA 166 203 203 ALA ALA A . n 
A 1 167 LYS 167 204 204 LYS LYS A . n 
A 1 168 LEU 168 205 205 LEU LEU A . n 
A 1 169 ALA 169 206 206 ALA ALA A . n 
A 1 170 LYS 170 207 207 LYS LYS A . n 
A 1 171 LEU 171 208 208 LEU LEU A . n 
A 1 172 GLY 172 209 209 GLY GLY A . n 
A 1 173 GLY 173 210 210 GLY GLY A . n 
A 1 174 ASP 174 211 211 ASP ASP A . n 
A 1 175 TYR 175 212 212 TYR TYR A . n 
A 1 176 GLY 176 213 213 GLY GLY A . n 
A 1 177 ILE 177 214 214 ILE ILE A . n 
A 1 178 ALA 178 215 215 ALA ALA A . n 
A 1 179 ASN 179 216 216 ASN ASN A . n 
A 1 180 LEU 180 217 217 LEU LEU A . n 
A 1 181 HIS 181 218 218 HIS HIS A . n 
A 1 182 LEU 182 219 219 LEU LEU A . n 
A 1 183 LEU 183 220 220 LEU LEU A . n 
A 1 184 ALA 184 221 221 ALA ALA A . n 
A 1 185 GLY 185 222 ?   ?   ?   A . n 
A 1 186 GLY 186 223 ?   ?   ?   A . n 
A 1 187 ALA 187 224 ?   ?   ?   A . n 
A 1 188 ALA 188 225 ?   ?   ?   A . n 
A 1 189 GLY 189 226 ?   ?   ?   A . n 
A 1 190 ASP 190 227 227 ASP ASP A . n 
A 1 191 LYS 191 228 228 LYS LYS A . n 
A 1 192 GLU 192 229 229 GLU GLU A . n 
A 1 193 SER 193 230 230 SER SER A . n 
A 1 194 LEU 194 231 231 LEU LEU A . n 
A 1 195 ALA 195 232 232 ALA ALA A . n 
A 1 196 LEU 196 233 233 LEU LEU A . n 
A 1 197 GLU 197 234 234 GLU GLU A . n 
A 1 198 GLY 198 235 235 GLY GLY A . n 
A 1 199 THR 199 236 236 THR THR A . n 
A 1 200 PRO 200 237 237 PRO PRO A . n 
A 1 201 HIS 201 238 238 HIS HIS A . n 
A 1 202 ARG 202 239 239 ARG ARG A . n 
A 1 203 LEU 203 240 240 LEU LEU A . n 
A 1 204 ALA 204 241 241 ALA ALA A . n 
A 1 205 TRP 205 242 242 TRP TRP A . n 
A 1 206 VAL 206 243 243 VAL VAL A . n 
A 1 207 SER 207 244 244 SER SER A . n 
A 1 208 SER 208 245 ?   ?   ?   A . n 
A 1 209 ARG 209 246 ?   ?   ?   A . n 
A 1 210 PRO 210 247 ?   ?   ?   A . n 
A 1 211 GLY 211 248 ?   ?   ?   A . n 
A 1 212 SER 212 249 ?   ?   ?   A . n 
A 1 213 ALA 213 250 ?   ?   ?   A . n 
A 1 214 MET 214 251 ?   ?   ?   A . n 
A 1 215 LEU 215 252 ?   ?   ?   A . n 
A 1 216 ARG 216 253 ?   ?   ?   A . n 
A 1 217 GLU 217 254 ?   ?   ?   A . n 
A 1 218 THR 218 255 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   301 100 HOH HOH A . 
B 2 HOH 2   302 86  HOH HOH A . 
B 2 HOH 3   303 17  HOH HOH A . 
B 2 HOH 4   304 26  HOH HOH A . 
B 2 HOH 5   305 87  HOH HOH A . 
B 2 HOH 6   306 95  HOH HOH A . 
B 2 HOH 7   307 12  HOH HOH A . 
B 2 HOH 8   308 22  HOH HOH A . 
B 2 HOH 9   309 93  HOH HOH A . 
B 2 HOH 10  310 36  HOH HOH A . 
B 2 HOH 11  311 1   HOH HOH A . 
B 2 HOH 12  312 60  HOH HOH A . 
B 2 HOH 13  313 4   HOH HOH A . 
B 2 HOH 14  314 10  HOH HOH A . 
B 2 HOH 15  315 15  HOH HOH A . 
B 2 HOH 16  316 11  HOH HOH A . 
B 2 HOH 17  317 58  HOH HOH A . 
B 2 HOH 18  318 49  HOH HOH A . 
B 2 HOH 19  319 97  HOH HOH A . 
B 2 HOH 20  320 69  HOH HOH A . 
B 2 HOH 21  321 71  HOH HOH A . 
B 2 HOH 22  322 8   HOH HOH A . 
B 2 HOH 23  323 18  HOH HOH A . 
B 2 HOH 24  324 46  HOH HOH A . 
B 2 HOH 25  325 27  HOH HOH A . 
B 2 HOH 26  326 28  HOH HOH A . 
B 2 HOH 27  327 43  HOH HOH A . 
B 2 HOH 28  328 16  HOH HOH A . 
B 2 HOH 29  329 20  HOH HOH A . 
B 2 HOH 30  330 3   HOH HOH A . 
B 2 HOH 31  331 47  HOH HOH A . 
B 2 HOH 32  332 24  HOH HOH A . 
B 2 HOH 33  333 61  HOH HOH A . 
B 2 HOH 34  334 75  HOH HOH A . 
B 2 HOH 35  335 59  HOH HOH A . 
B 2 HOH 36  336 14  HOH HOH A . 
B 2 HOH 37  337 6   HOH HOH A . 
B 2 HOH 38  338 23  HOH HOH A . 
B 2 HOH 39  339 110 HOH HOH A . 
B 2 HOH 40  340 65  HOH HOH A . 
B 2 HOH 41  341 96  HOH HOH A . 
B 2 HOH 42  342 35  HOH HOH A . 
B 2 HOH 43  343 52  HOH HOH A . 
B 2 HOH 44  344 42  HOH HOH A . 
B 2 HOH 45  345 33  HOH HOH A . 
B 2 HOH 46  346 53  HOH HOH A . 
B 2 HOH 47  347 63  HOH HOH A . 
B 2 HOH 48  348 40  HOH HOH A . 
B 2 HOH 49  349 2   HOH HOH A . 
B 2 HOH 50  350 92  HOH HOH A . 
B 2 HOH 51  351 102 HOH HOH A . 
B 2 HOH 52  352 56  HOH HOH A . 
B 2 HOH 53  353 44  HOH HOH A . 
B 2 HOH 54  354 88  HOH HOH A . 
B 2 HOH 55  355 7   HOH HOH A . 
B 2 HOH 56  356 72  HOH HOH A . 
B 2 HOH 57  357 67  HOH HOH A . 
B 2 HOH 58  358 45  HOH HOH A . 
B 2 HOH 59  359 29  HOH HOH A . 
B 2 HOH 60  360 31  HOH HOH A . 
B 2 HOH 61  361 76  HOH HOH A . 
B 2 HOH 62  362 74  HOH HOH A . 
B 2 HOH 63  363 30  HOH HOH A . 
B 2 HOH 64  364 80  HOH HOH A . 
B 2 HOH 65  365 77  HOH HOH A . 
B 2 HOH 66  366 50  HOH HOH A . 
B 2 HOH 67  367 89  HOH HOH A . 
B 2 HOH 68  368 9   HOH HOH A . 
B 2 HOH 69  369 64  HOH HOH A . 
B 2 HOH 70  370 107 HOH HOH A . 
B 2 HOH 71  371 5   HOH HOH A . 
B 2 HOH 72  372 13  HOH HOH A . 
B 2 HOH 73  373 48  HOH HOH A . 
B 2 HOH 74  374 32  HOH HOH A . 
B 2 HOH 75  375 106 HOH HOH A . 
B 2 HOH 76  376 101 HOH HOH A . 
B 2 HOH 77  377 25  HOH HOH A . 
B 2 HOH 78  378 82  HOH HOH A . 
B 2 HOH 79  379 99  HOH HOH A . 
B 2 HOH 80  380 105 HOH HOH A . 
B 2 HOH 81  381 79  HOH HOH A . 
B 2 HOH 82  382 73  HOH HOH A . 
B 2 HOH 83  383 91  HOH HOH A . 
B 2 HOH 84  384 37  HOH HOH A . 
B 2 HOH 85  385 109 HOH HOH A . 
B 2 HOH 86  386 55  HOH HOH A . 
B 2 HOH 87  387 104 HOH HOH A . 
B 2 HOH 88  388 38  HOH HOH A . 
B 2 HOH 89  389 70  HOH HOH A . 
B 2 HOH 90  390 78  HOH HOH A . 
B 2 HOH 91  391 90  HOH HOH A . 
B 2 HOH 92  392 108 HOH HOH A . 
B 2 HOH 93  393 103 HOH HOH A . 
B 2 HOH 94  394 62  HOH HOH A . 
B 2 HOH 95  395 83  HOH HOH A . 
B 2 HOH 96  396 39  HOH HOH A . 
B 2 HOH 97  397 85  HOH HOH A . 
B 2 HOH 98  398 34  HOH HOH A . 
B 2 HOH 99  399 98  HOH HOH A . 
B 2 HOH 100 400 94  HOH HOH A . 
B 2 HOH 101 401 51  HOH HOH A . 
B 2 HOH 102 402 68  HOH HOH A . 
B 2 HOH 103 403 57  HOH HOH A . 
B 2 HOH 104 404 41  HOH HOH A . 
B 2 HOH 105 405 84  HOH HOH A . 
B 2 HOH 106 406 81  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.18.2_3874 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           2 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           3 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-3000 ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Z6N 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     64.552 
_cell.length_a_esd                 ? 
_cell.length_b                     75.945 
_cell.length_b_esd                 ? 
_cell.length_c                     103.658 
_cell.length_c_esd                 ? 
_cell.volume                       508173.149 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Z6N 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                24 
_symmetry.space_group_name_Hall            'I 2b 2c' 
_symmetry.space_group_name_H-M             'I 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Z6N 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.76 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.49 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Sodium citrate tribasic dihydrate, 20% w/v Polyethylene glycol 3,350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-10-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9793 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL18U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9793 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL18U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          25.52 
_reflns.entry_id                                       8Z6N 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.385 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     10273 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.4 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          22.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.067 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.39 
_reflns_shell.d_res_low                                     2.44 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             459 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.965 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               25.39 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8Z6N 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.39 
_refine.ls_d_res_low                             24.59 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     10265 
_refine.ls_number_reflns_R_free                  490 
_refine.ls_number_reflns_R_work                  9775 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.15 
_refine.ls_percent_reflns_R_free                 4.77 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1846 
_refine.ls_R_factor_R_free                       0.2197 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1827 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.0095 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2530 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.39 
_refine_hist.d_res_low                        24.59 
_refine_hist.number_atoms_solvent             106 
_refine_hist.number_atoms_total               1669 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1563 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0019  ? 1593 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.4765  ? 2163 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0397  ? 243  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0026  ? 282  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 19.4542 ? 566  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.39 2.73  . . 159 3128 96.59 . . . . 0.1848 . . . . . . . . . . . 0.2297 
'X-RAY DIFFRACTION' 2.73 3.44  . . 160 3280 99.05 . . . . 0.1732 . . . . . . . . . . . 0.2119 
'X-RAY DIFFRACTION' 3.44 24.59 . . 171 3367 98.74 . . . . 0.1875 . . . . . . . . . . . 0.2208 
# 
_struct.entry_id                     8Z6N 
_struct.title                        'The dimerization structure of CHASE4 domain of PA2072 (alpha form)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Z6N 
_struct_keywords.text            'SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q9I243_PSEAE 
_struct_ref.pdbx_db_accession          Q9I243 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;IARHQDDIAIEQSHFYVEKALQNRRENSEQFSTTYSFWTDAYVYLGNRVDADWAFTKNNLGSVLYTTNGYDGVFVIDDRG
TRYAMLEGELSERSLADSLNADTGDILRSARRAAVDEAAISRYVDFDGAPAILVASAIKPTSDHAPIDLAKASVMVFVDR
LTPAKLAKLGGDYGIANLHLLAGGAAGDKESLALEGTPHRLAWVSSRPGSAMLRET
;
_struct_ref.pdbx_align_begin           40 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8Z6N 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 218 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q9I243 
_struct_ref_seq.db_align_beg                  40 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  255 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       40 
_struct_ref_seq.pdbx_auth_seq_align_end       255 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8Z6N GLY A 1 ? UNP Q9I243 ? ? 'expression tag' 38 1 
1 8Z6N SER A 2 ? UNP Q9I243 ? ? 'expression tag' 39 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B 
1 2 A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 8_555 x,-y,-z+1/2 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 51.8290000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 HIS A 6   ? PHE A 39  ? HIS A 43  PHE A 76  1 ? 34 
HELX_P HELX_P2 AA2 TRP A 40  ? GLY A 48  ? TRP A 77  GLY A 85  1 ? 9  
HELX_P HELX_P3 AA3 ASP A 52  ? PHE A 57  ? ASP A 89  PHE A 94  1 ? 6  
HELX_P HELX_P4 AA4 SER A 64  ? THR A 69  ? SER A 101 THR A 106 1 ? 6  
HELX_P HELX_P5 AA5 ASP A 104 ? ASP A 118 ? ASP A 141 ASP A 155 1 ? 15 
HELX_P HELX_P6 AA6 ASP A 150 ? ALA A 154 ? ASP A 187 ALA A 191 5 ? 5  
HELX_P HELX_P7 AA7 THR A 164 ? TYR A 175 ? THR A 201 TYR A 212 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 91  ? LEU A 92  ? GLU A 128 LEU A 129 
AA1 2 GLY A 82  ? LEU A 88  ? GLY A 119 LEU A 125 
AA1 3 GLY A 74  ? ASP A 79  ? GLY A 111 ASP A 116 
AA1 4 VAL A 156 ? ARG A 162 ? VAL A 193 ARG A 199 
AA1 5 ALA A 131 ? ALA A 139 ? ALA A 168 ALA A 176 
AA1 6 ILE A 122 ? PHE A 128 ? ILE A 159 PHE A 165 
AA2 1 ALA A 178 ? LEU A 182 ? ALA A 215 LEU A 219 
AA2 2 ARG A 202 ? VAL A 206 ? ARG A 239 VAL A 243 
AA2 3 GLU A 192 ? ALA A 195 ? GLU A 229 ALA A 232 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLU A 91  ? O GLU A 128 N LEU A 88  ? N LEU A 125 
AA1 2 3 O ARG A 84  ? O ARG A 121 N VAL A 77  ? N VAL A 114 
AA1 3 4 N GLY A 74  ? N GLY A 111 O VAL A 160 ? O VAL A 197 
AA1 4 5 O ASP A 161 ? O ASP A 198 N ILE A 134 ? N ILE A 171 
AA1 5 6 O ALA A 131 ? O ALA A 168 N PHE A 128 ? N PHE A 165 
AA2 1 2 N HIS A 181 ? N HIS A 218 O ALA A 204 ? O ALA A 241 
AA2 2 3 O TRP A 205 ? O TRP A 242 N GLU A 192 ? N GLU A 229 
# 
_pdbx_entry_details.entry_id                   8Z6N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    ASN 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     86 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             -119.73 
_pdbx_validate_torsion.psi             -103.51 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z             
2 x,-y,-z+1/2       
3 -x+1/2,y,-z       
4 -x,-y+1/2,z       
5 x+1/2,y+1/2,z+1/2 
6 x+1/2,-y+1/2,-z+1 
7 -x+1,y+1/2,-z+1/2 
8 -x+1/2,-y+1,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 38  ? A GLY 1   
2  1 Y 1 A GLY 222 ? A GLY 185 
3  1 Y 1 A GLY 223 ? A GLY 186 
4  1 Y 1 A ALA 224 ? A ALA 187 
5  1 Y 1 A ALA 225 ? A ALA 188 
6  1 Y 1 A GLY 226 ? A GLY 189 
7  1 Y 1 A SER 245 ? A SER 208 
8  1 Y 1 A ARG 246 ? A ARG 209 
9  1 Y 1 A PRO 247 ? A PRO 210 
10 1 Y 1 A GLY 248 ? A GLY 211 
11 1 Y 1 A SER 249 ? A SER 212 
12 1 Y 1 A ALA 250 ? A ALA 213 
13 1 Y 1 A MET 251 ? A MET 214 
14 1 Y 1 A LEU 252 ? A LEU 215 
15 1 Y 1 A ARG 253 ? A ARG 216 
16 1 Y 1 A GLU 254 ? A GLU 217 
17 1 Y 1 A THR 255 ? A THR 218 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
GLN N    N N N 74  
GLN CA   C N S 75  
GLN C    C N N 76  
GLN O    O N N 77  
GLN CB   C N N 78  
GLN CG   C N N 79  
GLN CD   C N N 80  
GLN OE1  O N N 81  
GLN NE2  N N N 82  
GLN OXT  O N N 83  
GLN H    H N N 84  
GLN H2   H N N 85  
GLN HA   H N N 86  
GLN HB2  H N N 87  
GLN HB3  H N N 88  
GLN HG2  H N N 89  
GLN HG3  H N N 90  
GLN HE21 H N N 91  
GLN HE22 H N N 92  
GLN HXT  H N N 93  
GLU N    N N N 94  
GLU CA   C N S 95  
GLU C    C N N 96  
GLU O    O N N 97  
GLU CB   C N N 98  
GLU CG   C N N 99  
GLU CD   C N N 100 
GLU OE1  O N N 101 
GLU OE2  O N N 102 
GLU OXT  O N N 103 
GLU H    H N N 104 
GLU H2   H N N 105 
GLU HA   H N N 106 
GLU HB2  H N N 107 
GLU HB3  H N N 108 
GLU HG2  H N N 109 
GLU HG3  H N N 110 
GLU HE2  H N N 111 
GLU HXT  H N N 112 
GLY N    N N N 113 
GLY CA   C N N 114 
GLY C    C N N 115 
GLY O    O N N 116 
GLY OXT  O N N 117 
GLY H    H N N 118 
GLY H2   H N N 119 
GLY HA2  H N N 120 
GLY HA3  H N N 121 
GLY HXT  H N N 122 
HIS N    N N N 123 
HIS CA   C N S 124 
HIS C    C N N 125 
HIS O    O N N 126 
HIS CB   C N N 127 
HIS CG   C Y N 128 
HIS ND1  N Y N 129 
HIS CD2  C Y N 130 
HIS CE1  C Y N 131 
HIS NE2  N Y N 132 
HIS OXT  O N N 133 
HIS H    H N N 134 
HIS H2   H N N 135 
HIS HA   H N N 136 
HIS HB2  H N N 137 
HIS HB3  H N N 138 
HIS HD1  H N N 139 
HIS HD2  H N N 140 
HIS HE1  H N N 141 
HIS HE2  H N N 142 
HIS HXT  H N N 143 
HOH O    O N N 144 
HOH H1   H N N 145 
HOH H2   H N N 146 
ILE N    N N N 147 
ILE CA   C N S 148 
ILE C    C N N 149 
ILE O    O N N 150 
ILE CB   C N S 151 
ILE CG1  C N N 152 
ILE CG2  C N N 153 
ILE CD1  C N N 154 
ILE OXT  O N N 155 
ILE H    H N N 156 
ILE H2   H N N 157 
ILE HA   H N N 158 
ILE HB   H N N 159 
ILE HG12 H N N 160 
ILE HG13 H N N 161 
ILE HG21 H N N 162 
ILE HG22 H N N 163 
ILE HG23 H N N 164 
ILE HD11 H N N 165 
ILE HD12 H N N 166 
ILE HD13 H N N 167 
ILE HXT  H N N 168 
LEU N    N N N 169 
LEU CA   C N S 170 
LEU C    C N N 171 
LEU O    O N N 172 
LEU CB   C N N 173 
LEU CG   C N N 174 
LEU CD1  C N N 175 
LEU CD2  C N N 176 
LEU OXT  O N N 177 
LEU H    H N N 178 
LEU H2   H N N 179 
LEU HA   H N N 180 
LEU HB2  H N N 181 
LEU HB3  H N N 182 
LEU HG   H N N 183 
LEU HD11 H N N 184 
LEU HD12 H N N 185 
LEU HD13 H N N 186 
LEU HD21 H N N 187 
LEU HD22 H N N 188 
LEU HD23 H N N 189 
LEU HXT  H N N 190 
LYS N    N N N 191 
LYS CA   C N S 192 
LYS C    C N N 193 
LYS O    O N N 194 
LYS CB   C N N 195 
LYS CG   C N N 196 
LYS CD   C N N 197 
LYS CE   C N N 198 
LYS NZ   N N N 199 
LYS OXT  O N N 200 
LYS H    H N N 201 
LYS H2   H N N 202 
LYS HA   H N N 203 
LYS HB2  H N N 204 
LYS HB3  H N N 205 
LYS HG2  H N N 206 
LYS HG3  H N N 207 
LYS HD2  H N N 208 
LYS HD3  H N N 209 
LYS HE2  H N N 210 
LYS HE3  H N N 211 
LYS HZ1  H N N 212 
LYS HZ2  H N N 213 
LYS HZ3  H N N 214 
LYS HXT  H N N 215 
MET N    N N N 216 
MET CA   C N S 217 
MET C    C N N 218 
MET O    O N N 219 
MET CB   C N N 220 
MET CG   C N N 221 
MET SD   S N N 222 
MET CE   C N N 223 
MET OXT  O N N 224 
MET H    H N N 225 
MET H2   H N N 226 
MET HA   H N N 227 
MET HB2  H N N 228 
MET HB3  H N N 229 
MET HG2  H N N 230 
MET HG3  H N N 231 
MET HE1  H N N 232 
MET HE2  H N N 233 
MET HE3  H N N 234 
MET HXT  H N N 235 
PHE N    N N N 236 
PHE CA   C N S 237 
PHE C    C N N 238 
PHE O    O N N 239 
PHE CB   C N N 240 
PHE CG   C Y N 241 
PHE CD1  C Y N 242 
PHE CD2  C Y N 243 
PHE CE1  C Y N 244 
PHE CE2  C Y N 245 
PHE CZ   C Y N 246 
PHE OXT  O N N 247 
PHE H    H N N 248 
PHE H2   H N N 249 
PHE HA   H N N 250 
PHE HB2  H N N 251 
PHE HB3  H N N 252 
PHE HD1  H N N 253 
PHE HD2  H N N 254 
PHE HE1  H N N 255 
PHE HE2  H N N 256 
PHE HZ   H N N 257 
PHE HXT  H N N 258 
PRO N    N N N 259 
PRO CA   C N S 260 
PRO C    C N N 261 
PRO O    O N N 262 
PRO CB   C N N 263 
PRO CG   C N N 264 
PRO CD   C N N 265 
PRO OXT  O N N 266 
PRO H    H N N 267 
PRO HA   H N N 268 
PRO HB2  H N N 269 
PRO HB3  H N N 270 
PRO HG2  H N N 271 
PRO HG3  H N N 272 
PRO HD2  H N N 273 
PRO HD3  H N N 274 
PRO HXT  H N N 275 
SER N    N N N 276 
SER CA   C N S 277 
SER C    C N N 278 
SER O    O N N 279 
SER CB   C N N 280 
SER OG   O N N 281 
SER OXT  O N N 282 
SER H    H N N 283 
SER H2   H N N 284 
SER HA   H N N 285 
SER HB2  H N N 286 
SER HB3  H N N 287 
SER HG   H N N 288 
SER HXT  H N N 289 
THR N    N N N 290 
THR CA   C N S 291 
THR C    C N N 292 
THR O    O N N 293 
THR CB   C N R 294 
THR OG1  O N N 295 
THR CG2  C N N 296 
THR OXT  O N N 297 
THR H    H N N 298 
THR H2   H N N 299 
THR HA   H N N 300 
THR HB   H N N 301 
THR HG1  H N N 302 
THR HG21 H N N 303 
THR HG22 H N N 304 
THR HG23 H N N 305 
THR HXT  H N N 306 
TRP N    N N N 307 
TRP CA   C N S 308 
TRP C    C N N 309 
TRP O    O N N 310 
TRP CB   C N N 311 
TRP CG   C Y N 312 
TRP CD1  C Y N 313 
TRP CD2  C Y N 314 
TRP NE1  N Y N 315 
TRP CE2  C Y N 316 
TRP CE3  C Y N 317 
TRP CZ2  C Y N 318 
TRP CZ3  C Y N 319 
TRP CH2  C Y N 320 
TRP OXT  O N N 321 
TRP H    H N N 322 
TRP H2   H N N 323 
TRP HA   H N N 324 
TRP HB2  H N N 325 
TRP HB3  H N N 326 
TRP HD1  H N N 327 
TRP HE1  H N N 328 
TRP HE3  H N N 329 
TRP HZ2  H N N 330 
TRP HZ3  H N N 331 
TRP HH2  H N N 332 
TRP HXT  H N N 333 
TYR N    N N N 334 
TYR CA   C N S 335 
TYR C    C N N 336 
TYR O    O N N 337 
TYR CB   C N N 338 
TYR CG   C Y N 339 
TYR CD1  C Y N 340 
TYR CD2  C Y N 341 
TYR CE1  C Y N 342 
TYR CE2  C Y N 343 
TYR CZ   C Y N 344 
TYR OH   O N N 345 
TYR OXT  O N N 346 
TYR H    H N N 347 
TYR H2   H N N 348 
TYR HA   H N N 349 
TYR HB2  H N N 350 
TYR HB3  H N N 351 
TYR HD1  H N N 352 
TYR HD2  H N N 353 
TYR HE1  H N N 354 
TYR HE2  H N N 355 
TYR HH   H N N 356 
TYR HXT  H N N 357 
VAL N    N N N 358 
VAL CA   C N S 359 
VAL C    C N N 360 
VAL O    O N N 361 
VAL CB   C N N 362 
VAL CG1  C N N 363 
VAL CG2  C N N 364 
VAL OXT  O N N 365 
VAL H    H N N 366 
VAL H2   H N N 367 
VAL HA   H N N 368 
VAL HB   H N N 369 
VAL HG11 H N N 370 
VAL HG12 H N N 371 
VAL HG13 H N N 372 
VAL HG21 H N N 373 
VAL HG22 H N N 374 
VAL HG23 H N N 375 
VAL HXT  H N N 376 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
THR N   CA   sing N N 277 
THR N   H    sing N N 278 
THR N   H2   sing N N 279 
THR CA  C    sing N N 280 
THR CA  CB   sing N N 281 
THR CA  HA   sing N N 282 
THR C   O    doub N N 283 
THR C   OXT  sing N N 284 
THR CB  OG1  sing N N 285 
THR CB  CG2  sing N N 286 
THR CB  HB   sing N N 287 
THR OG1 HG1  sing N N 288 
THR CG2 HG21 sing N N 289 
THR CG2 HG22 sing N N 290 
THR CG2 HG23 sing N N 291 
THR OXT HXT  sing N N 292 
TRP N   CA   sing N N 293 
TRP N   H    sing N N 294 
TRP N   H2   sing N N 295 
TRP CA  C    sing N N 296 
TRP CA  CB   sing N N 297 
TRP CA  HA   sing N N 298 
TRP C   O    doub N N 299 
TRP C   OXT  sing N N 300 
TRP CB  CG   sing N N 301 
TRP CB  HB2  sing N N 302 
TRP CB  HB3  sing N N 303 
TRP CG  CD1  doub Y N 304 
TRP CG  CD2  sing Y N 305 
TRP CD1 NE1  sing Y N 306 
TRP CD1 HD1  sing N N 307 
TRP CD2 CE2  doub Y N 308 
TRP CD2 CE3  sing Y N 309 
TRP NE1 CE2  sing Y N 310 
TRP NE1 HE1  sing N N 311 
TRP CE2 CZ2  sing Y N 312 
TRP CE3 CZ3  doub Y N 313 
TRP CE3 HE3  sing N N 314 
TRP CZ2 CH2  doub Y N 315 
TRP CZ2 HZ2  sing N N 316 
TRP CZ3 CH2  sing Y N 317 
TRP CZ3 HZ3  sing N N 318 
TRP CH2 HH2  sing N N 319 
TRP OXT HXT  sing N N 320 
TYR N   CA   sing N N 321 
TYR N   H    sing N N 322 
TYR N   H2   sing N N 323 
TYR CA  C    sing N N 324 
TYR CA  CB   sing N N 325 
TYR CA  HA   sing N N 326 
TYR C   O    doub N N 327 
TYR C   OXT  sing N N 328 
TYR CB  CG   sing N N 329 
TYR CB  HB2  sing N N 330 
TYR CB  HB3  sing N N 331 
TYR CG  CD1  doub Y N 332 
TYR CG  CD2  sing Y N 333 
TYR CD1 CE1  sing Y N 334 
TYR CD1 HD1  sing N N 335 
TYR CD2 CE2  doub Y N 336 
TYR CD2 HD2  sing N N 337 
TYR CE1 CZ   doub Y N 338 
TYR CE1 HE1  sing N N 339 
TYR CE2 CZ   sing Y N 340 
TYR CE2 HE2  sing N N 341 
TYR CZ  OH   sing N N 342 
TYR OH  HH   sing N N 343 
TYR OXT HXT  sing N N 344 
VAL N   CA   sing N N 345 
VAL N   H    sing N N 346 
VAL N   H2   sing N N 347 
VAL CA  C    sing N N 348 
VAL CA  CB   sing N N 349 
VAL CA  HA   sing N N 350 
VAL C   O    doub N N 351 
VAL C   OXT  sing N N 352 
VAL CB  CG1  sing N N 353 
VAL CB  CG2  sing N N 354 
VAL CB  HB   sing N N 355 
VAL CG1 HG11 sing N N 356 
VAL CG1 HG12 sing N N 357 
VAL CG1 HG13 sing N N 358 
VAL CG2 HG21 sing N N 359 
VAL CG2 HG22 sing N N 360 
VAL CG2 HG23 sing N N 361 
VAL OXT HXT  sing N N 362 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8Z5K 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 21 21 21' 
_space_group.name_Hall        'I 2b 2c' 
_space_group.IT_number        24 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8Z6N 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.015491 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013167 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009647 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 2   ? 27.90869  -11.77722 33.45558 1.000 39.40580 ? 39  SER A N   1 
ATOM   2    C CA  . SER A 1 2   ? 29.28682  -12.25245 33.38508 1.000 41.38412 ? 39  SER A CA  1 
ATOM   3    C C   . SER A 1 2   ? 29.75684  -12.39304 31.93640 1.000 35.93704 ? 39  SER A C   1 
ATOM   4    O O   . SER A 1 2   ? 30.93411  -12.64971 31.67870 1.000 37.48910 ? 39  SER A O   1 
ATOM   5    C CB  . SER A 1 2   ? 29.42616  -13.58891 34.11659 1.000 38.16260 ? 39  SER A CB  1 
ATOM   6    O OG  . SER A 1 2   ? 30.77868  -14.00460 34.16518 1.000 44.28058 ? 39  SER A OG  1 
ATOM   7    N N   . ILE A 1 3   ? 28.82924  -12.22175 30.99763 1.000 25.58615 ? 40  ILE A N   1 
ATOM   8    C CA  . ILE A 1 3   ? 29.10658  -12.31471 29.56856 1.000 26.18951 ? 40  ILE A CA  1 
ATOM   9    C C   . ILE A 1 3   ? 28.95676  -10.91819 28.98003 1.000 36.15720 ? 40  ILE A C   1 
ATOM   10   O O   . ILE A 1 3   ? 27.85024  -10.36584 28.94267 1.000 26.86413 ? 40  ILE A O   1 
ATOM   11   C CB  . ILE A 1 3   ? 28.17134  -13.30883 28.86694 1.000 34.46958 ? 40  ILE A CB  1 
ATOM   12   C CG1 . ILE A 1 3   ? 28.33934  -14.71625 29.44618 1.000 30.77245 ? 40  ILE A CG1 1 
ATOM   13   C CG2 . ILE A 1 3   ? 28.41837  -13.30181 27.36561 1.000 24.44358 ? 40  ILE A CG2 1 
ATOM   14   C CD1 . ILE A 1 3   ? 29.66392  -15.35701 29.12079 1.000 41.86972 ? 40  ILE A CD1 1 
ATOM   15   N N   . ALA A 1 4   ? 30.06316  -10.34250 28.51834 1.000 28.37198 ? 41  ALA A N   1 
ATOM   16   C CA  . ALA A 1 4   ? 30.01170  -9.04168  27.86804 1.000 23.17011 ? 41  ALA A CA  1 
ATOM   17   C C   . ALA A 1 4   ? 29.42771  -9.17632  26.46663 1.000 19.13150 ? 41  ALA A C   1 
ATOM   18   O O   . ALA A 1 4   ? 29.64945  -10.17152 25.77141 1.000 24.36171 ? 41  ALA A O   1 
ATOM   19   C CB  . ALA A 1 4   ? 31.40442  -8.41371  27.80687 1.000 15.89404 ? 41  ALA A CB  1 
ATOM   20   N N   . ARG A 1 5   ? 28.67038  -8.16179  26.05301 1.000 23.46955 ? 42  ARG A N   1 
ATOM   21   C CA  . ARG A 1 5   ? 27.90042  -8.23591  24.82090 1.000 32.60672 ? 42  ARG A CA  1 
ATOM   22   C C   . ARG A 1 5   ? 28.10482  -6.98922  23.97158 1.000 25.42342 ? 42  ARG A C   1 
ATOM   23   O O   . ARG A 1 5   ? 28.25155  -5.87742  24.48616 1.000 26.02498 ? 42  ARG A O   1 
ATOM   24   C CB  . ARG A 1 5   ? 26.40197  -8.42626  25.11450 1.000 35.29705 ? 42  ARG A CB  1 
ATOM   25   C CG  . ARG A 1 5   ? 26.08694  -9.71363  25.85742 1.000 30.63637 ? 42  ARG A CG  1 
ATOM   26   C CD  . ARG A 1 5   ? 24.59191  -9.93663  26.00312 1.000 61.63021 ? 42  ARG A CD  1 
ATOM   27   N NE  . ARG A 1 5   ? 23.87929  -9.76144  24.74036 1.000 62.71961 ? 42  ARG A NE  1 
ATOM   28   C CZ  . ARG A 1 5   ? 23.89517  -10.63871 23.74194 1.000 66.63389 ? 42  ARG A CZ  1 
ATOM   29   N NH1 . ARG A 1 5   ? 23.21104  -10.39399 22.63215 1.000 50.96576 ? 42  ARG A NH1 1 
ATOM   30   N NH2 . ARG A 1 5   ? 24.60082  -11.75666 23.84780 1.000 66.37964 ? 42  ARG A NH2 1 
ATOM   31   N N   . HIS A 1 6   ? 28.10762  -7.19858  22.65648 1.000 19.30590 ? 43  HIS A N   1 
ATOM   32   C CA  . HIS A 1 6   ? 28.16756  -6.09895  21.70411 1.000 17.68037 ? 43  HIS A CA  1 
ATOM   33   C C   . HIS A 1 6   ? 26.97217  -5.17165  21.89203 1.000 31.86166 ? 43  HIS A C   1 
ATOM   34   O O   . HIS A 1 6   ? 25.83989  -5.62443  22.08265 1.000 25.95500 ? 43  HIS A O   1 
ATOM   35   C CB  . HIS A 1 6   ? 28.19027  -6.65816  20.27924 1.000 17.94266 ? 43  HIS A CB  1 
ATOM   36   C CG  . HIS A 1 6   ? 28.67732  -5.68943  19.24660 1.000 22.52868 ? 43  HIS A CG  1 
ATOM   37   N ND1 . HIS A 1 6   ? 28.04227  -4.49476  18.98360 1.000 28.45446 ? 43  HIS A ND1 1 
ATOM   38   C CD2 . HIS A 1 6   ? 29.72821  -5.75151  18.39467 1.000 19.34385 ? 43  HIS A CD2 1 
ATOM   39   C CE1 . HIS A 1 6   ? 28.68755  -3.85684  18.02324 1.000 30.20403 ? 43  HIS A CE1 1 
ATOM   40   N NE2 . HIS A 1 6   ? 29.71451  -4.59832  17.64817 1.000 25.72080 ? 43  HIS A NE2 1 
ATOM   41   N N   . GLN A 1 7   ? 27.23000  -3.86128  21.83848 1.000 26.03996 ? 44  GLN A N   1 
ATOM   42   C CA  . GLN A 1 7   ? 26.16301  -2.88782  22.06057 1.000 26.21940 ? 44  GLN A CA  1 
ATOM   43   C C   . GLN A 1 7   ? 25.05946  -3.01710  21.01646 1.000 27.96933 ? 44  GLN A C   1 
ATOM   44   O O   . GLN A 1 7   ? 23.87466  -2.85432  21.33267 1.000 26.74835 ? 44  GLN A O   1 
ATOM   45   C CB  . GLN A 1 7   ? 26.73516  -1.46958  22.06759 1.000 24.83252 ? 44  GLN A CB  1 
ATOM   46   C CG  . GLN A 1 7   ? 27.44539  -1.10306  23.36024 1.000 29.04255 ? 44  GLN A CG  1 
ATOM   47   C CD  . GLN A 1 7   ? 26.52463  -1.16358  24.56381 1.000 34.91518 ? 44  GLN A CD  1 
ATOM   48   O OE1 . GLN A 1 7   ? 26.84310  -1.79147  25.57268 1.000 53.08324 ? 44  GLN A OE1 1 
ATOM   49   N NE2 . GLN A 1 7   ? 25.37422  -0.50730  24.46261 1.000 66.28366 ? 44  GLN A NE2 1 
ATOM   50   N N   . ASP A 1 8   ? 25.42587  -3.31081  19.76693 1.000 25.89182 ? 45  ASP A N   1 
ATOM   51   C CA  . ASP A 1 8   ? 24.41419  -3.52072  18.73603 1.000 25.41823 ? 45  ASP A CA  1 
ATOM   52   C C   . ASP A 1 8   ? 23.52687  -4.71280  19.07063 1.000 28.36929 ? 45  ASP A C   1 
ATOM   53   O O   . ASP A 1 8   ? 22.32288  -4.69657  18.79189 1.000 38.85469 ? 45  ASP A O   1 
ATOM   54   C CB  . ASP A 1 8   ? 25.07922  -3.71315  17.37345 1.000 27.57962 ? 45  ASP A CB  1 
ATOM   55   C CG  . ASP A 1 8   ? 25.83045  -2.48052  16.91429 1.000 41.46979 ? 45  ASP A CG  1 
ATOM   56   O OD1 . ASP A 1 8   ? 25.79827  -1.46335  17.63826 1.000 36.57719 ? 45  ASP A OD1 1 
ATOM   57   O OD2 . ASP A 1 8   ? 26.45282  -2.52861  15.83170 1.000 55.55419 ? 45  ASP A OD2 1 
ATOM   58   N N   . ASP A 1 9   ? 24.10089  -5.75519  19.67527 1.000 19.98455 ? 46  ASP A N   1 
ATOM   59   C CA  . ASP A 1 9   ? 23.29714  -6.90983  20.06105 1.000 28.52250 ? 46  ASP A CA  1 
ATOM   60   C C   . ASP A 1 9   ? 22.31312  -6.55553  21.16846 1.000 28.48540 ? 46  ASP A C   1 
ATOM   61   O O   . ASP A 1 9   ? 21.18158  -7.05226  21.18029 1.000 32.69922 ? 46  ASP A O   1 
ATOM   62   C CB  . ASP A 1 9   ? 24.20084  -8.06329  20.49318 1.000 24.70629 ? 46  ASP A CB  1 
ATOM   63   C CG  . ASP A 1 9   ? 24.90319  -8.72010  19.32271 1.000 41.10347 ? 46  ASP A CG  1 
ATOM   64   O OD1 . ASP A 1 9   ? 24.75390  -8.22362  18.18678 1.000 30.59453 ? 46  ASP A OD1 1 
ATOM   65   O OD2 . ASP A 1 9   ? 25.59947  -9.73426  19.53664 1.000 53.81884 ? 46  ASP A OD2 1 
ATOM   66   N N   . ILE A 1 10  ? 22.72109  -5.69693  22.10488 1.000 23.82645 ? 47  ILE A N   1 
ATOM   67   C CA  . ILE A 1 10  ? 21.81913  -5.30134  23.18161 1.000 32.89068 ? 47  ILE A CA  1 
ATOM   68   C C   . ILE A 1 10  ? 20.66366  -4.47423  22.63205 1.000 27.17067 ? 47  ILE A C   1 
ATOM   69   O O   . ILE A 1 10  ? 19.50316  -4.67503  23.01054 1.000 26.89401 ? 47  ILE A O   1 
ATOM   70   C CB  . ILE A 1 10  ? 22.59289  -4.54472  24.27676 1.000 21.46842 ? 47  ILE A CB  1 
ATOM   71   C CG1 . ILE A 1 10  ? 23.58779  -5.48040  24.96738 1.000 40.18096 ? 47  ILE A CG1 1 
ATOM   72   C CG2 . ILE A 1 10  ? 21.63381  -3.94010  25.29074 1.000 17.43797 ? 47  ILE A CG2 1 
ATOM   73   C CD1 . ILE A 1 10  ? 24.37051  -4.82612  26.08606 1.000 31.28533 ? 47  ILE A CD1 1 
ATOM   74   N N   . ALA A 1 11  ? 20.95900  -3.54029  21.72446 1.000 21.77114 ? 48  ALA A N   1 
ATOM   75   C CA  . ALA A 1 11  ? 19.90899  -2.71762  21.13633 1.000 21.77267 ? 48  ALA A CA  1 
ATOM   76   C C   . ALA A 1 11  ? 18.97410  -3.53867  20.25913 1.000 30.66671 ? 48  ALA A C   1 
ATOM   77   O O   . ALA A 1 11  ? 17.77471  -3.24683  20.19435 1.000 25.98200 ? 48  ALA A O   1 
ATOM   78   C CB  . ALA A 1 11  ? 20.52617  -1.57476  20.33100 1.000 15.59989 ? 48  ALA A CB  1 
ATOM   79   N N   . ILE A 1 12  ? 19.49808  -4.56151  19.58044 1.000 22.80265 ? 49  ILE A N   1 
ATOM   80   C CA  . ILE A 1 12  ? 18.64997  -5.41863  18.75763 1.000 22.44884 ? 49  ILE A CA  1 
ATOM   81   C C   . ILE A 1 12  ? 17.69912  -6.22817  19.63222 1.000 25.05246 ? 49  ILE A C   1 
ATOM   82   O O   . ILE A 1 12  ? 16.51497  -6.38359  19.30756 1.000 25.29299 ? 49  ILE A O   1 
ATOM   83   C CB  . ILE A 1 12  ? 19.51965  -6.32433  17.86547 1.000 30.85772 ? 49  ILE A CB  1 
ATOM   84   C CG1 . ILE A 1 12  ? 20.13653  -5.51641  16.72294 1.000 28.65934 ? 49  ILE A CG1 1 
ATOM   85   C CG2 . ILE A 1 12  ? 18.71154  -7.48906  17.31696 1.000 17.29692 ? 49  ILE A CG2 1 
ATOM   86   C CD1 . ILE A 1 12  ? 21.21859  -6.26106  15.97230 1.000 30.25808 ? 49  ILE A CD1 1 
ATOM   87   N N   . GLU A 1 13  ? 18.19708  -6.75418  20.75508 1.000 21.80810 ? 50  GLU A N   1 
ATOM   88   C CA  . GLU A 1 13  ? 17.33324  -7.49813  21.66580 1.000 23.11634 ? 50  GLU A CA  1 
ATOM   89   C C   . GLU A 1 13  ? 16.28694  -6.58957  22.29744 1.000 24.04578 ? 50  GLU A C   1 
ATOM   90   O O   . GLU A 1 13  ? 15.12569  -6.98510  22.45163 1.000 21.68950 ? 50  GLU A O   1 
ATOM   91   C CB  . GLU A 1 13  ? 18.16890  -8.18429  22.74524 1.000 17.91167 ? 50  GLU A CB  1 
ATOM   92   C CG  . GLU A 1 13  ? 19.10516  -9.25791  22.21639 1.000 47.79240 ? 50  GLU A CG  1 
ATOM   93   C CD  . GLU A 1 13  ? 19.84637  -9.98320  23.32282 1.000 68.92432 ? 50  GLU A CD  1 
ATOM   94   O OE1 . GLU A 1 13  ? 19.44810  -9.84309  24.49885 1.000 79.03458 ? 50  GLU A OE1 1 
ATOM   95   O OE2 . GLU A 1 13  ? 20.82775  -10.69289 23.01632 1.000 71.52913 ? 50  GLU A OE2 1 
ATOM   96   N N   . GLN A 1 14  ? 16.67946  -5.36933  22.67055 1.000 20.95865 ? 51  GLN A N   1 
ATOM   97   C CA  . GLN A 1 14  ? 15.71733  -4.42402  23.22531 1.000 22.66058 ? 51  GLN A CA  1 
ATOM   98   C C   . GLN A 1 14  ? 14.62444  -4.09747  22.21872 1.000 20.68651 ? 51  GLN A C   1 
ATOM   99   O O   . GLN A 1 14  ? 13.43949  -4.06102  22.56859 1.000 16.87090 ? 51  GLN A O   1 
ATOM   100  C CB  . GLN A 1 14  ? 16.42517  -3.14477  23.66441 1.000 29.71574 ? 51  GLN A CB  1 
ATOM   101  C CG  . GLN A 1 14  ? 17.20701  -3.26309  24.95348 1.000 27.72485 ? 51  GLN A CG  1 
ATOM   102  C CD  . GLN A 1 14  ? 17.83119  -1.94307  25.35580 1.000 33.10977 ? 51  GLN A CD  1 
ATOM   103  O OE1 . GLN A 1 14  ? 18.37432  -1.22235  24.51802 1.000 27.96171 ? 51  GLN A OE1 1 
ATOM   104  N NE2 . GLN A 1 14  ? 17.74204  -1.61010  26.63873 1.000 36.60486 ? 51  GLN A NE2 1 
ATOM   105  N N   . SER A 1 15  ? 15.00472  -3.85508  20.96194 1.000 17.60712 ? 52  SER A N   1 
ATOM   106  C CA  . SER A 1 15  ? 14.01590  -3.51418  19.94713 1.000 18.04800 ? 52  SER A CA  1 
ATOM   107  C C   . SER A 1 15  ? 13.02351  -4.65199  19.74265 1.000 22.70049 ? 52  SER A C   1 
ATOM   108  O O   . SER A 1 15  ? 11.81605  -4.41492  19.63054 1.000 17.18983 ? 52  SER A O   1 
ATOM   109  C CB  . SER A 1 15  ? 14.71059  -3.15613  18.63374 1.000 15.89384 ? 52  SER A CB  1 
ATOM   110  O OG  . SER A 1 15  ? 15.32924  -4.29065  18.05308 1.000 22.76209 ? 52  SER A OG  1 
ATOM   111  N N   . HIS A 1 16  ? 13.51049  -5.89665  19.70462 1.000 21.97449 ? 53  HIS A N   1 
ATOM   112  C CA  . HIS A 1 16  ? 12.60388  -7.03517  19.58024 1.000 22.63333 ? 53  HIS A CA  1 
ATOM   113  C C   . HIS A 1 16  ? 11.67800  -7.13434  20.78407 1.000 22.57856 ? 53  HIS A C   1 
ATOM   114  O O   . HIS A 1 16  ? 10.47964  -7.39914  20.63444 1.000 22.28182 ? 53  HIS A O   1 
ATOM   115  C CB  . HIS A 1 16  ? 13.39425  -8.33313  19.40966 1.000 14.24021 ? 53  HIS A CB  1 
ATOM   116  C CG  . HIS A 1 16  ? 13.80798  -8.60723  17.99751 1.000 23.84692 ? 53  HIS A CG  1 
ATOM   117  N ND1 . HIS A 1 16  ? 13.03926  -9.35179  17.12890 1.000 23.13274 ? 53  HIS A ND1 1 
ATOM   118  C CD2 . HIS A 1 16  ? 14.90926  -8.23672  17.30231 1.000 21.58081 ? 53  HIS A CD2 1 
ATOM   119  C CE1 . HIS A 1 16  ? 13.64855  -9.42693  15.95897 1.000 27.52786 ? 53  HIS A CE1 1 
ATOM   120  N NE2 . HIS A 1 16  ? 14.78539  -8.75905  16.03773 1.000 27.52323 ? 53  HIS A NE2 1 
ATOM   121  N N   . PHE A 1 17  ? 12.21695  -6.92146  21.98632 1.000 16.71388 ? 54  PHE A N   1 
ATOM   122  C CA  . PHE A 1 17  ? 11.39472  -6.97516  23.18923 1.000 16.28680 ? 54  PHE A CA  1 
ATOM   123  C C   . PHE A 1 17  ? 10.23560  -5.98874  23.11393 1.000 18.11158 ? 54  PHE A C   1 
ATOM   124  O O   . PHE A 1 17  ? 9.09599   -6.33487  23.44442 1.000 15.19330 ? 54  PHE A O   1 
ATOM   125  C CB  . PHE A 1 17  ? 12.25769  -6.69763  24.42097 1.000 15.27361 ? 54  PHE A CB  1 
ATOM   126  C CG  . PHE A 1 17  ? 11.47735  -6.59754  25.70111 1.000 22.32451 ? 54  PHE A CG  1 
ATOM   127  C CD1 . PHE A 1 17  ? 11.18279  -7.73404  26.43837 1.000 13.56150 ? 54  PHE A CD1 1 
ATOM   128  C CD2 . PHE A 1 17  ? 11.04560  -5.36534  26.17331 1.000 14.42405 ? 54  PHE A CD2 1 
ATOM   129  C CE1 . PHE A 1 17  ? 10.46501  -7.64678  27.61877 1.000 16.84444 ? 54  PHE A CE1 1 
ATOM   130  C CE2 . PHE A 1 17  ? 10.32796  -5.27086  27.35103 1.000 15.96807 ? 54  PHE A CE2 1 
ATOM   131  C CZ  . PHE A 1 17  ? 10.03725  -6.41388  28.07588 1.000 20.48935 ? 54  PHE A CZ  1 
ATOM   132  N N   . TYR A 1 18  ? 10.50212  -4.75819  22.66850 1.000 14.05243 ? 55  TYR A N   1 
ATOM   133  C CA  . TYR A 1 18  ? 9.48006   -3.71962  22.70387 1.000 22.36978 ? 55  TYR A CA  1 
ATOM   134  C C   . TYR A 1 18  ? 8.54521   -3.75342  21.50240 1.000 15.83736 ? 55  TYR A C   1 
ATOM   135  O O   . TYR A 1 18  ? 7.41523   -3.26650  21.60910 1.000 21.39168 ? 55  TYR A O   1 
ATOM   136  C CB  . TYR A 1 18  ? 10.13378  -2.34251  22.83790 1.000 16.29494 ? 55  TYR A CB  1 
ATOM   137  C CG  . TYR A 1 18  ? 10.64548  -2.09752  24.23738 1.000 20.91119 ? 55  TYR A CG  1 
ATOM   138  C CD1 . TYR A 1 18  ? 9.76051   -1.92016  25.29332 1.000 12.87857 ? 55  TYR A CD1 1 
ATOM   139  C CD2 . TYR A 1 18  ? 12.00837  -2.06776  24.51056 1.000 13.64937 ? 55  TYR A CD2 1 
ATOM   140  C CE1 . TYR A 1 18  ? 10.21504  -1.70874  26.58019 1.000 19.26956 ? 55  TYR A CE1 1 
ATOM   141  C CE2 . TYR A 1 18  ? 12.47334  -1.85758  25.79662 1.000 10.33056 ? 55  TYR A CE2 1 
ATOM   142  C CZ  . TYR A 1 18  ? 11.57058  -1.67862  26.82699 1.000 18.25949 ? 55  TYR A CZ  1 
ATOM   143  O OH  . TYR A 1 18  ? 12.01959  -1.46792  28.10945 1.000 19.37542 ? 55  TYR A OH  1 
ATOM   144  N N   . VAL A 1 19  ? 8.97147   -4.31527  20.36978 1.000 16.69655 ? 56  VAL A N   1 
ATOM   145  C CA  . VAL A 1 19  ? 8.01183   -4.58098  19.30346 1.000 23.19373 ? 56  VAL A CA  1 
ATOM   146  C C   . VAL A 1 19  ? 7.01292   -5.63942  19.75323 1.000 20.59763 ? 56  VAL A C   1 
ATOM   147  O O   . VAL A 1 19  ? 5.79942   -5.49145  19.56369 1.000 20.39366 ? 56  VAL A O   1 
ATOM   148  C CB  . VAL A 1 19  ? 8.73004   -4.99774  18.00693 1.000 26.92745 ? 56  VAL A CB  1 
ATOM   149  C CG1 . VAL A 1 19  ? 7.71102   -5.41856  16.95950 1.000 13.73126 ? 56  VAL A CG1 1 
ATOM   150  C CG2 . VAL A 1 19  ? 9.58404   -3.85936  17.47640 1.000 13.90404 ? 56  VAL A CG2 1 
ATOM   151  N N   . GLU A 1 20  ? 7.50413   -6.71351  20.37529 1.000 23.42779 ? 57  GLU A N   1 
ATOM   152  C CA  . GLU A 1 20  ? 6.61373   -7.77016  20.84303 1.000 28.25719 ? 57  GLU A CA  1 
ATOM   153  C C   . GLU A 1 20  ? 5.68159   -7.26530  21.93701 1.000 25.87871 ? 57  GLU A C   1 
ATOM   154  O O   . GLU A 1 20  ? 4.50411   -7.64173  21.98268 1.000 14.48107 ? 57  GLU A O   1 
ATOM   155  C CB  . GLU A 1 20  ? 7.43399   -8.95844  21.34033 1.000 14.38652 ? 57  GLU A CB  1 
ATOM   156  C CG  . GLU A 1 20  ? 8.25214   -9.63083  20.25722 1.000 31.38269 ? 57  GLU A CG  1 
ATOM   157  C CD  . GLU A 1 20  ? 9.31473   -10.54629 20.82473 1.000 51.32085 ? 57  GLU A CD  1 
ATOM   158  O OE1 . GLU A 1 20  ? 9.25367   -10.84248 22.03714 1.000 40.09196 ? 57  GLU A OE1 1 
ATOM   159  O OE2 . GLU A 1 20  ? 10.21342  -10.96213 20.06226 1.000 59.57208 ? 57  GLU A OE2 1 
ATOM   160  N N   . LYS A 1 21  ? 6.18929   -6.40931  22.82647 1.000 19.95989 ? 58  LYS A N   1 
ATOM   161  C CA  . LYS A 1 21  ? 5.34784   -5.86219  23.88518 1.000 14.47429 ? 58  LYS A CA  1 
ATOM   162  C C   . LYS A 1 21  ? 4.30628   -4.90055  23.32637 1.000 23.65012 ? 58  LYS A C   1 
ATOM   163  O O   . LYS A 1 21  ? 3.16737   -4.86415  23.80718 1.000 25.82342 ? 58  LYS A O   1 
ATOM   164  C CB  . LYS A 1 21  ? 6.21339   -5.17182  24.93759 1.000 24.61701 ? 58  LYS A CB  1 
ATOM   165  C CG  . LYS A 1 21  ? 6.86701   -6.13642  25.91006 1.000 21.32593 ? 58  LYS A CG  1 
ATOM   166  C CD  . LYS A 1 21  ? 5.81159   -6.95249  26.63474 1.000 23.71289 ? 58  LYS A CD  1 
ATOM   167  C CE  . LYS A 1 21  ? 6.41214   -7.79237  27.74226 1.000 13.83743 ? 58  LYS A CE  1 
ATOM   168  N NZ  . LYS A 1 21  ? 5.34911   -8.49184  28.51516 1.000 42.55212 ? 58  LYS A NZ  1 
ATOM   169  N N   . ALA A 1 22  ? 4.67702   -4.11217  22.31518 1.000 21.44942 ? 59  ALA A N   1 
ATOM   170  C CA  . ALA A 1 22  ? 3.71356   -3.21840  21.68186 1.000 17.15087 ? 59  ALA A CA  1 
ATOM   171  C C   . ALA A 1 22  ? 2.54861   -4.00445  21.09202 1.000 20.63988 ? 59  ALA A C   1 
ATOM   172  O O   . ALA A 1 22  ? 1.38141   -3.63443  21.26246 1.000 14.25262 ? 59  ALA A O   1 
ATOM   173  C CB  . ALA A 1 22  ? 4.40406   -2.38392  20.60288 1.000 10.69601 ? 59  ALA A CB  1 
ATOM   174  N N   . LEU A 1 23  ? 2.85043   -5.10117  20.39630 1.000 19.94230 ? 60  LEU A N   1 
ATOM   175  C CA  . LEU A 1 23  ? 1.79480   -5.94042  19.84172 1.000 12.71534 ? 60  LEU A CA  1 
ATOM   176  C C   . LEU A 1 23  ? 0.99057   -6.61704  20.94428 1.000 22.52113 ? 60  LEU A C   1 
ATOM   177  O O   . LEU A 1 23  ? -0.24091  -6.69256  20.86450 1.000 14.68093 ? 60  LEU A O   1 
ATOM   178  C CB  . LEU A 1 23  ? 2.40238   -6.97994  18.90085 1.000 13.56410 ? 60  LEU A CB  1 
ATOM   179  C CG  . LEU A 1 23  ? 3.13753   -6.39986  17.69147 1.000 14.11059 ? 60  LEU A CG  1 
ATOM   180  C CD1 . LEU A 1 23  ? 3.89378   -7.48374  16.93432 1.000 19.73868 ? 60  LEU A CD1 1 
ATOM   181  C CD2 . LEU A 1 23  ? 2.15537   -5.67995  16.77459 1.000 14.37440 ? 60  LEU A CD2 1 
ATOM   182  N N   . GLN A 1 24  ? 1.66862   -7.10152  21.98739 1.000 18.91268 ? 61  GLN A N   1 
ATOM   183  C CA  . GLN A 1 24  ? 0.98179   -7.82084  23.05476 1.000 14.24342 ? 61  GLN A CA  1 
ATOM   184  C C   . GLN A 1 24  ? 0.04156   -6.90216  23.82871 1.000 24.23677 ? 61  GLN A C   1 
ATOM   185  O O   . GLN A 1 24  ? -1.12627  -7.24207  24.05037 1.000 20.33649 ? 61  GLN A O   1 
ATOM   186  C CB  . GLN A 1 24  ? 2.00604   -8.46648  23.98717 1.000 24.02338 ? 61  GLN A CB  1 
ATOM   187  C CG  . GLN A 1 24  ? 1.40444   -9.18901  25.17964 1.000 36.32303 ? 61  GLN A CG  1 
ATOM   188  C CD  . GLN A 1 24  ? 2.46014   -9.83173  26.05875 1.000 54.64904 ? 61  GLN A CD  1 
ATOM   189  O OE1 . GLN A 1 24  ? 3.60636   -10.01195 25.64288 1.000 49.81054 ? 61  GLN A OE1 1 
ATOM   190  N NE2 . GLN A 1 24  ? 2.07965   -10.17784 27.28317 1.000 57.12534 ? 61  GLN A NE2 1 
ATOM   191  N N   . ASN A 1 25  ? 0.53141   -5.73122  24.24868 1.000 18.40141 ? 62  ASN A N   1 
ATOM   192  C CA  . ASN A 1 25  ? -0.32522  -4.78851  24.96505 1.000 16.58086 ? 62  ASN A CA  1 
ATOM   193  C C   . ASN A 1 25  ? -1.49088  -4.32934  24.09615 1.000 25.12895 ? 62  ASN A C   1 
ATOM   194  O O   . ASN A 1 25  ? -2.60544  -4.12475  24.59336 1.000 16.49497 ? 62  ASN A O   1 
ATOM   195  C CB  . ASN A 1 25  ? 0.48871   -3.58296  25.43809 1.000 11.25645 ? 62  ASN A CB  1 
ATOM   196  C CG  . ASN A 1 25  ? 1.65975   -3.97581  26.32084 1.000 31.02728 ? 62  ASN A CG  1 
ATOM   197  O OD1 . ASN A 1 25  ? 1.66309   -5.04430  26.93278 1.000 22.11443 ? 62  ASN A OD1 1 
ATOM   198  N ND2 . ASN A 1 25  ? 2.66236   -3.10745  26.39173 1.000 25.91251 ? 62  ASN A ND2 1 
ATOM   199  N N   . ARG A 1 26  ? -1.25143  -4.15836  22.79467 1.000 15.72310 ? 63  ARG A N   1 
ATOM   200  C CA  . ARG A 1 26  ? -2.32176  -3.75136  21.89131 1.000 12.01175 ? 63  ARG A CA  1 
ATOM   201  C C   . ARG A 1 26  ? -3.38597  -4.83648  21.77362 1.000 20.46031 ? 63  ARG A C   1 
ATOM   202  O O   . ARG A 1 26  ? -4.58475  -4.53623  21.72895 1.000 19.59976 ? 63  ARG A O   1 
ATOM   203  C CB  . ARG A 1 26  ? -1.73900  -3.41427  20.51968 1.000 10.62842 ? 63  ARG A CB  1 
ATOM   204  C CG  . ARG A 1 26  ? -2.67903  -2.66292  19.58997 1.000 15.55173 ? 63  ARG A CG  1 
ATOM   205  C CD  . ARG A 1 26  ? -1.94491  -2.29233  18.31432 1.000 22.60211 ? 63  ARG A CD  1 
ATOM   206  N NE  . ARG A 1 26  ? -2.80949  -1.66958  17.31865 1.000 19.99268 ? 63  ARG A NE  1 
ATOM   207  C CZ  . ARG A 1 26  ? -2.79829  -0.37423  17.02352 1.000 21.14236 ? 63  ARG A CZ  1 
ATOM   208  N NH1 . ARG A 1 26  ? -1.96646  0.44704   17.65204 1.000 19.84183 ? 63  ARG A NH1 1 
ATOM   209  N NH2 . ARG A 1 26  ? -3.61856  0.09865   16.09602 1.000 28.76296 ? 63  ARG A NH2 1 
ATOM   210  N N   . ARG A 1 27  ? -2.96694  -6.10357  21.72810 1.000 18.13300 ? 64  ARG A N   1 
ATOM   211  C CA  . ARG A 1 27  ? -3.92386  -7.20088  21.63097 1.000 23.12456 ? 64  ARG A CA  1 
ATOM   212  C C   . ARG A 1 27  ? -4.74531  -7.33027  22.90608 1.000 20.62496 ? 64  ARG A C   1 
ATOM   213  O O   . ARG A 1 27  ? -5.97817  -7.41234  22.85545 1.000 17.54472 ? 64  ARG A O   1 
ATOM   214  C CB  . ARG A 1 27  ? -3.19655  -8.51156  21.33325 1.000 11.99111 ? 64  ARG A CB  1 
ATOM   215  C CG  . ARG A 1 27  ? -2.60350  -8.59841  19.94233 1.000 22.88763 ? 64  ARG A CG  1 
ATOM   216  C CD  . ARG A 1 27  ? -1.78488  -9.87038  19.78185 1.000 26.65561 ? 64  ARG A CD  1 
ATOM   217  N NE  . ARG A 1 27  ? -2.58407  -11.06937 20.01673 1.000 23.29740 ? 64  ARG A NE  1 
ATOM   218  C CZ  . ARG A 1 27  ? -2.11880  -12.30977 19.91193 1.000 33.10521 ? 64  ARG A CZ  1 
ATOM   219  N NH1 . ARG A 1 27  ? -0.85372  -12.51901 19.57517 1.000 24.08537 ? 64  ARG A NH1 1 
ATOM   220  N NH2 . ARG A 1 27  ? -2.91886  -13.34221 20.14163 1.000 28.68138 ? 64  ARG A NH2 1 
ATOM   221  N N   . GLU A 1 28  ? -4.07526  -7.36113  24.06102 1.000 15.88267 ? 65  GLU A N   1 
ATOM   222  C CA  . GLU A 1 28  ? -4.78516  -7.52583  25.32489 1.000 24.58197 ? 65  GLU A CA  1 
ATOM   223  C C   . GLU A 1 28  ? -5.76896  -6.38771  25.55587 1.000 18.49023 ? 65  GLU A C   1 
ATOM   224  O O   . GLU A 1 28  ? -6.87202  -6.60402  26.07158 1.000 17.16466 ? 65  GLU A O   1 
ATOM   225  C CB  . GLU A 1 28  ? -3.78757  -7.61856  26.47998 1.000 24.56792 ? 65  GLU A CB  1 
ATOM   226  C CG  . GLU A 1 28  ? -2.78458  -8.75506  26.33888 1.000 49.88297 ? 65  GLU A CG  1 
ATOM   227  C CD  . GLU A 1 28  ? -3.45174  -10.11041 26.18790 1.000 60.42567 ? 65  GLU A CD  1 
ATOM   228  O OE1 . GLU A 1 28  ? -4.30254  -10.45577 27.03550 1.000 77.36541 ? 65  GLU A OE1 1 
ATOM   229  O OE2 . GLU A 1 28  ? -3.13222  -10.82665 25.21494 1.000 52.58862 ? 65  GLU A OE2 1 
ATOM   230  N N   . ASN A 1 29  ? -5.39420  -5.16842  25.16877 1.000 16.22404 ? 66  ASN A N   1 
ATOM   231  C CA  . ASN A 1 29  ? -6.29959  -4.04196  25.34884 1.000 16.67810 ? 66  ASN A CA  1 
ATOM   232  C C   . ASN A 1 29  ? -7.52206  -4.16304  24.44795 1.000 19.07607 ? 66  ASN A C   1 
ATOM   233  O O   . ASN A 1 29  ? -8.64784  -3.88899  24.88058 1.000 22.03892 ? 66  ASN A O   1 
ATOM   234  C CB  . ASN A 1 29  ? -5.57240  -2.72855  25.08418 1.000 24.13703 ? 66  ASN A CB  1 
ATOM   235  C CG  . ASN A 1 29  ? -6.50160  -1.54628  25.14936 1.000 41.43623 ? 66  ASN A CG  1 
ATOM   236  O OD1 . ASN A 1 29  ? -7.13771  -1.30692  26.17594 1.000 55.42343 ? 66  ASN A OD1 1 
ATOM   237  N ND2 . ASN A 1 29  ? -6.60301  -0.80548  24.05189 1.000 40.98099 ? 66  ASN A ND2 1 
ATOM   238  N N   . SER A 1 30  ? -7.32452  -4.56971  23.19229 1.000 13.83202 ? 67  SER A N   1 
ATOM   239  C CA  . SER A 1 30  ? -8.46514  -4.75341  22.30263 1.000 17.55839 ? 67  SER A CA  1 
ATOM   240  C C   . SER A 1 30  ? -9.33906  -5.91796  22.74671 1.000 15.34235 ? 67  SER A C   1 
ATOM   241  O O   . SER A 1 30  ? -10.54023 -5.93202  22.45609 1.000 14.42308 ? 67  SER A O   1 
ATOM   242  C CB  . SER A 1 30  ? -7.98942  -4.95953  20.86516 1.000 12.44806 ? 67  SER A CB  1 
ATOM   243  O OG  . SER A 1 30  ? -7.47680  -3.75578  20.32404 1.000 27.76657 ? 67  SER A OG  1 
ATOM   244  N N   . GLU A 1 31  ? -8.76215  -6.89513  23.45277 1.000 14.28620 ? 68  GLU A N   1 
ATOM   245  C CA  . GLU A 1 31  ? -9.55881  -8.01042  23.95520 1.000 21.68310 ? 68  GLU A CA  1 
ATOM   246  C C   . GLU A 1 31  ? -10.53055 -7.55185  25.03460 1.000 23.24743 ? 68  GLU A C   1 
ATOM   247  O O   . GLU A 1 31  ? -11.68808 -7.98774  25.06098 1.000 17.42738 ? 68  GLU A O   1 
ATOM   248  C CB  . GLU A 1 31  ? -8.64841  -9.11426  24.49257 1.000 12.92459 ? 68  GLU A CB  1 
ATOM   249  C CG  . GLU A 1 31  ? -7.91885  -9.91118  23.42264 1.000 18.30500 ? 68  GLU A CG  1 
ATOM   250  C CD  . GLU A 1 31  ? -7.05256  -11.01109 24.01263 1.000 32.21376 ? 68  GLU A CD  1 
ATOM   251  O OE1 . GLU A 1 31  ? -6.13034  -11.48385 23.31681 1.000 28.53162 ? 68  GLU A OE1 1 
ATOM   252  O OE2 . GLU A 1 31  ? -7.29336  -11.40286 25.17490 1.000 32.79316 ? 68  GLU A OE2 1 
ATOM   253  N N   . GLN A 1 32  ? -10.07616 -6.68077  25.93924 1.000 15.42669 ? 69  GLN A N   1 
ATOM   254  C CA  . GLN A 1 32  ? -10.97408 -6.13831  26.95302 1.000 23.53916 ? 69  GLN A CA  1 
ATOM   255  C C   . GLN A 1 32  ? -12.00023 -5.20224  26.33023 1.000 19.44659 ? 69  GLN A C   1 
ATOM   256  O O   . GLN A 1 32  ? -13.16042 -5.16910  26.75786 1.000 21.71525 ? 69  GLN A O   1 
ATOM   257  C CB  . GLN A 1 32  ? -10.17737 -5.40967  28.03409 1.000 24.04809 ? 69  GLN A CB  1 
ATOM   258  C CG  . GLN A 1 32  ? -9.37298  -6.31640  28.94315 1.000 27.06597 ? 69  GLN A CG  1 
ATOM   259  C CD  . GLN A 1 32  ? -8.81293  -5.57325  30.14011 1.000 48.66048 ? 69  GLN A CD  1 
ATOM   260  O OE1 . GLN A 1 32  ? -9.22391  -4.44980  30.43404 1.000 55.69041 ? 69  GLN A OE1 1 
ATOM   261  N NE2 . GLN A 1 32  ? -7.86877  -6.19528  30.83626 1.000 59.40484 ? 69  GLN A NE2 1 
ATOM   262  N N   . PHE A 1 33  ? -11.58758 -4.42907  25.32371 1.000 19.56332 ? 70  PHE A N   1 
ATOM   263  C CA  . PHE A 1 33  ? -12.52763 -3.56508  24.61863 1.000 18.36880 ? 70  PHE A CA  1 
ATOM   264  C C   . PHE A 1 33  ? -13.60668 -4.38665  23.92352 1.000 24.28813 ? 70  PHE A C   1 
ATOM   265  O O   . PHE A 1 33  ? -14.79419 -4.04155  23.97540 1.000 17.48597 ? 70  PHE A O   1 
ATOM   266  C CB  . PHE A 1 33  ? -11.77283 -2.69663  23.61215 1.000 16.28870 ? 70  PHE A CB  1 
ATOM   267  C CG  . PHE A 1 33  ? -12.57914 -1.55472  23.06604 1.000 15.97008 ? 70  PHE A CG  1 
ATOM   268  C CD1 . PHE A 1 33  ? -12.75861 -0.40021  23.80945 1.000 20.69961 ? 70  PHE A CD1 1 
ATOM   269  C CD2 . PHE A 1 33  ? -13.14644 -1.62968  21.80654 1.000 16.65436 ? 70  PHE A CD2 1 
ATOM   270  C CE1 . PHE A 1 33  ? -13.49502 0.65620   23.30996 1.000 16.68148 ? 70  PHE A CE1 1 
ATOM   271  C CE2 . PHE A 1 33  ? -13.88391 -0.57515  21.29968 1.000 26.32974 ? 70  PHE A CE2 1 
ATOM   272  C CZ  . PHE A 1 33  ? -14.05737 0.56937   22.05337 1.000 22.56465 ? 70  PHE A CZ  1 
ATOM   273  N N   . SER A 1 34  ? -13.20900 -5.48475  23.27569 1.000 11.30525 ? 71  SER A N   1 
ATOM   274  C CA  . SER A 1 34  ? -14.17220 -6.35667  22.61254 1.000 20.55174 ? 71  SER A CA  1 
ATOM   275  C C   . SER A 1 34  ? -15.14893 -6.95842  23.61492 1.000 23.76312 ? 71  SER A C   1 
ATOM   276  O O   . SER A 1 34  ? -16.35913 -7.01169  23.36364 1.000 14.61584 ? 71  SER A O   1 
ATOM   277  C CB  . SER A 1 34  ? -13.43049 -7.45817  21.85190 1.000 14.24151 ? 71  SER A CB  1 
ATOM   278  O OG  . SER A 1 34  ? -14.32912 -8.34923  21.21909 1.000 14.89876 ? 71  SER A OG  1 
ATOM   279  N N   . THR A 1 35  ? -14.63712 -7.41442  24.75958 1.000 15.29638 ? 72  THR A N   1 
ATOM   280  C CA  . THR A 1 35  ? -15.49476 -7.96836  25.80144 1.000 18.00501 ? 72  THR A CA  1 
ATOM   281  C C   . THR A 1 35  ? -16.44709 -6.91732  26.36250 1.000 26.28516 ? 72  THR A C   1 
ATOM   282  O O   . THR A 1 35  ? -17.58532 -7.23833  26.72713 1.000 19.13321 ? 72  THR A O   1 
ATOM   283  C CB  . THR A 1 35  ? -14.61805 -8.57494  26.90150 1.000 16.91332 ? 72  THR A CB  1 
ATOM   284  O OG1 . THR A 1 35  ? -14.42351 -9.97128  26.63720 1.000 30.79295 ? 72  THR A OG1 1 
ATOM   285  C CG2 . THR A 1 35  ? -15.22760 -8.39072  28.28041 1.000 31.82032 ? 72  THR A CG2 1 
ATOM   286  N N   . THR A 1 36  ? -16.00889 -5.65813  26.42066 1.000 18.39677 ? 73  THR A N   1 
ATOM   287  C CA  . THR A 1 36  ? -16.88172 -4.58752  26.88964 1.000 23.18218 ? 73  THR A CA  1 
ATOM   288  C C   . THR A 1 36  ? -18.07318 -4.40024  25.95718 1.000 16.42416 ? 73  THR A C   1 
ATOM   289  O O   . THR A 1 36  ? -19.19170 -4.12832  26.40935 1.000 19.50122 ? 73  THR A O   1 
ATOM   290  C CB  . THR A 1 36  ? -16.07939 -3.29111  27.01820 1.000 18.33894 ? 73  THR A CB  1 
ATOM   291  O OG1 . THR A 1 36  ? -15.15211 -3.41415  28.10186 1.000 23.05404 ? 73  THR A OG1 1 
ATOM   292  C CG2 . THR A 1 36  ? -16.99183 -2.10084  27.26729 1.000 20.49799 ? 73  THR A CG2 1 
ATOM   293  N N   . TYR A 1 37  ? -17.85742 -4.56482  24.65217 1.000 13.65420 ? 74  TYR A N   1 
ATOM   294  C CA  . TYR A 1 37  ? -18.93137 -4.36849  23.68831 1.000 17.06401 ? 74  TYR A CA  1 
ATOM   295  C C   . TYR A 1 37  ? -19.80206 -5.60852  23.51944 1.000 21.58811 ? 74  TYR A C   1 
ATOM   296  O O   . TYR A 1 37  ? -20.98621 -5.48261  23.18907 1.000 18.10226 ? 74  TYR A O   1 
ATOM   297  C CB  . TYR A 1 37  ? -18.34984 -3.95529  22.33698 1.000 15.95008 ? 74  TYR A CB  1 
ATOM   298  C CG  . TYR A 1 37  ? -18.41926 -2.47251  22.06098 1.000 20.89414 ? 74  TYR A CG  1 
ATOM   299  C CD1 . TYR A 1 37  ? -19.58350 -1.89326  21.57460 1.000 23.83289 ? 74  TYR A CD1 1 
ATOM   300  C CD2 . TYR A 1 37  ? -17.31955 -1.65287  22.27606 1.000 26.83448 ? 74  TYR A CD2 1 
ATOM   301  C CE1 . TYR A 1 37  ? -19.65390 -0.53955  21.31270 1.000 19.99121 ? 74  TYR A CE1 1 
ATOM   302  C CE2 . TYR A 1 37  ? -17.38001 -0.29804  22.01823 1.000 25.71984 ? 74  TYR A CE2 1 
ATOM   303  C CZ  . TYR A 1 37  ? -18.55039 0.25329   21.53677 1.000 27.11372 ? 74  TYR A CZ  1 
ATOM   304  O OH  . TYR A 1 37  ? -18.61720 1.60112   21.27617 1.000 29.59554 ? 74  TYR A OH  1 
ATOM   305  N N   . SER A 1 38  ? -19.25093 -6.80221  23.73665 1.000 15.62249 ? 75  SER A N   1 
ATOM   306  C CA  . SER A 1 38  ? -19.98740 -8.03315  23.47369 1.000 15.03891 ? 75  SER A CA  1 
ATOM   307  C C   . SER A 1 38  ? -20.64640 -8.62761  24.71126 1.000 14.38086 ? 75  SER A C   1 
ATOM   308  O O   . SER A 1 38  ? -21.72089 -9.22287  24.59318 1.000 14.44230 ? 75  SER A O   1 
ATOM   309  C CB  . SER A 1 38  ? -19.06576 -9.08347  22.84095 1.000 12.97497 ? 75  SER A CB  1 
ATOM   310  O OG  . SER A 1 38  ? -18.17466 -9.63433  23.79624 1.000 13.46567 ? 75  SER A OG  1 
ATOM   311  N N   . PHE A 1 39  ? -20.03588 -8.49914  25.89121 1.000 18.80036 ? 76  PHE A N   1 
ATOM   312  C CA  . PHE A 1 39  ? -20.66392 -8.96362  27.13064 1.000 15.29944 ? 76  PHE A CA  1 
ATOM   313  C C   . PHE A 1 39  ? -21.59939 -7.85373  27.59678 1.000 19.37377 ? 76  PHE A C   1 
ATOM   314  O O   . PHE A 1 39  ? -21.30543 -7.07667  28.50879 1.000 16.29637 ? 76  PHE A O   1 
ATOM   315  C CB  . PHE A 1 39  ? -19.62766 -9.31568  28.19217 1.000 19.88416 ? 76  PHE A CB  1 
ATOM   316  C CG  . PHE A 1 39  ? -18.70893 -10.44863 27.80937 1.000 25.52734 ? 76  PHE A CG  1 
ATOM   317  C CD1 . PHE A 1 39  ? -18.89217 -11.15793 26.63069 1.000 21.15221 ? 76  PHE A CD1 1 
ATOM   318  C CD2 . PHE A 1 39  ? -17.66120 -10.80790 28.64095 1.000 19.03184 ? 76  PHE A CD2 1 
ATOM   319  C CE1 . PHE A 1 39  ? -18.03998 -12.19088 26.28501 1.000 20.32563 ? 76  PHE A CE1 1 
ATOM   320  C CE2 . PHE A 1 39  ? -16.80764 -11.84112 28.30015 1.000 23.76799 ? 76  PHE A CE2 1 
ATOM   321  C CZ  . PHE A 1 39  ? -16.99932 -12.53427 27.12217 1.000 15.24720 ? 76  PHE A CZ  1 
ATOM   322  N N   . TRP A 1 40  ? -22.75702 -7.79351  26.94656 1.000 12.58645 ? 77  TRP A N   1 
ATOM   323  C CA  . TRP A 1 40  ? -23.64491 -6.63976  27.03597 1.000 17.30938 ? 77  TRP A CA  1 
ATOM   324  C C   . TRP A 1 40  ? -25.04394 -7.11217  26.67995 1.000 21.65247 ? 77  TRP A C   1 
ATOM   325  O O   . TRP A 1 40  ? -25.25302 -7.64494  25.58523 1.000 21.01381 ? 77  TRP A O   1 
ATOM   326  C CB  . TRP A 1 40  ? -23.16838 -5.54272  26.08292 1.000 14.07825 ? 77  TRP A CB  1 
ATOM   327  C CG  . TRP A 1 40  ? -23.97900 -4.28525  26.07072 1.000 19.16658 ? 77  TRP A CG  1 
ATOM   328  C CD1 . TRP A 1 40  ? -24.90515 -3.88793  26.98992 1.000 18.97367 ? 77  TRP A CD1 1 
ATOM   329  C CD2 . TRP A 1 40  ? -23.92769 -3.25161  25.07890 1.000 16.51326 ? 77  TRP A CD2 1 
ATOM   330  N NE1 . TRP A 1 40  ? -25.43226 -2.66921  26.63179 1.000 21.12710 ? 77  TRP A NE1 1 
ATOM   331  C CE2 . TRP A 1 40  ? -24.84875 -2.25859  25.46174 1.000 15.89034 ? 77  TRP A CE2 1 
ATOM   332  C CE3 . TRP A 1 40  ? -23.19026 -3.07099  23.90410 1.000 14.48801 ? 77  TRP A CE3 1 
ATOM   333  C CZ2 . TRP A 1 40  ? -25.05555 -1.10426  24.70971 1.000 18.44291 ? 77  TRP A CZ2 1 
ATOM   334  C CZ3 . TRP A 1 40  ? -23.39333 -1.92213  23.16145 1.000 13.08319 ? 77  TRP A CZ3 1 
ATOM   335  C CH2 . TRP A 1 40  ? -24.31708 -0.95285  23.56738 1.000 18.27967 ? 77  TRP A CH2 1 
ATOM   336  N N   . THR A 1 41  ? -25.99491 -6.92990  27.59768 1.000 17.31418 ? 78  THR A N   1 
ATOM   337  C CA  . THR A 1 41  ? -27.34051 -7.45032  27.37245 1.000 19.02431 ? 78  THR A CA  1 
ATOM   338  C C   . THR A 1 41  ? -28.00531 -6.78311  26.17178 1.000 16.86442 ? 78  THR A C   1 
ATOM   339  O O   . THR A 1 41  ? -28.65389 -7.45665  25.36217 1.000 20.63275 ? 78  THR A O   1 
ATOM   340  C CB  . THR A 1 41  ? -28.18925 -7.27550  28.63215 1.000 15.67621 ? 78  THR A CB  1 
ATOM   341  O OG1 . THR A 1 41  ? -27.59942 -8.01275  29.71198 1.000 11.99379 ? 78  THR A OG1 1 
ATOM   342  C CG2 . THR A 1 41  ? -29.60367 -7.78522  28.39969 1.000 19.28763 ? 78  THR A CG2 1 
ATOM   343  N N   . ASP A 1 42  ? -27.85275 -5.46246  26.03357 1.000 15.11976 ? 79  ASP A N   1 
ATOM   344  C CA  . ASP A 1 42  ? -28.42359 -4.77569  24.87693 1.000 18.47930 ? 79  ASP A CA  1 
ATOM   345  C C   . ASP A 1 42  ? -27.81600 -5.28704  23.57780 1.000 22.49590 ? 79  ASP A C   1 
ATOM   346  O O   . ASP A 1 42  ? -28.52245 -5.44888  22.57564 1.000 17.73160 ? 79  ASP A O   1 
ATOM   347  C CB  . ASP A 1 42  ? -28.22096 -3.26493  24.99700 1.000 22.66102 ? 79  ASP A CB  1 
ATOM   348  C CG  . ASP A 1 42  ? -29.00325 -2.66021  26.14357 1.000 44.25394 ? 79  ASP A CG  1 
ATOM   349  O OD1 . ASP A 1 42  ? -30.10167 -3.17410  26.44547 1.000 29.48387 ? 79  ASP A OD1 1 
ATOM   350  O OD2 . ASP A 1 42  ? -28.51599 -1.67586  26.74530 1.000 33.07331 ? 79  ASP A OD2 1 
ATOM   351  N N   . ALA A 1 43  ? -26.50338 -5.53835  23.57172 1.000 16.87833 ? 80  ALA A N   1 
ATOM   352  C CA  . ALA A 1 43  ? -25.87555 -6.12001  22.39076 1.000 19.76541 ? 80  ALA A CA  1 
ATOM   353  C C   . ALA A 1 43  ? -26.44608 -7.50056  22.09637 1.000 21.17944 ? 80  ALA A C   1 
ATOM   354  O O   . ALA A 1 43  ? -26.68068 -7.84876  20.93362 1.000 16.65257 ? 80  ALA A O   1 
ATOM   355  C CB  . ALA A 1 43  ? -24.35978 -6.19000  22.57582 1.000 13.69675 ? 80  ALA A CB  1 
ATOM   356  N N   . TYR A 1 44  ? -26.68899 -8.29641  23.14110 1.000 17.08284 ? 81  TYR A N   1 
ATOM   357  C CA  . TYR A 1 44  ? -27.28106 -9.61461  22.94259 1.000 20.54741 ? 81  TYR A CA  1 
ATOM   358  C C   . TYR A 1 44  ? -28.66777 -9.50948  22.32086 1.000 21.56831 ? 81  TYR A C   1 
ATOM   359  O O   . TYR A 1 44  ? -29.01616 -10.28931 21.42760 1.000 24.84338 ? 81  TYR A O   1 
ATOM   360  C CB  . TYR A 1 44  ? -27.34434 -10.36756 24.27101 1.000 21.48058 ? 81  TYR A CB  1 
ATOM   361  C CG  . TYR A 1 44  ? -28.04257 -11.70338 24.17502 1.000 25.65278 ? 81  TYR A CG  1 
ATOM   362  C CD1 . TYR A 1 44  ? -27.38416 -12.81693 23.67013 1.000 27.06643 ? 81  TYR A CD1 1 
ATOM   363  C CD2 . TYR A 1 44  ? -29.36174 -11.85168 24.58721 1.000 21.76517 ? 81  TYR A CD2 1 
ATOM   364  C CE1 . TYR A 1 44  ? -28.01949 -14.04214 23.57704 1.000 26.46254 ? 81  TYR A CE1 1 
ATOM   365  C CE2 . TYR A 1 44  ? -30.00585 -13.07199 24.49800 1.000 18.87972 ? 81  TYR A CE2 1 
ATOM   366  C CZ  . TYR A 1 44  ? -29.32985 -14.16327 23.99239 1.000 39.15804 ? 81  TYR A CZ  1 
ATOM   367  O OH  . TYR A 1 44  ? -29.96482 -15.38006 23.90322 1.000 33.25925 ? 81  TYR A OH  1 
ATOM   368  N N   . VAL A 1 45  ? -29.46748 -8.54154  22.76958 1.000 22.61650 ? 82  VAL A N   1 
ATOM   369  C CA  . VAL A 1 45  ? -30.83893 -8.42232  22.28307 1.000 27.74990 ? 82  VAL A CA  1 
ATOM   370  C C   . VAL A 1 45  ? -30.85562 -7.99453  20.82140 1.000 21.99288 ? 82  VAL A C   1 
ATOM   371  O O   . VAL A 1 45  ? -31.57549 -8.56916  19.99629 1.000 20.64571 ? 82  VAL A O   1 
ATOM   372  C CB  . VAL A 1 45  ? -31.63564 -7.44094  23.16182 1.000 22.83476 ? 82  VAL A CB  1 
ATOM   373  C CG1 . VAL A 1 45  ? -32.99020 -7.14663  22.53470 1.000 20.54089 ? 82  VAL A CG1 1 
ATOM   374  C CG2 . VAL A 1 45  ? -31.80685 -8.00359  24.55638 1.000 16.78388 ? 82  VAL A CG2 1 
ATOM   375  N N   . TYR A 1 46  ? -30.06281 -6.98209  20.47848 1.000 19.31286 ? 83  TYR A N   1 
ATOM   376  C CA  . TYR A 1 46  ? -30.16058 -6.33746  19.17817 1.000 18.44211 ? 83  TYR A CA  1 
ATOM   377  C C   . TYR A 1 46  ? -29.14892 -6.85004  18.16151 1.000 27.97710 ? 83  TYR A C   1 
ATOM   378  O O   . TYR A 1 46  ? -29.28100 -6.53408  16.97361 1.000 18.86778 ? 83  TYR A O   1 
ATOM   379  C CB  . TYR A 1 46  ? -30.01689 -4.81965  19.34390 1.000 19.30657 ? 83  TYR A CB  1 
ATOM   380  C CG  . TYR A 1 46  ? -31.15887 -4.21493  20.13046 1.000 25.31833 ? 83  TYR A CG  1 
ATOM   381  C CD1 . TYR A 1 46  ? -32.32152 -3.80546  19.49414 1.000 22.44173 ? 83  TYR A CD1 1 
ATOM   382  C CD2 . TYR A 1 46  ? -31.08486 -4.07766  21.51155 1.000 22.97283 ? 83  TYR A CD2 1 
ATOM   383  C CE1 . TYR A 1 46  ? -33.37450 -3.26393  20.20700 1.000 24.99299 ? 83  TYR A CE1 1 
ATOM   384  C CE2 . TYR A 1 46  ? -32.13114 -3.53623  22.23269 1.000 17.94592 ? 83  TYR A CE2 1 
ATOM   385  C CZ  . TYR A 1 46  ? -33.27514 -3.13204  21.57407 1.000 25.51572 ? 83  TYR A CZ  1 
ATOM   386  O OH  . TYR A 1 46  ? -34.32533 -2.59309  22.28098 1.000 25.03228 ? 83  TYR A OH  1 
ATOM   387  N N   . LEU A 1 47  ? -28.16008 -7.63814  18.58751 1.000 22.30624 ? 84  LEU A N   1 
ATOM   388  C CA  . LEU A 1 47  ? -27.16710 -8.19820  17.67725 1.000 19.19422 ? 84  LEU A CA  1 
ATOM   389  C C   . LEU A 1 47  ? -26.99408 -9.70462  17.78940 1.000 21.57782 ? 84  LEU A C   1 
ATOM   390  O O   . LEU A 1 47  ? -26.53688 -10.32093 16.81957 1.000 37.22248 ? 84  LEU A O   1 
ATOM   391  C CB  . LEU A 1 47  ? -25.79818 -7.53869  17.90081 1.000 25.40406 ? 84  LEU A CB  1 
ATOM   392  C CG  . LEU A 1 47  ? -25.71659 -6.02701  17.70161 1.000 24.78544 ? 84  LEU A CG  1 
ATOM   393  C CD1 . LEU A 1 47  ? -24.34198 -5.52178  18.10856 1.000 33.95521 ? 84  LEU A CD1 1 
ATOM   394  C CD2 . LEU A 1 47  ? -26.01775 -5.66937  16.25967 1.000 21.93015 ? 84  LEU A CD2 1 
ATOM   395  N N   . GLY A 1 48  ? -27.33031 -10.31680 18.92551 1.000 31.19803 ? 85  GLY A N   1 
ATOM   396  C CA  . GLY A 1 48  ? -27.13002 -11.74108 19.12214 1.000 36.65738 ? 85  GLY A CA  1 
ATOM   397  C C   . GLY A 1 48  ? -28.10726 -12.64279 18.40166 1.000 52.76897 ? 85  GLY A C   1 
ATOM   398  O O   . GLY A 1 48  ? -27.86658 -13.85038 18.31807 1.000 63.77998 ? 85  GLY A O   1 
ATOM   399  N N   . ASN A 1 49  ? -29.20480 -12.09359 17.88740 1.000 38.83659 ? 86  ASN A N   1 
ATOM   400  C CA  . ASN A 1 49  ? -30.17607 -12.87929 17.13661 1.000 64.53218 ? 86  ASN A CA  1 
ATOM   401  C C   . ASN A 1 49  ? -30.29088 -12.32128 15.72515 1.000 73.35461 ? 86  ASN A C   1 
ATOM   402  O O   . ASN A 1 49  ? -29.41015 -12.54856 14.88776 1.000 65.96787 ? 86  ASN A O   1 
ATOM   403  C CB  . ASN A 1 49  ? -31.53361 -12.86833 17.83985 1.000 75.05832 ? 86  ASN A CB  1 
ATOM   404  C CG  . ASN A 1 49  ? -31.43573 -13.29105 19.28894 1.000 74.78320 ? 86  ASN A CG  1 
ATOM   405  O OD1 . ASN A 1 49  ? -31.64078 -12.48408 20.19647 1.000 56.35140 ? 86  ASN A OD1 1 
ATOM   406  N ND2 . ASN A 1 49  ? -31.09522 -14.55891 19.51671 1.000 55.01511 ? 86  ASN A ND2 1 
ATOM   407  N N   . ARG A 1 50  ? -31.36689 -11.58644 15.45381 1.000 62.13535 ? 87  ARG A N   1 
ATOM   408  C CA  . ARG A 1 50  ? -31.44721 -10.79800 14.23417 1.000 59.05596 ? 87  ARG A CA  1 
ATOM   409  C C   . ARG A 1 50  ? -30.71644 -9.47918  14.44207 1.000 43.42876 ? 87  ARG A C   1 
ATOM   410  O O   . ARG A 1 50  ? -30.87542 -8.82037  15.47358 1.000 52.56379 ? 87  ARG A O   1 
ATOM   411  C CB  . ARG A 1 50  ? -32.90318 -10.54579 13.84029 1.000 53.20022 ? 87  ARG A CB  1 
ATOM   412  C CG  . ARG A 1 50  ? -33.07169 -9.81117  12.50976 1.000 55.88045 ? 87  ARG A CG  1 
ATOM   413  C CD  . ARG A 1 50  ? -33.42342 -8.34744  12.71932 1.000 62.13394 ? 87  ARG A CD  1 
ATOM   414  N NE  . ARG A 1 50  ? -34.66600 -8.19266  13.46980 1.000 89.91751 ? 87  ARG A NE  1 
ATOM   415  C CZ  . ARG A 1 50  ? -35.18977 -7.02194  13.81863 1.000 81.66151 ? 87  ARG A CZ  1 
ATOM   416  N NH1 . ARG A 1 50  ? -34.57882 -5.89162  13.48525 1.000 52.39451 ? 87  ARG A NH1 1 
ATOM   417  N NH2 . ARG A 1 50  ? -36.32536 -6.98227  14.50362 1.000 59.53863 ? 87  ARG A NH2 1 
ATOM   418  N N   . VAL A 1 51  ? -29.90430 -9.10080  13.46188 1.000 36.73982 ? 88  VAL A N   1 
ATOM   419  C CA  . VAL A 1 51  ? -29.05372 -7.92331  13.59466 1.000 34.82108 ? 88  VAL A CA  1 
ATOM   420  C C   . VAL A 1 51  ? -29.87399 -6.67411  13.30469 1.000 29.10585 ? 88  VAL A C   1 
ATOM   421  O O   . VAL A 1 51  ? -30.33635 -6.46426  12.17784 1.000 35.32901 ? 88  VAL A O   1 
ATOM   422  C CB  . VAL A 1 51  ? -27.83345 -8.01242  12.66962 1.000 32.68000 ? 88  VAL A CB  1 
ATOM   423  C CG1 . VAL A 1 51  ? -27.13510 -6.66839  12.59129 1.000 22.16681 ? 88  VAL A CG1 1 
ATOM   424  C CG2 . VAL A 1 51  ? -26.87942 -9.07514  13.17559 1.000 35.18802 ? 88  VAL A CG2 1 
ATOM   425  N N   . ASP A 1 52  ? -30.04943 -5.83777  14.32215 1.000 20.35959 ? 89  ASP A N   1 
ATOM   426  C CA  . ASP A 1 52  ? -30.72917 -4.55274  14.18351 1.000 21.46847 ? 89  ASP A CA  1 
ATOM   427  C C   . ASP A 1 52  ? -29.67056 -3.51874  13.81949 1.000 22.36940 ? 89  ASP A C   1 
ATOM   428  O O   . ASP A 1 52  ? -29.00803 -2.94309  14.68446 1.000 23.14732 ? 89  ASP A O   1 
ATOM   429  C CB  . ASP A 1 52  ? -31.46517 -4.20010  15.47191 1.000 22.22025 ? 89  ASP A CB  1 
ATOM   430  C CG  . ASP A 1 52  ? -32.38815 -3.00789  15.31894 1.000 20.33452 ? 89  ASP A CG  1 
ATOM   431  O OD1 . ASP A 1 52  ? -32.15936 -2.17098  14.42023 1.000 19.40074 ? 89  ASP A OD1 1 
ATOM   432  O OD2 . ASP A 1 52  ? -33.34742 -2.90595  16.11231 1.000 33.13056 ? 89  ASP A OD2 1 
ATOM   433  N N   . ALA A 1 53  ? -29.49973 -3.29018  12.51443 1.000 15.60899 ? 90  ALA A N   1 
ATOM   434  C CA  . ALA A 1 53  ? -28.54154 -2.29362  12.04967 1.000 18.00665 ? 90  ALA A CA  1 
ATOM   435  C C   . ALA A 1 53  ? -28.96743 -0.87462  12.40045 1.000 24.43020 ? 90  ALA A C   1 
ATOM   436  O O   . ALA A 1 53  ? -28.11645 0.02087   12.44798 1.000 22.16850 ? 90  ALA A O   1 
ATOM   437  C CB  . ALA A 1 53  ? -28.33791 -2.41613  10.53926 1.000 12.25913 ? 90  ALA A CB  1 
ATOM   438  N N   . ASP A 1 54  ? -30.26154 -0.64799  12.63434 1.000 17.18322 ? 91  ASP A N   1 
ATOM   439  C CA  . ASP A 1 54  ? -30.71308 0.66074   13.09393 1.000 21.38377 ? 91  ASP A CA  1 
ATOM   440  C C   . ASP A 1 54  ? -30.19276 0.94999   14.49675 1.000 18.78773 ? 91  ASP A C   1 
ATOM   441  O O   . ASP A 1 54  ? -29.66850 2.03699   14.76826 1.000 22.73808 ? 91  ASP A O   1 
ATOM   442  C CB  . ASP A 1 54  ? -32.24085 0.72705   13.05516 1.000 20.48874 ? 91  ASP A CB  1 
ATOM   443  C CG  . ASP A 1 54  ? -32.78513 1.98331   13.69958 1.000 22.01162 ? 91  ASP A CG  1 
ATOM   444  O OD1 . ASP A 1 54  ? -32.75422 3.04791   13.04740 1.000 33.21945 ? 91  ASP A OD1 1 
ATOM   445  O OD2 . ASP A 1 54  ? -33.23836 1.90599   14.86189 1.000 36.22888 ? 91  ASP A OD2 1 
ATOM   446  N N   . TRP A 1 55  ? -30.32850 -0.01922  15.40185 1.000 18.26535 ? 92  TRP A N   1 
ATOM   447  C CA  . TRP A 1 55  ? -29.76935 0.12754   16.74041 1.000 26.57948 ? 92  TRP A CA  1 
ATOM   448  C C   . TRP A 1 55  ? -28.24639 0.19637   16.69905 1.000 20.73889 ? 92  TRP A C   1 
ATOM   449  O O   . TRP A 1 55  ? -27.63672 0.99938   17.41337 1.000 18.28671 ? 92  TRP A O   1 
ATOM   450  C CB  . TRP A 1 55  ? -30.23786 -1.03249  17.61859 1.000 15.36124 ? 92  TRP A CB  1 
ATOM   451  C CG  . TRP A 1 55  ? -29.66615 -1.04435  19.00417 1.000 30.02082 ? 92  TRP A CG  1 
ATOM   452  C CD1 . TRP A 1 55  ? -30.20101 -0.46157  20.11485 1.000 23.75420 ? 92  TRP A CD1 1 
ATOM   453  C CD2 . TRP A 1 55  ? -28.45883 -1.69044  19.43194 1.000 25.27399 ? 92  TRP A CD2 1 
ATOM   454  N NE1 . TRP A 1 55  ? -29.39977 -0.69721  21.20578 1.000 21.04224 ? 92  TRP A NE1 1 
ATOM   455  C CE2 . TRP A 1 55  ? -28.32390 -1.44939  20.81371 1.000 26.97566 ? 92  TRP A CE2 1 
ATOM   456  C CE3 . TRP A 1 55  ? -27.47860 -2.44645  18.78010 1.000 25.95280 ? 92  TRP A CE3 1 
ATOM   457  C CZ2 . TRP A 1 55  ? -27.24721 -1.93633  21.55668 1.000 23.42951 ? 92  TRP A CZ2 1 
ATOM   458  C CZ3 . TRP A 1 55  ? -26.41090 -2.92945  19.51870 1.000 20.21574 ? 92  TRP A CZ3 1 
ATOM   459  C CH2 . TRP A 1 55  ? -26.30381 -2.67154  20.89266 1.000 17.47454 ? 92  TRP A CH2 1 
ATOM   460  N N   . ALA A 1 56  ? -27.61729 -0.62213  15.85268 1.000 16.54438 ? 93  ALA A N   1 
ATOM   461  C CA  . ALA A 1 56  ? -26.16119 -0.72114  15.85581 1.000 18.77106 ? 93  ALA A CA  1 
ATOM   462  C C   . ALA A 1 56  ? -25.51558 0.49903   15.20881 1.000 22.35637 ? 93  ALA A C   1 
ATOM   463  O O   . ALA A 1 56  ? -24.63897 1.13730   15.80307 1.000 18.34445 ? 93  ALA A O   1 
ATOM   464  C CB  . ALA A 1 56  ? -25.72335 -2.00363  15.14707 1.000 18.56127 ? 93  ALA A CB  1 
ATOM   465  N N   . PHE A 1 57  ? -25.93589 0.84237   13.99193 1.000 16.56940 ? 94  PHE A N   1 
ATOM   466  C CA  . PHE A 1 57  ? -25.28757 1.89703   13.22283 1.000 16.12081 ? 94  PHE A CA  1 
ATOM   467  C C   . PHE A 1 57  ? -26.00956 3.23617   13.32253 1.000 20.47586 ? 94  PHE A C   1 
ATOM   468  O O   . PHE A 1 57  ? -25.39008 4.24746   13.66904 1.000 14.49842 ? 94  PHE A O   1 
ATOM   469  C CB  . PHE A 1 57  ? -25.16922 1.47279   11.75247 1.000 18.61371 ? 94  PHE A CB  1 
ATOM   470  C CG  . PHE A 1 57  ? -24.18421 2.29023   10.96521 1.000 17.72349 ? 94  PHE A CG  1 
ATOM   471  C CD1 . PHE A 1 57  ? -22.82723 2.00359   11.01799 1.000 15.56404 ? 94  PHE A CD1 1 
ATOM   472  C CD2 . PHE A 1 57  ? -24.61227 3.34553   10.17528 1.000 14.46006 ? 94  PHE A CD2 1 
ATOM   473  C CE1 . PHE A 1 57  ? -21.91421 2.75496   10.29558 1.000 18.86029 ? 94  PHE A CE1 1 
ATOM   474  C CE2 . PHE A 1 57  ? -23.70576 4.10280   9.44912  1.000 15.01119 ? 94  PHE A CE2 1 
ATOM   475  C CZ  . PHE A 1 57  ? -22.35547 3.80793   9.50969  1.000 21.87318 ? 94  PHE A CZ  1 
ATOM   476  N N   . THR A 1 58  ? -27.31184 3.26348   13.02390 1.000 21.44171 ? 95  THR A N   1 
ATOM   477  C CA  . THR A 1 58  ? -28.04970 4.52463   13.03002 1.000 17.85077 ? 95  THR A CA  1 
ATOM   478  C C   . THR A 1 58  ? -28.07551 5.14688   14.42082 1.000 12.39658 ? 95  THR A C   1 
ATOM   479  O O   . THR A 1 58  ? -27.91981 6.36475   14.56532 1.000 23.82831 ? 95  THR A O   1 
ATOM   480  C CB  . THR A 1 58  ? -29.47306 4.30448   12.51189 1.000 28.06441 ? 95  THR A CB  1 
ATOM   481  O OG1 . THR A 1 58  ? -29.42038 3.73969   11.19631 1.000 25.53984 ? 95  THR A OG1 1 
ATOM   482  C CG2 . THR A 1 58  ? -30.23617 5.61979   12.45553 1.000 14.33837 ? 95  THR A CG2 1 
ATOM   483  N N   . LYS A 1 59  ? -28.26184 4.32971   15.45550 1.000 14.90864 ? 96  LYS A N   1 
ATOM   484  C CA  . LYS A 1 59  ? -28.25034 4.80676   16.83218 1.000 19.30874 ? 96  LYS A CA  1 
ATOM   485  C C   . LYS A 1 59  ? -26.86849 4.73995   17.47366 1.000 24.84670 ? 96  LYS A C   1 
ATOM   486  O O   . LYS A 1 59  ? -26.74483 5.01305   18.67269 1.000 17.81365 ? 96  LYS A O   1 
ATOM   487  C CB  . LYS A 1 59  ? -29.25512 4.01394   17.67454 1.000 28.70600 ? 96  LYS A CB  1 
ATOM   488  C CG  . LYS A 1 59  ? -30.68438 4.11330   17.16997 1.000 27.26955 ? 96  LYS A CG  1 
ATOM   489  C CD  . LYS A 1 59  ? -31.67875 3.62331   18.20763 1.000 41.60097 ? 96  LYS A CD  1 
ATOM   490  C CE  . LYS A 1 59  ? -33.09615 3.64573   17.65724 1.000 52.83659 ? 96  LYS A CE  1 
ATOM   491  N NZ  . LYS A 1 59  ? -33.43629 4.96444   17.05420 1.000 43.57161 ? 96  LYS A NZ  1 
ATOM   492  N N   . ASN A 1 60  ? -25.84062 4.36338   16.71036 1.000 17.38847 ? 97  ASN A N   1 
ATOM   493  C CA  . ASN A 1 60  ? -24.43999 4.48145   17.12258 1.000 24.59684 ? 97  ASN A CA  1 
ATOM   494  C C   . ASN A 1 60  ? -24.11944 3.67551   18.37882 1.000 15.82633 ? 97  ASN A C   1 
ATOM   495  O O   . ASN A 1 60  ? -23.22256 4.03522   19.14346 1.000 15.99126 ? 97  ASN A O   1 
ATOM   496  C CB  . ASN A 1 60  ? -24.04455 5.94713   17.32483 1.000 23.58729 ? 97  ASN A CB  1 
ATOM   497  C CG  . ASN A 1 60  ? -23.89633 6.69624   16.01801 1.000 23.61750 ? 97  ASN A CG  1 
ATOM   498  O OD1 . ASN A 1 60  ? -22.87698 6.57997   15.33665 1.000 38.64433 ? 97  ASN A OD1 1 
ATOM   499  N ND2 . ASN A 1 60  ? -24.91097 7.47711   15.66318 1.000 22.31602 ? 97  ASN A ND2 1 
ATOM   500  N N   . ASN A 1 61  ? -24.83475 2.57799   18.61198 1.000 16.66276 ? 98  ASN A N   1 
ATOM   501  C CA  . ASN A 1 61  ? -24.46791 1.69988   19.71526 1.000 18.84162 ? 98  ASN A CA  1 
ATOM   502  C C   . ASN A 1 61  ? -23.32555 0.76315   19.34760 1.000 16.60147 ? 98  ASN A C   1 
ATOM   503  O O   . ASN A 1 61  ? -22.62269 0.28062   20.24065 1.000 19.49751 ? 98  ASN A O   1 
ATOM   504  C CB  . ASN A 1 61  ? -25.68882 0.90502   20.17694 1.000 14.81597 ? 98  ASN A CB  1 
ATOM   505  C CG  . ASN A 1 61  ? -26.76503 1.79618   20.76596 1.000 22.98436 ? 98  ASN A CG  1 
ATOM   506  O OD1 . ASN A 1 61  ? -26.50140 2.59367   21.66702 1.000 27.89608 ? 98  ASN A OD1 1 
ATOM   507  N ND2 . ASN A 1 61  ? -27.97720 1.68759   20.23992 1.000 20.64839 ? 98  ASN A ND2 1 
ATOM   508  N N   . LEU A 1 62  ? -23.13333 0.50179   18.05951 1.000 21.49320 ? 99  LEU A N   1 
ATOM   509  C CA  . LEU A 1 62  ? -21.99440 -0.22727  17.51829 1.000 18.71739 ? 99  LEU A CA  1 
ATOM   510  C C   . LEU A 1 62  ? -21.71792 0.36159   16.13588 1.000 16.88184 ? 99  LEU A C   1 
ATOM   511  O O   . LEU A 1 62  ? -21.85347 -0.29065  15.10548 1.000 20.30563 ? 99  LEU A O   1 
ATOM   512  C CB  . LEU A 1 62  ? -22.27424 -1.72771  17.46114 1.000 9.51527  ? 99  LEU A CB  1 
ATOM   513  C CG  . LEU A 1 62  ? -21.08903 -2.64320  17.12991 1.000 19.14216 ? 99  LEU A CG  1 
ATOM   514  C CD1 . LEU A 1 62  ? -20.30895 -3.00216  18.38334 1.000 16.18481 ? 99  LEU A CD1 1 
ATOM   515  C CD2 . LEU A 1 62  ? -21.54443 -3.89882  16.40485 1.000 15.47324 ? 99  LEU A CD2 1 
ATOM   516  N N   . GLY A 1 63  ? -21.35026 1.63928   16.10221 1.000 16.98856 ? 100 GLY A N   1 
ATOM   517  C CA  . GLY A 1 63  ? -21.32377 2.37050   14.85271 1.000 23.78766 ? 100 GLY A CA  1 
ATOM   518  C C   . GLY A 1 63  ? -19.98486 2.95850   14.46287 1.000 24.43758 ? 100 GLY A C   1 
ATOM   519  O O   . GLY A 1 63  ? -18.92994 2.48115   14.89419 1.000 18.70439 ? 100 GLY A O   1 
ATOM   520  N N   . SER A 1 64  ? -20.03198 4.02111   13.65322 1.000 15.71516 ? 101 SER A N   1 
ATOM   521  C CA  . SER A 1 64  ? -18.84181 4.53307   12.98038 1.000 37.79821 ? 101 SER A CA  1 
ATOM   522  C C   . SER A 1 64  ? -17.78418 5.05727   13.94386 1.000 28.15176 ? 101 SER A C   1 
ATOM   523  O O   . SER A 1 64  ? -16.62236 5.19911   13.54758 1.000 23.92705 ? 101 SER A O   1 
ATOM   524  C CB  . SER A 1 64  ? -19.23772 5.64137   12.00646 1.000 24.10965 ? 101 SER A CB  1 
ATOM   525  O OG  . SER A 1 64  ? -19.73377 6.76515   12.70919 1.000 22.93840 ? 101 SER A OG  1 
ATOM   526  N N   . VAL A 1 65  ? -18.15490 5.36136   15.18937 1.000 23.59807 ? 102 VAL A N   1 
ATOM   527  C CA  . VAL A 1 65  ? -17.17305 5.84864   16.15331 1.000 19.76846 ? 102 VAL A CA  1 
ATOM   528  C C   . VAL A 1 65  ? -16.11870 4.78500   16.42603 1.000 28.02365 ? 102 VAL A C   1 
ATOM   529  O O   . VAL A 1 65  ? -14.95895 5.10595   16.71703 1.000 19.24948 ? 102 VAL A O   1 
ATOM   530  C CB  . VAL A 1 65  ? -17.88400 6.30547   17.44364 1.000 29.71662 ? 102 VAL A CB  1 
ATOM   531  C CG1 . VAL A 1 65  ? -16.87801 6.67464   18.51772 1.000 14.12978 ? 102 VAL A CG1 1 
ATOM   532  C CG2 . VAL A 1 65  ? -18.79345 7.49002   17.14737 1.000 26.07141 ? 102 VAL A CG2 1 
ATOM   533  N N   . LEU A 1 66  ? -16.49063 3.50680   16.30976 1.000 22.80251 ? 103 LEU A N   1 
ATOM   534  C CA  . LEU A 1 66  ? -15.52351 2.42583   16.45610 1.000 23.26030 ? 103 LEU A CA  1 
ATOM   535  C C   . LEU A 1 66  ? -14.37499 2.54421   15.46473 1.000 22.39594 ? 103 LEU A C   1 
ATOM   536  O O   . LEU A 1 66  ? -13.28470 2.02293   15.72657 1.000 15.17625 ? 103 LEU A O   1 
ATOM   537  C CB  . LEU A 1 66  ? -16.22000 1.07486   16.28964 1.000 17.09926 ? 103 LEU A CB  1 
ATOM   538  C CG  . LEU A 1 66  ? -17.21379 0.71528   17.39464 1.000 21.66697 ? 103 LEU A CG  1 
ATOM   539  C CD1 . LEU A 1 66  ? -17.93240 -0.58115  17.06534 1.000 18.34229 ? 103 LEU A CD1 1 
ATOM   540  C CD2 . LEU A 1 66  ? -16.49132 0.60942   18.72533 1.000 20.51780 ? 103 LEU A CD2 1 
ATOM   541  N N   . TYR A 1 67  ? -14.59315 3.21581   14.33669 1.000 20.23340 ? 104 TYR A N   1 
ATOM   542  C CA  . TYR A 1 67  ? -13.53508 3.48620   13.37492 1.000 24.88413 ? 104 TYR A CA  1 
ATOM   543  C C   . TYR A 1 67  ? -12.93225 4.87458   13.54752 1.000 19.26979 ? 104 TYR A C   1 
ATOM   544  O O   . TYR A 1 67  ? -11.71389 5.00420   13.69063 1.000 22.20933 ? 104 TYR A O   1 
ATOM   545  C CB  . TYR A 1 67  ? -14.06343 3.32262   11.94548 1.000 16.76242 ? 104 TYR A CB  1 
ATOM   546  C CG  . TYR A 1 67  ? -13.03420 3.65008   10.88983 1.000 24.97642 ? 104 TYR A CG  1 
ATOM   547  C CD1 . TYR A 1 67  ? -11.85236 2.92431   10.79708 1.000 22.82577 ? 104 TYR A CD1 1 
ATOM   548  C CD2 . TYR A 1 67  ? -13.24085 4.68484   9.98786  1.000 25.53743 ? 104 TYR A CD2 1 
ATOM   549  C CE1 . TYR A 1 67  ? -10.90386 3.22154   9.83507  1.000 24.36413 ? 104 TYR A CE1 1 
ATOM   550  C CE2 . TYR A 1 67  ? -12.30066 4.98758   9.01899  1.000 23.18079 ? 104 TYR A CE2 1 
ATOM   551  C CZ  . TYR A 1 67  ? -11.13489 4.25359   8.94760  1.000 38.83437 ? 104 TYR A CZ  1 
ATOM   552  O OH  . TYR A 1 67  ? -10.19893 4.55360   7.98486  1.000 27.47912 ? 104 TYR A OH  1 
ATOM   553  N N   . THR A 1 68  ? -13.76451 5.91998   13.54640 1.000 18.13677 ? 105 THR A N   1 
ATOM   554  C CA  . THR A 1 68  ? -13.24138 7.28187   13.56970 1.000 24.05895 ? 105 THR A CA  1 
ATOM   555  C C   . THR A 1 68  ? -12.59389 7.63875   14.90249 1.000 22.82713 ? 105 THR A C   1 
ATOM   556  O O   . THR A 1 68  ? -11.76427 8.55212   14.94419 1.000 31.20865 ? 105 THR A O   1 
ATOM   557  C CB  . THR A 1 68  ? -14.35043 8.28530   13.23275 1.000 25.50726 ? 105 THR A CB  1 
ATOM   558  O OG1 . THR A 1 68  ? -15.41102 8.18788   14.19203 1.000 19.57094 ? 105 THR A OG1 1 
ATOM   559  C CG2 . THR A 1 68  ? -14.90732 8.00971   11.84283 1.000 17.35461 ? 105 THR A CG2 1 
ATOM   560  N N   . THR A 1 69  ? -12.94119 6.94155   15.98490 1.000 29.54591 ? 106 THR A N   1 
ATOM   561  C CA  . THR A 1 69  ? -12.29288 7.13213   17.27774 1.000 22.20721 ? 106 THR A CA  1 
ATOM   562  C C   . THR A 1 69  ? -11.39097 5.95954   17.64172 1.000 29.88824 ? 106 THR A C   1 
ATOM   563  O O   . THR A 1 69  ? -10.18664 6.14083   17.84256 1.000 21.14847 ? 106 THR A O   1 
ATOM   564  C CB  . THR A 1 69  ? -13.34167 7.35005   18.37986 1.000 28.70727 ? 106 THR A CB  1 
ATOM   565  O OG1 . THR A 1 69  ? -13.98661 8.61711   18.19608 1.000 25.41237 ? 106 THR A OG1 1 
ATOM   566  C CG2 . THR A 1 69  ? -12.69200 7.30638   19.75650 1.000 18.37161 ? 106 THR A CG2 1 
ATOM   567  N N   . ASN A 1 70  ? -11.94374 4.74848   17.72510 1.000 29.46298 ? 107 ASN A N   1 
ATOM   568  C CA  . ASN A 1 70  ? -11.19524 3.59365   18.20656 1.000 26.03884 ? 107 ASN A CA  1 
ATOM   569  C C   . ASN A 1 70  ? -10.29359 2.97181   17.14560 1.000 27.30988 ? 107 ASN A C   1 
ATOM   570  O O   . ASN A 1 70  ? -9.41992  2.16894   17.49368 1.000 23.76535 ? 107 ASN A O   1 
ATOM   571  C CB  . ASN A 1 70  ? -12.16857 2.54695   18.75197 1.000 18.25982 ? 107 ASN A CB  1 
ATOM   572  C CG  . ASN A 1 70  ? -13.13459 3.13212   19.76678 1.000 26.09540 ? 107 ASN A CG  1 
ATOM   573  O OD1 . ASN A 1 70  ? -14.33669 3.22573   19.51606 1.000 26.80714 ? 107 ASN A OD1 1 
ATOM   574  N ND2 . ASN A 1 70  ? -12.60960 3.53969   20.91693 1.000 24.26812 ? 107 ASN A ND2 1 
ATOM   575  N N   . GLY A 1 71  ? -10.48139 3.31262   15.87302 1.000 19.51093 ? 108 GLY A N   1 
ATOM   576  C CA  . GLY A 1 71  ? -9.56714  2.87615   14.83749 1.000 18.15463 ? 108 GLY A CA  1 
ATOM   577  C C   . GLY A 1 71  ? -9.73622  1.45291   14.36175 1.000 22.93000 ? 108 GLY A C   1 
ATOM   578  O O   . GLY A 1 71  ? -8.79474  0.88903   13.79623 1.000 21.09263 ? 108 GLY A O   1 
ATOM   579  N N   . TYR A 1 72  ? -10.90364 0.84817   14.56559 1.000 17.55999 ? 109 TYR A N   1 
ATOM   580  C CA  . TYR A 1 72  ? -11.16057 -0.50991  14.08863 1.000 17.19492 ? 109 TYR A CA  1 
ATOM   581  C C   . TYR A 1 72  ? -11.66481 -0.42759  12.65313 1.000 24.17109 ? 109 TYR A C   1 
ATOM   582  O O   . TYR A 1 72  ? -12.82451 -0.08732  12.40409 1.000 18.96836 ? 109 TYR A O   1 
ATOM   583  C CB  . TYR A 1 72  ? -12.14830 -1.22837  14.99994 1.000 18.58365 ? 109 TYR A CB  1 
ATOM   584  C CG  . TYR A 1 72  ? -11.56642 -1.54152  16.35618 1.000 21.94277 ? 109 TYR A CG  1 
ATOM   585  C CD1 . TYR A 1 72  ? -10.51076 -2.43544  16.48668 1.000 12.52521 ? 109 TYR A CD1 1 
ATOM   586  C CD2 . TYR A 1 72  ? -12.06443 -0.94139  17.50427 1.000 15.65492 ? 109 TYR A CD2 1 
ATOM   587  C CE1 . TYR A 1 72  ? -9.96808  -2.72190  17.72197 1.000 17.54174 ? 109 TYR A CE1 1 
ATOM   588  C CE2 . TYR A 1 72  ? -11.52861 -1.22392  18.74582 1.000 13.40486 ? 109 TYR A CE2 1 
ATOM   589  C CZ  . TYR A 1 72  ? -10.48120 -2.11357  18.84785 1.000 15.69064 ? 109 TYR A CZ  1 
ATOM   590  O OH  . TYR A 1 72  ? -9.94285  -2.39730  20.07881 1.000 21.38523 ? 109 TYR A OH  1 
ATOM   591  N N   . ASP A 1 73  ? -10.78004 -0.74101  11.70314 1.000 19.11503 ? 110 ASP A N   1 
ATOM   592  C CA  . ASP A 1 73  ? -11.13422 -0.69926  10.28893 1.000 18.16242 ? 110 ASP A CA  1 
ATOM   593  C C   . ASP A 1 73  ? -12.25757 -1.66691  9.94551  1.000 19.54788 ? 110 ASP A C   1 
ATOM   594  O O   . ASP A 1 73  ? -12.93936 -1.47528  8.93328  1.000 15.86078 ? 110 ASP A O   1 
ATOM   595  C CB  . ASP A 1 73  ? -9.89990  -1.01039  9.44277  1.000 12.80495 ? 110 ASP A CB  1 
ATOM   596  C CG  . ASP A 1 73  ? -8.72398  -0.11696  9.78468  1.000 29.28207 ? 110 ASP A CG  1 
ATOM   597  O OD1 . ASP A 1 73  ? -8.56740  0.94291   9.14315  1.000 29.71283 ? 110 ASP A OD1 1 
ATOM   598  O OD2 . ASP A 1 73  ? -7.97094  -0.46034  10.71916 1.000 24.72782 ? 110 ASP A OD2 1 
ATOM   599  N N   . GLY A 1 74  ? -12.46009 -2.69942  10.75751 1.000 11.26710 ? 111 GLY A N   1 
ATOM   600  C CA  . GLY A 1 74  ? -13.51204 -3.66061  10.51357 1.000 18.16418 ? 111 GLY A CA  1 
ATOM   601  C C   . GLY A 1 74  ? -14.20841 -4.08650  11.78810 1.000 27.76605 ? 111 GLY A C   1 
ATOM   602  O O   . GLY A 1 74  ? -13.55833 -4.52546  12.74207 1.000 19.22215 ? 111 GLY A O   1 
ATOM   603  N N   . VAL A 1 75  ? -15.53099 -3.94130  11.81936 1.000 13.74651 ? 112 VAL A N   1 
ATOM   604  C CA  . VAL A 1 75  ? -16.36375 -4.39443  12.92670 1.000 12.54506 ? 112 VAL A CA  1 
ATOM   605  C C   . VAL A 1 75  ? -17.40908 -5.34150  12.35803 1.000 15.09340 ? 112 VAL A C   1 
ATOM   606  O O   . VAL A 1 75  ? -18.12247 -4.98861  11.41154 1.000 20.28238 ? 112 VAL A O   1 
ATOM   607  C CB  . VAL A 1 75  ? -17.02915 -3.21734  13.66312 1.000 18.53120 ? 112 VAL A CB  1 
ATOM   608  C CG1 . VAL A 1 75  ? -17.99512 -3.73236  14.72415 1.000 13.43610 ? 112 VAL A CG1 1 
ATOM   609  C CG2 . VAL A 1 75  ? -15.97201 -2.31619  14.28548 1.000 9.64147  ? 112 VAL A CG2 1 
ATOM   610  N N   . PHE A 1 76  ? -17.49565 -6.54104  12.92612 1.000 12.19271 ? 113 PHE A N   1 
ATOM   611  C CA  . PHE A 1 76  ? -18.32716 -7.58735  12.35475 1.000 10.75192 ? 113 PHE A CA  1 
ATOM   612  C C   . PHE A 1 76  ? -19.10607 -8.30307  13.44509 1.000 17.48752 ? 113 PHE A C   1 
ATOM   613  O O   . PHE A 1 76  ? -18.65672 -8.40926  14.58961 1.000 13.41014 ? 113 PHE A O   1 
ATOM   614  C CB  . PHE A 1 76  ? -17.49420 -8.62269  11.58214 1.000 22.91549 ? 113 PHE A CB  1 
ATOM   615  C CG  . PHE A 1 76  ? -16.64921 -8.03584  10.48649 1.000 24.72429 ? 113 PHE A CG  1 
ATOM   616  C CD1 . PHE A 1 76  ? -15.40120 -7.50315  10.76513 1.000 16.28923 ? 113 PHE A CD1 1 
ATOM   617  C CD2 . PHE A 1 76  ? -17.09619 -8.03469  9.17460  1.000 23.91159 ? 113 PHE A CD2 1 
ATOM   618  C CE1 . PHE A 1 76  ? -14.62027 -6.96964  9.75808  1.000 23.78255 ? 113 PHE A CE1 1 
ATOM   619  C CE2 . PHE A 1 76  ? -16.31950 -7.50376  8.16334  1.000 14.96971 ? 113 PHE A CE2 1 
ATOM   620  C CZ  . PHE A 1 76  ? -15.08082 -6.96999  8.45556  1.000 18.94956 ? 113 PHE A CZ  1 
ATOM   621  N N   . VAL A 1 77  ? -20.28319 -8.79510  13.06704 1.000 16.99533 ? 114 VAL A N   1 
ATOM   622  C CA  . VAL A 1 77  ? -21.03322 -9.77358  13.84258 1.000 12.59685 ? 114 VAL A CA  1 
ATOM   623  C C   . VAL A 1 77  ? -21.21866 -11.00480 12.96623 1.000 13.40988 ? 114 VAL A C   1 
ATOM   624  O O   . VAL A 1 77  ? -21.68161 -10.89447 11.82491 1.000 16.37509 ? 114 VAL A O   1 
ATOM   625  C CB  . VAL A 1 77  ? -22.39042 -9.21954  14.31244 1.000 17.80769 ? 114 VAL A CB  1 
ATOM   626  C CG1 . VAL A 1 77  ? -23.20953 -10.31909 14.97181 1.000 14.12583 ? 114 VAL A CG1 1 
ATOM   627  C CG2 . VAL A 1 77  ? -22.18467 -8.06376  15.27021 1.000 12.48816 ? 114 VAL A CG2 1 
ATOM   628  N N   . ILE A 1 78  ? -20.84055 -12.17195 13.48981 1.000 13.55455 ? 115 ILE A N   1 
ATOM   629  C CA  . ILE A 1 78  ? -20.91649 -13.41968 12.74340 1.000 22.34104 ? 115 ILE A CA  1 
ATOM   630  C C   . ILE A 1 78  ? -21.64357 -14.46190 13.58172 1.000 19.99960 ? 115 ILE A C   1 
ATOM   631  O O   . ILE A 1 78  ? -21.69358 -14.38444 14.81121 1.000 16.38127 ? 115 ILE A O   1 
ATOM   632  C CB  . ILE A 1 78  ? -19.52282 -13.95085 12.33174 1.000 11.77149 ? 115 ILE A CB  1 
ATOM   633  C CG1 . ILE A 1 78  ? -18.72143 -14.36636 13.56570 1.000 8.18872  ? 115 ILE A CG1 1 
ATOM   634  C CG2 . ILE A 1 78  ? -18.75914 -12.91050 11.51991 1.000 7.71361  ? 115 ILE A CG2 1 
ATOM   635  C CD1 . ILE A 1 78  ? -17.38041 -14.99346 13.23735 1.000 12.02880 ? 115 ILE A CD1 1 
ATOM   636  N N   . ASP A 1 79  ? -22.21450 -15.44492 12.89073 1.000 14.48138 ? 116 ASP A N   1 
ATOM   637  C CA  . ASP A 1 79  ? -22.81282 -16.60949 13.53050 1.000 23.82088 ? 116 ASP A CA  1 
ATOM   638  C C   . ASP A 1 79  ? -22.58335 -17.81418 12.62128 1.000 32.66250 ? 116 ASP A C   1 
ATOM   639  O O   . ASP A 1 79  ? -21.78116 -17.75878 11.68380 1.000 27.52437 ? 116 ASP A O   1 
ATOM   640  C CB  . ASP A 1 79  ? -24.29655 -16.36303 13.85402 1.000 24.47896 ? 116 ASP A CB  1 
ATOM   641  C CG  . ASP A 1 79  ? -25.16118 -16.14668 12.61196 1.000 26.18478 ? 116 ASP A CG  1 
ATOM   642  O OD1 . ASP A 1 79  ? -24.67799 -16.31464 11.47299 1.000 35.78740 ? 116 ASP A OD1 1 
ATOM   643  O OD2 . ASP A 1 79  ? -26.34815 -15.80037 12.78343 1.000 41.85348 ? 116 ASP A OD2 1 
ATOM   644  N N   . ASP A 1 80  ? -23.30408 -18.90618 12.89366 1.000 28.72860 ? 117 ASP A N   1 
ATOM   645  C CA  . ASP A 1 80  ? -23.11654 -20.14109 12.13754 1.000 30.63479 ? 117 ASP A CA  1 
ATOM   646  C C   . ASP A 1 80  ? -23.44283 -19.98245 10.65817 1.000 25.95170 ? 117 ASP A C   1 
ATOM   647  O O   . ASP A 1 80  ? -22.95341 -20.76960 9.84206  1.000 33.21446 ? 117 ASP A O   1 
ATOM   648  C CB  . ASP A 1 80  ? -23.97264 -21.25870 12.73538 1.000 22.50362 ? 117 ASP A CB  1 
ATOM   649  C CG  . ASP A 1 80  ? -23.48052 -21.70506 14.09691 1.000 29.92076 ? 117 ASP A CG  1 
ATOM   650  O OD1 . ASP A 1 80  ? -22.27892 -22.02091 14.22246 1.000 48.30000 ? 117 ASP A OD1 1 
ATOM   651  O OD2 . ASP A 1 80  ? -24.29380 -21.73353 15.04400 1.000 37.71871 ? 117 ASP A OD2 1 
ATOM   652  N N   . ARG A 1 81  ? -24.25405 -18.99234 10.29247 1.000 35.47940 ? 118 ARG A N   1 
ATOM   653  C CA  . ARG A 1 81  ? -24.61173 -18.77036 8.89866  1.000 28.86526 ? 118 ARG A CA  1 
ATOM   654  C C   . ARG A 1 81  ? -23.65979 -17.82524 8.17705  1.000 35.23610 ? 118 ARG A C   1 
ATOM   655  O O   . ARG A 1 81  ? -23.79689 -17.64477 6.96265  1.000 45.05054 ? 118 ARG A O   1 
ATOM   656  C CB  . ARG A 1 81  ? -26.04285 -18.23123 8.80326  1.000 41.65459 ? 118 ARG A CB  1 
ATOM   657  C CG  . ARG A 1 81  ? -27.11210 -19.29608 9.00042  1.000 54.07169 ? 118 ARG A CG  1 
ATOM   658  C CD  . ARG A 1 81  ? -28.36608 -18.71928 9.63688  1.000 60.29251 ? 118 ARG A CD  1 
ATOM   659  N NE  . ARG A 1 81  ? -28.11228 -18.24334 10.99432 1.000 71.00885 ? 118 ARG A NE  1 
ATOM   660  C CZ  . ARG A 1 81  ? -28.10391 -19.02443 12.07040 1.000 69.84069 ? 118 ARG A CZ  1 
ATOM   661  N NH1 . ARG A 1 81  ? -28.33431 -20.32515 11.95012 1.000 81.87358 ? 118 ARG A NH1 1 
ATOM   662  N NH2 . ARG A 1 81  ? -27.86206 -18.50682 13.26748 1.000 62.69574 ? 118 ARG A NH2 1 
ATOM   663  N N   . GLY A 1 82  ? -22.70255 -17.22306 8.88487  1.000 29.20510 ? 119 GLY A N   1 
ATOM   664  C CA  . GLY A 1 82  ? -21.73706 -16.33124 8.27836  1.000 17.71405 ? 119 GLY A CA  1 
ATOM   665  C C   . GLY A 1 82  ? -21.80008 -14.94033 8.88730  1.000 17.36251 ? 119 GLY A C   1 
ATOM   666  O O   . GLY A 1 82  ? -22.16422 -14.76956 10.05588 1.000 24.19569 ? 119 GLY A O   1 
ATOM   667  N N   . THR A 1 83  ? -21.44641 -13.94944 8.07453  1.000 16.32277 ? 120 THR A N   1 
ATOM   668  C CA  . THR A 1 83  ? -21.41531 -12.56353 8.52350  1.000 22.11718 ? 120 THR A CA  1 
ATOM   669  C C   . THR A 1 83  ? -22.82910 -11.99622 8.55884  1.000 25.56093 ? 120 THR A C   1 
ATOM   670  O O   . THR A 1 83  ? -23.53963 -12.01261 7.54785  1.000 28.70084 ? 120 THR A O   1 
ATOM   671  C CB  . THR A 1 83  ? -20.52269 -11.73051 7.60900  1.000 16.97816 ? 120 THR A CB  1 
ATOM   672  O OG1 . THR A 1 83  ? -19.17155 -12.19487 7.71721  1.000 22.08305 ? 120 THR A OG1 1 
ATOM   673  C CG2 . THR A 1 83  ? -20.58504 -10.25995 7.99459  1.000 17.45502 ? 120 THR A CG2 1 
ATOM   674  N N   . ARG A 1 84  ? -23.23419 -11.49493 9.72504  1.000 24.78456 ? 121 ARG A N   1 
ATOM   675  C CA  . ARG A 1 84  ? -24.54891 -10.90134 9.90706  1.000 20.76292 ? 121 ARG A CA  1 
ATOM   676  C C   . ARG A 1 84  ? -24.51333 -9.38327  9.98386  1.000 22.30721 ? 121 ARG A C   1 
ATOM   677  O O   . ARG A 1 84  ? -25.57424 -8.75151  9.93305  1.000 22.23634 ? 121 ARG A O   1 
ATOM   678  C CB  . ARG A 1 84  ? -25.20683 -11.45895 11.17760 1.000 20.81821 ? 121 ARG A CB  1 
ATOM   679  C CG  . ARG A 1 84  ? -25.30093 -12.97544 11.21217 1.000 31.81692 ? 121 ARG A CG  1 
ATOM   680  C CD  . ARG A 1 84  ? -26.10721 -13.50752 10.03398 1.000 24.58156 ? 121 ARG A CD  1 
ATOM   681  N NE  . ARG A 1 84  ? -27.48483 -13.02772 10.05691 1.000 36.22886 ? 121 ARG A NE  1 
ATOM   682  C CZ  . ARG A 1 84  ? -28.49949 -13.69602 10.59690 1.000 66.62378 ? 121 ARG A CZ  1 
ATOM   683  N NH1 . ARG A 1 84  ? -28.29402 -14.88099 11.15757 1.000 54.56868 ? 121 ARG A NH1 1 
ATOM   684  N NH2 . ARG A 1 84  ? -29.72148 -13.18148 10.57347 1.000 58.81308 ? 121 ARG A NH2 1 
ATOM   685  N N   . TYR A 1 85  ? -23.32879 -8.78712  10.09675 1.000 16.72873 ? 122 TYR A N   1 
ATOM   686  C CA  . TYR A 1 85  ? -23.18521 -7.34353  10.22638 1.000 16.49217 ? 122 TYR A CA  1 
ATOM   687  C C   . TYR A 1 85  ? -21.73427 -7.00300  9.93618  1.000 20.39883 ? 122 TYR A C   1 
ATOM   688  O O   . TYR A 1 85  ? -20.82991 -7.64931  10.47144 1.000 18.03320 ? 122 TYR A O   1 
ATOM   689  C CB  . TYR A 1 85  ? -23.58781 -6.87144  11.63137 1.000 13.72315 ? 122 TYR A CB  1 
ATOM   690  C CG  . TYR A 1 85  ? -23.42985 -5.38533  11.87956 1.000 23.22301 ? 122 TYR A CG  1 
ATOM   691  C CD1 . TYR A 1 85  ? -24.44909 -4.49606  11.56185 1.000 17.62377 ? 122 TYR A CD1 1 
ATOM   692  C CD2 . TYR A 1 85  ? -22.26901 -4.87361  12.45039 1.000 23.05678 ? 122 TYR A CD2 1 
ATOM   693  C CE1 . TYR A 1 85  ? -24.31386 -3.13853  11.79486 1.000 15.25528 ? 122 TYR A CE1 1 
ATOM   694  C CE2 . TYR A 1 85  ? -22.12391 -3.51481  12.68534 1.000 14.13517 ? 122 TYR A CE2 1 
ATOM   695  C CZ  . TYR A 1 85  ? -23.15101 -2.65242  12.35693 1.000 22.76500 ? 122 TYR A CZ  1 
ATOM   696  O OH  . TYR A 1 85  ? -23.01682 -1.29948  12.58979 1.000 15.13020 ? 122 TYR A OH  1 
ATOM   697  N N   . ALA A 1 86  ? -21.51324 -6.00765  9.08442  1.000 26.56437 ? 123 ALA A N   1 
ATOM   698  C CA  . ALA A 1 86  ? -20.16253 -5.61923  8.70697  1.000 18.40776 ? 123 ALA A CA  1 
ATOM   699  C C   . ALA A 1 86  ? -20.09710 -4.10899  8.58265  1.000 16.14352 ? 123 ALA A C   1 
ATOM   700  O O   . ALA A 1 86  ? -20.95964 -3.49630  7.94691  1.000 20.53161 ? 123 ALA A O   1 
ATOM   701  C CB  . ALA A 1 86  ? -19.73488 -6.27714  7.38895  1.000 14.83674 ? 123 ALA A CB  1 
ATOM   702  N N   . MET A 1 87  ? -19.07840 -3.51641  9.19598  1.000 21.03598 ? 124 MET A N   1 
ATOM   703  C CA  . MET A 1 87  ? -18.82058 -2.08666  9.08983  1.000 16.22116 ? 124 MET A CA  1 
ATOM   704  C C   . MET A 1 87  ? -17.34863 -1.90951  8.75373  1.000 23.62950 ? 124 MET A C   1 
ATOM   705  O O   . MET A 1 87  ? -16.48193 -2.11148  9.61112  1.000 25.21926 ? 124 MET A O   1 
ATOM   706  C CB  . MET A 1 87  ? -19.18135 -1.35742  10.38016 1.000 18.68380 ? 124 MET A CB  1 
ATOM   707  C CG  . MET A 1 87  ? -19.32929 0.14160   10.21293 1.000 15.06484 ? 124 MET A CG  1 
ATOM   708  S SD  . MET A 1 87  ? -19.25349 1.00629   11.78710 1.000 27.24681 ? 124 MET A SD  1 
ATOM   709  C CE  . MET A 1 87  ? -19.73455 -0.30561  12.89754 1.000 32.63637 ? 124 MET A CE  1 
ATOM   710  N N   . LEU A 1 88  ? -17.06943 -1.55111  7.50723  1.000 18.88109 ? 125 LEU A N   1 
ATOM   711  C CA  . LEU A 1 88  ? -15.70952 -1.35431  7.03141  1.000 15.03837 ? 125 LEU A CA  1 
ATOM   712  C C   . LEU A 1 88  ? -15.44375 0.14059   6.91862  1.000 21.50729 ? 125 LEU A C   1 
ATOM   713  O O   . LEU A 1 88  ? -16.13072 0.84185   6.16703  1.000 32.81947 ? 125 LEU A O   1 
ATOM   714  C CB  . LEU A 1 88  ? -15.50124 -2.05682  5.69021  1.000 21.25519 ? 125 LEU A CB  1 
ATOM   715  C CG  . LEU A 1 88  ? -15.46797 -3.58341  5.79529  1.000 28.19393 ? 125 LEU A CG  1 
ATOM   716  C CD1 . LEU A 1 88  ? -15.46373 -4.23357  4.42429  1.000 28.21558 ? 125 LEU A CD1 1 
ATOM   717  C CD2 . LEU A 1 88  ? -14.25443 -4.02315  6.60066  1.000 23.06258 ? 125 LEU A CD2 1 
ATOM   718  N N   . GLU A 1 89  ? -14.46046 0.62251   7.67941  1.000 15.14187 ? 126 GLU A N   1 
ATOM   719  C CA  . GLU A 1 89  ? -14.10091 2.04012   7.70868  1.000 29.19682 ? 126 GLU A CA  1 
ATOM   720  C C   . GLU A 1 89  ? -15.30230 2.90664   8.08811  1.000 25.51363 ? 126 GLU A C   1 
ATOM   721  O O   . GLU A 1 89  ? -15.57619 3.93910   7.47338  1.000 30.72458 ? 126 GLU A O   1 
ATOM   722  C CB  . GLU A 1 89  ? -13.49599 2.48128   6.37290  1.000 24.72872 ? 126 GLU A CB  1 
ATOM   723  C CG  . GLU A 1 89  ? -12.12313 1.88513   6.09647  1.000 31.39905 ? 126 GLU A CG  1 
ATOM   724  C CD  . GLU A 1 89  ? -11.59810 2.23537   4.71760  1.000 39.31160 ? 126 GLU A CD  1 
ATOM   725  O OE1 . GLU A 1 89  ? -11.11707 1.32264   4.01415  1.000 38.06496 ? 126 GLU A OE1 1 
ATOM   726  O OE2 . GLU A 1 89  ? -11.67070 3.42192   4.33595  1.000 33.58831 ? 126 GLU A OE2 1 
ATOM   727  N N   . GLY A 1 90  ? -16.02416 2.47157   9.11894  1.000 20.96293 ? 127 GLY A N   1 
ATOM   728  C CA  . GLY A 1 90  ? -17.12575 3.25118   9.64641  1.000 31.08073 ? 127 GLY A CA  1 
ATOM   729  C C   . GLY A 1 90  ? -18.34941 3.33411   8.76409  1.000 22.43054 ? 127 GLY A C   1 
ATOM   730  O O   . GLY A 1 90  ? -19.20498 4.19136   8.99487  1.000 22.46895 ? 127 GLY A O   1 
ATOM   731  N N   . GLU A 1 91  ? -18.46106 2.47017   7.75732  1.000 23.68614 ? 128 GLU A N   1 
ATOM   732  C CA  . GLU A 1 91  ? -19.61100 2.44623   6.86496  1.000 15.17137 ? 128 GLU A CA  1 
ATOM   733  C C   . GLU A 1 91  ? -20.15753 1.03036   6.77934  1.000 21.53878 ? 128 GLU A C   1 
ATOM   734  O O   . GLU A 1 91  ? -19.39111 0.06274   6.74055  1.000 21.97715 ? 128 GLU A O   1 
ATOM   735  C CB  . GLU A 1 91  ? -19.24596 2.94454   5.45867  1.000 18.25070 ? 128 GLU A CB  1 
ATOM   736  C CG  . GLU A 1 91  ? -18.75611 4.38381   5.40903  1.000 47.39421 ? 128 GLU A CG  1 
ATOM   737  C CD  . GLU A 1 91  ? -18.48046 4.85865   3.99320  1.000 63.72379 ? 128 GLU A CD  1 
ATOM   738  O OE1 . GLU A 1 91  ? -18.90541 4.17208   3.03957  1.000 70.03073 ? 128 GLU A OE1 1 
ATOM   739  O OE2 . GLU A 1 91  ? -17.83685 5.91767   3.83366  1.000 64.93524 ? 128 GLU A OE2 1 
ATOM   740  N N   . LEU A 1 92  ? -21.48410 0.91539   6.74988  1.000 19.31595 ? 129 LEU A N   1 
ATOM   741  C CA  . LEU A 1 92  ? -22.11361 -0.38993  6.60814  1.000 20.98759 ? 129 LEU A CA  1 
ATOM   742  C C   . LEU A 1 92  ? -21.69304 -1.03983  5.29721  1.000 24.30048 ? 129 LEU A C   1 
ATOM   743  O O   . LEU A 1 92  ? -21.51731 -0.36781  4.27808  1.000 22.90344 ? 129 LEU A O   1 
ATOM   744  C CB  . LEU A 1 92  ? -23.63515 -0.26009  6.66820  1.000 17.76444 ? 129 LEU A CB  1 
ATOM   745  C CG  . LEU A 1 92  ? -24.22881 0.11212   8.02658  1.000 22.59879 ? 129 LEU A CG  1 
ATOM   746  C CD1 . LEU A 1 92  ? -25.74058 0.19396   7.93912  1.000 20.27619 ? 129 LEU A CD1 1 
ATOM   747  C CD2 . LEU A 1 92  ? -23.80844 -0.89741  9.08066  1.000 19.07685 ? 129 LEU A CD2 1 
ATOM   748  N N   . SER A 1 93  ? -21.52835 -2.35870  5.32986  1.000 27.26789 ? 130 SER A N   1 
ATOM   749  C CA  . SER A 1 93  ? -21.04363 -3.10180  4.17986  1.000 18.27696 ? 130 SER A CA  1 
ATOM   750  C C   . SER A 1 93  ? -21.75447 -4.44315  4.10295  1.000 29.21815 ? 130 SER A C   1 
ATOM   751  O O   . SER A 1 93  ? -22.16281 -5.00810  5.12143  1.000 25.56146 ? 130 SER A O   1 
ATOM   752  C CB  . SER A 1 93  ? -19.52287 -3.31523  4.25274  1.000 27.10511 ? 130 SER A CB  1 
ATOM   753  O OG  . SER A 1 93  ? -19.06220 -4.10074  3.16721  1.000 32.92826 ? 130 SER A OG  1 
ATOM   754  N N   . GLU A 1 94  ? -21.90725 -4.94025  2.87823  1.000 28.20522 ? 131 GLU A N   1 
ATOM   755  C CA  . GLU A 1 94  ? -22.39615 -6.28985  2.63877  1.000 27.41457 ? 131 GLU A CA  1 
ATOM   756  C C   . GLU A 1 94  ? -21.26346 -7.29367  2.47920  1.000 20.11237 ? 131 GLU A C   1 
ATOM   757  O O   . GLU A 1 94  ? -21.52686 -8.47520  2.23469  1.000 29.13661 ? 131 GLU A O   1 
ATOM   758  C CB  . GLU A 1 94  ? -23.29082 -6.31853  1.39480  1.000 34.70223 ? 131 GLU A CB  1 
ATOM   759  C CG  . GLU A 1 94  ? -24.49062 -5.38277  1.46041  1.000 32.53702 ? 131 GLU A CG  1 
ATOM   760  C CD  . GLU A 1 94  ? -25.36336 -5.63581  2.67503  1.000 38.63646 ? 131 GLU A CD  1 
ATOM   761  O OE1 . GLU A 1 94  ? -25.22192 -4.90334  3.67759  1.000 56.79557 ? 131 GLU A OE1 1 
ATOM   762  O OE2 . GLU A 1 94  ? -26.18509 -6.57384  2.63110  1.000 32.00824 ? 131 GLU A OE2 1 
ATOM   763  N N   . ARG A 1 95  ? -20.01647 -6.85112  2.60785  1.000 22.63025 ? 132 ARG A N   1 
ATOM   764  C CA  . ARG A 1 95  ? -18.88197 -7.75232  2.47924  1.000 32.10948 ? 132 ARG A CA  1 
ATOM   765  C C   . ARG A 1 95  ? -18.75439 -8.62405  3.72188  1.000 29.95416 ? 132 ARG A C   1 
ATOM   766  O O   . ARG A 1 95  ? -18.86215 -8.14219  4.85264  1.000 32.35823 ? 132 ARG A O   1 
ATOM   767  C CB  . ARG A 1 95  ? -17.59964 -6.95343  2.26063  1.000 25.66632 ? 132 ARG A CB  1 
ATOM   768  C CG  . ARG A 1 95  ? -16.41923 -7.78568  1.81251  1.000 29.38400 ? 132 ARG A CG  1 
ATOM   769  C CD  . ARG A 1 95  ? -15.17420 -6.92996  1.71118  1.000 31.64648 ? 132 ARG A CD  1 
ATOM   770  N NE  . ARG A 1 95  ? -14.01849 -7.69769  1.26438  1.000 20.28453 ? 132 ARG A NE  1 
ATOM   771  C CZ  . ARG A 1 95  ? -12.76726 -7.26218  1.33932  1.000 33.55863 ? 132 ARG A CZ  1 
ATOM   772  N NH1 . ARG A 1 95  ? -12.51479 -6.06443  1.84993  1.000 26.90005 ? 132 ARG A NH1 1 
ATOM   773  N NH2 . ARG A 1 95  ? -11.76973 -8.02471  0.91050  1.000 30.53655 ? 132 ARG A NH2 1 
ATOM   774  N N   . SER A 1 96  ? -18.52790 -9.91606  3.50760  1.000 20.06864 ? 133 SER A N   1 
ATOM   775  C CA  . SER A 1 96  ? -18.42190 -10.84664 4.61846  1.000 26.19060 ? 133 SER A CA  1 
ATOM   776  C C   . SER A 1 96  ? -17.05218 -10.74252 5.28238  1.000 26.31224 ? 133 SER A C   1 
ATOM   777  O O   . SER A 1 96  ? -16.08538 -10.23467 4.70656  1.000 20.55616 ? 133 SER A O   1 
ATOM   778  C CB  . SER A 1 96  ? -18.65758 -12.28212 4.14873  1.000 21.34629 ? 133 SER A CB  1 
ATOM   779  O OG  . SER A 1 96  ? -17.54081 -12.76424 3.42129  1.000 20.40003 ? 133 SER A OG  1 
ATOM   780  N N   . LEU A 1 97  ? -16.98220 -11.23332 6.52134  1.000 17.02267 ? 134 LEU A N   1 
ATOM   781  C CA  . LEU A 1 97  ? -15.69733 -11.31431 7.20706  1.000 25.29336 ? 134 LEU A CA  1 
ATOM   782  C C   . LEU A 1 97  ? -14.76943 -12.30713 6.51702  1.000 20.81219 ? 134 LEU A C   1 
ATOM   783  O O   . LEU A 1 97  ? -13.55691 -12.07973 6.43519  1.000 21.96123 ? 134 LEU A O   1 
ATOM   784  C CB  . LEU A 1 97  ? -15.90738 -11.70425 8.67130  1.000 23.07571 ? 134 LEU A CB  1 
ATOM   785  C CG  . LEU A 1 97  ? -14.64102 -11.83142 9.52198  1.000 19.35286 ? 134 LEU A CG  1 
ATOM   786  C CD1 . LEU A 1 97  ? -13.93827 -10.48771 9.62173  1.000 26.59244 ? 134 LEU A CD1 1 
ATOM   787  C CD2 . LEU A 1 97  ? -14.95036 -12.38649 10.90835 1.000 11.70046 ? 134 LEU A CD2 1 
ATOM   788  N N   . ALA A 1 98  ? -15.32429 -13.40798 6.00337  1.000 14.80521 ? 135 ALA A N   1 
ATOM   789  C CA  . ALA A 1 98  ? -14.49439 -14.44414 5.39720  1.000 20.97271 ? 135 ALA A CA  1 
ATOM   790  C C   . ALA A 1 98  ? -13.78944 -13.93453 4.14664  1.000 22.70975 ? 135 ALA A C   1 
ATOM   791  O O   . ALA A 1 98  ? -12.63115 -14.28443 3.89272  1.000 24.65101 ? 135 ALA A O   1 
ATOM   792  C CB  . ALA A 1 98  ? -15.34448 -15.67216 5.07222  1.000 16.19186 ? 135 ALA A CB  1 
ATOM   793  N N   . ASP A 1 99  ? -14.46828 -13.10221 3.35491  1.000 20.73166 ? 136 ASP A N   1 
ATOM   794  C CA  . ASP A 1 99  ? -13.86712 -12.61068 2.12018  1.000 21.10036 ? 136 ASP A CA  1 
ATOM   795  C C   . ASP A 1 99  ? -12.71091 -11.65806 2.38687  1.000 26.74282 ? 136 ASP A C   1 
ATOM   796  O O   . ASP A 1 99  ? -11.79587 -11.55199 1.56280  1.000 20.46508 ? 136 ASP A O   1 
ATOM   797  C CB  . ASP A 1 99  ? -14.91636 -11.91464 1.26054  1.000 24.21725 ? 136 ASP A CB  1 
ATOM   798  C CG  . ASP A 1 99  ? -14.32920 -11.33033 -0.01082 1.000 25.57473 ? 136 ASP A CG  1 
ATOM   799  O OD1 . ASP A 1 99  ? -13.97271 -12.11313 -0.91582 1.000 22.87951 ? 136 ASP A OD1 1 
ATOM   800  O OD2 . ASP A 1 99  ? -14.22060 -10.08996 -0.10290 1.000 28.48475 ? 136 ASP A OD2 1 
ATOM   801  N N   . SER A 1 100 ? -12.73413 -10.95304 3.51180  1.000 19.51201 ? 137 SER A N   1 
ATOM   802  C CA  . SER A 1 100 ? -11.67944 -10.00405 3.83424  1.000 30.74125 ? 137 SER A CA  1 
ATOM   803  C C   . SER A 1 100 ? -10.55954 -10.61693 4.66356  1.000 24.64269 ? 137 SER A C   1 
ATOM   804  O O   . SER A 1 100 ? -9.63269  -9.89716  5.04921  1.000 21.29750 ? 137 SER A O   1 
ATOM   805  C CB  . SER A 1 100 ? -12.26701 -8.79851  4.57300  1.000 35.07137 ? 137 SER A CB  1 
ATOM   806  O OG  . SER A 1 100 ? -12.93917 -9.20227  5.75278  1.000 37.20291 ? 137 SER A OG  1 
ATOM   807  N N   . LEU A 1 101 ? -10.61052 -11.91933 4.93797  1.000 17.18344 ? 138 LEU A N   1 
ATOM   808  C CA  . LEU A 1 101 ? -9.63705  -12.56291 5.80566  1.000 26.57197 ? 138 LEU A CA  1 
ATOM   809  C C   . LEU A 1 101 ? -9.01518  -13.76925 5.12114  1.000 26.07135 ? 138 LEU A C   1 
ATOM   810  O O   . LEU A 1 101 ? -9.55517  -14.31795 4.15716  1.000 41.65436 ? 138 LEU A O   1 
ATOM   811  C CB  . LEU A 1 101 ? -10.26557 -13.02164 7.12402  1.000 26.81797 ? 138 LEU A CB  1 
ATOM   812  C CG  . LEU A 1 101 ? -10.69579 -11.96126 8.12715  1.000 26.16514 ? 138 LEU A CG  1 
ATOM   813  C CD1 . LEU A 1 101 ? -11.07011 -12.64972 9.42154  1.000 32.91574 ? 138 LEU A CD1 1 
ATOM   814  C CD2 . LEU A 1 101 ? -9.58488  -10.95595 8.34542  1.000 27.25129 ? 138 LEU A CD2 1 
ATOM   815  N N   . ASN A 1 102 ? -7.86280  -14.17783 5.64994  1.000 25.13374 ? 139 ASN A N   1 
ATOM   816  C CA  . ASN A 1 102 ? -7.26447  -15.45965 5.30382  1.000 30.53566 ? 139 ASN A CA  1 
ATOM   817  C C   . ASN A 1 102 ? -7.62979  -16.55313 6.29638  1.000 24.77729 ? 139 ASN A C   1 
ATOM   818  O O   . ASN A 1 102 ? -7.62560  -17.73540 5.93501  1.000 40.10768 ? 139 ASN A O   1 
ATOM   819  C CB  . ASN A 1 102 ? -5.74113  -15.33209 5.23421  1.000 27.01012 ? 139 ASN A CB  1 
ATOM   820  C CG  . ASN A 1 102 ? -5.12247  -15.00776 6.58339  1.000 33.48170 ? 139 ASN A CG  1 
ATOM   821  O OD1 . ASN A 1 102 ? -5.66529  -14.21524 7.35472  1.000 29.49918 ? 139 ASN A OD1 1 
ATOM   822  N ND2 . ASN A 1 102 ? -3.98573  -15.62514 6.87659  1.000 32.10885 ? 139 ASN A ND2 1 
ATOM   823  N N   . ALA A 1 103 ? -7.94503  -16.18182 7.53421  1.000 34.15959 ? 140 ALA A N   1 
ATOM   824  C CA  . ALA A 1 103 ? -8.26887  -17.14172 8.57593  1.000 30.83376 ? 140 ALA A CA  1 
ATOM   825  C C   . ALA A 1 103 ? -9.68922  -17.67313 8.40326  1.000 38.30296 ? 140 ALA A C   1 
ATOM   826  O O   . ALA A 1 103 ? -10.53240 -17.07448 7.72936  1.000 32.61182 ? 140 ALA A O   1 
ATOM   827  C CB  . ALA A 1 103 ? -8.11065  -16.50912 9.95946  1.000 25.09330 ? 140 ALA A CB  1 
ATOM   828  N N   . ASP A 1 104 ? -9.94749  -18.81411 9.03679  1.000 26.98109 ? 141 ASP A N   1 
ATOM   829  C CA  . ASP A 1 104 ? -11.23214 -19.48654 8.90701  1.000 30.89490 ? 141 ASP A CA  1 
ATOM   830  C C   . ASP A 1 104 ? -12.26466 -18.83909 9.82564  1.000 30.34855 ? 141 ASP A C   1 
ATOM   831  O O   . ASP A 1 104 ? -12.03241 -18.68997 11.02957 1.000 22.88605 ? 141 ASP A O   1 
ATOM   832  C CB  . ASP A 1 104 ? -11.07309 -20.97310 9.22589  1.000 27.88008 ? 141 ASP A CB  1 
ATOM   833  C CG  . ASP A 1 104 ? -12.32417 -21.77039 8.93601  1.000 23.53093 ? 141 ASP A CG  1 
ATOM   834  O OD1 . ASP A 1 104 ? -13.28852 -21.67621 9.72197  1.000 33.80443 ? 141 ASP A OD1 1 
ATOM   835  O OD2 . ASP A 1 104 ? -12.34478 -22.48543 7.91330  1.000 31.08493 ? 141 ASP A OD2 1 
ATOM   836  N N   . THR A 1 105 ? -13.40836 -18.45504 9.25022  1.000 26.30020 ? 142 THR A N   1 
ATOM   837  C CA  . THR A 1 105 ? -14.44448 -17.77547 10.02497 1.000 28.65032 ? 142 THR A CA  1 
ATOM   838  C C   . THR A 1 105 ? -15.07456 -18.70910 11.05263 1.000 29.87874 ? 142 THR A C   1 
ATOM   839  O O   . THR A 1 105 ? -15.38474 -18.28843 12.17467 1.000 18.83527 ? 142 THR A O   1 
ATOM   840  C CB  . THR A 1 105 ? -15.50628 -17.20311 9.08226  1.000 30.96137 ? 142 THR A CB  1 
ATOM   841  O OG1 . THR A 1 105 ? -14.95137 -16.09767 8.35848  1.000 51.15599 ? 142 THR A OG1 1 
ATOM   842  C CG2 . THR A 1 105 ? -16.73379 -16.73089 9.85182  1.000 43.87044 ? 142 THR A CG2 1 
ATOM   843  N N   . GLY A 1 106 ? -15.26773 -19.97930 10.69160 1.000 26.13637 ? 143 GLY A N   1 
ATOM   844  C CA  . GLY A 1 106 ? -15.78929 -20.93655 11.65338 1.000 14.58954 ? 143 GLY A CA  1 
ATOM   845  C C   . GLY A 1 106 ? -14.87054 -21.12423 12.84611 1.000 28.34114 ? 143 GLY A C   1 
ATOM   846  O O   . GLY A 1 106 ? -15.33392 -21.25951 13.98146 1.000 22.68915 ? 143 GLY A O   1 
ATOM   847  N N   . ASP A 1 107 ? -13.55414 -21.13108 12.60534 1.000 12.00001 ? 144 ASP A N   1 
ATOM   848  C CA  . ASP A 1 107 ? -12.59743 -21.24038 13.70355 1.000 17.84800 ? 144 ASP A CA  1 
ATOM   849  C C   . ASP A 1 107 ? -12.71184 -20.05420 14.65039 1.000 24.45611 ? 144 ASP A C   1 
ATOM   850  O O   . ASP A 1 107 ? -12.63227 -20.21622 15.87364 1.000 23.15316 ? 144 ASP A O   1 
ATOM   851  C CB  . ASP A 1 107 ? -11.16988 -21.34543 13.15935 1.000 18.25502 ? 144 ASP A CB  1 
ATOM   852  C CG  . ASP A 1 107 ? -10.88596 -22.68505 12.49621 1.000 24.68206 ? 144 ASP A CG  1 
ATOM   853  O OD1 . ASP A 1 107 ? -11.75437 -23.58237 12.54048 1.000 26.92498 ? 144 ASP A OD1 1 
ATOM   854  O OD2 . ASP A 1 107 ? -9.78497  -22.83942 11.92768 1.000 32.72790 ? 144 ASP A OD2 1 
ATOM   855  N N   . ILE A 1 108 ? -12.89285 -18.85096 14.10062 1.000 20.48283 ? 145 ILE A N   1 
ATOM   856  C CA  . ILE A 1 108 ? -13.05544 -17.66500 14.93479 1.000 18.17977 ? 145 ILE A CA  1 
ATOM   857  C C   . ILE A 1 108 ? -14.33831 -17.75826 15.74992 1.000 19.19994 ? 145 ILE A C   1 
ATOM   858  O O   . ILE A 1 108 ? -14.36244 -17.41533 16.93815 1.000 22.30282 ? 145 ILE A O   1 
ATOM   859  C CB  . ILE A 1 108 ? -13.02754 -16.39715 14.06253 1.000 20.90669 ? 145 ILE A CB  1 
ATOM   860  C CG1 . ILE A 1 108 ? -11.68833 -16.28805 13.32973 1.000 14.33211 ? 145 ILE A CG1 1 
ATOM   861  C CG2 . ILE A 1 108 ? -13.29111 -15.15430 14.90795 1.000 10.31416 ? 145 ILE A CG2 1 
ATOM   862  C CD1 . ILE A 1 108 ? -11.62851 -15.14972 12.33709 1.000 21.54492 ? 145 ILE A CD1 1 
ATOM   863  N N   . LEU A 1 109 ? -15.42192 -18.22546 15.12672 1.000 20.19920 ? 146 LEU A N   1 
ATOM   864  C CA  . LEU A 1 109 ? -16.69451 -18.35435 15.82962 1.000 22.90843 ? 146 LEU A CA  1 
ATOM   865  C C   . LEU A 1 109 ? -16.59304 -19.37024 16.96206 1.000 23.61179 ? 146 LEU A C   1 
ATOM   866  O O   . LEU A 1 109 ? -16.97962 -19.09006 18.10304 1.000 19.88502 ? 146 LEU A O   1 
ATOM   867  C CB  . LEU A 1 109 ? -17.79073 -18.74827 14.83668 1.000 20.60262 ? 146 LEU A CB  1 
ATOM   868  C CG  . LEU A 1 109 ? -19.21592 -18.97856 15.34653 1.000 28.00126 ? 146 LEU A CG  1 
ATOM   869  C CD1 . LEU A 1 109 ? -19.86037 -17.67666 15.79593 1.000 15.52027 ? 146 LEU A CD1 1 
ATOM   870  C CD2 . LEU A 1 109 ? -20.05678 -19.64518 14.26901 1.000 18.14302 ? 146 LEU A CD2 1 
ATOM   871  N N   . ARG A 1 110 ? -16.05463 -20.55473 16.66550 1.000 20.46549 ? 147 ARG A N   1 
ATOM   872  C CA  . ARG A 1 110 ? -15.95248 -21.59870 17.67833 1.000 19.79632 ? 147 ARG A CA  1 
ATOM   873  C C   . ARG A 1 110 ? -15.01282 -21.19072 18.80640 1.000 25.77405 ? 147 ARG A C   1 
ATOM   874  O O   . ARG A 1 110 ? -15.32236 -21.40232 19.98528 1.000 22.92022 ? 147 ARG A O   1 
ATOM   875  C CB  . ARG A 1 110 ? -15.48768 -22.90630 17.03390 1.000 24.22837 ? 147 ARG A CB  1 
ATOM   876  C CG  . ARG A 1 110 ? -15.40156 -24.08179 17.99929 1.000 33.11719 ? 147 ARG A CG  1 
ATOM   877  C CD  . ARG A 1 110 ? -15.12167 -25.39608 17.27510 1.000 40.42369 ? 147 ARG A CD  1 
ATOM   878  N NE  . ARG A 1 110 ? -13.85498 -25.37410 16.54640 1.000 50.50900 ? 147 ARG A NE  1 
ATOM   879  C CZ  . ARG A 1 110 ? -13.74882 -25.23500 15.22775 1.000 47.33734 ? 147 ARG A CZ  1 
ATOM   880  N NH1 . ARG A 1 110 ? -14.83826 -25.10808 14.48017 1.000 41.14468 ? 147 ARG A NH1 1 
ATOM   881  N NH2 . ARG A 1 110 ? -12.55175 -25.22567 14.65523 1.000 37.52720 ? 147 ARG A NH2 1 
ATOM   882  N N   . SER A 1 111 ? -13.86213 -20.59825 18.46693 1.000 12.50791 ? 148 SER A N   1 
ATOM   883  C CA  . SER A 1 111 ? -12.88770 -20.23597 19.49280 1.000 19.59255 ? 148 SER A CA  1 
ATOM   884  C C   . SER A 1 111 ? -13.42573 -19.14714 20.41251 1.000 17.49059 ? 148 SER A C   1 
ATOM   885  O O   . SER A 1 111 ? -13.21705 -19.19819 21.63032 1.000 22.42478 ? 148 SER A O   1 
ATOM   886  C CB  . SER A 1 111 ? -11.57588 -19.78712 18.84660 1.000 14.48532 ? 148 SER A CB  1 
ATOM   887  O OG  . SER A 1 111 ? -11.02359 -20.81240 18.04170 1.000 48.15426 ? 148 SER A OG  1 
ATOM   888  N N   . ALA A 1 112 ? -14.11579 -18.15148 19.85193 1.000 16.71907 ? 149 ALA A N   1 
ATOM   889  C CA  . ALA A 1 112 ? -14.66827 -17.08832 20.68483 1.000 14.68349 ? 149 ALA A CA  1 
ATOM   890  C C   . ALA A 1 112 ? -15.75425 -17.62193 21.61137 1.000 14.49398 ? 149 ALA A C   1 
ATOM   891  O O   . ALA A 1 112 ? -15.88279 -17.16488 22.75246 1.000 16.99487 ? 149 ALA A O   1 
ATOM   892  C CB  . ALA A 1 112 ? -15.20898 -15.96103 19.80872 1.000 13.47590 ? 149 ALA A CB  1 
ATOM   893  N N   . ARG A 1 113 ? -16.54161 -18.59278 21.14103 1.000 18.23202 ? 150 ARG A N   1 
ATOM   894  C CA  . ARG A 1 113 ? -17.55629 -19.20017 21.99689 1.000 17.25932 ? 150 ARG A CA  1 
ATOM   895  C C   . ARG A 1 113 ? -16.91938 -19.95665 23.15650 1.000 23.48368 ? 150 ARG A C   1 
ATOM   896  O O   . ARG A 1 113 ? -17.44873 -19.95039 24.27375 1.000 22.66846 ? 150 ARG A O   1 
ATOM   897  C CB  . ARG A 1 113 ? -18.45285 -20.12363 21.17187 1.000 15.08426 ? 150 ARG A CB  1 
ATOM   898  C CG  . ARG A 1 113 ? -19.40479 -19.38740 20.23514 1.000 15.04428 ? 150 ARG A CG  1 
ATOM   899  C CD  . ARG A 1 113 ? -20.09785 -20.34440 19.27239 1.000 15.56051 ? 150 ARG A CD  1 
ATOM   900  N NE  . ARG A 1 113 ? -21.16222 -19.68535 18.51901 1.000 21.58920 ? 150 ARG A NE  1 
ATOM   901  C CZ  . ARG A 1 113 ? -21.78216 -20.21867 17.46987 1.000 22.72531 ? 150 ARG A CZ  1 
ATOM   902  N NH1 . ARG A 1 113 ? -21.44244 -21.42460 17.03404 1.000 20.29581 ? 150 ARG A NH1 1 
ATOM   903  N NH2 . ARG A 1 113 ? -22.74032 -19.54327 16.85095 1.000 18.64549 ? 150 ARG A NH2 1 
ATOM   904  N N   . ARG A 1 114 ? -15.77380 -20.59994 22.91691 1.000 26.31312 ? 151 ARG A N   1 
ATOM   905  C CA  . ARG A 1 114 ? -15.09142 -21.31186 23.99310 1.000 27.26339 ? 151 ARG A CA  1 
ATOM   906  C C   . ARG A 1 114 ? -14.48110 -20.34457 25.00124 1.000 27.67019 ? 151 ARG A C   1 
ATOM   907  O O   . ARG A 1 114 ? -14.55775 -20.57548 26.21349 1.000 30.74118 ? 151 ARG A O   1 
ATOM   908  C CB  . ARG A 1 114 ? -14.01826 -22.23622 23.41589 1.000 28.80203 ? 151 ARG A CB  1 
ATOM   909  C CG  . ARG A 1 114 ? -13.19898 -22.97082 24.46921 1.000 40.22304 ? 151 ARG A CG  1 
ATOM   910  C CD  . ARG A 1 114 ? -14.09498 -23.70295 25.46201 1.000 44.31614 ? 151 ARG A CD  1 
ATOM   911  N NE  . ARG A 1 114 ? -13.33684 -24.27660 26.57067 1.000 43.32783 ? 151 ARG A NE  1 
ATOM   912  C CZ  . ARG A 1 114 ? -12.91947 -23.58710 27.62843 1.000 43.72145 ? 151 ARG A CZ  1 
ATOM   913  N NH1 . ARG A 1 114 ? -13.17707 -22.28980 27.72421 1.000 29.01491 ? 151 ARG A NH1 1 
ATOM   914  N NH2 . ARG A 1 114 ? -12.23684 -24.19295 28.58969 1.000 49.49550 ? 151 ARG A NH2 1 
ATOM   915  N N   . ALA A 1 115 ? -13.87179 -19.25595 24.52281 1.000 22.08954 ? 152 ALA A N   1 
ATOM   916  C CA  . ALA A 1 115 ? -13.25561 -18.29645 25.43439 1.000 21.29117 ? 152 ALA A CA  1 
ATOM   917  C C   . ALA A 1 115 ? -14.29075 -17.59184 26.30234 1.000 17.20937 ? 152 ALA A C   1 
ATOM   918  O O   . ALA A 1 115 ? -13.97743 -17.18355 27.42604 1.000 20.33620 ? 152 ALA A O   1 
ATOM   919  C CB  . ALA A 1 115 ? -12.43950 -17.26845 24.64937 1.000 14.02046 ? 152 ALA A CB  1 
ATOM   920  N N   . ALA A 1 116 ? -15.52093 -17.43882 25.80401 1.000 12.42651 ? 153 ALA A N   1 
ATOM   921  C CA  . ALA A 1 116 ? -16.55325 -16.75477 26.57574 1.000 23.55502 ? 153 ALA A CA  1 
ATOM   922  C C   . ALA A 1 116 ? -16.88814 -17.50605 27.85730 1.000 20.21547 ? 153 ALA A C   1 
ATOM   923  O O   . ALA A 1 116 ? -17.31873 -16.89281 28.84028 1.000 20.54169 ? 153 ALA A O   1 
ATOM   924  C CB  . ALA A 1 116 ? -17.80922 -16.56831 25.72491 1.000 16.57423 ? 153 ALA A CB  1 
ATOM   925  N N   . VAL A 1 117 ? -16.70463 -18.82844 27.86349 1.000 25.27188 ? 154 VAL A N   1 
ATOM   926  C CA  . VAL A 1 117 ? -16.90243 -19.60673 29.08304 1.000 27.84004 ? 154 VAL A CA  1 
ATOM   927  C C   . VAL A 1 117 ? -16.01833 -19.07263 30.20104 1.000 27.71984 ? 154 VAL A C   1 
ATOM   928  O O   . VAL A 1 117 ? -16.45084 -18.94937 31.35314 1.000 27.51677 ? 154 VAL A O   1 
ATOM   929  C CB  . VAL A 1 117 ? -16.63098 -21.09745 28.81023 1.000 30.53032 ? 154 VAL A CB  1 
ATOM   930  C CG1 . VAL A 1 117 ? -16.75140 -21.90234 30.09208 1.000 25.94142 ? 154 VAL A CG1 1 
ATOM   931  C CG2 . VAL A 1 117 ? -17.58295 -21.62237 27.74441 1.000 21.56737 ? 154 VAL A CG2 1 
ATOM   932  N N   . ASP A 1 118 ? -14.77104 -18.73679 29.87660 1.000 26.57859 ? 155 ASP A N   1 
ATOM   933  C CA  . ASP A 1 118 ? -13.83587 -18.15802 30.82720 1.000 19.45760 ? 155 ASP A CA  1 
ATOM   934  C C   . ASP A 1 118 ? -13.88977 -16.63538 30.84710 1.000 24.66653 ? 155 ASP A C   1 
ATOM   935  O O   . ASP A 1 118 ? -12.92208 -15.99789 31.27871 1.000 25.03773 ? 155 ASP A O   1 
ATOM   936  C CB  . ASP A 1 118 ? -12.41688 -18.63390 30.51408 1.000 38.70523 ? 155 ASP A CB  1 
ATOM   937  C CG  . ASP A 1 118 ? -12.30545 -20.14532 30.49590 1.000 34.80244 ? 155 ASP A CG  1 
ATOM   938  O OD1 . ASP A 1 118 ? -12.91641 -20.79416 31.37090 1.000 44.22516 ? 155 ASP A OD1 1 
ATOM   939  O OD2 . ASP A 1 118 ? -11.61904 -20.68499 29.60288 1.000 37.66459 ? 155 ASP A OD2 1 
ATOM   940  N N   . GLU A 1 119 ? -14.99728 -16.04453 30.38915 1.000 18.69624 ? 156 GLU A N   1 
ATOM   941  C CA  . GLU A 1 119 ? -15.17283 -14.59110 30.35091 1.000 28.33713 ? 156 GLU A CA  1 
ATOM   942  C C   . GLU A 1 119 ? -14.05291 -13.90764 29.57012 1.000 25.98641 ? 156 GLU A C   1 
ATOM   943  O O   . GLU A 1 119 ? -13.63943 -12.79185 29.89744 1.000 20.39939 ? 156 GLU A O   1 
ATOM   944  C CB  . GLU A 1 119 ? -15.27442 -14.00576 31.76352 1.000 25.73350 ? 156 GLU A CB  1 
ATOM   945  C CG  . GLU A 1 119 ? -16.31376 -14.68094 32.65146 1.000 21.27385 ? 156 GLU A CG  1 
ATOM   946  C CD  . GLU A 1 119 ? -17.71386 -14.61783 32.06856 1.000 23.53025 ? 156 GLU A CD  1 
ATOM   947  O OE1 . GLU A 1 119 ? -18.41942 -15.64846 32.09053 1.000 38.97503 ? 156 GLU A OE1 1 
ATOM   948  O OE2 . GLU A 1 119 ? -18.10844 -13.53886 31.58075 1.000 23.16056 ? 156 GLU A OE2 1 
ATOM   949  N N   . ALA A 1 120 ? -13.55590 -14.56682 28.52917 1.000 18.90768 ? 157 ALA A N   1 
ATOM   950  C CA  . ALA A 1 120 ? -12.40083 -14.09005 27.78972 1.000 21.01955 ? 157 ALA A CA  1 
ATOM   951  C C   . ALA A 1 120 ? -12.74897 -13.87432 26.32319 1.000 24.12172 ? 157 ALA A C   1 
ATOM   952  O O   . ALA A 1 120 ? -13.77164 -14.34959 25.82114 1.000 21.59106 ? 157 ALA A O   1 
ATOM   953  C CB  . ALA A 1 120 ? -11.22848 -15.07291 27.90273 1.000 16.85044 ? 157 ALA A CB  1 
ATOM   954  N N   . ALA A 1 121 ? -11.87798 -13.13721 25.64600 1.000 18.58678 ? 158 ALA A N   1 
ATOM   955  C CA  . ALA A 1 121 ? -11.91205 -12.97201 24.20336 1.000 12.25524 ? 158 ALA A CA  1 
ATOM   956  C C   . ALA A 1 121 ? -10.72951 -13.70695 23.58778 1.000 16.84987 ? 158 ALA A C   1 
ATOM   957  O O   . ALA A 1 121 ? -9.85525  -14.22423 24.28719 1.000 17.81559 ? 158 ALA A O   1 
ATOM   958  C CB  . ALA A 1 121 ? -11.88249 -11.48713 23.82038 1.000 10.70779 ? 158 ALA A CB  1 
ATOM   959  N N   . ILE A 1 122 ? -10.71103 -13.75612 22.25931 1.000 15.92096 ? 159 ILE A N   1 
ATOM   960  C CA  . ILE A 1 122 ? -9.58023  -14.30992 21.53164 1.000 15.21062 ? 159 ILE A CA  1 
ATOM   961  C C   . ILE A 1 122 ? -8.96971  -13.20863 20.67882 1.000 13.31116 ? 159 ILE A C   1 
ATOM   962  O O   . ILE A 1 122 ? -9.60812  -12.20331 20.36021 1.000 15.62170 ? 159 ILE A O   1 
ATOM   963  C CB  . ILE A 1 122 ? -9.96759  -15.51669 20.65228 1.000 14.90577 ? 159 ILE A CB  1 
ATOM   964  C CG1 . ILE A 1 122 ? -10.93648 -15.08469 19.54996 1.000 17.18445 ? 159 ILE A CG1 1 
ATOM   965  C CG2 . ILE A 1 122 ? -10.55289 -16.63035 21.50133 1.000 10.33795 ? 159 ILE A CG2 1 
ATOM   966  C CD1 . ILE A 1 122 ? -11.19078 -16.15151 18.51289 1.000 30.74103 ? 159 ILE A CD1 1 
ATOM   967  N N   . SER A 1 123 ? -7.70942  -13.41032 20.31126 1.000 14.40607 ? 160 SER A N   1 
ATOM   968  C CA  . SER A 1 123 ? -7.04425  -12.50719 19.38947 1.000 14.57690 ? 160 SER A CA  1 
ATOM   969  C C   . SER A 1 123 ? -6.08491  -13.30960 18.52689 1.000 15.71805 ? 160 SER A C   1 
ATOM   970  O O   . SER A 1 123 ? -5.67026  -14.41476 18.88487 1.000 19.13160 ? 160 SER A O   1 
ATOM   971  C CB  . SER A 1 123 ? -6.30555  -11.37864 20.12170 1.000 15.22665 ? 160 SER A CB  1 
ATOM   972  O OG  . SER A 1 123 ? -5.26754  -11.88447 20.94003 1.000 22.43574 ? 160 SER A OG  1 
ATOM   973  N N   . ARG A 1 124 ? -5.74643  -12.73928 17.37659 1.000 18.04828 ? 161 ARG A N   1 
ATOM   974  C CA  . ARG A 1 124 ? -4.78990  -13.34108 16.45800 1.000 16.36419 ? 161 ARG A CA  1 
ATOM   975  C C   . ARG A 1 124 ? -4.42910  -12.29677 15.41460 1.000 20.34489 ? 161 ARG A C   1 
ATOM   976  O O   . ARG A 1 124 ? -5.04336  -11.22927 15.33734 1.000 17.50422 ? 161 ARG A O   1 
ATOM   977  C CB  . ARG A 1 124 ? -5.34741  -14.59948 15.78803 1.000 15.48416 ? 161 ARG A CB  1 
ATOM   978  C CG  . ARG A 1 124 ? -6.58390  -14.35506 14.94003 1.000 14.15101 ? 161 ARG A CG  1 
ATOM   979  C CD  . ARG A 1 124 ? -6.81556  -15.51190 13.98428 1.000 19.31074 ? 161 ARG A CD  1 
ATOM   980  N NE  . ARG A 1 124 ? -5.72086  -15.64157 13.02567 1.000 17.19486 ? 161 ARG A NE  1 
ATOM   981  C CZ  . ARG A 1 124 ? -5.48963  -16.72697 12.29537 1.000 20.10261 ? 161 ARG A CZ  1 
ATOM   982  N NH1 . ARG A 1 124 ? -6.27544  -17.78939 12.41430 1.000 21.84670 ? 161 ARG A NH1 1 
ATOM   983  N NH2 . ARG A 1 124 ? -4.46975  -16.75169 11.44881 1.000 15.52604 ? 161 ARG A NH2 1 
ATOM   984  N N   . TYR A 1 125 ? -3.42282  -12.61899 14.61144 1.000 12.60104 ? 162 TYR A N   1 
ATOM   985  C CA  . TYR A 1 125 ? -3.06273  -11.80493 13.46344 1.000 18.45978 ? 162 TYR A CA  1 
ATOM   986  C C   . TYR A 1 125 ? -3.69514  -12.39828 12.21502 1.000 13.50030 ? 162 TYR A C   1 
ATOM   987  O O   . TYR A 1 125 ? -3.77816  -13.62044 12.06805 1.000 19.37543 ? 162 TYR A O   1 
ATOM   988  C CB  . TYR A 1 125 ? -1.54515  -11.71006 13.30895 1.000 7.83993  ? 162 TYR A CB  1 
ATOM   989  C CG  . TYR A 1 125 ? -0.87705  -11.16010 14.54474 1.000 18.23649 ? 162 TYR A CG  1 
ATOM   990  C CD1 . TYR A 1 125 ? -1.07444  -9.84062  14.93401 1.000 15.00968 ? 162 TYR A CD1 1 
ATOM   991  C CD2 . TYR A 1 125 ? -0.06245  -11.96136 15.33166 1.000 20.06455 ? 162 TYR A CD2 1 
ATOM   992  C CE1 . TYR A 1 125 ? -0.47365  -9.33502  16.07094 1.000 21.09962 ? 162 TYR A CE1 1 
ATOM   993  C CE2 . TYR A 1 125 ? 0.54350   -11.46439 16.46726 1.000 24.52064 ? 162 TYR A CE2 1 
ATOM   994  C CZ  . TYR A 1 125 ? 0.33467   -10.15223 16.83302 1.000 15.47903 ? 162 TYR A CZ  1 
ATOM   995  O OH  . TYR A 1 125 ? 0.93962   -9.65833  17.96464 1.000 26.60652 ? 162 TYR A OH  1 
ATOM   996  N N   . VAL A 1 126 ? -4.15883  -11.52376 11.32566 1.000 13.48270 ? 163 VAL A N   1 
ATOM   997  C CA  . VAL A 1 126 ? -4.85448  -11.93545 10.11764 1.000 17.96861 ? 163 VAL A CA  1 
ATOM   998  C C   . VAL A 1 126 ? -4.29223  -11.15670 8.93920  1.000 21.50505 ? 163 VAL A C   1 
ATOM   999  O O   . VAL A 1 126 ? -3.69274  -10.09027 9.09294  1.000 16.01231 ? 163 VAL A O   1 
ATOM   1000 C CB  . VAL A 1 126 ? -6.38096  -11.71834 10.21721 1.000 14.54848 ? 163 VAL A CB  1 
ATOM   1001 C CG1 . VAL A 1 126 ? -6.98828  -12.62539 11.27713 1.000 13.39245 ? 163 VAL A CG1 1 
ATOM   1002 C CG2 . VAL A 1 126 ? -6.68659  -10.25660 10.52109 1.000 11.15007 ? 163 VAL A CG2 1 
ATOM   1003 N N   . ASP A 1 127 ? -4.48485  -11.71802 7.75069  1.000 20.59489 ? 164 ASP A N   1 
ATOM   1004 C CA  . ASP A 1 127 ? -4.25938  -10.99964 6.50433  1.000 16.21928 ? 164 ASP A CA  1 
ATOM   1005 C C   . ASP A 1 127 ? -5.57847  -10.33777 6.12414  1.000 20.93717 ? 164 ASP A C   1 
ATOM   1006 O O   . ASP A 1 127 ? -6.53444  -11.01993 5.74117  1.000 35.17223 ? 164 ASP A O   1 
ATOM   1007 C CB  . ASP A 1 127 ? -3.76976  -11.94667 5.41271  1.000 21.05473 ? 164 ASP A CB  1 
ATOM   1008 C CG  . ASP A 1 127 ? -3.40816  -11.22305 4.13131  1.000 19.94746 ? 164 ASP A CG  1 
ATOM   1009 O OD1 . ASP A 1 127 ? -3.34011  -9.97598  4.14463  1.000 22.68956 ? 164 ASP A OD1 1 
ATOM   1010 O OD2 . ASP A 1 127 ? -3.19241  -11.90361 3.10797  1.000 42.25135 ? 164 ASP A OD2 1 
ATOM   1011 N N   . PHE A 1 128 ? -5.63878  -9.01511  6.25011  1.000 17.05266 ? 165 PHE A N   1 
ATOM   1012 C CA  . PHE A 1 128 ? -6.87011  -8.25328  6.05484  1.000 21.94191 ? 165 PHE A CA  1 
ATOM   1013 C C   . PHE A 1 128 ? -6.68988  -7.35754  4.83313  1.000 32.20173 ? 165 PHE A C   1 
ATOM   1014 O O   . PHE A 1 128 ? -6.09037  -6.28175  4.92539  1.000 26.69576 ? 165 PHE A O   1 
ATOM   1015 C CB  . PHE A 1 128 ? -7.20284  -7.44725  7.30784  1.000 23.64800 ? 165 PHE A CB  1 
ATOM   1016 C CG  . PHE A 1 128 ? -8.53976  -6.76506  7.25845  1.000 33.08736 ? 165 PHE A CG  1 
ATOM   1017 C CD1 . PHE A 1 128 ? -9.71092  -7.50542  7.24336  1.000 35.16271 ? 165 PHE A CD1 1 
ATOM   1018 C CD2 . PHE A 1 128 ? -8.62661  -5.38220  7.24677  1.000 32.06146 ? 165 PHE A CD2 1 
ATOM   1019 C CE1 . PHE A 1 128 ? -10.94257 -6.87792  7.20464  1.000 33.74610 ? 165 PHE A CE1 1 
ATOM   1020 C CE2 . PHE A 1 128 ? -9.85542  -4.74900  7.20867  1.000 27.62557 ? 165 PHE A CE2 1 
ATOM   1021 C CZ  . PHE A 1 128 ? -11.01406 -5.49711  7.18728  1.000 26.71741 ? 165 PHE A CZ  1 
ATOM   1022 N N   . ASP A 1 129 ? -7.21623  -7.80992  3.69074  1.000 28.71158 ? 166 ASP A N   1 
ATOM   1023 C CA  . ASP A 1 129 ? -7.11506  -7.08596  2.42062  1.000 33.88090 ? 166 ASP A CA  1 
ATOM   1024 C C   . ASP A 1 129 ? -5.65902  -6.79986  2.06076  1.000 31.15320 ? 166 ASP A C   1 
ATOM   1025 O O   . ASP A 1 129 ? -5.29422  -5.68413  1.68505  1.000 46.40496 ? 166 ASP A O   1 
ATOM   1026 C CB  . ASP A 1 129 ? -7.93379  -5.79264  2.44975  1.000 33.47429 ? 166 ASP A CB  1 
ATOM   1027 C CG  . ASP A 1 129 ? -9.39401  -6.02381  2.13547  1.000 45.33786 ? 166 ASP A CG  1 
ATOM   1028 O OD1 . ASP A 1 129 ? -9.78013  -7.19640  1.93916  1.000 39.76788 ? 166 ASP A OD1 1 
ATOM   1029 O OD2 . ASP A 1 129 ? -10.15352 -5.03361  2.07850  1.000 50.03171 ? 166 ASP A OD2 1 
ATOM   1030 N N   . GLY A 1 130 ? -4.82106  -7.82783  2.17951  1.000 31.84700 ? 167 GLY A N   1 
ATOM   1031 C CA  . GLY A 1 130 ? -3.41560  -7.70406  1.86510  1.000 20.68040 ? 167 GLY A CA  1 
ATOM   1032 C C   . GLY A 1 130 ? -2.58423  -6.98021  2.89892  1.000 30.53015 ? 167 GLY A C   1 
ATOM   1033 O O   . GLY A 1 130 ? -1.38258  -6.78412  2.67395  1.000 37.67261 ? 167 GLY A O   1 
ATOM   1034 N N   . ALA A 1 131 ? -3.17476  -6.57850  4.02212  1.000 24.55188 ? 168 ALA A N   1 
ATOM   1035 C CA  . ALA A 1 131 ? -2.45726  -5.85383  5.05444  1.000 20.35206 ? 168 ALA A CA  1 
ATOM   1036 C C   . ALA A 1 131 ? -2.47272  -6.63402  6.36252  1.000 18.46408 ? 168 ALA A C   1 
ATOM   1037 O O   . ALA A 1 131 ? -3.43408  -7.35443  6.64786  1.000 21.96002 ? 168 ALA A O   1 
ATOM   1038 C CB  . ALA A 1 131 ? -3.07041  -4.46714  5.28363  1.000 24.06417 ? 168 ALA A CB  1 
ATOM   1039 N N   . PRO A 1 132 ? -1.42384  -6.51830  7.17375  1.000 18.47461 ? 169 PRO A N   1 
ATOM   1040 C CA  . PRO A 1 132 ? -1.44803  -7.15855  8.49073  1.000 22.22639 ? 169 PRO A CA  1 
ATOM   1041 C C   . PRO A 1 132 ? -2.49023  -6.50681  9.38251  1.000 18.45400 ? 169 PRO A C   1 
ATOM   1042 O O   . PRO A 1 132 ? -2.80004  -5.31958  9.25353  1.000 16.51987 ? 169 PRO A O   1 
ATOM   1043 C CB  . PRO A 1 132 ? -0.03033  -6.92666  9.02453  1.000 13.74533 ? 169 PRO A CB  1 
ATOM   1044 C CG  . PRO A 1 132 ? 0.41334   -5.67603  8.33856  1.000 19.96138 ? 169 PRO A CG  1 
ATOM   1045 C CD  . PRO A 1 132 ? -0.18903  -5.74365  6.96124  1.000 18.73272 ? 169 PRO A CD  1 
ATOM   1046 N N   . ALA A 1 133 ? -3.04175  -7.30098  10.29419 1.000 12.41574 ? 170 ALA A N   1 
ATOM   1047 C CA  . ALA A 1 133 ? -4.08441  -6.77836  11.16137 1.000 16.42981 ? 170 ALA A CA  1 
ATOM   1048 C C   . ALA A 1 133 ? -4.15799  -7.60520  12.43342 1.000 18.73716 ? 170 ALA A C   1 
ATOM   1049 O O   . ALA A 1 133 ? -3.82144  -8.79285  12.44474 1.000 15.35483 ? 170 ALA A O   1 
ATOM   1050 C CB  . ALA A 1 133 ? -5.44594  -6.76785  10.45717 1.000 10.84836 ? 170 ALA A CB  1 
ATOM   1051 N N   . ILE A 1 134 ? -4.60107  -6.95527  13.50246 1.000 11.81517 ? 171 ILE A N   1 
ATOM   1052 C CA  . ILE A 1 134 ? -4.92266  -7.62043  14.75500 1.000 11.46207 ? 171 ILE A CA  1 
ATOM   1053 C C   . ILE A 1 134 ? -6.42730  -7.83322  14.78481 1.000 17.19730 ? 171 ILE A C   1 
ATOM   1054 O O   . ILE A 1 134 ? -7.20249  -6.87751  14.65230 1.000 16.90310 ? 171 ILE A O   1 
ATOM   1055 C CB  . ILE A 1 134 ? -4.45526  -6.80249  15.96787 1.000 16.95495 ? 171 ILE A CB  1 
ATOM   1056 C CG1 . ILE A 1 134 ? -2.93288  -6.64783  15.95400 1.000 12.06205 ? 171 ILE A CG1 1 
ATOM   1057 C CG2 . ILE A 1 134 ? -4.92460  -7.45780  17.26084 1.000 14.08369 ? 171 ILE A CG2 1 
ATOM   1058 C CD1 . ILE A 1 134 ? -2.40331  -5.79945  17.08631 1.000 13.56920 ? 171 ILE A CD1 1 
ATOM   1059 N N   . LEU A 1 135 ? -6.84239  -9.08309  14.93985 1.000 10.22610 ? 172 LEU A N   1 
ATOM   1060 C CA  . LEU A 1 135 ? -8.24775  -9.43244  15.06362 1.000 11.01308 ? 172 LEU A CA  1 
ATOM   1061 C C   . LEU A 1 135 ? -8.52701  -9.84374  16.49991 1.000 16.15050 ? 172 LEU A C   1 
ATOM   1062 O O   . LEU A 1 135 ? -7.80374  -10.67047 17.06083 1.000 16.23115 ? 172 LEU A O   1 
ATOM   1063 C CB  . LEU A 1 135 ? -8.61960  -10.56378 14.10145 1.000 18.22973 ? 172 LEU A CB  1 
ATOM   1064 C CG  . LEU A 1 135 ? -10.07569 -11.03994 14.09048 1.000 24.12178 ? 172 LEU A CG  1 
ATOM   1065 C CD1 . LEU A 1 135 ? -10.46092 -11.47245 12.69364 1.000 22.34443 ? 172 LEU A CD1 1 
ATOM   1066 C CD2 . LEU A 1 135 ? -10.30910 -12.18509 15.07222 1.000 20.72940 ? 172 LEU A CD2 1 
ATOM   1067 N N   . VAL A 1 136 ? -9.56438  -9.26208  17.09233 1.000 11.98652 ? 173 VAL A N   1 
ATOM   1068 C CA  . VAL A 1 136 ? -10.08037 -9.72547  18.37184 1.000 14.01750 ? 173 VAL A CA  1 
ATOM   1069 C C   . VAL A 1 136 ? -11.54244 -10.09045 18.17754 1.000 13.80938 ? 173 VAL A C   1 
ATOM   1070 O O   . VAL A 1 136 ? -12.23304 -9.53867  17.31394 1.000 14.67646 ? 173 VAL A O   1 
ATOM   1071 C CB  . VAL A 1 136 ? -9.91506  -8.68509  19.50427 1.000 16.90603 ? 173 VAL A CB  1 
ATOM   1072 C CG1 . VAL A 1 136 ? -8.45122  -8.28387  19.64593 1.000 13.20388 ? 173 VAL A CG1 1 
ATOM   1073 C CG2 . VAL A 1 136 ? -10.79601 -7.46914  19.25905 1.000 9.66388  ? 173 VAL A CG2 1 
ATOM   1074 N N   . ALA A 1 137 ? -12.00881 -11.04308 18.97804 1.000 10.80924 ? 174 ALA A N   1 
ATOM   1075 C CA  . ALA A 1 137 ? -13.37452 -11.52472 18.86023 1.000 9.37863  ? 174 ALA A CA  1 
ATOM   1076 C C   . ALA A 1 137 ? -13.84124 -12.03038 20.21411 1.000 8.66557  ? 174 ALA A C   1 
ATOM   1077 O O   . ALA A 1 137 ? -13.06024 -12.61378 20.97057 1.000 13.67374 ? 174 ALA A O   1 
ATOM   1078 C CB  . ALA A 1 137 ? -13.49083 -12.63302 17.80817 1.000 6.14185  ? 174 ALA A CB  1 
ATOM   1079 N N   . SER A 1 138 ? -15.11499 -11.79536 20.51435 1.000 8.00281  ? 175 SER A N   1 
ATOM   1080 C CA  . SER A 1 138 ? -15.70852 -12.29208 21.74417 1.000 17.60903 ? 175 SER A CA  1 
ATOM   1081 C C   . SER A 1 138 ? -17.18088 -12.58028 21.49848 1.000 15.96597 ? 175 SER A C   1 
ATOM   1082 O O   . SER A 1 138 ? -17.82452 -11.93823 20.66354 1.000 12.45791 ? 175 SER A O   1 
ATOM   1083 C CB  . SER A 1 138 ? -15.53433 -11.29835 22.89874 1.000 10.40760 ? 175 SER A CB  1 
ATOM   1084 O OG  . SER A 1 138 ? -15.97313 -10.00453 22.52966 1.000 11.85910 ? 175 SER A OG  1 
ATOM   1085 N N   . ALA A 1 139 ? -17.70525 -13.55820 22.23054 1.000 13.98845 ? 176 ALA A N   1 
ATOM   1086 C CA  . ALA A 1 139 ? -19.09867 -13.94122 22.06242 1.000 15.67121 ? 176 ALA A CA  1 
ATOM   1087 C C   . ALA A 1 139 ? -20.02138 -12.83173 22.54653 1.000 12.78248 ? 176 ALA A C   1 
ATOM   1088 O O   . ALA A 1 139 ? -19.72989 -12.13718 23.52401 1.000 13.73678 ? 176 ALA A O   1 
ATOM   1089 C CB  . ALA A 1 139 ? -19.39335 -15.23445 22.81967 1.000 12.96105 ? 176 ALA A CB  1 
ATOM   1090 N N   . ILE A 1 140 ? -21.13621 -12.66293 21.84611 1.000 10.95885 ? 177 ILE A N   1 
ATOM   1091 C CA  . ILE A 1 140 ? -22.17509 -11.72255 22.24348 1.000 17.20453 ? 177 ILE A CA  1 
ATOM   1092 C C   . ILE A 1 140 ? -23.10433 -12.45748 23.20310 1.000 30.52541 ? 177 ILE A C   1 
ATOM   1093 O O   . ILE A 1 140 ? -23.80453 -13.39501 22.81105 1.000 25.17723 ? 177 ILE A O   1 
ATOM   1094 C CB  . ILE A 1 140 ? -22.93437 -11.17770 21.02874 1.000 17.98201 ? 177 ILE A CB  1 
ATOM   1095 C CG1 . ILE A 1 140 ? -21.95290 -10.57787 20.01730 1.000 16.29839 ? 177 ILE A CG1 1 
ATOM   1096 C CG2 . ILE A 1 140 ? -23.95624 -10.13877 21.46223 1.000 17.01328 ? 177 ILE A CG2 1 
ATOM   1097 C CD1 . ILE A 1 140 ? -22.59175 -10.19164 18.69593 1.000 10.37731 ? 177 ILE A CD1 1 
ATOM   1098 N N   . LYS A 1 141 ? -23.09809 -12.04368 24.46685 1.000 18.19425 ? 178 LYS A N   1 
ATOM   1099 C CA  . LYS A 1 141 ? -23.87921 -12.69803 25.50456 1.000 14.87149 ? 178 LYS A CA  1 
ATOM   1100 C C   . LYS A 1 141 ? -24.32332 -11.64312 26.50367 1.000 23.40163 ? 178 LYS A C   1 
ATOM   1101 O O   . LYS A 1 141 ? -23.66617 -10.60381 26.63416 1.000 22.78539 ? 178 LYS A O   1 
ATOM   1102 C CB  . LYS A 1 141 ? -23.06888 -13.79225 26.21579 1.000 25.31378 ? 178 LYS A CB  1 
ATOM   1103 C CG  . LYS A 1 141 ? -21.90240 -13.26504 27.03671 1.000 22.73902 ? 178 LYS A CG  1 
ATOM   1104 C CD  . LYS A 1 141 ? -21.16769 -14.39169 27.74570 1.000 19.54140 ? 178 LYS A CD  1 
ATOM   1105 C CE  . LYS A 1 141 ? -20.11185 -13.84296 28.69023 1.000 22.99671 ? 178 LYS A CE  1 
ATOM   1106 N NZ  . LYS A 1 141 ? -19.59752 -14.88299 29.61987 1.000 40.63693 ? 178 LYS A NZ  1 
ATOM   1107 N N   . PRO A 1 142 ? -25.42465 -11.87018 27.20911 1.000 20.81968 ? 179 PRO A N   1 
ATOM   1108 C CA  . PRO A 1 142 ? -25.87089 -10.90294 28.21418 1.000 16.31778 ? 179 PRO A CA  1 
ATOM   1109 C C   . PRO A 1 142 ? -25.12332 -11.09868 29.52778 1.000 17.43328 ? 179 PRO A C   1 
ATOM   1110 O O   . PRO A 1 142 ? -24.42381 -12.08978 29.74110 1.000 19.75308 ? 179 PRO A O   1 
ATOM   1111 C CB  . PRO A 1 142 ? -27.36079 -11.22037 28.35965 1.000 21.86299 ? 179 PRO A CB  1 
ATOM   1112 C CG  . PRO A 1 142 ? -27.43952 -12.68867 28.09500 1.000 19.68103 ? 179 PRO A CG  1 
ATOM   1113 C CD  . PRO A 1 142 ? -26.36351 -12.99970 27.07567 1.000 16.55111 ? 179 PRO A CD  1 
ATOM   1114 N N   . THR A 1 143 ? -25.28336 -10.12165 30.41549 1.000 17.89014 ? 180 THR A N   1 
ATOM   1115 C CA  . THR A 1 143 ? -24.59557 -10.16362 31.69492 1.000 21.49732 ? 180 THR A CA  1 
ATOM   1116 C C   . THR A 1 143 ? -25.30247 -11.11486 32.66167 1.000 22.60447 ? 180 THR A C   1 
ATOM   1117 O O   . THR A 1 143 ? -26.38521 -11.63901 32.38737 1.000 14.06898 ? 180 THR A O   1 
ATOM   1118 C CB  . THR A 1 143 ? -24.48308 -8.76083  32.28874 1.000 18.22697 ? 180 THR A CB  1 
ATOM   1119 O OG1 . THR A 1 143 ? -25.70785 -8.04597  32.08122 1.000 18.99783 ? 180 THR A OG1 1 
ATOM   1120 C CG2 . THR A 1 143 ? -23.33653 -8.00191  31.62719 1.000 18.86066 ? 180 THR A CG2 1 
ATOM   1121 N N   . SER A 1 144 ? -24.66559 -11.32826 33.81771 1.000 25.01792 ? 181 SER A N   1 
ATOM   1122 C CA  . SER A 1 144 ? -25.08363 -12.38138 34.73930 1.000 19.99658 ? 181 SER A CA  1 
ATOM   1123 C C   . SER A 1 144 ? -26.48727 -12.16956 35.29761 1.000 21.64388 ? 181 SER A C   1 
ATOM   1124 O O   . SER A 1 144 ? -27.09985 -13.13305 35.76887 1.000 18.75261 ? 181 SER A O   1 
ATOM   1125 C CB  . SER A 1 144 ? -24.08069 -12.49550 35.88886 1.000 15.45100 ? 181 SER A CB  1 
ATOM   1126 O OG  . SER A 1 144 ? -24.06879 -11.31774 36.67564 1.000 30.98145 ? 181 SER A OG  1 
ATOM   1127 N N   . ASP A 1 145 ? -27.00888 -10.93947 35.26848 1.000 20.00606 ? 182 ASP A N   1 
ATOM   1128 C CA  . ASP A 1 145 ? -28.38669 -10.70693 35.69249 1.000 22.77468 ? 182 ASP A CA  1 
ATOM   1129 C C   . ASP A 1 145 ? -29.39576 -11.34552 34.74858 1.000 24.07460 ? 182 ASP A C   1 
ATOM   1130 O O   . ASP A 1 145 ? -30.54826 -11.55747 35.13811 1.000 23.82540 ? 182 ASP A O   1 
ATOM   1131 C CB  . ASP A 1 145 ? -28.66573 -9.20833  35.78781 1.000 17.74588 ? 182 ASP A CB  1 
ATOM   1132 C CG  . ASP A 1 145 ? -28.22629 -8.46089  34.54606 1.000 25.36854 ? 182 ASP A CG  1 
ATOM   1133 O OD1 . ASP A 1 145 ? -27.00360 -8.36515  34.31883 1.000 22.60870 ? 182 ASP A OD1 1 
ATOM   1134 O OD2 . ASP A 1 145 ? -29.09867 -7.99115  33.78526 1.000 21.36239 ? 182 ASP A OD2 1 
ATOM   1135 N N   . HIS A 1 146 ? -28.99045 -11.64083 33.52054 1.000 23.05776 ? 183 HIS A N   1 
ATOM   1136 C CA  . HIS A 1 146 ? -29.87318 -12.23248 32.53198 1.000 22.75461 ? 183 HIS A CA  1 
ATOM   1137 C C   . HIS A 1 146 ? -29.90727 -13.74633 32.70087 1.000 32.45833 ? 183 HIS A C   1 
ATOM   1138 O O   . HIS A 1 146 ? -28.96719 -14.35476 33.22137 1.000 26.53826 ? 183 HIS A O   1 
ATOM   1139 C CB  . HIS A 1 146 ? -29.39401 -11.86060 31.12844 1.000 25.15785 ? 183 HIS A CB  1 
ATOM   1140 C CG  . HIS A 1 146 ? -30.37555 -12.15995 30.03914 1.000 18.28395 ? 183 HIS A CG  1 
ATOM   1141 N ND1 . HIS A 1 146 ? -30.50386 -13.41057 29.47417 1.000 21.01176 ? 183 HIS A ND1 1 
ATOM   1142 C CD2 . HIS A 1 146 ? -31.25114 -11.36044 29.38555 1.000 23.39178 ? 183 HIS A CD2 1 
ATOM   1143 C CE1 . HIS A 1 146 ? -31.42933 -13.37266 28.53237 1.000 18.36821 ? 183 HIS A CE1 1 
ATOM   1144 N NE2 . HIS A 1 146 ? -31.89829 -12.14016 28.45828 1.000 31.31103 ? 183 HIS A NE2 1 
ATOM   1145 N N   . ALA A 1 147 ? -31.01248 -14.34960 32.27520 1.000 24.94030 ? 184 ALA A N   1 
ATOM   1146 C CA  . ALA A 1 147 ? -31.09663 -15.80055 32.27086 1.000 24.69311 ? 184 ALA A CA  1 
ATOM   1147 C C   . ALA A 1 147 ? -29.97884 -16.37084 31.40134 1.000 25.44582 ? 184 ALA A C   1 
ATOM   1148 O O   . ALA A 1 147 ? -29.61438 -15.76564 30.38487 1.000 20.44760 ? 184 ALA A O   1 
ATOM   1149 C CB  . ALA A 1 147 ? -32.46100 -16.26187 31.75413 1.000 21.57447 ? 184 ALA A CB  1 
ATOM   1150 N N   . PRO A 1 148 ? -29.40611 -17.51630 31.76968 1.000 25.33607 ? 185 PRO A N   1 
ATOM   1151 C CA  . PRO A 1 148 ? -28.26250 -18.03859 31.01519 1.000 22.10828 ? 185 PRO A CA  1 
ATOM   1152 C C   . PRO A 1 148 ? -28.64923 -18.39542 29.58933 1.000 23.14779 ? 185 PRO A C   1 
ATOM   1153 O O   . PRO A 1 148 ? -29.77445 -18.81308 29.31106 1.000 24.92472 ? 185 PRO A O   1 
ATOM   1154 C CB  . PRO A 1 148 ? -27.84818 -19.28203 31.81095 1.000 26.02251 ? 185 PRO A CB  1 
ATOM   1155 C CG  . PRO A 1 148 ? -29.08224 -19.68695 32.54549 1.000 19.56243 ? 185 PRO A CG  1 
ATOM   1156 C CD  . PRO A 1 148 ? -29.79400 -18.40798 32.87668 1.000 22.60451 ? 185 PRO A CD  1 
ATOM   1157 N N   . ILE A 1 149 ? -27.69622 -18.21645 28.68154 1.000 23.47123 ? 186 ILE A N   1 
ATOM   1158 C CA  . ILE A 1 149 ? -27.88323 -18.54063 27.27808 1.000 27.22364 ? 186 ILE A CA  1 
ATOM   1159 C C   . ILE A 1 149 ? -26.98302 -19.71913 26.92377 1.000 23.23051 ? 186 ILE A C   1 
ATOM   1160 O O   . ILE A 1 149 ? -26.11380 -20.12542 27.69448 1.000 25.43802 ? 186 ILE A O   1 
ATOM   1161 C CB  . ILE A 1 149 ? -27.59516 -17.33721 26.35937 1.000 35.90660 ? 186 ILE A CB  1 
ATOM   1162 C CG1 . ILE A 1 149 ? -26.08667 -17.09774 26.26564 1.000 27.29018 ? 186 ILE A CG1 1 
ATOM   1163 C CG2 . ILE A 1 149 ? -28.30658 -16.09457 26.86809 1.000 19.59174 ? 186 ILE A CG2 1 
ATOM   1164 C CD1 . ILE A 1 149 ? -25.68420 -16.16225 25.15126 1.000 39.45534 ? 186 ILE A CD1 1 
ATOM   1165 N N   . ASP A 1 150 ? -27.19637 -20.26296 25.73069 1.000 32.94999 ? 187 ASP A N   1 
ATOM   1166 C CA  . ASP A 1 150 ? -26.36961 -21.34188 25.20386 1.000 34.01616 ? 187 ASP A CA  1 
ATOM   1167 C C   . ASP A 1 150 ? -25.23074 -20.71959 24.40308 1.000 26.43176 ? 187 ASP A C   1 
ATOM   1168 O O   . ASP A 1 150 ? -25.44591 -20.20828 23.30002 1.000 30.29738 ? 187 ASP A O   1 
ATOM   1169 C CB  . ASP A 1 150 ? -27.20986 -22.28508 24.34639 1.000 36.66432 ? 187 ASP A CB  1 
ATOM   1170 C CG  . ASP A 1 150 ? -26.40700 -23.44236 23.78365 1.000 34.73943 ? 187 ASP A CG  1 
ATOM   1171 O OD1 . ASP A 1 150 ? -25.25605 -23.65465 24.22378 1.000 36.04024 ? 187 ASP A OD1 1 
ATOM   1172 O OD2 . ASP A 1 150 ? -26.93418 -24.14215 22.89388 1.000 40.53352 ? 187 ASP A OD2 1 
ATOM   1173 N N   . LEU A 1 151 ? -24.01708 -20.76182 24.95950 1.000 31.15455 ? 188 LEU A N   1 
ATOM   1174 C CA  . LEU A 1 151 ? -22.86713 -20.16729 24.28649 1.000 27.39170 ? 188 LEU A CA  1 
ATOM   1175 C C   . LEU A 1 151 ? -22.54609 -20.85068 22.96462 1.000 38.01128 ? 188 LEU A C   1 
ATOM   1176 O O   . LEU A 1 151 ? -21.86034 -20.25620 22.12593 1.000 32.64335 ? 188 LEU A O   1 
ATOM   1177 C CB  . LEU A 1 151 ? -21.64126 -20.20703 25.20022 1.000 27.46780 ? 188 LEU A CB  1 
ATOM   1178 C CG  . LEU A 1 151 ? -21.63193 -19.18574 26.33704 1.000 32.29846 ? 188 LEU A CG  1 
ATOM   1179 C CD1 . LEU A 1 151 ? -20.38881 -19.34677 27.19597 1.000 27.74325 ? 188 LEU A CD1 1 
ATOM   1180 C CD2 . LEU A 1 151 ? -21.72153 -17.77425 25.77442 1.000 20.46416 ? 188 LEU A CD2 1 
ATOM   1181 N N   . ALA A 1 152 ? -23.02275 -22.08092 22.75791 1.000 31.11153 ? 189 ALA A N   1 
ATOM   1182 C CA  . ALA A 1 152 ? -22.76540 -22.77898 21.50473 1.000 31.45817 ? 189 ALA A CA  1 
ATOM   1183 C C   . ALA A 1 152 ? -23.49189 -22.14617 20.32716 1.000 24.98855 ? 189 ALA A C   1 
ATOM   1184 O O   . ALA A 1 152 ? -23.07950 -22.35032 19.18141 1.000 39.92952 ? 189 ALA A O   1 
ATOM   1185 C CB  . ALA A 1 152 ? -23.16398 -24.24926 21.62626 1.000 37.96658 ? 189 ALA A CB  1 
ATOM   1186 N N   . LYS A 1 153 ? -24.56189 -21.39394 20.57795 1.000 26.98832 ? 190 LYS A N   1 
ATOM   1187 C CA  . LYS A 1 153 ? -25.30533 -20.71243 19.52675 1.000 28.65102 ? 190 LYS A CA  1 
ATOM   1188 C C   . LYS A 1 153 ? -25.13574 -19.20038 19.58717 1.000 23.70799 ? 190 LYS A C   1 
ATOM   1189 O O   . LYS A 1 153 ? -25.86407 -18.47258 18.90166 1.000 21.64448 ? 190 LYS A O   1 
ATOM   1190 C CB  . LYS A 1 153 ? -26.79051 -21.08751 19.59824 1.000 26.66590 ? 190 LYS A CB  1 
ATOM   1191 C CG  . LYS A 1 153 ? -27.43968 -20.91483 20.97159 1.000 65.45460 ? 190 LYS A CG  1 
ATOM   1192 C CD  . LYS A 1 153 ? -27.94740 -19.49178 21.20449 1.000 74.77291 ? 190 LYS A CD  1 
ATOM   1193 C CE  . LYS A 1 153 ? -28.46587 -19.30276 22.62330 1.000 64.35960 ? 190 LYS A CE  1 
ATOM   1194 N NZ  . LYS A 1 153 ? -28.80727 -17.88007 22.90093 1.000 50.23843 ? 190 LYS A NZ  1 
ATOM   1195 N N   . ALA A 1 154 ? -24.19922 -18.71166 20.39314 1.000 19.34071 ? 191 ALA A N   1 
ATOM   1196 C CA  . ALA A 1 154 ? -24.01248 -17.27663 20.53412 1.000 18.84394 ? 191 ALA A CA  1 
ATOM   1197 C C   . ALA A 1 154 ? -23.38680 -16.68906 19.27683 1.000 24.11694 ? 191 ALA A C   1 
ATOM   1198 O O   . ALA A 1 154 ? -22.52258 -17.30399 18.64440 1.000 16.91866 ? 191 ALA A O   1 
ATOM   1199 C CB  . ALA A 1 154 ? -23.13401 -16.97246 21.74666 1.000 18.99065 ? 191 ALA A CB  1 
ATOM   1200 N N   . SER A 1 155 ? -23.84556 -15.49811 18.90427 1.000 13.28463 ? 192 SER A N   1 
ATOM   1201 C CA  . SER A 1 155 ? -23.15616 -14.73238 17.88229 1.000 20.61662 ? 192 SER A CA  1 
ATOM   1202 C C   . SER A 1 155 ? -21.85718 -14.16978 18.45275 1.000 15.14278 ? 192 SER A C   1 
ATOM   1203 O O   . SER A 1 155 ? -21.68921 -14.03542 19.66771 1.000 12.32436 ? 192 SER A O   1 
ATOM   1204 C CB  . SER A 1 155 ? -24.04746 -13.60669 17.36245 1.000 13.71057 ? 192 SER A CB  1 
ATOM   1205 O OG  . SER A 1 155 ? -25.24871 -14.12783 16.82592 1.000 27.56412 ? 192 SER A OG  1 
ATOM   1206 N N   . VAL A 1 156 ? -20.92660 -13.84775 17.55931 1.000 15.82777 ? 193 VAL A N   1 
ATOM   1207 C CA  . VAL A 1 156 ? -19.59169 -13.40128 17.93916 1.000 12.13815 ? 193 VAL A CA  1 
ATOM   1208 C C   . VAL A 1 156 ? -19.33696 -12.03355 17.32436 1.000 19.31226 ? 193 VAL A C   1 
ATOM   1209 O O   . VAL A 1 156 ? -19.60832 -11.81719 16.13724 1.000 17.65515 ? 193 VAL A O   1 
ATOM   1210 C CB  . VAL A 1 156 ? -18.51141 -14.41117 17.50936 1.000 11.47435 ? 193 VAL A CB  1 
ATOM   1211 C CG1 . VAL A 1 156 ? -17.13186 -13.76569 17.52580 1.000 13.93495 ? 193 VAL A CG1 1 
ATOM   1212 C CG2 . VAL A 1 156 ? -18.53633 -15.61856 18.43153 1.000 16.74021 ? 193 VAL A CG2 1 
ATOM   1213 N N   . MET A 1 157 ? -18.82458 -11.11673 18.13823 1.000 11.17725 ? 194 MET A N   1 
ATOM   1214 C CA  . MET A 1 157 ? -18.45574 -9.77642  17.71240 1.000 12.54324 ? 194 MET A CA  1 
ATOM   1215 C C   . MET A 1 157 ? -16.96913 -9.75852  17.37983 1.000 17.79770 ? 194 MET A C   1 
ATOM   1216 O O   . MET A 1 157 ? -16.15558 -10.31250 18.12348 1.000 17.92248 ? 194 MET A O   1 
ATOM   1217 C CB  . MET A 1 157 ? -18.77859 -8.76945  18.81941 1.000 13.37248 ? 194 MET A CB  1 
ATOM   1218 C CG  . MET A 1 157 ? -18.71140 -7.31165  18.42206 1.000 20.48409 ? 194 MET A CG  1 
ATOM   1219 S SD  . MET A 1 157 ? -19.23353 -6.25600  19.79209 1.000 22.89007 ? 194 MET A SD  1 
ATOM   1220 C CE  . MET A 1 157 ? -20.98138 -6.64723  19.89616 1.000 10.34485 ? 194 MET A CE  1 
ATOM   1221 N N   . VAL A 1 158 ? -16.61733 -9.13745  16.25388 1.000 15.62546 ? 195 VAL A N   1 
ATOM   1222 C CA  . VAL A 1 158 ? -15.25489 -9.17128  15.73164 1.000 20.36210 ? 195 VAL A CA  1 
ATOM   1223 C C   . VAL A 1 158 ? -14.78615 -7.74914  15.45196 1.000 23.31087 ? 195 VAL A C   1 
ATOM   1224 O O   . VAL A 1 158 ? -15.46044 -6.99595  14.74038 1.000 22.19374 ? 195 VAL A O   1 
ATOM   1225 C CB  . VAL A 1 158 ? -15.15310 -10.02945 14.45490 1.000 18.20567 ? 195 VAL A CB  1 
ATOM   1226 C CG1 . VAL A 1 158 ? -13.72085 -10.04044 13.93607 1.000 12.20153 ? 195 VAL A CG1 1 
ATOM   1227 C CG2 . VAL A 1 158 ? -15.63936 -11.44951 14.72199 1.000 13.82401 ? 195 VAL A CG2 1 
ATOM   1228 N N   . PHE A 1 159 ? -13.62564 -7.39153  15.99999 1.000 16.63283 ? 196 PHE A N   1 
ATOM   1229 C CA  . PHE A 1 159 ? -12.98929 -6.10131  15.76605 1.000 15.29857 ? 196 PHE A CA  1 
ATOM   1230 C C   . PHE A 1 159 ? -11.66053 -6.32763  15.05822 1.000 14.78915 ? 196 PHE A C   1 
ATOM   1231 O O   . PHE A 1 159 ? -10.81458 -7.08327  15.54768 1.000 20.39247 ? 196 PHE A O   1 
ATOM   1232 C CB  . PHE A 1 159 ? -12.76042 -5.34460  17.07910 1.000 13.85168 ? 196 PHE A CB  1 
ATOM   1233 C CG  . PHE A 1 159 ? -14.01864 -5.05561  17.84577 1.000 21.81980 ? 196 PHE A CG  1 
ATOM   1234 C CD1 . PHE A 1 159 ? -14.52490 -5.97676  18.74789 1.000 22.42781 ? 196 PHE A CD1 1 
ATOM   1235 C CD2 . PHE A 1 159 ? -14.69050 -3.85767  17.67262 1.000 25.36379 ? 196 PHE A CD2 1 
ATOM   1236 C CE1 . PHE A 1 159 ? -15.68341 -5.71037  19.45601 1.000 25.56280 ? 196 PHE A CE1 1 
ATOM   1237 C CE2 . PHE A 1 159 ? -15.84732 -3.58482  18.38064 1.000 22.45087 ? 196 PHE A CE2 1 
ATOM   1238 C CZ  . PHE A 1 159 ? -16.34317 -4.51166  19.27312 1.000 17.05645 ? 196 PHE A CZ  1 
ATOM   1239 N N   . VAL A 1 160 ? -11.47465 -5.67100  13.91682 1.000 15.60978 ? 197 VAL A N   1 
ATOM   1240 C CA  . VAL A 1 160 ? -10.28299 -5.84066  13.09245 1.000 18.48559 ? 197 VAL A CA  1 
ATOM   1241 C C   . VAL A 1 160 ? -9.48972  -4.54020  13.12023 1.000 23.14479 ? 197 VAL A C   1 
ATOM   1242 O O   . VAL A 1 160 ? -10.01156 -3.47481  12.76804 1.000 16.88150 ? 197 VAL A O   1 
ATOM   1243 C CB  . VAL A 1 160 ? -10.64142 -6.24676  11.65507 1.000 15.54177 ? 197 VAL A CB  1 
ATOM   1244 C CG1 . VAL A 1 160 ? -9.37781  -6.50243  10.84316 1.000 23.94704 ? 197 VAL A CG1 1 
ATOM   1245 C CG2 . VAL A 1 160 ? -11.52735 -7.48496  11.66593 1.000 19.79122 ? 197 VAL A CG2 1 
ATOM   1246 N N   . ASP A 1 161 ? -8.22791  -4.63437  13.53195 1.000 16.67173 ? 198 ASP A N   1 
ATOM   1247 C CA  . ASP A 1 161 ? -7.32261  -3.49684  13.68079 1.000 15.25701 ? 198 ASP A CA  1 
ATOM   1248 C C   . ASP A 1 161 ? -6.25564  -3.61028  12.59247 1.000 20.18477 ? 198 ASP A C   1 
ATOM   1249 O O   . ASP A 1 161 ? -5.24242  -4.28969  12.76316 1.000 18.52243 ? 198 ASP A O   1 
ATOM   1250 C CB  . ASP A 1 161 ? -6.71358  -3.48777  15.08774 1.000 21.34356 ? 198 ASP A CB  1 
ATOM   1251 C CG  . ASP A 1 161 ? -5.69113  -2.37932  15.29207 1.000 19.13836 ? 198 ASP A CG  1 
ATOM   1252 O OD1 . ASP A 1 161 ? -5.55860  -1.49246  14.42276 1.000 16.13764 ? 198 ASP A OD1 1 
ATOM   1253 O OD2 . ASP A 1 161 ? -5.01416  -2.39981  16.34201 1.000 20.74465 ? 198 ASP A OD2 1 
ATOM   1254 N N   . ARG A 1 162 ? -6.48888  -2.93059  11.47283 1.000 15.59726 ? 199 ARG A N   1 
ATOM   1255 C CA  . ARG A 1 162 ? -5.56520  -2.97855  10.34525 1.000 18.41007 ? 199 ARG A CA  1 
ATOM   1256 C C   . ARG A 1 162 ? -4.33034  -2.14123  10.65520 1.000 19.43014 ? 199 ARG A C   1 
ATOM   1257 O O   . ARG A 1 162 ? -4.44252  -0.94913  10.95577 1.000 15.34811 ? 199 ARG A O   1 
ATOM   1258 C CB  . ARG A 1 162 ? -6.26289  -2.47297  9.08659  1.000 18.81742 ? 199 ARG A CB  1 
ATOM   1259 C CG  . ARG A 1 162 ? -5.51430  -2.67446  7.78607  1.000 30.54318 ? 199 ARG A CG  1 
ATOM   1260 C CD  . ARG A 1 162 ? -6.40000  -2.23606  6.62745  1.000 41.53368 ? 199 ARG A CD  1 
ATOM   1261 N NE  . ARG A 1 162 ? -5.92454  -2.71592  5.33473  1.000 51.74391 ? 199 ARG A NE  1 
ATOM   1262 C CZ  . ARG A 1 162 ? -5.32324  -1.95286  4.43003  1.000 27.24654 ? 199 ARG A CZ  1 
ATOM   1263 N NH1 . ARG A 1 162 ? -5.12154  -0.66570  4.67494  1.000 59.48604 ? 199 ARG A NH1 1 
ATOM   1264 N NH2 . ARG A 1 162 ? -4.92579  -2.47752  3.27939  1.000 39.45049 ? 199 ARG A NH2 1 
ATOM   1265 N N   . LEU A 1 163 ? -3.15171  -2.76319  10.58116 1.000 12.32995 ? 200 LEU A N   1 
ATOM   1266 C CA  . LEU A 1 163 ? -1.89652  -2.10468  10.94892 1.000 16.55260 ? 200 LEU A CA  1 
ATOM   1267 C C   . LEU A 1 163 ? -1.37126  -1.29808  9.75974  1.000 18.01497 ? 200 LEU A C   1 
ATOM   1268 O O   . LEU A 1 163 ? -0.40646  -1.66093  9.08291  1.000 16.57145 ? 200 LEU A O   1 
ATOM   1269 C CB  . LEU A 1 163 ? -0.87758  -3.13023  11.42726 1.000 11.34397 ? 200 LEU A CB  1 
ATOM   1270 C CG  . LEU A 1 163 ? -1.27325  -3.91809  12.67628 1.000 14.55280 ? 200 LEU A CG  1 
ATOM   1271 C CD1 . LEU A 1 163 ? -0.17307  -4.88733  13.08510 1.000 13.37668 ? 200 LEU A CD1 1 
ATOM   1272 C CD2 . LEU A 1 163 ? -1.61258  -2.97067  13.81568 1.000 11.84596 ? 200 LEU A CD2 1 
ATOM   1273 N N   . THR A 1 164 ? -2.03423  -0.17067  9.51689  1.000 13.35470 ? 201 THR A N   1 
ATOM   1274 C CA  . THR A 1 164 ? -1.64861  0.71547   8.43448  1.000 19.29331 ? 201 THR A CA  1 
ATOM   1275 C C   . THR A 1 164 ? -0.26866  1.31343   8.70646  1.000 20.66326 ? 201 THR A C   1 
ATOM   1276 O O   . THR A 1 164 ? 0.22109   1.27673   9.83840  1.000 16.80414 ? 201 THR A O   1 
ATOM   1277 C CB  . THR A 1 164 ? -2.68449  1.82559   8.26965  1.000 16.54532 ? 201 THR A CB  1 
ATOM   1278 O OG1 . THR A 1 164 ? -2.66526  2.67284   9.42522  1.000 18.29081 ? 201 THR A OG1 1 
ATOM   1279 C CG2 . THR A 1 164 ? -4.08095  1.22824   8.10050  1.000 13.12016 ? 201 THR A CG2 1 
ATOM   1280 N N   . PRO A 1 165 ? 0.39238   1.84944   7.67357  1.000 31.05193 ? 202 PRO A N   1 
ATOM   1281 C CA  . PRO A 1 165 ? 1.68067   2.52501   7.91169  1.000 18.34802 ? 202 PRO A CA  1 
ATOM   1282 C C   . PRO A 1 165 ? 1.61295   3.60337   8.98303  1.000 24.61018 ? 202 PRO A C   1 
ATOM   1283 O O   . PRO A 1 165 ? 2.53612   3.71743   9.79971  1.000 20.58731 ? 202 PRO A O   1 
ATOM   1284 C CB  . PRO A 1 165 ? 2.02058   3.10435   6.53269  1.000 22.42330 ? 202 PRO A CB  1 
ATOM   1285 C CG  . PRO A 1 165 ? 1.37539   2.16378   5.57276  1.000 22.98322 ? 202 PRO A CG  1 
ATOM   1286 C CD  . PRO A 1 165 ? 0.09603   1.71755   6.23352  1.000 18.17824 ? 202 PRO A CD  1 
ATOM   1287 N N   . ALA A 1 166 ? 0.53422   4.39001   9.01314  1.000 20.69748 ? 203 ALA A N   1 
ATOM   1288 C CA  . ALA A 1 166 ? 0.40071   5.41782   10.04070 1.000 22.12790 ? 203 ALA A CA  1 
ATOM   1289 C C   . ALA A 1 166 ? 0.26402   4.80194   11.42743 1.000 19.32262 ? 203 ALA A C   1 
ATOM   1290 O O   . ALA A 1 166 ? 0.83398   5.31452   12.39769 1.000 28.00581 ? 203 ALA A O   1 
ATOM   1291 C CB  . ALA A 1 166 ? -0.79508  6.31968   9.73391  1.000 16.36189 ? 203 ALA A CB  1 
ATOM   1292 N N   . LYS A 1 167 ? -0.48728  3.70364   11.54371 1.000 22.59958 ? 204 LYS A N   1 
ATOM   1293 C CA  . LYS A 1 167 ? -0.63392  3.05069   12.84130 1.000 19.80131 ? 204 LYS A CA  1 
ATOM   1294 C C   . LYS A 1 167 ? 0.68903   2.47238   13.32453 1.000 19.00760 ? 204 LYS A C   1 
ATOM   1295 O O   . LYS A 1 167 ? 1.03291   2.60243   14.50500 1.000 23.74340 ? 204 LYS A O   1 
ATOM   1296 C CB  . LYS A 1 167 ? -1.69511  1.95552   12.76983 1.000 18.83111 ? 204 LYS A CB  1 
ATOM   1297 C CG  . LYS A 1 167 ? -3.12222  2.46234   12.76328 1.000 16.06159 ? 204 LYS A CG  1 
ATOM   1298 C CD  . LYS A 1 167 ? -4.07121  1.31503   13.02296 1.000 14.09769 ? 204 LYS A CD  1 
ATOM   1299 C CE  . LYS A 1 167 ? -5.51516  1.71118   12.82856 1.000 19.87026 ? 204 LYS A CE  1 
ATOM   1300 N NZ  . LYS A 1 167 ? -6.37867  0.50013   12.76967 1.000 14.30768 ? 204 LYS A NZ  1 
ATOM   1301 N N   . LEU A 1 168 ? 1.43947   1.82057   12.43156 1.000 19.80039 ? 205 LEU A N   1 
ATOM   1302 C CA  . LEU A 1 168 ? 2.74314   1.29029   12.81646 1.000 24.41688 ? 205 LEU A CA  1 
ATOM   1303 C C   . LEU A 1 168 ? 3.71073   2.40653   13.17997 1.000 30.24734 ? 205 LEU A C   1 
ATOM   1304 O O   . LEU A 1 168 ? 4.54083   2.23893   14.08199 1.000 31.06195 ? 205 LEU A O   1 
ATOM   1305 C CB  . LEU A 1 168 ? 3.31965   0.42967   11.69058 1.000 19.55520 ? 205 LEU A CB  1 
ATOM   1306 C CG  . LEU A 1 168 ? 2.55382   -0.85900  11.38409 1.000 22.78427 ? 205 LEU A CG  1 
ATOM   1307 C CD1 . LEU A 1 168 ? 3.14091   -1.56680  10.17590 1.000 16.87635 ? 205 LEU A CD1 1 
ATOM   1308 C CD2 . LEU A 1 168 ? 2.54377   -1.78109  12.59734 1.000 13.90700 ? 205 LEU A CD2 1 
ATOM   1309 N N   . ALA A 1 169 ? 3.61574   3.55102   12.49758 1.000 25.16754 ? 206 ALA A N   1 
ATOM   1310 C CA  . ALA A 1 169 ? 4.47716   4.68194   12.82570 1.000 26.81959 ? 206 ALA A CA  1 
ATOM   1311 C C   . ALA A 1 169 ? 4.17499   5.21854   14.21875 1.000 25.22144 ? 206 ALA A C   1 
ATOM   1312 O O   . ALA A 1 169 ? 5.09478   5.53328   14.98251 1.000 25.61072 ? 206 ALA A O   1 
ATOM   1313 C CB  . ALA A 1 169 ? 4.31857   5.78374   11.77859 1.000 22.28196 ? 206 ALA A CB  1 
ATOM   1314 N N   . LYS A 1 170 ? 2.89214   5.32226   14.56991 1.000 23.89188 ? 207 LYS A N   1 
ATOM   1315 C CA  . LYS A 1 170 ? 2.52615   5.81400   15.89396 1.000 26.04862 ? 207 LYS A CA  1 
ATOM   1316 C C   . LYS A 1 170 ? 2.77653   4.75827   16.96421 1.000 30.73449 ? 207 LYS A C   1 
ATOM   1317 O O   . LYS A 1 170 ? 3.21040   5.08494   18.07532 1.000 24.17513 ? 207 LYS A O   1 
ATOM   1318 C CB  . LYS A 1 170 ? 1.06132   6.25262   15.90009 1.000 23.15205 ? 207 LYS A CB  1 
ATOM   1319 C CG  . LYS A 1 170 ? 0.67903   7.16184   17.05742 1.000 30.48643 ? 207 LYS A CG  1 
ATOM   1320 C CD  . LYS A 1 170 ? 0.07139   6.38576   18.21263 1.000 39.02352 ? 207 LYS A CD  1 
ATOM   1321 C CE  . LYS A 1 170 ? -0.38333  7.32573   19.31723 1.000 45.97301 ? 207 LYS A CE  1 
ATOM   1322 N NZ  . LYS A 1 170 ? -1.05188  6.59432   20.42394 1.000 44.98479 ? 207 LYS A NZ  1 
ATOM   1323 N N   . LEU A 1 171 ? 2.50413   3.48790   16.65126 1.000 21.71046 ? 208 LEU A N   1 
ATOM   1324 C CA  . LEU A 1 171 ? 2.72460   2.42394   17.62577 1.000 20.41155 ? 208 LEU A CA  1 
ATOM   1325 C C   . LEU A 1 171 ? 4.20453   2.27193   17.95048 1.000 26.68318 ? 208 LEU A C   1 
ATOM   1326 O O   . LEU A 1 171 ? 4.57659   2.12285   19.12073 1.000 25.33056 ? 208 LEU A O   1 
ATOM   1327 C CB  . LEU A 1 171 ? 2.15202   1.10647   17.10556 1.000 17.17297 ? 208 LEU A CB  1 
ATOM   1328 C CG  . LEU A 1 171 ? 2.45756   -0.12588  17.95558 1.000 24.36945 ? 208 LEU A CG  1 
ATOM   1329 C CD1 . LEU A 1 171 ? 1.78643   -0.01081  19.31661 1.000 18.35626 ? 208 LEU A CD1 1 
ATOM   1330 C CD2 . LEU A 1 171 ? 2.03263   -1.40084  17.23770 1.000 19.34589 ? 208 LEU A CD2 1 
ATOM   1331 N N   . GLY A 1 172 ? 5.06245   2.30758   16.92905 1.000 15.82884 ? 209 GLY A N   1 
ATOM   1332 C CA  . GLY A 1 172 ? 6.49199   2.22988   17.17877 1.000 29.36604 ? 209 GLY A CA  1 
ATOM   1333 C C   . GLY A 1 172 ? 7.00532   3.41112   17.97772 1.000 33.21805 ? 209 GLY A C   1 
ATOM   1334 O O   . GLY A 1 172 ? 7.85815   3.25652   18.85497 1.000 30.76339 ? 209 GLY A O   1 
ATOM   1335 N N   . GLY A 1 173 ? 6.49481   4.60890   17.68461 1.000 27.38160 ? 210 GLY A N   1 
ATOM   1336 C CA  . GLY A 1 173 ? 6.87272   5.77335   18.46486 1.000 20.40365 ? 210 GLY A CA  1 
ATOM   1337 C C   . GLY A 1 173 ? 6.43557   5.67476   19.91182 1.000 26.20989 ? 210 GLY A C   1 
ATOM   1338 O O   . GLY A 1 173 ? 7.13883   6.14408   20.81086 1.000 32.59854 ? 210 GLY A O   1 
ATOM   1339 N N   . ASP A 1 174 ? 5.27406   5.06220   20.15984 1.000 18.67175 ? 211 ASP A N   1 
ATOM   1340 C CA  . ASP A 1 174 ? 4.81118   4.86204   21.52815 1.000 22.79047 ? 211 ASP A CA  1 
ATOM   1341 C C   . ASP A 1 174 ? 5.70157   3.90511   22.30804 1.000 29.72507 ? 211 ASP A C   1 
ATOM   1342 O O   . ASP A 1 174 ? 5.59831   3.84905   23.53876 1.000 27.46536 ? 211 ASP A O   1 
ATOM   1343 C CB  . ASP A 1 174 ? 3.37433   4.33749   21.53379 1.000 28.52958 ? 211 ASP A CB  1 
ATOM   1344 C CG  . ASP A 1 174 ? 2.36556   5.39250   21.12971 1.000 31.28401 ? 211 ASP A CG  1 
ATOM   1345 O OD1 . ASP A 1 174 ? 2.77502   6.54225   20.86533 1.000 48.05593 ? 211 ASP A OD1 1 
ATOM   1346 O OD2 . ASP A 1 174 ? 1.16075   5.07023   21.07821 1.000 34.91216 ? 211 ASP A OD2 1 
ATOM   1347 N N   . TYR A 1 175 ? 6.56484   3.14808   21.62117 1.000 17.83997 ? 212 TYR A N   1 
ATOM   1348 C CA  . TYR A 1 175 ? 7.44986   2.18588   22.26672 1.000 25.32975 ? 212 TYR A CA  1 
ATOM   1349 C C   . TYR A 1 175 ? 8.91075   2.41335   21.89215 1.000 24.48538 ? 212 TYR A C   1 
ATOM   1350 O O   . TYR A 1 175 ? 9.73177   1.50296   22.04470 1.000 24.26586 ? 212 TYR A O   1 
ATOM   1351 C CB  . TYR A 1 175 ? 7.02721   0.75419   21.92860 1.000 25.66373 ? 212 TYR A CB  1 
ATOM   1352 C CG  . TYR A 1 175 ? 5.78140   0.31020   22.65996 1.000 24.15522 ? 212 TYR A CG  1 
ATOM   1353 C CD1 . TYR A 1 175 ? 4.51981   0.70020   22.22726 1.000 20.76518 ? 212 TYR A CD1 1 
ATOM   1354 C CD2 . TYR A 1 175 ? 5.86736   -0.49239  23.79010 1.000 25.98248 ? 212 TYR A CD2 1 
ATOM   1355 C CE1 . TYR A 1 175 ? 3.37864   0.29937   22.89873 1.000 21.34186 ? 212 TYR A CE1 1 
ATOM   1356 C CE2 . TYR A 1 175 ? 4.73287   -0.89840  24.46735 1.000 19.71363 ? 212 TYR A CE2 1 
ATOM   1357 C CZ  . TYR A 1 175 ? 3.49279   -0.50034  24.01906 1.000 27.11076 ? 212 TYR A CZ  1 
ATOM   1358 O OH  . TYR A 1 175 ? 2.36467   -0.90563  24.69539 1.000 25.00291 ? 212 TYR A OH  1 
ATOM   1359 N N   . GLY A 1 176 ? 9.24808   3.60662   21.40689 1.000 19.45104 ? 213 GLY A N   1 
ATOM   1360 C CA  . GLY A 1 176 ? 10.63215  3.96457   21.15544 1.000 16.31058 ? 213 GLY A CA  1 
ATOM   1361 C C   . GLY A 1 176 ? 11.32517  3.15742   20.08260 1.000 18.77633 ? 213 GLY A C   1 
ATOM   1362 O O   . GLY A 1 176 ? 12.53981  2.94878   20.16357 1.000 23.43771 ? 213 GLY A O   1 
ATOM   1363 N N   . ILE A 1 177 ? 10.59189  2.70414   19.07079 1.000 24.01853 ? 214 ILE A N   1 
ATOM   1364 C CA  . ILE A 1 177 ? 11.13744  1.86989   18.00686 1.000 19.34985 ? 214 ILE A CA  1 
ATOM   1365 C C   . ILE A 1 177 ? 11.22493  2.70483   16.73885 1.000 24.57346 ? 214 ILE A C   1 
ATOM   1366 O O   . ILE A 1 177 ? 10.27357  3.41256   16.38741 1.000 23.40108 ? 214 ILE A O   1 
ATOM   1367 C CB  . ILE A 1 177 ? 10.28178  0.61059   17.79135 1.000 24.61439 ? 214 ILE A CB  1 
ATOM   1368 C CG1 . ILE A 1 177 ? 10.36116  -0.28792  19.02612 1.000 24.50615 ? 214 ILE A CG1 1 
ATOM   1369 C CG2 . ILE A 1 177 ? 10.72969  -0.14066  16.54690 1.000 22.71026 ? 214 ILE A CG2 1 
ATOM   1370 C CD1 . ILE A 1 177 ? 9.04295   -0.90892  19.41097 1.000 31.37786 ? 214 ILE A CD1 1 
ATOM   1371 N N   . ALA A 1 178 ? 12.36331  2.61947   16.05444 1.000 29.33987 ? 215 ALA A N   1 
ATOM   1372 C CA  . ALA A 1 178 ? 12.63583  3.44113   14.88229 1.000 32.43953 ? 215 ALA A CA  1 
ATOM   1373 C C   . ALA A 1 178 ? 12.07661  2.77905   13.62725 1.000 28.63653 ? 215 ALA A C   1 
ATOM   1374 O O   . ALA A 1 178 ? 12.46485  1.65592   13.28416 1.000 23.42186 ? 215 ALA A O   1 
ATOM   1375 C CB  . ALA A 1 178 ? 14.13840  3.67771   14.73524 1.000 27.83585 ? 215 ALA A CB  1 
ATOM   1376 N N   . ASN A 1 179 ? 11.16846  3.48114   12.94726 1.000 24.07711 ? 216 ASN A N   1 
ATOM   1377 C CA  . ASN A 1 179 ? 10.68875  3.10889   11.61560 1.000 29.45357 ? 216 ASN A CA  1 
ATOM   1378 C C   . ASN A 1 179 ? 10.04541  1.71899   11.61553 1.000 35.34717 ? 216 ASN A C   1 
ATOM   1379 O O   . ASN A 1 179 ? 10.43876  0.81580   10.87261 1.000 23.84249 ? 216 ASN A O   1 
ATOM   1380 C CB  . ASN A 1 179 ? 11.82415  3.19259   10.58683 1.000 24.61577 ? 216 ASN A CB  1 
ATOM   1381 C CG  . ASN A 1 179 ? 11.32793  3.06360   9.15557  1.000 35.39109 ? 216 ASN A CG  1 
ATOM   1382 O OD1 . ASN A 1 179 ? 10.18105  3.39507   8.85071  1.000 53.11504 ? 216 ASN A OD1 1 
ATOM   1383 N ND2 . ASN A 1 179 ? 12.18991  2.57388   8.27179  1.000 49.22102 ? 216 ASN A ND2 1 
ATOM   1384 N N   . LEU A 1 180 ? 9.03658   1.55925   12.46575 1.000 18.43016 ? 217 LEU A N   1 
ATOM   1385 C CA  . LEU A 1 180 ? 8.24596   0.33627   12.44434 1.000 22.32012 ? 217 LEU A CA  1 
ATOM   1386 C C   . LEU A 1 180 ? 7.36307   0.34061   11.20251 1.000 22.31870 ? 217 LEU A C   1 
ATOM   1387 O O   . LEU A 1 180 ? 6.60376   1.28979   10.97803 1.000 23.29150 ? 217 LEU A O   1 
ATOM   1388 C CB  . LEU A 1 180 ? 7.40374   0.21929   13.71269 1.000 16.41087 ? 217 LEU A CB  1 
ATOM   1389 C CG  . LEU A 1 180 ? 6.57520   -1.06105  13.83527 1.000 19.52816 ? 217 LEU A CG  1 
ATOM   1390 C CD1 . LEU A 1 180 ? 7.47149   -2.29311  13.74898 1.000 18.78678 ? 217 LEU A CD1 1 
ATOM   1391 C CD2 . LEU A 1 180 ? 5.77555   -1.06307  15.12764 1.000 18.00030 ? 217 LEU A CD2 1 
ATOM   1392 N N   . HIS A 1 181 ? 7.46757   -0.70821  10.38887 1.000 16.18572 ? 218 HIS A N   1 
ATOM   1393 C CA  . HIS A 1 181 ? 6.74109   -0.75568  9.12858  1.000 18.21561 ? 218 HIS A CA  1 
ATOM   1394 C C   . HIS A 1 181 ? 6.52210   -2.20275  8.71302  1.000 25.45111 ? 218 HIS A C   1 
ATOM   1395 O O   . HIS A 1 181 ? 7.12906   -3.13212  9.25302  1.000 22.85102 ? 218 HIS A O   1 
ATOM   1396 C CB  . HIS A 1 181 ? 7.48781   0.00176   8.02392  1.000 23.45536 ? 218 HIS A CB  1 
ATOM   1397 C CG  . HIS A 1 181 ? 8.77931   -0.64030  7.61870  1.000 27.05463 ? 218 HIS A CG  1 
ATOM   1398 N ND1 . HIS A 1 181 ? 9.96147   -0.42792  8.29548  1.000 24.28585 ? 218 HIS A ND1 1 
ATOM   1399 C CD2 . HIS A 1 181 ? 9.07378   -1.48961  6.60550  1.000 23.94191 ? 218 HIS A CD2 1 
ATOM   1400 C CE1 . HIS A 1 181 ? 10.92793  -1.11923  7.71738  1.000 34.48108 ? 218 HIS A CE1 1 
ATOM   1401 N NE2 . HIS A 1 181 ? 10.41606  -1.77173  6.68932  1.000 26.90107 ? 218 HIS A NE2 1 
ATOM   1402 N N   . LEU A 1 182 ? 5.64153   -2.37734  7.73131  1.000 18.68891 ? 219 LEU A N   1 
ATOM   1403 C CA  . LEU A 1 182 ? 5.42786   -3.67341  7.10335  1.000 20.46973 ? 219 LEU A CA  1 
ATOM   1404 C C   . LEU A 1 182 ? 6.57052   -3.95031  6.13505  1.000 26.65374 ? 219 LEU A C   1 
ATOM   1405 O O   . LEU A 1 182 ? 6.81361   -3.16345  5.21328  1.000 25.39055 ? 219 LEU A O   1 
ATOM   1406 C CB  . LEU A 1 182 ? 4.08408   -3.69565  6.37742  1.000 18.84923 ? 219 LEU A CB  1 
ATOM   1407 C CG  . LEU A 1 182 ? 3.77951   -4.92574  5.51928  1.000 27.92102 ? 219 LEU A CG  1 
ATOM   1408 C CD1 . LEU A 1 182 ? 3.69625   -6.18565  6.37570  1.000 18.82933 ? 219 LEU A CD1 1 
ATOM   1409 C CD2 . LEU A 1 182 ? 2.49536   -4.71859  4.72385  1.000 17.93101 ? 219 LEU A CD2 1 
ATOM   1410 N N   . LEU A 1 183 ? 7.27643   -5.05806  6.34742  1.000 31.84621 ? 220 LEU A N   1 
ATOM   1411 C CA  . LEU A 1 183 ? 8.39272   -5.40451  5.47867  1.000 25.14411 ? 220 LEU A CA  1 
ATOM   1412 C C   . LEU A 1 183 ? 7.89410   -5.67664  4.06588  1.000 22.27527 ? 220 LEU A C   1 
ATOM   1413 O O   . LEU A 1 183 ? 7.00150   -6.50311  3.85663  1.000 26.45024 ? 220 LEU A O   1 
ATOM   1414 C CB  . LEU A 1 183 ? 9.13362   -6.62555  6.02740  1.000 21.06906 ? 220 LEU A CB  1 
ATOM   1415 C CG  . LEU A 1 183 ? 10.36967  -7.09412  5.25110  1.000 29.97204 ? 220 LEU A CG  1 
ATOM   1416 C CD1 . LEU A 1 183 ? 11.45110  -6.02084  5.24587  1.000 15.80058 ? 220 LEU A CD1 1 
ATOM   1417 C CD2 . LEU A 1 183 ? 10.90997  -8.39710  5.82659  1.000 14.96569 ? 220 LEU A CD2 1 
ATOM   1418 N N   . ALA A 1 184 ? 8.46980   -4.97231  3.09730  1.000 37.35571 ? 221 ALA A N   1 
ATOM   1419 C CA  . ALA A 1 184 ? 8.10168   -5.15054  1.69724  1.000 48.36992 ? 221 ALA A CA  1 
ATOM   1420 C C   . ALA A 1 184 ? 8.88550   -6.29970  1.07104  1.000 54.98682 ? 221 ALA A C   1 
ATOM   1421 O O   . ALA A 1 184 ? 10.10022  -6.40352  1.24697  1.000 53.03937 ? 221 ALA A O   1 
ATOM   1422 C CB  . ALA A 1 184 ? 8.33273   -3.86397  0.91989  1.000 47.13776 ? 221 ALA A CB  1 
ATOM   1423 N N   . ASP A 1 190 ? 20.26847  -3.16304  6.27789  1.000 66.93121 ? 227 ASP A N   1 
ATOM   1424 C CA  . ASP A 1 190 ? 19.51509  -4.30087  6.78873  1.000 60.74837 ? 227 ASP A CA  1 
ATOM   1425 C C   . ASP A 1 190 ? 18.67595  -3.88141  7.99397  1.000 63.41847 ? 227 ASP A C   1 
ATOM   1426 O O   . ASP A 1 190 ? 18.95708  -2.86783  8.63369  1.000 59.37066 ? 227 ASP A O   1 
ATOM   1427 C CB  . ASP A 1 190 ? 20.45822  -5.44536  7.16259  1.000 66.39819 ? 227 ASP A CB  1 
ATOM   1428 C CG  . ASP A 1 190 ? 19.80387  -6.80667  7.02887  1.000 80.69198 ? 227 ASP A CG  1 
ATOM   1429 O OD1 . ASP A 1 190 ? 18.66639  -6.87336  6.51549  1.000 68.34600 ? 227 ASP A OD1 1 
ATOM   1430 O OD2 . ASP A 1 190 ? 20.42799  -7.80993  7.43525  1.000 85.88710 ? 227 ASP A OD2 1 
ATOM   1431 N N   . LYS A 1 191 ? 17.64334  -4.66376  8.30100  1.000 55.75888 ? 228 LYS A N   1 
ATOM   1432 C CA  . LYS A 1 191 ? 16.69712  -4.31479  9.34964  1.000 47.95567 ? 228 LYS A CA  1 
ATOM   1433 C C   . LYS A 1 191 ? 16.36697  -5.54811  10.17722 1.000 29.26620 ? 228 LYS A C   1 
ATOM   1434 O O   . LYS A 1 191 ? 16.62927  -6.68346  9.77322  1.000 33.53157 ? 228 LYS A O   1 
ATOM   1435 C CB  . LYS A 1 191 ? 15.40792  -3.71741  8.76423  1.000 42.70544 ? 228 LYS A CB  1 
ATOM   1436 C CG  . LYS A 1 191 ? 15.61803  -2.43411  7.97938  1.000 52.93017 ? 228 LYS A CG  1 
ATOM   1437 C CD  . LYS A 1 191 ? 14.35946  -2.01731  7.24297  1.000 43.67194 ? 228 LYS A CD  1 
ATOM   1438 C CE  . LYS A 1 191 ? 14.59379  -0.74581  6.44329  1.000 57.18122 ? 228 LYS A CE  1 
ATOM   1439 N NZ  . LYS A 1 191 ? 13.37273  -0.31690  5.70666  1.000 87.89945 ? 228 LYS A NZ  1 
ATOM   1440 N N   . GLU A 1 192 ? 15.78952  -5.30748  11.35138 1.000 26.41691 ? 229 GLU A N   1 
ATOM   1441 C CA  . GLU A 1 192 ? 15.23402  -6.38360  12.15516 1.000 31.26240 ? 229 GLU A CA  1 
ATOM   1442 C C   . GLU A 1 192 ? 13.81080  -6.69493  11.70045 1.000 24.91231 ? 229 GLU A C   1 
ATOM   1443 O O   . GLU A 1 192 ? 13.14167  -5.87528  11.06687 1.000 23.31573 ? 229 GLU A O   1 
ATOM   1444 C CB  . GLU A 1 192 ? 15.24550  -6.01542  13.63766 1.000 24.92942 ? 229 GLU A CB  1 
ATOM   1445 C CG  . GLU A 1 192 ? 16.63433  -5.90691  14.23751 1.000 35.57755 ? 229 GLU A CG  1 
ATOM   1446 C CD  . GLU A 1 192 ? 17.48727  -7.12335  13.94054 1.000 37.79560 ? 229 GLU A CD  1 
ATOM   1447 O OE1 . GLU A 1 192 ? 18.59241  -6.95222  13.38447 1.000 50.90358 ? 229 GLU A OE1 1 
ATOM   1448 O OE2 . GLU A 1 192 ? 17.04802  -8.25026  14.25285 1.000 25.13665 ? 229 GLU A OE2 1 
ATOM   1449 N N   . SER A 1 193 ? 13.34685  -7.89750  12.03248 1.000 31.51373 ? 230 SER A N   1 
ATOM   1450 C CA  . SER A 1 193 ? 12.04297  -8.33216  11.55269 1.000 24.07144 ? 230 SER A CA  1 
ATOM   1451 C C   . SER A 1 193 ? 11.50255  -9.44210  12.44113 1.000 21.65120 ? 230 SER A C   1 
ATOM   1452 O O   . SER A 1 193 ? 12.26474  -10.18874 13.06034 1.000 28.91018 ? 230 SER A O   1 
ATOM   1453 C CB  . SER A 1 193 ? 12.12199  -8.81259  10.09910 1.000 16.33819 ? 230 SER A CB  1 
ATOM   1454 O OG  . SER A 1 193 ? 10.86312  -9.26852  9.64134  1.000 56.05233 ? 230 SER A OG  1 
ATOM   1455 N N   . LEU A 1 194 ? 10.17394  -9.53293  12.49544 1.000 20.77177 ? 231 LEU A N   1 
ATOM   1456 C CA  . LEU A 1 194 ? 9.48386   -10.66067 13.10397 1.000 24.95384 ? 231 LEU A CA  1 
ATOM   1457 C C   . LEU A 1 194 ? 8.22842   -10.95878 12.29884 1.000 24.91736 ? 231 LEU A C   1 
ATOM   1458 O O   . LEU A 1 194 ? 7.64842   -10.06951 11.66928 1.000 22.37360 ? 231 LEU A O   1 
ATOM   1459 C CB  . LEU A 1 194 ? 9.12569   -10.40669 14.58316 1.000 16.27241 ? 231 LEU A CB  1 
ATOM   1460 C CG  . LEU A 1 194 ? 8.23189   -9.24328  15.03496 1.000 32.16518 ? 231 LEU A CG  1 
ATOM   1461 C CD1 . LEU A 1 194 ? 6.74668   -9.50941  14.80563 1.000 23.63421 ? 231 LEU A CD1 1 
ATOM   1462 C CD2 . LEU A 1 194 ? 8.48330   -8.94317  16.50513 1.000 27.42417 ? 231 LEU A CD2 1 
ATOM   1463 N N   . ALA A 1 195 ? 7.81226   -12.21926 12.32812 1.000 21.75847 ? 232 ALA A N   1 
ATOM   1464 C CA  . ALA A 1 195 ? 6.61482   -12.64773 11.62255 1.000 26.35140 ? 232 ALA A CA  1 
ATOM   1465 C C   . ALA A 1 195 ? 5.37938   -12.41457 12.47888 1.000 19.17573 ? 232 ALA A C   1 
ATOM   1466 O O   . ALA A 1 195 ? 5.42472   -12.53844 13.70597 1.000 19.32874 ? 232 ALA A O   1 
ATOM   1467 C CB  . ALA A 1 195 ? 6.70726   -14.12729 11.24643 1.000 24.75689 ? 232 ALA A CB  1 
ATOM   1468 N N   . LEU A 1 196 ? 4.27750   -12.05949 11.82479 1.000 19.53766 ? 233 LEU A N   1 
ATOM   1469 C CA  . LEU A 1 196 ? 2.96202   -12.09521 12.45825 1.000 19.70298 ? 233 LEU A CA  1 
ATOM   1470 C C   . LEU A 1 196 ? 2.37927   -13.46417 12.14226 1.000 19.48624 ? 233 LEU A C   1 
ATOM   1471 O O   . LEU A 1 196 ? 1.88283   -13.69897 11.03708 1.000 17.10425 ? 233 LEU A O   1 
ATOM   1472 C CB  . LEU A 1 196 ? 2.07088   -10.96177 11.96064 1.000 11.79381 ? 233 LEU A CB  1 
ATOM   1473 C CG  . LEU A 1 196 ? 2.57150   -9.53961  12.23266 1.000 26.52200 ? 233 LEU A CG  1 
ATOM   1474 C CD1 . LEU A 1 196 ? 1.50888   -8.51776  11.86505 1.000 15.68603 ? 233 LEU A CD1 1 
ATOM   1475 C CD2 . LEU A 1 196 ? 3.00172   -9.37045  13.68595 1.000 17.29000 ? 233 LEU A CD2 1 
ATOM   1476 N N   . GLU A 1 197 ? 2.47059   -14.37856 13.10789 1.000 19.20974 ? 234 GLU A N   1 
ATOM   1477 C CA  . GLU A 1 197 ? 2.06247   -15.75849 12.88067 1.000 18.47051 ? 234 GLU A CA  1 
ATOM   1478 C C   . GLU A 1 197 ? 0.60970   -15.82530 12.42989 1.000 19.26945 ? 234 GLU A C   1 
ATOM   1479 O O   . GLU A 1 197 ? -0.24427  -15.07221 12.90748 1.000 19.12438 ? 234 GLU A O   1 
ATOM   1480 C CB  . GLU A 1 197 ? 2.26284   -16.58571 14.15133 1.000 18.56926 ? 234 GLU A CB  1 
ATOM   1481 C CG  . GLU A 1 197 ? 3.70559   -16.62911 14.64300 1.000 26.24745 ? 234 GLU A CG  1 
ATOM   1482 C CD  . GLU A 1 197 ? 4.64754   -17.30621 13.65945 1.000 30.01834 ? 234 GLU A CD  1 
ATOM   1483 O OE1 . GLU A 1 197 ? 4.17302   -18.09276 12.81172 1.000 38.97144 ? 234 GLU A OE1 1 
ATOM   1484 O OE2 . GLU A 1 197 ? 5.86728   -17.05190 13.73592 1.000 35.50611 ? 234 GLU A OE2 1 
ATOM   1485 N N   . GLY A 1 198 ? 0.33694   -16.73158 11.49423 1.000 19.39808 ? 235 GLY A N   1 
ATOM   1486 C CA  . GLY A 1 198 ? -0.96651  -16.83480 10.87926 1.000 16.53905 ? 235 GLY A CA  1 
ATOM   1487 C C   . GLY A 1 198 ? -1.16845  -15.94117 9.67724  1.000 26.18090 ? 235 GLY A C   1 
ATOM   1488 O O   . GLY A 1 198 ? -2.26957  -15.93211 9.11118  1.000 24.72434 ? 235 GLY A O   1 
ATOM   1489 N N   . THR A 1 199 ? -0.15240  -15.18488 9.28026  1.000 21.57843 ? 236 THR A N   1 
ATOM   1490 C CA  . THR A 1 199 ? -0.19803  -14.27655 8.14588  1.000 25.00679 ? 236 THR A CA  1 
ATOM   1491 C C   . THR A 1 199 ? 1.08775   -14.44020 7.35282  1.000 29.32612 ? 236 THR A C   1 
ATOM   1492 O O   . THR A 1 199 ? 2.07570   -14.97723 7.86737  1.000 18.83635 ? 236 THR A O   1 
ATOM   1493 C CB  . THR A 1 199 ? -0.33717  -12.80908 8.58323  1.000 18.29656 ? 236 THR A CB  1 
ATOM   1494 O OG1 . THR A 1 199 ? 0.94544   -12.30460 8.97732  1.000 20.19193 ? 236 THR A OG1 1 
ATOM   1495 C CG2 . THR A 1 199 ? -1.29715  -12.67166 9.74812  1.000 27.45432 ? 236 THR A CG2 1 
ATOM   1496 N N   . PRO A 1 200 ? 1.10924   -13.99349 6.09541  1.000 19.04405 ? 237 PRO A N   1 
ATOM   1497 C CA  . PRO A 1 200 ? 2.37235   -13.90139 5.35724  1.000 19.25737 ? 237 PRO A CA  1 
ATOM   1498 C C   . PRO A 1 200 ? 3.16472   -12.63442 5.63399  1.000 22.95230 ? 237 PRO A C   1 
ATOM   1499 O O   . PRO A 1 200 ? 4.16376   -12.39079 4.95230  1.000 32.61632 ? 237 PRO A O   1 
ATOM   1500 C CB  . PRO A 1 200 ? 1.90566   -13.93243 3.89430  1.000 11.49487 ? 237 PRO A CB  1 
ATOM   1501 C CG  . PRO A 1 200 ? 0.59206   -13.25335 3.93306  1.000 21.85060 ? 237 PRO A CG  1 
ATOM   1502 C CD  . PRO A 1 200 ? -0.04643  -13.66896 5.23766  1.000 20.22967 ? 237 PRO A CD  1 
ATOM   1503 N N   . HIS A 1 201 ? 2.75108   -11.83141 6.60678  1.000 18.87183 ? 238 HIS A N   1 
ATOM   1504 C CA  . HIS A 1 201 ? 3.31658   -10.50955 6.81423  1.000 17.61799 ? 238 HIS A CA  1 
ATOM   1505 C C   . HIS A 1 201 ? 4.40892   -10.54083 7.87439  1.000 21.88011 ? 238 HIS A C   1 
ATOM   1506 O O   . HIS A 1 201 ? 4.38439   -11.35279 8.80299  1.000 15.00755 ? 238 HIS A O   1 
ATOM   1507 C CB  . HIS A 1 201 ? 2.22849   -9.51333  7.21976  1.000 12.46239 ? 238 HIS A CB  1 
ATOM   1508 C CG  . HIS A 1 201 ? 1.14556   -9.35276  6.19789  1.000 18.11562 ? 238 HIS A CG  1 
ATOM   1509 N ND1 . HIS A 1 201 ? 1.38591   -8.87547  4.92736  1.000 17.02102 ? 238 HIS A ND1 1 
ATOM   1510 C CD2 . HIS A 1 201 ? -0.18413  -9.60175  6.26042  1.000 18.04863 ? 238 HIS A CD2 1 
ATOM   1511 C CE1 . HIS A 1 201 ? 0.25165   -8.83761  4.25132  1.000 21.45098 ? 238 HIS A CE1 1 
ATOM   1512 N NE2 . HIS A 1 201 ? -0.71663  -9.27274  5.03719  1.000 18.32187 ? 238 HIS A NE2 1 
ATOM   1513 N N   . ARG A 1 202 ? 5.37295   -9.63874  7.72081  1.000 14.53627 ? 239 ARG A N   1 
ATOM   1514 C CA  . ARG A 1 202 ? 6.43969   -9.44967  8.69005  1.000 20.47790 ? 239 ARG A CA  1 
ATOM   1515 C C   . ARG A 1 202 ? 6.56235   -7.96450  8.98870  1.000 23.11888 ? 239 ARG A C   1 
ATOM   1516 O O   . ARG A 1 202 ? 6.54281   -7.13978  8.06926  1.000 20.09480 ? 239 ARG A O   1 
ATOM   1517 C CB  . ARG A 1 202 ? 7.77447   -9.99937  8.17103  1.000 17.05728 ? 239 ARG A CB  1 
ATOM   1518 C CG  . ARG A 1 202 ? 7.76715   -11.48858 7.85785  1.000 20.88201 ? 239 ARG A CG  1 
ATOM   1519 C CD  . ARG A 1 202 ? 9.16581   -11.98306 7.50420  1.000 20.03245 ? 239 ARG A CD  1 
ATOM   1520 N NE  . ARG A 1 202 ? 10.10951  -11.78017 8.60097  1.000 22.99760 ? 239 ARG A NE  1 
ATOM   1521 C CZ  . ARG A 1 202 ? 10.33107  -12.66482 9.56852  1.000 19.99813 ? 239 ARG A CZ  1 
ATOM   1522 N NH1 . ARG A 1 202 ? 11.20336  -12.39572 10.53017 1.000 17.02819 ? 239 ARG A NH1 1 
ATOM   1523 N NH2 . ARG A 1 202 ? 9.67980   -13.81975 9.57499  1.000 16.70305 ? 239 ARG A NH2 1 
ATOM   1524 N N   . LEU A 1 203 ? 6.67142   -7.62629  10.26799 1.000 16.66127 ? 240 LEU A N   1 
ATOM   1525 C CA  . LEU A 1 203 ? 6.96334   -6.26253  10.67696 1.000 13.47546 ? 240 LEU A CA  1 
ATOM   1526 C C   . LEU A 1 203 ? 8.47124   -6.07062  10.75277 1.000 25.50518 ? 240 LEU A C   1 
ATOM   1527 O O   . LEU A 1 203 ? 9.20235   -6.96974  11.17720 1.000 25.53432 ? 240 LEU A O   1 
ATOM   1528 C CB  . LEU A 1 203 ? 6.32179   -5.94832  12.02865 1.000 11.77446 ? 240 LEU A CB  1 
ATOM   1529 C CG  . LEU A 1 203 ? 4.79453   -5.99747  12.07788 1.000 14.64443 ? 240 LEU A CG  1 
ATOM   1530 C CD1 . LEU A 1 203 ? 4.28144   -5.45806  13.40736 1.000 13.26614 ? 240 LEU A CD1 1 
ATOM   1531 C CD2 . LEU A 1 203 ? 4.19257   -5.22729  10.90901 1.000 17.30633 ? 240 LEU A CD2 1 
ATOM   1532 N N   . ALA A 1 204 ? 8.93274   -4.89629  10.33194 1.000 27.42321 ? 241 ALA A N   1 
ATOM   1533 C CA  . ALA A 1 204 ? 10.35334  -4.59022  10.29594 1.000 21.30611 ? 241 ALA A CA  1 
ATOM   1534 C C   . ALA A 1 204 ? 10.60747  -3.23278  10.93726 1.000 23.79242 ? 241 ALA A C   1 
ATOM   1535 O O   . ALA A 1 204 ? 9.71582   -2.38522  11.02883 1.000 21.59548 ? 241 ALA A O   1 
ATOM   1536 C CB  . ALA A 1 204 ? 10.89752  -4.61112  8.85933  1.000 16.84901 ? 241 ALA A CB  1 
ATOM   1537 N N   . TRP A 1 205 ? 11.84466  -3.03943  11.38488 1.000 18.99846 ? 242 TRP A N   1 
ATOM   1538 C CA  . TRP A 1 205 ? 12.24381  -1.80240  12.04100 1.000 23.78388 ? 242 TRP A CA  1 
ATOM   1539 C C   . TRP A 1 205 ? 13.76108  -1.68891  11.97298 1.000 30.86315 ? 242 TRP A C   1 
ATOM   1540 O O   . TRP A 1 205 ? 14.45709  -2.62626  11.57581 1.000 28.28700 ? 242 TRP A O   1 
ATOM   1541 C CB  . TRP A 1 205 ? 11.74442  -1.75582  13.48746 1.000 21.50312 ? 242 TRP A CB  1 
ATOM   1542 C CG  . TRP A 1 205 ? 12.24701  -2.88418  14.33163 1.000 22.89811 ? 242 TRP A CG  1 
ATOM   1543 C CD1 . TRP A 1 205 ? 13.34848  -2.87608  15.13513 1.000 25.96221 ? 242 TRP A CD1 1 
ATOM   1544 C CD2 . TRP A 1 205 ? 11.67060  -4.19172  14.45354 1.000 21.00524 ? 242 TRP A CD2 1 
ATOM   1545 N NE1 . TRP A 1 205 ? 13.49403  -4.09505  15.75044 1.000 26.38003 ? 242 TRP A NE1 1 
ATOM   1546 C CE2 . TRP A 1 205 ? 12.47548  -4.91965  15.35187 1.000 18.69183 ? 242 TRP A CE2 1 
ATOM   1547 C CE3 . TRP A 1 205 ? 10.54971  -4.81507  13.89448 1.000 23.73491 ? 242 TRP A CE3 1 
ATOM   1548 C CZ2 . TRP A 1 205 ? 12.19832  -6.23995  15.70281 1.000 19.14658 ? 242 TRP A CZ2 1 
ATOM   1549 C CZ3 . TRP A 1 205 ? 10.27557  -6.12653  14.24266 1.000 26.85289 ? 242 TRP A CZ3 1 
ATOM   1550 C CH2 . TRP A 1 205 ? 11.09675  -6.82463  15.13864 1.000 33.18487 ? 242 TRP A CH2 1 
ATOM   1551 N N   . VAL A 1 206 ? 14.26729  -0.52615  12.36994 1.000 35.39107 ? 243 VAL A N   1 
ATOM   1552 C CA  . VAL A 1 206 ? 15.69364  -0.23015  12.28193 1.000 34.82782 ? 243 VAL A CA  1 
ATOM   1553 C C   . VAL A 1 206 ? 16.36259  -0.58541  13.60361 1.000 44.25829 ? 243 VAL A C   1 
ATOM   1554 O O   . VAL A 1 206 ? 15.96278  -0.09232  14.66473 1.000 39.92657 ? 243 VAL A O   1 
ATOM   1555 C CB  . VAL A 1 206 ? 15.93548  1.24327   11.92401 1.000 41.41782 ? 243 VAL A CB  1 
ATOM   1556 C CG1 . VAL A 1 206 ? 17.40144  1.60325   12.13184 1.000 28.45663 ? 243 VAL A CG1 1 
ATOM   1557 C CG2 . VAL A 1 206 ? 15.51454  1.51365   10.48694 1.000 35.90720 ? 243 VAL A CG2 1 
ATOM   1558 N N   . SER A 1 207 ? 17.38034  -1.44125  13.53443 1.000 53.92383 ? 244 SER A N   1 
ATOM   1559 C CA  . SER A 1 207 ? 18.22241  -1.77753  14.68155 1.000 62.34752 ? 244 SER A CA  1 
ATOM   1560 C C   . SER A 1 207 ? 19.44482  -2.56598  14.22511 1.000 49.55596 ? 244 SER A C   1 
ATOM   1561 O O   . SER A 1 207 ? 19.45304  -3.13728  13.13411 1.000 53.76973 ? 244 SER A O   1 
ATOM   1562 C CB  . SER A 1 207 ? 17.44362  -2.57773  15.72760 1.000 46.44766 ? 244 SER A CB  1 
ATOM   1563 O OG  . SER A 1 207 ? 16.54393  -1.74244  16.43453 1.000 67.19004 ? 244 SER A OG  1 
HETATM 1564 O O   . HOH B 2 .   ? -29.42985 -12.47627 21.33422 1.000 62.61558 ? 301 HOH A O   1 
HETATM 1565 O O   . HOH B 2 .   ? -2.86502  -12.38613 23.56723 1.000 49.04146 ? 302 HOH A O   1 
HETATM 1566 O O   . HOH B 2 .   ? -7.10969  2.39616   10.18214 1.000 25.12332 ? 303 HOH A O   1 
HETATM 1567 O O   . HOH B 2 .   ? -13.58531 -10.51119 30.30794 1.000 29.91324 ? 304 HOH A O   1 
HETATM 1568 O O   . HOH B 2 .   ? -23.91812 -24.69990 25.89172 1.000 39.77512 ? 305 HOH A O   1 
HETATM 1569 O O   . HOH B 2 .   ? -14.98551 9.85112   16.39965 1.000 31.05186 ? 306 HOH A O   1 
HETATM 1570 O O   . HOH B 2 .   ? -18.10289 8.46538   13.24216 1.000 27.48613 ? 307 HOH A O   1 
HETATM 1571 O O   . HOH B 2 .   ? -18.50914 -14.44393 6.90628  1.000 23.02169 ? 308 HOH A O   1 
HETATM 1572 O O   . HOH B 2 .   ? -11.87299 -13.40528 -0.57866 1.000 39.36962 ? 309 HOH A O   1 
HETATM 1573 O O   . HOH B 2 .   ? 3.44437   -8.84516  3.52117  1.000 26.08854 ? 310 HOH A O   1 
HETATM 1574 O O   . HOH B 2 .   ? -27.907   3.940     23.266   1.000 20.15948 ? 311 HOH A O   1 
HETATM 1575 O O   . HOH B 2 .   ? 11.08329  -10.95578 17.68673 1.000 39.01043 ? 312 HOH A O   1 
HETATM 1576 O O   . HOH B 2 .   ? -15.62814 -14.85914 23.76279 1.000 16.63755 ? 313 HOH A O   1 
HETATM 1577 O O   . HOH B 2 .   ? -12.07763 -16.86424 5.72894  1.000 20.90620 ? 314 HOH A O   1 
HETATM 1578 O O   . HOH B 2 .   ? -25.24580 -14.11200 20.83960 1.000 14.52060 ? 315 HOH A O   1 
HETATM 1579 O O   . HOH B 2 .   ? 4.47951   -13.89500 8.56098  1.000 20.81359 ? 316 HOH A O   1 
HETATM 1580 O O   . HOH B 2 .   ? -14.33012 -5.48707  29.38494 1.000 25.10207 ? 317 HOH A O   1 
HETATM 1581 O O   . HOH B 2 .   ? -28.62023 -6.51042  31.73426 1.000 20.84565 ? 318 HOH A O   1 
HETATM 1582 O O   . HOH B 2 .   ? 28.01252  -6.28725  27.70324 1.000 42.74935 ? 319 HOH A O   1 
HETATM 1583 O O   . HOH B 2 .   ? 27.22515  -9.45546  21.70189 1.000 30.47003 ? 320 HOH A O   1 
HETATM 1584 O O   . HOH B 2 .   ? -8.508    0.664     23.012   1.000 34.89520 ? 321 HOH A O   1 
HETATM 1585 O O   . HOH B 2 .   ? -26.63683 -16.39916 17.48143 1.000 28.09714 ? 322 HOH A O   1 
HETATM 1586 O O   . HOH B 2 .   ? -2.11722  -15.19455 14.76536 1.000 17.70359 ? 323 HOH A O   1 
HETATM 1587 O O   . HOH B 2 .   ? -4.80738  4.22438   9.63193  1.000 29.52497 ? 324 HOH A O   1 
HETATM 1588 O O   . HOH B 2 .   ? -17.63597 -11.06905 32.43863 1.000 21.60429 ? 325 HOH A O   1 
HETATM 1589 O O   . HOH B 2 .   ? -26.44658 -12.53831 15.04953 1.000 35.42033 ? 326 HOH A O   1 
HETATM 1590 O O   . HOH B 2 .   ? -20.62978 2.77873   18.42679 1.000 21.20798 ? 327 HOH A O   1 
HETATM 1591 O O   . HOH B 2 .   ? -16.45398 -3.37061  30.45408 1.000 27.80932 ? 328 HOH A O   1 
HETATM 1592 O O   . HOH B 2 .   ? 8.34916   3.41031   14.29123 1.000 25.45548 ? 329 HOH A O   1 
HETATM 1593 O O   . HOH B 2 .   ? -6.09464  -4.40667  18.10820 1.000 16.30650 ? 330 HOH A O   1 
HETATM 1594 O O   . HOH B 2 .   ? -33.89590 -0.29392  16.49778 1.000 39.94696 ? 331 HOH A O   1 
HETATM 1595 O O   . HOH B 2 .   ? 8.01917   -17.39208 12.14098 1.000 22.84697 ? 332 HOH A O   1 
HETATM 1596 O O   . HOH B 2 .   ? -20.80334 5.25418   19.23036 1.000 16.32040 ? 333 HOH A O   1 
HETATM 1597 O O   . HOH B 2 .   ? -30.23904 0.12288   27.82769 1.000 34.17528 ? 334 HOH A O   1 
HETATM 1598 O O   . HOH B 2 .   ? -23.46363 -22.03376 27.29594 1.000 32.67226 ? 335 HOH A O   1 
HETATM 1599 O O   . HOH B 2 .   ? -0.96876  2.87648   16.92928 1.000 25.01716 ? 336 HOH A O   1 
HETATM 1600 O O   . HOH B 2 .   ? -14.99525 -0.08014  10.65473 1.000 17.52219 ? 337 HOH A O   1 
HETATM 1601 O O   . HOH B 2 .   ? 5.86266   -8.68200  5.03741  1.000 24.00811 ? 338 HOH A O   1 
HETATM 1602 O O   . HOH B 2 .   ? 17.99835  0.47670   17.07148 1.000 47.17761 ? 339 HOH A O   1 
HETATM 1603 O O   . HOH B 2 .   ? -25.78603 -11.46256 38.79339 1.000 49.70016 ? 340 HOH A O   1 
HETATM 1604 O O   . HOH B 2 .   ? -5.95442  -1.58238  21.51488 1.000 24.43729 ? 341 HOH A O   1 
HETATM 1605 O O   . HOH B 2 .   ? -15.445   9.363     20.406   1.000 21.68678 ? 342 HOH A O   1 
HETATM 1606 O O   . HOH B 2 .   ? -14.55371 -24.49820 11.80468 1.000 33.26655 ? 343 HOH A O   1 
HETATM 1607 O O   . HOH B 2 .   ? -8.22340  -6.00559  17.06951 1.000 20.10589 ? 344 HOH A O   1 
HETATM 1608 O O   . HOH B 2 .   ? -21.35751 -14.12508 5.31391  1.000 31.39366 ? 345 HOH A O   1 
HETATM 1609 O O   . HOH B 2 .   ? 4.79470   2.35407   8.95960  1.000 32.06228 ? 346 HOH A O   1 
HETATM 1610 O O   . HOH B 2 .   ? 15.50310  -9.79322  12.54431 1.000 30.95909 ? 347 HOH A O   1 
HETATM 1611 O O   . HOH B 2 .   ? -6.91195  1.02980   17.16971 1.000 23.18697 ? 348 HOH A O   1 
HETATM 1612 O O   . HOH B 2 .   ? -20.90024 5.08090   16.57679 1.000 18.66609 ? 349 HOH A O   1 
HETATM 1613 O O   . HOH B 2 .   ? -9.81973  -1.29450  26.89919 1.000 39.90008 ? 350 HOH A O   1 
HETATM 1614 O O   . HOH B 2 .   ? -22.90874 5.06155   12.71634 1.000 20.61706 ? 351 HOH A O   1 
HETATM 1615 O O   . HOH B 2 .   ? -21.06503 -11.16452 1.52066  1.000 30.69554 ? 352 HOH A O   1 
HETATM 1616 O O   . HOH B 2 .   ? -21.67884 -11.47323 30.12844 1.000 26.17119 ? 353 HOH A O   1 
HETATM 1617 O O   . HOH B 2 .   ? -21.50526 -9.20935  4.98207  1.000 46.59309 ? 354 HOH A O   1 
HETATM 1618 O O   . HOH B 2 .   ? -23.98470 -4.81780  7.31066  1.000 25.20697 ? 355 HOH A O   1 
HETATM 1619 O O   . HOH B 2 .   ? -19.62095 -17.67569 30.35559 1.000 34.08346 ? 356 HOH A O   1 
HETATM 1620 O O   . HOH B 2 .   ? -8.746    -18.452   13.716   1.000 28.72297 ? 357 HOH A O   1 
HETATM 1621 O O   . HOH B 2 .   ? 1.19238   -1.36103  6.70262  1.000 25.72088 ? 358 HOH A O   1 
HETATM 1622 O O   . HOH B 2 .   ? -19.87877 -7.08852  31.01810 1.000 14.90086 ? 359 HOH A O   1 
HETATM 1623 O O   . HOH B 2 .   ? -29.10065 -15.03795 36.64639 1.000 43.59257 ? 360 HOH A O   1 
HETATM 1624 O O   . HOH B 2 .   ? -25.68634 -19.00557 15.12194 1.000 47.86961 ? 361 HOH A O   1 
HETATM 1625 O O   . HOH B 2 .   ? -10.30537 -2.52616  3.56005  1.000 45.09195 ? 362 HOH A O   1 
HETATM 1626 O O   . HOH B 2 .   ? 14.50821  0.86445   17.00616 1.000 31.56033 ? 363 HOH A O   1 
HETATM 1627 O O   . HOH B 2 .   ? -20.92189 -15.02833 33.45714 1.000 42.97259 ? 364 HOH A O   1 
HETATM 1628 O O   . HOH B 2 .   ? -4.658    -18.732   9.310    1.000 26.24309 ? 365 HOH A O   1 
HETATM 1629 O O   . HOH B 2 .   ? -14.09386 -18.52379 6.40289  1.000 28.16328 ? 366 HOH A O   1 
HETATM 1630 O O   . HOH B 2 .   ? -9.81613  -1.58275  30.32568 1.000 24.02017 ? 367 HOH A O   1 
HETATM 1631 O O   . HOH B 2 .   ? -25.655   -5.543    30.160   1.000 13.54788 ? 368 HOH A O   1 
HETATM 1632 O O   . HOH B 2 .   ? 7.68052   4.37106   10.06018 1.000 33.07542 ? 369 HOH A O   1 
HETATM 1633 O O   . HOH B 2 .   ? -21.55783 -9.78887  36.50428 1.000 32.14082 ? 370 HOH A O   1 
HETATM 1634 O O   . HOH B 2 .   ? 2.65152   -18.03466 10.19111 1.000 17.79365 ? 371 HOH A O   1 
HETATM 1635 O O   . HOH B 2 .   ? 3.97272   0.00883   7.14685  1.000 22.18385 ? 372 HOH A O   1 
HETATM 1636 O O   . HOH B 2 .   ? -9.62525  -11.54662 27.03418 1.000 22.45986 ? 373 HOH A O   1 
HETATM 1637 O O   . HOH B 2 .   ? -1.50411  4.83527   6.87249  1.000 33.50586 ? 374 HOH A O   1 
HETATM 1638 O O   . HOH B 2 .   ? -22.01645 -9.98274  34.15217 1.000 22.93215 ? 375 HOH A O   1 
HETATM 1639 O O   . HOH B 2 .   ? -24.86620 7.97103   12.70073 1.000 38.69125 ? 376 HOH A O   1 
HETATM 1640 O O   . HOH B 2 .   ? 7.31181   -15.11673 8.24305  1.000 32.06369 ? 377 HOH A O   1 
HETATM 1641 O O   . HOH B 2 .   ? 3.45331   -13.13882 15.98220 1.000 28.57855 ? 378 HOH A O   1 
HETATM 1642 O O   . HOH B 2 .   ? -7.31260  -14.46386 26.03619 1.000 39.86904 ? 379 HOH A O   1 
HETATM 1643 O O   . HOH B 2 .   ? -24.51270 -15.22412 30.04884 1.000 33.83608 ? 380 HOH A O   1 
HETATM 1644 O O   . HOH B 2 .   ? 14.76022  -2.73139  29.01593 1.000 28.67802 ? 381 HOH A O   1 
HETATM 1645 O O   . HOH B 2 .   ? -32.75511 -15.80309 25.32809 1.000 41.34981 ? 382 HOH A O   1 
HETATM 1646 O O   . HOH B 2 .   ? 15.03814  -9.18027  8.60424  1.000 36.72351 ? 383 HOH A O   1 
HETATM 1647 O O   . HOH B 2 .   ? -7.323    -20.609   9.750    1.000 31.18230 ? 384 HOH A O   1 
HETATM 1648 O O   . HOH B 2 .   ? -0.20512  -15.66549 18.78126 1.000 52.53546 ? 385 HOH A O   1 
HETATM 1649 O O   . HOH B 2 .   ? -6.57264  -0.72478  18.79426 1.000 27.26748 ? 386 HOH A O   1 
HETATM 1650 O O   . HOH B 2 .   ? 19.744    -13.253   24.987   1.000 50.61258 ? 387 HOH A O   1 
HETATM 1651 O O   . HOH B 2 .   ? -26.20230 -4.46457  6.96198  1.000 42.32314 ? 388 HOH A O   1 
HETATM 1652 O O   . HOH B 2 .   ? -9.82568  -1.47725  5.62690  1.000 29.43328 ? 389 HOH A O   1 
HETATM 1653 O O   . HOH B 2 .   ? -8.995    -18.784   15.973   1.000 31.00608 ? 390 HOH A O   1 
HETATM 1654 O O   . HOH B 2 .   ? 14.99595  -0.41702  29.76840 1.000 36.66727 ? 391 HOH A O   1 
HETATM 1655 O O   . HOH B 2 .   ? 10.01242  2.42739   5.40504  1.000 49.76895 ? 392 HOH A O   1 
HETATM 1656 O O   . HOH B 2 .   ? -9.46271  6.34356   11.22698 1.000 36.87490 ? 393 HOH A O   1 
HETATM 1657 O O   . HOH B 2 .   ? -11.14134 -9.70603  28.26990 1.000 32.70352 ? 394 HOH A O   1 
HETATM 1658 O O   . HOH B 2 .   ? 13.846    4.770     23.155   1.000 31.68037 ? 395 HOH A O   1 
HETATM 1659 O O   . HOH B 2 .   ? -22.27896 -11.80264 4.01833  1.000 32.20562 ? 396 HOH A O   1 
HETATM 1660 O O   . HOH B 2 .   ? 4.48901   -18.02552 7.42634  1.000 40.17006 ? 397 HOH A O   1 
HETATM 1661 O O   . HOH B 2 .   ? -19.28014 -15.94700 5.07880  1.000 27.98351 ? 398 HOH A O   1 
HETATM 1662 O O   . HOH B 2 .   ? 17.16248  -2.80577  30.46634 1.000 42.58652 ? 399 HOH A O   1 
HETATM 1663 O O   . HOH B 2 .   ? 4.88646   -12.18489 17.80402 1.000 47.01248 ? 400 HOH A O   1 
HETATM 1664 O O   . HOH B 2 .   ? -4.07498  5.77927   7.03310  1.000 49.17533 ? 401 HOH A O   1 
HETATM 1665 O O   . HOH B 2 .   ? -9.21630  -10.58563 29.02539 1.000 38.20295 ? 402 HOH A O   1 
HETATM 1666 O O   . HOH B 2 .   ? -15.79408 -20.01912 5.91045  1.000 41.50187 ? 403 HOH A O   1 
HETATM 1667 O O   . HOH B 2 .   ? -20.04811 -9.56278  32.04749 1.000 26.77733 ? 404 HOH A O   1 
HETATM 1668 O O   . HOH B 2 .   ? -0.06176  -2.37281  3.97753  1.000 36.12605 ? 405 HOH A O   1 
HETATM 1669 O O   . HOH B 2 .   ? 14.93519  -6.13442  27.17691 1.000 32.81967 ? 406 HOH A O   1 
# 
