data_8Z2G
# 
_entry.id   8Z2G 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8Z2G         pdb_00008z2g 10.2210/pdb8z2g/pdb 
WWPDB D_1300046810 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-06 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8Z2G 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-12 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 ito.str@tmd.ac.jp Nobutoshi Ito ? 'principal investigator/group leader' 0000-0003-0839-0384 
3 oda@kpu.ac.jp     Masayuki  Oda ? 'principal investigator/group leader' 0000-0002-8568-4223 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Numoto, N.'    1 ? 
'Kondo, F.'     2 ? 
'Bekker, G.J.'  3 ? 
'Liao, Z.'      4 ? 
'Yamashita, M.' 5 ? 
'Iida, A.'      6 ? 
'Ito, N.'       7 ? 
'Kamiya, N.'    8 ? 
'Oda, M.'       9 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            281 
_citation.language                  ? 
_citation.page_first                136597 
_citation.page_last                 136597 
_citation.title                     
'Structural dynamics of the Ca 2+ -regulated cutinase towards structure-based improvement of PET degradation activity.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2024.136597 
_citation.pdbx_database_id_PubMed   39419144 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Numoto, N.'    1 ? 
primary 'Kondo, F.'     2 ? 
primary 'Bekker, G.J.'  3 ? 
primary 'Liao, Z.'      4 ? 
primary 'Yamashita, M.' 5 ? 
primary 'Iida, A.'      6 ? 
primary 'Ito, N.'       7 ? 
primary 'Kamiya, N.'    8 ? 
primary 'Oda, M.'       9 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Alpha/beta hydrolase family protein'                              28889.537 2   3.1.1.74 
Q123H/Q138A/S176A/N202H/S226P/R228S/D250C/E296C ? ? 
2 non-polymer syn 'AMMONIUM ION'                                                     18.038    1   ?        ? ? ? 
3 non-polymer syn '2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL' 209.240   1   ?        ? ? ? 
4 non-polymer syn '4-(2-hydroxyethyloxycarbonyl)benzoic acid'                        210.183   2   ?        ? ? ? 
5 non-polymer syn GLYCEROL                                                           92.094    1   ?        ? ? ? 
6 water       nat water                                                              18.015    258 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        Cutinase 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPNPYERGPDPTEDSIEAIRGPFSVATERVSSFASGFGGGTIYYPRETDEGTFGAVAVAPGFTASQGSMSWYGERVASHG
FIVFTIDTNTRLDAPGQRGRQLLAALDYLVERSDRKVRERLDPNRLAVMGHAMGGGGSLEATVMRPSLKASIPLTPWHLD
KTWGQVQVPTFIIGAELDTIAPVSTHAKPFYESLPSSLPKAYMELCGATHFAPNIPNTTIAKYVISWLKRFVDEDTRYSQ
FLCPNPTDRAICEYRSTCPYKLN
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPNPYERGPDPTEDSIEAIRGPFSVATERVSSFASGFGGGTIYYPRETDEGTFGAVAVAPGFTASQGSMSWYGERVASHG
FIVFTIDTNTRLDAPGQRGRQLLAALDYLVERSDRKVRERLDPNRLAVMGHAMGGGGSLEATVMRPSLKASIPLTPWHLD
KTWGQVQVPTFIIGAELDTIAPVSTHAKPFYESLPSSLPKAYMELCGATHFAPNIPNTTIAKYVISWLKRFVDEDTRYSQ
FLCPNPTDRAICEYRSTCPYKLN
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'AMMONIUM ION'                                                     NH4 
3 '2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL' BTB 
4 '4-(2-hydroxyethyloxycarbonyl)benzoic acid'                        C9C 
5 GLYCEROL                                                           GOL 
6 water                                                              HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   ASN n 
1 4   PRO n 
1 5   TYR n 
1 6   GLU n 
1 7   ARG n 
1 8   GLY n 
1 9   PRO n 
1 10  ASP n 
1 11  PRO n 
1 12  THR n 
1 13  GLU n 
1 14  ASP n 
1 15  SER n 
1 16  ILE n 
1 17  GLU n 
1 18  ALA n 
1 19  ILE n 
1 20  ARG n 
1 21  GLY n 
1 22  PRO n 
1 23  PHE n 
1 24  SER n 
1 25  VAL n 
1 26  ALA n 
1 27  THR n 
1 28  GLU n 
1 29  ARG n 
1 30  VAL n 
1 31  SER n 
1 32  SER n 
1 33  PHE n 
1 34  ALA n 
1 35  SER n 
1 36  GLY n 
1 37  PHE n 
1 38  GLY n 
1 39  GLY n 
1 40  GLY n 
1 41  THR n 
1 42  ILE n 
1 43  TYR n 
1 44  TYR n 
1 45  PRO n 
1 46  ARG n 
1 47  GLU n 
1 48  THR n 
1 49  ASP n 
1 50  GLU n 
1 51  GLY n 
1 52  THR n 
1 53  PHE n 
1 54  GLY n 
1 55  ALA n 
1 56  VAL n 
1 57  ALA n 
1 58  VAL n 
1 59  ALA n 
1 60  PRO n 
1 61  GLY n 
1 62  PHE n 
1 63  THR n 
1 64  ALA n 
1 65  SER n 
1 66  GLN n 
1 67  GLY n 
1 68  SER n 
1 69  MET n 
1 70  SER n 
1 71  TRP n 
1 72  TYR n 
1 73  GLY n 
1 74  GLU n 
1 75  ARG n 
1 76  VAL n 
1 77  ALA n 
1 78  SER n 
1 79  HIS n 
1 80  GLY n 
1 81  PHE n 
1 82  ILE n 
1 83  VAL n 
1 84  PHE n 
1 85  THR n 
1 86  ILE n 
1 87  ASP n 
1 88  THR n 
1 89  ASN n 
1 90  THR n 
1 91  ARG n 
1 92  LEU n 
1 93  ASP n 
1 94  ALA n 
1 95  PRO n 
1 96  GLY n 
1 97  GLN n 
1 98  ARG n 
1 99  GLY n 
1 100 ARG n 
1 101 GLN n 
1 102 LEU n 
1 103 LEU n 
1 104 ALA n 
1 105 ALA n 
1 106 LEU n 
1 107 ASP n 
1 108 TYR n 
1 109 LEU n 
1 110 VAL n 
1 111 GLU n 
1 112 ARG n 
1 113 SER n 
1 114 ASP n 
1 115 ARG n 
1 116 LYS n 
1 117 VAL n 
1 118 ARG n 
1 119 GLU n 
1 120 ARG n 
1 121 LEU n 
1 122 ASP n 
1 123 PRO n 
1 124 ASN n 
1 125 ARG n 
1 126 LEU n 
1 127 ALA n 
1 128 VAL n 
1 129 MET n 
1 130 GLY n 
1 131 HIS n 
1 132 ALA n 
1 133 MET n 
1 134 GLY n 
1 135 GLY n 
1 136 GLY n 
1 137 GLY n 
1 138 SER n 
1 139 LEU n 
1 140 GLU n 
1 141 ALA n 
1 142 THR n 
1 143 VAL n 
1 144 MET n 
1 145 ARG n 
1 146 PRO n 
1 147 SER n 
1 148 LEU n 
1 149 LYS n 
1 150 ALA n 
1 151 SER n 
1 152 ILE n 
1 153 PRO n 
1 154 LEU n 
1 155 THR n 
1 156 PRO n 
1 157 TRP n 
1 158 HIS n 
1 159 LEU n 
1 160 ASP n 
1 161 LYS n 
1 162 THR n 
1 163 TRP n 
1 164 GLY n 
1 165 GLN n 
1 166 VAL n 
1 167 GLN n 
1 168 VAL n 
1 169 PRO n 
1 170 THR n 
1 171 PHE n 
1 172 ILE n 
1 173 ILE n 
1 174 GLY n 
1 175 ALA n 
1 176 GLU n 
1 177 LEU n 
1 178 ASP n 
1 179 THR n 
1 180 ILE n 
1 181 ALA n 
1 182 PRO n 
1 183 VAL n 
1 184 SER n 
1 185 THR n 
1 186 HIS n 
1 187 ALA n 
1 188 LYS n 
1 189 PRO n 
1 190 PHE n 
1 191 TYR n 
1 192 GLU n 
1 193 SER n 
1 194 LEU n 
1 195 PRO n 
1 196 SER n 
1 197 SER n 
1 198 LEU n 
1 199 PRO n 
1 200 LYS n 
1 201 ALA n 
1 202 TYR n 
1 203 MET n 
1 204 GLU n 
1 205 LEU n 
1 206 CYS n 
1 207 GLY n 
1 208 ALA n 
1 209 THR n 
1 210 HIS n 
1 211 PHE n 
1 212 ALA n 
1 213 PRO n 
1 214 ASN n 
1 215 ILE n 
1 216 PRO n 
1 217 ASN n 
1 218 THR n 
1 219 THR n 
1 220 ILE n 
1 221 ALA n 
1 222 LYS n 
1 223 TYR n 
1 224 VAL n 
1 225 ILE n 
1 226 SER n 
1 227 TRP n 
1 228 LEU n 
1 229 LYS n 
1 230 ARG n 
1 231 PHE n 
1 232 VAL n 
1 233 ASP n 
1 234 GLU n 
1 235 ASP n 
1 236 THR n 
1 237 ARG n 
1 238 TYR n 
1 239 SER n 
1 240 GLN n 
1 241 PHE n 
1 242 LEU n 
1 243 CYS n 
1 244 PRO n 
1 245 ASN n 
1 246 PRO n 
1 247 THR n 
1 248 ASP n 
1 249 ARG n 
1 250 ALA n 
1 251 ILE n 
1 252 CYS n 
1 253 GLU n 
1 254 TYR n 
1 255 ARG n 
1 256 SER n 
1 257 THR n 
1 258 CYS n 
1 259 PRO n 
1 260 TYR n 
1 261 LYS n 
1 262 LEU n 
1 263 ASN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   263 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'Cut190, SAMN02982918_2340' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Saccharomonospora viridis' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1852 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'Rosetta-gami B(DE3)' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pQE80L 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                            ?                                
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                           ?                                
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                         ?                                
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                    ?                                
'C4 H7 N O4'     133.103 
BTB non-polymer         . '2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL' 'BIS-TRIS BUFFER'                
'C8 H19 N O5'    209.240 
C9C non-polymer         . '4-(2-hydroxyethyloxycarbonyl)benzoic acid'                        'monohydroxyethyl terephthalate' 
'C10 H10 O5'     210.183 
CYS 'L-peptide linking' y CYSTEINE                                                           ?                                
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                          ?                                
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                    ?                                
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                            ?                                
'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL                                                           'GLYCERIN; PROPANE-1,2,3-TRIOL'  
'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE                                                          ?                                
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                              ?                                
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                         ?                                
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                            ?                                
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                             ?                                
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                         ?                                
'C5 H11 N O2 S'  149.211 
NH4 non-polymer         . 'AMMONIUM ION'                                                     ?                                
'H4 N 1'         18.038  
PHE 'L-peptide linking' y PHENYLALANINE                                                      ?                                
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                            ?                                
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                             ?                                
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                          ?                                
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                         ?                                
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                           ?                                
'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                             ?                                
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   45  ?   ?   ?   A . n 
A 1 2   PRO 2   46  46  PRO PRO A . n 
A 1 3   ASN 3   47  47  ASN ASN A . n 
A 1 4   PRO 4   48  48  PRO PRO A . n 
A 1 5   TYR 5   49  49  TYR TYR A . n 
A 1 6   GLU 6   50  50  GLU GLU A . n 
A 1 7   ARG 7   51  51  ARG ARG A . n 
A 1 8   GLY 8   52  52  GLY GLY A . n 
A 1 9   PRO 9   53  53  PRO PRO A . n 
A 1 10  ASP 10  54  54  ASP ASP A . n 
A 1 11  PRO 11  55  55  PRO PRO A . n 
A 1 12  THR 12  56  56  THR THR A . n 
A 1 13  GLU 13  57  57  GLU GLU A . n 
A 1 14  ASP 14  58  58  ASP ASP A . n 
A 1 15  SER 15  59  59  SER SER A . n 
A 1 16  ILE 16  60  60  ILE ILE A . n 
A 1 17  GLU 17  61  61  GLU GLU A . n 
A 1 18  ALA 18  62  62  ALA ALA A . n 
A 1 19  ILE 19  63  63  ILE ILE A . n 
A 1 20  ARG 20  64  64  ARG ARG A . n 
A 1 21  GLY 21  65  65  GLY GLY A . n 
A 1 22  PRO 22  66  66  PRO PRO A . n 
A 1 23  PHE 23  67  67  PHE PHE A . n 
A 1 24  SER 24  68  68  SER SER A . n 
A 1 25  VAL 25  69  69  VAL VAL A . n 
A 1 26  ALA 26  70  70  ALA ALA A . n 
A 1 27  THR 27  71  71  THR THR A . n 
A 1 28  GLU 28  72  72  GLU GLU A . n 
A 1 29  ARG 29  73  73  ARG ARG A . n 
A 1 30  VAL 30  74  74  VAL VAL A . n 
A 1 31  SER 31  75  75  SER SER A . n 
A 1 32  SER 32  76  76  SER SER A . n 
A 1 33  PHE 33  77  77  PHE PHE A . n 
A 1 34  ALA 34  78  78  ALA ALA A . n 
A 1 35  SER 35  79  79  SER SER A . n 
A 1 36  GLY 36  80  80  GLY GLY A . n 
A 1 37  PHE 37  81  81  PHE PHE A . n 
A 1 38  GLY 38  82  82  GLY GLY A . n 
A 1 39  GLY 39  83  83  GLY GLY A . n 
A 1 40  GLY 40  84  84  GLY GLY A . n 
A 1 41  THR 41  85  85  THR THR A . n 
A 1 42  ILE 42  86  86  ILE ILE A . n 
A 1 43  TYR 43  87  87  TYR TYR A . n 
A 1 44  TYR 44  88  88  TYR TYR A . n 
A 1 45  PRO 45  89  89  PRO PRO A . n 
A 1 46  ARG 46  90  90  ARG ARG A . n 
A 1 47  GLU 47  91  91  GLU GLU A . n 
A 1 48  THR 48  92  92  THR THR A . n 
A 1 49  ASP 49  93  93  ASP ASP A . n 
A 1 50  GLU 50  94  94  GLU GLU A . n 
A 1 51  GLY 51  95  95  GLY GLY A . n 
A 1 52  THR 52  96  96  THR THR A . n 
A 1 53  PHE 53  97  97  PHE PHE A . n 
A 1 54  GLY 54  98  98  GLY GLY A . n 
A 1 55  ALA 55  99  99  ALA ALA A . n 
A 1 56  VAL 56  100 100 VAL VAL A . n 
A 1 57  ALA 57  101 101 ALA ALA A . n 
A 1 58  VAL 58  102 102 VAL VAL A . n 
A 1 59  ALA 59  103 103 ALA ALA A . n 
A 1 60  PRO 60  104 104 PRO PRO A . n 
A 1 61  GLY 61  105 105 GLY GLY A . n 
A 1 62  PHE 62  106 106 PHE PHE A . n 
A 1 63  THR 63  107 107 THR THR A . n 
A 1 64  ALA 64  108 108 ALA ALA A . n 
A 1 65  SER 65  109 109 SER SER A . n 
A 1 66  GLN 66  110 110 GLN GLN A . n 
A 1 67  GLY 67  111 111 GLY GLY A . n 
A 1 68  SER 68  112 112 SER SER A . n 
A 1 69  MET 69  113 113 MET MET A . n 
A 1 70  SER 70  114 114 SER SER A . n 
A 1 71  TRP 71  115 115 TRP TRP A . n 
A 1 72  TYR 72  116 116 TYR TYR A . n 
A 1 73  GLY 73  117 117 GLY GLY A . n 
A 1 74  GLU 74  118 118 GLU GLU A . n 
A 1 75  ARG 75  119 119 ARG ARG A . n 
A 1 76  VAL 76  120 120 VAL VAL A . n 
A 1 77  ALA 77  121 121 ALA ALA A . n 
A 1 78  SER 78  122 122 SER SER A . n 
A 1 79  HIS 79  123 123 HIS HIS A . n 
A 1 80  GLY 80  124 124 GLY GLY A . n 
A 1 81  PHE 81  125 125 PHE PHE A . n 
A 1 82  ILE 82  126 126 ILE ILE A . n 
A 1 83  VAL 83  127 127 VAL VAL A . n 
A 1 84  PHE 84  128 128 PHE PHE A . n 
A 1 85  THR 85  129 129 THR THR A . n 
A 1 86  ILE 86  130 130 ILE ILE A . n 
A 1 87  ASP 87  131 131 ASP ASP A . n 
A 1 88  THR 88  132 132 THR THR A . n 
A 1 89  ASN 89  133 133 ASN ASN A . n 
A 1 90  THR 90  134 134 THR THR A . n 
A 1 91  ARG 91  135 135 ARG ARG A . n 
A 1 92  LEU 92  136 136 LEU LEU A . n 
A 1 93  ASP 93  137 137 ASP ASP A . n 
A 1 94  ALA 94  138 138 ALA ALA A . n 
A 1 95  PRO 95  139 139 PRO PRO A . n 
A 1 96  GLY 96  140 140 GLY GLY A . n 
A 1 97  GLN 97  141 141 GLN GLN A . n 
A 1 98  ARG 98  142 142 ARG ARG A . n 
A 1 99  GLY 99  143 143 GLY GLY A . n 
A 1 100 ARG 100 144 144 ARG ARG A . n 
A 1 101 GLN 101 145 145 GLN GLN A . n 
A 1 102 LEU 102 146 146 LEU LEU A . n 
A 1 103 LEU 103 147 147 LEU LEU A . n 
A 1 104 ALA 104 148 148 ALA ALA A . n 
A 1 105 ALA 105 149 149 ALA ALA A . n 
A 1 106 LEU 106 150 150 LEU LEU A . n 
A 1 107 ASP 107 151 151 ASP ASP A . n 
A 1 108 TYR 108 152 152 TYR TYR A . n 
A 1 109 LEU 109 153 153 LEU LEU A . n 
A 1 110 VAL 110 154 154 VAL VAL A . n 
A 1 111 GLU 111 155 155 GLU GLU A . n 
A 1 112 ARG 112 156 156 ARG ARG A . n 
A 1 113 SER 113 157 157 SER SER A . n 
A 1 114 ASP 114 158 158 ASP ASP A . n 
A 1 115 ARG 115 159 159 ARG ARG A . n 
A 1 116 LYS 116 160 160 LYS LYS A . n 
A 1 117 VAL 117 161 161 VAL VAL A . n 
A 1 118 ARG 118 162 162 ARG ARG A . n 
A 1 119 GLU 119 163 163 GLU GLU A . n 
A 1 120 ARG 120 164 164 ARG ARG A . n 
A 1 121 LEU 121 165 165 LEU LEU A . n 
A 1 122 ASP 122 166 166 ASP ASP A . n 
A 1 123 PRO 123 167 167 PRO PRO A . n 
A 1 124 ASN 124 168 168 ASN ASN A . n 
A 1 125 ARG 125 169 169 ARG ARG A . n 
A 1 126 LEU 126 170 170 LEU LEU A . n 
A 1 127 ALA 127 171 171 ALA ALA A . n 
A 1 128 VAL 128 172 172 VAL VAL A . n 
A 1 129 MET 129 173 173 MET MET A . n 
A 1 130 GLY 130 174 174 GLY GLY A . n 
A 1 131 HIS 131 175 175 HIS HIS A . n 
A 1 132 ALA 132 176 176 ALA ALA A . n 
A 1 133 MET 133 177 177 MET MET A . n 
A 1 134 GLY 134 178 178 GLY GLY A . n 
A 1 135 GLY 135 179 179 GLY GLY A . n 
A 1 136 GLY 136 180 180 GLY GLY A . n 
A 1 137 GLY 137 181 181 GLY GLY A . n 
A 1 138 SER 138 182 182 SER SER A . n 
A 1 139 LEU 139 183 183 LEU LEU A . n 
A 1 140 GLU 140 184 184 GLU GLU A . n 
A 1 141 ALA 141 185 185 ALA ALA A . n 
A 1 142 THR 142 186 186 THR THR A . n 
A 1 143 VAL 143 187 187 VAL VAL A . n 
A 1 144 MET 144 188 188 MET MET A . n 
A 1 145 ARG 145 189 189 ARG ARG A . n 
A 1 146 PRO 146 190 190 PRO PRO A . n 
A 1 147 SER 147 191 191 SER SER A . n 
A 1 148 LEU 148 192 192 LEU LEU A . n 
A 1 149 LYS 149 193 193 LYS LYS A . n 
A 1 150 ALA 150 194 194 ALA ALA A . n 
A 1 151 SER 151 195 195 SER SER A . n 
A 1 152 ILE 152 196 196 ILE ILE A . n 
A 1 153 PRO 153 197 197 PRO PRO A . n 
A 1 154 LEU 154 198 198 LEU LEU A . n 
A 1 155 THR 155 199 199 THR THR A . n 
A 1 156 PRO 156 200 200 PRO PRO A . n 
A 1 157 TRP 157 201 201 TRP TRP A . n 
A 1 158 HIS 158 202 202 HIS HIS A . n 
A 1 159 LEU 159 203 203 LEU LEU A . n 
A 1 160 ASP 160 204 204 ASP ASP A . n 
A 1 161 LYS 161 205 205 LYS LYS A . n 
A 1 162 THR 162 206 206 THR THR A . n 
A 1 163 TRP 163 207 207 TRP TRP A . n 
A 1 164 GLY 164 208 208 GLY GLY A . n 
A 1 165 GLN 165 209 209 GLN GLN A . n 
A 1 166 VAL 166 210 210 VAL VAL A . n 
A 1 167 GLN 167 211 211 GLN GLN A . n 
A 1 168 VAL 168 212 212 VAL VAL A . n 
A 1 169 PRO 169 213 213 PRO PRO A . n 
A 1 170 THR 170 214 214 THR THR A . n 
A 1 171 PHE 171 215 215 PHE PHE A . n 
A 1 172 ILE 172 216 216 ILE ILE A . n 
A 1 173 ILE 173 217 217 ILE ILE A . n 
A 1 174 GLY 174 218 218 GLY GLY A . n 
A 1 175 ALA 175 219 219 ALA ALA A . n 
A 1 176 GLU 176 220 220 GLU GLU A . n 
A 1 177 LEU 177 221 221 LEU LEU A . n 
A 1 178 ASP 178 222 222 ASP ASP A . n 
A 1 179 THR 179 223 223 THR THR A . n 
A 1 180 ILE 180 224 224 ILE ILE A . n 
A 1 181 ALA 181 225 225 ALA ALA A . n 
A 1 182 PRO 182 226 226 PRO PRO A . n 
A 1 183 VAL 183 227 227 VAL VAL A . n 
A 1 184 SER 184 228 228 SER SER A . n 
A 1 185 THR 185 229 229 THR THR A . n 
A 1 186 HIS 186 230 230 HIS HIS A . n 
A 1 187 ALA 187 231 231 ALA ALA A . n 
A 1 188 LYS 188 232 232 LYS LYS A . n 
A 1 189 PRO 189 233 233 PRO PRO A . n 
A 1 190 PHE 190 234 234 PHE PHE A . n 
A 1 191 TYR 191 235 235 TYR TYR A . n 
A 1 192 GLU 192 236 236 GLU GLU A . n 
A 1 193 SER 193 237 237 SER SER A . n 
A 1 194 LEU 194 238 238 LEU LEU A . n 
A 1 195 PRO 195 239 239 PRO PRO A . n 
A 1 196 SER 196 240 240 SER SER A . n 
A 1 197 SER 197 241 241 SER SER A . n 
A 1 198 LEU 198 242 242 LEU LEU A . n 
A 1 199 PRO 199 243 243 PRO PRO A . n 
A 1 200 LYS 200 244 244 LYS LYS A . n 
A 1 201 ALA 201 245 245 ALA ALA A . n 
A 1 202 TYR 202 246 246 TYR TYR A . n 
A 1 203 MET 203 247 247 MET MET A . n 
A 1 204 GLU 204 248 248 GLU GLU A . n 
A 1 205 LEU 205 249 249 LEU LEU A . n 
A 1 206 CYS 206 250 250 CYS CYS A . n 
A 1 207 GLY 207 251 251 GLY GLY A . n 
A 1 208 ALA 208 252 252 ALA ALA A . n 
A 1 209 THR 209 253 253 THR THR A . n 
A 1 210 HIS 210 254 254 HIS HIS A . n 
A 1 211 PHE 211 255 255 PHE PHE A . n 
A 1 212 ALA 212 256 256 ALA ALA A . n 
A 1 213 PRO 213 257 257 PRO PRO A . n 
A 1 214 ASN 214 258 258 ASN ASN A . n 
A 1 215 ILE 215 259 259 ILE ILE A . n 
A 1 216 PRO 216 260 260 PRO PRO A . n 
A 1 217 ASN 217 261 261 ASN ASN A . n 
A 1 218 THR 218 262 262 THR THR A . n 
A 1 219 THR 219 263 263 THR THR A . n 
A 1 220 ILE 220 264 264 ILE ILE A . n 
A 1 221 ALA 221 265 265 ALA ALA A . n 
A 1 222 LYS 222 266 266 LYS LYS A . n 
A 1 223 TYR 223 267 267 TYR TYR A . n 
A 1 224 VAL 224 268 268 VAL VAL A . n 
A 1 225 ILE 225 269 269 ILE ILE A . n 
A 1 226 SER 226 270 270 SER SER A . n 
A 1 227 TRP 227 271 271 TRP TRP A . n 
A 1 228 LEU 228 272 272 LEU LEU A . n 
A 1 229 LYS 229 273 273 LYS LYS A . n 
A 1 230 ARG 230 274 274 ARG ARG A . n 
A 1 231 PHE 231 275 275 PHE PHE A . n 
A 1 232 VAL 232 276 276 VAL VAL A . n 
A 1 233 ASP 233 277 277 ASP ASP A . n 
A 1 234 GLU 234 278 278 GLU GLU A . n 
A 1 235 ASP 235 279 279 ASP ASP A . n 
A 1 236 THR 236 280 280 THR THR A . n 
A 1 237 ARG 237 281 281 ARG ARG A . n 
A 1 238 TYR 238 282 282 TYR TYR A . n 
A 1 239 SER 239 283 283 SER SER A . n 
A 1 240 GLN 240 284 284 GLN GLN A . n 
A 1 241 PHE 241 285 285 PHE PHE A . n 
A 1 242 LEU 242 286 286 LEU LEU A . n 
A 1 243 CYS 243 287 287 CYS CYS A . n 
A 1 244 PRO 244 288 288 PRO PRO A . n 
A 1 245 ASN 245 289 289 ASN ASN A . n 
A 1 246 PRO 246 290 290 PRO PRO A . n 
A 1 247 THR 247 291 291 THR THR A . n 
A 1 248 ASP 248 292 292 ASP ASP A . n 
A 1 249 ARG 249 293 293 ARG ARG A . n 
A 1 250 ALA 250 294 294 ALA ALA A . n 
A 1 251 ILE 251 295 295 ILE ILE A . n 
A 1 252 CYS 252 296 296 CYS CYS A . n 
A 1 253 GLU 253 297 297 GLU GLU A . n 
A 1 254 TYR 254 298 298 TYR TYR A . n 
A 1 255 ARG 255 299 299 ARG ARG A . n 
A 1 256 SER 256 300 300 SER SER A . n 
A 1 257 THR 257 301 301 THR THR A . n 
A 1 258 CYS 258 302 302 CYS CYS A . n 
A 1 259 PRO 259 303 303 PRO PRO A . n 
A 1 260 TYR 260 304 304 TYR TYR A . n 
A 1 261 LYS 261 305 ?   ?   ?   A . n 
A 1 262 LEU 262 306 ?   ?   ?   A . n 
A 1 263 ASN 263 307 ?   ?   ?   A . n 
B 1 1   GLY 1   45  ?   ?   ?   B . n 
B 1 2   PRO 2   46  46  PRO PRO B . n 
B 1 3   ASN 3   47  47  ASN ASN B . n 
B 1 4   PRO 4   48  48  PRO PRO B . n 
B 1 5   TYR 5   49  49  TYR TYR B . n 
B 1 6   GLU 6   50  50  GLU GLU B . n 
B 1 7   ARG 7   51  51  ARG ARG B . n 
B 1 8   GLY 8   52  52  GLY GLY B . n 
B 1 9   PRO 9   53  53  PRO PRO B . n 
B 1 10  ASP 10  54  54  ASP ASP B . n 
B 1 11  PRO 11  55  55  PRO PRO B . n 
B 1 12  THR 12  56  56  THR THR B . n 
B 1 13  GLU 13  57  57  GLU GLU B . n 
B 1 14  ASP 14  58  58  ASP ASP B . n 
B 1 15  SER 15  59  59  SER SER B . n 
B 1 16  ILE 16  60  60  ILE ILE B . n 
B 1 17  GLU 17  61  61  GLU GLU B . n 
B 1 18  ALA 18  62  62  ALA ALA B . n 
B 1 19  ILE 19  63  63  ILE ILE B . n 
B 1 20  ARG 20  64  64  ARG ARG B . n 
B 1 21  GLY 21  65  65  GLY GLY B . n 
B 1 22  PRO 22  66  66  PRO PRO B . n 
B 1 23  PHE 23  67  67  PHE PHE B . n 
B 1 24  SER 24  68  68  SER SER B . n 
B 1 25  VAL 25  69  69  VAL VAL B . n 
B 1 26  ALA 26  70  70  ALA ALA B . n 
B 1 27  THR 27  71  71  THR THR B . n 
B 1 28  GLU 28  72  72  GLU GLU B . n 
B 1 29  ARG 29  73  73  ARG ARG B . n 
B 1 30  VAL 30  74  74  VAL VAL B . n 
B 1 31  SER 31  75  75  SER SER B . n 
B 1 32  SER 32  76  76  SER SER B . n 
B 1 33  PHE 33  77  77  PHE PHE B . n 
B 1 34  ALA 34  78  78  ALA ALA B . n 
B 1 35  SER 35  79  79  SER SER B . n 
B 1 36  GLY 36  80  80  GLY GLY B . n 
B 1 37  PHE 37  81  81  PHE PHE B . n 
B 1 38  GLY 38  82  82  GLY GLY B . n 
B 1 39  GLY 39  83  83  GLY GLY B . n 
B 1 40  GLY 40  84  84  GLY GLY B . n 
B 1 41  THR 41  85  85  THR THR B . n 
B 1 42  ILE 42  86  86  ILE ILE B . n 
B 1 43  TYR 43  87  87  TYR TYR B . n 
B 1 44  TYR 44  88  88  TYR TYR B . n 
B 1 45  PRO 45  89  89  PRO PRO B . n 
B 1 46  ARG 46  90  90  ARG ARG B . n 
B 1 47  GLU 47  91  91  GLU GLU B . n 
B 1 48  THR 48  92  92  THR THR B . n 
B 1 49  ASP 49  93  93  ASP ASP B . n 
B 1 50  GLU 50  94  94  GLU GLU B . n 
B 1 51  GLY 51  95  95  GLY GLY B . n 
B 1 52  THR 52  96  96  THR THR B . n 
B 1 53  PHE 53  97  97  PHE PHE B . n 
B 1 54  GLY 54  98  98  GLY GLY B . n 
B 1 55  ALA 55  99  99  ALA ALA B . n 
B 1 56  VAL 56  100 100 VAL VAL B . n 
B 1 57  ALA 57  101 101 ALA ALA B . n 
B 1 58  VAL 58  102 102 VAL VAL B . n 
B 1 59  ALA 59  103 103 ALA ALA B . n 
B 1 60  PRO 60  104 104 PRO PRO B . n 
B 1 61  GLY 61  105 105 GLY GLY B . n 
B 1 62  PHE 62  106 106 PHE PHE B . n 
B 1 63  THR 63  107 107 THR THR B . n 
B 1 64  ALA 64  108 108 ALA ALA B . n 
B 1 65  SER 65  109 109 SER SER B . n 
B 1 66  GLN 66  110 110 GLN GLN B . n 
B 1 67  GLY 67  111 111 GLY GLY B . n 
B 1 68  SER 68  112 112 SER SER B . n 
B 1 69  MET 69  113 113 MET MET B . n 
B 1 70  SER 70  114 114 SER SER B . n 
B 1 71  TRP 71  115 115 TRP TRP B . n 
B 1 72  TYR 72  116 116 TYR TYR B . n 
B 1 73  GLY 73  117 117 GLY GLY B . n 
B 1 74  GLU 74  118 118 GLU GLU B . n 
B 1 75  ARG 75  119 119 ARG ARG B . n 
B 1 76  VAL 76  120 120 VAL VAL B . n 
B 1 77  ALA 77  121 121 ALA ALA B . n 
B 1 78  SER 78  122 122 SER SER B . n 
B 1 79  HIS 79  123 123 HIS HIS B . n 
B 1 80  GLY 80  124 124 GLY GLY B . n 
B 1 81  PHE 81  125 125 PHE PHE B . n 
B 1 82  ILE 82  126 126 ILE ILE B . n 
B 1 83  VAL 83  127 127 VAL VAL B . n 
B 1 84  PHE 84  128 128 PHE PHE B . n 
B 1 85  THR 85  129 129 THR THR B . n 
B 1 86  ILE 86  130 130 ILE ILE B . n 
B 1 87  ASP 87  131 131 ASP ASP B . n 
B 1 88  THR 88  132 132 THR THR B . n 
B 1 89  ASN 89  133 133 ASN ASN B . n 
B 1 90  THR 90  134 134 THR THR B . n 
B 1 91  ARG 91  135 135 ARG ARG B . n 
B 1 92  LEU 92  136 136 LEU LEU B . n 
B 1 93  ASP 93  137 137 ASP ASP B . n 
B 1 94  ALA 94  138 138 ALA ALA B . n 
B 1 95  PRO 95  139 139 PRO PRO B . n 
B 1 96  GLY 96  140 140 GLY GLY B . n 
B 1 97  GLN 97  141 141 GLN GLN B . n 
B 1 98  ARG 98  142 142 ARG ARG B . n 
B 1 99  GLY 99  143 143 GLY GLY B . n 
B 1 100 ARG 100 144 144 ARG ARG B . n 
B 1 101 GLN 101 145 145 GLN GLN B . n 
B 1 102 LEU 102 146 146 LEU LEU B . n 
B 1 103 LEU 103 147 147 LEU LEU B . n 
B 1 104 ALA 104 148 148 ALA ALA B . n 
B 1 105 ALA 105 149 149 ALA ALA B . n 
B 1 106 LEU 106 150 150 LEU LEU B . n 
B 1 107 ASP 107 151 151 ASP ASP B . n 
B 1 108 TYR 108 152 152 TYR TYR B . n 
B 1 109 LEU 109 153 153 LEU LEU B . n 
B 1 110 VAL 110 154 154 VAL VAL B . n 
B 1 111 GLU 111 155 155 GLU GLU B . n 
B 1 112 ARG 112 156 156 ARG ARG B . n 
B 1 113 SER 113 157 157 SER SER B . n 
B 1 114 ASP 114 158 158 ASP ASP B . n 
B 1 115 ARG 115 159 159 ARG ARG B . n 
B 1 116 LYS 116 160 160 LYS LYS B . n 
B 1 117 VAL 117 161 161 VAL VAL B . n 
B 1 118 ARG 118 162 162 ARG ARG B . n 
B 1 119 GLU 119 163 163 GLU GLU B . n 
B 1 120 ARG 120 164 164 ARG ARG B . n 
B 1 121 LEU 121 165 165 LEU LEU B . n 
B 1 122 ASP 122 166 166 ASP ASP B . n 
B 1 123 PRO 123 167 167 PRO PRO B . n 
B 1 124 ASN 124 168 168 ASN ASN B . n 
B 1 125 ARG 125 169 169 ARG ARG B . n 
B 1 126 LEU 126 170 170 LEU LEU B . n 
B 1 127 ALA 127 171 171 ALA ALA B . n 
B 1 128 VAL 128 172 172 VAL VAL B . n 
B 1 129 MET 129 173 173 MET MET B . n 
B 1 130 GLY 130 174 174 GLY GLY B . n 
B 1 131 HIS 131 175 175 HIS HIS B . n 
B 1 132 ALA 132 176 176 ALA ALA B . n 
B 1 133 MET 133 177 177 MET MET B . n 
B 1 134 GLY 134 178 178 GLY GLY B . n 
B 1 135 GLY 135 179 179 GLY GLY B . n 
B 1 136 GLY 136 180 180 GLY GLY B . n 
B 1 137 GLY 137 181 181 GLY GLY B . n 
B 1 138 SER 138 182 182 SER SER B . n 
B 1 139 LEU 139 183 183 LEU LEU B . n 
B 1 140 GLU 140 184 184 GLU GLU B . n 
B 1 141 ALA 141 185 185 ALA ALA B . n 
B 1 142 THR 142 186 186 THR THR B . n 
B 1 143 VAL 143 187 187 VAL VAL B . n 
B 1 144 MET 144 188 188 MET MET B . n 
B 1 145 ARG 145 189 189 ARG ARG B . n 
B 1 146 PRO 146 190 190 PRO PRO B . n 
B 1 147 SER 147 191 191 SER SER B . n 
B 1 148 LEU 148 192 192 LEU LEU B . n 
B 1 149 LYS 149 193 193 LYS LYS B . n 
B 1 150 ALA 150 194 194 ALA ALA B . n 
B 1 151 SER 151 195 195 SER SER B . n 
B 1 152 ILE 152 196 196 ILE ILE B . n 
B 1 153 PRO 153 197 197 PRO PRO B . n 
B 1 154 LEU 154 198 198 LEU LEU B . n 
B 1 155 THR 155 199 199 THR THR B . n 
B 1 156 PRO 156 200 200 PRO PRO B . n 
B 1 157 TRP 157 201 201 TRP TRP B . n 
B 1 158 HIS 158 202 202 HIS HIS B . n 
B 1 159 LEU 159 203 203 LEU LEU B . n 
B 1 160 ASP 160 204 204 ASP ASP B . n 
B 1 161 LYS 161 205 205 LYS LYS B . n 
B 1 162 THR 162 206 206 THR THR B . n 
B 1 163 TRP 163 207 207 TRP TRP B . n 
B 1 164 GLY 164 208 208 GLY GLY B . n 
B 1 165 GLN 165 209 209 GLN GLN B . n 
B 1 166 VAL 166 210 210 VAL VAL B . n 
B 1 167 GLN 167 211 211 GLN GLN B . n 
B 1 168 VAL 168 212 212 VAL VAL B . n 
B 1 169 PRO 169 213 213 PRO PRO B . n 
B 1 170 THR 170 214 214 THR THR B . n 
B 1 171 PHE 171 215 215 PHE PHE B . n 
B 1 172 ILE 172 216 216 ILE ILE B . n 
B 1 173 ILE 173 217 217 ILE ILE B . n 
B 1 174 GLY 174 218 218 GLY GLY B . n 
B 1 175 ALA 175 219 219 ALA ALA B . n 
B 1 176 GLU 176 220 220 GLU GLU B . n 
B 1 177 LEU 177 221 221 LEU LEU B . n 
B 1 178 ASP 178 222 222 ASP ASP B . n 
B 1 179 THR 179 223 223 THR THR B . n 
B 1 180 ILE 180 224 224 ILE ILE B . n 
B 1 181 ALA 181 225 225 ALA ALA B . n 
B 1 182 PRO 182 226 226 PRO PRO B . n 
B 1 183 VAL 183 227 227 VAL VAL B . n 
B 1 184 SER 184 228 228 SER SER B . n 
B 1 185 THR 185 229 229 THR THR B . n 
B 1 186 HIS 186 230 230 HIS HIS B . n 
B 1 187 ALA 187 231 231 ALA ALA B . n 
B 1 188 LYS 188 232 232 LYS LYS B . n 
B 1 189 PRO 189 233 233 PRO PRO B . n 
B 1 190 PHE 190 234 234 PHE PHE B . n 
B 1 191 TYR 191 235 235 TYR TYR B . n 
B 1 192 GLU 192 236 236 GLU GLU B . n 
B 1 193 SER 193 237 237 SER SER B . n 
B 1 194 LEU 194 238 238 LEU LEU B . n 
B 1 195 PRO 195 239 239 PRO PRO B . n 
B 1 196 SER 196 240 240 SER SER B . n 
B 1 197 SER 197 241 241 SER SER B . n 
B 1 198 LEU 198 242 242 LEU LEU B . n 
B 1 199 PRO 199 243 243 PRO PRO B . n 
B 1 200 LYS 200 244 244 LYS LYS B . n 
B 1 201 ALA 201 245 245 ALA ALA B . n 
B 1 202 TYR 202 246 246 TYR TYR B . n 
B 1 203 MET 203 247 247 MET MET B . n 
B 1 204 GLU 204 248 248 GLU GLU B . n 
B 1 205 LEU 205 249 249 LEU LEU B . n 
B 1 206 CYS 206 250 250 CYS CYS B . n 
B 1 207 GLY 207 251 251 GLY GLY B . n 
B 1 208 ALA 208 252 252 ALA ALA B . n 
B 1 209 THR 209 253 253 THR THR B . n 
B 1 210 HIS 210 254 254 HIS HIS B . n 
B 1 211 PHE 211 255 255 PHE PHE B . n 
B 1 212 ALA 212 256 256 ALA ALA B . n 
B 1 213 PRO 213 257 257 PRO PRO B . n 
B 1 214 ASN 214 258 258 ASN ASN B . n 
B 1 215 ILE 215 259 259 ILE ILE B . n 
B 1 216 PRO 216 260 260 PRO PRO B . n 
B 1 217 ASN 217 261 261 ASN ASN B . n 
B 1 218 THR 218 262 262 THR THR B . n 
B 1 219 THR 219 263 263 THR THR B . n 
B 1 220 ILE 220 264 264 ILE ILE B . n 
B 1 221 ALA 221 265 265 ALA ALA B . n 
B 1 222 LYS 222 266 266 LYS LYS B . n 
B 1 223 TYR 223 267 267 TYR TYR B . n 
B 1 224 VAL 224 268 268 VAL VAL B . n 
B 1 225 ILE 225 269 269 ILE ILE B . n 
B 1 226 SER 226 270 270 SER SER B . n 
B 1 227 TRP 227 271 271 TRP TRP B . n 
B 1 228 LEU 228 272 272 LEU LEU B . n 
B 1 229 LYS 229 273 273 LYS LYS B . n 
B 1 230 ARG 230 274 274 ARG ARG B . n 
B 1 231 PHE 231 275 275 PHE PHE B . n 
B 1 232 VAL 232 276 276 VAL VAL B . n 
B 1 233 ASP 233 277 277 ASP ASP B . n 
B 1 234 GLU 234 278 278 GLU GLU B . n 
B 1 235 ASP 235 279 279 ASP ASP B . n 
B 1 236 THR 236 280 280 THR THR B . n 
B 1 237 ARG 237 281 281 ARG ARG B . n 
B 1 238 TYR 238 282 282 TYR TYR B . n 
B 1 239 SER 239 283 283 SER SER B . n 
B 1 240 GLN 240 284 284 GLN GLN B . n 
B 1 241 PHE 241 285 285 PHE PHE B . n 
B 1 242 LEU 242 286 286 LEU LEU B . n 
B 1 243 CYS 243 287 287 CYS CYS B . n 
B 1 244 PRO 244 288 288 PRO PRO B . n 
B 1 245 ASN 245 289 289 ASN ASN B . n 
B 1 246 PRO 246 290 290 PRO PRO B . n 
B 1 247 THR 247 291 291 THR THR B . n 
B 1 248 ASP 248 292 292 ASP ASP B . n 
B 1 249 ARG 249 293 293 ARG ARG B . n 
B 1 250 ALA 250 294 294 ALA ALA B . n 
B 1 251 ILE 251 295 295 ILE ILE B . n 
B 1 252 CYS 252 296 296 CYS CYS B . n 
B 1 253 GLU 253 297 297 GLU GLU B . n 
B 1 254 TYR 254 298 298 TYR TYR B . n 
B 1 255 ARG 255 299 299 ARG ARG B . n 
B 1 256 SER 256 300 300 SER SER B . n 
B 1 257 THR 257 301 301 THR THR B . n 
B 1 258 CYS 258 302 302 CYS CYS B . n 
B 1 259 PRO 259 303 303 PRO PRO B . n 
B 1 260 TYR 260 304 304 TYR TYR B . n 
B 1 261 LYS 261 305 ?   ?   ?   B . n 
B 1 262 LEU 262 306 ?   ?   ?   B . n 
B 1 263 ASN 263 307 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        C9C 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   C9C 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 NH4 1   401 402 NH4 NH4 A . 
D 3 BTB 1   402 403 BTB BTB A . 
E 4 C9C 1   403 1   C9C J1K A . 
F 5 GOL 1   401 401 GOL GOL B . 
G 4 C9C 1   402 2   C9C J1K B . 
H 6 HOH 1   501 207 HOH HOH A . 
H 6 HOH 2   502 45  HOH HOH A . 
H 6 HOH 3   503 5   HOH HOH A . 
H 6 HOH 4   504 77  HOH HOH A . 
H 6 HOH 5   505 3   HOH HOH A . 
H 6 HOH 6   506 40  HOH HOH A . 
H 6 HOH 7   507 69  HOH HOH A . 
H 6 HOH 8   508 185 HOH HOH A . 
H 6 HOH 9   509 302 HOH HOH A . 
H 6 HOH 10  510 97  HOH HOH A . 
H 6 HOH 11  511 173 HOH HOH A . 
H 6 HOH 12  512 262 HOH HOH A . 
H 6 HOH 13  513 273 HOH HOH A . 
H 6 HOH 14  514 7   HOH HOH A . 
H 6 HOH 15  515 178 HOH HOH A . 
H 6 HOH 16  516 325 HOH HOH A . 
H 6 HOH 17  517 281 HOH HOH A . 
H 6 HOH 18  518 37  HOH HOH A . 
H 6 HOH 19  519 82  HOH HOH A . 
H 6 HOH 20  520 10  HOH HOH A . 
H 6 HOH 21  521 179 HOH HOH A . 
H 6 HOH 22  522 205 HOH HOH A . 
H 6 HOH 23  523 20  HOH HOH A . 
H 6 HOH 24  524 6   HOH HOH A . 
H 6 HOH 25  525 110 HOH HOH A . 
H 6 HOH 26  526 199 HOH HOH A . 
H 6 HOH 27  527 46  HOH HOH A . 
H 6 HOH 28  528 160 HOH HOH A . 
H 6 HOH 29  529 269 HOH HOH A . 
H 6 HOH 30  530 72  HOH HOH A . 
H 6 HOH 31  531 125 HOH HOH A . 
H 6 HOH 32  532 31  HOH HOH A . 
H 6 HOH 33  533 33  HOH HOH A . 
H 6 HOH 34  534 301 HOH HOH A . 
H 6 HOH 35  535 156 HOH HOH A . 
H 6 HOH 36  536 76  HOH HOH A . 
H 6 HOH 37  537 25  HOH HOH A . 
H 6 HOH 38  538 93  HOH HOH A . 
H 6 HOH 39  539 221 HOH HOH A . 
H 6 HOH 40  540 182 HOH HOH A . 
H 6 HOH 41  541 232 HOH HOH A . 
H 6 HOH 42  542 102 HOH HOH A . 
H 6 HOH 43  543 222 HOH HOH A . 
H 6 HOH 44  544 121 HOH HOH A . 
H 6 HOH 45  545 26  HOH HOH A . 
H 6 HOH 46  546 324 HOH HOH A . 
H 6 HOH 47  547 96  HOH HOH A . 
H 6 HOH 48  548 55  HOH HOH A . 
H 6 HOH 49  549 86  HOH HOH A . 
H 6 HOH 50  550 57  HOH HOH A . 
H 6 HOH 51  551 29  HOH HOH A . 
H 6 HOH 52  552 66  HOH HOH A . 
H 6 HOH 53  553 2   HOH HOH A . 
H 6 HOH 54  554 181 HOH HOH A . 
H 6 HOH 55  555 118 HOH HOH A . 
H 6 HOH 56  556 95  HOH HOH A . 
H 6 HOH 57  557 49  HOH HOH A . 
H 6 HOH 58  558 99  HOH HOH A . 
H 6 HOH 59  559 13  HOH HOH A . 
H 6 HOH 60  560 177 HOH HOH A . 
H 6 HOH 61  561 52  HOH HOH A . 
H 6 HOH 62  562 175 HOH HOH A . 
H 6 HOH 63  563 24  HOH HOH A . 
H 6 HOH 64  564 41  HOH HOH A . 
H 6 HOH 65  565 190 HOH HOH A . 
H 6 HOH 66  566 297 HOH HOH A . 
H 6 HOH 67  567 135 HOH HOH A . 
H 6 HOH 68  568 189 HOH HOH A . 
H 6 HOH 69  569 18  HOH HOH A . 
H 6 HOH 70  570 345 HOH HOH A . 
H 6 HOH 71  571 165 HOH HOH A . 
H 6 HOH 72  572 141 HOH HOH A . 
H 6 HOH 73  573 87  HOH HOH A . 
H 6 HOH 74  574 28  HOH HOH A . 
H 6 HOH 75  575 144 HOH HOH A . 
H 6 HOH 76  576 11  HOH HOH A . 
H 6 HOH 77  577 234 HOH HOH A . 
H 6 HOH 78  578 36  HOH HOH A . 
H 6 HOH 79  579 315 HOH HOH A . 
H 6 HOH 80  580 150 HOH HOH A . 
H 6 HOH 81  581 30  HOH HOH A . 
H 6 HOH 82  582 314 HOH HOH A . 
H 6 HOH 83  583 263 HOH HOH A . 
H 6 HOH 84  584 139 HOH HOH A . 
H 6 HOH 85  585 79  HOH HOH A . 
H 6 HOH 86  586 149 HOH HOH A . 
H 6 HOH 87  587 169 HOH HOH A . 
H 6 HOH 88  588 12  HOH HOH A . 
H 6 HOH 89  589 151 HOH HOH A . 
H 6 HOH 90  590 211 HOH HOH A . 
H 6 HOH 91  591 94  HOH HOH A . 
H 6 HOH 92  592 71  HOH HOH A . 
H 6 HOH 93  593 60  HOH HOH A . 
H 6 HOH 94  594 38  HOH HOH A . 
H 6 HOH 95  595 341 HOH HOH A . 
H 6 HOH 96  596 51  HOH HOH A . 
H 6 HOH 97  597 286 HOH HOH A . 
H 6 HOH 98  598 68  HOH HOH A . 
H 6 HOH 99  599 111 HOH HOH A . 
H 6 HOH 100 600 114 HOH HOH A . 
H 6 HOH 101 601 240 HOH HOH A . 
H 6 HOH 102 602 136 HOH HOH A . 
H 6 HOH 103 603 294 HOH HOH A . 
H 6 HOH 104 604 14  HOH HOH A . 
H 6 HOH 105 605 83  HOH HOH A . 
H 6 HOH 106 606 176 HOH HOH A . 
H 6 HOH 107 607 220 HOH HOH A . 
H 6 HOH 108 608 17  HOH HOH A . 
H 6 HOH 109 609 253 HOH HOH A . 
H 6 HOH 110 610 245 HOH HOH A . 
H 6 HOH 111 611 132 HOH HOH A . 
H 6 HOH 112 612 74  HOH HOH A . 
H 6 HOH 113 613 73  HOH HOH A . 
H 6 HOH 114 614 155 HOH HOH A . 
H 6 HOH 115 615 78  HOH HOH A . 
H 6 HOH 116 616 147 HOH HOH A . 
H 6 HOH 117 617 163 HOH HOH A . 
H 6 HOH 118 618 292 HOH HOH A . 
H 6 HOH 119 619 334 HOH HOH A . 
H 6 HOH 120 620 159 HOH HOH A . 
H 6 HOH 121 621 231 HOH HOH A . 
H 6 HOH 122 622 187 HOH HOH A . 
H 6 HOH 123 623 321 HOH HOH A . 
H 6 HOH 124 624 180 HOH HOH A . 
H 6 HOH 125 625 117 HOH HOH A . 
H 6 HOH 126 626 154 HOH HOH A . 
H 6 HOH 127 627 126 HOH HOH A . 
H 6 HOH 128 628 89  HOH HOH A . 
H 6 HOH 129 629 339 HOH HOH A . 
H 6 HOH 130 630 213 HOH HOH A . 
H 6 HOH 131 631 106 HOH HOH A . 
H 6 HOH 132 632 103 HOH HOH A . 
H 6 HOH 133 633 104 HOH HOH A . 
H 6 HOH 134 634 247 HOH HOH A . 
H 6 HOH 135 635 134 HOH HOH A . 
H 6 HOH 136 636 109 HOH HOH A . 
H 6 HOH 137 637 335 HOH HOH A . 
H 6 HOH 138 638 43  HOH HOH A . 
H 6 HOH 139 639 293 HOH HOH A . 
H 6 HOH 140 640 59  HOH HOH A . 
H 6 HOH 141 641 171 HOH HOH A . 
H 6 HOH 142 642 167 HOH HOH A . 
H 6 HOH 143 643 203 HOH HOH A . 
H 6 HOH 144 644 306 HOH HOH A . 
H 6 HOH 145 645 168 HOH HOH A . 
H 6 HOH 146 646 170 HOH HOH A . 
H 6 HOH 147 647 188 HOH HOH A . 
H 6 HOH 148 648 295 HOH HOH A . 
H 6 HOH 149 649 107 HOH HOH A . 
I 6 HOH 1   501 214 HOH HOH B . 
I 6 HOH 2   502 340 HOH HOH B . 
I 6 HOH 3   503 239 HOH HOH B . 
I 6 HOH 4   504 258 HOH HOH B . 
I 6 HOH 5   505 323 HOH HOH B . 
I 6 HOH 6   506 196 HOH HOH B . 
I 6 HOH 7   507 193 HOH HOH B . 
I 6 HOH 8   508 210 HOH HOH B . 
I 6 HOH 9   509 131 HOH HOH B . 
I 6 HOH 10  510 296 HOH HOH B . 
I 6 HOH 11  511 228 HOH HOH B . 
I 6 HOH 12  512 34  HOH HOH B . 
I 6 HOH 13  513 35  HOH HOH B . 
I 6 HOH 14  514 174 HOH HOH B . 
I 6 HOH 15  515 91  HOH HOH B . 
I 6 HOH 16  516 122 HOH HOH B . 
I 6 HOH 17  517 62  HOH HOH B . 
I 6 HOH 18  518 75  HOH HOH B . 
I 6 HOH 19  519 21  HOH HOH B . 
I 6 HOH 20  520 270 HOH HOH B . 
I 6 HOH 21  521 223 HOH HOH B . 
I 6 HOH 22  522 280 HOH HOH B . 
I 6 HOH 23  523 217 HOH HOH B . 
I 6 HOH 24  524 227 HOH HOH B . 
I 6 HOH 25  525 225 HOH HOH B . 
I 6 HOH 26  526 4   HOH HOH B . 
I 6 HOH 27  527 256 HOH HOH B . 
I 6 HOH 28  528 202 HOH HOH B . 
I 6 HOH 29  529 53  HOH HOH B . 
I 6 HOH 30  530 9   HOH HOH B . 
I 6 HOH 31  531 112 HOH HOH B . 
I 6 HOH 32  532 58  HOH HOH B . 
I 6 HOH 33  533 195 HOH HOH B . 
I 6 HOH 34  534 92  HOH HOH B . 
I 6 HOH 35  535 115 HOH HOH B . 
I 6 HOH 36  536 332 HOH HOH B . 
I 6 HOH 37  537 140 HOH HOH B . 
I 6 HOH 38  538 344 HOH HOH B . 
I 6 HOH 39  539 209 HOH HOH B . 
I 6 HOH 40  540 194 HOH HOH B . 
I 6 HOH 41  541 200 HOH HOH B . 
I 6 HOH 42  542 238 HOH HOH B . 
I 6 HOH 43  543 50  HOH HOH B . 
I 6 HOH 44  544 192 HOH HOH B . 
I 6 HOH 45  545 208 HOH HOH B . 
I 6 HOH 46  546 39  HOH HOH B . 
I 6 HOH 47  547 42  HOH HOH B . 
I 6 HOH 48  548 265 HOH HOH B . 
I 6 HOH 49  549 123 HOH HOH B . 
I 6 HOH 50  550 19  HOH HOH B . 
I 6 HOH 51  551 148 HOH HOH B . 
I 6 HOH 52  552 16  HOH HOH B . 
I 6 HOH 53  553 268 HOH HOH B . 
I 6 HOH 54  554 138 HOH HOH B . 
I 6 HOH 55  555 251 HOH HOH B . 
I 6 HOH 56  556 284 HOH HOH B . 
I 6 HOH 57  557 1   HOH HOH B . 
I 6 HOH 58  558 44  HOH HOH B . 
I 6 HOH 59  559 48  HOH HOH B . 
I 6 HOH 60  560 127 HOH HOH B . 
I 6 HOH 61  561 120 HOH HOH B . 
I 6 HOH 62  562 8   HOH HOH B . 
I 6 HOH 63  563 252 HOH HOH B . 
I 6 HOH 64  564 313 HOH HOH B . 
I 6 HOH 65  565 215 HOH HOH B . 
I 6 HOH 66  566 22  HOH HOH B . 
I 6 HOH 67  567 142 HOH HOH B . 
I 6 HOH 68  568 275 HOH HOH B . 
I 6 HOH 69  569 172 HOH HOH B . 
I 6 HOH 70  570 304 HOH HOH B . 
I 6 HOH 71  571 84  HOH HOH B . 
I 6 HOH 72  572 70  HOH HOH B . 
I 6 HOH 73  573 54  HOH HOH B . 
I 6 HOH 74  574 67  HOH HOH B . 
I 6 HOH 75  575 342 HOH HOH B . 
I 6 HOH 76  576 162 HOH HOH B . 
I 6 HOH 77  577 145 HOH HOH B . 
I 6 HOH 78  578 100 HOH HOH B . 
I 6 HOH 79  579 27  HOH HOH B . 
I 6 HOH 80  580 56  HOH HOH B . 
I 6 HOH 81  581 216 HOH HOH B . 
I 6 HOH 82  582 319 HOH HOH B . 
I 6 HOH 83  583 32  HOH HOH B . 
I 6 HOH 84  584 242 HOH HOH B . 
I 6 HOH 85  585 274 HOH HOH B . 
I 6 HOH 86  586 243 HOH HOH B . 
I 6 HOH 87  587 248 HOH HOH B . 
I 6 HOH 88  588 108 HOH HOH B . 
I 6 HOH 89  589 250 HOH HOH B . 
I 6 HOH 90  590 327 HOH HOH B . 
I 6 HOH 91  591 310 HOH HOH B . 
I 6 HOH 92  592 23  HOH HOH B . 
I 6 HOH 93  593 15  HOH HOH B . 
I 6 HOH 94  594 316 HOH HOH B . 
I 6 HOH 95  595 161 HOH HOH B . 
I 6 HOH 96  596 337 HOH HOH B . 
I 6 HOH 97  597 204 HOH HOH B . 
I 6 HOH 98  598 197 HOH HOH B . 
I 6 HOH 99  599 101 HOH HOH B . 
I 6 HOH 100 600 80  HOH HOH B . 
I 6 HOH 101 601 299 HOH HOH B . 
I 6 HOH 102 602 198 HOH HOH B . 
I 6 HOH 103 603 98  HOH HOH B . 
I 6 HOH 104 604 287 HOH HOH B . 
I 6 HOH 105 605 85  HOH HOH B . 
I 6 HOH 106 606 312 HOH HOH B . 
I 6 HOH 107 607 90  HOH HOH B . 
I 6 HOH 108 608 219 HOH HOH B . 
I 6 HOH 109 609 267 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8Z2G 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     83.025 
_cell.length_a_esd                 ? 
_cell.length_b                     83.025 
_cell.length_b_esd                 ? 
_cell.length_c                     64.501 
_cell.length_c_esd                 ? 
_cell.volume                       385047.979 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8Z2G 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                143 
_symmetry.space_group_name_Hall            'P 3' 
_symmetry.space_group_name_H-M             'P 3' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8Z2G 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.22 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          44.63 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.13 M Ammonium sulfate, 0.66 M MES pH 6.5, 20% (w/v) PEG monomethyl ether 5,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-05-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL45XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL45XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8Z2G 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.90 
_reflns.d_resolution_low                               48.01 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     39011 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.1 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                0.124 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.90 
_reflns_shell.d_res_low                                     2.01 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.4 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6294 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.2 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.633 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.1 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               0.663 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.14 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8Z2G 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             48.01 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     39006 
_refine.ls_number_reflns_R_free                  1961 
_refine.ls_number_reflns_R_work                  37045 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.12 
_refine.ls_percent_reflns_R_free                 5.03 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2019 
_refine.ls_R_factor_R_free                       0.2028 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1752 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          64.41 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      7CTS 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 35.3033 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        48.01 
_refine_hist.number_atoms_solvent             258 
_refine_hist.number_atoms_total               4319 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4010 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         51 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0023  ? 4172 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5337  ? 5679 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0419  ? 606  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0055  ? 744  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.6528 ? 1540 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.90 1.95  . . 143 2630 93.36 . . . . 0.2789 . . . . . . . . . . . 0.2716 
'X-RAY DIFFRACTION' 1.95 2.00  . . 136 2633 95.02 . . . . 0.2811 . . . . . . . . . . . 0.3438 
'X-RAY DIFFRACTION' 2.00 2.06  . . 142 2674 94.89 . . . . 0.2741 . . . . . . . . . . . 0.3008 
'X-RAY DIFFRACTION' 2.06 2.12  . . 144 2695 94.86 . . . . 0.2702 . . . . . . . . . . . 0.3108 
'X-RAY DIFFRACTION' 2.12 2.20  . . 139 2666 95.04 . . . . 0.2656 . . . . . . . . . . . 0.2721 
'X-RAY DIFFRACTION' 2.20 2.29  . . 146 2676 94.63 . . . . 0.2498 . . . . . . . . . . . 0.3116 
'X-RAY DIFFRACTION' 2.29 2.39  . . 144 2644 94.50 . . . . 0.2373 . . . . . . . . . . . 0.2559 
'X-RAY DIFFRACTION' 2.39 2.52  . . 131 2646 94.70 . . . . 0.2323 . . . . . . . . . . . 0.2564 
'X-RAY DIFFRACTION' 2.52 2.67  . . 138 2662 94.60 . . . . 0.2233 . . . . . . . . . . . 0.2656 
'X-RAY DIFFRACTION' 2.67 2.88  . . 140 2639 94.22 . . . . 0.2065 . . . . . . . . . . . 0.2105 
'X-RAY DIFFRACTION' 2.88 3.17  . . 126 2630 93.30 . . . . 0.1997 . . . . . . . . . . . 0.2363 
'X-RAY DIFFRACTION' 3.17 3.63  . . 142 2636 93.54 . . . . 0.1935 . . . . . . . . . . . 0.1975 
'X-RAY DIFFRACTION' 3.63 4.57  . . 142 2579 91.16 . . . . 0.1517 . . . . . . . . . . . 0.1989 
'X-RAY DIFFRACTION' 4.57 48.01 . . 139 2644 94.43 . . . . 0.1474 . . . . . . . . . . . 0.1883 
# 
_struct.entry_id                     8Z2G 
_struct.title                        'MHET bound form of PET-degrading cutinase mutant Cut190*SS_S176A' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8Z2G 
_struct_keywords.text            'PROTEIN ENGINEERING, POLYESTERASE, METAL BINDING, Aromatic ligand, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 5 ? 
G N N 4 ? 
H N N 6 ? 
I N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    W0TJ64_9PSEU 
_struct_ref.pdbx_db_accession          W0TJ64 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;NPYERGPDPTEDSIEAIRGPFSVATERVSSFASGFGGGTIYYPRETDEGTFGAVAVAPGFTASQGSMSWYGERVASQGFI
VFTIDTNTRLDQPGQRGRQLLAALDYLVERSDRKVRERLDPNRLAVMGHSMGGGGSLEATVMRPSLKASIPLTPWNLDKT
WGQVQVPTFIIGAELDTIASVRTHAKPFYESLPSSLPKAYMELDGATHFAPNIPNTTIAKYVISWLKRFVDEDTRYSQFL
CPNPTDRAIEEYRSTCPY
;
_struct_ref.pdbx_align_begin           47 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8Z2G A 3 ? 260 ? W0TJ64 47 ? 304 ? 47 304 
2 1 8Z2G B 3 ? 260 ? W0TJ64 47 ? 304 ? 47 304 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8Z2G GLY A 1   ? UNP W0TJ64 ?   ?   'expression tag'      45  1  
1 8Z2G PRO A 2   ? UNP W0TJ64 ?   ?   'expression tag'      46  2  
1 8Z2G HIS A 79  ? UNP W0TJ64 GLN 123 'engineered mutation' 123 3  
1 8Z2G ALA A 94  ? UNP W0TJ64 GLN 138 'engineered mutation' 138 4  
1 8Z2G ALA A 132 ? UNP W0TJ64 SER 176 'engineered mutation' 176 5  
1 8Z2G HIS A 158 ? UNP W0TJ64 ASN 202 'engineered mutation' 202 6  
1 8Z2G PRO A 182 ? UNP W0TJ64 SER 226 'engineered mutation' 226 7  
1 8Z2G SER A 184 ? UNP W0TJ64 ARG 228 'engineered mutation' 228 8  
1 8Z2G CYS A 206 ? UNP W0TJ64 ASP 250 'engineered mutation' 250 9  
1 8Z2G CYS A 252 ? UNP W0TJ64 GLU 296 'engineered mutation' 296 10 
1 8Z2G LYS A 261 ? UNP W0TJ64 ?   ?   'expression tag'      305 11 
1 8Z2G LEU A 262 ? UNP W0TJ64 ?   ?   'expression tag'      306 12 
1 8Z2G ASN A 263 ? UNP W0TJ64 ?   ?   'expression tag'      307 13 
2 8Z2G GLY B 1   ? UNP W0TJ64 ?   ?   'expression tag'      45  14 
2 8Z2G PRO B 2   ? UNP W0TJ64 ?   ?   'expression tag'      46  15 
2 8Z2G HIS B 79  ? UNP W0TJ64 GLN 123 'engineered mutation' 123 16 
2 8Z2G ALA B 94  ? UNP W0TJ64 GLN 138 'engineered mutation' 138 17 
2 8Z2G ALA B 132 ? UNP W0TJ64 SER 176 'engineered mutation' 176 18 
2 8Z2G HIS B 158 ? UNP W0TJ64 ASN 202 'engineered mutation' 202 19 
2 8Z2G PRO B 182 ? UNP W0TJ64 SER 226 'engineered mutation' 226 20 
2 8Z2G SER B 184 ? UNP W0TJ64 ARG 228 'engineered mutation' 228 21 
2 8Z2G CYS B 206 ? UNP W0TJ64 ASP 250 'engineered mutation' 250 22 
2 8Z2G CYS B 252 ? UNP W0TJ64 GLU 296 'engineered mutation' 296 23 
2 8Z2G LYS B 261 ? UNP W0TJ64 ?   ?   'expression tag'      305 24 
2 8Z2G LEU B 262 ? UNP W0TJ64 ?   ?   'expression tag'      306 25 
2 8Z2G ASN B 263 ? UNP W0TJ64 ?   ?   'expression tag'      307 26 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,E,H 
2 1 B,F,G,I   
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 12  ? ALA A 18  ? THR A 56  ALA A 62  1 ? 7  
HELX_P HELX_P2  AA2 SER A 65  ? MET A 69  ? SER A 109 MET A 113 5 ? 5  
HELX_P HELX_P3  AA3 SER A 70  ? SER A 78  ? SER A 114 SER A 122 1 ? 9  
HELX_P HELX_P4  AA4 ALA A 94  ? ARG A 112 ? ALA A 138 ARG A 156 1 ? 19 
HELX_P HELX_P5  AA5 ASP A 114 ? GLU A 119 ? ASP A 158 GLU A 163 1 ? 6  
HELX_P HELX_P6  AA6 ALA A 132 ? ARG A 145 ? ALA A 176 ARG A 189 1 ? 14 
HELX_P HELX_P7  AA7 HIS A 186 ? LEU A 194 ? HIS A 230 LEU A 238 1 ? 9  
HELX_P HELX_P8  AA8 PHE A 211 ? ILE A 215 ? PHE A 255 ILE A 259 5 ? 5  
HELX_P HELX_P9  AA9 ASN A 217 ? ASP A 233 ? ASN A 261 ASP A 277 1 ? 17 
HELX_P HELX_P10 AB1 ASP A 235 ? ARG A 237 ? ASP A 279 ARG A 281 5 ? 3  
HELX_P HELX_P11 AB2 TYR A 238 ? CYS A 243 ? TYR A 282 CYS A 287 1 ? 6  
HELX_P HELX_P12 AB3 THR B 12  ? GLU B 17  ? THR B 56  GLU B 61  1 ? 6  
HELX_P HELX_P13 AB4 SER B 65  ? SER B 70  ? SER B 109 SER B 114 5 ? 6  
HELX_P HELX_P14 AB5 TRP B 71  ? SER B 78  ? TRP B 115 SER B 122 1 ? 8  
HELX_P HELX_P15 AB6 ALA B 94  ? ARG B 112 ? ALA B 138 ARG B 156 1 ? 19 
HELX_P HELX_P16 AB7 ASP B 114 ? GLU B 119 ? ASP B 158 GLU B 163 1 ? 6  
HELX_P HELX_P17 AB8 ALA B 132 ? ARG B 145 ? ALA B 176 ARG B 189 1 ? 14 
HELX_P HELX_P18 AB9 HIS B 186 ? LEU B 194 ? HIS B 230 LEU B 238 1 ? 9  
HELX_P HELX_P19 AC1 PHE B 211 ? ILE B 215 ? PHE B 255 ILE B 259 5 ? 5  
HELX_P HELX_P20 AC2 ASN B 217 ? ASP B 233 ? ASN B 261 ASP B 277 1 ? 17 
HELX_P HELX_P21 AC3 ASP B 235 ? ARG B 237 ? ASP B 279 ARG B 281 5 ? 3  
HELX_P HELX_P22 AC4 TYR B 238 ? CYS B 243 ? TYR B 282 CYS B 287 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 206 SG ? ? ? 1_555 A CYS 252 SG ? ? A CYS 250 A CYS 296 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf2 disulf ? ? A CYS 243 SG ? ? ? 1_555 A CYS 258 SG ? ? A CYS 287 A CYS 302 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf3 disulf ? ? B CYS 206 SG ? ? ? 1_555 B CYS 252 SG ? ? B CYS 250 B CYS 296 1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf4 disulf ? ? B CYS 243 SG ? ? ? 1_555 B CYS 258 SG ? ? B CYS 287 B CYS 302 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 206 ? CYS A 252 ? CYS A 250 ? 1_555 CYS A 296 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 243 ? CYS A 258 ? CYS A 287 ? 1_555 CYS A 302 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 206 ? CYS B 252 ? CYS B 250 ? 1_555 CYS B 296 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS B 243 ? CYS B 258 ? CYS B 287 ? 1_555 CYS B 302 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 CYS 243 A . ? CYS 287 A PRO 244 A ? PRO 288 A 1 -1.89 
2 CYS 258 A . ? CYS 302 A PRO 259 A ? PRO 303 A 1 -0.13 
3 CYS 243 B . ? CYS 287 B PRO 244 B ? PRO 288 B 1 -0.11 
4 CYS 258 B . ? CYS 302 B PRO 259 B ? PRO 303 B 1 -1.45 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 3 ? 
AA3 ? 6 ? 
AA4 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA3 4 5 ? parallel      
AA3 5 6 ? parallel      
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 25  ? VAL A 30  ? VAL A 69  VAL A 74  
AA1 2 GLY A 40  ? PRO A 45  ? GLY A 84  PRO A 89  
AA1 3 ILE A 82  ? ILE A 86  ? ILE A 126 ILE A 130 
AA1 4 PHE A 53  ? ALA A 59  ? PHE A 97  ALA A 103 
AA1 5 LEU A 121 ? HIS A 131 ? LEU A 165 HIS A 175 
AA1 6 ALA A 150 ? LEU A 154 ? ALA A 194 LEU A 198 
AA2 1 THR A 170 ? ALA A 175 ? THR A 214 ALA A 219 
AA2 2 LYS A 200 ? LEU A 205 ? LYS A 244 LEU A 249 
AA2 3 ILE A 251 ? SER A 256 ? ILE A 295 SER A 300 
AA3 1 VAL B 25  ? VAL B 30  ? VAL B 69  VAL B 74  
AA3 2 GLY B 40  ? PRO B 45  ? GLY B 84  PRO B 89  
AA3 3 PHE B 81  ? ILE B 86  ? PHE B 125 ILE B 130 
AA3 4 PHE B 53  ? ALA B 59  ? PHE B 97  ALA B 103 
AA3 5 LEU B 121 ? HIS B 131 ? LEU B 165 HIS B 175 
AA3 6 ALA B 150 ? LEU B 154 ? ALA B 194 LEU B 198 
AA4 1 THR B 170 ? ALA B 175 ? THR B 214 ALA B 219 
AA4 2 LYS B 200 ? LEU B 205 ? LYS B 244 LEU B 249 
AA4 3 ILE B 251 ? SER B 256 ? ILE B 295 SER B 300 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 30  ? N VAL A 74  O GLY A 40  ? O GLY A 84  
AA1 2 3 N TYR A 43  ? N TYR A 87  O VAL A 83  ? O VAL A 127 
AA1 3 4 O PHE A 84  ? O PHE A 128 N VAL A 58  ? N VAL A 102 
AA1 4 5 N PHE A 53  ? N PHE A 97  O ASP A 122 ? O ASP A 166 
AA1 5 6 N GLY A 130 ? N GLY A 174 O LEU A 154 ? O LEU A 198 
AA2 1 2 N GLY A 174 ? N GLY A 218 O LEU A 205 ? O LEU A 249 
AA2 2 3 N GLU A 204 ? N GLU A 248 O CYS A 252 ? O CYS A 296 
AA3 1 2 N GLU B 28  ? N GLU B 72  O ILE B 42  ? O ILE B 86  
AA3 2 3 N TYR B 43  ? N TYR B 87  O VAL B 83  ? O VAL B 127 
AA3 3 4 O ILE B 82  ? O ILE B 126 N GLY B 54  ? N GLY B 98  
AA3 4 5 N PHE B 53  ? N PHE B 97  O ASP B 122 ? O ASP B 166 
AA3 5 6 N GLY B 130 ? N GLY B 174 O LEU B 154 ? O LEU B 198 
AA4 1 2 N GLY B 174 ? N GLY B 218 O MET B 203 ? O MET B 247 
AA4 2 3 N TYR B 202 ? N TYR B 246 O ARG B 255 ? O ARG B 299 
# 
_pdbx_entry_details.entry_id                   8Z2G 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 176 ? ? 56.83   -110.90 
2 1 HIS A 230 ? ? -123.06 -78.64  
3 1 PRO A 243 ? ? -65.86  98.27   
4 1 ALA B 176 ? ? 57.56   -111.78 
5 1 HIS B 230 ? ? -124.50 -79.00  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z     
2 -y,x-y,z  
3 -x+y,-x,z 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      B 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       609 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.82 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY 45  ? A GLY 1   
2 1 Y 1 A LYS 305 ? A LYS 261 
3 1 Y 1 A LEU 306 ? A LEU 262 
4 1 Y 1 A ASN 307 ? A ASN 263 
5 1 Y 1 B GLY 45  ? B GLY 1   
6 1 Y 1 B LYS 305 ? B LYS 261 
7 1 Y 1 B LEU 306 ? B LEU 262 
8 1 Y 1 B ASN 307 ? B ASN 263 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
BTB C1   C N N 74  
BTB O1   O N N 75  
BTB C2   C N N 76  
BTB C3   C N N 77  
BTB O3   O N N 78  
BTB C4   C N N 79  
BTB O4   O N N 80  
BTB N    N N N 81  
BTB C5   C N N 82  
BTB C6   C N N 83  
BTB O6   O N N 84  
BTB C7   C N N 85  
BTB C8   C N N 86  
BTB O8   O N N 87  
BTB H11  H N N 88  
BTB H12  H N N 89  
BTB HO1  H N N 90  
BTB H31  H N N 91  
BTB H32  H N N 92  
BTB HO3  H N N 93  
BTB H41  H N N 94  
BTB H42  H N N 95  
BTB HO4  H N N 96  
BTB H51  H N N 97  
BTB H52  H N N 98  
BTB H61  H N N 99  
BTB H62  H N N 100 
BTB HO6  H N N 101 
BTB H71  H N N 102 
BTB H72  H N N 103 
BTB H81  H N N 104 
BTB H82  H N N 105 
BTB HO8  H N N 106 
C9C C2   C N N 107 
C9C C3   C N N 108 
C9C C4   C Y N 109 
C9C C5   C Y N 110 
C9C C6   C Y N 111 
C9C C7   C Y N 112 
C9C C8   C Y N 113 
C9C C1   C N N 114 
C9C O1   O N N 115 
C9C O2   O N N 116 
C9C O3   O N N 117 
C9C C9   C Y N 118 
C9C C10  C N N 119 
C9C O4   O N N 120 
C9C H1   H N N 121 
C9C H2   H N N 122 
C9C H3   H N N 123 
C9C H4   H N N 124 
C9C H5   H N N 125 
C9C H6   H N N 126 
C9C H7   H N N 127 
C9C H8   H N N 128 
C9C H9   H N N 129 
C9C H12  H N N 130 
C9C O5   O N N 131 
CYS N    N N N 132 
CYS CA   C N R 133 
CYS C    C N N 134 
CYS O    O N N 135 
CYS CB   C N N 136 
CYS SG   S N N 137 
CYS OXT  O N N 138 
CYS H    H N N 139 
CYS H2   H N N 140 
CYS HA   H N N 141 
CYS HB2  H N N 142 
CYS HB3  H N N 143 
CYS HG   H N N 144 
CYS HXT  H N N 145 
GLN N    N N N 146 
GLN CA   C N S 147 
GLN C    C N N 148 
GLN O    O N N 149 
GLN CB   C N N 150 
GLN CG   C N N 151 
GLN CD   C N N 152 
GLN OE1  O N N 153 
GLN NE2  N N N 154 
GLN OXT  O N N 155 
GLN H    H N N 156 
GLN H2   H N N 157 
GLN HA   H N N 158 
GLN HB2  H N N 159 
GLN HB3  H N N 160 
GLN HG2  H N N 161 
GLN HG3  H N N 162 
GLN HE21 H N N 163 
GLN HE22 H N N 164 
GLN HXT  H N N 165 
GLU N    N N N 166 
GLU CA   C N S 167 
GLU C    C N N 168 
GLU O    O N N 169 
GLU CB   C N N 170 
GLU CG   C N N 171 
GLU CD   C N N 172 
GLU OE1  O N N 173 
GLU OE2  O N N 174 
GLU OXT  O N N 175 
GLU H    H N N 176 
GLU H2   H N N 177 
GLU HA   H N N 178 
GLU HB2  H N N 179 
GLU HB3  H N N 180 
GLU HG2  H N N 181 
GLU HG3  H N N 182 
GLU HE2  H N N 183 
GLU HXT  H N N 184 
GLY N    N N N 185 
GLY CA   C N N 186 
GLY C    C N N 187 
GLY O    O N N 188 
GLY OXT  O N N 189 
GLY H    H N N 190 
GLY H2   H N N 191 
GLY HA2  H N N 192 
GLY HA3  H N N 193 
GLY HXT  H N N 194 
GOL C1   C N N 195 
GOL O1   O N N 196 
GOL C2   C N N 197 
GOL O2   O N N 198 
GOL C3   C N N 199 
GOL O3   O N N 200 
GOL H11  H N N 201 
GOL H12  H N N 202 
GOL HO1  H N N 203 
GOL H2   H N N 204 
GOL HO2  H N N 205 
GOL H31  H N N 206 
GOL H32  H N N 207 
GOL HO3  H N N 208 
HIS N    N N N 209 
HIS CA   C N S 210 
HIS C    C N N 211 
HIS O    O N N 212 
HIS CB   C N N 213 
HIS CG   C Y N 214 
HIS ND1  N Y N 215 
HIS CD2  C Y N 216 
HIS CE1  C Y N 217 
HIS NE2  N Y N 218 
HIS OXT  O N N 219 
HIS H    H N N 220 
HIS H2   H N N 221 
HIS HA   H N N 222 
HIS HB2  H N N 223 
HIS HB3  H N N 224 
HIS HD1  H N N 225 
HIS HD2  H N N 226 
HIS HE1  H N N 227 
HIS HE2  H N N 228 
HIS HXT  H N N 229 
HOH O    O N N 230 
HOH H1   H N N 231 
HOH H2   H N N 232 
ILE N    N N N 233 
ILE CA   C N S 234 
ILE C    C N N 235 
ILE O    O N N 236 
ILE CB   C N S 237 
ILE CG1  C N N 238 
ILE CG2  C N N 239 
ILE CD1  C N N 240 
ILE OXT  O N N 241 
ILE H    H N N 242 
ILE H2   H N N 243 
ILE HA   H N N 244 
ILE HB   H N N 245 
ILE HG12 H N N 246 
ILE HG13 H N N 247 
ILE HG21 H N N 248 
ILE HG22 H N N 249 
ILE HG23 H N N 250 
ILE HD11 H N N 251 
ILE HD12 H N N 252 
ILE HD13 H N N 253 
ILE HXT  H N N 254 
LEU N    N N N 255 
LEU CA   C N S 256 
LEU C    C N N 257 
LEU O    O N N 258 
LEU CB   C N N 259 
LEU CG   C N N 260 
LEU CD1  C N N 261 
LEU CD2  C N N 262 
LEU OXT  O N N 263 
LEU H    H N N 264 
LEU H2   H N N 265 
LEU HA   H N N 266 
LEU HB2  H N N 267 
LEU HB3  H N N 268 
LEU HG   H N N 269 
LEU HD11 H N N 270 
LEU HD12 H N N 271 
LEU HD13 H N N 272 
LEU HD21 H N N 273 
LEU HD22 H N N 274 
LEU HD23 H N N 275 
LEU HXT  H N N 276 
LYS N    N N N 277 
LYS CA   C N S 278 
LYS C    C N N 279 
LYS O    O N N 280 
LYS CB   C N N 281 
LYS CG   C N N 282 
LYS CD   C N N 283 
LYS CE   C N N 284 
LYS NZ   N N N 285 
LYS OXT  O N N 286 
LYS H    H N N 287 
LYS H2   H N N 288 
LYS HA   H N N 289 
LYS HB2  H N N 290 
LYS HB3  H N N 291 
LYS HG2  H N N 292 
LYS HG3  H N N 293 
LYS HD2  H N N 294 
LYS HD3  H N N 295 
LYS HE2  H N N 296 
LYS HE3  H N N 297 
LYS HZ1  H N N 298 
LYS HZ2  H N N 299 
LYS HZ3  H N N 300 
LYS HXT  H N N 301 
MET N    N N N 302 
MET CA   C N S 303 
MET C    C N N 304 
MET O    O N N 305 
MET CB   C N N 306 
MET CG   C N N 307 
MET SD   S N N 308 
MET CE   C N N 309 
MET OXT  O N N 310 
MET H    H N N 311 
MET H2   H N N 312 
MET HA   H N N 313 
MET HB2  H N N 314 
MET HB3  H N N 315 
MET HG2  H N N 316 
MET HG3  H N N 317 
MET HE1  H N N 318 
MET HE2  H N N 319 
MET HE3  H N N 320 
MET HXT  H N N 321 
NH4 N    N N N 322 
NH4 HN1  H N N 323 
NH4 HN2  H N N 324 
NH4 HN3  H N N 325 
NH4 HN4  H N N 326 
PHE N    N N N 327 
PHE CA   C N S 328 
PHE C    C N N 329 
PHE O    O N N 330 
PHE CB   C N N 331 
PHE CG   C Y N 332 
PHE CD1  C Y N 333 
PHE CD2  C Y N 334 
PHE CE1  C Y N 335 
PHE CE2  C Y N 336 
PHE CZ   C Y N 337 
PHE OXT  O N N 338 
PHE H    H N N 339 
PHE H2   H N N 340 
PHE HA   H N N 341 
PHE HB2  H N N 342 
PHE HB3  H N N 343 
PHE HD1  H N N 344 
PHE HD2  H N N 345 
PHE HE1  H N N 346 
PHE HE2  H N N 347 
PHE HZ   H N N 348 
PHE HXT  H N N 349 
PRO N    N N N 350 
PRO CA   C N S 351 
PRO C    C N N 352 
PRO O    O N N 353 
PRO CB   C N N 354 
PRO CG   C N N 355 
PRO CD   C N N 356 
PRO OXT  O N N 357 
PRO H    H N N 358 
PRO HA   H N N 359 
PRO HB2  H N N 360 
PRO HB3  H N N 361 
PRO HG2  H N N 362 
PRO HG3  H N N 363 
PRO HD2  H N N 364 
PRO HD3  H N N 365 
PRO HXT  H N N 366 
SER N    N N N 367 
SER CA   C N S 368 
SER C    C N N 369 
SER O    O N N 370 
SER CB   C N N 371 
SER OG   O N N 372 
SER OXT  O N N 373 
SER H    H N N 374 
SER H2   H N N 375 
SER HA   H N N 376 
SER HB2  H N N 377 
SER HB3  H N N 378 
SER HG   H N N 379 
SER HXT  H N N 380 
THR N    N N N 381 
THR CA   C N S 382 
THR C    C N N 383 
THR O    O N N 384 
THR CB   C N R 385 
THR OG1  O N N 386 
THR CG2  C N N 387 
THR OXT  O N N 388 
THR H    H N N 389 
THR H2   H N N 390 
THR HA   H N N 391 
THR HB   H N N 392 
THR HG1  H N N 393 
THR HG21 H N N 394 
THR HG22 H N N 395 
THR HG23 H N N 396 
THR HXT  H N N 397 
TRP N    N N N 398 
TRP CA   C N S 399 
TRP C    C N N 400 
TRP O    O N N 401 
TRP CB   C N N 402 
TRP CG   C Y N 403 
TRP CD1  C Y N 404 
TRP CD2  C Y N 405 
TRP NE1  N Y N 406 
TRP CE2  C Y N 407 
TRP CE3  C Y N 408 
TRP CZ2  C Y N 409 
TRP CZ3  C Y N 410 
TRP CH2  C Y N 411 
TRP OXT  O N N 412 
TRP H    H N N 413 
TRP H2   H N N 414 
TRP HA   H N N 415 
TRP HB2  H N N 416 
TRP HB3  H N N 417 
TRP HD1  H N N 418 
TRP HE1  H N N 419 
TRP HE3  H N N 420 
TRP HZ2  H N N 421 
TRP HZ3  H N N 422 
TRP HH2  H N N 423 
TRP HXT  H N N 424 
TYR N    N N N 425 
TYR CA   C N S 426 
TYR C    C N N 427 
TYR O    O N N 428 
TYR CB   C N N 429 
TYR CG   C Y N 430 
TYR CD1  C Y N 431 
TYR CD2  C Y N 432 
TYR CE1  C Y N 433 
TYR CE2  C Y N 434 
TYR CZ   C Y N 435 
TYR OH   O N N 436 
TYR OXT  O N N 437 
TYR H    H N N 438 
TYR H2   H N N 439 
TYR HA   H N N 440 
TYR HB2  H N N 441 
TYR HB3  H N N 442 
TYR HD1  H N N 443 
TYR HD2  H N N 444 
TYR HE1  H N N 445 
TYR HE2  H N N 446 
TYR HH   H N N 447 
TYR HXT  H N N 448 
VAL N    N N N 449 
VAL CA   C N S 450 
VAL C    C N N 451 
VAL O    O N N 452 
VAL CB   C N N 453 
VAL CG1  C N N 454 
VAL CG2  C N N 455 
VAL OXT  O N N 456 
VAL H    H N N 457 
VAL H2   H N N 458 
VAL HA   H N N 459 
VAL HB   H N N 460 
VAL HG11 H N N 461 
VAL HG12 H N N 462 
VAL HG13 H N N 463 
VAL HG21 H N N 464 
VAL HG22 H N N 465 
VAL HG23 H N N 466 
VAL HXT  H N N 467 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
BTB C1  O1   sing N N 70  
BTB C1  C2   sing N N 71  
BTB C1  H11  sing N N 72  
BTB C1  H12  sing N N 73  
BTB O1  HO1  sing N N 74  
BTB C2  C3   sing N N 75  
BTB C2  C4   sing N N 76  
BTB C2  N    sing N N 77  
BTB C3  O3   sing N N 78  
BTB C3  H31  sing N N 79  
BTB C3  H32  sing N N 80  
BTB O3  HO3  sing N N 81  
BTB C4  O4   sing N N 82  
BTB C4  H41  sing N N 83  
BTB C4  H42  sing N N 84  
BTB O4  HO4  sing N N 85  
BTB N   C5   sing N N 86  
BTB N   C7   sing N N 87  
BTB C5  C6   sing N N 88  
BTB C5  H51  sing N N 89  
BTB C5  H52  sing N N 90  
BTB C6  O6   sing N N 91  
BTB C6  H61  sing N N 92  
BTB C6  H62  sing N N 93  
BTB O6  HO6  sing N N 94  
BTB C7  C8   sing N N 95  
BTB C7  H71  sing N N 96  
BTB C7  H72  sing N N 97  
BTB C8  O8   sing N N 98  
BTB C8  H81  sing N N 99  
BTB C8  H82  sing N N 100 
BTB O8  HO8  sing N N 101 
C9C O1  C1   sing N N 102 
C9C C1  C2   sing N N 103 
C9C C2  O2   sing N N 104 
C9C O2  C3   sing N N 105 
C9C O3  C3   doub N N 106 
C9C C3  C4   sing N N 107 
C9C C4  C9   doub Y N 108 
C9C C4  C5   sing Y N 109 
C9C C9  C8   sing Y N 110 
C9C C5  C6   doub Y N 111 
C9C C6  C7   sing Y N 112 
C9C C8  C7   doub Y N 113 
C9C C7  C10  sing N N 114 
C9C C10 O4   sing N N 115 
C9C C2  H1   sing N N 116 
C9C C2  H2   sing N N 117 
C9C C5  H3   sing N N 118 
C9C C6  H4   sing N N 119 
C9C C8  H5   sing N N 120 
C9C C1  H6   sing N N 121 
C9C C1  H7   sing N N 122 
C9C O1  H8   sing N N 123 
C9C C9  H9   sing N N 124 
C9C O4  H12  sing N N 125 
C9C C10 O5   doub N N 126 
CYS N   CA   sing N N 127 
CYS N   H    sing N N 128 
CYS N   H2   sing N N 129 
CYS CA  C    sing N N 130 
CYS CA  CB   sing N N 131 
CYS CA  HA   sing N N 132 
CYS C   O    doub N N 133 
CYS C   OXT  sing N N 134 
CYS CB  SG   sing N N 135 
CYS CB  HB2  sing N N 136 
CYS CB  HB3  sing N N 137 
CYS SG  HG   sing N N 138 
CYS OXT HXT  sing N N 139 
GLN N   CA   sing N N 140 
GLN N   H    sing N N 141 
GLN N   H2   sing N N 142 
GLN CA  C    sing N N 143 
GLN CA  CB   sing N N 144 
GLN CA  HA   sing N N 145 
GLN C   O    doub N N 146 
GLN C   OXT  sing N N 147 
GLN CB  CG   sing N N 148 
GLN CB  HB2  sing N N 149 
GLN CB  HB3  sing N N 150 
GLN CG  CD   sing N N 151 
GLN CG  HG2  sing N N 152 
GLN CG  HG3  sing N N 153 
GLN CD  OE1  doub N N 154 
GLN CD  NE2  sing N N 155 
GLN NE2 HE21 sing N N 156 
GLN NE2 HE22 sing N N 157 
GLN OXT HXT  sing N N 158 
GLU N   CA   sing N N 159 
GLU N   H    sing N N 160 
GLU N   H2   sing N N 161 
GLU CA  C    sing N N 162 
GLU CA  CB   sing N N 163 
GLU CA  HA   sing N N 164 
GLU C   O    doub N N 165 
GLU C   OXT  sing N N 166 
GLU CB  CG   sing N N 167 
GLU CB  HB2  sing N N 168 
GLU CB  HB3  sing N N 169 
GLU CG  CD   sing N N 170 
GLU CG  HG2  sing N N 171 
GLU CG  HG3  sing N N 172 
GLU CD  OE1  doub N N 173 
GLU CD  OE2  sing N N 174 
GLU OE2 HE2  sing N N 175 
GLU OXT HXT  sing N N 176 
GLY N   CA   sing N N 177 
GLY N   H    sing N N 178 
GLY N   H2   sing N N 179 
GLY CA  C    sing N N 180 
GLY CA  HA2  sing N N 181 
GLY CA  HA3  sing N N 182 
GLY C   O    doub N N 183 
GLY C   OXT  sing N N 184 
GLY OXT HXT  sing N N 185 
GOL C1  O1   sing N N 186 
GOL C1  C2   sing N N 187 
GOL C1  H11  sing N N 188 
GOL C1  H12  sing N N 189 
GOL O1  HO1  sing N N 190 
GOL C2  O2   sing N N 191 
GOL C2  C3   sing N N 192 
GOL C2  H2   sing N N 193 
GOL O2  HO2  sing N N 194 
GOL C3  O3   sing N N 195 
GOL C3  H31  sing N N 196 
GOL C3  H32  sing N N 197 
GOL O3  HO3  sing N N 198 
HIS N   CA   sing N N 199 
HIS N   H    sing N N 200 
HIS N   H2   sing N N 201 
HIS CA  C    sing N N 202 
HIS CA  CB   sing N N 203 
HIS CA  HA   sing N N 204 
HIS C   O    doub N N 205 
HIS C   OXT  sing N N 206 
HIS CB  CG   sing N N 207 
HIS CB  HB2  sing N N 208 
HIS CB  HB3  sing N N 209 
HIS CG  ND1  sing Y N 210 
HIS CG  CD2  doub Y N 211 
HIS ND1 CE1  doub Y N 212 
HIS ND1 HD1  sing N N 213 
HIS CD2 NE2  sing Y N 214 
HIS CD2 HD2  sing N N 215 
HIS CE1 NE2  sing Y N 216 
HIS CE1 HE1  sing N N 217 
HIS NE2 HE2  sing N N 218 
HIS OXT HXT  sing N N 219 
HOH O   H1   sing N N 220 
HOH O   H2   sing N N 221 
ILE N   CA   sing N N 222 
ILE N   H    sing N N 223 
ILE N   H2   sing N N 224 
ILE CA  C    sing N N 225 
ILE CA  CB   sing N N 226 
ILE CA  HA   sing N N 227 
ILE C   O    doub N N 228 
ILE C   OXT  sing N N 229 
ILE CB  CG1  sing N N 230 
ILE CB  CG2  sing N N 231 
ILE CB  HB   sing N N 232 
ILE CG1 CD1  sing N N 233 
ILE CG1 HG12 sing N N 234 
ILE CG1 HG13 sing N N 235 
ILE CG2 HG21 sing N N 236 
ILE CG2 HG22 sing N N 237 
ILE CG2 HG23 sing N N 238 
ILE CD1 HD11 sing N N 239 
ILE CD1 HD12 sing N N 240 
ILE CD1 HD13 sing N N 241 
ILE OXT HXT  sing N N 242 
LEU N   CA   sing N N 243 
LEU N   H    sing N N 244 
LEU N   H2   sing N N 245 
LEU CA  C    sing N N 246 
LEU CA  CB   sing N N 247 
LEU CA  HA   sing N N 248 
LEU C   O    doub N N 249 
LEU C   OXT  sing N N 250 
LEU CB  CG   sing N N 251 
LEU CB  HB2  sing N N 252 
LEU CB  HB3  sing N N 253 
LEU CG  CD1  sing N N 254 
LEU CG  CD2  sing N N 255 
LEU CG  HG   sing N N 256 
LEU CD1 HD11 sing N N 257 
LEU CD1 HD12 sing N N 258 
LEU CD1 HD13 sing N N 259 
LEU CD2 HD21 sing N N 260 
LEU CD2 HD22 sing N N 261 
LEU CD2 HD23 sing N N 262 
LEU OXT HXT  sing N N 263 
LYS N   CA   sing N N 264 
LYS N   H    sing N N 265 
LYS N   H2   sing N N 266 
LYS CA  C    sing N N 267 
LYS CA  CB   sing N N 268 
LYS CA  HA   sing N N 269 
LYS C   O    doub N N 270 
LYS C   OXT  sing N N 271 
LYS CB  CG   sing N N 272 
LYS CB  HB2  sing N N 273 
LYS CB  HB3  sing N N 274 
LYS CG  CD   sing N N 275 
LYS CG  HG2  sing N N 276 
LYS CG  HG3  sing N N 277 
LYS CD  CE   sing N N 278 
LYS CD  HD2  sing N N 279 
LYS CD  HD3  sing N N 280 
LYS CE  NZ   sing N N 281 
LYS CE  HE2  sing N N 282 
LYS CE  HE3  sing N N 283 
LYS NZ  HZ1  sing N N 284 
LYS NZ  HZ2  sing N N 285 
LYS NZ  HZ3  sing N N 286 
LYS OXT HXT  sing N N 287 
MET N   CA   sing N N 288 
MET N   H    sing N N 289 
MET N   H2   sing N N 290 
MET CA  C    sing N N 291 
MET CA  CB   sing N N 292 
MET CA  HA   sing N N 293 
MET C   O    doub N N 294 
MET C   OXT  sing N N 295 
MET CB  CG   sing N N 296 
MET CB  HB2  sing N N 297 
MET CB  HB3  sing N N 298 
MET CG  SD   sing N N 299 
MET CG  HG2  sing N N 300 
MET CG  HG3  sing N N 301 
MET SD  CE   sing N N 302 
MET CE  HE1  sing N N 303 
MET CE  HE2  sing N N 304 
MET CE  HE3  sing N N 305 
MET OXT HXT  sing N N 306 
NH4 N   HN1  sing N N 307 
NH4 N   HN2  sing N N 308 
NH4 N   HN3  sing N N 309 
NH4 N   HN4  sing N N 310 
PHE N   CA   sing N N 311 
PHE N   H    sing N N 312 
PHE N   H2   sing N N 313 
PHE CA  C    sing N N 314 
PHE CA  CB   sing N N 315 
PHE CA  HA   sing N N 316 
PHE C   O    doub N N 317 
PHE C   OXT  sing N N 318 
PHE CB  CG   sing N N 319 
PHE CB  HB2  sing N N 320 
PHE CB  HB3  sing N N 321 
PHE CG  CD1  doub Y N 322 
PHE CG  CD2  sing Y N 323 
PHE CD1 CE1  sing Y N 324 
PHE CD1 HD1  sing N N 325 
PHE CD2 CE2  doub Y N 326 
PHE CD2 HD2  sing N N 327 
PHE CE1 CZ   doub Y N 328 
PHE CE1 HE1  sing N N 329 
PHE CE2 CZ   sing Y N 330 
PHE CE2 HE2  sing N N 331 
PHE CZ  HZ   sing N N 332 
PHE OXT HXT  sing N N 333 
PRO N   CA   sing N N 334 
PRO N   CD   sing N N 335 
PRO N   H    sing N N 336 
PRO CA  C    sing N N 337 
PRO CA  CB   sing N N 338 
PRO CA  HA   sing N N 339 
PRO C   O    doub N N 340 
PRO C   OXT  sing N N 341 
PRO CB  CG   sing N N 342 
PRO CB  HB2  sing N N 343 
PRO CB  HB3  sing N N 344 
PRO CG  CD   sing N N 345 
PRO CG  HG2  sing N N 346 
PRO CG  HG3  sing N N 347 
PRO CD  HD2  sing N N 348 
PRO CD  HD3  sing N N 349 
PRO OXT HXT  sing N N 350 
SER N   CA   sing N N 351 
SER N   H    sing N N 352 
SER N   H2   sing N N 353 
SER CA  C    sing N N 354 
SER CA  CB   sing N N 355 
SER CA  HA   sing N N 356 
SER C   O    doub N N 357 
SER C   OXT  sing N N 358 
SER CB  OG   sing N N 359 
SER CB  HB2  sing N N 360 
SER CB  HB3  sing N N 361 
SER OG  HG   sing N N 362 
SER OXT HXT  sing N N 363 
THR N   CA   sing N N 364 
THR N   H    sing N N 365 
THR N   H2   sing N N 366 
THR CA  C    sing N N 367 
THR CA  CB   sing N N 368 
THR CA  HA   sing N N 369 
THR C   O    doub N N 370 
THR C   OXT  sing N N 371 
THR CB  OG1  sing N N 372 
THR CB  CG2  sing N N 373 
THR CB  HB   sing N N 374 
THR OG1 HG1  sing N N 375 
THR CG2 HG21 sing N N 376 
THR CG2 HG22 sing N N 377 
THR CG2 HG23 sing N N 378 
THR OXT HXT  sing N N 379 
TRP N   CA   sing N N 380 
TRP N   H    sing N N 381 
TRP N   H2   sing N N 382 
TRP CA  C    sing N N 383 
TRP CA  CB   sing N N 384 
TRP CA  HA   sing N N 385 
TRP C   O    doub N N 386 
TRP C   OXT  sing N N 387 
TRP CB  CG   sing N N 388 
TRP CB  HB2  sing N N 389 
TRP CB  HB3  sing N N 390 
TRP CG  CD1  doub Y N 391 
TRP CG  CD2  sing Y N 392 
TRP CD1 NE1  sing Y N 393 
TRP CD1 HD1  sing N N 394 
TRP CD2 CE2  doub Y N 395 
TRP CD2 CE3  sing Y N 396 
TRP NE1 CE2  sing Y N 397 
TRP NE1 HE1  sing N N 398 
TRP CE2 CZ2  sing Y N 399 
TRP CE3 CZ3  doub Y N 400 
TRP CE3 HE3  sing N N 401 
TRP CZ2 CH2  doub Y N 402 
TRP CZ2 HZ2  sing N N 403 
TRP CZ3 CH2  sing Y N 404 
TRP CZ3 HZ3  sing N N 405 
TRP CH2 HH2  sing N N 406 
TRP OXT HXT  sing N N 407 
TYR N   CA   sing N N 408 
TYR N   H    sing N N 409 
TYR N   H2   sing N N 410 
TYR CA  C    sing N N 411 
TYR CA  CB   sing N N 412 
TYR CA  HA   sing N N 413 
TYR C   O    doub N N 414 
TYR C   OXT  sing N N 415 
TYR CB  CG   sing N N 416 
TYR CB  HB2  sing N N 417 
TYR CB  HB3  sing N N 418 
TYR CG  CD1  doub Y N 419 
TYR CG  CD2  sing Y N 420 
TYR CD1 CE1  sing Y N 421 
TYR CD1 HD1  sing N N 422 
TYR CD2 CE2  doub Y N 423 
TYR CD2 HD2  sing N N 424 
TYR CE1 CZ   doub Y N 425 
TYR CE1 HE1  sing N N 426 
TYR CE2 CZ   sing Y N 427 
TYR CE2 HE2  sing N N 428 
TYR CZ  OH   sing N N 429 
TYR OH  HH   sing N N 430 
TYR OXT HXT  sing N N 431 
VAL N   CA   sing N N 432 
VAL N   H    sing N N 433 
VAL N   H2   sing N N 434 
VAL CA  C    sing N N 435 
VAL CA  CB   sing N N 436 
VAL CA  HA   sing N N 437 
VAL C   O    doub N N 438 
VAL C   OXT  sing N N 439 
VAL CB  CG1  sing N N 440 
VAL CB  CG2  sing N N 441 
VAL CB  HB   sing N N 442 
VAL CG1 HG11 sing N N 443 
VAL CG1 HG12 sing N N 444 
VAL CG1 HG13 sing N N 445 
VAL CG2 HG21 sing N N 446 
VAL CG2 HG22 sing N N 447 
VAL CG2 HG23 sing N N 448 
VAL OXT HXT  sing N N 449 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           JP21H02120 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7cts 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 3' 
_space_group.name_Hall        'P 3' 
_space_group.IT_number        143 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8Z2G 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012045 
_atom_sites.fract_transf_matrix[1][2]   0.006954 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013908 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.015504 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PRO A 1 2   ? 41.84700 44.70800 -21.28700 1.000 49.14000 ? 46  PRO A N   1 
ATOM   2    C CA  . PRO A 1 2   ? 42.13500 44.10100 -19.98300 1.000 45.57000 ? 46  PRO A CA  1 
ATOM   3    C C   . PRO A 1 2   ? 43.61100 44.18900 -19.61100 1.000 42.09000 ? 46  PRO A C   1 
ATOM   4    O O   . PRO A 1 2   ? 44.47400 43.77200 -20.38400 1.000 41.65000 ? 46  PRO A O   1 
ATOM   5    C CB  . PRO A 1 2   ? 41.70500 42.64400 -20.17200 1.000 48.07000 ? 46  PRO A CB  1 
ATOM   6    C CG  . PRO A 1 2   ? 41.83200 42.40400 -21.63500 1.000 52.51000 ? 46  PRO A CG  1 
ATOM   7    C CD  . PRO A 1 2   ? 41.46500 43.70200 -22.29300 1.000 50.04000 ? 46  PRO A CD  1 
ATOM   8    N N   . ASN A 1 3   ? 43.89000 44.73800 -18.43600 1.000 40.03000 ? 47  ASN A N   1 
ATOM   9    C CA  . ASN A 1 3   ? 45.26300 44.86500 -17.96400 1.000 39.22000 ? 47  ASN A CA  1 
ATOM   10   C C   . ASN A 1 3   ? 45.76100 43.51000 -17.47900 1.000 35.16000 ? 47  ASN A C   1 
ATOM   11   O O   . ASN A 1 3   ? 45.15900 42.93200 -16.56600 1.000 35.10000 ? 47  ASN A O   1 
ATOM   12   C CB  . ASN A 1 3   ? 45.34200 45.89600 -16.84400 1.000 34.97000 ? 47  ASN A CB  1 
ATOM   13   C CG  . ASN A 1 3   ? 46.77100 46.25100 -16.45900 1.000 33.22000 ? 47  ASN A CG  1 
ATOM   14   O OD1 . ASN A 1 3   ? 47.72000 45.53800 -16.78500 1.000 33.01000 ? 47  ASN A OD1 1 
ATOM   15   N ND2 . ASN A 1 3   ? 46.92500 47.36200 -15.75000 1.000 33.08000 ? 47  ASN A ND2 1 
ATOM   16   N N   . PRO A 1 4   ? 46.84000 42.96900 -18.05200 1.000 33.84000 ? 48  PRO A N   1 
ATOM   17   C CA  . PRO A 1 4   ? 47.35400 41.67200 -17.58300 1.000 33.55000 ? 48  PRO A CA  1 
ATOM   18   C C   . PRO A 1 4   ? 47.95500 41.71200 -16.18600 1.000 34.05000 ? 48  PRO A C   1 
ATOM   19   O O   . PRO A 1 4   ? 48.28900 40.64700 -15.65000 1.000 32.14000 ? 48  PRO A O   1 
ATOM   20   C CB  . PRO A 1 4   ? 48.41900 41.32000 -18.63100 1.000 33.58000 ? 48  PRO A CB  1 
ATOM   21   C CG  . PRO A 1 4   ? 48.84700 42.64200 -19.18600 1.000 30.96000 ? 48  PRO A CG  1 
ATOM   22   C CD  . PRO A 1 4   ? 47.61000 43.49100 -19.19400 1.000 32.38000 ? 48  PRO A CD  1 
ATOM   23   N N   . TYR A 1 5   ? 48.09800 42.89100 -15.58000 1.000 34.31000 ? 49  TYR A N   1 
ATOM   24   C CA  . TYR A 1 5   ? 48.72000 43.02800 -14.27000 1.000 30.75000 ? 49  TYR A CA  1 
ATOM   25   C C   . TYR A 1 5   ? 47.73400 43.38400 -13.16700 1.000 30.48000 ? 49  TYR A C   1 
ATOM   26   O O   . TYR A 1 5   ? 48.13900 43.47800 -12.00400 1.000 30.03000 ? 49  TYR A O   1 
ATOM   27   C CB  . TYR A 1 5   ? 49.82600 44.09000 -14.31700 1.000 30.41000 ? 49  TYR A CB  1 
ATOM   28   C CG  . TYR A 1 5   ? 50.81100 43.92000 -15.44900 1.000 29.66000 ? 49  TYR A CG  1 
ATOM   29   C CD1 . TYR A 1 5   ? 51.28200 42.66400 -15.80700 1.000 30.67000 ? 49  TYR A CD1 1 
ATOM   30   C CD2 . TYR A 1 5   ? 51.26700 45.01900 -16.16300 1.000 31.43000 ? 49  TYR A CD2 1 
ATOM   31   C CE1 . TYR A 1 5   ? 52.18400 42.50900 -16.84300 1.000 30.05000 ? 49  TYR A CE1 1 
ATOM   32   C CE2 . TYR A 1 5   ? 52.16600 44.87400 -17.19900 1.000 35.32000 ? 49  TYR A CE2 1 
ATOM   33   C CZ  . TYR A 1 5   ? 52.62100 43.61800 -17.53600 1.000 31.91000 ? 49  TYR A CZ  1 
ATOM   34   O OH  . TYR A 1 5   ? 53.51800 43.47200 -18.56900 1.000 33.35000 ? 49  TYR A OH  1 
ATOM   35   N N   . GLU A 1 6   ? 46.46000 43.59300 -13.49200 1.000 32.15000 ? 50  GLU A N   1 
ATOM   36   C CA  . GLU A 1 6   ? 45.48500 43.97700 -12.47800 1.000 29.82000 ? 50  GLU A CA  1 
ATOM   37   C C   . GLU A 1 6   ? 45.17800 42.80300 -11.55800 1.000 31.28000 ? 50  GLU A C   1 
ATOM   38   O O   . GLU A 1 6   ? 44.86000 41.70200 -12.01700 1.000 30.83000 ? 50  GLU A O   1 
ATOM   39   C CB  . GLU A 1 6   ? 44.20200 44.48600 -13.13200 1.000 29.91000 ? 50  GLU A CB  1 
ATOM   40   C CG  . GLU A 1 6   ? 44.26100 45.94900 -13.53400 1.000 32.93000 ? 50  GLU A CG  1 
ATOM   41   C CD  . GLU A 1 6   ? 42.97200 46.44500 -14.16300 1.000 32.05000 ? 50  GLU A CD  1 
ATOM   42   O OE1 . GLU A 1 6   ? 41.94700 45.73600 -14.07300 1.000 26.96000 ? 50  GLU A OE1 1 
ATOM   43   O OE2 . GLU A 1 6   ? 42.98600 47.54800 -14.74900 1.000 34.00000 ? 50  GLU A OE2 1 
ATOM   44   N N   . ARG A 1 7   ? 45.27500 43.04600 -10.25300 1.000 32.12000 ? 51  ARG A N   1 
ATOM   45   C CA  . ARG A 1 7   ? 45.01000 42.04200 -9.23600  1.000 29.87000 ? 51  ARG A CA  1 
ATOM   46   C C   . ARG A 1 7   ? 44.02200 42.60000 -8.22300  1.000 29.05000 ? 51  ARG A C   1 
ATOM   47   O O   . ARG A 1 7   ? 44.01800 43.79900 -7.93200  1.000 30.15000 ? 51  ARG A O   1 
ATOM   48   C CB  . ARG A 1 7   ? 46.29900 41.61300 -8.52000  1.000 30.61000 ? 51  ARG A CB  1 
ATOM   49   C CG  . ARG A 1 7   ? 47.45500 41.26700 -9.44700  1.000 27.48000 ? 51  ARG A CG  1 
ATOM   50   C CD  . ARG A 1 7   ? 47.27500 39.90500 -10.09500 1.000 27.81000 ? 51  ARG A CD  1 
ATOM   51   N NE  . ARG A 1 7   ? 48.40300 39.56500 -10.95500 1.000 31.04000 ? 51  ARG A NE  1 
ATOM   52   C CZ  . ARG A 1 7   ? 48.42000 39.73500 -12.27000 1.000 29.79000 ? 51  ARG A CZ  1 
ATOM   53   N NH1 . ARG A 1 7   ? 47.37300 40.21500 -12.91800 1.000 29.70000 ? 51  ARG A NH1 1 
ATOM   54   N NH2 . ARG A 1 7   ? 49.51600 39.41100 -12.95100 1.000 27.44000 ? 51  ARG A NH2 1 
ATOM   55   N N   . GLY A 1 8   ? 43.18200 41.71800 -7.68800  1.000 28.93000 ? 52  GLY A N   1 
ATOM   56   C CA  . GLY A 1 8   ? 42.22900 42.09700 -6.67300  1.000 30.97000 ? 52  GLY A CA  1 
ATOM   57   C C   . GLY A 1 8   ? 40.99100 42.75700 -7.24500  1.000 29.35000 ? 52  GLY A C   1 
ATOM   58   O O   . GLY A 1 8   ? 40.95500 43.16300 -8.41100  1.000 29.60000 ? 52  GLY A O   1 
ATOM   59   N N   . PRO A 1 9   ? 39.94400 42.87500 -6.42500  1.000 29.07000 ? 53  PRO A N   1 
ATOM   60   C CA  . PRO A 1 9   ? 38.69900 43.49400 -6.90000  1.000 28.32000 ? 53  PRO A CA  1 
ATOM   61   C C   . PRO A 1 9   ? 38.85100 44.98100 -7.17300  1.000 27.38000 ? 53  PRO A C   1 
ATOM   62   O O   . PRO A 1 9   ? 39.91400 45.56100 -6.92600  1.000 28.69000 ? 53  PRO A O   1 
ATOM   63   C CB  . PRO A 1 9   ? 37.71500 43.23600 -5.75000  1.000 28.45000 ? 53  PRO A CB  1 
ATOM   64   C CG  . PRO A 1 9   ? 38.32400 42.12300 -4.95400  1.000 28.99000 ? 53  PRO A CG  1 
ATOM   65   C CD  . PRO A 1 9   ? 39.80200 42.32000 -5.07000  1.000 30.30000 ? 53  PRO A CD  1 
ATOM   66   N N   . ASP A 1 10  ? 37.79300 45.60300 -7.68400  1.000 26.74000 ? 54  ASP A N   1 
ATOM   67   C CA  . ASP A 1 10  ? 37.82500 47.03400 -7.94200  1.000 28.18000 ? 54  ASP A CA  1 
ATOM   68   C C   . ASP A 1 10  ? 37.96000 47.79100 -6.62400  1.000 26.89000 ? 54  ASP A C   1 
ATOM   69   O O   . ASP A 1 10  ? 37.17100 47.56000 -5.69700  1.000 28.15000 ? 54  ASP A O   1 
ATOM   70   C CB  . ASP A 1 10  ? 36.56700 47.48200 -8.68400  1.000 30.67000 ? 54  ASP A CB  1 
ATOM   71   C CG  . ASP A 1 10  ? 36.52700 46.99000 -10.11700 1.000 26.65000 ? 54  ASP A CG  1 
ATOM   72   O OD1 . ASP A 1 10  ? 37.60500 46.73300 -10.69200 1.000 23.76000 ? 54  ASP A OD1 1 
ATOM   73   O OD2 . ASP A 1 10  ? 35.41400 46.86400 -10.66800 1.000 28.94000 ? 54  ASP A OD2 1 
ATOM   74   N N   . PRO A 1 11  ? 38.92600 48.69200 -6.50200  1.000 27.79000 ? 55  PRO A N   1 
ATOM   75   C CA  . PRO A 1 11  ? 39.19300 49.32300 -5.20900  1.000 27.76000 ? 55  PRO A CA  1 
ATOM   76   C C   . PRO A 1 11  ? 38.25100 50.47700 -4.90700  1.000 29.37000 ? 55  PRO A C   1 
ATOM   77   O O   . PRO A 1 11  ? 37.69800 51.12300 -5.80000  1.000 28.67000 ? 55  PRO A O   1 
ATOM   78   C CB  . PRO A 1 11  ? 40.63000 49.82800 -5.36600  1.000 25.99000 ? 55  PRO A CB  1 
ATOM   79   C CG  . PRO A 1 11  ? 40.72200 50.15900 -6.82200  1.000 27.41000 ? 55  PRO A CG  1 
ATOM   80   C CD  . PRO A 1 11  ? 39.88400 49.12300 -7.53500  1.000 27.83000 ? 55  PRO A CD  1 
ATOM   81   N N   . THR A 1 12  ? 38.07800 50.72200 -3.61400  1.000 25.29000 ? 56  THR A N   1 
ATOM   82   C CA  . THR A 1 12  ? 37.44000 51.91900 -3.09400  1.000 23.31000 ? 56  THR A CA  1 
ATOM   83   C C   . THR A 1 12  ? 38.41000 52.60700 -2.14300  1.000 23.12000 ? 56  THR A C   1 
ATOM   84   O O   . THR A 1 12  ? 39.47800 52.07800 -1.82300  1.000 23.57000 ? 56  THR A O   1 
ATOM   85   C CB  . THR A 1 12  ? 36.12800 51.58800 -2.37000  1.000 23.26000 ? 56  THR A CB  1 
ATOM   86   O OG1 . THR A 1 12  ? 36.41100 50.82800 -1.18900  1.000 25.40000 ? 56  THR A OG1 1 
ATOM   87   C CG2 . THR A 1 12  ? 35.20900 50.78200 -3.27200  1.000 25.80000 ? 56  THR A CG2 1 
ATOM   88   N N   . GLU A 1 13  ? 38.03500 53.80500 -1.68900  1.000 24.31000 ? 57  GLU A N   1 
ATOM   89   C CA  . GLU A 1 13  ? 38.85100 54.47600 -0.68300  1.000 24.89000 ? 57  GLU A CA  1 
ATOM   90   C C   . GLU A 1 13  ? 38.87800 53.68500 0.61700   1.000 24.92000 ? 57  GLU A C   1 
ATOM   91   O O   . GLU A 1 13  ? 39.86300 53.74200 1.36100   1.000 26.64000 ? 57  GLU A O   1 
ATOM   92   C CB  . GLU A 1 13  ? 38.33200 55.89300 -0.43800  1.000 24.66000 ? 57  GLU A CB  1 
ATOM   93   C CG  . GLU A 1 13  ? 39.28900 56.77000 0.35300   1.000 26.07000 ? 57  GLU A CG  1 
ATOM   94   C CD  . GLU A 1 13  ? 38.82700 58.20900 0.42900   1.000 24.80000 ? 57  GLU A CD  1 
ATOM   95   O OE1 . GLU A 1 13  ? 37.64200 58.46300 0.13000   1.000 25.72000 ? 57  GLU A OE1 1 
ATOM   96   O OE2 . GLU A 1 13  ? 39.64800 59.08300 0.78000   1.000 25.47000 ? 57  GLU A OE2 1 
ATOM   97   N N   . ASP A 1 14  ? 37.81300 52.93200 0.89600   1.000 25.71000 ? 58  ASP A N   1 
ATOM   98   C CA  . ASP A 1 14  ? 37.79000 52.07500 2.07500   1.000 25.27000 ? 58  ASP A CA  1 
ATOM   99   C C   . ASP A 1 14  ? 38.75800 50.90700 1.92600   1.000 25.06000 ? 58  ASP A C   1 
ATOM   100  O O   . ASP A 1 14  ? 39.39500 50.49200 2.90100   1.000 25.91000 ? 58  ASP A O   1 
ATOM   101  C CB  . ASP A 1 14  ? 36.36600 51.57300 2.31900   1.000 25.60000 ? 58  ASP A CB  1 
ATOM   102  C CG  . ASP A 1 14  ? 36.18000 50.98100 3.70200   1.000 27.42000 ? 58  ASP A CG  1 
ATOM   103  O OD1 . ASP A 1 14  ? 36.27100 51.73800 4.69100   1.000 28.87000 ? 58  ASP A OD1 1 
ATOM   104  O OD2 . ASP A 1 14  ? 35.92900 49.76100 3.79900   1.000 28.23000 ? 58  ASP A OD2 1 
ATOM   105  N N   . SER A 1 15  ? 38.88900 50.36900 0.71000   1.000 25.30000 ? 59  SER A N   1 
ATOM   106  C CA  . SER A 1 15  ? 39.75000 49.20800 0.50400   1.000 23.64000 ? 59  SER A CA  1 
ATOM   107  C C   . SER A 1 15  ? 41.22200 49.57900 0.61700   1.000 24.43000 ? 59  SER A C   1 
ATOM   108  O O   . SER A 1 15  ? 42.02100 48.80800 1.16200   1.000 25.23000 ? 59  SER A O   1 
ATOM   109  C CB  . SER A 1 15  ? 39.46500 48.57400 -0.85600  1.000 25.23000 ? 59  SER A CB  1 
ATOM   110  O OG  . SER A 1 15  ? 39.81600 49.45200 -1.91100  1.000 23.90000 ? 59  SER A OG  1 
ATOM   111  N N   . ILE A 1 16  ? 41.60500 50.74900 0.09800   1.000 24.20000 ? 60  ILE A N   1 
ATOM   112  C CA  . ILE A 1 16  ? 42.99900 51.16600 0.18400   1.000 24.50000 ? 60  ILE A CA  1 
ATOM   113  C C   . ILE A 1 16  ? 43.34900 51.63400 1.58800   1.000 23.35000 ? 60  ILE A C   1 
ATOM   114  O O   . ILE A 1 16  ? 44.52900 51.65500 1.95500   1.000 22.48000 ? 60  ILE A O   1 
ATOM   115  C CB  . ILE A 1 16  ? 43.30900 52.26300 -0.85200  1.000 22.37000 ? 60  ILE A CB  1 
ATOM   116  C CG1 . ILE A 1 16  ? 42.54000 53.54500 -0.52600  1.000 22.71000 ? 60  ILE A CG1 1 
ATOM   117  C CG2 . ILE A 1 16  ? 42.99000 51.76900 -2.25700  1.000 22.72000 ? 60  ILE A CG2 1 
ATOM   118  C CD1 . ILE A 1 16  ? 42.90000 54.71800 -1.41800  1.000 20.92000 ? 60  ILE A CD1 1 
ATOM   119  N N   . GLU A 1 17  ? 42.35200 52.00900 2.38800   1.000 23.40000 ? 61  GLU A N   1 
ATOM   120  C CA  . GLU A 1 17  ? 42.58200 52.37800 3.77600   1.000 23.69000 ? 61  GLU A CA  1 
ATOM   121  C C   . GLU A 1 17  ? 42.54700 51.18600 4.72200   1.000 23.94000 ? 61  GLU A C   1 
ATOM   122  O O   . GLU A 1 17  ? 43.03800 51.29700 5.85100   1.000 26.53000 ? 61  GLU A O   1 
ATOM   123  C CB  . GLU A 1 17  ? 41.54500 53.40800 4.22900   1.000 23.80000 ? 61  GLU A CB  1 
ATOM   124  C CG  . GLU A 1 17  ? 41.76500 54.81000 3.68800   1.000 24.22000 ? 61  GLU A CG  1 
ATOM   125  C CD  . GLU A 1 17  ? 40.81300 55.81200 4.30800   1.000 27.23000 ? 61  GLU A CD  1 
ATOM   126  O OE1 . GLU A 1 17  ? 39.78200 55.37700 4.86100   1.000 29.54000 ? 61  GLU A OE1 1 
ATOM   127  O OE2 . GLU A 1 17  ? 41.09700 57.02700 4.25400   1.000 26.65000 ? 61  GLU A OE2 1 
ATOM   128  N N   . ALA A 1 18  ? 41.99000 50.05500 4.29000   1.000 23.22000 ? 62  ALA A N   1 
ATOM   129  C CA  . ALA A 1 18  ? 41.87200 48.89700 5.16600   1.000 24.66000 ? 62  ALA A CA  1 
ATOM   130  C C   . ALA A 1 18  ? 43.24700 48.37300 5.56000   1.000 24.98000 ? 62  ALA A C   1 
ATOM   131  O O   . ALA A 1 18  ? 44.19100 48.39200 4.76600   1.000 25.28000 ? 62  ALA A O   1 
ATOM   132  C CB  . ALA A 1 18  ? 41.06600 47.79100 4.48500   1.000 25.11000 ? 62  ALA A CB  1 
ATOM   133  N N   . ILE A 1 19  ? 43.35300 47.90300 6.80500   1.000 25.88000 ? 63  ILE A N   1 
ATOM   134  C CA  . ILE A 1 19  ? 44.62300 47.38000 7.29700   1.000 24.41000 ? 63  ILE A CA  1 
ATOM   135  C C   . ILE A 1 19  ? 44.99700 46.09400 6.57400   1.000 23.91000 ? 63  ILE A C   1 
ATOM   136  O O   . ILE A 1 19  ? 46.18200 45.82300 6.34200   1.000 24.19000 ? 63  ILE A O   1 
ATOM   137  C CB  . ILE A 1 19  ? 44.54900 47.18300 8.82300   1.000 25.76000 ? 63  ILE A CB  1 
ATOM   138  C CG1 . ILE A 1 19  ? 44.43400 48.54000 9.52000   1.000 25.94000 ? 63  ILE A CG1 1 
ATOM   139  C CG2 . ILE A 1 19  ? 45.75800 46.41600 9.33600   1.000 25.67000 ? 63  ILE A CG2 1 
ATOM   140  C CD1 . ILE A 1 19  ? 44.47400 48.45900 11.02600  1.000 31.32000 ? 63  ILE A CD1 1 
ATOM   141  N N   . ARG A 1 20  ? 44.01100 45.29100 6.19000   1.000 26.63000 ? 64  ARG A N   1 
ATOM   142  C CA  . ARG A 1 20  ? 44.25200 44.03900 5.48800   1.000 27.94000 ? 64  ARG A CA  1 
ATOM   143  C C   . ARG A 1 20  ? 43.61000 44.09400 4.11100   1.000 27.17000 ? 64  ARG A C   1 
ATOM   144  O O   . ARG A 1 20  ? 42.44600 44.48600 3.97800   1.000 29.94000 ? 64  ARG A O   1 
ATOM   145  C CB  . ARG A 1 20  ? 43.71000 42.85100 6.28300   1.000 31.94000 ? 64  ARG A CB  1 
ATOM   146  C CG  . ARG A 1 20  ? 44.78600 42.07900 7.02000   1.000 37.56000 ? 64  ARG A CG  1 
ATOM   147  C CD  . ARG A 1 20  ? 44.19400 41.07800 7.99400   1.000 42.88000 ? 64  ARG A CD  1 
ATOM   148  N NE  . ARG A 1 20  ? 44.46500 41.45700 9.37500   1.000 46.67000 ? 64  ARG A NE  1 
ATOM   149  C CZ  . ARG A 1 20  ? 45.61900 41.24700 9.99400   1.000 51.35000 ? 64  ARG A CZ  1 
ATOM   150  N NH1 . ARG A 1 20  ? 46.63600 40.66200 9.38000   1.000 47.98000 ? 64  ARG A NH1 1 
ATOM   151  N NH2 . ARG A 1 20  ? 45.75800 41.63600 11.25800  1.000 53.44000 ? 64  ARG A NH2 1 
ATOM   152  N N   . GLY A 1 21  ? 44.37300 43.70700 3.09300   1.000 29.06000 ? 65  GLY A N   1 
ATOM   153  C CA  . GLY A 1 21  ? 43.86700 43.63700 1.74500   1.000 29.29000 ? 65  GLY A CA  1 
ATOM   154  C C   . GLY A 1 21  ? 43.17100 42.31800 1.48000   1.000 30.49000 ? 65  GLY A C   1 
ATOM   155  O O   . GLY A 1 21  ? 42.91800 41.52800 2.39500   1.000 33.62000 ? 65  GLY A O   1 
ATOM   156  N N   . PRO A 1 22  ? 42.84700 42.05200 0.21200   1.000 32.46000 ? 66  PRO A N   1 
ATOM   157  C CA  . PRO A 1 22  ? 42.12600 40.81600 -0.12300  1.000 31.24000 ? 66  PRO A CA  1 
ATOM   158  C C   . PRO A 1 22  ? 42.99700 39.57100 -0.18300  1.000 29.64000 ? 66  PRO A C   1 
ATOM   159  O O   . PRO A 1 22  ? 42.44800 38.46100 -0.20000  1.000 29.63000 ? 66  PRO A O   1 
ATOM   160  C CB  . PRO A 1 22  ? 41.53400 41.13000 -1.50300  1.000 30.29000 ? 66  PRO A CB  1 
ATOM   161  C CG  . PRO A 1 22  ? 42.50200 42.09300 -2.10100  1.000 30.40000 ? 66  PRO A CG  1 
ATOM   162  C CD  . PRO A 1 22  ? 43.02200 42.92900 -0.96000  1.000 29.12000 ? 66  PRO A CD  1 
ATOM   163  N N   . PHE A 1 23  ? 44.31900 39.70900 -0.21300  1.000 30.69000 ? 67  PHE A N   1 
ATOM   164  C CA  . PHE A 1 23  ? 45.22000 38.57700 -0.39000  1.000 29.63000 ? 67  PHE A CA  1 
ATOM   165  C C   . PHE A 1 23  ? 45.76700 38.11800 0.95400   1.000 31.34000 ? 67  PHE A C   1 
ATOM   166  O O   . PHE A 1 23  ? 46.21800 38.93800 1.76100   1.000 30.52000 ? 67  PHE A O   1 
ATOM   167  C CB  . PHE A 1 23  ? 46.37800 38.94200 -1.32000  1.000 29.17000 ? 67  PHE A CB  1 
ATOM   168  C CG  . PHE A 1 23  ? 45.96500 39.17500 -2.74300  1.000 31.33000 ? 67  PHE A CG  1 
ATOM   169  C CD1 . PHE A 1 23  ? 45.88500 38.11900 -3.63500  1.000 33.58000 ? 67  PHE A CD1 1 
ATOM   170  C CD2 . PHE A 1 23  ? 45.66800 40.45100 -3.19200  1.000 29.69000 ? 67  PHE A CD2 1 
ATOM   171  C CE1 . PHE A 1 23  ? 45.51000 38.33000 -4.94700  1.000 33.57000 ? 67  PHE A CE1 1 
ATOM   172  C CE2 . PHE A 1 23  ? 45.29300 40.66800 -4.50300  1.000 29.12000 ? 67  PHE A CE2 1 
ATOM   173  C CZ  . PHE A 1 23  ? 45.21300 39.60600 -5.38200  1.000 30.60000 ? 67  PHE A CZ  1 
ATOM   174  N N   . SER A 1 24  ? 45.73100 36.80900 1.18700   1.000 30.90000 ? 68  SER A N   1 
ATOM   175  C CA  . SER A 1 24  ? 46.39900 36.24200 2.34900   1.000 29.78000 ? 68  SER A CA  1 
ATOM   176  C C   . SER A 1 24  ? 47.90400 36.22400 2.11700   1.000 31.41000 ? 68  SER A C   1 
ATOM   177  O O   . SER A 1 24  ? 48.37400 35.97900 1.00200   1.000 30.99000 ? 68  SER A O   1 
ATOM   178  C CB  . SER A 1 24  ? 45.88200 34.83200 2.62700   1.000 29.51000 ? 68  SER A CB  1 
ATOM   179  O OG  . SER A 1 24  ? 46.00700 34.01500 1.47800   1.000 34.53000 ? 68  SER A OG  1 
ATOM   180  N N   . VAL A 1 25  ? 48.66400 36.48600 3.17700   1.000 29.00000 ? 69  VAL A N   1 
ATOM   181  C CA  . VAL A 1 25  ? 50.09300 36.74900 3.07300   1.000 25.86000 ? 69  VAL A CA  1 
ATOM   182  C C   . VAL A 1 25  ? 50.87100 35.66100 3.79800   1.000 27.47000 ? 69  VAL A C   1 
ATOM   183  O O   . VAL A 1 25  ? 50.50200 35.24600 4.90200   1.000 30.05000 ? 69  VAL A O   1 
ATOM   184  C CB  . VAL A 1 25  ? 50.44400 38.14100 3.64100   1.000 25.46000 ? 69  VAL A CB  1 
ATOM   185  C CG1 . VAL A 1 25  ? 51.94800 38.37500 3.61700   1.000 23.31000 ? 69  VAL A CG1 1 
ATOM   186  C CG2 . VAL A 1 25  ? 49.72700 39.22000 2.85800   1.000 25.89000 ? 69  VAL A CG2 1 
ATOM   187  N N   . ALA A 1 26  ? 51.94600 35.19800 3.16600   1.000 25.99000 ? 70  ALA A N   1 
ATOM   188  C CA  . ALA A 1 26  ? 52.94000 34.34500 3.79500   1.000 23.31000 ? 70  ALA A CA  1 
ATOM   189  C C   . ALA A 1 26  ? 54.27300 35.08100 3.81200   1.000 23.15000 ? 70  ALA A C   1 
ATOM   190  O O   . ALA A 1 26  ? 54.50500 36.00000 3.02200   1.000 24.28000 ? 70  ALA A O   1 
ATOM   191  C CB  . ALA A 1 26  ? 53.07400 33.00200 3.06500   1.000 27.15000 ? 70  ALA A CB  1 
ATOM   192  N N   . THR A 1 27  ? 55.14700 34.68400 4.73500   1.000 24.81000 ? 71  THR A N   1 
ATOM   193  C CA  . THR A 1 27  ? 56.41400 35.37000 4.93500   1.000 22.91000 ? 71  THR A CA  1 
ATOM   194  C C   . THR A 1 27  ? 57.56600 34.37900 4.85300   1.000 23.63000 ? 71  THR A C   1 
ATOM   195  O O   . THR A 1 27  ? 57.39400 33.17200 5.03400   1.000 27.40000 ? 71  THR A O   1 
ATOM   196  C CB  . THR A 1 27  ? 56.46400 36.10700 6.28600   1.000 26.16000 ? 71  THR A CB  1 
ATOM   197  O OG1 . THR A 1 27  ? 56.47200 35.15600 7.35800   1.000 26.40000 ? 71  THR A OG1 1 
ATOM   198  C CG2 . THR A 1 27  ? 55.26300 37.02800 6.44200   1.000 24.43000 ? 71  THR A CG2 1 
ATOM   199  N N   . GLU A 1 28  ? 58.75200 34.91200 4.57500   1.000 26.15000 ? 72  GLU A N   1 
ATOM   200  C CA  . GLU A 1 28  ? 59.96800 34.11600 4.53000   1.000 26.11000 ? 72  GLU A CA  1 
ATOM   201  C C   . GLU A 1 28  ? 61.12700 34.97500 5.01300   1.000 24.09000 ? 72  GLU A C   1 
ATOM   202  O O   . GLU A 1 28  ? 61.18900 36.16900 4.71100   1.000 26.05000 ? 72  GLU A O   1 
ATOM   203  C CB  . GLU A 1 28  ? 60.24500 33.58500 3.11800   1.000 29.86000 ? 72  GLU A CB  1 
ATOM   204  C CG  . GLU A 1 28  ? 61.55400 32.82400 2.99500   1.000 33.26000 ? 72  GLU A CG  1 
ATOM   205  C CD  . GLU A 1 28  ? 61.75700 32.21200 1.62400   1.000 37.23000 ? 72  GLU A CD  1 
ATOM   206  O OE1 . GLU A 1 28  ? 61.01000 32.56900 0.69000   1.000 35.20000 ? 72  GLU A OE1 1 
ATOM   207  O OE2 . GLU A 1 28  ? 62.66600 31.36600 1.48400   1.000 39.89000 ? 72  GLU A OE2 1 
ATOM   208  N N   . ARG A 1 29  ? 62.03200 34.36500 5.77400   1.000 24.70000 ? 73  ARG A N   1 
ATOM   209  C CA  . ARG A 1 29  ? 63.21400 35.05800 6.26800   1.000 25.02000 ? 73  ARG A CA  1 
ATOM   210  C C   . ARG A 1 29  ? 64.38100 34.82100 5.32100   1.000 23.45000 ? 73  ARG A C   1 
ATOM   211  O O   . ARG A 1 29  ? 64.64400 33.68200 4.92100   1.000 25.62000 ? 73  ARG A O   1 
ATOM   212  C CB  . ARG A 1 29  ? 63.58200 34.58700 7.67600   1.000 29.14000 ? 73  ARG A CB  1 
ATOM   213  C CG  . ARG A 1 29  ? 62.54700 34.89000 8.74100   1.000 31.27000 ? 73  ARG A CG  1 
ATOM   214  C CD  . ARG A 1 29  ? 63.11800 34.62600 10.12600  1.000 39.55000 ? 73  ARG A CD  1 
ATOM   215  N NE  . ARG A 1 29  ? 62.10800 34.74800 11.17100  1.000 45.70000 ? 73  ARG A NE  1 
ATOM   216  C CZ  . ARG A 1 29  ? 61.77300 35.88800 11.75900  1.000 48.82000 ? 73  ARG A CZ  1 
ATOM   217  N NH1 . ARG A 1 29  ? 62.34600 37.03300 11.42600  1.000 46.50000 ? 73  ARG A NH1 1 
ATOM   218  N NH2 . ARG A 1 29  ? 60.83700 35.87900 12.70500  1.000 51.63000 ? 73  ARG A NH2 1 
ATOM   219  N N   . VAL A 1 30  ? 65.07500 35.89900 4.96900   1.000 22.37000 ? 74  VAL A N   1 
ATOM   220  C CA  . VAL A 1 30  ? 66.27100 35.84400 4.13800   1.000 20.97000 ? 74  VAL A CA  1 
ATOM   221  C C   . VAL A 1 30  ? 67.47200 36.16100 5.01600   1.000 19.94000 ? 74  VAL A C   1 
ATOM   222  O O   . VAL A 1 30  ? 67.48000 37.17500 5.72500   1.000 24.25000 ? 74  VAL A O   1 
ATOM   223  C CB  . VAL A 1 30  ? 66.18100 36.81900 2.95200   1.000 21.03000 ? 74  VAL A CB  1 
ATOM   224  C CG1 . VAL A 1 30  ? 67.52300 36.92000 2.24200   1.000 21.97000 ? 74  VAL A CG1 1 
ATOM   225  C CG2 . VAL A 1 30  ? 65.09800 36.36800 1.99500   1.000 21.61000 ? 74  VAL A CG2 1 
ATOM   226  N N   . SER A 1 31  ? 68.48300 35.29900 4.96300   1.000 21.68000 ? 75  SER A N   1 
ATOM   227  C CA  . SER A 1 31  ? 69.63400 35.42900 5.84500   1.000 21.38000 ? 75  SER A CA  1 
ATOM   228  C C   . SER A 1 31  ? 70.39000 36.72500 5.58200   1.000 24.31000 ? 75  SER A C   1 
ATOM   229  O O   . SER A 1 31  ? 70.49200 37.19000 4.44300   1.000 23.23000 ? 75  SER A O   1 
ATOM   230  C CB  . SER A 1 31  ? 70.56300 34.23000 5.66500   1.000 21.77000 ? 75  SER A CB  1 
ATOM   231  O OG  . SER A 1 31  ? 71.87100 34.52500 6.11800   1.000 22.93000 ? 75  SER A OG  1 
ATOM   232  N N   . SER A 1 32  ? 70.93000 37.30900 6.65300   1.000 22.40000 ? 76  SER A N   1 
ATOM   233  C CA  . SER A 1 32  ? 71.69600 38.54200 6.53200   1.000 20.81000 ? 76  SER A CA  1 
ATOM   234  C C   . SER A 1 32  ? 73.01600 38.34700 5.80200   1.000 20.21000 ? 76  SER A C   1 
ATOM   235  O O   . SER A 1 32  ? 73.67000 39.34100 5.47000   1.000 21.86000 ? 76  SER A O   1 
ATOM   236  C CB  . SER A 1 32  ? 71.97200 39.12900 7.91500   1.000 22.36000 ? 76  SER A CB  1 
ATOM   237  O OG  . SER A 1 32  ? 72.72000 38.21600 8.69500   1.000 20.04000 ? 76  SER A OG  1 
ATOM   238  N N   . PHE A 1 33  ? 73.43000 37.10700 5.56600   1.000 20.45000 ? 77  PHE A N   1 
ATOM   239  C CA  . PHE A 1 33  ? 74.64300 36.82800 4.81700   1.000 20.57000 ? 77  PHE A CA  1 
ATOM   240  C C   . PHE A 1 33  ? 74.39900 36.79400 3.31800   1.000 22.15000 ? 77  PHE A C   1 
ATOM   241  O O   . PHE A 1 33  ? 75.28300 36.37100 2.56500   1.000 23.33000 ? 77  PHE A O   1 
ATOM   242  C CB  . PHE A 1 33  ? 75.25900 35.51000 5.28600   1.000 21.21000 ? 77  PHE A CB  1 
ATOM   243  C CG  . PHE A 1 33  ? 75.66300 35.51700 6.73300   1.000 22.93000 ? 77  PHE A CG  1 
ATOM   244  C CD1 . PHE A 1 33  ? 76.70400 36.32000 7.17000   1.000 24.16000 ? 77  PHE A CD1 1 
ATOM   245  C CD2 . PHE A 1 33  ? 75.00500 34.72000 7.65500   1.000 24.90000 ? 77  PHE A CD2 1 
ATOM   246  C CE1 . PHE A 1 33  ? 77.08000 36.33000 8.49900   1.000 23.93000 ? 77  PHE A CE1 1 
ATOM   247  C CE2 . PHE A 1 33  ? 75.37700 34.72400 8.98600   1.000 26.32000 ? 77  PHE A CE2 1 
ATOM   248  C CZ  . PHE A 1 33  ? 76.41600 35.53000 9.40800   1.000 23.43000 ? 77  PHE A CZ  1 
ATOM   249  N N   . ALA A 1 34  ? 73.21900 37.22200 2.87400   1.000 23.58000 ? 78  ALA A N   1 
ATOM   250  C CA  . ALA A 1 34  ? 72.95500 37.34500 1.45100   1.000 24.08000 ? 78  ALA A CA  1 
ATOM   251  C C   . ALA A 1 34  ? 73.91600 38.34800 0.82800   1.000 24.51000 ? 78  ALA A C   1 
ATOM   252  O O   . ALA A 1 34  ? 74.41100 39.26500 1.48900   1.000 24.83000 ? 78  ALA A O   1 
ATOM   253  C CB  . ALA A 1 34  ? 71.50900 37.77700 1.20900   1.000 22.92000 ? 78  ALA A CB  1 
ATOM   254  N N   . SER A 1 35  ? 74.18300 38.16200 -0.45800  1.000 25.11000 ? 79  SER A N   1 
ATOM   255  C CA  . SER A 1 35  ? 75.16900 38.98000 -1.14500  1.000 20.35000 ? 79  SER A CA  1 
ATOM   256  C C   . SER A 1 35  ? 74.58300 40.34700 -1.47300  1.000 21.52000 ? 79  SER A C   1 
ATOM   257  O O   . SER A 1 35  ? 73.50600 40.44500 -2.06800  1.000 23.96000 ? 79  SER A O   1 
ATOM   258  C CB  . SER A 1 35  ? 75.64100 38.27900 -2.41600  1.000 23.30000 ? 79  SER A CB  1 
ATOM   259  O OG  . SER A 1 35  ? 76.74000 38.96200 -2.98800  1.000 31.82000 ? 79  SER A OG  1 
ATOM   260  N N   . GLY A 1 36  ? 75.28900 41.40100 -1.06700  1.000 20.34000 ? 80  GLY A N   1 
ATOM   261  C CA  . GLY A 1 36  ? 74.92400 42.75200 -1.42500  1.000 22.73000 ? 80  GLY A CA  1 
ATOM   262  C C   . GLY A 1 36  ? 74.06700 43.49300 -0.42200  1.000 20.79000 ? 80  GLY A C   1 
ATOM   263  O O   . GLY A 1 36  ? 73.94200 44.71800 -0.53100  1.000 22.22000 ? 80  GLY A O   1 
ATOM   264  N N   . PHE A 1 37  ? 73.46900 42.80100 0.54400   1.000 23.08000 ? 81  PHE A N   1 
ATOM   265  C CA  . PHE A 1 37  ? 72.64000 43.45800 1.54600   1.000 20.67000 ? 81  PHE A CA  1 
ATOM   266  C C   . PHE A 1 37  ? 72.55700 42.56000 2.77200   1.000 20.42000 ? 81  PHE A C   1 
ATOM   267  O O   . PHE A 1 37  ? 73.01100 41.41400 2.75900   1.000 21.41000 ? 81  PHE A O   1 
ATOM   268  C CB  . PHE A 1 37  ? 71.24800 43.79100 0.99600   1.000 21.04000 ? 81  PHE A CB  1 
ATOM   269  C CG  . PHE A 1 37  ? 70.36500 42.59200 0.78600   1.000 20.26000 ? 81  PHE A CG  1 
ATOM   270  C CD1 . PHE A 1 37  ? 70.69100 41.62400 -0.15000  1.000 21.71000 ? 81  PHE A CD1 1 
ATOM   271  C CD2 . PHE A 1 37  ? 69.19400 42.44700 1.51000   1.000 20.88000 ? 81  PHE A CD2 1 
ATOM   272  C CE1 . PHE A 1 37  ? 69.87400 40.52700 -0.34600  1.000 20.87000 ? 81  PHE A CE1 1 
ATOM   273  C CE2 . PHE A 1 37  ? 68.37300 41.35300 1.31600   1.000 22.06000 ? 81  PHE A CE2 1 
ATOM   274  C CZ  . PHE A 1 37  ? 68.71400 40.39100 0.38700   1.000 22.28000 ? 81  PHE A CZ  1 
ATOM   275  N N   . GLY A 1 38  ? 71.96800 43.09800 3.83600   1.000 21.92000 ? 82  GLY A N   1 
ATOM   276  C CA  . GLY A 1 38  ? 71.92000 42.39100 5.10100   1.000 20.81000 ? 82  GLY A CA  1 
ATOM   277  C C   . GLY A 1 38  ? 70.65200 41.60000 5.35200   1.000 23.58000 ? 82  GLY A C   1 
ATOM   278  O O   . GLY A 1 38  ? 70.11700 41.62000 6.46400   1.000 25.25000 ? 82  GLY A O   1 
ATOM   279  N N   . GLY A 1 39  ? 70.16900 40.88900 4.33900   1.000 22.74000 ? 83  GLY A N   1 
ATOM   280  C CA  . GLY A 1 39  ? 69.00400 40.05400 4.51800   1.000 19.26000 ? 83  GLY A CA  1 
ATOM   281  C C   . GLY A 1 39  ? 67.73200 40.85700 4.71900   1.000 18.06000 ? 83  GLY A C   1 
ATOM   282  O O   . GLY A 1 39  ? 67.69000 42.07900 4.58400   1.000 22.50000 ? 83  GLY A O   1 
ATOM   283  N N   . GLY A 1 40  ? 66.67500 40.12600 5.04500   1.000 18.21000 ? 84  GLY A N   1 
ATOM   284  C CA  . GLY A 1 40  ? 65.39800 40.74500 5.33000   1.000 17.33000 ? 84  GLY A CA  1 
ATOM   285  C C   . GLY A 1 40  ? 64.29700 39.70200 5.36400   1.000 19.03000 ? 84  GLY A C   1 
ATOM   286  O O   . GLY A 1 40  ? 64.55500 38.51100 5.53100   1.000 21.26000 ? 84  GLY A O   1 
ATOM   287  N N   . THR A 1 41  ? 63.06900 40.18800 5.19600   1.000 20.28000 ? 85  THR A N   1 
ATOM   288  C CA  . THR A 1 41  ? 61.87000 39.36200 5.23600   1.000 21.71000 ? 85  THR A CA  1 
ATOM   289  C C   . THR A 1 41  ? 61.04000 39.63300 3.99200   1.000 21.26000 ? 85  THR A C   1 
ATOM   290  O O   . THR A 1 41  ? 60.78700 40.79300 3.65600   1.000 20.06000 ? 85  THR A O   1 
ATOM   291  C CB  . THR A 1 41  ? 61.03800 39.65000 6.48700   1.000 20.93000 ? 85  THR A CB  1 
ATOM   292  O OG1 . THR A 1 41  ? 61.83000 39.42200 7.65900   1.000 21.85000 ? 85  THR A OG1 1 
ATOM   293  C CG2 . THR A 1 41  ? 59.80700 38.76000 6.52400   1.000 22.10000 ? 85  THR A CG2 1 
ATOM   294  N N   . ILE A 1 42  ? 60.61200 38.56700 3.32400   1.000 23.07000 ? 86  ILE A N   1 
ATOM   295  C CA  . ILE A 1 42  ? 59.82300 38.66000 2.10200   1.000 21.74000 ? 86  ILE A CA  1 
ATOM   296  C C   . ILE A 1 42  ? 58.36600 38.38400 2.44100   1.000 21.36000 ? 86  ILE A C   1 
ATOM   297  O O   . ILE A 1 42  ? 58.02900 37.30100 2.93400   1.000 23.95000 ? 86  ILE A O   1 
ATOM   298  C CB  . ILE A 1 42  ? 60.32300 37.67700 1.03200   1.000 23.60000 ? 86  ILE A CB  1 
ATOM   299  C CG1 . ILE A 1 42  ? 61.80400 37.90600 0.73400   1.000 23.60000 ? 86  ILE A CG1 1 
ATOM   300  C CG2 . ILE A 1 42  ? 59.48400 37.79900 -0.23100  1.000 24.16000 ? 86  ILE A CG2 1 
ATOM   301  C CD1 . ILE A 1 42  ? 62.37600 36.90800 -0.24800  1.000 23.66000 ? 86  ILE A CD1 1 
ATOM   302  N N   . TYR A 1 43  ? 57.50000 39.35600 2.16800   1.000 22.99000 ? 87  TYR A N   1 
ATOM   303  C CA  . TYR A 1 43  ? 56.05900 39.20000 2.31100   1.000 23.20000 ? 87  TYR A CA  1 
ATOM   304  C C   . TYR A 1 43  ? 55.45900 38.99700 0.92600   1.000 23.74000 ? 87  TYR A C   1 
ATOM   305  O O   . TYR A 1 43  ? 55.54100 39.89100 0.07800   1.000 23.89000 ? 87  TYR A O   1 
ATOM   306  C CB  . TYR A 1 43  ? 55.43600 40.42600 2.98100   1.000 24.07000 ? 87  TYR A CB  1 
ATOM   307  C CG  . TYR A 1 43  ? 55.95200 40.72500 4.37100   1.000 23.52000 ? 87  TYR A CG  1 
ATOM   308  C CD1 . TYR A 1 43  ? 57.17700 41.35300 4.56100   1.000 23.00000 ? 87  TYR A CD1 1 
ATOM   309  C CD2 . TYR A 1 43  ? 55.20100 40.40100 5.49200   1.000 24.12000 ? 87  TYR A CD2 1 
ATOM   310  C CE1 . TYR A 1 43  ? 57.64500 41.63500 5.83100   1.000 23.61000 ? 87  TYR A CE1 1 
ATOM   311  C CE2 . TYR A 1 43  ? 55.66100 40.67900 6.76400   1.000 23.86000 ? 87  TYR A CE2 1 
ATOM   312  C CZ  . TYR A 1 43  ? 56.88200 41.29500 6.92800   1.000 23.86000 ? 87  TYR A CZ  1 
ATOM   313  O OH  . TYR A 1 43  ? 57.33700 41.57200 8.19600   1.000 23.60000 ? 87  TYR A OH  1 
ATOM   314  N N   . TYR A 1 44  ? 54.85800 37.83400 0.69700   1.000 24.70000 ? 88  TYR A N   1 
ATOM   315  C CA  . TYR A 1 44  ? 54.30200 37.53800 -0.61300  1.000 26.35000 ? 88  TYR A CA  1 
ATOM   316  C C   . TYR A 1 44  ? 52.88100 37.01000 -0.48600  1.000 27.01000 ? 88  TYR A C   1 
ATOM   317  O O   . TYR A 1 44  ? 52.53900 36.36000 0.50700   1.000 28.53000 ? 88  TYR A O   1 
ATOM   318  C CB  . TYR A 1 44  ? 55.16900 36.51800 -1.36900  1.000 23.84000 ? 88  TYR A CB  1 
ATOM   319  C CG  . TYR A 1 44  ? 55.28600 35.16400 -0.70500  1.000 25.87000 ? 88  TYR A CG  1 
ATOM   320  C CD1 . TYR A 1 44  ? 54.38400 34.15000 -0.99300  1.000 25.89000 ? 88  TYR A CD1 1 
ATOM   321  C CD2 . TYR A 1 44  ? 56.30900 34.89500 0.19600   1.000 23.75000 ? 88  TYR A CD2 1 
ATOM   322  C CE1 . TYR A 1 44  ? 54.48700 32.91100 -0.39700  1.000 26.22000 ? 88  TYR A CE1 1 
ATOM   323  C CE2 . TYR A 1 44  ? 56.42200 33.65400 0.79700   1.000 24.04000 ? 88  TYR A CE2 1 
ATOM   324  C CZ  . TYR A 1 44  ? 55.50700 32.66700 0.49600   1.000 25.91000 ? 88  TYR A CZ  1 
ATOM   325  O OH  . TYR A 1 44  ? 55.60700 31.42900 1.08700   1.000 28.92000 ? 88  TYR A OH  1 
ATOM   326  N N   . PRO A 1 45  ? 52.03100 37.28500 -1.47500  1.000 26.94000 ? 89  PRO A N   1 
ATOM   327  C CA  . PRO A 1 45  ? 50.65500 36.77500 -1.42600  1.000 28.61000 ? 89  PRO A CA  1 
ATOM   328  C C   . PRO A 1 45  ? 50.61100 35.27500 -1.67300  1.000 29.76000 ? 89  PRO A C   1 
ATOM   329  O O   . PRO A 1 45  ? 51.36700 34.73700 -2.48400  1.000 28.22000 ? 89  PRO A O   1 
ATOM   330  C CB  . PRO A 1 45  ? 49.94800 37.54700 -2.54900  1.000 27.64000 ? 89  PRO A CB  1 
ATOM   331  C CG  . PRO A 1 45  ? 50.85400 38.70700 -2.86500  1.000 24.99000 ? 89  PRO A CG  1 
ATOM   332  C CD  . PRO A 1 45  ? 52.23500 38.20600 -2.60300  1.000 25.56000 ? 89  PRO A CD  1 
ATOM   333  N N   . ARG A 1 46  ? 49.70600 34.59900 -0.96000  1.000 30.30000 ? 90  ARG A N   1 
ATOM   334  C CA  . ARG A 1 46  ? 49.58100 33.15300 -1.10900  1.000 31.98000 ? 90  ARG A CA  1 
ATOM   335  C C   . ARG A 1 46  ? 48.90800 32.78400 -2.42600  1.000 32.64000 ? 90  ARG A C   1 
ATOM   336  O O   . ARG A 1 46  ? 49.34400 31.85200 -3.11200  1.000 35.46000 ? 90  ARG A O   1 
ATOM   337  C CB  . ARG A 1 46  ? 48.79800 32.56900 0.06700   1.000 33.89000 ? 90  ARG A CB  1 
ATOM   338  C CG  . ARG A 1 46  ? 49.56200 32.51700 1.38000   1.000 34.63000 ? 90  ARG A CG  1 
ATOM   339  C CD  . ARG A 1 46  ? 48.62400 32.20100 2.53600   1.000 34.77000 ? 90  ARG A CD  1 
ATOM   340  N NE  . ARG A 1 46  ? 47.67800 31.14400 2.19500   1.000 43.05000 ? 90  ARG A NE  1 
ATOM   341  C CZ  . ARG A 1 46  ? 46.72600 30.69800 3.00300   1.000 47.02000 ? 90  ARG A CZ  1 
ATOM   342  N NH1 . ARG A 1 46  ? 46.56600 31.19100 4.22100   1.000 45.46000 ? 90  ARG A NH1 1 
ATOM   343  N NH2 . ARG A 1 46  ? 45.91400 29.73300 2.58000   1.000 49.38000 ? 90  ARG A NH2 1 
ATOM   344  N N   . GLU A 1 47  ? 47.84800 33.49900 -2.79100  1.000 34.06000 ? 91  GLU A N   1 
ATOM   345  C CA  . GLU A 1 47  ? 47.07000 33.15400 -3.97300  1.000 36.32000 ? 91  GLU A CA  1 
ATOM   346  C C   . GLU A 1 47  ? 47.88800 33.35300 -5.24300  1.000 33.02000 ? 91  GLU A C   1 
ATOM   347  O O   . GLU A 1 47  ? 48.68100 34.29200 -5.35300  1.000 32.19000 ? 91  GLU A O   1 
ATOM   348  C CB  . GLU A 1 47  ? 45.79400 33.99400 -4.02700  1.000 34.66000 ? 91  GLU A CB  1 
ATOM   349  C CG  . GLU A 1 47  ? 44.79400 33.70300 -2.90900  1.000 38.09000 ? 91  GLU A CG  1 
ATOM   350  C CD  . GLU A 1 47  ? 45.13400 34.39200 -1.59400  1.000 37.53000 ? 91  GLU A CD  1 
ATOM   351  O OE1 . GLU A 1 47  ? 46.27600 34.87400 -1.43500  1.000 34.44000 ? 91  GLU A OE1 1 
ATOM   352  O OE2 . GLU A 1 47  ? 44.24800 34.45300 -0.71500  1.000 39.28000 ? 91  GLU A OE2 1 
ATOM   353  N N   . THR A 1 48  ? 47.69000 32.45500 -6.21200  1.000 34.52000 ? 92  THR A N   1 
ATOM   354  C CA  . THR A 1 48  ? 48.47600 32.45500 -7.43800  1.000 33.51000 ? 92  THR A CA  1 
ATOM   355  C C   . THR A 1 48  ? 47.65200 32.41400 -8.71800  1.000 34.76000 ? 92  THR A C   1 
ATOM   356  O O   . THR A 1 48  ? 48.23200 32.56100 -9.80000  1.000 33.18000 ? 92  THR A O   1 
ATOM   357  C CB  . THR A 1 48  ? 49.44600 31.26200 -7.45400  1.000 34.61000 ? 92  THR A CB  1 
ATOM   358  O OG1 . THR A 1 48  ? 48.70500 30.03900 -7.35300  1.000 34.98000 ? 92  THR A OG1 1 
ATOM   359  C CG2 . THR A 1 48  ? 50.42800 31.34900 -6.29700  1.000 34.93000 ? 92  THR A CG2 1 
ATOM   360  N N   . ASP A 1 49  ? 46.33400 32.22800 -8.64000  1.000 36.53000 ? 93  ASP A N   1 
ATOM   361  C CA  . ASP A 1 49  ? 45.51400 32.02000 -9.82800  1.000 34.95000 ? 93  ASP A CA  1 
ATOM   362  C C   . ASP A 1 49  ? 45.21000 33.30400 -10.59100 1.000 36.26000 ? 93  ASP A C   1 
ATOM   363  O O   . ASP A 1 49  ? 44.58000 33.23600 -11.65100 1.000 38.66000 ? 93  ASP A O   1 
ATOM   364  C CB  . ASP A 1 49  ? 44.20500 31.32000 -9.44800  1.000 36.24000 ? 93  ASP A CB  1 
ATOM   365  C CG  . ASP A 1 49  ? 43.48300 32.00200 -8.29700  1.000 37.69000 ? 93  ASP A CG  1 
ATOM   366  O OD1 . ASP A 1 49  ? 43.77600 33.18200 -8.01100  1.000 37.28000 ? 93  ASP A OD1 1 
ATOM   367  O OD2 . ASP A 1 49  ? 42.62300 31.34800 -7.67000  1.000 38.01000 ? 93  ASP A OD2 1 
ATOM   368  N N   . GLU A 1 50  ? 45.63100 34.46400 -10.08900 1.000 34.32000 ? 94  GLU A N   1 
ATOM   369  C CA  . GLU A 1 50  ? 45.43500 35.71900 -10.79900 1.000 30.75000 ? 94  GLU A CA  1 
ATOM   370  C C   . GLU A 1 50  ? 46.67200 36.17300 -11.56100 1.000 31.04000 ? 94  GLU A C   1 
ATOM   371  O O   . GLU A 1 50  ? 46.57400 37.10300 -12.36800 1.000 32.87000 ? 94  GLU A O   1 
ATOM   372  C CB  . GLU A 1 50  ? 45.00300 36.82400 -9.82600  1.000 33.82000 ? 94  GLU A CB  1 
ATOM   373  C CG  . GLU A 1 50  ? 43.65500 36.58300 -9.16600  1.000 30.90000 ? 94  GLU A CG  1 
ATOM   374  C CD  . GLU A 1 50  ? 43.12700 37.81400 -8.45700  1.000 30.77000 ? 94  GLU A CD  1 
ATOM   375  O OE1 . GLU A 1 50  ? 43.63900 38.92100 -8.72500  1.000 30.41000 ? 94  GLU A OE1 1 
ATOM   376  O OE2 . GLU A 1 50  ? 42.20100 37.67700 -7.63000  1.000 36.37000 ? 94  GLU A OE2 1 
ATOM   377  N N   . GLY A 1 51  ? 47.81800 35.54800 -11.33300 1.000 30.99000 ? 95  GLY A N   1 
ATOM   378  C CA  . GLY A 1 51  ? 49.04900 35.89800 -12.01100 1.000 29.85000 ? 95  GLY A CA  1 
ATOM   379  C C   . GLY A 1 51  ? 50.14700 36.29000 -11.03800 1.000 28.83000 ? 95  GLY A C   1 
ATOM   380  O O   . GLY A 1 51  ? 49.93900 36.43700 -9.83500  1.000 29.95000 ? 95  GLY A O   1 
ATOM   381  N N   . THR A 1 52  ? 51.34100 36.45400 -11.60300 1.000 27.40000 ? 96  THR A N   1 
ATOM   382  C CA  . THR A 1 52  ? 52.49500 36.86000 -10.81500 1.000 25.65000 ? 96  THR A CA  1 
ATOM   383  C C   . THR A 1 52  ? 52.40300 38.33900 -10.45800 1.000 28.62000 ? 96  THR A C   1 
ATOM   384  O O   . THR A 1 52  ? 51.78200 39.13800 -11.16500 1.000 32.53000 ? 96  THR A O   1 
ATOM   385  C CB  . THR A 1 52  ? 53.79400 36.58500 -11.57600 1.000 27.89000 ? 96  THR A CB  1 
ATOM   386  O OG1 . THR A 1 52  ? 53.79400 37.30800 -12.81300 1.000 31.85000 ? 96  THR A OG1 1 
ATOM   387  C CG2 . THR A 1 52  ? 53.93500 35.09900 -11.86300 1.000 27.85000 ? 96  THR A CG2 1 
ATOM   388  N N   . PHE A 1 53  ? 53.03300 38.70000 -9.34600  1.000 29.38000 ? 97  PHE A N   1 
ATOM   389  C CA  . PHE A 1 53  ? 52.94500 40.03900 -8.78800  1.000 25.41000 ? 97  PHE A CA  1 
ATOM   390  C C   . PHE A 1 53  ? 54.25600 40.79100 -8.97500  1.000 24.55000 ? 97  PHE A C   1 
ATOM   391  O O   . PHE A 1 53  ? 55.30900 40.20400 -9.23600  1.000 25.77000 ? 97  PHE A O   1 
ATOM   392  C CB  . PHE A 1 53  ? 52.59600 39.98700 -7.29500  1.000 26.08000 ? 97  PHE A CB  1 
ATOM   393  C CG  . PHE A 1 53  ? 51.35200 39.20300 -6.98600  1.000 25.35000 ? 97  PHE A CG  1 
ATOM   394  C CD1 . PHE A 1 53  ? 50.11500 39.82400 -6.95900  1.000 24.62000 ? 97  PHE A CD1 1 
ATOM   395  C CD2 . PHE A 1 53  ? 51.42200 37.84600 -6.71500  1.000 25.54000 ? 97  PHE A CD2 1 
ATOM   396  C CE1 . PHE A 1 53  ? 48.97100 39.10700 -6.67300  1.000 23.78000 ? 97  PHE A CE1 1 
ATOM   397  C CE2 . PHE A 1 53  ? 50.28100 37.12400 -6.42900  1.000 25.12000 ? 97  PHE A CE2 1 
ATOM   398  C CZ  . PHE A 1 53  ? 49.05400 37.75500 -6.40800  1.000 25.49000 ? 97  PHE A CZ  1 
ATOM   399  N N   . GLY A 1 54  ? 54.17100 42.11500 -8.84100  1.000 24.85000 ? 98  GLY A N   1 
ATOM   400  C CA  . GLY A 1 54  ? 55.35900 42.93200 -8.73900  1.000 24.78000 ? 98  GLY A CA  1 
ATOM   401  C C   . GLY A 1 54  ? 55.88200 42.97400 -7.31500  1.000 24.33000 ? 98  GLY A C   1 
ATOM   402  O O   . GLY A 1 54  ? 55.21400 42.56100 -6.36700  1.000 24.35000 ? 98  GLY A O   1 
ATOM   403  N N   . ALA A 1 55  ? 57.10100 43.48800 -7.16800  1.000 24.81000 ? 99  ALA A N   1 
ATOM   404  C CA  . ALA A 1 55  ? 57.78600 43.49600 -5.88500  1.000 23.25000 ? 99  ALA A CA  1 
ATOM   405  C C   . ALA A 1 55  ? 58.34500 44.87700 -5.57900  1.000 23.63000 ? 99  ALA A C   1 
ATOM   406  O O   . ALA A 1 55  ? 58.71700 45.63200 -6.48100  1.000 22.67000 ? 99  ALA A O   1 
ATOM   407  C CB  . ALA A 1 55  ? 58.92400 42.47100 -5.84800  1.000 21.15000 ? 99  ALA A CB  1 
ATOM   408  N N   . VAL A 1 56  ? 58.41100 45.19300 -4.28600  1.000 23.27000 ? 100 VAL A N   1 
ATOM   409  C CA  . VAL A 1 56  ? 59.01000 46.42800 -3.79600  1.000 22.85000 ? 100 VAL A CA  1 
ATOM   410  C C   . VAL A 1 56  ? 59.92600 46.08200 -2.62700  1.000 21.74000 ? 100 VAL A C   1 
ATOM   411  O O   . VAL A 1 56  ? 59.54000 45.32100 -1.73200  1.000 20.83000 ? 100 VAL A O   1 
ATOM   412  C CB  . VAL A 1 56  ? 57.94000 47.46400 -3.38500  1.000 21.19000 ? 100 VAL A CB  1 
ATOM   413  C CG1 . VAL A 1 56  ? 56.94800 46.87100 -2.39100  1.000 24.62000 ? 100 VAL A CG1 1 
ATOM   414  C CG2 . VAL A 1 56  ? 58.59100 48.72300 -2.82700  1.000 20.72000 ? 100 VAL A CG2 1 
ATOM   415  N N   . ALA A 1 57  ? 61.14900 46.60400 -2.66000  1.000 20.91000 ? 101 ALA A N   1 
ATOM   416  C CA  . ALA A 1 57  ? 62.10400 46.45300 -1.57100  1.000 19.53000 ? 101 ALA A CA  1 
ATOM   417  C C   . ALA A 1 57  ? 62.05500 47.69900 -0.69900  1.000 18.87000 ? 101 ALA A C   1 
ATOM   418  O O   . ALA A 1 57  ? 62.08400 48.82200 -1.21300  1.000 18.88000 ? 101 ALA A O   1 
ATOM   419  C CB  . ALA A 1 57  ? 63.52000 46.23100 -2.10400  1.000 17.76000 ? 101 ALA A CB  1 
ATOM   420  N N   . VAL A 1 58  ? 61.98000 47.50200 0.61300   1.000 20.28000 ? 102 VAL A N   1 
ATOM   421  C CA  . VAL A 1 58  ? 61.79900 48.59700 1.56000   1.000 18.02000 ? 102 VAL A CA  1 
ATOM   422  C C   . VAL A 1 58  ? 63.04800 48.69600 2.42800   1.000 18.14000 ? 102 VAL A C   1 
ATOM   423  O O   . VAL A 1 58  ? 63.43100 47.72000 3.08600   1.000 19.68000 ? 102 VAL A O   1 
ATOM   424  C CB  . VAL A 1 58  ? 60.53900 48.40400 2.41800   1.000 17.80000 ? 102 VAL A CB  1 
ATOM   425  C CG1 . VAL A 1 58  ? 60.20700 49.68300 3.15200   1.000 19.22000 ? 102 VAL A CG1 1 
ATOM   426  C CG2 . VAL A 1 58  ? 59.36900 47.96900 1.54700   1.000 17.68000 ? 102 VAL A CG2 1 
ATOM   427  N N   . ALA A 1 59  ? 63.68600 49.88300 2.43000   1.000 16.79000 ? 103 ALA A N   1 
ATOM   428  C CA  . ALA A 1 59  ? 64.91400 50.10800 3.17800   1.000 19.33000 ? 103 ALA A CA  1 
ATOM   429  C C   . ALA A 1 59  ? 64.65400 50.93700 4.42900   1.000 19.30000 ? 103 ALA A C   1 
ATOM   430  O O   . ALA A 1 59  ? 63.82000 51.84900 4.41200   1.000 17.48000 ? 103 ALA A O   1 
ATOM   431  C CB  . ALA A 1 59  ? 65.96800 50.82100 2.32100   1.000 18.41000 ? 103 ALA A CB  1 
ATOM   432  N N   . PRO A 1 60  ? 65.35800 50.65300 5.52400   1.000 19.03000 ? 104 PRO A N   1 
ATOM   433  C CA  . PRO A 1 60  ? 65.19000 51.46200 6.73400   1.000 20.38000 ? 104 PRO A CA  1 
ATOM   434  C C   . PRO A 1 60  ? 66.10800 52.67200 6.74800   1.000 20.87000 ? 104 PRO A C   1 
ATOM   435  O O   . PRO A 1 60  ? 66.92500 52.86900 5.84100   1.000 22.45000 ? 104 PRO A O   1 
ATOM   436  C CB  . PRO A 1 60  ? 65.54200 50.47900 7.85200   1.000 19.94000 ? 104 PRO A CB  1 
ATOM   437  C CG  . PRO A 1 60  ? 66.58200 49.60800 7.23100   1.000 20.15000 ? 104 PRO A CG  1 
ATOM   438  C CD  . PRO A 1 60  ? 66.24400 49.50000 5.75700   1.000 19.22000 ? 104 PRO A CD  1 
ATOM   439  N N   . GLY A 1 61  ? 65.97900 53.48600 7.79100   1.000 20.41000 ? 105 GLY A N   1 
ATOM   440  C CA  . GLY A 1 61  ? 66.76300 54.69100 7.93000   1.000 19.10000 ? 105 GLY A CA  1 
ATOM   441  C C   . GLY A 1 61  ? 68.10000 54.44400 8.60000   1.000 18.55000 ? 105 GLY A C   1 
ATOM   442  O O   . GLY A 1 61  ? 68.54600 53.31100 8.78700   1.000 21.36000 ? 105 GLY A O   1 
ATOM   443  N N   . PHE A 1 62  ? 68.74800 55.54700 8.96300   1.000 19.96000 ? 106 PHE A N   1 
ATOM   444  C CA  . PHE A 1 62  ? 70.05100 55.48800 9.61200   1.000 19.67000 ? 106 PHE A CA  1 
ATOM   445  C C   . PHE A 1 62  ? 69.93400 54.81400 10.97400  1.000 22.06000 ? 106 PHE A C   1 
ATOM   446  O O   . PHE A 1 62  ? 69.10400 55.19900 11.80200  1.000 21.84000 ? 106 PHE A O   1 
ATOM   447  C CB  . PHE A 1 62  ? 70.61700 56.90300 9.75000   1.000 20.36000 ? 106 PHE A CB  1 
ATOM   448  C CG  . PHE A 1 62  ? 71.99600 56.96300 10.34700  1.000 22.46000 ? 106 PHE A CG  1 
ATOM   449  C CD1 . PHE A 1 62  ? 73.06400 56.32300 9.74000   1.000 21.24000 ? 106 PHE A CD1 1 
ATOM   450  C CD2 . PHE A 1 62  ? 72.23100 57.69400 11.50200  1.000 22.83000 ? 106 PHE A CD2 1 
ATOM   451  C CE1 . PHE A 1 62  ? 74.33300 56.39100 10.28600  1.000 22.11000 ? 106 PHE A CE1 1 
ATOM   452  C CE2 . PHE A 1 62  ? 73.49800 57.76600 12.05200  1.000 20.68000 ? 106 PHE A CE2 1 
ATOM   453  C CZ  . PHE A 1 62  ? 74.55000 57.11300 11.44300  1.000 23.08000 ? 106 PHE A CZ  1 
ATOM   454  N N   . THR A 1 63  ? 70.76300 53.79300 11.19500  1.000 23.34000 ? 107 THR A N   1 
ATOM   455  C CA  . THR A 1 63  ? 70.83000 52.97500 12.40700  1.000 22.74000 ? 107 THR A CA  1 
ATOM   456  C C   . THR A 1 63  ? 69.57600 52.14100 12.64500  1.000 24.42000 ? 107 THR A C   1 
ATOM   457  O O   . THR A 1 63  ? 69.48500 51.48100 13.68700  1.000 25.37000 ? 107 THR A O   1 
ATOM   458  C CB  . THR A 1 63  ? 71.09500 53.80300 13.67400  1.000 21.83000 ? 107 THR A CB  1 
ATOM   459  O OG1 . THR A 1 63  ? 69.94300 54.60100 13.97500  1.000 22.84000 ? 107 THR A OG1 1 
ATOM   460  C CG2 . THR A 1 63  ? 72.30300 54.70800 13.48500  1.000 21.11000 ? 107 THR A CG2 1 
ATOM   461  N N   . ALA A 1 64  ? 68.61400 52.13800 11.72900  1.000 23.90000 ? 108 ALA A N   1 
ATOM   462  C CA  . ALA A 1 64  ? 67.37500 51.39600 11.90700  1.000 18.51000 ? 108 ALA A CA  1 
ATOM   463  C C   . ALA A 1 64  ? 67.44500 50.04600 11.20200  1.000 21.48000 ? 108 ALA A C   1 
ATOM   464  O O   . ALA A 1 64  ? 68.24700 49.83100 10.29000  1.000 22.90000 ? 108 ALA A O   1 
ATOM   465  C CB  . ALA A 1 64  ? 66.18200 52.19900 11.38400  1.000 19.20000 ? 108 ALA A CB  1 
ATOM   466  N N   . SER A 1 65  ? 66.58300 49.13500 11.64000  1.000 20.72000 ? 109 SER A N   1 
ATOM   467  C CA  . SER A 1 65  ? 66.47400 47.79700 11.08100  1.000 20.73000 ? 109 SER A CA  1 
ATOM   468  C C   . SER A 1 65  ? 65.13700 47.64500 10.36300  1.000 18.78000 ? 109 SER A C   1 
ATOM   469  O O   . SER A 1 65  ? 64.32700 48.57400 10.30000  1.000 21.63000 ? 109 SER A O   1 
ATOM   470  C CB  . SER A 1 65  ? 66.62500 46.74400 12.18000  1.000 21.72000 ? 109 SER A CB  1 
ATOM   471  O OG  . SER A 1 65  ? 65.54100 46.81400 13.08800  1.000 25.78000 ? 109 SER A OG  1 
ATOM   472  N N   . GLN A 1 66  ? 64.90300 46.44400 9.82700   1.000 20.67000 ? 110 GLN A N   1 
ATOM   473  C CA  . GLN A 1 66  ? 63.66000 46.17300 9.11300   1.000 19.52000 ? 110 GLN A CA  1 
ATOM   474  C C   . GLN A 1 66  ? 62.43900 46.23300 10.02000  1.000 21.38000 ? 110 GLN A C   1 
ATOM   475  O O   . GLN A 1 66  ? 61.31700 46.35700 9.51700   1.000 18.30000 ? 110 GLN A O   1 
ATOM   476  C CB  . GLN A 1 66  ? 63.72400 44.80400 8.43800   1.000 21.63000 ? 110 GLN A CB  1 
ATOM   477  C CG  . GLN A 1 66  ? 63.95200 43.64900 9.39600   1.000 20.89000 ? 110 GLN A CG  1 
ATOM   478  C CD  . GLN A 1 66  ? 63.89500 42.30500 8.70300   1.000 20.02000 ? 110 GLN A CD  1 
ATOM   479  O OE1 . GLN A 1 66  ? 62.95900 42.01900 7.95800   1.000 23.22000 ? 110 GLN A OE1 1 
ATOM   480  N NE2 . GLN A 1 66  ? 64.90300 41.47300 8.93700   1.000 22.86000 ? 110 GLN A NE2 1 
ATOM   481  N N   . GLY A 1 67  ? 62.62600 46.14000 11.33900  1.000 23.33000 ? 111 GLY A N   1 
ATOM   482  C CA  . GLY A 1 67  ? 61.49400 46.23700 12.24200  1.000 18.18000 ? 111 GLY A CA  1 
ATOM   483  C C   . GLY A 1 67  ? 60.82200 47.59500 12.20600  1.000 16.85000 ? 111 GLY A C   1 
ATOM   484  O O   . GLY A 1 67  ? 59.63200 47.71100 12.50500  1.000 19.27000 ? 111 GLY A O   1 
ATOM   485  N N   . SER A 1 68  ? 61.56800 48.64000 11.84700  1.000 18.83000 ? 112 SER A N   1 
ATOM   486  C CA  . SER A 1 68  ? 60.97400 49.96600 11.74700  1.000 18.81000 ? 112 SER A CA  1 
ATOM   487  C C   . SER A 1 68  ? 60.09400 50.10600 10.51500  1.000 18.85000 ? 112 SER A C   1 
ATOM   488  O O   . SER A 1 68  ? 59.32700 51.06900 10.42200  1.000 20.91000 ? 112 SER A O   1 
ATOM   489  C CB  . SER A 1 68  ? 62.06700 51.03200 11.73000  1.000 19.57000 ? 112 SER A CB  1 
ATOM   490  O OG  . SER A 1 68  ? 62.98300 50.79300 10.67700  1.000 21.71000 ? 112 SER A OG  1 
ATOM   491  N N   . MET A 1 69  ? 60.19400 49.16800 9.57200   1.000 22.28000 ? 113 MET A N   1 
ATOM   492  C CA  . MET A 1 69  ? 59.39500 49.17100 8.35500   1.000 19.66000 ? 113 MET A CA  1 
ATOM   493  C C   . MET A 1 69  ? 58.52400 47.92400 8.25400   1.000 19.96000 ? 113 MET A C   1 
ATOM   494  O O   . MET A 1 69  ? 58.00100 47.62100 7.17700   1.000 23.06000 ? 113 MET A O   1 
ATOM   495  C CB  . MET A 1 69  ? 60.30400 49.28700 7.12900   1.000 20.45000 ? 113 MET A CB  1 
ATOM   496  C CG  . MET A 1 69  ? 61.38000 50.35600 7.24400   1.000 17.44000 ? 113 MET A CG  1 
ATOM   497  S SD  . MET A 1 69  ? 60.71700 52.02900 7.32900   1.000 23.13000 ? 113 MET A SD  1 
ATOM   498  C CE  . MET A 1 69  ? 60.05100 52.22600 5.67800   1.000 22.72000 ? 113 MET A CE  1 
ATOM   499  N N   . SER A 1 70  ? 58.36200 47.19300 9.35900   1.000 21.75000 ? 114 SER A N   1 
ATOM   500  C CA  . SER A 1 70  ? 57.71100 45.88800 9.29800   1.000 19.04000 ? 114 SER A CA  1 
ATOM   501  C C   . SER A 1 70  ? 56.22700 45.99800 8.97800   1.000 19.33000 ? 114 SER A C   1 
ATOM   502  O O   . SER A 1 70  ? 55.66500 45.08900 8.35600   1.000 23.02000 ? 114 SER A O   1 
ATOM   503  C CB  . SER A 1 70  ? 57.90900 45.14200 10.61600  1.000 20.49000 ? 114 SER A CB  1 
ATOM   504  O OG  . SER A 1 70  ? 57.32700 45.86000 11.69000  1.000 24.17000 ? 114 SER A OG  1 
ATOM   505  N N   . TRP A 1 71  ? 55.57200 47.08700 9.38800   1.000 20.67000 ? 115 TRP A N   1 
ATOM   506  C CA  . TRP A 1 71  ? 54.13200 47.18900 9.18500   1.000 20.33000 ? 115 TRP A CA  1 
ATOM   507  C C   . TRP A 1 71  ? 53.76400 47.35600 7.71800   1.000 21.59000 ? 115 TRP A C   1 
ATOM   508  O O   . TRP A 1 71  ? 52.61000 47.11100 7.35300   1.000 22.40000 ? 115 TRP A O   1 
ATOM   509  C CB  . TRP A 1 71  ? 53.55100 48.34100 10.00900  1.000 20.77000 ? 115 TRP A CB  1 
ATOM   510  C CG  . TRP A 1 71  ? 53.84000 49.71100 9.47400   1.000 17.00000 ? 115 TRP A CG  1 
ATOM   511  C CD1 . TRP A 1 71  ? 54.97300 50.44300 9.66500   1.000 17.74000 ? 115 TRP A CD1 1 
ATOM   512  C CD2 . TRP A 1 71  ? 52.96700 50.52200 8.67800   1.000 18.11000 ? 115 TRP A CD2 1 
ATOM   513  N NE1 . TRP A 1 71  ? 54.86500 51.65700 9.03100   1.000 17.14000 ? 115 TRP A NE1 1 
ATOM   514  C CE2 . TRP A 1 71  ? 53.64200 51.73000 8.41700   1.000 16.36000 ? 115 TRP A CE2 1 
ATOM   515  C CE3 . TRP A 1 71  ? 51.68200 50.34000 8.15600   1.000 17.94000 ? 115 TRP A CE3 1 
ATOM   516  C CZ2 . TRP A 1 71  ? 53.07600 52.75200 7.66000   1.000 16.79000 ? 115 TRP A CZ2 1 
ATOM   517  C CZ3 . TRP A 1 71  ? 51.12200 51.35700 7.40400   1.000 18.20000 ? 115 TRP A CZ3 1 
ATOM   518  C CH2 . TRP A 1 71  ? 51.81900 52.54700 7.16200   1.000 18.37000 ? 115 TRP A CH2 1 
ATOM   519  N N   . TYR A 1 72  ? 54.71400 47.76200 6.87200   1.000 22.05000 ? 116 TYR A N   1 
ATOM   520  C CA  . TYR A 1 72  ? 54.44800 47.81500 5.43900   1.000 20.44000 ? 116 TYR A CA  1 
ATOM   521  C C   . TYR A 1 72  ? 54.29900 46.42100 4.84500   1.000 23.90000 ? 116 TYR A C   1 
ATOM   522  O O   . TYR A 1 72  ? 53.62000 46.25500 3.82500   1.000 27.15000 ? 116 TYR A O   1 
ATOM   523  C CB  . TYR A 1 72  ? 55.56600 48.56800 4.72000   1.000 17.95000 ? 116 TYR A CB  1 
ATOM   524  C CG  . TYR A 1 72  ? 55.65900 50.03500 5.06500   1.000 17.72000 ? 116 TYR A CG  1 
ATOM   525  C CD1 . TYR A 1 72  ? 54.82700 50.96500 4.45800   1.000 16.28000 ? 116 TYR A CD1 1 
ATOM   526  C CD2 . TYR A 1 72  ? 56.58800 50.49100 5.98800   1.000 18.21000 ? 116 TYR A CD2 1 
ATOM   527  C CE1 . TYR A 1 72  ? 54.91300 52.30800 4.76700   1.000 17.70000 ? 116 TYR A CE1 1 
ATOM   528  C CE2 . TYR A 1 72  ? 56.68000 51.82900 6.30300   1.000 17.97000 ? 116 TYR A CE2 1 
ATOM   529  C CZ  . TYR A 1 72  ? 55.84300 52.73300 5.69100   1.000 17.06000 ? 116 TYR A CZ  1 
ATOM   530  O OH  . TYR A 1 72  ? 55.93700 54.06800 6.00700   1.000 18.79000 ? 116 TYR A OH  1 
ATOM   531  N N   . GLY A 1 73  ? 54.92300 45.41700 5.46000   1.000 22.22000 ? 117 GLY A N   1 
ATOM   532  C CA  . GLY A 1 73  ? 54.89000 44.05400 4.96400   1.000 21.70000 ? 117 GLY A CA  1 
ATOM   533  C C   . GLY A 1 73  ? 53.49800 43.50900 4.71900   1.000 24.16000 ? 117 GLY A C   1 
ATOM   534  O O   . GLY A 1 73  ? 53.07400 43.38800 3.56800   1.000 26.11000 ? 117 GLY A O   1 
ATOM   535  N N   . GLU A 1 74  ? 52.77500 43.18000 5.79200   1.000 22.80000 ? 118 GLU A N   1 
ATOM   536  C CA  . GLU A 1 74  ? 51.42500 42.64500 5.64100   1.000 22.95000 ? 118 GLU A CA  1 
ATOM   537  C C   . GLU A 1 74  ? 50.47000 43.67300 5.04700   1.000 24.49000 ? 118 GLU A C   1 
ATOM   538  O O   . GLU A 1 74  ? 49.51700 43.30200 4.35400   1.000 26.19000 ? 118 GLU A O   1 
ATOM   539  C CB  . GLU A 1 74  ? 50.90000 42.16200 6.99300   1.000 26.00000 ? 118 GLU A CB  1 
ATOM   540  C CG  . GLU A 1 74  ? 51.77700 41.12500 7.67600   1.000 25.71000 ? 118 GLU A CG  1 
ATOM   541  C CD  . GLU A 1 74  ? 51.43800 39.71100 7.25800   1.000 25.76000 ? 118 GLU A CD  1 
ATOM   542  O OE1 . GLU A 1 74  ? 50.33400 39.50000 6.71300   1.000 29.22000 ? 118 GLU A OE1 1 
ATOM   543  O OE2 . GLU A 1 74  ? 52.27300 38.81000 7.47500   1.000 27.11000 ? 118 GLU A OE2 1 
ATOM   544  N N   . ARG A 1 75  ? 50.70600 44.96100 5.30600   1.000 24.67000 ? 119 ARG A N   1 
ATOM   545  C CA  . ARG A 1 75  ? 49.79900 46.00300 4.83000   1.000 25.82000 ? 119 ARG A CA  1 
ATOM   546  C C   . ARG A 1 75  ? 49.79900 46.08200 3.30700   1.000 24.89000 ? 119 ARG A C   1 
ATOM   547  O O   . ARG A 1 75  ? 48.73700 46.07800 2.67300   1.000 25.06000 ? 119 ARG A O   1 
ATOM   548  C CB  . ARG A 1 75  ? 50.19600 47.35000 5.43600   1.000 22.75000 ? 119 ARG A CB  1 
ATOM   549  C CG  . ARG A 1 75  ? 49.19200 48.47700 5.24000   1.000 24.36000 ? 119 ARG A CG  1 
ATOM   550  C CD  . ARG A 1 75  ? 48.01000 48.33100 6.18000   1.000 22.12000 ? 119 ARG A CD  1 
ATOM   551  N NE  . ARG A 1 75  ? 47.11400 49.48000 6.12800   1.000 24.42000 ? 119 ARG A NE  1 
ATOM   552  C CZ  . ARG A 1 75  ? 46.99600 50.38300 7.09100   1.000 22.91000 ? 119 ARG A CZ  1 
ATOM   553  N NH1 . ARG A 1 75  ? 47.69000 50.29200 8.21400   1.000 23.79000 ? 119 ARG A NH1 1 
ATOM   554  N NH2 . ARG A 1 75  ? 46.15500 51.40000 6.92700   1.000 21.85000 ? 119 ARG A NH2 1 
ATOM   555  N N   . VAL A 1 76  ? 50.98500 46.15400 2.70300   1.000 25.32000 ? 120 VAL A N   1 
ATOM   556  C CA  . VAL A 1 76  ? 51.07600 46.33100 1.25800   1.000 24.28000 ? 120 VAL A CA  1 
ATOM   557  C C   . VAL A 1 76  ? 50.94000 44.99800 0.53400   1.000 25.44000 ? 120 VAL A C   1 
ATOM   558  O O   . VAL A 1 76  ? 50.27900 44.91300 -0.50700  1.000 26.68000 ? 120 VAL A O   1 
ATOM   559  C CB  . VAL A 1 76  ? 52.39300 47.04300 0.89800   1.000 24.48000 ? 120 VAL A CB  1 
ATOM   560  C CG1 . VAL A 1 76  ? 52.58400 47.08800 -0.61100  1.000 25.79000 ? 120 VAL A CG1 1 
ATOM   561  C CG2 . VAL A 1 76  ? 52.41000 48.44800 1.48300   1.000 21.13000 ? 120 VAL A CG2 1 
ATOM   562  N N   . ALA A 1 77  ? 51.55300 43.93800 1.06700   1.000 24.50000 ? 121 ALA A N   1 
ATOM   563  C CA  . ALA A 1 77  ? 51.53000 42.65400 0.37500   1.000 24.33000 ? 121 ALA A CA  1 
ATOM   564  C C   . ALA A 1 77  ? 50.12600 42.06600 0.30700   1.000 25.79000 ? 121 ALA A C   1 
ATOM   565  O O   . ALA A 1 77  ? 49.81200 41.33200 -0.63600  1.000 28.21000 ? 121 ALA A O   1 
ATOM   566  C CB  . ALA A 1 77  ? 52.48300 41.66800 1.04800   1.000 22.54000 ? 121 ALA A CB  1 
ATOM   567  N N   . SER A 1 78  ? 49.26800 42.37400 1.28300   1.000 26.37000 ? 122 SER A N   1 
ATOM   568  C CA  . SER A 1 78  ? 47.90400 41.86100 1.25100   1.000 27.78000 ? 122 SER A CA  1 
ATOM   569  C C   . SER A 1 78  ? 47.06600 42.48800 0.14800   1.000 26.11000 ? 122 SER A C   1 
ATOM   570  O O   . SER A 1 78  ? 45.97700 41.98200 -0.14000  1.000 27.14000 ? 122 SER A O   1 
ATOM   571  C CB  . SER A 1 78  ? 47.21900 42.08000 2.60000   1.000 26.17000 ? 122 SER A CB  1 
ATOM   572  O OG  . SER A 1 78  ? 47.08100 43.46200 2.88000   1.000 25.96000 ? 122 SER A OG  1 
ATOM   573  N N   . HIS A 1 79  ? 47.53700 43.57000 -0.46600  1.000 27.26000 ? 123 HIS A N   1 
ATOM   574  C CA  . HIS A 1 79  ? 46.85200 44.18500 -1.59300  1.000 28.13000 ? 123 HIS A CA  1 
ATOM   575  C C   . HIS A 1 79  ? 47.38000 43.69700 -2.93600  1.000 28.90000 ? 123 HIS A C   1 
ATOM   576  O O   . HIS A 1 79  ? 46.97000 44.22100 -3.97600  1.000 30.59000 ? 123 HIS A O   1 
ATOM   577  C CB  . HIS A 1 79  ? 46.95900 45.71000 -1.50900  1.000 26.78000 ? 123 HIS A CB  1 
ATOM   578  C CG  . HIS A 1 79  ? 46.07000 46.32100 -0.47000  1.000 27.75000 ? 123 HIS A CG  1 
ATOM   579  N ND1 . HIS A 1 79  ? 46.35700 46.27600 0.87800   1.000 27.88000 ? 123 HIS A ND1 1 
ATOM   580  C CD2 . HIS A 1 79  ? 44.89900 46.99100 -0.58200  1.000 27.83000 ? 123 HIS A CD2 1 
ATOM   581  C CE1 . HIS A 1 79  ? 45.40100 46.89300 1.55000   1.000 28.32000 ? 123 HIS A CE1 1 
ATOM   582  N NE2 . HIS A 1 79  ? 44.50400 47.33600 0.68800   1.000 28.77000 ? 123 HIS A NE2 1 
ATOM   583  N N   . GLY A 1 80  ? 48.27700 42.71200 -2.93800  1.000 28.25000 ? 124 GLY A N   1 
ATOM   584  C CA  . GLY A 1 80  ? 48.75500 42.12100 -4.17300  1.000 27.21000 ? 124 GLY A CA  1 
ATOM   585  C C   . GLY A 1 80  ? 50.15000 42.55500 -4.57000  1.000 28.44000 ? 124 GLY A C   1 
ATOM   586  O O   . GLY A 1 80  ? 50.36800 43.00500 -5.69900  1.000 28.18000 ? 124 GLY A O   1 
ATOM   587  N N   . PHE A 1 81  ? 51.10700 42.42000 -3.65500  1.000 25.13000 ? 125 PHE A N   1 
ATOM   588  C CA  . PHE A 1 81  ? 52.48500 42.79300 -3.93400  1.000 25.21000 ? 125 PHE A CA  1 
ATOM   589  C C   . PHE A 1 81  ? 53.41800 41.89000 -3.14400  1.000 24.10000 ? 125 PHE A C   1 
ATOM   590  O O   . PHE A 1 81  ? 53.02800 41.27100 -2.15200  1.000 25.94000 ? 125 PHE A O   1 
ATOM   591  C CB  . PHE A 1 81  ? 52.77100 44.25900 -3.58000  1.000 27.88000 ? 125 PHE A CB  1 
ATOM   592  C CG  . PHE A 1 81  ? 52.05000 45.25300 -4.44500  1.000 27.32000 ? 125 PHE A CG  1 
ATOM   593  C CD1 . PHE A 1 81  ? 52.50800 45.54500 -5.71900  1.000 28.52000 ? 125 PHE A CD1 1 
ATOM   594  C CD2 . PHE A 1 81  ? 50.92600 45.91200 -3.97500  1.000 26.98000 ? 125 PHE A CD2 1 
ATOM   595  C CE1 . PHE A 1 81  ? 51.85000 46.46500 -6.51300  1.000 26.31000 ? 125 PHE A CE1 1 
ATOM   596  C CE2 . PHE A 1 81  ? 50.26500 46.83300 -4.76300  1.000 25.17000 ? 125 PHE A CE2 1 
ATOM   597  C CZ  . PHE A 1 81  ? 50.72800 47.11000 -6.03300  1.000 25.78000 ? 125 PHE A CZ  1 
ATOM   598  N N   . ILE A 1 82  ? 54.66300 41.82600 -3.60100  1.000 24.46000 ? 126 ILE A N   1 
ATOM   599  C CA  . ILE A 1 82  ? 55.74300 41.18400 -2.86500  1.000 24.01000 ? 126 ILE A CA  1 
ATOM   600  C C   . ILE A 1 82  ? 56.55100 42.27700 -2.18200  1.000 23.62000 ? 126 ILE A C   1 
ATOM   601  O O   . ILE A 1 82  ? 57.02100 43.21400 -2.83800  1.000 24.22000 ? 126 ILE A O   1 
ATOM   602  C CB  . ILE A 1 82  ? 56.62700 40.33600 -3.79300  1.000 24.56000 ? 126 ILE A CB  1 
ATOM   603  C CG1 . ILE A 1 82  ? 55.79900 39.22400 -4.44000  1.000 24.50000 ? 126 ILE A CG1 1 
ATOM   604  C CG2 . ILE A 1 82  ? 57.80800 39.76100 -3.02500  1.000 24.88000 ? 126 ILE A CG2 1 
ATOM   605  C CD1 . ILE A 1 82  ? 56.53300 38.47800 -5.52900  1.000 25.07000 ? 126 ILE A CD1 1 
ATOM   606  N N   . VAL A 1 83  ? 56.69900 42.17300 -0.86600  1.000 24.90000 ? 127 VAL A N   1 
ATOM   607  C CA  . VAL A 1 83  ? 57.33800 43.20900 -0.06400  1.000 21.65000 ? 127 VAL A CA  1 
ATOM   608  C C   . VAL A 1 83  ? 58.58000 42.62100 0.58700   1.000 21.71000 ? 127 VAL A C   1 
ATOM   609  O O   . VAL A 1 83  ? 58.51400 41.55900 1.21700   1.000 23.58000 ? 127 VAL A O   1 
ATOM   610  C CB  . VAL A 1 83  ? 56.37500 43.77900 0.99300   1.000 22.76000 ? 127 VAL A CB  1 
ATOM   611  C CG1 . VAL A 1 83  ? 57.10400 44.75100 1.90300   1.000 20.88000 ? 127 VAL A CG1 1 
ATOM   612  C CG2 . VAL A 1 83  ? 55.19900 44.46300 0.31500   1.000 23.19000 ? 127 VAL A CG2 1 
ATOM   613  N N   . PHE A 1 84  ? 59.70600 43.31200 0.43500   1.000 20.74000 ? 128 PHE A N   1 
ATOM   614  C CA  . PHE A 1 84  ? 61.00300 42.85400 0.92500   1.000 20.47000 ? 128 PHE A CA  1 
ATOM   615  C C   . PHE A 1 84  ? 61.55900 43.93500 1.84800   1.000 19.55000 ? 128 PHE A C   1 
ATOM   616  O O   . PHE A 1 84  ? 62.26200 44.84500 1.40500   1.000 21.26000 ? 128 PHE A O   1 
ATOM   617  C CB  . PHE A 1 84  ? 61.95200 42.55900 -0.24200  1.000 20.34000 ? 128 PHE A CB  1 
ATOM   618  C CG  . PHE A 1 84  ? 63.09400 41.64300 0.10900   1.000 21.60000 ? 128 PHE A CG  1 
ATOM   619  C CD1 . PHE A 1 84  ? 63.29200 41.21400 1.41200   1.000 21.57000 ? 128 PHE A CD1 1 
ATOM   620  C CD2 . PHE A 1 84  ? 63.97300 41.21200 -0.87100  1.000 20.79000 ? 128 PHE A CD2 1 
ATOM   621  C CE1 . PHE A 1 84  ? 64.34400 40.37300 1.72900   1.000 21.10000 ? 128 PHE A CE1 1 
ATOM   622  C CE2 . PHE A 1 84  ? 65.02600 40.37100 -0.56000  1.000 23.38000 ? 128 PHE A CE2 1 
ATOM   623  C CZ  . PHE A 1 84  ? 65.21100 39.95100 0.74100   1.000 22.60000 ? 128 PHE A CZ  1 
ATOM   624  N N   . THR A 1 85  ? 61.23300 43.83200 3.13400   1.000 20.91000 ? 129 THR A N   1 
ATOM   625  C CA  . THR A 1 85  ? 61.80700 44.70900 4.15000   1.000 20.10000 ? 129 THR A CA  1 
ATOM   626  C C   . THR A 1 85  ? 63.20300 44.20200 4.48200   1.000 18.79000 ? 129 THR A C   1 
ATOM   627  O O   . THR A 1 85  ? 63.35800 43.10700 5.03200   1.000 21.18000 ? 129 THR A O   1 
ATOM   628  C CB  . THR A 1 85  ? 60.92300 44.74300 5.39200   1.000 18.18000 ? 129 THR A CB  1 
ATOM   629  O OG1 . THR A 1 85  ? 60.75200 43.41100 5.89100   1.000 20.06000 ? 129 THR A OG1 1 
ATOM   630  C CG2 . THR A 1 85  ? 59.56400 45.33100 5.05700   1.000 18.18000 ? 129 THR A CG2 1 
ATOM   631  N N   . ILE A 1 86  ? 64.22000 44.99100 4.15200   1.000 18.49000 ? 130 ILE A N   1 
ATOM   632  C CA  . ILE A 1 86  ? 65.59900 44.54000 4.23000   1.000 19.75000 ? 130 ILE A CA  1 
ATOM   633  C C   . ILE A 1 86  ? 66.31400 45.24500 5.37400   1.000 16.81000 ? 130 ILE A C   1 
ATOM   634  O O   . ILE A 1 86  ? 65.91000 46.31300 5.84200   1.000 18.94000 ? 130 ILE A O   1 
ATOM   635  C CB  . ILE A 1 86  ? 66.35500 44.76900 2.90500   1.000 19.97000 ? 130 ILE A CB  1 
ATOM   636  C CG1 . ILE A 1 86  ? 66.57300 46.26500 2.66700   1.000 21.28000 ? 130 ILE A CG1 1 
ATOM   637  C CG2 . ILE A 1 86  ? 65.59100 44.15600 1.75000   1.000 20.17000 ? 130 ILE A CG2 1 
ATOM   638  C CD1 . ILE A 1 86  ? 67.54900 46.57100 1.55200   1.000 20.55000 ? 130 ILE A CD1 1 
ATOM   639  N N   . ASP A 1 87  ? 67.39100 44.61700 5.82800   1.000 20.32000 ? 131 ASP A N   1 
ATOM   640  C CA  . ASP A 1 87  ? 68.37000 45.24100 6.70000   1.000 20.54000 ? 131 ASP A CA  1 
ATOM   641  C C   . ASP A 1 87  ? 69.59700 45.61300 5.88000   1.000 20.62000 ? 131 ASP A C   1 
ATOM   642  O O   . ASP A 1 87  ? 69.93600 44.94200 4.90200   1.000 22.20000 ? 131 ASP A O   1 
ATOM   643  C CB  . ASP A 1 87  ? 68.77500 44.30600 7.84300   1.000 21.66000 ? 131 ASP A CB  1 
ATOM   644  C CG  . ASP A 1 87  ? 67.65800 44.08100 8.84100   1.000 21.25000 ? 131 ASP A CG  1 
ATOM   645  O OD1 . ASP A 1 87  ? 66.95400 45.05500 9.18000   1.000 22.74000 ? 131 ASP A OD1 1 
ATOM   646  O OD2 . ASP A 1 87  ? 67.48500 42.92600 9.28600   1.000 22.97000 ? 131 ASP A OD2 1 
ATOM   647  N N   . THR A 1 88  ? 70.25800 46.69200 6.28000   1.000 21.28000 ? 132 THR A N   1 
ATOM   648  C CA  . THR A 1 88  ? 71.46800 47.09300 5.58700   1.000 21.05000 ? 132 THR A CA  1 
ATOM   649  C C   . THR A 1 88  ? 72.66300 46.28900 6.09300   1.000 21.16000 ? 132 THR A C   1 
ATOM   650  O O   . THR A 1 88  ? 72.60700 45.63200 7.13700   1.000 23.01000 ? 132 THR A O   1 
ATOM   651  C CB  . THR A 1 88  ? 71.72000 48.59100 5.75600   1.000 22.77000 ? 132 THR A CB  1 
ATOM   652  O OG1 . THR A 1 88  ? 71.63200 48.94600 7.14200   1.000 24.33000 ? 132 THR A OG1 1 
ATOM   653  C CG2 . THR A 1 88  ? 70.69500 49.38900 4.96500   1.000 20.99000 ? 132 THR A CG2 1 
ATOM   654  N N   . ASN A 1 89  ? 73.75100 46.33200 5.31800   1.000 20.71000 ? 133 ASN A N   1 
ATOM   655  C CA  . ASN A 1 89  ? 74.96600 45.61600 5.69700   1.000 22.11000 ? 133 ASN A CA  1 
ATOM   656  C C   . ASN A 1 89  ? 75.45100 46.05700 7.07000   1.000 22.11000 ? 133 ASN A C   1 
ATOM   657  O O   . ASN A 1 89  ? 75.79300 45.22700 7.92100   1.000 23.65000 ? 133 ASN A O   1 
ATOM   658  C CB  . ASN A 1 89  ? 76.05500 45.83300 4.64700   1.000 25.06000 ? 133 ASN A CB  1 
ATOM   659  C CG  . ASN A 1 89  ? 75.77800 45.09100 3.35700   1.000 24.94000 ? 133 ASN A CG  1 
ATOM   660  O OD1 . ASN A 1 89  ? 75.27500 43.96800 3.36900   1.000 26.57000 ? 133 ASN A OD1 1 
ATOM   661  N ND2 . ASN A 1 89  ? 76.10600 45.71600 2.23300   1.000 26.90000 ? 133 ASN A ND2 1 
ATOM   662  N N   . THR A 1 90  ? 75.50400 47.36600 7.29800   1.000 24.93000 ? 134 THR A N   1 
ATOM   663  C CA  . THR A 1 90  ? 75.74400 47.92900 8.61600   1.000 24.31000 ? 134 THR A CA  1 
ATOM   664  C C   . THR A 1 90  ? 74.68800 48.98700 8.88800   1.000 25.29000 ? 134 THR A C   1 
ATOM   665  O O   . THR A 1 90  ? 74.12900 49.58200 7.96300   1.000 23.22000 ? 134 THR A O   1 
ATOM   666  C CB  . THR A 1 90  ? 77.14300 48.55700 8.74800   1.000 20.78000 ? 134 THR A CB  1 
ATOM   667  O OG1 . THR A 1 90  ? 77.19800 49.77200 7.99200   1.000 25.33000 ? 134 THR A OG1 1 
ATOM   668  C CG2 . THR A 1 90  ? 78.21700 47.60200 8.25100   1.000 23.59000 ? 134 THR A CG2 1 
ATOM   669  N N   . ARG A 1 91  ? 74.41900 49.21800 10.17200  1.000 25.68000 ? 135 ARG A N   1 
ATOM   670  C CA  . ARG A 1 91  ? 73.41400 50.20100 10.55000  1.000 25.67000 ? 135 ARG A CA  1 
ATOM   671  C C   . ARG A 1 91  ? 73.83200 51.62300 10.19800  1.000 22.52000 ? 135 ARG A C   1 
ATOM   672  O O   . ARG A 1 91  ? 72.97900 52.51500 10.16000  1.000 23.31000 ? 135 ARG A O   1 
ATOM   673  C CB  . ARG A 1 91  ? 73.12500 50.08300 12.04600  1.000 26.66000 ? 135 ARG A CB  1 
ATOM   674  C CG  . ARG A 1 91  ? 74.37400 49.88300 12.89000  1.000 30.04000 ? 135 ARG A CG  1 
ATOM   675  C CD  . ARG A 1 91  ? 74.03700 49.39100 14.29000  1.000 34.30000 ? 135 ARG A CD  1 
ATOM   676  N NE  . ARG A 1 91  ? 73.25700 50.36600 15.04200  1.000 32.34000 ? 135 ARG A NE  1 
ATOM   677  C CZ  . ARG A 1 91  ? 73.78000 51.35300 15.75600  1.000 30.27000 ? 135 ARG A CZ  1 
ATOM   678  N NH1 . ARG A 1 91  ? 75.08900 51.53200 15.83300  1.000 30.28000 ? 135 ARG A NH1 1 
ATOM   679  N NH2 . ARG A 1 91  ? 72.97000 52.18400 16.40500  1.000 29.25000 ? 135 ARG A NH2 1 
ATOM   680  N N   . LEU A 1 92  ? 75.11400 51.85200 9.92100   1.000 22.67000 ? 136 LEU A N   1 
ATOM   681  C CA  . LEU A 1 92  ? 75.63500 53.18800 9.66700   1.000 20.87000 ? 136 LEU A CA  1 
ATOM   682  C C   . LEU A 1 92  ? 75.74500 53.50800 8.18000   1.000 21.62000 ? 136 LEU A C   1 
ATOM   683  O O   . LEU A 1 92  ? 76.42800 54.46900 7.81100   1.000 22.62000 ? 136 LEU A O   1 
ATOM   684  C CB  . LEU A 1 92  ? 76.99800 53.34900 10.33900  1.000 22.14000 ? 136 LEU A CB  1 
ATOM   685  C CG  . LEU A 1 92  ? 77.05500 53.03300 11.83500  1.000 22.99000 ? 136 LEU A CG  1 
ATOM   686  C CD1 . LEU A 1 92  ? 78.48500 53.11700 12.34000  1.000 21.76000 ? 136 LEU A CD1 1 
ATOM   687  C CD2 . LEU A 1 92  ? 76.15200 53.96800 12.62400  1.000 23.05000 ? 136 LEU A CD2 1 
ATOM   688  N N   . ASP A 1 93  ? 75.08200 52.73500 7.32400   1.000 23.21000 ? 137 ASP A N   1 
ATOM   689  C CA  . ASP A 1 93  ? 75.24000 52.89700 5.88500   1.000 22.22000 ? 137 ASP A CA  1 
ATOM   690  C C   . ASP A 1 93  ? 74.63100 54.21000 5.41000   1.000 20.06000 ? 137 ASP A C   1 
ATOM   691  O O   . ASP A 1 93  ? 73.60200 54.66200 5.91900   1.000 22.55000 ? 137 ASP A O   1 
ATOM   692  C CB  . ASP A 1 93  ? 74.60000 51.72400 5.14700   1.000 20.10000 ? 137 ASP A CB  1 
ATOM   693  C CG  . ASP A 1 93  ? 75.43200 50.46400 5.23600   1.000 20.63000 ? 137 ASP A CG  1 
ATOM   694  O OD1 . ASP A 1 93  ? 76.56600 50.53200 5.75500   1.000 21.12000 ? 137 ASP A OD1 1 
ATOM   695  O OD2 . ASP A 1 93  ? 74.95300 49.40400 4.78200   1.000 21.70000 ? 137 ASP A OD2 1 
ATOM   696  N N   . ALA A 1 94  ? 75.27600 54.81900 4.42500   1.000 21.20000 ? 138 ALA A N   1 
ATOM   697  C CA  . ALA A 1 94  ? 74.85300 56.09900 3.87700   1.000 19.58000 ? 138 ALA A CA  1 
ATOM   698  C C   . ALA A 1 94  ? 73.79500 55.87700 2.80200   1.000 20.88000 ? 138 ALA A C   1 
ATOM   699  O O   . ALA A 1 94  ? 73.56600 54.74700 2.36300   1.000 21.64000 ? 138 ALA A O   1 
ATOM   700  C CB  . ALA A 1 94  ? 76.07100 56.84100 3.33200   1.000 21.34000 ? 138 ALA A CB  1 
ATOM   701  N N   . PRO A 1 95  ? 73.10300 56.94200 2.36700   1.000 20.32000 ? 139 PRO A N   1 
ATOM   702  C CA  . PRO A 1 95  ? 72.08400 56.76800 1.31400   1.000 20.96000 ? 139 PRO A CA  1 
ATOM   703  C C   . PRO A 1 95  ? 72.59600 56.09800 0.04900   1.000 19.90000 ? 139 PRO A C   1 
ATOM   704  O O   . PRO A 1 95  ? 71.89100 55.25800 -0.52400  1.000 19.59000 ? 139 PRO A O   1 
ATOM   705  C CB  . PRO A 1 95  ? 71.62700 58.20600 1.04300   1.000 19.22000 ? 139 PRO A CB  1 
ATOM   706  C CG  . PRO A 1 95  ? 71.82000 58.89900 2.32900   1.000 20.07000 ? 139 PRO A CG  1 
ATOM   707  C CD  . PRO A 1 95  ? 73.06200 58.30200 2.93500   1.000 20.25000 ? 139 PRO A CD  1 
ATOM   708  N N   . GLY A 1 96  ? 73.80000 56.45000 -0.40600  1.000 21.28000 ? 140 GLY A N   1 
ATOM   709  C CA  . GLY A 1 96  ? 74.33100 55.83100 -1.61000  1.000 20.89000 ? 140 GLY A CA  1 
ATOM   710  C C   . GLY A 1 96  ? 74.50100 54.33100 -1.46700  1.000 22.93000 ? 140 GLY A C   1 
ATOM   711  O O   . GLY A 1 96  ? 74.21400 53.57200 -2.39600  1.000 22.16000 ? 140 GLY A O   1 
ATOM   712  N N   . GLN A 1 97  ? 74.96600 53.88300 -0.29900  1.000 24.08000 ? 141 GLN A N   1 
ATOM   713  C CA  . GLN A 1 97  ? 75.07500 52.45100 -0.04200  1.000 21.53000 ? 141 GLN A CA  1 
ATOM   714  C C   . GLN A 1 97  ? 73.70000 51.80200 0.05500   1.000 21.02000 ? 141 GLN A C   1 
ATOM   715  O O   . GLN A 1 97  ? 73.50600 50.67400 -0.41300  1.000 20.92000 ? 141 GLN A O   1 
ATOM   716  C CB  . GLN A 1 97  ? 75.87300 52.20700 1.23900   1.000 20.85000 ? 141 GLN A CB  1 
ATOM   717  C CG  . GLN A 1 97  ? 77.28700 52.76200 1.21100   1.000 23.18000 ? 141 GLN A CG  1 
ATOM   718  C CD  . GLN A 1 97  ? 77.93300 52.78500 2.58500   1.000 25.04000 ? 141 GLN A CD  1 
ATOM   719  O OE1 . GLN A 1 97  ? 77.44600 53.44700 3.50200   1.000 24.00000 ? 141 GLN A OE1 1 
ATOM   720  N NE2 . GLN A 1 97  ? 79.03500 52.06000 2.73300   1.000 26.02000 ? 141 GLN A NE2 1 
ATOM   721  N N   . ARG A 1 98  ? 72.73100 52.49500 0.65800   1.000 18.43000 ? 142 ARG A N   1 
ATOM   722  C CA  . ARG A 1 98  ? 71.40200 51.91100 0.80200   1.000 19.47000 ? 142 ARG A CA  1 
ATOM   723  C C   . ARG A 1 98  ? 70.70100 51.76600 -0.54300  1.000 18.33000 ? 142 ARG A C   1 
ATOM   724  O O   . ARG A 1 98  ? 69.84500 50.88900 -0.70200  1.000 18.29000 ? 142 ARG A O   1 
ATOM   725  C CB  . ARG A 1 98  ? 70.56200 52.75000 1.76500   1.000 19.40000 ? 142 ARG A CB  1 
ATOM   726  C CG  . ARG A 1 98  ? 71.12200 52.77400 3.17600   1.000 19.41000 ? 142 ARG A CG  1 
ATOM   727  C CD  . ARG A 1 98  ? 70.40500 53.77100 4.06500   1.000 20.18000 ? 142 ARG A CD  1 
ATOM   728  N NE  . ARG A 1 98  ? 71.04100 53.83700 5.37500   1.000 22.44000 ? 142 ARG A NE  1 
ATOM   729  C CZ  . ARG A 1 98  ? 70.69100 53.09300 6.41500   1.000 21.75000 ? 142 ARG A CZ  1 
ATOM   730  N NH1 . ARG A 1 98  ? 69.66700 52.25700 6.35400   1.000 21.70000 ? 142 ARG A NH1 1 
ATOM   731  N NH2 . ARG A 1 98  ? 71.38600 53.18900 7.54500   1.000 21.90000 ? 142 ARG A NH2 1 
ATOM   732  N N   . GLY A 1 99  ? 71.05100 52.60300 -1.52100  1.000 21.78000 ? 143 GLY A N   1 
ATOM   733  C CA  . GLY A 1 99  ? 70.50000 52.42900 -2.85500  1.000 20.62000 ? 143 GLY A CA  1 
ATOM   734  C C   . GLY A 1 99  ? 71.04100 51.19200 -3.54600  1.000 19.09000 ? 143 GLY A C   1 
ATOM   735  O O   . GLY A 1 99  ? 70.30600 50.48800 -4.24400  1.000 20.21000 ? 143 GLY A O   1 
ATOM   736  N N   . ARG A 1 100 ? 72.33300 50.91000 -3.35800  1.000 21.11000 ? 144 ARG A N   1 
ATOM   737  C CA  . ARG A 1 100 ? 72.92400 49.69800 -3.91700  1.000 21.22000 ? 144 ARG A CA  1 
ATOM   738  C C   . ARG A 1 100 ? 72.30800 48.44800 -3.30500  1.000 21.72000 ? 144 ARG A C   1 
ATOM   739  O O   . ARG A 1 100 ? 72.04600 47.46600 -4.00900  1.000 21.32000 ? 144 ARG A O   1 
ATOM   740  C CB  . ARG A 1 100 ? 74.43700 49.70500 -3.69800  1.000 25.06000 ? 144 ARG A CB  1 
ATOM   741  C CG  . ARG A 1 100 ? 75.19100 50.66300 -4.59900  1.000 28.32000 ? 144 ARG A CG  1 
ATOM   742  C CD  . ARG A 1 100 ? 75.06700 50.24200 -6.05400  1.000 30.57000 ? 144 ARG A CD  1 
ATOM   743  N NE  . ARG A 1 100 ? 75.62300 51.23900 -6.96000  1.000 33.82000 ? 144 ARG A NE  1 
ATOM   744  C CZ  . ARG A 1 100 ? 75.50100 51.20200 -8.28000  1.000 31.51000 ? 144 ARG A CZ  1 
ATOM   745  N NH1 . ARG A 1 100 ? 74.85700 50.21800 -8.88600  1.000 31.65000 ? 144 ARG A NH1 1 
ATOM   746  N NH2 . ARG A 1 100 ? 76.03300 52.17900 -9.00800  1.000 30.90000 ? 144 ARG A NH2 1 
ATOM   747  N N   . GLN A 1 101 ? 72.07200 48.46300 -1.99300  1.000 23.30000 ? 145 GLN A N   1 
ATOM   748  C CA  . GLN A 1 101 ? 71.54400 47.28300 -1.32200  1.000 19.54000 ? 145 GLN A CA  1 
ATOM   749  C C   . GLN A 1 101 ? 70.06200 47.08100 -1.60400  1.000 17.90000 ? 145 GLN A C   1 
ATOM   750  O O   . GLN A 1 101 ? 69.57100 45.94900 -1.53100  1.000 19.84000 ? 145 GLN A O   1 
ATOM   751  C CB  . GLN A 1 101 ? 71.80500 47.38900 0.17800   1.000 20.81000 ? 145 GLN A CB  1 
ATOM   752  C CG  . GLN A 1 101 ? 73.26200 47.66800 0.49900   1.000 21.79000 ? 145 GLN A CG  1 
ATOM   753  C CD  . GLN A 1 101 ? 73.48400 47.99500 1.95300   1.000 23.40000 ? 145 GLN A CD  1 
ATOM   754  O OE1 . GLN A 1 101 ? 72.69800 47.60300 2.80800   1.000 22.79000 ? 145 GLN A OE1 1 
ATOM   755  N NE2 . GLN A 1 101 ? 74.55400 48.72500 2.24300   1.000 21.31000 ? 145 GLN A NE2 1 
ATOM   756  N N   . LEU A 1 102 ? 69.33700 48.15500 -1.92400  1.000 19.79000 ? 146 LEU A N   1 
ATOM   757  C CA  . LEU A 1 102 ? 67.97300 47.99900 -2.41800  1.000 19.04000 ? 146 LEU A CA  1 
ATOM   758  C C   . LEU A 1 102 ? 67.96000 47.25900 -3.74900  1.000 20.67000 ? 146 LEU A C   1 
ATOM   759  O O   . LEU A 1 102 ? 67.09700 46.40700 -3.98800  1.000 21.79000 ? 146 LEU A O   1 
ATOM   760  C CB  . LEU A 1 102 ? 67.30300 49.36600 -2.55600  1.000 20.73000 ? 146 LEU A CB  1 
ATOM   761  C CG  . LEU A 1 102 ? 66.68900 49.96600 -1.29200  1.000 18.74000 ? 146 LEU A CG  1 
ATOM   762  C CD1 . LEU A 1 102 ? 66.43800 51.45200 -1.47000  1.000 16.81000 ? 146 LEU A CD1 1 
ATOM   763  C CD2 . LEU A 1 102 ? 65.39600 49.24500 -0.95400  1.000 19.52000 ? 146 LEU A CD2 1 
ATOM   764  N N   . LEU A 1 103 ? 68.91600 47.56900 -4.62700  1.000 22.99000 ? 147 LEU A N   1 
ATOM   765  C CA  . LEU A 1 103 ? 69.02000 46.84800 -5.89200  1.000 22.94000 ? 147 LEU A CA  1 
ATOM   766  C C   . LEU A 1 103 ? 69.49600 45.41900 -5.67200  1.000 21.58000 ? 147 LEU A C   1 
ATOM   767  O O   . LEU A 1 103 ? 69.01600 44.49100 -6.33200  1.000 23.95000 ? 147 LEU A O   1 
ATOM   768  C CB  . LEU A 1 103 ? 69.96100 47.58700 -6.84200  1.000 21.88000 ? 147 LEU A CB  1 
ATOM   769  C CG  . LEU A 1 103 ? 69.56200 49.01100 -7.22800  1.000 22.64000 ? 147 LEU A CG  1 
ATOM   770  C CD1 . LEU A 1 103 ? 70.59100 49.60300 -8.17100  1.000 23.94000 ? 147 LEU A CD1 1 
ATOM   771  C CD2 . LEU A 1 103 ? 68.17700 49.03300 -7.85500  1.000 22.19000 ? 147 LEU A CD2 1 
ATOM   772  N N   . ALA A 1 104 ? 70.44000 45.22300 -4.74700  1.000 21.72000 ? 148 ALA A N   1 
ATOM   773  C CA  . ALA A 1 104 ? 70.89800 43.87500 -4.42700  1.000 21.41000 ? 148 ALA A CA  1 
ATOM   774  C C   . ALA A 1 104 ? 69.78100 43.03200 -3.83100  1.000 22.57000 ? 148 ALA A C   1 
ATOM   775  O O   . ALA A 1 104 ? 69.76400 41.80800 -4.00900  1.000 24.80000 ? 148 ALA A O   1 
ATOM   776  C CB  . ALA A 1 104 ? 72.08500 43.93700 -3.46600  1.000 22.21000 ? 148 ALA A CB  1 
ATOM   777  N N   . ALA A 1 105 ? 68.84500 43.66200 -3.11800  1.000 22.10000 ? 149 ALA A N   1 
ATOM   778  C CA  . ALA A 1 105 ? 67.69300 42.92900 -2.60600  1.000 20.62000 ? 149 ALA A CA  1 
ATOM   779  C C   . ALA A 1 105 ? 66.75400 42.52900 -3.73500  1.000 22.30000 ? 149 ALA A C   1 
ATOM   780  O O   . ALA A 1 105 ? 66.20700 41.42000 -3.73200  1.000 22.16000 ? 149 ALA A O   1 
ATOM   781  C CB  . ALA A 1 105 ? 66.95500 43.77000 -1.56600  1.000 21.66000 ? 149 ALA A CB  1 
ATOM   782  N N   . LEU A 1 106 ? 66.55200 43.42000 -4.70800  1.000 23.88000 ? 150 LEU A N   1 
ATOM   783  C CA  . LEU A 1 106 ? 65.70700 43.08800 -5.85000  1.000 23.78000 ? 150 LEU A CA  1 
ATOM   784  C C   . LEU A 1 106 ? 66.36300 42.03500 -6.73200  1.000 24.51000 ? 150 LEU A C   1 
ATOM   785  O O   . LEU A 1 106 ? 65.67800 41.17000 -7.29100  1.000 25.67000 ? 150 LEU A O   1 
ATOM   786  C CB  . LEU A 1 106 ? 65.39500 44.34900 -6.65400  1.000 20.96000 ? 150 LEU A CB  1 
ATOM   787  C CG  . LEU A 1 106 ? 64.55200 45.40300 -5.93600  1.000 19.82000 ? 150 LEU A CG  1 
ATOM   788  C CD1 . LEU A 1 106 ? 64.41200 46.64900 -6.79100  1.000 18.96000 ? 150 LEU A CD1 1 
ATOM   789  C CD2 . LEU A 1 106 ? 63.18800 44.84000 -5.58500  1.000 20.99000 ? 150 LEU A CD2 1 
ATOM   790  N N   . ASP A 1 107 ? 67.69000 42.08800 -6.86600  1.000 24.80000 ? 151 ASP A N   1 
ATOM   791  C CA  . ASP A 1 107 ? 68.39600 41.06800 -7.63200  1.000 25.37000 ? 151 ASP A CA  1 
ATOM   792  C C   . ASP A 1 107 ? 68.32100 39.70600 -6.95500  1.000 27.14000 ? 151 ASP A C   1 
ATOM   793  O O   . ASP A 1 107 ? 68.26500 38.68000 -7.64100  1.000 28.56000 ? 151 ASP A O   1 
ATOM   794  C CB  . ASP A 1 107 ? 69.85000 41.48600 -7.84500  1.000 27.17000 ? 151 ASP A CB  1 
ATOM   795  C CG  . ASP A 1 107 ? 69.97700 42.73300 -8.69900  1.000 28.24000 ? 151 ASP A CG  1 
ATOM   796  O OD1 . ASP A 1 107 ? 69.05900 42.99400 -9.50700  1.000 27.88000 ? 151 ASP A OD1 1 
ATOM   797  O OD2 . ASP A 1 107 ? 70.99100 43.45000 -8.56600  1.000 28.94000 ? 151 ASP A OD2 1 
ATOM   798  N N   . TYR A 1 108 ? 68.31600 39.67400 -5.61900  1.000 27.59000 ? 152 TYR A N   1 
ATOM   799  C CA  . TYR A 1 108 ? 68.11000 38.41300 -4.91400  1.000 26.05000 ? 152 TYR A CA  1 
ATOM   800  C C   . TYR A 1 108 ? 66.74200 37.82700 -5.23400  1.000 25.57000 ? 152 TYR A C   1 
ATOM   801  O O   . TYR A 1 108 ? 66.60400 36.61100 -5.41300  1.000 26.04000 ? 152 TYR A O   1 
ATOM   802  C CB  . TYR A 1 108 ? 68.26600 38.61900 -3.40400  1.000 25.48000 ? 152 TYR A CB  1 
ATOM   803  C CG  . TYR A 1 108 ? 67.86500 37.41700 -2.57300  1.000 24.54000 ? 152 TYR A CG  1 
ATOM   804  C CD1 . TYR A 1 108 ? 68.79100 36.43500 -2.24600  1.000 26.35000 ? 152 TYR A CD1 1 
ATOM   805  C CD2 . TYR A 1 108 ? 66.56200 37.26800 -2.11100  1.000 23.77000 ? 152 TYR A CD2 1 
ATOM   806  C CE1 . TYR A 1 108 ? 68.42900 35.33700 -1.48900  1.000 25.08000 ? 152 TYR A CE1 1 
ATOM   807  C CE2 . TYR A 1 108 ? 66.19100 36.17200 -1.35900  1.000 23.57000 ? 152 TYR A CE2 1 
ATOM   808  C CZ  . TYR A 1 108 ? 67.12900 35.21100 -1.04900  1.000 23.61000 ? 152 TYR A CZ  1 
ATOM   809  O OH  . TYR A 1 108 ? 66.76700 34.12000 -0.29700  1.000 28.97000 ? 152 TYR A OH  1 
ATOM   810  N N   . LEU A 1 109 ? 65.71600 38.67900 -5.30000  1.000 23.44000 ? 153 LEU A N   1 
ATOM   811  C CA  . LEU A 1 109 ? 64.37600 38.20600 -5.63000  1.000 26.51000 ? 153 LEU A CA  1 
ATOM   812  C C   . LEU A 1 109 ? 64.32500 37.62600 -7.03700  1.000 26.61000 ? 153 LEU A C   1 
ATOM   813  O O   . LEU A 1 109 ? 63.63500 36.63100 -7.28300  1.000 29.18000 ? 153 LEU A O   1 
ATOM   814  C CB  . LEU A 1 109 ? 63.37200 39.34900 -5.49200  1.000 25.29000 ? 153 LEU A CB  1 
ATOM   815  C CG  . LEU A 1 109 ? 63.10600 39.88100 -4.08600  1.000 24.95000 ? 153 LEU A CG  1 
ATOM   816  C CD1 . LEU A 1 109 ? 62.30500 41.16700 -4.15800  1.000 25.07000 ? 153 LEU A CD1 1 
ATOM   817  C CD2 . LEU A 1 109 ? 62.36800 38.84100 -3.26900  1.000 24.72000 ? 153 LEU A CD2 1 
ATOM   818  N N   . VAL A 1 110 ? 65.05400 38.23500 -7.97200  1.000 28.34000 ? 154 VAL A N   1 
ATOM   819  C CA  . VAL A 1 110 ? 64.98600 37.81100 -9.36600  1.000 27.77000 ? 154 VAL A CA  1 
ATOM   820  C C   . VAL A 1 110 ? 65.89500 36.61400 -9.62000  1.000 29.21000 ? 154 VAL A C   1 
ATOM   821  O O   . VAL A 1 110 ? 65.52600 35.68700 -10.35000 1.000 32.84000 ? 154 VAL A O   1 
ATOM   822  C CB  . VAL A 1 110 ? 65.33300 38.99300 -10.29100 1.000 27.31000 ? 154 VAL A CB  1 
ATOM   823  C CG1 . VAL A 1 110 ? 65.36700 38.54500 -11.74500 1.000 29.09000 ? 154 VAL A CG1 1 
ATOM   824  C CG2 . VAL A 1 110 ? 64.33700 40.12600 -10.10400 1.000 24.91000 ? 154 VAL A CG2 1 
ATOM   825  N N   . GLU A 1 111 ? 67.08000 36.59700 -9.01300  1.000 30.57000 ? 155 GLU A N   1 
ATOM   826  C CA  . GLU A 1 111 ? 68.11600 35.64600 -9.39600  1.000 30.62000 ? 155 GLU A CA  1 
ATOM   827  C C   . GLU A 1 111 ? 68.27800 34.47500 -8.43600  1.000 32.13000 ? 155 GLU A C   1 
ATOM   828  O O   . GLU A 1 111 ? 68.62500 33.37700 -8.88200  1.000 32.24000 ? 155 GLU A O   1 
ATOM   829  C CB  . GLU A 1 111 ? 69.46200 36.36600 -9.52800  1.000 31.02000 ? 155 GLU A CB  1 
ATOM   830  C CG  . GLU A 1 111 ? 69.46000 37.47500 -10.56600 1.000 31.56000 ? 155 GLU A CG  1 
ATOM   831  C CD  . GLU A 1 111 ? 70.72800 38.30100 -10.54400 1.000 37.38000 ? 155 GLU A CD  1 
ATOM   832  O OE1 . GLU A 1 111 ? 71.27400 38.52500 -9.44300  1.000 39.58000 ? 155 GLU A OE1 1 
ATOM   833  O OE2 . GLU A 1 111 ? 71.18300 38.72500 -11.62700 1.000 47.16000 ? 155 GLU A OE2 1 
ATOM   834  N N   . ARG A 1 112 ? 68.04700 34.66500 -7.13200  1.000 31.84000 ? 156 ARG A N   1 
ATOM   835  C CA  . ARG A 1 112 ? 68.43000 33.65700 -6.15000  1.000 30.21000 ? 156 ARG A CA  1 
ATOM   836  C C   . ARG A 1 112 ? 67.32900 33.35000 -5.13800  1.000 29.47000 ? 156 ARG A C   1 
ATOM   837  O O   . ARG A 1 112 ? 67.61300 32.74300 -4.09700  1.000 28.05000 ? 156 ARG A O   1 
ATOM   838  C CB  . ARG A 1 112 ? 69.70100 34.09000 -5.41100  1.000 28.99000 ? 156 ARG A CB  1 
ATOM   839  C CG  . ARG A 1 112 ? 70.87100 34.43400 -6.32200  1.000 30.88000 ? 156 ARG A CG  1 
ATOM   840  C CD  . ARG A 1 112 ? 72.00700 35.09500 -5.55200  1.000 34.63000 ? 156 ARG A CD  1 
ATOM   841  N NE  . ARG A 1 112 ? 72.57800 36.21500 -6.29300  1.000 37.27000 ? 156 ARG A NE  1 
ATOM   842  C CZ  . ARG A 1 112 ? 72.24000 37.48400 -6.10900  1.000 37.10000 ? 156 ARG A CZ  1 
ATOM   843  N NH1 . ARG A 1 112 ? 71.36800 37.84000 -5.18000  1.000 36.22000 ? 156 ARG A NH1 1 
ATOM   844  N NH2 . ARG A 1 112 ? 72.79200 38.42000 -6.87500  1.000 37.87000 ? 156 ARG A NH2 1 
ATOM   845  N N   . SER A 1 113 ? 66.08700 33.73800 -5.40700  1.000 30.26000 ? 157 SER A N   1 
ATOM   846  C CA  . SER A 1 113 ? 65.04300 33.56700 -4.41000  1.000 30.69000 ? 157 SER A CA  1 
ATOM   847  C C   . SER A 1 113 ? 64.49000 32.14400 -4.43900  1.000 34.96000 ? 157 SER A C   1 
ATOM   848  O O   . SER A 1 113 ? 64.73400 31.36300 -5.36300  1.000 34.71000 ? 157 SER A O   1 
ATOM   849  C CB  . SER A 1 113 ? 63.91900 34.57600 -4.62900  1.000 28.58000 ? 157 SER A CB  1 
ATOM   850  O OG  . SER A 1 113 ? 63.12100 34.22100 -5.74400  1.000 31.18000 ? 157 SER A OG  1 
ATOM   851  N N   . ASP A 1 114 ? 63.73700 31.81300 -3.39200  1.000 35.14000 ? 158 ASP A N   1 
ATOM   852  C CA  . ASP A 1 114 ? 63.08800 30.51600 -3.27500  1.000 34.98000 ? 158 ASP A CA  1 
ATOM   853  C C   . ASP A 1 114 ? 62.07000 30.32600 -4.39600  1.000 36.43000 ? 158 ASP A C   1 
ATOM   854  O O   . ASP A 1 114 ? 61.58300 31.28600 -4.99900  1.000 36.71000 ? 158 ASP A O   1 
ATOM   855  C CB  . ASP A 1 114 ? 62.40700 30.40000 -1.90800  1.000 34.70000 ? 158 ASP A CB  1 
ATOM   856  C CG  . ASP A 1 114 ? 61.89400 29.00100 -1.61700  1.000 38.56000 ? 158 ASP A CG  1 
ATOM   857  O OD1 . ASP A 1 114 ? 61.07100 28.47900 -2.39900  1.000 41.49000 ? 158 ASP A OD1 1 
ATOM   858  O OD2 . ASP A 1 114 ? 62.32000 28.41800 -0.59900  1.000 41.67000 ? 158 ASP A OD2 1 
ATOM   859  N N   . ARG A 1 115 ? 61.74100 29.06000 -4.67300  1.000 36.65000 ? 159 ARG A N   1 
ATOM   860  C CA  . ARG A 1 115 ? 60.74500 28.77400 -5.70100  1.000 37.38000 ? 159 ARG A CA  1 
ATOM   861  C C   . ARG A 1 115 ? 59.34200 29.19100 -5.27400  1.000 37.59000 ? 159 ARG A C   1 
ATOM   862  O O   . ARG A 1 115 ? 58.49600 29.44700 -6.13600  1.000 39.42000 ? 159 ARG A O   1 
ATOM   863  C CB  . ARG A 1 115 ? 60.76500 27.29000 -6.07100  1.000 39.21000 ? 159 ARG A CB  1 
ATOM   864  C CG  . ARG A 1 115 ? 59.77300 26.42800 -5.30300  1.000 43.53000 ? 159 ARG A CG  1 
ATOM   865  C CD  . ARG A 1 115 ? 59.21100 25.31900 -6.18000  1.000 42.96000 ? 159 ARG A CD  1 
ATOM   866  N NE  . ARG A 1 115 ? 58.35400 24.39900 -5.44100  1.000 44.16000 ? 159 ARG A NE  1 
ATOM   867  C CZ  . ARG A 1 115 ? 57.06000 24.59000 -5.22000  1.000 42.49000 ? 159 ARG A CZ  1 
ATOM   868  N NH1 . ARG A 1 115 ? 56.43900 25.67700 -5.64600  1.000 41.72000 ? 159 ARG A NH1 1 
ATOM   869  N NH2 . ARG A 1 115 ? 56.37300 23.66800 -4.55200  1.000 43.03000 ? 159 ARG A NH2 1 
ATOM   870  N N   . LYS A 1 116 ? 59.07500 29.27300 -3.96800  1.000 37.21000 ? 160 LYS A N   1 
ATOM   871  C CA  . LYS A 1 116 ? 57.80600 29.84000 -3.52300  1.000 34.58000 ? 160 LYS A CA  1 
ATOM   872  C C   . LYS A 1 116 ? 57.71800 31.31400 -3.88800  1.000 33.45000 ? 160 LYS A C   1 
ATOM   873  O O   . LYS A 1 116 ? 56.64600 31.80900 -4.25000  1.000 32.93000 ? 160 LYS A O   1 
ATOM   874  C CB  . LYS A 1 116 ? 57.63600 29.66400 -2.01500  1.000 35.57000 ? 160 LYS A CB  1 
ATOM   875  C CG  . LYS A 1 116 ? 57.89700 28.26200 -1.50700  1.000 37.43000 ? 160 LYS A CG  1 
ATOM   876  C CD  . LYS A 1 116 ? 57.45200 28.11300 -0.06100  1.000 39.39000 ? 160 LYS A CD  1 
ATOM   877  C CE  . LYS A 1 116 ? 58.09400 29.16000 0.83600   1.000 36.33000 ? 160 LYS A CE  1 
ATOM   878  N NZ  . LYS A 1 116 ? 59.55700 28.94100 1.01100   1.000 39.49000 ? 160 LYS A NZ  1 
ATOM   879  N N   . VAL A 1 117 ? 58.83900 32.02800 -3.79900  1.000 33.30000 ? 161 VAL A N   1 
ATOM   880  C CA  . VAL A 1 117 ? 58.85300 33.44900 -4.12400  1.000 32.17000 ? 161 VAL A CA  1 
ATOM   881  C C   . VAL A 1 117 ? 59.02800 33.65900 -5.62100  1.000 32.25000 ? 161 VAL A C   1 
ATOM   882  O O   . VAL A 1 117 ? 58.35200 34.50200 -6.22300  1.000 33.48000 ? 161 VAL A O   1 
ATOM   883  C CB  . VAL A 1 117 ? 59.95600 34.16000 -3.31800  1.000 32.60000 ? 161 VAL A CB  1 
ATOM   884  C CG1 . VAL A 1 117 ? 60.10600 35.60600 -3.76600  1.000 33.19000 ? 161 VAL A CG1 1 
ATOM   885  C CG2 . VAL A 1 117 ? 59.65100 34.08700 -1.83000  1.000 32.82000 ? 161 VAL A CG2 1 
ATOM   886  N N   . ARG A 1 118 ? 59.92200 32.89000 -6.24700  1.000 33.47000 ? 162 ARG A N   1 
ATOM   887  C CA  . ARG A 1 118 ? 60.24200 33.12000 -7.65200  1.000 32.93000 ? 162 ARG A CA  1 
ATOM   888  C C   . ARG A 1 118 ? 59.04100 32.85000 -8.55100  1.000 33.76000 ? 162 ARG A C   1 
ATOM   889  O O   . ARG A 1 118 ? 58.83200 33.55400 -9.54600  1.000 34.41000 ? 162 ARG A O   1 
ATOM   890  C CB  . ARG A 1 118 ? 61.43000 32.25200 -8.06600  1.000 34.61000 ? 162 ARG A CB  1 
ATOM   891  C CG  . ARG A 1 118 ? 62.15500 32.74700 -9.30300  1.000 32.27000 ? 162 ARG A CG  1 
ATOM   892  C CD  . ARG A 1 118 ? 63.33100 33.63200 -8.93200  1.000 32.15000 ? 162 ARG A CD  1 
ATOM   893  N NE  . ARG A 1 118 ? 64.42000 32.86400 -8.33800  1.000 33.75000 ? 162 ARG A NE  1 
ATOM   894  C CZ  . ARG A 1 118 ? 65.46900 32.40900 -9.01000  1.000 35.10000 ? 162 ARG A CZ  1 
ATOM   895  N NH1 . ARG A 1 118 ? 65.61000 32.63500 -10.30600 1.000 36.03000 ? 162 ARG A NH1 1 
ATOM   896  N NH2 . ARG A 1 118 ? 66.40200 31.71500 -8.36400  1.000 32.20000 ? 162 ARG A NH2 1 
ATOM   897  N N   . GLU A 1 119 ? 58.23600 31.83800 -8.21500  1.000 33.87000 ? 163 GLU A N   1 
ATOM   898  C CA  . GLU A 1 119 ? 57.07300 31.51200 -9.03600  1.000 33.58000 ? 163 GLU A CA  1 
ATOM   899  C C   . GLU A 1 119 ? 56.02000 32.61200 -9.00900  1.000 32.90000 ? 163 GLU A C   1 
ATOM   900  O O   . GLU A 1 119 ? 55.22900 32.72800 -9.95100  1.000 36.03000 ? 163 GLU A O   1 
ATOM   901  C CB  . GLU A 1 119 ? 56.45700 30.19200 -8.57800  1.000 36.32000 ? 163 GLU A CB  1 
ATOM   902  C CG  . GLU A 1 119 ? 57.18600 28.96300 -9.08200  1.000 41.40000 ? 163 GLU A CG  1 
ATOM   903  C CD  . GLU A 1 119 ? 56.53900 27.67700 -8.61600  1.000 47.57000 ? 163 GLU A CD  1 
ATOM   904  O OE1 . GLU A 1 119 ? 55.91600 27.68300 -7.53300  1.000 48.78000 ? 163 GLU A OE1 1 
ATOM   905  O OE2 . GLU A 1 119 ? 56.64900 26.66200 -9.33500  1.000 47.01000 ? 163 GLU A OE2 1 
ATOM   906  N N   . ARG A 1 120 ? 55.98500 33.42000 -7.95100  1.000 32.49000 ? 164 ARG A N   1 
ATOM   907  C CA  . ARG A 1 120 ? 54.98900 34.47400 -7.80700  1.000 29.52000 ? 164 ARG A CA  1 
ATOM   908  C C   . ARG A 1 120 ? 55.49900 35.84200 -8.23600  1.000 28.20000 ? 164 ARG A C   1 
ATOM   909  O O   . ARG A 1 120 ? 54.76700 36.82900 -8.10800  1.000 28.52000 ? 164 ARG A O   1 
ATOM   910  C CB  . ARG A 1 120 ? 54.50600 34.54800 -6.35500  1.000 30.01000 ? 164 ARG A CB  1 
ATOM   911  C CG  . ARG A 1 120 ? 53.76100 33.31700 -5.87200  1.000 31.11000 ? 164 ARG A CG  1 
ATOM   912  C CD  . ARG A 1 120 ? 53.55400 33.36900 -4.36900  1.000 30.02000 ? 164 ARG A CD  1 
ATOM   913  N NE  . ARG A 1 120 ? 52.55500 32.41100 -3.91200  1.000 29.85000 ? 164 ARG A NE  1 
ATOM   914  C CZ  . ARG A 1 120 ? 52.82100 31.16600 -3.54300  1.000 28.28000 ? 164 ARG A CZ  1 
ATOM   915  N NH1 . ARG A 1 120 ? 54.05200 30.68200 -3.57700  1.000 29.91000 ? 164 ARG A NH1 1 
ATOM   916  N NH2 . ARG A 1 120 ? 51.82700 30.38700 -3.12600  1.000 29.76000 ? 164 ARG A NH2 1 
ATOM   917  N N   . LEU A 1 121 ? 56.72400 35.92800 -8.74300  1.000 28.39000 ? 165 LEU A N   1 
ATOM   918  C CA  . LEU A 1 121 ? 57.37800 37.20100 -9.01300  1.000 27.22000 ? 165 LEU A CA  1 
ATOM   919  C C   . LEU A 1 121 ? 57.42300 37.47600 -10.50900 1.000 28.77000 ? 165 LEU A C   1 
ATOM   920  O O   . LEU A 1 121 ? 57.85200 36.62100 -11.29100 1.000 28.96000 ? 165 LEU A O   1 
ATOM   921  C CB  . LEU A 1 121 ? 58.79700 37.21200 -8.44100  1.000 26.39000 ? 165 LEU A CB  1 
ATOM   922  C CG  . LEU A 1 121 ? 59.62100 38.46300 -8.74300  1.000 24.76000 ? 165 LEU A CG  1 
ATOM   923  C CD1 . LEU A 1 121 ? 58.92900 39.69600 -8.19700  1.000 25.14000 ? 165 LEU A CD1 1 
ATOM   924  C CD2 . LEU A 1 121 ? 61.01300 38.33000 -8.16400  1.000 27.73000 ? 165 LEU A CD2 1 
ATOM   925  N N   . ASP A 1 122 ? 56.98200 38.67200 -10.89800 1.000 26.61000 ? 166 ASP A N   1 
ATOM   926  C CA  . ASP A 1 122 ? 57.20500 39.19800 -12.23700 1.000 26.49000 ? 166 ASP A CA  1 
ATOM   927  C C   . ASP A 1 122 ? 58.48700 40.02200 -12.20200 1.000 24.10000 ? 166 ASP A C   1 
ATOM   928  O O   . ASP A 1 122 ? 58.47700 41.16300 -11.72500 1.000 25.12000 ? 166 ASP A O   1 
ATOM   929  C CB  . ASP A 1 122 ? 56.01700 40.04500 -12.70000 1.000 26.49000 ? 166 ASP A CB  1 
ATOM   930  C CG  . ASP A 1 122 ? 56.06700 40.37300 -14.18400 1.000 24.69000 ? 166 ASP A CG  1 
ATOM   931  O OD1 . ASP A 1 122 ? 57.16200 40.32000 -14.78300 1.000 23.74000 ? 166 ASP A OD1 1 
ATOM   932  O OD2 . ASP A 1 122 ? 55.00200 40.69000 -14.75200 1.000 25.81000 ? 166 ASP A OD2 1 
ATOM   933  N N   . PRO A 1 123 ? 59.60600 39.48400 -12.69800 1.000 23.70000 ? 167 PRO A N   1 
ATOM   934  C CA  . PRO A 1 123 ? 60.89800 40.16800 -12.52300 1.000 22.97000 ? 167 PRO A CA  1 
ATOM   935  C C   . PRO A 1 123 ? 61.03700 41.45900 -13.31300 1.000 23.39000 ? 167 PRO A C   1 
ATOM   936  O O   . PRO A 1 123 ? 62.04000 42.16200 -13.13200 1.000 23.66000 ? 167 PRO A O   1 
ATOM   937  C CB  . PRO A 1 123 ? 61.91300 39.12100 -12.99900 1.000 25.05000 ? 167 PRO A CB  1 
ATOM   938  C CG  . PRO A 1 123 ? 61.15000 38.27700 -13.96300 1.000 25.69000 ? 167 PRO A CG  1 
ATOM   939  C CD  . PRO A 1 123 ? 59.74100 38.21900 -13.44200 1.000 26.20000 ? 167 PRO A CD  1 
ATOM   940  N N   . ASN A 1 124 ? 60.07800 41.79900 -14.17200 1.000 26.65000 ? 168 ASN A N   1 
ATOM   941  C CA  . ASN A 1 124 ? 60.15800 43.01800 -14.96300 1.000 25.15000 ? 168 ASN A CA  1 
ATOM   942  C C   . ASN A 1 124 ? 59.50000 44.21300 -14.28800 1.000 25.59000 ? 168 ASN A C   1 
ATOM   943  O O   . ASN A 1 124 ? 59.66100 45.34000 -14.76900 1.000 27.42000 ? 168 ASN A O   1 
ATOM   944  C CB  . ASN A 1 124 ? 59.51900 42.80100 -16.33900 1.000 26.71000 ? 168 ASN A CB  1 
ATOM   945  C CG  . ASN A 1 124 ? 60.13400 41.63900 -17.09000 1.000 26.17000 ? 168 ASN A CG  1 
ATOM   946  O OD1 . ASN A 1 124 ? 61.24900 41.73600 -17.60200 1.000 29.86000 ? 168 ASN A OD1 1 
ATOM   947  N ND2 . ASN A 1 124 ? 59.40700 40.53100 -17.16500 1.000 25.84000 ? 168 ASN A ND2 1 
ATOM   948  N N   . ARG A 1 125 ? 58.77400 44.00300 -13.19200 1.000 26.93000 ? 169 ARG A N   1 
ATOM   949  C CA  . ARG A 1 125 ? 58.03500 45.06000 -12.50400 1.000 25.96000 ? 169 ARG A CA  1 
ATOM   950  C C   . ARG A 1 125 ? 58.51600 45.13200 -11.05400 1.000 23.73000 ? 169 ARG A C   1 
ATOM   951  O O   . ARG A 1 125 ? 58.00400 44.42700 -10.18200 1.000 21.85000 ? 169 ARG A O   1 
ATOM   952  C CB  . ARG A 1 125 ? 56.53200 44.80100 -12.60000 1.000 24.20000 ? 169 ARG A CB  1 
ATOM   953  C CG  . ARG A 1 125 ? 56.05900 44.61600 -14.03300 1.000 24.11000 ? 169 ARG A CG  1 
ATOM   954  C CD  . ARG A 1 125 ? 54.55000 44.53900 -14.15200 1.000 24.96000 ? 169 ARG A CD  1 
ATOM   955  N NE  . ARG A 1 125 ? 54.01100 43.27500 -13.66600 1.000 26.09000 ? 169 ARG A NE  1 
ATOM   956  C CZ  . ARG A 1 125 ? 53.27500 43.14500 -12.57100 1.000 24.62000 ? 169 ARG A CZ  1 
ATOM   957  N NH1 . ARG A 1 125 ? 52.97400 44.18600 -11.81300 1.000 25.80000 ? 169 ARG A NH1 1 
ATOM   958  N NH2 . ARG A 1 125 ? 52.82000 41.94100 -12.23400 1.000 26.30000 ? 169 ARG A NH2 1 
ATOM   959  N N   . LEU A 1 126 ? 59.49800 46.00000 -10.80400 1.000 24.73000 ? 170 LEU A N   1 
ATOM   960  C CA  . LEU A 1 126 ? 60.12200 46.14100 -9.49500  1.000 21.89000 ? 170 LEU A CA  1 
ATOM   961  C C   . LEU A 1 126 ? 60.07800 47.59700 -9.05000  1.000 22.58000 ? 170 LEU A C   1 
ATOM   962  O O   . LEU A 1 126 ? 60.05300 48.51600 -9.87400  1.000 23.31000 ? 170 LEU A O   1 
ATOM   963  C CB  . LEU A 1 126 ? 61.57900 45.65200 -9.51600  1.000 22.20000 ? 170 LEU A CB  1 
ATOM   964  C CG  . LEU A 1 126 ? 61.82500 44.25800 -10.09900 1.000 21.62000 ? 170 LEU A CG  1 
ATOM   965  C CD1 . LEU A 1 126 ? 63.31300 43.94200 -10.16300 1.000 20.65000 ? 170 LEU A CD1 1 
ATOM   966  C CD2 . LEU A 1 126 ? 61.08700 43.20700 -9.29200  1.000 22.02000 ? 170 LEU A CD2 1 
ATOM   967  N N   . ALA A 1 127 ? 60.08200 47.80000 -7.73200  1.000 22.99000 ? 171 ALA A N   1 
ATOM   968  C CA  . ALA A 1 127 ? 60.00700 49.13300 -7.15100  1.000 20.06000 ? 171 ALA A CA  1 
ATOM   969  C C   . ALA A 1 127 ? 60.86400 49.18900 -5.89300  1.000 20.22000 ? 171 ALA A C   1 
ATOM   970  O O   . ALA A 1 127 ? 61.33000 48.16700 -5.38300  1.000 20.07000 ? 171 ALA A O   1 
ATOM   971  C CB  . ALA A 1 127 ? 58.55900 49.52700 -6.83400  1.000 20.11000 ? 171 ALA A CB  1 
ATOM   972  N N   . VAL A 1 128 ? 61.07300 50.40700 -5.39600  1.000 21.28000 ? 172 VAL A N   1 
ATOM   973  C CA  . VAL A 1 128 ? 61.86100 50.64200 -4.19300  1.000 20.35000 ? 172 VAL A CA  1 
ATOM   974  C C   . VAL A 1 128 ? 61.12600 51.63400 -3.30300  1.000 18.91000 ? 172 VAL A C   1 
ATOM   975  O O   . VAL A 1 128 ? 60.38000 52.49600 -3.77600  1.000 19.84000 ? 172 VAL A O   1 
ATOM   976  C CB  . VAL A 1 128 ? 63.28200 51.15700 -4.51400  1.000 19.87000 ? 172 VAL A CB  1 
ATOM   977  C CG1 . VAL A 1 128 ? 64.13600 50.04300 -5.09900  1.000 18.95000 ? 172 VAL A CG1 1 
ATOM   978  C CG2 . VAL A 1 128 ? 63.21800 52.34900 -5.45800  1.000 20.89000 ? 172 VAL A CG2 1 
ATOM   979  N N   . MET A 1 129 ? 61.34000 51.49700 -1.99700  1.000 22.01000 ? 173 MET A N   1 
ATOM   980  C CA  . MET A 1 129 ? 60.77100 52.39700 -1.00600  1.000 19.09000 ? 173 MET A CA  1 
ATOM   981  C C   . MET A 1 129 ? 61.74500 52.46400 0.15900   1.000 18.74000 ? 173 MET A C   1 
ATOM   982  O O   . MET A 1 129 ? 62.40700 51.47300 0.47100   1.000 19.22000 ? 173 MET A O   1 
ATOM   983  C CB  . MET A 1 129 ? 59.38700 51.92200 -0.54300  1.000 17.94000 ? 173 MET A CB  1 
ATOM   984  C CG  . MET A 1 129 ? 58.70000 52.84600 0.45600   1.000 17.20000 ? 173 MET A CG  1 
ATOM   985  S SD  . MET A 1 129 ? 56.94100 52.50200 0.66700   1.000 20.25000 ? 173 MET A SD  1 
ATOM   986  C CE  . MET A 1 129 ? 56.97500 50.77100 1.11100   1.000 15.98000 ? 173 MET A CE  1 
ATOM   987  N N   . GLY A 1 130 ? 61.85100 53.63000 0.78500   1.000 19.16000 ? 174 GLY A N   1 
ATOM   988  C CA  . GLY A 1 130 ? 62.80700 53.79000 1.86300   1.000 19.36000 ? 174 GLY A CA  1 
ATOM   989  C C   . GLY A 1 130 ? 62.42700 54.91800 2.78800   1.000 19.83000 ? 174 GLY A C   1 
ATOM   990  O O   . GLY A 1 130 ? 61.75900 55.87500 2.38800   1.000 17.48000 ? 174 GLY A O   1 
ATOM   991  N N   . HIS A 1 131 ? 62.87200 54.80800 4.03600   1.000 21.41000 ? 175 HIS A N   1 
ATOM   992  C CA  . HIS A 1 131 ? 62.61800 55.81100 5.05800   1.000 19.97000 ? 175 HIS A CA  1 
ATOM   993  C C   . HIS A 1 131 ? 63.88500 56.61300 5.32000   1.000 17.07000 ? 175 HIS A C   1 
ATOM   994  O O   . HIS A 1 131 ? 64.94300 56.03600 5.59500   1.000 18.88000 ? 175 HIS A O   1 
ATOM   995  C CB  . HIS A 1 131 ? 62.12300 55.15700 6.34900   1.000 19.02000 ? 175 HIS A CB  1 
ATOM   996  C CG  . HIS A 1 131 ? 61.99700 56.10700 7.49900   1.000 20.24000 ? 175 HIS A CG  1 
ATOM   997  N ND1 . HIS A 1 131 ? 62.66400 55.92200 8.69000   1.000 19.74000 ? 175 HIS A ND1 1 
ATOM   998  C CD2 . HIS A 1 131 ? 61.28200 57.24800 7.64100   1.000 20.82000 ? 175 HIS A CD2 1 
ATOM   999  C CE1 . HIS A 1 131 ? 62.36600 56.90800 9.51700   1.000 19.34000 ? 175 HIS A CE1 1 
ATOM   1000 N NE2 . HIS A 1 131 ? 61.52900 57.72600 8.90500   1.000 18.75000 ? 175 HIS A NE2 1 
ATOM   1001 N N   . ALA A 1 132 ? 63.76600 57.93900 5.22000   1.000 16.92000 ? 176 ALA A N   1 
ATOM   1002 C CA  . ALA A 1 132 ? 64.83000 58.88300 5.54200   1.000 19.55000 ? 176 ALA A CA  1 
ATOM   1003 C C   . ALA A 1 132 ? 66.09000 58.60000 4.72600   1.000 20.02000 ? 176 ALA A C   1 
ATOM   1004 O O   . ALA A 1 132 ? 66.08800 58.81500 3.51100   1.000 22.37000 ? 176 ALA A O   1 
ATOM   1005 C CB  . ALA A 1 132 ? 65.10300 58.86500 7.04500   1.000 20.87000 ? 176 ALA A CB  1 
ATOM   1006 N N   . MET A 1 133 ? 67.16900 58.12900 5.36300   1.000 19.49000 ? 177 MET A N   1 
ATOM   1007 C CA  . MET A 1 133 ? 68.35900 57.76100 4.59400   1.000 19.49000 ? 177 MET A CA  1 
ATOM   1008 C C   . MET A 1 133 ? 68.06500 56.63000 3.62300   1.000 20.88000 ? 177 MET A C   1 
ATOM   1009 O O   . MET A 1 133 ? 68.68300 56.55100 2.55500   1.000 19.71000 ? 177 MET A O   1 
ATOM   1010 C CB  . MET A 1 133 ? 69.50700 57.34900 5.51300   1.000 17.76000 ? 177 MET A CB  1 
ATOM   1011 C CG  . MET A 1 133 ? 70.34900 58.49600 6.01200   1.000 18.40000 ? 177 MET A CG  1 
ATOM   1012 S SD  . MET A 1 133 ? 71.98700 57.97100 6.54700   1.000 24.28000 ? 177 MET A SD  1 
ATOM   1013 C CE  . MET A 1 133 ? 72.60900 59.50800 7.21300   1.000 21.67000 ? 177 MET A CE  1 
ATOM   1014 N N   . GLY A 1 134 ? 67.15400 55.72900 3.99200   1.000 19.34000 ? 178 GLY A N   1 
ATOM   1015 C CA  . GLY A 1 134 ? 66.64300 54.77300 3.02900   1.000 19.59000 ? 178 GLY A CA  1 
ATOM   1016 C C   . GLY A 1 134 ? 65.83300 55.43300 1.93300   1.000 21.07000 ? 178 GLY A C   1 
ATOM   1017 O O   . GLY A 1 134 ? 65.76400 54.91500 0.81400   1.000 19.96000 ? 178 GLY A O   1 
ATOM   1018 N N   . GLY A 1 135 ? 65.19700 56.56800 2.24200   1.000 21.90000 ? 179 GLY A N   1 
ATOM   1019 C CA  . GLY A 1 135 ? 64.50100 57.32900 1.21600   1.000 20.77000 ? 179 GLY A CA  1 
ATOM   1020 C C   . GLY A 1 135 ? 65.46600 58.01100 0.27000   1.000 21.24000 ? 179 GLY A C   1 
ATOM   1021 O O   . GLY A 1 135 ? 65.19300 58.13700 -0.92700  1.000 20.61000 ? 179 GLY A O   1 
ATOM   1022 N N   . GLY A 1 136 ? 66.61300 58.44700 0.79200   1.000 22.04000 ? 180 GLY A N   1 
ATOM   1023 C CA  . GLY A 1 136 ? 67.68000 58.91600 -0.07400  1.000 20.10000 ? 180 GLY A CA  1 
ATOM   1024 C C   . GLY A 1 136 ? 68.24800 57.80400 -0.93300  1.000 22.49000 ? 180 GLY A C   1 
ATOM   1025 O O   . GLY A 1 136 ? 68.58800 58.02000 -2.09900  1.000 22.31000 ? 180 GLY A O   1 
ATOM   1026 N N   . GLY A 1 137 ? 68.34600 56.59600 -0.37500  1.000 20.45000 ? 181 GLY A N   1 
ATOM   1027 C CA  . GLY A 1 137 ? 68.75600 55.45300 -1.17000  1.000 20.58000 ? 181 GLY A CA  1 
ATOM   1028 C C   . GLY A 1 137 ? 67.71700 55.04600 -2.19300  1.000 22.27000 ? 181 GLY A C   1 
ATOM   1029 O O   . GLY A 1 137 ? 68.05600 54.47200 -3.23200  1.000 23.43000 ? 181 GLY A O   1 
ATOM   1030 N N   . SER A 1 138 ? 66.44200 55.33100 -1.91800  1.000 21.37000 ? 182 SER A N   1 
ATOM   1031 C CA  . SER A 1 138 ? 65.39800 55.08400 -2.90700  1.000 22.05000 ? 182 SER A CA  1 
ATOM   1032 C C   . SER A 1 138 ? 65.58800 55.97200 -4.13000  1.000 24.33000 ? 182 SER A C   1 
ATOM   1033 O O   . SER A 1 138 ? 65.44500 55.51200 -5.26900  1.000 22.21000 ? 182 SER A O   1 
ATOM   1034 C CB  . SER A 1 138 ? 64.02200 55.30700 -2.27900  1.000 20.00000 ? 182 SER A CB  1 
ATOM   1035 O OG  . SER A 1 138 ? 62.98500 54.99000 -3.18900  1.000 22.32000 ? 182 SER A OG  1 
ATOM   1036 N N   . LEU A 1 139 ? 65.91400 57.24900 -3.91100  1.000 24.66000 ? 183 LEU A N   1 
ATOM   1037 C CA  . LEU A 1 139 ? 66.27200 58.12700 -5.02100  1.000 21.74000 ? 183 LEU A CA  1 
ATOM   1038 C C   . LEU A 1 139 ? 67.55300 57.65900 -5.69800  1.000 24.15000 ? 183 LEU A C   1 
ATOM   1039 O O   . LEU A 1 139 ? 67.68000 57.73600 -6.92500  1.000 24.28000 ? 183 LEU A O   1 
ATOM   1040 C CB  . LEU A 1 139 ? 66.42800 59.56300 -4.52100  1.000 19.23000 ? 183 LEU A CB  1 
ATOM   1041 C CG  . LEU A 1 139 ? 65.17200 60.26900 -4.01100  1.000 21.14000 ? 183 LEU A CG  1 
ATOM   1042 C CD1 . LEU A 1 139 ? 65.54600 61.48800 -3.18400  1.000 18.66000 ? 183 LEU A CD1 1 
ATOM   1043 C CD2 . LEU A 1 139 ? 64.27600 60.67000 -5.17200  1.000 21.77000 ? 183 LEU A CD2 1 
ATOM   1044 N N   . GLU A 1 140 ? 68.51800 57.17800 -4.90900  1.000 23.69000 ? 184 GLU A N   1 
ATOM   1045 C CA  . GLU A 1 140 ? 69.76300 56.67500 -5.47900  1.000 23.89000 ? 184 GLU A CA  1 
ATOM   1046 C C   . GLU A 1 140 ? 69.51600 55.44900 -6.34800  1.000 23.98000 ? 184 GLU A C   1 
ATOM   1047 O O   . GLU A 1 140 ? 70.13400 55.29500 -7.40800  1.000 25.67000 ? 184 GLU A O   1 
ATOM   1048 C CB  . GLU A 1 140 ? 70.75400 56.34200 -4.36400  1.000 22.34000 ? 184 GLU A CB  1 
ATOM   1049 C CG  . GLU A 1 140 ? 71.29300 57.54900 -3.62100  1.000 21.53000 ? 184 GLU A CG  1 
ATOM   1050 C CD  . GLU A 1 140 ? 72.58800 58.06500 -4.20800  1.000 22.22000 ? 184 GLU A CD  1 
ATOM   1051 O OE1 . GLU A 1 140 ? 73.07900 57.46800 -5.18900  1.000 26.39000 ? 184 GLU A OE1 1 
ATOM   1052 O OE2 . GLU A 1 140 ? 73.12100 59.06600 -3.68500  1.000 23.39000 ? 184 GLU A OE2 1 
ATOM   1053 N N   . ALA A 1 141 ? 68.61100 54.56700 -5.91800  1.000 23.99000 ? 185 ALA A N   1 
ATOM   1054 C CA  . ALA A 1 141 ? 68.37900 53.32600 -6.64700  1.000 23.69000 ? 185 ALA A CA  1 
ATOM   1055 C C   . ALA A 1 141 ? 67.76400 53.57700 -8.01800  1.000 23.25000 ? 185 ALA A C   1 
ATOM   1056 O O   . ALA A 1 141 ? 67.99100 52.79300 -8.94600  1.000 24.96000 ? 185 ALA A O   1 
ATOM   1057 C CB  . ALA A 1 141 ? 67.48900 52.39300 -5.82600  1.000 20.61000 ? 185 ALA A CB  1 
ATOM   1058 N N   . THR A 1 142 ? 66.98800 54.65300 -8.16900  1.000 24.05000 ? 186 THR A N   1 
ATOM   1059 C CA  . THR A 1 142 ? 66.38400 54.95300 -9.46200  1.000 24.00000 ? 186 THR A CA  1 
ATOM   1060 C C   . THR A 1 142 ? 67.39100 55.53700 -10.44200 1.000 24.23000 ? 186 THR A C   1 
ATOM   1061 O O   . THR A 1 142 ? 67.28300 55.30100 -11.65000 1.000 26.98000 ? 186 THR A O   1 
ATOM   1062 C CB  . THR A 1 142 ? 65.20700 55.91400 -9.29400  1.000 21.73000 ? 186 THR A CB  1 
ATOM   1063 O OG1 . THR A 1 142 ? 65.65300 57.12200 -8.66500  1.000 23.08000 ? 186 THR A OG1 1 
ATOM   1064 C CG2 . THR A 1 142 ? 64.12900 55.27500 -8.44700  1.000 22.35000 ? 186 THR A CG2 1 
ATOM   1065 N N   . VAL A 1 143 ? 68.36500 56.30300 -9.94900  1.000 23.27000 ? 187 VAL A N   1 
ATOM   1066 C CA  . VAL A 1 143 ? 69.44100 56.77200 -10.81400 1.000 22.95000 ? 187 VAL A CA  1 
ATOM   1067 C C   . VAL A 1 143 ? 70.35500 55.61300 -11.19200 1.000 25.73000 ? 187 VAL A C   1 
ATOM   1068 O O   . VAL A 1 143 ? 70.86600 55.54700 -12.31700 1.000 27.90000 ? 187 VAL A O   1 
ATOM   1069 C CB  . VAL A 1 143 ? 70.21400 57.91400 -10.12800 1.000 22.59000 ? 187 VAL A CB  1 
ATOM   1070 C CG1 . VAL A 1 143 ? 71.33600 58.41800 -11.02400 1.000 24.17000 ? 187 VAL A CG1 1 
ATOM   1071 C CG2 . VAL A 1 143 ? 69.26800 59.04800 -9.76300  1.000 21.76000 ? 187 VAL A CG2 1 
ATOM   1072 N N   . MET A 1 144 ? 70.56500 54.67500 -10.26600 1.000 26.80000 ? 188 MET A N   1 
ATOM   1073 C CA  . MET A 1 144 ? 71.39300 53.51100 -10.56400 1.000 25.38000 ? 188 MET A CA  1 
ATOM   1074 C C   . MET A 1 144 ? 70.66900 52.52000 -11.46500 1.000 23.14000 ? 188 MET A C   1 
ATOM   1075 O O   . MET A 1 144 ? 71.31500 51.78500 -12.22000 1.000 24.18000 ? 188 MET A O   1 
ATOM   1076 C CB  . MET A 1 144 ? 71.82300 52.82300 -9.26900  1.000 26.25000 ? 188 MET A CB  1 
ATOM   1077 C CG  . MET A 1 144 ? 72.69600 53.67200 -8.36100  1.000 27.61000 ? 188 MET A CG  1 
ATOM   1078 S SD  . MET A 1 144 ? 72.84800 52.97000 -6.70700  1.000 28.58000 ? 188 MET A SD  1 
ATOM   1079 C CE  . MET A 1 144 ? 73.95600 54.14900 -5.93900  1.000 25.09000 ? 188 MET A CE  1 
ATOM   1080 N N   . ARG A 1 145 ? 69.34000 52.47800 -11.39900 1.000 23.24000 ? 189 ARG A N   1 
ATOM   1081 C CA  . ARG A 1 145 ? 68.54900 51.54800 -12.20100 1.000 25.16000 ? 189 ARG A CA  1 
ATOM   1082 C C   . ARG A 1 145 ? 67.29000 52.25000 -12.68400 1.000 26.41000 ? 189 ARG A C   1 
ATOM   1083 O O   . ARG A 1 145 ? 66.24100 52.20000 -12.02900 1.000 25.21000 ? 189 ARG A O   1 
ATOM   1084 C CB  . ARG A 1 145 ? 68.20300 50.28700 -11.40900 1.000 25.08000 ? 189 ARG A CB  1 
ATOM   1085 C CG  . ARG A 1 145 ? 67.48500 49.23700 -12.22800 1.000 26.42000 ? 189 ARG A CG  1 
ATOM   1086 C CD  . ARG A 1 145 ? 67.50400 47.89400 -11.53500 1.000 28.55000 ? 189 ARG A CD  1 
ATOM   1087 N NE  . ARG A 1 145 ? 68.86200 47.44900 -11.25100 1.000 25.06000 ? 189 ARG A NE  1 
ATOM   1088 C CZ  . ARG A 1 145 ? 69.16700 46.25800 -10.75500 1.000 25.13000 ? 189 ARG A CZ  1 
ATOM   1089 N NH1 . ARG A 1 145 ? 68.23200 45.35900 -10.49300 1.000 27.01000 ? 189 ARG A NH1 1 
ATOM   1090 N NH2 . ARG A 1 145 ? 70.44100 45.96100 -10.51600 1.000 26.34000 ? 189 ARG A NH2 1 
ATOM   1091 N N   . PRO A 1 146 ? 67.35500 52.91800 -13.84000 1.000 25.80000 ? 190 PRO A N   1 
ATOM   1092 C CA  . PRO A 1 146 ? 66.17200 53.63300 -14.34500 1.000 22.91000 ? 190 PRO A CA  1 
ATOM   1093 C C   . PRO A 1 146 ? 65.06100 52.72100 -14.83800 1.000 20.91000 ? 190 PRO A C   1 
ATOM   1094 O O   . PRO A 1 146 ? 63.97800 53.22400 -15.16200 1.000 22.47000 ? 190 PRO A O   1 
ATOM   1095 C CB  . PRO A 1 146 ? 66.73900 54.48600 -15.48600 1.000 25.66000 ? 190 PRO A CB  1 
ATOM   1096 C CG  . PRO A 1 146 ? 67.95800 53.75400 -15.93100 1.000 26.36000 ? 190 PRO A CG  1 
ATOM   1097 C CD  . PRO A 1 146 ? 68.53600 53.12600 -14.69500 1.000 24.75000 ? 190 PRO A CD  1 
ATOM   1098 N N   . SER A 1 147 ? 65.28400 51.40900 -14.90400 1.000 22.80000 ? 191 SER A N   1 
ATOM   1099 C CA  . SER A 1 147 ? 64.24400 50.47400 -15.31300 1.000 22.32000 ? 191 SER A CA  1 
ATOM   1100 C C   . SER A 1 147 ? 63.25900 50.15400 -14.19600 1.000 24.32000 ? 191 SER A C   1 
ATOM   1101 O O   . SER A 1 147 ? 62.31700 49.38800 -14.42500 1.000 26.17000 ? 191 SER A O   1 
ATOM   1102 C CB  . SER A 1 147 ? 64.87100 49.17800 -15.83900 1.000 24.90000 ? 191 SER A CB  1 
ATOM   1103 O OG  . SER A 1 147 ? 65.73800 48.59400 -14.88300 1.000 28.41000 ? 191 SER A OG  1 
ATOM   1104 N N   . LEU A 1 148 ? 63.44600 50.71400 -13.00300 1.000 23.96000 ? 192 LEU A N   1 
ATOM   1105 C CA  . LEU A 1 148 ? 62.49100 50.51500 -11.92400 1.000 22.60000 ? 192 LEU A CA  1 
ATOM   1106 C C   . LEU A 1 148 ? 61.15700 51.17000 -12.26300 1.000 21.51000 ? 192 LEU A C   1 
ATOM   1107 O O   . LEU A 1 148 ? 61.09600 52.17200 -12.98100 1.000 24.98000 ? 192 LEU A O   1 
ATOM   1108 C CB  . LEU A 1 148 ? 63.03500 51.08300 -10.61500 1.000 22.68000 ? 192 LEU A CB  1 
ATOM   1109 C CG  . LEU A 1 148 ? 64.25500 50.37300 -10.02900 1.000 23.58000 ? 192 LEU A CG  1 
ATOM   1110 C CD1 . LEU A 1 148 ? 64.82600 51.17100 -8.87000  1.000 23.02000 ? 192 LEU A CD1 1 
ATOM   1111 C CD2 . LEU A 1 148 ? 63.88800 48.96600 -9.58900  1.000 20.66000 ? 192 LEU A CD2 1 
ATOM   1112 N N   . LYS A 1 149 ? 60.07900 50.59600 -11.73200 1.000 21.42000 ? 193 LYS A N   1 
ATOM   1113 C CA  . LYS A 1 149 ? 58.73800 51.06000 -12.06400 1.000 21.83000 ? 193 LYS A CA  1 
ATOM   1114 C C   . LYS A 1 149 ? 58.22600 52.14500 -11.12500 1.000 24.52000 ? 193 LYS A C   1 
ATOM   1115 O O   . LYS A 1 149 ? 57.44800 53.00300 -11.55700 1.000 24.26000 ? 193 LYS A O   1 
ATOM   1116 C CB  . LYS A 1 149 ? 57.76000 49.88300 -12.06100 1.000 23.71000 ? 193 LYS A CB  1 
ATOM   1117 C CG  . LYS A 1 149 ? 58.06600 48.81800 -13.10200 1.000 26.07000 ? 193 LYS A CG  1 
ATOM   1118 C CD  . LYS A 1 149 ? 57.94500 49.36800 -14.51300 1.000 27.17000 ? 193 LYS A CD  1 
ATOM   1119 C CE  . LYS A 1 149 ? 58.18300 48.28000 -15.54700 1.000 27.81000 ? 193 LYS A CE  1 
ATOM   1120 N NZ  . LYS A 1 149 ? 57.94700 48.77500 -16.92900 1.000 37.07000 ? 193 LYS A NZ  1 
ATOM   1121 N N   . ALA A 1 150 ? 58.63600 52.13100 -9.85800  1.000 23.55000 ? 194 ALA A N   1 
ATOM   1122 C CA  . ALA A 1 150 ? 58.14800 53.10700 -8.89300  1.000 20.47000 ? 194 ALA A CA  1 
ATOM   1123 C C   . ALA A 1 150 ? 59.20900 53.34700 -7.82800  1.000 20.60000 ? 194 ALA A C   1 
ATOM   1124 O O   . ALA A 1 150 ? 60.14400 52.56000 -7.66400  1.000 21.58000 ? 194 ALA A O   1 
ATOM   1125 C CB  . ALA A 1 150 ? 56.83400 52.65100 -8.24700  1.000 19.51000 ? 194 ALA A CB  1 
ATOM   1126 N N   . SER A 1 151 ? 59.04400 54.45300 -7.10100  1.000 20.96000 ? 195 SER A N   1 
ATOM   1127 C CA  . SER A 1 151 ? 59.96000 54.84500 -6.03600  1.000 20.79000 ? 195 SER A CA  1 
ATOM   1128 C C   . SER A 1 151 ? 59.20700 55.69700 -5.02700  1.000 20.18000 ? 195 SER A C   1 
ATOM   1129 O O   . SER A 1 151 ? 58.52900 56.65400 -5.41100  1.000 19.43000 ? 195 SER A O   1 
ATOM   1130 C CB  . SER A 1 151 ? 61.15600 55.62100 -6.59200  1.000 19.84000 ? 195 SER A CB  1 
ATOM   1131 O OG  . SER A 1 151 ? 61.98900 56.10000 -5.55100  1.000 22.49000 ? 195 SER A OG  1 
ATOM   1132 N N   . ILE A 1 152 ? 59.32300 55.35000 -3.74700  1.000 21.09000 ? 196 ILE A N   1 
ATOM   1133 C CA  . ILE A 1 152 ? 58.62800 56.07400 -2.68300  1.000 20.06000 ? 196 ILE A CA  1 
ATOM   1134 C C   . ILE A 1 152 ? 59.61000 56.42800 -1.57000  1.000 19.67000 ? 196 ILE A C   1 
ATOM   1135 O O   . ILE A 1 152 ? 59.83100 55.61800 -0.65800  1.000 18.78000 ? 196 ILE A O   1 
ATOM   1136 C CB  . ILE A 1 152 ? 57.44800 55.25900 -2.12800  1.000 19.43000 ? 196 ILE A CB  1 
ATOM   1137 C CG1 . ILE A 1 152 ? 56.51800 54.81300 -3.26000  1.000 20.63000 ? 196 ILE A CG1 1 
ATOM   1138 C CG2 . ILE A 1 152 ? 56.66800 56.07600 -1.10600  1.000 17.84000 ? 196 ILE A CG2 1 
ATOM   1139 C CD1 . ILE A 1 152 ? 55.34100 53.98600 -2.79600  1.000 20.35000 ? 196 ILE A CD1 1 
ATOM   1140 N N   . PRO A 1 153 ? 60.23200 57.61000 -1.60700  1.000 20.81000 ? 197 PRO A N   1 
ATOM   1141 C CA  . PRO A 1 153 ? 61.07500 58.05600 -0.48600  1.000 20.75000 ? 197 PRO A CA  1 
ATOM   1142 C C   . PRO A 1 153 ? 60.21500 58.60600 0.64400   1.000 18.11000 ? 197 PRO A C   1 
ATOM   1143 O O   . PRO A 1 153 ? 59.47100 59.57200 0.46000   1.000 17.85000 ? 197 PRO A O   1 
ATOM   1144 C CB  . PRO A 1 153 ? 61.95000 59.15100 -1.11300  1.000 19.78000 ? 197 PRO A CB  1 
ATOM   1145 C CG  . PRO A 1 153 ? 61.79300 58.98500 -2.60100  1.000 20.76000 ? 197 PRO A CG  1 
ATOM   1146 C CD  . PRO A 1 153 ? 60.41200 58.45800 -2.79400  1.000 20.23000 ? 197 PRO A CD  1 
ATOM   1147 N N   . LEU A 1 154 ? 60.32400 57.99000 1.81700   1.000 21.47000 ? 198 LEU A N   1 
ATOM   1148 C CA  . LEU A 1 154 ? 59.52900 58.35800 2.98300   1.000 18.92000 ? 198 LEU A CA  1 
ATOM   1149 C C   . LEU A 1 154 ? 60.36400 59.25200 3.89000   1.000 16.53000 ? 198 LEU A C   1 
ATOM   1150 O O   . LEU A 1 154 ? 61.38100 58.80800 4.43300   1.000 19.06000 ? 198 LEU A O   1 
ATOM   1151 C CB  . LEU A 1 154 ? 59.06600 57.11100 3.73400   1.000 19.14000 ? 198 LEU A CB  1 
ATOM   1152 C CG  . LEU A 1 154 ? 58.22000 56.11500 2.94100   1.000 17.09000 ? 198 LEU A CG  1 
ATOM   1153 C CD1 . LEU A 1 154 ? 58.22500 54.75600 3.61600   1.000 19.46000 ? 198 LEU A CD1 1 
ATOM   1154 C CD2 . LEU A 1 154 ? 56.80200 56.63100 2.79500   1.000 17.51000 ? 198 LEU A CD2 1 
ATOM   1155 N N   . THR A 1 155 ? 59.92100 60.49800 4.06100   1.000 17.33000 ? 199 THR A N   1 
ATOM   1156 C CA  . THR A 1 155 ? 60.63300 61.54300 4.79400   1.000 18.55000 ? 199 THR A CA  1 
ATOM   1157 C C   . THR A 1 155 ? 62.12900 61.49500 4.45500   1.000 20.36000 ? 199 THR A C   1 
ATOM   1158 O O   . THR A 1 155 ? 62.96600 61.35400 5.35400   1.000 19.07000 ? 199 THR A O   1 
ATOM   1159 C CB  . THR A 1 155 ? 60.40500 61.42100 6.29700   1.000 19.95000 ? 199 THR A CB  1 
ATOM   1160 O OG1 . THR A 1 155 ? 60.86800 60.14500 6.75500   1.000 20.83000 ? 199 THR A OG1 1 
ATOM   1161 C CG2 . THR A 1 155 ? 58.92500 61.55800 6.61600   1.000 18.77000 ? 199 THR A CG2 1 
ATOM   1162 N N   . PRO A 1 156 ? 62.48900 61.62500 3.18000   1.000 20.00000 ? 200 PRO A N   1 
ATOM   1163 C CA  . PRO A 1 156 ? 63.84500 61.26600 2.75700   1.000 17.07000 ? 200 PRO A CA  1 
ATOM   1164 C C   . PRO A 1 156 ? 64.89400 62.23000 3.27800   1.000 17.66000 ? 200 PRO A C   1 
ATOM   1165 O O   . PRO A 1 156 ? 64.63300 63.41100 3.52300   1.000 20.04000 ? 200 PRO A O   1 
ATOM   1166 C CB  . PRO A 1 156 ? 63.76100 61.32000 1.22900   1.000 18.77000 ? 200 PRO A CB  1 
ATOM   1167 C CG  . PRO A 1 156 ? 62.72400 62.34600 0.96400   1.000 17.78000 ? 200 PRO A CG  1 
ATOM   1168 C CD  . PRO A 1 156 ? 61.70900 62.21300 2.07600   1.000 21.05000 ? 200 PRO A CD  1 
ATOM   1169 N N   . TRP A 1 157 ? 66.09900 61.69700 3.44500   1.000 18.45000 ? 201 TRP A N   1 
ATOM   1170 C CA  . TRP A 1 157 ? 67.27100 62.46600 3.83200   1.000 19.09000 ? 201 TRP A CA  1 
ATOM   1171 C C   . TRP A 1 157 ? 68.37200 62.18700 2.82300   1.000 18.06000 ? 201 TRP A C   1 
ATOM   1172 O O   . TRP A 1 157 ? 68.67000 61.02400 2.53400   1.000 17.84000 ? 201 TRP A O   1 
ATOM   1173 C CB  . TRP A 1 157 ? 67.73800 62.09900 5.24400   1.000 18.74000 ? 201 TRP A CB  1 
ATOM   1174 C CG  . TRP A 1 157 ? 68.83600 62.97300 5.76500   1.000 18.55000 ? 201 TRP A CG  1 
ATOM   1175 C CD1 . TRP A 1 157 ? 68.70200 64.04300 6.59700   1.000 20.13000 ? 201 TRP A CD1 1 
ATOM   1176 C CD2 . TRP A 1 157 ? 70.23900 62.85000 5.49300   1.000 19.29000 ? 201 TRP A CD2 1 
ATOM   1177 N NE1 . TRP A 1 157 ? 69.93000 64.59700 6.85900   1.000 22.23000 ? 201 TRP A NE1 1 
ATOM   1178 C CE2 . TRP A 1 157 ? 70.89100 63.88200 6.19400   1.000 21.59000 ? 201 TRP A CE2 1 
ATOM   1179 C CE3 . TRP A 1 157 ? 71.00700 61.96700 4.72600   1.000 18.75000 ? 201 TRP A CE3 1 
ATOM   1180 C CZ2 . TRP A 1 157 ? 72.27200 64.05700 6.15000   1.000 23.49000 ? 201 TRP A CZ2 1 
ATOM   1181 C CZ3 . TRP A 1 157 ? 72.37800 62.14300 4.68400   1.000 17.56000 ? 201 TRP A CZ3 1 
ATOM   1182 C CH2 . TRP A 1 157 ? 72.99600 63.17900 5.39200   1.000 20.75000 ? 201 TRP A CH2 1 
ATOM   1183 N N   . HIS A 1 158 ? 68.96900 63.25000 2.28900   1.000 19.21000 ? 202 HIS A N   1 
ATOM   1184 C CA  . HIS A 1 158 ? 70.06500 63.11600 1.34300   1.000 19.22000 ? 202 HIS A CA  1 
ATOM   1185 C C   . HIS A 1 158 ? 70.77500 64.45600 1.22600   1.000 18.95000 ? 202 HIS A C   1 
ATOM   1186 O O   . HIS A 1 158 ? 70.13200 65.50900 1.24500   1.000 21.42000 ? 202 HIS A O   1 
ATOM   1187 C CB  . HIS A 1 158 ? 69.56500 62.64900 -0.03100  1.000 20.85000 ? 202 HIS A CB  1 
ATOM   1188 C CG  . HIS A 1 158 ? 70.59000 61.90400 -0.82900  1.000 20.45000 ? 202 HIS A CG  1 
ATOM   1189 N ND1 . HIS A 1 158 ? 71.89800 62.32300 -0.94100  1.000 22.67000 ? 202 HIS A ND1 1 
ATOM   1190 C CD2 . HIS A 1 158 ? 70.50000 60.76000 -1.54700  1.000 19.74000 ? 202 HIS A CD2 1 
ATOM   1191 C CE1 . HIS A 1 158 ? 72.56800 61.47200 -1.69800  1.000 20.46000 ? 202 HIS A CE1 1 
ATOM   1192 N NE2 . HIS A 1 158 ? 71.74300 60.51400 -2.07800  1.000 19.32000 ? 202 HIS A NE2 1 
ATOM   1193 N N   . LEU A 1 159 ? 72.10500 64.40200 1.11600   1.000 19.48000 ? 203 LEU A N   1 
ATOM   1194 C CA  . LEU A 1 159 ? 72.91000 65.60200 0.91100   1.000 22.40000 ? 203 LEU A CA  1 
ATOM   1195 C C   . LEU A 1 159 ? 72.77400 66.15600 -0.50100  1.000 23.98000 ? 203 LEU A C   1 
ATOM   1196 O O   . LEU A 1 159 ? 72.87800 67.37100 -0.69600  1.000 22.53000 ? 203 LEU A O   1 
ATOM   1197 C CB  . LEU A 1 159 ? 74.37700 65.29600 1.19600   1.000 25.86000 ? 203 LEU A CB  1 
ATOM   1198 C CG  . LEU A 1 159 ? 74.64800 64.73800 2.58600   1.000 26.51000 ? 203 LEU A CG  1 
ATOM   1199 C CD1 . LEU A 1 159 ? 76.04100 64.14900 2.64700   1.000 23.82000 ? 203 LEU A CD1 1 
ATOM   1200 C CD2 . LEU A 1 159 ? 74.46300 65.83500 3.62500   1.000 29.65000 ? 203 LEU A CD2 1 
ATOM   1201 N N   . ASP A 1 160 ? 72.56500 65.29400 -1.49300  1.000 24.09000 ? 204 ASP A N   1 
ATOM   1202 C CA  . ASP A 1 160 ? 72.40800 65.74200 -2.87100  1.000 25.50000 ? 204 ASP A CA  1 
ATOM   1203 C C   . ASP A 1 160 ? 70.95800 66.14800 -3.10300  1.000 21.93000 ? 204 ASP A C   1 
ATOM   1204 O O   . ASP A 1 160 ? 70.04400 65.34200 -2.90300  1.000 21.89000 ? 204 ASP A O   1 
ATOM   1205 C CB  . ASP A 1 160 ? 72.83300 64.64400 -3.84300  1.000 23.66000 ? 204 ASP A CB  1 
ATOM   1206 C CG  . ASP A 1 160 ? 74.27600 64.22800 -3.65400  1.000 26.30000 ? 204 ASP A CG  1 
ATOM   1207 O OD1 . ASP A 1 160 ? 75.08600 65.08000 -3.22900  1.000 30.62000 ? 204 ASP A OD1 1 
ATOM   1208 O OD2 . ASP A 1 160 ? 74.60300 63.05400 -3.92600  1.000 32.83000 ? 204 ASP A OD2 1 
ATOM   1209 N N   . LYS A 1 161 ? 70.74800 67.39200 -3.53000  1.000 22.48000 ? 205 LYS A N   1 
ATOM   1210 C CA  . LYS A 1 161 ? 69.41200 67.95900 -3.66000  1.000 23.13000 ? 205 LYS A CA  1 
ATOM   1211 C C   . LYS A 1 161 ? 68.89400 67.97500 -5.09400  1.000 23.69000 ? 205 LYS A C   1 
ATOM   1212 O O   . LYS A 1 161 ? 67.74600 68.37100 -5.31500  1.000 24.83000 ? 205 LYS A O   1 
ATOM   1213 C CB  . LYS A 1 161 ? 69.39200 69.38500 -3.09800  1.000 22.60000 ? 205 LYS A CB  1 
ATOM   1214 C CG  . LYS A 1 161 ? 70.08100 69.53700 -1.75100  1.000 25.21000 ? 205 LYS A CG  1 
ATOM   1215 C CD  . LYS A 1 161 ? 69.41200 68.69000 -0.68200  1.000 24.12000 ? 205 LYS A CD  1 
ATOM   1216 C CE  . LYS A 1 161 ? 70.12000 68.84000 0.65400   1.000 23.49000 ? 205 LYS A CE  1 
ATOM   1217 N NZ  . LYS A 1 161 ? 69.52600 67.96600 1.70200   1.000 22.66000 ? 205 LYS A NZ  1 
ATOM   1218 N N   . THR A 1 162 ? 69.70000 67.55700 -6.06700  1.000 28.95000 ? 206 THR A N   1 
ATOM   1219 C CA  . THR A 1 162 ? 69.33600 67.60900 -7.47800  1.000 27.12000 ? 206 THR A CA  1 
ATOM   1220 C C   . THR A 1 162 ? 69.07000 66.20300 -7.99700  1.000 24.80000 ? 206 THR A C   1 
ATOM   1221 O O   . THR A 1 162 ? 69.93300 65.32600 -7.89400  1.000 25.95000 ? 206 THR A O   1 
ATOM   1222 C CB  . THR A 1 162 ? 70.44200 68.26600 -8.30700  1.000 28.03000 ? 206 THR A CB  1 
ATOM   1223 O OG1 . THR A 1 162 ? 70.76400 69.54700 -7.75100  1.000 28.02000 ? 206 THR A OG1 1 
ATOM   1224 C CG2 . THR A 1 162 ? 69.99300 68.44100 -9.75400  1.000 30.27000 ? 206 THR A CG2 1 
ATOM   1225 N N   . TRP A 1 163 ? 67.88400 65.99800 -8.56400  1.000 24.61000 ? 207 TRP A N   1 
ATOM   1226 C CA  . TRP A 1 163 ? 67.48600 64.70100 -9.10100  1.000 24.71000 ? 207 TRP A CA  1 
ATOM   1227 C C   . TRP A 1 163 ? 66.80900 64.87500 -10.45200 1.000 25.05000 ? 207 TRP A C   1 
ATOM   1228 O O   . TRP A 1 163 ? 65.78300 64.25300 -10.73800 1.000 23.33000 ? 207 TRP A O   1 
ATOM   1229 C CB  . TRP A 1 163 ? 66.57600 63.96100 -8.12200  1.000 23.97000 ? 207 TRP A CB  1 
ATOM   1230 C CG  . TRP A 1 163 ? 67.22800 63.73700 -6.78800  1.000 25.84000 ? 207 TRP A CG  1 
ATOM   1231 C CD1 . TRP A 1 163 ? 67.13100 64.52900 -5.67900  1.000 25.09000 ? 207 TRP A CD1 1 
ATOM   1232 C CD2 . TRP A 1 163 ? 68.10300 62.65900 -6.43500  1.000 23.48000 ? 207 TRP A CD2 1 
ATOM   1233 N NE1 . TRP A 1 163 ? 67.88500 64.00400 -4.65600  1.000 24.50000 ? 207 TRP A NE1 1 
ATOM   1234 C CE2 . TRP A 1 163 ? 68.49000 62.85600 -5.09400  1.000 22.24000 ? 207 TRP A CE2 1 
ATOM   1235 C CE3 . TRP A 1 163 ? 68.59200 61.54200 -7.12100  1.000 23.15000 ? 207 TRP A CE3 1 
ATOM   1236 C CZ2 . TRP A 1 163 ? 69.34300 61.97900 -4.42800  1.000 21.47000 ? 207 TRP A CZ2 1 
ATOM   1237 C CZ3 . TRP A 1 163 ? 69.43700 60.67300 -6.45700  1.000 24.30000 ? 207 TRP A CZ3 1 
ATOM   1238 C CH2 . TRP A 1 163 ? 69.80500 60.89600 -5.12400  1.000 22.65000 ? 207 TRP A CH2 1 
ATOM   1239 N N   . GLY A 1 164 ? 67.37400 65.72600 -11.30700 1.000 26.58000 ? 208 GLY A N   1 
ATOM   1240 C CA  . GLY A 1 164 ? 66.73300 66.00800 -12.58100 1.000 28.68000 ? 208 GLY A CA  1 
ATOM   1241 C C   . GLY A 1 164 ? 66.89400 64.92500 -13.62000 1.000 28.12000 ? 208 GLY A C   1 
ATOM   1242 O O   . GLY A 1 164 ? 66.35800 65.06300 -14.72600 1.000 30.27000 ? 208 GLY A O   1 
ATOM   1243 N N   . GLN A 1 165 ? 67.62600 63.86200 -13.29900 1.000 27.17000 ? 209 GLN A N   1 
ATOM   1244 C CA  . GLN A 1 165 ? 67.83700 62.74200 -14.20700 1.000 24.79000 ? 209 GLN A CA  1 
ATOM   1245 C C   . GLN A 1 165 ? 67.03000 61.51100 -13.81600 1.000 24.40000 ? 209 GLN A C   1 
ATOM   1246 O O   . GLN A 1 165 ? 67.15700 60.47200 -14.47100 1.000 24.10000 ? 209 GLN A O   1 
ATOM   1247 C CB  . GLN A 1 165 ? 69.33000 62.39600 -14.27300 1.000 24.97000 ? 209 GLN A CB  1 
ATOM   1248 C CG  . GLN A 1 165 ? 70.21500 63.55100 -14.73800 1.000 29.78000 ? 209 GLN A CG  1 
ATOM   1249 C CD  . GLN A 1 165 ? 69.76600 64.14400 -16.06300 1.000 30.10000 ? 209 GLN A CD  1 
ATOM   1250 O OE1 . GLN A 1 165 ? 69.49100 63.42100 -17.02100 1.000 30.21000 ? 209 GLN A OE1 1 
ATOM   1251 N NE2 . GLN A 1 165 ? 69.68200 65.47000 -16.12000 1.000 28.87000 ? 209 GLN A NE2 1 
ATOM   1252 N N   . VAL A 1 166 ? 66.20800 61.59600 -12.76700 1.000 26.01000 ? 210 VAL A N   1 
ATOM   1253 C CA  . VAL A 1 166 ? 65.38400 60.46100 -12.36400 1.000 24.93000 ? 210 VAL A CA  1 
ATOM   1254 C C   . VAL A 1 166 ? 64.31000 60.21300 -13.41600 1.000 22.99000 ? 210 VAL A C   1 
ATOM   1255 O O   . VAL A 1 166 ? 63.57400 61.12900 -13.80400 1.000 21.85000 ? 210 VAL A O   1 
ATOM   1256 C CB  . VAL A 1 166 ? 64.76500 60.71200 -10.98000 1.000 21.19000 ? 210 VAL A CB  1 
ATOM   1257 C CG1 . VAL A 1 166 ? 63.74900 59.62800 -10.63900 1.000 20.17000 ? 210 VAL A CG1 1 
ATOM   1258 C CG2 . VAL A 1 166 ? 65.85100 60.77500 -9.91700  1.000 21.19000 ? 210 VAL A CG2 1 
ATOM   1259 N N   . GLN A 1 167 ? 64.21800 58.96900 -13.88600 1.000 21.58000 ? 211 GLN A N   1 
ATOM   1260 C CA  . GLN A 1 167 ? 63.22700 58.57700 -14.87900 1.000 22.90000 ? 211 GLN A CA  1 
ATOM   1261 C C   . GLN A 1 167 ? 62.13500 57.68300 -14.30900 1.000 24.27000 ? 211 GLN A C   1 
ATOM   1262 O O   . GLN A 1 167 ? 61.25400 57.24700 -15.05900 1.000 21.94000 ? 211 GLN A O   1 
ATOM   1263 C CB  . GLN A 1 167 ? 63.90400 57.86100 -16.05500 1.000 24.34000 ? 211 GLN A CB  1 
ATOM   1264 C CG  . GLN A 1 167 ? 65.01400 58.65400 -16.71900 1.000 21.64000 ? 211 GLN A CG  1 
ATOM   1265 C CD  . GLN A 1 167 ? 65.70800 57.86800 -17.81400 1.000 24.45000 ? 211 GLN A CD  1 
ATOM   1266 O OE1 . GLN A 1 167 ? 65.23900 57.81800 -18.95000 1.000 25.74000 ? 211 GLN A OE1 1 
ATOM   1267 N NE2 . GLN A 1 167 ? 66.82800 57.24300 -17.47400 1.000 23.37000 ? 211 GLN A NE2 1 
ATOM   1268 N N   . VAL A 1 168 ? 62.16900 57.40100 -13.01100 1.000 23.77000 ? 212 VAL A N   1 
ATOM   1269 C CA  . VAL A 1 168 ? 61.22200 56.49100 -12.37200 1.000 20.84000 ? 212 VAL A CA  1 
ATOM   1270 C C   . VAL A 1 168 ? 60.15400 57.30600 -11.65200 1.000 21.34000 ? 212 VAL A C   1 
ATOM   1271 O O   . VAL A 1 168 ? 60.48400 58.29300 -10.97800 1.000 22.32000 ? 212 VAL A O   1 
ATOM   1272 C CB  . VAL A 1 168 ? 61.94400 55.54200 -11.40100 1.000 19.57000 ? 212 VAL A CB  1 
ATOM   1273 C CG1 . VAL A 1 168 ? 60.96000 54.59200 -10.74400 1.000 19.76000 ? 212 VAL A CG1 1 
ATOM   1274 C CG2 . VAL A 1 168 ? 63.03000 54.77000 -12.12900 1.000 22.58000 ? 212 VAL A CG2 1 
ATOM   1275 N N   . PRO A 1 169 ? 58.86900 56.94400 -11.77500 1.000 20.11000 ? 213 PRO A N   1 
ATOM   1276 C CA  . PRO A 1 169 ? 57.82200 57.65000 -11.02100 1.000 22.57000 ? 213 PRO A CA  1 
ATOM   1277 C C   . PRO A 1 169 ? 58.09800 57.67600 -9.52600  1.000 21.31000 ? 213 PRO A C   1 
ATOM   1278 O O   . PRO A 1 169 ? 58.16000 56.62500 -8.88000  1.000 22.28000 ? 213 PRO A O   1 
ATOM   1279 C CB  . PRO A 1 169 ? 56.55800 56.84400 -11.34600 1.000 21.80000 ? 213 PRO A CB  1 
ATOM   1280 C CG  . PRO A 1 169 ? 56.83800 56.24500 -12.68200 1.000 22.26000 ? 213 PRO A CG  1 
ATOM   1281 C CD  . PRO A 1 169 ? 58.30900 55.94400 -12.70000 1.000 22.41000 ? 213 PRO A CD  1 
ATOM   1282 N N   . THR A 1 170 ? 58.26200 58.87300 -8.96700  1.000 22.66000 ? 214 THR A N   1 
ATOM   1283 C CA  . THR A 1 170 ? 58.70300 59.05100 -7.59000  1.000 20.79000 ? 214 THR A CA  1 
ATOM   1284 C C   . THR A 1 170 ? 57.60200 59.71600 -6.77400  1.000 19.54000 ? 214 THR A C   1 
ATOM   1285 O O   . THR A 1 170 ? 57.05000 60.74000 -7.18700  1.000 20.00000 ? 214 THR A O   1 
ATOM   1286 C CB  . THR A 1 170 ? 59.98900 59.88100 -7.54100  1.000 21.24000 ? 214 THR A CB  1 
ATOM   1287 O OG1 . THR A 1 170 ? 61.00800 59.22300 -8.30600  1.000 21.57000 ? 214 THR A OG1 1 
ATOM   1288 C CG2 . THR A 1 170 ? 60.47200 60.05200 -6.11000  1.000 19.76000 ? 214 THR A CG2 1 
ATOM   1289 N N   . PHE A 1 171 ? 57.28900 59.13100 -5.61800  1.000 18.81000 ? 215 PHE A N   1 
ATOM   1290 C CA  . PHE A 1 171 ? 56.27100 59.64100 -4.69900  1.000 18.86000 ? 215 PHE A CA  1 
ATOM   1291 C C   . PHE A 1 171 ? 56.96100 59.98200 -3.38200  1.000 18.35000 ? 215 PHE A C   1 
ATOM   1292 O O   . PHE A 1 171 ? 57.29000 59.08700 -2.59700  1.000 18.84000 ? 215 PHE A O   1 
ATOM   1293 C CB  . PHE A 1 171 ? 55.16200 58.61400 -4.49500  1.000 18.34000 ? 215 PHE A CB  1 
ATOM   1294 C CG  . PHE A 1 171 ? 54.03700 59.09000 -3.61500  1.000 17.78000 ? 215 PHE A CG  1 
ATOM   1295 C CD1 . PHE A 1 171 ? 53.78900 60.44200 -3.43600  1.000 18.22000 ? 215 PHE A CD1 1 
ATOM   1296 C CD2 . PHE A 1 171 ? 53.23000 58.17500 -2.96200  1.000 18.97000 ? 215 PHE A CD2 1 
ATOM   1297 C CE1 . PHE A 1 171 ? 52.75500 60.86900 -2.62500  1.000 17.96000 ? 215 PHE A CE1 1 
ATOM   1298 C CE2 . PHE A 1 171 ? 52.19600 58.59600 -2.15100  1.000 18.35000 ? 215 PHE A CE2 1 
ATOM   1299 C CZ  . PHE A 1 171 ? 51.95700 59.94300 -1.98300  1.000 16.18000 ? 215 PHE A CZ  1 
ATOM   1300 N N   . ILE A 1 172 ? 57.16900 61.26900 -3.13200  1.000 19.99000 ? 216 ILE A N   1 
ATOM   1301 C CA  . ILE A 1 172 ? 57.86200 61.72300 -1.93200  1.000 19.95000 ? 216 ILE A CA  1 
ATOM   1302 C C   . ILE A 1 172 ? 56.83300 62.07500 -0.86600  1.000 19.92000 ? 216 ILE A C   1 
ATOM   1303 O O   . ILE A 1 172 ? 55.87700 62.81400 -1.12900  1.000 19.25000 ? 216 ILE A O   1 
ATOM   1304 C CB  . ILE A 1 172 ? 58.77100 62.92300 -2.24200  1.000 20.88000 ? 216 ILE A CB  1 
ATOM   1305 C CG1 . ILE A 1 172 ? 59.81100 62.54800 -3.30000  1.000 18.24000 ? 216 ILE A CG1 1 
ATOM   1306 C CG2 . ILE A 1 172 ? 59.46000 63.40900 -0.97700  1.000 19.75000 ? 216 ILE A CG2 1 
ATOM   1307 C CD1 . ILE A 1 172 ? 60.77900 63.66700 -3.62600  1.000 19.03000 ? 216 ILE A CD1 1 
ATOM   1308 N N   . ILE A 1 173 ? 57.02400 61.54000 0.33600   1.000 20.29000 ? 217 ILE A N   1 
ATOM   1309 C CA  . ILE A 1 173 ? 56.17500 61.83600 1.48300   1.000 19.46000 ? 217 ILE A CA  1 
ATOM   1310 C C   . ILE A 1 173 ? 57.02600 62.54400 2.52600   1.000 19.32000 ? 217 ILE A C   1 
ATOM   1311 O O   . ILE A 1 173 ? 58.09000 62.04400 2.90900   1.000 19.77000 ? 217 ILE A O   1 
ATOM   1312 C CB  . ILE A 1 173 ? 55.53300 60.56300 2.06500   1.000 21.28000 ? 217 ILE A CB  1 
ATOM   1313 C CG1 . ILE A 1 173 ? 54.60400 59.91900 1.03400   1.000 19.56000 ? 217 ILE A CG1 1 
ATOM   1314 C CG2 . ILE A 1 173 ? 54.76900 60.88600 3.34000   1.000 19.92000 ? 217 ILE A CG2 1 
ATOM   1315 C CD1 . ILE A 1 173 ? 54.01600 58.59700 1.47600   1.000 16.60000 ? 217 ILE A CD1 1 
ATOM   1316 N N   . GLY A 1 174 ? 56.56500 63.70800 2.97100   1.000 19.11000 ? 218 GLY A N   1 
ATOM   1317 C CA  . GLY A 1 174 ? 57.29300 64.50700 3.93400   1.000 20.08000 ? 218 GLY A CA  1 
ATOM   1318 C C   . GLY A 1 174 ? 56.46900 64.74600 5.18400   1.000 18.62000 ? 218 GLY A C   1 
ATOM   1319 O O   . GLY A 1 174 ? 55.23800 64.75500 5.14400   1.000 18.69000 ? 218 GLY A O   1 
ATOM   1320 N N   . ALA A 1 175 ? 57.16300 64.93000 6.30200   1.000 23.08000 ? 219 ALA A N   1 
ATOM   1321 C CA  . ALA A 1 175 ? 56.53300 65.24900 7.57400   1.000 21.57000 ? 219 ALA A CA  1 
ATOM   1322 C C   . ALA A 1 175 ? 56.69800 66.73700 7.84400   1.000 19.87000 ? 219 ALA A C   1 
ATOM   1323 O O   . ALA A 1 175 ? 57.81800 67.25500 7.80400   1.000 19.84000 ? 219 ALA A O   1 
ATOM   1324 C CB  . ALA A 1 175 ? 57.14400 64.42700 8.70900   1.000 21.16000 ? 219 ALA A CB  1 
ATOM   1325 N N   . GLU A 1 176 ? 55.58100 67.41900 8.11200   1.000 20.23000 ? 220 GLU A N   1 
ATOM   1326 C CA  . GLU A 1 176 ? 55.61100 68.87300 8.25500   1.000 21.91000 ? 220 GLU A CA  1 
ATOM   1327 C C   . GLU A 1 176 ? 56.61400 69.30700 9.31500   1.000 24.35000 ? 220 GLU A C   1 
ATOM   1328 O O   . GLU A 1 176 ? 57.46300 70.17200 9.06700   1.000 25.27000 ? 220 GLU A O   1 
ATOM   1329 C CB  . GLU A 1 176 ? 54.21800 69.40000 8.59700   1.000 21.91000 ? 220 GLU A CB  1 
ATOM   1330 C CG  . GLU A 1 176 ? 54.20100 70.89000 8.90700   1.000 24.52000 ? 220 GLU A CG  1 
ATOM   1331 C CD  . GLU A 1 176 ? 52.89400 71.34600 9.51900   1.000 24.33000 ? 220 GLU A CD  1 
ATOM   1332 O OE1 . GLU A 1 176 ? 52.02700 70.48700 9.77600   1.000 27.25000 ? 220 GLU A OE1 1 
ATOM   1333 O OE2 . GLU A 1 176 ? 52.73200 72.56500 9.73800   1.000 28.08000 ? 220 GLU A OE2 1 
ATOM   1334 N N   . LEU A 1 177 ? 56.53900 68.71300 10.50500  1.000 24.62000 ? 221 LEU A N   1 
ATOM   1335 C CA  . LEU A 1 177 ? 57.38700 69.10000 11.62100  1.000 24.88000 ? 221 LEU A CA  1 
ATOM   1336 C C   . LEU A 1 177 ? 58.69100 68.31100 11.67600  1.000 24.62000 ? 221 LEU A C   1 
ATOM   1337 O O   . LEU A 1 177 ? 59.31500 68.23800 12.74100  1.000 25.82000 ? 221 LEU A O   1 
ATOM   1338 C CB  . LEU A 1 177 ? 56.62100 68.94800 12.93700  1.000 24.50000 ? 221 LEU A CB  1 
ATOM   1339 C CG  . LEU A 1 177 ? 55.31700 69.74400 13.02600  1.000 23.67000 ? 221 LEU A CG  1 
ATOM   1340 C CD1 . LEU A 1 177 ? 54.62600 69.50900 14.36000  1.000 24.92000 ? 221 LEU A CD1 1 
ATOM   1341 C CD2 . LEU A 1 177 ? 55.57900 71.22500 12.80800  1.000 25.13000 ? 221 LEU A CD2 1 
ATOM   1342 N N   . ASP A 1 178 ? 59.11400 67.72500 10.55900  1.000 23.49000 ? 222 ASP A N   1 
ATOM   1343 C CA  . ASP A 1 178 ? 60.36900 66.98400 10.52600  1.000 20.39000 ? 222 ASP A CA  1 
ATOM   1344 C C   . ASP A 1 178 ? 61.53400 67.94800 10.72400  1.000 20.70000 ? 222 ASP A C   1 
ATOM   1345 O O   . ASP A 1 178 ? 61.70500 68.89500 9.95000   1.000 20.23000 ? 222 ASP A O   1 
ATOM   1346 C CB  . ASP A 1 178 ? 60.50200 66.23000 9.20400   1.000 22.05000 ? 222 ASP A CB  1 
ATOM   1347 C CG  . ASP A 1 178 ? 61.55600 65.13700 9.25200   1.000 19.52000 ? 222 ASP A CG  1 
ATOM   1348 O OD1 . ASP A 1 178 ? 62.56500 65.30000 9.96900   1.000 22.40000 ? 222 ASP A OD1 1 
ATOM   1349 O OD2 . ASP A 1 178 ? 61.37500 64.10900 8.56700   1.000 18.32000 ? 222 ASP A OD2 1 
ATOM   1350 N N   . THR A 1 179 ? 62.32400 67.71600 11.77100  1.000 24.27000 ? 223 THR A N   1 
ATOM   1351 C CA  . THR A 1 179 ? 63.51300 68.51000 12.04100  1.000 21.18000 ? 223 THR A CA  1 
ATOM   1352 C C   . THR A 1 179 ? 64.80300 67.76500 11.74600  1.000 19.07000 ? 223 THR A C   1 
ATOM   1353 O O   . THR A 1 179 ? 65.86300 68.39600 11.68200  1.000 21.02000 ? 223 THR A O   1 
ATOM   1354 C CB  . THR A 1 179 ? 63.52900 68.97300 13.50500  1.000 23.15000 ? 223 THR A CB  1 
ATOM   1355 O OG1 . THR A 1 179 ? 63.47100 67.83000 14.36700  1.000 23.48000 ? 223 THR A OG1 1 
ATOM   1356 C CG2 . THR A 1 179 ? 62.34600 69.88400 13.79100  1.000 22.42000 ? 223 THR A CG2 1 
ATOM   1357 N N   . ILE A 1 180 ? 64.74300 66.44800 11.57900  1.000 19.35000 ? 224 ILE A N   1 
ATOM   1358 C CA  . ILE A 1 180 ? 65.91900 65.66700 11.21900  1.000 19.80000 ? 224 ILE A CA  1 
ATOM   1359 C C   . ILE A 1 180 ? 66.13400 65.66400 9.71200   1.000 22.04000 ? 224 ILE A C   1 
ATOM   1360 O O   . ILE A 1 180 ? 67.26800 65.77300 9.23800   1.000 21.60000 ? 224 ILE A O   1 
ATOM   1361 C CB  . ILE A 1 180 ? 65.77800 64.23800 11.77600  1.000 20.17000 ? 224 ILE A CB  1 
ATOM   1362 C CG1 . ILE A 1 180 ? 65.63500 64.27500 13.29900  1.000 22.88000 ? 224 ILE A CG1 1 
ATOM   1363 C CG2 . ILE A 1 180 ? 66.96600 63.39100 11.37700  1.000 21.59000 ? 224 ILE A CG2 1 
ATOM   1364 C CD1 . ILE A 1 180 ? 65.52200 62.90900 13.93300  1.000 22.98000 ? 224 ILE A CD1 1 
ATOM   1365 N N   . ALA A 1 181 ? 65.05200 65.54200 8.94700   1.000 22.56000 ? 225 ALA A N   1 
ATOM   1366 C CA  . ALA A 1 181 ? 65.07000 65.69300 7.49400   1.000 19.86000 ? 225 ALA A CA  1 
ATOM   1367 C C   . ALA A 1 181 ? 64.03400 66.75100 7.14200   1.000 18.22000 ? 225 ALA A C   1 
ATOM   1368 O O   . ALA A 1 181 ? 62.93700 66.42600 6.66900   1.000 21.35000 ? 225 ALA A O   1 
ATOM   1369 C CB  . ALA A 1 181 ? 64.78100 64.36800 6.78900   1.000 18.32000 ? 225 ALA A CB  1 
ATOM   1370 N N   . PRO A 1 182 ? 64.34400 68.02900 7.37200   1.000 18.37000 ? 226 PRO A N   1 
ATOM   1371 C CA  . PRO A 1 182 ? 63.34500 69.08100 7.14200   1.000 18.12000 ? 226 PRO A CA  1 
ATOM   1372 C C   . PRO A 1 182 ? 62.89700 69.11000 5.68900   1.000 20.80000 ? 226 PRO A C   1 
ATOM   1373 O O   . PRO A 1 182 ? 63.71400 69.08100 4.76700   1.000 21.82000 ? 226 PRO A O   1 
ATOM   1374 C CB  . PRO A 1 182 ? 64.08500 70.36800 7.52800   1.000 17.47000 ? 226 PRO A CB  1 
ATOM   1375 C CG  . PRO A 1 182 ? 65.23100 69.92600 8.37200   1.000 19.85000 ? 226 PRO A CG  1 
ATOM   1376 C CD  . PRO A 1 182 ? 65.62300 68.58000 7.84700   1.000 18.22000 ? 226 PRO A CD  1 
ATOM   1377 N N   . VAL A 1 183 ? 61.57700 69.17000 5.49400   1.000 21.24000 ? 227 VAL A N   1 
ATOM   1378 C CA  . VAL A 1 183 ? 61.02100 69.16200 4.14500   1.000 20.52000 ? 227 VAL A CA  1 
ATOM   1379 C C   . VAL A 1 183 ? 61.46300 70.39100 3.36200   1.000 20.79000 ? 227 VAL A C   1 
ATOM   1380 O O   . VAL A 1 183 ? 61.53900 70.35300 2.12900   1.000 23.16000 ? 227 VAL A O   1 
ATOM   1381 C CB  . VAL A 1 183 ? 59.48600 69.04600 4.19100   1.000 18.98000 ? 227 VAL A CB  1 
ATOM   1382 C CG1 . VAL A 1 183 ? 59.06700 67.74500 4.86500   1.000 22.14000 ? 227 VAL A CG1 1 
ATOM   1383 C CG2 . VAL A 1 183 ? 58.87700 70.24500 4.90400   1.000 20.46000 ? 227 VAL A CG2 1 
ATOM   1384 N N   . SER A 1 184 ? 61.77200 71.49300 4.05200   1.000 21.98000 ? 228 SER A N   1 
ATOM   1385 C CA  . SER A 1 184 ? 62.22000 72.69500 3.35400   1.000 22.36000 ? 228 SER A CA  1 
ATOM   1386 C C   . SER A 1 184 ? 63.59000 72.50100 2.71900   1.000 23.16000 ? 228 SER A C   1 
ATOM   1387 O O   . SER A 1 184 ? 63.89000 73.12700 1.69600   1.000 23.99000 ? 228 SER A O   1 
ATOM   1388 C CB  . SER A 1 184 ? 62.25400 73.88400 4.31200   1.000 22.92000 ? 228 SER A CB  1 
ATOM   1389 O OG  . SER A 1 184 ? 63.27400 73.72200 5.28200   1.000 23.66000 ? 228 SER A OG  1 
ATOM   1390 N N   . THR A 1 185 ? 64.43300 71.65000 3.30300   1.000 20.74000 ? 229 THR A N   1 
ATOM   1391 C CA  . THR A 1 185 ? 65.77600 71.42400 2.78900   1.000 20.61000 ? 229 THR A CA  1 
ATOM   1392 C C   . THR A 1 185 ? 65.96900 70.04100 2.18300   1.000 20.83000 ? 229 THR A C   1 
ATOM   1393 O O   . THR A 1 185 ? 66.99600 69.80800 1.53700   1.000 21.96000 ? 229 THR A O   1 
ATOM   1394 C CB  . THR A 1 185 ? 66.81800 71.63600 3.89800   1.000 21.80000 ? 229 THR A CB  1 
ATOM   1395 O OG1 . THR A 1 185 ? 66.58200 70.71000 4.96600   1.000 19.89000 ? 229 THR A OG1 1 
ATOM   1396 C CG2 . THR A 1 185 ? 66.74400 73.05600 4.43700   1.000 20.22000 ? 229 THR A CG2 1 
ATOM   1397 N N   . HIS A 1 186 ? 65.01800 69.12700 2.36600   1.000 20.87000 ? 230 HIS A N   1 
ATOM   1398 C CA  . HIS A 1 186 ? 65.15400 67.77200 1.84600   1.000 19.71000 ? 230 HIS A CA  1 
ATOM   1399 C C   . HIS A 1 186 ? 63.99600 67.40400 0.92500   1.000 20.42000 ? 230 HIS A C   1 
ATOM   1400 O O   . HIS A 1 186 ? 64.13900 67.45000 -0.30000  1.000 23.18000 ? 230 HIS A O   1 
ATOM   1401 C CB  . HIS A 1 186 ? 65.25500 66.76600 2.99600   1.000 20.86000 ? 230 HIS A CB  1 
ATOM   1402 C CG  . HIS A 1 186 ? 66.55700 66.82200 3.73300   1.000 19.99000 ? 230 HIS A CG  1 
ATOM   1403 N ND1 . HIS A 1 186 ? 67.61100 65.98200 3.44500   1.000 20.90000 ? 230 HIS A ND1 1 
ATOM   1404 C CD2 . HIS A 1 186 ? 66.97900 67.62200 4.74000   1.000 19.62000 ? 230 HIS A CD2 1 
ATOM   1405 C CE1 . HIS A 1 186 ? 68.62500 66.26000 4.24400   1.000 20.72000 ? 230 HIS A CE1 1 
ATOM   1406 N NE2 . HIS A 1 186 ? 68.26800 67.25100 5.04000   1.000 18.95000 ? 230 HIS A NE2 1 
ATOM   1407 N N   . ALA A 1 187 ? 62.84500 67.05900 1.51000   1.000 22.33000 ? 231 ALA A N   1 
ATOM   1408 C CA  . ALA A 1 187 ? 61.74600 66.47700 0.74200   1.000 22.08000 ? 231 ALA A CA  1 
ATOM   1409 C C   . ALA A 1 187 ? 61.30600 67.38700 -0.40000  1.000 21.61000 ? 231 ALA A C   1 
ATOM   1410 O O   . ALA A 1 187 ? 61.17100 66.94000 -1.54600  1.000 21.68000 ? 231 ALA A O   1 
ATOM   1411 C CB  . ALA A 1 187 ? 60.56900 66.16800 1.66700   1.000 18.85000 ? 231 ALA A CB  1 
ATOM   1412 N N   . LYS A 1 188 ? 61.06500 68.67000 -0.10800  1.000 21.77000 ? 232 LYS A N   1 
ATOM   1413 C CA  . LYS A 1 188 ? 60.61300 69.57700 -1.16300  1.000 22.82000 ? 232 LYS A CA  1 
ATOM   1414 C C   . LYS A 1 188 ? 61.69500 69.84500 -2.20100  1.000 24.46000 ? 232 LYS A C   1 
ATOM   1415 O O   . LYS A 1 188 ? 61.38400 69.80800 -3.40500  1.000 23.67000 ? 232 LYS A O   1 
ATOM   1416 C CB  . LYS A 1 188 ? 60.09100 70.88000 -0.55500  1.000 20.54000 ? 232 LYS A CB  1 
ATOM   1417 C CG  . LYS A 1 188 ? 58.84300 70.73500 0.26700   1.000 20.63000 ? 232 LYS A CG  1 
ATOM   1418 C CD  . LYS A 1 188 ? 58.30900 72.10200 0.61900   1.000 21.41000 ? 232 LYS A CD  1 
ATOM   1419 C CE  . LYS A 1 188 ? 57.04500 71.99400 1.42900   1.000 25.08000 ? 232 LYS A CE  1 
ATOM   1420 N NZ  . LYS A 1 188 ? 56.37700 73.31600 1.56600   1.000 29.97000 ? 232 LYS A NZ  1 
ATOM   1421 N N   . PRO A 1 189 ? 62.95000 70.14500 -1.83400  1.000 22.57000 ? 233 PRO A N   1 
ATOM   1422 C CA  . PRO A 1 189 ? 63.98400 70.28500 -2.87300  1.000 22.49000 ? 233 PRO A CA  1 
ATOM   1423 C C   . PRO A 1 189 ? 64.13800 69.05500 -3.74900  1.000 23.96000 ? 233 PRO A C   1 
ATOM   1424 O O   . PRO A 1 189 ? 64.40000 69.19100 -4.95000  1.000 26.26000 ? 233 PRO A O   1 
ATOM   1425 C CB  . PRO A 1 189 ? 65.25200 70.56600 -2.05800  1.000 22.80000 ? 233 PRO A CB  1 
ATOM   1426 C CG  . PRO A 1 189 ? 64.75700 71.24200 -0.84500  1.000 22.00000 ? 233 PRO A CG  1 
ATOM   1427 C CD  . PRO A 1 189 ? 63.46000 70.56600 -0.51400  1.000 21.59000 ? 233 PRO A CD  1 
ATOM   1428 N N   . PHE A 1 190 ? 63.98800 67.85300 -3.18700  1.000 22.56000 ? 234 PHE A N   1 
ATOM   1429 C CA  . PHE A 1 190 ? 64.06900 66.64900 -4.00800  1.000 22.46000 ? 234 PHE A CA  1 
ATOM   1430 C C   . PHE A 1 190 ? 62.95300 66.62600 -5.04500  1.000 24.07000 ? 234 PHE A C   1 
ATOM   1431 O O   . PHE A 1 190 ? 63.19400 66.36500 -6.22900  1.000 25.36000 ? 234 PHE A O   1 
ATOM   1432 C CB  . PHE A 1 190 ? 64.00700 65.39400 -3.13200  1.000 21.45000 ? 234 PHE A CB  1 
ATOM   1433 C CG  . PHE A 1 190 ? 65.09300 65.31200 -2.09600  1.000 21.51000 ? 234 PHE A CG  1 
ATOM   1434 C CD1 . PHE A 1 190 ? 66.29600 65.97700 -2.26600  1.000 20.90000 ? 234 PHE A CD1 1 
ATOM   1435 C CD2 . PHE A 1 190 ? 64.90400 64.56400 -0.94400  1.000 21.61000 ? 234 PHE A CD2 1 
ATOM   1436 C CE1 . PHE A 1 190 ? 67.28800 65.90000 -1.30600  1.000 21.86000 ? 234 PHE A CE1 1 
ATOM   1437 C CE2 . PHE A 1 190 ? 65.89000 64.48400 0.01800   1.000 19.17000 ? 234 PHE A CE2 1 
ATOM   1438 C CZ  . PHE A 1 190 ? 67.08400 65.15200 -0.16300  1.000 21.07000 ? 234 PHE A CZ  1 
ATOM   1439 N N   . TYR A 1 191 ? 61.72200 66.91300 -4.61500  1.000 22.28000 ? 235 TYR A N   1 
ATOM   1440 C CA  . TYR A 1 191 ? 60.58100 66.85300 -5.52300  1.000 24.03000 ? 235 TYR A CA  1 
ATOM   1441 C C   . TYR A 1 191 ? 60.68500 67.90900 -6.61700  1.000 24.15000 ? 235 TYR A C   1 
ATOM   1442 O O   . TYR A 1 191 ? 60.45400 67.62000 -7.79700  1.000 23.84000 ? 235 TYR A O   1 
ATOM   1443 C CB  . TYR A 1 191 ? 59.27700 67.01800 -4.74000  1.000 20.91000 ? 235 TYR A CB  1 
ATOM   1444 C CG  . TYR A 1 191 ? 58.05400 67.13300 -5.62200  1.000 19.28000 ? 235 TYR A CG  1 
ATOM   1445 C CD1 . TYR A 1 191 ? 57.41600 66.00100 -6.10500  1.000 17.41000 ? 235 TYR A CD1 1 
ATOM   1446 C CD2 . TYR A 1 191 ? 57.54100 68.37600 -5.97500  1.000 21.17000 ? 235 TYR A CD2 1 
ATOM   1447 C CE1 . TYR A 1 191 ? 56.30300 66.10100 -6.91300  1.000 20.35000 ? 235 TYR A CE1 1 
ATOM   1448 C CE2 . TYR A 1 191 ? 56.43000 68.48500 -6.78600  1.000 20.48000 ? 235 TYR A CE2 1 
ATOM   1449 C CZ  . TYR A 1 191 ? 55.81500 67.34400 -7.25100  1.000 19.32000 ? 235 TYR A CZ  1 
ATOM   1450 O OH  . TYR A 1 191 ? 54.70700 67.44800 -8.05700  1.000 20.84000 ? 235 TYR A OH  1 
ATOM   1451 N N   . GLU A 1 192 ? 61.02400 69.14400 -6.24200  1.000 22.29000 ? 236 GLU A N   1 
ATOM   1452 C CA  . GLU A 1 192 ? 61.09000 70.21900 -7.22500  1.000 24.71000 ? 236 GLU A CA  1 
ATOM   1453 C C   . GLU A 1 192 ? 62.23800 70.02100 -8.20600  1.000 26.83000 ? 236 GLU A C   1 
ATOM   1454 O O   . GLU A 1 192 ? 62.18700 70.53900 -9.32600  1.000 29.75000 ? 236 GLU A O   1 
ATOM   1455 C CB  . GLU A 1 192 ? 61.22200 71.56800 -6.52100  1.000 23.79000 ? 236 GLU A CB  1 
ATOM   1456 C CG  . GLU A 1 192 ? 60.01300 71.94400 -5.68200  1.000 25.66000 ? 236 GLU A CG  1 
ATOM   1457 C CD  . GLU A 1 192 ? 58.75900 72.11800 -6.51500  1.000 25.61000 ? 236 GLU A CD  1 
ATOM   1458 O OE1 . GLU A 1 192 ? 58.87500 72.53600 -7.68500  1.000 31.24000 ? 236 GLU A OE1 1 
ATOM   1459 O OE2 . GLU A 1 192 ? 57.65700 71.83200 -6.00200  1.000 27.29000 ? 236 GLU A OE2 1 
ATOM   1460 N N   . SER A 1 193 ? 63.27700 69.28600 -7.81000  1.000 26.35000 ? 237 SER A N   1 
ATOM   1461 C CA  . SER A 1 193 ? 64.38000 69.01500 -8.72100  1.000 24.78000 ? 237 SER A CA  1 
ATOM   1462 C C   . SER A 1 193 ? 64.10400 67.82300 -9.62400  1.000 26.35000 ? 237 SER A C   1 
ATOM   1463 O O   . SER A 1 193 ? 64.82200 67.63600 -10.61200 1.000 28.81000 ? 237 SER A O   1 
ATOM   1464 C CB  . SER A 1 193 ? 65.67300 68.77600 -7.94200  1.000 24.28000 ? 237 SER A CB  1 
ATOM   1465 O OG  . SER A 1 193 ? 65.67400 67.49400 -7.34200  1.000 26.99000 ? 237 SER A OG  1 
ATOM   1466 N N   . LEU A 1 194 ? 63.10200 67.01100 -9.29900  1.000 24.18000 ? 238 LEU A N   1 
ATOM   1467 C CA  . LEU A 1 194 ? 62.68400 65.95600 -10.20200 1.000 23.71000 ? 238 LEU A CA  1 
ATOM   1468 C C   . LEU A 1 194 ? 62.19200 66.57200 -11.51000 1.000 26.20000 ? 238 LEU A C   1 
ATOM   1469 O O   . LEU A 1 194 ? 61.69700 67.70400 -11.52300 1.000 27.57000 ? 238 LEU A O   1 
ATOM   1470 C CB  . LEU A 1 194 ? 61.57800 65.11300 -9.57300  1.000 22.63000 ? 238 LEU A CB  1 
ATOM   1471 C CG  . LEU A 1 194 ? 61.93900 64.22200 -8.38600  1.000 22.15000 ? 238 LEU A CG  1 
ATOM   1472 C CD1 . LEU A 1 194 ? 60.68400 63.55000 -7.86500  1.000 21.78000 ? 238 LEU A CD1 1 
ATOM   1473 C CD2 . LEU A 1 194 ? 62.98100 63.18600 -8.77500  1.000 20.52000 ? 238 LEU A CD2 1 
ATOM   1474 N N   . PRO A 1 195 ? 62.33300 65.85700 -12.62500 1.000 27.62000 ? 239 PRO A N   1 
ATOM   1475 C CA  . PRO A 1 195 ? 61.90900 66.41500 -13.91400 1.000 26.37000 ? 239 PRO A CA  1 
ATOM   1476 C C   . PRO A 1 195 ? 60.44400 66.82200 -13.89000 1.000 22.77000 ? 239 PRO A C   1 
ATOM   1477 O O   . PRO A 1 195 ? 59.59400 66.12100 -13.33800 1.000 26.26000 ? 239 PRO A O   1 
ATOM   1478 C CB  . PRO A 1 195 ? 62.16000 65.26600 -14.89400 1.000 23.86000 ? 239 PRO A CB  1 
ATOM   1479 C CG  . PRO A 1 195 ? 63.23100 64.46200 -14.25300 1.000 25.50000 ? 239 PRO A CG  1 
ATOM   1480 C CD  . PRO A 1 195 ? 62.97600 64.54200 -12.77700 1.000 24.49000 ? 239 PRO A CD  1 
ATOM   1481 N N   . SER A 1 196 ? 60.16100 67.98000 -14.49100 1.000 24.77000 ? 240 SER A N   1 
ATOM   1482 C CA  . SER A 1 196 ? 58.79600 68.48800 -14.52900 1.000 24.16000 ? 240 SER A CA  1 
ATOM   1483 C C   . SER A 1 196 ? 57.85400 67.53700 -15.25200 1.000 25.41000 ? 240 SER A C   1 
ATOM   1484 O O   . SER A 1 196 ? 56.64700 67.55400 -14.98900 1.000 25.48000 ? 240 SER A O   1 
ATOM   1485 C CB  . SER A 1 196 ? 58.76800 69.86100 -15.19900 1.000 32.15000 ? 240 SER A CB  1 
ATOM   1486 O OG  . SER A 1 196 ? 59.20900 69.78100 -16.54600 1.000 32.79000 ? 240 SER A OG  1 
ATOM   1487 N N   . SER A 1 197 ? 58.37900 66.70900 -16.14800 1.000 25.25000 ? 241 SER A N   1 
ATOM   1488 C CA  . SER A 1 197 ? 57.58200 65.74700 -16.89200 1.000 25.50000 ? 241 SER A CA  1 
ATOM   1489 C C   . SER A 1 197 ? 57.53000 64.38000 -16.22800 1.000 25.82000 ? 241 SER A C   1 
ATOM   1490 O O   . SER A 1 197 ? 56.83900 63.48900 -16.73200 1.000 25.40000 ? 241 SER A O   1 
ATOM   1491 C CB  . SER A 1 197 ? 58.13100 65.60700 -18.30900 1.000 27.22000 ? 241 SER A CB  1 
ATOM   1492 O OG  . SER A 1 197 ? 59.52800 65.38000 -18.28900 1.000 27.88000 ? 241 SER A OG  1 
ATOM   1493 N N   . LEU A 1 198 ? 58.23900 64.19200 -15.12300 1.000 26.87000 ? 242 LEU A N   1 
ATOM   1494 C CA  . LEU A 1 198 ? 58.20800 62.91300 -14.43500 1.000 23.49000 ? 242 LEU A CA  1 
ATOM   1495 C C   . LEU A 1 198 ? 56.86500 62.73000 -13.73300 1.000 21.02000 ? 242 LEU A C   1 
ATOM   1496 O O   . LEU A 1 198 ? 56.34300 63.67500 -13.13300 1.000 24.46000 ? 242 LEU A O   1 
ATOM   1497 C CB  . LEU A 1 198 ? 59.34700 62.82900 -13.42000 1.000 22.52000 ? 242 LEU A CB  1 
ATOM   1498 C CG  . LEU A 1 198 ? 59.53000 61.51300 -12.66400 1.000 21.86000 ? 242 LEU A CG  1 
ATOM   1499 C CD1 . LEU A 1 198 ? 60.06100 60.43900 -13.59500 1.000 22.39000 ? 242 LEU A CD1 1 
ATOM   1500 C CD2 . LEU A 1 198 ? 60.45900 61.71200 -11.48000 1.000 21.35000 ? 242 LEU A CD2 1 
ATOM   1501 N N   . PRO A 1 199 ? 56.26700 61.53900 -13.80900 1.000 21.23000 ? 243 PRO A N   1 
ATOM   1502 C CA  . PRO A 1 199 ? 55.07800 61.26500 -12.99100 1.000 22.29000 ? 243 PRO A CA  1 
ATOM   1503 C C   . PRO A 1 199 ? 55.43400 61.25900 -11.51400 1.000 22.64000 ? 243 PRO A C   1 
ATOM   1504 O O   . PRO A 1 199 ? 55.93500 60.25600 -10.99700 1.000 22.11000 ? 243 PRO A O   1 
ATOM   1505 C CB  . PRO A 1 199 ? 54.62400 59.87900 -13.47200 1.000 21.73000 ? 243 PRO A CB  1 
ATOM   1506 C CG  . PRO A 1 199 ? 55.28100 59.69100 -14.80500 1.000 24.34000 ? 243 PRO A CG  1 
ATOM   1507 C CD  . PRO A 1 199 ? 56.58000 60.42900 -14.72400 1.000 22.69000 ? 243 PRO A CD  1 
ATOM   1508 N N   . LYS A 1 200 ? 55.18900 62.37300 -10.82600 1.000 23.56000 ? 244 LYS A N   1 
ATOM   1509 C CA  . LYS A 1 200 ? 55.67800 62.55500 -9.46700  1.000 20.39000 ? 244 LYS A CA  1 
ATOM   1510 C C   . LYS A 1 200 ? 54.58900 63.16400 -8.59500  1.000 21.00000 ? 244 LYS A C   1 
ATOM   1511 O O   . LYS A 1 200 ? 53.62100 63.74900 -9.08700  1.000 19.84000 ? 244 LYS A O   1 
ATOM   1512 C CB  . LYS A 1 200 ? 56.92900 63.44100 -9.44500  1.000 16.94000 ? 244 LYS A CB  1 
ATOM   1513 C CG  . LYS A 1 200 ? 56.73000 64.79700 -10.09600 1.000 19.00000 ? 244 LYS A CG  1 
ATOM   1514 C CD  . LYS A 1 200 ? 57.99000 65.63700 -10.02500 1.000 18.72000 ? 244 LYS A CD  1 
ATOM   1515 C CE  . LYS A 1 200 ? 57.71400 67.06800 -10.44800 1.000 19.52000 ? 244 LYS A CE  1 
ATOM   1516 N NZ  . LYS A 1 200 ? 58.91900 67.92600 -10.31000 1.000 21.43000 ? 244 LYS A NZ  1 
ATOM   1517 N N   . ALA A 1 201 ? 54.76800 63.02100 -7.28300  1.000 20.82000 ? 245 ALA A N   1 
ATOM   1518 C CA  . ALA A 1 201 ? 53.84400 63.58200 -6.31000  1.000 19.03000 ? 245 ALA A CA  1 
ATOM   1519 C C   . ALA A 1 201 ? 54.58500 63.83200 -5.00500  1.000 18.98000 ? 245 ALA A C   1 
ATOM   1520 O O   . ALA A 1 201 ? 55.55900 63.14500 -4.68500  1.000 18.14000 ? 245 ALA A O   1 
ATOM   1521 C CB  . ALA A 1 201 ? 52.64100 62.66200 -6.07300  1.000 17.94000 ? 245 ALA A CB  1 
ATOM   1522 N N   . TYR A 1 202 ? 54.11800 64.83100 -4.25800  1.000 21.78000 ? 246 TYR A N   1 
ATOM   1523 C CA  . TYR A 1 202 ? 54.66500 65.16400 -2.94800  1.000 20.09000 ? 246 TYR A CA  1 
ATOM   1524 C C   . TYR A 1 202 ? 53.51200 65.33500 -1.97400  1.000 18.17000 ? 246 TYR A C   1 
ATOM   1525 O O   . TYR A 1 202 ? 52.64400 66.18600 -2.18400  1.000 19.58000 ? 246 TYR A O   1 
ATOM   1526 C CB  . TYR A 1 202 ? 55.51500 66.43600 -3.00100  1.000 20.13000 ? 246 TYR A CB  1 
ATOM   1527 C CG  . TYR A 1 202 ? 55.88700 66.97500 -1.63700  1.000 21.23000 ? 246 TYR A CG  1 
ATOM   1528 C CD1 . TYR A 1 202 ? 56.78900 66.30100 -0.82500  1.000 19.78000 ? 246 TYR A CD1 1 
ATOM   1529 C CD2 . TYR A 1 202 ? 55.33900 68.16200 -1.16400  1.000 21.87000 ? 246 TYR A CD2 1 
ATOM   1530 C CE1 . TYR A 1 202 ? 57.13200 66.78900 0.42100   1.000 21.85000 ? 246 TYR A CE1 1 
ATOM   1531 C CE2 . TYR A 1 202 ? 55.67800 68.65800 0.08200   1.000 20.95000 ? 246 TYR A CE2 1 
ATOM   1532 C CZ  . TYR A 1 202 ? 56.57500 67.96800 0.86900   1.000 20.95000 ? 246 TYR A CZ  1 
ATOM   1533 O OH  . TYR A 1 202 ? 56.91500 68.45800 2.10900   1.000 22.60000 ? 246 TYR A OH  1 
ATOM   1534 N N   . MET A 1 203 ? 53.50300 64.52900 -0.91600  1.000 19.15000 ? 247 MET A N   1 
ATOM   1535 C CA  . MET A 1 203 ? 52.46200 64.58000 0.10300   1.000 19.52000 ? 247 MET A CA  1 
ATOM   1536 C C   . MET A 1 203 ? 53.10000 64.91800 1.44100   1.000 20.54000 ? 247 MET A C   1 
ATOM   1537 O O   . MET A 1 203 ? 53.94700 64.16600 1.93600   1.000 21.12000 ? 247 MET A O   1 
ATOM   1538 C CB  . MET A 1 203 ? 51.70600 63.25400 0.18900   1.000 19.04000 ? 247 MET A CB  1 
ATOM   1539 C CG  . MET A 1 203 ? 50.62100 63.23900 1.25400   1.000 18.37000 ? 247 MET A CG  1 
ATOM   1540 S SD  . MET A 1 203 ? 49.72300 61.68100 1.34000   1.000 19.93000 ? 247 MET A SD  1 
ATOM   1541 C CE  . MET A 1 203 ? 51.00800 60.56700 1.89300   1.000 17.85000 ? 247 MET A CE  1 
ATOM   1542 N N   . GLU A 1 204 ? 52.69400 66.04100 2.02100   1.000 20.05000 ? 248 GLU A N   1 
ATOM   1543 C CA  . GLU A 1 204 ? 53.17800 66.46500 3.32500   1.000 21.35000 ? 248 GLU A CA  1 
ATOM   1544 C C   . GLU A 1 204 ? 52.11100 66.18800 4.37600   1.000 19.28000 ? 248 GLU A C   1 
ATOM   1545 O O   . GLU A 1 204 ? 50.96600 66.63300 4.23900   1.000 18.81000 ? 248 GLU A O   1 
ATOM   1546 C CB  . GLU A 1 204 ? 53.54800 67.94800 3.31500   1.000 20.53000 ? 248 GLU A CB  1 
ATOM   1547 C CG  . GLU A 1 204 ? 54.10900 68.43300 4.63400   1.000 20.98000 ? 248 GLU A CG  1 
ATOM   1548 C CD  . GLU A 1 204 ? 54.75400 69.79400 4.53800   1.000 23.89000 ? 248 GLU A CD  1 
ATOM   1549 O OE1 . GLU A 1 204 ? 55.33700 70.11200 3.47900   1.000 28.02000 ? 248 GLU A OE1 1 
ATOM   1550 O OE2 . GLU A 1 204 ? 54.68200 70.55100 5.52800   1.000 25.80000 ? 248 GLU A OE2 1 
ATOM   1551 N N   . LEU A 1 205 ? 52.48900 65.45400 5.41900   1.000 22.68000 ? 249 LEU A N   1 
ATOM   1552 C CA  . LEU A 1 205 ? 51.56200 65.05700 6.47100   1.000 21.62000 ? 249 LEU A CA  1 
ATOM   1553 C C   . LEU A 1 205 ? 51.52600 66.11800 7.56500   1.000 21.61000 ? 249 LEU A C   1 
ATOM   1554 O O   . LEU A 1 205 ? 52.57600 66.55500 8.04900   1.000 21.94000 ? 249 LEU A O   1 
ATOM   1555 C CB  . LEU A 1 205 ? 51.96900 63.70400 7.05400   1.000 21.26000 ? 249 LEU A CB  1 
ATOM   1556 C CG  . LEU A 1 205 ? 52.11600 62.58000 6.02800   1.000 20.29000 ? 249 LEU A CG  1 
ATOM   1557 C CD1 . LEU A 1 205 ? 52.76200 61.35200 6.64900   1.000 20.69000 ? 249 LEU A CD1 1 
ATOM   1558 C CD2 . LEU A 1 205 ? 50.76400 62.23300 5.43000   1.000 19.99000 ? 249 LEU A CD2 1 
ATOM   1559 N N   . CYS A 1 206 ? 50.31600 66.52500 7.94900   1.000 22.81000 ? 250 CYS A N   1 
ATOM   1560 C CA  . CYS A 1 206 ? 50.15100 67.56300 8.96000   1.000 24.95000 ? 250 CYS A CA  1 
ATOM   1561 C C   . CYS A 1 206 ? 50.72200 67.11900 10.30100  1.000 23.32000 ? 250 CYS A C   1 
ATOM   1562 O O   . CYS A 1 206 ? 50.42500 66.02300 10.78500  1.000 24.65000 ? 250 CYS A O   1 
ATOM   1563 C CB  . CYS A 1 206 ? 48.67300 67.91500 9.12800   1.000 24.01000 ? 250 CYS A CB  1 
ATOM   1564 S SG  . CYS A 1 206 ? 47.91400 68.85900 7.78900   1.000 27.51000 ? 250 CYS A SG  1 
ATOM   1565 N N   . GLY A 1 207 ? 51.54100 67.98200 10.90000  1.000 24.75000 ? 251 GLY A N   1 
ATOM   1566 C CA  . GLY A 1 207 ? 52.03200 67.78300 12.25000  1.000 22.99000 ? 251 GLY A CA  1 
ATOM   1567 C C   . GLY A 1 207 ? 52.83400 66.52000 12.48800  1.000 25.87000 ? 251 GLY A C   1 
ATOM   1568 O O   . GLY A 1 207 ? 53.07700 66.14700 13.64000  1.000 27.20000 ? 251 GLY A O   1 
ATOM   1569 N N   . ALA A 1 208 ? 53.25700 65.85400 11.41700  1.000 25.40000 ? 252 ALA A N   1 
ATOM   1570 C CA  . ALA A 1 208 ? 54.00200 64.61400 11.55900  1.000 20.08000 ? 252 ALA A CA  1 
ATOM   1571 C C   . ALA A 1 208 ? 55.47400 64.89700 11.84700  1.000 19.70000 ? 252 ALA A C   1 
ATOM   1572 O O   . ALA A 1 208 ? 55.99700 65.97800 11.56600  1.000 21.84000 ? 252 ALA A O   1 
ATOM   1573 C CB  . ALA A 1 208 ? 53.86800 63.75600 10.30000  1.000 22.53000 ? 252 ALA A CB  1 
ATOM   1574 N N   . THR A 1 209 ? 56.14000 63.90200 12.42200  1.000 21.85000 ? 253 THR A N   1 
ATOM   1575 C CA  . THR A 1 209 ? 57.54900 63.98300 12.76900  1.000 20.41000 ? 253 THR A CA  1 
ATOM   1576 C C   . THR A 1 209 ? 58.35200 63.02200 11.89400  1.000 21.06000 ? 253 THR A C   1 
ATOM   1577 O O   . THR A 1 209 ? 57.81600 62.34600 11.01200  1.000 21.97000 ? 253 THR A O   1 
ATOM   1578 C CB  . THR A 1 209 ? 57.75900 63.68300 14.25600  1.000 24.73000 ? 253 THR A CB  1 
ATOM   1579 O OG1 . THR A 1 209 ? 57.48200 62.30100 14.51500  1.000 28.93000 ? 253 THR A OG1 1 
ATOM   1580 C CG2 . THR A 1 209 ? 56.83800 64.54500 15.10300  1.000 26.49000 ? 253 THR A CG2 1 
ATOM   1581 N N   . HIS A 1 210 ? 59.65700 62.95700 12.16800  1.000 21.64000 ? 254 HIS A N   1 
ATOM   1582 C CA  . HIS A 1 210 ? 60.57600 62.23400 11.29400  1.000 21.39000 ? 254 HIS A CA  1 
ATOM   1583 C C   . HIS A 1 210 ? 60.29700 60.73600 11.26500  1.000 22.01000 ? 254 HIS A C   1 
ATOM   1584 O O   . HIS A 1 210 ? 60.52300 60.08800 10.23700  1.000 20.22000 ? 254 HIS A O   1 
ATOM   1585 C CB  . HIS A 1 210 ? 62.01500 62.48500 11.73800  1.000 21.27000 ? 254 HIS A CB  1 
ATOM   1586 C CG  . HIS A 1 210 ? 63.03900 61.87000 10.83900  1.000 22.57000 ? 254 HIS A CG  1 
ATOM   1587 N ND1 . HIS A 1 210 ? 63.16400 62.21600 9.51100   1.000 21.75000 ? 254 HIS A ND1 1 
ATOM   1588 C CD2 . HIS A 1 210 ? 63.98700 60.93200 11.07500  1.000 22.07000 ? 254 HIS A CD2 1 
ATOM   1589 C CE1 . HIS A 1 210 ? 64.14600 61.52000 8.96800   1.000 21.87000 ? 254 HIS A CE1 1 
ATOM   1590 N NE2 . HIS A 1 210 ? 64.66100 60.73300 9.89500   1.000 23.60000 ? 254 HIS A NE2 1 
ATOM   1591 N N   . PHE A 1 211 ? 59.81900 60.16700 12.37000  1.000 20.69000 ? 255 PHE A N   1 
ATOM   1592 C CA  . PHE A 1 211 ? 59.62500 58.72900 12.47400  1.000 18.12000 ? 255 PHE A CA  1 
ATOM   1593 C C   . PHE A 1 211 ? 58.16600 58.32100 12.30400  1.000 17.66000 ? 255 PHE A C   1 
ATOM   1594 O O   . PHE A 1 211 ? 57.79200 57.20800 12.68300  1.000 20.41000 ? 255 PHE A O   1 
ATOM   1595 C CB  . PHE A 1 211 ? 60.18500 58.22700 13.80500  1.000 20.84000 ? 255 PHE A CB  1 
ATOM   1596 C CG  . PHE A 1 211 ? 61.61600 58.62700 14.03700  1.000 19.66000 ? 255 PHE A CG  1 
ATOM   1597 C CD1 . PHE A 1 211 ? 62.65300 57.87300 13.51400  1.000 19.51000 ? 255 PHE A CD1 1 
ATOM   1598 C CD2 . PHE A 1 211 ? 61.92300 59.77000 14.75600  1.000 20.16000 ? 255 PHE A CD2 1 
ATOM   1599 C CE1 . PHE A 1 211 ? 63.97000 58.24500 13.71500  1.000 20.04000 ? 255 PHE A CE1 1 
ATOM   1600 C CE2 . PHE A 1 211 ? 63.23700 60.14700 14.96000  1.000 21.93000 ? 255 PHE A CE2 1 
ATOM   1601 C CZ  . PHE A 1 211 ? 64.26200 59.38400 14.43800  1.000 20.30000 ? 255 PHE A CZ  1 
ATOM   1602 N N   . ALA A 1 212 ? 57.33900 59.19800 11.73600  1.000 18.50000 ? 256 ALA A N   1 
ATOM   1603 C CA  . ALA A 1 212 ? 55.95900 58.82400 11.44100  1.000 19.21000 ? 256 ALA A CA  1 
ATOM   1604 C C   . ALA A 1 212 ? 55.83500 57.66000 10.46200  1.000 18.88000 ? 256 ALA A C   1 
ATOM   1605 O O   . ALA A 1 212 ? 54.90500 56.85200 10.62900  1.000 19.42000 ? 256 ALA A O   1 
ATOM   1606 C CB  . ALA A 1 212 ? 55.18800 60.04700 10.92800  1.000 19.81000 ? 256 ALA A CB  1 
ATOM   1607 N N   . PRO A 1 213 ? 56.68700 57.51000 9.43800   1.000 19.55000 ? 257 PRO A N   1 
ATOM   1608 C CA  . PRO A 1 213 ? 56.57300 56.32500 8.56900   1.000 20.05000 ? 257 PRO A CA  1 
ATOM   1609 C C   . PRO A 1 213 ? 56.89200 55.00800 9.25900   1.000 20.15000 ? 257 PRO A C   1 
ATOM   1610 O O   . PRO A 1 213 ? 56.70700 53.95300 8.63800   1.000 21.66000 ? 257 PRO A O   1 
ATOM   1611 C CB  . PRO A 1 213 ? 57.58300 56.61300 7.45000   1.000 18.29000 ? 257 PRO A CB  1 
ATOM   1612 C CG  . PRO A 1 213 ? 57.70100 58.08600 7.42500   1.000 18.60000 ? 257 PRO A CG  1 
ATOM   1613 C CD  . PRO A 1 213 ? 57.61200 58.50300 8.85800   1.000 20.42000 ? 257 PRO A CD  1 
ATOM   1614 N N   . ASN A 1 214 ? 57.35700 55.02100 10.50700  1.000 20.71000 ? 258 ASN A N   1 
ATOM   1615 C CA  . ASN A 1 214 ? 57.74300 53.78900 11.18300  1.000 19.68000 ? 258 ASN A CA  1 
ATOM   1616 C C   . ASN A 1 214 ? 56.60100 53.13400 11.94600  1.000 17.66000 ? 258 ASN A C   1 
ATOM   1617 O O   . ASN A 1 214 ? 56.78000 52.02600 12.46300  1.000 19.97000 ? 258 ASN A O   1 
ATOM   1618 C CB  . ASN A 1 214 ? 58.90900 54.05700 12.13700  1.000 19.14000 ? 258 ASN A CB  1 
ATOM   1619 C CG  . ASN A 1 214 ? 60.13600 54.56900 11.41900  1.000 18.37000 ? 258 ASN A CG  1 
ATOM   1620 O OD1 . ASN A 1 214 ? 60.75000 55.54700 11.83800  1.000 20.60000 ? 258 ASN A OD1 1 
ATOM   1621 N ND2 . ASN A 1 214 ? 60.49300 53.91600 10.32000  1.000 20.78000 ? 258 ASN A ND2 1 
ATOM   1622 N N   . ILE A 1 215 ? 55.44300 53.78100 12.03000  1.000 18.89000 ? 259 ILE A N   1 
ATOM   1623 C CA  . ILE A 1 215 ? 54.27300 53.20000 12.68500  1.000 20.19000 ? 259 ILE A CA  1 
ATOM   1624 C C   . ILE A 1 215 ? 53.11200 53.22800 11.70100  1.000 20.48000 ? 259 ILE A C   1 
ATOM   1625 O O   . ILE A 1 215 ? 53.11300 54.01900 10.74400  1.000 21.24000 ? 259 ILE A O   1 
ATOM   1626 C CB  . ILE A 1 215 ? 53.91800 53.95000 13.99100  1.000 22.75000 ? 259 ILE A CB  1 
ATOM   1627 C CG1 . ILE A 1 215 ? 53.73200 55.44300 13.72200  1.000 21.05000 ? 259 ILE A CG1 1 
ATOM   1628 C CG2 . ILE A 1 215 ? 54.98400 53.71600 15.04900  1.000 23.86000 ? 259 ILE A CG2 1 
ATOM   1629 C CD1 . ILE A 1 215 ? 53.31200 56.23200 14.94000  1.000 24.12000 ? 259 ILE A CD1 1 
ATOM   1630 N N   . PRO A 1 216 ? 52.11500 52.36400 11.89700  1.000 19.35000 ? 260 PRO A N   1 
ATOM   1631 C CA  . PRO A 1 216 ? 50.96600 52.33300 10.98400  1.000 19.67000 ? 260 PRO A CA  1 
ATOM   1632 C C   . PRO A 1 216 ? 50.32900 53.70100 10.79400  1.000 21.34000 ? 260 PRO A C   1 
ATOM   1633 O O   . PRO A 1 216 ? 50.01000 54.40400 11.75600  1.000 24.03000 ? 260 PRO A O   1 
ATOM   1634 C CB  . PRO A 1 216 ? 50.00800 51.35500 11.66900  1.000 19.99000 ? 260 PRO A CB  1 
ATOM   1635 C CG  . PRO A 1 216 ? 50.90900 50.41600 12.37500  1.000 20.61000 ? 260 PRO A CG  1 
ATOM   1636 C CD  . PRO A 1 216 ? 52.07300 51.24500 12.85700  1.000 20.13000 ? 260 PRO A CD  1 
ATOM   1637 N N   . ASN A 1 217 ? 50.14700 54.07500 9.52900   1.000 21.99000 ? 261 ASN A N   1 
ATOM   1638 C CA  . ASN A 1 217 ? 49.57700 55.36200 9.15200   1.000 19.72000 ? 261 ASN A CA  1 
ATOM   1639 C C   . ASN A 1 217 ? 48.65500 55.13300 7.96600   1.000 21.85000 ? 261 ASN A C   1 
ATOM   1640 O O   . ASN A 1 217 ? 49.11300 54.72100 6.89700   1.000 22.69000 ? 261 ASN A O   1 
ATOM   1641 C CB  . ASN A 1 217 ? 50.67600 56.36800 8.80100   1.000 18.72000 ? 261 ASN A CB  1 
ATOM   1642 C CG  . ASN A 1 217 ? 50.14000 57.76800 8.58100   1.000 20.58000 ? 261 ASN A CG  1 
ATOM   1643 O OD1 . ASN A 1 217 ? 49.47300 58.04000 7.58400   1.000 22.75000 ? 261 ASN A OD1 1 
ATOM   1644 N ND2 . ASN A 1 217 ? 50.44500 58.67000 9.50500   1.000 19.93000 ? 261 ASN A ND2 1 
ATOM   1645 N N   . THR A 1 218 ? 47.36100 55.39400 8.15800   1.000 22.11000 ? 262 THR A N   1 
ATOM   1646 C CA  . THR A 1 218 ? 46.38700 55.13500 7.10200   1.000 21.60000 ? 262 THR A CA  1 
ATOM   1647 C C   . THR A 1 218 ? 46.62200 56.03500 5.89400   1.000 23.31000 ? 262 THR A C   1 
ATOM   1648 O O   . THR A 1 218 ? 46.48900 55.59100 4.74700   1.000 20.76000 ? 262 THR A O   1 
ATOM   1649 C CB  . THR A 1 218 ? 44.97000 55.31400 7.64800   1.000 21.89000 ? 262 THR A CB  1 
ATOM   1650 O OG1 . THR A 1 218 ? 44.72800 54.34800 8.67600   1.000 25.43000 ? 262 THR A OG1 1 
ATOM   1651 C CG2 . THR A 1 218 ? 43.94300 55.13400 6.54700   1.000 23.62000 ? 262 THR A CG2 1 
ATOM   1652 N N   . THR A 1 219 ? 46.97600 57.30100 6.13000   1.000 21.56000 ? 263 THR A N   1 
ATOM   1653 C CA  . THR A 1 219 ? 47.23700 58.21300 5.02100   1.000 20.45000 ? 263 THR A CA  1 
ATOM   1654 C C   . THR A 1 219 ? 48.43600 57.75300 4.20200   1.000 22.09000 ? 263 THR A C   1 
ATOM   1655 O O   . THR A 1 219 ? 48.40200 57.78200 2.96600   1.000 22.96000 ? 263 THR A O   1 
ATOM   1656 C CB  . THR A 1 219 ? 47.45500 59.63100 5.54700   1.000 19.60000 ? 263 THR A CB  1 
ATOM   1657 O OG1 . THR A 1 219 ? 46.33000 60.02200 6.34300   1.000 22.68000 ? 263 THR A OG1 1 
ATOM   1658 C CG2 . THR A 1 219 ? 47.61600 60.61100 4.39500   1.000 22.24000 ? 263 THR A CG2 1 
ATOM   1659 N N   . ILE A 1 220 ? 49.50500 57.32000 4.87200   1.000 19.62000 ? 264 ILE A N   1 
ATOM   1660 C CA  . ILE A 1 220 ? 50.64100 56.74900 4.15800   1.000 19.35000 ? 264 ILE A CA  1 
ATOM   1661 C C   . ILE A 1 220 ? 50.22800 55.47400 3.43700   1.000 21.72000 ? 264 ILE A C   1 
ATOM   1662 O O   . ILE A 1 220 ? 50.58900 55.25700 2.27400   1.000 22.37000 ? 264 ILE A O   1 
ATOM   1663 C CB  . ILE A 1 220 ? 51.81200 56.49400 5.12500   1.000 16.95000 ? 264 ILE A CB  1 
ATOM   1664 C CG1 . ILE A 1 220 ? 52.30700 57.81100 5.71900   1.000 17.90000 ? 264 ILE A CG1 1 
ATOM   1665 C CG2 . ILE A 1 220 ? 52.94600 55.76600 4.41800   1.000 16.93000 ? 264 ILE A CG2 1 
ATOM   1666 C CD1 . ILE A 1 220 ? 53.49000 57.64900 6.63600   1.000 17.28000 ? 264 ILE A CD1 1 
ATOM   1667 N N   . ALA A 1 221 ? 49.45100 54.62100 4.10600   1.000 21.42000 ? 265 ALA A N   1 
ATOM   1668 C CA  . ALA A 1 221 ? 49.14000 53.31100 3.54300   1.000 21.04000 ? 265 ALA A CA  1 
ATOM   1669 C C   . ALA A 1 221 ? 48.26400 53.42700 2.30200   1.000 20.96000 ? 265 ALA A C   1 
ATOM   1670 O O   . ALA A 1 221 ? 48.49700 52.73200 1.30700   1.000 23.36000 ? 265 ALA A O   1 
ATOM   1671 C CB  . ALA A 1 221 ? 48.46200 52.43500 4.59700   1.000 20.60000 ? 265 ALA A CB  1 
ATOM   1672 N N   . LYS A 1 222 ? 47.25700 54.30200 2.33800   1.000 20.64000 ? 266 LYS A N   1 
ATOM   1673 C CA  . LYS A 1 222 ? 46.28500 54.34600 1.25200   1.000 20.22000 ? 266 LYS A CA  1 
ATOM   1674 C C   . LYS A 1 222 ? 46.90300 54.83500 -0.05300  1.000 21.04000 ? 266 LYS A C   1 
ATOM   1675 O O   . LYS A 1 222 ? 46.50900 54.37400 -1.13000  1.000 21.74000 ? 266 LYS A O   1 
ATOM   1676 C CB  . LYS A 1 222 ? 45.09900 55.22800 1.64700   1.000 19.21000 ? 266 LYS A CB  1 
ATOM   1677 C CG  . LYS A 1 222 ? 45.45400 56.68400 1.89100   1.000 18.41000 ? 266 LYS A CG  1 
ATOM   1678 C CD  . LYS A 1 222 ? 44.25500 57.45900 2.39700   1.000 20.84000 ? 266 LYS A CD  1 
ATOM   1679 C CE  . LYS A 1 222 ? 43.10600 57.40100 1.40700   1.000 22.32000 ? 266 LYS A CE  1 
ATOM   1680 N NZ  . LYS A 1 222 ? 41.92800 58.17400 1.88400   1.000 23.86000 ? 266 LYS A NZ  1 
ATOM   1681 N N   . TYR A 1 223 ? 47.87400 55.74600 0.01800   1.000 22.03000 ? 267 TYR A N   1 
ATOM   1682 C CA  . TYR A 1 223 ? 48.47500 56.32000 -1.17800  1.000 20.44000 ? 267 TYR A CA  1 
ATOM   1683 C C   . TYR A 1 223 ? 49.79900 55.67400 -1.56400  1.000 21.27000 ? 267 TYR A C   1 
ATOM   1684 O O   . TYR A 1 223 ? 50.22700 55.82600 -2.71300  1.000 23.15000 ? 267 TYR A O   1 
ATOM   1685 C CB  . TYR A 1 223 ? 48.65900 57.83100 -0.99400  1.000 18.85000 ? 267 TYR A CB  1 
ATOM   1686 C CG  . TYR A 1 223 ? 47.33600 58.54300 -0.82100  1.000 21.86000 ? 267 TYR A CG  1 
ATOM   1687 C CD1 . TYR A 1 223 ? 46.27000 58.26600 -1.66700  1.000 20.15000 ? 267 TYR A CD1 1 
ATOM   1688 C CD2 . TYR A 1 223 ? 47.13800 59.45900 0.20400   1.000 20.32000 ? 267 TYR A CD2 1 
ATOM   1689 C CE1 . TYR A 1 223 ? 45.05300 58.89500 -1.51400  1.000 20.29000 ? 267 TYR A CE1 1 
ATOM   1690 C CE2 . TYR A 1 223 ? 45.91900 60.09500 0.36700   1.000 20.75000 ? 267 TYR A CE2 1 
ATOM   1691 C CZ  . TYR A 1 223 ? 44.88100 59.80600 -0.49700  1.000 22.42000 ? 267 TYR A CZ  1 
ATOM   1692 O OH  . TYR A 1 223 ? 43.66200 60.42900 -0.34800  1.000 23.53000 ? 267 TYR A OH  1 
ATOM   1693 N N   . VAL A 1 224 ? 50.45400 54.95900 -0.64700  1.000 20.36000 ? 268 VAL A N   1 
ATOM   1694 C CA  . VAL A 1 224 ? 51.56400 54.10100 -1.05100  1.000 20.57000 ? 268 VAL A CA  1 
ATOM   1695 C C   . VAL A 1 224 ? 51.04000 52.92000 -1.85800  1.000 22.62000 ? 268 VAL A C   1 
ATOM   1696 O O   . VAL A 1 224 ? 51.63500 52.52200 -2.86700  1.000 22.59000 ? 268 VAL A O   1 
ATOM   1697 C CB  . VAL A 1 224 ? 52.37100 53.64500 0.18000   1.000 19.02000 ? 268 VAL A CB  1 
ATOM   1698 C CG1 . VAL A 1 224 ? 53.20000 52.41100 -0.14100  1.000 20.33000 ? 268 VAL A CG1 1 
ATOM   1699 C CG2 . VAL A 1 224 ? 53.27500 54.77000 0.66100   1.000 19.08000 ? 268 VAL A CG2 1 
ATOM   1700 N N   . ILE A 1 225 ? 49.90100 52.36100 -1.44200  1.000 20.30000 ? 269 ILE A N   1 
ATOM   1701 C CA  . ILE A 1 225 ? 49.27000 51.28400 -2.19800  1.000 20.71000 ? 269 ILE A CA  1 
ATOM   1702 C C   . ILE A 1 225 ? 48.81700 51.78000 -3.56700  1.000 22.88000 ? 269 ILE A C   1 
ATOM   1703 O O   . ILE A 1 225 ? 49.02600 51.10900 -4.58400  1.000 22.82000 ? 269 ILE A O   1 
ATOM   1704 C CB  . ILE A 1 225 ? 48.10000 50.68900 -1.39300  1.000 23.38000 ? 269 ILE A CB  1 
ATOM   1705 C CG1 . ILE A 1 225 ? 48.62300 49.95600 -0.15700  1.000 22.32000 ? 269 ILE A CG1 1 
ATOM   1706 C CG2 . ILE A 1 225 ? 47.27100 49.75500 -2.25400  1.000 22.13000 ? 269 ILE A CG2 1 
ATOM   1707 C CD1 . ILE A 1 225 ? 47.53800 49.58300 0.81700   1.000 24.74000 ? 269 ILE A CD1 1 
ATOM   1708 N N   . SER A 1 226 ? 48.19400 52.96100 -3.61800  1.000 22.37000 ? 270 SER A N   1 
ATOM   1709 C CA  . SER A 1 226 ? 47.70400 53.48000 -4.89300  1.000 22.64000 ? 270 SER A CA  1 
ATOM   1710 C C   . SER A 1 226 ? 48.85200 53.77000 -5.85300  1.000 22.42000 ? 270 SER A C   1 
ATOM   1711 O O   . SER A 1 226 ? 48.73100 53.54300 -7.06300  1.000 21.97000 ? 270 SER A O   1 
ATOM   1712 C CB  . SER A 1 226 ? 46.87200 54.74200 -4.66900  1.000 18.91000 ? 270 SER A CB  1 
ATOM   1713 O OG  . SER A 1 226 ? 45.75300 54.48300 -3.84200  1.000 20.38000 ? 270 SER A OG  1 
ATOM   1714 N N   . TRP A 1 227 ? 49.97300 54.27400 -5.33200  1.000 23.53000 ? 271 TRP A N   1 
ATOM   1715 C CA  . TRP A 1 227 ? 51.11100 54.59100 -6.18900  1.000 21.94000 ? 271 TRP A CA  1 
ATOM   1716 C C   . TRP A 1 227 ? 51.74600 53.32700 -6.75400  1.000 24.40000 ? 271 TRP A C   1 
ATOM   1717 O O   . TRP A 1 227 ? 52.13300 53.29100 -7.92800  1.000 24.83000 ? 271 TRP A O   1 
ATOM   1718 C CB  . TRP A 1 227 ? 52.14500 55.40600 -5.41300  1.000 20.94000 ? 271 TRP A CB  1 
ATOM   1719 C CG  . TRP A 1 227 ? 53.18600 56.04700 -6.28100  1.000 19.94000 ? 271 TRP A CG  1 
ATOM   1720 C CD1 . TRP A 1 227 ? 54.41700 55.54700 -6.59800  1.000 18.57000 ? 271 TRP A CD1 1 
ATOM   1721 C CD2 . TRP A 1 227 ? 53.08600 57.31300 -6.94200  1.000 19.14000 ? 271 TRP A CD2 1 
ATOM   1722 N NE1 . TRP A 1 227 ? 55.08800 56.42500 -7.41500  1.000 18.90000 ? 271 TRP A NE1 1 
ATOM   1723 C CE2 . TRP A 1 227 ? 54.29200 57.51700 -7.64100  1.000 20.17000 ? 271 TRP A CE2 1 
ATOM   1724 C CE3 . TRP A 1 227 ? 52.09300 58.29500 -7.00900  1.000 17.43000 ? 271 TRP A CE3 1 
ATOM   1725 C CZ2 . TRP A 1 227 ? 54.53100 58.66300 -8.39700  1.000 19.60000 ? 271 TRP A CZ2 1 
ATOM   1726 C CZ3 . TRP A 1 227 ? 52.33100 59.43000 -7.75900  1.000 18.99000 ? 271 TRP A CZ3 1 
ATOM   1727 C CH2 . TRP A 1 227 ? 53.53900 59.60500 -8.44400  1.000 18.22000 ? 271 TRP A CH2 1 
ATOM   1728 N N   . LEU A 1 228 ? 51.86800 52.28400 -5.93100  1.000 22.95000 ? 272 LEU A N   1 
ATOM   1729 C CA  . LEU A 1 228 ? 52.39400 51.01600 -6.42300  1.000 23.69000 ? 272 LEU A CA  1 
ATOM   1730 C C   . LEU A 1 228 ? 51.44400 50.38000 -7.42900  1.000 23.83000 ? 272 LEU A C   1 
ATOM   1731 O O   . LEU A 1 228 ? 51.88300 49.83700 -8.44800  1.000 23.88000 ? 272 LEU A O   1 
ATOM   1732 C CB  . LEU A 1 228 ? 52.65500 50.06500 -5.25600  1.000 22.83000 ? 272 LEU A CB  1 
ATOM   1733 C CG  . LEU A 1 228 ? 53.75200 50.47900 -4.27400  1.000 20.54000 ? 272 LEU A CG  1 
ATOM   1734 C CD1 . LEU A 1 228 ? 53.85500 49.48300 -3.13100  1.000 21.77000 ? 272 LEU A CD1 1 
ATOM   1735 C CD2 . LEU A 1 228 ? 55.08400 50.61700 -4.99200  1.000 22.90000 ? 272 LEU A CD2 1 
ATOM   1736 N N   . LYS A 1 229 ? 50.13800 50.43800 -7.16500  1.000 23.29000 ? 273 LYS A N   1 
ATOM   1737 C CA  . LYS A 1 229 ? 49.17400 49.86000 -8.09500  1.000 26.02000 ? 273 LYS A CA  1 
ATOM   1738 C C   . LYS A 1 229 ? 49.21500 50.56400 -9.44500  1.000 25.36000 ? 273 LYS A C   1 
ATOM   1739 O O   . LYS A 1 229 ? 49.14100 49.91400 -10.49400 1.000 26.90000 ? 273 LYS A O   1 
ATOM   1740 C CB  . LYS A 1 229 ? 47.76700 49.93100 -7.50300  1.000 24.09000 ? 273 LYS A CB  1 
ATOM   1741 C CG  . LYS A 1 229 ? 47.46800 48.88400 -6.44700  1.000 24.41000 ? 273 LYS A CG  1 
ATOM   1742 C CD  . LYS A 1 229 ? 47.25600 47.51600 -7.06800  1.000 26.88000 ? 273 LYS A CD  1 
ATOM   1743 C CE  . LYS A 1 229 ? 46.61500 46.56400 -6.07700  1.000 27.83000 ? 273 LYS A CE  1 
ATOM   1744 N NZ  . LYS A 1 229 ? 46.35500 45.22500 -6.67300  1.000 29.07000 ? 273 LYS A NZ  1 
ATOM   1745 N N   . ARG A 1 230 ? 49.34500 51.89100 -9.43900  1.000 24.45000 ? 274 ARG A N   1 
ATOM   1746 C CA  . ARG A 1 230 ? 49.25200 52.64800 -10.68400 1.000 25.27000 ? 274 ARG A CA  1 
ATOM   1747 C C   . ARG A 1 230 ? 50.47400 52.43400 -11.56900 1.000 24.97000 ? 274 ARG A C   1 
ATOM   1748 O O   . ARG A 1 230 ? 50.34800 52.36000 -12.79600 1.000 25.12000 ? 274 ARG A O   1 
ATOM   1749 C CB  . ARG A 1 230 ? 49.05800 54.13400 -10.37400 1.000 23.52000 ? 274 ARG A CB  1 
ATOM   1750 C CG  . ARG A 1 230 ? 49.15800 55.05600 -11.58300 1.000 25.81000 ? 274 ARG A CG  1 
ATOM   1751 C CD  . ARG A 1 230 ? 48.13600 54.71300 -12.65900 1.000 27.35000 ? 274 ARG A CD  1 
ATOM   1752 N NE  . ARG A 1 230 ? 48.29000 55.56300 -13.83500 1.000 29.47000 ? 274 ARG A NE  1 
ATOM   1753 C CZ  . ARG A 1 230 ? 49.15600 55.33800 -14.81400 1.000 27.44000 ? 274 ARG A CZ  1 
ATOM   1754 N NH1 . ARG A 1 230 ? 49.96300 54.29100 -14.79600 1.000 28.72000 ? 274 ARG A NH1 1 
ATOM   1755 N NH2 . ARG A 1 230 ? 49.21500 56.18800 -15.83500 1.000 30.62000 ? 274 ARG A NH2 1 
ATOM   1756 N N   . PHE A 1 231 ? 51.66000 52.32100 -10.97500 1.000 25.35000 ? 275 PHE A N   1 
ATOM   1757 C CA  . PHE A 1 231 ? 52.89600 52.29300 -11.74800 1.000 23.40000 ? 275 PHE A CA  1 
ATOM   1758 C C   . PHE A 1 231 ? 53.58600 50.93800 -11.79100 1.000 24.80000 ? 275 PHE A C   1 
ATOM   1759 O O   . PHE A 1 231 ? 54.28900 50.65600 -12.76400 1.000 25.11000 ? 275 PHE A O   1 
ATOM   1760 C CB  . PHE A 1 231 ? 53.87600 53.34600 -11.21300 1.000 21.16000 ? 275 PHE A CB  1 
ATOM   1761 C CG  . PHE A 1 231 ? 53.41600 54.75900 -11.43100 1.000 23.96000 ? 275 PHE A CG  1 
ATOM   1762 C CD1 . PHE A 1 231 ? 53.43200 55.31600 -12.69900 1.000 22.39000 ? 275 PHE A CD1 1 
ATOM   1763 C CD2 . PHE A 1 231 ? 52.96000 55.52700 -10.37300 1.000 21.34000 ? 275 PHE A CD2 1 
ATOM   1764 C CE1 . PHE A 1 231 ? 53.00700 56.61200 -12.90800 1.000 22.32000 ? 275 PHE A CE1 1 
ATOM   1765 C CE2 . PHE A 1 231 ? 52.53400 56.82500 -10.57600 1.000 20.94000 ? 275 PHE A CE2 1 
ATOM   1766 C CZ  . PHE A 1 231 ? 52.55800 57.36800 -11.84600 1.000 23.20000 ? 275 PHE A CZ  1 
ATOM   1767 N N   . VAL A 1 232 ? 53.41300 50.09200 -10.77800 1.000 24.31000 ? 276 VAL A N   1 
ATOM   1768 C CA  . VAL A 1 232 ? 53.95800 48.74100 -10.86100 1.000 25.77000 ? 276 VAL A CA  1 
ATOM   1769 C C   . VAL A 1 232 ? 53.00100 47.80100 -11.58900 1.000 26.47000 ? 276 VAL A C   1 
ATOM   1770 O O   . VAL A 1 232 ? 53.44500 46.90700 -12.31500 1.000 27.38000 ? 276 VAL A O   1 
ATOM   1771 C CB  . VAL A 1 232 ? 54.30600 48.20600 -9.46100  1.000 24.27000 ? 276 VAL A CB  1 
ATOM   1772 C CG1 . VAL A 1 232 ? 54.85200 46.79000 -9.53600  1.000 23.12000 ? 276 VAL A CG1 1 
ATOM   1773 C CG2 . VAL A 1 232 ? 55.30900 49.12000 -8.77800  1.000 23.44000 ? 276 VAL A CG2 1 
ATOM   1774 N N   . ASP A 1 233 ? 51.69400 47.99400 -11.42700 1.000 26.42000 ? 277 ASP A N   1 
ATOM   1775 C CA  . ASP A 1 233 ? 50.69100 47.15700 -12.07300 1.000 27.76000 ? 277 ASP A CA  1 
ATOM   1776 C C   . ASP A 1 233 ? 50.04100 47.82100 -13.27900 1.000 29.03000 ? 277 ASP A C   1 
ATOM   1777 O O   . ASP A 1 233 ? 49.19200 47.19600 -13.92100 1.000 32.00000 ? 277 ASP A O   1 
ATOM   1778 C CB  . ASP A 1 233 ? 49.60000 46.76200 -11.07100 1.000 28.05000 ? 277 ASP A CB  1 
ATOM   1779 C CG  . ASP A 1 233 ? 50.13500 45.95000 -9.90900  1.000 28.61000 ? 277 ASP A CG  1 
ATOM   1780 O OD1 . ASP A 1 233 ? 51.37100 45.81700 -9.79300  1.000 29.26000 ? 277 ASP A OD1 1 
ATOM   1781 O OD2 . ASP A 1 233 ? 49.31700 45.44200 -9.11400  1.000 27.91000 ? 277 ASP A OD2 1 
ATOM   1782 N N   . GLU A 1 234 ? 50.40600 49.06700 -13.59500 1.000 29.22000 ? 278 GLU A N   1 
ATOM   1783 C CA  . GLU A 1 234 ? 49.74600 49.83500 -14.65600 1.000 31.82000 ? 278 GLU A CA  1 
ATOM   1784 C C   . GLU A 1 234 ? 48.23800 49.89400 -14.42900 1.000 31.03000 ? 278 GLU A C   1 
ATOM   1785 O O   . GLU A 1 234 ? 47.45400 50.03200 -15.37000 1.000 29.93000 ? 278 GLU A O   1 
ATOM   1786 C CB  . GLU A 1 234 ? 50.06000 49.26400 -16.04200 1.000 33.85000 ? 278 GLU A CB  1 
ATOM   1787 C CG  . GLU A 1 234 ? 51.54300 49.18600 -16.37200 1.000 40.02000 ? 278 GLU A CG  1 
ATOM   1788 C CD  . GLU A 1 234 ? 51.80900 48.56000 -17.73200 1.000 44.84000 ? 278 GLU A CD  1 
ATOM   1789 O OE1 . GLU A 1 234 ? 50.84400 48.36300 -18.50200 1.000 42.85000 ? 278 GLU A OE1 1 
ATOM   1790 O OE2 . GLU A 1 234 ? 52.98500 48.26500 -18.03000 1.000 46.01000 ? 278 GLU A OE2 1 
ATOM   1791 N N   . ASP A 1 235 ? 47.83000 49.78400 -13.16700 1.000 29.09000 ? 279 ASP A N   1 
ATOM   1792 C CA  . ASP A 1 235 ? 46.42500 49.64000 -12.79600 1.000 27.15000 ? 279 ASP A CA  1 
ATOM   1793 C C   . ASP A 1 235 ? 45.80700 51.02900 -12.71700 1.000 28.50000 ? 279 ASP A C   1 
ATOM   1794 O O   . ASP A 1 235 ? 45.93900 51.72600 -11.70700 1.000 26.55000 ? 279 ASP A O   1 
ATOM   1795 C CB  . ASP A 1 235 ? 46.30300 48.88700 -11.47700 1.000 28.53000 ? 279 ASP A CB  1 
ATOM   1796 C CG  . ASP A 1 235 ? 44.90400 48.38100 -11.22100 1.000 28.30000 ? 279 ASP A CG  1 
ATOM   1797 O OD1 . ASP A 1 235 ? 43.97800 48.80200 -11.94300 1.000 31.40000 ? 279 ASP A OD1 1 
ATOM   1798 O OD2 . ASP A 1 235 ? 44.73000 47.55000 -10.30500 1.000 27.35000 ? 279 ASP A OD2 1 
ATOM   1799 N N   . THR A 1 236 ? 45.12700 51.43400 -13.78900 1.000 28.24000 ? 280 THR A N   1 
ATOM   1800 C CA  . THR A 1 236 ? 44.47800 52.73800 -13.82500 1.000 25.47000 ? 280 THR A CA  1 
ATOM   1801 C C   . THR A 1 236 ? 43.21400 52.79500 -12.98000 1.000 23.67000 ? 280 THR A C   1 
ATOM   1802 O O   . THR A 1 236 ? 42.62400 53.87400 -12.85500 1.000 24.81000 ? 280 THR A O   1 
ATOM   1803 C CB  . THR A 1 236 ? 44.15900 53.12200 -15.27000 1.000 25.21000 ? 280 THR A CB  1 
ATOM   1804 O OG1 . THR A 1 236 ? 43.46400 52.04400 -15.91000 1.000 25.62000 ? 280 THR A OG1 1 
ATOM   1805 C CG2 . THR A 1 236 ? 45.44200 53.41600 -16.03300 1.000 25.84000 ? 280 THR A CG2 1 
ATOM   1806 N N   . ARG A 1 237 ? 42.78300 51.67200 -12.39900 1.000 24.77000 ? 281 ARG A N   1 
ATOM   1807 C CA  . ARG A 1 237 ? 41.68300 51.70800 -11.44400 1.000 24.67000 ? 281 ARG A CA  1 
ATOM   1808 C C   . ARG A 1 237 ? 42.03100 52.51900 -10.20400 1.000 25.56000 ? 281 ARG A C   1 
ATOM   1809 O O   . ARG A 1 237 ? 41.12700 52.92500 -9.46700  1.000 28.81000 ? 281 ARG A O   1 
ATOM   1810 C CB  . ARG A 1 237 ? 41.28900 50.29000 -11.03300 1.000 24.75000 ? 281 ARG A CB  1 
ATOM   1811 C CG  . ARG A 1 237 ? 40.87400 49.39200 -12.18200 1.000 25.48000 ? 281 ARG A CG  1 
ATOM   1812 C CD  . ARG A 1 237 ? 40.64100 47.97500 -11.69200 1.000 26.62000 ? 281 ARG A CD  1 
ATOM   1813 N NE  . ARG A 1 237 ? 41.84500 47.39900 -11.10600 1.000 26.83000 ? 281 ARG A NE  1 
ATOM   1814 C CZ  . ARG A 1 237 ? 41.89200 46.22500 -10.49200 1.000 25.44000 ? 281 ARG A CZ  1 
ATOM   1815 N NH1 . ARG A 1 237 ? 40.81200 45.47400 -10.35400 1.000 26.66000 ? 281 ARG A NH1 1 
ATOM   1816 N NH2 . ARG A 1 237 ? 43.05100 45.79500 -10.00200 1.000 25.41000 ? 281 ARG A NH2 1 
ATOM   1817 N N   . TYR A 1 238 ? 43.31800 52.76000 -9.95600  1.000 26.09000 ? 282 TYR A N   1 
ATOM   1818 C CA  . TYR A 1 238 ? 43.77000 53.50900 -8.79300  1.000 24.70000 ? 282 TYR A CA  1 
ATOM   1819 C C   . TYR A 1 238 ? 44.12100 54.95400 -9.11600  1.000 24.49000 ? 282 TYR A C   1 
ATOM   1820 O O   . TYR A 1 238 ? 44.53800 55.69000 -8.21700  1.000 24.02000 ? 282 TYR A O   1 
ATOM   1821 C CB  . TYR A 1 238 ? 44.97500 52.81200 -8.15600  1.000 23.31000 ? 282 TYR A CB  1 
ATOM   1822 C CG  . TYR A 1 238 ? 44.62200 51.52200 -7.45500  1.000 25.69000 ? 282 TYR A CG  1 
ATOM   1823 C CD1 . TYR A 1 238 ? 44.40300 50.35400 -8.17500  1.000 24.75000 ? 282 TYR A CD1 1 
ATOM   1824 C CD2 . TYR A 1 238 ? 44.50400 51.47200 -6.07300  1.000 25.89000 ? 282 TYR A CD2 1 
ATOM   1825 C CE1 . TYR A 1 238 ? 44.07800 49.17400 -7.53800  1.000 26.99000 ? 282 TYR A CE1 1 
ATOM   1826 C CE2 . TYR A 1 238 ? 44.17900 50.29400 -5.42700  1.000 27.12000 ? 282 TYR A CE2 1 
ATOM   1827 C CZ  . TYR A 1 238 ? 43.96800 49.14800 -6.16400  1.000 26.24000 ? 282 TYR A CZ  1 
ATOM   1828 O OH  . TYR A 1 238 ? 43.64400 47.97400 -5.52700  1.000 27.75000 ? 282 TYR A OH  1 
ATOM   1829 N N   . SER A 1 239 ? 43.96500 55.37600 -10.37200 1.000 25.69000 ? 283 SER A N   1 
ATOM   1830 C CA  . SER A 1 239 ? 44.20200 56.76900 -10.72900 1.000 23.94000 ? 283 SER A CA  1 
ATOM   1831 C C   . SER A 1 239 ? 43.19600 57.70800 -10.07600 1.000 23.27000 ? 283 SER A C   1 
ATOM   1832 O O   . SER A 1 239 ? 43.48500 58.90000 -9.92700  1.000 24.77000 ? 283 SER A O   1 
ATOM   1833 C CB  . SER A 1 239 ? 44.16000 56.93300 -12.24900 1.000 26.46000 ? 283 SER A CB  1 
ATOM   1834 O OG  . SER A 1 239 ? 45.10700 56.08900 -12.88200 1.000 27.44000 ? 283 SER A OG  1 
ATOM   1835 N N   . GLN A 1 240 ? 42.02500 57.19700 -9.68600  1.000 23.90000 ? 284 GLN A N   1 
ATOM   1836 C CA  . GLN A 1 240 ? 41.02700 58.03100 -9.02600  1.000 23.69000 ? 284 GLN A CA  1 
ATOM   1837 C C   . GLN A 1 240 ? 41.51200 58.53000 -7.67100  1.000 25.30000 ? 284 GLN A C   1 
ATOM   1838 O O   . GLN A 1 240 ? 41.09100 59.60100 -7.21800  1.000 25.28000 ? 284 GLN A O   1 
ATOM   1839 C CB  . GLN A 1 240 ? 39.72300 57.25100 -8.86100  1.000 23.00000 ? 284 GLN A CB  1 
ATOM   1840 C CG  . GLN A 1 240 ? 39.92200 55.87100 -8.25700  1.000 23.03000 ? 284 GLN A CG  1 
ATOM   1841 C CD  . GLN A 1 240 ? 38.61700 55.17300 -7.93900  1.000 25.66000 ? 284 GLN A CD  1 
ATOM   1842 O OE1 . GLN A 1 240 ? 38.45900 53.98000 -8.20100  1.000 30.05000 ? 284 GLN A OE1 1 
ATOM   1843 N NE2 . GLN A 1 240 ? 37.67700 55.91000 -7.35900  1.000 25.44000 ? 284 GLN A NE2 1 
ATOM   1844 N N   . PHE A 1 241 ? 42.38900 57.77600 -7.01000  1.000 23.81000 ? 285 PHE A N   1 
ATOM   1845 C CA  . PHE A 1 241 ? 42.89700 58.15900 -5.70100  1.000 22.32000 ? 285 PHE A CA  1 
ATOM   1846 C C   . PHE A 1 241 ? 44.10900 59.07800 -5.77600  1.000 22.32000 ? 285 PHE A C   1 
ATOM   1847 O O   . PHE A 1 241 ? 44.45700 59.70000 -4.76700  1.000 25.39000 ? 285 PHE A O   1 
ATOM   1848 C CB  . PHE A 1 241 ? 43.26000 56.91200 -4.88800  1.000 21.74000 ? 285 PHE A CB  1 
ATOM   1849 C CG  . PHE A 1 241 ? 42.19600 55.85400 -4.89100  1.000 20.38000 ? 285 PHE A CG  1 
ATOM   1850 C CD1 . PHE A 1 241 ? 40.97900 56.07200 -4.26600  1.000 21.87000 ? 285 PHE A CD1 1 
ATOM   1851 C CD2 . PHE A 1 241 ? 42.41700 54.63800 -5.51200  1.000 20.69000 ? 285 PHE A CD2 1 
ATOM   1852 C CE1 . PHE A 1 241 ? 40.00100 55.09800 -4.26800  1.000 21.81000 ? 285 PHE A CE1 1 
ATOM   1853 C CE2 . PHE A 1 241 ? 41.44300 53.65900 -5.51600  1.000 22.06000 ? 285 PHE A CE2 1 
ATOM   1854 C CZ  . PHE A 1 241 ? 40.23400 53.88900 -4.89300  1.000 22.67000 ? 285 PHE A CZ  1 
ATOM   1855 N N   . LEU A 1 242 ? 44.75500 59.18200 -6.94000  1.000 24.18000 ? 286 LEU A N   1 
ATOM   1856 C CA  . LEU A 1 242 ? 45.95300 59.99300 -7.09100  1.000 21.68000 ? 286 LEU A CA  1 
ATOM   1857 C C   . LEU A 1 242 ? 45.74100 61.26700 -7.89500  1.000 22.68000 ? 286 LEU A C   1 
ATOM   1858 O O   . LEU A 1 242 ? 46.50000 62.22300 -7.70900  1.000 23.78000 ? 286 LEU A O   1 
ATOM   1859 C CB  . LEU A 1 242 ? 47.06800 59.17400 -7.75600  1.000 23.80000 ? 286 LEU A CB  1 
ATOM   1860 C CG  . LEU A 1 242 ? 47.54600 57.93900 -6.99500  1.000 23.84000 ? 286 LEU A CG  1 
ATOM   1861 C CD1 . LEU A 1 242 ? 48.49000 57.12400 -7.85900  1.000 23.69000 ? 286 LEU A CD1 1 
ATOM   1862 C CD2 . LEU A 1 242 ? 48.22300 58.34700 -5.69700  1.000 22.24000 ? 286 LEU A CD2 1 
ATOM   1863 N N   . CYS A 1 243 ? 44.74300 61.30300 -8.78300  1.000 24.18000 ? 287 CYS A N   1 
ATOM   1864 C CA  . CYS A 1 243 ? 44.46500 62.47500 -9.60400  1.000 23.53000 ? 287 CYS A CA  1 
ATOM   1865 C C   . CYS A 1 243 ? 42.95500 62.69000 -9.64000  1.000 20.85000 ? 287 CYS A C   1 
ATOM   1866 O O   . CYS A 1 243 ? 42.20800 61.75300 -9.97500  1.000 24.31000 ? 287 CYS A O   1 
ATOM   1867 C CB  . CYS A 1 243 ? 45.01700 62.31800 -11.02200 1.000 23.74000 ? 287 CYS A CB  1 
ATOM   1868 S SG  . CYS A 1 243 ? 46.80000 62.04900 -11.10500 1.000 26.79000 ? 287 CYS A SG  1 
ATOM   1869 N N   . PRO A 1 244 ? 42.46500 63.89300 -9.29500  1.000 19.28000 ? 288 PRO A N   1 
ATOM   1870 C CA  . PRO A 1 244 ? 43.24200 65.05200 -8.83600  1.000 20.90000 ? 288 PRO A CA  1 
ATOM   1871 C C   . PRO A 1 244 ? 43.85600 64.85400 -7.44900  1.000 22.74000 ? 288 PRO A C   1 
ATOM   1872 O O   . PRO A 1 244 ? 43.62300 63.81800 -6.82300  1.000 23.48000 ? 288 PRO A O   1 
ATOM   1873 C CB  . PRO A 1 244 ? 42.20800 66.18000 -8.81600  1.000 21.09000 ? 288 PRO A CB  1 
ATOM   1874 C CG  . PRO A 1 244 ? 40.90400 65.48900 -8.64100  1.000 21.00000 ? 288 PRO A CG  1 
ATOM   1875 C CD  . PRO A 1 244 ? 41.02800 64.19700 -9.38700  1.000 19.64000 ? 288 PRO A CD  1 
ATOM   1876 N N   . ASN A 1 245 ? 44.62700 65.83800 -6.99400  1.000 22.21000 ? 289 ASN A N   1 
ATOM   1877 C CA  . ASN A 1 245 ? 45.39900 65.68600 -5.77000  1.000 23.52000 ? 289 ASN A CA  1 
ATOM   1878 C C   . ASN A 1 245 ? 44.48600 65.32400 -4.60100  1.000 21.90000 ? 289 ASN A C   1 
ATOM   1879 O O   . ASN A 1 245 ? 43.38400 65.87100 -4.48100  1.000 23.17000 ? 289 ASN A O   1 
ATOM   1880 C CB  . ASN A 1 245 ? 46.16200 66.97300 -5.45100  1.000 22.55000 ? 289 ASN A CB  1 
ATOM   1881 C CG  . ASN A 1 245 ? 47.16300 67.33600 -6.52400  1.000 22.53000 ? 289 ASN A CG  1 
ATOM   1882 O OD1 . ASN A 1 245 ? 47.47900 66.52600 -7.39400  1.000 23.80000 ? 289 ASN A OD1 1 
ATOM   1883 N ND2 . ASN A 1 245 ? 47.67700 68.55800 -6.46200  1.000 21.86000 ? 289 ASN A ND2 1 
ATOM   1884 N N   . PRO A 1 246 ? 44.90200 64.39800 -3.73800  1.000 23.38000 ? 290 PRO A N   1 
ATOM   1885 C CA  . PRO A 1 246 ? 44.07900 64.05000 -2.57400  1.000 22.54000 ? 290 PRO A CA  1 
ATOM   1886 C C   . PRO A 1 246 ? 43.82300 65.25900 -1.68700  1.000 20.77000 ? 290 PRO A C   1 
ATOM   1887 O O   . PRO A 1 246 ? 44.59700 66.21900 -1.66100  1.000 21.61000 ? 290 PRO A O   1 
ATOM   1888 C CB  . PRO A 1 246 ? 44.91800 62.99000 -1.85100  1.000 23.71000 ? 290 PRO A CB  1 
ATOM   1889 C CG  . PRO A 1 246 ? 45.78000 62.40100 -2.91900  1.000 22.27000 ? 290 PRO A CG  1 
ATOM   1890 C CD  . PRO A 1 246 ? 46.07900 63.52200 -3.87100  1.000 21.70000 ? 290 PRO A CD  1 
ATOM   1891 N N   . THR A 1 247 ? 42.70500 65.20100 -0.96300  1.000 24.17000 ? 291 THR A N   1 
ATOM   1892 C CA  . THR A 1 247 ? 42.24600 66.29400 -0.11600  1.000 25.49000 ? 291 THR A CA  1 
ATOM   1893 C C   . THR A 1 247 ? 42.12400 65.86200 1.34300   1.000 24.03000 ? 291 THR A C   1 
ATOM   1894 O O   . THR A 1 247 ? 41.33900 66.44100 2.09800   1.000 27.56000 ? 291 THR A O   1 
ATOM   1895 C CB  . THR A 1 247 ? 40.90200 66.83100 -0.61400  1.000 23.32000 ? 291 THR A CB  1 
ATOM   1896 O OG1 . THR A 1 247 ? 39.90200 65.81500 -0.47700  1.000 25.30000 ? 291 THR A OG1 1 
ATOM   1897 C CG2 . THR A 1 247 ? 40.99900 67.25100 -2.07200  1.000 23.64000 ? 291 THR A CG2 1 
ATOM   1898 N N   . ASP A 1 248 ? 42.88500 64.84600 1.74700   1.000 24.63000 ? 292 ASP A N   1 
ATOM   1899 C CA  . ASP A 1 248 ? 42.78200 64.31900 3.10100   1.000 24.58000 ? 292 ASP A CA  1 
ATOM   1900 C C   . ASP A 1 248 ? 43.11700 65.39200 4.12800   1.000 23.22000 ? 292 ASP A C   1 
ATOM   1901 O O   . ASP A 1 248 ? 44.00000 66.22900 3.91600   1.000 20.77000 ? 292 ASP A O   1 
ATOM   1902 C CB  . ASP A 1 248 ? 43.71500 63.12600 3.27700   1.000 22.95000 ? 292 ASP A CB  1 
ATOM   1903 C CG  . ASP A 1 248 ? 43.34700 61.97000 2.38100   1.000 24.09000 ? 292 ASP A CG  1 
ATOM   1904 O OD1 . ASP A 1 248 ? 43.23100 62.18000 1.15700   1.000 24.41000 ? 292 ASP A OD1 1 
ATOM   1905 O OD2 . ASP A 1 248 ? 43.17000 60.85100 2.90400   1.000 25.38000 ? 292 ASP A OD2 1 
ATOM   1906 N N   . ARG A 1 249 ? 42.39300 65.36400 5.25000   1.000 25.96000 ? 293 ARG A N   1 
ATOM   1907 C CA  . ARG A 1 249 ? 42.65600 66.30900 6.32900   1.000 24.56000 ? 293 ARG A CA  1 
ATOM   1908 C C   . ARG A 1 249 ? 44.05800 66.13000 6.89700   1.000 21.41000 ? 293 ARG A C   1 
ATOM   1909 O O   . ARG A 1 249 ? 44.68000 67.10500 7.33200   1.000 22.94000 ? 293 ARG A O   1 
ATOM   1910 C CB  . ARG A 1 249 ? 41.60800 66.14900 7.43200   1.000 29.54000 ? 293 ARG A CB  1 
ATOM   1911 C CG  . ARG A 1 249 ? 41.63300 67.26100 8.47000   1.000 31.39000 ? 293 ARG A CG  1 
ATOM   1912 C CD  . ARG A 1 249 ? 41.06300 66.81400 9.81300   1.000 35.74000 ? 293 ARG A CD  1 
ATOM   1913 N NE  . ARG A 1 249 ? 39.61000 66.68500 9.81500   1.000 33.96000 ? 293 ARG A NE  1 
ATOM   1914 C CZ  . ARG A 1 249 ? 38.95700 65.54200 9.65300   1.000 30.54000 ? 293 ARG A CZ  1 
ATOM   1915 N NH1 . ARG A 1 249 ? 39.59600 64.40500 9.43200   1.000 33.19000 ? 293 ARG A NH1 1 
ATOM   1916 N NH2 . ARG A 1 249 ? 37.62900 65.54000 9.71800   1.000 31.67000 ? 293 ARG A NH2 1 
ATOM   1917 N N   . ALA A 1 250 ? 44.57500 64.89800 6.89500   1.000 20.79000 ? 294 ALA A N   1 
ATOM   1918 C CA  . ALA A 1 250 ? 45.92800 64.63300 7.36900   1.000 20.56000 ? 294 ALA A CA  1 
ATOM   1919 C C   . ALA A 1 250 ? 46.99800 65.19200 6.44300   1.000 22.67000 ? 294 ALA A C   1 
ATOM   1920 O O   . ALA A 1 250 ? 48.16400 65.26400 6.84500   1.000 21.64000 ? 294 ALA A O   1 
ATOM   1921 C CB  . ALA A 1 250 ? 46.14100 63.12900 7.54400   1.000 19.78000 ? 294 ALA A CB  1 
ATOM   1922 N N   . ILE A 1 251 ? 46.63800 65.57800 5.22300   1.000 22.68000 ? 295 ILE A N   1 
ATOM   1923 C CA  . ILE A 1 251 ? 47.59100 66.11900 4.26100   1.000 21.34000 ? 295 ILE A CA  1 
ATOM   1924 C C   . ILE A 1 251 ? 47.61100 67.63300 4.40000   1.000 18.81000 ? 295 ILE A C   1 
ATOM   1925 O O   . ILE A 1 251 ? 46.57400 68.29200 4.26400   1.000 24.37000 ? 295 ILE A O   1 
ATOM   1926 C CB  . ILE A 1 251 ? 47.23200 65.70900 2.82500   1.000 21.64000 ? 295 ILE A CB  1 
ATOM   1927 C CG1 . ILE A 1 251 ? 47.20100 64.18800 2.68900   1.000 23.15000 ? 295 ILE A CG1 1 
ATOM   1928 C CG2 . ILE A 1 251 ? 48.22600 66.31200 1.84000   1.000 22.09000 ? 295 ILE A CG2 1 
ATOM   1929 C CD1 . ILE A 1 251 ? 46.79500 63.72300 1.31300   1.000 21.80000 ? 295 ILE A CD1 1 
ATOM   1930 N N   . CYS A 1 252 ? 48.79000 68.18700 4.66400   1.000 21.18000 ? 296 CYS A N   1 
ATOM   1931 C CA  . CYS A 1 252 ? 48.94400 69.63000 4.77000   1.000 21.28000 ? 296 CYS A CA  1 
ATOM   1932 C C   . CYS A 1 252 ? 49.35800 70.27800 3.46000   1.000 24.12000 ? 296 CYS A C   1 
ATOM   1933 O O   . CYS A 1 252 ? 49.20500 71.49600 3.31100   1.000 26.48000 ? 296 CYS A O   1 
ATOM   1934 C CB  . CYS A 1 252 ? 49.96400 69.97100 5.85900   1.000 24.42000 ? 296 CYS A CB  1 
ATOM   1935 S SG  . CYS A 1 252 ? 49.20200 70.38900 7.44300   1.000 31.62000 ? 296 CYS A SG  1 
ATOM   1936 N N   . GLU A 1 253 ? 49.86700 69.49600 2.51200   1.000 22.32000 ? 297 GLU A N   1 
ATOM   1937 C CA  . GLU A 1 253 ? 50.23700 70.01400 1.20500   1.000 23.33000 ? 297 GLU A CA  1 
ATOM   1938 C C   . GLU A 1 253 ? 50.41600 68.84400 0.25300   1.000 22.17000 ? 297 GLU A C   1 
ATOM   1939 O O   . GLU A 1 253 ? 50.95200 67.80400 0.64100   1.000 20.60000 ? 297 GLU A O   1 
ATOM   1940 C CB  . GLU A 1 253 ? 51.52600 70.84000 1.28100   1.000 23.26000 ? 297 GLU A CB  1 
ATOM   1941 C CG  . GLU A 1 253 ? 51.80300 71.64700 0.03900   1.000 25.98000 ? 297 GLU A CG  1 
ATOM   1942 C CD  . GLU A 1 253 ? 52.96600 72.58300 0.22400   1.000 26.35000 ? 297 GLU A CD  1 
ATOM   1943 O OE1 . GLU A 1 253 ? 54.05400 72.10500 0.60100   1.000 27.83000 ? 297 GLU A OE1 1 
ATOM   1944 O OE2 . GLU A 1 253 ? 52.78500 73.79900 0.01300   1.000 33.66000 ? 297 GLU A OE2 1 
ATOM   1945 N N   . TYR A 1 254 ? 49.95400 69.01500 -0.98300  1.000 23.30000 ? 298 TYR A N   1 
ATOM   1946 C CA  . TYR A 1 254 ? 50.09400 67.98000 -1.99700  1.000 21.06000 ? 298 TYR A CA  1 
ATOM   1947 C C   . TYR A 1 254 ? 50.38800 68.62400 -3.34200  1.000 21.76000 ? 298 TYR A C   1 
ATOM   1948 O O   . TYR A 1 254 ? 49.64700 69.50500 -3.78700  1.000 23.97000 ? 298 TYR A O   1 
ATOM   1949 C CB  . TYR A 1 254 ? 48.83200 67.11200 -2.09200  1.000 19.23000 ? 298 TYR A CB  1 
ATOM   1950 C CG  . TYR A 1 254 ? 49.07100 65.76000 -2.73100  1.000 21.79000 ? 298 TYR A CG  1 
ATOM   1951 C CD1 . TYR A 1 254 ? 49.19100 65.63200 -4.10900  1.000 20.53000 ? 298 TYR A CD1 1 
ATOM   1952 C CD2 . TYR A 1 254 ? 49.17500 64.61100 -1.95600  1.000 17.92000 ? 298 TYR A CD2 1 
ATOM   1953 C CE1 . TYR A 1 254 ? 49.41200 64.40000 -4.69600  1.000 20.82000 ? 298 TYR A CE1 1 
ATOM   1954 C CE2 . TYR A 1 254 ? 49.39400 63.37600 -2.53500  1.000 19.59000 ? 298 TYR A CE2 1 
ATOM   1955 C CZ  . TYR A 1 254 ? 49.51100 63.27600 -3.90600  1.000 22.70000 ? 298 TYR A CZ  1 
ATOM   1956 O OH  . TYR A 1 254 ? 49.72800 62.04800 -4.49000  1.000 20.66000 ? 298 TYR A OH  1 
ATOM   1957 N N   . ARG A 1 255 ? 51.46700 68.18200 -3.98200  1.000 20.88000 ? 299 ARG A N   1 
ATOM   1958 C CA  . ARG A 1 255 ? 51.83300 68.61400 -5.32200  1.000 22.06000 ? 299 ARG A CA  1 
ATOM   1959 C C   . ARG A 1 255 ? 51.96600 67.38800 -6.21600  1.000 21.43000 ? 299 ARG A C   1 
ATOM   1960 O O   . ARG A 1 255 ? 52.34700 66.30900 -5.75500  1.000 21.12000 ? 299 ARG A O   1 
ATOM   1961 C CB  . ARG A 1 255 ? 53.14800 69.40400 -5.31700  1.000 21.02000 ? 299 ARG A CB  1 
ATOM   1962 C CG  . ARG A 1 255 ? 53.17100 70.59100 -4.36600  1.000 22.40000 ? 299 ARG A CG  1 
ATOM   1963 C CD  . ARG A 1 255 ? 54.59300 71.09100 -4.14900  1.000 25.18000 ? 299 ARG A CD  1 
ATOM   1964 N NE  . ARG A 1 255 ? 54.63500 72.28800 -3.31700  1.000 29.41000 ? 299 ARG A NE  1 
ATOM   1965 C CZ  . ARG A 1 255 ? 55.74800 72.88800 -2.91700  1.000 24.50000 ? 299 ARG A CZ  1 
ATOM   1966 N NH1 . ARG A 1 255 ? 56.94200 72.41600 -3.23600  1.000 22.75000 ? 299 ARG A NH1 1 
ATOM   1967 N NH2 . ARG A 1 255 ? 55.66100 73.99200 -2.17900  1.000 26.54000 ? 299 ARG A NH2 1 
ATOM   1968 N N   . SER A 1 256 ? 51.64800 67.55400 -7.49800  1.000 23.47000 ? 300 SER A N   1 
ATOM   1969 C CA  . SER A 1 256 ? 51.70600 66.43400 -8.42800  1.000 20.78000 ? 300 SER A CA  1 
ATOM   1970 C C   . SER A 1 256 ? 51.79700 66.96100 -9.85400  1.000 23.64000 ? 300 SER A C   1 
ATOM   1971 O O   . SER A 1 256 ? 51.61000 68.15100 -10.11600 1.000 20.25000 ? 300 SER A O   1 
ATOM   1972 C CB  . SER A 1 256 ? 50.49000 65.51800 -8.27800  1.000 21.40000 ? 300 SER A CB  1 
ATOM   1973 O OG  . SER A 1 256 ? 49.32200 66.15600 -8.76200  1.000 22.72000 ? 300 SER A OG  1 
ATOM   1974 N N   . THR A 1 257 ? 52.08800 66.04300 -10.77400 1.000 25.47000 ? 301 THR A N   1 
ATOM   1975 C CA  . THR A 1 257 ? 52.09000 66.31200 -12.20700 1.000 23.09000 ? 301 THR A CA  1 
ATOM   1976 C C   . THR A 1 257 ? 50.93500 65.59100 -12.89800 1.000 26.27000 ? 301 THR A C   1 
ATOM   1977 O O   . THR A 1 257 ? 51.07200 65.09100 -14.01600 1.000 30.80000 ? 301 THR A O   1 
ATOM   1978 C CB  . THR A 1 257 ? 53.42500 65.91600 -12.83400 1.000 19.49000 ? 301 THR A CB  1 
ATOM   1979 O OG1 . THR A 1 257 ? 53.73700 64.56000 -12.49200 1.000 21.70000 ? 301 THR A OG1 1 
ATOM   1980 C CG2 . THR A 1 257 ? 54.53600 66.82700 -12.34200 1.000 18.25000 ? 301 THR A CG2 1 
ATOM   1981 N N   . CYS A 1 258 ? 49.78800 65.52400 -12.22400 1.000 25.88000 ? 302 CYS A N   1 
ATOM   1982 C CA  . CYS A 1 258 ? 48.60400 64.91200 -12.80600 1.000 26.42000 ? 302 CYS A CA  1 
ATOM   1983 C C   . CYS A 1 258 ? 48.19700 65.66100 -14.07400 1.000 26.94000 ? 302 CYS A C   1 
ATOM   1984 O O   . CYS A 1 258 ? 48.37700 66.87800 -14.17000 1.000 25.63000 ? 302 CYS A O   1 
ATOM   1985 C CB  . CYS A 1 258 ? 47.44800 64.92500 -11.80700 1.000 28.55000 ? 302 CYS A CB  1 
ATOM   1986 S SG  . CYS A 1 258 ? 47.60300 63.78200 -10.41800 1.000 29.29000 ? 302 CYS A SG  1 
ATOM   1987 N N   . PRO A 1 259 ? 47.63600 64.95700 -15.07000 1.000 29.44000 ? 303 PRO A N   1 
ATOM   1988 C CA  . PRO A 1 259 ? 47.37000 63.51400 -15.06900 1.000 27.76000 ? 303 PRO A CA  1 
ATOM   1989 C C   . PRO A 1 259 ? 48.59200 62.67500 -15.44200 1.000 27.04000 ? 303 PRO A C   1 
ATOM   1990 O O   . PRO A 1 259 ? 49.52500 63.18200 -16.06600 1.000 28.83000 ? 303 PRO A O   1 
ATOM   1991 C CB  . PRO A 1 259 ? 46.27600 63.37100 -16.12400 1.000 27.52000 ? 303 PRO A CB  1 
ATOM   1992 C CG  . PRO A 1 259 ? 46.58700 64.45000 -17.09900 1.000 29.10000 ? 303 PRO A CG  1 
ATOM   1993 C CD  . PRO A 1 259 ? 47.11500 65.60500 -16.28800 1.000 30.19000 ? 303 PRO A CD  1 
ATOM   1994 N N   . TYR A 1 260 ? 48.57500 61.40200 -15.06000 1.000 27.52000 ? 304 TYR A N   1 
ATOM   1995 C CA  . TYR A 1 260 ? 49.68300 60.49700 -15.34300 1.000 29.97000 ? 304 TYR A CA  1 
ATOM   1996 C C   . TYR A 1 260 ? 49.43600 59.72100 -16.63300 1.000 30.51000 ? 304 TYR A C   1 
ATOM   1997 O O   . TYR A 1 260 ? 48.52100 58.90000 -16.70900 1.000 32.88000 ? 304 TYR A O   1 
ATOM   1998 C CB  . TYR A 1 260 ? 49.89500 59.53000 -14.17400 1.000 29.56000 ? 304 TYR A CB  1 
ATOM   1999 C CG  . TYR A 1 260 ? 50.23100 60.21300 -12.86500 1.000 25.75000 ? 304 TYR A CG  1 
ATOM   2000 C CD1 . TYR A 1 260 ? 51.05000 61.33300 -12.83600 1.000 24.64000 ? 304 TYR A CD1 1 
ATOM   2001 C CD2 . TYR A 1 260 ? 49.72100 59.74300 -11.66000 1.000 26.61000 ? 304 TYR A CD2 1 
ATOM   2002 C CE1 . TYR A 1 260 ? 51.36000 61.96300 -11.64800 1.000 23.92000 ? 304 TYR A CE1 1 
ATOM   2003 C CE2 . TYR A 1 260 ? 50.02500 60.37100 -10.46200 1.000 23.26000 ? 304 TYR A CE2 1 
ATOM   2004 C CZ  . TYR A 1 260 ? 50.84600 61.48100 -10.46400 1.000 23.52000 ? 304 TYR A CZ  1 
ATOM   2005 O OH  . TYR A 1 260 ? 51.15900 62.11800 -9.28600  1.000 22.81000 ? 304 TYR A OH  1 
ATOM   2006 N N   . PRO B 1 2   ? 80.22000 80.61600 -54.89000 1.000 41.45000 ? 46  PRO B N   1 
ATOM   2007 C CA  . PRO B 1 2   ? 80.49700 80.72700 -53.45500 1.000 43.90000 ? 46  PRO B CA  1 
ATOM   2008 C C   . PRO B 1 2   ? 79.21400 80.71400 -52.64100 1.000 45.64000 ? 46  PRO B C   1 
ATOM   2009 O O   . PRO B 1 2   ? 78.22500 81.31100 -53.06300 1.000 46.71000 ? 46  PRO B O   1 
ATOM   2010 C CB  . PRO B 1 2   ? 81.20400 82.08500 -53.32800 1.000 45.22000 ? 46  PRO B CB  1 
ATOM   2011 C CG  . PRO B 1 2   ? 81.39500 82.58900 -54.74500 1.000 39.73000 ? 46  PRO B CG  1 
ATOM   2012 C CD  . PRO B 1 2   ? 80.34600 81.91700 -55.56000 1.000 41.24000 ? 46  PRO B CD  1 
ATOM   2013 N N   . ASN B 1 3   ? 79.23600 80.05900 -51.49100 1.000 44.28000 ? 47  ASN B N   1 
ATOM   2014 C CA  . ASN B 1 3   ? 78.04700 79.94400 -50.65400 1.000 41.02000 ? 47  ASN B CA  1 
ATOM   2015 C C   . ASN B 1 3   ? 77.69600 81.28400 -50.01400 1.000 41.16000 ? 47  ASN B C   1 
ATOM   2016 O O   . ASN B 1 3   ? 78.51000 81.83300 -49.26000 1.000 42.35000 ? 47  ASN B O   1 
ATOM   2017 C CB  . ASN B 1 3   ? 78.28000 78.88600 -49.58100 1.000 39.77000 ? 47  ASN B CB  1 
ATOM   2018 C CG  . ASN B 1 3   ? 77.00100 78.46500 -48.88600 1.000 39.27000 ? 47  ASN B CG  1 
ATOM   2019 O OD1 . ASN B 1 3   ? 75.90300 78.65200 -49.41100 1.000 40.51000 ? 47  ASN B OD1 1 
ATOM   2020 N ND2 . ASN B 1 3   ? 77.13700 77.88400 -47.70100 1.000 39.95000 ? 47  ASN B ND2 1 
ATOM   2021 N N   . PRO B 1 4   ? 76.51300 81.83900 -50.27400 1.000 40.53000 ? 48  PRO B N   1 
ATOM   2022 C CA  . PRO B 1 4   ? 76.09900 83.08800 -49.62200 1.000 40.48000 ? 48  PRO B CA  1 
ATOM   2023 C C   . PRO B 1 4   ? 75.45500 82.90400 -48.25700 1.000 43.34000 ? 48  PRO B C   1 
ATOM   2024 O O   . PRO B 1 4   ? 75.08300 83.90300 -47.63000 1.000 43.78000 ? 48  PRO B O   1 
ATOM   2025 C CB  . PRO B 1 4   ? 75.08200 83.66400 -50.62300 1.000 40.85000 ? 48  PRO B CB  1 
ATOM   2026 C CG  . PRO B 1 4   ? 74.56300 82.47200 -51.40500 1.000 40.14000 ? 48  PRO B CG  1 
ATOM   2027 C CD  . PRO B 1 4   ? 75.44700 81.28200 -51.12600 1.000 40.46000 ? 48  PRO B CD  1 
ATOM   2028 N N   . TYR B 1 5   ? 75.31500 81.66500 -47.78900 1.000 43.71000 ? 49  TYR B N   1 
ATOM   2029 C CA  . TYR B 1 5   ? 74.71100 81.37000 -46.49800 1.000 42.36000 ? 49  TYR B CA  1 
ATOM   2030 C C   . TYR B 1 5   ? 75.74300 81.14500 -45.40100 1.000 41.44000 ? 49  TYR B C   1 
ATOM   2031 O O   . TYR B 1 5   ? 75.36200 80.88900 -44.25500 1.000 43.55000 ? 49  TYR B O   1 
ATOM   2032 C CB  . TYR B 1 5   ? 73.80400 80.13900 -46.60700 1.000 40.03000 ? 49  TYR B CB  1 
ATOM   2033 C CG  . TYR B 1 5   ? 72.75400 80.22500 -47.69400 1.000 37.92000 ? 49  TYR B CG  1 
ATOM   2034 C CD1 . TYR B 1 5   ? 72.10000 81.42000 -47.96300 1.000 39.59000 ? 49  TYR B CD1 1 
ATOM   2035 C CD2 . TYR B 1 5   ? 72.41900 79.11000 -48.45300 1.000 37.47000 ? 49  TYR B CD2 1 
ATOM   2036 C CE1 . TYR B 1 5   ? 71.14000 81.50200 -48.95500 1.000 38.78000 ? 49  TYR B CE1 1 
ATOM   2037 C CE2 . TYR B 1 5   ? 71.46000 79.18300 -49.44700 1.000 38.86000 ? 49  TYR B CE2 1 
ATOM   2038 C CZ  . TYR B 1 5   ? 70.82500 80.38100 -49.69400 1.000 36.87000 ? 49  TYR B CZ  1 
ATOM   2039 O OH  . TYR B 1 5   ? 69.87000 80.45800 -50.68200 1.000 35.93000 ? 49  TYR B OH  1 
ATOM   2040 N N   . GLU B 1 6   ? 77.03300 81.22800 -45.72000 1.000 38.91000 ? 50  GLU B N   1 
ATOM   2041 C CA  . GLU B 1 6   ? 78.06800 81.00700 -44.72000 1.000 41.67000 ? 50  GLU B CA  1 
ATOM   2042 C C   . GLU B 1 6   ? 78.12400 82.17700 -43.74700 1.000 44.94000 ? 50  GLU B C   1 
ATOM   2043 O O   . GLU B 1 6   ? 78.15100 83.34200 -44.15700 1.000 44.19000 ? 50  GLU B O   1 
ATOM   2044 C CB  . GLU B 1 6   ? 79.42500 80.81300 -45.39100 1.000 42.43000 ? 50  GLU B CB  1 
ATOM   2045 C CG  . GLU B 1 6   ? 79.54500 79.52900 -46.19000 1.000 41.75000 ? 50  GLU B CG  1 
ATOM   2046 C CD  . GLU B 1 6   ? 80.93100 79.33300 -46.77000 1.000 41.50000 ? 50  GLU B CD  1 
ATOM   2047 O OE1 . GLU B 1 6   ? 81.80700 80.18700 -46.52000 1.000 42.08000 ? 50  GLU B OE1 1 
ATOM   2048 O OE2 . GLU B 1 6   ? 81.14400 78.32500 -47.47500 1.000 41.15000 ? 50  GLU B OE2 1 
ATOM   2049 N N   . ARG B 1 7   ? 78.14300 81.86300 -42.45400 1.000 46.29000 ? 51  ARG B N   1 
ATOM   2050 C CA  . ARG B 1 7   ? 78.21100 82.86300 -41.40100 1.000 42.17000 ? 51  ARG B CA  1 
ATOM   2051 C C   . ARG B 1 7   ? 79.29100 82.47300 -40.40200 1.000 40.71000 ? 51  ARG B C   1 
ATOM   2052 O O   . ARG B 1 7   ? 79.55200 81.28900 -40.17500 1.000 41.76000 ? 51  ARG B O   1 
ATOM   2053 C CB  . ARG B 1 7   ? 76.86500 83.01500 -40.67700 1.000 40.45000 ? 51  ARG B CB  1 
ATOM   2054 C CG  . ARG B 1 7   ? 75.68700 83.32800 -41.58700 1.000 40.59000 ? 51  ARG B CG  1 
ATOM   2055 C CD  . ARG B 1 7   ? 75.82600 84.69200 -42.24400 1.000 41.35000 ? 51  ARG B CD  1 
ATOM   2056 N NE  . ARG B 1 7   ? 74.66400 85.02100 -43.06200 1.000 42.58000 ? 51  ARG B NE  1 
ATOM   2057 C CZ  . ARG B 1 7   ? 74.58100 84.80900 -44.36800 1.000 40.87000 ? 51  ARG B CZ  1 
ATOM   2058 N NH1 . ARG B 1 7   ? 75.58800 84.28900 -45.05000 1.000 40.72000 ? 51  ARG B NH1 1 
ATOM   2059 N NH2 . ARG B 1 7   ? 73.46100 85.13400 -45.00800 1.000 40.15000 ? 51  ARG B NH2 1 
ATOM   2060 N N   . GLY B 1 8   ? 79.91600 83.48400 -39.80500 1.000 43.08000 ? 52  GLY B N   1 
ATOM   2061 C CA  . GLY B 1 8   ? 80.93700 83.26400 -38.81000 1.000 43.80000 ? 52  GLY B CA  1 
ATOM   2062 C C   . GLY B 1 8   ? 82.25400 82.83700 -39.42100 1.000 43.13000 ? 52  GLY B C   1 
ATOM   2063 O O   . GLY B 1 8   ? 82.36300 82.61600 -40.63100 1.000 45.15000 ? 52  GLY B O   1 
ATOM   2064 N N   . PRO B 1 9   ? 83.28700 82.71500 -38.59100 1.000 44.77000 ? 53  PRO B N   1 
ATOM   2065 C CA  . PRO B 1 9   ? 84.60200 82.31500 -39.10100 1.000 45.54000 ? 53  PRO B CA  1 
ATOM   2066 C C   . PRO B 1 9   ? 84.62900 80.83500 -39.45400 1.000 46.11000 ? 53  PRO B C   1 
ATOM   2067 O O   . PRO B 1 9   ? 83.68500 80.08300 -39.20300 1.000 45.97000 ? 53  PRO B O   1 
ATOM   2068 C CB  . PRO B 1 9   ? 85.54300 82.63400 -37.93700 1.000 44.69000 ? 53  PRO B CB  1 
ATOM   2069 C CG  . PRO B 1 9   ? 84.68200 82.49100 -36.72800 1.000 45.87000 ? 53  PRO B CG  1 
ATOM   2070 C CD  . PRO B 1 9   ? 83.30600 82.95500 -37.13800 1.000 47.31000 ? 53  PRO B CD  1 
ATOM   2071 N N   . ASP B 1 10  ? 85.74100 80.42500 -40.05500 1.000 46.58000 ? 54  ASP B N   1 
ATOM   2072 C CA  . ASP B 1 10  ? 85.92700 79.02200 -40.39300 1.000 46.22000 ? 54  ASP B CA  1 
ATOM   2073 C C   . ASP B 1 10  ? 85.95000 78.19100 -39.11400 1.000 44.34000 ? 54  ASP B C   1 
ATOM   2074 O O   . ASP B 1 10  ? 86.63600 78.56300 -38.15100 1.000 45.55000 ? 54  ASP B O   1 
ATOM   2075 C CB  . ASP B 1 10  ? 87.21700 78.82400 -41.18800 1.000 48.08000 ? 54  ASP B CB  1 
ATOM   2076 C CG  . ASP B 1 10  ? 87.16500 79.48000 -42.55700 1.000 48.27000 ? 54  ASP B CG  1 
ATOM   2077 O OD1 . ASP B 1 10  ? 86.06700 79.53900 -43.15200 1.000 44.92000 ? 54  ASP B OD1 1 
ATOM   2078 O OD2 . ASP B 1 10  ? 88.22300 79.93600 -43.03900 1.000 54.21000 ? 54  ASP B OD2 1 
ATOM   2079 N N   . PRO B 1 11  ? 85.23000 77.07700 -39.06100 1.000 44.74000 ? 55  PRO B N   1 
ATOM   2080 C CA  . PRO B 1 11  ? 84.97900 76.41200 -37.78000 1.000 43.82000 ? 55  PRO B CA  1 
ATOM   2081 C C   . PRO B 1 11  ? 86.15600 75.57900 -37.29600 1.000 45.09000 ? 55  PRO B C   1 
ATOM   2082 O O   . PRO B 1 11  ? 87.00600 75.12500 -38.06400 1.000 45.47000 ? 55  PRO B O   1 
ATOM   2083 C CB  . PRO B 1 11  ? 83.77500 75.51800 -38.08700 1.000 41.86000 ? 55  PRO B CB  1 
ATOM   2084 C CG  . PRO B 1 11  ? 83.93900 75.18200 -39.53100 1.000 40.88000 ? 55  PRO B CG  1 
ATOM   2085 C CD  . PRO B 1 11  ? 84.54800 76.40200 -40.17900 1.000 42.92000 ? 55  PRO B CD  1 
ATOM   2086 N N   . THR B 1 12  ? 86.18600 75.39300 -35.97800 1.000 44.21000 ? 56  THR B N   1 
ATOM   2087 C CA  . THR B 1 12  ? 87.09700 74.48200 -35.30600 1.000 41.29000 ? 56  THR B CA  1 
ATOM   2088 C C   . THR B 1 12  ? 86.30500 73.69100 -34.27700 1.000 37.82000 ? 56  THR B C   1 
ATOM   2089 O O   . THR B 1 12  ? 85.13100 73.97100 -34.02000 1.000 39.75000 ? 56  THR B O   1 
ATOM   2090 C CB  . THR B 1 12  ? 88.24800 75.22400 -34.61400 1.000 43.83000 ? 56  THR B CB  1 
ATOM   2091 O OG1 . THR B 1 12  ? 87.73400 75.97500 -33.50700 1.000 44.34000 ? 56  THR B OG1 1 
ATOM   2092 C CG2 . THR B 1 12  ? 88.92700 76.17000 -35.57800 1.000 49.21000 ? 56  THR B CG2 1 
ATOM   2093 N N   . GLU B 1 13  ? 86.95400 72.69300 -33.67600 1.000 37.96000 ? 57  GLU B N   1 
ATOM   2094 C CA  . GLU B 1 13  ? 86.30100 71.98700 -32.58000 1.000 40.06000 ? 57  GLU B CA  1 
ATOM   2095 C C   . GLU B 1 13  ? 86.19300 72.87200 -31.34600 1.000 39.35000 ? 57  GLU B C   1 
ATOM   2096 O O   . GLU B 1 13  ? 85.24700 72.73200 -30.56500 1.000 40.71000 ? 57  GLU B O   1 
ATOM   2097 C CB  . GLU B 1 13  ? 87.04400 70.69000 -32.25400 1.000 42.22000 ? 57  GLU B CB  1 
ATOM   2098 C CG  . GLU B 1 13  ? 86.19600 69.68500 -31.48000 1.000 41.17000 ? 57  GLU B CG  1 
ATOM   2099 C CD  . GLU B 1 13  ? 86.91600 68.37600 -31.22100 1.000 44.76000 ? 57  GLU B CD  1 
ATOM   2100 O OE1 . GLU B 1 13  ? 87.83900 68.35600 -30.37900 1.000 49.54000 ? 57  GLU B OE1 1 
ATOM   2101 O OE2 . GLU B 1 13  ? 86.56100 67.36500 -31.86400 1.000 46.01000 ? 57  GLU B OE2 1 
ATOM   2102 N N   . ASP B 1 14  ? 87.13700 73.80000 -31.16600 1.000 39.99000 ? 58  ASP B N   1 
ATOM   2103 C CA  . ASP B 1 14  ? 87.04500 74.74600 -30.05800 1.000 41.29000 ? 58  ASP B CA  1 
ATOM   2104 C C   . ASP B 1 14  ? 85.85000 75.67700 -30.22200 1.000 40.18000 ? 58  ASP B C   1 
ATOM   2105 O O   . ASP B 1 14  ? 85.15300 75.98100 -29.24800 1.000 43.91000 ? 58  ASP B O   1 
ATOM   2106 C CB  . ASP B 1 14  ? 88.33900 75.55400 -29.94900 1.000 44.86000 ? 58  ASP B CB  1 
ATOM   2107 C CG  . ASP B 1 14  ? 89.42700 74.81700 -29.19300 1.000 48.90000 ? 58  ASP B CG  1 
ATOM   2108 O OD1 . ASP B 1 14  ? 89.08700 73.97800 -28.33300 1.000 47.92000 ? 58  ASP B OD1 1 
ATOM   2109 O OD2 . ASP B 1 14  ? 90.62000 75.08300 -29.45100 1.000 54.18000 ? 58  ASP B OD2 1 
ATOM   2110 N N   . SER B 1 15  ? 85.59400 76.13300 -31.45200 1.000 41.23000 ? 59  SER B N   1 
ATOM   2111 C CA  . SER B 1 15  ? 84.52500 77.09800 -31.69500 1.000 39.63000 ? 59  SER B CA  1 
ATOM   2112 C C   . SER B 1 15  ? 83.14500 76.45800 -31.60400 1.000 38.45000 ? 59  SER B C   1 
ATOM   2113 O O   . SER B 1 15  ? 82.20100 77.09200 -31.12000 1.000 38.11000 ? 59  SER B O   1 
ATOM   2114 C CB  . SER B 1 15  ? 84.70800 77.76200 -33.06200 1.000 40.65000 ? 59  SER B CB  1 
ATOM   2115 O OG  . SER B 1 15  ? 84.20100 76.94900 -34.10800 1.000 38.65000 ? 59  SER B OG  1 
ATOM   2116 N N   . ILE B 1 16  ? 83.00300 75.21300 -32.06500 1.000 36.49000 ? 60  ILE B N   1 
ATOM   2117 C CA  . ILE B 1 16  ? 81.71000 74.54300 -31.97400 1.000 35.53000 ? 60  ILE B CA  1 
ATOM   2118 C C   . ILE B 1 16  ? 81.43700 74.01300 -30.57200 1.000 36.52000 ? 60  ILE B C   1 
ATOM   2119 O O   . ILE B 1 16  ? 80.26900 73.83600 -30.20200 1.000 32.37000 ? 60  ILE B O   1 
ATOM   2120 C CB  . ILE B 1 16  ? 81.60600 73.40200 -33.00000 1.000 35.62000 ? 60  ILE B CB  1 
ATOM   2121 C CG1 . ILE B 1 16  ? 82.64600 72.31700 -32.71600 1.000 35.33000 ? 60  ILE B CG1 1 
ATOM   2122 C CG2 . ILE B 1 16  ? 81.78000 73.94000 -34.40800 1.000 37.23000 ? 60  ILE B CG2 1 
ATOM   2123 C CD1 . ILE B 1 16  ? 82.53500 71.11200 -33.62600 1.000 32.73000 ? 60  ILE B CD1 1 
ATOM   2124 N N   . GLU B 1 17  ? 82.47700 73.75600 -29.78000 1.000 36.89000 ? 61  GLU B N   1 
ATOM   2125 C CA  . GLU B 1 17  ? 82.29500 73.36500 -28.38900 1.000 37.91000 ? 61  GLU B CA  1 
ATOM   2126 C C   . GLU B 1 17  ? 82.13700 74.55900 -27.45900 1.000 37.79000 ? 61  GLU B C   1 
ATOM   2127 O O   . GLU B 1 17  ? 81.88000 74.36400 -26.26600 1.000 38.88000 ? 61  GLU B O   1 
ATOM   2128 C CB  . GLU B 1 17  ? 83.47500 72.51100 -27.91700 1.000 36.96000 ? 61  GLU B CB  1 
ATOM   2129 C CG  . GLU B 1 17  ? 83.53100 71.11500 -28.51300 1.000 33.05000 ? 61  GLU B CG  1 
ATOM   2130 C CD  . GLU B 1 17  ? 84.73700 70.33700 -28.03000 1.000 34.96000 ? 61  GLU B CD  1 
ATOM   2131 O OE1 . GLU B 1 17  ? 85.73000 70.97600 -27.62500 1.000 39.54000 ? 61  GLU B OE1 1 
ATOM   2132 O OE2 . GLU B 1 17  ? 84.69100 69.08900 -28.04800 1.000 34.29000 ? 61  GLU B OE2 1 
ATOM   2133 N N   . ALA B 1 18  ? 82.27600 75.77800 -27.97200 1.000 35.57000 ? 62  ALA B N   1 
ATOM   2134 C CA  . ALA B 1 18  ? 82.23000 76.96200 -27.12800 1.000 34.33000 ? 62  ALA B CA  1 
ATOM   2135 C C   . ALA B 1 18  ? 80.81100 77.23300 -26.64800 1.000 38.22000 ? 62  ALA B C   1 
ATOM   2136 O O   . ALA B 1 18  ? 79.83800 77.02100 -27.37800 1.000 39.58000 ? 62  ALA B O   1 
ATOM   2137 C CB  . ALA B 1 18  ? 82.76600 78.17500 -27.88800 1.000 34.72000 ? 62  ALA B CB  1 
ATOM   2138 N N   . ILE B 1 19  ? 80.69700 77.70900 -25.40600 1.000 38.03000 ? 63  ILE B N   1 
ATOM   2139 C CA  . ILE B 1 19  ? 79.38900 78.06200 -24.86200 1.000 34.85000 ? 63  ILE B CA  1 
ATOM   2140 C C   . ILE B 1 19  ? 78.77900 79.21300 -25.64600 1.000 37.80000 ? 63  ILE B C   1 
ATOM   2141 O O   . ILE B 1 19  ? 77.55600 79.28300 -25.81900 1.000 38.10000 ? 63  ILE B O   1 
ATOM   2142 C CB  . ILE B 1 19  ? 79.51900 78.39900 -23.36300 1.000 35.13000 ? 63  ILE B CB  1 
ATOM   2143 C CG1 . ILE B 1 19  ? 80.02300 77.18000 -22.59100 1.000 35.88000 ? 63  ILE B CG1 1 
ATOM   2144 C CG2 . ILE B 1 19  ? 78.19000 78.87400 -22.79700 1.000 37.27000 ? 63  ILE B CG2 1 
ATOM   2145 C CD1 . ILE B 1 19  ? 80.22700 77.44000 -21.12200 1.000 42.72000 ? 63  ILE B CD1 1 
ATOM   2146 N N   . ARG B 1 20  ? 79.61200 80.12100 -26.14300 1.000 39.44000 ? 64  ARG B N   1 
ATOM   2147 C CA  . ARG B 1 20  ? 79.16500 81.25300 -26.93900 1.000 40.01000 ? 64  ARG B CA  1 
ATOM   2148 C C   . ARG B 1 20  ? 79.83200 81.19700 -28.30300 1.000 40.91000 ? 64  ARG B C   1 
ATOM   2149 O O   . ARG B 1 20  ? 81.05200 81.02500 -28.39600 1.000 41.84000 ? 64  ARG B O   1 
ATOM   2150 C CB  . ARG B 1 20  ? 79.49200 82.57900 -26.25000 1.000 43.55000 ? 64  ARG B CB  1 
ATOM   2151 C CG  . ARG B 1 20  ? 78.94300 82.70000 -24.84500 1.000 50.24000 ? 64  ARG B CG  1 
ATOM   2152 C CD  . ARG B 1 20  ? 79.31300 84.03800 -24.23500 1.000 55.22000 ? 64  ARG B CD  1 
ATOM   2153 N NE  . ARG B 1 20  ? 78.90800 84.12600 -22.83800 1.000 62.57000 ? 64  ARG B NE  1 
ATOM   2154 C CZ  . ARG B 1 20  ? 77.70900 84.52000 -22.43000 1.000 66.03000 ? 64  ARG B CZ  1 
ATOM   2155 N NH1 . ARG B 1 20  ? 76.77000 84.87800 -23.29000 1.000 60.58000 ? 64  ARG B NH1 1 
ATOM   2156 N NH2 . ARG B 1 20  ? 77.44600 84.55300 -21.12700 1.000 68.60000 ? 64  ARG B NH2 1 
ATOM   2157 N N   . GLY B 1 21  ? 79.03300 81.33800 -29.35600 1.000 39.88000 ? 65  GLY B N   1 
ATOM   2158 C CA  . GLY B 1 21  ? 79.55500 81.40800 -30.69600 1.000 39.65000 ? 65  GLY B CA  1 
ATOM   2159 C C   . GLY B 1 21  ? 80.11800 82.78100 -30.99700 1.000 42.13000 ? 65  GLY B C   1 
ATOM   2160 O O   . GLY B 1 21  ? 80.27800 83.62200 -30.10700 1.000 44.10000 ? 65  GLY B O   1 
ATOM   2161 N N   . PRO B 1 22  ? 80.43100 83.03700 -32.26800 1.000 43.50000 ? 66  PRO B N   1 
ATOM   2162 C CA  . PRO B 1 22  ? 80.99600 84.34700 -32.62300 1.000 44.71000 ? 66  PRO B CA  1 
ATOM   2163 C C   . PRO B 1 22  ? 80.00400 85.49100 -32.50000 1.000 44.57000 ? 66  PRO B C   1 
ATOM   2164 O O   . PRO B 1 22  ? 80.41500 86.62000 -32.20800 1.000 48.79000 ? 66  PRO B O   1 
ATOM   2165 C CB  . PRO B 1 22  ? 81.45100 84.14900 -34.07600 1.000 45.49000 ? 66  PRO B CB  1 
ATOM   2166 C CG  . PRO B 1 22  ? 80.58400 83.04700 -34.59100 1.000 45.42000 ? 66  PRO B CG  1 
ATOM   2167 C CD  . PRO B 1 22  ? 80.35500 82.12900 -33.42600 1.000 44.81000 ? 66  PRO B CD  1 
ATOM   2168 N N   . PHE B 1 23  ? 78.71700 85.23800 -32.70200 1.000 42.84000 ? 67  PHE B N   1 
ATOM   2169 C CA  . PHE B 1 23  ? 77.73000 86.30500 -32.75000 1.000 45.19000 ? 67  PHE B CA  1 
ATOM   2170 C C   . PHE B 1 23  ? 77.21700 86.65000 -31.35600 1.000 46.66000 ? 67  PHE B C   1 
ATOM   2171 O O   . PHE B 1 23  ? 77.30500 85.85800 -30.41500 1.000 48.01000 ? 67  PHE B O   1 
ATOM   2172 C CB  . PHE B 1 23  ? 76.55400 85.91100 -33.64400 1.000 44.98000 ? 67  PHE B CB  1 
ATOM   2173 C CG  . PHE B 1 23  ? 76.92700 85.67600 -35.07900 1.000 46.19000 ? 67  PHE B CG  1 
ATOM   2174 C CD1 . PHE B 1 23  ? 77.40800 84.44400 -35.49300 1.000 44.23000 ? 67  PHE B CD1 1 
ATOM   2175 C CD2 . PHE B 1 23  ? 76.78000 86.68200 -36.01900 1.000 48.23000 ? 67  PHE B CD2 1 
ATOM   2176 C CE1 . PHE B 1 23  ? 77.74700 84.22500 -36.81400 1.000 43.30000 ? 67  PHE B CE1 1 
ATOM   2177 C CE2 . PHE B 1 23  ? 77.11600 86.46800 -37.34200 1.000 45.31000 ? 67  PHE B CE2 1 
ATOM   2178 C CZ  . PHE B 1 23  ? 77.60000 85.23800 -37.73900 1.000 44.49000 ? 67  PHE B CZ  1 
ATOM   2179 N N   . SER B 1 24  ? 76.67100 87.85700 -31.23900 1.000 44.84000 ? 68  SER B N   1 
ATOM   2180 C CA  . SER B 1 24  ? 75.93900 88.28200 -30.05700 1.000 44.48000 ? 68  SER B CA  1 
ATOM   2181 C C   . SER B 1 24  ? 74.44500 88.11200 -30.30400 1.000 44.98000 ? 68  SER B C   1 
ATOM   2182 O O   . SER B 1 24  ? 73.97400 88.19300 -31.44100 1.000 44.50000 ? 68  SER B O   1 
ATOM   2183 C CB  . SER B 1 24  ? 76.25700 89.73600 -29.70300 1.000 43.80000 ? 68  SER B CB  1 
ATOM   2184 O OG  . SER B 1 24  ? 75.90100 90.60900 -30.76000 1.000 48.51000 ? 68  SER B OG  1 
ATOM   2185 N N   . VAL B 1 25  ? 73.70100 87.87300 -29.22800 1.000 43.22000 ? 69  VAL B N   1 
ATOM   2186 C CA  . VAL B 1 25  ? 72.30300 87.46800 -29.31500 1.000 44.31000 ? 69  VAL B CA  1 
ATOM   2187 C C   . VAL B 1 25  ? 71.43100 88.51500 -28.63700 1.000 44.50000 ? 69  VAL B C   1 
ATOM   2188 O O   . VAL B 1 25  ? 71.74800 88.97900 -27.53500 1.000 45.34000 ? 69  VAL B O   1 
ATOM   2189 C CB  . VAL B 1 25  ? 72.07900 86.08200 -28.68200 1.000 42.71000 ? 69  VAL B CB  1 
ATOM   2190 C CG1 . VAL B 1 25  ? 70.62900 85.65200 -28.83400 1.000 43.14000 ? 69  VAL B CG1 1 
ATOM   2191 C CG2 . VAL B 1 25  ? 73.01100 85.05800 -29.30700 1.000 41.42000 ? 69  VAL B CG2 1 
ATOM   2192 N N   . ALA B 1 26  ? 70.33800 88.88300 -29.30000 1.000 42.87000 ? 70  ALA B N   1 
ATOM   2193 C CA  . ALA B 1 26  ? 69.27100 89.67900 -28.71400 1.000 41.05000 ? 70  ALA B CA  1 
ATOM   2194 C C   . ALA B 1 26  ? 68.00800 88.83100 -28.66900 1.000 41.84000 ? 70  ALA B C   1 
ATOM   2195 O O   . ALA B 1 26  ? 67.73600 88.06100 -29.59500 1.000 41.67000 ? 70  ALA B O   1 
ATOM   2196 C CB  . ALA B 1 26  ? 69.02400 90.96100 -29.51400 1.000 40.65000 ? 70  ALA B CB  1 
ATOM   2197 N N   . THR B 1 27  ? 67.24300 88.96500 -27.59100 1.000 41.80000 ? 71  THR B N   1 
ATOM   2198 C CA  . THR B 1 27  ? 66.08300 88.12000 -27.36100 1.000 36.70000 ? 71  THR B CA  1 
ATOM   2199 C C   . THR B 1 27  ? 64.79300 88.87900 -27.67000 1.000 36.66000 ? 71  THR B C   1 
ATOM   2200 O O   . THR B 1 27  ? 64.79400 90.07600 -27.96500 1.000 38.50000 ? 71  THR B O   1 
ATOM   2201 C CB  . THR B 1 27  ? 66.07900 87.60200 -25.92300 1.000 37.45000 ? 71  THR B CB  1 
ATOM   2202 O OG1 . THR B 1 27  ? 66.01700 88.71000 -25.01800 1.000 44.86000 ? 71  THR B OG1 1 
ATOM   2203 C CG2 . THR B 1 27  ? 67.34000 86.80100 -25.64800 1.000 36.44000 ? 71  THR B CG2 1 
ATOM   2204 N N   . GLU B 1 28  ? 63.67400 88.16100 -27.59100 1.000 34.81000 ? 72  GLU B N   1 
ATOM   2205 C CA  . GLU B 1 28  ? 62.35800 88.71500 -27.87700 1.000 34.80000 ? 72  GLU B CA  1 
ATOM   2206 C C   . GLU B 1 28  ? 61.30300 87.71700 -27.42300 1.000 33.66000 ? 72  GLU B C   1 
ATOM   2207 O O   . GLU B 1 28  ? 61.48300 86.50900 -27.58300 1.000 35.81000 ? 72  GLU B O   1 
ATOM   2208 C CB  . GLU B 1 28  ? 62.20300 89.02000 -29.37200 1.000 36.75000 ? 72  GLU B CB  1 
ATOM   2209 C CG  . GLU B 1 28  ? 60.80000 89.40500 -29.79100 1.000 38.98000 ? 72  GLU B CG  1 
ATOM   2210 C CD  . GLU B 1 28  ? 60.73200 89.86100 -31.23100 1.000 44.57000 ? 72  GLU B CD  1 
ATOM   2211 O OE1 . GLU B 1 28  ? 61.55400 90.71400 -31.62500 1.000 48.56000 ? 72  GLU B OE1 1 
ATOM   2212 O OE2 . GLU B 1 28  ? 59.86100 89.36000 -31.97200 1.000 45.77000 ? 72  GLU B OE2 1 
ATOM   2213 N N   . ARG B 1 29  ? 60.21000 88.22300 -26.85900 1.000 35.55000 ? 73  ARG B N   1 
ATOM   2214 C CA  . ARG B 1 29  ? 59.14200 87.38400 -26.33200 1.000 34.76000 ? 73  ARG B CA  1 
ATOM   2215 C C   . ARG B 1 29  ? 57.93700 87.43500 -27.25800 1.000 32.44000 ? 73  ARG B C   1 
ATOM   2216 O O   . ARG B 1 29  ? 57.50300 88.51900 -27.66000 1.000 36.13000 ? 73  ARG B O   1 
ATOM   2217 C CB  . ARG B 1 29  ? 58.73700 87.83400 -24.92800 1.000 37.49000 ? 73  ARG B CB  1 
ATOM   2218 C CG  . ARG B 1 29  ? 59.90400 88.14300 -24.01800 1.000 39.18000 ? 73  ARG B CG  1 
ATOM   2219 C CD  . ARG B 1 29  ? 60.77000 86.92200 -23.80000 1.000 39.27000 ? 73  ARG B CD  1 
ATOM   2220 N NE  . ARG B 1 29  ? 61.44100 86.97700 -22.50800 1.000 49.39000 ? 73  ARG B NE  1 
ATOM   2221 C CZ  . ARG B 1 29  ? 60.88800 86.58600 -21.36800 1.000 51.08000 ? 73  ARG B CZ  1 
ATOM   2222 N NH1 . ARG B 1 29  ? 59.65800 86.10100 -21.32700 1.000 49.33000 ? 73  ARG B NH1 1 
ATOM   2223 N NH2 . ARG B 1 29  ? 61.58700 86.68300 -20.24100 1.000 53.73000 ? 73  ARG B NH2 1 
ATOM   2224 N N   . VAL B 1 30  ? 57.39600 86.26600 -27.58700 1.000 29.20000 ? 74  VAL B N   1 
ATOM   2225 C CA  . VAL B 1 30  ? 56.16400 86.15200 -28.35700 1.000 30.31000 ? 74  VAL B CA  1 
ATOM   2226 C C   . VAL B 1 30  ? 55.06400 85.69200 -27.41300 1.000 27.79000 ? 74  VAL B C   1 
ATOM   2227 O O   . VAL B 1 30  ? 55.22700 84.69600 -26.69800 1.000 31.02000 ? 74  VAL B O   1 
ATOM   2228 C CB  . VAL B 1 30  ? 56.32300 85.18700 -29.54400 1.000 30.08000 ? 74  VAL B CB  1 
ATOM   2229 C CG1 . VAL B 1 30  ? 55.03600 85.12500 -30.34900 1.000 30.92000 ? 74  VAL B CG1 1 
ATOM   2230 C CG2 . VAL B 1 30  ? 57.47800 85.62600 -30.41800 1.000 31.12000 ? 74  VAL B CG2 1 
ATOM   2231 N N   . SER B 1 31  ? 53.95200 86.42300 -27.40600 1.000 25.10000 ? 75  SER B N   1 
ATOM   2232 C CA  . SER B 1 31  ? 52.87200 86.13700 -26.47200 1.000 27.76000 ? 75  SER B CA  1 
ATOM   2233 C C   . SER B 1 31  ? 52.28900 84.75100 -26.71800 1.000 28.67000 ? 75  SER B C   1 
ATOM   2234 O O   . SER B 1 31  ? 52.30800 84.23100 -27.83700 1.000 28.39000 ? 75  SER B O   1 
ATOM   2235 C CB  . SER B 1 31  ? 51.77400 87.19000 -26.59100 1.000 25.71000 ? 75  SER B CB  1 
ATOM   2236 O OG  . SER B 1 31  ? 50.56700 86.72600 -26.01300 1.000 29.12000 ? 75  SER B OG  1 
ATOM   2237 N N   . SER B 1 32  ? 51.75800 84.15600 -25.65000 1.000 26.00000 ? 76  SER B N   1 
ATOM   2238 C CA  . SER B 1 32  ? 51.16900 82.82600 -25.73800 1.000 26.93000 ? 76  SER B CA  1 
ATOM   2239 C C   . SER B 1 32  ? 49.87800 82.80400 -26.54400 1.000 26.15000 ? 76  SER B C   1 
ATOM   2240 O O   . SER B 1 32  ? 49.36500 81.71600 -26.82700 1.000 25.27000 ? 76  SER B O   1 
ATOM   2241 C CB  . SER B 1 32  ? 50.90700 82.27500 -24.33600 1.000 27.52000 ? 76  SER B CB  1 
ATOM   2242 O OG  . SER B 1 32  ? 49.99100 83.09400 -23.63000 1.000 27.71000 ? 76  SER B OG  1 
ATOM   2243 N N   . PHE B 1 33  ? 49.34100 83.96400 -26.91200 1.000 27.26000 ? 77  PHE B N   1 
ATOM   2244 C CA  . PHE B 1 33  ? 48.11600 84.04300 -27.69200 1.000 26.88000 ? 77  PHE B CA  1 
ATOM   2245 C C   . PHE B 1 33  ? 48.38400 84.15300 -29.18400 1.000 28.76000 ? 77  PHE B C   1 
ATOM   2246 O O   . PHE B 1 33  ? 47.46200 84.45200 -29.95000 1.000 30.01000 ? 77  PHE B O   1 
ATOM   2247 C CB  . PHE B 1 33  ? 47.26700 85.22000 -27.21600 1.000 26.61000 ? 77  PHE B CB  1 
ATOM   2248 C CG  . PHE B 1 33  ? 46.88400 85.13400 -25.77000 1.000 26.44000 ? 77  PHE B CG  1 
ATOM   2249 C CD1 . PHE B 1 33  ? 45.88900 84.26500 -25.35700 1.000 26.22000 ? 77  PHE B CD1 1 
ATOM   2250 C CD2 . PHE B 1 33  ? 47.52300 85.91500 -24.82300 1.000 27.76000 ? 77  PHE B CD2 1 
ATOM   2251 C CE1 . PHE B 1 33  ? 45.53400 84.17900 -24.02700 1.000 27.66000 ? 77  PHE B CE1 1 
ATOM   2252 C CE2 . PHE B 1 33  ? 47.17200 85.83500 -23.48900 1.000 27.09000 ? 77  PHE B CE2 1 
ATOM   2253 C CZ  . PHE B 1 33  ? 46.17600 84.96600 -23.09100 1.000 26.96000 ? 77  PHE B CZ  1 
ATOM   2254 N N   . ALA B 1 34  ? 49.62500 83.93200 -29.61000 1.000 28.22000 ? 78  ALA B N   1 
ATOM   2255 C CA  . ALA B 1 34  ? 49.91200 83.82600 -31.03200 1.000 28.54000 ? 78  ALA B CA  1 
ATOM   2256 C C   . ALA B 1 34  ? 49.13500 82.65900 -31.62200 1.000 30.17000 ? 78  ALA B C   1 
ATOM   2257 O O   . ALA B 1 34  ? 48.96600 81.61700 -30.98300 1.000 29.29000 ? 78  ALA B O   1 
ATOM   2258 C CB  . ALA B 1 34  ? 51.41200 83.64400 -31.26200 1.000 26.98000 ? 78  ALA B CB  1 
ATOM   2259 N N   . SER B 1 35  ? 48.64800 82.84300 -32.84400 1.000 31.94000 ? 79  SER B N   1 
ATOM   2260 C CA  . SER B 1 35  ? 47.77800 81.84800 -33.45600 1.000 29.51000 ? 79  SER B CA  1 
ATOM   2261 C C   . SER B 1 35  ? 48.55700 80.57800 -33.78100 1.000 27.09000 ? 79  SER B C   1 
ATOM   2262 O O   . SER B 1 35  ? 49.58700 80.62200 -34.46200 1.000 31.99000 ? 79  SER B O   1 
ATOM   2263 C CB  . SER B 1 35  ? 47.13600 82.42200 -34.71800 1.000 29.64000 ? 79  SER B CB  1 
ATOM   2264 O OG  . SER B 1 35  ? 46.16500 81.53700 -35.24600 1.000 37.00000 ? 79  SER B OG  1 
ATOM   2265 N N   . GLY B 1 36  ? 48.06800 79.44300 -33.27600 1.000 26.75000 ? 80  GLY B N   1 
ATOM   2266 C CA  . GLY B 1 36  ? 48.57500 78.13700 -33.62300 1.000 28.38000 ? 80  GLY B CA  1 
ATOM   2267 C C   . GLY B 1 36  ? 49.48400 77.50100 -32.58900 1.000 25.59000 ? 80  GLY B C   1 
ATOM   2268 O O   . GLY B 1 36  ? 49.60000 76.27100 -32.56000 1.000 26.54000 ? 80  GLY B O   1 
ATOM   2269 N N   . PHE B 1 37  ? 50.13700 78.30200 -31.75100 1.000 27.28000 ? 81  PHE B N   1 
ATOM   2270 C CA  . PHE B 1 37  ? 51.06900 77.77300 -30.76500 1.000 26.02000 ? 81  PHE B CA  1 
ATOM   2271 C C   . PHE B 1 37  ? 51.09100 78.69400 -29.55300 1.000 26.77000 ? 81  PHE B C   1 
ATOM   2272 O O   . PHE B 1 37  ? 50.52100 79.78800 -29.56500 1.000 27.54000 ? 81  PHE B O   1 
ATOM   2273 C CB  . PHE B 1 37  ? 52.47400 77.59900 -31.35400 1.000 24.84000 ? 81  PHE B CB  1 
ATOM   2274 C CG  . PHE B 1 37  ? 53.18500 78.89200 -31.63900 1.000 25.13000 ? 81  PHE B CG  1 
ATOM   2275 C CD1 . PHE B 1 37  ? 52.73900 79.74400 -32.63700 1.000 25.95000 ? 81  PHE B CD1 1 
ATOM   2276 C CD2 . PHE B 1 37  ? 54.31600 79.24600 -30.92300 1.000 24.72000 ? 81  PHE B CD2 1 
ATOM   2277 C CE1 . PHE B 1 37  ? 53.39700 80.93000 -32.90300 1.000 25.14000 ? 81  PHE B CE1 1 
ATOM   2278 C CE2 . PHE B 1 37  ? 54.98000 80.42900 -31.18600 1.000 24.53000 ? 81  PHE B CE2 1 
ATOM   2279 C CZ  . PHE B 1 37  ? 54.52000 81.27200 -32.17700 1.000 25.29000 ? 81  PHE B CZ  1 
ATOM   2280 N N   . GLY B 1 38  ? 51.76500 78.23500 -28.50000 1.000 28.01000 ? 82  GLY B N   1 
ATOM   2281 C CA  . GLY B 1 38  ? 51.74800 78.92500 -27.22500 1.000 26.71000 ? 82  GLY B CA  1 
ATOM   2282 C C   . GLY B 1 38  ? 52.87200 79.91900 -27.01600 1.000 26.82000 ? 82  GLY B C   1 
ATOM   2283 O O   . GLY B 1 38  ? 53.36000 80.07800 -25.89300 1.000 27.73000 ? 82  GLY B O   1 
ATOM   2284 N N   . GLY B 1 39  ? 53.28400 80.60200 -28.08100 1.000 26.60000 ? 83  GLY B N   1 
ATOM   2285 C CA  . GLY B 1 39  ? 54.32200 81.60300 -27.95000 1.000 25.26000 ? 83  GLY B CA  1 
ATOM   2286 C C   . GLY B 1 39  ? 55.68700 80.98800 -27.68100 1.000 23.17000 ? 83  GLY B C   1 
ATOM   2287 O O   . GLY B 1 39  ? 55.92400 79.79400 -27.87900 1.000 24.29000 ? 83  GLY B O   1 
ATOM   2288 N N   . GLY B 1 40  ? 56.59500 81.83600 -27.21500 1.000 24.98000 ? 84  GLY B N   1 
ATOM   2289 C CA  . GLY B 1 40  ? 57.94200 81.39700 -26.90800 1.000 24.16000 ? 84  GLY B CA  1 
ATOM   2290 C C   . GLY B 1 40  ? 58.88900 82.58400 -26.86400 1.000 24.97000 ? 84  GLY B C   1 
ATOM   2291 O O   . GLY B 1 40  ? 58.46300 83.72900 -26.73200 1.000 30.12000 ? 84  GLY B O   1 
ATOM   2292 N N   . THR B 1 41  ? 60.17800 82.27400 -26.98300 1.000 26.94000 ? 85  THR B N   1 
ATOM   2293 C CA  . THR B 1 41  ? 61.24200 83.26800 -26.94100 1.000 29.04000 ? 85  THR B CA  1 
ATOM   2294 C C   . THR B 1 41  ? 62.08000 83.16300 -28.20700 1.000 28.87000 ? 85  THR B C   1 
ATOM   2295 O O   . THR B 1 41  ? 62.58400 82.08400 -28.53500 1.000 29.56000 ? 85  THR B O   1 
ATOM   2296 C CB  . THR B 1 41  ? 62.13100 83.07800 -25.70900 1.000 29.45000 ? 85  THR B CB  1 
ATOM   2297 O OG1 . THR B 1 41  ? 61.34200 83.21800 -24.52000 1.000 32.12000 ? 85  THR B OG1 1 
ATOM   2298 C CG2 . THR B 1 41  ? 63.25100 84.10800 -25.69300 1.000 32.22000 ? 85  THR B CG2 1 
ATOM   2299 N N   . ILE B 1 42  ? 62.23300 84.28200 -28.90900 1.000 30.95000 ? 86  ILE B N   1 
ATOM   2300 C CA  . ILE B 1 42  ? 63.02000 84.33300 -30.13700 1.000 30.71000 ? 86  ILE B CA  1 
ATOM   2301 C C   . ILE B 1 42  ? 64.45000 84.72200 -29.79000 1.000 32.71000 ? 86  ILE B C   1 
ATOM   2302 O O   . ILE B 1 42  ? 64.68400 85.75600 -29.15600 1.000 36.49000 ? 86  ILE B O   1 
ATOM   2303 C CB  . ILE B 1 42  ? 62.41400 85.32300 -31.14400 1.000 31.50000 ? 86  ILE B CB  1 
ATOM   2304 C CG1 . ILE B 1 42  ? 60.98900 84.91500 -31.51400 1.000 31.45000 ? 86  ILE B CG1 1 
ATOM   2305 C CG2 . ILE B 1 42  ? 63.28500 85.41000 -32.38800 1.000 36.34000 ? 86  ILE B CG2 1 
ATOM   2306 C CD1 . ILE B 1 42  ? 60.36600 85.79700 -32.57200 1.000 32.85000 ? 86  ILE B CD1 1 
ATOM   2307 N N   . TYR B 1 43  ? 65.40700 83.89700 -30.20700 1.000 32.52000 ? 87  TYR B N   1 
ATOM   2308 C CA  . TYR B 1 43  ? 66.83000 84.17200 -30.03800 1.000 33.25000 ? 87  TYR B CA  1 
ATOM   2309 C C   . TYR B 1 43  ? 67.42600 84.44000 -31.41500 1.000 36.99000 ? 87  TYR B C   1 
ATOM   2310 O O   . TYR B 1 43  ? 67.61100 83.51100 -32.20800 1.000 37.43000 ? 87  TYR B O   1 
ATOM   2311 C CB  . TYR B 1 43  ? 67.54200 83.00700 -29.35400 1.000 33.15000 ? 87  TYR B CB  1 
ATOM   2312 C CG  . TYR B 1 43  ? 67.04300 82.70300 -27.96100 1.000 33.96000 ? 87  TYR B CG  1 
ATOM   2313 C CD1 . TYR B 1 43  ? 67.53300 83.39300 -26.86000 1.000 34.27000 ? 87  TYR B CD1 1 
ATOM   2314 C CD2 . TYR B 1 43  ? 66.08700 81.72000 -27.74500 1.000 33.14000 ? 87  TYR B CD2 1 
ATOM   2315 C CE1 . TYR B 1 43  ? 67.08100 83.11500 -25.58300 1.000 35.65000 ? 87  TYR B CE1 1 
ATOM   2316 C CE2 . TYR B 1 43  ? 65.63000 81.43500 -26.47500 1.000 33.03000 ? 87  TYR B CE2 1 
ATOM   2317 C CZ  . TYR B 1 43  ? 66.12900 82.13400 -25.39800 1.000 36.02000 ? 87  TYR B CZ  1 
ATOM   2318 O OH  . TYR B 1 43  ? 65.67100 81.84800 -24.13300 1.000 33.00000 ? 87  TYR B OH  1 
ATOM   2319 N N   . TYR B 1 44  ? 67.72700 85.70600 -31.69900 1.000 39.27000 ? 88  TYR B N   1 
ATOM   2320 C CA  . TYR B 1 44  ? 68.25100 86.07600 -33.00200 1.000 39.19000 ? 88  TYR B CA  1 
ATOM   2321 C C   . TYR B 1 44  ? 69.58200 86.80300 -32.85500 1.000 41.12000 ? 88  TYR B C   1 
ATOM   2322 O O   . TYR B 1 44  ? 69.81500 87.48200 -31.84900 1.000 40.70000 ? 88  TYR B O   1 
ATOM   2323 C CB  . TYR B 1 44  ? 67.26300 86.96800 -33.76800 1.000 40.80000 ? 88  TYR B CB  1 
ATOM   2324 C CG  . TYR B 1 44  ? 67.00400 88.31400 -33.12700 1.000 41.54000 ? 88  TYR B CG  1 
ATOM   2325 C CD1 . TYR B 1 44  ? 65.99100 88.47700 -32.19200 1.000 41.33000 ? 88  TYR B CD1 1 
ATOM   2326 C CD2 . TYR B 1 44  ? 67.76500 89.42500 -33.46700 1.000 42.52000 ? 88  TYR B CD2 1 
ATOM   2327 C CE1 . TYR B 1 44  ? 65.75000 89.70700 -31.60700 1.000 42.44000 ? 88  TYR B CE1 1 
ATOM   2328 C CE2 . TYR B 1 44  ? 67.53400 90.65600 -32.88800 1.000 43.34000 ? 88  TYR B CE2 1 
ATOM   2329 C CZ  . TYR B 1 44  ? 66.52500 90.79200 -31.96000 1.000 43.12000 ? 88  TYR B CZ  1 
ATOM   2330 O OH  . TYR B 1 44  ? 66.29200 92.01800 -31.38300 1.000 45.38000 ? 88  TYR B OH  1 
ATOM   2331 N N   . PRO B 1 45  ? 70.47800 86.67200 -33.83000 1.000 42.77000 ? 89  PRO B N   1 
ATOM   2332 C CA  . PRO B 1 45  ? 71.74500 87.40700 -33.77000 1.000 43.38000 ? 89  PRO B CA  1 
ATOM   2333 C C   . PRO B 1 45  ? 71.53900 88.88400 -34.07000 1.000 42.70000 ? 89  PRO B C   1 
ATOM   2334 O O   . PRO B 1 45  ? 70.56300 89.29300 -34.70200 1.000 43.51000 ? 89  PRO B O   1 
ATOM   2335 C CB  . PRO B 1 45  ? 72.60600 86.73400 -34.84800 1.000 42.03000 ? 89  PRO B CB  1 
ATOM   2336 C CG  . PRO B 1 45  ? 71.87800 85.46500 -35.21100 1.000 38.93000 ? 89  PRO B CG  1 
ATOM   2337 C CD  . PRO B 1 45  ? 70.43400 85.75000 -34.97500 1.000 39.69000 ? 89  PRO B CD  1 
ATOM   2338 N N   . ARG B 1 46  ? 72.48600 89.69300 -33.60100 1.000 43.72000 ? 90  ARG B N   1 
ATOM   2339 C CA  . ARG B 1 46  ? 72.36300 91.13900 -33.73000 1.000 43.60000 ? 90  ARG B CA  1 
ATOM   2340 C C   . ARG B 1 46  ? 72.98300 91.67100 -35.01700 1.000 45.37000 ? 90  ARG B C   1 
ATOM   2341 O O   . ARG B 1 46  ? 72.39500 92.53900 -35.67000 1.000 45.39000 ? 90  ARG B O   1 
ATOM   2342 C CB  . ARG B 1 46  ? 73.00100 91.82800 -32.52100 1.000 47.48000 ? 90  ARG B CB  1 
ATOM   2343 C CG  . ARG B 1 46  ? 72.21900 91.64800 -31.22800 1.000 46.58000 ? 90  ARG B CG  1 
ATOM   2344 C CD  . ARG B 1 46  ? 73.04700 92.02500 -30.00900 1.000 46.78000 ? 90  ARG B CD  1 
ATOM   2345 N NE  . ARG B 1 46  ? 73.48300 93.41600 -30.03800 1.000 49.98000 ? 90  ARG B NE  1 
ATOM   2346 C CZ  . ARG B 1 46  ? 74.24600 93.98000 -29.11200 1.000 53.75000 ? 90  ARG B CZ  1 
ATOM   2347 N NH1 . ARG B 1 46  ? 74.67500 93.29900 -28.06200 1.000 54.77000 ? 90  ARG B NH1 1 
ATOM   2348 N NH2 . ARG B 1 46  ? 74.58900 95.25800 -29.24300 1.000 55.21000 ? 90  ARG B NH2 1 
ATOM   2349 N N   . GLU B 1 47  ? 74.15400 91.16700 -35.39800 1.000 47.07000 ? 91  GLU B N   1 
ATOM   2350 C CA  . GLU B 1 47  ? 74.87400 91.70000 -36.54600 1.000 46.74000 ? 91  GLU B CA  1 
ATOM   2351 C C   . GLU B 1 47  ? 74.22700 91.24300 -37.84600 1.000 44.47000 ? 91  GLU B C   1 
ATOM   2352 O O   . GLU B 1 47  ? 74.00400 90.04700 -38.05400 1.000 43.28000 ? 91  GLU B O   1 
ATOM   2353 C CB  . GLU B 1 47  ? 76.33700 91.26100 -36.51300 1.000 47.58000 ? 91  GLU B CB  1 
ATOM   2354 C CG  . GLU B 1 47  ? 77.07800 91.60800 -35.23200 1.000 48.33000 ? 91  GLU B CG  1 
ATOM   2355 C CD  . GLU B 1 47  ? 76.92600 90.54600 -34.16000 1.000 48.70000 ? 91  GLU B CD  1 
ATOM   2356 O OE1 . GLU B 1 47  ? 75.83800 89.93800 -34.06700 1.000 45.12000 ? 91  GLU B OE1 1 
ATOM   2357 O OE2 . GLU B 1 47  ? 77.90100 90.31300 -33.41400 1.000 51.01000 ? 91  GLU B OE2 1 
ATOM   2358 N N   . THR B 1 48  ? 73.93400 92.20100 -38.72600 1.000 48.57000 ? 92  THR B N   1 
ATOM   2359 C CA  . THR B 1 48  ? 73.43800 91.90500 -40.06400 1.000 49.76000 ? 92  THR B CA  1 
ATOM   2360 C C   . THR B 1 48  ? 74.49600 92.14900 -41.13300 1.000 49.56000 ? 92  THR B C   1 
ATOM   2361 O O   . THR B 1 48  ? 74.16100 92.25200 -42.31800 1.000 50.34000 ? 92  THR B O   1 
ATOM   2362 C CB  . THR B 1 48  ? 72.18300 92.72600 -40.36700 1.000 48.67000 ? 92  THR B CB  1 
ATOM   2363 O OG1 . THR B 1 48  ? 72.52300 94.11700 -40.43300 1.000 47.65000 ? 92  THR B OG1 1 
ATOM   2364 C CG2 . THR B 1 48  ? 71.13800 92.51800 -39.28300 1.000 50.12000 ? 92  THR B CG2 1 
ATOM   2365 N N   . ASP B 1 49  ? 75.76900 92.24700 -40.73600 1.000 51.43000 ? 93  ASP B N   1 
ATOM   2366 C CA  . ASP B 1 49  ? 76.83400 92.51300 -41.70000 1.000 51.40000 ? 93  ASP B CA  1 
ATOM   2367 C C   . ASP B 1 49  ? 76.96500 91.38700 -42.71400 1.000 51.39000 ? 93  ASP B C   1 
ATOM   2368 O O   . ASP B 1 49  ? 77.32200 91.62900 -43.87300 1.000 50.14000 ? 93  ASP B O   1 
ATOM   2369 C CB  . ASP B 1 49  ? 78.16400 92.71700 -40.97300 1.000 52.77000 ? 93  ASP B CB  1 
ATOM   2370 C CG  . ASP B 1 49  ? 78.12000 93.86100 -39.97800 1.000 62.21000 ? 93  ASP B CG  1 
ATOM   2371 O OD1 . ASP B 1 49  ? 77.35700 94.82200 -40.20700 1.000 63.38000 ? 93  ASP B OD1 1 
ATOM   2372 O OD2 . ASP B 1 49  ? 78.85200 93.80000 -38.96600 1.000 65.29000 ? 93  ASP B OD2 1 
ATOM   2373 N N   . GLU B 1 50  ? 76.67200 90.15800 -42.30100 1.000 48.89000 ? 94  GLU B N   1 
ATOM   2374 C CA  . GLU B 1 50  ? 76.90800 88.97600 -43.11100 1.000 44.77000 ? 94  GLU B CA  1 
ATOM   2375 C C   . GLU B 1 50  ? 75.65100 88.46800 -43.80500 1.000 45.12000 ? 94  GLU B C   1 
ATOM   2376 O O   . GLU B 1 50  ? 75.74200 87.54100 -44.61700 1.000 47.21000 ? 94  GLU B O   1 
ATOM   2377 C CB  . GLU B 1 50  ? 77.52300 87.87600 -42.24300 1.000 43.65000 ? 94  GLU B CB  1 
ATOM   2378 C CG  . GLU B 1 50  ? 78.71800 88.35900 -41.42400 1.000 44.15000 ? 94  GLU B CG  1 
ATOM   2379 C CD  . GLU B 1 50  ? 79.32800 87.26600 -40.57000 1.000 43.07000 ? 94  GLU B CD  1 
ATOM   2380 O OE1 . GLU B 1 50  ? 79.35200 86.10700 -41.03000 1.000 43.44000 ? 94  GLU B OE1 1 
ATOM   2381 O OE2 . GLU B 1 50  ? 79.77600 87.56200 -39.44000 1.000 48.85000 ? 94  GLU B OE2 1 
ATOM   2382 N N   . GLY B 1 51  ? 74.49400 89.04800 -43.51500 1.000 44.54000 ? 95  GLY B N   1 
ATOM   2383 C CA  . GLY B 1 51  ? 73.25900 88.72300 -44.19800 1.000 43.66000 ? 95  GLY B CA  1 
ATOM   2384 C C   . GLY B 1 51  ? 72.25000 88.08200 -43.26600 1.000 40.77000 ? 95  GLY B C   1 
ATOM   2385 O O   . GLY B 1 51  ? 72.45100 87.97700 -42.05900 1.000 42.16000 ? 95  GLY B O   1 
ATOM   2386 N N   . THR B 1 52  ? 71.14200 87.65200 -43.86600 1.000 42.09000 ? 96  THR B N   1 
ATOM   2387 C CA  . THR B 1 52  ? 70.08800 86.98900 -43.11800 1.000 40.43000 ? 96  THR B CA  1 
ATOM   2388 C C   . THR B 1 52  ? 70.52200 85.58200 -42.72100 1.000 41.19000 ? 96  THR B C   1 
ATOM   2389 O O   . THR B 1 52  ? 71.43700 84.99300 -43.30300 1.000 40.76000 ? 96  THR B O   1 
ATOM   2390 C CB  . THR B 1 52  ? 68.79600 86.92900 -43.93900 1.000 38.99000 ? 96  THR B CB  1 
ATOM   2391 O OG1 . THR B 1 52  ? 69.00900 86.14400 -45.11900 1.000 38.95000 ? 96  THR B OG1 1 
ATOM   2392 C CG2 . THR B 1 52  ? 68.35100 88.33000 -44.34000 1.000 39.76000 ? 96  THR B CG2 1 
ATOM   2393 N N   . PHE B 1 53  ? 69.85000 85.04500 -41.71000 1.000 40.33000 ? 97  PHE B N   1 
ATOM   2394 C CA  . PHE B 1 53  ? 70.18000 83.74500 -41.15200 1.000 39.24000 ? 97  PHE B CA  1 
ATOM   2395 C C   . PHE B 1 53  ? 69.00900 82.79000 -41.32600 1.000 37.45000 ? 97  PHE B C   1 
ATOM   2396 O O   . PHE B 1 53  ? 67.90100 83.18000 -41.70400 1.000 35.40000 ? 97  PHE B O   1 
ATOM   2397 C CB  . PHE B 1 53  ? 70.54000 83.85600 -39.66500 1.000 38.11000 ? 97  PHE B CB  1 
ATOM   2398 C CG  . PHE B 1 53  ? 71.60900 84.86500 -39.36900 1.000 38.68000 ? 97  PHE B CG  1 
ATOM   2399 C CD1 . PHE B 1 53  ? 71.28300 86.19000 -39.12900 1.000 39.31000 ? 97  PHE B CD1 1 
ATOM   2400 C CD2 . PHE B 1 53  ? 72.94000 84.48700 -39.31800 1.000 37.64000 ? 97  PHE B CD2 1 
ATOM   2401 C CE1 . PHE B 1 53  ? 72.26400 87.12000 -38.85200 1.000 38.61000 ? 97  PHE B CE1 1 
ATOM   2402 C CE2 . PHE B 1 53  ? 73.92700 85.41300 -39.04000 1.000 40.73000 ? 97  PHE B CE2 1 
ATOM   2403 C CZ  . PHE B 1 53  ? 73.58800 86.73100 -38.80600 1.000 41.28000 ? 97  PHE B CZ  1 
ATOM   2404 N N   . GLY B 1 54  ? 69.27600 81.51700 -41.03800 1.000 36.16000 ? 98  GLY B N   1 
ATOM   2405 C CA  . GLY B 1 54  ? 68.22500 80.52600 -40.96400 1.000 38.33000 ? 98  GLY B CA  1 
ATOM   2406 C C   . GLY B 1 54  ? 67.60400 80.46000 -39.57900 1.000 36.47000 ? 98  GLY B C   1 
ATOM   2407 O O   . GLY B 1 54  ? 68.14000 80.98300 -38.60300 1.000 34.77000 ? 98  GLY B O   1 
ATOM   2408 N N   . ALA B 1 55  ? 66.44900 79.80400 -39.50600 1.000 35.12000 ? 99  ALA B N   1 
ATOM   2409 C CA  . ALA B 1 55  ? 65.69400 79.68900 -38.26900 1.000 33.11000 ? 99  ALA B CA  1 
ATOM   2410 C C   . ALA B 1 55  ? 65.45800 78.22500 -37.92400 1.000 32.96000 ? 99  ALA B C   1 
ATOM   2411 O O   . ALA B 1 55  ? 65.35300 77.36800 -38.80600 1.000 33.00000 ? 99  ALA B O   1 
ATOM   2412 C CB  . ALA B 1 55  ? 64.34800 80.41600 -38.36700 1.000 30.72000 ? 99  ALA B CB  1 
ATOM   2413 N N   . VAL B 1 56  ? 65.37400 77.94900 -36.62300 1.000 33.70000 ? 100 VAL B N   1 
ATOM   2414 C CA  . VAL B 1 56  ? 65.06500 76.61600 -36.11800 1.000 29.43000 ? 100 VAL B CA  1 
ATOM   2415 C C   . VAL B 1 56  ? 64.09500 76.75900 -34.95300 1.000 27.45000 ? 100 VAL B C   1 
ATOM   2416 O O   . VAL B 1 56  ? 64.36400 77.49900 -34.00200 1.000 28.50000 ? 100 VAL B O   1 
ATOM   2417 C CB  . VAL B 1 56  ? 66.32800 75.84200 -35.69000 1.000 28.82000 ? 100 VAL B CB  1 
ATOM   2418 C CG1 . VAL B 1 56  ? 67.23300 76.71200 -34.82600 1.000 32.95000 ? 100 VAL B CG1 1 
ATOM   2419 C CG2 . VAL B 1 56  ? 65.94700 74.56100 -34.95800 1.000 27.96000 ? 100 VAL B CG2 1 
ATOM   2420 N N   . ALA B 1 57  ? 62.95900 76.07300 -35.04000 1.000 26.55000 ? 101 ALA B N   1 
ATOM   2421 C CA  . ALA B 1 57  ? 61.97500 76.05800 -33.96900 1.000 26.24000 ? 101 ALA B CA  1 
ATOM   2422 C C   . ALA B 1 57  ? 62.26700 74.89100 -33.03700 1.000 25.41000 ? 101 ALA B C   1 
ATOM   2423 O O   . ALA B 1 57  ? 62.47500 73.76100 -33.49100 1.000 25.55000 ? 101 ALA B O   1 
ATOM   2424 C CB  . ALA B 1 57  ? 60.55800 75.94900 -34.53300 1.000 26.22000 ? 101 ALA B CB  1 
ATOM   2425 N N   . VAL B 1 58  ? 62.29100 75.16700 -31.73500 1.000 25.81000 ? 102 VAL B N   1 
ATOM   2426 C CA  . VAL B 1 58  ? 62.64600 74.17700 -30.72500 1.000 22.78000 ? 102 VAL B CA  1 
ATOM   2427 C C   . VAL B 1 58  ? 61.41600 73.90400 -29.87300 1.000 22.49000 ? 102 VAL B C   1 
ATOM   2428 O O   . VAL B 1 58  ? 60.81400 74.83500 -29.32600 1.000 25.87000 ? 102 VAL B O   1 
ATOM   2429 C CB  . VAL B 1 58  ? 63.82900 74.64700 -29.86300 1.000 23.34000 ? 102 VAL B CB  1 
ATOM   2430 C CG1 . VAL B 1 58  ? 64.38200 73.48800 -29.05300 1.000 21.94000 ? 102 VAL B CG1 1 
ATOM   2431 C CG2 . VAL B 1 58  ? 64.91100 75.25000 -30.74000 1.000 24.50000 ? 102 VAL B CG2 1 
ATOM   2432 N N   . ALA B 1 59  ? 61.03900 72.62500 -29.76500 1.000 23.88000 ? 103 ALA B N   1 
ATOM   2433 C CA  . ALA B 1 59  ? 59.83500 72.25700 -29.03900 1.000 22.78000 ? 103 ALA B CA  1 
ATOM   2434 C C   . ALA B 1 59  ? 60.17100 71.43900 -27.79700 1.000 23.38000 ? 103 ALA B C   1 
ATOM   2435 O O   . ALA B 1 59  ? 61.08200 70.60300 -27.83300 1.000 21.22000 ? 103 ALA B O   1 
ATOM   2436 C CB  . ALA B 1 59  ? 58.87900 71.45100 -29.92700 1.000 23.00000 ? 103 ALA B CB  1 
ATOM   2437 N N   . PRO B 1 60  ? 59.46800 71.65700 -26.69100 1.000 25.53000 ? 104 PRO B N   1 
ATOM   2438 C CA  . PRO B 1 60  ? 59.67000 70.84000 -25.49200 1.000 23.20000 ? 104 PRO B CA  1 
ATOM   2439 C C   . PRO B 1 60  ? 58.87000 69.54300 -25.58700 1.000 23.98000 ? 104 PRO B C   1 
ATOM   2440 O O   . PRO B 1 60  ? 58.16800 69.28600 -26.56200 1.000 23.45000 ? 104 PRO B O   1 
ATOM   2441 C CB  . PRO B 1 60  ? 59.15000 71.74200 -24.37300 1.000 25.03000 ? 104 PRO B CB  1 
ATOM   2442 C CG  . PRO B 1 60  ? 58.06300 72.52500 -25.02900 1.000 22.89000 ? 104 PRO B CG  1 
ATOM   2443 C CD  . PRO B 1 60  ? 58.51100 72.75400 -26.45500 1.000 23.11000 ? 104 PRO B CD  1 
ATOM   2444 N N   . GLY B 1 61  ? 58.97900 68.72500 -24.53900 1.000 24.56000 ? 105 GLY B N   1 
ATOM   2445 C CA  . GLY B 1 61  ? 58.31200 67.44400 -24.48800 1.000 22.65000 ? 105 GLY B CA  1 
ATOM   2446 C C   . GLY B 1 61  ? 57.00100 67.49200 -23.72100 1.000 23.90000 ? 105 GLY B C   1 
ATOM   2447 O O   . GLY B 1 61  ? 56.47600 68.55300 -23.38000 1.000 27.04000 ? 105 GLY B O   1 
ATOM   2448 N N   . PHE B 1 62  ? 56.47300 66.30100 -23.44800 1.000 23.41000 ? 106 PHE B N   1 
ATOM   2449 C CA  . PHE B 1 62  ? 55.19000 66.17000 -22.76900 1.000 25.41000 ? 106 PHE B CA  1 
ATOM   2450 C C   . PHE B 1 62  ? 55.25900 66.74800 -21.36000 1.000 28.14000 ? 106 PHE B C   1 
ATOM   2451 O O   . PHE B 1 62  ? 56.18100 66.44700 -20.59800 1.000 28.25000 ? 106 PHE B O   1 
ATOM   2452 C CB  . PHE B 1 62  ? 54.78500 64.69700 -22.72600 1.000 24.53000 ? 106 PHE B CB  1 
ATOM   2453 C CG  . PHE B 1 62  ? 53.53000 64.42800 -21.95300 1.000 28.69000 ? 106 PHE B CG  1 
ATOM   2454 C CD1 . PHE B 1 62  ? 52.30200 64.85700 -22.42600 1.000 27.76000 ? 106 PHE B CD1 1 
ATOM   2455 C CD2 . PHE B 1 62  ? 53.57600 63.72100 -20.76200 1.000 27.89000 ? 106 PHE B CD2 1 
ATOM   2456 C CE1 . PHE B 1 62  ? 51.14500 64.60000 -21.71600 1.000 27.92000 ? 106 PHE B CE1 1 
ATOM   2457 C CE2 . PHE B 1 62  ? 52.42300 63.45900 -20.05100 1.000 27.17000 ? 106 PHE B CE2 1 
ATOM   2458 C CZ  . PHE B 1 62  ? 51.20600 63.90000 -20.52800 1.000 26.69000 ? 106 PHE B CZ  1 
ATOM   2459 N N   . THR B 1 63  ? 54.27400 67.58500 -21.01700 1.000 28.89000 ? 107 THR B N   1 
ATOM   2460 C CA  . THR B 1 63  ? 54.20600 68.27700 -19.72100 1.000 28.72000 ? 107 THR B CA  1 
ATOM   2461 C C   . THR B 1 63  ? 55.48700 69.04700 -19.41600 1.000 29.46000 ? 107 THR B C   1 
ATOM   2462 O O   . THR B 1 63  ? 55.83000 69.27900 -18.25400 1.000 31.23000 ? 107 THR B O   1 
ATOM   2463 C CB  . THR B 1 63  ? 53.87600 67.31200 -18.57500 1.000 27.48000 ? 107 THR B CB  1 
ATOM   2464 O OG1 . THR B 1 63  ? 54.85600 66.27100 -18.51000 1.000 29.06000 ? 107 THR B OG1 1 
ATOM   2465 C CG2 . THR B 1 63  ? 52.49800 66.70900 -18.76900 1.000 28.18000 ? 107 THR B CG2 1 
ATOM   2466 N N   . ALA B 1 64  ? 56.20300 69.44800 -20.45800 1.000 27.90000 ? 108 ALA B N   1 
ATOM   2467 C CA  . ALA B 1 64  ? 57.36900 70.30300 -20.33600 1.000 24.99000 ? 108 ALA B CA  1 
ATOM   2468 C C   . ALA B 1 64  ? 57.07200 71.64700 -20.98500 1.000 25.53000 ? 108 ALA B C   1 
ATOM   2469 O O   . ALA B 1 64  ? 56.07900 71.81800 -21.69600 1.000 30.09000 ? 108 ALA B O   1 
ATOM   2470 C CB  . ALA B 1 64  ? 58.60100 69.64700 -20.96900 1.000 25.78000 ? 108 ALA B CB  1 
ATOM   2471 N N   . SER B 1 65  ? 57.94500 72.61200 -20.71600 1.000 24.18000 ? 109 SER B N   1 
ATOM   2472 C CA  . SER B 1 65  ? 57.80800 73.96600 -21.22700 1.000 25.21000 ? 109 SER B CA  1 
ATOM   2473 C C   . SER B 1 65  ? 59.12000 74.37800 -21.88200 1.000 23.90000 ? 109 SER B C   1 
ATOM   2474 O O   . SER B 1 65  ? 60.09400 73.62000 -21.90300 1.000 24.04000 ? 109 SER B O   1 
ATOM   2475 C CB  . SER B 1 65  ? 57.42100 74.94100 -20.10800 1.000 28.35000 ? 109 SER B CB  1 
ATOM   2476 O OG  . SER B 1 65  ? 56.26500 74.49600 -19.41700 1.000 30.41000 ? 109 SER B OG  1 
ATOM   2477 N N   . GLN B 1 66  ? 59.14600 75.60200 -22.41300 1.000 25.79000 ? 110 GLN B N   1 
ATOM   2478 C CA  . GLN B 1 66  ? 60.34500 76.10100 -23.07700 1.000 22.84000 ? 110 GLN B CA  1 
ATOM   2479 C C   . GLN B 1 66  ? 61.52900 76.23500 -22.13000 1.000 26.65000 ? 110 GLN B C   1 
ATOM   2480 O O   . GLN B 1 66  ? 62.66800 76.33400 -22.59900 1.000 23.57000 ? 110 GLN B O   1 
ATOM   2481 C CB  . GLN B 1 66  ? 60.06500 77.45100 -23.73600 1.000 25.15000 ? 110 GLN B CB  1 
ATOM   2482 C CG  . GLN B 1 66  ? 59.56600 78.52600 -22.78800 1.000 27.56000 ? 110 GLN B CG  1 
ATOM   2483 C CD  . GLN B 1 66  ? 59.57800 79.89900 -23.42600 1.000 26.23000 ? 110 GLN B CD  1 
ATOM   2484 O OE1 . GLN B 1 66  ? 60.50200 80.24200 -24.16100 1.000 27.80000 ? 110 GLN B OE1 1 
ATOM   2485 N NE2 . GLN B 1 66  ? 58.54600 80.69000 -23.15500 1.000 30.08000 ? 110 GLN B NE2 1 
ATOM   2486 N N   . GLY B 1 67  ? 61.29300 76.24700 -20.81600 1.000 29.22000 ? 111 GLY B N   1 
ATOM   2487 C CA  . GLY B 1 67  ? 62.39800 76.34900 -19.87900 1.000 25.53000 ? 111 GLY B CA  1 
ATOM   2488 C C   . GLY B 1 67  ? 63.32800 75.15500 -19.92700 1.000 23.60000 ? 111 GLY B C   1 
ATOM   2489 O O   . GLY B 1 67  ? 64.52300 75.28100 -19.64500 1.000 24.83000 ? 111 GLY B O   1 
ATOM   2490 N N   . SER B 1 68  ? 62.80000 73.98300 -20.28200 1.000 26.53000 ? 112 SER B N   1 
ATOM   2491 C CA  . SER B 1 68  ? 63.63400 72.80000 -20.43800 1.000 25.73000 ? 112 SER B CA  1 
ATOM   2492 C C   . SER B 1 68  ? 64.52300 72.86800 -21.67200 1.000 26.48000 ? 112 SER B C   1 
ATOM   2493 O O   . SER B 1 68  ? 65.46700 72.07700 -21.77500 1.000 27.78000 ? 112 SER B O   1 
ATOM   2494 C CB  . SER B 1 68  ? 62.75800 71.54800 -20.49700 1.000 25.44000 ? 112 SER B CB  1 
ATOM   2495 O OG  . SER B 1 68  ? 61.88800 71.58700 -21.61500 1.000 26.96000 ? 112 SER B OG  1 
ATOM   2496 N N   . MET B 1 69  ? 64.25400 73.78900 -22.59900 1.000 29.41000 ? 113 MET B N   1 
ATOM   2497 C CA  . MET B 1 69  ? 65.02000 73.91500 -23.83400 1.000 27.49000 ? 113 MET B CA  1 
ATOM   2498 C C   . MET B 1 69  ? 65.69800 75.27200 -23.96900 1.000 27.43000 ? 113 MET B C   1 
ATOM   2499 O O   . MET B 1 69  ? 66.16300 75.61200 -25.06300 1.000 30.90000 ? 113 MET B O   1 
ATOM   2500 C CB  . MET B 1 69  ? 64.11400 73.67500 -25.04600 1.000 27.67000 ? 113 MET B CB  1 
ATOM   2501 C CG  . MET B 1 69  ? 63.23900 72.44300 -24.93400 1.000 23.40000 ? 113 MET B CG  1 
ATOM   2502 S SD  . MET B 1 69  ? 64.20900 70.93100 -24.89800 1.000 28.25000 ? 113 MET B SD  1 
ATOM   2503 C CE  . MET B 1 69  ? 64.85800 70.90400 -26.56600 1.000 26.08000 ? 113 MET B CE  1 
ATOM   2504 N N   . SER B 1 70  ? 65.77700 76.05000 -22.88800 1.000 27.60000 ? 114 SER B N   1 
ATOM   2505 C CA  . SER B 1 70  ? 66.20200 77.44200 -23.00600 1.000 28.06000 ? 114 SER B CA  1 
ATOM   2506 C C   . SER B 1 70  ? 67.69700 77.57200 -23.27400 1.000 25.54000 ? 114 SER B C   1 
ATOM   2507 O O   . SER B 1 70  ? 68.13100 78.57800 -23.84600 1.000 26.13000 ? 114 SER B O   1 
ATOM   2508 C CB  . SER B 1 70  ? 65.82300 78.21600 -21.74200 1.000 31.31000 ? 114 SER B CB  1 
ATOM   2509 O OG  . SER B 1 70  ? 66.46900 77.68400 -20.59800 1.000 29.95000 ? 114 SER B OG  1 
ATOM   2510 N N   . TRP B 1 71  ? 68.49900 76.58200 -22.87200 1.000 27.86000 ? 115 TRP B N   1 
ATOM   2511 C CA  . TRP B 1 71  ? 69.94300 76.71100 -23.03300 1.000 29.38000 ? 115 TRP B CA  1 
ATOM   2512 C C   . TRP B 1 71  ? 70.37800 76.60700 -24.48900 1.000 29.99000 ? 115 TRP B C   1 
ATOM   2513 O O   . TRP B 1 71  ? 71.50800 76.98800 -24.81300 1.000 31.64000 ? 115 TRP B O   1 
ATOM   2514 C CB  . TRP B 1 71  ? 70.67300 75.66300 -22.19100 1.000 27.32000 ? 115 TRP B CB  1 
ATOM   2515 C CG  . TRP B 1 71  ? 70.61100 74.26200 -22.72300 1.000 26.53000 ? 115 TRP B CG  1 
ATOM   2516 C CD1 . TRP B 1 71  ? 69.62700 73.34400 -22.50200 1.000 26.27000 ? 115 TRP B CD1 1 
ATOM   2517 C CD2 . TRP B 1 71  ? 71.59000 73.61100 -23.54400 1.000 24.81000 ? 115 TRP B CD2 1 
ATOM   2518 N NE1 . TRP B 1 71  ? 69.92700 72.16500 -23.14000 1.000 25.32000 ? 115 TRP B NE1 1 
ATOM   2519 C CE2 . TRP B 1 71  ? 71.12700 72.30400 -23.78700 1.000 24.17000 ? 115 TRP B CE2 1 
ATOM   2520 C CE3 . TRP B 1 71  ? 72.81000 74.00900 -24.10000 1.000 26.34000 ? 115 TRP B CE3 1 
ATOM   2521 C CZ2 . TRP B 1 71  ? 71.84100 71.39000 -24.56200 1.000 24.28000 ? 115 TRP B CZ2 1 
ATOM   2522 C CZ3 . TRP B 1 71  ? 73.51700 73.09900 -24.87000 1.000 26.86000 ? 115 TRP B CZ3 1 
ATOM   2523 C CH2 . TRP B 1 71  ? 73.02900 71.80600 -25.09400 1.000 23.26000 ? 115 TRP B CH2 1 
ATOM   2524 N N   . TYR B 1 72  ? 69.51000 76.10800 -25.37200 1.000 30.37000 ? 116 TYR B N   1 
ATOM   2525 C CA  . TYR B 1 72  ? 69.82300 76.09700 -26.79500 1.000 28.35000 ? 116 TYR B CA  1 
ATOM   2526 C C   . TYR B 1 72  ? 69.78200 77.49100 -27.40500 1.000 31.07000 ? 116 TYR B C   1 
ATOM   2527 O O   . TYR B 1 72  ? 70.34400 77.69600 -28.48600 1.000 32.21000 ? 116 TYR B O   1 
ATOM   2528 C CB  . TYR B 1 72  ? 68.85600 75.18000 -27.54500 1.000 26.54000 ? 116 TYR B CB  1 
ATOM   2529 C CG  . TYR B 1 72  ? 68.95200 73.72300 -27.15600 1.000 25.71000 ? 116 TYR B CG  1 
ATOM   2530 C CD1 . TYR B 1 72  ? 69.90300 72.89200 -27.73200 1.000 22.63000 ? 116 TYR B CD1 1 
ATOM   2531 C CD2 . TYR B 1 72  ? 68.08400 73.17700 -26.22000 1.000 24.31000 ? 116 TYR B CD2 1 
ATOM   2532 C CE1 . TYR B 1 72  ? 69.99100 71.55900 -27.38200 1.000 22.44000 ? 116 TYR B CE1 1 
ATOM   2533 C CE2 . TYR B 1 72  ? 68.16500 71.84800 -25.86400 1.000 24.82000 ? 116 TYR B CE2 1 
ATOM   2534 C CZ  . TYR B 1 72  ? 69.11800 71.04200 -26.44700 1.000 22.87000 ? 116 TYR B CZ  1 
ATOM   2535 O OH  . TYR B 1 72  ? 69.19800 69.71600 -26.08900 1.000 23.09000 ? 116 TYR B OH  1 
ATOM   2536 N N   . GLY B 1 73  ? 69.13400 78.44800 -26.74300 1.000 32.43000 ? 117 GLY B N   1 
ATOM   2537 C CA  . GLY B 1 73  ? 69.01300 79.79600 -27.26200 1.000 32.98000 ? 117 GLY B CA  1 
ATOM   2538 C C   . GLY B 1 73  ? 70.33800 80.49200 -27.49300 1.000 35.73000 ? 117 GLY B C   1 
ATOM   2539 O O   . GLY B 1 73  ? 70.81600 80.56300 -28.62800 1.000 37.37000 ? 117 GLY B O   1 
ATOM   2540 N N   . GLU B 1 74  ? 70.94600 81.00800 -26.42200 1.000 35.72000 ? 118 GLU B N   1 
ATOM   2541 C CA  . GLU B 1 74  ? 72.22500 81.69800 -26.54700 1.000 36.33000 ? 118 GLU B CA  1 
ATOM   2542 C C   . GLU B 1 74  ? 73.32500 80.79200 -27.08600 1.000 37.45000 ? 118 GLU B C   1 
ATOM   2543 O O   . GLU B 1 74  ? 74.31900 81.29500 -27.61900 1.000 40.88000 ? 118 GLU B O   1 
ATOM   2544 C CB  . GLU B 1 74  ? 72.64400 82.27000 -25.19300 1.000 39.67000 ? 118 GLU B CB  1 
ATOM   2545 C CG  . GLU B 1 74  ? 71.71500 83.34400 -24.65200 1.000 42.60000 ? 118 GLU B CG  1 
ATOM   2546 C CD  . GLU B 1 74  ? 72.14300 84.74100 -25.05400 1.000 45.17000 ? 118 GLU B CD  1 
ATOM   2547 O OE1 . GLU B 1 74  ? 73.09900 84.86600 -25.84800 1.000 45.13000 ? 118 GLU B OE1 1 
ATOM   2548 O OE2 . GLU B 1 74  ? 71.52800 85.71400 -24.56900 1.000 47.76000 ? 118 GLU B OE2 1 
ATOM   2549 N N   . ARG B 1 75  ? 73.17200 79.47300 -26.96200 1.000 35.41000 ? 119 ARG B N   1 
ATOM   2550 C CA  . ARG B 1 75  ? 74.20400 78.56000 -27.44200 1.000 34.89000 ? 119 ARG B CA  1 
ATOM   2551 C C   . ARG B 1 75  ? 74.20400 78.48600 -28.96500 1.000 37.90000 ? 119 ARG B C   1 
ATOM   2552 O O   . ARG B 1 75  ? 75.25000 78.64500 -29.60500 1.000 37.93000 ? 119 ARG B O   1 
ATOM   2553 C CB  . ARG B 1 75  ? 73.99500 77.17200 -26.83400 1.000 32.93000 ? 119 ARG B CB  1 
ATOM   2554 C CG  . ARG B 1 75  ? 75.15500 76.20600 -27.03300 1.000 31.73000 ? 119 ARG B CG  1 
ATOM   2555 C CD  . ARG B 1 75  ? 76.26800 76.46800 -26.03600 1.000 31.50000 ? 119 ARG B CD  1 
ATOM   2556 N NE  . ARG B 1 75  ? 77.42200 75.60000 -26.24000 1.000 32.75000 ? 119 ARG B NE  1 
ATOM   2557 C CZ  . ARG B 1 75  ? 77.73800 74.57400 -25.46200 1.000 32.23000 ? 119 ARG B CZ  1 
ATOM   2558 N NH1 . ARG B 1 75  ? 77.00700 74.25500 -24.40600 1.000 31.53000 ? 119 ARG B NH1 1 
ATOM   2559 N NH2 . ARG B 1 75  ? 78.81900 73.85300 -25.74600 1.000 31.70000 ? 119 ARG B NH2 1 
ATOM   2560 N N   . VAL B 1 76  ? 73.03700 78.25700 -29.56100 1.000 37.39000 ? 120 VAL B N   1 
ATOM   2561 C CA  . VAL B 1 76  ? 72.93800 78.07100 -31.00600 1.000 36.10000 ? 120 VAL B CA  1 
ATOM   2562 C C   . VAL B 1 76  ? 72.80600 79.40100 -31.73800 1.000 36.38000 ? 120 VAL B C   1 
ATOM   2563 O O   . VAL B 1 76  ? 73.40800 79.59100 -32.79800 1.000 39.08000 ? 120 VAL B O   1 
ATOM   2564 C CB  . VAL B 1 76  ? 71.76200 77.12600 -31.32600 1.000 34.76000 ? 120 VAL B CB  1 
ATOM   2565 C CG1 . VAL B 1 76  ? 71.43400 77.15400 -32.81000 1.000 36.74000 ? 120 VAL B CG1 1 
ATOM   2566 C CG2 . VAL B 1 76  ? 72.08900 75.71000 -30.88000 1.000 31.52000 ? 120 VAL B CG2 1 
ATOM   2567 N N   . ALA B 1 77  ? 72.03000 80.34000 -31.19100 1.000 35.23000 ? 121 ALA B N   1 
ATOM   2568 C CA  . ALA B 1 77  ? 71.82700 81.61500 -31.87300 1.000 36.04000 ? 121 ALA B CA  1 
ATOM   2569 C C   . ALA B 1 77  ? 73.12500 82.40000 -32.00900 1.000 35.94000 ? 121 ALA B C   1 
ATOM   2570 O O   . ALA B 1 77  ? 73.27900 83.18200 -32.95300 1.000 38.09000 ? 121 ALA B O   1 
ATOM   2571 C CB  . ALA B 1 77  ? 70.77700 82.45000 -31.13900 1.000 37.35000 ? 121 ALA B CB  1 
ATOM   2572 N N   . SER B 1 78  ? 74.07000 82.20300 -31.08800 1.000 36.01000 ? 122 SER B N   1 
ATOM   2573 C CA  . SER B 1 78  ? 75.35100 82.89700 -31.16400 1.000 38.51000 ? 122 SER B CA  1 
ATOM   2574 C C   . SER B 1 78  ? 76.25600 82.35100 -32.25900 1.000 40.22000 ? 122 SER B C   1 
ATOM   2575 O O   . SER B 1 78  ? 77.31200 82.93900 -32.51300 1.000 43.35000 ? 122 SER B O   1 
ATOM   2576 C CB  . SER B 1 78  ? 76.07400 82.82500 -29.81800 1.000 38.66000 ? 122 SER B CB  1 
ATOM   2577 O OG  . SER B 1 78  ? 76.37600 81.48600 -29.46900 1.000 37.78000 ? 122 SER B OG  1 
ATOM   2578 N N   . HIS B 1 79  ? 75.88000 81.24800 -32.90300 1.000 37.83000 ? 123 HIS B N   1 
ATOM   2579 C CA  . HIS B 1 79  ? 76.63300 80.70800 -34.02500 1.000 37.67000 ? 123 HIS B CA  1 
ATOM   2580 C C   . HIS B 1 79  ? 76.02700 81.08800 -35.36800 1.000 38.34000 ? 123 HIS B C   1 
ATOM   2581 O O   . HIS B 1 79  ? 76.47000 80.58100 -36.40300 1.000 40.07000 ? 123 HIS B O   1 
ATOM   2582 C CB  . HIS B 1 79  ? 76.74400 79.18800 -33.90300 1.000 37.63000 ? 123 HIS B CB  1 
ATOM   2583 C CG  . HIS B 1 79  ? 77.60600 78.73900 -32.76400 1.000 38.32000 ? 123 HIS B CG  1 
ATOM   2584 N ND1 . HIS B 1 79  ? 77.17400 78.74800 -31.45600 1.000 38.61000 ? 123 HIS B ND1 1 
ATOM   2585 C CD2 . HIS B 1 79  ? 78.88000 78.28200 -32.73700 1.000 38.94000 ? 123 HIS B CD2 1 
ATOM   2586 C CE1 . HIS B 1 79  ? 78.14200 78.30900 -30.67200 1.000 37.64000 ? 123 HIS B CE1 1 
ATOM   2587 N NE2 . HIS B 1 79  ? 79.18800 78.01900 -31.42400 1.000 39.58000 ? 123 HIS B NE2 1 
ATOM   2588 N N   . GLY B 1 80  ? 75.02600 81.96600 -35.37500 1.000 39.09000 ? 124 GLY B N   1 
ATOM   2589 C CA  . GLY B 1 80  ? 74.45000 82.45500 -36.61100 1.000 38.31000 ? 124 GLY B CA  1 
ATOM   2590 C C   . GLY B 1 80  ? 73.11900 81.82500 -36.96000 1.000 39.52000 ? 124 GLY B C   1 
ATOM   2591 O O   . GLY B 1 80  ? 72.92100 81.37700 -38.09400 1.000 40.14000 ? 124 GLY B O   1 
ATOM   2592 N N   . PHE B 1 81  ? 72.19300 81.79000 -36.00300 1.000 36.58000 ? 125 PHE B N   1 
ATOM   2593 C CA  . PHE B 1 81  ? 70.89100 81.17500 -36.21200 1.000 34.82000 ? 125 PHE B CA  1 
ATOM   2594 C C   . PHE B 1 81  ? 69.81800 81.94600 -35.45900 1.000 35.97000 ? 125 PHE B C   1 
ATOM   2595 O O   . PHE B 1 81  ? 70.07900 82.54800 -34.41500 1.000 39.03000 ? 125 PHE B O   1 
ATOM   2596 C CB  . PHE B 1 81  ? 70.87300 79.71000 -35.75400 1.000 38.20000 ? 125 PHE B CB  1 
ATOM   2597 C CG  . PHE B 1 81  ? 71.88000 78.84200 -36.44800 1.000 37.77000 ? 125 PHE B CG  1 
ATOM   2598 C CD1 . PHE B 1 81  ? 71.68800 78.45300 -37.76300 1.000 35.51000 ? 125 PHE B CD1 1 
ATOM   2599 C CD2 . PHE B 1 81  ? 73.01300 78.40500 -35.78300 1.000 37.03000 ? 125 PHE B CD2 1 
ATOM   2600 C CE1 . PHE B 1 81  ? 72.61200 77.65100 -38.40400 1.000 33.92000 ? 125 PHE B CE1 1 
ATOM   2601 C CE2 . PHE B 1 81  ? 73.94000 77.60200 -36.41800 1.000 38.08000 ? 125 PHE B CE2 1 
ATOM   2602 C CZ  . PHE B 1 81  ? 73.73800 77.22400 -37.73000 1.000 34.72000 ? 125 PHE B CZ  1 
ATOM   2603 N N   . ILE B 1 82  ? 68.60700 81.92000 -36.00500 1.000 34.82000 ? 126 ILE B N   1 
ATOM   2604 C CA  . ILE B 1 82  ? 67.42000 82.39400 -35.30200 1.000 35.92000 ? 126 ILE B CA  1 
ATOM   2605 C C   . ILE B 1 82  ? 66.80400 81.20100 -34.58400 1.000 37.34000 ? 126 ILE B C   1 
ATOM   2606 O O   . ILE B 1 82  ? 66.44300 80.20400 -35.21800 1.000 35.54000 ? 126 ILE B O   1 
ATOM   2607 C CB  . ILE B 1 82  ? 66.41700 83.04000 -36.26900 1.000 36.98000 ? 126 ILE B CB  1 
ATOM   2608 C CG1 . ILE B 1 82  ? 67.02400 84.28500 -36.91800 1.000 37.93000 ? 126 ILE B CG1 1 
ATOM   2609 C CG2 . ILE B 1 82  ? 65.12000 83.38400 -35.54800 1.000 36.86000 ? 126 ILE B CG2 1 
ATOM   2610 C CD1 . ILE B 1 82  ? 66.12800 84.92700 -37.95200 1.000 39.38000 ? 126 ILE B CD1 1 
ATOM   2611 N N   . VAL B 1 83  ? 66.69600 81.29000 -33.26000 1.000 37.91000 ? 127 VAL B N   1 
ATOM   2612 C CA  . VAL B 1 83  ? 66.21900 80.18800 -32.43300 1.000 33.21000 ? 127 VAL B CA  1 
ATOM   2613 C C   . VAL B 1 83  ? 64.92000 80.60900 -31.76400 1.000 29.21000 ? 127 VAL B C   1 
ATOM   2614 O O   . VAL B 1 83  ? 64.84000 81.69500 -31.17800 1.000 31.48000 ? 127 VAL B O   1 
ATOM   2615 C CB  . VAL B 1 83  ? 67.26500 79.77000 -31.38400 1.000 30.79000 ? 127 VAL B CB  1 
ATOM   2616 C CG1 . VAL B 1 83  ? 66.82100 78.50500 -30.67000 1.000 27.58000 ? 127 VAL B CG1 1 
ATOM   2617 C CG2 . VAL B 1 83  ? 68.62000 79.56800 -32.04200 1.000 31.83000 ? 127 VAL B CG2 1 
ATOM   2618 N N   . PHE B 1 84  ? 63.90800 79.74600 -31.84800 1.000 27.68000 ? 128 PHE B N   1 
ATOM   2619 C CA  . PHE B 1 84  ? 62.57700 80.00500 -31.29700 1.000 29.18000 ? 128 PHE B CA  1 
ATOM   2620 C C   . PHE B 1 84  ? 62.21600 78.83800 -30.38200 1.000 26.13000 ? 128 PHE B C   1 
ATOM   2621 O O   . PHE B 1 84  ? 61.64900 77.83900 -30.83300 1.000 25.53000 ? 128 PHE B O   1 
ATOM   2622 C CB  . PHE B 1 84  ? 61.55000 80.18700 -32.41400 1.000 26.68000 ? 128 PHE B CB  1 
ATOM   2623 C CG  . PHE B 1 84  ? 60.29800 80.90300 -31.98500 1.000 26.09000 ? 128 PHE B CG  1 
ATOM   2624 C CD1 . PHE B 1 84  ? 60.10300 81.27200 -30.66400 1.000 26.42000 ? 128 PHE B CD1 1 
ATOM   2625 C CD2 . PHE B 1 84  ? 59.31400 81.20700 -32.90900 1.000 26.74000 ? 128 PHE B CD2 1 
ATOM   2626 C CE1 . PHE B 1 84  ? 58.95400 81.92900 -30.27600 1.000 25.45000 ? 128 PHE B CE1 1 
ATOM   2627 C CE2 . PHE B 1 84  ? 58.16200 81.86400 -32.52700 1.000 28.62000 ? 128 PHE B CE2 1 
ATOM   2628 C CZ  . PHE B 1 84  ? 57.98200 82.22500 -31.20700 1.000 27.94000 ? 128 PHE B CZ  1 
ATOM   2629 N N   . THR B 1 85  ? 62.54900 78.96700 -29.10000 1.000 28.72000 ? 129 THR B N   1 
ATOM   2630 C CA  . THR B 1 85  ? 62.13400 77.99900 -28.09100 1.000 24.45000 ? 129 THR B CA  1 
ATOM   2631 C C   . THR B 1 85  ? 60.68500 78.29200 -27.72500 1.000 23.46000 ? 129 THR B C   1 
ATOM   2632 O O   . THR B 1 85  ? 60.39600 79.29500 -27.06400 1.000 26.04000 ? 129 THR B O   1 
ATOM   2633 C CB  . THR B 1 85  ? 63.03700 78.07700 -26.86400 1.000 24.78000 ? 129 THR B CB  1 
ATOM   2634 O OG1 . THR B 1 85  ? 62.81200 79.31900 -26.18600 1.000 29.36000 ? 129 THR B OG1 1 
ATOM   2635 C CG2 . THR B 1 85  ? 64.49600 77.99600 -27.27700 1.000 24.95000 ? 129 THR B CG2 1 
ATOM   2636 N N   . ILE B 1 86  ? 59.77400 77.42600 -28.15300 1.000 23.20000 ? 130 ILE B N   1 
ATOM   2637 C CA  . ILE B 1 86  ? 58.35400 77.71200 -28.08600 1.000 23.22000 ? 130 ILE B CA  1 
ATOM   2638 C C   . ILE B 1 86  ? 57.72300 76.95900 -26.92400 1.000 25.22000 ? 130 ILE B C   1 
ATOM   2639 O O   . ILE B 1 86  ? 58.27700 75.99500 -26.38700 1.000 24.77000 ? 130 ILE B O   1 
ATOM   2640 C CB  . ILE B 1 86  ? 57.64000 77.36200 -29.41200 1.000 24.06000 ? 130 ILE B CB  1 
ATOM   2641 C CG1 . ILE B 1 86  ? 57.45500 75.84700 -29.53500 1.000 24.37000 ? 130 ILE B CG1 1 
ATOM   2642 C CG2 . ILE B 1 86  ? 58.42600 77.89700 -30.59200 1.000 26.55000 ? 130 ILE B CG2 1 
ATOM   2643 C CD1 . ILE B 1 86  ? 56.61000 75.42400 -30.71900 1.000 26.79000 ? 130 ILE B CD1 1 
ATOM   2644 N N   . ASP B 1 87  ? 56.54300 77.41800 -26.52800 1.000 23.94000 ? 131 ASP B N   1 
ATOM   2645 C CA  . ASP B 1 87  ? 55.66400 76.69300 -25.62700 1.000 26.23000 ? 131 ASP B CA  1 
ATOM   2646 C C   . ASP B 1 87  ? 54.50300 76.11100 -26.41800 1.000 25.30000 ? 131 ASP B C   1 
ATOM   2647 O O   . ASP B 1 87  ? 54.06700 76.67800 -27.42200 1.000 26.43000 ? 131 ASP B O   1 
ATOM   2648 C CB  . ASP B 1 87  ? 55.12600 77.60400 -24.52300 1.000 28.92000 ? 131 ASP B CB  1 
ATOM   2649 C CG  . ASP B 1 87  ? 56.06100 77.69800 -23.34300 1.000 27.64000 ? 131 ASP B CG  1 
ATOM   2650 O OD1 . ASP B 1 87  ? 56.57400 76.64600 -22.90900 1.000 28.81000 ? 131 ASP B OD1 1 
ATOM   2651 O OD2 . ASP B 1 87  ? 56.28500 78.82300 -22.85100 1.000 32.54000 ? 131 ASP B OD2 1 
ATOM   2652 N N   . THR B 1 88  ? 54.00600 74.97100 -25.96100 1.000 26.41000 ? 132 THR B N   1 
ATOM   2653 C CA  . THR B 1 88  ? 52.86500 74.36600 -26.62100 1.000 25.62000 ? 132 THR B CA  1 
ATOM   2654 C C   . THR B 1 88  ? 51.56700 74.97900 -26.10500 1.000 27.16000 ? 132 THR B C   1 
ATOM   2655 O O   . THR B 1 88  ? 51.53300 75.63600 -25.06100 1.000 30.55000 ? 132 THR B O   1 
ATOM   2656 C CB  . THR B 1 88  ? 52.86100 72.85200 -26.41700 1.000 27.31000 ? 132 THR B CB  1 
ATOM   2657 O OG1 . THR B 1 88  ? 53.08000 72.55400 -25.03300 1.000 29.17000 ? 132 THR B OG1 1 
ATOM   2658 C CG2 . THR B 1 88  ? 53.95700 72.21200 -27.25100 1.000 25.17000 ? 132 THR B CG2 1 
ATOM   2659 N N   . ASN B 1 89  ? 50.49200 74.77500 -26.87200 1.000 25.51000 ? 133 ASN B N   1 
ATOM   2660 C CA  . ASN B 1 89  ? 49.18300 75.28000 -26.46800 1.000 27.48000 ? 133 ASN B CA  1 
ATOM   2661 C C   . ASN B 1 89  ? 48.78800 74.73200 -25.10300 1.000 27.63000 ? 133 ASN B C   1 
ATOM   2662 O O   . ASN B 1 89  ? 48.35700 75.48200 -24.21900 1.000 28.36000 ? 133 ASN B O   1 
ATOM   2663 C CB  . ASN B 1 89  ? 48.13200 74.92400 -27.52100 1.000 29.88000 ? 133 ASN B CB  1 
ATOM   2664 C CG  . ASN B 1 89  ? 48.28800 75.72600 -28.80100 1.000 27.90000 ? 133 ASN B CG  1 
ATOM   2665 O OD1 . ASN B 1 89  ? 48.68400 76.89100 -28.77400 1.000 28.52000 ? 133 ASN B OD1 1 
ATOM   2666 N ND2 . ASN B 1 89  ? 47.97000 75.10500 -29.93000 1.000 28.85000 ? 133 ASN B ND2 1 
ATOM   2667 N N   . THR B 1 90  ? 48.92100 73.42200 -24.91600 1.000 28.78000 ? 134 THR B N   1 
ATOM   2668 C CA  . THR B 1 90  ? 48.77400 72.79600 -23.61100 1.000 27.52000 ? 134 THR B CA  1 
ATOM   2669 C C   . THR B 1 90  ? 49.97300 71.89300 -23.36800 1.000 28.51000 ? 134 THR B C   1 
ATOM   2670 O O   . THR B 1 90  ? 50.59900 71.40200 -24.31100 1.000 28.29000 ? 134 THR B O   1 
ATOM   2671 C CB  . THR B 1 90  ? 47.48300 71.97100 -23.49500 1.000 27.45000 ? 134 THR B CB  1 
ATOM   2672 O OG1 . THR B 1 90  ? 47.63800 70.73600 -24.20500 1.000 31.26000 ? 134 THR B OG1 1 
ATOM   2673 C CG2 . THR B 1 90  ? 46.29600 72.73300 -24.06700 1.000 28.65000 ? 134 THR B CG2 1 
ATOM   2674 N N   . ARG B 1 91  ? 50.29100 71.67900 -22.09200 1.000 29.20000 ? 135 ARG B N   1 
ATOM   2675 C CA  . ARG B 1 91  ? 51.41000 70.81000 -21.75200 1.000 28.57000 ? 135 ARG B CA  1 
ATOM   2676 C C   . ARG B 1 91  ? 51.14300 69.35600 -22.12000 1.000 25.99000 ? 135 ARG B C   1 
ATOM   2677 O O   . ARG B 1 91  ? 52.08700 68.56300 -22.18700 1.000 25.94000 ? 135 ARG B O   1 
ATOM   2678 C CB  . ARG B 1 91  ? 51.72700 70.93000 -20.26100 1.000 29.91000 ? 135 ARG B CB  1 
ATOM   2679 C CG  . ARG B 1 91  ? 50.49600 70.85500 -19.37000 1.000 32.93000 ? 135 ARG B CG  1 
ATOM   2680 C CD  . ARG B 1 91  ? 50.82400 71.15500 -17.91200 1.000 34.74000 ? 135 ARG B CD  1 
ATOM   2681 N NE  . ARG B 1 91  ? 51.36000 69.99400 -17.21400 1.000 32.06000 ? 135 ARG B NE  1 
ATOM   2682 C CZ  . ARG B 1 91  ? 50.62700 69.12800 -16.52700 1.000 32.01000 ? 135 ARG B CZ  1 
ATOM   2683 N NH1 . ARG B 1 91  ? 49.31400 69.26300 -16.42400 1.000 31.69000 ? 135 ARG B NH1 1 
ATOM   2684 N NH2 . ARG B 1 91  ? 51.22400 68.10100 -15.93000 1.000 27.64000 ? 135 ARG B NH2 1 
ATOM   2685 N N   . LEU B 1 92  ? 49.88700 68.99600 -22.37300 1.000 26.60000 ? 136 LEU B N   1 
ATOM   2686 C CA  . LEU B 1 92  ? 49.49900 67.62600 -22.67700 1.000 27.34000 ? 136 LEU B CA  1 
ATOM   2687 C C   . LEU B 1 92  ? 49.47100 67.33100 -24.17200 1.000 24.58000 ? 136 LEU B C   1 
ATOM   2688 O O   . LEU B 1 92  ? 48.90300 66.31100 -24.57700 1.000 26.21000 ? 136 LEU B O   1 
ATOM   2689 C CB  . LEU B 1 92  ? 48.12500 67.32700 -22.07300 1.000 29.61000 ? 136 LEU B CB  1 
ATOM   2690 C CG  . LEU B 1 92  ? 47.93900 67.61300 -20.58300 1.000 26.91000 ? 136 LEU B CG  1 
ATOM   2691 C CD1 . LEU B 1 92  ? 46.51600 67.29400 -20.17000 1.000 27.15000 ? 136 LEU B CD1 1 
ATOM   2692 C CD2 . LEU B 1 92  ? 48.93000 66.81800 -19.75300 1.000 28.08000 ? 136 LEU B CD2 1 
ATOM   2693 N N   . ASP B 1 93  ? 50.07000 68.18700 -24.99500 1.000 26.66000 ? 137 ASP B N   1 
ATOM   2694 C CA  . ASP B 1 93  ? 49.97100 68.02700 -26.44000 1.000 24.59000 ? 137 ASP B CA  1 
ATOM   2695 C C   . ASP B 1 93  ? 50.75800 66.81500 -26.92300 1.000 23.88000 ? 137 ASP B C   1 
ATOM   2696 O O   . ASP B 1 93  ? 51.89200 66.57400 -26.49800 1.000 25.61000 ? 137 ASP B O   1 
ATOM   2697 C CB  . ASP B 1 93  ? 50.46200 69.28600 -27.14900 1.000 22.28000 ? 137 ASP B CB  1 
ATOM   2698 C CG  . ASP B 1 93  ? 49.49500 70.43900 -27.01000 1.000 25.42000 ? 137 ASP B CG  1 
ATOM   2699 O OD1 . ASP B 1 93  ? 48.29200 70.18000 -26.80400 1.000 27.92000 ? 137 ASP B OD1 1 
ATOM   2700 O OD2 . ASP B 1 93  ? 49.93600 71.60200 -27.10600 1.000 28.00000 ? 137 ASP B OD2 1 
ATOM   2701 N N   . ALA B 1 94  ? 50.14200 66.05900 -27.82500 1.000 24.20000 ? 138 ALA B N   1 
ATOM   2702 C CA  . ALA B 1 94  ? 50.72900 64.86300 -28.40500 1.000 21.98000 ? 138 ALA B CA  1 
ATOM   2703 C C   . ALA B 1 94  ? 51.76600 65.25000 -29.45600 1.000 23.22000 ? 138 ALA B C   1 
ATOM   2704 O O   . ALA B 1 94  ? 51.83800 66.40800 -29.87100 1.000 22.73000 ? 138 ALA B O   1 
ATOM   2705 C CB  . ALA B 1 94  ? 49.61800 63.99900 -28.99700 1.000 22.89000 ? 138 ALA B CB  1 
ATOM   2706 N N   . PRO B 1 95  ? 52.60900 64.30300 -29.89600 1.000 23.13000 ? 139 PRO B N   1 
ATOM   2707 C CA  . PRO B 1 95  ? 53.62200 64.66000 -30.90700 1.000 23.01000 ? 139 PRO B CA  1 
ATOM   2708 C C   . PRO B 1 95  ? 53.03600 65.23300 -32.18500 1.000 22.80000 ? 139 PRO B C   1 
ATOM   2709 O O   . PRO B 1 95  ? 53.62600 66.14900 -32.77200 1.000 25.51000 ? 139 PRO B O   1 
ATOM   2710 C CB  . PRO B 1 95  ? 54.34600 63.33100 -31.16200 1.000 21.34000 ? 139 PRO B CB  1 
ATOM   2711 C CG  . PRO B 1 95  ? 54.17600 62.56900 -29.91100 1.000 22.26000 ? 139 PRO B CG  1 
ATOM   2712 C CD  . PRO B 1 95  ? 52.81900 62.93800 -29.37700 1.000 23.98000 ? 139 PRO B CD  1 
ATOM   2713 N N   . GLY B 1 96  ? 51.89300 64.71600 -32.63800 1.000 22.79000 ? 140 GLY B N   1 
ATOM   2714 C CA  . GLY B 1 96  ? 51.25700 65.28200 -33.81600 1.000 25.62000 ? 140 GLY B CA  1 
ATOM   2715 C C   . GLY B 1 96  ? 50.88800 66.74000 -33.63300 1.000 25.70000 ? 140 GLY B C   1 
ATOM   2716 O O   . GLY B 1 96  ? 51.10800 67.56200 -34.52600 1.000 25.69000 ? 140 GLY B O   1 
ATOM   2717 N N   . GLN B 1 97  ? 50.33000 67.08600 -32.47000 1.000 24.94000 ? 141 GLN B N   1 
ATOM   2718 C CA  . GLN B 1 97  ? 50.01300 68.48500 -32.21100 1.000 23.78000 ? 141 GLN B CA  1 
ATOM   2719 C C   . GLN B 1 97  ? 51.28100 69.31800 -32.10300 1.000 22.23000 ? 141 GLN B C   1 
ATOM   2720 O O   . GLN B 1 97  ? 51.30700 70.47900 -32.52700 1.000 25.14000 ? 141 GLN B O   1 
ATOM   2721 C CB  . GLN B 1 97  ? 49.17600 68.60500 -30.93400 1.000 21.53000 ? 141 GLN B CB  1 
ATOM   2722 C CG  . GLN B 1 97  ? 47.80500 67.96900 -31.04000 1.000 23.75000 ? 141 GLN B CG  1 
ATOM   2723 C CD  . GLN B 1 97  ? 47.10700 67.86800 -29.69900 1.000 29.55000 ? 141 GLN B CD  1 
ATOM   2724 O OE1 . GLN B 1 97  ? 47.65100 67.31100 -28.74600 1.000 29.30000 ? 141 GLN B OE1 1 
ATOM   2725 N NE2 . GLN B 1 97  ? 45.90000 68.41500 -29.61600 1.000 29.39000 ? 141 GLN B NE2 1 
ATOM   2726 N N   . ARG B 1 98  ? 52.35100 68.73500 -31.55800 1.000 22.15000 ? 142 ARG B N   1 
ATOM   2727 C CA  . ARG B 1 98  ? 53.60300 69.46800 -31.41700 1.000 22.75000 ? 142 ARG B CA  1 
ATOM   2728 C C   . ARG B 1 98  ? 54.26900 69.71500 -32.76600 1.000 24.66000 ? 142 ARG B C   1 
ATOM   2729 O O   . ARG B 1 98  ? 54.99800 70.70100 -32.92400 1.000 23.82000 ? 142 ARG B O   1 
ATOM   2730 C CB  . ARG B 1 98  ? 54.53900 68.71400 -30.47400 1.000 23.00000 ? 142 ARG B CB  1 
ATOM   2731 C CG  . ARG B 1 98  ? 54.02300 68.67200 -29.05100 1.000 23.91000 ? 142 ARG B CG  1 
ATOM   2732 C CD  . ARG B 1 98  ? 54.90000 67.83100 -28.14900 1.000 24.44000 ? 142 ARG B CD  1 
ATOM   2733 N NE  . ARG B 1 98  ? 54.32600 67.75600 -26.81300 1.000 23.29000 ? 142 ARG B NE  1 
ATOM   2734 C CZ  . ARG B 1 98  ? 54.58500 68.61700 -25.83900 1.000 24.97000 ? 142 ARG B CZ  1 
ATOM   2735 N NH1 . ARG B 1 98  ? 55.47800 69.58100 -25.98800 1.000 23.73000 ? 142 ARG B NH1 1 
ATOM   2736 N NH2 . ARG B 1 98  ? 53.92700 68.51000 -24.68800 1.000 27.77000 ? 142 ARG B NH2 1 
ATOM   2737 N N   . GLY B 1 99  ? 54.02900 68.84200 -33.74500 1.000 27.02000 ? 143 GLY B N   1 
ATOM   2738 C CA  . GLY B 1 99  ? 54.50100 69.11500 -35.09100 1.000 23.20000 ? 143 GLY B CA  1 
ATOM   2739 C C   . GLY B 1 99  ? 53.75700 70.26600 -35.74100 1.000 25.40000 ? 143 GLY B C   1 
ATOM   2740 O O   . GLY B 1 99  ? 54.36400 71.11400 -36.40000 1.000 26.69000 ? 143 GLY B O   1 
ATOM   2741 N N   . ARG B 1 100 ? 52.43400 70.31400 -35.56200 1.000 25.47000 ? 144 ARG B N   1 
ATOM   2742 C CA  . ARG B 1 100 ? 51.65400 71.42200 -36.10400 1.000 26.21000 ? 144 ARG B CA  1 
ATOM   2743 C C   . ARG B 1 100 ? 52.09300 72.75100 -35.50600 1.000 26.68000 ? 144 ARG B C   1 
ATOM   2744 O O   . ARG B 1 100 ? 52.15900 73.76500 -36.21000 1.000 26.87000 ? 144 ARG B O   1 
ATOM   2745 C CB  . ARG B 1 100 ? 50.16400 71.19200 -35.85100 1.000 26.55000 ? 144 ARG B CB  1 
ATOM   2746 C CG  . ARG B 1 100 ? 49.56200 70.08000 -36.68200 1.000 30.84000 ? 144 ARG B CG  1 
ATOM   2747 C CD  . ARG B 1 100 ? 49.58100 70.44500 -38.15300 1.000 35.29000 ? 144 ARG B CD  1 
ATOM   2748 N NE  . ARG B 1 100 ? 49.12800 69.34700 -38.99700 1.000 40.57000 ? 144 ARG B NE  1 
ATOM   2749 C CZ  . ARG B 1 100 ? 49.19700 69.34900 -40.32100 1.000 38.66000 ? 144 ARG B CZ  1 
ATOM   2750 N NH1 . ARG B 1 100 ? 49.70200 70.37700 -40.98400 1.000 34.37000 ? 144 ARG B NH1 1 
ATOM   2751 N NH2 . ARG B 1 100 ? 48.75200 68.29300 -40.99600 1.000 37.62000 ? 144 ARG B NH2 1 
ATOM   2752 N N   . GLN B 1 101 ? 52.40100 72.76600 -34.20800 1.000 26.88000 ? 145 GLN B N   1 
ATOM   2753 C CA  . GLN B 1 101 ? 52.78800 74.00700 -33.54900 1.000 26.53000 ? 145 GLN B CA  1 
ATOM   2754 C C   . GLN B 1 101 ? 54.23100 74.39400 -33.83600 1.000 23.31000 ? 145 GLN B C   1 
ATOM   2755 O O   . GLN B 1 101 ? 54.58300 75.57100 -33.69700 1.000 22.66000 ? 145 GLN B O   1 
ATOM   2756 C CB  . GLN B 1 101 ? 52.55400 73.88800 -32.04400 1.000 25.68000 ? 145 GLN B CB  1 
ATOM   2757 C CG  . GLN B 1 101 ? 51.11400 73.54800 -31.69600 1.000 25.67000 ? 145 GLN B CG  1 
ATOM   2758 C CD  . GLN B 1 101 ? 50.91500 73.26000 -30.22700 1.000 25.81000 ? 145 GLN B CD  1 
ATOM   2759 O OE1 . GLN B 1 101 ? 51.56000 73.86200 -29.37600 1.000 28.02000 ? 145 GLN B OE1 1 
ATOM   2760 N NE2 . GLN B 1 101 ? 50.02000 72.32800 -29.92200 1.000 25.32000 ? 145 GLN B NE2 1 
ATOM   2761 N N   . LEU B 1 102 ? 55.06900 73.43300 -34.22900 1.000 24.36000 ? 146 LEU B N   1 
ATOM   2762 C CA  . LEU B 1 102 ? 56.38800 73.77400 -34.74900 1.000 24.51000 ? 146 LEU B CA  1 
ATOM   2763 C C   . LEU B 1 102 ? 56.27400 74.52900 -36.06800 1.000 25.96000 ? 146 LEU B C   1 
ATOM   2764 O O   . LEU B 1 102 ? 57.04000 75.46600 -36.32200 1.000 25.78000 ? 146 LEU B O   1 
ATOM   2765 C CB  . LEU B 1 102 ? 57.22800 72.50900 -34.92300 1.000 23.63000 ? 146 LEU B CB  1 
ATOM   2766 C CG  . LEU B 1 102 ? 57.91600 71.95000 -33.67600 1.000 23.86000 ? 146 LEU B CG  1 
ATOM   2767 C CD1 . LEU B 1 102 ? 58.37700 70.52100 -33.90700 1.000 23.36000 ? 146 LEU B CD1 1 
ATOM   2768 C CD2 . LEU B 1 102 ? 59.09200 72.82900 -33.29400 1.000 20.98000 ? 146 LEU B CD2 1 
ATOM   2769 N N   . LEU B 1 103 ? 55.32000 74.14000 -36.91800 1.000 26.08000 ? 147 LEU B N   1 
ATOM   2770 C CA  . LEU B 1 103 ? 55.10600 74.86500 -38.16500 1.000 26.41000 ? 147 LEU B CA  1 
ATOM   2771 C C   . LEU B 1 103 ? 54.51300 76.24300 -37.90500 1.000 26.51000 ? 147 LEU B C   1 
ATOM   2772 O O   . LEU B 1 103 ? 54.85900 77.21200 -38.58900 1.000 30.72000 ? 147 LEU B O   1 
ATOM   2773 C CB  . LEU B 1 103 ? 54.19400 74.06500 -39.09400 1.000 28.25000 ? 147 LEU B CB  1 
ATOM   2774 C CG  . LEU B 1 103 ? 54.59900 72.62800 -39.42100 1.000 25.69000 ? 147 LEU B CG  1 
ATOM   2775 C CD1 . LEU B 1 103 ? 53.61700 72.02100 -40.40400 1.000 26.92000 ? 147 LEU B CD1 1 
ATOM   2776 C CD2 . LEU B 1 103 ? 56.01300 72.58100 -39.96900 1.000 24.86000 ? 147 LEU B CD2 1 
ATOM   2777 N N   . ALA B 1 104 ? 53.61400 76.34700 -36.92300 1.000 28.92000 ? 148 ALA B N   1 
ATOM   2778 C CA  . ALA B 1 104 ? 52.99600 77.63300 -36.61800 1.000 28.11000 ? 148 ALA B CA  1 
ATOM   2779 C C   . ALA B 1 104 ? 54.02400 78.63100 -36.10300 1.000 27.41000 ? 148 ALA B C   1 
ATOM   2780 O O   . ALA B 1 104 ? 53.93000 79.83100 -36.39000 1.000 31.68000 ? 148 ALA B O   1 
ATOM   2781 C CB  . ALA B 1 104 ? 51.86900 77.44700 -35.60300 1.000 27.21000 ? 148 ALA B CB  1 
ATOM   2782 N N   . ALA B 1 105 ? 55.01100 78.15700 -35.34200 1.000 26.78000 ? 149 ALA B N   1 
ATOM   2783 C CA  . ALA B 1 105 ? 56.06700 79.04400 -34.86700 1.000 28.35000 ? 149 ALA B CA  1 
ATOM   2784 C C   . ALA B 1 105 ? 56.92800 79.53900 -36.02100 1.000 32.03000 ? 149 ALA B C   1 
ATOM   2785 O O   . ALA B 1 105 ? 57.35700 80.69800 -36.03100 1.000 32.84000 ? 149 ALA B O   1 
ATOM   2786 C CB  . ALA B 1 105 ? 56.92400 78.32800 -33.82500 1.000 27.34000 ? 149 ALA B CB  1 
ATOM   2787 N N   . LEU B 1 106 ? 57.19000 78.67200 -37.00200 1.000 31.02000 ? 150 LEU B N   1 
ATOM   2788 C CA  . LEU B 1 106 ? 57.92900 79.09500 -38.18700 1.000 29.75000 ? 150 LEU B CA  1 
ATOM   2789 C C   . LEU B 1 106 ? 57.09300 80.03000 -39.05000 1.000 31.26000 ? 150 LEU B C   1 
ATOM   2790 O O   . LEU B 1 106 ? 57.60800 81.02500 -39.57400 1.000 33.69000 ? 150 LEU B O   1 
ATOM   2791 C CB  . LEU B 1 106 ? 58.37500 77.87200 -38.98900 1.000 28.79000 ? 150 LEU B CB  1 
ATOM   2792 C CG  . LEU B 1 106 ? 59.38700 76.94600 -38.31000 1.000 28.15000 ? 150 LEU B CG  1 
ATOM   2793 C CD1 . LEU B 1 106 ? 59.59400 75.68800 -39.13400 1.000 29.51000 ? 150 LEU B CD1 1 
ATOM   2794 C CD2 . LEU B 1 106 ? 60.71000 77.66200 -38.08400 1.000 26.54000 ? 150 LEU B CD2 1 
ATOM   2795 N N   . ASP B 1 107 ? 55.80000 79.73100 -39.20600 1.000 33.84000 ? 151 ASP B N   1 
ATOM   2796 C CA  . ASP B 1 107 ? 54.91900 80.62600 -39.94900 1.000 33.88000 ? 151 ASP B CA  1 
ATOM   2797 C C   . ASP B 1 107 ? 54.81400 81.98900 -39.27900 1.000 36.16000 ? 151 ASP B C   1 
ATOM   2798 O O   . ASP B 1 107 ? 54.65800 83.00500 -39.96400 1.000 38.18000 ? 151 ASP B O   1 
ATOM   2799 C CB  . ASP B 1 107 ? 53.53300 79.99800 -40.10100 1.000 32.19000 ? 151 ASP B CB  1 
ATOM   2800 C CG  . ASP B 1 107 ? 53.54900 78.76000 -40.97300 1.000 32.27000 ? 151 ASP B CG  1 
ATOM   2801 O OD1 . ASP B 1 107 ? 54.48300 78.62400 -41.79100 1.000 32.61000 ? 151 ASP B OD1 1 
ATOM   2802 O OD2 . ASP B 1 107 ? 52.62900 77.92400 -40.84500 1.000 28.61000 ? 151 ASP B OD2 1 
ATOM   2803 N N   . TYR B 1 108 ? 54.89600 82.03300 -37.94700 1.000 36.35000 ? 152 TYR B N   1 
ATOM   2804 C CA  . TYR B 1 108 ? 54.90600 83.31500 -37.25000 1.000 36.72000 ? 152 TYR B CA  1 
ATOM   2805 C C   . TYR B 1 108 ? 56.11800 84.14500 -37.65700 1.000 37.04000 ? 152 TYR B C   1 
ATOM   2806 O O   . TYR B 1 108 ? 55.99600 85.33700 -37.95800 1.000 39.87000 ? 152 TYR B O   1 
ATOM   2807 C CB  . TYR B 1 108 ? 54.88800 83.09200 -35.73600 1.000 34.48000 ? 152 TYR B CB  1 
ATOM   2808 C CG  . TYR B 1 108 ? 55.16900 84.34600 -34.93400 1.000 33.86000 ? 152 TYR B CG  1 
ATOM   2809 C CD1 . TYR B 1 108 ? 54.14100 85.20700 -34.57200 1.000 33.10000 ? 152 TYR B CD1 1 
ATOM   2810 C CD2 . TYR B 1 108 ? 56.46200 84.66800 -34.53900 1.000 33.65000 ? 152 TYR B CD2 1 
ATOM   2811 C CE1 . TYR B 1 108 ? 54.39400 86.35200 -33.84300 1.000 34.13000 ? 152 TYR B CE1 1 
ATOM   2812 C CE2 . TYR B 1 108 ? 56.72400 85.81100 -33.81600 1.000 33.99000 ? 152 TYR B CE2 1 
ATOM   2813 C CZ  . TYR B 1 108 ? 55.68700 86.64900 -33.46800 1.000 36.22000 ? 152 TYR B CZ  1 
ATOM   2814 O OH  . TYR B 1 108 ? 55.94500 87.78900 -32.74100 1.000 42.39000 ? 152 TYR B OH  1 
ATOM   2815 N N   . LEU B 1 109 ? 57.30100 83.52600 -37.66100 1.000 34.74000 ? 153 LEU B N   1 
ATOM   2816 C CA  . LEU B 1 109 ? 58.52100 84.24600 -38.01400 1.000 35.48000 ? 153 LEU B CA  1 
ATOM   2817 C C   . LEU B 1 109 ? 58.45500 84.78500 -39.43700 1.000 38.96000 ? 153 LEU B C   1 
ATOM   2818 O O   . LEU B 1 109 ? 58.94100 85.88700 -39.71700 1.000 41.02000 ? 153 LEU B O   1 
ATOM   2819 C CB  . LEU B 1 109 ? 59.73300 83.32900 -37.85100 1.000 34.42000 ? 153 LEU B CB  1 
ATOM   2820 C CG  . LEU B 1 109 ? 60.00900 82.75800 -36.45900 1.000 33.48000 ? 153 LEU B CG  1 
ATOM   2821 C CD1 . LEU B 1 109 ? 60.69500 81.40700 -36.56900 1.000 30.69000 ? 153 LEU B CD1 1 
ATOM   2822 C CD2 . LEU B 1 109 ? 60.86100 83.71900 -35.65000 1.000 33.88000 ? 153 LEU B CD2 1 
ATOM   2823 N N   . VAL B 1 110 ? 57.85100 84.02500 -40.34900 1.000 37.97000 ? 154 VAL B N   1 
ATOM   2824 C CA  . VAL B 1 110 ? 57.83500 84.42800 -41.74900 1.000 40.56000 ? 154 VAL B CA  1 
ATOM   2825 C C   . VAL B 1 110 ? 56.70000 85.40700 -42.03200 1.000 39.98000 ? 154 VAL B C   1 
ATOM   2826 O O   . VAL B 1 110 ? 56.82600 86.27000 -42.90700 1.000 41.22000 ? 154 VAL B O   1 
ATOM   2827 C CB  . VAL B 1 110 ? 57.75100 83.18100 -42.64900 1.000 38.11000 ? 154 VAL B CB  1 
ATOM   2828 C CG1 . VAL B 1 110 ? 57.79000 83.56800 -44.12100 1.000 42.60000 ? 154 VAL B CG1 1 
ATOM   2829 C CG2 . VAL B 1 110 ? 58.88500 82.22200 -42.32100 1.000 35.03000 ? 154 VAL B CG2 1 
ATOM   2830 N N   . GLU B 1 111 ? 55.59600 85.32300 -41.29500 1.000 40.44000 ? 155 GLU B N   1 
ATOM   2831 C CA  . GLU B 1 111 ? 54.39500 86.08300 -41.62100 1.000 40.07000 ? 155 GLU B CA  1 
ATOM   2832 C C   . GLU B 1 111 ? 54.09100 87.21300 -40.65100 1.000 41.83000 ? 155 GLU B C   1 
ATOM   2833 O O   . GLU B 1 111 ? 53.62800 88.27200 -41.08000 1.000 42.25000 ? 155 GLU B O   1 
ATOM   2834 C CB  . GLU B 1 111 ? 53.18500 85.14500 -41.68700 1.000 40.97000 ? 155 GLU B CB  1 
ATOM   2835 C CG  . GLU B 1 111 ? 53.30100 84.05900 -42.74600 1.000 41.42000 ? 155 GLU B CG  1 
ATOM   2836 C CD  . GLU B 1 111 ? 52.23000 82.99500 -42.61100 1.000 42.22000 ? 155 GLU B CD  1 
ATOM   2837 O OE1 . GLU B 1 111 ? 51.71100 82.82100 -41.48900 1.000 47.59000 ? 155 GLU B OE1 1 
ATOM   2838 O OE2 . GLU B 1 111 ? 51.90300 82.33600 -43.62100 1.000 43.90000 ? 155 GLU B OE2 1 
ATOM   2839 N N   . ARG B 1 112 ? 54.33300 87.02900 -39.35200 1.000 44.22000 ? 156 ARG B N   1 
ATOM   2840 C CA  . ARG B 1 112 ? 53.81400 87.95900 -38.35400 1.000 43.26000 ? 156 ARG B CA  1 
ATOM   2841 C C   . ARG B 1 112 ? 54.84300 88.24800 -37.26700 1.000 41.95000 ? 156 ARG B C   1 
ATOM   2842 O O   . ARG B 1 112 ? 54.49300 88.42400 -36.09500 1.000 46.86000 ? 156 ARG B O   1 
ATOM   2843 C CB  . ARG B 1 112 ? 52.52500 87.41800 -37.73000 1.000 39.15000 ? 156 ARG B CB  1 
ATOM   2844 C CG  . ARG B 1 112 ? 51.31900 87.46900 -38.65700 1.000 39.31000 ? 156 ARG B CG  1 
ATOM   2845 C CD  . ARG B 1 112 ? 50.17900 86.57000 -38.18500 1.000 42.33000 ? 156 ARG B CD  1 
ATOM   2846 N NE  . ARG B 1 112 ? 50.13700 85.30700 -38.91400 1.000 43.50000 ? 156 ARG B NE  1 
ATOM   2847 C CZ  . ARG B 1 112 ? 50.52400 84.13700 -38.42500 1.000 43.31000 ? 156 ARG B CZ  1 
ATOM   2848 N NH1 . ARG B 1 112 ? 50.97500 84.01900 -37.18700 1.000 42.86000 ? 156 ARG B NH1 1 
ATOM   2849 N NH2 . ARG B 1 112 ? 50.45000 83.05500 -39.19600 1.000 41.91000 ? 156 ARG B NH2 1 
ATOM   2850 N N   . SER B 1 113 ? 56.12000 88.33000 -37.63600 1.000 41.38000 ? 157 SER B N   1 
ATOM   2851 C CA  . SER B 1 113 ? 57.16600 88.54400 -36.65200 1.000 42.54000 ? 157 SER B CA  1 
ATOM   2852 C C   . SER B 1 113 ? 57.49700 90.03100 -36.54400 1.000 48.18000 ? 157 SER B C   1 
ATOM   2853 O O   . SER B 1 113 ? 56.97400 90.87100 -37.27900 1.000 50.82000 ? 157 SER B O   1 
ATOM   2854 C CB  . SER B 1 113 ? 58.40200 87.72200 -37.00500 1.000 42.64000 ? 157 SER B CB  1 
ATOM   2855 O OG  . SER B 1 113 ? 58.91700 88.09500 -38.27000 1.000 44.74000 ? 157 SER B OG  1 
ATOM   2856 N N   . ASP B 1 114 ? 58.37100 90.35600 -35.59500 1.000 51.74000 ? 158 ASP B N   1 
ATOM   2857 C CA  . ASP B 1 114 ? 58.84900 91.71400 -35.40500 1.000 54.47000 ? 158 ASP B CA  1 
ATOM   2858 C C   . ASP B 1 114 ? 59.75000 92.12200 -36.57000 1.000 54.76000 ? 158 ASP B C   1 
ATOM   2859 O O   . ASP B 1 114 ? 60.18300 91.29500 -37.37800 1.000 53.59000 ? 158 ASP B O   1 
ATOM   2860 C CB  . ASP B 1 114 ? 59.60500 91.82600 -34.07700 1.000 53.48000 ? 158 ASP B CB  1 
ATOM   2861 C CG  . ASP B 1 114 ? 59.87200 93.26500 -33.66600 1.000 57.92000 ? 158 ASP B CG  1 
ATOM   2862 O OD1 . ASP B 1 114 ? 59.29300 94.18100 -34.28500 1.000 59.50000 ? 158 ASP B OD1 1 
ATOM   2863 O OD2 . ASP B 1 114 ? 60.66700 93.48300 -32.72600 1.000 60.51000 ? 158 ASP B OD2 1 
ATOM   2864 N N   . ARG B 1 115 ? 60.03200 93.42400 -36.65500 1.000 57.60000 ? 159 ARG B N   1 
ATOM   2865 C CA  . ARG B 1 115 ? 60.93600 93.90500 -37.69400 1.000 56.43000 ? 159 ARG B CA  1 
ATOM   2866 C C   . ARG B 1 115 ? 62.36400 93.44300 -37.44000 1.000 55.84000 ? 159 ARG B C   1 
ATOM   2867 O O   . ARG B 1 115 ? 63.07400 93.06800 -38.38000 1.000 56.34000 ? 159 ARG B O   1 
ATOM   2868 C CB  . ARG B 1 115 ? 60.87200 95.42900 -37.79600 1.000 60.08000 ? 159 ARG B CB  1 
ATOM   2869 C CG  . ARG B 1 115 ? 61.17500 96.16700 -36.50200 1.000 63.88000 ? 159 ARG B CG  1 
ATOM   2870 C CD  . ARG B 1 115 ? 61.75800 97.54200 -36.77700 1.000 64.59000 ? 159 ARG B CD  1 
ATOM   2871 N NE  . ARG B 1 115 ? 63.08900 97.46500 -37.37000 1.000 66.03000 ? 159 ARG B NE  1 
ATOM   2872 C CZ  . ARG B 1 115 ? 64.22200 97.49600 -36.68100 1.000 63.89000 ? 159 ARG B CZ  1 
ATOM   2873 N NH1 . ARG B 1 115 ? 64.22700 97.61400 -35.36400 1.000 60.09000 ? 159 ARG B NH1 1 
ATOM   2874 N NH2 . ARG B 1 115 ? 65.37900 97.40800 -37.33100 1.000 65.08000 ? 159 ARG B NH2 1 
ATOM   2875 N N   . LYS B 1 116 ? 62.80300 93.45400 -36.17800 1.000 55.62000 ? 160 LYS B N   1 
ATOM   2876 C CA  . LYS B 1 116 ? 64.15100 92.99100 -35.85600 1.000 55.21000 ? 160 LYS B CA  1 
ATOM   2877 C C   . LYS B 1 116 ? 64.34300 91.51800 -36.17900 1.000 52.85000 ? 160 LYS B C   1 
ATOM   2878 O O   . LYS B 1 116 ? 65.48500 91.07300 -36.34200 1.000 49.10000 ? 160 LYS B O   1 
ATOM   2879 C CB  . LYS B 1 116 ? 64.46000 93.25000 -34.37900 1.000 55.08000 ? 160 LYS B CB  1 
ATOM   2880 C CG  . LYS B 1 116 ? 64.48800 94.71900 -33.99600 1.000 57.26000 ? 160 LYS B CG  1 
ATOM   2881 C CD  . LYS B 1 116 ? 65.10000 94.93000 -32.61900 1.000 59.75000 ? 160 LYS B CD  1 
ATOM   2882 C CE  . LYS B 1 116 ? 64.18900 94.42400 -31.51100 1.000 57.47000 ? 160 LYS B CE  1 
ATOM   2883 N NZ  . LYS B 1 116 ? 62.95600 95.24800 -31.37400 1.000 57.06000 ? 160 LYS B NZ  1 
ATOM   2884 N N   . VAL B 1 117 ? 63.25600 90.75900 -36.27900 1.000 54.32000 ? 161 VAL B N   1 
ATOM   2885 C CA  . VAL B 1 117 ? 63.31600 89.34800 -36.64000 1.000 53.18000 ? 161 VAL B CA  1 
ATOM   2886 C C   . VAL B 1 117 ? 63.08600 89.14100 -38.13200 1.000 50.50000 ? 161 VAL B C   1 
ATOM   2887 O O   . VAL B 1 117 ? 63.77800 88.33900 -38.76000 1.000 49.78000 ? 161 VAL B O   1 
ATOM   2888 C CB  . VAL B 1 117 ? 62.29500 88.54800 -35.79800 1.000 50.85000 ? 161 VAL B CB  1 
ATOM   2889 C CG1 . VAL B 1 117 ? 62.18500 87.12000 -36.29700 1.000 46.39000 ? 161 VAL B CG1 1 
ATOM   2890 C CG2 . VAL B 1 117 ? 62.67700 88.57300 -34.32700 1.000 45.97000 ? 161 VAL B CG2 1 
ATOM   2891 N N   . ARG B 1 118 ? 62.11800 89.85500 -38.71200 1.000 49.92000 ? 162 ARG B N   1 
ATOM   2892 C CA  . ARG B 1 118 ? 61.80100 89.66700 -40.12500 1.000 48.50000 ? 162 ARG B CA  1 
ATOM   2893 C C   . ARG B 1 118 ? 62.96700 90.07300 -41.01900 1.000 49.92000 ? 162 ARG B C   1 
ATOM   2894 O O   . ARG B 1 118 ? 63.20900 89.45100 -42.06000 1.000 47.66000 ? 162 ARG B O   1 
ATOM   2895 C CB  . ARG B 1 118 ? 60.54900 90.46600 -40.49300 1.000 50.20000 ? 162 ARG B CB  1 
ATOM   2896 C CG  . ARG B 1 118 ? 59.96900 90.13400 -41.85900 1.000 51.22000 ? 162 ARG B CG  1 
ATOM   2897 C CD  . ARG B 1 118 ? 59.08800 88.89800 -41.79100 1.000 49.19000 ? 162 ARG B CD  1 
ATOM   2898 N NE  . ARG B 1 118 ? 57.97000 89.09200 -40.87600 1.000 48.05000 ? 162 ARG B NE  1 
ATOM   2899 C CZ  . ARG B 1 118 ? 56.81700 89.65300 -41.21200 1.000 48.02000 ? 162 ARG B CZ  1 
ATOM   2900 N NH1 . ARG B 1 118 ? 56.58900 90.08100 -42.44300 1.000 51.35000 ? 162 ARG B NH1 1 
ATOM   2901 N NH2 . ARG B 1 118 ? 55.86900 89.79100 -40.29000 1.000 48.53000 ? 162 ARG B NH2 1 
ATOM   2902 N N   . GLU B 1 119 ? 63.70100 91.12000 -40.62800 1.000 52.92000 ? 163 GLU B N   1 
ATOM   2903 C CA  . GLU B 1 119 ? 64.81800 91.59600 -41.43900 1.000 52.53000 ? 163 GLU B CA  1 
ATOM   2904 C C   . GLU B 1 119 ? 65.95100 90.58100 -41.50700 1.000 46.69000 ? 163 GLU B C   1 
ATOM   2905 O O   . GLU B 1 119 ? 66.66800 90.52100 -42.51200 1.000 45.47000 ? 163 GLU B O   1 
ATOM   2906 C CB  . GLU B 1 119 ? 65.34200 92.92000 -40.88000 1.000 52.84000 ? 163 GLU B CB  1 
ATOM   2907 C CG  . GLU B 1 119 ? 64.37600 94.08600 -40.99300 1.000 54.95000 ? 163 GLU B CG  1 
ATOM   2908 C CD  . GLU B 1 119 ? 64.78300 95.25500 -40.11800 1.000 57.96000 ? 163 GLU B CD  1 
ATOM   2909 O OE1 . GLU B 1 119 ? 65.90700 95.22600 -39.57200 1.000 58.30000 ? 163 GLU B OE1 1 
ATOM   2910 O OE2 . GLU B 1 119 ? 63.97900 96.19800 -39.97000 1.000 61.40000 ? 163 GLU B OE2 1 
ATOM   2911 N N   . ARG B 1 120 ? 66.13100 89.78200 -40.45700 1.000 47.85000 ? 164 ARG B N   1 
ATOM   2912 C CA  . ARG B 1 120 ? 67.25300 88.86100 -40.35100 1.000 45.09000 ? 164 ARG B CA  1 
ATOM   2913 C C   . ARG B 1 120 ? 66.89000 87.43100 -40.72900 1.000 41.64000 ? 164 ARG B C   1 
ATOM   2914 O O   . ARG B 1 120 ? 67.68400 86.51800 -40.48200 1.000 41.09000 ? 164 ARG B O   1 
ATOM   2915 C CB  . ARG B 1 120 ? 67.81600 88.88500 -38.92900 1.000 46.65000 ? 164 ARG B CB  1 
ATOM   2916 C CG  . ARG B 1 120 ? 68.32400 90.23900 -38.47300 1.000 47.45000 ? 164 ARG B CG  1 
ATOM   2917 C CD  . ARG B 1 120 ? 68.61200 90.22400 -36.98300 1.000 45.32000 ? 164 ARG B CD  1 
ATOM   2918 N NE  . ARG B 1 120 ? 69.41700 91.36300 -36.56100 1.000 45.17000 ? 164 ARG B NE  1 
ATOM   2919 C CZ  . ARG B 1 120 ? 68.92200 92.52700 -36.16400 1.000 47.56000 ? 164 ARG B CZ  1 
ATOM   2920 N NH1 . ARG B 1 120 ? 67.61800 92.74900 -36.13400 1.000 46.77000 ? 164 ARG B NH1 1 
ATOM   2921 N NH2 . ARG B 1 120 ? 69.75500 93.49300 -35.78900 1.000 50.88000 ? 164 ARG B NH2 1 
ATOM   2922 N N   . LEU B 1 121 ? 65.72100 87.21400 -41.32200 1.000 40.56000 ? 165 LEU B N   1 
ATOM   2923 C CA  . LEU B 1 121 ? 65.21000 85.87400 -41.58100 1.000 40.51000 ? 165 LEU B CA  1 
ATOM   2924 C C   . LEU B 1 121 ? 65.26400 85.57100 -43.07200 1.000 40.27000 ? 165 LEU B C   1 
ATOM   2925 O O   . LEU B 1 121 ? 64.70000 86.31500 -43.88200 1.000 40.23000 ? 165 LEU B O   1 
ATOM   2926 C CB  . LEU B 1 121 ? 63.77900 85.72900 -41.06400 1.000 37.72000 ? 165 LEU B CB  1 
ATOM   2927 C CG  . LEU B 1 121 ? 63.11300 84.38200 -41.34200 1.000 34.52000 ? 165 LEU B CG  1 
ATOM   2928 C CD1 . LEU B 1 121 ? 63.91600 83.25700 -40.71400 1.000 34.66000 ? 165 LEU B CD1 1 
ATOM   2929 C CD2 . LEU B 1 121 ? 61.68400 84.37500 -40.83000 1.000 34.16000 ? 165 LEU B CD2 1 
ATOM   2930 N N   . ASP B 1 122 ? 65.94100 84.48100 -43.42500 1.000 38.75000 ? 166 ASP B N   1 
ATOM   2931 C CA  . ASP B 1 122 ? 65.83200 83.89400 -44.75300 1.000 36.24000 ? 166 ASP B CA  1 
ATOM   2932 C C   . ASP B 1 122 ? 64.66200 82.91700 -44.72200 1.000 35.13000 ? 166 ASP B C   1 
ATOM   2933 O O   . ASP B 1 122 ? 64.79900 81.80400 -44.19900 1.000 34.86000 ? 166 ASP B O   1 
ATOM   2934 C CB  . ASP B 1 122 ? 67.13100 83.19100 -45.15300 1.000 36.47000 ? 166 ASP B CB  1 
ATOM   2935 C CG  . ASP B 1 122 ? 67.18400 82.84700 -46.63200 1.000 36.04000 ? 166 ASP B CG  1 
ATOM   2936 O OD1 . ASP B 1 122 ? 66.12200 82.57400 -47.23100 1.000 35.60000 ? 166 ASP B OD1 1 
ATOM   2937 O OD2 . ASP B 1 122 ? 68.29700 82.85000 -47.19800 1.000 39.38000 ? 166 ASP B OD2 1 
ATOM   2938 N N   . PRO B 1 123 ? 63.50100 83.29100 -45.26800 1.000 34.44000 ? 167 PRO B N   1 
ATOM   2939 C CA  . PRO B 1 123 ? 62.29500 82.47000 -45.07500 1.000 32.96000 ? 167 PRO B CA  1 
ATOM   2940 C C   . PRO B 1 123 ? 62.33900 81.12000 -45.77100 1.000 34.87000 ? 167 PRO B C   1 
ATOM   2941 O O   . PRO B 1 123 ? 61.50100 80.26300 -45.46000 1.000 35.27000 ? 167 PRO B O   1 
ATOM   2942 C CB  . PRO B 1 123 ? 61.17900 83.35000 -45.65000 1.000 31.75000 ? 167 PRO B CB  1 
ATOM   2943 C CG  . PRO B 1 123 ? 61.86500 84.19600 -46.66700 1.000 34.25000 ? 167 PRO B CG  1 
ATOM   2944 C CD  . PRO B 1 123 ? 63.24400 84.46300 -46.12300 1.000 35.73000 ? 167 PRO B CD  1 
ATOM   2945 N N   . ASN B 1 124 ? 63.27400 80.89600 -46.68900 1.000 34.85000 ? 168 ASN B N   1 
ATOM   2946 C CA  . ASN B 1 124 ? 63.35600 79.63300 -47.40900 1.000 35.19000 ? 168 ASN B CA  1 
ATOM   2947 C C   . ASN B 1 124 ? 64.25200 78.61200 -46.72000 1.000 34.79000 ? 168 ASN B C   1 
ATOM   2948 O O   . ASN B 1 124 ? 64.40400 77.49800 -47.23300 1.000 34.49000 ? 168 ASN B O   1 
ATOM   2949 C CB  . ASN B 1 124 ? 63.85200 79.87300 -48.83900 1.000 33.12000 ? 168 ASN B CB  1 
ATOM   2950 C CG  . ASN B 1 124 ? 62.96000 80.82200 -49.61300 1.000 31.38000 ? 168 ASN B CG  1 
ATOM   2951 O OD1 . ASN B 1 124 ? 61.90500 80.43200 -50.11200 1.000 33.59000 ? 168 ASN B OD1 1 
ATOM   2952 N ND2 . ASN B 1 124 ? 63.38100 82.07700 -49.71800 1.000 31.65000 ? 168 ASN B ND2 1 
ATOM   2953 N N   . ARG B 1 125 ? 64.84300 78.95900 -45.57200 1.000 34.33000 ? 169 ARG B N   1 
ATOM   2954 C CA  . ARG B 1 125 ? 65.79700 78.09500 -44.86900 1.000 33.36000 ? 169 ARG B CA  1 
ATOM   2955 C C   . ARG B 1 125 ? 65.36300 77.98100 -43.40600 1.000 33.65000 ? 169 ARG B C   1 
ATOM   2956 O O   . ARG B 1 125 ? 65.87300 78.68700 -42.53200 1.000 32.83000 ? 169 ARG B O   1 
ATOM   2957 C CB  . ARG B 1 125 ? 67.21900 78.64000 -45.01400 1.000 32.88000 ? 169 ARG B CB  1 
ATOM   2958 C CG  . ARG B 1 125 ? 67.64200 78.81900 -46.46600 1.000 34.85000 ? 169 ARG B CG  1 
ATOM   2959 C CD  . ARG B 1 125 ? 69.09500 79.23600 -46.60900 1.000 36.05000 ? 169 ARG B CD  1 
ATOM   2960 N NE  . ARG B 1 125 ? 69.35800 80.56000 -46.05800 1.000 36.18000 ? 169 ARG B NE  1 
ATOM   2961 C CZ  . ARG B 1 125 ? 70.18500 80.80000 -45.05000 1.000 37.47000 ? 169 ARG B CZ  1 
ATOM   2962 N NH1 . ARG B 1 125 ? 70.85300 79.82400 -44.45700 1.000 37.68000 ? 169 ARG B NH1 1 
ATOM   2963 N NH2 . ARG B 1 125 ? 70.35400 82.05100 -44.63400 1.000 38.36000 ? 169 ARG B NH2 1 
ATOM   2964 N N   . LEU B 1 126 ? 64.42000 77.07600 -43.14700 1.000 33.14000 ? 170 LEU B N   1 
ATOM   2965 C CA  . LEU B 1 126 ? 63.87100 76.84000 -41.82000 1.000 30.79000 ? 170 LEU B CA  1 
ATOM   2966 C C   . LEU B 1 126 ? 64.12900 75.39700 -41.40100 1.000 30.51000 ? 170 LEU B C   1 
ATOM   2967 O O   . LEU B 1 126 ? 64.42500 74.53200 -42.22900 1.000 30.01000 ? 170 LEU B O   1 
ATOM   2968 C CB  . LEU B 1 126 ? 62.36500 77.13400 -41.78400 1.000 29.24000 ? 170 LEU B CB  1 
ATOM   2969 C CG  . LEU B 1 126 ? 61.91000 78.47800 -42.36000 1.000 29.62000 ? 170 LEU B CG  1 
ATOM   2970 C CD1 . LEU B 1 126 ? 60.39200 78.57800 -42.37000 1.000 29.67000 ? 170 LEU B CD1 1 
ATOM   2971 C CD2 . LEU B 1 126 ? 62.52000 79.63400 -41.58400 1.000 30.58000 ? 170 LEU B CD2 1 
ATOM   2972 N N   . ALA B 1 127 ? 64.00700 75.14100 -40.09900 1.000 31.49000 ? 171 ALA B N   1 
ATOM   2973 C CA  . ALA B 1 127 ? 64.27900 73.82100 -39.54900 1.000 28.18000 ? 171 ALA B CA  1 
ATOM   2974 C C   . ALA B 1 127 ? 63.45500 73.63700 -38.28000 1.000 27.43000 ? 171 ALA B C   1 
ATOM   2975 O O   . ALA B 1 127 ? 62.76900 74.55500 -37.82200 1.000 27.10000 ? 171 ALA B O   1 
ATOM   2976 C CB  . ALA B 1 127 ? 65.77900 73.63600 -39.29500 1.000 26.82000 ? 171 ALA B CB  1 
ATOM   2977 N N   . VAL B 1 128 ? 63.51100 72.42700 -37.72000 1.000 27.99000 ? 172 VAL B N   1 
ATOM   2978 C CA  . VAL B 1 128 ? 62.77300 72.08700 -36.50900 1.000 24.42000 ? 172 VAL B CA  1 
ATOM   2979 C C   . VAL B 1 128 ? 63.68000 71.29100 -35.58000 1.000 23.38000 ? 172 VAL B C   1 
ATOM   2980 O O   . VAL B 1 128 ? 64.61500 70.61300 -36.01700 1.000 22.25000 ? 172 VAL B O   1 
ATOM   2981 C CB  . VAL B 1 128 ? 61.48300 71.28600 -36.80700 1.000 23.20000 ? 172 VAL B CB  1 
ATOM   2982 C CG1 . VAL B 1 128 ? 60.41300 72.18100 -37.41300 1.000 23.92000 ? 172 VAL B CG1 1 
ATOM   2983 C CG2 . VAL B 1 128 ? 61.78500 70.11500 -37.72000 1.000 23.82000 ? 172 VAL B CG2 1 
ATOM   2984 N N   . MET B 1 129 ? 63.39700 71.38400 -34.28400 1.000 23.58000 ? 173 MET B N   1 
ATOM   2985 C CA  . MET B 1 129 ? 64.09500 70.61100 -33.26800 1.000 22.84000 ? 173 MET B CA  1 
ATOM   2986 C C   . MET B 1 129 ? 63.13600 70.42000 -32.10600 1.000 20.48000 ? 173 MET B C   1 
ATOM   2987 O O   . MET B 1 129 ? 62.28700 71.27400 -31.84300 1.000 22.37000 ? 173 MET B O   1 
ATOM   2988 C CB  . MET B 1 129 ? 65.39300 71.30200 -32.81700 1.000 23.30000 ? 173 MET B CB  1 
ATOM   2989 C CG  . MET B 1 129 ? 66.20600 70.53100 -31.78000 1.000 21.34000 ? 173 MET B CG  1 
ATOM   2990 S SD  . MET B 1 129 ? 67.89800 71.13700 -31.61100 1.000 26.10000 ? 173 MET B SD  1 
ATOM   2991 C CE  . MET B 1 129 ? 67.62000 72.87700 -31.31000 1.000 22.66000 ? 173 MET B CE  1 
ATOM   2992 N N   . GLY B 1 130 ? 63.24700 69.28200 -31.43200 1.000 23.46000 ? 174 GLY B N   1 
ATOM   2993 C CA  . GLY B 1 130 ? 62.33000 68.98500 -30.35000 1.000 22.99000 ? 174 GLY B CA  1 
ATOM   2994 C C   . GLY B 1 130 ? 62.87200 67.90800 -29.44400 1.000 23.48000 ? 174 GLY B C   1 
ATOM   2995 O O   . GLY B 1 130 ? 63.65900 67.05500 -29.86600 1.000 22.91000 ? 174 GLY B O   1 
ATOM   2996 N N   . HIS B 1 131 ? 62.43400 67.94200 -28.19000 1.000 23.45000 ? 175 HIS B N   1 
ATOM   2997 C CA  . HIS B 1 131 ? 62.84700 66.98700 -27.17400 1.000 21.77000 ? 175 HIS B CA  1 
ATOM   2998 C C   . HIS B 1 131 ? 61.71100 66.01600 -26.89400 1.000 20.12000 ? 175 HIS B C   1 
ATOM   2999 O O   . HIS B 1 131 ? 60.57400 66.44000 -26.66100 1.000 21.01000 ? 175 HIS B O   1 
ATOM   3000 C CB  . HIS B 1 131 ? 63.25200 67.70600 -25.88600 1.000 22.91000 ? 175 HIS B CB  1 
ATOM   3001 C CG  . HIS B 1 131 ? 63.43900 66.78800 -24.72200 1.000 23.84000 ? 175 HIS B CG  1 
ATOM   3002 N ND1 . HIS B 1 131 ? 62.67100 66.86400 -23.58000 1.000 22.45000 ? 175 HIS B ND1 1 
ATOM   3003 C CD2 . HIS B 1 131 ? 64.30000 65.76100 -24.52800 1.000 23.95000 ? 175 HIS B CD2 1 
ATOM   3004 C CE1 . HIS B 1 131 ? 63.05500 65.92800 -22.73100 1.000 21.32000 ? 175 HIS B CE1 1 
ATOM   3005 N NE2 . HIS B 1 131 ? 64.04300 65.24500 -23.28200 1.000 22.79000 ? 175 HIS B NE2 1 
ATOM   3006 N N   . ALA B 1 132 ? 62.02300 64.71900 -26.92500 1.000 21.11000 ? 176 ALA B N   1 
ATOM   3007 C CA  . ALA B 1 132 ? 61.08400 63.66200 -26.56200 1.000 21.71000 ? 176 ALA B CA  1 
ATOM   3008 C C   . ALA B 1 132 ? 59.81400 63.69800 -27.40100 1.000 23.57000 ? 176 ALA B C   1 
ATOM   3009 O O   . ALA B 1 132 ? 59.84700 63.40400 -28.60000 1.000 23.28000 ? 176 ALA B O   1 
ATOM   3010 C CB  . ALA B 1 132 ? 60.73800 63.75800 -25.07800 1.000 22.91000 ? 176 ALA B CB  1 
ATOM   3011 N N   . MET B 1 133 ? 58.68400 64.03400 -26.77400 1.000 24.00000 ? 177 MET B N   1 
ATOM   3012 C CA  . MET B 1 133 ? 57.46000 64.21700 -27.54500 1.000 21.75000 ? 177 MET B CA  1 
ATOM   3013 C C   . MET B 1 133 ? 57.59800 65.37000 -28.52600 1.000 21.95000 ? 177 MET B C   1 
ATOM   3014 O O   . MET B 1 133 ? 56.99900 65.34000 -29.60600 1.000 24.67000 ? 177 MET B O   1 
ATOM   3015 C CB  . MET B 1 133 ? 56.27000 64.44400 -26.61700 1.000 21.48000 ? 177 MET B CB  1 
ATOM   3016 C CG  . MET B 1 133 ? 55.66300 63.16600 -26.08000 1.000 22.47000 ? 177 MET B CG  1 
ATOM   3017 S SD  . MET B 1 133 ? 53.88200 63.31200 -25.86100 1.000 27.57000 ? 177 MET B SD  1 
ATOM   3018 C CE  . MET B 1 133 ? 53.54000 61.81400 -24.95100 1.000 25.77000 ? 177 MET B CE  1 
ATOM   3019 N N   . GLY B 1 134 ? 58.38000 66.39100 -28.17400 1.000 20.85000 ? 178 GLY B N   1 
ATOM   3020 C CA  . GLY B 1 134 ? 58.73700 67.40200 -29.15100 1.000 22.71000 ? 178 GLY B CA  1 
ATOM   3021 C C   . GLY B 1 134 ? 59.64100 66.85900 -30.23500 1.000 22.90000 ? 178 GLY B C   1 
ATOM   3022 O O   . GLY B 1 134 ? 59.63500 67.36300 -31.36200 1.000 26.10000 ? 178 GLY B O   1 
ATOM   3023 N N   . GLY B 1 135 ? 60.43200 65.83400 -29.90900 1.000 23.65000 ? 179 GLY B N   1 
ATOM   3024 C CA  . GLY B 1 135 ? 61.20600 65.14700 -30.92700 1.000 22.49000 ? 179 GLY B CA  1 
ATOM   3025 C C   . GLY B 1 135 ? 60.34300 64.34300 -31.87700 1.000 21.50000 ? 179 GLY B C   1 
ATOM   3026 O O   . GLY B 1 135 ? 60.65700 64.23500 -33.06600 1.000 23.05000 ? 179 GLY B O   1 
ATOM   3027 N N   . GLY B 1 136 ? 59.25100 63.76600 -31.37300 1.000 21.66000 ? 180 GLY B N   1 
ATOM   3028 C CA  . GLY B 1 136 ? 58.27000 63.17100 -32.26300 1.000 21.06000 ? 180 GLY B CA  1 
ATOM   3029 C C   . GLY B 1 136 ? 57.56300 64.21500 -33.10500 1.000 22.44000 ? 180 GLY B C   1 
ATOM   3030 O O   . GLY B 1 136 ? 57.24500 63.97300 -34.27200 1.000 24.16000 ? 180 GLY B O   1 
ATOM   3031 N N   . GLY B 1 137 ? 57.30600 65.39000 -32.52500 1.000 21.50000 ? 181 GLY B N   1 
ATOM   3032 C CA  . GLY B 1 137 ? 56.76500 66.48800 -33.30500 1.000 21.33000 ? 181 GLY B CA  1 
ATOM   3033 C C   . GLY B 1 137 ? 57.74700 67.01700 -34.32700 1.000 23.38000 ? 181 GLY B C   1 
ATOM   3034 O O   . GLY B 1 137 ? 57.34300 67.56500 -35.35700 1.000 25.69000 ? 181 GLY B O   1 
ATOM   3035 N N   . SER B 1 138 ? 59.04500 66.86600 -34.06000 1.000 22.95000 ? 182 SER B N   1 
ATOM   3036 C CA  . SER B 1 138 ? 60.05100 67.21500 -35.05500 1.000 21.69000 ? 182 SER B CA  1 
ATOM   3037 C C   . SER B 1 138 ? 59.98900 66.26900 -36.24800 1.000 25.63000 ? 182 SER B C   1 
ATOM   3038 O O   . SER B 1 138 ? 60.14400 66.69900 -37.39700 1.000 28.73000 ? 182 SER B O   1 
ATOM   3039 C CB  . SER B 1 138 ? 61.43900 67.20000 -34.41700 1.000 21.31000 ? 182 SER B CB  1 
ATOM   3040 O OG  . SER B 1 138 ? 62.43000 67.61600 -35.33600 1.000 26.11000 ? 182 SER B OG  1 
ATOM   3041 N N   . LEU B 1 139 ? 59.75900 64.97800 -35.99500 1.000 22.84000 ? 183 LEU B N   1 
ATOM   3042 C CA  . LEU B 1 139 ? 59.53800 64.03400 -37.08700 1.000 24.29000 ? 183 LEU B CA  1 
ATOM   3043 C C   . LEU B 1 139 ? 58.23900 64.34000 -37.82200 1.000 25.74000 ? 183 LEU B C   1 
ATOM   3044 O O   . LEU B 1 139 ? 58.19200 64.29600 -39.05600 1.000 26.06000 ? 183 LEU B O   1 
ATOM   3045 C CB  . LEU B 1 139 ? 59.52000 62.60200 -36.54700 1.000 23.17000 ? 183 LEU B CB  1 
ATOM   3046 C CG  . LEU B 1 139 ? 60.83200 62.00100 -36.03900 1.000 21.94000 ? 183 LEU B CG  1 
ATOM   3047 C CD1 . LEU B 1 139 ? 60.56800 60.70500 -35.28900 1.000 20.40000 ? 183 LEU B CD1 1 
ATOM   3048 C CD2 . LEU B 1 139 ? 61.79400 61.76100 -37.19100 1.000 22.04000 ? 183 LEU B CD2 1 
ATOM   3049 N N   . GLU B 1 140 ? 57.17500 64.65100 -37.07800 1.000 24.77000 ? 184 GLU B N   1 
ATOM   3050 C CA  . GLU B 1 140 ? 55.89200 64.95900 -37.70400 1.000 25.06000 ? 184 GLU B CA  1 
ATOM   3051 C C   . GLU B 1 140 ? 55.98100 66.21100 -38.56700 1.000 27.16000 ? 184 GLU B C   1 
ATOM   3052 O O   . GLU B 1 140 ? 55.33500 66.29500 -39.61700 1.000 27.44000 ? 184 GLU B O   1 
ATOM   3053 C CB  . GLU B 1 140 ? 54.81400 65.12900 -36.63300 1.000 23.29000 ? 184 GLU B CB  1 
ATOM   3054 C CG  . GLU B 1 140 ? 54.41900 63.84300 -35.92900 1.000 25.06000 ? 184 GLU B CG  1 
ATOM   3055 C CD  . GLU B 1 140 ? 53.13500 63.25200 -36.47500 1.000 24.49000 ? 184 GLU B CD  1 
ATOM   3056 O OE1 . GLU B 1 140 ? 52.39700 63.97300 -37.17800 1.000 26.61000 ? 184 GLU B OE1 1 
ATOM   3057 O OE2 . GLU B 1 140 ? 52.86300 62.06500 -36.19800 1.000 27.01000 ? 184 GLU B OE2 1 
ATOM   3058 N N   . ALA B 1 141 ? 56.77600 67.19500 -38.13800 1.000 25.84000 ? 185 ALA B N   1 
ATOM   3059 C CA  . ALA B 1 141 ? 56.85600 68.45500 -38.86900 1.000 25.22000 ? 185 ALA B CA  1 
ATOM   3060 C C   . ALA B 1 141 ? 57.44000 68.25900 -40.26300 1.000 24.55000 ? 185 ALA B C   1 
ATOM   3061 O O   . ALA B 1 141 ? 57.01700 68.92000 -41.21700 1.000 27.80000 ? 185 ALA B O   1 
ATOM   3062 C CB  . ALA B 1 141 ? 57.68300 69.46700 -38.07800 1.000 23.12000 ? 185 ALA B CB  1 
ATOM   3063 N N   . THR B 1 142 ? 58.41300 67.35500 -40.40200 1.000 25.72000 ? 186 THR B N   1 
ATOM   3064 C CA  . THR B 1 142 ? 59.03000 67.13500 -41.70700 1.000 24.94000 ? 186 THR B CA  1 
ATOM   3065 C C   . THR B 1 142 ? 58.06800 66.47000 -42.68100 1.000 26.03000 ? 186 THR B C   1 
ATOM   3066 O O   . THR B 1 142 ? 58.19000 66.65900 -43.89600 1.000 28.21000 ? 186 THR B O   1 
ATOM   3067 C CB  . THR B 1 142 ? 60.29500 66.29100 -41.56400 1.000 24.96000 ? 186 THR B CB  1 
ATOM   3068 O OG1 . THR B 1 142 ? 59.98100 65.06000 -40.90100 1.000 27.44000 ? 186 THR B OG1 1 
ATOM   3069 C CG2 . THR B 1 142 ? 61.33400 67.04300 -40.76400 1.000 26.28000 ? 186 THR B CG2 1 
ATOM   3070 N N   . VAL B 1 143 ? 57.11900 65.68600 -42.17300 1.000 27.76000 ? 187 VAL B N   1 
ATOM   3071 C CA  . VAL B 1 143 ? 56.08700 65.12200 -43.03500 1.000 27.31000 ? 187 VAL B CA  1 
ATOM   3072 C C   . VAL B 1 143 ? 55.04800 66.18100 -43.38500 1.000 28.36000 ? 187 VAL B C   1 
ATOM   3073 O O   . VAL B 1 143 ? 54.57600 66.25100 -44.52500 1.000 28.10000 ? 187 VAL B O   1 
ATOM   3074 C CB  . VAL B 1 143 ? 55.44900 63.89400 -42.36000 1.000 26.77000 ? 187 VAL B CB  1 
ATOM   3075 C CG1 . VAL B 1 143 ? 54.27300 63.38300 -43.17500 1.000 28.07000 ? 187 VAL B CG1 1 
ATOM   3076 C CG2 . VAL B 1 143 ? 56.48700 62.79600 -42.16900 1.000 25.61000 ? 187 VAL B CG2 1 
ATOM   3077 N N   . MET B 1 144 ? 54.68900 67.02900 -42.41800 1.000 28.51000 ? 188 MET B N   1 
ATOM   3078 C CA  . MET B 1 144 ? 53.69900 68.07100 -42.67000 1.000 27.70000 ? 188 MET B CA  1 
ATOM   3079 C C   . MET B 1 144 ? 54.25700 69.18200 -43.55000 1.000 26.91000 ? 188 MET B C   1 
ATOM   3080 O O   . MET B 1 144 ? 53.50400 69.81000 -44.30300 1.000 31.24000 ? 188 MET B O   1 
ATOM   3081 C CB  . MET B 1 144 ? 53.20100 68.65100 -41.34800 1.000 28.28000 ? 188 MET B CB  1 
ATOM   3082 C CG  . MET B 1 144 ? 52.52800 67.64500 -40.43000 1.000 32.02000 ? 188 MET B CG  1 
ATOM   3083 S SD  . MET B 1 144 ? 52.31800 68.27800 -38.75400 1.000 27.14000 ? 188 MET B SD  1 
ATOM   3084 C CE  . MET B 1 144 ? 51.34900 66.96400 -38.02400 1.000 27.25000 ? 188 MET B CE  1 
ATOM   3085 N N   . ARG B 1 145 ? 55.56100 69.44400 -43.46600 1.000 26.42000 ? 189 ARG B N   1 
ATOM   3086 C CA  . ARG B 1 145 ? 56.22500 70.45300 -44.29000 1.000 26.74000 ? 189 ARG B CA  1 
ATOM   3087 C C   . ARG B 1 145 ? 57.51200 69.85100 -44.83700 1.000 26.44000 ? 189 ARG B C   1 
ATOM   3088 O O   . ARG B 1 145 ? 58.59100 70.01700 -44.25200 1.000 25.49000 ? 189 ARG B O   1 
ATOM   3089 C CB  . ARG B 1 145 ? 56.50000 71.72800 -43.49700 1.000 26.57000 ? 189 ARG B CB  1 
ATOM   3090 C CG  . ARG B 1 145 ? 57.07800 72.85600 -44.33100 1.000 26.82000 ? 189 ARG B CG  1 
ATOM   3091 C CD  . ARG B 1 145 ? 56.79400 74.19800 -43.69300 1.000 29.47000 ? 189 ARG B CD  1 
ATOM   3092 N NE  . ARG B 1 145 ? 55.36700 74.39500 -43.47300 1.000 28.42000 ? 189 ARG B NE  1 
ATOM   3093 C CZ  . ARG B 1 145 ? 54.83900 75.46400 -42.89400 1.000 26.01000 ? 189 ARG B CZ  1 
ATOM   3094 N NH1 . ARG B 1 145 ? 55.59500 76.46400 -42.47000 1.000 28.96000 ? 189 ARG B NH1 1 
ATOM   3095 N NH2 . ARG B 1 145 ? 53.52100 75.53200 -42.73500 1.000 26.88000 ? 189 ARG B NH2 1 
ATOM   3096 N N   . PRO B 1 146 ? 57.43600 69.14500 -45.96900 1.000 26.52000 ? 190 PRO B N   1 
ATOM   3097 C CA  . PRO B 1 146 ? 58.63100 68.49500 -46.52900 1.000 28.68000 ? 190 PRO B CA  1 
ATOM   3098 C C   . PRO B 1 146 ? 59.69200 69.46200 -47.03100 1.000 25.82000 ? 190 PRO B C   1 
ATOM   3099 O O   . PRO B 1 146 ? 60.76200 69.00900 -47.45400 1.000 26.76000 ? 190 PRO B O   1 
ATOM   3100 C CB  . PRO B 1 146 ? 58.06200 67.66000 -47.68900 1.000 27.85000 ? 190 PRO B CB  1 
ATOM   3101 C CG  . PRO B 1 146 ? 56.58800 67.55100 -47.41300 1.000 28.33000 ? 190 PRO B CG  1 
ATOM   3102 C CD  . PRO B 1 146 ? 56.21900 68.82300 -46.73100 1.000 26.44000 ? 190 PRO B CD  1 
ATOM   3103 N N   . SER B 1 147 ? 59.43900 70.76900 -47.00200 1.000 25.56000 ? 191 SER B N   1 
ATOM   3104 C CA  . SER B 1 147 ? 60.38900 71.76400 -47.47500 1.000 27.40000 ? 191 SER B CA  1 
ATOM   3105 C C   . SER B 1 147 ? 61.33000 72.25600 -46.38000 1.000 29.45000 ? 191 SER B C   1 
ATOM   3106 O O   . SER B 1 147 ? 62.10200 73.19000 -46.61900 1.000 31.88000 ? 191 SER B O   1 
ATOM   3107 C CB  . SER B 1 147 ? 59.64500 72.95000 -48.09800 1.000 27.81000 ? 191 SER B CB  1 
ATOM   3108 O OG  . SER B 1 147 ? 58.62900 73.43600 -47.23900 1.000 29.03000 ? 191 SER B OG  1 
ATOM   3109 N N   . LEU B 1 148 ? 61.28500 71.65400 -45.19400 1.000 28.80000 ? 192 LEU B N   1 
ATOM   3110 C CA  . LEU B 1 148 ? 62.20500 72.02900 -44.13100 1.000 28.14000 ? 192 LEU B CA  1 
ATOM   3111 C C   . LEU B 1 148 ? 63.63400 71.64800 -44.49800 1.000 27.30000 ? 192 LEU B C   1 
ATOM   3112 O O   . LEU B 1 148 ? 63.87500 70.72400 -45.28000 1.000 30.91000 ? 192 LEU B O   1 
ATOM   3113 C CB  . LEU B 1 148 ? 61.80500 71.35900 -42.81600 1.000 28.09000 ? 192 LEU B CB  1 
ATOM   3114 C CG  . LEU B 1 148 ? 60.57700 71.94000 -42.11400 1.000 27.91000 ? 192 LEU B CG  1 
ATOM   3115 C CD1 . LEU B 1 148 ? 60.18100 71.06700 -40.93800 1.000 26.42000 ? 192 LEU B CD1 1 
ATOM   3116 C CD2 . LEU B 1 148 ? 60.84600 73.36800 -41.66100 1.000 25.29000 ? 192 LEU B CD2 1 
ATOM   3117 N N   . LYS B 1 149 ? 64.59100 72.37500 -43.92000 1.000 26.06000 ? 193 LYS B N   1 
ATOM   3118 C CA  . LYS B 1 149 ? 65.99900 72.15500 -44.22700 1.000 27.52000 ? 193 LYS B CA  1 
ATOM   3119 C C   . LYS B 1 149 ? 66.64200 71.10900 -43.32500 1.000 29.66000 ? 193 LYS B C   1 
ATOM   3120 O O   . LYS B 1 149 ? 67.50400 70.34900 -43.78100 1.000 27.55000 ? 193 LYS B O   1 
ATOM   3121 C CB  . LYS B 1 149 ? 66.77400 73.47100 -44.12000 1.000 30.16000 ? 193 LYS B CB  1 
ATOM   3122 C CG  . LYS B 1 149 ? 66.44800 74.48400 -45.20600 1.000 33.78000 ? 193 LYS B CG  1 
ATOM   3123 C CD  . LYS B 1 149 ? 66.93900 74.02000 -46.56700 1.000 36.87000 ? 193 LYS B CD  1 
ATOM   3124 C CE  . LYS B 1 149 ? 66.68500 75.07400 -47.63200 1.000 39.24000 ? 193 LYS B CE  1 
ATOM   3125 N NZ  . LYS B 1 149 ? 67.22900 74.66100 -48.95500 1.000 43.76000 ? 193 LYS B NZ  1 
ATOM   3126 N N   . ALA B 1 150 ? 66.24900 71.05100 -42.05400 1.000 27.65000 ? 194 ALA B N   1 
ATOM   3127 C CA  . ALA B 1 150 ? 66.86700 70.12400 -41.11800 1.000 25.09000 ? 194 ALA B CA  1 
ATOM   3128 C C   . ALA B 1 150 ? 65.86100 69.73800 -40.04300 1.000 25.47000 ? 194 ALA B C   1 
ATOM   3129 O O   . ALA B 1 150 ? 64.84800 70.41200 -39.84000 1.000 25.10000 ? 194 ALA B O   1 
ATOM   3130 C CB  . ALA B 1 150 ? 68.12600 70.72500 -40.48300 1.000 23.99000 ? 194 ALA B CB  1 
ATOM   3131 N N   . SER B 1 151 ? 66.16000 68.63800 -39.35400 1.000 25.18000 ? 195 SER B N   1 
ATOM   3132 C CA  . SER B 1 151 ? 65.31700 68.13500 -38.27600 1.000 23.02000 ? 195 SER B CA  1 
ATOM   3133 C C   . SER B 1 151 ? 66.19800 67.42900 -37.25900 1.000 22.77000 ? 195 SER B C   1 
ATOM   3134 O O   . SER B 1 151 ? 67.04400 66.61200 -37.63300 1.000 21.90000 ? 195 SER B O   1 
ATOM   3135 C CB  . SER B 1 151 ? 64.24700 67.17800 -38.80700 1.000 24.16000 ? 195 SER B CB  1 
ATOM   3136 O OG  . SER B 1 151 ? 63.47200 66.63600 -37.75100 1.000 23.37000 ? 195 SER B OG  1 
ATOM   3137 N N   . ILE B 1 152 ? 66.00900 67.75000 -35.98200 1.000 26.23000 ? 196 ILE B N   1 
ATOM   3138 C CA  . ILE B 1 152 ? 66.81100 67.15200 -34.91600 1.000 23.60000 ? 196 ILE B CA  1 
ATOM   3139 C C   . ILE B 1 152 ? 65.90200 66.66900 -33.79100 1.000 24.61000 ? 196 ILE B C   1 
ATOM   3140 O O   . ILE B 1 152 ? 65.62000 67.42900 -32.85300 1.000 24.12000 ? 196 ILE B O   1 
ATOM   3141 C CB  . ILE B 1 152 ? 67.86200 68.14000 -34.38100 1.000 24.04000 ? 196 ILE B CB  1 
ATOM   3142 C CG1 . ILE B 1 152 ? 68.71100 68.70100 -35.52600 1.000 22.18000 ? 196 ILE B CG1 1 
ATOM   3143 C CG2 . ILE B 1 152 ? 68.75100 67.46000 -33.34700 1.000 21.03000 ? 196 ILE B CG2 1 
ATOM   3144 C CD1 . ILE B 1 152 ? 69.77400 69.68300 -35.08700 1.000 23.99000 ? 196 ILE B CD1 1 
ATOM   3145 N N   . PRO B 1 153 ? 65.40700 65.43100 -33.84500 1.000 24.61000 ? 197 PRO B N   1 
ATOM   3146 C CA  . PRO B 1 153 ? 64.66100 64.87500 -32.70400 1.000 23.54000 ? 197 PRO B CA  1 
ATOM   3147 C C   . PRO B 1 153 ? 65.60900 64.49500 -31.57400 1.000 22.67000 ? 197 PRO B C   1 
ATOM   3148 O O   . PRO B 1 153 ? 66.48600 63.64400 -31.74400 1.000 20.84000 ? 197 PRO B O   1 
ATOM   3149 C CB  . PRO B 1 153 ? 63.96500 63.64300 -33.29900 1.000 22.75000 ? 197 PRO B CB  1 
ATOM   3150 C CG  . PRO B 1 153 ? 64.02900 63.83100 -34.78900 1.000 22.22000 ? 197 PRO B CG  1 
ATOM   3151 C CD  . PRO B 1 153 ? 65.29700 64.57900 -35.03800 1.000 22.74000 ? 197 PRO B CD  1 
ATOM   3152 N N   . LEU B 1 154 ? 65.42600 65.12700 -30.41700 1.000 23.74000 ? 198 LEU B N   1 
ATOM   3153 C CA  . LEU B 1 154 ? 66.25900 64.89100 -29.24300 1.000 23.52000 ? 198 LEU B CA  1 
ATOM   3154 C C   . LEU B 1 154 ? 65.56300 63.89300 -28.32700 1.000 21.69000 ? 198 LEU B C   1 
ATOM   3155 O O   . LEU B 1 154 ? 64.49700 64.19400 -27.77800 1.000 23.68000 ? 198 LEU B O   1 
ATOM   3156 C CB  . LEU B 1 154 ? 66.53100 66.19800 -28.49900 1.000 22.44000 ? 198 LEU B CB  1 
ATOM   3157 C CG  . LEU B 1 154 ? 67.23500 67.30400 -29.28400 1.000 22.01000 ? 198 LEU B CG  1 
ATOM   3158 C CD1 . LEU B 1 154 ? 67.28700 68.58800 -28.47400 1.000 24.23000 ? 198 LEU B CD1 1 
ATOM   3159 C CD2 . LEU B 1 154 ? 68.63000 66.86000 -29.67200 1.000 22.95000 ? 198 LEU B CD2 1 
ATOM   3160 N N   . THR B 1 155 ? 66.17700 62.72200 -28.15000 1.000 21.88000 ? 199 THR B N   1 
ATOM   3161 C CA  . THR B 1 155 ? 65.62400 61.59400 -27.40300 1.000 22.15000 ? 199 THR B CA  1 
ATOM   3162 C C   . THR B 1 155 ? 64.13500 61.42300 -27.73100 1.000 23.66000 ? 199 THR B C   1 
ATOM   3163 O O   . THR B 1 155 ? 63.29000 61.47900 -26.83100 1.000 23.95000 ? 199 THR B O   1 
ATOM   3164 C CB  . THR B 1 155 ? 65.83900 61.75900 -25.90200 1.000 20.73000 ? 199 THR B CB  1 
ATOM   3165 O OG1 . THR B 1 155 ? 65.18400 62.95000 -25.44800 1.000 22.47000 ? 199 THR B OG1 1 
ATOM   3166 C CG2 . THR B 1 155 ? 67.32500 61.85000 -25.58000 1.000 21.13000 ? 199 THR B CG2 1 
ATOM   3167 N N   . PRO B 1 156 ? 63.78900 61.20300 -28.99900 1.000 24.32000 ? 200 PRO B N   1 
ATOM   3168 C CA  . PRO B 1 156 ? 62.39200 61.35300 -29.41800 1.000 21.31000 ? 200 PRO B CA  1 
ATOM   3169 C C   . PRO B 1 156 ? 61.49500 60.24800 -28.89000 1.000 19.54000 ? 200 PRO B C   1 
ATOM   3170 O O   . PRO B 1 156 ? 61.90900 59.10000 -28.71300 1.000 20.51000 ? 200 PRO B O   1 
ATOM   3171 C CB  . PRO B 1 156 ? 62.47900 61.30400 -30.94600 1.000 22.34000 ? 200 PRO B CB  1 
ATOM   3172 C CG  . PRO B 1 156 ? 63.66200 60.44300 -31.21100 1.000 19.77000 ? 200 PRO B CG  1 
ATOM   3173 C CD  . PRO B 1 156 ? 64.64700 60.73900 -30.10500 1.000 22.67000 ? 200 PRO B CD  1 
ATOM   3174 N N   . TRP B 1 157 ? 60.24100 60.61700 -28.64600 1.000 20.71000 ? 201 TRP B N   1 
ATOM   3175 C CA  . TRP B 1 157 ? 59.18900 59.68100 -28.27900 1.000 20.31000 ? 201 TRP B CA  1 
ATOM   3176 C C   . TRP B 1 157 ? 58.08600 59.76500 -29.32200 1.000 17.36000 ? 201 TRP B C   1 
ATOM   3177 O O   . TRP B 1 157 ? 57.58500 60.85700 -29.61200 1.000 18.93000 ? 201 TRP B O   1 
ATOM   3178 C CB  . TRP B 1 157 ? 58.62900 59.98900 -26.88600 1.000 20.06000 ? 201 TRP B CB  1 
ATOM   3179 C CG  . TRP B 1 157 ? 57.63000 58.98300 -26.40000 1.000 18.28000 ? 201 TRP B CG  1 
ATOM   3180 C CD1 . TRP B 1 157 ? 57.86800 57.93400 -25.56200 1.000 20.08000 ? 201 TRP B CD1 1 
ATOM   3181 C CD2 . TRP B 1 157 ? 56.23300 58.92900 -26.72200 1.000 19.56000 ? 201 TRP B CD2 1 
ATOM   3182 N NE1 . TRP B 1 157 ? 56.70900 57.23000 -25.34300 1.000 19.23000 ? 201 TRP B NE1 1 
ATOM   3183 C CE2 . TRP B 1 157 ? 55.69100 57.82100 -26.04300 1.000 20.21000 ? 201 TRP B CE2 1 
ATOM   3184 C CE3 . TRP B 1 157 ? 55.38900 59.71100 -27.51800 1.000 20.18000 ? 201 TRP B CE3 1 
ATOM   3185 C CZ2 . TRP B 1 157 ? 54.34500 57.47400 -26.13500 1.000 23.01000 ? 201 TRP B CZ2 1 
ATOM   3186 C CZ3 . TRP B 1 157 ? 54.05400 59.36400 -27.61000 1.000 20.09000 ? 201 TRP B CZ3 1 
ATOM   3187 C CH2 . TRP B 1 157 ? 53.54400 58.25600 -26.92100 1.000 23.02000 ? 201 TRP B CH2 1 
ATOM   3188 N N   . HIS B 1 158 ? 57.71300 58.61800 -29.88500 1.000 20.17000 ? 202 HIS B N   1 
ATOM   3189 C CA  . HIS B 1 158 ? 56.62500 58.57100 -30.85000 1.000 19.54000 ? 202 HIS B CA  1 
ATOM   3190 C C   . HIS B 1 158 ? 56.14300 57.13400 -30.97500 1.000 19.30000 ? 202 HIS B C   1 
ATOM   3191 O O   . HIS B 1 158 ? 56.94100 56.19700 -30.89800 1.000 21.68000 ? 202 HIS B O   1 
ATOM   3192 C CB  . HIS B 1 158 ? 57.06200 59.11200 -32.21700 1.000 19.95000 ? 202 HIS B CB  1 
ATOM   3193 C CG  . HIS B 1 158 ? 55.93600 59.65500 -33.04100 1.000 19.75000 ? 202 HIS B CG  1 
ATOM   3194 N ND1 . HIS B 1 158 ? 54.80600 58.92300 -33.33300 1.000 21.92000 ? 202 HIS B ND1 1 
ATOM   3195 C CD2 . HIS B 1 158 ? 55.76700 60.85900 -33.63600 1.000 19.41000 ? 202 HIS B CD2 1 
ATOM   3196 C CE1 . HIS B 1 158 ? 53.98800 59.65300 -34.07000 1.000 21.15000 ? 202 HIS B CE1 1 
ATOM   3197 N NE2 . HIS B 1 158 ? 54.54800 60.83200 -34.26800 1.000 19.80000 ? 202 HIS B NE2 1 
ATOM   3198 N N   . LEU B 1 159 ? 54.83100 56.97200 -31.15600 1.000 21.07000 ? 203 LEU B N   1 
ATOM   3199 C CA  . LEU B 1 159 ? 54.25900 55.64600 -31.35500 1.000 22.94000 ? 203 LEU B CA  1 
ATOM   3200 C C   . LEU B 1 159 ? 54.47400 55.15100 -32.77900 1.000 26.41000 ? 203 LEU B C   1 
ATOM   3201 O O   . LEU B 1 159 ? 54.70300 53.95700 -32.99500 1.000 28.53000 ? 203 LEU B O   1 
ATOM   3202 C CB  . LEU B 1 159 ? 52.77000 55.66500 -31.02500 1.000 24.63000 ? 203 LEU B CB  1 
ATOM   3203 C CG  . LEU B 1 159 ? 52.42000 56.13300 -29.61800 1.000 29.81000 ? 203 LEU B CG  1 
ATOM   3204 C CD1 . LEU B 1 159 ? 50.98100 56.60000 -29.60000 1.000 28.21000 ? 203 LEU B CD1 1 
ATOM   3205 C CD2 . LEU B 1 159 ? 52.65200 55.01500 -28.60700 1.000 30.48000 ? 203 LEU B CD2 1 
ATOM   3206 N N   . ASP B 1 160 ? 54.39100 56.04700 -33.75700 1.000 28.58000 ? 204 ASP B N   1 
ATOM   3207 C CA  . ASP B 1 160 ? 54.64400 55.68800 -35.14700 1.000 27.03000 ? 204 ASP B CA  1 
ATOM   3208 C C   . ASP B 1 160 ? 56.14300 55.51200 -35.35400 1.000 23.44000 ? 204 ASP B C   1 
ATOM   3209 O O   . ASP B 1 160 ? 56.91800 56.45100 -35.14700 1.000 24.06000 ? 204 ASP B O   1 
ATOM   3210 C CB  . ASP B 1 160 ? 54.08700 56.76400 -36.07500 1.000 29.26000 ? 204 ASP B CB  1 
ATOM   3211 C CG  . ASP B 1 160 ? 54.10500 56.35200 -37.53500 1.000 32.49000 ? 204 ASP B CG  1 
ATOM   3212 O OD1 . ASP B 1 160 ? 54.36800 55.16400 -37.82900 1.000 31.95000 ? 204 ASP B OD1 1 
ATOM   3213 O OD2 . ASP B 1 160 ? 53.85400 57.22400 -38.38900 1.000 37.93000 ? 204 ASP B OD2 1 
ATOM   3214 N N   . LYS B 1 161 ? 56.55200 54.30900 -35.75400 1.000 28.63000 ? 205 LYS B N   1 
ATOM   3215 C CA  . LYS B 1 161 ? 57.96100 53.96700 -35.89200 1.000 28.48000 ? 205 LYS B CA  1 
ATOM   3216 C C   . LYS B 1 161 ? 58.44200 53.96800 -37.33900 1.000 25.76000 ? 205 LYS B C   1 
ATOM   3217 O O   . LYS B 1 161 ? 59.61200 53.66300 -37.58600 1.000 27.23000 ? 205 LYS B O   1 
ATOM   3218 C CB  . LYS B 1 161 ? 58.23000 52.59400 -35.26600 1.000 27.89000 ? 205 LYS B CB  1 
ATOM   3219 C CG  . LYS B 1 161 ? 57.53000 52.35700 -33.93400 1.000 28.47000 ? 205 LYS B CG  1 
ATOM   3220 C CD  . LYS B 1 161 ? 58.12000 53.20500 -32.82000 1.000 25.98000 ? 205 LYS B CD  1 
ATOM   3221 C CE  . LYS B 1 161 ? 57.44100 52.91000 -31.49200 1.000 24.86000 ? 205 LYS B CE  1 
ATOM   3222 N NZ  . LYS B 1 161 ? 58.16500 53.54500 -30.35800 1.000 22.71000 ? 205 LYS B NZ  1 
ATOM   3223 N N   . THR B 1 162 ? 57.57900 54.30200 -38.29500 1.000 29.31000 ? 206 THR B N   1 
ATOM   3224 C CA  . THR B 1 162 ? 57.91400 54.26800 -39.71300 1.000 27.67000 ? 206 THR B CA  1 
ATOM   3225 C C   . THR B 1 162 ? 57.91500 55.68200 -40.27700 1.000 25.53000 ? 206 THR B C   1 
ATOM   3226 O O   . THR B 1 162 ? 56.91800 56.40100 -40.16200 1.000 27.82000 ? 206 THR B O   1 
ATOM   3227 C CB  . THR B 1 162 ? 56.92700 53.39500 -40.49100 1.000 28.72000 ? 206 THR B CB  1 
ATOM   3228 O OG1 . THR B 1 162 ? 56.99300 52.04900 -40.00600 1.000 31.28000 ? 206 THR B OG1 1 
ATOM   3229 C CG2 . THR B 1 162 ? 57.25500 53.41000 -41.97800 1.000 31.50000 ? 206 THR B CG2 1 
ATOM   3230 N N   . TRP B 1 163 ? 59.03100 56.07000 -40.89400 1.000 24.03000 ? 207 TRP B N   1 
ATOM   3231 C CA  . TRP B 1 163 ? 59.20200 57.41300 -41.43900 1.000 26.12000 ? 207 TRP B CA  1 
ATOM   3232 C C   . TRP B 1 163 ? 59.88400 57.35400 -42.79800 1.000 24.00000 ? 207 TRP B C   1 
ATOM   3233 O O   . TRP B 1 163 ? 60.80000 58.13100 -43.08800 1.000 23.67000 ? 207 TRP B O   1 
ATOM   3234 C CB  . TRP B 1 163 ? 59.99300 58.29500 -40.47500 1.000 25.19000 ? 207 TRP B CB  1 
ATOM   3235 C CG  . TRP B 1 163 ? 59.35800 58.39700 -39.12700 1.000 25.30000 ? 207 TRP B CG  1 
ATOM   3236 C CD1 . TRP B 1 163 ? 59.62200 57.62300 -38.03400 1.000 24.11000 ? 207 TRP B CD1 1 
ATOM   3237 C CD2 . TRP B 1 163 ? 58.33400 59.31500 -38.73100 1.000 24.93000 ? 207 TRP B CD2 1 
ATOM   3238 N NE1 . TRP B 1 163 ? 58.83100 58.01000 -36.97900 1.000 24.78000 ? 207 TRP B NE1 1 
ATOM   3239 C CE2 . TRP B 1 163 ? 58.03100 59.04700 -37.38100 1.000 24.55000 ? 207 TRP B CE2 1 
ATOM   3240 C CE3 . TRP B 1 163 ? 57.64800 60.34300 -39.38500 1.000 23.14000 ? 207 TRP B CE3 1 
ATOM   3241 C CZ2 . TRP B 1 163 ? 57.07200 59.76800 -36.67500 1.000 23.61000 ? 207 TRP B CZ2 1 
ATOM   3242 C CZ3 . TRP B 1 163 ? 56.69600 61.05700 -38.68300 1.000 25.63000 ? 207 TRP B CZ3 1 
ATOM   3243 C CH2 . TRP B 1 163 ? 56.41600 60.76600 -37.34200 1.000 24.59000 ? 207 TRP B CH2 1 
ATOM   3244 N N   . GLY B 1 164 ? 59.44200 56.43400 -43.65400 1.000 25.54000 ? 208 GLY B N   1 
ATOM   3245 C CA  . GLY B 1 164 ? 60.05900 56.23100 -44.95000 1.000 26.99000 ? 208 GLY B CA  1 
ATOM   3246 C C   . GLY B 1 164 ? 59.76600 57.29300 -45.98400 1.000 24.69000 ? 208 GLY B C   1 
ATOM   3247 O O   . GLY B 1 164 ? 60.31200 57.22300 -47.08900 1.000 28.26000 ? 208 GLY B O   1 
ATOM   3248 N N   . GLN B 1 165 ? 58.92100 58.27100 -45.66500 1.000 25.58000 ? 209 GLN B N   1 
ATOM   3249 C CA  . GLN B 1 165 ? 58.59000 59.34900 -46.58600 1.000 23.11000 ? 209 GLN B CA  1 
ATOM   3250 C C   . GLN B 1 165 ? 59.31500 60.64900 -46.26700 1.000 24.03000 ? 209 GLN B C   1 
ATOM   3251 O O   . GLN B 1 165 ? 59.18200 61.61600 -47.02400 1.000 26.45000 ? 209 GLN B O   1 
ATOM   3252 C CB  . GLN B 1 165 ? 57.07600 59.59100 -46.59600 1.000 25.09000 ? 209 GLN B CB  1 
ATOM   3253 C CG  . GLN B 1 165 ? 56.27200 58.46000 -47.22600 1.000 27.43000 ? 209 GLN B CG  1 
ATOM   3254 C CD  . GLN B 1 165 ? 56.60100 58.25900 -48.69400 1.000 24.87000 ? 209 GLN B CD  1 
ATOM   3255 O OE1 . GLN B 1 165 ? 56.67600 59.21900 -49.46000 1.000 26.72000 ? 209 GLN B OE1 1 
ATOM   3256 N NE2 . GLN B 1 165 ? 56.81100 57.00800 -49.09100 1.000 21.78000 ? 209 GLN B NE2 1 
ATOM   3257 N N   . VAL B 1 166 ? 60.07900 60.69500 -45.17500 1.000 25.72000 ? 210 VAL B N   1 
ATOM   3258 C CA  . VAL B 1 166 ? 60.78800 61.91300 -44.80300 1.000 24.83000 ? 210 VAL B CA  1 
ATOM   3259 C C   . VAL B 1 166 ? 61.91000 62.17400 -45.79800 1.000 22.91000 ? 210 VAL B C   1 
ATOM   3260 O O   . VAL B 1 166 ? 62.69900 61.27600 -46.11900 1.000 23.52000 ? 210 VAL B O   1 
ATOM   3261 C CB  . VAL B 1 166 ? 61.32300 61.80500 -43.36700 1.000 21.70000 ? 210 VAL B CB  1 
ATOM   3262 C CG1 . VAL B 1 166 ? 62.27200 62.95100 -43.06400 1.000 21.75000 ? 210 VAL B CG1 1 
ATOM   3263 C CG2 . VAL B 1 166 ? 60.17100 61.79200 -42.37300 1.000 20.73000 ? 210 VAL B CG2 1 
ATOM   3264 N N   . GLN B 1 167 ? 61.97800 63.40700 -46.30000 1.000 22.15000 ? 211 GLN B N   1 
ATOM   3265 C CA  . GLN B 1 167 ? 63.03300 63.82000 -47.21500 1.000 23.67000 ? 211 GLN B CA  1 
ATOM   3266 C C   . GLN B 1 167 ? 63.88800 64.94300 -46.64200 1.000 24.47000 ? 211 GLN B C   1 
ATOM   3267 O O   . GLN B 1 167 ? 64.76400 65.46200 -47.34200 1.000 24.72000 ? 211 GLN B O   1 
ATOM   3268 C CB  . GLN B 1 167 ? 62.43800 64.24800 -48.56000 1.000 24.54000 ? 211 GLN B CB  1 
ATOM   3269 C CG  . GLN B 1 167 ? 61.53300 65.46400 -48.48200 1.000 25.97000 ? 211 GLN B CG  1 
ATOM   3270 C CD  . GLN B 1 167 ? 61.00300 65.87600 -49.84000 1.000 24.31000 ? 211 GLN B CD  1 
ATOM   3271 O OE1 . GLN B 1 167 ? 61.03400 65.09700 -50.79400 1.000 25.37000 ? 211 GLN B OE1 1 
ATOM   3272 N NE2 . GLN B 1 167 ? 60.51600 67.10700 -49.93700 1.000 24.06000 ? 211 GLN B NE2 1 
ATOM   3273 N N   . VAL B 1 168 ? 63.65900 65.32600 -45.38900 1.000 28.24000 ? 212 VAL B N   1 
ATOM   3274 C CA  . VAL B 1 168 ? 64.43000 66.37400 -44.72500 1.000 26.53000 ? 212 VAL B CA  1 
ATOM   3275 C C   . VAL B 1 168 ? 65.57900 65.72200 -43.96500 1.000 26.26000 ? 212 VAL B C   1 
ATOM   3276 O O   . VAL B 1 168 ? 65.37000 64.69800 -43.29700 1.000 28.76000 ? 212 VAL B O   1 
ATOM   3277 C CB  . VAL B 1 168 ? 63.54000 67.20600 -43.78700 1.000 24.75000 ? 212 VAL B CB  1 
ATOM   3278 C CG1 . VAL B 1 168 ? 64.34800 68.28400 -43.09100 1.000 25.16000 ? 212 VAL B CG1 1 
ATOM   3279 C CG2 . VAL B 1 168 ? 62.38100 67.81700 -44.56300 1.000 25.97000 ? 212 VAL B CG2 1 
ATOM   3280 N N   . PRO B 1 169 ? 66.80000 66.25300 -44.05000 1.000 25.98000 ? 213 PRO B N   1 
ATOM   3281 C CA  . PRO B 1 169 ? 67.90800 65.68500 -43.27000 1.000 25.94000 ? 213 PRO B CA  1 
ATOM   3282 C C   . PRO B 1 169 ? 67.58900 65.67100 -41.78100 1.000 24.77000 ? 213 PRO B C   1 
ATOM   3283 O O   . PRO B 1 169 ? 67.21900 66.69200 -41.19700 1.000 23.21000 ? 213 PRO B O   1 
ATOM   3284 C CB  . PRO B 1 169 ? 69.08000 66.61700 -43.59500 1.000 24.35000 ? 213 PRO B CB  1 
ATOM   3285 C CG  . PRO B 1 169 ? 68.74800 67.17300 -44.93800 1.000 25.26000 ? 213 PRO B CG  1 
ATOM   3286 C CD  . PRO B 1 169 ? 67.25300 67.32200 -44.95700 1.000 25.33000 ? 213 PRO B CD  1 
ATOM   3287 N N   . THR B 1 170 ? 67.73800 64.49700 -41.17000 1.000 24.93000 ? 214 THR B N   1 
ATOM   3288 C CA  . THR B 1 170 ? 67.30500 64.25300 -39.80000 1.000 24.33000 ? 214 THR B CA  1 
ATOM   3289 C C   . THR B 1 170 ? 68.47300 63.74800 -38.96500 1.000 23.44000 ? 214 THR B C   1 
ATOM   3290 O O   . THR B 1 170 ? 69.17200 62.81400 -39.36800 1.000 22.25000 ? 214 THR B O   1 
ATOM   3291 C CB  . THR B 1 170 ? 66.15300 63.24300 -39.76500 1.000 23.47000 ? 214 THR B CB  1 
ATOM   3292 O OG1 . THR B 1 170 ? 65.01300 63.79100 -40.44000 1.000 24.98000 ? 214 THR B OG1 1 
ATOM   3293 C CG2 . THR B 1 170 ? 65.77100 62.90700 -38.33200 1.000 23.22000 ? 214 THR B CG2 1 
ATOM   3294 N N   . PHE B 1 171 ? 68.67200 64.36500 -37.80000 1.000 24.95000 ? 215 PHE B N   1 
ATOM   3295 C CA  . PHE B 1 171 ? 69.71300 63.99100 -36.84600 1.000 22.44000 ? 215 PHE B CA  1 
ATOM   3296 C C   . PHE B 1 171 ? 69.03300 63.58300 -35.54500 1.000 22.26000 ? 215 PHE B C   1 
ATOM   3297 O O   . PHE B 1 171 ? 68.49900 64.43400 -34.82800 1.000 22.01000 ? 215 PHE B O   1 
ATOM   3298 C CB  . PHE B 1 171 ? 70.68100 65.15000 -36.61700 1.000 21.89000 ? 215 PHE B CB  1 
ATOM   3299 C CG  . PHE B 1 171 ? 71.82200 64.82800 -35.69100 1.000 20.78000 ? 215 PHE B CG  1 
ATOM   3300 C CD1 . PHE B 1 171 ? 72.23100 63.52000 -35.48400 1.000 21.37000 ? 215 PHE B CD1 1 
ATOM   3301 C CD2 . PHE B 1 171 ? 72.48700 65.84400 -35.02600 1.000 23.97000 ? 215 PHE B CD2 1 
ATOM   3302 C CE1 . PHE B 1 171 ? 73.28100 63.23500 -34.63300 1.000 21.55000 ? 215 PHE B CE1 1 
ATOM   3303 C CE2 . PHE B 1 171 ? 73.53700 65.56500 -34.17400 1.000 23.68000 ? 215 PHE B CE2 1 
ATOM   3304 C CZ  . PHE B 1 171 ? 73.93500 64.25900 -33.97800 1.000 20.52000 ? 215 PHE B CZ  1 
ATOM   3305 N N   . ILE B 1 172 ? 69.06300 62.29200 -35.23500 1.000 22.30000 ? 216 ILE B N   1 
ATOM   3306 C CA  . ILE B 1 172 ? 68.40800 61.75500 -34.04900 1.000 23.53000 ? 216 ILE B CA  1 
ATOM   3307 C C   . ILE B 1 172 ? 69.46300 61.51800 -32.97800 1.000 22.56000 ? 216 ILE B C   1 
ATOM   3308 O O   . ILE B 1 172 ? 70.42400 60.77100 -33.19400 1.000 22.50000 ? 216 ILE B O   1 
ATOM   3309 C CB  . ILE B 1 172 ? 67.64200 60.46300 -34.36900 1.000 22.83000 ? 216 ILE B CB  1 
ATOM   3310 C CG1 . ILE B 1 172 ? 66.51500 60.75600 -35.36300 1.000 20.49000 ? 216 ILE B CG1 1 
ATOM   3311 C CG2 . ILE B 1 172 ? 67.09800 59.83500 -33.09300 1.000 23.00000 ? 216 ILE B CG2 1 
ATOM   3312 C CD1 . ILE B 1 172 ? 65.71200 59.54200 -35.75900 1.000 20.84000 ? 216 ILE B CD1 1 
ATOM   3313 N N   . ILE B 1 173 ? 69.29000 62.15600 -31.82500 1.000 24.33000 ? 217 ILE B N   1 
ATOM   3314 C CA  . ILE B 1 173 ? 70.18500 61.99000 -30.68700 1.000 21.71000 ? 217 ILE B CA  1 
ATOM   3315 C C   . ILE B 1 173 ? 69.46800 61.13600 -29.65200 1.000 23.09000 ? 217 ILE B C   1 
ATOM   3316 O O   . ILE B 1 173 ? 68.38100 61.49500 -29.18400 1.000 22.57000 ? 217 ILE B O   1 
ATOM   3317 C CB  . ILE B 1 173 ? 70.61300 63.34100 -30.09500 1.000 24.11000 ? 217 ILE B CB  1 
ATOM   3318 C CG1 . ILE B 1 173 ? 71.43700 64.12900 -31.11600 1.000 21.26000 ? 217 ILE B CG1 1 
ATOM   3319 C CG2 . ILE B 1 173 ? 71.39900 63.13000 -28.80900 1.000 24.41000 ? 217 ILE B CG2 1 
ATOM   3320 C CD1 . ILE B 1 173 ? 71.86900 65.50000 -30.63900 1.000 19.98000 ? 217 ILE B CD1 1 
ATOM   3321 N N   . GLY B 1 174 ? 70.06900 60.00200 -29.30600 1.000 23.60000 ? 218 GLY B N   1 
ATOM   3322 C CA  . GLY B 1 174 ? 69.48700 59.11200 -28.32300 1.000 25.68000 ? 218 GLY B CA  1 
ATOM   3323 C C   . GLY B 1 174 ? 70.30100 59.05100 -27.04900 1.000 23.27000 ? 218 GLY B C   1 
ATOM   3324 O O   . GLY B 1 174 ? 71.48300 59.40400 -27.04300 1.000 22.69000 ? 218 GLY B O   1 
ATOM   3325 N N   . ALA B 1 175 ? 69.67700 58.61300 -25.96100 1.000 25.97000 ? 219 ALA B N   1 
ATOM   3326 C CA  . ALA B 1 175 ? 70.34100 58.46900 -24.67400 1.000 24.27000 ? 219 ALA B CA  1 
ATOM   3327 C C   . ALA B 1 175 ? 70.46200 56.99000 -24.34100 1.000 21.17000 ? 219 ALA B C   1 
ATOM   3328 O O   . ALA B 1 175 ? 69.48300 56.24500 -24.45300 1.000 22.57000 ? 219 ALA B O   1 
ATOM   3329 C CB  . ALA B 1 175 ? 69.57300 59.20200 -23.57400 1.000 24.80000 ? 219 ALA B CB  1 
ATOM   3330 N N   . GLU B 1 176 ? 71.66200 56.57300 -23.93100 1.000 22.55000 ? 220 GLU B N   1 
ATOM   3331 C CA  . GLU B 1 176 ? 71.91800 55.15400 -23.70000 1.000 24.50000 ? 220 GLU B CA  1 
ATOM   3332 C C   . GLU B 1 176 ? 70.97500 54.58400 -22.64700 1.000 27.40000 ? 220 GLU B C   1 
ATOM   3333 O O   . GLU B 1 176 ? 70.38400 53.51500 -22.84100 1.000 27.41000 ? 220 GLU B O   1 
ATOM   3334 C CB  . GLU B 1 176 ? 73.37500 54.94800 -23.28800 1.000 25.14000 ? 220 GLU B CB  1 
ATOM   3335 C CG  . GLU B 1 176 ? 73.75900 53.50000 -23.05100 1.000 25.80000 ? 220 GLU B CG  1 
ATOM   3336 C CD  . GLU B 1 176 ? 75.19500 53.35300 -22.59100 1.000 27.00000 ? 220 GLU B CD  1 
ATOM   3337 O OE1 . GLU B 1 176 ? 75.78700 54.36400 -22.16000 1.000 30.37000 ? 220 GLU B OE1 1 
ATOM   3338 O OE2 . GLU B 1 176 ? 75.73300 52.22800 -22.66300 1.000 30.61000 ? 220 GLU B OE2 1 
ATOM   3339 N N   . LEU B 1 177 ? 70.81000 55.29100 -21.52700 1.000 29.05000 ? 221 LEU B N   1 
ATOM   3340 C CA  . LEU B 1 177 ? 70.02200 54.80600 -20.40100 1.000 27.80000 ? 221 LEU B CA  1 
ATOM   3341 C C   . LEU B 1 177 ? 68.62200 55.40800 -20.36500 1.000 27.01000 ? 221 LEU B C   1 
ATOM   3342 O O   . LEU B 1 177 ? 68.04600 55.57800 -19.28500 1.000 27.48000 ? 221 LEU B O   1 
ATOM   3343 C CB  . LEU B 1 177 ? 70.75500 55.08300 -19.08800 1.000 27.91000 ? 221 LEU B CB  1 
ATOM   3344 C CG  . LEU B 1 177 ? 72.20400 54.59500 -19.03300 1.000 28.69000 ? 221 LEU B CG  1 
ATOM   3345 C CD1 . LEU B 1 177 ? 72.81000 54.83800 -17.65800 1.000 28.19000 ? 221 LEU B CD1 1 
ATOM   3346 C CD2 . LEU B 1 177 ? 72.29400 53.12400 -19.41300 1.000 27.92000 ? 221 LEU B CD2 1 
ATOM   3347 N N   . ASP B 1 178 ? 68.06100 55.73100 -21.52700 1.000 26.41000 ? 222 ASP B N   1 
ATOM   3348 C CA  . ASP B 1 178 ? 66.70500 56.25700 -21.60200 1.000 23.21000 ? 222 ASP B CA  1 
ATOM   3349 C C   . ASP B 1 178 ? 65.71700 55.11100 -21.41900 1.000 23.68000 ? 222 ASP B C   1 
ATOM   3350 O O   . ASP B 1 178 ? 65.76400 54.11700 -22.15200 1.000 24.08000 ? 222 ASP B O   1 
ATOM   3351 C CB  . ASP B 1 178 ? 66.48200 56.96500 -22.93700 1.000 23.41000 ? 222 ASP B CB  1 
ATOM   3352 C CG  . ASP B 1 178 ? 65.21300 57.80400 -22.95800 1.000 22.23000 ? 222 ASP B CG  1 
ATOM   3353 O OD1 . ASP B 1 178 ? 64.23200 57.44600 -22.27400 1.000 23.57000 ? 222 ASP B OD1 1 
ATOM   3354 O OD2 . ASP B 1 178 ? 65.19800 58.83100 -23.66900 1.000 22.87000 ? 222 ASP B OD2 1 
ATOM   3355 N N   . THR B 1 179 ? 64.82800 55.24900 -20.43700 1.000 22.41000 ? 223 THR B N   1 
ATOM   3356 C CA  . THR B 1 179 ? 63.77100 54.28100 -20.19900 1.000 21.36000 ? 223 THR B CA  1 
ATOM   3357 C C   . THR B 1 179 ? 62.38300 54.83700 -20.46800 1.000 18.72000 ? 223 THR B C   1 
ATOM   3358 O O   . THR B 1 179 ? 61.41500 54.06700 -20.47100 1.000 20.54000 ? 223 THR B O   1 
ATOM   3359 C CB  . THR B 1 179 ? 63.83600 53.76600 -18.75500 1.000 24.91000 ? 223 THR B CB  1 
ATOM   3360 O OG1 . THR B 1 179 ? 63.82300 54.87900 -17.85200 1.000 26.20000 ? 223 THR B OG1 1 
ATOM   3361 C CG2 . THR B 1 179 ? 65.10600 52.96200 -18.54000 1.000 23.49000 ? 223 THR B CG2 1 
ATOM   3362 N N   . ILE B 1 180 ? 62.25400 56.14200 -20.68700 1.000 22.04000 ? 224 ILE B N   1 
ATOM   3363 C CA  . ILE B 1 180 ? 60.95700 56.72100 -21.02200 1.000 24.04000 ? 224 ILE B CA  1 
ATOM   3364 C C   . ILE B 1 180 ? 60.69900 56.62700 -22.51900 1.000 23.33000 ? 224 ILE B C   1 
ATOM   3365 O O   . ILE B 1 180 ? 59.62100 56.20800 -22.95500 1.000 21.24000 ? 224 ILE B O   1 
ATOM   3366 C CB  . ILE B 1 180 ? 60.89000 58.17700 -20.52500 1.000 22.65000 ? 224 ILE B CB  1 
ATOM   3367 C CG1 . ILE B 1 180 ? 61.12700 58.21400 -19.01100 1.000 22.66000 ? 224 ILE B CG1 1 
ATOM   3368 C CG2 . ILE B 1 180 ? 59.55400 58.80000 -20.88600 1.000 24.83000 ? 224 ILE B CG2 1 
ATOM   3369 C CD1 . ILE B 1 180 ? 61.44400 59.58800 -18.48200 1.000 23.32000 ? 224 ILE B CD1 1 
ATOM   3370 N N   . ALA B 1 181 ? 61.69300 57.00800 -23.32600 1.000 23.31000 ? 225 ALA B N   1 
ATOM   3371 C CA  . ALA B 1 181 ? 61.69100 56.80000 -24.77200 1.000 20.98000 ? 225 ALA B CA  1 
ATOM   3372 C C   . ALA B 1 181 ? 62.91500 55.94900 -25.09100 1.000 19.96000 ? 225 ALA B C   1 
ATOM   3373 O O   . ALA B 1 181 ? 63.93700 56.46800 -25.56600 1.000 21.11000 ? 225 ALA B O   1 
ATOM   3374 C CB  . ALA B 1 181 ? 61.70900 58.12400 -25.53100 1.000 19.34000 ? 225 ALA B CB  1 
ATOM   3375 N N   . PRO B 1 182 ? 62.85500 54.64400 -24.82400 1.000 19.88000 ? 226 PRO B N   1 
ATOM   3376 C CA  . PRO B 1 182 ? 64.04300 53.80100 -25.00700 1.000 21.80000 ? 226 PRO B CA  1 
ATOM   3377 C C   . PRO B 1 182 ? 64.49200 53.79200 -26.45900 1.000 23.71000 ? 226 PRO B C   1 
ATOM   3378 O O   . PRO B 1 182 ? 63.67800 53.69800 -27.38000 1.000 24.95000 ? 226 PRO B O   1 
ATOM   3379 C CB  . PRO B 1 182 ? 63.56900 52.41200 -24.55600 1.000 20.58000 ? 226 PRO B CB  1 
ATOM   3380 C CG  . PRO B 1 182 ? 62.32800 52.65800 -23.75600 1.000 22.59000 ? 226 PRO B CG  1 
ATOM   3381 C CD  . PRO B 1 182 ? 61.69500 53.87100 -24.35200 1.000 19.90000 ? 226 PRO B CD  1 
ATOM   3382 N N   . VAL B 1 183 ? 65.80800 53.90100 -26.65700 1.000 24.06000 ? 227 VAL B N   1 
ATOM   3383 C CA  . VAL B 1 183 ? 66.35400 53.95600 -28.00600 1.000 22.98000 ? 227 VAL B CA  1 
ATOM   3384 C C   . VAL B 1 183 ? 66.09000 52.66700 -28.76700 1.000 25.27000 ? 227 VAL B C   1 
ATOM   3385 O O   . VAL B 1 183 ? 66.05000 52.67600 -30.00100 1.000 24.80000 ? 227 VAL B O   1 
ATOM   3386 C CB  . VAL B 1 183 ? 67.86300 54.27000 -27.96600 1.000 21.11000 ? 227 VAL B CB  1 
ATOM   3387 C CG1 . VAL B 1 183 ? 68.10100 55.64400 -27.36900 1.000 22.35000 ? 227 VAL B CG1 1 
ATOM   3388 C CG2 . VAL B 1 183 ? 68.61200 53.20400 -27.18300 1.000 26.16000 ? 227 VAL B CG2 1 
ATOM   3389 N N   . SER B 1 184 ? 65.89500 51.55300 -28.05900 1.000 24.86000 ? 228 SER B N   1 
ATOM   3390 C CA  . SER B 1 184 ? 65.62800 50.28800 -28.73400 1.000 25.55000 ? 228 SER B CA  1 
ATOM   3391 C C   . SER B 1 184 ? 64.26100 50.28400 -29.40500 1.000 23.53000 ? 228 SER B C   1 
ATOM   3392 O O   . SER B 1 184 ? 64.08300 49.62900 -30.43800 1.000 27.54000 ? 228 SER B O   1 
ATOM   3393 C CB  . SER B 1 184 ? 65.73500 49.13000 -27.74100 1.000 28.46000 ? 228 SER B CB  1 
ATOM   3394 O OG  . SER B 1 184 ? 64.75800 49.23900 -26.71900 1.000 30.74000 ? 228 SER B OG  1 
ATOM   3395 N N   . THR B 1 185 ? 63.29100 51.00300 -28.84300 1.000 24.07000 ? 229 THR B N   1 
ATOM   3396 C CA  . THR B 1 185 ? 61.94300 51.05100 -29.39100 1.000 23.52000 ? 229 THR B CA  1 
ATOM   3397 C C   . THR B 1 185 ? 61.57200 52.40600 -29.97500 1.000 21.40000 ? 229 THR B C   1 
ATOM   3398 O O   . THR B 1 185 ? 60.50100 52.52600 -30.58000 1.000 20.80000 ? 229 THR B O   1 
ATOM   3399 C CB  . THR B 1 185 ? 60.91400 50.67600 -28.31400 1.000 24.01000 ? 229 THR B CB  1 
ATOM   3400 O OG1 . THR B 1 185 ? 61.09400 51.51800 -27.16800 1.000 24.00000 ? 229 THR B OG1 1 
ATOM   3401 C CG2 . THR B 1 185 ? 61.07300 49.22100 -27.90500 1.000 25.78000 ? 229 THR B CG2 1 
ATOM   3402 N N   . HIS B 1 186 ? 62.41700 53.42200 -29.81400 1.000 22.55000 ? 230 HIS B N   1 
ATOM   3403 C CA  . HIS B 1 186 ? 62.09800 54.75000 -30.31900 1.000 21.65000 ? 230 HIS B CA  1 
ATOM   3404 C C   . HIS B 1 186 ? 63.18400 55.27200 -31.24800 1.000 21.75000 ? 230 HIS B C   1 
ATOM   3405 O O   . HIS B 1 186 ? 63.03400 55.21200 -32.47200 1.000 26.09000 ? 230 HIS B O   1 
ATOM   3406 C CB  . HIS B 1 186 ? 61.87700 55.72200 -29.15800 1.000 22.48000 ? 230 HIS B CB  1 
ATOM   3407 C CG  . HIS B 1 186 ? 60.55600 55.55200 -28.47700 1.000 19.68000 ? 230 HIS B CG  1 
ATOM   3408 N ND1 . HIS B 1 186 ? 59.45700 56.32500 -28.78300 1.000 19.84000 ? 230 HIS B ND1 1 
ATOM   3409 C CD2 . HIS B 1 186 ? 60.15200 54.68800 -27.51600 1.000 20.65000 ? 230 HIS B CD2 1 
ATOM   3410 C CE1 . HIS B 1 186 ? 58.43500 55.94800 -28.03600 1.000 20.07000 ? 230 HIS B CE1 1 
ATOM   3411 N NE2 . HIS B 1 186 ? 58.83000 54.95600 -27.25800 1.000 19.02000 ? 230 HIS B NE2 1 
ATOM   3412 N N   . ALA B 1 187 ? 64.28400 55.76700 -30.67600 1.000 22.61000 ? 231 ALA B N   1 
ATOM   3413 C CA  . ALA B 1 187 ? 65.26800 56.50900 -31.46000 1.000 23.02000 ? 231 ALA B CA  1 
ATOM   3414 C C   . ALA B 1 187 ? 65.83100 55.66900 -32.60100 1.000 24.64000 ? 231 ALA B C   1 
ATOM   3415 O O   . ALA B 1 187 ? 65.92100 56.13500 -33.74200 1.000 23.93000 ? 231 ALA B O   1 
ATOM   3416 C CB  . ALA B 1 187 ? 66.39200 57.00600 -30.55200 1.000 21.13000 ? 231 ALA B CB  1 
ATOM   3417 N N   . LYS B 1 188 ? 66.21200 54.42800 -32.31500 1.000 25.20000 ? 232 LYS B N   1 
ATOM   3418 C CA  . LYS B 1 188 ? 66.82200 53.58400 -33.33600 1.000 25.29000 ? 232 LYS B CA  1 
ATOM   3419 C C   . LYS B 1 188 ? 65.80300 53.10800 -34.37100 1.000 26.95000 ? 232 LYS B C   1 
ATOM   3420 O O   . LYS B 1 188 ? 66.12300 53.09700 -35.56600 1.000 29.11000 ? 232 LYS B O   1 
ATOM   3421 C CB  . LYS B 1 188 ? 67.54100 52.39500 -32.69500 1.000 24.24000 ? 232 LYS B CB  1 
ATOM   3422 C CG  . LYS B 1 188 ? 68.84200 52.76600 -32.00600 1.000 23.76000 ? 232 LYS B CG  1 
ATOM   3423 C CD  . LYS B 1 188 ? 69.43700 51.58000 -31.27100 1.000 25.55000 ? 232 LYS B CD  1 
ATOM   3424 C CE  . LYS B 1 188 ? 70.80900 51.91600 -30.71900 1.000 28.88000 ? 232 LYS B CE  1 
ATOM   3425 N NZ  . LYS B 1 188 ? 71.33200 50.84700 -29.82300 1.000 34.27000 ? 232 LYS B NZ  1 
ATOM   3426 N N   . PRO B 1 189 ? 64.58700 52.69300 -33.98000 1.000 25.41000 ? 233 PRO B N   1 
ATOM   3427 C CA  . PRO B 1 189 ? 63.57800 52.39400 -35.01300 1.000 25.89000 ? 233 PRO B CA  1 
ATOM   3428 C C   . PRO B 1 189 ? 63.27100 53.57100 -35.92200 1.000 26.71000 ? 233 PRO B C   1 
ATOM   3429 O O   . PRO B 1 189 ? 63.02900 53.37200 -37.11900 1.000 28.51000 ? 233 PRO B O   1 
ATOM   3430 C CB  . PRO B 1 189 ? 62.35500 51.97700 -34.18700 1.000 26.15000 ? 233 PRO B CB  1 
ATOM   3431 C CG  . PRO B 1 189 ? 62.93400 51.38200 -32.97400 1.000 23.06000 ? 233 PRO B CG  1 
ATOM   3432 C CD  . PRO B 1 189 ? 64.14100 52.22100 -32.65500 1.000 24.41000 ? 233 PRO B CD  1 
ATOM   3433 N N   . PHE B 1 190 ? 63.26800 54.79500 -35.38800 1.000 25.22000 ? 234 PHE B N   1 
ATOM   3434 C CA  . PHE B 1 190 ? 63.03400 55.96200 -36.23400 1.000 24.21000 ? 234 PHE B CA  1 
ATOM   3435 C C   . PHE B 1 190 ? 64.14900 56.12500 -37.25900 1.000 25.01000 ? 234 PHE B C   1 
ATOM   3436 O O   . PHE B 1 190 ? 63.88600 56.40100 -38.43500 1.000 26.88000 ? 234 PHE B O   1 
ATOM   3437 C CB  . PHE B 1 190 ? 62.91500 57.22700 -35.38200 1.000 23.80000 ? 234 PHE B CB  1 
ATOM   3438 C CG  . PHE B 1 190 ? 61.82700 57.17100 -34.34700 1.000 22.47000 ? 234 PHE B CG  1 
ATOM   3439 C CD1 . PHE B 1 190 ? 60.72600 56.34700 -34.51400 1.000 22.21000 ? 234 PHE B CD1 1 
ATOM   3440 C CD2 . PHE B 1 190 ? 61.91000 57.94800 -33.20300 1.000 22.93000 ? 234 PHE B CD2 1 
ATOM   3441 C CE1 . PHE B 1 190 ? 59.73200 56.29700 -33.55900 1.000 22.04000 ? 234 PHE B CE1 1 
ATOM   3442 C CE2 . PHE B 1 190 ? 60.91800 57.90100 -32.24400 1.000 19.67000 ? 234 PHE B CE2 1 
ATOM   3443 C CZ  . PHE B 1 190 ? 59.82800 57.07400 -32.42300 1.000 20.60000 ? 234 PHE B CZ  1 
ATOM   3444 N N   . TYR B 1 191 ? 65.40100 55.95000 -36.83100 1.000 22.77000 ? 235 TYR B N   1 
ATOM   3445 C CA  . TYR B 1 191 ? 66.53200 56.17000 -37.72600 1.000 24.76000 ? 235 TYR B CA  1 
ATOM   3446 C C   . TYR B 1 191 ? 66.55800 55.14300 -38.85000 1.000 27.00000 ? 235 TYR B C   1 
ATOM   3447 O O   . TYR B 1 191 ? 66.77300 55.48900 -40.01800 1.000 25.90000 ? 235 TYR B O   1 
ATOM   3448 C CB  . TYR B 1 191 ? 67.84100 56.12900 -36.93600 1.000 21.97000 ? 235 TYR B CB  1 
ATOM   3449 C CG  . TYR B 1 191 ? 69.06900 56.14900 -37.81500 1.000 23.15000 ? 235 TYR B CG  1 
ATOM   3450 C CD1 . TYR B 1 191 ? 69.58500 57.34700 -38.28700 1.000 21.72000 ? 235 TYR B CD1 1 
ATOM   3451 C CD2 . TYR B 1 191 ? 69.71000 54.97000 -38.17800 1.000 25.50000 ? 235 TYR B CD2 1 
ATOM   3452 C CE1 . TYR B 1 191 ? 70.70200 57.37200 -39.09300 1.000 22.52000 ? 235 TYR B CE1 1 
ATOM   3453 C CE2 . TYR B 1 191 ? 70.82600 54.98600 -38.98600 1.000 23.34000 ? 235 TYR B CE2 1 
ATOM   3454 C CZ  . TYR B 1 191 ? 71.31800 56.19000 -39.43900 1.000 22.01000 ? 235 TYR B CZ  1 
ATOM   3455 O OH  . TYR B 1 191 ? 72.43100 56.21100 -40.24300 1.000 23.55000 ? 235 TYR B OH  1 
ATOM   3456 N N   . GLU B 1 192 ? 66.35000 53.86800 -38.51400 1.000 28.75000 ? 236 GLU B N   1 
ATOM   3457 C CA  . GLU B 1 192 ? 66.41000 52.81600 -39.52200 1.000 28.39000 ? 236 GLU B CA  1 
ATOM   3458 C C   . GLU B 1 192 ? 65.25500 52.91100 -40.51100 1.000 29.74000 ? 236 GLU B C   1 
ATOM   3459 O O   . GLU B 1 192 ? 65.39500 52.48800 -41.66300 1.000 30.70000 ? 236 GLU B O   1 
ATOM   3460 C CB  . GLU B 1 192 ? 66.42700 51.44600 -38.84400 1.000 28.33000 ? 236 GLU B CB  1 
ATOM   3461 C CG  . GLU B 1 192 ? 67.59200 51.23900 -37.88000 1.000 29.99000 ? 236 GLU B CG  1 
ATOM   3462 C CD  . GLU B 1 192 ? 68.94500 51.26300 -38.57000 1.000 34.13000 ? 236 GLU B CD  1 
ATOM   3463 O OE1 . GLU B 1 192 ? 69.01300 50.94000 -39.77400 1.000 38.35000 ? 236 GLU B OE1 1 
ATOM   3464 O OE2 . GLU B 1 192 ? 69.94500 51.60800 -37.90500 1.000 37.57000 ? 236 GLU B OE2 1 
ATOM   3465 N N   . SER B 1 193 ? 64.11400 53.46300 -40.08900 1.000 27.91000 ? 237 SER B N   1 
ATOM   3466 C CA  . SER B 1 193 ? 62.97600 53.60800 -40.98800 1.000 27.38000 ? 237 SER B CA  1 
ATOM   3467 C C   . SER B 1 193 ? 63.12200 54.79100 -41.93300 1.000 25.90000 ? 237 SER B C   1 
ATOM   3468 O O   . SER B 1 193 ? 62.44000 54.83000 -42.96200 1.000 25.87000 ? 237 SER B O   1 
ATOM   3469 C CB  . SER B 1 193 ? 61.68100 53.76000 -40.19100 1.000 25.24000 ? 237 SER B CB  1 
ATOM   3470 O OG  . SER B 1 193 ? 61.61600 55.03800 -39.58300 1.000 27.68000 ? 237 SER B OG  1 
ATOM   3471 N N   . LEU B 1 194 ? 63.97300 55.75700 -41.60000 1.000 26.62000 ? 238 LEU B N   1 
ATOM   3472 C CA  . LEU B 1 194 ? 64.24900 56.84700 -42.51800 1.000 25.82000 ? 238 LEU B CA  1 
ATOM   3473 C C   . LEU B 1 194 ? 64.87800 56.29300 -43.79500 1.000 26.32000 ? 238 LEU B C   1 
ATOM   3474 O O   . LEU B 1 194 ? 65.59400 55.28700 -43.75500 1.000 26.73000 ? 238 LEU B O   1 
ATOM   3475 C CB  . LEU B 1 194 ? 65.18100 57.87100 -41.87300 1.000 24.73000 ? 238 LEU B CB  1 
ATOM   3476 C CG  . LEU B 1 194 ? 64.62800 58.67300 -40.69600 1.000 22.92000 ? 238 LEU B CG  1 
ATOM   3477 C CD1 . LEU B 1 194 ? 65.74000 59.46800 -40.03400 1.000 24.13000 ? 238 LEU B CD1 1 
ATOM   3478 C CD2 . LEU B 1 194 ? 63.50800 59.59400 -41.15300 1.000 23.16000 ? 238 LEU B CD2 1 
ATOM   3479 N N   . PRO B 1 195 ? 64.61600 56.92000 -44.94100 1.000 27.24000 ? 239 PRO B N   1 
ATOM   3480 C CA  . PRO B 1 195 ? 65.16600 56.41100 -46.20300 1.000 25.66000 ? 239 PRO B CA  1 
ATOM   3481 C C   . PRO B 1 195 ? 66.68500 56.32500 -46.16300 1.000 22.30000 ? 239 PRO B C   1 
ATOM   3482 O O   . PRO B 1 195 ? 67.36600 57.22900 -45.67800 1.000 24.89000 ? 239 PRO B O   1 
ATOM   3483 C CB  . PRO B 1 195 ? 64.68400 57.43600 -47.23500 1.000 25.12000 ? 239 PRO B CB  1 
ATOM   3484 C CG  . PRO B 1 195 ? 63.45400 58.02600 -46.62600 1.000 23.79000 ? 239 PRO B CG  1 
ATOM   3485 C CD  . PRO B 1 195 ? 63.72600 58.07500 -45.15200 1.000 24.84000 ? 239 PRO B CD  1 
ATOM   3486 N N   . SER B 1 196 ? 67.20900 55.21000 -46.68200 1.000 22.71000 ? 240 SER B N   1 
ATOM   3487 C CA  . SER B 1 196 ? 68.64600 54.96400 -46.65900 1.000 22.43000 ? 240 SER B CA  1 
ATOM   3488 C C   . SER B 1 196 ? 69.42500 55.97800 -47.48500 1.000 23.29000 ? 240 SER B C   1 
ATOM   3489 O O   . SER B 1 196 ? 70.63200 56.13900 -47.27000 1.000 23.53000 ? 240 SER B O   1 
ATOM   3490 C CB  . SER B 1 196 ? 68.94200 53.54900 -47.15800 1.000 26.90000 ? 240 SER B CB  1 
ATOM   3491 O OG  . SER B 1 196 ? 68.43100 53.35200 -48.46600 1.000 26.77000 ? 240 SER B OG  1 
ATOM   3492 N N   . SER B 1 197 ? 68.77200 56.65600 -48.42400 1.000 22.75000 ? 241 SER B N   1 
ATOM   3493 C CA  . SER B 1 197 ? 69.41500 57.69600 -49.21300 1.000 22.45000 ? 241 SER B CA  1 
ATOM   3494 C C   . SER B 1 197 ? 69.34100 59.06300 -48.55600 1.000 22.91000 ? 241 SER B C   1 
ATOM   3495 O O   . SER B 1 197 ? 70.02800 59.98800 -49.00200 1.000 23.40000 ? 241 SER B O   1 
ATOM   3496 C CB  . SER B 1 197 ? 68.77800 57.77300 -50.60100 1.000 21.70000 ? 241 SER B CB  1 
ATOM   3497 O OG  . SER B 1 197 ? 67.42100 58.17100 -50.50500 1.000 20.32000 ? 241 SER B OG  1 
ATOM   3498 N N   . LEU B 1 198 ? 68.52900 59.21000 -47.52000 1.000 23.05000 ? 242 LEU B N   1 
ATOM   3499 C CA  . LEU B 1 198 ? 68.39100 60.49600 -46.85200 1.000 21.83000 ? 242 LEU B CA  1 
ATOM   3500 C C   . LEU B 1 198 ? 69.65600 60.81500 -46.06100 1.000 23.95000 ? 242 LEU B C   1 
ATOM   3501 O O   . LEU B 1 198 ? 70.19000 59.93700 -45.37200 1.000 25.30000 ? 242 LEU B O   1 
ATOM   3502 C CB  . LEU B 1 198 ? 67.17800 60.47800 -45.92400 1.000 23.87000 ? 242 LEU B CB  1 
ATOM   3503 C CG  . LEU B 1 198 ? 66.96800 61.72000 -45.05300 1.000 24.72000 ? 242 LEU B CG  1 
ATOM   3504 C CD1 . LEU B 1 198 ? 66.48900 62.88000 -45.90200 1.000 24.12000 ? 242 LEU B CD1 1 
ATOM   3505 C CD2 . LEU B 1 198 ? 65.99800 61.44200 -43.90900 1.000 24.17000 ? 242 LEU B CD2 1 
ATOM   3506 N N   . PRO B 1 199 ? 70.17700 62.04200 -46.14400 1.000 24.10000 ? 243 PRO B N   1 
ATOM   3507 C CA  . PRO B 1 199 ? 71.27000 62.43000 -45.24500 1.000 25.18000 ? 243 PRO B CA  1 
ATOM   3508 C C   . PRO B 1 199 ? 70.80500 62.41400 -43.79800 1.000 23.79000 ? 243 PRO B C   1 
ATOM   3509 O O   . PRO B 1 199 ? 70.06600 63.30500 -43.36800 1.000 23.88000 ? 243 PRO B O   1 
ATOM   3510 C CB  . PRO B 1 199 ? 71.63500 63.84600 -45.71100 1.000 24.99000 ? 243 PRO B CB  1 
ATOM   3511 C CG  . PRO B 1 199 ? 71.12000 63.94000 -47.11000 1.000 25.17000 ? 243 PRO B CG  1 
ATOM   3512 C CD  . PRO B 1 199 ? 69.88500 63.08600 -47.14100 1.000 23.23000 ? 243 PRO B CD  1 
ATOM   3513 N N   . LYS B 1 200 ? 71.21900 61.40100 -43.03900 1.000 25.05000 ? 244 LYS B N   1 
ATOM   3514 C CA  . LYS B 1 200 ? 70.72900 61.20700 -41.68400 1.000 24.68000 ? 244 LYS B CA  1 
ATOM   3515 C C   . LYS B 1 200 ? 71.87800 60.79100 -40.77800 1.000 24.21000 ? 244 LYS B C   1 
ATOM   3516 O O   . LYS B 1 200 ? 72.97700 60.46700 -41.23400 1.000 24.07000 ? 244 LYS B O   1 
ATOM   3517 C CB  . LYS B 1 200 ? 69.60400 60.16500 -41.64200 1.000 23.35000 ? 244 LYS B CB  1 
ATOM   3518 C CG  . LYS B 1 200 ? 69.99100 58.81200 -42.21400 1.000 23.84000 ? 244 LYS B CG  1 
ATOM   3519 C CD  . LYS B 1 200 ? 68.82500 57.84000 -42.16500 1.000 23.20000 ? 244 LYS B CD  1 
ATOM   3520 C CE  . LYS B 1 200 ? 69.24000 56.45400 -42.63300 1.000 22.62000 ? 244 LYS B CE  1 
ATOM   3521 N NZ  . LYS B 1 200 ? 68.12000 55.47700 -42.55300 1.000 23.57000 ? 244 LYS B NZ  1 
ATOM   3522 N N   . ALA B 1 201 ? 71.60500 60.80000 -39.47500 1.000 23.61000 ? 245 ALA B N   1 
ATOM   3523 C CA  . ALA B 1 201 ? 72.59900 60.42900 -38.48100 1.000 23.08000 ? 245 ALA B CA  1 
ATOM   3524 C C   . ALA B 1 201 ? 71.88900 60.08000 -37.18200 1.000 22.79000 ? 245 ALA B C   1 
ATOM   3525 O O   . ALA B 1 201 ? 70.81300 60.60500 -36.88600 1.000 21.95000 ? 245 ALA B O   1 
ATOM   3526 C CB  . ALA B 1 201 ? 73.61500 61.55300 -38.25100 1.000 22.55000 ? 245 ALA B CB  1 
ATOM   3527 N N   . TYR B 1 202 ? 72.50100 59.17700 -36.41800 1.000 24.05000 ? 246 TYR B N   1 
ATOM   3528 C CA  . TYR B 1 202 ? 72.01600 58.80000 -35.09500 1.000 25.06000 ? 246 TYR B CA  1 
ATOM   3529 C C   . TYR B 1 202 ? 73.19100 58.80200 -34.13400 1.000 25.33000 ? 246 TYR B C   1 
ATOM   3530 O O   . TYR B 1 202 ? 74.18000 58.09900 -34.36200 1.000 25.85000 ? 246 TYR B O   1 
ATOM   3531 C CB  . TYR B 1 202 ? 71.34200 57.42500 -35.10800 1.000 26.10000 ? 246 TYR B CB  1 
ATOM   3532 C CG  . TYR B 1 202 ? 71.07700 56.87400 -33.72300 1.000 26.35000 ? 246 TYR B CG  1 
ATOM   3533 C CD1 . TYR B 1 202 ? 70.08400 57.41700 -32.91900 1.000 26.29000 ? 246 TYR B CD1 1 
ATOM   3534 C CD2 . TYR B 1 202 ? 71.82200 55.81500 -33.21900 1.000 27.41000 ? 246 TYR B CD2 1 
ATOM   3535 C CE1 . TYR B 1 202 ? 69.83900 56.92200 -31.65300 1.000 26.74000 ? 246 TYR B CE1 1 
ATOM   3536 C CE2 . TYR B 1 202 ? 71.58300 55.31100 -31.95200 1.000 29.25000 ? 246 TYR B CE2 1 
ATOM   3537 C CZ  . TYR B 1 202 ? 70.58900 55.87000 -31.17400 1.000 27.80000 ? 246 TYR B CZ  1 
ATOM   3538 O OH  . TYR B 1 202 ? 70.34000 55.37900 -29.91300 1.000 30.50000 ? 246 TYR B OH  1 
ATOM   3539 N N   . MET B 1 203 ? 73.08500 59.58700 -33.06600 1.000 25.51000 ? 247 MET B N   1 
ATOM   3540 C CA  . MET B 1 203 ? 74.11600 59.66600 -32.04200 1.000 26.73000 ? 247 MET B CA  1 
ATOM   3541 C C   . MET B 1 203 ? 73.53600 59.21400 -30.71100 1.000 24.73000 ? 247 MET B C   1 
ATOM   3542 O O   . MET B 1 203 ? 72.50200 59.72900 -30.27400 1.000 23.94000 ? 247 MET B O   1 
ATOM   3543 C CB  . MET B 1 203 ? 74.67100 61.08500 -31.92200 1.000 23.53000 ? 247 MET B CB  1 
ATOM   3544 C CG  . MET B 1 203 ? 75.79800 61.21200 -30.91300 1.000 23.19000 ? 247 MET B CG  1 
ATOM   3545 S SD  . MET B 1 203 ? 76.45300 62.88500 -30.80500 1.000 25.71000 ? 247 MET B SD  1 
ATOM   3546 C CE  . MET B 1 203 ? 75.03000 63.76900 -30.18300 1.000 21.65000 ? 247 MET B CE  1 
ATOM   3547 N N   . GLU B 1 204 ? 74.19800 58.25400 -30.07400 1.000 26.51000 ? 248 GLU B N   1 
ATOM   3548 C CA  . GLU B 1 204 ? 73.79400 57.74900 -28.76900 1.000 25.77000 ? 248 GLU B CA  1 
ATOM   3549 C C   . GLU B 1 204 ? 74.79700 58.21300 -27.72400 1.000 25.02000 ? 248 GLU B C   1 
ATOM   3550 O O   . GLU B 1 204 ? 76.00600 58.01200 -27.88400 1.000 26.77000 ? 248 GLU B O   1 
ATOM   3551 C CB  . GLU B 1 204 ? 73.69200 56.22300 -28.77700 1.000 26.70000 ? 248 GLU B CB  1 
ATOM   3552 C CG  . GLU B 1 204 ? 73.19900 55.62300 -27.47200 1.000 26.33000 ? 248 GLU B CG  1 
ATOM   3553 C CD  . GLU B 1 204 ? 72.76600 54.18200 -27.63200 1.000 28.52000 ? 248 GLU B CD  1 
ATOM   3554 O OE1 . GLU B 1 204 ? 72.42300 53.79500 -28.76800 1.000 31.13000 ? 248 GLU B OE1 1 
ATOM   3555 O OE2 . GLU B 1 204 ? 72.77100 53.43500 -26.63200 1.000 30.35000 ? 248 GLU B OE2 1 
ATOM   3556 N N   . LEU B 1 205 ? 74.29300 58.83200 -26.66100 1.000 26.01000 ? 249 LEU B N   1 
ATOM   3557 C CA  . LEU B 1 205 ? 75.13800 59.41700 -25.63000 1.000 24.37000 ? 249 LEU B CA  1 
ATOM   3558 C C   . LEU B 1 205 ? 75.39300 58.40400 -24.52200 1.000 24.83000 ? 249 LEU B C   1 
ATOM   3559 O O   . LEU B 1 205 ? 74.45500 57.78100 -24.01400 1.000 24.17000 ? 249 LEU B O   1 
ATOM   3560 C CB  . LEU B 1 205 ? 74.48400 60.67500 -25.05900 1.000 25.33000 ? 249 LEU B CB  1 
ATOM   3561 C CG  . LEU B 1 205 ? 74.25300 61.80400 -26.06300 1.000 23.37000 ? 249 LEU B CG  1 
ATOM   3562 C CD1 . LEU B 1 205 ? 73.33800 62.86200 -25.47900 1.000 22.59000 ? 249 LEU B CD1 1 
ATOM   3563 C CD2 . LEU B 1 205 ? 75.57900 62.41200 -26.47900 1.000 25.76000 ? 249 LEU B CD2 1 
ATOM   3564 N N   . CYS B 1 206 ? 76.66300 58.25000 -24.14900 1.000 27.44000 ? 250 CYS B N   1 
ATOM   3565 C CA  . CYS B 1 206 ? 77.03500 57.29400 -23.11400 1.000 28.10000 ? 250 CYS B CA  1 
ATOM   3566 C C   . CYS B 1 206 ? 76.43300 57.68300 -21.77000 1.000 28.15000 ? 250 CYS B C   1 
ATOM   3567 O O   . CYS B 1 206 ? 76.60300 58.81400 -21.30400 1.000 28.44000 ? 250 CYS B O   1 
ATOM   3568 C CB  . CYS B 1 206 ? 78.55600 57.21100 -22.99000 1.000 27.98000 ? 250 CYS B CB  1 
ATOM   3569 S SG  . CYS B 1 206 ? 79.42900 56.50300 -24.40100 1.000 35.48000 ? 250 CYS B SG  1 
ATOM   3570 N N   . GLY B 1 207 ? 75.73300 56.73500 -21.14900 1.000 26.32000 ? 251 GLY B N   1 
ATOM   3571 C CA  . GLY B 1 207 ? 75.22400 56.92000 -19.80200 1.000 27.05000 ? 251 GLY B CA  1 
ATOM   3572 C C   . GLY B 1 207 ? 74.28800 58.09000 -19.62700 1.000 29.74000 ? 251 GLY B C   1 
ATOM   3573 O O   . GLY B 1 207 ? 74.14700 58.59800 -18.51100 1.000 31.76000 ? 251 GLY B O   1 
ATOM   3574 N N   . ALA B 1 208 ? 73.64600 58.54100 -20.69700 1.000 28.27000 ? 252 ALA B N   1 
ATOM   3575 C CA  . ALA B 1 208 ? 72.72400 59.65900 -20.61300 1.000 24.49000 ? 252 ALA B CA  1 
ATOM   3576 C C   . ALA B 1 208 ? 71.30500 59.15900 -20.36800 1.000 24.17000 ? 252 ALA B C   1 
ATOM   3577 O O   . ALA B 1 208 ? 70.96400 58.00800 -20.65000 1.000 25.98000 ? 252 ALA B O   1 
ATOM   3578 C CB  . ALA B 1 208 ? 72.77500 60.50400 -21.88600 1.000 25.99000 ? 252 ALA B CB  1 
ATOM   3579 N N   . THR B 1 209 ? 70.48000 60.04600 -19.82900 1.000 27.07000 ? 253 THR B N   1 
ATOM   3580 C CA  . THR B 1 209 ? 69.09600 59.74900 -19.50500 1.000 25.88000 ? 253 THR B CA  1 
ATOM   3581 C C   . THR B 1 209 ? 68.17200 60.48000 -20.47400 1.000 23.72000 ? 253 THR B C   1 
ATOM   3582 O O   . THR B 1 209 ? 68.61200 61.23700 -21.34400 1.000 25.29000 ? 253 THR B O   1 
ATOM   3583 C CB  . THR B 1 209 ? 68.78500 60.13700 -18.05700 1.000 23.45000 ? 253 THR B CB  1 
ATOM   3584 O OG1 . THR B 1 209 ? 68.73700 61.56400 -17.94400 1.000 25.02000 ? 253 THR B OG1 1 
ATOM   3585 C CG2 . THR B 1 209 ? 69.85800 59.60000 -17.12000 1.000 25.39000 ? 253 THR B CG2 1 
ATOM   3586 N N   . HIS B 1 210 ? 66.87000 60.24700 -20.30300 1.000 23.73000 ? 254 HIS B N   1 
ATOM   3587 C CA  . HIS B 1 210 ? 65.85800 60.89000 -21.13500 1.000 22.00000 ? 254 HIS B CA  1 
ATOM   3588 C C   . HIS B 1 210 ? 65.90200 62.40900 -21.03900 1.000 23.92000 ? 254 HIS B C   1 
ATOM   3589 O O   . HIS B 1 210 ? 65.39700 63.09200 -21.93600 1.000 23.75000 ? 254 HIS B O   1 
ATOM   3590 C CB  . HIS B 1 210 ? 64.47400 60.38400 -20.73000 1.000 21.96000 ? 254 HIS B CB  1 
ATOM   3591 C CG  . HIS B 1 210 ? 63.36600 60.85100 -21.62100 1.000 23.45000 ? 254 HIS B CG  1 
ATOM   3592 N ND1 . HIS B 1 210 ? 63.16200 60.34100 -22.88500 1.000 23.44000 ? 254 HIS B ND1 1 
ATOM   3593 C CD2 . HIS B 1 210 ? 62.39200 61.77100 -21.42500 1.000 24.46000 ? 254 HIS B CD2 1 
ATOM   3594 C CE1 . HIS B 1 210 ? 62.11300 60.93100 -23.43100 1.000 22.52000 ? 254 HIS B CE1 1 
ATOM   3595 N NE2 . HIS B 1 210 ? 61.62800 61.80200 -22.56500 1.000 22.30000 ? 254 HIS B NE2 1 
ATOM   3596 N N   . PHE B 1 211 ? 66.49300 62.95300 -19.97700 1.000 25.20000 ? 255 PHE B N   1 
ATOM   3597 C CA  . PHE B 1 211 ? 66.49200 64.38900 -19.74000 1.000 24.05000 ? 255 PHE B CA  1 
ATOM   3598 C C   . PHE B 1 211 ? 67.85300 65.02700 -19.97900 1.000 22.51000 ? 255 PHE B C   1 
ATOM   3599 O O   . PHE B 1 211 ? 68.04500 66.19700 -19.63900 1.000 25.35000 ? 255 PHE B O   1 
ATOM   3600 C CB  . PHE B 1 211 ? 66.00600 64.67800 -18.32000 1.000 24.21000 ? 255 PHE B CB  1 
ATOM   3601 C CG  . PHE B 1 211 ? 64.70300 64.01600 -17.99200 1.000 22.39000 ? 255 PHE B CG  1 
ATOM   3602 C CD1 . PHE B 1 211 ? 63.50800 64.56500 -18.42000 1.000 23.17000 ? 255 PHE B CD1 1 
ATOM   3603 C CD2 . PHE B 1 211 ? 64.67300 62.83300 -17.27300 1.000 22.71000 ? 255 PHE B CD2 1 
ATOM   3604 C CE1 . PHE B 1 211 ? 62.30600 63.95400 -18.13000 1.000 23.77000 ? 255 PHE B CE1 1 
ATOM   3605 C CE2 . PHE B 1 211 ? 63.47500 62.21700 -16.97900 1.000 21.07000 ? 255 PHE B CE2 1 
ATOM   3606 C CZ  . PHE B 1 211 ? 62.28900 62.78000 -17.40700 1.000 23.74000 ? 255 PHE B CZ  1 
ATOM   3607 N N   . ALA B 1 212 ? 68.79800 64.28600 -20.55500 1.000 23.48000 ? 256 ALA B N   1 
ATOM   3608 C CA  . ALA B 1 212 ? 70.08400 64.87800 -20.91400 1.000 23.09000 ? 256 ALA B CA  1 
ATOM   3609 C C   . ALA B 1 212 ? 69.96500 66.07000 -21.86100 1.000 24.68000 ? 256 ALA B C   1 
ATOM   3610 O O   . ALA B 1 212 ? 70.74400 67.02600 -21.69600 1.000 26.20000 ? 256 ALA B O   1 
ATOM   3611 C CB  . ALA B 1 212 ? 71.00200 63.80300 -21.51000 1.000 24.11000 ? 256 ALA B CB  1 
ATOM   3612 N N   . PRO B 1 213 ? 69.06000 66.09600 -22.85000 1.000 23.03000 ? 257 PRO B N   1 
ATOM   3613 C CA  . PRO B 1 213 ? 68.95900 67.29000 -23.70800 1.000 25.08000 ? 257 PRO B CA  1 
ATOM   3614 C C   . PRO B 1 213 ? 68.52200 68.55500 -22.98400 1.000 26.09000 ? 257 PRO B C   1 
ATOM   3615 O O   . PRO B 1 213 ? 68.63100 69.63900 -23.57000 1.000 25.95000 ? 257 PRO B O   1 
ATOM   3616 C CB  . PRO B 1 213 ? 67.92100 66.87900 -24.76200 1.000 23.06000 ? 257 PRO B CB  1 
ATOM   3617 C CG  . PRO B 1 213 ? 68.00100 65.40600 -24.80800 1.000 22.96000 ? 257 PRO B CG  1 
ATOM   3618 C CD  . PRO B 1 213 ? 68.25800 64.98400 -23.39500 1.000 20.96000 ? 257 PRO B CD  1 
ATOM   3619 N N   . ASN B 1 214 ? 68.03400 68.46400 -21.74800 1.000 26.61000 ? 258 ASN B N   1 
ATOM   3620 C CA  . ASN B 1 214 ? 67.47400 69.62400 -21.06700 1.000 26.21000 ? 258 ASN B CA  1 
ATOM   3621 C C   . ASN B 1 214 ? 68.50900 70.45000 -20.31800 1.000 25.15000 ? 258 ASN B C   1 
ATOM   3622 O O   . ASN B 1 214 ? 68.18600 71.55300 -19.86400 1.000 25.36000 ? 258 ASN B O   1 
ATOM   3623 C CB  . ASN B 1 214 ? 66.37500 69.18400 -20.09600 1.000 25.80000 ? 258 ASN B CB  1 
ATOM   3624 C CG  . ASN B 1 214 ? 65.21200 68.52400 -20.79900 1.000 23.25000 ? 258 ASN B CG  1 
ATOM   3625 O OD1 . ASN B 1 214 ? 64.79500 67.42600 -20.43400 1.000 24.56000 ? 258 ASN B OD1 1 
ATOM   3626 N ND2 . ASN B 1 214 ? 64.68400 69.18700 -21.81900 1.000 25.96000 ? 258 ASN B ND2 1 
ATOM   3627 N N   . ILE B 1 215 ? 69.72900 69.95200 -20.17900 1.000 26.32000 ? 259 ILE B N   1 
ATOM   3628 C CA  . ILE B 1 215 ? 70.80200 70.69000 -19.51900 1.000 27.82000 ? 259 ILE B CA  1 
ATOM   3629 C C   . ILE B 1 215 ? 71.91600 70.88700 -20.53500 1.000 27.17000 ? 259 ILE B C   1 
ATOM   3630 O O   . ILE B 1 215 ? 72.03800 70.11500 -21.50200 1.000 27.93000 ? 259 ILE B O   1 
ATOM   3631 C CB  . ILE B 1 215 ? 71.30500 69.96200 -18.25100 1.000 27.41000 ? 259 ILE B CB  1 
ATOM   3632 C CG1 . ILE B 1 215 ? 71.78800 68.55400 -18.60200 1.000 25.93000 ? 259 ILE B CG1 1 
ATOM   3633 C CG2 . ILE B 1 215 ? 70.21100 69.91700 -17.19700 1.000 30.64000 ? 259 ILE B CG2 1 
ATOM   3634 C CD1 . ILE B 1 215 ? 72.31700 67.78600 -17.41200 1.000 28.28000 ? 259 ILE B CD1 1 
ATOM   3635 N N   . PRO B 1 216 ? 72.73900 71.92000 -20.35700 1.000 28.45000 ? 260 PRO B N   1 
ATOM   3636 C CA  . PRO B 1 216 ? 73.84500 72.15900 -21.29200 1.000 27.32000 ? 260 PRO B CA  1 
ATOM   3637 C C   . PRO B 1 216 ? 74.71500 70.92500 -21.47600 1.000 29.59000 ? 260 PRO B C   1 
ATOM   3638 O O   . PRO B 1 216 ? 75.16500 70.30300 -20.51100 1.000 31.52000 ? 260 PRO B O   1 
ATOM   3639 C CB  . PRO B 1 216 ? 74.61200 73.30600 -20.63000 1.000 29.18000 ? 260 PRO B CB  1 
ATOM   3640 C CG  . PRO B 1 216 ? 73.54900 74.06400 -19.90900 1.000 24.05000 ? 260 PRO B CG  1 
ATOM   3641 C CD  . PRO B 1 216 ? 72.58600 73.02700 -19.39600 1.000 27.01000 ? 260 PRO B CD  1 
ATOM   3642 N N   . ASN B 1 217 ? 74.93000 70.56100 -22.73600 1.000 29.57000 ? 261 ASN B N   1 
ATOM   3643 C CA  . ASN B 1 217 ? 75.69000 69.36800 -23.09100 1.000 27.10000 ? 261 ASN B CA  1 
ATOM   3644 C C   . ASN B 1 217 ? 76.51700 69.71800 -24.31900 1.000 28.69000 ? 261 ASN B C   1 
ATOM   3645 O O   . ASN B 1 217 ? 75.95900 69.97400 -25.39100 1.000 32.34000 ? 261 ASN B O   1 
ATOM   3646 C CB  . ASN B 1 217 ? 74.76000 68.18200 -23.35500 1.000 26.34000 ? 261 ASN B CB  1 
ATOM   3647 C CG  . ASN B 1 217 ? 75.50700 66.87400 -23.54300 1.000 26.00000 ? 261 ASN B CG  1 
ATOM   3648 O OD1 . ASN B 1 217 ? 76.49500 66.80600 -24.27200 1.000 28.86000 ? 261 ASN B OD1 1 
ATOM   3649 N ND2 . ASN B 1 217 ? 75.03200 65.82400 -22.88500 1.000 25.56000 ? 261 ASN B ND2 1 
ATOM   3650 N N   . THR B 1 218 ? 77.84100 69.74400 -24.15900 1.000 30.01000 ? 262 THR B N   1 
ATOM   3651 C CA  . THR B 1 218 ? 78.71000 70.13800 -25.26300 1.000 31.03000 ? 262 THR B CA  1 
ATOM   3652 C C   . THR B 1 218 ? 78.62400 69.14700 -26.41600 1.000 30.46000 ? 262 THR B C   1 
ATOM   3653 O O   . THR B 1 218 ? 78.57600 69.54800 -27.58500 1.000 30.92000 ? 262 THR B O   1 
ATOM   3654 C CB  . THR B 1 218 ? 80.15200 70.27300 -24.77300 1.000 30.55000 ? 262 THR B CB  1 
ATOM   3655 O OG1 . THR B 1 218 ? 80.23800 71.35400 -23.83700 1.000 34.69000 ? 262 THR B OG1 1 
ATOM   3656 C CG2 . THR B 1 218 ? 81.08500 70.54900 -25.93700 1.000 33.31000 ? 262 THR B CG2 1 
ATOM   3657 N N   . THR B 1 219 ? 78.59500 67.84800 -26.10700 1.000 29.12000 ? 263 THR B N   1 
ATOM   3658 C CA  . THR B 1 219 ? 78.49200 66.83900 -27.15700 1.000 28.11000 ? 263 THR B CA  1 
ATOM   3659 C C   . THR B 1 219 ? 77.20400 67.00500 -27.95300 1.000 31.12000 ? 263 THR B C   1 
ATOM   3660 O O   . THR B 1 219 ? 77.19500 66.83900 -29.17900 1.000 33.93000 ? 263 THR B O   1 
ATOM   3661 C CB  . THR B 1 219 ? 78.57400 65.43900 -26.54900 1.000 28.55000 ? 263 THR B CB  1 
ATOM   3662 O OG1 . THR B 1 219 ? 79.81800 65.29500 -25.85300 1.000 32.37000 ? 263 THR B OG1 1 
ATOM   3663 C CG2 . THR B 1 219 ? 78.48500 64.37800 -27.63500 1.000 29.35000 ? 263 THR B CG2 1 
ATOM   3664 N N   . ILE B 1 220 ? 76.10700 67.34500 -27.27500 1.000 28.27000 ? 264 ILE B N   1 
ATOM   3665 C CA  . ILE B 1 220 ? 74.87100 67.66800 -27.97900 1.000 27.00000 ? 264 ILE B CA  1 
ATOM   3666 C C   . ILE B 1 220 ? 75.02500 68.97600 -28.74400 1.000 29.14000 ? 264 ILE B C   1 
ATOM   3667 O O   . ILE B 1 220 ? 74.65200 69.07500 -29.91800 1.000 30.68000 ? 264 ILE B O   1 
ATOM   3668 C CB  . ILE B 1 220 ? 73.69100 67.73000 -26.99300 1.000 24.13000 ? 264 ILE B CB  1 
ATOM   3669 C CG1 . ILE B 1 220 ? 73.32400 66.33300 -26.50300 1.000 22.94000 ? 264 ILE B CG1 1 
ATOM   3670 C CG2 . ILE B 1 220 ? 72.48700 68.39400 -27.63700 1.000 23.81000 ? 264 ILE B CG2 1 
ATOM   3671 C CD1 . ILE B 1 220 ? 72.12700 66.32300 -25.58900 1.000 23.01000 ? 264 ILE B CD1 1 
ATOM   3672 N N   . ALA B 1 221 ? 75.59400 69.99500 -28.09600 1.000 27.03000 ? 265 ALA B N   1 
ATOM   3673 C CA  . ALA B 1 221 ? 75.62500 71.32700 -28.69000 1.000 28.54000 ? 265 ALA B CA  1 
ATOM   3674 C C   . ALA B 1 221 ? 76.54100 71.38600 -29.90700 1.000 31.23000 ? 265 ALA B C   1 
ATOM   3675 O O   . ALA B 1 221 ? 76.25500 72.11000 -30.86700 1.000 31.06000 ? 265 ALA B O   1 
ATOM   3676 C CB  . ALA B 1 221 ? 76.05800 72.35700 -27.64900 1.000 28.91000 ? 265 ALA B CB  1 
ATOM   3677 N N   . LYS B 1 222 ? 77.64400 70.63700 -29.89200 1.000 30.16000 ? 266 LYS B N   1 
ATOM   3678 C CA  . LYS B 1 222 ? 78.62700 70.77800 -30.96300 1.000 30.40000 ? 266 LYS B CA  1 
ATOM   3679 C C   . LYS B 1 222 ? 78.11600 70.19600 -32.27700 1.000 31.71000 ? 266 LYS B C   1 
ATOM   3680 O O   . LYS B 1 222 ? 78.38900 70.74600 -33.35000 1.000 32.56000 ? 266 LYS B O   1 
ATOM   3681 C CB  . LYS B 1 222 ? 79.95000 70.12800 -30.55700 1.000 29.99000 ? 266 LYS B CB  1 
ATOM   3682 C CG  . LYS B 1 222 ? 79.86600 68.63700 -30.30000 1.000 30.42000 ? 266 LYS B CG  1 
ATOM   3683 C CD  . LYS B 1 222 ? 81.19900 68.08200 -29.83900 1.000 31.68000 ? 266 LYS B CD  1 
ATOM   3684 C CE  . LYS B 1 222 ? 82.27800 68.30100 -30.88300 1.000 30.36000 ? 266 LYS B CE  1 
ATOM   3685 N NZ  . LYS B 1 222 ? 83.57300 67.69300 -30.47200 1.000 32.02000 ? 266 LYS B NZ  1 
ATOM   3686 N N   . TYR B 1 223 ? 77.36500 69.09500 -32.21700 1.000 31.40000 ? 267 TYR B N   1 
ATOM   3687 C CA  . TYR B 1 223 ? 76.88200 68.44700 -33.43000 1.000 28.71000 ? 267 TYR B CA  1 
ATOM   3688 C C   . TYR B 1 223 ? 75.47100 68.86300 -33.81700 1.000 31.01000 ? 267 TYR B C   1 
ATOM   3689 O O   . TYR B 1 223 ? 75.06800 68.63200 -34.96200 1.000 32.29000 ? 267 TYR B O   1 
ATOM   3690 C CB  . TYR B 1 223 ? 76.96100 66.92500 -33.28100 1.000 27.13000 ? 267 TYR B CB  1 
ATOM   3691 C CG  . TYR B 1 223 ? 78.38200 66.45100 -33.10000 1.000 28.80000 ? 267 TYR B CG  1 
ATOM   3692 C CD1 . TYR B 1 223 ? 79.34300 66.70900 -34.06900 1.000 28.07000 ? 267 TYR B CD1 1 
ATOM   3693 C CD2 . TYR B 1 223 ? 78.77000 65.76600 -31.95800 1.000 27.12000 ? 267 TYR B CD2 1 
ATOM   3694 C CE1 . TYR B 1 223 ? 80.64700 66.29400 -33.91000 1.000 28.67000 ? 267 TYR B CE1 1 
ATOM   3695 C CE2 . TYR B 1 223 ? 80.07400 65.34400 -31.79000 1.000 28.83000 ? 267 TYR B CE2 1 
ATOM   3696 C CZ  . TYR B 1 223 ? 81.00700 65.61200 -32.77000 1.000 30.96000 ? 267 TYR B CZ  1 
ATOM   3697 O OH  . TYR B 1 223 ? 82.30800 65.19500 -32.61000 1.000 31.99000 ? 267 TYR B OH  1 
ATOM   3698 N N   . VAL B 1 224 ? 74.71600 69.46700 -32.90000 1.000 30.08000 ? 268 VAL B N   1 
ATOM   3699 C CA  . VAL B 1 224 ? 73.49100 70.15200 -33.30000 1.000 28.91000 ? 268 VAL B CA  1 
ATOM   3700 C C   . VAL B 1 224 ? 73.83100 71.37900 -34.13800 1.000 29.52000 ? 268 VAL B C   1 
ATOM   3701 O O   . VAL B 1 224 ? 73.15500 71.68000 -35.12900 1.000 29.90000 ? 268 VAL B O   1 
ATOM   3702 C CB  . VAL B 1 224 ? 72.64800 70.51300 -32.06100 1.000 26.80000 ? 268 VAL B CB  1 
ATOM   3703 C CG1 . VAL B 1 224 ? 71.63700 71.60000 -32.38700 1.000 27.33000 ? 268 VAL B CG1 1 
ATOM   3704 C CG2 . VAL B 1 224 ? 71.93300 69.27800 -31.52700 1.000 25.43000 ? 268 VAL B CG2 1 
ATOM   3705 N N   . ILE B 1 225 ? 74.90000 72.08800 -33.77100 1.000 30.99000 ? 269 ILE B N   1 
ATOM   3706 C CA  . ILE B 1 225 ? 75.32200 73.26500 -34.52700 1.000 32.27000 ? 269 ILE B CA  1 
ATOM   3707 C C   . ILE B 1 225 ? 75.83500 72.85900 -35.90400 1.000 31.89000 ? 269 ILE B C   1 
ATOM   3708 O O   . ILE B 1 225 ? 75.47300 73.46100 -36.92200 1.000 32.14000 ? 269 ILE B O   1 
ATOM   3709 C CB  . ILE B 1 225 ? 76.38300 74.05300 -33.73700 1.000 33.70000 ? 269 ILE B CB  1 
ATOM   3710 C CG1 . ILE B 1 225 ? 75.74500 74.73900 -32.52700 1.000 35.22000 ? 269 ILE B CG1 1 
ATOM   3711 C CG2 . ILE B 1 225 ? 77.08100 75.07100 -34.63000 1.000 34.97000 ? 269 ILE B CG2 1 
ATOM   3712 C CD1 . ILE B 1 225 ? 76.74700 75.32200 -31.55900 1.000 33.99000 ? 269 ILE B CD1 1 
ATOM   3713 N N   . SER B 1 226 ? 76.68200 71.82800 -35.95400 1.000 31.46000 ? 270 SER B N   1 
ATOM   3714 C CA  . SER B 1 226 ? 77.23600 71.38000 -37.22800 1.000 31.98000 ? 270 SER B CA  1 
ATOM   3715 C C   . SER B 1 226 ? 76.14300 70.89800 -38.17500 1.000 31.97000 ? 270 SER B C   1 
ATOM   3716 O O   . SER B 1 226 ? 76.18400 71.18100 -39.37800 1.000 32.77000 ? 270 SER B O   1 
ATOM   3717 C CB  . SER B 1 226 ? 78.26600 70.27600 -36.98800 1.000 29.58000 ? 270 SER B CB  1 
ATOM   3718 O OG  . SER B 1 226 ? 79.35500 70.75800 -36.22100 1.000 31.29000 ? 270 SER B OG  1 
ATOM   3719 N N   . TRP B 1 227 ? 75.15300 70.17300 -37.64900 1.000 28.83000 ? 271 TRP B N   1 
ATOM   3720 C CA  . TRP B 1 227 ? 74.06700 69.68500 -38.49400 1.000 26.69000 ? 271 TRP B CA  1 
ATOM   3721 C C   . TRP B 1 227 ? 73.23500 70.83600 -39.04600 1.000 30.77000 ? 271 TRP B C   1 
ATOM   3722 O O   . TRP B 1 227 ? 72.83700 70.81600 -40.21700 1.000 32.82000 ? 271 TRP B O   1 
ATOM   3723 C CB  . TRP B 1 227 ? 73.18800 68.71800 -37.70500 1.000 25.94000 ? 271 TRP B CB  1 
ATOM   3724 C CG  . TRP B 1 227 ? 72.22100 67.95000 -38.54900 1.000 23.41000 ? 271 TRP B CG  1 
ATOM   3725 C CD1 . TRP B 1 227 ? 70.93400 68.29300 -38.84300 1.000 22.57000 ? 271 TRP B CD1 1 
ATOM   3726 C CD2 . TRP B 1 227 ? 72.46200 66.69900 -39.20300 1.000 22.36000 ? 271 TRP B CD2 1 
ATOM   3727 N NE1 . TRP B 1 227 ? 70.35900 67.33500 -39.64200 1.000 22.34000 ? 271 TRP B NE1 1 
ATOM   3728 C CE2 . TRP B 1 227 ? 71.27700 66.34500 -39.87700 1.000 20.66000 ? 271 TRP B CE2 1 
ATOM   3729 C CE3 . TRP B 1 227 ? 73.56500 65.84500 -39.28400 1.000 23.38000 ? 271 TRP B CE3 1 
ATOM   3730 C CZ2 . TRP B 1 227 ? 71.16500 65.17400 -40.62300 1.000 21.89000 ? 271 TRP B CZ2 1 
ATOM   3731 C CZ3 . TRP B 1 227 ? 73.45200 64.68400 -40.02600 1.000 23.40000 ? 271 TRP B CZ3 1 
ATOM   3732 C CH2 . TRP B 1 227 ? 72.26100 64.35900 -40.68500 1.000 21.77000 ? 271 TRP B CH2 1 
ATOM   3733 N N   . LEU B 1 228 ? 72.95500 71.84700 -38.21900 1.000 32.02000 ? 272 LEU B N   1 
ATOM   3734 C CA  . LEU B 1 228 ? 72.23700 73.01800 -38.71400 1.000 31.77000 ? 272 LEU B CA  1 
ATOM   3735 C C   . LEU B 1 228 ? 73.09100 73.80900 -39.69600 1.000 33.18000 ? 272 LEU B C   1 
ATOM   3736 O O   . LEU B 1 228 ? 72.58400 74.31400 -40.70300 1.000 33.66000 ? 272 LEU B O   1 
ATOM   3737 C CB  . LEU B 1 228 ? 71.79800 73.90500 -37.54900 1.000 30.11000 ? 272 LEU B CB  1 
ATOM   3738 C CG  . LEU B 1 228 ? 70.69100 73.36000 -36.64500 1.000 30.06000 ? 272 LEU B CG  1 
ATOM   3739 C CD1 . LEU B 1 228 ? 70.36400 74.35200 -35.53900 1.000 31.95000 ? 272 LEU B CD1 1 
ATOM   3740 C CD2 . LEU B 1 228 ? 69.45000 73.03800 -37.45900 1.000 30.11000 ? 272 LEU B CD2 1 
ATOM   3741 N N   . LYS B 1 229 ? 74.39100 73.92600 -39.42100 1.000 34.66000 ? 273 LYS B N   1 
ATOM   3742 C CA  . LYS B 1 229 ? 75.29000 74.58800 -40.36100 1.000 35.70000 ? 273 LYS B CA  1 
ATOM   3743 C C   . LYS B 1 229 ? 75.32800 73.85700 -41.69700 1.000 33.81000 ? 273 LYS B C   1 
ATOM   3744 O O   . LYS B 1 229 ? 75.26200 74.48400 -42.76100 1.000 35.64000 ? 273 LYS B O   1 
ATOM   3745 C CB  . LYS B 1 229 ? 76.69200 74.67700 -39.76400 1.000 35.68000 ? 273 LYS B CB  1 
ATOM   3746 C CG  . LYS B 1 229 ? 76.87300 75.76000 -38.71300 1.000 36.16000 ? 273 LYS B CG  1 
ATOM   3747 C CD  . LYS B 1 229 ? 76.88500 77.14400 -39.34100 1.000 37.32000 ? 273 LYS B CD  1 
ATOM   3748 C CE  . LYS B 1 229 ? 77.31300 78.19600 -38.33300 1.000 35.45000 ? 273 LYS B CE  1 
ATOM   3749 N NZ  . LYS B 1 229 ? 77.31400 79.56800 -38.91200 1.000 36.97000 ? 273 LYS B NZ  1 
ATOM   3750 N N   . ARG B 1 230 ? 75.41800 72.52700 -41.66000 1.000 33.14000 ? 274 ARG B N   1 
ATOM   3751 C CA  . ARG B 1 230 ? 75.60800 71.76200 -42.88800 1.000 33.34000 ? 274 ARG B CA  1 
ATOM   3752 C C   . ARG B 1 230 ? 74.37500 71.81000 -43.78200 1.000 35.43000 ? 274 ARG B C   1 
ATOM   3753 O O   . ARG B 1 230 ? 74.49800 71.87000 -45.01100 1.000 36.48000 ? 274 ARG B O   1 
ATOM   3754 C CB  . ARG B 1 230 ? 75.97000 70.31600 -42.54600 1.000 32.91000 ? 274 ARG B CB  1 
ATOM   3755 C CG  . ARG B 1 230 ? 75.89500 69.34500 -43.71600 1.000 34.18000 ? 274 ARG B CG  1 
ATOM   3756 C CD  . ARG B 1 230 ? 76.83500 69.74100 -44.84300 1.000 36.34000 ? 274 ARG B CD  1 
ATOM   3757 N NE  . ARG B 1 230 ? 76.64000 68.90300 -46.01900 1.000 34.62000 ? 274 ARG B NE  1 
ATOM   3758 C CZ  . ARG B 1 230 ? 75.66500 69.06800 -46.90300 1.000 34.01000 ? 274 ARG B CZ  1 
ATOM   3759 N NH1 . ARG B 1 230 ? 74.77100 70.03500 -46.77400 1.000 34.78000 ? 274 ARG B NH1 1 
ATOM   3760 N NH2 . ARG B 1 230 ? 75.58200 68.23900 -47.93900 1.000 34.51000 ? 274 ARG B NH2 1 
ATOM   3761 N N   . PHE B 1 231 ? 73.18000 71.79800 -43.19400 1.000 32.64000 ? 275 PHE B N   1 
ATOM   3762 C CA  . PHE B 1 231 ? 71.96300 71.63200 -43.97700 1.000 32.09000 ? 275 PHE B CA  1 
ATOM   3763 C C   . PHE B 1 231 ? 71.07400 72.86400 -44.03100 1.000 33.52000 ? 275 PHE B C   1 
ATOM   3764 O O   . PHE B 1 231 ? 70.38300 73.05700 -45.03400 1.000 34.38000 ? 275 PHE B O   1 
ATOM   3765 C CB  . PHE B 1 231 ? 71.15500 70.44400 -43.44300 1.000 30.78000 ? 275 PHE B CB  1 
ATOM   3766 C CG  . PHE B 1 231 ? 71.86900 69.13000 -43.57800 1.000 30.98000 ? 275 PHE B CG  1 
ATOM   3767 C CD1 . PHE B 1 231 ? 72.01900 68.53800 -44.82100 1.000 29.16000 ? 275 PHE B CD1 1 
ATOM   3768 C CD2 . PHE B 1 231 ? 72.40300 68.49600 -42.46900 1.000 28.87000 ? 275 PHE B CD2 1 
ATOM   3769 C CE1 . PHE B 1 231 ? 72.68000 67.33400 -44.95500 1.000 28.05000 ? 275 PHE B CE1 1 
ATOM   3770 C CE2 . PHE B 1 231 ? 73.06600 67.29000 -42.59800 1.000 28.07000 ? 275 PHE B CE2 1 
ATOM   3771 C CZ  . PHE B 1 231 ? 73.20400 66.70800 -43.84300 1.000 28.18000 ? 275 PHE B CZ  1 
ATOM   3772 N N   . VAL B 1 232 ? 71.06400 73.70300 -42.99400 1.000 34.00000 ? 276 VAL B N   1 
ATOM   3773 C CA  . VAL B 1 232 ? 70.29200 74.93900 -43.09000 1.000 34.87000 ? 276 VAL B CA  1 
ATOM   3774 C C   . VAL B 1 232 ? 71.06700 75.99600 -43.87000 1.000 34.48000 ? 276 VAL B C   1 
ATOM   3775 O O   . VAL B 1 232 ? 70.47100 76.79200 -44.60500 1.000 38.13000 ? 276 VAL B O   1 
ATOM   3776 C CB  . VAL B 1 232 ? 69.89400 75.44700 -41.69300 1.000 33.14000 ? 276 VAL B CB  1 
ATOM   3777 C CG1 . VAL B 1 232 ? 69.08700 76.73600 -41.79600 1.000 33.69000 ? 276 VAL B CG1 1 
ATOM   3778 C CG2 . VAL B 1 232 ? 69.10800 74.38400 -40.94500 1.000 29.29000 ? 276 VAL B CG2 1 
ATOM   3779 N N   . ASP B 1 233 ? 72.39100 76.01600 -43.74100 1.000 33.90000 ? 277 ASP B N   1 
ATOM   3780 C CA  . ASP B 1 233 ? 73.23300 76.97400 -44.44200 1.000 35.98000 ? 277 ASP B CA  1 
ATOM   3781 C C   . ASP B 1 233 ? 73.91300 76.38800 -45.67000 1.000 37.09000 ? 277 ASP B C   1 
ATOM   3782 O O   . ASP B 1 233 ? 74.64300 77.11100 -46.35600 1.000 38.49000 ? 277 ASP B O   1 
ATOM   3783 C CB  . ASP B 1 233 ? 74.30200 77.53000 -43.49400 1.000 38.58000 ? 277 ASP B CB  1 
ATOM   3784 C CG  . ASP B 1 233 ? 73.71600 78.33900 -42.35800 1.000 37.17000 ? 277 ASP B CG  1 
ATOM   3785 O OD1 . ASP B 1 233 ? 72.64900 78.95900 -42.55100 1.000 37.05000 ? 277 ASP B OD1 1 
ATOM   3786 O OD2 . ASP B 1 233 ? 74.33100 78.36000 -41.27100 1.000 37.94000 ? 277 ASP B OD2 1 
ATOM   3787 N N   . GLU B 1 234 ? 73.70200 75.10000 -45.95900 1.000 37.55000 ? 278 GLU B N   1 
ATOM   3788 C CA  . GLU B 1 234 ? 74.43600 74.38500 -47.01000 1.000 37.19000 ? 278 GLU B CA  1 
ATOM   3789 C C   . GLU B 1 234 ? 75.94500 74.50900 -46.81700 1.000 37.35000 ? 278 GLU B C   1 
ATOM   3790 O O   . GLU B 1 234 ? 76.71500 74.40700 -47.77500 1.000 38.26000 ? 278 GLU B O   1 
ATOM   3791 C CB  . GLU B 1 234 ? 74.04100 74.87400 -48.40600 1.000 39.65000 ? 278 GLU B CB  1 
ATOM   3792 C CG  . GLU B 1 234 ? 72.55000 74.89000 -48.66800 1.000 42.02000 ? 278 GLU B CG  1 
ATOM   3793 C CD  . GLU B 1 234 ? 72.19300 75.62900 -49.94400 1.000 47.99000 ? 278 GLU B CD  1 
ATOM   3794 O OE1 . GLU B 1 234 ? 73.00100 76.46400 -50.40600 1.000 49.89000 ? 278 GLU B OE1 1 
ATOM   3795 O OE2 . GLU B 1 234 ? 71.09900 75.37200 -50.48400 1.000 50.70000 ? 278 GLU B OE2 1 
ATOM   3796 N N   . ASP B 1 235 ? 76.37500 74.72000 -45.57400 1.000 36.42000 ? 279 ASP B N   1 
ATOM   3797 C CA  . ASP B 1 235 ? 77.75500 75.09000 -45.26400 1.000 35.96000 ? 279 ASP B CA  1 
ATOM   3798 C C   . ASP B 1 235 ? 78.58600 73.81700 -45.15100 1.000 35.42000 ? 279 ASP B C   1 
ATOM   3799 O O   . ASP B 1 235 ? 78.52800 73.10900 -44.14300 1.000 34.55000 ? 279 ASP B O   1 
ATOM   3800 C CB  . ASP B 1 235 ? 77.80400 75.91500 -43.98100 1.000 38.18000 ? 279 ASP B CB  1 
ATOM   3801 C CG  . ASP B 1 235 ? 79.12300 76.64700 -43.79700 1.000 37.85000 ? 279 ASP B CG  1 
ATOM   3802 O OD1 . ASP B 1 235 ? 80.04500 76.44500 -44.61400 1.000 39.43000 ? 279 ASP B OD1 1 
ATOM   3803 O OD2 . ASP B 1 235 ? 79.23300 77.43200 -42.83200 1.000 38.50000 ? 279 ASP B OD2 1 
ATOM   3804 N N   . THR B 1 236 ? 79.36900 73.52900 -46.18800 1.000 38.97000 ? 280 THR B N   1 
ATOM   3805 C CA  . THR B 1 236 ? 80.23000 72.35600 -46.19000 1.000 36.08000 ? 280 THR B CA  1 
ATOM   3806 C C   . THR B 1 236 ? 81.47500 72.53500 -45.33500 1.000 34.27000 ? 280 THR B C   1 
ATOM   3807 O O   . THR B 1 236 ? 82.25900 71.58900 -45.20700 1.000 35.54000 ? 280 THR B O   1 
ATOM   3808 C CB  . THR B 1 236 ? 80.63800 72.00500 -47.62100 1.000 33.22000 ? 280 THR B CB  1 
ATOM   3809 O OG1 . THR B 1 236 ? 81.30800 73.12500 -48.21300 1.000 36.02000 ? 280 THR B OG1 1 
ATOM   3810 C CG2 . THR B 1 236 ? 79.41000 71.66200 -48.44700 1.000 36.07000 ? 280 THR B CG2 1 
ATOM   3811 N N   . ARG B 1 237 ? 81.68200 73.72100 -44.75900 1.000 32.96000 ? 281 ARG B N   1 
ATOM   3812 C CA  . ARG B 1 237 ? 82.79300 73.90400 -43.83300 1.000 32.82000 ? 281 ARG B CA  1 
ATOM   3813 C C   . ARG B 1 237 ? 82.62100 73.04200 -42.59100 1.000 33.56000 ? 281 ARG B C   1 
ATOM   3814 O O   . ARG B 1 237 ? 83.61000 72.67900 -41.94300 1.000 34.20000 ? 281 ARG B O   1 
ATOM   3815 C CB  . ARG B 1 237 ? 82.92000 75.37600 -43.44200 1.000 36.27000 ? 281 ARG B CB  1 
ATOM   3816 C CG  . ARG B 1 237 ? 83.27900 76.31200 -44.58500 1.000 38.84000 ? 281 ARG B CG  1 
ATOM   3817 C CD  . ARG B 1 237 ? 83.30700 77.75300 -44.10200 1.000 37.38000 ? 281 ARG B CD  1 
ATOM   3818 N NE  . ARG B 1 237 ? 82.02500 78.15300 -43.53500 1.000 39.43000 ? 281 ARG B NE  1 
ATOM   3819 C CZ  . ARG B 1 237 ? 81.78500 79.32900 -42.97200 1.000 40.90000 ? 281 ARG B CZ  1 
ATOM   3820 N NH1 . ARG B 1 237 ? 82.72700 80.25300 -42.87200 1.000 42.16000 ? 281 ARG B NH1 1 
ATOM   3821 N NH2 . ARG B 1 237 ? 80.56900 79.58500 -42.49700 1.000 42.72000 ? 281 ARG B NH2 1 
ATOM   3822 N N   . TYR B 1 238 ? 81.38000 72.70300 -42.24900 1.000 34.23000 ? 282 TYR B N   1 
ATOM   3823 C CA  . TYR B 1 238 ? 81.07000 71.87000 -41.09700 1.000 36.31000 ? 282 TYR B CA  1 
ATOM   3824 C C   . TYR B 1 238 ? 80.89300 70.40300 -41.46600 1.000 35.33000 ? 282 TYR B C   1 
ATOM   3825 O O   . TYR B 1 238 ? 80.37700 69.62600 -40.65600 1.000 34.44000 ? 282 TYR B O   1 
ATOM   3826 C CB  . TYR B 1 238 ? 79.81600 72.39500 -40.39400 1.000 34.38000 ? 282 TYR B CB  1 
ATOM   3827 C CG  . TYR B 1 238 ? 80.02100 73.72000 -39.69100 1.000 38.25000 ? 282 TYR B CG  1 
ATOM   3828 C CD1 . TYR B 1 238 ? 80.08500 74.90800 -40.40900 1.000 38.79000 ? 282 TYR B CD1 1 
ATOM   3829 C CD2 . TYR B 1 238 ? 80.15100 73.78300 -38.30900 1.000 38.94000 ? 282 TYR B CD2 1 
ATOM   3830 C CE1 . TYR B 1 238 ? 80.27400 76.12000 -39.77200 1.000 39.32000 ? 282 TYR B CE1 1 
ATOM   3831 C CE2 . TYR B 1 238 ? 80.33800 74.99200 -37.66200 1.000 36.94000 ? 282 TYR B CE2 1 
ATOM   3832 C CZ  . TYR B 1 238 ? 80.39900 76.15700 -38.40000 1.000 38.67000 ? 282 TYR B CZ  1 
ATOM   3833 O OH  . TYR B 1 238 ? 80.58600 77.36600 -37.76900 1.000 40.75000 ? 282 TYR B OH  1 
ATOM   3834 N N   . SER B 1 239 ? 81.30300 70.00700 -42.67300 1.000 36.45000 ? 283 SER B N   1 
ATOM   3835 C CA  . SER B 1 239 ? 81.24600 68.59900 -43.04600 1.000 33.25000 ? 283 SER B CA  1 
ATOM   3836 C C   . SER B 1 239 ? 82.34800 67.79700 -42.36600 1.000 31.02000 ? 283 SER B C   1 
ATOM   3837 O O   . SER B 1 239 ? 82.18400 66.59400 -42.13400 1.000 31.15000 ? 283 SER B O   1 
ATOM   3838 C CB  . SER B 1 239 ? 81.34000 68.45300 -44.56500 1.000 34.68000 ? 283 SER B CB  1 
ATOM   3839 O OG  . SER B 1 239 ? 80.26600 69.11800 -45.20700 1.000 33.37000 ? 283 SER B OG  1 
ATOM   3840 N N   . GLN B 1 240 ? 83.47000 68.44300 -42.03700 1.000 32.06000 ? 284 GLN B N   1 
ATOM   3841 C CA  . GLN B 1 240 ? 84.57000 67.75500 -41.37000 1.000 34.36000 ? 284 GLN B CA  1 
ATOM   3842 C C   . GLN B 1 240 ? 84.18200 67.23700 -39.99300 1.000 35.86000 ? 284 GLN B C   1 
ATOM   3843 O O   . GLN B 1 240 ? 84.81800 66.30300 -39.49200 1.000 35.84000 ? 284 GLN B O   1 
ATOM   3844 C CB  . GLN B 1 240 ? 85.77500 68.68800 -41.24700 1.000 32.49000 ? 284 GLN B CB  1 
ATOM   3845 C CG  . GLN B 1 240 ? 85.44700 70.02700 -40.60400 1.000 34.38000 ? 284 GLN B CG  1 
ATOM   3846 C CD  . GLN B 1 240 ? 86.67400 70.88700 -40.37800 1.000 34.10000 ? 284 GLN B CD  1 
ATOM   3847 O OE1 . GLN B 1 240 ? 87.71700 70.39900 -39.94200 1.000 38.02000 ? 284 GLN B OE1 1 
ATOM   3848 N NE2 . GLN B 1 240 ? 86.55600 72.17600 -40.67600 1.000 35.63000 ? 284 GLN B NE2 1 
ATOM   3849 N N   . PHE B 1 241 ? 83.16000 67.82200 -39.36900 1.000 33.75000 ? 285 PHE B N   1 
ATOM   3850 C CA  . PHE B 1 241 ? 82.72400 67.39300 -38.04800 1.000 34.28000 ? 285 PHE B CA  1 
ATOM   3851 C C   . PHE B 1 241 ? 81.65900 66.30800 -38.09400 1.000 32.56000 ? 285 PHE B C   1 
ATOM   3852 O O   . PHE B 1 241 ? 81.48100 65.59400 -37.10100 1.000 32.33000 ? 285 PHE B O   1 
ATOM   3853 C CB  . PHE B 1 241 ? 82.19200 68.59100 -37.25500 1.000 33.90000 ? 285 PHE B CB  1 
ATOM   3854 C CG  . PHE B 1 241 ? 83.14400 69.75200 -37.19900 1.000 33.78000 ? 285 PHE B CG  1 
ATOM   3855 C CD1 . PHE B 1 241 ? 84.28700 69.69000 -36.41900 1.000 34.34000 ? 285 PHE B CD1 1 
ATOM   3856 C CD2 . PHE B 1 241 ? 82.89400 70.90500 -37.92400 1.000 33.74000 ? 285 PHE B CD2 1 
ATOM   3857 C CE1 . PHE B 1 241 ? 85.16400 70.75500 -36.36400 1.000 32.82000 ? 285 PHE B CE1 1 
ATOM   3858 C CE2 . PHE B 1 241 ? 83.76700 71.97300 -37.87300 1.000 35.32000 ? 285 PHE B CE2 1 
ATOM   3859 C CZ  . PHE B 1 241 ? 84.90400 71.89900 -37.09200 1.000 36.66000 ? 285 PHE B CZ  1 
ATOM   3860 N N   . LEU B 1 242 ? 80.95500 66.16400 -39.21500 1.000 33.92000 ? 286 LEU B N   1 
ATOM   3861 C CA  . LEU B 1 242 ? 79.89300 65.17600 -39.35900 1.000 30.32000 ? 286 LEU B CA  1 
ATOM   3862 C C   . LEU B 1 242 ? 80.35100 63.90000 -40.05000 1.000 30.25000 ? 286 LEU B C   1 
ATOM   3863 O O   . LEU B 1 242 ? 79.98900 62.80300 -39.61300 1.000 29.53000 ? 286 LEU B O   1 
ATOM   3864 C CB  . LEU B 1 242 ? 78.71700 65.77400 -40.13600 1.000 30.14000 ? 286 LEU B CB  1 
ATOM   3865 C CG  . LEU B 1 242 ? 77.97400 66.93900 -39.48400 1.000 29.33000 ? 286 LEU B CG  1 
ATOM   3866 C CD1 . LEU B 1 242 ? 76.91600 67.48200 -40.42700 1.000 28.97000 ? 286 LEU B CD1 1 
ATOM   3867 C CD2 . LEU B 1 242 ? 77.34800 66.50100 -38.17000 1.000 31.79000 ? 286 LEU B CD2 1 
ATOM   3868 N N   . CYS B 1 243 ? 81.13100 64.01300 -41.12300 1.000 32.71000 ? 287 CYS B N   1 
ATOM   3869 C CA  . CYS B 1 243 ? 81.58900 62.85700 -41.87400 1.000 30.62000 ? 287 CYS B CA  1 
ATOM   3870 C C   . CYS B 1 243 ? 83.11100 62.82600 -41.90800 1.000 27.10000 ? 287 CYS B C   1 
ATOM   3871 O O   . CYS B 1 243 ? 83.73800 63.82700 -42.28500 1.000 28.97000 ? 287 CYS B O   1 
ATOM   3872 C CB  . CYS B 1 243 ? 81.03000 62.87300 -43.30100 1.000 30.48000 ? 287 CYS B CB  1 
ATOM   3873 S SG  . CYS B 1 243 ? 79.23000 62.76900 -43.37600 1.000 33.78000 ? 287 CYS B SG  1 
ATOM   3874 N N   . PRO B 1 244 ? 83.74700 61.70700 -41.52500 1.000 27.42000 ? 288 PRO B N   1 
ATOM   3875 C CA  . PRO B 1 244 ? 83.08700 60.47900 -41.06200 1.000 29.03000 ? 288 PRO B CA  1 
ATOM   3876 C C   . PRO B 1 244 ? 82.49200 60.61100 -39.65800 1.000 30.84000 ? 288 PRO B C   1 
ATOM   3877 O O   . PRO B 1 244 ? 82.55800 61.69100 -39.07000 1.000 30.34000 ? 288 PRO B O   1 
ATOM   3878 C CB  . PRO B 1 244 ? 84.21800 59.44900 -41.08200 1.000 29.31000 ? 288 PRO B CB  1 
ATOM   3879 C CG  . PRO B 1 244 ? 85.45100 60.25100 -40.87100 1.000 28.22000 ? 288 PRO B CG  1 
ATOM   3880 C CD  . PRO B 1 244 ? 85.21300 61.56400 -41.56100 1.000 28.77000 ? 288 PRO B CD  1 
ATOM   3881 N N   . ASN B 1 245 ? 81.92500 59.52200 -39.14600 1.000 30.90000 ? 289 ASN B N   1 
ATOM   3882 C CA  . ASN B 1 245 ? 81.20100 59.57100 -37.88400 1.000 30.59000 ? 289 ASN B CA  1 
ATOM   3883 C C   . ASN B 1 245 ? 82.09800 60.09200 -36.76400 1.000 31.28000 ? 289 ASN B C   1 
ATOM   3884 O O   . ASN B 1 245 ? 83.25900 59.67800 -36.65400 1.000 31.20000 ? 289 ASN B O   1 
ATOM   3885 C CB  . ASN B 1 245 ? 80.67200 58.18600 -37.51700 1.000 29.01000 ? 289 ASN B CB  1 
ATOM   3886 C CG  . ASN B 1 245 ? 79.78600 57.60300 -38.58900 1.000 28.90000 ? 289 ASN B CG  1 
ATOM   3887 O OD1 . ASN B 1 245 ? 79.29200 58.32000 -39.45700 1.000 31.24000 ? 289 ASN B OD1 1 
ATOM   3888 N ND2 . ASN B 1 245 ? 79.57300 56.29400 -38.53500 1.000 30.59000 ? 289 ASN B ND2 1 
ATOM   3889 N N   . PRO B 1 246 ? 81.59900 60.99900 -35.92500 1.000 30.81000 ? 290 PRO B N   1 
ATOM   3890 C CA  . PRO B 1 246 ? 82.39300 61.46600 -34.78500 1.000 30.61000 ? 290 PRO B CA  1 
ATOM   3891 C C   . PRO B 1 246 ? 82.73100 60.32500 -33.83700 1.000 30.02000 ? 290 PRO B C   1 
ATOM   3892 O O   . PRO B 1 246 ? 81.97600 59.36200 -33.68700 1.000 28.46000 ? 290 PRO B O   1 
ATOM   3893 C CB  . PRO B 1 246 ? 81.47600 62.49400 -34.11400 1.000 30.50000 ? 290 PRO B CB  1 
ATOM   3894 C CG  . PRO B 1 246 ? 80.56200 62.95000 -35.20300 1.000 28.59000 ? 290 PRO B CG  1 
ATOM   3895 C CD  . PRO B 1 246 ? 80.33600 61.74200 -36.06200 1.000 29.89000 ? 290 PRO B CD  1 
ATOM   3896 N N   . THR B 1 247 ? 83.88900 60.44700 -33.19300 1.000 33.34000 ? 291 THR B N   1 
ATOM   3897 C CA  . THR B 1 247 ? 84.37400 59.44500 -32.25400 1.000 34.79000 ? 291 THR B CA  1 
ATOM   3898 C C   . THR B 1 247 ? 84.52900 60.02400 -30.85100 1.000 29.87000 ? 291 THR B C   1 
ATOM   3899 O O   . THR B 1 247 ? 85.40400 59.60200 -30.09300 1.000 32.98000 ? 291 THR B O   1 
ATOM   3900 C CB  . THR B 1 247 ? 85.69500 58.84800 -32.73800 1.000 34.77000 ? 291 THR B CB  1 
ATOM   3901 O OG1 . THR B 1 247 ? 86.63400 59.90200 -32.98700 1.000 34.18000 ? 291 THR B OG1 1 
ATOM   3902 C CG2 . THR B 1 247 ? 85.48100 58.05400 -34.02000 1.000 32.73000 ? 291 THR B CG2 1 
ATOM   3903 N N   . ASP B 1 248 ? 83.68500 60.99400 -30.49800 1.000 30.54000 ? 292 ASP B N   1 
ATOM   3904 C CA  . ASP B 1 248 ? 83.75700 61.60700 -29.17800 1.000 30.71000 ? 292 ASP B CA  1 
ATOM   3905 C C   . ASP B 1 248 ? 83.53400 60.56200 -28.09400 1.000 29.30000 ? 292 ASP B C   1 
ATOM   3906 O O   . ASP B 1 248 ? 82.67600 59.68400 -28.22000 1.000 29.71000 ? 292 ASP B O   1 
ATOM   3907 C CB  . ASP B 1 248 ? 82.72300 62.72600 -29.05100 1.000 28.09000 ? 292 ASP B CB  1 
ATOM   3908 C CG  . ASP B 1 248 ? 82.95200 63.84400 -30.04400 1.000 31.53000 ? 292 ASP B CG  1 
ATOM   3909 O OD1 . ASP B 1 248 ? 83.03300 63.55300 -31.25500 1.000 32.17000 ? 292 ASP B OD1 1 
ATOM   3910 O OD2 . ASP B 1 248 ? 83.04400 65.01400 -29.61700 1.000 33.03000 ? 292 ASP B OD2 1 
ATOM   3911 N N   . ARG B 1 249 ? 84.32300 60.66100 -27.02200 1.000 32.52000 ? 293 ARG B N   1 
ATOM   3912 C CA  . ARG B 1 249 ? 84.26500 59.66200 -25.96100 1.000 32.73000 ? 293 ARG B CA  1 
ATOM   3913 C C   . ARG B 1 249 ? 82.90000 59.63800 -25.28700 1.000 28.54000 ? 293 ARG B C   1 
ATOM   3914 O O   . ARG B 1 249 ? 82.49600 58.60700 -24.73700 1.000 26.87000 ? 293 ARG B O   1 
ATOM   3915 C CB  . ARG B 1 249 ? 85.36800 59.92900 -24.93700 1.000 38.61000 ? 293 ARG B CB  1 
ATOM   3916 C CG  . ARG B 1 249 ? 85.62700 58.78600 -23.97000 1.000 39.04000 ? 293 ARG B CG  1 
ATOM   3917 C CD  . ARG B 1 249 ? 86.76900 59.11500 -23.01500 1.000 39.37000 ? 293 ARG B CD  1 
ATOM   3918 N NE  . ARG B 1 249 ? 86.46100 60.25000 -22.15100 1.000 43.61000 ? 293 ARG B NE  1 
ATOM   3919 C CZ  . ARG B 1 249 ? 86.88700 61.49000 -22.35500 1.000 45.94000 ? 293 ARG B CZ  1 
ATOM   3920 N NH1 . ARG B 1 249 ? 87.65200 61.79700 -23.39000 1.000 45.73000 ? 293 ARG B NH1 1 
ATOM   3921 N NH2 . ARG B 1 249 ? 86.53500 62.44500 -21.49900 1.000 42.72000 ? 293 ARG B NH2 1 
ATOM   3922 N N   . ALA B 1 250 ? 82.17300 60.75500 -25.32900 1.000 27.31000 ? 294 ALA B N   1 
ATOM   3923 C CA  . ALA B 1 250 ? 80.82000 60.79600 -24.79300 1.000 26.31000 ? 294 ALA B CA  1 
ATOM   3924 C C   . ALA B 1 250 ? 79.81800 60.04700 -25.66200 1.000 27.35000 ? 294 ALA B C   1 
ATOM   3925 O O   . ALA B 1 250 ? 78.69500 59.80300 -25.20800 1.000 26.19000 ? 294 ALA B O   1 
ATOM   3926 C CB  . ALA B 1 250 ? 80.37300 62.24800 -24.62000 1.000 25.81000 ? 294 ALA B CB  1 
ATOM   3927 N N   . ILE B 1 251 ? 80.19100 59.67700 -26.88400 1.000 29.05000 ? 295 ILE B N   1 
ATOM   3928 C CA  . ILE B 1 251 ? 79.30200 58.96200 -27.79200 1.000 25.75000 ? 295 ILE B CA  1 
ATOM   3929 C C   . ILE B 1 251 ? 79.52100 57.46600 -27.61700 1.000 25.05000 ? 295 ILE B C   1 
ATOM   3930 O O   . ILE B 1 251 ? 80.66500 56.99500 -27.59500 1.000 29.77000 ? 295 ILE B O   1 
ATOM   3931 C CB  . ILE B 1 251 ? 79.54600 59.38700 -29.25000 1.000 27.56000 ? 295 ILE B CB  1 
ATOM   3932 C CG1 . ILE B 1 251 ? 79.47500 60.90900 -29.38400 1.000 26.32000 ? 295 ILE B CG1 1 
ATOM   3933 C CG2 . ILE B 1 251 ? 78.53500 58.72500 -30.17700 1.000 27.38000 ? 295 ILE B CG2 1 
ATOM   3934 C CD1 . ILE B 1 251 ? 79.76700 61.41200 -30.78100 1.000 28.57000 ? 295 ILE B CD1 1 
ATOM   3935 N N   . CYS B 1 252 ? 78.42700 56.71500 -27.48800 1.000 24.97000 ? 296 CYS B N   1 
ATOM   3936 C CA  . CYS B 1 252 ? 78.49700 55.26800 -27.35200 1.000 26.01000 ? 296 CYS B CA  1 
ATOM   3937 C C   . CYS B 1 252 ? 78.06000 54.51800 -28.60200 1.000 27.61000 ? 296 CYS B C   1 
ATOM   3938 O O   . CYS B 1 252 ? 78.28000 53.30400 -28.68100 1.000 25.51000 ? 296 CYS B O   1 
ATOM   3939 C CB  . CYS B 1 252 ? 77.65600 54.80000 -26.15600 1.000 30.35000 ? 296 CYS B CB  1 
ATOM   3940 S SG  . CYS B 1 252 ? 78.62200 54.65500 -24.63800 1.000 37.15000 ? 296 CYS B SG  1 
ATOM   3941 N N   . GLU B 1 253 ? 77.45600 55.20000 -29.57100 1.000 29.87000 ? 297 GLU B N   1 
ATOM   3942 C CA  . GLU B 1 253 ? 77.09400 54.59600 -30.84500 1.000 30.37000 ? 297 GLU B CA  1 
ATOM   3943 C C   . GLU B 1 253 ? 76.74300 55.70700 -31.82100 1.000 28.34000 ? 297 GLU B C   1 
ATOM   3944 O O   . GLU B 1 253 ? 76.08400 56.67900 -31.44600 1.000 26.72000 ? 297 GLU B O   1 
ATOM   3945 C CB  . GLU B 1 253 ? 75.91400 53.62600 -30.69900 1.000 29.83000 ? 297 GLU B CB  1 
ATOM   3946 C CG  . GLU B 1 253 ? 75.54600 52.92000 -31.99000 1.000 31.15000 ? 297 GLU B CG  1 
ATOM   3947 C CD  . GLU B 1 253 ? 74.58800 51.77000 -31.77700 1.000 32.43000 ? 297 GLU B CD  1 
ATOM   3948 O OE1 . GLU B 1 253 ? 74.10900 51.59400 -30.63800 1.000 38.27000 ? 297 GLU B OE1 1 
ATOM   3949 O OE2 . GLU B 1 253 ? 74.31700 51.03700 -32.75000 1.000 35.44000 ? 297 GLU B OE2 1 
ATOM   3950 N N   . TYR B 1 254 ? 77.19000 55.55900 -33.06600 1.000 29.15000 ? 298 TYR B N   1 
ATOM   3951 C CA  . TYR B 1 254 ? 76.91700 56.55000 -34.09600 1.000 28.88000 ? 298 TYR B CA  1 
ATOM   3952 C C   . TYR B 1 254 ? 76.66100 55.84700 -35.41900 1.000 29.44000 ? 298 TYR B C   1 
ATOM   3953 O O   . TYR B 1 254 ? 77.47000 55.02200 -35.85500 1.000 29.06000 ? 298 TYR B O   1 
ATOM   3954 C CB  . TYR B 1 254 ? 78.07700 57.54300 -34.23800 1.000 28.32000 ? 298 TYR B CB  1 
ATOM   3955 C CG  . TYR B 1 254 ? 77.67000 58.87700 -34.82700 1.000 28.81000 ? 298 TYR B CG  1 
ATOM   3956 C CD1 . TYR B 1 254 ? 77.42300 59.01400 -36.18700 1.000 28.53000 ? 298 TYR B CD1 1 
ATOM   3957 C CD2 . TYR B 1 254 ? 77.53500 60.00000 -34.02100 1.000 26.98000 ? 298 TYR B CD2 1 
ATOM   3958 C CE1 . TYR B 1 254 ? 77.05000 60.23100 -36.72700 1.000 26.53000 ? 298 TYR B CE1 1 
ATOM   3959 C CE2 . TYR B 1 254 ? 77.16400 61.22000 -34.55200 1.000 26.63000 ? 298 TYR B CE2 1 
ATOM   3960 C CZ  . TYR B 1 254 ? 76.92200 61.33000 -35.90500 1.000 27.88000 ? 298 TYR B CZ  1 
ATOM   3961 O OH  . TYR B 1 254 ? 76.55400 62.54400 -36.43800 1.000 27.62000 ? 298 TYR B OH  1 
ATOM   3962 N N   . ARG B 1 255 ? 75.53400 56.17300 -36.04500 1.000 29.82000 ? 299 ARG B N   1 
ATOM   3963 C CA  . ARG B 1 255 ? 75.18700 55.69300 -37.37300 1.000 27.13000 ? 299 ARG B CA  1 
ATOM   3964 C C   . ARG B 1 255 ? 74.92300 56.89000 -38.27600 1.000 27.05000 ? 299 ARG B C   1 
ATOM   3965 O O   . ARG B 1 255 ? 74.40100 57.91400 -37.82900 1.000 25.98000 ? 299 ARG B O   1 
ATOM   3966 C CB  . ARG B 1 255 ? 73.95000 54.78600 -37.33600 1.000 26.73000 ? 299 ARG B CB  1 
ATOM   3967 C CG  . ARG B 1 255 ? 74.00800 53.67300 -36.30100 1.000 27.56000 ? 299 ARG B CG  1 
ATOM   3968 C CD  . ARG B 1 255 ? 72.69700 52.89900 -36.25400 1.000 31.12000 ? 299 ARG B CD  1 
ATOM   3969 N NE  . ARG B 1 255 ? 72.69600 51.88700 -35.20400 1.000 34.21000 ? 299 ARG B NE  1 
ATOM   3970 C CZ  . ARG B 1 255 ? 71.69300 51.05400 -34.96300 1.000 32.75000 ? 299 ARG B CZ  1 
ATOM   3971 N NH1 . ARG B 1 255 ? 70.58100 51.08400 -35.67900 1.000 31.29000 ? 299 ARG B NH1 1 
ATOM   3972 N NH2 . ARG B 1 255 ? 71.80900 50.16600 -33.97900 1.000 32.21000 ? 299 ARG B NH2 1 
ATOM   3973 N N   . SER B 1 256 ? 75.28900 56.76100 -39.55000 1.000 29.56000 ? 300 SER B N   1 
ATOM   3974 C CA  . SER B 1 256 ? 75.09000 57.85200 -40.49500 1.000 25.70000 ? 300 SER B CA  1 
ATOM   3975 C C   . SER B 1 256 ? 75.09000 57.30300 -41.91300 1.000 28.02000 ? 300 SER B C   1 
ATOM   3976 O O   . SER B 1 256 ? 75.50400 56.16800 -42.16200 1.000 27.27000 ? 300 SER B O   1 
ATOM   3977 C CB  . SER B 1 256 ? 76.17100 58.92800 -40.34900 1.000 27.87000 ? 300 SER B CB  1 
ATOM   3978 O OG  . SER B 1 256 ? 77.41200 58.46700 -40.85200 1.000 30.84000 ? 300 SER B OG  1 
ATOM   3979 N N   . THR B 1 257 ? 74.61300 58.13300 -42.83900 1.000 30.91000 ? 301 THR B N   1 
ATOM   3980 C CA  . THR B 1 257 ? 74.71000 57.87100 -44.27500 1.000 27.04000 ? 301 THR B CA  1 
ATOM   3981 C C   . THR B 1 257 ? 75.83200 58.68000 -44.91000 1.000 28.22000 ? 301 THR B C   1 
ATOM   3982 O O   . THR B 1 257 ? 75.70200 59.16800 -46.03600 1.000 33.01000 ? 301 THR B O   1 
ATOM   3983 C CB  . THR B 1 257 ? 73.38100 58.16200 -44.96800 1.000 25.10000 ? 301 THR B CB  1 
ATOM   3984 O OG1 . THR B 1 257 ? 72.94000 59.48500 -44.63700 1.000 26.73000 ? 301 THR B OG1 1 
ATOM   3985 C CG2 . THR B 1 257 ? 72.32400 57.15400 -44.54600 1.000 23.23000 ? 301 THR B CG2 1 
ATOM   3986 N N   . CYS B 1 258 ? 76.94500 58.83900 -44.19600 1.000 29.09000 ? 302 CYS B N   1 
ATOM   3987 C CA  . CYS B 1 258 ? 78.07800 59.58400 -44.71800 1.000 29.28000 ? 302 CYS B CA  1 
ATOM   3988 C C   . CYS B 1 258 ? 78.67200 58.86800 -45.93100 1.000 27.41000 ? 302 CYS B C   1 
ATOM   3989 O O   . CYS B 1 258 ? 78.66000 57.63600 -46.00100 1.000 29.89000 ? 302 CYS B O   1 
ATOM   3990 C CB  . CYS B 1 258 ? 79.14600 59.75400 -43.64000 1.000 28.71000 ? 302 CYS B CB  1 
ATOM   3991 S SG  . CYS B 1 258 ? 78.79500 61.03400 -42.41500 1.000 32.27000 ? 302 CYS B SG  1 
ATOM   3992 N N   . PRO B 1 259 ? 79.20700 59.62000 -46.90800 1.000 27.23000 ? 303 PRO B N   1 
ATOM   3993 C CA  . PRO B 1 259 ? 79.24200 61.08800 -46.92100 1.000 25.68000 ? 303 PRO B CA  1 
ATOM   3994 C C   . PRO B 1 259 ? 77.94300 61.71200 -47.42200 1.000 27.01000 ? 303 PRO B C   1 
ATOM   3995 O O   . PRO B 1 259 ? 77.21400 61.09000 -48.19400 1.000 30.31000 ? 303 PRO B O   1 
ATOM   3996 C CB  . PRO B 1 259 ? 80.39500 61.39500 -47.87600 1.000 28.31000 ? 303 PRO B CB  1 
ATOM   3997 C CG  . PRO B 1 259 ? 80.38900 60.25500 -48.82600 1.000 25.96000 ? 303 PRO B CG  1 
ATOM   3998 C CD  . PRO B 1 259 ? 79.95900 59.04500 -48.03700 1.000 26.83000 ? 303 PRO B CD  1 
ATOM   3999 N N   . TYR B 1 260 ? 77.66000 62.93300 -46.97900 1.000 27.42000 ? 304 TYR B N   1 
ATOM   4000 C CA  . TYR B 1 260 ? 76.44400 63.62700 -47.38100 1.000 29.46000 ? 304 TYR B CA  1 
ATOM   4001 C C   . TYR B 1 260 ? 76.65500 64.38700 -48.68600 1.000 33.43000 ? 304 TYR B C   1 
ATOM   4002 O O   . TYR B 1 260 ? 77.08300 65.54200 -48.68300 1.000 34.26000 ? 304 TYR B O   1 
ATOM   4003 C CB  . TYR B 1 260 ? 75.98700 64.58400 -46.27800 1.000 30.15000 ? 304 TYR B CB  1 
ATOM   4004 C CG  . TYR B 1 260 ? 75.72500 63.90600 -44.95100 1.000 29.27000 ? 304 TYR B CG  1 
ATOM   4005 C CD1 . TYR B 1 260 ? 75.10100 62.66700 -44.89300 1.000 25.67000 ? 304 TYR B CD1 1 
ATOM   4006 C CD2 . TYR B 1 260 ? 76.11100 64.50200 -43.75700 1.000 30.58000 ? 304 TYR B CD2 1 
ATOM   4007 C CE1 . TYR B 1 260 ? 74.86200 62.04300 -43.68300 1.000 27.64000 ? 304 TYR B CE1 1 
ATOM   4008 C CE2 . TYR B 1 260 ? 75.87700 63.88500 -42.54200 1.000 28.56000 ? 304 TYR B CE2 1 
ATOM   4009 C CZ  . TYR B 1 260 ? 75.25200 62.65600 -42.51200 1.000 27.40000 ? 304 TYR B CZ  1 
ATOM   4010 O OH  . TYR B 1 260 ? 75.01500 62.03500 -41.30700 1.000 27.11000 ? 304 TYR B OH  1 
HETATM 4011 N N   . NH4 C 2 .   ? 46.23000 69.70300 0.99600   1.000 16.06000 ? 401 NH4 A N   1 
HETATM 4012 C C1  . BTB D 3 .   ? 56.05300 73.54300 4.82600   1.000 29.45000 ? 402 BTB A C1  1 
HETATM 4013 O O1  . BTB D 3 .   ? 55.30700 72.75300 3.94200   1.000 32.03000 ? 402 BTB A O1  1 
HETATM 4014 C C2  . BTB D 3 .   ? 55.28000 74.84400 5.03100   1.000 28.13000 ? 402 BTB A C2  1 
HETATM 4015 C C3  . BTB D 3 .   ? 55.66100 75.81400 3.90700   1.000 29.79000 ? 402 BTB A C3  1 
HETATM 4016 O O3  . BTB D 3 .   ? 56.98000 75.57600 3.49600   1.000 29.34000 ? 402 BTB A O3  1 
HETATM 4017 C C4  . BTB D 3 .   ? 55.66400 75.42800 6.39300   1.000 32.38000 ? 402 BTB A C4  1 
HETATM 4018 O O4  . BTB D 3 .   ? 55.45800 76.81500 6.40200   1.000 32.71000 ? 402 BTB A O4  1 
HETATM 4019 N N   . BTB D 3 .   ? 53.85400 74.54200 4.96400   1.000 30.48000 ? 402 BTB A N   1 
HETATM 4020 C C5  . BTB D 3 .   ? 53.41900 73.80500 6.13300   1.000 31.20000 ? 402 BTB A C5  1 
HETATM 4021 C C6  . BTB D 3 .   ? 52.41200 72.74400 5.70900   1.000 28.71000 ? 402 BTB A C6  1 
HETATM 4022 O O6  . BTB D 3 .   ? 51.87400 72.20300 6.87700   1.000 34.42000 ? 402 BTB A O6  1 
HETATM 4023 C C7  . BTB D 3 .   ? 53.01900 75.72700 4.85700   1.000 29.58000 ? 402 BTB A C7  1 
HETATM 4024 C C8  . BTB D 3 .   ? 52.15000 75.64800 3.60300   1.000 29.04000 ? 402 BTB A C8  1 
HETATM 4025 O O8  . BTB D 3 .   ? 50.92000 75.07300 3.94400   1.000 31.10000 ? 402 BTB A O8  1 
HETATM 4026 C C2  . C9C E 4 .   ? 66.01400 57.78600 10.20000  1.000 23.58000 ? 403 C9C A C2  1 
HETATM 4027 C C3  . C9C E 4 .   ? 67.78100 59.05500 9.40900   1.000 22.84000 ? 403 C9C A C3  1 
HETATM 4028 C C4  . C9C E 4 .   ? 68.71900 60.05100 9.65900   1.000 25.67000 ? 403 C9C A C4  1 
HETATM 4029 C C5  . C9C E 4 .   ? 69.40500 60.64400 8.60600   1.000 25.34000 ? 403 C9C A C5  1 
HETATM 4030 C C6  . C9C E 4 .   ? 70.34400 61.63800 8.85400   1.000 25.84000 ? 403 C9C A C6  1 
HETATM 4031 C C7  . C9C E 4 .   ? 70.60300 62.03700 10.16000  1.000 28.45000 ? 403 C9C A C7  1 
HETATM 4032 C C8  . C9C E 4 .   ? 69.92200 61.44400 11.21600  1.000 28.49000 ? 403 C9C A C8  1 
HETATM 4033 C C1  . C9C E 4 .   ? 66.56900 56.82000 11.24200  1.000 22.80000 ? 403 C9C A C1  1 
HETATM 4034 O O1  . C9C E 4 .   ? 65.53400 55.94300 11.70100  1.000 26.94000 ? 403 C9C A O1  1 
HETATM 4035 O O2  . C9C E 4 .   ? 66.71300 59.04000 10.25400  1.000 25.69000 ? 403 C9C A O2  1 
HETATM 4036 O O3  . C9C E 4 .   ? 67.93400 58.26600 8.47800   1.000 22.92000 ? 403 C9C A O3  1 
HETATM 4037 C C9  . C9C E 4 .   ? 68.98000 60.45200 10.96500  1.000 28.55000 ? 403 C9C A C9  1 
HETATM 4038 C C10 . C9C E 4 .   ? 71.54300 63.02800 10.41100  1.000 34.10000 ? 403 C9C A C10 1 
HETATM 4039 O O4  . C9C E 4 .   ? 71.79600 63.36200 11.58800  1.000 38.28000 ? 403 C9C A O4  1 
HETATM 4040 O O5  . C9C E 4 .   ? 72.14000 63.58000 9.46200   1.000 33.20000 ? 403 C9C A O5  1 
HETATM 4041 C C1  . GOL F 5 .   ? 69.18500 49.22100 -21.82600 1.000 39.87000 ? 401 GOL B C1  1 
HETATM 4042 O O1  . GOL F 5 .   ? 70.40700 49.81000 -22.16900 1.000 39.93000 ? 401 GOL B O1  1 
HETATM 4043 C C2  . GOL F 5 .   ? 68.30400 50.33300 -21.29200 1.000 37.58000 ? 401 GOL B C2  1 
HETATM 4044 O O2  . GOL F 5 .   ? 66.97300 50.15800 -21.62800 1.000 39.83000 ? 401 GOL B O2  1 
HETATM 4045 C C3  . GOL F 5 .   ? 68.56700 50.28200 -19.80000 1.000 39.51000 ? 401 GOL B C3  1 
HETATM 4046 O O3  . GOL F 5 .   ? 67.99400 51.42400 -19.22400 1.000 36.12000 ? 401 GOL B O3  1 
HETATM 4047 C C2  . C9C G 4 .   ? 59.77100 64.40000 -21.74500 1.000 28.07000 ? 402 C9C B C2  1 
HETATM 4048 C C3  . C9C G 4 .   ? 57.98700 63.13900 -22.57600 1.000 30.37000 ? 402 C9C B C3  1 
HETATM 4049 C C4  . C9C G 4 .   ? 57.12800 62.06900 -22.38200 1.000 30.27000 ? 402 C9C B C4  1 
HETATM 4050 C C5  . C9C G 4 .   ? 56.87700 61.17600 -23.41600 1.000 26.69000 ? 402 C9C B C5  1 
HETATM 4051 C C6  . C9C G 4 .   ? 56.01000 60.11000 -23.20700 1.000 27.99000 ? 402 C9C B C6  1 
HETATM 4052 C C7  . C9C G 4 .   ? 55.39400 59.94500 -21.97200 1.000 32.52000 ? 402 C9C B C7  1 
HETATM 4053 C C8  . C9C G 4 .   ? 55.64600 60.84100 -20.94100 1.000 34.13000 ? 402 C9C B C8  1 
HETATM 4054 C C1  . C9C G 4 .   ? 59.34600 65.85900 -21.56800 1.000 26.96000 ? 402 C9C B C1  1 
HETATM 4055 O O1  . C9C G 4 .   ? 60.37100 66.59200 -20.88800 1.000 26.61000 ? 402 C9C B O1  1 
HETATM 4056 O O2  . C9C G 4 .   ? 58.66500 63.53400 -21.46100 1.000 33.16000 ? 402 C9C B O2  1 
HETATM 4057 O O3  . C9C G 4 .   ? 58.05100 63.69200 -23.67200 1.000 27.64000 ? 402 C9C B O3  1 
HETATM 4058 C C9  . C9C G 4 .   ? 56.51400 61.90300 -21.14700 1.000 34.01000 ? 402 C9C B C9  1 
HETATM 4059 C C10 . C9C G 4 .   ? 54.52600 58.88100 -21.76100 1.000 36.47000 ? 402 C9C B C10 1 
HETATM 4060 O O4  . C9C G 4 .   ? 54.02200 58.70300 -20.63000 1.000 41.28000 ? 402 C9C B O4  1 
HETATM 4061 O O5  . C9C G 4 .   ? 54.24900 58.10300 -22.69900 1.000 36.19000 ? 402 C9C B O5  1 
HETATM 4062 O O   . HOH H 6 .   ? 48.05700 35.59400 -8.62700  1.000 30.30000 ? 501 HOH A O   1 
HETATM 4063 O O   . HOH H 6 .   ? 72.50300 57.09800 -7.50000  1.000 30.51000 ? 502 HOH A O   1 
HETATM 4064 O O   . HOH H 6 .   ? 48.51900 43.99300 -7.35000  1.000 28.69000 ? 503 HOH A O   1 
HETATM 4065 O O   . HOH H 6 .   ? 52.94000 39.58000 -14.14600 1.000 29.00000 ? 504 HOH A O   1 
HETATM 4066 O O   . HOH H 6 .   ? 63.15500 58.45800 -7.49200  1.000 22.38000 ? 505 HOH A O   1 
HETATM 4067 O O   . HOH H 6 .   ? 63.01300 74.56700 -0.04100  1.000 22.92000 ? 506 HOH A O   1 
HETATM 4068 O O   . HOH H 6 .   ? 53.73600 43.62900 8.82600   1.000 26.63000 ? 507 HOH A O   1 
HETATM 4069 O O   . HOH H 6 .   ? 38.54400 53.52000 5.93700   1.000 31.18000 ? 508 HOH A O   1 
HETATM 4070 O O   . HOH H 6 .   ? 67.47700 40.62000 8.34800   1.000 27.46000 ? 509 HOH A O   1 
HETATM 4071 O O   . HOH H 6 .   ? 63.96100 38.61100 8.66100   1.000 26.18000 ? 510 HOH A O   1 
HETATM 4072 O O   . HOH H 6 .   ? 65.84800 67.31100 -15.68700 1.000 29.68000 ? 511 HOH A O   1 
HETATM 4073 O O   . HOH H 6 .   ? 42.24800 45.69800 -6.04200  1.000 30.48000 ? 512 HOH A O   1 
HETATM 4074 O O   . HOH H 6 .   ? 75.31100 40.26300 3.60600   1.000 25.46000 ? 513 HOH A O   1 
HETATM 4075 O O   . HOH H 6 .   ? 45.89900 50.22300 4.04100   1.000 24.20000 ? 514 HOH A O   1 
HETATM 4076 O O   . HOH H 6 .   ? 54.33500 69.68300 -9.18800  1.000 24.64000 ? 515 HOH A O   1 
HETATM 4077 O O   . HOH H 6 .   ? 59.22800 74.56800 2.76100   1.000 27.32000 ? 516 HOH A O   1 
HETATM 4078 O O   . HOH H 6 .   ? 73.13900 43.62900 -7.14300  1.000 27.50000 ? 517 HOH A O   1 
HETATM 4079 O O   . HOH H 6 .   ? 70.22500 50.52200 8.76900   1.000 20.87000 ? 518 HOH A O   1 
HETATM 4080 O O   . HOH H 6 .   ? 74.09800 47.81900 -8.24500  1.000 29.58000 ? 519 HOH A O   1 
HETATM 4081 O O   . HOH H 6 .   ? 63.87300 53.62200 9.33400   1.000 19.40000 ? 520 HOH A O   1 
HETATM 4082 O O   . HOH H 6 .   ? 66.85300 69.16900 -11.22100 1.000 30.26000 ? 521 HOH A O   1 
HETATM 4083 O O   . HOH H 6 .   ? 36.74700 51.39900 -8.22300  1.000 30.58000 ? 522 HOH A O   1 
HETATM 4084 O O   . HOH H 6 .   ? 50.77600 46.29000 9.04100   1.000 23.15000 ? 523 HOH A O   1 
HETATM 4085 O O   . HOH H 6 .   ? 65.87700 56.93700 -13.20100 1.000 22.79000 ? 524 HOH A O   1 
HETATM 4086 O O   . HOH H 6 .   ? 49.07200 61.99700 -7.06800  1.000 20.82000 ? 525 HOH A O   1 
HETATM 4087 O O   . HOH H 6 .   ? 75.48200 67.37100 -1.92800  1.000 30.60000 ? 526 HOH A O   1 
HETATM 4088 O O   . HOH H 6 .   ? 48.93600 48.30100 9.47400   1.000 22.06000 ? 527 HOH A O   1 
HETATM 4089 O O   . HOH H 6 .   ? 60.02900 70.04900 8.21800   1.000 23.37000 ? 528 HOH A O   1 
HETATM 4090 O O   . HOH H 6 .   ? 45.97000 30.40800 -6.09500  1.000 34.31000 ? 529 HOH A O   1 
HETATM 4091 O O   . HOH H 6 .   ? 59.73300 42.76700 8.28300   1.000 24.48000 ? 530 HOH A O   1 
HETATM 4092 O O   . HOH H 6 .   ? 49.80700 61.26700 9.68600   1.000 28.50000 ? 531 HOH A O   1 
HETATM 4093 O O   . HOH H 6 .   ? 71.74700 62.74600 -18.31900 1.000 29.01000 ? 532 HOH A O   1 
HETATM 4094 O O   . HOH H 6 .   ? 68.23100 71.88400 0.35300   1.000 26.54000 ? 533 HOH A O   1 
HETATM 4095 O O   . HOH H 6 .   ? 41.52300 46.16400 1.08900   1.000 29.79000 ? 534 HOH A O   1 
HETATM 4096 O O   . HOH H 6 .   ? 62.54900 65.18800 4.30700   1.000 19.86000 ? 535 HOH A O   1 
HETATM 4097 O O   . HOH H 6 .   ? 55.63700 36.66600 -14.68300 1.000 29.43000 ? 536 HOH A O   1 
HETATM 4098 O O   . HOH H 6 .   ? 46.39200 45.40100 -9.53700  1.000 28.50000 ? 537 HOH A O   1 
HETATM 4099 O O   . HOH H 6 .   ? 44.85800 69.76200 6.86700   1.000 29.87000 ? 538 HOH A O   1 
HETATM 4100 O O   . HOH H 6 .   ? 56.53600 52.89300 -14.11300 1.000 28.68000 ? 539 HOH A O   1 
HETATM 4101 O O   . HOH H 6 .   ? 52.29800 73.60400 -2.88200  1.000 29.80000 ? 540 HOH A O   1 
HETATM 4102 O O   . HOH H 6 .   ? 46.20900 60.25500 -14.37500 1.000 32.19000 ? 541 HOH A O   1 
HETATM 4103 O O   . HOH H 6 .   ? 70.16700 56.88300 -14.58700 1.000 24.58000 ? 542 HOH A O   1 
HETATM 4104 O O   . HOH H 6 .   ? 51.62100 43.57800 -8.25600  1.000 27.84000 ? 543 HOH A O   1 
HETATM 4105 O O   . HOH H 6 .   ? 43.73300 60.01400 5.49300   1.000 25.75000 ? 544 HOH A O   1 
HETATM 4106 O O   . HOH H 6 .   ? 48.90800 64.24500 9.34900   1.000 28.43000 ? 545 HOH A O   1 
HETATM 4107 O O   . HOH H 6 .   ? 78.29500 47.34400 2.53500   1.000 33.17000 ? 546 HOH A O   1 
HETATM 4108 O O   . HOH H 6 .   ? 72.403   54.146   18.251    1.000 32.25000 ? 547 HOH A O   1 
HETATM 4109 O O   . HOH H 6 .   ? 38.91400 50.78400 5.59900   1.000 30.19000 ? 548 HOH A O   1 
HETATM 4110 O O   . HOH H 6 .   ? 60.89400 67.72400 -17.79800 1.000 27.01000 ? 549 HOH A O   1 
HETATM 4111 O O   . HOH H 6 .   ? 37.12600 46.39800 -3.19700  1.000 33.19000 ? 550 HOH A O   1 
HETATM 4112 O O   . HOH H 6 .   ? 44.22600 44.50100 -3.83300  1.000 29.53000 ? 551 HOH A O   1 
HETATM 4113 O O   . HOH H 6 .   ? 52.39300 58.09300 11.38600  1.000 26.14000 ? 552 HOH A O   1 
HETATM 4114 O O   . HOH H 6 .   ? 64.84200 71.76800 -5.86900  1.000 24.75000 ? 553 HOH A O   1 
HETATM 4115 O O   . HOH H 6 .   ? 41.59800 62.13100 -5.94000  1.000 26.94000 ? 554 HOH A O   1 
HETATM 4116 O O   . HOH H 6 .   ? 40.68700 55.40100 -11.57000 1.000 30.36000 ? 555 HOH A O   1 
HETATM 4117 O O   . HOH H 6 .   ? 63.99700 33.35500 -1.09200  1.000 32.66000 ? 556 HOH A O   1 
HETATM 4118 O O   . HOH H 6 .   ? 37.555   66.159   -1.943    1.000 27.26000 ? 557 HOH A O   1 
HETATM 4119 O O   . HOH H 6 .   ? 72.20900 46.49100 9.76000   1.000 22.38000 ? 558 HOH A O   1 
HETATM 4120 O O   . HOH H 6 .   ? 61.21300 47.16900 -13.14000 1.000 26.40000 ? 559 HOH A O   1 
HETATM 4121 O O   . HOH H 6 .   ? 77.31700 43.53800 0.94900   1.000 28.40000 ? 560 HOH A O   1 
HETATM 4122 O O   . HOH H 6 .   ? 69.27700 47.49800 9.11600   1.000 21.17000 ? 561 HOH A O   1 
HETATM 4123 O O   . HOH H 6 .   ? 42.23900 60.12900 -12.26500 1.000 29.35000 ? 562 HOH A O   1 
HETATM 4124 O O   . HOH H 6 .   ? 45.14000 38.18000 -14.53600 1.000 41.43000 ? 563 HOH A O   1 
HETATM 4125 O O   . HOH H 6 .   ? 56.90500 72.78300 8.17400   1.000 27.26000 ? 564 HOH A O   1 
HETATM 4126 O O   . HOH H 6 .   ? 68.19000 49.81900 -15.54700 1.000 27.99000 ? 565 HOH A O   1 
HETATM 4127 O O   . HOH H 6 .   ? 39.47800 61.14900 -8.94500  1.000 27.58000 ? 566 HOH A O   1 
HETATM 4128 O O   . HOH H 6 .   ? 63.34100 47.50100 5.95500   1.000 18.84000 ? 567 HOH A O   1 
HETATM 4129 O O   . HOH H 6 .   ? 61.93700 38.97700 -17.52900 1.000 35.63000 ? 568 HOH A O   1 
HETATM 4130 O O   . HOH H 6 .   ? 58.52900 57.57300 -15.83800 1.000 28.48000 ? 569 HOH A O   1 
HETATM 4131 O O   . HOH H 6 .   ? 56.97700 48.69100 12.12800  1.000 28.96000 ? 570 HOH A O   1 
HETATM 4132 O O   . HOH H 6 .   ? 60.42900 64.82400 5.96500   1.000 19.38000 ? 571 HOH A O   1 
HETATM 4133 O O   . HOH H 6 .   ? 66.84400 42.91600 12.07500  1.000 29.48000 ? 572 HOH A O   1 
HETATM 4134 O O   . HOH H 6 .   ? 49.63900 70.05700 -7.91700  1.000 25.91000 ? 573 HOH A O   1 
HETATM 4135 O O   . HOH H 6 .   ? 67.79700 57.69000 -14.75600 1.000 24.94000 ? 574 HOH A O   1 
HETATM 4136 O O   . HOH H 6 .   ? 62.88400 44.85700 -13.64300 1.000 30.80000 ? 575 HOH A O   1 
HETATM 4137 O O   . HOH H 6 .   ? 50.81300 63.92200 12.71700  1.000 30.12000 ? 576 HOH A O   1 
HETATM 4138 O O   . HOH H 6 .   ? 55.08000 49.89500 -16.90200 1.000 32.60000 ? 577 HOH A O   1 
HETATM 4139 O O   . HOH H 6 .   ? 42.24300 48.15500 -2.78600  1.000 29.56000 ? 578 HOH A O   1 
HETATM 4140 O O   . HOH H 6 .   ? 55.23400 72.23900 -7.54400  1.000 26.19000 ? 579 HOH A O   1 
HETATM 4141 O O   . HOH H 6 .   ? 48.85400 68.71600 -11.97300 1.000 28.84000 ? 580 HOH A O   1 
HETATM 4142 O O   . HOH H 6 .   ? 44.53700 68.99800 -2.52000  1.000 27.10000 ? 581 HOH A O   1 
HETATM 4143 O O   . HOH H 6 .   ? 51.23200 34.45400 -8.12700  1.000 28.46000 ? 582 HOH A O   1 
HETATM 4144 O O   . HOH H 6 .   ? 52.81200 73.51600 12.49800  1.000 31.91000 ? 583 HOH A O   1 
HETATM 4145 O O   . HOH H 6 .   ? 71.99900 66.30800 10.50300  1.000 33.68000 ? 584 HOH A O   1 
HETATM 4146 O O   . HOH H 6 .   ? 42.04500 58.64300 6.50500   1.000 27.56000 ? 585 HOH A O   1 
HETATM 4147 O O   . HOH H 6 .   ? 47.64400 40.49100 6.09300   1.000 31.28000 ? 586 HOH A O   1 
HETATM 4148 O O   . HOH H 6 .   ? 39.33900 63.56900 1.32600   1.000 28.40000 ? 587 HOH A O   1 
HETATM 4149 O O   . HOH H 6 .   ? 64.96100 49.92300 13.96500  1.000 23.95000 ? 588 HOH A O   1 
HETATM 4150 O O   . HOH H 6 .   ? 59.79100 72.40400 -17.76100 1.000 29.81000 ? 589 HOH A O   1 
HETATM 4151 O O   . HOH H 6 .   ? 49.58500 53.78800 14.61800  1.000 27.53000 ? 590 HOH A O   1 
HETATM 4152 O O   . HOH H 6 .   ? 35.69800 54.40000 -5.75800  1.000 25.80000 ? 591 HOH A O   1 
HETATM 4153 O O   . HOH H 6 .   ? 71.87500 68.15900 3.49500   1.000 28.82000 ? 592 HOH A O   1 
HETATM 4154 O O   . HOH H 6 .   ? 58.19600 51.39900 14.98900  1.000 24.40000 ? 593 HOH A O   1 
HETATM 4155 O O   . HOH H 6 .   ? 50.02200 57.24400 12.61100  1.000 25.96000 ? 594 HOH A O   1 
HETATM 4156 O O   . HOH H 6 .   ? 60.46200 53.35600 -15.62700 1.000 28.64000 ? 595 HOH A O   1 
HETATM 4157 O O   . HOH H 6 .   ? 40.67800 64.62800 -4.51200  1.000 27.94000 ? 596 HOH A O   1 
HETATM 4158 O O   . HOH H 6 .   ? 61.49200 31.48100 6.34700   1.000 34.55000 ? 597 HOH A O   1 
HETATM 4159 O O   . HOH H 6 .   ? 68.27500 32.72500 3.45100   1.000 25.93000 ? 598 HOH A O   1 
HETATM 4160 O O   . HOH H 6 .   ? 71.01100 35.76300 9.21700   1.000 24.35000 ? 599 HOH A O   1 
HETATM 4161 O O   . HOH H 6 .   ? 42.64200 62.63200 6.53900   1.000 25.48000 ? 600 HOH A O   1 
HETATM 4162 O O   . HOH H 6 .   ? 57.01800 30.45500 3.81200   1.000 37.36000 ? 601 HOH A O   1 
HETATM 4163 O O   . HOH H 6 .   ? 77.33500 36.34100 0.37200   1.000 24.74000 ? 602 HOH A O   1 
HETATM 4164 O O   . HOH H 6 .   ? 68.44100 68.48100 9.82000   1.000 32.65000 ? 603 HOH A O   1 
HETATM 4165 O O   . HOH H 6 .   ? 73.04700 69.32000 -3.90100  1.000 28.25000 ? 604 HOH A O   1 
HETATM 4166 O O   . HOH H 6 .   ? 40.86600 48.13200 8.51800   1.000 32.23000 ? 605 HOH A O   1 
HETATM 4167 O O   . HOH H 6 .   ? 77.62200 41.15900 0.85200   1.000 25.56000 ? 606 HOH A O   1 
HETATM 4168 O O   . HOH H 6 .   ? 59.14000 45.72100 14.75400  1.000 29.95000 ? 607 HOH A O   1 
HETATM 4169 O O   . HOH H 6 .   ? 76.80700 62.69800 -1.84700  1.000 26.69000 ? 608 HOH A O   1 
HETATM 4170 O O   . HOH H 6 .   ? 64.30300 47.07900 -12.65300 1.000 30.02000 ? 609 HOH A O   1 
HETATM 4171 O O   . HOH H 6 .   ? 55.24900 41.31400 10.46400  1.000 32.77000 ? 610 HOH A O   1 
HETATM 4172 O O   . HOH H 6 .   ? 50.71800 38.70800 -15.81100 1.000 32.55000 ? 611 HOH A O   1 
HETATM 4173 O O   . HOH H 6 .   ? 42.12900 60.89400 -3.06400  1.000 27.86000 ? 612 HOH A O   1 
HETATM 4174 O O   . HOH H 6 .   ? 67.26900 71.46100 -5.34900  1.000 25.96000 ? 613 HOH A O   1 
HETATM 4175 O O   . HOH H 6 .   ? 59.12900 74.60800 -2.67200  1.000 22.15000 ? 614 HOH A O   1 
HETATM 4176 O O   . HOH H 6 .   ? 51.05500 36.12800 -14.72700 1.000 29.29000 ? 615 HOH A O   1 
HETATM 4177 O O   . HOH H 6 .   ? 54.62600 48.34400 -14.89900 1.000 32.83000 ? 616 HOH A O   1 
HETATM 4178 O O   . HOH H 6 .   ? 77.233   56.052   0.187     1.000 23.57000 ? 617 HOH A O   1 
HETATM 4179 O O   . HOH H 6 .   ? 53.94400 75.03800 -4.75200  1.000 29.72000 ? 618 HOH A O   1 
HETATM 4180 O O   . HOH H 6 .   ? 52.00000 67.55700 16.30700  1.000 32.35000 ? 619 HOH A O   1 
HETATM 4181 O O   . HOH H 6 .   ? 60.91800 72.23600 7.05100   1.000 23.79000 ? 620 HOH A O   1 
HETATM 4182 O O   . HOH H 6 .   ? 70.93400 68.25200 6.54000   1.000 28.65000 ? 621 HOH A O   1 
HETATM 4183 O O   . HOH H 6 .   ? 34.886   54.138   0.268     1.000 24.11000 ? 622 HOH A O   1 
HETATM 4184 O O   . HOH H 6 .   ? 70.24600 67.55200 -13.71600 1.000 31.46000 ? 623 HOH A O   1 
HETATM 4185 O O   . HOH H 6 .   ? 46.44800 69.94800 -3.63500  1.000 27.57000 ? 624 HOH A O   1 
HETATM 4186 O O   . HOH H 6 .   ? 54.08700 24.77200 -8.58600  1.000 47.95000 ? 625 HOH A O   1 
HETATM 4187 O O   . HOH H 6 .   ? 49.942   72.812   -3.800    1.000 28.86000 ? 626 HOH A O   1 
HETATM 4188 O O   . HOH H 6 .   ? 47.53100 60.29900 9.80700   1.000 31.30000 ? 627 HOH A O   1 
HETATM 4189 O O   . HOH H 6 .   ? 38.23300 53.92300 -11.58400 1.000 34.71000 ? 628 HOH A O   1 
HETATM 4190 O O   . HOH H 6 .   ? 69.93300 62.94600 -10.97600 1.000 28.04000 ? 629 HOH A O   1 
HETATM 4191 O O   . HOH H 6 .   ? 61.77400 73.39800 -2.62100  1.000 24.30000 ? 630 HOH A O   1 
HETATM 4192 O O   . HOH H 6 .   ? 37.79000 51.37000 -10.57400 1.000 32.16000 ? 631 HOH A O   1 
HETATM 4193 O O   . HOH H 6 .   ? 49.50400 72.14000 -6.29400  1.000 27.28000 ? 632 HOH A O   1 
HETATM 4194 O O   . HOH H 6 .   ? 60.73400 42.23600 10.87600  1.000 27.35000 ? 633 HOH A O   1 
HETATM 4195 O O   . HOH H 6 .   ? 34.30400 52.54000 -6.38700  1.000 27.44000 ? 634 HOH A O   1 
HETATM 4196 O O   . HOH H 6 .   ? 65.17500 44.28400 -13.15900 1.000 32.33000 ? 635 HOH A O   1 
HETATM 4197 O O   . HOH H 6 .   ? 63.617   54.083   14.550    1.000 27.26000 ? 636 HOH A O   1 
HETATM 4198 O O   . HOH H 6 .   ? 41.67100 45.91300 -2.04800  1.000 31.15000 ? 637 HOH A O   1 
HETATM 4199 O O   . HOH H 6 .   ? 59.03300 73.92100 6.61900   1.000 27.83000 ? 638 HOH A O   1 
HETATM 4200 O O   . HOH H 6 .   ? 51.77300 61.64300 11.99800  1.000 28.58000 ? 639 HOH A O   1 
HETATM 4201 O O   . HOH H 6 .   ? 43.65200 61.12400 -13.93700 1.000 31.61000 ? 640 HOH A O   1 
HETATM 4202 O O   . HOH H 6 .   ? 40.161   69.106   5.330     1.000 29.03000 ? 641 HOH A O   1 
HETATM 4203 O O   . HOH H 6 .   ? 70.29000 72.83100 1.60900   1.000 29.21000 ? 642 HOH A O   1 
HETATM 4204 O O   . HOH H 6 .   ? 38.51300 48.75300 7.39600   1.000 33.59000 ? 643 HOH A O   1 
HETATM 4205 O O   . HOH H 6 .   ? 49.84900 57.58000 15.33100  1.000 27.42000 ? 644 HOH A O   1 
HETATM 4206 O O   . HOH H 6 .   ? 63.74000 73.95500 -4.75700  1.000 24.40000 ? 645 HOH A O   1 
HETATM 4207 O O   . HOH H 6 .   ? 56.83000 55.93700 -16.55500 1.000 31.15000 ? 646 HOH A O   1 
HETATM 4208 O O   . HOH H 6 .   ? 59.68000 43.32200 15.19800  1.000 29.20000 ? 647 HOH A O   1 
HETATM 4209 O O   . HOH H 6 .   ? 46.42800 62.77000 11.44100  1.000 30.95000 ? 648 HOH A O   1 
HETATM 4210 O O   . HOH H 6 .   ? 67.87200 72.85400 -2.58300  1.000 26.52000 ? 649 HOH A O   1 
HETATM 4211 O O   . HOH I 6 .   ? 57.95300 88.92100 -33.34700 1.000 44.80000 ? 501 HOH B O   1 
HETATM 4212 O O   . HOH I 6 .   ? 54.38300 71.03200 -23.67900 1.000 28.96000 ? 502 HOH B O   1 
HETATM 4213 O O   . HOH I 6 .   ? 56.86000 78.79300 -42.21100 1.000 34.84000 ? 503 HOH B O   1 
HETATM 4214 O O   . HOH I 6 .   ? 47.96800 80.50900 -28.41900 1.000 31.93000 ? 504 HOH B O   1 
HETATM 4215 O O   . HOH I 6 .   ? 48.04200 78.49000 -27.04400 1.000 31.57000 ? 505 HOH B O   1 
HETATM 4216 O O   . HOH I 6 .   ? 78.64300 74.72000 -28.59900 1.000 33.71000 ? 506 HOH B O   1 
HETATM 4217 O O   . HOH I 6 .   ? 82.11600 65.49700 -26.68300 1.000 29.15000 ? 507 HOH B O   1 
HETATM 4218 O O   . HOH I 6 .   ? 79.92600 76.22100 -47.81400 1.000 36.29000 ? 508 HOH B O   1 
HETATM 4219 O O   . HOH I 6 .   ? 82.73700 74.48000 -23.96700 1.000 42.98000 ? 509 HOH B O   1 
HETATM 4220 O O   . HOH I 6 .   ? 60.98300 53.08400 -43.91200 1.000 34.83000 ? 510 HOH B O   1 
HETATM 4221 O O   . HOH I 6 .   ? 68.74600 70.74900 -45.88900 1.000 36.18000 ? 511 HOH B O   1 
HETATM 4222 O O   . HOH I 6 .   ? 61.34900 68.84500 -22.87000 1.000 24.39000 ? 512 HOH B O   1 
HETATM 4223 O O   . HOH I 6 .   ? 69.39000 73.39000 -48.95700 1.000 39.66000 ? 513 HOH B O   1 
HETATM 4224 O O   . HOH I 6 .   ? 50.37100 74.60100 -37.75700 1.000 30.42000 ? 514 HOH B O   1 
HETATM 4225 O O   . HOH I 6 .   ? 81.45600 77.87900 -35.46100 1.000 41.22000 ? 515 HOH B O   1 
HETATM 4226 O O   . HOH I 6 .   ? 46.90800 72.83500 -30.20900 1.000 28.08000 ? 516 HOH B O   1 
HETATM 4227 O O   . HOH I 6 .   ? 65.94600 48.76700 -31.92100 1.000 27.26000 ? 517 HOH B O   1 
HETATM 4228 O O   . HOH I 6 .   ? 49.86200 63.90200 -37.15600 1.000 32.51000 ? 518 HOH B O   1 
HETATM 4229 O O   . HOH I 6 .   ? 67.51900 53.57900 -23.90600 1.000 26.67000 ? 519 HOH B O   1 
HETATM 4230 O O   . HOH I 6 .   ? 48.56800 74.44000 -33.99100 1.000 29.79000 ? 520 HOH B O   1 
HETATM 4231 O O   . HOH I 6 .   ? 83.59200 64.38000 -36.30100 1.000 35.31000 ? 521 HOH B O   1 
HETATM 4232 O O   . HOH I 6 .   ? 68.96000 76.54900 -49.69400 1.000 40.90000 ? 522 HOH B O   1 
HETATM 4233 O O   . HOH I 6 .   ? 62.68700 64.21900 -39.41000 1.000 24.28000 ? 523 HOH B O   1 
HETATM 4234 O O   . HOH I 6 .   ? 46.32400 71.65100 -27.71100 1.000 28.94000 ? 524 HOH B O   1 
HETATM 4235 O O   . HOH I 6 .   ? 73.86100 49.58400 -28.96500 1.000 43.98000 ? 525 HOH B O   1 
HETATM 4236 O O   . HOH I 6 .   ? 77.21000 62.66200 -38.97900 1.000 29.46000 ? 526 HOH B O   1 
HETATM 4237 O O   . HOH I 6 .   ? 60.94800 55.22000 -48.67300 1.000 27.66000 ? 527 HOH B O   1 
HETATM 4238 O O   . HOH I 6 .   ? 70.68600 89.50500 -40.82500 1.000 44.96000 ? 528 HOH B O   1 
HETATM 4239 O O   . HOH I 6 .   ? 59.40600 65.20600 -45.75100 1.000 24.79000 ? 529 HOH B O   1 
HETATM 4240 O O   . HOH I 6 .   ? 64.26300 58.02500 -28.05800 1.000 21.73000 ? 530 HOH B O   1 
HETATM 4241 O O   . HOH I 6 .   ? 52.35600 74.83400 -22.65100 1.000 30.20000 ? 531 HOH B O   1 
HETATM 4242 O O   . HOH I 6 .   ? 73.28200 66.27800 -20.89600 1.000 29.20000 ? 532 HOH B O   1 
HETATM 4243 O O   . HOH I 6 .   ? 79.74800 64.37700 -46.09000 1.000 33.84000 ? 533 HOH B O   1 
HETATM 4244 O O   . HOH I 6 .   ? 77.82700 85.83700 -27.77500 1.000 43.67000 ? 534 HOH B O   1 
HETATM 4245 O O   . HOH I 6 .   ? 77.63500 60.86900 -22.73900 1.000 29.46000 ? 535 HOH B O   1 
HETATM 4246 O O   . HOH I 6 .   ? 61.01700 77.62200 -45.87800 1.000 35.02000 ? 536 HOH B O   1 
HETATM 4247 O O   . HOH I 6 .   ? 75.40000 80.32200 -24.52900 1.000 35.79000 ? 537 HOH B O   1 
HETATM 4248 O O   . HOH I 6 .   ? 63.93800 69.24100 -47.57400 1.000 32.73000 ? 538 HOH B O   1 
HETATM 4249 O O   . HOH I 6 .   ? 55.10300 81.15300 -24.07200 1.000 29.27000 ? 539 HOH B O   1 
HETATM 4250 O O   . HOH I 6 .   ? 70.38700 71.76500 -47.45300 1.000 37.75000 ? 540 HOH B O   1 
HETATM 4251 O O   . HOH I 6 .   ? 53.14400 63.98300 -39.84200 1.000 30.32000 ? 541 HOH B O   1 
HETATM 4252 O O   . HOH I 6 .   ? 70.31500 80.16900 -23.23200 1.000 34.46000 ? 542 HOH B O   1 
HETATM 4253 O O   . HOH I 6 .   ? 56.18500 72.28400 -47.85800 1.000 23.91000 ? 543 HOH B O   1 
HETATM 4254 O O   . HOH I 6 .   ? 60.30200 50.97800 -37.60400 1.000 30.42000 ? 544 HOH B O   1 
HETATM 4255 O O   . HOH I 6 .   ? 62.85300 73.52600 -49.26800 1.000 34.83000 ? 545 HOH B O   1 
HETATM 4256 O O   . HOH I 6 .   ? 63.58100 99.19100 -39.50300 1.000 51.36000 ? 546 HOH B O   1 
HETATM 4257 O O   . HOH I 6 .   ? 54.96100 74.37800 -23.15300 1.000 27.61000 ? 547 HOH B O   1 
HETATM 4258 O O   . HOH I 6 .   ? 78.51300 97.36900 -40.06800 1.000 54.23000 ? 548 HOH B O   1 
HETATM 4259 O O   . HOH I 6 .   ? 73.33400 53.77700 -41.29500 1.000 27.62000 ? 549 HOH B O   1 
HETATM 4260 O O   . HOH I 6 .   ? 84.43600 70.10600 -44.08700 1.000 33.91000 ? 550 HOH B O   1 
HETATM 4261 O O   . HOH I 6 .   ? 62.90300 75.53600 -45.29100 1.000 33.54000 ? 551 HOH B O   1 
HETATM 4262 O O   . HOH I 6 .   ? 54.65600 52.23300 -36.05700 1.000 30.69000 ? 552 HOH B O   1 
HETATM 4263 O O   . HOH I 6 .   ? 88.37000 74.69200 -40.50300 1.000 42.43000 ? 553 HOH B O   1 
HETATM 4264 O O   . HOH I 6 .   ? 78.50100 66.83200 -45.43800 1.000 35.79000 ? 554 HOH B O   1 
HETATM 4265 O O   . HOH I 6 .   ? 55.94400 71.66200 -16.69500 1.000 32.47000 ? 555 HOH B O   1 
HETATM 4266 O O   . HOH I 6 .   ? 84.01700 66.35700 -34.57400 1.000 34.85000 ? 556 HOH B O   1 
HETATM 4267 O O   . HOH I 6 .   ? 61.00900 75.16400 -26.28500 1.000 23.81632 ? 557 HOH B O   1 
HETATM 4268 O O   . HOH I 6 .   ? 50.16000 88.60800 -23.89200 1.000 30.49000 ? 558 HOH B O   1 
HETATM 4269 O O   . HOH I 6 .   ? 62.65000 50.66600 -38.00500 1.000 28.95000 ? 559 HOH B O   1 
HETATM 4270 O O   . HOH I 6 .   ? 67.58500 74.35700 -19.58200 1.000 30.49000 ? 560 HOH B O   1 
HETATM 4271 O O   . HOH I 6 .   ? 78.70000 52.45500 -36.36200 1.000 40.80000 ? 561 HOH B O   1 
HETATM 4272 O O   . HOH I 6 .   ? 66.78600 58.49800 -26.10200 1.000 20.82000 ? 562 HOH B O   1 
HETATM 4273 O O   . HOH I 6 .   ? 77.56700 59.62600 -18.69500 1.000 31.62000 ? 563 HOH B O   1 
HETATM 4274 O O   . HOH I 6 .   ? 79.34900 80.69500 -36.75100 1.000 40.05000 ? 564 HOH B O   1 
HETATM 4275 O O   . HOH I 6 .   ? 65.23600 52.70400 -45.05200 1.000 29.80000 ? 565 HOH B O   1 
HETATM 4276 O O   . HOH I 6 .   ? 75.98900 63.03000 -22.60600 1.000 29.43000 ? 566 HOH B O   1 
HETATM 4277 O O   . HOH I 6 .   ? 83.71200 63.08100 -22.16800 1.000 36.19000 ? 567 HOH B O   1 
HETATM 4278 O O   . HOH I 6 .   ? 50.44500 62.13400 -32.21400 1.000 27.45000 ? 568 HOH B O   1 
HETATM 4279 O O   . HOH I 6 .   ? 83.51700 63.42700 -25.38800 1.000 29.83000 ? 569 HOH B O   1 
HETATM 4280 O O   . HOH I 6 .   ? 77.89000 87.03700 -46.67100 1.000 48.41000 ? 570 HOH B O   1 
HETATM 4281 O O   . HOH I 6 .   ? 65.73800 72.06800 -49.36800 1.000 33.99000 ? 571 HOH B O   1 
HETATM 4282 O O   . HOH I 6 .   ? 80.49900 54.97300 -35.82700 1.000 36.59000 ? 572 HOH B O   1 
HETATM 4283 O O   . HOH I 6 .   ? 66.23500 77.17900 -50.38700 1.000 38.30000 ? 573 HOH B O   1 
HETATM 4284 O O   . HOH I 6 .   ? 59.79000 49.83400 -31.86200 1.000 30.48000 ? 574 HOH B O   1 
HETATM 4285 O O   . HOH I 6 .   ? 74.74600 57.57700 -48.47900 1.000 28.25000 ? 575 HOH B O   1 
HETATM 4286 O O   . HOH I 6 .   ? 57.02100 53.11700 -25.56000 1.000 28.53000 ? 576 HOH B O   1 
HETATM 4287 O O   . HOH I 6 .   ? 79.23100 53.36500 -33.85000 1.000 38.94000 ? 577 HOH B O   1 
HETATM 4288 O O   . HOH I 6 .   ? 48.29700 64.76600 -32.09800 1.000 26.55000 ? 578 HOH B O   1 
HETATM 4289 O O   . HOH I 6 .   ? 66.89700 51.01700 -25.16600 1.000 28.49000 ? 579 HOH B O   1 
HETATM 4290 O O   . HOH I 6 .   ? 60.30000 91.11800 -25.64700 1.000 31.48000 ? 580 HOH B O   1 
HETATM 4291 O O   . HOH I 6 .   ? 48.48100 73.52800 -20.24500 1.000 31.81000 ? 581 HOH B O   1 
HETATM 4292 O O   . HOH I 6 .   ? 87.29000 66.25200 -37.43300 1.000 39.46000 ? 582 HOH B O   1 
HETATM 4293 O O   . HOH I 6 .   ? 63.90200 68.01300 -17.39700 1.000 26.94000 ? 583 HOH B O   1 
HETATM 4294 O O   . HOH I 6 .   ? 68.87600 52.15100 -42.80400 1.000 29.16000 ? 584 HOH B O   1 
HETATM 4295 O O   . HOH I 6 .   ? 56.58700 58.51300 -43.35000 1.000 23.10000 ? 585 HOH B O   1 
HETATM 4296 O O   . HOH I 6 .   ? 56.47600 54.71000 -23.16800 1.000 29.94000 ? 586 HOH B O   1 
HETATM 4297 O O   . HOH I 6 .   ? 77.35000 54.15700 -39.91200 1.000 30.57000 ? 587 HOH B O   1 
HETATM 4298 O O   . HOH I 6 .   ? 64.66100 53.10600 -47.40800 1.000 28.92000 ? 588 HOH B O   1 
HETATM 4299 O O   . HOH I 6 .   ? 66.31300 49.75300 -34.98800 1.000 28.47000 ? 589 HOH B O   1 
HETATM 4300 O O   . HOH I 6 .   ? 84.28300 83.75500 -43.19500 1.000 41.13000 ? 590 HOH B O   1 
HETATM 4301 O O   . HOH I 6 .   ? 86.97800 71.62700 -44.03400 1.000 32.88000 ? 591 HOH B O   1 
HETATM 4302 O O   . HOH I 6 .   ? 60.16000 75.34700 -44.78400 1.000 32.32000 ? 592 HOH B O   1 
HETATM 4303 O O   . HOH I 6 .   ? 48.24400 72.04700 -32.89600 1.000 29.42000 ? 593 HOH B O   1 
HETATM 4304 O O   . HOH I 6 .   ? 45.03200 70.06600 -21.98800 1.000 35.72000 ? 594 HOH B O   1 
HETATM 4305 O O   . HOH I 6 .   ? 66.20800 71.39000 -16.98900 1.000 29.12000 ? 595 HOH B O   1 
HETATM 4306 O O   . HOH I 6 .   ? 69.43000 49.73200 -25.59500 1.000 32.38000 ? 596 HOH B O   1 
HETATM 4307 O O   . HOH I 6 .   ? 78.78800 54.83500 -41.79100 1.000 31.87000 ? 597 HOH B O   1 
HETATM 4308 O O   . HOH I 6 .   ? 66.29000 69.70800 -48.17300 1.000 33.61000 ? 598 HOH B O   1 
HETATM 4309 O O   . HOH I 6 .   ? 77.56800 50.87400 -34.93400 1.000 45.73000 ? 599 HOH B O   1 
HETATM 4310 O O   . HOH I 6 .   ? 73.73300 64.58100 -19.14800 1.000 30.22000 ? 600 HOH B O   1 
HETATM 4311 O O   . HOH I 6 .   ? 47.99800 73.90700 -36.72500 1.000 31.32000 ? 601 HOH B O   1 
HETATM 4312 O O   . HOH I 6 .   ? 57.21900 58.87900 -17.82300 1.000 30.35000 ? 602 HOH B O   1 
HETATM 4313 O O   . HOH I 6 .   ? 76.08000 62.80100 -19.77400 1.000 28.99000 ? 603 HOH B O   1 
HETATM 4314 O O   . HOH I 6 .   ? 63.78700 70.41900 -17.29200 1.000 29.14000 ? 604 HOH B O   1 
HETATM 4315 O O   . HOH I 6 .   ? 64.20600 48.66600 -36.77600 1.000 30.47000 ? 605 HOH B O   1 
HETATM 4316 O O   . HOH I 6 .   ? 83.23200 85.60500 -44.40600 1.000 44.14000 ? 606 HOH B O   1 
HETATM 4317 O O   . HOH I 6 .   ? 60.05700 49.35100 -34.64500 1.000 31.44000 ? 607 HOH B O   1 
HETATM 4318 O O   . HOH I 6 .   ? 66.76300 77.95700 -54.52500 1.000 49.19000 ? 608 HOH B O   1 
HETATM 4319 O O   . HOH I 6 .   ? 68.57200 75.67200 -55.71900 1.000 52.49000 ? 609 HOH B O   1 
# 
