data_8YZZ
# 
_entry.id   8YZZ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YZZ         pdb_00008yzz 10.2210/pdb8yzz/pdb 
WWPDB D_1300046516 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-29 ? 
2 'Structure model' 1 1 2025-05-28 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 2 'Structure model' 'Structure summary'   
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' struct          
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
12 2 'Structure model' '_struct.title'                     
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YZZ 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              liujun@ivdc.chinacdc.cn 
_pdbx_contact_author.name_first         Jun 
_pdbx_contact_author.name_last          Liu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3605-4070 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Shang, B.L.' 1 ? 
'Zhang, J.N.' 2 ? 
'Tian, J.M.'  3 ? 
'Liu, J.'     4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nat.Immunol. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1529-2916 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            26 
_citation.language                  ? 
_citation.page_first                265 
_citation.page_last                 278 
_citation.title                     
'T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41590-024-02051-0 
_citation.pdbx_database_id_PubMed   39875585 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tian, J.'  1  ?                   
primary 'Shang, B.' 2  ?                   
primary 'Zhang, J.' 3  ?                   
primary 'Guo, Y.'   4  0009-0002-7712-6050 
primary 'Li, M.'    5  ?                   
primary 'Hu, Y.'    6  ?                   
primary 'Bai, D.'   7  ?                   
primary 'She, J.'   8  ?                   
primary 'Han, Y.'   9  ?                   
primary 'Guo, P.'   10 ?                   
primary 'Huang, M.' 11 ?                   
primary 'Wang, Y.'  12 ?                   
primary 'Liu, M.'   13 ?                   
primary 'Zhang, J.' 14 ?                   
primary 'Ye, B.'    15 ?                   
primary 'Guo, Y.'   16 ?                   
primary 'Yang, M.'  17 ?                   
primary 'Lin, Y.'   18 ?                   
primary 'Zhang, T.' 19 ?                   
primary 'Sun, X.'   20 ?                   
primary 'Yuan, X.'  21 ?                   
primary 'Zhang, D.' 22 ?                   
primary 'Xu, Z.'    23 ?                   
primary 'Chai, Y.'  24 ?                   
primary 'Qi, J.'    25 0000-0002-9358-4732 
primary 'Liu, K.'   26 0000-0001-9076-2647 
primary 'Tan, S.'   27 0000-0002-2599-4959 
primary 'Zhao, Y.'  28 0000-0002-3370-6398 
primary 'Zhou, J.'  29 0009-0000-4884-5780 
primary 'Song, R.'  30 0000-0003-3624-2514 
primary 'Gao, G.F.' 31 0000-0002-3869-615X 
primary 'Liu, J.'   32 0000-0003-3605-4070 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'MHC class I antigen' 31551.889 1   ? ? ? ? 
2 polymer man Beta-2-microglobulin  11879.356 1   ? ? ? ? 
3 polymer syn 'Spike protein S1'    1266.425  1   ? ? ? ? 
4 water   nat water                 18.015    270 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'HLA class I heavy chain'           
3 ASN-TYR-ASN-TYR-LEU-TYR-ARG-LEU-PHE 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDEETGKVKAHSQTDRENLRI
ALRYYNQSEAGSHTLQMMFGCDVGSDGRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQITKRKWEAAHVAEQQRAYL
EGTCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW
;
;GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDEETGKVKAHSQTDRENLRI
ALRYYNQSEAGSHTLQMMFGCDVGSDGRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQITKRKWEAAHVAEQQRAYL
EGTCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW
;
A ? 
2 'polypeptide(L)' no no 
;MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA
CRVNHVTLSQPKIVKWDRDM
;
;MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA
CRVNHVTLSQPKIVKWDRDM
;
B ? 
3 'polypeptide(L)' no no NYNYLYRLF NYNYLYRLF E ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   HIS n 
1 4   SER n 
1 5   MET n 
1 6   ARG n 
1 7   TYR n 
1 8   PHE n 
1 9   SER n 
1 10  THR n 
1 11  SER n 
1 12  VAL n 
1 13  SER n 
1 14  ARG n 
1 15  PRO n 
1 16  GLY n 
1 17  ARG n 
1 18  GLY n 
1 19  GLU n 
1 20  PRO n 
1 21  ARG n 
1 22  PHE n 
1 23  ILE n 
1 24  ALA n 
1 25  VAL n 
1 26  GLY n 
1 27  TYR n 
1 28  VAL n 
1 29  ASP n 
1 30  ASP n 
1 31  THR n 
1 32  GLN n 
1 33  PHE n 
1 34  VAL n 
1 35  ARG n 
1 36  PHE n 
1 37  ASP n 
1 38  SER n 
1 39  ASP n 
1 40  ALA n 
1 41  ALA n 
1 42  SER n 
1 43  GLN n 
1 44  ARG n 
1 45  MET n 
1 46  GLU n 
1 47  PRO n 
1 48  ARG n 
1 49  ALA n 
1 50  PRO n 
1 51  TRP n 
1 52  ILE n 
1 53  GLU n 
1 54  GLN n 
1 55  GLU n 
1 56  GLY n 
1 57  PRO n 
1 58  GLU n 
1 59  TYR n 
1 60  TRP n 
1 61  ASP n 
1 62  GLU n 
1 63  GLU n 
1 64  THR n 
1 65  GLY n 
1 66  LYS n 
1 67  VAL n 
1 68  LYS n 
1 69  ALA n 
1 70  HIS n 
1 71  SER n 
1 72  GLN n 
1 73  THR n 
1 74  ASP n 
1 75  ARG n 
1 76  GLU n 
1 77  ASN n 
1 78  LEU n 
1 79  ARG n 
1 80  ILE n 
1 81  ALA n 
1 82  LEU n 
1 83  ARG n 
1 84  TYR n 
1 85  TYR n 
1 86  ASN n 
1 87  GLN n 
1 88  SER n 
1 89  GLU n 
1 90  ALA n 
1 91  GLY n 
1 92  SER n 
1 93  HIS n 
1 94  THR n 
1 95  LEU n 
1 96  GLN n 
1 97  MET n 
1 98  MET n 
1 99  PHE n 
1 100 GLY n 
1 101 CYS n 
1 102 ASP n 
1 103 VAL n 
1 104 GLY n 
1 105 SER n 
1 106 ASP n 
1 107 GLY n 
1 108 ARG n 
1 109 PHE n 
1 110 LEU n 
1 111 ARG n 
1 112 GLY n 
1 113 TYR n 
1 114 HIS n 
1 115 GLN n 
1 116 TYR n 
1 117 ALA n 
1 118 TYR n 
1 119 ASP n 
1 120 GLY n 
1 121 LYS n 
1 122 ASP n 
1 123 TYR n 
1 124 ILE n 
1 125 ALA n 
1 126 LEU n 
1 127 LYS n 
1 128 GLU n 
1 129 ASP n 
1 130 LEU n 
1 131 ARG n 
1 132 SER n 
1 133 TRP n 
1 134 THR n 
1 135 ALA n 
1 136 ALA n 
1 137 ASP n 
1 138 MET n 
1 139 ALA n 
1 140 ALA n 
1 141 GLN n 
1 142 ILE n 
1 143 THR n 
1 144 LYS n 
1 145 ARG n 
1 146 LYS n 
1 147 TRP n 
1 148 GLU n 
1 149 ALA n 
1 150 ALA n 
1 151 HIS n 
1 152 VAL n 
1 153 ALA n 
1 154 GLU n 
1 155 GLN n 
1 156 GLN n 
1 157 ARG n 
1 158 ALA n 
1 159 TYR n 
1 160 LEU n 
1 161 GLU n 
1 162 GLY n 
1 163 THR n 
1 164 CYS n 
1 165 VAL n 
1 166 ASP n 
1 167 GLY n 
1 168 LEU n 
1 169 ARG n 
1 170 ARG n 
1 171 TYR n 
1 172 LEU n 
1 173 GLU n 
1 174 ASN n 
1 175 GLY n 
1 176 LYS n 
1 177 GLU n 
1 178 THR n 
1 179 LEU n 
1 180 GLN n 
1 181 ARG n 
1 182 THR n 
1 183 ASP n 
1 184 PRO n 
1 185 PRO n 
1 186 LYS n 
1 187 THR n 
1 188 HIS n 
1 189 MET n 
1 190 THR n 
1 191 HIS n 
1 192 HIS n 
1 193 PRO n 
1 194 ILE n 
1 195 SER n 
1 196 ASP n 
1 197 HIS n 
1 198 GLU n 
1 199 ALA n 
1 200 THR n 
1 201 LEU n 
1 202 ARG n 
1 203 CYS n 
1 204 TRP n 
1 205 ALA n 
1 206 LEU n 
1 207 GLY n 
1 208 PHE n 
1 209 TYR n 
1 210 PRO n 
1 211 ALA n 
1 212 GLU n 
1 213 ILE n 
1 214 THR n 
1 215 LEU n 
1 216 THR n 
1 217 TRP n 
1 218 GLN n 
1 219 ARG n 
1 220 ASP n 
1 221 GLY n 
1 222 GLU n 
1 223 ASP n 
1 224 GLN n 
1 225 THR n 
1 226 GLN n 
1 227 ASP n 
1 228 THR n 
1 229 GLU n 
1 230 LEU n 
1 231 VAL n 
1 232 GLU n 
1 233 THR n 
1 234 ARG n 
1 235 PRO n 
1 236 ALA n 
1 237 GLY n 
1 238 ASP n 
1 239 GLY n 
1 240 THR n 
1 241 PHE n 
1 242 GLN n 
1 243 LYS n 
1 244 TRP n 
1 245 ALA n 
1 246 ALA n 
1 247 VAL n 
1 248 VAL n 
1 249 VAL n 
1 250 PRO n 
1 251 SER n 
1 252 GLY n 
1 253 GLU n 
1 254 GLU n 
1 255 GLN n 
1 256 ARG n 
1 257 TYR n 
1 258 THR n 
1 259 CYS n 
1 260 HIS n 
1 261 VAL n 
1 262 GLN n 
1 263 HIS n 
1 264 GLU n 
1 265 GLY n 
1 266 LEU n 
1 267 PRO n 
1 268 LYS n 
1 269 PRO n 
1 270 LEU n 
1 271 THR n 
1 272 LEU n 
1 273 ARG n 
1 274 TRP n 
2 1   MET n 
2 2   ILE n 
2 3   GLN n 
2 4   ARG n 
2 5   THR n 
2 6   PRO n 
2 7   LYS n 
2 8   ILE n 
2 9   GLN n 
2 10  VAL n 
2 11  TYR n 
2 12  SER n 
2 13  ARG n 
2 14  HIS n 
2 15  PRO n 
2 16  ALA n 
2 17  GLU n 
2 18  ASN n 
2 19  GLY n 
2 20  LYS n 
2 21  SER n 
2 22  ASN n 
2 23  PHE n 
2 24  LEU n 
2 25  ASN n 
2 26  CYS n 
2 27  TYR n 
2 28  VAL n 
2 29  SER n 
2 30  GLY n 
2 31  PHE n 
2 32  HIS n 
2 33  PRO n 
2 34  SER n 
2 35  ASP n 
2 36  ILE n 
2 37  GLU n 
2 38  VAL n 
2 39  ASP n 
2 40  LEU n 
2 41  LEU n 
2 42  LYS n 
2 43  ASN n 
2 44  GLY n 
2 45  GLU n 
2 46  ARG n 
2 47  ILE n 
2 48  GLU n 
2 49  LYS n 
2 50  VAL n 
2 51  GLU n 
2 52  HIS n 
2 53  SER n 
2 54  ASP n 
2 55  LEU n 
2 56  SER n 
2 57  PHE n 
2 58  SER n 
2 59  LYS n 
2 60  ASP n 
2 61  TRP n 
2 62  SER n 
2 63  PHE n 
2 64  TYR n 
2 65  LEU n 
2 66  LEU n 
2 67  TYR n 
2 68  TYR n 
2 69  THR n 
2 70  GLU n 
2 71  PHE n 
2 72  THR n 
2 73  PRO n 
2 74  THR n 
2 75  GLU n 
2 76  LYS n 
2 77  ASP n 
2 78  GLU n 
2 79  TYR n 
2 80  ALA n 
2 81  CYS n 
2 82  ARG n 
2 83  VAL n 
2 84  ASN n 
2 85  HIS n 
2 86  VAL n 
2 87  THR n 
2 88  LEU n 
2 89  SER n 
2 90  GLN n 
2 91  PRO n 
2 92  LYS n 
2 93  ILE n 
2 94  VAL n 
2 95  LYS n 
2 96  TRP n 
2 97  ASP n 
2 98  ARG n 
2 99  ASP n 
2 100 MET n 
3 1   ASN n 
3 2   TYR n 
3 3   ASN n 
3 4   TYR n 
3 5   LEU n 
3 6   TYR n 
3 7   ARG n 
3 8   LEU n 
3 9   PHE n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 274 human ? HLA-A                      ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 100 human ? 'B2M, CDABP0092, HDCMA22P' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_src_syn.entity_id              3 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       9 
_pdbx_entity_src_syn.organism_scientific    'Severe acute respiratory syndrome coronavirus 2' 
_pdbx_entity_src_syn.organism_common_name   '2019-nCoV, SARS-CoV-2' 
_pdbx_entity_src_syn.ncbi_taxonomy_id       2697049 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   1   1   GLY GLY A . n 
A 1 2   SER 2   2   2   SER SER A . n 
A 1 3   HIS 3   3   3   HIS HIS A . n 
A 1 4   SER 4   4   4   SER SER A . n 
A 1 5   MET 5   5   5   MET MET A . n 
A 1 6   ARG 6   6   6   ARG ARG A . n 
A 1 7   TYR 7   7   7   TYR TYR A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   SER 9   9   9   SER SER A . n 
A 1 10  THR 10  10  10  THR THR A . n 
A 1 11  SER 11  11  11  SER SER A . n 
A 1 12  VAL 12  12  12  VAL VAL A . n 
A 1 13  SER 13  13  13  SER SER A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  PRO 15  15  15  PRO PRO A . n 
A 1 16  GLY 16  16  16  GLY GLY A . n 
A 1 17  ARG 17  17  17  ARG ARG A . n 
A 1 18  GLY 18  18  18  GLY GLY A . n 
A 1 19  GLU 19  19  19  GLU GLU A . n 
A 1 20  PRO 20  20  20  PRO PRO A . n 
A 1 21  ARG 21  21  21  ARG ARG A . n 
A 1 22  PHE 22  22  22  PHE PHE A . n 
A 1 23  ILE 23  23  23  ILE ILE A . n 
A 1 24  ALA 24  24  24  ALA ALA A . n 
A 1 25  VAL 25  25  25  VAL VAL A . n 
A 1 26  GLY 26  26  26  GLY GLY A . n 
A 1 27  TYR 27  27  27  TYR TYR A . n 
A 1 28  VAL 28  28  28  VAL VAL A . n 
A 1 29  ASP 29  29  29  ASP ASP A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  THR 31  31  31  THR THR A . n 
A 1 32  GLN 32  32  32  GLN GLN A . n 
A 1 33  PHE 33  33  33  PHE PHE A . n 
A 1 34  VAL 34  34  34  VAL VAL A . n 
A 1 35  ARG 35  35  35  ARG ARG A . n 
A 1 36  PHE 36  36  36  PHE PHE A . n 
A 1 37  ASP 37  37  37  ASP ASP A . n 
A 1 38  SER 38  38  38  SER SER A . n 
A 1 39  ASP 39  39  39  ASP ASP A . n 
A 1 40  ALA 40  40  40  ALA ALA A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  GLN 43  43  43  GLN GLN A . n 
A 1 44  ARG 44  44  44  ARG ARG A . n 
A 1 45  MET 45  45  45  MET MET A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  PRO 47  47  47  PRO PRO A . n 
A 1 48  ARG 48  48  48  ARG ARG A . n 
A 1 49  ALA 49  49  49  ALA ALA A . n 
A 1 50  PRO 50  50  50  PRO PRO A . n 
A 1 51  TRP 51  51  51  TRP TRP A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  GLU 53  53  53  GLU GLU A . n 
A 1 54  GLN 54  54  54  GLN GLN A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  GLY 56  56  56  GLY GLY A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  TYR 59  59  59  TYR TYR A . n 
A 1 60  TRP 60  60  60  TRP TRP A . n 
A 1 61  ASP 61  61  61  ASP ASP A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  GLU 63  63  63  GLU GLU A . n 
A 1 64  THR 64  64  64  THR THR A . n 
A 1 65  GLY 65  65  65  GLY GLY A . n 
A 1 66  LYS 66  66  66  LYS LYS A . n 
A 1 67  VAL 67  67  67  VAL VAL A . n 
A 1 68  LYS 68  68  68  LYS LYS A . n 
A 1 69  ALA 69  69  69  ALA ALA A . n 
A 1 70  HIS 70  70  70  HIS HIS A . n 
A 1 71  SER 71  71  71  SER SER A . n 
A 1 72  GLN 72  72  72  GLN GLN A . n 
A 1 73  THR 73  73  73  THR THR A . n 
A 1 74  ASP 74  74  74  ASP ASP A . n 
A 1 75  ARG 75  75  75  ARG ARG A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  ALA 81  81  81  ALA ALA A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  TYR 84  84  84  TYR TYR A . n 
A 1 85  TYR 85  85  85  TYR TYR A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  GLN 87  87  87  GLN GLN A . n 
A 1 88  SER 88  88  88  SER SER A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  GLY 91  91  91  GLY GLY A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  HIS 93  93  93  HIS HIS A . n 
A 1 94  THR 94  94  94  THR THR A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  GLN 96  96  96  GLN GLN A . n 
A 1 97  MET 97  97  97  MET MET A . n 
A 1 98  MET 98  98  98  MET MET A . n 
A 1 99  PHE 99  99  99  PHE PHE A . n 
A 1 100 GLY 100 100 100 GLY GLY A . n 
A 1 101 CYS 101 101 101 CYS CYS A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 GLY 104 104 104 GLY GLY A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 ASP 106 106 106 ASP ASP A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 ARG 108 108 108 ARG ARG A . n 
A 1 109 PHE 109 109 109 PHE PHE A . n 
A 1 110 LEU 110 110 110 LEU LEU A . n 
A 1 111 ARG 111 111 111 ARG ARG A . n 
A 1 112 GLY 112 112 112 GLY GLY A . n 
A 1 113 TYR 113 113 113 TYR TYR A . n 
A 1 114 HIS 114 114 114 HIS HIS A . n 
A 1 115 GLN 115 115 115 GLN GLN A . n 
A 1 116 TYR 116 116 116 TYR TYR A . n 
A 1 117 ALA 117 117 117 ALA ALA A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASP 119 119 119 ASP ASP A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 ASP 122 122 122 ASP ASP A . n 
A 1 123 TYR 123 123 123 TYR TYR A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 ALA 125 125 125 ALA ALA A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 LYS 127 127 127 LYS LYS A . n 
A 1 128 GLU 128 128 128 GLU GLU A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 TRP 133 133 133 TRP TRP A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 ALA 135 135 135 ALA ALA A . n 
A 1 136 ALA 136 136 136 ALA ALA A . n 
A 1 137 ASP 137 137 137 ASP ASP A . n 
A 1 138 MET 138 138 138 MET MET A . n 
A 1 139 ALA 139 139 139 ALA ALA A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 GLN 141 141 141 GLN GLN A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 LYS 144 144 144 LYS LYS A . n 
A 1 145 ARG 145 145 145 ARG ARG A . n 
A 1 146 LYS 146 146 146 LYS LYS A . n 
A 1 147 TRP 147 147 147 TRP TRP A . n 
A 1 148 GLU 148 148 148 GLU GLU A . n 
A 1 149 ALA 149 149 149 ALA ALA A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 HIS 151 151 151 HIS HIS A . n 
A 1 152 VAL 152 152 152 VAL VAL A . n 
A 1 153 ALA 153 153 153 ALA ALA A . n 
A 1 154 GLU 154 154 154 GLU GLU A . n 
A 1 155 GLN 155 155 155 GLN GLN A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 LEU 160 160 160 LEU LEU A . n 
A 1 161 GLU 161 161 161 GLU GLU A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 THR 163 163 163 THR THR A . n 
A 1 164 CYS 164 164 164 CYS CYS A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 ASP 166 166 166 ASP ASP A . n 
A 1 167 GLY 167 167 167 GLY GLY A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 ARG 169 169 169 ARG ARG A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 TYR 171 171 171 TYR TYR A . n 
A 1 172 LEU 172 172 172 LEU LEU A . n 
A 1 173 GLU 173 173 173 GLU GLU A . n 
A 1 174 ASN 174 174 174 ASN ASN A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 LYS 176 176 176 LYS LYS A . n 
A 1 177 GLU 177 177 177 GLU GLU A . n 
A 1 178 THR 178 178 178 THR THR A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 GLN 180 180 180 GLN GLN A . n 
A 1 181 ARG 181 181 181 ARG ARG A . n 
A 1 182 THR 182 182 182 THR THR A . n 
A 1 183 ASP 183 183 183 ASP ASP A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PRO 185 185 185 PRO PRO A . n 
A 1 186 LYS 186 186 186 LYS LYS A . n 
A 1 187 THR 187 187 187 THR THR A . n 
A 1 188 HIS 188 188 188 HIS HIS A . n 
A 1 189 MET 189 189 189 MET MET A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 HIS 191 191 191 HIS HIS A . n 
A 1 192 HIS 192 192 192 HIS HIS A . n 
A 1 193 PRO 193 193 193 PRO PRO A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 ASP 196 196 196 ASP ASP A . n 
A 1 197 HIS 197 197 197 HIS HIS A . n 
A 1 198 GLU 198 198 198 GLU GLU A . n 
A 1 199 ALA 199 199 199 ALA ALA A . n 
A 1 200 THR 200 200 200 THR THR A . n 
A 1 201 LEU 201 201 201 LEU LEU A . n 
A 1 202 ARG 202 202 202 ARG ARG A . n 
A 1 203 CYS 203 203 203 CYS CYS A . n 
A 1 204 TRP 204 204 204 TRP TRP A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 GLY 207 207 207 GLY GLY A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 PRO 210 210 210 PRO PRO A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 GLU 212 212 212 GLU GLU A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 THR 214 214 214 THR THR A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 THR 216 216 216 THR THR A . n 
A 1 217 TRP 217 217 217 TRP TRP A . n 
A 1 218 GLN 218 218 218 GLN GLN A . n 
A 1 219 ARG 219 219 219 ARG ARG A . n 
A 1 220 ASP 220 220 220 ASP ASP A . n 
A 1 221 GLY 221 221 221 GLY GLY A . n 
A 1 222 GLU 222 222 222 GLU GLU A . n 
A 1 223 ASP 223 223 223 ASP ASP A . n 
A 1 224 GLN 224 224 224 GLN GLN A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 GLN 226 226 226 GLN GLN A . n 
A 1 227 ASP 227 227 227 ASP ASP A . n 
A 1 228 THR 228 228 228 THR THR A . n 
A 1 229 GLU 229 229 229 GLU GLU A . n 
A 1 230 LEU 230 230 230 LEU LEU A . n 
A 1 231 VAL 231 231 231 VAL VAL A . n 
A 1 232 GLU 232 232 232 GLU GLU A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 ARG 234 234 234 ARG ARG A . n 
A 1 235 PRO 235 235 235 PRO PRO A . n 
A 1 236 ALA 236 236 236 ALA ALA A . n 
A 1 237 GLY 237 237 237 GLY GLY A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 GLY 239 239 239 GLY GLY A . n 
A 1 240 THR 240 240 240 THR THR A . n 
A 1 241 PHE 241 241 241 PHE PHE A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 LYS 243 243 243 LYS LYS A . n 
A 1 244 TRP 244 244 244 TRP TRP A . n 
A 1 245 ALA 245 245 245 ALA ALA A . n 
A 1 246 ALA 246 246 246 ALA ALA A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 VAL 248 248 248 VAL VAL A . n 
A 1 249 VAL 249 249 249 VAL VAL A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 SER 251 251 251 SER SER A . n 
A 1 252 GLY 252 252 252 GLY GLY A . n 
A 1 253 GLU 253 253 253 GLU GLU A . n 
A 1 254 GLU 254 254 254 GLU GLU A . n 
A 1 255 GLN 255 255 255 GLN GLN A . n 
A 1 256 ARG 256 256 256 ARG ARG A . n 
A 1 257 TYR 257 257 257 TYR TYR A . n 
A 1 258 THR 258 258 258 THR THR A . n 
A 1 259 CYS 259 259 259 CYS CYS A . n 
A 1 260 HIS 260 260 260 HIS HIS A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 GLN 262 262 262 GLN GLN A . n 
A 1 263 HIS 263 263 263 HIS HIS A . n 
A 1 264 GLU 264 264 264 GLU GLU A . n 
A 1 265 GLY 265 265 265 GLY GLY A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 PRO 267 267 267 PRO PRO A . n 
A 1 268 LYS 268 268 268 LYS LYS A . n 
A 1 269 PRO 269 269 269 PRO PRO A . n 
A 1 270 LEU 270 270 270 LEU LEU A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 ARG 273 273 273 ARG ARG A . n 
A 1 274 TRP 274 274 274 TRP TRP A . n 
B 2 1   MET 1   0   0   MET MET B . n 
B 2 2   ILE 2   1   1   ILE ILE B . n 
B 2 3   GLN 3   2   2   GLN GLN B . n 
B 2 4   ARG 4   3   3   ARG ARG B . n 
B 2 5   THR 5   4   4   THR THR B . n 
B 2 6   PRO 6   5   5   PRO PRO B . n 
B 2 7   LYS 7   6   6   LYS LYS B . n 
B 2 8   ILE 8   7   7   ILE ILE B . n 
B 2 9   GLN 9   8   8   GLN GLN B . n 
B 2 10  VAL 10  9   9   VAL VAL B . n 
B 2 11  TYR 11  10  10  TYR TYR B . n 
B 2 12  SER 12  11  11  SER SER B . n 
B 2 13  ARG 13  12  12  ARG ARG B . n 
B 2 14  HIS 14  13  13  HIS HIS B . n 
B 2 15  PRO 15  14  14  PRO PRO B . n 
B 2 16  ALA 16  15  15  ALA ALA B . n 
B 2 17  GLU 17  16  16  GLU GLU B . n 
B 2 18  ASN 18  17  17  ASN ASN B . n 
B 2 19  GLY 19  18  18  GLY GLY B . n 
B 2 20  LYS 20  19  19  LYS LYS B . n 
B 2 21  SER 21  20  20  SER SER B . n 
B 2 22  ASN 22  21  21  ASN ASN B . n 
B 2 23  PHE 23  22  22  PHE PHE B . n 
B 2 24  LEU 24  23  23  LEU LEU B . n 
B 2 25  ASN 25  24  24  ASN ASN B . n 
B 2 26  CYS 26  25  25  CYS CYS B . n 
B 2 27  TYR 27  26  26  TYR TYR B . n 
B 2 28  VAL 28  27  27  VAL VAL B . n 
B 2 29  SER 29  28  28  SER SER B . n 
B 2 30  GLY 30  29  29  GLY GLY B . n 
B 2 31  PHE 31  30  30  PHE PHE B . n 
B 2 32  HIS 32  31  31  HIS HIS B . n 
B 2 33  PRO 33  32  32  PRO PRO B . n 
B 2 34  SER 34  33  33  SER SER B . n 
B 2 35  ASP 35  34  34  ASP ASP B . n 
B 2 36  ILE 36  35  35  ILE ILE B . n 
B 2 37  GLU 37  36  36  GLU GLU B . n 
B 2 38  VAL 38  37  37  VAL VAL B . n 
B 2 39  ASP 39  38  38  ASP ASP B . n 
B 2 40  LEU 40  39  39  LEU LEU B . n 
B 2 41  LEU 41  40  40  LEU LEU B . n 
B 2 42  LYS 42  41  41  LYS LYS B . n 
B 2 43  ASN 43  42  42  ASN ASN B . n 
B 2 44  GLY 44  43  43  GLY GLY B . n 
B 2 45  GLU 45  44  44  GLU GLU B . n 
B 2 46  ARG 46  45  45  ARG ARG B . n 
B 2 47  ILE 47  46  46  ILE ILE B . n 
B 2 48  GLU 48  47  47  GLU GLU B . n 
B 2 49  LYS 49  48  48  LYS LYS B . n 
B 2 50  VAL 50  49  49  VAL VAL B . n 
B 2 51  GLU 51  50  50  GLU GLU B . n 
B 2 52  HIS 52  51  51  HIS HIS B . n 
B 2 53  SER 53  52  52  SER SER B . n 
B 2 54  ASP 54  53  53  ASP ASP B . n 
B 2 55  LEU 55  54  54  LEU LEU B . n 
B 2 56  SER 56  55  55  SER SER B . n 
B 2 57  PHE 57  56  56  PHE PHE B . n 
B 2 58  SER 58  57  57  SER SER B . n 
B 2 59  LYS 59  58  58  LYS LYS B . n 
B 2 60  ASP 60  59  59  ASP ASP B . n 
B 2 61  TRP 61  60  60  TRP TRP B . n 
B 2 62  SER 62  61  61  SER SER B . n 
B 2 63  PHE 63  62  62  PHE PHE B . n 
B 2 64  TYR 64  63  63  TYR TYR B . n 
B 2 65  LEU 65  64  64  LEU LEU B . n 
B 2 66  LEU 66  65  65  LEU LEU B . n 
B 2 67  TYR 67  66  66  TYR TYR B . n 
B 2 68  TYR 68  67  67  TYR TYR B . n 
B 2 69  THR 69  68  68  THR THR B . n 
B 2 70  GLU 70  69  69  GLU GLU B . n 
B 2 71  PHE 71  70  70  PHE PHE B . n 
B 2 72  THR 72  71  71  THR THR B . n 
B 2 73  PRO 73  72  72  PRO PRO B . n 
B 2 74  THR 74  73  73  THR THR B . n 
B 2 75  GLU 75  74  74  GLU GLU B . n 
B 2 76  LYS 76  75  75  LYS LYS B . n 
B 2 77  ASP 77  76  76  ASP ASP B . n 
B 2 78  GLU 78  77  77  GLU GLU B . n 
B 2 79  TYR 79  78  78  TYR TYR B . n 
B 2 80  ALA 80  79  79  ALA ALA B . n 
B 2 81  CYS 81  80  80  CYS CYS B . n 
B 2 82  ARG 82  81  81  ARG ARG B . n 
B 2 83  VAL 83  82  82  VAL VAL B . n 
B 2 84  ASN 84  83  83  ASN ASN B . n 
B 2 85  HIS 85  84  84  HIS HIS B . n 
B 2 86  VAL 86  85  85  VAL VAL B . n 
B 2 87  THR 87  86  86  THR THR B . n 
B 2 88  LEU 88  87  87  LEU LEU B . n 
B 2 89  SER 89  88  88  SER SER B . n 
B 2 90  GLN 90  89  89  GLN GLN B . n 
B 2 91  PRO 91  90  90  PRO PRO B . n 
B 2 92  LYS 92  91  91  LYS LYS B . n 
B 2 93  ILE 93  92  92  ILE ILE B . n 
B 2 94  VAL 94  93  93  VAL VAL B . n 
B 2 95  LYS 95  94  94  LYS LYS B . n 
B 2 96  TRP 96  95  95  TRP TRP B . n 
B 2 97  ASP 97  96  96  ASP ASP B . n 
B 2 98  ARG 98  97  97  ARG ARG B . n 
B 2 99  ASP 99  98  98  ASP ASP B . n 
B 2 100 MET 100 99  99  MET MET B . n 
C 3 1   ASN 1   1   1   ASN ASN E . n 
C 3 2   TYR 2   2   2   TYR TYR E . n 
C 3 3   ASN 3   3   3   ASN ASN E . n 
C 3 4   TYR 4   4   4   TYR TYR E . n 
C 3 5   LEU 5   5   5   LEU LEU E . n 
C 3 6   TYR 6   6   6   TYR TYR E . n 
C 3 7   ARG 7   7   7   ARG ARG E . n 
C 3 8   LEU 8   8   8   LEU LEU E . n 
C 3 9   PHE 9   9   9   PHE PHE E . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 HOH 1   301 192 HOH HOH A . 
D 4 HOH 2   302 276 HOH HOH A . 
D 4 HOH 3   303 117 HOH HOH A . 
D 4 HOH 4   304 145 HOH HOH A . 
D 4 HOH 5   305 155 HOH HOH A . 
D 4 HOH 6   306 178 HOH HOH A . 
D 4 HOH 7   307 25  HOH HOH A . 
D 4 HOH 8   308 201 HOH HOH A . 
D 4 HOH 9   309 97  HOH HOH A . 
D 4 HOH 10  310 262 HOH HOH A . 
D 4 HOH 11  311 50  HOH HOH A . 
D 4 HOH 12  312 18  HOH HOH A . 
D 4 HOH 13  313 217 HOH HOH A . 
D 4 HOH 14  314 113 HOH HOH A . 
D 4 HOH 15  315 225 HOH HOH A . 
D 4 HOH 16  316 43  HOH HOH A . 
D 4 HOH 17  317 111 HOH HOH A . 
D 4 HOH 18  318 257 HOH HOH A . 
D 4 HOH 19  319 223 HOH HOH A . 
D 4 HOH 20  320 277 HOH HOH A . 
D 4 HOH 21  321 172 HOH HOH A . 
D 4 HOH 22  322 28  HOH HOH A . 
D 4 HOH 23  323 63  HOH HOH A . 
D 4 HOH 24  324 137 HOH HOH A . 
D 4 HOH 25  325 74  HOH HOH A . 
D 4 HOH 26  326 37  HOH HOH A . 
D 4 HOH 27  327 29  HOH HOH A . 
D 4 HOH 28  328 1   HOH HOH A . 
D 4 HOH 29  329 14  HOH HOH A . 
D 4 HOH 30  330 263 HOH HOH A . 
D 4 HOH 31  331 246 HOH HOH A . 
D 4 HOH 32  332 84  HOH HOH A . 
D 4 HOH 33  333 141 HOH HOH A . 
D 4 HOH 34  334 105 HOH HOH A . 
D 4 HOH 35  335 12  HOH HOH A . 
D 4 HOH 36  336 79  HOH HOH A . 
D 4 HOH 37  337 273 HOH HOH A . 
D 4 HOH 38  338 101 HOH HOH A . 
D 4 HOH 39  339 87  HOH HOH A . 
D 4 HOH 40  340 116 HOH HOH A . 
D 4 HOH 41  341 72  HOH HOH A . 
D 4 HOH 42  342 33  HOH HOH A . 
D 4 HOH 43  343 242 HOH HOH A . 
D 4 HOH 44  344 130 HOH HOH A . 
D 4 HOH 45  345 35  HOH HOH A . 
D 4 HOH 46  346 144 HOH HOH A . 
D 4 HOH 47  347 253 HOH HOH A . 
D 4 HOH 48  348 21  HOH HOH A . 
D 4 HOH 49  349 16  HOH HOH A . 
D 4 HOH 50  350 49  HOH HOH A . 
D 4 HOH 51  351 231 HOH HOH A . 
D 4 HOH 52  352 45  HOH HOH A . 
D 4 HOH 53  353 260 HOH HOH A . 
D 4 HOH 54  354 239 HOH HOH A . 
D 4 HOH 55  355 42  HOH HOH A . 
D 4 HOH 56  356 75  HOH HOH A . 
D 4 HOH 57  357 175 HOH HOH A . 
D 4 HOH 58  358 8   HOH HOH A . 
D 4 HOH 59  359 272 HOH HOH A . 
D 4 HOH 60  360 206 HOH HOH A . 
D 4 HOH 61  361 54  HOH HOH A . 
D 4 HOH 62  362 5   HOH HOH A . 
D 4 HOH 63  363 268 HOH HOH A . 
D 4 HOH 64  364 210 HOH HOH A . 
D 4 HOH 65  365 161 HOH HOH A . 
D 4 HOH 66  366 88  HOH HOH A . 
D 4 HOH 67  367 163 HOH HOH A . 
D 4 HOH 68  368 26  HOH HOH A . 
D 4 HOH 69  369 76  HOH HOH A . 
D 4 HOH 70  370 3   HOH HOH A . 
D 4 HOH 71  371 56  HOH HOH A . 
D 4 HOH 72  372 212 HOH HOH A . 
D 4 HOH 73  373 24  HOH HOH A . 
D 4 HOH 74  374 91  HOH HOH A . 
D 4 HOH 75  375 241 HOH HOH A . 
D 4 HOH 76  376 80  HOH HOH A . 
D 4 HOH 77  377 119 HOH HOH A . 
D 4 HOH 78  378 131 HOH HOH A . 
D 4 HOH 79  379 136 HOH HOH A . 
D 4 HOH 80  380 109 HOH HOH A . 
D 4 HOH 81  381 190 HOH HOH A . 
D 4 HOH 82  382 216 HOH HOH A . 
D 4 HOH 83  383 127 HOH HOH A . 
D 4 HOH 84  384 202 HOH HOH A . 
D 4 HOH 85  385 207 HOH HOH A . 
D 4 HOH 86  386 153 HOH HOH A . 
D 4 HOH 87  387 200 HOH HOH A . 
D 4 HOH 88  388 199 HOH HOH A . 
D 4 HOH 89  389 270 HOH HOH A . 
D 4 HOH 90  390 53  HOH HOH A . 
D 4 HOH 91  391 174 HOH HOH A . 
D 4 HOH 92  392 135 HOH HOH A . 
D 4 HOH 93  393 271 HOH HOH A . 
D 4 HOH 94  394 164 HOH HOH A . 
D 4 HOH 95  395 235 HOH HOH A . 
D 4 HOH 96  396 134 HOH HOH A . 
D 4 HOH 97  397 6   HOH HOH A . 
D 4 HOH 98  398 115 HOH HOH A . 
D 4 HOH 99  399 39  HOH HOH A . 
D 4 HOH 100 400 70  HOH HOH A . 
D 4 HOH 101 401 85  HOH HOH A . 
D 4 HOH 102 402 112 HOH HOH A . 
D 4 HOH 103 403 20  HOH HOH A . 
D 4 HOH 104 404 4   HOH HOH A . 
D 4 HOH 105 405 215 HOH HOH A . 
D 4 HOH 106 406 95  HOH HOH A . 
D 4 HOH 107 407 226 HOH HOH A . 
D 4 HOH 108 408 89  HOH HOH A . 
D 4 HOH 109 409 252 HOH HOH A . 
D 4 HOH 110 410 36  HOH HOH A . 
D 4 HOH 111 411 274 HOH HOH A . 
D 4 HOH 112 412 103 HOH HOH A . 
D 4 HOH 113 413 126 HOH HOH A . 
D 4 HOH 114 414 197 HOH HOH A . 
D 4 HOH 115 415 148 HOH HOH A . 
D 4 HOH 116 416 133 HOH HOH A . 
D 4 HOH 117 417 238 HOH HOH A . 
D 4 HOH 118 418 99  HOH HOH A . 
D 4 HOH 119 419 156 HOH HOH A . 
D 4 HOH 120 420 38  HOH HOH A . 
D 4 HOH 121 421 176 HOH HOH A . 
D 4 HOH 122 422 90  HOH HOH A . 
D 4 HOH 123 423 208 HOH HOH A . 
D 4 HOH 124 424 196 HOH HOH A . 
D 4 HOH 125 425 233 HOH HOH A . 
D 4 HOH 126 426 181 HOH HOH A . 
D 4 HOH 127 427 47  HOH HOH A . 
D 4 HOH 128 428 100 HOH HOH A . 
D 4 HOH 129 429 120 HOH HOH A . 
D 4 HOH 130 430 104 HOH HOH A . 
D 4 HOH 131 431 157 HOH HOH A . 
D 4 HOH 132 432 69  HOH HOH A . 
D 4 HOH 133 433 73  HOH HOH A . 
D 4 HOH 134 434 132 HOH HOH A . 
D 4 HOH 135 435 129 HOH HOH A . 
D 4 HOH 136 436 121 HOH HOH A . 
D 4 HOH 137 437 219 HOH HOH A . 
D 4 HOH 138 438 96  HOH HOH A . 
D 4 HOH 139 439 149 HOH HOH A . 
D 4 HOH 140 440 177 HOH HOH A . 
D 4 HOH 141 441 158 HOH HOH A . 
D 4 HOH 142 442 165 HOH HOH A . 
D 4 HOH 143 443 151 HOH HOH A . 
D 4 HOH 144 444 114 HOH HOH A . 
D 4 HOH 145 445 256 HOH HOH A . 
D 4 HOH 146 446 259 HOH HOH A . 
D 4 HOH 147 447 102 HOH HOH A . 
D 4 HOH 148 448 44  HOH HOH A . 
D 4 HOH 149 449 162 HOH HOH A . 
D 4 HOH 150 450 255 HOH HOH A . 
D 4 HOH 151 451 264 HOH HOH A . 
D 4 HOH 152 452 194 HOH HOH A . 
D 4 HOH 153 453 267 HOH HOH A . 
D 4 HOH 154 454 224 HOH HOH A . 
D 4 HOH 155 455 143 HOH HOH A . 
D 4 HOH 156 456 193 HOH HOH A . 
D 4 HOH 157 457 83  HOH HOH A . 
D 4 HOH 158 458 48  HOH HOH A . 
D 4 HOH 159 459 228 HOH HOH A . 
D 4 HOH 160 460 154 HOH HOH A . 
D 4 HOH 161 461 211 HOH HOH A . 
D 4 HOH 162 462 186 HOH HOH A . 
D 4 HOH 163 463 261 HOH HOH A . 
D 4 HOH 164 464 205 HOH HOH A . 
D 4 HOH 165 465 122 HOH HOH A . 
D 4 HOH 166 466 275 HOH HOH A . 
D 4 HOH 167 467 171 HOH HOH A . 
D 4 HOH 168 468 187 HOH HOH A . 
D 4 HOH 169 469 195 HOH HOH A . 
D 4 HOH 170 470 229 HOH HOH A . 
D 4 HOH 171 471 110 HOH HOH A . 
D 4 HOH 172 472 183 HOH HOH A . 
D 4 HOH 173 473 189 HOH HOH A . 
D 4 HOH 174 474 232 HOH HOH A . 
D 4 HOH 175 475 166 HOH HOH A . 
D 4 HOH 176 476 184 HOH HOH A . 
E 4 HOH 1   101 140 HOH HOH B . 
E 4 HOH 2   102 222 HOH HOH B . 
E 4 HOH 3   103 245 HOH HOH B . 
E 4 HOH 4   104 230 HOH HOH B . 
E 4 HOH 5   105 278 HOH HOH B . 
E 4 HOH 6   106 243 HOH HOH B . 
E 4 HOH 7   107 41  HOH HOH B . 
E 4 HOH 8   108 30  HOH HOH B . 
E 4 HOH 9   109 146 HOH HOH B . 
E 4 HOH 10  110 59  HOH HOH B . 
E 4 HOH 11  111 138 HOH HOH B . 
E 4 HOH 12  112 279 HOH HOH B . 
E 4 HOH 13  113 10  HOH HOH B . 
E 4 HOH 14  114 179 HOH HOH B . 
E 4 HOH 15  115 19  HOH HOH B . 
E 4 HOH 16  116 40  HOH HOH B . 
E 4 HOH 17  117 27  HOH HOH B . 
E 4 HOH 18  118 107 HOH HOH B . 
E 4 HOH 19  119 46  HOH HOH B . 
E 4 HOH 20  120 57  HOH HOH B . 
E 4 HOH 21  121 2   HOH HOH B . 
E 4 HOH 22  122 15  HOH HOH B . 
E 4 HOH 23  123 180 HOH HOH B . 
E 4 HOH 24  124 118 HOH HOH B . 
E 4 HOH 25  125 106 HOH HOH B . 
E 4 HOH 26  126 147 HOH HOH B . 
E 4 HOH 27  127 9   HOH HOH B . 
E 4 HOH 28  128 58  HOH HOH B . 
E 4 HOH 29  129 203 HOH HOH B . 
E 4 HOH 30  130 86  HOH HOH B . 
E 4 HOH 31  131 150 HOH HOH B . 
E 4 HOH 32  132 31  HOH HOH B . 
E 4 HOH 33  133 169 HOH HOH B . 
E 4 HOH 34  134 78  HOH HOH B . 
E 4 HOH 35  135 124 HOH HOH B . 
E 4 HOH 36  136 55  HOH HOH B . 
E 4 HOH 37  137 93  HOH HOH B . 
E 4 HOH 38  138 142 HOH HOH B . 
E 4 HOH 39  139 51  HOH HOH B . 
E 4 HOH 40  140 123 HOH HOH B . 
E 4 HOH 41  141 60  HOH HOH B . 
E 4 HOH 42  142 221 HOH HOH B . 
E 4 HOH 43  143 198 HOH HOH B . 
E 4 HOH 44  144 220 HOH HOH B . 
E 4 HOH 45  145 191 HOH HOH B . 
E 4 HOH 46  146 66  HOH HOH B . 
E 4 HOH 47  147 22  HOH HOH B . 
E 4 HOH 48  148 71  HOH HOH B . 
E 4 HOH 49  149 159 HOH HOH B . 
E 4 HOH 50  150 139 HOH HOH B . 
E 4 HOH 51  151 13  HOH HOH B . 
E 4 HOH 52  152 204 HOH HOH B . 
E 4 HOH 53  153 247 HOH HOH B . 
E 4 HOH 54  154 236 HOH HOH B . 
E 4 HOH 55  155 94  HOH HOH B . 
E 4 HOH 56  156 218 HOH HOH B . 
E 4 HOH 57  157 98  HOH HOH B . 
E 4 HOH 58  158 68  HOH HOH B . 
E 4 HOH 59  159 168 HOH HOH B . 
E 4 HOH 60  160 167 HOH HOH B . 
E 4 HOH 61  161 92  HOH HOH B . 
E 4 HOH 62  162 266 HOH HOH B . 
E 4 HOH 63  163 209 HOH HOH B . 
E 4 HOH 64  164 173 HOH HOH B . 
E 4 HOH 65  165 214 HOH HOH B . 
E 4 HOH 66  166 258 HOH HOH B . 
E 4 HOH 67  167 170 HOH HOH B . 
E 4 HOH 68  168 248 HOH HOH B . 
E 4 HOH 69  169 182 HOH HOH B . 
E 4 HOH 70  170 160 HOH HOH B . 
E 4 HOH 71  171 125 HOH HOH B . 
E 4 HOH 72  172 62  HOH HOH B . 
E 4 HOH 73  173 237 HOH HOH B . 
E 4 HOH 74  174 250 HOH HOH B . 
E 4 HOH 75  175 234 HOH HOH B . 
E 4 HOH 76  176 227 HOH HOH B . 
E 4 HOH 77  177 108 HOH HOH B . 
E 4 HOH 78  178 240 HOH HOH B . 
E 4 HOH 79  179 254 HOH HOH B . 
E 4 HOH 80  180 265 HOH HOH B . 
E 4 HOH 81  181 249 HOH HOH B . 
F 4 HOH 1   101 81  HOH HOH E . 
F 4 HOH 2   102 32  HOH HOH E . 
F 4 HOH 3   103 251 HOH HOH E . 
F 4 HOH 4   104 185 HOH HOH E . 
F 4 HOH 5   105 7   HOH HOH E . 
F 4 HOH 6   106 82  HOH HOH E . 
F 4 HOH 7   107 67  HOH HOH E . 
F 4 HOH 8   108 52  HOH HOH E . 
F 4 HOH 9   109 11  HOH HOH E . 
F 4 HOH 10  110 17  HOH HOH E . 
F 4 HOH 11  111 65  HOH HOH E . 
F 4 HOH 12  112 244 HOH HOH E . 
F 4 HOH 13  113 269 HOH HOH E . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.20.1_4487: ???)' 1 
? phasing    ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .                    2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.44 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YZZ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     161.859 
_cell.length_a_esd                 ? 
_cell.length_b                     65.686 
_cell.length_b_esd                 ? 
_cell.length_c                     50.090 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YZZ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YZZ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.98 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          58.70 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Sodium citrate tribasic dihydrate ,18%w/v Polyethylene glycol 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9792 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9792 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          18.02 
_reflns.entry_id                                       8YZZ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.88 
_reflns.d_resolution_low                               80.93 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     42782 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.600 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.110 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.88 
_reflns_shell.d_res_low                                     1.98 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.3 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6179 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               4.3 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.752 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.3 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YZZ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.88 
_refine.ls_d_res_low                             42.45 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     42614 
_refine.ls_number_reflns_R_free                  2095 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.37 
_refine.ls_percent_reflns_R_free                 4.92 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1907 
_refine.ls_R_factor_R_free                       0.2242 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1889 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      7F4W 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.72 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.19 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.88 
_refine_hist.d_res_low                        42.45 
_refine_hist.number_atoms_solvent             270 
_refine_hist.number_atoms_total               3419 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3149 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007 ? 3234 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.021 ? 4380 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 6.470 ? 433  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.067 ? 442  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.011 ? 577  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.88 1.92  . . 132 2625 97.00  . . . . 0.2668 . . . . . . . . . . . 0.3098 
'X-RAY DIFFRACTION' 1.92 1.97  . . 120 2633 98.00  . . . . 0.2397 . . . . . . . . . . . 0.2730 
'X-RAY DIFFRACTION' 1.97 2.02  . . 127 2686 98.00  . . . . 0.2221 . . . . . . . . . . . 0.2392 
'X-RAY DIFFRACTION' 2.02 2.08  . . 142 2679 99.00  . . . . 0.2177 . . . . . . . . . . . 0.2900 
'X-RAY DIFFRACTION' 2.08 2.15  . . 111 2693 99.00  . . . . 0.2072 . . . . . . . . . . . 0.2403 
'X-RAY DIFFRACTION' 2.15 2.23  . . 146 2702 100.00 . . . . 0.1994 . . . . . . . . . . . 0.2521 
'X-RAY DIFFRACTION' 2.23 2.32  . . 128 2718 100.00 . . . . 0.1984 . . . . . . . . . . . 0.2566 
'X-RAY DIFFRACTION' 2.32 2.42  . . 141 2718 100.00 . . . . 0.1982 . . . . . . . . . . . 0.2521 
'X-RAY DIFFRACTION' 2.42 2.55  . . 165 2654 100.00 . . . . 0.2034 . . . . . . . . . . . 0.2422 
'X-RAY DIFFRACTION' 2.55 2.71  . . 154 2717 100.00 . . . . 0.1980 . . . . . . . . . . . 0.2410 
'X-RAY DIFFRACTION' 2.71 2.92  . . 145 2714 100.00 . . . . 0.2078 . . . . . . . . . . . 0.2405 
'X-RAY DIFFRACTION' 2.92 3.21  . . 142 2714 100.00 . . . . 0.1893 . . . . . . . . . . . 0.1986 
'X-RAY DIFFRACTION' 3.21 3.68  . . 144 2721 100.00 . . . . 0.1796 . . . . . . . . . . . 0.2041 
'X-RAY DIFFRACTION' 3.68 4.63  . . 127 2774 100.00 . . . . 0.1469 . . . . . . . . . . . 0.1881 
'X-RAY DIFFRACTION' 4.63 42.45 . . 171 2771 100.00 . . . . 0.1630 . . . . . . . . . . . 0.1865 
# 
_struct.entry_id                     8YZZ 
_struct.title                        
'The structure of HLA-A*2402 complex with peptide from SARS-CoV-2 S448-456 NYNYLYRLF(Prototype)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YZZ 
_struct_keywords.text            'Complex, Peptide presentation, Immune system' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP A0A143Y4R2_HUMAN A0A143Y4R2 ? 1 
;GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDEETGKVKAHSQTDRENLRI
ALRYYNQSEAGSHTLQMMFGCDVGSDGRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQITKRKWEAAHVAEQQRAYL
EGTCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW
;
25  
2 UNP B2MG_HUMAN       P61769     ? 2 
;IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM
;
21  
3 UNP SPIKE_SARS2      P0DTC2     ? 3 NYNYLYRLF 448 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YZZ A 1 ? 274 ? A0A143Y4R2 25  ? 298 ? 1 274 
2 2 8YZZ B 2 ? 100 ? P61769     21  ? 119 ? 1 99  
3 3 8YZZ E 1 ? 9   ? P0DTC2     448 ? 456 ? 1 9   
# 
_struct_ref_seq_dif.align_id                     2 
_struct_ref_seq_dif.pdbx_pdb_id_code             8YZZ 
_struct_ref_seq_dif.mon_id                       MET 
_struct_ref_seq_dif.pdbx_pdb_strand_id           B 
_struct_ref_seq_dif.seq_num                      1 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P61769 
_struct_ref_seq_dif.db_mon_id                    ? 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          ? 
_struct_ref_seq_dif.details                      'initiating methionine' 
_struct_ref_seq_dif.pdbx_auth_seq_num            0 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4710  ? 
1 MORE         -19   ? 
1 'SSA (A^2)'  18690 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ALA A 49  ? GLU A 55  ? ALA A 49  GLU A 55  5 ? 7  
HELX_P HELX_P2 AA2 GLY A 56  ? TYR A 85  ? GLY A 56  TYR A 85  1 ? 30 
HELX_P HELX_P3 AA3 ASP A 137 ? ALA A 150 ? ASP A 137 ALA A 150 1 ? 14 
HELX_P HELX_P4 AA4 HIS A 151 ? GLN A 156 ? HIS A 151 GLN A 156 1 ? 6  
HELX_P HELX_P5 AA5 GLN A 156 ? GLY A 162 ? GLN A 156 GLY A 162 1 ? 7  
HELX_P HELX_P6 AA6 GLY A 162 ? GLY A 175 ? GLY A 162 GLY A 175 1 ? 14 
HELX_P HELX_P7 AA7 GLY A 175 ? GLN A 180 ? GLY A 175 GLN A 180 1 ? 6  
HELX_P HELX_P8 AA8 THR A 225 ? THR A 228 ? THR A 225 THR A 228 5 ? 4  
HELX_P HELX_P9 AA9 GLU A 253 ? GLN A 255 ? GLU A 253 GLN A 255 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 101 SG ? ? ? 1_555 A CYS 164 SG ? ? A CYS 101 A CYS 164 1_555 ? ? ? ? ? ? ? 2.096 ? ? 
disulf2 disulf ? ? A CYS 203 SG ? ? ? 1_555 A CYS 259 SG ? ? A CYS 203 A CYS 259 1_555 ? ? ? ? ? ? ? 2.048 ? ? 
disulf3 disulf ? ? B CYS 26  SG ? ? ? 1_555 B CYS 81  SG ? ? B CYS 25  B CYS 80  1_555 ? ? ? ? ? ? ? 2.039 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 101 ? CYS A 164 ? CYS A 101 ? 1_555 CYS A 164 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 203 ? CYS A 259 ? CYS A 203 ? 1_555 CYS A 259 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 26  ? CYS B 81  ? CYS B 25  ? 1_555 CYS B 80  ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 TYR 209 A . ? TYR 209 A PRO 210 A ? PRO 210 A 1 -0.44 
2 HIS 32  B . ? HIS 31  B PRO 33  B ? PRO 32  B 1 4.73  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 46  ? PRO A 47  ? GLU A 46  PRO A 47  
AA1 2 THR A 31  ? ASP A 37  ? THR A 31  ASP A 37  
AA1 3 ARG A 21  ? VAL A 28  ? ARG A 21  VAL A 28  
AA1 4 HIS A 3   ? VAL A 12  ? HIS A 3   VAL A 12  
AA1 5 THR A 94  ? VAL A 103 ? THR A 94  VAL A 103 
AA1 6 PHE A 109 ? TYR A 118 ? PHE A 109 TYR A 118 
AA1 7 LYS A 121 ? LEU A 126 ? LYS A 121 LEU A 126 
AA1 8 TRP A 133 ? ALA A 135 ? TRP A 133 ALA A 135 
AA2 1 LYS A 186 ? PRO A 193 ? LYS A 186 PRO A 193 
AA2 2 GLU A 198 ? PHE A 208 ? GLU A 198 PHE A 208 
AA2 3 PHE A 241 ? PRO A 250 ? PHE A 241 PRO A 250 
AA2 4 GLU A 229 ? LEU A 230 ? GLU A 229 LEU A 230 
AA3 1 LYS A 186 ? PRO A 193 ? LYS A 186 PRO A 193 
AA3 2 GLU A 198 ? PHE A 208 ? GLU A 198 PHE A 208 
AA3 3 PHE A 241 ? PRO A 250 ? PHE A 241 PRO A 250 
AA3 4 ARG A 234 ? PRO A 235 ? ARG A 234 PRO A 235 
AA4 1 GLU A 222 ? ASP A 223 ? GLU A 222 ASP A 223 
AA4 2 THR A 214 ? ARG A 219 ? THR A 214 ARG A 219 
AA4 3 TYR A 257 ? GLN A 262 ? TYR A 257 GLN A 262 
AA4 4 LEU A 270 ? LEU A 272 ? LEU A 270 LEU A 272 
AA5 1 LYS B 7   ? SER B 12  ? LYS B 6   SER B 11  
AA5 2 ASN B 22  ? PHE B 31  ? ASN B 21  PHE B 30  
AA5 3 PHE B 63  ? PHE B 71  ? PHE B 62  PHE B 70  
AA5 4 GLU B 51  ? HIS B 52  ? GLU B 50  HIS B 51  
AA6 1 LYS B 7   ? SER B 12  ? LYS B 6   SER B 11  
AA6 2 ASN B 22  ? PHE B 31  ? ASN B 21  PHE B 30  
AA6 3 PHE B 63  ? PHE B 71  ? PHE B 62  PHE B 70  
AA6 4 SER B 56  ? PHE B 57  ? SER B 55  PHE B 56  
AA7 1 GLU B 45  ? ARG B 46  ? GLU B 44  ARG B 45  
AA7 2 GLU B 37  ? LYS B 42  ? GLU B 36  LYS B 41  
AA7 3 TYR B 79  ? ASN B 84  ? TYR B 78  ASN B 83  
AA7 4 LYS B 92  ? LYS B 95  ? LYS B 91  LYS B 94  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLU A 46  ? O GLU A 46  N ARG A 35  ? N ARG A 35  
AA1 2 3 O PHE A 33  ? O PHE A 33  N GLY A 26  ? N GLY A 26  
AA1 3 4 O TYR A 27  ? O TYR A 27  N ARG A 6   ? N ARG A 6   
AA1 4 5 N HIS A 3   ? N HIS A 3   O VAL A 103 ? O VAL A 103 
AA1 5 6 N GLN A 96  ? N GLN A 96  O ALA A 117 ? O ALA A 117 
AA1 6 7 N TYR A 116 ? N TYR A 116 O ILE A 124 ? O ILE A 124 
AA1 7 8 N ALA A 125 ? N ALA A 125 O THR A 134 ? O THR A 134 
AA2 1 2 N HIS A 192 ? N HIS A 192 O THR A 200 ? O THR A 200 
AA2 2 3 N CYS A 203 ? N CYS A 203 O ALA A 245 ? O ALA A 245 
AA2 3 4 O ALA A 246 ? O ALA A 246 N GLU A 229 ? N GLU A 229 
AA3 1 2 N HIS A 192 ? N HIS A 192 O THR A 200 ? O THR A 200 
AA3 2 3 N CYS A 203 ? N CYS A 203 O ALA A 245 ? O ALA A 245 
AA3 3 4 O GLN A 242 ? O GLN A 242 N ARG A 234 ? N ARG A 234 
AA4 1 2 O GLU A 222 ? O GLU A 222 N ARG A 219 ? N ARG A 219 
AA4 2 3 N THR A 216 ? N THR A 216 O HIS A 260 ? O HIS A 260 
AA4 3 4 N CYS A 259 ? N CYS A 259 O LEU A 272 ? O LEU A 272 
AA5 1 2 N TYR B 11  ? N TYR B 10  O ASN B 25  ? O ASN B 24  
AA5 2 3 N LEU B 24  ? N LEU B 23  O THR B 69  ? O THR B 68  
AA5 3 4 O TYR B 68  ? O TYR B 67  N GLU B 51  ? N GLU B 50  
AA6 1 2 N TYR B 11  ? N TYR B 10  O ASN B 25  ? O ASN B 24  
AA6 2 3 N LEU B 24  ? N LEU B 23  O THR B 69  ? O THR B 68  
AA6 3 4 O TYR B 64  ? O TYR B 63  N SER B 56  ? N SER B 55  
AA7 1 2 O GLU B 45  ? O GLU B 44  N LYS B 42  ? N LYS B 41  
AA7 2 3 N LEU B 41  ? N LEU B 40  O ALA B 80  ? O ALA B 79  
AA7 3 4 N VAL B 83  ? N VAL B 82  O LYS B 92  ? O LYS B 91  
# 
_pdbx_entry_details.entry_id                   8YZZ 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 29  ? ? 56.66   -122.46 
2 1 HIS A 114 ? ? -164.28 91.90   
3 1 TYR A 123 ? ? -112.85 -74.02  
4 1 GLN A 224 ? ? -103.12 54.73   
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     398 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   D 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7F4W 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YZZ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.006178 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000047 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015224 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019965 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLY A 1 1   ? -18.691 -12.781 24.076  1.00 42.10 ? 1   GLY A N   1 
ATOM   2    C CA  . GLY A 1 1   ? -17.396 -12.625 24.720  1.00 31.72 ? 1   GLY A CA  1 
ATOM   3    C C   . GLY A 1 1   ? -16.558 -13.887 24.664  1.00 31.04 ? 1   GLY A C   1 
ATOM   4    O O   . GLY A 1 1   ? -15.366 -13.834 24.355  1.00 33.65 ? 1   GLY A O   1 
ATOM   5    N N   . SER A 1 2   ? -17.176 -15.025 24.967  1.00 25.61 ? 2   SER A N   1 
ATOM   6    C CA  . SER A 1 2   ? -16.482 -16.302 24.931  1.00 28.03 ? 2   SER A CA  1 
ATOM   7    C C   . SER A 1 2   ? -16.466 -16.875 23.510  1.00 23.78 ? 2   SER A C   1 
ATOM   8    O O   . SER A 1 2   ? -17.264 -16.499 22.652  1.00 20.62 ? 2   SER A O   1 
ATOM   9    C CB  . SER A 1 2   ? -17.133 -17.283 25.899  1.00 24.13 ? 2   SER A CB  1 
ATOM   10   O OG  . SER A 1 2   ? -18.387 -17.700 25.412  1.00 32.67 ? 2   SER A OG  1 
ATOM   11   N N   . HIS A 1 3   ? -15.530 -17.790 23.270  1.00 20.36 ? 3   HIS A N   1 
ATOM   12   C CA  . HIS A 1 3   ? -15.337 -18.358 21.945  1.00 18.36 ? 3   HIS A CA  1 
ATOM   13   C C   . HIS A 1 3   ? -15.043 -19.841 22.061  1.00 19.99 ? 3   HIS A C   1 
ATOM   14   O O   . HIS A 1 3   ? -14.664 -20.342 23.124  1.00 17.60 ? 3   HIS A O   1 
ATOM   15   C CB  . HIS A 1 3   ? -14.202 -17.673 21.194  1.00 15.66 ? 3   HIS A CB  1 
ATOM   16   C CG  . HIS A 1 3   ? -14.423 -16.216 20.994  1.00 19.31 ? 3   HIS A CG  1 
ATOM   17   N ND1 . HIS A 1 3   ? -15.244 -15.723 20.003  1.00 20.42 ? 3   HIS A ND1 1 
ATOM   18   C CD2 . HIS A 1 3   ? -13.981 -15.145 21.691  1.00 20.06 ? 3   HIS A CD2 1 
ATOM   19   C CE1 . HIS A 1 3   ? -15.272 -14.404 20.080  1.00 25.75 ? 3   HIS A CE1 1 
ATOM   20   N NE2 . HIS A 1 3   ? -14.513 -14.028 21.095  1.00 21.67 ? 3   HIS A NE2 1 
ATOM   21   N N   . SER A 1 4   ? -15.220 -20.539 20.945  1.00 14.82 ? 4   SER A N   1 
ATOM   22   C CA  . SER A 1 4   ? -15.035 -21.978 20.905  1.00 15.37 ? 4   SER A CA  1 
ATOM   23   C C   . SER A 1 4   ? -14.187 -22.352 19.691  1.00 15.74 ? 4   SER A C   1 
ATOM   24   O O   . SER A 1 4   ? -14.156 -21.635 18.680  1.00 17.51 ? 4   SER A O   1 
ATOM   25   C CB  . SER A 1 4   ? -16.377 -22.711 20.854  1.00 17.73 ? 4   SER A CB  1 
ATOM   26   O OG  . SER A 1 4   ? -17.028 -22.462 19.620  1.00 20.93 ? 4   SER A OG  1 
ATOM   27   N N   . MET A 1 5   ? -13.511 -23.486 19.795  1.00 9.77  ? 5   MET A N   1 
ATOM   28   C CA  . MET A 1 5   ? -12.908 -24.115 18.627  1.00 12.40 ? 5   MET A CA  1 
ATOM   29   C C   . MET A 1 5   ? -13.305 -25.578 18.642  1.00 14.68 ? 5   MET A C   1 
ATOM   30   O O   . MET A 1 5   ? -13.229 -26.233 19.682  1.00 14.40 ? 5   MET A O   1 
ATOM   31   C CB  . MET A 1 5   ? -11.383 -23.953 18.584  1.00 16.99 ? 5   MET A CB  1 
ATOM   32   C CG  . MET A 1 5   ? -10.786 -24.618 17.340  1.00 15.41 ? 5   MET A CG  1 
ATOM   33   S SD  . MET A 1 5   ? -9.076  -24.147 17.029  1.00 20.10 ? 5   MET A SD  1 
ATOM   34   C CE  . MET A 1 5   ? -8.182  -24.758 18.476  1.00 20.80 ? 5   MET A CE  1 
ATOM   35   N N   . ARG A 1 6   ? -13.784 -26.076 17.510  1.00 11.17 ? 6   ARG A N   1 
ATOM   36   C CA  . ARG A 1 6   ? -14.180 -27.466 17.447  1.00 10.79 ? 6   ARG A CA  1 
ATOM   37   C C   . ARG A 1 6   ? -13.686 -28.095 16.159  1.00 12.36 ? 6   ARG A C   1 
ATOM   38   O O   . ARG A 1 6   ? -13.729 -27.483 15.090  1.00 13.76 ? 6   ARG A O   1 
ATOM   39   C CB  . ARG A 1 6   ? -15.694 -27.636 17.525  1.00 14.35 ? 6   ARG A CB  1 
ATOM   40   C CG  . ARG A 1 6   ? -16.338 -26.990 18.734  1.00 14.61 ? 6   ARG A CG  1 
ATOM   41   C CD  . ARG A 1 6   ? -16.604 -28.030 19.813  1.00 21.76 ? 6   ARG A CD  1 
ATOM   42   N NE  . ARG A 1 6   ? -17.428 -27.502 20.894  1.00 19.46 ? 6   ARG A NE  1 
ATOM   43   C CZ  . ARG A 1 6   ? -17.042 -26.579 21.765  1.00 22.11 ? 6   ARG A CZ  1 
ATOM   44   N NH1 . ARG A 1 6   ? -15.805 -26.110 21.776  1.00 16.07 ? 6   ARG A NH1 1 
ATOM   45   N NH2 . ARG A 1 6   ? -17.926 -26.104 22.639  1.00 19.66 ? 6   ARG A NH2 1 
ATOM   46   N N   . TYR A 1 7   ? -13.290 -29.347 16.276  1.00 10.18 ? 7   TYR A N   1 
ATOM   47   C CA  . TYR A 1 7   ? -13.060 -30.217 15.146  1.00 9.64  ? 7   TYR A CA  1 
ATOM   48   C C   . TYR A 1 7   ? -14.112 -31.315 15.194  1.00 14.13 ? 7   TYR A C   1 
ATOM   49   O O   . TYR A 1 7   ? -14.391 -31.867 16.264  1.00 12.74 ? 7   TYR A O   1 
ATOM   50   C CB  . TYR A 1 7   ? -11.650 -30.795 15.204  1.00 12.31 ? 7   TYR A CB  1 
ATOM   51   C CG  . TYR A 1 7   ? -10.593 -29.774 14.874  1.00 14.06 ? 7   TYR A CG  1 
ATOM   52   C CD1 . TYR A 1 7   ? -10.325 -29.427 13.547  1.00 12.74 ? 7   TYR A CD1 1 
ATOM   53   C CD2 . TYR A 1 7   ? -9.869  -29.138 15.885  1.00 14.30 ? 7   TYR A CD2 1 
ATOM   54   C CE1 . TYR A 1 7   ? -9.349  -28.487 13.242  1.00 13.19 ? 7   TYR A CE1 1 
ATOM   55   C CE2 . TYR A 1 7   ? -8.889  -28.203 15.578  1.00 16.52 ? 7   TYR A CE2 1 
ATOM   56   C CZ  . TYR A 1 7   ? -8.636  -27.890 14.256  1.00 17.29 ? 7   TYR A CZ  1 
ATOM   57   O OH  . TYR A 1 7   ? -7.656  -26.965 13.961  1.00 17.78 ? 7   TYR A OH  1 
ATOM   58   N N   . PHE A 1 8   ? -14.715 -31.592 14.043  1.00 11.24 ? 8   PHE A N   1 
ATOM   59   C CA  . PHE A 1 8   ? -15.711 -32.638 13.887  1.00 13.06 ? 8   PHE A CA  1 
ATOM   60   C C   . PHE A 1 8   ? -15.194 -33.633 12.865  1.00 14.18 ? 8   PHE A C   1 
ATOM   61   O O   . PHE A 1 8   ? -14.867 -33.248 11.740  1.00 13.39 ? 8   PHE A O   1 
ATOM   62   C CB  . PHE A 1 8   ? -17.052 -32.053 13.415  1.00 10.73 ? 8   PHE A CB  1 
ATOM   63   C CG  . PHE A 1 8   ? -17.579 -30.959 14.294  1.00 12.28 ? 8   PHE A CG  1 
ATOM   64   C CD1 . PHE A 1 8   ? -18.222 -31.265 15.482  1.00 15.40 ? 8   PHE A CD1 1 
ATOM   65   C CD2 . PHE A 1 8   ? -17.474 -29.630 13.924  1.00 15.78 ? 8   PHE A CD2 1 
ATOM   66   C CE1 . PHE A 1 8   ? -18.709 -30.266 16.312  1.00 14.58 ? 8   PHE A CE1 1 
ATOM   67   C CE2 . PHE A 1 8   ? -17.978 -28.623 14.748  1.00 18.79 ? 8   PHE A CE2 1 
ATOM   68   C CZ  . PHE A 1 8   ? -18.595 -28.946 15.940  1.00 16.49 ? 8   PHE A CZ  1 
ATOM   69   N N   . SER A 1 9   ? -15.139 -34.905 13.239  1.00 11.46 ? 9   SER A N   1 
ATOM   70   C CA  . SER A 1 9   ? -14.682 -35.949 12.332  1.00 12.94 ? 9   SER A CA  1 
ATOM   71   C C   . SER A 1 9   ? -15.732 -37.044 12.186  1.00 12.30 ? 9   SER A C   1 
ATOM   72   O O   . SER A 1 9   ? -16.448 -37.360 13.141  1.00 11.67 ? 9   SER A O   1 
ATOM   73   C CB  . SER A 1 9   ? -13.330 -36.510 12.829  1.00 13.88 ? 9   SER A CB  1 
ATOM   74   O OG  . SER A 1 9   ? -13.527 -37.651 13.656  1.00 17.87 ? 9   SER A OG  1 
ATOM   75   N N   . THR A 1 10  ? -15.852 -37.580 10.967  1.00 12.02 ? 10  THR A N   1 
ATOM   76   C CA  . THR A 1 10  ? -16.778 -38.669 10.647  1.00 13.61 ? 10  THR A CA  1 
ATOM   77   C C   . THR A 1 10  ? -16.025 -39.739 9.863   1.00 14.06 ? 10  THR A C   1 
ATOM   78   O O   . THR A 1 10  ? -15.457 -39.444 8.805   1.00 13.74 ? 10  THR A O   1 
ATOM   79   C CB  . THR A 1 10  ? -17.978 -38.163 9.823   1.00 14.32 ? 10  THR A CB  1 
ATOM   80   O OG1 . THR A 1 10  ? -18.603 -37.044 10.477  1.00 13.81 ? 10  THR A OG1 1 
ATOM   81   C CG2 . THR A 1 10  ? -19.021 -39.278 9.638   1.00 14.40 ? 10  THR A CG2 1 
ATOM   82   N N   . SER A 1 11  ? -16.037 -40.975 10.355  1.00 12.89 ? 11  SER A N   1 
ATOM   83   C CA  . SER A 1 11  ? -15.576 -42.136 9.595   1.00 14.44 ? 11  SER A CA  1 
ATOM   84   C C   . SER A 1 11  ? -16.757 -43.050 9.323   1.00 13.99 ? 11  SER A C   1 
ATOM   85   O O   . SER A 1 11  ? -17.520 -43.361 10.245  1.00 15.26 ? 11  SER A O   1 
ATOM   86   C CB  . SER A 1 11  ? -14.493 -42.924 10.333  1.00 13.84 ? 11  SER A CB  1 
ATOM   87   O OG  . SER A 1 11  ? -13.559 -42.074 10.957  1.00 23.78 ? 11  SER A OG  1 
ATOM   88   N N   . VAL A 1 12  ? -16.910 -43.473 8.067   1.00 15.39 ? 12  VAL A N   1 
ATOM   89   C CA  . VAL A 1 12  ? -18.044 -44.297 7.636   1.00 13.47 ? 12  VAL A CA  1 
ATOM   90   C C   . VAL A 1 12  ? -17.497 -45.520 6.912   1.00 16.23 ? 12  VAL A C   1 
ATOM   91   O O   . VAL A 1 12  ? -16.865 -45.388 5.858   1.00 15.85 ? 12  VAL A O   1 
ATOM   92   C CB  . VAL A 1 12  ? -19.013 -43.519 6.727   1.00 17.92 ? 12  VAL A CB  1 
ATOM   93   C CG1 . VAL A 1 12  ? -20.168 -44.435 6.231   1.00 17.04 ? 12  VAL A CG1 1 
ATOM   94   C CG2 . VAL A 1 12  ? -19.593 -42.309 7.472   1.00 16.76 ? 12  VAL A CG2 1 
ATOM   95   N N   . SER A 1 13  ? -17.730 -46.703 7.468   1.00 13.66 ? 13  SER A N   1 
ATOM   96   C CA  . SER A 1 13  ? -17.246 -47.901 6.800   1.00 18.57 ? 13  SER A CA  1 
ATOM   97   C C   . SER A 1 13  ? -18.143 -48.230 5.612   1.00 23.26 ? 13  SER A C   1 
ATOM   98   O O   . SER A 1 13  ? -19.339 -47.928 5.609   1.00 23.13 ? 13  SER A O   1 
ATOM   99   C CB  . SER A 1 13  ? -17.184 -49.098 7.753   1.00 18.58 ? 13  SER A CB  1 
ATOM   100  O OG  . SER A 1 13  ? -18.454 -49.380 8.331   1.00 21.23 ? 13  SER A OG  1 
ATOM   101  N N   . ARG A 1 14  ? -17.533 -48.841 4.595   1.00 29.03 ? 14  ARG A N   1 
ATOM   102  C CA  . ARG A 1 14  ? -18.179 -49.133 3.314   1.00 31.78 ? 14  ARG A CA  1 
ATOM   103  C C   . ARG A 1 14  ? -17.789 -50.540 2.906   1.00 38.85 ? 14  ARG A C   1 
ATOM   104  O O   . ARG A 1 14  ? -16.913 -50.729 2.052   1.00 39.31 ? 14  ARG A O   1 
ATOM   105  C CB  . ARG A 1 14  ? -17.723 -48.163 2.226   1.00 34.71 ? 14  ARG A CB  1 
ATOM   106  C CG  . ARG A 1 14  ? -17.553 -46.746 2.646   1.00 33.39 ? 14  ARG A CG  1 
ATOM   107  C CD  . ARG A 1 14  ? -17.140 -45.919 1.454   1.00 35.19 ? 14  ARG A CD  1 
ATOM   108  N NE  . ARG A 1 14  ? -15.696 -45.729 1.418   1.00 28.52 ? 14  ARG A NE  1 
ATOM   109  C CZ  . ARG A 1 14  ? -15.106 -44.739 0.769   1.00 27.66 ? 14  ARG A CZ  1 
ATOM   110  N NH1 . ARG A 1 14  ? -15.808 -43.875 0.053   1.00 24.38 ? 14  ARG A NH1 1 
ATOM   111  N NH2 . ARG A 1 14  ? -13.788 -44.593 0.865   1.00 29.94 ? 14  ARG A NH2 1 
ATOM   112  N N   . PRO A 1 15  ? -18.400 -51.557 3.510   1.00 36.98 ? 15  PRO A N   1 
ATOM   113  C CA  . PRO A 1 15  ? -17.984 -52.939 3.231   1.00 39.20 ? 15  PRO A CA  1 
ATOM   114  C C   . PRO A 1 15  ? -18.140 -53.280 1.756   1.00 38.56 ? 15  PRO A C   1 
ATOM   115  O O   . PRO A 1 15  ? -19.205 -53.088 1.162   1.00 42.47 ? 15  PRO A O   1 
ATOM   116  C CB  . PRO A 1 15  ? -18.925 -53.771 4.107   1.00 36.90 ? 15  PRO A CB  1 
ATOM   117  C CG  . PRO A 1 15  ? -19.267 -52.851 5.229   1.00 36.59 ? 15  PRO A CG  1 
ATOM   118  C CD  . PRO A 1 15  ? -19.407 -51.500 4.582   1.00 35.68 ? 15  PRO A CD  1 
ATOM   119  N N   . GLY A 1 16  ? -17.059 -53.783 1.167   1.00 43.22 ? 16  GLY A N   1 
ATOM   120  C CA  . GLY A 1 16  ? -17.031 -54.092 -0.245  1.00 42.35 ? 16  GLY A CA  1 
ATOM   121  C C   . GLY A 1 16  ? -16.623 -52.944 -1.143  1.00 45.70 ? 16  GLY A C   1 
ATOM   122  O O   . GLY A 1 16  ? -16.347 -53.175 -2.327  1.00 45.85 ? 16  GLY A O   1 
ATOM   123  N N   . ARG A 1 17  ? -16.568 -51.718 -0.625  1.00 40.90 ? 17  ARG A N   1 
ATOM   124  C CA  . ARG A 1 17  ? -16.290 -50.537 -1.434  1.00 37.37 ? 17  ARG A CA  1 
ATOM   125  C C   . ARG A 1 17  ? -15.108 -49.754 -0.877  1.00 38.02 ? 17  ARG A C   1 
ATOM   126  O O   . ARG A 1 17  ? -15.088 -48.522 -0.904  1.00 40.65 ? 17  ARG A O   1 
ATOM   127  C CB  . ARG A 1 17  ? -17.530 -49.651 -1.548  1.00 39.22 ? 17  ARG A CB  1 
ATOM   128  C CG  . ARG A 1 17  ? -18.850 -50.406 -1.415  1.00 40.20 ? 17  ARG A CG  1 
ATOM   129  C CD  . ARG A 1 17  ? -20.054 -49.559 -1.847  1.00 44.15 ? 17  ARG A CD  1 
ATOM   130  N NE  . ARG A 1 17  ? -21.326 -50.186 -1.491  1.00 45.72 ? 17  ARG A NE  1 
ATOM   131  C CZ  . ARG A 1 17  ? -22.527 -49.677 -1.756  1.00 48.76 ? 17  ARG A CZ  1 
ATOM   132  N NH1 . ARG A 1 17  ? -22.667 -48.526 -2.398  1.00 45.65 ? 17  ARG A NH1 1 
ATOM   133  N NH2 . ARG A 1 17  ? -23.616 -50.336 -1.362  1.00 41.77 ? 17  ARG A NH2 1 
ATOM   134  N N   . GLY A 1 18  ? -14.101 -50.454 -0.375  1.00 37.44 ? 18  GLY A N   1 
ATOM   135  C CA  . GLY A 1 18  ? -12.862 -49.820 0.042   1.00 39.24 ? 18  GLY A CA  1 
ATOM   136  C C   . GLY A 1 18  ? -12.794 -49.553 1.533   1.00 38.32 ? 18  GLY A C   1 
ATOM   137  O O   . GLY A 1 18  ? -13.624 -50.002 2.330   1.00 41.71 ? 18  GLY A O   1 
ATOM   138  N N   . GLU A 1 19  ? -11.761 -48.799 1.909   1.00 35.00 ? 19  GLU A N   1 
ATOM   139  C CA  . GLU A 1 19  ? -11.555 -48.418 3.294   1.00 33.96 ? 19  GLU A CA  1 
ATOM   140  C C   . GLU A 1 19  ? -12.585 -47.349 3.676   1.00 31.80 ? 19  GLU A C   1 
ATOM   141  O O   . GLU A 1 19  ? -13.183 -46.721 2.800   1.00 28.22 ? 19  GLU A O   1 
ATOM   142  C CB  . GLU A 1 19  ? -10.131 -47.897 3.477   1.00 39.14 ? 19  GLU A CB  1 
ATOM   143  C CG  . GLU A 1 19  ? -9.043  -48.981 3.688   1.00 43.82 ? 19  GLU A CG  1 
ATOM   144  C CD  . GLU A 1 19  ? -9.336  -49.971 4.814   1.00 49.03 ? 19  GLU A CD  1 
ATOM   145  O OE1 . GLU A 1 19  ? -9.854  -49.553 5.868   1.00 53.34 ? 19  GLU A OE1 1 
ATOM   146  O OE2 . GLU A 1 19  ? -9.016  -51.171 4.661   1.00 53.07 ? 19  GLU A OE2 1 
ATOM   147  N N   . PRO A 1 20  ? -12.842 -47.146 4.972   1.00 30.69 ? 20  PRO A N   1 
ATOM   148  C CA  . PRO A 1 20  ? -13.858 -46.160 5.357   1.00 24.81 ? 20  PRO A CA  1 
ATOM   149  C C   . PRO A 1 20  ? -13.508 -44.758 4.890   1.00 24.11 ? 20  PRO A C   1 
ATOM   150  O O   . PRO A 1 20  ? -12.339 -44.371 4.817   1.00 20.55 ? 20  PRO A O   1 
ATOM   151  C CB  . PRO A 1 20  ? -13.897 -46.243 6.894   1.00 19.20 ? 20  PRO A CB  1 
ATOM   152  C CG  . PRO A 1 20  ? -12.927 -47.277 7.282   1.00 27.45 ? 20  PRO A CG  1 
ATOM   153  C CD  . PRO A 1 20  ? -12.575 -48.083 6.071   1.00 32.27 ? 20  PRO A CD  1 
ATOM   154  N N   . ARG A 1 21  ? -14.551 -44.000 4.557   1.00 18.25 ? 21  ARG A N   1 
ATOM   155  C CA  . ARG A 1 21  ? -14.378 -42.599 4.221   1.00 18.50 ? 21  ARG A CA  1 
ATOM   156  C C   . ARG A 1 21  ? -14.315 -41.774 5.497   1.00 19.75 ? 21  ARG A C   1 
ATOM   157  O O   . ARG A 1 21  ? -15.164 -41.926 6.383   1.00 18.20 ? 21  ARG A O   1 
ATOM   158  C CB  . ARG A 1 21  ? -15.515 -42.102 3.340   1.00 20.90 ? 21  ARG A CB  1 
ATOM   159  C CG  . ARG A 1 21  ? -15.300 -40.668 2.938   1.00 20.83 ? 21  ARG A CG  1 
ATOM   160  C CD  . ARG A 1 21  ? -16.307 -40.241 1.948   1.00 25.85 ? 21  ARG A CD  1 
ATOM   161  N NE  . ARG A 1 21  ? -16.040 -38.902 1.440   1.00 25.16 ? 21  ARG A NE  1 
ATOM   162  C CZ  . ARG A 1 21  ? -16.835 -38.288 0.578   1.00 29.50 ? 21  ARG A CZ  1 
ATOM   163  N NH1 . ARG A 1 21  ? -17.916 -38.883 0.100   1.00 28.37 ? 21  ARG A NH1 1 
ATOM   164  N NH2 . ARG A 1 21  ? -16.551 -37.043 0.203   1.00 27.75 ? 21  ARG A NH2 1 
ATOM   165  N N   . PHE A 1 22  ? -13.328 -40.882 5.566   1.00 15.21 ? 22  PHE A N   1 
ATOM   166  C CA  . PHE A 1 22  ? -13.064 -40.044 6.731   1.00 15.34 ? 22  PHE A CA  1 
ATOM   167  C C   . PHE A 1 22  ? -13.139 -38.586 6.311   1.00 13.56 ? 22  PHE A C   1 
ATOM   168  O O   . PHE A 1 22  ? -12.491 -38.177 5.344   1.00 14.10 ? 22  PHE A O   1 
ATOM   169  C CB  . PHE A 1 22  ? -11.676 -40.351 7.306   1.00 13.21 ? 22  PHE A CB  1 
ATOM   170  C CG  . PHE A 1 22  ? -11.282 -39.495 8.490   1.00 13.08 ? 22  PHE A CG  1 
ATOM   171  C CD1 . PHE A 1 22  ? -11.618 -39.866 9.779   1.00 15.24 ? 22  PHE A CD1 1 
ATOM   172  C CD2 . PHE A 1 22  ? -10.579 -38.312 8.304   1.00 17.73 ? 22  PHE A CD2 1 
ATOM   173  C CE1 . PHE A 1 22  ? -11.221 -39.086 10.875  1.00 15.15 ? 22  PHE A CE1 1 
ATOM   174  C CE2 . PHE A 1 22  ? -10.190 -37.520 9.395   1.00 14.23 ? 22  PHE A CE2 1 
ATOM   175  C CZ  . PHE A 1 22  ? -10.536 -37.908 10.680  1.00 13.94 ? 22  PHE A CZ  1 
ATOM   176  N N   . ILE A 1 23  ? -13.896 -37.800 7.055   1.00 10.76 ? 23  ILE A N   1 
ATOM   177  C CA  . ILE A 1 23  ? -14.072 -36.381 6.790   1.00 11.91 ? 23  ILE A CA  1 
ATOM   178  C C   . ILE A 1 23  ? -13.917 -35.641 8.103   1.00 12.92 ? 23  ILE A C   1 
ATOM   179  O O   . ILE A 1 23  ? -14.507 -36.038 9.113   1.00 15.30 ? 23  ILE A O   1 
ATOM   180  C CB  . ILE A 1 23  ? -15.453 -36.073 6.166   1.00 15.79 ? 23  ILE A CB  1 
ATOM   181  C CG1 . ILE A 1 23  ? -15.652 -36.856 4.861   1.00 18.36 ? 23  ILE A CG1 1 
ATOM   182  C CG2 . ILE A 1 23  ? -15.663 -34.579 6.017   1.00 17.56 ? 23  ILE A CG2 1 
ATOM   183  C CD1 . ILE A 1 23  ? -17.012 -36.602 4.191   1.00 20.29 ? 23  ILE A CD1 1 
ATOM   184  N N   . ALA A 1 24  ? -13.153 -34.552 8.089   1.00 12.61 ? 24  ALA A N   1 
ATOM   185  C CA  . ALA A 1 24  ? -12.959 -33.749 9.286   1.00 11.74 ? 24  ALA A CA  1 
ATOM   186  C C   . ALA A 1 24  ? -13.058 -32.282 8.915   1.00 11.04 ? 24  ALA A C   1 
ATOM   187  O O   . ALA A 1 24  ? -12.565 -31.870 7.859   1.00 11.90 ? 24  ALA A O   1 
ATOM   188  C CB  . ALA A 1 24  ? -11.600 -34.021 9.934   1.00 13.93 ? 24  ALA A CB  1 
ATOM   189  N N   . VAL A 1 25  ? -13.668 -31.496 9.799   1.00 9.52  ? 25  VAL A N   1 
ATOM   190  C CA  . VAL A 1 25  ? -13.837 -30.065 9.589   1.00 9.73  ? 25  VAL A CA  1 
ATOM   191  C C   . VAL A 1 25  ? -13.492 -29.339 10.873  1.00 10.51 ? 25  VAL A C   1 
ATOM   192  O O   . VAL A 1 25  ? -13.685 -29.862 11.972  1.00 10.89 ? 25  VAL A O   1 
ATOM   193  C CB  . VAL A 1 25  ? -15.277 -29.688 9.133   1.00 10.60 ? 25  VAL A CB  1 
ATOM   194  C CG1 . VAL A 1 25  ? -15.576 -30.311 7.783   1.00 14.63 ? 25  VAL A CG1 1 
ATOM   195  C CG2 . VAL A 1 25  ? -16.355 -30.104 10.184  1.00 12.54 ? 25  VAL A CG2 1 
ATOM   196  N N   . GLY A 1 26  ? -12.962 -28.122 10.726  1.00 11.60 ? 26  GLY A N   1 
ATOM   197  C CA  . GLY A 1 26  ? -12.648 -27.289 11.868  1.00 9.71  ? 26  GLY A CA  1 
ATOM   198  C C   . GLY A 1 26  ? -13.423 -25.989 11.889  1.00 9.62  ? 26  GLY A C   1 
ATOM   199  O O   . GLY A 1 26  ? -13.566 -25.330 10.854  1.00 13.00 ? 26  GLY A O   1 
ATOM   200  N N   . TYR A 1 27  ? -13.974 -25.641 13.046  1.00 9.78  ? 27  TYR A N   1 
ATOM   201  C CA  . TYR A 1 27  ? -14.737 -24.416 13.233  1.00 13.74 ? 27  TYR A CA  1 
ATOM   202  C C   . TYR A 1 27  ? -14.113 -23.560 14.322  1.00 11.96 ? 27  TYR A C   1 
ATOM   203  O O   . TYR A 1 27  ? -13.676 -24.077 15.351  1.00 12.39 ? 27  TYR A O   1 
ATOM   204  C CB  . TYR A 1 27  ? -16.192 -24.683 13.654  1.00 10.32 ? 27  TYR A CB  1 
ATOM   205  C CG  . TYR A 1 27  ? -17.117 -25.149 12.543  1.00 14.56 ? 27  TYR A CG  1 
ATOM   206  C CD1 . TYR A 1 27  ? -17.059 -26.444 12.042  1.00 14.19 ? 27  TYR A CD1 1 
ATOM   207  C CD2 . TYR A 1 27  ? -17.983 -24.254 11.935  1.00 15.83 ? 27  TYR A CD2 1 
ATOM   208  C CE1 . TYR A 1 27  ? -17.915 -26.856 11.008  1.00 16.97 ? 27  TYR A CE1 1 
ATOM   209  C CE2 . TYR A 1 27  ? -18.825 -24.650 10.888  1.00 17.86 ? 27  TYR A CE2 1 
ATOM   210  C CZ  . TYR A 1 27  ? -18.780 -25.948 10.434  1.00 16.55 ? 27  TYR A CZ  1 
ATOM   211  O OH  . TYR A 1 27  ? -19.620 -26.332 9.406   1.00 23.09 ? 27  TYR A OH  1 
ATOM   212  N N   . VAL A 1 28  ? -14.122 -22.249 14.120  1.00 12.12 ? 28  VAL A N   1 
ATOM   213  C CA  . VAL A 1 28  ? -14.012 -21.293 15.212  1.00 12.77 ? 28  VAL A CA  1 
ATOM   214  C C   . VAL A 1 28  ? -15.377 -20.635 15.358  1.00 12.84 ? 28  VAL A C   1 
ATOM   215  O O   . VAL A 1 28  ? -15.881 -20.014 14.406  1.00 13.72 ? 28  VAL A O   1 
ATOM   216  C CB  . VAL A 1 28  ? -12.906 -20.256 14.974  1.00 13.61 ? 28  VAL A CB  1 
ATOM   217  C CG1 . VAL A 1 28  ? -13.000 -19.160 16.032  1.00 13.14 ? 28  VAL A CG1 1 
ATOM   218  C CG2 . VAL A 1 28  ? -11.523 -20.927 15.066  1.00 15.74 ? 28  VAL A CG2 1 
ATOM   219  N N   . ASP A 1 29  ? -16.011 -20.826 16.522  1.00 13.71 ? 29  ASP A N   1 
ATOM   220  C CA  . ASP A 1 29  ? -17.378 -20.334 16.752  1.00 15.41 ? 29  ASP A CA  1 
ATOM   221  C C   . ASP A 1 29  ? -18.272 -20.930 15.666  1.00 15.41 ? 29  ASP A C   1 
ATOM   222  O O   . ASP A 1 29  ? -18.294 -22.165 15.502  1.00 13.13 ? 29  ASP A O   1 
ATOM   223  C CB  . ASP A 1 29  ? -17.301 -18.811 16.782  1.00 17.01 ? 29  ASP A CB  1 
ATOM   224  C CG  . ASP A 1 29  ? -16.679 -18.278 18.052  1.00 21.75 ? 29  ASP A CG  1 
ATOM   225  O OD1 . ASP A 1 29  ? -16.506 -19.045 19.025  1.00 21.19 ? 29  ASP A OD1 1 
ATOM   226  O OD2 . ASP A 1 29  ? -16.227 -17.113 18.014  1.00 25.95 ? 29  ASP A OD2 1 
ATOM   227  N N   . ASP A 1 30  ? -18.968 -20.122 14.866  1.00 13.07 ? 30  ASP A N   1 
ATOM   228  C CA  . ASP A 1 30  ? -19.826 -20.616 13.796  1.00 14.07 ? 30  ASP A CA  1 
ATOM   229  C C   . ASP A 1 30  ? -19.176 -20.515 12.417  1.00 16.99 ? 30  ASP A C   1 
ATOM   230  O O   . ASP A 1 30  ? -19.885 -20.523 11.403  1.00 15.65 ? 30  ASP A O   1 
ATOM   231  C CB  . ASP A 1 30  ? -21.155 -19.852 13.813  1.00 15.95 ? 30  ASP A CB  1 
ATOM   232  C CG  . ASP A 1 30  ? -21.939 -20.080 15.103  1.00 18.56 ? 30  ASP A CG  1 
ATOM   233  O OD1 . ASP A 1 30  ? -21.993 -21.240 15.561  1.00 20.03 ? 30  ASP A OD1 1 
ATOM   234  O OD2 . ASP A 1 30  ? -22.461 -19.103 15.687  1.00 17.59 ? 30  ASP A OD2 1 
ATOM   235  N N   . THR A 1 31  ? -17.851 -20.421 12.347  1.00 13.39 ? 31  THR A N   1 
ATOM   236  C CA  . THR A 1 31  ? -17.150 -20.183 11.088  1.00 13.23 ? 31  THR A CA  1 
ATOM   237  C C   . THR A 1 31  ? -16.246 -21.374 10.803  1.00 15.10 ? 31  THR A C   1 
ATOM   238  O O   . THR A 1 31  ? -15.358 -21.679 11.602  1.00 11.27 ? 31  THR A O   1 
ATOM   239  C CB  . THR A 1 31  ? -16.334 -18.882 11.145  1.00 16.35 ? 31  THR A CB  1 
ATOM   240  O OG1 . THR A 1 31  ? -17.188 -17.766 11.430  1.00 15.91 ? 31  THR A OG1 1 
ATOM   241  C CG2 . THR A 1 31  ? -15.580 -18.638 9.850   1.00 20.73 ? 31  THR A CG2 1 
ATOM   242  N N   . GLN A 1 32  ? -16.495 -22.071 9.696   1.00 13.93 ? 32  GLN A N   1 
ATOM   243  C CA  . GLN A 1 32  ? -15.612 -23.169 9.321   1.00 16.06 ? 32  GLN A CA  1 
ATOM   244  C C   . GLN A 1 32  ? -14.297 -22.608 8.789   1.00 14.01 ? 32  GLN A C   1 
ATOM   245  O O   . GLN A 1 32  ? -14.286 -21.567 8.132   1.00 14.64 ? 32  GLN A O   1 
ATOM   246  C CB  . GLN A 1 32  ? -16.279 -24.055 8.269   1.00 14.84 ? 32  GLN A CB  1 
ATOM   247  C CG  . GLN A 1 32  ? -15.534 -25.362 8.050   1.00 15.35 ? 32  GLN A CG  1 
ATOM   248  C CD  . GLN A 1 32  ? -15.917 -26.044 6.744   1.00 19.40 ? 32  GLN A CD  1 
ATOM   249  O OE1 . GLN A 1 32  ? -16.945 -25.742 6.150   1.00 20.81 ? 32  GLN A OE1 1 
ATOM   250  N NE2 . GLN A 1 32  ? -15.061 -26.942 6.275   1.00 18.29 ? 32  GLN A NE2 1 
ATOM   251  N N   . PHE A 1 33  ? -13.168 -23.273 9.093   1.00 14.54 ? 33  PHE A N   1 
ATOM   252  C CA  . PHE A 1 33  ? -11.894 -22.794 8.547   1.00 14.61 ? 33  PHE A CA  1 
ATOM   253  C C   . PHE A 1 33  ? -10.989 -23.852 7.924   1.00 12.46 ? 33  PHE A C   1 
ATOM   254  O O   . PHE A 1 33  ? -10.102 -23.474 7.147   1.00 14.80 ? 33  PHE A O   1 
ATOM   255  C CB  . PHE A 1 33  ? -11.099 -22.006 9.607   1.00 12.58 ? 33  PHE A CB  1 
ATOM   256  C CG  . PHE A 1 33  ? -10.565 -22.828 10.757  1.00 12.48 ? 33  PHE A CG  1 
ATOM   257  C CD1 . PHE A 1 33  ? -11.397 -23.249 11.798  1.00 12.24 ? 33  PHE A CD1 1 
ATOM   258  C CD2 . PHE A 1 33  ? -9.208  -23.131 10.820  1.00 16.39 ? 33  PHE A CD2 1 
ATOM   259  C CE1 . PHE A 1 33  ? -10.876 -23.990 12.863  1.00 14.13 ? 33  PHE A CE1 1 
ATOM   260  C CE2 . PHE A 1 33  ? -8.677  -23.854 11.879  1.00 15.95 ? 33  PHE A CE2 1 
ATOM   261  C CZ  . PHE A 1 33  ? -9.513  -24.287 12.908  1.00 14.32 ? 33  PHE A CZ  1 
ATOM   262  N N   . VAL A 1 34  ? -11.180 -25.144 8.193   1.00 12.41 ? 34  VAL A N   1 
ATOM   263  C CA  . VAL A 1 34  ? -10.404 -26.187 7.524   1.00 11.25 ? 34  VAL A CA  1 
ATOM   264  C C   . VAL A 1 34  ? -11.289 -27.395 7.269   1.00 14.71 ? 34  VAL A C   1 
ATOM   265  O O   . VAL A 1 34  ? -12.330 -27.591 7.910   1.00 10.56 ? 34  VAL A O   1 
ATOM   266  C CB  . VAL A 1 34  ? -9.150  -26.649 8.325   1.00 15.03 ? 34  VAL A CB  1 
ATOM   267  C CG1 . VAL A 1 34  ? -8.052  -25.618 8.269   1.00 14.98 ? 34  VAL A CG1 1 
ATOM   268  C CG2 . VAL A 1 34  ? -9.515  -26.932 9.778   1.00 12.33 ? 34  VAL A CG2 1 
ATOM   269  N N   . ARG A 1 35  ? -10.830 -28.231 6.343   1.00 10.03 ? 35  ARG A N   1 
ATOM   270  C CA  . ARG A 1 35  ? -11.485 -29.487 6.046   1.00 13.04 ? 35  ARG A CA  1 
ATOM   271  C C   . ARG A 1 35  ? -10.449 -30.495 5.585   1.00 12.54 ? 35  ARG A C   1 
ATOM   272  O O   . ARG A 1 35  ? -9.404  -30.126 5.054   1.00 14.71 ? 35  ARG A O   1 
ATOM   273  C CB  . ARG A 1 35  ? -12.550 -29.294 4.960   1.00 11.46 ? 35  ARG A CB  1 
ATOM   274  C CG  . ARG A 1 35  ? -11.944 -29.441 3.567   1.00 16.64 ? 35  ARG A CG  1 
ATOM   275  C CD  . ARG A 1 35  ? -12.992 -29.618 2.496   1.00 20.21 ? 35  ARG A CD  1 
ATOM   276  N NE  . ARG A 1 35  ? -12.477 -29.197 1.201   1.00 29.14 ? 35  ARG A NE  1 
ATOM   277  C CZ  . ARG A 1 35  ? -13.252 -28.863 0.179   1.00 28.33 ? 35  ARG A CZ  1 
ATOM   278  N NH1 . ARG A 1 35  ? -14.563 -28.833 0.300   1.00 20.38 ? 35  ARG A NH1 1 
ATOM   279  N NH2 . ARG A 1 35  ? -12.693 -28.557 -0.989  1.00 30.16 ? 35  ARG A NH2 1 
ATOM   280  N N   . PHE A 1 36  ? -10.766 -31.775 5.775   1.00 12.48 ? 36  PHE A N   1 
ATOM   281  C CA  . PHE A 1 36  ? -10.008 -32.872 5.196   1.00 11.71 ? 36  PHE A CA  1 
ATOM   282  C C   . PHE A 1 36  ? -11.000 -33.935 4.753   1.00 16.52 ? 36  PHE A C   1 
ATOM   283  O O   . PHE A 1 36  ? -11.927 -34.270 5.498   1.00 12.15 ? 36  PHE A O   1 
ATOM   284  C CB  . PHE A 1 36  ? -9.004  -33.459 6.198   1.00 9.61  ? 36  PHE A CB  1 
ATOM   285  C CG  . PHE A 1 36  ? -8.243  -34.644 5.665   1.00 11.92 ? 36  PHE A CG  1 
ATOM   286  C CD1 . PHE A 1 36  ? -7.116  -34.459 4.876   1.00 15.83 ? 36  PHE A CD1 1 
ATOM   287  C CD2 . PHE A 1 36  ? -8.643  -35.939 5.957   1.00 14.04 ? 36  PHE A CD2 1 
ATOM   288  C CE1 . PHE A 1 36  ? -6.409  -35.551 4.369   1.00 15.80 ? 36  PHE A CE1 1 
ATOM   289  C CE2 . PHE A 1 36  ? -7.939  -37.042 5.450   1.00 17.04 ? 36  PHE A CE2 1 
ATOM   290  C CZ  . PHE A 1 36  ? -6.826  -36.840 4.649   1.00 12.66 ? 36  PHE A CZ  1 
ATOM   291  N N   . ASP A 1 37  ? -10.807 -34.455 3.544   1.00 13.17 ? 37  ASP A N   1 
ATOM   292  C CA  . ASP A 1 37  ? -11.627 -35.522 2.967   1.00 13.18 ? 37  ASP A CA  1 
ATOM   293  C C   . ASP A 1 37  ? -10.717 -36.634 2.474   1.00 16.63 ? 37  ASP A C   1 
ATOM   294  O O   . ASP A 1 37  ? -9.959  -36.436 1.522   1.00 16.91 ? 37  ASP A O   1 
ATOM   295  C CB  . ASP A 1 37  ? -12.497 -34.984 1.824   1.00 17.92 ? 37  ASP A CB  1 
ATOM   296  C CG  . ASP A 1 37  ? -13.489 -36.015 1.290   1.00 23.09 ? 37  ASP A CG  1 
ATOM   297  O OD1 . ASP A 1 37  ? -13.407 -37.205 1.682   1.00 20.75 ? 37  ASP A OD1 1 
ATOM   298  O OD2 . ASP A 1 37  ? -14.356 -35.634 0.466   1.00 28.78 ? 37  ASP A OD2 1 
ATOM   299  N N   . SER A 1 38  ? -10.816 -37.811 3.092   1.00 14.76 ? 38  SER A N   1 
ATOM   300  C CA  . SER A 1 38  ? -9.934  -38.908 2.713   1.00 15.49 ? 38  SER A CA  1 
ATOM   301  C C   . SER A 1 38  ? -10.160 -39.380 1.282   1.00 21.98 ? 38  SER A C   1 
ATOM   302  O O   . SER A 1 38  ? -9.244  -39.952 0.687   1.00 19.63 ? 38  SER A O   1 
ATOM   303  C CB  . SER A 1 38  ? -10.107 -40.068 3.694   1.00 17.31 ? 38  SER A CB  1 
ATOM   304  O OG  . SER A 1 38  ? -11.355 -40.711 3.486   1.00 21.61 ? 38  SER A OG  1 
ATOM   305  N N   . ASP A 1 39  ? -11.351 -39.170 0.714   1.00 20.04 ? 39  ASP A N   1 
ATOM   306  C CA  . ASP A 1 39  ? -11.557 -39.522 -0.687  1.00 23.44 ? 39  ASP A CA  1 
ATOM   307  C C   . ASP A 1 39  ? -11.073 -38.456 -1.661  1.00 27.35 ? 39  ASP A C   1 
ATOM   308  O O   . ASP A 1 39  ? -11.036 -38.727 -2.864  1.00 29.60 ? 39  ASP A O   1 
ATOM   309  C CB  . ASP A 1 39  ? -13.037 -39.796 -0.980  1.00 22.58 ? 39  ASP A CB  1 
ATOM   310  C CG  . ASP A 1 39  ? -13.494 -41.145 -0.476  1.00 25.79 ? 39  ASP A CG  1 
ATOM   311  O OD1 . ASP A 1 39  ? -12.664 -41.899 0.084   1.00 28.24 ? 39  ASP A OD1 1 
ATOM   312  O OD2 . ASP A 1 39  ? -14.692 -41.458 -0.659  1.00 31.94 ? 39  ASP A OD2 1 
ATOM   313  N N   . ALA A 1 40  ? -10.726 -37.260 -1.195  1.00 24.30 ? 40  ALA A N   1 
ATOM   314  C CA  . ALA A 1 40  ? -10.326 -36.225 -2.131  1.00 21.22 ? 40  ALA A CA  1 
ATOM   315  C C   . ALA A 1 40  ? -8.924  -36.505 -2.659  1.00 22.42 ? 40  ALA A C   1 
ATOM   316  O O   . ALA A 1 40  ? -8.122  -37.219 -2.041  1.00 25.33 ? 40  ALA A O   1 
ATOM   317  C CB  . ALA A 1 40  ? -10.383 -34.844 -1.482  1.00 22.52 ? 40  ALA A CB  1 
ATOM   318  N N   . ALA A 1 41  ? -8.627  -35.924 -3.820  1.00 20.54 ? 41  ALA A N   1 
ATOM   319  C CA  . ALA A 1 41  ? -7.348  -36.204 -4.472  1.00 22.43 ? 41  ALA A CA  1 
ATOM   320  C C   . ALA A 1 41  ? -6.162  -35.663 -3.670  1.00 21.84 ? 41  ALA A C   1 
ATOM   321  O O   . ALA A 1 41  ? -5.131  -36.334 -3.557  1.00 26.62 ? 41  ALA A O   1 
ATOM   322  C CB  . ALA A 1 41  ? -7.349  -35.625 -5.888  1.00 24.57 ? 41  ALA A CB  1 
ATOM   323  N N   . SER A 1 42  ? -6.290  -34.462 -3.096  1.00 22.22 ? 42  SER A N   1 
ATOM   324  C CA  . SER A 1 42  ? -5.138  -33.763 -2.518  1.00 20.17 ? 42  SER A CA  1 
ATOM   325  C C   . SER A 1 42  ? -4.499  -34.518 -1.350  1.00 21.15 ? 42  SER A C   1 
ATOM   326  O O   . SER A 1 42  ? -3.271  -34.484 -1.179  1.00 18.69 ? 42  SER A O   1 
ATOM   327  C CB  . SER A 1 42  ? -5.565  -32.368 -2.062  1.00 22.93 ? 42  SER A CB  1 
ATOM   328  O OG  . SER A 1 42  ? -6.172  -32.436 -0.771  1.00 24.10 ? 42  SER A OG  1 
ATOM   329  N N   . GLN A 1 43  ? -5.308  -35.159 -0.508  1.00 21.00 ? 43  GLN A N   1 
ATOM   330  C CA  . GLN A 1 43  ? -4.840  -35.762 0.747   1.00 18.80 ? 43  GLN A CA  1 
ATOM   331  C C   . GLN A 1 43  ? -4.190  -34.718 1.662   1.00 17.35 ? 43  GLN A C   1 
ATOM   332  O O   . GLN A 1 43  ? -3.245  -35.022 2.398   1.00 17.63 ? 43  GLN A O   1 
ATOM   333  C CB  . GLN A 1 43  ? -3.881  -36.930 0.482   1.00 22.26 ? 43  GLN A CB  1 
ATOM   334  C CG  . GLN A 1 43  ? -4.548  -38.065 -0.296  1.00 24.51 ? 43  GLN A CG  1 
ATOM   335  C CD  . GLN A 1 43  ? -5.631  -38.785 0.497   1.00 24.02 ? 43  GLN A CD  1 
ATOM   336  O OE1 . GLN A 1 43  ? -5.372  -39.323 1.572   1.00 24.24 ? 43  GLN A OE1 1 
ATOM   337  N NE2 . GLN A 1 43  ? -6.864  -38.754 -0.018  1.00 22.44 ? 43  GLN A NE2 1 
ATOM   338  N N   . ARG A 1 44  ? -4.682  -33.478 1.621   1.00 15.51 ? 44  ARG A N   1 
ATOM   339  C CA  . ARG A 1 44  ? -4.166  -32.387 2.443   1.00 16.82 ? 44  ARG A CA  1 
ATOM   340  C C   . ARG A 1 44  ? -5.289  -31.774 3.267   1.00 15.09 ? 44  ARG A C   1 
ATOM   341  O O   . ARG A 1 44  ? -6.438  -31.723 2.824   1.00 14.14 ? 44  ARG A O   1 
ATOM   342  C CB  . ARG A 1 44  ? -3.543  -31.276 1.597   1.00 14.98 ? 44  ARG A CB  1 
ATOM   343  C CG  . ARG A 1 44  ? -2.392  -31.779 0.718   1.00 20.43 ? 44  ARG A CG  1 
ATOM   344  C CD  . ARG A 1 44  ? -1.063  -31.714 1.440   1.00 16.28 ? 44  ARG A CD  1 
ATOM   345  N NE  . ARG A 1 44  ? -0.680  -30.363 1.825   1.00 19.19 ? 44  ARG A NE  1 
ATOM   346  C CZ  . ARG A 1 44  ? 0.408   -30.065 2.526   1.00 19.09 ? 44  ARG A CZ  1 
ATOM   347  N NH1 . ARG A 1 44  ? 1.205   -31.006 3.006   1.00 19.62 ? 44  ARG A NH1 1 
ATOM   348  N NH2 . ARG A 1 44  ? 0.717   -28.790 2.731   1.00 23.78 ? 44  ARG A NH2 1 
ATOM   349  N N   . MET A 1 45  ? -4.935  -31.283 4.451   1.00 11.68 ? 45  MET A N   1 
ATOM   350  C CA  . MET A 1 45  ? -5.801  -30.355 5.169   1.00 16.00 ? 45  MET A CA  1 
ATOM   351  C C   . MET A 1 45  ? -5.916  -29.112 4.307   1.00 17.96 ? 45  MET A C   1 
ATOM   352  O O   . MET A 1 45  ? -4.902  -28.599 3.827   1.00 15.85 ? 45  MET A O   1 
ATOM   353  C CB  . MET A 1 45  ? -5.176  -29.974 6.506   1.00 14.92 ? 45  MET A CB  1 
ATOM   354  C CG  . MET A 1 45  ? -6.041  -29.367 7.599   1.00 17.69 ? 45  MET A CG  1 
ATOM   355  S SD  . MET A 1 45  ? -7.579  -30.168 8.053   1.00 17.05 ? 45  MET A SD  1 
ATOM   356  C CE  . MET A 1 45  ? -7.103  -30.649 9.707   1.00 21.34 ? 45  MET A CE  1 
ATOM   357  N N   . GLU A 1 46  ? -7.146  -28.630 4.089   1.00 14.24 ? 46  GLU A N   1 
ATOM   358  C CA  . GLU A 1 46  ? -7.354  -27.524 3.167   1.00 15.21 ? 46  GLU A CA  1 
ATOM   359  C C   . GLU A 1 46  ? -8.024  -26.335 3.848   1.00 15.71 ? 46  GLU A C   1 
ATOM   360  O O   . GLU A 1 46  ? -8.907  -26.517 4.697   1.00 15.69 ? 46  GLU A O   1 
ATOM   361  C CB  . GLU A 1 46  ? -8.207  -27.994 1.980   1.00 19.69 ? 46  GLU A CB  1 
ATOM   362  C CG  . GLU A 1 46  ? -7.600  -29.194 1.259   1.00 21.16 ? 46  GLU A CG  1 
ATOM   363  C CD  . GLU A 1 46  ? -8.262  -29.467 -0.084  1.00 32.49 ? 46  GLU A CD  1 
ATOM   364  O OE1 . GLU A 1 46  ? -7.607  -30.061 -0.978  1.00 36.56 ? 46  GLU A OE1 1 
ATOM   365  O OE2 . GLU A 1 46  ? -9.461  -29.125 -0.218  1.00 30.50 ? 46  GLU A OE2 1 
ATOM   366  N N   . PRO A 1 47  ? -7.624  -25.114 3.492   1.00 16.66 ? 47  PRO A N   1 
ATOM   367  C CA  . PRO A 1 47  ? -8.263  -23.915 4.053   1.00 16.86 ? 47  PRO A CA  1 
ATOM   368  C C   . PRO A 1 47  ? -9.694  -23.764 3.566   1.00 17.54 ? 47  PRO A C   1 
ATOM   369  O O   . PRO A 1 47  ? -10.008 -24.064 2.412   1.00 16.55 ? 47  PRO A O   1 
ATOM   370  C CB  . PRO A 1 47  ? -7.408  -22.764 3.511   1.00 16.99 ? 47  PRO A CB  1 
ATOM   371  C CG  . PRO A 1 47  ? -6.717  -23.318 2.327   1.00 18.49 ? 47  PRO A CG  1 
ATOM   372  C CD  . PRO A 1 47  ? -6.589  -24.797 2.493   1.00 16.14 ? 47  PRO A CD  1 
ATOM   373  N N   . ARG A 1 48  ? -10.560 -23.268 4.460   1.00 17.56 ? 48  ARG A N   1 
ATOM   374  C CA  . ARG A 1 48  ? -11.942 -22.953 4.118   1.00 16.83 ? 48  ARG A CA  1 
ATOM   375  C C   . ARG A 1 48  ? -12.364 -21.571 4.613   1.00 20.16 ? 48  ARG A C   1 
ATOM   376  O O   . ARG A 1 48  ? -13.566 -21.252 4.594   1.00 17.95 ? 48  ARG A O   1 
ATOM   377  C CB  . ARG A 1 48  ? -12.885 -24.026 4.681   1.00 16.92 ? 48  ARG A CB  1 
ATOM   378  C CG  . ARG A 1 48  ? -12.645 -25.430 4.096   1.00 17.22 ? 48  ARG A CG  1 
ATOM   379  C CD  . ARG A 1 48  ? -12.986 -25.508 2.606   1.00 18.90 ? 48  ARG A CD  1 
ATOM   380  N NE  . ARG A 1 48  ? -14.396 -25.829 2.423   1.00 19.28 ? 48  ARG A NE  1 
ATOM   381  C CZ  . ARG A 1 48  ? -15.104 -25.507 1.347   1.00 23.53 ? 48  ARG A CZ  1 
ATOM   382  N NH1 . ARG A 1 48  ? -14.543 -24.917 0.301   1.00 21.92 ? 48  ARG A NH1 1 
ATOM   383  N NH2 . ARG A 1 48  ? -16.403 -25.801 1.311   1.00 20.41 ? 48  ARG A NH2 1 
ATOM   384  N N   . ALA A 1 49  ? -11.422 -20.753 5.067   1.00 20.10 ? 49  ALA A N   1 
ATOM   385  C CA  . ALA A 1 49  ? -11.665 -19.383 5.487   1.00 22.75 ? 49  ALA A CA  1 
ATOM   386  C C   . ALA A 1 49  ? -10.517 -18.531 4.982   1.00 24.97 ? 49  ALA A C   1 
ATOM   387  O O   . ALA A 1 49  ? -9.379  -19.002 4.925   1.00 25.12 ? 49  ALA A O   1 
ATOM   388  C CB  . ALA A 1 49  ? -11.768 -19.248 7.015   1.00 19.35 ? 49  ALA A CB  1 
ATOM   389  N N   . PRO A 1 50  ? -10.782 -17.278 4.605   1.00 27.91 ? 50  PRO A N   1 
ATOM   390  C CA  . PRO A 1 50  ? -9.691  -16.424 4.106   1.00 28.99 ? 50  PRO A CA  1 
ATOM   391  C C   . PRO A 1 50  ? -8.556  -16.218 5.102   1.00 27.31 ? 50  PRO A C   1 
ATOM   392  O O   . PRO A 1 50  ? -7.391  -16.153 4.697   1.00 28.74 ? 50  PRO A O   1 
ATOM   393  C CB  . PRO A 1 50  ? -10.415 -15.109 3.789   1.00 28.84 ? 50  PRO A CB  1 
ATOM   394  C CG  . PRO A 1 50  ? -11.825 -15.516 3.525   1.00 30.22 ? 50  PRO A CG  1 
ATOM   395  C CD  . PRO A 1 50  ? -12.087 -16.601 4.521   1.00 28.24 ? 50  PRO A CD  1 
ATOM   396  N N   . TRP A 1 51  ? -8.857  -16.115 6.396   1.00 24.96 ? 51  TRP A N   1 
ATOM   397  C CA  . TRP A 1 51  ? -7.849  -15.751 7.380   1.00 27.52 ? 51  TRP A CA  1 
ATOM   398  C C   . TRP A 1 51  ? -6.931  -16.902 7.771   1.00 27.66 ? 51  TRP A C   1 
ATOM   399  O O   . TRP A 1 51  ? -5.899  -16.654 8.402   1.00 28.48 ? 51  TRP A O   1 
ATOM   400  C CB  . TRP A 1 51  ? -8.518  -15.180 8.635   1.00 26.43 ? 51  TRP A CB  1 
ATOM   401  C CG  . TRP A 1 51  ? -9.699  -15.953 9.103   1.00 24.06 ? 51  TRP A CG  1 
ATOM   402  C CD1 . TRP A 1 51  ? -11.006 -15.718 8.784   1.00 27.91 ? 51  TRP A CD1 1 
ATOM   403  C CD2 . TRP A 1 51  ? -9.695  -17.092 9.973   1.00 22.93 ? 51  TRP A CD2 1 
ATOM   404  N NE1 . TRP A 1 51  ? -11.815 -16.639 9.407   1.00 28.22 ? 51  TRP A NE1 1 
ATOM   405  C CE2 . TRP A 1 51  ? -11.033 -17.497 10.136  1.00 23.59 ? 51  TRP A CE2 1 
ATOM   406  C CE3 . TRP A 1 51  ? -8.687  -17.810 10.629  1.00 22.95 ? 51  TRP A CE3 1 
ATOM   407  C CZ2 . TRP A 1 51  ? -11.394 -18.580 10.933  1.00 21.38 ? 51  TRP A CZ2 1 
ATOM   408  C CZ3 . TRP A 1 51  ? -9.043  -18.891 11.412  1.00 18.13 ? 51  TRP A CZ3 1 
ATOM   409  C CH2 . TRP A 1 51  ? -10.385 -19.260 11.569  1.00 20.70 ? 51  TRP A CH2 1 
ATOM   410  N N   . ILE A 1 52  ? -7.269  -18.146 7.433   1.00 22.40 ? 52  ILE A N   1 
ATOM   411  C CA  . ILE A 1 52  ? -6.349  -19.242 7.717   1.00 22.14 ? 52  ILE A CA  1 
ATOM   412  C C   . ILE A 1 52  ? -5.301  -19.384 6.620   1.00 24.99 ? 52  ILE A C   1 
ATOM   413  O O   . ILE A 1 52  ? -4.281  -20.056 6.830   1.00 23.70 ? 52  ILE A O   1 
ATOM   414  C CB  . ILE A 1 52  ? -7.106  -20.571 7.908   1.00 19.90 ? 52  ILE A CB  1 
ATOM   415  C CG1 . ILE A 1 52  ? -6.295  -21.561 8.758   1.00 18.18 ? 52  ILE A CG1 1 
ATOM   416  C CG2 . ILE A 1 52  ? -7.535  -21.155 6.575   1.00 18.24 ? 52  ILE A CG2 1 
ATOM   417  C CD1 . ILE A 1 52  ? -5.878  -20.994 10.083  1.00 19.27 ? 52  ILE A CD1 1 
ATOM   418  N N   . GLU A 1 53  ? -5.521  -18.773 5.456   1.00 23.52 ? 53  GLU A N   1 
ATOM   419  C CA  . GLU A 1 53  ? -4.546  -18.844 4.370   1.00 28.26 ? 53  GLU A CA  1 
ATOM   420  C C   . GLU A 1 53  ? -3.245  -18.120 4.689   1.00 29.16 ? 53  GLU A C   1 
ATOM   421  O O   . GLU A 1 53  ? -2.263  -18.317 3.968   1.00 36.14 ? 53  GLU A O   1 
ATOM   422  C CB  . GLU A 1 53  ? -5.149  -18.285 3.080   1.00 31.92 ? 53  GLU A CB  1 
ATOM   423  C CG  . GLU A 1 53  ? -6.391  -19.036 2.610   1.00 28.89 ? 53  GLU A CG  1 
ATOM   424  C CD  . GLU A 1 53  ? -7.135  -18.315 1.507   1.00 40.40 ? 53  GLU A CD  1 
ATOM   425  O OE1 . GLU A 1 53  ? -6.668  -17.238 1.077   1.00 45.43 ? 53  GLU A OE1 1 
ATOM   426  O OE2 . GLU A 1 53  ? -8.202  -18.815 1.083   1.00 40.47 ? 53  GLU A OE2 1 
ATOM   427  N N   . GLN A 1 54  ? -3.207  -17.298 5.743   1.00 33.79 ? 54  GLN A N   1 
ATOM   428  C CA  . GLN A 1 54  ? -1.952  -16.702 6.195   1.00 32.27 ? 54  GLN A CA  1 
ATOM   429  C C   . GLN A 1 54  ? -0.996  -17.723 6.792   1.00 34.75 ? 54  GLN A C   1 
ATOM   430  O O   . GLN A 1 54  ? 0.209   -17.462 6.848   1.00 36.06 ? 54  GLN A O   1 
ATOM   431  C CB  . GLN A 1 54  ? -2.204  -15.636 7.259   1.00 31.84 ? 54  GLN A CB  1 
ATOM   432  C CG  . GLN A 1 54  ? -3.562  -15.017 7.231   1.00 39.60 ? 54  GLN A CG  1 
ATOM   433  C CD  . GLN A 1 54  ? -3.739  -13.971 8.317   1.00 39.01 ? 54  GLN A CD  1 
ATOM   434  O OE1 . GLN A 1 54  ? -2.866  -13.788 9.170   1.00 41.32 ? 54  GLN A OE1 1 
ATOM   435  N NE2 . GLN A 1 54  ? -4.891  -13.302 8.311   1.00 39.01 ? 54  GLN A NE2 1 
ATOM   436  N N   . GLU A 1 55  ? -1.498  -18.851 7.288   1.00 29.40 ? 55  GLU A N   1 
ATOM   437  C CA  . GLU A 1 55  ? -0.623  -19.817 7.941   1.00 27.64 ? 55  GLU A CA  1 
ATOM   438  C C   . GLU A 1 55  ? 0.389   -20.355 6.935   1.00 28.07 ? 55  GLU A C   1 
ATOM   439  O O   . GLU A 1 55  ? 0.067   -20.554 5.761   1.00 30.68 ? 55  GLU A O   1 
ATOM   440  C CB  . GLU A 1 55  ? -1.450  -20.960 8.519   1.00 24.72 ? 55  GLU A CB  1 
ATOM   441  C CG  . GLU A 1 55  ? -2.395  -20.525 9.617   1.00 22.93 ? 55  GLU A CG  1 
ATOM   442  C CD  . GLU A 1 55  ? -1.696  -20.218 10.912  1.00 29.52 ? 55  GLU A CD  1 
ATOM   443  O OE1 . GLU A 1 55  ? -0.473  -20.476 11.016  1.00 33.94 ? 55  GLU A OE1 1 
ATOM   444  O OE2 . GLU A 1 55  ? -2.370  -19.696 11.823  1.00 32.70 ? 55  GLU A OE2 1 
ATOM   445  N N   . GLY A 1 56  ? 1.612   -20.611 7.402   1.00 28.88 ? 56  GLY A N   1 
ATOM   446  C CA  . GLY A 1 56  ? 2.695   -20.974 6.513   1.00 27.44 ? 56  GLY A CA  1 
ATOM   447  C C   . GLY A 1 56  ? 2.711   -22.451 6.173   1.00 26.70 ? 56  GLY A C   1 
ATOM   448  O O   . GLY A 1 56  ? 1.893   -23.252 6.648   1.00 22.27 ? 56  GLY A O   1 
ATOM   449  N N   . PRO A 1 57  ? 3.682   -22.833 5.334   1.00 26.45 ? 57  PRO A N   1 
ATOM   450  C CA  . PRO A 1 57  ? 3.721   -24.219 4.837   1.00 25.75 ? 57  PRO A CA  1 
ATOM   451  C C   . PRO A 1 57  ? 3.895   -25.254 5.929   1.00 20.80 ? 57  PRO A C   1 
ATOM   452  O O   . PRO A 1 57  ? 3.370   -26.367 5.808   1.00 22.25 ? 57  PRO A O   1 
ATOM   453  C CB  . PRO A 1 57  ? 4.929   -24.212 3.884   1.00 31.72 ? 57  PRO A CB  1 
ATOM   454  C CG  . PRO A 1 57  ? 5.032   -22.796 3.436   1.00 34.22 ? 57  PRO A CG  1 
ATOM   455  C CD  . PRO A 1 57  ? 4.679   -21.982 4.659   1.00 31.62 ? 57  PRO A CD  1 
ATOM   456  N N   . GLU A 1 58  ? 4.626   -24.939 6.991   1.00 23.02 ? 58  GLU A N   1 
ATOM   457  C CA  . GLU A 1 58  ? 4.798   -25.918 8.054   1.00 22.96 ? 58  GLU A CA  1 
ATOM   458  C C   . GLU A 1 58  ? 3.474   -26.195 8.774   1.00 21.72 ? 58  GLU A C   1 
ATOM   459  O O   . GLU A 1 58  ? 3.242   -27.321 9.234   1.00 16.81 ? 58  GLU A O   1 
ATOM   460  C CB  . GLU A 1 58  ? 5.876   -25.441 9.028   1.00 27.65 ? 58  GLU A CB  1 
ATOM   461  C CG  . GLU A 1 58  ? 5.567   -24.149 9.819   1.00 34.29 ? 58  GLU A CG  1 
ATOM   462  C CD  . GLU A 1 58  ? 5.278   -22.915 8.949   1.00 36.19 ? 58  GLU A CD  1 
ATOM   463  O OE1 . GLU A 1 58  ? 4.142   -22.371 9.063   1.00 38.04 ? 58  GLU A OE1 1 
ATOM   464  O OE2 . GLU A 1 58  ? 6.162   -22.510 8.145   1.00 33.58 ? 58  GLU A OE2 1 
ATOM   465  N N   . TYR A 1 59  ? 2.603   -25.189 8.874   1.00 19.17 ? 59  TYR A N   1 
ATOM   466  C CA  . TYR A 1 59  ? 1.258   -25.409 9.408   1.00 19.37 ? 59  TYR A CA  1 
ATOM   467  C C   . TYR A 1 59  ? 0.532   -26.482 8.603   1.00 20.31 ? 59  TYR A C   1 
ATOM   468  O O   . TYR A 1 59  ? 0.082   -27.500 9.148   1.00 17.26 ? 59  TYR A O   1 
ATOM   469  C CB  . TYR A 1 59  ? 0.480   -24.088 9.392   1.00 18.35 ? 59  TYR A CB  1 
ATOM   470  C CG  . TYR A 1 59  ? -0.938  -24.181 9.924   1.00 17.04 ? 59  TYR A CG  1 
ATOM   471  C CD1 . TYR A 1 59  ? -1.196  -24.082 11.284  1.00 23.27 ? 59  TYR A CD1 1 
ATOM   472  C CD2 . TYR A 1 59  ? -2.016  -24.386 9.057   1.00 20.01 ? 59  TYR A CD2 1 
ATOM   473  C CE1 . TYR A 1 59  ? -2.500  -24.170 11.776  1.00 20.30 ? 59  TYR A CE1 1 
ATOM   474  C CE2 . TYR A 1 59  ? -3.325  -24.484 9.537   1.00 19.75 ? 59  TYR A CE2 1 
ATOM   475  C CZ  . TYR A 1 59  ? -3.552  -24.374 10.894  1.00 19.54 ? 59  TYR A CZ  1 
ATOM   476  O OH  . TYR A 1 59  ? -4.845  -24.467 11.380  1.00 17.75 ? 59  TYR A OH  1 
ATOM   477  N N   . TRP A 1 60  ? 0.444   -26.289 7.285   1.00 18.82 ? 60  TRP A N   1 
ATOM   478  C CA  . TRP A 1 60  ? -0.370  -27.186 6.469   1.00 18.41 ? 60  TRP A CA  1 
ATOM   479  C C   . TRP A 1 60  ? 0.215   -28.591 6.422   1.00 17.43 ? 60  TRP A C   1 
ATOM   480  O O   . TRP A 1 60  ? -0.538  -29.572 6.380   1.00 16.33 ? 60  TRP A O   1 
ATOM   481  C CB  . TRP A 1 60  ? -0.545  -26.597 5.071   1.00 17.00 ? 60  TRP A CB  1 
ATOM   482  C CG  . TRP A 1 60  ? -1.275  -25.302 5.167   1.00 19.23 ? 60  TRP A CG  1 
ATOM   483  C CD1 . TRP A 1 60  ? -0.754  -24.050 5.049   1.00 21.72 ? 60  TRP A CD1 1 
ATOM   484  C CD2 . TRP A 1 60  ? -2.661  -25.136 5.467   1.00 18.40 ? 60  TRP A CD2 1 
ATOM   485  N NE1 . TRP A 1 60  ? -1.739  -23.107 5.234   1.00 19.88 ? 60  TRP A NE1 1 
ATOM   486  C CE2 . TRP A 1 60  ? -2.919  -23.753 5.502   1.00 22.21 ? 60  TRP A CE2 1 
ATOM   487  C CE3 . TRP A 1 60  ? -3.714  -26.028 5.697   1.00 15.98 ? 60  TRP A CE3 1 
ATOM   488  C CZ2 . TRP A 1 60  ? -4.192  -23.236 5.759   1.00 21.37 ? 60  TRP A CZ2 1 
ATOM   489  C CZ3 . TRP A 1 60  ? -4.979  -25.511 5.965   1.00 17.39 ? 60  TRP A CZ3 1 
ATOM   490  C CH2 . TRP A 1 60  ? -5.206  -24.131 5.986   1.00 18.28 ? 60  TRP A CH2 1 
ATOM   491  N N   . ASP A 1 61  ? 1.553   -28.711 6.407   1.00 17.23 ? 61  ASP A N   1 
ATOM   492  C CA  . ASP A 1 61  ? 2.176   -30.029 6.513   1.00 17.70 ? 61  ASP A CA  1 
ATOM   493  C C   . ASP A 1 61  ? 1.822   -30.694 7.831   1.00 15.74 ? 61  ASP A C   1 
ATOM   494  O O   . ASP A 1 61  ? 1.470   -31.879 7.875   1.00 14.36 ? 61  ASP A O   1 
ATOM   495  C CB  . ASP A 1 61  ? 3.700   -29.922 6.405   1.00 20.35 ? 61  ASP A CB  1 
ATOM   496  C CG  . ASP A 1 61  ? 4.167   -29.574 5.006   1.00 24.42 ? 61  ASP A CG  1 
ATOM   497  O OD1 . ASP A 1 61  ? 3.351   -29.624 4.059   1.00 20.43 ? 61  ASP A OD1 1 
ATOM   498  O OD2 . ASP A 1 61  ? 5.370   -29.272 4.862   1.00 24.65 ? 61  ASP A OD2 1 
ATOM   499  N N   . GLU A 1 62  ? 1.968   -29.959 8.929   1.00 18.69 ? 62  GLU A N   1 
ATOM   500  C CA  . GLU A 1 62  ? 1.756   -30.563 10.238  1.00 21.89 ? 62  GLU A CA  1 
ATOM   501  C C   . GLU A 1 62  ? 0.281   -30.894 10.456  1.00 15.92 ? 62  GLU A C   1 
ATOM   502  O O   . GLU A 1 62  ? -0.050  -32.000 10.900  1.00 15.83 ? 62  GLU A O   1 
ATOM   503  C CB  . GLU A 1 62  ? 2.281   -29.633 11.331  1.00 23.16 ? 62  GLU A CB  1 
ATOM   504  C CG  . GLU A 1 62  ? 1.773   -29.979 12.713  1.00 26.29 ? 62  GLU A CG  1 
ATOM   505  C CD  . GLU A 1 62  ? 2.666   -30.988 13.421  1.00 33.11 ? 62  GLU A CD  1 
ATOM   506  O OE1 . GLU A 1 62  ? 2.581   -31.090 14.672  1.00 33.20 ? 62  GLU A OE1 1 
ATOM   507  O OE2 . GLU A 1 62  ? 3.462   -31.673 12.735  1.00 34.59 ? 62  GLU A OE2 1 
ATOM   508  N N   . GLU A 1 63  ? -0.626  -29.975 10.108  1.00 17.70 ? 63  GLU A N   1 
ATOM   509  C CA  . GLU A 1 63  ? -2.049  -30.280 10.279  1.00 15.13 ? 63  GLU A CA  1 
ATOM   510  C C   . GLU A 1 63  ? -2.478  -31.437 9.389   1.00 14.79 ? 63  GLU A C   1 
ATOM   511  O O   . GLU A 1 63  ? -3.280  -32.285 9.806   1.00 14.08 ? 63  GLU A O   1 
ATOM   512  C CB  . GLU A 1 63  ? -2.910  -29.047 10.014  1.00 15.00 ? 63  GLU A CB  1 
ATOM   513  C CG  . GLU A 1 63  ? -2.514  -27.872 10.854  1.00 17.48 ? 63  GLU A CG  1 
ATOM   514  C CD  . GLU A 1 63  ? -2.881  -28.054 12.332  1.00 21.35 ? 63  GLU A CD  1 
ATOM   515  O OE1 . GLU A 1 63  ? -3.988  -28.541 12.643  1.00 17.40 ? 63  GLU A OE1 1 
ATOM   516  O OE2 . GLU A 1 63  ? -2.031  -27.741 13.189  1.00 20.95 ? 63  GLU A OE2 1 
ATOM   517  N N   . THR A 1 64  ? -1.957  -31.494 8.158   1.00 11.88 ? 64  THR A N   1 
ATOM   518  C CA  . THR A 1 64  ? -2.220  -32.647 7.301   1.00 14.42 ? 64  THR A CA  1 
ATOM   519  C C   . THR A 1 64  ? -1.755  -33.934 7.959   1.00 14.62 ? 64  THR A C   1 
ATOM   520  O O   . THR A 1 64  ? -2.460  -34.948 7.929   1.00 13.26 ? 64  THR A O   1 
ATOM   521  C CB  . THR A 1 64  ? -1.531  -32.486 5.940   1.00 14.54 ? 64  THR A CB  1 
ATOM   522  O OG1 . THR A 1 64  ? -2.117  -31.399 5.222   1.00 14.56 ? 64  THR A OG1 1 
ATOM   523  C CG2 . THR A 1 64  ? -1.655  -33.761 5.115   1.00 16.87 ? 64  THR A CG2 1 
ATOM   524  N N   . GLY A 1 65  ? -0.551  -33.925 8.535   1.00 14.58 ? 65  GLY A N   1 
ATOM   525  C CA  . GLY A 1 65  ? -0.065  -35.125 9.188   1.00 16.12 ? 65  GLY A CA  1 
ATOM   526  C C   . GLY A 1 65  ? -0.990  -35.571 10.305  1.00 12.08 ? 65  GLY A C   1 
ATOM   527  O O   . GLY A 1 65  ? -1.310  -36.756 10.432  1.00 13.92 ? 65  GLY A O   1 
ATOM   528  N N   . LYS A 1 66  ? -1.428  -34.622 11.130  1.00 11.70 ? 66  LYS A N   1 
ATOM   529  C CA  . LYS A 1 66  ? -2.300  -34.963 12.258  1.00 11.84 ? 66  LYS A CA  1 
ATOM   530  C C   . LYS A 1 66  ? -3.631  -35.529 11.787  1.00 12.21 ? 66  LYS A C   1 
ATOM   531  O O   . LYS A 1 66  ? -4.098  -36.547 12.307  1.00 12.54 ? 66  LYS A O   1 
ATOM   532  C CB  . LYS A 1 66  ? -2.521  -33.739 13.149  1.00 13.62 ? 66  LYS A CB  1 
ATOM   533  C CG  . LYS A 1 66  ? -1.307  -33.412 14.051  1.00 16.62 ? 66  LYS A CG  1 
ATOM   534  C CD  . LYS A 1 66  ? -1.617  -32.282 15.024  1.00 20.91 ? 66  LYS A CD  1 
ATOM   535  C CE  . LYS A 1 66  ? -1.791  -30.943 14.345  1.00 21.94 ? 66  LYS A CE  1 
ATOM   536  N NZ  . LYS A 1 66  ? -1.396  -29.831 15.265  1.00 19.44 ? 66  LYS A NZ  1 
ATOM   537  N N   . VAL A 1 67  ? -4.264  -34.894 10.802  1.00 11.86 ? 67  VAL A N   1 
ATOM   538  C CA  . VAL A 1 67  ? -5.597  -35.377 10.446  1.00 12.33 ? 67  VAL A CA  1 
ATOM   539  C C   . VAL A 1 67  ? -5.503  -36.740 9.755   1.00 12.26 ? 67  VAL A C   1 
ATOM   540  O O   . VAL A 1 67  ? -6.378  -37.596 9.933   1.00 14.53 ? 67  VAL A O   1 
ATOM   541  C CB  . VAL A 1 67  ? -6.348  -34.326 9.604   1.00 12.38 ? 67  VAL A CB  1 
ATOM   542  C CG1 . VAL A 1 67  ? -5.643  -34.054 8.232   1.00 13.27 ? 67  VAL A CG1 1 
ATOM   543  C CG2 . VAL A 1 67  ? -7.820  -34.688 9.465   1.00 15.90 ? 67  VAL A CG2 1 
ATOM   544  N N   . LYS A 1 68  ? -4.441  -36.986 8.981   1.00 14.16 ? 68  LYS A N   1 
ATOM   545  C CA  . LYS A 1 68  ? -4.248  -38.315 8.400   1.00 15.49 ? 68  LYS A CA  1 
ATOM   546  C C   . LYS A 1 68  ? -4.043  -39.384 9.473   1.00 13.47 ? 68  LYS A C   1 
ATOM   547  O O   . LYS A 1 68  ? -4.577  -40.494 9.355   1.00 16.02 ? 68  LYS A O   1 
ATOM   548  C CB  . LYS A 1 68  ? -3.075  -38.308 7.410   1.00 15.27 ? 68  LYS A CB  1 
ATOM   549  C CG  . LYS A 1 68  ? -3.405  -37.595 6.102   1.00 20.03 ? 68  LYS A CG  1 
ATOM   550  C CD  . LYS A 1 68  ? -2.150  -37.314 5.284   1.00 22.17 ? 68  LYS A CD  1 
ATOM   551  C CE  . LYS A 1 68  ? -1.349  -38.565 5.003   1.00 26.82 ? 68  LYS A CE  1 
ATOM   552  N NZ  . LYS A 1 68  ? -0.514  -38.400 3.771   1.00 31.16 ? 68  LYS A NZ  1 
ATOM   553  N N   . ALA A 1 69  ? -3.288  -39.078 10.530  1.00 12.09 ? 69  ALA A N   1 
ATOM   554  C CA  . ALA A 1 69  ? -3.146  -40.037 11.619  1.00 13.44 ? 69  ALA A CA  1 
ATOM   555  C C   . ALA A 1 69  ? -4.490  -40.322 12.291  1.00 13.33 ? 69  ALA A C   1 
ATOM   556  O O   . ALA A 1 69  ? -4.783  -41.466 12.654  1.00 13.34 ? 69  ALA A O   1 
ATOM   557  C CB  . ALA A 1 69  ? -2.146  -39.518 12.648  1.00 13.80 ? 69  ALA A CB  1 
ATOM   558  N N   . HIS A 1 70  ? -5.313  -39.292 12.480  1.00 13.05 ? 70  HIS A N   1 
ATOM   559  C CA  . HIS A 1 70  ? -6.648  -39.521 13.036  1.00 14.19 ? 70  HIS A CA  1 
ATOM   560  C C   . HIS A 1 70  ? -7.454  -40.458 12.150  1.00 13.91 ? 70  HIS A C   1 
ATOM   561  O O   . HIS A 1 70  ? -8.122  -41.374 12.648  1.00 13.84 ? 70  HIS A O   1 
ATOM   562  C CB  . HIS A 1 70  ? -7.395  -38.202 13.208  1.00 12.47 ? 70  HIS A CB  1 
ATOM   563  C CG  . HIS A 1 70  ? -8.687  -38.336 13.959  1.00 14.47 ? 70  HIS A CG  1 
ATOM   564  N ND1 . HIS A 1 70  ? -9.609  -37.315 14.041  1.00 14.28 ? 70  HIS A ND1 1 
ATOM   565  C CD2 . HIS A 1 70  ? -9.190  -39.357 14.694  1.00 16.45 ? 70  HIS A CD2 1 
ATOM   566  C CE1 . HIS A 1 70  ? -10.628 -37.704 14.787  1.00 15.26 ? 70  HIS A CE1 1 
ATOM   567  N NE2 . HIS A 1 70  ? -10.404 -38.942 15.187  1.00 16.65 ? 70  HIS A NE2 1 
ATOM   568  N N   . SER A 1 71  ? -7.408  -40.246 10.833  1.00 13.45 ? 71  SER A N   1 
ATOM   569  C CA  . SER A 1 71  ? -8.186  -41.092 9.928   1.00 13.41 ? 71  SER A CA  1 
ATOM   570  C C   . SER A 1 71  ? -7.815  -42.565 10.079  1.00 18.26 ? 71  SER A C   1 
ATOM   571  O O   . SER A 1 71  ? -8.692  -43.442 10.037  1.00 16.11 ? 71  SER A O   1 
ATOM   572  C CB  . SER A 1 71  ? -7.995  -40.631 8.485   1.00 14.73 ? 71  SER A CB  1 
ATOM   573  O OG  . SER A 1 71  ? -6.718  -41.000 7.992   1.00 18.68 ? 71  SER A OG  1 
ATOM   574  N N   . GLN A 1 72  ? -6.521  -42.857 10.262  1.00 14.50 ? 72  GLN A N   1 
ATOM   575  C CA  . GLN A 1 72  ? -6.073  -44.233 10.458  1.00 16.72 ? 72  GLN A CA  1 
ATOM   576  C C   . GLN A 1 72  ? -6.483  -44.766 11.825  1.00 15.85 ? 72  GLN A C   1 
ATOM   577  O O   . GLN A 1 72  ? -6.859  -45.939 11.955  1.00 18.50 ? 72  GLN A O   1 
ATOM   578  C CB  . GLN A 1 72  ? -4.557  -44.313 10.275  1.00 16.04 ? 72  GLN A CB  1 
ATOM   579  C CG  . GLN A 1 72  ? -4.069  -44.242 8.832   1.00 20.87 ? 72  GLN A CG  1 
ATOM   580  C CD  . GLN A 1 72  ? -4.854  -45.158 7.897   1.00 36.80 ? 72  GLN A CD  1 
ATOM   581  O OE1 . GLN A 1 72  ? -5.345  -44.732 6.843   1.00 41.52 ? 72  GLN A OE1 1 
ATOM   582  N NE2 . GLN A 1 72  ? -4.952  -46.435 8.272   1.00 38.08 ? 72  GLN A NE2 1 
ATOM   583  N N   . THR A 1 73  ? -6.420  -43.929 12.856  1.00 16.10 ? 73  THR A N   1 
ATOM   584  C CA  . THR A 1 73  ? -6.873  -44.355 14.179  1.00 15.32 ? 73  THR A CA  1 
ATOM   585  C C   . THR A 1 73  ? -8.354  -44.731 14.175  1.00 15.02 ? 73  THR A C   1 
ATOM   586  O O   . THR A 1 73  ? -8.735  -45.811 14.640  1.00 15.69 ? 73  THR A O   1 
ATOM   587  C CB  . THR A 1 73  ? -6.579  -43.262 15.206  1.00 16.62 ? 73  THR A CB  1 
ATOM   588  O OG1 . THR A 1 73  ? -5.156  -43.057 15.274  1.00 17.92 ? 73  THR A OG1 1 
ATOM   589  C CG2 . THR A 1 73  ? -7.110  -43.645 16.584  1.00 16.52 ? 73  THR A CG2 1 
ATOM   590  N N   . ASP A 1 74  ? -9.212  -43.857 13.657  1.00 14.34 ? 74  ASP A N   1 
ATOM   591  C CA  . ASP A 1 74  ? -10.627 -44.198 13.716  1.00 17.97 ? 74  ASP A CA  1 
ATOM   592  C C   . ASP A 1 74  ? -11.007 -45.289 12.724  1.00 17.00 ? 74  ASP A C   1 
ATOM   593  O O   . ASP A 1 74  ? -12.000 -45.990 12.947  1.00 17.97 ? 74  ASP A O   1 
ATOM   594  C CB  . ASP A 1 74  ? -11.475 -42.943 13.557  1.00 16.68 ? 74  ASP A CB  1 
ATOM   595  C CG  . ASP A 1 74  ? -11.533 -42.134 14.859  1.00 23.57 ? 74  ASP A CG  1 
ATOM   596  O OD1 . ASP A 1 74  ? -10.875 -42.556 15.856  1.00 22.84 ? 74  ASP A OD1 1 
ATOM   597  O OD2 . ASP A 1 74  ? -12.193 -41.070 14.892  1.00 20.01 ? 74  ASP A OD2 1 
ATOM   598  N N   . ARG A 1 75  ? -10.231 -45.482 11.656  1.00 16.59 ? 75  ARG A N   1 
ATOM   599  C CA  . ARG A 1 75  ? -10.383 -46.696 10.857  1.00 20.44 ? 75  ARG A CA  1 
ATOM   600  C C   . ARG A 1 75  ? -10.260 -47.943 11.732  1.00 18.66 ? 75  ARG A C   1 
ATOM   601  O O   . ARG A 1 75  ? -11.103 -48.847 11.675  1.00 17.79 ? 75  ARG A O   1 
ATOM   602  C CB  . ARG A 1 75  ? -9.337  -46.697 9.740   1.00 19.77 ? 75  ARG A CB  1 
ATOM   603  C CG  . ARG A 1 75  ? -9.601  -47.593 8.571   1.00 28.86 ? 75  ARG A CG  1 
ATOM   604  C CD  . ARG A 1 75  ? -8.483  -47.381 7.549   1.00 38.63 ? 75  ARG A CD  1 
ATOM   605  N NE  . ARG A 1 75  ? -8.611  -46.069 6.922   1.00 45.69 ? 75  ARG A NE  1 
ATOM   606  C CZ  . ARG A 1 75  ? -8.226  -45.779 5.685   1.00 46.80 ? 75  ARG A CZ  1 
ATOM   607  N NH1 . ARG A 1 75  ? -7.458  -46.604 4.989   1.00 49.52 ? 75  ARG A NH1 1 
ATOM   608  N NH2 . ARG A 1 75  ? -8.612  -44.628 5.137   1.00 48.08 ? 75  ARG A NH2 1 
ATOM   609  N N   . GLU A 1 76  ? -9.226  -47.990 12.574  1.00 15.30 ? 76  GLU A N   1 
ATOM   610  C CA  . GLU A 1 76  ? -9.058  -49.119 13.483  1.00 17.71 ? 76  GLU A CA  1 
ATOM   611  C C   . GLU A 1 76  ? -10.161 -49.160 14.530  1.00 17.81 ? 76  GLU A C   1 
ATOM   612  O O   . GLU A 1 76  ? -10.659 -50.236 14.886  1.00 15.88 ? 76  GLU A O   1 
ATOM   613  C CB  . GLU A 1 76  ? -7.696  -49.035 14.163  1.00 22.29 ? 76  GLU A CB  1 
ATOM   614  C CG  . GLU A 1 76  ? -7.255  -50.298 14.902  1.00 27.37 ? 76  GLU A CG  1 
ATOM   615  C CD  . GLU A 1 76  ? -7.647  -51.591 14.199  1.00 34.62 ? 76  GLU A CD  1 
ATOM   616  O OE1 . GLU A 1 76  ? -7.334  -51.747 12.992  1.00 35.64 ? 76  GLU A OE1 1 
ATOM   617  O OE2 . GLU A 1 76  ? -8.253  -52.460 14.873  1.00 33.30 ? 76  GLU A OE2 1 
ATOM   618  N N   . ASN A 1 77  ? -10.553 -47.998 15.040  1.00 14.60 ? 77  ASN A N   1 
ATOM   619  C CA  . ASN A 1 77  ? -11.583 -47.981 16.070  1.00 15.53 ? 77  ASN A CA  1 
ATOM   620  C C   . ASN A 1 77  ? -12.910 -48.533 15.552  1.00 16.29 ? 77  ASN A C   1 
ATOM   621  O O   . ASN A 1 77  ? -13.656 -49.161 16.315  1.00 16.94 ? 77  ASN A O   1 
ATOM   622  C CB  . ASN A 1 77  ? -11.717 -46.564 16.609  1.00 12.78 ? 77  ASN A CB  1 
ATOM   623  C CG  . ASN A 1 77  ? -10.642 -46.246 17.628  1.00 16.29 ? 77  ASN A CG  1 
ATOM   624  O OD1 . ASN A 1 77  ? -10.087 -47.150 18.245  1.00 15.00 ? 77  ASN A OD1 1 
ATOM   625  N ND2 . ASN A 1 77  ? -10.317 -44.973 17.777  1.00 14.86 ? 77  ASN A ND2 1 
ATOM   626  N N   . LEU A 1 78  ? -13.202 -48.356 14.255  1.00 16.63 ? 78  LEU A N   1 
ATOM   627  C CA  . LEU A 1 78  ? -14.421 -48.946 13.690  1.00 17.64 ? 78  LEU A CA  1 
ATOM   628  C C   . LEU A 1 78  ? -14.389 -50.463 13.774  1.00 19.26 ? 78  LEU A C   1 
ATOM   629  O O   . LEU A 1 78  ? -15.408 -51.091 14.077  1.00 23.10 ? 78  LEU A O   1 
ATOM   630  C CB  . LEU A 1 78  ? -14.624 -48.517 12.236  1.00 19.59 ? 78  LEU A CB  1 
ATOM   631  C CG  . LEU A 1 78  ? -15.278 -47.167 11.951  1.00 18.22 ? 78  LEU A CG  1 
ATOM   632  C CD1 . LEU A 1 78  ? -15.014 -46.737 10.508  1.00 19.69 ? 78  LEU A CD1 1 
ATOM   633  C CD2 . LEU A 1 78  ? -16.776 -47.213 12.252  1.00 16.97 ? 78  LEU A CD2 1 
ATOM   634  N N   . ARG A 1 79  ? -13.233 -51.073 13.486  1.00 20.00 ? 79  ARG A N   1 
ATOM   635  C CA  . ARG A 1 79  ? -13.125 -52.526 13.589  1.00 25.06 ? 79  ARG A CA  1 
ATOM   636  C C   . ARG A 1 79  ? -13.240 -53.002 15.031  1.00 22.27 ? 79  ARG A C   1 
ATOM   637  O O   . ARG A 1 79  ? -13.824 -54.057 15.291  1.00 24.21 ? 79  ARG A O   1 
ATOM   638  C CB  . ARG A 1 79  ? -11.819 -53.017 12.972  1.00 24.31 ? 79  ARG A CB  1 
ATOM   639  C CG  . ARG A 1 79  ? -11.549 -52.472 11.604  1.00 27.55 ? 79  ARG A CG  1 
ATOM   640  C CD  . ARG A 1 79  ? -10.215 -52.986 11.094  1.00 33.91 ? 79  ARG A CD  1 
ATOM   641  N NE  . ARG A 1 79  ? -10.413 -54.135 10.217  1.00 53.32 ? 79  ARG A NE  1 
ATOM   642  C CZ  . ARG A 1 79  ? -10.045 -55.380 10.504  1.00 58.29 ? 79  ARG A CZ  1 
ATOM   643  N NH1 . ARG A 1 79  ? -9.355  -55.664 11.600  1.00 51.18 ? 79  ARG A NH1 1 
ATOM   644  N NH2 . ARG A 1 79  ? -10.368 -56.363 9.664   1.00 56.66 ? 79  ARG A NH2 1 
ATOM   645  N N   . ILE A 1 80  ? -12.693 -52.245 15.983  1.00 19.30 ? 80  ILE A N   1 
ATOM   646  C CA  . ILE A 1 80  ? -12.814 -52.629 17.386  1.00 19.57 ? 80  ILE A CA  1 
ATOM   647  C C   . ILE A 1 80  ? -14.265 -52.517 17.851  1.00 20.33 ? 80  ILE A C   1 
ATOM   648  O O   . ILE A 1 80  ? -14.795 -53.421 18.509  1.00 20.53 ? 80  ILE A O   1 
ATOM   649  C CB  . ILE A 1 80  ? -11.869 -51.777 18.249  1.00 17.56 ? 80  ILE A CB  1 
ATOM   650  C CG1 . ILE A 1 80  ? -10.421 -52.007 17.816  1.00 17.76 ? 80  ILE A CG1 1 
ATOM   651  C CG2 . ILE A 1 80  ? -12.024 -52.122 19.746  1.00 20.85 ? 80  ILE A CG2 1 
ATOM   652  C CD1 . ILE A 1 80  ? -9.497  -50.930 18.289  1.00 18.95 ? 80  ILE A CD1 1 
ATOM   653  N N   . ALA A 1 81  ? -14.934 -51.410 17.512  1.00 20.66 ? 81  ALA A N   1 
ATOM   654  C CA  . ALA A 1 81  ? -16.334 -51.255 17.901  1.00 21.41 ? 81  ALA A CA  1 
ATOM   655  C C   . ALA A 1 81  ? -17.181 -52.354 17.287  1.00 23.06 ? 81  ALA A C   1 
ATOM   656  O O   . ALA A 1 81  ? -18.119 -52.859 17.914  1.00 23.13 ? 81  ALA A O   1 
ATOM   657  C CB  . ALA A 1 81  ? -16.855 -49.878 17.480  1.00 18.46 ? 81  ALA A CB  1 
ATOM   658  N N   . LEU A 1 82  ? -16.849 -52.748 16.063  1.00 23.62 ? 82  LEU A N   1 
ATOM   659  C CA  . LEU A 1 82  ? -17.546 -53.856 15.437  1.00 22.85 ? 82  LEU A CA  1 
ATOM   660  C C   . LEU A 1 82  ? -17.445 -55.106 16.299  1.00 25.00 ? 82  LEU A C   1 
ATOM   661  O O   . LEU A 1 82  ? -18.436 -55.812 16.507  1.00 27.74 ? 82  LEU A O   1 
ATOM   662  C CB  . LEU A 1 82  ? -16.960 -54.089 14.049  1.00 23.21 ? 82  LEU A CB  1 
ATOM   663  C CG  . LEU A 1 82  ? -17.776 -54.954 13.111  1.00 31.45 ? 82  LEU A CG  1 
ATOM   664  C CD1 . LEU A 1 82  ? -18.903 -54.091 12.591  1.00 24.35 ? 82  LEU A CD1 1 
ATOM   665  C CD2 . LEU A 1 82  ? -16.895 -55.414 11.982  1.00 33.18 ? 82  LEU A CD2 1 
ATOM   666  N N   . ARG A 1 83  ? -16.265 -55.363 16.861  1.00 26.81 ? 83  ARG A N   1 
ATOM   667  C CA  . ARG A 1 83  ? -16.084 -56.562 17.662  1.00 28.38 ? 83  ARG A CA  1 
ATOM   668  C C   . ARG A 1 83  ? -16.752 -56.423 19.031  1.00 29.57 ? 83  ARG A C   1 
ATOM   669  O O   . ARG A 1 83  ? -17.428 -57.355 19.483  1.00 29.31 ? 83  ARG A O   1 
ATOM   670  C CB  . ARG A 1 83  ? -14.588 -56.867 17.769  1.00 27.45 ? 83  ARG A CB  1 
ATOM   671  C CG  . ARG A 1 83  ? -14.166 -57.779 18.894  1.00 32.24 ? 83  ARG A CG  1 
ATOM   672  C CD  . ARG A 1 83  ? -12.678 -58.110 18.773  1.00 39.73 ? 83  ARG A CD  1 
ATOM   673  N NE  . ARG A 1 83  ? -11.829 -57.212 19.550  1.00 43.37 ? 83  ARG A NE  1 
ATOM   674  C CZ  . ARG A 1 83  ? -10.914 -56.405 19.029  1.00 41.24 ? 83  ARG A CZ  1 
ATOM   675  N NH1 . ARG A 1 83  ? -10.742 -56.310 17.719  1.00 43.28 ? 83  ARG A NH1 1 
ATOM   676  N NH2 . ARG A 1 83  ? -10.158 -55.670 19.843  1.00 41.30 ? 83  ARG A NH2 1 
ATOM   677  N N   . TYR A 1 84  ? -16.616 -55.259 19.685  1.00 25.05 ? 84  TYR A N   1 
ATOM   678  C CA  . TYR A 1 84  ? -17.272 -55.045 20.978  1.00 22.65 ? 84  TYR A CA  1 
ATOM   679  C C   . TYR A 1 84  ? -18.779 -55.254 20.893  1.00 28.85 ? 84  TYR A C   1 
ATOM   680  O O   . TYR A 1 84  ? -19.387 -55.818 21.811  1.00 29.83 ? 84  TYR A O   1 
ATOM   681  C CB  . TYR A 1 84  ? -16.990 -53.637 21.500  1.00 21.21 ? 84  TYR A CB  1 
ATOM   682  C CG  . TYR A 1 84  ? -15.577 -53.405 21.997  1.00 24.42 ? 84  TYR A CG  1 
ATOM   683  C CD1 . TYR A 1 84  ? -14.651 -54.446 22.063  1.00 25.09 ? 84  TYR A CD1 1 
ATOM   684  C CD2 . TYR A 1 84  ? -15.172 -52.145 22.407  1.00 20.17 ? 84  TYR A CD2 1 
ATOM   685  C CE1 . TYR A 1 84  ? -13.353 -54.231 22.516  1.00 21.84 ? 84  TYR A CE1 1 
ATOM   686  C CE2 . TYR A 1 84  ? -13.884 -51.922 22.859  1.00 23.02 ? 84  TYR A CE2 1 
ATOM   687  C CZ  . TYR A 1 84  ? -12.981 -52.968 22.912  1.00 22.19 ? 84  TYR A CZ  1 
ATOM   688  O OH  . TYR A 1 84  ? -11.707 -52.727 23.362  1.00 23.82 ? 84  TYR A OH  1 
ATOM   689  N N   . TYR A 1 85  ? -19.410 -54.783 19.818  1.00 23.04 ? 85  TYR A N   1 
ATOM   690  C CA  . TYR A 1 85  ? -20.857 -54.901 19.671  1.00 25.28 ? 85  TYR A CA  1 
ATOM   691  C C   . TYR A 1 85  ? -21.300 -56.184 18.979  1.00 30.81 ? 85  TYR A C   1 
ATOM   692  O O   . TYR A 1 85  ? -22.506 -56.358 18.748  1.00 30.02 ? 85  TYR A O   1 
ATOM   693  C CB  . TYR A 1 85  ? -21.423 -53.695 18.905  1.00 19.87 ? 85  TYR A CB  1 
ATOM   694  C CG  . TYR A 1 85  ? -21.409 -52.401 19.688  1.00 20.35 ? 85  TYR A CG  1 
ATOM   695  C CD1 . TYR A 1 85  ? -22.381 -52.144 20.641  1.00 23.21 ? 85  TYR A CD1 1 
ATOM   696  C CD2 . TYR A 1 85  ? -20.441 -51.437 19.473  1.00 21.30 ? 85  TYR A CD2 1 
ATOM   697  C CE1 . TYR A 1 85  ? -22.382 -50.978 21.361  1.00 19.65 ? 85  TYR A CE1 1 
ATOM   698  C CE2 . TYR A 1 85  ? -20.443 -50.253 20.189  1.00 20.59 ? 85  TYR A CE2 1 
ATOM   699  C CZ  . TYR A 1 85  ? -21.416 -50.033 21.128  1.00 23.04 ? 85  TYR A CZ  1 
ATOM   700  O OH  . TYR A 1 85  ? -21.429 -48.863 21.847  1.00 25.45 ? 85  TYR A OH  1 
ATOM   701  N N   . ASN A 1 86  ? -20.369 -57.076 18.641  1.00 30.24 ? 86  ASN A N   1 
ATOM   702  C CA  . ASN A 1 86  ? -20.679 -58.328 17.947  1.00 34.64 ? 86  ASN A CA  1 
ATOM   703  C C   . ASN A 1 86  ? -21.529 -58.085 16.698  1.00 30.44 ? 86  ASN A C   1 
ATOM   704  O O   . ASN A 1 86  ? -22.654 -58.569 16.568  1.00 33.15 ? 86  ASN A O   1 
ATOM   705  C CB  . ASN A 1 86  ? -21.370 -59.318 18.887  1.00 35.42 ? 86  ASN A CB  1 
ATOM   706  C CG  . ASN A 1 86  ? -21.115 -60.751 18.491  1.00 39.71 ? 86  ASN A CG  1 
ATOM   707  O OD1 . ASN A 1 86  ? -20.185 -61.037 17.733  1.00 44.21 ? 86  ASN A OD1 1 
ATOM   708  N ND2 . ASN A 1 86  ? -21.944 -61.664 18.988  1.00 43.90 ? 86  ASN A ND2 1 
ATOM   709  N N   . GLN A 1 87  ? -20.966 -57.320 15.768  1.00 30.54 ? 87  GLN A N   1 
ATOM   710  C CA  . GLN A 1 87  ? -21.652 -56.981 14.531  1.00 29.99 ? 87  GLN A CA  1 
ATOM   711  C C   . GLN A 1 87  ? -20.894 -57.566 13.347  1.00 29.53 ? 87  GLN A C   1 
ATOM   712  O O   . GLN A 1 87  ? -19.691 -57.833 13.426  1.00 29.77 ? 87  GLN A O   1 
ATOM   713  C CB  . GLN A 1 87  ? -21.797 -55.461 14.398  1.00 27.79 ? 87  GLN A CB  1 
ATOM   714  C CG  . GLN A 1 87  ? -22.657 -54.841 15.506  1.00 27.60 ? 87  GLN A CG  1 
ATOM   715  C CD  . GLN A 1 87  ? -22.614 -53.330 15.511  1.00 24.84 ? 87  GLN A CD  1 
ATOM   716  O OE1 . GLN A 1 87  ? -21.602 -52.731 15.141  1.00 26.62 ? 87  GLN A OE1 1 
ATOM   717  N NE2 . GLN A 1 87  ? -23.697 -52.700 15.953  1.00 25.27 ? 87  GLN A NE2 1 
ATOM   718  N N   . SER A 1 88  ? -21.613 -57.775 12.245  1.00 31.58 ? 88  SER A N   1 
ATOM   719  C CA  . SER A 1 88  ? -21.024 -58.407 11.073  1.00 36.83 ? 88  SER A CA  1 
ATOM   720  C C   . SER A 1 88  ? -20.199 -57.408 10.266  1.00 37.95 ? 88  SER A C   1 
ATOM   721  O O   . SER A 1 88  ? -20.401 -56.192 10.336  1.00 34.67 ? 88  SER A O   1 
ATOM   722  C CB  . SER A 1 88  ? -22.106 -59.015 10.173  1.00 33.09 ? 88  SER A CB  1 
ATOM   723  O OG  . SER A 1 88  ? -23.123 -58.075 9.903   1.00 39.72 ? 88  SER A OG  1 
ATOM   724  N N   . GLU A 1 89  ? -19.270 -57.942 9.473   1.00 33.23 ? 89  GLU A N   1 
ATOM   725  C CA  . GLU A 1 89  ? -18.503 -57.118 8.550   1.00 34.02 ? 89  GLU A CA  1 
ATOM   726  C C   . GLU A 1 89  ? -19.269 -56.764 7.278   1.00 35.10 ? 89  GLU A C   1 
ATOM   727  O O   . GLU A 1 89  ? -18.667 -56.208 6.359   1.00 39.92 ? 89  GLU A O   1 
ATOM   728  C CB  . GLU A 1 89  ? -17.192 -57.814 8.186   1.00 40.43 ? 89  GLU A CB  1 
ATOM   729  C CG  . GLU A 1 89  ? -16.065 -57.482 9.139   1.00 43.26 ? 89  GLU A CG  1 
ATOM   730  C CD  . GLU A 1 89  ? -15.163 -58.663 9.413   1.00 52.14 ? 89  GLU A CD  1 
ATOM   731  O OE1 . GLU A 1 89  ? -15.685 -59.740 9.783   1.00 53.21 ? 89  GLU A OE1 1 
ATOM   732  O OE2 . GLU A 1 89  ? -13.929 -58.510 9.269   1.00 58.76 ? 89  GLU A OE2 1 
ATOM   733  N N   . ALA A 1 90  ? -20.567 -57.056 7.201   1.00 32.47 ? 90  ALA A N   1 
ATOM   734  C CA  . ALA A 1 90  ? -21.353 -56.734 6.016   1.00 35.21 ? 90  ALA A CA  1 
ATOM   735  C C   . ALA A 1 90  ? -21.892 -55.311 6.025   1.00 35.96 ? 90  ALA A C   1 
ATOM   736  O O   . ALA A 1 90  ? -22.053 -54.709 4.956   1.00 37.06 ? 90  ALA A O   1 
ATOM   737  C CB  . ALA A 1 90  ? -22.527 -57.708 5.878   1.00 35.40 ? 90  ALA A CB  1 
ATOM   738  N N   . GLY A 1 91  ? -22.167 -54.756 7.202   1.00 35.18 ? 91  GLY A N   1 
ATOM   739  C CA  . GLY A 1 91  ? -22.875 -53.503 7.311   1.00 31.20 ? 91  GLY A CA  1 
ATOM   740  C C   . GLY A 1 91  ? -21.967 -52.292 7.433   1.00 27.96 ? 91  GLY A C   1 
ATOM   741  O O   . GLY A 1 91  ? -20.823 -52.373 7.875   1.00 28.04 ? 91  GLY A O   1 
ATOM   742  N N   . SER A 1 92  ? -22.517 -51.158 7.027   1.00 27.82 ? 92  SER A N   1 
ATOM   743  C CA  . SER A 1 92  ? -21.865 -49.864 7.125   1.00 26.75 ? 92  SER A CA  1 
ATOM   744  C C   . SER A 1 92  ? -22.135 -49.243 8.493   1.00 26.18 ? 92  SER A C   1 
ATOM   745  O O   . SER A 1 92  ? -23.267 -49.279 8.994   1.00 24.83 ? 92  SER A O   1 
ATOM   746  C CB  . SER A 1 92  ? -22.385 -48.951 6.011   1.00 26.99 ? 92  SER A CB  1 
ATOM   747  O OG  . SER A 1 92  ? -22.206 -47.575 6.298   1.00 31.03 ? 92  SER A OG  1 
ATOM   748  N N   . HIS A 1 93  ? -21.095 -48.652 9.082   1.00 20.65 ? 93  HIS A N   1 
ATOM   749  C CA  . HIS A 1 93  ? -21.181 -48.075 10.416  1.00 18.16 ? 93  HIS A CA  1 
ATOM   750  C C   . HIS A 1 93  ? -20.447 -46.740 10.471  1.00 16.84 ? 93  HIS A C   1 
ATOM   751  O O   . HIS A 1 93  ? -19.569 -46.453 9.651   1.00 15.36 ? 93  HIS A O   1 
ATOM   752  C CB  . HIS A 1 93  ? -20.601 -49.033 11.454  1.00 21.37 ? 93  HIS A CB  1 
ATOM   753  C CG  . HIS A 1 93  ? -21.394 -50.291 11.607  1.00 23.18 ? 93  HIS A CG  1 
ATOM   754  N ND1 . HIS A 1 93  ? -22.485 -50.381 12.446  1.00 23.43 ? 93  HIS A ND1 1 
ATOM   755  C CD2 . HIS A 1 93  ? -21.268 -51.505 11.015  1.00 23.07 ? 93  HIS A CD2 1 
ATOM   756  C CE1 . HIS A 1 93  ? -22.991 -51.600 12.374  1.00 24.01 ? 93  HIS A CE1 1 
ATOM   757  N NE2 . HIS A 1 93  ? -22.267 -52.304 11.519  1.00 23.31 ? 93  HIS A NE2 1 
ATOM   758  N N   . THR A 1 94  ? -20.810 -45.934 11.470  1.00 13.54 ? 94  THR A N   1 
ATOM   759  C CA  . THR A 1 94  ? -20.368 -44.550 11.592  1.00 15.89 ? 94  THR A CA  1 
ATOM   760  C C   . THR A 1 94  ? -19.667 -44.334 12.924  1.00 14.85 ? 94  THR A C   1 
ATOM   761  O O   . THR A 1 94  ? -20.202 -44.688 13.978  1.00 15.32 ? 94  THR A O   1 
ATOM   762  C CB  . THR A 1 94  ? -21.547 -43.590 11.496  1.00 16.32 ? 94  THR A CB  1 
ATOM   763  O OG1 . THR A 1 94  ? -22.271 -43.874 10.304  1.00 17.46 ? 94  THR A OG1 1 
ATOM   764  C CG2 . THR A 1 94  ? -21.056 -42.153 11.425  1.00 15.43 ? 94  THR A CG2 1 
ATOM   765  N N   . LEU A 1 95  ? -18.501 -43.712 12.888  1.00 13.02 ? 95  LEU A N   1 
ATOM   766  C CA  . LEU A 1 95  ? -17.840 -43.273 14.110  1.00 13.16 ? 95  LEU A CA  1 
ATOM   767  C C   . LEU A 1 95  ? -17.581 -41.783 14.008  1.00 11.96 ? 95  LEU A C   1 
ATOM   768  O O   . LEU A 1 95  ? -16.894 -41.329 13.088  1.00 13.48 ? 95  LEU A O   1 
ATOM   769  C CB  . LEU A 1 95  ? -16.546 -44.048 14.349  1.00 11.24 ? 95  LEU A CB  1 
ATOM   770  C CG  . LEU A 1 95  ? -15.820 -43.612 15.626  1.00 12.38 ? 95  LEU A CG  1 
ATOM   771  C CD1 . LEU A 1 95  ? -16.581 -44.059 16.854  1.00 15.09 ? 95  LEU A CD1 1 
ATOM   772  C CD2 . LEU A 1 95  ? -14.451 -44.259 15.639  1.00 15.64 ? 95  LEU A CD2 1 
ATOM   773  N N   . GLN A 1 96  ? -18.141 -41.022 14.934  1.00 9.62  ? 96  GLN A N   1 
ATOM   774  C CA  . GLN A 1 96  ? -17.926 -39.588 14.951  1.00 9.47  ? 96  GLN A CA  1 
ATOM   775  C C   . GLN A 1 96  ? -17.105 -39.199 16.165  1.00 11.78 ? 96  GLN A C   1 
ATOM   776  O O   . GLN A 1 96  ? -17.229 -39.799 17.233  1.00 10.64 ? 96  GLN A O   1 
ATOM   777  C CB  . GLN A 1 96  ? -19.242 -38.824 14.975  1.00 11.07 ? 96  GLN A CB  1 
ATOM   778  C CG  . GLN A 1 96  ? -20.068 -38.969 13.723  1.00 14.09 ? 96  GLN A CG  1 
ATOM   779  C CD  . GLN A 1 96  ? -21.529 -38.668 14.008  1.00 12.68 ? 96  GLN A CD  1 
ATOM   780  O OE1 . GLN A 1 96  ? -22.315 -39.549 14.369  1.00 14.01 ? 96  GLN A OE1 1 
ATOM   781  N NE2 . GLN A 1 96  ? -21.874 -37.403 13.917  1.00 11.39 ? 96  GLN A NE2 1 
ATOM   782  N N   . MET A 1 97  ? -16.260 -38.186 15.987  1.00 13.16 ? 97  MET A N   1 
ATOM   783  C CA  . MET A 1 97  ? -15.474 -37.605 17.069  1.00 12.50 ? 97  MET A CA  1 
ATOM   784  C C   . MET A 1 97  ? -15.653 -36.100 17.071  1.00 12.16 ? 97  MET A C   1 
ATOM   785  O O   . MET A 1 97  ? -15.655 -35.470 16.009  1.00 12.97 ? 97  MET A O   1 
ATOM   786  C CB  . MET A 1 97  ? -13.995 -37.887 16.944  1.00 12.68 ? 97  MET A CB  1 
ATOM   787  C CG  . MET A 1 97  ? -13.285 -37.455 18.229  1.00 16.65 ? 97  MET A CG  1 
ATOM   788  S SD  . MET A 1 97  ? -11.566 -37.764 18.180  1.00 20.62 ? 97  MET A SD  1 
ATOM   789  C CE  . MET A 1 97  ? -11.101 -37.309 19.850  1.00 19.75 ? 97  MET A CE  1 
ATOM   790  N N   . MET A 1 98  ? -15.802 -35.519 18.262  1.00 10.96 ? 98  MET A N   1 
ATOM   791  C CA  . MET A 1 98  ? -15.667 -34.080 18.407  1.00 10.62 ? 98  MET A CA  1 
ATOM   792  C C   . MET A 1 98  ? -14.651 -33.779 19.503  1.00 12.43 ? 98  MET A C   1 
ATOM   793  O O   . MET A 1 98  ? -14.572 -34.496 20.504  1.00 12.01 ? 98  MET A O   1 
ATOM   794  C CB  . MET A 1 98  ? -17.057 -33.446 18.604  1.00 13.93 ? 98  MET A CB  1 
ATOM   795  C CG  . MET A 1 98  ? -17.175 -31.990 19.026  1.00 14.71 ? 98  MET A CG  1 
ATOM   796  S SD  . MET A 1 98  ? -16.423 -31.392 20.539  1.00 25.50 ? 98  MET A SD  1 
ATOM   797  C CE  . MET A 1 98  ? -17.920 -31.442 21.566  1.00 21.34 ? 98  MET A CE  1 
ATOM   798  N N   . PHE A 1 99  ? -13.812 -32.771 19.262  1.00 8.41  ? 99  PHE A N   1 
ATOM   799  C CA  . PHE A 1 99  ? -12.890 -32.307 20.301  1.00 12.61 ? 99  PHE A CA  1 
ATOM   800  C C   . PHE A 1 99  ? -12.625 -30.819 20.114  1.00 11.04 ? 99  PHE A C   1 
ATOM   801  O O   . PHE A 1 99  ? -12.866 -30.256 19.043  1.00 9.72  ? 99  PHE A O   1 
ATOM   802  C CB  . PHE A 1 99  ? -11.579 -33.127 20.329  1.00 7.56  ? 99  PHE A CB  1 
ATOM   803  C CG  . PHE A 1 99  ? -10.730 -33.023 19.077  1.00 9.37  ? 99  PHE A CG  1 
ATOM   804  C CD1 . PHE A 1 99  ? -9.828  -31.989 18.921  1.00 10.44 ? 99  PHE A CD1 1 
ATOM   805  C CD2 . PHE A 1 99  ? -10.820 -33.980 18.079  1.00 11.46 ? 99  PHE A CD2 1 
ATOM   806  C CE1 . PHE A 1 99  ? -9.021  -31.901 17.779  1.00 13.14 ? 99  PHE A CE1 1 
ATOM   807  C CE2 . PHE A 1 99  ? -10.033 -33.896 16.930  1.00 11.48 ? 99  PHE A CE2 1 
ATOM   808  C CZ  . PHE A 1 99  ? -9.132  -32.853 16.785  1.00 14.24 ? 99  PHE A CZ  1 
ATOM   809  N N   . GLY A 1 100 ? -12.151 -30.178 21.180  1.00 12.32 ? 100 GLY A N   1 
ATOM   810  C CA  . GLY A 1 100 ? -11.799 -28.770 21.114  1.00 12.37 ? 100 GLY A CA  1 
ATOM   811  C C   . GLY A 1 100 ? -11.980 -28.106 22.467  1.00 14.43 ? 100 GLY A C   1 
ATOM   812  O O   . GLY A 1 100 ? -11.963 -28.767 23.498  1.00 14.44 ? 100 GLY A O   1 
ATOM   813  N N   . CYS A 1 101 ? -12.161 -26.786 22.450  1.00 12.54 ? 101 CYS A N   1 
ATOM   814  C CA  . CYS A 1 101 ? -12.133 -26.062 23.714  1.00 17.36 ? 101 CYS A CA  1 
ATOM   815  C C   . CYS A 1 101 ? -12.954 -24.786 23.629  1.00 18.08 ? 101 CYS A C   1 
ATOM   816  O O   . CYS A 1 101 ? -13.163 -24.225 22.548  1.00 16.42 ? 101 CYS A O   1 
ATOM   817  C CB  . CYS A 1 101 ? -10.696 -25.714 24.120  1.00 15.28 ? 101 CYS A CB  1 
ATOM   818  S SG  . CYS A 1 101 ? -9.749  -24.861 22.806  1.00 22.83 ? 101 CYS A SG  1 
ATOM   819  N N   . ASP A 1 102 ? -13.417 -24.340 24.801  1.00 17.84 ? 102 ASP A N   1 
ATOM   820  C CA  . ASP A 1 102 ? -14.066 -23.050 24.998  1.00 19.06 ? 102 ASP A CA  1 
ATOM   821  C C   . ASP A 1 102 ? -13.114 -22.134 25.759  1.00 18.45 ? 102 ASP A C   1 
ATOM   822  O O   . ASP A 1 102 ? -12.440 -22.582 26.689  1.00 18.80 ? 102 ASP A O   1 
ATOM   823  C CB  . ASP A 1 102 ? -15.356 -23.191 25.817  1.00 20.61 ? 102 ASP A CB  1 
ATOM   824  C CG  . ASP A 1 102 ? -16.412 -24.048 25.139  1.00 22.96 ? 102 ASP A CG  1 
ATOM   825  O OD1 . ASP A 1 102 ? -16.309 -24.295 23.918  1.00 22.12 ? 102 ASP A OD1 1 
ATOM   826  O OD2 . ASP A 1 102 ? -17.349 -24.488 25.849  1.00 23.52 ? 102 ASP A OD2 1 
ATOM   827  N N   . VAL A 1 103 ? -13.068 -20.851 25.378  1.00 17.51 ? 103 VAL A N   1 
ATOM   828  C CA  . VAL A 1 103 ? -12.281 -19.857 26.104  1.00 20.67 ? 103 VAL A CA  1 
ATOM   829  C C   . VAL A 1 103 ? -13.211 -18.714 26.479  1.00 23.32 ? 103 VAL A C   1 
ATOM   830  O O   . VAL A 1 103 ? -14.203 -18.449 25.792  1.00 22.41 ? 103 VAL A O   1 
ATOM   831  C CB  . VAL A 1 103 ? -11.084 -19.309 25.296  1.00 24.08 ? 103 VAL A CB  1 
ATOM   832  C CG1 . VAL A 1 103 ? -10.030 -20.398 25.079  1.00 20.38 ? 103 VAL A CG1 1 
ATOM   833  C CG2 . VAL A 1 103 ? -11.535 -18.635 23.998  1.00 23.18 ? 103 VAL A CG2 1 
ATOM   834  N N   . GLY A 1 104 ? -12.892 -18.031 27.572  1.00 24.17 ? 104 GLY A N   1 
ATOM   835  C CA  . GLY A 1 104 ? -13.675 -16.889 27.992  1.00 23.84 ? 104 GLY A CA  1 
ATOM   836  C C   . GLY A 1 104 ? -13.272 -15.630 27.251  1.00 29.47 ? 104 GLY A C   1 
ATOM   837  O O   . GLY A 1 104 ? -12.358 -15.625 26.423  1.00 30.65 ? 104 GLY A O   1 
ATOM   838  N N   . SER A 1 105 ? -13.992 -14.540 27.552  1.00 31.90 ? 105 SER A N   1 
ATOM   839  C CA  . SER A 1 105 ? -13.615 -13.228 27.029  1.00 32.80 ? 105 SER A CA  1 
ATOM   840  C C   . SER A 1 105 ? -12.190 -12.902 27.417  1.00 37.38 ? 105 SER A C   1 
ATOM   841  O O   . SER A 1 105 ? -11.444 -12.292 26.641  1.00 39.90 ? 105 SER A O   1 
ATOM   842  C CB  . SER A 1 105 ? -14.561 -12.158 27.561  1.00 34.72 ? 105 SER A CB  1 
ATOM   843  O OG  . SER A 1 105 ? -15.874 -12.679 27.689  1.00 44.99 ? 105 SER A OG  1 
ATOM   844  N N   . ASP A 1 106 ? -11.813 -13.298 28.631  1.00 38.11 ? 106 ASP A N   1 
ATOM   845  C CA  . ASP A 1 106 ? -10.449 -13.380 29.128  1.00 40.02 ? 106 ASP A CA  1 
ATOM   846  C C   . ASP A 1 106 ? -9.468  -13.880 28.081  1.00 37.06 ? 106 ASP A C   1 
ATOM   847  O O   . ASP A 1 106 ? -8.343  -13.384 27.978  1.00 37.06 ? 106 ASP A O   1 
ATOM   848  C CB  . ASP A 1 106 ? -10.426 -14.326 30.331  1.00 38.62 ? 106 ASP A CB  1 
ATOM   849  C CG  . ASP A 1 106 ? -9.421  -13.918 31.371  1.00 52.23 ? 106 ASP A CG  1 
ATOM   850  O OD1 . ASP A 1 106 ? -8.355  -13.394 30.980  1.00 57.35 ? 106 ASP A OD1 1 
ATOM   851  O OD2 . ASP A 1 106 ? -9.690  -14.126 32.578  1.00 58.99 ? 106 ASP A OD2 1 
ATOM   852  N N   . GLY A 1 107 ? -9.880  -14.878 27.311  1.00 37.97 ? 107 GLY A N   1 
ATOM   853  C CA  . GLY A 1 107 ? -8.960  -15.648 26.505  1.00 34.86 ? 107 GLY A CA  1 
ATOM   854  C C   . GLY A 1 107 ? -8.492  -16.925 27.167  1.00 30.42 ? 107 GLY A C   1 
ATOM   855  O O   . GLY A 1 107 ? -7.777  -17.707 26.530  1.00 30.79 ? 107 GLY A O   1 
ATOM   856  N N   . ARG A 1 108 ? -8.892  -17.175 28.411  1.00 28.45 ? 108 ARG A N   1 
ATOM   857  C CA  . ARG A 1 108 ? -8.368  -18.298 29.174  1.00 32.40 ? 108 ARG A CA  1 
ATOM   858  C C   . ARG A 1 108 ? -9.302  -19.498 29.108  1.00 25.74 ? 108 ARG A C   1 
ATOM   859  O O   . ARG A 1 108 ? -10.484 -19.389 28.771  1.00 24.20 ? 108 ARG A O   1 
ATOM   860  C CB  . ARG A 1 108 ? -8.117  -17.906 30.633  1.00 35.38 ? 108 ARG A CB  1 
ATOM   861  C CG  . ARG A 1 108 ? -7.341  -16.599 30.800  1.00 42.38 ? 108 ARG A CG  1 
ATOM   862  C CD  . ARG A 1 108 ? -6.805  -16.430 32.229  1.00 49.98 ? 108 ARG A CD  1 
ATOM   863  N NE  . ARG A 1 108 ? -5.348  -16.535 32.291  1.00 55.75 ? 108 ARG A NE  1 
ATOM   864  C CZ  . ARG A 1 108 ? -4.677  -17.669 32.447  1.00 58.24 ? 108 ARG A CZ  1 
ATOM   865  N NH1 . ARG A 1 108 ? -5.297  -18.840 32.509  1.00 51.66 ? 108 ARG A NH1 1 
ATOM   866  N NH2 . ARG A 1 108 ? -3.348  -17.631 32.526  1.00 54.88 ? 108 ARG A NH2 1 
ATOM   867  N N   . PHE A 1 109 ? -8.738  -20.656 29.434  1.00 22.92 ? 109 PHE A N   1 
ATOM   868  C CA  . PHE A 1 109 ? -9.427  -21.921 29.243  1.00 21.10 ? 109 PHE A CA  1 
ATOM   869  C C   . PHE A 1 109 ? -10.681 -21.996 30.098  1.00 23.47 ? 109 PHE A C   1 
ATOM   870  O O   . PHE A 1 109 ? -10.656 -21.678 31.288  1.00 21.83 ? 109 PHE A O   1 
ATOM   871  C CB  . PHE A 1 109 ? -8.486  -23.069 29.587  1.00 21.05 ? 109 PHE A CB  1 
ATOM   872  C CG  . PHE A 1 109 ? -9.129  -24.427 29.540  1.00 23.79 ? 109 PHE A CG  1 
ATOM   873  C CD1 . PHE A 1 109 ? -9.263  -25.103 28.334  1.00 21.04 ? 109 PHE A CD1 1 
ATOM   874  C CD2 . PHE A 1 109 ? -9.561  -25.050 30.705  1.00 23.03 ? 109 PHE A CD2 1 
ATOM   875  C CE1 . PHE A 1 109 ? -9.830  -26.367 28.287  1.00 17.82 ? 109 PHE A CE1 1 
ATOM   876  C CE2 . PHE A 1 109 ? -10.129 -26.308 30.660  1.00 24.52 ? 109 PHE A CE2 1 
ATOM   877  C CZ  . PHE A 1 109 ? -10.263 -26.968 29.450  1.00 19.91 ? 109 PHE A CZ  1 
ATOM   878  N N   . LEU A 1 110 ? -11.780 -22.434 29.490  1.00 19.53 ? 110 LEU A N   1 
ATOM   879  C CA  . LEU A 1 110 ? -13.034 -22.662 30.203  1.00 20.99 ? 110 LEU A CA  1 
ATOM   880  C C   . LEU A 1 110 ? -13.455 -24.123 30.215  1.00 21.51 ? 110 LEU A C   1 
ATOM   881  O O   . LEU A 1 110 ? -13.878 -24.636 31.255  1.00 23.59 ? 110 LEU A O   1 
ATOM   882  C CB  . LEU A 1 110 ? -14.157 -21.839 29.572  1.00 23.10 ? 110 LEU A CB  1 
ATOM   883  C CG  . LEU A 1 110 ? -14.366 -20.379 29.966  1.00 24.70 ? 110 LEU A CG  1 
ATOM   884  C CD1 . LEU A 1 110 ? -15.517 -19.830 29.138  1.00 20.77 ? 110 LEU A CD1 1 
ATOM   885  C CD2 . LEU A 1 110 ? -14.632 -20.238 31.456  1.00 28.09 ? 110 LEU A CD2 1 
ATOM   886  N N   . ARG A 1 111 ? -13.341 -24.812 29.083  1.00 19.89 ? 111 ARG A N   1 
ATOM   887  C CA  . ARG A 1 111 ? -13.824 -26.183 28.960  1.00 19.59 ? 111 ARG A CA  1 
ATOM   888  C C   . ARG A 1 111 ? -13.071 -26.854 27.819  1.00 20.73 ? 111 ARG A C   1 
ATOM   889  O O   . ARG A 1 111 ? -12.648 -26.187 26.869  1.00 16.49 ? 111 ARG A O   1 
ATOM   890  C CB  . ARG A 1 111 ? -15.332 -26.222 28.687  1.00 24.72 ? 111 ARG A CB  1 
ATOM   891  C CG  . ARG A 1 111 ? -15.877 -27.630 28.514  1.00 29.92 ? 111 ARG A CG  1 
ATOM   892  C CD  . ARG A 1 111 ? -16.529 -28.225 29.756  1.00 32.97 ? 111 ARG A CD  1 
ATOM   893  N NE  . ARG A 1 111 ? -17.482 -29.249 29.344  1.00 34.43 ? 111 ARG A NE  1 
ATOM   894  C CZ  . ARG A 1 111 ? -18.785 -29.218 29.580  1.00 41.01 ? 111 ARG A CZ  1 
ATOM   895  N NH1 . ARG A 1 111 ? -19.345 -28.212 30.236  1.00 43.67 ? 111 ARG A NH1 1 
ATOM   896  N NH2 . ARG A 1 111 ? -19.551 -30.208 29.120  1.00 43.95 ? 111 ARG A NH2 1 
ATOM   897  N N   . GLY A 1 112 ? -12.902 -28.169 27.931  1.00 16.12 ? 112 GLY A N   1 
ATOM   898  C CA  . GLY A 1 112 ? -12.338 -28.960 26.854  1.00 17.19 ? 112 GLY A CA  1 
ATOM   899  C C   . GLY A 1 112 ? -13.198 -30.174 26.574  1.00 18.75 ? 112 GLY A C   1 
ATOM   900  O O   . GLY A 1 112 ? -13.887 -30.691 27.453  1.00 19.58 ? 112 GLY A O   1 
ATOM   901  N N   . TYR A 1 113 ? -13.153 -30.626 25.323  1.00 15.65 ? 113 TYR A N   1 
ATOM   902  C CA  . TYR A 1 113 ? -14.026 -31.695 24.850  1.00 13.13 ? 113 TYR A CA  1 
ATOM   903  C C   . TYR A 1 113 ? -13.228 -32.713 24.059  1.00 12.87 ? 113 TYR A C   1 
ATOM   904  O O   . TYR A 1 113 ? -12.325 -32.347 23.305  1.00 11.87 ? 113 TYR A O   1 
ATOM   905  C CB  . TYR A 1 113 ? -15.147 -31.167 23.940  1.00 14.19 ? 113 TYR A CB  1 
ATOM   906  C CG  . TYR A 1 113 ? -15.981 -30.092 24.570  1.00 18.72 ? 113 TYR A CG  1 
ATOM   907  C CD1 . TYR A 1 113 ? -17.074 -30.408 25.368  1.00 21.27 ? 113 TYR A CD1 1 
ATOM   908  C CD2 . TYR A 1 113 ? -15.671 -28.751 24.379  1.00 21.40 ? 113 TYR A CD2 1 
ATOM   909  C CE1 . TYR A 1 113 ? -17.840 -29.416 25.954  1.00 26.34 ? 113 TYR A CE1 1 
ATOM   910  C CE2 . TYR A 1 113 ? -16.425 -27.756 24.961  1.00 22.16 ? 113 TYR A CE2 1 
ATOM   911  C CZ  . TYR A 1 113 ? -17.511 -28.092 25.738  1.00 24.89 ? 113 TYR A CZ  1 
ATOM   912  O OH  . TYR A 1 113 ? -18.247 -27.087 26.314  1.00 26.67 ? 113 TYR A OH  1 
ATOM   913  N N   . HIS A 1 114 ? -13.632 -33.979 24.186  1.00 12.05 ? 114 HIS A N   1 
ATOM   914  C CA  . HIS A 1 114 ? -12.965 -35.115 23.548  1.00 12.68 ? 114 HIS A CA  1 
ATOM   915  C C   . HIS A 1 114 ? -13.979 -36.265 23.635  1.00 14.74 ? 114 HIS A C   1 
ATOM   916  O O   . HIS A 1 114 ? -14.036 -36.956 24.652  1.00 11.40 ? 114 HIS A O   1 
ATOM   917  C CB  . HIS A 1 114 ? -11.669 -35.429 24.288  1.00 11.87 ? 114 HIS A CB  1 
ATOM   918  C CG  . HIS A 1 114 ? -10.805 -36.470 23.647  1.00 17.40 ? 114 HIS A CG  1 
ATOM   919  N ND1 . HIS A 1 114 ? -9.705  -36.149 22.878  1.00 16.06 ? 114 HIS A ND1 1 
ATOM   920  C CD2 . HIS A 1 114 ? -10.830 -37.825 23.717  1.00 17.86 ? 114 HIS A CD2 1 
ATOM   921  C CE1 . HIS A 1 114 ? -9.104  -37.258 22.484  1.00 17.93 ? 114 HIS A CE1 1 
ATOM   922  N NE2 . HIS A 1 114 ? -9.761  -38.289 22.985  1.00 18.46 ? 114 HIS A NE2 1 
ATOM   923  N N   . GLN A 1 115 ? -14.816 -36.427 22.600  1.00 11.72 ? 115 GLN A N   1 
ATOM   924  C CA  . GLN A 1 115 ? -15.920 -37.375 22.721  1.00 14.11 ? 115 GLN A CA  1 
ATOM   925  C C   . GLN A 1 115 ? -16.212 -38.071 21.400  1.00 12.74 ? 115 GLN A C   1 
ATOM   926  O O   . GLN A 1 115 ? -15.925 -37.552 20.316  1.00 11.59 ? 115 GLN A O   1 
ATOM   927  C CB  . GLN A 1 115 ? -17.210 -36.707 23.194  1.00 13.02 ? 115 GLN A CB  1 
ATOM   928  C CG  . GLN A 1 115 ? -17.405 -35.303 22.648  1.00 14.85 ? 115 GLN A CG  1 
ATOM   929  C CD  . GLN A 1 115 ? -18.506 -34.551 23.362  1.00 17.75 ? 115 GLN A CD  1 
ATOM   930  O OE1 . GLN A 1 115 ? -19.576 -34.291 22.796  1.00 19.56 ? 115 GLN A OE1 1 
ATOM   931  N NE2 . GLN A 1 115 ? -18.267 -34.228 24.614  1.00 13.16 ? 115 GLN A NE2 1 
ATOM   932  N N   . TYR A 1 116 ? -16.795 -39.262 21.510  1.00 14.20 ? 116 TYR A N   1 
ATOM   933  C CA  . TYR A 1 116 ? -17.066 -40.121 20.373  1.00 12.60 ? 116 TYR A CA  1 
ATOM   934  C C   . TYR A 1 116 ? -18.529 -40.536 20.361  1.00 12.68 ? 116 TYR A C   1 
ATOM   935  O O   . TYR A 1 116 ? -19.159 -40.669 21.409  1.00 12.37 ? 116 TYR A O   1 
ATOM   936  C CB  . TYR A 1 116 ? -16.249 -41.410 20.384  1.00 15.68 ? 116 TYR A CB  1 
ATOM   937  C CG  . TYR A 1 116 ? -14.752 -41.251 20.244  1.00 17.69 ? 116 TYR A CG  1 
ATOM   938  C CD1 . TYR A 1 116 ? -13.984 -40.822 21.316  1.00 20.10 ? 116 TYR A CD1 1 
ATOM   939  C CD2 . TYR A 1 116 ? -14.125 -41.455 19.015  1.00 21.10 ? 116 TYR A CD2 1 
ATOM   940  C CE1 . TYR A 1 116 ? -12.615 -40.676 21.200  1.00 22.20 ? 116 TYR A CE1 1 
ATOM   941  C CE2 . TYR A 1 116 ? -12.751 -41.295 18.879  1.00 20.66 ? 116 TYR A CE2 1 
ATOM   942  C CZ  . TYR A 1 116 ? -12.004 -40.908 19.989  1.00 23.22 ? 116 TYR A CZ  1 
ATOM   943  O OH  . TYR A 1 116 ? -10.635 -40.733 19.896  1.00 33.84 ? 116 TYR A OH  1 
ATOM   944  N N   . ALA A 1 117 ? -19.037 -40.786 19.162  1.00 13.44 ? 117 ALA A N   1 
ATOM   945  C CA  . ALA A 1 117 ? -20.331 -41.425 18.948  1.00 11.93 ? 117 ALA A CA  1 
ATOM   946  C C   . ALA A 1 117 ? -20.167 -42.566 17.959  1.00 13.79 ? 117 ALA A C   1 
ATOM   947  O O   . ALA A 1 117 ? -19.451 -42.431 16.960  1.00 13.98 ? 117 ALA A O   1 
ATOM   948  C CB  . ALA A 1 117 ? -21.373 -40.447 18.420  1.00 12.95 ? 117 ALA A CB  1 
ATOM   949  N N   . TYR A 1 118 ? -20.838 -43.683 18.237  1.00 13.30 ? 118 TYR A N   1 
ATOM   950  C CA  . TYR A 1 118 ? -20.886 -44.839 17.349  1.00 13.65 ? 118 TYR A CA  1 
ATOM   951  C C   . TYR A 1 118 ? -22.305 -44.991 16.814  1.00 13.92 ? 118 TYR A C   1 
ATOM   952  O O   . TYR A 1 118 ? -23.264 -45.005 17.595  1.00 16.43 ? 118 TYR A O   1 
ATOM   953  C CB  . TYR A 1 118 ? -20.483 -46.118 18.083  1.00 15.11 ? 118 TYR A CB  1 
ATOM   954  C CG  . TYR A 1 118 ? -20.285 -47.308 17.176  1.00 14.96 ? 118 TYR A CG  1 
ATOM   955  C CD1 . TYR A 1 118 ? -19.411 -47.258 16.099  1.00 15.64 ? 118 TYR A CD1 1 
ATOM   956  C CD2 . TYR A 1 118 ? -21.036 -48.464 17.359  1.00 17.06 ? 118 TYR A CD2 1 
ATOM   957  C CE1 . TYR A 1 118 ? -19.244 -48.360 15.260  1.00 18.07 ? 118 TYR A CE1 1 
ATOM   958  C CE2 . TYR A 1 118 ? -20.888 -49.561 16.528  1.00 17.98 ? 118 TYR A CE2 1 
ATOM   959  C CZ  . TYR A 1 118 ? -19.995 -49.503 15.479  1.00 19.57 ? 118 TYR A CZ  1 
ATOM   960  O OH  . TYR A 1 118 ? -19.857 -50.598 14.655  1.00 19.85 ? 118 TYR A OH  1 
ATOM   961  N N   . ASP A 1 119 ? -22.432 -45.124 15.495  1.00 14.77 ? 119 ASP A N   1 
ATOM   962  C CA  . ASP A 1 119 ? -23.741 -45.236 14.849  1.00 18.28 ? 119 ASP A CA  1 
ATOM   963  C C   . ASP A 1 119 ? -24.762 -44.247 15.403  1.00 18.40 ? 119 ASP A C   1 
ATOM   964  O O   . ASP A 1 119 ? -25.917 -44.613 15.646  1.00 20.32 ? 119 ASP A O   1 
ATOM   965  C CB  . ASP A 1 119 ? -24.275 -46.668 14.967  1.00 19.38 ? 119 ASP A CB  1 
ATOM   966  C CG  . ASP A 1 119 ? -23.570 -47.628 14.018  1.00 20.60 ? 119 ASP A CG  1 
ATOM   967  O OD1 . ASP A 1 119 ? -23.069 -47.151 12.967  1.00 20.76 ? 119 ASP A OD1 1 
ATOM   968  O OD2 . ASP A 1 119 ? -23.524 -48.852 14.300  1.00 22.64 ? 119 ASP A OD2 1 
ATOM   969  N N   . GLY A 1 120 ? -24.342 -43.000 15.615  1.00 14.26 ? 120 GLY A N   1 
ATOM   970  C CA  . GLY A 1 120 ? -25.229 -41.905 15.957  1.00 17.71 ? 120 GLY A CA  1 
ATOM   971  C C   . GLY A 1 120 ? -25.572 -41.760 17.419  1.00 18.39 ? 120 GLY A C   1 
ATOM   972  O O   . GLY A 1 120 ? -26.373 -40.883 17.765  1.00 19.47 ? 120 GLY A O   1 
ATOM   973  N N   . LYS A 1 121 ? -24.997 -42.578 18.289  1.00 16.84 ? 121 LYS A N   1 
ATOM   974  C CA  . LYS A 1 121 ? -25.295 -42.535 19.712  1.00 19.89 ? 121 LYS A CA  1 
ATOM   975  C C   . LYS A 1 121 ? -23.989 -42.366 20.479  1.00 18.06 ? 121 LYS A C   1 
ATOM   976  O O   . LYS A 1 121 ? -22.933 -42.817 20.020  1.00 14.25 ? 121 LYS A O   1 
ATOM   977  C CB  . LYS A 1 121 ? -26.021 -43.814 20.151  1.00 21.84 ? 121 LYS A CB  1 
ATOM   978  C CG  . LYS A 1 121 ? -26.742 -43.714 21.490  1.00 28.96 ? 121 LYS A CG  1 
ATOM   979  C CD  . LYS A 1 121 ? -27.222 -45.090 21.968  1.00 32.77 ? 121 LYS A CD  1 
ATOM   980  C CE  . LYS A 1 121 ? -26.064 -46.019 22.242  1.00 32.24 ? 121 LYS A CE  1 
ATOM   981  N NZ  . LYS A 1 121 ? -25.099 -45.367 23.173  1.00 30.80 ? 121 LYS A NZ  1 
ATOM   982  N N   . ASP A 1 122 ? -24.063 -41.698 21.638  1.00 15.49 ? 122 ASP A N   1 
ATOM   983  C CA  . ASP A 1 122 ? -22.882 -41.533 22.483  1.00 15.92 ? 122 ASP A CA  1 
ATOM   984  C C   . ASP A 1 122 ? -22.148 -42.854 22.618  1.00 15.47 ? 122 ASP A C   1 
ATOM   985  O O   . ASP A 1 122 ? -22.772 -43.907 22.793  1.00 14.59 ? 122 ASP A O   1 
ATOM   986  C CB  . ASP A 1 122 ? -23.244 -41.068 23.900  1.00 16.80 ? 122 ASP A CB  1 
ATOM   987  C CG  . ASP A 1 122 ? -23.572 -39.594 23.996  1.00 24.63 ? 122 ASP A CG  1 
ATOM   988  O OD1 . ASP A 1 122 ? -23.040 -38.791 23.213  1.00 25.51 ? 122 ASP A OD1 1 
ATOM   989  O OD2 . ASP A 1 122 ? -24.255 -39.214 24.972  1.00 23.72 ? 122 ASP A OD2 1 
ATOM   990  N N   . TYR A 1 123 ? -20.813 -42.793 22.561  1.00 15.63 ? 123 TYR A N   1 
ATOM   991  C CA  . TYR A 1 123 ? -19.966 -43.933 22.880  1.00 13.91 ? 123 TYR A CA  1 
ATOM   992  C C   . TYR A 1 123 ? -19.182 -43.616 24.169  1.00 15.16 ? 123 TYR A C   1 
ATOM   993  O O   . TYR A 1 123 ? -19.533 -44.115 25.235  1.00 15.34 ? 123 TYR A O   1 
ATOM   994  C CB  . TYR A 1 123 ? -19.028 -44.284 21.710  1.00 15.80 ? 123 TYR A CB  1 
ATOM   995  C CG  . TYR A 1 123 ? -18.155 -45.499 21.979  1.00 16.78 ? 123 TYR A CG  1 
ATOM   996  C CD1 . TYR A 1 123 ? -18.667 -46.784 21.840  1.00 19.77 ? 123 TYR A CD1 1 
ATOM   997  C CD2 . TYR A 1 123 ? -16.836 -45.364 22.394  1.00 16.97 ? 123 TYR A CD2 1 
ATOM   998  C CE1 . TYR A 1 123 ? -17.894 -47.903 22.103  1.00 18.13 ? 123 TYR A CE1 1 
ATOM   999  C CE2 . TYR A 1 123 ? -16.036 -46.491 22.656  1.00 16.71 ? 123 TYR A CE2 1 
ATOM   1000 C CZ  . TYR A 1 123 ? -16.578 -47.748 22.513  1.00 18.80 ? 123 TYR A CZ  1 
ATOM   1001 O OH  . TYR A 1 123 ? -15.828 -48.862 22.788  1.00 18.68 ? 123 TYR A OH  1 
ATOM   1002 N N   . ILE A 1 124 ? -18.180 -42.759 24.100  1.00 13.23 ? 124 ILE A N   1 
ATOM   1003 C CA  . ILE A 1 124 ? -17.427 -42.376 25.299  1.00 12.78 ? 124 ILE A CA  1 
ATOM   1004 C C   . ILE A 1 124 ? -17.112 -40.897 25.184  1.00 14.42 ? 124 ILE A C   1 
ATOM   1005 O O   . ILE A 1 124 ? -16.851 -40.395 24.081  1.00 13.08 ? 124 ILE A O   1 
ATOM   1006 C CB  . ILE A 1 124 ? -16.146 -43.214 25.475  1.00 11.52 ? 124 ILE A CB  1 
ATOM   1007 C CG1 . ILE A 1 124 ? -15.521 -43.016 26.866  1.00 13.75 ? 124 ILE A CG1 1 
ATOM   1008 C CG2 . ILE A 1 124 ? -15.091 -42.918 24.395  1.00 12.90 ? 124 ILE A CG2 1 
ATOM   1009 C CD1 . ILE A 1 124 ? -14.686 -44.213 27.332  1.00 15.04 ? 124 ILE A CD1 1 
ATOM   1010 N N   . ALA A 1 125 ? -17.147 -40.195 26.316  1.00 11.90 ? 125 ALA A N   1 
ATOM   1011 C CA  . ALA A 1 125 ? -16.858 -38.767 26.336  1.00 14.08 ? 125 ALA A CA  1 
ATOM   1012 C C   . ALA A 1 125 ? -15.985 -38.417 27.535  1.00 16.20 ? 125 ALA A C   1 
ATOM   1013 O O   . ALA A 1 125 ? -16.132 -38.998 28.613  1.00 14.46 ? 125 ALA A O   1 
ATOM   1014 C CB  . ALA A 1 125 ? -18.139 -37.928 26.386  1.00 12.75 ? 125 ALA A CB  1 
ATOM   1015 N N   . LEU A 1 126 ? -15.098 -37.446 27.347  1.00 15.95 ? 126 LEU A N   1 
ATOM   1016 C CA  . LEU A 1 126 ? -14.263 -36.956 28.441  1.00 13.94 ? 126 LEU A CA  1 
ATOM   1017 C C   . LEU A 1 126 ? -15.076 -35.987 29.291  1.00 15.97 ? 126 LEU A C   1 
ATOM   1018 O O   . LEU A 1 126 ? -15.672 -35.042 28.771  1.00 18.33 ? 126 LEU A O   1 
ATOM   1019 C CB  . LEU A 1 126 ? -12.996 -36.302 27.895  1.00 12.09 ? 126 LEU A CB  1 
ATOM   1020 C CG  . LEU A 1 126 ? -12.094 -35.678 28.966  1.00 15.47 ? 126 LEU A CG  1 
ATOM   1021 C CD1 . LEU A 1 126 ? -11.370 -36.792 29.656  1.00 13.95 ? 126 LEU A CD1 1 
ATOM   1022 C CD2 . LEU A 1 126 ? -11.040 -34.799 28.302  1.00 18.42 ? 126 LEU A CD2 1 
ATOM   1023 N N   . LYS A 1 127 ? -15.153 -36.253 30.589  1.00 14.31 ? 127 LYS A N   1 
ATOM   1024 C CA  . LYS A 1 127 ? -15.918 -35.373 31.449  1.00 19.22 ? 127 LYS A CA  1 
ATOM   1025 C C   . LYS A 1 127 ? -15.176 -34.059 31.674  1.00 23.24 ? 127 LYS A C   1 
ATOM   1026 O O   . LYS A 1 127 ? -13.982 -33.910 31.376  1.00 20.40 ? 127 LYS A O   1 
ATOM   1027 C CB  . LYS A 1 127 ? -16.195 -36.038 32.789  1.00 21.87 ? 127 LYS A CB  1 
ATOM   1028 C CG  . LYS A 1 127 ? -16.910 -37.359 32.701  1.00 20.28 ? 127 LYS A CG  1 
ATOM   1029 C CD  . LYS A 1 127 ? -17.791 -37.533 33.933  1.00 26.94 ? 127 LYS A CD  1 
ATOM   1030 C CE  . LYS A 1 127 ? -17.822 -38.990 34.352  1.00 28.58 ? 127 LYS A CE  1 
ATOM   1031 N NZ  . LYS A 1 127 ? -18.504 -39.187 35.662  1.00 32.10 ? 127 LYS A NZ  1 
ATOM   1032 N N   . GLU A 1 128 ? -15.910 -33.112 32.255  1.00 19.61 ? 128 GLU A N   1 
ATOM   1033 C CA  . GLU A 1 128 ? -15.426 -31.749 32.417  1.00 25.16 ? 128 GLU A CA  1 
ATOM   1034 C C   . GLU A 1 128 ? -14.192 -31.673 33.318  1.00 25.43 ? 128 GLU A C   1 
ATOM   1035 O O   . GLU A 1 128 ? -13.346 -30.794 33.131  1.00 25.77 ? 128 GLU A O   1 
ATOM   1036 C CB  . GLU A 1 128 ? -16.590 -30.902 32.937  1.00 28.55 ? 128 GLU A CB  1 
ATOM   1037 C CG  . GLU A 1 128 ? -16.271 -29.488 33.357  1.00 34.14 ? 128 GLU A CG  1 
ATOM   1038 C CD  . GLU A 1 128 ? -17.487 -28.576 33.253  1.00 45.66 ? 128 GLU A CD  1 
ATOM   1039 O OE1 . GLU A 1 128 ? -17.303 -27.368 32.985  1.00 45.30 ? 128 GLU A OE1 1 
ATOM   1040 O OE2 . GLU A 1 128 ? -18.630 -29.083 33.371  1.00 39.93 ? 128 GLU A OE2 1 
ATOM   1041 N N   . ASP A 1 129 ? -14.043 -32.597 34.264  1.00 17.77 ? 129 ASP A N   1 
ATOM   1042 C CA  . ASP A 1 129 ? -12.843 -32.623 35.096  1.00 25.31 ? 129 ASP A CA  1 
ATOM   1043 C C   . ASP A 1 129 ? -11.578 -33.042 34.334  1.00 25.57 ? 129 ASP A C   1 
ATOM   1044 O O   . ASP A 1 129 ? -10.483 -32.984 34.905  1.00 26.37 ? 129 ASP A O   1 
ATOM   1045 C CB  . ASP A 1 129 ? -13.127 -33.513 36.316  1.00 23.57 ? 129 ASP A CB  1 
ATOM   1046 C CG  . ASP A 1 129 ? -13.072 -35.014 36.011  1.00 30.32 ? 129 ASP A CG  1 
ATOM   1047 O OD1 . ASP A 1 129 ? -12.972 -35.432 34.834  1.00 29.45 ? 129 ASP A OD1 1 
ATOM   1048 O OD2 . ASP A 1 129 ? -13.215 -35.799 36.972  1.00 32.63 ? 129 ASP A OD2 1 
ATOM   1049 N N   . LEU A 1 130 ? -11.705 -33.423 33.059  1.00 24.59 ? 130 LEU A N   1 
ATOM   1050 C CA  . LEU A 1 130 ? -10.600 -33.885 32.215  1.00 23.09 ? 130 LEU A CA  1 
ATOM   1051 C C   . LEU A 1 130 ? -9.798  -35.004 32.864  1.00 22.66 ? 130 LEU A C   1 
ATOM   1052 O O   . LEU A 1 130 ? -8.651  -35.236 32.487  1.00 20.19 ? 130 LEU A O   1 
ATOM   1053 C CB  . LEU A 1 130 ? -9.669  -32.735 31.809  1.00 24.84 ? 130 LEU A CB  1 
ATOM   1054 C CG  . LEU A 1 130 ? -10.328 -31.439 31.330  1.00 26.33 ? 130 LEU A CG  1 
ATOM   1055 C CD1 . LEU A 1 130 ? -9.274  -30.409 30.941  1.00 26.42 ? 130 LEU A CD1 1 
ATOM   1056 C CD2 . LEU A 1 130 ? -11.256 -31.718 30.152  1.00 21.86 ? 130 LEU A CD2 1 
ATOM   1057 N N   . ARG A 1 131 ? -10.395 -35.727 33.813  1.00 17.51 ? 131 ARG A N   1 
ATOM   1058 C CA  . ARG A 1 131 ? -9.747  -36.852 34.470  1.00 22.25 ? 131 ARG A CA  1 
ATOM   1059 C C   . ARG A 1 131 ? -10.483 -38.172 34.288  1.00 22.99 ? 131 ARG A C   1 
ATOM   1060 O O   . ARG A 1 131 ? -9.892  -39.225 34.536  1.00 21.87 ? 131 ARG A O   1 
ATOM   1061 C CB  . ARG A 1 131 ? -9.626  -36.604 35.987  1.00 27.34 ? 131 ARG A CB  1 
ATOM   1062 C CG  . ARG A 1 131 ? -8.499  -35.683 36.429  1.00 37.73 ? 131 ARG A CG  1 
ATOM   1063 C CD  . ARG A 1 131 ? -9.007  -34.754 37.556  1.00 43.48 ? 131 ARG A CD  1 
ATOM   1064 N NE  . ARG A 1 131 ? -8.109  -33.645 37.874  1.00 45.55 ? 131 ARG A NE  1 
ATOM   1065 C CZ  . ARG A 1 131 ? -8.387  -32.365 37.644  1.00 43.53 ? 131 ARG A CZ  1 
ATOM   1066 N NH1 . ARG A 1 131 ? -9.544  -31.989 37.113  1.00 32.83 ? 131 ARG A NH1 1 
ATOM   1067 N NH2 . ARG A 1 131 ? -7.490  -31.437 37.968  1.00 43.66 ? 131 ARG A NH2 1 
ATOM   1068 N N   . SER A 1 132 ? -11.755 -38.153 33.892  1.00 20.30 ? 132 SER A N   1 
ATOM   1069 C CA  . SER A 1 132 ? -12.579 -39.352 33.890  1.00 19.23 ? 132 SER A CA  1 
ATOM   1070 C C   . SER A 1 132 ? -13.447 -39.349 32.640  1.00 17.26 ? 132 SER A C   1 
ATOM   1071 O O   . SER A 1 132 ? -13.583 -38.332 31.961  1.00 15.48 ? 132 SER A O   1 
ATOM   1072 C CB  . SER A 1 132 ? -13.470 -39.429 35.135  1.00 21.36 ? 132 SER A CB  1 
ATOM   1073 O OG  . SER A 1 132 ? -14.086 -38.178 35.364  1.00 26.19 ? 132 SER A OG  1 
ATOM   1074 N N   . TRP A 1 133 ? -14.071 -40.487 32.375  1.00 17.46 ? 133 TRP A N   1 
ATOM   1075 C CA  . TRP A 1 133 ? -14.845 -40.698 31.163  1.00 16.43 ? 133 TRP A CA  1 
ATOM   1076 C C   . TRP A 1 133 ? -16.285 -41.042 31.508  1.00 19.15 ? 133 TRP A C   1 
ATOM   1077 O O   . TRP A 1 133 ? -16.561 -41.628 32.559  1.00 17.41 ? 133 TRP A O   1 
ATOM   1078 C CB  . TRP A 1 133 ? -14.236 -41.827 30.350  1.00 15.04 ? 133 TRP A CB  1 
ATOM   1079 C CG  . TRP A 1 133 ? -12.805 -41.547 30.013  1.00 17.38 ? 133 TRP A CG  1 
ATOM   1080 C CD1 . TRP A 1 133 ? -11.693 -41.889 30.743  1.00 16.24 ? 133 TRP A CD1 1 
ATOM   1081 C CD2 . TRP A 1 133 ? -12.336 -40.857 28.862  1.00 15.69 ? 133 TRP A CD2 1 
ATOM   1082 N NE1 . TRP A 1 133 ? -10.552 -41.458 30.092  1.00 15.84 ? 133 TRP A NE1 1 
ATOM   1083 C CE2 . TRP A 1 133 ? -10.924 -40.815 28.941  1.00 14.12 ? 133 TRP A CE2 1 
ATOM   1084 C CE3 . TRP A 1 133 ? -12.967 -40.277 27.761  1.00 14.42 ? 133 TRP A CE3 1 
ATOM   1085 C CZ2 . TRP A 1 133 ? -10.151 -40.215 27.971  1.00 11.59 ? 133 TRP A CZ2 1 
ATOM   1086 C CZ3 . TRP A 1 133 ? -12.181 -39.671 26.792  1.00 13.61 ? 133 TRP A CZ3 1 
ATOM   1087 C CH2 . TRP A 1 133 ? -10.793 -39.647 26.907  1.00 14.83 ? 133 TRP A CH2 1 
ATOM   1088 N N   . THR A 1 134 ? -17.197 -40.691 30.604  1.00 16.17 ? 134 THR A N   1 
ATOM   1089 C CA  . THR A 1 134 ? -18.572 -41.176 30.655  1.00 17.85 ? 134 THR A CA  1 
ATOM   1090 C C   . THR A 1 134 ? -18.818 -42.087 29.461  1.00 20.48 ? 134 THR A C   1 
ATOM   1091 O O   . THR A 1 134 ? -18.683 -41.665 28.302  1.00 15.13 ? 134 THR A O   1 
ATOM   1092 C CB  . THR A 1 134 ? -19.592 -40.038 30.721  1.00 14.98 ? 134 THR A CB  1 
ATOM   1093 O OG1 . THR A 1 134 ? -20.902 -40.606 30.781  1.00 20.68 ? 134 THR A OG1 1 
ATOM   1094 C CG2 . THR A 1 134 ? -19.490 -39.075 29.553  1.00 16.33 ? 134 THR A CG2 1 
ATOM   1095 N N   . ALA A 1 135 ? -19.112 -43.351 29.762  1.00 19.24 ? 135 ALA A N   1 
ATOM   1096 C CA  . ALA A 1 135 ? -19.309 -44.403 28.780  1.00 17.92 ? 135 ALA A CA  1 
ATOM   1097 C C   . ALA A 1 135 ? -20.798 -44.686 28.654  1.00 20.47 ? 135 ALA A C   1 
ATOM   1098 O O   . ALA A 1 135 ? -21.516 -44.722 29.658  1.00 17.89 ? 135 ALA A O   1 
ATOM   1099 C CB  . ALA A 1 135 ? -18.570 -45.677 29.188  1.00 14.24 ? 135 ALA A CB  1 
ATOM   1100 N N   . ALA A 1 136 ? -21.256 -44.907 27.429  1.00 16.76 ? 136 ALA A N   1 
ATOM   1101 C CA  . ALA A 1 136 ? -22.695 -44.976 27.211  1.00 21.68 ? 136 ALA A CA  1 
ATOM   1102 C C   . ALA A 1 136 ? -23.298 -46.354 27.456  1.00 20.59 ? 136 ALA A C   1 
ATOM   1103 O O   . ALA A 1 136 ? -24.471 -46.438 27.833  1.00 24.87 ? 136 ALA A O   1 
ATOM   1104 C CB  . ALA A 1 136 ? -23.035 -44.528 25.791  1.00 20.56 ? 136 ALA A CB  1 
ATOM   1105 N N   . ASP A 1 137 ? -22.563 -47.435 27.222  1.00 20.74 ? 137 ASP A N   1 
ATOM   1106 C CA  . ASP A 1 137 ? -23.121 -48.777 27.365  1.00 22.83 ? 137 ASP A CA  1 
ATOM   1107 C C   . ASP A 1 137 ? -21.998 -49.700 27.812  1.00 22.40 ? 137 ASP A C   1 
ATOM   1108 O O   . ASP A 1 137 ? -20.895 -49.243 28.129  1.00 21.78 ? 137 ASP A O   1 
ATOM   1109 C CB  . ASP A 1 137 ? -23.745 -49.253 26.048  1.00 20.90 ? 137 ASP A CB  1 
ATOM   1110 C CG  . ASP A 1 137 ? -22.826 -49.025 24.867  1.00 24.82 ? 137 ASP A CG  1 
ATOM   1111 O OD1 . ASP A 1 137 ? -21.606 -49.228 25.036  1.00 25.85 ? 137 ASP A OD1 1 
ATOM   1112 O OD2 . ASP A 1 137 ? -23.300 -48.632 23.779  1.00 26.06 ? 137 ASP A OD2 1 
ATOM   1113 N N   . MET A 1 138 ? -22.253 -51.014 27.785  1.00 20.03 ? 138 MET A N   1 
ATOM   1114 C CA  . MET A 1 138 ? -21.232 -51.954 28.241  1.00 22.53 ? 138 MET A CA  1 
ATOM   1115 C C   . MET A 1 138 ? -20.064 -52.055 27.280  1.00 23.30 ? 138 MET A C   1 
ATOM   1116 O O   . MET A 1 138 ? -18.941 -52.332 27.715  1.00 22.65 ? 138 MET A O   1 
ATOM   1117 C CB  . MET A 1 138 ? -21.805 -53.347 28.460  1.00 28.59 ? 138 MET A CB  1 
ATOM   1118 C CG  . MET A 1 138 ? -22.672 -53.461 29.688  1.00 38.44 ? 138 MET A CG  1 
ATOM   1119 S SD  . MET A 1 138 ? -23.342 -55.127 29.794  1.00 62.31 ? 138 MET A SD  1 
ATOM   1120 C CE  . MET A 1 138 ? -21.905 -56.057 30.331  1.00 41.81 ? 138 MET A CE  1 
ATOM   1121 N N   . ALA A 1 139 ? -20.300 -51.870 25.982  1.00 19.53 ? 139 ALA A N   1 
ATOM   1122 C CA  . ALA A 1 139 ? -19.186 -51.872 25.041  1.00 22.70 ? 139 ALA A CA  1 
ATOM   1123 C C   . ALA A 1 139 ? -18.220 -50.735 25.346  1.00 18.69 ? 139 ALA A C   1 
ATOM   1124 O O   . ALA A 1 139 ? -17.010 -50.949 25.496  1.00 22.83 ? 139 ALA A O   1 
ATOM   1125 C CB  . ALA A 1 139 ? -19.711 -51.771 23.612  1.00 22.47 ? 139 ALA A CB  1 
ATOM   1126 N N   . ALA A 1 140 ? -18.743 -49.515 25.471  1.00 18.46 ? 140 ALA A N   1 
ATOM   1127 C CA  . ALA A 1 140 ? -17.881 -48.384 25.785  1.00 18.87 ? 140 ALA A CA  1 
ATOM   1128 C C   . ALA A 1 140 ? -17.239 -48.494 27.168  1.00 20.39 ? 140 ALA A C   1 
ATOM   1129 O O   . ALA A 1 140 ? -16.215 -47.850 27.403  1.00 17.86 ? 140 ALA A O   1 
ATOM   1130 C CB  . ALA A 1 140 ? -18.662 -47.081 25.688  1.00 18.94 ? 140 ALA A CB  1 
ATOM   1131 N N   . GLN A 1 141 ? -17.823 -49.259 28.101  1.00 16.90 ? 141 GLN A N   1 
ATOM   1132 C CA  . GLN A 1 141 ? -17.158 -49.428 29.388  1.00 21.95 ? 141 GLN A CA  1 
ATOM   1133 C C   . GLN A 1 141 ? -15.862 -50.218 29.244  1.00 18.91 ? 141 GLN A C   1 
ATOM   1134 O O   . GLN A 1 141 ? -14.967 -50.074 30.077  1.00 20.59 ? 141 GLN A O   1 
ATOM   1135 C CB  . GLN A 1 141 ? -18.072 -50.113 30.411  1.00 21.62 ? 141 GLN A CB  1 
ATOM   1136 C CG  . GLN A 1 141 ? -19.361 -49.366 30.747  1.00 25.49 ? 141 GLN A CG  1 
ATOM   1137 C CD  . GLN A 1 141 ? -20.327 -50.231 31.550  1.00 32.73 ? 141 GLN A CD  1 
ATOM   1138 O OE1 . GLN A 1 141 ? -19.931 -51.237 32.137  1.00 38.49 ? 141 GLN A OE1 1 
ATOM   1139 N NE2 . GLN A 1 141 ? -21.603 -49.867 31.540  1.00 32.40 ? 141 GLN A NE2 1 
ATOM   1140 N N   . ILE A 1 142 ? -15.752 -51.069 28.221  1.00 20.53 ? 142 ILE A N   1 
ATOM   1141 C CA  . ILE A 1 142 ? -14.479 -51.732 27.933  1.00 20.97 ? 142 ILE A CA  1 
ATOM   1142 C C   . ILE A 1 142 ? -13.397 -50.702 27.645  1.00 20.55 ? 142 ILE A C   1 
ATOM   1143 O O   . ILE A 1 142 ? -12.307 -50.745 28.226  1.00 18.06 ? 142 ILE A O   1 
ATOM   1144 C CB  . ILE A 1 142 ? -14.631 -52.721 26.763  1.00 21.31 ? 142 ILE A CB  1 
ATOM   1145 C CG1 . ILE A 1 142 ? -15.816 -53.672 27.006  1.00 25.43 ? 142 ILE A CG1 1 
ATOM   1146 C CG2 . ILE A 1 142 ? -13.298 -53.421 26.449  1.00 15.81 ? 142 ILE A CG2 1 
ATOM   1147 C CD1 . ILE A 1 142 ? -15.888 -54.875 26.062  1.00 22.71 ? 142 ILE A CD1 1 
ATOM   1148 N N   . THR A 1 143 ? -13.684 -49.771 26.731  1.00 17.80 ? 143 THR A N   1 
ATOM   1149 C CA  . THR A 1 143 ? -12.735 -48.704 26.416  1.00 19.20 ? 143 THR A CA  1 
ATOM   1150 C C   . THR A 1 143 ? -12.470 -47.827 27.629  1.00 19.94 ? 143 THR A C   1 
ATOM   1151 O O   . THR A 1 143 ? -11.335 -47.400 27.855  1.00 17.91 ? 143 THR A O   1 
ATOM   1152 C CB  . THR A 1 143 ? -13.260 -47.839 25.268  1.00 19.67 ? 143 THR A CB  1 
ATOM   1153 O OG1 . THR A 1 143 ? -13.569 -48.655 24.130  1.00 20.24 ? 143 THR A OG1 1 
ATOM   1154 C CG2 . THR A 1 143 ? -12.250 -46.766 24.893  1.00 19.48 ? 143 THR A CG2 1 
ATOM   1155 N N   . LYS A 1 144 ? -13.518 -47.520 28.399  1.00 19.43 ? 144 LYS A N   1 
ATOM   1156 C CA  . LYS A 1 144 ? -13.349 -46.690 29.584  1.00 19.32 ? 144 LYS A CA  1 
ATOM   1157 C C   . LYS A 1 144 ? -12.327 -47.293 30.541  1.00 20.44 ? 144 LYS A C   1 
ATOM   1158 O O   . LYS A 1 144 ? -11.416 -46.599 31.014  1.00 18.43 ? 144 LYS A O   1 
ATOM   1159 C CB  . LYS A 1 144 ? -14.690 -46.511 30.281  1.00 17.24 ? 144 LYS A CB  1 
ATOM   1160 C CG  . LYS A 1 144 ? -14.622 -45.604 31.472  1.00 19.33 ? 144 LYS A CG  1 
ATOM   1161 C CD  . LYS A 1 144 ? -16.018 -45.299 31.981  1.00 22.86 ? 144 LYS A CD  1 
ATOM   1162 C CE  . LYS A 1 144 ? -16.196 -45.754 33.405  1.00 29.32 ? 144 LYS A CE  1 
ATOM   1163 N NZ  . LYS A 1 144 ? -16.226 -44.563 34.274  1.00 34.02 ? 144 LYS A NZ  1 
ATOM   1164 N N   . ARG A 1 145 ? -12.463 -48.588 30.846  1.00 21.14 ? 145 ARG A N   1 
ATOM   1165 C CA  . ARG A 1 145 ? -11.510 -49.208 31.763  1.00 21.98 ? 145 ARG A CA  1 
ATOM   1166 C C   . ARG A 1 145 ? -10.105 -49.178 31.183  1.00 22.22 ? 145 ARG A C   1 
ATOM   1167 O O   . ARG A 1 145 ? -9.136  -48.891 31.896  1.00 23.54 ? 145 ARG A O   1 
ATOM   1168 C CB  . ARG A 1 145 ? -11.913 -50.646 32.097  1.00 24.17 ? 145 ARG A CB  1 
ATOM   1169 C CG  . ARG A 1 145 ? -13.063 -50.764 33.099  1.00 33.07 ? 145 ARG A CG  1 
ATOM   1170 C CD  . ARG A 1 145 ? -13.305 -52.227 33.514  1.00 33.91 ? 145 ARG A CD  1 
ATOM   1171 N NE  . ARG A 1 145 ? -13.862 -53.034 32.431  1.00 38.20 ? 145 ARG A NE  1 
ATOM   1172 C CZ  . ARG A 1 145 ? -15.141 -53.052 32.067  1.00 38.32 ? 145 ARG A CZ  1 
ATOM   1173 N NH1 . ARG A 1 145 ? -16.061 -52.349 32.715  1.00 41.08 ? 145 ARG A NH1 1 
ATOM   1174 N NH2 . ARG A 1 145 ? -15.506 -53.792 31.021  1.00 31.83 ? 145 ARG A NH2 1 
ATOM   1175 N N   . LYS A 1 146 ? -9.973  -49.437 29.883  1.00 18.96 ? 146 LYS A N   1 
ATOM   1176 C CA  . LYS A 1 146 ? -8.643  -49.449 29.291  1.00 18.93 ? 146 LYS A CA  1 
ATOM   1177 C C   . LYS A 1 146 ? -8.034  -48.049 29.297  1.00 20.34 ? 146 LYS A C   1 
ATOM   1178 O O   . LYS A 1 146 ? -6.847  -47.879 29.610  1.00 20.77 ? 146 LYS A O   1 
ATOM   1179 C CB  . LYS A 1 146 ? -8.714  -50.029 27.878  1.00 22.01 ? 146 LYS A CB  1 
ATOM   1180 C CG  . LYS A 1 146 ? -7.510  -49.732 27.019  1.00 29.40 ? 146 LYS A CG  1 
ATOM   1181 C CD  . LYS A 1 146 ? -7.556  -50.446 25.658  1.00 31.03 ? 146 LYS A CD  1 
ATOM   1182 C CE  . LYS A 1 146 ? -6.921  -49.577 24.575  1.00 29.61 ? 146 LYS A CE  1 
ATOM   1183 N NZ  . LYS A 1 146 ? -6.781  -50.285 23.271  1.00 35.34 ? 146 LYS A NZ  1 
ATOM   1184 N N   . TRP A 1 147 ? -8.838  -47.028 28.999  1.00 15.69 ? 147 TRP A N   1 
ATOM   1185 C CA  . TRP A 1 147 ? -8.329  -45.661 28.963  1.00 16.80 ? 147 TRP A CA  1 
ATOM   1186 C C   . TRP A 1 147 ? -8.042  -45.109 30.360  1.00 19.02 ? 147 TRP A C   1 
ATOM   1187 O O   . TRP A 1 147 ? -7.152  -44.264 30.510  1.00 17.04 ? 147 TRP A O   1 
ATOM   1188 C CB  . TRP A 1 147 ? -9.322  -44.761 28.215  1.00 16.38 ? 147 TRP A CB  1 
ATOM   1189 C CG  . TRP A 1 147 ? -9.282  -44.962 26.718  1.00 16.16 ? 147 TRP A CG  1 
ATOM   1190 C CD1 . TRP A 1 147 ? -8.561  -45.907 26.028  1.00 15.84 ? 147 TRP A CD1 1 
ATOM   1191 C CD2 . TRP A 1 147 ? -9.978  -44.192 25.730  1.00 16.34 ? 147 TRP A CD2 1 
ATOM   1192 N NE1 . TRP A 1 147 ? -8.771  -45.768 24.675  1.00 16.79 ? 147 TRP A NE1 1 
ATOM   1193 C CE2 . TRP A 1 147 ? -9.634  -44.723 24.466  1.00 18.48 ? 147 TRP A CE2 1 
ATOM   1194 C CE3 . TRP A 1 147 ? -10.853 -43.104 25.790  1.00 15.20 ? 147 TRP A CE3 1 
ATOM   1195 C CZ2 . TRP A 1 147 ? -10.144 -44.206 23.278  1.00 17.28 ? 147 TRP A CZ2 1 
ATOM   1196 C CZ3 . TRP A 1 147 ? -11.363 -42.594 24.605  1.00 14.64 ? 147 TRP A CZ3 1 
ATOM   1197 C CH2 . TRP A 1 147 ? -11.006 -43.144 23.372  1.00 22.86 ? 147 TRP A CH2 1 
ATOM   1198 N N   . GLU A 1 148 ? -8.789  -45.538 31.384  1.00 18.74 ? 148 GLU A N   1 
ATOM   1199 C CA  . GLU A 1 148 ? -8.452  -45.147 32.755  1.00 18.96 ? 148 GLU A CA  1 
ATOM   1200 C C   . GLU A 1 148 ? -7.108  -45.736 33.179  1.00 22.86 ? 148 GLU A C   1 
ATOM   1201 O O   . GLU A 1 148 ? -6.250  -45.039 33.744  1.00 20.98 ? 148 GLU A O   1 
ATOM   1202 C CB  . GLU A 1 148 ? -9.551  -45.581 33.737  1.00 20.31 ? 148 GLU A CB  1 
ATOM   1203 C CG  . GLU A 1 148 ? -10.850 -44.797 33.657  1.00 18.77 ? 148 GLU A CG  1 
ATOM   1204 C CD  . GLU A 1 148 ? -11.996 -45.471 34.411  1.00 27.79 ? 148 GLU A CD  1 
ATOM   1205 O OE1 . GLU A 1 148 ? -11.914 -46.690 34.681  1.00 31.88 ? 148 GLU A OE1 1 
ATOM   1206 O OE2 . GLU A 1 148 ? -12.971 -44.775 34.756  1.00 27.95 ? 148 GLU A OE2 1 
ATOM   1207 N N   . ALA A 1 149 ? -6.914  -47.031 32.924  1.00 21.30 ? 149 ALA A N   1 
ATOM   1208 C CA  . ALA A 1 149 ? -5.652  -47.673 33.261  1.00 23.39 ? 149 ALA A CA  1 
ATOM   1209 C C   . ALA A 1 149 ? -4.485  -47.005 32.554  1.00 22.89 ? 149 ALA A C   1 
ATOM   1210 O O   . ALA A 1 149 ? -3.389  -46.906 33.117  1.00 20.64 ? 149 ALA A O   1 
ATOM   1211 C CB  . ALA A 1 149 ? -5.715  -49.160 32.907  1.00 24.52 ? 149 ALA A CB  1 
ATOM   1212 N N   . ALA A 1 150 ? -4.694  -46.519 31.338  1.00 20.15 ? 150 ALA A N   1 
ATOM   1213 C CA  . ALA A 1 150 ? -3.587  -45.963 30.572  1.00 21.40 ? 150 ALA A CA  1 
ATOM   1214 C C   . ALA A 1 150 ? -3.454  -44.458 30.734  1.00 15.19 ? 150 ALA A C   1 
ATOM   1215 O O   . ALA A 1 150 ? -2.562  -43.862 30.112  1.00 19.08 ? 150 ALA A O   1 
ATOM   1216 C CB  . ALA A 1 150 ? -3.734  -46.318 29.091  1.00 20.50 ? 150 ALA A CB  1 
ATOM   1217 N N   . HIS A 1 151 ? -4.319  -43.841 31.537  1.00 15.93 ? 151 HIS A N   1 
ATOM   1218 C CA  . HIS A 1 151 ? -4.286  -42.401 31.802  1.00 16.60 ? 151 HIS A CA  1 
ATOM   1219 C C   . HIS A 1 151 ? -4.388  -41.597 30.511  1.00 17.80 ? 151 HIS A C   1 
ATOM   1220 O O   . HIS A 1 151 ? -3.680  -40.608 30.312  1.00 14.87 ? 151 HIS A O   1 
ATOM   1221 C CB  . HIS A 1 151 ? -3.043  -42.026 32.610  1.00 15.99 ? 151 HIS A CB  1 
ATOM   1222 C CG  . HIS A 1 151 ? -2.948  -42.785 33.896  1.00 19.23 ? 151 HIS A CG  1 
ATOM   1223 N ND1 . HIS A 1 151 ? -3.664  -42.436 35.023  1.00 23.13 ? 151 HIS A ND1 1 
ATOM   1224 C CD2 . HIS A 1 151 ? -2.321  -43.944 34.194  1.00 15.23 ? 151 HIS A CD2 1 
ATOM   1225 C CE1 . HIS A 1 151 ? -3.428  -43.312 35.982  1.00 18.31 ? 151 HIS A CE1 1 
ATOM   1226 N NE2 . HIS A 1 151 ? -2.617  -44.238 35.504  1.00 23.11 ? 151 HIS A NE2 1 
ATOM   1227 N N   . VAL A 1 152 ? -5.304  -42.019 29.635  1.00 15.39 ? 152 VAL A N   1 
ATOM   1228 C CA  . VAL A 1 152 ? -5.507  -41.321 28.369  1.00 13.16 ? 152 VAL A CA  1 
ATOM   1229 C C   . VAL A 1 152 ? -5.944  -39.883 28.610  1.00 13.08 ? 152 VAL A C   1 
ATOM   1230 O O   . VAL A 1 152 ? -5.467  -38.958 27.942  1.00 12.89 ? 152 VAL A O   1 
ATOM   1231 C CB  . VAL A 1 152 ? -6.521  -42.088 27.506  1.00 13.86 ? 152 VAL A CB  1 
ATOM   1232 C CG1 . VAL A 1 152 ? -6.925  -41.241 26.305  1.00 14.25 ? 152 VAL A CG1 1 
ATOM   1233 C CG2 . VAL A 1 152 ? -5.933  -43.425 27.065  1.00 18.25 ? 152 VAL A CG2 1 
ATOM   1234 N N   . ALA A 1 153 ? -6.831  -39.664 29.588  1.00 10.77 ? 153 ALA A N   1 
ATOM   1235 C CA  . ALA A 1 153 ? -7.379  -38.329 29.817  1.00 12.77 ? 153 ALA A CA  1 
ATOM   1236 C C   . ALA A 1 153 ? -6.289  -37.337 30.191  1.00 15.79 ? 153 ALA A C   1 
ATOM   1237 O O   . ALA A 1 153 ? -6.217  -36.230 29.640  1.00 14.23 ? 153 ALA A O   1 
ATOM   1238 C CB  . ALA A 1 153 ? -8.445  -38.384 30.917  1.00 12.98 ? 153 ALA A CB  1 
ATOM   1239 N N   . GLU A 1 154 ? -5.440  -37.715 31.151  1.00 13.76 ? 154 GLU A N   1 
ATOM   1240 C CA  . GLU A 1 154 ? -4.330  -36.867 31.556  1.00 14.30 ? 154 GLU A CA  1 
ATOM   1241 C C   . GLU A 1 154 ? -3.454  -36.484 30.365  1.00 16.54 ? 154 GLU A C   1 
ATOM   1242 O O   . GLU A 1 154 ? -2.971  -35.349 30.269  1.00 16.15 ? 154 GLU A O   1 
ATOM   1243 C CB  . GLU A 1 154 ? -3.481  -37.603 32.595  1.00 12.67 ? 154 GLU A CB  1 
ATOM   1244 C CG  . GLU A 1 154 ? -4.015  -37.709 34.017  1.00 19.25 ? 154 GLU A CG  1 
ATOM   1245 C CD  . GLU A 1 154 ? -5.177  -38.665 34.210  1.00 24.07 ? 154 GLU A CD  1 
ATOM   1246 O OE1 . GLU A 1 154 ? -5.455  -39.523 33.326  1.00 21.58 ? 154 GLU A OE1 1 
ATOM   1247 O OE2 . GLU A 1 154 ? -5.758  -38.612 35.317  1.00 26.66 ? 154 GLU A OE2 1 
ATOM   1248 N N   . GLN A 1 155 ? -3.192  -37.434 29.476  1.00 13.63 ? 155 GLN A N   1 
ATOM   1249 C CA  . GLN A 1 155 ? -2.310  -37.134 28.362  1.00 15.76 ? 155 GLN A CA  1 
ATOM   1250 C C   . GLN A 1 155 ? -2.969  -36.259 27.297  1.00 20.03 ? 155 GLN A C   1 
ATOM   1251 O O   . GLN A 1 155 ? -2.268  -35.797 26.390  1.00 20.24 ? 155 GLN A O   1 
ATOM   1252 C CB  . GLN A 1 155 ? -1.767  -38.426 27.757  1.00 18.68 ? 155 GLN A CB  1 
ATOM   1253 C CG  . GLN A 1 155 ? -1.116  -39.354 28.795  1.00 20.21 ? 155 GLN A CG  1 
ATOM   1254 C CD  . GLN A 1 155 ? -0.803  -40.741 28.250  1.00 26.66 ? 155 GLN A CD  1 
ATOM   1255 O OE1 . GLN A 1 155 ? -0.986  -41.747 28.933  1.00 28.78 ? 155 GLN A OE1 1 
ATOM   1256 N NE2 . GLN A 1 155 ? -0.246  -40.788 27.049  1.00 32.43 ? 155 GLN A NE2 1 
ATOM   1257 N N   . GLN A 1 156 ? -4.273  -35.987 27.402  1.00 12.71 ? 156 GLN A N   1 
ATOM   1258 C CA  . GLN A 1 156 ? -4.931  -35.017 26.534  1.00 13.92 ? 156 GLN A CA  1 
ATOM   1259 C C   . GLN A 1 156 ? -4.898  -33.601 27.087  1.00 14.64 ? 156 GLN A C   1 
ATOM   1260 O O   . GLN A 1 156 ? -5.308  -32.670 26.386  1.00 14.08 ? 156 GLN A O   1 
ATOM   1261 C CB  . GLN A 1 156 ? -6.407  -35.397 26.299  1.00 16.52 ? 156 GLN A CB  1 
ATOM   1262 C CG  . GLN A 1 156 ? -6.646  -36.766 25.713  1.00 17.90 ? 156 GLN A CG  1 
ATOM   1263 C CD  . GLN A 1 156 ? -5.594  -37.149 24.712  1.00 18.59 ? 156 GLN A CD  1 
ATOM   1264 O OE1 . GLN A 1 156 ? -5.476  -36.533 23.647  1.00 20.37 ? 156 GLN A OE1 1 
ATOM   1265 N NE2 . GLN A 1 156 ? -4.815  -38.182 25.037  1.00 24.82 ? 156 GLN A NE2 1 
ATOM   1266 N N   . ARG A 1 157 ? -4.452  -33.399 28.328  1.00 15.37 ? 157 ARG A N   1 
ATOM   1267 C CA  . ARG A 1 157 ? -4.694  -32.094 28.928  1.00 15.05 ? 157 ARG A CA  1 
ATOM   1268 C C   . ARG A 1 157 ? -3.781  -31.027 28.353  1.00 15.43 ? 157 ARG A C   1 
ATOM   1269 O O   . ARG A 1 157 ? -4.187  -29.861 28.264  1.00 14.00 ? 157 ARG A O   1 
ATOM   1270 C CB  . ARG A 1 157 ? -4.580  -32.187 30.445  1.00 18.32 ? 157 ARG A CB  1 
ATOM   1271 C CG  . ARG A 1 157 ? -5.589  -33.217 30.941  1.00 22.77 ? 157 ARG A CG  1 
ATOM   1272 C CD  . ARG A 1 157 ? -5.768  -33.243 32.414  1.00 28.50 ? 157 ARG A CD  1 
ATOM   1273 N NE  . ARG A 1 157 ? -6.000  -31.907 32.933  1.00 32.09 ? 157 ARG A NE  1 
ATOM   1274 C CZ  . ARG A 1 157 ? -6.080  -31.636 34.224  1.00 35.33 ? 157 ARG A CZ  1 
ATOM   1275 N NH1 . ARG A 1 157 ? -6.022  -32.597 35.133  1.00 36.38 ? 157 ARG A NH1 1 
ATOM   1276 N NH2 . ARG A 1 157 ? -6.223  -30.372 34.612  1.00 34.99 ? 157 ARG A NH2 1 
ATOM   1277 N N   . ALA A 1 158 ? -2.560  -31.394 27.948  1.00 12.77 ? 158 ALA A N   1 
ATOM   1278 C CA  . ALA A 1 158 ? -1.693  -30.421 27.296  1.00 13.87 ? 158 ALA A CA  1 
ATOM   1279 C C   . ALA A 1 158 ? -2.352  -29.872 26.036  1.00 14.68 ? 158 ALA A C   1 
ATOM   1280 O O   . ALA A 1 158 ? -2.379  -28.657 25.813  1.00 14.03 ? 158 ALA A O   1 
ATOM   1281 C CB  . ALA A 1 158 ? -0.340  -31.048 26.963  1.00 13.97 ? 158 ALA A CB  1 
ATOM   1282 N N   . TYR A 1 159 ? -2.910  -30.746 25.202  1.00 12.62 ? 159 TYR A N   1 
ATOM   1283 C CA  . TYR A 1 159 ? -3.602  -30.237 24.021  1.00 13.32 ? 159 TYR A CA  1 
ATOM   1284 C C   . TYR A 1 159 ? -4.786  -29.357 24.420  1.00 13.52 ? 159 TYR A C   1 
ATOM   1285 O O   . TYR A 1 159 ? -4.923  -28.224 23.945  1.00 12.70 ? 159 TYR A O   1 
ATOM   1286 C CB  . TYR A 1 159 ? -4.072  -31.385 23.118  1.00 14.17 ? 159 TYR A CB  1 
ATOM   1287 C CG  . TYR A 1 159 ? -4.959  -30.848 22.034  1.00 15.15 ? 159 TYR A CG  1 
ATOM   1288 C CD1 . TYR A 1 159 ? -4.403  -30.277 20.897  1.00 15.89 ? 159 TYR A CD1 1 
ATOM   1289 C CD2 . TYR A 1 159 ? -6.350  -30.849 22.162  1.00 13.39 ? 159 TYR A CD2 1 
ATOM   1290 C CE1 . TYR A 1 159 ? -5.212  -29.734 19.896  1.00 14.96 ? 159 TYR A CE1 1 
ATOM   1291 C CE2 . TYR A 1 159 ? -7.159  -30.318 21.165  1.00 13.85 ? 159 TYR A CE2 1 
ATOM   1292 C CZ  . TYR A 1 159 ? -6.580  -29.757 20.040  1.00 14.76 ? 159 TYR A CZ  1 
ATOM   1293 O OH  . TYR A 1 159 ? -7.372  -29.215 19.059  1.00 15.79 ? 159 TYR A OH  1 
ATOM   1294 N N   . LEU A 1 160 ? -5.668  -29.873 25.281  1.00 13.20 ? 160 LEU A N   1 
ATOM   1295 C CA  . LEU A 1 160 ? -6.943  -29.199 25.510  1.00 12.38 ? 160 LEU A CA  1 
ATOM   1296 C C   . LEU A 1 160 ? -6.751  -27.847 26.177  1.00 17.01 ? 160 LEU A C   1 
ATOM   1297 O O   . LEU A 1 160 ? -7.413  -26.873 25.804  1.00 16.26 ? 160 LEU A O   1 
ATOM   1298 C CB  . LEU A 1 160 ? -7.859  -30.090 26.349  1.00 14.63 ? 160 LEU A CB  1 
ATOM   1299 C CG  . LEU A 1 160 ? -8.364  -31.324 25.607  1.00 12.52 ? 160 LEU A CG  1 
ATOM   1300 C CD1 . LEU A 1 160 ? -9.153  -32.205 26.557  1.00 16.89 ? 160 LEU A CD1 1 
ATOM   1301 C CD2 . LEU A 1 160 ? -9.222  -30.925 24.399  1.00 14.38 ? 160 LEU A CD2 1 
ATOM   1302 N N   . GLU A 1 161 ? -5.851  -27.763 27.162  1.00 14.99 ? 161 GLU A N   1 
ATOM   1303 C CA  . GLU A 1 161 ? -5.617  -26.510 27.874  1.00 18.28 ? 161 GLU A CA  1 
ATOM   1304 C C   . GLU A 1 161 ? -4.480  -25.683 27.283  1.00 18.58 ? 161 GLU A C   1 
ATOM   1305 O O   . GLU A 1 161 ? -4.346  -24.501 27.627  1.00 20.96 ? 161 GLU A O   1 
ATOM   1306 C CB  . GLU A 1 161 ? -5.337  -26.788 29.365  1.00 19.47 ? 161 GLU A CB  1 
ATOM   1307 C CG  . GLU A 1 161 ? -6.546  -27.406 30.099  1.00 19.73 ? 161 GLU A CG  1 
ATOM   1308 C CD  . GLU A 1 161 ? -6.237  -27.861 31.531  1.00 34.10 ? 161 GLU A CD  1 
ATOM   1309 O OE1 . GLU A 1 161 ? -6.278  -27.001 32.441  1.00 34.10 ? 161 GLU A OE1 1 
ATOM   1310 O OE2 . GLU A 1 161 ? -5.969  -29.065 31.753  1.00 32.37 ? 161 GLU A OE2 1 
ATOM   1311 N N   . GLY A 1 162 ? -3.668  -26.255 26.405  1.00 16.30 ? 162 GLY A N   1 
ATOM   1312 C CA  . GLY A 1 162 ? -2.545  -25.521 25.858  1.00 19.19 ? 162 GLY A CA  1 
ATOM   1313 C C   . GLY A 1 162 ? -2.679  -25.232 24.380  1.00 16.74 ? 162 GLY A C   1 
ATOM   1314 O O   . GLY A 1 162 ? -3.027  -24.112 24.005  1.00 15.73 ? 162 GLY A O   1 
ATOM   1315 N N   . THR A 1 163 ? -2.410  -26.237 23.544  1.00 14.32 ? 163 THR A N   1 
ATOM   1316 C CA  . THR A 1 163 ? -2.451  -26.060 22.092  1.00 18.85 ? 163 THR A CA  1 
ATOM   1317 C C   . THR A 1 163 ? -3.791  -25.506 21.622  1.00 17.18 ? 163 THR A C   1 
ATOM   1318 O O   . THR A 1 163 ? -3.852  -24.594 20.783  1.00 14.69 ? 163 THR A O   1 
ATOM   1319 C CB  . THR A 1 163 ? -2.194  -27.400 21.402  1.00 19.62 ? 163 THR A CB  1 
ATOM   1320 O OG1 . THR A 1 163 ? -1.029  -27.995 21.969  1.00 24.88 ? 163 THR A OG1 1 
ATOM   1321 C CG2 . THR A 1 163 ? -2.000  -27.210 19.900  1.00 21.79 ? 163 THR A CG2 1 
ATOM   1322 N N   . CYS A 1 164 ? -4.879  -26.084 22.123  1.00 14.57 ? 164 CYS A N   1 
ATOM   1323 C CA  . CYS A 1 164 ? -6.199  -25.677 21.664  1.00 13.10 ? 164 CYS A CA  1 
ATOM   1324 C C   . CYS A 1 164 ? -6.459  -24.224 22.009  1.00 16.93 ? 164 CYS A C   1 
ATOM   1325 O O   . CYS A 1 164 ? -6.885  -23.438 21.156  1.00 16.53 ? 164 CYS A O   1 
ATOM   1326 C CB  . CYS A 1 164 ? -7.268  -26.582 22.282  1.00 18.88 ? 164 CYS A CB  1 
ATOM   1327 S SG  . CYS A 1 164 ? -8.915  -26.349 21.588  1.00 21.61 ? 164 CYS A SG  1 
ATOM   1328 N N   . VAL A 1 165 ? -6.189  -23.845 23.259  1.00 17.81 ? 165 VAL A N   1 
ATOM   1329 C CA  . VAL A 1 165 ? -6.406  -22.466 23.686  1.00 18.61 ? 165 VAL A CA  1 
ATOM   1330 C C   . VAL A 1 165 ? -5.511  -21.518 22.902  1.00 18.06 ? 165 VAL A C   1 
ATOM   1331 O O   . VAL A 1 165 ? -5.936  -20.436 22.482  1.00 19.40 ? 165 VAL A O   1 
ATOM   1332 C CB  . VAL A 1 165 ? -6.168  -22.342 25.203  1.00 19.29 ? 165 VAL A CB  1 
ATOM   1333 C CG1 . VAL A 1 165 ? -6.253  -20.904 25.627  1.00 20.80 ? 165 VAL A CG1 1 
ATOM   1334 C CG2 . VAL A 1 165 ? -7.197  -23.169 25.962  1.00 22.00 ? 165 VAL A CG2 1 
ATOM   1335 N N   . ASP A 1 166 ? -4.252  -21.899 22.717  1.00 18.43 ? 166 ASP A N   1 
ATOM   1336 C CA  . ASP A 1 166 ? -3.299  -21.044 22.021  1.00 17.22 ? 166 ASP A CA  1 
ATOM   1337 C C   . ASP A 1 166 ? -3.682  -20.883 20.554  1.00 18.44 ? 166 ASP A C   1 
ATOM   1338 O O   . ASP A 1 166 ? -3.658  -19.774 20.010  1.00 16.65 ? 166 ASP A O   1 
ATOM   1339 C CB  . ASP A 1 166 ? -1.909  -21.649 22.132  1.00 20.18 ? 166 ASP A CB  1 
ATOM   1340 C CG  . ASP A 1 166 ? -1.364  -21.623 23.546  1.00 23.55 ? 166 ASP A CG  1 
ATOM   1341 O OD1 . ASP A 1 166 ? -1.890  -20.876 24.407  1.00 25.13 ? 166 ASP A OD1 1 
ATOM   1342 O OD2 . ASP A 1 166 ? -0.414  -22.393 23.788  1.00 23.56 ? 166 ASP A OD2 1 
ATOM   1343 N N   . GLY A 1 167 ? -4.023  -21.989 19.892  1.00 17.95 ? 167 GLY A N   1 
ATOM   1344 C CA  . GLY A 1 167 ? -4.435  -21.904 18.500  1.00 19.36 ? 167 GLY A CA  1 
ATOM   1345 C C   . GLY A 1 167 ? -5.683  -21.062 18.318  1.00 17.02 ? 167 GLY A C   1 
ATOM   1346 O O   . GLY A 1 167 ? -5.752  -20.222 17.415  1.00 16.01 ? 167 GLY A O   1 
ATOM   1347 N N   . LEU A 1 168 ? -6.676  -21.260 19.194  1.00 13.83 ? 168 LEU A N   1 
ATOM   1348 C CA  . LEU A 1 168 ? -7.894  -20.461 19.143  1.00 15.82 ? 168 LEU A CA  1 
ATOM   1349 C C   . LEU A 1 168 ? -7.580  -18.984 19.319  1.00 17.61 ? 168 LEU A C   1 
ATOM   1350 O O   . LEU A 1 168 ? -8.110  -18.139 18.590  1.00 15.64 ? 168 LEU A O   1 
ATOM   1351 C CB  . LEU A 1 168 ? -8.871  -20.937 20.216  1.00 14.69 ? 168 LEU A CB  1 
ATOM   1352 C CG  . LEU A 1 168 ? -10.206 -20.221 20.386  1.00 16.50 ? 168 LEU A CG  1 
ATOM   1353 C CD1 . LEU A 1 168 ? -10.914 -19.939 19.042  1.00 16.47 ? 168 LEU A CD1 1 
ATOM   1354 C CD2 . LEU A 1 168 ? -11.096 -21.021 21.344  1.00 15.20 ? 168 LEU A CD2 1 
ATOM   1355 N N   . ARG A 1 169 ? -6.697  -18.650 20.265  1.00 14.95 ? 169 ARG A N   1 
ATOM   1356 C CA  . ARG A 1 169 ? -6.358  -17.248 20.476  1.00 15.91 ? 169 ARG A CA  1 
ATOM   1357 C C   . ARG A 1 169 ? -5.693  -16.656 19.237  1.00 16.20 ? 169 ARG A C   1 
ATOM   1358 O O   . ARG A 1 169 ? -5.953  -15.502 18.875  1.00 19.80 ? 169 ARG A O   1 
ATOM   1359 C CB  . ARG A 1 169 ? -5.457  -17.115 21.712  1.00 23.91 ? 169 ARG A CB  1 
ATOM   1360 C CG  . ARG A 1 169 ? -4.476  -15.951 21.675  1.00 29.16 ? 169 ARG A CG  1 
ATOM   1361 C CD  . ARG A 1 169 ? -3.744  -15.799 23.020  1.00 32.94 ? 169 ARG A CD  1 
ATOM   1362 N NE  . ARG A 1 169 ? -4.494  -16.383 24.129  1.00 36.96 ? 169 ARG A NE  1 
ATOM   1363 C CZ  . ARG A 1 169 ? -4.020  -17.305 24.959  1.00 41.80 ? 169 ARG A CZ  1 
ATOM   1364 N NH1 . ARG A 1 169 ? -2.797  -17.794 24.824  1.00 35.67 ? 169 ARG A NH1 1 
ATOM   1365 N NH2 . ARG A 1 169 ? -4.797  -17.751 25.946  1.00 41.04 ? 169 ARG A NH2 1 
ATOM   1366 N N   . ARG A 1 170 ? -4.851  -17.440 18.556  1.00 15.20 ? 170 ARG A N   1 
ATOM   1367 C CA  . ARG A 1 170 ? -4.190  -16.947 17.352  1.00 16.54 ? 170 ARG A CA  1 
ATOM   1368 C C   . ARG A 1 170 ? -5.186  -16.757 16.211  1.00 20.23 ? 170 ARG A C   1 
ATOM   1369 O O   . ARG A 1 170 ? -5.113  -15.760 15.480  1.00 18.94 ? 170 ARG A O   1 
ATOM   1370 C CB  . ARG A 1 170 ? -3.060  -17.900 16.954  1.00 19.21 ? 170 ARG A CB  1 
ATOM   1371 C CG  . ARG A 1 170 ? -2.327  -17.542 15.656  1.00 28.18 ? 170 ARG A CG  1 
ATOM   1372 C CD  . ARG A 1 170 ? -1.280  -18.604 15.248  1.00 32.31 ? 170 ARG A CD  1 
ATOM   1373 N NE  . ARG A 1 170 ? -1.905  -19.862 14.853  1.00 33.58 ? 170 ARG A NE  1 
ATOM   1374 C CZ  . ARG A 1 170 ? -1.894  -20.972 15.582  1.00 33.92 ? 170 ARG A CZ  1 
ATOM   1375 N NH1 . ARG A 1 170 ? -1.258  -21.034 16.745  1.00 29.92 ? 170 ARG A NH1 1 
ATOM   1376 N NH2 . ARG A 1 170 ? -2.553  -22.042 15.143  1.00 32.03 ? 170 ARG A NH2 1 
ATOM   1377 N N   . TYR A 1 171 ? -6.135  -17.690 16.048  1.00 16.45 ? 171 TYR A N   1 
ATOM   1378 C CA  . TYR A 1 171 ? -7.138  -17.520 14.995  1.00 19.11 ? 171 TYR A CA  1 
ATOM   1379 C C   . TYR A 1 171 ? -8.012  -16.301 15.259  1.00 14.92 ? 171 TYR A C   1 
ATOM   1380 O O   . TYR A 1 171 ? -8.244  -15.498 14.358  1.00 22.21 ? 171 TYR A O   1 
ATOM   1381 C CB  . TYR A 1 171 ? -8.000  -18.770 14.848  1.00 13.60 ? 171 TYR A CB  1 
ATOM   1382 C CG  . TYR A 1 171 ? -7.215  -20.037 14.603  1.00 15.91 ? 171 TYR A CG  1 
ATOM   1383 C CD1 . TYR A 1 171 ? -6.160  -20.059 13.696  1.00 18.75 ? 171 TYR A CD1 1 
ATOM   1384 C CD2 . TYR A 1 171 ? -7.578  -21.230 15.215  1.00 18.23 ? 171 TYR A CD2 1 
ATOM   1385 C CE1 . TYR A 1 171 ? -5.439  -21.223 13.463  1.00 21.94 ? 171 TYR A CE1 1 
ATOM   1386 C CE2 . TYR A 1 171 ? -6.883  -22.402 14.979  1.00 16.02 ? 171 TYR A CE2 1 
ATOM   1387 C CZ  . TYR A 1 171 ? -5.802  -22.396 14.101  1.00 22.68 ? 171 TYR A CZ  1 
ATOM   1388 O OH  . TYR A 1 171 ? -5.090  -23.564 13.862  1.00 19.09 ? 171 TYR A OH  1 
ATOM   1389 N N   . LEU A 1 172 ? -8.468  -16.120 16.494  1.00 17.11 ? 172 LEU A N   1 
ATOM   1390 C CA  . LEU A 1 172 ? -9.296  -14.956 16.791  1.00 20.54 ? 172 LEU A CA  1 
ATOM   1391 C C   . LEU A 1 172 ? -8.570  -13.654 16.480  1.00 23.32 ? 172 LEU A C   1 
ATOM   1392 O O   . LEU A 1 172 ? -9.205  -12.670 16.095  1.00 22.63 ? 172 LEU A O   1 
ATOM   1393 C CB  . LEU A 1 172 ? -9.736  -14.968 18.251  1.00 17.50 ? 172 LEU A CB  1 
ATOM   1394 C CG  . LEU A 1 172 ? -10.745 -16.028 18.659  1.00 18.60 ? 172 LEU A CG  1 
ATOM   1395 C CD1 . LEU A 1 172 ? -10.828 -16.113 20.172  1.00 19.56 ? 172 LEU A CD1 1 
ATOM   1396 C CD2 . LEU A 1 172 ? -12.108 -15.732 18.039  1.00 18.84 ? 172 LEU A CD2 1 
ATOM   1397 N N   . GLU A 1 173 ? -7.247  -13.625 16.630  1.00 22.85 ? 173 GLU A N   1 
ATOM   1398 C CA  . GLU A 1 173 ? -6.512  -12.413 16.295  1.00 27.50 ? 173 GLU A CA  1 
ATOM   1399 C C   . GLU A 1 173 ? -6.323  -12.274 14.784  1.00 27.44 ? 173 GLU A C   1 
ATOM   1400 O O   . GLU A 1 173 ? -6.575  -11.204 14.218  1.00 29.58 ? 173 GLU A O   1 
ATOM   1401 C CB  . GLU A 1 173 ? -5.174  -12.418 17.033  1.00 27.62 ? 173 GLU A CB  1 
ATOM   1402 C CG  . GLU A 1 173 ? -4.221  -11.296 16.676  1.00 37.58 ? 173 GLU A CG  1 
ATOM   1403 C CD  . GLU A 1 173 ? -4.880  -9.925  16.660  1.00 45.58 ? 173 GLU A CD  1 
ATOM   1404 O OE1 . GLU A 1 173 ? -5.582  -9.572  17.640  1.00 46.48 ? 173 GLU A OE1 1 
ATOM   1405 O OE2 . GLU A 1 173 ? -4.644  -9.177  15.685  1.00 50.61 ? 173 GLU A OE2 1 
ATOM   1406 N N   . ASN A 1 174 ? -5.893  -13.346 14.112  1.00 23.25 ? 174 ASN A N   1 
ATOM   1407 C CA  . ASN A 1 174 ? -5.657  -13.287 12.671  1.00 21.17 ? 174 ASN A CA  1 
ATOM   1408 C C   . ASN A 1 174 ? -6.949  -13.079 11.885  1.00 28.44 ? 174 ASN A C   1 
ATOM   1409 O O   . ASN A 1 174 ? -6.925  -12.491 10.796  1.00 27.04 ? 174 ASN A O   1 
ATOM   1410 C CB  . ASN A 1 174 ? -4.977  -14.567 12.191  1.00 24.61 ? 174 ASN A CB  1 
ATOM   1411 C CG  . ASN A 1 174 ? -3.537  -14.681 12.661  1.00 31.76 ? 174 ASN A CG  1 
ATOM   1412 O OD1 . ASN A 1 174 ? -2.984  -13.743 13.228  1.00 32.77 ? 174 ASN A OD1 1 
ATOM   1413 N ND2 . ASN A 1 174 ? -2.928  -15.843 12.435  1.00 30.34 ? 174 ASN A ND2 1 
ATOM   1414 N N   . GLY A 1 175 ? -8.074  -13.562 12.400  1.00 22.13 ? 175 GLY A N   1 
ATOM   1415 C CA  . GLY A 1 175 ? -9.334  -13.431 11.692  1.00 25.88 ? 175 GLY A CA  1 
ATOM   1416 C C   . GLY A 1 175 ? -10.257 -12.448 12.376  1.00 24.76 ? 175 GLY A C   1 
ATOM   1417 O O   . GLY A 1 175 ? -11.481 -12.552 12.259  1.00 25.38 ? 175 GLY A O   1 
ATOM   1418 N N   . LYS A 1 176 ? -9.652  -11.477 13.072  1.00 23.84 ? 176 LYS A N   1 
ATOM   1419 C CA  . LYS A 1 176 ? -10.387 -10.533 13.913  1.00 27.89 ? 176 LYS A CA  1 
ATOM   1420 C C   . LYS A 1 176 ? -11.560 -9.890  13.174  1.00 26.45 ? 176 LYS A C   1 
ATOM   1421 O O   . LYS A 1 176 ? -12.667 -9.802  13.713  1.00 28.38 ? 176 LYS A O   1 
ATOM   1422 C CB  . LYS A 1 176 ? -9.425  -9.453  14.420  1.00 29.25 ? 176 LYS A CB  1 
ATOM   1423 C CG  . LYS A 1 176 ? -10.006 -8.536  15.485  1.00 38.10 ? 176 LYS A CG  1 
ATOM   1424 C CD  . LYS A 1 176 ? -8.913  -7.687  16.173  1.00 42.91 ? 176 LYS A CD  1 
ATOM   1425 C CE  . LYS A 1 176 ? -9.198  -7.486  17.675  1.00 47.64 ? 176 LYS A CE  1 
ATOM   1426 N NZ  . LYS A 1 176 ? -9.184  -6.050  18.123  1.00 48.83 ? 176 LYS A NZ  1 
ATOM   1427 N N   . GLU A 1 177 ? -11.323 -9.415  11.947  1.00 25.46 ? 177 GLU A N   1 
ATOM   1428 C CA  . GLU A 1 177 ? -12.364 -8.717  11.193  1.00 35.24 ? 177 GLU A CA  1 
ATOM   1429 C C   . GLU A 1 177 ? -13.611 -9.576  11.042  1.00 30.75 ? 177 GLU A C   1 
ATOM   1430 O O   . GLU A 1 177 ? -14.735 -9.079  11.133  1.00 38.59 ? 177 GLU A O   1 
ATOM   1431 C CB  . GLU A 1 177 ? -11.835 -8.322  9.813   1.00 36.84 ? 177 GLU A CB  1 
ATOM   1432 C CG  . GLU A 1 177 ? -11.418 -6.878  9.713   1.00 42.22 ? 177 GLU A CG  1 
ATOM   1433 C CD  . GLU A 1 177 ? -10.439 -6.486  10.801  1.00 47.90 ? 177 GLU A CD  1 
ATOM   1434 O OE1 . GLU A 1 177 ? -10.856 -5.774  11.744  1.00 48.73 ? 177 GLU A OE1 1 
ATOM   1435 O OE2 . GLU A 1 177 ? -9.249  -6.870  10.699  1.00 53.22 ? 177 GLU A OE2 1 
ATOM   1436 N N   . THR A 1 178 ? -13.420 -10.871 10.817  1.00 31.07 ? 178 THR A N   1 
ATOM   1437 C CA  . THR A 1 178 ? -14.479 -11.852 10.628  1.00 30.52 ? 178 THR A CA  1 
ATOM   1438 C C   . THR A 1 178 ? -15.007 -12.387 11.957  1.00 30.19 ? 178 THR A C   1 
ATOM   1439 O O   . THR A 1 178 ? -16.195 -12.260 12.266  1.00 28.39 ? 178 THR A O   1 
ATOM   1440 C CB  . THR A 1 178 ? -13.914 -12.992 9.779   1.00 27.65 ? 178 THR A CB  1 
ATOM   1441 O OG1 . THR A 1 178 ? -13.610 -12.494 8.477   1.00 34.71 ? 178 THR A OG1 1 
ATOM   1442 C CG2 . THR A 1 178 ? -14.879 -14.163 9.679   1.00 32.79 ? 178 THR A CG2 1 
ATOM   1443 N N   . LEU A 1 179 ? -14.115 -12.964 12.763  1.00 24.88 ? 179 LEU A N   1 
ATOM   1444 C CA  . LEU A 1 179 ? -14.512 -13.773 13.907  1.00 22.32 ? 179 LEU A CA  1 
ATOM   1445 C C   . LEU A 1 179 ? -14.984 -12.937 15.083  1.00 26.36 ? 179 LEU A C   1 
ATOM   1446 O O   . LEU A 1 179 ? -15.781 -13.420 15.892  1.00 26.14 ? 179 LEU A O   1 
ATOM   1447 C CB  . LEU A 1 179 ? -13.341 -14.654 14.355  1.00 22.63 ? 179 LEU A CB  1 
ATOM   1448 C CG  . LEU A 1 179 ? -12.840 -15.619 13.282  1.00 23.71 ? 179 LEU A CG  1 
ATOM   1449 C CD1 . LEU A 1 179 ? -11.485 -16.217 13.658  1.00 21.72 ? 179 LEU A CD1 1 
ATOM   1450 C CD2 . LEU A 1 179 ? -13.876 -16.696 13.065  1.00 21.82 ? 179 LEU A CD2 1 
ATOM   1451 N N   . GLN A 1 180 ? -14.497 -11.707 15.222  1.00 24.53 ? 180 GLN A N   1 
ATOM   1452 C CA  . GLN A 1 180 ? -14.844 -10.895 16.378  1.00 26.49 ? 180 GLN A CA  1 
ATOM   1453 C C   . GLN A 1 180 ? -15.832 -9.807  16.058  1.00 33.59 ? 180 GLN A C   1 
ATOM   1454 O O   . GLN A 1 180 ? -15.973 -8.854  16.830  1.00 38.60 ? 180 GLN A O   1 
ATOM   1455 C CB  . GLN A 1 180 ? -13.600 -10.282 17.002  1.00 27.34 ? 180 GLN A CB  1 
ATOM   1456 C CG  . GLN A 1 180 ? -12.736 -11.323 17.622  1.00 24.05 ? 180 GLN A CG  1 
ATOM   1457 C CD  . GLN A 1 180 ? -11.607 -10.713 18.401  1.00 28.09 ? 180 GLN A CD  1 
ATOM   1458 O OE1 . GLN A 1 180 ? -10.466 -10.656 17.937  1.00 34.57 ? 180 GLN A OE1 1 
ATOM   1459 N NE2 . GLN A 1 180 ? -11.928 -10.201 19.580  1.00 30.87 ? 180 GLN A NE2 1 
ATOM   1460 N N   . ARG A 1 181 ? -16.520 -9.911  14.952  1.00 31.41 ? 181 ARG A N   1 
ATOM   1461 C CA  . ARG A 1 181 ? -17.507 -8.894  14.698  1.00 34.34 ? 181 ARG A CA  1 
ATOM   1462 C C   . ARG A 1 181 ? -18.887 -9.460  15.037  1.00 32.42 ? 181 ARG A C   1 
ATOM   1463 O O   . ARG A 1 181 ? -19.080 -10.670 15.198  1.00 31.42 ? 181 ARG A O   1 
ATOM   1464 C CB  . ARG A 1 181 ? -17.372 -8.428  13.248  1.00 37.45 ? 181 ARG A CB  1 
ATOM   1465 C CG  . ARG A 1 181 ? -17.669 -9.501  12.195  1.00 42.19 ? 181 ARG A CG  1 
ATOM   1466 C CD  . ARG A 1 181 ? -19.167 -9.626  11.978  1.00 42.04 ? 181 ARG A CD  1 
ATOM   1467 N NE  . ARG A 1 181 ? -19.538 -10.146 10.667  1.00 47.55 ? 181 ARG A NE  1 
ATOM   1468 C CZ  . ARG A 1 181 ? -19.346 -11.406 10.300  1.00 47.71 ? 181 ARG A CZ  1 
ATOM   1469 N NH1 . ARG A 1 181 ? -18.879 -12.310 11.150  1.00 42.34 ? 181 ARG A NH1 1 
ATOM   1470 N NH2 . ARG A 1 181 ? -19.594 -11.768 9.040   1.00 46.29 ? 181 ARG A NH2 1 
ATOM   1471 N N   . THR A 1 182 ? -19.861 -8.586  15.140  1.00 27.24 ? 182 THR A N   1 
ATOM   1472 C CA  . THR A 1 182 ? -21.199 -9.071  15.403  1.00 31.39 ? 182 THR A CA  1 
ATOM   1473 C C   . THR A 1 182 ? -22.089 -8.414  14.364  1.00 30.62 ? 182 THR A C   1 
ATOM   1474 O O   . THR A 1 182 ? -22.058 -7.188  14.210  1.00 29.73 ? 182 THR A O   1 
ATOM   1475 C CB  . THR A 1 182 ? -21.639 -8.746  16.827  1.00 33.10 ? 182 THR A CB  1 
ATOM   1476 O OG1 . THR A 1 182 ? -20.723 -9.330  17.758  1.00 42.10 ? 182 THR A OG1 1 
ATOM   1477 C CG2 . THR A 1 182 ? -22.920 -9.464  17.077  1.00 33.33 ? 182 THR A CG2 1 
ATOM   1478 N N   . ASP A 1 183 ? -22.783 -9.232  13.572  1.00 24.86 ? 183 ASP A N   1 
ATOM   1479 C CA  . ASP A 1 183 ? -23.741 -8.699  12.618  1.00 23.38 ? 183 ASP A CA  1 
ATOM   1480 C C   . ASP A 1 183 ? -25.122 -8.865  13.217  1.00 22.74 ? 183 ASP A C   1 
ATOM   1481 O O   . ASP A 1 183 ? -25.552 -10.010 13.445  1.00 17.24 ? 183 ASP A O   1 
ATOM   1482 C CB  . ASP A 1 183 ? -23.674 -9.409  11.271  1.00 25.95 ? 183 ASP A CB  1 
ATOM   1483 C CG  . ASP A 1 183 ? -22.344 -9.273  10.595  1.00 37.13 ? 183 ASP A CG  1 
ATOM   1484 O OD1 . ASP A 1 183 ? -21.725 -8.192  10.694  1.00 37.89 ? 183 ASP A OD1 1 
ATOM   1485 O OD2 . ASP A 1 183 ? -21.952 -10.226 9.885   1.00 36.32 ? 183 ASP A OD2 1 
ATOM   1486 N N   . PRO A 1 184 ? -25.828 -7.785  13.527  1.00 23.21 ? 184 PRO A N   1 
ATOM   1487 C CA  . PRO A 1 184 ? -27.163 -7.919  14.078  1.00 21.91 ? 184 PRO A CA  1 
ATOM   1488 C C   . PRO A 1 184 ? -28.136 -8.392  13.012  1.00 16.69 ? 184 PRO A C   1 
ATOM   1489 O O   . PRO A 1 184 ? -27.883 -8.251  11.807  1.00 17.59 ? 184 PRO A O   1 
ATOM   1490 C CB  . PRO A 1 184 ? -27.483 -6.492  14.562  1.00 24.63 ? 184 PRO A CB  1 
ATOM   1491 C CG  . PRO A 1 184 ? -26.548 -5.626  13.744  1.00 24.41 ? 184 PRO A CG  1 
ATOM   1492 C CD  . PRO A 1 184 ? -25.297 -6.436  13.779  1.00 28.10 ? 184 PRO A CD  1 
ATOM   1493 N N   . PRO A 1 185 ? -29.234 -9.011  13.416  1.00 18.99 ? 185 PRO A N   1 
ATOM   1494 C CA  . PRO A 1 185 ? -30.239 -9.431  12.434  1.00 19.99 ? 185 PRO A CA  1 
ATOM   1495 C C   . PRO A 1 185 ? -30.914 -8.239  11.777  1.00 17.91 ? 185 PRO A C   1 
ATOM   1496 O O   . PRO A 1 185 ? -31.236 -7.248  12.431  1.00 18.67 ? 185 PRO A O   1 
ATOM   1497 C CB  . PRO A 1 185 ? -31.237 -10.234 13.274  1.00 17.61 ? 185 PRO A CB  1 
ATOM   1498 C CG  . PRO A 1 185 ? -31.094 -9.696  14.644  1.00 20.17 ? 185 PRO A CG  1 
ATOM   1499 C CD  . PRO A 1 185 ? -29.654 -9.275  14.803  1.00 17.62 ? 185 PRO A CD  1 
ATOM   1500 N N   . LYS A 1 186 ? -31.109 -8.339  10.472  1.00 18.67 ? 186 LYS A N   1 
ATOM   1501 C CA  . LYS A 1 186 ? -32.068 -7.491  9.777   1.00 18.87 ? 186 LYS A CA  1 
ATOM   1502 C C   . LYS A 1 186 ? -33.413 -8.202  9.845   1.00 16.69 ? 186 LYS A C   1 
ATOM   1503 O O   . LYS A 1 186 ? -33.515 -9.367  9.449   1.00 16.22 ? 186 LYS A O   1 
ATOM   1504 C CB  . LYS A 1 186 ? -31.668 -7.277  8.316   1.00 21.63 ? 186 LYS A CB  1 
ATOM   1505 C CG  . LYS A 1 186 ? -30.272 -6.722  8.067   1.00 29.53 ? 186 LYS A CG  1 
ATOM   1506 C CD  . LYS A 1 186 ? -30.138 -6.372  6.584   1.00 38.47 ? 186 LYS A CD  1 
ATOM   1507 C CE  . LYS A 1 186 ? -29.305 -7.412  5.817   1.00 44.94 ? 186 LYS A CE  1 
ATOM   1508 N NZ  . LYS A 1 186 ? -28.199 -6.811  4.997   1.00 43.84 ? 186 LYS A NZ  1 
ATOM   1509 N N   . THR A 1 187 ? -34.438 -7.515  10.346  1.00 15.49 ? 187 THR A N   1 
ATOM   1510 C CA  . THR A 1 187 ? -35.706 -8.155  10.665  1.00 16.34 ? 187 THR A CA  1 
ATOM   1511 C C   . THR A 1 187 ? -36.818 -7.585  9.795   1.00 14.67 ? 187 THR A C   1 
ATOM   1512 O O   . THR A 1 187 ? -36.773 -6.420  9.388   1.00 14.75 ? 187 THR A O   1 
ATOM   1513 C CB  . THR A 1 187 ? -36.072 -7.960  12.149  1.00 16.68 ? 187 THR A CB  1 
ATOM   1514 O OG1 . THR A 1 187 ? -36.045 -6.564  12.462  1.00 18.76 ? 187 THR A OG1 1 
ATOM   1515 C CG2 . THR A 1 187 ? -35.040 -8.658  13.048  1.00 17.09 ? 187 THR A CG2 1 
ATOM   1516 N N   . HIS A 1 188 ? -37.813 -8.417  9.516   1.00 13.72 ? 188 HIS A N   1 
ATOM   1517 C CA  . HIS A 1 188 ? -39.040 -7.950  8.870   1.00 15.63 ? 188 HIS A CA  1 
ATOM   1518 C C   . HIS A 1 188 ? -40.141 -8.951  9.166   1.00 15.81 ? 188 HIS A C   1 
ATOM   1519 O O   . HIS A 1 188 ? -39.889 -10.042 9.675   1.00 14.79 ? 188 HIS A O   1 
ATOM   1520 C CB  . HIS A 1 188 ? -38.851 -7.740  7.360   1.00 13.21 ? 188 HIS A CB  1 
ATOM   1521 C CG  . HIS A 1 188 ? -38.762 -8.996  6.549   1.00 13.24 ? 188 HIS A CG  1 
ATOM   1522 N ND1 . HIS A 1 188 ? -37.569 -9.640  6.296   1.00 15.60 ? 188 HIS A ND1 1 
ATOM   1523 C CD2 . HIS A 1 188 ? -39.707 -9.673  5.850   1.00 16.17 ? 188 HIS A CD2 1 
ATOM   1524 C CE1 . HIS A 1 188 ? -37.787 -10.684 5.516   1.00 14.34 ? 188 HIS A CE1 1 
ATOM   1525 N NE2 . HIS A 1 188 ? -39.077 -10.726 5.227   1.00 18.48 ? 188 HIS A NE2 1 
ATOM   1526 N N   . MET A 1 189 ? -41.378 -8.581  8.850   1.00 14.28 ? 189 MET A N   1 
ATOM   1527 C CA  . MET A 1 189 ? -42.435 -9.566  8.967   1.00 12.88 ? 189 MET A CA  1 
ATOM   1528 C C   . MET A 1 189 ? -43.294 -9.619  7.718   1.00 14.52 ? 189 MET A C   1 
ATOM   1529 O O   . MET A 1 189 ? -43.315 -8.698  6.901   1.00 13.87 ? 189 MET A O   1 
ATOM   1530 C CB  . MET A 1 189 ? -43.273 -9.384  10.251  1.00 21.50 ? 189 MET A CB  1 
ATOM   1531 C CG  . MET A 1 189 ? -43.687 -8.014  10.654  1.00 28.71 ? 189 MET A CG  1 
ATOM   1532 S SD  . MET A 1 189 ? -44.616 -8.164  12.226  1.00 40.63 ? 189 MET A SD  1 
ATOM   1533 C CE  . MET A 1 189 ? -45.318 -9.786  12.034  1.00 23.44 ? 189 MET A CE  1 
ATOM   1534 N N   . THR A 1 190 ? -43.892 -10.780 7.530   1.00 15.06 ? 190 THR A N   1 
ATOM   1535 C CA  . THR A 1 190 ? -44.791 -11.056 6.431   1.00 14.07 ? 190 THR A CA  1 
ATOM   1536 C C   . THR A 1 190 ? -46.137 -11.470 7.006   1.00 15.65 ? 190 THR A C   1 
ATOM   1537 O O   . THR A 1 190 ? -46.251 -11.858 8.169   1.00 13.87 ? 190 THR A O   1 
ATOM   1538 C CB  . THR A 1 190 ? -44.217 -12.118 5.485   1.00 14.86 ? 190 THR A CB  1 
ATOM   1539 O OG1 . THR A 1 190 ? -44.109 -13.379 6.165   1.00 15.51 ? 190 THR A OG1 1 
ATOM   1540 C CG2 . THR A 1 190 ? -42.841 -11.675 4.948   1.00 17.63 ? 190 THR A CG2 1 
ATOM   1541 N N   . HIS A 1 191 ? -47.163 -11.349 6.166   1.00 15.08 ? 191 HIS A N   1 
ATOM   1542 C CA  . HIS A 1 191 ? -48.554 -11.475 6.577   1.00 18.25 ? 191 HIS A CA  1 
ATOM   1543 C C   . HIS A 1 191 ? -49.304 -12.128 5.431   1.00 17.39 ? 191 HIS A C   1 
ATOM   1544 O O   . HIS A 1 191 ? -49.385 -11.540 4.349   1.00 17.36 ? 191 HIS A O   1 
ATOM   1545 C CB  . HIS A 1 191 ? -49.171 -10.109 6.871   1.00 16.83 ? 191 HIS A CB  1 
ATOM   1546 C CG  . HIS A 1 191 ? -50.578 -10.182 7.377   1.00 19.74 ? 191 HIS A CG  1 
ATOM   1547 N ND1 . HIS A 1 191 ? -51.547 -9.285  6.990   1.00 18.73 ? 191 HIS A ND1 1 
ATOM   1548 C CD2 . HIS A 1 191 ? -51.158 -10.993 8.295   1.00 20.35 ? 191 HIS A CD2 1 
ATOM   1549 C CE1 . HIS A 1 191 ? -52.679 -9.573  7.605   1.00 21.39 ? 191 HIS A CE1 1 
ATOM   1550 N NE2 . HIS A 1 191 ? -52.472 -10.606 8.402   1.00 21.56 ? 191 HIS A NE2 1 
ATOM   1551 N N   . HIS A 1 192 ? -49.852 -13.318 5.657   1.00 15.18 ? 192 HIS A N   1 
ATOM   1552 C CA  . HIS A 1 192 ? -50.570 -14.050 4.611   1.00 17.59 ? 192 HIS A CA  1 
ATOM   1553 C C   . HIS A 1 192 ? -51.885 -14.576 5.168   1.00 21.54 ? 192 HIS A C   1 
ATOM   1554 O O   . HIS A 1 192 ? -51.862 -15.447 6.062   1.00 19.24 ? 192 HIS A O   1 
ATOM   1555 C CB  . HIS A 1 192 ? -49.727 -15.208 4.084   1.00 20.23 ? 192 HIS A CB  1 
ATOM   1556 C CG  . HIS A 1 192 ? -48.463 -14.768 3.413   1.00 21.48 ? 192 HIS A CG  1 
ATOM   1557 N ND1 . HIS A 1 192 ? -48.448 -13.958 2.297   1.00 22.79 ? 192 HIS A ND1 1 
ATOM   1558 C CD2 . HIS A 1 192 ? -47.168 -14.987 3.737   1.00 24.64 ? 192 HIS A CD2 1 
ATOM   1559 C CE1 . HIS A 1 192 ? -47.196 -13.723 1.942   1.00 22.93 ? 192 HIS A CE1 1 
ATOM   1560 N NE2 . HIS A 1 192 ? -46.399 -14.333 2.803   1.00 24.77 ? 192 HIS A NE2 1 
ATOM   1561 N N   . PRO A 1 193 ? -53.032 -14.092 4.685   1.00 22.38 ? 193 PRO A N   1 
ATOM   1562 C CA  . PRO A 1 193 ? -54.306 -14.754 5.011   1.00 20.48 ? 193 PRO A CA  1 
ATOM   1563 C C   . PRO A 1 193 ? -54.262 -16.202 4.565   1.00 23.84 ? 193 PRO A C   1 
ATOM   1564 O O   . PRO A 1 193 ? -53.722 -16.520 3.507   1.00 26.74 ? 193 PRO A O   1 
ATOM   1565 C CB  . PRO A 1 193 ? -55.351 -13.958 4.216   1.00 24.40 ? 193 PRO A CB  1 
ATOM   1566 C CG  . PRO A 1 193 ? -54.637 -12.852 3.528   1.00 31.70 ? 193 PRO A CG  1 
ATOM   1567 C CD  . PRO A 1 193 ? -53.192 -12.850 3.909   1.00 22.81 ? 193 PRO A CD  1 
ATOM   1568 N N   . ILE A 1 194 ? -54.795 -17.095 5.396   1.00 22.40 ? 194 ILE A N   1 
ATOM   1569 C CA  . ILE A 1 194 ? -54.959 -18.494 5.004   1.00 26.21 ? 194 ILE A CA  1 
ATOM   1570 C C   . ILE A 1 194 ? -56.418 -18.893 4.898   1.00 35.18 ? 194 ILE A C   1 
ATOM   1571 O O   . ILE A 1 194 ? -56.711 -20.005 4.426   1.00 33.10 ? 194 ILE A O   1 
ATOM   1572 C CB  . ILE A 1 194 ? -54.217 -19.453 5.957   1.00 31.61 ? 194 ILE A CB  1 
ATOM   1573 C CG1 . ILE A 1 194 ? -54.909 -19.509 7.316   1.00 30.70 ? 194 ILE A CG1 1 
ATOM   1574 C CG2 . ILE A 1 194 ? -52.756 -19.056 6.106   1.00 30.57 ? 194 ILE A CG2 1 
ATOM   1575 C CD1 . ILE A 1 194 ? -54.281 -20.527 8.253   1.00 33.11 ? 194 ILE A CD1 1 
ATOM   1576 N N   . SER A 1 195 ? -57.331 -18.030 5.322   1.00 32.33 ? 195 SER A N   1 
ATOM   1577 C CA  . SER A 1 195 ? -58.773 -18.192 5.222   1.00 37.77 ? 195 SER A CA  1 
ATOM   1578 C C   . SER A 1 195 ? -59.350 -16.794 5.355   1.00 38.57 ? 195 SER A C   1 
ATOM   1579 O O   . SER A 1 195 ? -58.608 -15.807 5.376   1.00 41.92 ? 195 SER A O   1 
ATOM   1580 C CB  . SER A 1 195 ? -59.302 -19.130 6.310   1.00 35.70 ? 195 SER A CB  1 
ATOM   1581 O OG  . SER A 1 195 ? -59.253 -20.469 5.872   1.00 49.42 ? 195 SER A OG  1 
ATOM   1582 N N   . ASP A 1 196 ? -60.665 -16.692 5.475   1.00 42.54 ? 196 ASP A N   1 
ATOM   1583 C CA  . ASP A 1 196 ? -61.186 -15.423 5.952   1.00 45.52 ? 196 ASP A CA  1 
ATOM   1584 C C   . ASP A 1 196 ? -61.278 -15.399 7.469   1.00 41.19 ? 196 ASP A C   1 
ATOM   1585 O O   . ASP A 1 196 ? -61.727 -14.400 8.040   1.00 43.64 ? 196 ASP A O   1 
ATOM   1586 C CB  . ASP A 1 196 ? -62.540 -15.107 5.315   1.00 48.60 ? 196 ASP A CB  1 
ATOM   1587 C CG  . ASP A 1 196 ? -62.586 -13.692 4.754   1.00 58.95 ? 196 ASP A CG  1 
ATOM   1588 O OD1 . ASP A 1 196 ? -62.057 -12.779 5.433   1.00 59.71 ? 196 ASP A OD1 1 
ATOM   1589 O OD2 . ASP A 1 196 ? -63.126 -13.493 3.637   1.00 57.79 ? 196 ASP A OD2 1 
ATOM   1590 N N   . HIS A 1 197 ? -60.838 -16.471 8.128   1.00 32.52 ? 197 HIS A N   1 
ATOM   1591 C CA  . HIS A 1 197 ? -60.808 -16.539 9.580   1.00 32.86 ? 197 HIS A CA  1 
ATOM   1592 C C   . HIS A 1 197 ? -59.409 -16.389 10.167  1.00 31.87 ? 197 HIS A C   1 
ATOM   1593 O O   . HIS A 1 197 ? -59.278 -15.938 11.311  1.00 24.88 ? 197 HIS A O   1 
ATOM   1594 C CB  . HIS A 1 197 ? -61.416 -17.862 10.065  1.00 34.48 ? 197 HIS A CB  1 
ATOM   1595 C CG  . HIS A 1 197 ? -62.860 -18.028 9.713   1.00 51.83 ? 197 HIS A CG  1 
ATOM   1596 N ND1 . HIS A 1 197 ? -63.521 -17.178 8.850   1.00 56.64 ? 197 HIS A ND1 1 
ATOM   1597 C CD2 . HIS A 1 197 ? -63.774 -18.947 10.109  1.00 60.40 ? 197 HIS A CD2 1 
ATOM   1598 C CE1 . HIS A 1 197 ? -64.780 -17.564 8.732   1.00 56.74 ? 197 HIS A CE1 1 
ATOM   1599 N NE2 . HIS A 1 197 ? -64.958 -18.636 9.483   1.00 63.33 ? 197 HIS A NE2 1 
ATOM   1600 N N   . GLU A 1 198 ? -58.356 -16.774 9.448   1.00 22.86 ? 198 GLU A N   1 
ATOM   1601 C CA  . GLU A 1 198 ? -57.032 -16.711 10.039  1.00 20.99 ? 198 GLU A CA  1 
ATOM   1602 C C   . GLU A 1 198 ? -55.992 -16.278 9.018   1.00 21.54 ? 198 GLU A C   1 
ATOM   1603 O O   . GLU A 1 198 ? -56.205 -16.331 7.803   1.00 18.63 ? 198 GLU A O   1 
ATOM   1604 C CB  . GLU A 1 198 ? -56.594 -18.043 10.659  1.00 25.23 ? 198 GLU A CB  1 
ATOM   1605 C CG  . GLU A 1 198 ? -57.679 -18.987 11.120  1.00 30.74 ? 198 GLU A CG  1 
ATOM   1606 C CD  . GLU A 1 198 ? -57.095 -20.297 11.620  1.00 32.99 ? 198 GLU A CD  1 
ATOM   1607 O OE1 . GLU A 1 198 ? -56.900 -21.210 10.786  1.00 37.90 ? 198 GLU A OE1 1 
ATOM   1608 O OE2 . GLU A 1 198 ? -56.823 -20.414 12.842  1.00 34.35 ? 198 GLU A OE2 1 
ATOM   1609 N N   . ALA A 1 199 ? -54.841 -15.865 9.549   1.00 17.10 ? 199 ALA A N   1 
ATOM   1610 C CA  . ALA A 1 199 ? -53.716 -15.393 8.760   1.00 13.10 ? 199 ALA A CA  1 
ATOM   1611 C C   . ALA A 1 199 ? -52.435 -15.854 9.428   1.00 17.02 ? 199 ALA A C   1 
ATOM   1612 O O   . ALA A 1 199 ? -52.399 -16.058 10.641  1.00 16.13 ? 199 ALA A O   1 
ATOM   1613 C CB  . ALA A 1 199 ? -53.705 -13.866 8.637   1.00 13.96 ? 199 ALA A CB  1 
ATOM   1614 N N   . THR A 1 200 ? -51.385 -16.014 8.623   1.00 14.52 ? 200 THR A N   1 
ATOM   1615 C CA  . THR A 1 200 ? -50.052 -16.298 9.137   1.00 15.56 ? 200 THR A CA  1 
ATOM   1616 C C   . THR A 1 200 ? -49.291 -14.993 9.310   1.00 16.86 ? 200 THR A C   1 
ATOM   1617 O O   . THR A 1 200 ? -49.326 -14.127 8.425   1.00 14.23 ? 200 THR A O   1 
ATOM   1618 C CB  . THR A 1 200 ? -49.280 -17.213 8.189   1.00 20.16 ? 200 THR A CB  1 
ATOM   1619 O OG1 . THR A 1 200 ? -50.046 -18.391 7.919   1.00 20.46 ? 200 THR A OG1 1 
ATOM   1620 C CG2 . THR A 1 200 ? -47.919 -17.604 8.805   1.00 17.70 ? 200 THR A CG2 1 
ATOM   1621 N N   . LEU A 1 201 ? -48.626 -14.848 10.455  1.00 13.35 ? 201 LEU A N   1 
ATOM   1622 C CA  . LEU A 1 201 ? -47.611 -13.827 10.652  1.00 13.96 ? 201 LEU A CA  1 
ATOM   1623 C C   . LEU A 1 201 ? -46.270 -14.525 10.798  1.00 13.49 ? 201 LEU A C   1 
ATOM   1624 O O   . LEU A 1 201 ? -46.139 -15.464 11.588  1.00 13.68 ? 201 LEU A O   1 
ATOM   1625 C CB  . LEU A 1 201 ? -47.858 -12.972 11.895  1.00 14.26 ? 201 LEU A CB  1 
ATOM   1626 C CG  . LEU A 1 201 ? -49.027 -12.002 11.884  1.00 19.11 ? 201 LEU A CG  1 
ATOM   1627 C CD1 . LEU A 1 201 ? -49.295 -11.536 13.316  1.00 22.11 ? 201 LEU A CD1 1 
ATOM   1628 C CD2 . LEU A 1 201 ? -48.787 -10.834 10.927  1.00 18.03 ? 201 LEU A CD2 1 
ATOM   1629 N N   . ARG A 1 202 ? -45.289 -14.076 10.033  1.00 15.05 ? 202 ARG A N   1 
ATOM   1630 C CA  . ARG A 1 202 ? -43.960 -14.668 10.045  1.00 13.04 ? 202 ARG A CA  1 
ATOM   1631 C C   . ARG A 1 202 ? -42.945 -13.586 10.378  1.00 13.05 ? 202 ARG A C   1 
ATOM   1632 O O   . ARG A 1 202 ? -42.866 -12.558 9.695   1.00 14.49 ? 202 ARG A O   1 
ATOM   1633 C CB  . ARG A 1 202 ? -43.631 -15.324 8.702   1.00 14.61 ? 202 ARG A CB  1 
ATOM   1634 C CG  . ARG A 1 202 ? -42.365 -16.208 8.744   1.00 15.81 ? 202 ARG A CG  1 
ATOM   1635 C CD  . ARG A 1 202 ? -42.256 -17.033 7.456   1.00 15.99 ? 202 ARG A CD  1 
ATOM   1636 N NE  . ARG A 1 202 ? -43.042 -18.259 7.569   1.00 16.61 ? 202 ARG A NE  1 
ATOM   1637 C CZ  . ARG A 1 202 ? -44.116 -18.502 6.831   1.00 18.41 ? 202 ARG A CZ  1 
ATOM   1638 N NH1 . ARG A 1 202 ? -44.523 -17.645 5.909   1.00 17.59 ? 202 ARG A NH1 1 
ATOM   1639 N NH2 . ARG A 1 202 ? -44.805 -19.623 7.038   1.00 18.22 ? 202 ARG A NH2 1 
ATOM   1640 N N   . CYS A 1 203 ? -42.174 -13.827 11.424  1.00 12.40 ? 203 CYS A N   1 
ATOM   1641 C CA  . CYS A 1 203 ? -41.133 -12.934 11.887  1.00 13.80 ? 203 CYS A CA  1 
ATOM   1642 C C   . CYS A 1 203 ? -39.789 -13.443 11.374  1.00 12.75 ? 203 CYS A C   1 
ATOM   1643 O O   . CYS A 1 203 ? -39.415 -14.578 11.673  1.00 12.17 ? 203 CYS A O   1 
ATOM   1644 C CB  . CYS A 1 203 ? -41.148 -12.920 13.408  1.00 18.35 ? 203 CYS A CB  1 
ATOM   1645 S SG  . CYS A 1 203 ? -40.094 -11.740 14.147  1.00 29.81 ? 203 CYS A SG  1 
ATOM   1646 N N   . TRP A 1 204 ? -39.064 -12.607 10.632  1.00 10.93 ? 204 TRP A N   1 
ATOM   1647 C CA  . TRP A 1 204 ? -37.826 -12.999 9.963   1.00 10.73 ? 204 TRP A CA  1 
ATOM   1648 C C   . TRP A 1 204 ? -36.620 -12.322 10.601  1.00 12.84 ? 204 TRP A C   1 
ATOM   1649 O O   . TRP A 1 204 ? -36.663 -11.129 10.914  1.00 13.36 ? 204 TRP A O   1 
ATOM   1650 C CB  . TRP A 1 204 ? -37.847 -12.607 8.498   1.00 13.04 ? 204 TRP A CB  1 
ATOM   1651 C CG  . TRP A 1 204 ? -38.651 -13.460 7.596   1.00 15.31 ? 204 TRP A CG  1 
ATOM   1652 C CD1 . TRP A 1 204 ? -39.991 -13.336 7.312   1.00 15.52 ? 204 TRP A CD1 1 
ATOM   1653 C CD2 . TRP A 1 204 ? -38.169 -14.535 6.794   1.00 14.63 ? 204 TRP A CD2 1 
ATOM   1654 N NE1 . TRP A 1 204 ? -40.366 -14.285 6.392   1.00 13.68 ? 204 TRP A NE1 1 
ATOM   1655 C CE2 . TRP A 1 204 ? -39.263 -15.027 6.052   1.00 18.48 ? 204 TRP A CE2 1 
ATOM   1656 C CE3 . TRP A 1 204 ? -36.919 -15.129 6.629   1.00 17.45 ? 204 TRP A CE3 1 
ATOM   1657 C CZ2 . TRP A 1 204 ? -39.142 -16.092 5.169   1.00 20.54 ? 204 TRP A CZ2 1 
ATOM   1658 C CZ3 . TRP A 1 204 ? -36.800 -16.183 5.748   1.00 22.27 ? 204 TRP A CZ3 1 
ATOM   1659 C CH2 . TRP A 1 204 ? -37.906 -16.657 5.037   1.00 21.17 ? 204 TRP A CH2 1 
ATOM   1660 N N   . ALA A 1 205 ? -35.527 -13.070 10.744  1.00 12.78 ? 205 ALA A N   1 
ATOM   1661 C CA  . ALA A 1 205 ? -34.231 -12.509 11.129  1.00 12.45 ? 205 ALA A CA  1 
ATOM   1662 C C   . ALA A 1 205 ? -33.216 -12.939 10.079  1.00 11.27 ? 205 ALA A C   1 
ATOM   1663 O O   . ALA A 1 205 ? -33.058 -14.136 9.833   1.00 11.12 ? 205 ALA A O   1 
ATOM   1664 C CB  . ALA A 1 205 ? -33.806 -12.995 12.518  1.00 11.96 ? 205 ALA A CB  1 
ATOM   1665 N N   . LEU A 1 206 ? -32.569 -11.980 9.428   1.00 11.08 ? 206 LEU A N   1 
ATOM   1666 C CA  . LEU A 1 206 ? -31.649 -12.287 8.342   1.00 14.68 ? 206 LEU A CA  1 
ATOM   1667 C C   . LEU A 1 206 ? -30.292 -11.637 8.574   1.00 15.68 ? 206 LEU A C   1 
ATOM   1668 O O   . LEU A 1 206 ? -30.186 -10.598 9.225   1.00 17.55 ? 206 LEU A O   1 
ATOM   1669 C CB  . LEU A 1 206 ? -32.177 -11.844 6.971   1.00 14.31 ? 206 LEU A CB  1 
ATOM   1670 C CG  . LEU A 1 206 ? -33.530 -12.397 6.505   1.00 16.11 ? 206 LEU A CG  1 
ATOM   1671 C CD1 . LEU A 1 206 ? -34.050 -11.609 5.308   1.00 20.65 ? 206 LEU A CD1 1 
ATOM   1672 C CD2 . LEU A 1 206 ? -33.377 -13.862 6.131   1.00 17.00 ? 206 LEU A CD2 1 
ATOM   1673 N N   . GLY A 1 207 ? -29.260 -12.264 8.013   1.00 15.61 ? 207 GLY A N   1 
ATOM   1674 C CA  . GLY A 1 207 ? -27.940 -11.667 7.938   1.00 18.96 ? 207 GLY A CA  1 
ATOM   1675 C C   . GLY A 1 207 ? -27.177 -11.572 9.240   1.00 18.96 ? 207 GLY A C   1 
ATOM   1676 O O   . GLY A 1 207 ? -26.336 -10.682 9.383   1.00 18.69 ? 207 GLY A O   1 
ATOM   1677 N N   . PHE A 1 208 ? -27.430 -12.458 10.197  1.00 13.97 ? 208 PHE A N   1 
ATOM   1678 C CA  . PHE A 1 208 ? -26.855 -12.256 11.512  1.00 14.99 ? 208 PHE A CA  1 
ATOM   1679 C C   . PHE A 1 208 ? -25.698 -13.229 11.748  1.00 15.88 ? 208 PHE A C   1 
ATOM   1680 O O   . PHE A 1 208 ? -25.580 -14.270 11.094  1.00 13.36 ? 208 PHE A O   1 
ATOM   1681 C CB  . PHE A 1 208 ? -27.928 -12.348 12.620  1.00 15.26 ? 208 PHE A CB  1 
ATOM   1682 C CG  . PHE A 1 208 ? -28.683 -13.651 12.665  1.00 14.73 ? 208 PHE A CG  1 
ATOM   1683 C CD1 . PHE A 1 208 ? -28.201 -14.719 13.414  1.00 12.98 ? 208 PHE A CD1 1 
ATOM   1684 C CD2 . PHE A 1 208 ? -29.881 -13.805 11.979  1.00 14.25 ? 208 PHE A CD2 1 
ATOM   1685 C CE1 . PHE A 1 208 ? -28.891 -15.919 13.464  1.00 12.56 ? 208 PHE A CE1 1 
ATOM   1686 C CE2 . PHE A 1 208 ? -30.581 -15.001 12.029  1.00 13.30 ? 208 PHE A CE2 1 
ATOM   1687 C CZ  . PHE A 1 208 ? -30.087 -16.060 12.761  1.00 14.59 ? 208 PHE A CZ  1 
ATOM   1688 N N   . TYR A 1 209 ? -24.818 -12.840 12.668  1.00 13.07 ? 209 TYR A N   1 
ATOM   1689 C CA  . TYR A 1 209 ? -23.653 -13.613 13.111  1.00 17.57 ? 209 TYR A CA  1 
ATOM   1690 C C   . TYR A 1 209 ? -23.308 -13.147 14.512  1.00 14.16 ? 209 TYR A C   1 
ATOM   1691 O O   . TYR A 1 209 ? -23.275 -11.937 14.753  1.00 15.67 ? 209 TYR A O   1 
ATOM   1692 C CB  . TYR A 1 209 ? -22.427 -13.424 12.209  1.00 16.46 ? 209 TYR A CB  1 
ATOM   1693 C CG  . TYR A 1 209 ? -21.304 -14.366 12.616  1.00 18.60 ? 209 TYR A CG  1 
ATOM   1694 C CD1 . TYR A 1 209 ? -20.348 -13.991 13.567  1.00 19.22 ? 209 TYR A CD1 1 
ATOM   1695 C CD2 . TYR A 1 209 ? -21.236 -15.651 12.091  1.00 19.03 ? 209 TYR A CD2 1 
ATOM   1696 C CE1 . TYR A 1 209 ? -19.349 -14.870 13.956  1.00 16.26 ? 209 TYR A CE1 1 
ATOM   1697 C CE2 . TYR A 1 209 ? -20.234 -16.532 12.468  1.00 17.68 ? 209 TYR A CE2 1 
ATOM   1698 C CZ  . TYR A 1 209 ? -19.301 -16.137 13.403  1.00 16.43 ? 209 TYR A CZ  1 
ATOM   1699 O OH  . TYR A 1 209 ? -18.318 -17.029 13.777  1.00 15.94 ? 209 TYR A OH  1 
ATOM   1700 N N   . PRO A 1 210 ? -23.037 -14.051 15.456  1.00 14.37 ? 210 PRO A N   1 
ATOM   1701 C CA  . PRO A 1 210 ? -23.030 -15.518 15.338  1.00 16.88 ? 210 PRO A CA  1 
ATOM   1702 C C   . PRO A 1 210 ? -24.418 -16.131 15.259  1.00 17.87 ? 210 PRO A C   1 
ATOM   1703 O O   . PRO A 1 210 ? -25.426 -15.422 15.214  1.00 15.96 ? 210 PRO A O   1 
ATOM   1704 C CB  . PRO A 1 210 ? -22.266 -15.961 16.598  1.00 17.79 ? 210 PRO A CB  1 
ATOM   1705 C CG  . PRO A 1 210 ? -22.451 -14.867 17.580  1.00 22.00 ? 210 PRO A CG  1 
ATOM   1706 C CD  . PRO A 1 210 ? -22.512 -13.605 16.762  1.00 20.88 ? 210 PRO A CD  1 
ATOM   1707 N N   . ALA A 1 211 ? -24.490 -17.463 15.207  1.00 14.25 ? 211 ALA A N   1 
ATOM   1708 C CA  . ALA A 1 211 ? -25.742 -18.121 14.863  1.00 18.70 ? 211 ALA A CA  1 
ATOM   1709 C C   . ALA A 1 211 ? -26.746 -18.114 16.009  1.00 19.26 ? 211 ALA A C   1 
ATOM   1710 O O   . ALA A 1 211 ? -27.948 -18.254 15.760  1.00 19.58 ? 211 ALA A O   1 
ATOM   1711 C CB  . ALA A 1 211 ? -25.479 -19.559 14.409  1.00 16.42 ? 211 ALA A CB  1 
ATOM   1712 N N   . GLU A 1 212 ? -26.297 -17.920 17.243  1.00 15.59 ? 212 GLU A N   1 
ATOM   1713 C CA  . GLU A 1 212 ? -27.225 -17.975 18.366  1.00 22.59 ? 212 GLU A CA  1 
ATOM   1714 C C   . GLU A 1 212 ? -28.232 -16.831 18.289  1.00 16.74 ? 212 GLU A C   1 
ATOM   1715 O O   . GLU A 1 212 ? -27.853 -15.670 18.119  1.00 15.66 ? 212 GLU A O   1 
ATOM   1716 C CB  . GLU A 1 212 ? -26.479 -17.904 19.696  1.00 20.07 ? 212 GLU A CB  1 
ATOM   1717 C CG  . GLU A 1 212 ? -27.422 -17.483 20.804  1.00 26.63 ? 212 GLU A CG  1 
ATOM   1718 C CD  . GLU A 1 212 ? -28.221 -18.660 21.340  1.00 34.22 ? 212 GLU A CD  1 
ATOM   1719 O OE1 . GLU A 1 212 ? -28.032 -19.789 20.825  1.00 36.88 ? 212 GLU A OE1 1 
ATOM   1720 O OE2 . GLU A 1 212 ? -29.103 -18.445 22.213  1.00 42.72 ? 212 GLU A OE2 1 
ATOM   1721 N N   . ILE A 1 213 ? -29.518 -17.150 18.431  1.00 16.16 ? 213 ILE A N   1 
ATOM   1722 C CA  . ILE A 1 213 ? -30.564 -16.131 18.363  1.00 19.61 ? 213 ILE A CA  1 
ATOM   1723 C C   . ILE A 1 213 ? -31.829 -16.689 19.013  1.00 18.40 ? 213 ILE A C   1 
ATOM   1724 O O   . ILE A 1 213 ? -32.034 -17.905 19.077  1.00 17.90 ? 213 ILE A O   1 
ATOM   1725 C CB  . ILE A 1 213 ? -30.808 -15.691 16.894  1.00 13.58 ? 213 ILE A CB  1 
ATOM   1726 C CG1 . ILE A 1 213 ? -31.669 -14.427 16.831  1.00 15.95 ? 213 ILE A CG1 1 
ATOM   1727 C CG2 . ILE A 1 213 ? -31.454 -16.817 16.084  1.00 15.45 ? 213 ILE A CG2 1 
ATOM   1728 C CD1 . ILE A 1 213 ? -31.574 -13.675 15.496  1.00 18.52 ? 213 ILE A CD1 1 
ATOM   1729 N N   . THR A 1 214 ? -32.683 -15.797 19.513  1.00 14.31 ? 214 THR A N   1 
ATOM   1730 C CA  . THR A 1 214 ? -33.981 -16.205 20.040  1.00 18.50 ? 214 THR A CA  1 
ATOM   1731 C C   . THR A 1 214 ? -35.066 -15.380 19.370  1.00 15.00 ? 214 THR A C   1 
ATOM   1732 O O   . THR A 1 214 ? -35.006 -14.146 19.394  1.00 16.52 ? 214 THR A O   1 
ATOM   1733 C CB  . THR A 1 214 ? -34.050 -16.044 21.558  1.00 20.21 ? 214 THR A CB  1 
ATOM   1734 O OG1 . THR A 1 214 ? -32.976 -16.772 22.154  1.00 26.05 ? 214 THR A OG1 1 
ATOM   1735 C CG2 . THR A 1 214 ? -35.366 -16.603 22.067  1.00 23.55 ? 214 THR A CG2 1 
ATOM   1736 N N   . LEU A 1 215 ? -36.030 -16.063 18.746  1.00 16.69 ? 215 LEU A N   1 
ATOM   1737 C CA  . LEU A 1 215 ? -37.235 -15.438 18.207  1.00 16.35 ? 215 LEU A CA  1 
ATOM   1738 C C   . LEU A 1 215 ? -38.425 -16.033 18.926  1.00 17.63 ? 215 LEU A C   1 
ATOM   1739 O O   . LEU A 1 215 ? -38.595 -17.255 18.942  1.00 18.89 ? 215 LEU A O   1 
ATOM   1740 C CB  . LEU A 1 215 ? -37.422 -15.670 16.709  1.00 16.86 ? 215 LEU A CB  1 
ATOM   1741 C CG  . LEU A 1 215 ? -36.339 -15.329 15.718  1.00 18.28 ? 215 LEU A CG  1 
ATOM   1742 C CD1 . LEU A 1 215 ? -36.627 -16.102 14.418  1.00 17.47 ? 215 LEU A CD1 1 
ATOM   1743 C CD2 . LEU A 1 215 ? -36.316 -13.838 15.505  1.00 21.90 ? 215 LEU A CD2 1 
ATOM   1744 N N   . THR A 1 216 ? -39.237 -15.179 19.524  1.00 17.10 ? 216 THR A N   1 
ATOM   1745 C CA  . THR A 1 216 ? -40.386 -15.641 20.279  1.00 19.59 ? 216 THR A CA  1 
ATOM   1746 C C   . THR A 1 216 ? -41.575 -14.761 19.933  1.00 20.23 ? 216 THR A C   1 
ATOM   1747 O O   . THR A 1 216 ? -41.414 -13.557 19.723  1.00 19.67 ? 216 THR A O   1 
ATOM   1748 C CB  . THR A 1 216 ? -40.135 -15.577 21.787  1.00 20.49 ? 216 THR A CB  1 
ATOM   1749 O OG1 . THR A 1 216 ? -39.789 -14.239 22.134  1.00 28.25 ? 216 THR A OG1 1 
ATOM   1750 C CG2 . THR A 1 216 ? -39.005 -16.490 22.195  1.00 22.95 ? 216 THR A CG2 1 
ATOM   1751 N N   . TRP A 1 217 ? -42.754 -15.372 19.881  1.00 19.61 ? 217 TRP A N   1 
ATOM   1752 C CA  . TRP A 1 217 ? -44.017 -14.683 19.641  1.00 17.62 ? 217 TRP A CA  1 
ATOM   1753 C C   . TRP A 1 217 ? -44.766 -14.574 20.969  1.00 20.19 ? 217 TRP A C   1 
ATOM   1754 O O   . TRP A 1 217 ? -44.873 -15.561 21.706  1.00 21.45 ? 217 TRP A O   1 
ATOM   1755 C CB  . TRP A 1 217 ? -44.856 -15.467 18.628  1.00 17.11 ? 217 TRP A CB  1 
ATOM   1756 C CG  . TRP A 1 217 ? -44.604 -15.105 17.198  1.00 19.59 ? 217 TRP A CG  1 
ATOM   1757 C CD1 . TRP A 1 217 ? -44.017 -15.903 16.250  1.00 18.96 ? 217 TRP A CD1 1 
ATOM   1758 C CD2 . TRP A 1 217 ? -45.000 -13.900 16.514  1.00 18.20 ? 217 TRP A CD2 1 
ATOM   1759 N NE1 . TRP A 1 217 ? -43.970 -15.249 15.042  1.00 16.33 ? 217 TRP A NE1 1 
ATOM   1760 C CE2 . TRP A 1 217 ? -44.574 -14.024 15.172  1.00 14.85 ? 217 TRP A CE2 1 
ATOM   1761 C CE3 . TRP A 1 217 ? -45.651 -12.724 16.911  1.00 16.11 ? 217 TRP A CE3 1 
ATOM   1762 C CZ2 . TRP A 1 217 ? -44.777 -13.016 14.224  1.00 14.37 ? 217 TRP A CZ2 1 
ATOM   1763 C CZ3 . TRP A 1 217 ? -45.850 -11.725 15.974  1.00 14.85 ? 217 TRP A CZ3 1 
ATOM   1764 C CH2 . TRP A 1 217 ? -45.418 -11.880 14.642  1.00 16.45 ? 217 TRP A CH2 1 
ATOM   1765 N N   . GLN A 1 218 ? -45.271 -13.382 21.277  1.00 17.96 ? 218 GLN A N   1 
ATOM   1766 C CA  . GLN A 1 218 ? -46.171 -13.178 22.407  1.00 17.31 ? 218 GLN A CA  1 
ATOM   1767 C C   . GLN A 1 218 ? -47.545 -12.744 21.898  1.00 20.51 ? 218 GLN A C   1 
ATOM   1768 O O   . GLN A 1 218 ? -47.656 -12.076 20.865  1.00 16.61 ? 218 GLN A O   1 
ATOM   1769 C CB  . GLN A 1 218 ? -45.639 -12.106 23.338  1.00 17.42 ? 218 GLN A CB  1 
ATOM   1770 C CG  . GLN A 1 218 ? -44.296 -12.465 23.928  1.00 22.42 ? 218 GLN A CG  1 
ATOM   1771 C CD  . GLN A 1 218 ? -43.820 -11.463 24.945  1.00 27.52 ? 218 GLN A CD  1 
ATOM   1772 O OE1 . GLN A 1 218 ? -44.401 -10.393 25.105  1.00 23.69 ? 218 GLN A OE1 1 
ATOM   1773 N NE2 . GLN A 1 218 ? -42.713 -11.781 25.601  1.00 28.43 ? 218 GLN A NE2 1 
ATOM   1774 N N   . ARG A 1 219 ? -48.587 -13.123 22.633  1.00 18.30 ? 219 ARG A N   1 
ATOM   1775 C CA  . ARG A 1 219 ? -49.937 -12.619 22.406  1.00 20.76 ? 219 ARG A CA  1 
ATOM   1776 C C   . ARG A 1 219 ? -50.379 -11.896 23.662  1.00 23.78 ? 219 ARG A C   1 
ATOM   1777 O O   . ARG A 1 219 ? -50.456 -12.513 24.729  1.00 22.72 ? 219 ARG A O   1 
ATOM   1778 C CB  . ARG A 1 219 ? -50.926 -13.735 22.085  1.00 21.49 ? 219 ARG A CB  1 
ATOM   1779 C CG  . ARG A 1 219 ? -52.292 -13.200 21.654  1.00 22.04 ? 219 ARG A CG  1 
ATOM   1780 C CD  . ARG A 1 219 ? -53.302 -14.317 21.539  1.00 23.24 ? 219 ARG A CD  1 
ATOM   1781 N NE  . ARG A 1 219 ? -53.461 -15.001 22.814  1.00 26.15 ? 219 ARG A NE  1 
ATOM   1782 C CZ  . ARG A 1 219 ? -53.923 -16.238 22.954  1.00 28.52 ? 219 ARG A CZ  1 
ATOM   1783 N NH1 . ARG A 1 219 ? -54.383 -16.929 21.919  1.00 32.68 ? 219 ARG A NH1 1 
ATOM   1784 N NH2 . ARG A 1 219 ? -53.945 -16.789 24.166  1.00 32.77 ? 219 ARG A NH2 1 
ATOM   1785 N N   . ASP A 1 220 ? -50.681 -10.604 23.527  1.00 20.22 ? 220 ASP A N   1 
ATOM   1786 C CA  . ASP A 1 220 ? -50.986 -9.745  24.666  1.00 25.14 ? 220 ASP A CA  1 
ATOM   1787 C C   . ASP A 1 220 ? -49.976 -9.954  25.793  1.00 24.29 ? 220 ASP A C   1 
ATOM   1788 O O   . ASP A 1 220 ? -50.339 -10.048 26.966  1.00 25.11 ? 220 ASP A O   1 
ATOM   1789 C CB  . ASP A 1 220 ? -52.412 -9.980  25.168  1.00 21.08 ? 220 ASP A CB  1 
ATOM   1790 C CG  . ASP A 1 220 ? -53.469 -9.413  24.225  1.00 29.12 ? 220 ASP A CG  1 
ATOM   1791 O OD1 . ASP A 1 220 ? -53.257 -8.307  23.678  1.00 32.00 ? 220 ASP A OD1 1 
ATOM   1792 O OD2 . ASP A 1 220 ? -54.508 -10.075 24.027  1.00 26.57 ? 220 ASP A OD2 1 
ATOM   1793 N N   . GLY A 1 221 ? -48.698 -10.081 25.429  1.00 24.58 ? 221 GLY A N   1 
ATOM   1794 C CA  . GLY A 1 221 ? -47.626 -10.187 26.405  1.00 22.83 ? 221 GLY A CA  1 
ATOM   1795 C C   . GLY A 1 221 ? -47.327 -11.581 26.924  1.00 25.66 ? 221 GLY A C   1 
ATOM   1796 O O   . GLY A 1 221 ? -46.413 -11.730 27.742  1.00 32.57 ? 221 GLY A O   1 
ATOM   1797 N N   . GLU A 1 222 ? -48.047 -12.603 26.469  1.00 25.77 ? 222 GLU A N   1 
ATOM   1798 C CA  . GLU A 1 222 ? -47.919 -13.980 26.936  1.00 27.06 ? 222 GLU A CA  1 
ATOM   1799 C C   . GLU A 1 222 ? -47.218 -14.806 25.863  1.00 29.16 ? 222 GLU A C   1 
ATOM   1800 O O   . GLU A 1 222 ? -47.641 -14.796 24.705  1.00 22.83 ? 222 GLU A O   1 
ATOM   1801 C CB  . GLU A 1 222 ? -49.306 -14.567 27.206  1.00 29.18 ? 222 GLU A CB  1 
ATOM   1802 C CG  . GLU A 1 222 ? -50.133 -13.798 28.237  1.00 40.56 ? 222 GLU A CG  1 
ATOM   1803 C CD  . GLU A 1 222 ? -50.865 -14.705 29.216  1.00 50.38 ? 222 GLU A CD  1 
ATOM   1804 O OE1 . GLU A 1 222 ? -51.714 -15.503 28.747  1.00 50.42 ? 222 GLU A OE1 1 
ATOM   1805 O OE2 . GLU A 1 222 ? -50.595 -14.631 30.437  1.00 50.59 ? 222 GLU A OE2 1 
ATOM   1806 N N   . ASP A 1 223 ? -46.174 -15.538 26.249  1.00 26.24 ? 223 ASP A N   1 
ATOM   1807 C CA  . ASP A 1 223 ? -45.388 -16.293 25.278  1.00 27.02 ? 223 ASP A CA  1 
ATOM   1808 C C   . ASP A 1 223 ? -46.257 -17.356 24.617  1.00 30.39 ? 223 ASP A C   1 
ATOM   1809 O O   . ASP A 1 223 ? -47.030 -18.047 25.285  1.00 31.87 ? 223 ASP A O   1 
ATOM   1810 C CB  . ASP A 1 223 ? -44.192 -16.956 25.974  1.00 30.36 ? 223 ASP A CB  1 
ATOM   1811 C CG  . ASP A 1 223 ? -42.942 -16.082 25.964  1.00 34.83 ? 223 ASP A CG  1 
ATOM   1812 O OD1 . ASP A 1 223 ? -43.076 -14.843 26.052  1.00 38.91 ? 223 ASP A OD1 1 
ATOM   1813 O OD2 . ASP A 1 223 ? -41.821 -16.632 25.894  1.00 45.99 ? 223 ASP A OD2 1 
ATOM   1814 N N   . GLN A 1 224 ? -46.143 -17.480 23.301  1.00 25.04 ? 224 GLN A N   1 
ATOM   1815 C CA  . GLN A 1 224 ? -46.967 -18.421 22.546  1.00 29.60 ? 224 GLN A CA  1 
ATOM   1816 C C   . GLN A 1 224 ? -46.171 -19.666 22.164  1.00 33.31 ? 224 GLN A C   1 
ATOM   1817 O O   . GLN A 1 224 ? -46.106 -20.055 21.003  1.00 33.68 ? 224 GLN A O   1 
ATOM   1818 C CB  . GLN A 1 224 ? -47.537 -17.738 21.310  1.00 32.45 ? 224 GLN A CB  1 
ATOM   1819 C CG  . GLN A 1 224 ? -48.590 -16.729 21.661  1.00 29.10 ? 224 GLN A CG  1 
ATOM   1820 C CD  . GLN A 1 224 ? -49.906 -17.384 21.937  1.00 32.21 ? 224 GLN A CD  1 
ATOM   1821 O OE1 . GLN A 1 224 ? -50.505 -18.005 21.053  1.00 37.46 ? 224 GLN A OE1 1 
ATOM   1822 N NE2 . GLN A 1 224 ? -50.363 -17.278 23.182  1.00 35.51 ? 224 GLN A NE2 1 
ATOM   1823 N N   . THR A 1 225 ? -45.585 -20.306 23.181  1.00 40.36 ? 225 THR A N   1 
ATOM   1824 C CA  . THR A 1 225 ? -44.617 -21.376 22.945  1.00 44.32 ? 225 THR A CA  1 
ATOM   1825 C C   . THR A 1 225 ? -45.181 -22.470 22.045  1.00 45.19 ? 225 THR A C   1 
ATOM   1826 O O   . THR A 1 225 ? -44.591 -22.803 21.010  1.00 48.76 ? 225 THR A O   1 
ATOM   1827 C CB  . THR A 1 225 ? -44.160 -21.969 24.277  1.00 46.06 ? 225 THR A CB  1 
ATOM   1828 O OG1 . THR A 1 225 ? -43.610 -20.930 25.099  1.00 45.92 ? 225 THR A OG1 1 
ATOM   1829 C CG2 . THR A 1 225 ? -43.104 -23.042 24.046  1.00 48.19 ? 225 THR A CG2 1 
ATOM   1830 N N   . GLN A 1 226 ? -46.329 -23.036 22.408  1.00 45.25 ? 226 GLN A N   1 
ATOM   1831 C CA  . GLN A 1 226 ? -46.820 -24.229 21.733  1.00 46.74 ? 226 GLN A CA  1 
ATOM   1832 C C   . GLN A 1 226 ? -47.665 -23.941 20.490  1.00 45.08 ? 226 GLN A C   1 
ATOM   1833 O O   . GLN A 1 226 ? -48.207 -24.882 19.902  1.00 50.46 ? 226 GLN A O   1 
ATOM   1834 C CB  . GLN A 1 226 ? -47.618 -25.098 22.709  1.00 51.48 ? 226 GLN A CB  1 
ATOM   1835 C CG  . GLN A 1 226 ? -46.883 -26.367 23.120  1.00 60.36 ? 226 GLN A CG  1 
ATOM   1836 C CD  . GLN A 1 226 ? -47.821 -27.461 23.604  1.00 65.15 ? 226 GLN A CD  1 
ATOM   1837 O OE1 . GLN A 1 226 ? -48.484 -27.319 24.633  1.00 69.90 ? 226 GLN A OE1 1 
ATOM   1838 N NE2 . GLN A 1 226 ? -47.884 -28.560 22.857  1.00 61.79 ? 226 GLN A NE2 1 
ATOM   1839 N N   . ASP A 1 227 ? -47.794 -22.685 20.067  1.00 37.14 ? 227 ASP A N   1 
ATOM   1840 C CA  . ASP A 1 227 ? -48.483 -22.381 18.815  1.00 39.44 ? 227 ASP A CA  1 
ATOM   1841 C C   . ASP A 1 227 ? -47.566 -21.789 17.758  1.00 38.08 ? 227 ASP A C   1 
ATOM   1842 O O   . ASP A 1 227 ? -48.042 -21.430 16.674  1.00 31.68 ? 227 ASP A O   1 
ATOM   1843 C CB  . ASP A 1 227 ? -49.658 -21.429 19.054  1.00 31.63 ? 227 ASP A CB  1 
ATOM   1844 C CG  . ASP A 1 227 ? -50.889 -22.150 19.547  1.00 50.01 ? 227 ASP A CG  1 
ATOM   1845 O OD1 . ASP A 1 227 ? -50.951 -22.479 20.754  1.00 47.51 ? 227 ASP A OD1 1 
ATOM   1846 O OD2 . ASP A 1 227 ? -51.796 -22.385 18.718  1.00 55.35 ? 227 ASP A OD2 1 
ATOM   1847 N N   . THR A 1 228 ? -46.271 -21.688 18.035  1.00 33.45 ? 228 THR A N   1 
ATOM   1848 C CA  . THR A 1 228 ? -45.333 -21.086 17.107  1.00 28.94 ? 228 THR A CA  1 
ATOM   1849 C C   . THR A 1 228 ? -44.673 -22.162 16.256  1.00 34.52 ? 228 THR A C   1 
ATOM   1850 O O   . THR A 1 228 ? -44.288 -23.217 16.766  1.00 36.70 ? 228 THR A O   1 
ATOM   1851 C CB  . THR A 1 228 ? -44.267 -20.303 17.870  1.00 33.27 ? 228 THR A CB  1 
ATOM   1852 O OG1 . THR A 1 228 ? -44.904 -19.406 18.783  1.00 36.48 ? 228 THR A OG1 1 
ATOM   1853 C CG2 . THR A 1 228 ? -43.400 -19.508 16.914  1.00 30.64 ? 228 THR A CG2 1 
ATOM   1854 N N   . GLU A 1 229 ? -44.568 -21.906 14.953  1.00 26.10 ? 229 GLU A N   1 
ATOM   1855 C CA  . GLU A 1 229 ? -43.708 -22.705 14.092  1.00 24.80 ? 229 GLU A CA  1 
ATOM   1856 C C   . GLU A 1 229 ? -42.346 -22.027 14.006  1.00 25.08 ? 229 GLU A C   1 
ATOM   1857 O O   . GLU A 1 229 ? -42.241 -20.857 13.618  1.00 19.17 ? 229 GLU A O   1 
ATOM   1858 C CB  . GLU A 1 229 ? -44.303 -22.891 12.700  1.00 29.84 ? 229 GLU A CB  1 
ATOM   1859 C CG  . GLU A 1 229 ? -43.237 -23.281 11.696  1.00 31.36 ? 229 GLU A CG  1 
ATOM   1860 C CD  . GLU A 1 229 ? -43.769 -24.052 10.513  1.00 38.14 ? 229 GLU A CD  1 
ATOM   1861 O OE1 . GLU A 1 229 ? -43.188 -25.116 10.192  1.00 40.90 ? 229 GLU A OE1 1 
ATOM   1862 O OE2 . GLU A 1 229 ? -44.760 -23.594 9.902   1.00 40.03 ? 229 GLU A OE2 1 
ATOM   1863 N N   . LEU A 1 230 ? -41.309 -22.765 14.376  1.00 20.95 ? 230 LEU A N   1 
ATOM   1864 C CA  . LEU A 1 230 ? -39.959 -22.246 14.492  1.00 19.94 ? 230 LEU A CA  1 
ATOM   1865 C C   . LEU A 1 230 ? -39.054 -23.130 13.652  1.00 19.61 ? 230 LEU A C   1 
ATOM   1866 O O   . LEU A 1 230 ? -39.005 -24.341 13.876  1.00 29.27 ? 230 LEU A O   1 
ATOM   1867 C CB  . LEU A 1 230 ? -39.529 -22.248 15.963  1.00 21.03 ? 230 LEU A CB  1 
ATOM   1868 C CG  . LEU A 1 230 ? -38.341 -21.404 16.395  1.00 24.40 ? 230 LEU A CG  1 
ATOM   1869 C CD1 . LEU A 1 230 ? -38.728 -19.961 16.351  1.00 23.20 ? 230 LEU A CD1 1 
ATOM   1870 C CD2 . LEU A 1 230 ? -37.942 -21.786 17.821  1.00 23.09 ? 230 LEU A CD2 1 
ATOM   1871 N N   . VAL A 1 231 ? -38.354 -22.550 12.673  1.00 14.12 ? 231 VAL A N   1 
ATOM   1872 C CA  . VAL A 1 231 ? -37.456 -23.364 11.868  1.00 11.74 ? 231 VAL A CA  1 
ATOM   1873 C C   . VAL A 1 231 ? -36.077 -23.319 12.504  1.00 18.83 ? 231 VAL A C   1 
ATOM   1874 O O   . VAL A 1 231 ? -35.724 -22.383 13.227  1.00 15.34 ? 231 VAL A O   1 
ATOM   1875 C CB  . VAL A 1 231 ? -37.366 -22.935 10.394  1.00 12.97 ? 231 VAL A CB  1 
ATOM   1876 C CG1 . VAL A 1 231 ? -38.697 -23.211 9.668   1.00 19.36 ? 231 VAL A CG1 1 
ATOM   1877 C CG2 . VAL A 1 231 ? -36.888 -21.502 10.274  1.00 15.51 ? 231 VAL A CG2 1 
ATOM   1878 N N   . GLU A 1 232 ? -35.292 -24.351 12.223  1.00 15.37 ? 232 GLU A N   1 
ATOM   1879 C CA  . GLU A 1 232 ? -33.908 -24.380 12.659  1.00 20.18 ? 232 GLU A CA  1 
ATOM   1880 C C   . GLU A 1 232 ? -33.123 -23.258 11.989  1.00 17.54 ? 232 GLU A C   1 
ATOM   1881 O O   . GLU A 1 232 ? -33.285 -22.995 10.793  1.00 15.39 ? 232 GLU A O   1 
ATOM   1882 C CB  . GLU A 1 232 ? -33.298 -25.726 12.302  1.00 22.77 ? 232 GLU A CB  1 
ATOM   1883 C CG  . GLU A 1 232 ? -32.881 -26.558 13.482  1.00 33.39 ? 232 GLU A CG  1 
ATOM   1884 C CD  . GLU A 1 232 ? -31.828 -27.558 13.070  1.00 42.72 ? 232 GLU A CD  1 
ATOM   1885 O OE1 . GLU A 1 232 ? -31.958 -28.075 11.934  1.00 39.12 ? 232 GLU A OE1 1 
ATOM   1886 O OE2 . GLU A 1 232 ? -30.860 -27.793 13.840  1.00 39.90 ? 232 GLU A OE2 1 
ATOM   1887 N N   . THR A 1 233 ? -32.293 -22.575 12.773  1.00 15.28 ? 233 THR A N   1 
ATOM   1888 C CA  . THR A 1 233 ? -31.388 -21.575 12.229  1.00 12.36 ? 233 THR A CA  1 
ATOM   1889 C C   . THR A 1 233 ? -30.599 -22.172 11.070  1.00 15.31 ? 233 THR A C   1 
ATOM   1890 O O   . THR A 1 233 ? -30.121 -23.304 11.149  1.00 13.01 ? 233 THR A O   1 
ATOM   1891 C CB  . THR A 1 233 ? -30.427 -21.091 13.328  1.00 14.07 ? 233 THR A CB  1 
ATOM   1892 O OG1 . THR A 1 233 ? -31.174 -20.504 14.397  1.00 14.57 ? 233 THR A OG1 1 
ATOM   1893 C CG2 . THR A 1 233 ? -29.470 -20.058 12.791  1.00 12.96 ? 233 THR A CG2 1 
ATOM   1894 N N   . ARG A 1 234 ? -30.464 -21.412 9.992   1.00 11.22 ? 234 ARG A N   1 
ATOM   1895 C CA  . ARG A 1 234 ? -29.917 -21.970 8.773   1.00 12.36 ? 234 ARG A CA  1 
ATOM   1896 C C   . ARG A 1 234 ? -28.885 -21.019 8.190   1.00 11.88 ? 234 ARG A C   1 
ATOM   1897 O O   . ARG A 1 234 ? -28.992 -19.799 8.348   1.00 12.66 ? 234 ARG A O   1 
ATOM   1898 C CB  . ARG A 1 234 ? -31.033 -22.226 7.733   1.00 13.84 ? 234 ARG A CB  1 
ATOM   1899 C CG  . ARG A 1 234 ? -31.746 -20.956 7.290   1.00 12.35 ? 234 ARG A CG  1 
ATOM   1900 C CD  . ARG A 1 234 ? -33.100 -21.247 6.654   1.00 11.92 ? 234 ARG A CD  1 
ATOM   1901 N NE  . ARG A 1 234 ? -33.607 -20.113 5.896   1.00 13.29 ? 234 ARG A NE  1 
ATOM   1902 C CZ  . ARG A 1 234 ? -34.846 -20.049 5.425   1.00 13.72 ? 234 ARG A CZ  1 
ATOM   1903 N NH1 . ARG A 1 234 ? -35.707 -21.023 5.640   1.00 12.87 ? 234 ARG A NH1 1 
ATOM   1904 N NH2 . ARG A 1 234 ? -35.222 -18.990 4.710   1.00 17.26 ? 234 ARG A NH2 1 
ATOM   1905 N N   . PRO A 1 235 ? -27.879 -21.552 7.507   1.00 12.92 ? 235 PRO A N   1 
ATOM   1906 C CA  . PRO A 1 235 ? -26.847 -20.692 6.910   1.00 12.58 ? 235 PRO A CA  1 
ATOM   1907 C C   . PRO A 1 235 ? -27.330 -20.005 5.647   1.00 14.81 ? 235 PRO A C   1 
ATOM   1908 O O   . PRO A 1 235 ? -27.982 -20.612 4.798   1.00 14.80 ? 235 PRO A O   1 
ATOM   1909 C CB  . PRO A 1 235 ? -25.713 -21.677 6.595   1.00 17.65 ? 235 PRO A CB  1 
ATOM   1910 C CG  . PRO A 1 235 ? -26.457 -23.000 6.334   1.00 16.93 ? 235 PRO A CG  1 
ATOM   1911 C CD  . PRO A 1 235 ? -27.605 -22.990 7.329   1.00 13.56 ? 235 PRO A CD  1 
ATOM   1912 N N   . ALA A 1 236 ? -27.002 -18.722 5.515   1.00 12.52 ? 236 ALA A N   1 
ATOM   1913 C CA  . ALA A 1 236 ? -27.310 -18.041 4.264   1.00 13.82 ? 236 ALA A CA  1 
ATOM   1914 C C   . ALA A 1 236 ? -26.359 -18.449 3.148   1.00 20.04 ? 236 ALA A C   1 
ATOM   1915 O O   . ALA A 1 236 ? -26.713 -18.334 1.971   1.00 16.17 ? 236 ALA A O   1 
ATOM   1916 C CB  . ALA A 1 236 ? -27.270 -16.528 4.460   1.00 12.12 ? 236 ALA A CB  1 
ATOM   1917 N N   . GLY A 1 237 ? -25.176 -18.958 3.494   1.00 15.40 ? 237 GLY A N   1 
ATOM   1918 C CA  . GLY A 1 237 ? -24.156 -19.289 2.517   1.00 18.52 ? 237 GLY A CA  1 
ATOM   1919 C C   . GLY A 1 237 ? -23.012 -18.297 2.429   1.00 20.15 ? 237 GLY A C   1 
ATOM   1920 O O   . GLY A 1 237 ? -21.983 -18.621 1.824   1.00 25.14 ? 237 GLY A O   1 
ATOM   1921 N N   . ASP A 1 238 ? -23.163 -17.103 3.005   1.00 18.49 ? 238 ASP A N   1 
ATOM   1922 C CA  . ASP A 1 238 ? -22.154 -16.052 2.974   1.00 23.77 ? 238 ASP A CA  1 
ATOM   1923 C C   . ASP A 1 238 ? -21.510 -15.849 4.336   1.00 20.65 ? 238 ASP A C   1 
ATOM   1924 O O   . ASP A 1 238 ? -20.965 -14.774 4.595   1.00 18.54 ? 238 ASP A O   1 
ATOM   1925 C CB  . ASP A 1 238 ? -22.753 -14.720 2.510   1.00 18.89 ? 238 ASP A CB  1 
ATOM   1926 C CG  . ASP A 1 238 ? -23.966 -14.295 3.351   1.00 22.43 ? 238 ASP A CG  1 
ATOM   1927 O OD1 . ASP A 1 238 ? -24.208 -14.896 4.418   1.00 20.17 ? 238 ASP A OD1 1 
ATOM   1928 O OD2 . ASP A 1 238 ? -24.675 -13.344 2.959   1.00 23.70 ? 238 ASP A OD2 1 
ATOM   1929 N N   . GLY A 1 239 ? -21.626 -16.832 5.231   1.00 17.09 ? 239 GLY A N   1 
ATOM   1930 C CA  . GLY A 1 239 ? -21.147 -16.703 6.589   1.00 21.36 ? 239 GLY A CA  1 
ATOM   1931 C C   . GLY A 1 239 ? -22.143 -16.144 7.597   1.00 19.19 ? 239 GLY A C   1 
ATOM   1932 O O   . GLY A 1 239 ? -21.815 -16.088 8.784   1.00 21.04 ? 239 GLY A O   1 
ATOM   1933 N N   . THR A 1 240 ? -23.315 -15.678 7.169   1.00 17.07 ? 240 THR A N   1 
ATOM   1934 C CA  . THR A 1 240 ? -24.348 -15.243 8.101   1.00 15.74 ? 240 THR A CA  1 
ATOM   1935 C C   . THR A 1 240 ? -25.471 -16.279 8.176   1.00 16.10 ? 240 THR A C   1 
ATOM   1936 O O   . THR A 1 240 ? -25.482 -17.274 7.443   1.00 13.77 ? 240 THR A O   1 
ATOM   1937 C CB  . THR A 1 240 ? -24.912 -13.876 7.709   1.00 20.95 ? 240 THR A CB  1 
ATOM   1938 O OG1 . THR A 1 240 ? -25.668 -13.998 6.495   1.00 16.35 ? 240 THR A OG1 1 
ATOM   1939 C CG2 . THR A 1 240 ? -23.799 -12.833 7.566   1.00 20.49 ? 240 THR A CG2 1 
ATOM   1940 N N   . PHE A 1 241 ? -26.432 -16.034 9.077   1.00 11.58 ? 241 PHE A N   1 
ATOM   1941 C CA  . PHE A 1 241 ? -27.471 -17.010 9.374   1.00 15.38 ? 241 PHE A CA  1 
ATOM   1942 C C   . PHE A 1 241 ? -28.873 -16.413 9.240   1.00 14.35 ? 241 PHE A C   1 
ATOM   1943 O O   . PHE A 1 241 ? -29.061 -15.193 9.210   1.00 14.24 ? 241 PHE A O   1 
ATOM   1944 C CB  . PHE A 1 241 ? -27.246 -17.602 10.768  1.00 13.18 ? 241 PHE A CB  1 
ATOM   1945 C CG  . PHE A 1 241 ? -26.001 -18.431 10.843  1.00 12.46 ? 241 PHE A CG  1 
ATOM   1946 C CD1 . PHE A 1 241 ? -24.780 -17.845 11.143  1.00 15.42 ? 241 PHE A CD1 1 
ATOM   1947 C CD2 . PHE A 1 241 ? -26.034 -19.783 10.523  1.00 14.58 ? 241 PHE A CD2 1 
ATOM   1948 C CE1 . PHE A 1 241 ? -23.616 -18.610 11.163  1.00 16.29 ? 241 PHE A CE1 1 
ATOM   1949 C CE2 . PHE A 1 241 ? -24.875 -20.551 10.540  1.00 15.07 ? 241 PHE A CE2 1 
ATOM   1950 C CZ  . PHE A 1 241 ? -23.667 -19.960 10.865  1.00 15.13 ? 241 PHE A CZ  1 
ATOM   1951 N N   . GLN A 1 242 ? -29.861 -17.302 9.128   1.00 12.80 ? 242 GLN A N   1 
ATOM   1952 C CA  . GLN A 1 242 ? -31.262 -16.914 8.988   1.00 11.82 ? 242 GLN A CA  1 
ATOM   1953 C C   . GLN A 1 242 ? -32.144 -17.727 9.921   1.00 12.03 ? 242 GLN A C   1 
ATOM   1954 O O   . GLN A 1 242 ? -31.844 -18.876 10.262  1.00 11.82 ? 242 GLN A O   1 
ATOM   1955 C CB  . GLN A 1 242 ? -31.780 -17.092 7.564   1.00 13.37 ? 242 GLN A CB  1 
ATOM   1956 C CG  . GLN A 1 242 ? -30.791 -16.716 6.485   1.00 14.46 ? 242 GLN A CG  1 
ATOM   1957 C CD  . GLN A 1 242 ? -31.378 -16.898 5.090   1.00 15.18 ? 242 GLN A CD  1 
ATOM   1958 O OE1 . GLN A 1 242 ? -32.312 -17.677 4.895   1.00 15.71 ? 242 GLN A OE1 1 
ATOM   1959 N NE2 . GLN A 1 242 ? -30.812 -16.204 4.113   1.00 15.74 ? 242 GLN A NE2 1 
ATOM   1960 N N   . LYS A 1 243 ? -33.273 -17.131 10.291  1.00 12.31 ? 243 LYS A N   1 
ATOM   1961 C CA  . LYS A 1 243 ? -34.254 -17.846 11.081  1.00 10.78 ? 243 LYS A CA  1 
ATOM   1962 C C   . LYS A 1 243 ? -35.602 -17.160 10.927  1.00 11.83 ? 243 LYS A C   1 
ATOM   1963 O O   . LYS A 1 243 ? -35.668 -15.944 10.737  1.00 10.61 ? 243 LYS A O   1 
ATOM   1964 C CB  . LYS A 1 243 ? -33.848 -17.891 12.553  1.00 10.68 ? 243 LYS A CB  1 
ATOM   1965 C CG  . LYS A 1 243 ? -34.491 -19.032 13.331  1.00 13.05 ? 243 LYS A CG  1 
ATOM   1966 C CD  . LYS A 1 243 ? -34.222 -18.901 14.830  1.00 14.90 ? 243 LYS A CD  1 
ATOM   1967 C CE  . LYS A 1 243 ? -34.847 -20.070 15.586  1.00 19.05 ? 243 LYS A CE  1 
ATOM   1968 N NZ  . LYS A 1 243 ? -34.143 -21.362 15.263  1.00 16.73 ? 243 LYS A NZ  1 
ATOM   1969 N N   . TRP A 1 244 ? -36.672 -17.935 11.058  1.00 9.62  ? 244 TRP A N   1 
ATOM   1970 C CA  . TRP A 1 244 ? -37.971 -17.297 11.177  1.00 12.96 ? 244 TRP A CA  1 
ATOM   1971 C C   . TRP A 1 244 ? -38.867 -18.056 12.145  1.00 13.75 ? 244 TRP A C   1 
ATOM   1972 O O   . TRP A 1 244 ? -38.625 -19.218 12.484  1.00 13.27 ? 244 TRP A O   1 
ATOM   1973 C CB  . TRP A 1 244 ? -38.647 -17.128 9.818   1.00 13.17 ? 244 TRP A CB  1 
ATOM   1974 C CG  . TRP A 1 244 ? -38.918 -18.354 8.984   1.00 15.50 ? 244 TRP A CG  1 
ATOM   1975 C CD1 . TRP A 1 244 ? -38.224 -18.753 7.869   1.00 15.58 ? 244 TRP A CD1 1 
ATOM   1976 C CD2 . TRP A 1 244 ? -39.986 -19.294 9.149   1.00 13.51 ? 244 TRP A CD2 1 
ATOM   1977 N NE1 . TRP A 1 244 ? -38.786 -19.885 7.348   1.00 17.31 ? 244 TRP A NE1 1 
ATOM   1978 C CE2 . TRP A 1 244 ? -39.874 -20.237 8.108   1.00 17.28 ? 244 TRP A CE2 1 
ATOM   1979 C CE3 . TRP A 1 244 ? -41.028 -19.435 10.081  1.00 14.21 ? 244 TRP A CE3 1 
ATOM   1980 C CZ2 . TRP A 1 244 ? -40.768 -21.298 7.960   1.00 18.70 ? 244 TRP A CZ2 1 
ATOM   1981 C CZ3 . TRP A 1 244 ? -41.916 -20.489 9.931   1.00 17.64 ? 244 TRP A CZ3 1 
ATOM   1982 C CH2 . TRP A 1 244 ? -41.774 -21.413 8.885   1.00 19.61 ? 244 TRP A CH2 1 
ATOM   1983 N N   . ALA A 1 245 ? -39.893 -17.350 12.618  1.00 13.62 ? 245 ALA A N   1 
ATOM   1984 C CA  . ALA A 1 245 ? -40.887 -17.883 13.543  1.00 12.96 ? 245 ALA A CA  1 
ATOM   1985 C C   . ALA A 1 245 ? -42.242 -17.407 13.060  1.00 13.04 ? 245 ALA A C   1 
ATOM   1986 O O   . ALA A 1 245 ? -42.398 -16.224 12.741  1.00 12.31 ? 245 ALA A O   1 
ATOM   1987 C CB  . ALA A 1 245 ? -40.648 -17.396 14.973  1.00 13.42 ? 245 ALA A CB  1 
ATOM   1988 N N   . ALA A 1 246 ? -43.211 -18.313 13.001  1.00 12.86 ? 246 ALA A N   1 
ATOM   1989 C CA  . ALA A 1 246 ? -44.522 -17.975 12.470  1.00 16.25 ? 246 ALA A CA  1 
ATOM   1990 C C   . ALA A 1 246 ? -45.610 -18.364 13.458  1.00 17.93 ? 246 ALA A C   1 
ATOM   1991 O O   . ALA A 1 246 ? -45.470 -19.308 14.241  1.00 15.66 ? 246 ALA A O   1 
ATOM   1992 C CB  . ALA A 1 246 ? -44.803 -18.657 11.117  1.00 15.60 ? 246 ALA A CB  1 
ATOM   1993 N N   . VAL A 1 247 ? -46.717 -17.649 13.374  1.00 14.54 ? 247 VAL A N   1 
ATOM   1994 C CA  . VAL A 1 247 ? -47.896 -17.972 14.157  1.00 14.69 ? 247 VAL A CA  1 
ATOM   1995 C C   . VAL A 1 247 ? -49.130 -17.719 13.294  1.00 16.40 ? 247 VAL A C   1 
ATOM   1996 O O   . VAL A 1 247 ? -49.125 -16.851 12.416  1.00 12.73 ? 247 VAL A O   1 
ATOM   1997 C CB  . VAL A 1 247 ? -47.874 -17.161 15.460  1.00 15.28 ? 247 VAL A CB  1 
ATOM   1998 C CG1 . VAL A 1 247 ? -48.094 -15.680 15.175  1.00 14.42 ? 247 VAL A CG1 1 
ATOM   1999 C CG2 . VAL A 1 247 ? -48.920 -17.709 16.431  1.00 24.00 ? 247 VAL A CG2 1 
ATOM   2000 N N   . VAL A 1 248 ? -50.161 -18.537 13.497  1.00 17.19 ? 248 VAL A N   1 
ATOM   2001 C CA  . VAL A 1 248 ? -51.440 -18.395 12.802  1.00 15.74 ? 248 VAL A CA  1 
ATOM   2002 C C   . VAL A 1 248 ? -52.398 -17.683 13.744  1.00 17.48 ? 248 VAL A C   1 
ATOM   2003 O O   . VAL A 1 248 ? -52.619 -18.142 14.868  1.00 17.64 ? 248 VAL A O   1 
ATOM   2004 C CB  . VAL A 1 248 ? -51.998 -19.759 12.359  1.00 20.03 ? 248 VAL A CB  1 
ATOM   2005 C CG1 . VAL A 1 248 ? -53.413 -19.609 11.790  1.00 19.70 ? 248 VAL A CG1 1 
ATOM   2006 C CG2 . VAL A 1 248 ? -51.051 -20.412 11.334  1.00 20.13 ? 248 VAL A CG2 1 
ATOM   2007 N N   . VAL A 1 249 ? -52.945 -16.553 13.304  1.00 16.56 ? 249 VAL A N   1 
ATOM   2008 C CA  . VAL A 1 249 ? -53.655 -15.655 14.207  1.00 15.17 ? 249 VAL A CA  1 
ATOM   2009 C C   . VAL A 1 249 ? -55.057 -15.437 13.653  1.00 21.08 ? 249 VAL A C   1 
ATOM   2010 O O   . VAL A 1 249 ? -55.270 -15.546 12.434  1.00 16.08 ? 249 VAL A O   1 
ATOM   2011 C CB  . VAL A 1 249 ? -52.920 -14.315 14.360  1.00 18.29 ? 249 VAL A CB  1 
ATOM   2012 C CG1 . VAL A 1 249 ? -51.489 -14.540 14.908  1.00 17.93 ? 249 VAL A CG1 1 
ATOM   2013 C CG2 . VAL A 1 249 ? -52.893 -13.546 13.071  1.00 20.30 ? 249 VAL A CG2 1 
ATOM   2014 N N   . PRO A 1 250 ? -56.040 -15.136 14.496  1.00 19.62 ? 250 PRO A N   1 
ATOM   2015 C CA  . PRO A 1 250 ? -57.376 -14.825 13.975  1.00 21.91 ? 250 PRO A CA  1 
ATOM   2016 C C   . PRO A 1 250 ? -57.325 -13.535 13.175  1.00 23.05 ? 250 PRO A C   1 
ATOM   2017 O O   . PRO A 1 250 ? -56.668 -12.573 13.577  1.00 20.37 ? 250 PRO A O   1 
ATOM   2018 C CB  . PRO A 1 250 ? -58.223 -14.657 15.243  1.00 23.81 ? 250 PRO A CB  1 
ATOM   2019 C CG  . PRO A 1 250 ? -57.459 -15.372 16.329  1.00 20.79 ? 250 PRO A CG  1 
ATOM   2020 C CD  . PRO A 1 250 ? -56.008 -15.192 15.970  1.00 19.28 ? 250 PRO A CD  1 
ATOM   2021 N N   . SER A 1 251 ? -58.025 -13.504 12.037  1.00 24.38 ? 251 SER A N   1 
ATOM   2022 C CA  . SER A 1 251 ? -57.971 -12.299 11.218  1.00 24.99 ? 251 SER A CA  1 
ATOM   2023 C C   . SER A 1 251 ? -58.534 -11.117 12.000  1.00 22.13 ? 251 SER A C   1 
ATOM   2024 O O   . SER A 1 251 ? -59.479 -11.257 12.780  1.00 23.24 ? 251 SER A O   1 
ATOM   2025 C CB  . SER A 1 251 ? -58.724 -12.501 9.899   1.00 32.84 ? 251 SER A CB  1 
ATOM   2026 O OG  . SER A 1 251 ? -59.836 -13.347 10.082  1.00 32.89 ? 251 SER A OG  1 
ATOM   2027 N N   . GLY A 1 252 ? -57.908 -9.958  11.833  1.00 21.36 ? 252 GLY A N   1 
ATOM   2028 C CA  . GLY A 1 252 ? -58.244 -8.789  12.613  1.00 24.54 ? 252 GLY A CA  1 
ATOM   2029 C C   . GLY A 1 252 ? -57.606 -8.697  13.988  1.00 22.82 ? 252 GLY A C   1 
ATOM   2030 O O   . GLY A 1 252 ? -57.772 -7.672  14.655  1.00 26.94 ? 252 GLY A O   1 
ATOM   2031 N N   . GLU A 1 253 ? -56.891 -9.724  14.453  1.00 19.68 ? 253 GLU A N   1 
ATOM   2032 C CA  . GLU A 1 253 ? -56.241 -9.651  15.759  1.00 17.39 ? 253 GLU A CA  1 
ATOM   2033 C C   . GLU A 1 253 ? -54.724 -9.617  15.677  1.00 21.56 ? 253 GLU A C   1 
ATOM   2034 O O   . GLU A 1 253 ? -54.056 -9.794  16.700  1.00 18.89 ? 253 GLU A O   1 
ATOM   2035 C CB  . GLU A 1 253 ? -56.697 -10.788 16.671  1.00 18.59 ? 253 GLU A CB  1 
ATOM   2036 C CG  . GLU A 1 253 ? -58.208 -10.928 16.767  1.00 27.06 ? 253 GLU A CG  1 
ATOM   2037 C CD  . GLU A 1 253 ? -58.783 -9.741  17.554  1.00 23.81 ? 253 GLU A CD  1 
ATOM   2038 O OE1 . GLU A 1 253 ? -59.952 -9.352  17.329  1.00 23.56 ? 253 GLU A OE1 1 
ATOM   2039 O OE2 . GLU A 1 253 ? -58.028 -9.144  18.351  1.00 22.08 ? 253 GLU A OE2 1 
ATOM   2040 N N   . GLU A 1 254 ? -54.182 -9.331  14.492  1.00 18.67 ? 254 GLU A N   1 
ATOM   2041 C CA  . GLU A 1 254 ? -52.739 -9.238  14.304  1.00 19.46 ? 254 GLU A CA  1 
ATOM   2042 C C   . GLU A 1 254 ? -52.091 -8.325  15.335  1.00 19.33 ? 254 GLU A C   1 
ATOM   2043 O O   . GLU A 1 254 ? -50.987 -8.600  15.814  1.00 22.14 ? 254 GLU A O   1 
ATOM   2044 C CB  . GLU A 1 254 ? -52.450 -8.720  12.895  1.00 20.43 ? 254 GLU A CB  1 
ATOM   2045 C CG  . GLU A 1 254 ? -52.631 -9.760  11.813  1.00 22.41 ? 254 GLU A CG  1 
ATOM   2046 C CD  . GLU A 1 254 ? -54.067 -9.861  11.308  1.00 21.58 ? 254 GLU A CD  1 
ATOM   2047 O OE1 . GLU A 1 254 ? -54.988 -9.237  11.902  1.00 24.44 ? 254 GLU A OE1 1 
ATOM   2048 O OE2 . GLU A 1 254 ? -54.275 -10.573 10.305  1.00 20.84 ? 254 GLU A OE2 1 
ATOM   2049 N N   . GLN A 1 255 ? -52.765 -7.236  15.701  1.00 20.57 ? 255 GLN A N   1 
ATOM   2050 C CA  . GLN A 1 255 ? -52.100 -6.258  16.539  1.00 19.59 ? 255 GLN A CA  1 
ATOM   2051 C C   . GLN A 1 255 ? -51.898 -6.720  17.982  1.00 22.66 ? 255 GLN A C   1 
ATOM   2052 O O   . GLN A 1 255 ? -51.154 -6.057  18.715  1.00 22.27 ? 255 GLN A O   1 
ATOM   2053 C CB  . GLN A 1 255 ? -52.825 -4.908  16.486  1.00 23.24 ? 255 GLN A CB  1 
ATOM   2054 C CG  . GLN A 1 255 ? -54.096 -4.694  17.349  1.00 33.40 ? 255 GLN A CG  1 
ATOM   2055 C CD  . GLN A 1 255 ? -55.228 -5.719  17.145  1.00 36.83 ? 255 GLN A CD  1 
ATOM   2056 O OE1 . GLN A 1 255 ? -55.444 -6.234  16.035  1.00 35.53 ? 255 GLN A OE1 1 
ATOM   2057 N NE2 . GLN A 1 255 ? -55.979 -5.987  18.218  1.00 40.97 ? 255 GLN A NE2 1 
ATOM   2058 N N   . ARG A 1 256 ? -52.474 -7.846  18.408  1.00 16.49 ? 256 ARG A N   1 
ATOM   2059 C CA  . ARG A 1 256 ? -52.136 -8.306  19.750  1.00 18.81 ? 256 ARG A CA  1 
ATOM   2060 C C   . ARG A 1 256 ? -50.850 -9.116  19.797  1.00 21.99 ? 256 ARG A C   1 
ATOM   2061 O O   . ARG A 1 256 ? -50.375 -9.421  20.897  1.00 19.89 ? 256 ARG A O   1 
ATOM   2062 C CB  . ARG A 1 256 ? -53.262 -9.134  20.394  1.00 21.51 ? 256 ARG A CB  1 
ATOM   2063 C CG  . ARG A 1 256 ? -54.687 -8.661  20.125  1.00 20.22 ? 256 ARG A CG  1 
ATOM   2064 C CD  . ARG A 1 256 ? -55.729 -9.742  20.446  1.00 21.53 ? 256 ARG A CD  1 
ATOM   2065 N NE  . ARG A 1 256 ? -57.050 -9.144  20.652  1.00 19.36 ? 256 ARG A NE  1 
ATOM   2066 C CZ  . ARG A 1 256 ? -57.487 -8.625  21.794  1.00 23.13 ? 256 ARG A CZ  1 
ATOM   2067 N NH1 . ARG A 1 256 ? -56.697 -8.520  22.852  1.00 22.08 ? 256 ARG A NH1 1 
ATOM   2068 N NH2 . ARG A 1 256 ? -58.741 -8.163  21.862  1.00 19.62 ? 256 ARG A NH2 1 
ATOM   2069 N N   . TYR A 1 257 ? -50.255 -9.435  18.648  1.00 18.89 ? 257 TYR A N   1 
ATOM   2070 C CA  . TYR A 1 257 ? -49.082 -10.297 18.605  1.00 17.72 ? 257 TYR A CA  1 
ATOM   2071 C C   . TYR A 1 257 ? -47.814 -9.479  18.407  1.00 18.74 ? 257 TYR A C   1 
ATOM   2072 O O   . TYR A 1 257 ? -47.768 -8.569  17.570  1.00 17.76 ? 257 TYR A O   1 
ATOM   2073 C CB  . TYR A 1 257 ? -49.195 -11.330 17.484  1.00 16.95 ? 257 TYR A CB  1 
ATOM   2074 C CG  . TYR A 1 257 ? -50.287 -12.340 17.705  1.00 16.67 ? 257 TYR A CG  1 
ATOM   2075 C CD1 . TYR A 1 257 ? -51.624 -11.999 17.506  1.00 20.71 ? 257 TYR A CD1 1 
ATOM   2076 C CD2 . TYR A 1 257 ? -49.998 -13.619 18.154  1.00 17.37 ? 257 TYR A CD2 1 
ATOM   2077 C CE1 . TYR A 1 257 ? -52.626 -12.915 17.718  1.00 18.10 ? 257 TYR A CE1 1 
ATOM   2078 C CE2 . TYR A 1 257 ? -51.002 -14.543 18.373  1.00 19.53 ? 257 TYR A CE2 1 
ATOM   2079 C CZ  . TYR A 1 257 ? -52.314 -14.184 18.146  1.00 21.02 ? 257 TYR A CZ  1 
ATOM   2080 O OH  . TYR A 1 257 ? -53.328 -15.094 18.347  1.00 26.99 ? 257 TYR A OH  1 
ATOM   2081 N N   . THR A 1 258 ? -46.771 -9.836  19.158  1.00 16.86 ? 258 THR A N   1 
ATOM   2082 C CA  . THR A 1 258 ? -45.469 -9.209  19.017  1.00 15.51 ? 258 THR A CA  1 
ATOM   2083 C C   . THR A 1 258 ? -44.399 -10.279 18.884  1.00 16.78 ? 258 THR A C   1 
ATOM   2084 O O   . THR A 1 258 ? -44.432 -11.304 19.574  1.00 15.01 ? 258 THR A O   1 
ATOM   2085 C CB  . THR A 1 258 ? -45.131 -8.342  20.200  1.00 18.87 ? 258 THR A CB  1 
ATOM   2086 O OG1 . THR A 1 258 ? -45.398 -9.093  21.389  1.00 20.40 ? 258 THR A OG1 1 
ATOM   2087 C CG2 . THR A 1 258 ? -45.968 -7.089  20.179  1.00 20.59 ? 258 THR A CG2 1 
ATOM   2088 N N   . CYS A 1 259 ? -43.442 -10.018 18.010  1.00 15.51 ? 259 CYS A N   1 
ATOM   2089 C CA  . CYS A 1 259 ? -42.292 -10.889 17.844  1.00 16.53 ? 259 CYS A CA  1 
ATOM   2090 C C   . CYS A 1 259 ? -41.090 -10.252 18.531  1.00 14.64 ? 259 CYS A C   1 
ATOM   2091 O O   . CYS A 1 259 ? -40.808 -9.073  18.319  1.00 17.61 ? 259 CYS A O   1 
ATOM   2092 C CB  . CYS A 1 259 ? -42.012 -11.120 16.364  1.00 18.42 ? 259 CYS A CB  1 
ATOM   2093 S SG  . CYS A 1 259 ? -40.541 -12.105 16.112  1.00 25.10 ? 259 CYS A SG  1 
ATOM   2094 N N   . HIS A 1 260 ? -40.402 -11.020 19.364  1.00 16.00 ? 260 HIS A N   1 
ATOM   2095 C CA  . HIS A 1 260 ? -39.268 -10.518 20.141  1.00 15.90 ? 260 HIS A CA  1 
ATOM   2096 C C   . HIS A 1 260 ? -37.992 -11.213 19.690  1.00 18.03 ? 260 HIS A C   1 
ATOM   2097 O O   . HIS A 1 260 ? -37.933 -12.445 19.661  1.00 17.20 ? 260 HIS A O   1 
ATOM   2098 C CB  . HIS A 1 260 ? -39.501 -10.713 21.642  1.00 19.25 ? 260 HIS A CB  1 
ATOM   2099 C CG  . HIS A 1 260 ? -40.807 -10.149 22.118  1.00 20.79 ? 260 HIS A CG  1 
ATOM   2100 N ND1 . HIS A 1 260 ? -40.880 -9.033  22.925  1.00 26.19 ? 260 HIS A ND1 1 
ATOM   2101 C CD2 . HIS A 1 260 ? -42.090 -10.505 21.852  1.00 22.96 ? 260 HIS A CD2 1 
ATOM   2102 C CE1 . HIS A 1 260 ? -42.149 -8.737  23.154  1.00 26.61 ? 260 HIS A CE1 1 
ATOM   2103 N NE2 . HIS A 1 260 ? -42.904 -9.615  22.516  1.00 21.91 ? 260 HIS A NE2 1 
ATOM   2104 N N   . VAL A 1 261 ? -36.985 -10.418 19.337  1.00 15.69 ? 261 VAL A N   1 
ATOM   2105 C CA  . VAL A 1 261 ? -35.736 -10.905 18.757  1.00 14.97 ? 261 VAL A CA  1 
ATOM   2106 C C   . VAL A 1 261 ? -34.604 -10.544 19.715  1.00 16.71 ? 261 VAL A C   1 
ATOM   2107 O O   . VAL A 1 261 ? -34.417 -9.365  20.029  1.00 17.68 ? 261 VAL A O   1 
ATOM   2108 C CB  . VAL A 1 261 ? -35.479 -10.286 17.379  1.00 15.69 ? 261 VAL A CB  1 
ATOM   2109 C CG1 . VAL A 1 261 ? -34.260 -10.947 16.702  1.00 16.26 ? 261 VAL A CG1 1 
ATOM   2110 C CG2 . VAL A 1 261 ? -36.742 -10.370 16.500  1.00 15.06 ? 261 VAL A CG2 1 
ATOM   2111 N N   . GLN A 1 262 ? -33.853 -11.545 20.170  1.00 14.28 ? 262 GLN A N   1 
ATOM   2112 C CA  . GLN A 1 262 ? -32.647 -11.311 20.967  1.00 13.80 ? 262 GLN A CA  1 
ATOM   2113 C C   . GLN A 1 262 ? -31.432 -11.896 20.271  1.00 16.54 ? 262 GLN A C   1 
ATOM   2114 O O   . GLN A 1 262 ? -31.461 -13.047 19.825  1.00 15.27 ? 262 GLN A O   1 
ATOM   2115 C CB  . GLN A 1 262 ? -32.753 -11.898 22.367  1.00 21.01 ? 262 GLN A CB  1 
ATOM   2116 C CG  . GLN A 1 262 ? -34.140 -11.874 22.937  1.00 28.73 ? 262 GLN A CG  1 
ATOM   2117 C CD  . GLN A 1 262 ? -34.196 -12.547 24.279  1.00 33.22 ? 262 GLN A CD  1 
ATOM   2118 O OE1 . GLN A 1 262 ? -34.838 -13.582 24.440  1.00 38.34 ? 262 GLN A OE1 1 
ATOM   2119 N NE2 . GLN A 1 262 ? -33.521 -11.963 25.258  1.00 35.71 ? 262 GLN A NE2 1 
ATOM   2120 N N   . HIS A 1 263 ? -30.368 -11.105 20.211  1.00 15.01 ? 263 HIS A N   1 
ATOM   2121 C CA  . HIS A 1 263 ? -29.128 -11.465 19.541  1.00 17.69 ? 263 HIS A CA  1 
ATOM   2122 C C   . HIS A 1 263 ? -28.022 -10.599 20.113  1.00 20.33 ? 263 HIS A C   1 
ATOM   2123 O O   . HIS A 1 263 ? -28.261 -9.445  20.476  1.00 21.41 ? 263 HIS A O   1 
ATOM   2124 C CB  . HIS A 1 263 ? -29.220 -11.244 18.033  1.00 15.59 ? 263 HIS A CB  1 
ATOM   2125 C CG  . HIS A 1 263 ? -28.042 -11.773 17.284  1.00 17.17 ? 263 HIS A CG  1 
ATOM   2126 N ND1 . HIS A 1 263 ? -26.983 -10.976 16.915  1.00 16.25 ? 263 HIS A ND1 1 
ATOM   2127 C CD2 . HIS A 1 263 ? -27.755 -13.017 16.839  1.00 17.57 ? 263 HIS A CD2 1 
ATOM   2128 C CE1 . HIS A 1 263 ? -26.093 -11.705 16.264  1.00 17.56 ? 263 HIS A CE1 1 
ATOM   2129 N NE2 . HIS A 1 263 ? -26.540 -12.946 16.199  1.00 14.82 ? 263 HIS A NE2 1 
ATOM   2130 N N   . GLU A 1 264 ? -26.798 -11.143 20.139  1.00 24.34 ? 264 GLU A N   1 
ATOM   2131 C CA  . GLU A 1 264 ? -25.701 -10.443 20.810  1.00 22.68 ? 264 GLU A CA  1 
ATOM   2132 C C   . GLU A 1 264 ? -25.368 -9.125  20.131  1.00 26.95 ? 264 GLU A C   1 
ATOM   2133 O O   . GLU A 1 264 ? -24.780 -8.242  20.761  1.00 27.43 ? 264 GLU A O   1 
ATOM   2134 C CB  . GLU A 1 264 ? -24.448 -11.310 20.845  1.00 29.67 ? 264 GLU A CB  1 
ATOM   2135 C CG  . GLU A 1 264 ? -24.759 -12.775 20.711  1.00 38.87 ? 264 GLU A CG  1 
ATOM   2136 C CD  . GLU A 1 264 ? -23.521 -13.649 20.709  1.00 41.19 ? 264 GLU A CD  1 
ATOM   2137 O OE1 . GLU A 1 264 ? -22.394 -13.117 20.503  1.00 35.87 ? 264 GLU A OE1 1 
ATOM   2138 O OE2 . GLU A 1 264 ? -23.714 -14.886 20.841  1.00 35.66 ? 264 GLU A OE2 1 
ATOM   2139 N N   . GLY A 1 265 ? -25.713 -8.980  18.847  1.00 25.74 ? 265 GLY A N   1 
ATOM   2140 C CA  . GLY A 1 265 ? -25.460 -7.761  18.105  1.00 25.98 ? 265 GLY A CA  1 
ATOM   2141 C C   . GLY A 1 265 ? -26.481 -6.672  18.298  1.00 29.04 ? 265 GLY A C   1 
ATOM   2142 O O   . GLY A 1 265 ? -26.340 -5.573  17.754  1.00 31.02 ? 265 GLY A O   1 
ATOM   2143 N N   . LEU A 1 266 ? -27.519 -6.940  19.075  1.00 26.94 ? 266 LEU A N   1 
ATOM   2144 C CA  . LEU A 1 266 ? -28.509 -5.925  19.358  1.00 35.10 ? 266 LEU A CA  1 
ATOM   2145 C C   . LEU A 1 266 ? -28.212 -5.324  20.718  1.00 34.78 ? 266 LEU A C   1 
ATOM   2146 O O   . LEU A 1 266 ? -28.274 -6.044  21.728  1.00 37.67 ? 266 LEU A O   1 
ATOM   2147 C CB  . LEU A 1 266 ? -29.914 -6.514  19.334  1.00 28.75 ? 266 LEU A CB  1 
ATOM   2148 C CG  . LEU A 1 266 ? -30.344 -7.094  17.992  1.00 25.34 ? 266 LEU A CG  1 
ATOM   2149 C CD1 . LEU A 1 266 ? -31.568 -8.000  18.170  1.00 22.93 ? 266 LEU A CD1 1 
ATOM   2150 C CD2 . LEU A 1 266 ? -30.599 -5.985  16.982  1.00 27.59 ? 266 LEU A CD2 1 
ATOM   2151 N N   . PRO A 1 267 ? -27.896 -4.033  20.796  1.00 37.15 ? 267 PRO A N   1 
ATOM   2152 C CA  . PRO A 1 267 ? -27.880 -3.374  22.109  1.00 38.07 ? 267 PRO A CA  1 
ATOM   2153 C C   . PRO A 1 267 ? -29.179 -3.591  22.862  1.00 39.75 ? 267 PRO A C   1 
ATOM   2154 O O   . PRO A 1 267 ? -29.172 -3.794  24.081  1.00 38.70 ? 267 PRO A O   1 
ATOM   2155 C CB  . PRO A 1 267 ? -27.666 -1.899  21.751  1.00 43.91 ? 267 PRO A CB  1 
ATOM   2156 C CG  . PRO A 1 267 ? -28.224 -1.759  20.352  1.00 40.95 ? 267 PRO A CG  1 
ATOM   2157 C CD  . PRO A 1 267 ? -27.935 -3.073  19.679  1.00 41.24 ? 267 PRO A CD  1 
ATOM   2158 N N   . LYS A 1 268 ? -30.296 -3.616  22.130  1.00 37.91 ? 268 LYS A N   1 
ATOM   2159 C CA  . LYS A 1 268 ? -31.645 -3.658  22.661  1.00 41.05 ? 268 LYS A CA  1 
ATOM   2160 C C   . LYS A 1 268 ? -32.342 -4.844  22.010  1.00 33.86 ? 268 LYS A C   1 
ATOM   2161 O O   . LYS A 1 268 ? -32.280 -4.988  20.777  1.00 34.58 ? 268 LYS A O   1 
ATOM   2162 C CB  . LYS A 1 268 ? -32.403 -2.371  22.289  1.00 45.01 ? 268 LYS A CB  1 
ATOM   2163 C CG  . LYS A 1 268 ? -32.925 -1.520  23.416  1.00 48.07 ? 268 LYS A CG  1 
ATOM   2164 C CD  . LYS A 1 268 ? -31.847 -1.297  24.451  1.00 51.10 ? 268 LYS A CD  1 
ATOM   2165 C CE  . LYS A 1 268 ? -32.145 -0.030  25.247  1.00 60.94 ? 268 LYS A CE  1 
ATOM   2166 N NZ  . LYS A 1 268 ? -31.133 0.219   26.311  1.00 59.43 ? 268 LYS A NZ  1 
ATOM   2167 N N   . PRO A 1 269 ? -33.027 -5.698  22.763  1.00 30.70 ? 269 PRO A N   1 
ATOM   2168 C CA  . PRO A 1 269 ? -33.944 -6.647  22.122  1.00 29.50 ? 269 PRO A CA  1 
ATOM   2169 C C   . PRO A 1 269 ? -34.982 -5.893  21.297  1.00 29.85 ? 269 PRO A C   1 
ATOM   2170 O O   . PRO A 1 269 ? -35.409 -4.797  21.661  1.00 32.18 ? 269 PRO A O   1 
ATOM   2171 C CB  . PRO A 1 269 ? -34.580 -7.383  23.304  1.00 30.30 ? 269 PRO A CB  1 
ATOM   2172 C CG  . PRO A 1 269 ? -33.565 -7.253  24.410  1.00 30.84 ? 269 PRO A CG  1 
ATOM   2173 C CD  . PRO A 1 269 ? -32.928 -5.905  24.217  1.00 31.70 ? 269 PRO A CD  1 
ATOM   2174 N N   . LEU A 1 270 ? -35.357 -6.463  20.159  1.00 26.23 ? 270 LEU A N   1 
ATOM   2175 C CA  . LEU A 1 270 ? -36.356 -5.840  19.303  1.00 28.66 ? 270 LEU A CA  1 
ATOM   2176 C C   . LEU A 1 270 ? -37.729 -6.422  19.569  1.00 26.78 ? 270 LEU A C   1 
ATOM   2177 O O   . LEU A 1 270 ? -37.871 -7.608  19.873  1.00 25.59 ? 270 LEU A O   1 
ATOM   2178 C CB  . LEU A 1 270 ? -36.043 -6.020  17.821  1.00 27.30 ? 270 LEU A CB  1 
ATOM   2179 C CG  . LEU A 1 270 ? -34.687 -5.638  17.275  1.00 28.70 ? 270 LEU A CG  1 
ATOM   2180 C CD1 . LEU A 1 270 ? -34.538 -6.244  15.889  1.00 24.36 ? 270 LEU A CD1 1 
ATOM   2181 C CD2 . LEU A 1 270 ? -34.593 -4.131  17.214  1.00 31.68 ? 270 LEU A CD2 1 
ATOM   2182 N N   . THR A 1 271 ? -38.738 -5.565  19.431  1.00 28.55 ? 271 THR A N   1 
ATOM   2183 C CA  . THR A 1 271 ? -40.142 -5.954  19.376  1.00 27.40 ? 271 THR A CA  1 
ATOM   2184 C C   . THR A 1 271 ? -40.688 -5.523  18.024  1.00 24.76 ? 271 THR A C   1 
ATOM   2185 O O   . THR A 1 271 ? -40.614 -4.339  17.681  1.00 31.40 ? 271 THR A O   1 
ATOM   2186 C CB  . THR A 1 271 ? -40.927 -5.298  20.514  1.00 28.35 ? 271 THR A CB  1 
ATOM   2187 O OG1 . THR A 1 271 ? -40.238 -5.513  21.753  1.00 30.18 ? 271 THR A OG1 1 
ATOM   2188 C CG2 . THR A 1 271 ? -42.340 -5.870  20.606  1.00 27.69 ? 271 THR A CG2 1 
ATOM   2189 N N   . LEU A 1 272 ? -41.198 -6.477  17.244  1.00 23.35 ? 272 LEU A N   1 
ATOM   2190 C CA  . LEU A 1 272 ? -41.852 -6.181  15.972  1.00 21.82 ? 272 LEU A CA  1 
ATOM   2191 C C   . LEU A 1 272 ? -43.339 -6.485  16.054  1.00 18.90 ? 272 LEU A C   1 
ATOM   2192 O O   . LEU A 1 272 ? -43.751 -7.501  16.631  1.00 16.93 ? 272 LEU A O   1 
ATOM   2193 C CB  . LEU A 1 272 ? -41.242 -6.965  14.799  1.00 22.57 ? 272 LEU A CB  1 
ATOM   2194 C CG  . LEU A 1 272 ? -39.766 -6.791  14.429  1.00 30.06 ? 272 LEU A CG  1 
ATOM   2195 C CD1 . LEU A 1 272 ? -38.867 -7.777  15.137  1.00 24.92 ? 272 LEU A CD1 1 
ATOM   2196 C CD2 . LEU A 1 272 ? -39.607 -6.949  12.916  1.00 31.99 ? 272 LEU A CD2 1 
ATOM   2197 N N   . ARG A 1 273 ? -44.137 -5.604  15.453  1.00 19.21 ? 273 ARG A N   1 
ATOM   2198 C CA  . ARG A 1 273 ? -45.583 -5.733  15.449  1.00 19.50 ? 273 ARG A CA  1 
ATOM   2199 C C   . ARG A 1 273 ? -46.081 -5.401  14.054  1.00 23.35 ? 273 ARG A C   1 
ATOM   2200 O O   . ARG A 1 273 ? -45.586 -4.465  13.423  1.00 24.11 ? 273 ARG A O   1 
ATOM   2201 C CB  . ARG A 1 273 ? -46.230 -4.795  16.485  1.00 20.92 ? 273 ARG A CB  1 
ATOM   2202 C CG  . ARG A 1 273 ? -47.689 -5.120  16.800  1.00 30.11 ? 273 ARG A CG  1 
ATOM   2203 C CD  . ARG A 1 273 ? -48.353 -3.991  17.597  1.00 33.08 ? 273 ARG A CD  1 
ATOM   2204 N NE  . ARG A 1 273 ? -48.301 -4.255  19.028  1.00 38.49 ? 273 ARG A NE  1 
ATOM   2205 C CZ  . ARG A 1 273 ? -47.408 -3.720  19.848  1.00 39.21 ? 273 ARG A CZ  1 
ATOM   2206 N NH1 . ARG A 1 273 ? -46.481 -2.882  19.406  1.00 42.78 ? 273 ARG A NH1 1 
ATOM   2207 N NH2 . ARG A 1 273 ? -47.436 -4.046  21.139  1.00 36.75 ? 273 ARG A NH2 1 
ATOM   2208 N N   . TRP A 1 274 ? -47.038 -6.178  13.568  1.00 17.69 ? 274 TRP A N   1 
ATOM   2209 C CA  . TRP A 1 274 ? -47.592 -5.924  12.243  1.00 19.58 ? 274 TRP A CA  1 
ATOM   2210 C C   . TRP A 1 274 ? -48.547 -4.730  12.251  1.00 28.02 ? 274 TRP A C   1 
ATOM   2211 O O   . TRP A 1 274 ? -49.386 -4.602  13.157  1.00 29.70 ? 274 TRP A O   1 
ATOM   2212 C CB  . TRP A 1 274 ? -48.291 -7.166  11.717  1.00 18.37 ? 274 TRP A CB  1 
ATOM   2213 C CG  . TRP A 1 274 ? -48.881 -6.952  10.367  1.00 21.05 ? 274 TRP A CG  1 
ATOM   2214 C CD1 . TRP A 1 274 ? -50.166 -6.597  10.062  1.00 22.80 ? 274 TRP A CD1 1 
ATOM   2215 C CD2 . TRP A 1 274 ? -48.158 -6.949  9.137   1.00 17.24 ? 274 TRP A CD2 1 
ATOM   2216 N NE1 . TRP A 1 274 ? -50.305 -6.456  8.697   1.00 22.05 ? 274 TRP A NE1 1 
ATOM   2217 C CE2 . TRP A 1 274 ? -49.080 -6.660  8.108   1.00 19.03 ? 274 TRP A CE2 1 
ATOM   2218 C CE3 . TRP A 1 274 ? -46.826 -7.207  8.803   1.00 15.50 ? 274 TRP A CE3 1 
ATOM   2219 C CZ2 . TRP A 1 274 ? -48.705 -6.604  6.769   1.00 16.20 ? 274 TRP A CZ2 1 
ATOM   2220 C CZ3 . TRP A 1 274 ? -46.448 -7.154  7.478   1.00 13.91 ? 274 TRP A CZ3 1 
ATOM   2221 C CH2 . TRP A 1 274 ? -47.387 -6.859  6.470   1.00 18.85 ? 274 TRP A CH2 1 
ATOM   2222 N N   . MET B 2 1   ? -29.757 -49.448 15.994  1.00 56.51 ? 0   MET B N   1 
ATOM   2223 C CA  . MET B 2 1   ? -29.080 -48.417 15.213  1.00 49.46 ? 0   MET B CA  1 
ATOM   2224 C C   . MET B 2 1   ? -29.966 -47.176 15.111  1.00 50.84 ? 0   MET B C   1 
ATOM   2225 O O   . MET B 2 1   ? -31.178 -47.274 14.886  1.00 47.87 ? 0   MET B O   1 
ATOM   2226 C CB  . MET B 2 1   ? -28.718 -48.950 13.820  1.00 51.42 ? 0   MET B CB  1 
ATOM   2227 C CG  . MET B 2 1   ? -28.685 -47.902 12.700  1.00 53.13 ? 0   MET B CG  1 
ATOM   2228 S SD  . MET B 2 1   ? -27.032 -47.263 12.319  1.00 49.83 ? 0   MET B SD  1 
ATOM   2229 C CE  . MET B 2 1   ? -26.300 -48.698 11.522  1.00 35.19 ? 0   MET B CE  1 
ATOM   2230 N N   . ILE B 2 2   ? -29.347 -46.010 15.276  1.00 49.89 ? 1   ILE B N   1 
ATOM   2231 C CA  . ILE B 2 2   ? -30.057 -44.734 15.298  1.00 46.98 ? 1   ILE B CA  1 
ATOM   2232 C C   . ILE B 2 2   ? -30.252 -44.245 13.869  1.00 40.44 ? 1   ILE B C   1 
ATOM   2233 O O   . ILE B 2 2   ? -29.288 -44.159 13.094  1.00 43.55 ? 1   ILE B O   1 
ATOM   2234 C CB  . ILE B 2 2   ? -29.295 -43.693 16.142  1.00 41.42 ? 1   ILE B CB  1 
ATOM   2235 C CG1 . ILE B 2 2   ? -29.330 -44.049 17.639  1.00 44.23 ? 1   ILE B CG1 1 
ATOM   2236 C CG2 . ILE B 2 2   ? -29.846 -42.284 15.910  1.00 39.44 ? 1   ILE B CG2 1 
ATOM   2237 C CD1 . ILE B 2 2   ? -28.490 -45.249 18.067  1.00 43.34 ? 1   ILE B CD1 1 
ATOM   2238 N N   . GLN B 2 3   ? -31.499 -43.937 13.515  1.00 37.05 ? 2   GLN B N   1 
ATOM   2239 C CA  . GLN B 2 3   ? -31.818 -43.352 12.219  1.00 28.32 ? 2   GLN B CA  1 
ATOM   2240 C C   . GLN B 2 3   ? -32.738 -42.161 12.435  1.00 22.93 ? 2   GLN B C   1 
ATOM   2241 O O   . GLN B 2 3   ? -33.772 -42.285 13.102  1.00 26.96 ? 2   GLN B O   1 
ATOM   2242 C CB  . GLN B 2 3   ? -32.462 -44.382 11.286  1.00 32.67 ? 2   GLN B CB  1 
ATOM   2243 C CG  . GLN B 2 3   ? -31.423 -45.278 10.630  1.00 34.31 ? 2   GLN B CG  1 
ATOM   2244 C CD  . GLN B 2 3   ? -31.968 -46.118 9.494   1.00 36.95 ? 2   GLN B CD  1 
ATOM   2245 O OE1 . GLN B 2 3   ? -33.166 -46.097 9.198   1.00 39.02 ? 2   GLN B OE1 1 
ATOM   2246 N NE2 . GLN B 2 3   ? -31.081 -46.869 8.847   1.00 38.48 ? 2   GLN B NE2 1 
ATOM   2247 N N   . ARG B 2 4   ? -32.349 -41.002 11.905  1.00 18.56 ? 3   ARG B N   1 
ATOM   2248 C CA  . ARG B 2 4   ? -33.137 -39.784 12.032  1.00 18.57 ? 3   ARG B CA  1 
ATOM   2249 C C   . ARG B 2 4   ? -33.356 -39.192 10.658  1.00 17.82 ? 3   ARG B C   1 
ATOM   2250 O O   . ARG B 2 4   ? -32.402 -39.055 9.877   1.00 14.64 ? 3   ARG B O   1 
ATOM   2251 C CB  . ARG B 2 4   ? -32.479 -38.720 12.920  1.00 18.17 ? 3   ARG B CB  1 
ATOM   2252 C CG  . ARG B 2 4   ? -32.111 -39.173 14.312  1.00 22.93 ? 3   ARG B CG  1 
ATOM   2253 C CD  . ARG B 2 4   ? -31.804 -37.945 15.112  1.00 24.86 ? 3   ARG B CD  1 
ATOM   2254 N NE  . ARG B 2 4   ? -30.574 -38.070 15.879  1.00 29.78 ? 3   ARG B NE  1 
ATOM   2255 C CZ  . ARG B 2 4   ? -30.110 -37.109 16.668  1.00 33.50 ? 3   ARG B CZ  1 
ATOM   2256 N NH1 . ARG B 2 4   ? -30.780 -35.973 16.837  1.00 31.58 ? 3   ARG B NH1 1 
ATOM   2257 N NH2 . ARG B 2 4   ? -28.935 -37.277 17.278  1.00 29.25 ? 3   ARG B NH2 1 
ATOM   2258 N N   . THR B 2 5   ? -34.614 -38.812 10.382  1.00 16.66 ? 4   THR B N   1 
ATOM   2259 C CA  . THR B 2 5   ? -34.996 -38.289 9.082   1.00 15.54 ? 4   THR B CA  1 
ATOM   2260 C C   . THR B 2 5   ? -34.596 -36.820 8.938   1.00 16.29 ? 4   THR B C   1 
ATOM   2261 O O   . THR B 2 5   ? -34.686 -36.045 9.894   1.00 18.32 ? 4   THR B O   1 
ATOM   2262 C CB  . THR B 2 5   ? -36.501 -38.455 8.856   1.00 18.95 ? 4   THR B CB  1 
ATOM   2263 O OG1 . THR B 2 5   ? -36.776 -38.309 7.459   1.00 24.35 ? 4   THR B OG1 1 
ATOM   2264 C CG2 . THR B 2 5   ? -37.299 -37.439 9.641   1.00 24.08 ? 4   THR B CG2 1 
ATOM   2265 N N   . PRO B 2 6   ? -34.137 -36.413 7.758   1.00 15.23 ? 5   PRO B N   1 
ATOM   2266 C CA  . PRO B 2 6   ? -33.702 -35.025 7.588   1.00 13.63 ? 5   PRO B CA  1 
ATOM   2267 C C   . PRO B 2 6   ? -34.835 -34.031 7.727   1.00 20.12 ? 5   PRO B C   1 
ATOM   2268 O O   . PRO B 2 6   ? -35.962 -34.270 7.292   1.00 18.01 ? 5   PRO B O   1 
ATOM   2269 C CB  . PRO B 2 6   ? -33.121 -34.999 6.168   1.00 14.73 ? 5   PRO B CB  1 
ATOM   2270 C CG  . PRO B 2 6   ? -33.634 -36.216 5.507   1.00 18.20 ? 5   PRO B CG  1 
ATOM   2271 C CD  . PRO B 2 6   ? -33.796 -37.242 6.592   1.00 16.91 ? 5   PRO B CD  1 
ATOM   2272 N N   . LYS B 2 7   ? -34.512 -32.900 8.328   1.00 16.56 ? 6   LYS B N   1 
ATOM   2273 C CA  . LYS B 2 7   ? -35.332 -31.710 8.205   1.00 17.78 ? 6   LYS B CA  1 
ATOM   2274 C C   . LYS B 2 7   ? -34.823 -30.926 7.009   1.00 18.93 ? 6   LYS B C   1 
ATOM   2275 O O   . LYS B 2 7   ? -33.612 -30.772 6.837   1.00 18.88 ? 6   LYS B O   1 
ATOM   2276 C CB  . LYS B 2 7   ? -35.286 -30.874 9.484   1.00 22.51 ? 6   LYS B CB  1 
ATOM   2277 C CG  . LYS B 2 7   ? -35.940 -31.578 10.683  1.00 24.12 ? 6   LYS B CG  1 
ATOM   2278 C CD  . LYS B 2 7   ? -34.942 -32.456 11.417  1.00 30.78 ? 6   LYS B CD  1 
ATOM   2279 C CE  . LYS B 2 7   ? -35.592 -33.764 11.906  1.00 38.40 ? 6   LYS B CE  1 
ATOM   2280 N NZ  . LYS B 2 7   ? -34.575 -34.707 12.485  1.00 31.34 ? 6   LYS B NZ  1 
ATOM   2281 N N   . ILE B 2 8   ? -35.738 -30.471 6.164   1.00 14.46 ? 7   ILE B N   1 
ATOM   2282 C CA  . ILE B 2 8   ? -35.384 -29.905 4.869   1.00 15.58 ? 7   ILE B CA  1 
ATOM   2283 C C   . ILE B 2 8   ? -35.888 -28.476 4.804   1.00 17.34 ? 7   ILE B C   1 
ATOM   2284 O O   . ILE B 2 8   ? -37.054 -28.209 5.116   1.00 15.99 ? 7   ILE B O   1 
ATOM   2285 C CB  . ILE B 2 8   ? -35.964 -30.747 3.716   1.00 15.87 ? 7   ILE B CB  1 
ATOM   2286 C CG1 . ILE B 2 8   ? -35.545 -32.212 3.879   1.00 17.06 ? 7   ILE B CG1 1 
ATOM   2287 C CG2 . ILE B 2 8   ? -35.555 -30.176 2.362   1.00 16.21 ? 7   ILE B CG2 1 
ATOM   2288 C CD1 . ILE B 2 8   ? -36.376 -33.177 3.075   1.00 17.40 ? 7   ILE B CD1 1 
ATOM   2289 N N   . GLN B 2 9   ? -35.020 -27.570 4.373   1.00 12.22 ? 8   GLN B N   1 
ATOM   2290 C CA  . GLN B 2 9   ? -35.375 -26.177 4.137   1.00 17.34 ? 8   GLN B CA  1 
ATOM   2291 C C   . GLN B 2 9   ? -34.844 -25.762 2.772   1.00 14.01 ? 8   GLN B C   1 
ATOM   2292 O O   . GLN B 2 9   ? -33.651 -25.908 2.502   1.00 14.17 ? 8   GLN B O   1 
ATOM   2293 C CB  . GLN B 2 9   ? -34.780 -25.282 5.233   1.00 14.22 ? 8   GLN B CB  1 
ATOM   2294 C CG  . GLN B 2 9   ? -35.412 -25.526 6.607   1.00 15.14 ? 8   GLN B CG  1 
ATOM   2295 C CD  . GLN B 2 9   ? -35.146 -24.391 7.557   1.00 17.42 ? 8   GLN B CD  1 
ATOM   2296 O OE1 . GLN B 2 9   ? -35.647 -23.283 7.370   1.00 15.88 ? 8   GLN B OE1 1 
ATOM   2297 N NE2 . GLN B 2 9   ? -34.321 -24.650 8.578   1.00 11.80 ? 8   GLN B NE2 1 
ATOM   2298 N N   . VAL B 2 10  ? -35.716 -25.234 1.917   1.00 12.29 ? 9   VAL B N   1 
ATOM   2299 C CA  . VAL B 2 10  ? -35.312 -24.703 0.621   1.00 13.55 ? 9   VAL B CA  1 
ATOM   2300 C C   . VAL B 2 10  ? -35.615 -23.211 0.612   1.00 15.65 ? 9   VAL B C   1 
ATOM   2301 O O   . VAL B 2 10  ? -36.701 -22.788 1.021   1.00 14.63 ? 9   VAL B O   1 
ATOM   2302 C CB  . VAL B 2 10  ? -35.989 -25.457 -0.548  1.00 16.89 ? 9   VAL B CB  1 
ATOM   2303 C CG1 . VAL B 2 10  ? -37.459 -25.282 -0.528  1.00 20.18 ? 9   VAL B CG1 1 
ATOM   2304 C CG2 . VAL B 2 10  ? -35.460 -24.952 -1.887  1.00 19.56 ? 9   VAL B CG2 1 
ATOM   2305 N N   . TYR B 2 11  ? -34.636 -22.408 0.203   1.00 13.98 ? 10  TYR B N   1 
ATOM   2306 C CA  . TYR B 2 11  ? -34.735 -20.962 0.377   1.00 15.36 ? 10  TYR B CA  1 
ATOM   2307 C C   . TYR B 2 11  ? -33.656 -20.275 -0.431  1.00 16.08 ? 10  TYR B C   1 
ATOM   2308 O O   . TYR B 2 11  ? -32.665 -20.891 -0.826  1.00 17.11 ? 10  TYR B O   1 
ATOM   2309 C CB  . TYR B 2 11  ? -34.599 -20.550 1.841   1.00 14.90 ? 10  TYR B CB  1 
ATOM   2310 C CG  . TYR B 2 11  ? -33.322 -21.022 2.506   1.00 12.31 ? 10  TYR B CG  1 
ATOM   2311 C CD1 . TYR B 2 11  ? -33.191 -22.340 2.916   1.00 13.51 ? 10  TYR B CD1 1 
ATOM   2312 C CD2 . TYR B 2 11  ? -32.268 -20.145 2.764   1.00 14.74 ? 10  TYR B CD2 1 
ATOM   2313 C CE1 . TYR B 2 11  ? -32.048 -22.786 3.552   1.00 13.84 ? 10  TYR B CE1 1 
ATOM   2314 C CE2 . TYR B 2 11  ? -31.103 -20.593 3.407   1.00 11.50 ? 10  TYR B CE2 1 
ATOM   2315 C CZ  . TYR B 2 11  ? -31.006 -21.913 3.783   1.00 10.49 ? 10  TYR B CZ  1 
ATOM   2316 O OH  . TYR B 2 11  ? -29.890 -22.401 4.418   1.00 13.37 ? 10  TYR B OH  1 
ATOM   2317 N N   . SER B 2 12  ? -33.846 -18.980 -0.635  1.00 17.95 ? 11  SER B N   1 
ATOM   2318 C CA  . SER B 2 12  ? -32.854 -18.162 -1.310  1.00 18.91 ? 11  SER B CA  1 
ATOM   2319 C C   . SER B 2 12  ? -31.998 -17.416 -0.286  1.00 19.47 ? 11  SER B C   1 
ATOM   2320 O O   . SER B 2 12  ? -32.400 -17.197 0.860   1.00 17.34 ? 11  SER B O   1 
ATOM   2321 C CB  . SER B 2 12  ? -33.536 -17.193 -2.280  1.00 19.12 ? 11  SER B CB  1 
ATOM   2322 O OG  . SER B 2 12  ? -34.527 -16.441 -1.615  1.00 22.13 ? 11  SER B OG  1 
ATOM   2323 N N   . ARG B 2 13  ? -30.788 -17.048 -0.709  1.00 15.29 ? 12  ARG B N   1 
ATOM   2324 C CA  . ARG B 2 13  ? -29.895 -16.368 0.225   1.00 20.25 ? 12  ARG B CA  1 
ATOM   2325 C C   . ARG B 2 13  ? -30.422 -14.988 0.589   1.00 22.70 ? 12  ARG B C   1 
ATOM   2326 O O   . ARG B 2 13  ? -30.253 -14.542 1.733   1.00 22.46 ? 12  ARG B O   1 
ATOM   2327 C CB  . ARG B 2 13  ? -28.490 -16.271 -0.359  1.00 17.34 ? 12  ARG B CB  1 
ATOM   2328 C CG  . ARG B 2 13  ? -27.518 -15.516 0.530   1.00 20.47 ? 12  ARG B CG  1 
ATOM   2329 C CD  . ARG B 2 13  ? -26.230 -15.319 -0.207  1.00 21.79 ? 12  ARG B CD  1 
ATOM   2330 N NE  . ARG B 2 13  ? -25.577 -16.608 -0.406  1.00 22.47 ? 12  ARG B NE  1 
ATOM   2331 C CZ  . ARG B 2 13  ? -24.366 -16.763 -0.922  1.00 24.19 ? 12  ARG B CZ  1 
ATOM   2332 N NH1 . ARG B 2 13  ? -23.636 -15.721 -1.294  1.00 19.11 ? 12  ARG B NH1 1 
ATOM   2333 N NH2 . ARG B 2 13  ? -23.886 -17.992 -1.089  1.00 19.73 ? 12  ARG B NH2 1 
ATOM   2334 N N   . HIS B 2 14  ? -31.079 -14.322 -0.353  1.00 22.92 ? 13  HIS B N   1 
ATOM   2335 C CA  . HIS B 2 14  ? -31.688 -13.010 -0.211  1.00 23.49 ? 13  HIS B CA  1 
ATOM   2336 C C   . HIS B 2 14  ? -33.144 -13.110 -0.637  1.00 22.92 ? 13  HIS B C   1 
ATOM   2337 O O   . HIS B 2 14  ? -33.488 -13.981 -1.442  1.00 22.37 ? 13  HIS B O   1 
ATOM   2338 C CB  . HIS B 2 14  ? -30.961 -11.990 -1.100  1.00 24.31 ? 13  HIS B CB  1 
ATOM   2339 C CG  . HIS B 2 14  ? -29.510 -11.832 -0.778  1.00 25.82 ? 13  HIS B CG  1 
ATOM   2340 N ND1 . HIS B 2 14  ? -29.060 -11.384 0.445   1.00 30.20 ? 13  HIS B ND1 1 
ATOM   2341 C CD2 . HIS B 2 14  ? -28.403 -12.106 -1.508  1.00 25.50 ? 13  HIS B CD2 1 
ATOM   2342 C CE1 . HIS B 2 14  ? -27.738 -11.365 0.446   1.00 27.92 ? 13  HIS B CE1 1 
ATOM   2343 N NE2 . HIS B 2 14  ? -27.314 -11.803 -0.726  1.00 28.05 ? 13  HIS B NE2 1 
ATOM   2344 N N   . PRO B 2 15  ? -34.027 -12.246 -0.120  1.00 20.90 ? 14  PRO B N   1 
ATOM   2345 C CA  . PRO B 2 15  ? -35.420 -12.271 -0.598  1.00 23.45 ? 14  PRO B CA  1 
ATOM   2346 C C   . PRO B 2 15  ? -35.453 -12.124 -2.112  1.00 23.52 ? 14  PRO B C   1 
ATOM   2347 O O   . PRO B 2 15  ? -34.708 -11.334 -2.690  1.00 24.59 ? 14  PRO B O   1 
ATOM   2348 C CB  . PRO B 2 15  ? -36.073 -11.074 0.110   1.00 22.98 ? 14  PRO B CB  1 
ATOM   2349 C CG  . PRO B 2 15  ? -35.242 -10.867 1.350   1.00 24.15 ? 14  PRO B CG  1 
ATOM   2350 C CD  . PRO B 2 15  ? -33.822 -11.255 0.951   1.00 23.07 ? 14  PRO B CD  1 
ATOM   2351 N N   . ALA B 2 16  ? -36.294 -12.926 -2.760  1.00 22.60 ? 15  ALA B N   1 
ATOM   2352 C CA  . ALA B 2 16  ? -36.194 -13.058 -4.207  1.00 23.54 ? 15  ALA B CA  1 
ATOM   2353 C C   . ALA B 2 16  ? -36.748 -11.822 -4.907  1.00 26.36 ? 15  ALA B C   1 
ATOM   2354 O O   . ALA B 2 16  ? -37.812 -11.307 -4.550  1.00 25.29 ? 15  ALA B O   1 
ATOM   2355 C CB  . ALA B 2 16  ? -36.945 -14.304 -4.676  1.00 27.76 ? 15  ALA B CB  1 
ATOM   2356 N N   . GLU B 2 17  ? -36.011 -11.347 -5.910  1.00 24.76 ? 16  GLU B N   1 
ATOM   2357 C CA  . GLU B 2 17  ? -36.487 -10.327 -6.837  1.00 24.82 ? 16  GLU B CA  1 
ATOM   2358 C C   . GLU B 2 17  ? -36.245 -10.851 -8.244  1.00 30.43 ? 16  GLU B C   1 
ATOM   2359 O O   . GLU B 2 17  ? -35.109 -11.192 -8.588  1.00 27.34 ? 16  GLU B O   1 
ATOM   2360 C CB  . GLU B 2 17  ? -35.774 -8.980  -6.636  1.00 28.59 ? 16  GLU B CB  1 
ATOM   2361 C CG  . GLU B 2 17  ? -35.394 -8.613  -5.189  1.00 34.08 ? 16  GLU B CG  1 
ATOM   2362 C CD  . GLU B 2 17  ? -33.887 -8.786  -4.856  1.00 46.80 ? 16  GLU B CD  1 
ATOM   2363 O OE1 . GLU B 2 17  ? -33.378 -9.940  -4.769  1.00 44.02 ? 16  GLU B OE1 1 
ATOM   2364 O OE2 . GLU B 2 17  ? -33.206 -7.749  -4.656  1.00 50.41 ? 16  GLU B OE2 1 
ATOM   2365 N N   . ASN B 2 18  ? -37.302 -10.920 -9.049  1.00 25.01 ? 17  ASN B N   1 
ATOM   2366 C CA  . ASN B 2 18  ? -37.164 -11.424 -10.413 1.00 28.37 ? 17  ASN B CA  1 
ATOM   2367 C C   . ASN B 2 18  ? -36.125 -10.626 -11.188 1.00 28.59 ? 17  ASN B C   1 
ATOM   2368 O O   . ASN B 2 18  ? -36.121 -9.394  -11.162 1.00 31.29 ? 17  ASN B O   1 
ATOM   2369 C CB  . ASN B 2 18  ? -38.512 -11.381 -11.129 1.00 28.69 ? 17  ASN B CB  1 
ATOM   2370 C CG  . ASN B 2 18  ? -39.470 -12.420 -10.605 1.00 29.27 ? 17  ASN B CG  1 
ATOM   2371 O OD1 . ASN B 2 18  ? -39.057 -13.502 -10.184 1.00 31.00 ? 17  ASN B OD1 1 
ATOM   2372 N ND2 . ASN B 2 18  ? -40.757 -12.114 -10.644 1.00 31.56 ? 17  ASN B ND2 1 
ATOM   2373 N N   . GLY B 2 19  ? -35.229 -11.336 -11.870 1.00 25.82 ? 18  GLY B N   1 
ATOM   2374 C CA  . GLY B 2 19  ? -34.175 -10.702 -12.624 1.00 26.54 ? 18  GLY B CA  1 
ATOM   2375 C C   . GLY B 2 19  ? -32.915 -10.380 -11.851 1.00 31.84 ? 18  GLY B C   1 
ATOM   2376 O O   . GLY B 2 19  ? -31.932 -9.941  -12.462 1.00 32.07 ? 18  GLY B O   1 
ATOM   2377 N N   . LYS B 2 20  ? -32.890 -10.589 -10.536 1.00 28.37 ? 19  LYS B N   1 
ATOM   2378 C CA  . LYS B 2 20  ? -31.735 -10.217 -9.725  1.00 29.37 ? 19  LYS B CA  1 
ATOM   2379 C C   . LYS B 2 20  ? -31.013 -11.476 -9.256  1.00 26.81 ? 19  LYS B C   1 
ATOM   2380 O O   . LYS B 2 20  ? -31.631 -12.365 -8.664  1.00 24.89 ? 19  LYS B O   1 
ATOM   2381 C CB  . LYS B 2 20  ? -32.167 -9.350  -8.534  1.00 31.93 ? 19  LYS B CB  1 
ATOM   2382 C CG  . LYS B 2 20  ? -32.396 -7.859  -8.884  1.00 35.39 ? 19  LYS B CG  1 
ATOM   2383 C CD  . LYS B 2 20  ? -31.088 -7.130  -9.236  1.00 41.32 ? 19  LYS B CD  1 
ATOM   2384 C CE  . LYS B 2 20  ? -30.956 -6.851  -10.743 1.00 44.97 ? 19  LYS B CE  1 
ATOM   2385 N NZ  . LYS B 2 20  ? -29.529 -6.815  -11.194 1.00 42.17 ? 19  LYS B NZ  1 
ATOM   2386 N N   . SER B 2 21  ? -29.713 -11.554 -9.530  1.00 25.99 ? 20  SER B N   1 
ATOM   2387 C CA  . SER B 2 21  ? -28.931 -12.726 -9.158  1.00 27.09 ? 20  SER B CA  1 
ATOM   2388 C C   . SER B 2 21  ? -29.026 -13.021 -7.665  1.00 23.64 ? 20  SER B C   1 
ATOM   2389 O O   . SER B 2 21  ? -29.163 -12.122 -6.836  1.00 25.12 ? 20  SER B O   1 
ATOM   2390 C CB  . SER B 2 21  ? -27.468 -12.536 -9.542  1.00 28.74 ? 20  SER B CB  1 
ATOM   2391 O OG  . SER B 2 21  ? -26.848 -13.801 -9.670  1.00 34.40 ? 20  SER B OG  1 
ATOM   2392 N N   . ASN B 2 22  ? -28.913 -14.300 -7.325  1.00 21.64 ? 21  ASN B N   1 
ATOM   2393 C CA  . ASN B 2 22  ? -29.215 -14.783 -5.983  1.00 19.83 ? 21  ASN B CA  1 
ATOM   2394 C C   . ASN B 2 22  ? -28.594 -16.169 -5.844  1.00 20.38 ? 21  ASN B C   1 
ATOM   2395 O O   . ASN B 2 22  ? -27.925 -16.662 -6.754  1.00 20.45 ? 21  ASN B O   1 
ATOM   2396 C CB  . ASN B 2 22  ? -30.731 -14.808 -5.766  1.00 17.93 ? 21  ASN B CB  1 
ATOM   2397 C CG  . ASN B 2 22  ? -31.141 -14.615 -4.310  1.00 19.09 ? 21  ASN B CG  1 
ATOM   2398 O OD1 . ASN B 2 22  ? -30.425 -15.004 -3.382  1.00 20.15 ? 21  ASN B OD1 1 
ATOM   2399 N ND2 . ASN B 2 22  ? -32.315 -14.028 -4.110  1.00 18.47 ? 21  ASN B ND2 1 
ATOM   2400 N N   . PHE B 2 23  ? -28.846 -16.809 -4.710  1.00 16.57 ? 22  PHE B N   1 
ATOM   2401 C CA  . PHE B 2 23  ? -28.414 -18.178 -4.476  1.00 17.84 ? 22  PHE B CA  1 
ATOM   2402 C C   . PHE B 2 23  ? -29.598 -18.988 -3.985  1.00 15.30 ? 22  PHE B C   1 
ATOM   2403 O O   . PHE B 2 23  ? -30.342 -18.534 -3.113  1.00 16.68 ? 22  PHE B O   1 
ATOM   2404 C CB  . PHE B 2 23  ? -27.288 -18.245 -3.427  1.00 18.78 ? 22  PHE B CB  1 
ATOM   2405 C CG  . PHE B 2 23  ? -25.942 -17.916 -3.977  1.00 18.71 ? 22  PHE B CG  1 
ATOM   2406 C CD1 . PHE B 2 23  ? -25.549 -16.596 -4.117  1.00 19.64 ? 22  PHE B CD1 1 
ATOM   2407 C CD2 . PHE B 2 23  ? -25.071 -18.925 -4.368  1.00 23.61 ? 22  PHE B CD2 1 
ATOM   2408 C CE1 . PHE B 2 23  ? -24.314 -16.287 -4.640  1.00 22.65 ? 22  PHE B CE1 1 
ATOM   2409 C CE2 . PHE B 2 23  ? -23.820 -18.621 -4.889  1.00 25.00 ? 22  PHE B CE2 1 
ATOM   2410 C CZ  . PHE B 2 23  ? -23.446 -17.297 -5.018  1.00 23.30 ? 22  PHE B CZ  1 
ATOM   2411 N N   . LEU B 2 24  ? -29.760 -20.186 -4.532  1.00 15.05 ? 23  LEU B N   1 
ATOM   2412 C CA  . LEU B 2 24  ? -30.787 -21.121 -4.096  1.00 18.13 ? 23  LEU B CA  1 
ATOM   2413 C C   . LEU B 2 24  ? -30.138 -22.119 -3.143  1.00 17.71 ? 23  LEU B C   1 
ATOM   2414 O O   . LEU B 2 24  ? -29.153 -22.765 -3.510  1.00 15.50 ? 23  LEU B O   1 
ATOM   2415 C CB  . LEU B 2 24  ? -31.413 -21.848 -5.290  1.00 17.78 ? 23  LEU B CB  1 
ATOM   2416 C CG  . LEU B 2 24  ? -32.443 -22.908 -4.908  1.00 19.21 ? 23  LEU B CG  1 
ATOM   2417 C CD1 . LEU B 2 24  ? -33.682 -22.282 -4.248  1.00 18.05 ? 23  LEU B CD1 1 
ATOM   2418 C CD2 . LEU B 2 24  ? -32.790 -23.749 -6.135  1.00 26.00 ? 23  LEU B CD2 1 
ATOM   2419 N N   . ASN B 2 25  ? -30.685 -22.243 -1.927  1.00 15.86 ? 24  ASN B N   1 
ATOM   2420 C CA  . ASN B 2 25  ? -30.134 -23.153 -0.931  1.00 14.89 ? 24  ASN B CA  1 
ATOM   2421 C C   . ASN B 2 25  ? -31.113 -24.265 -0.597  1.00 15.57 ? 24  ASN B C   1 
ATOM   2422 O O   . ASN B 2 25  ? -32.324 -24.061 -0.577  1.00 14.36 ? 24  ASN B O   1 
ATOM   2423 C CB  . ASN B 2 25  ? -29.749 -22.439 0.375   1.00 13.69 ? 24  ASN B CB  1 
ATOM   2424 C CG  . ASN B 2 25  ? -28.761 -21.329 0.158   1.00 15.18 ? 24  ASN B CG  1 
ATOM   2425 O OD1 . ASN B 2 25  ? -27.772 -21.501 -0.554  1.00 16.42 ? 24  ASN B OD1 1 
ATOM   2426 N ND2 . ASN B 2 25  ? -28.968 -20.211 0.837   1.00 18.57 ? 24  ASN B ND2 1 
ATOM   2427 N N   . CYS B 2 26  ? -30.563 -25.449 -0.328  1.00 15.40 ? 25  CYS B N   1 
ATOM   2428 C CA  . CYS B 2 26  ? -31.293 -26.535 0.316   1.00 14.85 ? 25  CYS B CA  1 
ATOM   2429 C C   . CYS B 2 26  ? -30.453 -26.984 1.503   1.00 17.65 ? 25  CYS B C   1 
ATOM   2430 O O   . CYS B 2 26  ? -29.341 -27.503 1.331   1.00 15.58 ? 25  CYS B O   1 
ATOM   2431 C CB  . CYS B 2 26  ? -31.557 -27.698 -0.633  1.00 16.61 ? 25  CYS B CB  1 
ATOM   2432 S SG  . CYS B 2 26  ? -32.567 -28.991 0.118   1.00 19.94 ? 25  CYS B SG  1 
ATOM   2433 N N   . TYR B 2 27  ? -30.969 -26.742 2.704   1.00 13.96 ? 26  TYR B N   1 
ATOM   2434 C CA  . TYR B 2 27  ? -30.280 -27.042 3.948   1.00 14.31 ? 26  TYR B CA  1 
ATOM   2435 C C   . TYR B 2 27  ? -30.940 -28.268 4.557   1.00 14.43 ? 26  TYR B C   1 
ATOM   2436 O O   . TYR B 2 27  ? -32.136 -28.238 4.869   1.00 13.76 ? 26  TYR B O   1 
ATOM   2437 C CB  . TYR B 2 27  ? -30.354 -25.838 4.886   1.00 13.59 ? 26  TYR B CB  1 
ATOM   2438 C CG  . TYR B 2 27  ? -29.669 -26.038 6.222   1.00 14.50 ? 26  TYR B CG  1 
ATOM   2439 C CD1 . TYR B 2 27  ? -28.306 -26.303 6.295   1.00 12.79 ? 26  TYR B CD1 1 
ATOM   2440 C CD2 . TYR B 2 27  ? -30.382 -25.929 7.407   1.00 14.96 ? 26  TYR B CD2 1 
ATOM   2441 C CE1 . TYR B 2 27  ? -27.678 -26.473 7.522   1.00 15.73 ? 26  TYR B CE1 1 
ATOM   2442 C CE2 . TYR B 2 27  ? -29.762 -26.099 8.633   1.00 19.32 ? 26  TYR B CE2 1 
ATOM   2443 C CZ  . TYR B 2 27  ? -28.422 -26.370 8.680   1.00 17.04 ? 26  TYR B CZ  1 
ATOM   2444 O OH  . TYR B 2 27  ? -27.807 -26.537 9.889   1.00 20.51 ? 26  TYR B OH  1 
ATOM   2445 N N   . VAL B 2 28  ? -30.183 -29.355 4.694   1.00 11.07 ? 27  VAL B N   1 
ATOM   2446 C CA  . VAL B 2 28  ? -30.669 -30.574 5.333   1.00 12.75 ? 27  VAL B CA  1 
ATOM   2447 C C   . VAL B 2 28  ? -29.964 -30.736 6.669   1.00 15.24 ? 27  VAL B C   1 
ATOM   2448 O O   . VAL B 2 28  ? -28.736 -30.622 6.748   1.00 12.17 ? 27  VAL B O   1 
ATOM   2449 C CB  . VAL B 2 28  ? -30.469 -31.814 4.447   1.00 10.69 ? 27  VAL B CB  1 
ATOM   2450 C CG1 . VAL B 2 28  ? -31.493 -31.805 3.303   1.00 20.24 ? 27  VAL B CG1 1 
ATOM   2451 C CG2 . VAL B 2 28  ? -29.076 -31.825 3.874   1.00 16.34 ? 27  VAL B CG2 1 
ATOM   2452 N N   . SER B 2 29  ? -30.734 -31.007 7.719   1.00 15.64 ? 28  SER B N   1 
ATOM   2453 C CA  . SER B 2 29  ? -30.148 -31.088 9.046   1.00 13.45 ? 28  SER B CA  1 
ATOM   2454 C C   . SER B 2 29  ? -30.851 -32.176 9.849   1.00 17.15 ? 28  SER B C   1 
ATOM   2455 O O   . SER B 2 29  ? -31.921 -32.670 9.481   1.00 15.58 ? 28  SER B O   1 
ATOM   2456 C CB  . SER B 2 29  ? -30.232 -29.748 9.796   1.00 17.79 ? 28  SER B CB  1 
ATOM   2457 O OG  . SER B 2 29  ? -31.569 -29.247 9.848   1.00 18.75 ? 28  SER B OG  1 
ATOM   2458 N N   . GLY B 2 30  ? -30.209 -32.564 10.946  1.00 15.15 ? 29  GLY B N   1 
ATOM   2459 C CA  . GLY B 2 30  ? -30.814 -33.472 11.892  1.00 14.14 ? 29  GLY B CA  1 
ATOM   2460 C C   . GLY B 2 30  ? -30.927 -34.901 11.436  1.00 13.50 ? 29  GLY B C   1 
ATOM   2461 O O   . GLY B 2 30  ? -31.735 -35.636 11.991  1.00 16.46 ? 29  GLY B O   1 
ATOM   2462 N N   . PHE B 2 31  ? -30.134 -35.337 10.460  1.00 11.62 ? 30  PHE B N   1 
ATOM   2463 C CA  . PHE B 2 31  ? -30.301 -36.683 9.936   1.00 13.11 ? 30  PHE B CA  1 
ATOM   2464 C C   . PHE B 2 31  ? -29.179 -37.624 10.353  1.00 15.54 ? 30  PHE B C   1 
ATOM   2465 O O   . PHE B 2 31  ? -28.104 -37.208 10.801  1.00 16.35 ? 30  PHE B O   1 
ATOM   2466 C CB  . PHE B 2 31  ? -30.449 -36.673 8.412   1.00 12.76 ? 30  PHE B CB  1 
ATOM   2467 C CG  . PHE B 2 31  ? -29.286 -36.072 7.660   1.00 13.72 ? 30  PHE B CG  1 
ATOM   2468 C CD1 . PHE B 2 31  ? -29.194 -34.704 7.469   1.00 13.82 ? 30  PHE B CD1 1 
ATOM   2469 C CD2 . PHE B 2 31  ? -28.329 -36.880 7.090   1.00 13.63 ? 30  PHE B CD2 1 
ATOM   2470 C CE1 . PHE B 2 31  ? -28.154 -34.163 6.737   1.00 11.87 ? 30  PHE B CE1 1 
ATOM   2471 C CE2 . PHE B 2 31  ? -27.275 -36.340 6.371   1.00 12.99 ? 30  PHE B CE2 1 
ATOM   2472 C CZ  . PHE B 2 31  ? -27.200 -34.975 6.194   1.00 13.40 ? 30  PHE B CZ  1 
ATOM   2473 N N   . HIS B 2 32  ? -29.464 -38.921 10.213  1.00 13.20 ? 31  HIS B N   1 
ATOM   2474 C CA  . HIS B 2 32  ? -28.515 -39.987 10.495  1.00 18.08 ? 31  HIS B CA  1 
ATOM   2475 C C   . HIS B 2 32  ? -29.050 -41.264 9.860   1.00 19.18 ? 31  HIS B C   1 
ATOM   2476 O O   . HIS B 2 32  ? -30.219 -41.597 10.056  1.00 19.94 ? 31  HIS B O   1 
ATOM   2477 C CB  . HIS B 2 32  ? -28.299 -40.135 12.006  1.00 21.35 ? 31  HIS B CB  1 
ATOM   2478 C CG  . HIS B 2 32  ? -26.945 -40.657 12.369  1.00 20.73 ? 31  HIS B CG  1 
ATOM   2479 N ND1 . HIS B 2 32  ? -26.549 -41.950 12.104  1.00 22.00 ? 31  HIS B ND1 1 
ATOM   2480 C CD2 . HIS B 2 32  ? -25.862 -40.028 12.885  1.00 23.77 ? 31  HIS B CD2 1 
ATOM   2481 C CE1 . HIS B 2 32  ? -25.293 -42.108 12.473  1.00 22.73 ? 31  HIS B CE1 1 
ATOM   2482 N NE2 . HIS B 2 32  ? -24.851 -40.957 12.954  1.00 23.94 ? 31  HIS B NE2 1 
ATOM   2483 N N   . PRO B 2 33  ? -28.239 -42.012 9.105   1.00 19.18 ? 32  PRO B N   1 
ATOM   2484 C CA  . PRO B 2 33  ? -26.809 -41.822 8.857   1.00 20.43 ? 32  PRO B CA  1 
ATOM   2485 C C   . PRO B 2 33  ? -26.515 -40.700 7.877   1.00 15.71 ? 32  PRO B C   1 
ATOM   2486 O O   . PRO B 2 33  ? -27.419 -40.063 7.357   1.00 17.54 ? 32  PRO B O   1 
ATOM   2487 C CB  . PRO B 2 33  ? -26.372 -43.181 8.288   1.00 19.83 ? 32  PRO B CB  1 
ATOM   2488 C CG  . PRO B 2 33  ? -27.646 -43.859 7.789   1.00 23.63 ? 32  PRO B CG  1 
ATOM   2489 C CD  . PRO B 2 33  ? -28.811 -42.984 8.165   1.00 20.60 ? 32  PRO B CD  1 
ATOM   2490 N N   . SER B 2 34  ? -25.226 -40.468 7.611   1.00 19.12 ? 33  SER B N   1 
ATOM   2491 C CA  . SER B 2 34  ? -24.790 -39.331 6.809   1.00 19.77 ? 33  SER B CA  1 
ATOM   2492 C C   . SER B 2 34  ? -24.980 -39.541 5.308   1.00 18.39 ? 33  SER B C   1 
ATOM   2493 O O   . SER B 2 34  ? -25.012 -38.553 4.565   1.00 18.72 ? 33  SER B O   1 
ATOM   2494 C CB  . SER B 2 34  ? -23.319 -39.017 7.126   1.00 17.86 ? 33  SER B CB  1 
ATOM   2495 O OG  . SER B 2 34  ? -22.470 -40.084 6.734   1.00 15.92 ? 33  SER B OG  1 
ATOM   2496 N N   . ASP B 2 35  ? -25.089 -40.786 4.856   1.00 17.87 ? 34  ASP B N   1 
ATOM   2497 C CA  . ASP B 2 35  ? -25.373 -41.087 3.455   1.00 20.62 ? 34  ASP B CA  1 
ATOM   2498 C C   . ASP B 2 35  ? -26.666 -40.420 3.007   1.00 20.05 ? 34  ASP B C   1 
ATOM   2499 O O   . ASP B 2 35  ? -27.743 -40.742 3.513   1.00 18.82 ? 34  ASP B O   1 
ATOM   2500 C CB  . ASP B 2 35  ? -25.483 -42.599 3.267   1.00 26.65 ? 34  ASP B CB  1 
ATOM   2501 C CG  . ASP B 2 35  ? -24.976 -43.061 1.917   1.00 36.73 ? 34  ASP B CG  1 
ATOM   2502 O OD1 . ASP B 2 35  ? -25.581 -42.671 0.899   1.00 40.41 ? 34  ASP B OD1 1 
ATOM   2503 O OD2 . ASP B 2 35  ? -23.983 -43.821 1.872   1.00 50.34 ? 34  ASP B OD2 1 
ATOM   2504 N N   . ILE B 2 36  ? -26.566 -39.507 2.041   1.00 16.61 ? 35  ILE B N   1 
ATOM   2505 C CA  . ILE B 2 36  ? -27.720 -38.735 1.595   1.00 13.43 ? 35  ILE B CA  1 
ATOM   2506 C C   . ILE B 2 36  ? -27.458 -38.207 0.199   1.00 17.30 ? 35  ILE B C   1 
ATOM   2507 O O   . ILE B 2 36  ? -26.312 -37.973 -0.189  1.00 15.72 ? 35  ILE B O   1 
ATOM   2508 C CB  . ILE B 2 36  ? -28.055 -37.596 2.594   1.00 16.94 ? 35  ILE B CB  1 
ATOM   2509 C CG1 . ILE B 2 36  ? -29.474 -37.066 2.347   1.00 14.71 ? 35  ILE B CG1 1 
ATOM   2510 C CG2 . ILE B 2 36  ? -26.985 -36.503 2.589   1.00 15.89 ? 35  ILE B CG2 1 
ATOM   2511 C CD1 . ILE B 2 36  ? -29.948 -36.038 3.402   1.00 17.64 ? 35  ILE B CD1 1 
ATOM   2512 N N   . GLU B 2 37  ? -28.532 -38.027 -0.565  1.00 15.98 ? 36  GLU B N   1 
ATOM   2513 C CA  . GLU B 2 37  ? -28.451 -37.487 -1.911  1.00 16.13 ? 36  GLU B CA  1 
ATOM   2514 C C   . GLU B 2 37  ? -29.371 -36.274 -1.956  1.00 18.21 ? 36  GLU B C   1 
ATOM   2515 O O   . GLU B 2 37  ? -30.559 -36.384 -1.639  1.00 17.30 ? 36  GLU B O   1 
ATOM   2516 C CB  . GLU B 2 37  ? -28.892 -38.527 -2.942  1.00 18.87 ? 36  GLU B CB  1 
ATOM   2517 C CG  . GLU B 2 37  ? -28.720 -38.078 -4.380  1.00 26.22 ? 36  GLU B CG  1 
ATOM   2518 C CD  . GLU B 2 37  ? -28.950 -39.205 -5.387  1.00 27.29 ? 36  GLU B CD  1 
ATOM   2519 O OE1 . GLU B 2 37  ? -29.299 -40.347 -4.974  1.00 25.65 ? 36  GLU B OE1 1 
ATOM   2520 O OE2 . GLU B 2 37  ? -28.699 -38.962 -6.589  1.00 23.19 ? 36  GLU B OE2 1 
ATOM   2521 N N   . VAL B 2 38  ? -28.837 -35.120 -2.335  1.00 13.57 ? 37  VAL B N   1 
ATOM   2522 C CA  . VAL B 2 38  ? -29.626 -33.901 -2.399  1.00 15.40 ? 37  VAL B CA  1 
ATOM   2523 C C   . VAL B 2 38  ? -29.448 -33.295 -3.777  1.00 21.93 ? 37  VAL B C   1 
ATOM   2524 O O   . VAL B 2 38  ? -28.314 -33.073 -4.215  1.00 15.63 ? 37  VAL B O   1 
ATOM   2525 C CB  . VAL B 2 38  ? -29.234 -32.894 -1.314  1.00 16.02 ? 37  VAL B CB  1 
ATOM   2526 C CG1 . VAL B 2 38  ? -30.098 -31.654 -1.418  1.00 13.98 ? 37  VAL B CG1 1 
ATOM   2527 C CG2 . VAL B 2 38  ? -29.415 -33.531 0.049   1.00 19.21 ? 37  VAL B CG2 1 
ATOM   2528 N N   . ASP B 2 39  ? -30.566 -33.049 -4.463  1.00 16.57 ? 38  ASP B N   1 
ATOM   2529 C CA  . ASP B 2 39  ? -30.565 -32.402 -5.766  1.00 19.37 ? 38  ASP B CA  1 
ATOM   2530 C C   . ASP B 2 39  ? -31.468 -31.185 -5.748  1.00 18.90 ? 38  ASP B C   1 
ATOM   2531 O O   . ASP B 2 39  ? -32.529 -31.193 -5.118  1.00 20.71 ? 38  ASP B O   1 
ATOM   2532 C CB  . ASP B 2 39  ? -31.022 -33.353 -6.875  1.00 22.66 ? 38  ASP B CB  1 
ATOM   2533 C CG  . ASP B 2 39  ? -30.074 -34.507 -7.073  1.00 26.42 ? 38  ASP B CG  1 
ATOM   2534 O OD1 . ASP B 2 39  ? -28.950 -34.235 -7.559  1.00 27.03 ? 38  ASP B OD1 1 
ATOM   2535 O OD2 . ASP B 2 39  ? -30.452 -35.671 -6.789  1.00 25.37 ? 38  ASP B OD2 1 
ATOM   2536 N N   . LEU B 2 40  ? -31.041 -30.140 -6.441  1.00 16.33 ? 39  LEU B N   1 
ATOM   2537 C CA  . LEU B 2 40  ? -31.872 -28.971 -6.655  1.00 15.73 ? 39  LEU B CA  1 
ATOM   2538 C C   . LEU B 2 40  ? -32.526 -29.134 -8.016  1.00 19.66 ? 39  LEU B C   1 
ATOM   2539 O O   . LEU B 2 40  ? -31.873 -29.559 -8.968  1.00 19.12 ? 39  LEU B O   1 
ATOM   2540 C CB  . LEU B 2 40  ? -31.041 -27.690 -6.622  1.00 18.47 ? 39  LEU B CB  1 
ATOM   2541 C CG  . LEU B 2 40  ? -30.311 -27.414 -5.298  1.00 19.56 ? 39  LEU B CG  1 
ATOM   2542 C CD1 . LEU B 2 40  ? -29.387 -26.208 -5.445  1.00 21.59 ? 39  LEU B CD1 1 
ATOM   2543 C CD2 . LEU B 2 40  ? -31.287 -27.211 -4.166  1.00 21.68 ? 39  LEU B CD2 1 
ATOM   2544 N N   . LEU B 2 41  ? -33.809 -28.799 -8.107  1.00 16.55 ? 40  LEU B N   1 
ATOM   2545 C CA  . LEU B 2 41  ? -34.575 -29.005 -9.329  1.00 19.82 ? 40  LEU B CA  1 
ATOM   2546 C C   . LEU B 2 41  ? -35.091 -27.675 -9.854  1.00 20.58 ? 40  LEU B C   1 
ATOM   2547 O O   . LEU B 2 41  ? -35.581 -26.844 -9.085  1.00 19.92 ? 40  LEU B O   1 
ATOM   2548 C CB  . LEU B 2 41  ? -35.768 -29.963 -9.107  1.00 19.72 ? 40  LEU B CB  1 
ATOM   2549 C CG  . LEU B 2 41  ? -35.529 -31.312 -8.417  1.00 21.12 ? 40  LEU B CG  1 
ATOM   2550 C CD1 . LEU B 2 41  ? -36.845 -32.078 -8.216  1.00 19.30 ? 40  LEU B CD1 1 
ATOM   2551 C CD2 . LEU B 2 41  ? -34.543 -32.148 -9.210  1.00 20.41 ? 40  LEU B CD2 1 
ATOM   2552 N N   . LYS B 2 42  ? -34.996 -27.486 -11.174 1.00 21.34 ? 41  LYS B N   1 
ATOM   2553 C CA  . LYS B 2 42  ? -35.559 -26.322 -11.849 1.00 21.23 ? 41  LYS B CA  1 
ATOM   2554 C C   . LYS B 2 42  ? -36.608 -26.840 -12.827 1.00 22.12 ? 41  LYS B C   1 
ATOM   2555 O O   . LYS B 2 42  ? -36.266 -27.511 -13.807 1.00 26.22 ? 41  LYS B O   1 
ATOM   2556 C CB  . LYS B 2 42  ? -34.474 -25.516 -12.566 1.00 23.51 ? 41  LYS B CB  1 
ATOM   2557 C CG  . LYS B 2 42  ? -35.000 -24.385 -13.450 1.00 23.51 ? 41  LYS B CG  1 
ATOM   2558 C CD  . LYS B 2 42  ? -33.865 -23.523 -13.973 1.00 24.77 ? 41  LYS B CD  1 
ATOM   2559 C CE  . LYS B 2 42  ? -34.334 -22.465 -14.972 1.00 26.75 ? 41  LYS B CE  1 
ATOM   2560 N NZ  . LYS B 2 42  ? -33.157 -21.801 -15.638 1.00 27.70 ? 41  LYS B NZ  1 
ATOM   2561 N N   . ASN B 2 43  ? -37.877 -26.570 -12.537 1.00 24.49 ? 42  ASN B N   1 
ATOM   2562 C CA  . ASN B 2 43  ? -38.982 -27.024 -13.383 1.00 24.89 ? 42  ASN B CA  1 
ATOM   2563 C C   . ASN B 2 43  ? -38.992 -28.547 -13.497 1.00 29.84 ? 42  ASN B C   1 
ATOM   2564 O O   . ASN B 2 43  ? -39.268 -29.106 -14.559 1.00 27.80 ? 42  ASN B O   1 
ATOM   2565 C CB  . ASN B 2 43  ? -38.891 -26.368 -14.759 1.00 23.25 ? 42  ASN B CB  1 
ATOM   2566 C CG  . ASN B 2 43  ? -39.083 -24.875 -14.686 1.00 23.92 ? 42  ASN B CG  1 
ATOM   2567 O OD1 . ASN B 2 43  ? -39.848 -24.388 -13.860 1.00 24.32 ? 42  ASN B OD1 1 
ATOM   2568 N ND2 . ASN B 2 43  ? -38.343 -24.135 -15.503 1.00 27.68 ? 42  ASN B ND2 1 
ATOM   2569 N N   . GLY B 2 44  ? -38.645 -29.221 -12.395 1.00 27.38 ? 43  GLY B N   1 
ATOM   2570 C CA  . GLY B 2 44  ? -38.617 -30.667 -12.329 1.00 27.75 ? 43  GLY B CA  1 
ATOM   2571 C C   . GLY B 2 44  ? -37.308 -31.324 -12.727 1.00 27.87 ? 43  GLY B C   1 
ATOM   2572 O O   . GLY B 2 44  ? -37.159 -32.538 -12.530 1.00 33.52 ? 43  GLY B O   1 
ATOM   2573 N N   . GLU B 2 45  ? -36.351 -30.579 -13.269 1.00 27.15 ? 44  GLU B N   1 
ATOM   2574 C CA  . GLU B 2 45  ? -35.129 -31.152 -13.815 1.00 28.23 ? 44  GLU B CA  1 
ATOM   2575 C C   . GLU B 2 45  ? -33.931 -30.836 -12.924 1.00 24.08 ? 44  GLU B C   1 
ATOM   2576 O O   . GLU B 2 45  ? -33.793 -29.716 -12.423 1.00 22.88 ? 44  GLU B O   1 
ATOM   2577 C CB  . GLU B 2 45  ? -34.896 -30.620 -15.224 1.00 30.80 ? 44  GLU B CB  1 
ATOM   2578 C CG  . GLU B 2 45  ? -35.894 -31.171 -16.231 1.00 39.13 ? 44  GLU B CG  1 
ATOM   2579 C CD  . GLU B 2 45  ? -35.727 -30.551 -17.602 1.00 47.37 ? 44  GLU B CD  1 
ATOM   2580 O OE1 . GLU B 2 45  ? -36.738 -30.053 -18.149 1.00 48.86 ? 44  GLU B OE1 1 
ATOM   2581 O OE2 . GLU B 2 45  ? -34.582 -30.535 -18.114 1.00 55.69 ? 44  GLU B OE2 1 
ATOM   2582 N N   . ARG B 2 46  ? -33.054 -31.819 -12.746 1.00 22.71 ? 45  ARG B N   1 
ATOM   2583 C CA  . ARG B 2 46  ? -31.938 -31.654 -11.824 1.00 24.37 ? 45  ARG B CA  1 
ATOM   2584 C C   . ARG B 2 46  ? -30.964 -30.602 -12.353 1.00 27.48 ? 45  ARG B C   1 
ATOM   2585 O O   . ARG B 2 46  ? -30.527 -30.672 -13.505 1.00 27.98 ? 45  ARG B O   1 
ATOM   2586 C CB  . ARG B 2 46  ? -31.213 -32.982 -11.625 1.00 25.20 ? 45  ARG B CB  1 
ATOM   2587 C CG  . ARG B 2 46  ? -29.815 -32.791 -11.110 1.00 31.36 ? 45  ARG B CG  1 
ATOM   2588 C CD  . ARG B 2 46  ? -29.164 -34.090 -10.687 1.00 35.64 ? 45  ARG B CD  1 
ATOM   2589 N NE  . ARG B 2 46  ? -29.574 -35.200 -11.535 1.00 37.57 ? 45  ARG B NE  1 
ATOM   2590 C CZ  . ARG B 2 46  ? -28.813 -36.260 -11.770 1.00 42.77 ? 45  ARG B CZ  1 
ATOM   2591 N NH1 . ARG B 2 46  ? -27.624 -36.393 -11.205 1.00 42.98 ? 45  ARG B NH1 1 
ATOM   2592 N NH2 . ARG B 2 46  ? -29.242 -37.194 -12.615 1.00 41.32 ? 45  ARG B NH2 1 
ATOM   2593 N N   . ILE B 2 47  ? -30.637 -29.614 -11.514 1.00 22.82 ? 46  ILE B N   1 
ATOM   2594 C CA  . ILE B 2 47  ? -29.610 -28.631 -11.847 1.00 22.40 ? 46  ILE B CA  1 
ATOM   2595 C C   . ILE B 2 47  ? -28.237 -29.283 -11.753 1.00 23.80 ? 46  ILE B C   1 
ATOM   2596 O O   . ILE B 2 47  ? -27.938 -29.997 -10.789 1.00 20.90 ? 46  ILE B O   1 
ATOM   2597 C CB  . ILE B 2 47  ? -29.717 -27.420 -10.905 1.00 20.21 ? 46  ILE B CB  1 
ATOM   2598 C CG1 . ILE B 2 47  ? -31.137 -26.863 -10.930 1.00 21.95 ? 46  ILE B CG1 1 
ATOM   2599 C CG2 . ILE B 2 47  ? -28.640 -26.373 -11.221 1.00 23.13 ? 46  ILE B CG2 1 
ATOM   2600 C CD1 . ILE B 2 47  ? -31.356 -25.682 -10.013 1.00 22.26 ? 46  ILE B CD1 1 
ATOM   2601 N N   . GLU B 2 48  ? -27.382 -29.026 -12.741 1.00 25.05 ? 47  GLU B N   1 
ATOM   2602 C CA  . GLU B 2 48  ? -26.202 -29.870 -12.891 1.00 29.23 ? 47  GLU B CA  1 
ATOM   2603 C C   . GLU B 2 48  ? -25.024 -29.451 -12.027 1.00 31.35 ? 47  GLU B C   1 
ATOM   2604 O O   . GLU B 2 48  ? -24.283 -30.319 -11.555 1.00 34.08 ? 47  GLU B O   1 
ATOM   2605 C CB  . GLU B 2 48  ? -25.766 -29.928 -14.358 1.00 35.73 ? 47  GLU B CB  1 
ATOM   2606 C CG  . GLU B 2 48  ? -26.089 -31.277 -15.006 1.00 47.38 ? 47  GLU B CG  1 
ATOM   2607 C CD  . GLU B 2 48  ? -25.973 -31.258 -16.520 1.00 59.88 ? 47  GLU B CD  1 
ATOM   2608 O OE1 . GLU B 2 48  ? -26.389 -30.251 -17.138 1.00 61.50 ? 47  GLU B OE1 1 
ATOM   2609 O OE2 . GLU B 2 48  ? -25.491 -32.260 -17.094 1.00 61.24 ? 47  GLU B OE2 1 
ATOM   2610 N N   . LYS B 2 49  ? -24.800 -28.159 -11.804 1.00 25.69 ? 48  LYS B N   1 
ATOM   2611 C CA  . LYS B 2 49  ? -23.601 -27.742 -11.065 1.00 30.53 ? 48  LYS B CA  1 
ATOM   2612 C C   . LYS B 2 49  ? -24.043 -27.190 -9.713  1.00 29.09 ? 48  LYS B C   1 
ATOM   2613 O O   . LYS B 2 49  ? -24.196 -25.983 -9.522  1.00 35.69 ? 48  LYS B O   1 
ATOM   2614 C CB  . LYS B 2 49  ? -22.780 -26.737 -11.862 1.00 29.93 ? 48  LYS B CB  1 
ATOM   2615 C CG  . LYS B 2 49  ? -21.922 -27.405 -12.948 1.00 39.06 ? 48  LYS B CG  1 
ATOM   2616 C CD  . LYS B 2 49  ? -20.693 -26.582 -13.299 1.00 41.25 ? 48  LYS B CD  1 
ATOM   2617 C CE  . LYS B 2 49  ? -19.488 -26.963 -12.445 1.00 45.06 ? 48  LYS B CE  1 
ATOM   2618 N NZ  . LYS B 2 49  ? -18.314 -27.368 -13.283 1.00 46.79 ? 48  LYS B NZ  1 
ATOM   2619 N N   . VAL B 2 50  ? -24.283 -28.101 -8.776  1.00 20.20 ? 49  VAL B N   1 
ATOM   2620 C CA  . VAL B 2 50  ? -24.671 -27.752 -7.415  1.00 19.19 ? 49  VAL B CA  1 
ATOM   2621 C C   . VAL B 2 50  ? -23.503 -28.052 -6.490  1.00 20.64 ? 49  VAL B C   1 
ATOM   2622 O O   . VAL B 2 50  ? -22.910 -29.134 -6.552  1.00 19.97 ? 49  VAL B O   1 
ATOM   2623 C CB  . VAL B 2 50  ? -25.932 -28.499 -6.964  1.00 16.44 ? 49  VAL B CB  1 
ATOM   2624 C CG1 . VAL B 2 50  ? -26.295 -28.072 -5.545  1.00 17.01 ? 49  VAL B CG1 1 
ATOM   2625 C CG2 . VAL B 2 50  ? -27.094 -28.187 -7.914  1.00 19.41 ? 49  VAL B CG2 1 
ATOM   2626 N N   . GLU B 2 51  ? -23.176 -27.096 -5.640  1.00 19.87 ? 50  GLU B N   1 
ATOM   2627 C CA  . GLU B 2 51  ? -22.126 -27.257 -4.652  1.00 21.20 ? 50  GLU B CA  1 
ATOM   2628 C C   . GLU B 2 51  ? -22.730 -27.605 -3.298  1.00 20.44 ? 50  GLU B C   1 
ATOM   2629 O O   . GLU B 2 51  ? -23.927 -27.430 -3.061  1.00 17.75 ? 50  GLU B O   1 
ATOM   2630 C CB  . GLU B 2 51  ? -21.302 -25.979 -4.553  1.00 24.65 ? 50  GLU B CB  1 
ATOM   2631 C CG  . GLU B 2 51  ? -20.561 -25.681 -5.834  1.00 29.81 ? 50  GLU B CG  1 
ATOM   2632 C CD  . GLU B 2 51  ? -19.094 -25.462 -5.595  1.00 45.68 ? 50  GLU B CD  1 
ATOM   2633 O OE1 . GLU B 2 51  ? -18.418 -26.405 -5.112  1.00 49.32 ? 50  GLU B OE1 1 
ATOM   2634 O OE2 . GLU B 2 51  ? -18.619 -24.345 -5.889  1.00 57.78 ? 50  GLU B OE2 1 
ATOM   2635 N N   . HIS B 2 52  ? -21.887 -28.115 -2.406  1.00 18.51 ? 51  HIS B N   1 
ATOM   2636 C CA  . HIS B 2 52  ? -22.365 -28.399 -1.068  1.00 16.84 ? 51  HIS B CA  1 
ATOM   2637 C C   . HIS B 2 52  ? -21.228 -28.223 -0.071  1.00 17.28 ? 51  HIS B C   1 
ATOM   2638 O O   . HIS B 2 52  ? -20.043 -28.276 -0.417  1.00 14.89 ? 51  HIS B O   1 
ATOM   2639 C CB  . HIS B 2 52  ? -22.988 -29.801 -0.959  1.00 17.64 ? 51  HIS B CB  1 
ATOM   2640 C CG  . HIS B 2 52  ? -22.004 -30.919 -1.109  1.00 21.65 ? 51  HIS B CG  1 
ATOM   2641 N ND1 . HIS B 2 52  ? -21.238 -31.382 -0.058  1.00 22.01 ? 51  HIS B ND1 1 
ATOM   2642 C CD2 . HIS B 2 52  ? -21.689 -31.696 -2.175  1.00 25.87 ? 51  HIS B CD2 1 
ATOM   2643 C CE1 . HIS B 2 52  ? -20.467 -32.370 -0.479  1.00 25.25 ? 51  HIS B CE1 1 
ATOM   2644 N NE2 . HIS B 2 52  ? -20.722 -32.582 -1.759  1.00 31.90 ? 51  HIS B NE2 1 
ATOM   2645 N N   . SER B 2 53  ? -21.620 -27.955 1.168   1.00 12.84 ? 52  SER B N   1 
ATOM   2646 C CA  . SER B 2 53  ? -20.686 -27.726 2.257   1.00 11.00 ? 52  SER B CA  1 
ATOM   2647 C C   . SER B 2 53  ? -20.066 -29.044 2.704   1.00 13.16 ? 52  SER B C   1 
ATOM   2648 O O   . SER B 2 53  ? -20.507 -30.132 2.335   1.00 13.77 ? 52  SER B O   1 
ATOM   2649 C CB  . SER B 2 53  ? -21.416 -27.028 3.403   1.00 12.71 ? 52  SER B CB  1 
ATOM   2650 O OG  . SER B 2 53  ? -22.374 -27.926 3.957   1.00 14.56 ? 52  SER B OG  1 
ATOM   2651 N N   . ASP B 2 54  ? -19.005 -28.947 3.503   1.00 15.88 ? 53  ASP B N   1 
ATOM   2652 C CA  . ASP B 2 54  ? -18.374 -30.146 4.031   1.00 14.45 ? 53  ASP B CA  1 
ATOM   2653 C C   . ASP B 2 54  ? -19.205 -30.738 5.165   1.00 12.50 ? 53  ASP B C   1 
ATOM   2654 O O   . ASP B 2 54  ? -19.708 -30.018 6.022   1.00 12.12 ? 53  ASP B O   1 
ATOM   2655 C CB  . ASP B 2 54  ? -16.973 -29.815 4.529   1.00 15.43 ? 53  ASP B CB  1 
ATOM   2656 C CG  . ASP B 2 54  ? -16.177 -29.051 3.498   1.00 20.44 ? 53  ASP B CG  1 
ATOM   2657 O OD1 . ASP B 2 54  ? -16.085 -29.551 2.356   1.00 21.00 ? 53  ASP B OD1 1 
ATOM   2658 O OD2 . ASP B 2 54  ? -15.675 -27.948 3.808   1.00 19.72 ? 53  ASP B OD2 1 
ATOM   2659 N N   . LEU B 2 55  ? -19.309 -32.060 5.183   1.00 12.56 ? 54  LEU B N   1 
ATOM   2660 C CA  . LEU B 2 55  ? -20.128 -32.749 6.170   1.00 13.18 ? 54  LEU B CA  1 
ATOM   2661 C C   . LEU B 2 55  ? -19.737 -32.368 7.590   1.00 14.02 ? 54  LEU B C   1 
ATOM   2662 O O   . LEU B 2 55  ? -18.565 -32.434 7.976   1.00 14.39 ? 54  LEU B O   1 
ATOM   2663 C CB  . LEU B 2 55  ? -19.993 -34.255 5.982   1.00 14.42 ? 54  LEU B CB  1 
ATOM   2664 C CG  . LEU B 2 55  ? -20.899 -35.096 6.867   1.00 14.78 ? 54  LEU B CG  1 
ATOM   2665 C CD1 . LEU B 2 55  ? -22.378 -34.907 6.465   1.00 16.78 ? 54  LEU B CD1 1 
ATOM   2666 C CD2 . LEU B 2 55  ? -20.476 -36.567 6.792   1.00 16.01 ? 54  LEU B CD2 1 
ATOM   2667 N N   . SER B 2 56  ? -20.729 -31.974 8.370   1.00 12.79 ? 55  SER B N   1 
ATOM   2668 C CA  . SER B 2 56  ? -20.493 -31.601 9.749   1.00 11.54 ? 55  SER B CA  1 
ATOM   2669 C C   . SER B 2 56  ? -21.687 -32.094 10.550  1.00 13.34 ? 55  SER B C   1 
ATOM   2670 O O   . SER B 2 56  ? -22.639 -32.655 9.991   1.00 11.36 ? 55  SER B O   1 
ATOM   2671 C CB  . SER B 2 56  ? -20.287 -30.090 9.867   1.00 16.39 ? 55  SER B CB  1 
ATOM   2672 O OG  . SER B 2 56  ? -19.807 -29.759 11.163  1.00 21.77 ? 55  SER B OG  1 
ATOM   2673 N N   . PHE B 2 57  ? -21.657 -31.879 11.857  1.00 11.52 ? 56  PHE B N   1 
ATOM   2674 C CA  . PHE B 2 57  ? -22.747 -32.377 12.684  1.00 10.59 ? 56  PHE B CA  1 
ATOM   2675 C C   . PHE B 2 57  ? -22.908 -31.503 13.914  1.00 13.40 ? 56  PHE B C   1 
ATOM   2676 O O   . PHE B 2 57  ? -22.015 -30.733 14.284  1.00 13.50 ? 56  PHE B O   1 
ATOM   2677 C CB  . PHE B 2 57  ? -22.552 -33.862 13.051  1.00 8.61  ? 56  PHE B CB  1 
ATOM   2678 C CG  . PHE B 2 57  ? -21.222 -34.194 13.701  1.00 14.54 ? 56  PHE B CG  1 
ATOM   2679 C CD1 . PHE B 2 57  ? -21.041 -34.054 15.075  1.00 13.23 ? 56  PHE B CD1 1 
ATOM   2680 C CD2 . PHE B 2 57  ? -20.171 -34.697 12.939  1.00 11.47 ? 56  PHE B CD2 1 
ATOM   2681 C CE1 . PHE B 2 57  ? -19.827 -34.386 15.678  1.00 10.79 ? 56  PHE B CE1 1 
ATOM   2682 C CE2 . PHE B 2 57  ? -18.955 -35.049 13.535  1.00 12.25 ? 56  PHE B CE2 1 
ATOM   2683 C CZ  . PHE B 2 57  ? -18.787 -34.896 14.901  1.00 9.67  ? 56  PHE B CZ  1 
ATOM   2684 N N   . SER B 2 58  ? -24.066 -31.656 14.558  1.00 15.43 ? 57  SER B N   1 
ATOM   2685 C CA  . SER B 2 58  ? -24.499 -30.833 15.675  1.00 15.51 ? 57  SER B CA  1 
ATOM   2686 C C   . SER B 2 58  ? -24.193 -31.526 16.987  1.00 18.18 ? 57  SER B C   1 
ATOM   2687 O O   . SER B 2 58  ? -23.649 -32.629 17.027  1.00 15.06 ? 57  SER B O   1 
ATOM   2688 C CB  . SER B 2 58  ? -25.999 -30.546 15.589  1.00 17.85 ? 57  SER B CB  1 
ATOM   2689 O OG  . SER B 2 58  ? -26.387 -30.248 14.274  1.00 18.75 ? 57  SER B OG  1 
ATOM   2690 N N   . LYS B 2 59  ? -24.601 -30.885 18.085  1.00 21.63 ? 58  LYS B N   1 
ATOM   2691 C CA  . LYS B 2 59  ? -24.234 -31.418 19.395  1.00 27.25 ? 58  LYS B CA  1 
ATOM   2692 C C   . LYS B 2 59  ? -24.836 -32.792 19.626  1.00 24.69 ? 58  LYS B C   1 
ATOM   2693 O O   . LYS B 2 59  ? -24.192 -33.644 20.250  1.00 22.08 ? 58  LYS B O   1 
ATOM   2694 C CB  . LYS B 2 59  ? -24.643 -30.463 20.519  1.00 29.53 ? 58  LYS B CB  1 
ATOM   2695 C CG  . LYS B 2 59  ? -23.500 -29.533 20.938  1.00 39.34 ? 58  LYS B CG  1 
ATOM   2696 C CD  . LYS B 2 59  ? -22.304 -30.319 21.542  1.00 42.59 ? 58  LYS B CD  1 
ATOM   2697 C CE  . LYS B 2 59  ? -22.645 -31.097 22.825  1.00 37.05 ? 58  LYS B CE  1 
ATOM   2698 N NZ  . LYS B 2 59  ? -21.410 -31.613 23.540  1.00 32.89 ? 58  LYS B NZ  1 
ATOM   2699 N N   . ASP B 2 60  ? -26.033 -33.050 19.090  1.00 16.57 ? 59  ASP B N   1 
ATOM   2700 C CA  . ASP B 2 60  ? -26.658 -34.356 19.263  1.00 18.76 ? 59  ASP B CA  1 
ATOM   2701 C C   . ASP B 2 60  ? -26.141 -35.401 18.294  1.00 16.18 ? 59  ASP B C   1 
ATOM   2702 O O   . ASP B 2 60  ? -26.724 -36.495 18.226  1.00 16.64 ? 59  ASP B O   1 
ATOM   2703 C CB  . ASP B 2 60  ? -28.191 -34.270 19.145  1.00 20.48 ? 59  ASP B CB  1 
ATOM   2704 C CG  . ASP B 2 60  ? -28.666 -33.778 17.782  1.00 26.49 ? 59  ASP B CG  1 
ATOM   2705 O OD1 . ASP B 2 60  ? -27.840 -33.689 16.840  1.00 19.80 ? 59  ASP B OD1 1 
ATOM   2706 O OD2 . ASP B 2 60  ? -29.859 -33.367 17.679  1.00 23.82 ? 59  ASP B OD2 1 
ATOM   2707 N N   . TRP B 2 61  ? -25.083 -35.086 17.541  1.00 14.39 ? 60  TRP B N   1 
ATOM   2708 C CA  . TRP B 2 61  ? -24.419 -35.934 16.555  1.00 13.71 ? 60  TRP B CA  1 
ATOM   2709 C C   . TRP B 2 61  ? -25.159 -36.031 15.214  1.00 15.24 ? 60  TRP B C   1 
ATOM   2710 O O   . TRP B 2 61  ? -24.662 -36.735 14.310  1.00 13.73 ? 60  TRP B O   1 
ATOM   2711 C CB  . TRP B 2 61  ? -24.161 -37.360 17.068  1.00 12.38 ? 60  TRP B CB  1 
ATOM   2712 C CG  . TRP B 2 61  ? -23.413 -37.415 18.392  1.00 17.23 ? 60  TRP B CG  1 
ATOM   2713 C CD1 . TRP B 2 61  ? -23.944 -37.630 19.640  1.00 16.98 ? 60  TRP B CD1 1 
ATOM   2714 C CD2 . TRP B 2 61  ? -22.008 -37.218 18.582  1.00 12.64 ? 60  TRP B CD2 1 
ATOM   2715 N NE1 . TRP B 2 61  ? -22.940 -37.606 20.590  1.00 17.80 ? 60  TRP B NE1 1 
ATOM   2716 C CE2 . TRP B 2 61  ? -21.744 -37.363 19.963  1.00 14.16 ? 60  TRP B CE2 1 
ATOM   2717 C CE3 . TRP B 2 61  ? -20.939 -36.978 17.713  1.00 11.23 ? 60  TRP B CE3 1 
ATOM   2718 C CZ2 . TRP B 2 61  ? -20.463 -37.244 20.497  1.00 13.60 ? 60  TRP B CZ2 1 
ATOM   2719 C CZ3 . TRP B 2 61  ? -19.652 -36.858 18.258  1.00 11.71 ? 60  TRP B CZ3 1 
ATOM   2720 C CH2 . TRP B 2 61  ? -19.434 -36.996 19.629  1.00 10.19 ? 60  TRP B CH2 1 
ATOM   2721 N N   . SER B 2 62  ? -26.290 -35.357 15.024  1.00 14.30 ? 61  SER B N   1 
ATOM   2722 C CA  . SER B 2 62  ? -26.967 -35.473 13.735  1.00 12.31 ? 61  SER B CA  1 
ATOM   2723 C C   . SER B 2 62  ? -26.268 -34.579 12.714  1.00 11.02 ? 61  SER B C   1 
ATOM   2724 O O   . SER B 2 62  ? -25.726 -33.522 13.056  1.00 11.20 ? 61  SER B O   1 
ATOM   2725 C CB  . SER B 2 62  ? -28.435 -35.066 13.823  1.00 14.38 ? 61  SER B CB  1 
ATOM   2726 O OG  . SER B 2 62  ? -28.582 -33.806 14.426  1.00 18.74 ? 61  SER B OG  1 
ATOM   2727 N N   . PHE B 2 63  ? -26.285 -35.007 11.453  1.00 11.03 ? 62  PHE B N   1 
ATOM   2728 C CA  . PHE B 2 63  ? -25.547 -34.337 10.390  1.00 11.20 ? 62  PHE B CA  1 
ATOM   2729 C C   . PHE B 2 63  ? -26.329 -33.165 9.807   1.00 14.51 ? 62  PHE B C   1 
ATOM   2730 O O   . PHE B 2 63  ? -27.559 -33.105 9.886   1.00 13.10 ? 62  PHE B O   1 
ATOM   2731 C CB  . PHE B 2 63  ? -25.203 -35.327 9.276   1.00 12.89 ? 62  PHE B CB  1 
ATOM   2732 C CG  . PHE B 2 63  ? -24.320 -36.423 9.730   1.00 11.88 ? 62  PHE B CG  1 
ATOM   2733 C CD1 . PHE B 2 63  ? -22.954 -36.203 9.903   1.00 13.07 ? 62  PHE B CD1 1 
ATOM   2734 C CD2 . PHE B 2 63  ? -24.853 -37.651 10.092  1.00 14.03 ? 62  PHE B CD2 1 
ATOM   2735 C CE1 . PHE B 2 63  ? -22.124 -37.209 10.349  1.00 10.51 ? 62  PHE B CE1 1 
ATOM   2736 C CE2 . PHE B 2 63  ? -24.028 -38.669 10.555  1.00 16.69 ? 62  PHE B CE2 1 
ATOM   2737 C CZ  . PHE B 2 63  ? -22.651 -38.440 10.688  1.00 14.00 ? 62  PHE B CZ  1 
ATOM   2738 N N   . TYR B 2 64  ? -25.594 -32.218 9.211   1.00 11.78 ? 63  TYR B N   1 
ATOM   2739 C CA  . TYR B 2 64  ? -26.214 -31.180 8.395   1.00 12.46 ? 63  TYR B CA  1 
ATOM   2740 C C   . TYR B 2 64  ? -25.320 -30.884 7.197   1.00 14.40 ? 63  TYR B C   1 
ATOM   2741 O O   . TYR B 2 64  ? -24.095 -31.023 7.266   1.00 12.66 ? 63  TYR B O   1 
ATOM   2742 C CB  . TYR B 2 64  ? -26.486 -29.886 9.186   1.00 13.49 ? 63  TYR B CB  1 
ATOM   2743 C CG  . TYR B 2 64  ? -25.260 -29.251 9.807   1.00 14.07 ? 63  TYR B CG  1 
ATOM   2744 C CD1 . TYR B 2 64  ? -24.501 -28.310 9.112   1.00 11.95 ? 63  TYR B CD1 1 
ATOM   2745 C CD2 . TYR B 2 64  ? -24.866 -29.588 11.099  1.00 15.94 ? 63  TYR B CD2 1 
ATOM   2746 C CE1 . TYR B 2 64  ? -23.352 -27.735 9.693   1.00 14.88 ? 63  TYR B CE1 1 
ATOM   2747 C CE2 . TYR B 2 64  ? -23.726 -29.020 11.676  1.00 16.11 ? 63  TYR B CE2 1 
ATOM   2748 C CZ  . TYR B 2 64  ? -22.986 -28.096 10.975  1.00 17.82 ? 63  TYR B CZ  1 
ATOM   2749 O OH  . TYR B 2 64  ? -21.868 -27.547 11.579  1.00 19.46 ? 63  TYR B OH  1 
ATOM   2750 N N   . LEU B 2 65  ? -25.957 -30.482 6.099   1.00 12.68 ? 64  LEU B N   1 
ATOM   2751 C CA  . LEU B 2 65  ? -25.302 -30.091 4.859   1.00 13.09 ? 64  LEU B CA  1 
ATOM   2752 C C   . LEU B 2 65  ? -26.081 -28.965 4.194   1.00 15.56 ? 64  LEU B C   1 
ATOM   2753 O O   . LEU B 2 65  ? -27.319 -28.927 4.235   1.00 12.33 ? 64  LEU B O   1 
ATOM   2754 C CB  . LEU B 2 65  ? -25.204 -31.233 3.841   1.00 12.97 ? 64  LEU B CB  1 
ATOM   2755 C CG  . LEU B 2 65  ? -24.392 -32.475 4.150   1.00 15.96 ? 64  LEU B CG  1 
ATOM   2756 C CD1 . LEU B 2 65  ? -24.871 -33.576 3.234   1.00 14.52 ? 64  LEU B CD1 1 
ATOM   2757 C CD2 . LEU B 2 65  ? -22.893 -32.206 3.967   1.00 12.96 ? 64  LEU B CD2 1 
ATOM   2758 N N   . LEU B 2 66  ? -25.348 -28.081 3.529   1.00 10.97 ? 65  LEU B N   1 
ATOM   2759 C CA  . LEU B 2 66  ? -25.940 -27.038 2.707   1.00 12.19 ? 65  LEU B CA  1 
ATOM   2760 C C   . LEU B 2 66  ? -25.585 -27.304 1.250   1.00 16.16 ? 65  LEU B C   1 
ATOM   2761 O O   . LEU B 2 66  ? -24.401 -27.360 0.902   1.00 12.81 ? 65  LEU B O   1 
ATOM   2762 C CB  . LEU B 2 66  ? -25.447 -25.657 3.131   1.00 13.12 ? 65  LEU B CB  1 
ATOM   2763 C CG  . LEU B 2 66  ? -25.935 -24.536 2.205   1.00 13.10 ? 65  LEU B CG  1 
ATOM   2764 C CD1 . LEU B 2 66  ? -27.408 -24.314 2.469   1.00 17.08 ? 65  LEU B CD1 1 
ATOM   2765 C CD2 . LEU B 2 66  ? -25.126 -23.269 2.448   1.00 16.05 ? 65  LEU B CD2 1 
ATOM   2766 N N   . TYR B 2 67  ? -26.607 -27.468 0.404   1.00 14.43 ? 66  TYR B N   1 
ATOM   2767 C CA  . TYR B 2 67  ? -26.443 -27.527 -1.046  1.00 14.16 ? 66  TYR B CA  1 
ATOM   2768 C C   . TYR B 2 67  ? -26.874 -26.193 -1.628  1.00 14.09 ? 66  TYR B C   1 
ATOM   2769 O O   . TYR B 2 67  ? -27.838 -25.600 -1.150  1.00 13.49 ? 66  TYR B O   1 
ATOM   2770 C CB  . TYR B 2 67  ? -27.283 -28.646 -1.670  1.00 15.98 ? 66  TYR B CB  1 
ATOM   2771 C CG  . TYR B 2 67  ? -26.785 -30.026 -1.332  1.00 16.63 ? 66  TYR B CG  1 
ATOM   2772 C CD1 . TYR B 2 67  ? -26.950 -30.554 -0.055  1.00 17.45 ? 66  TYR B CD1 1 
ATOM   2773 C CD2 . TYR B 2 67  ? -26.104 -30.783 -2.277  1.00 15.95 ? 66  TYR B CD2 1 
ATOM   2774 C CE1 . TYR B 2 67  ? -26.470 -31.811 0.265   1.00 18.77 ? 66  TYR B CE1 1 
ATOM   2775 C CE2 . TYR B 2 67  ? -25.612 -32.035 -1.963  1.00 19.36 ? 66  TYR B CE2 1 
ATOM   2776 C CZ  . TYR B 2 67  ? -25.806 -32.546 -0.694  1.00 19.56 ? 66  TYR B CZ  1 
ATOM   2777 O OH  . TYR B 2 67  ? -25.336 -33.804 -0.380  1.00 22.36 ? 66  TYR B OH  1 
ATOM   2778 N N   . TYR B 2 68  ? -26.151 -25.704 -2.638  1.00 10.93 ? 67  TYR B N   1 
ATOM   2779 C CA  . TYR B 2 68  ? -26.475 -24.362 -3.105  1.00 14.23 ? 67  TYR B CA  1 
ATOM   2780 C C   . TYR B 2 68  ? -26.022 -24.168 -4.542  1.00 17.49 ? 67  TYR B C   1 
ATOM   2781 O O   . TYR B 2 68  ? -25.105 -24.840 -5.019  1.00 16.10 ? 67  TYR B O   1 
ATOM   2782 C CB  . TYR B 2 68  ? -25.833 -23.288 -2.217  1.00 16.47 ? 67  TYR B CB  1 
ATOM   2783 C CG  . TYR B 2 68  ? -24.330 -23.414 -2.117  1.00 19.24 ? 67  TYR B CG  1 
ATOM   2784 C CD1 . TYR B 2 68  ? -23.742 -24.279 -1.196  1.00 20.05 ? 67  TYR B CD1 1 
ATOM   2785 C CD2 . TYR B 2 68  ? -23.495 -22.686 -2.959  1.00 20.81 ? 67  TYR B CD2 1 
ATOM   2786 C CE1 . TYR B 2 68  ? -22.355 -24.399 -1.106  1.00 20.25 ? 67  TYR B CE1 1 
ATOM   2787 C CE2 . TYR B 2 68  ? -22.105 -22.805 -2.879  1.00 21.03 ? 67  TYR B CE2 1 
ATOM   2788 C CZ  . TYR B 2 68  ? -21.550 -23.664 -1.955  1.00 24.69 ? 67  TYR B CZ  1 
ATOM   2789 O OH  . TYR B 2 68  ? -20.188 -23.790 -1.862  1.00 31.47 ? 67  TYR B OH  1 
ATOM   2790 N N   . THR B 2 69  ? -26.686 -23.237 -5.226  1.00 20.49 ? 68  THR B N   1 
ATOM   2791 C CA  . THR B 2 69  ? -26.261 -22.840 -6.555  1.00 19.08 ? 68  THR B CA  1 
ATOM   2792 C C   . THR B 2 69  ? -26.661 -21.390 -6.794  1.00 18.63 ? 68  THR B C   1 
ATOM   2793 O O   . THR B 2 69  ? -27.631 -20.892 -6.217  1.00 17.91 ? 68  THR B O   1 
ATOM   2794 C CB  . THR B 2 69  ? -26.861 -23.735 -7.648  1.00 22.41 ? 68  THR B CB  1 
ATOM   2795 O OG1 . THR B 2 69  ? -26.357 -23.300 -8.914  1.00 29.92 ? 68  THR B OG1 1 
ATOM   2796 C CG2 . THR B 2 69  ? -28.375 -23.607 -7.678  1.00 20.22 ? 68  THR B CG2 1 
ATOM   2797 N N   . GLU B 2 70  ? -25.885 -20.706 -7.627  1.00 19.26 ? 69  GLU B N   1 
ATOM   2798 C CA  . GLU B 2 70  ? -26.261 -19.368 -8.049  1.00 23.14 ? 69  GLU B CA  1 
ATOM   2799 C C   . GLU B 2 70  ? -27.446 -19.458 -9.010  1.00 23.37 ? 69  GLU B C   1 
ATOM   2800 O O   . GLU B 2 70  ? -27.566 -20.403 -9.793  1.00 23.80 ? 69  GLU B O   1 
ATOM   2801 C CB  . GLU B 2 70  ? -25.068 -18.670 -8.709  1.00 26.98 ? 69  GLU B CB  1 
ATOM   2802 C CG  . GLU B 2 70  ? -25.335 -17.227 -9.166  1.00 35.74 ? 69  GLU B CG  1 
ATOM   2803 C CD  . GLU B 2 70  ? -25.891 -17.118 -10.589 1.00 44.99 ? 69  GLU B CD  1 
ATOM   2804 O OE1 . GLU B 2 70  ? -26.877 -16.363 -10.798 1.00 45.31 ? 69  GLU B OE1 1 
ATOM   2805 O OE2 . GLU B 2 70  ? -25.334 -17.773 -11.506 1.00 54.85 ? 69  GLU B OE2 1 
ATOM   2806 N N   . PHE B 2 71  ? -28.349 -18.484 -8.936  1.00 24.98 ? 70  PHE B N   1 
ATOM   2807 C CA  . PHE B 2 71  ? -29.474 -18.499 -9.868  1.00 22.72 ? 70  PHE B CA  1 
ATOM   2808 C C   . PHE B 2 71  ? -30.111 -17.120 -9.934  1.00 23.70 ? 70  PHE B C   1 
ATOM   2809 O O   . PHE B 2 71  ? -29.868 -16.260 -9.083  1.00 22.27 ? 70  PHE B O   1 
ATOM   2810 C CB  . PHE B 2 71  ? -30.503 -19.579 -9.487  1.00 20.50 ? 70  PHE B CB  1 
ATOM   2811 C CG  . PHE B 2 71  ? -31.509 -19.147 -8.446  1.00 20.59 ? 70  PHE B CG  1 
ATOM   2812 C CD1 . PHE B 2 71  ? -31.096 -18.655 -7.217  1.00 16.67 ? 70  PHE B CD1 1 
ATOM   2813 C CD2 . PHE B 2 71  ? -32.861 -19.282 -8.680  1.00 19.47 ? 70  PHE B CD2 1 
ATOM   2814 C CE1 . PHE B 2 71  ? -32.018 -18.274 -6.263  1.00 17.30 ? 70  PHE B CE1 1 
ATOM   2815 C CE2 . PHE B 2 71  ? -33.788 -18.903 -7.732  1.00 22.07 ? 70  PHE B CE2 1 
ATOM   2816 C CZ  . PHE B 2 71  ? -33.364 -18.406 -6.517  1.00 22.82 ? 70  PHE B CZ  1 
ATOM   2817 N N   . THR B 2 72  ? -30.913 -16.911 -10.973 1.00 24.89 ? 71  THR B N   1 
ATOM   2818 C CA  . THR B 2 72  ? -31.679 -15.673 -11.105 1.00 25.15 ? 71  THR B CA  1 
ATOM   2819 C C   . THR B 2 72  ? -33.137 -16.058 -11.198 1.00 26.23 ? 71  THR B C   1 
ATOM   2820 O O   . THR B 2 72  ? -33.562 -16.636 -12.217 1.00 27.61 ? 71  THR B O   1 
ATOM   2821 C CB  . THR B 2 72  ? -31.269 -14.849 -12.326 1.00 28.17 ? 71  THR B CB  1 
ATOM   2822 O OG1 . THR B 2 72  ? -31.399 -15.654 -13.498 1.00 43.96 ? 71  THR B OG1 1 
ATOM   2823 C CG2 . THR B 2 72  ? -29.834 -14.391 -12.202 1.00 25.20 ? 71  THR B CG2 1 
ATOM   2824 N N   . PRO B 2 73  ? -33.927 -15.785 -10.170 1.00 22.99 ? 72  PRO B N   1 
ATOM   2825 C CA  . PRO B 2 73  ? -35.345 -16.121 -10.233 1.00 28.05 ? 72  PRO B CA  1 
ATOM   2826 C C   . PRO B 2 73  ? -36.057 -15.318 -11.309 1.00 25.26 ? 72  PRO B C   1 
ATOM   2827 O O   . PRO B 2 73  ? -35.729 -14.164 -11.589 1.00 26.47 ? 72  PRO B O   1 
ATOM   2828 C CB  . PRO B 2 73  ? -35.866 -15.776 -8.833  1.00 28.11 ? 72  PRO B CB  1 
ATOM   2829 C CG  . PRO B 2 73  ? -34.787 -14.977 -8.167  1.00 25.90 ? 72  PRO B CG  1 
ATOM   2830 C CD  . PRO B 2 73  ? -33.575 -14.938 -9.021  1.00 25.03 ? 72  PRO B CD  1 
ATOM   2831 N N   . THR B 2 74  ? -37.024 -15.972 -11.930 1.00 28.82 ? 73  THR B N   1 
ATOM   2832 C CA  . THR B 2 74  ? -37.934 -15.375 -12.888 1.00 26.79 ? 73  THR B CA  1 
ATOM   2833 C C   . THR B 2 74  ? -39.348 -15.727 -12.465 1.00 33.39 ? 73  THR B C   1 
ATOM   2834 O O   . THR B 2 74  ? -39.563 -16.555 -11.574 1.00 29.25 ? 73  THR B O   1 
ATOM   2835 C CB  . THR B 2 74  ? -37.646 -15.858 -14.314 1.00 26.66 ? 73  THR B CB  1 
ATOM   2836 O OG1 . THR B 2 74  ? -38.193 -17.168 -14.480 1.00 33.60 ? 73  THR B OG1 1 
ATOM   2837 C CG2 . THR B 2 74  ? -36.148 -15.873 -14.619 1.00 28.34 ? 73  THR B CG2 1 
ATOM   2838 N N   . GLU B 2 75  ? -40.324 -15.088 -13.113 1.00 31.57 ? 74  GLU B N   1 
ATOM   2839 C CA  . GLU B 2 75  ? -41.706 -15.255 -12.683 1.00 30.68 ? 74  GLU B CA  1 
ATOM   2840 C C   . GLU B 2 75  ? -42.179 -16.699 -12.840 1.00 32.29 ? 74  GLU B C   1 
ATOM   2841 O O   . GLU B 2 75  ? -42.912 -17.210 -11.986 1.00 33.84 ? 74  GLU B O   1 
ATOM   2842 C CB  . GLU B 2 75  ? -42.620 -14.300 -13.451 1.00 33.70 ? 74  GLU B CB  1 
ATOM   2843 C CG  . GLU B 2 75  ? -44.081 -14.343 -12.976 1.00 43.51 ? 74  GLU B CG  1 
ATOM   2844 C CD  . GLU B 2 75  ? -44.970 -13.266 -13.613 1.00 48.62 ? 74  GLU B CD  1 
ATOM   2845 O OE1 . GLU B 2 75  ? -44.438 -12.348 -14.281 1.00 52.15 ? 74  GLU B OE1 1 
ATOM   2846 O OE2 . GLU B 2 75  ? -46.207 -13.343 -13.440 1.00 47.57 ? 74  GLU B OE2 1 
ATOM   2847 N N   . LYS B 2 76  ? -41.766 -17.386 -13.905 1.00 34.61 ? 75  LYS B N   1 
ATOM   2848 C CA  . LYS B 2 76  ? -42.390 -18.666 -14.231 1.00 42.41 ? 75  LYS B CA  1 
ATOM   2849 C C   . LYS B 2 76  ? -41.459 -19.867 -14.071 1.00 35.87 ? 75  LYS B C   1 
ATOM   2850 O O   . LYS B 2 76  ? -41.772 -20.959 -14.555 1.00 40.21 ? 75  LYS B O   1 
ATOM   2851 C CB  . LYS B 2 76  ? -42.988 -18.612 -15.638 1.00 46.07 ? 75  LYS B CB  1 
ATOM   2852 C CG  . LYS B 2 76  ? -43.703 -17.277 -15.890 1.00 51.80 ? 75  LYS B CG  1 
ATOM   2853 C CD  . LYS B 2 76  ? -45.169 -17.448 -16.292 1.00 50.10 ? 75  LYS B CD  1 
ATOM   2854 C CE  . LYS B 2 76  ? -45.815 -16.093 -16.569 1.00 51.32 ? 75  LYS B CE  1 
ATOM   2855 N NZ  . LYS B 2 76  ? -47.276 -16.065 -16.233 1.00 59.82 ? 75  LYS B NZ  1 
ATOM   2856 N N   . ASP B 2 77  ? -40.351 -19.710 -13.364 1.00 34.18 ? 76  ASP B N   1 
ATOM   2857 C CA  . ASP B 2 77  ? -39.454 -20.818 -13.070 1.00 30.92 ? 76  ASP B CA  1 
ATOM   2858 C C   . ASP B 2 77  ? -39.769 -21.345 -11.671 1.00 30.74 ? 76  ASP B C   1 
ATOM   2859 O O   . ASP B 2 77  ? -39.899 -20.559 -10.726 1.00 29.12 ? 76  ASP B O   1 
ATOM   2860 C CB  . ASP B 2 77  ? -38.009 -20.345 -13.172 1.00 30.09 ? 76  ASP B CB  1 
ATOM   2861 C CG  . ASP B 2 77  ? -37.482 -20.407 -14.591 1.00 29.00 ? 76  ASP B CG  1 
ATOM   2862 O OD1 . ASP B 2 77  ? -38.077 -21.116 -15.424 1.00 31.47 ? 76  ASP B OD1 1 
ATOM   2863 O OD2 . ASP B 2 77  ? -36.514 -19.687 -14.883 1.00 32.43 ? 76  ASP B OD2 1 
ATOM   2864 N N   . GLU B 2 78  ? -39.921 -22.665 -11.546 1.00 27.76 ? 77  GLU B N   1 
ATOM   2865 C CA  . GLU B 2 78  ? -40.256 -23.313 -10.280 1.00 26.99 ? 77  GLU B CA  1 
ATOM   2866 C C   . GLU B 2 78  ? -39.045 -24.083 -9.767  1.00 22.68 ? 77  GLU B C   1 
ATOM   2867 O O   . GLU B 2 78  ? -38.449 -24.868 -10.508 1.00 24.93 ? 77  GLU B O   1 
ATOM   2868 C CB  . GLU B 2 78  ? -41.441 -24.270 -10.449 1.00 28.87 ? 77  GLU B CB  1 
ATOM   2869 C CG  . GLU B 2 78  ? -42.652 -23.672 -11.171 1.00 34.51 ? 77  GLU B CG  1 
ATOM   2870 C CD  . GLU B 2 78  ? -43.945 -24.409 -10.848 1.00 47.22 ? 77  GLU B CD  1 
ATOM   2871 O OE1 . GLU B 2 78  ? -43.858 -25.489 -10.220 1.00 49.45 ? 77  GLU B OE1 1 
ATOM   2872 O OE2 . GLU B 2 78  ? -45.039 -23.936 -11.257 1.00 48.46 ? 77  GLU B OE2 1 
ATOM   2873 N N   . TYR B 2 79  ? -38.688 -23.879 -8.508  1.00 22.11 ? 78  TYR B N   1 
ATOM   2874 C CA  . TYR B 2 79  ? -37.525 -24.546 -7.933  1.00 21.04 ? 78  TYR B CA  1 
ATOM   2875 C C   . TYR B 2 79  ? -37.931 -25.447 -6.774  1.00 19.84 ? 78  TYR B C   1 
ATOM   2876 O O   . TYR B 2 79  ? -38.907 -25.175 -6.063  1.00 19.14 ? 78  TYR B O   1 
ATOM   2877 C CB  . TYR B 2 79  ? -36.468 -23.532 -7.465  1.00 18.36 ? 78  TYR B CB  1 
ATOM   2878 C CG  . TYR B 2 79  ? -35.829 -22.787 -8.610  1.00 20.82 ? 78  TYR B CG  1 
ATOM   2879 C CD1 . TYR B 2 79  ? -34.731 -23.318 -9.272  1.00 18.76 ? 78  TYR B CD1 1 
ATOM   2880 C CD2 . TYR B 2 79  ? -36.361 -21.588 -9.076  1.00 23.53 ? 78  TYR B CD2 1 
ATOM   2881 C CE1 . TYR B 2 79  ? -34.142 -22.658 -10.333 1.00 22.05 ? 78  TYR B CE1 1 
ATOM   2882 C CE2 . TYR B 2 79  ? -35.777 -20.919 -10.141 1.00 22.30 ? 78  TYR B CE2 1 
ATOM   2883 C CZ  . TYR B 2 79  ? -34.673 -21.460 -10.761 1.00 24.73 ? 78  TYR B CZ  1 
ATOM   2884 O OH  . TYR B 2 79  ? -34.101 -20.800 -11.814 1.00 25.53 ? 78  TYR B OH  1 
ATOM   2885 N N   . ALA B 2 80  ? -37.176 -26.532 -6.597  1.00 18.95 ? 79  ALA B N   1 
ATOM   2886 C CA  . ALA B 2 80  ? -37.441 -27.484 -5.527  1.00 15.68 ? 79  ALA B CA  1 
ATOM   2887 C C   . ALA B 2 80  ? -36.151 -28.201 -5.131  1.00 17.50 ? 79  ALA B C   1 
ATOM   2888 O O   . ALA B 2 80  ? -35.133 -28.146 -5.828  1.00 18.34 ? 79  ALA B O   1 
ATOM   2889 C CB  . ALA B 2 80  ? -38.507 -28.505 -5.929  1.00 20.05 ? 79  ALA B CB  1 
ATOM   2890 N N   . CYS B 2 81  ? -36.210 -28.876 -3.987  1.00 15.89 ? 80  CYS B N   1 
ATOM   2891 C CA  . CYS B 2 81  ? -35.099 -29.667 -3.472  1.00 16.51 ? 80  CYS B CA  1 
ATOM   2892 C C   . CYS B 2 81  ? -35.557 -31.106 -3.279  1.00 18.77 ? 80  CYS B C   1 
ATOM   2893 O O   . CYS B 2 81  ? -36.583 -31.345 -2.631  1.00 20.11 ? 80  CYS B O   1 
ATOM   2894 C CB  . CYS B 2 81  ? -34.591 -29.097 -2.138  1.00 19.68 ? 80  CYS B CB  1 
ATOM   2895 S SG  . CYS B 2 81  ? -33.221 -30.037 -1.506  1.00 34.29 ? 80  CYS B SG  1 
ATOM   2896 N N   . ARG B 2 82  ? -34.796 -32.064 -3.809  1.00 17.74 ? 81  ARG B N   1 
ATOM   2897 C CA  . ARG B 2 82  ? -35.171 -33.470 -3.711  1.00 16.58 ? 81  ARG B CA  1 
ATOM   2898 C C   . ARG B 2 82  ? -34.162 -34.197 -2.833  1.00 15.85 ? 81  ARG B C   1 
ATOM   2899 O O   . ARG B 2 82  ? -32.969 -34.252 -3.156  1.00 15.88 ? 81  ARG B O   1 
ATOM   2900 C CB  . ARG B 2 82  ? -35.264 -34.124 -5.087  1.00 16.18 ? 81  ARG B CB  1 
ATOM   2901 C CG  . ARG B 2 82  ? -35.455 -35.623 -5.022  1.00 14.90 ? 81  ARG B CG  1 
ATOM   2902 C CD  . ARG B 2 82  ? -35.423 -36.246 -6.403  1.00 17.06 ? 81  ARG B CD  1 
ATOM   2903 N NE  . ARG B 2 82  ? -34.089 -36.207 -6.984  1.00 17.29 ? 81  ARG B NE  1 
ATOM   2904 C CZ  . ARG B 2 82  ? -33.841 -36.302 -8.282  1.00 20.67 ? 81  ARG B CZ  1 
ATOM   2905 N NH1 . ARG B 2 82  ? -34.819 -36.437 -9.162  1.00 20.59 ? 81  ARG B NH1 1 
ATOM   2906 N NH2 . ARG B 2 82  ? -32.582 -36.255 -8.706  1.00 21.54 ? 81  ARG B NH2 1 
ATOM   2907 N N   . VAL B 2 83  ? -34.642 -34.748 -1.727  1.00 13.31 ? 82  VAL B N   1 
ATOM   2908 C CA  . VAL B 2 83  ? -33.787 -35.356 -0.714  1.00 16.10 ? 82  VAL B CA  1 
ATOM   2909 C C   . VAL B 2 83  ? -34.046 -36.850 -0.698  1.00 15.76 ? 82  VAL B C   1 
ATOM   2910 O O   . VAL B 2 83  ? -35.188 -37.289 -0.514  1.00 12.99 ? 82  VAL B O   1 
ATOM   2911 C CB  . VAL B 2 83  ? -34.020 -34.737 0.667   1.00 14.34 ? 82  VAL B CB  1 
ATOM   2912 C CG1 . VAL B 2 83  ? -33.046 -35.337 1.701   1.00 15.06 ? 82  VAL B CG1 1 
ATOM   2913 C CG2 . VAL B 2 83  ? -33.829 -33.236 0.564   1.00 15.48 ? 82  VAL B CG2 1 
ATOM   2914 N N   . ASN B 2 84  ? -32.979 -37.624 -0.880  1.00 14.19 ? 83  ASN B N   1 
ATOM   2915 C CA  . ASN B 2 84  ? -33.034 -39.077 -0.926  1.00 15.81 ? 83  ASN B CA  1 
ATOM   2916 C C   . ASN B 2 84  ? -32.230 -39.607 0.262   1.00 17.27 ? 83  ASN B C   1 
ATOM   2917 O O   . ASN B 2 84  ? -31.030 -39.336 0.374   1.00 13.71 ? 83  ASN B O   1 
ATOM   2918 C CB  . ASN B 2 84  ? -32.511 -39.556 -2.286  1.00 15.03 ? 83  ASN B CB  1 
ATOM   2919 C CG  . ASN B 2 84  ? -32.519 -41.065 -2.447  1.00 18.56 ? 83  ASN B CG  1 
ATOM   2920 O OD1 . ASN B 2 84  ? -33.416 -41.760 -1.955  1.00 16.90 ? 83  ASN B OD1 1 
ATOM   2921 N ND2 . ASN B 2 84  ? -31.590 -41.564 -3.265  1.00 16.80 ? 83  ASN B ND2 1 
ATOM   2922 N N   . HIS B 2 85  ? -32.908 -40.305 1.178   1.00 16.55 ? 84  HIS B N   1 
ATOM   2923 C CA  . HIS B 2 85  ? -32.303 -40.771 2.429   1.00 16.02 ? 84  HIS B CA  1 
ATOM   2924 C C   . HIS B 2 85  ? -32.969 -42.080 2.831   1.00 17.22 ? 84  HIS B C   1 
ATOM   2925 O O   . HIS B 2 85  ? -34.135 -42.318 2.500   1.00 17.78 ? 84  HIS B O   1 
ATOM   2926 C CB  . HIS B 2 85  ? -32.473 -39.745 3.558   1.00 15.99 ? 84  HIS B CB  1 
ATOM   2927 C CG  . HIS B 2 85  ? -31.641 -40.028 4.782   1.00 15.95 ? 84  HIS B CG  1 
ATOM   2928 N ND1 . HIS B 2 85  ? -32.202 -40.375 5.994   1.00 14.04 ? 84  HIS B ND1 1 
ATOM   2929 C CD2 . HIS B 2 85  ? -30.305 -39.963 4.994   1.00 13.64 ? 84  HIS B CD2 1 
ATOM   2930 C CE1 . HIS B 2 85  ? -31.246 -40.537 6.893   1.00 16.50 ? 84  HIS B CE1 1 
ATOM   2931 N NE2 . HIS B 2 85  ? -30.084 -40.298 6.311   1.00 14.09 ? 84  HIS B NE2 1 
ATOM   2932 N N   . VAL B 2 86  ? -32.232 -42.924 3.560   1.00 13.04 ? 85  VAL B N   1 
ATOM   2933 C CA  . VAL B 2 86  ? -32.750 -44.256 3.876   1.00 17.66 ? 85  VAL B CA  1 
ATOM   2934 C C   . VAL B 2 86  ? -34.035 -44.173 4.705   1.00 20.52 ? 85  VAL B C   1 
ATOM   2935 O O   . VAL B 2 86  ? -34.909 -45.047 4.593   1.00 18.11 ? 85  VAL B O   1 
ATOM   2936 C CB  . VAL B 2 86  ? -31.671 -45.096 4.595   1.00 22.52 ? 85  VAL B CB  1 
ATOM   2937 C CG1 . VAL B 2 86  ? -31.099 -44.340 5.794   1.00 20.45 ? 85  VAL B CG1 1 
ATOM   2938 C CG2 . VAL B 2 86  ? -32.217 -46.456 5.005   1.00 24.90 ? 85  VAL B CG2 1 
ATOM   2939 N N   . THR B 2 87  ? -34.196 -43.121 5.522   1.00 15.01 ? 86  THR B N   1 
ATOM   2940 C CA  . THR B 2 87  ? -35.425 -42.953 6.300   1.00 18.09 ? 86  THR B CA  1 
ATOM   2941 C C   . THR B 2 87  ? -36.638 -42.560 5.454   1.00 19.19 ? 86  THR B C   1 
ATOM   2942 O O   . THR B 2 87  ? -37.743 -42.494 6.001   1.00 18.14 ? 86  THR B O   1 
ATOM   2943 C CB  . THR B 2 87  ? -35.262 -41.892 7.393   1.00 19.31 ? 86  THR B CB  1 
ATOM   2944 O OG1 . THR B 2 87  ? -34.989 -40.619 6.789   1.00 18.06 ? 86  THR B OG1 1 
ATOM   2945 C CG2 . THR B 2 87  ? -34.121 -42.261 8.351   1.00 18.98 ? 86  THR B CG2 1 
ATOM   2946 N N   . LEU B 2 88  ? -36.468 -42.265 4.163   1.00 17.55 ? 87  LEU B N   1 
ATOM   2947 C CA  . LEU B 2 88  ? -37.553 -41.801 3.300   1.00 18.50 ? 87  LEU B CA  1 
ATOM   2948 C C   . LEU B 2 88  ? -37.874 -42.899 2.294   1.00 21.35 ? 87  LEU B C   1 
ATOM   2949 O O   . LEU B 2 88  ? -37.040 -43.241 1.454   1.00 20.31 ? 87  LEU B O   1 
ATOM   2950 C CB  . LEU B 2 88  ? -37.177 -40.501 2.595   1.00 17.34 ? 87  LEU B CB  1 
ATOM   2951 C CG  . LEU B 2 88  ? -36.703 -39.352 3.495   1.00 18.48 ? 87  LEU B CG  1 
ATOM   2952 C CD1 . LEU B 2 88  ? -36.322 -38.127 2.673   1.00 19.81 ? 87  LEU B CD1 1 
ATOM   2953 C CD2 . LEU B 2 88  ? -37.842 -38.974 4.432   1.00 22.35 ? 87  LEU B CD2 1 
ATOM   2954 N N   . SER B 2 89  ? -39.087 -43.447 2.389   1.00 20.93 ? 88  SER B N   1 
ATOM   2955 C CA  . SER B 2 89  ? -39.504 -44.508 1.480   1.00 23.56 ? 88  SER B CA  1 
ATOM   2956 C C   . SER B 2 89  ? -39.605 -44.013 0.035   1.00 22.90 ? 88  SER B C   1 
ATOM   2957 O O   . SER B 2 89  ? -39.434 -44.799 -0.904  1.00 21.43 ? 88  SER B O   1 
ATOM   2958 C CB  . SER B 2 89  ? -40.821 -45.103 1.986   1.00 23.14 ? 88  SER B CB  1 
ATOM   2959 O OG  . SER B 2 89  ? -41.887 -44.200 1.814   1.00 32.59 ? 88  SER B OG  1 
ATOM   2960 N N   . GLN B 2 90  ? -39.819 -42.719 -0.167  1.00 17.86 ? 89  GLN B N   1 
ATOM   2961 C CA  . GLN B 2 90  ? -39.611 -42.102 -1.467  1.00 18.38 ? 89  GLN B CA  1 
ATOM   2962 C C   . GLN B 2 90  ? -38.933 -40.746 -1.263  1.00 16.00 ? 89  GLN B C   1 
ATOM   2963 O O   . GLN B 2 90  ? -39.066 -40.155 -0.192  1.00 16.85 ? 89  GLN B O   1 
ATOM   2964 C CB  . GLN B 2 90  ? -40.947 -41.978 -2.223  1.00 17.34 ? 89  GLN B CB  1 
ATOM   2965 C CG  . GLN B 2 90  ? -41.993 -41.065 -1.588  1.00 17.28 ? 89  GLN B CG  1 
ATOM   2966 C CD  . GLN B 2 90  ? -43.115 -40.646 -2.567  1.00 24.41 ? 89  GLN B CD  1 
ATOM   2967 O OE1 . GLN B 2 90  ? -43.143 -41.067 -3.717  1.00 29.51 ? 89  GLN B OE1 1 
ATOM   2968 N NE2 . GLN B 2 90  ? -44.092 -39.906 -2.063  1.00 27.13 ? 89  GLN B NE2 1 
ATOM   2969 N N   . PRO B 2 91  ? -38.131 -40.305 -2.232  1.00 15.82 ? 90  PRO B N   1 
ATOM   2970 C CA  . PRO B 2 91  ? -37.440 -39.014 -2.073  1.00 15.61 ? 90  PRO B CA  1 
ATOM   2971 C C   . PRO B 2 91  ? -38.421 -37.905 -1.720  1.00 17.25 ? 90  PRO B C   1 
ATOM   2972 O O   . PRO B 2 91  ? -39.513 -37.817 -2.284  1.00 15.05 ? 90  PRO B O   1 
ATOM   2973 C CB  . PRO B 2 91  ? -36.812 -38.787 -3.451  1.00 15.84 ? 90  PRO B CB  1 
ATOM   2974 C CG  . PRO B 2 91  ? -36.566 -40.169 -3.990  1.00 15.33 ? 90  PRO B CG  1 
ATOM   2975 C CD  . PRO B 2 91  ? -37.621 -41.075 -3.383  1.00 12.71 ? 90  PRO B CD  1 
ATOM   2976 N N   . LYS B 2 92  ? -38.031 -37.038 -0.788  1.00 14.13 ? 91  LYS B N   1 
ATOM   2977 C CA  . LYS B 2 92  ? -38.905 -35.934 -0.415  1.00 18.64 ? 91  LYS B CA  1 
ATOM   2978 C C   . LYS B 2 92  ? -38.583 -34.730 -1.288  1.00 17.87 ? 91  LYS B C   1 
ATOM   2979 O O   . LYS B 2 92  ? -37.420 -34.341 -1.420  1.00 16.24 ? 91  LYS B O   1 
ATOM   2980 C CB  . LYS B 2 92  ? -38.789 -35.588 1.072   1.00 16.41 ? 91  LYS B CB  1 
ATOM   2981 C CG  . LYS B 2 92  ? -39.867 -34.604 1.531   1.00 24.65 ? 91  LYS B CG  1 
ATOM   2982 C CD  . LYS B 2 92  ? -39.746 -34.225 2.999   1.00 29.82 ? 91  LYS B CD  1 
ATOM   2983 C CE  . LYS B 2 92  ? -40.713 -35.048 3.865   1.00 38.21 ? 91  LYS B CE  1 
ATOM   2984 N NZ  . LYS B 2 92  ? -40.091 -35.637 5.106   1.00 33.70 ? 91  LYS B NZ  1 
ATOM   2985 N N   . ILE B 2 93  ? -39.614 -34.165 -1.916  1.00 17.55 ? 92  ILE B N   1 
ATOM   2986 C CA  . ILE B 2 93  ? -39.448 -33.022 -2.807  1.00 19.17 ? 92  ILE B CA  1 
ATOM   2987 C C   . ILE B 2 93  ? -40.138 -31.828 -2.168  1.00 21.57 ? 92  ILE B C   1 
ATOM   2988 O O   . ILE B 2 93  ? -41.354 -31.845 -1.949  1.00 20.44 ? 92  ILE B O   1 
ATOM   2989 C CB  . ILE B 2 93  ? -39.980 -33.314 -4.219  1.00 19.79 ? 92  ILE B CB  1 
ATOM   2990 C CG1 . ILE B 2 93  ? -39.160 -34.447 -4.848  1.00 19.66 ? 92  ILE B CG1 1 
ATOM   2991 C CG2 . ILE B 2 93  ? -39.871 -32.079 -5.104  1.00 20.86 ? 92  ILE B CG2 1 
ATOM   2992 C CD1 . ILE B 2 93  ? -39.618 -34.861 -6.232  1.00 22.97 ? 92  ILE B CD1 1 
ATOM   2993 N N   . VAL B 2 94  ? -39.354 -30.801 -1.850  1.00 19.34 ? 93  VAL B N   1 
ATOM   2994 C CA  . VAL B 2 94  ? -39.838 -29.623 -1.141  1.00 18.87 ? 93  VAL B CA  1 
ATOM   2995 C C   . VAL B 2 94  ? -39.731 -28.457 -2.110  1.00 20.35 ? 93  VAL B C   1 
ATOM   2996 O O   . VAL B 2 94  ? -38.644 -28.174 -2.626  1.00 18.82 ? 93  VAL B O   1 
ATOM   2997 C CB  . VAL B 2 94  ? -39.012 -29.350 0.128   1.00 19.11 ? 93  VAL B CB  1 
ATOM   2998 C CG1 . VAL B 2 94  ? -39.452 -28.039 0.776   1.00 15.66 ? 93  VAL B CG1 1 
ATOM   2999 C CG2 . VAL B 2 94  ? -39.067 -30.527 1.082   1.00 17.55 ? 93  VAL B CG2 1 
ATOM   3000 N N   . LYS B 2 95  ? -40.844 -27.787 -2.363  1.00 16.48 ? 94  LYS B N   1 
ATOM   3001 C CA  . LYS B 2 95  ? -40.868 -26.719 -3.352  1.00 20.09 ? 94  LYS B CA  1 
ATOM   3002 C C   . LYS B 2 95  ? -40.402 -25.421 -2.727  1.00 17.81 ? 94  LYS B C   1 
ATOM   3003 O O   . LYS B 2 95  ? -40.670 -25.150 -1.554  1.00 21.57 ? 94  LYS B O   1 
ATOM   3004 C CB  . LYS B 2 95  ? -42.285 -26.504 -3.890  1.00 18.00 ? 94  LYS B CB  1 
ATOM   3005 C CG  . LYS B 2 95  ? -42.949 -27.717 -4.527  1.00 24.82 ? 94  LYS B CG  1 
ATOM   3006 C CD  . LYS B 2 95  ? -43.983 -27.251 -5.527  1.00 28.08 ? 94  LYS B CD  1 
ATOM   3007 C CE  . LYS B 2 95  ? -45.350 -27.835 -5.234  1.00 40.18 ? 94  LYS B CE  1 
ATOM   3008 N NZ  . LYS B 2 95  ? -46.044 -28.292 -6.478  1.00 38.87 ? 94  LYS B NZ  1 
ATOM   3009 N N   . TRP B 2 96  ? -39.752 -24.589 -3.531  1.00 15.83 ? 95  TRP B N   1 
ATOM   3010 C CA  . TRP B 2 96  ? -39.312 -23.282 -3.057  1.00 17.05 ? 95  TRP B CA  1 
ATOM   3011 C C   . TRP B 2 96  ? -40.500 -22.335 -2.962  1.00 19.39 ? 95  TRP B C   1 
ATOM   3012 O O   . TRP B 2 96  ? -41.229 -22.127 -3.937  1.00 20.34 ? 95  TRP B O   1 
ATOM   3013 C CB  . TRP B 2 96  ? -38.239 -22.704 -3.969  1.00 19.01 ? 95  TRP B CB  1 
ATOM   3014 C CG  . TRP B 2 96  ? -37.814 -21.308 -3.583  1.00 19.40 ? 95  TRP B CG  1 
ATOM   3015 C CD1 . TRP B 2 96  ? -37.466 -20.879 -2.335  1.00 19.65 ? 95  TRP B CD1 1 
ATOM   3016 C CD2 . TRP B 2 96  ? -37.572 -20.209 -4.465  1.00 17.69 ? 95  TRP B CD2 1 
ATOM   3017 N NE1 . TRP B 2 96  ? -37.078 -19.563 -2.376  1.00 20.03 ? 95  TRP B NE1 1 
ATOM   3018 C CE2 . TRP B 2 96  ? -37.129 -19.129 -3.675  1.00 19.23 ? 95  TRP B CE2 1 
ATOM   3019 C CE3 . TRP B 2 96  ? -37.711 -20.026 -5.847  1.00 19.42 ? 95  TRP B CE3 1 
ATOM   3020 C CZ2 . TRP B 2 96  ? -36.822 -17.886 -4.214  1.00 16.46 ? 95  TRP B CZ2 1 
ATOM   3021 C CZ3 . TRP B 2 96  ? -37.417 -18.785 -6.381  1.00 23.08 ? 95  TRP B CZ3 1 
ATOM   3022 C CH2 . TRP B 2 96  ? -36.972 -17.730 -5.568  1.00 22.11 ? 95  TRP B CH2 1 
ATOM   3023 N N   . ASP B 2 97  ? -40.702 -21.785 -1.776  1.00 19.65 ? 96  ASP B N   1 
ATOM   3024 C CA  . ASP B 2 97  ? -41.739 -20.806 -1.490  1.00 20.30 ? 96  ASP B CA  1 
ATOM   3025 C C   . ASP B 2 97  ? -41.005 -19.530 -1.114  1.00 22.77 ? 96  ASP B C   1 
ATOM   3026 O O   . ASP B 2 97  ? -40.222 -19.530 -0.155  1.00 24.69 ? 96  ASP B O   1 
ATOM   3027 C CB  . ASP B 2 97  ? -42.623 -21.328 -0.348  1.00 21.00 ? 96  ASP B CB  1 
ATOM   3028 C CG  . ASP B 2 97  ? -43.669 -20.338 0.121   1.00 29.99 ? 96  ASP B CG  1 
ATOM   3029 O OD1 . ASP B 2 97  ? -43.495 -19.113 -0.049  1.00 30.40 ? 96  ASP B OD1 1 
ATOM   3030 O OD2 . ASP B 2 97  ? -44.683 -20.808 0.690   1.00 29.07 ? 96  ASP B OD2 1 
ATOM   3031 N N   . ARG B 2 98  ? -41.233 -18.451 -1.866  1.00 21.49 ? 97  ARG B N   1 
ATOM   3032 C CA  . ARG B 2 98  ? -40.419 -17.260 -1.628  1.00 25.34 ? 97  ARG B CA  1 
ATOM   3033 C C   . ARG B 2 98  ? -40.577 -16.680 -0.220  1.00 32.69 ? 97  ARG B C   1 
ATOM   3034 O O   . ARG B 2 98  ? -39.768 -15.824 0.169   1.00 27.33 ? 97  ARG B O   1 
ATOM   3035 C CB  . ARG B 2 98  ? -40.706 -16.204 -2.689  1.00 27.15 ? 97  ARG B CB  1 
ATOM   3036 C CG  . ARG B 2 98  ? -40.361 -16.683 -4.100  1.00 27.34 ? 97  ARG B CG  1 
ATOM   3037 C CD  . ARG B 2 98  ? -40.872 -15.744 -5.186  1.00 29.55 ? 97  ARG B CD  1 
ATOM   3038 N NE  . ARG B 2 98  ? -40.580 -16.259 -6.521  1.00 29.16 ? 97  ARG B NE  1 
ATOM   3039 C CZ  . ARG B 2 98  ? -40.048 -15.546 -7.508  1.00 32.39 ? 97  ARG B CZ  1 
ATOM   3040 N NH1 . ARG B 2 98  ? -39.776 -14.258 -7.367  1.00 32.17 ? 97  ARG B NH1 1 
ATOM   3041 N NH2 . ARG B 2 98  ? -39.785 -16.140 -8.669  1.00 31.33 ? 97  ARG B NH2 1 
ATOM   3042 N N   . ASP B 2 99  ? -41.551 -17.151 0.573   1.00 27.43 ? 98  ASP B N   1 
ATOM   3043 C CA  . ASP B 2 99  ? -41.660 -16.760 1.976   1.00 29.34 ? 98  ASP B CA  1 
ATOM   3044 C C   . ASP B 2 99  ? -41.599 -17.958 2.936   1.00 29.21 ? 98  ASP B C   1 
ATOM   3045 O O   . ASP B 2 99  ? -42.114 -17.868 4.051   1.00 32.78 ? 98  ASP B O   1 
ATOM   3046 C CB  . ASP B 2 99  ? -42.949 -15.958 2.200   1.00 29.61 ? 98  ASP B CB  1 
ATOM   3047 C CG  . ASP B 2 99  ? -42.944 -15.203 3.532   1.00 31.99 ? 98  ASP B CG  1 
ATOM   3048 O OD1 . ASP B 2 99  ? -41.865 -14.677 3.932   1.00 25.73 ? 98  ASP B OD1 1 
ATOM   3049 O OD2 . ASP B 2 99  ? -44.016 -15.176 4.192   1.00 27.98 ? 98  ASP B OD2 1 
ATOM   3050 N N   . MET B 2 100 ? -40.958 -19.064 2.538   1.00 31.65 ? 99  MET B N   1 
ATOM   3051 C CA  . MET B 2 100 ? -40.943 -20.371 3.264   1.00 26.68 ? 99  MET B CA  1 
ATOM   3052 C C   . MET B 2 100 ? -42.326 -20.894 3.707   1.00 31.03 ? 99  MET B C   1 
ATOM   3053 O O   . MET B 2 100 ? -42.940 -20.303 4.588   1.00 35.64 ? 99  MET B O   1 
ATOM   3054 C CB  . MET B 2 100 ? -40.073 -20.306 4.519   1.00 32.60 ? 99  MET B CB  1 
ATOM   3055 C CG  . MET B 2 100 ? -38.542 -20.576 4.347   1.00 20.45 ? 99  MET B CG  1 
ATOM   3056 S SD  . MET B 2 100 ? -37.758 -19.352 3.295   1.00 38.77 ? 99  MET B SD  1 
ATOM   3057 C CE  . MET B 2 100 ? -37.932 -19.936 1.632   1.00 28.38 ? 99  MET B CE  1 
ATOM   3058 O OXT . MET B 2 100 ? -42.878 -21.930 3.302   1.00 32.82 ? 99  MET B OXT 1 
ATOM   3059 N N   . ASN C 3 1   ? -5.627  -25.729 15.457  1.00 17.40 ? 1   ASN E N   1 
ATOM   3060 C CA  . ASN C 3 1   ? -4.606  -26.764 15.557  1.00 18.44 ? 1   ASN E CA  1 
ATOM   3061 C C   . ASN C 3 1   ? -5.251  -28.083 15.934  1.00 16.65 ? 1   ASN E C   1 
ATOM   3062 O O   . ASN C 3 1   ? -5.889  -28.185 16.985  1.00 16.36 ? 1   ASN E O   1 
ATOM   3063 C CB  . ASN C 3 1   ? -3.549  -26.394 16.615  1.00 21.16 ? 1   ASN E CB  1 
ATOM   3064 C CG  . ASN C 3 1   ? -2.717  -25.216 16.210  1.00 26.06 ? 1   ASN E CG  1 
ATOM   3065 O OD1 . ASN C 3 1   ? -2.657  -24.219 16.926  1.00 27.96 ? 1   ASN E OD1 1 
ATOM   3066 N ND2 . ASN C 3 1   ? -2.030  -25.330 15.083  1.00 27.73 ? 1   ASN E ND2 1 
ATOM   3067 N N   . TYR C 3 2   ? -5.084  -29.093 15.089  1.00 14.91 ? 2   TYR E N   1 
ATOM   3068 C CA  . TYR C 3 2   ? -5.597  -30.424 15.389  1.00 17.26 ? 2   TYR E CA  1 
ATOM   3069 C C   . TYR C 3 2   ? -4.780  -31.068 16.509  1.00 17.50 ? 2   TYR E C   1 
ATOM   3070 O O   . TYR C 3 2   ? -3.673  -30.626 16.841  1.00 16.58 ? 2   TYR E O   1 
ATOM   3071 C CB  . TYR C 3 2   ? -5.533  -31.294 14.135  1.00 15.52 ? 2   TYR E CB  1 
ATOM   3072 C CG  . TYR C 3 2   ? -6.679  -32.243 13.855  1.00 12.70 ? 2   TYR E CG  1 
ATOM   3073 C CD1 . TYR C 3 2   ? -7.848  -31.796 13.262  1.00 13.29 ? 2   TYR E CD1 1 
ATOM   3074 C CD2 . TYR C 3 2   ? -6.546  -33.608 14.096  1.00 12.17 ? 2   TYR E CD2 1 
ATOM   3075 C CE1 . TYR C 3 2   ? -8.876  -32.670 12.957  1.00 13.96 ? 2   TYR E CE1 1 
ATOM   3076 C CE2 . TYR C 3 2   ? -7.560  -34.484 13.798  1.00 13.33 ? 2   TYR E CE2 1 
ATOM   3077 C CZ  . TYR C 3 2   ? -8.727  -34.012 13.234  1.00 14.57 ? 2   TYR E CZ  1 
ATOM   3078 O OH  . TYR C 3 2   ? -9.746  -34.888 12.942  1.00 14.29 ? 2   TYR E OH  1 
ATOM   3079 N N   . ASN C 3 3   ? -5.330  -32.141 17.088  1.00 16.29 ? 3   ASN E N   1 
ATOM   3080 C CA  . ASN C 3 3   ? -4.623  -32.945 18.079  1.00 14.30 ? 3   ASN E CA  1 
ATOM   3081 C C   . ASN C 3 3   ? -4.054  -34.212 17.443  1.00 16.75 ? 3   ASN E C   1 
ATOM   3082 O O   . ASN C 3 3   ? -4.528  -34.683 16.410  1.00 17.23 ? 3   ASN E O   1 
ATOM   3083 C CB  . ASN C 3 3   ? -5.558  -33.321 19.236  1.00 15.78 ? 3   ASN E CB  1 
ATOM   3084 C CG  . ASN C 3 3   ? -4.811  -33.830 20.480  1.00 18.23 ? 3   ASN E CG  1 
ATOM   3085 O OD1 . ASN C 3 3   ? -3.570  -33.741 20.590  1.00 19.43 ? 3   ASN E OD1 1 
ATOM   3086 N ND2 . ASN C 3 3   ? -5.575  -34.365 21.430  1.00 13.66 ? 3   ASN E ND2 1 
ATOM   3087 N N   . TYR C 3 4   ? -3.033  -34.776 18.086  1.00 14.68 ? 4   TYR E N   1 
ATOM   3088 C CA  . TYR C 3 4   ? -2.504  -36.076 17.679  1.00 17.05 ? 4   TYR E CA  1 
ATOM   3089 C C   . TYR C 3 4   ? -3.348  -37.170 18.326  1.00 17.27 ? 4   TYR E C   1 
ATOM   3090 O O   . TYR C 3 4   ? -3.354  -37.307 19.552  1.00 17.47 ? 4   TYR E O   1 
ATOM   3091 C CB  . TYR C 3 4   ? -1.035  -36.202 18.080  1.00 17.16 ? 4   TYR E CB  1 
ATOM   3092 C CG  . TYR C 3 4   ? -0.070  -35.586 17.079  1.00 16.61 ? 4   TYR E CG  1 
ATOM   3093 C CD1 . TYR C 3 4   ? 0.236   -36.241 15.894  1.00 18.45 ? 4   TYR E CD1 1 
ATOM   3094 C CD2 . TYR C 3 4   ? 0.523   -34.348 17.317  1.00 18.91 ? 4   TYR E CD2 1 
ATOM   3095 C CE1 . TYR C 3 4   ? 1.114   -35.689 14.974  1.00 15.91 ? 4   TYR E CE1 1 
ATOM   3096 C CE2 . TYR C 3 4   ? 1.408   -33.782 16.396  1.00 18.36 ? 4   TYR E CE2 1 
ATOM   3097 C CZ  . TYR C 3 4   ? 1.694   -34.464 15.227  1.00 21.39 ? 4   TYR E CZ  1 
ATOM   3098 O OH  . TYR C 3 4   ? 2.563   -33.933 14.290  1.00 25.68 ? 4   TYR E OH  1 
ATOM   3099 N N   . LEU C 3 5   ? -4.050  -37.963 17.513  1.00 13.83 ? 5   LEU E N   1 
ATOM   3100 C CA  . LEU C 3 5   ? -4.985  -38.970 18.017  1.00 16.63 ? 5   LEU E CA  1 
ATOM   3101 C C   . LEU C 3 5   ? -4.554  -40.357 17.580  1.00 16.99 ? 5   LEU E C   1 
ATOM   3102 O O   . LEU C 3 5   ? -4.777  -40.745 16.427  1.00 16.57 ? 5   LEU E O   1 
ATOM   3103 C CB  . LEU C 3 5   ? -6.423  -38.728 17.553  1.00 19.04 ? 5   LEU E CB  1 
ATOM   3104 C CG  . LEU C 3 5   ? -7.349  -37.606 18.026  1.00 24.79 ? 5   LEU E CG  1 
ATOM   3105 C CD1 . LEU C 3 5   ? -7.254  -37.362 19.538  1.00 20.26 ? 5   LEU E CD1 1 
ATOM   3106 C CD2 . LEU C 3 5   ? -7.280  -36.331 17.214  1.00 26.27 ? 5   LEU E CD2 1 
ATOM   3107 N N   . TYR C 3 6   ? -4.008  -41.124 18.520  1.00 14.86 ? 6   TYR E N   1 
ATOM   3108 C CA  . TYR C 3 6   ? -3.535  -42.469 18.258  1.00 16.19 ? 6   TYR E CA  1 
ATOM   3109 C C   . TYR C 3 6   ? -4.189  -43.532 19.131  1.00 16.33 ? 6   TYR E C   1 
ATOM   3110 O O   . TYR C 3 6   ? -3.996  -44.724 18.861  1.00 17.99 ? 6   TYR E O   1 
ATOM   3111 C CB  . TYR C 3 6   ? -2.012  -42.532 18.461  1.00 15.80 ? 6   TYR E CB  1 
ATOM   3112 C CG  . TYR C 3 6   ? -1.234  -41.726 17.450  1.00 15.48 ? 6   TYR E CG  1 
ATOM   3113 C CD1 . TYR C 3 6   ? -0.988  -42.222 16.177  1.00 14.48 ? 6   TYR E CD1 1 
ATOM   3114 C CD2 . TYR C 3 6   ? -0.765  -40.457 17.766  1.00 14.82 ? 6   TYR E CD2 1 
ATOM   3115 C CE1 . TYR C 3 6   ? -0.270  -41.483 15.247  1.00 14.52 ? 6   TYR E CE1 1 
ATOM   3116 C CE2 . TYR C 3 6   ? -0.055  -39.710 16.849  1.00 14.93 ? 6   TYR E CE2 1 
ATOM   3117 C CZ  . TYR C 3 6   ? 0.189   -40.225 15.588  1.00 17.32 ? 6   TYR E CZ  1 
ATOM   3118 O OH  . TYR C 3 6   ? 0.921   -39.481 14.682  1.00 17.98 ? 6   TYR E OH  1 
ATOM   3119 N N   . ARG C 3 7   ? -4.941  -43.150 20.164  1.00 14.67 ? 7   ARG E N   1 
ATOM   3120 C CA  . ARG C 3 7   ? -5.416  -44.119 21.142  1.00 15.69 ? 7   ARG E CA  1 
ATOM   3121 C C   . ARG C 3 7   ? -6.544  -44.959 20.572  1.00 19.12 ? 7   ARG E C   1 
ATOM   3122 O O   . ARG C 3 7   ? -7.462  -44.441 19.930  1.00 19.44 ? 7   ARG E O   1 
ATOM   3123 C CB  . ARG C 3 7   ? -5.905  -43.425 22.408  1.00 20.91 ? 7   ARG E CB  1 
ATOM   3124 C CG  . ARG C 3 7   ? -4.876  -42.493 23.039  1.00 28.96 ? 7   ARG E CG  1 
ATOM   3125 C CD  . ARG C 3 7   ? -3.613  -43.214 23.506  1.00 31.46 ? 7   ARG E CD  1 
ATOM   3126 N NE  . ARG C 3 7   ? -3.905  -44.471 24.183  1.00 33.09 ? 7   ARG E NE  1 
ATOM   3127 C CZ  . ARG C 3 7   ? -3.073  -45.082 25.015  1.00 33.65 ? 7   ARG E CZ  1 
ATOM   3128 N NH1 . ARG C 3 7   ? -1.970  -44.493 25.443  1.00 31.21 ? 7   ARG E NH1 1 
ATOM   3129 N NH2 . ARG C 3 7   ? -3.376  -46.300 25.456  1.00 36.54 ? 7   ARG E NH2 1 
ATOM   3130 N N   . LEU C 3 8   ? -6.517  -46.243 20.879  1.00 18.27 ? 8   LEU E N   1 
ATOM   3131 C CA  . LEU C 3 8   ? -7.535  -47.174 20.343  1.00 14.78 ? 8   LEU E CA  1 
ATOM   3132 C C   . LEU C 3 8   ? -8.553  -47.584 21.410  1.00 20.35 ? 8   LEU E C   1 
ATOM   3133 O O   . LEU C 3 8   ? -8.187  -47.629 22.576  1.00 17.88 ? 8   LEU E O   1 
ATOM   3134 C CB  . LEU C 3 8   ? -6.830  -48.413 19.799  1.00 17.95 ? 8   LEU E CB  1 
ATOM   3135 C CG  . LEU C 3 8   ? -5.877  -48.162 18.634  1.00 19.84 ? 8   LEU E CG  1 
ATOM   3136 C CD1 . LEU C 3 8   ? -5.170  -49.448 18.243  1.00 21.27 ? 8   LEU E CD1 1 
ATOM   3137 C CD2 . LEU C 3 8   ? -6.626  -47.584 17.447  1.00 18.21 ? 8   LEU E CD2 1 
ATOM   3138 N N   . PHE C 3 9   ? -9.767  -47.900 20.972  1.00 16.45 ? 9   PHE E N   1 
ATOM   3139 C CA  . PHE C 3 9   ? -10.856 -48.353 21.869  1.00 19.80 ? 9   PHE E CA  1 
ATOM   3140 C C   . PHE C 3 9   ? -10.486 -49.682 22.542  1.00 23.26 ? 9   PHE E C   1 
ATOM   3141 O O   . PHE C 3 9   ? -9.530  -50.308 22.153  1.00 24.40 ? 9   PHE E O   1 
ATOM   3142 C CB  . PHE C 3 9   ? -12.113 -48.563 21.026  1.00 28.67 ? 9   PHE E CB  1 
ATOM   3143 C CG  . PHE C 3 9   ? -12.839 -47.318 20.581  1.00 21.33 ? 9   PHE E CG  1 
ATOM   3144 C CD1 . PHE C 3 9   ? -12.433 -46.065 20.998  1.00 16.60 ? 9   PHE E CD1 1 
ATOM   3145 C CD2 . PHE C 3 9   ? -13.946 -47.406 19.752  1.00 17.14 ? 9   PHE E CD2 1 
ATOM   3146 C CE1 . PHE C 3 9   ? -13.111 -44.928 20.593  1.00 21.00 ? 9   PHE E CE1 1 
ATOM   3147 C CE2 . PHE C 3 9   ? -14.619 -46.268 19.339  1.00 17.38 ? 9   PHE E CE2 1 
ATOM   3148 C CZ  . PHE C 3 9   ? -14.201 -45.032 19.763  1.00 18.79 ? 9   PHE E CZ  1 
ATOM   3149 O OXT . PHE C 3 9   ? -11.215 -50.069 23.453  1.00 22.96 ? 9   PHE E OXT 1 
HETATM 3150 O O   . HOH D 4 .   ? -20.680 -51.453 1.310   1.00 42.96 ? 301 HOH A O   1 
HETATM 3151 O O   . HOH D 4 .   ? -30.837 -1.237  28.014  1.00 52.74 ? 302 HOH A O   1 
HETATM 3152 O O   . HOH D 4 .   ? -22.253 -54.889 10.372  1.00 29.03 ? 303 HOH A O   1 
HETATM 3153 O O   . HOH D 4 .   ? -38.172 -5.186  22.654  1.00 35.81 ? 304 HOH A O   1 
HETATM 3154 O O   . HOH D 4 .   ? 0.874   -26.778 21.583  1.00 27.43 ? 305 HOH A O   1 
HETATM 3155 O O   . HOH D 4 .   ? -26.637 -7.781  9.843   1.00 30.85 ? 306 HOH A O   1 
HETATM 3156 O O   . HOH D 4 .   ? -13.262 -42.452 34.316  1.00 23.16 ? 307 HOH A O   1 
HETATM 3157 O O   . HOH D 4 .   ? -19.621 -33.566 26.531  1.00 25.81 ? 308 HOH A O   1 
HETATM 3158 O O   . HOH D 4 .   ? -45.396 -21.563 8.710   1.00 31.53 ? 309 HOH A O   1 
HETATM 3159 O O   . HOH D 4 .   ? -20.592 -12.140 6.823   1.00 35.52 ? 310 HOH A O   1 
HETATM 3160 O O   . HOH D 4 .   ? -9.638  -24.936 0.116   1.00 30.46 ? 311 HOH A O   1 
HETATM 3161 O O   . HOH D 4 .   ? -29.626 -19.997 16.393  1.00 15.74 ? 312 HOH A O   1 
HETATM 3162 O O   . HOH D 4 .   ? -56.251 -10.696 8.731   1.00 33.16 ? 313 HOH A O   1 
HETATM 3163 O O   . HOH D 4 .   ? -24.740 -49.933 16.238  1.00 26.77 ? 314 HOH A O   1 
HETATM 3164 O O   . HOH D 4 .   ? -14.300 -26.899 32.311  1.00 37.87 ? 315 HOH A O   1 
HETATM 3165 O O   . HOH D 4 .   ? -7.888  -35.250 0.672   1.00 23.43 ? 316 HOH A O   1 
HETATM 3166 O O   . HOH D 4 .   ? -0.617  -36.353 2.261   1.00 29.40 ? 317 HOH A O   1 
HETATM 3167 O O   . HOH D 4 .   ? -4.298  -38.580 -4.433  1.00 39.39 ? 318 HOH A O   1 
HETATM 3168 O O   . HOH D 4 .   ? -11.100 -11.981 8.504   1.00 32.08 ? 319 HOH A O   1 
HETATM 3169 O O   . HOH D 4 .   ? -52.581 -15.329 1.543   1.00 34.14 ? 320 HOH A O   1 
HETATM 3170 O O   . HOH D 4 .   ? -30.207 -16.128 21.979  1.00 27.23 ? 321 HOH A O   1 
HETATM 3171 O O   . HOH D 4 .   ? -23.664 -19.120 17.968  1.00 19.64 ? 322 HOH A O   1 
HETATM 3172 O O   . HOH D 4 .   ? -48.195 -8.302  15.028  1.00 22.98 ? 323 HOH A O   1 
HETATM 3173 O O   . HOH D 4 .   ? -52.187 -14.234 25.614  1.00 29.65 ? 324 HOH A O   1 
HETATM 3174 O O   . HOH D 4 .   ? -1.854  -33.608 25.055  1.00 19.30 ? 325 HOH A O   1 
HETATM 3175 O O   . HOH D 4 .   ? -15.097 -49.744 4.709   1.00 31.59 ? 326 HOH A O   1 
HETATM 3176 O O   . HOH D 4 .   ? -18.209 -26.128 3.896   1.00 16.14 ? 327 HOH A O   1 
HETATM 3177 O O   . HOH D 4 .   ? -21.835 -42.067 14.878  1.00 14.26 ? 328 HOH A O   1 
HETATM 3178 O O   . HOH D 4 .   ? -16.853 -15.856 15.604  1.00 21.91 ? 329 HOH A O   1 
HETATM 3179 O O   . HOH D 4 .   ? -6.853  -13.522 20.355  1.00 28.21 ? 330 HOH A O   1 
HETATM 3180 O O   . HOH D 4 .   ? -33.784 -5.281  12.047  1.00 31.54 ? 331 HOH A O   1 
HETATM 3181 O O   . HOH D 4 .   ? -13.599 -56.052 13.588  1.00 30.04 ? 332 HOH A O   1 
HETATM 3182 O O   . HOH D 4 .   ? -42.087 -25.095 7.781   1.00 36.75 ? 333 HOH A O   1 
HETATM 3183 O O   . HOH D 4 .   ? -28.183 -40.420 19.650  1.00 29.88 ? 334 HOH A O   1 
HETATM 3184 O O   . HOH D 4 .   ? -14.023 -40.239 13.157  1.00 16.40 ? 335 HOH A O   1 
HETATM 3185 O O   . HOH D 4 .   ? -32.559 -30.625 12.367  1.00 27.88 ? 336 HOH A O   1 
HETATM 3186 O O   . HOH D 4 .   ? -4.674  -38.218 21.755  1.00 32.02 ? 337 HOH A O   1 
HETATM 3187 O O   . HOH D 4 .   ? -23.940 -45.564 6.412   1.00 29.48 ? 338 HOH A O   1 
HETATM 3188 O O   . HOH D 4 .   ? -7.609  -41.005 33.823  1.00 20.27 ? 339 HOH A O   1 
HETATM 3189 O O   . HOH D 4 .   ? 6.772   -28.710 7.056   1.00 27.61 ? 340 HOH A O   1 
HETATM 3190 O O   . HOH D 4 .   ? -4.323  -17.790 11.269  1.00 29.60 ? 341 HOH A O   1 
HETATM 3191 O O   . HOH D 4 .   ? -60.539 -7.864  23.810  1.00 16.85 ? 342 HOH A O   1 
HETATM 3192 O O   . HOH D 4 .   ? -18.634 -19.704 20.495  1.00 30.75 ? 343 HOH A O   1 
HETATM 3193 O O   . HOH D 4 .   ? -5.126  -49.919 29.541  1.00 27.55 ? 344 HOH A O   1 
HETATM 3194 O O   . HOH D 4 .   ? -11.252 -43.466 9.275   1.00 19.51 ? 345 HOH A O   1 
HETATM 3195 O O   . HOH D 4 .   ? -58.697 -20.860 8.832   1.00 36.91 ? 346 HOH A O   1 
HETATM 3196 O O   . HOH D 4 .   ? -7.530  -18.121 23.890  1.00 34.68 ? 347 HOH A O   1 
HETATM 3197 O O   . HOH D 4 .   ? -42.265 -6.249  6.568   1.00 18.54 ? 348 HOH A O   1 
HETATM 3198 O O   . HOH D 4 .   ? -17.913 -50.524 12.803  1.00 17.68 ? 349 HOH A O   1 
HETATM 3199 O O   . HOH D 4 .   ? -22.342 -46.902 30.994  1.00 26.63 ? 350 HOH A O   1 
HETATM 3200 O O   . HOH D 4 .   ? 2.056   -20.546 10.106  1.00 34.51 ? 351 HOH A O   1 
HETATM 3201 O O   . HOH D 4 .   ? -61.770 -11.325 17.572  1.00 23.41 ? 352 HOH A O   1 
HETATM 3202 O O   . HOH D 4 .   ? -55.616 -15.980 19.460  1.00 30.57 ? 353 HOH A O   1 
HETATM 3203 O O   . HOH D 4 .   ? 0.528   -26.913 12.982  1.00 28.11 ? 354 HOH A O   1 
HETATM 3204 O O   . HOH D 4 .   ? -10.943 -42.913 1.982   1.00 27.65 ? 355 HOH A O   1 
HETATM 3205 O O   . HOH D 4 .   ? -17.015 -23.845 17.298  1.00 19.43 ? 356 HOH A O   1 
HETATM 3206 O O   . HOH D 4 .   ? -2.778  -40.090 1.641   1.00 33.52 ? 357 HOH A O   1 
HETATM 3207 O O   . HOH D 4 .   ? -1.160  -33.705 29.096  1.00 14.54 ? 358 HOH A O   1 
HETATM 3208 O O   . HOH D 4 .   ? 6.883   -31.271 5.907   1.00 32.98 ? 359 HOH A O   1 
HETATM 3209 O O   . HOH D 4 .   ? -49.329 -20.969 8.397   1.00 31.24 ? 360 HOH A O   1 
HETATM 3210 O O   . HOH D 4 .   ? -30.215 -30.430 14.034  1.00 29.27 ? 361 HOH A O   1 
HETATM 3211 O O   . HOH D 4 .   ? -8.036  -41.761 31.135  1.00 17.92 ? 362 HOH A O   1 
HETATM 3212 O O   . HOH D 4 .   ? -24.917 -46.565 30.532  1.00 29.87 ? 363 HOH A O   1 
HETATM 3213 O O   . HOH D 4 .   ? -1.699  -17.950 20.592  1.00 32.12 ? 364 HOH A O   1 
HETATM 3214 O O   . HOH D 4 .   ? 4.126   -28.876 1.533   1.00 29.37 ? 365 HOH A O   1 
HETATM 3215 O O   . HOH D 4 .   ? -15.923 -31.757 28.957  1.00 23.74 ? 366 HOH A O   1 
HETATM 3216 O O   . HOH D 4 .   ? -6.684  -40.549 37.046  1.00 28.54 ? 367 HOH A O   1 
HETATM 3217 O O   . HOH D 4 .   ? -1.190  -33.808 -2.859  1.00 19.79 ? 368 HOH A O   1 
HETATM 3218 O O   . HOH D 4 .   ? -4.963  -22.931 29.810  1.00 23.35 ? 369 HOH A O   1 
HETATM 3219 O O   . HOH D 4 .   ? -6.194  -27.104 11.625  1.00 14.39 ? 370 HOH A O   1 
HETATM 3220 O O   . HOH D 4 .   ? -17.495 -51.258 10.111  1.00 22.60 ? 371 HOH A O   1 
HETATM 3221 O O   . HOH D 4 .   ? -15.388 -19.726 6.396   1.00 25.10 ? 372 HOH A O   1 
HETATM 3222 O O   . HOH D 4 .   ? -47.947 -9.245  22.441  1.00 19.51 ? 373 HOH A O   1 
HETATM 3223 O O   . HOH D 4 .   ? -24.423 -45.423 11.080  1.00 23.53 ? 374 HOH A O   1 
HETATM 3224 O O   . HOH D 4 .   ? -46.488 -24.082 15.326  1.00 42.25 ? 375 HOH A O   1 
HETATM 3225 O O   . HOH D 4 .   ? -17.999 -54.005 29.832  1.00 27.08 ? 376 HOH A O   1 
HETATM 3226 O O   . HOH D 4 .   ? -46.961 -18.072 4.655   1.00 28.52 ? 377 HOH A O   1 
HETATM 3227 O O   . HOH D 4 .   ? 0.431   -38.887 10.053  1.00 24.25 ? 378 HOH A O   1 
HETATM 3228 O O   . HOH D 4 .   ? -36.928 -13.657 21.952  1.00 21.77 ? 379 HOH A O   1 
HETATM 3229 O O   . HOH D 4 .   ? -18.814 -53.724 9.242   1.00 31.28 ? 380 HOH A O   1 
HETATM 3230 O O   . HOH D 4 .   ? -10.547 -34.465 -5.210  1.00 29.86 ? 381 HOH A O   1 
HETATM 3231 O O   . HOH D 4 .   ? -6.025  -20.560 30.069  1.00 32.18 ? 382 HOH A O   1 
HETATM 3232 O O   . HOH D 4 .   ? -14.317 -29.340 -3.120  1.00 40.87 ? 383 HOH A O   1 
HETATM 3233 O O   . HOH D 4 .   ? -8.777  -40.896 22.782  1.00 28.88 ? 384 HOH A O   1 
HETATM 3234 O O   . HOH D 4 .   ? -31.647 -2.855  19.077  1.00 38.69 ? 385 HOH A O   1 
HETATM 3235 O O   . HOH D 4 .   ? -27.323 -23.186 11.182  1.00 23.83 ? 386 HOH A O   1 
HETATM 3236 O O   . HOH D 4 .   ? -35.032 -8.735  7.066   1.00 16.70 ? 387 HOH A O   1 
HETATM 3237 O O   . HOH D 4 .   ? -15.794 -34.313 26.066  1.00 14.79 ? 388 HOH A O   1 
HETATM 3238 O O   . HOH D 4 .   ? -11.093 -51.336 7.648   1.00 41.06 ? 389 HOH A O   1 
HETATM 3239 O O   . HOH D 4 .   ? -8.433  -32.742 -3.679  1.00 25.98 ? 390 HOH A O   1 
HETATM 3240 O O   . HOH D 4 .   ? -20.203 -18.899 9.133   1.00 25.41 ? 391 HOH A O   1 
HETATM 3241 O O   . HOH D 4 .   ? -34.854 -23.388 17.083  1.00 29.65 ? 392 HOH A O   1 
HETATM 3242 O O   . HOH D 4 .   ? -14.612 -32.872 -0.026  1.00 30.44 ? 393 HOH A O   1 
HETATM 3243 O O   . HOH D 4 .   ? -41.788 -25.234 15.647  1.00 28.92 ? 394 HOH A O   1 
HETATM 3244 O O   . HOH D 4 .   ? -30.210 -4.618  12.298  1.00 30.37 ? 395 HOH A O   1 
HETATM 3245 O O   . HOH D 4 .   ? -7.161  -43.119 35.617  1.00 26.19 ? 396 HOH A O   1 
HETATM 3246 O O   . HOH D 4 .   ? -20.106 -39.468 23.796  1.00 12.73 ? 397 HOH A O   1 
HETATM 3247 O O   . HOH D 4 .   ? -0.192  -37.183 25.044  0.50 28.23 ? 398 HOH A O   1 
HETATM 3248 O O   . HOH D 4 .   ? -54.942 -12.857 24.381  1.00 24.77 ? 399 HOH A O   1 
HETATM 3249 O O   . HOH D 4 .   ? -12.700 -49.812 9.530   1.00 23.32 ? 400 HOH A O   1 
HETATM 3250 O O   . HOH D 4 .   ? -0.439  -44.689 28.398  1.00 27.45 ? 401 HOH A O   1 
HETATM 3251 O O   . HOH D 4 .   ? -24.039 -47.155 19.301  1.00 22.36 ? 402 HOH A O   1 
HETATM 3252 O O   . HOH D 4 .   ? -31.666 -23.638 15.348  1.00 19.25 ? 403 HOH A O   1 
HETATM 3253 O O   . HOH D 4 .   ? -23.581 -18.802 5.903   1.00 16.24 ? 404 HOH A O   1 
HETATM 3254 O O   . HOH D 4 .   ? -3.459  -45.308 14.818  1.00 28.41 ? 405 HOH A O   1 
HETATM 3255 O O   . HOH D 4 .   ? 1.575   -38.771 26.171  1.00 25.88 ? 406 HOH A O   1 
HETATM 3256 O O   . HOH D 4 .   ? -47.301 -20.834 6.339   1.00 33.09 ? 407 HOH A O   1 
HETATM 3257 O O   . HOH D 4 .   ? -17.084 -39.805 6.407   1.00 16.70 ? 408 HOH A O   1 
HETATM 3258 O O   . HOH D 4 .   ? -25.392 -9.099  7.193   1.00 37.95 ? 409 HOH A O   1 
HETATM 3259 O O   . HOH D 4 .   ? -17.402 -34.531 9.805   1.00 15.94 ? 410 HOH A O   1 
HETATM 3260 O O   . HOH D 4 .   ? -5.145  -46.045 3.379   1.00 46.97 ? 411 HOH A O   1 
HETATM 3261 O O   . HOH D 4 .   ? -29.063 -13.851 5.616   1.00 27.61 ? 412 HOH A O   1 
HETATM 3262 O O   . HOH D 4 .   ? -3.484  -26.864 2.012   1.00 26.72 ? 413 HOH A O   1 
HETATM 3263 O O   . HOH D 4 .   ? -18.818 -12.451 17.454  1.00 39.06 ? 414 HOH A O   1 
HETATM 3264 O O   . HOH D 4 .   ? -22.612 -21.017 0.340   1.00 33.23 ? 415 HOH A O   1 
HETATM 3265 O O   . HOH D 4 .   ? -38.023 -2.767  19.272  1.00 35.84 ? 416 HOH A O   1 
HETATM 3266 O O   . HOH D 4 .   ? -14.166 -16.669 7.721   1.00 37.10 ? 417 HOH A O   1 
HETATM 3267 O O   . HOH D 4 .   ? -35.926 -18.952 18.629  1.00 21.53 ? 418 HOH A O   1 
HETATM 3268 O O   . HOH D 4 .   ? -5.854  -48.193 10.439  1.00 26.11 ? 419 HOH A O   1 
HETATM 3269 O O   . HOH D 4 .   ? -8.797  -33.024 1.739   1.00 17.88 ? 420 HOH A O   1 
HETATM 3270 O O   . HOH D 4 .   ? 0.486   -28.081 16.627  1.00 37.64 ? 421 HOH A O   1 
HETATM 3271 O O   . HOH D 4 .   ? -38.201 -7.947  23.324  1.00 29.46 ? 422 HOH A O   1 
HETATM 3272 O O   . HOH D 4 .   ? -26.520 -40.369 22.506  1.00 27.75 ? 423 HOH A O   1 
HETATM 3273 O O   . HOH D 4 .   ? -9.662  -53.980 25.038  1.00 39.12 ? 424 HOH A O   1 
HETATM 3274 O O   . HOH D 4 .   ? -21.053 -36.892 24.243  1.00 33.65 ? 425 HOH A O   1 
HETATM 3275 O O   . HOH D 4 .   ? 1.287   -21.408 3.229   1.00 32.35 ? 426 HOH A O   1 
HETATM 3276 O O   . HOH D 4 .   ? -10.824 -53.139 29.112  1.00 26.23 ? 427 HOH A O   1 
HETATM 3277 O O   . HOH D 4 .   ? -18.587 -21.033 7.889   1.00 21.05 ? 428 HOH A O   1 
HETATM 3278 O O   . HOH D 4 .   ? -13.113 -28.932 30.847  1.00 28.94 ? 429 HOH A O   1 
HETATM 3279 O O   . HOH D 4 .   ? -18.627 -35.044 28.874  1.00 23.56 ? 430 HOH A O   1 
HETATM 3280 O O   . HOH D 4 .   ? -9.015  -50.047 34.627  1.00 33.10 ? 431 HOH A O   1 
HETATM 3281 O O   . HOH D 4 .   ? -8.814  -10.136 10.529  1.00 32.73 ? 432 HOH A O   1 
HETATM 3282 O O   . HOH D 4 .   ? -2.183  -28.314 0.278   1.00 24.92 ? 433 HOH A O   1 
HETATM 3283 O O   . HOH D 4 .   ? -21.486 -23.889 14.302  1.00 35.41 ? 434 HOH A O   1 
HETATM 3284 O O   . HOH D 4 .   ? -42.722 -3.139  14.544  1.00 29.39 ? 435 HOH A O   1 
HETATM 3285 O O   . HOH D 4 .   ? -2.909  -21.805 27.072  1.00 29.74 ? 436 HOH A O   1 
HETATM 3286 O O   . HOH D 4 .   ? -15.929 -49.044 32.733  1.00 33.83 ? 437 HOH A O   1 
HETATM 3287 O O   . HOH D 4 .   ? -24.952 -46.788 8.860   1.00 27.78 ? 438 HOH A O   1 
HETATM 3288 O O   . HOH D 4 .   ? -22.706 -17.624 20.067  1.00 31.68 ? 439 HOH A O   1 
HETATM 3289 O O   . HOH D 4 .   ? -11.771 -24.444 -0.797  1.00 28.56 ? 440 HOH A O   1 
HETATM 3290 O O   . HOH D 4 .   ? -2.440  -43.331 13.062  1.00 24.07 ? 441 HOH A O   1 
HETATM 3291 O O   . HOH D 4 .   ? -25.047 -52.059 27.272  1.00 30.87 ? 442 HOH A O   1 
HETATM 3292 O O   . HOH D 4 .   ? -0.612  -18.081 22.727  1.00 36.00 ? 443 HOH A O   1 
HETATM 3293 O O   . HOH D 4 .   ? -32.570 -20.768 17.825  1.00 26.95 ? 444 HOH A O   1 
HETATM 3294 O O   . HOH D 4 .   ? -36.685 -25.243 15.695  1.00 33.70 ? 445 HOH A O   1 
HETATM 3295 O O   . HOH D 4 .   ? -6.830  -20.721 -0.947  1.00 39.62 ? 446 HOH A O   1 
HETATM 3296 O O   . HOH D 4 .   ? -25.829 -37.390 22.899  1.00 36.68 ? 447 HOH A O   1 
HETATM 3297 O O   . HOH D 4 .   ? -36.528 -26.689 10.518  1.00 24.28 ? 448 HOH A O   1 
HETATM 3298 O O   . HOH D 4 .   ? -18.854 -15.312 17.753  1.00 30.78 ? 449 HOH A O   1 
HETATM 3299 O O   . HOH D 4 .   ? -22.256 -32.036 29.951  1.00 48.94 ? 450 HOH A O   1 
HETATM 3300 O O   . HOH D 4 .   ? -53.746 -5.626  25.778  1.00 39.54 ? 451 HOH A O   1 
HETATM 3301 O O   . HOH D 4 .   ? -47.541 -21.642 10.519  1.00 32.77 ? 452 HOH A O   1 
HETATM 3302 O O   . HOH D 4 .   ? -12.361 -55.110 30.029  1.00 41.11 ? 453 HOH A O   1 
HETATM 3303 O O   . HOH D 4 .   ? -2.839  -24.112 1.930   1.00 27.31 ? 454 HOH A O   1 
HETATM 3304 O O   . HOH D 4 .   ? -20.557 -21.966 1.391   1.00 37.24 ? 455 HOH A O   1 
HETATM 3305 O O   . HOH D 4 .   ? -2.857  -49.682 30.777  1.00 29.87 ? 456 HOH A O   1 
HETATM 3306 O O   . HOH D 4 .   ? -20.362 -46.631 32.909  1.00 27.66 ? 457 HOH A O   1 
HETATM 3307 O O   . HOH D 4 .   ? -19.466 -25.390 16.965  1.00 30.40 ? 458 HOH A O   1 
HETATM 3308 O O   . HOH D 4 .   ? -2.419  -27.974 31.397  1.00 34.59 ? 459 HOH A O   1 
HETATM 3309 O O   . HOH D 4 .   ? -47.872 -21.764 12.724  1.00 29.94 ? 460 HOH A O   1 
HETATM 3310 O O   . HOH D 4 .   ? -17.340 -11.606 18.991  1.00 35.09 ? 461 HOH A O   1 
HETATM 3311 O O   . HOH D 4 .   ? -24.690 -21.021 19.402  1.00 41.44 ? 462 HOH A O   1 
HETATM 3312 O O   . HOH D 4 .   ? -37.554 -27.685 12.663  1.00 37.10 ? 463 HOH A O   1 
HETATM 3313 O O   . HOH D 4 .   ? -28.388 -14.163 22.033  1.00 30.47 ? 464 HOH A O   1 
HETATM 3314 O O   . HOH D 4 .   ? -20.751 -27.116 18.475  1.00 32.33 ? 465 HOH A O   1 
HETATM 3315 O O   . HOH D 4 .   ? -14.851 -51.560 9.670   1.00 30.35 ? 466 HOH A O   1 
HETATM 3316 O O   . HOH D 4 .   ? -20.154 -17.007 19.484  1.00 31.45 ? 467 HOH A O   1 
HETATM 3317 O O   . HOH D 4 .   ? -6.024  -51.969 30.324  1.00 34.96 ? 468 HOH A O   1 
HETATM 3318 O O   . HOH D 4 .   ? -0.282  -42.526 38.596  1.00 35.53 ? 469 HOH A O   1 
HETATM 3319 O O   . HOH D 4 .   ? -21.529 -36.552 26.971  1.00 33.90 ? 470 HOH A O   1 
HETATM 3320 O O   . HOH D 4 .   ? -22.194 -20.736 7.059   1.00 23.37 ? 471 HOH A O   1 
HETATM 3321 O O   . HOH D 4 .   ? -50.931 -22.657 8.232   1.00 39.03 ? 472 HOH A O   1 
HETATM 3322 O O   . HOH D 4 .   ? -14.676 -51.711 6.468   1.00 34.61 ? 473 HOH A O   1 
HETATM 3323 O O   . HOH D 4 .   ? -26.235 -22.928 13.327  1.00 32.93 ? 474 HOH A O   1 
HETATM 3324 O O   . HOH D 4 .   ? -23.386 -20.637 21.929  1.00 41.22 ? 475 HOH A O   1 
HETATM 3325 O O   . HOH D 4 .   ? -52.347 -23.195 6.057   1.00 44.81 ? 476 HOH A O   1 
HETATM 3326 O O   . HOH E 4 .   ? -27.999 -16.883 -12.679 1.00 38.18 ? 101 HOH B O   1 
HETATM 3327 O O   . HOH E 4 .   ? -31.235 -32.660 15.958  1.00 32.31 ? 102 HOH B O   1 
HETATM 3328 O O   . HOH E 4 .   ? -37.519 -35.358 5.845   1.00 27.33 ? 103 HOH B O   1 
HETATM 3329 O O   . HOH E 4 .   ? -28.076 -37.031 -7.862  1.00 35.43 ? 104 HOH B O   1 
HETATM 3330 O O   . HOH E 4 .   ? -26.444 -32.289 -5.567  1.00 31.82 ? 105 HOH B O   1 
HETATM 3331 O O   . HOH E 4 .   ? -24.620 -38.125 -1.946  1.00 34.75 ? 106 HOH B O   1 
HETATM 3332 O O   . HOH E 4 .   ? -35.051 -18.710 -12.768 1.00 29.09 ? 107 HOH B O   1 
HETATM 3333 O O   . HOH E 4 .   ? -29.242 -42.749 3.369   1.00 20.02 ? 108 HOH B O   1 
HETATM 3334 O O   . HOH E 4 .   ? -23.330 -32.640 -11.526 1.00 45.56 ? 109 HOH B O   1 
HETATM 3335 O O   . HOH E 4 .   ? -38.442 -18.581 -10.137 1.00 31.37 ? 110 HOH B O   1 
HETATM 3336 O O   . HOH E 4 .   ? -23.189 -37.565 3.098   1.00 25.00 ? 111 HOH B O   1 
HETATM 3337 O O   . HOH E 4 .   ? -36.390 -34.392 -14.095 1.00 39.07 ? 112 HOH B O   1 
HETATM 3338 O O   . HOH E 4 .   ? -28.132 -31.420 12.806  1.00 14.13 ? 113 HOH B O   1 
HETATM 3339 O O   . HOH E 4 .   ? -31.861 -21.096 -13.029 1.00 33.75 ? 114 HOH B O   1 
HETATM 3340 O O   . HOH E 4 .   ? -22.149 -28.951 6.311   1.00 17.19 ? 115 HOH B O   1 
HETATM 3341 O O   . HOH E 4 .   ? -25.506 -20.213 -0.519  1.00 17.80 ? 116 HOH B O   1 
HETATM 3342 O O   . HOH E 4 .   ? -32.008 -36.365 -4.811  1.00 20.29 ? 117 HOH B O   1 
HETATM 3343 O O   . HOH E 4 .   ? -17.708 -29.692 0.311   1.00 25.55 ? 118 HOH B O   1 
HETATM 3344 O O   . HOH E 4 .   ? -40.771 -38.700 1.174   1.00 21.54 ? 119 HOH B O   1 
HETATM 3345 O O   . HOH E 4 .   ? -34.971 -44.549 0.503   1.00 24.96 ? 120 HOH B O   1 
HETATM 3346 O O   . HOH E 4 .   ? -34.745 -43.367 -3.560  1.00 15.43 ? 121 HOH B O   1 
HETATM 3347 O O   . HOH E 4 .   ? -22.967 -42.128 8.353   1.00 19.71 ? 122 HOH B O   1 
HETATM 3348 O O   . HOH E 4 .   ? -15.772 -32.177 2.115   1.00 30.75 ? 123 HOH B O   1 
HETATM 3349 O O   . HOH E 4 .   ? -39.760 -9.501  -4.351  1.00 24.83 ? 124 HOH B O   1 
HETATM 3350 O O   . HOH E 4 .   ? -25.198 -28.287 17.720  1.00 31.16 ? 125 HOH B O   1 
HETATM 3351 O O   . HOH E 4 .   ? -30.143 -12.279 3.199   1.00 39.44 ? 126 HOH B O   1 
HETATM 3352 O O   . HOH E 4 .   ? -40.413 -38.883 -4.605  1.00 14.43 ? 127 HOH B O   1 
HETATM 3353 O O   . HOH E 4 .   ? -39.333 -22.276 0.641   1.00 19.90 ? 128 HOH B O   1 
HETATM 3354 O O   . HOH E 4 .   ? -33.832 -27.243 9.203   1.00 25.24 ? 129 HOH B O   1 
HETATM 3355 O O   . HOH E 4 .   ? -34.192 -19.027 -16.120 1.00 34.54 ? 130 HOH B O   1 
HETATM 3356 O O   . HOH E 4 .   ? -28.722 -9.571  -11.108 1.00 31.20 ? 131 HOH B O   1 
HETATM 3357 O O   . HOH E 4 .   ? -28.771 -30.870 -8.345  1.00 19.54 ? 132 HOH B O   1 
HETATM 3358 O O   . HOH E 4 .   ? -43.404 -31.514 -3.719  1.00 29.93 ? 133 HOH B O   1 
HETATM 3359 O O   . HOH E 4 .   ? -39.385 -26.862 4.580   1.00 25.31 ? 134 HOH B O   1 
HETATM 3360 O O   . HOH E 4 .   ? -40.625 -24.391 1.112   1.00 22.12 ? 135 HOH B O   1 
HETATM 3361 O O   . HOH E 4 .   ? -33.181 -12.330 -6.357  1.00 21.99 ? 136 HOH B O   1 
HETATM 3362 O O   . HOH E 4 .   ? -34.560 -16.823 2.602   1.00 28.70 ? 137 HOH B O   1 
HETATM 3363 O O   . HOH E 4 .   ? -42.179 -35.316 -1.912  1.00 22.39 ? 138 HOH B O   1 
HETATM 3364 O O   . HOH E 4 .   ? -39.969 -12.731 3.200   1.00 18.92 ? 139 HOH B O   1 
HETATM 3365 O O   . HOH E 4 .   ? -21.588 -40.265 4.067   1.00 29.44 ? 140 HOH B O   1 
HETATM 3366 O O   . HOH E 4 .   ? -39.842 -10.311 -7.996  1.00 28.07 ? 141 HOH B O   1 
HETATM 3367 O O   . HOH E 4 .   ? -43.616 -18.344 -3.394  1.00 28.63 ? 142 HOH B O   1 
HETATM 3368 O O   . HOH E 4 .   ? -35.562 -41.216 -0.169  1.00 15.76 ? 143 HOH B O   1 
HETATM 3369 O O   . HOH E 4 .   ? -26.181 -35.356 -3.349  1.00 26.35 ? 144 HOH B O   1 
HETATM 3370 O O   . HOH E 4 .   ? -38.397 -13.588 1.316   1.00 28.73 ? 145 HOH B O   1 
HETATM 3371 O O   . HOH E 4 .   ? -40.455 -22.244 -6.919  1.00 22.92 ? 146 HOH B O   1 
HETATM 3372 O O   . HOH E 4 .   ? -37.356 -15.261 -1.430  1.00 23.36 ? 147 HOH B O   1 
HETATM 3373 O O   . HOH E 4 .   ? -38.730 -27.957 -9.750  1.00 23.15 ? 148 HOH B O   1 
HETATM 3374 O O   . HOH E 4 .   ? -37.702 -37.024 -8.918  1.00 31.26 ? 149 HOH B O   1 
HETATM 3375 O O   . HOH E 4 .   ? -41.639 -25.644 -7.082  1.00 27.39 ? 150 HOH B O   1 
HETATM 3376 O O   . HOH E 4 .   ? -38.490 -25.071 2.918   1.00 18.18 ? 151 HOH B O   1 
HETATM 3377 O O   . HOH E 4 .   ? -36.549 -44.685 -1.612  1.00 23.17 ? 152 HOH B O   1 
HETATM 3378 O O   . HOH E 4 .   ? -25.416 -13.967 -7.031  1.00 32.05 ? 153 HOH B O   1 
HETATM 3379 O O   . HOH E 4 .   ? -38.357 -23.342 6.061   1.00 25.91 ? 154 HOH B O   1 
HETATM 3380 O O   . HOH E 4 .   ? -18.571 -33.556 2.677   1.00 28.03 ? 155 HOH B O   1 
HETATM 3381 O O   . HOH E 4 .   ? -23.834 -31.500 -4.930  1.00 32.36 ? 156 HOH B O   1 
HETATM 3382 O O   . HOH E 4 .   ? -23.658 -43.117 6.129   1.00 28.18 ? 157 HOH B O   1 
HETATM 3383 O O   . HOH E 4 .   ? -25.497 -24.600 10.109  1.00 25.52 ? 158 HOH B O   1 
HETATM 3384 O O   . HOH E 4 .   ? -41.731 -41.185 2.000   1.00 34.04 ? 159 HOH B O   1 
HETATM 3385 O O   . HOH E 4 .   ? -36.346 -39.135 12.842  1.00 30.42 ? 160 HOH B O   1 
HETATM 3386 O O   . HOH E 4 .   ? -30.568 -18.795 -13.322 1.00 30.13 ? 161 HOH B O   1 
HETATM 3387 O O   . HOH E 4 .   ? -34.328 -27.060 -16.108 1.00 36.34 ? 162 HOH B O   1 
HETATM 3388 O O   . HOH E 4 .   ? -19.253 -29.157 -3.523  1.00 22.69 ? 163 HOH B O   1 
HETATM 3389 O O   . HOH E 4 .   ? -35.916 -25.047 -17.124 1.00 36.03 ? 164 HOH B O   1 
HETATM 3390 O O   . HOH E 4 .   ? -38.322 -29.707 7.733   1.00 31.64 ? 165 HOH B O   1 
HETATM 3391 O O   . HOH E 4 .   ? -23.268 -26.117 6.467   1.00 31.11 ? 166 HOH B O   1 
HETATM 3392 O O   . HOH E 4 .   ? -42.854 -37.427 -0.362  1.00 29.42 ? 167 HOH B O   1 
HETATM 3393 O O   . HOH E 4 .   ? -23.457 -39.161 1.109   1.00 34.24 ? 168 HOH B O   1 
HETATM 3394 O O   . HOH E 4 .   ? -27.872 -19.138 -13.483 1.00 40.99 ? 169 HOH B O   1 
HETATM 3395 O O   . HOH E 4 .   ? -41.315 -27.529 -8.719  1.00 33.56 ? 170 HOH B O   1 
HETATM 3396 O O   . HOH E 4 .   ? -21.014 -25.999 14.727  1.00 30.63 ? 171 HOH B O   1 
HETATM 3397 O O   . HOH E 4 .   ? -38.291 -27.119 8.493   1.00 29.91 ? 172 HOH B O   1 
HETATM 3398 O O   . HOH E 4 .   ? -27.439 -10.558 -12.672 1.00 42.68 ? 173 HOH B O   1 
HETATM 3399 O O   . HOH E 4 .   ? -22.599 -23.965 5.498   1.00 33.72 ? 174 HOH B O   1 
HETATM 3400 O O   . HOH E 4 .   ? -24.453 -24.574 13.371  1.00 34.91 ? 175 HOH B O   1 
HETATM 3401 O O   . HOH E 4 .   ? -30.312 -23.372 -12.646 1.00 34.06 ? 176 HOH B O   1 
HETATM 3402 O O   . HOH E 4 .   ? -39.800 -25.055 6.642   1.00 25.36 ? 177 HOH B O   1 
HETATM 3403 O O   . HOH E 4 .   ? -28.030 -45.230 3.938   1.00 33.92 ? 178 HOH B O   1 
HETATM 3404 O O   . HOH E 4 .   ? -30.065 -25.176 -14.582 1.00 36.06 ? 179 HOH B O   1 
HETATM 3405 O O   . HOH E 4 .   ? -41.733 -28.383 4.182   1.00 33.71 ? 180 HOH B O   1 
HETATM 3406 O O   . HOH E 4 .   ? -43.443 -32.751 -6.177  1.00 41.87 ? 181 HOH B O   1 
HETATM 3407 O O   . HOH F 4 .   ? 1.368   -40.529 12.334  1.00 26.32 ? 101 HOH E O   1 
HETATM 3408 O O   . HOH F 4 .   ? -4.577  -36.917 15.040  1.00 16.38 ? 102 HOH E O   1 
HETATM 3409 O O   . HOH F 4 .   ? 1.864   -33.888 11.723  1.00 27.02 ? 103 HOH E O   1 
HETATM 3410 O O   . HOH F 4 .   ? -1.177  -23.461 19.048  1.00 30.16 ? 104 HOH E O   1 
HETATM 3411 O O   . HOH F 4 .   ? -8.314  -34.135 21.335  1.00 16.91 ? 105 HOH E O   1 
HETATM 3412 O O   . HOH F 4 .   ? -1.384  -32.323 19.695  1.00 24.56 ? 106 HOH E O   1 
HETATM 3413 O O   . HOH F 4 .   ? -1.681  -36.989 21.740  1.00 22.54 ? 107 HOH E O   1 
HETATM 3414 O O   . HOH F 4 .   ? -2.572  -46.201 16.872  1.00 25.04 ? 108 HOH E O   1 
HETATM 3415 O O   . HOH F 4 .   ? -1.542  -34.490 22.555  1.00 18.03 ? 109 HOH E O   1 
HETATM 3416 O O   . HOH F 4 .   ? -3.130  -40.066 21.123  1.00 19.95 ? 110 HOH E O   1 
HETATM 3417 O O   . HOH F 4 .   ? -6.458  -40.542 20.694  1.00 28.11 ? 111 HOH E O   1 
HETATM 3418 O O   . HOH F 4 .   ? -1.428  -46.310 21.243  1.00 32.82 ? 112 HOH E O   1 
HETATM 3419 O O   . HOH F 4 .   ? -2.027  -48.522 17.151  1.00 32.39 ? 113 HOH E O   1 
# 
