data_8YZR
# 
_entry.id   8YZR 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YZR         pdb_00008yzr 10.2210/pdb8yzr/pdb 
WWPDB D_1300046690 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-29 ? 
2 'Structure model' 1 1 2025-05-28 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 2 'Structure model' 'Structure summary'   
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' struct          
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
12 2 'Structure model' '_struct.title'                     
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YZR 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              liujun@ivdc.chinacdc.cn 
_pdbx_contact_author.name_first         Jun 
_pdbx_contact_author.name_last          Liu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3605-4070 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Min, L.' 1 ? 
'Liu, J.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nat.Immunol. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1529-2916 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            26 
_citation.language                  ? 
_citation.page_first                265 
_citation.page_last                 278 
_citation.title                     
'T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41590-024-02051-0 
_citation.pdbx_database_id_PubMed   39875585 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tian, J.'  1  ?                   
primary 'Shang, B.' 2  ?                   
primary 'Zhang, J.' 3  ?                   
primary 'Guo, Y.'   4  0009-0002-7712-6050 
primary 'Li, M.'    5  ?                   
primary 'Hu, Y.'    6  ?                   
primary 'Bai, D.'   7  ?                   
primary 'She, J.'   8  ?                   
primary 'Han, Y.'   9  ?                   
primary 'Guo, P.'   10 ?                   
primary 'Huang, M.' 11 ?                   
primary 'Wang, Y.'  12 ?                   
primary 'Liu, M.'   13 ?                   
primary 'Zhang, J.' 14 ?                   
primary 'Ye, B.'    15 ?                   
primary 'Guo, Y.'   16 ?                   
primary 'Yang, M.'  17 ?                   
primary 'Lin, Y.'   18 ?                   
primary 'Zhang, T.' 19 ?                   
primary 'Sun, X.'   20 ?                   
primary 'Yuan, X.'  21 ?                   
primary 'Zhang, D.' 22 ?                   
primary 'Xu, Z.'    23 ?                   
primary 'Chai, Y.'  24 ?                   
primary 'Qi, J.'    25 0000-0002-9358-4732 
primary 'Liu, K.'   26 0000-0001-9076-2647 
primary 'Tan, S.'   27 0000-0002-2599-4959 
primary 'Zhao, Y.'  28 0000-0002-3370-6398 
primary 'Zhou, J.'  29 0009-0000-4884-5780 
primary 'Song, R.'  30 0000-0003-3624-2514 
primary 'Gao, G.F.' 31 0000-0002-3869-615X 
primary 'Liu, J.'   32 0000-0003-3605-4070 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'MHC class I antigen' 31551.889 1   ? ? ? ? 
2 polymer man Beta-2-microglobulin  11748.160 1   ? ? ? ? 
3 polymer syn 'Spike protein S1'    1232.409  1   ? ? ? ? 
4 water   nat water                 18.015    286 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'HLA class I heavy chain'           
3 ASN-TYR-ASN-TYR-LEU-TYR-ARG-LEU-PHE 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDEETGKVKAHSQTDRENLRI
ALRYYNQSEAGSHTLQMMFGCDVGSDGRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQITKRKWEAAHVAEQQRAYL
EGTCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW
;
;GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDEETGKVKAHSQTDRENLRI
ALRYYNQSEAGSHTLQMMFGCDVGSDGRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQITKRKWEAAHVAEQQRAYL
EGTCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW
;
A ? 
2 'polypeptide(L)' no no 
;IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM
;
;IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM
;
B ? 
3 'polypeptide(L)' no no NYNYLYRLL NYNYLYRLL E ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   HIS n 
1 4   SER n 
1 5   MET n 
1 6   ARG n 
1 7   TYR n 
1 8   PHE n 
1 9   SER n 
1 10  THR n 
1 11  SER n 
1 12  VAL n 
1 13  SER n 
1 14  ARG n 
1 15  PRO n 
1 16  GLY n 
1 17  ARG n 
1 18  GLY n 
1 19  GLU n 
1 20  PRO n 
1 21  ARG n 
1 22  PHE n 
1 23  ILE n 
1 24  ALA n 
1 25  VAL n 
1 26  GLY n 
1 27  TYR n 
1 28  VAL n 
1 29  ASP n 
1 30  ASP n 
1 31  THR n 
1 32  GLN n 
1 33  PHE n 
1 34  VAL n 
1 35  ARG n 
1 36  PHE n 
1 37  ASP n 
1 38  SER n 
1 39  ASP n 
1 40  ALA n 
1 41  ALA n 
1 42  SER n 
1 43  GLN n 
1 44  ARG n 
1 45  MET n 
1 46  GLU n 
1 47  PRO n 
1 48  ARG n 
1 49  ALA n 
1 50  PRO n 
1 51  TRP n 
1 52  ILE n 
1 53  GLU n 
1 54  GLN n 
1 55  GLU n 
1 56  GLY n 
1 57  PRO n 
1 58  GLU n 
1 59  TYR n 
1 60  TRP n 
1 61  ASP n 
1 62  GLU n 
1 63  GLU n 
1 64  THR n 
1 65  GLY n 
1 66  LYS n 
1 67  VAL n 
1 68  LYS n 
1 69  ALA n 
1 70  HIS n 
1 71  SER n 
1 72  GLN n 
1 73  THR n 
1 74  ASP n 
1 75  ARG n 
1 76  GLU n 
1 77  ASN n 
1 78  LEU n 
1 79  ARG n 
1 80  ILE n 
1 81  ALA n 
1 82  LEU n 
1 83  ARG n 
1 84  TYR n 
1 85  TYR n 
1 86  ASN n 
1 87  GLN n 
1 88  SER n 
1 89  GLU n 
1 90  ALA n 
1 91  GLY n 
1 92  SER n 
1 93  HIS n 
1 94  THR n 
1 95  LEU n 
1 96  GLN n 
1 97  MET n 
1 98  MET n 
1 99  PHE n 
1 100 GLY n 
1 101 CYS n 
1 102 ASP n 
1 103 VAL n 
1 104 GLY n 
1 105 SER n 
1 106 ASP n 
1 107 GLY n 
1 108 ARG n 
1 109 PHE n 
1 110 LEU n 
1 111 ARG n 
1 112 GLY n 
1 113 TYR n 
1 114 HIS n 
1 115 GLN n 
1 116 TYR n 
1 117 ALA n 
1 118 TYR n 
1 119 ASP n 
1 120 GLY n 
1 121 LYS n 
1 122 ASP n 
1 123 TYR n 
1 124 ILE n 
1 125 ALA n 
1 126 LEU n 
1 127 LYS n 
1 128 GLU n 
1 129 ASP n 
1 130 LEU n 
1 131 ARG n 
1 132 SER n 
1 133 TRP n 
1 134 THR n 
1 135 ALA n 
1 136 ALA n 
1 137 ASP n 
1 138 MET n 
1 139 ALA n 
1 140 ALA n 
1 141 GLN n 
1 142 ILE n 
1 143 THR n 
1 144 LYS n 
1 145 ARG n 
1 146 LYS n 
1 147 TRP n 
1 148 GLU n 
1 149 ALA n 
1 150 ALA n 
1 151 HIS n 
1 152 VAL n 
1 153 ALA n 
1 154 GLU n 
1 155 GLN n 
1 156 GLN n 
1 157 ARG n 
1 158 ALA n 
1 159 TYR n 
1 160 LEU n 
1 161 GLU n 
1 162 GLY n 
1 163 THR n 
1 164 CYS n 
1 165 VAL n 
1 166 ASP n 
1 167 GLY n 
1 168 LEU n 
1 169 ARG n 
1 170 ARG n 
1 171 TYR n 
1 172 LEU n 
1 173 GLU n 
1 174 ASN n 
1 175 GLY n 
1 176 LYS n 
1 177 GLU n 
1 178 THR n 
1 179 LEU n 
1 180 GLN n 
1 181 ARG n 
1 182 THR n 
1 183 ASP n 
1 184 PRO n 
1 185 PRO n 
1 186 LYS n 
1 187 THR n 
1 188 HIS n 
1 189 MET n 
1 190 THR n 
1 191 HIS n 
1 192 HIS n 
1 193 PRO n 
1 194 ILE n 
1 195 SER n 
1 196 ASP n 
1 197 HIS n 
1 198 GLU n 
1 199 ALA n 
1 200 THR n 
1 201 LEU n 
1 202 ARG n 
1 203 CYS n 
1 204 TRP n 
1 205 ALA n 
1 206 LEU n 
1 207 GLY n 
1 208 PHE n 
1 209 TYR n 
1 210 PRO n 
1 211 ALA n 
1 212 GLU n 
1 213 ILE n 
1 214 THR n 
1 215 LEU n 
1 216 THR n 
1 217 TRP n 
1 218 GLN n 
1 219 ARG n 
1 220 ASP n 
1 221 GLY n 
1 222 GLU n 
1 223 ASP n 
1 224 GLN n 
1 225 THR n 
1 226 GLN n 
1 227 ASP n 
1 228 THR n 
1 229 GLU n 
1 230 LEU n 
1 231 VAL n 
1 232 GLU n 
1 233 THR n 
1 234 ARG n 
1 235 PRO n 
1 236 ALA n 
1 237 GLY n 
1 238 ASP n 
1 239 GLY n 
1 240 THR n 
1 241 PHE n 
1 242 GLN n 
1 243 LYS n 
1 244 TRP n 
1 245 ALA n 
1 246 ALA n 
1 247 VAL n 
1 248 VAL n 
1 249 VAL n 
1 250 PRO n 
1 251 SER n 
1 252 GLY n 
1 253 GLU n 
1 254 GLU n 
1 255 GLN n 
1 256 ARG n 
1 257 TYR n 
1 258 THR n 
1 259 CYS n 
1 260 HIS n 
1 261 VAL n 
1 262 GLN n 
1 263 HIS n 
1 264 GLU n 
1 265 GLY n 
1 266 LEU n 
1 267 PRO n 
1 268 LYS n 
1 269 PRO n 
1 270 LEU n 
1 271 THR n 
1 272 LEU n 
1 273 ARG n 
1 274 TRP n 
2 1   ILE n 
2 2   GLN n 
2 3   ARG n 
2 4   THR n 
2 5   PRO n 
2 6   LYS n 
2 7   ILE n 
2 8   GLN n 
2 9   VAL n 
2 10  TYR n 
2 11  SER n 
2 12  ARG n 
2 13  HIS n 
2 14  PRO n 
2 15  ALA n 
2 16  GLU n 
2 17  ASN n 
2 18  GLY n 
2 19  LYS n 
2 20  SER n 
2 21  ASN n 
2 22  PHE n 
2 23  LEU n 
2 24  ASN n 
2 25  CYS n 
2 26  TYR n 
2 27  VAL n 
2 28  SER n 
2 29  GLY n 
2 30  PHE n 
2 31  HIS n 
2 32  PRO n 
2 33  SER n 
2 34  ASP n 
2 35  ILE n 
2 36  GLU n 
2 37  VAL n 
2 38  ASP n 
2 39  LEU n 
2 40  LEU n 
2 41  LYS n 
2 42  ASN n 
2 43  GLY n 
2 44  GLU n 
2 45  ARG n 
2 46  ILE n 
2 47  GLU n 
2 48  LYS n 
2 49  VAL n 
2 50  GLU n 
2 51  HIS n 
2 52  SER n 
2 53  ASP n 
2 54  LEU n 
2 55  SER n 
2 56  PHE n 
2 57  SER n 
2 58  LYS n 
2 59  ASP n 
2 60  TRP n 
2 61  SER n 
2 62  PHE n 
2 63  TYR n 
2 64  LEU n 
2 65  LEU n 
2 66  TYR n 
2 67  TYR n 
2 68  THR n 
2 69  GLU n 
2 70  PHE n 
2 71  THR n 
2 72  PRO n 
2 73  THR n 
2 74  GLU n 
2 75  LYS n 
2 76  ASP n 
2 77  GLU n 
2 78  TYR n 
2 79  ALA n 
2 80  CYS n 
2 81  ARG n 
2 82  VAL n 
2 83  ASN n 
2 84  HIS n 
2 85  VAL n 
2 86  THR n 
2 87  LEU n 
2 88  SER n 
2 89  GLN n 
2 90  PRO n 
2 91  LYS n 
2 92  ILE n 
2 93  VAL n 
2 94  LYS n 
2 95  TRP n 
2 96  ASP n 
2 97  ARG n 
2 98  ASP n 
2 99  MET n 
3 1   ASN n 
3 2   TYR n 
3 3   ASN n 
3 4   TYR n 
3 5   LEU n 
3 6   TYR n 
3 7   ARG n 
3 8   LEU n 
3 9   LEU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 274 human ? HLA-A                      ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 99  human ? 'B2M, CDABP0092, HDCMA22P' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_src_syn.entity_id              3 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       9 
_pdbx_entity_src_syn.organism_scientific    'Severe acute respiratory syndrome coronavirus 2' 
_pdbx_entity_src_syn.organism_common_name   '2019-nCoV, SARS-CoV-2' 
_pdbx_entity_src_syn.ncbi_taxonomy_id       2697049 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   1   1   GLY GLY A . n 
A 1 2   SER 2   2   2   SER SER A . n 
A 1 3   HIS 3   3   3   HIS HIS A . n 
A 1 4   SER 4   4   4   SER SER A . n 
A 1 5   MET 5   5   5   MET MET A . n 
A 1 6   ARG 6   6   6   ARG ARG A . n 
A 1 7   TYR 7   7   7   TYR TYR A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   SER 9   9   9   SER SER A . n 
A 1 10  THR 10  10  10  THR THR A . n 
A 1 11  SER 11  11  11  SER SER A . n 
A 1 12  VAL 12  12  12  VAL VAL A . n 
A 1 13  SER 13  13  13  SER SER A . n 
A 1 14  ARG 14  14  14  ARG ARG A . n 
A 1 15  PRO 15  15  15  PRO PRO A . n 
A 1 16  GLY 16  16  16  GLY GLY A . n 
A 1 17  ARG 17  17  17  ARG ARG A . n 
A 1 18  GLY 18  18  18  GLY GLY A . n 
A 1 19  GLU 19  19  19  GLU GLU A . n 
A 1 20  PRO 20  20  20  PRO PRO A . n 
A 1 21  ARG 21  21  21  ARG ARG A . n 
A 1 22  PHE 22  22  22  PHE PHE A . n 
A 1 23  ILE 23  23  23  ILE ILE A . n 
A 1 24  ALA 24  24  24  ALA ALA A . n 
A 1 25  VAL 25  25  25  VAL VAL A . n 
A 1 26  GLY 26  26  26  GLY GLY A . n 
A 1 27  TYR 27  27  27  TYR TYR A . n 
A 1 28  VAL 28  28  28  VAL VAL A . n 
A 1 29  ASP 29  29  29  ASP ASP A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  THR 31  31  31  THR THR A . n 
A 1 32  GLN 32  32  32  GLN GLN A . n 
A 1 33  PHE 33  33  33  PHE PHE A . n 
A 1 34  VAL 34  34  34  VAL VAL A . n 
A 1 35  ARG 35  35  35  ARG ARG A . n 
A 1 36  PHE 36  36  36  PHE PHE A . n 
A 1 37  ASP 37  37  37  ASP ASP A . n 
A 1 38  SER 38  38  38  SER SER A . n 
A 1 39  ASP 39  39  39  ASP ASP A . n 
A 1 40  ALA 40  40  40  ALA ALA A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  SER 42  42  42  SER SER A . n 
A 1 43  GLN 43  43  43  GLN GLN A . n 
A 1 44  ARG 44  44  44  ARG ARG A . n 
A 1 45  MET 45  45  45  MET MET A . n 
A 1 46  GLU 46  46  46  GLU GLU A . n 
A 1 47  PRO 47  47  47  PRO PRO A . n 
A 1 48  ARG 48  48  48  ARG ARG A . n 
A 1 49  ALA 49  49  49  ALA ALA A . n 
A 1 50  PRO 50  50  50  PRO PRO A . n 
A 1 51  TRP 51  51  51  TRP TRP A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  GLU 53  53  53  GLU GLU A . n 
A 1 54  GLN 54  54  54  GLN GLN A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  GLY 56  56  56  GLY GLY A . n 
A 1 57  PRO 57  57  57  PRO PRO A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  TYR 59  59  59  TYR TYR A . n 
A 1 60  TRP 60  60  60  TRP TRP A . n 
A 1 61  ASP 61  61  61  ASP ASP A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  GLU 63  63  63  GLU GLU A . n 
A 1 64  THR 64  64  64  THR THR A . n 
A 1 65  GLY 65  65  65  GLY GLY A . n 
A 1 66  LYS 66  66  66  LYS LYS A . n 
A 1 67  VAL 67  67  67  VAL VAL A . n 
A 1 68  LYS 68  68  68  LYS LYS A . n 
A 1 69  ALA 69  69  69  ALA ALA A . n 
A 1 70  HIS 70  70  70  HIS HIS A . n 
A 1 71  SER 71  71  71  SER SER A . n 
A 1 72  GLN 72  72  72  GLN GLN A . n 
A 1 73  THR 73  73  73  THR THR A . n 
A 1 74  ASP 74  74  74  ASP ASP A . n 
A 1 75  ARG 75  75  75  ARG ARG A . n 
A 1 76  GLU 76  76  76  GLU GLU A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  ARG 79  79  79  ARG ARG A . n 
A 1 80  ILE 80  80  80  ILE ILE A . n 
A 1 81  ALA 81  81  81  ALA ALA A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  TYR 84  84  84  TYR TYR A . n 
A 1 85  TYR 85  85  85  TYR TYR A . n 
A 1 86  ASN 86  86  86  ASN ASN A . n 
A 1 87  GLN 87  87  87  GLN GLN A . n 
A 1 88  SER 88  88  88  SER SER A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  ALA 90  90  90  ALA ALA A . n 
A 1 91  GLY 91  91  91  GLY GLY A . n 
A 1 92  SER 92  92  92  SER SER A . n 
A 1 93  HIS 93  93  93  HIS HIS A . n 
A 1 94  THR 94  94  94  THR THR A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  GLN 96  96  96  GLN GLN A . n 
A 1 97  MET 97  97  97  MET MET A . n 
A 1 98  MET 98  98  98  MET MET A . n 
A 1 99  PHE 99  99  99  PHE PHE A . n 
A 1 100 GLY 100 100 100 GLY GLY A . n 
A 1 101 CYS 101 101 101 CYS CYS A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 GLY 104 104 104 GLY GLY A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 ASP 106 106 106 ASP ASP A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 ARG 108 108 108 ARG ARG A . n 
A 1 109 PHE 109 109 109 PHE PHE A . n 
A 1 110 LEU 110 110 110 LEU LEU A . n 
A 1 111 ARG 111 111 111 ARG ARG A . n 
A 1 112 GLY 112 112 112 GLY GLY A . n 
A 1 113 TYR 113 113 113 TYR TYR A . n 
A 1 114 HIS 114 114 114 HIS HIS A . n 
A 1 115 GLN 115 115 115 GLN GLN A . n 
A 1 116 TYR 116 116 116 TYR TYR A . n 
A 1 117 ALA 117 117 117 ALA ALA A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASP 119 119 119 ASP ASP A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 ASP 122 122 122 ASP ASP A . n 
A 1 123 TYR 123 123 123 TYR TYR A . n 
A 1 124 ILE 124 124 124 ILE ILE A . n 
A 1 125 ALA 125 125 125 ALA ALA A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 LYS 127 127 127 LYS LYS A . n 
A 1 128 GLU 128 128 128 GLU GLU A . n 
A 1 129 ASP 129 129 129 ASP ASP A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 SER 132 132 132 SER SER A . n 
A 1 133 TRP 133 133 133 TRP TRP A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 ALA 135 135 135 ALA ALA A . n 
A 1 136 ALA 136 136 136 ALA ALA A . n 
A 1 137 ASP 137 137 137 ASP ASP A . n 
A 1 138 MET 138 138 138 MET MET A . n 
A 1 139 ALA 139 139 139 ALA ALA A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 GLN 141 141 141 GLN GLN A . n 
A 1 142 ILE 142 142 142 ILE ILE A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 LYS 144 144 144 LYS LYS A . n 
A 1 145 ARG 145 145 145 ARG ARG A . n 
A 1 146 LYS 146 146 146 LYS LYS A . n 
A 1 147 TRP 147 147 147 TRP TRP A . n 
A 1 148 GLU 148 148 148 GLU GLU A . n 
A 1 149 ALA 149 149 149 ALA ALA A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 HIS 151 151 151 HIS HIS A . n 
A 1 152 VAL 152 152 152 VAL VAL A . n 
A 1 153 ALA 153 153 153 ALA ALA A . n 
A 1 154 GLU 154 154 154 GLU GLU A . n 
A 1 155 GLN 155 155 155 GLN GLN A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 ARG 157 157 157 ARG ARG A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 LEU 160 160 160 LEU LEU A . n 
A 1 161 GLU 161 161 161 GLU GLU A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 THR 163 163 163 THR THR A . n 
A 1 164 CYS 164 164 164 CYS CYS A . n 
A 1 165 VAL 165 165 165 VAL VAL A . n 
A 1 166 ASP 166 166 166 ASP ASP A . n 
A 1 167 GLY 167 167 167 GLY GLY A . n 
A 1 168 LEU 168 168 168 LEU LEU A . n 
A 1 169 ARG 169 169 169 ARG ARG A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 TYR 171 171 171 TYR TYR A . n 
A 1 172 LEU 172 172 172 LEU LEU A . n 
A 1 173 GLU 173 173 173 GLU GLU A . n 
A 1 174 ASN 174 174 174 ASN ASN A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 LYS 176 176 176 LYS LYS A . n 
A 1 177 GLU 177 177 177 GLU GLU A . n 
A 1 178 THR 178 178 178 THR THR A . n 
A 1 179 LEU 179 179 179 LEU LEU A . n 
A 1 180 GLN 180 180 180 GLN GLN A . n 
A 1 181 ARG 181 181 181 ARG ARG A . n 
A 1 182 THR 182 182 182 THR THR A . n 
A 1 183 ASP 183 183 183 ASP ASP A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PRO 185 185 185 PRO PRO A . n 
A 1 186 LYS 186 186 186 LYS LYS A . n 
A 1 187 THR 187 187 187 THR THR A . n 
A 1 188 HIS 188 188 188 HIS HIS A . n 
A 1 189 MET 189 189 189 MET MET A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 HIS 191 191 191 HIS HIS A . n 
A 1 192 HIS 192 192 192 HIS HIS A . n 
A 1 193 PRO 193 193 193 PRO PRO A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 ASP 196 196 196 ASP ASP A . n 
A 1 197 HIS 197 197 197 HIS HIS A . n 
A 1 198 GLU 198 198 198 GLU GLU A . n 
A 1 199 ALA 199 199 199 ALA ALA A . n 
A 1 200 THR 200 200 200 THR THR A . n 
A 1 201 LEU 201 201 201 LEU LEU A . n 
A 1 202 ARG 202 202 202 ARG ARG A . n 
A 1 203 CYS 203 203 203 CYS CYS A . n 
A 1 204 TRP 204 204 204 TRP TRP A . n 
A 1 205 ALA 205 205 205 ALA ALA A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 GLY 207 207 207 GLY GLY A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 PRO 210 210 210 PRO PRO A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 GLU 212 212 212 GLU GLU A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 THR 214 214 214 THR THR A . n 
A 1 215 LEU 215 215 215 LEU LEU A . n 
A 1 216 THR 216 216 216 THR THR A . n 
A 1 217 TRP 217 217 217 TRP TRP A . n 
A 1 218 GLN 218 218 218 GLN GLN A . n 
A 1 219 ARG 219 219 219 ARG ARG A . n 
A 1 220 ASP 220 220 220 ASP ASP A . n 
A 1 221 GLY 221 221 221 GLY GLY A . n 
A 1 222 GLU 222 222 222 GLU GLU A . n 
A 1 223 ASP 223 223 223 ASP ASP A . n 
A 1 224 GLN 224 224 224 GLN GLN A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 GLN 226 226 226 GLN GLN A . n 
A 1 227 ASP 227 227 227 ASP ASP A . n 
A 1 228 THR 228 228 228 THR THR A . n 
A 1 229 GLU 229 229 229 GLU GLU A . n 
A 1 230 LEU 230 230 230 LEU LEU A . n 
A 1 231 VAL 231 231 231 VAL VAL A . n 
A 1 232 GLU 232 232 232 GLU GLU A . n 
A 1 233 THR 233 233 233 THR THR A . n 
A 1 234 ARG 234 234 234 ARG ARG A . n 
A 1 235 PRO 235 235 235 PRO PRO A . n 
A 1 236 ALA 236 236 236 ALA ALA A . n 
A 1 237 GLY 237 237 237 GLY GLY A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 GLY 239 239 239 GLY GLY A . n 
A 1 240 THR 240 240 240 THR THR A . n 
A 1 241 PHE 241 241 241 PHE PHE A . n 
A 1 242 GLN 242 242 242 GLN GLN A . n 
A 1 243 LYS 243 243 243 LYS LYS A . n 
A 1 244 TRP 244 244 244 TRP TRP A . n 
A 1 245 ALA 245 245 245 ALA ALA A . n 
A 1 246 ALA 246 246 246 ALA ALA A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 VAL 248 248 248 VAL VAL A . n 
A 1 249 VAL 249 249 249 VAL VAL A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 SER 251 251 251 SER SER A . n 
A 1 252 GLY 252 252 252 GLY GLY A . n 
A 1 253 GLU 253 253 253 GLU GLU A . n 
A 1 254 GLU 254 254 254 GLU GLU A . n 
A 1 255 GLN 255 255 255 GLN GLN A . n 
A 1 256 ARG 256 256 256 ARG ARG A . n 
A 1 257 TYR 257 257 257 TYR TYR A . n 
A 1 258 THR 258 258 258 THR THR A . n 
A 1 259 CYS 259 259 259 CYS CYS A . n 
A 1 260 HIS 260 260 260 HIS HIS A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 GLN 262 262 262 GLN GLN A . n 
A 1 263 HIS 263 263 263 HIS HIS A . n 
A 1 264 GLU 264 264 264 GLU GLU A . n 
A 1 265 GLY 265 265 265 GLY GLY A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 PRO 267 267 267 PRO PRO A . n 
A 1 268 LYS 268 268 268 LYS LYS A . n 
A 1 269 PRO 269 269 269 PRO PRO A . n 
A 1 270 LEU 270 270 270 LEU LEU A . n 
A 1 271 THR 271 271 271 THR THR A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 ARG 273 273 273 ARG ARG A . n 
A 1 274 TRP 274 274 274 TRP TRP A . n 
B 2 1   ILE 1   1   1   ILE ILE B . n 
B 2 2   GLN 2   2   2   GLN GLN B . n 
B 2 3   ARG 3   3   3   ARG ARG B . n 
B 2 4   THR 4   4   4   THR THR B . n 
B 2 5   PRO 5   5   5   PRO PRO B . n 
B 2 6   LYS 6   6   6   LYS LYS B . n 
B 2 7   ILE 7   7   7   ILE ILE B . n 
B 2 8   GLN 8   8   8   GLN GLN B . n 
B 2 9   VAL 9   9   9   VAL VAL B . n 
B 2 10  TYR 10  10  10  TYR TYR B . n 
B 2 11  SER 11  11  11  SER SER B . n 
B 2 12  ARG 12  12  12  ARG ARG B . n 
B 2 13  HIS 13  13  13  HIS HIS B . n 
B 2 14  PRO 14  14  14  PRO PRO B . n 
B 2 15  ALA 15  15  15  ALA ALA B . n 
B 2 16  GLU 16  16  16  GLU GLU B . n 
B 2 17  ASN 17  17  17  ASN ASN B . n 
B 2 18  GLY 18  18  18  GLY GLY B . n 
B 2 19  LYS 19  19  19  LYS LYS B . n 
B 2 20  SER 20  20  20  SER SER B . n 
B 2 21  ASN 21  21  21  ASN ASN B . n 
B 2 22  PHE 22  22  22  PHE PHE B . n 
B 2 23  LEU 23  23  23  LEU LEU B . n 
B 2 24  ASN 24  24  24  ASN ASN B . n 
B 2 25  CYS 25  25  25  CYS CYS B . n 
B 2 26  TYR 26  26  26  TYR TYR B . n 
B 2 27  VAL 27  27  27  VAL VAL B . n 
B 2 28  SER 28  28  28  SER SER B . n 
B 2 29  GLY 29  29  29  GLY GLY B . n 
B 2 30  PHE 30  30  30  PHE PHE B . n 
B 2 31  HIS 31  31  31  HIS HIS B . n 
B 2 32  PRO 32  32  32  PRO PRO B . n 
B 2 33  SER 33  33  33  SER SER B . n 
B 2 34  ASP 34  34  34  ASP ASP B . n 
B 2 35  ILE 35  35  35  ILE ILE B . n 
B 2 36  GLU 36  36  36  GLU GLU B . n 
B 2 37  VAL 37  37  37  VAL VAL B . n 
B 2 38  ASP 38  38  38  ASP ASP B . n 
B 2 39  LEU 39  39  39  LEU LEU B . n 
B 2 40  LEU 40  40  40  LEU LEU B . n 
B 2 41  LYS 41  41  41  LYS LYS B . n 
B 2 42  ASN 42  42  42  ASN ASN B . n 
B 2 43  GLY 43  43  43  GLY GLY B . n 
B 2 44  GLU 44  44  44  GLU GLU B . n 
B 2 45  ARG 45  45  45  ARG ARG B . n 
B 2 46  ILE 46  46  46  ILE ILE B . n 
B 2 47  GLU 47  47  47  GLU GLU B . n 
B 2 48  LYS 48  48  48  LYS LYS B . n 
B 2 49  VAL 49  49  49  VAL VAL B . n 
B 2 50  GLU 50  50  50  GLU GLU B . n 
B 2 51  HIS 51  51  51  HIS HIS B . n 
B 2 52  SER 52  52  52  SER SER B . n 
B 2 53  ASP 53  53  53  ASP ASP B . n 
B 2 54  LEU 54  54  54  LEU LEU B . n 
B 2 55  SER 55  55  55  SER SER B . n 
B 2 56  PHE 56  56  56  PHE PHE B . n 
B 2 57  SER 57  57  57  SER SER B . n 
B 2 58  LYS 58  58  58  LYS LYS B . n 
B 2 59  ASP 59  59  59  ASP ASP B . n 
B 2 60  TRP 60  60  60  TRP TRP B . n 
B 2 61  SER 61  61  61  SER SER B . n 
B 2 62  PHE 62  62  62  PHE PHE B . n 
B 2 63  TYR 63  63  63  TYR TYR B . n 
B 2 64  LEU 64  64  64  LEU LEU B . n 
B 2 65  LEU 65  65  65  LEU LEU B . n 
B 2 66  TYR 66  66  66  TYR TYR B . n 
B 2 67  TYR 67  67  67  TYR TYR B . n 
B 2 68  THR 68  68  68  THR THR B . n 
B 2 69  GLU 69  69  69  GLU GLU B . n 
B 2 70  PHE 70  70  70  PHE PHE B . n 
B 2 71  THR 71  71  71  THR THR B . n 
B 2 72  PRO 72  72  72  PRO PRO B . n 
B 2 73  THR 73  73  73  THR THR B . n 
B 2 74  GLU 74  74  74  GLU GLU B . n 
B 2 75  LYS 75  75  75  LYS LYS B . n 
B 2 76  ASP 76  76  76  ASP ASP B . n 
B 2 77  GLU 77  77  77  GLU GLU B . n 
B 2 78  TYR 78  78  78  TYR TYR B . n 
B 2 79  ALA 79  79  79  ALA ALA B . n 
B 2 80  CYS 80  80  80  CYS CYS B . n 
B 2 81  ARG 81  81  81  ARG ARG B . n 
B 2 82  VAL 82  82  82  VAL VAL B . n 
B 2 83  ASN 83  83  83  ASN ASN B . n 
B 2 84  HIS 84  84  84  HIS HIS B . n 
B 2 85  VAL 85  85  85  VAL VAL B . n 
B 2 86  THR 86  86  86  THR THR B . n 
B 2 87  LEU 87  87  87  LEU LEU B . n 
B 2 88  SER 88  88  88  SER SER B . n 
B 2 89  GLN 89  89  89  GLN GLN B . n 
B 2 90  PRO 90  90  90  PRO PRO B . n 
B 2 91  LYS 91  91  91  LYS LYS B . n 
B 2 92  ILE 92  92  92  ILE ILE B . n 
B 2 93  VAL 93  93  93  VAL VAL B . n 
B 2 94  LYS 94  94  94  LYS LYS B . n 
B 2 95  TRP 95  95  95  TRP TRP B . n 
B 2 96  ASP 96  96  96  ASP ASP B . n 
B 2 97  ARG 97  97  97  ARG ARG B . n 
B 2 98  ASP 98  98  98  ASP ASP B . n 
B 2 99  MET 99  99  99  MET MET B . n 
C 3 1   ASN 1   1   1   ASN ASN E . n 
C 3 2   TYR 2   2   2   TYR TYR E . n 
C 3 3   ASN 3   3   3   ASN ASN E . n 
C 3 4   TYR 4   4   4   TYR TYR E . n 
C 3 5   LEU 5   5   5   LEU LEU E . n 
C 3 6   TYR 6   6   6   TYR TYR E . n 
C 3 7   ARG 7   7   7   ARG ARG E . n 
C 3 8   LEU 8   8   8   LEU LEU E . n 
C 3 9   LEU 9   9   9   LEU LEU E . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 HOH 1   301 203 HOH HOH A . 
D 4 HOH 2   302 99  HOH HOH A . 
D 4 HOH 3   303 280 HOH HOH A . 
D 4 HOH 4   304 121 HOH HOH A . 
D 4 HOH 5   305 55  HOH HOH A . 
D 4 HOH 6   306 7   HOH HOH A . 
D 4 HOH 7   307 226 HOH HOH A . 
D 4 HOH 8   308 250 HOH HOH A . 
D 4 HOH 9   309 177 HOH HOH A . 
D 4 HOH 10  310 98  HOH HOH A . 
D 4 HOH 11  311 112 HOH HOH A . 
D 4 HOH 12  312 103 HOH HOH A . 
D 4 HOH 13  313 130 HOH HOH A . 
D 4 HOH 14  314 86  HOH HOH A . 
D 4 HOH 15  315 182 HOH HOH A . 
D 4 HOH 16  316 1   HOH HOH A . 
D 4 HOH 17  317 277 HOH HOH A . 
D 4 HOH 18  318 102 HOH HOH A . 
D 4 HOH 19  319 90  HOH HOH A . 
D 4 HOH 20  320 8   HOH HOH A . 
D 4 HOH 21  321 71  HOH HOH A . 
D 4 HOH 22  322 73  HOH HOH A . 
D 4 HOH 23  323 111 HOH HOH A . 
D 4 HOH 24  324 37  HOH HOH A . 
D 4 HOH 25  325 15  HOH HOH A . 
D 4 HOH 26  326 14  HOH HOH A . 
D 4 HOH 27  327 137 HOH HOH A . 
D 4 HOH 28  328 10  HOH HOH A . 
D 4 HOH 29  329 82  HOH HOH A . 
D 4 HOH 30  330 40  HOH HOH A . 
D 4 HOH 31  331 169 HOH HOH A . 
D 4 HOH 32  332 45  HOH HOH A . 
D 4 HOH 33  333 233 HOH HOH A . 
D 4 HOH 34  334 6   HOH HOH A . 
D 4 HOH 35  335 202 HOH HOH A . 
D 4 HOH 36  336 108 HOH HOH A . 
D 4 HOH 37  337 262 HOH HOH A . 
D 4 HOH 38  338 101 HOH HOH A . 
D 4 HOH 39  339 105 HOH HOH A . 
D 4 HOH 40  340 207 HOH HOH A . 
D 4 HOH 41  341 51  HOH HOH A . 
D 4 HOH 42  342 285 HOH HOH A . 
D 4 HOH 43  343 243 HOH HOH A . 
D 4 HOH 44  344 96  HOH HOH A . 
D 4 HOH 45  345 106 HOH HOH A . 
D 4 HOH 46  346 161 HOH HOH A . 
D 4 HOH 47  347 22  HOH HOH A . 
D 4 HOH 48  348 118 HOH HOH A . 
D 4 HOH 49  349 186 HOH HOH A . 
D 4 HOH 50  350 66  HOH HOH A . 
D 4 HOH 51  351 245 HOH HOH A . 
D 4 HOH 52  352 18  HOH HOH A . 
D 4 HOH 53  353 78  HOH HOH A . 
D 4 HOH 54  354 3   HOH HOH A . 
D 4 HOH 55  355 56  HOH HOH A . 
D 4 HOH 56  356 29  HOH HOH A . 
D 4 HOH 57  357 61  HOH HOH A . 
D 4 HOH 58  358 43  HOH HOH A . 
D 4 HOH 59  359 119 HOH HOH A . 
D 4 HOH 60  360 13  HOH HOH A . 
D 4 HOH 61  361 229 HOH HOH A . 
D 4 HOH 62  362 75  HOH HOH A . 
D 4 HOH 63  363 205 HOH HOH A . 
D 4 HOH 64  364 12  HOH HOH A . 
D 4 HOH 65  365 36  HOH HOH A . 
D 4 HOH 66  366 166 HOH HOH A . 
D 4 HOH 67  367 30  HOH HOH A . 
D 4 HOH 68  368 147 HOH HOH A . 
D 4 HOH 69  369 155 HOH HOH A . 
D 4 HOH 70  370 27  HOH HOH A . 
D 4 HOH 71  371 143 HOH HOH A . 
D 4 HOH 72  372 35  HOH HOH A . 
D 4 HOH 73  373 141 HOH HOH A . 
D 4 HOH 74  374 5   HOH HOH A . 
D 4 HOH 75  375 50  HOH HOH A . 
D 4 HOH 76  376 198 HOH HOH A . 
D 4 HOH 77  377 264 HOH HOH A . 
D 4 HOH 78  378 67  HOH HOH A . 
D 4 HOH 79  379 282 HOH HOH A . 
D 4 HOH 80  380 65  HOH HOH A . 
D 4 HOH 81  381 197 HOH HOH A . 
D 4 HOH 82  382 184 HOH HOH A . 
D 4 HOH 83  383 24  HOH HOH A . 
D 4 HOH 84  384 19  HOH HOH A . 
D 4 HOH 85  385 80  HOH HOH A . 
D 4 HOH 86  386 159 HOH HOH A . 
D 4 HOH 87  387 9   HOH HOH A . 
D 4 HOH 88  388 23  HOH HOH A . 
D 4 HOH 89  389 171 HOH HOH A . 
D 4 HOH 90  390 95  HOH HOH A . 
D 4 HOH 91  391 109 HOH HOH A . 
D 4 HOH 92  392 227 HOH HOH A . 
D 4 HOH 93  393 152 HOH HOH A . 
D 4 HOH 94  394 139 HOH HOH A . 
D 4 HOH 95  395 97  HOH HOH A . 
D 4 HOH 96  396 181 HOH HOH A . 
D 4 HOH 97  397 62  HOH HOH A . 
D 4 HOH 98  398 276 HOH HOH A . 
D 4 HOH 99  399 237 HOH HOH A . 
D 4 HOH 100 400 77  HOH HOH A . 
D 4 HOH 101 401 153 HOH HOH A . 
D 4 HOH 102 402 115 HOH HOH A . 
D 4 HOH 103 403 204 HOH HOH A . 
D 4 HOH 104 404 64  HOH HOH A . 
D 4 HOH 105 405 193 HOH HOH A . 
D 4 HOH 106 406 33  HOH HOH A . 
D 4 HOH 107 407 16  HOH HOH A . 
D 4 HOH 108 408 259 HOH HOH A . 
D 4 HOH 109 409 211 HOH HOH A . 
D 4 HOH 110 410 120 HOH HOH A . 
D 4 HOH 111 411 59  HOH HOH A . 
D 4 HOH 112 412 239 HOH HOH A . 
D 4 HOH 113 413 87  HOH HOH A . 
D 4 HOH 114 414 270 HOH HOH A . 
D 4 HOH 115 415 144 HOH HOH A . 
D 4 HOH 116 416 212 HOH HOH A . 
D 4 HOH 117 417 224 HOH HOH A . 
D 4 HOH 118 418 26  HOH HOH A . 
D 4 HOH 119 419 196 HOH HOH A . 
D 4 HOH 120 420 110 HOH HOH A . 
D 4 HOH 121 421 174 HOH HOH A . 
D 4 HOH 122 422 134 HOH HOH A . 
D 4 HOH 123 423 49  HOH HOH A . 
D 4 HOH 124 424 124 HOH HOH A . 
D 4 HOH 125 425 39  HOH HOH A . 
D 4 HOH 126 426 160 HOH HOH A . 
D 4 HOH 127 427 210 HOH HOH A . 
D 4 HOH 128 428 127 HOH HOH A . 
D 4 HOH 129 429 236 HOH HOH A . 
D 4 HOH 130 430 84  HOH HOH A . 
D 4 HOH 131 431 286 HOH HOH A . 
D 4 HOH 132 432 122 HOH HOH A . 
D 4 HOH 133 433 176 HOH HOH A . 
D 4 HOH 134 434 216 HOH HOH A . 
D 4 HOH 135 435 114 HOH HOH A . 
D 4 HOH 136 436 241 HOH HOH A . 
D 4 HOH 137 437 255 HOH HOH A . 
D 4 HOH 138 438 248 HOH HOH A . 
D 4 HOH 139 439 208 HOH HOH A . 
D 4 HOH 140 440 172 HOH HOH A . 
D 4 HOH 141 441 263 HOH HOH A . 
D 4 HOH 142 442 89  HOH HOH A . 
D 4 HOH 143 443 173 HOH HOH A . 
D 4 HOH 144 444 206 HOH HOH A . 
D 4 HOH 145 445 222 HOH HOH A . 
D 4 HOH 146 446 231 HOH HOH A . 
D 4 HOH 147 447 214 HOH HOH A . 
D 4 HOH 148 448 268 HOH HOH A . 
D 4 HOH 149 449 140 HOH HOH A . 
D 4 HOH 150 450 251 HOH HOH A . 
D 4 HOH 151 451 200 HOH HOH A . 
D 4 HOH 152 452 52  HOH HOH A . 
D 4 HOH 153 453 74  HOH HOH A . 
D 4 HOH 154 454 240 HOH HOH A . 
D 4 HOH 155 455 28  HOH HOH A . 
D 4 HOH 156 456 123 HOH HOH A . 
D 4 HOH 157 457 244 HOH HOH A . 
D 4 HOH 158 458 271 HOH HOH A . 
D 4 HOH 159 459 238 HOH HOH A . 
D 4 HOH 160 460 136 HOH HOH A . 
D 4 HOH 161 461 165 HOH HOH A . 
D 4 HOH 162 462 188 HOH HOH A . 
D 4 HOH 163 463 252 HOH HOH A . 
D 4 HOH 164 464 278 HOH HOH A . 
D 4 HOH 165 465 261 HOH HOH A . 
D 4 HOH 166 466 113 HOH HOH A . 
D 4 HOH 167 467 76  HOH HOH A . 
D 4 HOH 168 468 132 HOH HOH A . 
D 4 HOH 169 469 116 HOH HOH A . 
D 4 HOH 170 470 213 HOH HOH A . 
D 4 HOH 171 471 189 HOH HOH A . 
D 4 HOH 172 472 187 HOH HOH A . 
D 4 HOH 173 473 267 HOH HOH A . 
D 4 HOH 174 474 256 HOH HOH A . 
D 4 HOH 175 475 273 HOH HOH A . 
E 4 HOH 1   101 218 HOH HOH B . 
E 4 HOH 2   102 190 HOH HOH B . 
E 4 HOH 3   103 85  HOH HOH B . 
E 4 HOH 4   104 81  HOH HOH B . 
E 4 HOH 5   105 47  HOH HOH B . 
E 4 HOH 6   106 48  HOH HOH B . 
E 4 HOH 7   107 54  HOH HOH B . 
E 4 HOH 8   108 69  HOH HOH B . 
E 4 HOH 9   109 83  HOH HOH B . 
E 4 HOH 10  110 38  HOH HOH B . 
E 4 HOH 11  111 129 HOH HOH B . 
E 4 HOH 12  112 279 HOH HOH B . 
E 4 HOH 13  113 41  HOH HOH B . 
E 4 HOH 14  114 2   HOH HOH B . 
E 4 HOH 15  115 223 HOH HOH B . 
E 4 HOH 16  116 131 HOH HOH B . 
E 4 HOH 17  117 34  HOH HOH B . 
E 4 HOH 18  118 21  HOH HOH B . 
E 4 HOH 19  119 72  HOH HOH B . 
E 4 HOH 20  120 46  HOH HOH B . 
E 4 HOH 21  121 20  HOH HOH B . 
E 4 HOH 22  122 253 HOH HOH B . 
E 4 HOH 23  123 79  HOH HOH B . 
E 4 HOH 24  124 11  HOH HOH B . 
E 4 HOH 25  125 57  HOH HOH B . 
E 4 HOH 26  126 269 HOH HOH B . 
E 4 HOH 27  127 178 HOH HOH B . 
E 4 HOH 28  128 258 HOH HOH B . 
E 4 HOH 29  129 163 HOH HOH B . 
E 4 HOH 30  130 225 HOH HOH B . 
E 4 HOH 31  131 31  HOH HOH B . 
E 4 HOH 32  132 17  HOH HOH B . 
E 4 HOH 33  133 138 HOH HOH B . 
E 4 HOH 34  134 272 HOH HOH B . 
E 4 HOH 35  135 183 HOH HOH B . 
E 4 HOH 36  136 219 HOH HOH B . 
E 4 HOH 37  137 228 HOH HOH B . 
E 4 HOH 38  138 4   HOH HOH B . 
E 4 HOH 39  139 125 HOH HOH B . 
E 4 HOH 40  140 25  HOH HOH B . 
E 4 HOH 41  141 185 HOH HOH B . 
E 4 HOH 42  142 215 HOH HOH B . 
E 4 HOH 43  143 149 HOH HOH B . 
E 4 HOH 44  144 53  HOH HOH B . 
E 4 HOH 45  145 151 HOH HOH B . 
E 4 HOH 46  146 195 HOH HOH B . 
E 4 HOH 47  147 283 HOH HOH B . 
E 4 HOH 48  148 170 HOH HOH B . 
E 4 HOH 49  149 249 HOH HOH B . 
E 4 HOH 50  150 70  HOH HOH B . 
E 4 HOH 51  151 168 HOH HOH B . 
E 4 HOH 52  152 235 HOH HOH B . 
E 4 HOH 53  153 156 HOH HOH B . 
E 4 HOH 54  154 217 HOH HOH B . 
E 4 HOH 55  155 135 HOH HOH B . 
E 4 HOH 56  156 100 HOH HOH B . 
E 4 HOH 57  157 164 HOH HOH B . 
E 4 HOH 58  158 265 HOH HOH B . 
E 4 HOH 59  159 133 HOH HOH B . 
E 4 HOH 60  160 142 HOH HOH B . 
E 4 HOH 61  161 117 HOH HOH B . 
E 4 HOH 62  162 150 HOH HOH B . 
E 4 HOH 63  163 254 HOH HOH B . 
E 4 HOH 64  164 92  HOH HOH B . 
E 4 HOH 65  165 126 HOH HOH B . 
E 4 HOH 66  166 158 HOH HOH B . 
E 4 HOH 67  167 167 HOH HOH B . 
E 4 HOH 68  168 104 HOH HOH B . 
E 4 HOH 69  169 63  HOH HOH B . 
E 4 HOH 70  170 146 HOH HOH B . 
E 4 HOH 71  171 128 HOH HOH B . 
E 4 HOH 72  172 257 HOH HOH B . 
E 4 HOH 73  173 220 HOH HOH B . 
E 4 HOH 74  174 275 HOH HOH B . 
E 4 HOH 75  175 201 HOH HOH B . 
E 4 HOH 76  176 154 HOH HOH B . 
E 4 HOH 77  177 209 HOH HOH B . 
E 4 HOH 78  178 107 HOH HOH B . 
E 4 HOH 79  179 274 HOH HOH B . 
E 4 HOH 80  180 148 HOH HOH B . 
E 4 HOH 81  181 230 HOH HOH B . 
E 4 HOH 82  182 221 HOH HOH B . 
E 4 HOH 83  183 232 HOH HOH B . 
E 4 HOH 84  184 191 HOH HOH B . 
E 4 HOH 85  185 284 HOH HOH B . 
E 4 HOH 86  186 246 HOH HOH B . 
E 4 HOH 87  187 162 HOH HOH B . 
E 4 HOH 88  188 260 HOH HOH B . 
E 4 HOH 89  189 234 HOH HOH B . 
E 4 HOH 90  190 175 HOH HOH B . 
E 4 HOH 91  191 58  HOH HOH B . 
E 4 HOH 92  192 180 HOH HOH B . 
E 4 HOH 93  193 194 HOH HOH B . 
E 4 HOH 94  194 281 HOH HOH B . 
E 4 HOH 95  195 199 HOH HOH B . 
E 4 HOH 96  196 179 HOH HOH B . 
E 4 HOH 97  197 145 HOH HOH B . 
E 4 HOH 98  198 242 HOH HOH B . 
E 4 HOH 99  199 266 HOH HOH B . 
F 4 HOH 1   101 91  HOH HOH E . 
F 4 HOH 2   102 44  HOH HOH E . 
F 4 HOH 3   103 60  HOH HOH E . 
F 4 HOH 4   104 192 HOH HOH E . 
F 4 HOH 5   105 32  HOH HOH E . 
F 4 HOH 6   106 93  HOH HOH E . 
F 4 HOH 7   107 68  HOH HOH E . 
F 4 HOH 8   108 88  HOH HOH E . 
F 4 HOH 9   109 94  HOH HOH E . 
F 4 HOH 10  110 42  HOH HOH E . 
F 4 HOH 11  111 247 HOH HOH E . 
F 4 HOH 12  112 157 HOH HOH E . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.13_2998 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.13_2998 2 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .         3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.420 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YZR 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     162.672 
_cell.length_a_esd                 ? 
_cell.length_b                     65.388 
_cell.length_b_esd                 ? 
_cell.length_c                     50.311 
_cell.length_c_esd                 ? 
_cell.volume                       535133.503 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YZR 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YZR 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.00 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          59.06 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M MES monohydrate pH 6.0, 20% (w/v) Polyethylene glycol 2,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-03-14 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL02U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL02U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          19.69 
_reflns.entry_id                                       8YZR 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.76 
_reflns.d_resolution_low                               60.67 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     41724 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           84.90 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.600 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.094 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.799 
_reflns_shell.d_res_low                                     1.863 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             41724 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.094 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.76 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YZR 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.80 
_refine.ls_d_res_low                             50.31 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     41724 
_refine.ls_number_reflns_R_free                  1999 
_refine.ls_number_reflns_R_work                  39725 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    84.90 
_refine.ls_percent_reflns_R_free                 4.79 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2256 
_refine.ls_R_factor_R_free                       0.2615 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2237 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      7f4w 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 33.7638 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3243 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.80 
_refine_hist.d_res_low                        50.31 
_refine_hist.number_atoms_solvent             286 
_refine_hist.number_atoms_total               3424 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3138 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0083 ? 3223 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0388 ? 4368 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0626 ? 443  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0146 ? 575  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.6764 ? 432  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.80 1.84  . . 153 2927 88.74  . . . . 0.3332 . . . . . . . . . . . 0.4128 
'X-RAY DIFFRACTION' 1.84 1.89  . . 109 1828 55.97  . . . . 0.3909 . . . . . . . . . . . 0.4272 
'X-RAY DIFFRACTION' 1.89 1.95  . . 60  1319 39.24  . . . . 0.6130 . . . . . . . . . . . 0.6749 
'X-RAY DIFFRACTION' 1.95 2.01  . . 157 3303 98.66  . . . . 0.2959 . . . . . . . . . . . 0.3280 
'X-RAY DIFFRACTION' 2.01 2.08  . . 107 2337 70.25  . . . . 0.3634 . . . . . . . . . . . 0.4199 
'X-RAY DIFFRACTION' 2.08 2.17  . . 140 2901 86.89  . . . . 0.2566 . . . . . . . . . . . 0.2948 
'X-RAY DIFFRACTION' 2.17 2.27  . . 120 2754 82.49  . . . . 0.3076 . . . . . . . . . . . 0.4242 
'X-RAY DIFFRACTION' 2.27 2.39  . . 144 2990 89.54  . . . . 0.2332 . . . . . . . . . . . 0.3134 
'X-RAY DIFFRACTION' 2.39 2.53  . . 173 3359 100.00 . . . . 0.2197 . . . . . . . . . . . 0.2599 
'X-RAY DIFFRACTION' 2.54 2.73  . . 135 3055 91.01  . . . . 0.2356 . . . . . . . . . . . 0.2872 
'X-RAY DIFFRACTION' 2.73 3.01  . . 157 3331 99.97  . . . . 0.2186 . . . . . . . . . . . 0.2880 
'X-RAY DIFFRACTION' 3.01 3.42  . . 192 3201 99.53  . . . . 0.1910 . . . . . . . . . . . 0.2259 
'X-RAY DIFFRACTION' 3.45 4.33  . . 173 2987 90.29  . . . . 0.1589 . . . . . . . . . . . 0.1873 
'X-RAY DIFFRACTION' 4.33 50.31 . . 179 3433 99.83  . . . . 0.1657 . . . . . . . . . . . 0.1916 
# 
_struct.entry_id                     8YZR 
_struct.title                        'The structure of HLA-A*2402 complex with peptide from SARS-CoV-2 S448-456 NYNYLYRLL(EG.5.1)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YZR 
_struct_keywords.text            'Complex, Peptide presentation, Immune system' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
F N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP A0A143Y4R2_HUMAN A0A143Y4R2 ? 1 
;GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDEETGKVKAHSQTDRENLRI
ALRYYNQSEAGSHTLQMMFGCDVGSDGRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQITKRKWEAAHVAEQQRAYL
EGTCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRW
;
25  
2 UNP B2MG_HUMAN       P61769     ? 2 
;IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYAC
RVNHVTLSQPKIVKWDRDM
;
21  
3 UNP SPIKE_SARS2      P0DTC2     ? 3 NYNYLYRLF 448 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YZR A 1 ? 274 ? A0A143Y4R2 25  ? 298 ? 1 274 
2 2 8YZR B 1 ? 99  ? P61769     21  ? 119 ? 1 99  
3 3 8YZR E 1 ? 9   ? P0DTC2     448 ? 456 ? 1 9   
# 
_struct_ref_seq_dif.align_id                     3 
_struct_ref_seq_dif.pdbx_pdb_id_code             8YZR 
_struct_ref_seq_dif.mon_id                       LEU 
_struct_ref_seq_dif.pdbx_pdb_strand_id           E 
_struct_ref_seq_dif.seq_num                      9 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTC2 
_struct_ref_seq_dif.db_mon_id                    PHE 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          456 
_struct_ref_seq_dif.details                      variant 
_struct_ref_seq_dif.pdbx_auth_seq_num            9 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4410  ? 
1 MORE         -17   ? 
1 'SSA (A^2)'  18840 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ALA A 49  ? GLU A 53  ? ALA A 49  GLU A 53  5 ? 5  
HELX_P HELX_P2 AA2 GLY A 56  ? ASN A 86  ? GLY A 56  ASN A 86  1 ? 31 
HELX_P HELX_P3 AA3 ASP A 137 ? HIS A 151 ? ASP A 137 HIS A 151 1 ? 15 
HELX_P HELX_P4 AA4 HIS A 151 ? GLY A 162 ? HIS A 151 GLY A 162 1 ? 12 
HELX_P HELX_P5 AA5 GLY A 162 ? GLY A 175 ? GLY A 162 GLY A 175 1 ? 14 
HELX_P HELX_P6 AA6 GLY A 175 ? GLN A 180 ? GLY A 175 GLN A 180 1 ? 6  
HELX_P HELX_P7 AA7 GLU A 253 ? GLN A 255 ? GLU A 253 GLN A 255 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 101 SG ? ? ? 1_555 A CYS 164 SG ? ? A CYS 101 A CYS 164 1_555 ? ? ? ? ? ? ? 2.085 ? ? 
disulf2 disulf ? ? A CYS 203 SG ? ? ? 1_555 A CYS 259 SG ? ? A CYS 203 A CYS 259 1_555 ? ? ? ? ? ? ? 2.056 ? ? 
disulf3 disulf ? ? B CYS 25  SG ? ? ? 1_555 B CYS 80  SG ? ? B CYS 25  B CYS 80  1_555 ? ? ? ? ? ? ? 2.025 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 101 ? CYS A 164 ? CYS A 101 ? 1_555 CYS A 164 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 203 ? CYS A 259 ? CYS A 203 ? 1_555 CYS A 259 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS B 25  ? CYS B 80  ? CYS B 25  ? 1_555 CYS B 80  ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 TYR 209 A . ? TYR 209 A PRO 210 A ? PRO 210 A 1 -1.53 
2 HIS 31  B . ? HIS 31  B PRO 32  B ? PRO 32  B 1 0.40  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA1 7 8 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 46  ? PRO A 47  ? GLU A 46  PRO A 47  
AA1 2 THR A 31  ? ASP A 37  ? THR A 31  ASP A 37  
AA1 3 ARG A 21  ? VAL A 28  ? ARG A 21  VAL A 28  
AA1 4 HIS A 3   ? VAL A 12  ? HIS A 3   VAL A 12  
AA1 5 THR A 94  ? VAL A 103 ? THR A 94  VAL A 103 
AA1 6 PHE A 109 ? TYR A 118 ? PHE A 109 TYR A 118 
AA1 7 LYS A 121 ? LEU A 126 ? LYS A 121 LEU A 126 
AA1 8 TRP A 133 ? ALA A 135 ? TRP A 133 ALA A 135 
AA2 1 LYS A 186 ? PRO A 193 ? LYS A 186 PRO A 193 
AA2 2 GLU A 198 ? PHE A 208 ? GLU A 198 PHE A 208 
AA2 3 PHE A 241 ? PRO A 250 ? PHE A 241 PRO A 250 
AA2 4 THR A 228 ? LEU A 230 ? THR A 228 LEU A 230 
AA3 1 LYS A 186 ? PRO A 193 ? LYS A 186 PRO A 193 
AA3 2 GLU A 198 ? PHE A 208 ? GLU A 198 PHE A 208 
AA3 3 PHE A 241 ? PRO A 250 ? PHE A 241 PRO A 250 
AA3 4 ARG A 234 ? PRO A 235 ? ARG A 234 PRO A 235 
AA4 1 GLU A 222 ? ASP A 223 ? GLU A 222 ASP A 223 
AA4 2 THR A 214 ? ARG A 219 ? THR A 214 ARG A 219 
AA4 3 TYR A 257 ? GLN A 262 ? TYR A 257 GLN A 262 
AA4 4 LEU A 270 ? LEU A 272 ? LEU A 270 LEU A 272 
AA5 1 LYS B 6   ? SER B 11  ? LYS B 6   SER B 11  
AA5 2 ASN B 21  ? PHE B 30  ? ASN B 21  PHE B 30  
AA5 3 PHE B 62  ? PHE B 70  ? PHE B 62  PHE B 70  
AA5 4 GLU B 50  ? HIS B 51  ? GLU B 50  HIS B 51  
AA6 1 LYS B 6   ? SER B 11  ? LYS B 6   SER B 11  
AA6 2 ASN B 21  ? PHE B 30  ? ASN B 21  PHE B 30  
AA6 3 PHE B 62  ? PHE B 70  ? PHE B 62  PHE B 70  
AA6 4 SER B 55  ? PHE B 56  ? SER B 55  PHE B 56  
AA7 1 GLU B 44  ? ARG B 45  ? GLU B 44  ARG B 45  
AA7 2 GLU B 36  ? LYS B 41  ? GLU B 36  LYS B 41  
AA7 3 TYR B 78  ? ASN B 83  ? TYR B 78  ASN B 83  
AA7 4 LYS B 91  ? LYS B 94  ? LYS B 91  LYS B 94  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLU A 46  ? O GLU A 46  N ARG A 35  ? N ARG A 35  
AA1 2 3 O PHE A 33  ? O PHE A 33  N GLY A 26  ? N GLY A 26  
AA1 3 4 O ILE A 23  ? O ILE A 23  N THR A 10  ? N THR A 10  
AA1 4 5 N SER A 11  ? N SER A 11  O LEU A 95  ? O LEU A 95  
AA1 5 6 N ASP A 102 ? N ASP A 102 O LEU A 110 ? O LEU A 110 
AA1 6 7 N TYR A 116 ? N TYR A 116 O ILE A 124 ? O ILE A 124 
AA1 7 8 N ALA A 125 ? N ALA A 125 O THR A 134 ? O THR A 134 
AA2 1 2 N HIS A 192 ? N HIS A 192 O THR A 200 ? O THR A 200 
AA2 2 3 N CYS A 203 ? N CYS A 203 O ALA A 245 ? O ALA A 245 
AA2 3 4 O ALA A 246 ? O ALA A 246 N GLU A 229 ? N GLU A 229 
AA3 1 2 N HIS A 192 ? N HIS A 192 O THR A 200 ? O THR A 200 
AA3 2 3 N CYS A 203 ? N CYS A 203 O ALA A 245 ? O ALA A 245 
AA3 3 4 O GLN A 242 ? O GLN A 242 N ARG A 234 ? N ARG A 234 
AA4 1 2 O GLU A 222 ? O GLU A 222 N ARG A 219 ? N ARG A 219 
AA4 2 3 N THR A 216 ? N THR A 216 O HIS A 260 ? O HIS A 260 
AA4 3 4 N CYS A 259 ? N CYS A 259 O LEU A 272 ? O LEU A 272 
AA5 1 2 N TYR B 10  ? N TYR B 10  O ASN B 24  ? O ASN B 24  
AA5 2 3 N LEU B 23  ? N LEU B 23  O THR B 68  ? O THR B 68  
AA5 3 4 O TYR B 67  ? O TYR B 67  N GLU B 50  ? N GLU B 50  
AA6 1 2 N TYR B 10  ? N TYR B 10  O ASN B 24  ? O ASN B 24  
AA6 2 3 N LEU B 23  ? N LEU B 23  O THR B 68  ? O THR B 68  
AA6 3 4 O TYR B 63  ? O TYR B 63  N SER B 55  ? N SER B 55  
AA7 1 2 O GLU B 44  ? O GLU B 44  N LYS B 41  ? N LYS B 41  
AA7 2 3 N ASP B 38  ? N ASP B 38  O ARG B 81  ? O ARG B 81  
AA7 3 4 N VAL B 82  ? N VAL B 82  O LYS B 91  ? O LYS B 91  
# 
_pdbx_entry_details.entry_id                   8YZR 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   A HOH 396 ? ? O A HOH 444 ? ? 2.11 
2  1 O   B HOH 154 ? ? O B HOH 190 ? ? 2.11 
3  1 ND1 B HIS 31  ? ? O B HOH 101 ? ? 2.13 
4  1 O   B HOH 120 ? ? O B HOH 193 ? ? 2.14 
5  1 NH1 A ARG 131 ? ? O A HOH 301 ? ? 2.16 
6  1 O   A HOH 466 ? ? O B HOH 193 ? ? 2.16 
7  1 O   A HOH 307 ? ? O A HOH 441 ? ? 2.16 
8  1 O   A HOH 399 ? ? O A HOH 438 ? ? 2.16 
9  1 O   B HOH 171 ? ? O B HOH 180 ? ? 2.17 
10 1 O   A HOH 327 ? ? O A HOH 440 ? ? 2.18 
11 1 O   A HOH 308 ? ? O A HOH 439 ? ? 2.18 
12 1 NE2 A GLN 255 ? ? O A HOH 302 ? ? 2.18 
13 1 O   B HOH 137 ? ? O B HOH 147 ? ? 2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 17  ? ? -141.31 30.09   
2 1 ASP A 29  ? ? 51.35   -123.15 
3 1 ARG A 111 ? ? -170.82 148.78  
4 1 HIS A 114 ? ? -170.58 91.46   
5 1 ASP A 122 ? ? -38.54  132.50  
6 1 TYR A 123 ? ? -115.76 -73.08  
7 1 SER A 195 ? ? -163.98 -169.99 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     256 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.119 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     357 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   D 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7f4w 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YZR 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.006147 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000045 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015293 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019877 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLY A 1 1   ? -18.77933 -13.03318 24.90279  1.000 34.25718 ? 1   GLY A N   1 
ATOM   2    C CA  . GLY A 1 1   ? -17.34739 -12.80618 24.95130  1.000 26.89696 ? 1   GLY A CA  1 
ATOM   3    C C   . GLY A 1 1   ? -16.56194 -14.10365 24.84754  1.000 29.04154 ? 1   GLY A C   1 
ATOM   4    O O   . GLY A 1 1   ? -15.36609 -14.09384 24.54277  1.000 34.23222 ? 1   GLY A O   1 
ATOM   5    N N   . SER A 1 2   ? -17.23608 -15.22276 25.08743  1.000 27.62922 ? 2   SER A N   1 
ATOM   6    C CA  . SER A 1 2   ? -16.59045 -16.52498 25.05552  1.000 25.54335 ? 2   SER A CA  1 
ATOM   7    C C   . SER A 1 2   ? -16.64453 -17.13835 23.64867  1.000 23.43371 ? 2   SER A C   1 
ATOM   8    O O   . SER A 1 2   ? -17.43460 -16.73949 22.78519  1.000 20.08973 ? 2   SER A O   1 
ATOM   9    C CB  . SER A 1 2   ? -17.22468 -17.45290 26.09055  1.000 23.29831 ? 2   SER A CB  1 
ATOM   10   O OG  . SER A 1 2   ? -18.40374 -18.04911 25.58655  1.000 33.86766 ? 2   SER A OG  1 
ATOM   11   N N   . HIS A 1 3   ? -15.75985 -18.10395 23.42109  1.000 22.09666 ? 3   HIS A N   1 
ATOM   12   C CA  . HIS A 1 3   ? -15.51527 -18.63016 22.08774  1.000 19.80555 ? 3   HIS A CA  1 
ATOM   13   C C   . HIS A 1 3   ? -15.21275 -20.11199 22.19204  1.000 20.35350 ? 3   HIS A C   1 
ATOM   14   O O   . HIS A 1 3   ? -14.88766 -20.61666 23.26807  1.000 21.84895 ? 3   HIS A O   1 
ATOM   15   C CB  . HIS A 1 3   ? -14.36394 -17.88851 21.42819  1.000 19.60955 ? 3   HIS A CB  1 
ATOM   16   C CG  . HIS A 1 3   ? -14.66073 -16.44902 21.17794  1.000 24.89955 ? 3   HIS A CG  1 
ATOM   17   N ND1 . HIS A 1 3   ? -15.40200 -16.02550 20.09770  1.000 27.28314 ? 3   HIS A ND1 1 
ATOM   18   C CD2 . HIS A 1 3   ? -14.34067 -15.33628 21.87732  1.000 25.89002 ? 3   HIS A CD2 1 
ATOM   19   C CE1 . HIS A 1 3   ? -15.51956 -14.70932 20.13819  1.000 27.95327 ? 3   HIS A CE1 1 
ATOM   20   N NE2 . HIS A 1 3   ? -14.88328 -14.26701 21.20639  1.000 24.74692 ? 3   HIS A NE2 1 
ATOM   21   N N   . SER A 1 4   ? -15.32679 -20.80303 21.06144  1.000 15.41137 ? 4   SER A N   1 
ATOM   22   C CA  . SER A 1 4   ? -15.13570 -22.24310 21.00711  1.000 14.24588 ? 4   SER A CA  1 
ATOM   23   C C   . SER A 1 4   ? -14.33047 -22.60353 19.76895  1.000 16.32568 ? 4   SER A C   1 
ATOM   24   O O   . SER A 1 4   ? -14.36010 -21.89021 18.75470  1.000 18.73192 ? 4   SER A O   1 
ATOM   25   C CB  . SER A 1 4   ? -16.48463 -22.98474 20.96780  1.000 18.57639 ? 4   SER A CB  1 
ATOM   26   O OG  . SER A 1 4   ? -17.20676 -22.64335 19.78029  1.000 18.66768 ? 4   SER A OG  1 
ATOM   27   N N   . MET A 1 5   ? -13.62919 -23.73693 19.84657  1.000 12.20531 ? 5   MET A N   1 
ATOM   28   C CA  . MET A 1 5   ? -13.07554 -24.36251 18.66430  1.000 14.07775 ? 5   MET A CA  1 
ATOM   29   C C   . MET A 1 5   ? -13.51526 -25.81121 18.74442  1.000 13.79718 ? 5   MET A C   1 
ATOM   30   O O   . MET A 1 5   ? -13.55934 -26.39048 19.83592  1.000 11.73581 ? 5   MET A O   1 
ATOM   31   C CB  . MET A 1 5   ? -11.54646 -24.20089 18.62283  1.000 13.06698 ? 5   MET A CB  1 
ATOM   32   C CG  . MET A 1 5   ? -10.75724 -25.16800 17.76433  1.000 19.48548 ? 5   MET A CG  1 
ATOM   33   S SD  . MET A 1 5   ? -9.20254  -24.35768 17.25236  1.000 20.36687 ? 5   MET A SD  1 
ATOM   34   C CE  . MET A 1 5   ? -8.14405  -25.17503 18.46125  1.000 20.63855 ? 5   MET A CE  1 
ATOM   35   N N   . ARG A 1 6   ? -13.94269 -26.35890 17.61516  1.000 10.01993 ? 6   ARG A N   1 
ATOM   36   C CA  . ARG A 1 6   ? -14.31743 -27.75885 17.55387  1.000 11.40611 ? 6   ARG A CA  1 
ATOM   37   C C   . ARG A 1 6   ? -13.74771 -28.38333 16.29979  1.000 13.67793 ? 6   ARG A C   1 
ATOM   38   O O   . ARG A 1 6   ? -13.75038 -27.75437 15.23543  1.000 15.15037 ? 6   ARG A O   1 
ATOM   39   C CB  . ARG A 1 6   ? -15.83251 -27.95349 17.53619  1.000 14.89922 ? 6   ARG A CB  1 
ATOM   40   C CG  . ARG A 1 6   ? -16.53489 -27.31640 18.69314  1.000 15.74070 ? 6   ARG A CG  1 
ATOM   41   C CD  . ARG A 1 6   ? -16.65034 -28.33607 19.81257  1.000 20.56945 ? 6   ARG A CD  1 
ATOM   42   N NE  . ARG A 1 6   ? -17.45058 -27.83147 20.91676  1.000 18.92383 ? 6   ARG A NE  1 
ATOM   43   C CZ  . ARG A 1 6   ? -17.05187 -26.91978 21.79152  1.000 16.98116 ? 6   ARG A CZ  1 
ATOM   44   N NH1 . ARG A 1 6   ? -15.80170 -26.47655 21.81486  1.000 13.62725 ? 6   ARG A NH1 1 
ATOM   45   N NH2 . ARG A 1 6   ? -17.93197 -26.43560 22.66322  1.000 18.44680 ? 6   ARG A NH2 1 
ATOM   46   N N   . TYR A 1 7   ? -13.33974 -29.64184 16.42212  1.000 13.15414 ? 7   TYR A N   1 
ATOM   47   C CA  . TYR A 1 7   ? -13.08585 -30.50436 15.28552  1.000 14.36958 ? 7   TYR A CA  1 
ATOM   48   C C   . TYR A 1 7   ? -14.07597 -31.66123 15.30532  1.000 17.34827 ? 7   TYR A C   1 
ATOM   49   O O   . TYR A 1 7   ? -14.25151 -32.32220 16.33543  1.000 15.98893 ? 7   TYR A O   1 
ATOM   50   C CB  . TYR A 1 7   ? -11.64855 -31.02397 15.30756  1.000 15.29545 ? 7   TYR A CB  1 
ATOM   51   C CG  . TYR A 1 7   ? -10.61817 -29.98929 14.98060  1.000 15.03910 ? 7   TYR A CG  1 
ATOM   52   C CD1 . TYR A 1 7   ? -10.32571 -29.64291 13.65606  1.000 13.88234 ? 7   TYR A CD1 1 
ATOM   53   C CD2 . TYR A 1 7   ? -9.92111  -29.35099 15.99676  1.000 16.41617 ? 7   TYR A CD2 1 
ATOM   54   C CE1 . TYR A 1 7   ? -9.36042  -28.67819 13.36772  1.000 14.14193 ? 7   TYR A CE1 1 
ATOM   55   C CE2 . TYR A 1 7   ? -8.96044  -28.40739 15.72106  1.000 14.85126 ? 7   TYR A CE2 1 
ATOM   56   C CZ  . TYR A 1 7   ? -8.68243  -28.07570 14.41722  1.000 17.31906 ? 7   TYR A CZ  1 
ATOM   57   O OH  . TYR A 1 7   ? -7.71891  -27.14343 14.17968  1.000 19.52701 ? 7   TYR A OH  1 
ATOM   58   N N   . PHE A 1 8   ? -14.73906 -31.88565 14.17378  1.000 13.09539 ? 8   PHE A N   1 
ATOM   59   C CA  . PHE A 1 8   ? -15.68502 -32.98014 14.00802  1.000 14.38789 ? 8   PHE A CA  1 
ATOM   60   C C   . PHE A 1 8   ? -15.13128 -33.97733 13.00118  1.000 16.68977 ? 8   PHE A C   1 
ATOM   61   O O   . PHE A 1 8   ? -14.78405 -33.58456 11.87871  1.000 15.00054 ? 8   PHE A O   1 
ATOM   62   C CB  . PHE A 1 8   ? -17.03205 -32.44634 13.50160  1.000 16.69825 ? 8   PHE A CB  1 
ATOM   63   C CG  . PHE A 1 8   ? -17.62573 -31.35595 14.34758  1.000 18.81037 ? 8   PHE A CG  1 
ATOM   64   C CD1 . PHE A 1 8   ? -17.91747 -31.56691 15.68055  1.000 21.76749 ? 8   PHE A CD1 1 
ATOM   65   C CD2 . PHE A 1 8   ? -17.88543 -30.11126 13.81032  1.000 23.84700 ? 8   PHE A CD2 1 
ATOM   66   C CE1 . PHE A 1 8   ? -18.49062 -30.55587 16.45796  1.000 24.48596 ? 8   PHE A CE1 1 
ATOM   67   C CE2 . PHE A 1 8   ? -18.45084 -29.09197 14.59349  1.000 26.95111 ? 8   PHE A CE2 1 
ATOM   68   C CZ  . PHE A 1 8   ? -18.73329 -29.31744 15.92006  1.000 21.17970 ? 8   PHE A CZ  1 
ATOM   69   N N   . SER A 1 9   ? -15.07795 -35.25996 13.36853  1.000 14.67822 ? 9   SER A N   1 
ATOM   70   C CA  . SER A 1 9   ? -14.70360 -36.29021 12.40721  1.000 16.33063 ? 9   SER A CA  1 
ATOM   71   C C   . SER A 1 9   ? -15.79857 -37.34162 12.29384  1.000 15.23256 ? 9   SER A C   1 
ATOM   72   O O   . SER A 1 9   ? -16.46917 -37.66330 13.27485  1.000 16.60634 ? 9   SER A O   1 
ATOM   73   C CB  . SER A 1 9   ? -13.38733 -36.98855 12.77210  1.000 19.93600 ? 9   SER A CB  1 
ATOM   74   O OG  . SER A 1 9   ? -13.47511 -37.67633 14.00627  1.000 23.16570 ? 9   SER A OG  1 
ATOM   75   N N   . THR A 1 10  ? -15.94462 -37.89143 11.08361  1.000 16.28876 ? 10  THR A N   1 
ATOM   76   C CA  . THR A 1 10  ? -16.87540 -38.97671 10.77014  1.000 16.39060 ? 10  THR A CA  1 
ATOM   77   C C   . THR A 1 10  ? -16.14321 -40.06978 9.99203   1.000 19.61312 ? 10  THR A C   1 
ATOM   78   O O   . THR A 1 10  ? -15.64048 -39.81183 8.89099   1.000 16.88377 ? 10  THR A O   1 
ATOM   79   C CB  . THR A 1 10  ? -18.07308 -38.45230 9.95258   1.000 18.26181 ? 10  THR A CB  1 
ATOM   80   O OG1 . THR A 1 10  ? -18.69830 -37.33530 10.62022  1.000 18.47500 ? 10  THR A OG1 1 
ATOM   81   C CG2 . THR A 1 10  ? -19.11871 -39.54987 9.74720   1.000 13.30752 ? 10  THR A CG2 1 
ATOM   82   N N   . SER A 1 11  ? -16.09682 -41.28975 10.54203  1.000 16.41352 ? 11  SER A N   1 
ATOM   83   C CA  . SER A 1 11  ? -15.61386 -42.46647 9.81967   1.000 17.21980 ? 11  SER A CA  1 
ATOM   84   C C   . SER A 1 11  ? -16.78073 -43.39117 9.50308   1.000 20.50269 ? 11  SER A C   1 
ATOM   85   O O   . SER A 1 11  ? -17.55851 -43.74609 10.39933  1.000 15.18532 ? 11  SER A O   1 
ATOM   86   C CB  . SER A 1 11  ? -14.56774 -43.23612 10.62826  1.000 16.87666 ? 11  SER A CB  1 
ATOM   87   O OG  . SER A 1 11  ? -13.43722 -42.43575 10.86211  1.000 25.01964 ? 11  SER A OG  1 
ATOM   88   N N   . VAL A 1 12  ? -16.90746 -43.78100 8.23777   1.000 18.21497 ? 12  VAL A N   1 
ATOM   89   C CA  . VAL A 1 12  ? -18.01476 -44.62115 7.79206   1.000 18.78487 ? 12  VAL A CA  1 
ATOM   90   C C   . VAL A 1 12  ? -17.42762 -45.80171 7.03261   1.000 23.11766 ? 12  VAL A C   1 
ATOM   91   O O   . VAL A 1 12  ? -16.76504 -45.61026 6.00996   1.000 20.88585 ? 12  VAL A O   1 
ATOM   92   C CB  . VAL A 1 12  ? -19.00825 -43.84382 6.90736   1.000 21.39770 ? 12  VAL A CB  1 
ATOM   93   C CG1 . VAL A 1 12  ? -20.17859 -44.71525 6.47012   1.000 23.25459 ? 12  VAL A CG1 1 
ATOM   94   C CG2 . VAL A 1 12  ? -19.51358 -42.58634 7.61806   1.000 20.07377 ? 12  VAL A CG2 1 
ATOM   95   N N   . SER A 1 13  ? -17.67174 -47.01548 7.51813   1.000 22.23462 ? 13  SER A N   1 
ATOM   96   C CA  . SER A 1 13  ? -17.23594 -48.20321 6.79367   1.000 26.79082 ? 13  SER A CA  1 
ATOM   97   C C   . SER A 1 13  ? -18.13993 -48.45257 5.58816   1.000 26.86092 ? 13  SER A C   1 
ATOM   98   O O   . SER A 1 13  ? -19.35288 -48.25608 5.65359   1.000 25.84415 ? 13  SER A O   1 
ATOM   99   C CB  . SER A 1 13  ? -17.23814 -49.42370 7.71493   1.000 22.92871 ? 13  SER A CB  1 
ATOM   100  O OG  . SER A 1 13  ? -18.51993 -49.59331 8.27619   1.000 25.29689 ? 13  SER A OG  1 
ATOM   101  N N   . ARG A 1 14  ? -17.53736 -48.88698 4.47932   1.000 28.16883 ? 14  ARG A N   1 
ATOM   102  C CA  . ARG A 1 14  ? -18.25564 -49.18979 3.24032   1.000 30.57720 ? 14  ARG A CA  1 
ATOM   103  C C   . ARG A 1 14  ? -17.88743 -50.60691 2.82421   1.000 40.22344 ? 14  ARG A C   1 
ATOM   104  O O   . ARG A 1 14  ? -17.04531 -50.80196 1.93311   1.000 32.69714 ? 14  ARG A O   1 
ATOM   105  C CB  . ARG A 1 14  ? -17.87611 -48.21892 2.12569   1.000 33.30472 ? 14  ARG A CB  1 
ATOM   106  C CG  . ARG A 1 14  ? -17.80591 -46.77900 2.52715   1.000 32.22516 ? 14  ARG A CG  1 
ATOM   107  C CD  . ARG A 1 14  ? -17.36146 -45.96181 1.33320   1.000 33.34031 ? 14  ARG A CD  1 
ATOM   108  N NE  . ARG A 1 14  ? -15.91632 -45.77150 1.36435   1.000 30.88577 ? 14  ARG A NE  1 
ATOM   109  C CZ  . ARG A 1 14  ? -15.27534 -44.81252 0.71401   1.000 30.93891 ? 14  ARG A CZ  1 
ATOM   110  N NH1 . ARG A 1 14  ? -15.91526 -43.96647 -0.08196  1.000 28.05974 ? 14  ARG A NH1 1 
ATOM   111  N NH2 . ARG A 1 14  ? -13.96084 -44.69889 0.86305   1.000 31.95524 ? 14  ARG A NH2 1 
ATOM   112  N N   . PRO A 1 15  ? -18.48454 -51.61892 3.45150   1.000 35.58346 ? 15  PRO A N   1 
ATOM   113  C CA  . PRO A 1 15  ? -18.07205 -53.00474 3.17450   1.000 40.71326 ? 15  PRO A CA  1 
ATOM   114  C C   . PRO A 1 15  ? -18.24402 -53.35069 1.70315   1.000 38.21276 ? 15  PRO A C   1 
ATOM   115  O O   . PRO A 1 15  ? -19.27061 -53.04550 1.09084   1.000 37.13930 ? 15  PRO A O   1 
ATOM   116  C CB  . PRO A 1 15  ? -19.00797 -53.83431 4.06204   1.000 40.13976 ? 15  PRO A CB  1 
ATOM   117  C CG  . PRO A 1 15  ? -19.39874 -52.89598 5.15192   1.000 34.87940 ? 15  PRO A CG  1 
ATOM   118  C CD  . PRO A 1 15  ? -19.52095 -51.55676 4.49323   1.000 34.10147 ? 15  PRO A CD  1 
ATOM   119  N N   . GLY A 1 16  ? -17.22178 -53.98926 1.13844   1.000 38.65839 ? 16  GLY A N   1 
ATOM   120  C CA  . GLY A 1 16  ? -17.22018 -54.30056 -0.27537  1.000 39.79941 ? 16  GLY A CA  1 
ATOM   121  C C   . GLY A 1 16  ? -17.02688 -53.11813 -1.19785  1.000 43.44248 ? 16  GLY A C   1 
ATOM   122  O O   . GLY A 1 16  ? -17.21973 -53.26349 -2.40800  1.000 43.97843 ? 16  GLY A O   1 
ATOM   123  N N   . ARG A 1 17  ? -16.65420 -51.94404 -0.67292  1.000 38.84623 ? 17  ARG A N   1 
ATOM   124  C CA  . ARG A 1 17  ? -16.50112 -50.76172 -1.51525  1.000 41.25783 ? 17  ARG A CA  1 
ATOM   125  C C   . ARG A 1 17  ? -15.30456 -49.91993 -1.09232  1.000 41.24656 ? 17  ARG A C   1 
ATOM   126  O O   . ARG A 1 17  ? -15.31831 -48.69529 -1.25349  1.000 43.41706 ? 17  ARG A O   1 
ATOM   127  C CB  . ARG A 1 17  ? -17.74834 -49.88476 -1.49083  1.000 39.94801 ? 17  ARG A CB  1 
ATOM   128  C CG  . ARG A 1 17  ? -19.00575 -50.49046 -2.08128  1.000 44.67883 ? 17  ARG A CG  1 
ATOM   129  C CD  . ARG A 1 17  ? -20.06554 -50.35941 -1.03436  1.000 46.34491 ? 17  ARG A CD  1 
ATOM   130  N NE  . ARG A 1 17  ? -21.43404 -50.63066 -1.45479  1.000 52.51644 ? 17  ARG A NE  1 
ATOM   131  C CZ  . ARG A 1 17  ? -22.28238 -49.69637 -1.86552  1.000 51.18413 ? 17  ARG A CZ  1 
ATOM   132  N NH1 . ARG A 1 17  ? -21.88017 -48.45719 -2.10977  1.000 52.19945 ? 17  ARG A NH1 1 
ATOM   133  N NH2 . ARG A 1 17  ? -23.57020 -50.00479 -2.00690  1.000 39.25090 ? 17  ARG A NH2 1 
ATOM   134  N N   . GLY A 1 18  ? -14.27237 -50.54516 -0.54452  1.000 37.83943 ? 18  GLY A N   1 
ATOM   135  C CA  . GLY A 1 18  ? -13.05651 -49.83999 -0.18633  1.000 41.56448 ? 18  GLY A CA  1 
ATOM   136  C C   . GLY A 1 18  ? -12.95023 -49.61120 1.30781   1.000 37.48317 ? 18  GLY A C   1 
ATOM   137  O O   . GLY A 1 18  ? -13.79028 -50.04210 2.10411   1.000 37.54350 ? 18  GLY A O   1 
ATOM   138  N N   . GLU A 1 19  ? -11.87562 -48.91191 1.67202   1.000 34.23408 ? 19  GLU A N   1 
ATOM   139  C CA  . GLU A 1 19  ? -11.56272 -48.59278 3.05825   1.000 34.06646 ? 19  GLU A CA  1 
ATOM   140  C C   . GLU A 1 19  ? -12.59703 -47.58514 3.57328   1.000 32.58184 ? 19  GLU A C   1 
ATOM   141  O O   . GLU A 1 19  ? -13.23734 -46.88591 2.78223   1.000 29.46116 ? 19  GLU A O   1 
ATOM   142  C CB  . GLU A 1 19  ? -10.14408 -48.01265 3.12315   1.000 37.12132 ? 19  GLU A CB  1 
ATOM   143  C CG  . GLU A 1 19  ? -9.01443  -48.89161 3.72605   1.000 39.44825 ? 19  GLU A CG  1 
ATOM   144  C CD  . GLU A 1 19  ? -9.38471  -49.66820 4.98193   1.000 45.66504 ? 19  GLU A CD  1 
ATOM   145  O OE1 . GLU A 1 19  ? -9.47276  -49.04085 6.06541   1.000 46.85219 ? 19  GLU A OE1 1 
ATOM   146  O OE2 . GLU A 1 19  ? -9.59938  -50.89886 4.88966   1.000 42.84727 ? 19  GLU A OE2 1 
ATOM   147  N N   . PRO A 1 20  ? -12.78878 -47.49021 4.88913   1.000 31.76504 ? 20  PRO A N   1 
ATOM   148  C CA  . PRO A 1 20  ? -13.75775 -46.51556 5.40730   1.000 29.15535 ? 20  PRO A CA  1 
ATOM   149  C C   . PRO A 1 20  ? -13.44014 -45.08222 5.00710   1.000 26.63323 ? 20  PRO A C   1 
ATOM   150  O O   . PRO A 1 20  ? -12.28302 -44.65502 4.97655   1.000 23.91582 ? 20  PRO A O   1 
ATOM   151  C CB  . PRO A 1 20  ? -13.69342 -46.70683 6.92925   1.000 24.22414 ? 20  PRO A CB  1 
ATOM   152  C CG  . PRO A 1 20  ? -12.68702 -47.79965 7.17733   1.000 31.50422 ? 20  PRO A CG  1 
ATOM   153  C CD  . PRO A 1 20  ? -12.41938 -48.49088 5.90071   1.000 29.19136 ? 20  PRO A CD  1 
ATOM   154  N N   . ARG A 1 21  ? -14.49788 -44.34068 4.68725   1.000 21.95539 ? 21  ARG A N   1 
ATOM   155  C CA  . ARG A 1 21  ? -14.36032 -42.92715 4.38953   1.000 22.47267 ? 21  ARG A CA  1 
ATOM   156  C C   . ARG A 1 21  ? -14.28492 -42.10853 5.67160   1.000 23.89698 ? 21  ARG A C   1 
ATOM   157  O O   . ARG A 1 21  ? -15.05362 -42.32066 6.61803   1.000 20.35614 ? 21  ARG A O   1 
ATOM   158  C CB  . ARG A 1 21  ? -15.51824 -42.43701 3.53560   1.000 24.61014 ? 21  ARG A CB  1 
ATOM   159  C CG  . ARG A 1 21  ? -15.26719 -41.04475 3.00768   1.000 26.07379 ? 21  ARG A CG  1 
ATOM   160  C CD  . ARG A 1 21  ? -16.35934 -40.61385 2.09772   1.000 26.43771 ? 21  ARG A CD  1 
ATOM   161  N NE  . ARG A 1 21  ? -16.06695 -39.31772 1.50194   1.000 28.19995 ? 21  ARG A NE  1 
ATOM   162  C CZ  . ARG A 1 21  ? -16.92538 -38.66697 0.73324   1.000 28.68882 ? 21  ARG A CZ  1 
ATOM   163  N NH1 . ARG A 1 21  ? -18.08005 -39.20991 0.37821   1.000 26.44833 ? 21  ARG A NH1 1 
ATOM   164  N NH2 . ARG A 1 21  ? -16.63625 -37.43197 0.33700   1.000 26.30747 ? 21  ARG A NH2 1 
ATOM   165  N N   . PHE A 1 22  ? -13.34612 -41.16578 5.69291   1.000 19.68604 ? 22  PHE A N   1 
ATOM   166  C CA  . PHE A 1 22  ? -13.08354 -40.31403 6.85016   1.000 15.99419 ? 22  PHE A CA  1 
ATOM   167  C C   . PHE A 1 22  ? -13.18396 -38.86877 6.40558   1.000 18.44093 ? 22  PHE A C   1 
ATOM   168  O O   . PHE A 1 22  ? -12.51338 -38.46675 5.44746   1.000 18.12862 ? 22  PHE A O   1 
ATOM   169  C CB  . PHE A 1 22  ? -11.69072 -40.58891 7.43184   1.000 19.41647 ? 22  PHE A CB  1 
ATOM   170  C CG  . PHE A 1 22  ? -11.29040 -39.66561 8.55639   1.000 17.12908 ? 22  PHE A CG  1 
ATOM   171  C CD1 . PHE A 1 22  ? -11.59930 -39.97802 9.87828   1.000 17.89820 ? 22  PHE A CD1 1 
ATOM   172  C CD2 . PHE A 1 22  ? -10.56758 -38.49667 8.29601   1.000 17.86314 ? 22  PHE A CD2 1 
ATOM   173  C CE1 . PHE A 1 22  ? -11.19961 -39.13650 10.91547  1.000 17.53135 ? 22  PHE A CE1 1 
ATOM   174  C CE2 . PHE A 1 22  ? -10.17543 -37.64890 9.33141   1.000 17.03134 ? 22  PHE A CE2 1 
ATOM   175  C CZ  . PHE A 1 22  ? -10.49622 -37.96707 10.63707  1.000 15.98355 ? 22  PHE A CZ  1 
ATOM   176  N N   . ILE A 1 23  ? -14.02719 -38.09801 7.08806   1.000 12.54158 ? 23  ILE A N   1 
ATOM   177  C CA  . ILE A 1 23  ? -14.20271 -36.67418 6.84044   1.000 11.29080 ? 23  ILE A CA  1 
ATOM   178  C C   . ILE A 1 23  ? -14.06631 -35.94077 8.16479   1.000 17.57077 ? 23  ILE A C   1 
ATOM   179  O O   . ILE A 1 23  ? -14.74255 -36.29524 9.14211   1.000 18.74443 ? 23  ILE A O   1 
ATOM   180  C CB  . ILE A 1 23  ? -15.57650 -36.37674 6.20513   1.000 16.29632 ? 23  ILE A CB  1 
ATOM   181  C CG1 . ILE A 1 23  ? -15.72909 -37.12342 4.88514   1.000 18.26109 ? 23  ILE A CG1 1 
ATOM   182  C CG2 . ILE A 1 23  ? -15.75637 -34.88742 5.99176   1.000 14.11319 ? 23  ILE A CG2 1 
ATOM   183  C CD1 . ILE A 1 23  ? -17.01345 -36.77006 4.15818   1.000 21.60732 ? 23  ILE A CD1 1 
ATOM   184  N N   . ALA A 1 24  ? -13.20677 -34.91569 8.19984   1.000 13.34344 ? 24  ALA A N   1 
ATOM   185  C CA  . ALA A 1 24  ? -13.05657 -34.07560 9.38094   1.000 13.74978 ? 24  ALA A CA  1 
ATOM   186  C C   . ALA A 1 24  ? -13.18265 -32.60563 8.99105   1.000 17.40729 ? 24  ALA A C   1 
ATOM   187  O O   . ALA A 1 24  ? -12.77160 -32.21170 7.89481   1.000 14.40032 ? 24  ALA A O   1 
ATOM   188  C CB  . ALA A 1 24  ? -11.71076 -34.31132 10.08045  1.000 17.93090 ? 24  ALA A CB  1 
ATOM   189  N N   . VAL A 1 25  ? -13.79101 -31.80439 9.87733   1.000 12.33733 ? 25  VAL A N   1 
ATOM   190  C CA  . VAL A 1 25  ? -13.92424 -30.36351 9.68625   1.000 11.90566 ? 25  VAL A CA  1 
ATOM   191  C C   . VAL A 1 25  ? -13.55193 -29.65498 10.98181  1.000 12.09591 ? 25  VAL A C   1 
ATOM   192  O O   . VAL A 1 25  ? -13.62551 -30.23565 12.06208  1.000 14.56274 ? 25  VAL A O   1 
ATOM   193  C CB  . VAL A 1 25  ? -15.34393 -29.97110 9.23628   1.000 14.26425 ? 25  VAL A CB  1 
ATOM   194  C CG1 . VAL A 1 25  ? -15.62327 -30.49116 7.84605   1.000 18.18750 ? 25  VAL A CG1 1 
ATOM   195  C CG2 . VAL A 1 25  ? -16.40744 -30.47694 10.23979  1.000 12.59560 ? 25  VAL A CG2 1 
ATOM   196  N N   . GLY A 1 26  ? -13.11431 -28.40397 10.87193  1.000 12.77416 ? 26  GLY A N   1 
ATOM   197  C CA  . GLY A 1 26  ? -12.83027 -27.59440 12.04211  1.000 13.55546 ? 26  GLY A CA  1 
ATOM   198  C C   . GLY A 1 26  ? -13.57311 -26.27516 11.98159  1.000 15.84145 ? 26  GLY A C   1 
ATOM   199  O O   . GLY A 1 26  ? -13.77395 -25.69807 10.91169  1.000 15.54350 ? 26  GLY A O   1 
ATOM   200  N N   . TYR A 1 27  ? -13.93160 -25.77766 13.16537  1.000 14.27978 ? 27  TYR A N   1 
ATOM   201  C CA  . TYR A 1 27  ? -14.77264 -24.60269 13.35488  1.000 16.20749 ? 27  TYR A CA  1 
ATOM   202  C C   . TYR A 1 27  ? -14.19056 -23.73776 14.45600  1.000 12.30625 ? 27  TYR A C   1 
ATOM   203  O O   . TYR A 1 27  ? -13.79633 -24.24953 15.50282  1.000 14.91575 ? 27  TYR A O   1 
ATOM   204  C CB  . TYR A 1 27  ? -16.21064 -24.97949 13.79578  1.000 12.86459 ? 27  TYR A CB  1 
ATOM   205  C CG  . TYR A 1 27  ? -17.14126 -25.41488 12.68085  1.000 18.70792 ? 27  TYR A CG  1 
ATOM   206  C CD1 . TYR A 1 27  ? -17.89781 -24.48159 11.98619  1.000 16.35837 ? 27  TYR A CD1 1 
ATOM   207  C CD2 . TYR A 1 27  ? -17.27770 -26.75617 12.34324  1.000 21.11637 ? 27  TYR A CD2 1 
ATOM   208  C CE1 . TYR A 1 27  ? -18.74054 -24.87089 10.95497  1.000 18.88388 ? 27  TYR A CE1 1 
ATOM   209  C CE2 . TYR A 1 27  ? -18.12663 -27.16418 11.31791  1.000 20.53649 ? 27  TYR A CE2 1 
ATOM   210  C CZ  . TYR A 1 27  ? -18.85569 -26.21717 10.63390  1.000 20.72403 ? 27  TYR A CZ  1 
ATOM   211  O OH  . TYR A 1 27  ? -19.68694 -26.61626 9.61942   1.000 21.54844 ? 27  TYR A OH  1 
ATOM   212  N N   . VAL A 1 28  ? -14.19354 -22.43076 14.25376  1.000 14.17885 ? 28  VAL A N   1 
ATOM   213  C CA  . VAL A 1 28  ? -14.13207 -21.48972 15.36314  1.000 10.45608 ? 28  VAL A CA  1 
ATOM   214  C C   . VAL A 1 28  ? -15.51707 -20.86441 15.45567  1.000 15.91756 ? 28  VAL A C   1 
ATOM   215  O O   . VAL A 1 28  ? -15.99630 -20.28364 14.47422  1.000 14.56871 ? 28  VAL A O   1 
ATOM   216  C CB  . VAL A 1 28  ? -13.05365 -20.42718 15.15300  1.000 13.46216 ? 28  VAL A CB  1 
ATOM   217  C CG1 . VAL A 1 28  ? -13.17426 -19.32561 16.22391  1.000 12.91425 ? 28  VAL A CG1 1 
ATOM   218  C CG2 . VAL A 1 28  ? -11.65973 -21.08631 15.16999  1.000 14.47514 ? 28  VAL A CG2 1 
ATOM   219  N N   . ASP A 1 29  ? -16.16306 -20.99368 16.62405  1.000 15.06876 ? 29  ASP A N   1 
ATOM   220  C CA  . ASP A 1 29  ? -17.54948 -20.55749 16.79433  1.000 16.75436 ? 29  ASP A CA  1 
ATOM   221  C C   . ASP A 1 29  ? -18.41743 -21.15242 15.68717  1.000 16.46930 ? 29  ASP A C   1 
ATOM   222  O O   . ASP A 1 29  ? -18.43829 -22.37127 15.52730  1.000 15.70098 ? 29  ASP A O   1 
ATOM   223  C CB  . ASP A 1 29  ? -17.63705 -19.03100 16.81937  1.000 16.72381 ? 29  ASP A CB  1 
ATOM   224  C CG  . ASP A 1 29  ? -16.88641 -18.44031 17.99187  1.000 19.49160 ? 29  ASP A CG  1 
ATOM   225  O OD1 . ASP A 1 29  ? -16.82315 -19.11638 19.04750  1.000 20.65204 ? 29  ASP A OD1 1 
ATOM   226  O OD2 . ASP A 1 29  ? -16.34874 -17.32212 17.85501  1.000 25.04981 ? 29  ASP A OD2 1 
ATOM   227  N N   . ASP A 1 30  ? -19.11909 -20.32385 14.90604  1.000 18.53476 ? 30  ASP A N   1 
ATOM   228  C CA  . ASP A 1 30  ? -19.98216 -20.82017 13.83331  1.000 16.50599 ? 30  ASP A CA  1 
ATOM   229  C C   . ASP A 1 30  ? -19.33326 -20.69431 12.46265  1.000 20.69783 ? 30  ASP A C   1 
ATOM   230  O O   . ASP A 1 30  ? -20.04323 -20.60998 11.45213  1.000 19.90158 ? 30  ASP A O   1 
ATOM   231  C CB  . ASP A 1 30  ? -21.32999 -20.09602 13.82969  1.000 21.52235 ? 30  ASP A CB  1 
ATOM   232  C CG  . ASP A 1 30  ? -22.16294 -20.41976 15.04958  1.000 21.87177 ? 30  ASP A CG  1 
ATOM   233  O OD1 . ASP A 1 30  ? -22.23785 -21.61838 15.39477  1.000 28.25262 ? 30  ASP A OD1 1 
ATOM   234  O OD2 . ASP A 1 30  ? -22.69835 -19.47608 15.67501  1.000 20.69082 ? 30  ASP A OD2 1 
ATOM   235  N N   . THR A 1 31  ? -17.99786 -20.67785 12.41012  1.000 20.76917 ? 31  THR A N   1 
ATOM   236  C CA  . THR A 1 31  ? -17.23526 -20.40750 11.19162  1.000 17.79069 ? 31  THR A CA  1 
ATOM   237  C C   . THR A 1 31  ? -16.32292 -21.60021 10.91664  1.000 18.58634 ? 31  THR A C   1 
ATOM   238  O O   . THR A 1 31  ? -15.43622 -21.90555 11.72041  1.000 14.24900 ? 31  THR A O   1 
ATOM   239  C CB  . THR A 1 31  ? -16.40807 -19.12082 11.32834  1.000 19.17453 ? 31  THR A CB  1 
ATOM   240  O OG1 . THR A 1 31  ? -17.27785 -17.99131 11.47216  1.000 17.45348 ? 31  THR A OG1 1 
ATOM   241  C CG2 . THR A 1 31  ? -15.52117 -18.90120 10.09094  1.000 19.19531 ? 31  THR A CG2 1 
ATOM   242  N N   . GLN A 1 32  ? -16.56934 -22.30119 9.81325   1.000 17.65776 ? 32  GLN A N   1 
ATOM   243  C CA  . GLN A 1 32  ? -15.68894 -23.39689 9.44678   1.000 21.62795 ? 32  GLN A CA  1 
ATOM   244  C C   . GLN A 1 32  ? -14.36763 -22.81358 8.96878   1.000 14.90616 ? 32  GLN A C   1 
ATOM   245  O O   . GLN A 1 32  ? -14.33518 -21.72843 8.38607   1.000 16.42020 ? 32  GLN A O   1 
ATOM   246  C CB  . GLN A 1 32  ? -16.33462 -24.25841 8.35929   1.000 18.56000 ? 32  GLN A CB  1 
ATOM   247  C CG  . GLN A 1 32  ? -15.59928 -25.55917 8.10089   1.000 16.47851 ? 32  GLN A CG  1 
ATOM   248  C CD  . GLN A 1 32  ? -16.02601 -26.23844 6.80537   1.000 18.78367 ? 32  GLN A CD  1 
ATOM   249  O OE1 . GLN A 1 32  ? -17.09863 -25.96383 6.26020   1.000 23.37283 ? 32  GLN A OE1 1 
ATOM   250  N NE2 . GLN A 1 32  ? -15.17777 -27.12846 6.30581   1.000 17.70460 ? 32  GLN A NE2 1 
ATOM   251  N N   . PHE A 1 33  ? -13.25539 -23.51198 9.23741   1.000 15.01247 ? 33  PHE A N   1 
ATOM   252  C CA  . PHE A 1 33  ? -11.98405 -23.02738 8.70439   1.000 17.58070 ? 33  PHE A CA  1 
ATOM   253  C C   . PHE A 1 33  ? -11.08595 -24.07646 8.06656   1.000 18.30905 ? 33  PHE A C   1 
ATOM   254  O O   . PHE A 1 33  ? -10.22911 -23.68496 7.27466   1.000 18.09019 ? 33  PHE A O   1 
ATOM   255  C CB  . PHE A 1 33  ? -11.18128 -22.24452 9.76860   1.000 17.79292 ? 33  PHE A CB  1 
ATOM   256  C CG  . PHE A 1 33  ? -10.63908 -23.08433 10.90773  1.000 16.32769 ? 33  PHE A CG  1 
ATOM   257  C CD1 . PHE A 1 33  ? -11.48450 -23.55633 11.91679  1.000 19.07034 ? 33  PHE A CD1 1 
ATOM   258  C CD2 . PHE A 1 33  ? -9.28212  -23.34435 10.99606  1.000 17.40671 ? 33  PHE A CD2 1 
ATOM   259  C CE1 . PHE A 1 33  ? -10.98334 -24.31205 12.95488  1.000 14.03691 ? 33  PHE A CE1 1 
ATOM   260  C CE2 . PHE A 1 33  ? -8.76899  -24.09183 12.03197  1.000 18.68036 ? 33  PHE A CE2 1 
ATOM   261  C CZ  . PHE A 1 33  ? -9.60600  -24.57376 13.01643  1.000 16.79524 ? 33  PHE A CZ  1 
ATOM   262  N N   . VAL A 1 34  ? -11.27469 -25.37893 8.32357   1.000 16.96558 ? 34  VAL A N   1 
ATOM   263  C CA  . VAL A 1 34  ? -10.52036 -26.42901 7.63940   1.000 19.53370 ? 34  VAL A CA  1 
ATOM   264  C C   . VAL A 1 34  ? -11.42285 -27.62802 7.35499   1.000 18.26510 ? 34  VAL A C   1 
ATOM   265  O O   . VAL A 1 34  ? -12.49356 -27.79311 7.94579   1.000 16.43448 ? 34  VAL A O   1 
ATOM   266  C CB  . VAL A 1 34  ? -9.27830  -26.90095 8.43414   1.000 15.10009 ? 34  VAL A CB  1 
ATOM   267  C CG1 . VAL A 1 34  ? -8.20069  -25.81178 8.46823   1.000 19.90337 ? 34  VAL A CG1 1 
ATOM   268  C CG2 . VAL A 1 34  ? -9.66349  -27.29383 9.84558   1.000 15.09636 ? 34  VAL A CG2 1 
ATOM   269  N N   . ARG A 1 35  ? -10.95024 -28.48380 6.45136   1.000 15.86883 ? 35  ARG A N   1 
ATOM   270  C CA  . ARG A 1 35  ? -11.60387 -29.73229 6.09159   1.000 14.05949 ? 35  ARG A CA  1 
ATOM   271  C C   . ARG A 1 35  ? -10.55312 -30.74766 5.65285   1.000 18.57636 ? 35  ARG A C   1 
ATOM   272  O O   . ARG A 1 35  ? -9.48143  -30.38055 5.15545   1.000 17.08849 ? 35  ARG A O   1 
ATOM   273  C CB  . ARG A 1 35  ? -12.63602 -29.51774 4.96435   1.000 17.96270 ? 35  ARG A CB  1 
ATOM   274  C CG  . ARG A 1 35  ? -12.03312 -29.67975 3.56676   1.000 18.90706 ? 35  ARG A CG  1 
ATOM   275  C CD  . ARG A 1 35  ? -13.06098 -29.66178 2.47382   1.000 22.40690 ? 35  ARG A CD  1 
ATOM   276  N NE  . ARG A 1 35  ? -12.45894 -29.39813 1.16749   1.000 26.39085 ? 35  ARG A NE  1 
ATOM   277  C CZ  . ARG A 1 35  ? -13.11667 -28.89312 0.13043   1.000 27.11505 ? 35  ARG A CZ  1 
ATOM   278  N NH1 . ARG A 1 35  ? -14.40789 -28.60004 0.20363   1.000 18.78160 ? 35  ARG A NH1 1 
ATOM   279  N NH2 . ARG A 1 35  ? -12.46254 -28.66474 -1.00642  1.000 21.16432 ? 35  ARG A NH2 1 
ATOM   280  N N   . PHE A 1 36  ? -10.86464 -32.03482 5.84723   1.000 18.70171 ? 36  PHE A N   1 
ATOM   281  C CA  . PHE A 1 36  ? -10.10587 -33.12934 5.25146   1.000 12.38696 ? 36  PHE A CA  1 
ATOM   282  C C   . PHE A 1 36  ? -11.09400 -34.19249 4.78478   1.000 18.10494 ? 36  PHE A C   1 
ATOM   283  O O   . PHE A 1 36  ? -12.05168 -34.51298 5.49467   1.000 13.54544 ? 36  PHE A O   1 
ATOM   284  C CB  . PHE A 1 36  ? -9.09414  -33.72882 6.23886   1.000 7.77045  ? 36  PHE A CB  1 
ATOM   285  C CG  . PHE A 1 36  ? -8.32045  -34.91127 5.69864   1.000 15.08062 ? 36  PHE A CG  1 
ATOM   286  C CD1 . PHE A 1 36  ? -7.15576  -34.71240 4.95891   1.000 11.89171 ? 36  PHE A CD1 1 
ATOM   287  C CD2 . PHE A 1 36  ? -8.74546  -36.22132 5.93786   1.000 15.18965 ? 36  PHE A CD2 1 
ATOM   288  C CE1 . PHE A 1 36  ? -6.43884  -35.79743 4.46351   1.000 16.54557 ? 36  PHE A CE1 1 
ATOM   289  C CE2 . PHE A 1 36  ? -8.03516  -37.30590 5.42997   1.000 13.25336 ? 36  PHE A CE2 1 
ATOM   290  C CZ  . PHE A 1 36  ? -6.86979  -37.07757 4.67972   1.000 11.20545 ? 36  PHE A CZ  1 
ATOM   291  N N   . ASP A 1 37  ? -10.87018 -34.73937 3.59007   1.000 9.70243  ? 37  ASP A N   1 
ATOM   292  C CA  . ASP A 1 37  ? -11.71196 -35.80181 3.04842   1.000 12.40197 ? 37  ASP A CA  1 
ATOM   293  C C   . ASP A 1 37  ? -10.80899 -36.90471 2.51399   1.000 17.85041 ? 37  ASP A C   1 
ATOM   294  O O   . ASP A 1 37  ? -10.04458 -36.68407 1.56273   1.000 17.70552 ? 37  ASP A O   1 
ATOM   295  C CB  . ASP A 1 37  ? -12.63531 -35.27872 1.94081   1.000 20.43464 ? 37  ASP A CB  1 
ATOM   296  C CG  . ASP A 1 37  ? -13.63363 -36.32415 1.46417   1.000 24.90464 ? 37  ASP A CG  1 
ATOM   297  O OD1 . ASP A 1 37  ? -13.49561 -37.50922 1.83373   1.000 24.07171 ? 37  ASP A OD1 1 
ATOM   298  O OD2 . ASP A 1 37  ? -14.54872 -35.97237 0.68938   1.000 29.13319 ? 37  ASP A OD2 1 
ATOM   299  N N   . SER A 1 38  ? -10.91347 -38.09341 3.10279   1.000 16.56959 ? 38  SER A N   1 
ATOM   300  C CA  . SER A 1 38  ? -10.02811 -39.17693 2.70502   1.000 18.80479 ? 38  SER A CA  1 
ATOM   301  C C   . SER A 1 38  ? -10.21962 -39.57520 1.24547   1.000 20.81115 ? 38  SER A C   1 
ATOM   302  O O   . SER A 1 38  ? -9.29195  -40.11971 0.64284   1.000 17.60697 ? 38  SER A O   1 
ATOM   303  C CB  . SER A 1 38  ? -10.21820 -40.36919 3.64409   1.000 21.16679 ? 38  SER A CB  1 
ATOM   304  O OG  . SER A 1 38  ? -11.45448 -41.02388 3.41393   1.000 22.12723 ? 38  SER A OG  1 
ATOM   305  N N   . ASP A 1 39  ? -11.37919 -39.30013 0.65181   1.000 21.32697 ? 39  ASP A N   1 
ATOM   306  C CA  . ASP A 1 39  ? -11.59309 -39.64779 -0.74762  1.000 21.43992 ? 39  ASP A CA  1 
ATOM   307  C C   . ASP A 1 39  ? -11.12052 -38.57661 -1.71530  1.000 27.00376 ? 39  ASP A C   1 
ATOM   308  O O   . ASP A 1 39  ? -11.06687 -38.83827 -2.92374  1.000 31.29762 ? 39  ASP A O   1 
ATOM   309  C CB  . ASP A 1 39  ? -13.06898 -39.91904 -1.02012  1.000 23.04933 ? 39  ASP A CB  1 
ATOM   310  C CG  . ASP A 1 39  ? -13.51140 -41.28328 -0.54246  1.000 23.64084 ? 39  ASP A CG  1 
ATOM   311  O OD1 . ASP A 1 39  ? -12.66654 -42.05908 -0.04142  1.000 27.54062 ? 39  ASP A OD1 1 
ATOM   312  O OD2 . ASP A 1 39  ? -14.71830 -41.58245 -0.66405  1.000 28.44418 ? 39  ASP A OD2 1 
ATOM   313  N N   . ALA A 1 40  ? -10.80045 -37.38261 -1.23325  1.000 24.42336 ? 40  ALA A N   1 
ATOM   314  C CA  . ALA A 1 40  ? -10.34510 -36.34172 -2.13591  1.000 21.64279 ? 40  ALA A CA  1 
ATOM   315  C C   . ALA A 1 40  ? -8.93404  -36.65768 -2.63065  1.000 27.60331 ? 40  ALA A C   1 
ATOM   316  O O   . ALA A 1 40  ? -8.20005  -37.46714 -2.04830  1.000 25.56426 ? 40  ALA A O   1 
ATOM   317  C CB  . ALA A 1 40  ? -10.38998 -34.97736 -1.45267  1.000 22.74641 ? 40  ALA A CB  1 
ATOM   318  N N   . ALA A 1 41  ? -8.55966  -36.01488 -3.73415  1.000 26.55198 ? 41  ALA A N   1 
ATOM   319  C CA  . ALA A 1 41  ? -7.30185  -36.37144 -4.38590  1.000 29.60422 ? 41  ALA A CA  1 
ATOM   320  C C   . ALA A 1 41  ? -6.10038  -35.77579 -3.65792  1.000 21.65520 ? 41  ALA A C   1 
ATOM   321  O O   . ALA A 1 41  ? -5.07905  -36.45136 -3.47994  1.000 27.67459 ? 41  ALA A O   1 
ATOM   322  C CB  . ALA A 1 41  ? -7.34171  -35.92206 -5.84877  1.000 25.96236 ? 41  ALA A CB  1 
ATOM   323  N N   . SER A 1 42  ? -6.22376  -34.52584 -3.20126  1.000 24.17719 ? 42  SER A N   1 
ATOM   324  C CA  . SER A 1 42  ? -5.10217  -33.81131 -2.59571  1.000 21.88916 ? 42  SER A CA  1 
ATOM   325  C C   . SER A 1 42  ? -4.49654  -34.54398 -1.40601  1.000 23.94837 ? 42  SER A C   1 
ATOM   326  O O   . SER A 1 42  ? -3.29498  -34.41052 -1.15001  1.000 20.69648 ? 42  SER A O   1 
ATOM   327  C CB  . SER A 1 42  ? -5.56134  -32.41777 -2.16699  1.000 25.58348 ? 42  SER A CB  1 
ATOM   328  O OG  . SER A 1 42  ? -6.22913  -32.46779 -0.90705  1.000 29.47549 ? 42  SER A OG  1 
ATOM   329  N N   . GLN A 1 43  ? -5.30433  -35.28768 -0.64229  1.000 22.97794 ? 43  GLN A N   1 
ATOM   330  C CA  . GLN A 1 43  ? -4.85116  -35.90013 0.61554   1.000 20.84154 ? 43  GLN A CA  1 
ATOM   331  C C   . GLN A 1 43  ? -4.25673  -34.86495 1.57521   1.000 19.84921 ? 43  GLN A C   1 
ATOM   332  O O   . GLN A 1 43  ? -3.29519  -35.16088 2.28615   1.000 13.65275 ? 43  GLN A O   1 
ATOM   333  C CB  . GLN A 1 43  ? -3.83177  -37.01480 0.35803   1.000 26.07999 ? 43  GLN A CB  1 
ATOM   334  C CG  . GLN A 1 43  ? -4.40554  -38.20357 -0.38829  1.000 25.98797 ? 43  GLN A CG  1 
ATOM   335  C CD  . GLN A 1 43  ? -5.50821  -38.88730 0.37028   1.000 19.79534 ? 43  GLN A CD  1 
ATOM   336  O OE1 . GLN A 1 43  ? -5.24883  -39.63510 1.30850   1.000 22.47319 ? 43  GLN A OE1 1 
ATOM   337  N NE2 . GLN A 1 43  ? -6.75772  -38.63964 -0.03251  1.000 21.59938 ? 43  GLN A NE2 1 
ATOM   338  N N   . ARG A 1 44  ? -4.79101  -33.63539 1.58314   1.000 18.02858 ? 44  ARG A N   1 
ATOM   339  C CA  . ARG A 1 44  ? -4.31600  -32.59028 2.48486   1.000 17.95102 ? 44  ARG A CA  1 
ATOM   340  C C   . ARG A 1 44  ? -5.46410  -31.96190 3.25616   1.000 15.88703 ? 44  ARG A C   1 
ATOM   341  O O   . ARG A 1 44  ? -6.58190  -31.87961 2.76268   1.000 18.12151 ? 44  ARG A O   1 
ATOM   342  C CB  . ARG A 1 44  ? -3.57514  -31.49100 1.75270   1.000 19.37420 ? 44  ARG A CB  1 
ATOM   343  C CG  . ARG A 1 44  ? -2.55302  -32.07965 0.83612   1.000 20.58543 ? 44  ARG A CG  1 
ATOM   344  C CD  . ARG A 1 44  ? -1.16218  -31.88130 1.33043   1.000 19.18829 ? 44  ARG A CD  1 
ATOM   345  N NE  . ARG A 1 44  ? -0.81438  -30.53654 1.76544   1.000 20.16102 ? 44  ARG A NE  1 
ATOM   346  C CZ  . ARG A 1 44  ? 0.27034   -30.27187 2.48425   1.000 23.32511 ? 44  ARG A CZ  1 
ATOM   347  N NH1 . ARG A 1 44  ? 1.06963   -31.23826 2.91001   1.000 25.07461 ? 44  ARG A NH1 1 
ATOM   348  N NH2 . ARG A 1 44  ? 0.59407   -29.00799 2.73352   1.000 26.43910 ? 44  ARG A NH2 1 
ATOM   349  N N   . MET A 1 45  ? -5.15754  -31.50788 4.47335   1.000 16.55692 ? 45  MET A N   1 
ATOM   350  C CA  . MET A 1 45  ? -5.97791  -30.49520 5.13165   1.000 17.26309 ? 45  MET A CA  1 
ATOM   351  C C   . MET A 1 45  ? -6.07860  -29.26518 4.24837   1.000 20.15311 ? 45  MET A C   1 
ATOM   352  O O   . MET A 1 45  ? -5.06818  -28.78033 3.72558   1.000 15.97321 ? 45  MET A O   1 
ATOM   353  C CB  . MET A 1 45  ? -5.36200  -30.13031 6.48541   1.000 13.62502 ? 45  MET A CB  1 
ATOM   354  C CG  . MET A 1 45  ? -6.28131  -29.45996 7.49954   1.000 18.86182 ? 45  MET A CG  1 
ATOM   355  S SD  . MET A 1 45  ? -7.63414  -30.45041 8.14327   1.000 18.70196 ? 45  MET A SD  1 
ATOM   356  C CE  . MET A 1 45  ? -7.19880  -30.44200 9.88931   1.000 17.80243 ? 45  MET A CE  1 
ATOM   357  N N   . GLU A 1 46  ? -7.29759  -28.74035 4.09136   1.000 15.07489 ? 46  GLU A N   1 
ATOM   358  C CA  . GLU A 1 46  ? -7.47495  -27.62365 3.17732   1.000 16.14359 ? 46  GLU A CA  1 
ATOM   359  C C   . GLU A 1 46  ? -8.14589  -26.44760 3.86222   1.000 19.50333 ? 46  GLU A C   1 
ATOM   360  O O   . GLU A 1 46  ? -9.06124  -26.63679 4.66822   1.000 19.41519 ? 46  GLU A O   1 
ATOM   361  C CB  . GLU A 1 46  ? -8.30545  -28.04875 1.96734   1.000 16.51755 ? 46  GLU A CB  1 
ATOM   362  C CG  . GLU A 1 46  ? -7.56744  -29.03817 1.11166   1.000 19.78954 ? 46  GLU A CG  1 
ATOM   363  C CD  . GLU A 1 46  ? -8.42619  -29.62640 0.00926   1.000 25.99808 ? 46  GLU A CD  1 
ATOM   364  O OE1 . GLU A 1 46  ? -9.66112  -29.40092 0.01471   1.000 32.45887 ? 46  GLU A OE1 1 
ATOM   365  O OE2 . GLU A 1 46  ? -7.85705  -30.32366 -0.86121  1.000 36.67190 ? 46  GLU A OE2 1 
ATOM   366  N N   . PRO A 1 47  ? -7.73009  -25.22617 3.53755   1.000 19.61925 ? 47  PRO A N   1 
ATOM   367  C CA  . PRO A 1 47  ? -8.35945  -24.04613 4.14857   1.000 18.81312 ? 47  PRO A CA  1 
ATOM   368  C C   . PRO A 1 47  ? -9.79036  -23.89000 3.65788   1.000 20.91568 ? 47  PRO A C   1 
ATOM   369  O O   . PRO A 1 47  ? -10.10827 -24.20765 2.50691   1.000 18.96547 ? 47  PRO A O   1 
ATOM   370  C CB  . PRO A 1 47  ? -7.48588  -22.88114 3.67457   1.000 20.47443 ? 47  PRO A CB  1 
ATOM   371  C CG  . PRO A 1 47  ? -6.84996  -23.37650 2.39235   1.000 15.95392 ? 47  PRO A CG  1 
ATOM   372  C CD  . PRO A 1 47  ? -6.73535  -24.88207 2.50567   1.000 19.78832 ? 47  PRO A CD  1 
ATOM   373  N N   . ARG A 1 48  ? -10.66291 -23.42111 4.56177   1.000 21.38558 ? 48  ARG A N   1 
ATOM   374  C CA  . ARG A 1 48  ? -12.04850 -23.10534 4.23836   1.000 20.23389 ? 48  ARG A CA  1 
ATOM   375  C C   . ARG A 1 48  ? -12.45132 -21.73235 4.77828   1.000 21.30660 ? 48  ARG A C   1 
ATOM   376  O O   . ARG A 1 48  ? -13.65154 -21.43206 4.86028   1.000 18.80225 ? 48  ARG A O   1 
ATOM   377  C CB  . ARG A 1 48  ? -12.99495 -24.19275 4.76557   1.000 16.31259 ? 48  ARG A CB  1 
ATOM   378  C CG  . ARG A 1 48  ? -12.64487 -25.59618 4.27616   1.000 16.09951 ? 48  ARG A CG  1 
ATOM   379  C CD  . ARG A 1 48  ? -12.98858 -25.72050 2.81208   1.000 21.70239 ? 48  ARG A CD  1 
ATOM   380  N NE  . ARG A 1 48  ? -14.42029 -25.96434 2.66589   1.000 25.07777 ? 48  ARG A NE  1 
ATOM   381  C CZ  . ARG A 1 48  ? -15.11336 -25.76499 1.55352   1.000 28.52986 ? 48  ARG A CZ  1 
ATOM   382  N NH1 . ARG A 1 48  ? -14.55227 -25.23893 0.47368   1.000 24.00074 ? 48  ARG A NH1 1 
ATOM   383  N NH2 . ARG A 1 48  ? -16.40159 -26.10512 1.52278   1.000 23.30485 ? 48  ARG A NH2 1 
ATOM   384  N N   . ALA A 1 49  ? -11.47465 -20.89564 5.13683   1.000 20.25787 ? 49  ALA A N   1 
ATOM   385  C CA  . ALA A 1 49  ? -11.70250 -19.52945 5.58419   1.000 22.12996 ? 49  ALA A CA  1 
ATOM   386  C C   . ALA A 1 49  ? -10.55023 -18.66030 5.10068   1.000 29.27845 ? 49  ALA A C   1 
ATOM   387  O O   . ALA A 1 49  ? -9.41765  -19.14552 4.99644   1.000 29.91377 ? 49  ALA A O   1 
ATOM   388  C CB  . ALA A 1 49  ? -11.82042 -19.44766 7.11422   1.000 23.57960 ? 49  ALA A CB  1 
ATOM   389  N N   . PRO A 1 50  ? -10.79646 -17.37906 4.79813   1.000 27.57437 ? 50  PRO A N   1 
ATOM   390  C CA  . PRO A 1 50  ? -9.68774  -16.53793 4.30288   1.000 30.38903 ? 50  PRO A CA  1 
ATOM   391  C C   . PRO A 1 50  ? -8.58814  -16.31472 5.32758   1.000 28.55557 ? 50  PRO A C   1 
ATOM   392  O O   . PRO A 1 50  ? -7.40763  -16.25073 4.96502   1.000 34.69117 ? 50  PRO A O   1 
ATOM   393  C CB  . PRO A 1 50  ? -10.39085 -15.22322 3.93532   1.000 33.16958 ? 50  PRO A CB  1 
ATOM   394  C CG  . PRO A 1 50  ? -11.82146 -15.60034 3.71868   1.000 31.72887 ? 50  PRO A CG  1 
ATOM   395  C CD  . PRO A 1 50  ? -12.08028 -16.65941 4.75788   1.000 29.74102 ? 50  PRO A CD  1 
ATOM   396  N N   . TRP A 1 51  ? -8.93826  -16.19845 6.60632   1.000 28.49032 ? 51  TRP A N   1 
ATOM   397  C CA  . TRP A 1 51  ? -7.96286  -15.84241 7.62360   1.000 29.66228 ? 51  TRP A CA  1 
ATOM   398  C C   . TRP A 1 51  ? -7.04957  -16.99508 8.02456   1.000 27.81016 ? 51  TRP A C   1 
ATOM   399  O O   . TRP A 1 51  ? -6.01490  -16.73985 8.64416   1.000 31.79210 ? 51  TRP A O   1 
ATOM   400  C CB  . TRP A 1 51  ? -8.66778  -15.28430 8.86123   1.000 26.22615 ? 51  TRP A CB  1 
ATOM   401  C CG  . TRP A 1 51  ? -9.84406  -16.07445 9.28781   1.000 29.83522 ? 51  TRP A CG  1 
ATOM   402  C CD1 . TRP A 1 51  ? -11.14679 -15.85476 8.95216   1.000 28.63607 ? 51  TRP A CD1 1 
ATOM   403  C CD2 . TRP A 1 51  ? -9.83547  -17.21911 10.14107  1.000 28.51156 ? 51  TRP A CD2 1 
ATOM   404  N NE1 . TRP A 1 51  ? -11.95412 -16.79969 9.54470   1.000 29.39803 ? 51  TRP A NE1 1 
ATOM   405  C CE2 . TRP A 1 51  ? -11.17229 -17.64415 10.28674  1.000 24.61091 ? 51  TRP A CE2 1 
ATOM   406  C CE3 . TRP A 1 51  ? -8.82875  -17.92387 10.80612  1.000 24.83956 ? 51  TRP A CE3 1 
ATOM   407  C CZ2 . TRP A 1 51  ? -11.52183 -18.74540 11.05982  1.000 21.75559 ? 51  TRP A CZ2 1 
ATOM   408  C CZ3 . TRP A 1 51  ? -9.17658  -19.01010 11.57138  1.000 18.73354 ? 51  TRP A CZ3 1 
ATOM   409  C CH2 . TRP A 1 51  ? -10.51551 -19.41444 11.69565  1.000 21.73020 ? 51  TRP A CH2 1 
ATOM   410  N N   . ILE A 1 52  ? -7.37659  -18.24430 7.67705   1.000 27.32861 ? 52  ILE A N   1 
ATOM   411  C CA  . ILE A 1 52  ? -6.44541  -19.35277 7.91792   1.000 28.11530 ? 52  ILE A CA  1 
ATOM   412  C C   . ILE A 1 52  ? -5.42939  -19.52117 6.79370   1.000 26.67402 ? 52  ILE A C   1 
ATOM   413  O O   . ILE A 1 52  ? -4.44014  -20.25576 6.96619   1.000 23.47683 ? 52  ILE A O   1 
ATOM   414  C CB  . ILE A 1 52  ? -7.18401  -20.69310 8.11614   1.000 20.24155 ? 52  ILE A CB  1 
ATOM   415  C CG1 . ILE A 1 52  ? -6.33588  -21.71257 8.88837   1.000 19.14139 ? 52  ILE A CG1 1 
ATOM   416  C CG2 . ILE A 1 52  ? -7.61133  -21.26380 6.80112   1.000 22.72254 ? 52  ILE A CG2 1 
ATOM   417  C CD1 . ILE A 1 52  ? -5.95505  -21.30475 10.28957  1.000 20.18549 ? 52  ILE A CD1 1 
ATOM   418  N N   . GLU A 1 53  ? -5.64097  -18.88264 5.64126   1.000 28.19036 ? 53  GLU A N   1 
ATOM   419  C CA  . GLU A 1 53  ? -4.66068  -18.99097 4.56526   1.000 31.80383 ? 53  GLU A CA  1 
ATOM   420  C C   . GLU A 1 53  ? -3.35632  -18.28429 4.89616   1.000 33.55587 ? 53  GLU A C   1 
ATOM   421  O O   . GLU A 1 53  ? -2.33680  -18.58731 4.27548   1.000 33.92225 ? 53  GLU A O   1 
ATOM   422  C CB  . GLU A 1 53  ? -5.23109  -18.44082 3.26168   1.000 36.35299 ? 53  GLU A CB  1 
ATOM   423  C CG  . GLU A 1 53  ? -6.31305  -19.31841 2.66421   1.000 30.58786 ? 53  GLU A CG  1 
ATOM   424  C CD  . GLU A 1 53  ? -7.15993  -18.57337 1.66733   1.000 38.42628 ? 53  GLU A CD  1 
ATOM   425  O OE1 . GLU A 1 53  ? -6.85004  -17.39500 1.38400   1.000 46.18903 ? 53  GLU A OE1 1 
ATOM   426  O OE2 . GLU A 1 53  ? -8.14576  -19.15687 1.17771   1.000 41.60712 ? 53  GLU A OE2 1 
ATOM   427  N N   . GLN A 1 54  ? -3.36876  -17.35310 5.85558   1.000 36.01890 ? 54  GLN A N   1 
ATOM   428  C CA  . GLN A 1 54  ? -2.12626  -16.77191 6.35139   1.000 36.25208 ? 54  GLN A CA  1 
ATOM   429  C C   . GLN A 1 54  ? -1.15422  -17.83991 6.81053   1.000 35.66982 ? 54  GLN A C   1 
ATOM   430  O O   . GLN A 1 54  ? 0.06267   -17.64037 6.74765   1.000 44.44816 ? 54  GLN A O   1 
ATOM   431  C CB  . GLN A 1 54  ? -2.39155  -15.85594 7.54252   1.000 37.52074 ? 54  GLN A CB  1 
ATOM   432  C CG  . GLN A 1 54  ? -3.62216  -15.00117 7.47874   1.000 42.42181 ? 54  GLN A CG  1 
ATOM   433  C CD  . GLN A 1 54  ? -3.70284  -14.10324 8.68582   1.000 39.33212 ? 54  GLN A CD  1 
ATOM   434  O OE1 . GLN A 1 54  ? -2.70378  -13.90735 9.38435   1.000 42.82854 ? 54  GLN A OE1 1 
ATOM   435  N NE2 . GLN A 1 54  ? -4.88793  -13.56149 8.95447   1.000 38.17976 ? 54  GLN A NE2 1 
ATOM   436  N N   . GLU A 1 55  ? -1.67062  -18.95225 7.33037   1.000 32.65491 ? 55  GLU A N   1 
ATOM   437  C CA  . GLU A 1 55  ? -0.81389  -19.97294 7.91385   1.000 33.71768 ? 55  GLU A CA  1 
ATOM   438  C C   . GLU A 1 55  ? 0.15897   -20.50225 6.86860   1.000 30.30157 ? 55  GLU A C   1 
ATOM   439  O O   . GLU A 1 55  ? -0.21154  -20.72762 5.71207   1.000 33.81370 ? 55  GLU A O   1 
ATOM   440  C CB  . GLU A 1 55  ? -1.66775  -21.10717 8.48117   1.000 28.87136 ? 55  GLU A CB  1 
ATOM   441  C CG  . GLU A 1 55  ? -2.58762  -20.67032 9.61444   1.000 24.90155 ? 55  GLU A CG  1 
ATOM   442  C CD  . GLU A 1 55  ? -1.81877  -20.26327 10.84850  1.000 33.38067 ? 55  GLU A CD  1 
ATOM   443  O OE1 . GLU A 1 55  ? -0.62826  -20.62058 10.90996  1.000 31.38971 ? 55  GLU A OE1 1 
ATOM   444  O OE2 . GLU A 1 55  ? -2.39786  -19.60495 11.74842  1.000 31.06482 ? 55  GLU A OE2 1 
ATOM   445  N N   . GLY A 1 56  ? 1.41944   -20.68716 7.28351   1.000 36.43923 ? 56  GLY A N   1 
ATOM   446  C CA  . GLY A 1 56  ? 2.47288   -21.05941 6.37027   1.000 28.62791 ? 56  GLY A CA  1 
ATOM   447  C C   . GLY A 1 56  ? 2.50145   -22.54984 6.07746   1.000 31.72464 ? 56  GLY A C   1 
ATOM   448  O O   . GLY A 1 56  ? 1.69807   -23.34309 6.58571   1.000 26.61034 ? 56  GLY A O   1 
ATOM   449  N N   . PRO A 1 57  ? 3.47119   -22.94948 5.24795   1.000 25.31723 ? 57  PRO A N   1 
ATOM   450  C CA  . PRO A 1 57  ? 3.49527   -24.34045 4.76298   1.000 27.54130 ? 57  PRO A CA  1 
ATOM   451  C C   . PRO A 1 57  ? 3.75049   -25.36303 5.85766   1.000 26.36554 ? 57  PRO A C   1 
ATOM   452  O O   . PRO A 1 57  ? 3.28925   -26.50627 5.74461   1.000 26.83624 ? 57  PRO A O   1 
ATOM   453  C CB  . PRO A 1 57  ? 4.63755   -24.34164 3.73273   1.000 28.73733 ? 57  PRO A CB  1 
ATOM   454  C CG  . PRO A 1 57  ? 5.45507   -23.12172 4.05513   1.000 28.30283 ? 57  PRO A CG  1 
ATOM   455  C CD  . PRO A 1 57  ? 4.51873   -22.11582 4.63642   1.000 28.77484 ? 57  PRO A CD  1 
ATOM   456  N N   . GLU A 1 58  ? 4.49135   -25.00628 6.90290   1.000 22.76290 ? 58  GLU A N   1 
ATOM   457  C CA  . GLU A 1 58  ? 4.71085   -25.95336 7.99434   1.000 26.67332 ? 58  GLU A CA  1 
ATOM   458  C C   . GLU A 1 58  ? 3.40528   -26.28606 8.72464   1.000 24.56920 ? 58  GLU A C   1 
ATOM   459  O O   . GLU A 1 58  ? 3.19315   -27.43871 9.12715   1.000 22.94958 ? 58  GLU A O   1 
ATOM   460  C CB  . GLU A 1 58  ? 5.75721   -25.38498 8.94963   1.000 26.99704 ? 58  GLU A CB  1 
ATOM   461  C CG  . GLU A 1 58  ? 5.54642   -23.89380 9.24465   1.000 34.67837 ? 58  GLU A CG  1 
ATOM   462  C CD  . GLU A 1 58  ? 6.24663   -22.94438 8.23730   1.000 40.96638 ? 58  GLU A CD  1 
ATOM   463  O OE1 . GLU A 1 58  ? 6.01909   -21.70454 8.30739   1.000 40.30759 ? 58  GLU A OE1 1 
ATOM   464  O OE2 . GLU A 1 58  ? 7.01819   -23.43399 7.37579   1.000 43.83328 ? 58  GLU A OE2 1 
ATOM   465  N N   . TYR A 1 59  ? 2.51930   -25.29786 8.89139   1.000 24.13638 ? 59  TYR A N   1 
ATOM   466  C CA  . TYR A 1 59  ? 1.18675   -25.55527 9.45214   1.000 18.37906 ? 59  TYR A CA  1 
ATOM   467  C C   . TYR A 1 59  ? 0.44098   -26.61193 8.64461   1.000 18.12214 ? 59  TYR A C   1 
ATOM   468  O O   . TYR A 1 59  ? -0.05030  -27.60343 9.19697   1.000 19.15561 ? 59  TYR A O   1 
ATOM   469  C CB  . TYR A 1 59  ? 0.39310   -24.25144 9.49873   1.000 20.45627 ? 59  TYR A CB  1 
ATOM   470  C CG  . TYR A 1 59  ? -1.04579  -24.39205 9.99546   1.000 22.27475 ? 59  TYR A CG  1 
ATOM   471  C CD1 . TYR A 1 59  ? -1.33975  -24.38095 11.35728  1.000 21.70161 ? 59  TYR A CD1 1 
ATOM   472  C CD2 . TYR A 1 59  ? -2.10192  -24.53093 9.09805   1.000 22.38542 ? 59  TYR A CD2 1 
ATOM   473  C CE1 . TYR A 1 59  ? -2.67380  -24.51302 11.81982  1.000 20.53895 ? 59  TYR A CE1 1 
ATOM   474  C CE2 . TYR A 1 59  ? -3.42235  -24.64489 9.53469   1.000 22.72148 ? 59  TYR A CE2 1 
ATOM   475  C CZ  . TYR A 1 59  ? -3.69961  -24.64405 10.89261  1.000 23.60321 ? 59  TYR A CZ  1 
ATOM   476  O OH  . TYR A 1 59  ? -5.00957  -24.75904 11.30660  1.000 23.89687 ? 59  TYR A OH  1 
ATOM   477  N N   . TRP A 1 60  ? 0.34986   -26.41682 7.32493   1.000 21.43554 ? 60  TRP A N   1 
ATOM   478  C CA  . TRP A 1 60  ? -0.44841  -27.30899 6.49068   1.000 16.05278 ? 60  TRP A CA  1 
ATOM   479  C C   . TRP A 1 60  ? 0.14096   -28.70822 6.45049   1.000 19.38854 ? 60  TRP A C   1 
ATOM   480  O O   . TRP A 1 60  ? -0.60122  -29.69440 6.44244   1.000 16.32626 ? 60  TRP A O   1 
ATOM   481  C CB  . TRP A 1 60  ? -0.58312  -26.71372 5.08771   1.000 15.28935 ? 60  TRP A CB  1 
ATOM   482  C CG  . TRP A 1 60  ? -1.36238  -25.44340 5.15151   1.000 19.73793 ? 60  TRP A CG  1 
ATOM   483  C CD1 . TRP A 1 60  ? -0.89356  -24.17534 5.00032   1.000 18.73438 ? 60  TRP A CD1 1 
ATOM   484  C CD2 . TRP A 1 60  ? -2.75766  -25.32349 5.46603   1.000 18.21846 ? 60  TRP A CD2 1 
ATOM   485  N NE1 . TRP A 1 60  ? -1.90884  -23.27029 5.17014   1.000 21.49324 ? 60  TRP A NE1 1 
ATOM   486  C CE2 . TRP A 1 60  ? -3.06777  -23.95048 5.46309   1.000 18.80890 ? 60  TRP A CE2 1 
ATOM   487  C CE3 . TRP A 1 60  ? -3.77245  -26.24702 5.72931   1.000 18.44393 ? 60  TRP A CE3 1 
ATOM   488  C CZ2 . TRP A 1 60  ? -4.36224  -23.47325 5.70720   1.000 21.58323 ? 60  TRP A CZ2 1 
ATOM   489  C CZ3 . TRP A 1 60  ? -5.06067  -25.77032 5.99408   1.000 18.12455 ? 60  TRP A CZ3 1 
ATOM   490  C CH2 . TRP A 1 60  ? -5.34043  -24.39659 5.98120   1.000 17.47643 ? 60  TRP A CH2 1 
ATOM   491  N N   . ASP A 1 61  ? 1.47575   -28.81775 6.40994   1.000 16.15395 ? 61  ASP A N   1 
ATOM   492  C CA  . ASP A 1 61  ? 2.10714   -30.13463 6.50311   1.000 17.25169 ? 61  ASP A CA  1 
ATOM   493  C C   . ASP A 1 61  ? 1.76652   -30.80235 7.83328   1.000 15.99337 ? 61  ASP A C   1 
ATOM   494  O O   . ASP A 1 61  ? 1.36096   -31.96985 7.87581   1.000 16.57086 ? 61  ASP A O   1 
ATOM   495  C CB  . ASP A 1 61  ? 3.62745   -30.01519 6.36194   1.000 19.52327 ? 61  ASP A CB  1 
ATOM   496  C CG  . ASP A 1 61  ? 4.07612   -29.69147 4.93956   1.000 23.78356 ? 61  ASP A CG  1 
ATOM   497  O OD1 . ASP A 1 61  ? 3.25512   -29.77051 3.99924   1.000 19.69289 ? 61  ASP A OD1 1 
ATOM   498  O OD2 . ASP A 1 61  ? 5.28028   -29.39411 4.76194   1.000 26.86693 ? 61  ASP A OD2 1 
ATOM   499  N N   . GLU A 1 62  ? 1.93765   -30.07127 8.93635   1.000 14.39563 ? 62  GLU A N   1 
ATOM   500  C CA  . GLU A 1 62  ? 1.72626   -30.66064 10.25190  1.000 19.50051 ? 62  GLU A CA  1 
ATOM   501  C C   . GLU A 1 62  ? 0.25393   -31.01912 10.45860  1.000 18.94369 ? 62  GLU A C   1 
ATOM   502  O O   . GLU A 1 62  ? -0.07251  -32.12965 10.89704  1.000 18.34248 ? 62  GLU A O   1 
ATOM   503  C CB  . GLU A 1 62  ? 2.22691   -29.69176 11.32532  1.000 19.00785 ? 62  GLU A CB  1 
ATOM   504  C CG  . GLU A 1 62  ? 1.76889   -30.01752 12.73374  1.000 27.52040 ? 62  GLU A CG  1 
ATOM   505  C CD  . GLU A 1 62  ? 2.60209   -31.09288 13.41164  1.000 31.94004 ? 62  GLU A CD  1 
ATOM   506  O OE1 . GLU A 1 62  ? 3.51077   -31.64459 12.74585  1.000 35.53893 ? 62  GLU A OE1 1 
ATOM   507  O OE2 . GLU A 1 62  ? 2.35400   -31.36707 14.62530  1.000 31.42774 ? 62  GLU A OE2 1 
ATOM   508  N N   . GLU A 1 63  ? -0.65625  -30.10480 10.12102  1.000 16.52890 ? 63  GLU A N   1 
ATOM   509  C CA  . GLU A 1 63  ? -2.06970  -30.42587 10.32326  1.000 16.11848 ? 63  GLU A CA  1 
ATOM   510  C C   . GLU A 1 63  ? -2.49096  -31.58999 9.43134   1.000 16.83298 ? 63  GLU A C   1 
ATOM   511  O O   . GLU A 1 63  ? -3.29540  -32.42920 9.84527   1.000 11.90318 ? 63  GLU A O   1 
ATOM   512  C CB  . GLU A 1 63  ? -2.95496  -29.20206 10.07405  1.000 18.81434 ? 63  GLU A CB  1 
ATOM   513  C CG  . GLU A 1 63  ? -2.66998  -28.01143 10.98887  1.000 17.38137 ? 63  GLU A CG  1 
ATOM   514  C CD  . GLU A 1 63  ? -2.95375  -28.29601 12.47992  1.000 23.76560 ? 63  GLU A CD  1 
ATOM   515  O OE1 . GLU A 1 63  ? -4.08455  -28.76526 12.80955  1.000 17.35086 ? 63  GLU A OE1 1 
ATOM   516  O OE2 . GLU A 1 63  ? -2.03494  -28.05078 13.31844  1.000 19.16130 ? 63  GLU A OE2 1 
ATOM   517  N N   . THR A 1 64  ? -1.93267  -31.67866 8.21841   1.000 15.21999 ? 64  THR A N   1 
ATOM   518  C CA  . THR A 1 64  ? -2.20571  -32.83633 7.36930   1.000 18.03060 ? 64  THR A CA  1 
ATOM   519  C C   . THR A 1 64  ? -1.69921  -34.11787 8.01112   1.000 14.72966 ? 64  THR A C   1 
ATOM   520  O O   . THR A 1 64  ? -2.38866  -35.14005 7.99122   1.000 17.67642 ? 64  THR A O   1 
ATOM   521  C CB  . THR A 1 64  ? -1.56562  -32.66559 5.98906   1.000 15.56085 ? 64  THR A CB  1 
ATOM   522  O OG1 . THR A 1 64  ? -2.08103  -31.47861 5.36726   1.000 14.77978 ? 64  THR A OG1 1 
ATOM   523  C CG2 . THR A 1 64  ? -1.84315  -33.90219 5.11429   1.000 17.53744 ? 64  THR A CG2 1 
ATOM   524  N N   . GLY A 1 65  ? -0.47034  -34.09723 8.54210   1.000 17.78419 ? 65  GLY A N   1 
ATOM   525  C CA  . GLY A 1 65  ? 0.01734   -35.25846 9.26936   1.000 15.50501 ? 65  GLY A CA  1 
ATOM   526  C C   . GLY A 1 65  ? -0.95043  -35.69051 10.36227  1.000 19.10925 ? 65  GLY A C   1 
ATOM   527  O O   . GLY A 1 65  ? -1.29688  -36.86210 10.47851  1.000 15.04912 ? 65  GLY A O   1 
ATOM   528  N N   . LYS A 1 66  ? -1.41987  -34.73803 11.16610  1.000 17.78006 ? 66  LYS A N   1 
ATOM   529  C CA  . LYS A 1 66  ? -2.26875  -35.10558 12.30347  1.000 15.19690 ? 66  LYS A CA  1 
ATOM   530  C C   . LYS A 1 66  ? -3.61356  -35.68241 11.85417  1.000 15.97015 ? 66  LYS A C   1 
ATOM   531  O O   . LYS A 1 66  ? -4.11870  -36.62540 12.46850  1.000 15.47912 ? 66  LYS A O   1 
ATOM   532  C CB  . LYS A 1 66  ? -2.46211  -33.89018 13.21517  1.000 18.03396 ? 66  LYS A CB  1 
ATOM   533  C CG  . LYS A 1 66  ? -1.22425  -33.52058 14.03172  1.000 17.84277 ? 66  LYS A CG  1 
ATOM   534  C CD  . LYS A 1 66  ? -1.50689  -32.42189 15.05870  1.000 23.45527 ? 66  LYS A CD  1 
ATOM   535  C CE  . LYS A 1 66  ? -1.87522  -31.09097 14.40728  1.000 21.36473 ? 66  LYS A CE  1 
ATOM   536  N NZ  . LYS A 1 66  ? -1.48971  -29.90648 15.25519  1.000 19.44635 ? 66  LYS A NZ  1 
ATOM   537  N N   . VAL A 1 67  ? -4.22388  -35.14258 10.79526  1.000 15.68797 ? 67  VAL A N   1 
ATOM   538  C CA  . VAL A 1 67  ? -5.57580  -35.62423 10.47545  1.000 14.48275 ? 67  VAL A CA  1 
ATOM   539  C C   . VAL A 1 67  ? -5.51865  -36.98637 9.78353   1.000 17.25434 ? 67  VAL A C   1 
ATOM   540  O O   . VAL A 1 67  ? -6.39254  -37.84014 10.01325  1.000 14.27186 ? 67  VAL A O   1 
ATOM   541  C CB  . VAL A 1 67  ? -6.35336  -34.57320 9.65554   1.000 14.51246 ? 67  VAL A CB  1 
ATOM   542  C CG1 . VAL A 1 67  ? -5.84354  -34.46860 8.20279   1.000 12.95582 ? 67  VAL A CG1 1 
ATOM   543  C CG2 . VAL A 1 67  ? -7.86999  -34.81936 9.71651   1.000 15.40944 ? 67  VAL A CG2 1 
ATOM   544  N N   . LYS A 1 68  ? -4.47550  -37.23859 8.97384   1.000 15.55748 ? 68  LYS A N   1 
ATOM   545  C CA  . LYS A 1 68  ? -4.29722  -38.56040 8.37580   1.000 15.63070 ? 68  LYS A CA  1 
ATOM   546  C C   . LYS A 1 68  ? -4.05182  -39.60278 9.45669   1.000 16.32001 ? 68  LYS A C   1 
ATOM   547  O O   . LYS A 1 68  ? -4.56364  -40.72425 9.37771   1.000 21.02285 ? 68  LYS A O   1 
ATOM   548  C CB  . LYS A 1 68  ? -3.13643  -38.53256 7.36295   1.000 16.38486 ? 68  LYS A CB  1 
ATOM   549  C CG  . LYS A 1 68  ? -3.47050  -37.73304 6.08475   1.000 15.15519 ? 68  LYS A CG  1 
ATOM   550  C CD  . LYS A 1 68  ? -2.28694  -37.57916 5.10589   1.000 25.36357 ? 68  LYS A CD  1 
ATOM   551  C CE  . LYS A 1 68  ? -1.42027  -38.81544 4.98656   1.000 19.42429 ? 68  LYS A CE  1 
ATOM   552  N NZ  . LYS A 1 68  ? -0.12410  -38.51665 4.27296   1.000 33.60028 ? 68  LYS A NZ  1 
ATOM   553  N N   . ALA A 1 69  ? -3.28846  -39.24680 10.49090  1.000 15.76058 ? 69  ALA A N   1 
ATOM   554  C CA  . ALA A 1 69  ? -3.08763  -40.17778 11.59546  1.000 18.65379 ? 69  ALA A CA  1 
ATOM   555  C C   . ALA A 1 69  ? -4.42116  -40.52395 12.24796  1.000 15.73986 ? 69  ALA A C   1 
ATOM   556  O O   . ALA A 1 69  ? -4.72383  -41.69761 12.49580  1.000 15.87535 ? 69  ALA A O   1 
ATOM   557  C CB  . ALA A 1 69  ? -2.12317  -39.58339 12.61939  1.000 16.90461 ? 69  ALA A CB  1 
ATOM   558  N N   . HIS A 1 70  ? -5.24225  -39.50922 12.51398  1.000 16.03588 ? 70  HIS A N   1 
ATOM   559  C CA  . HIS A 1 70  ? -6.56880  -39.76334 13.07003  1.000 17.75196 ? 70  HIS A CA  1 
ATOM   560  C C   . HIS A 1 70  ? -7.36495  -40.68283 12.15448  1.000 14.06426 ? 70  HIS A C   1 
ATOM   561  O O   . HIS A 1 70  ? -8.02781  -41.61415 12.62817  1.000 15.71501 ? 70  HIS A O   1 
ATOM   562  C CB  . HIS A 1 70  ? -7.30223  -38.44094 13.28364  1.000 15.75603 ? 70  HIS A CB  1 
ATOM   563  C CG  . HIS A 1 70  ? -8.62308  -38.56715 13.99273  1.000 15.87817 ? 70  HIS A CG  1 
ATOM   564  N ND1 . HIS A 1 70  ? -9.53305  -37.52953 14.04205  1.000 18.14441 ? 70  HIS A ND1 1 
ATOM   565  C CD2 . HIS A 1 70  ? -9.17243  -39.58009 14.70766  1.000 17.26404 ? 70  HIS A CD2 1 
ATOM   566  C CE1 . HIS A 1 70  ? -10.58704 -37.89849 14.75209  1.000 14.44371 ? 70  HIS A CE1 1 
ATOM   567  N NE2 . HIS A 1 70  ? -10.40585 -39.14550 15.14780  1.000 16.62522 ? 70  HIS A NE2 1 
ATOM   568  N N   . SER A 1 71  ? -7.27178  -40.47015 10.82924  1.000 15.03129 ? 71  SER A N   1 
ATOM   569  C CA  . SER A 1 71  ? -8.03788  -41.30139 9.90749   1.000 15.96875 ? 71  SER A CA  1 
ATOM   570  C C   . SER A 1 71  ? -7.65278  -42.76437 10.03854  1.000 18.57176 ? 71  SER A C   1 
ATOM   571  O O   . SER A 1 71  ? -8.52610  -43.63232 10.05190  1.000 20.00246 ? 71  SER A O   1 
ATOM   572  C CB  . SER A 1 71  ? -7.86918  -40.83205 8.45916   1.000 17.82695 ? 71  SER A CB  1 
ATOM   573  O OG  . SER A 1 71  ? -6.61417  -41.24837 7.93113   1.000 22.30295 ? 71  SER A OG  1 
ATOM   574  N N   . GLN A 1 72  ? -6.35875  -43.06517 10.17873  1.000 15.62589 ? 72  GLN A N   1 
ATOM   575  C CA  . GLN A 1 72  ? -5.96306  -44.46286 10.36054  1.000 14.42342 ? 72  GLN A CA  1 
ATOM   576  C C   . GLN A 1 72  ? -6.36901  -44.99344 11.73336  1.000 17.48320 ? 72  GLN A C   1 
ATOM   577  O O   . GLN A 1 72  ? -6.76615  -46.15731 11.86470  1.000 17.69164 ? 72  GLN A O   1 
ATOM   578  C CB  . GLN A 1 72  ? -4.45148  -44.61488 10.16507  1.000 17.90351 ? 72  GLN A CB  1 
ATOM   579  C CG  . GLN A 1 72  ? -4.00968  -44.12019 8.80826   1.000 29.25320 ? 72  GLN A CG  1 
ATOM   580  C CD  . GLN A 1 72  ? -4.58171  -44.98997 7.69667   1.000 38.34802 ? 72  GLN A CD  1 
ATOM   581  O OE1 . GLN A 1 72  ? -4.45498  -46.21755 7.72925   1.000 38.11737 ? 72  GLN A OE1 1 
ATOM   582  N NE2 . GLN A 1 72  ? -5.24988  -44.36055 6.72947   1.000 40.61976 ? 72  GLN A NE2 1 
ATOM   583  N N   . THR A 1 73  ? -6.25062  -44.17162 12.77395  1.000 15.42043 ? 73  THR A N   1 
ATOM   584  C CA  . THR A 1 73  ? -6.68875  -44.60634 14.09726  1.000 18.05997 ? 73  THR A CA  1 
ATOM   585  C C   . THR A 1 73  ? -8.16665  -44.99456 14.08866  1.000 18.59649 ? 73  THR A C   1 
ATOM   586  O O   . THR A 1 73  ? -8.54724  -46.06303 14.58265  1.000 18.05343 ? 73  THR A O   1 
ATOM   587  C CB  . THR A 1 73  ? -6.40455  -43.50160 15.11662  1.000 18.77144 ? 73  THR A CB  1 
ATOM   588  O OG1 . THR A 1 73  ? -4.98848  -43.30018 15.17982  1.000 17.49451 ? 73  THR A OG1 1 
ATOM   589  C CG2 . THR A 1 73  ? -6.92658  -43.87572 16.49098  1.000 16.41763 ? 73  THR A CG2 1 
ATOM   590  N N   . ASP A 1 74  ? -9.01508  -44.16238 13.49332  1.000 19.05239 ? 74  ASP A N   1 
ATOM   591  C CA  . ASP A 1 74  ? -10.43277 -44.45676 13.59477  1.000 17.17232 ? 74  ASP A CA  1 
ATOM   592  C C   . ASP A 1 74  ? -10.86887 -45.58407 12.64806  1.000 20.31562 ? 74  ASP A C   1 
ATOM   593  O O   . ASP A 1 74  ? -11.88458 -46.23359 12.92743  1.000 19.46425 ? 74  ASP A O   1 
ATOM   594  C CB  . ASP A 1 74  ? -11.24935 -43.17022 13.39755  1.000 24.06257 ? 74  ASP A CB  1 
ATOM   595  C CG  . ASP A 1 74  ? -11.46924 -42.42545 14.74544  1.000 24.63171 ? 74  ASP A CG  1 
ATOM   596  O OD1 . ASP A 1 74  ? -10.90739 -42.93010 15.75169  1.000 18.66204 ? 74  ASP A OD1 1 
ATOM   597  O OD2 . ASP A 1 74  ? -12.23152 -41.40724 14.83119  1.000 16.93310 ? 74  ASP A OD2 1 
ATOM   598  N N   . ARG A 1 75  ? -10.11808 -45.86251 11.56165  1.000 16.68654 ? 75  ARG A N   1 
ATOM   599  C CA  . ARG A 1 75  ? -10.36437 -47.09658 10.81005  1.000 21.87753 ? 75  ARG A CA  1 
ATOM   600  C C   . ARG A 1 75  ? -10.16759 -48.32004 11.68877  1.000 21.88024 ? 75  ARG A C   1 
ATOM   601  O O   . ARG A 1 75  ? -10.97549 -49.25285 11.64565  1.000 25.33968 ? 75  ARG A O   1 
ATOM   602  C CB  . ARG A 1 75  ? -9.46634  -47.21208 9.57400   1.000 22.32445 ? 75  ARG A CB  1 
ATOM   603  C CG  . ARG A 1 75  ? -9.31163  -45.95233 8.79979   1.000 32.57696 ? 75  ARG A CG  1 
ATOM   604  C CD  . ARG A 1 75  ? -9.76567  -46.00558 7.34560   1.000 40.22615 ? 75  ARG A CD  1 
ATOM   605  N NE  . ARG A 1 75  ? -9.33734  -44.79216 6.65286   1.000 41.24742 ? 75  ARG A NE  1 
ATOM   606  C CZ  . ARG A 1 75  ? -8.67773  -44.77420 5.50107   1.000 49.23233 ? 75  ARG A CZ  1 
ATOM   607  N NH1 . ARG A 1 75  ? -8.34786  -45.89459 4.87204   1.000 44.95736 ? 75  ARG A NH1 1 
ATOM   608  N NH2 . ARG A 1 75  ? -8.31458  -43.60383 4.98035   1.000 50.92100 ? 75  ARG A NH2 1 
ATOM   609  N N   . GLU A 1 76  ? -9.09617  -48.33943 12.48696  1.000 19.18059 ? 76  GLU A N   1 
ATOM   610  C CA  . GLU A 1 76  ? -8.93334  -49.41084 13.46237  1.000 26.26163 ? 76  GLU A CA  1 
ATOM   611  C C   . GLU A 1 76  ? -10.08161 -49.43673 14.46602  1.000 23.01753 ? 76  GLU A C   1 
ATOM   612  O O   . GLU A 1 76  ? -10.62273 -50.50479 14.77584  1.000 22.14343 ? 76  GLU A O   1 
ATOM   613  C CB  . GLU A 1 76  ? -7.60857  -49.26359 14.19660  1.000 24.10060 ? 76  GLU A CB  1 
ATOM   614  C CG  . GLU A 1 76  ? -6.59234  -50.31307 13.84174  1.000 35.51764 ? 76  GLU A CG  1 
ATOM   615  C CD  . GLU A 1 76  ? -7.22795  -51.67357 13.62913  1.000 45.09878 ? 76  GLU A CD  1 
ATOM   616  O OE1 . GLU A 1 76  ? -7.43224  -52.07322 12.45151  1.000 47.03223 ? 76  GLU A OE1 1 
ATOM   617  O OE2 . GLU A 1 76  ? -7.56555  -52.32066 14.64641  1.000 41.55312 ? 76  GLU A OE2 1 
ATOM   618  N N   . ASN A 1 77  ? -10.47322 -48.27336 14.98062  1.000 20.41504 ? 77  ASN A N   1 
ATOM   619  C CA  . ASN A 1 77  ? -11.51573 -48.25087 16.00552  1.000 21.85455 ? 77  ASN A CA  1 
ATOM   620  C C   . ASN A 1 77  ? -12.83913 -48.79547 15.47231  1.000 19.11214 ? 77  ASN A C   1 
ATOM   621  O O   . ASN A 1 77  ? -13.61085 -49.40284 16.23522  1.000 18.10198 ? 77  ASN A O   1 
ATOM   622  C CB  . ASN A 1 77  ? -11.67000 -46.83366 16.55962  1.000 16.92354 ? 77  ASN A CB  1 
ATOM   623  C CG  . ASN A 1 77  ? -10.54681 -46.46426 17.50818  1.000 18.01218 ? 77  ASN A CG  1 
ATOM   624  O OD1 . ASN A 1 77  ? -9.91545  -47.33817 18.08558  1.000 18.31746 ? 77  ASN A OD1 1 
ATOM   625  N ND2 . ASN A 1 77  ? -10.28630 -45.17598 17.66386  1.000 17.82574 ? 77  ASN A ND2 1 
ATOM   626  N N   . LEU A 1 78  ? -13.09258 -48.63561 14.16511  1.000 19.15644 ? 78  LEU A N   1 
ATOM   627  C CA  . LEU A 1 78  ? -14.29210 -49.20898 13.56666  1.000 21.52248 ? 78  LEU A CA  1 
ATOM   628  C C   . LEU A 1 78  ? -14.28201 -50.72570 13.68047  1.000 21.88131 ? 78  LEU A C   1 
ATOM   629  O O   . LEU A 1 78  ? -15.31758 -51.34734 13.94965  1.000 19.17479 ? 78  LEU A O   1 
ATOM   630  C CB  . LEU A 1 78  ? -14.41395 -48.78170 12.09980  1.000 18.42384 ? 78  LEU A CB  1 
ATOM   631  C CG  . LEU A 1 78  ? -15.12519 -47.43977 11.90193  1.000 18.49278 ? 78  LEU A CG  1 
ATOM   632  C CD1 . LEU A 1 78  ? -14.97210 -46.90166 10.48802  1.000 24.88828 ? 78  LEU A CD1 1 
ATOM   633  C CD2 . LEU A 1 78  ? -16.60126 -47.54021 12.31597  1.000 18.10154 ? 78  LEU A CD2 1 
ATOM   634  N N   . ARG A 1 79  ? -13.11594 -51.33762 13.48476  1.000 19.53727 ? 79  ARG A N   1 
ATOM   635  C CA  . ARG A 1 79  ? -13.02213 -52.79058 13.53436  1.000 23.59708 ? 79  ARG A CA  1 
ATOM   636  C C   . ARG A 1 79  ? -13.13350 -53.30244 14.96362  1.000 21.47206 ? 79  ARG A C   1 
ATOM   637  O O   . ARG A 1 79  ? -13.73379 -54.35590 15.20466  1.000 21.19546 ? 79  ARG A O   1 
ATOM   638  C CB  . ARG A 1 79  ? -11.70443 -53.23305 12.91299  1.000 21.23031 ? 79  ARG A CB  1 
ATOM   639  C CG  . ARG A 1 79  ? -11.67110 -53.17163 11.39923  1.000 27.21083 ? 79  ARG A CG  1 
ATOM   640  C CD  . ARG A 1 79  ? -10.24973 -53.36489 10.94494  1.000 34.45937 ? 79  ARG A CD  1 
ATOM   641  N NE  . ARG A 1 79  ? -9.91064  -54.78095 10.90233  1.000 42.10964 ? 79  ARG A NE  1 
ATOM   642  C CZ  . ARG A 1 79  ? -8.67131  -55.25317 10.93036  1.000 52.90521 ? 79  ARG A CZ  1 
ATOM   643  N NH1 . ARG A 1 79  ? -7.62352  -54.44390 10.98178  1.000 51.45468 ? 79  ARG A NH1 1 
ATOM   644  N NH2 . ARG A 1 79  ? -8.47808  -56.57003 10.92398  1.000 52.44771 ? 79  ARG A NH2 1 
ATOM   645  N N   . ILE A 1 80  ? -12.51978 -52.59116 15.91466  1.000 21.71239 ? 80  ILE A N   1 
ATOM   646  C CA  . ILE A 1 80  ? -12.62949 -52.95434 17.32804  1.000 21.16282 ? 80  ILE A CA  1 
ATOM   647  C C   . ILE A 1 80  ? -14.07701 -52.85735 17.78903  1.000 19.78152 ? 80  ILE A C   1 
ATOM   648  O O   . ILE A 1 80  ? -14.58786 -53.73574 18.49523  1.000 21.33895 ? 80  ILE A O   1 
ATOM   649  C CB  . ILE A 1 80  ? -11.71762 -52.05771 18.18928  1.000 18.20933 ? 80  ILE A CB  1 
ATOM   650  C CG1 . ILE A 1 80  ? -10.24222 -52.39415 17.97777  1.000 19.26972 ? 80  ILE A CG1 1 
ATOM   651  C CG2 . ILE A 1 80  ? -12.06073 -52.17949 19.68253  1.000 20.73488 ? 80  ILE A CG2 1 
ATOM   652  C CD1 . ILE A 1 80  ? -9.34332  -51.24604 18.37337  1.000 19.82421 ? 80  ILE A CD1 1 
ATOM   653  N N   . ALA A 1 81  ? -14.75383 -51.76311 17.43257  1.000 16.74436 ? 81  ALA A N   1 
ATOM   654  C CA  . ALA A 1 81  ? -16.14431 -51.63186 17.85084  1.000 19.88120 ? 81  ALA A CA  1 
ATOM   655  C C   . ALA A 1 81  ? -16.98647 -52.73874 17.24966  1.000 20.49468 ? 81  ALA A C   1 
ATOM   656  O O   . ALA A 1 81  ? -17.94392 -53.21023 17.87171  1.000 24.44210 ? 81  ALA A O   1 
ATOM   657  C CB  . ALA A 1 81  ? -16.69705 -50.26419 17.45380  1.000 16.74727 ? 81  ALA A CB  1 
ATOM   658  N N   . LEU A 1 82  ? -16.64086 -53.17454 16.04578  1.000 23.11359 ? 82  LEU A N   1 
ATOM   659  C CA  . LEU A 1 82  ? -17.36001 -54.28423 15.44343  1.000 26.59999 ? 82  LEU A CA  1 
ATOM   660  C C   . LEU A 1 82  ? -17.21181 -55.53603 16.30524  1.000 27.76863 ? 82  LEU A C   1 
ATOM   661  O O   . LEU A 1 82  ? -18.17308 -56.28325 16.51268  1.000 31.11645 ? 82  LEU A O   1 
ATOM   662  C CB  . LEU A 1 82  ? -16.82745 -54.49712 14.02697  1.000 25.52312 ? 82  LEU A CB  1 
ATOM   663  C CG  . LEU A 1 82  ? -17.70756 -55.28327 13.07570  1.000 31.53631 ? 82  LEU A CG  1 
ATOM   664  C CD1 . LEU A 1 82  ? -18.87172 -54.38397 12.68904  1.000 28.39633 ? 82  LEU A CD1 1 
ATOM   665  C CD2 . LEU A 1 82  ? -16.88394 -55.60969 11.85877  1.000 34.85882 ? 82  LEU A CD2 1 
ATOM   666  N N   . ARG A 1 83  ? -16.01868 -55.75132 16.85844  1.000 25.64328 ? 83  ARG A N   1 
ATOM   667  C CA  . ARG A 1 83  ? -15.79784 -56.89612 17.73370  1.000 27.02288 ? 83  ARG A CA  1 
ATOM   668  C C   . ARG A 1 83  ? -16.54737 -56.73664 19.05397  1.000 30.12135 ? 83  ARG A C   1 
ATOM   669  O O   . ARG A 1 83  ? -17.22409 -57.66603 19.50301  1.000 28.86556 ? 83  ARG A O   1 
ATOM   670  C CB  . ARG A 1 83  ? -14.29820 -57.08931 17.97167  1.000 32.98626 ? 83  ARG A CB  1 
ATOM   671  C CG  . ARG A 1 83  ? -13.91838 -58.48675 18.45267  1.000 40.10940 ? 83  ARG A CG  1 
ATOM   672  C CD  . ARG A 1 83  ? -12.78231 -58.45722 19.47952  1.000 46.77600 ? 83  ARG A CD  1 
ATOM   673  N NE  . ARG A 1 83  ? -11.92526 -57.28024 19.35646  1.000 51.88479 ? 83  ARG A NE  1 
ATOM   674  C CZ  . ARG A 1 83  ? -11.27175 -56.71443 20.36665  1.000 48.22095 ? 83  ARG A CZ  1 
ATOM   675  N NH1 . ARG A 1 83  ? -11.41903 -57.14048 21.61187  1.000 48.75747 ? 83  ARG A NH1 1 
ATOM   676  N NH2 . ARG A 1 83  ? -10.45506 -55.69040 20.12278  1.000 45.39085 ? 83  ARG A NH2 1 
ATOM   677  N N   . TYR A 1 84  ? -16.45407 -55.55817 19.68491  1.000 26.81195 ? 84  TYR A N   1 
ATOM   678  C CA  . TYR A 1 84  ? -17.15135 -55.33564 20.95667  1.000 27.24373 ? 84  TYR A CA  1 
ATOM   679  C C   . TYR A 1 84  ? -18.64063 -55.64406 20.86611  1.000 28.35695 ? 84  TYR A C   1 
ATOM   680  O O   . TYR A 1 84  ? -19.21779 -56.20984 21.80065  1.000 34.20181 ? 84  TYR A O   1 
ATOM   681  C CB  . TYR A 1 84  ? -16.98171 -53.89037 21.42627  1.000 29.29671 ? 84  TYR A CB  1 
ATOM   682  C CG  . TYR A 1 84  ? -15.62350 -53.56329 21.97116  1.000 26.83698 ? 84  TYR A CG  1 
ATOM   683  C CD1 . TYR A 1 84  ? -14.67416 -54.55588 22.16102  1.000 29.94395 ? 84  TYR A CD1 1 
ATOM   684  C CD2 . TYR A 1 84  ? -15.28160 -52.25295 22.28734  1.000 24.61452 ? 84  TYR A CD2 1 
ATOM   685  C CE1 . TYR A 1 84  ? -13.42404 -54.25839 22.64754  1.000 26.63577 ? 84  TYR A CE1 1 
ATOM   686  C CE2 . TYR A 1 84  ? -14.03269 -51.94744 22.78097  1.000 24.79377 ? 84  TYR A CE2 1 
ATOM   687  C CZ  . TYR A 1 84  ? -13.10716 -52.96064 22.95644  1.000 27.43123 ? 84  TYR A CZ  1 
ATOM   688  O OH  . TYR A 1 84  ? -11.85888 -52.66767 23.44683  1.000 28.88036 ? 84  TYR A OH  1 
ATOM   689  N N   . TYR A 1 85  ? -19.29622 -55.23650 19.77733  1.000 33.35027 ? 85  TYR A N   1 
ATOM   690  C CA  . TYR A 1 85  ? -20.74398 -55.41078 19.65523  1.000 27.61817 ? 85  TYR A CA  1 
ATOM   691  C C   . TYR A 1 85  ? -21.12675 -56.72400 18.99598  1.000 29.15924 ? 85  TYR A C   1 
ATOM   692  O O   . TYR A 1 85  ? -22.32109 -57.02116 18.88980  1.000 30.00833 ? 85  TYR A O   1 
ATOM   693  C CB  . TYR A 1 85  ? -21.37494 -54.25247 18.87217  1.000 23.47230 ? 85  TYR A CB  1 
ATOM   694  C CG  . TYR A 1 85  ? -21.38717 -52.94257 19.62955  1.000 28.94182 ? 85  TYR A CG  1 
ATOM   695  C CD1 . TYR A 1 85  ? -20.31128 -52.07137 19.55761  1.000 24.26777 ? 85  TYR A CD1 1 
ATOM   696  C CD2 . TYR A 1 85  ? -22.45786 -52.59304 20.44402  1.000 27.07312 ? 85  TYR A CD2 1 
ATOM   697  C CE1 . TYR A 1 85  ? -20.30131 -50.88067 20.25173  1.000 24.74033 ? 85  TYR A CE1 1 
ATOM   698  C CE2 . TYR A 1 85  ? -22.45091 -51.40117 21.14691  1.000 28.45843 ? 85  TYR A CE2 1 
ATOM   699  C CZ  . TYR A 1 85  ? -21.36509 -50.54733 21.04226  1.000 24.43493 ? 85  TYR A CZ  1 
ATOM   700  O OH  . TYR A 1 85  ? -21.33657 -49.34957 21.73362  1.000 26.06746 ? 85  TYR A OH  1 
ATOM   701  N N   . ASN A 1 86  ? -20.14312 -57.51152 18.57110  1.000 29.70961 ? 86  ASN A N   1 
ATOM   702  C CA  . ASN A 1 86  ? -20.34838 -58.74612 17.82210  1.000 30.23901 ? 86  ASN A CA  1 
ATOM   703  C C   . ASN A 1 86  ? -21.22883 -58.49723 16.59189  1.000 33.40048 ? 86  ASN A C   1 
ATOM   704  O O   . ASN A 1 86  ? -22.35863 -58.97204 16.48620  1.000 31.52334 ? 86  ASN A O   1 
ATOM   705  C CB  . ASN A 1 86  ? -20.93340 -59.82998 18.73407  1.000 33.28453 ? 86  ASN A CB  1 
ATOM   706  C CG  . ASN A 1 86  ? -20.90301 -61.20741 18.09941  1.000 35.02987 ? 86  ASN A CG  1 
ATOM   707  O OD1 . ASN A 1 86  ? -20.03714 -61.51492 17.27800  1.000 41.01937 ? 86  ASN A OD1 1 
ATOM   708  N ND2 . ASN A 1 86  ? -21.84604 -62.04974 18.48789  1.000 36.24629 ? 86  ASN A ND2 1 
ATOM   709  N N   . GLN A 1 87  ? -20.67483 -57.73273 15.64963  1.000 28.11983 ? 87  GLN A N   1 
ATOM   710  C CA  . GLN A 1 87  ? -21.37335 -57.45797 14.39991  1.000 30.97300 ? 87  GLN A CA  1 
ATOM   711  C C   . GLN A 1 87  ? -20.55983 -57.97085 13.22094  1.000 32.89897 ? 87  GLN A C   1 
ATOM   712  O O   . GLN A 1 87  ? -19.34802 -58.18302 13.31981  1.000 36.04939 ? 87  GLN A O   1 
ATOM   713  C CB  . GLN A 1 87  ? -21.69426 -55.96132 14.24905  1.000 28.50703 ? 87  GLN A CB  1 
ATOM   714  C CG  . GLN A 1 87  ? -21.89399 -55.26154 15.58735  1.000 30.76182 ? 87  GLN A CG  1 
ATOM   715  C CD  . GLN A 1 87  ? -22.22549 -53.77669 15.46591  1.000 30.43844 ? 87  GLN A CD  1 
ATOM   716  O OE1 . GLN A 1 87  ? -21.36041 -52.97815 15.11498  1.000 28.03388 ? 87  GLN A OE1 1 
ATOM   717  N NE2 . GLN A 1 87  ? -23.47051 -53.39765 15.79999  1.000 22.42057 ? 87  GLN A NE2 1 
ATOM   718  N N   . SER A 1 88  ? -21.24791 -58.21026 12.10738  1.000 35.48205 ? 88  SER A N   1 
ATOM   719  C CA  . SER A 1 88  ? -20.55320 -58.78025 10.96598  1.000 38.61021 ? 88  SER A CA  1 
ATOM   720  C C   . SER A 1 88  ? -19.82634 -57.68893 10.20365  1.000 36.14056 ? 88  SER A C   1 
ATOM   721  O O   . SER A 1 88  ? -20.19628 -56.51372 10.24589  1.000 35.35340 ? 88  SER A O   1 
ATOM   722  C CB  . SER A 1 88  ? -21.51050 -59.48157 10.00753  1.000 39.69135 ? 88  SER A CB  1 
ATOM   723  O OG  . SER A 1 88  ? -22.56120 -58.61206 9.66068   1.000 42.39956 ? 88  SER A OG  1 
ATOM   724  N N   . GLU A 1 89  ? -18.78835 -58.09938 9.47895   1.000 35.44409 ? 89  GLU A N   1 
ATOM   725  C CA  . GLU A 1 89  ? -18.12503 -57.17047 8.58519   1.000 37.83713 ? 89  GLU A CA  1 
ATOM   726  C C   . GLU A 1 89  ? -18.99661 -56.79442 7.39441   1.000 38.92730 ? 89  GLU A C   1 
ATOM   727  O O   . GLU A 1 89  ? -18.57996 -55.95524 6.58973   1.000 45.56854 ? 89  GLU A O   1 
ATOM   728  C CB  . GLU A 1 89  ? -16.78905 -57.76197 8.13412   1.000 44.68233 ? 89  GLU A CB  1 
ATOM   729  C CG  . GLU A 1 89  ? -15.76469 -57.81219 9.27208   1.000 49.43256 ? 89  GLU A CG  1 
ATOM   730  C CD  . GLU A 1 89  ? -14.78736 -58.96773 9.16028   1.000 63.41286 ? 89  GLU A CD  1 
ATOM   731  O OE1 . GLU A 1 89  ? -14.69197 -59.57254 8.07032   1.000 68.44897 ? 89  GLU A OE1 1 
ATOM   732  O OE2 . GLU A 1 89  ? -14.12329 -59.28089 10.17355  1.000 68.50931 ? 89  GLU A OE2 1 
ATOM   733  N N   . ALA A 1 90  ? -20.20995 -57.35230 7.30158   1.000 33.31486 ? 90  ALA A N   1 
ATOM   734  C CA  . ALA A 1 90  ? -21.07727 -57.09334 6.15946   1.000 38.12281 ? 90  ALA A CA  1 
ATOM   735  C C   . ALA A 1 90  ? -21.69450 -55.70186 6.20515   1.000 32.47848 ? 90  ALA A C   1 
ATOM   736  O O   . ALA A 1 90  ? -21.90891 -55.09094 5.15266   1.000 37.01597 ? 90  ALA A O   1 
ATOM   737  C CB  . ALA A 1 90  ? -22.18478 -58.14548 6.09287   1.000 40.24393 ? 90  ALA A CB  1 
ATOM   738  N N   . GLY A 1 91  ? -21.99470 -55.19008 7.39530   1.000 34.88698 ? 91  GLY A N   1 
ATOM   739  C CA  . GLY A 1 91  ? -22.74321 -53.95721 7.50487   1.000 34.68571 ? 91  GLY A CA  1 
ATOM   740  C C   . GLY A 1 91  ? -21.86728 -52.71336 7.59532   1.000 32.03507 ? 91  GLY A C   1 
ATOM   741  O O   . GLY A 1 91  ? -20.68907 -52.77109 7.92859   1.000 29.11942 ? 91  GLY A O   1 
ATOM   742  N N   . SER A 1 92  ? -22.47712 -51.57276 7.28627   1.000 29.98323 ? 92  SER A N   1 
ATOM   743  C CA  . SER A 1 92  ? -21.81129 -50.28211 7.37326   1.000 28.48069 ? 92  SER A CA  1 
ATOM   744  C C   . SER A 1 92  ? -22.11161 -49.63213 8.72241   1.000 28.82649 ? 92  SER A C   1 
ATOM   745  O O   . SER A 1 92  ? -23.24643 -49.69671 9.21129   1.000 26.08349 ? 92  SER A O   1 
ATOM   746  C CB  . SER A 1 92  ? -22.27784 -49.37554 6.23313   1.000 30.47192 ? 92  SER A CB  1 
ATOM   747  O OG  . SER A 1 92  ? -22.00918 -48.01589 6.52378   1.000 33.66440 ? 92  SER A OG  1 
ATOM   748  N N   . HIS A 1 93  ? -21.09154 -49.00130 9.31241   1.000 27.25934 ? 93  HIS A N   1 
ATOM   749  C CA  . HIS A 1 93  ? -21.18236 -48.39339 10.63550  1.000 22.10037 ? 93  HIS A CA  1 
ATOM   750  C C   . HIS A 1 93  ? -20.43463 -47.06714 10.64811  1.000 21.84083 ? 93  HIS A C   1 
ATOM   751  O O   . HIS A 1 93  ? -19.61272 -46.79290 9.77095   1.000 19.71210 ? 93  HIS A O   1 
ATOM   752  C CB  . HIS A 1 93  ? -20.60298 -49.31196 11.71493  1.000 20.67847 ? 93  HIS A CB  1 
ATOM   753  C CG  . HIS A 1 93  ? -21.38324 -50.57306 11.89550  1.000 27.26533 ? 93  HIS A CG  1 
ATOM   754  N ND1 . HIS A 1 93  ? -22.57295 -50.61617 12.58864  1.000 22.59268 ? 93  HIS A ND1 1 
ATOM   755  C CD2 . HIS A 1 93  ? -21.18166 -51.82165 11.41087  1.000 29.16797 ? 93  HIS A CD2 1 
ATOM   756  C CE1 . HIS A 1 93  ? -23.05548 -51.84697 12.54955  1.000 28.88692 ? 93  HIS A CE1 1 
ATOM   757  N NE2 . HIS A 1 93  ? -22.22889 -52.59821 11.84273  1.000 24.34747 ? 93  HIS A NE2 1 
ATOM   758  N N   . THR A 1 94  ? -20.69883 -46.26137 11.68819  1.000 17.98035 ? 94  THR A N   1 
ATOM   759  C CA  . THR A 1 94  ? -20.24431 -44.87624 11.76804  1.000 17.18060 ? 94  THR A CA  1 
ATOM   760  C C   . THR A 1 94  ? -19.60984 -44.60721 13.12687  1.000 17.23866 ? 94  THR A C   1 
ATOM   761  O O   . THR A 1 94  ? -20.20661 -44.91134 14.17135  1.000 15.61495 ? 94  THR A O   1 
ATOM   762  C CB  . THR A 1 94  ? -21.41281 -43.89468 11.55119  1.000 23.28262 ? 94  THR A CB  1 
ATOM   763  O OG1 . THR A 1 94  ? -22.03048 -44.15679 10.28729  1.000 23.02939 ? 94  THR A OG1 1 
ATOM   764  C CG2 . THR A 1 94  ? -20.91290 -42.43881 11.55677  1.000 18.54757 ? 94  THR A CG2 1 
ATOM   765  N N   . LEU A 1 95  ? -18.41987 -44.01373 13.10514  1.000 12.60123 ? 95  LEU A N   1 
ATOM   766  C CA  . LEU A 1 95  ? -17.71495 -43.55908 14.29751  1.000 13.62638 ? 95  LEU A CA  1 
ATOM   767  C C   . LEU A 1 95  ? -17.48233 -42.06332 14.13373  1.000 17.59783 ? 95  LEU A C   1 
ATOM   768  O O   . LEU A 1 95  ? -16.80262 -41.63255 13.19290  1.000 18.22944 ? 95  LEU A O   1 
ATOM   769  C CB  . LEU A 1 95  ? -16.39169 -44.31974 14.48608  1.000 15.92686 ? 95  LEU A CB  1 
ATOM   770  C CG  . LEU A 1 95  ? -15.59402 -44.03082 15.76606  1.000 17.70741 ? 95  LEU A CG  1 
ATOM   771  C CD1 . LEU A 1 95  ? -16.26101 -44.65773 16.96676  1.000 19.47348 ? 95  LEU A CD1 1 
ATOM   772  C CD2 . LEU A 1 95  ? -14.15208 -44.50523 15.66784  1.000 18.13440 ? 95  LEU A CD2 1 
ATOM   773  N N   . GLN A 1 96  ? -18.08789 -41.27072 15.00444  1.000 11.98523 ? 96  GLN A N   1 
ATOM   774  C CA  . GLN A 1 96  ? -17.89209 -39.83117 15.00052  1.000 12.18880 ? 96  GLN A CA  1 
ATOM   775  C C   . GLN A 1 96  ? -17.12449 -39.42164 16.24583  1.000 12.93132 ? 96  GLN A C   1 
ATOM   776  O O   . GLN A 1 96  ? -17.31099 -39.99876 17.32225  1.000 17.95500 ? 96  GLN A O   1 
ATOM   777  C CB  . GLN A 1 96  ? -19.21745 -39.08197 14.93479  1.000 12.96897 ? 96  GLN A CB  1 
ATOM   778  C CG  . GLN A 1 96  ? -20.08655 -39.46655 13.77002  1.000 13.02733 ? 96  GLN A CG  1 
ATOM   779  C CD  . GLN A 1 96  ? -21.52337 -39.12266 14.03146  1.000 15.76302 ? 96  GLN A CD  1 
ATOM   780  O OE1 . GLN A 1 96  ? -22.31362 -39.99635 14.36990  1.000 16.51373 ? 96  GLN A OE1 1 
ATOM   781  N NE2 . GLN A 1 96  ? -21.86816 -37.84344 13.91848  1.000 12.64656 ? 96  GLN A NE2 1 
ATOM   782  N N   . MET A 1 97  ? -16.26174 -38.42418 16.10147  1.000 15.87503 ? 97  MET A N   1 
ATOM   783  C CA  . MET A 1 97  ? -15.53607 -37.89950 17.24570  1.000 14.79511 ? 97  MET A CA  1 
ATOM   784  C C   . MET A 1 97  ? -15.64426 -36.38982 17.22617  1.000 15.01688 ? 97  MET A C   1 
ATOM   785  O O   . MET A 1 97  ? -15.75329 -35.77242 16.16207  1.000 14.77747 ? 97  MET A O   1 
ATOM   786  C CB  . MET A 1 97  ? -14.06233 -38.32749 17.23719  1.000 18.20784 ? 97  MET A CB  1 
ATOM   787  C CG  . MET A 1 97  ? -13.34533 -37.93123 18.50920  1.000 19.79915 ? 97  MET A CG  1 
ATOM   788  S SD  . MET A 1 97  ? -11.57615 -37.94137 18.29680  1.000 23.97658 ? 97  MET A SD  1 
ATOM   789  C CE  . MET A 1 97  ? -11.09830 -37.51490 19.97626  1.000 20.52455 ? 97  MET A CE  1 
ATOM   790  N N   . MET A 1 98  ? -15.65204 -35.79737 18.41363  1.000 15.82803 ? 98  MET A N   1 
ATOM   791  C CA  . MET A 1 98  ? -15.55120 -34.35785 18.51089  1.000 14.92813 ? 98  MET A CA  1 
ATOM   792  C C   . MET A 1 98  ? -14.57832 -34.05264 19.63451  1.000 15.75147 ? 98  MET A C   1 
ATOM   793  O O   . MET A 1 98  ? -14.55550 -34.74642 20.65411  1.000 16.41174 ? 98  MET A O   1 
ATOM   794  C CB  . MET A 1 98  ? -16.93630 -33.71077 18.72426  1.000 17.79928 ? 98  MET A CB  1 
ATOM   795  C CG  . MET A 1 98  ? -16.98779 -32.26476 19.19420  1.000 22.69750 ? 98  MET A CG  1 
ATOM   796  S SD  . MET A 1 98  ? -16.27831 -31.72287 20.76120  1.000 28.27738 ? 98  MET A SD  1 
ATOM   797  C CE  . MET A 1 98  ? -17.82476 -31.78009 21.71682  1.000 15.75589 ? 98  MET A CE  1 
ATOM   798  N N   . PHE A 1 99  ? -13.75572 -33.02793 19.42726  1.000 14.67504 ? 99  PHE A N   1 
ATOM   799  C CA  . PHE A 1 99  ? -12.86097 -32.56360 20.47431  1.000 14.93377 ? 99  PHE A CA  1 
ATOM   800  C C   . PHE A 1 99  ? -12.66151 -31.07021 20.27643  1.000 12.86295 ? 99  PHE A C   1 
ATOM   801  O O   . PHE A 1 99  ? -12.94960 -30.52892 19.20773  1.000 15.69909 ? 99  PHE A O   1 
ATOM   802  C CB  . PHE A 1 99  ? -11.53129 -33.34898 20.48403  1.000 16.11317 ? 99  PHE A CB  1 
ATOM   803  C CG  . PHE A 1 99  ? -10.71766 -33.19664 19.22318  1.000 15.07056 ? 99  PHE A CG  1 
ATOM   804  C CD1 . PHE A 1 99  ? -9.81145  -32.14299 19.08512  1.000 17.81844 ? 99  PHE A CD1 1 
ATOM   805  C CD2 . PHE A 1 99  ? -10.83719 -34.10684 18.20100  1.000 16.54061 ? 99  PHE A CD2 1 
ATOM   806  C CE1 . PHE A 1 99  ? -9.06212  -31.99958 17.92812  1.000 14.56675 ? 99  PHE A CE1 1 
ATOM   807  C CE2 . PHE A 1 99  ? -10.09217 -33.97400 17.05328  1.000 17.12793 ? 99  PHE A CE2 1 
ATOM   808  C CZ  . PHE A 1 99  ? -9.20151  -32.92094 16.91940  1.000 13.29922 ? 99  PHE A CZ  1 
ATOM   809  N N   . GLY A 1 100 ? -12.20201 -30.39918 21.32420  1.000 13.78215 ? 100 GLY A N   1 
ATOM   810  C CA  . GLY A 1 100 ? -11.93548 -28.97617 21.20531  1.000 12.43026 ? 100 GLY A CA  1 
ATOM   811  C C   . GLY A 1 100 ? -11.96934 -28.31879 22.57184  1.000 14.65906 ? 100 GLY A C   1 
ATOM   812  O O   . GLY A 1 100 ? -11.81806 -28.98274 23.59471  1.000 15.77934 ? 100 GLY A O   1 
ATOM   813  N N   . CYS A 1 101 ? -12.19955 -27.00530 22.56592  1.000 16.38460 ? 101 CYS A N   1 
ATOM   814  C CA  . CYS A 1 101 ? -12.14652 -26.27381 23.82501  1.000 14.96248 ? 101 CYS A CA  1 
ATOM   815  C C   . CYS A 1 101 ? -13.00249 -25.01764 23.73804  1.000 18.78401 ? 101 CYS A C   1 
ATOM   816  O O   . CYS A 1 101 ? -13.33811 -24.53754 22.65330  1.000 18.75352 ? 101 CYS A O   1 
ATOM   817  C CB  . CYS A 1 101 ? -10.69826 -25.91402 24.19848  1.000 20.27604 ? 101 CYS A CB  1 
ATOM   818  S SG  . CYS A 1 101 ? -9.77555  -25.09757 22.87080  1.000 28.50727 ? 101 CYS A SG  1 
ATOM   819  N N   . ASP A 1 102 ? -13.36998 -24.51409 24.90791  1.000 16.23999 ? 102 ASP A N   1 
ATOM   820  C CA  . ASP A 1 102 ? -14.00657 -23.21847 25.08219  1.000 20.27281 ? 102 ASP A CA  1 
ATOM   821  C C   . ASP A 1 102 ? -13.06214 -22.29904 25.83923  1.000 19.87016 ? 102 ASP A C   1 
ATOM   822  O O   . ASP A 1 102 ? -12.33864 -22.74172 26.73752  1.000 25.33247 ? 102 ASP A O   1 
ATOM   823  C CB  . ASP A 1 102 ? -15.29319 -23.32957 25.90069  1.000 23.63868 ? 102 ASP A CB  1 
ATOM   824  C CG  . ASP A 1 102 ? -16.34745 -24.19268 25.24676  1.000 21.23215 ? 102 ASP A CG  1 
ATOM   825  O OD1 . ASP A 1 102 ? -16.31931 -24.39956 24.00835  1.000 16.76785 ? 102 ASP A OD1 1 
ATOM   826  O OD2 . ASP A 1 102 ? -17.20898 -24.67919 26.00547  1.000 19.44243 ? 102 ASP A OD2 1 
ATOM   827  N N   . VAL A 1 103 ? -13.10160 -21.01103 25.51094  1.000 18.76391 ? 103 VAL A N   1 
ATOM   828  C CA  . VAL A 1 103 ? -12.37388 -19.99741 26.26790  1.000 22.04477 ? 103 VAL A CA  1 
ATOM   829  C C   . VAL A 1 103 ? -13.33208 -18.87995 26.65085  1.000 22.47356 ? 103 VAL A C   1 
ATOM   830  O O   . VAL A 1 103 ? -14.34223 -18.64786 25.98037  1.000 23.10172 ? 103 VAL A O   1 
ATOM   831  C CB  . VAL A 1 103 ? -11.19311 -19.40835 25.48392  1.000 22.81040 ? 103 VAL A CB  1 
ATOM   832  C CG1 . VAL A 1 103 ? -10.13150 -20.49220 25.17716  1.000 22.25476 ? 103 VAL A CG1 1 
ATOM   833  C CG2 . VAL A 1 103 ? -11.70547 -18.72112 24.20545  1.000 20.73344 ? 103 VAL A CG2 1 
ATOM   834  N N   . GLY A 1 104 ? -13.00074 -18.17797 27.73986  1.000 26.53503 ? 104 GLY A N   1 
ATOM   835  C CA  . GLY A 1 104 ? -13.76625 -17.02194 28.15717  1.000 30.18184 ? 104 GLY A CA  1 
ATOM   836  C C   . GLY A 1 104 ? -13.36460 -15.76475 27.40305  1.000 36.85021 ? 104 GLY A C   1 
ATOM   837  O O   . GLY A 1 104 ? -12.53832 -15.78673 26.48996  1.000 33.50052 ? 104 GLY A O   1 
ATOM   838  N N   . SER A 1 105 ? -13.97036 -14.64038 27.80853  1.000 36.93880 ? 105 SER A N   1 
ATOM   839  C CA  . SER A 1 105 ? -13.69470 -13.36256 27.15114  1.000 40.71641 ? 105 SER A CA  1 
ATOM   840  C C   . SER A 1 105 ? -12.22979 -12.96371 27.29269  1.000 40.52784 ? 105 SER A C   1 
ATOM   841  O O   . SER A 1 105 ? -11.64032 -12.38685 26.37155  1.000 42.42495 ? 105 SER A O   1 
ATOM   842  C CB  . SER A 1 105 ? -14.59578 -12.27302 27.72925  1.000 41.13188 ? 105 SER A CB  1 
ATOM   843  O OG  . SER A 1 105 ? -15.86563 -12.80060 28.05811  1.000 47.34370 ? 105 SER A OG  1 
ATOM   844  N N   . ASP A 1 106 ? -11.63320 -13.24501 28.44454  1.000 41.36254 ? 106 ASP A N   1 
ATOM   845  C CA  . ASP A 1 106 ? -10.22446 -12.97723 28.69052  1.000 39.42472 ? 106 ASP A CA  1 
ATOM   846  C C   . ASP A 1 106 ? -9.30810  -14.04046 28.10743  1.000 40.68229 ? 106 ASP A C   1 
ATOM   847  O O   . ASP A 1 106 ? -8.10944  -14.03300 28.40156  1.000 41.55393 ? 106 ASP A O   1 
ATOM   848  C CB  . ASP A 1 106 ? -9.98642  -12.84297 30.19219  1.000 43.15311 ? 106 ASP A CB  1 
ATOM   849  C CG  . ASP A 1 106 ? -10.29508 -14.12318 30.94242  1.000 49.97358 ? 106 ASP A CG  1 
ATOM   850  O OD1 . ASP A 1 106 ? -11.07245 -14.96037 30.41825  1.000 43.32869 ? 106 ASP A OD1 1 
ATOM   851  O OD2 . ASP A 1 106 ? -9.75869  -14.29279 32.05625  1.000 52.07608 ? 106 ASP A OD2 1 
ATOM   852  N N   . GLY A 1 107 ? -9.84260  -14.95612 27.30220  1.000 39.90509 ? 107 GLY A N   1 
ATOM   853  C CA  . GLY A 1 107 ? -9.03635  -15.94530 26.62514  1.000 36.51798 ? 107 GLY A CA  1 
ATOM   854  C C   . GLY A 1 107 ? -8.64143  -17.14855 27.45183  1.000 36.47163 ? 107 GLY A C   1 
ATOM   855  O O   . GLY A 1 107 ? -8.01287  -18.06597 26.90753  1.000 33.32077 ? 107 GLY A O   1 
ATOM   856  N N   . ARG A 1 108 ? -8.98044  -17.19083 28.74031  1.000 36.53125 ? 108 ARG A N   1 
ATOM   857  C CA  . ARG A 1 108 ? -8.51517  -18.31556 29.53606  1.000 33.87349 ? 108 ARG A CA  1 
ATOM   858  C C   . ARG A 1 108 ? -9.38186  -19.54805 29.29785  1.000 26.90100 ? 108 ARG A C   1 
ATOM   859  O O   . ARG A 1 108 ? -10.53686 -19.45653 28.88053  1.000 26.26042 ? 108 ARG A O   1 
ATOM   860  C CB  . ARG A 1 108 ? -8.48301  -17.97234 31.02890  1.000 38.48858 ? 108 ARG A CB  1 
ATOM   861  C CG  . ARG A 1 108 ? -9.74404  -17.36865 31.63960  1.000 45.26707 ? 108 ARG A CG  1 
ATOM   862  C CD  . ARG A 1 108 ? -10.81788 -18.40683 31.99120  1.000 47.27487 ? 108 ARG A CD  1 
ATOM   863  N NE  . ARG A 1 108 ? -11.80890 -17.91425 32.94654  1.000 49.51430 ? 108 ARG A NE  1 
ATOM   864  C CZ  . ARG A 1 108 ? -12.93181 -17.28277 32.62354  1.000 52.64867 ? 108 ARG A CZ  1 
ATOM   865  N NH1 . ARG A 1 108 ? -13.19265 -16.92803 31.37306  1.000 45.28659 ? 108 ARG A NH1 1 
ATOM   866  N NH2 . ARG A 1 108 ? -13.81964 -17.00593 33.58012  1.000 52.56475 ? 108 ARG A NH2 1 
ATOM   867  N N   . PHE A 1 109 ? -8.80536  -20.70783 29.60690  1.000 25.70943 ? 109 PHE A N   1 
ATOM   868  C CA  . PHE A 1 109 ? -9.46410  -21.99176 29.38836  1.000 22.62037 ? 109 PHE A CA  1 
ATOM   869  C C   . PHE A 1 109 ? -10.74575 -22.13202 30.21470  1.000 26.16230 ? 109 PHE A C   1 
ATOM   870  O O   . PHE A 1 109 ? -10.77129 -21.89584 31.42884  1.000 23.21199 ? 109 PHE A O   1 
ATOM   871  C CB  . PHE A 1 109 ? -8.50390  -23.12284 29.72399  1.000 22.96991 ? 109 PHE A CB  1 
ATOM   872  C CG  . PHE A 1 109 ? -9.11617  -24.49774 29.61788  1.000 21.66268 ? 109 PHE A CG  1 
ATOM   873  C CD1 . PHE A 1 109 ? -9.22209  -25.13187 28.38541  1.000 22.90915 ? 109 PHE A CD1 1 
ATOM   874  C CD2 . PHE A 1 109 ? -9.55010  -25.16545 30.74469  1.000 23.24194 ? 109 PHE A CD2 1 
ATOM   875  C CE1 . PHE A 1 109 ? -9.76448  -26.40622 28.28532  1.000 20.23928 ? 109 PHE A CE1 1 
ATOM   876  C CE2 . PHE A 1 109 ? -10.10409 -26.43707 30.65518  1.000 24.24215 ? 109 PHE A CE2 1 
ATOM   877  C CZ  . PHE A 1 109 ? -10.20890 -27.05808 29.43013  1.000 21.99329 ? 109 PHE A CZ  1 
ATOM   878  N N   . LEU A 1 110 ? -11.80214 -22.56705 29.55502  1.000 20.65311 ? 110 LEU A N   1 
ATOM   879  C CA  . LEU A 1 110 ? -13.09862 -22.75291 30.18907  1.000 22.19272 ? 110 LEU A CA  1 
ATOM   880  C C   . LEU A 1 110 ? -13.49346 -24.21604 30.27538  1.000 18.47998 ? 110 LEU A C   1 
ATOM   881  O O   . LEU A 1 110 ? -13.95513 -24.66539 31.31590  1.000 22.11476 ? 110 LEU A O   1 
ATOM   882  C CB  . LEU A 1 110 ? -14.14824 -21.96729 29.40632  1.000 26.87161 ? 110 LEU A CB  1 
ATOM   883  C CG  . LEU A 1 110 ? -15.12163 -21.08940 30.15328  1.000 29.21458 ? 110 LEU A CG  1 
ATOM   884  C CD1 . LEU A 1 110 ? -14.31522 -20.05678 30.88448  1.000 27.19923 ? 110 LEU A CD1 1 
ATOM   885  C CD2 . LEU A 1 110 ? -15.95812 -20.40566 29.10277  1.000 27.15764 ? 110 LEU A CD2 1 
ATOM   886  N N   . ARG A 1 111 ? -13.23891 -24.99331 29.23138  1.000 19.06897 ? 111 ARG A N   1 
ATOM   887  C CA  . ARG A 1 111 ? -13.75180 -26.35152 29.17886  1.000 17.09260 ? 111 ARG A CA  1 
ATOM   888  C C   . ARG A 1 111 ? -13.11281 -27.06574 27.98615  1.000 17.25071 ? 111 ARG A C   1 
ATOM   889  O O   . ARG A 1 111 ? -12.77094 -26.42602 26.98408  1.000 19.76518 ? 111 ARG A O   1 
ATOM   890  C CB  . ARG A 1 111 ? -15.28351 -26.32914 29.06388  1.000 21.24754 ? 111 ARG A CB  1 
ATOM   891  C CG  . ARG A 1 111 ? -15.84713 -27.57920 28.51190  1.000 22.16564 ? 111 ARG A CG  1 
ATOM   892  C CD  . ARG A 1 111 ? -16.19107 -28.54727 29.59111  1.000 27.96587 ? 111 ARG A CD  1 
ATOM   893  N NE  . ARG A 1 111 ? -17.53010 -28.23890 30.06468  1.000 34.60183 ? 111 ARG A NE  1 
ATOM   894  C CZ  . ARG A 1 111 ? -18.57722 -29.01159 29.83063  1.000 38.44458 ? 111 ARG A CZ  1 
ATOM   895  N NH1 . ARG A 1 111 ? -18.45014 -30.15715 29.17967  1.000 37.22497 ? 111 ARG A NH1 1 
ATOM   896  N NH2 . ARG A 1 111 ? -19.78081 -28.62361 30.25725  1.000 42.88864 ? 111 ARG A NH2 1 
ATOM   897  N N   . GLY A 1 112 ? -12.92641 -28.37608 28.11944  1.000 17.68897 ? 112 GLY A N   1 
ATOM   898  C CA  . GLY A 1 112 ? -12.36495 -29.18140 27.04912  1.000 19.40943 ? 112 GLY A CA  1 
ATOM   899  C C   . GLY A 1 112 ? -13.21176 -30.40646 26.77179  1.000 21.02666 ? 112 GLY A C   1 
ATOM   900  O O   . GLY A 1 112 ? -13.85429 -30.95763 27.66273  1.000 18.64870 ? 112 GLY A O   1 
ATOM   901  N N   . TYR A 1 113 ? -13.19194 -30.84354 25.51188  1.000 18.01333 ? 113 TYR A N   1 
ATOM   902  C CA  . TYR A 1 113 ? -14.05374 -31.93073 25.06480  1.000 16.99897 ? 113 TYR A CA  1 
ATOM   903  C C   . TYR A 1 113 ? -13.27158 -32.94495 24.24328  1.000 19.78845 ? 113 TYR A C   1 
ATOM   904  O O   . TYR A 1 113 ? -12.30222 -32.59978 23.56043  1.000 18.04362 ? 113 TYR A O   1 
ATOM   905  C CB  . TYR A 1 113 ? -15.20527 -31.42437 24.22558  1.000 13.09391 ? 113 TYR A CB  1 
ATOM   906  C CG  . TYR A 1 113 ? -15.96773 -30.25537 24.79912  1.000 16.18014 ? 113 TYR A CG  1 
ATOM   907  C CD1 . TYR A 1 113 ? -15.51059 -28.96496 24.62345  1.000 19.29518 ? 113 TYR A CD1 1 
ATOM   908  C CD2 . TYR A 1 113 ? -17.18395 -30.44167 25.47292  1.000 22.93574 ? 113 TYR A CD2 1 
ATOM   909  C CE1 . TYR A 1 113 ? -16.19779 -27.88979 25.11987  1.000 19.80835 ? 113 TYR A CE1 1 
ATOM   910  C CE2 . TYR A 1 113 ? -17.90571 -29.34498 25.98049  1.000 23.67805 ? 113 TYR A CE2 1 
ATOM   911  C CZ  . TYR A 1 113 ? -17.40229 -28.07312 25.78636  1.000 24.69061 ? 113 TYR A CZ  1 
ATOM   912  O OH  . TYR A 1 113 ? -18.05705 -26.95744 26.26778  1.000 24.15068 ? 113 TYR A OH  1 
ATOM   913  N N   . HIS A 1 114 ? -13.72785 -34.20000 24.30139  1.000 12.67520 ? 114 HIS A N   1 
ATOM   914  C CA  . HIS A 1 114 ? -13.06362 -35.33300 23.66403  1.000 16.60624 ? 114 HIS A CA  1 
ATOM   915  C C   . HIS A 1 114 ? -14.01488 -36.52756 23.76289  1.000 19.28707 ? 114 HIS A C   1 
ATOM   916  O O   . HIS A 1 114 ? -13.98638 -37.24895 24.76840  1.000 15.51665 ? 114 HIS A O   1 
ATOM   917  C CB  . HIS A 1 114 ? -11.70495 -35.56658 24.34953  1.000 16.11316 ? 114 HIS A CB  1 
ATOM   918  C CG  . HIS A 1 114 ? -10.87045 -36.66956 23.76745  1.000 21.10923 ? 114 HIS A CG  1 
ATOM   919  N ND1 . HIS A 1 114 ? -9.69117  -36.43104 23.08311  1.000 22.71399 ? 114 HIS A ND1 1 
ATOM   920  C CD2 . HIS A 1 114 ? -11.00358 -38.01797 23.82294  1.000 20.48077 ? 114 HIS A CD2 1 
ATOM   921  C CE1 . HIS A 1 114 ? -9.14151  -37.58400 22.73661  1.000 16.55610 ? 114 HIS A CE1 1 
ATOM   922  N NE2 . HIS A 1 114 ? -9.92302  -38.56231 23.16602  1.000 19.75748 ? 114 HIS A NE2 1 
ATOM   923  N N   . GLN A 1 115 ? -14.87289 -36.72973 22.73930  1.000 15.53660 ? 115 GLN A N   1 
ATOM   924  C CA  . GLN A 1 115 ? -16.07216 -37.56966 22.82412  1.000 16.39226 ? 115 GLN A CA  1 
ATOM   925  C C   . GLN A 1 115 ? -16.26930 -38.39489 21.56217  1.000 17.19430 ? 115 GLN A C   1 
ATOM   926  O O   . GLN A 1 115 ? -16.11000 -37.87743 20.45288  1.000 15.49291 ? 115 GLN A O   1 
ATOM   927  C CB  . GLN A 1 115 ? -17.35506 -36.73688 22.95823  1.000 15.97484 ? 115 GLN A CB  1 
ATOM   928  C CG  . GLN A 1 115 ? -17.47073 -35.95450 24.19506  1.000 24.36595 ? 115 GLN A CG  1 
ATOM   929  C CD  . GLN A 1 115 ? -18.36958 -34.74889 24.07246  1.000 20.83368 ? 115 GLN A CD  1 
ATOM   930  O OE1 . GLN A 1 115 ? -19.25723 -34.64968 23.20107  1.000 24.53889 ? 115 GLN A OE1 1 
ATOM   931  N NE2 . GLN A 1 115 ? -18.10898 -33.79817 24.91257  1.000 19.95224 ? 115 GLN A NE2 1 
ATOM   932  N N   . TYR A 1 116 ? -16.71614 -39.64039 21.73569  1.000 15.49432 ? 116 TYR A N   1 
ATOM   933  C CA  . TYR A 1 116 ? -17.02180 -40.53784 20.63016  1.000 17.76014 ? 116 TYR A CA  1 
ATOM   934  C C   . TYR A 1 116 ? -18.49605 -40.90613 20.59976  1.000 17.57369 ? 116 TYR A C   1 
ATOM   935  O O   . TYR A 1 116 ? -19.13975 -41.05358 21.64337  1.000 14.21130 ? 116 TYR A O   1 
ATOM   936  C CB  . TYR A 1 116 ? -16.22812 -41.82338 20.73997  1.000 17.07129 ? 116 TYR A CB  1 
ATOM   937  C CG  . TYR A 1 116 ? -14.84836 -41.74588 20.14815  1.000 16.27183 ? 116 TYR A CG  1 
ATOM   938  C CD1 . TYR A 1 116 ? -14.67127 -41.85431 18.77685  1.000 20.08118 ? 116 TYR A CD1 1 
ATOM   939  C CD2 . TYR A 1 116 ? -13.71685 -41.64400 20.95119  1.000 22.30406 ? 116 TYR A CD2 1 
ATOM   940  C CE1 . TYR A 1 116 ? -13.40682 -41.82001 18.20827  1.000 21.26024 ? 116 TYR A CE1 1 
ATOM   941  C CE2 . TYR A 1 116 ? -12.42998 -41.60298 20.37606  1.000 19.90105 ? 116 TYR A CE2 1 
ATOM   942  C CZ  . TYR A 1 116 ? -12.29061 -41.70001 19.00063  1.000 22.91206 ? 116 TYR A CZ  1 
ATOM   943  O OH  . TYR A 1 116 ? -11.01849 -41.67419 18.37103  1.000 25.73062 ? 116 TYR A OH  1 
ATOM   944  N N   . ALA A 1 117 ? -19.00787 -41.10984 19.39619  1.000 17.87912 ? 117 ALA A N   1 
ATOM   945  C CA  . ALA A 1 117 ? -20.29511 -41.75638 19.18504  1.000 13.00940 ? 117 ALA A CA  1 
ATOM   946  C C   . ALA A 1 117 ? -20.14150 -42.84560 18.13845  1.000 15.45811 ? 117 ALA A C   1 
ATOM   947  O O   . ALA A 1 117 ? -19.41143 -42.67258 17.15959  1.000 18.33631 ? 117 ALA A O   1 
ATOM   948  C CB  . ALA A 1 117 ? -21.37210 -40.77374 18.73286  1.000 16.29992 ? 117 ALA A CB  1 
ATOM   949  N N   . TYR A 1 118 ? -20.85372 -43.95180 18.34825  1.000 17.79571 ? 118 TYR A N   1 
ATOM   950  C CA  . TYR A 1 118 ? -20.89997 -45.09555 17.44408  1.000 18.88203 ? 118 TYR A CA  1 
ATOM   951  C C   . TYR A 1 118 ? -22.33685 -45.29079 16.97847  1.000 22.47847 ? 118 TYR A C   1 
ATOM   952  O O   . TYR A 1 118 ? -23.26146 -45.34150 17.80722  1.000 18.74340 ? 118 TYR A O   1 
ATOM   953  C CB  . TYR A 1 118 ? -20.40730 -46.35931 18.14681  1.000 19.66615 ? 118 TYR A CB  1 
ATOM   954  C CG  . TYR A 1 118 ? -20.26370 -47.57759 17.26006  1.000 19.38120 ? 118 TYR A CG  1 
ATOM   955  C CD1 . TYR A 1 118 ? -19.37249 -47.58377 16.19473  1.000 20.41535 ? 118 TYR A CD1 1 
ATOM   956  C CD2 . TYR A 1 118 ? -20.99754 -48.73136 17.50827  1.000 21.42186 ? 118 TYR A CD2 1 
ATOM   957  C CE1 . TYR A 1 118 ? -19.22339 -48.71753 15.38559  1.000 21.97140 ? 118 TYR A CE1 1 
ATOM   958  C CE2 . TYR A 1 118 ? -20.85620 -49.86884 16.71627  1.000 22.24446 ? 118 TYR A CE2 1 
ATOM   959  C CZ  . TYR A 1 118 ? -19.96719 -49.85387 15.65332  1.000 24.61597 ? 118 TYR A CZ  1 
ATOM   960  O OH  . TYR A 1 118 ? -19.84032 -50.98212 14.86742  1.000 21.78735 ? 118 TYR A OH  1 
ATOM   961  N N   . ASP A 1 119 ? -22.51085 -45.40139 15.65465  1.000 15.08983 ? 119 ASP A N   1 
ATOM   962  C CA  . ASP A 1 119 ? -23.81462 -45.50074 14.99439  1.000 20.78127 ? 119 ASP A CA  1 
ATOM   963  C C   . ASP A 1 119 ? -24.81724 -44.46905 15.51952  1.000 19.10539 ? 119 ASP A C   1 
ATOM   964  O O   . ASP A 1 119 ? -26.00427 -44.75305 15.69767  1.000 22.31145 ? 119 ASP A O   1 
ATOM   965  C CB  . ASP A 1 119 ? -24.37434 -46.92222 15.08988  1.000 21.44002 ? 119 ASP A CB  1 
ATOM   966  C CG  . ASP A 1 119 ? -23.58303 -47.92122 14.24529  1.000 27.06486 ? 119 ASP A CG  1 
ATOM   967  O OD1 . ASP A 1 119 ? -22.87830 -47.50473 13.29176  1.000 27.07578 ? 119 ASP A OD1 1 
ATOM   968  O OD2 . ASP A 1 119 ? -23.68950 -49.13378 14.51099  1.000 26.98380 ? 119 ASP A OD2 1 
ATOM   969  N N   . GLY A 1 120 ? -24.34630 -43.24172 15.71881  1.000 14.84124 ? 120 GLY A N   1 
ATOM   970  C CA  . GLY A 1 120 ? -25.21503 -42.11027 15.99869  1.000 25.01904 ? 120 GLY A CA  1 
ATOM   971  C C   . GLY A 1 120 ? -25.47163 -41.82484 17.46458  1.000 16.41603 ? 120 GLY A C   1 
ATOM   972  O O   . GLY A 1 120 ? -26.15190 -40.84177 17.77923  1.000 19.26926 ? 120 GLY A O   1 
ATOM   973  N N   . LYS A 1 121 ? -24.95271 -42.63870 18.37110  1.000 17.47613 ? 121 LYS A N   1 
ATOM   974  C CA  . LYS A 1 121 ? -25.28485 -42.52707 19.78058  1.000 17.73810 ? 121 LYS A CA  1 
ATOM   975  C C   . LYS A 1 121 ? -24.02377 -42.46348 20.62297  1.000 17.05074 ? 121 LYS A C   1 
ATOM   976  O O   . LYS A 1 121 ? -23.00013 -43.04634 20.26139  1.000 18.76215 ? 121 LYS A O   1 
ATOM   977  C CB  . LYS A 1 121 ? -26.16181 -43.69815 20.24559  1.000 22.15960 ? 121 LYS A CB  1 
ATOM   978  C CG  . LYS A 1 121 ? -27.56550 -43.58558 19.70924  1.000 25.22805 ? 121 LYS A CG  1 
ATOM   979  C CD  . LYS A 1 121 ? -28.44430 -43.15125 20.85892  1.000 30.99524 ? 121 LYS A CD  1 
ATOM   980  C CE  . LYS A 1 121 ? -29.88640 -43.21950 20.50863  1.000 34.74910 ? 121 LYS A CE  1 
ATOM   981  N NZ  . LYS A 1 121 ? -30.45407 -41.83029 20.57466  1.000 34.28848 ? 121 LYS A NZ  1 
ATOM   982  N N   . ASP A 1 122 ? -24.12567 -41.75707 21.75642  1.000 17.62976 ? 122 ASP A N   1 
ATOM   983  C CA  . ASP A 1 122 ? -23.03710 -41.68749 22.73239  1.000 18.08955 ? 122 ASP A CA  1 
ATOM   984  C C   . ASP A 1 122 ? -22.33194 -43.02391 22.87296  1.000 18.20182 ? 122 ASP A C   1 
ATOM   985  O O   . ASP A 1 122 ? -22.97890 -44.07009 23.03445  1.000 16.73517 ? 122 ASP A O   1 
ATOM   986  C CB  . ASP A 1 122 ? -23.55586 -41.27023 24.10513  1.000 19.57607 ? 122 ASP A CB  1 
ATOM   987  C CG  . ASP A 1 122 ? -23.59100 -39.77101 24.29827  1.000 23.46493 ? 122 ASP A CG  1 
ATOM   988  O OD1 . ASP A 1 122 ? -23.15787 -39.02985 23.38927  1.000 24.00599 ? 122 ASP A OD1 1 
ATOM   989  O OD2 . ASP A 1 122 ? -24.04679 -39.33492 25.38418  1.000 21.49931 ? 122 ASP A OD2 1 
ATOM   990  N N   . TYR A 1 123 ? -20.99373 -42.96556 22.83219  1.000 14.91701 ? 123 TYR A N   1 
ATOM   991  C CA  . TYR A 1 123 ? -20.13453 -44.09744 23.16784  1.000 17.48407 ? 123 TYR A CA  1 
ATOM   992  C C   . TYR A 1 123 ? -19.30356 -43.77416 24.40294  1.000 17.69379 ? 123 TYR A C   1 
ATOM   993  O O   . TYR A 1 123 ? -19.57309 -44.32540 25.46885  1.000 17.58739 ? 123 TYR A O   1 
ATOM   994  C CB  . TYR A 1 123 ? -19.24055 -44.47513 21.98163  1.000 14.50684 ? 123 TYR A CB  1 
ATOM   995  C CG  . TYR A 1 123 ? -18.43966 -45.72160 22.23518  1.000 18.41844 ? 123 TYR A CG  1 
ATOM   996  C CD1 . TYR A 1 123 ? -18.99082 -46.98093 22.02875  1.000 17.17307 ? 123 TYR A CD1 1 
ATOM   997  C CD2 . TYR A 1 123 ? -17.14677 -45.64790 22.73540  1.000 14.53245 ? 123 TYR A CD2 1 
ATOM   998  C CE1 . TYR A 1 123 ? -18.26759 -48.13560 22.29425  1.000 19.45795 ? 123 TYR A CE1 1 
ATOM   999  C CE2 . TYR A 1 123 ? -16.39841 -46.80722 22.98906  1.000 17.11136 ? 123 TYR A CE2 1 
ATOM   1000 C CZ  . TYR A 1 123 ? -16.96411 -48.04074 22.76775  1.000 15.10869 ? 123 TYR A CZ  1 
ATOM   1001 O OH  . TYR A 1 123 ? -16.24774 -49.18316 23.03902  1.000 21.44035 ? 123 TYR A OH  1 
ATOM   1002 N N   . ILE A 1 124 ? -18.28801 -42.91122 24.29774  1.000 16.57725 ? 124 ILE A N   1 
ATOM   1003 C CA  . ILE A 1 124 ? -17.50850 -42.50702 25.46429  1.000 15.70209 ? 124 ILE A CA  1 
ATOM   1004 C C   . ILE A 1 124 ? -17.16235 -41.02904 25.33047  1.000 16.05068 ? 124 ILE A C   1 
ATOM   1005 O O   . ILE A 1 124 ? -16.90022 -40.53623 24.22345  1.000 16.58369 ? 124 ILE A O   1 
ATOM   1006 C CB  . ILE A 1 124 ? -16.24301 -43.37981 25.64989  1.000 19.12741 ? 124 ILE A CB  1 
ATOM   1007 C CG1 . ILE A 1 124 ? -15.63682 -43.16601 27.04058  1.000 19.38898 ? 124 ILE A CG1 1 
ATOM   1008 C CG2 . ILE A 1 124 ? -15.17705 -43.11358 24.57578  1.000 16.25442 ? 124 ILE A CG2 1 
ATOM   1009 C CD1 . ILE A 1 124 ? -14.75239 -44.31679 27.50793  1.000 17.40977 ? 124 ILE A CD1 1 
ATOM   1010 N N   . ALA A 1 125 ? -17.15641 -40.32213 26.46601  1.000 10.81959 ? 125 ALA A N   1 
ATOM   1011 C CA  . ALA A 1 125 ? -16.96448 -38.87536 26.50615  1.000 14.22032 ? 125 ALA A CA  1 
ATOM   1012 C C   . ALA A 1 125 ? -16.10219 -38.51337 27.70832  1.000 19.36472 ? 125 ALA A C   1 
ATOM   1013 O O   . ALA A 1 125 ? -16.30586 -39.04743 28.79892  1.000 17.22172 ? 125 ALA A O   1 
ATOM   1014 C CB  . ALA A 1 125 ? -18.31958 -38.13988 26.58150  1.000 13.53947 ? 125 ALA A CB  1 
ATOM   1015 N N   . LEU A 1 126 ? -15.11944 -37.63398 27.50165  1.000 16.32091 ? 126 LEU A N   1 
ATOM   1016 C CA  . LEU A 1 126 ? -14.30634 -37.14942 28.61019  1.000 17.21992 ? 126 LEU A CA  1 
ATOM   1017 C C   . LEU A 1 126 ? -15.13590 -36.20054 29.46579  1.000 17.12030 ? 126 LEU A C   1 
ATOM   1018 O O   . LEU A 1 126 ? -15.77691 -35.28259 28.94712  1.000 21.34839 ? 126 LEU A O   1 
ATOM   1019 C CB  . LEU A 1 126 ? -13.05415 -36.42777 28.08664  1.000 20.52500 ? 126 LEU A CB  1 
ATOM   1020 C CG  . LEU A 1 126 ? -12.09563 -35.80276 29.11381  1.000 22.85145 ? 126 LEU A CG  1 
ATOM   1021 C CD1 . LEU A 1 126 ? -11.59643 -36.88195 30.05157  1.000 18.40176 ? 126 LEU A CD1 1 
ATOM   1022 C CD2 . LEU A 1 126 ? -10.91098 -35.13671 28.41659  1.000 22.26101 ? 126 LEU A CD2 1 
ATOM   1023 N N   . LYS A 1 127 ? -15.11152 -36.40562 30.77065  1.000 17.25247 ? 127 LYS A N   1 
ATOM   1024 C CA  . LYS A 1 127 ? -15.92474 -35.55607 31.61978  1.000 22.56362 ? 127 LYS A CA  1 
ATOM   1025 C C   . LYS A 1 127 ? -15.23065 -34.22298 31.84386  1.000 26.33827 ? 127 LYS A C   1 
ATOM   1026 O O   . LYS A 1 127 ? -14.02206 -34.06478 31.61995  1.000 20.35427 ? 127 LYS A O   1 
ATOM   1027 C CB  . LYS A 1 127 ? -16.21194 -36.21856 32.96687  1.000 20.54179 ? 127 LYS A CB  1 
ATOM   1028 C CG  . LYS A 1 127 ? -17.17072 -37.41154 32.91888  1.000 22.62771 ? 127 LYS A CG  1 
ATOM   1029 C CD  . LYS A 1 127 ? -17.96172 -37.51370 34.25800  1.000 26.09384 ? 127 LYS A CD  1 
ATOM   1030 C CE  . LYS A 1 127 ? -17.86622 -38.88821 34.89550  1.000 31.69393 ? 127 LYS A CE  1 
ATOM   1031 N NZ  . LYS A 1 127 ? -17.50021 -38.80049 36.35127  1.000 33.28341 ? 127 LYS A NZ  1 
ATOM   1032 N N   . GLU A 1 128 ? -16.01611 -33.26323 32.32306  1.000 20.17147 ? 128 GLU A N   1 
ATOM   1033 C CA  . GLU A 1 128 ? -15.53220 -31.90190 32.48223  1.000 27.08658 ? 128 GLU A CA  1 
ATOM   1034 C C   . GLU A 1 128 ? -14.32194 -31.81761 33.40916  1.000 25.87497 ? 128 GLU A C   1 
ATOM   1035 O O   . GLU A 1 128 ? -13.52850 -30.88398 33.28361  1.000 29.29707 ? 128 GLU A O   1 
ATOM   1036 C CB  . GLU A 1 128 ? -16.69565 -31.03879 32.97223  1.000 24.57639 ? 128 GLU A CB  1 
ATOM   1037 C CG  . GLU A 1 128 ? -16.36283 -29.65800 33.47943  1.000 30.97795 ? 128 GLU A CG  1 
ATOM   1038 C CD  . GLU A 1 128 ? -17.54241 -28.70024 33.34076  1.000 38.82808 ? 128 GLU A CD  1 
ATOM   1039 O OE1 . GLU A 1 128 ? -18.70584 -29.17233 33.29947  1.000 40.73278 ? 128 GLU A OE1 1 
ATOM   1040 O OE2 . GLU A 1 128 ? -17.30835 -27.47105 33.31722  1.000 45.12467 ? 128 GLU A OE2 1 
ATOM   1041 N N   . ASP A 1 129 ? -14.13645 -32.77916 34.31146  1.000 20.63817 ? 129 ASP A N   1 
ATOM   1042 C CA  . ASP A 1 129 ? -12.96803 -32.74137 35.17628  1.000 24.99232 ? 129 ASP A CA  1 
ATOM   1043 C C   . ASP A 1 129 ? -11.69160 -33.17785 34.45966  1.000 28.60814 ? 129 ASP A C   1 
ATOM   1044 O O   . ASP A 1 129 ? -10.61404 -33.14010 35.06488  1.000 24.56142 ? 129 ASP A O   1 
ATOM   1045 C CB  . ASP A 1 129 ? -13.21874 -33.58220 36.44085  1.000 26.07590 ? 129 ASP A CB  1 
ATOM   1046 C CG  . ASP A 1 129 ? -13.32101 -35.09782 36.16824  1.000 32.31979 ? 129 ASP A CG  1 
ATOM   1047 O OD1 . ASP A 1 129 ? -13.06092 -35.55692 35.03089  1.000 32.97707 ? 129 ASP A OD1 1 
ATOM   1048 O OD2 . ASP A 1 129 ? -13.66012 -35.84488 37.12281  1.000 29.93826 ? 129 ASP A OD2 1 
ATOM   1049 N N   . LEU A 1 130 ? -11.78400 -33.57766 33.18625  1.000 29.46974 ? 130 LEU A N   1 
ATOM   1050 C CA  . LEU A 1 130 ? -10.62569 -33.98373 32.39218  1.000 23.25223 ? 130 LEU A CA  1 
ATOM   1051 C C   . LEU A 1 130 ? -9.84306  -35.09610 33.07091  1.000 25.64436 ? 130 LEU A C   1 
ATOM   1052 O O   . LEU A 1 130 ? -8.65332  -35.27650 32.81469  1.000 26.16823 ? 130 LEU A O   1 
ATOM   1053 C CB  . LEU A 1 130 ? -9.71061  -32.78890 32.10634  1.000 26.83622 ? 130 LEU A CB  1 
ATOM   1054 C CG  . LEU A 1 130 ? -10.35116 -31.58883 31.41767  1.000 28.18461 ? 130 LEU A CG  1 
ATOM   1055 C CD1 . LEU A 1 130 ? -9.26098  -30.62406 30.93962  1.000 29.18493 ? 130 LEU A CD1 1 
ATOM   1056 C CD2 . LEU A 1 130 ? -11.27599 -32.03701 30.26324  1.000 21.79351 ? 130 LEU A CD2 1 
ATOM   1057 N N   . ARG A 1 131 ? -10.51169 -35.82655 33.95544  1.000 24.93903 ? 131 ARG A N   1 
ATOM   1058 C CA  . ARG A 1 131 ? -9.94348  -36.94819 34.67203  1.000 26.66407 ? 131 ARG A CA  1 
ATOM   1059 C C   . ARG A 1 131 ? -10.68082 -38.25358 34.44413  1.000 25.55597 ? 131 ARG A C   1 
ATOM   1060 O O   . ARG A 1 131 ? -10.09448 -39.31590 34.66200  1.000 27.95040 ? 131 ARG A O   1 
ATOM   1061 C CB  . ARG A 1 131 ? -9.96221  -36.67890 36.18259  1.000 33.59565 ? 131 ARG A CB  1 
ATOM   1062 C CG  . ARG A 1 131 ? -8.73480  -37.11441 36.92461  1.000 39.13917 ? 131 ARG A CG  1 
ATOM   1063 C CD  . ARG A 1 131 ? -8.53151  -36.28547 38.19112  1.000 41.63202 ? 131 ARG A CD  1 
ATOM   1064 N NE  . ARG A 1 131 ? -7.93413  -34.97640 37.96383  1.000 41.94841 ? 131 ARG A NE  1 
ATOM   1065 C CZ  . ARG A 1 131 ? -6.63506  -34.79459 37.77228  1.000 44.81437 ? 131 ARG A CZ  1 
ATOM   1066 N NH1 . ARG A 1 131 ? -5.81043  -35.82365 37.63259  1.000 44.33503 ? 131 ARG A NH1 1 
ATOM   1067 N NH2 . ARG A 1 131 ? -6.14940  -33.55479 37.72953  1.000 40.96224 ? 131 ARG A NH2 1 
ATOM   1068 N N   . SER A 1 132 ? -11.94633 -38.20794 34.03508  1.000 23.57286 ? 132 SER A N   1 
ATOM   1069 C CA  . SER A 1 132 ? -12.81548 -39.36884 34.11495  1.000 26.28623 ? 132 SER A CA  1 
ATOM   1070 C C   . SER A 1 132 ? -13.66196 -39.44230 32.85513  1.000 20.20524 ? 132 SER A C   1 
ATOM   1071 O O   . SER A 1 132 ? -13.77480 -38.47490 32.09822  1.000 18.57791 ? 132 SER A O   1 
ATOM   1072 C CB  . SER A 1 132 ? -13.69871 -39.30041 35.36324  1.000 24.25026 ? 132 SER A CB  1 
ATOM   1073 O OG  . SER A 1 132 ? -14.27820 -38.00799 35.46752  1.000 30.46972 ? 132 SER A OG  1 
ATOM   1074 N N   . TRP A 1 133 ? -14.27308 -40.60406 32.64839  1.000 23.61665 ? 133 TRP A N   1 
ATOM   1075 C CA  . TRP A 1 133 ? -15.00682 -40.90426 31.43075  1.000 20.80552 ? 133 TRP A CA  1 
ATOM   1076 C C   . TRP A 1 133 ? -16.45148 -41.23630 31.76638  1.000 22.76805 ? 133 TRP A C   1 
ATOM   1077 O O   . TRP A 1 133 ? -16.72482 -41.86737 32.78943  1.000 20.14036 ? 133 TRP A O   1 
ATOM   1078 C CB  . TRP A 1 133 ? -14.34657 -42.07165 30.68602  1.000 17.99950 ? 133 TRP A CB  1 
ATOM   1079 C CG  . TRP A 1 133 ? -12.89023 -41.76617 30.33421  1.000 19.13774 ? 133 TRP A CG  1 
ATOM   1080 C CD1 . TRP A 1 133 ? -11.77132 -42.13337 31.03449  1.000 15.98264 ? 133 TRP A CD1 1 
ATOM   1081 C CD2 . TRP A 1 133 ? -12.42796 -41.01042 29.21366  1.000 20.71658 ? 133 TRP A CD2 1 
ATOM   1082 N NE1 . TRP A 1 133 ? -10.64362 -41.65080 30.41503  1.000 20.58043 ? 133 TRP A NE1 1 
ATOM   1083 C CE2 . TRP A 1 133 ? -11.01788 -40.95828 29.29370  1.000 19.17141 ? 133 TRP A CE2 1 
ATOM   1084 C CE3 . TRP A 1 133 ? -13.06669 -40.38000 28.14576  1.000 16.28676 ? 133 TRP A CE3 1 
ATOM   1085 C CZ2 . TRP A 1 133 ? -10.24335 -40.30325 28.34041  1.000 19.43965 ? 133 TRP A CZ2 1 
ATOM   1086 C CZ3 . TRP A 1 133 ? -12.30763 -39.73295 27.20994  1.000 14.45481 ? 133 TRP A CZ3 1 
ATOM   1087 C CH2 . TRP A 1 133 ? -10.90354 -39.70214 27.30481  1.000 19.09205 ? 133 TRP A CH2 1 
ATOM   1088 N N   . THR A 1 134 ? -17.37370 -40.78668 30.92012  1.000 17.80022 ? 134 THR A N   1 
ATOM   1089 C CA  . THR A 1 134 ? -18.74429 -41.29575 30.91922  1.000 20.66302 ? 134 THR A CA  1 
ATOM   1090 C C   . THR A 1 134 ? -18.92932 -42.23191 29.72521  1.000 20.94137 ? 134 THR A C   1 
ATOM   1091 O O   . THR A 1 134 ? -18.80493 -41.81037 28.56982  1.000 17.93866 ? 134 THR A O   1 
ATOM   1092 C CB  . THR A 1 134 ? -19.77843 -40.16352 30.91857  1.000 18.98704 ? 134 THR A CB  1 
ATOM   1093 O OG1 . THR A 1 134 ? -21.09584 -40.72994 30.90381  1.000 21.93865 ? 134 THR A OG1 1 
ATOM   1094 C CG2 . THR A 1 134 ? -19.60871 -39.20060 29.74931  1.000 23.66684 ? 134 THR A CG2 1 
ATOM   1095 N N   . ALA A 1 135 ? -19.16551 -43.51356 30.01556  1.000 20.95448 ? 135 ALA A N   1 
ATOM   1096 C CA  . ALA A 1 135 ? -19.39553 -44.53905 29.00732  1.000 20.23773 ? 135 ALA A CA  1 
ATOM   1097 C C   . ALA A 1 135 ? -20.88145 -44.86828 28.92796  1.000 25.83580 ? 135 ALA A C   1 
ATOM   1098 O O   . ALA A 1 135 ? -21.55302 -45.00943 29.95924  1.000 21.24275 ? 135 ALA A O   1 
ATOM   1099 C CB  . ALA A 1 135 ? -18.60258 -45.80649 29.33402  1.000 23.14763 ? 135 ALA A CB  1 
ATOM   1100 N N   . ALA A 1 136 ? -21.38091 -45.03569 27.69595  1.000 20.97052 ? 136 ALA A N   1 
ATOM   1101 C CA  . ALA A 1 136 ? -22.82289 -45.12593 27.47202  1.000 25.34813 ? 136 ALA A CA  1 
ATOM   1102 C C   . ALA A 1 136 ? -23.38630 -46.53097 27.66464  1.000 22.88420 ? 136 ALA A C   1 
ATOM   1103 O O   . ALA A 1 136 ? -24.57115 -46.66908 27.99514  1.000 24.64283 ? 136 ALA A O   1 
ATOM   1104 C CB  . ALA A 1 136 ? -23.16528 -44.62275 26.06765  1.000 19.95937 ? 136 ALA A CB  1 
ATOM   1105 N N   . ASP A 1 137 ? -22.58906 -47.57339 27.44512  1.000 24.85022 ? 137 ASP A N   1 
ATOM   1106 C CA  . ASP A 1 137 ? -23.08682 -48.94552 27.50343  1.000 19.57834 ? 137 ASP A CA  1 
ATOM   1107 C C   . ASP A 1 137 ? -21.94412 -49.86507 27.91313  1.000 22.95359 ? 137 ASP A C   1 
ATOM   1108 O O   . ASP A 1 137 ? -20.84613 -49.40686 28.24918  1.000 22.86133 ? 137 ASP A O   1 
ATOM   1109 C CB  . ASP A 1 137 ? -23.72634 -49.34510 26.16703  1.000 20.21228 ? 137 ASP A CB  1 
ATOM   1110 C CG  . ASP A 1 137 ? -22.75269 -49.26554 24.98673  1.000 25.38384 ? 137 ASP A CG  1 
ATOM   1111 O OD1 . ASP A 1 137 ? -21.54552 -49.55452 25.16063  1.000 22.53451 ? 137 ASP A OD1 1 
ATOM   1112 O OD2 . ASP A 1 137 ? -23.20776 -48.93245 23.86306  1.000 26.59516 ? 137 ASP A OD2 1 
ATOM   1113 N N   . MET A 1 138 ? -22.20271 -51.17816 27.87262  1.000 22.27448 ? 138 MET A N   1 
ATOM   1114 C CA  . MET A 1 138 ? -21.20097 -52.13934 28.32033  1.000 25.29116 ? 138 MET A CA  1 
ATOM   1115 C C   . MET A 1 138 ? -20.02498 -52.22735 27.36561  1.000 23.72108 ? 138 MET A C   1 
ATOM   1116 O O   . MET A 1 138 ? -18.90551 -52.54321 27.79144  1.000 24.93291 ? 138 MET A O   1 
ATOM   1117 C CB  . MET A 1 138 ? -21.81893 -53.51837 28.49783  1.000 28.40544 ? 138 MET A CB  1 
ATOM   1118 C CG  . MET A 1 138 ? -22.82949 -53.60851 29.63053  1.000 31.77987 ? 138 MET A CG  1 
ATOM   1119 S SD  . MET A 1 138 ? -23.52653 -55.26711 29.69028  1.000 62.06126 ? 138 MET A SD  1 
ATOM   1120 C CE  . MET A 1 138 ? -22.02841 -56.26083 29.68885  1.000 35.34224 ? 138 MET A CE  1 
ATOM   1121 N N   . ALA A 1 139 ? -20.25851 -51.99092 26.07350  1.000 22.59388 ? 139 ALA A N   1 
ATOM   1122 C CA  . ALA A 1 139 ? -19.14905 -51.93201 25.12762  1.000 23.94975 ? 139 ALA A CA  1 
ATOM   1123 C C   . ALA A 1 139 ? -18.17408 -50.82317 25.50127  1.000 23.75835 ? 139 ALA A C   1 
ATOM   1124 O O   . ALA A 1 139 ? -16.95865 -51.04330 25.59221  1.000 26.84338 ? 139 ALA A O   1 
ATOM   1125 C CB  . ALA A 1 139 ? -19.68656 -51.72235 23.71249  1.000 25.89321 ? 139 ALA A CB  1 
ATOM   1126 N N   . ALA A 1 140 ? -18.69271 -49.61934 25.72263  1.000 21.56698 ? 140 ALA A N   1 
ATOM   1127 C CA  . ALA A 1 140 ? -17.83022 -48.50204 26.07418  1.000 23.75649 ? 140 ALA A CA  1 
ATOM   1128 C C   . ALA A 1 140 ? -17.20139 -48.66026 27.45530  1.000 24.95653 ? 140 ALA A C   1 
ATOM   1129 O O   . ALA A 1 140 ? -16.14488 -48.06465 27.70282  1.000 22.72379 ? 140 ALA A O   1 
ATOM   1130 C CB  . ALA A 1 140 ? -18.61923 -47.19886 25.99314  1.000 21.39038 ? 140 ALA A CB  1 
ATOM   1131 N N   . GLN A 1 141 ? -17.80861 -49.44400 28.35904  1.000 19.50130 ? 141 GLN A N   1 
ATOM   1132 C CA  . GLN A 1 141 ? -17.15757 -49.68639 29.64354  1.000 26.54177 ? 141 GLN A CA  1 
ATOM   1133 C C   . GLN A 1 141 ? -15.86729 -50.47843 29.47590  1.000 21.47846 ? 141 GLN A C   1 
ATOM   1134 O O   . GLN A 1 141 ? -14.94652 -50.32040 30.28004  1.000 26.02860 ? 141 GLN A O   1 
ATOM   1135 C CB  . GLN A 1 141 ? -18.07600 -50.42559 30.61308  1.000 24.45195 ? 141 GLN A CB  1 
ATOM   1136 C CG  . GLN A 1 141 ? -19.31434 -49.64887 31.07775  1.000 26.12879 ? 141 GLN A CG  1 
ATOM   1137 C CD  . GLN A 1 141 ? -20.32746 -50.57933 31.73652  1.000 35.34613 ? 141 GLN A CD  1 
ATOM   1138 O OE1 . GLN A 1 141 ? -19.94746 -51.58538 32.33905  1.000 34.27874 ? 141 GLN A OE1 1 
ATOM   1139 N NE2 . GLN A 1 141 ? -21.62119 -50.26775 31.59748  1.000 28.20091 ? 141 GLN A NE2 1 
ATOM   1140 N N   . ILE A 1 142 ? -15.79823 -51.36749 28.48407  1.000 21.05437 ? 142 ILE A N   1 
ATOM   1141 C CA  . ILE A 1 142 ? -14.51989 -51.99098 28.14252  1.000 25.75374 ? 142 ILE A CA  1 
ATOM   1142 C C   . ILE A 1 142 ? -13.46443 -50.92094 27.90600  1.000 21.68703 ? 142 ILE A C   1 
ATOM   1143 O O   . ILE A 1 142 ? -12.38092 -50.94732 28.49395  1.000 24.54725 ? 142 ILE A O   1 
ATOM   1144 C CB  . ILE A 1 142 ? -14.66155 -52.91067 26.91195  1.000 22.78189 ? 142 ILE A CB  1 
ATOM   1145 C CG1 . ILE A 1 142 ? -15.78590 -53.92378 27.08908  1.000 23.18757 ? 142 ILE A CG1 1 
ATOM   1146 C CG2 . ILE A 1 142 ? -13.34527 -53.61701 26.60488  1.000 19.49015 ? 142 ILE A CG2 1 
ATOM   1147 C CD1 . ILE A 1 142 ? -15.38525 -55.06492 27.98234  1.000 26.01199 ? 142 ILE A CD1 1 
ATOM   1148 N N   . THR A 1 143 ? -13.77828 -49.96294 27.02949  1.000 24.44627 ? 143 THR A N   1 
ATOM   1149 C CA  . THR A 1 143 ? -12.83442 -48.90945 26.67113  1.000 21.33457 ? 143 THR A CA  1 
ATOM   1150 C C   . THR A 1 143 ? -12.53889 -48.01009 27.86007  1.000 23.95794 ? 143 THR A C   1 
ATOM   1151 O O   . THR A 1 143 ? -11.39343 -47.57031 28.05738  1.000 20.48282 ? 143 THR A O   1 
ATOM   1152 C CB  . THR A 1 143 ? -13.40670 -48.08106 25.51518  1.000 17.14973 ? 143 THR A CB  1 
ATOM   1153 O OG1 . THR A 1 143 ? -13.77326 -48.95365 24.43550  1.000 24.85538 ? 143 THR A OG1 1 
ATOM   1154 C CG2 . THR A 1 143 ? -12.37275 -47.06511 25.02979  1.000 21.07212 ? 143 THR A CG2 1 
ATOM   1155 N N   . LYS A 1 144 ? -13.56778 -47.71858 28.65824  1.000 19.83947 ? 144 LYS A N   1 
ATOM   1156 C CA  . LYS A 1 144 ? -13.39092 -46.83981 29.80363  1.000 19.21129 ? 144 LYS A CA  1 
ATOM   1157 C C   . LYS A 1 144 ? -12.31965 -47.38369 30.74733  1.000 22.97094 ? 144 LYS A C   1 
ATOM   1158 O O   . LYS A 1 144 ? -11.41421 -46.65010 31.15138  1.000 22.96353 ? 144 LYS A O   1 
ATOM   1159 C CB  . LYS A 1 144 ? -14.72832 -46.64553 30.52182  1.000 19.33179 ? 144 LYS A CB  1 
ATOM   1160 C CG  . LYS A 1 144 ? -14.60905 -46.26817 31.98920  1.000 24.38197 ? 144 LYS A CG  1 
ATOM   1161 C CD  . LYS A 1 144 ? -15.71406 -45.28874 32.37245  1.000 31.30271 ? 144 LYS A CD  1 
ATOM   1162 C CE  . LYS A 1 144 ? -15.64590 -44.89201 33.83650  1.000 28.66331 ? 144 LYS A CE  1 
ATOM   1163 N NZ  . LYS A 1 144 ? -16.99891 -44.85289 34.42020  1.000 28.29661 ? 144 LYS A NZ  1 
ATOM   1164 N N   . ARG A 1 145 ? -12.36283 -48.67474 31.07910  1.000 20.60698 ? 145 ARG A N   1 
ATOM   1165 C CA  . ARG A 1 145 ? -11.32376 -49.12541 32.00624  1.000 26.41853 ? 145 ARG A CA  1 
ATOM   1166 C C   . ARG A 1 145 ? -9.96838  -49.28136 31.32789  1.000 21.39344 ? 145 ARG A C   1 
ATOM   1167 O O   . ARG A 1 145 ? -8.93909  -49.13216 31.98867  1.000 23.80553 ? 145 ARG A O   1 
ATOM   1168 C CB  . ARG A 1 145 ? -11.68694 -50.42707 32.71972  1.000 31.08885 ? 145 ARG A CB  1 
ATOM   1169 C CG  . ARG A 1 145 ? -12.69926 -51.31985 32.08706  1.000 35.51727 ? 145 ARG A CG  1 
ATOM   1170 C CD  . ARG A 1 145 ? -12.84840 -52.59154 32.94375  1.000 41.16306 ? 145 ARG A CD  1 
ATOM   1171 N NE  . ARG A 1 145 ? -13.79325 -53.52091 32.34480  1.000 36.41610 ? 145 ARG A NE  1 
ATOM   1172 C CZ  . ARG A 1 145 ? -15.10405 -53.33166 32.27295  1.000 36.90819 ? 145 ARG A CZ  1 
ATOM   1173 N NH1 . ARG A 1 145 ? -15.71033 -52.37635 32.96813  1.000 41.23236 ? 145 ARG A NH1 1 
ATOM   1174 N NH2 . ARG A 1 145 ? -15.82777 -54.13182 31.49929  1.000 31.61281 ? 145 ARG A NH2 1 
ATOM   1175 N N   . LYS A 1 146 ? -9.93101  -49.58194 30.02701  1.000 22.14469 ? 146 LYS A N   1 
ATOM   1176 C CA  . LYS A 1 146 ? -8.66008  -49.52704 29.31295  1.000 20.52624 ? 146 LYS A CA  1 
ATOM   1177 C C   . LYS A 1 146 ? -8.06199  -48.13089 29.39286  1.000 21.29922 ? 146 LYS A C   1 
ATOM   1178 O O   . LYS A 1 146 ? -6.88368  -47.96462 29.71718  1.000 20.16664 ? 146 LYS A O   1 
ATOM   1179 C CB  . LYS A 1 146 ? -8.85708  -49.94912 27.85722  1.000 22.76271 ? 146 LYS A CB  1 
ATOM   1180 C CG  . LYS A 1 146 ? -9.30802  -51.38896 27.69888  1.000 27.25693 ? 146 LYS A CG  1 
ATOM   1181 C CD  . LYS A 1 146 ? -8.87394  -51.98368 26.35066  1.000 28.98653 ? 146 LYS A CD  1 
ATOM   1182 C CE  . LYS A 1 146 ? -9.74373  -53.18454 25.96580  1.000 33.39772 ? 146 LYS A CE  1 
ATOM   1183 N NZ  . LYS A 1 146 ? -9.53165  -53.62856 24.55862  1.000 33.08578 ? 146 LYS A NZ  1 
ATOM   1184 N N   . TRP A 1 147 ? -8.87213  -47.10766 29.13315  1.000 19.68141 ? 147 TRP A N   1 
ATOM   1185 C CA  . TRP A 1 147 ? -8.34279  -45.75058 29.10988  1.000 17.47502 ? 147 TRP A CA  1 
ATOM   1186 C C   . TRP A 1 147 ? -8.03665  -45.23521 30.51936  1.000 22.34935 ? 147 TRP A C   1 
ATOM   1187 O O   . TRP A 1 147 ? -7.11291  -44.42571 30.68756  1.000 19.84102 ? 147 TRP A O   1 
ATOM   1188 C CB  . TRP A 1 147 ? -9.31748  -44.82832 28.36497  1.000 20.00093 ? 147 TRP A CB  1 
ATOM   1189 C CG  . TRP A 1 147 ? -9.32959  -45.05735 26.85971  1.000 18.25912 ? 147 TRP A CG  1 
ATOM   1190 C CD1 . TRP A 1 147 ? -8.66210  -46.03410 26.17728  1.000 18.25499 ? 147 TRP A CD1 1 
ATOM   1191 C CD2 . TRP A 1 147 ? -10.05599 -44.30631 25.86920  1.000 15.28397 ? 147 TRP A CD2 1 
ATOM   1192 N NE1 . TRP A 1 147 ? -8.91620  -45.93333 24.82500  1.000 18.84757 ? 147 TRP A NE1 1 
ATOM   1193 C CE2 . TRP A 1 147 ? -9.76573  -44.87844 24.61210  1.000 17.90408 ? 147 TRP A CE2 1 
ATOM   1194 C CE3 . TRP A 1 147 ? -10.91016 -43.20265 25.92373  1.000 18.62213 ? 147 TRP A CE3 1 
ATOM   1195 C CZ2 . TRP A 1 147 ? -10.31902 -44.39460 23.42430  1.000 16.51556 ? 147 TRP A CZ2 1 
ATOM   1196 C CZ3 . TRP A 1 147 ? -11.44793 -42.71545 24.74246  1.000 19.51567 ? 147 TRP A CZ3 1 
ATOM   1197 C CH2 . TRP A 1 147 ? -11.14812 -43.30420 23.51270  1.000 17.60789 ? 147 TRP A CH2 1 
ATOM   1198 N N   . GLU A 1 148 ? -8.78155  -45.68593 31.54368  1.000 22.76171 ? 148 GLU A N   1 
ATOM   1199 C CA  . GLU A 1 148 ? -8.41777  -45.35036 32.92346  1.000 19.26532 ? 148 GLU A CA  1 
ATOM   1200 C C   . GLU A 1 148 ? -7.06304  -45.94924 33.30014  1.000 23.64220 ? 148 GLU A C   1 
ATOM   1201 O O   . GLU A 1 148 ? -6.18892  -45.25563 33.83249  1.000 23.21948 ? 148 GLU A O   1 
ATOM   1202 C CB  . GLU A 1 148 ? -9.51714  -45.80987 33.90683  1.000 22.30766 ? 148 GLU A CB  1 
ATOM   1203 C CG  . GLU A 1 148 ? -10.83518 -45.07445 33.73243  1.000 19.12467 ? 148 GLU A CG  1 
ATOM   1204 C CD  . GLU A 1 148 ? -12.00820 -45.66080 34.53358  1.000 28.04254 ? 148 GLU A CD  1 
ATOM   1205 O OE1 . GLU A 1 148 ? -12.05574 -46.89050 34.78796  1.000 21.99371 ? 148 GLU A OE1 1 
ATOM   1206 O OE2 . GLU A 1 148 ? -12.90655 -44.87454 34.89409  1.000 27.75792 ? 148 GLU A OE2 1 
ATOM   1207 N N   . ALA A 1 149 ? -6.86000  -47.23492 33.01337  1.000 22.14377 ? 149 ALA A N   1 
ATOM   1208 C CA  . ALA A 1 149 ? -5.57800  -47.86870 33.32361  1.000 26.90707 ? 149 ALA A CA  1 
ATOM   1209 C C   . ALA A 1 149 ? -4.41615  -47.19860 32.59669  1.000 22.67498 ? 149 ALA A C   1 
ATOM   1210 O O   . ALA A 1 149 ? -3.31731  -47.07261 33.15186  1.000 26.41427 ? 149 ALA A O   1 
ATOM   1211 C CB  . ALA A 1 149 ? -5.62580  -49.35552 32.97319  1.000 23.32512 ? 149 ALA A CB  1 
ATOM   1212 N N   . ALA A 1 150 ? -4.61910  -46.78831 31.34780  1.000 22.84483 ? 150 ALA A N   1 
ATOM   1213 C CA  . ALA A 1 150 ? -3.53504  -46.18459 30.58330  1.000 23.29806 ? 150 ALA A CA  1 
ATOM   1214 C C   . ALA A 1 150 ? -3.44406  -44.67795 30.78116  1.000 22.58823 ? 150 ALA A C   1 
ATOM   1215 O O   . ALA A 1 150 ? -2.54504  -44.04125 30.20854  1.000 24.73076 ? 150 ALA A O   1 
ATOM   1216 C CB  . ALA A 1 150 ? -3.68774  -46.51136 29.09246  1.000 25.21604 ? 150 ALA A CB  1 
ATOM   1217 N N   . HIS A 1 151 ? -4.34595  -44.09865 31.56903  1.000 16.67033 ? 151 HIS A N   1 
ATOM   1218 C CA  . HIS A 1 151 ? -4.34553  -42.66193 31.86404  1.000 23.40348 ? 151 HIS A CA  1 
ATOM   1219 C C   . HIS A 1 151 ? -4.42288  -41.84390 30.58224  1.000 22.13880 ? 151 HIS A C   1 
ATOM   1220 O O   . HIS A 1 151 ? -3.66631  -40.89375 30.38792  1.000 18.58232 ? 151 HIS A O   1 
ATOM   1221 C CB  . HIS A 1 151 ? -3.11405  -42.25871 32.67984  1.000 19.76701 ? 151 HIS A CB  1 
ATOM   1222 C CG  . HIS A 1 151 ? -2.96240  -43.02627 33.95174  1.000 23.16436 ? 151 HIS A CG  1 
ATOM   1223 N ND1 . HIS A 1 151 ? -3.47558  -42.58828 35.15272  1.000 23.06851 ? 151 HIS A ND1 1 
ATOM   1224 C CD2 . HIS A 1 151 ? -2.41370  -44.23955 34.19481  1.000 23.39834 ? 151 HIS A CD2 1 
ATOM   1225 C CE1 . HIS A 1 151 ? -3.22016  -43.48375 36.08896  1.000 25.00544 ? 151 HIS A CE1 1 
ATOM   1226 N NE2 . HIS A 1 151 ? -2.57600  -44.49394 35.53401  1.000 26.72794 ? 151 HIS A NE2 1 
ATOM   1227 N N   . VAL A 1 152 ? -5.35391  -42.22513 29.70321  1.000 15.71178 ? 152 VAL A N   1 
ATOM   1228 C CA  . VAL A 1 152 ? -5.53329  -41.48796 28.45942  1.000 16.32636 ? 152 VAL A CA  1 
ATOM   1229 C C   . VAL A 1 152 ? -6.02678  -40.06487 28.71700  1.000 18.80330 ? 152 VAL A C   1 
ATOM   1230 O O   . VAL A 1 152 ? -5.63452  -39.13127 28.01081  1.000 16.70055 ? 152 VAL A O   1 
ATOM   1231 C CB  . VAL A 1 152 ? -6.48562  -42.26259 27.54239  1.000 17.60575 ? 152 VAL A CB  1 
ATOM   1232 C CG1 . VAL A 1 152 ? -6.98029  -41.37129 26.42212  1.000 17.11181 ? 152 VAL A CG1 1 
ATOM   1233 C CG2 . VAL A 1 152 ? -5.78254  -43.50164 27.00555  1.000 21.46199 ? 152 VAL A CG2 1 
ATOM   1234 N N   . ALA A 1 153 ? -6.88007  -39.85785 29.72727  1.000 19.39367 ? 153 ALA A N   1 
ATOM   1235 C CA  . ALA A 1 153 ? -7.36884  -38.50243 29.99169  1.000 16.90762 ? 153 ALA A CA  1 
ATOM   1236 C C   . ALA A 1 153 ? -6.22461  -37.54513 30.32452  1.000 19.74000 ? 153 ALA A C   1 
ATOM   1237 O O   . ALA A 1 153 ? -6.11206  -36.46566 29.72354  1.000 16.56274 ? 153 ALA A O   1 
ATOM   1238 C CB  . ALA A 1 153 ? -8.40019  -38.51340 31.12162  1.000 18.46998 ? 153 ALA A CB  1 
ATOM   1239 N N   . GLU A 1 154 ? -5.37980  -37.90750 31.30239  1.000 16.29971 ? 154 GLU A N   1 
ATOM   1240 C CA  . GLU A 1 154 ? -4.24240  -37.05704 31.65428  1.000 19.08781 ? 154 GLU A CA  1 
ATOM   1241 C C   . GLU A 1 154 ? -3.40255  -36.70462 30.42954  1.000 20.09358 ? 154 GLU A C   1 
ATOM   1242 O O   . GLU A 1 154 ? -3.00916  -35.54660 30.24607  1.000 19.03036 ? 154 GLU A O   1 
ATOM   1243 C CB  . GLU A 1 154 ? -3.35239  -37.71578 32.73087  1.000 19.31629 ? 154 GLU A CB  1 
ATOM   1244 C CG  . GLU A 1 154 ? -3.93630  -37.92506 34.16083  1.000 23.31127 ? 154 GLU A CG  1 
ATOM   1245 C CD  . GLU A 1 154 ? -5.18795  -38.79394 34.28568  1.000 29.51781 ? 154 GLU A CD  1 
ATOM   1246 O OE1 . GLU A 1 154 ? -5.45888  -39.63971 33.40204  1.000 20.59226 ? 154 GLU A OE1 1 
ATOM   1247 O OE2 . GLU A 1 154 ? -5.87889  -38.64014 35.32202  1.000 28.59442 ? 154 GLU A OE2 1 
ATOM   1248 N N   . GLN A 1 155 ? -3.15736  -37.67806 29.56191  1.000 19.17267 ? 155 GLN A N   1 
ATOM   1249 C CA  . GLN A 1 155 ? -2.31816  -37.43724 28.39744  1.000 22.63892 ? 155 GLN A CA  1 
ATOM   1250 C C   . GLN A 1 155 ? -2.96431  -36.52103 27.36499  1.000 20.73798 ? 155 GLN A C   1 
ATOM   1251 O O   . GLN A 1 155 ? -2.26665  -36.07703 26.44066  1.000 20.91123 ? 155 GLN A O   1 
ATOM   1252 C CB  . GLN A 1 155 ? -1.92690  -38.75703 27.74258  1.000 20.69054 ? 155 GLN A CB  1 
ATOM   1253 C CG  . GLN A 1 155 ? -1.38828  -39.77872 28.71959  1.000 22.37376 ? 155 GLN A CG  1 
ATOM   1254 C CD  . GLN A 1 155 ? -0.79742  -40.97654 28.00404  1.000 30.29163 ? 155 GLN A CD  1 
ATOM   1255 O OE1 . GLN A 1 155 ? -0.80206  -41.03679 26.77766  1.000 41.41599 ? 155 GLN A OE1 1 
ATOM   1256 N NE2 . GLN A 1 155 ? -0.32970  -41.95063 28.76063  1.000 33.91930 ? 155 GLN A NE2 1 
ATOM   1257 N N   . GLN A 1 156 ? -4.25606  -36.20795 27.50651  1.000 17.16988 ? 156 GLN A N   1 
ATOM   1258 C CA  . GLN A 1 156 ? -4.91709  -35.24664 26.63632  1.000 20.54338 ? 156 GLN A CA  1 
ATOM   1259 C C   . GLN A 1 156 ? -4.89636  -33.82554 27.20363  1.000 17.26222 ? 156 GLN A C   1 
ATOM   1260 O O   . GLN A 1 156 ? -5.24340  -32.88347 26.48165  1.000 18.05502 ? 156 GLN A O   1 
ATOM   1261 C CB  . GLN A 1 156 ? -6.38657  -35.64836 26.41167  1.000 19.87010 ? 156 GLN A CB  1 
ATOM   1262 C CG  . GLN A 1 156 ? -6.69775  -36.91217 25.58343  1.000 19.07846 ? 156 GLN A CG  1 
ATOM   1263 C CD  . GLN A 1 156 ? -5.58841  -37.36812 24.66053  1.000 24.29397 ? 156 GLN A CD  1 
ATOM   1264 O OE1 . GLN A 1 156 ? -5.33988  -36.75421 23.60735  1.000 22.27981 ? 156 GLN A OE1 1 
ATOM   1265 N NE2 . GLN A 1 156 ? -4.93027  -38.46878 25.02786  1.000 23.13910 ? 156 GLN A NE2 1 
ATOM   1266 N N   . ARG A 1 157 ? -4.52764  -33.63806 28.48157  1.000 16.77253 ? 157 ARG A N   1 
ATOM   1267 C CA  . ARG A 1 157 ? -4.71205  -32.32560 29.10215  1.000 17.80315 ? 157 ARG A CA  1 
ATOM   1268 C C   . ARG A 1 157 ? -3.84568  -31.26336 28.44349  1.000 19.76747 ? 157 ARG A C   1 
ATOM   1269 O O   . ARG A 1 157 ? -4.25864  -30.10126 28.32918  1.000 17.19333 ? 157 ARG A O   1 
ATOM   1270 C CB  . ARG A 1 157 ? -4.39294  -32.37236 30.59224  1.000 22.48275 ? 157 ARG A CB  1 
ATOM   1271 C CG  . ARG A 1 157 ? -5.06969  -33.47736 31.35071  1.000 24.81624 ? 157 ARG A CG  1 
ATOM   1272 C CD  . ARG A 1 157 ? -6.23462  -32.98782 32.12573  1.000 28.77014 ? 157 ARG A CD  1 
ATOM   1273 N NE  . ARG A 1 157 ? -5.85899  -31.87271 32.98090  1.000 32.87933 ? 157 ARG A NE  1 
ATOM   1274 C CZ  . ARG A 1 157 ? -6.00562  -31.86768 34.29613  1.000 33.66650 ? 157 ARG A CZ  1 
ATOM   1275 N NH1 . ARG A 1 157 ? -6.36493  -32.95972 34.95129  1.000 34.03199 ? 157 ARG A NH1 1 
ATOM   1276 N NH2 . ARG A 1 157 ? -5.75438  -30.75021 34.97054  1.000 28.67428 ? 157 ARG A NH2 1 
ATOM   1277 N N   . ALA A 1 158 ? -2.61247  -31.62005 28.06577  1.000 15.29162 ? 158 ALA A N   1 
ATOM   1278 C CA  . ALA A 1 158 ? -1.74568  -30.61104 27.47470  1.000 18.88453 ? 158 ALA A CA  1 
ATOM   1279 C C   . ALA A 1 158 ? -2.38138  -30.02974 26.21946  1.000 16.10262 ? 158 ALA A C   1 
ATOM   1280 O O   . ALA A 1 158 ? -2.36602  -28.80925 26.02483  1.000 12.20917 ? 158 ALA A O   1 
ATOM   1281 C CB  . ALA A 1 158 ? -0.36899  -31.18843 27.16368  1.000 11.60623 ? 158 ALA A CB  1 
ATOM   1282 N N   . TYR A 1 159 ? -2.97077  -30.88348 25.37218  1.000 17.24822 ? 159 TYR A N   1 
ATOM   1283 C CA  . TYR A 1 159 ? -3.62504  -30.37299 24.17460  1.000 16.04515 ? 159 TYR A CA  1 
ATOM   1284 C C   . TYR A 1 159 ? -4.80045  -29.47629 24.54483  1.000 18.00913 ? 159 TYR A C   1 
ATOM   1285 O O   . TYR A 1 159 ? -4.88489  -28.31803 24.11395  1.000 17.05997 ? 159 TYR A O   1 
ATOM   1286 C CB  . TYR A 1 159 ? -4.10260  -31.51587 23.26551  1.000 17.85379 ? 159 TYR A CB  1 
ATOM   1287 C CG  . TYR A 1 159 ? -4.98389  -30.97952 22.15919  1.000 18.37970 ? 159 TYR A CG  1 
ATOM   1288 C CD1 . TYR A 1 159 ? -4.42211  -30.38721 21.03174  1.000 17.27045 ? 159 TYR A CD1 1 
ATOM   1289 C CD2 . TYR A 1 159 ? -6.37622  -31.01112 22.26220  1.000 17.83866 ? 159 TYR A CD2 1 
ATOM   1290 C CE1 . TYR A 1 159 ? -5.23103  -29.85363 20.01188  1.000 15.57822 ? 159 TYR A CE1 1 
ATOM   1291 C CE2 . TYR A 1 159 ? -7.18965  -30.49101 21.25157  1.000 19.13883 ? 159 TYR A CE2 1 
ATOM   1292 C CZ  . TYR A 1 159 ? -6.60897  -29.91125 20.12999  1.000 19.94858 ? 159 TYR A CZ  1 
ATOM   1293 O OH  . TYR A 1 159 ? -7.40873  -29.38809 19.13568  1.000 16.42347 ? 159 TYR A OH  1 
ATOM   1294 N N   . LEU A 1 160 ? -5.72186  -29.99991 25.35006  1.000 18.60189 ? 160 LEU A N   1 
ATOM   1295 C CA  . LEU A 1 160 ? -6.97675  -29.29505 25.59958  1.000 18.74046 ? 160 LEU A CA  1 
ATOM   1296 C C   . LEU A 1 160 ? -6.75351  -27.96865 26.29998  1.000 17.99106 ? 160 LEU A C   1 
ATOM   1297 O O   . LEU A 1 160 ? -7.39848  -26.96880 25.97146  1.000 20.85633 ? 160 LEU A O   1 
ATOM   1298 C CB  . LEU A 1 160 ? -7.91061  -30.17584 26.41839  1.000 18.16643 ? 160 LEU A CB  1 
ATOM   1299 C CG  . LEU A 1 160 ? -8.36659  -31.45666 25.74488  1.000 19.61355 ? 160 LEU A CG  1 
ATOM   1300 C CD1 . LEU A 1 160 ? -9.18814  -32.28496 26.73001  1.000 17.70812 ? 160 LEU A CD1 1 
ATOM   1301 C CD2 . LEU A 1 160 ? -9.19196  -31.13559 24.49892  1.000 17.79841 ? 160 LEU A CD2 1 
ATOM   1302 N N   . GLU A 1 161 ? -5.84717  -27.93443 27.26339  1.000 19.44669 ? 161 GLU A N   1 
ATOM   1303 C CA  . GLU A 1 161 ? -5.61980  -26.73252 28.05019  1.000 23.36918 ? 161 GLU A CA  1 
ATOM   1304 C C   . GLU A 1 161 ? -4.51951  -25.86115 27.47747  1.000 24.48076 ? 161 GLU A C   1 
ATOM   1305 O O   . GLU A 1 161 ? -4.40824  -24.69599 27.87823  1.000 25.77070 ? 161 GLU A O   1 
ATOM   1306 C CB  . GLU A 1 161 ? -5.27023  -27.12175 29.49506  1.000 22.48032 ? 161 GLU A CB  1 
ATOM   1307 C CG  . GLU A 1 161 ? -6.27367  -28.07443 30.13146  1.000 21.83269 ? 161 GLU A CG  1 
ATOM   1308 C CD  . GLU A 1 161 ? -6.16991  -28.10749 31.63719  1.000 32.73787 ? 161 GLU A CD  1 
ATOM   1309 O OE1 . GLU A 1 161 ? -5.97803  -27.03842 32.26309  1.000 35.16064 ? 161 GLU A OE1 1 
ATOM   1310 O OE2 . GLU A 1 161 ? -6.22814  -29.22629 32.19124  1.000 35.14982 ? 161 GLU A OE2 1 
ATOM   1311 N N   . GLY A 1 162 ? -3.71358  -26.39418 26.55171  1.000 21.51333 ? 162 GLY A N   1 
ATOM   1312 C CA  . GLY A 1 162 ? -2.59480  -25.66831 25.98473  1.000 17.03902 ? 162 GLY A CA  1 
ATOM   1313 C C   . GLY A 1 162 ? -2.71656  -25.40483 24.49688  1.000 17.57431 ? 162 GLY A C   1 
ATOM   1314 O O   . GLY A 1 162 ? -3.05164  -24.28633 24.10410  1.000 20.35371 ? 162 GLY A O   1 
ATOM   1315 N N   . THR A 1 163 ? -2.48408  -26.41739 23.65687  1.000 18.74904 ? 163 THR A N   1 
ATOM   1316 C CA  . THR A 1 163 ? -2.49635  -26.20211 22.20689  1.000 18.50298 ? 163 THR A CA  1 
ATOM   1317 C C   . THR A 1 163 ? -3.83655  -25.65174 21.73145  1.000 20.72534 ? 163 THR A C   1 
ATOM   1318 O O   . THR A 1 163 ? -3.89408  -24.70741 20.92505  1.000 15.76052 ? 163 THR A O   1 
ATOM   1319 C CB  . THR A 1 163 ? -2.19334  -27.50502 21.46588  1.000 19.22150 ? 163 THR A CB  1 
ATOM   1320 O OG1 . THR A 1 163 ? -1.01814  -28.11348 22.00532  1.000 21.21675 ? 163 THR A OG1 1 
ATOM   1321 C CG2 . THR A 1 163 ? -1.96390  -27.22608 19.99790  1.000 17.08775 ? 163 THR A CG2 1 
ATOM   1322 N N   . CYS A 1 164 ? -4.92696  -26.23927 22.21958  1.000 15.06148 ? 164 CYS A N   1 
ATOM   1323 C CA  . CYS A 1 164 ? -6.25296  -25.86212 21.74604  1.000 20.33262 ? 164 CYS A CA  1 
ATOM   1324 C C   . CYS A 1 164 ? -6.54408  -24.39648 22.04235  1.000 18.82631 ? 164 CYS A C   1 
ATOM   1325 O O   . CYS A 1 164 ? -6.91816  -23.63451 21.14217  1.000 19.88560 ? 164 CYS A O   1 
ATOM   1326 C CB  . CYS A 1 164 ? -7.29939  -26.78039 22.38254  1.000 20.16499 ? 164 CYS A CB  1 
ATOM   1327 S SG  . CYS A 1 164 ? -8.92089  -26.61219 21.72139  1.000 28.18902 ? 164 CYS A SG  1 
ATOM   1328 N N   . VAL A 1 165 ? -6.35247  -23.97257 23.29552  1.000 16.25950 ? 165 VAL A N   1 
ATOM   1329 C CA  . VAL A 1 165 ? -6.70597  -22.59762 23.63194  1.000 18.21574 ? 165 VAL A CA  1 
ATOM   1330 C C   . VAL A 1 165 ? -5.72344  -21.61843 22.99175  1.000 23.98173 ? 165 VAL A C   1 
ATOM   1331 O O   . VAL A 1 165 ? -6.10879  -20.49021 22.64734  1.000 23.04994 ? 165 VAL A O   1 
ATOM   1332 C CB  . VAL A 1 165 ? -6.79290  -22.39349 25.15640  1.000 25.32727 ? 165 VAL A CB  1 
ATOM   1333 C CG1 . VAL A 1 165 ? -7.49501  -23.57023 25.80983  1.000 28.49086 ? 165 VAL A CG1 1 
ATOM   1334 C CG2 . VAL A 1 165 ? -5.46258  -22.17113 25.75914  1.000 26.67119 ? 165 VAL A CG2 1 
ATOM   1335 N N   . ASP A 1 166 ? -4.45393  -22.02972 22.81847  1.000 19.80541 ? 166 ASP A N   1 
ATOM   1336 C CA  . ASP A 1 166 ? -3.46249  -21.20452 22.12676  1.000 21.54209 ? 166 ASP A CA  1 
ATOM   1337 C C   . ASP A 1 166 ? -3.82515  -21.04359 20.66210  1.000 19.37187 ? 166 ASP A C   1 
ATOM   1338 O O   . ASP A 1 166 ? -3.77766  -19.93441 20.11742  1.000 17.79731 ? 166 ASP A O   1 
ATOM   1339 C CB  . ASP A 1 166 ? -2.07680  -21.84031 22.23183  1.000 19.29599 ? 166 ASP A CB  1 
ATOM   1340 C CG  . ASP A 1 166 ? -1.51046  -21.81926 23.64115  1.000 25.24176 ? 166 ASP A CG  1 
ATOM   1341 O OD1 . ASP A 1 166 ? -2.06596  -21.12641 24.51793  1.000 25.66638 ? 166 ASP A OD1 1 
ATOM   1342 O OD2 . ASP A 1 166 ? -0.49865  -22.52451 23.86665  1.000 23.69824 ? 166 ASP A OD2 1 
ATOM   1343 N N   . GLY A 1 167 ? -4.17476  -22.15548 20.00137  1.000 19.42335 ? 167 GLY A N   1 
ATOM   1344 C CA  . GLY A 1 167 ? -4.62680  -22.07689 18.61946  1.000 17.46423 ? 167 GLY A CA  1 
ATOM   1345 C C   . GLY A 1 167 ? -5.85482  -21.19990 18.46914  1.000 17.89303 ? 167 GLY A C   1 
ATOM   1346 O O   . GLY A 1 167 ? -5.90256  -20.30859 17.61132  1.000 20.70075 ? 167 GLY A O   1 
ATOM   1347 N N   . LEU A 1 168 ? -6.86803  -21.44849 19.30333  1.000 15.99439 ? 168 LEU A N   1 
ATOM   1348 C CA  . LEU A 1 168 ? -8.09529  -20.65616 19.27810  1.000 16.76710 ? 168 LEU A CA  1 
ATOM   1349 C C   . LEU A 1 168 ? -7.80268  -19.17003 19.45165  1.000 18.13626 ? 168 LEU A C   1 
ATOM   1350 O O   . LEU A 1 168 ? -8.32745  -18.33478 18.70536  1.000 21.58748 ? 168 LEU A O   1 
ATOM   1351 C CB  . LEU A 1 168 ? -9.03245  -21.15012 20.37401  1.000 13.65108 ? 168 LEU A CB  1 
ATOM   1352 C CG  . LEU A 1 168 ? -10.36159 -20.41807 20.54632  1.000 19.49504 ? 168 LEU A CG  1 
ATOM   1353 C CD1 . LEU A 1 168 ? -11.08186 -20.22405 19.21136  1.000 15.11935 ? 168 LEU A CD1 1 
ATOM   1354 C CD2 . LEU A 1 168 ? -11.22696 -21.17600 21.56631  1.000 16.42803 ? 168 LEU A CD2 1 
ATOM   1355 N N   . ARG A 1 169 ? -6.96458  -18.82414 20.43607  1.000 18.14895 ? 169 ARG A N   1 
ATOM   1356 C CA  . ARG A 1 169 ? -6.52996  -17.43753 20.61984  1.000 22.72428 ? 169 ARG A CA  1 
ATOM   1357 C C   . ARG A 1 169 ? -5.90671  -16.87487 19.34334  1.000 18.68305 ? 169 ARG A C   1 
ATOM   1358 O O   . ARG A 1 169 ? -6.23745  -15.76226 18.90943  1.000 23.70345 ? 169 ARG A O   1 
ATOM   1359 C CB  . ARG A 1 169 ? -5.50699  -17.35190 21.75555  1.000 27.50611 ? 169 ARG A CB  1 
ATOM   1360 C CG  . ARG A 1 169 ? -6.01015  -17.44498 23.17387  1.000 33.96454 ? 169 ARG A CG  1 
ATOM   1361 C CD  . ARG A 1 169 ? -4.95932  -16.82729 24.10442  1.000 38.67372 ? 169 ARG A CD  1 
ATOM   1362 N NE  . ARG A 1 169 ? -5.43406  -16.73021 25.48007  1.000 45.65775 ? 169 ARG A NE  1 
ATOM   1363 C CZ  . ARG A 1 169 ? -5.09663  -17.58374 26.43857  1.000 44.74167 ? 169 ARG A CZ  1 
ATOM   1364 N NH1 . ARG A 1 169 ? -4.22243  -18.55536 26.22089  1.000 44.81946 ? 169 ARG A NH1 1 
ATOM   1365 N NH2 . ARG A 1 169 ? -5.64321  -17.45625 27.64633  1.000 41.03390 ? 169 ARG A NH2 1 
ATOM   1366 N N   . ARG A 1 170 ? -4.98197  -17.62326 18.73254  1.000 19.38661 ? 170 ARG A N   1 
ATOM   1367 C CA  . ARG A 1 170 ? -4.34872  -17.13649 17.51411  1.000 18.45760 ? 170 ARG A CA  1 
ATOM   1368 C C   . ARG A 1 170 ? -5.38163  -16.92139 16.41621  1.000 21.94287 ? 170 ARG A C   1 
ATOM   1369 O O   . ARG A 1 170 ? -5.37654  -15.88843 15.73651  1.000 22.44192 ? 170 ARG A O   1 
ATOM   1370 C CB  . ARG A 1 170 ? -3.25758  -18.10647 17.05375  1.000 19.17802 ? 170 ARG A CB  1 
ATOM   1371 C CG  . ARG A 1 170 ? -2.69165  -17.77614 15.66964  1.000 29.35103 ? 170 ARG A CG  1 
ATOM   1372 C CD  . ARG A 1 170 ? -1.53526  -18.71795 15.25190  1.000 34.92174 ? 170 ARG A CD  1 
ATOM   1373 N NE  . ARG A 1 170 ? -1.96280  -20.10814 15.13218  1.000 34.01901 ? 170 ARG A NE  1 
ATOM   1374 C CZ  . ARG A 1 170 ? -1.84725  -21.01569 16.09620  1.000 31.65389 ? 170 ARG A CZ  1 
ATOM   1375 N NH1 . ARG A 1 170 ? -1.25421  -20.73332 17.24820  1.000 33.76621 ? 170 ARG A NH1 1 
ATOM   1376 N NH2 . ARG A 1 170 ? -2.32666  -22.24044 15.89643  1.000 27.71470 ? 170 ARG A NH2 1 
ATOM   1377 N N   . TYR A 1 171 ? -6.28307  -17.88740 16.22519  1.000 18.45401 ? 171 TYR A N   1 
ATOM   1378 C CA  . TYR A 1 171 ? -7.27188  -17.73756 15.16789  1.000 21.24231 ? 171 TYR A CA  1 
ATOM   1379 C C   . TYR A 1 171 ? -8.14618  -16.51131 15.40667  1.000 18.85660 ? 171 TYR A C   1 
ATOM   1380 O O   . TYR A 1 171 ? -8.39714  -15.73753 14.47928  1.000 22.14863 ? 171 TYR A O   1 
ATOM   1381 C CB  . TYR A 1 171 ? -8.11460  -19.00535 15.03523  1.000 19.48337 ? 171 TYR A CB  1 
ATOM   1382 C CG  . TYR A 1 171 ? -7.29110  -20.25616 14.73576  1.000 19.09945 ? 171 TYR A CG  1 
ATOM   1383 C CD1 . TYR A 1 171 ? -6.15031  -20.20392 13.93377  1.000 19.46985 ? 171 TYR A CD1 1 
ATOM   1384 C CD2 . TYR A 1 171 ? -7.67466  -21.48568 15.24447  1.000 17.09971 ? 171 TYR A CD2 1 
ATOM   1385 C CE1 . TYR A 1 171 ? -5.39800  -21.37276 13.66947  1.000 23.78887 ? 171 TYR A CE1 1 
ATOM   1386 C CE2 . TYR A 1 171 ? -6.95320  -22.63809 14.98423  1.000 22.76401 ? 171 TYR A CE2 1 
ATOM   1387 C CZ  . TYR A 1 171 ? -5.81288  -22.58935 14.19877  1.000 20.64868 ? 171 TYR A CZ  1 
ATOM   1388 O OH  . TYR A 1 171 ? -5.10230  -23.78180 13.97186  1.000 15.55434 ? 171 TYR A OH  1 
ATOM   1389 N N   . LEU A 1 172 ? -8.58450  -16.29140 16.64755  1.000 20.66202 ? 172 LEU A N   1 
ATOM   1390 C CA  . LEU A 1 172 ? -9.44504  -15.14349 16.92320  1.000 26.50162 ? 172 LEU A CA  1 
ATOM   1391 C C   . LEU A 1 172 ? -8.72332  -13.82497 16.65060  1.000 27.54921 ? 172 LEU A C   1 
ATOM   1392 O O   . LEU A 1 172 ? -9.35136  -12.84620 16.23546  1.000 26.30115 ? 172 LEU A O   1 
ATOM   1393 C CB  . LEU A 1 172 ? -9.93041  -15.20152 18.36570  1.000 22.20368 ? 172 LEU A CB  1 
ATOM   1394 C CG  . LEU A 1 172 ? -10.88742 -16.34243 18.72127  1.000 20.33288 ? 172 LEU A CG  1 
ATOM   1395 C CD1 . LEU A 1 172 ? -10.90547 -16.52950 20.22390  1.000 23.94849 ? 172 LEU A CD1 1 
ATOM   1396 C CD2 . LEU A 1 172 ? -12.29298 -16.08311 18.18562  1.000 22.20951 ? 172 LEU A CD2 1 
ATOM   1397 N N   . GLU A 1 173 ? -7.40384  -13.78478 16.85812  1.000 27.54925 ? 173 GLU A N   1 
ATOM   1398 C CA  . GLU A 1 173 ? -6.63625  -12.59681 16.49666  1.000 28.48240 ? 173 GLU A CA  1 
ATOM   1399 C C   . GLU A 1 173 ? -6.45515  -12.49415 14.98349  1.000 28.54051 ? 173 GLU A C   1 
ATOM   1400 O O   . GLU A 1 173 ? -6.66004  -11.42876 14.39876  1.000 34.18743 ? 173 GLU A O   1 
ATOM   1401 C CB  . GLU A 1 173 ? -5.28781  -12.60955 17.22033  1.000 28.62006 ? 173 GLU A CB  1 
ATOM   1402 C CG  . GLU A 1 173 ? -4.33805  -11.47141 16.84073  1.000 38.39637 ? 173 GLU A CG  1 
ATOM   1403 C CD  . GLU A 1 173 ? -4.85340  -10.08581 17.22689  1.000 50.65857 ? 173 GLU A CD  1 
ATOM   1404 O OE1 . GLU A 1 173 ? -5.81927  -9.98959  18.01487  1.000 54.03426 ? 173 GLU A OE1 1 
ATOM   1405 O OE2 . GLU A 1 173 ? -4.27402  -9.08009  16.73614  1.000 54.69845 ? 173 GLU A OE2 1 
ATOM   1406 N N   . ASN A 1 174 ? -6.08834  -13.59415 14.32196  1.000 27.69006 ? 174 ASN A N   1 
ATOM   1407 C CA  . ASN A 1 174 ? -5.88993  -13.53501 12.87567  1.000 23.56504 ? 174 ASN A CA  1 
ATOM   1408 C C   . ASN A 1 174 ? -7.18497  -13.22341 12.13584  1.000 29.36285 ? 174 ASN A C   1 
ATOM   1409 O O   . ASN A 1 174 ? -7.16748  -12.54016 11.10583  1.000 31.97292 ? 174 ASN A O   1 
ATOM   1410 C CB  . ASN A 1 174 ? -5.29621  -14.84735 12.36778  1.000 26.13275 ? 174 ASN A CB  1 
ATOM   1411 C CG  . ASN A 1 174 ? -3.82756  -15.02329 12.77376  1.000 31.05005 ? 174 ASN A CG  1 
ATOM   1412 O OD1 . ASN A 1 174 ? -3.20312  -14.09900 13.29679  1.000 33.42389 ? 174 ASN A OD1 1 
ATOM   1413 N ND2 . ASN A 1 174 ? -3.28192  -16.21459 12.54229  1.000 32.87981 ? 174 ASN A ND2 1 
ATOM   1414 N N   . GLY A 1 175 ? -8.31002  -13.71898 12.62456  1.000 29.64167 ? 175 GLY A N   1 
ATOM   1415 C CA  . GLY A 1 175 ? -9.56197  -13.44538 11.95144  1.000 26.11387 ? 175 GLY A CA  1 
ATOM   1416 C C   . GLY A 1 175 ? -10.47302 -12.49468 12.69287  1.000 29.79297 ? 175 GLY A C   1 
ATOM   1417 O O   . GLY A 1 175 ? -11.68836 -12.68421 12.61130  1.000 32.70746 ? 175 GLY A O   1 
ATOM   1418 N N   . LYS A 1 176 ? -9.93584  -11.48377 13.40731  1.000 27.32891 ? 176 LYS A N   1 
ATOM   1419 C CA  . LYS A 1 176 ? -10.80302 -10.61097 14.20299  1.000 34.19654 ? 176 LYS A CA  1 
ATOM   1420 C C   . LYS A 1 176 ? -11.96219 -10.09208 13.37505  1.000 35.66215 ? 176 LYS A C   1 
ATOM   1421 O O   . LYS A 1 176 ? -13.10238 -10.04972 13.85277  1.000 36.69286 ? 176 LYS A O   1 
ATOM   1422 C CB  . LYS A 1 176 ? -10.08418 -9.38214  14.77431  1.000 37.77721 ? 176 LYS A CB  1 
ATOM   1423 C CG  . LYS A 1 176 ? -8.61524  -9.41483  14.93720  1.000 38.99090 ? 176 LYS A CG  1 
ATOM   1424 C CD  . LYS A 1 176 ? -8.07880  -8.00690  15.19483  1.000 43.00688 ? 176 LYS A CD  1 
ATOM   1425 C CE  . LYS A 1 176 ? -8.36187  -7.56871  16.63360  1.000 45.87826 ? 176 LYS A CE  1 
ATOM   1426 N NZ  . LYS A 1 176 ? -8.34986  -6.08334  16.81309  1.000 55.27608 ? 176 LYS A NZ  1 
ATOM   1427 N N   . GLU A 1 177 ? -11.67728 -9.67118  12.13401  1.000 36.57405 ? 177 GLU A N   1 
ATOM   1428 C CA  . GLU A 1 177 ? -12.68371 -8.99102  11.32532  1.000 38.81823 ? 177 GLU A CA  1 
ATOM   1429 C C   . GLU A 1 177 ? -13.88079 -9.89430  11.07685  1.000 36.82592 ? 177 GLU A C   1 
ATOM   1430 O O   . GLU A 1 177 ? -15.02577 -9.43224  11.06585  1.000 47.00403 ? 177 GLU A O   1 
ATOM   1431 C CB  . GLU A 1 177 ? -12.07062 -8.53507  10.00063  1.000 39.64788 ? 177 GLU A CB  1 
ATOM   1432 C CG  . GLU A 1 177 ? -10.94512 -7.53022  10.16465  1.000 46.81094 ? 177 GLU A CG  1 
ATOM   1433 C CD  . GLU A 1 177 ? -11.30688 -6.40114  11.10698  1.000 55.81264 ? 177 GLU A CD  1 
ATOM   1434 O OE1 . GLU A 1 177 ? -12.33860 -5.73468  10.86086  1.000 64.60399 ? 177 GLU A OE1 1 
ATOM   1435 O OE2 . GLU A 1 177 ? -10.57213 -6.18723  12.10066  1.000 54.30023 ? 177 GLU A OE2 1 
ATOM   1436 N N   . THR A 1 178 ? -13.63291 -11.18832 10.88802  1.000 40.15874 ? 178 THR A N   1 
ATOM   1437 C CA  . THR A 1 178 ? -14.67189 -12.17620 10.63040  1.000 36.24011 ? 178 THR A CA  1 
ATOM   1438 C C   . THR A 1 178 ? -15.23257 -12.74726 11.93078  1.000 32.67224 ? 178 THR A C   1 
ATOM   1439 O O   . THR A 1 178 ? -16.44904 -12.74664 12.14143  1.000 36.06151 ? 178 THR A O   1 
ATOM   1440 C CB  . THR A 1 178 ? -14.09902 -13.29867 9.74982   1.000 33.28729 ? 178 THR A CB  1 
ATOM   1441 O OG1 . THR A 1 178 ? -14.10641 -12.88220 8.38053   1.000 44.78828 ? 178 THR A OG1 1 
ATOM   1442 C CG2 . THR A 1 178 ? -14.92265 -14.58600 9.86682   1.000 32.50431 ? 178 THR A CG2 1 
ATOM   1443 N N   . LEU A 1 179 ? -14.35269 -13.20267 12.82556  1.000 29.65730 ? 179 LEU A N   1 
ATOM   1444 C CA  . LEU A 1 179 ? -14.76290 -13.99066 13.98584  1.000 28.33296 ? 179 LEU A CA  1 
ATOM   1445 C C   . LEU A 1 179 ? -15.25026 -13.14339 15.15025  1.000 30.89367 ? 179 LEU A C   1 
ATOM   1446 O O   . LEU A 1 179 ? -16.10450 -13.59552 15.91374  1.000 25.90323 ? 179 LEU A O   1 
ATOM   1447 C CB  . LEU A 1 179 ? -13.59873 -14.86082 14.45941  1.000 26.02710 ? 179 LEU A CB  1 
ATOM   1448 C CG  . LEU A 1 179 ? -13.12887 -15.88908 13.42976  1.000 26.19990 ? 179 LEU A CG  1 
ATOM   1449 C CD1 . LEU A 1 179 ? -11.78762 -16.50939 13.80201  1.000 22.79500 ? 179 LEU A CD1 1 
ATOM   1450 C CD2 . LEU A 1 179 ? -14.19673 -16.95550 13.28465  1.000 23.84007 ? 179 LEU A CD2 1 
ATOM   1451 N N   . GLN A 1 180 ? -14.70173 -11.94801 15.34188  1.000 29.09326 ? 180 GLN A N   1 
ATOM   1452 C CA  . GLN A 1 180 ? -15.04255 -11.14075 16.50063  1.000 32.20292 ? 180 GLN A CA  1 
ATOM   1453 C C   . GLN A 1 180 ? -16.12406 -10.11474 16.20890  1.000 35.50923 ? 180 GLN A C   1 
ATOM   1454 O O   . GLN A 1 180 ? -16.39248 -9.25617  17.05405  1.000 44.07780 ? 180 GLN A O   1 
ATOM   1455 C CB  . GLN A 1 180 ? -13.78818 -10.46974 17.04781  1.000 32.41723 ? 180 GLN A CB  1 
ATOM   1456 C CG  . GLN A 1 180 ? -12.78669 -11.49767 17.48693  1.000 33.69558 ? 180 GLN A CG  1 
ATOM   1457 C CD  . GLN A 1 180 ? -11.84089 -10.98979 18.54229  1.000 37.81555 ? 180 GLN A CD  1 
ATOM   1458 O OE1 . GLN A 1 180 ? -12.25922 -10.57268 19.62668  1.000 37.02418 ? 180 GLN A OE1 1 
ATOM   1459 N NE2 . GLN A 1 180 ? -10.54342 -11.04946 18.24199  1.000 32.26113 ? 180 GLN A NE2 1 
ATOM   1460 N N   . ARG A 1 181 ? -16.76632 -10.19479 15.05067  1.000 31.52677 ? 181 ARG A N   1 
ATOM   1461 C CA  . ARG A 1 181 ? -17.85620 -9.28501  14.74953  1.000 34.40133 ? 181 ARG A CA  1 
ATOM   1462 C C   . ARG A 1 181 ? -19.17370 -9.96679  15.12753  1.000 33.01212 ? 181 ARG A C   1 
ATOM   1463 O O   . ARG A 1 181 ? -19.25198 -11.19156 15.25855  1.000 34.64205 ? 181 ARG A O   1 
ATOM   1464 C CB  . ARG A 1 181 ? -17.82399 -8.89381  13.26451  1.000 38.93176 ? 181 ARG A CB  1 
ATOM   1465 C CG  . ARG A 1 181 ? -18.20635 -7.42107  12.90545  1.000 45.26387 ? 181 ARG A CG  1 
ATOM   1466 C CD  . ARG A 1 181 ? -19.47361 -6.91329  13.59790  1.000 44.87687 ? 181 ARG A CD  1 
ATOM   1467 N NE  . ARG A 1 181 ? -19.99527 -5.64782  13.07976  1.000 57.66444 ? 181 ARG A NE  1 
ATOM   1468 C CZ  . ARG A 1 181 ? -20.96726 -4.94396  13.65335  1.000 57.25814 ? 181 ARG A CZ  1 
ATOM   1469 N NH1 . ARG A 1 181 ? -21.53713 -5.34109  14.78168  1.000 48.57180 ? 181 ARG A NH1 1 
ATOM   1470 N NH2 . ARG A 1 181 ? -21.39328 -3.82439  13.06944  1.000 55.82297 ? 181 ARG A NH2 1 
ATOM   1471 N N   . THR A 1 182 ? -20.18280 -9.14918  15.39730  1.000 33.16832 ? 182 THR A N   1 
ATOM   1472 C CA  . THR A 1 182 ? -21.56504 -9.58586  15.52216  1.000 31.87140 ? 182 THR A CA  1 
ATOM   1473 C C   . THR A 1 182 ? -22.36654 -8.91959  14.41386  1.000 34.40990 ? 182 THR A C   1 
ATOM   1474 O O   . THR A 1 182 ? -22.26005 -7.70671  14.21025  1.000 33.35611 ? 182 THR A O   1 
ATOM   1475 C CB  . THR A 1 182 ? -22.14303 -9.23009  16.89219  1.000 28.70732 ? 182 THR A CB  1 
ATOM   1476 O OG1 . THR A 1 182 ? -22.18635 -7.80383  17.02603  1.000 37.50871 ? 182 THR A OG1 1 
ATOM   1477 C CG2 . THR A 1 182 ? -21.29109 -9.82012  18.01872  1.000 30.56219 ? 182 THR A CG2 1 
ATOM   1478 N N   . ASP A 1 183 ? -23.13679 -9.71271  13.67862  1.000 30.55894 ? 183 ASP A N   1 
ATOM   1479 C CA  . ASP A 1 183 ? -24.02619 -9.16668  12.66557  1.000 23.05687 ? 183 ASP A CA  1 
ATOM   1480 C C   . ASP A 1 183 ? -25.43754 -9.27278  13.22247  1.000 26.07837 ? 183 ASP A C   1 
ATOM   1481 O O   . ASP A 1 183 ? -25.90696 -10.39489 13.49478  1.000 17.17318 ? 183 ASP A O   1 
ATOM   1482 C CB  . ASP A 1 183 ? -23.90380 -9.93530  11.35527  1.000 25.09743 ? 183 ASP A CB  1 
ATOM   1483 C CG  . ASP A 1 183 ? -22.66189 -9.55444  10.57348  1.000 42.31836 ? 183 ASP A CG  1 
ATOM   1484 O OD1 . ASP A 1 183 ? -22.16705 -8.41532  10.74648  1.000 41.94926 ? 183 ASP A OD1 1 
ATOM   1485 O OD2 . ASP A 1 183 ? -22.17878 -10.39968 9.78496   1.000 40.34372 ? 183 ASP A OD2 1 
ATOM   1486 N N   . PRO A 1 184 ? -26.11365 -8.15195  13.48872  1.000 26.94489 ? 184 PRO A N   1 
ATOM   1487 C CA  . PRO A 1 184 ? -27.44841 -8.23676  14.07057  1.000 22.64261 ? 184 PRO A CA  1 
ATOM   1488 C C   . PRO A 1 184 ? -28.45873 -8.71063  13.04769  1.000 22.03862 ? 184 PRO A C   1 
ATOM   1489 O O   . PRO A 1 184 ? -28.27892 -8.51030  11.83490  1.000 19.84295 ? 184 PRO A O   1 
ATOM   1490 C CB  . PRO A 1 184 ? -27.71799 -6.78767  14.51539  1.000 25.97747 ? 184 PRO A CB  1 
ATOM   1491 C CG  . PRO A 1 184 ? -26.92813 -6.00453  13.50948  1.000 25.29767 ? 184 PRO A CG  1 
ATOM   1492 C CD  . PRO A 1 184 ? -25.62102 -6.76895  13.55732  1.000 27.48220 ? 184 PRO A CD  1 
ATOM   1493 N N   . PRO A 1 185 ? -29.52946 -9.37834  13.48002  1.000 20.17376 ? 185 PRO A N   1 
ATOM   1494 C CA  . PRO A 1 185 ? -30.51893 -9.85460  12.50495  1.000 17.21847 ? 185 PRO A CA  1 
ATOM   1495 C C   . PRO A 1 185 ? -31.26836 -8.69659  11.86894  1.000 17.96568 ? 185 PRO A C   1 
ATOM   1496 O O   . PRO A 1 185 ? -31.62680 -7.71729  12.53484  1.000 17.52787 ? 185 PRO A O   1 
ATOM   1497 C CB  . PRO A 1 185 ? -31.44519 -10.74456 13.33254  1.000 14.81590 ? 185 PRO A CB  1 
ATOM   1498 C CG  . PRO A 1 185 ? -31.26298 -10.28440 14.75378  1.000 24.73816 ? 185 PRO A CG  1 
ATOM   1499 C CD  . PRO A 1 185 ? -29.85657 -9.77514  14.86190  1.000 18.55687 ? 185 PRO A CD  1 
ATOM   1500 N N   . LYS A 1 186 ? -31.46271 -8.80947  10.55997  1.000 16.96423 ? 186 LYS A N   1 
ATOM   1501 C CA  . LYS A 1 186 ? -32.42470 -7.99519  9.82440   1.000 19.46845 ? 186 LYS A CA  1 
ATOM   1502 C C   . LYS A 1 186 ? -33.77276 -8.69258  9.90021   1.000 18.96175 ? 186 LYS A C   1 
ATOM   1503 O O   . LYS A 1 186 ? -33.89778 -9.83896  9.46670   1.000 20.34913 ? 186 LYS A O   1 
ATOM   1504 C CB  . LYS A 1 186 ? -32.04241 -7.81011  8.35278   1.000 21.36520 ? 186 LYS A CB  1 
ATOM   1505 C CG  . LYS A 1 186 ? -30.96351 -6.77288  8.00431   1.000 30.84311 ? 186 LYS A CG  1 
ATOM   1506 C CD  . LYS A 1 186 ? -29.78228 -6.67549  8.95760   1.000 30.00345 ? 186 LYS A CD  1 
ATOM   1507 C CE  . LYS A 1 186 ? -28.83487 -7.86435  8.81632   1.000 30.71724 ? 186 LYS A CE  1 
ATOM   1508 N NZ  . LYS A 1 186 ? -27.54905 -7.71100  9.62819   1.000 28.28667 ? 186 LYS A NZ  1 
ATOM   1509 N N   . THR A 1 187 ? -34.78139 -7.99762  10.41917  1.000 19.86087 ? 187 THR A N   1 
ATOM   1510 C CA  . THR A 1 187 ? -36.05723 -8.61475  10.74209  1.000 20.34490 ? 187 THR A CA  1 
ATOM   1511 C C   . THR A 1 187 ? -37.18323 -8.00077  9.93126   1.000 17.52570 ? 187 THR A C   1 
ATOM   1512 O O   . THR A 1 187 ? -37.16024 -6.81286  9.60298   1.000 15.23818 ? 187 THR A O   1 
ATOM   1513 C CB  . THR A 1 187 ? -36.39683 -8.46999  12.22842  1.000 21.22708 ? 187 THR A CB  1 
ATOM   1514 O OG1 . THR A 1 187 ? -36.50445 -7.07560  12.55530  1.000 18.50534 ? 187 THR A OG1 1 
ATOM   1515 C CG2 . THR A 1 187 ? -35.32486 -9.13582  13.08279  1.000 15.94198 ? 187 THR A CG2 1 
ATOM   1516 N N   . HIS A 1 188 ? -38.17197 -8.83603  9.62188   1.000 19.59820 ? 188 HIS A N   1 
ATOM   1517 C CA  . HIS A 1 188 ? -39.41410 -8.39298  9.00812   1.000 17.97687 ? 188 HIS A CA  1 
ATOM   1518 C C   . HIS A 1 188 ? -40.47750 -9.43163  9.30540   1.000 18.97291 ? 188 HIS A C   1 
ATOM   1519 O O   . HIS A 1 188 ? -40.18137 -10.54122 9.74814   1.000 17.24052 ? 188 HIS A O   1 
ATOM   1520 C CB  . HIS A 1 188 ? -39.27285 -8.18419  7.49367   1.000 16.48862 ? 188 HIS A CB  1 
ATOM   1521 C CG  . HIS A 1 188 ? -39.18637 -9.44925  6.68560   1.000 17.02578 ? 188 HIS A CG  1 
ATOM   1522 N ND1 . HIS A 1 188 ? -38.00049 -10.11225 6.45988   1.000 19.28771 ? 188 HIS A ND1 1 
ATOM   1523 C CD2 . HIS A 1 188 ? -40.12931 -10.12398 5.98688   1.000 20.54231 ? 188 HIS A CD2 1 
ATOM   1524 C CE1 . HIS A 1 188 ? -38.22157 -11.16387 5.68948   1.000 16.48048 ? 188 HIS A CE1 1 
ATOM   1525 N NE2 . HIS A 1 188 ? -39.50546 -11.18841 5.37818   1.000 19.18319 ? 188 HIS A NE2 1 
ATOM   1526 N N   . MET A 1 189 ? -41.72115 -9.06751  9.02701   1.000 15.66958 ? 189 MET A N   1 
ATOM   1527 C CA  . MET A 1 189 ? -42.84576 -9.96169  9.22755   1.000 19.14564 ? 189 MET A CA  1 
ATOM   1528 C C   . MET A 1 189 ? -43.63484 -10.09508 7.93688   1.000 20.69976 ? 189 MET A C   1 
ATOM   1529 O O   . MET A 1 189 ? -43.74565 -9.13883  7.16301   1.000 16.77732 ? 189 MET A O   1 
ATOM   1530 C CB  . MET A 1 189 ? -43.72711 -9.43697  10.37952  1.000 17.92159 ? 189 MET A CB  1 
ATOM   1531 C CG  . MET A 1 189 ? -44.20908 -10.53281 11.30934  1.000 22.73538 ? 189 MET A CG  1 
ATOM   1532 S SD  . MET A 1 189 ? -45.62873 -10.00797 12.23956  1.000 44.28145 ? 189 MET A SD  1 
ATOM   1533 C CE  . MET A 1 189 ? -44.85177 -8.58517  12.97344  1.000 24.93732 ? 189 MET A CE  1 
ATOM   1534 N N   . THR A 1 190 ? -44.15927 -11.29615 7.69741   1.000 16.89478 ? 190 THR A N   1 
ATOM   1535 C CA  . THR A 1 190 ? -45.05318 -11.55830 6.58799   1.000 18.57824 ? 190 THR A CA  1 
ATOM   1536 C C   . THR A 1 190 ? -46.41285 -12.01109 7.11816   1.000 19.35598 ? 190 THR A C   1 
ATOM   1537 O O   . THR A 1 190 ? -46.55198 -12.42617 8.27403   1.000 14.00788 ? 190 THR A O   1 
ATOM   1538 C CB  . THR A 1 190 ? -44.45092 -12.59041 5.62646   1.000 21.20273 ? 190 THR A CB  1 
ATOM   1539 O OG1 . THR A 1 190 ? -44.47865 -13.89359 6.22686   1.000 18.13102 ? 190 THR A OG1 1 
ATOM   1540 C CG2 . THR A 1 190 ? -43.01135 -12.20355 5.28404   1.000 19.70346 ? 190 THR A CG2 1 
ATOM   1541 N N   . HIS A 1 191 ? -47.42632 -11.86537 6.26759   1.000 17.66179 ? 191 HIS A N   1 
ATOM   1542 C CA  . HIS A 1 191 ? -48.82629 -12.04104 6.65413   1.000 19.95301 ? 191 HIS A CA  1 
ATOM   1543 C C   . HIS A 1 191 ? -49.54031 -12.72837 5.50614   1.000 20.85674 ? 191 HIS A C   1 
ATOM   1544 O O   . HIS A 1 191 ? -49.55877 -12.18800 4.39612   1.000 20.11013 ? 191 HIS A O   1 
ATOM   1545 C CB  . HIS A 1 191 ? -49.48780 -10.68568 6.92534   1.000 20.09487 ? 191 HIS A CB  1 
ATOM   1546 C CG  . HIS A 1 191 ? -50.90176 -10.77377 7.40521   1.000 18.87335 ? 191 HIS A CG  1 
ATOM   1547 N ND1 . HIS A 1 191 ? -51.85854 -9.85748  7.02822   1.000 21.35776 ? 191 HIS A ND1 1 
ATOM   1548 C CD2 . HIS A 1 191 ? -51.50175 -11.60053 8.29429   1.000 20.27470 ? 191 HIS A CD2 1 
ATOM   1549 C CE1 . HIS A 1 191 ? -53.00278 -10.14766 7.62119   1.000 24.11535 ? 191 HIS A CE1 1 
ATOM   1550 N NE2 . HIS A 1 191 ? -52.81522 -11.20018 8.39623   1.000 20.69142 ? 191 HIS A NE2 1 
ATOM   1551 N N   . HIS A 1 192 ? -50.12139 -13.90154 5.75130   1.000 14.97801 ? 192 HIS A N   1 
ATOM   1552 C CA  . HIS A 1 192 ? -50.87594 -14.60543 4.71713   1.000 18.42262 ? 192 HIS A CA  1 
ATOM   1553 C C   . HIS A 1 192 ? -52.20321 -15.11568 5.26513   1.000 22.20333 ? 192 HIS A C   1 
ATOM   1554 O O   . HIS A 1 192 ? -52.20902 -15.96669 6.17277   1.000 20.04030 ? 192 HIS A O   1 
ATOM   1555 C CB  . HIS A 1 192 ? -50.06741 -15.76275 4.12130   1.000 22.74880 ? 192 HIS A CB  1 
ATOM   1556 C CG  . HIS A 1 192 ? -48.69013 -15.37019 3.67023   1.000 19.05235 ? 192 HIS A CG  1 
ATOM   1557 N ND1 . HIS A 1 192 ? -48.47318 -14.55276 2.57976   1.000 26.81175 ? 192 HIS A ND1 1 
ATOM   1558 C CD2 . HIS A 1 192 ? -47.46187 -15.69499 4.14640   1.000 29.65804 ? 192 HIS A CD2 1 
ATOM   1559 C CE1 . HIS A 1 192 ? -47.17074 -14.38059 2.40919   1.000 21.77557 ? 192 HIS A CE1 1 
ATOM   1560 N NE2 . HIS A 1 192 ? -46.53401 -15.06503 3.34599   1.000 25.26556 ? 192 HIS A NE2 1 
ATOM   1561 N N   . PRO A 1 193 ? -53.33233 -14.65327 4.74691   1.000 24.85386 ? 193 PRO A N   1 
ATOM   1562 C CA  . PRO A 1 193 ? -54.60921 -15.31293 5.06335   1.000 24.72688 ? 193 PRO A CA  1 
ATOM   1563 C C   . PRO A 1 193 ? -54.59538 -16.76336 4.59622   1.000 26.88882 ? 193 PRO A C   1 
ATOM   1564 O O   . PRO A 1 193 ? -54.08407 -17.07855 3.51890   1.000 25.88382 ? 193 PRO A O   1 
ATOM   1565 C CB  . PRO A 1 193 ? -55.63691 -14.47475 4.29234   1.000 28.40103 ? 193 PRO A CB  1 
ATOM   1566 C CG  . PRO A 1 193 ? -54.83091 -13.77664 3.21394   1.000 30.34918 ? 193 PRO A CG  1 
ATOM   1567 C CD  . PRO A 1 193 ? -53.50464 -13.48762 3.86157   1.000 22.46000 ? 193 PRO A CD  1 
ATOM   1568 N N   . ILE A 1 194 ? -55.12303 -17.65907 5.43191   1.000 27.48487 ? 194 ILE A N   1 
ATOM   1569 C CA  . ILE A 1 194 ? -55.23949 -19.06919 5.06725   1.000 29.79567 ? 194 ILE A CA  1 
ATOM   1570 C C   . ILE A 1 194 ? -56.68298 -19.52337 4.96914   1.000 33.16588 ? 194 ILE A C   1 
ATOM   1571 O O   . ILE A 1 194 ? -56.93397 -20.64331 4.49945   1.000 30.78958 ? 194 ILE A O   1 
ATOM   1572 C CB  . ILE A 1 194 ? -54.46690 -19.98914 6.03617   1.000 30.59376 ? 194 ILE A CB  1 
ATOM   1573 C CG1 . ILE A 1 194 ? -54.84866 -19.69505 7.48598   1.000 31.92427 ? 194 ILE A CG1 1 
ATOM   1574 C CG2 . ILE A 1 194 ? -52.94607 -19.86145 5.82092   1.000 30.19450 ? 194 ILE A CG2 1 
ATOM   1575 C CD1 . ILE A 1 194 ? -54.36302 -20.76378 8.45165   1.000 30.48712 ? 194 ILE A CD1 1 
ATOM   1576 N N   . SER A 1 195 ? -57.62300 -18.71023 5.42660   1.000 30.96061 ? 195 SER A N   1 
ATOM   1577 C CA  . SER A 1 195 ? -59.03901 -18.81697 5.10432   1.000 37.14419 ? 195 SER A CA  1 
ATOM   1578 C C   . SER A 1 195 ? -59.66439 -17.48835 5.49654   1.000 39.27219 ? 195 SER A C   1 
ATOM   1579 O O   . SER A 1 195 ? -58.96163 -16.52275 5.81617   1.000 38.68353 ? 195 SER A O   1 
ATOM   1580 C CB  . SER A 1 195 ? -59.71166 -20.00367 5.80905   1.000 33.67666 ? 195 SER A CB  1 
ATOM   1581 O OG  . SER A 1 195 ? -59.50574 -19.97975 7.21128   1.000 36.00993 ? 195 SER A OG  1 
ATOM   1582 N N   . ASP A 1 196 ? -60.98770 -17.43034 5.48147   1.000 41.37228 ? 196 ASP A N   1 
ATOM   1583 C CA  . ASP A 1 196 ? -61.63850 -16.21945 5.95189   1.000 45.89655 ? 196 ASP A CA  1 
ATOM   1584 C C   . ASP A 1 196 ? -61.66184 -16.11360 7.47251   1.000 42.65298 ? 196 ASP A C   1 
ATOM   1585 O O   . ASP A 1 196 ? -62.01710 -15.05249 7.99038   1.000 47.24748 ? 196 ASP A O   1 
ATOM   1586 C CB  . ASP A 1 196 ? -63.04930 -16.14618 5.36870   1.000 48.57039 ? 196 ASP A CB  1 
ATOM   1587 C CG  . ASP A 1 196 ? -63.83013 -17.42934 5.58061   1.000 56.26235 ? 196 ASP A CG  1 
ATOM   1588 O OD1 . ASP A 1 196 ? -63.19172 -18.47940 5.82343   1.000 53.84125 ? 196 ASP A OD1 1 
ATOM   1589 O OD2 . ASP A 1 196 ? -65.07885 -17.39521 5.48961   1.000 63.60957 ? 196 ASP A OD2 1 
ATOM   1590 N N   . HIS A 1 197 ? -61.27040 -17.16734 8.19343   1.000 36.89162 ? 197 HIS A N   1 
ATOM   1591 C CA  . HIS A 1 197 ? -61.23800 -17.14871 9.65340   1.000 37.25589 ? 197 HIS A CA  1 
ATOM   1592 C C   . HIS A 1 197 ? -59.84761 -16.93358 10.23147  1.000 35.23611 ? 197 HIS A C   1 
ATOM   1593 O O   . HIS A 1 197 ? -59.73597 -16.44581 11.36127  1.000 28.89737 ? 197 HIS A O   1 
ATOM   1594 C CB  . HIS A 1 197 ? -61.76908 -18.46378 10.24299  1.000 36.80825 ? 197 HIS A CB  1 
ATOM   1595 C CG  . HIS A 1 197 ? -62.94364 -19.04403 9.52088   1.000 53.73733 ? 197 HIS A CG  1 
ATOM   1596 N ND1 . HIS A 1 197 ? -63.79730 -18.29075 8.74048   1.000 58.96973 ? 197 HIS A ND1 1 
ATOM   1597 C CD2 . HIS A 1 197 ? -63.40189 -20.31797 9.45673   1.000 59.42863 ? 197 HIS A CD2 1 
ATOM   1598 C CE1 . HIS A 1 197 ? -64.73815 -19.07289 8.23891   1.000 62.14459 ? 197 HIS A CE1 1 
ATOM   1599 N NE2 . HIS A 1 197 ? -64.51891 -20.30820 8.65491   1.000 66.53656 ? 197 HIS A NE2 1 
ATOM   1600 N N   . GLU A 1 198 ? -58.78707 -17.32915 9.52112   1.000 31.06238 ? 198 GLU A N   1 
ATOM   1601 C CA  . GLU A 1 198 ? -57.45905 -17.35679 10.11498  1.000 26.60255 ? 198 GLU A CA  1 
ATOM   1602 C C   . GLU A 1 198 ? -56.41809 -16.80465 9.15368   1.000 27.31091 ? 198 GLU A C   1 
ATOM   1603 O O   . GLU A 1 198 ? -56.64067 -16.70260 7.94369   1.000 18.03822 ? 198 GLU A O   1 
ATOM   1604 C CB  . GLU A 1 198 ? -57.05449 -18.77063 10.53567  1.000 30.56882 ? 198 GLU A CB  1 
ATOM   1605 C CG  . GLU A 1 198 ? -57.97729 -19.39361 11.56477  1.000 32.04608 ? 198 GLU A CG  1 
ATOM   1606 C CD  . GLU A 1 198 ? -57.45489 -20.71840 12.06890  1.000 37.61008 ? 198 GLU A CD  1 
ATOM   1607 O OE1 . GLU A 1 198 ? -57.16493 -21.60003 11.22049  1.000 37.53482 ? 198 GLU A OE1 1 
ATOM   1608 O OE2 . GLU A 1 198 ? -57.33417 -20.87102 13.30924  1.000 38.21008 ? 198 GLU A OE2 1 
ATOM   1609 N N   . ALA A 1 199 ? -55.26072 -16.46106 9.72380   1.000 21.65672 ? 199 ALA A N   1 
ATOM   1610 C CA  . ALA A 1 199 ? -54.12417 -15.97402 8.95760   1.000 21.84931 ? 199 ALA A CA  1 
ATOM   1611 C C   . ALA A 1 199 ? -52.83935 -16.48205 9.59283   1.000 21.70758 ? 199 ALA A C   1 
ATOM   1612 O O   . ALA A 1 199 ? -52.79321 -16.74353 10.79421  1.000 21.26360 ? 199 ALA A O   1 
ATOM   1613 C CB  . ALA A 1 199 ? -54.09841 -14.43986 8.89221   1.000 19.35055 ? 199 ALA A CB  1 
ATOM   1614 N N   . THR A 1 200 ? -51.79667 -16.62003 8.77572   1.000 15.43857 ? 200 THR A N   1 
ATOM   1615 C CA  . THR A 1 200 ? -50.45890 -16.93379 9.25556   1.000 14.01946 ? 200 THR A CA  1 
ATOM   1616 C C   . THR A 1 200 ? -49.68244 -15.63021 9.39357   1.000 16.79460 ? 200 THR A C   1 
ATOM   1617 O O   . THR A 1 200 ? -49.69764 -14.78923 8.48388   1.000 18.40015 ? 200 THR A O   1 
ATOM   1618 C CB  . THR A 1 200 ? -49.71342 -17.86708 8.29654   1.000 21.51517 ? 200 THR A CB  1 
ATOM   1619 O OG1 . THR A 1 200 ? -50.37436 -19.13049 8.22020   1.000 25.01496 ? 200 THR A OG1 1 
ATOM   1620 C CG2 . THR A 1 200 ? -48.28830 -18.11207 8.79563   1.000 16.48534 ? 200 THR A CG2 1 
ATOM   1621 N N   . LEU A 1 201 ? -49.02096 -15.45580 10.52564  1.000 15.92392 ? 201 LEU A N   1 
ATOM   1622 C CA  . LEU A 1 201 ? -48.04279 -14.39046 10.70910  1.000 12.14461 ? 201 LEU A CA  1 
ATOM   1623 C C   . LEU A 1 201 ? -46.68076 -15.05324 10.86895  1.000 16.21563 ? 201 LEU A C   1 
ATOM   1624 O O   . LEU A 1 201 ? -46.55449 -16.01512 11.62905  1.000 17.59666 ? 201 LEU A O   1 
ATOM   1625 C CB  . LEU A 1 201 ? -48.38826 -13.56396 11.94994  1.000 15.94722 ? 201 LEU A CB  1 
ATOM   1626 C CG  . LEU A 1 201 ? -49.43166 -12.44771 11.84809  1.000 15.53523 ? 201 LEU A CG  1 
ATOM   1627 C CD1 . LEU A 1 201 ? -49.55837 -11.79969 13.21649  1.000 19.32875 ? 201 LEU A CD1 1 
ATOM   1628 C CD2 . LEU A 1 201 ? -49.07573 -11.42141 10.78929  1.000 17.54317 ? 201 LEU A CD2 1 
ATOM   1629 N N   . ARG A 1 202 ? -45.66839 -14.55203 10.16079  1.000 15.14239 ? 202 ARG A N   1 
ATOM   1630 C CA  . ARG A 1 202 ? -44.33525 -15.15613 10.15394  1.000 15.09188 ? 202 ARG A CA  1 
ATOM   1631 C C   . ARG A 1 202 ? -43.31334 -14.07698 10.45583  1.000 17.38070 ? 202 ARG A C   1 
ATOM   1632 O O   . ARG A 1 202 ? -43.23856 -13.06761 9.74506   1.000 19.74044 ? 202 ARG A O   1 
ATOM   1633 C CB  . ARG A 1 202 ? -43.99135 -15.81658 8.81053   1.000 14.92579 ? 202 ARG A CB  1 
ATOM   1634 C CG  . ARG A 1 202 ? -42.68708 -16.63795 8.84056   1.000 18.99784 ? 202 ARG A CG  1 
ATOM   1635 C CD  . ARG A 1 202 ? -42.51839 -17.47129 7.57877   1.000 16.17472 ? 202 ARG A CD  1 
ATOM   1636 N NE  . ARG A 1 202 ? -43.25697 -18.72883 7.68675   1.000 20.18312 ? 202 ARG A NE  1 
ATOM   1637 C CZ  . ARG A 1 202 ? -44.32148 -19.02190 6.95401   1.000 19.28426 ? 202 ARG A CZ  1 
ATOM   1638 N NH1 . ARG A 1 202 ? -44.72221 -18.22775 5.97931   1.000 19.35812 ? 202 ARG A NH1 1 
ATOM   1639 N NH2 . ARG A 1 202 ? -45.00545 -20.13513 7.21080   1.000 17.83137 ? 202 ARG A NH2 1 
ATOM   1640 N N   . CYS A 1 203 ? -42.52607 -14.30503 11.49184  1.000 11.61983 ? 203 CYS A N   1 
ATOM   1641 C CA  . CYS A 1 203 ? -41.49417 -13.38885 11.94042  1.000 15.47199 ? 203 CYS A CA  1 
ATOM   1642 C C   . CYS A 1 203 ? -40.14346 -13.87665 11.42507  1.000 11.93815 ? 203 CYS A C   1 
ATOM   1643 O O   . CYS A 1 203 ? -39.78394 -15.02129 11.68870  1.000 13.04512 ? 203 CYS A O   1 
ATOM   1644 C CB  . CYS A 1 203 ? -41.51201 -13.36530 13.46585  1.000 17.94371 ? 203 CYS A CB  1 
ATOM   1645 S SG  . CYS A 1 203 ? -40.38417 -12.23661 14.18788  1.000 26.52026 ? 203 CYS A SG  1 
ATOM   1646 N N   . TRP A 1 204 ? -39.39823 -13.02537 10.70173  1.000 13.06988 ? 204 TRP A N   1 
ATOM   1647 C CA  . TRP A 1 204 ? -38.13782 -13.43274 10.06870  1.000 13.83094 ? 204 TRP A CA  1 
ATOM   1648 C C   . TRP A 1 204 ? -36.92655 -12.79143 10.73200  1.000 14.99832 ? 204 TRP A C   1 
ATOM   1649 O O   . TRP A 1 204 ? -36.96931 -11.62241 11.10374  1.000 18.01202 ? 204 TRP A O   1 
ATOM   1650 C CB  . TRP A 1 204 ? -38.11446 -13.04716 8.58821   1.000 12.47015 ? 204 TRP A CB  1 
ATOM   1651 C CG  . TRP A 1 204 ? -38.92189 -13.90836 7.69711   1.000 17.37590 ? 204 TRP A CG  1 
ATOM   1652 C CD1 . TRP A 1 204 ? -40.24399 -13.76765 7.37505   1.000 17.28235 ? 204 TRP A CD1 1 
ATOM   1653 C CD2 . TRP A 1 204 ? -38.44449 -15.03913 6.97413   1.000 16.45087 ? 204 TRP A CD2 1 
ATOM   1654 N NE1 . TRP A 1 204 ? -40.62149 -14.76447 6.49440   1.000 16.82621 ? 204 TRP A NE1 1 
ATOM   1655 C CE2 . TRP A 1 204 ? -39.52681 -15.55698 6.24286   1.000 18.58705 ? 204 TRP A CE2 1 
ATOM   1656 C CE3 . TRP A 1 204 ? -37.19882 -15.67781 6.89790   1.000 16.58250 ? 204 TRP A CE3 1 
ATOM   1657 C CZ2 . TRP A 1 204 ? -39.40032 -16.67790 5.42753   1.000 22.72857 ? 204 TRP A CZ2 1 
ATOM   1658 C CZ3 . TRP A 1 204 ? -37.06939 -16.77787 6.09569   1.000 20.50335 ? 204 TRP A CZ3 1 
ATOM   1659 C CH2 . TRP A 1 204 ? -38.16809 -17.27327 5.37153   1.000 22.69702 ? 204 TRP A CH2 1 
ATOM   1660 N N   . ALA A 1 205 ? -35.82458 -13.54643 10.84532  1.000 12.47754 ? 205 ALA A N   1 
ATOM   1661 C CA  . ALA A 1 205 ? -34.52679 -12.97511 11.17318  1.000 14.45652 ? 205 ALA A CA  1 
ATOM   1662 C C   . ALA A 1 205 ? -33.53459 -13.39468 10.10372  1.000 15.47576 ? 205 ALA A C   1 
ATOM   1663 O O   . ALA A 1 205 ? -33.38716 -14.59355 9.84322   1.000 12.65342 ? 205 ALA A O   1 
ATOM   1664 C CB  . ALA A 1 205 ? -34.02383 -13.44152 12.54029  1.000 16.00007 ? 205 ALA A CB  1 
ATOM   1665 N N   . LEU A 1 206 ? -32.83984 -12.41850 9.50054   1.000 15.14058 ? 206 LEU A N   1 
ATOM   1666 C CA  . LEU A 1 206 ? -31.91465 -12.70500 8.40789   1.000 15.34650 ? 206 LEU A CA  1 
ATOM   1667 C C   . LEU A 1 206 ? -30.56203 -12.03580 8.63084   1.000 16.75379 ? 206 LEU A C   1 
ATOM   1668 O O   . LEU A 1 206 ? -30.47071 -10.97376 9.25117   1.000 19.72580 ? 206 LEU A O   1 
ATOM   1669 C CB  . LEU A 1 206 ? -32.47914 -12.24616 7.03390   1.000 18.77675 ? 206 LEU A CB  1 
ATOM   1670 C CG  . LEU A 1 206 ? -33.81440 -12.80798 6.51789   1.000 17.88989 ? 206 LEU A CG  1 
ATOM   1671 C CD1 . LEU A 1 206 ? -34.27465 -12.09077 5.23206   1.000 20.90516 ? 206 LEU A CD1 1 
ATOM   1672 C CD2 . LEU A 1 206 ? -33.74213 -14.30802 6.28348   1.000 17.53914 ? 206 LEU A CD2 1 
ATOM   1673 N N   . GLY A 1 207 ? -29.51367 -12.66489 8.09291   1.000 20.50469 ? 207 GLY A N   1 
ATOM   1674 C CA  . GLY A 1 207 ? -28.17289 -12.09648 8.06578   1.000 18.23678 ? 207 GLY A CA  1 
ATOM   1675 C C   . GLY A 1 207 ? -27.52557 -11.93441 9.41593   1.000 18.89688 ? 207 GLY A C   1 
ATOM   1676 O O   . GLY A 1 207 ? -26.78775 -10.96866 9.62987   1.000 21.33422 ? 207 GLY A O   1 
ATOM   1677 N N   . PHE A 1 208 ? -27.79715 -12.83241 10.35224  1.000 15.35773 ? 208 PHE A N   1 
ATOM   1678 C CA  . PHE A 1 208 ? -27.22657 -12.67363 11.67600  1.000 19.58720 ? 208 PHE A CA  1 
ATOM   1679 C C   . PHE A 1 208 ? -26.06742 -13.64150 11.88002  1.000 20.21624 ? 208 PHE A C   1 
ATOM   1680 O O   . PHE A 1 208 ? -25.97037 -14.68515 11.22548  1.000 19.21164 ? 208 PHE A O   1 
ATOM   1681 C CB  . PHE A 1 208 ? -28.28832 -12.82732 12.77919  1.000 19.40535 ? 208 PHE A CB  1 
ATOM   1682 C CG  . PHE A 1 208 ? -29.01479 -14.14574 12.78947  1.000 17.85523 ? 208 PHE A CG  1 
ATOM   1683 C CD1 . PHE A 1 208 ? -28.55258 -15.21012 13.57044  1.000 17.45917 ? 208 PHE A CD1 1 
ATOM   1684 C CD2 . PHE A 1 208 ? -30.19361 -14.30792 12.07577  1.000 16.05807 ? 208 PHE A CD2 1 
ATOM   1685 C CE1 . PHE A 1 208 ? -29.23918 -16.41482 13.60804  1.000 16.08190 ? 208 PHE A CE1 1 
ATOM   1686 C CE2 . PHE A 1 208 ? -30.88353 -15.51826 12.09990  1.000 14.91538 ? 208 PHE A CE2 1 
ATOM   1687 C CZ  . PHE A 1 208 ? -30.40508 -16.57417 12.85439  1.000 16.31929 ? 208 PHE A CZ  1 
ATOM   1688 N N   . TYR A 1 209 ? -25.16615 -13.25382 12.77824  1.000 20.61350 ? 209 TYR A N   1 
ATOM   1689 C CA  . TYR A 1 209 ? -23.99592 -14.01715 13.16734  1.000 18.62796 ? 209 TYR A CA  1 
ATOM   1690 C C   . TYR A 1 209 ? -23.66795 -13.51841 14.56519  1.000 17.15054 ? 209 TYR A C   1 
ATOM   1691 O O   . TYR A 1 209 ? -23.68779 -12.29965 14.78588  1.000 18.96939 ? 209 TYR A O   1 
ATOM   1692 C CB  . TYR A 1 209 ? -22.78908 -13.81980 12.24429  1.000 19.75678 ? 209 TYR A CB  1 
ATOM   1693 C CG  . TYR A 1 209 ? -21.62602 -14.70641 12.64838  1.000 18.85956 ? 209 TYR A CG  1 
ATOM   1694 C CD1 . TYR A 1 209 ? -20.72730 -14.30155 13.63322  1.000 18.67311 ? 209 TYR A CD1 1 
ATOM   1695 C CD2 . TYR A 1 209 ? -21.43705 -15.94783 12.05507  1.000 22.11985 ? 209 TYR A CD2 1 
ATOM   1696 C CE1 . TYR A 1 209 ? -19.67813 -15.11407 14.02995  1.000 17.83405 ? 209 TYR A CE1 1 
ATOM   1697 C CE2 . TYR A 1 209 ? -20.37267 -16.76954 12.43171  1.000 19.55492 ? 209 TYR A CE2 1 
ATOM   1698 C CZ  . TYR A 1 209 ? -19.50920 -16.35323 13.42852  1.000 19.65405 ? 209 TYR A CZ  1 
ATOM   1699 O OH  . TYR A 1 209 ? -18.46879 -17.17730 13.80995  1.000 19.73214 ? 209 TYR A OH  1 
ATOM   1700 N N   . PRO A 1 210 ? -23.39169 -14.40315 15.52642  1.000 19.64091 ? 210 PRO A N   1 
ATOM   1701 C CA  . PRO A 1 210 ? -23.38101 -15.87244 15.45214  1.000 22.12127 ? 210 PRO A CA  1 
ATOM   1702 C C   . PRO A 1 210 ? -24.78237 -16.46570 15.33164  1.000 20.70002 ? 210 PRO A C   1 
ATOM   1703 O O   . PRO A 1 210 ? -25.79666 -15.74931 15.30370  1.000 19.07412 ? 210 PRO A O   1 
ATOM   1704 C CB  . PRO A 1 210 ? -22.69723 -16.27368 16.76528  1.000 23.19027 ? 210 PRO A CB  1 
ATOM   1705 C CG  . PRO A 1 210 ? -23.02460 -15.17110 17.71307  1.000 21.36100 ? 210 PRO A CG  1 
ATOM   1706 C CD  . PRO A 1 210 ? -23.06131 -13.92025 16.88063  1.000 23.70393 ? 210 PRO A CD  1 
ATOM   1707 N N   . ALA A 1 211 ? -24.87239 -17.79691 15.26240  1.000 17.50288 ? 211 ALA A N   1 
ATOM   1708 C CA  . ALA A 1 211 ? -26.14949 -18.43053 14.95767  1.000 18.77672 ? 211 ALA A CA  1 
ATOM   1709 C C   . ALA A 1 211 ? -27.13464 -18.38315 16.12788  1.000 18.72244 ? 211 ALA A C   1 
ATOM   1710 O O   . ALA A 1 211 ? -28.35261 -18.42369 15.90416  1.000 18.09360 ? 211 ALA A O   1 
ATOM   1711 C CB  . ALA A 1 211 ? -25.89796 -19.87057 14.51636  1.000 17.20746 ? 211 ALA A CB  1 
ATOM   1712 N N   . GLU A 1 212 ? -26.63636 -18.33220 17.36202  1.000 18.04983 ? 212 GLU A N   1 
ATOM   1713 C CA  . GLU A 1 212 ? -27.48121 -18.25362 18.54971  1.000 22.71976 ? 212 GLU A CA  1 
ATOM   1714 C C   . GLU A 1 212 ? -28.50216 -17.12297 18.42854  1.000 19.48563 ? 212 GLU A C   1 
ATOM   1715 O O   . GLU A 1 212 ? -28.11508 -15.97867 18.17738  1.000 17.90393 ? 212 GLU A O   1 
ATOM   1716 C CB  . GLU A 1 212 ? -26.58885 -18.02657 19.77219  1.000 22.04516 ? 212 GLU A CB  1 
ATOM   1717 C CG  . GLU A 1 212 ? -27.23248 -18.24634 21.12387  1.000 25.11003 ? 212 GLU A CG  1 
ATOM   1718 C CD  . GLU A 1 212 ? -28.18103 -19.41631 21.11854  1.000 31.28224 ? 212 GLU A CD  1 
ATOM   1719 O OE1 . GLU A 1 212 ? -27.71137 -20.55499 20.88962  1.000 41.71878 ? 212 GLU A OE1 1 
ATOM   1720 O OE2 . GLU A 1 212 ? -29.38653 -19.20077 21.37021  1.000 37.49654 ? 212 GLU A OE2 1 
ATOM   1721 N N   . ILE A 1 213 ? -29.77017 -17.43033 18.62914  1.000 22.29399 ? 213 ILE A N   1 
ATOM   1722 C CA  . ILE A 1 213 ? -30.83803 -16.42809 18.54074  1.000 18.16108 ? 213 ILE A CA  1 
ATOM   1723 C C   . ILE A 1 213 ? -32.09907 -16.98822 19.18724  1.000 19.48888 ? 213 ILE A C   1 
ATOM   1724 O O   . ILE A 1 213 ? -32.29053 -18.20757 19.24159  1.000 18.21551 ? 213 ILE A O   1 
ATOM   1725 C CB  . ILE A 1 213 ? -31.07659 -16.06096 17.05012  1.000 15.26458 ? 213 ILE A CB  1 
ATOM   1726 C CG1 . ILE A 1 213 ? -31.96101 -14.81952 16.92612  1.000 18.14195 ? 213 ILE A CG1 1 
ATOM   1727 C CG2 . ILE A 1 213 ? -31.73225 -17.22863 16.31154  1.000 16.78324 ? 213 ILE A CG2 1 
ATOM   1728 C CD1 . ILE A 1 213 ? -31.91750 -14.15298 15.53362  1.000 17.68434 ? 213 ILE A CD1 1 
ATOM   1729 N N   . THR A 1 214 ? -32.99515 -16.09917 19.63657  1.000 19.15763 ? 214 THR A N   1 
ATOM   1730 C CA  . THR A 1 214 ? -34.29232 -16.52205 20.17096  1.000 19.57821 ? 214 THR A CA  1 
ATOM   1731 C C   . THR A 1 214 ? -35.40086 -15.72079 19.50596  1.000 17.49828 ? 214 THR A C   1 
ATOM   1732 O O   . THR A 1 214 ? -35.37626 -14.48621 19.53525  1.000 20.77652 ? 214 THR A O   1 
ATOM   1733 C CB  . THR A 1 214 ? -34.37470 -16.35236 21.69522  1.000 22.20020 ? 214 THR A CB  1 
ATOM   1734 O OG1 . THR A 1 214 ? -33.30007 -17.06120 22.31351  1.000 22.63893 ? 214 THR A OG1 1 
ATOM   1735 C CG2 . THR A 1 214 ? -35.68263 -16.94531 22.20798  1.000 19.75552 ? 214 THR A CG2 1 
ATOM   1736 N N   . LEU A 1 215 ? -36.34747 -16.42756 18.88640  1.000 18.69369 ? 215 LEU A N   1 
ATOM   1737 C CA  . LEU A 1 215 ? -37.59946 -15.86605 18.39407  1.000 18.89661 ? 215 LEU A CA  1 
ATOM   1738 C C   . LEU A 1 215 ? -38.72616 -16.45593 19.22582  1.000 21.41213 ? 215 LEU A C   1 
ATOM   1739 O O   . LEU A 1 215 ? -38.79468 -17.67864 19.39372  1.000 21.05701 ? 215 LEU A O   1 
ATOM   1740 C CB  . LEU A 1 215 ? -37.83940 -16.19965 16.91696  1.000 17.09698 ? 215 LEU A CB  1 
ATOM   1741 C CG  . LEU A 1 215 ? -36.69391 -15.94592 15.93871  1.000 22.22312 ? 215 LEU A CG  1 
ATOM   1742 C CD1 . LEU A 1 215 ? -37.15860 -16.12704 14.48729  1.000 16.77119 ? 215 LEU A CD1 1 
ATOM   1743 C CD2 . LEU A 1 215 ? -36.11858 -14.57760 16.14365  1.000 22.71357 ? 215 LEU A CD2 1 
ATOM   1744 N N   . THR A 1 216 ? -39.59441 -15.59516 19.75315  1.000 19.35235 ? 216 THR A N   1 
ATOM   1745 C CA  . THR A 1 216 ? -40.73758 -16.03089 20.53830  1.000 20.34569 ? 216 THR A CA  1 
ATOM   1746 C C   . THR A 1 216 ? -41.93366 -15.15340 20.20085  1.000 20.34555 ? 216 THR A C   1 
ATOM   1747 O O   . THR A 1 216 ? -41.78547 -13.94908 20.01580  1.000 19.58666 ? 216 THR A O   1 
ATOM   1748 C CB  . THR A 1 216 ? -40.48289 -15.94296 22.06248  1.000 18.10688 ? 216 THR A CB  1 
ATOM   1749 O OG1 . THR A 1 216 ? -40.10782 -14.60955 22.40380  1.000 27.83601 ? 216 THR A OG1 1 
ATOM   1750 C CG2 . THR A 1 216 ? -39.39650 -16.87434 22.48920  1.000 19.38175 ? 216 THR A CG2 1 
ATOM   1751 N N   . TRP A 1 217 ? -43.11021 -15.76416 20.15993  1.000 19.49079 ? 217 TRP A N   1 
ATOM   1752 C CA  . TRP A 1 217 ? -44.37807 -15.07869 19.94193  1.000 17.53503 ? 217 TRP A CA  1 
ATOM   1753 C C   . TRP A 1 217 ? -45.10552 -14.87797 21.26932  1.000 24.89939 ? 217 TRP A C   1 
ATOM   1754 O O   . TRP A 1 217 ? -45.12758 -15.77364 22.12000  1.000 26.70705 ? 217 TRP A O   1 
ATOM   1755 C CB  . TRP A 1 217 ? -45.27019 -15.88471 18.99866  1.000 17.69937 ? 217 TRP A CB  1 
ATOM   1756 C CG  . TRP A 1 217 ? -44.99417 -15.68138 17.53267  1.000 20.28040 ? 217 TRP A CG  1 
ATOM   1757 C CD1 . TRP A 1 217 ? -44.37463 -16.55631 16.69049  1.000 20.55910 ? 217 TRP A CD1 1 
ATOM   1758 C CD2 . TRP A 1 217 ? -45.33811 -14.53655 16.73986  1.000 20.65812 ? 217 TRP A CD2 1 
ATOM   1759 N NE1 . TRP A 1 217 ? -44.31425 -16.03312 15.41685  1.000 18.79235 ? 217 TRP A NE1 1 
ATOM   1760 C CE2 . TRP A 1 217 ? -44.89235 -14.78956 15.42366  1.000 18.28187 ? 217 TRP A CE2 1 
ATOM   1761 C CE3 . TRP A 1 217 ? -45.98303 -13.32451 17.01150  1.000 21.01033 ? 217 TRP A CE3 1 
ATOM   1762 C CZ2 . TRP A 1 217 ? -45.06471 -13.88015 14.38997  1.000 18.51833 ? 217 TRP A CZ2 1 
ATOM   1763 C CZ3 . TRP A 1 217 ? -46.15581 -12.41147 15.97169  1.000 20.48478 ? 217 TRP A CZ3 1 
ATOM   1764 C CH2 . TRP A 1 217 ? -45.70034 -12.69531 14.67843  1.000 22.62098 ? 217 TRP A CH2 1 
ATOM   1765 N N   . GLN A 1 218 ? -45.71668 -13.70303 21.43066  1.000 20.79321 ? 218 GLN A N   1 
ATOM   1766 C CA  . GLN A 1 218 ? -46.55942 -13.38191 22.57467  1.000 18.89848 ? 218 GLN A CA  1 
ATOM   1767 C C   . GLN A 1 218 ? -47.94147 -13.01181 22.04855  1.000 22.78252 ? 218 GLN A C   1 
ATOM   1768 O O   . GLN A 1 218 ? -48.07526 -12.47386 20.93630  1.000 17.46163 ? 218 GLN A O   1 
ATOM   1769 C CB  . GLN A 1 218 ? -45.98357 -12.20074 23.35460  1.000 22.45534 ? 218 GLN A CB  1 
ATOM   1770 C CG  . GLN A 1 218 ? -44.61252 -12.45709 23.94252  1.000 22.20792 ? 218 GLN A CG  1 
ATOM   1771 C CD  . GLN A 1 218 ? -44.25360 -11.47786 25.02616  1.000 27.32062 ? 218 GLN A CD  1 
ATOM   1772 O OE1 . GLN A 1 218 ? -44.78920 -10.37064 25.08482  1.000 28.71476 ? 218 GLN A OE1 1 
ATOM   1773 N NE2 . GLN A 1 218 ? -43.32806 -11.86763 25.88024  1.000 30.18032 ? 218 GLN A NE2 1 
ATOM   1774 N N   . ARG A 1 219 ? -48.96714 -13.33353 22.82747  1.000 21.98399 ? 219 ARG A N   1 
ATOM   1775 C CA  . ARG A 1 219 ? -50.32967 -12.86310 22.58035  1.000 20.57417 ? 219 ARG A CA  1 
ATOM   1776 C C   . ARG A 1 219 ? -50.77281 -12.09587 23.81244  1.000 22.27690 ? 219 ARG A C   1 
ATOM   1777 O O   . ARG A 1 219 ? -50.73778 -12.64367 24.91549  1.000 23.99300 ? 219 ARG A O   1 
ATOM   1778 C CB  . ARG A 1 219 ? -51.29535 -14.01529 22.32895  1.000 25.31757 ? 219 ARG A CB  1 
ATOM   1779 C CG  . ARG A 1 219 ? -52.72928 -13.51982 22.29663  1.000 21.76107 ? 219 ARG A CG  1 
ATOM   1780 C CD  . ARG A 1 219 ? -53.69604 -14.59202 21.87886  1.000 27.61183 ? 219 ARG A CD  1 
ATOM   1781 N NE  . ARG A 1 219 ? -53.94186 -15.54338 22.96064  1.000 28.10426 ? 219 ARG A NE  1 
ATOM   1782 C CZ  . ARG A 1 219 ? -54.46334 -15.25114 24.14823  1.000 34.71489 ? 219 ARG A CZ  1 
ATOM   1783 N NH1 . ARG A 1 219 ? -54.82159 -14.01109 24.47564  1.000 29.66238 ? 219 ARG A NH1 1 
ATOM   1784 N NH2 . ARG A 1 219 ? -54.65038 -16.23191 25.02902  1.000 39.95630 ? 219 ARG A NH2 1 
ATOM   1785 N N   . ASP A 1 220 ? -51.18095 -10.83748 23.62913  1.000 25.31749 ? 220 ASP A N   1 
ATOM   1786 C CA  . ASP A 1 220 ? -51.50504 -9.95936  24.75352  1.000 27.40295 ? 220 ASP A CA  1 
ATOM   1787 C C   . ASP A 1 220 ? -50.42805 -10.04017 25.83122  1.000 30.11445 ? 220 ASP A C   1 
ATOM   1788 O O   . ASP A 1 220 ? -50.71731 -10.13141 27.02482  1.000 27.28257 ? 220 ASP A O   1 
ATOM   1789 C CB  . ASP A 1 220 ? -52.89453 -10.27410 25.32721  1.000 28.54933 ? 220 ASP A CB  1 
ATOM   1790 C CG  . ASP A 1 220 ? -54.02084 -9.96937  24.34227  1.000 30.16213 ? 220 ASP A CG  1 
ATOM   1791 O OD1 . ASP A 1 220 ? -55.05006 -10.67839 24.33910  1.000 27.10105 ? 220 ASP A OD1 1 
ATOM   1792 O OD2 . ASP A 1 220 ? -53.88802 -8.96906  23.60028  1.000 32.87431 ? 220 ASP A OD2 1 
ATOM   1793 N N   . GLY A 1 221 ? -49.16783 -10.04951 25.39154  1.000 30.54316 ? 221 GLY A N   1 
ATOM   1794 C CA  . GLY A 1 221 ? -48.03270 -10.02690 26.29438  1.000 29.09961 ? 221 GLY A CA  1 
ATOM   1795 C C   . GLY A 1 221 ? -47.74069 -11.30795 27.04606  1.000 31.15664 ? 221 GLY A C   1 
ATOM   1796 O O   . GLY A 1 221 ? -46.97377 -11.28177 28.00651  1.000 32.78887 ? 221 GLY A O   1 
ATOM   1797 N N   . GLU A 1 222 ? -48.30400 -12.43738 26.64158  1.000 26.90259 ? 222 GLU A N   1 
ATOM   1798 C CA  . GLU A 1 222 ? -47.98616 -13.70241 27.27998  1.000 28.94994 ? 222 GLU A CA  1 
ATOM   1799 C C   . GLU A 1 222 ? -47.46623 -14.69202 26.24869  1.000 30.12270 ? 222 GLU A C   1 
ATOM   1800 O O   . GLU A 1 222 ? -47.99185 -14.78140 25.13457  1.000 26.96461 ? 222 GLU A O   1 
ATOM   1801 C CB  . GLU A 1 222 ? -49.20492 -14.27645 28.00805  1.000 32.97704 ? 222 GLU A CB  1 
ATOM   1802 C CG  . GLU A 1 222 ? -49.86985 -13.27448 28.95214  1.000 38.38889 ? 222 GLU A CG  1 
ATOM   1803 C CD  . GLU A 1 222 ? -49.01423 -12.89883 30.18313  1.000 43.28934 ? 222 GLU A CD  1 
ATOM   1804 O OE1 . GLU A 1 222 ? -47.95837 -13.53110 30.43202  1.000 47.81335 ? 222 GLU A OE1 1 
ATOM   1805 O OE2 . GLU A 1 222 ? -49.40759 -11.95859 30.91308  1.000 45.39922 ? 222 GLU A OE2 1 
ATOM   1806 N N   . ASP A 1 223 ? -46.43541 -15.44051 26.63681  1.000 32.35007 ? 223 ASP A N   1 
ATOM   1807 C CA  . ASP A 1 223 ? -45.76566 -16.34144 25.71132  1.000 33.14779 ? 223 ASP A CA  1 
ATOM   1808 C C   . ASP A 1 223 ? -46.77859 -17.28803 25.09077  1.000 35.24557 ? 223 ASP A C   1 
ATOM   1809 O O   . ASP A 1 223 ? -47.72964 -17.71457 25.74816  1.000 38.52677 ? 223 ASP A O   1 
ATOM   1810 C CB  . ASP A 1 223 ? -44.68917 -17.13388 26.44482  1.000 37.27461 ? 223 ASP A CB  1 
ATOM   1811 C CG  . ASP A 1 223 ? -43.38075 -16.41049 26.47275  1.000 38.87741 ? 223 ASP A CG  1 
ATOM   1812 O OD1 . ASP A 1 223 ? -43.34317 -15.27752 25.95134  1.000 35.88397 ? 223 ASP A OD1 1 
ATOM   1813 O OD2 . ASP A 1 223 ? -42.39732 -16.96201 27.01102  1.000 50.07702 ? 223 ASP A OD2 1 
ATOM   1814 N N   . GLN A 1 224 ? -46.58344 -17.61124 23.81530  1.000 30.63396 ? 224 GLN A N   1 
ATOM   1815 C CA  . GLN A 1 224 ? -47.55118 -18.40925 23.08186  1.000 34.02095 ? 224 GLN A CA  1 
ATOM   1816 C C   . GLN A 1 224 ? -46.82859 -19.53234 22.36339  1.000 38.28836 ? 224 GLN A C   1 
ATOM   1817 O O   . GLN A 1 224 ? -45.97989 -19.28236 21.50302  1.000 40.87627 ? 224 GLN A O   1 
ATOM   1818 C CB  . GLN A 1 224 ? -48.33877 -17.55481 22.08343  1.000 33.02143 ? 224 GLN A CB  1 
ATOM   1819 C CG  . GLN A 1 224 ? -49.05221 -18.39693 21.03888  1.000 37.80326 ? 224 GLN A CG  1 
ATOM   1820 C CD  . GLN A 1 224 ? -50.54496 -18.23605 21.09362  1.000 37.00052 ? 224 GLN A CD  1 
ATOM   1821 O OE1 . GLN A 1 224 ? -51.06987 -17.63552 22.02167  1.000 40.99893 ? 224 GLN A OE1 1 
ATOM   1822 N NE2 . GLN A 1 224 ? -51.24699 -18.80681 20.11829  1.000 39.64795 ? 224 GLN A NE2 1 
ATOM   1823 N N   . THR A 1 225 ? -47.17306 -20.76438 22.71119  1.000 43.18732 ? 225 THR A N   1 
ATOM   1824 C CA  . THR A 1 225 ? -46.64046 -21.94812 22.05678  1.000 45.00073 ? 225 THR A CA  1 
ATOM   1825 C C   . THR A 1 225 ? -47.68127 -22.67492 21.21175  1.000 38.58907 ? 225 THR A C   1 
ATOM   1826 O O   . THR A 1 225 ? -47.33310 -23.26704 20.18833  1.000 40.32376 ? 225 THR A O   1 
ATOM   1827 C CB  . THR A 1 225 ? -46.05201 -22.89257 23.11717  1.000 42.76543 ? 225 THR A CB  1 
ATOM   1828 O OG1 . THR A 1 225 ? -44.77031 -22.38857 23.53015  1.000 43.30538 ? 225 THR A OG1 1 
ATOM   1829 C CG2 . THR A 1 225 ? -45.89102 -24.30999 22.58655  1.000 49.07896 ? 225 THR A CG2 1 
ATOM   1830 N N   . GLN A 1 226 ? -48.95739 -22.59623 21.58447  1.000 44.99056 ? 226 GLN A N   1 
ATOM   1831 C CA  . GLN A 1 226 ? -50.00943 -23.20503 20.78081  1.000 41.73495 ? 226 GLN A CA  1 
ATOM   1832 C C   . GLN A 1 226 ? -50.05693 -22.57388 19.38907  1.000 40.68616 ? 226 GLN A C   1 
ATOM   1833 O O   . GLN A 1 226 ? -50.01640 -21.34847 19.24672  1.000 39.91851 ? 226 GLN A O   1 
ATOM   1834 C CB  . GLN A 1 226 ? -51.37082 -23.06873 21.47995  1.000 40.04215 ? 226 GLN A CB  1 
ATOM   1835 C CG  . GLN A 1 226 ? -51.68738 -21.72340 22.20290  1.000 49.43488 ? 226 GLN A CG  1 
ATOM   1836 C CD  . GLN A 1 226 ? -50.91195 -21.47260 23.51794  1.000 53.48325 ? 226 GLN A CD  1 
ATOM   1837 O OE1 . GLN A 1 226 ? -49.72498 -21.80333 23.63907  1.000 42.55853 ? 226 GLN A OE1 1 
ATOM   1838 N NE2 . GLN A 1 226 ? -51.60073 -20.88852 24.50920  1.000 45.03070 ? 226 GLN A NE2 1 
ATOM   1839 N N   . ASP A 1 227 ? -50.13433 -23.42381 18.36109  1.000 34.15587 ? 227 ASP A N   1 
ATOM   1840 C CA  . ASP A 1 227 ? -50.25291 -22.99980 16.96143  1.000 38.53363 ? 227 ASP A CA  1 
ATOM   1841 C C   . ASP A 1 227 ? -49.06134 -22.15958 16.48923  1.000 36.63161 ? 227 ASP A C   1 
ATOM   1842 O O   . ASP A 1 227 ? -49.21309 -21.34520 15.57108  1.000 32.09983 ? 227 ASP A O   1 
ATOM   1843 C CB  . ASP A 1 227 ? -51.55085 -22.22032 16.69590  1.000 36.55350 ? 227 ASP A CB  1 
ATOM   1844 C CG  . ASP A 1 227 ? -52.74732 -22.78831 17.42288  1.000 41.34150 ? 227 ASP A CG  1 
ATOM   1845 O OD1 . ASP A 1 227 ? -53.33579 -23.77497 16.93462  1.000 47.53390 ? 227 ASP A OD1 1 
ATOM   1846 O OD2 . ASP A 1 227 ? -53.13160 -22.21196 18.46061  1.000 46.69101 ? 227 ASP A OD2 1 
ATOM   1847 N N   . THR A 1 228 ? -47.88276 -22.33746 17.10216  1.000 29.96413 ? 228 THR A N   1 
ATOM   1848 C CA  . THR A 1 228 ? -46.64121 -21.71699 16.64636  1.000 36.18097 ? 228 THR A CA  1 
ATOM   1849 C C   . THR A 1 228 ? -45.73864 -22.75358 15.99013  1.000 35.39559 ? 228 THR A C   1 
ATOM   1850 O O   . THR A 1 228 ? -45.81459 -23.94751 16.29884  1.000 36.01364 ? 228 THR A O   1 
ATOM   1851 C CB  . THR A 1 228 ? -45.87293 -21.05021 17.78976  1.000 31.33541 ? 228 THR A CB  1 
ATOM   1852 O OG1 . THR A 1 228 ? -45.34705 -22.05898 18.65405  1.000 36.26450 ? 228 THR A OG1 1 
ATOM   1853 C CG2 . THR A 1 228 ? -46.78270 -20.14017 18.58693  1.000 34.18317 ? 228 THR A CG2 1 
ATOM   1854 N N   . GLU A 1 229 ? -44.88480 -22.28468 15.07559  1.000 32.52904 ? 229 GLU A N   1 
ATOM   1855 C CA  . GLU A 1 229 ? -43.95354 -23.14908 14.36175  1.000 28.47396 ? 229 GLU A CA  1 
ATOM   1856 C C   . GLU A 1 229 ? -42.60848 -22.43836 14.25729  1.000 23.39635 ? 229 GLU A C   1 
ATOM   1857 O O   . GLU A 1 229 ? -42.52951 -21.30487 13.76652  1.000 21.63913 ? 229 GLU A O   1 
ATOM   1858 C CB  . GLU A 1 229 ? -44.47319 -23.47747 12.96124  1.000 28.47017 ? 229 GLU A CB  1 
ATOM   1859 C CG  . GLU A 1 229 ? -43.77344 -24.63160 12.29081  1.000 27.19193 ? 229 GLU A CG  1 
ATOM   1860 C CD  . GLU A 1 229 ? -43.95575 -24.62188 10.78407  1.000 35.44874 ? 229 GLU A CD  1 
ATOM   1861 O OE1 . GLU A 1 229 ? -45.09494 -24.79654 10.30839  1.000 38.53797 ? 229 GLU A OE1 1 
ATOM   1862 O OE2 . GLU A 1 229 ? -42.93983 -24.53609 10.06523  1.000 41.78119 ? 229 GLU A OE2 1 
ATOM   1863 N N   . LEU A 1 230 ? -41.55493 -23.11307 14.70112  1.000 21.83975 ? 230 LEU A N   1 
ATOM   1864 C CA  . LEU A 1 230 ? -40.20058 -22.57114 14.76710  1.000 18.74874 ? 230 LEU A CA  1 
ATOM   1865 C C   . LEU A 1 230 ? -39.26846 -23.47796 13.97712  1.000 25.76527 ? 230 LEU A C   1 
ATOM   1866 O O   . LEU A 1 230 ? -39.10097 -24.64489 14.34222  1.000 27.56333 ? 230 LEU A O   1 
ATOM   1867 C CB  . LEU A 1 230 ? -39.74475 -22.50621 16.22362  1.000 20.43256 ? 230 LEU A CB  1 
ATOM   1868 C CG  . LEU A 1 230 ? -38.56613 -21.66882 16.70468  1.000 23.92067 ? 230 LEU A CG  1 
ATOM   1869 C CD1 . LEU A 1 230 ? -38.70676 -20.19814 16.37130  1.000 20.39075 ? 230 LEU A CD1 1 
ATOM   1870 C CD2 . LEU A 1 230 ? -38.37403 -21.87785 18.22135  1.000 25.33750 ? 230 LEU A CD2 1 
ATOM   1871 N N   . VAL A 1 231 ? -38.63576 -22.95389 12.90903  1.000 22.05609 ? 231 VAL A N   1 
ATOM   1872 C CA  . VAL A 1 231 ? -37.78482 -23.82508 12.10501  1.000 14.56165 ? 231 VAL A CA  1 
ATOM   1873 C C   . VAL A 1 231 ? -36.36646 -23.75597 12.65325  1.000 18.22270 ? 231 VAL A C   1 
ATOM   1874 O O   . VAL A 1 231 ? -36.00138 -22.84838 13.40777  1.000 15.82753 ? 231 VAL A O   1 
ATOM   1875 C CB  . VAL A 1 231 ? -37.81772 -23.51353 10.59328  1.000 16.78418 ? 231 VAL A CB  1 
ATOM   1876 C CG1 . VAL A 1 231 ? -39.23591 -23.74002 10.04790  1.000 21.17256 ? 231 VAL A CG1 1 
ATOM   1877 C CG2 . VAL A 1 231 ? -37.29179 -22.13015 10.27869  1.000 17.28203 ? 231 VAL A CG2 1 
ATOM   1878 N N   . GLU A 1 232 ? -35.57264 -24.77343 12.32666  1.000 16.49487 ? 232 GLU A N   1 
ATOM   1879 C CA  . GLU A 1 232 ? -34.18864 -24.77550 12.76829  1.000 20.23698 ? 232 GLU A CA  1 
ATOM   1880 C C   . GLU A 1 232 ? -33.41474 -23.63505 12.12461  1.000 16.51577 ? 232 GLU A C   1 
ATOM   1881 O O   . GLU A 1 232 ? -33.64191 -23.28857 10.96667  1.000 18.45391 ? 232 GLU A O   1 
ATOM   1882 C CB  . GLU A 1 232 ? -33.51208 -26.08541 12.42158  1.000 20.58796 ? 232 GLU A CB  1 
ATOM   1883 C CG  . GLU A 1 232 ? -33.93312 -27.23734 13.28667  1.000 30.76210 ? 232 GLU A CG  1 
ATOM   1884 C CD  . GLU A 1 232 ? -33.06954 -28.45708 13.01365  1.000 41.78574 ? 232 GLU A CD  1 
ATOM   1885 O OE1 . GLU A 1 232 ? -32.13731 -28.36014 12.16813  1.000 41.73594 ? 232 GLU A OE1 1 
ATOM   1886 O OE2 . GLU A 1 232 ? -33.27919 -29.48292 13.69216  1.000 45.15937 ? 232 GLU A OE2 1 
ATOM   1887 N N   . THR A 1 233 ? -32.49176 -23.06291 12.88455  1.000 16.53873 ? 233 THR A N   1 
ATOM   1888 C CA  . THR A 1 233 ? -31.58047 -22.06176 12.34861  1.000 16.19653 ? 233 THR A CA  1 
ATOM   1889 C C   . THR A 1 233 ? -30.76953 -22.66427 11.21244  1.000 14.07434 ? 233 THR A C   1 
ATOM   1890 O O   . THR A 1 233 ? -30.26244 -23.78126 11.32252  1.000 20.26661 ? 233 THR A O   1 
ATOM   1891 C CB  . THR A 1 233 ? -30.66568 -21.55304 13.46035  1.000 17.56412 ? 233 THR A CB  1 
ATOM   1892 O OG1 . THR A 1 233 ? -31.47677 -20.95072 14.47081  1.000 17.50716 ? 233 THR A OG1 1 
ATOM   1893 C CG2 . THR A 1 233 ? -29.68760 -20.51981 12.93475  1.000 19.52281 ? 233 THR A CG2 1 
ATOM   1894 N N   . ARG A 1 234 ? -30.69522 -21.94414 10.09961  1.000 16.48138 ? 234 ARG A N   1 
ATOM   1895 C CA  . ARG A 1 234 ? -30.13681 -22.46499 8.86889   1.000 15.11067 ? 234 ARG A CA  1 
ATOM   1896 C C   . ARG A 1 234 ? -29.12725 -21.48223 8.29988   1.000 14.88046 ? 234 ARG A C   1 
ATOM   1897 O O   . ARG A 1 234 ? -29.24835 -20.26995 8.50539   1.000 16.03496 ? 234 ARG A O   1 
ATOM   1898 C CB  . ARG A 1 234 ? -31.23196 -22.71609 7.82281   1.000 12.39698 ? 234 ARG A CB  1 
ATOM   1899 C CG  . ARG A 1 234 ? -31.95092 -21.45031 7.43000   1.000 14.65493 ? 234 ARG A CG  1 
ATOM   1900 C CD  . ARG A 1 234 ? -33.28781 -21.76887 6.82592   1.000 12.75768 ? 234 ARG A CD  1 
ATOM   1901 N NE  . ARG A 1 234 ? -33.78452 -20.62902 6.07781   1.000 15.87164 ? 234 ARG A NE  1 
ATOM   1902 C CZ  . ARG A 1 234 ? -35.01105 -20.54259 5.58847   1.000 15.14512 ? 234 ARG A CZ  1 
ATOM   1903 N NH1 . ARG A 1 234 ? -35.87992 -21.53269 5.72936   1.000 14.11721 ? 234 ARG A NH1 1 
ATOM   1904 N NH2 . ARG A 1 234 ? -35.36150 -19.45053 4.91428   1.000 16.17114 ? 234 ARG A NH2 1 
ATOM   1905 N N   . PRO A 1 235 ? -28.13879 -21.97985 7.55257   1.000 13.60897 ? 235 PRO A N   1 
ATOM   1906 C CA  . PRO A 1 235 ? -27.12074 -21.09544 6.97514   1.000 14.97266 ? 235 PRO A CA  1 
ATOM   1907 C C   . PRO A 1 235 ? -27.58409 -20.44044 5.68484   1.000 18.51216 ? 235 PRO A C   1 
ATOM   1908 O O   . PRO A 1 235 ? -28.19134 -21.07329 4.81252   1.000 18.13830 ? 235 PRO A O   1 
ATOM   1909 C CB  . PRO A 1 235 ? -25.94315 -22.04765 6.70511   1.000 14.53344 ? 235 PRO A CB  1 
ATOM   1910 C CG  . PRO A 1 235 ? -26.62191 -23.36050 6.40593   1.000 16.56281 ? 235 PRO A CG  1 
ATOM   1911 C CD  . PRO A 1 235 ? -27.84103 -23.40613 7.31095   1.000 12.97466 ? 235 PRO A CD  1 
ATOM   1912 N N   . ALA A 1 236 ? -27.28461 -19.14752 5.57276   1.000 18.56953 ? 236 ALA A N   1 
ATOM   1913 C CA  . ALA A 1 236 ? -27.53135 -18.45247 4.32258   1.000 17.62387 ? 236 ALA A CA  1 
ATOM   1914 C C   . ALA A 1 236 ? -26.57105 -18.91335 3.23542   1.000 19.59841 ? 236 ALA A C   1 
ATOM   1915 O O   . ALA A 1 236 ? -26.92572 -18.86864 2.05640   1.000 17.90018 ? 236 ALA A O   1 
ATOM   1916 C CB  . ALA A 1 236 ? -27.43006 -16.94053 4.53484   1.000 18.26036 ? 236 ALA A CB  1 
ATOM   1917 N N   . GLY A 1 237 ? -25.36498 -19.38015 3.60738   1.000 15.51877 ? 237 GLY A N   1 
ATOM   1918 C CA  . GLY A 1 237 ? -24.31325 -19.68756 2.64969   1.000 20.87401 ? 237 GLY A CA  1 
ATOM   1919 C C   . GLY A 1 237 ? -23.20599 -18.65284 2.55193   1.000 19.43963 ? 237 GLY A C   1 
ATOM   1920 O O   . GLY A 1 237 ? -22.14917 -18.94061 1.96532   1.000 21.64209 ? 237 GLY A O   1 
ATOM   1921 N N   . ASP A 1 238 ? -23.41902 -17.45221 3.08738   1.000 22.22305 ? 238 ASP A N   1 
ATOM   1922 C CA  . ASP A 1 238 ? -22.43650 -16.37374 3.04036   1.000 22.57731 ? 238 ASP A CA  1 
ATOM   1923 C C   . ASP A 1 238 ? -21.76564 -16.15374 4.38683   1.000 22.19022 ? 238 ASP A C   1 
ATOM   1924 O O   . ASP A 1 238 ? -21.17204 -15.09266 4.61335   1.000 21.68097 ? 238 ASP A O   1 
ATOM   1925 C CB  . ASP A 1 238 ? -23.08152 -15.06019 2.59275   1.000 21.50721 ? 238 ASP A CB  1 
ATOM   1926 C CG  . ASP A 1 238 ? -24.35902 -14.75056 3.36255   1.000 22.21851 ? 238 ASP A CG  1 
ATOM   1927 O OD1 . ASP A 1 238 ? -24.52134 -15.27292 4.48477   1.000 25.18705 ? 238 ASP A OD1 1 
ATOM   1928 O OD2 . ASP A 1 238 ? -25.17519 -13.93854 2.88101   1.000 26.61557 ? 238 ASP A OD2 1 
ATOM   1929 N N   . GLY A 1 239 ? -21.88343 -17.10800 5.29789   1.000 21.01666 ? 239 GLY A N   1 
ATOM   1930 C CA  . GLY A 1 239 ? -21.35865 -16.95071 6.63371   1.000 18.62497 ? 239 GLY A CA  1 
ATOM   1931 C C   . GLY A 1 239 ? -22.36792 -16.50664 7.67906   1.000 22.21848 ? 239 GLY A C   1 
ATOM   1932 O O   . GLY A 1 239 ? -22.03022 -16.52049 8.86377   1.000 23.00635 ? 239 GLY A O   1 
ATOM   1933 N N   . THR A 1 240 ? -23.58102 -16.10133 7.28683   1.000 21.40867 ? 240 THR A N   1 
ATOM   1934 C CA  . THR A 1 240 ? -24.61737 -15.68699 8.23392   1.000 16.65374 ? 240 THR A CA  1 
ATOM   1935 C C   . THR A 1 240 ? -25.75005 -16.71972 8.25628   1.000 20.10571 ? 240 THR A C   1 
ATOM   1936 O O   . THR A 1 240 ? -25.77465 -17.67436 7.46450   1.000 18.14801 ? 240 THR A O   1 
ATOM   1937 C CB  . THR A 1 240 ? -25.18612 -14.30211 7.88453   1.000 21.68855 ? 240 THR A CB  1 
ATOM   1938 O OG1 . THR A 1 240 ? -25.80648 -14.36439 6.59780   1.000 18.64176 ? 240 THR A OG1 1 
ATOM   1939 C CG2 . THR A 1 240 ? -24.08799 -13.21533 7.87095   1.000 22.72970 ? 240 THR A CG2 1 
ATOM   1940 N N   . PHE A 1 241 ? -26.73942 -16.47576 9.12810   1.000 14.42925 ? 241 PHE A N   1 
ATOM   1941 C CA  . PHE A 1 241 ? -27.79138 -17.44137 9.40812   1.000 17.46529 ? 241 PHE A CA  1 
ATOM   1942 C C   . PHE A 1 241 ? -29.17189 -16.80358 9.29694   1.000 14.55154 ? 241 PHE A C   1 
ATOM   1943 O O   . PHE A 1 241 ? -29.31878 -15.58216 9.21335   1.000 13.70661 ? 241 PHE A O   1 
ATOM   1944 C CB  . PHE A 1 241 ? -27.57285 -18.07003 10.79549  1.000 16.23829 ? 241 PHE A CB  1 
ATOM   1945 C CG  . PHE A 1 241 ? -26.32204 -18.87221 10.84409  1.000 12.91642 ? 241 PHE A CG  1 
ATOM   1946 C CD1 . PHE A 1 241 ? -25.10020 -18.25417 11.09517  1.000 16.10016 ? 241 PHE A CD1 1 
ATOM   1947 C CD2 . PHE A 1 241 ? -26.33693 -20.21113 10.50014  1.000 16.06475 ? 241 PHE A CD2 1 
ATOM   1948 C CE1 . PHE A 1 241 ? -23.92212 -18.98097 11.05784  1.000 19.23799 ? 241 PHE A CE1 1 
ATOM   1949 C CE2 . PHE A 1 241 ? -25.14035 -20.94970 10.47540  1.000 15.88753 ? 241 PHE A CE2 1 
ATOM   1950 C CZ  . PHE A 1 241 ? -23.95084 -20.32425 10.75350  1.000 17.85318 ? 241 PHE A CZ  1 
ATOM   1951 N N   . GLN A 1 242 ? -30.18416 -17.67348 9.30311   1.000 14.17231 ? 242 GLN A N   1 
ATOM   1952 C CA  . GLN A 1 242 ? -31.57458 -17.30223 9.10529   1.000 15.80425 ? 242 GLN A CA  1 
ATOM   1953 C C   . GLN A 1 242 ? -32.43587 -18.16892 10.01149  1.000 12.79209 ? 242 GLN A C   1 
ATOM   1954 O O   . GLN A 1 242 ? -32.09997 -19.32055 10.29558  1.000 15.72385 ? 242 GLN A O   1 
ATOM   1955 C CB  . GLN A 1 242 ? -32.05311 -17.49888 7.64916   1.000 15.70471 ? 242 GLN A CB  1 
ATOM   1956 C CG  . GLN A 1 242 ? -31.10624 -17.08982 6.56262   1.000 14.46094 ? 242 GLN A CG  1 
ATOM   1957 C CD  . GLN A 1 242 ? -31.66992 -17.34635 5.16016   1.000 17.38967 ? 242 GLN A CD  1 
ATOM   1958 O OE1 . GLN A 1 242 ? -32.49804 -18.24008 4.95475   1.000 19.90540 ? 242 GLN A OE1 1 
ATOM   1959 N NE2 . GLN A 1 242 ? -31.25568 -16.52005 4.20150   1.000 18.25202 ? 242 GLN A NE2 1 
ATOM   1960 N N   . LYS A 1 243 ? -33.56876 -17.61191 10.43780  1.000 14.16057 ? 243 LYS A N   1 
ATOM   1961 C CA  . LYS A 1 243 ? -34.55130 -18.36334 11.20073  1.000 10.69942 ? 243 LYS A CA  1 
ATOM   1962 C C   . LYS A 1 243 ? -35.88620 -17.65122 11.06460  1.000 12.53506 ? 243 LYS A C   1 
ATOM   1963 O O   . LYS A 1 243 ? -35.92719 -16.43509 10.87849  1.000 10.00664 ? 243 LYS A O   1 
ATOM   1964 C CB  . LYS A 1 243 ? -34.15505 -18.45555 12.67780  1.000 12.40372 ? 243 LYS A CB  1 
ATOM   1965 C CG  . LYS A 1 243 ? -34.71991 -19.61450 13.45591  1.000 14.14737 ? 243 LYS A CG  1 
ATOM   1966 C CD  . LYS A 1 243 ? -34.33835 -19.45075 14.93961  1.000 15.38153 ? 243 LYS A CD  1 
ATOM   1967 C CE  . LYS A 1 243 ? -34.93205 -20.58376 15.78214  1.000 16.80039 ? 243 LYS A CE  1 
ATOM   1968 N NZ  . LYS A 1 243 ? -34.33872 -21.89127 15.41357  1.000 18.38282 ? 243 LYS A NZ  1 
ATOM   1969 N N   . TRP A 1 244 ? -36.97208 -18.40321 11.20742  1.000 11.21999 ? 244 TRP A N   1 
ATOM   1970 C CA  . TRP A 1 244 ? -38.27458 -17.75535 11.33640  1.000 12.59013 ? 244 TRP A CA  1 
ATOM   1971 C C   . TRP A 1 244 ? -39.14728 -18.49530 12.32989  1.000 15.30747 ? 244 TRP A C   1 
ATOM   1972 O O   . TRP A 1 244 ? -38.86479 -19.62493 12.72500  1.000 12.47697 ? 244 TRP A O   1 
ATOM   1973 C CB  . TRP A 1 244 ? -39.00675 -17.61377 9.99695   1.000 15.11719 ? 244 TRP A CB  1 
ATOM   1974 C CG  . TRP A 1 244 ? -39.29797 -18.85450 9.18492   1.000 16.01987 ? 244 TRP A CG  1 
ATOM   1975 C CD1 . TRP A 1 244 ? -38.58864 -19.29848 8.08944   1.000 15.41983 ? 244 TRP A CD1 1 
ATOM   1976 C CD2 . TRP A 1 244 ? -40.39923 -19.76281 9.33922   1.000 14.75744 ? 244 TRP A CD2 1 
ATOM   1977 N NE1 . TRP A 1 244 ? -39.17728 -20.42176 7.56973   1.000 18.33418 ? 244 TRP A NE1 1 
ATOM   1978 C CE2 . TRP A 1 244 ? -40.28355 -20.73511 8.31911   1.000 15.49108 ? 244 TRP A CE2 1 
ATOM   1979 C CE3 . TRP A 1 244 ? -41.45458 -19.86821 10.25748  1.000 16.67674 ? 244 TRP A CE3 1 
ATOM   1980 C CZ2 . TRP A 1 244 ? -41.18948 -21.77526 8.17590   1.000 22.00193 ? 244 TRP A CZ2 1 
ATOM   1981 C CZ3 . TRP A 1 244 ? -42.35954 -20.90134 10.10978  1.000 17.84647 ? 244 TRP A CZ3 1 
ATOM   1982 C CH2 . TRP A 1 244 ? -42.21777 -21.84776 9.08148   1.000 19.40321 ? 244 TRP A CH2 1 
ATOM   1983 N N   . ALA A 1 245 ? -40.22381 -17.81025 12.73063  1.000 16.24338 ? 245 ALA A N   1 
ATOM   1984 C CA  . ALA A 1 245 ? -41.21262 -18.29365 13.67826  1.000 13.94471 ? 245 ALA A CA  1 
ATOM   1985 C C   . ALA A 1 245 ? -42.55379 -17.78501 13.18672  1.000 13.84591 ? 245 ALA A C   1 
ATOM   1986 O O   . ALA A 1 245 ? -42.67693 -16.61208 12.81830  1.000 16.69215 ? 245 ALA A O   1 
ATOM   1987 C CB  . ALA A 1 245 ? -40.95014 -17.78997 15.10117  1.000 14.37251 ? 245 ALA A CB  1 
ATOM   1988 N N   . ALA A 1 246 ? -43.53031 -18.66473 13.15736  1.000 13.23642 ? 246 ALA A N   1 
ATOM   1989 C CA  . ALA A 1 246 ? -44.83522 -18.37488 12.58213  1.000 16.50370 ? 246 ALA A CA  1 
ATOM   1990 C C   . ALA A 1 246 ? -45.92133 -18.74321 13.58327  1.000 17.88100 ? 246 ALA A C   1 
ATOM   1991 O O   . ALA A 1 246 ? -45.73331 -19.61118 14.43891  1.000 17.49194 ? 246 ALA A O   1 
ATOM   1992 C CB  . ALA A 1 246 ? -45.07130 -19.15370 11.27547  1.000 17.90321 ? 246 ALA A CB  1 
ATOM   1993 N N   . VAL A 1 247 ? -47.06372 -18.08638 13.45305  1.000 15.62911 ? 247 VAL A N   1 
ATOM   1994 C CA  . VAL A 1 247 ? -48.21556 -18.37500 14.30097  1.000 15.31225 ? 247 VAL A CA  1 
ATOM   1995 C C   . VAL A 1 247 ? -49.48202 -18.17857 13.47479  1.000 18.44916 ? 247 VAL A C   1 
ATOM   1996 O O   . VAL A 1 247 ? -49.55534 -17.27827 12.63584  1.000 16.23182 ? 247 VAL A O   1 
ATOM   1997 C CB  . VAL A 1 247 ? -48.15329 -17.49605 15.56464  1.000 18.26091 ? 247 VAL A CB  1 
ATOM   1998 C CG1 . VAL A 1 247 ? -48.51486 -16.08159 15.23957  1.000 16.83107 ? 247 VAL A CG1 1 
ATOM   1999 C CG2 . VAL A 1 247 ? -49.07435 -18.05264 16.65600  1.000 28.00179 ? 247 VAL A CG2 1 
ATOM   2000 N N   . VAL A 1 248 ? -50.46014 -19.06213 13.66587  1.000 17.91472 ? 248 VAL A N   1 
ATOM   2001 C CA  . VAL A 1 248 ? -51.76293 -18.91054 13.02182  1.000 18.99445 ? 248 VAL A CA  1 
ATOM   2002 C C   . VAL A 1 248 ? -52.67010 -18.15887 13.98582  1.000 22.16103 ? 248 VAL A C   1 
ATOM   2003 O O   . VAL A 1 248 ? -52.76926 -18.51511 15.16459  1.000 20.42786 ? 248 VAL A O   1 
ATOM   2004 C CB  . VAL A 1 248 ? -52.35505 -20.27635 12.63636  1.000 19.15621 ? 248 VAL A CB  1 
ATOM   2005 C CG1 . VAL A 1 248 ? -53.78244 -20.12435 12.09824  1.000 22.64275 ? 248 VAL A CG1 1 
ATOM   2006 C CG2 . VAL A 1 248 ? -51.45370 -20.96565 11.62960  1.000 21.02389 ? 248 VAL A CG2 1 
ATOM   2007 N N   . VAL A 1 249 ? -53.28856 -17.08675 13.50330  1.000 19.00366 ? 249 VAL A N   1 
ATOM   2008 C CA  . VAL A 1 249 ? -54.05758 -16.19681 14.36806  1.000 17.54117 ? 249 VAL A CA  1 
ATOM   2009 C C   . VAL A 1 249 ? -55.45325 -16.04591 13.78215  1.000 22.98036 ? 249 VAL A C   1 
ATOM   2010 O O   . VAL A 1 249 ? -55.67160 -16.25560 12.57265  1.000 19.44911 ? 249 VAL A O   1 
ATOM   2011 C CB  . VAL A 1 249 ? -53.37865 -14.81700 14.51477  1.000 19.33675 ? 249 VAL A CB  1 
ATOM   2012 C CG1 . VAL A 1 249 ? -51.93937 -14.99657 14.98160  1.000 22.18249 ? 249 VAL A CG1 1 
ATOM   2013 C CG2 . VAL A 1 249 ? -53.42535 -14.04955 13.18803  1.000 20.03792 ? 249 VAL A CG2 1 
ATOM   2014 N N   . PRO A 1 250 ? -56.42444 -15.69518 14.62112  1.000 20.59844 ? 250 PRO A N   1 
ATOM   2015 C CA  . PRO A 1 250 ? -57.75667 -15.36071 14.10353  1.000 24.13965 ? 250 PRO A CA  1 
ATOM   2016 C C   . PRO A 1 250 ? -57.70335 -14.09113 13.27471  1.000 21.69748 ? 250 PRO A C   1 
ATOM   2017 O O   . PRO A 1 250 ? -57.04563 -13.11381 13.64370  1.000 21.16658 ? 250 PRO A O   1 
ATOM   2018 C CB  . PRO A 1 250 ? -58.59670 -15.16129 15.37229  1.000 25.03625 ? 250 PRO A CB  1 
ATOM   2019 C CG  . PRO A 1 250 ? -57.87113 -15.92467 16.44153  1.000 21.12003 ? 250 PRO A CG  1 
ATOM   2020 C CD  . PRO A 1 250 ? -56.40592 -15.77263 16.09154  1.000 20.84463 ? 250 PRO A CD  1 
ATOM   2021 N N   . SER A 1 251 ? -58.38075 -14.12869 12.12924  1.000 26.23953 ? 251 SER A N   1 
ATOM   2022 C CA  . SER A 1 251 ? -58.40766 -12.98938 11.22574  1.000 24.53159 ? 251 SER A CA  1 
ATOM   2023 C C   . SER A 1 251 ? -58.93648 -11.76834 11.95928  1.000 27.84855 ? 251 SER A C   1 
ATOM   2024 O O   . SER A 1 251 ? -60.02670 -11.80655 12.53820  1.000 24.18861 ? 251 SER A O   1 
ATOM   2025 C CB  . SER A 1 251 ? -59.28980 -13.30634 10.01865  1.000 33.48596 ? 251 SER A CB  1 
ATOM   2026 O OG  . SER A 1 251 ? -58.52411 -13.80683 8.94183   1.000 37.78762 ? 251 SER A OG  1 
ATOM   2027 N N   . GLY A 1 252 ? -58.16821 -10.68598 11.93712  1.000 25.81346 ? 252 GLY A N   1 
ATOM   2028 C CA  . GLY A 1 252 ? -58.55332 -9.46172  12.60905  1.000 23.29879 ? 252 GLY A CA  1 
ATOM   2029 C C   . GLY A 1 252 ? -57.91952 -9.25278  13.96799  1.000 27.00402 ? 252 GLY A C   1 
ATOM   2030 O O   . GLY A 1 252 ? -58.02196 -8.15009  14.51532  1.000 30.47532 ? 252 GLY A O   1 
ATOM   2031 N N   . GLU A 1 253 ? -57.27799 -10.27435 14.53788  1.000 21.12568 ? 253 GLU A N   1 
ATOM   2032 C CA  . GLU A 1 253 ? -56.63463 -10.14960 15.83660  1.000 21.11891 ? 253 GLU A CA  1 
ATOM   2033 C C   . GLU A 1 253 ? -55.11764 -10.08625 15.71886  1.000 24.53016 ? 253 GLU A C   1 
ATOM   2034 O O   . GLU A 1 253 ? -54.42082 -10.33366 16.70270  1.000 18.71358 ? 253 GLU A O   1 
ATOM   2035 C CB  . GLU A 1 253 ? -57.05987 -11.30105 16.75355  1.000 21.27034 ? 253 GLU A CB  1 
ATOM   2036 C CG  . GLU A 1 253 ? -58.58050 -11.43790 16.83409  1.000 26.46657 ? 253 GLU A CG  1 
ATOM   2037 C CD  . GLU A 1 253 ? -59.18729 -10.29503 17.64164  1.000 26.58092 ? 253 GLU A CD  1 
ATOM   2038 O OE1 . GLU A 1 253 ? -58.40503 -9.57174  18.29749  1.000 25.69463 ? 253 GLU A OE1 1 
ATOM   2039 O OE2 . GLU A 1 253 ? -60.42530 -10.06102 17.56920  1.000 28.79931 ? 253 GLU A OE2 1 
ATOM   2040 N N   . GLU A 1 254 ? -54.60016 -9.77211  14.52276  1.000 19.29878 ? 254 GLU A N   1 
ATOM   2041 C CA  . GLU A 1 254 ? -53.15472 -9.76856  14.29553  1.000 17.64009 ? 254 GLU A CA  1 
ATOM   2042 C C   . GLU A 1 254 ? -52.43549 -8.84768  15.27292  1.000 18.98283 ? 254 GLU A C   1 
ATOM   2043 O O   . GLU A 1 254 ? -51.32680 -9.14946  15.72064  1.000 16.59016 ? 254 GLU A O   1 
ATOM   2044 C CB  . GLU A 1 254 ? -52.86566 -9.35045  12.84916  1.000 19.66434 ? 254 GLU A CB  1 
ATOM   2045 C CG  . GLU A 1 254 ? -53.13236 -10.45787 11.85351  1.000 21.37885 ? 254 GLU A CG  1 
ATOM   2046 C CD  . GLU A 1 254 ? -54.56840 -10.45215 11.34194  1.000 26.12988 ? 254 GLU A CD  1 
ATOM   2047 O OE1 . GLU A 1 254 ? -55.42312 -9.76351  11.95232  1.000 23.72487 ? 254 GLU A OE1 1 
ATOM   2048 O OE2 . GLU A 1 254 ? -54.85058 -11.17602 10.36318  1.000 26.10966 ? 254 GLU A OE2 1 
ATOM   2049 N N   . GLN A 1 255 ? -53.06010 -7.72970  15.63669  1.000 18.31483 ? 255 GLN A N   1 
ATOM   2050 C CA  . GLN A 1 255 ? -52.35868 -6.71206  16.39932  1.000 17.77301 ? 255 GLN A CA  1 
ATOM   2051 C C   . GLN A 1 255 ? -52.09638 -7.10464  17.85524  1.000 20.98568 ? 255 GLN A C   1 
ATOM   2052 O O   . GLN A 1 255 ? -51.30785 -6.42666  18.51499  1.000 25.31512 ? 255 GLN A O   1 
ATOM   2053 C CB  . GLN A 1 255 ? -53.11824 -5.37217  16.37459  1.000 22.91503 ? 255 GLN A CB  1 
ATOM   2054 C CG  . GLN A 1 255 ? -54.62373 -5.39869  16.75679  1.000 28.90472 ? 255 GLN A CG  1 
ATOM   2055 C CD  . GLN A 1 255 ? -55.53556 -6.24367  15.84037  1.000 36.07411 ? 255 GLN A CD  1 
ATOM   2056 O OE1 . GLN A 1 255 ? -55.21530 -6.52231  14.66241  1.000 33.06582 ? 255 GLN A OE1 1 
ATOM   2057 N NE2 . GLN A 1 255 ? -56.66452 -6.68800  16.40146  1.000 35.03117 ? 255 GLN A NE2 1 
ATOM   2058 N N   . ARG A 1 256 ? -52.71672 -8.16097  18.38524  1.000 16.26793 ? 256 ARG A N   1 
ATOM   2059 C CA  . ARG A 1 256 ? -52.38751 -8.57509  19.74488  1.000 19.45657 ? 256 ARG A CA  1 
ATOM   2060 C C   . ARG A 1 256 ? -51.22100 -9.54845  19.82176  1.000 21.85917 ? 256 ARG A C   1 
ATOM   2061 O O   . ARG A 1 256 ? -50.83220 -9.93495  20.92810  1.000 24.86525 ? 256 ARG A O   1 
ATOM   2062 C CB  . ARG A 1 256 ? -53.61835 -9.15681  20.42482  1.000 24.93935 ? 256 ARG A CB  1 
ATOM   2063 C CG  . ARG A 1 256 ? -54.22190 -10.30455 19.72761  1.000 25.64001 ? 256 ARG A CG  1 
ATOM   2064 C CD  . ARG A 1 256 ? -55.50283 -10.65468 20.45222  1.000 29.99288 ? 256 ARG A CD  1 
ATOM   2065 N NE  . ARG A 1 256 ? -56.07888 -9.40970  20.92580  1.000 29.44952 ? 256 ARG A NE  1 
ATOM   2066 C CZ  . ARG A 1 256 ? -57.31092 -9.25838  21.37888  1.000 27.66927 ? 256 ARG A CZ  1 
ATOM   2067 N NH1 . ARG A 1 256 ? -58.27672 -10.07497 21.00845  1.000 30.31973 ? 256 ARG A NH1 1 
ATOM   2068 N NH2 . ARG A 1 256 ? -57.57404 -8.26162  22.22512  1.000 25.25556 ? 256 ARG A NH2 1 
ATOM   2069 N N   . TYR A 1 257 ? -50.62085 -9.91646  18.69078  1.000 20.55313 ? 257 TYR A N   1 
ATOM   2070 C CA  . TYR A 1 257 ? -49.47927 -10.82517 18.68477  1.000 20.98441 ? 257 TYR A CA  1 
ATOM   2071 C C   . TYR A 1 257 ? -48.19387 -10.02602 18.47452  1.000 19.15621 ? 257 TYR A C   1 
ATOM   2072 O O   . TYR A 1 257 ? -48.14104 -9.13126  17.62436  1.000 16.71235 ? 257 TYR A O   1 
ATOM   2073 C CB  . TYR A 1 257 ? -49.64508 -11.88023 17.57997  1.000 17.97191 ? 257 TYR A CB  1 
ATOM   2074 C CG  . TYR A 1 257 ? -50.82435 -12.80621 17.82535  1.000 18.79716 ? 257 TYR A CG  1 
ATOM   2075 C CD1 . TYR A 1 257 ? -52.12534 -12.38453 17.55331  1.000 22.18231 ? 257 TYR A CD1 1 
ATOM   2076 C CD2 . TYR A 1 257 ? -50.64586 -14.09035 18.31691  1.000 18.82335 ? 257 TYR A CD2 1 
ATOM   2077 C CE1 . TYR A 1 257 ? -53.21148 -13.20770 17.76881  1.000 18.88512 ? 257 TYR A CE1 1 
ATOM   2078 C CE2 . TYR A 1 257 ? -51.74776 -14.93596 18.54422  1.000 19.06419 ? 257 TYR A CE2 1 
ATOM   2079 C CZ  . TYR A 1 257 ? -53.01764 -14.48488 18.25866  1.000 20.03990 ? 257 TYR A CZ  1 
ATOM   2080 O OH  . TYR A 1 257 ? -54.11647 -15.29316 18.47200  1.000 20.10900 ? 257 TYR A OH  1 
ATOM   2081 N N   . THR A 1 258 ? -47.15818 -10.33225 19.25440  1.000 18.14116 ? 258 THR A N   1 
ATOM   2082 C CA  . THR A 1 258 ? -45.86676 -9.68789  19.04612  1.000 17.32916 ? 258 THR A CA  1 
ATOM   2083 C C   . THR A 1 258 ? -44.77010 -10.74043 18.98278  1.000 16.96457 ? 258 THR A C   1 
ATOM   2084 O O   . THR A 1 258 ? -44.80661 -11.74076 19.70332  1.000 15.65871 ? 258 THR A O   1 
ATOM   2085 C CB  . THR A 1 258 ? -45.54362 -8.67416  20.14251  1.000 19.47620 ? 258 THR A CB  1 
ATOM   2086 O OG1 . THR A 1 258 ? -45.80508 -9.26460  21.41194  1.000 20.34410 ? 258 THR A OG1 1 
ATOM   2087 C CG2 . THR A 1 258 ? -46.39013 -7.43044  20.00838  1.000 19.63519 ? 258 THR A CG2 1 
ATOM   2088 N N   . CYS A 1 259 ? -43.82985 -10.53613 18.07473  1.000 19.34592 ? 259 CYS A N   1 
ATOM   2089 C CA  . CYS A 1 259 ? -42.66693 -11.39637 17.93308  1.000 20.38860 ? 259 CYS A CA  1 
ATOM   2090 C C   . CYS A 1 259 ? -41.48049 -10.70102 18.58067  1.000 20.39908 ? 259 CYS A C   1 
ATOM   2091 O O   . CYS A 1 259 ? -41.26002 -9.51049  18.35972  1.000 21.16720 ? 259 CYS A O   1 
ATOM   2092 C CB  . CYS A 1 259 ? -42.37412 -11.68915 16.45966  1.000 23.70824 ? 259 CYS A CB  1 
ATOM   2093 S SG  . CYS A 1 259 ? -40.77447 -12.49716 16.18972  1.000 25.75231 ? 259 CYS A SG  1 
ATOM   2094 N N   . HIS A 1 260 ? -40.73765 -11.43385 19.39508  1.000 18.28217 ? 260 HIS A N   1 
ATOM   2095 C CA  . HIS A 1 260 ? -39.63406 -10.86428 20.15295  1.000 23.97483 ? 260 HIS A CA  1 
ATOM   2096 C C   . HIS A 1 260 ? -38.35522 -11.56294 19.73398  1.000 21.77778 ? 260 HIS A C   1 
ATOM   2097 O O   . HIS A 1 260 ? -38.28709 -12.79441 19.77291  1.000 18.11993 ? 260 HIS A O   1 
ATOM   2098 C CB  . HIS A 1 260 ? -39.86672 -11.01021 21.65328  1.000 21.43601 ? 260 HIS A CB  1 
ATOM   2099 C CG  . HIS A 1 260 ? -41.12615 -10.35182 22.12843  1.000 25.63750 ? 260 HIS A CG  1 
ATOM   2100 N ND1 . HIS A 1 260 ? -41.12501 -9.19352  22.87632  1.000 29.40063 ? 260 HIS A ND1 1 
ATOM   2101 C CD2 . HIS A 1 260 ? -42.43018 -10.66215 21.91819  1.000 24.21572 ? 260 HIS A CD2 1 
ATOM   2102 C CE1 . HIS A 1 260 ? -42.37251 -8.84124  23.14177  1.000 26.95461 ? 260 HIS A CE1 1 
ATOM   2103 N NE2 . HIS A 1 260 ? -43.18300 -9.71067  22.56464  1.000 25.50184 ? 260 HIS A NE2 1 
ATOM   2104 N N   . VAL A 1 261 ? -37.34763 -10.77025 19.37397  1.000 22.54157 ? 261 VAL A N   1 
ATOM   2105 C CA  . VAL A 1 261 ? -36.10830 -11.24956 18.76966  1.000 23.67365 ? 261 VAL A CA  1 
ATOM   2106 C C   . VAL A 1 261 ? -34.95536 -10.84996 19.67519  1.000 18.72010 ? 261 VAL A C   1 
ATOM   2107 O O   . VAL A 1 261 ? -34.71533 -9.65328  19.88104  1.000 20.85734 ? 261 VAL A O   1 
ATOM   2108 C CB  . VAL A 1 261 ? -35.89362 -10.65597 17.36593  1.000 16.88462 ? 261 VAL A CB  1 
ATOM   2109 C CG1 . VAL A 1 261 ? -34.69994 -11.31621 16.68092  1.000 24.38469 ? 261 VAL A CG1 1 
ATOM   2110 C CG2 . VAL A 1 261 ? -37.15190 -10.76277 16.52337  1.000 19.88144 ? 261 VAL A CG2 1 
ATOM   2111 N N   . GLN A 1 262 ? -34.22161 -11.83684 20.18203  1.000 18.13564 ? 262 GLN A N   1 
ATOM   2112 C CA  . GLN A 1 262 ? -33.04630 -11.58981 21.00673  1.000 20.96306 ? 262 GLN A CA  1 
ATOM   2113 C C   . GLN A 1 262 ? -31.80981 -12.16837 20.33055  1.000 17.27481 ? 262 GLN A C   1 
ATOM   2114 O O   . GLN A 1 262 ? -31.81004 -13.33439 19.92511  1.000 14.55560 ? 262 GLN A O   1 
ATOM   2115 C CB  . GLN A 1 262 ? -33.21201 -12.19173 22.40663  1.000 26.81726 ? 262 GLN A CB  1 
ATOM   2116 C CG  . GLN A 1 262 ? -34.65393 -12.29552 22.86634  1.000 29.64838 ? 262 GLN A CG  1 
ATOM   2117 C CD  . GLN A 1 262 ? -34.77179 -12.92603 24.23098  1.000 27.11360 ? 262 GLN A CD  1 
ATOM   2118 O OE1 . GLN A 1 262 ? -33.91169 -12.73616 25.09118  1.000 35.90887 ? 262 GLN A OE1 1 
ATOM   2119 N NE2 . GLN A 1 262 ? -35.80680 -13.72802 24.42012  1.000 28.47851 ? 262 GLN A NE2 1 
ATOM   2120 N N   . HIS A 1 263 ? -30.76152 -11.35353 20.22805  1.000 20.32279 ? 263 HIS A N   1 
ATOM   2121 C CA  . HIS A 1 263 ? -29.51207 -11.74802 19.59214  1.000 20.23575 ? 263 HIS A CA  1 
ATOM   2122 C C   . HIS A 1 263 ? -28.37332 -10.92930 20.18416  1.000 24.37984 ? 263 HIS A C   1 
ATOM   2123 O O   . HIS A 1 263 ? -28.56396 -9.77575  20.57706  1.000 24.69145 ? 263 HIS A O   1 
ATOM   2124 C CB  . HIS A 1 263 ? -29.56550 -11.54785 18.07016  1.000 21.32482 ? 263 HIS A CB  1 
ATOM   2125 C CG  . HIS A 1 263 ? -28.38132 -12.11327 17.35402  1.000 20.97032 ? 263 HIS A CG  1 
ATOM   2126 N ND1 . HIS A 1 263 ? -27.25279 -11.36911 17.08804  1.000 21.42574 ? 263 HIS A ND1 1 
ATOM   2127 C CD2 . HIS A 1 263 ? -28.14451 -13.34805 16.85423  1.000 18.30205 ? 263 HIS A CD2 1 
ATOM   2128 C CE1 . HIS A 1 263 ? -26.37513 -12.11543 16.44183  1.000 20.52706 ? 263 HIS A CE1 1 
ATOM   2129 N NE2 . HIS A 1 263 ? -26.89047 -13.32174 16.28574  1.000 20.80920 ? 263 HIS A NE2 1 
ATOM   2130 N N   . GLU A 1 264 ? -27.18523 -11.54333 20.23346  1.000 25.23968 ? 264 GLU A N   1 
ATOM   2131 C CA  . GLU A 1 264 ? -25.98523 -10.86464 20.72045  1.000 25.76167 ? 264 GLU A CA  1 
ATOM   2132 C C   . GLU A 1 264 ? -25.82289 -9.47899  20.12098  1.000 27.19190 ? 264 GLU A C   1 
ATOM   2133 O O   . GLU A 1 264 ? -25.46960 -8.52695  20.82516  1.000 27.78470 ? 264 GLU A O   1 
ATOM   2134 C CB  . GLU A 1 264 ? -24.73718 -11.67325 20.38025  1.000 32.23313 ? 264 GLU A CB  1 
ATOM   2135 C CG  . GLU A 1 264 ? -24.35952 -12.68316 21.40792  1.000 35.82846 ? 264 GLU A CG  1 
ATOM   2136 C CD  . GLU A 1 264 ? -23.27062 -13.60492 20.90400  1.000 39.35675 ? 264 GLU A CD  1 
ATOM   2137 O OE1 . GLU A 1 264 ? -22.17695 -13.08529 20.54791  1.000 34.21920 ? 264 GLU A OE1 1 
ATOM   2138 O OE2 . GLU A 1 264 ? -23.52766 -14.82996 20.83957  1.000 39.69480 ? 264 GLU A OE2 1 
ATOM   2139 N N   . GLY A 1 265 ? -26.02743 -9.35642  18.80804  1.000 27.46784 ? 265 GLY A N   1 
ATOM   2140 C CA  . GLY A 1 265 ? -25.77074 -8.10859  18.10824  1.000 26.30597 ? 265 GLY A CA  1 
ATOM   2141 C C   . GLY A 1 265 ? -26.78440 -7.01269  18.36199  1.000 28.92805 ? 265 GLY A C   1 
ATOM   2142 O O   . GLY A 1 265 ? -26.57522 -5.88524  17.89869  1.000 29.85966 ? 265 GLY A O   1 
ATOM   2143 N N   . LEU A 1 266 ? -27.86735 -7.30699  19.08111  1.000 26.89721 ? 266 LEU A N   1 
ATOM   2144 C CA  . LEU A 1 266 ? -28.89471 -6.31166  19.33036  1.000 33.95035 ? 266 LEU A CA  1 
ATOM   2145 C C   . LEU A 1 266 ? -28.70341 -5.72678  20.71806  1.000 38.17865 ? 266 LEU A C   1 
ATOM   2146 O O   . LEU A 1 266 ? -28.83564 -6.46389  21.71583  1.000 32.24803 ? 266 LEU A O   1 
ATOM   2147 C CB  . LEU A 1 266 ? -30.29523 -6.90992  19.21110  1.000 28.00596 ? 266 LEU A CB  1 
ATOM   2148 C CG  . LEU A 1 266 ? -30.79819 -7.45060  17.87884  1.000 26.84654 ? 266 LEU A CG  1 
ATOM   2149 C CD1 . LEU A 1 266 ? -32.07567 -8.26462  18.10797  1.000 23.30736 ? 266 LEU A CD1 1 
ATOM   2150 C CD2 . LEU A 1 266 ? -31.01734 -6.32309  16.87505  1.000 26.11705 ? 266 LEU A CD2 1 
ATOM   2151 N N   . PRO A 1 267 ? -28.45782 -4.41838  20.84350  1.000 31.90116 ? 267 PRO A N   1 
ATOM   2152 C CA  . PRO A 1 267 ? -28.33019 -3.83401  22.18374  1.000 39.53148 ? 267 PRO A CA  1 
ATOM   2153 C C   . PRO A 1 267 ? -29.63342 -3.82399  22.96377  1.000 37.92765 ? 267 PRO A C   1 
ATOM   2154 O O   . PRO A 1 267 ? -29.59893 -3.57379  24.17379  1.000 42.65630 ? 267 PRO A O   1 
ATOM   2155 C CB  . PRO A 1 267 ? -27.82983 -2.41697  21.89072  1.000 39.47600 ? 267 PRO A CB  1 
ATOM   2156 C CG  . PRO A 1 267 ? -28.40443 -2.08595  20.49147  1.000 38.56444 ? 267 PRO A CG  1 
ATOM   2157 C CD  . PRO A 1 267 ? -28.86881 -3.39860  19.85771  1.000 36.35054 ? 267 PRO A CD  1 
ATOM   2158 N N   . LYS A 1 268 ? -30.76936 -4.11249  22.31308  1.000 36.14800 ? 268 LYS A N   1 
ATOM   2159 C CA  . LYS A 1 268 ? -32.11881 -4.10531  22.87273  1.000 36.73270 ? 268 LYS A CA  1 
ATOM   2160 C C   . LYS A 1 268 ? -32.84048 -5.21048  22.11746  1.000 32.27981 ? 268 LYS A C   1 
ATOM   2161 O O   . LYS A 1 268 ? -32.78918 -5.21295  20.87646  1.000 29.58503 ? 268 LYS A O   1 
ATOM   2162 C CB  . LYS A 1 268 ? -32.86523 -2.78432  22.65285  1.000 37.00819 ? 268 LYS A CB  1 
ATOM   2163 C CG  . LYS A 1 268 ? -32.52251 -1.61792  23.56441  1.000 47.16887 ? 268 LYS A CG  1 
ATOM   2164 C CD  . LYS A 1 268 ? -33.55575 -0.49824  23.34813  1.000 52.16696 ? 268 LYS A CD  1 
ATOM   2165 C CE  . LYS A 1 268 ? -33.41189 0.64103   24.34695  1.000 51.65754 ? 268 LYS A CE  1 
ATOM   2166 N NZ  . LYS A 1 268 ? -32.35208 1.60415   23.90830  1.000 53.11291 ? 268 LYS A NZ  1 
ATOM   2167 N N   . PRO A 1 269 ? -33.53092 -6.12481  22.80305  1.000 28.30400 ? 269 PRO A N   1 
ATOM   2168 C CA  . PRO A 1 269 ? -34.39471 -7.07599  22.08840  1.000 30.36373 ? 269 PRO A CA  1 
ATOM   2169 C C   . PRO A 1 269 ? -35.40176 -6.34714  21.20554  1.000 27.97302 ? 269 PRO A C   1 
ATOM   2170 O O   . PRO A 1 269 ? -35.93476 -5.29979  21.57304  1.000 27.44492 ? 269 PRO A O   1 
ATOM   2171 C CB  . PRO A 1 269 ? -35.08641 -7.84589  23.21949  1.000 25.68665 ? 269 PRO A CB  1 
ATOM   2172 C CG  . PRO A 1 269 ? -34.15183 -7.74083  24.36466  1.000 27.95054 ? 269 PRO A CG  1 
ATOM   2173 C CD  . PRO A 1 269 ? -33.53033 -6.36855  24.25382  1.000 26.47976 ? 269 PRO A CD  1 
ATOM   2174 N N   . LEU A 1 270 ? -35.63527 -6.89546  20.01652  1.000 28.74369 ? 270 LEU A N   1 
ATOM   2175 C CA  . LEU A 1 270 ? -36.53084 -6.28505  19.04662  1.000 25.59793 ? 270 LEU A CA  1 
ATOM   2176 C C   . LEU A 1 270 ? -37.95477 -6.77833  19.29919  1.000 26.24508 ? 270 LEU A C   1 
ATOM   2177 O O   . LEU A 1 270 ? -38.16648 -7.89594  19.77422  1.000 27.74037 ? 270 LEU A O   1 
ATOM   2178 C CB  . LEU A 1 270 ? -36.08244 -6.64222  17.62864  1.000 23.25802 ? 270 LEU A CB  1 
ATOM   2179 C CG  . LEU A 1 270 ? -35.03552 -5.70056  17.03675  1.000 28.29976 ? 270 LEU A CG  1 
ATOM   2180 C CD1 . LEU A 1 270 ? -34.74934 -6.02904  15.58160  1.000 33.47561 ? 270 LEU A CD1 1 
ATOM   2181 C CD2 . LEU A 1 270 ? -35.41541 -4.23953  17.20968  1.000 29.59709 ? 270 LEU A CD2 1 
ATOM   2182 N N   . THR A 1 271 ? -38.93405 -5.92161  19.01882  1.000 28.14489 ? 271 THR A N   1 
ATOM   2183 C CA  . THR A 1 271 ? -40.34676 -6.28014  19.12123  1.000 23.15054 ? 271 THR A CA  1 
ATOM   2184 C C   . THR A 1 271 ? -41.02243 -5.94495  17.80059  1.000 27.64284 ? 271 THR A C   1 
ATOM   2185 O O   . THR A 1 271 ? -40.99645 -4.78741  17.36675  1.000 31.44280 ? 271 THR A O   1 
ATOM   2186 C CB  . THR A 1 271 ? -41.04948 -5.55008  20.27027  1.000 25.48905 ? 271 THR A CB  1 
ATOM   2187 O OG1 . THR A 1 271 ? -40.53465 -5.99443  21.52857  1.000 26.62056 ? 271 THR A OG1 1 
ATOM   2188 C CG2 . THR A 1 271 ? -42.54499 -5.84352  20.24252  1.000 23.81343 ? 271 THR A CG2 1 
ATOM   2189 N N   . LEU A 1 272 ? -41.61735 -6.94678  17.15609  1.000 22.52856 ? 272 LEU A N   1 
ATOM   2190 C CA  . LEU A 1 272 ? -42.31557 -6.73949  15.89544  1.000 21.43342 ? 272 LEU A CA  1 
ATOM   2191 C C   . LEU A 1 272 ? -43.80339 -6.99514  16.08896  1.000 20.94612 ? 272 LEU A C   1 
ATOM   2192 O O   . LEU A 1 272 ? -44.19397 -7.87626  16.86360  1.000 17.99410 ? 272 LEU A O   1 
ATOM   2193 C CB  . LEU A 1 272 ? -41.76360 -7.65548  14.80115  1.000 20.83108 ? 272 LEU A CB  1 
ATOM   2194 C CG  . LEU A 1 272 ? -40.35790 -7.33036  14.28761  1.000 22.64317 ? 272 LEU A CG  1 
ATOM   2195 C CD1 . LEU A 1 272 ? -39.28905 -7.98843  15.14657  1.000 24.09421 ? 272 LEU A CD1 1 
ATOM   2196 C CD2 . LEU A 1 272 ? -40.24355 -7.84382  12.85076  1.000 23.83456 ? 272 LEU A CD2 1 
ATOM   2197 N N   . ARG A 1 273 ? -44.62172 -6.22333  15.37285  1.000 18.32460 ? 273 ARG A N   1 
ATOM   2198 C CA  . ARG A 1 273 ? -46.07804 -6.30106  15.45050  1.000 21.20332 ? 273 ARG A CA  1 
ATOM   2199 C C   . ARG A 1 273 ? -46.64569 -5.90225  14.09349  1.000 25.14873 ? 273 ARG A C   1 
ATOM   2200 O O   . ARG A 1 273 ? -46.26679 -4.86009  13.55157  1.000 23.04887 ? 273 ARG A O   1 
ATOM   2201 C CB  . ARG A 1 273 ? -46.64047 -5.37603  16.54492  1.000 23.47878 ? 273 ARG A CB  1 
ATOM   2202 C CG  . ARG A 1 273 ? -48.11908 -5.63119  16.87327  1.000 21.96982 ? 273 ARG A CG  1 
ATOM   2203 C CD  . ARG A 1 273 ? -48.76122 -4.53834  17.75330  1.000 27.16749 ? 273 ARG A CD  1 
ATOM   2204 N NE  . ARG A 1 273 ? -48.00146 -4.23437  18.96192  1.000 30.84887 ? 273 ARG A NE  1 
ATOM   2205 C CZ  . ARG A 1 273 ? -48.26341 -4.74231  20.16250  1.000 33.26738 ? 273 ARG A CZ  1 
ATOM   2206 N NH1 . ARG A 1 273 ? -49.25429 -5.60352  20.35154  1.000 31.12152 ? 273 ARG A NH1 1 
ATOM   2207 N NH2 . ARG A 1 273 ? -47.49000 -4.40678  21.19590  1.000 33.21180 ? 273 ARG A NH2 1 
ATOM   2208 N N   . TRP A 1 274 ? -47.52579 -6.73571  13.53781  1.000 20.79582 ? 274 TRP A N   1 
ATOM   2209 C CA  . TRP A 1 274 ? -48.15031 -6.43940  12.24163  1.000 24.50084 ? 274 TRP A CA  1 
ATOM   2210 C C   . TRP A 1 274 ? -49.06786 -5.21229  12.31336  1.000 25.65439 ? 274 TRP A C   1 
ATOM   2211 O O   . TRP A 1 274 ? -49.84999 -5.09608  13.26859  1.000 28.74646 ? 274 TRP A O   1 
ATOM   2212 C CB  . TRP A 1 274 ? -48.95899 -7.63404  11.74198  1.000 18.95569 ? 274 TRP A CB  1 
ATOM   2213 C CG  . TRP A 1 274 ? -49.44933 -7.45174  10.34306  1.000 21.16543 ? 274 TRP A CG  1 
ATOM   2214 C CD1 . TRP A 1 274 ? -50.73090 -7.18437  9.94518   1.000 22.55295 ? 274 TRP A CD1 1 
ATOM   2215 C CD2 . TRP A 1 274 ? -48.66312 -7.53192  9.14838   1.000 19.14581 ? 274 TRP A CD2 1 
ATOM   2216 N NE1 . TRP A 1 274 ? -50.78461 -7.08075  8.57488   1.000 22.54191 ? 274 TRP A NE1 1 
ATOM   2217 C CE2 . TRP A 1 274 ? -49.52870 -7.29797  8.06136   1.000 19.20060 ? 274 TRP A CE2 1 
ATOM   2218 C CE3 . TRP A 1 274 ? -47.30414 -7.76068  8.89707   1.000 17.87497 ? 274 TRP A CE3 1 
ATOM   2219 C CZ2 . TRP A 1 274 ? -49.08503 -7.29466  6.74087   1.000 18.86800 ? 274 TRP A CZ2 1 
ATOM   2220 C CZ3 . TRP A 1 274 ? -46.86215 -7.78058  7.59113   1.000 18.21758 ? 274 TRP A CZ3 1 
ATOM   2221 C CH2 . TRP A 1 274 ? -47.74657 -7.53929  6.51998   1.000 19.98771 ? 274 TRP A CH2 1 
ATOM   2222 N N   . ILE B 2 1   ? -29.32969 -46.47792 15.26273  1.000 41.57121 ? 1   ILE B N   1 
ATOM   2223 C CA  . ILE B 2 1   ? -30.51963 -45.64300 15.10578  1.000 43.77858 ? 1   ILE B CA  1 
ATOM   2224 C C   . ILE B 2 1   ? -30.50318 -44.95445 13.74737  1.000 41.82070 ? 1   ILE B C   1 
ATOM   2225 O O   . ILE B 2 1   ? -29.43690 -44.75005 13.15629  1.000 41.59545 ? 1   ILE B O   1 
ATOM   2226 C CB  . ILE B 2 1   ? -30.63056 -44.59507 16.23759  1.000 38.51324 ? 1   ILE B CB  1 
ATOM   2227 C CG1 . ILE B 2 1   ? -32.03328 -43.95189 16.27607  1.000 44.62617 ? 1   ILE B CG1 1 
ATOM   2228 C CG2 . ILE B 2 1   ? -29.52546 -43.53156 16.08537  1.000 37.05980 ? 1   ILE B CG2 1 
ATOM   2229 C CD1 . ILE B 2 1   ? -33.21138 -44.92815 16.08222  1.000 43.48534 ? 1   ILE B CD1 1 
ATOM   2230 N N   . GLN B 2 2   ? -31.69840 -44.60443 13.26484  1.000 38.16469 ? 2   GLN B N   1 
ATOM   2231 C CA  . GLN B 2 2   ? -31.89150 -43.80868 12.06400  1.000 32.41883 ? 2   GLN B CA  1 
ATOM   2232 C C   . GLN B 2 2   ? -32.81742 -42.63763 12.36860  1.000 29.26734 ? 2   GLN B C   1 
ATOM   2233 O O   . GLN B 2 2   ? -33.83637 -42.80547 13.04631  1.000 33.53935 ? 2   GLN B O   1 
ATOM   2234 C CB  . GLN B 2 2   ? -32.48025 -44.64710 10.94355  1.000 34.27577 ? 2   GLN B CB  1 
ATOM   2235 C CG  . GLN B 2 2   ? -31.70156 -45.89860 10.62325  1.000 38.27374 ? 2   GLN B CG  1 
ATOM   2236 C CD  . GLN B 2 2   ? -32.35228 -46.68383 9.50207   1.000 44.34880 ? 2   GLN B CD  1 
ATOM   2237 O OE1 . GLN B 2 2   ? -33.55937 -46.52962 9.22731   1.000 35.42625 ? 2   GLN B OE1 1 
ATOM   2238 N NE2 . GLN B 2 2   ? -31.55601 -47.50861 8.82372   1.000 37.54119 ? 2   GLN B NE2 1 
ATOM   2239 N N   . ARG B 2 3   ? -32.45398 -41.45380 11.86835  1.000 19.13227 ? 3   ARG B N   1 
ATOM   2240 C CA  . ARG B 2 3   ? -33.24160 -40.23241 12.00717  1.000 21.33355 ? 3   ARG B CA  1 
ATOM   2241 C C   . ARG B 2 3   ? -33.46434 -39.62175 10.63349  1.000 20.50339 ? 3   ARG B C   1 
ATOM   2242 O O   . ARG B 2 3   ? -32.51344 -39.50143 9.85647   1.000 17.90474 ? 3   ARG B O   1 
ATOM   2243 C CB  . ARG B 2 3   ? -32.55469 -39.21022 12.92432  1.000 23.91337 ? 3   ARG B CB  1 
ATOM   2244 C CG  . ARG B 2 3   ? -32.24360 -39.75106 14.32195  1.000 29.77366 ? 3   ARG B CG  1 
ATOM   2245 C CD  . ARG B 2 3   ? -31.41916 -38.75706 15.11430  1.000 32.06739 ? 3   ARG B CD  1 
ATOM   2246 N NE  . ARG B 2 3   ? -30.08778 -39.28646 15.36379  1.000 37.88727 ? 3   ARG B NE  1 
ATOM   2247 C CZ  . ARG B 2 3   ? -29.20076 -38.74175 16.18300  1.000 35.81391 ? 3   ARG B CZ  1 
ATOM   2248 N NH1 . ARG B 2 3   ? -29.49892 -37.67249 16.91144  1.000 31.79932 ? 3   ARG B NH1 1 
ATOM   2249 N NH2 . ARG B 2 3   ? -27.97881 -39.27459 16.26017  1.000 29.01587 ? 3   ARG B NH2 1 
ATOM   2250 N N   . THR B 2 4   ? -34.75552 -39.24157 10.32047  1.000 18.85648 ? 4   THR B N   1 
ATOM   2251 C CA  . THR B 2 4   ? -35.07038 -38.67185 9.01335   1.000 19.55125 ? 4   THR B CA  1 
ATOM   2252 C C   . THR B 2 4   ? -34.56812 -37.24174 8.94825   1.000 19.70891 ? 4   THR B C   1 
ATOM   2253 O O   . THR B 2 4   ? -34.64911 -36.50730 9.93596   1.000 17.68285 ? 4   THR B O   1 
ATOM   2254 C CB  . THR B 2 4   ? -36.57241 -38.60938 8.74628   1.000 21.59656 ? 4   THR B CB  1 
ATOM   2255 O OG1 . THR B 2 4   ? -37.24930 -38.24399 9.94928   1.000 25.59974 ? 4   THR B OG1 1 
ATOM   2256 C CG2 . THR B 2 4   ? -37.11698 -39.90591 8.27436   1.000 26.43095 ? 4   THR B CG2 1 
ATOM   2257 N N   . PRO B 2 5   ? -34.14147 -36.80182 7.77222   1.000 19.18943 ? 5   PRO B N   1 
ATOM   2258 C CA  . PRO B 2 5   ? -33.68101 -35.41957 7.63241   1.000 19.33823 ? 5   PRO B CA  1 
ATOM   2259 C C   . PRO B 2 5   ? -34.84439 -34.45115 7.70579   1.000 21.45332 ? 5   PRO B C   1 
ATOM   2260 O O   . PRO B 2 5   ? -35.93108 -34.71297 7.18258   1.000 18.67127 ? 5   PRO B O   1 
ATOM   2261 C CB  . PRO B 2 5   ? -33.02374 -35.40236 6.24503   1.000 18.24352 ? 5   PRO B CB  1 
ATOM   2262 C CG  . PRO B 2 5   ? -33.68423 -36.50814 5.50724   1.000 25.08121 ? 5   PRO B CG  1 
ATOM   2263 C CD  . PRO B 2 5   ? -33.97875 -37.57643 6.52723   1.000 21.76242 ? 5   PRO B CD  1 
ATOM   2264 N N   . LYS B 2 6   ? -34.61639 -33.33824 8.38696   1.000 17.51929 ? 6   LYS B N   1 
ATOM   2265 C CA  . LYS B 2 6   ? -35.44168 -32.16120 8.18058   1.000 18.03943 ? 6   LYS B CA  1 
ATOM   2266 C C   . LYS B 2 6   ? -34.89069 -31.40257 6.99223   1.000 18.23668 ? 6   LYS B C   1 
ATOM   2267 O O   . LYS B 2 6   ? -33.67482 -31.36547 6.77966   1.000 20.19864 ? 6   LYS B O   1 
ATOM   2268 C CB  . LYS B 2 6   ? -35.47466 -31.28187 9.42987   1.000 23.06456 ? 6   LYS B CB  1 
ATOM   2269 C CG  . LYS B 2 6   ? -35.48941 -32.06002 10.72919  1.000 26.63891 ? 6   LYS B CG  1 
ATOM   2270 C CD  . LYS B 2 6   ? -34.81720 -31.26996 11.83888  1.000 31.84872 ? 6   LYS B CD  1 
ATOM   2271 C CE  . LYS B 2 6   ? -35.33938 -31.67740 13.22438  1.000 34.60236 ? 6   LYS B CE  1 
ATOM   2272 N NZ  . LYS B 2 6   ? -35.24979 -33.16081 13.44562  1.000 41.34973 ? 6   LYS B NZ  1 
ATOM   2273 N N   . ILE B 2 7   ? -35.78876 -30.84041 6.18596   1.000 15.58399 ? 7   ILE B N   1 
ATOM   2274 C CA  . ILE B 2 7   ? -35.44520 -30.33802 4.86030   1.000 14.96489 ? 7   ILE B CA  1 
ATOM   2275 C C   . ILE B 2 7   ? -35.99155 -28.92266 4.73385   1.000 18.10323 ? 7   ILE B C   1 
ATOM   2276 O O   . ILE B 2 7   ? -37.17320 -28.67138 5.01058   1.000 17.72730 ? 7   ILE B O   1 
ATOM   2277 C CB  . ILE B 2 7   ? -36.01698 -31.24453 3.75159   1.000 13.44396 ? 7   ILE B CB  1 
ATOM   2278 C CG1 . ILE B 2 7   ? -35.40319 -32.64487 3.86269   1.000 17.28774 ? 7   ILE B CG1 1 
ATOM   2279 C CG2 . ILE B 2 7   ? -35.73324 -30.65925 2.36740   1.000 15.86913 ? 7   ILE B CG2 1 
ATOM   2280 C CD1 . ILE B 2 7   ? -36.19969 -33.74223 3.17641   1.000 22.64987 ? 7   ILE B CD1 1 
ATOM   2281 N N   . GLN B 2 8   ? -35.13326 -27.99951 4.34597   1.000 15.75061 ? 8   GLN B N   1 
ATOM   2282 C CA  . GLN B 2 8   ? -35.49676 -26.60453 4.16695   1.000 12.79070 ? 8   GLN B CA  1 
ATOM   2283 C C   . GLN B 2 8   ? -34.96348 -26.14540 2.81583   1.000 15.96869 ? 8   GLN B C   1 
ATOM   2284 O O   . GLN B 2 8   ? -33.77246 -26.30518 2.53032   1.000 17.89891 ? 8   GLN B O   1 
ATOM   2285 C CB  . GLN B 2 8   ? -34.92409 -25.74547 5.29804   1.000 14.86535 ? 8   GLN B CB  1 
ATOM   2286 C CG  . GLN B 2 8   ? -35.55790 -25.98058 6.65429   1.000 18.18334 ? 8   GLN B CG  1 
ATOM   2287 C CD  . GLN B 2 8   ? -35.32062 -24.82176 7.63014   1.000 15.84981 ? 8   GLN B CD  1 
ATOM   2288 O OE1 . GLN B 2 8   ? -35.86115 -23.72148 7.46989   1.000 17.42331 ? 8   GLN B OE1 1 
ATOM   2289 N NE2 . GLN B 2 8   ? -34.50947 -25.07663 8.65027   1.000 16.52811 ? 8   GLN B NE2 1 
ATOM   2290 N N   . VAL B 2 9   ? -35.82190 -25.55414 1.99713   1.000 15.01445 ? 9   VAL B N   1 
ATOM   2291 C CA  . VAL B 2 9   ? -35.42804 -25.04807 0.68592   1.000 14.57570 ? 9   VAL B CA  1 
ATOM   2292 C C   . VAL B 2 9   ? -35.71844 -23.56566 0.66099   1.000 18.45376 ? 9   VAL B C   1 
ATOM   2293 O O   . VAL B 2 9   ? -36.85652 -23.14452 0.92257   1.000 17.32989 ? 9   VAL B O   1 
ATOM   2294 C CB  . VAL B 2 9   ? -36.16113 -25.76605 -0.44873  1.000 17.51950 ? 9   VAL B CB  1 
ATOM   2295 C CG1 . VAL B 2 9   ? -35.43499 -25.50229 -1.78231  1.000 19.24089 ? 9   VAL B CG1 1 
ATOM   2296 C CG2 . VAL B 2 9   ? -36.25447 -27.24474 -0.14140  1.000 19.72743 ? 9   VAL B CG2 1 
ATOM   2297 N N   . TYR B 2 10  ? -34.70368 -22.76841 0.36049   1.000 16.02614 ? 10  TYR B N   1 
ATOM   2298 C CA  . TYR B 2 10  ? -34.85168 -21.33013 0.51566   1.000 16.67346 ? 10  TYR B CA  1 
ATOM   2299 C C   . TYR B 2 10  ? -33.78867 -20.63483 -0.31337  1.000 19.84609 ? 10  TYR B C   1 
ATOM   2300 O O   . TYR B 2 10  ? -32.82728 -21.25414 -0.76700  1.000 20.18323 ? 10  TYR B O   1 
ATOM   2301 C CB  . TYR B 2 10  ? -34.74434 -20.91811 1.98224   1.000 17.32449 ? 10  TYR B CB  1 
ATOM   2302 C CG  . TYR B 2 10  ? -33.48081 -21.41573 2.64605   1.000 18.26783 ? 10  TYR B CG  1 
ATOM   2303 C CD1 . TYR B 2 10  ? -33.39726 -22.71427 3.13484   1.000 15.16293 ? 10  TYR B CD1 1 
ATOM   2304 C CD2 . TYR B 2 10  ? -32.38112 -20.57977 2.80313   1.000 18.53906 ? 10  TYR B CD2 1 
ATOM   2305 C CE1 . TYR B 2 10  ? -32.25158 -23.16955 3.74532   1.000 16.34126 ? 10  TYR B CE1 1 
ATOM   2306 C CE2 . TYR B 2 10  ? -31.21457 -21.03026 3.40507   1.000 17.00988 ? 10  TYR B CE2 1 
ATOM   2307 C CZ  . TYR B 2 10  ? -31.16012 -22.32390 3.87061   1.000 16.59206 ? 10  TYR B CZ  1 
ATOM   2308 O OH  . TYR B 2 10  ? -30.03362 -22.78643 4.47222   1.000 16.43876 ? 10  TYR B OH  1 
ATOM   2309 N N   . SER B 2 11  ? -33.97492 -19.33455 -0.50929  1.000 21.78047 ? 11  SER B N   1 
ATOM   2310 C CA  . SER B 2 11  ? -32.98707 -18.53368 -1.20935  1.000 22.23690 ? 11  SER B CA  1 
ATOM   2311 C C   . SER B 2 11  ? -32.12889 -17.78436 -0.19722  1.000 23.58918 ? 11  SER B C   1 
ATOM   2312 O O   . SER B 2 11  ? -32.51660 -17.57493 0.95535   1.000 23.36431 ? 11  SER B O   1 
ATOM   2313 C CB  . SER B 2 11  ? -33.65596 -17.56072 -2.18645  1.000 28.14930 ? 11  SER B CB  1 
ATOM   2314 O OG  . SER B 2 11  ? -34.59615 -16.73306 -1.52939  1.000 24.10096 ? 11  SER B OG  1 
ATOM   2315 N N   . ARG B 2 12  ? -30.92633 -17.41798 -0.62596  1.000 22.08088 ? 12  ARG B N   1 
ATOM   2316 C CA  . ARG B 2 12  ? -30.03309 -16.76630 0.31102   1.000 23.21667 ? 12  ARG B CA  1 
ATOM   2317 C C   . ARG B 2 12  ? -30.55572 -15.37947 0.66166   1.000 25.76369 ? 12  ARG B C   1 
ATOM   2318 O O   . ARG B 2 12  ? -30.55416 -14.98615 1.83614   1.000 22.41014 ? 12  ARG B O   1 
ATOM   2319 C CB  . ARG B 2 12  ? -28.62416 -16.70020 -0.25519  1.000 23.56926 ? 12  ARG B CB  1 
ATOM   2320 C CG  . ARG B 2 12  ? -27.74259 -15.81493 0.55211   1.000 20.99290 ? 12  ARG B CG  1 
ATOM   2321 C CD  . ARG B 2 12  ? -26.39923 -15.67057 -0.08160  1.000 22.19915 ? 12  ARG B CD  1 
ATOM   2322 N NE  . ARG B 2 12  ? -25.72466 -16.96143 -0.17426  1.000 21.78151 ? 12  ARG B NE  1 
ATOM   2323 C CZ  . ARG B 2 12  ? -24.53720 -17.13360 -0.74069  1.000 23.77969 ? 12  ARG B CZ  1 
ATOM   2324 N NH1 . ARG B 2 12  ? -23.85422 -16.11034 -1.22481  1.000 22.76826 ? 12  ARG B NH1 1 
ATOM   2325 N NH2 . ARG B 2 12  ? -24.01531 -18.35862 -0.80254  1.000 22.26207 ? 12  ARG B NH2 1 
ATOM   2326 N N   . HIS B 2 13  ? -31.05397 -14.65205 -0.33560  1.000 22.77368 ? 13  HIS B N   1 
ATOM   2327 C CA  . HIS B 2 13  ? -31.72884 -13.37380 -0.16723  1.000 24.09455 ? 13  HIS B CA  1 
ATOM   2328 C C   . HIS B 2 13  ? -33.19613 -13.51212 -0.53926  1.000 27.71854 ? 13  HIS B C   1 
ATOM   2329 O O   . HIS B 2 13  ? -33.56335 -14.42196 -1.28936  1.000 24.07194 ? 13  HIS B O   1 
ATOM   2330 C CB  . HIS B 2 13  ? -31.07913 -12.31326 -1.05811  1.000 26.92542 ? 13  HIS B CB  1 
ATOM   2331 C CG  . HIS B 2 13  ? -29.60182 -12.21598 -0.88595  1.000 25.58558 ? 13  HIS B CG  1 
ATOM   2332 N ND1 . HIS B 2 13  ? -29.01748 -11.89932 0.32037   1.000 30.99380 ? 13  HIS B ND1 1 
ATOM   2333 C CD2 . HIS B 2 13  ? -28.58603 -12.44663 -1.74948  1.000 25.14452 ? 13  HIS B CD2 1 
ATOM   2334 C CE1 . HIS B 2 13  ? -27.70263 -11.90331 0.18360   1.000 28.86273 ? 13  HIS B CE1 1 
ATOM   2335 N NE2 . HIS B 2 13  ? -27.41473 -12.24525 -1.05874  1.000 23.08217 ? 13  HIS B NE2 1 
ATOM   2336 N N   . PRO B 2 14  ? -34.07004 -12.63647 -0.03043  1.000 26.84490 ? 14  PRO B N   1 
ATOM   2337 C CA  . PRO B 2 14  ? -35.47766 -12.66843 -0.46057  1.000 23.49440 ? 14  PRO B CA  1 
ATOM   2338 C C   . PRO B 2 14  ? -35.59066 -12.53499 -1.97618  1.000 26.86770 ? 14  PRO B C   1 
ATOM   2339 O O   . PRO B 2 14  ? -34.94793 -11.68360 -2.59280  1.000 29.83882 ? 14  PRO B O   1 
ATOM   2340 C CB  . PRO B 2 14  ? -36.09152 -11.46718 0.26322   1.000 29.16668 ? 14  PRO B CB  1 
ATOM   2341 C CG  . PRO B 2 14  ? -35.27657 -11.33898 1.51064   1.000 28.88929 ? 14  PRO B CG  1 
ATOM   2342 C CD  . PRO B 2 14  ? -33.85735 -11.69230 1.08026   1.000 29.16751 ? 14  PRO B CD  1 
ATOM   2343 N N   . ALA B 2 15  ? -36.41967 -13.38707 -2.57713  1.000 29.19400 ? 15  ALA B N   1 
ATOM   2344 C CA  . ALA B 2 15  ? -36.37906 -13.57331 -4.02311  1.000 27.42873 ? 15  ALA B CA  1 
ATOM   2345 C C   . ALA B 2 15  ? -36.90840 -12.35508 -4.76587  1.000 33.67313 ? 15  ALA B C   1 
ATOM   2346 O O   . ALA B 2 15  ? -37.93667 -11.77094 -4.40112  1.000 31.71638 ? 15  ALA B O   1 
ATOM   2347 C CB  . ALA B 2 15  ? -37.19128 -14.79909 -4.43389  1.000 25.32494 ? 15  ALA B CB  1 
ATOM   2348 N N   . GLU B 2 16  ? -36.21405 -12.00085 -5.84012  1.000 29.47856 ? 16  GLU B N   1 
ATOM   2349 C CA  . GLU B 2 16  ? -36.65661 -10.95001 -6.74671  1.000 32.72349 ? 16  GLU B CA  1 
ATOM   2350 C C   . GLU B 2 16  ? -36.36537 -11.41244 -8.16322  1.000 34.64837 ? 16  GLU B C   1 
ATOM   2351 O O   . GLU B 2 16  ? -35.19875 -11.59775 -8.52689  1.000 28.35022 ? 16  GLU B O   1 
ATOM   2352 C CB  . GLU B 2 16  ? -35.94816 -9.62724  -6.44321  1.000 40.49369 ? 16  GLU B CB  1 
ATOM   2353 C CG  . GLU B 2 16  ? -36.60306 -8.41104  -7.07347  1.000 52.35524 ? 16  GLU B CG  1 
ATOM   2354 C CD  . GLU B 2 16  ? -36.36052 -7.14153  -6.27132  1.000 61.88416 ? 16  GLU B CD  1 
ATOM   2355 O OE1 . GLU B 2 16  ? -35.42983 -7.13590  -5.42994  1.000 56.53175 ? 16  GLU B OE1 1 
ATOM   2356 O OE2 . GLU B 2 16  ? -37.11124 -6.15833  -6.47803  1.000 68.20072 ? 16  GLU B OE2 1 
ATOM   2357 N N   . ASN B 2 17  ? -37.42511 -11.61149 -8.94559  1.000 30.45939 ? 17  ASN B N   1 
ATOM   2358 C CA  . ASN B 2 17  ? -37.28885 -12.07851 -10.31701 1.000 29.53859 ? 17  ASN B CA  1 
ATOM   2359 C C   . ASN B 2 17  ? -36.30862 -11.21245 -11.08946 1.000 31.13260 ? 17  ASN B C   1 
ATOM   2360 O O   . ASN B 2 17  ? -36.35881 -9.98264  -11.01869 1.000 34.44209 ? 17  ASN B O   1 
ATOM   2361 C CB  . ASN B 2 17  ? -38.65746 -12.07084 -10.99492 1.000 27.61805 ? 17  ASN B CB  1 
ATOM   2362 C CG  . ASN B 2 17  ? -39.56355 -13.14012 -10.45497 1.000 33.50265 ? 17  ASN B CG  1 
ATOM   2363 O OD1 . ASN B 2 17  ? -39.09400 -14.16802 -9.95700  1.000 34.16170 ? 17  ASN B OD1 1 
ATOM   2364 N ND2 . ASN B 2 17  ? -40.86878 -12.90184 -10.51533 1.000 35.60133 ? 17  ASN B ND2 1 
ATOM   2365 N N   . GLY B 2 18  ? -35.39355 -11.86520 -11.80277 1.000 31.63232 ? 18  GLY B N   1 
ATOM   2366 C CA  . GLY B 2 18  ? -34.39973 -11.17600 -12.59836 1.000 30.95566 ? 18  GLY B CA  1 
ATOM   2367 C C   . GLY B 2 18  ? -33.13584 -10.79131 -11.86371 1.000 32.56987 ? 18  GLY B C   1 
ATOM   2368 O O   . GLY B 2 18  ? -32.20890 -10.26937 -12.49218 1.000 28.75846 ? 18  GLY B O   1 
ATOM   2369 N N   . LYS B 2 19  ? -33.06291 -11.01456 -10.55554 1.000 31.89642 ? 19  LYS B N   1 
ATOM   2370 C CA  . LYS B 2 19  ? -31.88085 -10.66892 -9.78189  1.000 32.57011 ? 19  LYS B CA  1 
ATOM   2371 C C   . LYS B 2 19  ? -31.20500 -11.94050 -9.29100  1.000 32.26330 ? 19  LYS B C   1 
ATOM   2372 O O   . LYS B 2 19  ? -31.85021 -12.79909 -8.68245  1.000 33.79030 ? 19  LYS B O   1 
ATOM   2373 C CB  . LYS B 2 19  ? -32.23709 -9.74537  -8.61073  1.000 33.12725 ? 19  LYS B CB  1 
ATOM   2374 C CG  . LYS B 2 19  ? -33.07364 -8.53523  -9.03787  1.000 38.41791 ? 19  LYS B CG  1 
ATOM   2375 C CD  . LYS B 2 19  ? -32.17266 -7.43577  -9.62627  1.000 44.43675 ? 19  LYS B CD  1 
ATOM   2376 C CE  . LYS B 2 19  ? -32.73357 -6.02284  -9.45094  1.000 42.57568 ? 19  LYS B CE  1 
ATOM   2377 N NZ  . LYS B 2 19  ? -32.85490 -5.63964  -8.01749  1.000 38.76361 ? 19  LYS B NZ  1 
ATOM   2378 N N   . SER B 2 20  ? -29.91138 -12.05242 -9.56112  1.000 29.74331 ? 20  SER B N   1 
ATOM   2379 C CA  . SER B 2 20  ? -29.14833 -13.22994 -9.17697  1.000 29.83621 ? 20  SER B CA  1 
ATOM   2380 C C   . SER B 2 20  ? -29.19707 -13.46778 -7.66724  1.000 28.27300 ? 20  SER B C   1 
ATOM   2381 O O   . SER B 2 20  ? -29.28269 -12.53641 -6.86311  1.000 28.73196 ? 20  SER B O   1 
ATOM   2382 C CB  . SER B 2 20  ? -27.70660 -13.07311 -9.64424  1.000 26.33256 ? 20  SER B CB  1 
ATOM   2383 O OG  . SER B 2 20  ? -27.00072 -12.25159 -8.73731  1.000 37.13013 ? 20  SER B OG  1 
ATOM   2384 N N   . ASN B 2 21  ? -29.11323 -14.74102 -7.28857  1.000 29.62845 ? 21  ASN B N   1 
ATOM   2385 C CA  . ASN B 2 21  ? -29.40291 -15.20305 -5.93648  1.000 25.11826 ? 21  ASN B CA  1 
ATOM   2386 C C   . ASN B 2 21  ? -28.73467 -16.56979 -5.78822  1.000 25.51285 ? 21  ASN B C   1 
ATOM   2387 O O   . ASN B 2 21  ? -28.00976 -17.02840 -6.67677  1.000 23.94560 ? 21  ASN B O   1 
ATOM   2388 C CB  . ASN B 2 21  ? -30.92612 -15.25266 -5.71804  1.000 22.96653 ? 21  ASN B CB  1 
ATOM   2389 C CG  . ASN B 2 21  ? -31.35826 -15.01262 -4.26340  1.000 25.63372 ? 21  ASN B CG  1 
ATOM   2390 O OD1 . ASN B 2 21  ? -30.64779 -15.35150 -3.32295  1.000 22.23632 ? 21  ASN B OD1 1 
ATOM   2391 N ND2 . ASN B 2 21  ? -32.57204 -14.47451 -4.08693  1.000 23.14674 ? 21  ASN B ND2 1 
ATOM   2392 N N   . PHE B 2 22  ? -28.95431 -17.20476 -4.65019  1.000 20.46399 ? 22  PHE B N   1 
ATOM   2393 C CA  . PHE B 2 22  ? -28.54320 -18.58343 -4.42826  1.000 19.11926 ? 22  PHE B CA  1 
ATOM   2394 C C   . PHE B 2 22  ? -29.74052 -19.37254 -3.94459  1.000 20.41248 ? 22  PHE B C   1 
ATOM   2395 O O   . PHE B 2 22  ? -30.52588 -18.87058 -3.13228  1.000 20.34983 ? 22  PHE B O   1 
ATOM   2396 C CB  . PHE B 2 22  ? -27.43780 -18.71341 -3.39716  1.000 17.89899 ? 22  PHE B CB  1 
ATOM   2397 C CG  . PHE B 2 22  ? -26.09771 -18.34271 -3.92063  1.000 20.12372 ? 22  PHE B CG  1 
ATOM   2398 C CD1 . PHE B 2 22  ? -25.75055 -17.01503 -4.06428  1.000 26.10433 ? 22  PHE B CD1 1 
ATOM   2399 C CD2 . PHE B 2 22  ? -25.19123 -19.31934 -4.30121  1.000 23.35276 ? 22  PHE B CD2 1 
ATOM   2400 C CE1 . PHE B 2 22  ? -24.51408 -16.67370 -4.56557  1.000 25.52357 ? 22  PHE B CE1 1 
ATOM   2401 C CE2 . PHE B 2 22  ? -23.95823 -18.97304 -4.81078  1.000 23.90204 ? 22  PHE B CE2 1 
ATOM   2402 C CZ  . PHE B 2 22  ? -23.62790 -17.65631 -4.93424  1.000 21.04976 ? 22  PHE B CZ  1 
ATOM   2403 N N   . LEU B 2 23  ? -29.85592 -20.60759 -4.43278  1.000 15.90783 ? 23  LEU B N   1 
ATOM   2404 C CA  . LEU B 2 23  ? -30.89697 -21.54073 -4.01821  1.000 19.44069 ? 23  LEU B CA  1 
ATOM   2405 C C   . LEU B 2 23  ? -30.26431 -22.58379 -3.10766  1.000 19.27301 ? 23  LEU B C   1 
ATOM   2406 O O   . LEU B 2 23  ? -29.29289 -23.24774 -3.49894  1.000 19.64591 ? 23  LEU B O   1 
ATOM   2407 C CB  . LEU B 2 23  ? -31.57400 -22.19464 -5.22791  1.000 20.14667 ? 23  LEU B CB  1 
ATOM   2408 C CG  . LEU B 2 23  ? -32.56643 -23.29069 -4.83047  1.000 19.58956 ? 23  LEU B CG  1 
ATOM   2409 C CD1 . LEU B 2 23  ? -33.76373 -22.70277 -4.10866  1.000 14.56422 ? 23  LEU B CD1 1 
ATOM   2410 C CD2 . LEU B 2 23  ? -32.98403 -24.05124 -6.08170  1.000 23.17307 ? 23  LEU B CD2 1 
ATOM   2411 N N   . ASN B 2 24  ? -30.78836 -22.69347 -1.88773  1.000 14.79816 ? 24  ASN B N   1 
ATOM   2412 C CA  . ASN B 2 24  ? -30.25017 -23.57182 -0.86094  1.000 11.54867 ? 24  ASN B CA  1 
ATOM   2413 C C   . ASN B 2 24  ? -31.20788 -24.71224 -0.55320  1.000 18.99324 ? 24  ASN B C   1 
ATOM   2414 O O   . ASN B 2 24  ? -32.43396 -24.54073 -0.54200  1.000 15.65311 ? 24  ASN B O   1 
ATOM   2415 C CB  . ASN B 2 24  ? -29.95537 -22.83941 0.45372   1.000 16.92285 ? 24  ASN B CB  1 
ATOM   2416 C CG  . ASN B 2 24  ? -28.96267 -21.69804 0.29895   1.000 18.86983 ? 24  ASN B CG  1 
ATOM   2417 O OD1 . ASN B 2 24  ? -27.80709 -21.91977 -0.04422  1.000 20.73450 ? 24  ASN B OD1 1 
ATOM   2418 N ND2 . ASN B 2 24  ? -29.36858 -20.50722 0.68543   1.000 17.20453 ? 24  ASN B ND2 1 
ATOM   2419 N N   . CYS B 2 25  ? -30.62462 -25.87256 -0.28371  1.000 14.46089 ? 25  CYS B N   1 
ATOM   2420 C CA  . CYS B 2 25  ? -31.33637 -26.99379 0.29578   1.000 16.53443 ? 25  CYS B CA  1 
ATOM   2421 C C   . CYS B 2 25  ? -30.53282 -27.43832 1.49993   1.000 18.61340 ? 25  CYS B C   1 
ATOM   2422 O O   . CYS B 2 25  ? -29.39497 -27.91308 1.36659   1.000 17.14327 ? 25  CYS B O   1 
ATOM   2423 C CB  . CYS B 2 25  ? -31.51832 -28.13436 -0.68578  1.000 19.17400 ? 25  CYS B CB  1 
ATOM   2424 S SG  . CYS B 2 25  ? -32.59784 -29.37986 0.02294   1.000 22.84440 ? 25  CYS B SG  1 
ATOM   2425 N N   . TYR B 2 26  ? -31.11488 -27.26459 2.66868   1.000 13.15478 ? 26  TYR B N   1 
ATOM   2426 C CA  . TYR B 2 26  ? -30.43572 -27.54221 3.91959   1.000 12.76331 ? 26  TYR B CA  1 
ATOM   2427 C C   . TYR B 2 26  ? -31.06206 -28.78566 4.52228   1.000 14.66636 ? 26  TYR B C   1 
ATOM   2428 O O   . TYR B 2 26  ? -32.27292 -28.80951 4.78836   1.000 16.07289 ? 26  TYR B O   1 
ATOM   2429 C CB  . TYR B 2 26  ? -30.55912 -26.33155 4.84324   1.000 14.99374 ? 26  TYR B CB  1 
ATOM   2430 C CG  . TYR B 2 26  ? -29.89692 -26.49489 6.18354   1.000 15.57237 ? 26  TYR B CG  1 
ATOM   2431 C CD1 . TYR B 2 26  ? -28.53609 -26.74821 6.26962   1.000 15.12470 ? 26  TYR B CD1 1 
ATOM   2432 C CD2 . TYR B 2 26  ? -30.61734 -26.36508 7.36547   1.000 14.28131 ? 26  TYR B CD2 1 
ATOM   2433 C CE1 . TYR B 2 26  ? -27.92007 -26.90166 7.48363   1.000 13.92196 ? 26  TYR B CE1 1 
ATOM   2434 C CE2 . TYR B 2 26  ? -29.99127 -26.50834 8.61058   1.000 18.04615 ? 26  TYR B CE2 1 
ATOM   2435 C CZ  . TYR B 2 26  ? -28.63641 -26.77435 8.64962   1.000 19.70004 ? 26  TYR B CZ  1 
ATOM   2436 O OH  . TYR B 2 26  ? -27.97734 -26.92321 9.85731   1.000 23.05236 ? 26  TYR B OH  1 
ATOM   2437 N N   . VAL B 2 27  ? -30.25532 -29.82527 4.71571   1.000 15.10785 ? 27  VAL B N   1 
ATOM   2438 C CA  . VAL B 2 27  ? -30.70442 -31.06591 5.32822   1.000 15.68859 ? 27  VAL B CA  1 
ATOM   2439 C C   . VAL B 2 27  ? -30.01305 -31.18071 6.67483   1.000 16.51619 ? 27  VAL B C   1 
ATOM   2440 O O   . VAL B 2 27  ? -28.78773 -31.03483 6.76282   1.000 15.19218 ? 27  VAL B O   1 
ATOM   2441 C CB  . VAL B 2 27  ? -30.41340 -32.28438 4.42940   1.000 17.72207 ? 27  VAL B CB  1 
ATOM   2442 C CG1 . VAL B 2 27  ? -31.37880 -32.30732 3.26288   1.000 17.75136 ? 27  VAL B CG1 1 
ATOM   2443 C CG2 . VAL B 2 27  ? -28.96883 -32.26654 3.89825   1.000 17.53588 ? 27  VAL B CG2 1 
ATOM   2444 N N   . SER B 2 28  ? -30.79312 -31.39976 7.73061   1.000 16.58464 ? 28  SER B N   1 
ATOM   2445 C CA  . SER B 2 28  ? -30.20377 -31.50667 9.05566   1.000 14.47202 ? 28  SER B CA  1 
ATOM   2446 C C   . SER B 2 28  ? -30.90988 -32.58986 9.85203   1.000 19.31607 ? 28  SER B C   1 
ATOM   2447 O O   . SER B 2 28  ? -32.00955 -33.03687 9.51093   1.000 20.01981 ? 28  SER B O   1 
ATOM   2448 C CB  . SER B 2 28  ? -30.29269 -30.18676 9.82642   1.000 18.18755 ? 28  SER B CB  1 
ATOM   2449 O OG  . SER B 2 28  ? -31.65363 -29.77069 9.93378   1.000 20.15389 ? 28  SER B OG  1 
ATOM   2450 N N   . GLY B 2 29  ? -30.25313 -33.00923 10.92604  1.000 17.50077 ? 29  GLY B N   1 
ATOM   2451 C CA  . GLY B 2 29  ? -30.89585 -33.89540 11.87915  1.000 18.59408 ? 29  GLY B CA  1 
ATOM   2452 C C   . GLY B 2 29  ? -31.04751 -35.32512 11.42814  1.000 20.47035 ? 29  GLY B C   1 
ATOM   2453 O O   . GLY B 2 29  ? -31.90290 -36.03778 11.96911  1.000 19.32393 ? 29  GLY B O   1 
ATOM   2454 N N   . PHE B 2 30  ? -30.24966 -35.77550 10.45375  1.000 17.11595 ? 30  PHE B N   1 
ATOM   2455 C CA  . PHE B 2 30  ? -30.37300 -37.12806 9.92636   1.000 13.93007 ? 30  PHE B CA  1 
ATOM   2456 C C   . PHE B 2 30  ? -29.22262 -38.04087 10.36375  1.000 21.82974 ? 30  PHE B C   1 
ATOM   2457 O O   . PHE B 2 30  ? -28.16667 -37.60052 10.82773  1.000 15.03837 ? 30  PHE B O   1 
ATOM   2458 C CB  . PHE B 2 30  ? -30.48473 -37.12074 8.39135   1.000 17.11159 ? 30  PHE B CB  1 
ATOM   2459 C CG  . PHE B 2 30  ? -29.31574 -36.48546 7.66528   1.000 19.03769 ? 30  PHE B CG  1 
ATOM   2460 C CD1 . PHE B 2 30  ? -29.29184 -35.12447 7.39920   1.000 13.99018 ? 30  PHE B CD1 1 
ATOM   2461 C CD2 . PHE B 2 30  ? -28.28894 -37.26500 7.18707   1.000 14.85990 ? 30  PHE B CD2 1 
ATOM   2462 C CE1 . PHE B 2 30  ? -28.23313 -34.55346 6.71758   1.000 19.45489 ? 30  PHE B CE1 1 
ATOM   2463 C CE2 . PHE B 2 30  ? -27.23375 -36.70298 6.51606   1.000 17.86031 ? 30  PHE B CE2 1 
ATOM   2464 C CZ  . PHE B 2 30  ? -27.21194 -35.33618 6.26977   1.000 17.59330 ? 30  PHE B CZ  1 
ATOM   2465 N N   . HIS B 2 31  ? -29.46175 -39.34915 10.22083  1.000 18.43341 ? 31  HIS B N   1 
ATOM   2466 C CA  . HIS B 2 31  ? -28.49070 -40.39809 10.46919  1.000 17.78099 ? 31  HIS B CA  1 
ATOM   2467 C C   . HIS B 2 31  ? -29.04807 -41.63433 9.78930   1.000 17.82719 ? 31  HIS B C   1 
ATOM   2468 O O   . HIS B 2 31  ? -30.25860 -41.87762 9.89268   1.000 23.78679 ? 31  HIS B O   1 
ATOM   2469 C CB  . HIS B 2 31  ? -28.27964 -40.65431 11.96806  1.000 23.22070 ? 31  HIS B CB  1 
ATOM   2470 C CG  . HIS B 2 31  ? -26.85781 -40.94779 12.33379  1.000 25.35152 ? 31  HIS B CG  1 
ATOM   2471 N ND1 . HIS B 2 31  ? -26.28637 -42.19317 12.17780  1.000 21.27814 ? 31  HIS B ND1 1 
ATOM   2472 C CD2 . HIS B 2 31  ? -25.89053 -40.15109 12.85567  1.000 23.87498 ? 31  HIS B CD2 1 
ATOM   2473 C CE1 . HIS B 2 31  ? -25.02217 -42.14621 12.55890  1.000 20.84540 ? 31  HIS B CE1 1 
ATOM   2474 N NE2 . HIS B 2 31  ? -24.75797 -40.92264 12.98508  1.000 22.56013 ? 31  HIS B NE2 1 
ATOM   2475 N N   . PRO B 2 32  ? -28.23224 -42.41898 9.08171   1.000 19.44296 ? 32  PRO B N   1 
ATOM   2476 C CA  . PRO B 2 32  ? -26.78831 -42.23707 8.87018   1.000 22.68103 ? 32  PRO B CA  1 
ATOM   2477 C C   . PRO B 2 32  ? -26.45147 -41.14455 7.85788   1.000 18.99059 ? 32  PRO B C   1 
ATOM   2478 O O   . PRO B 2 32  ? -27.32092 -40.48071 7.32175   1.000 20.76711 ? 32  PRO B O   1 
ATOM   2479 C CB  . PRO B 2 32  ? -26.32363 -43.60996 8.36519   1.000 22.60806 ? 32  PRO B CB  1 
ATOM   2480 C CG  . PRO B 2 32  ? -27.55218 -44.36565 7.94671   1.000 25.39130 ? 32  PRO B CG  1 
ATOM   2481 C CD  . PRO B 2 32  ? -28.77044 -43.56649 8.32997   1.000 21.05781 ? 32  PRO B CD  1 
ATOM   2482 N N   . SER B 2 33  ? -25.16252 -40.94153 7.56949   1.000 17.16092 ? 33  SER B N   1 
ATOM   2483 C CA  . SER B 2 33  ? -24.75488 -39.78134 6.79097   1.000 19.14056 ? 33  SER B CA  1 
ATOM   2484 C C   . SER B 2 33  ? -24.91019 -39.97966 5.28458   1.000 20.07155 ? 33  SER B C   1 
ATOM   2485 O O   . SER B 2 33  ? -24.99635 -38.98688 4.55599   1.000 20.81333 ? 33  SER B O   1 
ATOM   2486 C CB  . SER B 2 33  ? -23.30358 -39.41722 7.11619   1.000 20.18595 ? 33  SER B CB  1 
ATOM   2487 O OG  . SER B 2 33  ? -22.45341 -40.44262 6.68103   1.000 17.62707 ? 33  SER B OG  1 
ATOM   2488 N N   . ASP B 2 34  ? -24.94316 -41.22315 4.80021   1.000 25.85180 ? 34  ASP B N   1 
ATOM   2489 C CA  . ASP B 2 34  ? -25.26808 -41.49073 3.39871   1.000 22.93516 ? 34  ASP B CA  1 
ATOM   2490 C C   . ASP B 2 34  ? -26.57600 -40.82751 2.98401   1.000 22.92784 ? 34  ASP B C   1 
ATOM   2491 O O   . ASP B 2 34  ? -27.64497 -41.20118 3.47885   1.000 19.37571 ? 34  ASP B O   1 
ATOM   2492 C CB  . ASP B 2 34  ? -25.37203 -42.99683 3.15368   1.000 24.80774 ? 34  ASP B CB  1 
ATOM   2493 C CG  . ASP B 2 34  ? -25.21439 -43.36449 1.69274   1.000 39.90883 ? 34  ASP B CG  1 
ATOM   2494 O OD1 . ASP B 2 34  ? -24.76064 -42.50607 0.89972   1.000 44.95004 ? 34  ASP B OD1 1 
ATOM   2495 O OD2 . ASP B 2 34  ? -25.61049 -44.49665 1.32662   1.000 43.87948 ? 34  ASP B OD2 1 
ATOM   2496 N N   . ILE B 2 35  ? -26.50825 -39.83971 2.08998   1.000 15.74707 ? 35  ILE B N   1 
ATOM   2497 C CA  . ILE B 2 35  ? -27.69688 -39.12614 1.62943   1.000 18.25933 ? 35  ILE B CA  1 
ATOM   2498 C C   . ILE B 2 35  ? -27.43421 -38.62938 0.21198   1.000 22.09148 ? 35  ILE B C   1 
ATOM   2499 O O   . ILE B 2 35  ? -26.28522 -38.38883 -0.17573  1.000 17.54512 ? 35  ILE B O   1 
ATOM   2500 C CB  . ILE B 2 35  ? -28.05118 -37.96094 2.59004   1.000 18.53362 ? 35  ILE B CB  1 
ATOM   2501 C CG1 . ILE B 2 35  ? -29.48594 -37.45648 2.36049   1.000 15.94293 ? 35  ILE B CG1 1 
ATOM   2502 C CG2 . ILE B 2 35  ? -26.99458 -36.82660 2.50708   1.000 15.88980 ? 35  ILE B CG2 1 
ATOM   2503 C CD1 . ILE B 2 35  ? -30.03482 -36.65317 3.56990   1.000 17.43663 ? 35  ILE B CD1 1 
ATOM   2504 N N   . GLU B 2 36  ? -28.50242 -38.49168 -0.56509  1.000 15.95256 ? 36  GLU B N   1 
ATOM   2505 C CA  . GLU B 2 36  ? -28.44483 -37.90987 -1.90172  1.000 19.21585 ? 36  GLU B CA  1 
ATOM   2506 C C   . GLU B 2 36  ? -29.34456 -36.68999 -1.90740  1.000 19.21582 ? 36  GLU B C   1 
ATOM   2507 O O   . GLU B 2 36  ? -30.52979 -36.80172 -1.57445  1.000 20.26292 ? 36  GLU B O   1 
ATOM   2508 C CB  . GLU B 2 36  ? -28.99448 -38.83608 -2.97788  1.000 20.23825 ? 36  GLU B CB  1 
ATOM   2509 C CG  . GLU B 2 36  ? -28.07155 -39.71188 -3.72733  1.000 24.83461 ? 36  GLU B CG  1 
ATOM   2510 C CD  . GLU B 2 36  ? -28.74406 -40.21418 -5.00852  1.000 33.37466 ? 36  GLU B CD  1 
ATOM   2511 O OE1 . GLU B 2 36  ? -29.47870 -41.22851 -4.93393  1.000 22.46549 ? 36  GLU B OE1 1 
ATOM   2512 O OE2 . GLU B 2 36  ? -28.48129 -39.62641 -6.10361  1.000 30.62490 ? 36  GLU B OE2 1 
ATOM   2513 N N   . VAL B 2 37  ? -28.81065 -35.53936 -2.30782  1.000 18.62182 ? 37  VAL B N   1 
ATOM   2514 C CA  . VAL B 2 37  ? -29.59831 -34.31746 -2.37311  1.000 15.41858 ? 37  VAL B CA  1 
ATOM   2515 C C   . VAL B 2 37  ? -29.43903 -33.70603 -3.75838  1.000 24.12746 ? 37  VAL B C   1 
ATOM   2516 O O   . VAL B 2 37  ? -28.31741 -33.46737 -4.21538  1.000 21.80737 ? 37  VAL B O   1 
ATOM   2517 C CB  . VAL B 2 37  ? -29.19545 -33.31073 -1.28255  1.000 20.62617 ? 37  VAL B CB  1 
ATOM   2518 C CG1 . VAL B 2 37  ? -30.10393 -32.09306 -1.32650  1.000 15.55801 ? 37  VAL B CG1 1 
ATOM   2519 C CG2 . VAL B 2 37  ? -29.26419 -33.96481 0.08393   1.000 18.49288 ? 37  VAL B CG2 1 
ATOM   2520 N N   . ASP B 2 38  ? -30.55649 -33.44257 -4.41491  1.000 18.67464 ? 38  ASP B N   1 
ATOM   2521 C CA  . ASP B 2 38  ? -30.56294 -32.86666 -5.74859  1.000 18.16063 ? 38  ASP B CA  1 
ATOM   2522 C C   . ASP B 2 38  ? -31.51074 -31.68605 -5.80444  1.000 23.45015 ? 38  ASP B C   1 
ATOM   2523 O O   . ASP B 2 38  ? -32.59957 -31.72320 -5.22999  1.000 22.27393 ? 38  ASP B O   1 
ATOM   2524 C CB  . ASP B 2 38  ? -30.96516 -33.91272 -6.76761  1.000 16.73883 ? 38  ASP B CB  1 
ATOM   2525 C CG  . ASP B 2 38  ? -29.86674 -34.93680 -6.98867  1.000 21.17597 ? 38  ASP B CG  1 
ATOM   2526 O OD1 . ASP B 2 38  ? -28.78852 -34.51464 -7.44102  1.000 28.01706 ? 38  ASP B OD1 1 
ATOM   2527 O OD2 . ASP B 2 38  ? -30.05212 -36.13462 -6.67440  1.000 26.56692 ? 38  ASP B OD2 1 
ATOM   2528 N N   . LEU B 2 39  ? -31.08892 -30.64629 -6.50605  1.000 19.09895 ? 39  LEU B N   1 
ATOM   2529 C CA  . LEU B 2 39  ? -31.94856 -29.52562 -6.82205  1.000 22.13359 ? 39  LEU B CA  1 
ATOM   2530 C C   . LEU B 2 39  ? -32.58204 -29.74254 -8.19220  1.000 25.55768 ? 39  LEU B C   1 
ATOM   2531 O O   . LEU B 2 39  ? -31.92817 -30.22204 -9.12672  1.000 22.33330 ? 39  LEU B O   1 
ATOM   2532 C CB  . LEU B 2 39  ? -31.14897 -28.22605 -6.80852  1.000 20.34956 ? 39  LEU B CB  1 
ATOM   2533 C CG  . LEU B 2 39  ? -30.65441 -27.79466 -5.43428  1.000 20.75780 ? 39  LEU B CG  1 
ATOM   2534 C CD1 . LEU B 2 39  ? -29.69698 -26.60698 -5.56799  1.000 21.71254 ? 39  LEU B CD1 1 
ATOM   2535 C CD2 . LEU B 2 39  ? -31.81768 -27.47702 -4.50931  1.000 25.53475 ? 39  LEU B CD2 1 
ATOM   2536 N N   . LEU B 2 40  ? -33.85786 -29.37843 -8.30518  1.000 23.92555 ? 40  LEU B N   1 
ATOM   2537 C CA  . LEU B 2 40  ? -34.64715 -29.56438 -9.51768  1.000 22.27584 ? 40  LEU B CA  1 
ATOM   2538 C C   . LEU B 2 40  ? -35.12487 -28.21005 -10.02446 1.000 24.03509 ? 40  LEU B C   1 
ATOM   2539 O O   . LEU B 2 40  ? -35.63202 -27.40250 -9.23925  1.000 22.98852 ? 40  LEU B O   1 
ATOM   2540 C CB  . LEU B 2 40  ? -35.85716 -30.46102 -9.23281  1.000 24.06994 ? 40  LEU B CB  1 
ATOM   2541 C CG  . LEU B 2 40  ? -35.60406 -31.76048 -8.46153  1.000 22.44285 ? 40  LEU B CG  1 
ATOM   2542 C CD1 . LEU B 2 40  ? -36.82797 -32.65791 -8.48149  1.000 22.90839 ? 40  LEU B CD1 1 
ATOM   2543 C CD2 . LEU B 2 40  ? -34.39872 -32.50647 -9.05706  1.000 22.29405 ? 40  LEU B CD2 1 
ATOM   2544 N N   . LYS B 2 41  ? -34.95575 -27.96492 -11.33700 1.000 20.77107 ? 41  LYS B N   1 
ATOM   2545 C CA  . LYS B 2 41  ? -35.55490 -26.83603 -12.05095 1.000 27.71312 ? 41  LYS B CA  1 
ATOM   2546 C C   . LYS B 2 41  ? -36.64389 -27.37229 -12.96810 1.000 27.71902 ? 41  LYS B C   1 
ATOM   2547 O O   . LYS B 2 41  ? -36.34544 -28.07512 -13.94590 1.000 25.21998 ? 41  LYS B O   1 
ATOM   2548 C CB  . LYS B 2 41  ? -34.54691 -26.05805 -12.89475 1.000 25.84879 ? 41  LYS B CB  1 
ATOM   2549 C CG  . LYS B 2 41  ? -35.09407 -24.69239 -13.27261 1.000 32.07528 ? 41  LYS B CG  1 
ATOM   2550 C CD  . LYS B 2 41  ? -34.04636 -23.66592 -13.66473 1.000 27.54563 ? 41  LYS B CD  1 
ATOM   2551 C CE  . LYS B 2 41  ? -33.78199 -23.66392 -15.15332 1.000 39.58598 ? 41  LYS B CE  1 
ATOM   2552 N NZ  . LYS B 2 41  ? -33.31064 -22.30182 -15.58669 1.000 32.96543 ? 41  LYS B NZ  1 
ATOM   2553 N N   . ASN B 2 42  ? -37.89585 -27.03133 -12.66179 1.000 29.37456 ? 42  ASN B N   1 
ATOM   2554 C CA  . ASN B 2 42  ? -39.04773 -27.52439 -13.41709 1.000 31.59029 ? 42  ASN B CA  1 
ATOM   2555 C C   . ASN B 2 42  ? -39.03817 -29.04989 -13.52166 1.000 34.79458 ? 42  ASN B C   1 
ATOM   2556 O O   . ASN B 2 42  ? -39.44641 -29.61733 -14.53720 1.000 34.25030 ? 42  ASN B O   1 
ATOM   2557 C CB  . ASN B 2 42  ? -39.09415 -26.89112 -14.80912 1.000 33.35399 ? 42  ASN B CB  1 
ATOM   2558 C CG  . ASN B 2 42  ? -39.14335 -25.37779 -14.75584 1.000 31.82031 ? 42  ASN B CG  1 
ATOM   2559 O OD1 . ASN B 2 42  ? -39.89754 -24.80928 -13.97446 1.000 26.23384 ? 42  ASN B OD1 1 
ATOM   2560 N ND2 . ASN B 2 42  ? -38.32644 -24.71867 -15.57359 1.000 28.08549 ? 42  ASN B ND2 1 
ATOM   2561 N N   . GLY B 2 43  ? -38.54811 -29.72237 -12.47930 1.000 30.91378 ? 43  GLY B N   1 
ATOM   2562 C CA  . GLY B 2 43  ? -38.46382 -31.16847 -12.44662 1.000 31.29492 ? 43  GLY B CA  1 
ATOM   2563 C C   . GLY B 2 43  ? -37.19617 -31.78021 -13.01368 1.000 27.14954 ? 43  GLY B C   1 
ATOM   2564 O O   . GLY B 2 43  ? -37.06491 -33.01293 -12.99751 1.000 37.44058 ? 43  GLY B O   1 
ATOM   2565 N N   . GLU B 2 44  ? -36.26700 -30.97651 -13.52578 1.000 31.99513 ? 44  GLU B N   1 
ATOM   2566 C CA  . GLU B 2 44  ? -35.02152 -31.46388 -14.10263 1.000 32.45461 ? 44  GLU B CA  1 
ATOM   2567 C C   . GLU B 2 44  ? -33.86514 -31.18820 -13.14444 1.000 29.32375 ? 44  GLU B C   1 
ATOM   2568 O O   . GLU B 2 44  ? -33.79186 -30.11966 -12.53587 1.000 24.41475 ? 44  GLU B O   1 
ATOM   2569 C CB  . GLU B 2 44  ? -34.74738 -30.80731 -15.46710 1.000 30.46083 ? 44  GLU B CB  1 
ATOM   2570 C CG  . GLU B 2 44  ? -33.49642 -31.36048 -16.18343 1.000 41.08284 ? 44  GLU B CG  1 
ATOM   2571 C CD  . GLU B 2 44  ? -32.72073 -30.31393 -17.00572 1.000 50.95254 ? 44  GLU B CD  1 
ATOM   2572 O OE1 . GLU B 2 44  ? -33.26489 -29.20846 -17.25140 1.000 47.88168 ? 44  GLU B OE1 1 
ATOM   2573 O OE2 . GLU B 2 44  ? -31.54438 -30.58812 -17.36479 1.000 44.89187 ? 44  GLU B OE2 1 
ATOM   2574 N N   . ARG B 2 45  ? -32.96410 -32.15413 -13.01358 1.000 25.50073 ? 45  ARG B N   1 
ATOM   2575 C CA  . ARG B 2 45  ? -31.85960 -32.04109 -12.06690 1.000 25.79694 ? 45  ARG B CA  1 
ATOM   2576 C C   . ARG B 2 45  ? -30.83599 -31.01270 -12.53457 1.000 28.67929 ? 45  ARG B C   1 
ATOM   2577 O O   . ARG B 2 45  ? -30.32902 -31.10499 -13.65488 1.000 28.98937 ? 45  ARG B O   1 
ATOM   2578 C CB  . ARG B 2 45  ? -31.19220 -33.40248 -11.90888 1.000 25.29904 ? 45  ARG B CB  1 
ATOM   2579 C CG  . ARG B 2 45  ? -29.90070 -33.39282 -11.11413 1.000 21.38102 ? 45  ARG B CG  1 
ATOM   2580 C CD  . ARG B 2 45  ? -29.79337 -34.68614 -10.36447 1.000 25.78597 ? 45  ARG B CD  1 
ATOM   2581 N NE  . ARG B 2 45  ? -29.64471 -35.84240 -11.23896 1.000 26.73317 ? 45  ARG B NE  1 
ATOM   2582 C CZ  . ARG B 2 45  ? -28.54019 -36.13964 -11.90654 1.000 36.58712 ? 45  ARG B CZ  1 
ATOM   2583 N NH1 . ARG B 2 45  ? -27.44275 -35.40598 -11.78464 1.000 34.26350 ? 45  ARG B NH1 1 
ATOM   2584 N NH2 . ARG B 2 45  ? -28.53154 -37.21026 -12.70273 1.000 35.97295 ? 45  ARG B NH2 1 
ATOM   2585 N N   . ILE B 2 46  ? -30.51368 -30.03973 -11.66484 1.000 24.94833 ? 46  ILE B N   1 
ATOM   2586 C CA  . ILE B 2 46  ? -29.46345 -29.05533 -11.94041 1.000 22.99556 ? 46  ILE B CA  1 
ATOM   2587 C C   . ILE B 2 46  ? -28.10095 -29.71015 -11.75194 1.000 26.03572 ? 46  ILE B C   1 
ATOM   2588 O O   . ILE B 2 46  ? -27.84541 -30.36663 -10.73131 1.000 23.15413 ? 46  ILE B O   1 
ATOM   2589 C CB  . ILE B 2 46  ? -29.61072 -27.81927 -11.02380 1.000 23.61000 ? 46  ILE B CB  1 
ATOM   2590 C CG1 . ILE B 2 46  ? -30.99112 -27.17498 -11.17243 1.000 23.81100 ? 46  ILE B CG1 1 
ATOM   2591 C CG2 . ILE B 2 46  ? -28.53611 -26.78984 -11.30978 1.000 23.32014 ? 46  ILE B CG2 1 
ATOM   2592 C CD1 . ILE B 2 46  ? -31.43889 -26.41566 -9.90916  1.000 18.78798 ? 46  ILE B CD1 1 
ATOM   2593 N N   . GLU B 2 47  ? -27.19238 -29.46635 -12.69676 1.000 25.51805 ? 47  GLU B N   1 
ATOM   2594 C CA  . GLU B 2 47  ? -25.93383 -30.20393 -12.78400 1.000 29.39101 ? 47  GLU B CA  1 
ATOM   2595 C C   . GLU B 2 47  ? -24.81612 -29.65349 -11.90558 1.000 28.75179 ? 47  GLU B C   1 
ATOM   2596 O O   . GLU B 2 47  ? -24.05520 -30.43942 -11.32914 1.000 34.59481 ? 47  GLU B O   1 
ATOM   2597 C CB  . GLU B 2 47  ? -25.45339 -30.26301 -14.24248 1.000 37.30637 ? 47  GLU B CB  1 
ATOM   2598 C CG  . GLU B 2 47  ? -26.49308 -30.83392 -15.21218 1.000 45.87904 ? 47  GLU B CG  1 
ATOM   2599 C CD  . GLU B 2 47  ? -25.88488 -31.58571 -16.40170 1.000 57.59985 ? 47  GLU B CD  1 
ATOM   2600 O OE1 . GLU B 2 47  ? -24.81728 -31.16219 -16.90821 1.000 55.61550 ? 47  GLU B OE1 1 
ATOM   2601 O OE2 . GLU B 2 47  ? -26.48851 -32.59890 -16.83325 1.000 61.17386 ? 47  GLU B OE2 1 
ATOM   2602 N N   . LYS B 2 48  ? -24.63687 -28.34011 -11.80378 1.000 27.96866 ? 48  LYS B N   1 
ATOM   2603 C CA  . LYS B 2 48  ? -23.55933 -27.82772 -10.95177 1.000 32.59990 ? 48  LYS B CA  1 
ATOM   2604 C C   . LYS B 2 48  ? -24.16862 -27.38457 -9.62349  1.000 29.48555 ? 48  LYS B C   1 
ATOM   2605 O O   . LYS B 2 48  ? -24.61232 -26.24841 -9.46197  1.000 27.41340 ? 48  LYS B O   1 
ATOM   2606 C CB  . LYS B 2 48  ? -22.75968 -26.71885 -11.63078 1.000 31.08958 ? 48  LYS B CB  1 
ATOM   2607 C CG  . LYS B 2 48  ? -21.62020 -27.26538 -12.50862 1.000 40.95794 ? 48  LYS B CG  1 
ATOM   2608 C CD  . LYS B 2 48  ? -21.13811 -26.28086 -13.57993 1.000 46.79022 ? 48  LYS B CD  1 
ATOM   2609 C CE  . LYS B 2 48  ? -21.18001 -26.86610 -14.99368 1.000 50.26526 ? 48  LYS B CE  1 
ATOM   2610 N NZ  . LYS B 2 48  ? -21.10418 -25.79189 -16.04241 1.000 53.45161 ? 48  LYS B NZ  1 
ATOM   2611 N N   . VAL B 2 49  ? -24.19783 -28.31285 -8.67033  1.000 22.44866 ? 49  VAL B N   1 
ATOM   2612 C CA  . VAL B 2 49  ? -24.69089 -28.06347 -7.32136  1.000 20.51004 ? 49  VAL B CA  1 
ATOM   2613 C C   . VAL B 2 49  ? -23.56029 -28.39254 -6.36884  1.000 21.57165 ? 49  VAL B C   1 
ATOM   2614 O O   . VAL B 2 49  ? -23.03377 -29.51258 -6.38086  1.000 26.59315 ? 49  VAL B O   1 
ATOM   2615 C CB  . VAL B 2 49  ? -25.94746 -28.88836 -6.98466  1.000 22.00241 ? 49  VAL B CB  1 
ATOM   2616 C CG1 . VAL B 2 49  ? -26.38976 -28.61338 -5.54128  1.000 19.88066 ? 49  VAL B CG1 1 
ATOM   2617 C CG2 . VAL B 2 49  ? -27.08545 -28.55900 -7.94128  1.000 22.73731 ? 49  VAL B CG2 1 
ATOM   2618 N N   . GLU B 2 50  ? -23.17139 -27.41391 -5.56938  1.000 26.73761 ? 50  GLU B N   1 
ATOM   2619 C CA  . GLU B 2 50  ? -22.13102 -27.59091 -4.57596  1.000 24.06802 ? 50  GLU B CA  1 
ATOM   2620 C C   . GLU B 2 50  ? -22.74613 -27.96572 -3.23642  1.000 23.82984 ? 50  GLU B C   1 
ATOM   2621 O O   . GLU B 2 50  ? -23.94599 -27.77944 -3.00255  1.000 20.88266 ? 50  GLU B O   1 
ATOM   2622 C CB  . GLU B 2 50  ? -21.32151 -26.30906 -4.44725  1.000 24.77155 ? 50  GLU B CB  1 
ATOM   2623 C CG  . GLU B 2 50  ? -20.23935 -26.18713 -5.51962  1.000 34.41182 ? 50  GLU B CG  1 
ATOM   2624 C CD  . GLU B 2 50  ? -19.52871 -24.86036 -5.45510  1.000 43.66536 ? 50  GLU B CD  1 
ATOM   2625 O OE1 . GLU B 2 50  ? -20.19027 -23.81838 -5.67370  1.000 47.36647 ? 50  GLU B OE1 1 
ATOM   2626 O OE2 . GLU B 2 50  ? -18.31348 -24.85839 -5.16438  1.000 51.69704 ? 50  GLU B OE2 1 
ATOM   2627 N N   . HIS B 2 51  ? -21.91752 -28.52993 -2.35950  1.000 23.78585 ? 51  HIS B N   1 
ATOM   2628 C CA  . HIS B 2 51  ? -22.36209 -28.80374 -1.00459  1.000 19.98436 ? 51  HIS B CA  1 
ATOM   2629 C C   . HIS B 2 51  ? -21.24458 -28.50009 -0.01364  1.000 20.34515 ? 51  HIS B C   1 
ATOM   2630 O O   . HIS B 2 51  ? -20.04788 -28.48491 -0.34213  1.000 18.79590 ? 51  HIS B O   1 
ATOM   2631 C CB  . HIS B 2 51  ? -22.87322 -30.25181 -0.80029  1.000 19.37586 ? 51  HIS B CB  1 
ATOM   2632 C CG  . HIS B 2 51  ? -21.88623 -31.31261 -1.16117  1.000 27.32275 ? 51  HIS B CG  1 
ATOM   2633 N ND1 . HIS B 2 51  ? -21.17830 -32.01909 -0.21168  1.000 26.26101 ? 51  HIS B ND1 1 
ATOM   2634 C CD2 . HIS B 2 51  ? -21.52668 -31.82890 -2.36009  1.000 27.14246 ? 51  HIS B CD2 1 
ATOM   2635 C CE1 . HIS B 2 51  ? -20.39163 -32.89430 -0.81267  1.000 29.76430 ? 51  HIS B CE1 1 
ATOM   2636 N NE2 . HIS B 2 51  ? -20.58544 -32.80078 -2.11683  1.000 36.76551 ? 51  HIS B NE2 1 
ATOM   2637 N N   . SER B 2 52  ? -21.67680 -28.23607 1.21402   1.000 14.27708 ? 52  SER B N   1 
ATOM   2638 C CA  . SER B 2 52  ? -20.80076 -28.03490 2.34926   1.000 14.45379 ? 52  SER B CA  1 
ATOM   2639 C C   . SER B 2 52  ? -20.16825 -29.35064 2.78753   1.000 16.93959 ? 52  SER B C   1 
ATOM   2640 O O   . SER B 2 52  ? -20.62012 -30.44416 2.43872   1.000 16.37995 ? 52  SER B O   1 
ATOM   2641 C CB  . SER B 2 52  ? -21.59231 -27.43750 3.51416   1.000 14.92925 ? 52  SER B CB  1 
ATOM   2642 O OG  . SER B 2 52  ? -22.53833 -28.39979 3.96203   1.000 15.02996 ? 52  SER B OG  1 
ATOM   2643 N N   . ASP B 2 53  ? -19.11580 -29.23151 3.58516   1.000 15.03656 ? 53  ASP B N   1 
ATOM   2644 C CA  . ASP B 2 53  ? -18.41769 -30.40923 4.08026   1.000 13.68354 ? 53  ASP B CA  1 
ATOM   2645 C C   . ASP B 2 53  ? -19.22904 -31.01279 5.21196   1.000 19.45986 ? 53  ASP B C   1 
ATOM   2646 O O   . ASP B 2 53  ? -19.80259 -30.29162 6.03149   1.000 15.42438 ? 53  ASP B O   1 
ATOM   2647 C CB  . ASP B 2 53  ? -17.01911 -30.03797 4.56728   1.000 16.32747 ? 53  ASP B CB  1 
ATOM   2648 C CG  . ASP B 2 53  ? -16.21244 -29.30989 3.50022   1.000 22.92523 ? 53  ASP B CG  1 
ATOM   2649 O OD1 . ASP B 2 53  ? -16.12120 -29.85216 2.38571   1.000 22.09753 ? 53  ASP B OD1 1 
ATOM   2650 O OD2 . ASP B 2 53  ? -15.70750 -28.19037 3.75472   1.000 19.11362 ? 53  ASP B OD2 1 
ATOM   2651 N N   . LEU B 2 54  ? -19.30437 -32.33595 5.22982   1.000 16.45023 ? 54  LEU B N   1 
ATOM   2652 C CA  . LEU B 2 54  ? -20.17380 -33.02511 6.17665   1.000 14.91441 ? 54  LEU B CA  1 
ATOM   2653 C C   . LEU B 2 54  ? -19.80798 -32.67737 7.61424   1.000 16.21481 ? 54  LEU B C   1 
ATOM   2654 O O   . LEU B 2 54  ? -18.63572 -32.67704 7.99684   1.000 15.58432 ? 54  LEU B O   1 
ATOM   2655 C CB  . LEU B 2 54  ? -20.08371 -34.53131 5.95694   1.000 14.89210 ? 54  LEU B CB  1 
ATOM   2656 C CG  . LEU B 2 54  ? -20.87661 -35.37669 6.94366   1.000 15.16163 ? 54  LEU B CG  1 
ATOM   2657 C CD1 . LEU B 2 54  ? -22.35262 -35.14965 6.74807   1.000 17.50218 ? 54  LEU B CD1 1 
ATOM   2658 C CD2 . LEU B 2 54  ? -20.51855 -36.86413 6.79393   1.000 16.46658 ? 54  LEU B CD2 1 
ATOM   2659 N N   . SER B 2 55  ? -20.82213 -32.37966 8.41799   1.000 18.35460 ? 55  SER B N   1 
ATOM   2660 C CA  . SER B 2 55  ? -20.59638 -31.94593 9.79052   1.000 11.45258 ? 55  SER B CA  1 
ATOM   2661 C C   . SER B 2 55  ? -21.77814 -32.44753 10.61894  1.000 12.17680 ? 55  SER B C   1 
ATOM   2662 O O   . SER B 2 55  ? -22.67395 -33.09674 10.08614  1.000 15.28558 ? 55  SER B O   1 
ATOM   2663 C CB  . SER B 2 55  ? -20.40767 -30.42859 9.83239   1.000 13.72455 ? 55  SER B CB  1 
ATOM   2664 O OG  . SER B 2 55  ? -20.02198 -30.00580 11.12516  1.000 24.76033 ? 55  SER B OG  1 
ATOM   2665 N N   . PHE B 2 56  ? -21.77187 -32.19800 11.93262  1.000 14.50388 ? 56  PHE B N   1 
ATOM   2666 C CA  . PHE B 2 56  ? -22.89643 -32.68510 12.74637  1.000 12.32335 ? 56  PHE B CA  1 
ATOM   2667 C C   . PHE B 2 56  ? -23.08608 -31.84631 14.00339  1.000 17.40206 ? 56  PHE B C   1 
ATOM   2668 O O   . PHE B 2 56  ? -22.21848 -31.05366 14.37599  1.000 15.58523 ? 56  PHE B O   1 
ATOM   2669 C CB  . PHE B 2 56  ? -22.71860 -34.16603 13.10218  1.000 16.30837 ? 56  PHE B CB  1 
ATOM   2670 C CG  . PHE B 2 56  ? -21.37844 -34.50610 13.69550  1.000 14.20336 ? 56  PHE B CG  1 
ATOM   2671 C CD1 . PHE B 2 56  ? -21.11558 -34.25612 15.04889  1.000 14.90652 ? 56  PHE B CD1 1 
ATOM   2672 C CD2 . PHE B 2 56  ? -20.39989 -35.11785 12.92169  1.000 18.65081 ? 56  PHE B CD2 1 
ATOM   2673 C CE1 . PHE B 2 56  ? -19.89033 -34.58877 15.60901  1.000 16.38870 ? 56  PHE B CE1 1 
ATOM   2674 C CE2 . PHE B 2 56  ? -19.17823 -35.45408 13.48162  1.000 13.95277 ? 56  PHE B CE2 1 
ATOM   2675 C CZ  . PHE B 2 56  ? -18.94151 -35.21116 14.83448  1.000 16.39867 ? 56  PHE B CZ  1 
ATOM   2676 N N   . SER B 2 57  ? -24.26277 -32.02835 14.65846  1.000 15.42603 ? 57  SER B N   1 
ATOM   2677 C CA  . SER B 2 57  ? -24.70844 -31.21392 15.77860  1.000 20.83931 ? 57  SER B CA  1 
ATOM   2678 C C   . SER B 2 57  ? -24.39985 -31.92836 17.07283  1.000 18.62598 ? 57  SER B C   1 
ATOM   2679 O O   . SER B 2 57  ? -23.82700 -33.01247 17.09885  1.000 18.24405 ? 57  SER B O   1 
ATOM   2680 C CB  . SER B 2 57  ? -26.21261 -30.89944 15.70569  1.000 18.04789 ? 57  SER B CB  1 
ATOM   2681 O OG  . SER B 2 57  ? -26.58426 -30.42485 14.43708  1.000 17.99831 ? 57  SER B OG  1 
ATOM   2682 N N   . LYS B 2 58  ? -24.83343 -31.33853 18.17613  1.000 22.29291 ? 58  LYS B N   1 
ATOM   2683 C CA  . LYS B 2 58  ? -24.42602 -31.86348 19.47613  1.000 24.32704 ? 58  LYS B CA  1 
ATOM   2684 C C   . LYS B 2 58  ? -25.01551 -33.24678 19.69673  1.000 23.49395 ? 58  LYS B C   1 
ATOM   2685 O O   . LYS B 2 58  ? -24.43492 -34.07587 20.40749  1.000 29.11901 ? 58  LYS B O   1 
ATOM   2686 C CB  . LYS B 2 58  ? -24.89096 -30.93352 20.61045  1.000 29.32246 ? 58  LYS B CB  1 
ATOM   2687 C CG  . LYS B 2 58  ? -24.18568 -29.51498 20.79532  1.000 35.94705 ? 58  LYS B CG  1 
ATOM   2688 C CD  . LYS B 2 58  ? -24.37668 -28.60411 19.61768  1.000 42.55539 ? 58  LYS B CD  1 
ATOM   2689 C CE  . LYS B 2 58  ? -25.75481 -28.78391 19.04001  1.000 43.60740 ? 58  LYS B CE  1 
ATOM   2690 N NZ  . LYS B 2 58  ? -26.10515 -27.61530 18.15097  1.000 37.08079 ? 58  LYS B NZ  1 
ATOM   2691 N N   . ASP B 2 59  ? -26.19234 -33.50046 19.12534  1.000 18.35288 ? 59  ASP B N   1 
ATOM   2692 C CA  . ASP B 2 59  ? -26.82781 -34.80198 19.28389  1.000 24.41157 ? 59  ASP B CA  1 
ATOM   2693 C C   . ASP B 2 59  ? -26.26475 -35.83558 18.32834  1.000 19.34834 ? 59  ASP B C   1 
ATOM   2694 O O   . ASP B 2 59  ? -26.78583 -36.95047 18.25768  1.000 16.29200 ? 59  ASP B O   1 
ATOM   2695 C CB  . ASP B 2 59  ? -28.35008 -34.70257 19.11682  1.000 18.07026 ? 59  ASP B CB  1 
ATOM   2696 C CG  . ASP B 2 59  ? -28.78376 -34.18031 17.76085  1.000 27.77195 ? 59  ASP B CG  1 
ATOM   2697 O OD1 . ASP B 2 59  ? -27.95266 -34.07636 16.84168  1.000 23.41442 ? 59  ASP B OD1 1 
ATOM   2698 O OD2 . ASP B 2 59  ? -29.99443 -33.88657 17.60865  1.000 26.32070 ? 59  ASP B OD2 1 
ATOM   2699 N N   . TRP B 2 60  ? -25.21476 -35.47525 17.59783  1.000 20.59943 ? 60  TRP B N   1 
ATOM   2700 C CA  . TRP B 2 60  ? -24.47362 -36.29432 16.64671  1.000 16.25950 ? 60  TRP B CA  1 
ATOM   2701 C C   . TRP B 2 60  ? -25.16220 -36.42236 15.28572  1.000 18.17220 ? 60  TRP B C   1 
ATOM   2702 O O   . TRP B 2 60  ? -24.61817 -37.11721 14.42364  1.000 14.78501 ? 60  TRP B O   1 
ATOM   2703 C CB  . TRP B 2 60  ? -24.17307 -37.70499 17.16841  1.000 16.54218 ? 60  TRP B CB  1 
ATOM   2704 C CG  . TRP B 2 60  ? -23.43356 -37.73979 18.48777  1.000 15.54663 ? 60  TRP B CG  1 
ATOM   2705 C CD1 . TRP B 2 60  ? -23.95622 -38.02293 19.71851  1.000 15.90751 ? 60  TRP B CD1 1 
ATOM   2706 C CD2 . TRP B 2 60  ? -22.03423 -37.53002 18.68682  1.000 19.95263 ? 60  TRP B CD2 1 
ATOM   2707 N NE1 . TRP B 2 60  ? -22.97404 -37.97642 20.67413  1.000 18.84229 ? 60  TRP B NE1 1 
ATOM   2708 C CE2 . TRP B 2 60  ? -21.78109 -37.67755 20.07110  1.000 17.53952 ? 60  TRP B CE2 1 
ATOM   2709 C CE3 . TRP B 2 60  ? -20.97108 -37.21931 17.83241  1.000 15.97426 ? 60  TRP B CE3 1 
ATOM   2710 C CZ2 . TRP B 2 60  ? -20.50043 -37.53766 20.61520  1.000 24.06551 ? 60  TRP B CZ2 1 
ATOM   2711 C CZ3 . TRP B 2 60  ? -19.69663 -37.08226 18.37358  1.000 17.60786 ? 60  TRP B CZ3 1 
ATOM   2712 C CH2 . TRP B 2 60  ? -19.47400 -37.23441 19.74775  1.000 17.45720 ? 60  TRP B CH2 1 
ATOM   2713 N N   . SER B 2 61  ? -26.31113 -35.78251 15.05013  1.000 15.68463 ? 61  SER B N   1 
ATOM   2714 C CA  . SER B 2 61  ? -26.98154 -35.91816 13.76584  1.000 17.03240 ? 61  SER B CA  1 
ATOM   2715 C C   . SER B 2 61  ? -26.33975 -34.98633 12.75172  1.000 14.43089 ? 61  SER B C   1 
ATOM   2716 O O   . SER B 2 61  ? -25.87367 -33.90299 13.09385  1.000 11.76324 ? 61  SER B O   1 
ATOM   2717 C CB  . SER B 2 61  ? -28.47471 -35.59011 13.88076  1.000 14.47166 ? 61  SER B CB  1 
ATOM   2718 O OG  . SER B 2 61  ? -28.65909 -34.29228 14.40741  1.000 17.69769 ? 61  SER B OG  1 
ATOM   2719 N N   . PHE B 2 62  ? -26.34880 -35.40661 11.48771  1.000 12.74867 ? 62  PHE B N   1 
ATOM   2720 C CA  . PHE B 2 62  ? -25.61373 -34.71171 10.43996  1.000 12.21510 ? 62  PHE B CA  1 
ATOM   2721 C C   . PHE B 2 62  ? -26.41195 -33.55257 9.84306   1.000 16.82480 ? 62  PHE B C   1 
ATOM   2722 O O   . PHE B 2 62  ? -27.64335 -33.52294 9.88589   1.000 15.80389 ? 62  PHE B O   1 
ATOM   2723 C CB  . PHE B 2 62  ? -25.24203 -35.70073 9.33956   1.000 16.65659 ? 62  PHE B CB  1 
ATOM   2724 C CG  . PHE B 2 62  ? -24.30108 -36.78705 9.80035   1.000 16.69200 ? 62  PHE B CG  1 
ATOM   2725 C CD1 . PHE B 2 62  ? -22.96037 -36.52679 9.96079   1.000 14.56421 ? 62  PHE B CD1 1 
ATOM   2726 C CD2 . PHE B 2 62  ? -24.76548 -38.05390 10.09462  1.000 18.14372 ? 62  PHE B CD2 1 
ATOM   2727 C CE1 . PHE B 2 62  ? -22.07697 -37.51503 10.38788  1.000 15.60711 ? 62  PHE B CE1 1 
ATOM   2728 C CE2 . PHE B 2 62  ? -23.88341 -39.04985 10.52563  1.000 16.71650 ? 62  PHE B CE2 1 
ATOM   2729 C CZ  . PHE B 2 62  ? -22.53952 -38.77444 10.65838  1.000 18.54922 ? 62  PHE B CZ  1 
ATOM   2730 N N   . TYR B 2 63  ? -25.68443 -32.58289 9.27136   1.000 13.05631 ? 63  TYR B N   1 
ATOM   2731 C CA  . TYR B 2 63  ? -26.30284 -31.55760 8.45071   1.000 15.97134 ? 63  TYR B CA  1 
ATOM   2732 C C   . TYR B 2 63  ? -25.41827 -31.25394 7.24940   1.000 16.72070 ? 63  TYR B C   1 
ATOM   2733 O O   . TYR B 2 63  ? -24.18442 -31.34971 7.31194   1.000 15.44974 ? 63  TYR B O   1 
ATOM   2734 C CB  . TYR B 2 63  ? -26.60496 -30.27040 9.23082   1.000 15.50051 ? 63  TYR B CB  1 
ATOM   2735 C CG  . TYR B 2 63  ? -25.41664 -29.62867 9.90788   1.000 17.19989 ? 63  TYR B CG  1 
ATOM   2736 C CD1 . TYR B 2 63  ? -24.60254 -28.74207 9.22504   1.000 15.64168 ? 63  TYR B CD1 1 
ATOM   2737 C CD2 . TYR B 2 63  ? -25.12867 -29.89173 11.23465  1.000 15.47233 ? 63  TYR B CD2 1 
ATOM   2738 C CE1 . TYR B 2 63  ? -23.50731 -28.14605 9.83693   1.000 16.27545 ? 63  TYR B CE1 1 
ATOM   2739 C CE2 . TYR B 2 63  ? -24.04268 -29.30301 11.85748  1.000 18.13972 ? 63  TYR B CE2 1 
ATOM   2740 C CZ  . TYR B 2 63  ? -23.23257 -28.43291 11.14539  1.000 16.81603 ? 63  TYR B CZ  1 
ATOM   2741 O OH  . TYR B 2 63  ? -22.15116 -27.84131 11.75425  1.000 20.48880 ? 63  TYR B OH  1 
ATOM   2742 N N   . LEU B 2 64  ? -26.07743 -30.90153 6.14873   1.000 15.63894 ? 64  LEU B N   1 
ATOM   2743 C CA  . LEU B 2 64  ? -25.42928 -30.51244 4.90917   1.000 14.89233 ? 64  LEU B CA  1 
ATOM   2744 C C   . LEU B 2 64  ? -26.21945 -29.39628 4.27154   1.000 15.98403 ? 64  LEU B C   1 
ATOM   2745 O O   . LEU B 2 64  ? -27.45694 -29.34693 4.36187   1.000 16.59949 ? 64  LEU B O   1 
ATOM   2746 C CB  . LEU B 2 64  ? -25.32452 -31.64510 3.88608   1.000 13.22404 ? 64  LEU B CB  1 
ATOM   2747 C CG  . LEU B 2 64  ? -24.37841 -32.79839 4.19741   1.000 16.42404 ? 64  LEU B CG  1 
ATOM   2748 C CD1 . LEU B 2 64  ? -24.70405 -33.97990 3.30320   1.000 13.99698 ? 64  LEU B CD1 1 
ATOM   2749 C CD2 . LEU B 2 64  ? -22.91578 -32.35692 3.99043   1.000 16.73624 ? 64  LEU B CD2 1 
ATOM   2750 N N   . LEU B 2 65  ? -25.49242 -28.52931 3.59041   1.000 13.61261 ? 65  LEU B N   1 
ATOM   2751 C CA  . LEU B 2 65  ? -26.07469 -27.46915 2.79218   1.000 14.64779 ? 65  LEU B CA  1 
ATOM   2752 C C   . LEU B 2 65  ? -25.67664 -27.72476 1.34640   1.000 16.83922 ? 65  LEU B C   1 
ATOM   2753 O O   . LEU B 2 65  ? -24.47810 -27.83257 1.03748   1.000 19.23908 ? 65  LEU B O   1 
ATOM   2754 C CB  . LEU B 2 65  ? -25.60288 -26.09404 3.26526   1.000 11.05562 ? 65  LEU B CB  1 
ATOM   2755 C CG  . LEU B 2 65  ? -26.10901 -24.98642 2.35453   1.000 14.35537 ? 65  LEU B CG  1 
ATOM   2756 C CD1 . LEU B 2 65  ? -27.60056 -24.91503 2.56366   1.000 14.12327 ? 65  LEU B CD1 1 
ATOM   2757 C CD2 . LEU B 2 65  ? -25.49997 -23.66027 2.72665   1.000 16.84499 ? 65  LEU B CD2 1 
ATOM   2758 N N   . TYR B 2 66  ? -26.67721 -27.89761 0.48804   1.000 15.65837 ? 66  TYR B N   1 
ATOM   2759 C CA  . TYR B 2 66  ? -26.50807 -27.89552 -0.96537  1.000 14.37780 ? 66  TYR B CA  1 
ATOM   2760 C C   . TYR B 2 66  ? -26.96363 -26.55874 -1.53119  1.000 18.93417 ? 66  TYR B C   1 
ATOM   2761 O O   . TYR B 2 66  ? -27.99486 -26.02537 -1.11459  1.000 15.05627 ? 66  TYR B O   1 
ATOM   2762 C CB  . TYR B 2 66  ? -27.31659 -29.02726 -1.60999  1.000 15.37110 ? 66  TYR B CB  1 
ATOM   2763 C CG  . TYR B 2 66  ? -26.77699 -30.40201 -1.32075  1.000 15.01779 ? 66  TYR B CG  1 
ATOM   2764 C CD1 . TYR B 2 66  ? -26.86218 -30.95746 -0.05339  1.000 18.29308 ? 66  TYR B CD1 1 
ATOM   2765 C CD2 . TYR B 2 66  ? -26.15399 -31.13484 -2.31929  1.000 19.12478 ? 66  TYR B CD2 1 
ATOM   2766 C CE1 . TYR B 2 66  ? -26.33983 -32.21093 0.21423   1.000 21.55514 ? 66  TYR B CE1 1 
ATOM   2767 C CE2 . TYR B 2 66  ? -25.63096 -32.39469 -2.06310  1.000 19.17233 ? 66  TYR B CE2 1 
ATOM   2768 C CZ  . TYR B 2 66  ? -25.73283 -32.92239 -0.79308  1.000 21.88631 ? 66  TYR B CZ  1 
ATOM   2769 O OH  . TYR B 2 66  ? -25.23363 -34.16847 -0.52467  1.000 28.84782 ? 66  TYR B OH  1 
ATOM   2770 N N   . TYR B 2 67  ? -26.22581 -26.02429 -2.50687  1.000 11.50684 ? 67  TYR B N   1 
ATOM   2771 C CA  . TYR B 2 67  ? -26.58385 -24.69729 -2.97980  1.000 18.81210 ? 67  TYR B CA  1 
ATOM   2772 C C   . TYR B 2 67  ? -26.18359 -24.53108 -4.43975  1.000 17.87263 ? 67  TYR B C   1 
ATOM   2773 O O   . TYR B 2 67  ? -25.31620 -25.24104 -4.95374  1.000 22.79369 ? 67  TYR B O   1 
ATOM   2774 C CB  . TYR B 2 67  ? -25.94282 -23.61118 -2.10596  1.000 15.24714 ? 67  TYR B CB  1 
ATOM   2775 C CG  . TYR B 2 67  ? -24.43925 -23.71897 -2.04607  1.000 22.81492 ? 67  TYR B CG  1 
ATOM   2776 C CD1 . TYR B 2 67  ? -23.81234 -24.50610 -1.08531  1.000 19.98245 ? 67  TYR B CD1 1 
ATOM   2777 C CD2 . TYR B 2 67  ? -23.64467 -23.05611 -2.97425  1.000 22.74456 ? 67  TYR B CD2 1 
ATOM   2778 C CE1 . TYR B 2 67  ? -22.41786 -24.61538 -1.04567  1.000 21.08508 ? 67  TYR B CE1 1 
ATOM   2779 C CE2 . TYR B 2 67  ? -22.24938 -23.15632 -2.94251  1.000 25.96736 ? 67  TYR B CE2 1 
ATOM   2780 C CZ  . TYR B 2 67  ? -21.64828 -23.94122 -1.98277  1.000 29.69183 ? 67  TYR B CZ  1 
ATOM   2781 O OH  . TYR B 2 67  ? -20.27214 -24.04453 -1.94639  1.000 29.11174 ? 67  TYR B OH  1 
ATOM   2782 N N   . THR B 2 68  ? -26.81239 -23.56338 -5.09607  1.000 16.99407 ? 68  THR B N   1 
ATOM   2783 C CA  . THR B 2 68  ? -26.45920 -23.21516 -6.46541  1.000 21.40972 ? 68  THR B CA  1 
ATOM   2784 C C   . THR B 2 68  ? -26.83184 -21.75817 -6.71128  1.000 18.72522 ? 68  THR B C   1 
ATOM   2785 O O   . THR B 2 68  ? -27.80924 -21.24024 -6.15186  1.000 18.51399 ? 68  THR B O   1 
ATOM   2786 C CB  . THR B 2 68  ? -27.14147 -24.13059 -7.50498  1.000 20.95570 ? 68  THR B CB  1 
ATOM   2787 O OG1 . THR B 2 68  ? -26.57321 -23.88018 -8.79832  1.000 24.92071 ? 68  THR B OG1 1 
ATOM   2788 C CG2 . THR B 2 68  ? -28.65702 -23.86359 -7.59137  1.000 22.15312 ? 68  THR B CG2 1 
ATOM   2789 N N   . GLU B 2 69  ? -26.02143 -21.08715 -7.51964  1.000 22.66151 ? 69  GLU B N   1 
ATOM   2790 C CA  . GLU B 2 69  ? -26.39987 -19.76546 -7.99573  1.000 24.52229 ? 69  GLU B CA  1 
ATOM   2791 C C   . GLU B 2 69  ? -27.55754 -19.87640 -8.96558  1.000 23.24224 ? 69  GLU B C   1 
ATOM   2792 O O   . GLU B 2 69  ? -27.59633 -20.76883 -9.81538  1.000 30.34493 ? 69  GLU B O   1 
ATOM   2793 C CB  . GLU B 2 69  ? -25.24847 -19.05628 -8.69903  1.000 24.93991 ? 69  GLU B CB  1 
ATOM   2794 C CG  . GLU B 2 69  ? -25.23961 -17.56479 -8.39788  1.000 31.54571 ? 69  GLU B CG  1 
ATOM   2795 C CD  . GLU B 2 69  ? -24.51396 -16.72366 -9.44322  1.000 49.45963 ? 69  GLU B CD  1 
ATOM   2796 O OE1 . GLU B 2 69  ? -24.66814 -16.99507 -10.65980 1.000 52.90465 ? 69  GLU B OE1 1 
ATOM   2797 O OE2 . GLU B 2 69  ? -23.77686 -15.78977 -9.03748  1.000 51.70574 ? 69  GLU B OE2 1 
ATOM   2798 N N   . PHE B 2 70  ? -28.49534 -18.94953 -8.85952  1.000 23.13274 ? 70  PHE B N   1 
ATOM   2799 C CA  . PHE B 2 70  ? -29.60009 -18.94590 -9.80191  1.000 22.32991 ? 70  PHE B CA  1 
ATOM   2800 C C   . PHE B 2 70  ? -30.17692 -17.54497 -9.86118  1.000 23.24528 ? 70  PHE B C   1 
ATOM   2801 O O   . PHE B 2 70  ? -29.84019 -16.67642 -9.05417  1.000 23.75825 ? 70  PHE B O   1 
ATOM   2802 C CB  . PHE B 2 70  ? -30.66134 -19.99440 -9.44097  1.000 21.12166 ? 70  PHE B CB  1 
ATOM   2803 C CG  . PHE B 2 70  ? -31.61660 -19.58106 -8.35364  1.000 26.73218 ? 70  PHE B CG  1 
ATOM   2804 C CD1 . PHE B 2 70  ? -31.17012 -18.98023 -7.18391  1.000 24.22031 ? 70  PHE B CD1 1 
ATOM   2805 C CD2 . PHE B 2 70  ? -32.97362 -19.85088 -8.48213  1.000 26.21027 ? 70  PHE B CD2 1 
ATOM   2806 C CE1 . PHE B 2 70  ? -32.06508 -18.62124 -6.18900  1.000 23.12808 ? 70  PHE B CE1 1 
ATOM   2807 C CE2 . PHE B 2 70  ? -33.86879 -19.49277 -7.48464  1.000 30.14919 ? 70  PHE B CE2 1 
ATOM   2808 C CZ  . PHE B 2 70  ? -33.41036 -18.88430 -6.33838  1.000 26.25273 ? 70  PHE B CZ  1 
ATOM   2809 N N   . THR B 2 71  ? -31.01902 -17.33615 -10.86571 1.000 27.60380 ? 71  THR B N   1 
ATOM   2810 C CA  . THR B 2 71  ? -31.77700 -16.10183 -11.03694 1.000 26.52398 ? 71  THR B CA  1 
ATOM   2811 C C   . THR B 2 71  ? -33.24383 -16.49718 -11.13144 1.000 27.83309 ? 71  THR B C   1 
ATOM   2812 O O   . THR B 2 71  ? -33.66234 -17.08061 -12.15344 1.000 25.23311 ? 71  THR B O   1 
ATOM   2813 C CB  . THR B 2 71  ? -31.31021 -15.32658 -12.26810 1.000 26.46176 ? 71  THR B CB  1 
ATOM   2814 O OG1 . THR B 2 71  ? -29.93260 -14.95811 -12.10976 1.000 29.59475 ? 71  THR B OG1 1 
ATOM   2815 C CG2 . THR B 2 71  ? -32.11984 -14.07908 -12.45542 1.000 24.93392 ? 71  THR B CG2 1 
ATOM   2816 N N   . PRO B 2 72  ? -34.03760 -16.24571 -10.09460 1.000 28.85394 ? 72  PRO B N   1 
ATOM   2817 C CA  . PRO B 2 72  ? -35.45568 -16.60647 -10.15083 1.000 28.97362 ? 72  PRO B CA  1 
ATOM   2818 C C   . PRO B 2 72  ? -36.19311 -15.84166 -11.24172 1.000 30.60944 ? 72  PRO B C   1 
ATOM   2819 O O   . PRO B 2 72  ? -35.86662 -14.69679 -11.56554 1.000 28.83272 ? 72  PRO B O   1 
ATOM   2820 C CB  . PRO B 2 72  ? -35.97878 -16.24465 -8.75564  1.000 29.25058 ? 72  PRO B CB  1 
ATOM   2821 C CG  . PRO B 2 72  ? -34.89618 -15.46396 -8.08030  1.000 26.42954 ? 72  PRO B CG  1 
ATOM   2822 C CD  . PRO B 2 72  ? -33.67972 -15.44053 -8.91441  1.000 26.81521 ? 72  PRO B CD  1 
ATOM   2823 N N   . THR B 2 73  ? -37.18270 -16.51424 -11.82614 1.000 31.29017 ? 73  THR B N   1 
ATOM   2824 C CA  . THR B 2 73  ? -38.10160 -15.94612 -12.80117 1.000 32.03774 ? 73  THR B CA  1 
ATOM   2825 C C   . THR B 2 73  ? -39.52817 -16.26625 -12.38537 1.000 37.40588 ? 73  THR B C   1 
ATOM   2826 O O   . THR B 2 73  ? -39.77747 -17.12018 -11.52772 1.000 33.56574 ? 73  THR B O   1 
ATOM   2827 C CB  . THR B 2 73  ? -37.83732 -16.47190 -14.22595 1.000 33.95294 ? 73  THR B CB  1 
ATOM   2828 O OG1 . THR B 2 73  ? -38.36718 -17.79934 -14.35999 1.000 36.12984 ? 73  THR B OG1 1 
ATOM   2829 C CG2 . THR B 2 73  ? -36.35036 -16.46828 -14.55012 1.000 32.13108 ? 73  THR B CG2 1 
ATOM   2830 N N   . GLU B 2 74  ? -40.47188 -15.56905 -13.01946 1.000 40.98412 ? 74  GLU B N   1 
ATOM   2831 C CA  . GLU B 2 74  ? -41.88125 -15.72656 -12.67156 1.000 39.05278 ? 74  GLU B CA  1 
ATOM   2832 C C   . GLU B 2 74  ? -42.38653 -17.14393 -12.92634 1.000 36.43451 ? 74  GLU B C   1 
ATOM   2833 O O   . GLU B 2 74  ? -43.28313 -17.61191 -12.21899 1.000 44.45551 ? 74  GLU B O   1 
ATOM   2834 C CB  . GLU B 2 74  ? -42.71130 -14.70545 -13.45429 1.000 45.61136 ? 74  GLU B CB  1 
ATOM   2835 C CG  . GLU B 2 74  ? -41.89387 -13.46091 -13.84835 1.000 53.00765 ? 74  GLU B CG  1 
ATOM   2836 C CD  . GLU B 2 74  ? -42.72206 -12.33701 -14.47119 1.000 65.28617 ? 74  GLU B CD  1 
ATOM   2837 O OE1 . GLU B 2 74  ? -43.79954 -11.99452 -13.92734 1.000 69.06197 ? 74  GLU B OE1 1 
ATOM   2838 O OE2 . GLU B 2 74  ? -42.26783 -11.76858 -15.48920 1.000 62.66483 ? 74  GLU B OE2 1 
ATOM   2839 N N   . LYS B 2 75  ? -41.81699 -17.85435 -13.90271 1.000 45.42875 ? 75  LYS B N   1 
ATOM   2840 C CA  . LYS B 2 75  ? -42.39807 -19.11088 -14.36462 1.000 46.18962 ? 75  LYS B CA  1 
ATOM   2841 C C   . LYS B 2 75  ? -41.56369 -20.34953 -14.05015 1.000 42.51454 ? 75  LYS B C   1 
ATOM   2842 O O   . LYS B 2 75  ? -41.95721 -21.45596 -14.43617 1.000 43.63454 ? 75  LYS B O   1 
ATOM   2843 C CB  . LYS B 2 75  ? -42.67620 -19.03343 -15.87353 1.000 48.95568 ? 75  LYS B CB  1 
ATOM   2844 C CG  . LYS B 2 75  ? -43.38197 -17.73124 -16.27786 1.000 56.61278 ? 75  LYS B CG  1 
ATOM   2845 C CD  . LYS B 2 75  ? -44.75206 -17.97134 -16.91790 1.000 63.71685 ? 75  LYS B CD  1 
ATOM   2846 C CE  . LYS B 2 75  ? -45.41581 -16.65257 -17.32954 1.000 63.79431 ? 75  LYS B CE  1 
ATOM   2847 N NZ  . LYS B 2 75  ? -46.90873 -16.69775 -17.22075 1.000 64.01243 ? 75  LYS B NZ  1 
ATOM   2848 N N   . ASP B 2 76  ? -40.45532 -20.21701 -13.33310 1.000 36.30794 ? 76  ASP B N   1 
ATOM   2849 C CA  . ASP B 2 76  ? -39.60397 -21.35647 -13.01939 1.000 33.19082 ? 76  ASP B CA  1 
ATOM   2850 C C   . ASP B 2 76  ? -39.91857 -21.86373 -11.61487 1.000 39.99359 ? 76  ASP B C   1 
ATOM   2851 O O   . ASP B 2 76  ? -39.99111 -21.07206 -10.66593 1.000 33.23989 ? 76  ASP B O   1 
ATOM   2852 C CB  . ASP B 2 76  ? -38.13966 -20.94916 -13.13224 1.000 34.71492 ? 76  ASP B CB  1 
ATOM   2853 C CG  . ASP B 2 76  ? -37.65329 -20.98781 -14.55510 1.000 34.45460 ? 76  ASP B CG  1 
ATOM   2854 O OD1 . ASP B 2 76  ? -38.24884 -21.73998 -15.35941 1.000 33.31145 ? 76  ASP B OD1 1 
ATOM   2855 O OD2 . ASP B 2 76  ? -36.72406 -20.21980 -14.88061 1.000 35.79447 ? 76  ASP B OD2 1 
ATOM   2856 N N   . GLU B 2 77  ? -40.12988 -23.17464 -11.48480 1.000 36.55797 ? 77  GLU B N   1 
ATOM   2857 C CA  . GLU B 2 77  ? -40.32767 -23.80079 -10.18171 1.000 34.52524 ? 77  GLU B CA  1 
ATOM   2858 C C   . GLU B 2 77  ? -39.08958 -24.59422 -9.79079  1.000 33.55024 ? 77  GLU B C   1 
ATOM   2859 O O   . GLU B 2 77  ? -38.50823 -25.30824 -10.61350 1.000 31.66746 ? 77  GLU B O   1 
ATOM   2860 C CB  . GLU B 2 77  ? -41.55219 -24.71025 -10.16559 1.000 34.46010 ? 77  GLU B CB  1 
ATOM   2861 C CG  . GLU B 2 77  ? -42.58595 -24.38270 -11.22616 1.000 43.12967 ? 77  GLU B CG  1 
ATOM   2862 C CD  . GLU B 2 77  ? -43.75605 -25.33443 -11.17834 1.000 53.51385 ? 77  GLU B CD  1 
ATOM   2863 O OE1 . GLU B 2 77  ? -43.83733 -26.10344 -10.19232 1.000 59.68525 ? 77  GLU B OE1 1 
ATOM   2864 O OE2 . GLU B 2 77  ? -44.59344 -25.30968 -12.11091 1.000 55.00413 ? 77  GLU B OE2 1 
ATOM   2865 N N   . TYR B 2 78  ? -38.68561 -24.45160 -8.53462  1.000 26.39034 ? 78  TYR B N   1 
ATOM   2866 C CA  . TYR B 2 78  ? -37.50119 -25.11100 -8.01877  1.000 22.54941 ? 78  TYR B CA  1 
ATOM   2867 C C   . TYR B 2 78  ? -37.90528 -26.02453 -6.87532  1.000 21.98046 ? 78  TYR B C   1 
ATOM   2868 O O   . TYR B 2 78  ? -38.90449 -25.78759 -6.18721  1.000 25.60920 ? 78  TYR B O   1 
ATOM   2869 C CB  . TYR B 2 78  ? -36.45432 -24.08462 -7.55005  1.000 17.77278 ? 78  TYR B CB  1 
ATOM   2870 C CG  . TYR B 2 78  ? -35.80235 -23.32083 -8.67334  1.000 26.63706 ? 78  TYR B CG  1 
ATOM   2871 C CD1 . TYR B 2 78  ? -34.65185 -23.80922 -9.29598  1.000 21.54412 ? 78  TYR B CD1 1 
ATOM   2872 C CD2 . TYR B 2 78  ? -36.34020 -22.11758 -9.13283  1.000 32.17870 ? 78  TYR B CD2 1 
ATOM   2873 C CE1 . TYR B 2 78  ? -34.04253 -23.11278 -10.33712 1.000 26.60476 ? 78  TYR B CE1 1 
ATOM   2874 C CE2 . TYR B 2 78  ? -35.74411 -21.42007 -10.19223 1.000 28.28436 ? 78  TYR B CE2 1 
ATOM   2875 C CZ  . TYR B 2 78  ? -34.59535 -21.92287 -10.77813 1.000 32.22944 ? 78  TYR B CZ  1 
ATOM   2876 O OH  . TYR B 2 78  ? -33.99458 -21.23391 -11.81005 1.000 32.42472 ? 78  TYR B OH  1 
ATOM   2877 N N   . ALA B 2 79  ? -37.12278 -27.07659 -6.68109  1.000 24.43521 ? 79  ALA B N   1 
ATOM   2878 C CA  . ALA B 2 79  ? -37.37604 -28.00119 -5.58880  1.000 20.92726 ? 79  ALA B CA  1 
ATOM   2879 C C   . ALA B 2 79  ? -36.07822 -28.71256 -5.23099  1.000 20.81050 ? 79  ALA B C   1 
ATOM   2880 O O   . ALA B 2 79  ? -35.06907 -28.62743 -5.93937  1.000 19.04523 ? 79  ALA B O   1 
ATOM   2881 C CB  . ALA B 2 79  ? -38.48193 -28.99884 -5.94669  1.000 23.77419 ? 79  ALA B CB  1 
ATOM   2882 N N   . CYS B 2 80  ? -36.11551 -29.37679 -4.08447  1.000 18.17910 ? 80  CYS B N   1 
ATOM   2883 C CA  . CYS B 2 80  ? -35.02240 -30.17832 -3.57363  1.000 19.46405 ? 80  CYS B CA  1 
ATOM   2884 C C   . CYS B 2 80  ? -35.55745 -31.59118 -3.39674  1.000 22.24532 ? 80  CYS B C   1 
ATOM   2885 O O   . CYS B 2 80  ? -36.63517 -31.77864 -2.81669  1.000 23.14777 ? 80  CYS B O   1 
ATOM   2886 C CB  . CYS B 2 80  ? -34.51648 -29.60946 -2.24799  1.000 20.99637 ? 80  CYS B CB  1 
ATOM   2887 S SG  . CYS B 2 80  ? -33.13803 -30.50495 -1.57179  1.000 32.45709 ? 80  CYS B SG  1 
ATOM   2888 N N   . ARG B 2 81  ? -34.83978 -32.56569 -3.93978  1.000 15.81774 ? 81  ARG B N   1 
ATOM   2889 C CA  . ARG B 2 81  ? -35.21211 -33.97185 -3.86089  1.000 15.65298 ? 81  ARG B CA  1 
ATOM   2890 C C   . ARG B 2 81  ? -34.21098 -34.65635 -2.94767  1.000 18.25341 ? 81  ARG B C   1 
ATOM   2891 O O   . ARG B 2 81  ? -33.01558 -34.70402 -3.26349  1.000 19.32413 ? 81  ARG B O   1 
ATOM   2892 C CB  . ARG B 2 81  ? -35.20948 -34.61579 -5.24791  1.000 17.40045 ? 81  ARG B CB  1 
ATOM   2893 C CG  . ARG B 2 81  ? -35.41936 -36.12277 -5.22995  1.000 19.41744 ? 81  ARG B CG  1 
ATOM   2894 C CD  . ARG B 2 81  ? -35.30376 -36.75920 -6.61777  1.000 20.58120 ? 81  ARG B CD  1 
ATOM   2895 N NE  . ARG B 2 81  ? -33.92965 -36.74290 -7.09460  1.000 16.67183 ? 81  ARG B NE  1 
ATOM   2896 C CZ  . ARG B 2 81  ? -33.56416 -36.69652 -8.37437  1.000 21.25276 ? 81  ARG B CZ  1 
ATOM   2897 N NH1 . ARG B 2 81  ? -34.45582 -36.74659 -9.35067  1.000 22.63637 ? 81  ARG B NH1 1 
ATOM   2898 N NH2 . ARG B 2 81  ? -32.26800 -36.66364 -8.67775  1.000 20.54082 ? 81  ARG B NH2 1 
ATOM   2899 N N   . VAL B 2 82  ? -34.68398 -35.16703 -1.81311  1.000 17.17749 ? 82  VAL B N   1 
ATOM   2900 C CA  . VAL B 2 82  ? -33.81160 -35.74438 -0.80169  1.000 16.54681 ? 82  VAL B CA  1 
ATOM   2901 C C   . VAL B 2 82  ? -34.05078 -37.24307 -0.74289  1.000 17.56326 ? 82  VAL B C   1 
ATOM   2902 O O   . VAL B 2 82  ? -35.19522 -37.69190 -0.59055  1.000 19.54799 ? 82  VAL B O   1 
ATOM   2903 C CB  . VAL B 2 82  ? -34.02159 -35.09849 0.57946   1.000 18.27414 ? 82  VAL B CB  1 
ATOM   2904 C CG1 . VAL B 2 82  ? -33.16615 -35.82047 1.61899   1.000 18.84989 ? 82  VAL B CG1 1 
ATOM   2905 C CG2 . VAL B 2 82  ? -33.67905 -33.62917 0.51129   1.000 20.74413 ? 82  VAL B CG2 1 
ATOM   2906 N N   . ASN B 2 83  ? -32.96164 -38.00090 -0.83185  1.000 15.44383 ? 83  ASN B N   1 
ATOM   2907 C CA  . ASN B 2 83  ? -32.96798 -39.45164 -0.93442  1.000 16.13128 ? 83  ASN B CA  1 
ATOM   2908 C C   . ASN B 2 83  ? -32.15843 -39.99642 0.23844   1.000 18.65339 ? 83  ASN B C   1 
ATOM   2909 O O   . ASN B 2 83  ? -30.96328 -39.69437 0.37421   1.000 19.93468 ? 83  ASN B O   1 
ATOM   2910 C CB  . ASN B 2 83  ? -32.41071 -39.87332 -2.30452  1.000 15.36812 ? 83  ASN B CB  1 
ATOM   2911 C CG  . ASN B 2 83  ? -32.45809 -41.36616 -2.54401  1.000 17.81606 ? 83  ASN B CG  1 
ATOM   2912 O OD1 . ASN B 2 83  ? -33.34721 -42.04916 -2.05406  1.000 19.64710 ? 83  ASN B OD1 1 
ATOM   2913 N ND2 . ASN B 2 83  ? -31.52718 -41.87664 -3.38360  1.000 17.74350 ? 83  ASN B ND2 1 
ATOM   2914 N N   . HIS B 2 84  ? -32.82598 -40.75818 1.10774   1.000 16.10368 ? 84  HIS B N   1 
ATOM   2915 C CA  . HIS B 2 84  ? -32.28130 -41.21899 2.37760   1.000 19.23782 ? 84  HIS B CA  1 
ATOM   2916 C C   . HIS B 2 84  ? -32.96551 -42.52488 2.76785   1.000 17.54243 ? 84  HIS B C   1 
ATOM   2917 O O   . HIS B 2 84  ? -34.14079 -42.74335 2.45515   1.000 19.28033 ? 84  HIS B O   1 
ATOM   2918 C CB  . HIS B 2 84  ? -32.48541 -40.18079 3.49857   1.000 17.34343 ? 84  HIS B CB  1 
ATOM   2919 C CG  . HIS B 2 84  ? -31.66111 -40.45216 4.71689   1.000 20.19150 ? 84  HIS B CG  1 
ATOM   2920 N ND1 . HIS B 2 84  ? -32.21276 -40.88029 5.90358   1.000 18.82757 ? 84  HIS B ND1 1 
ATOM   2921 C CD2 . HIS B 2 84  ? -30.32534 -40.34617 4.93789   1.000 18.99373 ? 84  HIS B CD2 1 
ATOM   2922 C CE1 . HIS B 2 84  ? -31.25059 -41.05177 6.79706   1.000 21.65067 ? 84  HIS B CE1 1 
ATOM   2923 N NE2 . HIS B 2 84  ? -30.09860 -40.72124 6.24279   1.000 21.71897 ? 84  HIS B NE2 1 
ATOM   2924 N N   . VAL B 2 85  ? -32.22514 -43.38314 3.47548   1.000 17.43132 ? 85  VAL B N   1 
ATOM   2925 C CA  . VAL B 2 85  ? -32.72359 -44.70888 3.82284   1.000 15.72179 ? 85  VAL B CA  1 
ATOM   2926 C C   . VAL B 2 85  ? -34.00555 -44.65906 4.65855   1.000 23.19160 ? 85  VAL B C   1 
ATOM   2927 O O   . VAL B 2 85  ? -34.80379 -45.60743 4.62927   1.000 21.00591 ? 85  VAL B O   1 
ATOM   2928 C CB  . VAL B 2 85  ? -31.59848 -45.50675 4.52370   1.000 21.07864 ? 85  VAL B CB  1 
ATOM   2929 C CG1 . VAL B 2 85  ? -31.20351 -44.85242 5.84053   1.000 18.83646 ? 85  VAL B CG1 1 
ATOM   2930 C CG2 . VAL B 2 85  ? -32.04286 -46.94248 4.77750   1.000 23.22132 ? 85  VAL B CG2 1 
ATOM   2931 N N   . THR B 2 86  ? -34.25049 -43.56122 5.37443   1.000 17.62658 ? 86  THR B N   1 
ATOM   2932 C CA  . THR B 2 86  ? -35.46797 -43.44583 6.16281   1.000 20.85597 ? 86  THR B CA  1 
ATOM   2933 C C   . THR B 2 86  ? -36.67423 -42.98790 5.35754   1.000 21.70316 ? 86  THR B C   1 
ATOM   2934 O O   . THR B 2 86  ? -37.77208 -42.89529 5.92077   1.000 24.23907 ? 86  THR B O   1 
ATOM   2935 C CB  . THR B 2 86  ? -35.24966 -42.48191 7.31838   1.000 20.97734 ? 86  THR B CB  1 
ATOM   2936 O OG1 . THR B 2 86  ? -34.97925 -41.18011 6.78554   1.000 18.51317 ? 86  THR B OG1 1 
ATOM   2937 C CG2 . THR B 2 86  ? -34.10504 -42.93463 8.21793   1.000 19.52256 ? 86  THR B CG2 1 
ATOM   2938 N N   . LEU B 2 87  ? -36.51276 -42.67481 4.07641   1.000 16.04304 ? 87  LEU B N   1 
ATOM   2939 C CA  . LEU B 2 87  ? -37.61919 -42.20918 3.25897   1.000 22.85904 ? 87  LEU B CA  1 
ATOM   2940 C C   . LEU B 2 87  ? -37.92271 -43.29753 2.24713   1.000 23.03161 ? 87  LEU B C   1 
ATOM   2941 O O   . LEU B 2 87  ? -37.07083 -43.62749 1.41502   1.000 21.59532 ? 87  LEU B O   1 
ATOM   2942 C CB  . LEU B 2 87  ? -37.28963 -40.88886 2.56935   1.000 21.32684 ? 87  LEU B CB  1 
ATOM   2943 C CG  . LEU B 2 87  ? -36.97859 -39.77377 3.57760   1.000 23.31800 ? 87  LEU B CG  1 
ATOM   2944 C CD1 . LEU B 2 87  ? -36.17776 -38.63510 2.92747   1.000 25.40003 ? 87  LEU B CD1 1 
ATOM   2945 C CD2 . LEU B 2 87  ? -38.21510 -39.25914 4.31812   1.000 23.28331 ? 87  LEU B CD2 1 
ATOM   2946 N N   . SER B 2 88  ? -39.12179 -43.87746 2.33648   1.000 21.49802 ? 88  SER B N   1 
ATOM   2947 C CA  . SER B 2 88  ? -39.45440 -44.97832 1.43730   1.000 23.42202 ? 88  SER B CA  1 
ATOM   2948 C C   . SER B 2 88  ? -39.50551 -44.51368 -0.01641  1.000 21.74201 ? 88  SER B C   1 
ATOM   2949 O O   . SER B 2 88  ? -39.27336 -45.30190 -0.94163  1.000 20.96647 ? 88  SER B O   1 
ATOM   2950 C CB  . SER B 2 88  ? -40.77455 -45.61442 1.87909   1.000 26.93020 ? 88  SER B CB  1 
ATOM   2951 O OG  . SER B 2 88  ? -41.83342 -44.70110 1.71790   1.000 32.12092 ? 88  SER B OG  1 
ATOM   2952 N N   . GLN B 2 89  ? -39.78157 -43.24266 -0.23537  1.000 18.77422 ? 89  GLN B N   1 
ATOM   2953 C CA  . GLN B 2 89  ? -39.66254 -42.58430 -1.52133  1.000 21.71107 ? 89  GLN B CA  1 
ATOM   2954 C C   . GLN B 2 89  ? -38.94298 -41.26495 -1.29294  1.000 21.80919 ? 89  GLN B C   1 
ATOM   2955 O O   . GLN B 2 89  ? -39.05011 -40.68765 -0.21115  1.000 17.66346 ? 89  GLN B O   1 
ATOM   2956 C CB  . GLN B 2 89  ? -41.05624 -42.38446 -2.15835  1.000 19.68169 ? 89  GLN B CB  1 
ATOM   2957 C CG  . GLN B 2 89  ? -41.76286 -41.06238 -1.84492  1.000 19.94382 ? 89  GLN B CG  1 
ATOM   2958 C CD  . GLN B 2 89  ? -43.12482 -40.90071 -2.55368  1.000 26.13455 ? 89  GLN B CD  1 
ATOM   2959 O OE1 . GLN B 2 89  ? -43.19406 -40.73420 -3.77002  1.000 28.56653 ? 89  GLN B OE1 1 
ATOM   2960 N NE2 . GLN B 2 89  ? -44.19678 -40.90355 -1.78317  1.000 28.95971 ? 89  GLN B NE2 1 
ATOM   2961 N N   . PRO B 2 90  ? -38.11925 -40.81958 -2.23831  1.000 19.06306 ? 90  PRO B N   1 
ATOM   2962 C CA  . PRO B 2 90  ? -37.43912 -39.53374 -2.05222  1.000 13.45581 ? 90  PRO B CA  1 
ATOM   2963 C C   . PRO B 2 90  ? -38.43863 -38.42998 -1.76860  1.000 17.93012 ? 90  PRO B C   1 
ATOM   2964 O O   . PRO B 2 90  ? -39.52335 -38.38993 -2.33893  1.000 17.91681 ? 90  PRO B O   1 
ATOM   2965 C CB  . PRO B 2 90  ? -36.71851 -39.31381 -3.38273  1.000 17.16448 ? 90  PRO B CB  1 
ATOM   2966 C CG  . PRO B 2 90  ? -36.45477 -40.71649 -3.88025  1.000 17.53872 ? 90  PRO B CG  1 
ATOM   2967 C CD  . PRO B 2 90  ? -37.66451 -41.52713 -3.44942  1.000 14.03821 ? 90  PRO B CD  1 
ATOM   2968 N N   . LYS B 2 91  ? -38.08593 -37.52118 -0.87870  1.000 18.23667 ? 91  LYS B N   1 
ATOM   2969 C CA  . LYS B 2 91  ? -39.00685 -36.43781 -0.59577  1.000 19.90530 ? 91  LYS B CA  1 
ATOM   2970 C C   . LYS B 2 91  ? -38.62135 -35.22305 -1.42661  1.000 21.34720 ? 91  LYS B C   1 
ATOM   2971 O O   . LYS B 2 91  ? -37.44095 -34.87008 -1.53017  1.000 15.37483 ? 91  LYS B O   1 
ATOM   2972 C CB  . LYS B 2 91  ? -39.08802 -36.13607 0.90282   1.000 22.11338 ? 91  LYS B CB  1 
ATOM   2973 C CG  . LYS B 2 91  ? -39.57939 -34.74630 1.22215   1.000 25.28126 ? 91  LYS B CG  1 
ATOM   2974 C CD  . LYS B 2 91  ? -39.53036 -34.45131 2.71303   1.000 27.88282 ? 91  LYS B CD  1 
ATOM   2975 C CE  . LYS B 2 91  ? -39.63382 -35.72804 3.54484   1.000 34.50134 ? 91  LYS B CE  1 
ATOM   2976 N NZ  . LYS B 2 91  ? -39.59103 -35.49062 5.03508   1.000 38.20902 ? 91  LYS B NZ  1 
ATOM   2977 N N   . ILE B 2 92  ? -39.61667 -34.63820 -2.08084  1.000 18.85892 ? 92  ILE B N   1 
ATOM   2978 C CA  . ILE B 2 92  ? -39.42484 -33.51570 -2.98253  1.000 18.18669 ? 92  ILE B CA  1 
ATOM   2979 C C   . ILE B 2 92  ? -40.12321 -32.32798 -2.35581  1.000 20.58801 ? 92  ILE B C   1 
ATOM   2980 O O   . ILE B 2 92  ? -41.35420 -32.32016 -2.21998  1.000 20.05976 ? 92  ILE B O   1 
ATOM   2981 C CB  . ILE B 2 92  ? -39.96853 -33.80962 -4.38267  1.000 20.54059 ? 92  ILE B CB  1 
ATOM   2982 C CG1 . ILE B 2 92  ? -39.21053 -34.98311 -4.98882  1.000 20.75520 ? 92  ILE B CG1 1 
ATOM   2983 C CG2 . ILE B 2 92  ? -39.89346 -32.53984 -5.27018  1.000 17.11048 ? 92  ILE B CG2 1 
ATOM   2984 C CD1 . ILE B 2 92  ? -39.78339 -35.45604 -6.30509  1.000 23.92522 ? 92  ILE B CD1 1 
ATOM   2985 N N   . VAL B 2 93  ? -39.33464 -31.35045 -1.92179  1.000 17.84648 ? 93  VAL B N   1 
ATOM   2986 C CA  . VAL B 2 93  ? -39.83763 -30.16046 -1.24768  1.000 19.58816 ? 93  VAL B CA  1 
ATOM   2987 C C   . VAL B 2 93  ? -39.74332 -28.99997 -2.22444  1.000 19.44160 ? 93  VAL B C   1 
ATOM   2988 O O   . VAL B 2 93  ? -38.65087 -28.67462 -2.69796  1.000 21.80187 ? 93  VAL B O   1 
ATOM   2989 C CB  . VAL B 2 93  ? -39.04705 -29.87333 0.04374   1.000 24.34275 ? 93  VAL B CB  1 
ATOM   2990 C CG1 . VAL B 2 93  ? -39.59001 -28.64596 0.75076   1.000 26.03306 ? 93  VAL B CG1 1 
ATOM   2991 C CG2 . VAL B 2 93  ? -39.09860 -31.07486 0.97589   1.000 18.97308 ? 93  VAL B CG2 1 
ATOM   2992 N N   . LYS B 2 94  ? -40.88311 -28.38369 -2.54105  1.000 20.07765 ? 94  LYS B N   1 
ATOM   2993 C CA  . LYS B 2 94  ? -40.87618 -27.25691 -3.45901  1.000 21.38956 ? 94  LYS B CA  1 
ATOM   2994 C C   . LYS B 2 94  ? -40.39754 -25.99503 -2.75223  1.000 23.15076 ? 94  LYS B C   1 
ATOM   2995 O O   . LYS B 2 94  ? -40.54498 -25.83799 -1.53694  1.000 25.95702 ? 94  LYS B O   1 
ATOM   2996 C CB  . LYS B 2 94  ? -42.26729 -26.99771 -4.05474  1.000 28.18215 ? 94  LYS B CB  1 
ATOM   2997 C CG  . LYS B 2 94  ? -43.17835 -28.21140 -4.21792  1.000 30.26147 ? 94  LYS B CG  1 
ATOM   2998 C CD  . LYS B 2 94  ? -44.20229 -27.99496 -5.34080  1.000 36.02789 ? 94  LYS B CD  1 
ATOM   2999 C CE  . LYS B 2 94  ? -45.47684 -27.33182 -4.79379  1.000 41.65007 ? 94  LYS B CE  1 
ATOM   3000 N NZ  . LYS B 2 94  ? -46.38059 -26.70798 -5.82464  1.000 44.71430 ? 94  LYS B NZ  1 
ATOM   3001 N N   . TRP B 2 95  ? -39.86295 -25.07404 -3.53739  1.000 18.10306 ? 95  TRP B N   1 
ATOM   3002 C CA  . TRP B 2 95  ? -39.38471 -23.80336 -3.01689  1.000 22.24638 ? 95  TRP B CA  1 
ATOM   3003 C C   . TRP B 2 95  ? -40.55088 -22.84021 -2.87274  1.000 25.64833 ? 95  TRP B C   1 
ATOM   3004 O O   . TRP B 2 95  ? -41.26288 -22.55996 -3.84633  1.000 25.61223 ? 95  TRP B O   1 
ATOM   3005 C CB  . TRP B 2 95  ? -38.31449 -23.20855 -3.92880  1.000 19.03028 ? 95  TRP B CB  1 
ATOM   3006 C CG  . TRP B 2 95  ? -37.88441 -21.83243 -3.50906  1.000 21.03924 ? 95  TRP B CG  1 
ATOM   3007 C CD1 . TRP B 2 95  ? -37.59332 -21.40914 -2.23053  1.000 19.32456 ? 95  TRP B CD1 1 
ATOM   3008 C CD2 . TRP B 2 95  ? -37.65851 -20.70573 -4.36430  1.000 24.50971 ? 95  TRP B CD2 1 
ATOM   3009 N NE1 . TRP B 2 95  ? -37.21277 -20.08280 -2.24688  1.000 20.06329 ? 95  TRP B NE1 1 
ATOM   3010 C CE2 . TRP B 2 95  ? -37.24695 -19.62851 -3.54216  1.000 23.30987 ? 95  TRP B CE2 1 
ATOM   3011 C CE3 . TRP B 2 95  ? -37.75993 -20.50185 -5.74132  1.000 20.87228 ? 95  TRP B CE3 1 
ATOM   3012 C CZ2 . TRP B 2 95  ? -36.95167 -18.36959 -4.05818  1.000 20.26018 ? 95  TRP B CZ2 1 
ATOM   3013 C CZ3 . TRP B 2 95  ? -37.47166 -19.24956 -6.24817  1.000 25.71120 ? 95  TRP B CZ3 1 
ATOM   3014 C CH2 . TRP B 2 95  ? -37.07439 -18.19879 -5.40757  1.000 24.01280 ? 95  TRP B CH2 1 
ATOM   3015 N N   . ASP B 2 96  ? -40.74112 -22.34190 -1.66008  1.000 22.86152 ? 96  ASP B N   1 
ATOM   3016 C CA  . ASP B 2 96  ? -41.76864 -21.35781 -1.34350  1.000 25.48521 ? 96  ASP B CA  1 
ATOM   3017 C C   . ASP B 2 96  ? -41.04561 -20.07758 -0.94947  1.000 23.69607 ? 96  ASP B C   1 
ATOM   3018 O O   . ASP B 2 96  ? -40.26583 -20.07470 0.00800   1.000 27.12652 ? 96  ASP B O   1 
ATOM   3019 C CB  . ASP B 2 96  ? -42.67403 -21.89361 -0.23084  1.000 28.52591 ? 96  ASP B CB  1 
ATOM   3020 C CG  . ASP B 2 96  ? -43.79690 -20.93015 0.17162   1.000 29.54366 ? 96  ASP B CG  1 
ATOM   3021 O OD1 . ASP B 2 96  ? -43.61506 -19.68802 0.17864   1.000 30.20036 ? 96  ASP B OD1 1 
ATOM   3022 O OD2 . ASP B 2 96  ? -44.89841 -21.44849 0.45597   1.000 30.12777 ? 96  ASP B OD2 1 
ATOM   3023 N N   . ARG B 2 97  ? -41.27479 -19.00354 -1.70157  1.000 19.78107 ? 97  ARG B N   1 
ATOM   3024 C CA  . ARG B 2 97  ? -40.47967 -17.79650 -1.48866  1.000 23.95408 ? 97  ARG B CA  1 
ATOM   3025 C C   . ARG B 2 97  ? -40.72419 -17.11289 -0.14082  1.000 26.00184 ? 97  ARG B C   1 
ATOM   3026 O O   . ARG B 2 97  ? -40.05265 -16.11983 0.14805   1.000 25.73013 ? 97  ARG B O   1 
ATOM   3027 C CB  . ARG B 2 97  ? -40.72279 -16.80668 -2.62260  1.000 25.89234 ? 97  ARG B CB  1 
ATOM   3028 C CG  . ARG B 2 97  ? -40.78156 -17.45638 -3.99021  1.000 29.28932 ? 97  ARG B CG  1 
ATOM   3029 C CD  . ARG B 2 97  ? -41.11630 -16.42599 -5.07851  1.000 28.79766 ? 97  ARG B CD  1 
ATOM   3030 N NE  . ARG B 2 97  ? -40.77211 -16.89472 -6.41604  1.000 27.15279 ? 97  ARG B NE  1 
ATOM   3031 C CZ  . ARG B 2 97  ? -40.25148 -16.13453 -7.37020  1.000 31.15476 ? 97  ARG B CZ  1 
ATOM   3032 N NH1 . ARG B 2 97  ? -40.01395 -14.84491 -7.17748  1.000 26.69544 ? 97  ARG B NH1 1 
ATOM   3033 N NH2 . ARG B 2 97  ? -39.97078 -16.67964 -8.55262  1.000 31.00132 ? 97  ARG B NH2 1 
ATOM   3034 N N   . ASP B 2 98  ? -41.67225 -17.57657 0.67755   1.000 25.23276 ? 98  ASP B N   1 
ATOM   3035 C CA  . ASP B 2 98  ? -41.76587 -17.12446 2.06005   1.000 24.72356 ? 98  ASP B CA  1 
ATOM   3036 C C   . ASP B 2 98  ? -41.70751 -18.30535 3.03166   1.000 27.33055 ? 98  ASP B C   1 
ATOM   3037 O O   . ASP B 2 98  ? -42.11105 -18.17227 4.19059   1.000 27.25674 ? 98  ASP B O   1 
ATOM   3038 C CB  . ASP B 2 98  ? -43.03387 -16.28530 2.27194   1.000 24.87615 ? 98  ASP B CB  1 
ATOM   3039 C CG  . ASP B 2 98  ? -43.09565 -15.65281 3.67347   1.000 25.41182 ? 98  ASP B CG  1 
ATOM   3040 O OD1 . ASP B 2 98  ? -42.08545 -15.04501 4.10125   1.000 23.03435 ? 98  ASP B OD1 1 
ATOM   3041 O OD2 . ASP B 2 98  ? -44.13770 -15.78097 4.35036   1.000 22.12175 ? 98  ASP B OD2 1 
ATOM   3042 N N   . MET B 2 99  ? -41.20923 -19.45949 2.57351   1.000 33.00766 ? 99  MET B N   1 
ATOM   3043 C CA  . MET B 2 99  ? -40.99332 -20.65742 3.40021   1.000 28.51421 ? 99  MET B CA  1 
ATOM   3044 C C   . MET B 2 99  ? -42.29523 -21.23529 3.96124   1.000 30.66745 ? 99  MET B C   1 
ATOM   3045 O O   . MET B 2 99  ? -42.93197 -20.64906 4.82416   1.000 36.89570 ? 99  MET B O   1 
ATOM   3046 C CB  . MET B 2 99  ? -39.98891 -20.29822 4.49743   1.000 29.67185 ? 99  MET B CB  1 
ATOM   3047 C CG  . MET B 2 99  ? -38.60538 -20.89589 4.22553   1.000 17.80024 ? 99  MET B CG  1 
ATOM   3048 S SD  . MET B 2 99  ? -38.18444 -20.40837 2.55164   1.000 44.88910 ? 99  MET B SD  1 
ATOM   3049 C CE  . MET B 2 99  ? -37.76124 -18.68128 2.63131   1.000 29.06266 ? 99  MET B CE  1 
ATOM   3050 O OXT . MET B 2 99  ? -42.79877 -22.29863 3.56856   1.000 41.32475 ? 99  MET B OXT 1 
ATOM   3051 N N   . ASN C 3 1   ? -5.61739  -25.85075 15.75925  1.000 17.15668 ? 1   ASN E N   1 
ATOM   3052 C CA  . ASN C 3 1   ? -4.70855  -26.97467 15.65351  1.000 21.20987 ? 1   ASN E CA  1 
ATOM   3053 C C   . ASN C 3 1   ? -5.38698  -28.28276 16.02613  1.000 21.02517 ? 1   ASN E C   1 
ATOM   3054 O O   . ASN C 3 1   ? -6.03501  -28.39996 17.08334  1.000 19.86227 ? 1   ASN E O   1 
ATOM   3055 C CB  . ASN C 3 1   ? -3.46962  -26.75924 16.53540  1.000 18.43854 ? 1   ASN E CB  1 
ATOM   3056 C CG  . ASN C 3 1   ? -2.66059  -25.55808 16.09795  1.000 25.56635 ? 1   ASN E CG  1 
ATOM   3057 O OD1 . ASN C 3 1   ? -2.79261  -24.46498 16.65263  1.000 28.73359 ? 1   ASN E OD1 1 
ATOM   3058 N ND2 . ASN C 3 1   ? -1.86112  -25.73852 15.04462  1.000 30.64927 ? 1   ASN E ND2 1 
ATOM   3059 N N   . TYR C 3 2   ? -5.22033  -29.26720 15.15091  1.000 18.90314 ? 2   TYR E N   1 
ATOM   3060 C CA  . TYR C 3 2   ? -5.64763  -30.62774 15.44244  1.000 18.80102 ? 2   TYR E CA  1 
ATOM   3061 C C   . TYR C 3 2   ? -4.81050  -31.23807 16.57231  1.000 17.43867 ? 2   TYR E C   1 
ATOM   3062 O O   . TYR C 3 2   ? -3.72674  -30.74953 16.92917  1.000 16.34333 ? 2   TYR E O   1 
ATOM   3063 C CB  . TYR C 3 2   ? -5.52893  -31.47619 14.18429  1.000 15.16816 ? 2   TYR E CB  1 
ATOM   3064 C CG  . TYR C 3 2   ? -6.65434  -32.42437 13.91263  1.000 14.83843 ? 2   TYR E CG  1 
ATOM   3065 C CD1 . TYR C 3 2   ? -7.81030  -31.99350 13.27499  1.000 14.17531 ? 2   TYR E CD1 1 
ATOM   3066 C CD2 . TYR C 3 2   ? -6.54634  -33.76526 14.24102  1.000 15.19296 ? 2   TYR E CD2 1 
ATOM   3067 C CE1 . TYR C 3 2   ? -8.85935  -32.87886 13.00126  1.000 14.77745 ? 2   TYR E CE1 1 
ATOM   3068 C CE2 . TYR C 3 2   ? -7.56970  -34.65569 13.95850  1.000 13.90636 ? 2   TYR E CE2 1 
ATOM   3069 C CZ  . TYR C 3 2   ? -8.72755  -34.20079 13.34428  1.000 14.78845 ? 2   TYR E CZ  1 
ATOM   3070 O OH  . TYR C 3 2   ? -9.75970  -35.08250 13.07640  1.000 13.50032 ? 2   TYR E OH  1 
ATOM   3071 N N   . ASN C 3 3   ? -5.33904  -32.31209 17.16053  1.000 12.89163 ? 3   ASN E N   1 
ATOM   3072 C CA  . ASN C 3 3   ? -4.62618  -33.09482 18.16392  1.000 15.91880 ? 3   ASN E CA  1 
ATOM   3073 C C   . ASN C 3 3   ? -4.04942  -34.35420 17.51860  1.000 19.45020 ? 3   ASN E C   1 
ATOM   3074 O O   . ASN C 3 3   ? -4.51178  -34.80606 16.46799  1.000 20.67691 ? 3   ASN E O   1 
ATOM   3075 C CB  . ASN C 3 3   ? -5.57171  -33.47194 19.32711  1.000 18.36816 ? 3   ASN E CB  1 
ATOM   3076 C CG  . ASN C 3 3   ? -4.83361  -34.02328 20.56119  1.000 21.30358 ? 3   ASN E CG  1 
ATOM   3077 O OD1 . ASN C 3 3   ? -3.60422  -33.94365 20.66388  1.000 20.71943 ? 3   ASN E OD1 1 
ATOM   3078 N ND2 . ASN C 3 3   ? -5.60498  -34.53436 21.52984  1.000 17.73434 ? 3   ASN E ND2 1 
ATOM   3079 N N   . TYR C 3 4   ? -3.03008  -34.92431 18.15910  1.000 15.58285 ? 4   TYR E N   1 
ATOM   3080 C CA  . TYR C 3 4   ? -2.52896  -36.23296 17.75390  1.000 18.37905 ? 4   TYR E CA  1 
ATOM   3081 C C   . TYR C 3 4   ? -3.36482  -37.32616 18.41148  1.000 19.31785 ? 4   TYR E C   1 
ATOM   3082 O O   . TYR C 3 4   ? -3.34673  -37.46294 19.64112  1.000 19.55696 ? 4   TYR E O   1 
ATOM   3083 C CB  . TYR C 3 4   ? -1.05725  -36.39206 18.13057  1.000 19.46825 ? 4   TYR E CB  1 
ATOM   3084 C CG  . TYR C 3 4   ? -0.10334  -35.72840 17.16926  1.000 21.95006 ? 4   TYR E CG  1 
ATOM   3085 C CD1 . TYR C 3 4   ? 0.21492   -36.32679 15.96308  1.000 21.44934 ? 4   TYR E CD1 1 
ATOM   3086 C CD2 . TYR C 3 4   ? 0.47730   -34.50145 17.46926  1.000 25.39024 ? 4   TYR E CD2 1 
ATOM   3087 C CE1 . TYR C 3 4   ? 1.07674   -35.72389 15.07781  1.000 24.53273 ? 4   TYR E CE1 1 
ATOM   3088 C CE2 . TYR C 3 4   ? 1.35342   -33.88626 16.58437  1.000 23.86684 ? 4   TYR E CE2 1 
ATOM   3089 C CZ  . TYR C 3 4   ? 1.65042   -34.50578 15.39257  1.000 27.20092 ? 4   TYR E CZ  1 
ATOM   3090 O OH  . TYR C 3 4   ? 2.52287   -33.90997 14.49999  1.000 34.52534 ? 4   TYR E OH  1 
ATOM   3091 N N   . LEU C 3 5   ? -4.05797  -38.12667 17.59398  1.000 16.49017 ? 5   LEU E N   1 
ATOM   3092 C CA  . LEU C 3 5   ? -5.01669  -39.13433 18.05392  1.000 17.67841 ? 5   LEU E CA  1 
ATOM   3093 C C   . LEU C 3 5   ? -4.57224  -40.51410 17.59279  1.000 20.76121 ? 5   LEU E C   1 
ATOM   3094 O O   . LEU C 3 5   ? -4.75359  -40.87027 16.42073  1.000 16.48949 ? 5   LEU E O   1 
ATOM   3095 C CB  . LEU C 3 5   ? -6.43006  -38.86931 17.53108  1.000 16.40178 ? 5   LEU E CB  1 
ATOM   3096 C CG  . LEU C 3 5   ? -7.23162  -37.66753 18.01212  1.000 21.52179 ? 5   LEU E CG  1 
ATOM   3097 C CD1 . LEU C 3 5   ? -7.05144  -37.42413 19.50810  1.000 27.45625 ? 5   LEU E CD1 1 
ATOM   3098 C CD2 . LEU C 3 5   ? -7.09107  -36.41890 17.14855  1.000 20.97793 ? 5   LEU E CD2 1 
ATOM   3099 N N   . TYR C 3 6   ? -4.04496  -41.30187 18.52922  1.000 18.45654 ? 6   TYR E N   1 
ATOM   3100 C CA  . TYR C 3 6   ? -3.55340  -42.64105 18.26237  1.000 18.14505 ? 6   TYR E CA  1 
ATOM   3101 C C   . TYR C 3 6   ? -4.20433  -43.68969 19.15461  1.000 18.50504 ? 6   TYR E C   1 
ATOM   3102 O O   . TYR C 3 6   ? -3.88665  -44.87577 19.02867  1.000 22.15293 ? 6   TYR E O   1 
ATOM   3103 C CB  . TYR C 3 6   ? -2.03916  -42.68600 18.47646  1.000 17.75181 ? 6   TYR E CB  1 
ATOM   3104 C CG  . TYR C 3 6   ? -1.24699  -41.90019 17.47009  1.000 18.27911 ? 6   TYR E CG  1 
ATOM   3105 C CD1 . TYR C 3 6   ? -1.06467  -42.37892 16.17114  1.000 18.29935 ? 6   TYR E CD1 1 
ATOM   3106 C CD2 . TYR C 3 6   ? -0.69099  -40.68008 17.80635  1.000 18.02683 ? 6   TYR E CD2 1 
ATOM   3107 C CE1 . TYR C 3 6   ? -0.30982  -41.67541 15.23805  1.000 20.35141 ? 6   TYR E CE1 1 
ATOM   3108 C CE2 . TYR C 3 6   ? 0.06803   -39.95488 16.87230  1.000 20.77757 ? 6   TYR E CE2 1 
ATOM   3109 C CZ  . TYR C 3 6   ? 0.24251   -40.46000 15.59101  1.000 20.86633 ? 6   TYR E CZ  1 
ATOM   3110 O OH  . TYR C 3 6   ? 0.97692   -39.74762 14.66679  1.000 21.55469 ? 6   TYR E OH  1 
ATOM   3111 N N   . ARG C 3 7   ? -5.10814  -43.29412 20.03920  1.000 19.82295 ? 7   ARG E N   1 
ATOM   3112 C CA  . ARG C 3 7   ? -5.58254  -44.20045 21.06848  1.000 19.93550 ? 7   ARG E CA  1 
ATOM   3113 C C   . ARG C 3 7   ? -6.70118  -45.09010 20.52370  1.000 18.76359 ? 7   ARG E C   1 
ATOM   3114 O O   . ARG C 3 7   ? -7.65555  -44.60582 19.91546  1.000 18.37603 ? 7   ARG E O   1 
ATOM   3115 C CB  . ARG C 3 7   ? -6.03882  -43.38109 22.27840  1.000 22.29859 ? 7   ARG E CB  1 
ATOM   3116 C CG  . ARG C 3 7   ? -6.34605  -44.20751 23.48945  1.000 24.93969 ? 7   ARG E CG  1 
ATOM   3117 C CD  . ARG C 3 7   ? -5.17422  -45.11233 23.84775  1.000 27.11117 ? 7   ARG E CD  1 
ATOM   3118 N NE  . ARG C 3 7   ? -3.97260  -44.41203 24.29363  1.000 26.95476 ? 7   ARG E NE  1 
ATOM   3119 C CZ  . ARG C 3 7   ? -3.12551  -44.92113 25.18016  1.000 32.82632 ? 7   ARG E CZ  1 
ATOM   3120 N NH1 . ARG C 3 7   ? -3.30725  -46.13148 25.68625  1.000 32.56934 ? 7   ARG E NH1 1 
ATOM   3121 N NH2 . ARG C 3 7   ? -2.07432  -44.20014 25.57026  1.000 30.64574 ? 7   ARG E NH2 1 
ATOM   3122 N N   . LEU C 3 8   ? -6.57172  -46.39301 20.71951  1.000 16.91592 ? 8   LEU E N   1 
ATOM   3123 C CA  . LEU C 3 8   ? -7.56046  -47.33746 20.22818  1.000 20.46392 ? 8   LEU E CA  1 
ATOM   3124 C C   . LEU C 3 8   ? -8.67316  -47.53778 21.26451  1.000 22.56020 ? 8   LEU E C   1 
ATOM   3125 O O   . LEU C 3 8   ? -8.48967  -47.31609 22.46322  1.000 24.26819 ? 8   LEU E O   1 
ATOM   3126 C CB  . LEU C 3 8   ? -6.89446  -48.66815 19.89724  1.000 19.81512 ? 8   LEU E CB  1 
ATOM   3127 C CG  . LEU C 3 8   ? -5.82516  -48.56065 18.80364  1.000 21.48354 ? 8   LEU E CG  1 
ATOM   3128 C CD1 . LEU C 3 8   ? -5.24162  -49.90717 18.44669  1.000 22.29545 ? 8   LEU E CD1 1 
ATOM   3129 C CD2 . LEU C 3 8   ? -6.42362  -47.89731 17.57181  1.000 17.11845 ? 8   LEU E CD2 1 
ATOM   3130 N N   . LEU C 3 9   ? -9.83956  -47.97003 20.79281  1.000 24.02202 ? 9   LEU E N   1 
ATOM   3131 C CA  . LEU C 3 9   ? -10.91532 -48.26439 21.74193  1.000 24.72019 ? 9   LEU E CA  1 
ATOM   3132 C C   . LEU C 3 9   ? -10.69238 -49.59038 22.47876  1.000 26.75859 ? 9   LEU E C   1 
ATOM   3133 O O   . LEU C 3 9   ? -11.45693 -49.91594 23.40199  1.000 27.40917 ? 9   LEU E O   1 
ATOM   3134 C CB  . LEU C 3 9   ? -12.27866 -48.30826 21.06282  1.000 23.51731 ? 9   LEU E CB  1 
ATOM   3135 C CG  . LEU C 3 9   ? -12.80795 -47.03211 20.41503  1.000 24.44979 ? 9   LEU E CG  1 
ATOM   3136 C CD1 . LEU C 3 9   ? -13.99212 -47.40108 19.54245  1.000 23.70953 ? 9   LEU E CD1 1 
ATOM   3137 C CD2 . LEU C 3 9   ? -13.13018 -45.92990 21.39901  1.000 18.77575 ? 9   LEU E CD2 1 
ATOM   3138 O OXT . LEU C 3 9   ? -9.76729  -50.35767 22.17979  1.000 26.48171 ? 9   LEU E OXT 1 
HETATM 3139 O O   . HOH D 4 .   ? -3.74231  -35.32853 37.26462  1.000 36.39751 ? 301 HOH A O   1 
HETATM 3140 O O   . HOH D 4 .   ? -57.96112 -6.79549  18.15349  1.000 29.31770 ? 302 HOH A O   1 
HETATM 3141 O O   . HOH D 4 .   ? -12.76926 -37.61287 38.15758  1.000 38.04623 ? 303 HOH A O   1 
HETATM 3142 O O   . HOH D 4 .   ? -58.90021 -21.07020 9.06701   1.000 35.81976 ? 304 HOH A O   1 
HETATM 3143 O O   . HOH D 4 .   ? -20.93363 -51.62070 1.70139   1.000 36.87189 ? 305 HOH A O   1 
HETATM 3144 O O   . HOH D 4 .   ? -13.25520 -42.58068 34.60934  1.000 23.35678 ? 306 HOH A O   1 
HETATM 3145 O O   . HOH D 4 .   ? -0.15085  -27.38413 1.21132   1.000 35.52906 ? 307 HOH A O   1 
HETATM 3146 O O   . HOH D 4 .   ? -46.37254 -2.52016  19.10775  1.000 40.34100 ? 308 HOH A O   1 
HETATM 3147 O O   . HOH D 4 .   ? -23.47720 -46.15479 6.58452   1.000 34.16705 ? 309 HOH A O   1 
HETATM 3148 O O   . HOH D 4 .   ? -10.09869 -34.46462 -4.76072  1.000 32.96855 ? 310 HOH A O   1 
HETATM 3149 O O   . HOH D 4 .   ? -20.20420 -14.94839 25.35327  1.000 35.78685 ? 311 HOH A O   1 
HETATM 3150 O O   . HOH D 4 .   ? -32.18784 -3.31602  19.44978  1.000 33.21387 ? 312 HOH A O   1 
HETATM 3151 O O   . HOH D 4 .   ? -5.11072  -38.46559 21.84456  1.000 28.95596 ? 313 HOH A O   1 
HETATM 3152 O O   . HOH D 4 .   ? -34.24438 -6.12460  12.20931  1.000 30.90854 ? 314 HOH A O   1 
HETATM 3153 O O   . HOH D 4 .   ? -10.61833 -31.68700 0.13307   1.000 40.04422 ? 315 HOH A O   1 
HETATM 3154 O O   . HOH D 4 .   ? -21.78640 -42.34755 14.98071  1.000 16.58143 ? 316 HOH A O   1 
HETATM 3155 O O   . HOH D 4 .   ? -28.36900 -8.34235  23.30921  1.000 36.26725 ? 317 HOH A O   1 
HETATM 3156 O O   . HOH D 4 .   ? -24.21415 -12.15102 1.39629   1.000 32.50044 ? 318 HOH A O   1 
HETATM 3157 O O   . HOH D 4 .   ? -4.98730  -23.20757 29.82594  1.000 27.92727 ? 319 HOH A O   1 
HETATM 3158 O O   . HOH D 4 .   ? -7.99483  -42.16640 31.42918  1.000 17.73057 ? 320 HOH A O   1 
HETATM 3159 O O   . HOH D 4 .   ? -18.65597 -53.86918 8.97875   1.000 32.83309 ? 321 HOH A O   1 
HETATM 3160 O O   . HOH D 4 .   ? -20.03555 -27.84318 22.85353  1.000 34.55641 ? 322 HOH A O   1 
HETATM 3161 O O   . HOH D 4 .   ? -4.89035  -17.82104 11.40010  1.000 30.34761 ? 323 HOH A O   1 
HETATM 3162 O O   . HOH D 4 .   ? -22.39893 -47.22976 30.89358  1.000 27.09324 ? 324 HOH A O   1 
HETATM 3163 O O   . HOH D 4 .   ? -1.01620  -34.23251 -2.32442  1.000 18.89593 ? 325 HOH A O   1 
HETATM 3164 O O   . HOH D 4 .   ? -6.07006  -27.50196 11.77714  1.000 19.96563 ? 326 HOH A O   1 
HETATM 3165 O O   . HOH D 4 .   ? 1.16643   -29.67155 16.14886  1.000 30.82298 ? 327 HOH A O   1 
HETATM 3166 O O   . HOH D 4 .   ? -17.65061 -50.77076 13.02485  1.000 22.50628 ? 328 HOH A O   1 
HETATM 3167 O O   . HOH D 4 .   ? -15.00233 -50.11916 4.38326   1.000 30.00274 ? 329 HOH A O   1 
HETATM 3168 O O   . HOH D 4 .   ? -4.46177  -37.05375 14.99386  1.000 20.54924 ? 330 HOH A O   1 
HETATM 3169 O O   . HOH D 4 .   ? -14.34810 -48.07135 34.99222  1.000 31.39606 ? 331 HOH A O   1 
HETATM 3170 O O   . HOH D 4 .   ? -8.22713  -32.94478 -3.63731  1.000 26.85278 ? 332 HOH A O   1 
HETATM 3171 O O   . HOH D 4 .   ? -6.23014  -20.70401 29.96561  1.000 34.87162 ? 333 HOH A O   1 
HETATM 3172 O O   . HOH D 4 .   ? -17.00010 -16.04483 15.67614  1.000 21.16723 ? 334 HOH A O   1 
HETATM 3173 O O   . HOH D 4 .   ? -18.52088 -53.72251 31.86896  1.000 36.84075 ? 335 HOH A O   1 
HETATM 3174 O O   . HOH D 4 .   ? -22.35348 -55.08039 10.62681  1.000 35.81005 ? 336 HOH A O   1 
HETATM 3175 O O   . HOH D 4 .   ? 1.22739   -26.90171 21.36115  1.000 32.68810 ? 337 HOH A O   1 
HETATM 3176 O O   . HOH D 4 .   ? -29.82054 -27.12431 12.35955  1.000 33.48343 ? 338 HOH A O   1 
HETATM 3177 O O   . HOH D 4 .   ? -49.47074 -21.49447 8.96165   1.000 27.67595 ? 339 HOH A O   1 
HETATM 3178 O O   . HOH D 4 .   ? -19.84451 -28.93202 20.69212  1.000 28.87965 ? 340 HOH A O   1 
HETATM 3179 O O   . HOH D 4 .   ? -23.89660 -19.56735 18.03091  1.000 23.84203 ? 341 HOH A O   1 
HETATM 3180 O O   . HOH D 4 .   ? -50.67615 -13.84543 1.29597   1.000 33.30199 ? 342 HOH A O   1 
HETATM 3181 O O   . HOH D 4 .   ? -42.06020 -25.73965 7.87099   1.000 37.65277 ? 343 HOH A O   1 
HETATM 3182 O O   . HOH D 4 .   ? -6.26705  -24.40812 32.47102  1.000 30.19031 ? 344 HOH A O   1 
HETATM 3183 O O   . HOH D 4 .   ? -24.96706 -51.62706 6.36077   1.000 37.20087 ? 345 HOH A O   1 
HETATM 3184 O O   . HOH D 4 .   ? -41.98405 -25.59509 15.56799  1.000 30.91236 ? 346 HOH A O   1 
HETATM 3185 O O   . HOH D 4 .   ? -7.84257  -35.55307 0.55548   1.000 18.08075 ? 347 HOH A O   1 
HETATM 3186 O O   . HOH D 4 .   ? -14.64571 -10.83630 20.80292  1.000 37.04479 ? 348 HOH A O   1 
HETATM 3187 O O   . HOH D 4 .   ? -14.75985 -53.00439 1.52468   1.000 43.34117 ? 349 HOH A O   1 
HETATM 3188 O O   . HOH D 4 .   ? -26.80282 -14.29315 19.79575  1.000 21.51001 ? 350 HOH A O   1 
HETATM 3189 O O   . HOH D 4 .   ? -18.95213 -19.75045 20.55078  1.000 29.21788 ? 351 HOH A O   1 
HETATM 3190 O O   . HOH D 4 .   ? -15.80038 -34.43827 26.13317  1.000 18.35785 ? 352 HOH A O   1 
HETATM 3191 O O   . HOH D 4 .   ? 0.49391   -27.13862 13.10975  1.000 26.57365 ? 353 HOH A O   1 
HETATM 3192 O O   . HOH D 4 .   ? -48.74025 -8.95158  14.98327  1.000 16.37283 ? 354 HOH A O   1 
HETATM 3193 O O   . HOH D 4 .   ? -9.81504  -25.34492 0.07776   1.000 25.60114 ? 355 HOH A O   1 
HETATM 3194 O O   . HOH D 4 .   ? -14.16759 -40.65060 13.10528  1.000 18.67414 ? 356 HOH A O   1 
HETATM 3195 O O   . HOH D 4 .   ? -0.18440  -37.22239 25.15482  0.50  25.07341 ? 357 HOH A O   1 
HETATM 3196 O O   . HOH D 4 .   ? -7.51939  -41.26102 34.06061  1.000 23.98903 ? 358 HOH A O   1 
HETATM 3197 O O   . HOH D 4 .   ? -11.04637 -43.33814 2.06606   1.000 30.76923 ? 359 HOH A O   1 
HETATM 3198 O O   . HOH D 4 .   ? -1.10855  -33.95671 29.13029  1.000 17.74557 ? 360 HOH A O   1 
HETATM 3199 O O   . HOH D 4 .   ? 3.49998   -21.79363 9.32438   1.000 38.72003 ? 361 HOH A O   1 
HETATM 3200 O O   . HOH D 4 .   ? -4.15993  -37.94225 38.05692  1.000 34.42798 ? 362 HOH A O   1 
HETATM 3201 O O   . HOH D 4 .   ? -0.747    -36.106   2.136     1.000 29.66537 ? 363 HOH A O   1 
HETATM 3202 O O   . HOH D 4 .   ? -18.07172 -26.24964 3.73236   1.000 19.84543 ? 364 HOH A O   1 
HETATM 3203 O O   . HOH D 4 .   ? -37.45255 -13.98054 22.08281  1.000 23.32909 ? 365 HOH A O   1 
HETATM 3204 O O   . HOH D 4 .   ? -50.72855 -3.07704  14.88683  1.000 34.83257 ? 366 HOH A O   1 
HETATM 3205 O O   . HOH D 4 .   ? -19.154   -44.530   32.770    1.000 24.89506 ? 367 HOH A O   1 
HETATM 3206 O O   . HOH D 4 .   ? -24.40586 -47.17587 19.49677  1.000 28.04237 ? 368 HOH A O   1 
HETATM 3207 O O   . HOH D 4 .   ? -56.61604 -14.83102 19.51718  1.000 27.51788 ? 369 HOH A O   1 
HETATM 3208 O O   . HOH D 4 .   ? -29.72584 -20.68400 16.65480  1.000 18.71811 ? 370 HOH A O   1 
HETATM 3209 O O   . HOH D 4 .   ? -55.79973 -17.23170 27.32536  1.000 27.14013 ? 371 HOH A O   1 
HETATM 3210 O O   . HOH D 4 .   ? -11.41080 -43.55045 9.35611   1.000 21.96205 ? 372 HOH A O   1 
HETATM 3211 O O   . HOH D 4 .   ? -18.76794 -33.48554 32.47001  1.000 27.94064 ? 373 HOH A O   1 
HETATM 3212 O O   . HOH D 4 .   ? -23.90262 -19.06627 5.98011   1.000 20.02681 ? 374 HOH A O   1 
HETATM 3213 O O   . HOH D 4 .   ? -1.98592  -33.78320 24.91880  1.000 18.28014 ? 375 HOH A O   1 
HETATM 3214 O O   . HOH D 4 .   ? -20.47512 -19.09612 9.17354   1.000 27.93839 ? 376 HOH A O   1 
HETATM 3215 O O   . HOH D 4 .   ? 6.94124   -28.27795 6.69551   1.000 34.11549 ? 377 HOH A O   1 
HETATM 3216 O O   . HOH D 4 .   ? -35.50396 -9.12290  7.18977   1.000 24.64905 ? 378 HOH A O   1 
HETATM 3217 O O   . HOH D 4 .   ? -22.82285 -46.57739 21.83066  1.000 32.71618 ? 379 HOH A O   1 
HETATM 3218 O O   . HOH D 4 .   ? -42.60316 -6.64141  6.67662   1.000 24.84627 ? 380 HOH A O   1 
HETATM 3219 O O   . HOH D 4 .   ? -14.10467 -14.01054 30.52376  1.000 41.34291 ? 381 HOH A O   1 
HETATM 3220 O O   . HOH D 4 .   ? -13.64102 -56.37584 13.27883  1.000 29.29587 ? 382 HOH A O   1 
HETATM 3221 O O   . HOH D 4 .   ? -8.91633  -33.18373 1.91431   1.000 21.62227 ? 383 HOH A O   1 
HETATM 3222 O O   . HOH D 4 .   ? -17.44839 -24.20687 17.41429  1.000 21.13231 ? 384 HOH A O   1 
HETATM 3223 O O   . HOH D 4 .   ? -16.00560 -31.80622 29.26477  1.000 28.86619 ? 385 HOH A O   1 
HETATM 3224 O O   . HOH D 4 .   ? -27.49310 -39.42167 19.81065  1.000 33.19470 ? 386 HOH A O   1 
HETATM 3225 O O   . HOH D 4 .   ? -17.49313 -51.34948 10.23485  1.000 18.45384 ? 387 HOH A O   1 
HETATM 3226 O O   . HOH D 4 .   ? -36.62397 -26.97528 10.89640  1.000 22.22418 ? 388 HOH A O   1 
HETATM 3227 O O   . HOH D 4 .   ? -15.66409 -49.19955 32.77804  1.000 29.02704 ? 389 HOH A O   1 
HETATM 3228 O O   . HOH D 4 .   ? -34.98955 -23.88348 17.32541  1.000 25.99164 ? 390 HOH A O   1 
HETATM 3229 O O   . HOH D 4 .   ? -27.65214 -12.89015 3.79501   1.000 26.17584 ? 391 HOH A O   1 
HETATM 3230 O O   . HOH D 4 .   ? -52.32684 -16.49728 1.35227   1.000 33.10989 ? 392 HOH A O   1 
HETATM 3231 O O   . HOH D 4 .   ? -49.87645 -19.27305 5.41698   1.000 32.02307 ? 393 HOH A O   1 
HETATM 3232 O O   . HOH D 4 .   ? -30.53178 -16.38676 22.15332  1.000 24.86298 ? 394 HOH A O   1 
HETATM 3233 O O   . HOH D 4 .   ? -52.90910 -17.83596 17.96106  1.000 29.72312 ? 395 HOH A O   1 
HETATM 3234 O O   . HOH D 4 .   ? -2.46275  -28.02598 2.80764   1.000 24.89734 ? 396 HOH A O   1 
HETATM 3235 O O   . HOH D 4 .   ? -48.42480 -9.49890  22.54537  1.000 24.07415 ? 397 HOH A O   1 
HETATM 3236 O O   . HOH D 4 .   ? -25.19305 -51.78411 8.93533   1.000 36.30219 ? 398 HOH A O   1 
HETATM 3237 O O   . HOH D 4 .   ? -17.39791 -41.87287 35.58614  1.000 33.41901 ? 399 HOH A O   1 
HETATM 3238 O O   . HOH D 4 .   ? -24.78524 -50.65221 16.70459  1.000 27.17479 ? 400 HOH A O   1 
HETATM 3239 O O   . HOH D 4 .   ? -61.51634 -8.72667  15.25437  1.000 30.44457 ? 401 HOH A O   1 
HETATM 3240 O O   . HOH D 4 .   ? -7.52319  -43.32635 35.51574  1.000 27.53519 ? 402 HOH A O   1 
HETATM 3241 O O   . HOH D 4 .   ? 1.91307   -34.12285 11.61947  1.000 28.68011 ? 403 HOH A O   1 
HETATM 3242 O O   . HOH D 4 .   ? -13.24948 -29.24557 30.89115  1.000 24.52654 ? 404 HOH A O   1 
HETATM 3243 O O   . HOH D 4 .   ? -29.60154 -14.24598 4.96460   1.000 21.72133 ? 405 HOH A O   1 
HETATM 3244 O O   . HOH D 4 .   ? -20.08620 -39.61095 23.99173  1.000 16.03560 ? 406 HOH A O   1 
HETATM 3245 O O   . HOH D 4 .   ? -32.16769 -24.20222 15.55303  1.000 20.23924 ? 407 HOH A O   1 
HETATM 3246 O O   . HOH D 4 .   ? -8.68231  -21.18001 33.33940  1.000 35.79072 ? 408 HOH A O   1 
HETATM 3247 O O   . HOH D 4 .   ? -16.19265 -18.48227 34.46287  1.000 33.32061 ? 409 HOH A O   1 
HETATM 3248 O O   . HOH D 4 .   ? -18.28813 -54.59679 29.79015  1.000 32.25066 ? 410 HOH A O   1 
HETATM 3249 O O   . HOH D 4 .   ? -24.27883 -45.84420 11.12180  1.000 25.00608 ? 411 HOH A O   1 
HETATM 3250 O O   . HOH D 4 .   ? -45.60200 -22.03995 9.36488   1.000 33.47988 ? 412 HOH A O   1 
HETATM 3251 O O   . HOH D 4 .   ? -43.12436 -18.71019 21.06368  1.000 26.40087 ? 413 HOH A O   1 
HETATM 3252 O O   . HOH D 4 .   ? -54.55879 -26.17315 18.20975  1.000 42.61382 ? 414 HOH A O   1 
HETATM 3253 O O   . HOH D 4 .   ? -12.41979 -50.29874 9.25728   1.000 28.92004 ? 415 HOH A O   1 
HETATM 3254 O O   . HOH D 4 .   ? -11.22208 -12.20516 8.75038   1.000 36.05587 ? 416 HOH A O   1 
HETATM 3255 O O   . HOH D 4 .   ? -11.19987 -41.76752 35.97068  1.000 30.54867 ? 417 HOH A O   1 
HETATM 3256 O O   . HOH D 4 .   ? -18.69609 -21.37707 7.88897   1.000 24.26261 ? 418 HOH A O   1 
HETATM 3257 O O   . HOH D 4 .   ? -24.08407 -46.80200 9.10083   1.000 34.67660 ? 419 HOH A O   1 
HETATM 3258 O O   . HOH D 4 .   ? -55.64827 -6.50164  11.66702  1.000 31.21112 ? 420 HOH A O   1 
HETATM 3259 O O   . HOH D 4 .   ? -15.91034 -21.77724 2.87088   1.000 34.19758 ? 421 HOH A O   1 
HETATM 3260 O O   . HOH D 4 .   ? -8.98117  -10.14978 10.64392  1.000 35.23071 ? 422 HOH A O   1 
HETATM 3261 O O   . HOH D 4 .   ? -20.59416 -40.78903 26.33222  1.000 17.69917 ? 423 HOH A O   1 
HETATM 3262 O O   . HOH D 4 .   ? -10.85630 -51.46277 7.61455   1.000 35.28997 ? 424 HOH A O   1 
HETATM 3263 O O   . HOH D 4 .   ? -36.13512 -19.47176 19.01085  1.000 23.65078 ? 425 HOH A O   1 
HETATM 3264 O O   . HOH D 4 .   ? -2.55408  -43.72484 13.25188  1.000 26.10318 ? 426 HOH A O   1 
HETATM 3265 O O   . HOH D 4 .   ? -2.93855  -48.32391 35.92519  1.000 40.21686 ? 427 HOH A O   1 
HETATM 3266 O O   . HOH D 4 .   ? -26.62117 -40.16730 22.56725  1.000 26.54559 ? 428 HOH A O   1 
HETATM 3267 O O   . HOH D 4 .   ? -65.76633 -20.01487 11.46376  1.000 44.13704 ? 429 HOH A O   1 
HETATM 3268 O O   . HOH D 4 .   ? -18.60997 -20.54715 23.74467  1.000 26.42024 ? 430 HOH A O   1 
HETATM 3269 O O   . HOH D 4 .   ? -25.44010 -9.51662  7.22486   1.000 36.09694 ? 431 HOH A O   1 
HETATM 3270 O O   . HOH D 4 .   ? -19.01404 -11.17303 11.31432  1.000 28.45710 ? 432 HOH A O   1 
HETATM 3271 O O   . HOH D 4 .   ? -2.95065  -21.93233 27.59114  1.000 34.21390 ? 433 HOH A O   1 
HETATM 3272 O O   . HOH D 4 .   ? -15.80386 -19.71999 6.47302   1.000 31.16952 ? 434 HOH A O   1 
HETATM 3273 O O   . HOH D 4 .   ? -38.73579 -20.01728 21.48747  1.000 31.70896 ? 435 HOH A O   1 
HETATM 3274 O O   . HOH D 4 .   ? -56.37412 -17.10388 19.69239  1.000 30.78513 ? 436 HOH A O   1 
HETATM 3275 O O   . HOH D 4 .   ? -30.40947 -30.79914 13.91785  1.000 31.40671 ? 437 HOH A O   1 
HETATM 3276 O O   . HOH D 4 .   ? -15.59737 -42.76688 36.38755  1.000 34.07469 ? 438 HOH A O   1 
HETATM 3277 O O   . HOH D 4 .   ? -44.71869 -2.83437  20.49259  1.000 35.85098 ? 439 HOH A O   1 
HETATM 3278 O O   . HOH D 4 .   ? 0.25301   -28.21339 17.48654  1.000 38.64171 ? 440 HOH A O   1 
HETATM 3279 O O   . HOH D 4 .   ? -2.06086  -27.84190 0.30980   1.000 31.92621 ? 441 HOH A O   1 
HETATM 3280 O O   . HOH D 4 .   ? -42.15388 -5.78805  9.02306   1.000 28.64520 ? 442 HOH A O   1 
HETATM 3281 O O   . HOH D 4 .   ? -11.61211 -24.32754 -0.75491  1.000 35.91292 ? 443 HOH A O   1 
HETATM 3282 O O   . HOH D 4 .   ? -3.57874  -26.68980 1.61313   1.000 28.98973 ? 444 HOH A O   1 
HETATM 3283 O O   . HOH D 4 .   ? -59.69433 -5.22224  17.09887  1.000 38.43216 ? 445 HOH A O   1 
HETATM 3284 O O   . HOH D 4 .   ? -0.97729  -41.25203 8.73246   1.000 28.74736 ? 446 HOH A O   1 
HETATM 3285 O O   . HOH D 4 .   ? -20.71456 -26.28214 20.46688  1.000 25.67134 ? 447 HOH A O   1 
HETATM 3286 O O   . HOH D 4 .   ? -43.560   -5.494    11.308    1.000 35.44715 ? 448 HOH A O   1 
HETATM 3287 O O   . HOH D 4 .   ? -7.31878  -53.02505 21.81985  1.000 40.33308 ? 449 HOH A O   1 
HETATM 3288 O O   . HOH D 4 .   ? -53.105   -6.952    26.474    1.000 36.71413 ? 450 HOH A O   1 
HETATM 3289 O O   . HOH D 4 .   ? -15.65454 -14.81821 5.74200   1.000 31.98018 ? 451 HOH A O   1 
HETATM 3290 O O   . HOH D 4 .   ? -19.65369 -13.07978 9.85299   1.000 30.97846 ? 452 HOH A O   1 
HETATM 3291 O O   . HOH D 4 .   ? -20.13598 -46.82809 32.91273  1.000 26.46326 ? 453 HOH A O   1 
HETATM 3292 O O   . HOH D 4 .   ? -2.57932  -22.97081 30.85822  1.000 38.87608 ? 454 HOH A O   1 
HETATM 3293 O O   . HOH D 4 .   ? -19.56578 -25.83441 16.94843  1.000 23.21429 ? 455 HOH A O   1 
HETATM 3294 O O   . HOH D 4 .   ? -27.90140 -22.28845 16.54299  1.000 23.63700 ? 456 HOH A O   1 
HETATM 3295 O O   . HOH D 4 .   ? -13.79446 -54.62832 3.08640   1.000 39.06138 ? 457 HOH A O   1 
HETATM 3296 O O   . HOH D 4 .   ? -1.54316  -42.79393 6.77701   1.000 32.65586 ? 458 HOH A O   1 
HETATM 3297 O O   . HOH D 4 .   ? -20.64684 -17.94769 19.88430  1.000 36.31033 ? 459 HOH A O   1 
HETATM 3298 O O   . HOH D 4 .   ? -15.02422 -51.95648 9.89765   1.000 26.56737 ? 460 HOH A O   1 
HETATM 3299 O O   . HOH D 4 .   ? -19.55039 -42.26630 2.83701   1.000 30.49741 ? 461 HOH A O   1 
HETATM 3300 O O   . HOH D 4 .   ? -2.94015  -50.64519 35.31391  1.000 37.41636 ? 462 HOH A O   1 
HETATM 3301 O O   . HOH D 4 .   ? -9.46449  -43.52114 36.94675  1.000 31.97523 ? 463 HOH A O   1 
HETATM 3302 O O   . HOH D 4 .   ? -17.41565 -13.15070 5.73765   1.000 30.53010 ? 464 HOH A O   1 
HETATM 3303 O O   . HOH D 4 .   ? -26.54931 -10.38836 5.21664   1.000 35.63109 ? 465 HOH A O   1 
HETATM 3304 O O   . HOH D 4 .   ? -21.07557 -27.55641 18.60516  1.000 26.91503 ? 466 HOH A O   1 
HETATM 3305 O O   . HOH D 4 .   ? -22.25885 -21.05681 7.16002   1.000 27.26100 ? 467 HOH A O   1 
HETATM 3306 O O   . HOH D 4 .   ? -12.69207 -34.35967 -3.78708  1.000 36.44823 ? 468 HOH A O   1 
HETATM 3307 O O   . HOH D 4 .   ? -26.16531 -23.57253 12.91824  1.000 34.75768 ? 469 HOH A O   1 
HETATM 3308 O O   . HOH D 4 .   ? -18.11863 -18.78907 7.01110   1.000 32.36842 ? 470 HOH A O   1 
HETATM 3309 O O   . HOH D 4 .   ? -17.39668 -16.23393 7.23727   1.000 34.84766 ? 471 HOH A O   1 
HETATM 3310 O O   . HOH D 4 .   ? -14.41118 -12.51520 32.46665  1.000 44.00264 ? 472 HOH A O   1 
HETATM 3311 O O   . HOH D 4 .   ? -25.10948 -50.83866 3.08933   1.000 45.96762 ? 473 HOH A O   1 
HETATM 3312 O O   . HOH D 4 .   ? -25.985   -50.334   19.814    1.000 47.54527 ? 474 HOH A O   1 
HETATM 3313 O O   . HOH D 4 .   ? -5.01687  -50.01449 36.96878  1.000 43.72703 ? 475 HOH A O   1 
HETATM 3314 O O   . HOH E 4 .   ? -27.33850 -44.04337 12.06579  1.000 32.29020 ? 101 HOH B O   1 
HETATM 3315 O O   . HOH E 4 .   ? -24.77146 -27.87403 16.35722  1.000 44.28023 ? 102 HOH B O   1 
HETATM 3316 O O   . HOH E 4 .   ? -38.50160 -19.17516 -10.00708 1.000 30.17981 ? 103 HOH B O   1 
HETATM 3317 O O   . HOH E 4 .   ? -43.44591 -32.12910 -3.66996  1.000 26.37349 ? 104 HOH B O   1 
HETATM 3318 O O   . HOH E 4 .   ? -40.26295 -13.41856 3.35012   1.000 21.29547 ? 105 HOH B O   1 
HETATM 3319 O O   . HOH E 4 .   ? -29.29169 -43.16328 3.38952   1.000 23.86711 ? 106 HOH B O   1 
HETATM 3320 O O   . HOH E 4 .   ? -35.32735 -19.21527 -12.66761 1.000 32.50845 ? 107 HOH B O   1 
HETATM 3321 O O   . HOH E 4 .   ? -40.76226 -39.35584 1.16630   1.000 23.23507 ? 108 HOH B O   1 
HETATM 3322 O O   . HOH E 4 .   ? -31.75878 -21.42892 -13.08113 1.000 29.23502 ? 109 HOH B O   1 
HETATM 3323 O O   . HOH E 4 .   ? -39.42058 -22.87966 1.05794   1.000 24.22448 ? 110 HOH B O   1 
HETATM 3324 O O   . HOH E 4 .   ? -37.52203 -36.55110 6.17549   1.000 29.97333 ? 111 HOH B O   1 
HETATM 3325 O O   . HOH E 4 .   ? -19.09019 -25.77623 -0.38610  1.000 32.75382 ? 112 HOH B O   1 
HETATM 3326 O O   . HOH E 4 .   ? -25.54220 -20.67512 -0.45086  1.000 20.70040 ? 113 HOH B O   1 
HETATM 3327 O O   . HOH E 4 .   ? -22.14437 -29.21997 6.52458   1.000 13.33903 ? 114 HOH B O   1 
HETATM 3328 O O   . HOH E 4 .   ? -46.45475 -39.97142 -2.74599  1.000 35.07527 ? 115 HOH B O   1 
HETATM 3329 O O   . HOH E 4 .   ? -35.05830 -45.05658 0.47775   1.000 28.85492 ? 116 HOH B O   1 
HETATM 3330 O O   . HOH E 4 .   ? -40.46967 -39.22199 -4.68092  1.000 22.09482 ? 117 HOH B O   1 
HETATM 3331 O O   . HOH E 4 .   ? -35.43525 -41.83291 -0.41965  1.000 22.54464 ? 118 HOH B O   1 
HETATM 3332 O O   . HOH E 4 .   ? -36.70574 -45.40935 -1.64770  1.000 25.43824 ? 119 HOH B O   1 
HETATM 3333 O O   . HOH E 4 .   ? -21.98443 -27.68889 14.41585  1.000 24.62448 ? 120 HOH B O   1 
HETATM 3334 O O   . HOH E 4 .   ? -22.97299 -42.25254 8.58364   1.000 20.85972 ? 121 HOH B O   1 
HETATM 3335 O O   . HOH E 4 .   ? -47.20736 -24.68423 -11.88742 1.000 43.65437 ? 122 HOH B O   1 
HETATM 3336 O O   . HOH E 4 .   ? -34.42758 -19.25150 -15.92026 1.000 34.37054 ? 123 HOH B O   1 
HETATM 3337 O O   . HOH E 4 .   ? -28.27280 -31.74397 12.78638  1.000 17.83987 ? 124 HOH B O   1 
HETATM 3338 O O   . HOH E 4 .   ? -28.65882 -31.40172 -8.35687  1.000 22.06691 ? 125 HOH B O   1 
HETATM 3339 O O   . HOH E 4 .   ? -44.64780 -39.27534 -5.54975  1.000 35.36451 ? 126 HOH B O   1 
HETATM 3340 O O   . HOH E 4 .   ? -26.13861 -32.38390 -5.43794  1.000 28.70424 ? 127 HOH B O   1 
HETATM 3341 O O   . HOH E 4 .   ? -22.28493 -14.94925 -11.15990 1.000 42.61531 ? 128 HOH B O   1 
HETATM 3342 O O   . HOH E 4 .   ? -23.69930 -31.67240 -4.82025  1.000 30.75933 ? 129 HOH B O   1 
HETATM 3343 O O   . HOH E 4 .   ? -31.90256 -27.87959 -15.27068 1.000 40.51887 ? 130 HOH B O   1 
HETATM 3344 O O   . HOH E 4 .   ? -31.88166 -36.86627 -4.74259  1.000 22.15407 ? 131 HOH B O   1 
HETATM 3345 O O   . HOH E 4 .   ? -33.37731 -12.73446 -6.09504  1.000 25.80233 ? 132 HOH B O   1 
HETATM 3346 O O   . HOH E 4 .   ? -34.95498 -35.83036 12.73134  1.000 31.84093 ? 133 HOH B O   1 
HETATM 3347 O O   . HOH E 4 .   ? -18.84016 -24.17956 -15.99681 1.000 49.94829 ? 134 HOH B O   1 
HETATM 3348 O O   . HOH E 4 .   ? -31.90491 -33.14468 19.49992  1.000 41.37102 ? 135 HOH B O   1 
HETATM 3349 O O   . HOH E 4 .   ? -41.01545 -19.41708 -7.60179  1.000 34.00220 ? 136 HOH B O   1 
HETATM 3350 O O   . HOH E 4 .   ? -29.20040 -31.90351 -16.57117 1.000 43.16358 ? 137 HOH B O   1 
HETATM 3351 O O   . HOH E 4 .   ? -34.82460 -43.82531 -3.64445  1.000 19.96855 ? 138 HOH B O   1 
HETATM 3352 O O   . HOH E 4 .   ? -37.47795 -15.97197 -0.96354  1.000 32.22122 ? 139 HOH B O   1 
HETATM 3353 O O   . HOH E 4 .   ? -34.87216 -17.24306 2.45126   1.000 23.13809 ? 140 HOH B O   1 
HETATM 3354 O O   . HOH E 4 .   ? -24.59039 -13.40202 -1.45969  1.000 35.22407 ? 141 HOH B O   1 
HETATM 3355 O O   . HOH E 4 .   ? -39.73124 -29.87120 4.88528   1.000 33.90921 ? 142 HOH B O   1 
HETATM 3356 O O   . HOH E 4 .   ? -21.50403 -40.26051 4.02284   1.000 29.49652 ? 143 HOH B O   1 
HETATM 3357 O O   . HOH E 4 .   ? -17.58303 -34.60771 9.77888   1.000 15.66188 ? 144 HOH B O   1 
HETATM 3358 O O   . HOH E 4 .   ? -40.66138 -24.74911 1.08636   1.000 30.34488 ? 145 HOH B O   1 
HETATM 3359 O O   . HOH E 4 .   ? -42.88133 -14.46145 -9.22751  1.000 34.52149 ? 146 HOH B O   1 
HETATM 3360 O O   . HOH E 4 .   ? -29.878   -33.478   -15.204   1.000 36.40010 ? 147 HOH B O   1 
HETATM 3361 O O   . HOH E 4 .   ? -15.83303 -32.69938 2.07513   1.000 30.18328 ? 148 HOH B O   1 
HETATM 3362 O O   . HOH E 4 .   ? -36.38400 -39.49157 12.69783  1.000 34.07433 ? 149 HOH B O   1 
HETATM 3363 O O   . HOH E 4 .   ? -38.53874 -28.30613 -9.95212  1.000 27.99057 ? 150 HOH B O   1 
HETATM 3364 O O   . HOH E 4 .   ? -31.21707 -49.68878 6.94175   1.000 39.88167 ? 151 HOH B O   1 
HETATM 3365 O O   . HOH E 4 .   ? -44.06881 -23.26211 -3.51546  1.000 31.28540 ? 152 HOH B O   1 
HETATM 3366 O O   . HOH E 4 .   ? -40.20978 -9.93689  -4.25568  1.000 27.46220 ? 153 HOH B O   1 
HETATM 3367 O O   . HOH E 4 .   ? -42.33204 -28.05380 -8.57456  1.000 40.01909 ? 154 HOH B O   1 
HETATM 3368 O O   . HOH E 4 .   ? -43.55671 -18.89275 -3.58504  1.000 34.76258 ? 155 HOH B O   1 
HETATM 3369 O O   . HOH E 4 .   ? -37.40454 -37.07596 -9.35378  1.000 28.48262 ? 156 HOH B O   1 
HETATM 3370 O O   . HOH E 4 .   ? -25.90680 -26.34381 -13.60107 1.000 36.09147 ? 157 HOH B O   1 
HETATM 3371 O O   . HOH E 4 .   ? -29.03121 -9.74623  -11.27770 1.000 38.82096 ? 158 HOH B O   1 
HETATM 3372 O O   . HOH E 4 .   ? -25.92812 -35.62338 -3.16877  1.000 24.52062 ? 159 HOH B O   1 
HETATM 3373 O O   . HOH E 4 .   ? -26.22495 -24.74228 10.98825  1.000 33.44776 ? 160 HOH B O   1 
HETATM 3374 O O   . HOH E 4 .   ? -30.54582 -19.01751 -13.33370 1.000 31.64580 ? 161 HOH B O   1 
HETATM 3375 O O   . HOH E 4 .   ? -40.43153 -22.42601 -7.12248  1.000 34.65941 ? 162 HOH B O   1 
HETATM 3376 O O   . HOH E 4 .   ? -45.81420 -24.27101 1.04931   1.000 40.55097 ? 163 HOH B O   1 
HETATM 3377 O O   . HOH E 4 .   ? -23.62119 -43.70727 5.94711   1.000 27.06751 ? 164 HOH B O   1 
HETATM 3378 O O   . HOH E 4 .   ? -38.51420 -24.00013 5.97546   1.000 27.95673 ? 165 HOH B O   1 
HETATM 3379 O O   . HOH E 4 .   ? -39.48617 -38.61744 12.00998  1.000 36.40881 ? 166 HOH B O   1 
HETATM 3380 O O   . HOH E 4 .   ? -19.16221 -29.05437 -3.59607  1.000 28.16588 ? 167 HOH B O   1 
HETATM 3381 O O   . HOH E 4 .   ? -40.12308 -10.41370 -8.07903  1.000 33.93637 ? 168 HOH B O   1 
HETATM 3382 O O   . HOH E 4 .   ? -17.98922 -33.85134 2.87507   1.000 26.51210 ? 169 HOH B O   1 
HETATM 3383 O O   . HOH E 4 .   ? -21.77718 -30.56413 17.43273  1.000 24.04389 ? 170 HOH B O   1 
HETATM 3384 O O   . HOH E 4 .   ? -38.76240 -31.63595 6.74161   1.000 26.30317 ? 171 HOH B O   1 
HETATM 3385 O O   . HOH E 4 .   ? -28.48486 -28.00365 -15.14396 1.000 32.29973 ? 172 HOH B O   1 
HETATM 3386 O O   . HOH E 4 .   ? -25.80098 -34.91529 -5.39325  1.000 31.93169 ? 173 HOH B O   1 
HETATM 3387 O O   . HOH E 4 .   ? -23.90555 -24.63403 -15.17249 1.000 45.16560 ? 174 HOH B O   1 
HETATM 3388 O O   . HOH E 4 .   ? -27.24858 -42.83262 -1.04747  1.000 36.64774 ? 175 HOH B O   1 
HETATM 3389 O O   . HOH E 4 .   ? -38.31225 -35.49795 -11.42730 1.000 34.09853 ? 176 HOH B O   1 
HETATM 3390 O O   . HOH E 4 .   ? -38.37535 -29.56787 7.86444   1.000 34.71884 ? 177 HOH B O   1 
HETATM 3391 O O   . HOH E 4 .   ? -39.95438 -27.26758 4.17914   1.000 28.05630 ? 178 HOH B O   1 
HETATM 3392 O O   . HOH E 4 .   ? -21.04699 -18.89765 -2.12320  1.000 33.32400 ? 179 HOH B O   1 
HETATM 3393 O O   . HOH E 4 .   ? -40.02395 -32.18325 5.06250   1.000 32.42893 ? 180 HOH B O   1 
HETATM 3394 O O   . HOH E 4 .   ? -21.10539 -34.30846 19.91458  1.000 27.72506 ? 181 HOH B O   1 
HETATM 3395 O O   . HOH E 4 .   ? -32.75237 -17.82512 -15.35510 1.000 37.79667 ? 182 HOH B O   1 
HETATM 3396 O O   . HOH E 4 .   ? -41.91173 -41.29890 1.96189   1.000 27.95738 ? 183 HOH B O   1 
HETATM 3397 O O   . HOH E 4 .   ? -24.79316 -41.64724 -2.41435  1.000 43.56658 ? 184 HOH B O   1 
HETATM 3398 O O   . HOH E 4 .   ? -42.97045 -37.47912 -5.00766  1.000 31.78710 ? 185 HOH B O   1 
HETATM 3399 O O   . HOH E 4 .   ? -27.041   -39.046   -9.802    1.000 38.99847 ? 186 HOH B O   1 
HETATM 3400 O O   . HOH E 4 .   ? -42.84710 -20.02667 -6.32643  1.000 37.24029 ? 187 HOH B O   1 
HETATM 3401 O O   . HOH E 4 .   ? -43.60335 -33.69395 0.54668   1.000 35.82165 ? 188 HOH B O   1 
HETATM 3402 O O   . HOH E 4 .   ? -20.58806 -16.54087 -3.22365  1.000 44.87543 ? 189 HOH B O   1 
HETATM 3403 O O   . HOH E 4 .   ? -40.59824 -29.05819 -9.25030  1.000 35.84306 ? 190 HOH B O   1 
HETATM 3404 O O   . HOH E 4 .   ? -38.43132 -27.45439 8.56242   1.000 23.35326 ? 191 HOH B O   1 
HETATM 3405 O O   . HOH E 4 .   ? -20.48487 -31.88327 19.08591  1.000 25.91345 ? 192 HOH B O   1 
HETATM 3406 O O   . HOH E 4 .   ? -21.64534 -27.61614 16.52257  1.000 35.73454 ? 193 HOH B O   1 
HETATM 3407 O O   . HOH E 4 .   ? -28.01481 -18.81183 -13.51749 1.000 40.34668 ? 194 HOH B O   1 
HETATM 3408 O O   . HOH E 4 .   ? -25.60196 -25.61607 14.32958  1.000 35.55869 ? 195 HOH B O   1 
HETATM 3409 O O   . HOH E 4 .   ? -40.52333 -33.94114 -10.48301 1.000 28.31343 ? 196 HOH B O   1 
HETATM 3410 O O   . HOH E 4 .   ? -39.96508 -25.66922 6.83024   1.000 31.26539 ? 197 HOH B O   1 
HETATM 3411 O O   . HOH E 4 .   ? -27.78260 -8.84277  -12.99831 1.000 45.36866 ? 198 HOH B O   1 
HETATM 3412 O O   . HOH E 4 .   ? -37.230   -2.875    -2.655    1.000 40.81673 ? 199 HOH B O   1 
HETATM 3413 O O   . HOH F 4 .   ? -1.65823  -33.06060 19.58474  1.000 24.98370 ? 101 HOH E O   1 
HETATM 3414 O O   . HOH F 4 .   ? 1.52950   -40.66303 12.35676  1.000 28.87780 ? 102 HOH E O   1 
HETATM 3415 O O   . HOH F 4 .   ? -8.46137  -42.15682 19.84389  1.000 24.27088 ? 103 HOH E O   1 
HETATM 3416 O O   . HOH F 4 .   ? -8.37879  -34.20115 21.42995  1.000 25.39355 ? 104 HOH E O   1 
HETATM 3417 O O   . HOH F 4 .   ? -2.40614  -46.37790 17.12878  1.000 24.03245 ? 105 HOH E O   1 
HETATM 3418 O O   . HOH F 4 .   ? -6.49201  -40.84457 20.47149  1.000 25.85825 ? 106 HOH E O   1 
HETATM 3419 O O   . HOH F 4 .   ? -1.78160  -37.44563 22.02523  1.000 25.85192 ? 107 HOH E O   1 
HETATM 3420 O O   . HOH F 4 .   ? -4.43181  -47.68459 22.15330  1.000 29.72035 ? 108 HOH E O   1 
HETATM 3421 O O   . HOH F 4 .   ? -3.18899  -40.31879 21.14356  1.000 25.80654 ? 109 HOH E O   1 
HETATM 3422 O O   . HOH F 4 .   ? -1.53825  -34.75630 22.63743  1.000 19.56546 ? 110 HOH E O   1 
HETATM 3423 O O   . HOH F 4 .   ? -6.31535  -48.73590 24.27472  1.000 31.52889 ? 111 HOH E O   1 
HETATM 3424 O O   . HOH F 4 .   ? -4.91158  -51.25603 22.85329  1.000 34.37049 ? 112 HOH E O   1 
# 
