data_8YZA
# 
_entry.id   8YZA 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YZA         pdb_00008yza 10.2210/pdb8yza/pdb 
WWPDB D_1300046608 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YZA 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-06 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 zhengyu.zhang@whu.edu.cn Zhengyu Zhang ? 'principal investigator/group leader' 0000-0001-5035-1229 
4 quxd19@sjtu.edu.cn       Xudong  Qu    ? 'principal investigator/group leader' 0000-0002-3301-8536 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhang, Z.Y.' 1 ? 
'Qu, X.D.'    2 ? 
'Duan, B.R.'  3 ? 
'Wei, G.Z.'   4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Proc.Natl.Acad.Sci.USA 
_citation.journal_id_ASTM           PNASA6 
_citation.journal_id_CSD            0040 
_citation.journal_id_ISSN           1091-6490 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            121 
_citation.language                  ? 
_citation.page_first                e2412890121 
_citation.page_last                 e2412890121 
_citation.title                     
'A nucleobase-driven P450 peroxidase system enables regio- and stereo-specific formation of C&#9472;C and C&#9472;N bonds.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1073/pnas.2412890121 
_citation.pdbx_database_id_PubMed   39508763 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wei, G.'    1  0000-0002-5967-3168 
primary 'Duan, B.'   2  0000-0002-1043-502X 
primary 'Zhou, T.P.' 3  ?                   
primary 'Tian, W.'   4  ?                   
primary 'Sun, C.'    5  ?                   
primary 'Lin, Z.'    6  0009-0005-2240-449X 
primary 'Deng, Z.'   7  ?                   
primary 'Wang, B.'   8  0000-0002-3353-9411 
primary 'Zhang, Z.'  9  ?                   
primary 'Qu, X.'     10 0000-0002-3301-8536 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man PtmB                                                         45299.418 1   ? ? ? 
;Sequence reference for Kitasatospora medicidica KCTC 9733 strain (TAX ID 1449347) is not available in UniProt at  the time of biocuration. Kitasatospora medicidica KCTC 9733: NCBI RefSeq assembly is GCF_000744225.1 and GenBank assembly is GCA_000744225.1.
;
2 non-polymer syn '(3S,6S)-3,6-bis[(1H-indol-3-yl)methyl]piperazine-2,5-dione' 372.420   1   ? ? ? ? 
3 non-polymer syn GUANINE                                                      151.126   1   ? ? ? ? 
4 non-polymer syn 'PROTOPORPHYRIN IX CONTAINING FE'                            616.487   1   ? ? ? ? 
5 water       nat water                                                        18.015    343 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MTTTAQRDPVLPGTAHHPPLPDFPLSRRGDILPAEAERLRAEQPVARVRTMTGDEAWLVSSYELAKQVLEDDRFSLKDTA
NPGVPRQYALTIPPEVVNNMGNINSAGLRNAVMKTLSPQADRELGGWLEAQAHQLLDRLIEQGPPADLRDGFTEPYSAAL
HCRLLGIPTDDWRRLMSGIDVAFITSPRTFEGSAVNWYKDLGYMVDRLNADPEPTEGLLGRFAELRRSPDVSDQVSDELL
ATVALSLFGAGAVSTSAFLQHAIIALAQQPELADRLRAEPAVIGRAVDELLRYNLSIGDALPRIALADVRLGEVEIRAGE
LVLVLIEGANYDPAVFPHPERIDFDRESNPHLAFGGGQHFCPASALGRTHAEIALTALVEKLPALRLALPVEQLAWRPGF
IKRLPERLPVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MTTTAQRDPVLPGTAHHPPLPDFPLSRRGDILPAEAERLRAEQPVARVRTMTGDEAWLVSSYELAKQVLEDDRFSLKDTA
NPGVPRQYALTIPPEVVNNMGNINSAGLRNAVMKTLSPQADRELGGWLEAQAHQLLDRLIEQGPPADLRDGFTEPYSAAL
HCRLLGIPTDDWRRLMSGIDVAFITSPRTFEGSAVNWYKDLGYMVDRLNADPEPTEGLLGRFAELRRSPDVSDQVSDELL
ATVALSLFGAGAVSTSAFLQHAIIALAQQPELADRLRAEPAVIGRAVDELLRYNLSIGDALPRIALADVRLGEVEIRAGE
LVLVLIEGANYDPAVFPHPERIDFDRESNPHLAFGGGQHFCPASALGRTHAEIALTALVEKLPALRLALPVEQLAWRPGF
IKRLPERLPVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '(3S,6S)-3,6-bis[(1H-indol-3-yl)methyl]piperazine-2,5-dione' UYM 
3 GUANINE                                                      GUN 
4 'PROTOPORPHYRIN IX CONTAINING FE'                            HEM 
5 water                                                        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   THR n 
1 3   THR n 
1 4   THR n 
1 5   ALA n 
1 6   GLN n 
1 7   ARG n 
1 8   ASP n 
1 9   PRO n 
1 10  VAL n 
1 11  LEU n 
1 12  PRO n 
1 13  GLY n 
1 14  THR n 
1 15  ALA n 
1 16  HIS n 
1 17  HIS n 
1 18  PRO n 
1 19  PRO n 
1 20  LEU n 
1 21  PRO n 
1 22  ASP n 
1 23  PHE n 
1 24  PRO n 
1 25  LEU n 
1 26  SER n 
1 27  ARG n 
1 28  ARG n 
1 29  GLY n 
1 30  ASP n 
1 31  ILE n 
1 32  LEU n 
1 33  PRO n 
1 34  ALA n 
1 35  GLU n 
1 36  ALA n 
1 37  GLU n 
1 38  ARG n 
1 39  LEU n 
1 40  ARG n 
1 41  ALA n 
1 42  GLU n 
1 43  GLN n 
1 44  PRO n 
1 45  VAL n 
1 46  ALA n 
1 47  ARG n 
1 48  VAL n 
1 49  ARG n 
1 50  THR n 
1 51  MET n 
1 52  THR n 
1 53  GLY n 
1 54  ASP n 
1 55  GLU n 
1 56  ALA n 
1 57  TRP n 
1 58  LEU n 
1 59  VAL n 
1 60  SER n 
1 61  SER n 
1 62  TYR n 
1 63  GLU n 
1 64  LEU n 
1 65  ALA n 
1 66  LYS n 
1 67  GLN n 
1 68  VAL n 
1 69  LEU n 
1 70  GLU n 
1 71  ASP n 
1 72  ASP n 
1 73  ARG n 
1 74  PHE n 
1 75  SER n 
1 76  LEU n 
1 77  LYS n 
1 78  ASP n 
1 79  THR n 
1 80  ALA n 
1 81  ASN n 
1 82  PRO n 
1 83  GLY n 
1 84  VAL n 
1 85  PRO n 
1 86  ARG n 
1 87  GLN n 
1 88  TYR n 
1 89  ALA n 
1 90  LEU n 
1 91  THR n 
1 92  ILE n 
1 93  PRO n 
1 94  PRO n 
1 95  GLU n 
1 96  VAL n 
1 97  VAL n 
1 98  ASN n 
1 99  ASN n 
1 100 MET n 
1 101 GLY n 
1 102 ASN n 
1 103 ILE n 
1 104 ASN n 
1 105 SER n 
1 106 ALA n 
1 107 GLY n 
1 108 LEU n 
1 109 ARG n 
1 110 ASN n 
1 111 ALA n 
1 112 VAL n 
1 113 MET n 
1 114 LYS n 
1 115 THR n 
1 116 LEU n 
1 117 SER n 
1 118 PRO n 
1 119 GLN n 
1 120 ALA n 
1 121 ASP n 
1 122 ARG n 
1 123 GLU n 
1 124 LEU n 
1 125 GLY n 
1 126 GLY n 
1 127 TRP n 
1 128 LEU n 
1 129 GLU n 
1 130 ALA n 
1 131 GLN n 
1 132 ALA n 
1 133 HIS n 
1 134 GLN n 
1 135 LEU n 
1 136 LEU n 
1 137 ASP n 
1 138 ARG n 
1 139 LEU n 
1 140 ILE n 
1 141 GLU n 
1 142 GLN n 
1 143 GLY n 
1 144 PRO n 
1 145 PRO n 
1 146 ALA n 
1 147 ASP n 
1 148 LEU n 
1 149 ARG n 
1 150 ASP n 
1 151 GLY n 
1 152 PHE n 
1 153 THR n 
1 154 GLU n 
1 155 PRO n 
1 156 TYR n 
1 157 SER n 
1 158 ALA n 
1 159 ALA n 
1 160 LEU n 
1 161 HIS n 
1 162 CYS n 
1 163 ARG n 
1 164 LEU n 
1 165 LEU n 
1 166 GLY n 
1 167 ILE n 
1 168 PRO n 
1 169 THR n 
1 170 ASP n 
1 171 ASP n 
1 172 TRP n 
1 173 ARG n 
1 174 ARG n 
1 175 LEU n 
1 176 MET n 
1 177 SER n 
1 178 GLY n 
1 179 ILE n 
1 180 ASP n 
1 181 VAL n 
1 182 ALA n 
1 183 PHE n 
1 184 ILE n 
1 185 THR n 
1 186 SER n 
1 187 PRO n 
1 188 ARG n 
1 189 THR n 
1 190 PHE n 
1 191 GLU n 
1 192 GLY n 
1 193 SER n 
1 194 ALA n 
1 195 VAL n 
1 196 ASN n 
1 197 TRP n 
1 198 TYR n 
1 199 LYS n 
1 200 ASP n 
1 201 LEU n 
1 202 GLY n 
1 203 TYR n 
1 204 MET n 
1 205 VAL n 
1 206 ASP n 
1 207 ARG n 
1 208 LEU n 
1 209 ASN n 
1 210 ALA n 
1 211 ASP n 
1 212 PRO n 
1 213 GLU n 
1 214 PRO n 
1 215 THR n 
1 216 GLU n 
1 217 GLY n 
1 218 LEU n 
1 219 LEU n 
1 220 GLY n 
1 221 ARG n 
1 222 PHE n 
1 223 ALA n 
1 224 GLU n 
1 225 LEU n 
1 226 ARG n 
1 227 ARG n 
1 228 SER n 
1 229 PRO n 
1 230 ASP n 
1 231 VAL n 
1 232 SER n 
1 233 ASP n 
1 234 GLN n 
1 235 VAL n 
1 236 SER n 
1 237 ASP n 
1 238 GLU n 
1 239 LEU n 
1 240 LEU n 
1 241 ALA n 
1 242 THR n 
1 243 VAL n 
1 244 ALA n 
1 245 LEU n 
1 246 SER n 
1 247 LEU n 
1 248 PHE n 
1 249 GLY n 
1 250 ALA n 
1 251 GLY n 
1 252 ALA n 
1 253 VAL n 
1 254 SER n 
1 255 THR n 
1 256 SER n 
1 257 ALA n 
1 258 PHE n 
1 259 LEU n 
1 260 GLN n 
1 261 HIS n 
1 262 ALA n 
1 263 ILE n 
1 264 ILE n 
1 265 ALA n 
1 266 LEU n 
1 267 ALA n 
1 268 GLN n 
1 269 GLN n 
1 270 PRO n 
1 271 GLU n 
1 272 LEU n 
1 273 ALA n 
1 274 ASP n 
1 275 ARG n 
1 276 LEU n 
1 277 ARG n 
1 278 ALA n 
1 279 GLU n 
1 280 PRO n 
1 281 ALA n 
1 282 VAL n 
1 283 ILE n 
1 284 GLY n 
1 285 ARG n 
1 286 ALA n 
1 287 VAL n 
1 288 ASP n 
1 289 GLU n 
1 290 LEU n 
1 291 LEU n 
1 292 ARG n 
1 293 TYR n 
1 294 ASN n 
1 295 LEU n 
1 296 SER n 
1 297 ILE n 
1 298 GLY n 
1 299 ASP n 
1 300 ALA n 
1 301 LEU n 
1 302 PRO n 
1 303 ARG n 
1 304 ILE n 
1 305 ALA n 
1 306 LEU n 
1 307 ALA n 
1 308 ASP n 
1 309 VAL n 
1 310 ARG n 
1 311 LEU n 
1 312 GLY n 
1 313 GLU n 
1 314 VAL n 
1 315 GLU n 
1 316 ILE n 
1 317 ARG n 
1 318 ALA n 
1 319 GLY n 
1 320 GLU n 
1 321 LEU n 
1 322 VAL n 
1 323 LEU n 
1 324 VAL n 
1 325 LEU n 
1 326 ILE n 
1 327 GLU n 
1 328 GLY n 
1 329 ALA n 
1 330 ASN n 
1 331 TYR n 
1 332 ASP n 
1 333 PRO n 
1 334 ALA n 
1 335 VAL n 
1 336 PHE n 
1 337 PRO n 
1 338 HIS n 
1 339 PRO n 
1 340 GLU n 
1 341 ARG n 
1 342 ILE n 
1 343 ASP n 
1 344 PHE n 
1 345 ASP n 
1 346 ARG n 
1 347 GLU n 
1 348 SER n 
1 349 ASN n 
1 350 PRO n 
1 351 HIS n 
1 352 LEU n 
1 353 ALA n 
1 354 PHE n 
1 355 GLY n 
1 356 GLY n 
1 357 GLY n 
1 358 GLN n 
1 359 HIS n 
1 360 PHE n 
1 361 CYS n 
1 362 PRO n 
1 363 ALA n 
1 364 SER n 
1 365 ALA n 
1 366 LEU n 
1 367 GLY n 
1 368 ARG n 
1 369 THR n 
1 370 HIS n 
1 371 ALA n 
1 372 GLU n 
1 373 ILE n 
1 374 ALA n 
1 375 LEU n 
1 376 THR n 
1 377 ALA n 
1 378 LEU n 
1 379 VAL n 
1 380 GLU n 
1 381 LYS n 
1 382 LEU n 
1 383 PRO n 
1 384 ALA n 
1 385 LEU n 
1 386 ARG n 
1 387 LEU n 
1 388 ALA n 
1 389 LEU n 
1 390 PRO n 
1 391 VAL n 
1 392 GLU n 
1 393 GLN n 
1 394 LEU n 
1 395 ALA n 
1 396 TRP n 
1 397 ARG n 
1 398 PRO n 
1 399 GLY n 
1 400 PHE n 
1 401 ILE n 
1 402 LYS n 
1 403 ARG n 
1 404 LEU n 
1 405 PRO n 
1 406 GLU n 
1 407 ARG n 
1 408 LEU n 
1 409 PRO n 
1 410 VAL n 
1 411 LEU n 
1 412 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   412 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Kitasatospora mediocidica KCTC 9733' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1449347 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                      ?    'C3 H7 N O2'       89.093  
ARG 'L-peptide linking' y ARGININE                                                     ?    'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                   ?    'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                              ?    'C4 H7 N O4'       133.103 
CYS 'L-peptide linking' y CYSTEINE                                                     ?    'C3 H7 N O2 S'     121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                    ?    'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                              ?    'C5 H9 N O4'       147.129 
GLY 'peptide linking'   y GLYCINE                                                      ?    'C2 H5 N O2'       75.067  
GUN non-polymer         . GUANINE                                                      ?    'C5 H5 N5 O'       151.126 
HEM non-polymer         . 'PROTOPORPHYRIN IX CONTAINING FE'                            HEME 'C34 H32 Fe N4 O4' 616.487 
HIS 'L-peptide linking' y HISTIDINE                                                    ?    'C6 H10 N3 O2 1'   156.162 
HOH non-polymer         . WATER                                                        ?    'H2 O'             18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                   ?    'C6 H13 N O2'      131.173 
LEU 'L-peptide linking' y LEUCINE                                                      ?    'C6 H13 N O2'      131.173 
LYS 'L-peptide linking' y LYSINE                                                       ?    'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking' y METHIONINE                                                   ?    'C5 H11 N O2 S'    149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                ?    'C9 H11 N O2'      165.189 
PRO 'L-peptide linking' y PROLINE                                                      ?    'C5 H9 N O2'       115.130 
SER 'L-peptide linking' y SERINE                                                       ?    'C3 H7 N O3'       105.093 
THR 'L-peptide linking' y THREONINE                                                    ?    'C4 H9 N O3'       119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                   ?    'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking' y TYROSINE                                                     ?    'C9 H11 N O3'      181.189 
UYM non-polymer         . '(3S,6S)-3,6-bis[(1H-indol-3-yl)methyl]piperazine-2,5-dione' ?    'C22 H20 N4 O2'    372.420 
VAL 'L-peptide linking' y VALINE                                                       ?    'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   THR 2   2   ?   ?   ?   A . n 
A 1 3   THR 3   3   ?   ?   ?   A . n 
A 1 4   THR 4   4   ?   ?   ?   A . n 
A 1 5   ALA 5   5   ?   ?   ?   A . n 
A 1 6   GLN 6   6   ?   ?   ?   A . n 
A 1 7   ARG 7   7   ?   ?   ?   A . n 
A 1 8   ASP 8   8   ?   ?   ?   A . n 
A 1 9   PRO 9   9   ?   ?   ?   A . n 
A 1 10  VAL 10  10  ?   ?   ?   A . n 
A 1 11  LEU 11  11  ?   ?   ?   A . n 
A 1 12  PRO 12  12  ?   ?   ?   A . n 
A 1 13  GLY 13  13  ?   ?   ?   A . n 
A 1 14  THR 14  14  ?   ?   ?   A . n 
A 1 15  ALA 15  15  ?   ?   ?   A . n 
A 1 16  HIS 16  16  ?   ?   ?   A . n 
A 1 17  HIS 17  17  ?   ?   ?   A . n 
A 1 18  PRO 18  18  18  PRO PRO A . n 
A 1 19  PRO 19  19  19  PRO PRO A . n 
A 1 20  LEU 20  20  20  LEU LEU A . n 
A 1 21  PRO 21  21  21  PRO PRO A . n 
A 1 22  ASP 22  22  22  ASP ASP A . n 
A 1 23  PHE 23  23  23  PHE PHE A . n 
A 1 24  PRO 24  24  24  PRO PRO A . n 
A 1 25  LEU 25  25  25  LEU LEU A . n 
A 1 26  SER 26  26  26  SER SER A . n 
A 1 27  ARG 27  27  27  ARG ARG A . n 
A 1 28  ARG 28  28  28  ARG ARG A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  ASP 30  30  30  ASP ASP A . n 
A 1 31  ILE 31  31  31  ILE ILE A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  PRO 33  33  33  PRO PRO A . n 
A 1 34  ALA 34  34  34  ALA ALA A . n 
A 1 35  GLU 35  35  35  GLU GLU A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  GLU 37  37  37  GLU GLU A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  LEU 39  39  39  LEU LEU A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  ALA 41  41  41  ALA ALA A . n 
A 1 42  GLU 42  42  42  GLU GLU A . n 
A 1 43  GLN 43  43  43  GLN GLN A . n 
A 1 44  PRO 44  44  44  PRO PRO A . n 
A 1 45  VAL 45  45  45  VAL VAL A . n 
A 1 46  ALA 46  46  46  ALA ALA A . n 
A 1 47  ARG 47  47  47  ARG ARG A . n 
A 1 48  VAL 48  48  48  VAL VAL A . n 
A 1 49  ARG 49  49  49  ARG ARG A . n 
A 1 50  THR 50  50  50  THR THR A . n 
A 1 51  MET 51  51  51  MET MET A . n 
A 1 52  THR 52  52  52  THR THR A . n 
A 1 53  GLY 53  53  53  GLY GLY A . n 
A 1 54  ASP 54  54  54  ASP ASP A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ALA 56  56  56  ALA ALA A . n 
A 1 57  TRP 57  57  57  TRP TRP A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  VAL 59  59  59  VAL VAL A . n 
A 1 60  SER 60  60  60  SER SER A . n 
A 1 61  SER 61  61  61  SER SER A . n 
A 1 62  TYR 62  62  62  TYR TYR A . n 
A 1 63  GLU 63  63  63  GLU GLU A . n 
A 1 64  LEU 64  64  64  LEU LEU A . n 
A 1 65  ALA 65  65  65  ALA ALA A . n 
A 1 66  LYS 66  66  66  LYS LYS A . n 
A 1 67  GLN 67  67  67  GLN GLN A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  LEU 69  69  69  LEU LEU A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  ASP 71  71  71  ASP ASP A . n 
A 1 72  ASP 72  72  72  ASP ASP A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  PHE 74  74  74  PHE PHE A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  LEU 76  76  76  LEU LEU A . n 
A 1 77  LYS 77  77  77  LYS LYS A . n 
A 1 78  ASP 78  78  78  ASP ASP A . n 
A 1 79  THR 79  79  79  THR THR A . n 
A 1 80  ALA 80  80  80  ALA ALA A . n 
A 1 81  ASN 81  81  81  ASN ASN A . n 
A 1 82  PRO 82  82  82  PRO PRO A . n 
A 1 83  GLY 83  83  83  GLY GLY A . n 
A 1 84  VAL 84  84  84  VAL VAL A . n 
A 1 85  PRO 85  85  85  PRO PRO A . n 
A 1 86  ARG 86  86  86  ARG ARG A . n 
A 1 87  GLN 87  87  87  GLN GLN A . n 
A 1 88  TYR 88  88  88  TYR TYR A . n 
A 1 89  ALA 89  89  89  ALA ALA A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  ILE 92  92  92  ILE ILE A . n 
A 1 93  PRO 93  93  93  PRO PRO A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  GLU 95  95  95  GLU GLU A . n 
A 1 96  VAL 96  96  96  VAL VAL A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  ASN 98  98  98  ASN ASN A . n 
A 1 99  ASN 99  99  99  ASN ASN A . n 
A 1 100 MET 100 100 100 MET MET A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 ASN 102 102 102 ASN ASN A . n 
A 1 103 ILE 103 103 103 ILE ILE A . n 
A 1 104 ASN 104 104 104 ASN ASN A . n 
A 1 105 SER 105 105 105 SER SER A . n 
A 1 106 ALA 106 106 106 ALA ALA A . n 
A 1 107 GLY 107 107 107 GLY GLY A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 ARG 109 109 109 ARG ARG A . n 
A 1 110 ASN 110 110 110 ASN ASN A . n 
A 1 111 ALA 111 111 111 ALA ALA A . n 
A 1 112 VAL 112 112 112 VAL VAL A . n 
A 1 113 MET 113 113 113 MET MET A . n 
A 1 114 LYS 114 114 114 LYS LYS A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 LEU 116 116 116 LEU LEU A . n 
A 1 117 SER 117 117 117 SER SER A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 GLN 119 119 119 GLN GLN A . n 
A 1 120 ALA 120 120 120 ALA ALA A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 ARG 122 122 122 ARG ARG A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 LEU 124 124 124 LEU LEU A . n 
A 1 125 GLY 125 125 125 GLY GLY A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 TRP 127 127 127 TRP TRP A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 GLU 129 129 129 GLU GLU A . n 
A 1 130 ALA 130 130 130 ALA ALA A . n 
A 1 131 GLN 131 131 131 GLN GLN A . n 
A 1 132 ALA 132 132 132 ALA ALA A . n 
A 1 133 HIS 133 133 133 HIS HIS A . n 
A 1 134 GLN 134 134 134 GLN GLN A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 LEU 136 136 136 LEU LEU A . n 
A 1 137 ASP 137 137 137 ASP ASP A . n 
A 1 138 ARG 138 138 138 ARG ARG A . n 
A 1 139 LEU 139 139 139 LEU LEU A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 GLU 141 141 141 GLU GLU A . n 
A 1 142 GLN 142 142 142 GLN GLN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 PRO 144 144 144 PRO PRO A . n 
A 1 145 PRO 145 145 145 PRO PRO A . n 
A 1 146 ALA 146 146 146 ALA ALA A . n 
A 1 147 ASP 147 147 147 ASP ASP A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 ARG 149 149 149 ARG ARG A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 GLY 151 151 151 GLY GLY A . n 
A 1 152 PHE 152 152 152 PHE PHE A . n 
A 1 153 THR 153 153 153 THR THR A . n 
A 1 154 GLU 154 154 154 GLU GLU A . n 
A 1 155 PRO 155 155 155 PRO PRO A . n 
A 1 156 TYR 156 156 156 TYR TYR A . n 
A 1 157 SER 157 157 157 SER SER A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 LEU 160 160 160 LEU LEU A . n 
A 1 161 HIS 161 161 161 HIS HIS A . n 
A 1 162 CYS 162 162 162 CYS CYS A . n 
A 1 163 ARG 163 163 163 ARG ARG A . n 
A 1 164 LEU 164 164 164 LEU LEU A . n 
A 1 165 LEU 165 165 165 LEU LEU A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 ILE 167 167 167 ILE ILE A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 ASP 170 170 170 ASP ASP A . n 
A 1 171 ASP 171 171 171 ASP ASP A . n 
A 1 172 TRP 172 172 172 TRP TRP A . n 
A 1 173 ARG 173 173 173 ARG ARG A . n 
A 1 174 ARG 174 174 174 ARG ARG A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 MET 176 176 176 MET MET A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 GLY 178 178 178 GLY GLY A . n 
A 1 179 ILE 179 179 179 ILE ILE A . n 
A 1 180 ASP 180 180 180 ASP ASP A . n 
A 1 181 VAL 181 181 181 VAL VAL A . n 
A 1 182 ALA 182 182 182 ALA ALA A . n 
A 1 183 PHE 183 183 183 PHE PHE A . n 
A 1 184 ILE 184 184 184 ILE ILE A . n 
A 1 185 THR 185 185 185 THR THR A . n 
A 1 186 SER 186 186 186 SER SER A . n 
A 1 187 PRO 187 187 187 PRO PRO A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 THR 189 189 189 THR THR A . n 
A 1 190 PHE 190 190 190 PHE PHE A . n 
A 1 191 GLU 191 191 191 GLU GLU A . n 
A 1 192 GLY 192 192 192 GLY GLY A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 VAL 195 195 195 VAL VAL A . n 
A 1 196 ASN 196 196 196 ASN ASN A . n 
A 1 197 TRP 197 197 197 TRP TRP A . n 
A 1 198 TYR 198 198 198 TYR TYR A . n 
A 1 199 LYS 199 199 199 LYS LYS A . n 
A 1 200 ASP 200 200 200 ASP ASP A . n 
A 1 201 LEU 201 201 201 LEU LEU A . n 
A 1 202 GLY 202 202 202 GLY GLY A . n 
A 1 203 TYR 203 203 203 TYR TYR A . n 
A 1 204 MET 204 204 204 MET MET A . n 
A 1 205 VAL 205 205 205 VAL VAL A . n 
A 1 206 ASP 206 206 206 ASP ASP A . n 
A 1 207 ARG 207 207 207 ARG ARG A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 ASN 209 209 209 ASN ASN A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ASP 211 211 211 ASP ASP A . n 
A 1 212 PRO 212 212 212 PRO PRO A . n 
A 1 213 GLU 213 213 213 GLU GLU A . n 
A 1 214 PRO 214 214 214 PRO PRO A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 GLU 216 216 216 GLU GLU A . n 
A 1 217 GLY 217 217 217 GLY GLY A . n 
A 1 218 LEU 218 218 218 LEU LEU A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 GLY 220 220 220 GLY GLY A . n 
A 1 221 ARG 221 221 221 ARG ARG A . n 
A 1 222 PHE 222 222 222 PHE PHE A . n 
A 1 223 ALA 223 223 223 ALA ALA A . n 
A 1 224 GLU 224 224 224 GLU GLU A . n 
A 1 225 LEU 225 225 225 LEU LEU A . n 
A 1 226 ARG 226 226 226 ARG ARG A . n 
A 1 227 ARG 227 227 227 ARG ARG A . n 
A 1 228 SER 228 228 228 SER SER A . n 
A 1 229 PRO 229 229 229 PRO PRO A . n 
A 1 230 ASP 230 230 ?   ?   ?   A . n 
A 1 231 VAL 231 231 ?   ?   ?   A . n 
A 1 232 SER 232 232 ?   ?   ?   A . n 
A 1 233 ASP 233 233 ?   ?   ?   A . n 
A 1 234 GLN 234 234 ?   ?   ?   A . n 
A 1 235 VAL 235 235 235 VAL VAL A . n 
A 1 236 SER 236 236 236 SER SER A . n 
A 1 237 ASP 237 237 237 ASP ASP A . n 
A 1 238 GLU 238 238 238 GLU GLU A . n 
A 1 239 LEU 239 239 239 LEU LEU A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 THR 242 242 242 THR THR A . n 
A 1 243 VAL 243 243 243 VAL VAL A . n 
A 1 244 ALA 244 244 244 ALA ALA A . n 
A 1 245 LEU 245 245 245 LEU LEU A . n 
A 1 246 SER 246 246 246 SER SER A . n 
A 1 247 LEU 247 247 247 LEU LEU A . n 
A 1 248 PHE 248 248 248 PHE PHE A . n 
A 1 249 GLY 249 249 249 GLY GLY A . n 
A 1 250 ALA 250 250 250 ALA ALA A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 ALA 252 252 252 ALA ALA A . n 
A 1 253 VAL 253 253 253 VAL VAL A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 THR 255 255 255 THR THR A . n 
A 1 256 SER 256 256 256 SER SER A . n 
A 1 257 ALA 257 257 257 ALA ALA A . n 
A 1 258 PHE 258 258 258 PHE PHE A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 GLN 260 260 260 GLN GLN A . n 
A 1 261 HIS 261 261 261 HIS HIS A . n 
A 1 262 ALA 262 262 262 ALA ALA A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 ILE 264 264 264 ILE ILE A . n 
A 1 265 ALA 265 265 265 ALA ALA A . n 
A 1 266 LEU 266 266 266 LEU LEU A . n 
A 1 267 ALA 267 267 267 ALA ALA A . n 
A 1 268 GLN 268 268 268 GLN GLN A . n 
A 1 269 GLN 269 269 269 GLN GLN A . n 
A 1 270 PRO 270 270 270 PRO PRO A . n 
A 1 271 GLU 271 271 271 GLU GLU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 ALA 273 273 273 ALA ALA A . n 
A 1 274 ASP 274 274 274 ASP ASP A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 LEU 276 276 276 LEU LEU A . n 
A 1 277 ARG 277 277 277 ARG ARG A . n 
A 1 278 ALA 278 278 278 ALA ALA A . n 
A 1 279 GLU 279 279 279 GLU GLU A . n 
A 1 280 PRO 280 280 280 PRO PRO A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 VAL 282 282 282 VAL VAL A . n 
A 1 283 ILE 283 283 283 ILE ILE A . n 
A 1 284 GLY 284 284 284 GLY GLY A . n 
A 1 285 ARG 285 285 285 ARG ARG A . n 
A 1 286 ALA 286 286 286 ALA ALA A . n 
A 1 287 VAL 287 287 287 VAL VAL A . n 
A 1 288 ASP 288 288 288 ASP ASP A . n 
A 1 289 GLU 289 289 289 GLU GLU A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 LEU 291 291 291 LEU LEU A . n 
A 1 292 ARG 292 292 292 ARG ARG A . n 
A 1 293 TYR 293 293 293 TYR TYR A . n 
A 1 294 ASN 294 294 294 ASN ASN A . n 
A 1 295 LEU 295 295 295 LEU LEU A . n 
A 1 296 SER 296 296 296 SER SER A . n 
A 1 297 ILE 297 297 297 ILE ILE A . n 
A 1 298 GLY 298 298 298 GLY GLY A . n 
A 1 299 ASP 299 299 299 ASP ASP A . n 
A 1 300 ALA 300 300 300 ALA ALA A . n 
A 1 301 LEU 301 301 301 LEU LEU A . n 
A 1 302 PRO 302 302 302 PRO PRO A . n 
A 1 303 ARG 303 303 303 ARG ARG A . n 
A 1 304 ILE 304 304 304 ILE ILE A . n 
A 1 305 ALA 305 305 305 ALA ALA A . n 
A 1 306 LEU 306 306 306 LEU LEU A . n 
A 1 307 ALA 307 307 307 ALA ALA A . n 
A 1 308 ASP 308 308 308 ASP ASP A . n 
A 1 309 VAL 309 309 309 VAL VAL A . n 
A 1 310 ARG 310 310 310 ARG ARG A . n 
A 1 311 LEU 311 311 311 LEU LEU A . n 
A 1 312 GLY 312 312 312 GLY GLY A . n 
A 1 313 GLU 313 313 313 GLU GLU A . n 
A 1 314 VAL 314 314 314 VAL VAL A . n 
A 1 315 GLU 315 315 315 GLU GLU A . n 
A 1 316 ILE 316 316 316 ILE ILE A . n 
A 1 317 ARG 317 317 317 ARG ARG A . n 
A 1 318 ALA 318 318 318 ALA ALA A . n 
A 1 319 GLY 319 319 319 GLY GLY A . n 
A 1 320 GLU 320 320 320 GLU GLU A . n 
A 1 321 LEU 321 321 321 LEU LEU A . n 
A 1 322 VAL 322 322 322 VAL VAL A . n 
A 1 323 LEU 323 323 323 LEU LEU A . n 
A 1 324 VAL 324 324 324 VAL VAL A . n 
A 1 325 LEU 325 325 325 LEU LEU A . n 
A 1 326 ILE 326 326 326 ILE ILE A . n 
A 1 327 GLU 327 327 327 GLU GLU A . n 
A 1 328 GLY 328 328 328 GLY GLY A . n 
A 1 329 ALA 329 329 329 ALA ALA A . n 
A 1 330 ASN 330 330 330 ASN ASN A . n 
A 1 331 TYR 331 331 331 TYR TYR A . n 
A 1 332 ASP 332 332 332 ASP ASP A . n 
A 1 333 PRO 333 333 333 PRO PRO A . n 
A 1 334 ALA 334 334 334 ALA ALA A . n 
A 1 335 VAL 335 335 335 VAL VAL A . n 
A 1 336 PHE 336 336 336 PHE PHE A . n 
A 1 337 PRO 337 337 337 PRO PRO A . n 
A 1 338 HIS 338 338 338 HIS HIS A . n 
A 1 339 PRO 339 339 339 PRO PRO A . n 
A 1 340 GLU 340 340 340 GLU GLU A . n 
A 1 341 ARG 341 341 341 ARG ARG A . n 
A 1 342 ILE 342 342 342 ILE ILE A . n 
A 1 343 ASP 343 343 343 ASP ASP A . n 
A 1 344 PHE 344 344 344 PHE PHE A . n 
A 1 345 ASP 345 345 345 ASP ASP A . n 
A 1 346 ARG 346 346 346 ARG ARG A . n 
A 1 347 GLU 347 347 347 GLU GLU A . n 
A 1 348 SER 348 348 348 SER SER A . n 
A 1 349 ASN 349 349 349 ASN ASN A . n 
A 1 350 PRO 350 350 350 PRO PRO A . n 
A 1 351 HIS 351 351 351 HIS HIS A . n 
A 1 352 LEU 352 352 352 LEU LEU A . n 
A 1 353 ALA 353 353 353 ALA ALA A . n 
A 1 354 PHE 354 354 354 PHE PHE A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 GLY 356 356 356 GLY GLY A . n 
A 1 357 GLY 357 357 357 GLY GLY A . n 
A 1 358 GLN 358 358 358 GLN GLN A . n 
A 1 359 HIS 359 359 359 HIS HIS A . n 
A 1 360 PHE 360 360 360 PHE PHE A . n 
A 1 361 CYS 361 361 361 CYS CYS A . n 
A 1 362 PRO 362 362 362 PRO PRO A . n 
A 1 363 ALA 363 363 363 ALA ALA A . n 
A 1 364 SER 364 364 364 SER SER A . n 
A 1 365 ALA 365 365 365 ALA ALA A . n 
A 1 366 LEU 366 366 366 LEU LEU A . n 
A 1 367 GLY 367 367 367 GLY GLY A . n 
A 1 368 ARG 368 368 368 ARG ARG A . n 
A 1 369 THR 369 369 369 THR THR A . n 
A 1 370 HIS 370 370 370 HIS HIS A . n 
A 1 371 ALA 371 371 371 ALA ALA A . n 
A 1 372 GLU 372 372 372 GLU GLU A . n 
A 1 373 ILE 373 373 373 ILE ILE A . n 
A 1 374 ALA 374 374 374 ALA ALA A . n 
A 1 375 LEU 375 375 375 LEU LEU A . n 
A 1 376 THR 376 376 376 THR THR A . n 
A 1 377 ALA 377 377 377 ALA ALA A . n 
A 1 378 LEU 378 378 378 LEU LEU A . n 
A 1 379 VAL 379 379 379 VAL VAL A . n 
A 1 380 GLU 380 380 380 GLU GLU A . n 
A 1 381 LYS 381 381 381 LYS LYS A . n 
A 1 382 LEU 382 382 382 LEU LEU A . n 
A 1 383 PRO 383 383 383 PRO PRO A . n 
A 1 384 ALA 384 384 384 ALA ALA A . n 
A 1 385 LEU 385 385 385 LEU LEU A . n 
A 1 386 ARG 386 386 386 ARG ARG A . n 
A 1 387 LEU 387 387 387 LEU LEU A . n 
A 1 388 ALA 388 388 388 ALA ALA A . n 
A 1 389 LEU 389 389 389 LEU LEU A . n 
A 1 390 PRO 390 390 390 PRO PRO A . n 
A 1 391 VAL 391 391 391 VAL VAL A . n 
A 1 392 GLU 392 392 392 GLU GLU A . n 
A 1 393 GLN 393 393 393 GLN GLN A . n 
A 1 394 LEU 394 394 394 LEU LEU A . n 
A 1 395 ALA 395 395 395 ALA ALA A . n 
A 1 396 TRP 396 396 396 TRP TRP A . n 
A 1 397 ARG 397 397 397 ARG ARG A . n 
A 1 398 PRO 398 398 398 PRO PRO A . n 
A 1 399 GLY 399 399 399 GLY GLY A . n 
A 1 400 PHE 400 400 400 PHE PHE A . n 
A 1 401 ILE 401 401 401 ILE ILE A . n 
A 1 402 LYS 402 402 402 LYS LYS A . n 
A 1 403 ARG 403 403 403 ARG ARG A . n 
A 1 404 LEU 404 404 404 LEU LEU A . n 
A 1 405 PRO 405 405 405 PRO PRO A . n 
A 1 406 GLU 406 406 406 GLU GLU A . n 
A 1 407 ARG 407 407 407 ARG ARG A . n 
A 1 408 LEU 408 408 408 LEU LEU A . n 
A 1 409 PRO 409 409 409 PRO PRO A . n 
A 1 410 VAL 410 410 410 VAL VAL A . n 
A 1 411 LEU 411 411 411 LEU LEU A . n 
A 1 412 TRP 412 412 412 TRP TRP A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UYM 1   501 501 UYM CWW A . 
C 3 GUN 1   502 502 GUN GUA A . 
D 4 HEM 1   503 503 HEM DRG A . 
E 5 HOH 1   601 25  HOH HOH A . 
E 5 HOH 2   602 18  HOH HOH A . 
E 5 HOH 3   603 151 HOH HOH A . 
E 5 HOH 4   604 327 HOH HOH A . 
E 5 HOH 5   605 127 HOH HOH A . 
E 5 HOH 6   606 92  HOH HOH A . 
E 5 HOH 7   607 135 HOH HOH A . 
E 5 HOH 8   608 150 HOH HOH A . 
E 5 HOH 9   609 71  HOH HOH A . 
E 5 HOH 10  610 287 HOH HOH A . 
E 5 HOH 11  611 107 HOH HOH A . 
E 5 HOH 12  612 159 HOH HOH A . 
E 5 HOH 13  613 34  HOH HOH A . 
E 5 HOH 14  614 201 HOH HOH A . 
E 5 HOH 15  615 322 HOH HOH A . 
E 5 HOH 16  616 187 HOH HOH A . 
E 5 HOH 17  617 16  HOH HOH A . 
E 5 HOH 18  618 224 HOH HOH A . 
E 5 HOH 19  619 110 HOH HOH A . 
E 5 HOH 20  620 279 HOH HOH A . 
E 5 HOH 21  621 111 HOH HOH A . 
E 5 HOH 22  622 76  HOH HOH A . 
E 5 HOH 23  623 200 HOH HOH A . 
E 5 HOH 24  624 26  HOH HOH A . 
E 5 HOH 25  625 220 HOH HOH A . 
E 5 HOH 26  626 38  HOH HOH A . 
E 5 HOH 27  627 41  HOH HOH A . 
E 5 HOH 28  628 136 HOH HOH A . 
E 5 HOH 29  629 126 HOH HOH A . 
E 5 HOH 30  630 5   HOH HOH A . 
E 5 HOH 31  631 24  HOH HOH A . 
E 5 HOH 32  632 226 HOH HOH A . 
E 5 HOH 33  633 74  HOH HOH A . 
E 5 HOH 34  634 35  HOH HOH A . 
E 5 HOH 35  635 138 HOH HOH A . 
E 5 HOH 36  636 64  HOH HOH A . 
E 5 HOH 37  637 162 HOH HOH A . 
E 5 HOH 38  638 77  HOH HOH A . 
E 5 HOH 39  639 157 HOH HOH A . 
E 5 HOH 40  640 84  HOH HOH A . 
E 5 HOH 41  641 229 HOH HOH A . 
E 5 HOH 42  642 23  HOH HOH A . 
E 5 HOH 43  643 192 HOH HOH A . 
E 5 HOH 44  644 70  HOH HOH A . 
E 5 HOH 45  645 52  HOH HOH A . 
E 5 HOH 46  646 7   HOH HOH A . 
E 5 HOH 47  647 212 HOH HOH A . 
E 5 HOH 48  648 186 HOH HOH A . 
E 5 HOH 49  649 139 HOH HOH A . 
E 5 HOH 50  650 37  HOH HOH A . 
E 5 HOH 51  651 51  HOH HOH A . 
E 5 HOH 52  652 62  HOH HOH A . 
E 5 HOH 53  653 273 HOH HOH A . 
E 5 HOH 54  654 30  HOH HOH A . 
E 5 HOH 55  655 315 HOH HOH A . 
E 5 HOH 56  656 12  HOH HOH A . 
E 5 HOH 57  657 169 HOH HOH A . 
E 5 HOH 58  658 97  HOH HOH A . 
E 5 HOH 59  659 275 HOH HOH A . 
E 5 HOH 60  660 65  HOH HOH A . 
E 5 HOH 61  661 156 HOH HOH A . 
E 5 HOH 62  662 4   HOH HOH A . 
E 5 HOH 63  663 9   HOH HOH A . 
E 5 HOH 64  664 248 HOH HOH A . 
E 5 HOH 65  665 40  HOH HOH A . 
E 5 HOH 66  666 142 HOH HOH A . 
E 5 HOH 67  667 193 HOH HOH A . 
E 5 HOH 68  668 238 HOH HOH A . 
E 5 HOH 69  669 147 HOH HOH A . 
E 5 HOH 70  670 137 HOH HOH A . 
E 5 HOH 71  671 58  HOH HOH A . 
E 5 HOH 72  672 42  HOH HOH A . 
E 5 HOH 73  673 55  HOH HOH A . 
E 5 HOH 74  674 326 HOH HOH A . 
E 5 HOH 75  675 296 HOH HOH A . 
E 5 HOH 76  676 31  HOH HOH A . 
E 5 HOH 77  677 217 HOH HOH A . 
E 5 HOH 78  678 118 HOH HOH A . 
E 5 HOH 79  679 246 HOH HOH A . 
E 5 HOH 80  680 230 HOH HOH A . 
E 5 HOH 81  681 204 HOH HOH A . 
E 5 HOH 82  682 11  HOH HOH A . 
E 5 HOH 83  683 323 HOH HOH A . 
E 5 HOH 84  684 48  HOH HOH A . 
E 5 HOH 85  685 29  HOH HOH A . 
E 5 HOH 86  686 309 HOH HOH A . 
E 5 HOH 87  687 319 HOH HOH A . 
E 5 HOH 88  688 67  HOH HOH A . 
E 5 HOH 89  689 121 HOH HOH A . 
E 5 HOH 90  690 223 HOH HOH A . 
E 5 HOH 91  691 69  HOH HOH A . 
E 5 HOH 92  692 214 HOH HOH A . 
E 5 HOH 93  693 202 HOH HOH A . 
E 5 HOH 94  694 183 HOH HOH A . 
E 5 HOH 95  695 132 HOH HOH A . 
E 5 HOH 96  696 263 HOH HOH A . 
E 5 HOH 97  697 82  HOH HOH A . 
E 5 HOH 98  698 116 HOH HOH A . 
E 5 HOH 99  699 6   HOH HOH A . 
E 5 HOH 100 700 59  HOH HOH A . 
E 5 HOH 101 701 106 HOH HOH A . 
E 5 HOH 102 702 104 HOH HOH A . 
E 5 HOH 103 703 78  HOH HOH A . 
E 5 HOH 104 704 299 HOH HOH A . 
E 5 HOH 105 705 134 HOH HOH A . 
E 5 HOH 106 706 47  HOH HOH A . 
E 5 HOH 107 707 129 HOH HOH A . 
E 5 HOH 108 708 20  HOH HOH A . 
E 5 HOH 109 709 228 HOH HOH A . 
E 5 HOH 110 710 80  HOH HOH A . 
E 5 HOH 111 711 83  HOH HOH A . 
E 5 HOH 112 712 320 HOH HOH A . 
E 5 HOH 113 713 14  HOH HOH A . 
E 5 HOH 114 714 211 HOH HOH A . 
E 5 HOH 115 715 2   HOH HOH A . 
E 5 HOH 116 716 149 HOH HOH A . 
E 5 HOH 117 717 199 HOH HOH A . 
E 5 HOH 118 718 291 HOH HOH A . 
E 5 HOH 119 719 73  HOH HOH A . 
E 5 HOH 120 720 176 HOH HOH A . 
E 5 HOH 121 721 269 HOH HOH A . 
E 5 HOH 122 722 114 HOH HOH A . 
E 5 HOH 123 723 88  HOH HOH A . 
E 5 HOH 124 724 122 HOH HOH A . 
E 5 HOH 125 725 174 HOH HOH A . 
E 5 HOH 126 726 53  HOH HOH A . 
E 5 HOH 127 727 63  HOH HOH A . 
E 5 HOH 128 728 45  HOH HOH A . 
E 5 HOH 129 729 79  HOH HOH A . 
E 5 HOH 130 730 294 HOH HOH A . 
E 5 HOH 131 731 49  HOH HOH A . 
E 5 HOH 132 732 17  HOH HOH A . 
E 5 HOH 133 733 124 HOH HOH A . 
E 5 HOH 134 734 195 HOH HOH A . 
E 5 HOH 135 735 161 HOH HOH A . 
E 5 HOH 136 736 57  HOH HOH A . 
E 5 HOH 137 737 125 HOH HOH A . 
E 5 HOH 138 738 298 HOH HOH A . 
E 5 HOH 139 739 163 HOH HOH A . 
E 5 HOH 140 740 188 HOH HOH A . 
E 5 HOH 141 741 43  HOH HOH A . 
E 5 HOH 142 742 96  HOH HOH A . 
E 5 HOH 143 743 145 HOH HOH A . 
E 5 HOH 144 744 131 HOH HOH A . 
E 5 HOH 145 745 75  HOH HOH A . 
E 5 HOH 146 746 143 HOH HOH A . 
E 5 HOH 147 747 190 HOH HOH A . 
E 5 HOH 148 748 36  HOH HOH A . 
E 5 HOH 149 749 95  HOH HOH A . 
E 5 HOH 150 750 19  HOH HOH A . 
E 5 HOH 151 751 1   HOH HOH A . 
E 5 HOH 152 752 198 HOH HOH A . 
E 5 HOH 153 753 101 HOH HOH A . 
E 5 HOH 154 754 99  HOH HOH A . 
E 5 HOH 155 755 21  HOH HOH A . 
E 5 HOH 156 756 196 HOH HOH A . 
E 5 HOH 157 757 3   HOH HOH A . 
E 5 HOH 158 758 33  HOH HOH A . 
E 5 HOH 159 759 66  HOH HOH A . 
E 5 HOH 160 760 297 HOH HOH A . 
E 5 HOH 161 761 108 HOH HOH A . 
E 5 HOH 162 762 128 HOH HOH A . 
E 5 HOH 163 763 341 HOH HOH A . 
E 5 HOH 164 764 85  HOH HOH A . 
E 5 HOH 165 765 130 HOH HOH A . 
E 5 HOH 166 766 68  HOH HOH A . 
E 5 HOH 167 767 112 HOH HOH A . 
E 5 HOH 168 768 148 HOH HOH A . 
E 5 HOH 169 769 102 HOH HOH A . 
E 5 HOH 170 770 302 HOH HOH A . 
E 5 HOH 171 771 15  HOH HOH A . 
E 5 HOH 172 772 86  HOH HOH A . 
E 5 HOH 173 773 32  HOH HOH A . 
E 5 HOH 174 774 103 HOH HOH A . 
E 5 HOH 175 775 141 HOH HOH A . 
E 5 HOH 176 776 28  HOH HOH A . 
E 5 HOH 177 777 181 HOH HOH A . 
E 5 HOH 178 778 216 HOH HOH A . 
E 5 HOH 179 779 171 HOH HOH A . 
E 5 HOH 180 780 22  HOH HOH A . 
E 5 HOH 181 781 170 HOH HOH A . 
E 5 HOH 182 782 13  HOH HOH A . 
E 5 HOH 183 783 219 HOH HOH A . 
E 5 HOH 184 784 93  HOH HOH A . 
E 5 HOH 185 785 10  HOH HOH A . 
E 5 HOH 186 786 105 HOH HOH A . 
E 5 HOH 187 787 146 HOH HOH A . 
E 5 HOH 188 788 81  HOH HOH A . 
E 5 HOH 189 789 44  HOH HOH A . 
E 5 HOH 190 790 94  HOH HOH A . 
E 5 HOH 191 791 253 HOH HOH A . 
E 5 HOH 192 792 210 HOH HOH A . 
E 5 HOH 193 793 61  HOH HOH A . 
E 5 HOH 194 794 98  HOH HOH A . 
E 5 HOH 195 795 39  HOH HOH A . 
E 5 HOH 196 796 117 HOH HOH A . 
E 5 HOH 197 797 237 HOH HOH A . 
E 5 HOH 198 798 206 HOH HOH A . 
E 5 HOH 199 799 256 HOH HOH A . 
E 5 HOH 200 800 172 HOH HOH A . 
E 5 HOH 201 801 305 HOH HOH A . 
E 5 HOH 202 802 307 HOH HOH A . 
E 5 HOH 203 803 54  HOH HOH A . 
E 5 HOH 204 804 335 HOH HOH A . 
E 5 HOH 205 805 89  HOH HOH A . 
E 5 HOH 206 806 257 HOH HOH A . 
E 5 HOH 207 807 168 HOH HOH A . 
E 5 HOH 208 808 225 HOH HOH A . 
E 5 HOH 209 809 154 HOH HOH A . 
E 5 HOH 210 810 321 HOH HOH A . 
E 5 HOH 211 811 231 HOH HOH A . 
E 5 HOH 212 812 250 HOH HOH A . 
E 5 HOH 213 813 123 HOH HOH A . 
E 5 HOH 214 814 288 HOH HOH A . 
E 5 HOH 215 815 282 HOH HOH A . 
E 5 HOH 216 816 280 HOH HOH A . 
E 5 HOH 217 817 180 HOH HOH A . 
E 5 HOH 218 818 8   HOH HOH A . 
E 5 HOH 219 819 301 HOH HOH A . 
E 5 HOH 220 820 215 HOH HOH A . 
E 5 HOH 221 821 113 HOH HOH A . 
E 5 HOH 222 822 175 HOH HOH A . 
E 5 HOH 223 823 56  HOH HOH A . 
E 5 HOH 224 824 119 HOH HOH A . 
E 5 HOH 225 825 109 HOH HOH A . 
E 5 HOH 226 826 213 HOH HOH A . 
E 5 HOH 227 827 46  HOH HOH A . 
E 5 HOH 228 828 72  HOH HOH A . 
E 5 HOH 229 829 205 HOH HOH A . 
E 5 HOH 230 830 295 HOH HOH A . 
E 5 HOH 231 831 91  HOH HOH A . 
E 5 HOH 232 832 318 HOH HOH A . 
E 5 HOH 233 833 120 HOH HOH A . 
E 5 HOH 234 834 165 HOH HOH A . 
E 5 HOH 235 835 115 HOH HOH A . 
E 5 HOH 236 836 245 HOH HOH A . 
E 5 HOH 237 837 194 HOH HOH A . 
E 5 HOH 238 838 278 HOH HOH A . 
E 5 HOH 239 839 227 HOH HOH A . 
E 5 HOH 240 840 203 HOH HOH A . 
E 5 HOH 241 841 234 HOH HOH A . 
E 5 HOH 242 842 262 HOH HOH A . 
E 5 HOH 243 843 285 HOH HOH A . 
E 5 HOH 244 844 258 HOH HOH A . 
E 5 HOH 245 845 208 HOH HOH A . 
E 5 HOH 246 846 90  HOH HOH A . 
E 5 HOH 247 847 87  HOH HOH A . 
E 5 HOH 248 848 324 HOH HOH A . 
E 5 HOH 249 849 284 HOH HOH A . 
E 5 HOH 250 850 259 HOH HOH A . 
E 5 HOH 251 851 249 HOH HOH A . 
E 5 HOH 252 852 339 HOH HOH A . 
E 5 HOH 253 853 235 HOH HOH A . 
E 5 HOH 254 854 316 HOH HOH A . 
E 5 HOH 255 855 178 HOH HOH A . 
E 5 HOH 256 856 144 HOH HOH A . 
E 5 HOH 257 857 60  HOH HOH A . 
E 5 HOH 258 858 182 HOH HOH A . 
E 5 HOH 259 859 160 HOH HOH A . 
E 5 HOH 260 860 274 HOH HOH A . 
E 5 HOH 261 861 254 HOH HOH A . 
E 5 HOH 262 862 233 HOH HOH A . 
E 5 HOH 263 863 232 HOH HOH A . 
E 5 HOH 264 864 342 HOH HOH A . 
E 5 HOH 265 865 209 HOH HOH A . 
E 5 HOH 266 866 314 HOH HOH A . 
E 5 HOH 267 867 266 HOH HOH A . 
E 5 HOH 268 868 152 HOH HOH A . 
E 5 HOH 269 869 236 HOH HOH A . 
E 5 HOH 270 870 270 HOH HOH A . 
E 5 HOH 271 871 313 HOH HOH A . 
E 5 HOH 272 872 243 HOH HOH A . 
E 5 HOH 273 873 343 HOH HOH A . 
E 5 HOH 274 874 329 HOH HOH A . 
E 5 HOH 275 875 244 HOH HOH A . 
E 5 HOH 276 876 173 HOH HOH A . 
E 5 HOH 277 877 133 HOH HOH A . 
E 5 HOH 278 878 334 HOH HOH A . 
E 5 HOH 279 879 164 HOH HOH A . 
E 5 HOH 280 880 240 HOH HOH A . 
E 5 HOH 281 881 255 HOH HOH A . 
E 5 HOH 282 882 153 HOH HOH A . 
E 5 HOH 283 883 265 HOH HOH A . 
E 5 HOH 284 884 247 HOH HOH A . 
E 5 HOH 285 885 293 HOH HOH A . 
E 5 HOH 286 886 312 HOH HOH A . 
E 5 HOH 287 887 222 HOH HOH A . 
E 5 HOH 288 888 345 HOH HOH A . 
E 5 HOH 289 889 155 HOH HOH A . 
E 5 HOH 290 890 167 HOH HOH A . 
E 5 HOH 291 891 336 HOH HOH A . 
E 5 HOH 292 892 340 HOH HOH A . 
E 5 HOH 293 893 207 HOH HOH A . 
E 5 HOH 294 894 317 HOH HOH A . 
E 5 HOH 295 895 140 HOH HOH A . 
E 5 HOH 296 896 264 HOH HOH A . 
E 5 HOH 297 897 251 HOH HOH A . 
E 5 HOH 298 898 272 HOH HOH A . 
E 5 HOH 299 899 267 HOH HOH A . 
E 5 HOH 300 900 283 HOH HOH A . 
E 5 HOH 301 901 268 HOH HOH A . 
E 5 HOH 302 902 330 HOH HOH A . 
E 5 HOH 303 903 27  HOH HOH A . 
E 5 HOH 304 904 242 HOH HOH A . 
E 5 HOH 305 905 239 HOH HOH A . 
E 5 HOH 306 906 271 HOH HOH A . 
E 5 HOH 307 907 286 HOH HOH A . 
E 5 HOH 308 908 325 HOH HOH A . 
E 5 HOH 309 909 333 HOH HOH A . 
E 5 HOH 310 910 344 HOH HOH A . 
E 5 HOH 311 911 292 HOH HOH A . 
E 5 HOH 312 912 179 HOH HOH A . 
E 5 HOH 313 913 276 HOH HOH A . 
E 5 HOH 314 914 252 HOH HOH A . 
E 5 HOH 315 915 50  HOH HOH A . 
E 5 HOH 316 916 310 HOH HOH A . 
E 5 HOH 317 917 304 HOH HOH A . 
E 5 HOH 318 918 158 HOH HOH A . 
E 5 HOH 319 919 221 HOH HOH A . 
E 5 HOH 320 920 328 HOH HOH A . 
E 5 HOH 321 921 189 HOH HOH A . 
E 5 HOH 322 922 331 HOH HOH A . 
E 5 HOH 323 923 277 HOH HOH A . 
E 5 HOH 324 924 185 HOH HOH A . 
E 5 HOH 325 925 337 HOH HOH A . 
E 5 HOH 326 926 218 HOH HOH A . 
E 5 HOH 327 927 166 HOH HOH A . 
E 5 HOH 328 928 281 HOH HOH A . 
E 5 HOH 329 929 241 HOH HOH A . 
E 5 HOH 330 930 308 HOH HOH A . 
E 5 HOH 331 931 289 HOH HOH A . 
E 5 HOH 332 932 303 HOH HOH A . 
E 5 HOH 333 933 311 HOH HOH A . 
E 5 HOH 334 934 191 HOH HOH A . 
E 5 HOH 335 935 290 HOH HOH A . 
E 5 HOH 336 936 100 HOH HOH A . 
E 5 HOH 337 937 177 HOH HOH A . 
E 5 HOH 338 938 261 HOH HOH A . 
E 5 HOH 339 939 184 HOH HOH A . 
E 5 HOH 340 940 197 HOH HOH A . 
E 5 HOH 341 941 306 HOH HOH A . 
E 5 HOH 342 942 300 HOH HOH A . 
E 5 HOH 343 943 332 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ARG 122 ? CG  ? A ARG 122 CG  
2  1 Y 1 A ARG 122 ? CD  ? A ARG 122 CD  
3  1 Y 1 A ARG 122 ? NE  ? A ARG 122 NE  
4  1 Y 1 A ARG 122 ? CZ  ? A ARG 122 CZ  
5  1 Y 1 A ARG 122 ? NH1 ? A ARG 122 NH1 
6  1 Y 1 A ARG 122 ? NH2 ? A ARG 122 NH2 
7  1 Y 1 A ARG 138 ? CG  ? A ARG 138 CG  
8  1 Y 1 A ARG 138 ? CD  ? A ARG 138 CD  
9  1 Y 1 A ARG 138 ? NE  ? A ARG 138 NE  
10 1 Y 1 A ARG 138 ? CZ  ? A ARG 138 CZ  
11 1 Y 1 A ARG 138 ? NH1 ? A ARG 138 NH1 
12 1 Y 1 A ARG 138 ? NH2 ? A ARG 138 NH2 
13 1 Y 1 A ARG 174 ? CG  ? A ARG 174 CG  
14 1 Y 1 A ARG 174 ? CD  ? A ARG 174 CD  
15 1 Y 1 A ARG 174 ? NE  ? A ARG 174 NE  
16 1 Y 1 A ARG 174 ? CZ  ? A ARG 174 CZ  
17 1 Y 1 A ARG 174 ? NH1 ? A ARG 174 NH1 
18 1 Y 1 A ARG 174 ? NH2 ? A ARG 174 NH2 
19 1 Y 1 A ASP 211 ? CG  ? A ASP 211 CG  
20 1 Y 1 A ASP 211 ? OD1 ? A ASP 211 OD1 
21 1 Y 1 A ASP 211 ? OD2 ? A ASP 211 OD2 
22 1 Y 1 A GLU 224 ? CG  ? A GLU 224 CG  
23 1 Y 1 A GLU 224 ? CD  ? A GLU 224 CD  
24 1 Y 1 A GLU 224 ? OE1 ? A GLU 224 OE1 
25 1 Y 1 A GLU 224 ? OE2 ? A GLU 224 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? '(1.19.2_4158: ???)' 1 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT ? ? ? .                    2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS         ? ? ? .                    3 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .                    4 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? .                    5 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YZA 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     88.574 
_cell.length_a_esd                 ? 
_cell.length_b                     88.574 
_cell.length_b_esd                 ? 
_cell.length_c                     138.933 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YZA 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                95 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 43 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YZA 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.71 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.68 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1M Bis-Tris pH 5.5
0.2M Ammonium acetate
25% PEG3350
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-01 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9785 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9785 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8YZA 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.0 
_reflns.d_resolution_low                               24.9 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38077 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.91 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                25.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          20.04 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.0 
_reflns_shell.d_res_low                                     2.071 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3717 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.916 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YZA 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             24.90 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     38076 
_refine.ls_number_reflns_R_free                  1886 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    100.00 
_refine.ls_percent_reflns_R_free                 4.95 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1754 
_refine.ls_R_factor_R_free                       0.2074 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1916 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 19.69 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.15 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        24.90 
_refine_hist.number_atoms_solvent             343 
_refine_hist.number_atoms_total               3427 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3002 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         82 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007 ? 3225 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.880 ? 4405 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 5.458 ? 511  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.051 ? 481  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.009 ? 594  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.05  . . 131 2758 100.00 . . . . 0.2106 . . . . . . . . . . . 0.2663 
'X-RAY DIFFRACTION' 2.05 2.11  . . 135 2730 100.00 . . . . 0.1983 . . . . . . . . . . . 0.2528 
'X-RAY DIFFRACTION' 2.11 2.18  . . 130 2722 100.00 . . . . 0.1885 . . . . . . . . . . . 0.1892 
'X-RAY DIFFRACTION' 2.18 2.26  . . 135 2770 100.00 . . . . 0.1872 . . . . . . . . . . . 0.2270 
'X-RAY DIFFRACTION' 2.26 2.35  . . 142 2732 100.00 . . . . 0.1826 . . . . . . . . . . . 0.2238 
'X-RAY DIFFRACTION' 2.35 2.46  . . 145 2771 100.00 . . . . 0.1799 . . . . . . . . . . . 0.1940 
'X-RAY DIFFRACTION' 2.46 2.59  . . 153 2720 100.00 . . . . 0.1897 . . . . . . . . . . . 0.1920 
'X-RAY DIFFRACTION' 2.59 2.75  . . 127 2803 100.00 . . . . 0.1856 . . . . . . . . . . . 0.2108 
'X-RAY DIFFRACTION' 2.75 2.96  . . 144 2771 100.00 . . . . 0.1891 . . . . . . . . . . . 0.1995 
'X-RAY DIFFRACTION' 2.96 3.26  . . 146 2788 100.00 . . . . 0.1887 . . . . . . . . . . . 0.1879 
'X-RAY DIFFRACTION' 3.26 3.73  . . 163 2788 100.00 . . . . 0.1745 . . . . . . . . . . . 0.2068 
'X-RAY DIFFRACTION' 3.73 4.69  . . 158 2853 100.00 . . . . 0.1505 . . . . . . . . . . . 0.1634 
'X-RAY DIFFRACTION' 4.69 24.90 . . 177 2984 100.00 . . . . 0.1646 . . . . . . . . . . . 0.1721 
# 
_struct.entry_id                     8YZA 
_struct.title                        'Crystal structure of PtmB in complex with cyclo-(L-Trp-L-Trp) and Guanine' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YZA 
_struct_keywords.text            'P450 oxidoreductase, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8YZA 
_struct_ref.pdbx_db_accession          8YZA 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YZA 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 412 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8YZA 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  412 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       412 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5830  ? 
1 MORE         -55   ? 
1 'SSA (A^2)'  29440 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z   1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 5_555 -x,y,-z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 33  ? GLN A 43  ? PRO A 33  GLN A 43  1 ? 11 
HELX_P HELX_P2  AA2 SER A 61  ? ASP A 71  ? SER A 61  ASP A 71  1 ? 11 
HELX_P HELX_P3  AA3 LEU A 76  ? ASN A 81  ? LEU A 76  ASN A 81  5 ? 6  
HELX_P HELX_P4  AA4 PRO A 93  ? ASN A 98  ? PRO A 93  ASN A 98  1 ? 6  
HELX_P HELX_P5  AA5 ASN A 98  ? ALA A 106 ? ASN A 98  ALA A 106 1 ? 9  
HELX_P HELX_P6  AA6 LEU A 108 ? SER A 117 ? LEU A 108 SER A 117 1 ? 10 
HELX_P HELX_P7  AA7 PRO A 118 ? ASP A 121 ? PRO A 118 ASP A 121 5 ? 4  
HELX_P HELX_P8  AA8 GLU A 123 ? GLY A 143 ? GLU A 123 GLY A 143 1 ? 21 
HELX_P HELX_P9  AA9 PHE A 152 ? GLY A 166 ? PHE A 152 GLY A 166 1 ? 15 
HELX_P HELX_P10 AB1 ASP A 171 ? PHE A 183 ? ASP A 171 PHE A 183 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 192 ? ASN A 209 ? GLY A 192 ASN A 209 1 ? 18 
HELX_P HELX_P12 AB3 GLU A 216 ? SER A 228 ? GLU A 216 SER A 228 1 ? 13 
HELX_P HELX_P13 AB4 SER A 236 ? GLN A 269 ? SER A 236 GLN A 269 1 ? 34 
HELX_P HELX_P14 AB5 GLN A 269 ? GLU A 279 ? GLN A 269 GLU A 279 1 ? 11 
HELX_P HELX_P15 AB6 VAL A 282 ? ASN A 294 ? VAL A 282 ASN A 294 1 ? 13 
HELX_P HELX_P16 AB7 LEU A 325 ? TYR A 331 ? LEU A 325 TYR A 331 1 ? 7  
HELX_P HELX_P17 AB8 GLY A 356 ? PHE A 360 ? GLY A 356 PHE A 360 5 ? 5  
HELX_P HELX_P18 AB9 ALA A 363 ? LEU A 382 ? ALA A 363 LEU A 382 1 ? 20 
HELX_P HELX_P19 AC1 PRO A 390 ? LEU A 394 ? PRO A 390 LEU A 394 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            metalc1 
_struct_conn.conn_type_id                  metalc 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            361 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           D 
_struct_conn.ptnr2_label_comp_id           HEM 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           FE 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             361 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            HEM 
_struct_conn.ptnr2_auth_seq_id             503 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.490 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG ? A CYS 361 ? A CYS 361 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 NA ? D HEM . ? A HEM 503 ? 1_555 104.7 ? 
2  SG ? A CYS 361 ? A CYS 361 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 NB ? D HEM . ? A HEM 503 ? 1_555 98.7  ? 
3  NA ? D HEM .   ? A HEM 503 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 NB ? D HEM . ? A HEM 503 ? 1_555 89.5  ? 
4  SG ? A CYS 361 ? A CYS 361 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 NC ? D HEM . ? A HEM 503 ? 1_555 93.6  ? 
5  NA ? D HEM .   ? A HEM 503 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 NC ? D HEM . ? A HEM 503 ? 1_555 161.7 ? 
6  NB ? D HEM .   ? A HEM 503 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 NC ? D HEM . ? A HEM 503 ? 1_555 87.5  ? 
7  SG ? A CYS 361 ? A CYS 361 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 ND ? D HEM . ? A HEM 503 ? 1_555 106.1 ? 
8  NA ? D HEM .   ? A HEM 503 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 ND ? D HEM . ? A HEM 503 ? 1_555 88.6  ? 
9  NB ? D HEM .   ? A HEM 503 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 ND ? D HEM . ? A HEM 503 ? 1_555 154.9 ? 
10 NC ? D HEM .   ? A HEM 503 ? 1_555 FE ? D HEM . ? A HEM 503 ? 1_555 ND ? D HEM . ? A HEM 503 ? 1_555 86.5  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 23  A . ? PHE 23  A PRO 24  A ? PRO 24  A 1 8.48  
2 PRO 144 A . ? PRO 144 A PRO 145 A ? PRO 145 A 1 -1.29 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 45  ? ARG A 49  ? VAL A 45  ARG A 49  
AA1 2 GLU A 55  ? VAL A 59  ? GLU A 55  VAL A 59  
AA1 3 LEU A 321 ? VAL A 324 ? LEU A 321 VAL A 324 
AA1 4 LEU A 301 ? ALA A 305 ? LEU A 301 ALA A 305 
AA1 5 PHE A 74  ? SER A 75  ? PHE A 74  SER A 75  
AA2 1 ALA A 146 ? ASP A 147 ? ALA A 146 ASP A 147 
AA2 2 PRO A 409 ? LEU A 411 ? PRO A 409 LEU A 411 
AA2 3 ARG A 386 ? LEU A 387 ? ARG A 386 LEU A 387 
AA3 1 VAL A 309 ? LEU A 311 ? VAL A 309 LEU A 311 
AA3 2 VAL A 314 ? ILE A 316 ? VAL A 314 ILE A 316 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 46  ? N ALA A 46  O LEU A 58  ? O LEU A 58  
AA1 2 3 N TRP A 57  ? N TRP A 57  O LEU A 323 ? O LEU A 323 
AA1 3 4 O VAL A 322 ? O VAL A 322 N ARG A 303 ? N ARG A 303 
AA1 4 5 O ILE A 304 ? O ILE A 304 N SER A 75  ? N SER A 75  
AA2 1 2 N ALA A 146 ? N ALA A 146 O VAL A 410 ? O VAL A 410 
AA2 2 3 O LEU A 411 ? O LEU A 411 N ARG A 386 ? N ARG A 386 
AA3 1 2 N VAL A 309 ? N VAL A 309 O ILE A 316 ? O ILE A 316 
# 
_pdbx_entry_details.entry_id                   8YZA 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 GLN A 43  ? ? -151.60 73.76   
2 1 ASN A 98  ? ? -95.11  37.72   
3 1 PHE A 152 ? ? -142.63 -76.34  
4 1 PRO A 212 ? ? -64.69  79.20   
5 1 GLU A 216 ? ? 70.88   136.23  
6 1 ASP A 299 ? ? -129.97 -169.46 
7 1 HIS A 338 ? ? 31.46   62.06   
8 1 LEU A 382 ? ? -119.64 70.63   
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     699 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   E 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       943 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.29 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A THR 2   ? A THR 2   
3  1 Y 1 A THR 3   ? A THR 3   
4  1 Y 1 A THR 4   ? A THR 4   
5  1 Y 1 A ALA 5   ? A ALA 5   
6  1 Y 1 A GLN 6   ? A GLN 6   
7  1 Y 1 A ARG 7   ? A ARG 7   
8  1 Y 1 A ASP 8   ? A ASP 8   
9  1 Y 1 A PRO 9   ? A PRO 9   
10 1 Y 1 A VAL 10  ? A VAL 10  
11 1 Y 1 A LEU 11  ? A LEU 11  
12 1 Y 1 A PRO 12  ? A PRO 12  
13 1 Y 1 A GLY 13  ? A GLY 13  
14 1 Y 1 A THR 14  ? A THR 14  
15 1 Y 1 A ALA 15  ? A ALA 15  
16 1 Y 1 A HIS 16  ? A HIS 16  
17 1 Y 1 A HIS 17  ? A HIS 17  
18 1 Y 1 A ASP 230 ? A ASP 230 
19 1 Y 1 A VAL 231 ? A VAL 231 
20 1 Y 1 A SER 232 ? A SER 232 
21 1 Y 1 A ASP 233 ? A ASP 233 
22 1 Y 1 A GLN 234 ? A GLN 234 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
GUN N9   N  Y N 137 
GUN C8   C  Y N 138 
GUN N7   N  Y N 139 
GUN C5   C  Y N 140 
GUN C6   C  N N 141 
GUN O6   O  N N 142 
GUN N1   N  N N 143 
GUN C2   C  N N 144 
GUN N2   N  N N 145 
GUN N3   N  N N 146 
GUN C4   C  Y N 147 
GUN HN9  H  N N 148 
GUN H8   H  N N 149 
GUN HN1  H  N N 150 
GUN HN21 H  N N 151 
GUN HN22 H  N N 152 
HEM CHA  C  N N 153 
HEM CHB  C  N N 154 
HEM CHC  C  N N 155 
HEM CHD  C  N N 156 
HEM C1A  C  Y N 157 
HEM C2A  C  Y N 158 
HEM C3A  C  Y N 159 
HEM C4A  C  Y N 160 
HEM CMA  C  N N 161 
HEM CAA  C  N N 162 
HEM CBA  C  N N 163 
HEM CGA  C  N N 164 
HEM O1A  O  N N 165 
HEM O2A  O  N N 166 
HEM C1B  C  N N 167 
HEM C2B  C  N N 168 
HEM C3B  C  N N 169 
HEM C4B  C  N N 170 
HEM CMB  C  N N 171 
HEM CAB  C  N N 172 
HEM CBB  C  N N 173 
HEM C1C  C  Y N 174 
HEM C2C  C  Y N 175 
HEM C3C  C  Y N 176 
HEM C4C  C  Y N 177 
HEM CMC  C  N N 178 
HEM CAC  C  N N 179 
HEM CBC  C  N N 180 
HEM C1D  C  N N 181 
HEM C2D  C  N N 182 
HEM C3D  C  N N 183 
HEM C4D  C  N N 184 
HEM CMD  C  N N 185 
HEM CAD  C  N N 186 
HEM CBD  C  N N 187 
HEM CGD  C  N N 188 
HEM O1D  O  N N 189 
HEM O2D  O  N N 190 
HEM NA   N  Y N 191 
HEM NB   N  N N 192 
HEM NC   N  Y N 193 
HEM ND   N  N N 194 
HEM FE   FE N N 195 
HEM HHB  H  N N 196 
HEM HHC  H  N N 197 
HEM HHD  H  N N 198 
HEM HMA  H  N N 199 
HEM HMAA H  N N 200 
HEM HMAB H  N N 201 
HEM HAA  H  N N 202 
HEM HAAA H  N N 203 
HEM HBA  H  N N 204 
HEM HBAA H  N N 205 
HEM HMB  H  N N 206 
HEM HMBA H  N N 207 
HEM HMBB H  N N 208 
HEM HAB  H  N N 209 
HEM HBB  H  N N 210 
HEM HBBA H  N N 211 
HEM HMC  H  N N 212 
HEM HMCA H  N N 213 
HEM HMCB H  N N 214 
HEM HAC  H  N N 215 
HEM HBC  H  N N 216 
HEM HBCA H  N N 217 
HEM HMD  H  N N 218 
HEM HMDA H  N N 219 
HEM HMDB H  N N 220 
HEM HAD  H  N N 221 
HEM HADA H  N N 222 
HEM HBD  H  N N 223 
HEM HBDA H  N N 224 
HEM H2A  H  N N 225 
HEM H2D  H  N N 226 
HEM HHA  H  N N 227 
HIS N    N  N N 228 
HIS CA   C  N S 229 
HIS C    C  N N 230 
HIS O    O  N N 231 
HIS CB   C  N N 232 
HIS CG   C  Y N 233 
HIS ND1  N  Y N 234 
HIS CD2  C  Y N 235 
HIS CE1  C  Y N 236 
HIS NE2  N  Y N 237 
HIS OXT  O  N N 238 
HIS H    H  N N 239 
HIS H2   H  N N 240 
HIS HA   H  N N 241 
HIS HB2  H  N N 242 
HIS HB3  H  N N 243 
HIS HD1  H  N N 244 
HIS HD2  H  N N 245 
HIS HE1  H  N N 246 
HIS HE2  H  N N 247 
HIS HXT  H  N N 248 
HOH O    O  N N 249 
HOH H1   H  N N 250 
HOH H2   H  N N 251 
ILE N    N  N N 252 
ILE CA   C  N S 253 
ILE C    C  N N 254 
ILE O    O  N N 255 
ILE CB   C  N S 256 
ILE CG1  C  N N 257 
ILE CG2  C  N N 258 
ILE CD1  C  N N 259 
ILE OXT  O  N N 260 
ILE H    H  N N 261 
ILE H2   H  N N 262 
ILE HA   H  N N 263 
ILE HB   H  N N 264 
ILE HG12 H  N N 265 
ILE HG13 H  N N 266 
ILE HG21 H  N N 267 
ILE HG22 H  N N 268 
ILE HG23 H  N N 269 
ILE HD11 H  N N 270 
ILE HD12 H  N N 271 
ILE HD13 H  N N 272 
ILE HXT  H  N N 273 
LEU N    N  N N 274 
LEU CA   C  N S 275 
LEU C    C  N N 276 
LEU O    O  N N 277 
LEU CB   C  N N 278 
LEU CG   C  N N 279 
LEU CD1  C  N N 280 
LEU CD2  C  N N 281 
LEU OXT  O  N N 282 
LEU H    H  N N 283 
LEU H2   H  N N 284 
LEU HA   H  N N 285 
LEU HB2  H  N N 286 
LEU HB3  H  N N 287 
LEU HG   H  N N 288 
LEU HD11 H  N N 289 
LEU HD12 H  N N 290 
LEU HD13 H  N N 291 
LEU HD21 H  N N 292 
LEU HD22 H  N N 293 
LEU HD23 H  N N 294 
LEU HXT  H  N N 295 
LYS N    N  N N 296 
LYS CA   C  N S 297 
LYS C    C  N N 298 
LYS O    O  N N 299 
LYS CB   C  N N 300 
LYS CG   C  N N 301 
LYS CD   C  N N 302 
LYS CE   C  N N 303 
LYS NZ   N  N N 304 
LYS OXT  O  N N 305 
LYS H    H  N N 306 
LYS H2   H  N N 307 
LYS HA   H  N N 308 
LYS HB2  H  N N 309 
LYS HB3  H  N N 310 
LYS HG2  H  N N 311 
LYS HG3  H  N N 312 
LYS HD2  H  N N 313 
LYS HD3  H  N N 314 
LYS HE2  H  N N 315 
LYS HE3  H  N N 316 
LYS HZ1  H  N N 317 
LYS HZ2  H  N N 318 
LYS HZ3  H  N N 319 
LYS HXT  H  N N 320 
MET N    N  N N 321 
MET CA   C  N S 322 
MET C    C  N N 323 
MET O    O  N N 324 
MET CB   C  N N 325 
MET CG   C  N N 326 
MET SD   S  N N 327 
MET CE   C  N N 328 
MET OXT  O  N N 329 
MET H    H  N N 330 
MET H2   H  N N 331 
MET HA   H  N N 332 
MET HB2  H  N N 333 
MET HB3  H  N N 334 
MET HG2  H  N N 335 
MET HG3  H  N N 336 
MET HE1  H  N N 337 
MET HE2  H  N N 338 
MET HE3  H  N N 339 
MET HXT  H  N N 340 
PHE N    N  N N 341 
PHE CA   C  N S 342 
PHE C    C  N N 343 
PHE O    O  N N 344 
PHE CB   C  N N 345 
PHE CG   C  Y N 346 
PHE CD1  C  Y N 347 
PHE CD2  C  Y N 348 
PHE CE1  C  Y N 349 
PHE CE2  C  Y N 350 
PHE CZ   C  Y N 351 
PHE OXT  O  N N 352 
PHE H    H  N N 353 
PHE H2   H  N N 354 
PHE HA   H  N N 355 
PHE HB2  H  N N 356 
PHE HB3  H  N N 357 
PHE HD1  H  N N 358 
PHE HD2  H  N N 359 
PHE HE1  H  N N 360 
PHE HE2  H  N N 361 
PHE HZ   H  N N 362 
PHE HXT  H  N N 363 
PRO N    N  N N 364 
PRO CA   C  N S 365 
PRO C    C  N N 366 
PRO O    O  N N 367 
PRO CB   C  N N 368 
PRO CG   C  N N 369 
PRO CD   C  N N 370 
PRO OXT  O  N N 371 
PRO H    H  N N 372 
PRO HA   H  N N 373 
PRO HB2  H  N N 374 
PRO HB3  H  N N 375 
PRO HG2  H  N N 376 
PRO HG3  H  N N 377 
PRO HD2  H  N N 378 
PRO HD3  H  N N 379 
PRO HXT  H  N N 380 
SER N    N  N N 381 
SER CA   C  N S 382 
SER C    C  N N 383 
SER O    O  N N 384 
SER CB   C  N N 385 
SER OG   O  N N 386 
SER OXT  O  N N 387 
SER H    H  N N 388 
SER H2   H  N N 389 
SER HA   H  N N 390 
SER HB2  H  N N 391 
SER HB3  H  N N 392 
SER HG   H  N N 393 
SER HXT  H  N N 394 
THR N    N  N N 395 
THR CA   C  N S 396 
THR C    C  N N 397 
THR O    O  N N 398 
THR CB   C  N R 399 
THR OG1  O  N N 400 
THR CG2  C  N N 401 
THR OXT  O  N N 402 
THR H    H  N N 403 
THR H2   H  N N 404 
THR HA   H  N N 405 
THR HB   H  N N 406 
THR HG1  H  N N 407 
THR HG21 H  N N 408 
THR HG22 H  N N 409 
THR HG23 H  N N 410 
THR HXT  H  N N 411 
TRP N    N  N N 412 
TRP CA   C  N S 413 
TRP C    C  N N 414 
TRP O    O  N N 415 
TRP CB   C  N N 416 
TRP CG   C  Y N 417 
TRP CD1  C  Y N 418 
TRP CD2  C  Y N 419 
TRP NE1  N  Y N 420 
TRP CE2  C  Y N 421 
TRP CE3  C  Y N 422 
TRP CZ2  C  Y N 423 
TRP CZ3  C  Y N 424 
TRP CH2  C  Y N 425 
TRP OXT  O  N N 426 
TRP H    H  N N 427 
TRP H2   H  N N 428 
TRP HA   H  N N 429 
TRP HB2  H  N N 430 
TRP HB3  H  N N 431 
TRP HD1  H  N N 432 
TRP HE1  H  N N 433 
TRP HE3  H  N N 434 
TRP HZ2  H  N N 435 
TRP HZ3  H  N N 436 
TRP HH2  H  N N 437 
TRP HXT  H  N N 438 
TYR N    N  N N 439 
TYR CA   C  N S 440 
TYR C    C  N N 441 
TYR O    O  N N 442 
TYR CB   C  N N 443 
TYR CG   C  Y N 444 
TYR CD1  C  Y N 445 
TYR CD2  C  Y N 446 
TYR CE1  C  Y N 447 
TYR CE2  C  Y N 448 
TYR CZ   C  Y N 449 
TYR OH   O  N N 450 
TYR OXT  O  N N 451 
TYR H    H  N N 452 
TYR H2   H  N N 453 
TYR HA   H  N N 454 
TYR HB2  H  N N 455 
TYR HB3  H  N N 456 
TYR HD1  H  N N 457 
TYR HD2  H  N N 458 
TYR HE1  H  N N 459 
TYR HE2  H  N N 460 
TYR HH   H  N N 461 
TYR HXT  H  N N 462 
UYM N    N  Y N 463 
UYM C    C  N N 464 
UYM O    O  N N 465 
UYM C1   C  N S 466 
UYM C10  C  Y N 467 
UYM C11  C  N S 468 
UYM C12  C  N N 469 
UYM C15  C  N N 470 
UYM C2   C  N N 471 
UYM C3   C  Y N 472 
UYM C34  C  Y N 473 
UYM C35  C  Y N 474 
UYM C37  C  Y N 475 
UYM C38  C  Y N 476 
UYM C39  C  Y N 477 
UYM C4   C  Y N 478 
UYM C40  C  Y N 479 
UYM C41  C  Y N 480 
UYM C42  C  Y N 481 
UYM C5   C  Y N 482 
UYM C6   C  Y N 483 
UYM C7   C  Y N 484 
UYM C8   C  Y N 485 
UYM C9   C  Y N 486 
UYM N1   N  N N 487 
UYM N2   N  N N 488 
UYM N36  N  Y N 489 
UYM O1   O  N N 490 
UYM H1   H  N N 491 
UYM H2   H  N N 492 
UYM H3   H  N N 493 
UYM H4   H  N N 494 
UYM H5   H  N N 495 
UYM H6   H  N N 496 
UYM H7   H  N N 497 
UYM H8   H  N N 498 
UYM H9   H  N N 499 
UYM H10  H  N N 500 
UYM H11  H  N N 501 
UYM H12  H  N N 502 
UYM H13  H  N N 503 
UYM H14  H  N N 504 
UYM H15  H  N N 505 
UYM H16  H  N N 506 
UYM H17  H  N N 507 
UYM H18  H  N N 508 
UYM H19  H  N N 509 
UYM H20  H  N N 510 
VAL N    N  N N 511 
VAL CA   C  N S 512 
VAL C    C  N N 513 
VAL O    O  N N 514 
VAL CB   C  N N 515 
VAL CG1  C  N N 516 
VAL CG2  C  N N 517 
VAL OXT  O  N N 518 
VAL H    H  N N 519 
VAL H2   H  N N 520 
VAL HA   H  N N 521 
VAL HB   H  N N 522 
VAL HG11 H  N N 523 
VAL HG12 H  N N 524 
VAL HG13 H  N N 525 
VAL HG21 H  N N 526 
VAL HG22 H  N N 527 
VAL HG23 H  N N 528 
VAL HXT  H  N N 529 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
GUN N9  C8   sing Y N 129 
GUN N9  C4   sing Y N 130 
GUN N9  HN9  sing N N 131 
GUN C8  N7   doub Y N 132 
GUN C8  H8   sing N N 133 
GUN N7  C5   sing Y N 134 
GUN C5  C6   sing N N 135 
GUN C5  C4   doub Y N 136 
GUN C6  O6   doub N N 137 
GUN C6  N1   sing N N 138 
GUN N1  C2   sing N N 139 
GUN N1  HN1  sing N N 140 
GUN C2  N2   sing N N 141 
GUN C2  N3   doub N N 142 
GUN N2  HN21 sing N N 143 
GUN N2  HN22 sing N N 144 
GUN N3  C4   sing N N 145 
HEM CHA C1A  sing N N 146 
HEM CHA C4D  doub N N 147 
HEM CHA HHA  sing N N 148 
HEM CHB C4A  sing N N 149 
HEM CHB C1B  doub N N 150 
HEM CHB HHB  sing N N 151 
HEM CHC C4B  sing N N 152 
HEM CHC C1C  doub N N 153 
HEM CHC HHC  sing N N 154 
HEM CHD C4C  doub N N 155 
HEM CHD C1D  sing N N 156 
HEM CHD HHD  sing N N 157 
HEM C1A C2A  doub Y N 158 
HEM C1A NA   sing Y N 159 
HEM C2A C3A  sing Y N 160 
HEM C2A CAA  sing N N 161 
HEM C3A C4A  doub Y N 162 
HEM C3A CMA  sing N N 163 
HEM C4A NA   sing Y N 164 
HEM CMA HMA  sing N N 165 
HEM CMA HMAA sing N N 166 
HEM CMA HMAB sing N N 167 
HEM CAA CBA  sing N N 168 
HEM CAA HAA  sing N N 169 
HEM CAA HAAA sing N N 170 
HEM CBA CGA  sing N N 171 
HEM CBA HBA  sing N N 172 
HEM CBA HBAA sing N N 173 
HEM CGA O1A  doub N N 174 
HEM CGA O2A  sing N N 175 
HEM C1B C2B  sing N N 176 
HEM C1B NB   sing N N 177 
HEM C2B C3B  doub N N 178 
HEM C2B CMB  sing N N 179 
HEM C3B C4B  sing N N 180 
HEM C3B CAB  sing N N 181 
HEM C4B NB   doub N N 182 
HEM CMB HMB  sing N N 183 
HEM CMB HMBA sing N N 184 
HEM CMB HMBB sing N N 185 
HEM CAB CBB  doub N N 186 
HEM CAB HAB  sing N N 187 
HEM CBB HBB  sing N N 188 
HEM CBB HBBA sing N N 189 
HEM C1C C2C  sing Y N 190 
HEM C1C NC   sing Y N 191 
HEM C2C C3C  doub Y N 192 
HEM C2C CMC  sing N N 193 
HEM C3C C4C  sing Y N 194 
HEM C3C CAC  sing N N 195 
HEM C4C NC   sing Y N 196 
HEM CMC HMC  sing N N 197 
HEM CMC HMCA sing N N 198 
HEM CMC HMCB sing N N 199 
HEM CAC CBC  doub N N 200 
HEM CAC HAC  sing N N 201 
HEM CBC HBC  sing N N 202 
HEM CBC HBCA sing N N 203 
HEM C1D C2D  sing N N 204 
HEM C1D ND   doub N N 205 
HEM C2D C3D  doub N N 206 
HEM C2D CMD  sing N N 207 
HEM C3D C4D  sing N N 208 
HEM C3D CAD  sing N N 209 
HEM C4D ND   sing N N 210 
HEM CMD HMD  sing N N 211 
HEM CMD HMDA sing N N 212 
HEM CMD HMDB sing N N 213 
HEM CAD CBD  sing N N 214 
HEM CAD HAD  sing N N 215 
HEM CAD HADA sing N N 216 
HEM CBD CGD  sing N N 217 
HEM CBD HBD  sing N N 218 
HEM CBD HBDA sing N N 219 
HEM CGD O1D  doub N N 220 
HEM CGD O2D  sing N N 221 
HEM O2A H2A  sing N N 222 
HEM O2D H2D  sing N N 223 
HEM FE  NA   sing N N 224 
HEM FE  NB   sing N N 225 
HEM FE  NC   sing N N 226 
HEM FE  ND   sing N N 227 
HIS N   CA   sing N N 228 
HIS N   H    sing N N 229 
HIS N   H2   sing N N 230 
HIS CA  C    sing N N 231 
HIS CA  CB   sing N N 232 
HIS CA  HA   sing N N 233 
HIS C   O    doub N N 234 
HIS C   OXT  sing N N 235 
HIS CB  CG   sing N N 236 
HIS CB  HB2  sing N N 237 
HIS CB  HB3  sing N N 238 
HIS CG  ND1  sing Y N 239 
HIS CG  CD2  doub Y N 240 
HIS ND1 CE1  doub Y N 241 
HIS ND1 HD1  sing N N 242 
HIS CD2 NE2  sing Y N 243 
HIS CD2 HD2  sing N N 244 
HIS CE1 NE2  sing Y N 245 
HIS CE1 HE1  sing N N 246 
HIS NE2 HE2  sing N N 247 
HIS OXT HXT  sing N N 248 
HOH O   H1   sing N N 249 
HOH O   H2   sing N N 250 
ILE N   CA   sing N N 251 
ILE N   H    sing N N 252 
ILE N   H2   sing N N 253 
ILE CA  C    sing N N 254 
ILE CA  CB   sing N N 255 
ILE CA  HA   sing N N 256 
ILE C   O    doub N N 257 
ILE C   OXT  sing N N 258 
ILE CB  CG1  sing N N 259 
ILE CB  CG2  sing N N 260 
ILE CB  HB   sing N N 261 
ILE CG1 CD1  sing N N 262 
ILE CG1 HG12 sing N N 263 
ILE CG1 HG13 sing N N 264 
ILE CG2 HG21 sing N N 265 
ILE CG2 HG22 sing N N 266 
ILE CG2 HG23 sing N N 267 
ILE CD1 HD11 sing N N 268 
ILE CD1 HD12 sing N N 269 
ILE CD1 HD13 sing N N 270 
ILE OXT HXT  sing N N 271 
LEU N   CA   sing N N 272 
LEU N   H    sing N N 273 
LEU N   H2   sing N N 274 
LEU CA  C    sing N N 275 
LEU CA  CB   sing N N 276 
LEU CA  HA   sing N N 277 
LEU C   O    doub N N 278 
LEU C   OXT  sing N N 279 
LEU CB  CG   sing N N 280 
LEU CB  HB2  sing N N 281 
LEU CB  HB3  sing N N 282 
LEU CG  CD1  sing N N 283 
LEU CG  CD2  sing N N 284 
LEU CG  HG   sing N N 285 
LEU CD1 HD11 sing N N 286 
LEU CD1 HD12 sing N N 287 
LEU CD1 HD13 sing N N 288 
LEU CD2 HD21 sing N N 289 
LEU CD2 HD22 sing N N 290 
LEU CD2 HD23 sing N N 291 
LEU OXT HXT  sing N N 292 
LYS N   CA   sing N N 293 
LYS N   H    sing N N 294 
LYS N   H2   sing N N 295 
LYS CA  C    sing N N 296 
LYS CA  CB   sing N N 297 
LYS CA  HA   sing N N 298 
LYS C   O    doub N N 299 
LYS C   OXT  sing N N 300 
LYS CB  CG   sing N N 301 
LYS CB  HB2  sing N N 302 
LYS CB  HB3  sing N N 303 
LYS CG  CD   sing N N 304 
LYS CG  HG2  sing N N 305 
LYS CG  HG3  sing N N 306 
LYS CD  CE   sing N N 307 
LYS CD  HD2  sing N N 308 
LYS CD  HD3  sing N N 309 
LYS CE  NZ   sing N N 310 
LYS CE  HE2  sing N N 311 
LYS CE  HE3  sing N N 312 
LYS NZ  HZ1  sing N N 313 
LYS NZ  HZ2  sing N N 314 
LYS NZ  HZ3  sing N N 315 
LYS OXT HXT  sing N N 316 
MET N   CA   sing N N 317 
MET N   H    sing N N 318 
MET N   H2   sing N N 319 
MET CA  C    sing N N 320 
MET CA  CB   sing N N 321 
MET CA  HA   sing N N 322 
MET C   O    doub N N 323 
MET C   OXT  sing N N 324 
MET CB  CG   sing N N 325 
MET CB  HB2  sing N N 326 
MET CB  HB3  sing N N 327 
MET CG  SD   sing N N 328 
MET CG  HG2  sing N N 329 
MET CG  HG3  sing N N 330 
MET SD  CE   sing N N 331 
MET CE  HE1  sing N N 332 
MET CE  HE2  sing N N 333 
MET CE  HE3  sing N N 334 
MET OXT HXT  sing N N 335 
PHE N   CA   sing N N 336 
PHE N   H    sing N N 337 
PHE N   H2   sing N N 338 
PHE CA  C    sing N N 339 
PHE CA  CB   sing N N 340 
PHE CA  HA   sing N N 341 
PHE C   O    doub N N 342 
PHE C   OXT  sing N N 343 
PHE CB  CG   sing N N 344 
PHE CB  HB2  sing N N 345 
PHE CB  HB3  sing N N 346 
PHE CG  CD1  doub Y N 347 
PHE CG  CD2  sing Y N 348 
PHE CD1 CE1  sing Y N 349 
PHE CD1 HD1  sing N N 350 
PHE CD2 CE2  doub Y N 351 
PHE CD2 HD2  sing N N 352 
PHE CE1 CZ   doub Y N 353 
PHE CE1 HE1  sing N N 354 
PHE CE2 CZ   sing Y N 355 
PHE CE2 HE2  sing N N 356 
PHE CZ  HZ   sing N N 357 
PHE OXT HXT  sing N N 358 
PRO N   CA   sing N N 359 
PRO N   CD   sing N N 360 
PRO N   H    sing N N 361 
PRO CA  C    sing N N 362 
PRO CA  CB   sing N N 363 
PRO CA  HA   sing N N 364 
PRO C   O    doub N N 365 
PRO C   OXT  sing N N 366 
PRO CB  CG   sing N N 367 
PRO CB  HB2  sing N N 368 
PRO CB  HB3  sing N N 369 
PRO CG  CD   sing N N 370 
PRO CG  HG2  sing N N 371 
PRO CG  HG3  sing N N 372 
PRO CD  HD2  sing N N 373 
PRO CD  HD3  sing N N 374 
PRO OXT HXT  sing N N 375 
SER N   CA   sing N N 376 
SER N   H    sing N N 377 
SER N   H2   sing N N 378 
SER CA  C    sing N N 379 
SER CA  CB   sing N N 380 
SER CA  HA   sing N N 381 
SER C   O    doub N N 382 
SER C   OXT  sing N N 383 
SER CB  OG   sing N N 384 
SER CB  HB2  sing N N 385 
SER CB  HB3  sing N N 386 
SER OG  HG   sing N N 387 
SER OXT HXT  sing N N 388 
THR N   CA   sing N N 389 
THR N   H    sing N N 390 
THR N   H2   sing N N 391 
THR CA  C    sing N N 392 
THR CA  CB   sing N N 393 
THR CA  HA   sing N N 394 
THR C   O    doub N N 395 
THR C   OXT  sing N N 396 
THR CB  OG1  sing N N 397 
THR CB  CG2  sing N N 398 
THR CB  HB   sing N N 399 
THR OG1 HG1  sing N N 400 
THR CG2 HG21 sing N N 401 
THR CG2 HG22 sing N N 402 
THR CG2 HG23 sing N N 403 
THR OXT HXT  sing N N 404 
TRP N   CA   sing N N 405 
TRP N   H    sing N N 406 
TRP N   H2   sing N N 407 
TRP CA  C    sing N N 408 
TRP CA  CB   sing N N 409 
TRP CA  HA   sing N N 410 
TRP C   O    doub N N 411 
TRP C   OXT  sing N N 412 
TRP CB  CG   sing N N 413 
TRP CB  HB2  sing N N 414 
TRP CB  HB3  sing N N 415 
TRP CG  CD1  doub Y N 416 
TRP CG  CD2  sing Y N 417 
TRP CD1 NE1  sing Y N 418 
TRP CD1 HD1  sing N N 419 
TRP CD2 CE2  doub Y N 420 
TRP CD2 CE3  sing Y N 421 
TRP NE1 CE2  sing Y N 422 
TRP NE1 HE1  sing N N 423 
TRP CE2 CZ2  sing Y N 424 
TRP CE3 CZ3  doub Y N 425 
TRP CE3 HE3  sing N N 426 
TRP CZ2 CH2  doub Y N 427 
TRP CZ2 HZ2  sing N N 428 
TRP CZ3 CH2  sing Y N 429 
TRP CZ3 HZ3  sing N N 430 
TRP CH2 HH2  sing N N 431 
TRP OXT HXT  sing N N 432 
TYR N   CA   sing N N 433 
TYR N   H    sing N N 434 
TYR N   H2   sing N N 435 
TYR CA  C    sing N N 436 
TYR CA  CB   sing N N 437 
TYR CA  HA   sing N N 438 
TYR C   O    doub N N 439 
TYR C   OXT  sing N N 440 
TYR CB  CG   sing N N 441 
TYR CB  HB2  sing N N 442 
TYR CB  HB3  sing N N 443 
TYR CG  CD1  doub Y N 444 
TYR CG  CD2  sing Y N 445 
TYR CD1 CE1  sing Y N 446 
TYR CD1 HD1  sing N N 447 
TYR CD2 CE2  doub Y N 448 
TYR CD2 HD2  sing N N 449 
TYR CE1 CZ   doub Y N 450 
TYR CE1 HE1  sing N N 451 
TYR CE2 CZ   sing Y N 452 
TYR CE2 HE2  sing N N 453 
TYR CZ  OH   sing N N 454 
TYR OH  HH   sing N N 455 
TYR OXT HXT  sing N N 456 
UYM C8  C9   doub Y N 457 
UYM C8  C7   sing Y N 458 
UYM C9  C10  sing Y N 459 
UYM C7  C6   doub Y N 460 
UYM C10 C5   doub Y N 461 
UYM C6  C5   sing Y N 462 
UYM C6  C3   sing Y N 463 
UYM C5  N    sing Y N 464 
UYM O   C    doub N N 465 
UYM C3  C2   sing N N 466 
UYM C3  C4   doub Y N 467 
UYM C1  C    sing N N 468 
UYM C1  C2   sing N N 469 
UYM C1  N1   sing N N 470 
UYM N   C4   sing Y N 471 
UYM C   N2   sing N N 472 
UYM N1  C15  sing N N 473 
UYM N2  C11  sing N N 474 
UYM C15 C11  sing N N 475 
UYM C15 O1   doub N N 476 
UYM C11 C12  sing N N 477 
UYM C35 C34  doub Y N 478 
UYM C35 N36  sing Y N 479 
UYM C12 C34  sing N N 480 
UYM C34 C38  sing Y N 481 
UYM N36 C37  sing Y N 482 
UYM C38 C37  doub Y N 483 
UYM C38 C39  sing Y N 484 
UYM C37 C42  sing Y N 485 
UYM C39 C40  doub Y N 486 
UYM C42 C41  doub Y N 487 
UYM C40 C41  sing Y N 488 
UYM N   H1   sing N N 489 
UYM C1  H2   sing N N 490 
UYM C10 H3   sing N N 491 
UYM C11 H4   sing N N 492 
UYM C12 H5   sing N N 493 
UYM C12 H6   sing N N 494 
UYM C2  H7   sing N N 495 
UYM C2  H8   sing N N 496 
UYM C35 H9   sing N N 497 
UYM C39 H10  sing N N 498 
UYM C4  H11  sing N N 499 
UYM C40 H12  sing N N 500 
UYM C41 H13  sing N N 501 
UYM C42 H14  sing N N 502 
UYM C7  H15  sing N N 503 
UYM C8  H16  sing N N 504 
UYM C9  H17  sing N N 505 
UYM N1  H18  sing N N 506 
UYM N2  H19  sing N N 507 
UYM N36 H20  sing N N 508 
VAL N   CA   sing N N 509 
VAL N   H    sing N N 510 
VAL N   H2   sing N N 511 
VAL CA  C    sing N N 512 
VAL CA  CB   sing N N 513 
VAL CA  HA   sing N N 514 
VAL C   O    doub N N 515 
VAL C   OXT  sing N N 516 
VAL CB  CG1  sing N N 517 
VAL CB  CG2  sing N N 518 
VAL CB  HB   sing N N 519 
VAL CG1 HG11 sing N N 520 
VAL CG1 HG12 sing N N 521 
VAL CG1 HG13 sing N N 522 
VAL CG2 HG21 sing N N 523 
VAL CG2 HG22 sing N N 524 
VAL CG2 HG23 sing N N 525 
VAL OXT HXT  sing N N 526 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           31800052 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8YZA 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011290 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011290 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007198 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
FE 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . PRO A 1 18  ? -10.774 1.609   -14.143 1.00 90.69  ?  18  PRO A N   1 
ATOM   2    C  CA  . PRO A 1 18  ? -10.764 0.962   -12.825 1.00 88.85  ?  18  PRO A CA  1 
ATOM   3    C  C   . PRO A 1 18  ? -10.136 -0.443  -12.854 1.00 85.20  ?  18  PRO A C   1 
ATOM   4    O  O   . PRO A 1 18  ? -9.881  -0.980  -13.936 1.00 82.45  ?  18  PRO A O   1 
ATOM   5    C  CB  . PRO A 1 18  ? -12.251 0.901   -12.463 1.00 86.96  ?  18  PRO A CB  1 
ATOM   6    C  CG  . PRO A 1 18  ? -12.964 0.845   -13.773 1.00 90.89  ?  18  PRO A CG  1 
ATOM   7    C  CD  . PRO A 1 18  ? -12.081 1.486   -14.817 1.00 90.23  ?  18  PRO A CD  1 
ATOM   8    N  N   . PRO A 1 19  ? -9.855  -1.014  -11.672 1.00 81.33  ?  19  PRO A N   1 
ATOM   9    C  CA  . PRO A 1 19  ? -9.270  -2.364  -11.623 1.00 73.46  ?  19  PRO A CA  1 
ATOM   10   C  C   . PRO A 1 19  ? -10.286 -3.436  -11.240 1.00 64.16  ?  19  PRO A C   1 
ATOM   11   O  O   . PRO A 1 19  ? -10.962 -3.320  -10.211 1.00 62.51  ?  19  PRO A O   1 
ATOM   12   C  CB  . PRO A 1 19  ? -8.174  -2.221  -10.558 1.00 74.83  ?  19  PRO A CB  1 
ATOM   13   C  CG  . PRO A 1 19  ? -8.602  -0.994  -9.703  1.00 79.24  ?  19  PRO A CG  1 
ATOM   14   C  CD  . PRO A 1 19  ? -9.816  -0.362  -10.350 1.00 79.85  ?  19  PRO A CD  1 
ATOM   15   N  N   . LEU A 1 20  ? -10.404 -4.483  -12.053 1.00 55.63  ?  20  LEU A N   1 
ATOM   16   C  CA  . LEU A 1 20  ? -11.422 -5.498  -11.816 1.00 48.15  ?  20  LEU A CA  1 
ATOM   17   C  C   . LEU A 1 20  ? -11.071 -6.345  -10.592 1.00 48.50  ?  20  LEU A C   1 
ATOM   18   O  O   . LEU A 1 20  ? -9.894  -6.560  -10.292 1.00 48.63  ?  20  LEU A O   1 
ATOM   19   C  CB  . LEU A 1 20  ? -11.564 -6.409  -13.033 1.00 47.89  ?  20  LEU A CB  1 
ATOM   20   C  CG  . LEU A 1 20  ? -12.009 -5.737  -14.335 1.00 50.02  ?  20  LEU A CG  1 
ATOM   21   C  CD1 . LEU A 1 20  ? -12.272 -6.764  -15.419 1.00 46.04  ?  20  LEU A CD1 1 
ATOM   22   C  CD2 . LEU A 1 20  ? -13.249 -4.878  -14.088 1.00 50.38  ?  20  LEU A CD2 1 
ATOM   23   N  N   . PRO A 1 21  ? -12.076 -6.841  -9.868  1.00 45.60  ?  21  PRO A N   1 
ATOM   24   C  CA  . PRO A 1 21  ? -11.805 -7.867  -8.847  1.00 46.20  ?  21  PRO A CA  1 
ATOM   25   C  C   . PRO A 1 21  ? -11.179 -9.100  -9.487  1.00 41.51  ?  21  PRO A C   1 
ATOM   26   O  O   . PRO A 1 21  ? -11.524 -9.480  -10.607 1.00 37.80  ?  21  PRO A O   1 
ATOM   27   C  CB  . PRO A 1 21  ? -13.191 -8.185  -8.271  1.00 44.10  ?  21  PRO A CB  1 
ATOM   28   C  CG  . PRO A 1 21  ? -14.086 -7.037  -8.694  1.00 45.64  ?  21  PRO A CG  1 
ATOM   29   C  CD  . PRO A 1 21  ? -13.506 -6.501  -9.971  1.00 45.74  ?  21  PRO A CD  1 
ATOM   30   N  N   . ASP A 1 22  ? -10.242 -9.719  -8.777  1.00 40.22  ?  22  ASP A N   1 
ATOM   31   C  CA  . ASP A 1 22  ? -9.656  -10.963 -9.261  1.00 39.71  ?  22  ASP A CA  1 
ATOM   32   C  C   . ASP A 1 22  ? -10.521 -12.162 -8.888  1.00 40.33  ?  22  ASP A C   1 
ATOM   33   O  O   . ASP A 1 22  ? -11.210 -12.166 -7.866  1.00 37.95  ?  22  ASP A O   1 
ATOM   34   C  CB  . ASP A 1 22  ? -8.246  -11.173 -8.699  1.00 43.39  ?  22  ASP A CB  1 
ATOM   35   C  CG  . ASP A 1 22  ? -7.265  -10.118 -9.169  1.00 45.32  ?  22  ASP A CG  1 
ATOM   36   O  OD1 . ASP A 1 22  ? -7.164  -9.899  -10.398 1.00 44.06  ?  22  ASP A OD1 1 
ATOM   37   O  OD2 . ASP A 1 22  ? -6.600  -9.515  -8.304  1.00 51.54  ?  22  ASP A OD2 1 
ATOM   38   N  N   . PHE A 1 23  ? -10.469 -13.187 -9.736  1.00 34.81  ?  23  PHE A N   1 
ATOM   39   C  CA  . PHE A 1 23  ? -11.066 -14.488 -9.501  1.00 35.72  ?  23  PHE A CA  1 
ATOM   40   C  C   . PHE A 1 23  ? -10.027 -15.542 -9.864  1.00 34.55  ?  23  PHE A C   1 
ATOM   41   O  O   . PHE A 1 23  ? -9.295  -15.363 -10.841 1.00 33.62  ?  23  PHE A O   1 
ATOM   42   C  CB  . PHE A 1 23  ? -12.359 -14.666 -10.337 1.00 35.36  ?  23  PHE A CB  1 
ATOM   43   C  CG  . PHE A 1 23  ? -13.207 -15.832 -9.892  1.00 32.75  ?  23  PHE A CG  1 
ATOM   44   C  CD1 . PHE A 1 23  ? -13.988 -15.741 -8.746  1.00 31.31  ?  23  PHE A CD1 1 
ATOM   45   C  CD2 . PHE A 1 23  ? -13.171 -17.025 -10.583 1.00 33.02  ?  23  PHE A CD2 1 
ATOM   46   C  CE1 . PHE A 1 23  ? -14.740 -16.835 -8.301  1.00 30.85  ?  23  PHE A CE1 1 
ATOM   47   C  CE2 . PHE A 1 23  ? -13.923 -18.125 -10.142 1.00 33.16  ?  23  PHE A CE2 1 
ATOM   48   C  CZ  . PHE A 1 23  ? -14.700 -18.023 -9.001  1.00 31.88  ?  23  PHE A CZ  1 
ATOM   49   N  N   . PRO A 1 24  ? -9.918  -16.645 -9.105  1.00 35.69  ?  24  PRO A N   1 
ATOM   50   C  CA  . PRO A 1 24  ? -10.773 -17.126 -8.011  1.00 34.47  ?  24  PRO A CA  1 
ATOM   51   C  C   . PRO A 1 24  ? -10.516 -16.425 -6.686  1.00 33.75  ?  24  PRO A C   1 
ATOM   52   O  O   . PRO A 1 24  ? -9.614  -15.606 -6.580  1.00 34.13  ?  24  PRO A O   1 
ATOM   53   C  CB  . PRO A 1 24  ? -10.403 -18.613 -7.914  1.00 31.62  ?  24  PRO A CB  1 
ATOM   54   C  CG  . PRO A 1 24  ? -8.942  -18.642 -8.301  1.00 33.36  ?  24  PRO A CG  1 
ATOM   55   C  CD  . PRO A 1 24  ? -8.794  -17.568 -9.371  1.00 34.37  ?  24  PRO A CD  1 
ATOM   56   N  N   . LEU A 1 25  ? -11.325 -16.763 -5.689  1.00 32.43  ?  25  LEU A N   1 
ATOM   57   C  CA  . LEU A 1 25  ? -11.211 -16.228 -4.344  1.00 32.32  ?  25  LEU A CA  1 
ATOM   58   C  C   . LEU A 1 25  ? -10.219 -17.064 -3.510  1.00 31.77  ?  25  LEU A C   1 
ATOM   59   O  O   . LEU A 1 25  ? -9.627  -18.035 -3.985  1.00 45.20  ?  25  LEU A O   1 
ATOM   60   C  CB  . LEU A 1 25  ? -12.601 -16.202 -3.701  1.00 32.42  ?  25  LEU A CB  1 
ATOM   61   C  CG  . LEU A 1 25  ? -13.685 -15.503 -4.546  1.00 33.85  ?  25  LEU A CG  1 
ATOM   62   C  CD1 . LEU A 1 25  ? -15.023 -15.452 -3.802  1.00 35.37  ?  25  LEU A CD1 1 
ATOM   63   C  CD2 . LEU A 1 25  ? -13.243 -14.104 -4.946  1.00 33.23  ?  25  LEU A CD2 1 
ATOM   64   N  N   . SER A 1 26  ? -10.063 -16.670 -2.241  1.00 30.52  ?  26  SER A N   1 
ATOM   65   C  CA  . SER A 1 26  ? -9.142  -17.307 -1.304  1.00 33.95  ?  26  SER A CA  1 
ATOM   66   C  C   . SER A 1 26  ? -9.264  -18.828 -1.331  1.00 30.37  ?  26  SER A C   1 
ATOM   67   O  O   . SER A 1 26  ? -10.365 -19.376 -1.435  1.00 25.88  ?  26  SER A O   1 
ATOM   68   C  CB  . SER A 1 26  ? -9.429  -16.802 0.118   1.00 34.00  ?  26  SER A CB  1 
ATOM   69   O  OG  . SER A 1 26  ? -8.745  -17.593 1.082   1.00 32.12  ?  26  SER A OG  1 
ATOM   70   N  N   . ARG A 1 27  ? -8.120  -19.507 -1.228  1.00 29.85  ?  27  ARG A N   1 
ATOM   71   C  CA  . ARG A 1 27  ? -8.075  -20.968 -1.140  1.00 29.27  ?  27  ARG A CA  1 
ATOM   72   C  C   . ARG A 1 27  ? -8.488  -21.497 0.222   1.00 28.69  ?  27  ARG A C   1 
ATOM   73   O  O   . ARG A 1 27  ? -8.703  -22.712 0.357   1.00 27.39  ?  27  ARG A O   1 
ATOM   74   C  CB  . ARG A 1 27  ? -6.660  -21.486 -1.466  1.00 31.96  ?  27  ARG A CB  1 
ATOM   75   C  CG  . ARG A 1 27  ? -6.139  -21.082 -2.853  1.00 35.24  ?  27  ARG A CG  1 
ATOM   76   C  CD  . ARG A 1 27  ? -6.977  -21.747 -3.973  1.00 35.72  ?  27  ARG A CD  1 
ATOM   77   N  NE  . ARG A 1 27  ? -8.178  -20.972 -4.259  1.00 33.64  ?  27  ARG A NE  1 
ATOM   78   C  CZ  . ARG A 1 27  ? -9.262  -21.449 -4.852  1.00 34.99  ?  27  ARG A CZ  1 
ATOM   79   N  NH1 . ARG A 1 27  ? -9.331  -22.705 -5.277  1.00 26.90  ?  27  ARG A NH1 1 
ATOM   80   N  NH2 . ARG A 1 27  ? -10.307 -20.647 -5.024  1.00 31.89  ?  27  ARG A NH2 1 
ATOM   81   N  N   . ARG A 1 28  ? -8.547  -20.636 1.233   1.00 26.81  ?  28  ARG A N   1 
ATOM   82   C  CA  . ARG A 1 28  ? -8.948  -21.059 2.566   1.00 31.37  ?  28  ARG A CA  1 
ATOM   83   C  C   . ARG A 1 28  ? -10.414 -21.490 2.575   1.00 31.69  ?  28  ARG A C   1 
ATOM   84   O  O   . ARG A 1 28  ? -11.293 -20.743 2.133   1.00 29.13  ?  28  ARG A O   1 
ATOM   85   C  CB  . ARG A 1 28  ? -8.718  -19.922 3.555   1.00 31.60  ?  28  ARG A CB  1 
ATOM   86   C  CG  . ARG A 1 28  ? -9.068  -20.293 4.990   1.00 36.45  ?  28  ARG A CG  1 
ATOM   87   C  CD  . ARG A 1 28  ? -8.914  -19.128 5.964   1.00 37.38  ?  28  ARG A CD  1 
ATOM   88   N  NE  . ARG A 1 28  ? -9.266  -19.562 7.310   1.00 38.60  ?  28  ARG A NE  1 
ATOM   89   C  CZ  . ARG A 1 28  ? -9.264  -18.785 8.384   1.00 44.06  ?  28  ARG A CZ  1 
ATOM   90   N  NH1 . ARG A 1 28  ? -8.912  -17.510 8.315   1.00 45.67  ?  28  ARG A NH1 1 
ATOM   91   N  NH2 . ARG A 1 28  ? -9.627  -19.302 9.558   1.00 43.68  ?  28  ARG A NH2 1 
ATOM   92   N  N   . GLY A 1 29  ? -10.684 -22.683 3.111   1.00 31.26  ?  29  GLY A N   1 
ATOM   93   C  CA  . GLY A 1 29  ? -12.005 -23.268 2.971   1.00 31.42  ?  29  GLY A CA  1 
ATOM   94   C  C   . GLY A 1 29  ? -12.822 -23.391 4.247   1.00 32.77  ?  29  GLY A C   1 
ATOM   95   O  O   . GLY A 1 29  ? -13.940 -23.908 4.207   1.00 32.17  ?  29  GLY A O   1 
ATOM   96   N  N   . ASP A 1 30  ? -12.310 -22.943 5.391   1.00 29.95  ?  30  ASP A N   1 
ATOM   97   C  CA  . ASP A 1 30  ? -13.081 -23.138 6.618   1.00 35.86  ?  30  ASP A CA  1 
ATOM   98   C  C   . ASP A 1 30  ? -13.948 -21.944 6.985   1.00 38.73  ?  30  ASP A C   1 
ATOM   99   O  O   . ASP A 1 30  ? -14.725 -22.049 7.940   1.00 37.04  ?  30  ASP A O   1 
ATOM   100  C  CB  . ASP A 1 30  ? -12.168 -23.467 7.808   1.00 34.13  ?  30  ASP A CB  1 
ATOM   101  C  CG  . ASP A 1 30  ? -11.192 -22.372 8.099   1.00 37.07  ?  30  ASP A CG  1 
ATOM   102  O  OD1 . ASP A 1 30  ? -10.319 -22.155 7.234   1.00 34.76  ?  30  ASP A OD1 1 
ATOM   103  O  OD2 . ASP A 1 30  ? -11.301 -21.731 9.180   1.00 36.36  ?  30  ASP A OD2 1 
ATOM   104  N  N   . ILE A 1 31  ? -13.829 -20.819 6.272   1.00 35.15  ?  31  ILE A N   1 
ATOM   105  C  CA  . ILE A 1 31  ? -14.703 -19.664 6.459   1.00 33.10  ?  31  ILE A CA  1 
ATOM   106  C  C   . ILE A 1 31  ? -14.998 -19.074 5.091   1.00 34.25  ?  31  ILE A C   1 
ATOM   107  O  O   . ILE A 1 31  ? -14.176 -19.148 4.173   1.00 31.07  ?  31  ILE A O   1 
ATOM   108  C  CB  . ILE A 1 31  ? -14.084 -18.571 7.366   1.00 40.12  ?  31  ILE A CB  1 
ATOM   109  C  CG1 . ILE A 1 31  ? -12.769 -18.064 6.758   1.00 36.86  ?  31  ILE A CG1 1 
ATOM   110  C  CG2 . ILE A 1 31  ? -13.851 -19.096 8.773   1.00 45.69  ?  31  ILE A CG2 1 
ATOM   111  C  CD1 . ILE A 1 31  ? -12.168 -16.855 7.475   1.00 50.88  ?  31  ILE A CD1 1 
ATOM   112  N  N   . LEU A 1 32  ? -16.185 -18.493 4.946   1.00 31.89  ?  32  LEU A N   1 
ATOM   113  C  CA  . LEU A 1 32  ? -16.533 -17.864 3.675   1.00 31.23  ?  32  LEU A CA  1 
ATOM   114  C  C   . LEU A 1 32  ? -15.532 -16.750 3.368   1.00 34.04  ?  32  LEU A C   1 
ATOM   115  O  O   . LEU A 1 32  ? -15.224 -15.952 4.258   1.00 34.19  ?  32  LEU A O   1 
ATOM   116  C  CB  . LEU A 1 32  ? -17.947 -17.283 3.741   1.00 30.69  ?  32  LEU A CB  1 
ATOM   117  C  CG  . LEU A 1 32  ? -18.439 -16.594 2.461   1.00 33.95  ?  32  LEU A CG  1 
ATOM   118  C  CD1 . LEU A 1 32  ? -18.741 -17.651 1.393   1.00 29.29  ?  32  LEU A CD1 1 
ATOM   119  C  CD2 . LEU A 1 32  ? -19.678 -15.755 2.790   1.00 32.46  ?  32  LEU A CD2 1 
ATOM   120  N  N   . PRO A 1 33  ? -15.009 -16.657 2.142   1.00 33.19  ?  33  PRO A N   1 
ATOM   121  C  CA  . PRO A 1 33  ? -14.165 -15.503 1.800   1.00 34.85  ?  33  PRO A CA  1 
ATOM   122  C  C   . PRO A 1 33  ? -14.936 -14.202 1.971   1.00 36.07  ?  33  PRO A C   1 
ATOM   123  O  O   . PRO A 1 33  ? -16.065 -14.068 1.497   1.00 32.54  ?  33  PRO A O   1 
ATOM   124  C  CB  . PRO A 1 33  ? -13.797 -15.748 0.330   1.00 34.98  ?  33  PRO A CB  1 
ATOM   125  C  CG  . PRO A 1 33  ? -13.979 -17.264 0.132   1.00 32.09  ?  33  PRO A CG  1 
ATOM   126  C  CD  . PRO A 1 33  ? -15.160 -17.591 1.007   1.00 32.63  ?  33  PRO A CD  1 
ATOM   127  N  N   . ALA A 1 34  ? -14.316 -13.244 2.668   1.00 37.16  ?  34  ALA A N   1 
ATOM   128  C  CA  . ALA A 1 34  ? -14.902 -11.911 2.817   1.00 40.47  ?  34  ALA A CA  1 
ATOM   129  C  C   . ALA A 1 34  ? -15.292 -11.319 1.469   1.00 40.37  ?  34  ALA A C   1 
ATOM   130  O  O   . ALA A 1 34  ? -16.320 -10.638 1.351   1.00 42.84  ?  34  ALA A O   1 
ATOM   131  C  CB  . ALA A 1 34  ? -13.917 -10.984 3.539   1.00 43.58  ?  34  ALA A CB  1 
ATOM   132  N  N   . GLU A 1 35  ? -14.492 -11.582 0.432   1.00 39.16  ?  35  GLU A N   1 
ATOM   133  C  CA  . GLU A 1 35  ? -14.801 -11.032 -0.884  1.00 39.34  ?  35  GLU A CA  1 
ATOM   134  C  C   . GLU A 1 35  ? -16.110 -11.589 -1.439  1.00 39.76  ?  35  GLU A C   1 
ATOM   135  O  O   . GLU A 1 35  ? -16.824 -10.889 -2.166  1.00 39.15  ?  35  GLU A O   1 
ATOM   136  C  CB  . GLU A 1 35  ? -13.643 -11.307 -1.843  1.00 38.98  ?  35  GLU A CB  1 
ATOM   137  C  CG  . GLU A 1 35  ? -13.879 -10.829 -3.261  1.00 40.67  ?  35  GLU A CG  1 
ATOM   138  C  CD  . GLU A 1 35  ? -13.773 -9.313  -3.447  1.00 46.20  ?  35  GLU A CD  1 
ATOM   139  O  OE1 . GLU A 1 35  ? -13.742 -8.550  -2.446  1.00 46.95  ?  35  GLU A OE1 1 
ATOM   140  O  OE2 . GLU A 1 35  ? -13.724 -8.888  -4.620  1.00 45.33  ?  35  GLU A OE2 1 
ATOM   141  N  N   . ALA A 1 36  ? -16.457 -12.834 -1.103  1.00 38.25  ?  36  ALA A N   1 
ATOM   142  C  CA  . ALA A 1 36  ? -17.712 -13.391 -1.599  1.00 38.40  ?  36  ALA A CA  1 
ATOM   143  C  C   . ALA A 1 36  ? -18.906 -12.638 -1.022  1.00 41.81  ?  36  ALA A C   1 
ATOM   144  O  O   . ALA A 1 36  ? -19.902 -12.405 -1.720  1.00 40.87  ?  36  ALA A O   1 
ATOM   145  C  CB  . ALA A 1 36  ? -17.797 -14.886 -1.266  1.00 36.49  ?  36  ALA A CB  1 
ATOM   146  N  N   . GLU A 1 37  ? -18.824 -12.248 0.250   1.00 39.90  ?  37  GLU A N   1 
ATOM   147  C  CA  . GLU A 1 37  ? -19.882 -11.431 0.840   1.00 38.92  ?  37  GLU A CA  1 
ATOM   148  C  C   . GLU A 1 37  ? -19.912 -10.029 0.234   1.00 42.72  ?  37  GLU A C   1 
ATOM   149  O  O   . GLU A 1 37  ? -20.991 -9.481  -0.015  1.00 45.88  ?  37  GLU A O   1 
ATOM   150  C  CB  . GLU A 1 37  ? -19.696 -11.374 2.355   1.00 41.76  ?  37  GLU A CB  1 
ATOM   151  C  CG  . GLU A 1 37  ? -20.875 -10.778 3.103   1.00 47.98  ?  37  GLU A CG  1 
ATOM   152  C  CD  . GLU A 1 37  ? -20.694 -10.814 4.619   1.00 55.67  ?  37  GLU A CD  1 
ATOM   153  O  OE1 . GLU A 1 37  ? -21.540 -10.227 5.337   1.00 59.04  ?  37  GLU A OE1 1 
ATOM   154  O  OE2 . GLU A 1 37  ? -19.737 -11.467 5.094   1.00 54.77  ?  37  GLU A OE2 1 
ATOM   155  N  N   . ARG A 1 38  ? -18.745 -9.433  -0.023  1.00 42.98  ?  38  ARG A N   1 
ATOM   156  C  CA  . ARG A 1 38  ? -18.728 -8.092  -0.607  1.00 41.26  ?  38  ARG A CA  1 
ATOM   157  C  C   . ARG A 1 38  ? -19.277 -8.101  -2.027  1.00 44.54  ?  38  ARG A C   1 
ATOM   158  O  O   . ARG A 1 38  ? -20.068 -7.223  -2.398  1.00 45.93  ?  38  ARG A O   1 
ATOM   159  C  CB  . ARG A 1 38  ? -17.311 -7.514  -0.601  1.00 43.25  ?  38  ARG A CB  1 
ATOM   160  C  CG  . ARG A 1 38  ? -17.252 -6.030  -1.024  1.00 46.27  ?  38  ARG A CG  1 
ATOM   161  C  CD  . ARG A 1 38  ? -15.878 -5.644  -1.583  1.00 45.18  ?  38  ARG A CD  1 
ATOM   162  N  NE  . ARG A 1 38  ? -15.541 -6.353  -2.815  1.00 44.74  ?  38  ARG A NE  1 
ATOM   163  C  CZ  . ARG A 1 38  ? -16.046 -6.067  -4.009  1.00 46.90  ?  38  ARG A CZ  1 
ATOM   164  N  NH1 . ARG A 1 38  ? -16.930 -5.095  -4.174  1.00 46.34  ?  38  ARG A NH1 1 
ATOM   165  N  NH2 . ARG A 1 38  ? -15.644 -6.764  -5.069  1.00 45.31  ?  38  ARG A NH2 1 
ATOM   166  N  N   . LEU A 1 39  ? -18.871 -9.083  -2.839  1.00 40.08  ?  39  LEU A N   1 
ATOM   167  C  CA  . LEU A 1 39  ? -19.400 -9.171  -4.197  1.00 41.68  ?  39  LEU A CA  1 
ATOM   168  C  C   . LEU A 1 39  ? -20.918 -9.291  -4.178  1.00 43.72  ?  39  LEU A C   1 
ATOM   169  O  O   . LEU A 1 39  ? -21.618 -8.588  -4.915  1.00 45.07  ?  39  LEU A O   1 
ATOM   170  C  CB  . LEU A 1 39  ? -18.772 -10.351 -4.950  1.00 40.04  ?  39  LEU A CB  1 
ATOM   171  C  CG  . LEU A 1 39  ? -17.289 -10.244 -5.305  1.00 43.87  ?  39  LEU A CG  1 
ATOM   172  C  CD1 . LEU A 1 39  ? -16.688 -11.650 -5.491  1.00 39.32  ?  39  LEU A CD1 1 
ATOM   173  C  CD2 . LEU A 1 39  ? -17.053 -9.386  -6.545  1.00 43.96  ?  39  LEU A CD2 1 
ATOM   174  N  N   . ARG A 1 40  ? -21.454 -10.165 -3.326  1.00 41.29  ?  40  ARG A N   1 
ATOM   175  C  CA  . ARG A 1 40  ? -22.898 -10.371 -3.342  1.00 43.36  ?  40  ARG A CA  1 
ATOM   176  C  C   . ARG A 1 40  ? -23.637 -9.108  -2.920  1.00 45.50  ?  40  ARG A C   1 
ATOM   177  O  O   . ARG A 1 40  ? -24.692 -8.783  -3.475  1.00 47.61  ?  40  ARG A O   1 
ATOM   178  C  CB  . ARG A 1 40  ? -23.293 -11.537 -2.441  1.00 40.89  ?  40  ARG A CB  1 
ATOM   179  C  CG  . ARG A 1 40  ? -24.793 -11.823 -2.471  1.00 42.40  ?  40  ARG A CG  1 
ATOM   180  C  CD  . ARG A 1 40  ? -25.161 -12.859 -1.435  1.00 41.88  ?  40  ARG A CD  1 
ATOM   181  N  NE  . ARG A 1 40  ? -24.698 -12.442 -0.119  1.00 44.52  ?  40  ARG A NE  1 
ATOM   182  C  CZ  . ARG A 1 40  ? -23.858 -13.139 0.632   1.00 47.11  ?  40  ARG A CZ  1 
ATOM   183  N  NH1 . ARG A 1 40  ? -23.400 -14.331 0.246   1.00 38.68  ?  40  ARG A NH1 1 
ATOM   184  N  NH2 . ARG A 1 40  ? -23.462 -12.631 1.797   1.00 50.31  ?  40  ARG A NH2 1 
ATOM   185  N  N   . ALA A 1 41  ? -23.094 -8.381  -1.944  1.00 46.27  ?  41  ALA A N   1 
ATOM   186  C  CA  . ALA A 1 41  ? -23.784 -7.203  -1.424  1.00 48.55  ?  41  ALA A CA  1 
ATOM   187  C  C   . ALA A 1 41  ? -23.654 -6.005  -2.357  1.00 49.64  ?  41  ALA A C   1 
ATOM   188  O  O   . ALA A 1 41  ? -24.591 -5.211  -2.482  1.00 52.51  ?  41  ALA A O   1 
ATOM   189  C  CB  . ALA A 1 41  ? -23.246 -6.849  -0.037  1.00 47.54  ?  41  ALA A CB  1 
ATOM   190  N  N   . GLU A 1 42  ? -22.513 -5.856  -3.025  1.00 45.35  ?  42  GLU A N   1 
ATOM   191  C  CA  . GLU A 1 42  ? -22.235 -4.637  -3.773  1.00 47.01  ?  42  GLU A CA  1 
ATOM   192  C  C   . GLU A 1 42  ? -22.410 -4.788  -5.276  1.00 49.87  ?  42  GLU A C   1 
ATOM   193  O  O   . GLU A 1 42  ? -22.829 -3.832  -5.937  1.00 42.01  ?  42  GLU A O   1 
ATOM   194  C  CB  . GLU A 1 42  ? -20.812 -4.150  -3.480  1.00 48.73  ?  42  GLU A CB  1 
ATOM   195  C  CG  . GLU A 1 42  ? -20.616 -3.759  -2.017  1.00 49.34  ?  42  GLU A CG  1 
ATOM   196  C  CD  . GLU A 1 42  ? -19.216 -3.260  -1.722  1.00 50.56  ?  42  GLU A CD  1 
ATOM   197  O  OE1 . GLU A 1 42  ? -18.384 -3.216  -2.658  1.00 52.60  ?  42  GLU A OE1 1 
ATOM   198  O  OE2 . GLU A 1 42  ? -18.943 -2.921  -0.548  1.00 52.68  ?  42  GLU A OE2 1 
ATOM   199  N  N   . GLN A 1 43  ? -22.108 -5.958  -5.843  1.00 44.25  ?  43  GLN A N   1 
ATOM   200  C  CA  . GLN A 1 43  ? -22.217 -6.170  -7.287  1.00 42.04  ?  43  GLN A CA  1 
ATOM   201  C  C   . GLN A 1 43  ? -22.504 -7.634  -7.548  1.00 42.07  ?  43  GLN A C   1 
ATOM   202  O  O   . GLN A 1 43  ? -21.632 -8.394  -7.989  1.00 40.67  ?  43  GLN A O   1 
ATOM   203  C  CB  . GLN A 1 43  ? -20.942 -5.706  -8.003  1.00 43.51  ?  43  GLN A CB  1 
ATOM   204  C  CG  . GLN A 1 43  ? -20.719 -4.182  -7.943  1.00 48.11  ?  43  GLN A CG  1 
ATOM   205  C  CD  . GLN A 1 43  ? -19.410 -3.708  -8.592  1.00 48.16  ?  43  GLN A CD  1 
ATOM   206  O  OE1 . GLN A 1 43  ? -18.438 -4.466  -8.694  1.00 49.76  ?  43  GLN A OE1 1 
ATOM   207  N  NE2 . GLN A 1 43  ? -19.385 -2.452  -9.035  1.00 46.59  ?  43  GLN A NE2 1 
ATOM   208  N  N   . PRO A 1 44  ? -23.735 -8.092  -7.277  1.00 42.80  ?  44  PRO A N   1 
ATOM   209  C  CA  . PRO A 1 44  ? -24.042 -9.523  -7.420  1.00 38.55  ?  44  PRO A CA  1 
ATOM   210  C  C   . PRO A 1 44  ? -23.830 -10.037 -8.831  1.00 42.71  ?  44  PRO A C   1 
ATOM   211  O  O   . PRO A 1 44  ? -23.804 -11.259 -9.030  1.00 38.74  ?  44  PRO A O   1 
ATOM   212  C  CB  . PRO A 1 44  ? -25.519 -9.611  -7.009  1.00 41.84  ?  44  PRO A CB  1 
ATOM   213  C  CG  . PRO A 1 44  ? -26.059 -8.203  -7.212  1.00 44.34  ?  44  PRO A CG  1 
ATOM   214  C  CD  . PRO A 1 44  ? -24.918 -7.304  -6.857  1.00 41.76  ?  44  PRO A CD  1 
ATOM   215  N  N   . VAL A 1 45  ? -23.725 -9.149  -9.822  1.00 40.41  ?  45  VAL A N   1 
ATOM   216  C  CA  . VAL A 1 45  ? -23.222 -9.492  -11.146 1.00 38.72  ?  45  VAL A CA  1 
ATOM   217  C  C   . VAL A 1 45  ? -22.052 -8.556  -11.386 1.00 42.89  ?  45  VAL A C   1 
ATOM   218  O  O   . VAL A 1 45  ? -22.240 -7.336  -11.506 1.00 40.99  ?  45  VAL A O   1 
ATOM   219  C  CB  . VAL A 1 45  ? -24.289 -9.360  -12.240 1.00 39.99  ?  45  VAL A CB  1 
ATOM   220  C  CG1 . VAL A 1 45  ? -23.796 -9.992  -13.513 1.00 41.74  ?  45  VAL A CG1 1 
ATOM   221  C  CG2 . VAL A 1 45  ? -25.575 -10.031 -11.807 1.00 39.83  ?  45  VAL A CG2 1 
ATOM   222  N  N   . ALA A 1 46  ? -20.840 -9.114  -11.422 1.00 38.91  ?  46  ALA A N   1 
ATOM   223  C  CA  . ALA A 1 46  ? -19.620 -8.321  -11.385 1.00 40.21  ?  46  ALA A CA  1 
ATOM   224  C  C   . ALA A 1 46  ? -18.658 -8.767  -12.475 1.00 42.35  ?  46  ALA A C   1 
ATOM   225  O  O   . ALA A 1 46  ? -18.438 -9.970  -12.680 1.00 39.19  ?  46  ALA A O   1 
ATOM   226  C  CB  . ALA A 1 46  ? -18.936 -8.431  -10.012 1.00 40.74  ?  46  ALA A CB  1 
ATOM   227  N  N   . ARG A 1 47  ? -18.082 -7.791  -13.169 1.00 38.72  ?  47  ARG A N   1 
ATOM   228  C  CA  . ARG A 1 47  ? -17.028 -8.071  -14.132 1.00 43.20  ?  47  ARG A CA  1 
ATOM   229  C  C   . ARG A 1 47  ? -15.760 -8.400  -13.352 1.00 41.24  ?  47  ARG A C   1 
ATOM   230  O  O   . ARG A 1 47  ? -15.326 -7.608  -12.511 1.00 37.23  ?  47  ARG A O   1 
ATOM   231  C  CB  . ARG A 1 47  ? -16.805 -6.870  -15.060 1.00 42.40  ?  47  ARG A CB  1 
ATOM   232  C  CG  . ARG A 1 47  ? -16.175 -7.219  -16.421 1.00 42.15  ?  47  ARG A CG  1 
ATOM   233  C  CD  . ARG A 1 47  ? -17.122 -8.088  -17.252 1.00 45.59  ?  47  ARG A CD  1 
ATOM   234  N  NE  . ARG A 1 47  ? -16.731 -8.211  -18.654 1.00 51.39  ?  47  ARG A NE  1 
ATOM   235  C  CZ  . ARG A 1 47  ? -16.994 -9.263  -19.427 1.00 54.39  ?  47  ARG A CZ  1 
ATOM   236  N  NH1 . ARG A 1 47  ? -17.617 -10.344 -18.955 1.00 46.58  ?  47  ARG A NH1 1 
ATOM   237  N  NH2 . ARG A 1 47  ? -16.620 -9.235  -20.706 1.00 58.42  ?  47  ARG A NH2 1 
ATOM   238  N  N   . VAL A 1 48  ? -15.177 -9.578  -13.600 1.00 40.67  ?  48  VAL A N   1 
ATOM   239  C  CA  . VAL A 1 48  ? -13.958 -9.970  -12.904 1.00 36.25  ?  48  VAL A CA  1 
ATOM   240  C  C   . VAL A 1 48  ? -12.903 -10.371 -13.925 1.00 36.02  ?  48  VAL A C   1 
ATOM   241  O  O   . VAL A 1 48  ? -13.200 -10.684 -15.078 1.00 38.87  ?  48  VAL A O   1 
ATOM   242  C  CB  . VAL A 1 48  ? -14.187 -11.132 -11.902 1.00 36.23  ?  48  VAL A CB  1 
ATOM   243  C  CG1 . VAL A 1 48  ? -15.219 -10.756 -10.854 1.00 35.68  ?  48  VAL A CG1 1 
ATOM   244  C  CG2 . VAL A 1 48  ? -14.569 -12.419 -12.644 1.00 34.05  ?  48  VAL A CG2 1 
ATOM   245  N  N   . ARG A 1 49  ? -11.654 -10.379 -13.472 1.00 33.93  ?  49  ARG A N   1 
ATOM   246  C  CA  . ARG A 1 49  ? -10.539 -10.890 -14.258 1.00 35.96  ?  49  ARG A CA  1 
ATOM   247  C  C   . ARG A 1 49  ? -10.174 -12.264 -13.713 1.00 34.16  ?  49  ARG A C   1 
ATOM   248  O  O   . ARG A 1 49  ? -9.787  -12.375 -12.550 1.00 34.96  ?  49  ARG A O   1 
ATOM   249  C  CB  . ARG A 1 49  ? -9.332  -9.954  -14.173 1.00 36.80  ?  49  ARG A CB  1 
ATOM   250  C  CG  . ARG A 1 49  ? -8.226  -10.246 -15.193 1.00 40.85  ?  49  ARG A CG  1 
ATOM   251  C  CD  . ARG A 1 49  ? -6.868  -9.803  -14.656 1.00 44.36  ?  49  ARG A CD  1 
ATOM   252  N  NE  . ARG A 1 49  ? -5.735  -10.320 -15.419 1.00 47.97  ?  49  ARG A NE  1 
ATOM   253  C  CZ  . ARG A 1 49  ? -4.888  -11.247 -14.986 1.00 49.59  ?  49  ARG A CZ  1 
ATOM   254  N  NH1 . ARG A 1 49  ? -5.061  -11.856 -13.821 1.00 46.49  ?  49  ARG A NH1 1 
ATOM   255  N  NH2 . ARG A 1 49  ? -3.849  -11.583 -15.749 1.00 51.82  ?  49  ARG A NH2 1 
ATOM   256  N  N   . THR A 1 50  ? -10.307 -13.298 -14.543 1.00 34.60  ?  50  THR A N   1 
ATOM   257  C  CA  . THR A 1 50  ? -9.954  -14.648 -14.123 1.00 34.32  ?  50  THR A CA  1 
ATOM   258  C  C   . THR A 1 50  ? -8.438  -14.858 -14.173 1.00 37.73  ?  50  THR A C   1 
ATOM   259  O  O   . THR A 1 50  ? -7.675  -14.024 -14.674 1.00 34.78  ?  50  THR A O   1 
ATOM   260  C  CB  . THR A 1 50  ? -10.650 -15.691 -15.003 1.00 33.31  ?  50  THR A CB  1 
ATOM   261  O  OG1 . THR A 1 50  ? -9.965  -15.789 -16.254 1.00 35.24  ?  50  THR A OG1 1 
ATOM   262  C  CG2 . THR A 1 50  ? -12.111 -15.316 -15.266 1.00 31.74  ?  50  THR A CG2 1 
ATOM   263  N  N   . MET A 1 51  ? -8.001  -16.020 -13.667 1.00 33.52  ?  51  MET A N   1 
ATOM   264  C  CA  . MET A 1 51  ? -6.574  -16.324 -13.622 1.00 36.05  ?  51  MET A CA  1 
ATOM   265  C  C   . MET A 1 51  ? -5.952  -16.402 -15.008 1.00 35.65  ?  51  MET A C   1 
ATOM   266  O  O   . MET A 1 51  ? -4.732  -16.288 -15.131 1.00 35.41  ?  51  MET A O   1 
ATOM   267  C  CB  . MET A 1 51  ? -6.340  -17.637 -12.853 1.00 30.93  ?  51  MET A CB  1 
ATOM   268  C  CG  . MET A 1 51  ? -6.440  -18.887 -13.710 1.00 35.15  ?  51  MET A CG  1 
ATOM   269  S  SD  . MET A 1 51  ? -6.020  -20.361 -12.754 1.00 33.29  ?  51  MET A SD  1 
ATOM   270  C  CE  . MET A 1 51  ? -7.027  -20.167 -11.292 1.00 30.67  ?  51  MET A CE  1 
ATOM   271  N  N   . THR A 1 52  ? -6.745  -16.603 -16.057 1.00 33.99  ?  52  THR A N   1 
ATOM   272  C  CA  . THR A 1 52  ? -6.173  -16.568 -17.399 1.00 34.51  ?  52  THR A CA  1 
ATOM   273  C  C   . THR A 1 52  ? -5.938  -15.153 -17.914 1.00 37.77  ?  52  THR A C   1 
ATOM   274  O  O   . THR A 1 52  ? -5.285  -14.993 -18.951 1.00 36.40  ?  52  THR A O   1 
ATOM   275  C  CB  . THR A 1 52  ? -7.089  -17.284 -18.394 1.00 37.34  ?  52  THR A CB  1 
ATOM   276  O  OG1 . THR A 1 52  ? -8.302  -16.523 -18.522 1.00 34.82  ?  52  THR A OG1 1 
ATOM   277  C  CG2 . THR A 1 52  ? -7.422  -18.670 -17.896 1.00 34.93  ?  52  THR A CG2 1 
ATOM   278  N  N   . GLY A 1 53  ? -6.452  -14.135 -17.230 1.00 38.28  ?  53  GLY A N   1 
ATOM   279  C  CA  . GLY A 1 53  ? -6.501  -12.798 -17.777 1.00 39.94  ?  53  GLY A CA  1 
ATOM   280  C  C   . GLY A 1 53  ? -7.770  -12.481 -18.540 1.00 42.14  ?  53  GLY A C   1 
ATOM   281  O  O   . GLY A 1 53  ? -8.000  -11.309 -18.871 1.00 43.26  ?  53  GLY A O   1 
ATOM   282  N  N   . ASP A 1 54  ? -8.592  -13.482 -18.836 1.00 38.55  ?  54  ASP A N   1 
ATOM   283  C  CA  . ASP A 1 54  ? -9.870  -13.261 -19.493 1.00 39.05  ?  54  ASP A CA  1 
ATOM   284  C  C   . ASP A 1 54  ? -10.843 -12.585 -18.532 1.00 41.19  ?  54  ASP A C   1 
ATOM   285  O  O   . ASP A 1 54  ? -10.696 -12.646 -17.311 1.00 42.42  ?  54  ASP A O   1 
ATOM   286  C  CB  . ASP A 1 54  ? -10.478 -14.591 -19.974 1.00 38.35  ?  54  ASP A CB  1 
ATOM   287  C  CG  . ASP A 1 54  ? -9.681  -15.236 -21.108 1.00 41.92  ?  54  ASP A CG  1 
ATOM   288  O  OD1 . ASP A 1 54  ? -8.916  -14.515 -21.780 1.00 47.79  ?  54  ASP A OD1 1 
ATOM   289  O  OD2 . ASP A 1 54  ? -9.823  -16.453 -21.346 1.00 41.24  ?  54  ASP A OD2 1 
ATOM   290  N  N   . GLU A 1 55  ? -11.871 -11.958 -19.089 1.00 39.53  ?  55  GLU A N   1 
ATOM   291  C  CA  . GLU A 1 55  ? -12.892 -11.339 -18.259 1.00 40.74  ?  55  GLU A CA  1 
ATOM   292  C  C   . GLU A 1 55  ? -14.143 -12.199 -18.216 1.00 38.07  ?  55  GLU A C   1 
ATOM   293  O  O   . GLU A 1 55  ? -14.411 -12.983 -19.130 1.00 36.86  ?  55  GLU A O   1 
ATOM   294  C  CB  . GLU A 1 55  ? -13.240 -9.941  -18.759 1.00 44.08  ?  55  GLU A CB  1 
ATOM   295  C  CG  . GLU A 1 55  ? -12.237 -8.910  -18.325 1.00 48.39  ?  55  GLU A CG  1 
ATOM   296  C  CD  . GLU A 1 55  ? -12.383 -7.601  -19.089 1.00 57.53  ?  55  GLU A CD  1 
ATOM   297  O  OE1 . GLU A 1 55  ? -13.473 -7.367  -19.660 1.00 56.03  ?  55  GLU A OE1 1 
ATOM   298  O  OE2 . GLU A 1 55  ? -11.413 -6.804  -19.082 1.00 60.03  ?  55  GLU A OE2 1 
ATOM   299  N  N   . ALA A 1 56  ? -14.902 -12.058 -17.129 1.00 37.19  ?  56  ALA A N   1 
ATOM   300  C  CA  . ALA A 1 56  ? -16.095 -12.867 -16.938 1.00 37.34  ?  56  ALA A CA  1 
ATOM   301  C  C   . ALA A 1 56  ? -17.098 -12.108 -16.082 1.00 37.60  ?  56  ALA A C   1 
ATOM   302  O  O   . ALA A 1 56  ? -16.750 -11.154 -15.382 1.00 37.75  ?  56  ALA A O   1 
ATOM   303  C  CB  . ALA A 1 56  ? -15.762 -14.214 -16.284 1.00 35.68  ?  56  ALA A CB  1 
ATOM   304  N  N   . TRP A 1 57  ? -18.355 -12.554 -16.147 1.00 35.95  ?  57  TRP A N   1 
ATOM   305  C  CA  . TRP A 1 57  ? -19.409 -12.084 -15.255 1.00 37.94  ?  57  TRP A CA  1 
ATOM   306  C  C   . TRP A 1 57  ? -19.545 -13.076 -14.098 1.00 35.63  ?  57  TRP A C   1 
ATOM   307  O  O   . TRP A 1 57  ? -19.980 -14.216 -14.293 1.00 36.91  ?  57  TRP A O   1 
ATOM   308  C  CB  . TRP A 1 57  ? -20.729 -11.927 -16.009 1.00 38.37  ?  57  TRP A CB  1 
ATOM   309  C  CG  . TRP A 1 57  ? -20.729 -10.769 -16.998 1.00 41.51  ?  57  TRP A CG  1 
ATOM   310  C  CD1 . TRP A 1 57  ? -20.798 -10.852 -18.370 1.00 43.05  ?  57  TRP A CD1 1 
ATOM   311  C  CD2 . TRP A 1 57  ? -20.652 -9.370  -16.686 1.00 40.94  ?  57  TRP A CD2 1 
ATOM   312  N  NE1 . TRP A 1 57  ? -20.770 -9.588  -18.923 1.00 42.39  ?  57  TRP A NE1 1 
ATOM   313  C  CE2 . TRP A 1 57  ? -20.684 -8.663  -17.913 1.00 43.49  ?  57  TRP A CE2 1 
ATOM   314  C  CE3 . TRP A 1 57  ? -20.570 -8.644  -15.491 1.00 39.29  ?  57  TRP A CE3 1 
ATOM   315  C  CZ2 . TRP A 1 57  ? -20.631 -7.270  -17.974 1.00 42.53  ?  57  TRP A CZ2 1 
ATOM   316  C  CZ3 . TRP A 1 57  ? -20.512 -7.259  -15.556 1.00 42.95  ?  57  TRP A CZ3 1 
ATOM   317  C  CH2 . TRP A 1 57  ? -20.537 -6.587  -16.791 1.00 42.32  ?  57  TRP A CH2 1 
ATOM   318  N  N   . LEU A 1 58  ? -19.199 -12.628 -12.897 1.00 31.37  ?  58  LEU A N   1 
ATOM   319  C  CA  . LEU A 1 58  ? -19.318 -13.432 -11.685 1.00 35.64  ?  58  LEU A CA  1 
ATOM   320  C  C   . LEU A 1 58  ? -20.651 -13.144 -11.010 1.00 35.09  ?  58  LEU A C   1 
ATOM   321  O  O   . LEU A 1 58  ? -20.946 -11.993 -10.679 1.00 36.99  ?  58  LEU A O   1 
ATOM   322  C  CB  . LEU A 1 58  ? -18.165 -13.140 -10.719 1.00 36.57  ?  58  LEU A CB  1 
ATOM   323  C  CG  . LEU A 1 58  ? -18.106 -14.056 -9.489  1.00 34.76  ?  58  LEU A CG  1 
ATOM   324  C  CD1 . LEU A 1 58  ? -17.980 -15.509 -9.910  1.00 33.62  ?  58  LEU A CD1 1 
ATOM   325  C  CD2 . LEU A 1 58  ? -16.969 -13.659 -8.550  1.00 33.86  ?  58  LEU A CD2 1 
ATOM   326  N  N   . VAL A 1 59  ? -21.433 -14.194 -10.781 1.00 35.49  ?  59  VAL A N   1 
ATOM   327  C  CA  . VAL A 1 59  ? -22.792 -14.098 -10.255 1.00 34.12  ?  59  VAL A CA  1 
ATOM   328  C  C   . VAL A 1 59  ? -22.812 -14.694 -8.857  1.00 34.59  ?  59  VAL A C   1 
ATOM   329  O  O   . VAL A 1 59  ? -22.577 -15.899 -8.691  1.00 35.56  ?  59  VAL A O   1 
ATOM   330  C  CB  . VAL A 1 59  ? -23.789 -14.835 -11.158 1.00 36.68  ?  59  VAL A CB  1 
ATOM   331  C  CG1 . VAL A 1 59  ? -25.202 -14.588 -10.678 1.00 33.72  ?  59  VAL A CG1 1 
ATOM   332  C  CG2 . VAL A 1 59  ? -23.607 -14.435 -12.640 1.00 35.59  ?  59  VAL A CG2 1 
ATOM   333  N  N   . SER A 1 60  ? -23.149 -13.880 -7.852  1.00 33.61  ?  60  SER A N   1 
ATOM   334  C  CA  . SER A 1 60  ? -22.948 -14.305 -6.474  1.00 34.56  ?  60  SER A CA  1 
ATOM   335  C  C   . SER A 1 60  ? -24.171 -14.208 -5.568  1.00 39.48  ?  60  SER A C   1 
ATOM   336  O  O   . SER A 1 60  ? -24.058 -14.554 -4.389  1.00 38.04  ?  60  SER A O   1 
ATOM   337  C  CB  . SER A 1 60  ? -21.790 -13.511 -5.842  1.00 37.24  ?  60  SER A CB  1 
ATOM   338  O  OG  . SER A 1 60  ? -21.983 -12.105 -5.959  1.00 41.15  ?  60  SER A OG  1 
ATOM   339  N  N   . SER A 1 61  ? -25.324 -13.746 -6.061  1.00 36.00  ?  61  SER A N   1 
ATOM   340  C  CA  . SER A 1 61  ? -26.553 -13.778 -5.285  1.00 32.75  ?  61  SER A CA  1 
ATOM   341  C  C   . SER A 1 61  ? -27.343 -15.034 -5.628  1.00 33.41  ?  61  SER A C   1 
ATOM   342  O  O   . SER A 1 61  ? -27.258 -15.554 -6.739  1.00 34.81  ?  61  SER A O   1 
ATOM   343  C  CB  . SER A 1 61  ? -27.396 -12.528 -5.556  1.00 37.50  ?  61  SER A CB  1 
ATOM   344  O  OG  . SER A 1 61  ? -28.077 -12.673 -6.794  1.00 36.32  ?  61  SER A OG  1 
ATOM   345  N  N   . TYR A 1 62  ? -28.111 -15.531 -4.654  1.00 33.63  ?  62  TYR A N   1 
ATOM   346  C  CA  . TYR A 1 62  ? -28.841 -16.777 -4.872  1.00 33.68  ?  62  TYR A CA  1 
ATOM   347  C  C   . TYR A 1 62  ? -29.824 -16.647 -6.028  1.00 35.83  ?  62  TYR A C   1 
ATOM   348  O  O   . TYR A 1 62  ? -29.921 -17.533 -6.889  1.00 34.28  ?  62  TYR A O   1 
ATOM   349  C  CB  . TYR A 1 62  ? -29.578 -17.186 -3.599  1.00 29.98  ?  62  TYR A CB  1 
ATOM   350  C  CG  . TYR A 1 62  ? -30.408 -18.438 -3.745  1.00 34.86  ?  62  TYR A CG  1 
ATOM   351  C  CD1 . TYR A 1 62  ? -31.694 -18.393 -4.271  1.00 34.70  ?  62  TYR A CD1 1 
ATOM   352  C  CD2 . TYR A 1 62  ? -29.905 -19.666 -3.357  1.00 33.60  ?  62  TYR A CD2 1 
ATOM   353  C  CE1 . TYR A 1 62  ? -32.448 -19.524 -4.408  1.00 35.97  ?  62  TYR A CE1 1 
ATOM   354  C  CE2 . TYR A 1 62  ? -30.665 -20.821 -3.487  1.00 36.80  ?  62  TYR A CE2 1 
ATOM   355  C  CZ  . TYR A 1 62  ? -31.941 -20.741 -4.016  1.00 40.10  ?  62  TYR A CZ  1 
ATOM   356  O  OH  . TYR A 1 62  ? -32.701 -21.882 -4.150  1.00 33.69  ?  62  TYR A OH  1 
ATOM   357  N  N   . GLU A 1 63  ? -30.592 -15.562 -6.036  1.00 39.30  ?  63  GLU A N   1 
ATOM   358  C  CA  . GLU A 1 63  ? -31.635 -15.402 -7.042  1.00 40.87  ?  63  GLU A CA  1 
ATOM   359  C  C   . GLU A 1 63  ? -31.045 -15.417 -8.444  1.00 32.21  ?  63  GLU A C   1 
ATOM   360  O  O   . GLU A 1 63  ? -31.543 -16.119 -9.328  1.00 37.84  ?  63  GLU A O   1 
ATOM   361  C  CB  . GLU A 1 63  ? -32.407 -14.101 -6.785  1.00 42.83  ?  63  GLU A CB  1 
ATOM   362  C  CG  . GLU A 1 63  ? -33.403 -13.744 -7.879  1.00 49.60  ?  63  GLU A CG  1 
ATOM   363  C  CD  . GLU A 1 63  ? -33.752 -12.258 -7.878  1.00 62.69  ?  63  GLU A CD  1 
ATOM   364  O  OE1 . GLU A 1 63  ? -34.359 -11.789 -8.871  1.00 68.82  ?  63  GLU A OE1 1 
ATOM   365  O  OE2 . GLU A 1 63  ? -33.425 -11.563 -6.884  1.00 59.08  ?  63  GLU A OE2 1 
ATOM   366  N  N   . LEU A 1 64  ? -29.963 -14.674 -8.659  1.00 34.68  ?  64  LEU A N   1 
ATOM   367  C  CA  . LEU A 1 64  ? -29.370 -14.612 -9.990  1.00 34.18  ?  64  LEU A CA  1 
ATOM   368  C  C   . LEU A 1 64  ? -28.582 -15.877 -10.324 1.00 36.93  ?  64  LEU A C   1 
ATOM   369  O  O   . LEU A 1 64  ? -28.565 -16.301 -11.484 1.00 35.95  ?  64  LEU A O   1 
ATOM   370  C  CB  . LEU A 1 64  ? -28.488 -13.369 -10.092 1.00 34.29  ?  64  LEU A CB  1 
ATOM   371  C  CG  . LEU A 1 64  ? -29.324 -12.105 -9.843  1.00 40.44  ?  64  LEU A CG  1 
ATOM   372  C  CD1 . LEU A 1 64  ? -28.506 -10.820 -10.011 1.00 39.27  ?  64  LEU A CD1 1 
ATOM   373  C  CD2 . LEU A 1 64  ? -30.552 -12.105 -10.748 1.00 44.03  ?  64  LEU A CD2 1 
ATOM   374  N  N   . ALA A 1 65  ? -27.962 -16.520 -9.330  1.00 34.50  ?  65  ALA A N   1 
ATOM   375  C  CA  . ALA A 1 65  ? -27.295 -17.792 -9.602  1.00 33.91  ?  65  ALA A CA  1 
ATOM   376  C  C   . ALA A 1 65  ? -28.295 -18.842 -10.067 1.00 32.11  ?  65  ALA A C   1 
ATOM   377  O  O   . ALA A 1 65  ? -28.078 -19.514 -11.081 1.00 34.40  ?  65  ALA A O   1 
ATOM   378  C  CB  . ALA A 1 65  ? -26.537 -18.267 -8.357  1.00 32.01  ?  65  ALA A CB  1 
ATOM   379  N  N   . LYS A 1 66  ? -29.402 -18.998 -9.331  1.00 35.52  ?  66  LYS A N   1 
ATOM   380  C  CA  . LYS A 1 66  ? -30.456 -19.932 -9.729  1.00 35.46  ?  66  LYS A CA  1 
ATOM   381  C  C   . LYS A 1 66  ? -30.954 -19.628 -11.142 1.00 39.85  ?  66  LYS A C   1 
ATOM   382  O  O   . LYS A 1 66  ? -31.129 -20.539 -11.963 1.00 37.59  ?  66  LYS A O   1 
ATOM   383  C  CB  . LYS A 1 66  ? -31.609 -19.856 -8.722  1.00 38.48  ?  66  LYS A CB  1 
ATOM   384  C  CG  . LYS A 1 66  ? -32.511 -21.082 -8.642  1.00 45.56  ?  66  LYS A CG  1 
ATOM   385  C  CD  . LYS A 1 66  ? -33.876 -20.694 -8.066  1.00 48.41  ?  66  LYS A CD  1 
ATOM   386  C  CE  . LYS A 1 66  ? -34.806 -21.896 -7.969  1.00 53.18  ?  66  LYS A CE  1 
ATOM   387  N  NZ  . LYS A 1 66  ? -34.123 -23.015 -7.258  1.00 59.16  ?  66  LYS A NZ  1 
ATOM   388  N  N   . GLN A 1 67  ? -31.159 -18.345 -11.444 1.00 37.56  ?  67  GLN A N   1 
ATOM   389  C  CA  . GLN A 1 67  ? -31.614 -17.939 -12.774 1.00 38.41  ?  67  GLN A CA  1 
ATOM   390  C  C   . GLN A 1 67  ? -30.676 -18.447 -13.862 1.00 39.22  ?  67  GLN A C   1 
ATOM   391  O  O   . GLN A 1 67  ? -31.119 -19.044 -14.853 1.00 36.03  ?  67  GLN A O   1 
ATOM   392  C  CB  . GLN A 1 67  ? -31.717 -16.422 -12.835 1.00 39.09  ?  67  GLN A CB  1 
ATOM   393  C  CG  . GLN A 1 67  ? -32.780 -15.908 -13.771 1.00 46.81  ?  67  GLN A CG  1 
ATOM   394  C  CD  . GLN A 1 67  ? -32.845 -14.397 -13.761 1.00 47.89  ?  67  GLN A CD  1 
ATOM   395  O  OE1 . GLN A 1 67  ? -32.850 -13.778 -12.698 1.00 53.09  ?  67  GLN A OE1 1 
ATOM   396  N  NE2 . GLN A 1 67  ? -32.892 -13.793 -14.943 1.00 53.09  ?  67  GLN A NE2 1 
ATOM   397  N  N   . VAL A 1 68  ? -29.366 -18.231 -13.684 1.00 38.38  ?  68  VAL A N   1 
ATOM   398  C  CA  . VAL A 1 68  ? -28.396 -18.652 -14.693 1.00 36.19  ?  68  VAL A CA  1 
ATOM   399  C  C   . VAL A 1 68  ? -28.448 -20.158 -14.873 1.00 36.36  ?  68  VAL A C   1 
ATOM   400  O  O   . VAL A 1 68  ? -28.533 -20.663 -16.000 1.00 38.60  ?  68  VAL A O   1 
ATOM   401  C  CB  . VAL A 1 68  ? -26.979 -18.184 -14.314 1.00 34.46  ?  68  VAL A CB  1 
ATOM   402  C  CG1 . VAL A 1 68  ? -25.935 -18.939 -15.130 1.00 32.88  ?  68  VAL A CG1 1 
ATOM   403  C  CG2 . VAL A 1 68  ? -26.847 -16.704 -14.516 1.00 34.78  ?  68  VAL A CG2 1 
ATOM   404  N  N   . LEU A 1 69  ? -28.411 -20.901 -13.757 1.00 33.93  ?  69  LEU A N   1 
ATOM   405  C  CA  . LEU A 1 69  ? -28.411 -22.359 -13.840 1.00 36.90  ?  69  LEU A CA  1 
ATOM   406  C  C   . LEU A 1 69  ? -29.658 -22.879 -14.541 1.00 36.55  ?  69  LEU A C   1 
ATOM   407  O  O   . LEU A 1 69  ? -29.601 -23.889 -15.246 1.00 35.76  ?  69  LEU A O   1 
ATOM   408  C  CB  . LEU A 1 69  ? -28.291 -22.970 -12.435 1.00 34.32  ?  69  LEU A CB  1 
ATOM   409  C  CG  . LEU A 1 69  ? -26.979 -22.613 -11.705 1.00 36.85  ?  69  LEU A CG  1 
ATOM   410  C  CD1 . LEU A 1 69  ? -26.921 -23.227 -10.302 1.00 33.45  ?  69  LEU A CD1 1 
ATOM   411  C  CD2 . LEU A 1 69  ? -25.799 -23.058 -12.520 1.00 31.95  ?  69  LEU A CD2 1 
ATOM   412  N  N   . GLU A 1 70  ? -30.787 -22.204 -14.374 1.00 38.82  ?  70  GLU A N   1 
ATOM   413  C  CA  . GLU A 1 70  ? -32.046 -22.675 -14.938 1.00 38.83  ?  70  GLU A CA  1 
ATOM   414  C  C   . GLU A 1 70  ? -32.335 -22.131 -16.335 1.00 41.70  ?  70  GLU A C   1 
ATOM   415  O  O   . GLU A 1 70  ? -33.362 -22.484 -16.918 1.00 41.53  ?  70  GLU A O   1 
ATOM   416  C  CB  . GLU A 1 70  ? -33.186 -22.323 -13.985 1.00 41.09  ?  70  GLU A CB  1 
ATOM   417  C  CG  . GLU A 1 70  ? -33.254 -23.292 -12.798 1.00 41.34  ?  70  GLU A CG  1 
ATOM   418  C  CD  . GLU A 1 70  ? -34.136 -22.779 -11.676 1.00 48.84  ?  70  GLU A CD  1 
ATOM   419  O  OE1 . GLU A 1 70  ? -34.670 -21.651 -11.797 1.00 49.73  ?  70  GLU A OE1 1 
ATOM   420  O  OE2 . GLU A 1 70  ? -34.306 -23.511 -10.679 1.00 50.04  ?  70  GLU A OE2 1 
ATOM   421  N  N   . ASP A 1 71  ? -31.461 -21.297 -16.888 1.00 40.71  ?  71  ASP A N   1 
ATOM   422  C  CA  . ASP A 1 71  ? -31.665 -20.676 -18.197 1.00 40.68  ?  71  ASP A CA  1 
ATOM   423  C  C   . ASP A 1 71  ? -30.649 -21.268 -19.163 1.00 41.55  ?  71  ASP A C   1 
ATOM   424  O  O   . ASP A 1 71  ? -29.457 -20.953 -19.087 1.00 42.20  ?  71  ASP A O   1 
ATOM   425  C  CB  . ASP A 1 71  ? -31.529 -19.156 -18.098 1.00 38.90  ?  71  ASP A CB  1 
ATOM   426  C  CG  . ASP A 1 71  ? -31.732 -18.442 -19.441 1.00 41.85  ?  71  ASP A CG  1 
ATOM   427  O  OD1 . ASP A 1 71  ? -31.867 -19.110 -20.491 1.00 45.88  ?  71  ASP A OD1 1 
ATOM   428  O  OD2 . ASP A 1 71  ? -31.738 -17.194 -19.446 1.00 42.82  ?  71  ASP A OD2 1 
ATOM   429  N  N   . ASP A 1 72  ? -31.129 -22.099 -20.087 1.00 39.86  ?  72  ASP A N   1 
ATOM   430  C  CA  . ASP A 1 72  ? -30.269 -22.845 -20.996 1.00 41.63  ?  72  ASP A CA  1 
ATOM   431  C  C   . ASP A 1 72  ? -29.617 -21.978 -22.067 1.00 41.74  ?  72  ASP A C   1 
ATOM   432  O  O   . ASP A 1 72  ? -28.800 -22.499 -22.837 1.00 44.20  ?  72  ASP A O   1 
ATOM   433  C  CB  . ASP A 1 72  ? -31.061 -23.980 -21.641 1.00 44.83  ?  72  ASP A CB  1 
ATOM   434  C  CG  . ASP A 1 72  ? -31.316 -25.119 -20.675 1.00 51.85  ?  72  ASP A CG  1 
ATOM   435  O  OD1 . ASP A 1 72  ? -30.474 -25.310 -19.764 1.00 51.23  ?  72  ASP A OD1 1 
ATOM   436  O  OD2 . ASP A 1 72  ? -32.340 -25.823 -20.813 1.00 55.32  ?  72  ASP A OD2 1 
ATOM   437  N  N   . ARG A 1 73  ? -29.929 -20.684 -22.135 1.00 39.03  ?  73  ARG A N   1 
ATOM   438  C  CA  . ARG A 1 73  ? -29.127 -19.794 -22.965 1.00 40.94  ?  73  ARG A CA  1 
ATOM   439  C  C   . ARG A 1 73  ? -27.737 -19.572 -22.401 1.00 40.70  ?  73  ARG A C   1 
ATOM   440  O  O   . ARG A 1 73  ? -26.872 -19.048 -23.112 1.00 40.66  ?  73  ARG A O   1 
ATOM   441  C  CB  . ARG A 1 73  ? -29.818 -18.446 -23.132 1.00 40.56  ?  73  ARG A CB  1 
ATOM   442  C  CG  . ARG A 1 73  ? -31.166 -18.574 -23.838 1.00 44.96  ?  73  ARG A CG  1 
ATOM   443  C  CD  . ARG A 1 73  ? -31.848 -17.241 -23.878 1.00 44.42  ?  73  ARG A CD  1 
ATOM   444  N  NE  . ARG A 1 73  ? -32.382 -16.924 -22.565 1.00 43.48  ?  73  ARG A NE  1 
ATOM   445  C  CZ  . ARG A 1 73  ? -32.950 -15.772 -22.245 1.00 49.01  ?  73  ARG A CZ  1 
ATOM   446  N  NH1 . ARG A 1 73  ? -33.161 -14.832 -23.155 1.00 50.12  ?  73  ARG A NH1 1 
ATOM   447  N  NH2 . ARG A 1 73  ? -33.316 -15.559 -20.982 1.00 44.72  ?  73  ARG A NH2 1 
ATOM   448  N  N   . PHE A 1 74  ? -27.505 -19.921 -21.143 1.00 41.10  ?  74  PHE A N   1 
ATOM   449  C  CA  . PHE A 1 74  ? -26.154 -19.982 -20.596 1.00 38.80  ?  74  PHE A CA  1 
ATOM   450  C  C   . PHE A 1 74  ? -25.709 -21.437 -20.705 1.00 36.94  ?  74  PHE A C   1 
ATOM   451  O  O   . PHE A 1 74  ? -26.251 -22.310 -20.022 1.00 39.61  ?  74  PHE A O   1 
ATOM   452  C  CB  . PHE A 1 74  ? -26.124 -19.467 -19.160 1.00 38.91  ?  74  PHE A CB  1 
ATOM   453  C  CG  . PHE A 1 74  ? -26.637 -18.054 -18.999 1.00 39.51  ?  74  PHE A CG  1 
ATOM   454  C  CD1 . PHE A 1 74  ? -25.855 -16.966 -19.346 1.00 39.78  ?  74  PHE A CD1 1 
ATOM   455  C  CD2 . PHE A 1 74  ? -27.900 -17.815 -18.465 1.00 43.54  ?  74  PHE A CD2 1 
ATOM   456  C  CE1 . PHE A 1 74  ? -26.323 -15.663 -19.184 1.00 41.49  ?  74  PHE A CE1 1 
ATOM   457  C  CE2 . PHE A 1 74  ? -28.372 -16.510 -18.299 1.00 41.85  ?  74  PHE A CE2 1 
ATOM   458  C  CZ  . PHE A 1 74  ? -27.582 -15.438 -18.660 1.00 42.45  ?  74  PHE A CZ  1 
ATOM   459  N  N   . SER A 1 75  ? -24.725 -21.692 -21.564 1.00 36.23  ?  75  SER A N   1 
ATOM   460  C  CA  . SER A 1 75  ? -24.357 -23.034 -21.991 1.00 37.28  ?  75  SER A CA  1 
ATOM   461  C  C   . SER A 1 75  ? -23.095 -23.519 -21.281 1.00 35.73  ?  75  SER A C   1 
ATOM   462  O  O   . SER A 1 75  ? -22.060 -22.858 -21.334 1.00 36.20  ?  75  SER A O   1 
ATOM   463  C  CB  . SER A 1 75  ? -24.127 -23.045 -23.499 1.00 37.55  ?  75  SER A CB  1 
ATOM   464  O  OG  . SER A 1 75  ? -23.625 -24.286 -23.935 1.00 38.01  ?  75  SER A OG  1 
ATOM   465  N  N   . LEU A 1 76  ? -23.178 -24.690 -20.650 1.00 37.99  ?  76  LEU A N   1 
ATOM   466  C  CA  . LEU A 1 76  ? -21.973 -25.321 -20.114 1.00 37.06  ?  76  LEU A CA  1 
ATOM   467  C  C   . LEU A 1 76  ? -21.144 -25.938 -21.236 1.00 37.54  ?  76  LEU A C   1 
ATOM   468  O  O   . LEU A 1 76  ? -19.927 -25.728 -21.314 1.00 34.58  ?  76  LEU A O   1 
ATOM   469  C  CB  . LEU A 1 76  ? -22.351 -26.378 -19.079 1.00 35.03  ?  76  LEU A CB  1 
ATOM   470  C  CG  . LEU A 1 76  ? -21.230 -27.325 -18.629 1.00 38.76  ?  76  LEU A CG  1 
ATOM   471  C  CD1 . LEU A 1 76  ? -20.106 -26.536 -17.999 1.00 33.85  ?  76  LEU A CD1 1 
ATOM   472  C  CD2 . LEU A 1 76  ? -21.753 -28.381 -17.666 1.00 35.37  ?  76  LEU A CD2 1 
ATOM   473  N  N   . LYS A 1 77  ? -21.802 -26.672 -22.136 1.00 37.11  ?  77  LYS A N   1 
ATOM   474  C  CA  . LYS A 1 77  ? -21.103 -27.363 -23.217 1.00 41.28  ?  77  LYS A CA  1 
ATOM   475  C  C   . LYS A 1 77  ? -20.173 -26.424 -23.975 1.00 40.94  ?  77  LYS A C   1 
ATOM   476  O  O   . LYS A 1 77  ? -19.047 -26.802 -24.325 1.00 41.64  ?  77  LYS A O   1 
ATOM   477  C  CB  . LYS A 1 77  ? -22.121 -28.002 -24.173 1.00 45.95  ?  77  LYS A CB  1 
ATOM   478  C  CG  . LYS A 1 77  ? -21.783 -27.847 -25.654 1.00 51.07  ?  77  LYS A CG  1 
ATOM   479  C  CD  . LYS A 1 77  ? -22.894 -28.371 -26.564 1.00 53.33  ?  77  LYS A CD  1 
ATOM   480  C  CE  . LYS A 1 77  ? -22.463 -28.318 -28.040 1.00 62.32  ?  77  LYS A CE  1 
ATOM   481  N  NZ  . LYS A 1 77  ? -22.363 -26.922 -28.592 1.00 63.81  ?  77  LYS A NZ  1 
ATOM   482  N  N   . ASP A 1 78  ? -20.605 -25.185 -24.205 1.00 38.87  ?  78  ASP A N   1 
ATOM   483  C  CA  . ASP A 1 78  ? -19.795 -24.268 -25.004 1.00 39.93  ?  78  ASP A CA  1 
ATOM   484  C  C   . ASP A 1 78  ? -18.625 -23.655 -24.242 1.00 40.50  ?  78  ASP A C   1 
ATOM   485  O  O   . ASP A 1 78  ? -17.781 -22.994 -24.870 1.00 36.06  ?  78  ASP A O   1 
ATOM   486  C  CB  . ASP A 1 78  ? -20.672 -23.159 -25.586 1.00 44.72  ?  78  ASP A CB  1 
ATOM   487  C  CG  . ASP A 1 78  ? -21.583 -23.673 -26.710 1.00 47.87  ?  78  ASP A CG  1 
ATOM   488  O  OD1 . ASP A 1 78  ? -22.656 -24.226 -26.401 1.00 50.36  ?  78  ASP A OD1 1 
ATOM   489  O  OD2 . ASP A 1 78  ? -21.212 -23.546 -27.893 1.00 50.23  ?  78  ASP A OD2 1 
ATOM   490  N  N   . THR A 1 79  ? -18.531 -23.854 -22.920 1.00 38.18  ?  79  THR A N   1 
ATOM   491  C  CA  . THR A 1 79  ? -17.367 -23.319 -22.204 1.00 36.81  ?  79  THR A CA  1 
ATOM   492  C  C   . THR A 1 79  ? -16.063 -23.960 -22.676 1.00 38.93  ?  79  THR A C   1 
ATOM   493  O  O   . THR A 1 79  ? -14.986 -23.379 -22.476 1.00 38.97  ?  79  THR A O   1 
ATOM   494  C  CB  . THR A 1 79  ? -17.504 -23.514 -20.689 1.00 36.54  ?  79  THR A CB  1 
ATOM   495  O  OG1 . THR A 1 79  ? -17.603 -24.912 -20.382 1.00 36.12  ?  79  THR A OG1 1 
ATOM   496  C  CG2 . THR A 1 79  ? -18.738 -22.788 -20.168 1.00 34.14  ?  79  THR A CG2 1 
ATOM   497  N  N   . ALA A 1 80  ? -16.146 -25.125 -23.309 1.00 35.06  ?  80  ALA A N   1 
ATOM   498  C  CA  . ALA A 1 80  ? -15.002 -25.846 -23.836 1.00 40.39  ?  80  ALA A CA  1 
ATOM   499  C  C   . ALA A 1 80  ? -14.638 -25.452 -25.264 1.00 43.05  ?  80  ALA A C   1 
ATOM   500  O  O   . ALA A 1 80  ? -13.662 -25.983 -25.794 1.00 42.04  ?  80  ALA A O   1 
ATOM   501  C  CB  . ALA A 1 80  ? -15.275 -27.353 -23.782 1.00 40.16  ?  80  ALA A CB  1 
ATOM   502  N  N   . ASN A 1 81  ? -15.388 -24.551 -25.901 1.00 44.50  ?  81  ASN A N   1 
ATOM   503  C  CA  . ASN A 1 81  ? -15.127 -24.236 -27.301 1.00 45.40  ?  81  ASN A CA  1 
ATOM   504  C  C   . ASN A 1 81  ? -13.802 -23.487 -27.457 1.00 48.35  ?  81  ASN A C   1 
ATOM   505  O  O   . ASN A 1 81  ? -13.399 -22.719 -26.576 1.00 48.00  ?  81  ASN A O   1 
ATOM   506  C  CB  . ASN A 1 81  ? -16.246 -23.382 -27.894 1.00 43.33  ?  81  ASN A CB  1 
ATOM   507  C  CG  . ASN A 1 81  ? -17.528 -24.151 -28.100 1.00 44.58  ?  81  ASN A CG  1 
ATOM   508  O  OD1 . ASN A 1 81  ? -17.591 -25.365 -27.895 1.00 47.44  ?  81  ASN A OD1 1 
ATOM   509  N  ND2 . ASN A 1 81  ? -18.563 -23.446 -28.534 1.00 43.79  ?  81  ASN A ND2 1 
ATOM   510  N  N   . PRO A 1 82  ? -13.114 -23.676 -28.583 1.00 51.27  ?  82  PRO A N   1 
ATOM   511  C  CA  . PRO A 1 82  ? -11.911 -22.881 -28.846 1.00 49.09  ?  82  PRO A CA  1 
ATOM   512  C  C   . PRO A 1 82  ? -12.254 -21.404 -28.953 1.00 48.63  ?  82  PRO A C   1 
ATOM   513  O  O   . PRO A 1 82  ? -13.273 -21.021 -29.532 1.00 52.43  ?  82  PRO A O   1 
ATOM   514  C  CB  . PRO A 1 82  ? -11.395 -23.436 -30.181 1.00 51.14  ?  82  PRO A CB  1 
ATOM   515  C  CG  . PRO A 1 82  ? -12.109 -24.722 -30.391 1.00 51.89  ?  82  PRO A CG  1 
ATOM   516  C  CD  . PRO A 1 82  ? -13.409 -24.628 -29.666 1.00 50.27  ?  82  PRO A CD  1 
ATOM   517  N  N   . GLY A 1 83  ? -11.397 -20.569 -28.382 1.00 46.40  ?  83  GLY A N   1 
ATOM   518  C  CA  . GLY A 1 83  ? -11.542 -19.139 -28.505 1.00 44.15  ?  83  GLY A CA  1 
ATOM   519  C  C   . GLY A 1 83  ? -12.407 -18.462 -27.457 1.00 44.75  ?  83  GLY A C   1 
ATOM   520  O  O   . GLY A 1 83  ? -12.341 -17.235 -27.330 1.00 46.16  ?  83  GLY A O   1 
ATOM   521  N  N   . VAL A 1 84  ? -13.221 -19.201 -26.705 1.00 45.96  ?  84  VAL A N   1 
ATOM   522  C  CA  . VAL A 1 84  ? -14.098 -18.557 -25.721 1.00 42.69  ?  84  VAL A CA  1 
ATOM   523  C  C   . VAL A 1 84  ? -13.268 -18.119 -24.521 1.00 40.14  ?  84  VAL A C   1 
ATOM   524  O  O   . VAL A 1 84  ? -12.177 -18.664 -24.289 1.00 41.91  ?  84  VAL A O   1 
ATOM   525  C  CB  . VAL A 1 84  ? -15.257 -19.479 -25.300 1.00 42.10  ?  84  VAL A CB  1 
ATOM   526  C  CG1 . VAL A 1 84  ? -16.052 -19.920 -26.522 1.00 43.18  ?  84  VAL A CG1 1 
ATOM   527  C  CG2 . VAL A 1 84  ? -14.744 -20.687 -24.505 1.00 39.46  ?  84  VAL A CG2 1 
ATOM   528  N  N   . PRO A 1 85  ? -13.707 -17.131 -23.749 1.00 41.43  ?  85  PRO A N   1 
ATOM   529  C  CA  . PRO A 1 85  ? -12.965 -16.794 -22.532 1.00 40.49  ?  85  PRO A CA  1 
ATOM   530  C  C   . PRO A 1 85  ? -13.118 -17.914 -21.513 1.00 38.11  ?  85  PRO A C   1 
ATOM   531  O  O   . PRO A 1 85  ? -14.110 -18.652 -21.509 1.00 34.04  ?  85  PRO A O   1 
ATOM   532  C  CB  . PRO A 1 85  ? -13.607 -15.485 -22.053 1.00 39.69  ?  85  PRO A CB  1 
ATOM   533  C  CG  . PRO A 1 85  ? -14.908 -15.362 -22.804 1.00 41.46  ?  85  PRO A CG  1 
ATOM   534  C  CD  . PRO A 1 85  ? -14.937 -16.331 -23.925 1.00 41.90  ?  85  PRO A CD  1 
ATOM   535  N  N   . ARG A 1 86  ? -12.094 -18.058 -20.670 1.00 37.99  ?  86  ARG A N   1 
ATOM   536  C  CA  . ARG A 1 86  ? -11.959 -19.177 -19.745 1.00 35.21  ?  86  ARG A CA  1 
ATOM   537  C  C   . ARG A 1 86  ? -11.604 -18.684 -18.350 1.00 34.18  ?  86  ARG A C   1 
ATOM   538  O  O   . ARG A 1 86  ? -10.857 -17.713 -18.195 1.00 33.66  ?  86  ARG A O   1 
ATOM   539  C  CB  . ARG A 1 86  ? -10.835 -20.150 -20.167 1.00 37.55  ?  86  ARG A CB  1 
ATOM   540  C  CG  . ARG A 1 86  ? -10.776 -20.537 -21.614 1.00 40.09  ?  86  ARG A CG  1 
ATOM   541  C  CD  . ARG A 1 86  ? -10.011 -21.845 -21.717 1.00 41.73  ?  86  ARG A CD  1 
ATOM   542  N  NE  . ARG A 1 86  ? -10.708 -22.868 -20.950 1.00 41.94  ?  86  ARG A NE  1 
ATOM   543  C  CZ  . ARG A 1 86  ? -11.784 -23.494 -21.392 1.00 43.63  ?  86  ARG A CZ  1 
ATOM   544  N  NH1 . ARG A 1 86  ? -12.221 -23.313 -22.628 1.00 43.92  ?  86  ARG A NH1 1 
ATOM   545  N  NH2 . ARG A 1 86  ? -12.438 -24.320 -20.580 1.00 37.83  ?  86  ARG A NH2 1 
ATOM   546  N  N   . GLN A 1 87  ? -12.081 -19.410 -17.329 1.00 33.08  ?  87  GLN A N   1 
ATOM   547  C  CA  . GLN A 1 87  ? -11.576 -19.181 -15.981 1.00 31.76  ?  87  GLN A CA  1 
ATOM   548  C  C   . GLN A 1 87  ? -10.243 -19.897 -15.739 1.00 32.51  ?  87  GLN A C   1 
ATOM   549  O  O   . GLN A 1 87  ? -9.451  -19.449 -14.904 1.00 33.98  ?  87  GLN A O   1 
ATOM   550  C  CB  . GLN A 1 87  ? -12.597 -19.618 -14.928 1.00 32.13  ?  87  GLN A CB  1 
ATOM   551  C  CG  . GLN A 1 87  ? -13.094 -21.039 -15.051 1.00 30.52  ?  87  GLN A CG  1 
ATOM   552  C  CD  . GLN A 1 87  ? -13.986 -21.435 -13.867 1.00 31.31  ?  87  GLN A CD  1 
ATOM   553  O  OE1 . GLN A 1 87  ? -13.967 -20.793 -12.818 1.00 32.45  ?  87  GLN A OE1 1 
ATOM   554  N  NE2 . GLN A 1 87  ? -14.792 -22.471 -14.053 1.00 32.14  ?  87  GLN A NE2 1 
ATOM   555  N  N   . TYR A 1 88  ? -9.981  -20.994 -16.446 1.00 31.57  ?  88  TYR A N   1 
ATOM   556  C  CA  . TYR A 1 88  ? -8.676  -21.646 -16.412 1.00 31.86  ?  88  TYR A CA  1 
ATOM   557  C  C   . TYR A 1 88  ? -8.572  -22.555 -17.623 1.00 35.45  ?  88  TYR A C   1 
ATOM   558  O  O   . TYR A 1 88  ? -9.571  -22.866 -18.282 1.00 31.98  ?  88  TYR A O   1 
ATOM   559  C  CB  . TYR A 1 88  ? -8.443  -22.447 -15.117 1.00 30.98  ?  88  TYR A CB  1 
ATOM   560  C  CG  . TYR A 1 88  ? -9.628  -23.266 -14.668 1.00 31.65  ?  88  TYR A CG  1 
ATOM   561  C  CD1 . TYR A 1 88  ? -9.917  -24.507 -15.253 1.00 29.34  ?  88  TYR A CD1 1 
ATOM   562  C  CD2 . TYR A 1 88  ? -10.464 -22.806 -13.647 1.00 29.46  ?  88  TYR A CD2 1 
ATOM   563  C  CE1 . TYR A 1 88  ? -11.013 -25.255 -14.831 1.00 32.23  ?  88  TYR A CE1 1 
ATOM   564  C  CE2 . TYR A 1 88  ? -11.560 -23.559 -13.221 1.00 32.24  ?  88  TYR A CE2 1 
ATOM   565  C  CZ  . TYR A 1 88  ? -11.829 -24.769 -13.815 1.00 33.84  ?  88  TYR A CZ  1 
ATOM   566  O  OH  . TYR A 1 88  ? -12.919 -25.489 -13.377 1.00 33.53  ?  88  TYR A OH  1 
ATOM   567  N  N   . ALA A 1 89  ? -7.345  -22.994 -17.894 1.00 32.04  ?  89  ALA A N   1 
ATOM   568  C  CA  . ALA A 1 89  ? -7.091  -23.810 -19.069 1.00 34.69  ?  89  ALA A CA  1 
ATOM   569  C  C   . ALA A 1 89  ? -7.864  -25.119 -19.005 1.00 37.70  ?  89  ALA A C   1 
ATOM   570  O  O   . ALA A 1 89  ? -8.039  -25.719 -17.938 1.00 31.14  ?  89  ALA A O   1 
ATOM   571  C  CB  . ALA A 1 89  ? -5.590  -24.089 -19.206 1.00 35.08  ?  89  ALA A CB  1 
ATOM   572  N  N   . LEU A 1 90  ? -8.346  -25.550 -20.166 1.00 36.29  ?  90  LEU A N   1 
ATOM   573  C  CA  . LEU A 1 90  ? -8.959  -26.862 -20.289 1.00 39.29  ?  90  LEU A CA  1 
ATOM   574  C  C   . LEU A 1 90  ? -7.905  -27.945 -20.074 1.00 40.35  ?  90  LEU A C   1 
ATOM   575  O  O   . LEU A 1 90  ? -6.841  -27.913 -20.691 1.00 41.19  ?  90  LEU A O   1 
ATOM   576  C  CB  . LEU A 1 90  ? -9.578  -26.996 -21.680 1.00 43.98  ?  90  LEU A CB  1 
ATOM   577  C  CG  . LEU A 1 90  ? -10.785 -27.876 -21.962 1.00 46.08  ?  90  LEU A CG  1 
ATOM   578  C  CD1 . LEU A 1 90  ? -11.941 -27.591 -21.014 1.00 45.66  ?  90  LEU A CD1 1 
ATOM   579  C  CD2 . LEU A 1 90  ? -11.190 -27.671 -23.413 1.00 45.76  ?  90  LEU A CD2 1 
ATOM   580  N  N   . THR A 1 91  ? -8.200  -28.917 -19.216 1.00 36.58  ?  91  THR A N   1 
ATOM   581  C  CA  . THR A 1 91  ? -7.293  -30.034 -18.993 1.00 40.47  ?  91  THR A CA  1 
ATOM   582  C  C   . THR A 1 91  ? -7.827  -31.347 -19.536 1.00 37.92  ?  91  THR A C   1 
ATOM   583  O  O   . THR A 1 91  ? -7.213  -32.388 -19.309 1.00 39.40  ?  91  THR A O   1 
ATOM   584  C  CB  . THR A 1 91  ? -7.020  -30.197 -17.504 1.00 38.88  ?  91  THR A CB  1 
ATOM   585  O  OG1 . THR A 1 91  ? -8.268  -30.460 -16.835 1.00 41.07  ?  91  THR A OG1 1 
ATOM   586  C  CG2 . THR A 1 91  ? -6.373  -28.934 -16.961 1.00 36.42  ?  91  THR A CG2 1 
ATOM   587  N  N   . ILE A 1 92  ? -8.977  -31.333 -20.200 1.00 38.97  ?  92  ILE A N   1 
ATOM   588  C  CA  . ILE A 1 92  ? -9.607  -32.552 -20.706 1.00 39.40  ?  92  ILE A CA  1 
ATOM   589  C  C   . ILE A 1 92  ? -10.103 -32.273 -22.106 1.00 41.44  ?  92  ILE A C   1 
ATOM   590  O  O   . ILE A 1 92  ? -10.215 -31.100 -22.510 1.00 40.49  ?  92  ILE A O   1 
ATOM   591  C  CB  . ILE A 1 92  ? -10.781 -33.010 -19.807 1.00 43.14  ?  92  ILE A CB  1 
ATOM   592  C  CG1 . ILE A 1 92  ? -11.813 -31.875 -19.645 1.00 40.16  ?  92  ILE A CG1 1 
ATOM   593  C  CG2 . ILE A 1 92  ? -10.277 -33.478 -18.421 1.00 39.99  ?  92  ILE A CG2 1 
ATOM   594  C  CD1 . ILE A 1 92  ? -12.940 -32.198 -18.671 1.00 40.68  ?  92  ILE A CD1 1 
ATOM   595  N  N   . PRO A 1 93  ? -10.379 -33.316 -22.897 1.00 42.74  ?  93  PRO A N   1 
ATOM   596  C  CA  . PRO A 1 93  ? -10.963 -33.094 -24.231 1.00 46.16  ?  93  PRO A CA  1 
ATOM   597  C  C   . PRO A 1 93  ? -12.235 -32.269 -24.117 1.00 44.58  ?  93  PRO A C   1 
ATOM   598  O  O   . PRO A 1 93  ? -13.012 -32.444 -23.165 1.00 42.58  ?  93  PRO A O   1 
ATOM   599  C  CB  . PRO A 1 93  ? -11.252 -34.515 -24.740 1.00 46.33  ?  93  PRO A CB  1 
ATOM   600  C  CG  . PRO A 1 93  ? -10.251 -35.374 -24.042 1.00 47.40  ?  93  PRO A CG  1 
ATOM   601  C  CD  . PRO A 1 93  ? -10.025 -34.742 -22.678 1.00 46.32  ?  93  PRO A CD  1 
ATOM   602  N  N   . PRO A 1 94  ? -12.476 -31.346 -25.054 1.00 45.42  ?  94  PRO A N   1 
ATOM   603  C  CA  . PRO A 1 94  ? -13.639 -30.451 -24.915 1.00 46.12  ?  94  PRO A CA  1 
ATOM   604  C  C   . PRO A 1 94  ? -14.970 -31.183 -24.881 1.00 45.81  ?  94  PRO A C   1 
ATOM   605  O  O   . PRO A 1 94  ? -15.894 -30.741 -24.186 1.00 44.48  ?  94  PRO A O   1 
ATOM   606  C  CB  . PRO A 1 94  ? -13.526 -29.517 -26.135 1.00 45.78  ?  94  PRO A CB  1 
ATOM   607  C  CG  . PRO A 1 94  ? -12.590 -30.173 -27.077 1.00 47.07  ?  94  PRO A CG  1 
ATOM   608  C  CD  . PRO A 1 94  ? -11.703 -31.093 -26.283 1.00 48.95  ?  94  PRO A CD  1 
ATOM   609  N  N   . GLU A 1 95  ? -15.089 -32.312 -25.582 1.00 47.37  ?  95  GLU A N   1 
ATOM   610  C  CA  . GLU A 1 95  ? -16.328 -33.086 -25.544 1.00 48.41  ?  95  GLU A CA  1 
ATOM   611  C  C   . GLU A 1 95  ? -16.643 -33.608 -24.145 1.00 49.29  ?  95  GLU A C   1 
ATOM   612  O  O   . GLU A 1 95  ? -17.806 -33.924 -23.860 1.00 49.48  ?  95  GLU A O   1 
ATOM   613  C  CB  . GLU A 1 95  ? -16.248 -34.255 -26.539 1.00 49.68  ?  95  GLU A CB  1 
ATOM   614  C  CG  . GLU A 1 95  ? -15.027 -35.156 -26.368 1.00 54.24  ?  95  GLU A CG  1 
ATOM   615  C  CD  . GLU A 1 95  ? -13.820 -34.702 -27.188 1.00 55.58  ?  95  GLU A CD  1 
ATOM   616  O  OE1 . GLU A 1 95  ? -13.691 -33.482 -27.441 1.00 48.77  ?  95  GLU A OE1 1 
ATOM   617  O  OE2 . GLU A 1 95  ? -12.996 -35.573 -27.573 1.00 58.00  ?  95  GLU A OE2 1 
ATOM   618  N  N   . VAL A 1 96  ? -15.644 -33.688 -23.259 1.00 45.56  ?  96  VAL A N   1 
ATOM   619  C  CA  . VAL A 1 96  ? -15.877 -34.261 -21.937 1.00 46.43  ?  96  VAL A CA  1 
ATOM   620  C  C   . VAL A 1 96  ? -16.579 -33.275 -21.003 1.00 43.25  ?  96  VAL A C   1 
ATOM   621  O  O   . VAL A 1 96  ? -17.265 -33.689 -20.062 1.00 42.26  ?  96  VAL A O   1 
ATOM   622  C  CB  . VAL A 1 96  ? -14.554 -34.767 -21.345 1.00 44.39  ?  96  VAL A CB  1 
ATOM   623  C  CG1 . VAL A 1 96  ? -14.765 -35.346 -19.951 1.00 42.69  ?  96  VAL A CG1 1 
ATOM   624  C  CG2 . VAL A 1 96  ? -13.959 -35.815 -22.265 1.00 43.94  ?  96  VAL A CG2 1 
ATOM   625  N  N   . VAL A 1 97  ? -16.426 -31.970 -21.234 1.00 39.93  ?  97  VAL A N   1 
ATOM   626  C  CA  . VAL A 1 97  ? -17.211 -30.998 -20.479 1.00 42.47  ?  97  VAL A CA  1 
ATOM   627  C  C   . VAL A 1 97  ? -18.697 -31.231 -20.716 1.00 45.86  ?  97  VAL A C   1 
ATOM   628  O  O   . VAL A 1 97  ? -19.522 -30.983 -19.829 1.00 43.01  ?  97  VAL A O   1 
ATOM   629  C  CB  . VAL A 1 97  ? -16.790 -29.563 -20.861 1.00 41.98  ?  97  VAL A CB  1 
ATOM   630  C  CG1 . VAL A 1 97  ? -17.734 -28.541 -20.252 1.00 39.25  ?  97  VAL A CG1 1 
ATOM   631  C  CG2 . VAL A 1 97  ? -15.338 -29.305 -20.435 1.00 43.66  ?  97  VAL A CG2 1 
ATOM   632  N  N   . ASN A 1 98  ? -19.056 -31.727 -21.903 1.00 48.37  ?  98  ASN A N   1 
ATOM   633  C  CA  . ASN A 1 98  ? -20.427 -32.115 -22.251 1.00 47.42  ?  98  ASN A CA  1 
ATOM   634  C  C   . ASN A 1 98  ? -20.681 -33.603 -22.035 1.00 55.18  ?  98  ASN A C   1 
ATOM   635  O  O   . ASN A 1 98  ? -21.398 -34.241 -22.817 1.00 54.89  ?  98  ASN A O   1 
ATOM   636  C  CB  . ASN A 1 98  ? -20.725 -31.721 -23.694 1.00 51.42  ?  98  ASN A CB  1 
ATOM   637  C  CG  . ASN A 1 98  ? -22.215 -31.590 -23.963 1.00 57.21  ?  98  ASN A CG  1 
ATOM   638  O  OD1 . ASN A 1 98  ? -22.968 -31.081 -23.130 1.00 57.45  ?  98  ASN A OD1 1 
ATOM   639  N  ND2 . ASN A 1 98  ? -22.649 -32.073 -25.121 1.00 58.09  ?  98  ASN A ND2 1 
ATOM   640  N  N   . ASN A 1 99  ? -20.105 -34.165 -20.968 1.00 48.91  ?  99  ASN A N   1 
ATOM   641  C  CA  . ASN A 1 99  ? -20.215 -35.594 -20.685 1.00 57.38  ?  99  ASN A CA  1 
ATOM   642  C  C   . ASN A 1 99  ? -21.656 -36.095 -20.700 1.00 60.05  ?  99  ASN A C   1 
ATOM   643  O  O   . ASN A 1 99  ? -21.973 -37.084 -21.370 1.00 58.65  ?  99  ASN A O   1 
ATOM   644  C  CB  . ASN A 1 99  ? -19.595 -35.887 -19.329 1.00 54.88  ?  99  ASN A CB  1 
ATOM   645  C  CG  . ASN A 1 99  ? -19.412 -37.341 -19.097 1.00 60.13  ?  99  ASN A CG  1 
ATOM   646  O  OD1 . ASN A 1 99  ? -19.190 -38.117 -20.037 1.00 61.74  ?  99  ASN A OD1 1 
ATOM   647  N  ND2 . ASN A 1 99  ? -19.557 -37.746 -17.846 1.00 60.96  ?  99  ASN A ND2 1 
ATOM   648  N  N   . MET A 1 100 ? -22.528 -35.466 -19.908 1.00 59.41  ?  100 MET A N   1 
ATOM   649  C  CA  . MET A 1 100 ? -23.914 -35.917 -19.834 1.00 59.62  ?  100 MET A CA  1 
ATOM   650  C  C   . MET A 1 100 ? -24.601 -35.816 -21.189 1.00 60.30  ?  100 MET A C   1 
ATOM   651  O  O   . MET A 1 100 ? -25.388 -36.695 -21.555 1.00 61.66  ?  100 MET A O   1 
ATOM   652  C  CB  . MET A 1 100 ? -24.668 -35.117 -18.769 1.00 60.26  ?  100 MET A CB  1 
ATOM   653  C  CG  . MET A 1 100 ? -24.195 -35.341 -17.335 1.00 61.53  ?  100 MET A CG  1 
ATOM   654  S  SD  . MET A 1 100 ? -24.312 -37.040 -16.716 1.00 70.48  ?  100 MET A SD  1 
ATOM   655  C  CE  . MET A 1 100 ? -26.085 -37.248 -16.668 1.00 61.58  ?  100 MET A CE  1 
ATOM   656  N  N   . GLY A 1 101 ? -24.311 -34.756 -21.947 1.00 56.37  ?  101 GLY A N   1 
ATOM   657  C  CA  . GLY A 1 101 ? -24.881 -34.620 -23.276 1.00 59.92  ?  101 GLY A CA  1 
ATOM   658  C  C   . GLY A 1 101 ? -24.500 -35.748 -24.220 1.00 65.19  ?  101 GLY A C   1 
ATOM   659  O  O   . GLY A 1 101 ? -25.301 -36.146 -25.069 1.00 68.99  ?  101 GLY A O   1 
ATOM   660  N  N   . ASN A 1 102 ? -23.281 -36.283 -24.086 1.00 62.47  ?  102 ASN A N   1 
ATOM   661  C  CA  . ASN A 1 102 ? -22.859 -37.411 -24.916 1.00 65.40  ?  102 ASN A CA  1 
ATOM   662  C  C   . ASN A 1 102 ? -23.413 -38.734 -24.393 1.00 65.70  ?  102 ASN A C   1 
ATOM   663  O  O   . ASN A 1 102 ? -23.860 -39.578 -25.181 1.00 64.80  ?  102 ASN A O   1 
ATOM   664  C  CB  . ASN A 1 102 ? -21.331 -37.473 -24.992 1.00 61.12  ?  102 ASN A CB  1 
ATOM   665  C  CG  . ASN A 1 102 ? -20.731 -36.251 -25.658 1.00 66.45  ?  102 ASN A CG  1 
ATOM   666  O  OD1 . ASN A 1 102 ? -21.359 -35.623 -26.511 1.00 69.83  ?  102 ASN A OD1 1 
ATOM   667  N  ND2 . ASN A 1 102 ? -19.504 -35.907 -25.271 1.00 63.65  ?  102 ASN A ND2 1 
ATOM   668  N  N   . ILE A 1 103 ? -23.377 -38.927 -23.068 1.00 59.89  ?  103 ILE A N   1 
ATOM   669  C  CA  . ILE A 1 103 ? -23.979 -40.099 -22.435 1.00 63.02  ?  103 ILE A CA  1 
ATOM   670  C  C   . ILE A 1 103 ? -25.412 -40.285 -22.921 1.00 66.98  ?  103 ILE A C   1 
ATOM   671  O  O   . ILE A 1 103 ? -25.859 -41.407 -23.197 1.00 66.35  ?  103 ILE A O   1 
ATOM   672  C  CB  . ILE A 1 103 ? -23.919 -39.949 -20.900 1.00 63.57  ?  103 ILE A CB  1 
ATOM   673  C  CG1 . ILE A 1 103 ? -22.549 -40.371 -20.360 1.00 61.74  ?  103 ILE A CG1 1 
ATOM   674  C  CG2 . ILE A 1 103 ? -25.035 -40.727 -20.218 1.00 60.42  ?  103 ILE A CG2 1 
ATOM   675  C  CD1 . ILE A 1 103 ? -22.161 -39.660 -19.062 1.00 60.14  ?  103 ILE A CD1 1 
ATOM   676  N  N   . ASN A 1 104 ? -26.147 -39.178 -23.052 1.00 65.72  ?  104 ASN A N   1 
ATOM   677  C  CA  . ASN A 1 104 ? -27.544 -39.246 -23.469 1.00 68.11  ?  104 ASN A CA  1 
ATOM   678  C  C   . ASN A 1 104 ? -27.672 -39.625 -24.942 1.00 67.31  ?  104 ASN A C   1 
ATOM   679  O  O   . ASN A 1 104 ? -28.516 -40.455 -25.300 1.00 70.20  ?  104 ASN A O   1 
ATOM   680  C  CB  . ASN A 1 104 ? -28.227 -37.906 -23.190 1.00 65.12  ?  104 ASN A CB  1 
ATOM   681  C  CG  . ASN A 1 104 ? -28.348 -37.614 -21.705 1.00 63.96  ?  104 ASN A CG  1 
ATOM   682  O  OD1 . ASN A 1 104 ? -28.277 -38.521 -20.880 1.00 66.16  ?  104 ASN A OD1 1 
ATOM   683  N  ND2 . ASN A 1 104 ? -28.533 -36.346 -21.359 1.00 64.70  ?  104 ASN A ND2 1 
ATOM   684  N  N   . SER A 1 105 ? -26.829 -39.045 -25.807 1.00 65.05  ?  105 SER A N   1 
ATOM   685  C  CA  . SER A 1 105 ? -26.998 -39.228 -27.247 1.00 69.41  ?  105 SER A CA  1 
ATOM   686  C  C   . SER A 1 105 ? -26.615 -40.633 -27.703 1.00 70.07  ?  105 SER A C   1 
ATOM   687  O  O   . SER A 1 105 ? -27.170 -41.132 -28.689 1.00 73.22  ?  105 SER A O   1 
ATOM   688  C  CB  . SER A 1 105 ? -26.170 -38.198 -28.013 1.00 67.95  ?  105 SER A CB  1 
ATOM   689  O  OG  . SER A 1 105 ? -24.818 -38.618 -28.102 1.00 70.11  ?  105 SER A OG  1 
ATOM   690  N  N   . ALA A 1 106 ? -25.675 -41.282 -27.021 1.00 68.04  ?  106 ALA A N   1 
ATOM   691  C  CA  . ALA A 1 106 ? -25.195 -42.592 -27.440 1.00 70.28  ?  106 ALA A CA  1 
ATOM   692  C  C   . ALA A 1 106 ? -25.962 -43.750 -26.801 1.00 68.64  ?  106 ALA A C   1 
ATOM   693  O  O   . ALA A 1 106 ? -25.532 -44.901 -26.928 1.00 69.53  ?  106 ALA A O   1 
ATOM   694  C  CB  . ALA A 1 106 ? -23.700 -42.722 -27.134 1.00 67.26  ?  106 ALA A CB  1 
ATOM   695  N  N   . GLY A 1 107 ? -27.080 -43.476 -26.127 1.00 66.35  ?  107 GLY A N   1 
ATOM   696  C  CA  . GLY A 1 107 ? -27.825 -44.523 -25.452 1.00 64.72  ?  107 GLY A CA  1 
ATOM   697  C  C   . GLY A 1 107 ? -27.169 -45.058 -24.198 1.00 68.15  ?  107 GLY A C   1 
ATOM   698  O  O   . GLY A 1 107 ? -27.478 -46.177 -23.773 1.00 67.44  ?  107 GLY A O   1 
ATOM   699  N  N   . LEU A 1 108 ? -26.261 -44.287 -23.594 1.00 65.86  ?  108 LEU A N   1 
ATOM   700  C  CA  . LEU A 1 108 ? -25.535 -44.685 -22.396 1.00 60.84  ?  108 LEU A CA  1 
ATOM   701  C  C   . LEU A 1 108 ? -26.261 -44.323 -21.110 1.00 61.66  ?  108 LEU A C   1 
ATOM   702  O  O   . LEU A 1 108 ? -25.830 -44.764 -20.036 1.00 55.77  ?  108 LEU A O   1 
ATOM   703  C  CB  . LEU A 1 108 ? -24.152 -44.020 -22.366 1.00 62.32  ?  108 LEU A CB  1 
ATOM   704  C  CG  . LEU A 1 108 ? -23.117 -44.375 -23.429 1.00 61.61  ?  108 LEU A CG  1 
ATOM   705  C  CD1 . LEU A 1 108 ? -21.892 -43.498 -23.292 1.00 57.11  ?  108 LEU A CD1 1 
ATOM   706  C  CD2 . LEU A 1 108 ? -22.743 -45.818 -23.293 1.00 62.48  ?  108 LEU A CD2 1 
ATOM   707  N  N   . ARG A 1 109 ? -27.336 -43.526 -21.195 1.00 59.88  ?  109 ARG A N   1 
ATOM   708  C  CA  . ARG A 1 109 ? -27.930 -42.946 -19.995 1.00 58.22  ?  109 ARG A CA  1 
ATOM   709  C  C   . ARG A 1 109 ? -28.390 -44.019 -19.022 1.00 59.32  ?  109 ARG A C   1 
ATOM   710  O  O   . ARG A 1 109 ? -28.164 -43.902 -17.811 1.00 56.48  ?  109 ARG A O   1 
ATOM   711  C  CB  . ARG A 1 109 ? -29.102 -42.032 -20.360 1.00 63.70  ?  109 ARG A CB  1 
ATOM   712  C  CG  . ARG A 1 109 ? -29.573 -41.174 -19.189 1.00 66.12  ?  109 ARG A CG  1 
ATOM   713  C  CD  . ARG A 1 109 ? -30.566 -40.094 -19.604 1.00 69.22  ?  109 ARG A CD  1 
ATOM   714  N  NE  . ARG A 1 109 ? -30.943 -39.235 -18.483 1.00 74.38  ?  109 ARG A NE  1 
ATOM   715  C  CZ  . ARG A 1 109 ? -30.209 -38.227 -18.023 1.00 72.90  ?  109 ARG A CZ  1 
ATOM   716  N  NH1 . ARG A 1 109 ? -29.034 -37.925 -18.552 1.00 69.14  ?  109 ARG A NH1 1 
ATOM   717  N  NH2 . ARG A 1 109 ? -30.662 -37.507 -17.000 1.00 73.91  ?  109 ARG A NH2 1 
ATOM   718  N  N   . ASN A 1 110 ? -29.033 -45.076 -19.526 1.00 59.98  ?  110 ASN A N   1 
ATOM   719  C  CA  . ASN A 1 110 ? -29.574 -46.090 -18.629 1.00 58.74  ?  110 ASN A CA  1 
ATOM   720  C  C   . ASN A 1 110 ? -28.461 -46.767 -17.847 1.00 54.13  ?  110 ASN A C   1 
ATOM   721  O  O   . ASN A 1 110 ? -28.560 -46.942 -16.629 1.00 55.01  ?  110 ASN A O   1 
ATOM   722  C  CB  . ASN A 1 110 ? -30.387 -47.122 -19.412 1.00 60.75  ?  110 ASN A CB  1 
ATOM   723  C  CG  . ASN A 1 110 ? -31.689 -46.559 -19.923 1.00 67.94  ?  110 ASN A CG  1 
ATOM   724  O  OD1 . ASN A 1 110 ? -32.209 -45.581 -19.387 1.00 75.21  ?  110 ASN A OD1 1 
ATOM   725  N  ND2 . ASN A 1 110 ? -32.237 -47.183 -20.966 1.00 72.24  ?  110 ASN A ND2 1 
ATOM   726  N  N   . ALA A 1 111 ? -27.388 -47.157 -18.535 1.00 51.66  ?  111 ALA A N   1 
ATOM   727  C  CA  . ALA A 1 111 ? -26.256 -47.754 -17.835 1.00 55.61  ?  111 ALA A CA  1 
ATOM   728  C  C   . ALA A 1 111 ? -25.647 -46.765 -16.844 1.00 51.13  ?  111 ALA A C   1 
ATOM   729  O  O   . ALA A 1 111 ? -25.295 -47.139 -15.721 1.00 52.71  ?  111 ALA A O   1 
ATOM   730  C  CB  . ALA A 1 111 ? -25.216 -48.236 -18.841 1.00 50.37  ?  111 ALA A CB  1 
ATOM   731  N  N   . VAL A 1 112 ? -25.542 -45.496 -17.234 1.00 49.25  ?  112 VAL A N   1 
ATOM   732  C  CA  . VAL A 1 112 ? -25.000 -44.483 -16.332 1.00 52.40  ?  112 VAL A CA  1 
ATOM   733  C  C   . VAL A 1 112 ? -25.946 -44.240 -15.161 1.00 52.55  ?  112 VAL A C   1 
ATOM   734  O  O   . VAL A 1 112 ? -25.543 -44.327 -13.995 1.00 48.54  ?  112 VAL A O   1 
ATOM   735  C  CB  . VAL A 1 112 ? -24.698 -43.186 -17.102 1.00 50.25  ?  112 VAL A CB  1 
ATOM   736  C  CG1 . VAL A 1 112 ? -24.288 -42.076 -16.130 1.00 51.77  ?  112 VAL A CG1 1 
ATOM   737  C  CG2 . VAL A 1 112 ? -23.586 -43.436 -18.115 1.00 51.85  ?  112 VAL A CG2 1 
ATOM   738  N  N   . MET A 1 113 ? -27.222 -43.945 -15.451 1.00 53.26  ?  113 MET A N   1 
ATOM   739  C  CA  . MET A 1 113 ? -28.171 -43.637 -14.382 1.00 52.45  ?  113 MET A CA  1 
ATOM   740  C  C   . MET A 1 113 ? -28.329 -44.810 -13.421 1.00 51.18  ?  113 MET A C   1 
ATOM   741  O  O   . MET A 1 113 ? -28.460 -44.612 -12.207 1.00 48.59  ?  113 MET A O   1 
ATOM   742  C  CB  . MET A 1 113 ? -29.524 -43.239 -14.972 1.00 56.12  ?  113 MET A CB  1 
ATOM   743  C  CG  . MET A 1 113 ? -29.537 -41.926 -15.772 1.00 63.51  ?  113 MET A CG  1 
ATOM   744  S  SD  . MET A 1 113 ? -29.056 -40.408 -14.890 1.00 68.24  ?  113 MET A SD  1 
ATOM   745  C  CE  . MET A 1 113 ? -30.402 -40.215 -13.706 1.00 56.03  ?  113 MET A CE  1 
ATOM   746  N  N   . LYS A 1 114 ? -28.320 -46.041 -13.944 1.00 52.58  ?  114 LYS A N   1 
ATOM   747  C  CA  . LYS A 1 114 ? -28.367 -47.216 -13.080 1.00 53.44  ?  114 LYS A CA  1 
ATOM   748  C  C   . LYS A 1 114 ? -27.144 -47.286 -12.171 1.00 52.20  ?  114 LYS A C   1 
ATOM   749  O  O   . LYS A 1 114 ? -27.255 -47.636 -10.988 1.00 51.03  ?  114 LYS A O   1 
ATOM   750  C  CB  . LYS A 1 114 ? -28.471 -48.480 -13.937 1.00 56.82  ?  114 LYS A CB  1 
ATOM   751  C  CG  . LYS A 1 114 ? -28.566 -49.778 -13.155 1.00 62.30  ?  114 LYS A CG  1 
ATOM   752  C  CD  . LYS A 1 114 ? -29.480 -50.776 -13.861 1.00 66.14  ?  114 LYS A CD  1 
ATOM   753  C  CE  . LYS A 1 114 ? -29.038 -50.999 -15.311 1.00 69.86  ?  114 LYS A CE  1 
ATOM   754  N  NZ  . LYS A 1 114 ? -28.130 -52.172 -15.477 1.00 67.40  ?  114 LYS A NZ  1 
ATOM   755  N  N   . THR A 1 115 ? -25.963 -46.969 -12.710 1.00 49.88  ?  115 THR A N   1 
ATOM   756  C  CA  . THR A 1 115 ? -24.755 -46.997 -11.892 1.00 49.56  ?  115 THR A CA  1 
ATOM   757  C  C   . THR A 1 115 ? -24.797 -45.935 -10.797 1.00 48.60  ?  115 THR A C   1 
ATOM   758  O  O   . THR A 1 115 ? -24.338 -46.171 -9.674  1.00 46.15  ?  115 THR A O   1 
ATOM   759  C  CB  . THR A 1 115 ? -23.520 -46.802 -12.772 1.00 51.44  ?  115 THR A CB  1 
ATOM   760  O  OG1 . THR A 1 115 ? -23.467 -47.835 -13.763 1.00 52.53  ?  115 THR A OG1 1 
ATOM   761  C  CG2 . THR A 1 115 ? -22.263 -46.848 -11.936 1.00 46.74  ?  115 THR A CG2 1 
ATOM   762  N  N   . LEU A 1 116 ? -25.338 -44.761 -11.105 1.00 47.17  ?  116 LEU A N   1 
ATOM   763  C  CA  . LEU A 1 116 ? -25.355 -43.659 -10.152 1.00 47.02  ?  116 LEU A CA  1 
ATOM   764  C  C   . LEU A 1 116 ? -26.444 -43.787 -9.093  1.00 52.19  ?  116 LEU A C   1 
ATOM   765  O  O   . LEU A 1 116 ? -26.449 -42.998 -8.143  1.00 54.99  ?  116 LEU A O   1 
ATOM   766  C  CB  . LEU A 1 116 ? -25.530 -42.340 -10.897 1.00 43.83  ?  116 LEU A CB  1 
ATOM   767  C  CG  . LEU A 1 116 ? -24.370 -41.996 -11.819 1.00 44.17  ?  116 LEU A CG  1 
ATOM   768  C  CD1 . LEU A 1 116 ? -24.603 -40.636 -12.428 1.00 43.75  ?  116 LEU A CD1 1 
ATOM   769  C  CD2 . LEU A 1 116 ? -23.046 -42.036 -11.047 1.00 43.59  ?  116 LEU A CD2 1 
ATOM   770  N  N   . SER A 1 117 ? -27.357 -44.751 -9.224  1.00 53.51  ?  117 SER A N   1 
ATOM   771  C  CA  . SER A 1 117 ? -28.481 -44.873 -8.300  1.00 56.88  ?  117 SER A CA  1 
ATOM   772  C  C   . SER A 1 117 ? -28.098 -45.730 -7.099  1.00 58.63  ?  117 SER A C   1 
ATOM   773  O  O   . SER A 1 117 ? -27.827 -46.927 -7.272  1.00 60.32  ?  117 SER A O   1 
ATOM   774  C  CB  . SER A 1 117 ? -29.680 -45.485 -8.998  1.00 56.10  ?  117 SER A CB  1 
ATOM   775  O  OG  . SER A 1 117 ? -29.383 -46.808 -9.404  1.00 60.99  ?  117 SER A OG  1 
ATOM   776  N  N   . PRO A 1 118 ? -28.077 -45.182 -5.876  1.00 57.22  ?  118 PRO A N   1 
ATOM   777  C  CA  . PRO A 1 118 ? -27.840 -46.033 -4.696  1.00 60.62  ?  118 PRO A CA  1 
ATOM   778  C  C   . PRO A 1 118 ? -28.902 -47.104 -4.503  1.00 64.20  ?  118 PRO A C   1 
ATOM   779  O  O   . PRO A 1 118 ? -28.637 -48.110 -3.832  1.00 62.53  ?  118 PRO A O   1 
ATOM   780  C  CB  . PRO A 1 118 ? -27.841 -45.034 -3.526  1.00 58.13  ?  118 PRO A CB  1 
ATOM   781  C  CG  . PRO A 1 118 ? -27.602 -43.694 -4.149  1.00 52.67  ?  118 PRO A CG  1 
ATOM   782  C  CD  . PRO A 1 118 ? -28.227 -43.762 -5.511  1.00 54.02  ?  118 PRO A CD  1 
ATOM   783  N  N   . GLN A 1 119 ? -30.094 -46.918 -5.074  1.00 65.07  ?  119 GLN A N   1 
ATOM   784  C  CA  . GLN A 1 119 ? -31.175 -47.888 -4.959  1.00 66.41  ?  119 GLN A CA  1 
ATOM   785  C  C   . GLN A 1 119 ? -31.001 -49.079 -5.895  1.00 66.81  ?  119 GLN A C   1 
ATOM   786  O  O   . GLN A 1 119 ? -31.651 -50.110 -5.691  1.00 68.42  ?  119 GLN A O   1 
ATOM   787  C  CB  . GLN A 1 119 ? -32.514 -47.204 -5.240  1.00 65.41  ?  119 GLN A CB  1 
ATOM   788  C  CG  . GLN A 1 119 ? -32.820 -46.007 -4.339  1.00 71.70  ?  119 GLN A CG  1 
ATOM   789  C  CD  . GLN A 1 119 ? -32.015 -44.756 -4.705  1.00 74.61  ?  119 GLN A CD  1 
ATOM   790  O  OE1 . GLN A 1 119 ? -31.335 -44.711 -5.735  1.00 74.50  ?  119 GLN A OE1 1 
ATOM   791  N  NE2 . GLN A 1 119 ? -32.096 -43.733 -3.860  1.00 76.04  ?  119 GLN A NE2 1 
ATOM   792  N  N   . ALA A 1 120 ? -30.149 -48.961 -6.913  1.00 65.37  ?  120 ALA A N   1 
ATOM   793  C  CA  . ALA A 1 120 ? -29.867 -50.064 -7.823  1.00 61.28  ?  120 ALA A CA  1 
ATOM   794  C  C   . ALA A 1 120 ? -28.771 -50.999 -7.318  1.00 64.66  ?  120 ALA A C   1 
ATOM   795  O  O   . ALA A 1 120 ? -28.527 -52.032 -7.949  1.00 64.63  ?  120 ALA A O   1 
ATOM   796  C  CB  . ALA A 1 120 ? -29.479 -49.522 -9.204  1.00 60.58  ?  120 ALA A CB  1 
ATOM   797  N  N   . ASP A 1 121 ? -28.109 -50.667 -6.206  1.00 60.20  ?  121 ASP A N   1 
ATOM   798  C  CA  . ASP A 1 121 ? -27.049 -51.488 -5.610  1.00 57.84  ?  121 ASP A CA  1 
ATOM   799  C  C   . ASP A 1 121 ? -27.443 -51.699 -4.151  1.00 56.25  ?  121 ASP A C   1 
ATOM   800  O  O   . ASP A 1 121 ? -27.006 -50.963 -3.263  1.00 47.62  ?  121 ASP A O   1 
ATOM   801  C  CB  . ASP A 1 121 ? -25.675 -50.805 -5.762  1.00 55.69  ?  121 ASP A CB  1 
ATOM   802  C  CG  . ASP A 1 121 ? -24.531 -51.583 -5.106  1.00 53.27  ?  121 ASP A CG  1 
ATOM   803  O  OD1 . ASP A 1 121 ? -24.779 -52.621 -4.465  1.00 51.08  ?  121 ASP A OD1 1 
ATOM   804  O  OD2 . ASP A 1 121 ? -23.361 -51.140 -5.235  1.00 54.24  ?  121 ASP A OD2 1 
ATOM   805  N  N   . ARG A 1 122 ? -28.268 -52.715 -3.897  1.00 55.19  ?  122 ARG A N   1 
ATOM   806  C  CA  . ARG A 1 122 ? -28.870 -52.859 -2.577  1.00 55.58  ?  122 ARG A CA  1 
ATOM   807  C  C   . ARG A 1 122 ? -27.861 -53.203 -1.489  1.00 47.59  ?  122 ARG A C   1 
ATOM   808  O  O   . ARG A 1 122 ? -28.197 -53.100 -0.306  1.00 49.89  ?  122 ARG A O   1 
ATOM   809  C  CB  . ARG A 1 122 ? -29.980 -53.911 -2.625  1.00 68.21  ?  122 ARG A CB  1 
ATOM   810  N  N   . GLU A 1 123 ? -26.646 -53.607 -1.844  1.00 47.32  ?  123 GLU A N   1 
ATOM   811  C  CA  . GLU A 1 123 ? -25.606 -53.798 -0.845  1.00 50.06  ?  123 GLU A CA  1 
ATOM   812  C  C   . GLU A 1 123 ? -24.805 -52.534 -0.555  1.00 44.22  ?  123 GLU A C   1 
ATOM   813  O  O   . GLU A 1 123 ? -24.017 -52.531 0.396   1.00 41.23  ?  123 GLU A O   1 
ATOM   814  C  CB  . GLU A 1 123 ? -24.640 -54.898 -1.282  1.00 51.84  ?  123 GLU A CB  1 
ATOM   815  C  CG  . GLU A 1 123 ? -25.042 -56.254 -0.769  1.00 57.91  ?  123 GLU A CG  1 
ATOM   816  C  CD  . GLU A 1 123 ? -26.202 -56.796 -1.550  1.00 63.17  ?  123 GLU A CD  1 
ATOM   817  O  OE1 . GLU A 1 123 ? -26.117 -56.795 -2.799  1.00 65.35  ?  123 GLU A OE1 1 
ATOM   818  O  OE2 . GLU A 1 123 ? -27.207 -57.199 -0.920  1.00 71.41  ?  123 GLU A OE2 1 
ATOM   819  N  N   . LEU A 1 124 ? -24.989 -51.476 -1.343  1.00 43.36  ?  124 LEU A N   1 
ATOM   820  C  CA  . LEU A 1 124 ? -24.115 -50.305 -1.248  1.00 44.69  ?  124 LEU A CA  1 
ATOM   821  C  C   . LEU A 1 124 ? -24.025 -49.771 0.179   1.00 41.85  ?  124 LEU A C   1 
ATOM   822  O  O   . LEU A 1 124 ? -22.924 -49.613 0.726   1.00 40.38  ?  124 LEU A O   1 
ATOM   823  C  CB  . LEU A 1 124 ? -24.604 -49.215 -2.197  1.00 44.57  ?  124 LEU A CB  1 
ATOM   824  C  CG  . LEU A 1 124 ? -23.656 -48.016 -2.267  1.00 42.98  ?  124 LEU A CG  1 
ATOM   825  C  CD1 . LEU A 1 124 ? -22.281 -48.496 -2.667  1.00 40.91  ?  124 LEU A CD1 1 
ATOM   826  C  CD2 . LEU A 1 124 ? -24.201 -47.012 -3.260  1.00 43.92  ?  124 LEU A CD2 1 
ATOM   827  N  N   . GLY A 1 125 ? -25.178 -49.512 0.805   1.00 38.38  ?  125 GLY A N   1 
ATOM   828  C  CA  . GLY A 1 125 ? -25.214 -48.992 2.158   1.00 38.70  ?  125 GLY A CA  1 
ATOM   829  C  C   . GLY A 1 125 ? -24.346 -49.750 3.143   1.00 41.50  ?  125 GLY A C   1 
ATOM   830  O  O   . GLY A 1 125 ? -23.442 -49.177 3.762   1.00 40.16  ?  125 GLY A O   1 
ATOM   831  N  N   . GLY A 1 126 ? -24.600 -51.048 3.298   1.00 35.88  ?  126 GLY A N   1 
ATOM   832  C  CA  . GLY A 1 126 ? -23.801 -51.831 4.227   1.00 38.19  ?  126 GLY A CA  1 
ATOM   833  C  C   . GLY A 1 126 ? -22.339 -51.911 3.830   1.00 34.94  ?  126 GLY A C   1 
ATOM   834  O  O   . GLY A 1 126 ? -21.449 -51.930 4.686   1.00 35.62  ?  126 GLY A O   1 
ATOM   835  N  N   . TRP A 1 127 ? -22.070 -51.973 2.530   1.00 34.96  ?  127 TRP A N   1 
ATOM   836  C  CA  . TRP A 1 127 ? -20.689 -52.063 2.063   1.00 36.21  ?  127 TRP A CA  1 
ATOM   837  C  C   . TRP A 1 127 ? -19.913 -50.779 2.373   1.00 34.43  ?  127 TRP A C   1 
ATOM   838  O  O   . TRP A 1 127 ? -18.773 -50.826 2.849   1.00 36.51  ?  127 TRP A O   1 
ATOM   839  C  CB  . TRP A 1 127 ? -20.682 -52.358 0.563   1.00 36.35  ?  127 TRP A CB  1 
ATOM   840  C  CG  . TRP A 1 127 ? -19.331 -52.464 -0.002  1.00 41.10  ?  127 TRP A CG  1 
ATOM   841  C  CD1 . TRP A 1 127 ? -18.536 -53.574 -0.039  1.00 41.47  ?  127 TRP A CD1 1 
ATOM   842  C  CD2 . TRP A 1 127 ? -18.581 -51.407 -0.607  1.00 40.12  ?  127 TRP A CD2 1 
ATOM   843  N  NE1 . TRP A 1 127 ? -17.339 -53.272 -0.640  1.00 39.73  ?  127 TRP A NE1 1 
ATOM   844  C  CE2 . TRP A 1 127 ? -17.340 -51.950 -1.000  1.00 42.21  ?  127 TRP A CE2 1 
ATOM   845  C  CE3 . TRP A 1 127 ? -18.840 -50.050 -0.852  1.00 40.54  ?  127 TRP A CE3 1 
ATOM   846  C  CZ2 . TRP A 1 127 ? -16.355 -51.187 -1.628  1.00 42.49  ?  127 TRP A CZ2 1 
ATOM   847  C  CZ3 . TRP A 1 127 ? -17.863 -49.295 -1.486  1.00 40.81  ?  127 TRP A CZ3 1 
ATOM   848  C  CH2 . TRP A 1 127 ? -16.637 -49.864 -1.861  1.00 39.33  ?  127 TRP A CH2 1 
ATOM   849  N  N   . LEU A 1 128 ? -20.519 -49.623 2.099   1.00 35.98  ?  128 LEU A N   1 
ATOM   850  C  CA  . LEU A 1 128 ? -19.898 -48.342 2.450   1.00 36.15  ?  128 LEU A CA  1 
ATOM   851  C  C   . LEU A 1 128 ? -19.653 -48.241 3.949   1.00 37.62  ?  128 LEU A C   1 
ATOM   852  O  O   . LEU A 1 128 ? -18.596 -47.767 4.390   1.00 32.42  ?  128 LEU A O   1 
ATOM   853  C  CB  . LEU A 1 128 ? -20.794 -47.199 1.980   1.00 34.85  ?  128 LEU A CB  1 
ATOM   854  C  CG  . LEU A 1 128 ? -20.672 -46.823 0.503   1.00 35.95  ?  128 LEU A CG  1 
ATOM   855  C  CD1 . LEU A 1 128 ? -21.745 -45.794 0.125   1.00 35.37  ?  128 LEU A CD1 1 
ATOM   856  C  CD2 . LEU A 1 128 ? -19.269 -46.296 0.184   1.00 36.81  ?  128 LEU A CD2 1 
ATOM   857  N  N   . GLU A 1 129 ? -20.620 -48.692 4.752   1.00 33.88  ?  129 GLU A N   1 
ATOM   858  C  CA  . GLU A 1 129 ? -20.445 -48.644 6.193   1.00 35.41  ?  129 GLU A CA  1 
ATOM   859  C  C   . GLU A 1 129 ? -19.274 -49.508 6.629   1.00 35.85  ?  129 GLU A C   1 
ATOM   860  O  O   . GLU A 1 129 ? -18.482 -49.100 7.484   1.00 32.87  ?  129 GLU A O   1 
ATOM   861  C  CB  . GLU A 1 129 ? -21.734 -49.075 6.898   1.00 36.42  ?  129 GLU A CB  1 
ATOM   862  C  CG  . GLU A 1 129 ? -21.591 -49.128 8.410   1.00 42.41  ?  129 GLU A CG  1 
ATOM   863  C  CD  . GLU A 1 129 ? -22.888 -49.505 9.119   1.00 51.13  ?  129 GLU A CD  1 
ATOM   864  O  OE1 . GLU A 1 129 ? -23.019 -49.188 10.317  1.00 52.62  ?  129 GLU A OE1 1 
ATOM   865  O  OE2 . GLU A 1 129 ? -23.785 -50.093 8.473   1.00 57.05  ?  129 GLU A OE2 1 
ATOM   866  N  N   . ALA A 1 130 ? -19.142 -50.713 6.055   1.00 36.17  ?  130 ALA A N   1 
ATOM   867  C  CA  . ALA A 1 130 ? -17.996 -51.546 6.400   1.00 37.92  ?  130 ALA A CA  1 
ATOM   868  C  C   . ALA A 1 130 ? -16.688 -50.904 5.945   1.00 32.27  ?  130 ALA A C   1 
ATOM   869  O  O   . ALA A 1 130 ? -15.675 -50.997 6.645   1.00 33.42  ?  130 ALA A O   1 
ATOM   870  C  CB  . ALA A 1 130 ? -18.148 -52.949 5.795   1.00 35.69  ?  130 ALA A CB  1 
ATOM   871  N  N   . GLN A 1 131 ? -16.676 -50.281 4.766   1.00 31.88  ?  131 GLN A N   1 
ATOM   872  C  CA  . GLN A 1 131 ? -15.454 -49.619 4.300   1.00 35.77  ?  131 GLN A CA  1 
ATOM   873  C  C   . GLN A 1 131 ? -15.035 -48.501 5.255   1.00 30.29  ?  131 GLN A C   1 
ATOM   874  O  O   . GLN A 1 131 ? -13.868 -48.401 5.643   1.00 31.59  ?  131 GLN A O   1 
ATOM   875  C  CB  . GLN A 1 131 ? -15.663 -49.059 2.890   1.00 37.05  ?  131 GLN A CB  1 
ATOM   876  C  CG  . GLN A 1 131 ? -15.840 -50.105 1.796   1.00 39.64  ?  131 GLN A CG  1 
ATOM   877  C  CD  . GLN A 1 131 ? -14.562 -50.884 1.531   1.00 40.94  ?  131 GLN A CD  1 
ATOM   878  O  OE1 . GLN A 1 131 ? -13.536 -50.313 1.152   1.00 43.29  ?  131 GLN A OE1 1 
ATOM   879  N  NE2 . GLN A 1 131 ? -14.619 -52.200 1.730   1.00 43.69  ?  131 GLN A NE2 1 
ATOM   880  N  N   . ALA A 1 132 ? -15.977 -47.636 5.629   1.00 33.12  ?  132 ALA A N   1 
ATOM   881  C  CA  . ALA A 1 132 ? -15.670 -46.564 6.576   1.00 30.64  ?  132 ALA A CA  1 
ATOM   882  C  C   . ALA A 1 132 ? -15.105 -47.117 7.876   1.00 32.86  ?  132 ALA A C   1 
ATOM   883  O  O   . ALA A 1 132 ? -14.109 -46.609 8.397   1.00 30.12  ?  132 ALA A O   1 
ATOM   884  C  CB  . ALA A 1 132 ? -16.934 -45.742 6.851   1.00 30.07  ?  132 ALA A CB  1 
ATOM   885  N  N   . HIS A 1 133 ? -15.726 -48.171 8.419   1.00 32.74  ?  133 HIS A N   1 
ATOM   886  C  CA  . HIS A 1 133 ? -15.281 -48.677 9.712   1.00 32.63  ?  133 HIS A CA  1 
ATOM   887  C  C   . HIS A 1 133 ? -13.944 -49.388 9.608   1.00 32.85  ?  133 HIS A C   1 
ATOM   888  O  O   . HIS A 1 133 ? -13.139 -49.330 10.542  1.00 33.67  ?  133 HIS A O   1 
ATOM   889  C  CB  . HIS A 1 133 ? -16.351 -49.602 10.293  1.00 37.18  ?  133 HIS A CB  1 
ATOM   890  C  CG  . HIS A 1 133 ? -17.499 -48.858 10.892  1.00 35.93  ?  133 HIS A CG  1 
ATOM   891  N  ND1 . HIS A 1 133 ? -17.437 -48.270 12.136  1.00 41.00  ?  133 HIS A ND1 1 
ATOM   892  C  CD2 . HIS A 1 133 ? -18.716 -48.547 10.390  1.00 35.05  ?  133 HIS A CD2 1 
ATOM   893  C  CE1 . HIS A 1 133 ? -18.586 -47.669 12.394  1.00 41.78  ?  133 HIS A CE1 1 
ATOM   894  N  NE2 . HIS A 1 133 ? -19.379 -47.824 11.350  1.00 40.29  ?  133 HIS A NE2 1 
ATOM   895  N  N   . GLN A 1 134 ? -13.686 -50.062 8.489   1.00 32.07  ?  134 GLN A N   1 
ATOM   896  C  CA  . GLN A 1 134 ? -12.372 -50.664 8.297   1.00 34.59  ?  134 GLN A CA  1 
ATOM   897  C  C   . GLN A 1 134 ? -11.284 -49.595 8.327   1.00 33.82  ?  134 GLN A C   1 
ATOM   898  O  O   . GLN A 1 134 ? -10.274 -49.728 9.027   1.00 33.02  ?  134 GLN A O   1 
ATOM   899  C  CB  . GLN A 1 134 ? -12.358 -51.429 6.975   1.00 36.66  ?  134 GLN A CB  1 
ATOM   900  C  CG  . GLN A 1 134 ? -11.061 -52.149 6.696   1.00 47.96  ?  134 GLN A CG  1 
ATOM   901  C  CD  . GLN A 1 134 ? -11.120 -52.987 5.424   1.00 56.80  ?  134 GLN A CD  1 
ATOM   902  O  OE1 . GLN A 1 134 ? -11.890 -52.691 4.493   1.00 56.86  ?  134 GLN A OE1 1 
ATOM   903  N  NE2 . GLN A 1 134 ? -10.310 -54.044 5.378   1.00 56.93  ?  134 GLN A NE2 1 
ATOM   904  N  N   . LEU A 1 135 ? -11.496 -48.505 7.592   1.00 33.74  ?  135 LEU A N   1 
ATOM   905  C  CA  . LEU A 1 135 ? -10.530 -47.411 7.587   1.00 32.44  ?  135 LEU A CA  1 
ATOM   906  C  C   . LEU A 1 135 ? -10.386 -46.799 8.976   1.00 30.41  ?  135 LEU A C   1 
ATOM   907  O  O   . LEU A 1 135 ? -9.267  -46.588 9.451   1.00 31.75  ?  135 LEU A O   1 
ATOM   908  C  CB  . LEU A 1 135 ? -10.953 -46.357 6.557   1.00 30.31  ?  135 LEU A CB  1 
ATOM   909  C  CG  . LEU A 1 135 ? -10.907 -46.805 5.088   1.00 31.17  ?  135 LEU A CG  1 
ATOM   910  C  CD1 . LEU A 1 135 ? -11.702 -45.836 4.182   1.00 29.54  ?  135 LEU A CD1 1 
ATOM   911  C  CD2 . LEU A 1 135 ? -9.464  -46.952 4.588   1.00 33.94  ?  135 LEU A CD2 1 
ATOM   912  N  N   . LEU A 1 136 ? -11.503 -46.558 9.669   1.00 32.10  ?  136 LEU A N   1 
ATOM   913  C  CA  . LEU A 1 136 ? -11.423 -45.934 10.992  1.00 31.85  ?  136 LEU A CA  1 
ATOM   914  C  C   . LEU A 1 136 ? -10.809 -46.871 12.018  1.00 33.38  ?  136 LEU A C   1 
ATOM   915  O  O   . LEU A 1 136 ? -10.047 -46.435 12.890  1.00 31.65  ?  136 LEU A O   1 
ATOM   916  C  CB  . LEU A 1 136 ? -12.809 -45.483 11.458  1.00 29.26  ?  136 LEU A CB  1 
ATOM   917  C  CG  . LEU A 1 136 ? -13.383 -44.319 10.635  1.00 33.10  ?  136 LEU A CG  1 
ATOM   918  C  CD1 . LEU A 1 136 ? -14.888 -44.159 10.890  1.00 32.06  ?  136 LEU A CD1 1 
ATOM   919  C  CD2 . LEU A 1 136 ? -12.623 -43.022 10.914  1.00 32.99  ?  136 LEU A CD2 1 
ATOM   920  N  N   . ASP A 1 137 ? -11.128 -48.166 11.941  1.00 34.33  ?  137 ASP A N   1 
ATOM   921  C  CA  . ASP A 1 137 ? -10.520 -49.119 12.870  1.00 34.53  ?  137 ASP A CA  1 
ATOM   922  C  C   . ASP A 1 137 ? -9.003  -49.149 12.721  1.00 35.34  ?  137 ASP A C   1 
ATOM   923  O  O   . ASP A 1 137 ? -8.273  -49.239 13.718  1.00 35.73  ?  137 ASP A O   1 
ATOM   924  C  CB  . ASP A 1 137 ? -11.109 -50.510 12.639  1.00 37.03  ?  137 ASP A CB  1 
ATOM   925  C  CG  . ASP A 1 137 ? -12.542 -50.633 13.182  1.00 43.21  ?  137 ASP A CG  1 
ATOM   926  O  OD1 . ASP A 1 137 ? -12.974 -49.740 13.965  1.00 38.11  ?  137 ASP A OD1 1 
ATOM   927  O  OD2 . ASP A 1 137 ? -13.252 -51.592 12.794  1.00 41.24  ?  137 ASP A OD2 1 
ATOM   928  N  N   . ARG A 1 138 ? -8.514  -49.104 11.478  1.00 34.67  ?  138 ARG A N   1 
ATOM   929  C  CA  . ARG A 1 138 ? -7.077  -49.027 11.243  1.00 38.22  ?  138 ARG A CA  1 
ATOM   930  C  C   . ARG A 1 138 ? -6.474  -47.798 11.913  1.00 34.97  ?  138 ARG A C   1 
ATOM   931  O  O   . ARG A 1 138 ? -5.429  -47.886 12.564  1.00 34.01  ?  138 ARG A O   1 
ATOM   932  C  CB  . ARG A 1 138 ? -6.800  -49.015 9.737   1.00 39.09  ?  138 ARG A CB  1 
ATOM   933  N  N   . LEU A 1 139 ? -7.136  -46.642 11.789  1.00 33.43  ?  139 LEU A N   1 
ATOM   934  C  CA  . LEU A 1 139 ? -6.625  -45.428 12.426  1.00 31.08  ?  139 LEU A CA  1 
ATOM   935  C  C   . LEU A 1 139 ? -6.629  -45.552 13.946  1.00 32.17  ?  139 LEU A C   1 
ATOM   936  O  O   . LEU A 1 139 ? -5.665  -45.157 14.615  1.00 31.15  ?  139 LEU A O   1 
ATOM   937  C  CB  . LEU A 1 139 ? -7.470  -44.223 11.987  1.00 29.12  ?  139 LEU A CB  1 
ATOM   938  C  CG  . LEU A 1 139 ? -7.318  -43.863 10.504  1.00 32.08  ?  139 LEU A CG  1 
ATOM   939  C  CD1 . LEU A 1 139 ? -8.171  -42.630 10.146  1.00 34.51  ?  139 LEU A CD1 1 
ATOM   940  C  CD2 . LEU A 1 139 ? -5.864  -43.642 10.127  1.00 33.86  ?  139 LEU A CD2 1 
ATOM   941  N  N   . ILE A 1 140 ? -7.716  -46.081 14.510  1.00 31.79  ?  140 ILE A N   1 
ATOM   942  C  CA  . ILE A 1 140 ? -7.798  -46.265 15.957  1.00 31.60  ?  140 ILE A CA  1 
ATOM   943  C  C   . ILE A 1 140 ? -6.695  -47.202 16.452  1.00 33.52  ?  140 ILE A C   1 
ATOM   944  O  O   . ILE A 1 140 ? -6.100  -46.972 17.512  1.00 31.62  ?  140 ILE A O   1 
ATOM   945  C  CB  . ILE A 1 140 ? -9.202  -46.774 16.340  1.00 32.67  ?  140 ILE A CB  1 
ATOM   946  C  CG1 . ILE A 1 140 ? -10.230 -45.652 16.157  1.00 35.69  ?  140 ILE A CG1 1 
ATOM   947  C  CG2 . ILE A 1 140 ? -9.214  -47.338 17.768  1.00 35.21  ?  140 ILE A CG2 1 
ATOM   948  C  CD1 . ILE A 1 140 ? -11.658 -46.167 15.907  1.00 36.47  ?  140 ILE A CD1 1 
ATOM   949  N  N   . GLU A 1 141 ? -6.406  -48.276 15.701  1.00 33.50  ?  141 GLU A N   1 
ATOM   950  C  CA  . GLU A 1 141 ? -5.322  -49.184 16.100  1.00 35.57  ?  141 GLU A CA  1 
ATOM   951  C  C   . GLU A 1 141 ? -3.984  -48.455 16.190  1.00 35.90  ?  141 GLU A C   1 
ATOM   952  O  O   . GLU A 1 141 ? -3.226  -48.648 17.146  1.00 37.94  ?  141 GLU A O   1 
ATOM   953  C  CB  . GLU A 1 141 ? -5.207  -50.355 15.118  1.00 39.77  ?  141 GLU A CB  1 
ATOM   954  C  CG  . GLU A 1 141 ? -6.307  -51.399 15.257  1.00 50.67  ?  141 GLU A CG  1 
ATOM   955  C  CD  . GLU A 1 141 ? -6.419  -52.337 14.046  1.00 55.29  ?  141 GLU A CD  1 
ATOM   956  O  OE1 . GLU A 1 141 ? -5.609  -52.210 13.098  1.00 55.92  ?  141 GLU A OE1 1 
ATOM   957  O  OE2 . GLU A 1 141 ? -7.332  -53.205 14.046  1.00 65.09  ?  141 GLU A OE2 1 
ATOM   958  N  N   . GLN A 1 142 ? -3.681  -47.596 15.213  1.00 35.11  ?  142 GLN A N   1 
ATOM   959  C  CA  . GLN A 1 142 ? -2.411  -46.872 15.235  1.00 34.39  ?  142 GLN A CA  1 
ATOM   960  C  C   . GLN A 1 142 ? -2.407  -45.752 16.271  1.00 35.33  ?  142 GLN A C   1 
ATOM   961  O  O   . GLN A 1 142 ? -1.344  -45.402 16.793  1.00 36.98  ?  142 GLN A O   1 
ATOM   962  C  CB  . GLN A 1 142 ? -2.114  -46.310 13.843  1.00 37.72  ?  142 GLN A CB  1 
ATOM   963  C  CG  . GLN A 1 142 ? -1.991  -47.397 12.790  1.00 44.90  ?  142 GLN A CG  1 
ATOM   964  C  CD  . GLN A 1 142 ? -1.866  -46.861 11.377  1.00 48.64  ?  142 GLN A CD  1 
ATOM   965  O  OE1 . GLN A 1 142 ? -1.761  -45.651 11.159  1.00 48.65  ?  142 GLN A OE1 1 
ATOM   966  N  NE2 . GLN A 1 142 ? -1.868  -47.771 10.401  1.00 53.27  ?  142 GLN A NE2 1 
ATOM   967  N  N   . GLY A 1 143 ? -3.566  -45.188 16.590  1.00 32.03  ?  143 GLY A N   1 
ATOM   968  C  CA  . GLY A 1 143 ? -3.649  -44.147 17.591  1.00 29.73  ?  143 GLY A CA  1 
ATOM   969  C  C   . GLY A 1 143 ? -3.495  -42.768 16.967  1.00 32.65  ?  143 GLY A C   1 
ATOM   970  O  O   . GLY A 1 143 ? -2.919  -42.611 15.882  1.00 32.01  ?  143 GLY A O   1 
ATOM   971  N  N   . PRO A 1 144 ? -4.009  -41.742 17.639  1.00 33.09  ?  144 PRO A N   1 
ATOM   972  C  CA  . PRO A 1 144 ? -3.955  -40.378 17.084  1.00 30.42  ?  144 PRO A CA  1 
ATOM   973  C  C   . PRO A 1 144 ? -2.558  -39.795 17.200  1.00 30.95  ?  144 PRO A C   1 
ATOM   974  O  O   . PRO A 1 144 ? -1.753  -40.247 18.030  1.00 29.52  ?  144 PRO A O   1 
ATOM   975  C  CB  . PRO A 1 144 ? -4.957  -39.605 17.957  1.00 32.63  ?  144 PRO A CB  1 
ATOM   976  C  CG  . PRO A 1 144 ? -4.943  -40.348 19.278  1.00 31.95  ?  144 PRO A CG  1 
ATOM   977  C  CD  . PRO A 1 144 ? -4.702  -41.797 18.942  1.00 32.69  ?  144 PRO A CD  1 
ATOM   978  N  N   . PRO A 1 145 ? -2.230  -38.763 16.399  1.00 28.75  ?  145 PRO A N   1 
ATOM   979  C  CA  . PRO A 1 145 ? -3.094  -38.148 15.386  1.00 28.25  ?  145 PRO A CA  1 
ATOM   980  C  C   . PRO A 1 145 ? -3.141  -38.956 14.097  1.00 33.10  ?  145 PRO A C   1 
ATOM   981  O  O   . PRO A 1 145 ? -2.350  -39.892 13.900  1.00 33.69  ?  145 PRO A O   1 
ATOM   982  C  CB  . PRO A 1 145 ? -2.433  -36.773 15.152  1.00 29.59  ?  145 PRO A CB  1 
ATOM   983  C  CG  . PRO A 1 145 ? -0.989  -37.031 15.378  1.00 31.53  ?  145 PRO A CG  1 
ATOM   984  C  CD  . PRO A 1 145 ? -0.888  -38.153 16.410  1.00 31.26  ?  145 PRO A CD  1 
ATOM   985  N  N   . ALA A 1 146 ? -4.075  -38.611 13.222  1.00 30.72  ?  146 ALA A N   1 
ATOM   986  C  CA  . ALA A 1 146 ? -4.141  -39.219 11.906  1.00 31.59  ?  146 ALA A CA  1 
ATOM   987  C  C   . ALA A 1 146 ? -4.486  -38.140 10.896  1.00 33.23  ?  146 ALA A C   1 
ATOM   988  O  O   . ALA A 1 146 ? -5.075  -37.112 11.246  1.00 31.78  ?  146 ALA A O   1 
ATOM   989  C  CB  . ALA A 1 146 ? -5.193  -40.333 11.851  1.00 34.47  ?  146 ALA A CB  1 
ATOM   990  N  N   . ASP A 1 147 ? -4.104  -38.375 9.647   1.00 27.35  ?  147 ASP A N   1 
ATOM   991  C  CA  . ASP A 1 147 ? -4.511  -37.534 8.525   1.00 26.80  ?  147 ASP A CA  1 
ATOM   992  C  C   . ASP A 1 147 ? -5.768  -38.136 7.920   1.00 30.67  ?  147 ASP A C   1 
ATOM   993  O  O   . ASP A 1 147 ? -5.705  -39.178 7.249   1.00 28.64  ?  147 ASP A O   1 
ATOM   994  C  CB  . ASP A 1 147 ? -3.394  -37.443 7.488   1.00 31.47  ?  147 ASP A CB  1 
ATOM   995  C  CG  . ASP A 1 147 ? -3.830  -36.726 6.234   1.00 30.74  ?  147 ASP A CG  1 
ATOM   996  O  OD1 . ASP A 1 147 ? -4.853  -36.013 6.275   1.00 28.58  ?  147 ASP A OD1 1 
ATOM   997  O  OD2 . ASP A 1 147 ? -3.162  -36.898 5.196   1.00 36.67  ?  147 ASP A OD2 1 
ATOM   998  N  N   . LEU A 1 148 ? -6.916  -37.492 8.158   1.00 26.45  ?  148 LEU A N   1 
ATOM   999  C  CA  . LEU A 1 148 ? -8.182  -38.045 7.680   1.00 28.71  ?  148 LEU A CA  1 
ATOM   1000 C  C   . LEU A 1 148 ? -8.377  -37.861 6.178   1.00 29.33  ?  148 LEU A C   1 
ATOM   1001 O  O   . LEU A 1 148 ? -9.344  -38.392 5.628   1.00 32.20  ?  148 LEU A O   1 
ATOM   1002 C  CB  . LEU A 1 148 ? -9.379  -37.421 8.425   1.00 29.69  ?  148 LEU A CB  1 
ATOM   1003 C  CG  . LEU A 1 148 ? -9.615  -37.889 9.870   1.00 29.70  ?  148 LEU A CG  1 
ATOM   1004 C  CD1 . LEU A 1 148 ? -10.970 -37.436 10.401  1.00 28.69  ?  148 LEU A CD1 1 
ATOM   1005 C  CD2 . LEU A 1 148 ? -9.504  -39.399 9.975   1.00 33.79  ?  148 LEU A CD2 1 
ATOM   1006 N  N   . ARG A 1 149 ? -7.494  -37.144 5.486   1.00 27.64  ?  149 ARG A N   1 
ATOM   1007 C  CA  . ARG A 1 149 ? -7.586  -37.157 4.031   1.00 27.31  ?  149 ARG A CA  1 
ATOM   1008 C  C   . ARG A 1 149 ? -6.958  -38.434 3.473   1.00 28.78  ?  149 ARG A C   1 
ATOM   1009 O  O   . ARG A 1 149 ? -7.647  -39.276 2.887   1.00 30.41  ?  149 ARG A O   1 
ATOM   1010 C  CB  . ARG A 1 149 ? -6.929  -35.902 3.432   1.00 29.06  ?  149 ARG A CB  1 
ATOM   1011 C  CG  . ARG A 1 149 ? -6.971  -35.886 1.900   1.00 31.20  ?  149 ARG A CG  1 
ATOM   1012 C  CD  . ARG A 1 149 ? -6.459  -34.586 1.252   1.00 32.99  ?  149 ARG A CD  1 
ATOM   1013 N  NE  . ARG A 1 149 ? -6.376  -34.731 -0.200  1.00 33.84  ?  149 ARG A NE  1 
ATOM   1014 C  CZ  . ARG A 1 149 ? -5.429  -35.429 -0.820  1.00 40.44  ?  149 ARG A CZ  1 
ATOM   1015 N  NH1 . ARG A 1 149 ? -4.456  -36.036 -0.148  1.00 42.29  ?  149 ARG A NH1 1 
ATOM   1016 N  NH2 . ARG A 1 149 ? -5.455  -35.525 -2.142  1.00 43.74  ?  149 ARG A NH2 1 
ATOM   1017 N  N   . ASP A 1 150 ? -5.660  -38.614 3.674   1.00 27.42  ?  150 ASP A N   1 
ATOM   1018 C  CA  . ASP A 1 150 ? -5.003  -39.825 3.166   1.00 30.50  ?  150 ASP A CA  1 
ATOM   1019 C  C   . ASP A 1 150 ? -5.474  -41.094 3.872   1.00 33.50  ?  150 ASP A C   1 
ATOM   1020 O  O   . ASP A 1 150 ? -5.492  -42.167 3.254   1.00 32.67  ?  150 ASP A O   1 
ATOM   1021 C  CB  . ASP A 1 150 ? -3.489  -39.737 3.314   1.00 33.36  ?  150 ASP A CB  1 
ATOM   1022 C  CG  . ASP A 1 150 ? -2.793  -40.918 2.659   1.00 36.63  ?  150 ASP A CG  1 
ATOM   1023 O  OD1 . ASP A 1 150 ? -2.989  -41.105 1.437   1.00 38.58  ?  150 ASP A OD1 1 
ATOM   1024 O  OD2 . ASP A 1 150 ? -2.098  -41.675 3.353   1.00 38.39  ?  150 ASP A OD2 1 
ATOM   1025 N  N   . GLY A 1 151 ? -5.890  -40.969 5.135   1.00 31.60  ?  151 GLY A N   1 
ATOM   1026 C  CA  . GLY A 1 151 ? -6.264  -42.168 5.912   1.00 28.98  ?  151 GLY A CA  1 
ATOM   1027 C  C   . GLY A 1 151 ? -7.743  -42.497 5.837   1.00 33.64  ?  151 GLY A C   1 
ATOM   1028 O  O   . GLY A 1 151 ? -8.111  -43.599 6.295   1.00 31.25  ?  151 GLY A O   1 
ATOM   1029 N  N   . PHE A 1 152 ? -8.573  -41.603 5.291   1.00 27.65  ?  152 PHE A N   1 
ATOM   1030 C  CA  . PHE A 1 152 ? -10.038 -41.877 5.322   1.00 28.28  ?  152 PHE A CA  1 
ATOM   1031 C  C   . PHE A 1 152 ? -10.717 -41.411 4.034   1.00 32.09  ?  152 PHE A C   1 
ATOM   1032 O  O   . PHE A 1 152 ? -11.051 -42.272 3.199   1.00 31.44  ?  152 PHE A O   1 
ATOM   1033 C  CB  . PHE A 1 152 ? -10.665 -41.217 6.554   1.00 30.17  ?  152 PHE A CB  1 
ATOM   1034 C  CG  . PHE A 1 152 ? -12.127 -41.579 6.774   1.00 31.88  ?  152 PHE A CG  1 
ATOM   1035 C  CD1 . PHE A 1 152 ? -12.546 -42.904 6.733   1.00 33.07  ?  152 PHE A CD1 1 
ATOM   1036 C  CD2 . PHE A 1 152 ? -13.078 -40.595 7.017   1.00 30.54  ?  152 PHE A CD2 1 
ATOM   1037 C  CE1 . PHE A 1 152 ? -13.878 -43.232 6.930   1.00 32.88  ?  152 PHE A CE1 1 
ATOM   1038 C  CE2 . PHE A 1 152 ? -14.408 -40.929 7.215   1.00 33.17  ?  152 PHE A CE2 1 
ATOM   1039 C  CZ  . PHE A 1 152 ? -14.805 -42.245 7.172   1.00 31.53  ?  152 PHE A CZ  1 
ATOM   1040 N  N   . THR A 1 153 ? -10.932 -40.102 3.878   1.00 27.15  ?  153 THR A N   1 
ATOM   1041 C  CA  . THR A 1 153 ? -11.692 -39.598 2.708   1.00 27.46  ?  153 THR A CA  1 
ATOM   1042 C  C   . THR A 1 153 ? -11.151 -40.178 1.419   1.00 28.96  ?  153 THR A C   1 
ATOM   1043 O  O   . THR A 1 153 ? -11.950 -40.784 0.677   1.00 29.89  ?  153 THR A O   1 
ATOM   1044 C  CB  . THR A 1 153 ? -11.667 -38.070 2.684   1.00 29.73  ?  153 THR A CB  1 
ATOM   1045 O  OG1 . THR A 1 153 ? -10.340 -37.706 2.317   1.00 28.77  ?  153 THR A OG1 1 
ATOM   1046 C  CG2 . THR A 1 153 ? -12.023 -37.465 4.030   1.00 26.12  ?  153 THR A CG2 1 
ATOM   1047 N  N   . GLU A 1 154 ? -9.853  -40.016 1.148   1.00 27.52  ?  154 GLU A N   1 
ATOM   1048 C  CA  . GLU A 1 154 ? -9.322  -40.442 -0.129  1.00 29.99  ?  154 GLU A CA  1 
ATOM   1049 C  C   . GLU A 1 154 ? -9.571  -41.936 -0.406  1.00 29.27  ?  154 GLU A C   1 
ATOM   1050 O  O   . GLU A 1 154 ? -10.160 -42.264 -1.442  1.00 29.77  ?  154 GLU A O   1 
ATOM   1051 C  CB  . GLU A 1 154 ? -7.838  -40.074 -0.239  1.00 28.30  ?  154 GLU A CB  1 
ATOM   1052 C  CG  . GLU A 1 154 ? -7.592  -38.569 -0.474  1.00 32.62  ?  154 GLU A CG  1 
ATOM   1053 C  CD  . GLU A 1 154 ? -7.912  -38.146 -1.893  1.00 36.88  ?  154 GLU A CD  1 
ATOM   1054 O  OE1 . GLU A 1 154 ? -7.065  -38.390 -2.786  1.00 36.49  ?  154 GLU A OE1 1 
ATOM   1055 O  OE2 . GLU A 1 154 ? -9.003  -37.568 -2.121  1.00 33.14  ?  154 GLU A OE2 1 
ATOM   1056 N  N   . PRO A 1 155 ? -9.147  -42.864 0.464   1.00 28.99  ?  155 PRO A N   1 
ATOM   1057 C  CA  . PRO A 1 155 ? -9.404  -44.287 0.136   1.00 27.44  ?  155 PRO A CA  1 
ATOM   1058 C  C   . PRO A 1 155 ? -10.877 -44.636 0.115   1.00 31.88  ?  155 PRO A C   1 
ATOM   1059 O  O   . PRO A 1 155 ? -11.308 -45.461 -0.706  1.00 30.77  ?  155 PRO A O   1 
ATOM   1060 C  CB  . PRO A 1 155 ? -8.649  -45.047 1.242   1.00 30.82  ?  155 PRO A CB  1 
ATOM   1061 C  CG  . PRO A 1 155 ? -8.432  -44.046 2.347   1.00 30.64  ?  155 PRO A CG  1 
ATOM   1062 C  CD  . PRO A 1 155 ? -8.270  -42.732 1.644   1.00 31.40  ?  155 PRO A CD  1 
ATOM   1063 N  N   . TYR A 1 156 ? -11.678 -44.011 0.986   1.00 27.94  ?  156 TYR A N   1 
ATOM   1064 C  CA  . TYR A 1 156 ? -13.116 -44.269 0.993   1.00 27.70  ?  156 TYR A CA  1 
ATOM   1065 C  C   . TYR A 1 156 ? -13.767 -43.803 -0.302  1.00 32.33  ?  156 TYR A C   1 
ATOM   1066 O  O   . TYR A 1 156 ? -14.589 -44.513 -0.898  1.00 30.16  ?  156 TYR A O   1 
ATOM   1067 C  CB  . TYR A 1 156 ? -13.733 -43.570 2.204   1.00 26.85  ?  156 TYR A CB  1 
ATOM   1068 C  CG  . TYR A 1 156 ? -15.238 -43.597 2.323   1.00 31.19  ?  156 TYR A CG  1 
ATOM   1069 C  CD1 . TYR A 1 156 ? -15.896 -44.725 2.816   1.00 31.43  ?  156 TYR A CD1 1 
ATOM   1070 C  CD2 . TYR A 1 156 ? -16.001 -42.457 2.037   1.00 29.55  ?  156 TYR A CD2 1 
ATOM   1071 C  CE1 . TYR A 1 156 ? -17.284 -44.745 2.965   1.00 29.97  ?  156 TYR A CE1 1 
ATOM   1072 C  CE2 . TYR A 1 156 ? -17.386 -42.456 2.196   1.00 29.23  ?  156 TYR A CE2 1 
ATOM   1073 C  CZ  . TYR A 1 156 ? -18.018 -43.610 2.665   1.00 31.31  ?  156 TYR A CZ  1 
ATOM   1074 O  OH  . TYR A 1 156 ? -19.380 -43.623 2.844   1.00 30.36  ?  156 TYR A OH  1 
ATOM   1075 N  N   . SER A 1 157 ? -13.418 -42.599 -0.752  1.00 29.59  ?  157 SER A N   1 
ATOM   1076 C  CA  . SER A 1 157 ? -13.992 -42.085 -1.990  1.00 26.67  ?  157 SER A CA  1 
ATOM   1077 C  C   . SER A 1 157 ? -13.501 -42.880 -3.193  1.00 31.12  ?  157 SER A C   1 
ATOM   1078 O  O   . SER A 1 157 ? -14.265 -43.130 -4.143  1.00 31.32  ?  157 SER A O   1 
ATOM   1079 C  CB  . SER A 1 157 ? -13.643 -40.598 -2.146  1.00 29.17  ?  157 SER A CB  1 
ATOM   1080 O  OG  . SER A 1 157 ? -14.140 -39.866 -1.022  1.00 29.32  ?  157 SER A OG  1 
ATOM   1081 N  N   . ALA A 1 158 ? -12.225 -43.274 -3.178  1.00 26.74  ?  158 ALA A N   1 
ATOM   1082 C  CA  . ALA A 1 158 ? -11.700 -44.090 -4.267  1.00 30.47  ?  158 ALA A CA  1 
ATOM   1083 C  C   . ALA A 1 158 ? -12.348 -45.471 -4.276  1.00 34.70  ?  158 ALA A C   1 
ATOM   1084 O  O   . ALA A 1 158 ? -12.665 -46.009 -5.342  1.00 33.33  ?  158 ALA A O   1 
ATOM   1085 C  CB  . ALA A 1 158 ? -10.179 -44.229 -4.148  1.00 31.31  ?  158 ALA A CB  1 
ATOM   1086 N  N   . ALA A 1 159 ? -12.528 -46.069 -3.098  1.00 33.68  ?  159 ALA A N   1 
ATOM   1087 C  CA  . ALA A 1 159 ? -13.137 -47.391 -3.045  1.00 32.23  ?  159 ALA A CA  1 
ATOM   1088 C  C   . ALA A 1 159 ? -14.549 -47.358 -3.613  1.00 34.98  ?  159 ALA A C   1 
ATOM   1089 O  O   . ALA A 1 159 ? -14.948 -48.274 -4.343  1.00 34.23  ?  159 ALA A O   1 
ATOM   1090 C  CB  . ALA A 1 159 ? -13.135 -47.919 -1.608  1.00 31.36  ?  159 ALA A CB  1 
ATOM   1091 N  N   . LEU A 1 160 ? -15.315 -46.301 -3.306  1.00 31.46  ?  160 LEU A N   1 
ATOM   1092 C  CA  . LEU A 1 160 ? -16.671 -46.197 -3.822  1.00 32.27  ?  160 LEU A CA  1 
ATOM   1093 C  C   . LEU A 1 160 ? -16.670 -46.144 -5.342  1.00 36.69  ?  160 LEU A C   1 
ATOM   1094 O  O   . LEU A 1 160 ? -17.478 -46.811 -6.002  1.00 35.03  ?  160 LEU A O   1 
ATOM   1095 C  CB  . LEU A 1 160 ? -17.379 -44.962 -3.262  1.00 29.97  ?  160 LEU A CB  1 
ATOM   1096 C  CG  . LEU A 1 160 ? -18.684 -44.633 -4.002  1.00 36.22  ?  160 LEU A CG  1 
ATOM   1097 C  CD1 . LEU A 1 160 ? -19.699 -45.803 -3.916  1.00 36.38  ?  160 LEU A CD1 1 
ATOM   1098 C  CD2 . LEU A 1 160 ? -19.352 -43.347 -3.493  1.00 35.52  ?  160 LEU A CD2 1 
ATOM   1099 N  N   . HIS A 1 161 ? -15.781 -45.338 -5.917  1.00 30.39  ?  161 HIS A N   1 
ATOM   1100 C  CA  . HIS A 1 161 ? -15.819 -45.136 -7.359  1.00 32.41  ?  161 HIS A CA  1 
ATOM   1101 C  C   . HIS A 1 161 ? -15.217 -46.301 -8.125  1.00 31.39  ?  161 HIS A C   1 
ATOM   1102 O  O   . HIS A 1 161 ? -15.643 -46.563 -9.253  1.00 35.33  ?  161 HIS A O   1 
ATOM   1103 C  CB  . HIS A 1 161 ? -15.157 -43.799 -7.691  1.00 31.82  ?  161 HIS A CB  1 
ATOM   1104 C  CG  . HIS A 1 161 ? -16.009 -42.652 -7.261  1.00 30.32  ?  161 HIS A CG  1 
ATOM   1105 N  ND1 . HIS A 1 161 ? -16.001 -42.175 -5.970  1.00 29.64  ?  161 HIS A ND1 1 
ATOM   1106 C  CD2 . HIS A 1 161 ? -16.998 -41.986 -7.906  1.00 30.59  ?  161 HIS A CD2 1 
ATOM   1107 C  CE1 . HIS A 1 161 ? -16.915 -41.224 -5.850  1.00 31.41  ?  161 HIS A CE1 1 
ATOM   1108 N  NE2 . HIS A 1 161 ? -17.540 -41.097 -7.007  1.00 32.56  ?  161 HIS A NE2 1 
ATOM   1109 N  N   . CYS A 1 162 ? -14.263 -47.019 -7.531  1.00 33.09  ?  162 CYS A N   1 
ATOM   1110 C  CA  . CYS A 1 162 ? -13.876 -48.317 -8.082  1.00 34.00  ?  162 CYS A CA  1 
ATOM   1111 C  C   . CYS A 1 162 ? -15.064 -49.279 -8.105  1.00 38.71  ?  162 CYS A C   1 
ATOM   1112 O  O   . CYS A 1 162 ? -15.276 -49.998 -9.090  1.00 36.88  ?  162 CYS A O   1 
ATOM   1113 C  CB  . CYS A 1 162 ? -12.730 -48.914 -7.268  1.00 35.20  ?  162 CYS A CB  1 
ATOM   1114 S  SG  . CYS A 1 162 ? -11.157 -48.036 -7.471  1.00 36.47  ?  162 CYS A SG  1 
ATOM   1115 N  N   . ARG A 1 163 ? -15.856 -49.299 -7.029  1.00 34.92  ?  163 ARG A N   1 
ATOM   1116 C  CA  . ARG A 1 163 ? -17.039 -50.160 -7.005  1.00 39.62  ?  163 ARG A CA  1 
ATOM   1117 C  C   . ARG A 1 163 ? -18.038 -49.747 -8.078  1.00 39.96  ?  163 ARG A C   1 
ATOM   1118 O  O   . ARG A 1 163 ? -18.579 -50.596 -8.798  1.00 38.51  ?  163 ARG A O   1 
ATOM   1119 C  CB  . ARG A 1 163 ? -17.694 -50.128 -5.622  1.00 38.16  ?  163 ARG A CB  1 
ATOM   1120 C  CG  . ARG A 1 163 ? -18.993 -50.942 -5.541  1.00 40.26  ?  163 ARG A CG  1 
ATOM   1121 C  CD  . ARG A 1 163 ? -19.607 -50.903 -4.146  1.00 37.65  ?  163 ARG A CD  1 
ATOM   1122 N  NE  . ARG A 1 163 ? -20.796 -51.746 -4.019  1.00 47.78  ?  163 ARG A NE  1 
ATOM   1123 C  CZ  . ARG A 1 163 ? -20.786 -53.010 -3.602  1.00 46.64  ?  163 ARG A CZ  1 
ATOM   1124 N  NH1 . ARG A 1 163 ? -19.656 -53.641 -3.327  1.00 41.84  ?  163 ARG A NH1 1 
ATOM   1125 N  NH2 . ARG A 1 163 ? -21.942 -53.653 -3.451  1.00 47.42  ?  163 ARG A NH2 1 
ATOM   1126 N  N   . LEU A 1 164 ? -18.271 -48.444 -8.210  1.00 34.07  ?  164 LEU A N   1 
ATOM   1127 C  CA  . LEU A 1 164 ? -19.158 -47.916 -9.245  1.00 36.67  ?  164 LEU A CA  1 
ATOM   1128 C  C   . LEU A 1 164 ? -18.771 -48.401 -10.633 1.00 39.92  ?  164 LEU A C   1 
ATOM   1129 O  O   . LEU A 1 164 ? -19.641 -48.737 -11.448 1.00 38.21  ?  164 LEU A O   1 
ATOM   1130 C  CB  . LEU A 1 164 ? -19.125 -46.394 -9.217  1.00 35.70  ?  164 LEU A CB  1 
ATOM   1131 C  CG  . LEU A 1 164 ? -19.849 -45.642 -8.102  1.00 40.67  ?  164 LEU A CG  1 
ATOM   1132 C  CD1 . LEU A 1 164 ? -19.909 -44.181 -8.525  1.00 43.90  ?  164 LEU A CD1 1 
ATOM   1133 C  CD2 . LEU A 1 164 ? -21.252 -46.198 -7.817  1.00 42.16  ?  164 LEU A CD2 1 
ATOM   1134 N  N   . LEU A 1 165 ? -17.469 -48.389 -10.942 1.00 37.26  ?  165 LEU A N   1 
ATOM   1135 C  CA  . LEU A 1 165 ? -16.997 -48.768 -12.267 1.00 40.92  ?  165 LEU A CA  1 
ATOM   1136 C  C   . LEU A 1 165 ? -16.880 -50.275 -12.440 1.00 40.49  ?  165 LEU A C   1 
ATOM   1137 O  O   . LEU A 1 165 ? -16.898 -50.756 -13.577 1.00 43.12  ?  165 LEU A O   1 
ATOM   1138 C  CB  . LEU A 1 165 ? -15.631 -48.127 -12.554 1.00 37.33  ?  165 LEU A CB  1 
ATOM   1139 C  CG  . LEU A 1 165 ? -15.530 -46.609 -12.757 1.00 37.51  ?  165 LEU A CG  1 
ATOM   1140 C  CD1 . LEU A 1 165 ? -14.220 -46.235 -13.472 1.00 34.40  ?  165 LEU A CD1 1 
ATOM   1141 C  CD2 . LEU A 1 165 ? -16.707 -46.102 -13.514 1.00 42.43  ?  165 LEU A CD2 1 
ATOM   1142 N  N   . GLY A 1 166 ? -16.748 -51.022 -11.346 1.00 41.39  ?  166 GLY A N   1 
ATOM   1143 C  CA  . GLY A 1 166 ? -16.466 -52.443 -11.438 1.00 42.16  ?  166 GLY A CA  1 
ATOM   1144 C  C   . GLY A 1 166 ? -15.008 -52.780 -11.635 1.00 47.94  ?  166 GLY A C   1 
ATOM   1145 O  O   . GLY A 1 166 ? -14.698 -53.744 -12.338 1.00 43.04  ?  166 GLY A O   1 
ATOM   1146 N  N   . ILE A 1 167 ? -14.101 -51.996 -11.061 1.00 39.16  ?  167 ILE A N   1 
ATOM   1147 C  CA  . ILE A 1 167 ? -12.667 -52.262 -11.147 1.00 38.51  ?  167 ILE A CA  1 
ATOM   1148 C  C   . ILE A 1 167 ? -12.162 -52.500 -9.736  1.00 40.76  ?  167 ILE A C   1 
ATOM   1149 O  O   . ILE A 1 167 ? -12.786 -52.059 -8.752  1.00 39.40  ?  167 ILE A O   1 
ATOM   1150 C  CB  . ILE A 1 167 ? -11.907 -51.108 -11.846 1.00 41.36  ?  167 ILE A CB  1 
ATOM   1151 C  CG1 . ILE A 1 167 ? -12.065 -49.799 -11.059 1.00 40.76  ?  167 ILE A CG1 1 
ATOM   1152 C  CG2 . ILE A 1 167 ? -12.387 -50.924 -13.282 1.00 38.46  ?  167 ILE A CG2 1 
ATOM   1153 C  CD1 . ILE A 1 167 ? -11.317 -48.629 -11.667 1.00 39.43  ?  167 ILE A CD1 1 
ATOM   1154 N  N   . PRO A 1 168 ? -11.039 -53.201 -9.581  1.00 40.04  ?  168 PRO A N   1 
ATOM   1155 C  CA  . PRO A 1 168 ? -10.472 -53.382 -8.242  1.00 45.29  ?  168 PRO A CA  1 
ATOM   1156 C  C   . PRO A 1 168 ? -9.892  -52.068 -7.733  1.00 44.02  ?  168 PRO A C   1 
ATOM   1157 O  O   . PRO A 1 168 ? -9.724  -51.098 -8.477  1.00 41.78  ?  168 PRO A O   1 
ATOM   1158 C  CB  . PRO A 1 168 ? -9.380  -54.447 -8.432  1.00 44.63  ?  168 PRO A CB  1 
ATOM   1159 C  CG  . PRO A 1 168 ? -9.381  -54.808 -9.890  1.00 44.21  ?  168 PRO A CG  1 
ATOM   1160 C  CD  . PRO A 1 168 ? -10.176 -53.780 -10.628 1.00 42.58  ?  168 PRO A CD  1 
ATOM   1161 N  N   . THR A 1 169 ? -9.600  -52.047 -6.432  1.00 44.14  ?  169 THR A N   1 
ATOM   1162 C  CA  . THR A 1 169 ? -9.005  -50.892 -5.762  1.00 44.42  ?  169 THR A CA  1 
ATOM   1163 C  C   . THR A 1 169 ? -7.477  -50.931 -5.733  1.00 43.78  ?  169 THR A C   1 
ATOM   1164 O  O   . THR A 1 169 ? -6.865  -50.065 -5.095  1.00 42.22  ?  169 THR A O   1 
ATOM   1165 C  CB  . THR A 1 169 ? -9.513  -50.800 -4.325  1.00 44.76  ?  169 THR A CB  1 
ATOM   1166 O  OG1 . THR A 1 169 ? -9.141  -51.995 -3.621  1.00 43.74  ?  169 THR A OG1 1 
ATOM   1167 C  CG2 . THR A 1 169 ? -11.028 -50.637 -4.295  1.00 40.62  ?  169 THR A CG2 1 
ATOM   1168 N  N   . ASP A 1 170 ? -6.852  -51.916 -6.393  1.00 41.48  ?  170 ASP A N   1 
ATOM   1169 C  CA  . ASP A 1 170 ? -5.408  -52.108 -6.271  1.00 42.74  ?  170 ASP A CA  1 
ATOM   1170 C  C   . ASP A 1 170 ? -4.636  -50.836 -6.604  1.00 40.93  ?  170 ASP A C   1 
ATOM   1171 O  O   . ASP A 1 170 ? -3.623  -50.531 -5.965  1.00 38.07  ?  170 ASP A O   1 
ATOM   1172 C  CB  . ASP A 1 170 ? -4.933  -53.246 -7.177  1.00 45.71  ?  170 ASP A CB  1 
ATOM   1173 C  CG  . ASP A 1 170 ? -5.807  -54.496 -7.082  1.00 51.97  ?  170 ASP A CG  1 
ATOM   1174 O  OD1 . ASP A 1 170 ? -6.383  -54.753 -6.004  1.00 53.70  ?  170 ASP A OD1 1 
ATOM   1175 O  OD2 . ASP A 1 170 ? -5.904  -55.218 -8.096  1.00 56.69  ?  170 ASP A OD2 1 
ATOM   1176 N  N   . ASP A 1 171 ? -5.086  -50.091 -7.609  1.00 37.79  ?  171 ASP A N   1 
ATOM   1177 C  CA  . ASP A 1 171 ? -4.351  -48.928 -8.094  1.00 41.79  ?  171 ASP A CA  1 
ATOM   1178 C  C   . ASP A 1 171 ? -5.002  -47.617 -7.668  1.00 37.56  ?  171 ASP A C   1 
ATOM   1179 O  O   . ASP A 1 171 ? -4.887  -46.616 -8.379  1.00 36.30  ?  171 ASP A O   1 
ATOM   1180 C  CB  . ASP A 1 171 ? -4.230  -48.977 -9.616  1.00 38.61  ?  171 ASP A CB  1 
ATOM   1181 C  CG  . ASP A 1 171 ? -3.752  -50.324 -10.111 1.00 42.65  ?  171 ASP A CG  1 
ATOM   1182 O  OD1 . ASP A 1 171 ? -2.686  -50.764 -9.651  1.00 42.16  ?  171 ASP A OD1 1 
ATOM   1183 O  OD2 . ASP A 1 171 ? -4.462  -50.952 -10.927 1.00 45.44  ?  171 ASP A OD2 1 
ATOM   1184 N  N   . TRP A 1 172 ? -5.694  -47.605 -6.523  1.00 35.24  ?  172 TRP A N   1 
ATOM   1185 C  CA  . TRP A 1 172 ? -6.446  -46.407 -6.143  1.00 36.94  ?  172 TRP A CA  1 
ATOM   1186 C  C   . TRP A 1 172 ? -5.525  -45.208 -5.913  1.00 33.55  ?  172 TRP A C   1 
ATOM   1187 O  O   . TRP A 1 172 ? -5.890  -44.073 -6.241  1.00 33.86  ?  172 TRP A O   1 
ATOM   1188 C  CB  . TRP A 1 172 ? -7.312  -46.672 -4.907  1.00 33.66  ?  172 TRP A CB  1 
ATOM   1189 C  CG  . TRP A 1 172 ? -6.577  -46.768 -3.589  1.00 33.94  ?  172 TRP A CG  1 
ATOM   1190 C  CD1 . TRP A 1 172 ? -6.114  -47.902 -2.988  1.00 36.04  ?  172 TRP A CD1 1 
ATOM   1191 C  CD2 . TRP A 1 172 ? -6.270  -45.688 -2.696  1.00 33.87  ?  172 TRP A CD2 1 
ATOM   1192 N  NE1 . TRP A 1 172 ? -5.533  -47.598 -1.778  1.00 35.77  ?  172 TRP A NE1 1 
ATOM   1193 C  CE2 . TRP A 1 172 ? -5.612  -46.243 -1.580  1.00 35.71  ?  172 TRP A CE2 1 
ATOM   1194 C  CE3 . TRP A 1 172 ? -6.482  -44.301 -2.739  1.00 34.64  ?  172 TRP A CE3 1 
ATOM   1195 C  CZ2 . TRP A 1 172 ? -5.154  -45.460 -0.515  1.00 37.29  ?  172 TRP A CZ2 1 
ATOM   1196 C  CZ3 . TRP A 1 172 ? -6.029  -43.526 -1.679  1.00 31.90  ?  172 TRP A CZ3 1 
ATOM   1197 C  CH2 . TRP A 1 172 ? -5.376  -44.109 -0.583  1.00 34.45  ?  172 TRP A CH2 1 
ATOM   1198 N  N   . ARG A 1 173 ? -4.321  -45.432 -5.376  1.00 32.83  ?  173 ARG A N   1 
ATOM   1199 C  CA  . ARG A 1 173 ? -3.410  -44.301 -5.177  1.00 35.81  ?  173 ARG A CA  1 
ATOM   1200 C  C   . ARG A 1 173 ? -2.991  -43.691 -6.511  1.00 37.24  ?  173 ARG A C   1 
ATOM   1201 O  O   . ARG A 1 173 ? -2.963  -42.459 -6.662  1.00 32.83  ?  173 ARG A O   1 
ATOM   1202 C  CB  . ARG A 1 173 ? -2.176  -44.730 -4.374  1.00 33.43  ?  173 ARG A CB  1 
ATOM   1203 C  CG  . ARG A 1 173 ? -2.481  -45.036 -2.923  1.00 34.84  ?  173 ARG A CG  1 
ATOM   1204 C  CD  . ARG A 1 173 ? -1.226  -45.071 -2.045  1.00 35.58  ?  173 ARG A CD  1 
ATOM   1205 N  NE  . ARG A 1 173 ? -1.572  -45.200 -0.629  1.00 34.49  ?  173 ARG A NE  1 
ATOM   1206 C  CZ  . ARG A 1 173 ? -1.849  -44.173 0.167   1.00 38.98  ?  173 ARG A CZ  1 
ATOM   1207 N  NH1 . ARG A 1 173 ? -1.764  -42.921 -0.262  1.00 34.88  ?  173 ARG A NH1 1 
ATOM   1208 N  NH2 . ARG A 1 173 ? -2.229  -44.406 1.420   1.00 36.41  ?  173 ARG A NH2 1 
ATOM   1209 N  N   . ARG A 1 174 ? -2.655  -44.539 -7.489  1.00 34.32  ?  174 ARG A N   1 
ATOM   1210 C  CA  . ARG A 1 174 ? -2.316  -44.044 -8.821  1.00 32.71  ?  174 ARG A CA  1 
ATOM   1211 C  C   . ARG A 1 174 ? -3.493  -43.280 -9.435  1.00 35.18  ?  174 ARG A C   1 
ATOM   1212 O  O   . ARG A 1 174 ? -3.305  -42.238 -10.082 1.00 32.88  ?  174 ARG A O   1 
ATOM   1213 C  CB  . ARG A 1 174 ? -1.887  -45.226 -9.707  1.00 38.65  ?  174 ARG A CB  1 
ATOM   1214 N  N   . LEU A 1 175 ? -4.716  -43.777 -9.240  1.00 31.02  ?  175 LEU A N   1 
ATOM   1215 C  CA  . LEU A 1 175 ? -5.891  -43.107 -9.813  1.00 31.93  ?  175 LEU A CA  1 
ATOM   1216 C  C   . LEU A 1 175 ? -6.164  -41.762 -9.141  1.00 32.03  ?  175 LEU A C   1 
ATOM   1217 O  O   . LEU A 1 175 ? -6.485  -40.775 -9.819  1.00 30.95  ?  175 LEU A O   1 
ATOM   1218 C  CB  . LEU A 1 175 ? -7.119  -44.011 -9.693  1.00 33.92  ?  175 LEU A CB  1 
ATOM   1219 C  CG  . LEU A 1 175 ? -7.090  -45.241 -10.603 1.00 37.34  ?  175 LEU A CG  1 
ATOM   1220 C  CD1 . LEU A 1 175 ? -8.220  -46.216 -10.234 1.00 36.53  ?  175 LEU A CD1 1 
ATOM   1221 C  CD2 . LEU A 1 175 ? -7.196  -44.802 -12.067 1.00 34.63  ?  175 LEU A CD2 1 
ATOM   1222 N  N   . MET A 1 176 ? -6.052  -41.703 -7.808  1.00 32.24  ?  176 MET A N   1 
ATOM   1223 C  CA  . MET A 1 176 ? -6.225  -40.419 -7.123  1.00 33.52  ?  176 MET A CA  1 
ATOM   1224 C  C   . MET A 1 176 ? -5.108  -39.446 -7.492  1.00 33.38  ?  176 MET A C   1 
ATOM   1225 O  O   . MET A 1 176 ? -5.315  -38.224 -7.467  1.00 30.55  ?  176 MET A O   1 
ATOM   1226 C  CB  . MET A 1 176 ? -6.289  -40.625 -5.597  1.00 32.51  ?  176 MET A CB  1 
ATOM   1227 C  CG  . MET A 1 176 ? -7.448  -41.549 -5.137  1.00 30.61  ?  176 MET A CG  1 
ATOM   1228 S  SD  . MET A 1 176 ? -9.075  -40.997 -5.770  1.00 36.43  ?  176 MET A SD  1 
ATOM   1229 C  CE  . MET A 1 176 ? -9.312  -39.497 -4.858  1.00 36.31  ?  176 MET A CE  1 
ATOM   1230 N  N   . SER A 1 177 ? -3.914  -39.957 -7.829  1.00 31.95  ?  177 SER A N   1 
ATOM   1231 C  CA  . SER A 1 177 ? -2.860  -39.049 -8.268  1.00 32.66  ?  177 SER A CA  1 
ATOM   1232 C  C   . SER A 1 177 ? -3.164  -38.483 -9.647  1.00 33.18  ?  177 SER A C   1 
ATOM   1233 O  O   . SER A 1 177 ? -2.759  -37.354 -9.951  1.00 32.57  ?  177 SER A O   1 
ATOM   1234 C  CB  . SER A 1 177 ? -1.500  -39.746 -8.272  1.00 35.84  ?  177 SER A CB  1 
ATOM   1235 O  OG  . SER A 1 177 ? -0.492  -38.807 -8.639  1.00 38.67  ?  177 SER A OG  1 
ATOM   1236 N  N   . GLY A 1 178 ? -3.863  -39.248 -10.495 1.00 32.29  ?  178 GLY A N   1 
ATOM   1237 C  CA  . GLY A 1 178 ? -4.325  -38.692 -11.758 1.00 32.66  ?  178 GLY A CA  1 
ATOM   1238 C  C   . GLY A 1 178 ? -5.294  -37.543 -11.549 1.00 28.76  ?  178 GLY A C   1 
ATOM   1239 O  O   . GLY A 1 178 ? -5.292  -36.564 -12.302 1.00 30.34  ?  178 GLY A O   1 
ATOM   1240 N  N   . ILE A 1 179 ? -6.118  -37.637 -10.503 1.00 27.87  ?  179 ILE A N   1 
ATOM   1241 C  CA  . ILE A 1 179 ? -7.032  -36.550 -10.151 1.00 29.81  ?  179 ILE A CA  1 
ATOM   1242 C  C   . ILE A 1 179 ? -6.257  -35.297 -9.741  1.00 30.01  ?  179 ILE A C   1 
ATOM   1243 O  O   . ILE A 1 179 ? -6.642  -34.169 -10.080 1.00 27.81  ?  179 ILE A O   1 
ATOM   1244 C  CB  . ILE A 1 179 ? -7.991  -37.039 -9.048  1.00 29.20  ?  179 ILE A CB  1 
ATOM   1245 C  CG1 . ILE A 1 179 ? -9.107  -37.884 -9.676  1.00 30.47  ?  179 ILE A CG1 1 
ATOM   1246 C  CG2 . ILE A 1 179 ? -8.577  -35.877 -8.251  1.00 31.70  ?  179 ILE A CG2 1 
ATOM   1247 C  CD1 . ILE A 1 179 ? -9.990  -38.616 -8.636  1.00 33.75  ?  179 ILE A CD1 1 
ATOM   1248 N  N   . ASP A 1 180 ? -5.134  -35.477 -9.036  1.00 29.83  ?  180 ASP A N   1 
ATOM   1249 C  CA  . ASP A 1 180 ? -4.309  -34.347 -8.610  1.00 29.88  ?  180 ASP A CA  1 
ATOM   1250 C  C   . ASP A 1 180 ? -3.776  -33.524 -9.776  1.00 31.30  ?  180 ASP A C   1 
ATOM   1251 O  O   . ASP A 1 180 ? -3.414  -32.357 -9.576  1.00 30.58  ?  180 ASP A O   1 
ATOM   1252 C  CB  . ASP A 1 180 ? -3.110  -34.836 -7.802  1.00 29.23  ?  180 ASP A CB  1 
ATOM   1253 C  CG  . ASP A 1 180 ? -3.481  -35.278 -6.406  1.00 33.99  ?  180 ASP A CG  1 
ATOM   1254 O  OD1 . ASP A 1 180 ? -4.550  -34.880 -5.892  1.00 33.97  ?  180 ASP A OD1 1 
ATOM   1255 O  OD2 . ASP A 1 180 ? -2.681  -36.027 -5.821  1.00 36.88  ?  180 ASP A OD2 1 
ATOM   1256 N  N   . VAL A 1 181 ? -3.648  -34.120 -10.957 1.00 29.21  ?  181 VAL A N   1 
ATOM   1257 C  CA  . VAL A 1 181 ? -3.216  -33.410 -12.152 1.00 27.52  ?  181 VAL A CA  1 
ATOM   1258 C  C   . VAL A 1 181 ? -4.408  -32.939 -12.975 1.00 28.87  ?  181 VAL A C   1 
ATOM   1259 O  O   . VAL A 1 181 ? -4.431  -31.800 -13.450 1.00 27.84  ?  181 VAL A O   1 
ATOM   1260 C  CB  . VAL A 1 181 ? -2.277  -34.313 -12.988 1.00 31.18  ?  181 VAL A CB  1 
ATOM   1261 C  CG1 . VAL A 1 181 ? -1.981  -33.668 -14.363 1.00 29.67  ?  181 VAL A CG1 1 
ATOM   1262 C  CG2 . VAL A 1 181 ? -0.979  -34.594 -12.224 1.00 28.56  ?  181 VAL A CG2 1 
ATOM   1263 N  N   . ALA A 1 182 ? -5.414  -33.807 -13.125 1.00 26.53  ?  182 ALA A N   1 
ATOM   1264 C  CA  . ALA A 1 182 ? -6.536  -33.527 -14.011 1.00 27.89  ?  182 ALA A CA  1 
ATOM   1265 C  C   . ALA A 1 182 ? -7.340  -32.312 -13.556 1.00 30.24  ?  182 ALA A C   1 
ATOM   1266 O  O   . ALA A 1 182 ? -7.878  -31.579 -14.393 1.00 30.84  ?  182 ALA A O   1 
ATOM   1267 C  CB  . ALA A 1 182 ? -7.430  -34.771 -14.095 1.00 27.59  ?  182 ALA A CB  1 
ATOM   1268 N  N   . PHE A 1 183 ? -7.419  -32.057 -12.247 1.00 27.07  ?  183 PHE A N   1 
ATOM   1269 C  CA  . PHE A 1 183 ? -8.253  -30.969 -11.745 1.00 28.41  ?  183 PHE A CA  1 
ATOM   1270 C  C   . PHE A 1 183 ? -7.444  -29.731 -11.350 1.00 30.17  ?  183 PHE A C   1 
ATOM   1271 O  O   . PHE A 1 183 ? -7.945  -28.866 -10.615 1.00 27.60  ?  183 PHE A O   1 
ATOM   1272 C  CB  . PHE A 1 183 ? -9.121  -31.479 -10.592 1.00 25.52  ?  183 PHE A CB  1 
ATOM   1273 C  CG  . PHE A 1 183 ? -10.180 -32.469 -11.048 1.00 30.91  ?  183 PHE A CG  1 
ATOM   1274 C  CD1 . PHE A 1 183 ? -9.868  -33.815 -11.230 1.00 31.61  ?  183 PHE A CD1 1 
ATOM   1275 C  CD2 . PHE A 1 183 ? -11.462 -32.040 -11.343 1.00 31.97  ?  183 PHE A CD2 1 
ATOM   1276 C  CE1 . PHE A 1 183 ? -10.843 -34.723 -11.681 1.00 32.55  ?  183 PHE A CE1 1 
ATOM   1277 C  CE2 . PHE A 1 183 ? -12.441 -32.940 -11.782 1.00 31.76  ?  183 PHE A CE2 1 
ATOM   1278 C  CZ  . PHE A 1 183 ? -12.127 -34.268 -11.961 1.00 30.78  ?  183 PHE A CZ  1 
ATOM   1279 N  N   . ILE A 1 184 ? -6.214  -29.619 -11.852 1.00 27.05  ?  184 ILE A N   1 
ATOM   1280 C  CA  . ILE A 1 184 ? -5.425  -28.403 -11.698 1.00 26.03  ?  184 ILE A CA  1 
ATOM   1281 C  C   . ILE A 1 184 ? -6.068  -27.256 -12.472 1.00 30.40  ?  184 ILE A C   1 
ATOM   1282 O  O   . ILE A 1 184 ? -6.561  -27.438 -13.600 1.00 27.13  ?  184 ILE A O   1 
ATOM   1283 C  CB  . ILE A 1 184 ? -3.985  -28.648 -12.185 1.00 26.95  ?  184 ILE A CB  1 
ATOM   1284 C  CG1 . ILE A 1 184 ? -3.176  -29.419 -11.146 1.00 28.71  ?  184 ILE A CG1 1 
ATOM   1285 C  CG2 . ILE A 1 184 ? -3.276  -27.339 -12.554 1.00 27.28  ?  184 ILE A CG2 1 
ATOM   1286 C  CD1 . ILE A 1 184 ? -1.764  -29.762 -11.636 1.00 29.66  ?  184 ILE A CD1 1 
ATOM   1287 N  N   . THR A 1 185 ? -6.032  -26.055 -11.879 1.00 27.50  ?  185 THR A N   1 
ATOM   1288 C  CA  . THR A 1 185 ? -6.434  -24.817 -12.543 1.00 28.82  ?  185 THR A CA  1 
ATOM   1289 C  C   . THR A 1 185 ? -5.178  -24.060 -12.945 1.00 30.90  ?  185 THR A C   1 
ATOM   1290 O  O   . THR A 1 185 ? -4.393  -23.666 -12.077 1.00 29.39  ?  185 THR A O   1 
ATOM   1291 C  CB  . THR A 1 185 ? -7.302  -23.942 -11.639 1.00 30.28  ?  185 THR A CB  1 
ATOM   1292 O  OG1 . THR A 1 185 ? -6.600  -23.654 -10.416 1.00 27.82  ?  185 THR A OG1 1 
ATOM   1293 C  CG2 . THR A 1 185 ? -8.629  -24.630 -11.317 1.00 29.98  ?  185 THR A CG2 1 
ATOM   1294 N  N   . SER A 1 186 ? -4.972  -23.888 -14.255 1.00 29.71  ?  186 SER A N   1 
ATOM   1295 C  CA  . SER A 1 186 ? -3.763  -23.245 -14.767 1.00 27.78  ?  186 SER A CA  1 
ATOM   1296 C  C   . SER A 1 186 ? -4.131  -22.085 -15.679 1.00 29.99  ?  186 SER A C   1 
ATOM   1297 O  O   . SER A 1 186 ? -5.093  -22.187 -16.457 1.00 31.40  ?  186 SER A O   1 
ATOM   1298 C  CB  . SER A 1 186 ? -2.912  -24.264 -15.542 1.00 29.81  ?  186 SER A CB  1 
ATOM   1299 O  OG  . SER A 1 186 ? -1.715  -23.671 -16.031 1.00 31.23  ?  186 SER A OG  1 
ATOM   1300 N  N   . PRO A 1 187 ? -3.390  -20.980 -15.625 1.00 30.99  ?  187 PRO A N   1 
ATOM   1301 C  CA  . PRO A 1 187 ? -3.666  -19.870 -16.551 1.00 33.62  ?  187 PRO A CA  1 
ATOM   1302 C  C   . PRO A 1 187 ? -3.537  -20.249 -18.012 1.00 35.80  ?  187 PRO A C   1 
ATOM   1303 O  O   . PRO A 1 187 ? -4.275  -19.699 -18.837 1.00 36.08  ?  187 PRO A O   1 
ATOM   1304 C  CB  . PRO A 1 187 ? -2.621  -18.817 -16.151 1.00 34.07  ?  187 PRO A CB  1 
ATOM   1305 C  CG  . PRO A 1 187 ? -2.341  -19.108 -14.718 1.00 36.82  ?  187 PRO A CG  1 
ATOM   1306 C  CD  . PRO A 1 187 ? -2.402  -20.603 -14.594 1.00 33.51  ?  187 PRO A CD  1 
ATOM   1307 N  N   . ARG A 1 188 ? -2.613  -21.151 -18.357 1.00 30.65  ?  188 ARG A N   1 
ATOM   1308 C  CA  . ARG A 1 188 ? -2.399  -21.600 -19.727 1.00 31.94  ?  188 ARG A CA  1 
ATOM   1309 C  C   . ARG A 1 188 ? -2.356  -23.120 -19.754 1.00 34.95  ?  188 ARG A C   1 
ATOM   1310 O  O   . ARG A 1 188 ? -2.068  -23.753 -18.736 1.00 30.81  ?  188 ARG A O   1 
ATOM   1311 C  CB  . ARG A 1 188 ? -1.089  -21.047 -20.299 1.00 35.75  ?  188 ARG A CB  1 
ATOM   1312 C  CG  . ARG A 1 188 ? -1.037  -19.528 -20.355 1.00 38.30  ?  188 ARG A CG  1 
ATOM   1313 C  CD  . ARG A 1 188 ? -1.839  -19.025 -21.555 1.00 42.62  ?  188 ARG A CD  1 
ATOM   1314 N  NE  . ARG A 1 188 ? -1.826  -17.567 -21.669 1.00 49.23  ?  188 ARG A NE  1 
ATOM   1315 C  CZ  . ARG A 1 188 ? -2.626  -16.739 -21.004 1.00 52.48  ?  188 ARG A CZ  1 
ATOM   1316 N  NH1 . ARG A 1 188 ? -3.556  -17.187 -20.171 1.00 43.09  ?  188 ARG A NH1 1 
ATOM   1317 N  NH2 . ARG A 1 188 ? -2.507  -15.427 -21.199 1.00 51.32  ?  188 ARG A NH2 1 
ATOM   1318 N  N   . THR A 1 189 ? -2.633  -23.709 -20.926 1.00 31.36  ?  189 THR A N   1 
ATOM   1319 C  CA  . THR A 1 189 ? -2.527  -25.160 -21.046 1.00 35.00  ?  189 THR A CA  1 
ATOM   1320 C  C   . THR A 1 189 ? -1.130  -25.605 -20.643 1.00 32.77  ?  189 THR A C   1 
ATOM   1321 O  O   . THR A 1 189 ? -0.142  -24.897 -20.870 1.00 32.50  ?  189 THR A O   1 
ATOM   1322 C  CB  . THR A 1 189 ? -2.802  -25.640 -22.476 1.00 36.09  ?  189 THR A CB  1 
ATOM   1323 O  OG1 . THR A 1 189 ? -1.866  -25.008 -23.359 1.00 45.49  ?  189 THR A OG1 1 
ATOM   1324 C  CG2 . THR A 1 189 ? -4.210  -25.316 -22.913 1.00 40.66  ?  189 THR A CG2 1 
ATOM   1325 N  N   . PHE A 1 190 ? -1.048  -26.780 -20.016 1.00 30.99  ?  190 PHE A N   1 
ATOM   1326 C  CA  . PHE A 1 190 ? 0.272   -27.271 -19.536 1.00 33.29  ?  190 PHE A CA  1 
ATOM   1327 C  C   . PHE A 1 190 ? 0.538   -28.657 -20.120 1.00 34.77  ?  190 PHE A C   1 
ATOM   1328 O  O   . PHE A 1 190 ? -0.348  -29.539 -20.049 1.00 30.67  ?  190 PHE A O   1 
ATOM   1329 C  CB  . PHE A 1 190 ? 0.340   -27.249 -18.003 1.00 31.51  ?  190 PHE A CB  1 
ATOM   1330 C  CG  . PHE A 1 190 ? -0.696  -28.083 -17.260 1.00 32.36  ?  190 PHE A CG  1 
ATOM   1331 C  CD1 . PHE A 1 190 ? -1.965  -27.578 -16.997 1.00 30.03  ?  190 PHE A CD1 1 
ATOM   1332 C  CD2 . PHE A 1 190 ? -0.392  -29.361 -16.806 1.00 30.08  ?  190 PHE A CD2 1 
ATOM   1333 C  CE1 . PHE A 1 190 ? -2.901  -28.335 -16.313 1.00 31.15  ?  190 PHE A CE1 1 
ATOM   1334 C  CE2 . PHE A 1 190 ? -1.333  -30.114 -16.122 1.00 32.49  ?  190 PHE A CE2 1 
ATOM   1335 C  CZ  . PHE A 1 190 ? -2.585  -29.600 -15.877 1.00 32.16  ?  190 PHE A CZ  1 
ATOM   1336 N  N   . GLU A 1 191 ? 1.722   -28.923 -20.638 1.00 35.05  ?  191 GLU A N   1 
ATOM   1337 C  CA  . GLU A 1 191 ? 1.979   -30.312 -21.081 1.00 37.43  ?  191 GLU A CA  1 
ATOM   1338 C  C   . GLU A 1 191 ? 1.563   -31.126 -19.859 1.00 34.52  ?  191 GLU A C   1 
ATOM   1339 O  O   . GLU A 1 191 ? 1.535   -30.573 -18.753 1.00 37.89  ?  191 GLU A O   1 
ATOM   1340 C  CB  . GLU A 1 191 ? 3.419   -30.499 -21.549 1.00 35.56  ?  191 GLU A CB  1 
ATOM   1341 C  CG  . GLU A 1 191 ? 3.702   -31.841 -22.217 1.00 38.63  ?  191 GLU A CG  1 
ATOM   1342 C  CD  . GLU A 1 191 ? 5.180   -32.078 -22.481 1.00 40.15  ?  191 GLU A CD  1 
ATOM   1343 O  OE1 . GLU A 1 191 ? 5.493   -32.927 -23.333 1.00 39.08  ?  191 GLU A OE1 1 
ATOM   1344 O  OE2 . GLU A 1 191 ? 6.018   -31.414 -21.839 1.00 38.77  ?  191 GLU A OE2 1 
ATOM   1345 N  N   . GLY A 1 192 ? 1.257   -32.389 -20.017 1.00 32.64  ?  192 GLY A N   1 
ATOM   1346 C  CA  . GLY A 1 192 ? 0.876   -33.082 -18.771 1.00 45.99  ?  192 GLY A CA  1 
ATOM   1347 C  C   . GLY A 1 192 ? -0.587  -33.330 -18.569 1.00 34.55  ?  192 GLY A C   1 
ATOM   1348 O  O   . GLY A 1 192 ? -0.924  -34.448 -18.220 1.00 33.44  ?  192 GLY A O   1 
ATOM   1349 N  N   . SER A 1 193 ? -1.414  -32.319 -18.810 1.00 33.66  ?  193 SER A N   1 
ATOM   1350 C  CA  . SER A 1 193 ? -2.883  -32.501 -18.751 1.00 32.73  ?  193 SER A CA  1 
ATOM   1351 C  C   . SER A 1 193 ? -3.267  -33.586 -19.770 1.00 32.88  ?  193 SER A C   1 
ATOM   1352 O  O   . SER A 1 193 ? -3.916  -34.561 -19.385 1.00 32.31  ?  193 SER A O   1 
ATOM   1353 C  CB  . SER A 1 193 ? -3.611  -31.201 -18.980 1.00 34.03  ?  193 SER A CB  1 
ATOM   1354 O  OG  . SER A 1 193 ? -3.307  -30.643 -20.246 1.00 38.59  ?  193 SER A OG  1 
ATOM   1355 N  N   . ALA A 1 194 ? -2.830  -33.428 -21.016 1.00 36.02  ?  194 ALA A N   1 
ATOM   1356 C  CA  . ALA A 1 194 ? -3.164  -34.407 -22.074 1.00 34.91  ?  194 ALA A CA  1 
ATOM   1357 C  C   . ALA A 1 194 ? -2.482  -35.741 -21.771 1.00 34.60  ?  194 ALA A C   1 
ATOM   1358 O  O   . ALA A 1 194 ? -3.152  -36.774 -21.840 1.00 36.38  ?  194 ALA A O   1 
ATOM   1359 C  CB  . ALA A 1 194 ? -2.761  -33.880 -23.422 1.00 40.47  ?  194 ALA A CB  1 
ATOM   1360 N  N   . VAL A 1 195 ? -1.190  -35.697 -21.446 1.00 32.37  ?  195 VAL A N   1 
ATOM   1361 C  CA  . VAL A 1 195 ? -0.507  -36.957 -21.151 1.00 32.51  ?  195 VAL A CA  1 
ATOM   1362 C  C   . VAL A 1 195 ? -1.236  -37.681 -20.036 1.00 33.38  ?  195 VAL A C   1 
ATOM   1363 O  O   . VAL A 1 195 ? -1.480  -38.893 -20.113 1.00 31.80  ?  195 VAL A O   1 
ATOM   1364 C  CB  . VAL A 1 195 ? 0.977   -36.716 -20.795 1.00 32.70  ?  195 VAL A CB  1 
ATOM   1365 C  CG1 . VAL A 1 195 ? 1.673   -38.002 -20.469 1.00 33.26  ?  195 VAL A CG1 1 
ATOM   1366 C  CG2 . VAL A 1 195 ? 1.733   -35.979 -21.938 1.00 31.37  ?  195 VAL A CG2 1 
ATOM   1367 N  N   . ASN A 1 196 ? -1.644  -36.932 -19.004 1.00 31.32  ?  196 ASN A N   1 
ATOM   1368 C  CA  . ASN A 1 196 ? -2.334  -37.517 -17.858 1.00 32.09  ?  196 ASN A CA  1 
ATOM   1369 C  C   . ASN A 1 196 ? -3.686  -38.093 -18.264 1.00 32.49  ?  196 ASN A C   1 
ATOM   1370 O  O   . ASN A 1 196 ? -4.099  -39.155 -17.779 1.00 32.71  ?  196 ASN A O   1 
ATOM   1371 C  CB  . ASN A 1 196 ? -2.527  -36.436 -16.789 1.00 31.57  ?  196 ASN A CB  1 
ATOM   1372 C  CG  . ASN A 1 196 ? -3.126  -36.975 -15.518 1.00 33.56  ?  196 ASN A CG  1 
ATOM   1373 O  OD1 . ASN A 1 196 ? -2.485  -37.725 -14.797 1.00 34.16  ?  196 ASN A OD1 1 
ATOM   1374 N  ND2 . ASN A 1 196 ? -4.374  -36.597 -15.236 1.00 33.19  ?  196 ASN A ND2 1 
ATOM   1375 N  N   . TRP A 1 197 ? -4.402  -37.388 -19.134 1.00 30.58  ?  197 TRP A N   1 
ATOM   1376 C  CA  . TRP A 1 197 ? -5.710  -37.864 -19.559 1.00 33.82  ?  197 TRP A CA  1 
ATOM   1377 C  C   . TRP A 1 197 ? -5.578  -39.184 -20.312 1.00 36.08  ?  197 TRP A C   1 
ATOM   1378 O  O   . TRP A 1 197 ? -6.227  -40.177 -19.966 1.00 36.38  ?  197 TRP A O   1 
ATOM   1379 C  CB  . TRP A 1 197 ? -6.392  -36.806 -20.425 1.00 34.41  ?  197 TRP A CB  1 
ATOM   1380 C  CG  . TRP A 1 197 ? -7.706  -37.288 -20.930 1.00 39.28  ?  197 TRP A CG  1 
ATOM   1381 C  CD1 . TRP A 1 197 ? -7.976  -37.778 -22.172 1.00 40.95  ?  197 TRP A CD1 1 
ATOM   1382 C  CD2 . TRP A 1 197 ? -8.933  -37.341 -20.194 1.00 39.25  ?  197 TRP A CD2 1 
ATOM   1383 N  NE1 . TRP A 1 197 ? -9.309  -38.133 -22.258 1.00 44.77  ?  197 TRP A NE1 1 
ATOM   1384 C  CE2 . TRP A 1 197 ? -9.916  -37.875 -21.056 1.00 42.51  ?  197 TRP A CE2 1 
ATOM   1385 C  CE3 . TRP A 1 197 ? -9.297  -36.992 -18.892 1.00 43.84  ?  197 TRP A CE3 1 
ATOM   1386 C  CZ2 . TRP A 1 197 ? -11.234 -38.070 -20.657 1.00 46.26  ?  197 TRP A CZ2 1 
ATOM   1387 C  CZ3 . TRP A 1 197 ? -10.623 -37.188 -18.493 1.00 45.30  ?  197 TRP A CZ3 1 
ATOM   1388 C  CH2 . TRP A 1 197 ? -11.566 -37.721 -19.375 1.00 44.70  ?  197 TRP A CH2 1 
ATOM   1389 N  N   . TYR A 1 198 ? -4.711  -39.224 -21.326 1.00 33.01  ?  198 TYR A N   1 
ATOM   1390 C  CA  . TYR A 1 198 ? -4.579  -40.451 -22.114 1.00 38.34  ?  198 TYR A CA  1 
ATOM   1391 C  C   . TYR A 1 198 ? -3.988  -41.591 -21.291 1.00 38.42  ?  198 TYR A C   1 
ATOM   1392 O  O   . TYR A 1 198 ? -4.266  -42.768 -21.566 1.00 36.32  ?  198 TYR A O   1 
ATOM   1393 C  CB  . TYR A 1 198 ? -3.753  -40.169 -23.378 1.00 39.02  ?  198 TYR A CB  1 
ATOM   1394 C  CG  . TYR A 1 198 ? -4.565  -39.330 -24.338 1.00 43.61  ?  198 TYR A CG  1 
ATOM   1395 C  CD1 . TYR A 1 198 ? -5.833  -39.747 -24.734 1.00 44.99  ?  198 TYR A CD1 1 
ATOM   1396 C  CD2 . TYR A 1 198 ? -4.114  -38.096 -24.782 1.00 44.81  ?  198 TYR A CD2 1 
ATOM   1397 C  CE1 . TYR A 1 198 ? -6.615  -38.978 -25.580 1.00 51.28  ?  198 TYR A CE1 1 
ATOM   1398 C  CE2 . TYR A 1 198 ? -4.896  -37.314 -25.632 1.00 49.07  ?  198 TYR A CE2 1 
ATOM   1399 C  CZ  . TYR A 1 198 ? -6.142  -37.770 -26.024 1.00 50.55  ?  198 TYR A CZ  1 
ATOM   1400 O  OH  . TYR A 1 198 ? -6.927  -37.016 -26.865 1.00 63.58  ?  198 TYR A OH  1 
ATOM   1401 N  N   . LYS A 1 199 ? -3.209  -41.266 -20.259 1.00 33.01  ?  199 LYS A N   1 
ATOM   1402 C  CA  . LYS A 1 199 ? -2.691  -42.296 -19.361 1.00 33.24  ?  199 LYS A CA  1 
ATOM   1403 C  C   . LYS A 1 199 ? -3.824  -43.069 -18.693 1.00 38.38  ?  199 LYS A C   1 
ATOM   1404 O  O   . LYS A 1 199 ? -3.851  -44.307 -18.705 1.00 33.64  ?  199 LYS A O   1 
ATOM   1405 C  CB  . LYS A 1 199 ? -1.804  -41.655 -18.298 1.00 31.72  ?  199 LYS A CB  1 
ATOM   1406 C  CG  . LYS A 1 199 ? -1.272  -42.626 -17.256 1.00 37.05  ?  199 LYS A CG  1 
ATOM   1407 C  CD  . LYS A 1 199 ? -0.609  -41.868 -16.108 1.00 34.50  ?  199 LYS A CD  1 
ATOM   1408 C  CE  . LYS A 1 199 ? -0.288  -42.782 -14.942 1.00 36.44  ?  199 LYS A CE  1 
ATOM   1409 N  NZ  . LYS A 1 199 ? 0.698   -42.162 -14.014 1.00 32.72  ?  199 LYS A NZ  1 
ATOM   1410 N  N   . ASP A 1 200 ? -4.757  -42.354 -18.074 1.00 33.06  ?  200 ASP A N   1 
ATOM   1411 C  CA  . ASP A 1 200 ? -5.814  -43.048 -17.358 1.00 34.30  ?  200 ASP A CA  1 
ATOM   1412 C  C   . ASP A 1 200 ? -6.960  -43.456 -18.271 1.00 35.65  ?  200 ASP A C   1 
ATOM   1413 O  O   . ASP A 1 200 ? -7.725  -44.356 -17.910 1.00 32.68  ?  200 ASP A O   1 
ATOM   1414 C  CB  . ASP A 1 200 ? -6.302  -42.180 -16.196 1.00 35.10  ?  200 ASP A CB  1 
ATOM   1415 C  CG  . ASP A 1 200 ? -5.337  -42.227 -15.001 1.00 37.42  ?  200 ASP A CG  1 
ATOM   1416 O  OD1 . ASP A 1 200 ? -4.431  -43.096 -14.987 1.00 39.55  ?  200 ASP A OD1 1 
ATOM   1417 O  OD2 . ASP A 1 200 ? -5.481  -41.407 -14.074 1.00 40.20  ?  200 ASP A OD2 1 
ATOM   1418 N  N   . LEU A 1 201 ? -7.096  -42.820 -19.438 1.00 33.31  ?  201 LEU A N   1 
ATOM   1419 C  CA  . LEU A 1 201 ? -8.016  -43.349 -20.439 1.00 38.31  ?  201 LEU A CA  1 
ATOM   1420 C  C   . LEU A 1 201 ? -7.582  -44.743 -20.877 1.00 38.60  ?  201 LEU A C   1 
ATOM   1421 O  O   . LEU A 1 201 ? -8.413  -45.654 -20.996 1.00 38.73  ?  201 LEU A O   1 
ATOM   1422 C  CB  . LEU A 1 201 ? -8.092  -42.406 -21.640 1.00 38.37  ?  201 LEU A CB  1 
ATOM   1423 C  CG  . LEU A 1 201 ? -9.172  -42.712 -22.682 1.00 42.48  ?  201 LEU A CG  1 
ATOM   1424 C  CD1 . LEU A 1 201 ? -10.564 -42.456 -22.121 1.00 41.98  ?  201 LEU A CD1 1 
ATOM   1425 C  CD2 . LEU A 1 201 ? -8.937  -41.889 -23.957 1.00 41.02  ?  201 LEU A CD2 1 
ATOM   1426 N  N   . GLY A 1 202 ? -6.276  -44.932 -21.094 1.00 35.66  ?  202 GLY A N   1 
ATOM   1427 C  CA  . GLY A 1 202 ? -5.770  -46.256 -21.433 1.00 38.75  ?  202 GLY A CA  1 
ATOM   1428 C  C   . GLY A 1 202 ? -5.974  -47.258 -20.313 1.00 40.76  ?  202 GLY A C   1 
ATOM   1429 O  O   . GLY A 1 202 ? -6.256  -48.436 -20.558 1.00 37.70  ?  202 GLY A O   1 
ATOM   1430 N  N   . TYR A 1 203 ? -5.821  -46.806 -19.065 1.00 37.28  ?  203 TYR A N   1 
ATOM   1431 C  CA  . TYR A 1 203 ? -6.096  -47.668 -17.925 1.00 38.08  ?  203 TYR A CA  1 
ATOM   1432 C  C   . TYR A 1 203 ? -7.525  -48.186 -17.975 1.00 39.42  ?  203 TYR A C   1 
ATOM   1433 O  O   . TYR A 1 203 ? -7.774  -49.372 -17.748 1.00 40.59  ?  203 TYR A O   1 
ATOM   1434 C  CB  . TYR A 1 203 ? -5.859  -46.902 -16.624 1.00 37.19  ?  203 TYR A CB  1 
ATOM   1435 C  CG  . TYR A 1 203 ? -6.087  -47.730 -15.390 1.00 36.58  ?  203 TYR A CG  1 
ATOM   1436 C  CD1 . TYR A 1 203 ? -7.352  -47.839 -14.821 1.00 37.89  ?  203 TYR A CD1 1 
ATOM   1437 C  CD2 . TYR A 1 203 ? -5.034  -48.403 -14.788 1.00 38.96  ?  203 TYR A CD2 1 
ATOM   1438 C  CE1 . TYR A 1 203 ? -7.553  -48.602 -13.693 1.00 39.53  ?  203 TYR A CE1 1 
ATOM   1439 C  CE2 . TYR A 1 203 ? -5.225  -49.160 -13.658 1.00 38.81  ?  203 TYR A CE2 1 
ATOM   1440 C  CZ  . TYR A 1 203 ? -6.483  -49.251 -13.116 1.00 38.21  ?  203 TYR A CZ  1 
ATOM   1441 O  OH  . TYR A 1 203 ? -6.661  -50.007 -11.986 1.00 40.03  ?  203 TYR A OH  1 
ATOM   1442 N  N   . MET A 1 204 ? -8.480  -47.294 -18.253 1.00 34.12  ?  204 MET A N   1 
ATOM   1443 C  CA  . MET A 1 204 ? -9.889  -47.682 -18.297 1.00 39.40  ?  204 MET A CA  1 
ATOM   1444 C  C   . MET A 1 204 ? -10.175 -48.603 -19.488 1.00 40.58  ?  204 MET A C   1 
ATOM   1445 O  O   . MET A 1 204 ? -10.927 -49.576 -19.357 1.00 38.97  ?  204 MET A O   1 
ATOM   1446 C  CB  . MET A 1 204 ? -10.766 -46.429 -18.358 1.00 38.71  ?  204 MET A CB  1 
ATOM   1447 C  CG  . MET A 1 204 ? -10.743 -45.518 -17.110 1.00 35.42  ?  204 MET A CG  1 
ATOM   1448 S  SD  . MET A 1 204 ? -11.271 -46.245 -15.553 1.00 37.71  ?  204 MET A SD  1 
ATOM   1449 C  CE  . MET A 1 204 ? -13.024 -46.527 -15.883 1.00 42.11  ?  204 MET A CE  1 
ATOM   1450 N  N   . VAL A 1 205 ? -9.587  -48.314 -20.653 1.00 40.91  ?  205 VAL A N   1 
ATOM   1451 C  CA  . VAL A 1 205 ? -9.703  -49.221 -21.799 1.00 41.62  ?  205 VAL A CA  1 
ATOM   1452 C  C   . VAL A 1 205 ? -9.239  -50.621 -21.415 1.00 43.62  ?  205 VAL A C   1 
ATOM   1453 O  O   . VAL A 1 205 ? -9.940  -51.615 -21.649 1.00 44.56  ?  205 VAL A O   1 
ATOM   1454 C  CB  . VAL A 1 205 ? -8.902  -48.689 -23.002 1.00 40.00  ?  205 VAL A CB  1 
ATOM   1455 C  CG1 . VAL A 1 205 ? -8.790  -49.774 -24.075 1.00 45.89  ?  205 VAL A CG1 1 
ATOM   1456 C  CG2 . VAL A 1 205 ? -9.537  -47.440 -23.577 1.00 40.22  ?  205 VAL A CG2 1 
ATOM   1457 N  N   . ASP A 1 206 ? -8.047  -50.709 -20.813 1.00 39.47  ?  206 ASP A N   1 
ATOM   1458 C  CA  . ASP A 1 206 ? -7.487  -51.985 -20.376 1.00 42.83  ?  206 ASP A CA  1 
ATOM   1459 C  C   . ASP A 1 206 ? -8.446  -52.746 -19.468 1.00 46.00  ?  206 ASP A C   1 
ATOM   1460 O  O   . ASP A 1 206 ? -8.556  -53.973 -19.567 1.00 44.09  ?  206 ASP A O   1 
ATOM   1461 C  CB  . ASP A 1 206 ? -6.162  -51.755 -19.644 1.00 43.97  ?  206 ASP A CB  1 
ATOM   1462 C  CG  . ASP A 1 206 ? -5.026  -51.329 -20.569 1.00 48.40  ?  206 ASP A CG  1 
ATOM   1463 O  OD1 . ASP A 1 206 ? -5.237  -51.234 -21.797 1.00 51.15  ?  206 ASP A OD1 1 
ATOM   1464 O  OD2 . ASP A 1 206 ? -3.924  -51.037 -20.047 1.00 49.91  ?  206 ASP A OD2 1 
ATOM   1465 N  N   . ARG A 1 207 ? -9.120  -52.043 -18.548 1.00 43.49  ?  207 ARG A N   1 
ATOM   1466 C  CA  . ARG A 1 207 ? -10.062 -52.721 -17.659 1.00 42.25  ?  207 ARG A CA  1 
ATOM   1467 C  C   . ARG A 1 207 ? -11.297 -53.185 -18.423 1.00 46.83  ?  207 ARG A C   1 
ATOM   1468 O  O   . ARG A 1 207 ? -11.807 -54.288 -18.186 1.00 46.38  ?  207 ARG A O   1 
ATOM   1469 C  CB  . ARG A 1 207 ? -10.475 -51.803 -16.501 1.00 44.04  ?  207 ARG A CB  1 
ATOM   1470 C  CG  . ARG A 1 207 ? -9.319  -51.138 -15.741 1.00 45.07  ?  207 ARG A CG  1 
ATOM   1471 C  CD  . ARG A 1 207 ? -8.788  -52.000 -14.601 1.00 43.41  ?  207 ARG A CD  1 
ATOM   1472 N  NE  . ARG A 1 207 ? -7.811  -52.981 -15.056 1.00 49.26  ?  207 ARG A NE  1 
ATOM   1473 C  CZ  . ARG A 1 207 ? -6.638  -52.695 -15.615 1.00 52.14  ?  207 ARG A CZ  1 
ATOM   1474 N  NH1 . ARG A 1 207 ? -6.227  -51.443 -15.783 1.00 44.41  ?  207 ARG A NH1 1 
ATOM   1475 N  NH2 . ARG A 1 207 ? -5.845  -53.693 -16.004 1.00 52.09  ?  207 ARG A NH2 1 
ATOM   1476 N  N   . LEU A 1 208 ? -11.799 -52.350 -19.335 1.00 44.22  ?  208 LEU A N   1 
ATOM   1477 C  CA  . LEU A 1 208 ? -12.971 -52.722 -20.120 1.00 44.99  ?  208 LEU A CA  1 
ATOM   1478 C  C   . LEU A 1 208 ? -12.675 -53.909 -21.031 1.00 49.33  ?  208 LEU A C   1 
ATOM   1479 O  O   . LEU A 1 208 ? -13.549 -54.753 -21.264 1.00 49.26  ?  208 LEU A O   1 
ATOM   1480 C  CB  . LEU A 1 208 ? -13.441 -51.530 -20.947 1.00 43.75  ?  208 LEU A CB  1 
ATOM   1481 C  CG  . LEU A 1 208 ? -14.601 -51.791 -21.909 1.00 51.51  ?  208 LEU A CG  1 
ATOM   1482 C  CD1 . LEU A 1 208 ? -15.891 -52.067 -21.135 1.00 47.47  ?  208 LEU A CD1 1 
ATOM   1483 C  CD2 . LEU A 1 208 ? -14.779 -50.626 -22.864 1.00 47.52  ?  208 LEU A CD2 1 
ATOM   1484 N  N   . ASN A 1 209 ? -11.449 -53.993 -21.547 1.00 45.75  ?  209 ASN A N   1 
ATOM   1485 C  CA  . ASN A 1 209 ? -11.077 -54.993 -22.535 1.00 49.16  ?  209 ASN A CA  1 
ATOM   1486 C  C   . ASN A 1 209 ? -10.257 -56.134 -21.937 1.00 52.47  ?  209 ASN A C   1 
ATOM   1487 O  O   . ASN A 1 209 ? -9.521  -56.807 -22.667 1.00 55.98  ?  209 ASN A O   1 
ATOM   1488 C  CB  . ASN A 1 209 ? -10.318 -54.327 -23.686 1.00 47.36  ?  209 ASN A CB  1 
ATOM   1489 C  CG  . ASN A 1 209 ? -11.226 -53.515 -24.589 1.00 48.01  ?  209 ASN A CG  1 
ATOM   1490 O  OD1 . ASN A 1 209 ? -12.433 -53.744 -24.636 1.00 51.23  ?  209 ASN A OD1 1 
ATOM   1491 N  ND2 . ASN A 1 209 ? -10.652 -52.559 -25.314 1.00 47.05  ?  209 ASN A ND2 1 
ATOM   1492 N  N   . ALA A 1 210 ? -10.427 -56.371 -20.646 1.00 51.01  ?  210 ALA A N   1 
ATOM   1493 C  CA  . ALA A 1 210 ? -9.729  -57.507 -20.020 1.00 54.99  ?  210 ALA A CA  1 
ATOM   1494 C  C   . ALA A 1 210 ? -10.310 -58.808 -20.573 1.00 65.09  ?  210 ALA A C   1 
ATOM   1495 O  O   . ALA A 1 210 ? -11.513 -58.849 -20.876 1.00 60.04  ?  210 ALA A O   1 
ATOM   1496 C  CB  . ALA A 1 210 ? -9.877  -57.421 -18.532 1.00 56.91  ?  210 ALA A CB  1 
ATOM   1497 N  N   . ASP A 1 211 ? -9.465  -59.827 -20.719 1.00 71.43  ?  211 ASP A N   1 
ATOM   1498 C  CA  . ASP A 1 211 ? -9.920  -61.131 -21.279 1.00 74.40  ?  211 ASP A CA  1 
ATOM   1499 C  C   . ASP A 1 211 ? -11.020 -61.641 -20.357 1.00 77.12  ?  211 ASP A C   1 
ATOM   1500 O  O   . ASP A 1 211 ? -12.143 -61.843 -20.855 1.00 81.17  ?  211 ASP A O   1 
ATOM   1501 C  CB  . ASP A 1 211 ? -8.769  -62.087 -21.554 1.00 81.40  ?  211 ASP A CB  1 
ATOM   1502 N  N   . PRO A 1 212 ? -10.783 -61.876 -19.051 1.00 73.99  ?  212 PRO A N   1 
ATOM   1503 C  CA  . PRO A 1 212 ? -11.898 -62.191 -18.184 1.00 73.35  ?  212 PRO A CA  1 
ATOM   1504 C  C   . PRO A 1 212 ? -12.747 -60.918 -18.187 1.00 70.41  ?  212 PRO A C   1 
ATOM   1505 O  O   . PRO A 1 212 ? -12.641 -60.119 -17.248 1.00 68.90  ?  212 PRO A O   1 
ATOM   1506 C  CB  . PRO A 1 212 ? -11.287 -62.502 -16.828 1.00 71.56  ?  212 PRO A CB  1 
ATOM   1507 C  CG  . PRO A 1 212 ? -9.875  -61.964 -16.908 1.00 75.97  ?  212 PRO A CG  1 
ATOM   1508 C  CD  . PRO A 1 212 ? -9.498  -61.893 -18.375 1.00 74.46  ?  212 PRO A CD  1 
ATOM   1509 N  N   . GLU A 1 213 ? -13.544 -60.704 -19.238 1.00 66.82  ?  213 GLU A N   1 
ATOM   1510 C  CA  . GLU A 1 213 ? -14.349 -59.462 -19.369 1.00 63.56  ?  213 GLU A CA  1 
ATOM   1511 C  C   . GLU A 1 213 ? -14.983 -58.997 -18.056 1.00 61.75  ?  213 GLU A C   1 
ATOM   1512 O  O   . GLU A 1 213 ? -15.424 -59.849 -17.267 1.00 57.73  ?  213 GLU A O   1 
ATOM   1513 C  CB  . GLU A 1 213 ? -15.471 -59.601 -20.392 1.00 63.99  ?  213 GLU A CB  1 
ATOM   1514 C  CG  . GLU A 1 213 ? -14.972 -59.755 -21.823 1.00 64.86  ?  213 GLU A CG  1 
ATOM   1515 C  CD  . GLU A 1 213 ? -16.079 -59.965 -22.834 1.00 72.56  ?  213 GLU A CD  1 
ATOM   1516 O  OE1 . GLU A 1 213 ? -17.237 -60.184 -22.421 1.00 71.85  ?  213 GLU A OE1 1 
ATOM   1517 O  OE2 . GLU A 1 213 ? -15.771 -59.905 -24.041 1.00 68.74  ?  213 GLU A OE2 1 
ATOM   1518 N  N   . PRO A 1 214 ? -15.052 -57.675 -17.797 1.00 60.34  ?  214 PRO A N   1 
ATOM   1519 C  CA  . PRO A 1 214 ? -15.656 -57.168 -16.563 1.00 54.60  ?  214 PRO A CA  1 
ATOM   1520 C  C   . PRO A 1 214 ? -17.131 -57.520 -16.486 1.00 52.87  ?  214 PRO A C   1 
ATOM   1521 O  O   . PRO A 1 214 ? -17.901 -57.295 -17.423 1.00 50.58  ?  214 PRO A O   1 
ATOM   1522 C  CB  . PRO A 1 214 ? -15.446 -55.652 -16.661 1.00 51.99  ?  214 PRO A CB  1 
ATOM   1523 C  CG  . PRO A 1 214 ? -15.279 -55.396 -18.123 1.00 50.82  ?  214 PRO A CG  1 
ATOM   1524 C  CD  . PRO A 1 214 ? -14.500 -56.576 -18.608 1.00 56.22  ?  214 PRO A CD  1 
ATOM   1525 N  N   . THR A 1 215 ? -17.508 -58.107 -15.370 1.00 53.88  ?  215 THR A N   1 
ATOM   1526 C  CA  . THR A 1 215 ? -18.861 -58.013 -14.863 1.00 57.73  ?  215 THR A CA  1 
ATOM   1527 C  C   . THR A 1 215 ? -18.860 -56.971 -13.747 1.00 62.63  ?  215 THR A C   1 
ATOM   1528 O  O   . THR A 1 215 ? -17.809 -56.451 -13.358 1.00 69.45  ?  215 THR A O   1 
ATOM   1529 C  CB  . THR A 1 215 ? -19.343 -59.379 -14.374 1.00 60.59  ?  215 THR A CB  1 
ATOM   1530 O  OG1 . THR A 1 215 ? -18.753 -59.668 -13.105 1.00 63.29  ?  215 THR A OG1 1 
ATOM   1531 C  CG2 . THR A 1 215 ? -18.923 -60.458 -15.362 1.00 59.68  ?  215 THR A CG2 1 
ATOM   1532 N  N   . GLU A 1 216 ? -20.050 -56.648 -13.251 1.00 63.44  ?  216 GLU A N   1 
ATOM   1533 C  CA  . GLU A 1 216 ? -20.223 -55.700 -12.150 1.00 59.12  ?  216 GLU A CA  1 
ATOM   1534 C  C   . GLU A 1 216 ? -19.933 -54.252 -12.543 1.00 54.99  ?  216 GLU A C   1 
ATOM   1535 O  O   . GLU A 1 216 ? -18.953 -53.951 -13.237 1.00 48.09  ?  216 GLU A O   1 
ATOM   1536 C  CB  . GLU A 1 216 ? -19.361 -56.082 -10.935 1.00 59.57  ?  216 GLU A CB  1 
ATOM   1537 C  CG  . GLU A 1 216 ? -19.422 -57.554 -10.523 1.00 65.75  ?  216 GLU A CG  1 
ATOM   1538 C  CD  . GLU A 1 216 ? -20.750 -57.930 -9.882  1.00 73.85  ?  216 GLU A CD  1 
ATOM   1539 O  OE1 . GLU A 1 216 ? -21.576 -57.022 -9.634  1.00 73.38  ?  216 GLU A OE1 1 
ATOM   1540 O  OE2 . GLU A 1 216 ? -20.969 -59.140 -9.630  1.00 78.29  ?  216 GLU A OE2 1 
ATOM   1541 N  N   . GLY A 1 217 ? -20.804 -53.352 -12.095 1.00 52.25  ?  217 GLY A N   1 
ATOM   1542 C  CA  . GLY A 1 217 ? -20.603 -51.929 -12.236 1.00 48.33  ?  217 GLY A CA  1 
ATOM   1543 C  C   . GLY A 1 217 ? -20.748 -51.420 -13.661 1.00 47.82  ?  217 GLY A C   1 
ATOM   1544 O  O   . GLY A 1 217 ? -21.276 -52.079 -14.561 1.00 45.09  ?  217 GLY A O   1 
ATOM   1545 N  N   . LEU A 1 218 ? -20.243 -50.197 -13.842 1.00 39.83  ?  218 LEU A N   1 
ATOM   1546 C  CA  . LEU A 1 218 ? -20.382 -49.495 -15.109 1.00 44.86  ?  218 LEU A CA  1 
ATOM   1547 C  C   . LEU A 1 218 ? -19.648 -50.214 -16.232 1.00 43.79  ?  218 LEU A C   1 
ATOM   1548 O  O   . LEU A 1 218 ? -20.138 -50.269 -17.366 1.00 45.94  ?  218 LEU A O   1 
ATOM   1549 C  CB  . LEU A 1 218 ? -19.866 -48.063 -14.971 1.00 41.17  ?  218 LEU A CB  1 
ATOM   1550 C  CG  . LEU A 1 218 ? -20.128 -47.173 -16.186 1.00 46.30  ?  218 LEU A CG  1 
ATOM   1551 C  CD1 . LEU A 1 218 ? -21.579 -46.719 -16.225 1.00 48.65  ?  218 LEU A CD1 1 
ATOM   1552 C  CD2 . LEU A 1 218 ? -19.179 -45.983 -16.244 1.00 40.15  ?  218 LEU A CD2 1 
ATOM   1553 N  N   . LEU A 1 219 ? -18.466 -50.758 -15.949 1.00 38.50  ?  219 LEU A N   1 
ATOM   1554 C  CA  . LEU A 1 219 ? -17.733 -51.434 -17.010 1.00 43.07  ?  219 LEU A CA  1 
ATOM   1555 C  C   . LEU A 1 219 ? -18.404 -52.753 -17.364 1.00 47.67  ?  219 LEU A C   1 
ATOM   1556 O  O   . LEU A 1 219 ? -18.360 -53.174 -18.525 1.00 47.55  ?  219 LEU A O   1 
ATOM   1557 C  CB  . LEU A 1 219 ? -16.273 -51.662 -16.612 1.00 39.69  ?  219 LEU A CB  1 
ATOM   1558 C  CG  . LEU A 1 219 ? -15.359 -50.428 -16.540 1.00 39.88  ?  219 LEU A CG  1 
ATOM   1559 C  CD1 . LEU A 1 219 ? -13.904 -50.840 -16.630 1.00 41.41  ?  219 LEU A CD1 1 
ATOM   1560 C  CD2 . LEU A 1 219 ? -15.691 -49.400 -17.616 1.00 40.02  ?  219 LEU A CD2 1 
ATOM   1561 N  N   . GLY A 1 220 ? -19.045 -53.398 -16.387 1.00 46.59  ?  220 GLY A N   1 
ATOM   1562 C  CA  . GLY A 1 220 ? -19.816 -54.595 -16.688 1.00 52.00  ?  220 GLY A CA  1 
ATOM   1563 C  C   . GLY A 1 220 ? -21.002 -54.287 -17.579 1.00 48.90  ?  220 GLY A C   1 
ATOM   1564 O  O   . GLY A 1 220 ? -21.262 -54.990 -18.559 1.00 50.65  ?  220 GLY A O   1 
ATOM   1565 N  N   . ARG A 1 221 ? -21.728 -53.213 -17.259 1.00 45.71  ?  221 ARG A N   1 
ATOM   1566 C  CA  . ARG A 1 221 ? -22.829 -52.788 -18.117 1.00 49.39  ?  221 ARG A CA  1 
ATOM   1567 C  C   . ARG A 1 221 ? -22.336 -52.355 -19.492 1.00 53.78  ?  221 ARG A C   1 
ATOM   1568 O  O   . ARG A 1 221 ? -23.005 -52.617 -20.501 1.00 54.71  ?  221 ARG A O   1 
ATOM   1569 C  CB  . ARG A 1 221 ? -23.618 -51.665 -17.446 1.00 48.64  ?  221 ARG A CB  1 
ATOM   1570 C  CG  . ARG A 1 221 ? -24.160 -52.061 -16.087 1.00 48.69  ?  221 ARG A CG  1 
ATOM   1571 C  CD  . ARG A 1 221 ? -25.003 -50.955 -15.464 1.00 54.16  ?  221 ARG A CD  1 
ATOM   1572 N  NE  . ARG A 1 221 ? -25.643 -51.410 -14.232 1.00 56.15  ?  221 ARG A NE  1 
ATOM   1573 C  CZ  . ARG A 1 221 ? -25.190 -51.151 -13.013 1.00 56.25  ?  221 ARG A CZ  1 
ATOM   1574 N  NH1 . ARG A 1 221 ? -24.121 -50.393 -12.818 1.00 55.34  ?  221 ARG A NH1 1 
ATOM   1575 N  NH2 . ARG A 1 221 ? -25.825 -51.662 -11.963 1.00 60.00  ?  221 ARG A NH2 1 
ATOM   1576 N  N   . PHE A 1 222 ? -21.168 -51.709 -19.558 1.00 48.06  ?  222 PHE A N   1 
ATOM   1577 C  CA  . PHE A 1 222 ? -20.612 -51.309 -20.849 1.00 49.24  ?  222 PHE A CA  1 
ATOM   1578 C  C   . PHE A 1 222 ? -20.271 -52.524 -21.707 1.00 52.05  ?  222 PHE A C   1 
ATOM   1579 O  O   . PHE A 1 222 ? -20.548 -52.536 -22.913 1.00 53.26  ?  222 PHE A O   1 
ATOM   1580 C  CB  . PHE A 1 222 ? -19.369 -50.443 -20.639 1.00 47.93  ?  222 PHE A CB  1 
ATOM   1581 C  CG  . PHE A 1 222 ? -19.670 -49.009 -20.317 1.00 43.23  ?  222 PHE A CG  1 
ATOM   1582 C  CD1 . PHE A 1 222 ? -20.976 -48.565 -20.206 1.00 44.67  ?  222 PHE A CD1 1 
ATOM   1583 C  CD2 . PHE A 1 222 ? -18.635 -48.100 -20.108 1.00 44.71  ?  222 PHE A CD2 1 
ATOM   1584 C  CE1 . PHE A 1 222 ? -21.256 -47.239 -19.904 1.00 47.35  ?  222 PHE A CE1 1 
ATOM   1585 C  CE2 . PHE A 1 222 ? -18.907 -46.781 -19.808 1.00 44.16  ?  222 PHE A CE2 1 
ATOM   1586 C  CZ  . PHE A 1 222 ? -20.218 -46.347 -19.702 1.00 45.98  ?  222 PHE A CZ  1 
ATOM   1587 N  N   . ALA A 1 223 ? -19.659 -53.545 -21.101 1.00 52.14  ?  223 ALA A N   1 
ATOM   1588 C  CA  . ALA A 1 223 ? -19.315 -54.770 -21.820 1.00 57.00  ?  223 ALA A CA  1 
ATOM   1589 C  C   . ALA A 1 223 ? -20.553 -55.432 -22.411 1.00 62.02  ?  223 ALA A C   1 
ATOM   1590 O  O   . ALA A 1 223 ? -20.543 -55.883 -23.563 1.00 64.06  ?  223 ALA A O   1 
ATOM   1591 C  CB  . ALA A 1 223 ? -18.594 -55.738 -20.883 1.00 55.88  ?  223 ALA A CB  1 
ATOM   1592 N  N   . GLU A 1 224 ? -21.627 -55.514 -21.623 1.00 58.18  ?  224 GLU A N   1 
ATOM   1593 C  CA  . GLU A 1 224 ? -22.877 -56.073 -22.128 1.00 66.08  ?  224 GLU A CA  1 
ATOM   1594 C  C   . GLU A 1 224 ? -23.433 -55.225 -23.259 1.00 66.77  ?  224 GLU A C   1 
ATOM   1595 O  O   . GLU A 1 224 ? -23.944 -55.754 -24.253 1.00 69.67  ?  224 GLU A O   1 
ATOM   1596 C  CB  . GLU A 1 224 ? -23.895 -56.178 -20.995 1.00 65.54  ?  224 GLU A CB  1 
ATOM   1597 N  N   . LEU A 1 225 ? -23.311 -53.904 -23.136 1.00 62.60  ?  225 LEU A N   1 
ATOM   1598 C  CA  . LEU A 1 225 ? -23.960 -52.999 -24.074 1.00 64.11  ?  225 LEU A CA  1 
ATOM   1599 C  C   . LEU A 1 225 ? -23.379 -53.122 -25.477 1.00 68.88  ?  225 LEU A C   1 
ATOM   1600 O  O   . LEU A 1 225 ? -24.119 -53.050 -26.464 1.00 74.64  ?  225 LEU A O   1 
ATOM   1601 C  CB  . LEU A 1 225 ? -23.842 -51.564 -23.571 1.00 63.90  ?  225 LEU A CB  1 
ATOM   1602 C  CG  . LEU A 1 225 ? -24.652 -50.539 -24.359 1.00 67.29  ?  225 LEU A CG  1 
ATOM   1603 C  CD1 . LEU A 1 225 ? -26.142 -50.710 -24.089 1.00 69.79  ?  225 LEU A CD1 1 
ATOM   1604 C  CD2 . LEU A 1 225 ? -24.207 -49.157 -23.992 1.00 64.37  ?  225 LEU A CD2 1 
ATOM   1605 N  N   . ARG A 1 226 ? -22.078 -53.439 -25.518 1.00 66.22  ?  226 ARG A N   1 
ATOM   1606 C  CA  . ARG A 1 226 ? -21.347 -53.584 -26.800 1.00 70.00  ?  226 ARG A CA  1 
ATOM   1607 C  C   . ARG A 1 226 ? -21.788 -54.851 -27.541 1.00 73.95  ?  226 ARG A C   1 
ATOM   1608 O  O   . ARG A 1 226 ? -21.924 -54.791 -28.770 1.00 76.73  ?  226 ARG A O   1 
ATOM   1609 C  CB  . ARG A 1 226 ? -19.848 -53.736 -26.538 1.00 63.88  ?  226 ARG A CB  1 
ATOM   1610 C  CG  . ARG A 1 226 ? -19.109 -52.557 -25.925 1.00 63.64  ?  226 ARG A CG  1 
ATOM   1611 C  CD  . ARG A 1 226 ? -17.605 -52.722 -26.069 1.00 57.57  ?  226 ARG A CD  1 
ATOM   1612 N  NE  . ARG A 1 226 ? -17.057 -53.795 -25.234 1.00 55.56  ?  226 ARG A NE  1 
ATOM   1613 C  CZ  . ARG A 1 226 ? -15.767 -53.947 -24.974 1.00 54.53  ?  226 ARG A CZ  1 
ATOM   1614 N  NH1 . ARG A 1 226 ? -14.893 -53.088 -25.462 1.00 56.11  ?  226 ARG A NH1 1 
ATOM   1615 N  NH2 . ARG A 1 226 ? -15.352 -54.954 -24.230 1.00 52.01  ?  226 ARG A NH2 1 
ATOM   1616 N  N   . ARG A 1 227 ? -21.982 -55.950 -26.818 1.00 73.51  ?  227 ARG A N   1 
ATOM   1617 C  CA  . ARG A 1 227 ? -22.377 -57.233 -27.450 1.00 75.72  ?  227 ARG A CA  1 
ATOM   1618 C  C   . ARG A 1 227 ? -23.833 -57.147 -27.923 1.00 83.98  ?  227 ARG A C   1 
ATOM   1619 O  O   . ARG A 1 227 ? -24.249 -58.017 -28.707 1.00 88.69  ?  227 ARG A O   1 
ATOM   1620 C  CB  . ARG A 1 227 ? -22.191 -58.391 -26.470 1.00 71.66  ?  227 ARG A CB  1 
ATOM   1621 C  CG  . ARG A 1 227 ? -20.754 -58.513 -25.986 1.00 72.42  ?  227 ARG A CG  1 
ATOM   1622 C  CD  . ARG A 1 227 ? -20.573 -59.701 -25.061 1.00 71.56  ?  227 ARG A CD  1 
ATOM   1623 N  NE  . ARG A 1 227 ? -20.212 -59.281 -23.704 1.00 72.25  ?  227 ARG A NE  1 
ATOM   1624 C  CZ  . ARG A 1 227 ? -21.056 -59.255 -22.684 1.00 75.19  ?  227 ARG A CZ  1 
ATOM   1625 N  NH1 . ARG A 1 227 ? -22.317 -59.603 -22.861 1.00 73.36  ?  227 ARG A NH1 1 
ATOM   1626 N  NH2 . ARG A 1 227 ? -20.633 -58.884 -21.489 1.00 73.78  ?  227 ARG A NH2 1 
ATOM   1627 N  N   . SER A 1 228 ? -24.567 -56.133 -27.474 1.00 83.33  ?  228 SER A N   1 
ATOM   1628 C  CA  . SER A 1 228 ? -25.992 -55.990 -27.854 1.00 91.52  ?  228 SER A CA  1 
ATOM   1629 C  C   . SER A 1 228 ? -26.100 -55.452 -29.279 1.00 100.03 ?  228 SER A C   1 
ATOM   1630 O  O   . SER A 1 228 ? -25.106 -54.902 -29.775 1.00 99.68  ?  228 SER A O   1 
ATOM   1631 C  CB  . SER A 1 228 ? -26.700 -55.077 -26.903 1.00 93.19  ?  228 SER A CB  1 
ATOM   1632 O  OG  . SER A 1 228 ? -26.163 -53.765 -26.978 1.00 101.98 ?  228 SER A OG  1 
ATOM   1633 N  N   . PRO A 1 229 ? -27.248 -55.612 -29.967 1.00 106.24 ?  229 PRO A N   1 
ATOM   1634 C  CA  . PRO A 1 229 ? -27.435 -55.013 -31.280 1.00 108.44 ?  229 PRO A CA  1 
ATOM   1635 C  C   . PRO A 1 229 ? -28.338 -53.790 -31.238 1.00 110.56 ?  229 PRO A C   1 
ATOM   1636 O  O   . PRO A 1 229 ? -28.078 -52.892 -32.059 1.00 112.01 ?  229 PRO A O   1 
ATOM   1637 C  CB  . PRO A 1 229 ? -28.090 -56.199 -31.973 1.00 109.00 ?  229 PRO A CB  1 
ATOM   1638 C  CG  . PRO A 1 229 ? -29.005 -56.779 -30.914 1.00 107.21 ?  229 PRO A CG  1 
ATOM   1639 C  CD  . PRO A 1 229 ? -28.361 -56.455 -29.576 1.00 104.05 ?  229 PRO A CD  1 
ATOM   1640 N  N   . VAL A 1 235 ? -21.110 -46.247 -30.615 1.00 99.06  ?  235 VAL A N   1 
ATOM   1641 C  CA  . VAL A 1 235 ? -20.348 -45.934 -29.406 1.00 83.05  ?  235 VAL A CA  1 
ATOM   1642 C  C   . VAL A 1 235 ? -19.082 -46.785 -29.417 1.00 77.25  ?  235 VAL A C   1 
ATOM   1643 O  O   . VAL A 1 235 ? -19.139 -47.991 -29.672 1.00 81.00  ?  235 VAL A O   1 
ATOM   1644 C  CB  . VAL A 1 235 ? -21.158 -46.150 -28.111 1.00 82.05  ?  235 VAL A CB  1 
ATOM   1645 C  CG1 . VAL A 1 235 ? -21.786 -47.532 -28.093 1.00 88.39  ?  235 VAL A CG1 1 
ATOM   1646 C  CG2 . VAL A 1 235 ? -20.250 -45.975 -26.910 1.00 73.88  ?  235 VAL A CG2 1 
ATOM   1647 N  N   . SER A 1 236 ? -17.931 -46.153 -29.163 1.00 65.47  ?  236 SER A N   1 
ATOM   1648 C  CA  . SER A 1 236 ? -16.622 -46.781 -29.316 1.00 57.67  ?  236 SER A CA  1 
ATOM   1649 C  C   . SER A 1 236 ? -15.989 -47.073 -27.955 1.00 56.16  ?  236 SER A C   1 
ATOM   1650 O  O   . SER A 1 236 ? -16.482 -46.661 -26.898 1.00 54.40  ?  236 SER A O   1 
ATOM   1651 C  CB  . SER A 1 236 ? -15.698 -45.885 -30.133 1.00 57.15  ?  236 SER A CB  1 
ATOM   1652 O  OG  . SER A 1 236 ? -15.484 -44.656 -29.452 1.00 56.51  ?  236 SER A OG  1 
ATOM   1653 N  N   . ASP A 1 237 ? -14.860 -47.781 -27.997 1.00 50.99  ?  237 ASP A N   1 
ATOM   1654 C  CA  . ASP A 1 237 ? -14.109 -48.059 -26.778 1.00 51.84  ?  237 ASP A CA  1 
ATOM   1655 C  C   . ASP A 1 237 ? -13.596 -46.771 -26.136 1.00 51.92  ?  237 ASP A C   1 
ATOM   1656 O  O   . ASP A 1 237 ? -13.612 -46.638 -24.905 1.00 48.75  ?  237 ASP A O   1 
ATOM   1657 C  CB  . ASP A 1 237 ? -12.949 -49.005 -27.084 1.00 51.93  ?  237 ASP A CB  1 
ATOM   1658 C  CG  . ASP A 1 237 ? -13.369 -50.473 -27.095 1.00 55.52  ?  237 ASP A CG  1 
ATOM   1659 O  OD1 . ASP A 1 237 ? -14.593 -50.761 -27.087 1.00 54.84  ?  237 ASP A OD1 1 
ATOM   1660 O  OD2 . ASP A 1 237 ? -12.465 -51.339 -27.115 1.00 57.42  ?  237 ASP A OD2 1 
ATOM   1661 N  N   . GLU A 1 238 ? -13.149 -45.810 -26.950 1.00 48.08  ?  238 GLU A N   1 
ATOM   1662 C  CA  . GLU A 1 238 ? -12.680 -44.539 -26.404 1.00 52.92  ?  238 GLU A CA  1 
ATOM   1663 C  C   . GLU A 1 238 ? -13.797 -43.797 -25.681 1.00 50.90  ?  238 GLU A C   1 
ATOM   1664 O  O   . GLU A 1 238 ? -13.572 -43.222 -24.608 1.00 46.96  ?  238 GLU A O   1 
ATOM   1665 C  CB  . GLU A 1 238 ? -12.084 -43.657 -27.503 1.00 55.64  ?  238 GLU A CB  1 
ATOM   1666 C  CG  . GLU A 1 238 ? -11.801 -42.229 -27.013 1.00 60.34  ?  238 GLU A CG  1 
ATOM   1667 C  CD  . GLU A 1 238 ? -10.965 -41.385 -27.968 1.00 69.94  ?  238 GLU A CD  1 
ATOM   1668 O  OE1 . GLU A 1 238 ? -11.558 -40.718 -28.847 1.00 74.00  ?  238 GLU A OE1 1 
ATOM   1669 O  OE2 . GLU A 1 238 ? -9.717  -41.362 -27.812 1.00 65.85  ?  238 GLU A OE2 1 
ATOM   1670 N  N   . LEU A 1 239 ? -15.011 -43.800 -26.241 1.00 47.35  ?  239 LEU A N   1 
ATOM   1671 C  CA  . LEU A 1 239 ? -16.103 -43.090 -25.582 1.00 45.18  ?  239 LEU A CA  1 
ATOM   1672 C  C   . LEU A 1 239 ? -16.480 -43.767 -24.274 1.00 46.08  ?  239 LEU A C   1 
ATOM   1673 O  O   . LEU A 1 239 ? -16.715 -43.090 -23.264 1.00 45.99  ?  239 LEU A O   1 
ATOM   1674 C  CB  . LEU A 1 239 ? -17.324 -43.000 -26.497 1.00 55.49  ?  239 LEU A CB  1 
ATOM   1675 C  CG  . LEU A 1 239 ? -18.539 -42.241 -25.937 1.00 51.73  ?  239 LEU A CG  1 
ATOM   1676 C  CD1 . LEU A 1 239 ? -18.140 -40.965 -25.182 1.00 53.13  ?  239 LEU A CD1 1 
ATOM   1677 C  CD2 . LEU A 1 239 ? -19.545 -41.918 -27.042 1.00 62.87  ?  239 LEU A CD2 1 
ATOM   1678 N  N   . LEU A 1 240 ? -16.553 -45.100 -24.271 1.00 46.68  ?  240 LEU A N   1 
ATOM   1679 C  CA  . LEU A 1 240 ? -16.908 -45.817 -23.051 1.00 44.93  ?  240 LEU A CA  1 
ATOM   1680 C  C   . LEU A 1 240 ? -15.912 -45.516 -21.932 1.00 44.72  ?  240 LEU A C   1 
ATOM   1681 O  O   . LEU A 1 240 ? -16.308 -45.203 -20.804 1.00 41.42  ?  240 LEU A O   1 
ATOM   1682 C  CB  . LEU A 1 240 ? -16.976 -47.322 -23.326 1.00 44.91  ?  240 LEU A CB  1 
ATOM   1683 C  CG  . LEU A 1 240 ? -18.156 -47.818 -24.171 1.00 45.18  ?  240 LEU A CG  1 
ATOM   1684 C  CD1 . LEU A 1 240 ? -18.126 -49.340 -24.295 1.00 47.92  ?  240 LEU A CD1 1 
ATOM   1685 C  CD2 . LEU A 1 240 ? -19.473 -47.342 -23.576 1.00 46.13  ?  240 LEU A CD2 1 
ATOM   1686 N  N   . ALA A 1 241 ? -14.611 -45.619 -22.227 1.00 37.11  ?  241 ALA A N   1 
ATOM   1687 C  CA  . ALA A 1 241 ? -13.593 -45.351 -21.213 1.00 40.20  ?  241 ALA A CA  1 
ATOM   1688 C  C   . ALA A 1 241 ? -13.586 -43.885 -20.792 1.00 38.33  ?  241 ALA A C   1 
ATOM   1689 O  O   . ALA A 1 241 ? -13.281 -43.576 -19.631 1.00 38.68  ?  241 ALA A O   1 
ATOM   1690 C  CB  . ALA A 1 241 ? -12.210 -45.761 -21.727 1.00 39.90  ?  241 ALA A CB  1 
ATOM   1691 N  N   . THR A 1 242 ? -13.896 -42.975 -21.718 1.00 38.36  ?  242 THR A N   1 
ATOM   1692 C  CA  . THR A 1 242 ? -14.004 -41.562 -21.368 1.00 41.32  ?  242 THR A CA  1 
ATOM   1693 C  C   . THR A 1 242 ? -15.088 -41.341 -20.319 1.00 43.30  ?  242 THR A C   1 
ATOM   1694 O  O   . THR A 1 242 ? -14.902 -40.579 -19.362 1.00 38.32  ?  242 THR A O   1 
ATOM   1695 C  CB  . THR A 1 242 ? -14.298 -40.727 -22.619 1.00 42.31  ?  242 THR A CB  1 
ATOM   1696 O  OG1 . THR A 1 242 ? -13.140 -40.681 -23.451 1.00 42.00  ?  242 THR A OG1 1 
ATOM   1697 C  CG2 . THR A 1 242 ? -14.675 -39.295 -22.229 1.00 38.86  ?  242 THR A CG2 1 
ATOM   1698 N  N   . VAL A 1 243 ? -16.246 -41.976 -20.500 1.00 40.09  ?  243 VAL A N   1 
ATOM   1699 C  CA  . VAL A 1 243 ? -17.318 -41.843 -19.517 1.00 39.42  ?  243 VAL A CA  1 
ATOM   1700 C  C   . VAL A 1 243 ? -16.879 -42.425 -18.180 1.00 38.90  ?  243 VAL A C   1 
ATOM   1701 O  O   . VAL A 1 243 ? -17.070 -41.813 -17.119 1.00 39.84  ?  243 VAL A O   1 
ATOM   1702 C  CB  . VAL A 1 243 ? -18.602 -42.522 -20.037 1.00 42.98  ?  243 VAL A CB  1 
ATOM   1703 C  CG1 . VAL A 1 243 ? -19.682 -42.527 -18.965 1.00 41.24  ?  243 VAL A CG1 1 
ATOM   1704 C  CG2 . VAL A 1 243 ? -19.110 -41.819 -21.277 1.00 40.36  ?  243 VAL A CG2 1 
ATOM   1705 N  N   . ALA A 1 244 ? -16.276 -43.613 -18.211 1.00 30.78  ?  244 ALA A N   1 
ATOM   1706 C  CA  . ALA A 1 244 ? -15.755 -44.218 -16.993 1.00 36.79  ?  244 ALA A CA  1 
ATOM   1707 C  C   . ALA A 1 244 ? -14.746 -43.302 -16.304 1.00 36.27  ?  244 ALA A C   1 
ATOM   1708 O  O   . ALA A 1 244 ? -14.812 -43.087 -15.088 1.00 36.12  ?  244 ALA A O   1 
ATOM   1709 C  CB  . ALA A 1 244 ? -15.110 -45.566 -17.317 1.00 32.47  ?  244 ALA A CB  1 
ATOM   1710 N  N   . LEU A 1 245 ? -13.786 -42.775 -17.061 1.00 34.91  ?  245 LEU A N   1 
ATOM   1711 C  CA  . LEU A 1 245 ? -12.729 -41.970 -16.449 1.00 33.17  ?  245 LEU A CA  1 
ATOM   1712 C  C   . LEU A 1 245 ? -13.285 -40.678 -15.861 1.00 36.97  ?  245 LEU A C   1 
ATOM   1713 O  O   . LEU A 1 245 ? -12.903 -40.273 -14.757 1.00 36.07  ?  245 LEU A O   1 
ATOM   1714 C  CB  . LEU A 1 245 ? -11.648 -41.648 -17.478 1.00 35.01  ?  245 LEU A CB  1 
ATOM   1715 C  CG  . LEU A 1 245 ? -10.450 -40.840 -16.959 1.00 36.76  ?  245 LEU A CG  1 
ATOM   1716 C  CD1 . LEU A 1 245 ? -9.852  -41.517 -15.729 1.00 33.90  ?  245 LEU A CD1 1 
ATOM   1717 C  CD2 . LEU A 1 245 ? -9.419  -40.659 -18.061 1.00 36.43  ?  245 LEU A CD2 1 
ATOM   1718 N  N   . SER A 1 246 ? -14.177 -40.002 -16.585 1.00 35.10  ?  246 SER A N   1 
ATOM   1719 C  CA  . SER A 1 246 ? -14.640 -38.711 -16.090 1.00 37.39  ?  246 SER A CA  1 
ATOM   1720 C  C   . SER A 1 246 ? -15.626 -38.865 -14.934 1.00 37.23  ?  246 SER A C   1 
ATOM   1721 O  O   . SER A 1 246 ? -15.701 -37.986 -14.065 1.00 36.38  ?  246 SER A O   1 
ATOM   1722 C  CB  . SER A 1 246 ? -15.244 -37.889 -17.225 1.00 41.65  ?  246 SER A CB  1 
ATOM   1723 O  OG  . SER A 1 246 ? -16.314 -38.567 -17.817 1.00 47.88  ?  246 SER A OG  1 
ATOM   1724 N  N   . LEU A 1 247 ? -16.375 -39.972 -14.886 1.00 34.56  ?  247 LEU A N   1 
ATOM   1725 C  CA  . LEU A 1 247 ? -17.214 -40.220 -13.723 1.00 34.70  ?  247 LEU A CA  1 
ATOM   1726 C  C   . LEU A 1 247 ? -16.362 -40.561 -12.512 1.00 35.71  ?  247 LEU A C   1 
ATOM   1727 O  O   . LEU A 1 247 ? -16.628 -40.077 -11.402 1.00 35.09  ?  247 LEU A O   1 
ATOM   1728 C  CB  . LEU A 1 247 ? -18.216 -41.343 -14.014 1.00 39.07  ?  247 LEU A CB  1 
ATOM   1729 C  CG  . LEU A 1 247 ? -19.408 -40.974 -14.897 1.00 38.43  ?  247 LEU A CG  1 
ATOM   1730 C  CD1 . LEU A 1 247 ? -20.325 -42.182 -15.108 1.00 45.08  ?  247 LEU A CD1 1 
ATOM   1731 C  CD2 . LEU A 1 247 ? -20.197 -39.820 -14.275 1.00 38.80  ?  247 LEU A CD2 1 
ATOM   1732 N  N   . PHE A 1 248 ? -15.314 -41.370 -12.707 1.00 32.36  ?  248 PHE A N   1 
ATOM   1733 C  CA  . PHE A 1 248 ? -14.430 -41.691 -11.596 1.00 33.51  ?  248 PHE A CA  1 
ATOM   1734 C  C   . PHE A 1 248 ? -13.800 -40.428 -11.040 1.00 32.38  ?  248 PHE A C   1 
ATOM   1735 O  O   . PHE A 1 248 ? -13.857 -40.181 -9.835  1.00 32.92  ?  248 PHE A O   1 
ATOM   1736 C  CB  . PHE A 1 248 ? -13.338 -42.676 -12.019 1.00 34.29  ?  248 PHE A CB  1 
ATOM   1737 C  CG  . PHE A 1 248 ? -12.433 -43.079 -10.887 1.00 33.18  ?  248 PHE A CG  1 
ATOM   1738 C  CD1 . PHE A 1 248 ? -11.343 -42.290 -10.528 1.00 35.47  ?  248 PHE A CD1 1 
ATOM   1739 C  CD2 . PHE A 1 248 ? -12.679 -44.228 -10.167 1.00 34.25  ?  248 PHE A CD2 1 
ATOM   1740 C  CE1 . PHE A 1 248 ? -10.525 -42.654 -9.482  1.00 33.19  ?  248 PHE A CE1 1 
ATOM   1741 C  CE2 . PHE A 1 248 ? -11.877 -44.589 -9.115  1.00 35.46  ?  248 PHE A CE2 1 
ATOM   1742 C  CZ  . PHE A 1 248 ? -10.794 -43.806 -8.766  1.00 36.03  ?  248 PHE A CZ  1 
ATOM   1743 N  N   . GLY A 1 249 ? -13.189 -39.624 -11.908 1.00 32.46  ?  249 GLY A N   1 
ATOM   1744 C  CA  . GLY A 1 249 ? -12.455 -38.461 -11.432 1.00 32.88  ?  249 GLY A CA  1 
ATOM   1745 C  C   . GLY A 1 249 ? -13.366 -37.427 -10.800 1.00 34.12  ?  249 GLY A C   1 
ATOM   1746 O  O   . GLY A 1 249 ? -13.120 -36.971 -9.680  1.00 33.41  ?  249 GLY A O   1 
ATOM   1747 N  N   . ALA A 1 250 ? -14.449 -37.071 -11.495 1.00 31.41  ?  250 ALA A N   1 
ATOM   1748 C  CA  . ALA A 1 250 ? -15.365 -36.067 -10.972 1.00 32.27  ?  250 ALA A CA  1 
ATOM   1749 C  C   . ALA A 1 250 ? -16.010 -36.525 -9.671  1.00 34.09  ?  250 ALA A C   1 
ATOM   1750 O  O   . ALA A 1 250 ? -16.132 -35.741 -8.722  1.00 33.43  ?  250 ALA A O   1 
ATOM   1751 C  CB  . ALA A 1 250 ? -16.433 -35.738 -12.013 1.00 35.13  ?  250 ALA A CB  1 
ATOM   1752 N  N   . GLY A 1 251 ? -16.430 -37.791 -9.601  1.00 33.48  ?  251 GLY A N   1 
ATOM   1753 C  CA  . GLY A 1 251 ? -17.077 -38.266 -8.389  1.00 31.15  ?  251 GLY A CA  1 
ATOM   1754 C  C   . GLY A 1 251 ? -16.119 -38.356 -7.213  1.00 32.16  ?  251 GLY A C   1 
ATOM   1755 O  O   . GLY A 1 251 ? -16.424 -37.893 -6.110  1.00 29.38  ?  251 GLY A O   1 
ATOM   1756 N  N   . ALA A 1 252 ? -14.945 -38.954 -7.430  1.00 27.11  ?  252 ALA A N   1 
ATOM   1757 C  CA  . ALA A 1 252 ? -14.021 -39.166 -6.320  1.00 28.43  ?  252 ALA A CA  1 
ATOM   1758 C  C   . ALA A 1 252 ? -13.522 -37.837 -5.763  1.00 30.95  ?  252 ALA A C   1 
ATOM   1759 O  O   . ALA A 1 252 ? -13.451 -37.658 -4.540  1.00 29.19  ?  252 ALA A O   1 
ATOM   1760 C  CB  . ALA A 1 252 ? -12.830 -40.021 -6.761  1.00 29.19  ?  252 ALA A CB  1 
ATOM   1761 N  N   . VAL A 1 253 ? -13.182 -36.893 -6.647  1.00 29.70  ?  253 VAL A N   1 
ATOM   1762 C  CA  . VAL A 1 253 ? -12.638 -35.613 -6.185  1.00 30.68  ?  253 VAL A CA  1 
ATOM   1763 C  C   . VAL A 1 253 ? -13.704 -34.794 -5.463  1.00 29.40  ?  253 VAL A C   1 
ATOM   1764 O  O   . VAL A 1 253 ? -13.395 -34.082 -4.499  1.00 28.08  ?  253 VAL A O   1 
ATOM   1765 C  CB  . VAL A 1 253 ? -12.021 -34.809 -7.349  1.00 28.93  ?  253 VAL A CB  1 
ATOM   1766 C  CG1 . VAL A 1 253 ? -13.093 -34.092 -8.192  1.00 29.66  ?  253 VAL A CG1 1 
ATOM   1767 C  CG2 . VAL A 1 253 ? -10.999 -33.769 -6.804  1.00 32.55  ?  253 VAL A CG2 1 
ATOM   1768 N  N   . SER A 1 254 ? -14.965 -34.882 -5.899  1.00 27.69  ?  254 SER A N   1 
ATOM   1769 C  CA  . SER A 1 254 ? -16.021 -34.071 -5.297  1.00 29.52  ?  254 SER A CA  1 
ATOM   1770 C  C   . SER A 1 254 ? -16.456 -34.637 -3.951  1.00 27.62  ?  254 SER A C   1 
ATOM   1771 O  O   . SER A 1 254 ? -16.619 -33.884 -2.977  1.00 26.26  ?  254 SER A O   1 
ATOM   1772 C  CB  . SER A 1 254 ? -17.214 -33.976 -6.248  1.00 29.29  ?  254 SER A CB  1 
ATOM   1773 O  OG  . SER A 1 254 ? -16.878 -33.237 -7.418  1.00 29.18  ?  254 SER A OG  1 
ATOM   1774 N  N   . THR A 1 255 ? -16.608 -35.962 -3.863  1.00 28.09  ?  255 THR A N   1 
ATOM   1775 C  CA  . THR A 1 255 ? -17.009 -36.565 -2.592  1.00 27.14  ?  255 THR A CA  1 
ATOM   1776 C  C   . THR A 1 255 ? -15.887 -36.477 -1.568  1.00 27.65  ?  255 THR A C   1 
ATOM   1777 O  O   . THR A 1 255 ? -16.139 -36.203 -0.387  1.00 28.22  ?  255 THR A O   1 
ATOM   1778 C  CB  . THR A 1 255 ? -17.440 -38.019 -2.785  1.00 26.72  ?  255 THR A CB  1 
ATOM   1779 O  OG1 . THR A 1 255 ? -16.389 -38.777 -3.395  1.00 28.51  ?  255 THR A OG1 1 
ATOM   1780 C  CG2 . THR A 1 255 ? -18.704 -38.106 -3.664  1.00 28.21  ?  255 THR A CG2 1 
ATOM   1781 N  N   . SER A 1 256 ? -14.644 -36.708 -1.991  1.00 24.56  ?  256 SER A N   1 
ATOM   1782 C  CA  . SER A 1 256 ? -13.535 -36.604 -1.045  1.00 27.44  ?  256 SER A CA  1 
ATOM   1783 C  C   . SER A 1 256 ? -13.426 -35.185 -0.498  1.00 28.65  ?  256 SER A C   1 
ATOM   1784 O  O   . SER A 1 256 ? -13.285 -34.989 0.712   1.00 27.52  ?  256 SER A O   1 
ATOM   1785 C  CB  . SER A 1 256 ? -12.222 -37.019 -1.699  1.00 30.58  ?  256 SER A CB  1 
ATOM   1786 O  OG  . SER A 1 256 ? -11.130 -36.890 -0.779  1.00 32.86  ?  256 SER A OG  1 
ATOM   1787 N  N   . ALA A 1 257 ? -13.517 -34.172 -1.379  1.00 27.78  ?  257 ALA A N   1 
ATOM   1788 C  CA  . ALA A 1 257 ? -13.341 -32.796 -0.916  1.00 28.53  ?  257 ALA A CA  1 
ATOM   1789 C  C   . ALA A 1 257 ? -14.499 -32.366 -0.029  1.00 27.29  ?  257 ALA A C   1 
ATOM   1790 O  O   . ALA A 1 257 ? -14.286 -31.746 1.019   1.00 27.42  ?  257 ALA A O   1 
ATOM   1791 C  CB  . ALA A 1 257 ? -13.189 -31.827 -2.104  1.00 26.26  ?  257 ALA A CB  1 
ATOM   1792 N  N   . PHE A 1 258 ? -15.736 -32.697 -0.416  1.00 26.97  ?  258 PHE A N   1 
ATOM   1793 C  CA  . PHE A 1 258 ? -16.865 -32.344 0.436   1.00 25.40  ?  258 PHE A CA  1 
ATOM   1794 C  C   . PHE A 1 258 ? -16.750 -33.011 1.798   1.00 27.06  ?  258 PHE A C   1 
ATOM   1795 O  O   . PHE A 1 258 ? -16.957 -32.365 2.833   1.00 27.40  ?  258 PHE A O   1 
ATOM   1796 C  CB  . PHE A 1 258 ? -18.203 -32.723 -0.206  1.00 29.50  ?  258 PHE A CB  1 
ATOM   1797 C  CG  . PHE A 1 258 ? -19.351 -32.648 0.769   1.00 29.79  ?  258 PHE A CG  1 
ATOM   1798 C  CD1 . PHE A 1 258 ? -19.595 -31.465 1.471   1.00 30.01  ?  258 PHE A CD1 1 
ATOM   1799 C  CD2 . PHE A 1 258 ? -20.160 -33.736 1.004   1.00 30.41  ?  258 PHE A CD2 1 
ATOM   1800 C  CE1 . PHE A 1 258 ? -20.631 -31.391 2.398   1.00 29.14  ?  258 PHE A CE1 1 
ATOM   1801 C  CE2 . PHE A 1 258 ? -21.209 -33.660 1.904   1.00 31.27  ?  258 PHE A CE2 1 
ATOM   1802 C  CZ  . PHE A 1 258 ? -21.438 -32.485 2.605   1.00 31.22  ?  258 PHE A CZ  1 
ATOM   1803 N  N   . LEU A 1 259 ? -16.414 -34.302 1.829   1.00 23.80  ?  259 LEU A N   1 
ATOM   1804 C  CA  . LEU A 1 259 ? -16.298 -34.982 3.112   1.00 26.31  ?  259 LEU A CA  1 
ATOM   1805 C  C   . LEU A 1 259 ? -15.223 -34.331 3.971   1.00 24.64  ?  259 LEU A C   1 
ATOM   1806 O  O   . LEU A 1 259 ? -15.375 -34.226 5.190   1.00 26.28  ?  259 LEU A O   1 
ATOM   1807 C  CB  . LEU A 1 259 ? -15.992 -36.474 2.901   1.00 24.76  ?  259 LEU A CB  1 
ATOM   1808 C  CG  . LEU A 1 259 ? -15.894 -37.361 4.147   1.00 28.92  ?  259 LEU A CG  1 
ATOM   1809 C  CD1 . LEU A 1 259 ? -17.132 -37.277 5.038   1.00 27.70  ?  259 LEU A CD1 1 
ATOM   1810 C  CD2 . LEU A 1 259 ? -15.651 -38.828 3.737   1.00 27.50  ?  259 LEU A CD2 1 
ATOM   1811 N  N   . GLN A 1 260 ? -14.127 -33.874 3.361   1.00 23.81  ?  260 GLN A N   1 
ATOM   1812 C  CA  . GLN A 1 260 ? -13.116 -33.196 4.166   1.00 24.38  ?  260 GLN A CA  1 
ATOM   1813 C  C   . GLN A 1 260 ? -13.671 -31.927 4.802   1.00 25.18  ?  260 GLN A C   1 
ATOM   1814 O  O   . GLN A 1 260 ? -13.404 -31.642 5.977   1.00 27.95  ?  260 GLN A O   1 
ATOM   1815 C  CB  . GLN A 1 260 ? -11.887 -32.872 3.318   1.00 28.61  ?  260 GLN A CB  1 
ATOM   1816 C  CG  . GLN A 1 260 ? -11.078 -34.105 2.918   1.00 28.93  ?  260 GLN A CG  1 
ATOM   1817 C  CD  . GLN A 1 260 ? -10.050 -33.769 1.863   1.00 34.00  ?  260 GLN A CD  1 
ATOM   1818 O  OE1 . GLN A 1 260 ? -9.130  -33.006 2.130   1.00 34.04  ?  260 GLN A OE1 1 
ATOM   1819 N  NE2 . GLN A 1 260 ? -10.212 -34.317 0.643   1.00 35.23  ?  260 GLN A NE2 1 
ATOM   1820 N  N   . HIS A 1 261 ? -14.434 -31.138 4.041   1.00 23.92  ?  261 HIS A N   1 
ATOM   1821 C  CA  . HIS A 1 261 ? -15.048 -29.936 4.604   1.00 28.11  ?  261 HIS A CA  1 
ATOM   1822 C  C   . HIS A 1 261 ? -16.047 -30.282 5.704   1.00 29.39  ?  261 HIS A C   1 
ATOM   1823 O  O   . HIS A 1 261 ? -16.119 -29.594 6.736   1.00 26.49  ?  261 HIS A O   1 
ATOM   1824 C  CB  . HIS A 1 261 ? -15.723 -29.134 3.488   1.00 29.02  ?  261 HIS A CB  1 
ATOM   1825 C  CG  . HIS A 1 261 ? -14.755 -28.344 2.659   1.00 31.13  ?  261 HIS A CG  1 
ATOM   1826 N  ND1 . HIS A 1 261 ? -14.619 -26.976 2.764   1.00 29.64  ?  261 HIS A ND1 1 
ATOM   1827 C  CD2 . HIS A 1 261 ? -13.858 -28.740 1.725   1.00 29.58  ?  261 HIS A CD2 1 
ATOM   1828 C  CE1 . HIS A 1 261 ? -13.690 -26.563 1.922   1.00 29.08  ?  261 HIS A CE1 1 
ATOM   1829 N  NE2 . HIS A 1 261 ? -13.209 -27.614 1.282   1.00 29.70  ?  261 HIS A NE2 1 
ATOM   1830 N  N   . ALA A 1 262 ? -16.813 -31.359 5.517   1.00 24.73  ?  262 ALA A N   1 
ATOM   1831 C  CA  . ALA A 1 262 ? -17.767 -31.759 6.549   1.00 27.65  ?  262 ALA A CA  1 
ATOM   1832 C  C   . ALA A 1 262 ? -17.044 -32.184 7.818   1.00 27.00  ?  262 ALA A C   1 
ATOM   1833 O  O   . ALA A 1 262 ? -17.504 -31.902 8.934   1.00 26.08  ?  262 ALA A O   1 
ATOM   1834 C  CB  . ALA A 1 262 ? -18.664 -32.897 6.029   1.00 26.80  ?  262 ALA A CB  1 
ATOM   1835 N  N   . ILE A 1 263 ? -15.914 -32.876 7.670   1.00 25.05  ?  263 ILE A N   1 
ATOM   1836 C  CA  . ILE A 1 263 ? -15.155 -33.322 8.833   1.00 25.48  ?  263 ILE A CA  1 
ATOM   1837 C  C   . ILE A 1 263 ? -14.633 -32.126 9.621   1.00 26.49  ?  263 ILE A C   1 
ATOM   1838 O  O   . ILE A 1 263 ? -14.671 -32.110 10.858  1.00 28.07  ?  263 ILE A O   1 
ATOM   1839 C  CB  . ILE A 1 263 ? -14.013 -34.249 8.385   1.00 27.43  ?  263 ILE A CB  1 
ATOM   1840 C  CG1 . ILE A 1 263 ? -14.600 -35.596 7.929   1.00 28.39  ?  263 ILE A CG1 1 
ATOM   1841 C  CG2 . ILE A 1 263 ? -12.975 -34.408 9.502   1.00 26.96  ?  263 ILE A CG2 1 
ATOM   1842 C  CD1 . ILE A 1 263 ? -13.563 -36.520 7.323   1.00 27.23  ?  263 ILE A CD1 1 
ATOM   1843 N  N   . ILE A 1 264 ? -14.112 -31.123 8.920   1.00 24.63  ?  264 ILE A N   1 
ATOM   1844 C  CA  . ILE A 1 264 ? -13.628 -29.917 9.596   1.00 27.38  ?  264 ILE A CA  1 
ATOM   1845 C  C   . ILE A 1 264 ? -14.743 -29.280 10.420  1.00 28.97  ?  264 ILE A C   1 
ATOM   1846 O  O   . ILE A 1 264 ? -14.520 -28.845 11.558  1.00 30.88  ?  264 ILE A O   1 
ATOM   1847 C  CB  . ILE A 1 264 ? -13.036 -28.937 8.568   1.00 25.71  ?  264 ILE A CB  1 
ATOM   1848 C  CG1 . ILE A 1 264 ? -11.724 -29.514 8.022   1.00 26.13  ?  264 ILE A CG1 1 
ATOM   1849 C  CG2 . ILE A 1 264 ? -12.826 -27.541 9.221   1.00 31.01  ?  264 ILE A CG2 1 
ATOM   1850 C  CD1 . ILE A 1 264 ? -11.180 -28.810 6.797   1.00 30.35  ?  264 ILE A CD1 1 
ATOM   1851 N  N   . ALA A 1 265 ? -15.959 -29.218 9.866   1.00 27.82  ?  265 ALA A N   1 
ATOM   1852 C  CA  . ALA A 1 265 ? -17.071 -28.616 10.596  1.00 27.22  ?  265 ALA A CA  1 
ATOM   1853 C  C   . ALA A 1 265 ? -17.365 -29.381 11.878  1.00 29.26  ?  265 ALA A C   1 
ATOM   1854 O  O   . ALA A 1 265 ? -17.533 -28.775 12.943  1.00 30.02  ?  265 ALA A O   1 
ATOM   1855 C  CB  . ALA A 1 265 ? -18.316 -28.554 9.711   1.00 29.11  ?  265 ALA A CB  1 
ATOM   1856 N  N   . LEU A 1 266 ? -17.427 -30.721 11.799  1.00 27.42  ?  266 LEU A N   1 
ATOM   1857 C  CA  . LEU A 1 266 ? -17.727 -31.526 12.987  1.00 29.75  ?  266 LEU A CA  1 
ATOM   1858 C  C   . LEU A 1 266 ? -16.572 -31.508 13.985  1.00 31.00  ?  266 LEU A C   1 
ATOM   1859 O  O   . LEU A 1 266 ? -16.789 -31.670 15.197  1.00 31.75  ?  266 LEU A O   1 
ATOM   1860 C  CB  . LEU A 1 266 ? -18.045 -32.985 12.597  1.00 26.35  ?  266 LEU A CB  1 
ATOM   1861 C  CG  . LEU A 1 266 ? -19.214 -33.228 11.646  1.00 29.24  ?  266 LEU A CG  1 
ATOM   1862 C  CD1 . LEU A 1 266 ? -19.450 -34.720 11.433  1.00 33.68  ?  266 LEU A CD1 1 
ATOM   1863 C  CD2 . LEU A 1 266 ? -20.487 -32.562 12.185  1.00 30.75  ?  266 LEU A CD2 1 
ATOM   1864 N  N   . ALA A 1 267 ? -15.340 -31.324 13.506  1.00 28.41  ?  267 ALA A N   1 
ATOM   1865 C  CA  . ALA A 1 267 ? -14.220 -31.206 14.436  1.00 29.54  ?  267 ALA A CA  1 
ATOM   1866 C  C   . ALA A 1 267 ? -14.226 -29.851 15.135  1.00 30.55  ?  267 ALA A C   1 
ATOM   1867 O  O   . ALA A 1 267 ? -13.903 -29.759 16.323  1.00 31.81  ?  267 ALA A O   1 
ATOM   1868 C  CB  . ALA A 1 267 ? -12.894 -31.414 13.707  1.00 27.70  ?  267 ALA A CB  1 
ATOM   1869 N  N   . GLN A 1 268 ? -14.567 -28.787 14.413  1.00 28.67  ?  268 GLN A N   1 
ATOM   1870 C  CA  . GLN A 1 268 ? -14.564 -27.451 14.996  1.00 30.17  ?  268 GLN A CA  1 
ATOM   1871 C  C   . GLN A 1 268 ? -15.816 -27.169 15.812  1.00 31.96  ?  268 GLN A C   1 
ATOM   1872 O  O   . GLN A 1 268 ? -15.797 -26.284 16.667  1.00 30.24  ?  268 GLN A O   1 
ATOM   1873 C  CB  . GLN A 1 268 ? -14.445 -26.411 13.887  1.00 32.74  ?  268 GLN A CB  1 
ATOM   1874 C  CG  . GLN A 1 268 ? -13.081 -26.387 13.257  1.00 30.67  ?  268 GLN A CG  1 
ATOM   1875 C  CD  . GLN A 1 268 ? -12.100 -25.639 14.122  1.00 37.93  ?  268 GLN A CD  1 
ATOM   1876 O  OE1 . GLN A 1 268 ? -11.363 -26.230 14.918  1.00 37.86  ?  268 GLN A OE1 1 
ATOM   1877 N  NE2 . GLN A 1 268 ? -12.092 -24.320 13.982  1.00 40.15  ?  268 GLN A NE2 1 
ATOM   1878 N  N   . GLN A 1 269 ? -16.903 -27.897 15.565  1.00 30.49  ?  269 GLN A N   1 
ATOM   1879 C  CA  . GLN A 1 269 ? -18.184 -27.658 16.225  1.00 31.39  ?  269 GLN A CA  1 
ATOM   1880 C  C   . GLN A 1 269 ? -18.659 -28.991 16.783  1.00 31.04  ?  269 GLN A C   1 
ATOM   1881 O  O   . GLN A 1 269 ? -19.564 -29.630 16.227  1.00 29.91  ?  269 GLN A O   1 
ATOM   1882 C  CB  . GLN A 1 269 ? -19.195 -27.040 15.259  1.00 31.66  ?  269 GLN A CB  1 
ATOM   1883 C  CG  . GLN A 1 269 ? -18.784 -25.657 14.749  1.00 33.00  ?  269 GLN A CG  1 
ATOM   1884 C  CD  . GLN A 1 269 ? -19.906 -24.926 14.005  1.00 34.01  ?  269 GLN A CD  1 
ATOM   1885 O  OE1 . GLN A 1 269 ? -21.050 -24.849 14.478  1.00 38.27  ?  269 GLN A OE1 1 
ATOM   1886 N  NE2 . GLN A 1 269 ? -19.581 -24.379 12.853  1.00 28.01  ?  269 GLN A NE2 1 
ATOM   1887 N  N   . PRO A 1 270 ? -18.055 -29.445 17.884  1.00 31.27  ?  270 PRO A N   1 
ATOM   1888 C  CA  . PRO A 1 270 ? -18.379 -30.784 18.407  1.00 31.10  ?  270 PRO A CA  1 
ATOM   1889 C  C   . PRO A 1 270 ? -19.821 -30.934 18.874  1.00 33.05  ?  270 PRO A C   1 
ATOM   1890 O  O   . PRO A 1 270 ? -20.286 -32.070 19.035  1.00 32.62  ?  270 PRO A O   1 
ATOM   1891 C  CB  . PRO A 1 270 ? -17.393 -30.946 19.573  1.00 32.33  ?  270 PRO A CB  1 
ATOM   1892 C  CG  . PRO A 1 270 ? -17.051 -29.532 19.971  1.00 31.37  ?  270 PRO A CG  1 
ATOM   1893 C  CD  . PRO A 1 270 ? -17.013 -28.776 18.682  1.00 32.47  ?  270 PRO A CD  1 
ATOM   1894 N  N   . GLU A 1 271 ? -20.551 -29.833 19.092  1.00 29.93  ?  271 GLU A N   1 
ATOM   1895 C  CA  . GLU A 1 271 ? -21.971 -29.957 19.417  1.00 33.11  ?  271 GLU A CA  1 
ATOM   1896 C  C   . GLU A 1 271 ? -22.752 -30.575 18.262  1.00 31.58  ?  271 GLU A C   1 
ATOM   1897 O  O   . GLU A 1 271 ? -23.780 -31.230 18.485  1.00 32.32  ?  271 GLU A O   1 
ATOM   1898 C  CB  . GLU A 1 271 ? -22.544 -28.583 19.807  1.00 31.83  ?  271 GLU A CB  1 
ATOM   1899 C  CG  . GLU A 1 271 ? -22.725 -27.621 18.641  1.00 34.03  ?  271 GLU A CG  1 
ATOM   1900 C  CD  . GLU A 1 271 ? -21.471 -26.823 18.308  1.00 33.56  ?  271 GLU A CD  1 
ATOM   1901 O  OE1 . GLU A 1 271 ? -20.381 -27.126 18.853  1.00 32.94  ?  271 GLU A OE1 1 
ATOM   1902 O  OE2 . GLU A 1 271 ? -21.589 -25.896 17.479  1.00 36.70  ?  271 GLU A OE2 1 
ATOM   1903 N  N   . LEU A 1 272 ? -22.268 -30.402 17.026  1.00 29.25  ?  272 LEU A N   1 
ATOM   1904 C  CA  . LEU A 1 272 ? -22.915 -31.022 15.875  1.00 30.95  ?  272 LEU A CA  1 
ATOM   1905 C  C   . LEU A 1 272 ? -22.738 -32.532 15.898  1.00 31.01  ?  272 LEU A C   1 
ATOM   1906 O  O   . LEU A 1 272 ? -23.664 -33.280 15.552  1.00 30.38  ?  272 LEU A O   1 
ATOM   1907 C  CB  . LEU A 1 272 ? -22.353 -30.447 14.568  1.00 31.52  ?  272 LEU A CB  1 
ATOM   1908 C  CG  . LEU A 1 272 ? -22.460 -28.936 14.346  1.00 31.93  ?  272 LEU A CG  1 
ATOM   1909 C  CD1 . LEU A 1 272 ? -21.749 -28.570 13.034  1.00 28.49  ?  272 LEU A CD1 1 
ATOM   1910 C  CD2 . LEU A 1 272 ? -23.940 -28.501 14.323  1.00 30.20  ?  272 LEU A CD2 1 
ATOM   1911 N  N   . ALA A 1 273 ? -21.554 -32.996 16.292  1.00 27.96  ?  273 ALA A N   1 
ATOM   1912 C  CA  . ALA A 1 273 ? -21.331 -34.434 16.417  1.00 32.30  ?  273 ALA A CA  1 
ATOM   1913 C  C   . ALA A 1 273 ? -22.137 -35.015 17.574  1.00 32.92  ?  273 ALA A C   1 
ATOM   1914 O  O   . ALA A 1 273 ? -22.597 -36.159 17.499  1.00 31.78  ?  273 ALA A O   1 
ATOM   1915 C  CB  . ALA A 1 273 ? -19.840 -34.714 16.597  1.00 31.25  ?  273 ALA A CB  1 
ATOM   1916 N  N   . ASP A 1 274 ? -22.323 -34.242 18.654  1.00 32.74  ?  274 ASP A N   1 
ATOM   1917 C  CA  . ASP A 1 274 ? -23.206 -34.686 19.730  1.00 31.70  ?  274 ASP A CA  1 
ATOM   1918 C  C   . ASP A 1 274 ? -24.630 -34.857 19.222  1.00 30.92  ?  274 ASP A C   1 
ATOM   1919 O  O   . ASP A 1 274 ? -25.308 -35.829 19.576  1.00 32.36  ?  274 ASP A O   1 
ATOM   1920 C  CB  . ASP A 1 274 ? -23.174 -33.700 20.900  1.00 32.13  ?  274 ASP A CB  1 
ATOM   1921 C  CG  . ASP A 1 274 ? -22.078 -34.008 21.910  1.00 35.96  ?  274 ASP A CG  1 
ATOM   1922 O  OD1 . ASP A 1 274 ? -21.377 -35.028 21.755  1.00 38.75  ?  274 ASP A OD1 1 
ATOM   1923 O  OD2 . ASP A 1 274 ? -21.906 -33.213 22.867  1.00 34.66  ?  274 ASP A OD2 1 
ATOM   1924 N  N   . ARG A 1 275 ? -25.091 -33.928 18.377  1.00 29.60  ?  275 ARG A N   1 
ATOM   1925 C  CA  . ARG A 1 275 ? -26.419 -34.047 17.781  1.00 32.81  ?  275 ARG A CA  1 
ATOM   1926 C  C   . ARG A 1 275 ? -26.539 -35.326 16.962  1.00 36.29  ?  275 ARG A C   1 
ATOM   1927 O  O   . ARG A 1 275 ? -27.540 -36.049 17.069  1.00 32.99  ?  275 ARG A O   1 
ATOM   1928 C  CB  . ARG A 1 275 ? -26.722 -32.829 16.898  1.00 30.18  ?  275 ARG A CB  1 
ATOM   1929 C  CG  . ARG A 1 275 ? -28.060 -32.941 16.106  1.00 31.82  ?  275 ARG A CG  1 
ATOM   1930 C  CD  . ARG A 1 275 ? -29.250 -32.831 17.048  1.00 34.21  ?  275 ARG A CD  1 
ATOM   1931 N  NE  . ARG A 1 275 ? -30.543 -32.844 16.370  1.00 34.11  ?  275 ARG A NE  1 
ATOM   1932 C  CZ  . ARG A 1 275 ? -31.045 -31.811 15.711  1.00 35.85  ?  275 ARG A CZ  1 
ATOM   1933 N  NH1 . ARG A 1 275 ? -30.343 -30.696 15.531  1.00 30.11  ?  275 ARG A NH1 1 
ATOM   1934 N  NH2 . ARG A 1 275 ? -32.282 -31.890 15.223  1.00 34.07  ?  275 ARG A NH2 1 
ATOM   1935 N  N   . LEU A 1 276 ? -25.522 -35.625 16.141  1.00 32.30  ?  276 LEU A N   1 
ATOM   1936 C  CA  . LEU A 1 276 ? -25.590 -36.797 15.271  1.00 34.31  ?  276 LEU A CA  1 
ATOM   1937 C  C   . LEU A 1 276 ? -25.577 -38.090 16.082  1.00 33.27  ?  276 LEU A C   1 
ATOM   1938 O  O   . LEU A 1 276 ? -26.297 -39.038 15.752  1.00 36.07  ?  276 LEU A O   1 
ATOM   1939 C  CB  . LEU A 1 276 ? -24.434 -36.774 14.263  1.00 30.95  ?  276 LEU A CB  1 
ATOM   1940 C  CG  . LEU A 1 276 ? -24.527 -35.650 13.217  1.00 36.90  ?  276 LEU A CG  1 
ATOM   1941 C  CD1 . LEU A 1 276 ? -23.336 -35.721 12.281  1.00 32.98  ?  276 LEU A CD1 1 
ATOM   1942 C  CD2 . LEU A 1 276 ? -25.845 -35.712 12.419  1.00 34.25  ?  276 LEU A CD2 1 
ATOM   1943 N  N   . ARG A 1 277 ? -24.786 -38.140 17.160  1.00 32.44  ?  277 ARG A N   1 
ATOM   1944 C  CA  . ARG A 1 277 ? -24.796 -39.320 18.018  1.00 33.74  ?  277 ARG A CA  1 
ATOM   1945 C  C   . ARG A 1 277 ? -26.124 -39.464 18.750  1.00 37.33  ?  277 ARG A C   1 
ATOM   1946 O  O   . ARG A 1 277 ? -26.609 -40.583 18.938  1.00 31.30  ?  277 ARG A O   1 
ATOM   1947 C  CB  . ARG A 1 277 ? -23.644 -39.267 19.019  1.00 31.96  ?  277 ARG A CB  1 
ATOM   1948 C  CG  . ARG A 1 277 ? -22.271 -39.537 18.411  1.00 33.05  ?  277 ARG A CG  1 
ATOM   1949 C  CD  . ARG A 1 277 ? -21.209 -39.651 19.510  1.00 36.28  ?  277 ARG A CD  1 
ATOM   1950 N  NE  . ARG A 1 277 ? -20.825 -38.337 20.012  1.00 34.45  ?  277 ARG A NE  1 
ATOM   1951 C  CZ  . ARG A 1 277 ? -19.949 -37.534 19.424  1.00 37.15  ?  277 ARG A CZ  1 
ATOM   1952 N  NH1 . ARG A 1 277 ? -19.290 -37.908 18.333  1.00 31.48  ?  277 ARG A NH1 1 
ATOM   1953 N  NH2 . ARG A 1 277 ? -19.721 -36.330 19.945  1.00 33.90  ?  277 ARG A NH2 1 
ATOM   1954 N  N   . ALA A 1 278 ? -26.726 -38.351 19.182  1.00 32.71  ?  278 ALA A N   1 
ATOM   1955 C  CA  . ALA A 1 278 ? -27.974 -38.454 19.935  1.00 37.51  ?  278 ALA A CA  1 
ATOM   1956 C  C   . ALA A 1 278 ? -29.171 -38.748 19.039  1.00 35.73  ?  278 ALA A C   1 
ATOM   1957 O  O   . ALA A 1 278 ? -30.114 -39.413 19.476  1.00 38.84  ?  278 ALA A O   1 
ATOM   1958 C  CB  . ALA A 1 278 ? -28.219 -37.164 20.724  1.00 35.94  ?  278 ALA A CB  1 
ATOM   1959 N  N   . GLU A 1 279 ? -29.162 -38.261 17.800  1.00 33.55  ?  279 GLU A N   1 
ATOM   1960 C  CA  . GLU A 1 279 ? -30.306 -38.353 16.887  1.00 38.38  ?  279 GLU A CA  1 
ATOM   1961 C  C   . GLU A 1 279 ? -29.815 -38.838 15.532  1.00 36.54  ?  279 GLU A C   1 
ATOM   1962 O  O   . GLU A 1 279 ? -29.736 -38.062 14.567  1.00 35.15  ?  279 GLU A O   1 
ATOM   1963 C  CB  . GLU A 1 279 ? -31.014 -37.002 16.752  1.00 39.44  ?  279 GLU A CB  1 
ATOM   1964 C  CG  . GLU A 1 279 ? -32.493 -37.107 16.347  1.00 47.33  ?  279 GLU A CG  1 
ATOM   1965 C  CD  . GLU A 1 279 ? -33.104 -35.764 15.924  1.00 48.94  ?  279 GLU A CD  1 
ATOM   1966 O  OE1 . GLU A 1 279 ? -34.070 -35.758 15.122  1.00 48.53  ?  279 GLU A OE1 1 
ATOM   1967 O  OE2 . GLU A 1 279 ? -32.618 -34.711 16.391  1.00 44.82  ?  279 GLU A OE2 1 
ATOM   1968 N  N   . PRO A 1 280 ? -29.461 -40.122 15.429  1.00 37.49  ?  280 PRO A N   1 
ATOM   1969 C  CA  . PRO A 1 280 ? -28.837 -40.616 14.185  1.00 37.47  ?  280 PRO A CA  1 
ATOM   1970 C  C   . PRO A 1 280 ? -29.657 -40.354 12.941  1.00 36.85  ?  280 PRO A C   1 
ATOM   1971 O  O   . PRO A 1 280 ? -29.083 -40.180 11.859  1.00 36.45  ?  280 PRO A O   1 
ATOM   1972 C  CB  . PRO A 1 280 ? -28.677 -42.122 14.453  1.00 36.76  ?  280 PRO A CB  1 
ATOM   1973 C  CG  . PRO A 1 280 ? -28.543 -42.211 15.931  1.00 39.61  ?  280 PRO A CG  1 
ATOM   1974 C  CD  . PRO A 1 280 ? -29.457 -41.146 16.491  1.00 36.13  ?  280 PRO A CD  1 
ATOM   1975 N  N   . ALA A 1 281 ? -30.985 -40.276 13.064  1.00 35.64  ?  281 ALA A N   1 
ATOM   1976 C  CA  . ALA A 1 281 ? -31.826 -40.075 11.890  1.00 37.63  ?  281 ALA A CA  1 
ATOM   1977 C  C   . ALA A 1 281 ? -31.744 -38.660 11.330  1.00 38.25  ?  281 ALA A C   1 
ATOM   1978 O  O   . ALA A 1 281 ? -32.271 -38.414 10.239  1.00 36.93  ?  281 ALA A O   1 
ATOM   1979 C  CB  . ALA A 1 281 ? -33.284 -40.415 12.224  1.00 41.75  ?  281 ALA A CB  1 
ATOM   1980 N  N   . VAL A 1 282 ? -31.105 -37.718 12.034  1.00 35.23  ?  282 VAL A N   1 
ATOM   1981 C  CA  . VAL A 1 282 ? -30.961 -36.374 11.473  1.00 36.04  ?  282 VAL A CA  1 
ATOM   1982 C  C   . VAL A 1 282 ? -29.829 -36.297 10.456  1.00 37.00  ?  282 VAL A C   1 
ATOM   1983 O  O   . VAL A 1 282 ? -29.598 -35.225 9.869   1.00 31.40  ?  282 VAL A O   1 
ATOM   1984 C  CB  . VAL A 1 282 ? -30.765 -35.350 12.613  1.00 39.45  ?  282 VAL A CB  1 
ATOM   1985 C  CG1 . VAL A 1 282 ? -30.491 -33.965 12.054  1.00 42.23  ?  282 VAL A CG1 1 
ATOM   1986 C  CG2 . VAL A 1 282 ? -31.977 -35.322 13.533  1.00 41.98  ?  282 VAL A CG2 1 
ATOM   1987 N  N   . ILE A 1 283 ? -29.139 -37.415 10.195  1.00 34.44  ?  283 ILE A N   1 
ATOM   1988 C  CA  . ILE A 1 283 ? -27.954 -37.373 9.333   1.00 33.73  ?  283 ILE A CA  1 
ATOM   1989 C  C   . ILE A 1 283 ? -28.312 -36.821 7.956   1.00 32.37  ?  283 ILE A C   1 
ATOM   1990 O  O   . ILE A 1 283 ? -27.529 -36.080 7.350   1.00 31.26  ?  283 ILE A O   1 
ATOM   1991 C  CB  . ILE A 1 283 ? -27.284 -38.765 9.250   1.00 32.51  ?  283 ILE A CB  1 
ATOM   1992 C  CG1 . ILE A 1 283 ? -25.935 -38.668 8.522   1.00 32.68  ?  283 ILE A CG1 1 
ATOM   1993 C  CG2 . ILE A 1 283 ? -28.207 -39.825 8.601   1.00 34.36  ?  283 ILE A CG2 1 
ATOM   1994 C  CD1 . ILE A 1 283 ? -24.872 -37.950 9.316   1.00 30.48  ?  283 ILE A CD1 1 
ATOM   1995 N  N   . GLY A 1 284 ? -29.516 -37.135 7.458   1.00 34.34  ?  284 GLY A N   1 
ATOM   1996 C  CA  . GLY A 1 284 ? -29.932 -36.629 6.154   1.00 34.47  ?  284 GLY A CA  1 
ATOM   1997 C  C   . GLY A 1 284 ? -30.031 -35.113 6.109   1.00 36.71  ?  284 GLY A C   1 
ATOM   1998 O  O   . GLY A 1 284 ? -29.529 -34.465 5.179   1.00 33.00  ?  284 GLY A O   1 
ATOM   1999 N  N   . ARG A 1 285 ? -30.700 -34.524 7.105   1.00 35.08  ?  285 ARG A N   1 
ATOM   2000 C  CA  . ARG A 1 285 ? -30.774 -33.068 7.176   1.00 35.55  ?  285 ARG A CA  1 
ATOM   2001 C  C   . ARG A 1 285 ? -29.418 -32.459 7.486   1.00 32.43  ?  285 ARG A C   1 
ATOM   2002 O  O   . ARG A 1 285 ? -29.115 -31.353 7.024   1.00 33.95  ?  285 ARG A O   1 
ATOM   2003 C  CB  . ARG A 1 285 ? -31.774 -32.615 8.248   1.00 35.78  ?  285 ARG A CB  1 
ATOM   2004 C  CG  . ARG A 1 285 ? -33.162 -33.192 8.112   1.00 44.27  ?  285 ARG A CG  1 
ATOM   2005 C  CD  . ARG A 1 285 ? -34.097 -32.600 9.173   1.00 49.95  ?  285 ARG A CD  1 
ATOM   2006 N  NE  . ARG A 1 285 ? -33.831 -31.179 9.381   1.00 52.63  ?  285 ARG A NE  1 
ATOM   2007 C  CZ  . ARG A 1 285 ? -34.262 -30.209 8.579   1.00 52.31  ?  285 ARG A CZ  1 
ATOM   2008 N  NH1 . ARG A 1 285 ? -35.016 -30.468 7.519   1.00 61.23  ?  285 ARG A NH1 1 
ATOM   2009 N  NH2 . ARG A 1 285 ? -33.930 -28.947 8.847   1.00 45.54  ?  285 ARG A NH2 1 
ATOM   2010 N  N   . ALA A 1 286 ? -28.610 -33.148 8.291   1.00 32.89  ?  286 ALA A N   1 
ATOM   2011 C  CA  . ALA A 1 286 ? -27.303 -32.617 8.652   1.00 33.91  ?  286 ALA A CA  1 
ATOM   2012 C  C   . ALA A 1 286 ? -26.402 -32.519 7.430   1.00 32.40  ?  286 ALA A C   1 
ATOM   2013 O  O   . ALA A 1 286 ? -25.731 -31.501 7.226   1.00 33.04  ?  286 ALA A O   1 
ATOM   2014 C  CB  . ALA A 1 286 ? -26.661 -33.490 9.731   1.00 33.46  ?  286 ALA A CB  1 
ATOM   2015 N  N   . VAL A 1 287 ? -26.393 -33.559 6.592   1.00 30.64  ?  287 VAL A N   1 
ATOM   2016 C  CA  . VAL A 1 287 ? -25.562 -33.523 5.399   1.00 28.20  ?  287 VAL A CA  1 
ATOM   2017 C  C   . VAL A 1 287 ? -26.099 -32.488 4.430   1.00 31.83  ?  287 VAL A C   1 
ATOM   2018 O  O   . VAL A 1 287 ? -25.321 -31.817 3.746   1.00 28.08  ?  287 VAL A O   1 
ATOM   2019 C  CB  . VAL A 1 287 ? -25.460 -34.929 4.764   1.00 30.00  ?  287 VAL A CB  1 
ATOM   2020 C  CG1 . VAL A 1 287 ? -24.922 -34.849 3.329   1.00 26.64  ?  287 VAL A CG1 1 
ATOM   2021 C  CG2 . VAL A 1 287 ? -24.564 -35.803 5.609   1.00 31.56  ?  287 VAL A CG2 1 
ATOM   2022 N  N   . ASP A 1 288 ? -27.429 -32.299 4.385   1.00 30.68  ?  288 ASP A N   1 
ATOM   2023 C  CA  . ASP A 1 288 ? -27.999 -31.270 3.519   1.00 31.52  ?  288 ASP A CA  1 
ATOM   2024 C  C   . ASP A 1 288 ? -27.529 -29.871 3.927   1.00 29.50  ?  288 ASP A C   1 
ATOM   2025 O  O   . ASP A 1 288 ? -27.287 -29.011 3.070   1.00 31.26  ?  288 ASP A O   1 
ATOM   2026 C  CB  . ASP A 1 288 ? -29.525 -31.357 3.558   1.00 33.28  ?  288 ASP A CB  1 
ATOM   2027 C  CG  . ASP A 1 288 ? -30.170 -30.753 2.342   1.00 38.20  ?  288 ASP A CG  1 
ATOM   2028 O  OD1 . ASP A 1 288 ? -29.708 -31.047 1.210   1.00 38.42  ?  288 ASP A OD1 1 
ATOM   2029 O  OD2 . ASP A 1 288 ? -31.143 -29.979 2.513   1.00 42.05  ?  288 ASP A OD2 1 
ATOM   2030 N  N   . GLU A 1 289 ? -27.418 -29.615 5.230   1.00 30.07  ?  289 GLU A N   1 
ATOM   2031 C  CA  . GLU A 1 289 ? -26.914 -28.319 5.678   1.00 30.47  ?  289 GLU A CA  1 
ATOM   2032 C  C   . GLU A 1 289 ? -25.403 -28.215 5.497   1.00 30.99  ?  289 GLU A C   1 
ATOM   2033 O  O   . GLU A 1 289 ? -24.901 -27.163 5.094   1.00 30.42  ?  289 GLU A O   1 
ATOM   2034 C  CB  . GLU A 1 289 ? -27.306 -28.069 7.135   1.00 31.26  ?  289 GLU A CB  1 
ATOM   2035 C  CG  . GLU A 1 289 ? -26.584 -26.886 7.814   1.00 31.44  ?  289 GLU A CG  1 
ATOM   2036 C  CD  . GLU A 1 289 ? -27.066 -25.518 7.350   1.00 31.60  ?  289 GLU A CD  1 
ATOM   2037 O  OE1 . GLU A 1 289 ? -27.687 -25.406 6.266   1.00 32.28  ?  289 GLU A OE1 1 
ATOM   2038 O  OE2 . GLU A 1 289 ? -26.804 -24.532 8.073   1.00 30.48  ?  289 GLU A OE2 1 
ATOM   2039 N  N   . LEU A 1 290 ? -24.651 -29.287 5.790   1.00 27.52  ?  290 LEU A N   1 
ATOM   2040 C  CA  . LEU A 1 290 ? -23.215 -29.227 5.526   1.00 30.61  ?  290 LEU A CA  1 
ATOM   2041 C  C   . LEU A 1 290 ? -22.938 -28.998 4.046   1.00 27.93  ?  290 LEU A C   1 
ATOM   2042 O  O   . LEU A 1 290 ? -21.969 -28.319 3.703   1.00 29.30  ?  290 LEU A O   1 
ATOM   2043 C  CB  . LEU A 1 290 ? -22.519 -30.497 6.022   1.00 28.15  ?  290 LEU A CB  1 
ATOM   2044 C  CG  . LEU A 1 290 ? -22.595 -30.657 7.545   1.00 29.93  ?  290 LEU A CG  1 
ATOM   2045 C  CD1 . LEU A 1 290 ? -21.991 -31.990 8.010   1.00 33.90  ?  290 LEU A CD1 1 
ATOM   2046 C  CD2 . LEU A 1 290 ? -21.928 -29.463 8.250   1.00 31.78  ?  290 LEU A CD2 1 
ATOM   2047 N  N   . LEU A 1 291 ? -23.800 -29.520 3.163   1.00 28.80  ?  291 LEU A N   1 
ATOM   2048 C  CA  . LEU A 1 291 ? -23.676 -29.260 1.728   1.00 31.23  ?  291 LEU A CA  1 
ATOM   2049 C  C   . LEU A 1 291 ? -23.869 -27.780 1.407   1.00 29.23  ?  291 LEU A C   1 
ATOM   2050 O  O   . LEU A 1 291 ? -23.095 -27.194 0.639   1.00 31.14  ?  291 LEU A O   1 
ATOM   2051 C  CB  . LEU A 1 291 ? -24.689 -30.113 0.952   1.00 29.79  ?  291 LEU A CB  1 
ATOM   2052 C  CG  . LEU A 1 291 ? -24.280 -31.566 0.659   1.00 29.82  ?  291 LEU A CG  1 
ATOM   2053 C  CD1 . LEU A 1 291 ? -25.496 -32.408 0.301   1.00 30.66  ?  291 LEU A CD1 1 
ATOM   2054 C  CD2 . LEU A 1 291 ? -23.235 -31.601 -0.468  1.00 29.48  ?  291 LEU A CD2 1 
ATOM   2055 N  N   . ARG A 1 292 ? -24.911 -27.157 1.964   1.00 29.26  ?  292 ARG A N   1 
ATOM   2056 C  CA  . ARG A 1 292 ? -25.061 -25.716 1.776   1.00 30.88  ?  292 ARG A CA  1 
ATOM   2057 C  C   . ARG A 1 292 ? -23.819 -24.973 2.247   1.00 28.20  ?  292 ARG A C   1 
ATOM   2058 O  O   . ARG A 1 292 ? -23.332 -24.052 1.576   1.00 30.58  ?  292 ARG A O   1 
ATOM   2059 C  CB  . ARG A 1 292 ? -26.286 -25.186 2.530   1.00 30.91  ?  292 ARG A CB  1 
ATOM   2060 C  CG  . ARG A 1 292 ? -26.402 -23.659 2.412   1.00 31.80  ?  292 ARG A CG  1 
ATOM   2061 C  CD  . ARG A 1 292 ? -27.343 -23.010 3.456   1.00 30.89  ?  292 ARG A CD  1 
ATOM   2062 N  NE  . ARG A 1 292 ? -26.796 -23.063 4.806   1.00 31.15  ?  292 ARG A NE  1 
ATOM   2063 C  CZ  . ARG A 1 292 ? -25.970 -22.156 5.315   1.00 32.60  ?  292 ARG A CZ  1 
ATOM   2064 N  NH1 . ARG A 1 292 ? -25.567 -21.113 4.608   1.00 28.29  ?  292 ARG A NH1 1 
ATOM   2065 N  NH2 . ARG A 1 292 ? -25.532 -22.302 6.563   1.00 30.80  ?  292 ARG A NH2 1 
ATOM   2066 N  N   . TYR A 1 293 ? -23.303 -25.358 3.406   1.00 27.16  ?  293 TYR A N   1 
ATOM   2067 C  CA  . TYR A 1 293 ? -22.222 -24.606 4.043   1.00 30.73  ?  293 TYR A CA  1 
ATOM   2068 C  C   . TYR A 1 293 ? -20.886 -24.816 3.346   1.00 30.16  ?  293 TYR A C   1 
ATOM   2069 O  O   . TYR A 1 293 ? -19.994 -23.957 3.430   1.00 29.84  ?  293 TYR A O   1 
ATOM   2070 C  CB  . TYR A 1 293 ? -22.125 -25.053 5.499   1.00 28.47  ?  293 TYR A CB  1 
ATOM   2071 C  CG  . TYR A 1 293 ? -21.352 -24.180 6.453   1.00 32.79  ?  293 TYR A CG  1 
ATOM   2072 C  CD1 . TYR A 1 293 ? -21.915 -23.024 6.974   1.00 33.04  ?  293 TYR A CD1 1 
ATOM   2073 C  CD2 . TYR A 1 293 ? -20.085 -24.556 6.890   1.00 35.08  ?  293 TYR A CD2 1 
ATOM   2074 C  CE1 . TYR A 1 293 ? -21.232 -22.249 7.880   1.00 35.37  ?  293 TYR A CE1 1 
ATOM   2075 C  CE2 . TYR A 1 293 ? -19.383 -23.777 7.800   1.00 37.20  ?  293 TYR A CE2 1 
ATOM   2076 C  CZ  . TYR A 1 293 ? -19.967 -22.634 8.287   1.00 34.47  ?  293 TYR A CZ  1 
ATOM   2077 O  OH  . TYR A 1 293 ? -19.303 -21.857 9.196   1.00 41.90  ?  293 TYR A OH  1 
ATOM   2078 N  N   . ASN A 1 294 ? -20.717 -25.952 2.682   1.00 28.60  ?  294 ASN A N   1 
ATOM   2079 C  CA  . ASN A 1 294 ? -19.382 -26.414 2.325   1.00 27.17  ?  294 ASN A CA  1 
ATOM   2080 C  C   . ASN A 1 294 ? -18.780 -25.565 1.215   1.00 29.39  ?  294 ASN A C   1 
ATOM   2081 O  O   . ASN A 1 294 ? -19.473 -25.124 0.287   1.00 29.40  ?  294 ASN A O   1 
ATOM   2082 C  CB  . ASN A 1 294 ? -19.424 -27.901 1.924   1.00 29.37  ?  294 ASN A CB  1 
ATOM   2083 C  CG  . ASN A 1 294 ? -18.057 -28.481 1.682   1.00 33.04  ?  294 ASN A CG  1 
ATOM   2084 O  OD1 . ASN A 1 294 ? -17.097 -27.749 1.445   1.00 29.71  ?  294 ASN A OD1 1 
ATOM   2085 N  ND2 . ASN A 1 294 ? -17.950 -29.816 1.767   1.00 30.90  ?  294 ASN A ND2 1 
ATOM   2086 N  N   . LEU A 1 295 ? -17.475 -25.313 1.328   1.00 27.37  ?  295 LEU A N   1 
ATOM   2087 C  CA  . LEU A 1 295 ? -16.753 -24.453 0.395   1.00 28.19  ?  295 LEU A CA  1 
ATOM   2088 C  C   . LEU A 1 295 ? -15.816 -25.257 -0.505  1.00 29.35  ?  295 LEU A C   1 
ATOM   2089 O  O   . LEU A 1 295 ? -14.803 -24.737 -0.976  1.00 26.20  ?  295 LEU A O   1 
ATOM   2090 C  CB  . LEU A 1 295 ? -15.983 -23.365 1.150   1.00 25.69  ?  295 LEU A CB  1 
ATOM   2091 C  CG  . LEU A 1 295 ? -16.868 -22.448 2.017   1.00 28.55  ?  295 LEU A CG  1 
ATOM   2092 C  CD1 . LEU A 1 295 ? -16.037 -21.460 2.848   1.00 28.11  ?  295 LEU A CD1 1 
ATOM   2093 C  CD2 . LEU A 1 295 ? -17.837 -21.691 1.125   1.00 24.29  ?  295 LEU A CD2 1 
ATOM   2094 N  N   . SER A 1 296 ? -16.155 -26.527 -0.780  1.00 28.80  ?  296 SER A N   1 
ATOM   2095 C  CA  . SER A 1 296 ? -15.223 -27.359 -1.539  1.00 27.22  ?  296 SER A CA  1 
ATOM   2096 C  C   . SER A 1 296 ? -15.165 -26.943 -3.002  1.00 29.60  ?  296 SER A C   1 
ATOM   2097 O  O   . SER A 1 296 ? -14.140 -27.144 -3.668  1.00 28.31  ?  296 SER A O   1 
ATOM   2098 C  CB  . SER A 1 296 ? -15.591 -28.843 -1.417  1.00 27.05  ?  296 SER A CB  1 
ATOM   2099 O  OG  . SER A 1 296 ? -16.799 -29.126 -2.115  1.00 28.05  ?  296 SER A OG  1 
ATOM   2100 N  N   . ILE A 1 297 ? -16.233 -26.352 -3.530  1.00 27.74  ?  297 ILE A N   1 
ATOM   2101 C  CA  . ILE A 1 297 ? -16.137 -25.836 -4.891  1.00 28.27  ?  297 ILE A CA  1 
ATOM   2102 C  C   . ILE A 1 297 ? -15.232 -24.608 -4.841  1.00 28.60  ?  297 ILE A C   1 
ATOM   2103 O  O   . ILE A 1 297 ? -15.581 -23.592 -4.236  1.00 28.73  ?  297 ILE A O   1 
ATOM   2104 C  CB  . ILE A 1 297 ? -17.516 -25.508 -5.474  1.00 31.46  ?  297 ILE A CB  1 
ATOM   2105 C  CG1 . ILE A 1 297 ? -18.361 -26.784 -5.541  1.00 32.12  ?  297 ILE A CG1 1 
ATOM   2106 C  CG2 . ILE A 1 297 ? -17.380 -24.958 -6.888  1.00 29.56  ?  297 ILE A CG2 1 
ATOM   2107 C  CD1 . ILE A 1 297 ? -19.813 -26.523 -5.964  1.00 32.74  ?  297 ILE A CD1 1 
ATOM   2108 N  N   . GLY A 1 298 ? -14.047 -24.717 -5.427  1.00 27.43  ?  298 GLY A N   1 
ATOM   2109 C  CA  . GLY A 1 298 ? -13.058 -23.664 -5.371  1.00 28.15  ?  298 GLY A CA  1 
ATOM   2110 C  C   . GLY A 1 298 ? -12.965 -22.826 -6.628  1.00 31.74  ?  298 GLY A C   1 
ATOM   2111 O  O   . GLY A 1 298 ? -12.081 -21.964 -6.725  1.00 31.42  ?  298 GLY A O   1 
ATOM   2112 N  N   . ASP A 1 299 ? -13.840 -23.071 -7.605  1.00 29.28  ?  299 ASP A N   1 
ATOM   2113 C  CA  . ASP A 1 299 ? -13.951 -22.223 -8.786  1.00 30.78  ?  299 ASP A CA  1 
ATOM   2114 C  C   . ASP A 1 299 ? -15.446 -21.931 -8.884  1.00 32.87  ?  299 ASP A C   1 
ATOM   2115 O  O   . ASP A 1 299 ? -16.199 -22.245 -7.954  1.00 32.32  ?  299 ASP A O   1 
ATOM   2116 C  CB  . ASP A 1 299 ? -13.545 -22.988 -10.061 1.00 29.33  ?  299 ASP A CB  1 
ATOM   2117 C  CG  . ASP A 1 299 ? -14.470 -24.155 -10.397 1.00 32.85  ?  299 ASP A CG  1 
ATOM   2118 O  OD1 . ASP A 1 299 ? -15.194 -24.649 -9.507  1.00 30.24  ?  299 ASP A OD1 1 
ATOM   2119 O  OD2 . ASP A 1 299 ? -14.467 -24.589 -11.576 1.00 31.73  ?  299 ASP A OD2 1 
ATOM   2120 N  N   . ALA A 1 300 ? -15.891 -21.350 -9.991  1.00 30.12  ?  300 ALA A N   1 
ATOM   2121 C  CA  . ALA A 1 300 ? -17.317 -21.131 -10.218 1.00 28.89  ?  300 ALA A CA  1 
ATOM   2122 C  C   . ALA A 1 300 ? -17.894 -21.983 -11.336 1.00 31.70  ?  300 ALA A C   1 
ATOM   2123 O  O   . ALA A 1 300 ? -17.158 -22.487 -12.176 1.00 32.91  ?  300 ALA A O   1 
ATOM   2124 C  CB  . ALA A 1 300 ? -17.457 -19.637 -10.532 1.00 31.73  ?  300 ALA A CB  1 
ATOM   2125 N  N   . LEU A 1 301 ? -19.205 -22.180 -11.330 1.00 31.43  ?  301 LEU A N   1 
ATOM   2126 C  CA  . LEU A 1 301 ? -19.788 -22.997 -12.393 1.00 29.80  ?  301 LEU A CA  1 
ATOM   2127 C  C   . LEU A 1 301 ? -19.821 -22.163 -13.672 1.00 32.73  ?  301 LEU A C   1 
ATOM   2128 O  O   . LEU A 1 301 ? -20.399 -21.067 -13.673 1.00 33.20  ?  301 LEU A O   1 
ATOM   2129 C  CB  . LEU A 1 301 ? -21.183 -23.488 -12.007 1.00 29.90  ?  301 LEU A CB  1 
ATOM   2130 C  CG  . LEU A 1 301 ? -21.302 -24.217 -10.663 1.00 32.87  ?  301 LEU A CG  1 
ATOM   2131 C  CD1 . LEU A 1 301 ? -22.668 -24.868 -10.515 1.00 29.98  ?  301 LEU A CD1 1 
ATOM   2132 C  CD2 . LEU A 1 301 ? -20.199 -25.289 -10.516 1.00 26.26  ?  301 LEU A CD2 1 
ATOM   2133 N  N   . PRO A 1 302 ? -19.196 -22.611 -14.762 1.00 31.50  ?  302 PRO A N   1 
ATOM   2134 C  CA  . PRO A 1 302 ? -19.029 -21.735 -15.927 1.00 31.96  ?  302 PRO A CA  1 
ATOM   2135 C  C   . PRO A 1 302 ? -20.096 -21.936 -16.993 1.00 30.77  ?  302 PRO A C   1 
ATOM   2136 O  O   . PRO A 1 302 ? -20.573 -23.055 -17.209 1.00 32.35  ?  302 PRO A O   1 
ATOM   2137 C  CB  . PRO A 1 302 ? -17.654 -22.142 -16.450 1.00 33.46  ?  302 PRO A CB  1 
ATOM   2138 C  CG  . PRO A 1 302 ? -17.636 -23.655 -16.200 1.00 30.87  ?  302 PRO A CG  1 
ATOM   2139 C  CD  . PRO A 1 302 ? -18.425 -23.859 -14.901 1.00 33.15  ?  302 PRO A CD  1 
ATOM   2140 N  N   . ARG A 1 303 ? -20.449 -20.854 -17.684 1.00 32.53  ?  303 ARG A N   1 
ATOM   2141 C  CA  . ARG A 1 303 ? -21.402 -20.895 -18.787 1.00 35.03  ?  303 ARG A CA  1 
ATOM   2142 C  C   . ARG A 1 303 ? -20.997 -19.850 -19.818 1.00 31.60  ?  303 ARG A C   1 
ATOM   2143 O  O   . ARG A 1 303 ? -20.480 -18.789 -19.467 1.00 36.62  ?  303 ARG A O   1 
ATOM   2144 C  CB  . ARG A 1 303 ? -22.842 -20.621 -18.310 1.00 32.58  ?  303 ARG A CB  1 
ATOM   2145 C  CG  . ARG A 1 303 ? -23.353 -21.550 -17.221 1.00 32.08  ?  303 ARG A CG  1 
ATOM   2146 C  CD  . ARG A 1 303 ? -23.805 -22.868 -17.798 1.00 34.13  ?  303 ARG A CD  1 
ATOM   2147 N  NE  . ARG A 1 303 ? -24.554 -23.683 -16.847 1.00 35.96  ?  303 ARG A NE  1 
ATOM   2148 C  CZ  . ARG A 1 303 ? -23.996 -24.517 -15.977 1.00 36.60  ?  303 ARG A CZ  1 
ATOM   2149 N  NH1 . ARG A 1 303 ? -22.682 -24.593 -15.842 1.00 33.69  ?  303 ARG A NH1 1 
ATOM   2150 N  NH2 . ARG A 1 303 ? -24.773 -25.316 -15.248 1.00 30.13  ?  303 ARG A NH2 1 
ATOM   2151 N  N   . ILE A 1 304 ? -21.234 -20.154 -21.094 1.00 35.36  ?  304 ILE A N   1 
ATOM   2152 C  CA  . ILE A 1 304 ? -21.104 -19.163 -22.159 1.00 35.13  ?  304 ILE A CA  1 
ATOM   2153 C  C   . ILE A 1 304 ? -22.503 -18.727 -22.588 1.00 36.24  ?  304 ILE A C   1 
ATOM   2154 O  O   . ILE A 1 304 ? -23.366 -19.568 -22.878 1.00 37.54  ?  304 ILE A O   1 
ATOM   2155 C  CB  . ILE A 1 304 ? -20.308 -19.704 -23.359 1.00 39.32  ?  304 ILE A CB  1 
ATOM   2156 C  CG1 . ILE A 1 304 ? -18.876 -20.084 -22.949 1.00 32.21  ?  304 ILE A CG1 1 
ATOM   2157 C  CG2 . ILE A 1 304 ? -20.274 -18.652 -24.479 1.00 41.39  ?  304 ILE A CG2 1 
ATOM   2158 C  CD1 . ILE A 1 304 ? -18.009 -18.925 -22.647 1.00 34.12  ?  304 ILE A CD1 1 
ATOM   2159 N  N   . ALA A 1 305 ? -22.727 -17.418 -22.620 1.00 35.94  ?  305 ALA A N   1 
ATOM   2160 C  CA  . ALA A 1 305 ? -24.006 -16.879 -23.071 1.00 43.04  ?  305 ALA A CA  1 
ATOM   2161 C  C   . ALA A 1 305 ? -24.181 -17.135 -24.566 1.00 44.26  ?  305 ALA A C   1 
ATOM   2162 O  O   . ALA A 1 305 ? -23.360 -16.691 -25.376 1.00 49.06  ?  305 ALA A O   1 
ATOM   2163 C  CB  . ALA A 1 305 ? -24.069 -15.385 -22.766 1.00 38.63  ?  305 ALA A CB  1 
ATOM   2164 N  N   . LEU A 1 306 ? -25.242 -17.853 -24.937 1.00 43.78  ?  306 LEU A N   1 
ATOM   2165 C  CA  . LEU A 1 306 ? -25.528 -18.113 -26.345 1.00 44.25  ?  306 LEU A CA  1 
ATOM   2166 C  C   . LEU A 1 306 ? -26.324 -16.992 -27.010 1.00 48.74  ?  306 LEU A C   1 
ATOM   2167 O  O   . LEU A 1 306 ? -26.440 -16.980 -28.241 1.00 49.12  ?  306 LEU A O   1 
ATOM   2168 C  CB  . LEU A 1 306 ? -26.296 -19.431 -26.502 1.00 48.42  ?  306 LEU A CB  1 
ATOM   2169 C  CG  . LEU A 1 306 ? -25.599 -20.727 -26.077 1.00 42.66  ?  306 LEU A CG  1 
ATOM   2170 C  CD1 . LEU A 1 306 ? -26.545 -21.897 -26.253 1.00 45.93  ?  306 LEU A CD1 1 
ATOM   2171 C  CD2 . LEU A 1 306 ? -24.296 -20.950 -26.844 1.00 43.03  ?  306 LEU A CD2 1 
ATOM   2172 N  N   . ALA A 1 307 ? -26.867 -16.060 -26.228 1.00 45.63  ?  307 ALA A N   1 
ATOM   2173 C  CA  . ALA A 1 307 ? -27.615 -14.917 -26.730 1.00 51.85  ?  307 ALA A CA  1 
ATOM   2174 C  C   . ALA A 1 307 ? -27.422 -13.782 -25.736 1.00 50.10  ?  307 ALA A C   1 
ATOM   2175 O  O   . ALA A 1 307 ? -26.865 -13.977 -24.653 1.00 48.11  ?  307 ALA A O   1 
ATOM   2176 C  CB  . ALA A 1 307 ? -29.107 -15.253 -26.911 1.00 44.45  ?  307 ALA A CB  1 
ATOM   2177 N  N   . ASP A 1 308 ? -27.869 -12.585 -26.107 1.00 48.07  ?  308 ASP A N   1 
ATOM   2178 C  CA  . ASP A 1 308 ? -27.849 -11.489 -25.149 1.00 48.42  ?  308 ASP A CA  1 
ATOM   2179 C  C   . ASP A 1 308 ? -28.943 -11.722 -24.118 1.00 49.63  ?  308 ASP A C   1 
ATOM   2180 O  O   . ASP A 1 308 ? -30.068 -12.092 -24.466 1.00 49.36  ?  308 ASP A O   1 
ATOM   2181 C  CB  . ASP A 1 308 ? -28.042 -10.132 -25.831 1.00 54.02  ?  308 ASP A CB  1 
ATOM   2182 C  CG  . ASP A 1 308 ? -27.043 -9.884  -26.943 1.00 58.51  ?  308 ASP A CG  1 
ATOM   2183 O  OD1 . ASP A 1 308 ? -25.886 -10.352 -26.826 1.00 52.20  ?  308 ASP A OD1 1 
ATOM   2184 O  OD2 . ASP A 1 308 ? -27.399 -9.177  -27.913 1.00 59.38  ?  308 ASP A OD2 1 
ATOM   2185 N  N   . VAL A 1 309 ? -28.596 -11.564 -22.845 1.00 48.12  ?  309 VAL A N   1 
ATOM   2186 C  CA  . VAL A 1 309 ? -29.513 -11.790 -21.737 1.00 48.58  ?  309 VAL A CA  1 
ATOM   2187 C  C   . VAL A 1 309 ? -29.268 -10.702 -20.706 1.00 51.79  ?  309 VAL A C   1 
ATOM   2188 O  O   . VAL A 1 309 ? -28.115 -10.376 -20.396 1.00 49.20  ?  309 VAL A O   1 
ATOM   2189 C  CB  . VAL A 1 309 ? -29.322 -13.192 -21.109 1.00 48.98  ?  309 VAL A CB  1 
ATOM   2190 C  CG1 . VAL A 1 309 ? -30.302 -13.403 -19.965 1.00 49.56  ?  309 VAL A CG1 1 
ATOM   2191 C  CG2 . VAL A 1 309 ? -29.477 -14.295 -22.148 1.00 46.51  ?  309 VAL A CG2 1 
ATOM   2192 N  N   . ARG A 1 310 ? -30.351 -10.120 -20.188 1.00 43.43  ?  310 ARG A N   1 
ATOM   2193 C  CA  . ARG A 1 310 ? -30.241 -9.210  -19.060 1.00 46.86  ?  310 ARG A CA  1 
ATOM   2194 C  C   . ARG A 1 310 ? -30.370 -10.014 -17.776 1.00 46.61  ?  310 ARG A C   1 
ATOM   2195 O  O   . ARG A 1 310 ? -31.313 -10.800 -17.610 1.00 44.74  ?  310 ARG A O   1 
ATOM   2196 C  CB  . ARG A 1 310 ? -31.294 -8.100  -19.112 1.00 53.22  ?  310 ARG A CB  1 
ATOM   2197 C  CG  . ARG A 1 310 ? -30.928 -6.879  -18.269 1.00 55.49  ?  310 ARG A CG  1 
ATOM   2198 C  CD  . ARG A 1 310 ? -32.155 -6.019  -17.929 1.00 61.15  ?  310 ARG A CD  1 
ATOM   2199 N  NE  . ARG A 1 310 ? -31.841 -4.966  -16.965 1.00 68.64  ?  310 ARG A NE  1 
ATOM   2200 C  CZ  . ARG A 1 310 ? -31.125 -3.879  -17.226 1.00 64.52  ?  310 ARG A CZ  1 
ATOM   2201 N  NH1 . ARG A 1 310 ? -30.676 -3.619  -18.444 1.00 64.03  ?  310 ARG A NH1 1 
ATOM   2202 N  NH2 . ARG A 1 310 ? -30.854 -3.028  -16.240 1.00 64.50  ?  310 ARG A NH2 1 
ATOM   2203 N  N   . LEU A 1 311 ? -29.403 -9.831  -16.884 1.00 48.95  ?  311 LEU A N   1 
ATOM   2204 C  CA  . LEU A 1 311 ? -29.340 -10.550 -15.621 1.00 46.96  ?  311 LEU A CA  1 
ATOM   2205 C  C   . LEU A 1 311 ? -29.078 -9.526  -14.533 1.00 44.60  ?  311 LEU A C   1 
ATOM   2206 O  O   . LEU A 1 311 ? -28.039 -8.858  -14.544 1.00 44.43  ?  311 LEU A O   1 
ATOM   2207 C  CB  . LEU A 1 311 ? -28.239 -11.615 -15.651 1.00 44.17  ?  311 LEU A CB  1 
ATOM   2208 C  CG  . LEU A 1 311 ? -28.076 -12.458 -14.392 1.00 43.09  ?  311 LEU A CG  1 
ATOM   2209 C  CD1 . LEU A 1 311 ? -29.233 -13.453 -14.272 1.00 40.64  ?  311 LEU A CD1 1 
ATOM   2210 C  CD2 . LEU A 1 311 ? -26.714 -13.180 -14.427 1.00 37.69  ?  311 LEU A CD2 1 
ATOM   2211 N  N   . GLY A 1 312 ? -30.015 -9.400  -13.602 1.00 47.14  ?  312 GLY A N   1 
ATOM   2212 C  CA  . GLY A 1 312 ? -29.907 -8.321  -12.639 1.00 45.36  ?  312 GLY A CA  1 
ATOM   2213 C  C   . GLY A 1 312 ? -29.853 -6.994  -13.368 1.00 51.91  ?  312 GLY A C   1 
ATOM   2214 O  O   . GLY A 1 312 ? -30.673 -6.705  -14.251 1.00 51.77  ?  312 GLY A O   1 
ATOM   2215 N  N   . GLU A 1 313 ? -28.848 -6.194  -13.029 1.00 52.10  ?  313 GLU A N   1 
ATOM   2216 C  CA  . GLU A 1 313 ? -28.652 -4.872  -13.604 1.00 55.01  ?  313 GLU A CA  1 
ATOM   2217 C  C   . GLU A 1 313 ? -27.656 -4.858  -14.759 1.00 55.73  ?  313 GLU A C   1 
ATOM   2218 O  O   . GLU A 1 313 ? -27.227 -3.777  -15.172 1.00 56.93  ?  313 GLU A O   1 
ATOM   2219 C  CB  . GLU A 1 313 ? -28.187 -3.905  -12.514 1.00 57.69  ?  313 GLU A CB  1 
ATOM   2220 C  CG  . GLU A 1 313 ? -29.298 -3.431  -11.592 1.00 67.18  ?  313 GLU A CG  1 
ATOM   2221 C  CD  . GLU A 1 313 ? -28.812 -2.403  -10.586 1.00 79.87  ?  313 GLU A CD  1 
ATOM   2222 O  OE1 . GLU A 1 313 ? -27.598 -2.094  -10.591 1.00 81.76  ?  313 GLU A OE1 1 
ATOM   2223 O  OE2 . GLU A 1 313 ? -29.644 -1.901  -9.795  1.00 85.11  ?  313 GLU A OE2 1 
ATOM   2224 N  N   . VAL A 1 314 ? -27.282 -6.022  -15.292 1.00 51.06  ?  314 VAL A N   1 
ATOM   2225 C  CA  . VAL A 1 314 ? -26.187 -6.132  -16.250 1.00 47.69  ?  314 VAL A CA  1 
ATOM   2226 C  C   . VAL A 1 314 ? -26.704 -6.732  -17.551 1.00 47.89  ?  314 VAL A C   1 
ATOM   2227 O  O   . VAL A 1 314 ? -27.477 -7.699  -17.542 1.00 49.36  ?  314 VAL A O   1 
ATOM   2228 C  CB  . VAL A 1 314 ? -25.034 -6.989  -15.678 1.00 48.35  ?  314 VAL A CB  1 
ATOM   2229 C  CG1 . VAL A 1 314 ? -23.989 -7.275  -16.749 1.00 44.56  ?  314 VAL A CG1 1 
ATOM   2230 C  CG2 . VAL A 1 314 ? -24.408 -6.302  -14.463 1.00 46.14  ?  314 VAL A CG2 1 
ATOM   2231 N  N   . GLU A 1 315 ? -26.268 -6.161  -18.671 1.00 45.39  ?  315 GLU A N   1 
ATOM   2232 C  CA  . GLU A 1 315 ? -26.565 -6.708  -19.990 1.00 47.73  ?  315 GLU A CA  1 
ATOM   2233 C  C   . GLU A 1 315 ? -25.420 -7.633  -20.393 1.00 48.57  ?  315 GLU A C   1 
ATOM   2234 O  O   . GLU A 1 315 ? -24.312 -7.171  -20.681 1.00 46.18  ?  315 GLU A O   1 
ATOM   2235 C  CB  . GLU A 1 315 ? -26.746 -5.589  -21.016 1.00 52.57  ?  315 GLU A CB  1 
ATOM   2236 C  CG  . GLU A 1 315 ? -27.913 -4.651  -20.721 1.00 52.31  ?  315 GLU A CG  1 
ATOM   2237 C  CD  . GLU A 1 315 ? -29.266 -5.239  -21.092 1.00 62.47  ?  315 GLU A CD  1 
ATOM   2238 O  OE1 . GLU A 1 315 ? -29.312 -6.329  -21.707 1.00 59.77  ?  315 GLU A OE1 1 
ATOM   2239 O  OE2 . GLU A 1 315 ? -30.291 -4.607  -20.751 1.00 65.34  ?  315 GLU A OE2 1 
ATOM   2240 N  N   . ILE A 1 316 ? -25.682 -8.934  -20.419 1.00 44.82  ?  316 ILE A N   1 
ATOM   2241 C  CA  . ILE A 1 316 ? -24.669 -9.906  -20.812 1.00 47.56  ?  316 ILE A CA  1 
ATOM   2242 C  C   . ILE A 1 316 ? -24.799 -10.168 -22.309 1.00 48.79  ?  316 ILE A C   1 
ATOM   2243 O  O   . ILE A 1 316 ? -25.900 -10.435 -22.809 1.00 48.20  ?  316 ILE A O   1 
ATOM   2244 C  CB  . ILE A 1 316 ? -24.806 -11.204 -19.997 1.00 48.87  ?  316 ILE A CB  1 
ATOM   2245 C  CG1 . ILE A 1 316 ? -24.599 -10.911 -18.505 1.00 47.61  ?  316 ILE A CG1 1 
ATOM   2246 C  CG2 . ILE A 1 316 ? -23.816 -12.254 -20.494 1.00 46.20  ?  316 ILE A CG2 1 
ATOM   2247 C  CD1 . ILE A 1 316 ? -24.791 -12.117 -17.603 1.00 44.75  ?  316 ILE A CD1 1 
ATOM   2248 N  N   . ARG A 1 317 ? -23.675 -10.080 -23.024 1.00 45.65  ?  317 ARG A N   1 
ATOM   2249 C  CA  . ARG A 1 317 ? -23.640 -10.244 -24.471 1.00 47.95  ?  317 ARG A CA  1 
ATOM   2250 C  C   . ARG A 1 317 ? -23.282 -11.672 -24.855 1.00 49.44  ?  317 ARG A C   1 
ATOM   2251 O  O   . ARG A 1 317 ? -22.568 -12.370 -24.130 1.00 48.00  ?  317 ARG A O   1 
ATOM   2252 C  CB  . ARG A 1 317 ? -22.635 -9.271  -25.092 1.00 48.74  ?  317 ARG A CB  1 
ATOM   2253 C  CG  . ARG A 1 317 ? -22.805 -7.827  -24.624 1.00 51.22  ?  317 ARG A CG  1 
ATOM   2254 C  CD  . ARG A 1 317 ? -22.332 -6.842  -25.694 1.00 65.60  ?  317 ARG A CD  1 
ATOM   2255 N  NE  . ARG A 1 317 ? -21.089 -7.285  -26.320 1.00 76.40  ?  317 ARG A NE  1 
ATOM   2256 C  CZ  . ARG A 1 317 ? -20.886 -7.362  -27.630 1.00 78.39  ?  317 ARG A CZ  1 
ATOM   2257 N  NH1 . ARG A 1 317 ? -21.822 -7.008  -28.499 1.00 77.04  ?  317 ARG A NH1 1 
ATOM   2258 N  NH2 . ARG A 1 317 ? -19.714 -7.809  -28.080 1.00 75.20  ?  317 ARG A NH2 1 
ATOM   2259 N  N   . ALA A 1 318 ? -23.785 -12.107 -26.010 1.00 47.07  ?  318 ALA A N   1 
ATOM   2260 C  CA  . ALA A 1 318 ? -23.516 -13.466 -26.459 1.00 47.81  ?  318 ALA A CA  1 
ATOM   2261 C  C   . ALA A 1 318 ? -22.012 -13.700 -26.562 1.00 48.27  ?  318 ALA A C   1 
ATOM   2262 O  O   . ALA A 1 318 ? -21.258 -12.816 -26.972 1.00 43.80  ?  318 ALA A O   1 
ATOM   2263 C  CB  . ALA A 1 318 ? -24.184 -13.727 -27.809 1.00 48.55  ?  318 ALA A CB  1 
ATOM   2264 N  N   . GLY A 1 319 ? -21.573 -14.896 -26.169 1.00 46.84  ?  319 GLY A N   1 
ATOM   2265 C  CA  . GLY A 1 319 ? -20.169 -15.235 -26.207 1.00 46.54  ?  319 GLY A CA  1 
ATOM   2266 C  C   . GLY A 1 319 ? -19.383 -14.921 -24.948 1.00 47.08  ?  319 GLY A C   1 
ATOM   2267 O  O   . GLY A 1 319 ? -18.237 -15.381 -24.825 1.00 42.97  ?  319 GLY A O   1 
ATOM   2268 N  N   . GLU A 1 320 ? -19.951 -14.166 -24.009 1.00 41.10  ?  320 GLU A N   1 
ATOM   2269 C  CA  . GLU A 1 320 ? -19.228 -13.832 -22.792 1.00 41.40  ?  320 GLU A CA  1 
ATOM   2270 C  C   . GLU A 1 320 ? -19.307 -14.980 -21.786 1.00 38.63  ?  320 GLU A C   1 
ATOM   2271 O  O   . GLU A 1 320 ? -20.216 -15.812 -21.814 1.00 37.26  ?  320 GLU A O   1 
ATOM   2272 C  CB  . GLU A 1 320 ? -19.774 -12.550 -22.169 1.00 43.17  ?  320 GLU A CB  1 
ATOM   2273 C  CG  . GLU A 1 320 ? -19.612 -11.333 -23.075 1.00 46.28  ?  320 GLU A CG  1 
ATOM   2274 C  CD  . GLU A 1 320 ? -20.028 -10.043 -22.401 1.00 48.95  ?  320 GLU A CD  1 
ATOM   2275 O  OE1 . GLU A 1 320 ? -21.136 -10.003 -21.815 1.00 49.89  ?  320 GLU A OE1 1 
ATOM   2276 O  OE2 . GLU A 1 320 ? -19.256 -9.066  -22.471 1.00 47.97  ?  320 GLU A OE2 1 
ATOM   2277 N  N   . LEU A 1 321 ? -18.333 -15.006 -20.883 1.00 39.50  ?  321 LEU A N   1 
ATOM   2278 C  CA  . LEU A 1 321 ? -18.237 -16.051 -19.872 1.00 36.63  ?  321 LEU A CA  1 
ATOM   2279 C  C   . LEU A 1 321 ? -18.976 -15.619 -18.614 1.00 33.43  ?  321 LEU A C   1 
ATOM   2280 O  O   . LEU A 1 321 ? -18.795 -14.500 -18.125 1.00 37.17  ?  321 LEU A O   1 
ATOM   2281 C  CB  . LEU A 1 321 ? -16.771 -16.356 -19.560 1.00 35.40  ?  321 LEU A CB  1 
ATOM   2282 C  CG  . LEU A 1 321 ? -16.475 -17.351 -18.437 1.00 34.72  ?  321 LEU A CG  1 
ATOM   2283 C  CD1 . LEU A 1 321 ? -17.060 -18.732 -18.767 1.00 31.90  ?  321 LEU A CD1 1 
ATOM   2284 C  CD2 . LEU A 1 321 ? -14.963 -17.417 -18.234 1.00 34.98  ?  321 LEU A CD2 1 
ATOM   2285 N  N   . VAL A 1 322 ? -19.825 -16.504 -18.109 1.00 36.05  ?  322 VAL A N   1 
ATOM   2286 C  CA  . VAL A 1 322 ? -20.590 -16.263 -16.896 1.00 35.58  ?  322 VAL A CA  1 
ATOM   2287 C  C   . VAL A 1 322 ? -20.188 -17.324 -15.886 1.00 34.97  ?  322 VAL A C   1 
ATOM   2288 O  O   . VAL A 1 322 ? -20.048 -18.499 -16.243 1.00 34.62  ?  322 VAL A O   1 
ATOM   2289 C  CB  . VAL A 1 322 ? -22.108 -16.295 -17.162 1.00 38.06  ?  322 VAL A CB  1 
ATOM   2290 C  CG1 . VAL A 1 322 ? -22.894 -16.027 -15.857 1.00 34.45  ?  322 VAL A CG1 1 
ATOM   2291 C  CG2 . VAL A 1 322 ? -22.455 -15.254 -18.228 1.00 37.69  ?  322 VAL A CG2 1 
ATOM   2292 N  N   . LEU A 1 323 ? -19.978 -16.899 -14.640 1.00 33.57  ?  323 LEU A N   1 
ATOM   2293 C  CA  . LEU A 1 323 ? -19.438 -17.746 -13.582 1.00 33.00  ?  323 LEU A CA  1 
ATOM   2294 C  C   . LEU A 1 323 ? -20.373 -17.693 -12.387 1.00 31.57  ?  323 LEU A C   1 
ATOM   2295 O  O   . LEU A 1 323 ? -20.554 -16.629 -11.792 1.00 32.62  ?  323 LEU A O   1 
ATOM   2296 C  CB  . LEU A 1 323 ? -18.044 -17.269 -13.184 1.00 31.16  ?  323 LEU A CB  1 
ATOM   2297 C  CG  . LEU A 1 323 ? -16.963 -17.332 -14.259 1.00 32.11  ?  323 LEU A CG  1 
ATOM   2298 C  CD1 . LEU A 1 323 ? -15.737 -16.629 -13.725 1.00 31.23  ?  323 LEU A CD1 1 
ATOM   2299 C  CD2 . LEU A 1 323 ? -16.658 -18.781 -14.611 1.00 31.54  ?  323 LEU A CD2 1 
ATOM   2300 N  N   . VAL A 1 324 ? -20.948 -18.834 -12.027 1.00 33.33  ?  324 VAL A N   1 
ATOM   2301 C  CA  . VAL A 1 324 ? -21.899 -18.901 -10.924 1.00 30.50  ?  324 VAL A CA  1 
ATOM   2302 C  C   . VAL A 1 324 ? -21.127 -19.208 -9.648  1.00 34.39  ?  324 VAL A C   1 
ATOM   2303 O  O   . VAL A 1 324 ? -20.556 -20.295 -9.518  1.00 30.58  ?  324 VAL A O   1 
ATOM   2304 C  CB  . VAL A 1 324 ? -22.973 -19.968 -11.182 1.00 34.15  ?  324 VAL A CB  1 
ATOM   2305 C  CG1 . VAL A 1 324 ? -23.942 -20.035 -10.017 1.00 32.82  ?  324 VAL A CG1 1 
ATOM   2306 C  CG2 . VAL A 1 324 ? -23.716 -19.682 -12.483 1.00 34.34  ?  324 VAL A CG2 1 
ATOM   2307 N  N   . LEU A 1 325 ? -21.138 -18.269 -8.695  1.00 32.70  ?  325 LEU A N   1 
ATOM   2308 C  CA  . LEU A 1 325 ? -20.415 -18.424 -7.430  1.00 33.55  ?  325 LEU A CA  1 
ATOM   2309 C  C   . LEU A 1 325 ? -21.317 -19.121 -6.418  1.00 34.42  ?  325 LEU A C   1 
ATOM   2310 O  O   . LEU A 1 325 ? -22.162 -18.487 -5.786  1.00 33.85  ?  325 LEU A O   1 
ATOM   2311 C  CB  . LEU A 1 325 ? -19.952 -17.072 -6.905  1.00 34.32  ?  325 LEU A CB  1 
ATOM   2312 C  CG  . LEU A 1 325 ? -19.001 -17.192 -5.708  1.00 38.60  ?  325 LEU A CG  1 
ATOM   2313 C  CD1 . LEU A 1 325 ? -17.622 -17.670 -6.165  1.00 32.79  ?  325 LEU A CD1 1 
ATOM   2314 C  CD2 . LEU A 1 325 ? -18.889 -15.880 -4.951  1.00 33.51  ?  325 LEU A CD2 1 
ATOM   2315 N  N   . ILE A 1 326 ? -21.099 -20.426 -6.220  1.00 32.22  ?  326 ILE A N   1 
ATOM   2316 C  CA  . ILE A 1 326 ? -22.037 -21.227 -5.438  1.00 33.88  ?  326 ILE A CA  1 
ATOM   2317 C  C   . ILE A 1 326 ? -22.034 -20.801 -3.977  1.00 34.57  ?  326 ILE A C   1 
ATOM   2318 O  O   . ILE A 1 326 ? -23.087 -20.757 -3.331  1.00 31.26  ?  326 ILE A O   1 
ATOM   2319 C  CB  . ILE A 1 326 ? -21.718 -22.721 -5.600  1.00 31.95  ?  326 ILE A CB  1 
ATOM   2320 C  CG1 . ILE A 1 326 ? -21.989 -23.164 -7.041  1.00 32.91  ?  326 ILE A CG1 1 
ATOM   2321 C  CG2 . ILE A 1 326 ? -22.540 -23.576 -4.625  1.00 33.60  ?  326 ILE A CG2 1 
ATOM   2322 C  CD1 . ILE A 1 326 ? -23.470 -23.098 -7.457  1.00 34.56  ?  326 ILE A CD1 1 
ATOM   2323 N  N   . GLU A 1 327 ? -20.865 -20.457 -3.432  1.00 30.27  ?  327 GLU A N   1 
ATOM   2324 C  CA  . GLU A 1 327 ? -20.818 -20.064 -2.029  1.00 33.26  ?  327 GLU A CA  1 
ATOM   2325 C  C   . GLU A 1 327 ? -21.464 -18.708 -1.810  1.00 32.43  ?  327 GLU A C   1 
ATOM   2326 O  O   . GLU A 1 327 ? -21.961 -18.439 -0.717  1.00 31.44  ?  327 GLU A O   1 
ATOM   2327 C  CB  . GLU A 1 327 ? -19.373 -20.020 -1.531  1.00 32.12  ?  327 GLU A CB  1 
ATOM   2328 C  CG  . GLU A 1 327 ? -18.507 -19.084 -2.354  1.00 32.96  ?  327 GLU A CG  1 
ATOM   2329 C  CD  . GLU A 1 327 ? -17.529 -19.865 -3.193  1.00 42.86  ?  327 GLU A CD  1 
ATOM   2330 O  OE1 . GLU A 1 327 ? -18.012 -20.648 -4.071  1.00 44.42  ?  327 GLU A OE1 1 
ATOM   2331 O  OE2 . GLU A 1 327 ? -16.311 -19.725 -2.967  1.00 40.07  ?  327 GLU A OE2 1 
ATOM   2332 N  N   . GLY A 1 328 ? -21.420 -17.822 -2.810  1.00 33.02  ?  328 GLY A N   1 
ATOM   2333 C  CA  . GLY A 1 328 ? -22.183 -16.587 -2.699  1.00 31.05  ?  328 GLY A CA  1 
ATOM   2334 C  C   . GLY A 1 328 ? -23.674 -16.855 -2.595  1.00 33.42  ?  328 GLY A C   1 
ATOM   2335 O  O   . GLY A 1 328 ? -24.365 -16.291 -1.745  1.00 33.27  ?  328 GLY A O   1 
ATOM   2336 N  N   . ALA A 1 329 ? -24.183 -17.748 -3.444  1.00 34.40  ?  329 ALA A N   1 
ATOM   2337 C  CA  . ALA A 1 329 ? -25.603 -18.077 -3.405  1.00 31.65  ?  329 ALA A CA  1 
ATOM   2338 C  C   . ALA A 1 329 ? -25.975 -18.797 -2.107  1.00 32.70  ?  329 ALA A C   1 
ATOM   2339 O  O   . ALA A 1 329 ? -27.004 -18.499 -1.490  1.00 31.30  ?  329 ALA A O   1 
ATOM   2340 C  CB  . ALA A 1 329 ? -25.960 -18.931 -4.629  1.00 32.13  ?  329 ALA A CB  1 
ATOM   2341 N  N   . ASN A 1 330 ? -25.159 -19.764 -1.679  1.00 31.29  ?  330 ASN A N   1 
ATOM   2342 C  CA  . ASN A 1 330 ? -25.531 -20.591 -0.535  1.00 29.33  ?  330 ASN A CA  1 
ATOM   2343 C  C   . ASN A 1 330 ? -25.397 -19.870 0.798   1.00 31.27  ?  330 ASN A C   1 
ATOM   2344 O  O   . ASN A 1 330 ? -25.888 -20.383 1.816   1.00 30.46  ?  330 ASN A O   1 
ATOM   2345 C  CB  . ASN A 1 330 ? -24.684 -21.863 -0.544  1.00 29.32  ?  330 ASN A CB  1 
ATOM   2346 C  CG  . ASN A 1 330 ? -25.239 -22.904 -1.502  1.00 33.40  ?  330 ASN A CG  1 
ATOM   2347 O  OD1 . ASN A 1 330 ? -26.361 -22.762 -2.004  1.00 33.45  ?  330 ASN A OD1 1 
ATOM   2348 N  ND2 . ASN A 1 330 ? -24.468 -23.951 -1.762  1.00 29.68  ?  330 ASN A ND2 1 
ATOM   2349 N  N   . TYR A 1 331 ? -24.735 -18.713 0.818   1.00 25.94  ?  331 TYR A N   1 
ATOM   2350 C  CA  . TYR A 1 331 ? -24.620 -17.876 2.005   1.00 30.87  ?  331 TYR A CA  1 
ATOM   2351 C  C   . TYR A 1 331 ? -25.424 -16.584 1.867   1.00 33.92  ?  331 TYR A C   1 
ATOM   2352 O  O   . TYR A 1 331 ? -25.178 -15.621 2.600   1.00 31.20  ?  331 TYR A O   1 
ATOM   2353 C  CB  . TYR A 1 331 ? -23.155 -17.544 2.290   1.00 30.50  ?  331 TYR A CB  1 
ATOM   2354 C  CG  . TYR A 1 331 ? -22.342 -18.665 2.929   1.00 29.79  ?  331 TYR A CG  1 
ATOM   2355 C  CD1 . TYR A 1 331 ? -21.972 -19.786 2.194   1.00 29.31  ?  331 TYR A CD1 1 
ATOM   2356 C  CD2 . TYR A 1 331 ? -21.923 -18.580 4.247   1.00 29.25  ?  331 TYR A CD2 1 
ATOM   2357 C  CE1 . TYR A 1 331 ? -21.218 -20.813 2.772   1.00 29.47  ?  331 TYR A CE1 1 
ATOM   2358 C  CE2 . TYR A 1 331 ? -21.155 -19.595 4.828   1.00 31.52  ?  331 TYR A CE2 1 
ATOM   2359 C  CZ  . TYR A 1 331 ? -20.806 -20.706 4.081   1.00 31.24  ?  331 TYR A CZ  1 
ATOM   2360 O  OH  . TYR A 1 331 ? -20.032 -21.717 4.638   1.00 27.60  ?  331 TYR A OH  1 
ATOM   2361 N  N   . ASP A 1 332 ? -26.363 -16.547 0.940   1.00 31.02  ?  332 ASP A N   1 
ATOM   2362 C  CA  . ASP A 1 332 ? -27.176 -15.350 0.699   1.00 32.79  ?  332 ASP A CA  1 
ATOM   2363 C  C   . ASP A 1 332 ? -28.215 -15.186 1.803   1.00 31.03  ?  332 ASP A C   1 
ATOM   2364 O  O   . ASP A 1 332 ? -29.159 -15.991 1.877   1.00 31.95  ?  332 ASP A O   1 
ATOM   2365 C  CB  . ASP A 1 332 ? -27.842 -15.466 -0.678  1.00 32.37  ?  332 ASP A CB  1 
ATOM   2366 C  CG  . ASP A 1 332 ? -28.455 -14.145 -1.159  1.00 38.42  ?  332 ASP A CG  1 
ATOM   2367 O  OD1 . ASP A 1 332 ? -28.807 -13.316 -0.305  1.00 37.43  ?  332 ASP A OD1 1 
ATOM   2368 O  OD2 . ASP A 1 332 ? -28.564 -13.947 -2.389  1.00 33.88  ?  332 ASP A OD2 1 
ATOM   2369 N  N   . PRO A 1 333 ? -28.110 -14.162 2.654   1.00 35.38  ?  333 PRO A N   1 
ATOM   2370 C  CA  . PRO A 1 333 ? -29.058 -14.031 3.773   1.00 35.10  ?  333 PRO A CA  1 
ATOM   2371 C  C   . PRO A 1 333 ? -30.474 -13.689 3.340   1.00 36.66  ?  333 PRO A C   1 
ATOM   2372 O  O   . PRO A 1 333 ? -31.387 -13.772 4.171   1.00 39.91  ?  333 PRO A O   1 
ATOM   2373 C  CB  . PRO A 1 333 ? -28.455 -12.902 4.620   1.00 36.81  ?  333 PRO A CB  1 
ATOM   2374 C  CG  . PRO A 1 333 ? -27.651 -12.083 3.645   1.00 38.28  ?  333 PRO A CG  1 
ATOM   2375 C  CD  . PRO A 1 333 ? -27.141 -13.053 2.600   1.00 37.67  ?  333 PRO A CD  1 
ATOM   2376 N  N   . ALA A 1 334 ? -30.691 -13.302 2.084   1.00 38.76  ?  334 ALA A N   1 
ATOM   2377 C  CA  . ALA A 1 334 ? -32.061 -13.145 1.611   1.00 39.14  ?  334 ALA A CA  1 
ATOM   2378 C  C   . ALA A 1 334 ? -32.780 -14.482 1.532   1.00 39.52  ?  334 ALA A C   1 
ATOM   2379 O  O   . ALA A 1 334 ? -34.017 -14.521 1.567   1.00 39.24  ?  334 ALA A O   1 
ATOM   2380 C  CB  . ALA A 1 334 ? -32.072 -12.470 0.242   1.00 41.48  ?  334 ALA A CB  1 
ATOM   2381 N  N   . VAL A 1 335 ? -32.033 -15.585 1.439   1.00 37.53  ?  335 VAL A N   1 
ATOM   2382 C  CA  . VAL A 1 335 ? -32.603 -16.919 1.345   1.00 31.79  ?  335 VAL A CA  1 
ATOM   2383 C  C   . VAL A 1 335 ? -32.271 -17.766 2.559   1.00 37.07  ?  335 VAL A C   1 
ATOM   2384 O  O   . VAL A 1 335 ? -33.094 -18.566 3.007   1.00 37.20  ?  335 VAL A O   1 
ATOM   2385 C  CB  . VAL A 1 335 ? -32.126 -17.607 0.050   1.00 36.16  ?  335 VAL A CB  1 
ATOM   2386 C  CG1 . VAL A 1 335 ? -32.605 -19.048 -0.030  1.00 36.80  ?  335 VAL A CG1 1 
ATOM   2387 C  CG2 . VAL A 1 335 ? -32.599 -16.798 -1.166  1.00 38.44  ?  335 VAL A CG2 1 
ATOM   2388 N  N   . PHE A 1 336 ? -31.080 -17.600 3.129   1.00 34.41  ?  336 PHE A N   1 
ATOM   2389 C  CA  . PHE A 1 336 ? -30.682 -18.403 4.285   1.00 34.96  ?  336 PHE A CA  1 
ATOM   2390 C  C   . PHE A 1 336 ? -30.370 -17.500 5.466   1.00 35.97  ?  336 PHE A C   1 
ATOM   2391 O  O   . PHE A 1 336 ? -29.292 -16.883 5.508   1.00 35.63  ?  336 PHE A O   1 
ATOM   2392 C  CB  . PHE A 1 336 ? -29.481 -19.291 3.959   1.00 32.46  ?  336 PHE A CB  1 
ATOM   2393 C  CG  . PHE A 1 336 ? -29.646 -20.107 2.703   1.00 31.72  ?  336 PHE A CG  1 
ATOM   2394 C  CD1 . PHE A 1 336 ? -30.257 -21.346 2.747   1.00 30.17  ?  336 PHE A CD1 1 
ATOM   2395 C  CD2 . PHE A 1 336 ? -29.190 -19.631 1.487   1.00 31.86  ?  336 PHE A CD2 1 
ATOM   2396 C  CE1 . PHE A 1 336 ? -30.414 -22.099 1.594   1.00 30.90  ?  336 PHE A CE1 1 
ATOM   2397 C  CE2 . PHE A 1 336 ? -29.334 -20.380 0.333   1.00 32.15  ?  336 PHE A CE2 1 
ATOM   2398 C  CZ  . PHE A 1 336 ? -29.947 -21.610 0.390   1.00 31.07  ?  336 PHE A CZ  1 
ATOM   2399 N  N   . PRO A 1 337 ? -31.266 -17.384 6.444   1.00 35.82  ?  337 PRO A N   1 
ATOM   2400 C  CA  . PRO A 1 337 ? -30.948 -16.581 7.630   1.00 37.87  ?  337 PRO A CA  1 
ATOM   2401 C  C   . PRO A 1 337 ? -29.726 -17.150 8.335   1.00 37.23  ?  337 PRO A C   1 
ATOM   2402 O  O   . PRO A 1 337 ? -29.432 -18.341 8.228   1.00 35.60  ?  337 PRO A O   1 
ATOM   2403 C  CB  . PRO A 1 337 ? -32.206 -16.704 8.492   1.00 36.70  ?  337 PRO A CB  1 
ATOM   2404 C  CG  . PRO A 1 337 ? -32.897 -17.918 8.002   1.00 42.75  ?  337 PRO A CG  1 
ATOM   2405 C  CD  . PRO A 1 337 ? -32.576 -18.050 6.549   1.00 36.93  ?  337 PRO A CD  1 
ATOM   2406 N  N   . HIS A 1 338 ? -29.026 -16.276 9.073   1.00 35.88  ?  338 HIS A N   1 
ATOM   2407 C  CA  . HIS A 1 338 ? -27.730 -16.543 9.697   1.00 36.77  ?  338 HIS A CA  1 
ATOM   2408 C  C   . HIS A 1 338 ? -26.925 -17.528 8.859   1.00 30.31  ?  338 HIS A C   1 
ATOM   2409 O  O   . HIS A 1 338 ? -26.606 -18.630 9.326   1.00 32.65  ?  338 HIS A O   1 
ATOM   2410 C  CB  . HIS A 1 338 ? -27.894 -17.057 11.132  1.00 33.85  ?  338 HIS A CB  1 
ATOM   2411 C  CG  . HIS A 1 338 ? -28.900 -18.167 11.289  1.00 36.19  ?  338 HIS A CG  1 
ATOM   2412 N  ND1 . HIS A 1 338 ? -30.254 -17.933 11.425  1.00 36.21  ?  338 HIS A ND1 1 
ATOM   2413 C  CD2 . HIS A 1 338 ? -28.743 -19.511 11.376  1.00 34.32  ?  338 HIS A CD2 1 
ATOM   2414 C  CE1 . HIS A 1 338 ? -30.892 -19.083 11.570  1.00 35.21  ?  338 HIS A CE1 1 
ATOM   2415 N  NE2 . HIS A 1 338 ? -29.999 -20.059 11.540  1.00 36.18  ?  338 HIS A NE2 1 
ATOM   2416 N  N   . PRO A 1 339 ? -26.583 -17.175 7.615   1.00 34.20  ?  339 PRO A N   1 
ATOM   2417 C  CA  . PRO A 1 339 ? -25.959 -18.167 6.716   1.00 34.03  ?  339 PRO A CA  1 
ATOM   2418 C  C   . PRO A 1 339 ? -24.597 -18.633 7.188   1.00 33.89  ?  339 PRO A C   1 
ATOM   2419 O  O   . PRO A 1 339 ? -24.157 -19.730 6.810   1.00 32.11  ?  339 PRO A O   1 
ATOM   2420 C  CB  . PRO A 1 339 ? -25.852 -17.415 5.383   1.00 32.53  ?  339 PRO A CB  1 
ATOM   2421 C  CG  . PRO A 1 339 ? -25.816 -15.938 5.794   1.00 33.59  ?  339 PRO A CG  1 
ATOM   2422 C  CD  . PRO A 1 339 ? -26.683 -15.838 6.995   1.00 34.49  ?  339 PRO A CD  1 
ATOM   2423 N  N   . GLU A 1 340 ? -23.925 -17.843 8.014   1.00 32.20  ?  340 GLU A N   1 
ATOM   2424 C  CA  . GLU A 1 340 ? -22.595 -18.167 8.514   1.00 34.96  ?  340 GLU A CA  1 
ATOM   2425 C  C   . GLU A 1 340 ? -22.627 -19.163 9.660   1.00 35.35  ?  340 GLU A C   1 
ATOM   2426 O  O   . GLU A 1 340 ? -21.562 -19.579 10.119  1.00 31.65  ?  340 GLU A O   1 
ATOM   2427 C  CB  . GLU A 1 340 ? -21.889 -16.874 8.955   1.00 34.99  ?  340 GLU A CB  1 
ATOM   2428 C  CG  . GLU A 1 340 ? -22.254 -16.410 10.367  1.00 37.01  ?  340 GLU A CG  1 
ATOM   2429 C  CD  . GLU A 1 340 ? -23.590 -15.659 10.441  1.00 41.30  ?  340 GLU A CD  1 
ATOM   2430 O  OE1 . GLU A 1 340 ? -24.265 -15.501 9.394   1.00 37.46  ?  340 GLU A OE1 1 
ATOM   2431 O  OE2 . GLU A 1 340 ? -23.965 -15.226 11.558  1.00 41.16  ?  340 GLU A OE2 1 
ATOM   2432 N  N   . ARG A 1 341 ? -23.815 -19.566 10.114  1.00 33.55  ?  341 ARG A N   1 
ATOM   2433 C  CA  . ARG A 1 341 ? -23.977 -20.482 11.238  1.00 32.75  ?  341 ARG A CA  1 
ATOM   2434 C  C   . ARG A 1 341 ? -24.593 -21.781 10.731  1.00 34.55  ?  341 ARG A C   1 
ATOM   2435 O  O   . ARG A 1 341 ? -25.678 -21.769 10.136  1.00 30.35  ?  341 ARG A O   1 
ATOM   2436 C  CB  . ARG A 1 341 ? -24.853 -19.860 12.335  1.00 34.48  ?  341 ARG A CB  1 
ATOM   2437 C  CG  . ARG A 1 341 ? -24.286 -18.551 12.945  1.00 38.57  ?  341 ARG A CG  1 
ATOM   2438 C  CD  . ARG A 1 341 ? -25.169 -18.023 14.097  1.00 34.90  ?  341 ARG A CD  1 
ATOM   2439 N  NE  . ARG A 1 341 ? -24.979 -18.800 15.319  1.00 34.27  ?  341 ARG A NE  1 
ATOM   2440 C  CZ  . ARG A 1 341 ? -23.913 -18.696 16.099  1.00 40.80  ?  341 ARG A CZ  1 
ATOM   2441 N  NH1 . ARG A 1 341 ? -22.943 -17.835 15.828  1.00 42.00  ?  341 ARG A NH1 1 
ATOM   2442 N  NH2 . ARG A 1 341 ? -23.814 -19.478 17.173  1.00 35.41  ?  341 ARG A NH2 1 
ATOM   2443 N  N   . ILE A 1 342 ? -23.894 -22.897 10.959  1.00 30.59  ?  342 ILE A N   1 
ATOM   2444 C  CA  . ILE A 1 342 ? -24.451 -24.201 10.628  1.00 29.10  ?  342 ILE A CA  1 
ATOM   2445 C  C   . ILE A 1 342 ? -25.685 -24.447 11.480  1.00 32.23  ?  342 ILE A C   1 
ATOM   2446 O  O   . ILE A 1 342 ? -25.681 -24.231 12.701  1.00 28.66  ?  342 ILE A O   1 
ATOM   2447 C  CB  . ILE A 1 342 ? -23.404 -25.302 10.835  1.00 31.23  ?  342 ILE A CB  1 
ATOM   2448 C  CG1 . ILE A 1 342 ? -22.317 -25.202 9.760   1.00 30.79  ?  342 ILE A CG1 1 
ATOM   2449 C  CG2 . ILE A 1 342 ? -24.078 -26.690 10.753  1.00 30.10  ?  342 ILE A CG2 1 
ATOM   2450 C  CD1 . ILE A 1 342 ? -21.066 -26.026 10.085  1.00 29.63  ?  342 ILE A CD1 1 
ATOM   2451 N  N   . ASP A 1 343 ? -26.743 -24.926 10.835  1.00 30.83  ?  343 ASP A N   1 
ATOM   2452 C  CA  . ASP A 1 343 ? -28.048 -25.061 11.468  1.00 31.86  ?  343 ASP A CA  1 
ATOM   2453 C  C   . ASP A 1 343 ? -28.723 -26.271 10.836  1.00 30.35  ?  343 ASP A C   1 
ATOM   2454 O  O   . ASP A 1 343 ? -29.151 -26.204 9.686   1.00 29.84  ?  343 ASP A O   1 
ATOM   2455 C  CB  . ASP A 1 343 ? -28.857 -23.775 11.254  1.00 30.40  ?  343 ASP A CB  1 
ATOM   2456 C  CG  . ASP A 1 343 ? -30.201 -23.795 11.963  1.00 34.92  ?  343 ASP A CG  1 
ATOM   2457 O  OD1 . ASP A 1 343 ? -30.631 -24.860 12.460  1.00 30.95  ?  343 ASP A OD1 1 
ATOM   2458 O  OD2 . ASP A 1 343 ? -30.839 -22.720 11.998  1.00 32.88  ?  343 ASP A OD2 1 
ATOM   2459 N  N   . PHE A 1 344 ? -28.789 -27.372 11.573  1.00 31.16  ?  344 PHE A N   1 
ATOM   2460 C  CA  . PHE A 1 344 ? -29.393 -28.601 11.074  1.00 30.32  ?  344 PHE A CA  1 
ATOM   2461 C  C   . PHE A 1 344 ? -30.919 -28.543 11.072  1.00 37.10  ?  344 PHE A C   1 
ATOM   2462 O  O   . PHE A 1 344 ? -31.566 -29.512 10.648  1.00 36.73  ?  344 PHE A O   1 
ATOM   2463 C  CB  . PHE A 1 344 ? -28.931 -29.799 11.924  1.00 32.87  ?  344 PHE A CB  1 
ATOM   2464 C  CG  . PHE A 1 344 ? -27.471 -30.180 11.752  1.00 32.05  ?  344 PHE A CG  1 
ATOM   2465 C  CD1 . PHE A 1 344 ? -26.700 -29.649 10.736  1.00 30.61  ?  344 PHE A CD1 1 
ATOM   2466 C  CD2 . PHE A 1 344 ? -26.879 -31.076 12.634  1.00 32.10  ?  344 PHE A CD2 1 
ATOM   2467 C  CE1 . PHE A 1 344 ? -25.359 -30.013 10.597  1.00 30.68  ?  344 PHE A CE1 1 
ATOM   2468 C  CE2 . PHE A 1 344 ? -25.553 -31.458 12.492  1.00 32.66  ?  344 PHE A CE2 1 
ATOM   2469 C  CZ  . PHE A 1 344 ? -24.791 -30.920 11.474  1.00 30.92  ?  344 PHE A CZ  1 
ATOM   2470 N  N   . ASP A 1 345 ? -31.513 -27.444 11.537  1.00 33.24  ?  345 ASP A N   1 
ATOM   2471 C  CA  . ASP A 1 345 ? -32.958 -27.361 11.721  1.00 33.46  ?  345 ASP A CA  1 
ATOM   2472 C  C   . ASP A 1 345 ? -33.573 -26.200 10.953  1.00 36.30  ?  345 ASP A C   1 
ATOM   2473 O  O   . ASP A 1 345 ? -34.550 -25.585 11.401  1.00 34.02  ?  345 ASP A O   1 
ATOM   2474 C  CB  . ASP A 1 345 ? -33.302 -27.264 13.207  1.00 34.77  ?  345 ASP A CB  1 
ATOM   2475 C  CG  . ASP A 1 345 ? -32.809 -28.465 13.984  1.00 34.97  ?  345 ASP A CG  1 
ATOM   2476 O  OD1 . ASP A 1 345 ? -33.439 -29.525 13.859  1.00 34.34  ?  345 ASP A OD1 1 
ATOM   2477 O  OD2 . ASP A 1 345 ? -31.798 -28.370 14.720  1.00 32.62  ?  345 ASP A OD2 1 
ATOM   2478 N  N   . ARG A 1 346 ? -33.024 -25.890 9.780   1.00 34.12  ?  346 ARG A N   1 
ATOM   2479 C  CA  . ARG A 1 346 ? -33.604 -24.837 8.954   1.00 36.88  ?  346 ARG A CA  1 
ATOM   2480 C  C   . ARG A 1 346 ? -34.956 -25.281 8.405   1.00 42.15  ?  346 ARG A C   1 
ATOM   2481 O  O   . ARG A 1 346 ? -35.134 -26.433 8.003   1.00 39.87  ?  346 ARG A O   1 
ATOM   2482 C  CB  . ARG A 1 346 ? -32.662 -24.474 7.805   1.00 35.60  ?  346 ARG A CB  1 
ATOM   2483 C  CG  . ARG A 1 346 ? -31.369 -23.826 8.283   1.00 31.03  ?  346 ARG A CG  1 
ATOM   2484 C  CD  . ARG A 1 346 ? -30.346 -23.633 7.165   1.00 32.75  ?  346 ARG A CD  1 
ATOM   2485 N  NE  . ARG A 1 346 ? -29.183 -22.920 7.689   1.00 31.33  ?  346 ARG A NE  1 
ATOM   2486 C  CZ  . ARG A 1 346 ? -29.131 -21.607 7.881   1.00 34.96  ?  346 ARG A CZ  1 
ATOM   2487 N  NH1 . ARG A 1 346 ? -30.134 -20.813 7.526   1.00 32.75  ?  346 ARG A NH1 1 
ATOM   2488 N  NH2 . ARG A 1 346 ? -28.047 -21.071 8.439   1.00 31.14  ?  346 ARG A NH2 1 
ATOM   2489 N  N   . GLU A 1 347 ? -35.920 -24.359 8.403   1.00 40.78  ?  347 GLU A N   1 
ATOM   2490 C  CA  . GLU A 1 347 ? -37.232 -24.685 7.852   1.00 44.30  ?  347 GLU A CA  1 
ATOM   2491 C  C   . GLU A 1 347 ? -37.125 -25.038 6.379   1.00 42.64  ?  347 GLU A C   1 
ATOM   2492 O  O   . GLU A 1 347 ? -37.806 -25.949 5.897   1.00 43.43  ?  347 GLU A O   1 
ATOM   2493 C  CB  . GLU A 1 347 ? -38.191 -23.509 8.039   1.00 49.62  ?  347 GLU A CB  1 
ATOM   2494 C  CG  . GLU A 1 347 ? -39.592 -23.905 8.486   1.00 59.58  ?  347 GLU A CG  1 
ATOM   2495 C  CD  . GLU A 1 347 ? -40.370 -22.722 9.043   1.00 67.25  ?  347 GLU A CD  1 
ATOM   2496 O  OE1 . GLU A 1 347 ? -40.818 -21.887 8.225   1.00 70.06  ?  347 GLU A OE1 1 
ATOM   2497 O  OE2 . GLU A 1 347 ? -40.535 -22.624 10.286  1.00 69.81  ?  347 GLU A OE2 1 
ATOM   2498 N  N   . SER A 1 348 ? -36.246 -24.348 5.658   1.00 40.46  ?  348 SER A N   1 
ATOM   2499 C  CA  . SER A 1 348 ? -36.131 -24.472 4.212   1.00 44.96  ?  348 SER A CA  1 
ATOM   2500 C  C   . SER A 1 348 ? -34.652 -24.391 3.854   1.00 43.09  ?  348 SER A C   1 
ATOM   2501 O  O   . SER A 1 348 ? -33.942 -23.520 4.366   1.00 41.57  ?  348 SER A O   1 
ATOM   2502 C  CB  . SER A 1 348 ? -36.942 -23.358 3.524   1.00 45.28  ?  348 SER A CB  1 
ATOM   2503 O  OG  . SER A 1 348 ? -36.537 -23.141 2.193   1.00 53.63  ?  348 SER A OG  1 
ATOM   2504 N  N   . ASN A 1 349 ? -34.182 -25.292 2.991   1.00 41.43  ?  349 ASN A N   1 
ATOM   2505 C  CA  . ASN A 1 349 ? -32.770 -25.318 2.595   1.00 41.36  ?  349 ASN A CA  1 
ATOM   2506 C  C   . ASN A 1 349 ? -32.626 -25.621 1.109   1.00 38.09  ?  349 ASN A C   1 
ATOM   2507 O  O   . ASN A 1 349 ? -32.119 -26.682 0.720   1.00 36.76  ?  349 ASN A O   1 
ATOM   2508 C  CB  . ASN A 1 349 ? -31.995 -26.337 3.430   1.00 36.48  ?  349 ASN A CB  1 
ATOM   2509 C  CG  . ASN A 1 349 ? -30.520 -25.982 3.532   1.00 36.62  ?  349 ASN A CG  1 
ATOM   2510 O  OD1 . ASN A 1 349 ? -30.022 -25.142 2.781   1.00 37.59  ?  349 ASN A OD1 1 
ATOM   2511 N  ND2 . ASN A 1 349 ? -29.825 -26.602 4.467   1.00 36.73  ?  349 ASN A ND2 1 
ATOM   2512 N  N   . PRO A 1 350 ? -33.032 -24.683 0.242   1.00 37.15  ?  350 PRO A N   1 
ATOM   2513 C  CA  . PRO A 1 350 ? -32.958 -24.907 -1.210  1.00 36.72  ?  350 PRO A CA  1 
ATOM   2514 C  C   . PRO A 1 350 ? -31.588 -24.542 -1.786  1.00 35.37  ?  350 PRO A C   1 
ATOM   2515 O  O   . PRO A 1 350 ? -31.471 -23.747 -2.725  1.00 33.09  ?  350 PRO A O   1 
ATOM   2516 C  CB  . PRO A 1 350 ? -34.078 -23.997 -1.730  1.00 43.00  ?  350 PRO A CB  1 
ATOM   2517 C  CG  . PRO A 1 350 ? -34.064 -22.816 -0.760  1.00 37.24  ?  350 PRO A CG  1 
ATOM   2518 C  CD  . PRO A 1 350 ? -33.593 -23.356 0.573   1.00 35.58  ?  350 PRO A CD  1 
ATOM   2519 N  N   . HIS A 1 351 ? -30.534 -25.155 -1.240  1.00 34.02  ?  351 HIS A N   1 
ATOM   2520 C  CA  . HIS A 1 351 ? -29.176 -24.750 -1.585  1.00 32.98  ?  351 HIS A CA  1 
ATOM   2521 C  C   . HIS A 1 351 ? -28.809 -25.222 -2.991  1.00 35.24  ?  351 HIS A C   1 
ATOM   2522 O  O   . HIS A 1 351 ? -29.447 -26.110 -3.566  1.00 31.78  ?  351 HIS A O   1 
ATOM   2523 C  CB  . HIS A 1 351 ? -28.173 -25.312 -0.571  1.00 29.21  ?  351 HIS A CB  1 
ATOM   2524 C  CG  . HIS A 1 351 ? -28.144 -26.806 -0.527  1.00 31.87  ?  351 HIS A CG  1 
ATOM   2525 N  ND1 . HIS A 1 351 ? -27.550 -27.567 -1.511  1.00 33.72  ?  351 HIS A ND1 1 
ATOM   2526 C  CD2 . HIS A 1 351 ? -28.680 -27.684 0.356   1.00 33.13  ?  351 HIS A CD2 1 
ATOM   2527 C  CE1 . HIS A 1 351 ? -27.699 -28.850 -1.226  1.00 34.61  ?  351 HIS A CE1 1 
ATOM   2528 N  NE2 . HIS A 1 351 ? -28.381 -28.950 -0.098  1.00 33.68  ?  351 HIS A NE2 1 
ATOM   2529 N  N   . LEU A 1 352 ? -27.736 -24.629 -3.528  1.00 32.82  ?  352 LEU A N   1 
ATOM   2530 C  CA  . LEU A 1 352 ? -27.229 -24.917 -4.867  1.00 32.09  ?  352 LEU A CA  1 
ATOM   2531 C  C   . LEU A 1 352 ? -25.940 -25.748 -4.845  1.00 31.36  ?  352 LEU A C   1 
ATOM   2532 O  O   . LEU A 1 352 ? -25.144 -25.676 -5.779  1.00 32.44  ?  352 LEU A O   1 
ATOM   2533 C  CB  . LEU A 1 352 ? -26.986 -23.607 -5.620  1.00 31.31  ?  352 LEU A CB  1 
ATOM   2534 C  CG  . LEU A 1 352 ? -28.159 -22.621 -5.644  1.00 34.44  ?  352 LEU A CG  1 
ATOM   2535 C  CD1 . LEU A 1 352 ? -27.804 -21.413 -6.480  1.00 31.72  ?  352 LEU A CD1 1 
ATOM   2536 C  CD2 . LEU A 1 352 ? -29.387 -23.331 -6.218  1.00 34.94  ?  352 LEU A CD2 1 
ATOM   2537 N  N   . ALA A 1 353 ? -25.714 -26.533 -3.786  1.00 30.88  ?  353 ALA A N   1 
ATOM   2538 C  CA  . ALA A 1 353 ? -24.450 -27.270 -3.666  1.00 31.30  ?  353 ALA A CA  1 
ATOM   2539 C  C   . ALA A 1 353 ? -24.271 -28.275 -4.798  1.00 34.31  ?  353 ALA A C   1 
ATOM   2540 O  O   . ALA A 1 353 ? -23.135 -28.618 -5.157  1.00 31.80  ?  353 ALA A O   1 
ATOM   2541 C  CB  . ALA A 1 353 ? -24.384 -27.992 -2.317  1.00 30.30  ?  353 ALA A CB  1 
ATOM   2542 N  N   . PHE A 1 354 ? -25.377 -28.772 -5.357  1.00 31.49  ?  354 PHE A N   1 
ATOM   2543 C  CA  . PHE A 1 354 ? -25.349 -29.691 -6.488  1.00 33.06  ?  354 PHE A CA  1 
ATOM   2544 C  C   . PHE A 1 354 ? -25.664 -28.989 -7.805  1.00 35.39  ?  354 PHE A C   1 
ATOM   2545 O  O   . PHE A 1 354 ? -25.893 -29.662 -8.818  1.00 35.78  ?  354 PHE A O   1 
ATOM   2546 C  CB  . PHE A 1 354 ? -26.338 -30.839 -6.269  1.00 32.99  ?  354 PHE A CB  1 
ATOM   2547 C  CG  . PHE A 1 354 ? -25.897 -31.855 -5.249  1.00 32.36  ?  354 PHE A CG  1 
ATOM   2548 C  CD1 . PHE A 1 354 ? -24.717 -32.567 -5.414  1.00 32.57  ?  354 PHE A CD1 1 
ATOM   2549 C  CD2 . PHE A 1 354 ? -26.660 -32.086 -4.116  1.00 33.66  ?  354 PHE A CD2 1 
ATOM   2550 C  CE1 . PHE A 1 354 ? -24.317 -33.506 -4.470  1.00 33.53  ?  354 PHE A CE1 1 
ATOM   2551 C  CE2 . PHE A 1 354 ? -26.261 -33.015 -3.167  1.00 34.63  ?  354 PHE A CE2 1 
ATOM   2552 C  CZ  . PHE A 1 354 ? -25.087 -33.727 -3.350  1.00 31.35  ?  354 PHE A CZ  1 
ATOM   2553 N  N   . GLY A 1 355 ? -25.714 -27.656 -7.804  1.00 31.03  ?  355 GLY A N   1 
ATOM   2554 C  CA  . GLY A 1 355 ? -26.062 -26.923 -8.997  1.00 31.68  ?  355 GLY A CA  1 
ATOM   2555 C  C   . GLY A 1 355 ? -27.564 -26.769 -9.132  1.00 36.35  ?  355 GLY A C   1 
ATOM   2556 O  O   . GLY A 1 355 ? -28.285 -26.702 -8.132  1.00 32.77  ?  355 GLY A O   1 
ATOM   2557 N  N   . GLY A 1 356 ? -28.043 -26.722 -10.365 1.00 36.28  ?  356 GLY A N   1 
ATOM   2558 C  CA  . GLY A 1 356 ? -29.464 -26.548 -10.623 1.00 38.00  ?  356 GLY A CA  1 
ATOM   2559 C  C   . GLY A 1 356 ? -29.699 -26.591 -12.115 1.00 39.62  ?  356 GLY A C   1 
ATOM   2560 O  O   . GLY A 1 356 ? -28.761 -26.526 -12.918 1.00 38.27  ?  356 GLY A O   1 
ATOM   2561 N  N   . GLY A 1 357 ? -30.975 -26.728 -12.477 1.00 42.03  ?  357 GLY A N   1 
ATOM   2562 C  CA  . GLY A 1 357 ? -31.323 -26.730 -13.884 1.00 39.24  ?  357 GLY A CA  1 
ATOM   2563 C  C   . GLY A 1 357 ? -30.858 -27.990 -14.593 1.00 38.75  ?  357 GLY A C   1 
ATOM   2564 O  O   . GLY A 1 357 ? -30.768 -29.074 -14.008 1.00 39.81  ?  357 GLY A O   1 
ATOM   2565 N  N   . GLN A 1 358 ? -30.548 -27.833 -15.884 1.00 37.86  ?  358 GLN A N   1 
ATOM   2566 C  CA  . GLN A 1 358 ? -30.257 -28.986 -16.730 1.00 41.79  ?  358 GLN A CA  1 
ATOM   2567 C  C   . GLN A 1 358 ? -29.060 -29.786 -16.229 1.00 39.04  ?  358 GLN A C   1 
ATOM   2568 O  O   . GLN A 1 358 ? -29.045 -31.016 -16.352 1.00 36.82  ?  358 GLN A O   1 
ATOM   2569 C  CB  . GLN A 1 358 ? -30.010 -28.528 -18.169 1.00 43.42  ?  358 GLN A CB  1 
ATOM   2570 C  CG  . GLN A 1 358 ? -29.475 -29.621 -19.094 1.00 45.26  ?  358 GLN A CG  1 
ATOM   2571 C  CD  . GLN A 1 358 ? -29.012 -29.088 -20.440 1.00 50.64  ?  358 GLN A CD  1 
ATOM   2572 O  OE1 . GLN A 1 358 ? -29.214 -27.915 -20.770 1.00 52.34  ?  358 GLN A OE1 1 
ATOM   2573 N  NE2 . GLN A 1 358 ? -28.374 -29.952 -21.224 1.00 53.44  ?  358 GLN A NE2 1 
ATOM   2574 N  N   . HIS A 1 359 ? -28.049 -29.123 -15.668 1.00 38.09  ?  359 HIS A N   1 
ATOM   2575 C  CA  . HIS A 1 359 ? -26.806 -29.794 -15.307 1.00 38.90  ?  359 HIS A CA  1 
ATOM   2576 C  C   . HIS A 1 359 ? -26.715 -30.136 -13.819 1.00 42.63  ?  359 HIS A C   1 
ATOM   2577 O  O   . HIS A 1 359 ? -25.623 -30.487 -13.337 1.00 37.87  ?  359 HIS A O   1 
ATOM   2578 C  CB  . HIS A 1 359 ? -25.619 -28.937 -15.751 1.00 36.42  ?  359 HIS A CB  1 
ATOM   2579 C  CG  . HIS A 1 359 ? -25.548 -28.757 -17.237 1.00 38.95  ?  359 HIS A CG  1 
ATOM   2580 N  ND1 . HIS A 1 359 ? -25.316 -29.808 -18.102 1.00 43.99  ?  359 HIS A ND1 1 
ATOM   2581 C  CD2 . HIS A 1 359 ? -25.711 -27.660 -18.013 1.00 40.15  ?  359 HIS A CD2 1 
ATOM   2582 C  CE1 . HIS A 1 359 ? -25.317 -29.359 -19.345 1.00 42.43  ?  359 HIS A CE1 1 
ATOM   2583 N  NE2 . HIS A 1 359 ? -25.552 -28.058 -19.318 1.00 41.27  ?  359 HIS A NE2 1 
ATOM   2584 N  N   . PHE A 1 360 ? -27.838 -30.063 -13.093 1.00 36.74  ?  360 PHE A N   1 
ATOM   2585 C  CA  . PHE A 1 360 ? -27.901 -30.512 -11.704 1.00 36.07  ?  360 PHE A CA  1 
ATOM   2586 C  C   . PHE A 1 360 ? -27.229 -31.871 -11.558 1.00 38.74  ?  360 PHE A C   1 
ATOM   2587 O  O   . PHE A 1 360 ? -27.401 -32.759 -12.395 1.00 35.38  ?  360 PHE A O   1 
ATOM   2588 C  CB  . PHE A 1 360 ? -29.370 -30.585 -11.259 1.00 39.66  ?  360 PHE A CB  1 
ATOM   2589 C  CG  . PHE A 1 360 ? -29.566 -30.948 -9.812  1.00 38.12  ?  360 PHE A CG  1 
ATOM   2590 C  CD1 . PHE A 1 360 ? -29.590 -29.961 -8.829  1.00 37.26  ?  360 PHE A CD1 1 
ATOM   2591 C  CD2 . PHE A 1 360 ? -29.767 -32.267 -9.436  1.00 40.68  ?  360 PHE A CD2 1 
ATOM   2592 C  CE1 . PHE A 1 360 ? -29.794 -30.294 -7.498  1.00 38.21  ?  360 PHE A CE1 1 
ATOM   2593 C  CE2 . PHE A 1 360 ? -29.963 -32.607 -8.104  1.00 38.83  ?  360 PHE A CE2 1 
ATOM   2594 C  CZ  . PHE A 1 360 ? -29.976 -31.610 -7.137  1.00 38.85  ?  360 PHE A CZ  1 
ATOM   2595 N  N   . CYS A 1 361 ? -26.437 -32.021 -10.499 1.00 36.17  ?  361 CYS A N   1 
ATOM   2596 C  CA  . CYS A 1 361 ? -25.621 -33.214 -10.314 1.00 35.47  ?  361 CYS A CA  1 
ATOM   2597 C  C   . CYS A 1 361 ? -26.457 -34.493 -10.459 1.00 35.21  ?  361 CYS A C   1 
ATOM   2598 O  O   . CYS A 1 361 ? -27.404 -34.700 -9.689  1.00 32.21  ?  361 CYS A O   1 
ATOM   2599 C  CB  . CYS A 1 361 ? -24.938 -33.195 -8.944  1.00 30.42  ?  361 CYS A CB  1 
ATOM   2600 S  SG  . CYS A 1 361 ? -23.993 -34.706 -8.657  1.00 34.01  ?  361 CYS A SG  1 
ATOM   2601 N  N   . PRO A 1 362 ? -26.146 -35.360 -11.427 1.00 34.78  ?  362 PRO A N   1 
ATOM   2602 C  CA  . PRO A 1 362 ? -26.903 -36.613 -11.564 1.00 34.98  ?  362 PRO A CA  1 
ATOM   2603 C  C   . PRO A 1 362 ? -26.581 -37.625 -10.487 1.00 37.81  ?  362 PRO A C   1 
ATOM   2604 O  O   . PRO A 1 362 ? -27.242 -38.666 -10.439 1.00 37.00  ?  362 PRO A O   1 
ATOM   2605 C  CB  . PRO A 1 362 ? -26.472 -37.135 -12.939 1.00 40.46  ?  362 PRO A CB  1 
ATOM   2606 C  CG  . PRO A 1 362 ? -25.042 -36.610 -13.081 1.00 38.92  ?  362 PRO A CG  1 
ATOM   2607 C  CD  . PRO A 1 362 ? -25.094 -35.224 -12.454 1.00 35.53  ?  362 PRO A CD  1 
ATOM   2608 N  N   . ALA A 1 363 ? -25.579 -37.369 -9.637  1.00 33.57  ?  363 ALA A N   1 
ATOM   2609 C  CA  . ALA A 1 363 ? -25.186 -38.303 -8.592  1.00 35.97  ?  363 ALA A CA  1 
ATOM   2610 C  C   . ALA A 1 363 ? -25.457 -37.751 -7.198  1.00 34.31  ?  363 ALA A C   1 
ATOM   2611 O  O   . ALA A 1 363 ? -24.819 -38.180 -6.235  1.00 34.28  ?  363 ALA A O   1 
ATOM   2612 C  CB  . ALA A 1 363 ? -23.707 -38.674 -8.739  1.00 33.26  ?  363 ALA A CB  1 
ATOM   2613 N  N   . SER A 1 364 ? -26.402 -36.815 -7.068  1.00 34.05  ?  364 SER A N   1 
ATOM   2614 C  CA  . SER A 1 364 ? -26.609 -36.169 -5.775  1.00 33.14  ?  364 SER A CA  1 
ATOM   2615 C  C   . SER A 1 364 ? -27.008 -37.174 -4.704  1.00 34.96  ?  364 SER A C   1 
ATOM   2616 O  O   . SER A 1 364 ? -26.556 -37.073 -3.557  1.00 35.03  ?  364 SER A O   1 
ATOM   2617 C  CB  . SER A 1 364 ? -27.652 -35.054 -5.895  1.00 35.80  ?  364 SER A CB  1 
ATOM   2618 O  OG  . SER A 1 364 ? -28.938 -35.570 -6.199  1.00 36.58  ?  364 SER A OG  1 
ATOM   2619 N  N   . ALA A 1 365 ? -27.824 -38.175 -5.059  1.00 36.28  ?  365 ALA A N   1 
ATOM   2620 C  CA  . ALA A 1 365 ? -28.208 -39.177 -4.066  1.00 34.27  ?  365 ALA A CA  1 
ATOM   2621 C  C   . ALA A 1 365 ? -27.002 -39.986 -3.610  1.00 33.50  ?  365 ALA A C   1 
ATOM   2622 O  O   . ALA A 1 365 ? -26.858 -40.296 -2.421  1.00 36.13  ?  365 ALA A O   1 
ATOM   2623 C  CB  . ALA A 1 365 ? -29.288 -40.106 -4.631  1.00 41.92  ?  365 ALA A CB  1 
ATOM   2624 N  N   . LEU A 1 366 ? -26.136 -40.363 -4.548  1.00 35.44  ?  366 LEU A N   1 
ATOM   2625 C  CA  . LEU A 1 366 ? -24.923 -41.081 -4.181  1.00 37.19  ?  366 LEU A CA  1 
ATOM   2626 C  C   . LEU A 1 366 ? -23.994 -40.190 -3.362  1.00 34.89  ?  366 LEU A C   1 
ATOM   2627 O  O   . LEU A 1 366 ? -23.380 -40.644 -2.391  1.00 32.80  ?  366 LEU A O   1 
ATOM   2628 C  CB  . LEU A 1 366 ? -24.227 -41.569 -5.448  1.00 38.41  ?  366 LEU A CB  1 
ATOM   2629 C  CG  . LEU A 1 366 ? -22.963 -42.408 -5.330  1.00 43.70  ?  366 LEU A CG  1 
ATOM   2630 C  CD1 . LEU A 1 366 ? -23.191 -43.637 -4.477  1.00 43.33  ?  366 LEU A CD1 1 
ATOM   2631 C  CD2 . LEU A 1 366 ? -22.551 -42.809 -6.716  1.00 45.79  ?  366 LEU A CD2 1 
ATOM   2632 N  N   . GLY A 1 367 ? -23.896 -38.916 -3.739  1.00 32.10  ?  367 GLY A N   1 
ATOM   2633 C  CA  . GLY A 1 367 ? -23.079 -37.987 -2.972  1.00 35.11  ?  367 GLY A CA  1 
ATOM   2634 C  C   . GLY A 1 367 ? -23.544 -37.876 -1.533  1.00 33.70  ?  367 GLY A C   1 
ATOM   2635 O  O   . GLY A 1 367 ? -22.730 -37.909 -0.604  1.00 30.40  ?  367 GLY A O   1 
ATOM   2636 N  N   . ARG A 1 368 ? -24.863 -37.786 -1.327  1.00 32.19  ?  368 ARG A N   1 
ATOM   2637 C  CA  . ARG A 1 368 ? -25.398 -37.719 0.030   1.00 31.04  ?  368 ARG A CA  1 
ATOM   2638 C  C   . ARG A 1 368 ? -25.128 -39.011 0.786   1.00 32.68  ?  368 ARG A C   1 
ATOM   2639 O  O   . ARG A 1 368 ? -24.714 -38.988 1.951   1.00 32.83  ?  368 ARG A O   1 
ATOM   2640 C  CB  . ARG A 1 368 ? -26.903 -37.440 -0.001  1.00 33.74  ?  368 ARG A CB  1 
ATOM   2641 C  CG  . ARG A 1 368 ? -27.307 -36.069 -0.552  1.00 32.41  ?  368 ARG A CG  1 
ATOM   2642 C  CD  . ARG A 1 368 ? -28.841 -36.040 -0.773  1.00 36.77  ?  368 ARG A CD  1 
ATOM   2643 N  NE  . ARG A 1 368 ? -29.291 -34.782 -1.356  1.00 34.38  ?  368 ARG A NE  1 
ATOM   2644 C  CZ  . ARG A 1 368 ? -29.408 -33.648 -0.682  1.00 37.86  ?  368 ARG A CZ  1 
ATOM   2645 N  NH1 . ARG A 1 368 ? -29.147 -33.586 0.617   1.00 35.41  ?  368 ARG A NH1 1 
ATOM   2646 N  NH2 . ARG A 1 368 ? -29.785 -32.544 -1.327  1.00 36.06  ?  368 ARG A NH2 1 
ATOM   2647 N  N   . THR A 1 369 ? -25.349 -40.156 0.130   1.00 31.88  ?  369 THR A N   1 
ATOM   2648 C  CA  . THR A 1 369 ? -25.113 -41.447 0.775   1.00 32.84  ?  369 THR A CA  1 
ATOM   2649 C  C   . THR A 1 369 ? -23.664 -41.590 1.211   1.00 31.65  ?  369 THR A C   1 
ATOM   2650 O  O   . THR A 1 369 ? -23.381 -42.008 2.339   1.00 33.70  ?  369 THR A O   1 
ATOM   2651 C  CB  . THR A 1 369 ? -25.481 -42.589 -0.181  1.00 36.32  ?  369 THR A CB  1 
ATOM   2652 O  OG1 . THR A 1 369 ? -26.851 -42.459 -0.558  1.00 38.55  ?  369 THR A OG1 1 
ATOM   2653 C  CG2 . THR A 1 369 ? -25.274 -43.946 0.496   1.00 37.20  ?  369 THR A CG2 1 
ATOM   2654 N  N   . HIS A 1 370 ? -22.734 -41.305 0.296   1.00 33.67  ?  370 HIS A N   1 
ATOM   2655 C  CA  . HIS A 1 370 ? -21.306 -41.324 0.600   1.00 29.43  ?  370 HIS A CA  1 
ATOM   2656 C  C   . HIS A 1 370 ? -21.013 -40.578 1.899   1.00 28.59  ?  370 HIS A C   1 
ATOM   2657 O  O   . HIS A 1 370 ? -20.403 -41.131 2.821   1.00 30.70  ?  370 HIS A O   1 
ATOM   2658 C  CB  . HIS A 1 370 ? -20.546 -40.708 -0.588  1.00 28.97  ?  370 HIS A CB  1 
ATOM   2659 C  CG  . HIS A 1 370 ? -19.089 -40.449 -0.343  1.00 29.32  ?  370 HIS A CG  1 
ATOM   2660 N  ND1 . HIS A 1 370 ? -18.629 -39.356 0.370   1.00 32.93  ?  370 HIS A ND1 1 
ATOM   2661 C  CD2 . HIS A 1 370 ? -17.986 -41.110 -0.771  1.00 30.70  ?  370 HIS A CD2 1 
ATOM   2662 C  CE1 . HIS A 1 370 ? -17.305 -39.373 0.393   1.00 31.18  ?  370 HIS A CE1 1 
ATOM   2663 N  NE2 . HIS A 1 370 ? -16.891 -40.430 -0.290  1.00 32.56  ?  370 HIS A NE2 1 
ATOM   2664 N  N   . ALA A 1 371 ? -21.477 -39.328 1.998   1.00 27.16  ?  371 ALA A N   1 
ATOM   2665 C  CA  . ALA A 1 371 ? -21.173 -38.493 3.160   1.00 30.97  ?  371 ALA A CA  1 
ATOM   2666 C  C   . ALA A 1 371 ? -21.947 -38.925 4.399   1.00 28.44  ?  371 ALA A C   1 
ATOM   2667 O  O   . ALA A 1 371 ? -21.382 -38.969 5.496   1.00 29.41  ?  371 ALA A O   1 
ATOM   2668 C  CB  . ALA A 1 371 ? -21.455 -37.014 2.842   1.00 29.23  ?  371 ALA A CB  1 
ATOM   2669 N  N   . GLU A 1 372 ? -23.235 -39.242 4.259   1.00 28.69  ?  372 GLU A N   1 
ATOM   2670 C  CA  . GLU A 1 372 ? -24.024 -39.628 5.435   1.00 29.79  ?  372 GLU A CA  1 
ATOM   2671 C  C   . GLU A 1 372 ? -23.420 -40.839 6.129   1.00 31.15  ?  372 GLU A C   1 
ATOM   2672 O  O   . GLU A 1 372 ? -23.227 -40.848 7.350   1.00 29.07  ?  372 GLU A O   1 
ATOM   2673 C  CB  . GLU A 1 372 ? -25.479 -39.920 5.036   1.00 30.93  ?  372 GLU A CB  1 
ATOM   2674 C  CG  . GLU A 1 372 ? -26.254 -38.683 4.578   1.00 32.83  ?  372 GLU A CG  1 
ATOM   2675 C  CD  . GLU A 1 372 ? -27.645 -39.026 4.034   1.00 37.95  ?  372 GLU A CD  1 
ATOM   2676 O  OE1 . GLU A 1 372 ? -28.175 -40.104 4.371   1.00 41.41  ?  372 GLU A OE1 1 
ATOM   2677 O  OE2 . GLU A 1 372 ? -28.209 -38.215 3.280   1.00 36.82  ?  372 GLU A OE2 1 
ATOM   2678 N  N   . ILE A 1 373 ? -23.085 -41.867 5.352   1.00 29.30  ?  373 ILE A N   1 
ATOM   2679 C  CA  . ILE A 1 373 ? -22.529 -43.080 5.934   1.00 30.36  ?  373 ILE A CA  1 
ATOM   2680 C  C   . ILE A 1 373 ? -21.162 -42.808 6.556   1.00 30.05  ?  373 ILE A C   1 
ATOM   2681 O  O   . ILE A 1 373 ? -20.876 -43.265 7.667   1.00 28.08  ?  373 ILE A O   1 
ATOM   2682 C  CB  . ILE A 1 373 ? -22.484 -44.195 4.867   1.00 31.58  ?  373 ILE A CB  1 
ATOM   2683 C  CG1 . ILE A 1 373 ? -23.914 -44.618 4.505   1.00 35.12  ?  373 ILE A CG1 1 
ATOM   2684 C  CG2 . ILE A 1 373 ? -21.684 -45.405 5.369   1.00 31.89  ?  373 ILE A CG2 1 
ATOM   2685 C  CD1 . ILE A 1 373 ? -23.990 -45.752 3.462   1.00 32.54  ?  373 ILE A CD1 1 
ATOM   2686 N  N   . ALA A 1 374 ? -20.304 -42.036 5.877   1.00 29.18  ?  374 ALA A N   1 
ATOM   2687 C  CA  . ALA A 1 374 ? -18.983 -41.758 6.434   1.00 30.03  ?  374 ALA A CA  1 
ATOM   2688 C  C   . ALA A 1 374 ? -19.085 -40.991 7.746   1.00 27.86  ?  374 ALA A C   1 
ATOM   2689 O  O   . ALA A 1 374 ? -18.380 -41.297 8.715   1.00 29.73  ?  374 ALA A O   1 
ATOM   2690 C  CB  . ALA A 1 374 ? -18.128 -40.974 5.432   1.00 28.61  ?  374 ALA A CB  1 
ATOM   2691 N  N   . LEU A 1 375 ? -19.942 -39.968 7.790   1.00 28.03  ?  375 LEU A N   1 
ATOM   2692 C  CA  . LEU A 1 375 ? -19.998 -39.121 8.978   1.00 28.68  ?  375 LEU A CA  1 
ATOM   2693 C  C   . LEU A 1 375 ? -20.646 -39.866 10.135  1.00 27.83  ?  375 LEU A C   1 
ATOM   2694 O  O   . LEU A 1 375 ? -20.252 -39.693 11.290  1.00 28.55  ?  375 LEU A O   1 
ATOM   2695 C  CB  . LEU A 1 375 ? -20.753 -37.825 8.667   1.00 29.14  ?  375 LEU A CB  1 
ATOM   2696 C  CG  . LEU A 1 375 ? -20.032 -36.932 7.653   1.00 28.30  ?  375 LEU A CG  1 
ATOM   2697 C  CD1 . LEU A 1 375 ? -20.905 -35.744 7.260   1.00 29.39  ?  375 LEU A CD1 1 
ATOM   2698 C  CD2 . LEU A 1 375 ? -18.660 -36.469 8.197   1.00 28.09  ?  375 LEU A CD2 1 
ATOM   2699 N  N   . THR A 1 376 ? -21.631 -40.721 9.841   1.00 30.58  ?  376 THR A N   1 
ATOM   2700 C  CA  . THR A 1 376 ? -22.213 -41.548 10.894  1.00 29.73  ?  376 THR A CA  1 
ATOM   2701 C  C   . THR A 1 376 ? -21.146 -42.442 11.517  1.00 31.91  ?  376 THR A C   1 
ATOM   2702 O  O   . THR A 1 376 ? -21.021 -42.526 12.746  1.00 31.95  ?  376 THR A O   1 
ATOM   2703 C  CB  . THR A 1 376 ? -23.372 -42.376 10.322  1.00 31.45  ?  376 THR A CB  1 
ATOM   2704 O  OG1 . THR A 1 376 ? -24.421 -41.502 9.887   1.00 31.35  ?  376 THR A OG1 1 
ATOM   2705 C  CG2 . THR A 1 376 ? -23.930 -43.346 11.369  1.00 38.24  ?  376 THR A CG2 1 
ATOM   2706 N  N   . ALA A 1 377 ? -20.337 -43.095 10.678  1.00 30.93  ?  377 ALA A N   1 
ATOM   2707 C  CA  . ALA A 1 377 ? -19.245 -43.909 11.204  1.00 31.75  ?  377 ALA A CA  1 
ATOM   2708 C  C   . ALA A 1 377 ? -18.258 -43.058 11.996  1.00 31.20  ?  377 ALA A C   1 
ATOM   2709 O  O   . ALA A 1 377 ? -17.817 -43.442 13.085  1.00 29.29  ?  377 ALA A O   1 
ATOM   2710 C  CB  . ALA A 1 377 ? -18.532 -44.629 10.052  1.00 31.85  ?  377 ALA A CB  1 
ATOM   2711 N  N   . LEU A 1 378 ? -17.909 -41.886 11.465  1.00 29.28  ?  378 LEU A N   1 
ATOM   2712 C  CA  . LEU A 1 378 ? -16.909 -41.033 12.105  1.00 30.63  ?  378 LEU A CA  1 
ATOM   2713 C  C   . LEU A 1 378 ? -17.330 -40.609 13.513  1.00 29.80  ?  378 LEU A C   1 
ATOM   2714 O  O   . LEU A 1 378 ? -16.546 -40.712 14.466  1.00 29.53  ?  378 LEU A O   1 
ATOM   2715 C  CB  . LEU A 1 378 ? -16.664 -39.809 11.223  1.00 30.11  ?  378 LEU A CB  1 
ATOM   2716 C  CG  . LEU A 1 378 ? -15.592 -38.831 11.656  1.00 35.35  ?  378 LEU A CG  1 
ATOM   2717 C  CD1 . LEU A 1 378 ? -14.214 -39.410 11.418  1.00 34.92  ?  378 LEU A CD1 1 
ATOM   2718 C  CD2 . LEU A 1 378 ? -15.797 -37.579 10.819  1.00 34.67  ?  378 LEU A CD2 1 
ATOM   2719 N  N   . VAL A 1 379 ? -18.566 -40.127 13.675  1.00 30.16  ?  379 VAL A N   1 
ATOM   2720 C  CA  . VAL A 1 379 ? -18.935 -39.609 14.992  1.00 30.74  ?  379 VAL A CA  1 
ATOM   2721 C  C   . VAL A 1 379 ? -19.104 -40.746 15.991  1.00 33.96  ?  379 VAL A C   1 
ATOM   2722 O  O   . VAL A 1 379 ? -18.913 -40.554 17.199  1.00 34.45  ?  379 VAL A O   1 
ATOM   2723 C  CB  . VAL A 1 379 ? -20.200 -38.732 14.923  1.00 31.29  ?  379 VAL A CB  1 
ATOM   2724 C  CG1 . VAL A 1 379 ? -19.966 -37.526 14.006  1.00 27.84  ?  379 VAL A CG1 1 
ATOM   2725 C  CG2 . VAL A 1 379 ? -21.422 -39.548 14.467  1.00 30.85  ?  379 VAL A CG2 1 
ATOM   2726 N  N   . GLU A 1 380 ? -19.448 -41.941 15.518  1.00 32.98  ?  380 GLU A N   1 
ATOM   2727 C  CA  . GLU A 1 380 ? -19.504 -43.094 16.412  1.00 34.18  ?  380 GLU A CA  1 
ATOM   2728 C  C   . GLU A 1 380 ? -18.106 -43.517 16.859  1.00 35.62  ?  380 GLU A C   1 
ATOM   2729 O  O   . GLU A 1 380 ? -17.865 -43.730 18.055  1.00 36.41  ?  380 GLU A O   1 
ATOM   2730 C  CB  . GLU A 1 380 ? -20.226 -44.251 15.716  1.00 37.70  ?  380 GLU A CB  1 
ATOM   2731 C  CG  . GLU A 1 380 ? -20.123 -45.579 16.441  1.00 45.92  ?  380 GLU A CG  1 
ATOM   2732 C  CD  . GLU A 1 380 ? -20.575 -46.754 15.573  1.00 54.85  ?  380 GLU A CD  1 
ATOM   2733 O  OE1 . GLU A 1 380 ? -21.446 -46.552 14.691  1.00 59.90  ?  380 GLU A OE1 1 
ATOM   2734 O  OE2 . GLU A 1 380 ? -20.047 -47.874 15.765  1.00 60.42  ?  380 GLU A OE2 1 
ATOM   2735 N  N   . LYS A 1 381 ? -17.160 -43.623 15.911  1.00 32.19  ?  381 LYS A N   1 
ATOM   2736 C  CA  . LYS A 1 381 ? -15.849 -44.209 16.193  1.00 32.72  ?  381 LYS A CA  1 
ATOM   2737 C  C   . LYS A 1 381 ? -14.868 -43.228 16.820  1.00 35.01  ?  381 LYS A C   1 
ATOM   2738 O  O   . LYS A 1 381 ? -14.011 -43.640 17.604  1.00 32.11  ?  381 LYS A O   1 
ATOM   2739 C  CB  . LYS A 1 381 ? -15.229 -44.773 14.907  1.00 33.67  ?  381 LYS A CB  1 
ATOM   2740 C  CG  . LYS A 1 381 ? -15.821 -46.138 14.518  1.00 37.27  ?  381 LYS A CG  1 
ATOM   2741 C  CD  . LYS A 1 381 ? -15.277 -47.232 15.448  1.00 40.89  ?  381 LYS A CD  1 
ATOM   2742 C  CE  . LYS A 1 381 ? -16.044 -48.552 15.280  1.00 46.86  ?  381 LYS A CE  1 
ATOM   2743 N  NZ  . LYS A 1 381 ? -15.517 -49.372 14.160  1.00 44.45  ?  381 LYS A NZ  1 
ATOM   2744 N  N   . LEU A 1 382 ? -14.929 -41.944 16.461  1.00 33.54  ?  382 LEU A N   1 
ATOM   2745 C  CA  . LEU A 1 382 ? -14.031 -40.926 17.007  1.00 30.76  ?  382 LEU A CA  1 
ATOM   2746 C  C   . LEU A 1 382 ? -14.872 -39.867 17.719  1.00 34.68  ?  382 LEU A C   1 
ATOM   2747 O  O   . LEU A 1 382 ? -14.988 -38.737 17.234  1.00 31.92  ?  382 LEU A O   1 
ATOM   2748 C  CB  . LEU A 1 382 ? -13.180 -40.281 15.911  1.00 29.54  ?  382 LEU A CB  1 
ATOM   2749 C  CG  . LEU A 1 382 ? -12.525 -41.182 14.846  1.00 33.82  ?  382 LEU A CG  1 
ATOM   2750 C  CD1 . LEU A 1 382 ? -11.558 -40.371 13.997  1.00 32.17  ?  382 LEU A CD1 1 
ATOM   2751 C  CD2 . LEU A 1 382 ? -11.780 -42.358 15.475  1.00 31.51  ?  382 LEU A CD2 1 
ATOM   2752 N  N   . PRO A 1 383 ? -15.473 -40.194 18.872  1.00 34.57  ?  383 PRO A N   1 
ATOM   2753 C  CA  . PRO A 1 383 ? -16.384 -39.225 19.509  1.00 33.56  ?  383 PRO A CA  1 
ATOM   2754 C  C   . PRO A 1 383 ? -15.697 -37.971 20.028  1.00 32.32  ?  383 PRO A C   1 
ATOM   2755 O  O   . PRO A 1 383 ? -16.374 -36.947 20.194  1.00 33.21  ?  383 PRO A O   1 
ATOM   2756 C  CB  . PRO A 1 383 ? -17.026 -40.030 20.652  1.00 34.24  ?  383 PRO A CB  1 
ATOM   2757 C  CG  . PRO A 1 383 ? -16.048 -41.143 20.930  1.00 34.28  ?  383 PRO A CG  1 
ATOM   2758 C  CD  . PRO A 1 383 ? -15.460 -41.485 19.588  1.00 35.16  ?  383 PRO A CD  1 
ATOM   2759 N  N   . ALA A 1 384 ? -14.385 -37.990 20.279  1.00 32.28  ?  384 ALA A N   1 
ATOM   2760 C  CA  . ALA A 1 384 ? -13.688 -36.787 20.726  1.00 32.37  ?  384 ALA A CA  1 
ATOM   2761 C  C   . ALA A 1 384 ? -12.939 -36.094 19.588  1.00 35.04  ?  384 ALA A C   1 
ATOM   2762 O  O   . ALA A 1 384 ? -12.003 -35.322 19.843  1.00 31.84  ?  384 ALA A O   1 
ATOM   2763 C  CB  . ALA A 1 384 ? -12.729 -37.120 21.871  1.00 35.92  ?  384 ALA A CB  1 
ATOM   2764 N  N   . LEU A 1 385 ? -13.327 -36.376 18.345  1.00 29.50  ?  385 LEU A N   1 
ATOM   2765 C  CA  . LEU A 1 385 ? -12.698 -35.800 17.161  1.00 31.73  ?  385 LEU A CA  1 
ATOM   2766 C  C   . LEU A 1 385 ? -12.501 -34.291 17.288  1.00 31.89  ?  385 LEU A C   1 
ATOM   2767 O  O   . LEU A 1 385 ? -13.437 -33.559 17.615  1.00 29.79  ?  385 LEU A O   1 
ATOM   2768 C  CB  . LEU A 1 385 ? -13.572 -36.102 15.947  1.00 26.96  ?  385 LEU A CB  1 
ATOM   2769 C  CG  . LEU A 1 385 ? -13.111 -35.481 14.627  1.00 32.20  ?  385 LEU A CG  1 
ATOM   2770 C  CD1 . LEU A 1 385 ? -11.936 -36.273 14.041  1.00 30.94  ?  385 LEU A CD1 1 
ATOM   2771 C  CD2 . LEU A 1 385 ? -14.270 -35.455 13.652  1.00 31.47  ?  385 LEU A CD2 1 
ATOM   2772 N  N   . ARG A 1 386 ? -11.283 -33.835 16.998  1.00 28.01  ?  386 ARG A N   1 
ATOM   2773 C  CA  . ARG A 1 386 ? -10.945 -32.418 16.966  1.00 29.16  ?  386 ARG A CA  1 
ATOM   2774 C  C   . ARG A 1 386 ? -9.698  -32.253 16.105  1.00 31.48  ?  386 ARG A C   1 
ATOM   2775 O  O   . ARG A 1 386 ? -8.951  -33.207 15.889  1.00 27.73  ?  386 ARG A O   1 
ATOM   2776 C  CB  . ARG A 1 386 ? -10.693 -31.874 18.379  1.00 30.47  ?  386 ARG A CB  1 
ATOM   2777 C  CG  . ARG A 1 386 ? -9.474  -32.529 19.062  1.00 29.76  ?  386 ARG A CG  1 
ATOM   2778 C  CD  . ARG A 1 386 ? -9.576  -32.386 20.597  1.00 36.41  ?  386 ARG A CD  1 
ATOM   2779 N  NE  . ARG A 1 386 ? -8.461  -33.010 21.303  1.00 33.77  ?  386 ARG A NE  1 
ATOM   2780 C  CZ  . ARG A 1 386 ? -8.439  -34.272 21.710  1.00 36.51  ?  386 ARG A CZ  1 
ATOM   2781 N  NH1 . ARG A 1 386 ? -9.433  -35.105 21.446  1.00 32.83  ?  386 ARG A NH1 1 
ATOM   2782 N  NH2 . ARG A 1 386 ? -7.399  -34.709 22.414  1.00 36.26  ?  386 ARG A NH2 1 
ATOM   2783 N  N   . LEU A 1 387 ? -9.465  -31.035 15.623  1.00 27.56  ?  387 LEU A N   1 
ATOM   2784 C  CA  . LEU A 1 387 ? -8.250  -30.795 14.851  1.00 27.13  ?  387 LEU A CA  1 
ATOM   2785 C  C   . LEU A 1 387 ? -7.030  -30.918 15.754  1.00 29.37  ?  387 LEU A C   1 
ATOM   2786 O  O   . LEU A 1 387 ? -7.089  -30.629 16.949  1.00 28.25  ?  387 LEU A O   1 
ATOM   2787 C  CB  . LEU A 1 387 ? -8.283  -29.410 14.201  1.00 29.40  ?  387 LEU A CB  1 
ATOM   2788 C  CG  . LEU A 1 387 ? -9.397  -29.196 13.179  1.00 28.68  ?  387 LEU A CG  1 
ATOM   2789 C  CD1 . LEU A 1 387 ? -9.202  -27.845 12.531  1.00 29.86  ?  387 LEU A CD1 1 
ATOM   2790 C  CD2 . LEU A 1 387 ? -9.364  -30.288 12.127  1.00 30.70  ?  387 LEU A CD2 1 
ATOM   2791 N  N   . ALA A 1 388 ? -5.913  -31.368 15.175  1.00 26.55  ?  388 ALA A N   1 
ATOM   2792 C  CA  . ALA A 1 388 ? -4.676  -31.561 15.971  1.00 27.89  ?  388 ALA A CA  1 
ATOM   2793 C  C   . ALA A 1 388 ? -3.810  -30.299 15.938  1.00 31.38  ?  388 ALA A C   1 
ATOM   2794 O  O   . ALA A 1 388 ? -2.643  -30.364 16.381  1.00 30.37  ?  388 ALA A O   1 
ATOM   2795 C  CB  . ALA A 1 388 ? -3.804  -32.610 15.317  1.00 29.59  ?  388 ALA A CB  1 
ATOM   2796 N  N   . LEU A 1 389 ? -4.359  -29.190 15.436  1.00 29.75  ?  389 LEU A N   1 
ATOM   2797 C  CA  . LEU A 1 389 ? -3.599  -27.915 15.328  1.00 30.45  ?  389 LEU A CA  1 
ATOM   2798 C  C   . LEU A 1 389 ? -4.658  -26.830 15.081  1.00 30.82  ?  389 LEU A C   1 
ATOM   2799 O  O   . LEU A 1 389 ? -5.751  -27.196 14.591  1.00 31.67  ?  389 LEU A O   1 
ATOM   2800 C  CB  . LEU A 1 389 ? -2.491  -27.902 14.275  1.00 30.21  ?  389 LEU A CB  1 
ATOM   2801 C  CG  . LEU A 1 389 ? -1.727  -26.588 14.077  1.00 34.88  ?  389 LEU A CG  1 
ATOM   2802 C  CD1 . LEU A 1 389 ? -0.997  -26.243 15.361  1.00 35.23  ?  389 LEU A CD1 1 
ATOM   2803 C  CD2 . LEU A 1 389 ? -0.741  -26.627 12.920  1.00 33.40  ?  389 LEU A CD2 1 
ATOM   2804 N  N   . PRO A 1 390 ? -4.441  -25.530 15.394  1.00 33.15  ?  390 PRO A N   1 
ATOM   2805 C  CA  . PRO A 1 390 ? -5.465  -24.519 15.074  1.00 32.97  ?  390 PRO A CA  1 
ATOM   2806 C  C   . PRO A 1 390 ? -5.881  -24.578 13.612  1.00 32.17  ?  390 PRO A C   1 
ATOM   2807 O  O   . PRO A 1 390 ? -5.059  -24.809 12.722  1.00 29.50  ?  390 PRO A O   1 
ATOM   2808 C  CB  . PRO A 1 390 ? -4.776  -23.184 15.409  1.00 33.46  ?  390 PRO A CB  1 
ATOM   2809 C  CG  . PRO A 1 390 ? -3.771  -23.532 16.469  1.00 35.36  ?  390 PRO A CG  1 
ATOM   2810 C  CD  . PRO A 1 390 ? -3.299  -24.939 16.124  1.00 33.90  ?  390 PRO A CD  1 
ATOM   2811 N  N   . VAL A 1 391 ? -7.176  -24.338 13.374  1.00 27.06  ?  391 VAL A N   1 
ATOM   2812 C  CA  . VAL A 1 391 ? -7.715  -24.448 12.023  1.00 29.02  ?  391 VAL A CA  1 
ATOM   2813 C  C   . VAL A 1 391 ? -6.993  -23.506 11.069  1.00 31.81  ?  391 VAL A C   1 
ATOM   2814 O  O   . VAL A 1 391 ? -6.821  -23.831 9.887   1.00 27.35  ?  391 VAL A O   1 
ATOM   2815 C  CB  . VAL A 1 391 ? -9.243  -24.207 12.032  1.00 32.38  ?  391 VAL A CB  1 
ATOM   2816 C  CG1 . VAL A 1 391 ? -9.577  -22.745 12.366  1.00 33.61  ?  391 VAL A CG1 1 
ATOM   2817 C  CG2 . VAL A 1 391 ? -9.869  -24.618 10.694  1.00 30.68  ?  391 VAL A CG2 1 
ATOM   2818 N  N   . GLU A 1 392 ? -6.523  -22.342 11.558  1.00 30.52  ?  392 GLU A N   1 
ATOM   2819 C  CA  . GLU A 1 392 ? -5.839  -21.397 10.675  1.00 29.79  ?  392 GLU A CA  1 
ATOM   2820 C  C   . GLU A 1 392 ? -4.510  -21.923 10.160  1.00 32.01  ?  392 GLU A C   1 
ATOM   2821 O  O   . GLU A 1 392 ? -3.956  -21.335 9.228   1.00 29.17  ?  392 GLU A O   1 
ATOM   2822 C  CB  . GLU A 1 392 ? -5.565  -20.037 11.350  1.00 34.83  ?  392 GLU A CB  1 
ATOM   2823 C  CG  . GLU A 1 392 ? -6.769  -19.211 11.679  1.00 44.13  ?  392 GLU A CG  1 
ATOM   2824 C  CD  . GLU A 1 392 ? -6.374  -17.928 12.407  1.00 47.98  ?  392 GLU A CD  1 
ATOM   2825 O  OE1 . GLU A 1 392 ? -5.183  -17.841 12.789  1.00 44.33  ?  392 GLU A OE1 1 
ATOM   2826 O  OE2 . GLU A 1 392 ? -7.243  -17.009 12.594  1.00 55.43  ?  392 GLU A OE2 1 
ATOM   2827 N  N   . GLN A 1 393 ? -3.981  -23.004 10.728  1.00 29.07  ?  393 GLN A N   1 
ATOM   2828 C  CA  . GLN A 1 393 ? -2.704  -23.533 10.281  1.00 31.11  ?  393 GLN A CA  1 
ATOM   2829 C  C   . GLN A 1 393 ? -2.846  -24.728 9.350   1.00 28.18  ?  393 GLN A C   1 
ATOM   2830 O  O   . GLN A 1 393 ? -1.831  -25.293 8.949   1.00 28.54  ?  393 GLN A O   1 
ATOM   2831 C  CB  . GLN A 1 393 ? -1.821  -23.880 11.496  1.00 32.72  ?  393 GLN A CB  1 
ATOM   2832 C  CG  . GLN A 1 393 ? -1.507  -22.624 12.329  1.00 33.27  ?  393 GLN A CG  1 
ATOM   2833 C  CD  . GLN A 1 393 ? -0.810  -22.888 13.671  1.00 33.30  ?  393 GLN A CD  1 
ATOM   2834 O  OE1 . GLN A 1 393 ? -1.188  -22.316 14.697  1.00 36.20  ?  393 GLN A OE1 1 
ATOM   2835 N  NE2 . GLN A 1 393 ? 0.230   -23.709 13.655  1.00 32.12  ?  393 GLN A NE2 1 
ATOM   2836 N  N   . LEU A 1 394 ? -4.067  -25.096 8.950   1.00 28.45  ?  394 LEU A N   1 
ATOM   2837 C  CA  . LEU A 1 394 ? -4.217  -26.083 7.883   1.00 26.94  ?  394 LEU A CA  1 
ATOM   2838 C  C   . LEU A 1 394 ? -3.626  -25.532 6.590   1.00 31.11  ?  394 LEU A C   1 
ATOM   2839 O  O   . LEU A 1 394 ? -3.699  -24.330 6.317   1.00 28.05  ?  394 LEU A O   1 
ATOM   2840 C  CB  . LEU A 1 394 ? -5.690  -26.436 7.656   1.00 26.33  ?  394 LEU A CB  1 
ATOM   2841 C  CG  . LEU A 1 394 ? -6.449  -27.136 8.782   1.00 24.77  ?  394 LEU A CG  1 
ATOM   2842 C  CD1 . LEU A 1 394 ? -7.905  -27.268 8.399   1.00 26.68  ?  394 LEU A CD1 1 
ATOM   2843 C  CD2 . LEU A 1 394 ? -5.840  -28.529 9.010   1.00 25.94  ?  394 LEU A CD2 1 
ATOM   2844 N  N   . ALA A 1 395 ? -3.020  -26.413 5.797   1.00 26.89  ?  395 ALA A N   1 
ATOM   2845 C  CA  . ALA A 1 395 ? -2.491  -26.044 4.486   1.00 28.57  ?  395 ALA A CA  1 
ATOM   2846 C  C   . ALA A 1 395 ? -3.580  -26.266 3.442   1.00 27.29  ?  395 ALA A C   1 
ATOM   2847 O  O   . ALA A 1 395 ? -3.984  -27.405 3.192   1.00 30.10  ?  395 ALA A O   1 
ATOM   2848 C  CB  . ALA A 1 395 ? -1.260  -26.878 4.142   1.00 25.93  ?  395 ALA A CB  1 
ATOM   2849 N  N   . TRP A 1 396 ? -4.045  -25.191 2.827   1.00 25.61  ?  396 TRP A N   1 
ATOM   2850 C  CA  . TRP A 1 396 ? -5.075  -25.285 1.801   1.00 26.44  ?  396 TRP A CA  1 
ATOM   2851 C  C   . TRP A 1 396 ? -4.409  -25.380 0.435   1.00 28.08  ?  396 TRP A C   1 
ATOM   2852 O  O   . TRP A 1 396 ? -3.495  -24.608 0.123   1.00 25.99  ?  396 TRP A O   1 
ATOM   2853 C  CB  . TRP A 1 396 ? -6.023  -24.081 1.892   1.00 27.60  ?  396 TRP A CB  1 
ATOM   2854 C  CG  . TRP A 1 396 ? -6.839  -24.159 3.145   1.00 25.63  ?  396 TRP A CG  1 
ATOM   2855 C  CD1 . TRP A 1 396 ? -6.545  -23.597 4.354   1.00 28.87  ?  396 TRP A CD1 1 
ATOM   2856 C  CD2 . TRP A 1 396 ? -8.058  -24.887 3.323   1.00 28.02  ?  396 TRP A CD2 1 
ATOM   2857 N  NE1 . TRP A 1 396 ? -7.513  -23.941 5.280   1.00 28.83  ?  396 TRP A NE1 1 
ATOM   2858 C  CE2 . TRP A 1 396 ? -8.454  -24.724 4.663   1.00 30.12  ?  396 TRP A CE2 1 
ATOM   2859 C  CE3 . TRP A 1 396 ? -8.847  -25.681 2.476   1.00 29.15  ?  396 TRP A CE3 1 
ATOM   2860 C  CZ2 . TRP A 1 396 ? -9.621  -25.296 5.170   1.00 30.39  ?  396 TRP A CZ2 1 
ATOM   2861 C  CZ3 . TRP A 1 396 ? -10.001 -26.257 2.987   1.00 29.93  ?  396 TRP A CZ3 1 
ATOM   2862 C  CH2 . TRP A 1 396 ? -10.374 -26.060 4.320   1.00 31.37  ?  396 TRP A CH2 1 
ATOM   2863 N  N   . ARG A 1 397 ? -4.854  -26.337 -0.367  1.00 25.80  ?  397 ARG A N   1 
ATOM   2864 C  CA  . ARG A 1 397 ? -4.205  -26.587 -1.651  1.00 25.12  ?  397 ARG A CA  1 
ATOM   2865 C  C   . ARG A 1 397 ? -4.436  -25.422 -2.606  1.00 26.43  ?  397 ARG A C   1 
ATOM   2866 O  O   . ARG A 1 397 ? -5.584  -24.982 -2.769  1.00 24.40  ?  397 ARG A O   1 
ATOM   2867 C  CB  . ARG A 1 397 ? -4.744  -27.878 -2.288  1.00 24.53  ?  397 ARG A CB  1 
ATOM   2868 C  CG  . ARG A 1 397 ? -4.045  -28.184 -3.610  1.00 26.91  ?  397 ARG A CG  1 
ATOM   2869 C  CD  . ARG A 1 397 ? -4.626  -29.429 -4.274  1.00 28.45  ?  397 ARG A CD  1 
ATOM   2870 N  NE  . ARG A 1 397 ? -4.284  -30.620 -3.511  1.00 29.90  ?  397 ARG A NE  1 
ATOM   2871 C  CZ  . ARG A 1 397 ? -4.470  -31.855 -3.958  1.00 34.00  ?  397 ARG A CZ  1 
ATOM   2872 N  NH1 . ARG A 1 397 ? -4.928  -32.080 -5.181  1.00 30.03  ?  397 ARG A NH1 1 
ATOM   2873 N  NH2 . ARG A 1 397 ? -4.208  -32.886 -3.156  1.00 33.54  ?  397 ARG A NH2 1 
ATOM   2874 N  N   . PRO A 1 398 ? -3.392  -24.917 -3.266  1.00 26.38  ?  398 PRO A N   1 
ATOM   2875 C  CA  . PRO A 1 398 ? -3.569  -23.907 -4.312  1.00 25.41  ?  398 PRO A CA  1 
ATOM   2876 C  C   . PRO A 1 398 ? -3.813  -24.546 -5.673  1.00 28.81  ?  398 PRO A C   1 
ATOM   2877 O  O   . PRO A 1 398 ? -3.555  -25.732 -5.889  1.00 27.35  ?  398 PRO A O   1 
ATOM   2878 C  CB  . PRO A 1 398 ? -2.211  -23.177 -4.318  1.00 30.05  ?  398 PRO A CB  1 
ATOM   2879 C  CG  . PRO A 1 398 ? -1.237  -24.317 -4.049  1.00 26.80  ?  398 PRO A CG  1 
ATOM   2880 C  CD  . PRO A 1 398 ? -1.965  -25.253 -3.054  1.00 26.81  ?  398 PRO A CD  1 
ATOM   2881 N  N   . GLY A 1 399 ? -4.319  -23.726 -6.594  1.00 28.45  ?  399 GLY A N   1 
ATOM   2882 C  CA  . GLY A 1 399 ? -4.281  -24.072 -8.012  1.00 31.28  ?  399 GLY A CA  1 
ATOM   2883 C  C   . GLY A 1 399 ? -5.079  -25.300 -8.386  1.00 28.60  ?  399 GLY A C   1 
ATOM   2884 O  O   . GLY A 1 399 ? -4.686  -26.039 -9.295  1.00 28.66  ?  399 GLY A O   1 
ATOM   2885 N  N   . PHE A 1 400 ? -6.187  -25.541 -7.702  1.00 24.80  ?  400 PHE A N   1 
ATOM   2886 C  CA  . PHE A 1 400 ? -6.981  -26.750 -7.871  1.00 28.10  ?  400 PHE A CA  1 
ATOM   2887 C  C   . PHE A 1 400 ? -8.444  -26.346 -7.989  1.00 27.95  ?  400 PHE A C   1 
ATOM   2888 O  O   . PHE A 1 400 ? -8.860  -25.328 -7.434  1.00 26.27  ?  400 PHE A O   1 
ATOM   2889 C  CB  . PHE A 1 400 ? -6.774  -27.699 -6.674  1.00 27.54  ?  400 PHE A CB  1 
ATOM   2890 C  CG  . PHE A 1 400 ? -7.033  -29.157 -6.981  1.00 28.71  ?  400 PHE A CG  1 
ATOM   2891 C  CD1 . PHE A 1 400 ? -6.290  -29.832 -7.943  1.00 26.92  ?  400 PHE A CD1 1 
ATOM   2892 C  CD2 . PHE A 1 400 ? -8.008  -29.856 -6.280  1.00 27.61  ?  400 PHE A CD2 1 
ATOM   2893 C  CE1 . PHE A 1 400 ? -6.543  -31.181 -8.215  1.00 27.55  ?  400 PHE A CE1 1 
ATOM   2894 C  CE2 . PHE A 1 400 ? -8.261  -31.203 -6.544  1.00 27.64  ?  400 PHE A CE2 1 
ATOM   2895 C  CZ  . PHE A 1 400 ? -7.514  -31.871 -7.500  1.00 24.49  ?  400 PHE A CZ  1 
ATOM   2896 N  N   . ILE A 1 401 ? -9.226  -27.149 -8.713  1.00 24.91  ?  401 ILE A N   1 
ATOM   2897 C  CA  . ILE A 1 401 ? -10.656 -26.844 -8.848  1.00 28.97  ?  401 ILE A CA  1 
ATOM   2898 C  C   . ILE A 1 401 ? -11.344 -26.891 -7.491  1.00 27.68  ?  401 ILE A C   1 
ATOM   2899 O  O   . ILE A 1 401 ? -12.221 -26.072 -7.194  1.00 28.51  ?  401 ILE A O   1 
ATOM   2900 C  CB  . ILE A 1 401 ? -11.320 -27.803 -9.856  1.00 28.41  ?  401 ILE A CB  1 
ATOM   2901 C  CG1 . ILE A 1 401 ? -10.830 -27.482 -11.272 1.00 32.83  ?  401 ILE A CG1 1 
ATOM   2902 C  CG2 . ILE A 1 401 ? -12.865 -27.678 -9.812  1.00 31.79  ?  401 ILE A CG2 1 
ATOM   2903 C  CD1 . ILE A 1 401 ? -11.458 -28.353 -12.363 1.00 33.05  ?  401 ILE A CD1 1 
ATOM   2904 N  N   . LYS A 1 402 ? -10.943 -27.824 -6.629  1.00 27.92  ?  402 LYS A N   1 
ATOM   2905 C  CA  . LYS A 1 402 ? -11.523 -27.914 -5.298  1.00 25.81  ?  402 LYS A CA  1 
ATOM   2906 C  C   . LYS A 1 402 ? -10.670 -27.158 -4.289  1.00 28.01  ?  402 LYS A C   1 
ATOM   2907 O  O   . LYS A 1 402 ? -9.453  -27.031 -4.444  1.00 25.71  ?  402 LYS A O   1 
ATOM   2908 C  CB  . LYS A 1 402 ? -11.656 -29.375 -4.836  1.00 26.81  ?  402 LYS A CB  1 
ATOM   2909 C  CG  . LYS A 1 402 ? -12.488 -30.247 -5.760  1.00 28.57  ?  402 LYS A CG  1 
ATOM   2910 C  CD  . LYS A 1 402 ? -13.960 -29.808 -5.751  1.00 27.00  ?  402 LYS A CD  1 
ATOM   2911 C  CE  . LYS A 1 402 ? -14.803 -30.714 -6.620  1.00 33.70  ?  402 LYS A CE  1 
ATOM   2912 N  NZ  . LYS A 1 402 ? -16.236 -30.258 -6.588  1.00 29.94  ?  402 LYS A NZ  1 
ATOM   2913 N  N   . ARG A 1 403 ? -11.328 -26.664 -3.245  1.00 27.10  ?  403 ARG A N   1 
ATOM   2914 C  CA  . ARG A 1 403 ? -10.658 -26.255 -2.020  1.00 26.26  ?  403 ARG A CA  1 
ATOM   2915 C  C   . ARG A 1 403 ? -10.516 -27.480 -1.129  1.00 28.53  ?  403 ARG A C   1 
ATOM   2916 O  O   . ARG A 1 403 ? -11.504 -28.186 -0.885  1.00 28.69  ?  403 ARG A O   1 
ATOM   2917 C  CB  . ARG A 1 403 ? -11.485 -25.215 -1.268  1.00 29.06  ?  403 ARG A CB  1 
ATOM   2918 C  CG  . ARG A 1 403 ? -11.484 -23.819 -1.833  1.00 25.31  ?  403 ARG A CG  1 
ATOM   2919 C  CD  . ARG A 1 403 ? -12.006 -22.871 -0.757  1.00 27.57  ?  403 ARG A CD  1 
ATOM   2920 N  NE  . ARG A 1 403 ? -12.233 -21.535 -1.298  1.00 27.21  ?  403 ARG A NE  1 
ATOM   2921 C  CZ  . ARG A 1 403 ? -13.357 -21.148 -1.885  1.00 33.23  ?  403 ARG A CZ  1 
ATOM   2922 N  NH1 . ARG A 1 403 ? -14.368 -21.990 -2.068  1.00 29.44  ?  403 ARG A NH1 1 
ATOM   2923 N  NH2 . ARG A 1 403 ? -13.477 -19.883 -2.283  1.00 32.72  ?  403 ARG A NH2 1 
ATOM   2924 N  N   . LEU A 1 404 ? -9.319  -27.716 -0.606  1.00 24.58  ?  404 LEU A N   1 
ATOM   2925 C  CA  . LEU A 1 404 ? -9.205  -28.831 0.321   1.00 31.21  ?  404 LEU A CA  1 
ATOM   2926 C  C   . LEU A 1 404 ? -7.943  -28.653 1.142   1.00 28.31  ?  404 LEU A C   1 
ATOM   2927 O  O   . LEU A 1 404 ? -7.000  -28.004 0.681   1.00 26.72  ?  404 LEU A O   1 
ATOM   2928 C  CB  . LEU A 1 404 ? -9.183  -30.171 -0.429  1.00 30.82  ?  404 LEU A CB  1 
ATOM   2929 C  CG  . LEU A 1 404 ? -10.457 -30.529 -1.179  1.00 32.43  ?  404 LEU A CG  1 
ATOM   2930 C  CD1 . LEU A 1 404 ? -10.217 -31.794 -1.977  1.00 38.55  ?  404 LEU A CD1 1 
ATOM   2931 C  CD2 . LEU A 1 404 ? -11.583 -30.788 -0.208  1.00 32.94  ?  404 LEU A CD2 1 
ATOM   2932 N  N   . PRO A 1 405 ? -7.918  -29.159 2.372   1.00 26.54  ?  405 PRO A N   1 
ATOM   2933 C  CA  . PRO A 1 405 ? -6.665  -29.182 3.136   1.00 25.32  ?  405 PRO A CA  1 
ATOM   2934 C  C   . PRO A 1 405 ? -5.742  -30.258 2.572   1.00 29.26  ?  405 PRO A C   1 
ATOM   2935 O  O   . PRO A 1 405 ? -6.190  -31.358 2.236   1.00 30.15  ?  405 PRO A O   1 
ATOM   2936 C  CB  . PRO A 1 405 ? -7.129  -29.521 4.556   1.00 25.43  ?  405 PRO A CB  1 
ATOM   2937 C  CG  . PRO A 1 405 ? -8.355  -30.375 4.346   1.00 29.09  ?  405 PRO A CG  1 
ATOM   2938 C  CD  . PRO A 1 405 ? -9.015  -29.865 3.057   1.00 27.62  ?  405 PRO A CD  1 
ATOM   2939 N  N   . GLU A 1 406 ? -4.450  -29.926 2.436   1.00 26.21  ?  406 GLU A N   1 
ATOM   2940 C  CA  . GLU A 1 406 ? -3.497  -30.911 1.908   1.00 28.02  ?  406 GLU A CA  1 
ATOM   2941 C  C   . GLU A 1 406 ? -3.412  -32.123 2.821   1.00 29.72  ?  406 GLU A C   1 
ATOM   2942 O  O   . GLU A 1 406 ? -3.235  -33.261 2.357   1.00 27.53  ?  406 GLU A O   1 
ATOM   2943 C  CB  . GLU A 1 406 ? -2.105  -30.287 1.736   1.00 29.59  ?  406 GLU A CB  1 
ATOM   2944 C  CG  . GLU A 1 406 ? -2.038  -29.033 0.824   1.00 32.57  ?  406 GLU A CG  1 
ATOM   2945 C  CD  . GLU A 1 406 ? -1.924  -29.377 -0.670  1.00 33.80  ?  406 GLU A CD  1 
ATOM   2946 O  OE1 . GLU A 1 406 ? -1.425  -28.518 -1.434  1.00 28.41  ?  406 GLU A OE1 1 
ATOM   2947 O  OE2 . GLU A 1 406 ? -2.341  -30.490 -1.077  1.00 34.21  ?  406 GLU A OE2 1 
ATOM   2948 N  N   . ARG A 1 407 ? -3.521  -31.879 4.125   1.00 25.31  ?  407 ARG A N   1 
ATOM   2949 C  CA  . ARG A 1 407 ? -3.569  -32.868 5.184   1.00 27.66  ?  407 ARG A CA  1 
ATOM   2950 C  C   . ARG A 1 407 ? -4.637  -32.410 6.160   1.00 29.64  ?  407 ARG A C   1 
ATOM   2951 O  O   . ARG A 1 407 ? -4.841  -31.201 6.348   1.00 26.87  ?  407 ARG A O   1 
ATOM   2952 C  CB  . ARG A 1 407 ? -2.217  -32.986 5.918   1.00 26.89  ?  407 ARG A CB  1 
ATOM   2953 C  CG  . ARG A 1 407 ? -1.074  -33.575 5.079   1.00 28.75  ?  407 ARG A CG  1 
ATOM   2954 C  CD  . ARG A 1 407 ? 0.297   -33.073 5.569   1.00 28.49  ?  407 ARG A CD  1 
ATOM   2955 N  NE  . ARG A 1 407 ? 0.439   -31.630 5.370   1.00 30.34  ?  407 ARG A NE  1 
ATOM   2956 C  CZ  . ARG A 1 407 ? 0.753   -31.058 4.212   1.00 32.17  ?  407 ARG A CZ  1 
ATOM   2957 N  NH1 . ARG A 1 407 ? 0.989   -31.777 3.123   1.00 27.95  ?  407 ARG A NH1 1 
ATOM   2958 N  NH2 . ARG A 1 407 ? 0.843   -29.729 4.145   1.00 28.63  ?  407 ARG A NH2 1 
ATOM   2959 N  N   . LEU A 1 408 ? -5.324  -33.375 6.781   1.00 28.02  ?  408 LEU A N   1 
ATOM   2960 C  CA  . LEU A 1 408 ? -6.386  -33.093 7.749   1.00 28.48  ?  408 LEU A CA  1 
ATOM   2961 C  C   . LEU A 1 408 ? -6.024  -33.780 9.060   1.00 28.42  ?  408 LEU A C   1 
ATOM   2962 O  O   . LEU A 1 408 ? -6.592  -34.827 9.396   1.00 27.82  ?  408 LEU A O   1 
ATOM   2963 C  CB  . LEU A 1 408 ? -7.743  -33.587 7.247   1.00 27.29  ?  408 LEU A CB  1 
ATOM   2964 C  CG  . LEU A 1 408 ? -8.980  -33.183 8.052   1.00 29.07  ?  408 LEU A CG  1 
ATOM   2965 C  CD1 . LEU A 1 408 ? -8.824  -31.750 8.595   1.00 30.25  ?  408 LEU A CD1 1 
ATOM   2966 C  CD2 . LEU A 1 408 ? -10.219 -33.322 7.180   1.00 30.11  ?  408 LEU A CD2 1 
ATOM   2967 N  N   . PRO A 1 409 ? -5.090  -33.220 9.829   1.00 28.41  ?  409 PRO A N   1 
ATOM   2968 C  CA  . PRO A 1 409 ? -4.626  -33.898 11.051  1.00 29.43  ?  409 PRO A CA  1 
ATOM   2969 C  C   . PRO A 1 409 ? -5.602  -33.679 12.200  1.00 29.69  ?  409 PRO A C   1 
ATOM   2970 O  O   . PRO A 1 409 ? -6.012  -32.548 12.485  1.00 27.79  ?  409 PRO A O   1 
ATOM   2971 C  CB  . PRO A 1 409 ? -3.262  -33.248 11.333  1.00 29.02  ?  409 PRO A CB  1 
ATOM   2972 C  CG  . PRO A 1 409 ? -3.180  -32.046 10.476  1.00 28.48  ?  409 PRO A CG  1 
ATOM   2973 C  CD  . PRO A 1 409 ? -4.396  -31.941 9.597   1.00 30.95  ?  409 PRO A CD  1 
ATOM   2974 N  N   . VAL A 1 410 ? -5.995  -34.777 12.844  1.00 27.10  ?  410 VAL A N   1 
ATOM   2975 C  CA  . VAL A 1 410 ? -7.025  -34.749 13.875  1.00 26.14  ?  410 VAL A CA  1 
ATOM   2976 C  C   . VAL A 1 410 ? -6.547  -35.564 15.069  1.00 30.96  ?  410 VAL A C   1 
ATOM   2977 O  O   . VAL A 1 410 ? -5.647  -36.400 14.970  1.00 27.64  ?  410 VAL A O   1 
ATOM   2978 C  CB  . VAL A 1 410 ? -8.387  -35.303 13.376  1.00 27.52  ?  410 VAL A CB  1 
ATOM   2979 C  CG1 . VAL A 1 410 ? -8.879  -34.536 12.146  1.00 26.60  ?  410 VAL A CG1 1 
ATOM   2980 C  CG2 . VAL A 1 410 ? -8.273  -36.784 13.055  1.00 27.02  ?  410 VAL A CG2 1 
ATOM   2981 N  N   . LEU A 1 411 ? -7.159  -35.290 16.210  1.00 27.47  ?  411 LEU A N   1 
ATOM   2982 C  CA  . LEU A 1 411 ? -6.998  -36.073 17.421  1.00 29.91  ?  411 LEU A CA  1 
ATOM   2983 C  C   . LEU A 1 411 ? -8.356  -36.640 17.788  1.00 31.88  ?  411 LEU A C   1 
ATOM   2984 O  O   . LEU A 1 411 ? -9.387  -36.173 17.299  1.00 29.74  ?  411 LEU A O   1 
ATOM   2985 C  CB  . LEU A 1 411 ? -6.476  -35.222 18.586  1.00 30.57  ?  411 LEU A CB  1 
ATOM   2986 C  CG  . LEU A 1 411 ? -5.113  -34.580 18.381  1.00 30.66  ?  411 LEU A CG  1 
ATOM   2987 C  CD1 . LEU A 1 411 ? -4.902  -33.542 19.460  1.00 34.61  ?  411 LEU A CD1 1 
ATOM   2988 C  CD2 . LEU A 1 411 ? -4.034  -35.650 18.429  1.00 31.86  ?  411 LEU A CD2 1 
ATOM   2989 N  N   . TRP A 1 412 ? -8.353  -37.629 18.683  1.00 30.12  ?  412 TRP A N   1 
ATOM   2990 C  CA  . TRP A 1 412 ? -9.611  -38.176 19.200  1.00 32.28  ?  412 TRP A CA  1 
ATOM   2991 C  C   . TRP A 1 412 ? -9.312  -38.929 20.499  1.00 37.23  ?  412 TRP A C   1 
ATOM   2992 O  O   . TRP A 1 412 ? -8.124  -38.992 20.877  1.00 36.69  ?  412 TRP A O   1 
ATOM   2993 C  CB  . TRP A 1 412 ? -10.277 -39.092 18.178  1.00 30.76  ?  412 TRP A CB  1 
ATOM   2994 C  CG  . TRP A 1 412 ? -9.449  -40.302 17.890  1.00 32.86  ?  412 TRP A CG  1 
ATOM   2995 C  CD1 . TRP A 1 412 ? -9.425  -41.471 18.603  1.00 35.74  ?  412 TRP A CD1 1 
ATOM   2996 C  CD2 . TRP A 1 412 ? -8.524  -40.468 16.815  1.00 33.45  ?  412 TRP A CD2 1 
ATOM   2997 N  NE1 . TRP A 1 412 ? -8.533  -42.354 18.038  1.00 33.82  ?  412 TRP A NE1 1 
ATOM   2998 C  CE2 . TRP A 1 412 ? -7.966  -41.763 16.938  1.00 35.72  ?  412 TRP A CE2 1 
ATOM   2999 C  CE3 . TRP A 1 412 ? -8.108  -39.651 15.759  1.00 33.64  ?  412 TRP A CE3 1 
ATOM   3000 C  CZ2 . TRP A 1 412 ? -7.012  -42.249 16.050  1.00 31.93  ?  412 TRP A CZ2 1 
ATOM   3001 C  CZ3 . TRP A 1 412 ? -7.165  -40.147 14.870  1.00 32.45  ?  412 TRP A CZ3 1 
ATOM   3002 C  CH2 . TRP A 1 412 ? -6.634  -41.429 15.017  1.00 33.56  ?  412 TRP A CH2 1 
HETATM 3003 N  N   . UYM B 2 .   ? -12.494 -34.895 -15.238 1.00 37.04  ?  501 UYM A N   1 
HETATM 3004 C  C   . UYM B 2 .   ? -18.081 -33.657 -16.604 1.00 42.57  ?  501 UYM A C   1 
HETATM 3005 O  O   . UYM B 2 .   ? -18.527 -34.813 -16.575 1.00 41.96  ?  501 UYM A O   1 
HETATM 3006 C  C1  . UYM B 2 .   ? -16.585 -33.451 -16.515 1.00 38.96  ?  501 UYM A C1  1 
HETATM 3007 C  C10 . UYM B 2 .   ? -11.152 -32.778 -15.079 1.00 34.31  ?  501 UYM A C10 1 
HETATM 3008 C  C11 . UYM B 2 .   ? -18.432 -31.194 -16.572 1.00 38.03  ?  501 UYM A C11 1 
HETATM 3009 C  C12 . UYM B 2 .   ? -18.938 -30.616 -15.227 1.00 36.03  ?  501 UYM A C12 1 
HETATM 3010 C  C15 . UYM B 2 .   ? -16.935 -31.002 -16.728 1.00 38.73  ?  501 UYM A C15 1 
HETATM 3011 C  C2  . UYM B 2 .   ? -16.052 -33.911 -15.135 1.00 36.39  ?  501 UYM A C2  1 
HETATM 3012 C  C3  . UYM B 2 .   ? -14.558 -34.025 -15.138 1.00 36.20  ?  501 UYM A C3  1 
HETATM 3013 C  C34 . UYM B 2 .   ? -18.354 -31.227 -13.984 1.00 37.20  ?  501 UYM A C34 1 
HETATM 3014 C  C35 . UYM B 2 .   ? -18.837 -32.323 -13.323 1.00 37.60  ?  501 UYM A C35 1 
HETATM 3015 C  C37 . UYM B 2 .   ? -17.043 -31.675 -12.149 1.00 35.23  ?  501 UYM A C37 1 
HETATM 3016 C  C38 . UYM B 2 .   ? -17.196 -30.786 -13.236 1.00 36.84  ?  501 UYM A C38 1 
HETATM 3017 C  C39 . UYM B 2 .   ? -16.279 -29.737 -13.383 1.00 36.20  ?  501 UYM A C39 1 
HETATM 3018 C  C4  . UYM B 2 .   ? -13.837 -35.182 -15.240 1.00 35.57  ?  501 UYM A C4  1 
HETATM 3019 C  C40 . UYM B 2 .   ? -15.261 -29.605 -12.461 1.00 34.46  ?  501 UYM A C40 1 
HETATM 3020 C  C41 . UYM B 2 .   ? -15.136 -30.493 -11.389 1.00 34.51  ?  501 UYM A C41 1 
HETATM 3021 C  C42 . UYM B 2 .   ? -16.021 -31.534 -11.209 1.00 33.76  ?  501 UYM A C42 1 
HETATM 3022 C  C5  . UYM B 2 .   ? -12.320 -33.535 -15.138 1.00 36.53  ?  501 UYM A C5  1 
HETATM 3023 C  C6  . UYM B 2 .   ? -13.601 -32.947 -15.070 1.00 35.26  ?  501 UYM A C6  1 
HETATM 3024 C  C7  . UYM B 2 .   ? -13.708 -31.555 -14.961 1.00 37.69  ?  501 UYM A C7  1 
HETATM 3025 C  C8  . UYM B 2 .   ? -12.552 -30.808 -14.908 1.00 37.10  ?  501 UYM A C8  1 
HETATM 3026 C  C9  . UYM B 2 .   ? -11.295 -31.413 -14.964 1.00 39.23  ?  501 UYM A C9  1 
HETATM 3027 N  N1  . UYM B 2 .   ? -16.168 -32.083 -16.799 1.00 35.94  ?  501 UYM A N1  1 
HETATM 3028 N  N2  . UYM B 2 .   ? -18.858 -32.583 -16.700 1.00 39.60  ?  501 UYM A N2  1 
HETATM 3029 N  N36 . UYM B 2 .   ? -18.055 -32.598 -12.230 1.00 36.90  ?  501 UYM A N36 1 
HETATM 3030 O  O1  . UYM B 2 .   ? -16.472 -29.853 -16.800 1.00 39.55  ?  501 UYM A O1  1 
HETATM 3031 N  N9  . GUN C 3 .   ? -19.165 -29.980 -10.733 1.00 34.57  ?  502 GUN A N9  1 
HETATM 3032 C  C8  . GUN C 3 .   ? -18.988 -30.676 -9.619  1.00 34.19  ?  502 GUN A C8  1 
HETATM 3033 N  N7  . GUN C 3 .   ? -18.092 -30.137 -8.777  1.00 30.69  ?  502 GUN A N7  1 
HETATM 3034 C  C5  . GUN C 3 .   ? -17.634 -28.988 -9.379  1.00 30.25  ?  502 GUN A C5  1 
HETATM 3035 C  C6  . GUN C 3 .   ? -16.694 -27.974 -9.019  1.00 30.03  ?  502 GUN A C6  1 
HETATM 3036 O  O6  . GUN C 3 .   ? -16.027 -27.906 -7.984  1.00 29.88  ?  502 GUN A O6  1 
HETATM 3037 N  N1  . GUN C 3 .   ? -16.559 -26.991 -9.992  1.00 29.50  ?  502 GUN A N1  1 
HETATM 3038 C  C2  . GUN C 3 .   ? -17.261 -26.966 -11.167 1.00 30.72  ?  502 GUN A C2  1 
HETATM 3039 N  N2  . GUN C 3 .   ? -17.007 -25.940 -11.993 1.00 29.32  ?  502 GUN A N2  1 
HETATM 3040 N  N3  . GUN C 3 .   ? -18.136 -27.903 -11.493 1.00 31.80  ?  502 GUN A N3  1 
HETATM 3041 C  C4  . GUN C 3 .   ? -18.318 -28.905 -10.605 1.00 31.90  ?  502 GUN A C4  1 
HETATM 3042 C  CHA . HEM D 4 .   ? -22.365 -31.938 -12.006 1.00 34.59  ?  503 HEM A CHA 1 
HETATM 3043 C  CHB . HEM D 4 .   ? -21.557 -31.074 -7.291  1.00 29.53  ?  503 HEM A CHB 1 
HETATM 3044 C  CHC . HEM D 4 .   ? -20.626 -35.791 -6.612  1.00 27.56  ?  503 HEM A CHC 1 
HETATM 3045 C  CHD . HEM D 4 .   ? -20.867 -36.525 -11.430 1.00 33.16  ?  503 HEM A CHD 1 
HETATM 3046 C  C1A . HEM D 4 .   ? -22.302 -31.285 -10.774 1.00 35.92  ?  503 HEM A C1A 1 
HETATM 3047 C  C2A . HEM D 4 .   ? -22.548 -29.874 -10.546 1.00 32.91  ?  503 HEM A C2A 1 
HETATM 3048 C  C3A . HEM D 4 .   ? -22.227 -29.618 -9.245  1.00 32.47  ?  503 HEM A C3A 1 
HETATM 3049 C  C4A . HEM D 4 .   ? -21.907 -30.885 -8.628  1.00 33.32  ?  503 HEM A C4A 1 
HETATM 3050 C  CMA . HEM D 4 .   ? -22.198 -28.273 -8.578  1.00 30.61  ?  503 HEM A CMA 1 
HETATM 3051 C  CAA . HEM D 4 .   ? -23.034 -28.897 -11.576 1.00 30.62  ?  503 HEM A CAA 1 
HETATM 3052 C  CBA . HEM D 4 .   ? -21.921 -28.340 -12.472 1.00 29.90  ?  503 HEM A CBA 1 
HETATM 3053 C  CGA . HEM D 4 .   ? -22.389 -27.251 -13.422 1.00 35.26  ?  503 HEM A CGA 1 
HETATM 3054 O  O1A . HEM D 4 .   ? -23.591 -26.918 -13.375 1.00 33.07  ?  503 HEM A O1A 1 
HETATM 3055 O  O2A . HEM D 4 .   ? -21.550 -26.728 -14.193 1.00 33.76  -1 503 HEM A O2A 1 
HETATM 3056 C  C1B . HEM D 4 .   ? -21.177 -32.256 -6.661  1.00 30.91  ?  503 HEM A C1B 1 
HETATM 3057 C  C2B . HEM D 4 .   ? -20.890 -32.409 -5.246  1.00 30.58  ?  503 HEM A C2B 1 
HETATM 3058 C  C3B . HEM D 4 .   ? -20.684 -33.815 -5.075  1.00 28.76  ?  503 HEM A C3B 1 
HETATM 3059 C  C4B . HEM D 4 .   ? -20.765 -34.422 -6.322  1.00 30.92  ?  503 HEM A C4B 1 
HETATM 3060 C  CMB . HEM D 4 .   ? -20.848 -31.312 -4.220  1.00 30.48  ?  503 HEM A CMB 1 
HETATM 3061 C  CAB . HEM D 4 .   ? -20.456 -34.580 -3.913  1.00 31.41  ?  503 HEM A CAB 1 
HETATM 3062 C  CBB . HEM D 4 .   ? -20.536 -34.219 -2.661  1.00 35.42  ?  503 HEM A CBB 1 
HETATM 3063 C  C1C . HEM D 4 .   ? -20.655 -36.443 -7.839  1.00 28.86  ?  503 HEM A C1C 1 
HETATM 3064 C  C2C . HEM D 4 .   ? -20.497 -37.874 -8.040  1.00 31.74  ?  503 HEM A C2C 1 
HETATM 3065 C  C3C . HEM D 4 .   ? -20.416 -38.029 -9.464  1.00 32.08  ?  503 HEM A C3C 1 
HETATM 3066 C  C4C . HEM D 4 .   ? -20.706 -36.802 -10.048 1.00 29.58  ?  503 HEM A C4C 1 
HETATM 3067 C  CMC . HEM D 4 .   ? -20.414 -38.925 -6.969  1.00 29.39  ?  503 HEM A CMC 1 
HETATM 3068 C  CAC . HEM D 4 .   ? -20.138 -39.160 -10.248 1.00 34.90  ?  503 HEM A CAC 1 
HETATM 3069 C  CBC . HEM D 4 .   ? -19.896 -40.376 -9.849  1.00 38.19  ?  503 HEM A CBC 1 
HETATM 3070 C  C1D . HEM D 4 .   ? -21.276 -35.337 -12.035 1.00 32.68  ?  503 HEM A C1D 1 
HETATM 3071 C  C2D . HEM D 4 .   ? -21.520 -35.140 -13.448 1.00 34.67  ?  503 HEM A C2D 1 
HETATM 3072 C  C3D . HEM D 4 .   ? -21.953 -33.852 -13.608 1.00 35.28  ?  503 HEM A C3D 1 
HETATM 3073 C  C4D . HEM D 4 .   ? -21.977 -33.248 -12.291 1.00 34.02  ?  503 HEM A C4D 1 
HETATM 3074 C  CMD . HEM D 4 .   ? -21.324 -36.170 -14.523 1.00 34.01  ?  503 HEM A CMD 1 
HETATM 3075 C  CAD . HEM D 4 .   ? -22.334 -33.144 -14.875 1.00 38.09  ?  503 HEM A CAD 1 
HETATM 3076 C  CBD . HEM D 4 .   ? -23.852 -33.131 -15.115 1.00 38.86  ?  503 HEM A CBD 1 
HETATM 3077 C  CGD . HEM D 4 .   ? -24.288 -32.460 -16.408 1.00 43.84  ?  503 HEM A CGD 1 
HETATM 3078 O  O1D . HEM D 4 .   ? -23.434 -31.853 -17.082 1.00 42.05  ?  503 HEM A O1D 1 
HETATM 3079 O  O2D . HEM D 4 .   ? -25.491 -32.554 -16.739 1.00 47.46  -1 503 HEM A O2D 1 
HETATM 3080 N  NA  . HEM D 4 .   ? -21.953 -31.882 -9.588  1.00 30.38  ?  503 HEM A NA  1 
HETATM 3081 N  NB  . HEM D 4 .   ? -20.994 -33.463 -7.279  1.00 29.14  ?  503 HEM A NB  1 
HETATM 3082 N  NC  . HEM D 4 .   ? -20.820 -35.840 -9.059  1.00 29.22  ?  503 HEM A NC  1 
HETATM 3083 N  ND  . HEM D 4 .   ? -21.530 -34.165 -11.365 1.00 33.17  ?  503 HEM A ND  1 
HETATM 3084 FE FE  . HEM D 4 .   ? -21.717 -33.893 -9.258  1.00 33.52  ?  503 HEM A FE  1 
HETATM 3085 O  O   . HOH E 5 .   ? -22.985 -14.203 3.290   1.00 38.45  ?  601 HOH A O   1 
HETATM 3086 O  O   . HOH E 5 .   ? -1.645  -43.582 12.042  1.00 39.65  ?  602 HOH A O   1 
HETATM 3087 O  O   . HOH E 5 .   ? -27.145 -47.589 -22.041 1.00 61.58  ?  603 HOH A O   1 
HETATM 3088 O  O   . HOH E 5 .   ? -31.234 -42.575 -6.577  1.00 64.15  ?  604 HOH A O   1 
HETATM 3089 O  O   . HOH E 5 .   ? -12.839 -21.283 10.960  1.00 49.89  ?  605 HOH A O   1 
HETATM 3090 O  O   . HOH E 5 .   ? -11.423 -55.519 -16.161 1.00 47.76  ?  606 HOH A O   1 
HETATM 3091 O  O   . HOH E 5 .   ? -21.508 -32.705 -18.242 1.00 48.38  ?  607 HOH A O   1 
HETATM 3092 O  O   . HOH E 5 .   ? -32.094 -29.164 0.418   1.00 46.64  ?  608 HOH A O   1 
HETATM 3093 O  O   . HOH E 5 .   ? -11.480 -24.787 -18.366 1.00 40.94  ?  609 HOH A O   1 
HETATM 3094 O  O   . HOH E 5 .   ? -23.337 -45.195 13.892  1.00 46.70  ?  610 HOH A O   1 
HETATM 3095 O  O   . HOH E 5 .   ? -14.153 -52.656 -6.784  1.00 45.74  ?  611 HOH A O   1 
HETATM 3096 O  O   . HOH E 5 .   ? -29.080 -10.977 -1.052  1.00 48.26  ?  612 HOH A O   1 
HETATM 3097 O  O   . HOH E 5 .   ? -6.871  -11.890 -11.897 1.00 38.59  ?  613 HOH A O   1 
HETATM 3098 O  O   . HOH E 5 .   ? -3.349  -36.957 -3.557  1.00 51.61  ?  614 HOH A O   1 
HETATM 3099 O  O   . HOH E 5 .   ? -15.920 -51.851 13.755  1.00 52.23  ?  615 HOH A O   1 
HETATM 3100 O  O   . HOH E 5 .   ? -25.618 -42.874 18.370  1.00 43.98  ?  616 HOH A O   1 
HETATM 3101 O  O   . HOH E 5 .   ? -3.017  -35.923 2.832   1.00 29.96  ?  617 HOH A O   1 
HETATM 3102 O  O   . HOH E 5 .   ? -17.209 -16.477 -26.907 1.00 49.84  ?  618 HOH A O   1 
HETATM 3103 O  O   . HOH E 5 .   ? -26.015 -25.815 -20.486 1.00 41.04  ?  619 HOH A O   1 
HETATM 3104 O  O   . HOH E 5 .   ? -34.155 -19.993 -21.263 1.00 56.39  ?  620 HOH A O   1 
HETATM 3105 O  O   . HOH E 5 .   ? -31.003 -15.485 11.718  1.00 39.75  ?  621 HOH A O   1 
HETATM 3106 O  O   . HOH E 5 .   ? -4.993  -39.904 -2.427  1.00 41.38  ?  622 HOH A O   1 
HETATM 3107 O  O   . HOH E 5 .   ? -7.643  -52.540 11.518  1.00 53.97  ?  623 HOH A O   1 
HETATM 3108 O  O   . HOH E 5 .   ? -10.008 -18.091 -12.762 1.00 33.29  ?  624 HOH A O   1 
HETATM 3109 O  O   . HOH E 5 .   ? -2.204  -46.003 -19.780 1.00 43.34  ?  625 HOH A O   1 
HETATM 3110 O  O   . HOH E 5 .   ? -29.289 -36.326 -8.921  1.00 38.13  ?  626 HOH A O   1 
HETATM 3111 O  O   . HOH E 5 .   ? -26.992 -40.598 -7.282  1.00 38.82  ?  627 HOH A O   1 
HETATM 3112 O  O   . HOH E 5 .   ? -13.582 -23.269 12.113  1.00 44.93  ?  628 HOH A O   1 
HETATM 3113 O  O   . HOH E 5 .   ? -17.873 -22.964 -2.873  1.00 37.88  ?  629 HOH A O   1 
HETATM 3114 O  O   . HOH E 5 .   ? -6.412  -25.658 -15.892 1.00 30.98  ?  630 HOH A O   1 
HETATM 3115 O  O   . HOH E 5 .   ? -7.552  -40.743 -12.622 1.00 36.60  ?  631 HOH A O   1 
HETATM 3116 O  O   . HOH E 5 .   ? -13.648 -52.831 10.521  1.00 43.53  ?  632 HOH A O   1 
HETATM 3117 O  O   . HOH E 5 .   ? -16.447 -12.831 -20.778 1.00 41.35  ?  633 HOH A O   1 
HETATM 3118 O  O   . HOH E 5 .   ? -25.985 -27.115 -12.301 1.00 37.56  ?  634 HOH A O   1 
HETATM 3119 O  O   . HOH E 5 .   ? -23.851 -40.032 -30.114 1.00 65.26  ?  635 HOH A O   1 
HETATM 3120 O  O   . HOH E 5 .   ? -1.746  -30.920 -22.372 1.00 36.34  ?  636 HOH A O   1 
HETATM 3121 O  O   . HOH E 5 .   ? -3.408  -39.136 -0.299  1.00 45.81  ?  637 HOH A O   1 
HETATM 3122 O  O   . HOH E 5 .   ? -21.773 -46.681 11.162  1.00 38.59  ?  638 HOH A O   1 
HETATM 3123 O  O   . HOH E 5 .   ? -18.121 -29.338 -24.572 1.00 43.31  ?  639 HOH A O   1 
HETATM 3124 O  O   . HOH E 5 .   ? -27.130 -22.792 -17.557 1.00 39.38  ?  640 HOH A O   1 
HETATM 3125 O  O   . HOH E 5 .   ? -11.428 -38.834 -24.316 1.00 48.39  ?  641 HOH A O   1 
HETATM 3126 O  O   . HOH E 5 .   ? -2.943  -41.769 -12.680 1.00 32.70  ?  642 HOH A O   1 
HETATM 3127 O  O   . HOH E 5 .   ? -22.346 -25.553 -1.564  1.00 42.68  ?  643 HOH A O   1 
HETATM 3128 O  O   . HOH E 5 .   ? -28.603 -35.644 2.654   1.00 36.45  ?  644 HOH A O   1 
HETATM 3129 O  O   . HOH E 5 .   ? -0.318  -40.637 -21.777 1.00 34.93  ?  645 HOH A O   1 
HETATM 3130 O  O   . HOH E 5 .   ? -18.932 -27.298 -14.145 1.00 33.82  ?  646 HOH A O   1 
HETATM 3131 O  O   . HOH E 5 .   ? -17.125 -53.536 -4.206  1.00 50.55  ?  647 HOH A O   1 
HETATM 3132 O  O   . HOH E 5 .   ? -0.840  -38.239 5.069   1.00 36.88  ?  648 HOH A O   1 
HETATM 3133 O  O   . HOH E 5 .   ? -13.094 -8.194  0.137   1.00 45.59  ?  649 HOH A O   1 
HETATM 3134 O  O   . HOH E 5 .   ? -20.734 -10.924 -8.102  1.00 37.84  ?  650 HOH A O   1 
HETATM 3135 O  O   . HOH E 5 .   ? -7.339  -45.849 7.548   1.00 29.55  ?  651 HOH A O   1 
HETATM 3136 O  O   . HOH E 5 .   ? -0.203  -21.767 17.141  1.00 34.08  ?  652 HOH A O   1 
HETATM 3137 O  O   . HOH E 5 .   ? -25.527 -10.208 1.138   1.00 54.34  ?  653 HOH A O   1 
HETATM 3138 O  O   . HOH E 5 .   ? -26.430 -41.350 11.683  1.00 37.89  ?  654 HOH A O   1 
HETATM 3139 O  O   . HOH E 5 .   ? -11.483 -51.419 -0.209  1.00 56.34  ?  655 HOH A O   1 
HETATM 3140 O  O   . HOH E 5 .   ? -21.157 -22.482 11.739  1.00 32.21  ?  656 HOH A O   1 
HETATM 3141 O  O   . HOH E 5 .   ? -7.426  -49.754 -8.974  1.00 48.80  ?  657 HOH A O   1 
HETATM 3142 O  O   . HOH E 5 .   ? -32.572 -36.433 8.416   1.00 41.32  ?  658 HOH A O   1 
HETATM 3143 O  O   . HOH E 5 .   ? -26.125 -13.645 11.126  1.00 50.88  ?  659 HOH A O   1 
HETATM 3144 O  O   . HOH E 5 .   ? -31.168 -25.446 -17.013 1.00 40.76  ?  660 HOH A O   1 
HETATM 3145 O  O   . HOH E 5 .   ? -23.338 -13.655 7.632   1.00 40.38  ?  661 HOH A O   1 
HETATM 3146 O  O   . HOH E 5 .   ? -16.794 -31.159 -3.915  1.00 27.25  ?  662 HOH A O   1 
HETATM 3147 O  O   . HOH E 5 .   ? -8.016  -22.690 -8.306  1.00 32.07  ?  663 HOH A O   1 
HETATM 3148 O  O   . HOH E 5 .   ? -17.161 -24.159 11.635  1.00 46.57  ?  664 HOH A O   1 
HETATM 3149 O  O   . HOH E 5 .   ? -18.632 -21.460 -6.707  1.00 34.33  ?  665 HOH A O   1 
HETATM 3150 O  O   . HOH E 5 .   ? -0.740  -49.045 -8.833  1.00 45.21  ?  666 HOH A O   1 
HETATM 3151 O  O   . HOH E 5 .   ? -18.560 -53.305 -8.491  1.00 50.97  ?  667 HOH A O   1 
HETATM 3152 O  O   . HOH E 5 .   ? -18.109 -56.695 -24.488 1.00 64.13  ?  668 HOH A O   1 
HETATM 3153 O  O   . HOH E 5 .   ? -27.494 -24.894 -22.730 1.00 44.04  ?  669 HOH A O   1 
HETATM 3154 O  O   . HOH E 5 .   ? -22.471 -15.779 13.781  1.00 42.93  ?  670 HOH A O   1 
HETATM 3155 O  O   . HOH E 5 .   ? -0.274  -36.553 -7.010  1.00 34.97  ?  671 HOH A O   1 
HETATM 3156 O  O   . HOH E 5 .   ? -3.761  -27.962 -19.924 1.00 35.72  ?  672 HOH A O   1 
HETATM 3157 O  O   . HOH E 5 .   ? -11.996 -18.139 2.855   1.00 33.21  ?  673 HOH A O   1 
HETATM 3158 O  O   . HOH E 5 .   ? -27.124 -7.522  -3.615  1.00 49.24  ?  674 HOH A O   1 
HETATM 3159 O  O   . HOH E 5 .   ? -11.782 -6.979  -4.961  1.00 57.26  ?  675 HOH A O   1 
HETATM 3160 O  O   . HOH E 5 .   ? -7.603  -22.456 7.643   1.00 33.54  ?  676 HOH A O   1 
HETATM 3161 O  O   . HOH E 5 .   ? -35.405 -21.421 -4.024  1.00 44.19  ?  677 HOH A O   1 
HETATM 3162 O  O   . HOH E 5 .   ? -24.055 -25.136 16.540  1.00 40.90  ?  678 HOH A O   1 
HETATM 3163 O  O   . HOH E 5 .   ? -3.455  -50.650 -17.369 1.00 51.84  ?  679 HOH A O   1 
HETATM 3164 O  O   . HOH E 5 .   ? -8.404  -5.920  -8.074  1.00 56.24  ?  680 HOH A O   1 
HETATM 3165 O  O   . HOH E 5 .   ? -34.092 -17.143 -9.193  1.00 50.13  ?  681 HOH A O   1 
HETATM 3166 O  O   . HOH E 5 .   ? -3.002  -29.173 6.618   1.00 27.32  ?  682 HOH A O   1 
HETATM 3167 O  O   . HOH E 5 .   ? -14.149 -27.026 -15.300 1.00 46.20  ?  683 HOH A O   1 
HETATM 3168 O  O   . HOH E 5 .   ? -1.100  -24.577 1.479   1.00 32.34  ?  684 HOH A O   1 
HETATM 3169 O  O   . HOH E 5 .   ? -36.858 -24.736 12.637  1.00 33.39  ?  685 HOH A O   1 
HETATM 3170 O  O   . HOH E 5 .   ? -35.371 -38.104 14.498  1.00 61.76  ?  686 HOH A O   1 
HETATM 3171 O  O   . HOH E 5 .   ? -22.744 -54.688 -10.514 1.00 59.75  ?  687 HOH A O   1 
HETATM 3172 O  O   . HOH E 5 .   ? -23.500 -23.452 14.199  1.00 38.29  ?  688 HOH A O   1 
HETATM 3173 O  O   . HOH E 5 .   ? 0.742   -23.254 -22.903 1.00 41.29  ?  689 HOH A O   1 
HETATM 3174 O  O   . HOH E 5 .   ? -27.696 -49.621 -0.320  1.00 52.25  ?  690 HOH A O   1 
HETATM 3175 O  O   . HOH E 5 .   ? -31.188 -27.293 8.174   1.00 36.39  ?  691 HOH A O   1 
HETATM 3176 O  O   . HOH E 5 .   ? -17.041 -8.837  3.316   1.00 45.70  ?  692 HOH A O   1 
HETATM 3177 O  O   . HOH E 5 .   ? -3.339  -21.592 6.353   1.00 53.90  ?  693 HOH A O   1 
HETATM 3178 O  O   . HOH E 5 .   ? -25.845 -25.798 -24.578 1.00 46.05  ?  694 HOH A O   1 
HETATM 3179 O  O   . HOH E 5 .   ? -11.958 -49.689 16.536  1.00 42.22  ?  695 HOH A O   1 
HETATM 3180 O  O   . HOH E 5 .   ? -2.772  -15.671 -13.280 1.00 45.33  ?  696 HOH A O   1 
HETATM 3181 O  O   . HOH E 5 .   ? -3.475  -21.986 -22.921 1.00 41.79  ?  697 HOH A O   1 
HETATM 3182 O  O   . HOH E 5 .   ? -17.320 -34.463 19.421  1.00 39.59  ?  698 HOH A O   1 
HETATM 3183 O  O   . HOH E 5 .   ? -0.000  -26.626 0.000   0.50 30.28  ?  699 HOH A O   1 
HETATM 3184 O  O   . HOH E 5 .   ? -30.882 -13.663 -3.877  1.00 35.17  ?  700 HOH A O   1 
HETATM 3185 O  O   . HOH E 5 .   ? -26.291 -25.731 14.953  1.00 41.20  ?  701 HOH A O   1 
HETATM 3186 O  O   . HOH E 5 .   ? -15.585 -52.871 8.689   1.00 40.63  ?  702 HOH A O   1 
HETATM 3187 O  O   . HOH E 5 .   ? -15.026 -21.215 -20.740 1.00 35.85  ?  703 HOH A O   1 
HETATM 3188 O  O   . HOH E 5 .   ? -21.503 -10.685 -28.740 1.00 52.81  ?  704 HOH A O   1 
HETATM 3189 O  O   . HOH E 5 .   ? -14.063 -31.059 18.776  1.00 37.50  ?  705 HOH A O   1 
HETATM 3190 O  O   . HOH E 5 .   ? -3.077  -30.707 -7.362  1.00 33.81  ?  706 HOH A O   1 
HETATM 3191 O  O   . HOH E 5 .   ? -7.321  -41.224 22.332  1.00 44.55  ?  707 HOH A O   1 
HETATM 3192 O  O   . HOH E 5 .   ? -16.991 -27.236 -16.007 1.00 36.56  ?  708 HOH A O   1 
HETATM 3193 O  O   . HOH E 5 .   ? -11.634 -10.492 -5.683  1.00 46.72  ?  709 HOH A O   1 
HETATM 3194 O  O   . HOH E 5 .   ? -25.139 -40.997 14.147  1.00 36.29  ?  710 HOH A O   1 
HETATM 3195 O  O   . HOH E 5 .   ? -1.514  -41.902 20.262  1.00 35.08  ?  711 HOH A O   1 
HETATM 3196 O  O   . HOH E 5 .   ? -2.398  -40.485 8.977   1.00 46.90  ?  712 HOH A O   1 
HETATM 3197 O  O   . HOH E 5 .   ? -20.060 -37.083 -0.557  1.00 32.89  ?  713 HOH A O   1 
HETATM 3198 O  O   . HOH E 5 .   ? -8.954  -28.579 -14.884 1.00 39.12  ?  714 HOH A O   1 
HETATM 3199 O  O   . HOH E 5 .   ? -7.477  -24.892 -4.827  1.00 28.35  ?  715 HOH A O   1 
HETATM 3200 O  O   . HOH E 5 .   ? -29.311 -10.182 -6.460  1.00 46.42  ?  716 HOH A O   1 
HETATM 3201 O  O   . HOH E 5 .   ? 3.837   -27.551 -19.415 1.00 38.30  ?  717 HOH A O   1 
HETATM 3202 O  O   . HOH E 5 .   ? -23.056 -42.681 14.669  1.00 40.30  ?  718 HOH A O   1 
HETATM 3203 O  O   . HOH E 5 .   ? -6.610  -14.560 -10.654 1.00 42.91  ?  719 HOH A O   1 
HETATM 3204 O  O   . HOH E 5 .   ? -6.689  -36.542 -5.144  1.00 44.56  ?  720 HOH A O   1 
HETATM 3205 O  O   . HOH E 5 .   ? -35.553 -21.754 9.393   1.00 50.16  ?  721 HOH A O   1 
HETATM 3206 O  O   . HOH E 5 .   ? -6.244  -38.856 -14.980 1.00 39.76  ?  722 HOH A O   1 
HETATM 3207 O  O   . HOH E 5 .   ? -21.539 -23.167 -0.403  1.00 33.45  ?  723 HOH A O   1 
HETATM 3208 O  O   . HOH E 5 .   ? -4.093  -43.176 13.376  1.00 38.78  ?  724 HOH A O   1 
HETATM 3209 O  O   . HOH E 5 .   ? -33.877 -19.000 -15.434 1.00 42.00  ?  725 HOH A O   1 
HETATM 3210 O  O   . HOH E 5 .   ? -2.883  -48.041 -4.855  1.00 35.12  ?  726 HOH A O   1 
HETATM 3211 O  O   . HOH E 5 .   ? -3.105  -22.001 -0.897  1.00 31.66  ?  727 HOH A O   1 
HETATM 3212 O  O   . HOH E 5 .   ? -16.283 -33.800 16.985  1.00 35.44  ?  728 HOH A O   1 
HETATM 3213 O  O   . HOH E 5 .   ? -27.900 -29.517 16.328  1.00 37.78  ?  729 HOH A O   1 
HETATM 3214 O  O   . HOH E 5 .   ? -30.508 -35.695 -3.742  1.00 51.38  ?  730 HOH A O   1 
HETATM 3215 O  O   . HOH E 5 .   ? -27.641 -26.012 -15.469 1.00 37.16  ?  731 HOH A O   1 
HETATM 3216 O  O   . HOH E 5 .   ? -11.115 -28.860 16.395  1.00 31.64  ?  732 HOH A O   1 
HETATM 3217 O  O   . HOH E 5 .   ? -7.499  -7.422  -11.747 1.00 48.51  ?  733 HOH A O   1 
HETATM 3218 O  O   . HOH E 5 .   ? -24.731 -24.913 -28.218 1.00 55.02  ?  734 HOH A O   1 
HETATM 3219 O  O   . HOH E 5 .   ? -0.715  -41.713 -2.614  1.00 41.55  ?  735 HOH A O   1 
HETATM 3220 O  O   . HOH E 5 .   ? -1.710  -24.142 -11.260 1.00 35.62  ?  736 HOH A O   1 
HETATM 3221 O  O   . HOH E 5 .   ? -15.022 -20.502 -5.382  1.00 38.52  ?  737 HOH A O   1 
HETATM 3222 O  O   . HOH E 5 .   ? -35.644 -33.385 15.021  1.00 56.46  ?  738 HOH A O   1 
HETATM 3223 O  O   . HOH E 5 .   ? -5.059  -43.574 -24.182 1.00 44.03  ?  739 HOH A O   1 
HETATM 3224 O  O   . HOH E 5 .   ? -9.479  -36.324 -4.641  1.00 39.66  ?  740 HOH A O   1 
HETATM 3225 O  O   . HOH E 5 .   ? -5.663  -34.497 -17.133 1.00 34.33  ?  741 HOH A O   1 
HETATM 3226 O  O   . HOH E 5 .   ? -22.072 -52.909 7.293   1.00 42.32  ?  742 HOH A O   1 
HETATM 3227 O  O   . HOH E 5 .   ? -2.767  -19.938 14.694  1.00 45.31  ?  743 HOH A O   1 
HETATM 3228 O  O   . HOH E 5 .   ? -9.448  -37.146 23.442  1.00 43.82  ?  744 HOH A O   1 
HETATM 3229 O  O   . HOH E 5 .   ? -17.928 -20.830 6.358   1.00 37.83  ?  745 HOH A O   1 
HETATM 3230 O  O   . HOH E 5 .   ? -9.006  -24.784 15.643  1.00 38.23  ?  746 HOH A O   1 
HETATM 3231 O  O   . HOH E 5 .   ? -19.408 -43.108 20.380  1.00 44.49  ?  747 HOH A O   1 
HETATM 3232 O  O   . HOH E 5 .   ? -22.298 -38.003 22.440  1.00 36.93  ?  748 HOH A O   1 
HETATM 3233 O  O   . HOH E 5 .   ? -24.532 -27.519 -22.031 1.00 44.91  ?  749 HOH A O   1 
HETATM 3234 O  O   . HOH E 5 .   ? -7.060  -44.869 19.203  1.00 34.85  ?  750 HOH A O   1 
HETATM 3235 O  O   . HOH E 5 .   ? -7.883  -25.088 -1.018  1.00 24.85  ?  751 HOH A O   1 
HETATM 3236 O  O   . HOH E 5 .   ? -32.779 -26.125 -10.334 1.00 54.30  ?  752 HOH A O   1 
HETATM 3237 O  O   . HOH E 5 .   ? -5.653  -18.070 -0.971  1.00 37.34  ?  753 HOH A O   1 
HETATM 3238 O  O   . HOH E 5 .   ? 1.472   -23.767 -18.787 1.00 38.41  ?  754 HOH A O   1 
HETATM 3239 O  O   . HOH E 5 .   ? -18.892 -25.805 -2.438  1.00 33.64  ?  755 HOH A O   1 
HETATM 3240 O  O   . HOH E 5 .   ? -12.041 -11.772 -21.949 1.00 47.66  ?  756 HOH A O   1 
HETATM 3241 O  O   . HOH E 5 .   ? -1.717  -27.907 -6.261  1.00 29.60  ?  757 HOH A O   1 
HETATM 3242 O  O   . HOH E 5 .   ? -18.554 -34.011 -9.622  1.00 34.60  ?  758 HOH A O   1 
HETATM 3243 O  O   . HOH E 5 .   ? -4.765  -44.906 3.740   1.00 41.25  ?  759 HOH A O   1 
HETATM 3244 O  O   . HOH E 5 .   ? -6.495  -52.842 -2.880  1.00 58.60  ?  760 HOH A O   1 
HETATM 3245 O  O   . HOH E 5 .   ? -28.065 -24.965 -18.229 1.00 40.31  ?  761 HOH A O   1 
HETATM 3246 O  O   . HOH E 5 .   ? -2.732  -33.298 -0.568  1.00 36.97  ?  762 HOH A O   1 
HETATM 3247 O  O   . HOH E 5 .   ? -33.382 -7.619  -14.632 1.00 56.36  ?  763 HOH A O   1 
HETATM 3248 O  O   . HOH E 5 .   ? -27.914 -27.438 14.325  1.00 34.46  ?  764 HOH A O   1 
HETATM 3249 O  O   . HOH E 5 .   ? -24.614 -6.196  -10.319 1.00 41.09  ?  765 HOH A O   1 
HETATM 3250 O  O   . HOH E 5 .   ? -22.118 -45.537 8.952   1.00 33.67  ?  766 HOH A O   1 
HETATM 3251 O  O   . HOH E 5 .   ? -2.388  -40.968 -4.253  1.00 40.63  ?  767 HOH A O   1 
HETATM 3252 O  O   . HOH E 5 .   ? -32.943 -30.025 4.784   1.00 41.99  ?  768 HOH A O   1 
HETATM 3253 O  O   . HOH E 5 .   ? -13.106 -19.052 -5.647  1.00 37.78  ?  769 HOH A O   1 
HETATM 3254 O  O   . HOH E 5 .   ? -15.857 -20.411 -30.714 1.00 59.49  ?  770 HOH A O   1 
HETATM 3255 O  O   . HOH E 5 .   ? -16.689 -25.746 4.394   1.00 33.23  ?  771 HOH A O   1 
HETATM 3256 O  O   . HOH E 5 .   ? -7.347  -24.300 -22.596 1.00 42.47  ?  772 HOH A O   1 
HETATM 3257 O  O   . HOH E 5 .   ? -28.258 -28.169 -5.243  1.00 35.71  ?  773 HOH A O   1 
HETATM 3258 O  O   . HOH E 5 .   ? 1.014   -46.940 17.529  1.00 43.97  ?  774 HOH A O   1 
HETATM 3259 O  O   . HOH E 5 .   ? -30.875 -29.136 6.343   1.00 35.45  ?  775 HOH A O   1 
HETATM 3260 O  O   . HOH E 5 .   ? -3.096  -22.524 3.511   1.00 32.76  ?  776 HOH A O   1 
HETATM 3261 O  O   . HOH E 5 .   ? -10.623 -33.990 -3.598  1.00 35.14  ?  777 HOH A O   1 
HETATM 3262 O  O   . HOH E 5 .   ? -16.470 -14.075 6.111   1.00 51.80  ?  778 HOH A O   1 
HETATM 3263 O  O   . HOH E 5 .   ? -29.472 -13.404 8.814   1.00 42.88  ?  779 HOH A O   1 
HETATM 3264 O  O   . HOH E 5 .   ? -10.962 -13.956 -1.655  1.00 36.01  ?  780 HOH A O   1 
HETATM 3265 O  O   . HOH E 5 .   ? -8.470  -13.726 -4.656  1.00 54.35  ?  781 HOH A O   1 
HETATM 3266 O  O   . HOH E 5 .   ? -12.591 -40.291 20.502  1.00 32.09  ?  782 HOH A O   1 
HETATM 3267 O  O   . HOH E 5 .   ? -35.433 -19.113 -13.047 1.00 55.20  ?  783 HOH A O   1 
HETATM 3268 O  O   . HOH E 5 .   ? -1.473  -47.159 -6.906  1.00 37.88  ?  784 HOH A O   1 
HETATM 3269 O  O   . HOH E 5 .   ? -17.096 -36.753 16.734  1.00 30.48  ?  785 HOH A O   1 
HETATM 3270 O  O   . HOH E 5 .   ? -17.353 -26.955 6.354   1.00 37.93  ?  786 HOH A O   1 
HETATM 3271 O  O   . HOH E 5 .   ? -7.004  -14.674 -7.557  1.00 41.00  ?  787 HOH A O   1 
HETATM 3272 O  O   . HOH E 5 .   ? -9.329  -50.626 16.084  1.00 39.75  ?  788 HOH A O   1 
HETATM 3273 O  O   . HOH E 5 .   ? -0.038  -27.582 8.496   1.00 32.72  ?  789 HOH A O   1 
HETATM 3274 O  O   . HOH E 5 .   ? -31.172 -26.602 -7.561  1.00 44.29  ?  790 HOH A O   1 
HETATM 3275 O  O   . HOH E 5 .   ? -23.812 -32.375 -20.285 1.00 54.90  ?  791 HOH A O   1 
HETATM 3276 O  O   . HOH E 5 .   ? -30.953 -40.373 5.322   1.00 52.09  ?  792 HOH A O   1 
HETATM 3277 O  O   . HOH E 5 .   ? -1.748  -26.138 -9.554  1.00 33.29  ?  793 HOH A O   1 
HETATM 3278 O  O   . HOH E 5 .   ? 0.412   -24.122 7.429   1.00 37.91  ?  794 HOH A O   1 
HETATM 3279 O  O   . HOH E 5 .   ? 0.874   -34.594 2.242   1.00 37.95  ?  795 HOH A O   1 
HETATM 3280 O  O   . HOH E 5 .   ? -32.573 -10.870 -13.749 1.00 47.71  ?  796 HOH A O   1 
HETATM 3281 O  O   . HOH E 5 .   ? -14.402 -51.180 -4.328  1.00 43.56  ?  797 HOH A O   1 
HETATM 3282 O  O   . HOH E 5 .   ? -19.457 -28.715 5.214   1.00 35.12  ?  798 HOH A O   1 
HETATM 3283 O  O   . HOH E 5 .   ? -13.870 -26.109 18.914  1.00 54.47  ?  799 HOH A O   1 
HETATM 3284 O  O   . HOH E 5 .   ? -16.169 -4.948  -11.507 1.00 41.73  ?  800 HOH A O   1 
HETATM 3285 O  O   . HOH E 5 .   ? -20.507 -56.104 -1.909  1.00 56.05  ?  801 HOH A O   1 
HETATM 3286 O  O   . HOH E 5 .   ? -10.786 -21.157 -25.127 1.00 56.82  ?  802 HOH A O   1 
HETATM 3287 O  O   . HOH E 5 .   ? -11.705 -12.590 0.716   1.00 37.45  ?  803 HOH A O   1 
HETATM 3288 O  O   . HOH E 5 .   ? -36.515 -10.040 -7.763  1.00 63.56  ?  804 HOH A O   1 
HETATM 3289 O  O   . HOH E 5 .   ? -29.468 -38.641 -7.513  1.00 38.35  ?  805 HOH A O   1 
HETATM 3290 O  O   . HOH E 5 .   ? -8.792  -55.805 -14.947 1.00 54.38  ?  806 HOH A O   1 
HETATM 3291 O  O   . HOH E 5 .   ? -27.070 -7.087  -10.792 1.00 47.75  ?  807 HOH A O   1 
HETATM 3292 O  O   . HOH E 5 .   ? -16.458 -23.577 5.810   1.00 42.24  ?  808 HOH A O   1 
HETATM 3293 O  O   . HOH E 5 .   ? -18.815 -4.908  -12.747 1.00 43.66  ?  809 HOH A O   1 
HETATM 3294 O  O   . HOH E 5 .   ? -20.202 -19.300 12.788  1.00 60.11  ?  810 HOH A O   1 
HETATM 3295 O  O   . HOH E 5 .   ? -28.655 -12.613 -29.011 1.00 56.31  ?  811 HOH A O   1 
HETATM 3296 O  O   . HOH E 5 .   ? -1.098  -39.921 -13.099 1.00 42.02  ?  812 HOH A O   1 
HETATM 3297 O  O   . HOH E 5 .   ? -32.650 -40.633 15.552  1.00 40.30  ?  813 HOH A O   1 
HETATM 3298 O  O   . HOH E 5 .   ? -32.677 -21.261 5.964   1.00 43.64  ?  814 HOH A O   1 
HETATM 3299 O  O   . HOH E 5 .   ? -9.998  -50.562 3.485   1.00 53.75  ?  815 HOH A O   1 
HETATM 3300 O  O   . HOH E 5 .   ? -23.371 -55.043 1.959   1.00 52.46  ?  816 HOH A O   1 
HETATM 3301 O  O   . HOH E 5 .   ? -27.705 -42.797 5.674   1.00 48.01  ?  817 HOH A O   1 
HETATM 3302 O  O   . HOH E 5 .   ? -0.541  -30.112 7.801   1.00 28.12  ?  818 HOH A O   1 
HETATM 3303 O  O   . HOH E 5 .   ? -5.705  -37.316 21.603  1.00 41.62  ?  819 HOH A O   1 
HETATM 3304 O  O   . HOH E 5 .   ? -15.613 -25.731 -18.242 1.00 43.77  ?  820 HOH A O   1 
HETATM 3305 O  O   . HOH E 5 .   ? -6.638  -20.385 -20.615 1.00 40.83  ?  821 HOH A O   1 
HETATM 3306 O  O   . HOH E 5 .   ? -29.400 -40.556 -0.772  1.00 46.34  ?  822 HOH A O   1 
HETATM 3307 O  O   . HOH E 5 .   ? -10.410 -21.779 -9.260  1.00 30.98  ?  823 HOH A O   1 
HETATM 3308 O  O   . HOH E 5 .   ? -25.837 -42.988 7.640   1.00 38.48  ?  824 HOH A O   1 
HETATM 3309 O  O   . HOH E 5 .   ? -4.222  -20.806 -5.729  1.00 38.69  ?  825 HOH A O   1 
HETATM 3310 O  O   . HOH E 5 .   ? -4.509  -49.016 0.728   1.00 50.50  ?  826 HOH A O   1 
HETATM 3311 O  O   . HOH E 5 .   ? -21.046 -27.761 -3.089  1.00 34.96  ?  827 HOH A O   1 
HETATM 3312 O  O   . HOH E 5 .   ? -11.371 -20.124 -11.324 1.00 30.39  ?  828 HOH A O   1 
HETATM 3313 O  O   . HOH E 5 .   ? -0.794  -44.468 19.693  1.00 49.10  ?  829 HOH A O   1 
HETATM 3314 O  O   . HOH E 5 .   ? -9.678  -8.410  -6.027  1.00 49.11  ?  830 HOH A O   1 
HETATM 3315 O  O   . HOH E 5 .   ? -31.537 -39.481 7.311   1.00 39.42  ?  831 HOH A O   1 
HETATM 3316 O  O   . HOH E 5 .   ? -31.428 -32.636 -3.958  1.00 57.44  ?  832 HOH A O   1 
HETATM 3317 O  O   . HOH E 5 .   ? -13.894 -21.731 -18.335 1.00 34.92  ?  833 HOH A O   1 
HETATM 3318 O  O   . HOH E 5 .   ? -32.880 -29.859 -11.847 1.00 55.77  ?  834 HOH A O   1 
HETATM 3319 O  O   . HOH E 5 .   ? -11.154 -37.649 -14.573 1.00 38.87  ?  835 HOH A O   1 
HETATM 3320 O  O   . HOH E 5 .   ? -18.242 -18.177 7.292   1.00 48.59  ?  836 HOH A O   1 
HETATM 3321 O  O   . HOH E 5 .   ? -13.608 -32.915 21.083  1.00 51.64  ?  837 HOH A O   1 
HETATM 3322 O  O   . HOH E 5 .   ? -27.777 -34.113 -15.227 1.00 53.57  ?  838 HOH A O   1 
HETATM 3323 O  O   . HOH E 5 .   ? -10.578 -28.034 -17.325 1.00 44.85  ?  839 HOH A O   1 
HETATM 3324 O  O   . HOH E 5 .   ? -8.314  -15.609 5.840   1.00 48.95  ?  840 HOH A O   1 
HETATM 3325 O  O   . HOH E 5 .   ? -0.247  -32.391 -9.191  1.00 26.37  ?  841 HOH A O   1 
HETATM 3326 O  O   . HOH E 5 .   ? -26.540 -14.584 13.330  1.00 47.90  ?  842 HOH A O   1 
HETATM 3327 O  O   . HOH E 5 .   ? -34.160 -23.091 -19.971 1.00 50.96  ?  843 HOH A O   1 
HETATM 3328 O  O   . HOH E 5 .   ? -21.195 -4.315  -11.741 1.00 55.11  ?  844 HOH A O   1 
HETATM 3329 O  O   . HOH E 5 .   ? -6.055  -20.389 6.989   1.00 41.75  ?  845 HOH A O   1 
HETATM 3330 O  O   . HOH E 5 .   ? -31.757 -28.250 -2.799  1.00 44.83  ?  846 HOH A O   1 
HETATM 3331 O  O   . HOH E 5 .   ? -14.077 -23.884 -16.882 1.00 40.08  ?  847 HOH A O   1 
HETATM 3332 O  O   . HOH E 5 .   ? -30.691 -30.198 -3.434  1.00 65.88  ?  848 HOH A O   1 
HETATM 3333 O  O   . HOH E 5 .   ? -11.058 -3.559  -6.939  1.00 64.03  ?  849 HOH A O   1 
HETATM 3334 O  O   . HOH E 5 .   ? -6.602  -18.133 -5.304  1.00 44.42  ?  850 HOH A O   1 
HETATM 3335 O  O   . HOH E 5 .   ? -34.787 -21.574 6.918   1.00 44.99  ?  851 HOH A O   1 
HETATM 3336 O  O   . HOH E 5 .   ? -33.587 -9.856  -11.467 1.00 59.59  ?  852 HOH A O   1 
HETATM 3337 O  O   . HOH E 5 .   ? -16.338 -12.712 -25.443 1.00 55.57  ?  853 HOH A O   1 
HETATM 3338 O  O   . HOH E 5 .   ? -7.790  -52.693 7.093   1.00 53.63  ?  854 HOH A O   1 
HETATM 3339 O  O   . HOH E 5 .   ? -15.745 -25.238 8.027   1.00 41.84  ?  855 HOH A O   1 
HETATM 3340 O  O   . HOH E 5 .   ? -7.781  -26.376 17.166  1.00 42.44  ?  856 HOH A O   1 
HETATM 3341 O  O   . HOH E 5 .   ? 1.278   -48.312 11.540  1.00 43.83  ?  857 HOH A O   1 
HETATM 3342 O  O   . HOH E 5 .   ? -10.949 -13.672 2.937   1.00 44.54  ?  858 HOH A O   1 
HETATM 3343 O  O   . HOH E 5 .   ? -1.499  -36.539 11.018  1.00 39.20  ?  859 HOH A O   1 
HETATM 3344 O  O   . HOH E 5 .   ? -13.283 -4.266  -5.688  1.00 51.28  ?  860 HOH A O   1 
HETATM 3345 O  O   . HOH E 5 .   ? -33.027 -15.293 -26.619 1.00 46.59  ?  861 HOH A O   1 
HETATM 3346 O  O   . HOH E 5 .   ? -25.499 -47.932 6.308   1.00 52.54  ?  862 HOH A O   1 
HETATM 3347 O  O   . HOH E 5 .   ? -4.365  -20.958 -9.849  1.00 46.49  ?  863 HOH A O   1 
HETATM 3348 O  O   . HOH E 5 .   ? -21.080 -15.056 -29.666 1.00 65.22  ?  864 HOH A O   1 
HETATM 3349 O  O   . HOH E 5 .   ? -9.598  -44.444 20.654  1.00 51.74  ?  865 HOH A O   1 
HETATM 3350 O  O   . HOH E 5 .   ? -34.054 -25.926 -16.591 1.00 60.43  ?  866 HOH A O   1 
HETATM 3351 O  O   . HOH E 5 .   ? -1.135  -42.929 -23.217 1.00 49.93  ?  867 HOH A O   1 
HETATM 3352 O  O   . HOH E 5 .   ? -6.184  -20.785 -7.308  1.00 40.54  ?  868 HOH A O   1 
HETATM 3353 O  O   . HOH E 5 .   ? -21.502 -14.500 5.686   1.00 45.90  ?  869 HOH A O   1 
HETATM 3354 O  O   . HOH E 5 .   ? -0.496  -36.772 -24.794 1.00 56.38  ?  870 HOH A O   1 
HETATM 3355 O  O   . HOH E 5 .   ? 1.574   -27.822 -24.066 1.00 54.38  ?  871 HOH A O   1 
HETATM 3356 O  O   . HOH E 5 .   ? -15.405 -11.668 -23.096 1.00 52.37  ?  872 HOH A O   1 
HETATM 3357 O  O   . HOH E 5 .   ? 0.883   -41.716 -10.323 1.00 57.19  ?  873 HOH A O   1 
HETATM 3358 O  O   . HOH E 5 .   ? -6.939  -36.905 25.298  1.00 57.31  ?  874 HOH A O   1 
HETATM 3359 O  O   . HOH E 5 .   ? -15.463 -24.770 10.288  1.00 49.01  ?  875 HOH A O   1 
HETATM 3360 O  O   . HOH E 5 .   ? -10.704 -16.125 3.875   1.00 35.48  ?  876 HOH A O   1 
HETATM 3361 O  O   . HOH E 5 .   ? -21.905 -21.101 14.323  1.00 40.53  ?  877 HOH A O   1 
HETATM 3362 O  O   . HOH E 5 .   ? -8.135  -6.123  -14.565 1.00 56.69  ?  878 HOH A O   1 
HETATM 3363 O  O   . HOH E 5 .   ? -7.211  -14.254 -1.666  1.00 49.42  ?  879 HOH A O   1 
HETATM 3364 O  O   . HOH E 5 .   ? -21.761 -53.803 -7.401  1.00 58.02  ?  880 HOH A O   1 
HETATM 3365 O  O   . HOH E 5 .   ? 0.759   -45.894 -6.539  1.00 46.36  ?  881 HOH A O   1 
HETATM 3366 O  O   . HOH E 5 .   ? -20.027 -17.084 13.513  1.00 49.84  ?  882 HOH A O   1 
HETATM 3367 O  O   . HOH E 5 .   ? -30.035 -42.487 6.673   1.00 59.82  ?  883 HOH A O   1 
HETATM 3368 O  O   . HOH E 5 .   ? -41.852 -19.710 12.378  1.00 50.26  ?  884 HOH A O   1 
HETATM 3369 O  O   . HOH E 5 .   ? -32.968 -28.262 -9.578  1.00 64.59  ?  885 HOH A O   1 
HETATM 3370 O  O   . HOH E 5 .   ? -1.415  -18.572 12.796  1.00 54.95  ?  886 HOH A O   1 
HETATM 3371 O  O   . HOH E 5 .   ? -8.542  -22.027 16.129  1.00 48.54  ?  887 HOH A O   1 
HETATM 3372 O  O   . HOH E 5 .   ? -18.476 -13.451 -29.583 1.00 61.80  ?  888 HOH A O   1 
HETATM 3373 O  O   . HOH E 5 .   ? -0.779  -39.215 -1.122  1.00 42.67  ?  889 HOH A O   1 
HETATM 3374 O  O   . HOH E 5 .   ? -8.609  -38.173 -13.547 1.00 43.89  ?  890 HOH A O   1 
HETATM 3375 O  O   . HOH E 5 .   ? -36.157 -18.091 -21.813 1.00 56.37  ?  891 HOH A O   1 
HETATM 3376 O  O   . HOH E 5 .   ? -8.440  -7.243  -16.557 1.00 56.78  ?  892 HOH A O   1 
HETATM 3377 O  O   . HOH E 5 .   ? -33.753 -36.678 5.854   1.00 53.44  ?  893 HOH A O   1 
HETATM 3378 O  O   . HOH E 5 .   ? -39.311 -26.066 11.772  1.00 48.91  ?  894 HOH A O   1 
HETATM 3379 O  O   . HOH E 5 .   ? -10.918 -9.858  0.521   1.00 44.22  ?  895 HOH A O   1 
HETATM 3380 O  O   . HOH E 5 .   ? -34.339 -11.424 -24.816 1.00 47.44  ?  896 HOH A O   1 
HETATM 3381 O  O   . HOH E 5 .   ? -27.678 -43.819 11.074  1.00 48.78  ?  897 HOH A O   1 
HETATM 3382 O  O   . HOH E 5 .   ? -23.659 -53.220 -8.649  1.00 60.19  ?  898 HOH A O   1 
HETATM 3383 O  O   . HOH E 5 .   ? -14.568 -7.099  2.144   1.00 52.44  ?  899 HOH A O   1 
HETATM 3384 O  O   . HOH E 5 .   ? -27.546 -9.492  -0.410  1.00 60.82  ?  900 HOH A O   1 
HETATM 3385 O  O   . HOH E 5 .   ? -5.939  -12.704 -5.903  1.00 56.68  ?  901 HOH A O   1 
HETATM 3386 O  O   . HOH E 5 .   ? -31.429 -38.139 -2.285  1.00 53.14  ?  902 HOH A O   1 
HETATM 3387 O  O   . HOH E 5 .   ? 0.861   -34.934 -8.835  1.00 30.73  ?  903 HOH A O   1 
HETATM 3388 O  O   . HOH E 5 .   ? -1.379  -21.849 -9.958  1.00 45.84  ?  904 HOH A O   1 
HETATM 3389 O  O   . HOH E 5 .   ? -19.342 -15.310 6.782   1.00 43.56  ?  905 HOH A O   1 
HETATM 3390 O  O   . HOH E 5 .   ? -5.608  -16.927 -6.861  1.00 54.43  ?  906 HOH A O   1 
HETATM 3391 O  O   . HOH E 5 .   ? -33.220 -21.925 -24.485 1.00 53.96  ?  907 HOH A O   1 
HETATM 3392 O  O   . HOH E 5 .   ? -34.619 -16.110 -4.825  1.00 52.82  ?  908 HOH A O   1 
HETATM 3393 O  O   . HOH E 5 .   ? -26.198 -46.382 10.723  1.00 53.32  ?  909 HOH A O   1 
HETATM 3394 O  O   . HOH E 5 .   ? -18.880 -16.588 16.145  1.00 61.19  ?  910 HOH A O   1 
HETATM 3395 O  O   . HOH E 5 .   ? -35.804 -18.277 -24.735 1.00 44.65  ?  911 HOH A O   1 
HETATM 3396 O  O   . HOH E 5 .   ? -33.588 -13.870 -3.245  1.00 46.94  ?  912 HOH A O   1 
HETATM 3397 O  O   . HOH E 5 .   ? -7.678  -13.413 0.884   1.00 56.94  ?  913 HOH A O   1 
HETATM 3398 O  O   . HOH E 5 .   ? 1.091   -18.978 -17.654 1.00 46.51  ?  914 HOH A O   1 
HETATM 3399 O  O   . HOH E 5 .   ? -0.155  -22.182 -1.347  1.00 30.59  ?  915 HOH A O   1 
HETATM 3400 O  O   . HOH E 5 .   ? -7.780  -50.364 5.473   1.00 51.94  ?  916 HOH A O   1 
HETATM 3401 O  O   . HOH E 5 .   ? -38.446 -28.265 10.269  1.00 53.05  ?  917 HOH A O   1 
HETATM 3402 O  O   . HOH E 5 .   ? -6.359  -22.036 -22.602 1.00 42.51  ?  918 HOH A O   1 
HETATM 3403 O  O   . HOH E 5 .   ? -10.215 -12.098 -3.525  1.00 44.91  ?  919 HOH A O   1 
HETATM 3404 O  O   . HOH E 5 .   ? -32.557 -38.435 4.337   1.00 60.73  ?  920 HOH A O   1 
HETATM 3405 O  O   . HOH E 5 .   ? -24.826 -45.630 8.172   1.00 43.52  ?  921 HOH A O   1 
HETATM 3406 O  O   . HOH E 5 .   ? -10.821 -39.675 24.423  1.00 59.67  ?  922 HOH A O   1 
HETATM 3407 O  O   . HOH E 5 .   ? 3.319   -21.994 -20.200 1.00 56.00  ?  923 HOH A O   1 
HETATM 3408 O  O   . HOH E 5 .   ? -32.257 -38.696 -6.582  1.00 52.72  ?  924 HOH A O   1 
HETATM 3409 O  O   . HOH E 5 .   ? -2.369  -17.738 -11.481 1.00 62.45  ?  925 HOH A O   1 
HETATM 3410 O  O   . HOH E 5 .   ? -29.909 -19.868 -27.326 1.00 52.31  ?  926 HOH A O   1 
HETATM 3411 O  O   . HOH E 5 .   ? -19.068 -18.381 -28.251 1.00 51.70  ?  927 HOH A O   1 
HETATM 3412 O  O   . HOH E 5 .   ? 0.152   -38.954 -24.466 1.00 46.75  ?  928 HOH A O   1 
HETATM 3413 O  O   . HOH E 5 .   ? -16.294 -54.317 -6.466  1.00 55.30  ?  929 HOH A O   1 
HETATM 3414 O  O   . HOH E 5 .   ? -36.251 -19.133 -2.911  1.00 61.44  ?  930 HOH A O   1 
HETATM 3415 O  O   . HOH E 5 .   ? -20.033 -54.409 8.849   1.00 51.49  ?  931 HOH A O   1 
HETATM 3416 O  O   . HOH E 5 .   ? 0.621   -19.479 11.327  1.00 55.48  ?  932 HOH A O   1 
HETATM 3417 O  O   . HOH E 5 .   ? 2.115   -29.927 -25.323 1.00 70.22  ?  933 HOH A O   1 
HETATM 3418 O  O   . HOH E 5 .   ? -9.202  -10.114 -1.887  1.00 53.86  ?  934 HOH A O   1 
HETATM 3419 O  O   . HOH E 5 .   ? -3.266  -19.555 -1.508  1.00 47.76  ?  935 HOH A O   1 
HETATM 3420 O  O   . HOH E 5 .   ? -6.092  -47.287 3.125   1.00 48.22  ?  936 HOH A O   1 
HETATM 3421 O  O   . HOH E 5 .   ? -13.161 -48.436 18.765  1.00 47.84  ?  937 HOH A O   1 
HETATM 3422 O  O   . HOH E 5 .   ? -2.895  -19.635 -3.866  1.00 47.52  ?  938 HOH A O   1 
HETATM 3423 O  O   . HOH E 5 .   ? -32.330 -18.859 -27.446 1.00 50.92  ?  939 HOH A O   1 
HETATM 3424 O  O   . HOH E 5 .   ? -4.867  -18.281 -9.388  1.00 52.96  ?  940 HOH A O   1 
HETATM 3425 O  O   . HOH E 5 .   ? -12.723 -7.492  4.142   1.00 55.89  ?  941 HOH A O   1 
HETATM 3426 O  O   . HOH E 5 .   ? -0.538  -20.641 3.662   1.00 51.30  ?  942 HOH A O   1 
HETATM 3427 O  O   . HOH E 5 .   ? -33.613 -30.598 -8.284  1.00 59.36  ?  943 HOH A O   1 
# 
