data_8YYV
# 
_entry.id   8YYV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YYV         pdb_00008yyv 10.2210/pdb8yyv/pdb 
WWPDB D_1300046125 ?            ?                   
EMDB  EMD-39680    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-26 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YYV 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'A dimeric STAT1-DNA complex' 
_pdbx_database_related.db_id          EMD-39680 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 5 
_pdbx_contact_author.email              ose.toyoyuki@sci.hokudai.ac.jp 
_pdbx_contact_author.name_first         Toyoyuki 
_pdbx_contact_author.name_last          Ose 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2001-9388 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sugiyama, A.' 1 0000-0001-5211-5297 
'Minami, M.'   2 0009-0000-1534-4920 
'Sugita, Y.'   3 0000-0001-6861-4840 
'Ose, T.'      4 0000-0002-2001-9388 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Sci.Signal. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1937-9145 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            18 
_citation.language                  ? 
_citation.page_first                eads2210 
_citation.page_last                 eads2210 
_citation.title                     
'Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1126/scisignal.ads2210 
_citation.pdbx_database_id_PubMed   40100957 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sugiyama, A.'    1  0000-0001-5211-5297 
primary 'Minami, M.'      2  0009-0000-1534-4920 
primary 'Ugajin, K.'      3  0009-0000-6025-0675 
primary 'Inaba-Inoue, S.' 4  0000-0002-6939-1324 
primary 'Yabuno, N.'      5  ?                   
primary 'Takekawa, Y.'    6  0009-0009-7470-1524 
primary 'Xiaomei, S.'     7  ?                   
primary 'Takei, S.'       8  0009-0001-5873-546X 
primary 'Sasaki, M.'      9  ?                   
primary 'Nomai, T.'       10 0000-0003-3728-9269 
primary 'Jiang, X.'       11 ?                   
primary 'Kita, S.'        12 0000-0003-3969-302X 
primary 'Maenaka, K.'     13 0000-0002-5459-521X 
primary 'Hirose, M.'      14 0000-0001-8991-587X 
primary 'Yao, M.'         15 0000-0003-1687-5904 
primary 'Gooley, P.R.'    16 0000-0002-0323-449X 
primary 'Moseley, G.W.'   17 0000-0003-4516-3906 
primary 'Sugita, Y.'      18 0000-0001-6861-4840 
primary 'Ose, T.'         19 0000-0002-2001-9388 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Signal transducer and activator of transcription 1-alpha/beta'         90766.148 1 ? ? ? 
'signal transducer and activator of transcription' 
2 polymer syn 
;DNA (5'-D(P*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*GP*C)-3')
;
5475.567  1 ? ? ? ?                                                  
3 polymer syn 
;DNA (5'-D(P*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*TP*G)-3')
;
5555.615  1 ? ? ? ?                                                  
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Transcription factor ISGF-3 components p91/p84' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'        no yes 
;MNHKHHHHHHHHHHSSGENLYFQGHMMSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFAT
IRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTV
MLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVV
HKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPI
TKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTV
KGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLP
VVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPD
GLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITF
TWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELD
GPKGTG(PTR)IKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
;
;MNHKHHHHHHHHHHSSGENLYFQGHMMSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFAT
IRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTV
MLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVV
HKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPI
TKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTV
KGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLP
VVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPD
GLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITF
TWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELD
GPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
;
A ? 
2 polydeoxyribonucleotide no no  '(DA)(DC)(DA)(DG)(DT)(DT)(DT)(DC)(DC)(DC)(DG)(DT)(DA)(DA)(DA)(DT)(DG)(DC)' ACAGTTTCCCGTAAATGC C ? 
3 polydeoxyribonucleotide no no  '(DT)(DG)(DC)(DA)(DT)(DT)(DT)(DA)(DC)(DG)(DG)(DG)(DA)(DA)(DA)(DC)(DT)(DG)' TGCATTTACGGGAAACTG B ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASN n 
1 3   HIS n 
1 4   LYS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  HIS n 
1 12  HIS n 
1 13  HIS n 
1 14  HIS n 
1 15  SER n 
1 16  SER n 
1 17  GLY n 
1 18  GLU n 
1 19  ASN n 
1 20  LEU n 
1 21  TYR n 
1 22  PHE n 
1 23  GLN n 
1 24  GLY n 
1 25  HIS n 
1 26  MET n 
1 27  MET n 
1 28  SER n 
1 29  GLN n 
1 30  TRP n 
1 31  TYR n 
1 32  GLU n 
1 33  LEU n 
1 34  GLN n 
1 35  GLN n 
1 36  LEU n 
1 37  ASP n 
1 38  SER n 
1 39  LYS n 
1 40  PHE n 
1 41  LEU n 
1 42  GLU n 
1 43  GLN n 
1 44  VAL n 
1 45  HIS n 
1 46  GLN n 
1 47  LEU n 
1 48  TYR n 
1 49  ASP n 
1 50  ASP n 
1 51  SER n 
1 52  PHE n 
1 53  PRO n 
1 54  MET n 
1 55  GLU n 
1 56  ILE n 
1 57  ARG n 
1 58  GLN n 
1 59  TYR n 
1 60  LEU n 
1 61  ALA n 
1 62  GLN n 
1 63  TRP n 
1 64  LEU n 
1 65  GLU n 
1 66  LYS n 
1 67  GLN n 
1 68  ASP n 
1 69  TRP n 
1 70  GLU n 
1 71  HIS n 
1 72  ALA n 
1 73  ALA n 
1 74  ASN n 
1 75  ASP n 
1 76  VAL n 
1 77  SER n 
1 78  PHE n 
1 79  ALA n 
1 80  THR n 
1 81  ILE n 
1 82  ARG n 
1 83  PHE n 
1 84  HIS n 
1 85  ASP n 
1 86  LEU n 
1 87  LEU n 
1 88  SER n 
1 89  GLN n 
1 90  LEU n 
1 91  ASP n 
1 92  ASP n 
1 93  GLN n 
1 94  TYR n 
1 95  SER n 
1 96  ARG n 
1 97  PHE n 
1 98  SER n 
1 99  LEU n 
1 100 GLU n 
1 101 ASN n 
1 102 ASN n 
1 103 PHE n 
1 104 LEU n 
1 105 LEU n 
1 106 GLN n 
1 107 HIS n 
1 108 ASN n 
1 109 ILE n 
1 110 ARG n 
1 111 LYS n 
1 112 SER n 
1 113 LYS n 
1 114 ARG n 
1 115 ASN n 
1 116 LEU n 
1 117 GLN n 
1 118 ASP n 
1 119 ASN n 
1 120 PHE n 
1 121 GLN n 
1 122 GLU n 
1 123 ASP n 
1 124 PRO n 
1 125 ILE n 
1 126 GLN n 
1 127 MET n 
1 128 SER n 
1 129 MET n 
1 130 ILE n 
1 131 ILE n 
1 132 TYR n 
1 133 SER n 
1 134 CYS n 
1 135 LEU n 
1 136 LYS n 
1 137 GLU n 
1 138 GLU n 
1 139 ARG n 
1 140 LYS n 
1 141 ILE n 
1 142 LEU n 
1 143 GLU n 
1 144 ASN n 
1 145 ALA n 
1 146 GLN n 
1 147 ARG n 
1 148 PHE n 
1 149 ASN n 
1 150 GLN n 
1 151 ALA n 
1 152 GLN n 
1 153 SER n 
1 154 GLY n 
1 155 ASN n 
1 156 ILE n 
1 157 GLN n 
1 158 SER n 
1 159 THR n 
1 160 VAL n 
1 161 MET n 
1 162 LEU n 
1 163 ASP n 
1 164 LYS n 
1 165 GLN n 
1 166 LYS n 
1 167 GLU n 
1 168 LEU n 
1 169 ASP n 
1 170 SER n 
1 171 LYS n 
1 172 VAL n 
1 173 ARG n 
1 174 ASN n 
1 175 VAL n 
1 176 LYS n 
1 177 ASP n 
1 178 LYS n 
1 179 VAL n 
1 180 MET n 
1 181 CYS n 
1 182 ILE n 
1 183 GLU n 
1 184 HIS n 
1 185 GLU n 
1 186 ILE n 
1 187 LYS n 
1 188 SER n 
1 189 LEU n 
1 190 GLU n 
1 191 ASP n 
1 192 LEU n 
1 193 GLN n 
1 194 ASP n 
1 195 GLU n 
1 196 TYR n 
1 197 ASP n 
1 198 PHE n 
1 199 LYS n 
1 200 CYS n 
1 201 LYS n 
1 202 THR n 
1 203 LEU n 
1 204 GLN n 
1 205 ASN n 
1 206 ARG n 
1 207 GLU n 
1 208 HIS n 
1 209 GLU n 
1 210 THR n 
1 211 ASN n 
1 212 GLY n 
1 213 VAL n 
1 214 ALA n 
1 215 LYS n 
1 216 SER n 
1 217 ASP n 
1 218 GLN n 
1 219 LYS n 
1 220 GLN n 
1 221 GLU n 
1 222 GLN n 
1 223 LEU n 
1 224 LEU n 
1 225 LEU n 
1 226 LYS n 
1 227 LYS n 
1 228 MET n 
1 229 TYR n 
1 230 LEU n 
1 231 MET n 
1 232 LEU n 
1 233 ASP n 
1 234 ASN n 
1 235 LYS n 
1 236 ARG n 
1 237 LYS n 
1 238 GLU n 
1 239 VAL n 
1 240 VAL n 
1 241 HIS n 
1 242 LYS n 
1 243 ILE n 
1 244 ILE n 
1 245 GLU n 
1 246 LEU n 
1 247 LEU n 
1 248 ASN n 
1 249 VAL n 
1 250 THR n 
1 251 GLU n 
1 252 LEU n 
1 253 THR n 
1 254 GLN n 
1 255 ASN n 
1 256 ALA n 
1 257 LEU n 
1 258 ILE n 
1 259 ASN n 
1 260 ASP n 
1 261 GLU n 
1 262 LEU n 
1 263 VAL n 
1 264 GLU n 
1 265 TRP n 
1 266 LYS n 
1 267 ARG n 
1 268 ARG n 
1 269 GLN n 
1 270 GLN n 
1 271 SER n 
1 272 ALA n 
1 273 CYS n 
1 274 ILE n 
1 275 GLY n 
1 276 GLY n 
1 277 PRO n 
1 278 PRO n 
1 279 ASN n 
1 280 ALA n 
1 281 CYS n 
1 282 LEU n 
1 283 ASP n 
1 284 GLN n 
1 285 LEU n 
1 286 GLN n 
1 287 ASN n 
1 288 TRP n 
1 289 PHE n 
1 290 THR n 
1 291 ILE n 
1 292 VAL n 
1 293 ALA n 
1 294 GLU n 
1 295 SER n 
1 296 LEU n 
1 297 GLN n 
1 298 GLN n 
1 299 VAL n 
1 300 ARG n 
1 301 GLN n 
1 302 GLN n 
1 303 LEU n 
1 304 LYS n 
1 305 LYS n 
1 306 LEU n 
1 307 GLU n 
1 308 GLU n 
1 309 LEU n 
1 310 GLU n 
1 311 GLN n 
1 312 LYS n 
1 313 TYR n 
1 314 THR n 
1 315 TYR n 
1 316 GLU n 
1 317 HIS n 
1 318 ASP n 
1 319 PRO n 
1 320 ILE n 
1 321 THR n 
1 322 LYS n 
1 323 ASN n 
1 324 LYS n 
1 325 GLN n 
1 326 VAL n 
1 327 LEU n 
1 328 TRP n 
1 329 ASP n 
1 330 ARG n 
1 331 THR n 
1 332 PHE n 
1 333 SER n 
1 334 LEU n 
1 335 PHE n 
1 336 GLN n 
1 337 GLN n 
1 338 LEU n 
1 339 ILE n 
1 340 GLN n 
1 341 SER n 
1 342 SER n 
1 343 PHE n 
1 344 VAL n 
1 345 VAL n 
1 346 GLU n 
1 347 ARG n 
1 348 GLN n 
1 349 PRO n 
1 350 CYS n 
1 351 MET n 
1 352 PRO n 
1 353 THR n 
1 354 HIS n 
1 355 PRO n 
1 356 GLN n 
1 357 ARG n 
1 358 PRO n 
1 359 LEU n 
1 360 VAL n 
1 361 LEU n 
1 362 LYS n 
1 363 THR n 
1 364 GLY n 
1 365 VAL n 
1 366 GLN n 
1 367 PHE n 
1 368 THR n 
1 369 VAL n 
1 370 LYS n 
1 371 LEU n 
1 372 ARG n 
1 373 LEU n 
1 374 LEU n 
1 375 VAL n 
1 376 LYS n 
1 377 LEU n 
1 378 GLN n 
1 379 GLU n 
1 380 LEU n 
1 381 ASN n 
1 382 TYR n 
1 383 ASN n 
1 384 LEU n 
1 385 LYS n 
1 386 VAL n 
1 387 LYS n 
1 388 VAL n 
1 389 LEU n 
1 390 PHE n 
1 391 ASP n 
1 392 LYS n 
1 393 ASP n 
1 394 VAL n 
1 395 ASN n 
1 396 GLU n 
1 397 ARG n 
1 398 ASN n 
1 399 THR n 
1 400 VAL n 
1 401 LYS n 
1 402 GLY n 
1 403 PHE n 
1 404 ARG n 
1 405 LYS n 
1 406 PHE n 
1 407 ASN n 
1 408 ILE n 
1 409 LEU n 
1 410 GLY n 
1 411 THR n 
1 412 HIS n 
1 413 THR n 
1 414 LYS n 
1 415 VAL n 
1 416 MET n 
1 417 ASN n 
1 418 MET n 
1 419 GLU n 
1 420 GLU n 
1 421 SER n 
1 422 THR n 
1 423 ASN n 
1 424 GLY n 
1 425 SER n 
1 426 LEU n 
1 427 ALA n 
1 428 ALA n 
1 429 GLU n 
1 430 PHE n 
1 431 ARG n 
1 432 HIS n 
1 433 LEU n 
1 434 GLN n 
1 435 LEU n 
1 436 LYS n 
1 437 GLU n 
1 438 GLN n 
1 439 LYS n 
1 440 ASN n 
1 441 ALA n 
1 442 GLY n 
1 443 THR n 
1 444 ARG n 
1 445 THR n 
1 446 ASN n 
1 447 GLU n 
1 448 GLY n 
1 449 PRO n 
1 450 LEU n 
1 451 ILE n 
1 452 VAL n 
1 453 THR n 
1 454 GLU n 
1 455 GLU n 
1 456 LEU n 
1 457 HIS n 
1 458 SER n 
1 459 LEU n 
1 460 SER n 
1 461 PHE n 
1 462 GLU n 
1 463 THR n 
1 464 GLN n 
1 465 LEU n 
1 466 CYS n 
1 467 GLN n 
1 468 PRO n 
1 469 GLY n 
1 470 LEU n 
1 471 VAL n 
1 472 ILE n 
1 473 ASP n 
1 474 LEU n 
1 475 GLU n 
1 476 THR n 
1 477 THR n 
1 478 SER n 
1 479 LEU n 
1 480 PRO n 
1 481 VAL n 
1 482 VAL n 
1 483 VAL n 
1 484 ILE n 
1 485 SER n 
1 486 ASN n 
1 487 VAL n 
1 488 SER n 
1 489 GLN n 
1 490 LEU n 
1 491 PRO n 
1 492 SER n 
1 493 GLY n 
1 494 TRP n 
1 495 ALA n 
1 496 SER n 
1 497 ILE n 
1 498 LEU n 
1 499 TRP n 
1 500 TYR n 
1 501 ASN n 
1 502 MET n 
1 503 LEU n 
1 504 VAL n 
1 505 ALA n 
1 506 GLU n 
1 507 PRO n 
1 508 ARG n 
1 509 ASN n 
1 510 LEU n 
1 511 SER n 
1 512 PHE n 
1 513 PHE n 
1 514 LEU n 
1 515 THR n 
1 516 PRO n 
1 517 PRO n 
1 518 CYS n 
1 519 ALA n 
1 520 ARG n 
1 521 TRP n 
1 522 ALA n 
1 523 GLN n 
1 524 LEU n 
1 525 SER n 
1 526 GLU n 
1 527 VAL n 
1 528 LEU n 
1 529 SER n 
1 530 TRP n 
1 531 GLN n 
1 532 PHE n 
1 533 SER n 
1 534 SER n 
1 535 VAL n 
1 536 THR n 
1 537 LYS n 
1 538 ARG n 
1 539 GLY n 
1 540 LEU n 
1 541 ASN n 
1 542 VAL n 
1 543 ASP n 
1 544 GLN n 
1 545 LEU n 
1 546 ASN n 
1 547 MET n 
1 548 LEU n 
1 549 GLY n 
1 550 GLU n 
1 551 LYS n 
1 552 LEU n 
1 553 LEU n 
1 554 GLY n 
1 555 PRO n 
1 556 ASN n 
1 557 ALA n 
1 558 SER n 
1 559 PRO n 
1 560 ASP n 
1 561 GLY n 
1 562 LEU n 
1 563 ILE n 
1 564 PRO n 
1 565 TRP n 
1 566 THR n 
1 567 ARG n 
1 568 PHE n 
1 569 CYS n 
1 570 LYS n 
1 571 GLU n 
1 572 ASN n 
1 573 ILE n 
1 574 ASN n 
1 575 ASP n 
1 576 LYS n 
1 577 ASN n 
1 578 PHE n 
1 579 PRO n 
1 580 PHE n 
1 581 TRP n 
1 582 LEU n 
1 583 TRP n 
1 584 ILE n 
1 585 GLU n 
1 586 SER n 
1 587 ILE n 
1 588 LEU n 
1 589 GLU n 
1 590 LEU n 
1 591 ILE n 
1 592 LYS n 
1 593 LYS n 
1 594 HIS n 
1 595 LEU n 
1 596 LEU n 
1 597 PRO n 
1 598 LEU n 
1 599 TRP n 
1 600 ASN n 
1 601 ASP n 
1 602 GLY n 
1 603 CYS n 
1 604 ILE n 
1 605 MET n 
1 606 GLY n 
1 607 PHE n 
1 608 ILE n 
1 609 SER n 
1 610 LYS n 
1 611 GLU n 
1 612 ARG n 
1 613 GLU n 
1 614 ARG n 
1 615 ALA n 
1 616 LEU n 
1 617 LEU n 
1 618 LYS n 
1 619 ASP n 
1 620 GLN n 
1 621 GLN n 
1 622 PRO n 
1 623 GLY n 
1 624 THR n 
1 625 PHE n 
1 626 LEU n 
1 627 LEU n 
1 628 ARG n 
1 629 PHE n 
1 630 SER n 
1 631 GLU n 
1 632 SER n 
1 633 SER n 
1 634 ARG n 
1 635 GLU n 
1 636 GLY n 
1 637 ALA n 
1 638 ILE n 
1 639 THR n 
1 640 PHE n 
1 641 THR n 
1 642 TRP n 
1 643 VAL n 
1 644 GLU n 
1 645 ARG n 
1 646 SER n 
1 647 GLN n 
1 648 ASN n 
1 649 GLY n 
1 650 GLY n 
1 651 GLU n 
1 652 PRO n 
1 653 ASP n 
1 654 PHE n 
1 655 HIS n 
1 656 ALA n 
1 657 VAL n 
1 658 GLU n 
1 659 PRO n 
1 660 TYR n 
1 661 THR n 
1 662 LYS n 
1 663 LYS n 
1 664 GLU n 
1 665 LEU n 
1 666 SER n 
1 667 ALA n 
1 668 VAL n 
1 669 THR n 
1 670 PHE n 
1 671 PRO n 
1 672 ASP n 
1 673 ILE n 
1 674 ILE n 
1 675 ARG n 
1 676 ASN n 
1 677 TYR n 
1 678 LYS n 
1 679 VAL n 
1 680 MET n 
1 681 ALA n 
1 682 ALA n 
1 683 GLU n 
1 684 ASN n 
1 685 ILE n 
1 686 PRO n 
1 687 GLU n 
1 688 ASN n 
1 689 PRO n 
1 690 LEU n 
1 691 LYS n 
1 692 TYR n 
1 693 LEU n 
1 694 TYR n 
1 695 PRO n 
1 696 ASN n 
1 697 ILE n 
1 698 ASP n 
1 699 LYS n 
1 700 ASP n 
1 701 HIS n 
1 702 ALA n 
1 703 PHE n 
1 704 GLY n 
1 705 LYS n 
1 706 TYR n 
1 707 TYR n 
1 708 SER n 
1 709 ARG n 
1 710 PRO n 
1 711 LYS n 
1 712 GLU n 
1 713 ALA n 
1 714 PRO n 
1 715 GLU n 
1 716 PRO n 
1 717 MET n 
1 718 GLU n 
1 719 LEU n 
1 720 ASP n 
1 721 GLY n 
1 722 PRO n 
1 723 LYS n 
1 724 GLY n 
1 725 THR n 
1 726 GLY n 
1 727 PTR n 
1 728 ILE n 
1 729 LYS n 
1 730 THR n 
1 731 GLU n 
1 732 LEU n 
1 733 ILE n 
1 734 SER n 
1 735 VAL n 
1 736 SER n 
1 737 GLU n 
1 738 VAL n 
1 739 HIS n 
1 740 PRO n 
1 741 SER n 
1 742 ARG n 
1 743 LEU n 
1 744 GLN n 
1 745 THR n 
1 746 THR n 
1 747 ASP n 
1 748 ASN n 
1 749 LEU n 
1 750 LEU n 
1 751 PRO n 
1 752 MET n 
1 753 SER n 
1 754 PRO n 
1 755 GLU n 
1 756 GLU n 
1 757 PHE n 
1 758 ASP n 
1 759 GLU n 
1 760 VAL n 
1 761 SER n 
1 762 ARG n 
1 763 ILE n 
1 764 VAL n 
1 765 GLY n 
1 766 SER n 
1 767 VAL n 
1 768 GLU n 
1 769 PHE n 
1 770 ASP n 
1 771 SER n 
1 772 MET n 
1 773 MET n 
1 774 ASN n 
1 775 THR n 
1 776 VAL n 
2 1   DA  n 
2 2   DC  n 
2 3   DA  n 
2 4   DG  n 
2 5   DT  n 
2 6   DT  n 
2 7   DT  n 
2 8   DC  n 
2 9   DC  n 
2 10  DC  n 
2 11  DG  n 
2 12  DT  n 
2 13  DA  n 
2 14  DA  n 
2 15  DA  n 
2 16  DT  n 
2 17  DG  n 
2 18  DC  n 
3 1   DT  n 
3 2   DG  n 
3 3   DC  n 
3 4   DA  n 
3 5   DT  n 
3 6   DT  n 
3 7   DT  n 
3 8   DA  n 
3 9   DC  n 
3 10  DG  n 
3 11  DG  n 
3 12  DG  n 
3 13  DA  n 
3 14  DA  n 
3 15  DA  n 
3 16  DC  n 
3 17  DT  n 
3 18  DG  n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   776 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 STAT1 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_pdbx_entity_src_syn.entity_id 
_pdbx_entity_src_syn.pdbx_src_id 
_pdbx_entity_src_syn.pdbx_alt_source_flag 
_pdbx_entity_src_syn.pdbx_beg_seq_num 
_pdbx_entity_src_syn.pdbx_end_seq_num 
_pdbx_entity_src_syn.organism_scientific 
_pdbx_entity_src_syn.organism_common_name 
_pdbx_entity_src_syn.ncbi_taxonomy_id 
_pdbx_entity_src_syn.details 
2 1 sample 1 18 'Homo sapiens' ? 9606 ? 
3 1 sample 1 18 'Homo sapiens' ? 9606 ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                              ?                 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                             ?                 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                           ?                 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                      ?                 'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE                             ?                 'C3 H7 N O2 S'    121.158 
DA  'DNA linking'       y "2'-DEOXYADENOSINE-5'-MONOPHOSPHATE" ?                 'C10 H14 N5 O6 P' 331.222 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE"  ?                 'C9 H14 N3 O7 P'  307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE" ?                 'C10 H14 N5 O7 P' 347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE"         ?                 'C10 H15 N2 O8 P' 322.208 
GLN 'L-peptide linking' y GLUTAMINE                            ?                 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                      ?                 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                              ?                 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                            ?                 'C6 H10 N3 O2 1'  156.162 
ILE 'L-peptide linking' y ISOLEUCINE                           ?                 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                              ?                 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                               ?                 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                           ?                 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                        ?                 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                              ?                 'C5 H9 N O2'      115.130 
PTR 'L-peptide linking' n O-PHOSPHOTYROSINE                    PHOSPHONOTYROSINE 'C9 H12 N O6 P'   261.168 
SER 'L-peptide linking' y SERINE                               ?                 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                            ?                 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                           ?                 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                             ?                 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                               ?                 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -25 ?   ?   ?   A . n 
A 1 2   ASN 2   -24 ?   ?   ?   A . n 
A 1 3   HIS 3   -23 ?   ?   ?   A . n 
A 1 4   LYS 4   -22 ?   ?   ?   A . n 
A 1 5   HIS 5   -21 ?   ?   ?   A . n 
A 1 6   HIS 6   -20 ?   ?   ?   A . n 
A 1 7   HIS 7   -19 ?   ?   ?   A . n 
A 1 8   HIS 8   -18 ?   ?   ?   A . n 
A 1 9   HIS 9   -17 ?   ?   ?   A . n 
A 1 10  HIS 10  -16 ?   ?   ?   A . n 
A 1 11  HIS 11  -15 ?   ?   ?   A . n 
A 1 12  HIS 12  -14 ?   ?   ?   A . n 
A 1 13  HIS 13  -13 ?   ?   ?   A . n 
A 1 14  HIS 14  -12 ?   ?   ?   A . n 
A 1 15  SER 15  -11 ?   ?   ?   A . n 
A 1 16  SER 16  -10 ?   ?   ?   A . n 
A 1 17  GLY 17  -9  ?   ?   ?   A . n 
A 1 18  GLU 18  -8  ?   ?   ?   A . n 
A 1 19  ASN 19  -7  ?   ?   ?   A . n 
A 1 20  LEU 20  -6  ?   ?   ?   A . n 
A 1 21  TYR 21  -5  ?   ?   ?   A . n 
A 1 22  PHE 22  -4  ?   ?   ?   A . n 
A 1 23  GLN 23  -3  ?   ?   ?   A . n 
A 1 24  GLY 24  -2  ?   ?   ?   A . n 
A 1 25  HIS 25  -1  ?   ?   ?   A . n 
A 1 26  MET 26  0   ?   ?   ?   A . n 
A 1 27  MET 27  1   ?   ?   ?   A . n 
A 1 28  SER 28  2   ?   ?   ?   A . n 
A 1 29  GLN 29  3   ?   ?   ?   A . n 
A 1 30  TRP 30  4   ?   ?   ?   A . n 
A 1 31  TYR 31  5   ?   ?   ?   A . n 
A 1 32  GLU 32  6   ?   ?   ?   A . n 
A 1 33  LEU 33  7   ?   ?   ?   A . n 
A 1 34  GLN 34  8   ?   ?   ?   A . n 
A 1 35  GLN 35  9   ?   ?   ?   A . n 
A 1 36  LEU 36  10  ?   ?   ?   A . n 
A 1 37  ASP 37  11  ?   ?   ?   A . n 
A 1 38  SER 38  12  ?   ?   ?   A . n 
A 1 39  LYS 39  13  ?   ?   ?   A . n 
A 1 40  PHE 40  14  ?   ?   ?   A . n 
A 1 41  LEU 41  15  ?   ?   ?   A . n 
A 1 42  GLU 42  16  ?   ?   ?   A . n 
A 1 43  GLN 43  17  ?   ?   ?   A . n 
A 1 44  VAL 44  18  ?   ?   ?   A . n 
A 1 45  HIS 45  19  ?   ?   ?   A . n 
A 1 46  GLN 46  20  ?   ?   ?   A . n 
A 1 47  LEU 47  21  ?   ?   ?   A . n 
A 1 48  TYR 48  22  ?   ?   ?   A . n 
A 1 49  ASP 49  23  ?   ?   ?   A . n 
A 1 50  ASP 50  24  ?   ?   ?   A . n 
A 1 51  SER 51  25  ?   ?   ?   A . n 
A 1 52  PHE 52  26  ?   ?   ?   A . n 
A 1 53  PRO 53  27  ?   ?   ?   A . n 
A 1 54  MET 54  28  ?   ?   ?   A . n 
A 1 55  GLU 55  29  ?   ?   ?   A . n 
A 1 56  ILE 56  30  ?   ?   ?   A . n 
A 1 57  ARG 57  31  ?   ?   ?   A . n 
A 1 58  GLN 58  32  ?   ?   ?   A . n 
A 1 59  TYR 59  33  ?   ?   ?   A . n 
A 1 60  LEU 60  34  ?   ?   ?   A . n 
A 1 61  ALA 61  35  ?   ?   ?   A . n 
A 1 62  GLN 62  36  ?   ?   ?   A . n 
A 1 63  TRP 63  37  ?   ?   ?   A . n 
A 1 64  LEU 64  38  ?   ?   ?   A . n 
A 1 65  GLU 65  39  ?   ?   ?   A . n 
A 1 66  LYS 66  40  ?   ?   ?   A . n 
A 1 67  GLN 67  41  ?   ?   ?   A . n 
A 1 68  ASP 68  42  ?   ?   ?   A . n 
A 1 69  TRP 69  43  ?   ?   ?   A . n 
A 1 70  GLU 70  44  ?   ?   ?   A . n 
A 1 71  HIS 71  45  ?   ?   ?   A . n 
A 1 72  ALA 72  46  ?   ?   ?   A . n 
A 1 73  ALA 73  47  ?   ?   ?   A . n 
A 1 74  ASN 74  48  ?   ?   ?   A . n 
A 1 75  ASP 75  49  ?   ?   ?   A . n 
A 1 76  VAL 76  50  ?   ?   ?   A . n 
A 1 77  SER 77  51  ?   ?   ?   A . n 
A 1 78  PHE 78  52  ?   ?   ?   A . n 
A 1 79  ALA 79  53  ?   ?   ?   A . n 
A 1 80  THR 80  54  ?   ?   ?   A . n 
A 1 81  ILE 81  55  ?   ?   ?   A . n 
A 1 82  ARG 82  56  ?   ?   ?   A . n 
A 1 83  PHE 83  57  ?   ?   ?   A . n 
A 1 84  HIS 84  58  ?   ?   ?   A . n 
A 1 85  ASP 85  59  ?   ?   ?   A . n 
A 1 86  LEU 86  60  ?   ?   ?   A . n 
A 1 87  LEU 87  61  ?   ?   ?   A . n 
A 1 88  SER 88  62  ?   ?   ?   A . n 
A 1 89  GLN 89  63  ?   ?   ?   A . n 
A 1 90  LEU 90  64  ?   ?   ?   A . n 
A 1 91  ASP 91  65  ?   ?   ?   A . n 
A 1 92  ASP 92  66  ?   ?   ?   A . n 
A 1 93  GLN 93  67  ?   ?   ?   A . n 
A 1 94  TYR 94  68  ?   ?   ?   A . n 
A 1 95  SER 95  69  ?   ?   ?   A . n 
A 1 96  ARG 96  70  ?   ?   ?   A . n 
A 1 97  PHE 97  71  ?   ?   ?   A . n 
A 1 98  SER 98  72  ?   ?   ?   A . n 
A 1 99  LEU 99  73  ?   ?   ?   A . n 
A 1 100 GLU 100 74  ?   ?   ?   A . n 
A 1 101 ASN 101 75  ?   ?   ?   A . n 
A 1 102 ASN 102 76  ?   ?   ?   A . n 
A 1 103 PHE 103 77  ?   ?   ?   A . n 
A 1 104 LEU 104 78  ?   ?   ?   A . n 
A 1 105 LEU 105 79  ?   ?   ?   A . n 
A 1 106 GLN 106 80  ?   ?   ?   A . n 
A 1 107 HIS 107 81  ?   ?   ?   A . n 
A 1 108 ASN 108 82  ?   ?   ?   A . n 
A 1 109 ILE 109 83  ?   ?   ?   A . n 
A 1 110 ARG 110 84  ?   ?   ?   A . n 
A 1 111 LYS 111 85  ?   ?   ?   A . n 
A 1 112 SER 112 86  ?   ?   ?   A . n 
A 1 113 LYS 113 87  ?   ?   ?   A . n 
A 1 114 ARG 114 88  ?   ?   ?   A . n 
A 1 115 ASN 115 89  ?   ?   ?   A . n 
A 1 116 LEU 116 90  ?   ?   ?   A . n 
A 1 117 GLN 117 91  ?   ?   ?   A . n 
A 1 118 ASP 118 92  ?   ?   ?   A . n 
A 1 119 ASN 119 93  ?   ?   ?   A . n 
A 1 120 PHE 120 94  ?   ?   ?   A . n 
A 1 121 GLN 121 95  ?   ?   ?   A . n 
A 1 122 GLU 122 96  ?   ?   ?   A . n 
A 1 123 ASP 123 97  ?   ?   ?   A . n 
A 1 124 PRO 124 98  ?   ?   ?   A . n 
A 1 125 ILE 125 99  ?   ?   ?   A . n 
A 1 126 GLN 126 100 ?   ?   ?   A . n 
A 1 127 MET 127 101 ?   ?   ?   A . n 
A 1 128 SER 128 102 ?   ?   ?   A . n 
A 1 129 MET 129 103 ?   ?   ?   A . n 
A 1 130 ILE 130 104 ?   ?   ?   A . n 
A 1 131 ILE 131 105 ?   ?   ?   A . n 
A 1 132 TYR 132 106 ?   ?   ?   A . n 
A 1 133 SER 133 107 ?   ?   ?   A . n 
A 1 134 CYS 134 108 ?   ?   ?   A . n 
A 1 135 LEU 135 109 ?   ?   ?   A . n 
A 1 136 LYS 136 110 ?   ?   ?   A . n 
A 1 137 GLU 137 111 ?   ?   ?   A . n 
A 1 138 GLU 138 112 ?   ?   ?   A . n 
A 1 139 ARG 139 113 ?   ?   ?   A . n 
A 1 140 LYS 140 114 ?   ?   ?   A . n 
A 1 141 ILE 141 115 ?   ?   ?   A . n 
A 1 142 LEU 142 116 ?   ?   ?   A . n 
A 1 143 GLU 143 117 ?   ?   ?   A . n 
A 1 144 ASN 144 118 ?   ?   ?   A . n 
A 1 145 ALA 145 119 ?   ?   ?   A . n 
A 1 146 GLN 146 120 ?   ?   ?   A . n 
A 1 147 ARG 147 121 ?   ?   ?   A . n 
A 1 148 PHE 148 122 ?   ?   ?   A . n 
A 1 149 ASN 149 123 ?   ?   ?   A . n 
A 1 150 GLN 150 124 ?   ?   ?   A . n 
A 1 151 ALA 151 125 ?   ?   ?   A . n 
A 1 152 GLN 152 126 ?   ?   ?   A . n 
A 1 153 SER 153 127 ?   ?   ?   A . n 
A 1 154 GLY 154 128 ?   ?   ?   A . n 
A 1 155 ASN 155 129 ?   ?   ?   A . n 
A 1 156 ILE 156 130 ?   ?   ?   A . n 
A 1 157 GLN 157 131 ?   ?   ?   A . n 
A 1 158 SER 158 132 ?   ?   ?   A . n 
A 1 159 THR 159 133 ?   ?   ?   A . n 
A 1 160 VAL 160 134 ?   ?   ?   A . n 
A 1 161 MET 161 135 135 MET MET A . n 
A 1 162 LEU 162 136 136 LEU LEU A . n 
A 1 163 ASP 163 137 137 ASP ASP A . n 
A 1 164 LYS 164 138 138 LYS LYS A . n 
A 1 165 GLN 165 139 139 GLN GLN A . n 
A 1 166 LYS 166 140 140 LYS LYS A . n 
A 1 167 GLU 167 141 141 GLU GLU A . n 
A 1 168 LEU 168 142 142 LEU LEU A . n 
A 1 169 ASP 169 143 143 ASP ASP A . n 
A 1 170 SER 170 144 144 SER SER A . n 
A 1 171 LYS 171 145 145 LYS LYS A . n 
A 1 172 VAL 172 146 146 VAL VAL A . n 
A 1 173 ARG 173 147 147 ARG ARG A . n 
A 1 174 ASN 174 148 148 ASN ASN A . n 
A 1 175 VAL 175 149 149 VAL VAL A . n 
A 1 176 LYS 176 150 150 LYS LYS A . n 
A 1 177 ASP 177 151 151 ASP ASP A . n 
A 1 178 LYS 178 152 152 LYS LYS A . n 
A 1 179 VAL 179 153 153 VAL VAL A . n 
A 1 180 MET 180 154 154 MET MET A . n 
A 1 181 CYS 181 155 155 CYS CYS A . n 
A 1 182 ILE 182 156 156 ILE ILE A . n 
A 1 183 GLU 183 157 157 GLU GLU A . n 
A 1 184 HIS 184 158 158 HIS HIS A . n 
A 1 185 GLU 185 159 159 GLU GLU A . n 
A 1 186 ILE 186 160 160 ILE ILE A . n 
A 1 187 LYS 187 161 161 LYS LYS A . n 
A 1 188 SER 188 162 162 SER SER A . n 
A 1 189 LEU 189 163 163 LEU LEU A . n 
A 1 190 GLU 190 164 164 GLU GLU A . n 
A 1 191 ASP 191 165 165 ASP ASP A . n 
A 1 192 LEU 192 166 166 LEU LEU A . n 
A 1 193 GLN 193 167 167 GLN GLN A . n 
A 1 194 ASP 194 168 168 ASP ASP A . n 
A 1 195 GLU 195 169 169 GLU GLU A . n 
A 1 196 TYR 196 170 170 TYR TYR A . n 
A 1 197 ASP 197 171 171 ASP ASP A . n 
A 1 198 PHE 198 172 172 PHE PHE A . n 
A 1 199 LYS 199 173 173 LYS LYS A . n 
A 1 200 CYS 200 174 174 CYS CYS A . n 
A 1 201 LYS 201 175 175 LYS LYS A . n 
A 1 202 THR 202 176 176 THR THR A . n 
A 1 203 LEU 203 177 177 LEU LEU A . n 
A 1 204 GLN 204 178 178 GLN GLN A . n 
A 1 205 ASN 205 179 179 ASN ASN A . n 
A 1 206 ARG 206 180 180 ARG ARG A . n 
A 1 207 GLU 207 181 181 GLU GLU A . n 
A 1 208 HIS 208 182 182 HIS HIS A . n 
A 1 209 GLU 209 183 183 GLU GLU A . n 
A 1 210 THR 210 184 ?   ?   ?   A . n 
A 1 211 ASN 211 185 ?   ?   ?   A . n 
A 1 212 GLY 212 186 ?   ?   ?   A . n 
A 1 213 VAL 213 187 ?   ?   ?   A . n 
A 1 214 ALA 214 188 ?   ?   ?   A . n 
A 1 215 LYS 215 189 ?   ?   ?   A . n 
A 1 216 SER 216 190 ?   ?   ?   A . n 
A 1 217 ASP 217 191 ?   ?   ?   A . n 
A 1 218 GLN 218 192 ?   ?   ?   A . n 
A 1 219 LYS 219 193 ?   ?   ?   A . n 
A 1 220 GLN 220 194 194 GLN GLN A . n 
A 1 221 GLU 221 195 195 GLU GLU A . n 
A 1 222 GLN 222 196 196 GLN GLN A . n 
A 1 223 LEU 223 197 197 LEU LEU A . n 
A 1 224 LEU 224 198 198 LEU LEU A . n 
A 1 225 LEU 225 199 199 LEU LEU A . n 
A 1 226 LYS 226 200 200 LYS LYS A . n 
A 1 227 LYS 227 201 201 LYS LYS A . n 
A 1 228 MET 228 202 202 MET MET A . n 
A 1 229 TYR 229 203 203 TYR TYR A . n 
A 1 230 LEU 230 204 204 LEU LEU A . n 
A 1 231 MET 231 205 205 MET MET A . n 
A 1 232 LEU 232 206 206 LEU LEU A . n 
A 1 233 ASP 233 207 207 ASP ASP A . n 
A 1 234 ASN 234 208 208 ASN ASN A . n 
A 1 235 LYS 235 209 209 LYS LYS A . n 
A 1 236 ARG 236 210 210 ARG ARG A . n 
A 1 237 LYS 237 211 211 LYS LYS A . n 
A 1 238 GLU 238 212 212 GLU GLU A . n 
A 1 239 VAL 239 213 213 VAL VAL A . n 
A 1 240 VAL 240 214 214 VAL VAL A . n 
A 1 241 HIS 241 215 215 HIS HIS A . n 
A 1 242 LYS 242 216 216 LYS LYS A . n 
A 1 243 ILE 243 217 217 ILE ILE A . n 
A 1 244 ILE 244 218 218 ILE ILE A . n 
A 1 245 GLU 245 219 219 GLU GLU A . n 
A 1 246 LEU 246 220 220 LEU LEU A . n 
A 1 247 LEU 247 221 221 LEU LEU A . n 
A 1 248 ASN 248 222 222 ASN ASN A . n 
A 1 249 VAL 249 223 223 VAL VAL A . n 
A 1 250 THR 250 224 224 THR THR A . n 
A 1 251 GLU 251 225 225 GLU GLU A . n 
A 1 252 LEU 252 226 226 LEU LEU A . n 
A 1 253 THR 253 227 227 THR THR A . n 
A 1 254 GLN 254 228 228 GLN GLN A . n 
A 1 255 ASN 255 229 229 ASN ASN A . n 
A 1 256 ALA 256 230 230 ALA ALA A . n 
A 1 257 LEU 257 231 231 LEU LEU A . n 
A 1 258 ILE 258 232 232 ILE ILE A . n 
A 1 259 ASN 259 233 233 ASN ASN A . n 
A 1 260 ASP 260 234 234 ASP ASP A . n 
A 1 261 GLU 261 235 235 GLU GLU A . n 
A 1 262 LEU 262 236 236 LEU LEU A . n 
A 1 263 VAL 263 237 237 VAL VAL A . n 
A 1 264 GLU 264 238 238 GLU GLU A . n 
A 1 265 TRP 265 239 239 TRP TRP A . n 
A 1 266 LYS 266 240 240 LYS LYS A . n 
A 1 267 ARG 267 241 241 ARG ARG A . n 
A 1 268 ARG 268 242 242 ARG ARG A . n 
A 1 269 GLN 269 243 243 GLN GLN A . n 
A 1 270 GLN 270 244 244 GLN GLN A . n 
A 1 271 SER 271 245 245 SER SER A . n 
A 1 272 ALA 272 246 246 ALA ALA A . n 
A 1 273 CYS 273 247 247 CYS CYS A . n 
A 1 274 ILE 274 248 248 ILE ILE A . n 
A 1 275 GLY 275 249 249 GLY GLY A . n 
A 1 276 GLY 276 250 250 GLY GLY A . n 
A 1 277 PRO 277 251 251 PRO PRO A . n 
A 1 278 PRO 278 252 252 PRO PRO A . n 
A 1 279 ASN 279 253 253 ASN ASN A . n 
A 1 280 ALA 280 254 254 ALA ALA A . n 
A 1 281 CYS 281 255 255 CYS CYS A . n 
A 1 282 LEU 282 256 256 LEU LEU A . n 
A 1 283 ASP 283 257 257 ASP ASP A . n 
A 1 284 GLN 284 258 258 GLN GLN A . n 
A 1 285 LEU 285 259 259 LEU LEU A . n 
A 1 286 GLN 286 260 260 GLN GLN A . n 
A 1 287 ASN 287 261 261 ASN ASN A . n 
A 1 288 TRP 288 262 262 TRP TRP A . n 
A 1 289 PHE 289 263 263 PHE PHE A . n 
A 1 290 THR 290 264 264 THR THR A . n 
A 1 291 ILE 291 265 265 ILE ILE A . n 
A 1 292 VAL 292 266 266 VAL VAL A . n 
A 1 293 ALA 293 267 267 ALA ALA A . n 
A 1 294 GLU 294 268 268 GLU GLU A . n 
A 1 295 SER 295 269 269 SER SER A . n 
A 1 296 LEU 296 270 270 LEU LEU A . n 
A 1 297 GLN 297 271 271 GLN GLN A . n 
A 1 298 GLN 298 272 272 GLN GLN A . n 
A 1 299 VAL 299 273 273 VAL VAL A . n 
A 1 300 ARG 300 274 274 ARG ARG A . n 
A 1 301 GLN 301 275 275 GLN GLN A . n 
A 1 302 GLN 302 276 276 GLN GLN A . n 
A 1 303 LEU 303 277 277 LEU LEU A . n 
A 1 304 LYS 304 278 278 LYS LYS A . n 
A 1 305 LYS 305 279 279 LYS LYS A . n 
A 1 306 LEU 306 280 280 LEU LEU A . n 
A 1 307 GLU 307 281 281 GLU GLU A . n 
A 1 308 GLU 308 282 282 GLU GLU A . n 
A 1 309 LEU 309 283 283 LEU LEU A . n 
A 1 310 GLU 310 284 284 GLU GLU A . n 
A 1 311 GLN 311 285 285 GLN GLN A . n 
A 1 312 LYS 312 286 286 LYS LYS A . n 
A 1 313 TYR 313 287 287 TYR TYR A . n 
A 1 314 THR 314 288 288 THR THR A . n 
A 1 315 TYR 315 289 289 TYR TYR A . n 
A 1 316 GLU 316 290 290 GLU GLU A . n 
A 1 317 HIS 317 291 291 HIS HIS A . n 
A 1 318 ASP 318 292 292 ASP ASP A . n 
A 1 319 PRO 319 293 293 PRO PRO A . n 
A 1 320 ILE 320 294 294 ILE ILE A . n 
A 1 321 THR 321 295 295 THR THR A . n 
A 1 322 LYS 322 296 296 LYS LYS A . n 
A 1 323 ASN 323 297 297 ASN ASN A . n 
A 1 324 LYS 324 298 298 LYS LYS A . n 
A 1 325 GLN 325 299 299 GLN GLN A . n 
A 1 326 VAL 326 300 300 VAL VAL A . n 
A 1 327 LEU 327 301 301 LEU LEU A . n 
A 1 328 TRP 328 302 302 TRP TRP A . n 
A 1 329 ASP 329 303 303 ASP ASP A . n 
A 1 330 ARG 330 304 304 ARG ARG A . n 
A 1 331 THR 331 305 305 THR THR A . n 
A 1 332 PHE 332 306 306 PHE PHE A . n 
A 1 333 SER 333 307 307 SER SER A . n 
A 1 334 LEU 334 308 308 LEU LEU A . n 
A 1 335 PHE 335 309 309 PHE PHE A . n 
A 1 336 GLN 336 310 310 GLN GLN A . n 
A 1 337 GLN 337 311 311 GLN GLN A . n 
A 1 338 LEU 338 312 312 LEU LEU A . n 
A 1 339 ILE 339 313 313 ILE ILE A . n 
A 1 340 GLN 340 314 314 GLN GLN A . n 
A 1 341 SER 341 315 315 SER SER A . n 
A 1 342 SER 342 316 316 SER SER A . n 
A 1 343 PHE 343 317 317 PHE PHE A . n 
A 1 344 VAL 344 318 318 VAL VAL A . n 
A 1 345 VAL 345 319 319 VAL VAL A . n 
A 1 346 GLU 346 320 320 GLU GLU A . n 
A 1 347 ARG 347 321 321 ARG ARG A . n 
A 1 348 GLN 348 322 322 GLN GLN A . n 
A 1 349 PRO 349 323 323 PRO PRO A . n 
A 1 350 CYS 350 324 324 CYS CYS A . n 
A 1 351 MET 351 325 325 MET MET A . n 
A 1 352 PRO 352 326 326 PRO PRO A . n 
A 1 353 THR 353 327 327 THR THR A . n 
A 1 354 HIS 354 328 328 HIS HIS A . n 
A 1 355 PRO 355 329 329 PRO PRO A . n 
A 1 356 GLN 356 330 330 GLN GLN A . n 
A 1 357 ARG 357 331 331 ARG ARG A . n 
A 1 358 PRO 358 332 332 PRO PRO A . n 
A 1 359 LEU 359 333 333 LEU LEU A . n 
A 1 360 VAL 360 334 334 VAL VAL A . n 
A 1 361 LEU 361 335 335 LEU LEU A . n 
A 1 362 LYS 362 336 336 LYS LYS A . n 
A 1 363 THR 363 337 337 THR THR A . n 
A 1 364 GLY 364 338 338 GLY GLY A . n 
A 1 365 VAL 365 339 339 VAL VAL A . n 
A 1 366 GLN 366 340 340 GLN GLN A . n 
A 1 367 PHE 367 341 341 PHE PHE A . n 
A 1 368 THR 368 342 342 THR THR A . n 
A 1 369 VAL 369 343 343 VAL VAL A . n 
A 1 370 LYS 370 344 344 LYS LYS A . n 
A 1 371 LEU 371 345 345 LEU LEU A . n 
A 1 372 ARG 372 346 346 ARG ARG A . n 
A 1 373 LEU 373 347 347 LEU LEU A . n 
A 1 374 LEU 374 348 348 LEU LEU A . n 
A 1 375 VAL 375 349 349 VAL VAL A . n 
A 1 376 LYS 376 350 350 LYS LYS A . n 
A 1 377 LEU 377 351 351 LEU LEU A . n 
A 1 378 GLN 378 352 352 GLN GLN A . n 
A 1 379 GLU 379 353 353 GLU GLU A . n 
A 1 380 LEU 380 354 354 LEU LEU A . n 
A 1 381 ASN 381 355 355 ASN ASN A . n 
A 1 382 TYR 382 356 356 TYR TYR A . n 
A 1 383 ASN 383 357 357 ASN ASN A . n 
A 1 384 LEU 384 358 358 LEU LEU A . n 
A 1 385 LYS 385 359 359 LYS LYS A . n 
A 1 386 VAL 386 360 360 VAL VAL A . n 
A 1 387 LYS 387 361 361 LYS LYS A . n 
A 1 388 VAL 388 362 362 VAL VAL A . n 
A 1 389 LEU 389 363 363 LEU LEU A . n 
A 1 390 PHE 390 364 364 PHE PHE A . n 
A 1 391 ASP 391 365 365 ASP ASP A . n 
A 1 392 LYS 392 366 366 LYS LYS A . n 
A 1 393 ASP 393 367 367 ASP ASP A . n 
A 1 394 VAL 394 368 368 VAL VAL A . n 
A 1 395 ASN 395 369 369 ASN ASN A . n 
A 1 396 GLU 396 370 370 GLU GLU A . n 
A 1 397 ARG 397 371 371 ARG ARG A . n 
A 1 398 ASN 398 372 372 ASN ASN A . n 
A 1 399 THR 399 373 373 THR THR A . n 
A 1 400 VAL 400 374 374 VAL VAL A . n 
A 1 401 LYS 401 375 375 LYS LYS A . n 
A 1 402 GLY 402 376 376 GLY GLY A . n 
A 1 403 PHE 403 377 377 PHE PHE A . n 
A 1 404 ARG 404 378 378 ARG ARG A . n 
A 1 405 LYS 405 379 379 LYS LYS A . n 
A 1 406 PHE 406 380 380 PHE PHE A . n 
A 1 407 ASN 407 381 381 ASN ASN A . n 
A 1 408 ILE 408 382 382 ILE ILE A . n 
A 1 409 LEU 409 383 383 LEU LEU A . n 
A 1 410 GLY 410 384 384 GLY GLY A . n 
A 1 411 THR 411 385 385 THR THR A . n 
A 1 412 HIS 412 386 386 HIS HIS A . n 
A 1 413 THR 413 387 387 THR THR A . n 
A 1 414 LYS 414 388 388 LYS LYS A . n 
A 1 415 VAL 415 389 389 VAL VAL A . n 
A 1 416 MET 416 390 390 MET MET A . n 
A 1 417 ASN 417 391 391 ASN ASN A . n 
A 1 418 MET 418 392 392 MET MET A . n 
A 1 419 GLU 419 393 393 GLU GLU A . n 
A 1 420 GLU 420 394 394 GLU GLU A . n 
A 1 421 SER 421 395 395 SER SER A . n 
A 1 422 THR 422 396 396 THR THR A . n 
A 1 423 ASN 423 397 397 ASN ASN A . n 
A 1 424 GLY 424 398 398 GLY GLY A . n 
A 1 425 SER 425 399 399 SER SER A . n 
A 1 426 LEU 426 400 400 LEU LEU A . n 
A 1 427 ALA 427 401 401 ALA ALA A . n 
A 1 428 ALA 428 402 402 ALA ALA A . n 
A 1 429 GLU 429 403 403 GLU GLU A . n 
A 1 430 PHE 430 404 404 PHE PHE A . n 
A 1 431 ARG 431 405 405 ARG ARG A . n 
A 1 432 HIS 432 406 406 HIS HIS A . n 
A 1 433 LEU 433 407 407 LEU LEU A . n 
A 1 434 GLN 434 408 408 GLN GLN A . n 
A 1 435 LEU 435 409 409 LEU LEU A . n 
A 1 436 LYS 436 410 410 LYS LYS A . n 
A 1 437 GLU 437 411 411 GLU GLU A . n 
A 1 438 GLN 438 412 412 GLN GLN A . n 
A 1 439 LYS 439 413 413 LYS LYS A . n 
A 1 440 ASN 440 414 414 ASN ASN A . n 
A 1 441 ALA 441 415 415 ALA ALA A . n 
A 1 442 GLY 442 416 416 GLY GLY A . n 
A 1 443 THR 443 417 417 THR THR A . n 
A 1 444 ARG 444 418 418 ARG ARG A . n 
A 1 445 THR 445 419 419 THR THR A . n 
A 1 446 ASN 446 420 420 ASN ASN A . n 
A 1 447 GLU 447 421 421 GLU GLU A . n 
A 1 448 GLY 448 422 422 GLY GLY A . n 
A 1 449 PRO 449 423 423 PRO PRO A . n 
A 1 450 LEU 450 424 424 LEU LEU A . n 
A 1 451 ILE 451 425 425 ILE ILE A . n 
A 1 452 VAL 452 426 426 VAL VAL A . n 
A 1 453 THR 453 427 427 THR THR A . n 
A 1 454 GLU 454 428 428 GLU GLU A . n 
A 1 455 GLU 455 429 429 GLU GLU A . n 
A 1 456 LEU 456 430 430 LEU LEU A . n 
A 1 457 HIS 457 431 431 HIS HIS A . n 
A 1 458 SER 458 432 432 SER SER A . n 
A 1 459 LEU 459 433 433 LEU LEU A . n 
A 1 460 SER 460 434 434 SER SER A . n 
A 1 461 PHE 461 435 435 PHE PHE A . n 
A 1 462 GLU 462 436 436 GLU GLU A . n 
A 1 463 THR 463 437 437 THR THR A . n 
A 1 464 GLN 464 438 438 GLN GLN A . n 
A 1 465 LEU 465 439 439 LEU LEU A . n 
A 1 466 CYS 466 440 440 CYS CYS A . n 
A 1 467 GLN 467 441 441 GLN GLN A . n 
A 1 468 PRO 468 442 442 PRO PRO A . n 
A 1 469 GLY 469 443 443 GLY GLY A . n 
A 1 470 LEU 470 444 444 LEU LEU A . n 
A 1 471 VAL 471 445 445 VAL VAL A . n 
A 1 472 ILE 472 446 446 ILE ILE A . n 
A 1 473 ASP 473 447 447 ASP ASP A . n 
A 1 474 LEU 474 448 448 LEU LEU A . n 
A 1 475 GLU 475 449 449 GLU GLU A . n 
A 1 476 THR 476 450 450 THR THR A . n 
A 1 477 THR 477 451 451 THR THR A . n 
A 1 478 SER 478 452 452 SER SER A . n 
A 1 479 LEU 479 453 453 LEU LEU A . n 
A 1 480 PRO 480 454 454 PRO PRO A . n 
A 1 481 VAL 481 455 455 VAL VAL A . n 
A 1 482 VAL 482 456 456 VAL VAL A . n 
A 1 483 VAL 483 457 457 VAL VAL A . n 
A 1 484 ILE 484 458 458 ILE ILE A . n 
A 1 485 SER 485 459 459 SER SER A . n 
A 1 486 ASN 486 460 460 ASN ASN A . n 
A 1 487 VAL 487 461 461 VAL VAL A . n 
A 1 488 SER 488 462 462 SER SER A . n 
A 1 489 GLN 489 463 463 GLN GLN A . n 
A 1 490 LEU 490 464 464 LEU LEU A . n 
A 1 491 PRO 491 465 465 PRO PRO A . n 
A 1 492 SER 492 466 466 SER SER A . n 
A 1 493 GLY 493 467 467 GLY GLY A . n 
A 1 494 TRP 494 468 468 TRP TRP A . n 
A 1 495 ALA 495 469 469 ALA ALA A . n 
A 1 496 SER 496 470 470 SER SER A . n 
A 1 497 ILE 497 471 471 ILE ILE A . n 
A 1 498 LEU 498 472 472 LEU LEU A . n 
A 1 499 TRP 499 473 473 TRP TRP A . n 
A 1 500 TYR 500 474 474 TYR TYR A . n 
A 1 501 ASN 501 475 475 ASN ASN A . n 
A 1 502 MET 502 476 476 MET MET A . n 
A 1 503 LEU 503 477 477 LEU LEU A . n 
A 1 504 VAL 504 478 478 VAL VAL A . n 
A 1 505 ALA 505 479 479 ALA ALA A . n 
A 1 506 GLU 506 480 480 GLU GLU A . n 
A 1 507 PRO 507 481 481 PRO PRO A . n 
A 1 508 ARG 508 482 482 ARG ARG A . n 
A 1 509 ASN 509 483 483 ASN ASN A . n 
A 1 510 LEU 510 484 484 LEU LEU A . n 
A 1 511 SER 511 485 485 SER SER A . n 
A 1 512 PHE 512 486 486 PHE PHE A . n 
A 1 513 PHE 513 487 487 PHE PHE A . n 
A 1 514 LEU 514 488 488 LEU LEU A . n 
A 1 515 THR 515 489 489 THR THR A . n 
A 1 516 PRO 516 490 490 PRO PRO A . n 
A 1 517 PRO 517 491 491 PRO PRO A . n 
A 1 518 CYS 518 492 492 CYS CYS A . n 
A 1 519 ALA 519 493 493 ALA ALA A . n 
A 1 520 ARG 520 494 494 ARG ARG A . n 
A 1 521 TRP 521 495 495 TRP TRP A . n 
A 1 522 ALA 522 496 496 ALA ALA A . n 
A 1 523 GLN 523 497 497 GLN GLN A . n 
A 1 524 LEU 524 498 498 LEU LEU A . n 
A 1 525 SER 525 499 499 SER SER A . n 
A 1 526 GLU 526 500 500 GLU GLU A . n 
A 1 527 VAL 527 501 501 VAL VAL A . n 
A 1 528 LEU 528 502 502 LEU LEU A . n 
A 1 529 SER 529 503 503 SER SER A . n 
A 1 530 TRP 530 504 504 TRP TRP A . n 
A 1 531 GLN 531 505 505 GLN GLN A . n 
A 1 532 PHE 532 506 506 PHE PHE A . n 
A 1 533 SER 533 507 507 SER SER A . n 
A 1 534 SER 534 508 508 SER SER A . n 
A 1 535 VAL 535 509 509 VAL VAL A . n 
A 1 536 THR 536 510 510 THR THR A . n 
A 1 537 LYS 537 511 511 LYS LYS A . n 
A 1 538 ARG 538 512 512 ARG ARG A . n 
A 1 539 GLY 539 513 513 GLY GLY A . n 
A 1 540 LEU 540 514 514 LEU LEU A . n 
A 1 541 ASN 541 515 515 ASN ASN A . n 
A 1 542 VAL 542 516 516 VAL VAL A . n 
A 1 543 ASP 543 517 517 ASP ASP A . n 
A 1 544 GLN 544 518 518 GLN GLN A . n 
A 1 545 LEU 545 519 519 LEU LEU A . n 
A 1 546 ASN 546 520 520 ASN ASN A . n 
A 1 547 MET 547 521 521 MET MET A . n 
A 1 548 LEU 548 522 522 LEU LEU A . n 
A 1 549 GLY 549 523 523 GLY GLY A . n 
A 1 550 GLU 550 524 524 GLU GLU A . n 
A 1 551 LYS 551 525 525 LYS LYS A . n 
A 1 552 LEU 552 526 526 LEU LEU A . n 
A 1 553 LEU 553 527 527 LEU LEU A . n 
A 1 554 GLY 554 528 528 GLY GLY A . n 
A 1 555 PRO 555 529 529 PRO PRO A . n 
A 1 556 ASN 556 530 530 ASN ASN A . n 
A 1 557 ALA 557 531 531 ALA ALA A . n 
A 1 558 SER 558 532 532 SER SER A . n 
A 1 559 PRO 559 533 533 PRO PRO A . n 
A 1 560 ASP 560 534 534 ASP ASP A . n 
A 1 561 GLY 561 535 535 GLY GLY A . n 
A 1 562 LEU 562 536 536 LEU LEU A . n 
A 1 563 ILE 563 537 537 ILE ILE A . n 
A 1 564 PRO 564 538 538 PRO PRO A . n 
A 1 565 TRP 565 539 539 TRP TRP A . n 
A 1 566 THR 566 540 540 THR THR A . n 
A 1 567 ARG 567 541 541 ARG ARG A . n 
A 1 568 PHE 568 542 542 PHE PHE A . n 
A 1 569 CYS 569 543 543 CYS CYS A . n 
A 1 570 LYS 570 544 544 LYS LYS A . n 
A 1 571 GLU 571 545 545 GLU GLU A . n 
A 1 572 ASN 572 546 546 ASN ASN A . n 
A 1 573 ILE 573 547 547 ILE ILE A . n 
A 1 574 ASN 574 548 548 ASN ASN A . n 
A 1 575 ASP 575 549 549 ASP ASP A . n 
A 1 576 LYS 576 550 550 LYS LYS A . n 
A 1 577 ASN 577 551 551 ASN ASN A . n 
A 1 578 PHE 578 552 552 PHE PHE A . n 
A 1 579 PRO 579 553 553 PRO PRO A . n 
A 1 580 PHE 580 554 554 PHE PHE A . n 
A 1 581 TRP 581 555 555 TRP TRP A . n 
A 1 582 LEU 582 556 556 LEU LEU A . n 
A 1 583 TRP 583 557 557 TRP TRP A . n 
A 1 584 ILE 584 558 558 ILE ILE A . n 
A 1 585 GLU 585 559 559 GLU GLU A . n 
A 1 586 SER 586 560 560 SER SER A . n 
A 1 587 ILE 587 561 561 ILE ILE A . n 
A 1 588 LEU 588 562 562 LEU LEU A . n 
A 1 589 GLU 589 563 563 GLU GLU A . n 
A 1 590 LEU 590 564 564 LEU LEU A . n 
A 1 591 ILE 591 565 565 ILE ILE A . n 
A 1 592 LYS 592 566 566 LYS LYS A . n 
A 1 593 LYS 593 567 567 LYS LYS A . n 
A 1 594 HIS 594 568 568 HIS HIS A . n 
A 1 595 LEU 595 569 569 LEU LEU A . n 
A 1 596 LEU 596 570 570 LEU LEU A . n 
A 1 597 PRO 597 571 571 PRO PRO A . n 
A 1 598 LEU 598 572 572 LEU LEU A . n 
A 1 599 TRP 599 573 573 TRP TRP A . n 
A 1 600 ASN 600 574 574 ASN ASN A . n 
A 1 601 ASP 601 575 575 ASP ASP A . n 
A 1 602 GLY 602 576 576 GLY GLY A . n 
A 1 603 CYS 603 577 577 CYS CYS A . n 
A 1 604 ILE 604 578 578 ILE ILE A . n 
A 1 605 MET 605 579 579 MET MET A . n 
A 1 606 GLY 606 580 580 GLY GLY A . n 
A 1 607 PHE 607 581 581 PHE PHE A . n 
A 1 608 ILE 608 582 582 ILE ILE A . n 
A 1 609 SER 609 583 583 SER SER A . n 
A 1 610 LYS 610 584 584 LYS LYS A . n 
A 1 611 GLU 611 585 585 GLU GLU A . n 
A 1 612 ARG 612 586 586 ARG ARG A . n 
A 1 613 GLU 613 587 587 GLU GLU A . n 
A 1 614 ARG 614 588 588 ARG ARG A . n 
A 1 615 ALA 615 589 589 ALA ALA A . n 
A 1 616 LEU 616 590 590 LEU LEU A . n 
A 1 617 LEU 617 591 591 LEU LEU A . n 
A 1 618 LYS 618 592 592 LYS LYS A . n 
A 1 619 ASP 619 593 593 ASP ASP A . n 
A 1 620 GLN 620 594 594 GLN GLN A . n 
A 1 621 GLN 621 595 595 GLN GLN A . n 
A 1 622 PRO 622 596 596 PRO PRO A . n 
A 1 623 GLY 623 597 597 GLY GLY A . n 
A 1 624 THR 624 598 598 THR THR A . n 
A 1 625 PHE 625 599 599 PHE PHE A . n 
A 1 626 LEU 626 600 600 LEU LEU A . n 
A 1 627 LEU 627 601 601 LEU LEU A . n 
A 1 628 ARG 628 602 602 ARG ARG A . n 
A 1 629 PHE 629 603 603 PHE PHE A . n 
A 1 630 SER 630 604 604 SER SER A . n 
A 1 631 GLU 631 605 605 GLU GLU A . n 
A 1 632 SER 632 606 606 SER SER A . n 
A 1 633 SER 633 607 607 SER SER A . n 
A 1 634 ARG 634 608 608 ARG ARG A . n 
A 1 635 GLU 635 609 609 GLU GLU A . n 
A 1 636 GLY 636 610 610 GLY GLY A . n 
A 1 637 ALA 637 611 611 ALA ALA A . n 
A 1 638 ILE 638 612 612 ILE ILE A . n 
A 1 639 THR 639 613 613 THR THR A . n 
A 1 640 PHE 640 614 614 PHE PHE A . n 
A 1 641 THR 641 615 615 THR THR A . n 
A 1 642 TRP 642 616 616 TRP TRP A . n 
A 1 643 VAL 643 617 617 VAL VAL A . n 
A 1 644 GLU 644 618 618 GLU GLU A . n 
A 1 645 ARG 645 619 619 ARG ARG A . n 
A 1 646 SER 646 620 620 SER SER A . n 
A 1 647 GLN 647 621 621 GLN GLN A . n 
A 1 648 ASN 648 622 622 ASN ASN A . n 
A 1 649 GLY 649 623 623 GLY GLY A . n 
A 1 650 GLY 650 624 624 GLY GLY A . n 
A 1 651 GLU 651 625 625 GLU GLU A . n 
A 1 652 PRO 652 626 626 PRO PRO A . n 
A 1 653 ASP 653 627 627 ASP ASP A . n 
A 1 654 PHE 654 628 628 PHE PHE A . n 
A 1 655 HIS 655 629 629 HIS HIS A . n 
A 1 656 ALA 656 630 630 ALA ALA A . n 
A 1 657 VAL 657 631 631 VAL VAL A . n 
A 1 658 GLU 658 632 632 GLU GLU A . n 
A 1 659 PRO 659 633 633 PRO PRO A . n 
A 1 660 TYR 660 634 634 TYR TYR A . n 
A 1 661 THR 661 635 635 THR THR A . n 
A 1 662 LYS 662 636 636 LYS LYS A . n 
A 1 663 LYS 663 637 637 LYS LYS A . n 
A 1 664 GLU 664 638 638 GLU GLU A . n 
A 1 665 LEU 665 639 639 LEU LEU A . n 
A 1 666 SER 666 640 640 SER SER A . n 
A 1 667 ALA 667 641 641 ALA ALA A . n 
A 1 668 VAL 668 642 642 VAL VAL A . n 
A 1 669 THR 669 643 643 THR THR A . n 
A 1 670 PHE 670 644 644 PHE PHE A . n 
A 1 671 PRO 671 645 645 PRO PRO A . n 
A 1 672 ASP 672 646 646 ASP ASP A . n 
A 1 673 ILE 673 647 647 ILE ILE A . n 
A 1 674 ILE 674 648 648 ILE ILE A . n 
A 1 675 ARG 675 649 649 ARG ARG A . n 
A 1 676 ASN 676 650 650 ASN ASN A . n 
A 1 677 TYR 677 651 651 TYR TYR A . n 
A 1 678 LYS 678 652 652 LYS LYS A . n 
A 1 679 VAL 679 653 653 VAL VAL A . n 
A 1 680 MET 680 654 654 MET MET A . n 
A 1 681 ALA 681 655 655 ALA ALA A . n 
A 1 682 ALA 682 656 656 ALA ALA A . n 
A 1 683 GLU 683 657 657 GLU GLU A . n 
A 1 684 ASN 684 658 658 ASN ASN A . n 
A 1 685 ILE 685 659 659 ILE ILE A . n 
A 1 686 PRO 686 660 660 PRO PRO A . n 
A 1 687 GLU 687 661 661 GLU GLU A . n 
A 1 688 ASN 688 662 662 ASN ASN A . n 
A 1 689 PRO 689 663 663 PRO PRO A . n 
A 1 690 LEU 690 664 664 LEU LEU A . n 
A 1 691 LYS 691 665 665 LYS LYS A . n 
A 1 692 TYR 692 666 666 TYR TYR A . n 
A 1 693 LEU 693 667 667 LEU LEU A . n 
A 1 694 TYR 694 668 668 TYR TYR A . n 
A 1 695 PRO 695 669 669 PRO PRO A . n 
A 1 696 ASN 696 670 670 ASN ASN A . n 
A 1 697 ILE 697 671 671 ILE ILE A . n 
A 1 698 ASP 698 672 672 ASP ASP A . n 
A 1 699 LYS 699 673 673 LYS LYS A . n 
A 1 700 ASP 700 674 674 ASP ASP A . n 
A 1 701 HIS 701 675 675 HIS HIS A . n 
A 1 702 ALA 702 676 676 ALA ALA A . n 
A 1 703 PHE 703 677 677 PHE PHE A . n 
A 1 704 GLY 704 678 678 GLY GLY A . n 
A 1 705 LYS 705 679 679 LYS LYS A . n 
A 1 706 TYR 706 680 680 TYR TYR A . n 
A 1 707 TYR 707 681 681 TYR TYR A . n 
A 1 708 SER 708 682 682 SER SER A . n 
A 1 709 ARG 709 683 683 ARG ARG A . n 
A 1 710 PRO 710 684 684 PRO PRO A . n 
A 1 711 LYS 711 685 ?   ?   ?   A . n 
A 1 712 GLU 712 686 ?   ?   ?   A . n 
A 1 713 ALA 713 687 ?   ?   ?   A . n 
A 1 714 PRO 714 688 ?   ?   ?   A . n 
A 1 715 GLU 715 689 ?   ?   ?   A . n 
A 1 716 PRO 716 690 ?   ?   ?   A . n 
A 1 717 MET 717 691 ?   ?   ?   A . n 
A 1 718 GLU 718 692 ?   ?   ?   A . n 
A 1 719 LEU 719 693 ?   ?   ?   A . n 
A 1 720 ASP 720 694 ?   ?   ?   A . n 
A 1 721 GLY 721 695 ?   ?   ?   A . n 
A 1 722 PRO 722 696 ?   ?   ?   A . n 
A 1 723 LYS 723 697 ?   ?   ?   A . n 
A 1 724 GLY 724 698 ?   ?   ?   A . n 
A 1 725 THR 725 699 699 THR THR A . n 
A 1 726 GLY 726 700 700 GLY GLY A . n 
A 1 727 PTR 727 701 701 PTR PTR A . n 
A 1 728 ILE 728 702 702 ILE ILE A . n 
A 1 729 LYS 729 703 703 LYS LYS A . n 
A 1 730 THR 730 704 704 THR THR A . n 
A 1 731 GLU 731 705 705 GLU GLU A . n 
A 1 732 LEU 732 706 706 LEU LEU A . n 
A 1 733 ILE 733 707 707 ILE ILE A . n 
A 1 734 SER 734 708 708 SER SER A . n 
A 1 735 VAL 735 709 709 VAL VAL A . n 
A 1 736 SER 736 710 710 SER SER A . n 
A 1 737 GLU 737 711 711 GLU GLU A . n 
A 1 738 VAL 738 712 ?   ?   ?   A . n 
A 1 739 HIS 739 713 ?   ?   ?   A . n 
A 1 740 PRO 740 714 ?   ?   ?   A . n 
A 1 741 SER 741 715 ?   ?   ?   A . n 
A 1 742 ARG 742 716 ?   ?   ?   A . n 
A 1 743 LEU 743 717 ?   ?   ?   A . n 
A 1 744 GLN 744 718 ?   ?   ?   A . n 
A 1 745 THR 745 719 ?   ?   ?   A . n 
A 1 746 THR 746 720 ?   ?   ?   A . n 
A 1 747 ASP 747 721 ?   ?   ?   A . n 
A 1 748 ASN 748 722 ?   ?   ?   A . n 
A 1 749 LEU 749 723 ?   ?   ?   A . n 
A 1 750 LEU 750 724 ?   ?   ?   A . n 
A 1 751 PRO 751 725 ?   ?   ?   A . n 
A 1 752 MET 752 726 ?   ?   ?   A . n 
A 1 753 SER 753 727 ?   ?   ?   A . n 
A 1 754 PRO 754 728 ?   ?   ?   A . n 
A 1 755 GLU 755 729 ?   ?   ?   A . n 
A 1 756 GLU 756 730 ?   ?   ?   A . n 
A 1 757 PHE 757 731 ?   ?   ?   A . n 
A 1 758 ASP 758 732 ?   ?   ?   A . n 
A 1 759 GLU 759 733 ?   ?   ?   A . n 
A 1 760 VAL 760 734 ?   ?   ?   A . n 
A 1 761 SER 761 735 ?   ?   ?   A . n 
A 1 762 ARG 762 736 ?   ?   ?   A . n 
A 1 763 ILE 763 737 ?   ?   ?   A . n 
A 1 764 VAL 764 738 ?   ?   ?   A . n 
A 1 765 GLY 765 739 ?   ?   ?   A . n 
A 1 766 SER 766 740 ?   ?   ?   A . n 
A 1 767 VAL 767 741 ?   ?   ?   A . n 
A 1 768 GLU 768 742 ?   ?   ?   A . n 
A 1 769 PHE 769 743 ?   ?   ?   A . n 
A 1 770 ASP 770 744 ?   ?   ?   A . n 
A 1 771 SER 771 745 ?   ?   ?   A . n 
A 1 772 MET 772 746 ?   ?   ?   A . n 
A 1 773 MET 773 747 ?   ?   ?   A . n 
A 1 774 ASN 774 748 ?   ?   ?   A . n 
A 1 775 THR 775 749 ?   ?   ?   A . n 
A 1 776 VAL 776 750 ?   ?   ?   A . n 
B 2 1   DA  1   1   1   DA  DA  C . n 
B 2 2   DC  2   2   2   DC  DC  C . n 
B 2 3   DA  3   3   3   DA  DA  C . n 
B 2 4   DG  4   4   4   DG  DG  C . n 
B 2 5   DT  5   5   5   DT  DT  C . n 
B 2 6   DT  6   6   6   DT  DT  C . n 
B 2 7   DT  7   7   7   DT  DT  C . n 
B 2 8   DC  8   8   8   DC  DC  C . n 
B 2 9   DC  9   9   9   DC  DC  C . n 
B 2 10  DC  10  10  10  DC  DC  C . n 
B 2 11  DG  11  11  11  DG  DG  C . n 
B 2 12  DT  12  12  12  DT  DT  C . n 
B 2 13  DA  13  13  13  DA  DA  C . n 
B 2 14  DA  14  14  14  DA  DA  C . n 
B 2 15  DA  15  15  15  DA  DA  C . n 
B 2 16  DT  16  16  16  DT  DT  C . n 
B 2 17  DG  17  17  17  DG  DG  C . n 
B 2 18  DC  18  18  18  DC  DC  C . n 
C 3 1   DT  1   1   1   DT  DT  B . n 
C 3 2   DG  2   2   2   DG  DG  B . n 
C 3 3   DC  3   3   3   DC  DC  B . n 
C 3 4   DA  4   4   4   DA  DA  B . n 
C 3 5   DT  5   5   5   DT  DT  B . n 
C 3 6   DT  6   6   6   DT  DT  B . n 
C 3 7   DT  7   7   7   DT  DT  B . n 
C 3 8   DA  8   8   8   DA  DA  B . n 
C 3 9   DC  9   9   9   DC  DC  B . n 
C 3 10  DG  10  10  10  DG  DG  B . n 
C 3 11  DG  11  11  11  DG  DG  B . n 
C 3 12  DG  12  12  12  DG  DG  B . n 
C 3 13  DA  13  13  13  DA  DA  B . n 
C 3 14  DA  14  14  14  DA  DA  B . n 
C 3 15  DA  15  15  15  DA  DA  B . n 
C 3 16  DC  16  16  16  DC  DC  B . n 
C 3 17  DT  17  17  17  DT  DT  B . n 
C 3 18  DG  18  18  18  DG  DG  B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        PTR 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   PTR 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 195 ? CG  ? A GLU 221 CG  
2  1 Y 1 A GLU 195 ? CD  ? A GLU 221 CD  
3  1 Y 1 A GLU 195 ? OE1 ? A GLU 221 OE1 
4  1 Y 1 A GLU 195 ? OE2 ? A GLU 221 OE2 
5  1 Y 1 A LEU 197 ? CG  ? A LEU 223 CG  
6  1 Y 1 A LEU 197 ? CD1 ? A LEU 223 CD1 
7  1 Y 1 A LEU 197 ? CD2 ? A LEU 223 CD2 
8  1 Y 1 A LEU 198 ? CG  ? A LEU 224 CG  
9  1 Y 1 A LEU 198 ? CD1 ? A LEU 224 CD1 
10 1 Y 1 A LEU 198 ? CD2 ? A LEU 224 CD2 
11 1 Y 1 A LEU 199 ? CG  ? A LEU 225 CG  
12 1 Y 1 A LEU 199 ? CD1 ? A LEU 225 CD1 
13 1 Y 1 A LEU 199 ? CD2 ? A LEU 225 CD2 
14 1 Y 1 A GLU 657 ? CG  ? A GLU 683 CG  
15 1 Y 1 A GLU 657 ? CD  ? A GLU 683 CD  
16 1 Y 1 A GLU 657 ? OE1 ? A GLU 683 OE1 
17 1 Y 1 A GLU 657 ? OE2 ? A GLU 683 OE2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YYV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YYV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YYV 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               113.477 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.943 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  'HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YYV 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.07 
_refine.ls_d_res_low                             3.07 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     211593 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    100.00 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.26634 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.26634 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'PARAMETERS FOR MASK CACLULATION' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD WITH PHASES' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.135 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             7.494 
_refine.overall_SU_ML                            0.121 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'ELECTRON MICROSCOPY' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       . 
_refine_hist.d_res_low                        . 
_refine_hist.number_atoms_solvent             ? 
_refine_hist.number_atoms_total               5249 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        ? 
_refine_hist.pdbx_number_atoms_nucleic_acid   ? 
_refine_hist.pdbx_number_atoms_ligand         ? 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.016  0.012  5475  ? r_bond_refined_d             ? ? 
'ELECTRON MICROSCOPY' ? 0.000  0.016  4819  ? r_bond_other_d               ? ? 
'ELECTRON MICROSCOPY' ? 2.689  1.840  7504  ? r_angle_refined_deg          ? ? 
'ELECTRON MICROSCOPY' ? 0.902  1.758  11161 ? r_angle_other_deg            ? ? 
'ELECTRON MICROSCOPY' ? 9.447  5.226  737   ? r_dihedral_angle_1_deg       ? ? 
'ELECTRON MICROSCOPY' ? 10.283 5.000  26    ? r_dihedral_angle_2_deg       ? ? 
'ELECTRON MICROSCOPY' ? 20.592 10.000 862   ? r_dihedral_angle_3_deg       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'ELECTRON MICROSCOPY' ? 0.158  0.212  870   ? r_chiral_restr               ? ? 
'ELECTRON MICROSCOPY' ? 0.012  0.020  5790  ? r_gen_planes_refined         ? ? 
'ELECTRON MICROSCOPY' ? 0.002  0.020  1172  ? r_gen_planes_other           ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'ELECTRON MICROSCOPY' ? 18.574 10.130 2209  ? r_mcbond_it                  ? ? 
'ELECTRON MICROSCOPY' ? 18.574 10.130 2209  ? r_mcbond_other               ? ? 
'ELECTRON MICROSCOPY' ? 27.665 18.069 2756  ? r_mcangle_it                 ? ? 
'ELECTRON MICROSCOPY' ? 27.660 18.069 2757  ? r_mcangle_other              ? ? 
'ELECTRON MICROSCOPY' ? 21.247 12.155 3266  ? r_scbond_it                  ? ? 
'ELECTRON MICROSCOPY' ? 21.247 12.155 3266  ? r_scbond_other               ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'ELECTRON MICROSCOPY' ? 32.301 21.421 4749  ? r_scangle_other              ? ? 
'ELECTRON MICROSCOPY' ? 51.972 151.28 10351 ? r_long_range_B_refined       ? ? 
'ELECTRON MICROSCOPY' ? 51.971 151.29 10352 ? r_long_range_B_other         ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'ELECTRON MICROSCOPY' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'ELECTRON MICROSCOPY' 
_refine_ls_shell.d_res_high                       3.050 
_refine_ls_shell.d_res_low                        3.129 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             0 
_refine_ls_shell.number_reflns_R_work             15592 
_refine_ls_shell.percent_reflns_obs               100.00 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.892 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.000 
# 
loop_
_struct_ncs_oper.id 
_struct_ncs_oper.code 
_struct_ncs_oper.details 
_struct_ncs_oper.matrix[1][1] 
_struct_ncs_oper.matrix[1][2] 
_struct_ncs_oper.matrix[1][3] 
_struct_ncs_oper.matrix[2][1] 
_struct_ncs_oper.matrix[2][2] 
_struct_ncs_oper.matrix[2][3] 
_struct_ncs_oper.matrix[3][1] 
_struct_ncs_oper.matrix[3][2] 
_struct_ncs_oper.matrix[3][3] 
_struct_ncs_oper.vector[1] 
_struct_ncs_oper.vector[2] 
_struct_ncs_oper.vector[3] 
1 given    ? 1.000000  0.000000  0.000000 0.000000 1.000000  0.000000 0.000000 0.000000 1.000000 0.00000   0.00000   0.00000 
2 generate ? -1.000000 -0.000000 0.000000 0.000000 -1.000000 0.000000 0.000000 0.000000 1.000000 224.40000 224.40000 0.00000 
# 
_struct.entry_id                     8YYV 
_struct.title                        'A dimeric STAT1-DNA complex' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YYV 
_struct_keywords.text            'innate immunity, IMMUNE SYSTEM' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP STAT1_HUMAN P42224 ? 1 
;MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQ
HNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEI
KSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVE
RQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSL
AAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIES
ILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELS
AVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
;
1 
2 PDB 8YYV        8YYV   ? 2 ? 1 
3 PDB 8YYV        8YYV   ? 3 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YYV A 27 ? 776 ? P42224 1 ? 750 ? 1 750 
2 2 8YYV C 1  ? 18  ? 8YYV   1 ? 18  ? 1 18  
3 3 8YYV B 1  ? 18  ? 8YYV   1 ? 18  ? 1 18  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YYV MET A 1  ? UNP P42224 ? ? 'initiating methionine' -25 1  
1 8YYV ASN A 2  ? UNP P42224 ? ? 'expression tag'        -24 2  
1 8YYV HIS A 3  ? UNP P42224 ? ? 'expression tag'        -23 3  
1 8YYV LYS A 4  ? UNP P42224 ? ? 'expression tag'        -22 4  
1 8YYV HIS A 5  ? UNP P42224 ? ? 'expression tag'        -21 5  
1 8YYV HIS A 6  ? UNP P42224 ? ? 'expression tag'        -20 6  
1 8YYV HIS A 7  ? UNP P42224 ? ? 'expression tag'        -19 7  
1 8YYV HIS A 8  ? UNP P42224 ? ? 'expression tag'        -18 8  
1 8YYV HIS A 9  ? UNP P42224 ? ? 'expression tag'        -17 9  
1 8YYV HIS A 10 ? UNP P42224 ? ? 'expression tag'        -16 10 
1 8YYV HIS A 11 ? UNP P42224 ? ? 'expression tag'        -15 11 
1 8YYV HIS A 12 ? UNP P42224 ? ? 'expression tag'        -14 12 
1 8YYV HIS A 13 ? UNP P42224 ? ? 'expression tag'        -13 13 
1 8YYV HIS A 14 ? UNP P42224 ? ? 'expression tag'        -12 14 
1 8YYV SER A 15 ? UNP P42224 ? ? 'expression tag'        -11 15 
1 8YYV SER A 16 ? UNP P42224 ? ? 'expression tag'        -10 16 
1 8YYV GLY A 17 ? UNP P42224 ? ? 'expression tag'        -9  17 
1 8YYV GLU A 18 ? UNP P42224 ? ? 'expression tag'        -8  18 
1 8YYV ASN A 19 ? UNP P42224 ? ? 'expression tag'        -7  19 
1 8YYV LEU A 20 ? UNP P42224 ? ? 'expression tag'        -6  20 
1 8YYV TYR A 21 ? UNP P42224 ? ? 'expression tag'        -5  21 
1 8YYV PHE A 22 ? UNP P42224 ? ? 'expression tag'        -4  22 
1 8YYV GLN A 23 ? UNP P42224 ? ? 'expression tag'        -3  23 
1 8YYV GLY A 24 ? UNP P42224 ? ? 'expression tag'        -2  24 
1 8YYV HIS A 25 ? UNP P42224 ? ? 'expression tag'        -1  25 
1 8YYV MET A 26 ? UNP P42224 ? ? 'expression tag'        0   26 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 'complete point assembly'                ? hexameric 6 
2 'point asymmetric unit'                  ? trimeric  3 
3 'point asymmetric unit, std point frame' ? trimeric  3 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 '(1-2)' A,B,C 
2 1       A,B,C 
3 P       A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
P 'transform to point frame' ?     ?     -0.90423819 -0.42702844 0.00000000 149.36811 0.42702844 -0.90423819 0.00000000 53.54293  
0.00000000 0.00000000 1.00000000 -120.48630 
1 'identity operation'       1_555 x,y,z 1.00000000  0.00000000  0.00000000 0.00000   0.00000000 1.00000000  0.00000000 0.00000   
0.00000000 0.00000000 1.00000000 0.00000    
2 'point symmetry operation' ?     ?     -1.00000000 0.00000000  0.00000000 224.39999 0.00000000 -1.00000000 0.00000000 224.39999 
0.00000000 0.00000000 1.00000000 0.00000    
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 163 ? ASN A 205 ? ASP A 137 ASN A 179 1 ? 43 
HELX_P HELX_P2  AA2 LEU A 225 ? ASP A 260 ? LEU A 199 ASP A 234 1 ? 36 
HELX_P HELX_P3  AA3 ASP A 260 ? ILE A 274 ? ASP A 234 ILE A 248 1 ? 15 
HELX_P HELX_P4  AA4 LEU A 282 ? GLN A 311 ? LEU A 256 GLN A 285 1 ? 30 
HELX_P HELX_P5  AA5 ASP A 318 ? ASN A 323 ? ASP A 292 ASN A 297 1 ? 6  
HELX_P HELX_P6  AA6 ASN A 323 ? PHE A 343 ? ASN A 297 PHE A 317 1 ? 21 
HELX_P HELX_P7  AA7 VAL A 394 ? ASN A 398 ? VAL A 368 ASN A 372 5 ? 5  
HELX_P HELX_P8  AA8 GLN A 489 ? VAL A 504 ? GLN A 463 VAL A 478 1 ? 16 
HELX_P HELX_P9  AA9 TRP A 521 ? THR A 536 ? TRP A 495 THR A 510 1 ? 16 
HELX_P HELX_P10 AB1 ASN A 541 ? GLY A 554 ? ASN A 515 GLY A 528 1 ? 14 
HELX_P HELX_P11 AB2 PRO A 564 ? LYS A 570 ? PRO A 538 LYS A 544 1 ? 7  
HELX_P HELX_P12 AB3 PRO A 579 ? LEU A 595 ? PRO A 553 LEU A 569 1 ? 17 
HELX_P HELX_P13 AB4 LEU A 595 ? ASP A 601 ? LEU A 569 ASP A 575 1 ? 7  
HELX_P HELX_P14 AB5 GLU A 613 ? LEU A 617 ? GLU A 587 LEU A 591 5 ? 5  
HELX_P HELX_P15 AB6 THR A 661 ? SER A 666 ? THR A 635 SER A 640 1 ? 6  
HELX_P HELX_P16 AB7 THR A 669 ? TYR A 677 ? THR A 643 TYR A 651 1 ? 9  
HELX_P HELX_P17 AB8 ASP A 698 ? PHE A 703 ? ASP A 672 PHE A 677 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale both ? A GLY 726 C  ? ? ? 1_555 A PTR 727 N  ? ? A GLY 700 A PTR 701 1_555 ? ? ? ? ? ? ?            1.333 ? ? 
covale2  covale both ? A PTR 727 C  ? ? ? 1_555 A ILE 728 N  ? ? A PTR 701 A ILE 702 1_555 ? ? ? ? ? ? ?            1.341 ? ? 
hydrog1  hydrog ?    ? B DC  2   N3 ? ? ? 1_555 C DG  18  N1 ? ? C DC  2   B DG  18  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog2  hydrog ?    ? B DC  2   N4 ? ? ? 1_555 C DG  18  O6 ? ? C DC  2   B DG  18  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog3  hydrog ?    ? B DC  2   O2 ? ? ? 1_555 C DG  18  N2 ? ? C DC  2   B DG  18  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog4  hydrog ?    ? B DA  3   N1 ? ? ? 1_555 C DT  17  N3 ? ? C DA  3   B DT  17  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog5  hydrog ?    ? B DA  3   N6 ? ? ? 1_555 C DT  17  O4 ? ? C DA  3   B DT  17  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog6  hydrog ?    ? B DG  4   N1 ? ? ? 1_555 C DC  16  N3 ? ? C DG  4   B DC  16  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog7  hydrog ?    ? B DG  4   N2 ? ? ? 1_555 C DC  16  O2 ? ? C DG  4   B DC  16  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog8  hydrog ?    ? B DG  4   O6 ? ? ? 1_555 C DC  16  N4 ? ? C DG  4   B DC  16  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog9  hydrog ?    ? B DT  5   N3 ? ? ? 1_555 C DA  15  N1 ? ? C DT  5   B DA  15  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog10 hydrog ?    ? B DT  5   O4 ? ? ? 1_555 C DA  15  N6 ? ? C DT  5   B DA  15  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog11 hydrog ?    ? B DT  6   N3 ? ? ? 1_555 C DA  14  N1 ? ? C DT  6   B DA  14  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog12 hydrog ?    ? B DT  6   O4 ? ? ? 1_555 C DA  14  N6 ? ? C DT  6   B DA  14  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog13 hydrog ?    ? B DT  7   N3 ? ? ? 1_555 C DA  13  N1 ? ? C DT  7   B DA  13  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog14 hydrog ?    ? B DT  7   O4 ? ? ? 1_555 C DA  13  N6 ? ? C DT  7   B DA  13  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog15 hydrog ?    ? B DC  8   N3 ? ? ? 1_555 C DG  12  N1 ? ? C DC  8   B DG  12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog16 hydrog ?    ? B DC  8   N4 ? ? ? 1_555 C DG  12  O6 ? ? C DC  8   B DG  12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog17 hydrog ?    ? B DC  8   O2 ? ? ? 1_555 C DG  12  N2 ? ? C DC  8   B DG  12  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog18 hydrog ?    ? B DC  9   N3 ? ? ? 1_555 C DG  11  N1 ? ? C DC  9   B DG  11  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog19 hydrog ?    ? B DC  9   N4 ? ? ? 1_555 C DG  11  O6 ? ? C DC  9   B DG  11  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog20 hydrog ?    ? B DC  9   O2 ? ? ? 1_555 C DG  11  N2 ? ? C DC  9   B DG  11  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog21 hydrog ?    ? B DC  10  N3 ? ? ? 1_555 C DG  10  N1 ? ? C DC  10  B DG  10  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog22 hydrog ?    ? B DC  10  N4 ? ? ? 1_555 C DG  10  O6 ? ? C DC  10  B DG  10  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog23 hydrog ?    ? B DC  10  O2 ? ? ? 1_555 C DG  10  N2 ? ? C DC  10  B DG  10  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog24 hydrog ?    ? B DG  11  N1 ? ? ? 1_555 C DC  9   N3 ? ? C DG  11  B DC  9   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog25 hydrog ?    ? B DG  11  N2 ? ? ? 1_555 C DC  9   O2 ? ? C DG  11  B DC  9   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog26 hydrog ?    ? B DG  11  O6 ? ? ? 1_555 C DC  9   N4 ? ? C DG  11  B DC  9   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog27 hydrog ?    ? B DT  12  N3 ? ? ? 1_555 C DA  8   N1 ? ? C DT  12  B DA  8   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog28 hydrog ?    ? B DT  12  O4 ? ? ? 1_555 C DA  8   N6 ? ? C DT  12  B DA  8   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog29 hydrog ?    ? B DA  13  N1 ? ? ? 1_555 C DT  7   N3 ? ? C DA  13  B DT  7   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog30 hydrog ?    ? B DA  13  N6 ? ? ? 1_555 C DT  7   O4 ? ? C DA  13  B DT  7   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog31 hydrog ?    ? B DA  14  N1 ? ? ? 1_555 C DT  6   N3 ? ? C DA  14  B DT  6   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog32 hydrog ?    ? B DA  14  N6 ? ? ? 1_555 C DT  6   O4 ? ? C DA  14  B DT  6   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog33 hydrog ?    ? B DA  15  N1 ? ? ? 1_555 C DT  5   N3 ? ? C DA  15  B DT  5   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog34 hydrog ?    ? B DA  15  N6 ? ? ? 1_555 C DT  5   O4 ? ? C DA  15  B DT  5   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog35 hydrog ?    ? B DT  16  N3 ? ? ? 1_555 C DA  4   N1 ? ? C DT  16  B DA  4   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog36 hydrog ?    ? B DT  16  O4 ? ? ? 1_555 C DA  4   N6 ? ? C DT  16  B DA  4   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog37 hydrog ?    ? B DG  17  N1 ? ? ? 1_555 C DC  3   N3 ? ? C DG  17  B DC  3   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog38 hydrog ?    ? B DG  17  N2 ? ? ? 1_555 C DC  3   O2 ? ? C DG  17  B DC  3   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog39 hydrog ?    ? B DG  17  O6 ? ? ? 1_555 C DC  3   N4 ? ? C DG  17  B DC  3   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog40 hydrog ?    ? B DC  18  N3 ? ? ? 1_555 C DG  2   N1 ? ? C DC  18  B DG  2   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog41 hydrog ?    ? B DC  18  N4 ? ? ? 1_555 C DG  2   O6 ? ? C DC  18  B DG  2   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog42 hydrog ?    ? B DC  18  O2 ? ? ? 1_555 C DG  2   N2 ? ? C DC  18  B DG  2   1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
hydrog ? ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      PTR 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       727 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     . 
_pdbx_modification_feature.modified_residue_label_asym_id     . 
_pdbx_modification_feature.modified_residue_label_seq_id      . 
_pdbx_modification_feature.modified_residue_label_alt_id      . 
_pdbx_modification_feature.auth_comp_id                       PTR 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        701 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      . 
_pdbx_modification_feature.modified_residue_auth_asym_id      . 
_pdbx_modification_feature.modified_residue_auth_seq_id       . 
_pdbx_modification_feature.modified_residue_PDB_ins_code      . 
_pdbx_modification_feature.modified_residue_symmetry          . 
_pdbx_modification_feature.comp_id_linking_atom               . 
_pdbx_modification_feature.modified_residue_id_linking_atom   . 
_pdbx_modification_feature.modified_residue_id                TYR 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        PTR 
_pdbx_modification_feature.type                               Phosphorylation 
_pdbx_modification_feature.category                           'Named protein modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 347 ? CYS A 350 ? ARG A 321 CYS A 324 
AA1 2 THR A 368 ? LEU A 373 ? THR A 342 LEU A 347 
AA1 3 LEU A 426 ? PHE A 430 ? LEU A 400 PHE A 404 
AA2 1 VAL A 360 ? LYS A 362 ? VAL A 334 LYS A 336 
AA2 2 VAL A 482 ? ILE A 484 ? VAL A 456 ILE A 458 
AA3 1 LYS A 414 ? VAL A 415 ? LYS A 388 VAL A 389 
AA3 2 LYS A 385 ? PHE A 390 ? LYS A 359 PHE A 364 
AA3 3 LEU A 459 ? CYS A 466 ? LEU A 433 CYS A 440 
AA3 4 VAL A 471 ? THR A 477 ? VAL A 445 THR A 451 
AA4 1 PHE A 406 ? ILE A 408 ? PHE A 380 ILE A 382 
AA4 2 LEU A 435 ? GLU A 437 ? LEU A 409 GLU A 411 
AA5 1 ALA A 519 ? ARG A 520 ? ALA A 493 ARG A 494 
AA5 2 LEU A 562 ? ILE A 563 ? LEU A 536 ILE A 537 
AA6 1 PHE A 625 ? LEU A 626 ? PHE A 599 LEU A 600 
AA6 2 THR A 641 ? TRP A 642 ? THR A 615 TRP A 616 
AA6 3 HIS A 655 ? ALA A 656 ? HIS A 629 ALA A 630 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ARG A 347 ? N ARG A 321 O LYS A 370 ? O LYS A 344 
AA1 2 3 N LEU A 371 ? N LEU A 345 O ALA A 428 ? O ALA A 402 
AA2 1 2 N LEU A 361 ? N LEU A 335 O ILE A 484 ? O ILE A 458 
AA3 1 2 O LYS A 414 ? O LYS A 388 N VAL A 386 ? N VAL A 360 
AA3 2 3 N LEU A 389 ? N LEU A 363 O SER A 460 ? O SER A 434 
AA3 3 4 N LEU A 465 ? N LEU A 439 O ILE A 472 ? O ILE A 446 
AA4 1 2 N ASN A 407 ? N ASN A 381 O LYS A 436 ? O LYS A 410 
AA5 1 2 N ALA A 519 ? N ALA A 493 O ILE A 563 ? O ILE A 537 
AA6 1 2 N LEU A 626 ? N LEU A 600 O THR A 641 ? O THR A 615 
AA6 2 3 N TRP A 642 ? N TRP A 616 O HIS A 655 ? O HIS A 629 
# 
_pdbx_entry_details.entry_id                   8YYV 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A GLU 164 ? ? OD1 A ASP 168 ? ? 1.91 
2 1 O   A LEU 664 ? ? NZ  A LYS 673 ? ? 2.04 
3 1 OE2 A GLU 370 ? ? OG  A SER 485 ? ? 2.06 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1  1 CB    A GLN 244 ? ? CA    A GLN 244 ? ? C   A GLN 244 ? ? 95.10  110.40 -15.30 2.00 N 
2  1 N     A GLN 271 ? ? CA    A GLN 271 ? ? CB  A GLN 271 ? ? 122.30 110.60 11.70  1.80 N 
3  1 CA    A ARG 304 ? ? CB    A ARG 304 ? ? CG  A ARG 304 ? ? 98.21  113.40 -15.19 2.20 N 
4  1 CB    A ARG 321 ? ? CA    A ARG 321 ? ? C   A ARG 321 ? ? 97.19  110.40 -13.21 2.00 N 
5  1 N     A LEU 335 ? ? CA    A LEU 335 ? ? CB  A LEU 335 ? ? 97.08  110.40 -13.32 2.00 N 
6  1 CB    A ARG 346 ? ? CA    A ARG 346 ? ? C   A ARG 346 ? ? 94.42  110.40 -15.98 2.00 N 
7  1 CB    A LEU 347 ? ? CG    A LEU 347 ? ? CD1 A LEU 347 ? ? 97.38  111.00 -13.62 1.70 N 
8  1 OG1   A THR 427 ? ? CB    A THR 427 ? ? CG2 A THR 427 ? ? 84.99  110.00 -25.01 2.30 N 
9  1 CB    A GLU 428 ? ? CA    A GLU 428 ? ? C   A GLU 428 ? ? 92.81  110.40 -17.59 2.00 N 
10 1 CB    A LEU 453 ? ? CG    A LEU 453 ? ? CD2 A LEU 453 ? ? 99.45  111.00 -11.55 1.70 N 
11 1 CG    A MET 521 ? ? SD    A MET 521 ? ? CE  A MET 521 ? ? 87.43  100.20 -12.77 1.60 N 
12 1 N     A LEU 590 ? ? CA    A LEU 590 ? ? CB  A LEU 590 ? ? 95.18  110.40 -15.22 2.00 N 
13 1 CB    A LYS 592 ? ? CA    A LYS 592 ? ? C   A LYS 592 ? ? 124.22 110.40 13.82  2.00 N 
14 1 N     A PRO 596 ? ? CA    A PRO 596 ? ? CB  A PRO 596 ? ? 95.68  103.30 -7.62  1.20 N 
15 1 N     A PHE 599 ? ? CA    A PHE 599 ? ? CB  A PHE 599 ? ? 93.34  110.60 -17.26 1.80 N 
16 1 CB    A LEU 600 ? ? CG    A LEU 600 ? ? CD1 A LEU 600 ? ? 121.89 111.00 10.89  1.70 N 
17 1 CB    A LEU 600 ? ? CG    A LEU 600 ? ? CD2 A LEU 600 ? ? 99.84  111.00 -11.16 1.70 N 
18 1 CB    A VAL 617 ? ? CA    A VAL 617 ? ? C   A VAL 617 ? ? 99.94  111.40 -11.46 1.90 N 
19 1 CA    A THR 635 ? ? CB    A THR 635 ? ? OG1 A THR 635 ? ? 93.11  109.00 -15.89 2.10 N 
20 1 NE    A ARG 649 ? ? CZ    A ARG 649 ? ? NH2 A ARG 649 ? ? 117.00 120.30 -3.30  0.50 N 
21 1 N     A TYR 668 ? ? CA    A TYR 668 ? ? CB  A TYR 668 ? ? 127.56 110.60 16.96  1.80 N 
22 1 "O5'" C DT  7   ? ? P     C DT  7   ? ? OP2 C DT  7   ? ? 100.22 105.70 -5.48  0.90 N 
23 1 "O4'" B DT  6   ? ? "C1'" B DT  6   ? ? N1  B DT  6   ? ? 103.64 108.00 -4.36  0.70 N 
24 1 "O4'" B DA  8   ? ? "C1'" B DA  8   ? ? N9  B DA  8   ? ? 110.28 108.30 1.98   0.30 N 
25 1 "O4'" B DA  13  ? ? "C1'" B DA  13  ? ? N9  B DA  13  ? ? 110.18 108.30 1.88   0.30 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU A 136 ? ? -91.19  42.77   
2  1 GLU A 141 ? ? -39.84  -72.81  
3  1 HIS A 158 ? ? -61.61  -73.46  
4  1 GLU A 159 ? ? -31.17  -37.60  
5  1 ARG A 180 ? ? -164.74 94.66   
6  1 GLU A 181 ? ? 167.26  35.50   
7  1 GLU A 195 ? ? -99.68  -86.60  
8  1 GLN A 196 ? ? 85.32   176.45  
9  1 LEU A 197 ? ? 177.45  106.85  
10 1 MET A 202 ? ? 152.17  -56.36  
11 1 ASP A 207 ? ? -76.88  -79.76  
12 1 ASN A 208 ? ? -27.65  -58.30  
13 1 ASP A 234 ? ? -98.76  -62.16  
14 1 GLN A 244 ? ? -37.56  -32.95  
15 1 ILE A 248 ? ? -87.06  30.67   
16 1 ASN A 261 ? ? -60.53  -70.11  
17 1 LYS A 286 ? ? -107.33 -79.61  
18 1 TYR A 289 ? ? -178.15 -168.29 
19 1 PRO A 293 ? ? -33.41  -28.50  
20 1 HIS A 328 ? ? -150.71 68.19   
21 1 PRO A 332 ? ? -103.79 67.00   
22 1 LEU A 333 ? ? -168.90 26.04   
23 1 ASP A 367 ? ? 88.69   22.14   
24 1 HIS A 386 ? ? -76.48  -95.63  
25 1 THR A 387 ? ? -35.71  129.94  
26 1 GLU A 393 ? ? -71.93  -153.65 
27 1 GLU A 394 ? ? 56.06   -89.43  
28 1 SER A 399 ? ? 61.87   113.06  
29 1 HIS A 406 ? ? 53.51   77.01   
30 1 ASN A 414 ? ? -149.03 33.43   
31 1 ALA A 415 ? ? 43.14   -108.87 
32 1 PRO A 423 ? ? -118.38 -141.30 
33 1 VAL A 426 ? ? -58.45  178.46  
34 1 THR A 427 ? ? -68.09  68.43   
35 1 THR A 437 ? ? -177.33 -169.57 
36 1 PRO A 442 ? ? -51.77  102.88  
37 1 VAL A 445 ? ? -162.53 78.78   
38 1 GLU A 449 ? ? 174.89  138.32  
39 1 THR A 450 ? ? -163.89 -169.92 
40 1 PRO A 465 ? ? -36.91  -70.23  
41 1 ASN A 475 ? ? -65.35  17.03   
42 1 GLU A 480 ? ? 169.70  -41.19  
43 1 PRO A 481 ? ? -27.02  87.77   
44 1 ARG A 482 ? ? -45.36  76.74   
45 1 LEU A 484 ? ? -54.01  -9.17   
46 1 SER A 485 ? ? -102.63 41.62   
47 1 THR A 510 ? ? -108.41 -140.38 
48 1 ARG A 512 ? ? -173.31 124.19  
49 1 ASN A 515 ? ? -69.83  -176.04 
50 1 ASN A 530 ? ? -103.01 75.94   
51 1 CYS A 543 ? ? -145.32 -32.10  
52 1 GLU A 545 ? ? 157.08  119.03  
53 1 ASN A 548 ? ? -0.85   -66.55  
54 1 HIS A 568 ? ? -154.53 4.29    
55 1 LEU A 569 ? ? -144.59 15.15   
56 1 GLU A 585 ? ? -158.58 -29.96  
57 1 ALA A 589 ? ? -68.82  23.90   
58 1 LEU A 591 ? ? -114.49 61.21   
59 1 ASP A 593 ? ? -80.34  -81.71  
60 1 GLN A 594 ? ? -145.48 -140.65 
61 1 PRO A 596 ? ? -41.93  76.74   
62 1 GLU A 618 ? ? -109.12 -143.29 
63 1 GLN A 621 ? ? 92.88   -19.29  
64 1 PHE A 628 ? ? 55.21   -178.11 
65 1 GLU A 632 ? ? -39.02  127.93  
66 1 THR A 635 ? ? -100.60 -160.38 
67 1 LYS A 652 ? ? -128.16 -59.26  
68 1 VAL A 653 ? ? 68.12   120.43  
69 1 ALA A 655 ? ? -145.04 -157.75 
70 1 ILE A 659 ? ? -38.27  135.68  
71 1 ASN A 662 ? ? -152.99 77.12   
72 1 LEU A 667 ? ? -70.82  -89.73  
73 1 TYR A 668 ? ? -115.50 -72.78  
74 1 PHE A 677 ? ? -98.86  52.38   
75 1 ARG A 683 ? ? 78.44   -103.03 
# 
loop_
_pdbx_validate_peptide_omega.id 
_pdbx_validate_peptide_omega.PDB_model_num 
_pdbx_validate_peptide_omega.auth_comp_id_1 
_pdbx_validate_peptide_omega.auth_asym_id_1 
_pdbx_validate_peptide_omega.auth_seq_id_1 
_pdbx_validate_peptide_omega.PDB_ins_code_1 
_pdbx_validate_peptide_omega.label_alt_id_1 
_pdbx_validate_peptide_omega.auth_comp_id_2 
_pdbx_validate_peptide_omega.auth_asym_id_2 
_pdbx_validate_peptide_omega.auth_seq_id_2 
_pdbx_validate_peptide_omega.PDB_ins_code_2 
_pdbx_validate_peptide_omega.label_alt_id_2 
_pdbx_validate_peptide_omega.omega 
1 1 GLN A 196 ? ? LEU A 197 ? ? 145.36  
2 1 PHE A 404 ? ? ARG A 405 ? ? 147.01  
3 1 THR A 427 ? ? GLU A 428 ? ? 146.25  
4 1 THR A 489 ? ? PRO A 490 ? ? -149.10 
5 1 LEU A 591 ? ? LYS A 592 ? ? 145.59  
6 1 ASP A 593 ? ? GLN A 594 ? ? -149.77 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 180 ? ? 0.081 'SIDE CHAIN' 
2 1 ARG A 321 ? ? 0.119 'SIDE CHAIN' 
3 1 ARG A 649 ? ? 0.124 'SIDE CHAIN' 
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    A 
_pdbx_struct_mod_residue.label_comp_id    PTR 
_pdbx_struct_mod_residue.label_seq_id     727 
_pdbx_struct_mod_residue.auth_asym_id     A 
_pdbx_struct_mod_residue.auth_comp_id     PTR 
_pdbx_struct_mod_residue.auth_seq_id      701 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   TYR 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
_pdbx_point_symmetry.entry_id             8YYV 
_pdbx_point_symmetry.Schoenflies_symbol   C 
_pdbx_point_symmetry.circular_symmetry    2 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8YYV 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         RECIPROCAL 
_em_3d_fitting.ref_protocol      'AB INITIO MODEL' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1BF5 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1BF5 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    8YYV 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'BACK PROJECTION' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.07 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               115824 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 'MULTIPLE SOURCES' COMPLEX 'Dimeric STAT1-DNA complex' ? ? ? '1, 2, 3' 
2 1 RECOMBINANT        COMPLEX STAT1                       ? ? ? 1         
3 1 SYNTHETIC          COMPLEX DNA                         ? ? ? 2,3       
# 
_em_imaging.entry_id                        8YYV 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      0.032 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             18000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           81000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            50 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R0.6/1' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              8YYV 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   4 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8YYV 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              8YYV 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -25 ? A MET 1   
2   1 Y 1 A ASN -24 ? A ASN 2   
3   1 Y 1 A HIS -23 ? A HIS 3   
4   1 Y 1 A LYS -22 ? A LYS 4   
5   1 Y 1 A HIS -21 ? A HIS 5   
6   1 Y 1 A HIS -20 ? A HIS 6   
7   1 Y 1 A HIS -19 ? A HIS 7   
8   1 Y 1 A HIS -18 ? A HIS 8   
9   1 Y 1 A HIS -17 ? A HIS 9   
10  1 Y 1 A HIS -16 ? A HIS 10  
11  1 Y 1 A HIS -15 ? A HIS 11  
12  1 Y 1 A HIS -14 ? A HIS 12  
13  1 Y 1 A HIS -13 ? A HIS 13  
14  1 Y 1 A HIS -12 ? A HIS 14  
15  1 Y 1 A SER -11 ? A SER 15  
16  1 Y 1 A SER -10 ? A SER 16  
17  1 Y 1 A GLY -9  ? A GLY 17  
18  1 Y 1 A GLU -8  ? A GLU 18  
19  1 Y 1 A ASN -7  ? A ASN 19  
20  1 Y 1 A LEU -6  ? A LEU 20  
21  1 Y 1 A TYR -5  ? A TYR 21  
22  1 Y 1 A PHE -4  ? A PHE 22  
23  1 Y 1 A GLN -3  ? A GLN 23  
24  1 Y 1 A GLY -2  ? A GLY 24  
25  1 Y 1 A HIS -1  ? A HIS 25  
26  1 Y 1 A MET 0   ? A MET 26  
27  1 Y 1 A MET 1   ? A MET 27  
28  1 Y 1 A SER 2   ? A SER 28  
29  1 Y 1 A GLN 3   ? A GLN 29  
30  1 Y 1 A TRP 4   ? A TRP 30  
31  1 Y 1 A TYR 5   ? A TYR 31  
32  1 Y 1 A GLU 6   ? A GLU 32  
33  1 Y 1 A LEU 7   ? A LEU 33  
34  1 Y 1 A GLN 8   ? A GLN 34  
35  1 Y 1 A GLN 9   ? A GLN 35  
36  1 Y 1 A LEU 10  ? A LEU 36  
37  1 Y 1 A ASP 11  ? A ASP 37  
38  1 Y 1 A SER 12  ? A SER 38  
39  1 Y 1 A LYS 13  ? A LYS 39  
40  1 Y 1 A PHE 14  ? A PHE 40  
41  1 Y 1 A LEU 15  ? A LEU 41  
42  1 Y 1 A GLU 16  ? A GLU 42  
43  1 Y 1 A GLN 17  ? A GLN 43  
44  1 Y 1 A VAL 18  ? A VAL 44  
45  1 Y 1 A HIS 19  ? A HIS 45  
46  1 Y 1 A GLN 20  ? A GLN 46  
47  1 Y 1 A LEU 21  ? A LEU 47  
48  1 Y 1 A TYR 22  ? A TYR 48  
49  1 Y 1 A ASP 23  ? A ASP 49  
50  1 Y 1 A ASP 24  ? A ASP 50  
51  1 Y 1 A SER 25  ? A SER 51  
52  1 Y 1 A PHE 26  ? A PHE 52  
53  1 Y 1 A PRO 27  ? A PRO 53  
54  1 Y 1 A MET 28  ? A MET 54  
55  1 Y 1 A GLU 29  ? A GLU 55  
56  1 Y 1 A ILE 30  ? A ILE 56  
57  1 Y 1 A ARG 31  ? A ARG 57  
58  1 Y 1 A GLN 32  ? A GLN 58  
59  1 Y 1 A TYR 33  ? A TYR 59  
60  1 Y 1 A LEU 34  ? A LEU 60  
61  1 Y 1 A ALA 35  ? A ALA 61  
62  1 Y 1 A GLN 36  ? A GLN 62  
63  1 Y 1 A TRP 37  ? A TRP 63  
64  1 Y 1 A LEU 38  ? A LEU 64  
65  1 Y 1 A GLU 39  ? A GLU 65  
66  1 Y 1 A LYS 40  ? A LYS 66  
67  1 Y 1 A GLN 41  ? A GLN 67  
68  1 Y 1 A ASP 42  ? A ASP 68  
69  1 Y 1 A TRP 43  ? A TRP 69  
70  1 Y 1 A GLU 44  ? A GLU 70  
71  1 Y 1 A HIS 45  ? A HIS 71  
72  1 Y 1 A ALA 46  ? A ALA 72  
73  1 Y 1 A ALA 47  ? A ALA 73  
74  1 Y 1 A ASN 48  ? A ASN 74  
75  1 Y 1 A ASP 49  ? A ASP 75  
76  1 Y 1 A VAL 50  ? A VAL 76  
77  1 Y 1 A SER 51  ? A SER 77  
78  1 Y 1 A PHE 52  ? A PHE 78  
79  1 Y 1 A ALA 53  ? A ALA 79  
80  1 Y 1 A THR 54  ? A THR 80  
81  1 Y 1 A ILE 55  ? A ILE 81  
82  1 Y 1 A ARG 56  ? A ARG 82  
83  1 Y 1 A PHE 57  ? A PHE 83  
84  1 Y 1 A HIS 58  ? A HIS 84  
85  1 Y 1 A ASP 59  ? A ASP 85  
86  1 Y 1 A LEU 60  ? A LEU 86  
87  1 Y 1 A LEU 61  ? A LEU 87  
88  1 Y 1 A SER 62  ? A SER 88  
89  1 Y 1 A GLN 63  ? A GLN 89  
90  1 Y 1 A LEU 64  ? A LEU 90  
91  1 Y 1 A ASP 65  ? A ASP 91  
92  1 Y 1 A ASP 66  ? A ASP 92  
93  1 Y 1 A GLN 67  ? A GLN 93  
94  1 Y 1 A TYR 68  ? A TYR 94  
95  1 Y 1 A SER 69  ? A SER 95  
96  1 Y 1 A ARG 70  ? A ARG 96  
97  1 Y 1 A PHE 71  ? A PHE 97  
98  1 Y 1 A SER 72  ? A SER 98  
99  1 Y 1 A LEU 73  ? A LEU 99  
100 1 Y 1 A GLU 74  ? A GLU 100 
101 1 Y 1 A ASN 75  ? A ASN 101 
102 1 Y 1 A ASN 76  ? A ASN 102 
103 1 Y 1 A PHE 77  ? A PHE 103 
104 1 Y 1 A LEU 78  ? A LEU 104 
105 1 Y 1 A LEU 79  ? A LEU 105 
106 1 Y 1 A GLN 80  ? A GLN 106 
107 1 Y 1 A HIS 81  ? A HIS 107 
108 1 Y 1 A ASN 82  ? A ASN 108 
109 1 Y 1 A ILE 83  ? A ILE 109 
110 1 Y 1 A ARG 84  ? A ARG 110 
111 1 Y 1 A LYS 85  ? A LYS 111 
112 1 Y 1 A SER 86  ? A SER 112 
113 1 Y 1 A LYS 87  ? A LYS 113 
114 1 Y 1 A ARG 88  ? A ARG 114 
115 1 Y 1 A ASN 89  ? A ASN 115 
116 1 Y 1 A LEU 90  ? A LEU 116 
117 1 Y 1 A GLN 91  ? A GLN 117 
118 1 Y 1 A ASP 92  ? A ASP 118 
119 1 Y 1 A ASN 93  ? A ASN 119 
120 1 Y 1 A PHE 94  ? A PHE 120 
121 1 Y 1 A GLN 95  ? A GLN 121 
122 1 Y 1 A GLU 96  ? A GLU 122 
123 1 Y 1 A ASP 97  ? A ASP 123 
124 1 Y 1 A PRO 98  ? A PRO 124 
125 1 Y 1 A ILE 99  ? A ILE 125 
126 1 Y 1 A GLN 100 ? A GLN 126 
127 1 Y 1 A MET 101 ? A MET 127 
128 1 Y 1 A SER 102 ? A SER 128 
129 1 Y 1 A MET 103 ? A MET 129 
130 1 Y 1 A ILE 104 ? A ILE 130 
131 1 Y 1 A ILE 105 ? A ILE 131 
132 1 Y 1 A TYR 106 ? A TYR 132 
133 1 Y 1 A SER 107 ? A SER 133 
134 1 Y 1 A CYS 108 ? A CYS 134 
135 1 Y 1 A LEU 109 ? A LEU 135 
136 1 Y 1 A LYS 110 ? A LYS 136 
137 1 Y 1 A GLU 111 ? A GLU 137 
138 1 Y 1 A GLU 112 ? A GLU 138 
139 1 Y 1 A ARG 113 ? A ARG 139 
140 1 Y 1 A LYS 114 ? A LYS 140 
141 1 Y 1 A ILE 115 ? A ILE 141 
142 1 Y 1 A LEU 116 ? A LEU 142 
143 1 Y 1 A GLU 117 ? A GLU 143 
144 1 Y 1 A ASN 118 ? A ASN 144 
145 1 Y 1 A ALA 119 ? A ALA 145 
146 1 Y 1 A GLN 120 ? A GLN 146 
147 1 Y 1 A ARG 121 ? A ARG 147 
148 1 Y 1 A PHE 122 ? A PHE 148 
149 1 Y 1 A ASN 123 ? A ASN 149 
150 1 Y 1 A GLN 124 ? A GLN 150 
151 1 Y 1 A ALA 125 ? A ALA 151 
152 1 Y 1 A GLN 126 ? A GLN 152 
153 1 Y 1 A SER 127 ? A SER 153 
154 1 Y 1 A GLY 128 ? A GLY 154 
155 1 Y 1 A ASN 129 ? A ASN 155 
156 1 Y 1 A ILE 130 ? A ILE 156 
157 1 Y 1 A GLN 131 ? A GLN 157 
158 1 Y 1 A SER 132 ? A SER 158 
159 1 Y 1 A THR 133 ? A THR 159 
160 1 Y 1 A VAL 134 ? A VAL 160 
161 1 Y 1 A THR 184 ? A THR 210 
162 1 Y 1 A ASN 185 ? A ASN 211 
163 1 Y 1 A GLY 186 ? A GLY 212 
164 1 Y 1 A VAL 187 ? A VAL 213 
165 1 Y 1 A ALA 188 ? A ALA 214 
166 1 Y 1 A LYS 189 ? A LYS 215 
167 1 Y 1 A SER 190 ? A SER 216 
168 1 Y 1 A ASP 191 ? A ASP 217 
169 1 Y 1 A GLN 192 ? A GLN 218 
170 1 Y 1 A LYS 193 ? A LYS 219 
171 1 Y 1 A LYS 685 ? A LYS 711 
172 1 Y 1 A GLU 686 ? A GLU 712 
173 1 Y 1 A ALA 687 ? A ALA 713 
174 1 Y 1 A PRO 688 ? A PRO 714 
175 1 Y 1 A GLU 689 ? A GLU 715 
176 1 Y 1 A PRO 690 ? A PRO 716 
177 1 Y 1 A MET 691 ? A MET 717 
178 1 Y 1 A GLU 692 ? A GLU 718 
179 1 Y 1 A LEU 693 ? A LEU 719 
180 1 Y 1 A ASP 694 ? A ASP 720 
181 1 Y 1 A GLY 695 ? A GLY 721 
182 1 Y 1 A PRO 696 ? A PRO 722 
183 1 Y 1 A LYS 697 ? A LYS 723 
184 1 Y 1 A GLY 698 ? A GLY 724 
185 1 Y 1 A VAL 712 ? A VAL 738 
186 1 Y 1 A HIS 713 ? A HIS 739 
187 1 Y 1 A PRO 714 ? A PRO 740 
188 1 Y 1 A SER 715 ? A SER 741 
189 1 Y 1 A ARG 716 ? A ARG 742 
190 1 Y 1 A LEU 717 ? A LEU 743 
191 1 Y 1 A GLN 718 ? A GLN 744 
192 1 Y 1 A THR 719 ? A THR 745 
193 1 Y 1 A THR 720 ? A THR 746 
194 1 Y 1 A ASP 721 ? A ASP 747 
195 1 Y 1 A ASN 722 ? A ASN 748 
196 1 Y 1 A LEU 723 ? A LEU 749 
197 1 Y 1 A LEU 724 ? A LEU 750 
198 1 Y 1 A PRO 725 ? A PRO 751 
199 1 Y 1 A MET 726 ? A MET 752 
200 1 Y 1 A SER 727 ? A SER 753 
201 1 Y 1 A PRO 728 ? A PRO 754 
202 1 Y 1 A GLU 729 ? A GLU 755 
203 1 Y 1 A GLU 730 ? A GLU 756 
204 1 Y 1 A PHE 731 ? A PHE 757 
205 1 Y 1 A ASP 732 ? A ASP 758 
206 1 Y 1 A GLU 733 ? A GLU 759 
207 1 Y 1 A VAL 734 ? A VAL 760 
208 1 Y 1 A SER 735 ? A SER 761 
209 1 Y 1 A ARG 736 ? A ARG 762 
210 1 Y 1 A ILE 737 ? A ILE 763 
211 1 Y 1 A VAL 738 ? A VAL 764 
212 1 Y 1 A GLY 739 ? A GLY 765 
213 1 Y 1 A SER 740 ? A SER 766 
214 1 Y 1 A VAL 741 ? A VAL 767 
215 1 Y 1 A GLU 742 ? A GLU 768 
216 1 Y 1 A PHE 743 ? A PHE 769 
217 1 Y 1 A ASP 744 ? A ASP 770 
218 1 Y 1 A SER 745 ? A SER 771 
219 1 Y 1 A MET 746 ? A MET 772 
220 1 Y 1 A MET 747 ? A MET 773 
221 1 Y 1 A ASN 748 ? A ASN 774 
222 1 Y 1 A THR 749 ? A THR 775 
223 1 Y 1 A VAL 750 ? A VAL 776 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ARG N      N N N 14  
ARG CA     C N S 15  
ARG C      C N N 16  
ARG O      O N N 17  
ARG CB     C N N 18  
ARG CG     C N N 19  
ARG CD     C N N 20  
ARG NE     N N N 21  
ARG CZ     C N N 22  
ARG NH1    N N N 23  
ARG NH2    N N N 24  
ARG OXT    O N N 25  
ARG H      H N N 26  
ARG H2     H N N 27  
ARG HA     H N N 28  
ARG HB2    H N N 29  
ARG HB3    H N N 30  
ARG HG2    H N N 31  
ARG HG3    H N N 32  
ARG HD2    H N N 33  
ARG HD3    H N N 34  
ARG HE     H N N 35  
ARG HH11   H N N 36  
ARG HH12   H N N 37  
ARG HH21   H N N 38  
ARG HH22   H N N 39  
ARG HXT    H N N 40  
ASN N      N N N 41  
ASN CA     C N S 42  
ASN C      C N N 43  
ASN O      O N N 44  
ASN CB     C N N 45  
ASN CG     C N N 46  
ASN OD1    O N N 47  
ASN ND2    N N N 48  
ASN OXT    O N N 49  
ASN H      H N N 50  
ASN H2     H N N 51  
ASN HA     H N N 52  
ASN HB2    H N N 53  
ASN HB3    H N N 54  
ASN HD21   H N N 55  
ASN HD22   H N N 56  
ASN HXT    H N N 57  
ASP N      N N N 58  
ASP CA     C N S 59  
ASP C      C N N 60  
ASP O      O N N 61  
ASP CB     C N N 62  
ASP CG     C N N 63  
ASP OD1    O N N 64  
ASP OD2    O N N 65  
ASP OXT    O N N 66  
ASP H      H N N 67  
ASP H2     H N N 68  
ASP HA     H N N 69  
ASP HB2    H N N 70  
ASP HB3    H N N 71  
ASP HD2    H N N 72  
ASP HXT    H N N 73  
CYS N      N N N 74  
CYS CA     C N R 75  
CYS C      C N N 76  
CYS O      O N N 77  
CYS CB     C N N 78  
CYS SG     S N N 79  
CYS OXT    O N N 80  
CYS H      H N N 81  
CYS H2     H N N 82  
CYS HA     H N N 83  
CYS HB2    H N N 84  
CYS HB3    H N N 85  
CYS HG     H N N 86  
CYS HXT    H N N 87  
DA  OP3    O N N 88  
DA  P      P N N 89  
DA  OP1    O N N 90  
DA  OP2    O N N 91  
DA  "O5'"  O N N 92  
DA  "C5'"  C N N 93  
DA  "C4'"  C N R 94  
DA  "O4'"  O N N 95  
DA  "C3'"  C N S 96  
DA  "O3'"  O N N 97  
DA  "C2'"  C N N 98  
DA  "C1'"  C N R 99  
DA  N9     N Y N 100 
DA  C8     C Y N 101 
DA  N7     N Y N 102 
DA  C5     C Y N 103 
DA  C6     C Y N 104 
DA  N6     N N N 105 
DA  N1     N Y N 106 
DA  C2     C Y N 107 
DA  N3     N Y N 108 
DA  C4     C Y N 109 
DA  HOP3   H N N 110 
DA  HOP2   H N N 111 
DA  "H5'"  H N N 112 
DA  "H5''" H N N 113 
DA  "H4'"  H N N 114 
DA  "H3'"  H N N 115 
DA  "HO3'" H N N 116 
DA  "H2'"  H N N 117 
DA  "H2''" H N N 118 
DA  "H1'"  H N N 119 
DA  H8     H N N 120 
DA  H61    H N N 121 
DA  H62    H N N 122 
DA  H2     H N N 123 
DC  OP3    O N N 124 
DC  P      P N N 125 
DC  OP1    O N N 126 
DC  OP2    O N N 127 
DC  "O5'"  O N N 128 
DC  "C5'"  C N N 129 
DC  "C4'"  C N R 130 
DC  "O4'"  O N N 131 
DC  "C3'"  C N S 132 
DC  "O3'"  O N N 133 
DC  "C2'"  C N N 134 
DC  "C1'"  C N R 135 
DC  N1     N N N 136 
DC  C2     C N N 137 
DC  O2     O N N 138 
DC  N3     N N N 139 
DC  C4     C N N 140 
DC  N4     N N N 141 
DC  C5     C N N 142 
DC  C6     C N N 143 
DC  HOP3   H N N 144 
DC  HOP2   H N N 145 
DC  "H5'"  H N N 146 
DC  "H5''" H N N 147 
DC  "H4'"  H N N 148 
DC  "H3'"  H N N 149 
DC  "HO3'" H N N 150 
DC  "H2'"  H N N 151 
DC  "H2''" H N N 152 
DC  "H1'"  H N N 153 
DC  H41    H N N 154 
DC  H42    H N N 155 
DC  H5     H N N 156 
DC  H6     H N N 157 
DG  OP3    O N N 158 
DG  P      P N N 159 
DG  OP1    O N N 160 
DG  OP2    O N N 161 
DG  "O5'"  O N N 162 
DG  "C5'"  C N N 163 
DG  "C4'"  C N R 164 
DG  "O4'"  O N N 165 
DG  "C3'"  C N S 166 
DG  "O3'"  O N N 167 
DG  "C2'"  C N N 168 
DG  "C1'"  C N R 169 
DG  N9     N Y N 170 
DG  C8     C Y N 171 
DG  N7     N Y N 172 
DG  C5     C Y N 173 
DG  C6     C N N 174 
DG  O6     O N N 175 
DG  N1     N N N 176 
DG  C2     C N N 177 
DG  N2     N N N 178 
DG  N3     N N N 179 
DG  C4     C Y N 180 
DG  HOP3   H N N 181 
DG  HOP2   H N N 182 
DG  "H5'"  H N N 183 
DG  "H5''" H N N 184 
DG  "H4'"  H N N 185 
DG  "H3'"  H N N 186 
DG  "HO3'" H N N 187 
DG  "H2'"  H N N 188 
DG  "H2''" H N N 189 
DG  "H1'"  H N N 190 
DG  H8     H N N 191 
DG  H1     H N N 192 
DG  H21    H N N 193 
DG  H22    H N N 194 
DT  OP3    O N N 195 
DT  P      P N N 196 
DT  OP1    O N N 197 
DT  OP2    O N N 198 
DT  "O5'"  O N N 199 
DT  "C5'"  C N N 200 
DT  "C4'"  C N R 201 
DT  "O4'"  O N N 202 
DT  "C3'"  C N S 203 
DT  "O3'"  O N N 204 
DT  "C2'"  C N N 205 
DT  "C1'"  C N R 206 
DT  N1     N N N 207 
DT  C2     C N N 208 
DT  O2     O N N 209 
DT  N3     N N N 210 
DT  C4     C N N 211 
DT  O4     O N N 212 
DT  C5     C N N 213 
DT  C7     C N N 214 
DT  C6     C N N 215 
DT  HOP3   H N N 216 
DT  HOP2   H N N 217 
DT  "H5'"  H N N 218 
DT  "H5''" H N N 219 
DT  "H4'"  H N N 220 
DT  "H3'"  H N N 221 
DT  "HO3'" H N N 222 
DT  "H2'"  H N N 223 
DT  "H2''" H N N 224 
DT  "H1'"  H N N 225 
DT  H3     H N N 226 
DT  H71    H N N 227 
DT  H72    H N N 228 
DT  H73    H N N 229 
DT  H6     H N N 230 
GLN N      N N N 231 
GLN CA     C N S 232 
GLN C      C N N 233 
GLN O      O N N 234 
GLN CB     C N N 235 
GLN CG     C N N 236 
GLN CD     C N N 237 
GLN OE1    O N N 238 
GLN NE2    N N N 239 
GLN OXT    O N N 240 
GLN H      H N N 241 
GLN H2     H N N 242 
GLN HA     H N N 243 
GLN HB2    H N N 244 
GLN HB3    H N N 245 
GLN HG2    H N N 246 
GLN HG3    H N N 247 
GLN HE21   H N N 248 
GLN HE22   H N N 249 
GLN HXT    H N N 250 
GLU N      N N N 251 
GLU CA     C N S 252 
GLU C      C N N 253 
GLU O      O N N 254 
GLU CB     C N N 255 
GLU CG     C N N 256 
GLU CD     C N N 257 
GLU OE1    O N N 258 
GLU OE2    O N N 259 
GLU OXT    O N N 260 
GLU H      H N N 261 
GLU H2     H N N 262 
GLU HA     H N N 263 
GLU HB2    H N N 264 
GLU HB3    H N N 265 
GLU HG2    H N N 266 
GLU HG3    H N N 267 
GLU HE2    H N N 268 
GLU HXT    H N N 269 
GLY N      N N N 270 
GLY CA     C N N 271 
GLY C      C N N 272 
GLY O      O N N 273 
GLY OXT    O N N 274 
GLY H      H N N 275 
GLY H2     H N N 276 
GLY HA2    H N N 277 
GLY HA3    H N N 278 
GLY HXT    H N N 279 
HIS N      N N N 280 
HIS CA     C N S 281 
HIS C      C N N 282 
HIS O      O N N 283 
HIS CB     C N N 284 
HIS CG     C Y N 285 
HIS ND1    N Y N 286 
HIS CD2    C Y N 287 
HIS CE1    C Y N 288 
HIS NE2    N Y N 289 
HIS OXT    O N N 290 
HIS H      H N N 291 
HIS H2     H N N 292 
HIS HA     H N N 293 
HIS HB2    H N N 294 
HIS HB3    H N N 295 
HIS HD1    H N N 296 
HIS HD2    H N N 297 
HIS HE1    H N N 298 
HIS HE2    H N N 299 
HIS HXT    H N N 300 
ILE N      N N N 301 
ILE CA     C N S 302 
ILE C      C N N 303 
ILE O      O N N 304 
ILE CB     C N S 305 
ILE CG1    C N N 306 
ILE CG2    C N N 307 
ILE CD1    C N N 308 
ILE OXT    O N N 309 
ILE H      H N N 310 
ILE H2     H N N 311 
ILE HA     H N N 312 
ILE HB     H N N 313 
ILE HG12   H N N 314 
ILE HG13   H N N 315 
ILE HG21   H N N 316 
ILE HG22   H N N 317 
ILE HG23   H N N 318 
ILE HD11   H N N 319 
ILE HD12   H N N 320 
ILE HD13   H N N 321 
ILE HXT    H N N 322 
LEU N      N N N 323 
LEU CA     C N S 324 
LEU C      C N N 325 
LEU O      O N N 326 
LEU CB     C N N 327 
LEU CG     C N N 328 
LEU CD1    C N N 329 
LEU CD2    C N N 330 
LEU OXT    O N N 331 
LEU H      H N N 332 
LEU H2     H N N 333 
LEU HA     H N N 334 
LEU HB2    H N N 335 
LEU HB3    H N N 336 
LEU HG     H N N 337 
LEU HD11   H N N 338 
LEU HD12   H N N 339 
LEU HD13   H N N 340 
LEU HD21   H N N 341 
LEU HD22   H N N 342 
LEU HD23   H N N 343 
LEU HXT    H N N 344 
LYS N      N N N 345 
LYS CA     C N S 346 
LYS C      C N N 347 
LYS O      O N N 348 
LYS CB     C N N 349 
LYS CG     C N N 350 
LYS CD     C N N 351 
LYS CE     C N N 352 
LYS NZ     N N N 353 
LYS OXT    O N N 354 
LYS H      H N N 355 
LYS H2     H N N 356 
LYS HA     H N N 357 
LYS HB2    H N N 358 
LYS HB3    H N N 359 
LYS HG2    H N N 360 
LYS HG3    H N N 361 
LYS HD2    H N N 362 
LYS HD3    H N N 363 
LYS HE2    H N N 364 
LYS HE3    H N N 365 
LYS HZ1    H N N 366 
LYS HZ2    H N N 367 
LYS HZ3    H N N 368 
LYS HXT    H N N 369 
MET N      N N N 370 
MET CA     C N S 371 
MET C      C N N 372 
MET O      O N N 373 
MET CB     C N N 374 
MET CG     C N N 375 
MET SD     S N N 376 
MET CE     C N N 377 
MET OXT    O N N 378 
MET H      H N N 379 
MET H2     H N N 380 
MET HA     H N N 381 
MET HB2    H N N 382 
MET HB3    H N N 383 
MET HG2    H N N 384 
MET HG3    H N N 385 
MET HE1    H N N 386 
MET HE2    H N N 387 
MET HE3    H N N 388 
MET HXT    H N N 389 
PHE N      N N N 390 
PHE CA     C N S 391 
PHE C      C N N 392 
PHE O      O N N 393 
PHE CB     C N N 394 
PHE CG     C Y N 395 
PHE CD1    C Y N 396 
PHE CD2    C Y N 397 
PHE CE1    C Y N 398 
PHE CE2    C Y N 399 
PHE CZ     C Y N 400 
PHE OXT    O N N 401 
PHE H      H N N 402 
PHE H2     H N N 403 
PHE HA     H N N 404 
PHE HB2    H N N 405 
PHE HB3    H N N 406 
PHE HD1    H N N 407 
PHE HD2    H N N 408 
PHE HE1    H N N 409 
PHE HE2    H N N 410 
PHE HZ     H N N 411 
PHE HXT    H N N 412 
PRO N      N N N 413 
PRO CA     C N S 414 
PRO C      C N N 415 
PRO O      O N N 416 
PRO CB     C N N 417 
PRO CG     C N N 418 
PRO CD     C N N 419 
PRO OXT    O N N 420 
PRO H      H N N 421 
PRO HA     H N N 422 
PRO HB2    H N N 423 
PRO HB3    H N N 424 
PRO HG2    H N N 425 
PRO HG3    H N N 426 
PRO HD2    H N N 427 
PRO HD3    H N N 428 
PRO HXT    H N N 429 
PTR N      N N N 430 
PTR CA     C N S 431 
PTR C      C N N 432 
PTR O      O N N 433 
PTR OXT    O N N 434 
PTR CB     C N N 435 
PTR CG     C Y N 436 
PTR CD1    C Y N 437 
PTR CD2    C Y N 438 
PTR CE1    C Y N 439 
PTR CE2    C Y N 440 
PTR CZ     C Y N 441 
PTR OH     O N N 442 
PTR P      P N N 443 
PTR O1P    O N N 444 
PTR O2P    O N N 445 
PTR O3P    O N N 446 
PTR H      H N N 447 
PTR H2     H N N 448 
PTR HA     H N N 449 
PTR HXT    H N N 450 
PTR HB2    H N N 451 
PTR HB3    H N N 452 
PTR HD1    H N N 453 
PTR HD2    H N N 454 
PTR HE1    H N N 455 
PTR HE2    H N N 456 
PTR HO2P   H N N 457 
PTR HO3P   H N N 458 
SER N      N N N 459 
SER CA     C N S 460 
SER C      C N N 461 
SER O      O N N 462 
SER CB     C N N 463 
SER OG     O N N 464 
SER OXT    O N N 465 
SER H      H N N 466 
SER H2     H N N 467 
SER HA     H N N 468 
SER HB2    H N N 469 
SER HB3    H N N 470 
SER HG     H N N 471 
SER HXT    H N N 472 
THR N      N N N 473 
THR CA     C N S 474 
THR C      C N N 475 
THR O      O N N 476 
THR CB     C N R 477 
THR OG1    O N N 478 
THR CG2    C N N 479 
THR OXT    O N N 480 
THR H      H N N 481 
THR H2     H N N 482 
THR HA     H N N 483 
THR HB     H N N 484 
THR HG1    H N N 485 
THR HG21   H N N 486 
THR HG22   H N N 487 
THR HG23   H N N 488 
THR HXT    H N N 489 
TRP N      N N N 490 
TRP CA     C N S 491 
TRP C      C N N 492 
TRP O      O N N 493 
TRP CB     C N N 494 
TRP CG     C Y N 495 
TRP CD1    C Y N 496 
TRP CD2    C Y N 497 
TRP NE1    N Y N 498 
TRP CE2    C Y N 499 
TRP CE3    C Y N 500 
TRP CZ2    C Y N 501 
TRP CZ3    C Y N 502 
TRP CH2    C Y N 503 
TRP OXT    O N N 504 
TRP H      H N N 505 
TRP H2     H N N 506 
TRP HA     H N N 507 
TRP HB2    H N N 508 
TRP HB3    H N N 509 
TRP HD1    H N N 510 
TRP HE1    H N N 511 
TRP HE3    H N N 512 
TRP HZ2    H N N 513 
TRP HZ3    H N N 514 
TRP HH2    H N N 515 
TRP HXT    H N N 516 
TYR N      N N N 517 
TYR CA     C N S 518 
TYR C      C N N 519 
TYR O      O N N 520 
TYR CB     C N N 521 
TYR CG     C Y N 522 
TYR CD1    C Y N 523 
TYR CD2    C Y N 524 
TYR CE1    C Y N 525 
TYR CE2    C Y N 526 
TYR CZ     C Y N 527 
TYR OH     O N N 528 
TYR OXT    O N N 529 
TYR H      H N N 530 
TYR H2     H N N 531 
TYR HA     H N N 532 
TYR HB2    H N N 533 
TYR HB3    H N N 534 
TYR HD1    H N N 535 
TYR HD2    H N N 536 
TYR HE1    H N N 537 
TYR HE2    H N N 538 
TYR HH     H N N 539 
TYR HXT    H N N 540 
VAL N      N N N 541 
VAL CA     C N S 542 
VAL C      C N N 543 
VAL O      O N N 544 
VAL CB     C N N 545 
VAL CG1    C N N 546 
VAL CG2    C N N 547 
VAL OXT    O N N 548 
VAL H      H N N 549 
VAL H2     H N N 550 
VAL HA     H N N 551 
VAL HB     H N N 552 
VAL HG11   H N N 553 
VAL HG12   H N N 554 
VAL HG13   H N N 555 
VAL HG21   H N N 556 
VAL HG22   H N N 557 
VAL HG23   H N N 558 
VAL HXT    H N N 559 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
DA  OP3   P      sing N N 83  
DA  OP3   HOP3   sing N N 84  
DA  P     OP1    doub N N 85  
DA  P     OP2    sing N N 86  
DA  P     "O5'"  sing N N 87  
DA  OP2   HOP2   sing N N 88  
DA  "O5'" "C5'"  sing N N 89  
DA  "C5'" "C4'"  sing N N 90  
DA  "C5'" "H5'"  sing N N 91  
DA  "C5'" "H5''" sing N N 92  
DA  "C4'" "O4'"  sing N N 93  
DA  "C4'" "C3'"  sing N N 94  
DA  "C4'" "H4'"  sing N N 95  
DA  "O4'" "C1'"  sing N N 96  
DA  "C3'" "O3'"  sing N N 97  
DA  "C3'" "C2'"  sing N N 98  
DA  "C3'" "H3'"  sing N N 99  
DA  "O3'" "HO3'" sing N N 100 
DA  "C2'" "C1'"  sing N N 101 
DA  "C2'" "H2'"  sing N N 102 
DA  "C2'" "H2''" sing N N 103 
DA  "C1'" N9     sing N N 104 
DA  "C1'" "H1'"  sing N N 105 
DA  N9    C8     sing Y N 106 
DA  N9    C4     sing Y N 107 
DA  C8    N7     doub Y N 108 
DA  C8    H8     sing N N 109 
DA  N7    C5     sing Y N 110 
DA  C5    C6     sing Y N 111 
DA  C5    C4     doub Y N 112 
DA  C6    N6     sing N N 113 
DA  C6    N1     doub Y N 114 
DA  N6    H61    sing N N 115 
DA  N6    H62    sing N N 116 
DA  N1    C2     sing Y N 117 
DA  C2    N3     doub Y N 118 
DA  C2    H2     sing N N 119 
DA  N3    C4     sing Y N 120 
DC  OP3   P      sing N N 121 
DC  OP3   HOP3   sing N N 122 
DC  P     OP1    doub N N 123 
DC  P     OP2    sing N N 124 
DC  P     "O5'"  sing N N 125 
DC  OP2   HOP2   sing N N 126 
DC  "O5'" "C5'"  sing N N 127 
DC  "C5'" "C4'"  sing N N 128 
DC  "C5'" "H5'"  sing N N 129 
DC  "C5'" "H5''" sing N N 130 
DC  "C4'" "O4'"  sing N N 131 
DC  "C4'" "C3'"  sing N N 132 
DC  "C4'" "H4'"  sing N N 133 
DC  "O4'" "C1'"  sing N N 134 
DC  "C3'" "O3'"  sing N N 135 
DC  "C3'" "C2'"  sing N N 136 
DC  "C3'" "H3'"  sing N N 137 
DC  "O3'" "HO3'" sing N N 138 
DC  "C2'" "C1'"  sing N N 139 
DC  "C2'" "H2'"  sing N N 140 
DC  "C2'" "H2''" sing N N 141 
DC  "C1'" N1     sing N N 142 
DC  "C1'" "H1'"  sing N N 143 
DC  N1    C2     sing N N 144 
DC  N1    C6     sing N N 145 
DC  C2    O2     doub N N 146 
DC  C2    N3     sing N N 147 
DC  N3    C4     doub N N 148 
DC  C4    N4     sing N N 149 
DC  C4    C5     sing N N 150 
DC  N4    H41    sing N N 151 
DC  N4    H42    sing N N 152 
DC  C5    C6     doub N N 153 
DC  C5    H5     sing N N 154 
DC  C6    H6     sing N N 155 
DG  OP3   P      sing N N 156 
DG  OP3   HOP3   sing N N 157 
DG  P     OP1    doub N N 158 
DG  P     OP2    sing N N 159 
DG  P     "O5'"  sing N N 160 
DG  OP2   HOP2   sing N N 161 
DG  "O5'" "C5'"  sing N N 162 
DG  "C5'" "C4'"  sing N N 163 
DG  "C5'" "H5'"  sing N N 164 
DG  "C5'" "H5''" sing N N 165 
DG  "C4'" "O4'"  sing N N 166 
DG  "C4'" "C3'"  sing N N 167 
DG  "C4'" "H4'"  sing N N 168 
DG  "O4'" "C1'"  sing N N 169 
DG  "C3'" "O3'"  sing N N 170 
DG  "C3'" "C2'"  sing N N 171 
DG  "C3'" "H3'"  sing N N 172 
DG  "O3'" "HO3'" sing N N 173 
DG  "C2'" "C1'"  sing N N 174 
DG  "C2'" "H2'"  sing N N 175 
DG  "C2'" "H2''" sing N N 176 
DG  "C1'" N9     sing N N 177 
DG  "C1'" "H1'"  sing N N 178 
DG  N9    C8     sing Y N 179 
DG  N9    C4     sing Y N 180 
DG  C8    N7     doub Y N 181 
DG  C8    H8     sing N N 182 
DG  N7    C5     sing Y N 183 
DG  C5    C6     sing N N 184 
DG  C5    C4     doub Y N 185 
DG  C6    O6     doub N N 186 
DG  C6    N1     sing N N 187 
DG  N1    C2     sing N N 188 
DG  N1    H1     sing N N 189 
DG  C2    N2     sing N N 190 
DG  C2    N3     doub N N 191 
DG  N2    H21    sing N N 192 
DG  N2    H22    sing N N 193 
DG  N3    C4     sing N N 194 
DT  OP3   P      sing N N 195 
DT  OP3   HOP3   sing N N 196 
DT  P     OP1    doub N N 197 
DT  P     OP2    sing N N 198 
DT  P     "O5'"  sing N N 199 
DT  OP2   HOP2   sing N N 200 
DT  "O5'" "C5'"  sing N N 201 
DT  "C5'" "C4'"  sing N N 202 
DT  "C5'" "H5'"  sing N N 203 
DT  "C5'" "H5''" sing N N 204 
DT  "C4'" "O4'"  sing N N 205 
DT  "C4'" "C3'"  sing N N 206 
DT  "C4'" "H4'"  sing N N 207 
DT  "O4'" "C1'"  sing N N 208 
DT  "C3'" "O3'"  sing N N 209 
DT  "C3'" "C2'"  sing N N 210 
DT  "C3'" "H3'"  sing N N 211 
DT  "O3'" "HO3'" sing N N 212 
DT  "C2'" "C1'"  sing N N 213 
DT  "C2'" "H2'"  sing N N 214 
DT  "C2'" "H2''" sing N N 215 
DT  "C1'" N1     sing N N 216 
DT  "C1'" "H1'"  sing N N 217 
DT  N1    C2     sing N N 218 
DT  N1    C6     sing N N 219 
DT  C2    O2     doub N N 220 
DT  C2    N3     sing N N 221 
DT  N3    C4     sing N N 222 
DT  N3    H3     sing N N 223 
DT  C4    O4     doub N N 224 
DT  C4    C5     sing N N 225 
DT  C5    C7     sing N N 226 
DT  C5    C6     doub N N 227 
DT  C7    H71    sing N N 228 
DT  C7    H72    sing N N 229 
DT  C7    H73    sing N N 230 
DT  C6    H6     sing N N 231 
GLN N     CA     sing N N 232 
GLN N     H      sing N N 233 
GLN N     H2     sing N N 234 
GLN CA    C      sing N N 235 
GLN CA    CB     sing N N 236 
GLN CA    HA     sing N N 237 
GLN C     O      doub N N 238 
GLN C     OXT    sing N N 239 
GLN CB    CG     sing N N 240 
GLN CB    HB2    sing N N 241 
GLN CB    HB3    sing N N 242 
GLN CG    CD     sing N N 243 
GLN CG    HG2    sing N N 244 
GLN CG    HG3    sing N N 245 
GLN CD    OE1    doub N N 246 
GLN CD    NE2    sing N N 247 
GLN NE2   HE21   sing N N 248 
GLN NE2   HE22   sing N N 249 
GLN OXT   HXT    sing N N 250 
GLU N     CA     sing N N 251 
GLU N     H      sing N N 252 
GLU N     H2     sing N N 253 
GLU CA    C      sing N N 254 
GLU CA    CB     sing N N 255 
GLU CA    HA     sing N N 256 
GLU C     O      doub N N 257 
GLU C     OXT    sing N N 258 
GLU CB    CG     sing N N 259 
GLU CB    HB2    sing N N 260 
GLU CB    HB3    sing N N 261 
GLU CG    CD     sing N N 262 
GLU CG    HG2    sing N N 263 
GLU CG    HG3    sing N N 264 
GLU CD    OE1    doub N N 265 
GLU CD    OE2    sing N N 266 
GLU OE2   HE2    sing N N 267 
GLU OXT   HXT    sing N N 268 
GLY N     CA     sing N N 269 
GLY N     H      sing N N 270 
GLY N     H2     sing N N 271 
GLY CA    C      sing N N 272 
GLY CA    HA2    sing N N 273 
GLY CA    HA3    sing N N 274 
GLY C     O      doub N N 275 
GLY C     OXT    sing N N 276 
GLY OXT   HXT    sing N N 277 
HIS N     CA     sing N N 278 
HIS N     H      sing N N 279 
HIS N     H2     sing N N 280 
HIS CA    C      sing N N 281 
HIS CA    CB     sing N N 282 
HIS CA    HA     sing N N 283 
HIS C     O      doub N N 284 
HIS C     OXT    sing N N 285 
HIS CB    CG     sing N N 286 
HIS CB    HB2    sing N N 287 
HIS CB    HB3    sing N N 288 
HIS CG    ND1    sing Y N 289 
HIS CG    CD2    doub Y N 290 
HIS ND1   CE1    doub Y N 291 
HIS ND1   HD1    sing N N 292 
HIS CD2   NE2    sing Y N 293 
HIS CD2   HD2    sing N N 294 
HIS CE1   NE2    sing Y N 295 
HIS CE1   HE1    sing N N 296 
HIS NE2   HE2    sing N N 297 
HIS OXT   HXT    sing N N 298 
ILE N     CA     sing N N 299 
ILE N     H      sing N N 300 
ILE N     H2     sing N N 301 
ILE CA    C      sing N N 302 
ILE CA    CB     sing N N 303 
ILE CA    HA     sing N N 304 
ILE C     O      doub N N 305 
ILE C     OXT    sing N N 306 
ILE CB    CG1    sing N N 307 
ILE CB    CG2    sing N N 308 
ILE CB    HB     sing N N 309 
ILE CG1   CD1    sing N N 310 
ILE CG1   HG12   sing N N 311 
ILE CG1   HG13   sing N N 312 
ILE CG2   HG21   sing N N 313 
ILE CG2   HG22   sing N N 314 
ILE CG2   HG23   sing N N 315 
ILE CD1   HD11   sing N N 316 
ILE CD1   HD12   sing N N 317 
ILE CD1   HD13   sing N N 318 
ILE OXT   HXT    sing N N 319 
LEU N     CA     sing N N 320 
LEU N     H      sing N N 321 
LEU N     H2     sing N N 322 
LEU CA    C      sing N N 323 
LEU CA    CB     sing N N 324 
LEU CA    HA     sing N N 325 
LEU C     O      doub N N 326 
LEU C     OXT    sing N N 327 
LEU CB    CG     sing N N 328 
LEU CB    HB2    sing N N 329 
LEU CB    HB3    sing N N 330 
LEU CG    CD1    sing N N 331 
LEU CG    CD2    sing N N 332 
LEU CG    HG     sing N N 333 
LEU CD1   HD11   sing N N 334 
LEU CD1   HD12   sing N N 335 
LEU CD1   HD13   sing N N 336 
LEU CD2   HD21   sing N N 337 
LEU CD2   HD22   sing N N 338 
LEU CD2   HD23   sing N N 339 
LEU OXT   HXT    sing N N 340 
LYS N     CA     sing N N 341 
LYS N     H      sing N N 342 
LYS N     H2     sing N N 343 
LYS CA    C      sing N N 344 
LYS CA    CB     sing N N 345 
LYS CA    HA     sing N N 346 
LYS C     O      doub N N 347 
LYS C     OXT    sing N N 348 
LYS CB    CG     sing N N 349 
LYS CB    HB2    sing N N 350 
LYS CB    HB3    sing N N 351 
LYS CG    CD     sing N N 352 
LYS CG    HG2    sing N N 353 
LYS CG    HG3    sing N N 354 
LYS CD    CE     sing N N 355 
LYS CD    HD2    sing N N 356 
LYS CD    HD3    sing N N 357 
LYS CE    NZ     sing N N 358 
LYS CE    HE2    sing N N 359 
LYS CE    HE3    sing N N 360 
LYS NZ    HZ1    sing N N 361 
LYS NZ    HZ2    sing N N 362 
LYS NZ    HZ3    sing N N 363 
LYS OXT   HXT    sing N N 364 
MET N     CA     sing N N 365 
MET N     H      sing N N 366 
MET N     H2     sing N N 367 
MET CA    C      sing N N 368 
MET CA    CB     sing N N 369 
MET CA    HA     sing N N 370 
MET C     O      doub N N 371 
MET C     OXT    sing N N 372 
MET CB    CG     sing N N 373 
MET CB    HB2    sing N N 374 
MET CB    HB3    sing N N 375 
MET CG    SD     sing N N 376 
MET CG    HG2    sing N N 377 
MET CG    HG3    sing N N 378 
MET SD    CE     sing N N 379 
MET CE    HE1    sing N N 380 
MET CE    HE2    sing N N 381 
MET CE    HE3    sing N N 382 
MET OXT   HXT    sing N N 383 
PHE N     CA     sing N N 384 
PHE N     H      sing N N 385 
PHE N     H2     sing N N 386 
PHE CA    C      sing N N 387 
PHE CA    CB     sing N N 388 
PHE CA    HA     sing N N 389 
PHE C     O      doub N N 390 
PHE C     OXT    sing N N 391 
PHE CB    CG     sing N N 392 
PHE CB    HB2    sing N N 393 
PHE CB    HB3    sing N N 394 
PHE CG    CD1    doub Y N 395 
PHE CG    CD2    sing Y N 396 
PHE CD1   CE1    sing Y N 397 
PHE CD1   HD1    sing N N 398 
PHE CD2   CE2    doub Y N 399 
PHE CD2   HD2    sing N N 400 
PHE CE1   CZ     doub Y N 401 
PHE CE1   HE1    sing N N 402 
PHE CE2   CZ     sing Y N 403 
PHE CE2   HE2    sing N N 404 
PHE CZ    HZ     sing N N 405 
PHE OXT   HXT    sing N N 406 
PRO N     CA     sing N N 407 
PRO N     CD     sing N N 408 
PRO N     H      sing N N 409 
PRO CA    C      sing N N 410 
PRO CA    CB     sing N N 411 
PRO CA    HA     sing N N 412 
PRO C     O      doub N N 413 
PRO C     OXT    sing N N 414 
PRO CB    CG     sing N N 415 
PRO CB    HB2    sing N N 416 
PRO CB    HB3    sing N N 417 
PRO CG    CD     sing N N 418 
PRO CG    HG2    sing N N 419 
PRO CG    HG3    sing N N 420 
PRO CD    HD2    sing N N 421 
PRO CD    HD3    sing N N 422 
PRO OXT   HXT    sing N N 423 
PTR N     CA     sing N N 424 
PTR N     H      sing N N 425 
PTR N     H2     sing N N 426 
PTR CA    C      sing N N 427 
PTR CA    CB     sing N N 428 
PTR CA    HA     sing N N 429 
PTR C     O      doub N N 430 
PTR C     OXT    sing N N 431 
PTR OXT   HXT    sing N N 432 
PTR CB    CG     sing N N 433 
PTR CB    HB2    sing N N 434 
PTR CB    HB3    sing N N 435 
PTR CG    CD1    doub Y N 436 
PTR CG    CD2    sing Y N 437 
PTR CD1   CE1    sing Y N 438 
PTR CD1   HD1    sing N N 439 
PTR CD2   CE2    doub Y N 440 
PTR CD2   HD2    sing N N 441 
PTR CE1   CZ     doub Y N 442 
PTR CE1   HE1    sing N N 443 
PTR CE2   CZ     sing Y N 444 
PTR CE2   HE2    sing N N 445 
PTR CZ    OH     sing N N 446 
PTR OH    P      sing N N 447 
PTR P     O1P    doub N N 448 
PTR P     O2P    sing N N 449 
PTR P     O3P    sing N N 450 
PTR O2P   HO2P   sing N N 451 
PTR O3P   HO3P   sing N N 452 
SER N     CA     sing N N 453 
SER N     H      sing N N 454 
SER N     H2     sing N N 455 
SER CA    C      sing N N 456 
SER CA    CB     sing N N 457 
SER CA    HA     sing N N 458 
SER C     O      doub N N 459 
SER C     OXT    sing N N 460 
SER CB    OG     sing N N 461 
SER CB    HB2    sing N N 462 
SER CB    HB3    sing N N 463 
SER OG    HG     sing N N 464 
SER OXT   HXT    sing N N 465 
THR N     CA     sing N N 466 
THR N     H      sing N N 467 
THR N     H2     sing N N 468 
THR CA    C      sing N N 469 
THR CA    CB     sing N N 470 
THR CA    HA     sing N N 471 
THR C     O      doub N N 472 
THR C     OXT    sing N N 473 
THR CB    OG1    sing N N 474 
THR CB    CG2    sing N N 475 
THR CB    HB     sing N N 476 
THR OG1   HG1    sing N N 477 
THR CG2   HG21   sing N N 478 
THR CG2   HG22   sing N N 479 
THR CG2   HG23   sing N N 480 
THR OXT   HXT    sing N N 481 
TRP N     CA     sing N N 482 
TRP N     H      sing N N 483 
TRP N     H2     sing N N 484 
TRP CA    C      sing N N 485 
TRP CA    CB     sing N N 486 
TRP CA    HA     sing N N 487 
TRP C     O      doub N N 488 
TRP C     OXT    sing N N 489 
TRP CB    CG     sing N N 490 
TRP CB    HB2    sing N N 491 
TRP CB    HB3    sing N N 492 
TRP CG    CD1    doub Y N 493 
TRP CG    CD2    sing Y N 494 
TRP CD1   NE1    sing Y N 495 
TRP CD1   HD1    sing N N 496 
TRP CD2   CE2    doub Y N 497 
TRP CD2   CE3    sing Y N 498 
TRP NE1   CE2    sing Y N 499 
TRP NE1   HE1    sing N N 500 
TRP CE2   CZ2    sing Y N 501 
TRP CE3   CZ3    doub Y N 502 
TRP CE3   HE3    sing N N 503 
TRP CZ2   CH2    doub Y N 504 
TRP CZ2   HZ2    sing N N 505 
TRP CZ3   CH2    sing Y N 506 
TRP CZ3   HZ3    sing N N 507 
TRP CH2   HH2    sing N N 508 
TRP OXT   HXT    sing N N 509 
TYR N     CA     sing N N 510 
TYR N     H      sing N N 511 
TYR N     H2     sing N N 512 
TYR CA    C      sing N N 513 
TYR CA    CB     sing N N 514 
TYR CA    HA     sing N N 515 
TYR C     O      doub N N 516 
TYR C     OXT    sing N N 517 
TYR CB    CG     sing N N 518 
TYR CB    HB2    sing N N 519 
TYR CB    HB3    sing N N 520 
TYR CG    CD1    doub Y N 521 
TYR CG    CD2    sing Y N 522 
TYR CD1   CE1    sing Y N 523 
TYR CD1   HD1    sing N N 524 
TYR CD2   CE2    doub Y N 525 
TYR CD2   HD2    sing N N 526 
TYR CE1   CZ     doub Y N 527 
TYR CE1   HE1    sing N N 528 
TYR CE2   CZ     sing Y N 529 
TYR CE2   HE2    sing N N 530 
TYR CZ    OH     sing N N 531 
TYR OH    HH     sing N N 532 
TYR OXT   HXT    sing N N 533 
VAL N     CA     sing N N 534 
VAL N     H      sing N N 535 
VAL N     H2     sing N N 536 
VAL CA    C      sing N N 537 
VAL CA    CB     sing N N 538 
VAL CA    HA     sing N N 539 
VAL C     O      doub N N 540 
VAL C     OXT    sing N N 541 
VAL CB    CG1    sing N N 542 
VAL CB    CG2    sing N N 543 
VAL CB    HB     sing N N 544 
VAL CG1   HG11   sing N N 545 
VAL CG1   HG12   sing N N 546 
VAL CG1   HG13   sing N N 547 
VAL CG2   HG21   sing N N 548 
VAL CG2   HG22   sing N N 549 
VAL CG2   HG23   sing N N 550 
VAL OXT   HXT    sing N N 551 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-04-04 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           8YYV 
_em_admin.last_update        2025-03-26 
_em_admin.map_release_date   2025-03-26 
_em_admin.title              'A dimeric STAT1-DNA complex' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   2 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          469008 
_em_entity_assembly_recombinant.organism             'Escherichia coli BL21(DE3)' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_entity_assembly_synthetic.cell                 ? 
_em_entity_assembly_synthetic.cellular_location    ? 
_em_entity_assembly_synthetic.entity_assembly_id   3 
_em_entity_assembly_synthetic.id                   1 
_em_entity_assembly_synthetic.ncbi_tax_id          32630 
_em_entity_assembly_synthetic.organ                ? 
_em_entity_assembly_synthetic.organelle            ? 
_em_entity_assembly_synthetic.organism             'synthetic construct' 
_em_entity_assembly_synthetic.strain               ? 
_em_entity_assembly_synthetic.tissue               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'GIF Bioquantum' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   'A Cs corrector (CEOS GmbH, Germany)' 
_em_imaging_optics.details                    ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   4005846 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ?                       1  1 ? ? cryoSPARC       ? 
'IMAGE ACQUISITION'             ?                       2  ? ? 1 SerialEM        ? 
MASKING                         ?                       3  ? ? ? ?               ? 
'CTF CORRECTION'                ?                       4  1 ? ? cryoSPARC       ? 
'LAYERLINE INDEXING'            ?                       5  ? ? ? ?               ? 
'DIFFRACTION INDEXING'          ?                       6  ? ? ? ?               ? 
'MODEL FITTING'                 ?                       7  ? 1 ? 'UCSF ChimeraX' ? 
'MODEL FITTING'                 ?                       8  ? 1 ? Coot            ? 
OTHER                           ?                       9  ? ? ? ?               ? 
'INITIAL EULER ASSIGNMENT'      ?                       10 1 ? ? cryoSPARC       ? 
'FINAL EULER ASSIGNMENT'        ?                       11 1 ? ? cryoSPARC       ? 
CLASSIFICATION                  ?                       12 1 ? ? cryoSPARC       ? 
RECONSTRUCTION                  ?                       13 1 ? ? cryoSPARC       ? 
'MODEL REFINEMENT'              'real space refinement' 14 ? 1 ? PHENIX          ? 
'MODEL REFINEMENT'              ?                       15 ? 1 ? Servalcat       ? 
'VOLUME SELECTION'              ?                       16 1 1 1 ?               ? 
'SERIES ALIGNMENT'              ?                       17 1 1 1 ?               ? 
'MOLECULAR REPLACEMENT'         ?                       18 1 1 1 ?               ? 
'LATTICE DISTORTION CORRECTION' ?                       19 1 1 1 ?               ? 
'SYMMETRY DETERMINATION'        ?                       20 1 1 1 ?               ? 
'CRYSTALLOGRAPHY MERGING'       ?                       21 1 1 1 ?               ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
8YYV 'double helix'        
8YYV 'b-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B DC 2  1_555 C DG 18 1_555 0.259  -0.226 -0.160 -2.469  -15.787 3.540  1  C_DC2:DG18_B  C 2  ? B 18 ? 19 1 
1 B DA 3  1_555 C DT 17 1_555 -0.300 -0.111 -0.244 1.919   -0.975  -3.197 2  C_DA3:DT17_B  C 3  ? B 17 ? 20 1 
1 B DG 4  1_555 C DC 16 1_555 -0.699 -0.302 0.073  7.063   -2.207  1.122  3  C_DG4:DC16_B  C 4  ? B 16 ? 19 1 
1 B DT 5  1_555 C DA 15 1_555 -0.511 -0.062 0.793  -9.017  -2.541  -5.549 4  C_DT5:DA15_B  C 5  ? B 15 ? 20 1 
1 B DT 6  1_555 C DA 14 1_555 0.004  -0.012 0.514  -0.150  0.341   0.780  5  C_DT6:DA14_B  C 6  ? B 14 ? 20 1 
1 B DT 7  1_555 C DA 13 1_555 -0.080 -0.263 0.049  -1.023  -2.856  0.132  6  C_DT7:DA13_B  C 7  ? B 13 ? 20 1 
1 B DC 8  1_555 C DG 12 1_555 -0.292 -0.176 0.326  -17.794 0.075   -4.193 7  C_DC8:DG12_B  C 8  ? B 12 ? 19 1 
1 B DC 9  1_555 C DG 11 1_555 -0.145 -0.142 -0.163 -1.764  5.139   -4.165 8  C_DC9:DG11_B  C 9  ? B 11 ? 19 1 
1 B DC 10 1_555 C DG 10 1_555 0.191  -0.120 0.554  -16.659 4.555   2.631  9  C_DC10:DG10_B C 10 ? B 10 ? 19 1 
1 B DG 11 1_555 C DC 9  1_555 0.076  -0.155 -0.277 -1.131  2.845   -4.902 10 C_DG11:DC9_B  C 11 ? B 9  ? 19 1 
1 B DT 12 1_555 C DA 8  1_555 -0.014 -0.069 0.269  -3.677  -4.017  -1.318 11 C_DT12:DA8_B  C 12 ? B 8  ? 20 1 
1 B DA 13 1_555 C DT 7  1_555 0.046  -0.230 -0.027 -3.958  -6.074  1.633  12 C_DA13:DT7_B  C 13 ? B 7  ? 20 1 
1 B DA 14 1_555 C DT 6  1_555 -0.032 -0.020 0.488  1.971   0.794   0.856  13 C_DA14:DT6_B  C 14 ? B 6  ? 20 1 
1 B DA 15 1_555 C DT 5  1_555 0.542  -0.080 0.833  10.784  -2.498  -5.536 14 C_DA15:DT5_B  C 15 ? B 5  ? 20 1 
1 B DT 16 1_555 C DA 4  1_555 0.466  -0.248 0.125  3.024   -2.649  6.125  15 C_DT16:DA4_B  C 16 ? B 4  ? 20 1 
1 B DG 17 1_555 C DC 3  1_555 0.084  -0.085 0.147  -4.918  -2.441  -0.497 16 C_DG17:DC3_B  C 17 ? B 3  ? 19 1 
1 B DC 18 1_555 C DG 2  1_555 1.031  -0.226 -0.253 -7.064  -8.055  3.250  17 C_DC18:DG2_B  C 18 ? B 2  ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B DC 2  1_555 C DG 18 1_555 B DA 3  1_555 C DT 17 1_555 0.107  0.695  3.305 -1.595 0.781  32.742 1.096  -0.468 3.312 1.385   
2.828   32.789 1  CC_DC2DA3:DT17DG18_BB  C 2  ? B 18 ? C 3  ? B 17 ? 
1 B DA 3  1_555 C DT 17 1_555 B DG 4  1_555 C DC 16 1_555 0.152  0.504  3.147 -2.284 3.514  32.497 0.307  -0.650 3.165 6.247   
4.060   32.759 2  CC_DA3DG4:DC16DT17_BB  C 3  ? B 17 ? C 4  ? B 16 ? 
1 B DG 4  1_555 C DC 16 1_555 B DT 5  1_555 C DA 15 1_555 -0.038 -0.581 3.735 -5.007 6.211  35.306 -1.924 -0.736 3.558 10.082  
8.128   36.168 3  CC_DG4DT5:DA15DC16_BB  C 4  ? B 16 ? C 5  ? B 15 ? 
1 B DT 5  1_555 C DA 15 1_555 B DT 6  1_555 C DA 14 1_555 -0.025 -0.422 3.048 0.662  -8.885 38.603 0.364  0.111  3.066 -13.226 
-0.985  39.580 4  CC_DT5DT6:DA14DA15_BB  C 5  ? B 15 ? C 6  ? B 14 ? 
1 B DT 6  1_555 C DA 14 1_555 B DT 7  1_555 C DA 13 1_555 -0.178 0.005  3.219 2.256  -4.787 38.653 0.576  0.534  3.181 -7.191  
-3.389  39.000 5  CC_DT6DT7:DA13DA14_BB  C 6  ? B 14 ? C 7  ? B 13 ? 
1 B DT 7  1_555 C DA 13 1_555 B DC 8  1_555 C DG 12 1_555 -0.561 -0.087 3.745 -5.962 7.879  32.909 -1.579 -0.132 3.671 13.533  
10.239  34.321 6  CC_DT7DC8:DG12DA13_BB  C 7  ? B 13 ? C 8  ? B 12 ? 
1 B DC 8  1_555 C DG 12 1_555 B DC 9  1_555 C DG 11 1_555 -0.069 0.061  2.922 0.349  -3.382 33.290 0.604  0.171  2.901 -5.885  
-0.608  33.459 7  CC_DC8DC9:DG11DG12_BB  C 8  ? B 12 ? C 9  ? B 11 ? 
1 B DC 9  1_555 C DG 11 1_555 B DC 10 1_555 C DG 10 1_555 -0.357 0.348  3.799 -6.831 6.812  36.948 -0.485 -0.475 3.806 10.529  
10.559  38.144 8  CC_DC9DC10:DG10DG11_BB C 9  ? B 11 ? C 10 ? B 10 ? 
1 B DC 10 1_555 C DG 10 1_555 B DG 11 1_555 C DC 9  1_555 0.058  0.342  2.865 4.812  0.902  36.066 0.437  0.496  2.856 1.449   
-7.728  36.386 9  CC_DC10DG11:DC9DG10_BB C 10 ? B 10 ? C 11 ? B 9  ? 
1 B DG 11 1_555 C DC 9  1_555 B DT 12 1_555 C DA 8  1_555 -0.183 -0.052 3.429 -4.150 4.564  33.194 -0.867 -0.392 3.389 7.904   
7.188   33.746 10 CC_DG11DT12:DA8DC9_BB  C 11 ? B 9  ? C 12 ? B 8  ? 
1 B DT 12 1_555 C DA 8  1_555 B DA 13 1_555 C DT 7  1_555 0.341  0.147  3.264 2.983  2.585  33.162 -0.175 -0.097 3.283 4.509   
-5.203  33.389 11 CC_DT12DA13:DT7DA8_BB  C 12 ? B 8  ? C 13 ? B 7  ? 
1 B DA 13 1_555 C DT 7  1_555 B DA 14 1_555 C DT 6  1_555 0.119  0.122  3.128 -3.636 -8.322 38.937 1.090  -0.573 3.018 -12.282 
5.366   39.941 12 CC_DA13DA14:DT6DT7_BB  C 13 ? B 7  ? C 14 ? B 6  ? 
1 B DA 14 1_555 C DT 6  1_555 B DA 15 1_555 C DT 5  1_555 0.082  -0.399 3.037 -0.450 -8.748 38.933 0.367  -0.169 3.052 -12.926 
0.665   39.869 13 CC_DA14DA15:DT5DT6_BB  C 14 ? B 6  ? C 15 ? B 5  ? 
1 B DA 15 1_555 C DT 5  1_555 B DT 16 1_555 C DA 4  1_555 0.531  -0.510 3.604 6.346  -0.376 32.733 -0.819 0.255  3.646 -0.660  
-11.130 33.328 14 CC_DA15DT16:DA4DT5_BB  C 15 ? B 5  ? C 16 ? B 4  ? 
1 B DT 16 1_555 C DA 4  1_555 B DG 17 1_555 C DC 3  1_555 -0.099 0.335  3.332 2.565  11.996 34.093 -1.214 0.534  3.247 19.687  
-4.210  36.171 15 CC_DT16DG17:DC3DA4_BB  C 16 ? B 4  ? C 17 ? B 3  ? 
1 B DG 17 1_555 C DC 3  1_555 B DC 18 1_555 C DG 2  1_555 -0.360 0.873  3.419 0.189  5.186  40.179 0.646  0.543  3.499 7.510   
-0.274  40.499 16 CC_DG17DC18:DG2DC3_BB  C 17 ? B 3  ? C 18 ? B 2  ? 
# 
_pdbx_audit_support.funding_organization   'Japan Society for the Promotion of Science (JSPS)' 
_pdbx_audit_support.country                Japan 
_pdbx_audit_support.grant_number           21H02408 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1BF5 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8YYV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . MET A 1 161 ? 65.043  97.384  115.407 1.00 345.81 ? 135 MET A N     1 
ATOM   2    C CA    . MET A 1 161 ? 64.317  98.668  115.610 1.00 348.00 ? 135 MET A CA    1 
ATOM   3    C C     . MET A 1 161 ? 63.700  98.661  117.011 1.00 278.08 ? 135 MET A C     1 
ATOM   4    O O     . MET A 1 161 ? 64.412  98.428  117.986 1.00 246.27 ? 135 MET A O     1 
ATOM   5    C CB    . MET A 1 161 ? 63.256  98.873  114.519 1.00 389.89 ? 135 MET A CB    1 
ATOM   6    C CG    . MET A 1 161 ? 63.786  98.862  113.095 1.00 410.76 ? 135 MET A CG    1 
ATOM   7    S SD    . MET A 1 161 ? 62.473  98.605  111.884 1.00 445.10 ? 135 MET A SD    1 
ATOM   8    C CE    . MET A 1 161 ? 61.990  96.912  112.251 1.00 432.86 ? 135 MET A CE    1 
ATOM   9    N N     . LEU A 1 162 ? 62.379  98.897  117.100 1.00 245.54 ? 136 LEU A N     1 
ATOM   10   C CA    . LEU A 1 162 ? 61.644  98.872  118.356 1.00 226.42 ? 136 LEU A CA    1 
ATOM   11   C C     . LEU A 1 162 ? 61.099  97.464  118.597 1.00 186.44 ? 136 LEU A C     1 
ATOM   12   O O     . LEU A 1 162 ? 59.954  97.305  119.018 1.00 174.48 ? 136 LEU A O     1 
ATOM   13   C CB    . LEU A 1 162 ? 60.506  99.898  118.347 1.00 280.83 ? 136 LEU A CB    1 
ATOM   14   C CG    . LEU A 1 162 ? 60.853  101.337 117.943 1.00 316.55 ? 136 LEU A CG    1 
ATOM   15   C CD1   . LEU A 1 162 ? 60.562  101.603 116.470 1.00 324.72 ? 136 LEU A CD1   1 
ATOM   16   C CD2   . LEU A 1 162 ? 60.116  102.348 118.812 1.00 320.67 ? 136 LEU A CD2   1 
ATOM   17   N N     . ASP A 1 163 ? 61.930  96.447  118.331 1.00 203.25 ? 137 ASP A N     1 
ATOM   18   C CA    . ASP A 1 163 ? 61.538  95.053  118.459 1.00 217.67 ? 137 ASP A CA    1 
ATOM   19   C C     . ASP A 1 163 ? 61.589  94.682  119.937 1.00 182.08 ? 137 ASP A C     1 
ATOM   20   O O     . ASP A 1 163 ? 60.615  94.169  120.489 1.00 174.99 ? 137 ASP A O     1 
ATOM   21   C CB    . ASP A 1 163 ? 62.432  94.160  117.606 1.00 245.38 ? 137 ASP A CB    1 
ATOM   22   C CG    . ASP A 1 163 ? 62.072  92.680  117.552 1.00 262.28 ? 137 ASP A CG    1 
ATOM   23   O OD1   . ASP A 1 163 ? 60.986  92.310  118.062 1.00 252.90 ? 137 ASP A OD1   1 
ATOM   24   O OD2   . ASP A 1 163 ? 62.890  91.904  117.004 1.00 233.01 ? 137 ASP A OD2   1 
ATOM   25   N N     . LYS A 1 164 ? 62.761  94.931  120.536 1.00 168.99 ? 138 LYS A N     1 
ATOM   26   C CA    . LYS A 1 164 ? 62.983  94.759  121.962 1.00 161.99 ? 138 LYS A CA    1 
ATOM   27   C C     . LYS A 1 164 ? 62.653  96.075  122.655 1.00 123.13 ? 138 LYS A C     1 
ATOM   28   O O     . LYS A 1 164 ? 61.856  96.112  123.584 1.00 124.30 ? 138 LYS A O     1 
ATOM   29   C CB    . LYS A 1 164 ? 64.431  94.327  122.227 1.00 151.06 ? 138 LYS A CB    1 
ATOM   30   C CG    . LYS A 1 164 ? 64.770  92.899  121.810 1.00 165.17 ? 138 LYS A CG    1 
ATOM   31   C CD    . LYS A 1 164 ? 63.871  91.813  122.399 1.00 166.70 ? 138 LYS A CD    1 
ATOM   32   C CE    . LYS A 1 164 ? 64.548  90.458  122.486 1.00 201.25 ? 138 LYS A CE    1 
ATOM   33   N NZ    . LYS A 1 164 ? 65.307  90.009  121.310 1.00 190.37 ? 138 LYS A NZ    1 
ATOM   34   N N     . GLN A 1 165 ? 63.244  97.151  122.136 1.00 106.28 ? 139 GLN A N     1 
ATOM   35   C CA    . GLN A 1 165 ? 63.304  98.440  122.807 1.00 109.78 ? 139 GLN A CA    1 
ATOM   36   C C     . GLN A 1 165 ? 61.905  98.797  123.281 1.00 146.85 ? 139 GLN A C     1 
ATOM   37   O O     . GLN A 1 165 ? 61.736  99.341  124.366 1.00 190.49 ? 139 GLN A O     1 
ATOM   38   C CB    . GLN A 1 165 ? 63.856  99.571  121.926 1.00 108.75 ? 139 GLN A CB    1 
ATOM   39   C CG    . GLN A 1 165 ? 65.372  99.535  121.657 1.00 160.98 ? 139 GLN A CG    1 
ATOM   40   C CD    . GLN A 1 165 ? 66.007  98.257  121.098 1.00 165.80 ? 139 GLN A CD    1 
ATOM   41   O OE1   . GLN A 1 165 ? 65.372  97.219  120.870 1.00 166.30 ? 139 GLN A OE1   1 
ATOM   42   N NE2   . GLN A 1 165 ? 67.315  98.317  120.873 1.00 142.12 ? 139 GLN A NE2   1 
ATOM   43   N N     . LYS A 1 166 ? 60.911  98.454  122.465 1.00 147.10 ? 140 LYS A N     1 
ATOM   44   C CA    . LYS A 1 166 ? 59.537  98.694  122.840 1.00 146.58 ? 140 LYS A CA    1 
ATOM   45   C C     . LYS A 1 166 ? 59.228  97.788  124.033 1.00 151.56 ? 140 LYS A C     1 
ATOM   46   O O     . LYS A 1 166 ? 58.961  98.295  125.124 1.00 154.38 ? 140 LYS A O     1 
ATOM   47   C CB    . LYS A 1 166 ? 58.667  98.491  121.598 1.00 181.41 ? 140 LYS A CB    1 
ATOM   48   C CG    . LYS A 1 166 ? 57.554  99.513  121.417 1.00 210.47 ? 140 LYS A CG    1 
ATOM   49   C CD    . LYS A 1 166 ? 56.408  99.015  120.538 1.00 229.81 ? 140 LYS A CD    1 
ATOM   50   C CE    . LYS A 1 166 ? 55.553  97.978  121.221 1.00 224.78 ? 140 LYS A CE    1 
ATOM   51   N NZ    . LYS A 1 166 ? 54.293  97.702  120.528 1.00 207.70 ? 140 LYS A NZ    1 
ATOM   52   N N     . GLU A 1 167 ? 59.319  96.460  123.845 1.00 117.47 ? 141 GLU A N     1 
ATOM   53   C CA    . GLU A 1 167 ? 59.138  95.538  124.954 1.00 129.77 ? 141 GLU A CA    1 
ATOM   54   C C     . GLU A 1 167 ? 59.822  96.131  126.196 1.00 145.98 ? 141 GLU A C     1 
ATOM   55   O O     . GLU A 1 167 ? 59.139  96.631  127.092 1.00 118.37 ? 141 GLU A O     1 
ATOM   56   C CB    . GLU A 1 167 ? 59.591  94.125  124.570 1.00 127.20 ? 141 GLU A CB    1 
ATOM   57   C CG    . GLU A 1 167 ? 59.780  93.179  125.760 1.00 188.79 ? 141 GLU A CG    1 
ATOM   58   C CD    . GLU A 1 167 ? 58.593  92.840  126.668 1.00 225.14 ? 141 GLU A CD    1 
ATOM   59   O OE1   . GLU A 1 167 ? 58.158  93.712  127.454 1.00 224.84 ? 141 GLU A OE1   1 
ATOM   60   O OE2   . GLU A 1 167 ? 58.111  91.682  126.620 1.00 221.30 ? 141 GLU A OE2   1 
ATOM   61   N N     . LEU A 1 168 ? 61.170  96.119  126.220 1.00 148.00 ? 142 LEU A N     1 
ATOM   62   C CA    . LEU A 1 168 ? 61.938  96.629  127.347 1.00 108.32 ? 142 LEU A CA    1 
ATOM   63   C C     . LEU A 1 168 ? 61.236  97.871  127.858 1.00 109.59 ? 142 LEU A C     1 
ATOM   64   O O     . LEU A 1 168 ? 60.690  97.856  128.962 1.00 120.48 ? 142 LEU A O     1 
ATOM   65   C CB    . LEU A 1 168 ? 63.401  96.964  127.059 1.00 106.70 ? 142 LEU A CB    1 
ATOM   66   C CG    . LEU A 1 168 ? 64.246  97.179  128.321 1.00 132.63 ? 142 LEU A CG    1 
ATOM   67   C CD1   . LEU A 1 168 ? 64.057  96.010  129.284 1.00 137.91 ? 142 LEU A CD1   1 
ATOM   68   C CD2   . LEU A 1 168 ? 65.714  97.317  128.065 1.00 155.05 ? 142 LEU A CD2   1 
ATOM   69   N N     . ASP A 1 169 ? 61.225  98.912  127.018 1.00 93.81  ? 143 ASP A N     1 
ATOM   70   C CA    . ASP A 1 169 ? 60.660  100.179 127.432 1.00 97.83  ? 143 ASP A CA    1 
ATOM   71   C C     . ASP A 1 169 ? 59.391  99.884  128.216 1.00 114.73 ? 143 ASP A C     1 
ATOM   72   O O     . ASP A 1 169 ? 59.323  100.181 129.407 1.00 125.06 ? 143 ASP A O     1 
ATOM   73   C CB    . ASP A 1 169 ? 60.461  101.140 126.277 1.00 114.03 ? 143 ASP A CB    1 
ATOM   74   C CG    . ASP A 1 169 ? 60.699  102.603 126.637 1.00 163.59 ? 143 ASP A CG    1 
ATOM   75   O OD1   . ASP A 1 169 ? 59.900  103.147 127.440 1.00 176.75 ? 143 ASP A OD1   1 
ATOM   76   O OD2   . ASP A 1 169 ? 61.704  103.179 126.137 1.00 168.29 ? 143 ASP A OD2   1 
ATOM   77   N N     . SER A 1 170 ? 58.435  99.215  127.567 1.00 114.39 ? 144 SER A N     1 
ATOM   78   C CA    . SER A 1 170 ? 57.183  98.893  128.223 1.00 140.98 ? 144 SER A CA    1 
ATOM   79   C C     . SER A 1 170 ? 57.426  98.583  129.704 1.00 142.86 ? 144 SER A C     1 
ATOM   80   O O     . SER A 1 170 ? 56.776  99.156  130.586 1.00 143.37 ? 144 SER A O     1 
ATOM   81   C CB    . SER A 1 170 ? 56.489  97.737  127.540 1.00 144.53 ? 144 SER A CB    1 
ATOM   82   O OG    . SER A 1 170 ? 56.579  97.822  126.129 1.00 130.83 ? 144 SER A OG    1 
ATOM   83   N N     . LYS A 1 171 ? 58.364  97.662  129.962 1.00 100.15 ? 145 LYS A N     1 
ATOM   84   C CA    . LYS A 1 171 ? 58.496  97.079  131.280 1.00 92.32  ? 145 LYS A CA    1 
ATOM   85   C C     . LYS A 1 171 ? 58.907  98.182  132.249 1.00 112.48 ? 145 LYS A C     1 
ATOM   86   O O     . LYS A 1 171 ? 58.444  98.206  133.381 1.00 143.06 ? 145 LYS A O     1 
ATOM   87   C CB    . LYS A 1 171 ? 59.498  95.928  131.243 1.00 93.38  ? 145 LYS A CB    1 
ATOM   88   C CG    . LYS A 1 171 ? 59.231  94.908  130.151 1.00 129.98 ? 145 LYS A CG    1 
ATOM   89   C CD    . LYS A 1 171 ? 60.258  93.785  130.021 1.00 140.22 ? 145 LYS A CD    1 
ATOM   90   C CE    . LYS A 1 171 ? 60.090  92.679  131.021 1.00 140.21 ? 145 LYS A CE    1 
ATOM   91   N NZ    . LYS A 1 171 ? 60.963  91.564  130.652 1.00 145.19 ? 145 LYS A NZ    1 
ATOM   92   N N     . VAL A 1 172 ? 59.768  99.098  131.805 1.00 89.98  ? 146 VAL A N     1 
ATOM   93   C CA    . VAL A 1 172 ? 60.309  100.113 132.686 1.00 74.61  ? 146 VAL A CA    1 
ATOM   94   C C     . VAL A 1 172 ? 59.210  101.088 133.100 1.00 79.91  ? 146 VAL A C     1 
ATOM   95   O O     . VAL A 1 172 ? 59.183  101.531 134.237 1.00 122.59 ? 146 VAL A O     1 
ATOM   96   C CB    . VAL A 1 172 ? 61.470  100.819 131.966 1.00 82.10  ? 146 VAL A CB    1 
ATOM   97   C CG1   . VAL A 1 172 ? 61.885  102.141 132.621 1.00 76.89  ? 146 VAL A CG1   1 
ATOM   98   C CG2   . VAL A 1 172 ? 62.659  99.885  131.832 1.00 69.95  ? 146 VAL A CG2   1 
ATOM   99   N N     . ARG A 1 173 ? 58.280  101.412 132.212 1.00 89.30  ? 147 ARG A N     1 
ATOM   100  C CA    . ARG A 1 173 ? 57.091  102.151 132.615 1.00 103.95 ? 147 ARG A CA    1 
ATOM   101  C C     . ARG A 1 173 ? 56.412  101.399 133.759 1.00 86.43  ? 147 ARG A C     1 
ATOM   102  O O     . ARG A 1 173 ? 56.225  101.959 134.830 1.00 72.61  ? 147 ARG A O     1 
ATOM   103  C CB    . ARG A 1 173 ? 56.083  102.301 131.460 1.00 169.61 ? 147 ARG A CB    1 
ATOM   104  C CG    . ARG A 1 173 ? 56.619  102.739 130.099 1.00 226.00 ? 147 ARG A CG    1 
ATOM   105  C CD    . ARG A 1 173 ? 57.102  104.186 130.046 1.00 261.89 ? 147 ARG A CD    1 
ATOM   106  N NE    . ARG A 1 173 ? 55.971  105.122 130.049 1.00 264.42 ? 147 ARG A NE    1 
ATOM   107  C CZ    . ARG A 1 173 ? 55.882  106.257 130.737 1.00 231.32 ? 147 ARG A CZ    1 
ATOM   108  N NH1   . ARG A 1 173 ? 56.924  106.721 131.410 1.00 206.95 ? 147 ARG A NH1   1 
ATOM   109  N NH2   . ARG A 1 173 ? 54.752  106.945 130.717 1.00 225.73 ? 147 ARG A NH2   1 
ATOM   110  N N     . ASN A 1 174 ? 56.111  100.109 133.524 1.00 91.59  ? 148 ASN A N     1 
ATOM   111  C CA    . ASN A 1 174 ? 55.512  99.168  134.480 1.00 116.62 ? 148 ASN A CA    1 
ATOM   112  C C     . ASN A 1 174 ? 56.050  99.301  135.913 1.00 98.50  ? 148 ASN A C     1 
ATOM   113  O O     . ASN A 1 174 ? 55.341  99.169  136.909 1.00 108.73 ? 148 ASN A O     1 
ATOM   114  C CB    . ASN A 1 174 ? 55.791  97.729  134.040 1.00 115.47 ? 148 ASN A CB    1 
ATOM   115  C CG    . ASN A 1 174 ? 54.859  96.685  134.609 1.00 116.22 ? 148 ASN A CG    1 
ATOM   116  O OD1   . ASN A 1 174 ? 53.908  96.973  135.354 1.00 98.82  ? 148 ASN A OD1   1 
ATOM   117  N ND2   . ASN A 1 174 ? 55.114  95.444  134.219 1.00 128.17 ? 148 ASN A ND2   1 
ATOM   118  N N     . VAL A 1 175 ? 57.346  99.501  136.007 1.00 88.04  ? 149 VAL A N     1 
ATOM   119  C CA    . VAL A 1 175 ? 57.990  99.655  137.283 1.00 80.61  ? 149 VAL A CA    1 
ATOM   120  C C     . VAL A 1 175 ? 57.612  100.997 137.870 1.00 78.46  ? 149 VAL A C     1 
ATOM   121  O O     . VAL A 1 175 ? 57.116  101.093 138.986 1.00 82.90  ? 149 VAL A O     1 
ATOM   122  C CB    . VAL A 1 175 ? 59.486  99.587  136.999 1.00 77.68  ? 149 VAL A CB    1 
ATOM   123  C CG1   . VAL A 1 175 ? 60.243  99.680  138.305 1.00 81.85  ? 149 VAL A CG1   1 
ATOM   124  C CG2   . VAL A 1 175 ? 59.821  98.309  136.231 1.00 78.57  ? 149 VAL A CG2   1 
ATOM   125  N N     . LYS A 1 176 ? 57.841  102.022 137.061 1.00 90.49  ? 150 LYS A N     1 
ATOM   126  C CA    . LYS A 1 176 ? 57.583  103.396 137.452 1.00 100.74 ? 150 LYS A CA    1 
ATOM   127  C C     . LYS A 1 176 ? 56.128  103.563 137.896 1.00 107.32 ? 150 LYS A C     1 
ATOM   128  O O     . LYS A 1 176 ? 55.839  104.349 138.798 1.00 64.77  ? 150 LYS A O     1 
ATOM   129  C CB    . LYS A 1 176 ? 57.925  104.338 136.290 1.00 76.32  ? 150 LYS A CB    1 
ATOM   130  C CG    . LYS A 1 176 ? 58.157  105.699 136.830 1.00 89.44  ? 150 LYS A CG    1 
ATOM   131  C CD    . LYS A 1 176 ? 59.025  106.507 135.881 1.00 153.63 ? 150 LYS A CD    1 
ATOM   132  C CE    . LYS A 1 176 ? 58.242  107.076 134.718 1.00 205.10 ? 150 LYS A CE    1 
ATOM   133  N NZ    . LYS A 1 176 ? 57.440  108.267 135.039 1.00 208.91 ? 150 LYS A NZ    1 
ATOM   134  N N     . ASP A 1 177 ? 55.221  102.859 137.196 1.00 130.21 ? 151 ASP A N     1 
ATOM   135  C CA    . ASP A 1 177 ? 53.795  102.946 137.459 1.00 123.77 ? 151 ASP A CA    1 
ATOM   136  C C     . ASP A 1 177 ? 53.576  102.300 138.810 1.00 104.57 ? 151 ASP A C     1 
ATOM   137  O O     . ASP A 1 177 ? 53.078  102.920 139.752 1.00 106.66 ? 151 ASP A O     1 
ATOM   138  C CB    . ASP A 1 177 ? 52.970  102.318 136.347 1.00 130.61 ? 151 ASP A CB    1 
ATOM   139  C CG    . ASP A 1 177 ? 53.087  103.024 135.001 1.00 186.33 ? 151 ASP A CG    1 
ATOM   140  O OD1   . ASP A 1 177 ? 52.980  104.275 134.971 1.00 191.43 ? 151 ASP A OD1   1 
ATOM   141  O OD2   . ASP A 1 177 ? 53.288  102.318 133.990 1.00 222.84 ? 151 ASP A OD2   1 
ATOM   142  N N     . LYS A 1 178 ? 54.050  101.072 138.915 1.00 82.95  ? 152 LYS A N     1 
ATOM   143  C CA    . LYS A 1 178 ? 53.846  100.377 140.165 1.00 102.13 ? 152 LYS A CA    1 
ATOM   144  C C     . LYS A 1 178 ? 54.330  101.196 141.370 1.00 108.56 ? 152 LYS A C     1 
ATOM   145  O O     . LYS A 1 178 ? 53.663  101.198 142.398 1.00 108.63 ? 152 LYS A O     1 
ATOM   146  C CB    . LYS A 1 178 ? 54.336  98.943  139.988 1.00 90.22  ? 152 LYS A CB    1 
ATOM   147  C CG    . LYS A 1 178 ? 53.147  98.073  139.602 1.00 113.98 ? 152 LYS A CG    1 
ATOM   148  C CD    . LYS A 1 178 ? 53.367  96.565  139.627 1.00 140.75 ? 152 LYS A CD    1 
ATOM   149  C CE    . LYS A 1 178 ? 53.675  95.970  138.295 1.00 123.91 ? 152 LYS A CE    1 
ATOM   150  N NZ    . LYS A 1 178 ? 53.013  94.664  138.232 1.00 139.22 ? 152 LYS A NZ    1 
ATOM   151  N N     . VAL A 1 179 ? 55.418  101.955 141.230 1.00 96.28  ? 153 VAL A N     1 
ATOM   152  C CA    . VAL A 1 179 ? 56.006  102.639 142.366 1.00 87.52  ? 153 VAL A CA    1 
ATOM   153  C C     . VAL A 1 179 ? 55.131  103.792 142.852 1.00 92.05  ? 153 VAL A C     1 
ATOM   154  O O     . VAL A 1 179 ? 54.872  103.901 144.051 1.00 82.18  ? 153 VAL A O     1 
ATOM   155  C CB    . VAL A 1 179 ? 57.395  103.111 141.935 1.00 88.32  ? 153 VAL A CB    1 
ATOM   156  C CG1   . VAL A 1 179 ? 57.952  104.253 142.758 1.00 105.33 ? 153 VAL A CG1   1 
ATOM   157  C CG2   . VAL A 1 179 ? 58.353  101.965 141.994 1.00 96.79  ? 153 VAL A CG2   1 
ATOM   158  N N     . MET A 1 180 ? 54.638  104.633 141.940 1.00 110.23 ? 154 MET A N     1 
ATOM   159  C CA    . MET A 1 180 ? 53.600  105.600 142.294 1.00 139.75 ? 154 MET A CA    1 
ATOM   160  C C     . MET A 1 180 ? 52.473  104.903 143.064 1.00 127.91 ? 154 MET A C     1 
ATOM   161  O O     . MET A 1 180 ? 52.163  105.232 144.222 1.00 72.73  ? 154 MET A O     1 
ATOM   162  C CB    . MET A 1 180 ? 52.995  106.259 141.042 1.00 174.78 ? 154 MET A CB    1 
ATOM   163  C CG    . MET A 1 180 ? 53.979  107.100 140.255 1.00 192.82 ? 154 MET A CG    1 
ATOM   164  S SD    . MET A 1 180 ? 54.863  108.237 141.343 1.00 184.62 ? 154 MET A SD    1 
ATOM   165  C CE    . MET A 1 180 ? 56.510  108.238 140.613 1.00 157.42 ? 154 MET A CE    1 
ATOM   166  N N     . CYS A 1 181 ? 51.900  103.891 142.402 1.00 106.69 ? 155 CYS A N     1 
ATOM   167  C CA    . CYS A 1 181 ? 50.760  103.170 142.922 1.00 98.77  ? 155 CYS A CA    1 
ATOM   168  C C     . CYS A 1 181 ? 50.954  102.670 144.352 1.00 114.57 ? 155 CYS A C     1 
ATOM   169  O O     . CYS A 1 181 ? 50.073  102.828 145.190 1.00 114.36 ? 155 CYS A O     1 
ATOM   170  C CB    . CYS A 1 181 ? 50.367  102.111 141.924 1.00 93.96  ? 155 CYS A CB    1 
ATOM   171  S SG    . CYS A 1 181 ? 49.171  102.836 140.770 1.00 155.82 ? 155 CYS A SG    1 
ATOM   172  N N     . ILE A 1 182 ? 52.107  102.078 144.645 1.00 120.70 ? 156 ILE A N     1 
ATOM   173  C CA    . ILE A 1 182 ? 52.448  101.782 146.025 1.00 94.25  ? 156 ILE A CA    1 
ATOM   174  C C     . ILE A 1 182 ? 52.170  103.025 146.846 1.00 94.33  ? 156 ILE A C     1 
ATOM   175  O O     . ILE A 1 182 ? 51.579  102.914 147.926 1.00 63.31  ? 156 ILE A O     1 
ATOM   176  C CB    . ILE A 1 182 ? 53.927  101.394 146.133 1.00 97.41  ? 156 ILE A CB    1 
ATOM   177  C CG1   . ILE A 1 182 ? 54.253  100.219 145.200 1.00 105.78 ? 156 ILE A CG1   1 
ATOM   178  C CG2   . ILE A 1 182 ? 54.331  101.110 147.590 1.00 94.76  ? 156 ILE A CG2   1 
ATOM   179  C CD1   . ILE A 1 182 ? 53.329  99.026  145.376 1.00 103.80 ? 156 ILE A CD1   1 
ATOM   180  N N     . GLU A 1 183 ? 52.588  104.169 146.254 1.00 92.77  ? 157 GLU A N     1 
ATOM   181  C CA    . GLU A 1 183 ? 52.828  105.422 146.951 1.00 102.66 ? 157 GLU A CA    1 
ATOM   182  C C     . GLU A 1 183 ? 51.508  106.053 147.386 1.00 113.20 ? 157 GLU A C     1 
ATOM   183  O O     . GLU A 1 183 ? 51.454  106.674 148.453 1.00 92.84  ? 157 GLU A O     1 
ATOM   184  C CB    . GLU A 1 183 ? 53.721  106.368 146.139 1.00 97.00  ? 157 GLU A CB    1 
ATOM   185  C CG    . GLU A 1 183 ? 54.331  107.515 146.956 1.00 138.63 ? 157 GLU A CG    1 
ATOM   186  C CD    . GLU A 1 183 ? 55.421  107.253 148.012 1.00 183.43 ? 157 GLU A CD    1 
ATOM   187  O OE1   . GLU A 1 183 ? 56.497  106.695 147.661 1.00 170.24 ? 157 GLU A OE1   1 
ATOM   188  O OE2   . GLU A 1 183 ? 55.224  107.656 149.195 1.00 158.66 ? 157 GLU A OE2   1 
ATOM   189  N N     . HIS A 1 184 ? 50.460  105.908 146.554 1.00 137.60 ? 158 HIS A N     1 
ATOM   190  C CA    . HIS A 1 184 ? 49.110  106.260 146.991 1.00 155.85 ? 158 HIS A CA    1 
ATOM   191  C C     . HIS A 1 184 ? 48.847  105.319 148.167 1.00 119.69 ? 158 HIS A C     1 
ATOM   192  O O     . HIS A 1 184 ? 49.030  105.670 149.333 1.00 85.47  ? 158 HIS A O     1 
ATOM   193  C CB    . HIS A 1 184 ? 48.116  106.392 145.807 1.00 127.98 ? 158 HIS A CB    1 
ATOM   194  C CG    . HIS A 1 184 ? 48.647  107.390 144.823 1.00 153.83 ? 158 HIS A CG    1 
ATOM   195  N ND1   . HIS A 1 184 ? 48.756  108.733 145.128 1.00 171.71 ? 158 HIS A ND1   1 
ATOM   196  C CD2   . HIS A 1 184 ? 49.264  107.242 143.631 1.00 177.36 ? 158 HIS A CD2   1 
ATOM   197  C CE1   . HIS A 1 184 ? 49.358  109.371 144.123 1.00 182.28 ? 158 HIS A CE1   1 
ATOM   198  N NE2   . HIS A 1 184 ? 49.683  108.484 143.203 1.00 153.40 ? 158 HIS A NE2   1 
ATOM   199  N N     . GLU A 1 185 ? 48.624  104.059 147.837 1.00 114.97 ? 159 GLU A N     1 
ATOM   200  C CA    . GLU A 1 185 ? 48.361  103.077 148.855 1.00 96.72  ? 159 GLU A CA    1 
ATOM   201  C C     . GLU A 1 185 ? 49.100  103.440 150.143 1.00 94.67  ? 159 GLU A C     1 
ATOM   202  O O     . GLU A 1 185 ? 48.548  103.209 151.209 1.00 130.54 ? 159 GLU A O     1 
ATOM   203  C CB    . GLU A 1 185 ? 48.708  101.677 148.350 1.00 118.68 ? 159 GLU A CB    1 
ATOM   204  C CG    . GLU A 1 185 ? 47.991  101.248 147.066 1.00 150.86 ? 159 GLU A CG    1 
ATOM   205  C CD    . GLU A 1 185 ? 47.591  99.770  146.919 1.00 179.76 ? 159 GLU A CD    1 
ATOM   206  O OE1   . GLU A 1 185 ? 47.683  98.993  147.899 1.00 196.48 ? 159 GLU A OE1   1 
ATOM   207  O OE2   . GLU A 1 185 ? 47.166  99.368  145.810 1.00 157.86 ? 159 GLU A OE2   1 
ATOM   208  N N     . ILE A 1 186 ? 50.330  103.976 150.111 1.00 91.89  ? 160 ILE A N     1 
ATOM   209  C CA    . ILE A 1 186 ? 51.029  104.164 151.382 1.00 111.66 ? 160 ILE A CA    1 
ATOM   210  C C     . ILE A 1 186 ? 50.418  105.321 152.165 1.00 138.63 ? 160 ILE A C     1 
ATOM   211  O O     . ILE A 1 186 ? 50.484  105.338 153.405 1.00 101.86 ? 160 ILE A O     1 
ATOM   212  C CB    . ILE A 1 186 ? 52.540  104.391 151.207 1.00 123.59 ? 160 ILE A CB    1 
ATOM   213  C CG1   . ILE A 1 186 ? 53.323  103.074 151.150 1.00 140.81 ? 160 ILE A CG1   1 
ATOM   214  C CG2   . ILE A 1 186 ? 53.074  105.286 152.328 1.00 128.68 ? 160 ILE A CG2   1 
ATOM   215  C CD1   . ILE A 1 186 ? 53.130  102.179 152.366 1.00 125.88 ? 160 ILE A CD1   1 
ATOM   216  N N     . LYS A 1 187 ? 49.931  106.314 151.396 1.00 159.19 ? 161 LYS A N     1 
ATOM   217  C CA    . LYS A 1 187 ? 49.338  107.537 151.921 1.00 162.45 ? 161 LYS A CA    1 
ATOM   218  C C     . LYS A 1 187 ? 48.032  107.142 152.587 1.00 143.05 ? 161 LYS A C     1 
ATOM   219  O O     . LYS A 1 187 ? 47.870  107.238 153.801 1.00 141.77 ? 161 LYS A O     1 
ATOM   220  C CB    . LYS A 1 187 ? 49.120  108.581 150.812 1.00 150.49 ? 161 LYS A CB    1 
ATOM   221  C CG    . LYS A 1 187 ? 49.009  110.053 151.227 1.00 163.70 ? 161 LYS A CG    1 
ATOM   222  C CD    . LYS A 1 187 ? 49.116  111.009 150.033 1.00 203.40 ? 161 LYS A CD    1 
ATOM   223  C CE    . LYS A 1 187 ? 49.087  112.495 150.341 1.00 199.39 ? 161 LYS A CE    1 
ATOM   224  N NZ    . LYS A 1 187 ? 49.183  113.377 149.163 1.00 149.73 ? 161 LYS A NZ    1 
ATOM   225  N N     . SER A 1 188 ? 47.145  106.598 151.767 1.00 130.34 ? 162 SER A N     1 
ATOM   226  C CA    . SER A 1 188 ? 45.842  106.179 152.232 1.00 144.52 ? 162 SER A CA    1 
ATOM   227  C C     . SER A 1 188 ? 45.956  105.301 153.482 1.00 106.46 ? 162 SER A C     1 
ATOM   228  O O     . SER A 1 188 ? 45.134  105.406 154.385 1.00 98.90  ? 162 SER A O     1 
ATOM   229  C CB    . SER A 1 188 ? 45.110  105.533 151.089 1.00 193.34 ? 162 SER A CB    1 
ATOM   230  O OG    . SER A 1 188 ? 45.103  106.422 149.970 1.00 179.10 ? 162 SER A OG    1 
ATOM   231  N N     . LEU A 1 189 ? 47.008  104.487 153.556 1.00 103.15 ? 163 LEU A N     1 
ATOM   232  C CA    . LEU A 1 189 ? 47.273  103.689 154.739 1.00 114.45 ? 163 LEU A CA    1 
ATOM   233  C C     . LEU A 1 189 ? 47.903  104.575 155.814 1.00 110.81 ? 163 LEU A C     1 
ATOM   234  O O     . LEU A 1 189 ? 47.750  104.325 157.021 1.00 93.05  ? 163 LEU A O     1 
ATOM   235  C CB    . LEU A 1 189 ? 48.189  102.521 154.368 1.00 127.57 ? 163 LEU A CB    1 
ATOM   236  C CG    . LEU A 1 189 ? 48.711  101.655 155.526 1.00 140.52 ? 163 LEU A CG    1 
ATOM   237  C CD1   . LEU A 1 189 ? 47.712  100.673 156.162 1.00 137.08 ? 163 LEU A CD1   1 
ATOM   238  C CD2   . LEU A 1 189 ? 49.909  100.919 154.987 1.00 118.97 ? 163 LEU A CD2   1 
ATOM   239  N N     . GLU A 1 190 ? 48.685  105.565 155.372 1.00 96.51  ? 164 GLU A N     1 
ATOM   240  C CA    . GLU A 1 190 ? 49.219  106.496 156.341 1.00 125.66 ? 164 GLU A CA    1 
ATOM   241  C C     . GLU A 1 190 ? 48.033  107.270 156.918 1.00 154.52 ? 164 GLU A C     1 
ATOM   242  O O     . GLU A 1 190 ? 48.111  107.713 158.058 1.00 160.53 ? 164 GLU A O     1 
ATOM   243  C CB    . GLU A 1 190 ? 50.410  107.319 155.840 1.00 139.78 ? 164 GLU A CB    1 
ATOM   244  C CG    . GLU A 1 190 ? 50.698  108.606 156.639 1.00 194.58 ? 164 GLU A CG    1 
ATOM   245  C CD    . GLU A 1 190 ? 51.129  108.695 158.124 1.00 175.57 ? 164 GLU A CD    1 
ATOM   246  O OE1   . GLU A 1 190 ? 50.313  108.414 159.031 1.00 132.20 ? 164 GLU A OE1   1 
ATOM   247  O OE2   . GLU A 1 190 ? 52.283  109.132 158.403 1.00 144.17 ? 164 GLU A OE2   1 
ATOM   248  N N     . ASP A 1 191 ? 46.920  107.413 156.181 1.00 136.29 ? 165 ASP A N     1 
ATOM   249  C CA    . ASP A 1 191 ? 45.778  108.066 156.796 1.00 140.60 ? 165 ASP A CA    1 
ATOM   250  C C     . ASP A 1 191 ? 45.090  107.116 157.772 1.00 123.89 ? 165 ASP A C     1 
ATOM   251  O O     . ASP A 1 191 ? 44.920  107.444 158.939 1.00 110.61 ? 165 ASP A O     1 
ATOM   252  C CB    . ASP A 1 191 ? 44.771  108.637 155.815 1.00 183.18 ? 165 ASP A CB    1 
ATOM   253  C CG    . ASP A 1 191 ? 43.579  109.321 156.483 1.00 237.49 ? 165 ASP A CG    1 
ATOM   254  O OD1   . ASP A 1 191 ? 43.798  110.357 157.154 1.00 246.67 ? 165 ASP A OD1   1 
ATOM   255  O OD2   . ASP A 1 191 ? 42.441  108.804 156.355 1.00 226.28 ? 165 ASP A OD2   1 
ATOM   256  N N     . LEU A 1 192 ? 44.699  105.935 157.295 1.00 124.59 ? 166 LEU A N     1 
ATOM   257  C CA    . LEU A 1 192 ? 43.685  105.141 157.976 1.00 120.62 ? 166 LEU A CA    1 
ATOM   258  C C     . LEU A 1 192 ? 44.168  104.667 159.344 1.00 110.67 ? 166 LEU A C     1 
ATOM   259  O O     . LEU A 1 192 ? 43.352  104.394 160.212 1.00 96.56  ? 166 LEU A O     1 
ATOM   260  C CB    . LEU A 1 192 ? 43.288  103.965 157.081 1.00 153.52 ? 166 LEU A CB    1 
ATOM   261  C CG    . LEU A 1 192 ? 42.020  103.176 157.444 1.00 147.90 ? 166 LEU A CG    1 
ATOM   262  C CD1   . LEU A 1 192 ? 40.825  104.055 157.836 1.00 165.82 ? 166 LEU A CD1   1 
ATOM   263  C CD2   . LEU A 1 192 ? 41.603  102.256 156.277 1.00 129.63 ? 166 LEU A CD2   1 
ATOM   264  N N     . GLN A 1 193 ? 45.481  104.587 159.571 1.00 104.40 ? 167 GLN A N     1 
ATOM   265  C CA    . GLN A 1 193 ? 45.964  104.268 160.909 1.00 113.91 ? 167 GLN A CA    1 
ATOM   266  C C     . GLN A 1 193 ? 45.920  105.478 161.858 1.00 143.59 ? 167 GLN A C     1 
ATOM   267  O O     . GLN A 1 193 ? 45.873  105.332 163.093 1.00 105.21 ? 167 GLN A O     1 
ATOM   268  C CB    . GLN A 1 193 ? 47.386  103.743 160.776 1.00 120.97 ? 167 GLN A CB    1 
ATOM   269  C CG    . GLN A 1 193 ? 47.939  103.175 162.080 1.00 120.15 ? 167 GLN A CG    1 
ATOM   270  C CD    . GLN A 1 193 ? 49.443  103.295 162.170 1.00 154.55 ? 167 GLN A CD    1 
ATOM   271  O OE1   . GLN A 1 193 ? 50.171  103.042 161.199 1.00 132.76 ? 167 GLN A OE1   1 
ATOM   272  N NE2   . GLN A 1 193 ? 49.915  103.713 163.339 1.00 163.70 ? 167 GLN A NE2   1 
ATOM   273  N N     . ASP A 1 194 ? 45.981  106.681 161.267 1.00 168.48 ? 168 ASP A N     1 
ATOM   274  C CA    . ASP A 1 194 ? 45.775  107.925 161.995 1.00 179.46 ? 168 ASP A CA    1 
ATOM   275  C C     . ASP A 1 194 ? 44.315  107.969 162.443 1.00 162.36 ? 168 ASP A C     1 
ATOM   276  O O     . ASP A 1 194 ? 44.016  107.870 163.634 1.00 102.89 ? 168 ASP A O     1 
ATOM   277  C CB    . ASP A 1 194 ? 46.141  109.153 161.164 1.00 175.31 ? 168 ASP A CB    1 
ATOM   278  C CG    . ASP A 1 194 ? 47.441  109.072 160.371 1.00 154.84 ? 168 ASP A CG    1 
ATOM   279  O OD1   . ASP A 1 194 ? 47.757  107.962 159.915 1.00 110.24 ? 168 ASP A OD1   1 
ATOM   280  O OD2   . ASP A 1 194 ? 48.098  110.127 160.171 1.00 150.05 ? 168 ASP A OD2   1 
ATOM   281  N N     . GLU A 1 195 ? 43.421  108.073 161.449 1.00 178.35 ? 169 GLU A N     1 
ATOM   282  C CA    . GLU A 1 195 ? 41.985  108.088 161.674 1.00 180.55 ? 169 GLU A CA    1 
ATOM   283  C C     . GLU A 1 195 ? 41.676  107.113 162.811 1.00 169.06 ? 169 GLU A C     1 
ATOM   284  O O     . GLU A 1 195 ? 41.091  107.503 163.819 1.00 167.72 ? 169 GLU A O     1 
ATOM   285  C CB    . GLU A 1 195 ? 41.258  107.816 160.349 1.00 175.12 ? 169 GLU A CB    1 
ATOM   286  C CG    . GLU A 1 195 ? 39.733  107.720 160.449 1.00 164.14 ? 169 GLU A CG    1 
ATOM   287  C CD    . GLU A 1 195 ? 38.971  109.003 160.748 1.00 152.05 ? 169 GLU A CD    1 
ATOM   288  O OE1   . GLU A 1 195 ? 39.593  110.097 160.702 1.00 131.37 ? 169 GLU A OE1   1 
ATOM   289  O OE2   . GLU A 1 195 ? 37.746  108.897 161.026 1.00 135.43 ? 169 GLU A OE2   1 
ATOM   290  N N     . TYR A 1 196 ? 42.086  105.847 162.659 1.00 151.11 ? 170 TYR A N     1 
ATOM   291  C CA    . TYR A 1 196 ? 41.910  104.898 163.740 1.00 131.35 ? 170 TYR A CA    1 
ATOM   292  C C     . TYR A 1 196 ? 42.508  105.566 164.969 1.00 123.77 ? 170 TYR A C     1 
ATOM   293  O O     . TYR A 1 196 ? 41.786  105.736 165.957 1.00 85.55  ? 170 TYR A O     1 
ATOM   294  C CB    . TYR A 1 196 ? 42.526  103.545 163.398 1.00 136.89 ? 170 TYR A CB    1 
ATOM   295  C CG    . TYR A 1 196 ? 42.348  102.396 164.391 1.00 181.72 ? 170 TYR A CG    1 
ATOM   296  C CD1   . TYR A 1 196 ? 41.088  101.836 164.606 1.00 174.29 ? 170 TYR A CD1   1 
ATOM   297  C CD2   . TYR A 1 196 ? 43.451  101.792 165.027 1.00 170.98 ? 170 TYR A CD2   1 
ATOM   298  C CE1   . TYR A 1 196 ? 40.920  100.755 165.461 1.00 178.93 ? 170 TYR A CE1   1 
ATOM   299  C CE2   . TYR A 1 196 ? 43.304  100.699 165.869 1.00 134.85 ? 170 TYR A CE2   1 
ATOM   300  C CZ    . TYR A 1 196 ? 42.027  100.191 166.085 1.00 199.81 ? 170 TYR A CZ    1 
ATOM   301  O OH    . TYR A 1 196 ? 41.832  99.127  166.917 1.00 247.06 ? 170 TYR A OH    1 
ATOM   302  N N     . ASP A 1 197 ? 43.790  105.972 164.872 1.00 105.87 ? 171 ASP A N     1 
ATOM   303  C CA    . ASP A 1 197 ? 44.465  106.552 166.019 1.00 160.15 ? 171 ASP A CA    1 
ATOM   304  C C     . ASP A 1 197 ? 43.557  107.553 166.732 1.00 188.62 ? 171 ASP A C     1 
ATOM   305  O O     . ASP A 1 197 ? 43.422  107.491 167.954 1.00 182.18 ? 171 ASP A O     1 
ATOM   306  C CB    . ASP A 1 197 ? 45.814  107.172 165.696 1.00 209.05 ? 171 ASP A CB    1 
ATOM   307  C CG    . ASP A 1 197 ? 46.446  107.957 166.844 1.00 253.26 ? 171 ASP A CG    1 
ATOM   308  O OD1   . ASP A 1 197 ? 46.490  107.424 167.988 1.00 202.17 ? 171 ASP A OD1   1 
ATOM   309  O OD2   . ASP A 1 197 ? 46.898  109.099 166.590 1.00 265.49 ? 171 ASP A OD2   1 
ATOM   310  N N     . PHE A 1 198 ? 42.940  108.467 165.968 1.00 212.15 ? 172 PHE A N     1 
ATOM   311  C CA    . PHE A 1 198 ? 42.087  109.503 166.536 1.00 211.54 ? 172 PHE A CA    1 
ATOM   312  C C     . PHE A 1 198 ? 40.869  108.878 167.206 1.00 196.96 ? 172 PHE A C     1 
ATOM   313  O O     . PHE A 1 198 ? 40.580  109.174 168.361 1.00 221.45 ? 172 PHE A O     1 
ATOM   314  C CB    . PHE A 1 198 ? 41.575  110.537 165.526 1.00 204.09 ? 172 PHE A CB    1 
ATOM   315  C CG    . PHE A 1 198 ? 40.184  111.080 165.846 1.00 238.32 ? 172 PHE A CG    1 
ATOM   316  C CD1   . PHE A 1 198 ? 39.883  111.639 167.086 1.00 233.60 ? 172 PHE A CD1   1 
ATOM   317  C CD2   . PHE A 1 198 ? 39.151  110.979 164.916 1.00 268.89 ? 172 PHE A CD2   1 
ATOM   318  C CE1   . PHE A 1 198 ? 38.609  112.109 167.368 1.00 245.16 ? 172 PHE A CE1   1 
ATOM   319  C CE2   . PHE A 1 198 ? 37.877  111.450 165.204 1.00 240.12 ? 172 PHE A CE2   1 
ATOM   320  C CZ    . PHE A 1 198 ? 37.608  112.012 166.428 1.00 246.27 ? 172 PHE A CZ    1 
ATOM   321  N N     . LYS A 1 199 ? 40.165  108.005 166.483 1.00 157.84 ? 173 LYS A N     1 
ATOM   322  C CA    . LYS A 1 199 ? 38.898  107.506 166.971 1.00 132.27 ? 173 LYS A CA    1 
ATOM   323  C C     . LYS A 1 199 ? 39.133  106.549 168.142 1.00 184.56 ? 173 LYS A C     1 
ATOM   324  O O     . LYS A 1 199 ? 38.366  106.566 169.105 1.00 197.34 ? 173 LYS A O     1 
ATOM   325  C CB    . LYS A 1 199 ? 38.108  106.881 165.822 1.00 123.16 ? 173 LYS A CB    1 
ATOM   326  C CG    . LYS A 1 199 ? 36.619  106.837 166.094 1.00 120.69 ? 173 LYS A CG    1 
ATOM   327  C CD    . LYS A 1 199 ? 36.087  108.185 166.588 1.00 122.41 ? 173 LYS A CD    1 
ATOM   328  C CE    . LYS A 1 199 ? 34.569  108.430 166.507 1.00 145.18 ? 173 LYS A CE    1 
ATOM   329  N NZ    . LYS A 1 199 ? 33.615  107.633 167.309 1.00 137.77 ? 173 LYS A NZ    1 
ATOM   330  N N     . CYS A 1 200 ? 40.199  105.733 168.073 1.00 200.80 ? 174 CYS A N     1 
ATOM   331  C CA    . CYS A 1 200 ? 40.514  104.777 169.130 1.00 192.76 ? 174 CYS A CA    1 
ATOM   332  C C     . CYS A 1 200 ? 40.773  105.518 170.434 1.00 166.96 ? 174 CYS A C     1 
ATOM   333  O O     . CYS A 1 200 ? 40.176  105.169 171.449 1.00 152.65 ? 174 CYS A O     1 
ATOM   334  C CB    . CYS A 1 200 ? 41.737  103.927 168.803 1.00 202.63 ? 174 CYS A CB    1 
ATOM   335  S SG    . CYS A 1 200 ? 41.981  102.551 169.956 1.00 211.98 ? 174 CYS A SG    1 
ATOM   336  N N     . LYS A 1 201 ? 41.620  106.559 170.341 1.00 150.94 ? 175 LYS A N     1 
ATOM   337  C CA    . LYS A 1 201 ? 42.157  107.307 171.470 1.00 157.80 ? 175 LYS A CA    1 
ATOM   338  C C     . LYS A 1 201 ? 41.074  108.113 172.207 1.00 172.45 ? 175 LYS A C     1 
ATOM   339  O O     . LYS A 1 201 ? 41.215  108.415 173.399 1.00 151.63 ? 175 LYS A O     1 
ATOM   340  C CB    . LYS A 1 201 ? 43.294  108.166 170.910 1.00 149.39 ? 175 LYS A CB    1 
ATOM   341  C CG    . LYS A 1 201 ? 42.838  109.339 170.044 1.00 152.45 ? 175 LYS A CG    1 
ATOM   342  C CD    . LYS A 1 201 ? 43.956  110.126 169.359 1.00 198.65 ? 175 LYS A CD    1 
ATOM   343  C CE    . LYS A 1 201 ? 43.765  111.634 169.188 1.00 197.75 ? 175 LYS A CE    1 
ATOM   344  N NZ    . LYS A 1 201 ? 42.480  112.114 168.670 1.00 159.68 ? 175 LYS A NZ    1 
ATOM   345  N N     . THR A 1 202 ? 39.988  108.462 171.504 1.00 200.08 ? 176 THR A N     1 
ATOM   346  C CA    . THR A 1 202 ? 38.847  109.121 172.127 1.00 250.76 ? 176 THR A CA    1 
ATOM   347  C C     . THR A 1 202 ? 37.915  108.083 172.756 1.00 244.13 ? 176 THR A C     1 
ATOM   348  O O     . THR A 1 202 ? 37.165  108.410 173.675 1.00 208.43 ? 176 THR A O     1 
ATOM   349  C CB    . THR A 1 202 ? 38.106  109.982 171.101 1.00 288.89 ? 176 THR A CB    1 
ATOM   350  O OG1   . THR A 1 202 ? 37.669  109.104 170.068 1.00 295.50 ? 176 THR A OG1   1 
ATOM   351  C CG2   . THR A 1 202 ? 38.975  111.089 170.529 1.00 295.48 ? 176 THR A CG2   1 
ATOM   352  N N     . LEU A 1 203 ? 37.975  106.839 172.256 1.00 249.26 ? 177 LEU A N     1 
ATOM   353  C CA    . LEU A 1 203 ? 37.035  105.796 172.641 1.00 254.25 ? 177 LEU A CA    1 
ATOM   354  C C     . LEU A 1 203 ? 37.635  104.861 173.698 1.00 294.51 ? 177 LEU A C     1 
ATOM   355  O O     . LEU A 1 203 ? 36.886  104.300 174.497 1.00 320.67 ? 177 LEU A O     1 
ATOM   356  C CB    . LEU A 1 203 ? 36.572  105.039 171.397 1.00 228.02 ? 177 LEU A CB    1 
ATOM   357  C CG    . LEU A 1 203 ? 35.170  104.416 171.470 1.00 260.08 ? 177 LEU A CG    1 
ATOM   358  C CD1   . LEU A 1 203 ? 34.640  104.143 170.067 1.00 282.38 ? 177 LEU A CD1   1 
ATOM   359  C CD2   . LEU A 1 203 ? 35.115  103.133 172.301 1.00 260.76 ? 177 LEU A CD2   1 
ATOM   360  N N     . GLN A 1 204 ? 38.968  104.676 173.716 1.00 277.92 ? 178 GLN A N     1 
ATOM   361  C CA    . GLN A 1 204 ? 39.599  103.885 174.769 1.00 242.75 ? 178 GLN A CA    1 
ATOM   362  C C     . GLN A 1 204 ? 39.287  104.536 176.114 1.00 207.87 ? 178 GLN A C     1 
ATOM   363  O O     . GLN A 1 204 ? 38.853  103.856 177.043 1.00 235.76 ? 178 GLN A O     1 
ATOM   364  C CB    . GLN A 1 204 ? 41.114  103.647 174.667 1.00 239.70 ? 178 GLN A CB    1 
ATOM   365  C CG    . GLN A 1 204 ? 41.975  104.901 174.496 1.00 239.24 ? 178 GLN A CG    1 
ATOM   366  C CD    . GLN A 1 204 ? 43.428  104.760 174.928 1.00 197.70 ? 178 GLN A CD    1 
ATOM   367  O OE1   . GLN A 1 204 ? 44.326  104.530 174.106 1.00 165.46 ? 178 GLN A OE1   1 
ATOM   368  N NE2   . GLN A 1 204 ? 43.689  104.938 176.220 1.00 143.90 ? 178 GLN A NE2   1 
ATOM   369  N N     . ASN A 1 205 ? 39.486  105.857 176.190 1.00 163.24 ? 179 ASN A N     1 
ATOM   370  C CA    . ASN A 1 205 ? 39.207  106.613 177.396 1.00 201.36 ? 179 ASN A CA    1 
ATOM   371  C C     . ASN A 1 205 ? 37.922  107.415 177.194 1.00 209.32 ? 179 ASN A C     1 
ATOM   372  O O     . ASN A 1 205 ? 37.919  108.418 176.471 1.00 195.09 ? 179 ASN A O     1 
ATOM   373  C CB    . ASN A 1 205 ? 40.387  107.502 177.773 1.00 237.88 ? 179 ASN A CB    1 
ATOM   374  C CG    . ASN A 1 205 ? 41.636  106.711 178.094 1.00 238.17 ? 179 ASN A CG    1 
ATOM   375  O OD1   . ASN A 1 205 ? 41.997  105.797 177.349 1.00 203.18 ? 179 ASN A OD1   1 
ATOM   376  N ND2   . ASN A 1 205 ? 42.307  107.032 179.193 1.00 249.54 ? 179 ASN A ND2   1 
ATOM   377  N N     . ARG A 1 206 ? 36.838  106.954 177.842 1.00 192.80 ? 180 ARG A N     1 
ATOM   378  C CA    . ARG A 1 206 ? 35.517  107.526 177.633 1.00 210.94 ? 180 ARG A CA    1 
ATOM   379  C C     . ARG A 1 206 ? 34.552  107.092 178.739 1.00 134.82 ? 180 ARG A C     1 
ATOM   380  O O     . ARG A 1 206 ? 33.921  106.034 178.641 1.00 119.55 ? 180 ARG A O     1 
ATOM   381  C CB    . ARG A 1 206 ? 35.007  107.110 176.242 1.00 288.61 ? 180 ARG A CB    1 
ATOM   382  C CG    . ARG A 1 206 ? 33.711  107.744 175.747 1.00 305.88 ? 180 ARG A CG    1 
ATOM   383  C CD    . ARG A 1 206 ? 33.856  109.237 175.465 1.00 280.97 ? 180 ARG A CD    1 
ATOM   384  N NE    . ARG A 1 206 ? 32.573  109.947 175.525 1.00 211.85 ? 180 ARG A NE    1 
ATOM   385  C CZ    . ARG A 1 206 ? 32.424  111.076 176.197 1.00 150.36 ? 180 ARG A CZ    1 
ATOM   386  N NH1   . ARG A 1 206 ? 33.519  111.742 176.541 1.00 124.64 ? 180 ARG A NH1   1 
ATOM   387  N NH2   . ARG A 1 206 ? 31.213  111.538 176.494 1.00 151.85 ? 180 ARG A NH2   1 
ATOM   388  N N     . GLU A 1 207 ? 34.434  107.946 179.762 1.00 113.13 ? 181 GLU A N     1 
ATOM   389  C CA    . GLU A 1 207 ? 33.343  107.919 180.738 1.00 163.51 ? 181 GLU A CA    1 
ATOM   390  C C     . GLU A 1 207 ? 33.753  108.835 181.901 1.00 169.05 ? 181 GLU A C     1 
ATOM   391  O O     . GLU A 1 207 ? 33.437  108.555 183.067 1.00 169.54 ? 181 GLU A O     1 
ATOM   392  C CB    . GLU A 1 207 ? 33.000  106.499 181.238 1.00 236.41 ? 181 GLU A CB    1 
ATOM   393  C CG    . GLU A 1 207 ? 31.519  106.201 181.511 1.00 240.48 ? 181 GLU A CG    1 
ATOM   394  C CD    . GLU A 1 207 ? 31.080  104.755 181.836 1.00 214.81 ? 181 GLU A CD    1 
ATOM   395  O OE1   . GLU A 1 207 ? 31.336  103.747 181.083 1.00 125.53 ? 181 GLU A OE1   1 
ATOM   396  O OE2   . GLU A 1 207 ? 30.397  104.663 182.896 1.00 161.04 ? 181 GLU A OE2   1 
ATOM   397  N N     . HIS A 1 208 ? 34.460  109.935 181.556 1.00 126.54 ? 182 HIS A N     1 
ATOM   398  C CA    . HIS A 1 208 ? 35.171  110.800 182.502 1.00 128.46 ? 182 HIS A CA    1 
ATOM   399  C C     . HIS A 1 208 ? 34.495  112.171 182.630 1.00 135.54 ? 182 HIS A C     1 
ATOM   400  O O     . HIS A 1 208 ? 35.208  113.178 182.758 1.00 112.71 ? 182 HIS A O     1 
ATOM   401  C CB    . HIS A 1 208 ? 36.640  111.007 182.079 1.00 119.99 ? 182 HIS A CB    1 
ATOM   402  C CG    . HIS A 1 208 ? 37.369  109.724 181.756 1.00 183.18 ? 182 HIS A CG    1 
ATOM   403  N ND1   . HIS A 1 208 ? 37.001  108.855 180.741 1.00 145.56 ? 182 HIS A ND1   1 
ATOM   404  C CD2   . HIS A 1 208 ? 38.432  109.152 182.362 1.00 209.23 ? 182 HIS A CD2   1 
ATOM   405  C CE1   . HIS A 1 208 ? 37.820  107.812 180.736 1.00 160.87 ? 182 HIS A CE1   1 
ATOM   406  N NE2   . HIS A 1 208 ? 38.700  107.974 181.709 1.00 196.66 ? 182 HIS A NE2   1 
ATOM   407  N N     . GLU A 1 209 ? 33.138  112.173 182.604 1.00 153.55 ? 183 GLU A N     1 
ATOM   408  C CA    . GLU A 1 209 ? 32.284  113.343 182.372 1.00 170.51 ? 183 GLU A CA    1 
ATOM   409  C C     . GLU A 1 209 ? 30.832  112.938 182.722 1.00 156.43 ? 183 GLU A C     1 
ATOM   410  O O     . GLU A 1 209 ? 29.897  113.715 182.375 1.00 130.82 ? 183 GLU A O     1 
ATOM   411  C CB    . GLU A 1 209 ? 32.274  113.919 180.939 1.00 182.65 ? 183 GLU A CB    1 
ATOM   412  C CG    . GLU A 1 209 ? 33.567  114.576 180.425 1.00 180.31 ? 183 GLU A CG    1 
ATOM   413  C CD    . GLU A 1 209 ? 33.852  114.543 178.910 1.00 148.17 ? 183 GLU A CD    1 
ATOM   414  O OE1   . GLU A 1 209 ? 32.880  114.894 178.187 1.00 133.37 ? 183 GLU A OE1   1 
ATOM   415  O OE2   . GLU A 1 209 ? 34.994  114.165 178.446 1.00 90.05  ? 183 GLU A OE2   1 
ATOM   416  N N     . GLN A 1 220 ? 19.801  99.625  168.286 1.00 129.59 ? 194 GLN A N     1 
ATOM   417  C CA    . GLN A 1 220 ? 21.044  100.450 168.210 1.00 161.29 ? 194 GLN A CA    1 
ATOM   418  C C     . GLN A 1 220 ? 22.260  99.625  168.640 1.00 164.10 ? 194 GLN A C     1 
ATOM   419  O O     . GLN A 1 220 ? 22.541  99.515  169.832 1.00 242.67 ? 194 GLN A O     1 
ATOM   420  C CB    . GLN A 1 220 ? 20.965  101.738 169.046 1.00 191.66 ? 194 GLN A CB    1 
ATOM   421  C CG    . GLN A 1 220 ? 19.732  102.599 168.750 1.00 232.35 ? 194 GLN A CG    1 
ATOM   422  C CD    . GLN A 1 220 ? 19.741  104.037 169.256 1.00 217.26 ? 194 GLN A CD    1 
ATOM   423  O OE1   . GLN A 1 220 ? 20.663  104.520 169.937 1.00 176.98 ? 194 GLN A OE1   1 
ATOM   424  N NE2   . GLN A 1 220 ? 18.683  104.758 168.890 1.00 220.14 ? 194 GLN A NE2   1 
ATOM   425  N N     . GLU A 1 221 ? 22.990  99.065  167.663 1.00 159.03 ? 195 GLU A N     1 
ATOM   426  C CA    . GLU A 1 221 ? 24.218  98.315  167.908 1.00 158.49 ? 195 GLU A CA    1 
ATOM   427  C C     . GLU A 1 221 ? 25.426  99.207  167.635 1.00 174.13 ? 195 GLU A C     1 
ATOM   428  O O     . GLU A 1 221 ? 25.934  99.902  168.519 1.00 172.62 ? 195 GLU A O     1 
ATOM   429  C CB    . GLU A 1 221 ? 24.327  97.090  166.988 1.00 130.59 ? 195 GLU A CB    1 
ATOM   430  N N     . GLN A 1 222 ? 25.798  99.193  166.349 1.00 213.04 ? 196 GLN A N     1 
ATOM   431  C CA    . GLN A 1 222 ? 27.065  99.662  165.819 1.00 199.05 ? 196 GLN A CA    1 
ATOM   432  C C     . GLN A 1 222 ? 28.103  98.529  165.923 1.00 184.52 ? 196 GLN A C     1 
ATOM   433  O O     . GLN A 1 222 ? 27.772  97.393  166.297 1.00 103.70 ? 196 GLN A O     1 
ATOM   434  C CB    . GLN A 1 222 ? 27.394  101.029 166.433 1.00 170.26 ? 196 GLN A CB    1 
ATOM   435  C CG    . GLN A 1 222 ? 28.152  101.949 165.481 1.00 194.92 ? 196 GLN A CG    1 
ATOM   436  C CD    . GLN A 1 222 ? 29.194  102.820 166.149 1.00 200.32 ? 196 GLN A CD    1 
ATOM   437  O OE1   . GLN A 1 222 ? 30.394  102.689 165.879 1.00 180.55 ? 196 GLN A OE1   1 
ATOM   438  N NE2   . GLN A 1 222 ? 28.746  103.729 167.008 1.00 193.36 ? 196 GLN A NE2   1 
ATOM   439  N N     . LEU A 1 223 ? 29.302  98.824  165.391 1.00 177.76 ? 197 LEU A N     1 
ATOM   440  C CA    . LEU A 1 223 ? 30.591  98.366  165.899 1.00 173.06 ? 197 LEU A CA    1 
ATOM   441  C C     . LEU A 1 223 ? 31.658  98.898  164.938 1.00 165.97 ? 197 LEU A C     1 
ATOM   442  O O     . LEU A 1 223 ? 31.757  98.434  163.804 1.00 146.46 ? 197 LEU A O     1 
ATOM   443  C CB    . LEU A 1 223 ? 30.733  96.861  166.149 1.00 147.13 ? 197 LEU A CB    1 
ATOM   444  N N     . LEU A 1 224 ? 32.405  99.914  165.406 1.00 206.22 ? 198 LEU A N     1 
ATOM   445  C CA    . LEU A 1 224 ? 33.454  100.584 164.644 1.00 209.47 ? 198 LEU A CA    1 
ATOM   446  C C     . LEU A 1 224 ? 34.773  99.853  164.860 1.00 203.76 ? 198 LEU A C     1 
ATOM   447  O O     . LEU A 1 224 ? 35.461  99.499  163.900 1.00 128.41 ? 198 LEU A O     1 
ATOM   448  C CB    . LEU A 1 224 ? 33.599  102.049 165.069 1.00 197.46 ? 198 LEU A CB    1 
ATOM   449  N N     . LEU A 1 225 ? 35.082  99.640  166.146 1.00 220.32 ? 199 LEU A N     1 
ATOM   450  C CA    . LEU A 1 225 ? 36.404  99.251  166.598 1.00 226.84 ? 199 LEU A CA    1 
ATOM   451  C C     . LEU A 1 225 ? 36.777  97.855  166.087 1.00 250.73 ? 199 LEU A C     1 
ATOM   452  O O     . LEU A 1 225 ? 37.913  97.663  165.651 1.00 218.10 ? 199 LEU A O     1 
ATOM   453  C CB    . LEU A 1 225 ? 36.378  99.359  168.122 1.00 184.20 ? 199 LEU A CB    1 
ATOM   454  N N     . LYS A 1 226 ? 35.817  96.906  166.122 1.00 241.65 ? 200 LYS A N     1 
ATOM   455  C CA    . LYS A 1 226 ? 36.048  95.511  165.749 1.00 178.66 ? 200 LYS A CA    1 
ATOM   456  C C     . LYS A 1 226 ? 36.177  95.391  164.234 1.00 181.30 ? 200 LYS A C     1 
ATOM   457  O O     . LYS A 1 226 ? 37.133  94.764  163.784 1.00 188.15 ? 200 LYS A O     1 
ATOM   458  C CB    . LYS A 1 226 ? 34.952  94.571  166.267 1.00 140.78 ? 200 LYS A CB    1 
ATOM   459  C CG    . LYS A 1 226 ? 34.939  93.139  165.734 1.00 136.98 ? 200 LYS A CG    1 
ATOM   460  C CD    . LYS A 1 226 ? 33.843  92.210  166.288 1.00 162.39 ? 200 LYS A CD    1 
ATOM   461  C CE    . LYS A 1 226 ? 32.482  92.831  166.606 1.00 171.07 ? 200 LYS A CE    1 
ATOM   462  N NZ    . LYS A 1 226 ? 31.475  91.932  167.197 1.00 149.66 ? 200 LYS A NZ    1 
ATOM   463  N N     . LYS A 1 227 ? 35.222  95.974  163.474 1.00 180.46 ? 201 LYS A N     1 
ATOM   464  C CA    . LYS A 1 227 ? 35.243  95.964  162.007 1.00 186.63 ? 201 LYS A CA    1 
ATOM   465  C C     . LYS A 1 227 ? 35.648  97.343  161.491 1.00 153.47 ? 201 LYS A C     1 
ATOM   466  O O     . LYS A 1 227 ? 34.820  98.242  161.400 1.00 170.46 ? 201 LYS A O     1 
ATOM   467  C CB    . LYS A 1 227 ? 33.919  95.613  161.299 1.00 184.15 ? 201 LYS A CB    1 
ATOM   468  C CG    . LYS A 1 227 ? 33.533  94.127  161.106 1.00 141.81 ? 201 LYS A CG    1 
ATOM   469  C CD    . LYS A 1 227 ? 32.025  93.878  161.240 1.00 143.59 ? 201 LYS A CD    1 
ATOM   470  C CE    . LYS A 1 227 ? 31.298  94.533  162.443 1.00 115.52 ? 201 LYS A CE    1 
ATOM   471  N NZ    . LYS A 1 227 ? 29.870  94.215  162.661 1.00 109.59 ? 201 LYS A NZ    1 
ATOM   472  N N     . MET A 1 228 ? 36.918  97.467  161.107 1.00 143.28 ? 202 MET A N     1 
ATOM   473  C CA    . MET A 1 228 ? 37.524  98.730  160.726 1.00 172.29 ? 202 MET A CA    1 
ATOM   474  C C     . MET A 1 228 ? 39.011  98.608  161.039 1.00 179.73 ? 202 MET A C     1 
ATOM   475  O O     . MET A 1 228 ? 39.879  98.787  160.176 1.00 130.60 ? 202 MET A O     1 
ATOM   476  C CB    . MET A 1 228 ? 36.933  99.934  161.479 1.00 182.32 ? 202 MET A CB    1 
ATOM   477  C CG    . MET A 1 228 ? 37.496  101.289 161.044 1.00 218.12 ? 202 MET A CG    1 
ATOM   478  S SD    . MET A 1 228 ? 39.182  101.649 161.592 1.00 197.41 ? 202 MET A SD    1 
ATOM   479  C CE    . MET A 1 228 ? 38.897  103.260 162.337 1.00 178.13 ? 202 MET A CE    1 
ATOM   480  N N     . TYR A 1 229 ? 39.277  98.297  162.312 1.00 197.84 ? 203 TYR A N     1 
ATOM   481  C CA    . TYR A 1 229 ? 40.552  97.715  162.680 1.00 215.99 ? 203 TYR A CA    1 
ATOM   482  C C     . TYR A 1 229 ? 40.950  96.797  161.522 1.00 178.07 ? 203 TYR A C     1 
ATOM   483  O O     . TYR A 1 229 ? 41.994  96.950  160.879 1.00 124.10 ? 203 TYR A O     1 
ATOM   484  C CB    . TYR A 1 229 ? 40.421  97.051  164.064 1.00 199.24 ? 203 TYR A CB    1 
ATOM   485  C CG    . TYR A 1 229 ? 41.561  96.086  164.367 1.00 176.20 ? 203 TYR A CG    1 
ATOM   486  C CD1   . TYR A 1 229 ? 42.821  96.557  164.717 1.00 153.63 ? 203 TYR A CD1   1 
ATOM   487  C CD2   . TYR A 1 229 ? 41.403  94.710  164.243 1.00 174.24 ? 203 TYR A CD2   1 
ATOM   488  C CE1   . TYR A 1 229 ? 43.885  95.696  164.933 1.00 141.14 ? 203 TYR A CE1   1 
ATOM   489  C CE2   . TYR A 1 229 ? 42.458  93.838  164.472 1.00 176.83 ? 203 TYR A CE2   1 
ATOM   490  C CZ    . TYR A 1 229 ? 43.708  94.331  164.813 1.00 152.05 ? 203 TYR A CZ    1 
ATOM   491  O OH    . TYR A 1 229 ? 44.780  93.517  165.052 1.00 117.95 ? 203 TYR A OH    1 
ATOM   492  N N     . LEU A 1 230 ? 40.045  95.877  161.206 1.00 169.90 ? 204 LEU A N     1 
ATOM   493  C CA    . LEU A 1 230 ? 40.312  94.922  160.154 1.00 209.58 ? 204 LEU A CA    1 
ATOM   494  C C     . LEU A 1 230 ? 41.131  95.607  159.063 1.00 231.15 ? 204 LEU A C     1 
ATOM   495  O O     . LEU A 1 230 ? 42.119  95.046  158.594 1.00 238.55 ? 204 LEU A O     1 
ATOM   496  C CB    . LEU A 1 230 ? 39.015  94.321  159.617 1.00 192.49 ? 204 LEU A CB    1 
ATOM   497  C CG    . LEU A 1 230 ? 39.133  92.858  159.175 1.00 192.17 ? 204 LEU A CG    1 
ATOM   498  C CD1   . LEU A 1 230 ? 39.144  91.888  160.354 1.00 175.70 ? 204 LEU A CD1   1 
ATOM   499  C CD2   . LEU A 1 230 ? 38.035  92.485  158.221 1.00 224.60 ? 204 LEU A CD2   1 
ATOM   500  N N     . MET A 1 231 ? 40.737  96.836  158.703 1.00 229.35 ? 205 MET A N     1 
ATOM   501  C CA    . MET A 1 231 ? 41.360  97.547  157.599 1.00 219.16 ? 205 MET A CA    1 
ATOM   502  C C     . MET A 1 231 ? 42.809  97.885  157.917 1.00 176.32 ? 205 MET A C     1 
ATOM   503  O O     . MET A 1 231 ? 43.646  97.813  157.018 1.00 182.98 ? 205 MET A O     1 
ATOM   504  C CB    . MET A 1 231 ? 40.613  98.834  157.248 1.00 223.11 ? 205 MET A CB    1 
ATOM   505  C CG    . MET A 1 231 ? 39.170  98.599  156.853 1.00 238.83 ? 205 MET A CG    1 
ATOM   506  S SD    . MET A 1 231 ? 38.951  97.377  155.541 1.00 212.59 ? 205 MET A SD    1 
ATOM   507  C CE    . MET A 1 231 ? 37.152  97.335  155.480 1.00 190.45 ? 205 MET A CE    1 
ATOM   508  N N     . LEU A 1 232 ? 43.111  98.231  159.172 1.00 119.65 ? 206 LEU A N     1 
ATOM   509  C CA    . LEU A 1 232 ? 44.512  98.374  159.524 1.00 133.02 ? 206 LEU A CA    1 
ATOM   510  C C     . LEU A 1 232 ? 45.258  97.054  159.348 1.00 180.54 ? 206 LEU A C     1 
ATOM   511  O O     . LEU A 1 232 ? 46.482  97.092  159.216 1.00 199.57 ? 206 LEU A O     1 
ATOM   512  C CB    . LEU A 1 232 ? 44.784  98.870  160.930 1.00 121.61 ? 206 LEU A CB    1 
ATOM   513  C CG    . LEU A 1 232 ? 44.756  100.370 161.143 1.00 134.61 ? 206 LEU A CG    1 
ATOM   514  C CD1   . LEU A 1 232 ? 45.729  100.559 162.332 1.00 114.65 ? 206 LEU A CD1   1 
ATOM   515  C CD2   . LEU A 1 232 ? 45.067  101.142 159.848 1.00 135.93 ? 206 LEU A CD2   1 
ATOM   516  N N     . ASP A 1 233 ? 44.567  95.901  159.407 1.00 137.67 ? 207 ASP A N     1 
ATOM   517  C CA    . ASP A 1 233 ? 45.181  94.711  158.844 1.00 132.95 ? 207 ASP A CA    1 
ATOM   518  C C     . ASP A 1 233 ? 45.039  94.822  157.318 1.00 144.15 ? 207 ASP A C     1 
ATOM   519  O O     . ASP A 1 233 ? 45.956  95.275  156.620 1.00 117.50 ? 207 ASP A O     1 
ATOM   520  C CB    . ASP A 1 233 ? 44.760  93.441  159.573 1.00 152.92 ? 207 ASP A CB    1 
ATOM   521  C CG    . ASP A 1 233 ? 45.767  92.285  159.556 1.00 181.65 ? 207 ASP A CG    1 
ATOM   522  O OD1   . ASP A 1 233 ? 46.993  92.551  159.617 1.00 133.96 ? 207 ASP A OD1   1 
ATOM   523  O OD2   . ASP A 1 233 ? 45.327  91.104  159.516 1.00 182.63 ? 207 ASP A OD2   1 
ATOM   524  N N     . ASN A 1 234 ? 43.859  94.496  156.791 1.00 135.58 ? 208 ASN A N     1 
ATOM   525  C CA    . ASN A 1 234 ? 43.687  94.440  155.347 1.00 130.22 ? 208 ASN A CA    1 
ATOM   526  C C     . ASN A 1 234 ? 44.651  95.381  154.650 1.00 106.36 ? 208 ASN A C     1 
ATOM   527  O O     . ASN A 1 234 ? 45.467  94.918  153.849 1.00 115.50 ? 208 ASN A O     1 
ATOM   528  C CB    . ASN A 1 234 ? 42.238  94.620  154.941 1.00 131.57 ? 208 ASN A CB    1 
ATOM   529  C CG    . ASN A 1 234 ? 41.504  93.374  155.382 1.00 199.91 ? 208 ASN A CG    1 
ATOM   530  O OD1   . ASN A 1 234 ? 41.415  93.105  156.590 1.00 167.69 ? 208 ASN A OD1   1 
ATOM   531  N ND2   . ASN A 1 234 ? 41.070  92.553  154.433 1.00 223.57 ? 208 ASN A ND2   1 
ATOM   532  N N     . LYS A 1 235 ? 44.588  96.672  154.972 1.00 89.24  ? 209 LYS A N     1 
ATOM   533  C CA    . LYS A 1 235 ? 45.284  97.597  154.105 1.00 100.19 ? 209 LYS A CA    1 
ATOM   534  C C     . LYS A 1 235 ? 46.765  97.282  154.132 1.00 102.07 ? 209 LYS A C     1 
ATOM   535  O O     . LYS A 1 235 ? 47.389  97.362  153.074 1.00 101.61 ? 209 LYS A O     1 
ATOM   536  C CB    . LYS A 1 235 ? 45.016  99.093  154.262 1.00 142.19 ? 209 LYS A CB    1 
ATOM   537  C CG    . LYS A 1 235 ? 44.036  99.638  153.200 1.00 176.07 ? 209 LYS A CG    1 
ATOM   538  C CD    . LYS A 1 235 ? 44.587  99.839  151.789 1.00 157.67 ? 209 LYS A CD    1 
ATOM   539  C CE    . LYS A 1 235 ? 45.071  101.245 151.578 1.00 143.71 ? 209 LYS A CE    1 
ATOM   540  N NZ    . LYS A 1 235 ? 46.028  101.320 150.472 1.00 121.94 ? 209 LYS A NZ    1 
ATOM   541  N N     . ARG A 1 236 ? 47.305  96.870  155.286 1.00 94.30  ? 210 ARG A N     1 
ATOM   542  C CA    . ARG A 1 236 ? 48.748  96.650  155.383 1.00 113.33 ? 210 ARG A CA    1 
ATOM   543  C C     . ARG A 1 236 ? 49.235  95.422  154.591 1.00 96.74  ? 210 ARG A C     1 
ATOM   544  O O     . ARG A 1 236 ? 50.282  95.443  153.869 1.00 55.31  ? 210 ARG A O     1 
ATOM   545  C CB    . ARG A 1 236 ? 49.177  96.523  156.844 1.00 126.73 ? 210 ARG A CB    1 
ATOM   546  C CG    . ARG A 1 236 ? 49.207  97.785  157.697 1.00 118.42 ? 210 ARG A CG    1 
ATOM   547  C CD    . ARG A 1 236 ? 50.178  97.466  158.842 1.00 118.88 ? 210 ARG A CD    1 
ATOM   548  N NE    . ARG A 1 236 ? 49.681  97.838  160.170 1.00 105.87 ? 210 ARG A NE    1 
ATOM   549  C CZ    . ARG A 1 236 ? 50.385  98.506  161.085 1.00 133.25 ? 210 ARG A CZ    1 
ATOM   550  N NH1   . ARG A 1 236 ? 51.647  98.849  160.880 1.00 118.34 ? 210 ARG A NH1   1 
ATOM   551  N NH2   . ARG A 1 236 ? 49.816  98.842  162.232 1.00 157.39 ? 210 ARG A NH2   1 
ATOM   552  N N     . LYS A 1 237 ? 48.448  94.356  154.761 1.00 86.08  ? 211 LYS A N     1 
ATOM   553  C CA    . LYS A 1 237 ? 48.596  93.201  153.911 1.00 117.59 ? 211 LYS A CA    1 
ATOM   554  C C     . LYS A 1 237 ? 48.622  93.612  152.436 1.00 127.81 ? 211 LYS A C     1 
ATOM   555  O O     . LYS A 1 237 ? 49.642  93.393  151.777 1.00 129.90 ? 211 LYS A O     1 
ATOM   556  C CB    . LYS A 1 237 ? 47.548  92.152  154.276 1.00 151.74 ? 211 LYS A CB    1 
ATOM   557  C CG    . LYS A 1 237 ? 47.925  91.237  155.450 1.00 145.73 ? 211 LYS A CG    1 
ATOM   558  C CD    . LYS A 1 237 ? 47.168  89.907  155.404 1.00 158.16 ? 211 LYS A CD    1 
ATOM   559  C CE    . LYS A 1 237 ? 45.730  90.040  155.874 1.00 157.20 ? 211 LYS A CE    1 
ATOM   560  N NZ    . LYS A 1 237 ? 44.716  89.386  155.035 1.00 149.02 ? 211 LYS A NZ    1 
ATOM   561  N N     . GLU A 1 238 ? 47.534  94.198  151.913 1.00 99.42  ? 212 GLU A N     1 
ATOM   562  C CA    . GLU A 1 238 ? 47.574  94.718  150.546 1.00 133.90 ? 212 GLU A CA    1 
ATOM   563  C C     . GLU A 1 238 ? 48.814  95.583  150.224 1.00 113.51 ? 212 GLU A C     1 
ATOM   564  O O     . GLU A 1 238 ? 49.395  95.417  149.154 1.00 112.45 ? 212 GLU A O     1 
ATOM   565  C CB    . GLU A 1 238 ? 46.297  95.467  150.164 1.00 193.80 ? 212 GLU A CB    1 
ATOM   566  C CG    . GLU A 1 238 ? 45.425  94.730  149.144 1.00 238.65 ? 212 GLU A CG    1 
ATOM   567  C CD    . GLU A 1 238 ? 45.678  95.028  147.668 1.00 247.53 ? 212 GLU A CD    1 
ATOM   568  O OE1   . GLU A 1 238 ? 46.497  95.925  147.369 1.00 252.44 ? 212 GLU A OE1   1 
ATOM   569  O OE2   . GLU A 1 238 ? 45.040  94.368  146.809 1.00 209.78 ? 212 GLU A OE2   1 
ATOM   570  N N     . VAL A 1 239 ? 49.247  96.506  151.096 1.00 81.21  ? 213 VAL A N     1 
ATOM   571  C CA    . VAL A 1 239 ? 50.451  97.261  150.792 1.00 80.22  ? 213 VAL A CA    1 
ATOM   572  C C     . VAL A 1 239 ? 51.627  96.308  150.609 1.00 107.80 ? 213 VAL A C     1 
ATOM   573  O O     . VAL A 1 239 ? 52.309  96.434  149.562 1.00 78.50  ? 213 VAL A O     1 
ATOM   574  C CB    . VAL A 1 239 ? 50.834  98.330  151.829 1.00 88.27  ? 213 VAL A CB    1 
ATOM   575  C CG1   . VAL A 1 239 ? 52.199  99.004  151.609 1.00 73.31  ? 213 VAL A CG1   1 
ATOM   576  C CG2   . VAL A 1 239 ? 49.773  99.408  151.886 1.00 104.47 ? 213 VAL A CG2   1 
ATOM   577  N N     . VAL A 1 240 ? 51.868  95.430  151.632 1.00 85.14  ? 214 VAL A N     1 
ATOM   578  C CA    . VAL A 1 240 ? 53.089  94.610  151.672 1.00 101.67 ? 214 VAL A CA    1 
ATOM   579  C C     . VAL A 1 240 ? 53.202  93.656  150.482 1.00 98.69  ? 214 VAL A C     1 
ATOM   580  O O     . VAL A 1 240 ? 54.279  93.497  149.883 1.00 67.24  ? 214 VAL A O     1 
ATOM   581  C CB    . VAL A 1 240 ? 53.340  93.678  152.857 1.00 88.87  ? 214 VAL A CB    1 
ATOM   582  C CG1   . VAL A 1 240 ? 52.615  92.366  152.686 1.00 121.75 ? 214 VAL A CG1   1 
ATOM   583  C CG2   . VAL A 1 240 ? 54.793  93.283  152.962 1.00 73.84  ? 214 VAL A CG2   1 
ATOM   584  N N     . HIS A 1 241 ? 52.104  92.935  150.256 1.00 98.73  ? 215 HIS A N     1 
ATOM   585  C CA    . HIS A 1 241 ? 52.054  91.984  149.178 1.00 122.25 ? 215 HIS A CA    1 
ATOM   586  C C     . HIS A 1 241 ? 52.352  92.751  147.889 1.00 119.18 ? 215 HIS A C     1 
ATOM   587  O O     . HIS A 1 241 ? 53.128  92.294  147.038 1.00 113.93 ? 215 HIS A O     1 
ATOM   588  C CB    . HIS A 1 241 ? 50.722  91.231  149.245 1.00 150.20 ? 215 HIS A CB    1 
ATOM   589  C CG    . HIS A 1 241 ? 50.264  90.764  147.905 1.00 184.50 ? 215 HIS A CG    1 
ATOM   590  N ND1   . HIS A 1 241 ? 49.792  91.650  146.953 1.00 176.32 ? 215 HIS A ND1   1 
ATOM   591  C CD2   . HIS A 1 241 ? 50.239  89.547  147.345 1.00 161.86 ? 215 HIS A CD2   1 
ATOM   592  C CE1   . HIS A 1 241 ? 49.467  90.978  145.861 1.00 181.57 ? 215 HIS A CE1   1 
ATOM   593  N NE2   . HIS A 1 241 ? 49.734  89.701  146.076 1.00 194.15 ? 215 HIS A NE2   1 
ATOM   594  N N     . LYS A 1 242 ? 51.771  93.949  147.783 1.00 88.37  ? 216 LYS A N     1 
ATOM   595  C CA    . LYS A 1 242 ? 51.935  94.726  146.577 1.00 96.21  ? 216 LYS A CA    1 
ATOM   596  C C     . LYS A 1 242 ? 53.382  95.185  146.333 1.00 93.68  ? 216 LYS A C     1 
ATOM   597  O O     . LYS A 1 242 ? 53.819  95.254  145.178 1.00 86.15  ? 216 LYS A O     1 
ATOM   598  C CB    . LYS A 1 242 ? 50.948  95.882  146.594 1.00 129.85 ? 216 LYS A CB    1 
ATOM   599  C CG    . LYS A 1 242 ? 50.513  96.263  145.187 1.00 162.82 ? 216 LYS A CG    1 
ATOM   600  C CD    . LYS A 1 242 ? 49.509  97.408  145.215 1.00 168.42 ? 216 LYS A CD    1 
ATOM   601  C CE    . LYS A 1 242 ? 49.032  97.785  143.859 1.00 147.96 ? 216 LYS A CE    1 
ATOM   602  N NZ    . LYS A 1 242 ? 48.706  99.206  143.858 1.00 129.82 ? 216 LYS A NZ    1 
ATOM   603  N N     . ILE A 1 243 ? 54.158  95.532  147.364 1.00 90.41  ? 217 ILE A N     1 
ATOM   604  C CA    . ILE A 1 243 ? 55.554  95.800  147.067 1.00 87.14  ? 217 ILE A CA    1 
ATOM   605  C C     . ILE A 1 243 ? 56.178  94.557  146.449 1.00 121.22 ? 217 ILE A C     1 
ATOM   606  O O     . ILE A 1 243 ? 56.911  94.655  145.454 1.00 106.41 ? 217 ILE A O     1 
ATOM   607  C CB    . ILE A 1 243 ? 56.363  96.195  148.296 1.00 71.63  ? 217 ILE A CB    1 
ATOM   608  C CG1   . ILE A 1 243 ? 56.009  97.543  148.764 1.00 65.37  ? 217 ILE A CG1   1 
ATOM   609  C CG2   . ILE A 1 243 ? 57.851  96.145  147.972 1.00 69.57  ? 217 ILE A CG2   1 
ATOM   610  C CD1   . ILE A 1 243 ? 56.994  97.980  149.840 1.00 62.70  ? 217 ILE A CD1   1 
ATOM   611  N N     . ILE A 1 244 ? 55.939  93.407  147.104 1.00 124.01 ? 218 ILE A N     1 
ATOM   612  C CA    . ILE A 1 244 ? 56.591  92.183  146.681 1.00 104.20 ? 218 ILE A CA    1 
ATOM   613  C C     . ILE A 1 244 ? 56.349  92.001  145.196 1.00 93.36  ? 218 ILE A C     1 
ATOM   614  O O     . ILE A 1 244 ? 57.325  91.808  144.478 1.00 101.88 ? 218 ILE A O     1 
ATOM   615  C CB    . ILE A 1 244 ? 56.182  90.951  147.484 1.00 87.84  ? 218 ILE A CB    1 
ATOM   616  C CG1   . ILE A 1 244 ? 56.703  91.071  148.885 1.00 121.04 ? 218 ILE A CG1   1 
ATOM   617  C CG2   . ILE A 1 244 ? 56.705  89.702  146.791 1.00 88.86  ? 218 ILE A CG2   1 
ATOM   618  C CD1   . ILE A 1 244 ? 56.490  89.833  149.738 1.00 163.90 ? 218 ILE A CD1   1 
ATOM   619  N N     . GLU A 1 245 ? 55.100  92.124  144.729 1.00 67.93  ? 219 GLU A N     1 
ATOM   620  C CA    . GLU A 1 245 ? 54.931  92.062  143.290 1.00 81.09  ? 219 GLU A CA    1 
ATOM   621  C C     . GLU A 1 245 ? 55.890  92.994  142.541 1.00 88.32  ? 219 GLU A C     1 
ATOM   622  O O     . GLU A 1 245 ? 56.663  92.481  141.730 1.00 94.50  ? 219 GLU A O     1 
ATOM   623  C CB    . GLU A 1 245 ? 53.495  92.210  142.833 1.00 122.14 ? 219 GLU A CB    1 
ATOM   624  C CG    . GLU A 1 245 ? 52.742  90.884  142.947 1.00 175.26 ? 219 GLU A CG    1 
ATOM   625  C CD    . GLU A 1 245 ? 52.455  90.153  141.645 1.00 211.32 ? 219 GLU A CD    1 
ATOM   626  O OE1   . GLU A 1 245 ? 51.829  89.077  141.757 1.00 233.76 ? 219 GLU A OE1   1 
ATOM   627  O OE2   . GLU A 1 245 ? 52.813  90.638  140.544 1.00 221.65 ? 219 GLU A OE2   1 
ATOM   628  N N     . LEU A 1 246 ? 55.904  94.315  142.808 1.00 87.80  ? 220 LEU A N     1 
ATOM   629  C CA    . LEU A 1 246 ? 56.905  95.212  142.210 1.00 73.90  ? 220 LEU A CA    1 
ATOM   630  C C     . LEU A 1 246 ? 58.304  94.623  142.231 1.00 82.23  ? 220 LEU A C     1 
ATOM   631  O O     . LEU A 1 246 ? 58.836  94.434  141.143 1.00 90.14  ? 220 LEU A O     1 
ATOM   632  C CB    . LEU A 1 246 ? 57.039  96.558  142.901 1.00 70.63  ? 220 LEU A CB    1 
ATOM   633  C CG    . LEU A 1 246 ? 58.316  97.379  142.645 1.00 54.14  ? 220 LEU A CG    1 
ATOM   634  C CD1   . LEU A 1 246 ? 58.787  97.554  141.256 1.00 55.35  ? 220 LEU A CD1   1 
ATOM   635  C CD2   . LEU A 1 246 ? 57.960  98.811  143.114 1.00 60.28  ? 220 LEU A CD2   1 
ATOM   636  N N     . LEU A 1 247 ? 58.887  94.376  143.432 1.00 65.51  ? 221 LEU A N     1 
ATOM   637  C CA    . LEU A 1 247 ? 60.230  93.818  143.492 1.00 74.07  ? 221 LEU A CA    1 
ATOM   638  C C     . LEU A 1 247 ? 60.504  92.660  142.523 1.00 90.44  ? 221 LEU A C     1 
ATOM   639  O O     . LEU A 1 247 ? 61.457  92.748  141.746 1.00 114.35 ? 221 LEU A O     1 
ATOM   640  C CB    . LEU A 1 247 ? 60.618  93.421  144.889 1.00 63.41  ? 221 LEU A CB    1 
ATOM   641  C CG    . LEU A 1 247 ? 61.073  94.598  145.748 1.00 82.40  ? 221 LEU A CG    1 
ATOM   642  C CD1   . LEU A 1 247 ? 61.905  94.045  146.896 1.00 109.59 ? 221 LEU A CD1   1 
ATOM   643  C CD2   . LEU A 1 247 ? 61.938  95.633  145.063 1.00 99.46  ? 221 LEU A CD2   1 
ATOM   644  N N     . ASN A 1 248 ? 59.671  91.613  142.534 1.00 90.57  ? 222 ASN A N     1 
ATOM   645  C CA    . ASN A 1 248 ? 59.761  90.495  141.599 1.00 93.54  ? 222 ASN A CA    1 
ATOM   646  C C     . ASN A 1 248 ? 59.849  90.914  140.146 1.00 91.40  ? 222 ASN A C     1 
ATOM   647  O O     . ASN A 1 248 ? 60.654  90.344  139.416 1.00 106.15 ? 222 ASN A O     1 
ATOM   648  C CB    . ASN A 1 248 ? 58.572  89.558  141.701 1.00 103.16 ? 222 ASN A CB    1 
ATOM   649  C CG    . ASN A 1 248 ? 58.649  88.856  143.035 1.00 121.88 ? 222 ASN A CG    1 
ATOM   650  O OD1   . ASN A 1 248 ? 59.514  89.208  143.846 1.00 140.65 ? 222 ASN A OD1   1 
ATOM   651  N ND2   . ASN A 1 248 ? 57.764  87.909  143.311 1.00 123.58 ? 222 ASN A ND2   1 
ATOM   652  N N     . VAL A 1 249 ? 59.011  91.871  139.746 1.00 90.95  ? 223 VAL A N     1 
ATOM   653  C CA    . VAL A 1 249 ? 59.053  92.406  138.396 1.00 86.73  ? 223 VAL A CA    1 
ATOM   654  C C     . VAL A 1 249 ? 60.369  93.114  138.146 1.00 78.82  ? 223 VAL A C     1 
ATOM   655  O O     . VAL A 1 249 ? 60.904  93.078  137.044 1.00 100.01 ? 223 VAL A O     1 
ATOM   656  C CB    . VAL A 1 249 ? 57.891  93.369  138.176 1.00 92.84  ? 223 VAL A CB    1 
ATOM   657  C CG1   . VAL A 1 249 ? 58.102  94.224  136.946 1.00 117.20 ? 223 VAL A CG1   1 
ATOM   658  C CG2   . VAL A 1 249 ? 56.620  92.560  138.045 1.00 144.31 ? 223 VAL A CG2   1 
ATOM   659  N N     . THR A 1 250 ? 60.867  93.792  139.161 1.00 70.07  ? 224 THR A N     1 
ATOM   660  C CA    . THR A 1 250 ? 61.917  94.717  138.867 1.00 69.62  ? 224 THR A CA    1 
ATOM   661  C C     . THR A 1 250 ? 63.111  93.905  138.484 1.00 72.91  ? 224 THR A C     1 
ATOM   662  O O     . THR A 1 250 ? 63.749  94.312  137.511 1.00 72.44  ? 224 THR A O     1 
ATOM   663  C CB    . THR A 1 250 ? 62.263  95.653  140.000 1.00 85.84  ? 224 THR A CB    1 
ATOM   664  O OG1   . THR A 1 250 ? 61.598  96.888  139.702 1.00 78.15  ? 224 THR A OG1   1 
ATOM   665  C CG2   . THR A 1 250 ? 63.740  95.959  139.944 1.00 100.40 ? 224 THR A CG2   1 
ATOM   666  N N     . GLU A 1 251 ? 63.313  92.773  139.200 1.00 78.60  ? 225 GLU A N     1 
ATOM   667  C CA    . GLU A 1 251 ? 64.349  91.763  138.917 1.00 82.82  ? 225 GLU A CA    1 
ATOM   668  C C     . GLU A 1 251 ? 64.343  91.225  137.469 1.00 73.26  ? 225 GLU A C     1 
ATOM   669  O O     . GLU A 1 251 ? 65.367  91.272  136.779 1.00 57.46  ? 225 GLU A O     1 
ATOM   670  C CB    . GLU A 1 251 ? 64.168  90.581  139.850 1.00 78.15  ? 225 GLU A CB    1 
ATOM   671  C CG    . GLU A 1 251 ? 65.098  89.406  139.589 1.00 99.25  ? 225 GLU A CG    1 
ATOM   672  C CD    . GLU A 1 251 ? 66.099  89.184  140.713 1.00 142.19 ? 225 GLU A CD    1 
ATOM   673  O OE1   . GLU A 1 251 ? 65.634  89.036  141.880 1.00 160.10 ? 225 GLU A OE1   1 
ATOM   674  O OE2   . GLU A 1 251 ? 67.331  89.128  140.436 1.00 164.30 ? 225 GLU A OE2   1 
ATOM   675  N N     . LEU A 1 252 ? 63.189  90.772  136.970 1.00 75.42  ? 226 LEU A N     1 
ATOM   676  C CA    . LEU A 1 252 ? 63.031  90.470  135.550 1.00 89.25  ? 226 LEU A CA    1 
ATOM   677  C C     . LEU A 1 252 ? 63.575  91.582  134.660 1.00 81.05  ? 226 LEU A C     1 
ATOM   678  O O     . LEU A 1 252 ? 64.408  91.305  133.807 1.00 90.84  ? 226 LEU A O     1 
ATOM   679  C CB    . LEU A 1 252 ? 61.565  90.205  135.226 1.00 104.03 ? 226 LEU A CB    1 
ATOM   680  C CG    . LEU A 1 252 ? 61.188  88.727  135.262 1.00 127.78 ? 226 LEU A CG    1 
ATOM   681  C CD1   . LEU A 1 252 ? 61.512  88.118  133.915 1.00 163.77 ? 226 LEU A CD1   1 
ATOM   682  C CD2   . LEU A 1 252 ? 61.927  87.993  136.390 1.00 136.50 ? 226 LEU A CD2   1 
ATOM   683  N N     . THR A 1 253 ? 63.058  92.801  134.835 1.00 74.95  ? 227 THR A N     1 
ATOM   684  C CA    . THR A 1 253 ? 63.502  93.958  134.080 1.00 79.16  ? 227 THR A CA    1 
ATOM   685  C C     . THR A 1 253 ? 65.010  94.099  134.153 1.00 79.69  ? 227 THR A C     1 
ATOM   686  O O     . THR A 1 253 ? 65.682  94.238  133.130 1.00 89.59  ? 227 THR A O     1 
ATOM   687  C CB    . THR A 1 253 ? 62.891  95.216  134.671 1.00 88.95  ? 227 THR A CB    1 
ATOM   688  O OG1   . THR A 1 253 ? 61.572  94.708  134.843 1.00 121.73 ? 227 THR A OG1   1 
ATOM   689  C CG2   . THR A 1 253 ? 63.050  96.426  133.758 1.00 83.04  ? 227 THR A CG2   1 
ATOM   690  N N     . GLN A 1 254 ? 65.520  94.103  135.379 1.00 62.73  ? 228 GLN A N     1 
ATOM   691  C CA    . GLN A 1 254 ? 66.928  94.365  135.591 1.00 71.78  ? 228 GLN A CA    1 
ATOM   692  C C     . GLN A 1 254 ? 67.769  93.243  134.975 1.00 77.24  ? 228 GLN A C     1 
ATOM   693  O O     . GLN A 1 254 ? 68.887  93.482  134.506 1.00 62.01  ? 228 GLN A O     1 
ATOM   694  C CB    . GLN A 1 254 ? 67.141  94.550  137.086 1.00 75.85  ? 228 GLN A CB    1 
ATOM   695  C CG    . GLN A 1 254 ? 68.491  95.125  137.471 1.00 88.94  ? 228 GLN A CG    1 
ATOM   696  C CD    . GLN A 1 254 ? 68.842  94.772  138.902 1.00 114.31 ? 228 GLN A CD    1 
ATOM   697  O OE1   . GLN A 1 254 ? 69.680  93.895  139.174 1.00 83.92  ? 228 GLN A OE1   1 
ATOM   698  N NE2   . GLN A 1 254 ? 68.168  95.444  139.829 1.00 111.59 ? 228 GLN A NE2   1 
ATOM   699  N N     . ASN A 1 255 ? 67.223  92.025  134.890 1.00 68.78  ? 229 ASN A N     1 
ATOM   700  C CA    . ASN A 1 255 ? 67.937  90.987  134.160 1.00 69.37  ? 229 ASN A CA    1 
ATOM   701  C C     . ASN A 1 255 ? 68.012  91.277  132.663 1.00 71.62  ? 229 ASN A C     1 
ATOM   702  O O     . ASN A 1 255 ? 69.060  91.144  132.032 1.00 70.18  ? 229 ASN A O     1 
ATOM   703  C CB    . ASN A 1 255 ? 67.429  89.606  134.517 1.00 71.30  ? 229 ASN A CB    1 
ATOM   704  C CG    . ASN A 1 255 ? 67.957  89.311  135.900 1.00 100.47 ? 229 ASN A CG    1 
ATOM   705  O OD1   . ASN A 1 255 ? 68.662  90.165  136.474 1.00 76.30  ? 229 ASN A OD1   1 
ATOM   706  N ND2   . ASN A 1 255 ? 67.639  88.138  136.442 1.00 126.95 ? 229 ASN A ND2   1 
ATOM   707  N N     . ALA A 1 256 ? 66.915  91.738  132.099 1.00 76.57  ? 230 ALA A N     1 
ATOM   708  C CA    . ALA A 1 256 ? 66.882  91.948  130.672 1.00 77.43  ? 230 ALA A CA    1 
ATOM   709  C C     . ALA A 1 256 ? 67.861  93.035  130.289 1.00 81.03  ? 230 ALA A C     1 
ATOM   710  O O     . ALA A 1 256 ? 68.480  92.993  129.237 1.00 94.97  ? 230 ALA A O     1 
ATOM   711  C CB    . ALA A 1 256 ? 65.505  92.364  130.299 1.00 112.47 ? 230 ALA A CB    1 
ATOM   712  N N     . LEU A 1 257 ? 67.964  94.026  131.157 1.00 76.52  ? 231 LEU A N     1 
ATOM   713  C CA    . LEU A 1 257 ? 68.676  95.236  130.827 1.00 61.02  ? 231 LEU A CA    1 
ATOM   714  C C     . LEU A 1 257 ? 70.154  95.049  131.051 1.00 50.77  ? 231 LEU A C     1 
ATOM   715  O O     . LEU A 1 257 ? 70.933  95.758  130.467 1.00 65.92  ? 231 LEU A O     1 
ATOM   716  C CB    . LEU A 1 257 ? 68.115  96.300  131.762 1.00 75.20  ? 231 LEU A CB    1 
ATOM   717  C CG    . LEU A 1 257 ? 68.940  97.573  131.964 1.00 67.57  ? 231 LEU A CG    1 
ATOM   718  C CD1   . LEU A 1 257 ? 69.271  98.173  130.675 1.00 64.59  ? 231 LEU A CD1   1 
ATOM   719  C CD2   . LEU A 1 257 ? 68.166  98.603  132.755 1.00 65.24  ? 231 LEU A CD2   1 
ATOM   720  N N     . ILE A 1 258 ? 70.556  94.172  131.952 1.00 58.21  ? 232 ILE A N     1 
ATOM   721  C CA    . ILE A 1 258 ? 71.973  94.090  132.256 1.00 59.28  ? 232 ILE A CA    1 
ATOM   722  C C     . ILE A 1 258 ? 72.605  93.026  131.392 1.00 74.83  ? 232 ILE A C     1 
ATOM   723  O O     . ILE A 1 258 ? 73.738  93.262  130.987 1.00 83.53  ? 232 ILE A O     1 
ATOM   724  C CB    . ILE A 1 258 ? 72.181  93.725  133.712 1.00 53.88  ? 232 ILE A CB    1 
ATOM   725  C CG1   . ILE A 1 258 ? 72.091  94.887  134.561 1.00 52.94  ? 232 ILE A CG1   1 
ATOM   726  C CG2   . ILE A 1 258 ? 73.516  93.067  133.908 1.00 70.81  ? 232 ILE A CG2   1 
ATOM   727  C CD1   . ILE A 1 258 ? 72.076  94.473  136.008 1.00 57.99  ? 232 ILE A CD1   1 
ATOM   728  N N     . ASN A 1 259 ? 71.877  91.894  131.162 1.00 88.30  ? 233 ASN A N     1 
ATOM   729  C CA    . ASN A 1 259 ? 72.411  90.679  130.530 1.00 88.31  ? 233 ASN A CA    1 
ATOM   730  C C     . ASN A 1 259 ? 72.113  90.586  129.032 1.00 82.17  ? 233 ASN A C     1 
ATOM   731  O O     . ASN A 1 259 ? 72.852  89.914  128.311 1.00 90.88  ? 233 ASN A O     1 
ATOM   732  C CB    . ASN A 1 259 ? 71.931  89.382  131.160 1.00 79.08  ? 233 ASN A CB    1 
ATOM   733  C CG    . ASN A 1 259 ? 72.155  89.440  132.638 1.00 98.08  ? 233 ASN A CG    1 
ATOM   734  O OD1   . ASN A 1 259 ? 72.724  90.427  133.124 1.00 75.34  ? 233 ASN A OD1   1 
ATOM   735  N ND2   . ASN A 1 259 ? 71.682  88.429  133.358 1.00 122.28 ? 233 ASN A ND2   1 
ATOM   736  N N     . ASP A 1 260 ? 71.081  91.258  128.533 1.00 70.42  ? 234 ASP A N     1 
ATOM   737  C CA    . ASP A 1 260 ? 70.999  91.437  127.091 1.00 79.44  ? 234 ASP A CA    1 
ATOM   738  C C     . ASP A 1 260 ? 71.524  92.826  126.748 1.00 73.48  ? 234 ASP A C     1 
ATOM   739  O O     . ASP A 1 260 ? 72.573  92.946  126.132 1.00 87.41  ? 234 ASP A O     1 
ATOM   740  C CB    . ASP A 1 260 ? 69.617  91.135  126.536 1.00 108.67 ? 234 ASP A CB    1 
ATOM   741  C CG    . ASP A 1 260 ? 69.171  89.682  126.679 1.00 159.30 ? 234 ASP A CG    1 
ATOM   742  O OD1   . ASP A 1 260 ? 69.558  89.049  127.690 1.00 182.50 ? 234 ASP A OD1   1 
ATOM   743  O OD2   . ASP A 1 260 ? 68.410  89.194  125.801 1.00 180.99 ? 234 ASP A OD2   1 
ATOM   744  N N     . GLU A 1 261 ? 70.869  93.876  127.247 1.00 73.81  ? 235 GLU A N     1 
ATOM   745  C CA    . GLU A 1 261 ? 70.932  95.153  126.562 1.00 82.61  ? 235 GLU A CA    1 
ATOM   746  C C     . GLU A 1 261 ? 72.331  95.734  126.583 1.00 71.07  ? 235 GLU A C     1 
ATOM   747  O O     . GLU A 1 261 ? 72.842  96.167  125.539 1.00 65.93  ? 235 GLU A O     1 
ATOM   748  C CB    . GLU A 1 261 ? 70.059  96.281  127.106 1.00 91.36  ? 235 GLU A CB    1 
ATOM   749  C CG    . GLU A 1 261 ? 68.729  96.361  126.370 1.00 120.38 ? 235 GLU A CG    1 
ATOM   750  C CD    . GLU A 1 261 ? 68.858  95.968  124.917 1.00 145.19 ? 235 GLU A CD    1 
ATOM   751  O OE1   . GLU A 1 261 ? 69.337  96.805  124.119 1.00 174.19 ? 235 GLU A OE1   1 
ATOM   752  O OE2   . GLU A 1 261 ? 68.547  94.785  124.622 1.00 154.04 ? 235 GLU A OE2   1 
ATOM   753  N N     . LEU A 1 262 ? 72.872  95.788  127.795 1.00 53.52  ? 236 LEU A N     1 
ATOM   754  C CA    . LEU A 1 262 ? 74.219  96.272  127.994 1.00 56.46  ? 236 LEU A CA    1 
ATOM   755  C C     . LEU A 1 262 ? 75.140  95.301  127.307 1.00 55.55  ? 236 LEU A C     1 
ATOM   756  O O     . LEU A 1 262 ? 76.007  95.689  126.510 1.00 55.54  ? 236 LEU A O     1 
ATOM   757  C CB    . LEU A 1 262 ? 74.672  96.346  129.436 1.00 64.97  ? 236 LEU A CB    1 
ATOM   758  C CG    . LEU A 1 262 ? 75.469  97.599  129.734 1.00 60.32  ? 236 LEU A CG    1 
ATOM   759  C CD1   . LEU A 1 262 ? 75.676  97.474  131.164 1.00 75.25  ? 236 LEU A CD1   1 
ATOM   760  C CD2   . LEU A 1 262 ? 76.756  97.595  129.051 1.00 78.98  ? 236 LEU A CD2   1 
ATOM   761  N N     . VAL A 1 263 ? 74.937  94.032  127.615 1.00 49.18  ? 237 VAL A N     1 
ATOM   762  C CA    . VAL A 1 263 ? 75.849  93.116  127.001 1.00 61.22  ? 237 VAL A CA    1 
ATOM   763  C C     . VAL A 1 263 ? 75.971  93.379  125.493 1.00 75.50  ? 237 VAL A C     1 
ATOM   764  O O     . VAL A 1 263 ? 77.091  93.395  124.939 1.00 67.85  ? 237 VAL A O     1 
ATOM   765  C CB    . VAL A 1 263 ? 75.472  91.698  127.330 1.00 56.30  ? 237 VAL A CB    1 
ATOM   766  C CG1   . VAL A 1 263 ? 76.326  90.788  126.497 1.00 64.85  ? 237 VAL A CG1   1 
ATOM   767  C CG2   . VAL A 1 263 ? 75.745  91.507  128.808 1.00 86.46  ? 237 VAL A CG2   1 
ATOM   768  N N     . GLU A 1 264 ? 74.841  93.650  124.840 1.00 56.68  ? 238 GLU A N     1 
ATOM   769  C CA    . GLU A 1 264 ? 74.946  93.681  123.414 1.00 64.03  ? 238 GLU A CA    1 
ATOM   770  C C     . GLU A 1 264 ? 75.740  94.903  123.024 1.00 61.44  ? 238 GLU A C     1 
ATOM   771  O O     . GLU A 1 264 ? 76.583  94.825  122.138 1.00 83.50  ? 238 GLU A O     1 
ATOM   772  C CB    . GLU A 1 264 ? 73.671  93.357  122.662 1.00 96.01  ? 238 GLU A CB    1 
ATOM   773  C CG    . GLU A 1 264 ? 73.452  91.842  122.725 1.00 143.05 ? 238 GLU A CG    1 
ATOM   774  C CD    . GLU A 1 264 ? 73.312  91.136  121.388 1.00 199.63 ? 238 GLU A CD    1 
ATOM   775  O OE1   . GLU A 1 264 ? 74.238  91.285  120.555 1.00 220.75 ? 238 GLU A OE1   1 
ATOM   776  O OE2   . GLU A 1 264 ? 72.293  90.433  121.186 1.00 237.15 ? 238 GLU A OE2   1 
ATOM   777  N N     . TRP A 1 265 ? 75.584  95.981  123.764 1.00 63.86  ? 239 TRP A N     1 
ATOM   778  C CA    . TRP A 1 265 ? 76.227  97.225  123.373 1.00 53.50  ? 239 TRP A CA    1 
ATOM   779  C C     . TRP A 1 265 ? 77.705  97.022  123.421 1.00 50.53  ? 239 TRP A C     1 
ATOM   780  O O     . TRP A 1 265 ? 78.398  97.572  122.565 1.00 49.20  ? 239 TRP A O     1 
ATOM   781  C CB    . TRP A 1 265 ? 75.867  98.327  124.348 1.00 59.04  ? 239 TRP A CB    1 
ATOM   782  C CG    . TRP A 1 265 ? 76.374  99.683  124.038 1.00 51.47  ? 239 TRP A CG    1 
ATOM   783  C CD1   . TRP A 1 265 ? 75.770  100.665 123.332 1.00 64.94  ? 239 TRP A CD1   1 
ATOM   784  C CD2   . TRP A 1 265 ? 77.580  100.235 124.521 1.00 68.43  ? 239 TRP A CD2   1 
ATOM   785  N NE1   . TRP A 1 265 ? 76.521  101.804 123.316 1.00 61.19  ? 239 TRP A NE1   1 
ATOM   786  C CE2   . TRP A 1 265 ? 77.655  101.551 124.019 1.00 69.59  ? 239 TRP A CE2   1 
ATOM   787  C CE3   . TRP A 1 265 ? 78.609  99.730  125.295 1.00 71.99  ? 239 TRP A CE3   1 
ATOM   788  C CZ2   . TRP A 1 265 ? 78.744  102.369 124.244 1.00 75.12  ? 239 TRP A CZ2   1 
ATOM   789  C CZ3   . TRP A 1 265 ? 79.703  100.546 125.488 1.00 88.66  ? 239 TRP A CZ3   1 
ATOM   790  C CH2   . TRP A 1 265 ? 79.788  101.827 124.940 1.00 73.64  ? 239 TRP A CH2   1 
ATOM   791  N N     . LYS A 1 266 ? 78.124  96.199  124.396 1.00 50.15  ? 240 LYS A N     1 
ATOM   792  C CA    . LYS A 1 266 ? 79.540  96.118  124.629 1.00 50.97  ? 240 LYS A CA    1 
ATOM   793  C C     . LYS A 1 266 ? 80.153  95.351  123.492 1.00 49.27  ? 240 LYS A C     1 
ATOM   794  O O     . LYS A 1 266 ? 81.153  95.826  122.965 1.00 81.83  ? 240 LYS A O     1 
ATOM   795  C CB    . LYS A 1 266 ? 79.995  95.591  125.965 1.00 55.51  ? 240 LYS A CB    1 
ATOM   796  C CG    . LYS A 1 266 ? 79.506  96.350  127.122 1.00 54.99  ? 240 LYS A CG    1 
ATOM   797  C CD    . LYS A 1 266 ? 79.888  95.641  128.427 1.00 67.46  ? 240 LYS A CD    1 
ATOM   798  C CE    . LYS A 1 266 ? 80.757  96.452  129.354 1.00 90.40  ? 240 LYS A CE    1 
ATOM   799  N NZ    . LYS A 1 266 ? 80.245  96.384  130.731 1.00 93.64  ? 240 LYS A NZ    1 
ATOM   800  N N     . ARG A 1 267 ? 79.509  94.286  123.026 1.00 61.10  ? 241 ARG A N     1 
ATOM   801  C CA    . ARG A 1 267 ? 80.023  93.651  121.813 1.00 69.88  ? 241 ARG A CA    1 
ATOM   802  C C     . ARG A 1 267 ? 80.024  94.649  120.658 1.00 48.79  ? 241 ARG A C     1 
ATOM   803  O O     . ARG A 1 267 ? 81.035  94.803  119.965 1.00 32.94  ? 241 ARG A O     1 
ATOM   804  C CB    . ARG A 1 267 ? 79.342  92.331  121.459 1.00 81.07  ? 241 ARG A CB    1 
ATOM   805  C CG    . ARG A 1 267 ? 79.635  91.910  120.037 1.00 100.83 ? 241 ARG A CG    1 
ATOM   806  C CD    . ARG A 1 267 ? 81.114  91.806  119.710 1.00 116.77 ? 241 ARG A CD    1 
ATOM   807  N NE    . ARG A 1 267 ? 81.636  90.434  119.721 1.00 152.01 ? 241 ARG A NE    1 
ATOM   808  C CZ    . ARG A 1 267 ? 82.895  90.099  119.422 1.00 158.52 ? 241 ARG A CZ    1 
ATOM   809  N NH1   . ARG A 1 267 ? 83.781  91.034  119.109 1.00 149.45 ? 241 ARG A NH1   1 
ATOM   810  N NH2   . ARG A 1 267 ? 83.271  88.828  119.452 1.00 159.09 ? 241 ARG A NH2   1 
ATOM   811  N N     . ARG A 1 268 ? 78.954  95.430  120.567 1.00 49.55  ? 242 ARG A N     1 
ATOM   812  C CA    . ARG A 1 268 ? 78.863  96.343  119.446 1.00 67.67  ? 242 ARG A CA    1 
ATOM   813  C C     . ARG A 1 268 ? 80.077  97.238  119.450 1.00 50.90  ? 242 ARG A C     1 
ATOM   814  O O     . ARG A 1 268 ? 80.522  97.604  118.346 1.00 55.93  ? 242 ARG A O     1 
ATOM   815  C CB    . ARG A 1 268 ? 77.580  97.144  119.180 1.00 85.67  ? 242 ARG A CB    1 
ATOM   816  C CG    . ARG A 1 268 ? 76.568  96.128  118.651 1.00 116.12 ? 242 ARG A CG    1 
ATOM   817  C CD    . ARG A 1 268 ? 75.266  96.641  118.016 1.00 139.18 ? 242 ARG A CD    1 
ATOM   818  N NE    . ARG A 1 268 ? 74.270  97.191  118.943 1.00 127.44 ? 242 ARG A NE    1 
ATOM   819  C CZ    . ARG A 1 268 ? 74.382  98.372  119.532 1.00 136.78 ? 242 ARG A CZ    1 
ATOM   820  N NH1   . ARG A 1 268 ? 75.307  99.232  119.127 1.00 151.13 ? 242 ARG A NH1   1 
ATOM   821  N NH2   . ARG A 1 268 ? 73.561  98.698  120.518 1.00 139.47 ? 242 ARG A NH2   1 
ATOM   822  N N     . GLN A 1 269 ? 80.633  97.479  120.650 1.00 43.89  ? 243 GLN A N     1 
ATOM   823  C CA    . GLN A 1 269 ? 81.741  98.430  120.791 1.00 47.89  ? 243 GLN A CA    1 
ATOM   824  C C     . GLN A 1 269 ? 83.092  97.807  120.466 1.00 45.85  ? 243 GLN A C     1 
ATOM   825  O O     . GLN A 1 269 ? 83.880  98.458  119.748 1.00 32.99  ? 243 GLN A O     1 
ATOM   826  C CB    . GLN A 1 269 ? 81.843  99.237  122.073 1.00 44.96  ? 243 GLN A CB    1 
ATOM   827  C CG    . GLN A 1 269 ? 83.250  99.283  122.652 1.00 56.56  ? 243 GLN A CG    1 
ATOM   828  C CD    . GLN A 1 269 ? 83.270  99.657  124.129 1.00 70.49  ? 243 GLN A CD    1 
ATOM   829  O OE1   . GLN A 1 269 ? 83.047  98.828  125.060 1.00 56.53  ? 243 GLN A OE1   1 
ATOM   830  N NE2   . GLN A 1 269 ? 83.507  100.956 124.310 1.00 58.81  ? 243 GLN A NE2   1 
ATOM   831  N N     . GLN A 1 270 ? 83.308  96.591  121.009 1.00 42.57  ? 244 GLN A N     1 
ATOM   832  C CA    . GLN A 1 270 ? 84.337  95.725  120.497 1.00 43.57  ? 244 GLN A CA    1 
ATOM   833  C C     . GLN A 1 270 ? 84.449  95.809  118.986 1.00 53.84  ? 244 GLN A C     1 
ATOM   834  O O     . GLN A 1 270 ? 85.542  95.582  118.460 1.00 70.89  ? 244 GLN A O     1 
ATOM   835  C CB    . GLN A 1 270 ? 84.159  94.231  120.535 1.00 40.43  ? 244 GLN A CB    1 
ATOM   836  C CG    . GLN A 1 270 ? 84.665  93.800  121.871 1.00 53.09  ? 244 GLN A CG    1 
ATOM   837  C CD    . GLN A 1 270 ? 84.905  92.314  121.957 1.00 59.88  ? 244 GLN A CD    1 
ATOM   838  O OE1   . GLN A 1 270 ? 85.972  91.808  121.602 1.00 53.79  ? 244 GLN A OE1   1 
ATOM   839  N NE2   . GLN A 1 270 ? 83.996  91.651  122.653 1.00 78.03  ? 244 GLN A NE2   1 
ATOM   840  N N     . SER A 1 271 ? 83.355  96.031  118.274 1.00 47.17  ? 245 SER A N     1 
ATOM   841  C CA    . SER A 1 271 ? 83.551  95.827  116.866 1.00 54.82  ? 245 SER A CA    1 
ATOM   842  C C     . SER A 1 271 ? 83.873  97.170  116.267 1.00 57.66  ? 245 SER A C     1 
ATOM   843  O O     . SER A 1 271 ? 84.808  97.266  115.462 1.00 59.98  ? 245 SER A O     1 
ATOM   844  C CB    . SER A 1 271 ? 82.451  95.059  116.245 1.00 61.07  ? 245 SER A CB    1 
ATOM   845  O OG    . SER A 1 271 ? 82.931  93.711  116.182 1.00 60.70  ? 245 SER A OG    1 
ATOM   846  N N     . ALA A 1 272 ? 83.232  98.196  116.811 1.00 50.78  ? 246 ALA A N     1 
ATOM   847  C CA    . ALA A 1 272 ? 83.642  99.532  116.437 1.00 69.31  ? 246 ALA A CA    1 
ATOM   848  C C     . ALA A 1 272 ? 85.159  99.737  116.469 1.00 68.02  ? 246 ALA A C     1 
ATOM   849  O O     . ALA A 1 272 ? 85.640  100.593 115.753 1.00 80.63  ? 246 ALA A O     1 
ATOM   850  C CB    . ALA A 1 272 ? 83.039  100.543 117.364 1.00 91.79  ? 246 ALA A CB    1 
ATOM   851  N N     . CYS A 1 273 ? 85.885  99.076  117.372 1.00 71.50  ? 247 CYS A N     1 
ATOM   852  C CA    . CYS A 1 273 ? 87.300  99.344  117.597 1.00 65.64  ? 247 CYS A CA    1 
ATOM   853  C C     . CYS A 1 273 ? 88.153  98.810  116.468 1.00 57.81  ? 247 CYS A C     1 
ATOM   854  O O     . CYS A 1 273 ? 89.013  99.502  115.886 1.00 52.31  ? 247 CYS A O     1 
ATOM   855  C CB    . CYS A 1 273 ? 87.762  98.714  118.893 1.00 67.47  ? 247 CYS A CB    1 
ATOM   856  S SG    . CYS A 1 273 ? 87.003  99.663  120.236 1.00 102.43 ? 247 CYS A SG    1 
ATOM   857  N N     . ILE A 1 274 ? 87.823  97.624  116.037 1.00 47.89  ? 248 ILE A N     1 
ATOM   858  C CA    . ILE A 1 274 ? 88.501  97.257  114.829 1.00 51.35  ? 248 ILE A CA    1 
ATOM   859  C C     . ILE A 1 274 ? 87.782  97.728  113.589 1.00 50.75  ? 248 ILE A C     1 
ATOM   860  O O     . ILE A 1 274 ? 87.999  97.112  112.566 1.00 60.60  ? 248 ILE A O     1 
ATOM   861  C CB    . ILE A 1 274 ? 88.697  95.766  114.810 1.00 51.71  ? 248 ILE A CB    1 
ATOM   862  C CG1   . ILE A 1 274 ? 87.401  95.043  114.594 1.00 60.14  ? 248 ILE A CG1   1 
ATOM   863  C CG2   . ILE A 1 274 ? 89.353  95.428  116.131 1.00 64.33  ? 248 ILE A CG2   1 
ATOM   864  C CD1   . ILE A 1 274 ? 87.552  93.558  114.885 1.00 74.68  ? 248 ILE A CD1   1 
ATOM   865  N N     . GLY A 1 275 ? 87.058  98.846  113.619 1.00 54.25  ? 249 GLY A N     1 
ATOM   866  C CA    . GLY A 1 275 ? 86.376  99.316  112.415 1.00 59.73  ? 249 GLY A CA    1 
ATOM   867  C C     . GLY A 1 275 ? 85.184  98.411  112.115 1.00 86.68  ? 249 GLY A C     1 
ATOM   868  O O     . GLY A 1 275 ? 85.124  97.247  112.522 1.00 95.39  ? 249 GLY A O     1 
ATOM   869  N N     . GLY A 1 276 ? 84.171  98.974  111.490 1.00 100.98 ? 250 GLY A N     1 
ATOM   870  C CA    . GLY A 1 276 ? 82.865  98.369  111.621 1.00 94.98  ? 250 GLY A CA    1 
ATOM   871  C C     . GLY A 1 276 ? 81.820  99.413  112.010 1.00 105.80 ? 250 GLY A C     1 
ATOM   872  O O     . GLY A 1 276 ? 82.113  100.540 112.443 1.00 92.53  ? 250 GLY A O     1 
ATOM   873  N N     . PRO A 1 277 ? 80.558  98.971  111.947 1.00 92.04  ? 251 PRO A N     1 
ATOM   874  C CA    . PRO A 1 277 ? 79.408  99.856  112.037 1.00 86.08  ? 251 PRO A CA    1 
ATOM   875  C C     . PRO A 1 277 ? 79.513  100.628 113.341 1.00 85.76  ? 251 PRO A C     1 
ATOM   876  O O     . PRO A 1 277 ? 79.650  100.026 114.403 1.00 94.61  ? 251 PRO A O     1 
ATOM   877  C CB    . PRO A 1 277 ? 78.203  98.924  112.095 1.00 117.37 ? 251 PRO A CB    1 
ATOM   878  C CG    . PRO A 1 277 ? 78.744  97.496  112.048 1.00 114.01 ? 251 PRO A CG    1 
ATOM   879  C CD    . PRO A 1 277 ? 80.236  97.544  112.024 1.00 99.05  ? 251 PRO A CD    1 
ATOM   880  N N     . PRO A 1 278 ? 79.424  101.965 113.320 1.00 95.04  ? 252 PRO A N     1 
ATOM   881  C CA    . PRO A 1 278 ? 79.592  102.758 114.540 1.00 93.39  ? 252 PRO A CA    1 
ATOM   882  C C     . PRO A 1 278 ? 78.510  102.480 115.574 1.00 101.36 ? 252 PRO A C     1 
ATOM   883  O O     . PRO A 1 278 ? 77.368  102.164 115.232 1.00 120.52 ? 252 PRO A O     1 
ATOM   884  C CB    . PRO A 1 278 ? 79.599  104.204 114.076 1.00 109.38 ? 252 PRO A CB    1 
ATOM   885  C CG    . PRO A 1 278 ? 78.910  104.138 112.715 1.00 143.73 ? 252 PRO A CG    1 
ATOM   886  C CD    . PRO A 1 278 ? 79.192  102.766 112.120 1.00 123.58 ? 252 PRO A CD    1 
ATOM   887  N N     . ASN A 1 279 ? 78.919  102.579 116.841 1.00 105.20 ? 253 ASN A N     1 
ATOM   888  C CA    . ASN A 1 279 ? 78.088  102.179 117.957 1.00 111.30 ? 253 ASN A CA    1 
ATOM   889  C C     . ASN A 1 279 ? 77.180  103.358 118.267 1.00 119.67 ? 253 ASN A C     1 
ATOM   890  O O     . ASN A 1 279 ? 77.572  104.513 118.086 1.00 112.75 ? 253 ASN A O     1 
ATOM   891  C CB    . ASN A 1 279 ? 78.918  101.801 119.182 1.00 128.25 ? 253 ASN A CB    1 
ATOM   892  C CG    . ASN A 1 279 ? 78.137  101.021 120.217 1.00 127.79 ? 253 ASN A CG    1 
ATOM   893  O OD1   . ASN A 1 279 ? 76.964  101.320 120.462 1.00 127.38 ? 253 ASN A OD1   1 
ATOM   894  N ND2   . ASN A 1 279 ? 78.753  100.029 120.844 1.00 119.27 ? 253 ASN A ND2   1 
ATOM   895  N N     . ALA A 1 280 ? 75.988  103.027 118.767 1.00 106.77 ? 254 ALA A N     1 
ATOM   896  C CA    . ALA A 1 280 ? 75.007  104.004 119.195 1.00 107.32 ? 254 ALA A CA    1 
ATOM   897  C C     . ALA A 1 280 ? 75.452  104.686 120.493 1.00 103.21 ? 254 ALA A C     1 
ATOM   898  O O     . ALA A 1 280 ? 76.323  104.177 121.189 1.00 105.97 ? 254 ALA A O     1 
ATOM   899  C CB    . ALA A 1 280 ? 73.704  103.260 119.338 1.00 106.69 ? 254 ALA A CB    1 
ATOM   900  N N     . CYS A 1 281 ? 74.819  105.812 120.841 1.00 113.97 ? 255 CYS A N     1 
ATOM   901  C CA    . CYS A 1 281 ? 75.058  106.474 122.120 1.00 128.51 ? 255 CYS A CA    1 
ATOM   902  C C     . CYS A 1 281 ? 74.645  105.614 123.329 1.00 104.79 ? 255 CYS A C     1 
ATOM   903  O O     . CYS A 1 281 ? 73.873  104.664 123.211 1.00 111.69 ? 255 CYS A O     1 
ATOM   904  C CB    . CYS A 1 281 ? 74.318  107.807 122.171 1.00 137.72 ? 255 CYS A CB    1 
ATOM   905  S SG    . CYS A 1 281 ? 75.085  108.992 123.307 1.00 209.45 ? 255 CYS A SG    1 
ATOM   906  N N     . LEU A 1 282 ? 75.147  105.978 124.519 1.00 81.63  ? 256 LEU A N     1 
ATOM   907  C CA    . LEU A 1 282 ? 74.739  105.338 125.761 1.00 82.83  ? 256 LEU A CA    1 
ATOM   908  C C     . LEU A 1 282 ? 73.530  106.021 126.398 1.00 104.55 ? 256 LEU A C     1 
ATOM   909  O O     . LEU A 1 282 ? 73.210  105.689 127.537 1.00 87.66  ? 256 LEU A O     1 
ATOM   910  C CB    . LEU A 1 282 ? 75.889  105.351 126.758 1.00 72.39  ? 256 LEU A CB    1 
ATOM   911  C CG    . LEU A 1 282 ? 77.021  104.357 126.475 1.00 87.69  ? 256 LEU A CG    1 
ATOM   912  C CD1   . LEU A 1 282 ? 78.025  104.705 127.533 1.00 85.27  ? 256 LEU A CD1   1 
ATOM   913  C CD2   . LEU A 1 282 ? 76.765  102.833 126.475 1.00 73.14  ? 256 LEU A CD2   1 
ATOM   914  N N     . ASP A 1 283 ? 72.864  106.949 125.684 1.00 119.71 ? 257 ASP A N     1 
ATOM   915  C CA    . ASP A 1 283 ? 71.732  107.683 126.235 1.00 108.35 ? 257 ASP A CA    1 
ATOM   916  C C     . ASP A 1 283 ? 70.572  106.740 126.537 1.00 109.15 ? 257 ASP A C     1 
ATOM   917  O O     . ASP A 1 283 ? 70.156  106.612 127.692 1.00 123.24 ? 257 ASP A O     1 
ATOM   918  C CB    . ASP A 1 283 ? 71.274  108.822 125.345 1.00 108.54 ? 257 ASP A CB    1 
ATOM   919  C CG    . ASP A 1 283 ? 72.279  109.960 125.235 1.00 147.68 ? 257 ASP A CG    1 
ATOM   920  O OD1   . ASP A 1 283 ? 72.911  110.291 126.265 1.00 143.56 ? 257 ASP A OD1   1 
ATOM   921  O OD2   . ASP A 1 283 ? 72.408  110.524 124.124 1.00 183.77 ? 257 ASP A OD2   1 
ATOM   922  N N     . GLN A 1 284 ? 70.044  106.088 125.505 1.00 89.11  ? 258 GLN A N     1 
ATOM   923  C CA    . GLN A 1 284 ? 68.901  105.223 125.724 1.00 98.03  ? 258 GLN A CA    1 
ATOM   924  C C     . GLN A 1 284 ? 69.162  104.350 126.946 1.00 86.68  ? 258 GLN A C     1 
ATOM   925  O O     . GLN A 1 284 ? 68.314  104.252 127.832 1.00 115.47 ? 258 GLN A O     1 
ATOM   926  C CB    . GLN A 1 284 ? 68.610  104.354 124.503 1.00 131.28 ? 258 GLN A CB    1 
ATOM   927  C CG    . GLN A 1 284 ? 67.257  103.652 124.528 1.00 135.73 ? 258 GLN A CG    1 
ATOM   928  C CD    . GLN A 1 284 ? 67.029  102.851 123.265 1.00 162.52 ? 258 GLN A CD    1 
ATOM   929  O OE1   . GLN A 1 284 ? 67.950  102.208 122.739 1.00 142.92 ? 258 GLN A OE1   1 
ATOM   930  N NE2   . GLN A 1 284 ? 65.804  102.908 122.751 1.00 185.80 ? 258 GLN A NE2   1 
ATOM   931  N N     . LEU A 1 285 ? 70.328  103.705 126.979 1.00 72.72  ? 259 LEU A N     1 
ATOM   932  C CA    . LEU A 1 285 ? 70.616  102.804 128.074 1.00 62.49  ? 259 LEU A CA    1 
ATOM   933  C C     . LEU A 1 285 ? 70.538  103.613 129.365 1.00 71.66  ? 259 LEU A C     1 
ATOM   934  O O     . LEU A 1 285 ? 69.760  103.274 130.248 1.00 73.47  ? 259 LEU A O     1 
ATOM   935  C CB    . LEU A 1 285 ? 71.978  102.194 127.785 1.00 63.53  ? 259 LEU A CB    1 
ATOM   936  C CG    . LEU A 1 285 ? 71.977  100.724 127.335 1.00 83.44  ? 259 LEU A CG    1 
ATOM   937  C CD1   . LEU A 1 285 ? 73.274  100.115 126.808 1.00 80.13  ? 259 LEU A CD1   1 
ATOM   938  C CD2   . LEU A 1 285 ? 71.598  99.854  128.486 1.00 92.47  ? 259 LEU A CD2   1 
ATOM   939  N N     . GLN A 1 286 ? 71.242  104.761 129.391 1.00 85.20  ? 260 GLN A N     1 
ATOM   940  C CA    . GLN A 1 286 ? 71.353  105.636 130.553 1.00 81.29  ? 260 GLN A CA    1 
ATOM   941  C C     . GLN A 1 286 ? 69.986  105.908 131.148 1.00 86.56  ? 260 GLN A C     1 
ATOM   942  O O     . GLN A 1 286 ? 69.838  105.959 132.392 1.00 69.72  ? 260 GLN A O     1 
ATOM   943  C CB    . GLN A 1 286 ? 71.891  107.007 130.191 1.00 80.14  ? 260 GLN A CB    1 
ATOM   944  C CG    . GLN A 1 286 ? 72.164  107.924 131.367 1.00 80.39  ? 260 GLN A CG    1 
ATOM   945  C CD    . GLN A 1 286 ? 73.054  109.070 130.936 1.00 89.79  ? 260 GLN A CD    1 
ATOM   946  O OE1   . GLN A 1 286 ? 72.630  109.957 130.187 1.00 110.97 ? 260 GLN A OE1   1 
ATOM   947  N NE2   . GLN A 1 286 ? 74.301  109.066 131.384 1.00 97.14  ? 260 GLN A NE2   1 
ATOM   948  N N     . ASN A 1 287 ? 69.024  106.051 130.221 1.00 79.84  ? 261 ASN A N     1 
ATOM   949  C CA    . ASN A 1 287 ? 67.644  106.278 130.607 1.00 90.00  ? 261 ASN A CA    1 
ATOM   950  C C     . ASN A 1 287 ? 67.133  105.107 131.442 1.00 67.50  ? 261 ASN A C     1 
ATOM   951  O O     . ASN A 1 287 ? 66.964  105.233 132.648 1.00 60.77  ? 261 ASN A O     1 
ATOM   952  C CB    . ASN A 1 287 ? 66.759  106.650 129.435 1.00 95.18  ? 261 ASN A CB    1 
ATOM   953  C CG    . ASN A 1 287 ? 65.949  107.869 129.797 1.00 136.53 ? 261 ASN A CG    1 
ATOM   954  O OD1   . ASN A 1 287 ? 65.802  108.202 130.986 1.00 103.75 ? 261 ASN A OD1   1 
ATOM   955  N ND2   . ASN A 1 287 ? 65.432  108.551 128.785 1.00 181.59 ? 261 ASN A ND2   1 
ATOM   956  N N     . TRP A 1 288 ? 66.942  103.951 130.828 1.00 72.71  ? 262 TRP A N     1 
ATOM   957  C CA    . TRP A 1 288 ? 66.454  102.805 131.579 1.00 87.73  ? 262 TRP A CA    1 
ATOM   958  C C     . TRP A 1 288 ? 67.163  102.674 132.927 1.00 86.77  ? 262 TRP A C     1 
ATOM   959  O O     . TRP A 1 288 ? 66.541  102.628 134.001 1.00 76.15  ? 262 TRP A O     1 
ATOM   960  C CB    . TRP A 1 288 ? 66.679  101.534 130.765 1.00 86.50  ? 262 TRP A CB    1 
ATOM   961  C CG    . TRP A 1 288 ? 65.899  101.543 129.492 1.00 91.23  ? 262 TRP A CG    1 
ATOM   962  C CD1   . TRP A 1 288 ? 64.659  102.056 129.314 1.00 90.47  ? 262 TRP A CD1   1 
ATOM   963  C CD2   . TRP A 1 288 ? 66.318  101.005 128.228 1.00 100.13 ? 262 TRP A CD2   1 
ATOM   964  N NE1   . TRP A 1 288 ? 64.278  101.883 128.015 1.00 110.90 ? 262 TRP A NE1   1 
ATOM   965  C CE2   . TRP A 1 288 ? 65.265  101.221 127.339 1.00 89.03  ? 262 TRP A CE2   1 
ATOM   966  C CE3   . TRP A 1 288 ? 67.470  100.364 127.765 1.00 125.20 ? 262 TRP A CE3   1 
ATOM   967  C CZ2   . TRP A 1 288 ? 65.336  100.812 126.023 1.00 95.33  ? 262 TRP A CZ2   1 
ATOM   968  C CZ3   . TRP A 1 288 ? 67.538  99.957  126.454 1.00 109.82 ? 262 TRP A CZ3   1 
ATOM   969  C CH2   . TRP A 1 288 ? 66.474  100.169 125.605 1.00 99.49  ? 262 TRP A CH2   1 
ATOM   970  N N     . PHE A 1 289 ? 68.481  102.566 132.845 1.00 63.15  ? 263 PHE A N     1 
ATOM   971  C CA    . PHE A 1 289 ? 69.247  102.382 134.038 1.00 58.60  ? 263 PHE A CA    1 
ATOM   972  C C     . PHE A 1 289 ? 68.813  103.369 135.098 1.00 70.08  ? 263 PHE A C     1 
ATOM   973  O O     . PHE A 1 289 ? 68.548  102.902 136.223 1.00 61.36  ? 263 PHE A O     1 
ATOM   974  C CB    . PHE A 1 289 ? 70.711  102.600 133.721 1.00 65.83  ? 263 PHE A CB    1 
ATOM   975  C CG    . PHE A 1 289 ? 71.395  101.280 133.470 1.00 59.72  ? 263 PHE A CG    1 
ATOM   976  C CD1   . PHE A 1 289 ? 71.897  100.537 134.538 1.00 67.95  ? 263 PHE A CD1   1 
ATOM   977  C CD2   . PHE A 1 289 ? 71.494  100.800 132.189 1.00 58.75  ? 263 PHE A CD2   1 
ATOM   978  C CE1   . PHE A 1 289 ? 72.522  99.332  134.342 1.00 59.92  ? 263 PHE A CE1   1 
ATOM   979  C CE2   . PHE A 1 289 ? 72.090  99.585  131.979 1.00 71.46  ? 263 PHE A CE2   1 
ATOM   980  C CZ    . PHE A 1 289 ? 72.602  98.861  133.062 1.00 90.11  ? 263 PHE A CZ    1 
ATOM   981  N N     . THR A 1 290 ? 68.742  104.684 134.730 1.00 63.62  ? 264 THR A N     1 
ATOM   982  C CA    . THR A 1 290 ? 68.387  105.696 135.732 1.00 76.07  ? 264 THR A CA    1 
ATOM   983  C C     . THR A 1 290 ? 66.948  105.557 136.267 1.00 64.06  ? 264 THR A C     1 
ATOM   984  O O     . THR A 1 290 ? 66.756  105.544 137.484 1.00 57.05  ? 264 THR A O     1 
ATOM   985  C CB    . THR A 1 290 ? 68.598  107.130 135.318 1.00 74.14  ? 264 THR A CB    1 
ATOM   986  O OG1   . THR A 1 290 ? 67.768  107.746 136.311 1.00 59.51  ? 264 THR A OG1   1 
ATOM   987  C CG2   . THR A 1 290 ? 67.899  107.446 134.022 1.00 116.47 ? 264 THR A CG2   1 
ATOM   988  N N     . ILE A 1 291 ? 65.952  105.341 135.407 1.00 63.82  ? 265 ILE A N     1 
ATOM   989  C CA    . ILE A 1 291 ? 64.597  105.119 135.888 1.00 74.98  ? 265 ILE A CA    1 
ATOM   990  C C     . ILE A 1 291 ? 64.524  103.943 136.877 1.00 73.41  ? 265 ILE A C     1 
ATOM   991  O O     . ILE A 1 291 ? 64.129  104.064 138.050 1.00 57.16  ? 265 ILE A O     1 
ATOM   992  C CB    . ILE A 1 291 ? 63.633  104.920 134.724 1.00 74.33  ? 265 ILE A CB    1 
ATOM   993  C CG1   . ILE A 1 291 ? 63.895  105.955 133.663 1.00 105.40 ? 265 ILE A CG1   1 
ATOM   994  C CG2   . ILE A 1 291 ? 62.217  105.026 135.276 1.00 73.45  ? 265 ILE A CG2   1 
ATOM   995  C CD1   . ILE A 1 291 ? 63.408  105.591 132.276 1.00 125.59 ? 265 ILE A CD1   1 
ATOM   996  N N     . VAL A 1 292 ? 64.955  102.783 136.437 1.00 63.94  ? 266 VAL A N     1 
ATOM   997  C CA    . VAL A 1 292 ? 64.917  101.694 137.376 1.00 63.62  ? 266 VAL A CA    1 
ATOM   998  C C     . VAL A 1 292 ? 65.752  102.014 138.611 1.00 70.63  ? 266 VAL A C     1 
ATOM   999  O O     . VAL A 1 292 ? 65.548  101.404 139.664 1.00 68.07  ? 266 VAL A O     1 
ATOM   1000 C CB    . VAL A 1 292 ? 65.465  100.432 136.733 1.00 66.93  ? 266 VAL A CB    1 
ATOM   1001 C CG1   . VAL A 1 292 ? 65.058  99.252  137.573 1.00 66.32  ? 266 VAL A CG1   1 
ATOM   1002 C CG2   . VAL A 1 292 ? 64.898  100.256 135.355 1.00 102.14 ? 266 VAL A CG2   1 
ATOM   1003 N N     . ALA A 1 293 ? 66.766  102.881 138.502 1.00 65.85  ? 267 ALA A N     1 
ATOM   1004 C CA    . ALA A 1 293 ? 67.549  103.137 139.700 1.00 69.98  ? 267 ALA A CA    1 
ATOM   1005 C C     . ALA A 1 293 ? 66.884  104.196 140.585 1.00 86.94  ? 267 ALA A C     1 
ATOM   1006 O O     . ALA A 1 293 ? 66.940  104.027 141.805 1.00 76.47  ? 267 ALA A O     1 
ATOM   1007 C CB    . ALA A 1 293 ? 68.968  103.457 139.368 1.00 64.77  ? 267 ALA A CB    1 
ATOM   1008 N N     . GLU A 1 294 ? 66.182  105.201 140.009 1.00 70.67  ? 268 GLU A N     1 
ATOM   1009 C CA    . GLU A 1 294 ? 65.300  106.026 140.827 1.00 78.05  ? 268 GLU A CA    1 
ATOM   1010 C C     . GLU A 1 294 ? 64.276  105.118 141.530 1.00 87.03  ? 268 GLU A C     1 
ATOM   1011 O O     . GLU A 1 294 ? 64.179  105.123 142.769 1.00 72.76  ? 268 GLU A O     1 
ATOM   1012 C CB    . GLU A 1 294 ? 64.539  107.167 140.156 1.00 109.13 ? 268 GLU A CB    1 
ATOM   1013 C CG    . GLU A 1 294 ? 65.370  108.163 139.328 1.00 167.58 ? 268 GLU A CG    1 
ATOM   1014 C CD    . GLU A 1 294 ? 64.682  109.026 138.229 1.00 169.77 ? 268 GLU A CD    1 
ATOM   1015 O OE1   . GLU A 1 294 ? 64.309  108.558 137.089 1.00 85.82  ? 268 GLU A OE1   1 
ATOM   1016 O OE2   . GLU A 1 294 ? 64.514  110.244 138.531 1.00 143.69 ? 268 GLU A OE2   1 
ATOM   1017 N N     . SER A 1 295 ? 63.545  104.288 140.765 1.00 72.25  ? 269 SER A N     1 
ATOM   1018 C CA    . SER A 1 295 ? 62.416  103.552 141.333 1.00 68.17  ? 269 SER A CA    1 
ATOM   1019 C C     . SER A 1 295 ? 62.828  102.762 142.567 1.00 74.38  ? 269 SER A C     1 
ATOM   1020 O O     . SER A 1 295 ? 62.131  102.771 143.575 1.00 101.32 ? 269 SER A O     1 
ATOM   1021 C CB    . SER A 1 295 ? 61.779  102.641 140.378 1.00 58.40  ? 269 SER A CB    1 
ATOM   1022 O OG    . SER A 1 295 ? 61.492  103.300 139.156 1.00 83.21  ? 269 SER A OG    1 
ATOM   1023 N N     . LEU A 1 296 ? 63.971  102.097 142.532 1.00 76.85  ? 270 LEU A N     1 
ATOM   1024 C CA    . LEU A 1 296 ? 64.362  101.398 143.734 1.00 69.31  ? 270 LEU A CA    1 
ATOM   1025 C C     . LEU A 1 296 ? 64.427  102.409 144.864 1.00 75.58  ? 270 LEU A C     1 
ATOM   1026 O O     . LEU A 1 296 ? 63.681  102.229 145.837 1.00 57.93  ? 270 LEU A O     1 
ATOM   1027 C CB    . LEU A 1 296 ? 65.657  100.665 143.452 1.00 60.63  ? 270 LEU A CB    1 
ATOM   1028 C CG    . LEU A 1 296 ? 65.418  99.433  142.578 1.00 63.52  ? 270 LEU A CG    1 
ATOM   1029 C CD1   . LEU A 1 296 ? 66.755  98.912  142.031 1.00 58.44  ? 270 LEU A CD1   1 
ATOM   1030 C CD2   . LEU A 1 296 ? 64.566  98.397  143.391 1.00 53.91  ? 270 LEU A CD2   1 
ATOM   1031 N N     . GLN A 1 297 ? 65.165  103.525 144.628 1.00 74.62  ? 271 GLN A N     1 
ATOM   1032 C CA    . GLN A 1 297 ? 65.437  104.505 145.674 1.00 64.06  ? 271 GLN A CA    1 
ATOM   1033 C C     . GLN A 1 297 ? 64.148  104.860 146.385 1.00 74.99  ? 271 GLN A C     1 
ATOM   1034 O O     . GLN A 1 297 ? 64.121  104.823 147.615 1.00 83.06  ? 271 GLN A O     1 
ATOM   1035 C CB    . GLN A 1 297 ? 66.174  105.805 145.397 1.00 65.00  ? 271 GLN A CB    1 
ATOM   1036 C CG    . GLN A 1 297 ? 67.698  105.659 145.501 1.00 91.62  ? 271 GLN A CG    1 
ATOM   1037 C CD    . GLN A 1 297 ? 68.531  106.938 145.432 1.00 128.37 ? 271 GLN A CD    1 
ATOM   1038 O OE1   . GLN A 1 297 ? 68.364  107.808 144.559 1.00 114.23 ? 271 GLN A OE1   1 
ATOM   1039 N NE2   . GLN A 1 297 ? 69.504  107.039 146.334 1.00 143.80 ? 271 GLN A NE2   1 
ATOM   1040 N N     . GLN A 1 298 ? 63.067  105.045 145.623 1.00 81.92  ? 272 GLN A N     1 
ATOM   1041 C CA    . GLN A 1 298 ? 61.753  105.256 146.224 1.00 85.48  ? 272 GLN A CA    1 
ATOM   1042 C C     . GLN A 1 298 ? 61.304  104.036 147.019 1.00 81.70  ? 272 GLN A C     1 
ATOM   1043 O O     . GLN A 1 298 ? 60.764  104.163 148.125 1.00 73.85  ? 272 GLN A O     1 
ATOM   1044 C CB    . GLN A 1 298 ? 60.683  105.552 145.185 1.00 102.41 ? 272 GLN A CB    1 
ATOM   1045 C CG    . GLN A 1 298 ? 59.507  106.401 145.665 1.00 103.62 ? 272 GLN A CG    1 
ATOM   1046 C CD    . GLN A 1 298 ? 58.871  107.153 144.501 1.00 152.02 ? 272 GLN A CD    1 
ATOM   1047 O OE1   . GLN A 1 298 ? 59.300  107.089 143.325 1.00 106.76 ? 272 GLN A OE1   1 
ATOM   1048 N NE2   . GLN A 1 298 ? 57.814  107.882 144.834 1.00 168.84 ? 272 GLN A NE2   1 
ATOM   1049 N N     . VAL A 1 299 ? 61.530  102.847 146.472 1.00 70.11  ? 273 VAL A N     1 
ATOM   1050 C CA    . VAL A 1 299 ? 61.125  101.690 147.237 1.00 78.47  ? 273 VAL A CA    1 
ATOM   1051 C C     . VAL A 1 299 ? 61.986  101.599 148.494 1.00 93.66  ? 273 VAL A C     1 
ATOM   1052 O O     . VAL A 1 299 ? 61.649  100.877 149.447 1.00 88.28  ? 273 VAL A O     1 
ATOM   1053 C CB    . VAL A 1 299 ? 61.220  100.399 146.435 1.00 66.39  ? 273 VAL A CB    1 
ATOM   1054 C CG1   . VAL A 1 299 ? 60.563  99.252  147.170 1.00 65.37  ? 273 VAL A CG1   1 
ATOM   1055 C CG2   . VAL A 1 299 ? 60.542  100.542 145.113 1.00 80.53  ? 273 VAL A CG2   1 
ATOM   1056 N N     . ARG A 1 300 ? 63.126  102.300 148.488 1.00 69.24  ? 274 ARG A N     1 
ATOM   1057 C CA    . ARG A 1 300 ? 63.899  102.268 149.696 1.00 74.32  ? 274 ARG A CA    1 
ATOM   1058 C C     . ARG A 1 300 ? 63.071  102.981 150.748 1.00 114.54 ? 274 ARG A C     1 
ATOM   1059 O O     . ARG A 1 300 ? 62.709  102.366 151.751 1.00 130.30 ? 274 ARG A O     1 
ATOM   1060 C CB    . ARG A 1 300 ? 65.304  102.794 149.468 1.00 97.45  ? 274 ARG A CB    1 
ATOM   1061 C CG    . ARG A 1 300 ? 66.284  102.419 150.575 1.00 132.60 ? 274 ARG A CG    1 
ATOM   1062 C CD    . ARG A 1 300 ? 67.683  102.210 150.001 1.00 153.19 ? 274 ARG A CD    1 
ATOM   1063 N NE    . ARG A 1 300 ? 68.730  102.179 151.028 1.00 148.56 ? 274 ARG A NE    1 
ATOM   1064 C CZ    . ARG A 1 300 ? 69.261  101.062 151.542 1.00 169.36 ? 274 ARG A CZ    1 
ATOM   1065 N NH1   . ARG A 1 300 ? 68.680  99.869  151.403 1.00 133.52 ? 274 ARG A NH1   1 
ATOM   1066 N NH2   . ARG A 1 300 ? 70.371  101.156 152.254 1.00 186.89 ? 274 ARG A NH2   1 
ATOM   1067 N N     . GLN A 1 301 ? 62.680  104.227 150.439 1.00 112.32 ? 275 GLN A N     1 
ATOM   1068 C CA    . GLN A 1 301 ? 62.054  105.111 151.415 1.00 106.10 ? 275 GLN A CA    1 
ATOM   1069 C C     . GLN A 1 301 ? 60.762  104.519 151.981 1.00 96.57  ? 275 GLN A C     1 
ATOM   1070 O O     . GLN A 1 301 ? 60.555  104.609 153.186 1.00 103.06 ? 275 GLN A O     1 
ATOM   1071 C CB    . GLN A 1 301 ? 61.786  106.499 150.846 1.00 107.26 ? 275 GLN A CB    1 
ATOM   1072 C CG    . GLN A 1 301 ? 63.050  107.189 150.342 1.00 139.78 ? 275 GLN A CG    1 
ATOM   1073 C CD    . GLN A 1 301 ? 63.633  108.217 151.286 1.00 143.61 ? 275 GLN A CD    1 
ATOM   1074 O OE1   . GLN A 1 301 ? 64.444  107.915 152.170 1.00 122.63 ? 275 GLN A OE1   1 
ATOM   1075 N NE2   . GLN A 1 301 ? 63.263  109.467 151.047 1.00 158.90 ? 275 GLN A NE2   1 
ATOM   1076 N N     . GLN A 1 302 ? 59.904  103.902 151.156 1.00 80.79  ? 276 GLN A N     1 
ATOM   1077 C CA    . GLN A 1 302 ? 58.639  103.408 151.682 1.00 78.60  ? 276 GLN A CA    1 
ATOM   1078 C C     . GLN A 1 302 ? 58.882  102.235 152.650 1.00 86.15  ? 276 GLN A C     1 
ATOM   1079 O O     . GLN A 1 302 ? 58.121  101.934 153.600 1.00 58.79  ? 276 GLN A O     1 
ATOM   1080 C CB    . GLN A 1 302 ? 57.652  102.979 150.596 1.00 91.26  ? 276 GLN A CB    1 
ATOM   1081 C CG    . GLN A 1 302 ? 57.335  104.027 149.543 1.00 115.22 ? 276 GLN A CG    1 
ATOM   1082 C CD    . GLN A 1 302 ? 57.145  103.392 148.187 1.00 127.07 ? 276 GLN A CD    1 
ATOM   1083 O OE1   . GLN A 1 302 ? 58.093  102.889 147.564 1.00 118.05 ? 276 GLN A OE1   1 
ATOM   1084 N NE2   . GLN A 1 302 ? 55.904  103.413 147.730 1.00 128.07 ? 276 GLN A NE2   1 
ATOM   1085 N N     . LEU A 1 303 ? 59.968  101.513 152.442 1.00 90.72  ? 277 LEU A N     1 
ATOM   1086 C CA    . LEU A 1 303 ? 60.193  100.470 153.413 1.00 94.77  ? 277 LEU A CA    1 
ATOM   1087 C C     . LEU A 1 303 ? 60.539  101.068 154.761 1.00 113.02 ? 277 LEU A C     1 
ATOM   1088 O O     . LEU A 1 303 ? 60.428  100.374 155.762 1.00 139.37 ? 277 LEU A O     1 
ATOM   1089 C CB    . LEU A 1 303 ? 61.260  99.559  152.869 1.00 89.78  ? 277 LEU A CB    1 
ATOM   1090 C CG    . LEU A 1 303 ? 60.677  98.742  151.734 1.00 105.22 ? 277 LEU A CG    1 
ATOM   1091 C CD1   . LEU A 1 303 ? 61.728  97.790  151.157 1.00 106.19 ? 277 LEU A CD1   1 
ATOM   1092 C CD2   . LEU A 1 303 ? 59.396  98.086  152.321 1.00 88.52  ? 277 LEU A CD2   1 
ATOM   1093 N N     . LYS A 1 304 ? 60.893  102.359 154.771 1.00 108.24 ? 278 LYS A N     1 
ATOM   1094 C CA    . LYS A 1 304 ? 61.212  103.080 155.992 1.00 102.79 ? 278 LYS A CA    1 
ATOM   1095 C C     . LYS A 1 304 ? 59.992  103.843 156.558 1.00 103.78 ? 278 LYS A C     1 
ATOM   1096 O O     . LYS A 1 304 ? 59.918  104.151 157.753 1.00 89.37  ? 278 LYS A O     1 
ATOM   1097 C CB    . LYS A 1 304 ? 62.466  103.866 155.594 1.00 92.85  ? 278 LYS A CB    1 
ATOM   1098 C CG    . LYS A 1 304 ? 63.074  104.654 156.744 1.00 118.13 ? 278 LYS A CG    1 
ATOM   1099 C CD    . LYS A 1 304 ? 64.559  104.918 156.555 1.00 122.05 ? 278 LYS A CD    1 
ATOM   1100 C CE    . LYS A 1 304 ? 64.821  105.636 155.271 1.00 127.15 ? 278 LYS A CE    1 
ATOM   1101 N NZ    . LYS A 1 304 ? 66.155  105.312 154.760 1.00 142.79 ? 278 LYS A NZ    1 
ATOM   1102 N N     . LYS A 1 305 ? 59.017  104.145 155.697 1.00 93.37  ? 279 LYS A N     1 
ATOM   1103 C CA    . LYS A 1 305 ? 57.757  104.731 156.123 1.00 112.01 ? 279 LYS A CA    1 
ATOM   1104 C C     . LYS A 1 305 ? 56.852  103.675 156.759 1.00 112.12 ? 279 LYS A C     1 
ATOM   1105 O O     . LYS A 1 305 ? 56.100  103.896 157.718 1.00 103.59 ? 279 LYS A O     1 
ATOM   1106 C CB    . LYS A 1 305 ? 57.018  105.378 154.945 1.00 114.30 ? 279 LYS A CB    1 
ATOM   1107 C CG    . LYS A 1 305 ? 57.562  106.735 154.498 1.00 134.29 ? 279 LYS A CG    1 
ATOM   1108 C CD    . LYS A 1 305 ? 56.500  107.667 153.922 1.00 161.47 ? 279 LYS A CD    1 
ATOM   1109 C CE    . LYS A 1 305 ? 55.247  107.750 154.776 1.00 178.32 ? 279 LYS A CE    1 
ATOM   1110 N NZ    . LYS A 1 305 ? 54.266  108.755 154.346 1.00 175.50 ? 279 LYS A NZ    1 
ATOM   1111 N N     . LEU A 1 306 ? 56.888  102.502 156.174 1.00 93.34  ? 280 LEU A N     1 
ATOM   1112 C CA    . LEU A 1 306 ? 56.299  101.390 156.865 1.00 94.71  ? 280 LEU A CA    1 
ATOM   1113 C C     . LEU A 1 306 ? 57.138  101.023 158.090 1.00 124.84 ? 280 LEU A C     1 
ATOM   1114 O O     . LEU A 1 306 ? 56.612  100.505 159.068 1.00 120.36 ? 280 LEU A O     1 
ATOM   1115 C CB    . LEU A 1 306 ? 56.432  100.338 155.797 1.00 96.23  ? 280 LEU A CB    1 
ATOM   1116 C CG    . LEU A 1 306 ? 55.592  100.502 154.548 1.00 87.46  ? 280 LEU A CG    1 
ATOM   1117 C CD1   . LEU A 1 306 ? 56.192  99.628  153.464 1.00 104.82 ? 280 LEU A CD1   1 
ATOM   1118 C CD2   . LEU A 1 306 ? 54.246  100.001 154.994 1.00 100.17 ? 280 LEU A CD2   1 
ATOM   1119 N N     . GLU A 1 307 ? 58.469  101.196 158.028 1.00 108.70 ? 281 GLU A N     1 
ATOM   1120 C CA    . GLU A 1 307 ? 59.250  100.909 159.212 1.00 104.67 ? 281 GLU A CA    1 
ATOM   1121 C C     . GLU A 1 307 ? 58.671  101.782 160.315 1.00 124.12 ? 281 GLU A C     1 
ATOM   1122 O O     . GLU A 1 307 ? 58.469  101.296 161.421 1.00 163.28 ? 281 GLU A O     1 
ATOM   1123 C CB    . GLU A 1 307 ? 60.775  101.037 159.107 1.00 159.83 ? 281 GLU A CB    1 
ATOM   1124 C CG    . GLU A 1 307 ? 61.559  99.716  159.026 1.00 208.15 ? 281 GLU A CG    1 
ATOM   1125 C CD    . GLU A 1 307 ? 63.098  99.779  158.934 1.00 223.00 ? 281 GLU A CD    1 
ATOM   1126 O OE1   . GLU A 1 307 ? 63.736  99.113  158.063 1.00 170.05 ? 281 GLU A OE1   1 
ATOM   1127 O OE2   . GLU A 1 307 ? 63.687  100.523 159.757 1.00 219.16 ? 281 GLU A OE2   1 
ATOM   1128 N N     . GLU A 1 308 ? 58.316  103.032 159.983 1.00 142.06 ? 282 GLU A N     1 
ATOM   1129 C CA    . GLU A 1 308 ? 57.727  103.959 160.947 1.00 161.37 ? 282 GLU A CA    1 
ATOM   1130 C C     . GLU A 1 308 ? 56.378  103.482 161.522 1.00 135.35 ? 282 GLU A C     1 
ATOM   1131 O O     . GLU A 1 308 ? 56.231  103.307 162.745 1.00 72.62  ? 282 GLU A O     1 
ATOM   1132 C CB    . GLU A 1 308 ? 57.640  105.344 160.309 1.00 163.84 ? 282 GLU A CB    1 
ATOM   1133 C CG    . GLU A 1 308 ? 56.745  106.306 161.088 1.00 158.27 ? 282 GLU A CG    1 
ATOM   1134 C CD    . GLU A 1 308 ? 57.346  107.690 161.258 1.00 181.58 ? 282 GLU A CD    1 
ATOM   1135 O OE1   . GLU A 1 308 ? 58.463  107.983 160.748 1.00 148.35 ? 282 GLU A OE1   1 
ATOM   1136 O OE2   . GLU A 1 308 ? 56.665  108.481 161.947 1.00 216.90 ? 282 GLU A OE2   1 
ATOM   1137 N N     . LEU A 1 309 ? 55.376  103.280 160.656 1.00 112.26 ? 283 LEU A N     1 
ATOM   1138 C CA    . LEU A 1 309 ? 54.085  102.820 161.147 1.00 111.62 ? 283 LEU A CA    1 
ATOM   1139 C C     . LEU A 1 309 ? 54.251  101.668 162.149 1.00 107.16 ? 283 LEU A C     1 
ATOM   1140 O O     . LEU A 1 309 ? 53.478  101.564 163.092 1.00 127.39 ? 283 LEU A O     1 
ATOM   1141 C CB    . LEU A 1 309 ? 53.110  102.379 160.062 1.00 111.82 ? 283 LEU A CB    1 
ATOM   1142 C CG    . LEU A 1 309 ? 52.707  103.391 158.992 1.00 117.28 ? 283 LEU A CG    1 
ATOM   1143 C CD1   . LEU A 1 309 ? 51.280  103.035 158.482 1.00 101.09 ? 283 LEU A CD1   1 
ATOM   1144 C CD2   . LEU A 1 309 ? 52.810  104.805 159.508 1.00 130.94 ? 283 LEU A CD2   1 
ATOM   1145 N N     . GLU A 1 310 ? 55.203  100.757 161.942 1.00 126.98 ? 284 GLU A N     1 
ATOM   1146 C CA    . GLU A 1 310 ? 55.378  99.661  162.882 1.00 135.94 ? 284 GLU A CA    1 
ATOM   1147 C C     . GLU A 1 310 ? 55.864  100.264 164.202 1.00 164.33 ? 284 GLU A C     1 
ATOM   1148 O O     . GLU A 1 310 ? 55.385  99.909  165.279 1.00 170.84 ? 284 GLU A O     1 
ATOM   1149 C CB    . GLU A 1 310 ? 56.299  98.609  162.274 1.00 113.58 ? 284 GLU A CB    1 
ATOM   1150 C CG    . GLU A 1 310 ? 56.569  97.426  163.190 1.00 167.34 ? 284 GLU A CG    1 
ATOM   1151 C CD    . GLU A 1 310 ? 57.903  97.492  163.924 1.00 284.63 ? 284 GLU A CD    1 
ATOM   1152 O OE1   . GLU A 1 310 ? 58.561  98.556  163.902 1.00 329.45 ? 284 GLU A OE1   1 
ATOM   1153 O OE2   . GLU A 1 310 ? 58.301  96.453  164.503 1.00 328.11 ? 284 GLU A OE2   1 
ATOM   1154 N N     . GLN A 1 311 ? 56.775  101.237 164.094 1.00 155.84 ? 285 GLN A N     1 
ATOM   1155 C CA    . GLN A 1 311 ? 57.282  101.968 165.244 1.00 179.34 ? 285 GLN A CA    1 
ATOM   1156 C C     . GLN A 1 311 ? 56.250  103.000 165.705 1.00 162.48 ? 285 GLN A C     1 
ATOM   1157 O O     . GLN A 1 311 ? 56.570  103.954 166.421 1.00 155.09 ? 285 GLN A O     1 
ATOM   1158 C CB    . GLN A 1 311 ? 58.623  102.630 164.913 1.00 221.52 ? 285 GLN A CB    1 
ATOM   1159 C CG    . GLN A 1 311 ? 59.800  101.665 164.778 1.00 209.72 ? 285 GLN A CG    1 
ATOM   1160 C CD    . GLN A 1 311 ? 60.838  102.097 163.755 1.00 212.62 ? 285 GLN A CD    1 
ATOM   1161 O OE1   . GLN A 1 311 ? 60.881  103.242 163.285 1.00 170.22 ? 285 GLN A OE1   1 
ATOM   1162 N NE2   . GLN A 1 311 ? 61.704  101.162 163.391 1.00 219.92 ? 285 GLN A NE2   1 
ATOM   1163 N N     . LYS A 1 312 ? 55.003  102.809 165.289 1.00 127.29 ? 286 LYS A N     1 
ATOM   1164 C CA    . LYS A 1 312 ? 53.900  103.318 166.073 1.00 150.19 ? 286 LYS A CA    1 
ATOM   1165 C C     . LYS A 1 312 ? 53.267  102.086 166.703 1.00 158.12 ? 286 LYS A C     1 
ATOM   1166 O O     . LYS A 1 312 ? 53.585  101.724 167.833 1.00 188.95 ? 286 LYS A O     1 
ATOM   1167 C CB    . LYS A 1 312 ? 52.949  104.182 165.229 1.00 175.98 ? 286 LYS A CB    1 
ATOM   1168 C CG    . LYS A 1 312 ? 53.250  105.692 165.135 1.00 192.36 ? 286 LYS A CG    1 
ATOM   1169 C CD    . LYS A 1 312 ? 52.316  106.466 164.197 1.00 193.99 ? 286 LYS A CD    1 
ATOM   1170 C CE    . LYS A 1 312 ? 52.482  107.975 164.142 1.00 203.27 ? 286 LYS A CE    1 
ATOM   1171 N NZ    . LYS A 1 312 ? 53.493  108.519 163.217 1.00 184.18 ? 286 LYS A NZ    1 
ATOM   1172 N N     . TYR A 1 313 ? 52.461  101.390 165.902 1.00 161.90 ? 287 TYR A N     1 
ATOM   1173 C CA    . TYR A 1 313 ? 51.473  100.454 166.400 1.00 169.02 ? 287 TYR A CA    1 
ATOM   1174 C C     . TYR A 1 313 ? 51.756  99.051  165.867 1.00 217.19 ? 287 TYR A C     1 
ATOM   1175 O O     . TYR A 1 313 ? 52.090  98.897  164.691 1.00 251.32 ? 287 TYR A O     1 
ATOM   1176 C CB    . TYR A 1 313 ? 50.145  101.012 165.900 1.00 130.66 ? 287 TYR A CB    1 
ATOM   1177 C CG    . TYR A 1 313 ? 48.973  100.080 166.148 1.00 167.80 ? 287 TYR A CG    1 
ATOM   1178 C CD1   . TYR A 1 313 ? 48.686  99.000  165.308 1.00 138.08 ? 287 TYR A CD1   1 
ATOM   1179 C CD2   . TYR A 1 313 ? 48.126  100.317 167.225 1.00 218.11 ? 287 TYR A CD2   1 
ATOM   1180 C CE1   . TYR A 1 313 ? 47.582  98.193  165.544 1.00 181.35 ? 287 TYR A CE1   1 
ATOM   1181 C CE2   . TYR A 1 313 ? 47.020  99.519  167.464 1.00 240.77 ? 287 TYR A CE2   1 
ATOM   1182 C CZ    . TYR A 1 313 ? 46.748  98.454  166.625 1.00 221.47 ? 287 TYR A CZ    1 
ATOM   1183 O OH    . TYR A 1 313 ? 45.651  97.699  166.932 1.00 213.93 ? 287 TYR A OH    1 
ATOM   1184 N N     . THR A 1 314 ? 51.598  98.036  166.735 1.00 192.47 ? 288 THR A N     1 
ATOM   1185 C CA    . THR A 1 314 ? 51.900  96.649  166.391 1.00 128.94 ? 288 THR A CA    1 
ATOM   1186 C C     . THR A 1 314 ? 51.003  95.708  167.195 1.00 95.82  ? 288 THR A C     1 
ATOM   1187 O O     . THR A 1 314 ? 50.166  96.119  167.994 1.00 79.98  ? 288 THR A O     1 
ATOM   1188 C CB    . THR A 1 314 ? 53.394  96.410  166.595 1.00 119.61 ? 288 THR A CB    1 
ATOM   1189 O OG1   . THR A 1 314 ? 54.023  97.417  165.809 1.00 133.60 ? 288 THR A OG1   1 
ATOM   1190 C CG2   . THR A 1 314 ? 53.912  95.115  166.009 1.00 138.80 ? 288 THR A CG2   1 
ATOM   1191 N N     . TYR A 1 315 ? 51.055  94.431  166.868 1.00 113.42 ? 289 TYR A N     1 
ATOM   1192 C CA    . TYR A 1 315 ? 49.992  93.540  167.282 1.00 146.08 ? 289 TYR A CA    1 
ATOM   1193 C C     . TYR A 1 315 ? 50.344  92.133  166.805 1.00 159.80 ? 289 TYR A C     1 
ATOM   1194 O O     . TYR A 1 315 ? 51.476  91.865  166.394 1.00 153.52 ? 289 TYR A O     1 
ATOM   1195 C CB    . TYR A 1 315 ? 48.654  94.074  166.753 1.00 169.41 ? 289 TYR A CB    1 
ATOM   1196 C CG    . TYR A 1 315 ? 48.507  94.083  165.233 1.00 181.67 ? 289 TYR A CG    1 
ATOM   1197 C CD1   . TYR A 1 315 ? 48.940  95.159  164.460 1.00 152.90 ? 289 TYR A CD1   1 
ATOM   1198 C CD2   . TYR A 1 315 ? 47.905  93.017  164.570 1.00 177.24 ? 289 TYR A CD2   1 
ATOM   1199 C CE1   . TYR A 1 315 ? 48.802  95.153  163.082 1.00 142.32 ? 289 TYR A CE1   1 
ATOM   1200 C CE2   . TYR A 1 315 ? 47.744  93.013  163.196 1.00 140.33 ? 289 TYR A CE2   1 
ATOM   1201 C CZ    . TYR A 1 315 ? 48.201  94.079  162.450 1.00 137.58 ? 289 TYR A CZ    1 
ATOM   1202 O OH    . TYR A 1 315 ? 48.026  94.054  161.100 1.00 130.87 ? 289 TYR A OH    1 
ATOM   1203 N N     . GLU A 1 316 ? 49.368  91.232  166.886 1.00 152.78 ? 290 GLU A N     1 
ATOM   1204 C CA    . GLU A 1 316 ? 49.688  89.825  166.979 1.00 165.80 ? 290 GLU A CA    1 
ATOM   1205 C C     . GLU A 1 316 ? 50.491  89.440  165.740 1.00 182.49 ? 290 GLU A C     1 
ATOM   1206 O O     . GLU A 1 316 ? 51.686  89.161  165.865 1.00 184.65 ? 290 GLU A O     1 
ATOM   1207 C CB    . GLU A 1 316 ? 48.393  89.067  167.272 1.00 215.42 ? 290 GLU A CB    1 
ATOM   1208 C CG    . GLU A 1 316 ? 48.590  87.837  168.162 1.00 260.24 ? 290 GLU A CG    1 
ATOM   1209 C CD    . GLU A 1 316 ? 48.960  88.038  169.635 1.00 232.56 ? 290 GLU A CD    1 
ATOM   1210 O OE1   . GLU A 1 316 ? 50.072  88.547  169.942 1.00 150.86 ? 290 GLU A OE1   1 
ATOM   1211 O OE2   . GLU A 1 316 ? 48.127  87.639  170.494 1.00 190.00 ? 290 GLU A OE2   1 
ATOM   1212 N N     . HIS A 1 317 ? 49.838  89.496  164.564 1.00 185.45 ? 291 HIS A N     1 
ATOM   1213 C CA    . HIS A 1 317 ? 50.476  89.226  163.277 1.00 191.15 ? 291 HIS A CA    1 
ATOM   1214 C C     . HIS A 1 317 ? 50.563  90.535  162.481 1.00 178.09 ? 291 HIS A C     1 
ATOM   1215 O O     . HIS A 1 317 ? 49.552  91.020  161.979 1.00 200.57 ? 291 HIS A O     1 
ATOM   1216 C CB    . HIS A 1 317 ? 49.710  88.154  162.485 1.00 173.66 ? 291 HIS A CB    1 
ATOM   1217 C CG    . HIS A 1 317 ? 48.769  87.319  163.291 1.00 197.53 ? 291 HIS A CG    1 
ATOM   1218 N ND1   . HIS A 1 317 ? 47.394  87.443  163.219 1.00 196.34 ? 291 HIS A ND1   1 
ATOM   1219 C CD2   . HIS A 1 317 ? 49.005  86.332  164.165 1.00 243.59 ? 291 HIS A CD2   1 
ATOM   1220 C CE1   . HIS A 1 317 ? 46.826  86.565  164.039 1.00 209.89 ? 291 HIS A CE1   1 
ATOM   1221 N NE2   . HIS A 1 317 ? 47.788  85.882  164.628 1.00 247.69 ? 291 HIS A NE2   1 
ATOM   1222 N N     . ASP A 1 318 ? 51.769  91.110  162.363 1.00 124.63 ? 292 ASP A N     1 
ATOM   1223 C CA    . ASP A 1 318 ? 51.927  92.434  161.790 1.00 117.16 ? 292 ASP A CA    1 
ATOM   1224 C C     . ASP A 1 318 ? 52.574  92.353  160.412 1.00 97.40  ? 292 ASP A C     1 
ATOM   1225 O O     . ASP A 1 318 ? 53.795  92.458  160.300 1.00 89.37  ? 292 ASP A O     1 
ATOM   1226 C CB    . ASP A 1 318 ? 52.723  93.359  162.696 1.00 144.45 ? 292 ASP A CB    1 
ATOM   1227 C CG    . ASP A 1 318 ? 52.710  94.831  162.284 1.00 187.13 ? 292 ASP A CG    1 
ATOM   1228 O OD1   . ASP A 1 318 ? 51.831  95.203  161.465 1.00 196.38 ? 292 ASP A OD1   1 
ATOM   1229 O OD2   . ASP A 1 318 ? 53.570  95.609  162.784 1.00 168.94 ? 292 ASP A OD2   1 
ATOM   1230 N N     . PRO A 1 319 ? 51.768  92.309  159.323 1.00 100.66 ? 293 PRO A N     1 
ATOM   1231 C CA    . PRO A 1 319 ? 52.243  91.995  157.976 1.00 94.43  ? 293 PRO A CA    1 
ATOM   1232 C C     . PRO A 1 319 ? 53.632  92.487  157.718 1.00 85.52  ? 293 PRO A C     1 
ATOM   1233 O O     . PRO A 1 319 ? 54.261  91.889  156.853 1.00 83.89  ? 293 PRO A O     1 
ATOM   1234 C CB    . PRO A 1 319 ? 51.280  92.754  157.086 1.00 98.68  ? 293 PRO A CB    1 
ATOM   1235 C CG    . PRO A 1 319 ? 49.964  92.590  157.808 1.00 122.51 ? 293 PRO A CG    1 
ATOM   1236 C CD    . PRO A 1 319 ? 50.336  92.635  159.302 1.00 122.24 ? 293 PRO A CD    1 
ATOM   1237 N N     . ILE A 1 320 ? 53.989  93.591  158.430 1.00 90.11  ? 294 ILE A N     1 
ATOM   1238 C CA    . ILE A 1 320 ? 55.202  94.357  158.185 1.00 99.49  ? 294 ILE A CA    1 
ATOM   1239 C C     . ILE A 1 320 ? 56.201  94.107  159.284 1.00 112.17 ? 294 ILE A C     1 
ATOM   1240 O O     . ILE A 1 320 ? 57.072  94.944  159.499 1.00 149.47 ? 294 ILE A O     1 
ATOM   1241 C CB    . ILE A 1 320 ? 54.981  95.872  158.066 1.00 112.69 ? 294 ILE A CB    1 
ATOM   1242 C CG1   . ILE A 1 320 ? 54.740  96.493  159.364 1.00 102.11 ? 294 ILE A CG1   1 
ATOM   1243 C CG2   . ILE A 1 320 ? 53.861  96.229  157.084 1.00 167.74 ? 294 ILE A CG2   1 
ATOM   1244 C CD1   . ILE A 1 320 ? 54.760  98.000  159.248 1.00 159.85 ? 294 ILE A CD1   1 
ATOM   1245 N N     . THR A 1 321 ? 56.093  92.953  159.941 1.00 117.15 ? 295 THR A N     1 
ATOM   1246 C CA    . THR A 1 321 ? 57.153  92.520  160.830 1.00 110.28 ? 295 THR A CA    1 
ATOM   1247 C C     . THR A 1 321 ? 57.798  91.255  160.279 1.00 103.39 ? 295 THR A C     1 
ATOM   1248 O O     . THR A 1 321 ? 59.003  91.100  160.455 1.00 101.62 ? 295 THR A O     1 
ATOM   1249 C CB    . THR A 1 321 ? 56.608  92.395  162.249 1.00 122.68 ? 295 THR A CB    1 
ATOM   1250 O OG1   . THR A 1 321 ? 55.248  91.959  162.206 1.00 82.99  ? 295 THR A OG1   1 
ATOM   1251 C CG2   . THR A 1 321 ? 56.672  93.734  162.968 1.00 132.55 ? 295 THR A CG2   1 
ATOM   1252 N N     . LYS A 1 322 ? 57.021  90.424  159.550 1.00 116.88 ? 296 LYS A N     1 
ATOM   1253 C CA    . LYS A 1 322 ? 57.540  89.237  158.865 1.00 147.77 ? 296 LYS A CA    1 
ATOM   1254 C C     . LYS A 1 322 ? 58.270  89.647  157.583 1.00 156.12 ? 296 LYS A C     1 
ATOM   1255 O O     . LYS A 1 322 ? 59.207  88.983  157.123 1.00 148.34 ? 296 LYS A O     1 
ATOM   1256 C CB    . LYS A 1 322 ? 56.466  88.186  158.546 1.00 122.88 ? 296 LYS A CB    1 
ATOM   1257 C CG    . LYS A 1 322 ? 55.417  88.116  159.634 1.00 170.55 ? 296 LYS A CG    1 
ATOM   1258 C CD    . LYS A 1 322 ? 54.491  86.906  159.644 1.00 232.69 ? 296 LYS A CD    1 
ATOM   1259 C CE    . LYS A 1 322 ? 53.341  87.042  160.635 1.00 254.63 ? 296 LYS A CE    1 
ATOM   1260 N NZ    . LYS A 1 322 ? 53.644  86.802  162.055 1.00 212.51 ? 296 LYS A NZ    1 
ATOM   1261 N N     . ASN A 1 323 ? 57.854  90.789  157.042 1.00 145.61 ? 297 ASN A N     1 
ATOM   1262 C CA    . ASN A 1 323 ? 58.260  91.196  155.716 1.00 136.76 ? 297 ASN A CA    1 
ATOM   1263 C C     . ASN A 1 323 ? 59.444  92.171  155.779 1.00 132.95 ? 297 ASN A C     1 
ATOM   1264 O O     . ASN A 1 323 ? 60.215  92.295  154.829 1.00 152.96 ? 297 ASN A O     1 
ATOM   1265 C CB    . ASN A 1 323 ? 57.001  91.631  154.979 1.00 101.65 ? 297 ASN A CB    1 
ATOM   1266 C CG    . ASN A 1 323 ? 56.140  90.453  154.575 1.00 94.85  ? 297 ASN A CG    1 
ATOM   1267 O OD1   . ASN A 1 323 ? 54.895  90.489  154.638 1.00 79.31  ? 297 ASN A OD1   1 
ATOM   1268 N ND2   . ASN A 1 323 ? 56.804  89.424  154.069 1.00 107.59 ? 297 ASN A ND2   1 
ATOM   1269 N N     . LYS A 1 324 ? 59.651  92.788  156.929 1.00 95.80  ? 298 LYS A N     1 
ATOM   1270 C CA    . LYS A 1 324 ? 60.595  93.872  157.048 1.00 99.49  ? 298 LYS A CA    1 
ATOM   1271 C C     . LYS A 1 324 ? 61.989  93.528  156.509 1.00 101.12 ? 298 LYS A C     1 
ATOM   1272 O O     . LYS A 1 324 ? 62.598  94.308  155.789 1.00 77.08  ? 298 LYS A O     1 
ATOM   1273 C CB    . LYS A 1 324 ? 60.610  94.178  158.546 1.00 146.72 ? 298 LYS A CB    1 
ATOM   1274 C CG    . LYS A 1 324 ? 61.152  95.540  158.974 1.00 191.63 ? 298 LYS A CG    1 
ATOM   1275 C CD    . LYS A 1 324 ? 60.704  95.971  160.372 1.00 195.51 ? 298 LYS A CD    1 
ATOM   1276 C CE    . LYS A 1 324 ? 60.547  94.824  161.347 1.00 181.00 ? 298 LYS A CE    1 
ATOM   1277 N NZ    . LYS A 1 324 ? 60.073  95.250  162.667 1.00 166.13 ? 298 LYS A NZ    1 
ATOM   1278 N N     . GLN A 1 325 ? 62.588  92.417  156.932 1.00 139.80 ? 299 GLN A N     1 
ATOM   1279 C CA    . GLN A 1 325 ? 64.025  92.276  156.700 1.00 160.39 ? 299 GLN A CA    1 
ATOM   1280 C C     . GLN A 1 325 ? 64.260  91.657  155.330 1.00 130.18 ? 299 GLN A C     1 
ATOM   1281 O O     . GLN A 1 325 ? 65.193  92.005  154.607 1.00 84.56  ? 299 GLN A O     1 
ATOM   1282 C CB    . GLN A 1 325 ? 64.766  91.415  157.728 1.00 185.55 ? 299 GLN A CB    1 
ATOM   1283 C CG    . GLN A 1 325 ? 66.255  91.728  157.852 1.00 159.56 ? 299 GLN A CG    1 
ATOM   1284 C CD    . GLN A 1 325 ? 66.526  93.108  158.423 1.00 194.48 ? 299 GLN A CD    1 
ATOM   1285 O OE1   . GLN A 1 325 ? 65.630  93.798  158.928 1.00 176.21 ? 299 GLN A OE1   1 
ATOM   1286 N NE2   . GLN A 1 325 ? 67.780  93.536  158.345 1.00 222.87 ? 299 GLN A NE2   1 
ATOM   1287 N N     . VAL A 1 326 ? 63.414  90.696  154.986 1.00 129.29 ? 300 VAL A N     1 
ATOM   1288 C CA    . VAL A 1 326 ? 63.572  90.099  153.684 1.00 114.69 ? 300 VAL A CA    1 
ATOM   1289 C C     . VAL A 1 326 ? 63.483  91.241  152.686 1.00 106.72 ? 300 VAL A C     1 
ATOM   1290 O O     . VAL A 1 326 ? 64.412  91.399  151.899 1.00 120.12 ? 300 VAL A O     1 
ATOM   1291 C CB    . VAL A 1 326 ? 62.570  88.972  153.403 1.00 133.96 ? 300 VAL A CB    1 
ATOM   1292 C CG1   . VAL A 1 326 ? 61.117  89.459  153.378 1.00 138.82 ? 300 VAL A CG1   1 
ATOM   1293 C CG2   . VAL A 1 326 ? 62.977  88.196  152.152 1.00 130.27 ? 300 VAL A CG2   1 
ATOM   1294 N N     . LEU A 1 327 ? 62.435  92.080  152.803 1.00 90.80  ? 301 LEU A N     1 
ATOM   1295 C CA    . LEU A 1 327 ? 62.227  93.163  151.856 1.00 87.55  ? 301 LEU A CA    1 
ATOM   1296 C C     . LEU A 1 327 ? 63.470  94.037  151.765 1.00 91.03  ? 301 LEU A C     1 
ATOM   1297 O O     . LEU A 1 327 ? 64.083  94.174  150.693 1.00 86.85  ? 301 LEU A O     1 
ATOM   1298 C CB    . LEU A 1 327 ? 60.994  93.998  152.150 1.00 61.34  ? 301 LEU A CB    1 
ATOM   1299 C CG    . LEU A 1 327 ? 59.765  93.365  151.510 1.00 69.91  ? 301 LEU A CG    1 
ATOM   1300 C CD1   . LEU A 1 327 ? 58.544  93.768  152.222 1.00 83.35  ? 301 LEU A CD1   1 
ATOM   1301 C CD2   . LEU A 1 327 ? 59.593  93.791  150.078 1.00 72.68  ? 301 LEU A CD2   1 
ATOM   1302 N N     . TRP A 1 328 ? 63.835  94.597  152.911 1.00 71.43  ? 302 TRP A N     1 
ATOM   1303 C CA    . TRP A 1 328 ? 64.918  95.547  152.945 1.00 68.57  ? 302 TRP A CA    1 
ATOM   1304 C C     . TRP A 1 328 ? 66.109  94.991  152.180 1.00 82.55  ? 302 TRP A C     1 
ATOM   1305 O O     . TRP A 1 328 ? 66.755  95.715  151.420 1.00 89.97  ? 302 TRP A O     1 
ATOM   1306 C CB    . TRP A 1 328 ? 65.299  95.885  154.386 1.00 75.57  ? 302 TRP A CB    1 
ATOM   1307 C CG    . TRP A 1 328 ? 66.273  97.009  154.337 1.00 90.99  ? 302 TRP A CG    1 
ATOM   1308 C CD1   . TRP A 1 328 ? 67.593  96.938  154.016 1.00 111.47 ? 302 TRP A CD1   1 
ATOM   1309 C CD2   . TRP A 1 328 ? 65.940  98.401  154.444 1.00 120.18 ? 302 TRP A CD2   1 
ATOM   1310 N NE1   . TRP A 1 328 ? 68.123  98.198  153.979 1.00 144.46 ? 302 TRP A NE1   1 
ATOM   1311 C CE2   . TRP A 1 328 ? 67.131  99.114  154.216 1.00 130.93 ? 302 TRP A CE2   1 
ATOM   1312 C CE3   . TRP A 1 328 ? 64.766  99.098  154.719 1.00 130.84 ? 302 TRP A CE3   1 
ATOM   1313 C CZ2   . TRP A 1 328 ? 67.179  100.500 154.243 1.00 127.27 ? 302 TRP A CZ2   1 
ATOM   1314 C CZ3   . TRP A 1 328 ? 64.816  100.473 154.716 1.00 163.59 ? 302 TRP A CZ3   1 
ATOM   1315 C CH2   . TRP A 1 328 ? 65.998  101.161 154.445 1.00 131.54 ? 302 TRP A CH2   1 
ATOM   1316 N N     . ASP A 1 329 ? 66.348  93.687  152.382 1.00 104.45 ? 303 ASP A N     1 
ATOM   1317 C CA    . ASP A 1 329 ? 67.551  93.017  151.914 1.00 129.38 ? 303 ASP A CA    1 
ATOM   1318 C C     . ASP A 1 329 ? 67.500  92.844  150.405 1.00 118.11 ? 303 ASP A C     1 
ATOM   1319 O O     . ASP A 1 329 ? 68.484  93.129  149.724 1.00 95.04  ? 303 ASP A O     1 
ATOM   1320 C CB    . ASP A 1 329 ? 67.762  91.721  152.675 1.00 146.95 ? 303 ASP A CB    1 
ATOM   1321 C CG    . ASP A 1 329 ? 68.320  91.905  154.086 1.00 197.07 ? 303 ASP A CG    1 
ATOM   1322 O OD1   . ASP A 1 329 ? 68.953  92.960  154.345 1.00 187.58 ? 303 ASP A OD1   1 
ATOM   1323 O OD2   . ASP A 1 329 ? 68.103  91.007  154.934 1.00 221.76 ? 303 ASP A OD2   1 
ATOM   1324 N N     . ARG A 1 330 ? 66.327  92.426  149.919 1.00 113.78 ? 304 ARG A N     1 
ATOM   1325 C CA    . ARG A 1 330 ? 66.051  92.416  148.499 1.00 95.86  ? 304 ARG A CA    1 
ATOM   1326 C C     . ARG A 1 330 ? 66.253  93.782  147.906 1.00 83.74  ? 304 ARG A C     1 
ATOM   1327 O O     . ARG A 1 330 ? 66.988  93.914  146.921 1.00 94.01  ? 304 ARG A O     1 
ATOM   1328 C CB    . ARG A 1 330 ? 64.642  92.067  148.024 1.00 81.46  ? 304 ARG A CB    1 
ATOM   1329 C CG    . ARG A 1 330 ? 64.869  90.592  147.737 1.00 99.78  ? 304 ARG A CG    1 
ATOM   1330 C CD    . ARG A 1 330 ? 63.600  89.898  147.501 1.00 96.58  ? 304 ARG A CD    1 
ATOM   1331 N NE    . ARG A 1 330 ? 63.255  89.979  146.097 1.00 87.89  ? 304 ARG A NE    1 
ATOM   1332 C CZ    . ARG A 1 330 ? 62.240  89.293  145.657 1.00 119.99 ? 304 ARG A CZ    1 
ATOM   1333 N NH1   . ARG A 1 330 ? 61.401  88.730  146.539 1.00 99.44  ? 304 ARG A NH1   1 
ATOM   1334 N NH2   . ARG A 1 330 ? 62.089  89.190  144.343 1.00 130.69 ? 304 ARG A NH2   1 
ATOM   1335 N N     . THR A 1 331 ? 65.555  94.770  148.440 1.00 70.87  ? 305 THR A N     1 
ATOM   1336 C CA    . THR A 1 331 ? 65.699  96.035  147.756 1.00 78.28  ? 305 THR A CA    1 
ATOM   1337 C C     . THR A 1 331 ? 67.192  96.357  147.579 1.00 83.33  ? 305 THR A C     1 
ATOM   1338 O O     . THR A 1 331 ? 67.628  96.580  146.440 1.00 73.91  ? 305 THR A O     1 
ATOM   1339 C CB    . THR A 1 331 ? 64.900  97.135  148.420 1.00 72.82  ? 305 THR A CB    1 
ATOM   1340 O OG1   . THR A 1 331 ? 63.521  96.917  148.153 1.00 66.72  ? 305 THR A OG1   1 
ATOM   1341 C CG2   . THR A 1 331 ? 65.185  98.450  147.747 1.00 94.08  ? 305 THR A CG2   1 
ATOM   1342 N N     . PHE A 1 332 ? 68.008  96.287  148.645 1.00 73.70  ? 306 PHE A N     1 
ATOM   1343 C CA    . PHE A 1 332 ? 69.404  96.665  148.488 1.00 66.05  ? 306 PHE A CA    1 
ATOM   1344 C C     . PHE A 1 332 ? 70.166  95.719  147.568 1.00 78.86  ? 306 PHE A C     1 
ATOM   1345 O O     . PHE A 1 332 ? 70.975  96.151  146.743 1.00 68.26  ? 306 PHE A O     1 
ATOM   1346 C CB    . PHE A 1 332 ? 70.131  96.668  149.805 1.00 80.60  ? 306 PHE A CB    1 
ATOM   1347 C CG    . PHE A 1 332 ? 71.628  96.848  149.645 1.00 94.06  ? 306 PHE A CG    1 
ATOM   1348 C CD1   . PHE A 1 332 ? 72.182  98.106  149.431 1.00 88.15  ? 306 PHE A CD1   1 
ATOM   1349 C CD2   . PHE A 1 332 ? 72.474  95.758  149.825 1.00 107.77 ? 306 PHE A CD2   1 
ATOM   1350 C CE1   . PHE A 1 332 ? 73.547  98.235  149.288 1.00 98.04  ? 306 PHE A CE1   1 
ATOM   1351 C CE2   . PHE A 1 332 ? 73.838  95.899  149.709 1.00 102.00 ? 306 PHE A CE2   1 
ATOM   1352 C CZ    . PHE A 1 332 ? 74.363  97.128  149.400 1.00 118.78 ? 306 PHE A CZ    1 
ATOM   1353 N N     . SER A 1 333 ? 69.901  94.416  147.710 1.00 108.57 ? 307 SER A N     1 
ATOM   1354 C CA    . SER A 1 333 ? 70.509  93.420  146.838 1.00 104.54 ? 307 SER A CA    1 
ATOM   1355 C C     . SER A 1 333 ? 70.408  93.887  145.406 1.00 88.85  ? 307 SER A C     1 
ATOM   1356 O O     . SER A 1 333 ? 71.469  93.899  144.759 1.00 73.24  ? 307 SER A O     1 
ATOM   1357 C CB    . SER A 1 333 ? 69.883  92.089  146.978 1.00 143.98 ? 307 SER A CB    1 
ATOM   1358 O OG    . SER A 1 333 ? 69.767  91.756  148.357 1.00 179.99 ? 307 SER A OG    1 
ATOM   1359 N N     . LEU A 1 334 ? 69.156  94.301  145.026 1.00 65.43  ? 308 LEU A N     1 
ATOM   1360 C CA    . LEU A 1 334 ? 68.819  94.803  143.694 1.00 50.99  ? 308 LEU A CA    1 
ATOM   1361 C C     . LEU A 1 334 ? 69.602  96.057  143.377 1.00 48.01  ? 308 LEU A C     1 
ATOM   1362 O O     . LEU A 1 334 ? 70.283  96.143  142.334 1.00 37.69  ? 308 LEU A O     1 
ATOM   1363 C CB    . LEU A 1 334 ? 67.368  95.075  143.396 1.00 53.57  ? 308 LEU A CB    1 
ATOM   1364 C CG    . LEU A 1 334 ? 66.591  93.843  142.971 1.00 70.75  ? 308 LEU A CG    1 
ATOM   1365 C CD1   . LEU A 1 334 ? 65.234  94.092  142.320 1.00 77.88  ? 308 LEU A CD1   1 
ATOM   1366 C CD2   . LEU A 1 334 ? 67.447  93.167  141.987 1.00 78.78  ? 308 LEU A CD2   1 
ATOM   1367 N N     . PHE A 1 335 ? 69.511  97.028  144.279 1.00 50.82  ? 309 PHE A N     1 
ATOM   1368 C CA    . PHE A 1 335 ? 70.164  98.290  143.968 1.00 63.02  ? 309 PHE A CA    1 
ATOM   1369 C C     . PHE A 1 335 ? 71.596  97.988  143.571 1.00 62.88  ? 309 PHE A C     1 
ATOM   1370 O O     . PHE A 1 335 ? 72.056  98.431  142.533 1.00 56.20  ? 309 PHE A O     1 
ATOM   1371 C CB    . PHE A 1 335 ? 70.148  99.278  145.128 1.00 59.67  ? 309 PHE A CB    1 
ATOM   1372 C CG    . PHE A 1 335 ? 70.480  100.694 144.730 1.00 58.91  ? 309 PHE A CG    1 
ATOM   1373 C CD1   . PHE A 1 335 ? 69.646  101.413 143.928 1.00 86.69  ? 309 PHE A CD1   1 
ATOM   1374 C CD2   . PHE A 1 335 ? 71.596  101.309 145.165 1.00 73.73  ? 309 PHE A CD2   1 
ATOM   1375 C CE1   . PHE A 1 335 ? 69.950  102.697 143.532 1.00 89.38  ? 309 PHE A CE1   1 
ATOM   1376 C CE2   . PHE A 1 335 ? 71.827  102.625 144.863 1.00 96.75  ? 309 PHE A CE2   1 
ATOM   1377 C CZ    . PHE A 1 335 ? 71.031  103.308 144.011 1.00 78.41  ? 309 PHE A CZ    1 
ATOM   1378 N N     . GLN A 1 336 ? 72.217  97.136  144.382 1.00 69.04  ? 310 GLN A N     1 
ATOM   1379 C CA    . GLN A 1 336 ? 73.639  96.942  144.295 1.00 80.05  ? 310 GLN A CA    1 
ATOM   1380 C C     . GLN A 1 336 ? 73.992  96.395  142.894 1.00 71.25  ? 310 GLN A C     1 
ATOM   1381 O O     . GLN A 1 336 ? 74.918  96.889  142.215 1.00 50.96  ? 310 GLN A O     1 
ATOM   1382 C CB    . GLN A 1 336 ? 74.074  96.214  145.577 1.00 87.20  ? 310 GLN A CB    1 
ATOM   1383 C CG    . GLN A 1 336 ? 75.591  96.110  145.625 1.00 112.08 ? 310 GLN A CG    1 
ATOM   1384 C CD    . GLN A 1 336 ? 76.179  95.150  146.621 1.00 122.28 ? 310 GLN A CD    1 
ATOM   1385 O OE1   . GLN A 1 336 ? 77.038  95.542  147.418 1.00 161.60 ? 310 GLN A OE1   1 
ATOM   1386 N NE2   . GLN A 1 336 ? 75.829  93.875  146.496 1.00 113.79 ? 310 GLN A NE2   1 
ATOM   1387 N N     . GLN A 1 337 ? 73.251  95.379  142.436 1.00 66.65  ? 311 GLN A N     1 
ATOM   1388 C CA    . GLN A 1 337 ? 73.572  94.760  141.158 1.00 68.89  ? 311 GLN A CA    1 
ATOM   1389 C C     . GLN A 1 337 ? 73.492  95.815  140.083 1.00 58.95  ? 311 GLN A C     1 
ATOM   1390 O O     . GLN A 1 337 ? 74.463  95.990  139.350 1.00 56.88  ? 311 GLN A O     1 
ATOM   1391 C CB    . GLN A 1 337 ? 72.559  93.703  140.777 1.00 85.89  ? 311 GLN A CB    1 
ATOM   1392 C CG    . GLN A 1 337 ? 73.077  92.671  139.798 1.00 106.23 ? 311 GLN A CG    1 
ATOM   1393 C CD    . GLN A 1 337 ? 71.962  91.737  139.359 1.00 169.03 ? 311 GLN A CD    1 
ATOM   1394 O OE1   . GLN A 1 337 ? 70.833  91.757  139.876 1.00 118.45 ? 311 GLN A OE1   1 
ATOM   1395 N NE2   . GLN A 1 337 ? 72.264  90.891  138.383 1.00 225.17 ? 311 GLN A NE2   1 
ATOM   1396 N N     . LEU A 1 338 ? 72.397  96.592  140.175 1.00 57.95  ? 312 LEU A N     1 
ATOM   1397 C CA    . LEU A 1 338 ? 72.069  97.703  139.277 1.00 63.51  ? 312 LEU A CA    1 
ATOM   1398 C C     . LEU A 1 338 ? 73.160  98.728  139.094 1.00 53.91  ? 312 LEU A C     1 
ATOM   1399 O O     . LEU A 1 338 ? 73.434  99.095  137.967 1.00 74.02  ? 312 LEU A O     1 
ATOM   1400 C CB    . LEU A 1 338 ? 70.892  98.580  139.652 1.00 62.58  ? 312 LEU A CB    1 
ATOM   1401 C CG    . LEU A 1 338 ? 70.520  99.530  138.523 1.00 62.06  ? 312 LEU A CG    1 
ATOM   1402 C CD1   . LEU A 1 338 ? 70.597  98.959  137.139 1.00 54.64  ? 312 LEU A CD1   1 
ATOM   1403 C CD2   . LEU A 1 338 ? 69.075  99.838  138.837 1.00 103.86 ? 312 LEU A CD2   1 
ATOM   1404 N N     . ILE A 1 339 ? 73.697  99.249  140.190 1.00 72.78  ? 313 ILE A N     1 
ATOM   1405 C CA    . ILE A 1 339 ? 74.682  100.303 140.077 1.00 71.85  ? 313 ILE A CA    1 
ATOM   1406 C C     . ILE A 1 339 ? 75.993  99.729  139.620 1.00 65.41  ? 313 ILE A C     1 
ATOM   1407 O O     . ILE A 1 339 ? 76.575  100.350 138.722 1.00 56.57  ? 313 ILE A O     1 
ATOM   1408 C CB    . ILE A 1 339 ? 74.886  101.062 141.367 1.00 70.03  ? 313 ILE A CB    1 
ATOM   1409 C CG1   . ILE A 1 339 ? 73.837  102.033 141.485 1.00 83.34  ? 313 ILE A CG1   1 
ATOM   1410 C CG2   . ILE A 1 339 ? 76.221  101.754 141.314 1.00 86.62  ? 313 ILE A CG2   1 
ATOM   1411 C CD1   . ILE A 1 339 ? 73.756  102.539 142.884 1.00 106.29 ? 313 ILE A CD1   1 
ATOM   1412 N N     . GLN A 1 340 ? 76.385  98.588  140.233 1.00 59.30  ? 314 GLN A N     1 
ATOM   1413 C CA    . GLN A 1 340 ? 77.602  97.882  139.842 1.00 67.25  ? 314 GLN A CA    1 
ATOM   1414 C C     . GLN A 1 340 ? 77.723  97.801  138.315 1.00 72.53  ? 314 GLN A C     1 
ATOM   1415 O O     . GLN A 1 340 ? 78.795  98.029  137.709 1.00 51.36  ? 314 GLN A O     1 
ATOM   1416 C CB    . GLN A 1 340 ? 77.712  96.518  140.514 1.00 65.13  ? 314 GLN A CB    1 
ATOM   1417 C CG    . GLN A 1 340 ? 78.225  96.678  141.933 1.00 77.01  ? 314 GLN A CG    1 
ATOM   1418 C CD    . GLN A 1 340 ? 78.240  95.452  142.815 1.00 83.44  ? 314 GLN A CD    1 
ATOM   1419 O OE1   . GLN A 1 340 ? 77.472  94.500  142.665 1.00 111.05 ? 314 GLN A OE1   1 
ATOM   1420 N NE2   . GLN A 1 340 ? 79.064  95.524  143.845 1.00 103.88 ? 314 GLN A NE2   1 
ATOM   1421 N N     . SER A 1 341 ? 76.582  97.520  137.686 1.00 65.43  ? 315 SER A N     1 
ATOM   1422 C CA    . SER A 1 341 ? 76.616  97.195  136.284 1.00 56.83  ? 315 SER A CA    1 
ATOM   1423 C C     . SER A 1 341 ? 76.715  98.448  135.447 1.00 52.96  ? 315 SER A C     1 
ATOM   1424 O O     . SER A 1 341 ? 77.410  98.446  134.437 1.00 63.27  ? 315 SER A O     1 
ATOM   1425 C CB    . SER A 1 341 ? 75.509  96.329  135.948 1.00 60.26  ? 315 SER A CB    1 
ATOM   1426 O OG    . SER A 1 341 ? 75.966  95.000  136.232 1.00 72.27  ? 315 SER A OG    1 
ATOM   1427 N N     . SER A 1 342 ? 76.196  99.540  135.947 1.00 49.51  ? 316 SER A N     1 
ATOM   1428 C CA    . SER A 1 342 ? 76.337  100.768 135.204 1.00 58.85  ? 316 SER A CA    1 
ATOM   1429 C C     . SER A 1 342 ? 77.797  101.201 134.958 1.00 61.36  ? 316 SER A C     1 
ATOM   1430 O O     . SER A 1 342 ? 78.081  101.936 134.032 1.00 58.82  ? 316 SER A O     1 
ATOM   1431 C CB    . SER A 1 342 ? 75.623  101.825 135.940 1.00 70.44  ? 316 SER A CB    1 
ATOM   1432 O OG    . SER A 1 342 ? 75.503  102.993 135.137 1.00 83.61  ? 316 SER A OG    1 
ATOM   1433 N N     . PHE A 1 343 ? 78.773  100.890 135.797 1.00 58.58  ? 317 PHE A N     1 
ATOM   1434 C CA    . PHE A 1 343 ? 80.042  101.583 135.617 1.00 57.22  ? 317 PHE A CA    1 
ATOM   1435 C C     . PHE A 1 343 ? 80.769  100.979 134.405 1.00 55.23  ? 317 PHE A C     1 
ATOM   1436 O O     . PHE A 1 343 ? 81.101  99.810  134.448 1.00 87.92  ? 317 PHE A O     1 
ATOM   1437 C CB    . PHE A 1 343 ? 80.667  101.431 137.012 1.00 62.73  ? 317 PHE A CB    1 
ATOM   1438 C CG    . PHE A 1 343 ? 82.049  102.038 137.215 1.00 70.40  ? 317 PHE A CG    1 
ATOM   1439 C CD1   . PHE A 1 343 ? 82.221  103.383 136.986 1.00 83.09  ? 317 PHE A CD1   1 
ATOM   1440 C CD2   . PHE A 1 343 ? 83.164  101.278 137.575 1.00 70.53  ? 317 PHE A CD2   1 
ATOM   1441 C CE1   . PHE A 1 343 ? 83.452  103.982 137.128 1.00 60.20  ? 317 PHE A CE1   1 
ATOM   1442 C CE2   . PHE A 1 343 ? 84.394  101.867 137.717 1.00 75.52  ? 317 PHE A CE2   1 
ATOM   1443 C CZ    . PHE A 1 343 ? 84.518  103.237 137.498 1.00 77.56  ? 317 PHE A CZ    1 
ATOM   1444 N N     . VAL A 1 344 ? 81.049  101.743 133.350 1.00 45.34  ? 318 VAL A N     1 
ATOM   1445 C CA    . VAL A 1 344 ? 81.395  101.199 132.050 1.00 47.40  ? 318 VAL A CA    1 
ATOM   1446 C C     . VAL A 1 344 ? 82.354  102.102 131.283 1.00 52.06  ? 318 VAL A C     1 
ATOM   1447 O O     . VAL A 1 344 ? 82.123  103.313 131.227 1.00 66.22  ? 318 VAL A O     1 
ATOM   1448 C CB    . VAL A 1 344 ? 80.140  100.971 131.147 1.00 53.39  ? 318 VAL A CB    1 
ATOM   1449 C CG1   . VAL A 1 344 ? 79.038  100.244 131.870 1.00 65.51  ? 318 VAL A CG1   1 
ATOM   1450 C CG2   . VAL A 1 344 ? 79.492  102.163 130.495 1.00 36.90  ? 318 VAL A CG2   1 
ATOM   1451 N N     . VAL A 1 345 ? 83.268  101.514 130.485 1.00 51.42  ? 319 VAL A N     1 
ATOM   1452 C CA    . VAL A 1 345 ? 84.297  102.287 129.773 1.00 43.59  ? 319 VAL A CA    1 
ATOM   1453 C C     . VAL A 1 345 ? 83.698  102.826 128.492 1.00 43.50  ? 319 VAL A C     1 
ATOM   1454 O O     . VAL A 1 345 ? 83.516  102.083 127.563 1.00 47.32  ? 319 VAL A O     1 
ATOM   1455 C CB    . VAL A 1 345 ? 85.540  101.427 129.444 1.00 58.05  ? 319 VAL A CB    1 
ATOM   1456 C CG1   . VAL A 1 345 ? 86.564  102.146 128.572 1.00 66.08  ? 319 VAL A CG1   1 
ATOM   1457 C CG2   . VAL A 1 345 ? 86.259  100.794 130.646 1.00 52.18  ? 319 VAL A CG2   1 
ATOM   1458 N N     . GLU A 1 346 ? 83.284  104.084 128.479 1.00 65.03  ? 320 GLU A N     1 
ATOM   1459 C CA    . GLU A 1 346 ? 82.521  104.624 127.364 1.00 63.35  ? 320 GLU A CA    1 
ATOM   1460 C C     . GLU A 1 346 ? 83.401  104.762 126.145 1.00 60.71  ? 320 GLU A C     1 
ATOM   1461 O O     . GLU A 1 346 ? 82.847  104.743 125.052 1.00 78.65  ? 320 GLU A O     1 
ATOM   1462 C CB    . GLU A 1 346 ? 81.959  106.007 127.682 1.00 78.54  ? 320 GLU A CB    1 
ATOM   1463 C CG    . GLU A 1 346 ? 81.487  106.833 126.486 1.00 109.05 ? 320 GLU A CG    1 
ATOM   1464 C CD    . GLU A 1 346 ? 80.689  108.105 126.828 1.00 154.04 ? 320 GLU A CD    1 
ATOM   1465 O OE1   . GLU A 1 346 ? 80.275  108.380 127.995 1.00 106.02 ? 320 GLU A OE1   1 
ATOM   1466 O OE2   . GLU A 1 346 ? 80.472  108.869 125.858 1.00 195.34 ? 320 GLU A OE2   1 
ATOM   1467 N N     . ARG A 1 347 ? 84.723  104.967 126.325 1.00 64.11  ? 321 ARG A N     1 
ATOM   1468 C CA    . ARG A 1 347 ? 85.649  105.066 125.200 1.00 70.66  ? 321 ARG A CA    1 
ATOM   1469 C C     . ARG A 1 347 ? 86.953  104.426 125.576 1.00 75.36  ? 321 ARG A C     1 
ATOM   1470 O O     . ARG A 1 347 ? 87.559  104.984 126.485 1.00 78.67  ? 321 ARG A O     1 
ATOM   1471 C CB    . ARG A 1 347 ? 86.195  106.463 124.923 1.00 74.57  ? 321 ARG A CB    1 
ATOM   1472 C CG    . ARG A 1 347 ? 85.787  107.047 123.576 1.00 114.19 ? 321 ARG A CG    1 
ATOM   1473 C CD    . ARG A 1 347 ? 86.162  108.555 123.323 1.00 129.37 ? 321 ARG A CD    1 
ATOM   1474 N NE    . ARG A 1 347 ? 87.608  108.804 123.367 1.00 102.96 ? 321 ARG A NE    1 
ATOM   1475 C CZ    . ARG A 1 347 ? 88.255  109.387 124.382 1.00 121.88 ? 321 ARG A CZ    1 
ATOM   1476 N NH1   . ARG A 1 347 ? 87.648  110.245 125.196 1.00 109.61 ? 321 ARG A NH1   1 
ATOM   1477 N NH2   . ARG A 1 347 ? 89.543  109.133 124.545 1.00 132.72 ? 321 ARG A NH2   1 
ATOM   1478 N N     . GLN A 1 348 ? 87.408  103.373 124.858 1.00 67.18  ? 322 GLN A N     1 
ATOM   1479 C CA    . GLN A 1 348 ? 88.527  102.578 125.369 1.00 56.92  ? 322 GLN A CA    1 
ATOM   1480 C C     . GLN A 1 348 ? 89.860  103.268 125.034 1.00 62.40  ? 322 GLN A C     1 
ATOM   1481 O O     . GLN A 1 348 ? 89.897  104.141 124.166 1.00 77.15  ? 322 GLN A O     1 
ATOM   1482 C CB    . GLN A 1 348 ? 88.639  101.217 124.718 1.00 57.56  ? 322 GLN A CB    1 
ATOM   1483 C CG    . GLN A 1 348 ? 87.341  100.457 124.586 1.00 52.85  ? 322 GLN A CG    1 
ATOM   1484 C CD    . GLN A 1 348 ? 87.134  99.578  125.777 1.00 49.47  ? 322 GLN A CD    1 
ATOM   1485 O OE1   . GLN A 1 348 ? 88.009  98.850  126.255 1.00 59.94  ? 322 GLN A OE1   1 
ATOM   1486 N NE2   . GLN A 1 348 ? 85.915  99.608  126.252 1.00 71.20  ? 322 GLN A NE2   1 
ATOM   1487 N N     . PRO A 1 349 ? 90.995  102.879 125.655 1.00 49.58  ? 323 PRO A N     1 
ATOM   1488 C CA    . PRO A 1 349 ? 92.233  103.633 125.602 1.00 51.94  ? 323 PRO A CA    1 
ATOM   1489 C C     . PRO A 1 349 ? 92.874  103.767 124.234 1.00 63.14  ? 323 PRO A C     1 
ATOM   1490 O O     . PRO A 1 349 ? 92.893  102.787 123.457 1.00 53.87  ? 323 PRO A O     1 
ATOM   1491 C CB    . PRO A 1 349 ? 93.138  102.717 126.450 1.00 59.02  ? 323 PRO A CB    1 
ATOM   1492 C CG    . PRO A 1 349 ? 92.242  102.076 127.438 1.00 58.20  ? 323 PRO A CG    1 
ATOM   1493 C CD    . PRO A 1 349 ? 91.172  101.662 126.444 1.00 59.21  ? 323 PRO A CD    1 
ATOM   1494 N N     . CYS A 1 350 ? 93.530  104.930 124.042 1.00 61.03  ? 324 CYS A N     1 
ATOM   1495 C CA    . CYS A 1 350 ? 93.955  105.330 122.710 1.00 69.02  ? 324 CYS A CA    1 
ATOM   1496 C C     . CYS A 1 350 ? 95.026  106.435 122.713 1.00 72.52  ? 324 CYS A C     1 
ATOM   1497 O O     . CYS A 1 350 ? 94.943  107.453 123.421 1.00 55.39  ? 324 CYS A O     1 
ATOM   1498 C CB    . CYS A 1 350 ? 92.712  105.785 121.953 1.00 72.31  ? 324 CYS A CB    1 
ATOM   1499 S SG    . CYS A 1 350 ? 92.859  105.539 120.177 1.00 83.62  ? 324 CYS A SG    1 
ATOM   1500 N N     . MET A 1 351 ? 96.013  106.290 121.823 1.00 64.05  ? 325 MET A N     1 
ATOM   1501 C CA    . MET A 1 351 ? 96.911  107.413 121.628 1.00 65.67  ? 325 MET A CA    1 
ATOM   1502 C C     . MET A 1 351 ? 96.340  108.402 120.611 1.00 74.85  ? 325 MET A C     1 
ATOM   1503 O O     . MET A 1 351 ? 96.155  108.014 119.456 1.00 74.16  ? 325 MET A O     1 
ATOM   1504 C CB    . MET A 1 351 ? 98.250  106.888 121.132 1.00 64.21  ? 325 MET A CB    1 
ATOM   1505 C CG    . MET A 1 351 ? 99.037  106.218 122.226 1.00 74.88  ? 325 MET A CG    1 
ATOM   1506 S SD    . MET A 1 351 ? 100.572 105.509 121.606 1.00 79.83  ? 325 MET A SD    1 
ATOM   1507 C CE    . MET A 1 351 ? 100.208 104.889 119.945 1.00 79.87  ? 325 MET A CE    1 
ATOM   1508 N N     . PRO A 1 352 ? 96.103  109.695 120.957 1.00 69.56  ? 326 PRO A N     1 
ATOM   1509 C CA    . PRO A 1 352 ? 95.520  110.700 120.039 1.00 80.91  ? 326 PRO A CA    1 
ATOM   1510 C C     . PRO A 1 352 ? 96.107  110.808 118.634 1.00 83.16  ? 326 PRO A C     1 
ATOM   1511 O O     . PRO A 1 352 ? 95.431  110.956 117.609 1.00 72.55  ? 326 PRO A O     1 
ATOM   1512 C CB    . PRO A 1 352 ? 95.766  111.998 120.769 1.00 73.17  ? 326 PRO A CB    1 
ATOM   1513 C CG    . PRO A 1 352 ? 95.676  111.584 122.214 1.00 83.94  ? 326 PRO A CG    1 
ATOM   1514 C CD    . PRO A 1 352 ? 96.365  110.240 122.277 1.00 77.63  ? 326 PRO A CD    1 
ATOM   1515 N N     . THR A 1 353 ? 97.421  110.714 118.632 1.00 79.06  ? 327 THR A N     1 
ATOM   1516 C CA    . THR A 1 353 ? 98.188  110.660 117.413 1.00 75.20  ? 327 THR A CA    1 
ATOM   1517 C C     . THR A 1 353 ? 97.996  109.323 116.697 1.00 65.21  ? 327 THR A C     1 
ATOM   1518 O O     . THR A 1 353 ? 98.722  109.034 115.745 1.00 78.73  ? 327 THR A O     1 
ATOM   1519 C CB    . THR A 1 353 ? 99.634  110.902 117.849 1.00 102.30 ? 327 THR A CB    1 
ATOM   1520 O OG1   . THR A 1 353 ? 100.511 110.672 116.744 1.00 132.48 ? 327 THR A OG1   1 
ATOM   1521 C CG2   . THR A 1 353 ? 100.036 110.007 119.015 1.00 110.50 ? 327 THR A CG2   1 
ATOM   1522 N N     . HIS A 1 354 ? 97.085  108.463 117.164 1.00 63.08  ? 328 HIS A N     1 
ATOM   1523 C CA    . HIS A 1 354 ? 96.854  107.208 116.463 1.00 80.64  ? 328 HIS A CA    1 
ATOM   1524 C C     . HIS A 1 354 ? 95.419  106.737 116.651 1.00 94.05  ? 328 HIS A C     1 
ATOM   1525 O O     . HIS A 1 354 ? 95.156  105.688 117.232 1.00 121.25 ? 328 HIS A O     1 
ATOM   1526 C CB    . HIS A 1 354 ? 97.744  106.072 116.968 1.00 82.97  ? 328 HIS A CB    1 
ATOM   1527 C CG    . HIS A 1 354 ? 99.153  106.168 116.589 1.00 80.55  ? 328 HIS A CG    1 
ATOM   1528 N ND1   . HIS A 1 354 ? 99.503  105.855 115.302 1.00 96.67  ? 328 HIS A ND1   1 
ATOM   1529 C CD2   . HIS A 1 354 ? 100.244 106.551 117.226 1.00 66.44  ? 328 HIS A CD2   1 
ATOM   1530 C CE1   . HIS A 1 354 ? 100.799 106.031 115.192 1.00 93.51  ? 328 HIS A CE1   1 
ATOM   1531 N NE2   . HIS A 1 354 ? 101.257 106.434 116.348 1.00 72.98  ? 328 HIS A NE2   1 
ATOM   1532 N N     . PRO A 1 355 ? 94.440  107.444 116.084 1.00 79.35  ? 329 PRO A N     1 
ATOM   1533 C CA    . PRO A 1 355 ? 93.069  107.311 116.548 1.00 79.44  ? 329 PRO A CA    1 
ATOM   1534 C C     . PRO A 1 355 ? 92.307  106.152 115.918 1.00 67.24  ? 329 PRO A C     1 
ATOM   1535 O O     . PRO A 1 355 ? 91.339  105.656 116.484 1.00 78.53  ? 329 PRO A O     1 
ATOM   1536 C CB    . PRO A 1 355 ? 92.495  108.647 116.238 1.00 80.68  ? 329 PRO A CB    1 
ATOM   1537 C CG    . PRO A 1 355 ? 93.404  109.188 115.157 1.00 93.89  ? 329 PRO A CG    1 
ATOM   1538 C CD    . PRO A 1 355 ? 94.612  108.330 114.951 1.00 74.86  ? 329 PRO A CD    1 
ATOM   1539 N N     . GLN A 1 356 ? 92.809  105.609 114.830 1.00 59.86  ? 330 GLN A N     1 
ATOM   1540 C CA    . GLN A 1 356 ? 92.185  104.394 114.345 1.00 69.82  ? 330 GLN A CA    1 
ATOM   1541 C C     . GLN A 1 356 ? 92.880  103.162 114.929 1.00 65.04  ? 330 GLN A C     1 
ATOM   1542 O O     . GLN A 1 356 ? 92.906  102.075 114.328 1.00 63.69  ? 330 GLN A O     1 
ATOM   1543 C CB    . GLN A 1 356 ? 92.280  104.273 112.818 1.00 91.13  ? 330 GLN A CB    1 
ATOM   1544 C CG    . GLN A 1 356 ? 91.797  105.486 112.041 1.00 83.03  ? 330 GLN A CG    1 
ATOM   1545 C CD    . GLN A 1 356 ? 90.574  106.047 112.701 1.00 95.49  ? 330 GLN A CD    1 
ATOM   1546 O OE1   . GLN A 1 356 ? 89.579  105.332 112.872 1.00 108.47 ? 330 GLN A OE1   1 
ATOM   1547 N NE2   . GLN A 1 356 ? 90.676  107.292 113.160 1.00 117.58 ? 330 GLN A NE2   1 
ATOM   1548 N N     . ARG A 1 357 ? 93.544  103.315 116.055 1.00 52.92  ? 331 ARG A N     1 
ATOM   1549 C CA    . ARG A 1 357 ? 94.355  102.191 116.425 1.00 47.85  ? 331 ARG A CA    1 
ATOM   1550 C C     . ARG A 1 357 ? 94.232  102.138 117.910 1.00 55.25  ? 331 ARG A C     1 
ATOM   1551 O O     . ARG A 1 357 ? 95.151  102.501 118.625 1.00 77.70  ? 331 ARG A O     1 
ATOM   1552 C CB    . ARG A 1 357 ? 95.768  102.338 115.876 1.00 47.75  ? 331 ARG A CB    1 
ATOM   1553 C CG    . ARG A 1 357 ? 96.123  101.135 115.016 1.00 52.23  ? 331 ARG A CG    1 
ATOM   1554 C CD    . ARG A 1 357 ? 95.448  101.189 113.728 1.00 56.96  ? 331 ARG A CD    1 
ATOM   1555 N NE    . ARG A 1 357 ? 96.179  100.455 112.699 1.00 73.35  ? 331 ARG A NE    1 
ATOM   1556 C CZ    . ARG A 1 357 ? 95.594  100.316 111.519 1.00 106.41 ? 331 ARG A CZ    1 
ATOM   1557 N NH1   . ARG A 1 357 ? 94.310  100.626 111.365 1.00 100.56 ? 331 ARG A NH1   1 
ATOM   1558 N NH2   . ARG A 1 357 ? 96.279  99.867  110.491 1.00 120.35 ? 331 ARG A NH2   1 
ATOM   1559 N N     . PRO A 1 358 ? 93.029  101.820 118.385 1.00 55.56  ? 332 PRO A N     1 
ATOM   1560 C CA    . PRO A 1 358 ? 92.692  102.050 119.761 1.00 60.46  ? 332 PRO A CA    1 
ATOM   1561 C C     . PRO A 1 358 ? 92.717  100.770 120.533 1.00 61.87  ? 332 PRO A C     1 
ATOM   1562 O O     . PRO A 1 358 ? 91.671  100.360 120.993 1.00 89.60  ? 332 PRO A O     1 
ATOM   1563 C CB    . PRO A 1 358 ? 91.316  102.555 119.523 1.00 65.39  ? 332 PRO A CB    1 
ATOM   1564 C CG    . PRO A 1 358 ? 90.735  101.574 118.574 1.00 60.90  ? 332 PRO A CG    1 
ATOM   1565 C CD    . PRO A 1 358 ? 91.881  101.369 117.621 1.00 60.67  ? 332 PRO A CD    1 
ATOM   1566 N N     . LEU A 1 359 ? 93.882  100.177 120.699 1.00 52.93  ? 333 LEU A N     1 
ATOM   1567 C CA    . LEU A 1 359 ? 94.055  99.380  121.901 1.00 63.75  ? 333 LEU A CA    1 
ATOM   1568 C C     . LEU A 1 359 ? 95.522  99.033  122.018 1.00 70.75  ? 333 LEU A C     1 
ATOM   1569 O O     . LEU A 1 359 ? 95.905  97.987  122.565 1.00 62.66  ? 333 LEU A O     1 
ATOM   1570 C CB    . LEU A 1 359 ? 93.211  98.096  121.841 1.00 70.42  ? 333 LEU A CB    1 
ATOM   1571 C CG    . LEU A 1 359 ? 91.723  98.221  122.207 1.00 71.49  ? 333 LEU A CG    1 
ATOM   1572 C CD1   . LEU A 1 359 ? 90.908  96.952  122.089 1.00 80.45  ? 333 LEU A CD1   1 
ATOM   1573 C CD2   . LEU A 1 359 ? 91.549  98.789  123.599 1.00 65.63  ? 333 LEU A CD2   1 
ATOM   1574 N N     . VAL A 1 360 ? 96.326  99.908  121.418 1.00 65.95  ? 334 VAL A N     1 
ATOM   1575 C CA    . VAL A 1 360 ? 97.771  99.774  121.444 1.00 56.98  ? 334 VAL A CA    1 
ATOM   1576 C C     . VAL A 1 360 ? 98.342  101.087 121.957 1.00 49.72  ? 334 VAL A C     1 
ATOM   1577 O O     . VAL A 1 360 ? 97.912  102.161 121.544 1.00 59.35  ? 334 VAL A O     1 
ATOM   1578 C CB    . VAL A 1 360 ? 98.327  99.513  120.056 1.00 59.40  ? 334 VAL A CB    1 
ATOM   1579 C CG1   . VAL A 1 360 ? 99.823  99.502  120.140 1.00 66.89  ? 334 VAL A CG1   1 
ATOM   1580 C CG2   . VAL A 1 360 ? 97.775  98.238  119.472 1.00 60.87  ? 334 VAL A CG2   1 
ATOM   1581 N N     . LEU A 1 361 ? 99.281  100.966 122.875 1.00 50.00  ? 335 LEU A N     1 
ATOM   1582 C CA    . LEU A 1 361 ? 99.842  102.057 123.642 1.00 47.93  ? 335 LEU A CA    1 
ATOM   1583 C C     . LEU A 1 361 ? 101.360 102.066 123.440 1.00 64.65  ? 335 LEU A C     1 
ATOM   1584 O O     . LEU A 1 361 ? 101.992 101.044 123.165 1.00 76.75  ? 335 LEU A O     1 
ATOM   1585 C CB    . LEU A 1 361 ? 99.421  101.554 125.020 1.00 52.66  ? 335 LEU A CB    1 
ATOM   1586 C CG    . LEU A 1 361 ? 97.946  101.728 125.398 1.00 54.87  ? 335 LEU A CG    1 
ATOM   1587 C CD1   . LEU A 1 361 ? 97.664  101.829 126.937 1.00 71.44  ? 335 LEU A CD1   1 
ATOM   1588 C CD2   . LEU A 1 361 ? 97.489  103.017 124.796 1.00 49.83  ? 335 LEU A CD2   1 
ATOM   1589 N N     . LYS A 1 362 ? 102.007 103.210 123.588 1.00 75.33  ? 336 LYS A N     1 
ATOM   1590 C CA    . LYS A 1 362 ? 103.465 103.193 123.586 1.00 66.99  ? 336 LYS A CA    1 
ATOM   1591 C C     . LYS A 1 362 ? 103.997 103.885 124.843 1.00 71.20  ? 336 LYS A C     1 
ATOM   1592 O O     . LYS A 1 362 ? 103.541 104.962 125.234 1.00 82.80  ? 336 LYS A O     1 
ATOM   1593 C CB    . LYS A 1 362 ? 103.940 103.730 122.243 1.00 65.52  ? 336 LYS A CB    1 
ATOM   1594 C CG    . LYS A 1 362 ? 105.180 104.586 122.265 1.00 76.08  ? 336 LYS A CG    1 
ATOM   1595 C CD    . LYS A 1 362 ? 105.781 104.594 120.861 1.00 99.70  ? 336 LYS A CD    1 
ATOM   1596 C CE    . LYS A 1 362 ? 106.556 105.841 120.521 1.00 129.22 ? 336 LYS A CE    1 
ATOM   1597 N NZ    . LYS A 1 362 ? 107.483 105.663 119.385 1.00 134.97 ? 336 LYS A NZ    1 
ATOM   1598 N N     . THR A 1 363 ? 104.885 103.172 125.550 1.00 82.08  ? 337 THR A N     1 
ATOM   1599 C CA    . THR A 1 363 ? 105.630 103.705 126.679 1.00 69.80  ? 337 THR A CA    1 
ATOM   1600 C C     . THR A 1 363 ? 106.081 105.084 126.241 1.00 75.55  ? 337 THR A C     1 
ATOM   1601 O O     . THR A 1 363 ? 106.833 105.190 125.262 1.00 102.42 ? 337 THR A O     1 
ATOM   1602 C CB    . THR A 1 363 ? 106.834 102.802 126.951 1.00 89.61  ? 337 THR A CB    1 
ATOM   1603 O OG1   . THR A 1 363 ? 107.687 102.687 125.805 1.00 91.16  ? 337 THR A OG1   1 
ATOM   1604 C CG2   . THR A 1 363 ? 106.434 101.370 127.238 1.00 102.17 ? 337 THR A CG2   1 
ATOM   1605 N N     . GLY A 1 364 ? 105.541 106.133 126.864 1.00 72.05  ? 338 GLY A N     1 
ATOM   1606 C CA    . GLY A 1 364 ? 106.070 107.469 126.624 1.00 82.79  ? 338 GLY A CA    1 
ATOM   1607 C C     . GLY A 1 364 ? 105.006 108.460 126.181 1.00 85.53  ? 338 GLY A C     1 
ATOM   1608 O O     . GLY A 1 364 ? 104.815 109.526 126.776 1.00 93.40  ? 338 GLY A O     1 
ATOM   1609 N N     . VAL A 1 365 ? 104.288 108.074 125.140 1.00 78.45  ? 339 VAL A N     1 
ATOM   1610 C CA    . VAL A 1 365 ? 103.199 108.891 124.649 1.00 55.75  ? 339 VAL A CA    1 
ATOM   1611 C C     . VAL A 1 365 ? 102.087 108.899 125.683 1.00 58.07  ? 339 VAL A C     1 
ATOM   1612 O O     . VAL A 1 365 ? 101.933 107.945 126.466 1.00 60.26  ? 339 VAL A O     1 
ATOM   1613 C CB    . VAL A 1 365 ? 102.783 108.289 123.304 1.00 52.82  ? 339 VAL A CB    1 
ATOM   1614 C CG1   . VAL A 1 365 ? 101.734 109.116 122.619 1.00 81.97  ? 339 VAL A CG1   1 
ATOM   1615 C CG2   . VAL A 1 365 ? 103.958 108.174 122.344 1.00 76.22  ? 339 VAL A CG2   1 
ATOM   1616 N N     . GLN A 1 366 ? 101.360 110.017 125.659 1.00 67.30  ? 340 GLN A N     1 
ATOM   1617 C CA    . GLN A 1 366 ? 100.144 110.205 126.419 1.00 78.14  ? 340 GLN A CA    1 
ATOM   1618 C C     . GLN A 1 366 ? 98.963  109.581 125.689 1.00 84.77  ? 340 GLN A C     1 
ATOM   1619 O O     . GLN A 1 366 ? 98.955  109.600 124.458 1.00 89.82  ? 340 GLN A O     1 
ATOM   1620 C CB    . GLN A 1 366 ? 99.960  111.709 126.560 1.00 112.21 ? 340 GLN A CB    1 
ATOM   1621 C CG    . GLN A 1 366 ? 100.865 112.276 127.642 1.00 157.63 ? 340 GLN A CG    1 
ATOM   1622 C CD    . GLN A 1 366 ? 100.945 113.780 127.612 1.00 189.87 ? 340 GLN A CD    1 
ATOM   1623 O OE1   . GLN A 1 366 ? 100.079 114.483 128.147 1.00 190.07 ? 340 GLN A OE1   1 
ATOM   1624 N NE2   . GLN A 1 366 ? 102.007 114.281 126.997 1.00 213.55 ? 340 GLN A NE2   1 
ATOM   1625 N N     . PHE A 1 367 ? 97.976  109.074 126.466 1.00 75.19  ? 341 PHE A N     1 
ATOM   1626 C CA    . PHE A 1 367 ? 96.748  108.504 125.939 1.00 64.12  ? 341 PHE A CA    1 
ATOM   1627 C C     . PHE A 1 367 ? 95.595  108.751 126.892 1.00 75.39  ? 341 PHE A C     1 
ATOM   1628 O O     . PHE A 1 367 ? 95.826  108.926 128.083 1.00 83.61  ? 341 PHE A O     1 
ATOM   1629 C CB    . PHE A 1 367 ? 96.829  106.990 125.800 1.00 64.66  ? 341 PHE A CB    1 
ATOM   1630 C CG    . PHE A 1 367 ? 96.912  106.215 127.109 1.00 75.93  ? 341 PHE A CG    1 
ATOM   1631 C CD1   . PHE A 1 367 ? 95.783  105.864 127.830 1.00 69.69  ? 341 PHE A CD1   1 
ATOM   1632 C CD2   . PHE A 1 367 ? 98.135  105.754 127.575 1.00 83.69  ? 341 PHE A CD2   1 
ATOM   1633 C CE1   . PHE A 1 367 ? 95.914  105.102 128.979 1.00 81.44  ? 341 PHE A CE1   1 
ATOM   1634 C CE2   . PHE A 1 367 ? 98.241  104.963 128.706 1.00 66.24  ? 341 PHE A CE2   1 
ATOM   1635 C CZ    . PHE A 1 367 ? 97.136  104.638 129.401 1.00 74.61  ? 341 PHE A CZ    1 
ATOM   1636 N N     . THR A 1 368 ? 94.373  108.563 126.361 1.00 91.22  ? 342 THR A N     1 
ATOM   1637 C CA    . THR A 1 368 ? 93.106  108.994 126.948 1.00 78.29  ? 342 THR A CA    1 
ATOM   1638 C C     . THR A 1 368 ? 92.125  107.817 127.151 1.00 84.00  ? 342 THR A C     1 
ATOM   1639 O O     . THR A 1 368 ? 92.083  106.839 126.371 1.00 73.05  ? 342 THR A O     1 
ATOM   1640 C CB    . THR A 1 368 ? 92.584  110.026 125.954 1.00 90.74  ? 342 THR A CB    1 
ATOM   1641 O OG1   . THR A 1 368 ? 92.512  109.473 124.640 1.00 103.85 ? 342 THR A OG1   1 
ATOM   1642 C CG2   . THR A 1 368 ? 93.582  111.139 125.726 1.00 143.21 ? 342 THR A CG2   1 
ATOM   1643 N N     . VAL A 1 369 ? 91.315  107.922 128.219 1.00 65.93  ? 343 VAL A N     1 
ATOM   1644 C CA    . VAL A 1 369 ? 90.257  106.962 128.507 1.00 66.53  ? 343 VAL A CA    1 
ATOM   1645 C C     . VAL A 1 369 ? 89.037  107.775 128.898 1.00 68.40  ? 343 VAL A C     1 
ATOM   1646 O O     . VAL A 1 369 ? 89.206  108.893 129.352 1.00 118.75 ? 343 VAL A O     1 
ATOM   1647 C CB    . VAL A 1 369 ? 90.608  105.949 129.613 1.00 68.35  ? 343 VAL A CB    1 
ATOM   1648 C CG1   . VAL A 1 369 ? 89.726  104.730 129.563 1.00 70.93  ? 343 VAL A CG1   1 
ATOM   1649 C CG2   . VAL A 1 369 ? 91.981  105.355 129.436 1.00 77.90  ? 343 VAL A CG2   1 
ATOM   1650 N N     . LYS A 1 370 ? 87.820  107.274 128.672 1.00 65.76  ? 344 LYS A N     1 
ATOM   1651 C CA    . LYS A 1 370 ? 86.660  107.853 129.331 1.00 61.94  ? 344 LYS A CA    1 
ATOM   1652 C C     . LYS A 1 370 ? 85.794  106.821 130.059 1.00 66.18  ? 344 LYS A C     1 
ATOM   1653 O O     . LYS A 1 370 ? 85.279  105.876 129.477 1.00 80.24  ? 344 LYS A O     1 
ATOM   1654 C CB    . LYS A 1 370 ? 85.834  108.580 128.289 1.00 59.57  ? 344 LYS A CB    1 
ATOM   1655 C CG    . LYS A 1 370 ? 84.718  109.419 128.887 1.00 61.09  ? 344 LYS A CG    1 
ATOM   1656 C CD    . LYS A 1 370 ? 84.391  110.509 127.861 1.00 76.85  ? 344 LYS A CD    1 
ATOM   1657 C CE    . LYS A 1 370 ? 83.050  111.202 128.015 1.00 110.11 ? 344 LYS A CE    1 
ATOM   1658 N NZ    . LYS A 1 370 ? 82.980  112.592 127.535 1.00 116.86 ? 344 LYS A NZ    1 
ATOM   1659 N N     . LEU A 1 371 ? 85.594  107.019 131.349 1.00 61.88  ? 345 LEU A N     1 
ATOM   1660 C CA    . LEU A 1 371 ? 84.648  106.189 132.048 1.00 62.92  ? 345 LEU A CA    1 
ATOM   1661 C C     . LEU A 1 371 ? 83.310  106.835 131.923 1.00 57.59  ? 345 LEU A C     1 
ATOM   1662 O O     . LEU A 1 371 ? 83.289  107.847 131.237 1.00 73.95  ? 345 LEU A O     1 
ATOM   1663 C CB    . LEU A 1 371 ? 85.076  105.944 133.480 1.00 71.57  ? 345 LEU A CB    1 
ATOM   1664 C CG    . LEU A 1 371 ? 86.080  104.791 133.443 1.00 86.16  ? 345 LEU A CG    1 
ATOM   1665 C CD1   . LEU A 1 371 ? 87.397  105.274 132.908 1.00 74.02  ? 345 LEU A CD1   1 
ATOM   1666 C CD2   . LEU A 1 371 ? 86.190  103.993 134.702 1.00 92.65  ? 345 LEU A CD2   1 
ATOM   1667 N N     . ARG A 1 372 ? 82.244  106.176 132.425 1.00 60.19  ? 346 ARG A N     1 
ATOM   1668 C CA    . ARG A 1 372 ? 80.903  106.764 132.524 1.00 62.96  ? 346 ARG A CA    1 
ATOM   1669 C C     . ARG A 1 372 ? 79.973  105.937 133.373 1.00 58.97  ? 346 ARG A C     1 
ATOM   1670 O O     . ARG A 1 372 ? 79.891  104.739 133.177 1.00 100.93 ? 346 ARG A O     1 
ATOM   1671 C CB    . ARG A 1 372 ? 80.040  106.674 131.284 1.00 56.02  ? 346 ARG A CB    1 
ATOM   1672 C CG    . ARG A 1 372 ? 78.635  107.191 131.492 1.00 60.56  ? 346 ARG A CG    1 
ATOM   1673 C CD    . ARG A 1 372 ? 78.391  107.850 130.127 1.00 77.33  ? 346 ARG A CD    1 
ATOM   1674 N NE    . ARG A 1 372 ? 77.041  108.377 129.928 1.00 71.95  ? 346 ARG A NE    1 
ATOM   1675 C CZ    . ARG A 1 372 ? 76.585  108.741 128.758 1.00 79.35  ? 346 ARG A CZ    1 
ATOM   1676 N NH1   . ARG A 1 372 ? 77.379  108.633 127.705 1.00 89.03  ? 346 ARG A NH1   1 
ATOM   1677 N NH2   . ARG A 1 372 ? 75.331  109.164 128.643 1.00 80.77  ? 346 ARG A NH2   1 
ATOM   1678 N N     . LEU A 1 373 ? 79.223  106.562 134.254 1.00 65.77  ? 347 LEU A N     1 
ATOM   1679 C CA    . LEU A 1 373 ? 78.195  105.832 134.978 1.00 77.58  ? 347 LEU A CA    1 
ATOM   1680 C C     . LEU A 1 373 ? 76.842  106.045 134.302 1.00 76.63  ? 347 LEU A C     1 
ATOM   1681 O O     . LEU A 1 373 ? 76.639  107.032 133.606 1.00 81.29  ? 347 LEU A O     1 
ATOM   1682 C CB    . LEU A 1 373 ? 78.224  106.417 136.372 1.00 79.91  ? 347 LEU A CB    1 
ATOM   1683 C CG    . LEU A 1 373 ? 77.679  105.545 137.483 1.00 74.76  ? 347 LEU A CG    1 
ATOM   1684 C CD1   . LEU A 1 373 ? 78.828  104.540 137.525 1.00 88.19  ? 347 LEU A CD1   1 
ATOM   1685 C CD2   . LEU A 1 373 ? 77.444  106.319 138.799 1.00 63.39  ? 347 LEU A CD2   1 
ATOM   1686 N N     . LEU A 1 374 ? 75.937  105.087 134.425 1.00 69.13  ? 348 LEU A N     1 
ATOM   1687 C CA    . LEU A 1 374 ? 74.724  105.178 133.636 1.00 67.35  ? 348 LEU A CA    1 
ATOM   1688 C C     . LEU A 1 374 ? 73.577  105.530 134.578 1.00 74.28  ? 348 LEU A C     1 
ATOM   1689 O O     . LEU A 1 374 ? 72.502  105.915 134.114 1.00 111.74 ? 348 LEU A O     1 
ATOM   1690 C CB    . LEU A 1 374 ? 74.423  103.939 132.792 1.00 59.12  ? 348 LEU A CB    1 
ATOM   1691 C CG    . LEU A 1 374 ? 75.498  103.528 131.786 1.00 56.14  ? 348 LEU A CG    1 
ATOM   1692 C CD1   . LEU A 1 374 ? 75.217  102.227 131.053 1.00 59.32  ? 348 LEU A CD1   1 
ATOM   1693 C CD2   . LEU A 1 374 ? 75.664  104.597 130.815 1.00 56.74  ? 348 LEU A CD2   1 
ATOM   1694 N N     . VAL A 1 375 ? 73.797  105.509 135.893 1.00 60.57  ? 349 VAL A N     1 
ATOM   1695 C CA    . VAL A 1 375 ? 72.684  105.791 136.791 1.00 62.07  ? 349 VAL A CA    1 
ATOM   1696 C C     . VAL A 1 375 ? 72.657  107.260 137.198 1.00 79.75  ? 349 VAL A C     1 
ATOM   1697 O O     . VAL A 1 375 ? 73.056  107.598 138.306 1.00 83.69  ? 349 VAL A O     1 
ATOM   1698 C CB    . VAL A 1 375 ? 72.856  104.840 137.973 1.00 52.53  ? 349 VAL A CB    1 
ATOM   1699 C CG1   . VAL A 1 375 ? 71.961  105.118 139.137 1.00 52.72  ? 349 VAL A CG1   1 
ATOM   1700 C CG2   . VAL A 1 375 ? 72.481  103.469 137.526 1.00 65.79  ? 349 VAL A CG2   1 
ATOM   1701 N N     . LYS A 1 376 ? 72.212  108.138 136.292 1.00 83.23  ? 350 LYS A N     1 
ATOM   1702 C CA    . LYS A 1 376 ? 72.499  109.568 136.397 1.00 83.78  ? 350 LYS A CA    1 
ATOM   1703 C C     . LYS A 1 376 ? 71.644  110.163 137.506 1.00 98.03  ? 350 LYS A C     1 
ATOM   1704 O O     . LYS A 1 376 ? 70.580  110.740 137.270 1.00 116.35 ? 350 LYS A O     1 
ATOM   1705 C CB    . LYS A 1 376 ? 72.206  110.189 135.023 1.00 132.71 ? 350 LYS A CB    1 
ATOM   1706 C CG    . LYS A 1 376 ? 71.725  111.639 134.893 1.00 152.51 ? 350 LYS A CG    1 
ATOM   1707 C CD    . LYS A 1 376 ? 71.233  112.012 133.494 1.00 156.89 ? 350 LYS A CD    1 
ATOM   1708 C CE    . LYS A 1 376 ? 71.500  113.456 133.155 1.00 195.18 ? 350 LYS A CE    1 
ATOM   1709 N NZ    . LYS A 1 376 ? 70.782  114.468 133.944 1.00 194.18 ? 350 LYS A NZ    1 
ATOM   1710 N N     . LEU A 1 377 ? 72.092  109.961 138.737 1.00 104.39 ? 351 LEU A N     1 
ATOM   1711 C CA    . LEU A 1 377 ? 71.516  110.660 139.868 1.00 115.97 ? 351 LEU A CA    1 
ATOM   1712 C C     . LEU A 1 377 ? 72.254  111.988 140.023 1.00 178.34 ? 351 LEU A C     1 
ATOM   1713 O O     . LEU A 1 377 ? 73.261  112.212 139.353 1.00 204.44 ? 351 LEU A O     1 
ATOM   1714 C CB    . LEU A 1 377 ? 71.687  109.723 141.054 1.00 90.40  ? 351 LEU A CB    1 
ATOM   1715 C CG    . LEU A 1 377 ? 71.085  108.342 140.834 1.00 90.22  ? 351 LEU A CG    1 
ATOM   1716 C CD1   . LEU A 1 377 ? 70.975  107.465 142.084 1.00 92.21  ? 351 LEU A CD1   1 
ATOM   1717 C CD2   . LEU A 1 377 ? 69.723  108.575 140.204 1.00 109.18 ? 351 LEU A CD2   1 
ATOM   1718 N N     . GLN A 1 378 ? 71.753  112.879 140.884 1.00 190.12 ? 352 GLN A N     1 
ATOM   1719 C CA    . GLN A 1 378 ? 72.418  114.158 141.075 1.00 193.69 ? 352 GLN A CA    1 
ATOM   1720 C C     . GLN A 1 378 ? 73.106  114.212 142.448 1.00 163.06 ? 352 GLN A C     1 
ATOM   1721 O O     . GLN A 1 378 ? 73.798  115.182 142.753 1.00 159.86 ? 352 GLN A O     1 
ATOM   1722 C CB    . GLN A 1 378 ? 71.396  115.256 140.772 1.00 218.33 ? 352 GLN A CB    1 
ATOM   1723 C CG    . GLN A 1 378 ? 71.981  116.466 140.046 1.00 224.30 ? 352 GLN A CG    1 
ATOM   1724 C CD    . GLN A 1 378 ? 70.977  117.581 139.825 1.00 229.13 ? 352 GLN A CD    1 
ATOM   1725 O OE1   . GLN A 1 378 ? 69.847  117.339 139.385 1.00 266.15 ? 352 GLN A OE1   1 
ATOM   1726 N NE2   . GLN A 1 378 ? 71.368  118.813 140.131 1.00 191.01 ? 352 GLN A NE2   1 
ATOM   1727 N N     . GLU A 1 379 ? 72.966  113.150 143.255 1.00 125.41 ? 353 GLU A N     1 
ATOM   1728 C CA    . GLU A 1 379 ? 73.620  113.052 144.556 1.00 133.81 ? 353 GLU A CA    1 
ATOM   1729 C C     . GLU A 1 379 ? 74.843  112.136 144.463 1.00 124.83 ? 353 GLU A C     1 
ATOM   1730 O O     . GLU A 1 379 ? 75.284  111.525 145.448 1.00 94.33  ? 353 GLU A O     1 
ATOM   1731 C CB    . GLU A 1 379 ? 72.672  112.570 145.660 1.00 152.48 ? 353 GLU A CB    1 
ATOM   1732 C CG    . GLU A 1 379 ? 71.978  111.246 145.356 1.00 153.71 ? 353 GLU A CG    1 
ATOM   1733 C CD    . GLU A 1 379 ? 70.777  111.394 144.436 1.00 184.26 ? 353 GLU A CD    1 
ATOM   1734 O OE1   . GLU A 1 379 ? 70.840  112.143 143.421 1.00 137.88 ? 353 GLU A OE1   1 
ATOM   1735 O OE2   . GLU A 1 379 ? 69.763  110.728 144.751 1.00 222.77 ? 353 GLU A OE2   1 
ATOM   1736 N N     . LEU A 1 380 ? 75.339  112.022 143.234 1.00 122.67 ? 354 LEU A N     1 
ATOM   1737 C CA    . LEU A 1 380 ? 76.551  111.306 142.899 1.00 110.63 ? 354 LEU A CA    1 
ATOM   1738 C C     . LEU A 1 380 ? 77.409  112.274 142.098 1.00 132.69 ? 354 LEU A C     1 
ATOM   1739 O O     . LEU A 1 380 ? 78.088  111.851 141.167 1.00 144.89 ? 354 LEU A O     1 
ATOM   1740 C CB    . LEU A 1 380 ? 76.160  110.124 142.011 1.00 104.62 ? 354 LEU A CB    1 
ATOM   1741 C CG    . LEU A 1 380 ? 75.735  108.816 142.680 1.00 103.83 ? 354 LEU A CG    1 
ATOM   1742 C CD1   . LEU A 1 380 ? 74.863  108.939 143.889 1.00 110.64 ? 354 LEU A CD1   1 
ATOM   1743 C CD2   . LEU A 1 380 ? 75.014  107.990 141.650 1.00 99.83  ? 354 LEU A CD2   1 
ATOM   1744 N N     . ASN A 1 381 ? 77.309  113.582 142.388 1.00 133.99 ? 355 ASN A N     1 
ATOM   1745 C CA    . ASN A 1 381 ? 78.063  114.568 141.627 1.00 115.10 ? 355 ASN A CA    1 
ATOM   1746 C C     . ASN A 1 381 ? 79.189  115.119 142.498 1.00 106.08 ? 355 ASN A C     1 
ATOM   1747 O O     . ASN A 1 381 ? 78.909  115.734 143.522 1.00 139.74 ? 355 ASN A O     1 
ATOM   1748 C CB    . ASN A 1 381 ? 77.171  115.674 141.090 1.00 120.32 ? 355 ASN A CB    1 
ATOM   1749 C CG    . ASN A 1 381 ? 77.815  116.371 139.915 1.00 146.92 ? 355 ASN A CG    1 
ATOM   1750 O OD1   . ASN A 1 381 ? 78.747  115.828 139.312 1.00 121.99 ? 355 ASN A OD1   1 
ATOM   1751 N ND2   . ASN A 1 381 ? 77.320  117.547 139.546 1.00 169.13 ? 355 ASN A ND2   1 
ATOM   1752 N N     . TYR A 1 382 ? 80.440  114.827 142.103 1.00 99.76  ? 356 TYR A N     1 
ATOM   1753 C CA    . TYR A 1 382 ? 81.640  115.071 142.895 1.00 126.39 ? 356 TYR A CA    1 
ATOM   1754 C C     . TYR A 1 382 ? 81.707  114.173 144.129 1.00 135.96 ? 356 TYR A C     1 
ATOM   1755 O O     . TYR A 1 382 ? 82.102  114.590 145.219 1.00 161.36 ? 356 TYR A O     1 
ATOM   1756 C CB    . TYR A 1 382 ? 81.698  116.522 143.360 1.00 152.47 ? 356 TYR A CB    1 
ATOM   1757 C CG    . TYR A 1 382 ? 81.573  117.512 142.220 1.00 133.74 ? 356 TYR A CG    1 
ATOM   1758 C CD1   . TYR A 1 382 ? 82.645  117.715 141.357 1.00 136.51 ? 356 TYR A CD1   1 
ATOM   1759 C CD2   . TYR A 1 382 ? 80.418  118.258 142.044 1.00 105.20 ? 356 TYR A CD2   1 
ATOM   1760 C CE1   . TYR A 1 382 ? 82.568  118.636 140.331 1.00 155.12 ? 356 TYR A CE1   1 
ATOM   1761 C CE2   . TYR A 1 382 ? 80.330  119.183 141.020 1.00 144.64 ? 356 TYR A CE2   1 
ATOM   1762 C CZ    . TYR A 1 382 ? 81.404  119.369 140.160 1.00 177.58 ? 356 TYR A CZ    1 
ATOM   1763 O OH    . TYR A 1 382 ? 81.326  120.279 139.143 1.00 204.25 ? 356 TYR A OH    1 
ATOM   1764 N N     . ASN A 1 383 ? 81.327  112.924 143.933 1.00 112.15 ? 357 ASN A N     1 
ATOM   1765 C CA    . ASN A 1 383 ? 81.177  111.996 145.024 1.00 105.85 ? 357 ASN A CA    1 
ATOM   1766 C C     . ASN A 1 383 ? 82.101  110.820 144.751 1.00 104.82 ? 357 ASN A C     1 
ATOM   1767 O O     . ASN A 1 383 ? 82.810  110.394 145.655 1.00 109.79 ? 357 ASN A O     1 
ATOM   1768 C CB    . ASN A 1 383 ? 79.696  111.686 145.197 1.00 107.68 ? 357 ASN A CB    1 
ATOM   1769 C CG    . ASN A 1 383 ? 79.045  112.715 146.088 1.00 139.55 ? 357 ASN A CG    1 
ATOM   1770 O OD1   . ASN A 1 383 ? 78.930  113.892 145.720 1.00 121.22 ? 357 ASN A OD1   1 
ATOM   1771 N ND2   . ASN A 1 383 ? 78.633  112.294 147.277 1.00 176.76 ? 357 ASN A ND2   1 
ATOM   1772 N N     . LEU A 1 384 ? 82.101  110.344 143.491 1.00 102.82 ? 358 LEU A N     1 
ATOM   1773 C CA    . LEU A 1 384 ? 82.863  109.175 143.071 1.00 100.65 ? 358 LEU A CA    1 
ATOM   1774 C C     . LEU A 1 384 ? 84.244  109.556 142.509 1.00 99.93  ? 358 LEU A C     1 
ATOM   1775 O O     . LEU A 1 384 ? 84.388  110.234 141.476 1.00 73.73  ? 358 LEU A O     1 
ATOM   1776 C CB    . LEU A 1 384 ? 82.072  108.395 142.027 1.00 100.12 ? 358 LEU A CB    1 
ATOM   1777 C CG    . LEU A 1 384 ? 80.630  108.064 142.388 1.00 112.71 ? 358 LEU A CG    1 
ATOM   1778 C CD1   . LEU A 1 384 ? 79.982  107.642 141.072 1.00 135.57 ? 358 LEU A CD1   1 
ATOM   1779 C CD2   . LEU A 1 384 ? 80.485  107.013 143.481 1.00 94.84  ? 358 LEU A CD2   1 
ATOM   1780 N N     . LYS A 1 385 ? 85.274  109.024 143.167 1.00 73.41  ? 359 LYS A N     1 
ATOM   1781 C CA    . LYS A 1 385 ? 86.626  109.300 142.762 1.00 93.48  ? 359 LYS A CA    1 
ATOM   1782 C C     . LYS A 1 385 ? 87.209  108.032 142.139 1.00 90.82  ? 359 LYS A C     1 
ATOM   1783 O O     . LYS A 1 385 ? 87.555  107.066 142.823 1.00 113.24 ? 359 LYS A O     1 
ATOM   1784 C CB    . LYS A 1 385 ? 87.352  109.764 144.029 1.00 141.79 ? 359 LYS A CB    1 
ATOM   1785 C CG    . LYS A 1 385 ? 88.871  109.728 143.913 1.00 205.94 ? 359 LYS A CG    1 
ATOM   1786 C CD    . LYS A 1 385 ? 89.643  109.599 145.223 1.00 246.13 ? 359 LYS A CD    1 
ATOM   1787 C CE    . LYS A 1 385 ? 89.651  110.848 146.051 1.00 253.90 ? 359 LYS A CE    1 
ATOM   1788 N NZ    . LYS A 1 385 ? 90.383  110.671 147.309 1.00 225.98 ? 359 LYS A NZ    1 
ATOM   1789 N N     . VAL A 1 386 ? 87.354  108.065 140.828 1.00 71.07  ? 360 VAL A N     1 
ATOM   1790 C CA    . VAL A 1 386 ? 87.852  106.928 140.086 1.00 85.65  ? 360 VAL A CA    1 
ATOM   1791 C C     . VAL A 1 386 ? 89.374  106.909 140.218 1.00 81.82  ? 360 VAL A C     1 
ATOM   1792 O O     . VAL A 1 386 ? 89.993  107.910 139.852 1.00 64.19  ? 360 VAL A O     1 
ATOM   1793 C CB    . VAL A 1 386 ? 87.401  107.142 138.618 1.00 87.40  ? 360 VAL A CB    1 
ATOM   1794 C CG1   . VAL A 1 386 ? 88.044  106.169 137.629 1.00 96.63  ? 360 VAL A CG1   1 
ATOM   1795 C CG2   . VAL A 1 386 ? 85.886  107.132 138.476 1.00 77.95  ? 360 VAL A CG2   1 
ATOM   1796 N N     . LYS A 1 387 ? 89.963  105.762 140.615 1.00 75.04  ? 361 LYS A N     1 
ATOM   1797 C CA    . LYS A 1 387 ? 91.392  105.552 140.409 1.00 86.57  ? 361 LYS A CA    1 
ATOM   1798 C C     . LYS A 1 387 ? 91.737  104.449 139.411 1.00 84.83  ? 361 LYS A C     1 
ATOM   1799 O O     . LYS A 1 387 ? 91.189  103.358 139.475 1.00 116.04 ? 361 LYS A O     1 
ATOM   1800 C CB    . LYS A 1 387 ? 92.063  105.208 141.729 1.00 97.42  ? 361 LYS A CB    1 
ATOM   1801 C CG    . LYS A 1 387 ? 91.952  103.790 142.162 1.00 125.71 ? 361 LYS A CG    1 
ATOM   1802 C CD    . LYS A 1 387 ? 92.324  103.627 143.633 1.00 177.54 ? 361 LYS A CD    1 
ATOM   1803 C CE    . LYS A 1 387 ? 93.737  104.033 143.999 1.00 199.83 ? 361 LYS A CE    1 
ATOM   1804 N NZ    . LYS A 1 387 ? 94.775  103.031 143.713 1.00 184.69 ? 361 LYS A NZ    1 
ATOM   1805 N N     . VAL A 1 388 ? 92.729  104.726 138.557 1.00 75.14  ? 362 VAL A N     1 
ATOM   1806 C CA    . VAL A 1 388 ? 93.186  103.850 137.484 1.00 60.68  ? 362 VAL A CA    1 
ATOM   1807 C C     . VAL A 1 388 ? 94.261  102.918 137.992 1.00 55.10  ? 362 VAL A C     1 
ATOM   1808 O O     . VAL A 1 388 ? 95.068  103.370 138.778 1.00 86.90  ? 362 VAL A O     1 
ATOM   1809 C CB    . VAL A 1 388 ? 93.895  104.659 136.398 1.00 61.94  ? 362 VAL A CB    1 
ATOM   1810 C CG1   . VAL A 1 388 ? 94.435  103.684 135.367 1.00 62.71  ? 362 VAL A CG1   1 
ATOM   1811 C CG2   . VAL A 1 388 ? 93.031  105.778 135.815 1.00 65.46  ? 362 VAL A CG2   1 
ATOM   1812 N N     . LEU A 1 389 ? 94.349  101.689 137.499 1.00 55.49  ? 363 LEU A N     1 
ATOM   1813 C CA    . LEU A 1 389 ? 95.380  100.766 137.949 1.00 65.34  ? 363 LEU A CA    1 
ATOM   1814 C C     . LEU A 1 389 ? 95.949  100.084 136.727 1.00 70.17  ? 363 LEU A C     1 
ATOM   1815 O O     . LEU A 1 389 ? 95.465  100.373 135.651 1.00 77.22  ? 363 LEU A O     1 
ATOM   1816 C CB    . LEU A 1 389 ? 94.849  99.740  138.932 1.00 59.66  ? 363 LEU A CB    1 
ATOM   1817 C CG    . LEU A 1 389 ? 93.870  100.303 139.949 1.00 85.27  ? 363 LEU A CG    1 
ATOM   1818 C CD1   . LEU A 1 389 ? 93.456  99.226  140.924 1.00 127.99 ? 363 LEU A CD1   1 
ATOM   1819 C CD2   . LEU A 1 389 ? 94.499  101.435 140.698 1.00 120.16 ? 363 LEU A CD2   1 
ATOM   1820 N N     . PHE A 1 390 ? 96.982  99.239  136.875 1.00 77.32  ? 364 PHE A N     1 
ATOM   1821 C CA    . PHE A 1 390 ? 97.503  98.548  135.700 1.00 70.26  ? 364 PHE A CA    1 
ATOM   1822 C C     . PHE A 1 390 ? 98.080  97.178  136.041 1.00 69.22  ? 364 PHE A C     1 
ATOM   1823 O O     . PHE A 1 390 ? 98.806  96.985  137.000 1.00 107.80 ? 364 PHE A O     1 
ATOM   1824 C CB    . PHE A 1 390 ? 98.500  99.406  134.937 1.00 61.24  ? 364 PHE A CB    1 
ATOM   1825 C CG    . PHE A 1 390 ? 98.996  98.865  133.618 1.00 76.07  ? 364 PHE A CG    1 
ATOM   1826 C CD1   . PHE A 1 390 ? 99.931  97.839  133.558 1.00 79.21  ? 364 PHE A CD1   1 
ATOM   1827 C CD2   . PHE A 1 390 ? 98.565  99.437  132.432 1.00 96.92  ? 364 PHE A CD2   1 
ATOM   1828 C CE1   . PHE A 1 390 ? 100.410 97.382  132.324 1.00 89.06  ? 364 PHE A CE1   1 
ATOM   1829 C CE2   . PHE A 1 390 ? 99.040  98.962  131.213 1.00 111.08 ? 364 PHE A CE2   1 
ATOM   1830 C CZ    . PHE A 1 390 ? 99.986  97.952  131.160 1.00 82.03  ? 364 PHE A CZ    1 
ATOM   1831 N N     . ASP A 1 391 ? 97.667  96.223  135.229 1.00 77.46  ? 365 ASP A N     1 
ATOM   1832 C CA    . ASP A 1 391 ? 97.972  94.820  135.365 1.00 70.73  ? 365 ASP A CA    1 
ATOM   1833 C C     . ASP A 1 391 ? 97.466  94.247  136.682 1.00 79.34  ? 365 ASP A C     1 
ATOM   1834 O O     . ASP A 1 391 ? 97.805  93.097  136.955 1.00 86.21  ? 365 ASP A O     1 
ATOM   1835 C CB    . ASP A 1 391 ? 99.417  94.594  135.002 1.00 98.91  ? 365 ASP A CB    1 
ATOM   1836 C CG    . ASP A 1 391 ? 99.681  94.269  133.538 1.00 112.36 ? 365 ASP A CG    1 
ATOM   1837 O OD1   . ASP A 1 391 ? 98.692  94.213  132.778 1.00 107.57 ? 365 ASP A OD1   1 
ATOM   1838 O OD2   . ASP A 1 391 ? 100.883 94.057  133.189 1.00 105.66 ? 365 ASP A OD2   1 
ATOM   1839 N N     . LYS A 1 392 ? 96.550  94.948  137.391 1.00 88.91  ? 366 LYS A N     1 
ATOM   1840 C CA    . LYS A 1 392 ? 96.056  94.498  138.695 1.00 107.46 ? 366 LYS A CA    1 
ATOM   1841 C C     . LYS A 1 392 ? 95.335  93.141  138.650 1.00 106.26 ? 366 LYS A C     1 
ATOM   1842 O O     . LYS A 1 392 ? 94.204  93.053  138.165 1.00 127.04 ? 366 LYS A O     1 
ATOM   1843 C CB    . LYS A 1 392 ? 95.018  95.434  139.316 1.00 111.05 ? 366 LYS A CB    1 
ATOM   1844 C CG    . LYS A 1 392 ? 94.499  94.988  140.670 1.00 121.10 ? 366 LYS A CG    1 
ATOM   1845 C CD    . LYS A 1 392 ? 93.356  95.806  141.273 1.00 157.57 ? 366 LYS A CD    1 
ATOM   1846 C CE    . LYS A 1 392 ? 91.948  95.389  140.906 1.00 153.02 ? 366 LYS A CE    1 
ATOM   1847 N NZ    . LYS A 1 392 ? 91.049  95.753  142.007 1.00 154.53 ? 366 LYS A NZ    1 
ATOM   1848 N N     . ASP A 1 393 ? 95.977  92.127  139.254 1.00 94.74  ? 367 ASP A N     1 
ATOM   1849 C CA    . ASP A 1 393 ? 95.423  90.808  139.531 1.00 107.61 ? 367 ASP A CA    1 
ATOM   1850 C C     . ASP A 1 393 ? 95.679  89.917  138.332 1.00 110.03 ? 367 ASP A C     1 
ATOM   1851 O O     . ASP A 1 393 ? 94.997  88.908  138.155 1.00 123.36 ? 367 ASP A O     1 
ATOM   1852 C CB    . ASP A 1 393 ? 93.960  90.821  139.964 1.00 157.93 ? 367 ASP A CB    1 
ATOM   1853 C CG    . ASP A 1 393 ? 93.689  91.216  141.414 1.00 230.16 ? 367 ASP A CG    1 
ATOM   1854 O OD1   . ASP A 1 393 ? 94.664  91.412  142.183 1.00 229.62 ? 367 ASP A OD1   1 
ATOM   1855 O OD2   . ASP A 1 393 ? 92.494  91.322  141.768 1.00 267.74 ? 367 ASP A OD2   1 
ATOM   1856 N N     . VAL A 1 394 ? 96.683  90.293  137.535 1.00 105.76 ? 368 VAL A N     1 
ATOM   1857 C CA    . VAL A 1 394 ? 97.006  89.564  136.321 1.00 131.16 ? 368 VAL A CA    1 
ATOM   1858 C C     . VAL A 1 394 ? 97.945  88.405  136.639 1.00 136.06 ? 368 VAL A C     1 
ATOM   1859 O O     . VAL A 1 394 ? 99.135  88.620  136.846 1.00 155.83 ? 368 VAL A O     1 
ATOM   1860 C CB    . VAL A 1 394 ? 97.653  90.527  135.315 1.00 138.29 ? 368 VAL A CB    1 
ATOM   1861 C CG1   . VAL A 1 394 ? 98.320  89.773  134.174 1.00 149.17 ? 368 VAL A CG1   1 
ATOM   1862 C CG2   . VAL A 1 394 ? 96.641  91.527  134.785 1.00 142.19 ? 368 VAL A CG2   1 
ATOM   1863 N N     . ASN A 1 395 ? 97.425  87.175  136.635 1.00 134.85 ? 369 ASN A N     1 
ATOM   1864 C CA    . ASN A 1 395 ? 98.204  86.052  137.128 1.00 154.10 ? 369 ASN A CA    1 
ATOM   1865 C C     . ASN A 1 395 ? 99.309  85.717  136.130 1.00 160.43 ? 369 ASN A C     1 
ATOM   1866 O O     . ASN A 1 395 ? 100.190 84.919  136.447 1.00 166.88 ? 369 ASN A O     1 
ATOM   1867 C CB    . ASN A 1 395 ? 97.330  84.854  137.483 1.00 172.99 ? 369 ASN A CB    1 
ATOM   1868 C CG    . ASN A 1 395 ? 96.355  85.186  138.590 1.00 199.03 ? 369 ASN A CG    1 
ATOM   1869 O OD1   . ASN A 1 395 ? 96.654  84.967  139.771 1.00 194.30 ? 369 ASN A OD1   1 
ATOM   1870 N ND2   . ASN A 1 395 ? 95.206  85.750  138.240 1.00 201.58 ? 369 ASN A ND2   1 
ATOM   1871 N N     . GLU A 1 396 ? 99.265  86.352  134.943 1.00 157.12 ? 370 GLU A N     1 
ATOM   1872 C CA    . GLU A 1 396 ? 100.209 86.070  133.866 1.00 140.18 ? 370 GLU A CA    1 
ATOM   1873 C C     . GLU A 1 396 ? 101.530 86.762  134.147 1.00 124.69 ? 370 GLU A C     1 
ATOM   1874 O O     . GLU A 1 396 ? 102.407 86.715  133.282 1.00 120.35 ? 370 GLU A O     1 
ATOM   1875 C CB    . GLU A 1 396 ? 99.818  86.521  132.454 1.00 124.64 ? 370 GLU A CB    1 
ATOM   1876 C CG    . GLU A 1 396 ? 98.866  85.579  131.714 1.00 146.55 ? 370 GLU A CG    1 
ATOM   1877 C CD    . GLU A 1 396 ? 97.429  85.468  132.222 1.00 181.90 ? 370 GLU A CD    1 
ATOM   1878 O OE1   . GLU A 1 396 ? 97.152  85.794  133.399 1.00 216.12 ? 370 GLU A OE1   1 
ATOM   1879 O OE2   . GLU A 1 396 ? 96.555  85.082  131.413 1.00 148.20 ? 370 GLU A OE2   1 
ATOM   1880 N N     . ARG A 1 397 ? 101.635 87.401  135.327 1.00 104.11 ? 371 ARG A N     1 
ATOM   1881 C CA    . ARG A 1 397 ? 102.880 88.002  135.773 1.00 98.73  ? 371 ARG A CA    1 
ATOM   1882 C C     . ARG A 1 397 ? 103.746 86.958  136.463 1.00 129.83 ? 371 ARG A C     1 
ATOM   1883 O O     . ARG A 1 397 ? 104.971 87.069  136.446 1.00 171.33 ? 371 ARG A O     1 
ATOM   1884 C CB    . ARG A 1 397 ? 102.665 89.194  136.706 1.00 99.24  ? 371 ARG A CB    1 
ATOM   1885 C CG    . ARG A 1 397 ? 102.130 90.414  135.968 1.00 101.83 ? 371 ARG A CG    1 
ATOM   1886 C CD    . ARG A 1 397 ? 101.620 91.485  136.957 1.00 111.44 ? 371 ARG A CD    1 
ATOM   1887 N NE    . ARG A 1 397 ? 100.432 91.074  137.720 1.00 110.47 ? 371 ARG A NE    1 
ATOM   1888 C CZ    . ARG A 1 397 ? 99.968  91.658  138.826 1.00 141.29 ? 371 ARG A CZ    1 
ATOM   1889 N NH1   . ARG A 1 397 ? 100.401 92.863  139.192 1.00 139.70 ? 371 ARG A NH1   1 
ATOM   1890 N NH2   . ARG A 1 397 ? 99.059  91.023  139.556 1.00 143.19 ? 371 ARG A NH2   1 
ATOM   1891 N N     . ASN A 1 398 ? 103.108 85.958  137.079 1.00 174.28 ? 372 ASN A N     1 
ATOM   1892 C CA    . ASN A 1 398 ? 103.838 84.931  137.807 1.00 190.69 ? 372 ASN A CA    1 
ATOM   1893 C C     . ASN A 1 398 ? 104.022 83.724  136.884 1.00 162.57 ? 372 ASN A C     1 
ATOM   1894 O O     . ASN A 1 398 ? 105.092 83.119  136.873 1.00 148.64 ? 372 ASN A O     1 
ATOM   1895 C CB    . ASN A 1 398 ? 103.196 84.664  139.169 1.00 192.15 ? 372 ASN A CB    1 
ATOM   1896 C CG    . ASN A 1 398 ? 102.673 85.926  139.831 1.00 209.30 ? 372 ASN A CG    1 
ATOM   1897 O OD1   . ASN A 1 398 ? 101.530 85.947  140.300 1.00 232.36 ? 372 ASN A OD1   1 
ATOM   1898 N ND2   . ASN A 1 398 ? 103.469 86.988  139.890 1.00 186.44 ? 372 ASN A ND2   1 
ATOM   1899 N N     . THR A 1 399 ? 103.011 83.427  136.058 1.00 160.87 ? 373 THR A N     1 
ATOM   1900 C CA    . THR A 1 399 ? 102.962 82.168  135.328 1.00 194.54 ? 373 THR A CA    1 
ATOM   1901 C C     . THR A 1 399 ? 103.692 82.264  133.990 1.00 178.45 ? 373 THR A C     1 
ATOM   1902 O O     . THR A 1 399 ? 104.323 81.294  133.562 1.00 192.58 ? 373 THR A O     1 
ATOM   1903 C CB    . THR A 1 399 ? 101.514 81.712  135.133 1.00 226.94 ? 373 THR A CB    1 
ATOM   1904 O OG1   . THR A 1 399 ? 100.780 82.728  134.457 1.00 210.65 ? 373 THR A OG1   1 
ATOM   1905 C CG2   . THR A 1 399 ? 100.834 81.407  136.455 1.00 264.50 ? 373 THR A CG2   1 
ATOM   1906 N N     . VAL A 1 400 ? 103.561 83.401  133.300 1.00 159.80 ? 374 VAL A N     1 
ATOM   1907 C CA    . VAL A 1 400 ? 104.149 83.530  131.977 1.00 158.96 ? 374 VAL A CA    1 
ATOM   1908 C C     . VAL A 1 400 ? 105.557 84.082  132.140 1.00 167.07 ? 374 VAL A C     1 
ATOM   1909 O O     . VAL A 1 400 ? 105.748 85.139  132.739 1.00 174.37 ? 374 VAL A O     1 
ATOM   1910 C CB    . VAL A 1 400 ? 103.333 84.390  130.998 1.00 148.38 ? 374 VAL A CB    1 
ATOM   1911 C CG1   . VAL A 1 400 ? 104.188 84.879  129.847 1.00 168.27 ? 374 VAL A CG1   1 
ATOM   1912 C CG2   . VAL A 1 400 ? 102.131 83.630  130.452 1.00 164.01 ? 374 VAL A CG2   1 
ATOM   1913 N N     . LYS A 1 401 ? 106.531 83.349  131.594 1.00 140.72 ? 375 LYS A N     1 
ATOM   1914 C CA    . LYS A 1 401 ? 107.919 83.748  131.711 1.00 129.32 ? 375 LYS A CA    1 
ATOM   1915 C C     . LYS A 1 401 ? 108.170 84.944  130.805 1.00 139.85 ? 375 LYS A C     1 
ATOM   1916 O O     . LYS A 1 401 ? 107.900 84.871  129.611 1.00 211.61 ? 375 LYS A O     1 
ATOM   1917 C CB    . LYS A 1 401 ? 108.804 82.577  131.291 1.00 151.10 ? 375 LYS A CB    1 
ATOM   1918 C CG    . LYS A 1 401 ? 110.250 82.969  130.995 1.00 191.91 ? 375 LYS A CG    1 
ATOM   1919 C CD    . LYS A 1 401 ? 111.160 81.801  130.625 1.00 216.11 ? 375 LYS A CD    1 
ATOM   1920 C CE    . LYS A 1 401 ? 111.387 80.808  131.721 1.00 212.98 ? 375 LYS A CE    1 
ATOM   1921 N NZ    . LYS A 1 401 ? 112.115 79.637  131.229 1.00 195.84 ? 375 LYS A NZ    1 
ATOM   1922 N N     . GLY A 1 402 ? 108.698 86.033  131.354 1.00 136.00 ? 376 GLY A N     1 
ATOM   1923 C CA    . GLY A 1 402 ? 109.106 87.151  130.517 1.00 160.65 ? 376 GLY A CA    1 
ATOM   1924 C C     . GLY A 1 402 ? 108.066 88.269  130.504 1.00 136.14 ? 376 GLY A C     1 
ATOM   1925 O O     . GLY A 1 402 ? 108.188 89.256  129.770 1.00 127.67 ? 376 GLY A O     1 
ATOM   1926 N N     . PHE A 1 403 ? 107.052 88.131  131.344 1.00 83.70  ? 377 PHE A N     1 
ATOM   1927 C CA    . PHE A 1 403 ? 106.015 89.123  131.286 1.00 82.08  ? 377 PHE A CA    1 
ATOM   1928 C C     . PHE A 1 403 ? 106.566 90.447  131.769 1.00 62.12  ? 377 PHE A C     1 
ATOM   1929 O O     . PHE A 1 403 ? 106.839 90.557  132.951 1.00 87.10  ? 377 PHE A O     1 
ATOM   1930 C CB    . PHE A 1 403 ? 104.814 88.769  132.157 1.00 102.38 ? 377 PHE A CB    1 
ATOM   1931 C CG    . PHE A 1 403 ? 103.492 89.400  131.746 1.00 72.00  ? 377 PHE A CG    1 
ATOM   1932 C CD1   . PHE A 1 403 ? 102.761 88.831  130.716 1.00 72.98  ? 377 PHE A CD1   1 
ATOM   1933 C CD2   . PHE A 1 403 ? 102.959 90.471  132.447 1.00 66.81  ? 377 PHE A CD2   1 
ATOM   1934 C CE1   . PHE A 1 403 ? 101.552 89.385  130.332 1.00 100.74 ? 377 PHE A CE1   1 
ATOM   1935 C CE2   . PHE A 1 403 ? 101.733 91.005  132.086 1.00 88.86  ? 377 PHE A CE2   1 
ATOM   1936 C CZ    . PHE A 1 403 ? 101.037 90.472  131.016 1.00 98.40  ? 377 PHE A CZ    1 
ATOM   1937 N N     . ARG A 1 404 ? 106.570 91.447  130.879 1.00 59.77  ? 378 ARG A N     1 
ATOM   1938 C CA    . ARG A 1 404 ? 106.856 92.853  131.176 1.00 66.54  ? 378 ARG A CA    1 
ATOM   1939 C C     . ARG A 1 404 ? 106.038 93.353  132.343 1.00 56.61  ? 378 ARG A C     1 
ATOM   1940 O O     . ARG A 1 404 ? 105.159 92.611  132.747 1.00 70.15  ? 378 ARG A O     1 
ATOM   1941 C CB    . ARG A 1 404 ? 106.566 93.770  129.991 1.00 69.18  ? 378 ARG A CB    1 
ATOM   1942 C CG    . ARG A 1 404 ? 107.375 93.128  128.882 1.00 79.52  ? 378 ARG A CG    1 
ATOM   1943 C CD    . ARG A 1 404 ? 107.584 94.023  127.729 1.00 92.77  ? 378 ARG A CD    1 
ATOM   1944 N NE    . ARG A 1 404 ? 106.636 93.670  126.673 1.00 81.74  ? 378 ARG A NE    1 
ATOM   1945 C CZ    . ARG A 1 404 ? 105.820 94.528  126.128 1.00 84.17  ? 378 ARG A CZ    1 
ATOM   1946 N NH1   . ARG A 1 404 ? 105.690 95.694  126.692 1.00 81.12  ? 378 ARG A NH1   1 
ATOM   1947 N NH2   . ARG A 1 404 ? 105.079 94.208  125.083 1.00 114.26 ? 378 ARG A NH2   1 
ATOM   1948 N N     . LYS A 1 405 ? 106.401 94.526  132.899 1.00 62.76  ? 379 LYS A N     1 
ATOM   1949 C CA    . LYS A 1 405 ? 105.586 95.187  133.924 1.00 90.32  ? 379 LYS A CA    1 
ATOM   1950 C C     . LYS A 1 405 ? 105.661 96.701  133.737 1.00 84.75  ? 379 LYS A C     1 
ATOM   1951 O O     . LYS A 1 405 ? 106.601 97.168  133.093 1.00 114.36 ? 379 LYS A O     1 
ATOM   1952 C CB    . LYS A 1 405 ? 106.079 94.769  135.311 1.00 101.77 ? 379 LYS A CB    1 
ATOM   1953 C CG    . LYS A 1 405 ? 106.129 93.254  135.522 1.00 117.04 ? 379 LYS A CG    1 
ATOM   1954 C CD    . LYS A 1 405 ? 106.192 92.810  136.984 1.00 158.61 ? 379 LYS A CD    1 
ATOM   1955 C CE    . LYS A 1 405 ? 106.166 91.311  137.126 1.00 169.36 ? 379 LYS A CE    1 
ATOM   1956 N NZ    . LYS A 1 405 ? 107.125 90.628  136.245 1.00 162.40 ? 379 LYS A NZ    1 
ATOM   1957 N N     . PHE A 1 406 ? 104.718 97.485  134.282 1.00 56.08  ? 380 PHE A N     1 
ATOM   1958 C CA    . PHE A 1 406 ? 104.687 98.922  133.967 1.00 57.57  ? 380 PHE A CA    1 
ATOM   1959 C C     . PHE A 1 406 ? 103.999 99.668  135.125 1.00 69.03  ? 380 PHE A C     1 
ATOM   1960 O O     . PHE A 1 406 ? 103.464 99.066  136.059 1.00 75.29  ? 380 PHE A O     1 
ATOM   1961 C CB    . PHE A 1 406 ? 103.948 99.358  132.666 1.00 64.81  ? 380 PHE A CB    1 
ATOM   1962 C CG    . PHE A 1 406 ? 104.398 98.673  131.395 1.00 58.77  ? 380 PHE A CG    1 
ATOM   1963 C CD1   . PHE A 1 406 ? 104.042 97.355  131.113 1.00 57.10  ? 380 PHE A CD1   1 
ATOM   1964 C CD2   . PHE A 1 406 ? 105.324 99.285  130.581 1.00 69.81  ? 380 PHE A CD2   1 
ATOM   1965 C CE1   . PHE A 1 406 ? 104.638 96.677  130.055 1.00 69.18  ? 380 PHE A CE1   1 
ATOM   1966 C CE2   . PHE A 1 406 ? 105.914 98.597  129.507 1.00 70.72  ? 380 PHE A CE2   1 
ATOM   1967 C CZ    . PHE A 1 406 ? 105.575 97.300  129.240 1.00 59.46  ? 380 PHE A CZ    1 
ATOM   1968 N N     . ASN A 1 407 ? 103.972 101.001 135.022 1.00 75.75  ? 381 ASN A N     1 
ATOM   1969 C CA    . ASN A 1 407 ? 103.288 101.876 135.956 1.00 81.11  ? 381 ASN A CA    1 
ATOM   1970 C C     . ASN A 1 407 ? 102.730 103.094 135.220 1.00 77.72  ? 381 ASN A C     1 
ATOM   1971 O O     . ASN A 1 407 ? 103.365 103.722 134.362 1.00 74.16  ? 381 ASN A O     1 
ATOM   1972 C CB    . ASN A 1 407 ? 104.281 102.439 136.964 1.00 116.73 ? 381 ASN A CB    1 
ATOM   1973 C CG    . ASN A 1 407 ? 105.398 101.466 137.244 1.00 129.41 ? 381 ASN A CG    1 
ATOM   1974 O OD1   . ASN A 1 407 ? 106.517 101.641 136.745 1.00 116.62 ? 381 ASN A OD1   1 
ATOM   1975 N ND2   . ASN A 1 407 ? 105.092 100.418 137.999 1.00 148.33 ? 381 ASN A ND2   1 
ATOM   1976 N N     . ILE A 1 408 ? 101.562 103.516 135.648 1.00 72.15  ? 382 ILE A N     1 
ATOM   1977 C CA    . ILE A 1 408 ? 100.890 104.622 134.992 1.00 80.40  ? 382 ILE A CA    1 
ATOM   1978 C C     . ILE A 1 408 ? 101.492 105.885 135.612 1.00 74.16  ? 382 ILE A C     1 
ATOM   1979 O O     . ILE A 1 408 ? 101.668 105.942 136.839 1.00 75.84  ? 382 ILE A O     1 
ATOM   1980 C CB    . ILE A 1 408 ? 99.349  104.469 135.171 1.00 94.40  ? 382 ILE A CB    1 
ATOM   1981 C CG1   . ILE A 1 408 ? 98.886  103.010 135.145 1.00 118.44 ? 382 ILE A CG1   1 
ATOM   1982 C CG2   . ILE A 1 408 ? 98.522  105.253 134.165 1.00 87.51  ? 382 ILE A CG2   1 
ATOM   1983 C CD1   . ILE A 1 408 ? 98.693  102.392 136.526 1.00 148.12 ? 382 ILE A CD1   1 
ATOM   1984 N N     . LEU A 1 409 ? 101.815 106.891 134.785 1.00 80.26  ? 383 LEU A N     1 
ATOM   1985 C CA    . LEU A 1 409 ? 102.595 108.025 135.263 1.00 95.31  ? 383 LEU A CA    1 
ATOM   1986 C C     . LEU A 1 409 ? 101.698 109.195 135.603 1.00 120.54 ? 383 LEU A C     1 
ATOM   1987 O O     . LEU A 1 409 ? 101.799 109.696 136.726 1.00 162.94 ? 383 LEU A O     1 
ATOM   1988 C CB    . LEU A 1 409 ? 103.722 108.490 134.350 1.00 106.60 ? 383 LEU A CB    1 
ATOM   1989 C CG    . LEU A 1 409 ? 105.122 108.114 134.849 1.00 119.69 ? 383 LEU A CG    1 
ATOM   1990 C CD1   . LEU A 1 409 ? 105.316 106.596 134.886 1.00 118.20 ? 383 LEU A CD1   1 
ATOM   1991 C CD2   . LEU A 1 409 ? 106.173 108.786 133.991 1.00 146.31 ? 383 LEU A CD2   1 
ATOM   1992 N N     . GLY A 1 410 ? 100.866 109.627 134.640 1.00 121.96 ? 384 GLY A N     1 
ATOM   1993 C CA    . GLY A 1 410 ? 100.083 110.860 134.765 1.00 134.53 ? 384 GLY A CA    1 
ATOM   1994 C C     . GLY A 1 410 ? 99.337  110.995 136.101 1.00 137.08 ? 384 GLY A C     1 
ATOM   1995 O O     . GLY A 1 410 ? 99.674  110.372 137.122 1.00 117.84 ? 384 GLY A O     1 
ATOM   1996 N N     . THR A 1 411 ? 98.303  111.837 136.114 1.00 131.80 ? 385 THR A N     1 
ATOM   1997 C CA    . THR A 1 411 ? 97.428  111.837 137.277 1.00 156.28 ? 385 THR A CA    1 
ATOM   1998 C C     . THR A 1 411 ? 96.423  110.708 137.115 1.00 127.81 ? 385 THR A C     1 
ATOM   1999 O O     . THR A 1 411 ? 95.675  110.717 136.146 1.00 108.43 ? 385 THR A O     1 
ATOM   2000 C CB    . THR A 1 411 ? 96.691  113.156 137.480 1.00 159.17 ? 385 THR A CB    1 
ATOM   2001 O OG1   . THR A 1 411 ? 95.885  112.839 138.620 1.00 129.48 ? 385 THR A OG1   1 
ATOM   2002 C CG2   . THR A 1 411 ? 95.916  113.588 136.245 1.00 163.96 ? 385 THR A CG2   1 
ATOM   2003 N N     . HIS A 1 412 ? 96.430  109.765 138.062 1.00 110.25 ? 386 HIS A N     1 
ATOM   2004 C CA    . HIS A 1 412 ? 95.414  108.739 138.132 1.00 88.71  ? 386 HIS A CA    1 
ATOM   2005 C C     . HIS A 1 412 ? 94.187  109.426 138.717 1.00 98.64  ? 386 HIS A C     1 
ATOM   2006 O O     . HIS A 1 412 ? 93.451  110.097 138.003 1.00 124.10 ? 386 HIS A O     1 
ATOM   2007 C CB    . HIS A 1 412 ? 95.867  107.578 139.011 1.00 136.01 ? 386 HIS A CB    1 
ATOM   2008 C CG    . HIS A 1 412 ? 97.343  107.429 139.055 1.00 179.10 ? 386 HIS A CG    1 
ATOM   2009 N ND1   . HIS A 1 412 ? 98.029  107.225 140.233 1.00 192.01 ? 386 HIS A ND1   1 
ATOM   2010 C CD2   . HIS A 1 412 ? 98.258  107.482 138.079 1.00 168.82 ? 386 HIS A CD2   1 
ATOM   2011 C CE1   . HIS A 1 412 ? 99.320  107.124 139.957 1.00 218.47 ? 386 HIS A CE1   1 
ATOM   2012 N NE2   . HIS A 1 412 ? 99.481  107.279 138.657 1.00 201.94 ? 386 HIS A NE2   1 
ATOM   2013 N N     . THR A 1 413 ? 93.978  109.332 140.025 1.00 89.82  ? 387 THR A N     1 
ATOM   2014 C CA    . THR A 1 413 ? 92.675  109.692 140.543 1.00 101.73 ? 387 THR A CA    1 
ATOM   2015 C C     . THR A 1 413 ? 92.101  110.868 139.745 1.00 101.86 ? 387 THR A C     1 
ATOM   2016 O O     . THR A 1 413 ? 92.771  111.880 139.539 1.00 105.81 ? 387 THR A O     1 
ATOM   2017 C CB    . THR A 1 413 ? 92.810  109.974 142.041 1.00 121.74 ? 387 THR A CB    1 
ATOM   2018 O OG1   . THR A 1 413 ? 93.060  108.676 142.574 1.00 72.92  ? 387 THR A OG1   1 
ATOM   2019 C CG2   . THR A 1 413 ? 91.600  110.669 142.648 1.00 136.10 ? 387 THR A CG2   1 
ATOM   2020 N N     . LYS A 1 414 ? 90.852  110.701 139.301 1.00 99.72  ? 388 LYS A N     1 
ATOM   2021 C CA    . LYS A 1 414 ? 90.017  111.807 138.874 1.00 105.09 ? 388 LYS A CA    1 
ATOM   2022 C C     . LYS A 1 414 ? 88.699  111.648 139.623 1.00 98.20  ? 388 LYS A C     1 
ATOM   2023 O O     . LYS A 1 414 ? 88.465  110.586 140.193 1.00 113.93 ? 388 LYS A O     1 
ATOM   2024 C CB    . LYS A 1 414 ? 90.072  111.706 137.350 1.00 98.02  ? 388 LYS A CB    1 
ATOM   2025 C CG    . LYS A 1 414 ? 89.527  112.879 136.587 1.00 125.39 ? 388 LYS A CG    1 
ATOM   2026 C CD    . LYS A 1 414 ? 90.214  113.032 135.235 1.00 156.86 ? 388 LYS A CD    1 
ATOM   2027 C CE    . LYS A 1 414 ? 89.974  114.386 134.633 1.00 193.29 ? 388 LYS A CE    1 
ATOM   2028 N NZ    . LYS A 1 414 ? 88.551  114.739 134.583 1.00 209.55 ? 388 LYS A NZ    1 
ATOM   2029 N N     . VAL A 1 415 ? 87.903  112.715 139.729 1.00 101.45 ? 389 VAL A N     1 
ATOM   2030 C CA    . VAL A 1 415 ? 86.579  112.614 140.334 1.00 104.16 ? 389 VAL A CA    1 
ATOM   2031 C C     . VAL A 1 415 ? 85.517  112.824 139.248 1.00 104.87 ? 389 VAL A C     1 
ATOM   2032 O O     . VAL A 1 415 ? 85.709  113.615 138.323 1.00 95.32  ? 389 VAL A O     1 
ATOM   2033 C CB    . VAL A 1 415 ? 86.399  113.644 141.456 1.00 114.77 ? 389 VAL A CB    1 
ATOM   2034 C CG1   . VAL A 1 415 ? 86.262  115.058 140.873 1.00 147.81 ? 389 VAL A CG1   1 
ATOM   2035 C CG2   . VAL A 1 415 ? 85.214  113.305 142.355 1.00 104.93 ? 389 VAL A CG2   1 
ATOM   2036 N N     . MET A 1 416 ? 84.367  112.148 139.390 1.00 100.84 ? 390 MET A N     1 
ATOM   2037 C CA    . MET A 1 416 ? 83.424  112.013 138.289 1.00 115.21 ? 390 MET A CA    1 
ATOM   2038 C C     . MET A 1 416 ? 82.250  112.966 138.424 1.00 110.13 ? 390 MET A C     1 
ATOM   2039 O O     . MET A 1 416 ? 81.476  112.842 139.376 1.00 97.74  ? 390 MET A O     1 
ATOM   2040 C CB    . MET A 1 416 ? 82.836  110.604 138.239 1.00 132.91 ? 390 MET A CB    1 
ATOM   2041 C CG    . MET A 1 416 ? 83.497  109.716 137.204 1.00 130.82 ? 390 MET A CG    1 
ATOM   2042 S SD    . MET A 1 416 ? 82.440  108.358 136.683 1.00 117.13 ? 390 MET A SD    1 
ATOM   2043 C CE    . MET A 1 416 ? 82.136  107.865 138.394 1.00 112.46 ? 390 MET A CE    1 
ATOM   2044 N N     . ASN A 1 417 ? 82.089  113.824 137.411 1.00 93.49  ? 391 ASN A N     1 
ATOM   2045 C CA    . ASN A 1 417 ? 81.293  115.024 137.575 1.00 96.98  ? 391 ASN A CA    1 
ATOM   2046 C C     . ASN A 1 417 ? 80.416  115.304 136.352 1.00 99.98  ? 391 ASN A C     1 
ATOM   2047 O O     . ASN A 1 417 ? 80.776  114.967 135.223 1.00 90.49  ? 391 ASN A O     1 
ATOM   2048 C CB    . ASN A 1 417 ? 82.197  116.213 137.823 1.00 111.74 ? 391 ASN A CB    1 
ATOM   2049 C CG    . ASN A 1 417 ? 83.000  116.522 136.588 1.00 147.20 ? 391 ASN A CG    1 
ATOM   2050 O OD1   . ASN A 1 417 ? 82.609  117.388 135.791 1.00 137.52 ? 391 ASN A OD1   1 
ATOM   2051 N ND2   . ASN A 1 417 ? 84.088  115.788 136.394 1.00 165.21 ? 391 ASN A ND2   1 
ATOM   2052 N N     . MET A 1 418 ? 79.271  115.965 136.603 1.00 96.74  ? 392 MET A N     1 
ATOM   2053 C CA    . MET A 1 418 ? 78.185  116.065 135.639 1.00 94.11  ? 392 MET A CA    1 
ATOM   2054 C C     . MET A 1 418 ? 78.499  117.137 134.613 1.00 128.45 ? 392 MET A C     1 
ATOM   2055 O O     . MET A 1 418 ? 77.917  117.162 133.530 1.00 147.18 ? 392 MET A O     1 
ATOM   2056 C CB    . MET A 1 418 ? 76.855  116.397 136.322 1.00 98.90  ? 392 MET A CB    1 
ATOM   2057 C CG    . MET A 1 418 ? 76.335  115.243 137.164 1.00 128.39 ? 392 MET A CG    1 
ATOM   2058 S SD    . MET A 1 418 ? 74.545  115.065 137.229 1.00 148.34 ? 392 MET A SD    1 
ATOM   2059 C CE    . MET A 1 418 ? 74.277  114.834 135.464 1.00 149.15 ? 392 MET A CE    1 
ATOM   2060 N N     . GLU A 1 419 ? 79.434  118.019 134.968 1.00 163.43 ? 393 GLU A N     1 
ATOM   2061 C CA    . GLU A 1 419 ? 79.811  119.123 134.107 1.00 190.17 ? 393 GLU A CA    1 
ATOM   2062 C C     . GLU A 1 419 ? 80.600  118.543 132.938 1.00 185.43 ? 393 GLU A C     1 
ATOM   2063 O O     . GLU A 1 419 ? 80.413  117.380 132.584 1.00 191.50 ? 393 GLU A O     1 
ATOM   2064 C CB    . GLU A 1 419 ? 80.561  120.146 134.963 1.00 225.90 ? 393 GLU A CB    1 
ATOM   2065 C CG    . GLU A 1 419 ? 79.705  120.791 136.053 1.00 253.42 ? 393 GLU A CG    1 
ATOM   2066 C CD    . GLU A 1 419 ? 79.272  119.916 137.225 1.00 243.67 ? 393 GLU A CD    1 
ATOM   2067 O OE1   . GLU A 1 419 ? 78.588  120.450 138.124 1.00 247.10 ? 393 GLU A OE1   1 
ATOM   2068 O OE2   . GLU A 1 419 ? 79.605  118.711 137.254 1.00 204.66 ? 393 GLU A OE2   1 
ATOM   2069 N N     . GLU A 1 420 ? 81.478  119.354 132.342 1.00 189.14 ? 394 GLU A N     1 
ATOM   2070 C CA    . GLU A 1 420 ? 82.397  118.863 131.329 1.00 221.51 ? 394 GLU A CA    1 
ATOM   2071 C C     . GLU A 1 420 ? 81.590  118.203 130.212 1.00 234.45 ? 394 GLU A C     1 
ATOM   2072 O O     . GLU A 1 420 ? 81.198  118.863 129.250 1.00 245.27 ? 394 GLU A O     1 
ATOM   2073 C CB    . GLU A 1 420 ? 83.432  117.955 132.002 1.00 234.57 ? 394 GLU A CB    1 
ATOM   2074 C CG    . GLU A 1 420 ? 84.358  117.218 131.037 1.00 267.70 ? 394 GLU A CG    1 
ATOM   2075 C CD    . GLU A 1 420 ? 85.022  115.985 131.636 1.00 290.23 ? 394 GLU A CD    1 
ATOM   2076 O OE1   . GLU A 1 420 ? 84.832  114.875 131.090 1.00 284.02 ? 394 GLU A OE1   1 
ATOM   2077 O OE2   . GLU A 1 420 ? 85.730  116.132 132.657 1.00 289.22 ? 394 GLU A OE2   1 
ATOM   2078 N N     . SER A 1 421 ? 81.334  116.898 130.354 1.00 231.88 ? 395 SER A N     1 
ATOM   2079 C CA    . SER A 1 421 ? 80.558  116.173 129.368 1.00 236.40 ? 395 SER A CA    1 
ATOM   2080 C C     . SER A 1 421 ? 79.130  116.698 129.418 1.00 260.81 ? 395 SER A C     1 
ATOM   2081 O O     . SER A 1 421 ? 78.528  116.777 130.488 1.00 263.48 ? 395 SER A O     1 
ATOM   2082 C CB    . SER A 1 421 ? 80.619  114.683 129.600 1.00 256.87 ? 395 SER A CB    1 
ATOM   2083 O OG    . SER A 1 421 ? 80.129  113.958 128.478 1.00 255.55 ? 395 SER A OG    1 
ATOM   2084 N N     . THR A 1 422 ? 78.619  117.089 128.249 1.00 280.01 ? 396 THR A N     1 
ATOM   2085 C CA    . THR A 1 422 ? 77.315  117.721 128.153 1.00 295.60 ? 396 THR A CA    1 
ATOM   2086 C C     . THR A 1 422 ? 76.210  116.675 128.327 1.00 280.78 ? 396 THR A C     1 
ATOM   2087 O O     . THR A 1 422 ? 76.461  115.468 128.311 1.00 206.27 ? 396 THR A O     1 
ATOM   2088 C CB    . THR A 1 422 ? 77.224  118.468 126.821 1.00 301.11 ? 396 THR A CB    1 
ATOM   2089 O OG1   . THR A 1 422 ? 75.943  119.091 126.824 1.00 303.60 ? 396 THR A OG1   1 
ATOM   2090 C CG2   . THR A 1 422 ? 77.391  117.564 125.610 1.00 300.19 ? 396 THR A CG2   1 
ATOM   2091 N N     . ASN A 1 423 ? 74.985  117.180 128.528 1.00 277.07 ? 397 ASN A N     1 
ATOM   2092 C CA    . ASN A 1 423 ? 73.772  116.377 128.544 1.00 269.66 ? 397 ASN A CA    1 
ATOM   2093 C C     . ASN A 1 423 ? 73.806  115.397 129.709 1.00 220.83 ? 397 ASN A C     1 
ATOM   2094 O O     . ASN A 1 423 ? 73.600  114.198 129.528 1.00 225.14 ? 397 ASN A O     1 
ATOM   2095 C CB    . ASN A 1 423 ? 73.558  115.637 127.229 1.00 281.39 ? 397 ASN A CB    1 
ATOM   2096 C CG    . ASN A 1 423 ? 73.828  116.524 126.039 1.00 281.34 ? 397 ASN A CG    1 
ATOM   2097 O OD1   . ASN A 1 423 ? 73.576  117.733 126.097 1.00 283.08 ? 397 ASN A OD1   1 
ATOM   2098 N ND2   . ASN A 1 423 ? 74.372  115.956 124.972 1.00 290.70 ? 397 ASN A ND2   1 
ATOM   2099 N N     . GLY A 1 424 ? 74.023  115.936 130.906 1.00 173.51 ? 398 GLY A N     1 
ATOM   2100 C CA    . GLY A 1 424 ? 74.335  115.097 132.040 1.00 178.88 ? 398 GLY A CA    1 
ATOM   2101 C C     . GLY A 1 424 ? 75.586  114.296 131.717 1.00 175.12 ? 398 GLY A C     1 
ATOM   2102 O O     . GLY A 1 424 ? 76.624  114.887 131.419 1.00 175.63 ? 398 GLY A O     1 
ATOM   2103 N N     . SER A 1 425 ? 75.430  112.965 131.671 1.00 165.43 ? 399 SER A N     1 
ATOM   2104 C CA    . SER A 1 425 ? 76.549  112.046 131.576 1.00 127.14 ? 399 SER A CA    1 
ATOM   2105 C C     . SER A 1 425 ? 77.365  112.276 132.844 1.00 100.46 ? 399 SER A C     1 
ATOM   2106 O O     . SER A 1 425 ? 77.891  113.365 133.072 1.00 120.07 ? 399 SER A O     1 
ATOM   2107 C CB    . SER A 1 425 ? 77.376  112.222 130.271 1.00 132.15 ? 399 SER A CB    1 
ATOM   2108 O OG    . SER A 1 425 ? 76.654  112.815 129.190 1.00 120.99 ? 399 SER A OG    1 
ATOM   2109 N N     . LEU A 1 426 ? 77.410  111.288 133.721 1.00 82.10  ? 400 LEU A N     1 
ATOM   2110 C CA    . LEU A 1 426 ? 78.267  111.425 134.882 1.00 75.61  ? 400 LEU A CA    1 
ATOM   2111 C C     . LEU A 1 426 ? 79.662  110.812 134.679 1.00 63.54  ? 400 LEU A C     1 
ATOM   2112 O O     . LEU A 1 426 ? 79.966  109.777 135.240 1.00 68.78  ? 400 LEU A O     1 
ATOM   2113 C CB    . LEU A 1 426 ? 77.478  110.795 136.018 1.00 66.34  ? 400 LEU A CB    1 
ATOM   2114 C CG    . LEU A 1 426 ? 78.234  110.795 137.340 1.00 73.33  ? 400 LEU A CG    1 
ATOM   2115 C CD1   . LEU A 1 426 ? 78.522  112.191 137.783 1.00 84.47  ? 400 LEU A CD1   1 
ATOM   2116 C CD2   . LEU A 1 426 ? 77.462  110.052 138.413 1.00 88.32  ? 400 LEU A CD2   1 
ATOM   2117 N N     . ALA A 1 427 ? 80.557  111.508 133.963 1.00 72.80  ? 401 ALA A N     1 
ATOM   2118 C CA    . ALA A 1 427 ? 81.739  110.902 133.355 1.00 72.62  ? 401 ALA A CA    1 
ATOM   2119 C C     . ALA A 1 427 ? 83.058  111.316 134.011 1.00 80.77  ? 401 ALA A C     1 
ATOM   2120 O O     . ALA A 1 427 ? 83.036  112.068 134.986 1.00 106.62 ? 401 ALA A O     1 
ATOM   2121 C CB    . ALA A 1 427 ? 81.766  111.280 131.913 1.00 75.75  ? 401 ALA A CB    1 
ATOM   2122 N N     . ALA A 1 428 ? 84.186  110.801 133.462 1.00 81.41  ? 402 ALA A N     1 
ATOM   2123 C CA    . ALA A 1 428 ? 85.561  111.115 133.873 1.00 75.59  ? 402 ALA A CA    1 
ATOM   2124 C C     . ALA A 1 428 ? 86.541  110.845 132.734 1.00 77.69  ? 402 ALA A C     1 
ATOM   2125 O O     . ALA A 1 428 ? 86.851  109.690 132.487 1.00 72.62  ? 402 ALA A O     1 
ATOM   2126 C CB    . ALA A 1 428 ? 85.991  110.286 135.066 1.00 54.38  ? 402 ALA A CB    1 
ATOM   2127 N N     . GLU A 1 429 ? 87.049  111.881 132.060 1.00 72.28  ? 403 GLU A N     1 
ATOM   2128 C CA    . GLU A 1 429 ? 87.869  111.652 130.885 1.00 58.06  ? 403 GLU A CA    1 
ATOM   2129 C C     . GLU A 1 429 ? 89.315  111.918 131.213 1.00 61.25  ? 403 GLU A C     1 
ATOM   2130 O O     . GLU A 1 429 ? 89.755  113.055 131.124 1.00 110.21 ? 403 GLU A O     1 
ATOM   2131 C CB    . GLU A 1 429 ? 87.593  112.614 129.740 1.00 71.76  ? 403 GLU A CB    1 
ATOM   2132 C CG    . GLU A 1 429 ? 88.503  112.366 128.539 1.00 98.40  ? 403 GLU A CG    1 
ATOM   2133 C CD    . GLU A 1 429 ? 88.157  113.211 127.315 1.00 166.43 ? 403 GLU A CD    1 
ATOM   2134 O OE1   . GLU A 1 429 ? 87.408  114.221 127.454 1.00 164.43 ? 403 GLU A OE1   1 
ATOM   2135 O OE2   . GLU A 1 429 ? 88.654  112.859 126.212 1.00 208.67 ? 403 GLU A OE2   1 
ATOM   2136 N N     . PHE A 1 430 ? 90.049  110.897 131.627 1.00 71.37  ? 404 PHE A N     1 
ATOM   2137 C CA    . PHE A 1 430 ? 91.491  111.024 131.761 1.00 72.55  ? 404 PHE A CA    1 
ATOM   2138 C C     . PHE A 1 430 ? 92.057  111.411 130.394 1.00 72.48  ? 404 PHE A C     1 
ATOM   2139 O O     . PHE A 1 430 ? 91.835  110.705 129.413 1.00 79.44  ? 404 PHE A O     1 
ATOM   2140 C CB    . PHE A 1 430 ? 92.142  109.736 132.276 1.00 62.18  ? 404 PHE A CB    1 
ATOM   2141 C CG    . PHE A 1 430 ? 91.482  109.208 133.537 1.00 62.10  ? 404 PHE A CG    1 
ATOM   2142 C CD1   . PHE A 1 430 ? 90.244  108.620 133.495 1.00 74.73  ? 404 PHE A CD1   1 
ATOM   2143 C CD2   . PHE A 1 430 ? 92.113  109.239 134.751 1.00 61.89  ? 404 PHE A CD2   1 
ATOM   2144 C CE1   . PHE A 1 430 ? 89.667  108.077 134.634 1.00 83.73  ? 404 PHE A CE1   1 
ATOM   2145 C CE2   . PHE A 1 430 ? 91.533  108.700 135.890 1.00 67.89  ? 404 PHE A CE2   1 
ATOM   2146 C CZ    . PHE A 1 430 ? 90.339  108.068 135.824 1.00 75.87  ? 404 PHE A CZ    1 
ATOM   2147 N N     . ARG A 1 431 ? 92.783  112.535 130.329 1.00 74.54  ? 405 ARG A N     1 
ATOM   2148 C CA    . ARG A 1 431 ? 93.889  112.609 129.383 1.00 82.14  ? 405 ARG A CA    1 
ATOM   2149 C C     . ARG A 1 431 ? 95.196  112.665 130.173 1.00 91.28  ? 405 ARG A C     1 
ATOM   2150 O O     . ARG A 1 431 ? 95.182  112.653 131.414 1.00 88.42  ? 405 ARG A O     1 
ATOM   2151 C CB    . ARG A 1 431 ? 93.680  113.761 128.408 1.00 79.97  ? 405 ARG A CB    1 
ATOM   2152 C CG    . ARG A 1 431 ? 92.279  113.818 127.808 1.00 96.26  ? 405 ARG A CG    1 
ATOM   2153 C CD    . ARG A 1 431 ? 91.755  115.203 127.411 1.00 116.49 ? 405 ARG A CD    1 
ATOM   2154 N NE    . ARG A 1 431 ? 90.914  115.788 128.471 1.00 156.62 ? 405 ARG A NE    1 
ATOM   2155 C CZ    . ARG A 1 431 ? 91.199  115.997 129.778 1.00 172.46 ? 405 ARG A CZ    1 
ATOM   2156 N NH1   . ARG A 1 431 ? 92.419  115.831 130.264 1.00 150.66 ? 405 ARG A NH1   1 
ATOM   2157 N NH2   . ARG A 1 431 ? 90.248  116.419 130.604 1.00 171.69 ? 405 ARG A NH2   1 
ATOM   2158 N N     . HIS A 1 432 ? 96.323  112.725 129.455 1.00 84.27  ? 406 HIS A N     1 
ATOM   2159 C CA    . HIS A 1 432 ? 97.625  112.725 130.124 1.00 111.56 ? 406 HIS A CA    1 
ATOM   2160 C C     . HIS A 1 432 ? 97.734  111.520 131.077 1.00 94.22  ? 406 HIS A C     1 
ATOM   2161 O O     . HIS A 1 432 ? 97.521  111.650 132.284 1.00 106.16 ? 406 HIS A O     1 
ATOM   2162 C CB    . HIS A 1 432 ? 97.899  114.089 130.788 1.00 124.74 ? 406 HIS A CB    1 
ATOM   2163 C CG    . HIS A 1 432 ? 97.394  115.269 130.023 1.00 132.44 ? 406 HIS A CG    1 
ATOM   2164 N ND1   . HIS A 1 432 ? 97.775  115.537 128.725 1.00 150.70 ? 406 HIS A ND1   1 
ATOM   2165 C CD2   . HIS A 1 432 ? 96.479  116.201 130.341 1.00 136.08 ? 406 HIS A CD2   1 
ATOM   2166 C CE1   . HIS A 1 432 ? 97.119  116.607 128.288 1.00 162.28 ? 406 HIS A CE1   1 
ATOM   2167 N NE2   . HIS A 1 432 ? 96.315  117.020 129.249 1.00 139.76 ? 406 HIS A NE2   1 
ATOM   2168 N N     . LEU A 1 433 ? 97.974  110.333 130.493 1.00 81.97  ? 407 LEU A N     1 
ATOM   2169 C CA    . LEU A 1 433 ? 98.327  109.098 131.187 1.00 86.49  ? 407 LEU A CA    1 
ATOM   2170 C C     . LEU A 1 433 ? 99.452  108.524 130.370 1.00 90.72  ? 407 LEU A C     1 
ATOM   2171 O O     . LEU A 1 433 ? 99.417  108.670 129.149 1.00 92.32  ? 407 LEU A O     1 
ATOM   2172 C CB    . LEU A 1 433 ? 97.291  107.977 131.305 1.00 82.89  ? 407 LEU A CB    1 
ATOM   2173 C CG    . LEU A 1 433 ? 96.076  108.307 132.157 1.00 81.81  ? 407 LEU A CG    1 
ATOM   2174 C CD1   . LEU A 1 433 ? 95.137  107.181 132.292 1.00 93.57  ? 407 LEU A CD1   1 
ATOM   2175 C CD2   . LEU A 1 433 ? 96.558  108.656 133.496 1.00 91.86  ? 407 LEU A CD2   1 
ATOM   2176 N N     . GLN A 1 434 ? 100.374 107.830 131.045 1.00 79.11  ? 408 GLN A N     1 
ATOM   2177 C CA    . GLN A 1 434 ? 101.581 107.324 130.399 1.00 73.73  ? 408 GLN A CA    1 
ATOM   2178 C C     . GLN A 1 434 ? 102.022 105.987 131.004 1.00 65.01  ? 408 GLN A C     1 
ATOM   2179 O O     . GLN A 1 434 ? 101.865 105.679 132.189 1.00 66.18  ? 408 GLN A O     1 
ATOM   2180 C CB    . GLN A 1 434 ? 102.713 108.317 130.633 1.00 85.64  ? 408 GLN A CB    1 
ATOM   2181 C CG    . GLN A 1 434 ? 102.885 109.409 129.593 1.00 105.00 ? 408 GLN A CG    1 
ATOM   2182 C CD    . GLN A 1 434 ? 104.163 110.174 129.838 1.00 128.15 ? 408 GLN A CD    1 
ATOM   2183 O OE1   . GLN A 1 434 ? 104.764 110.078 130.916 1.00 137.14 ? 408 GLN A OE1   1 
ATOM   2184 N NE2   . GLN A 1 434 ? 104.596 110.930 128.837 1.00 133.75 ? 408 GLN A NE2   1 
ATOM   2185 N N     . LEU A 1 435 ? 102.652 105.171 130.198 1.00 71.37  ? 409 LEU A N     1 
ATOM   2186 C CA    . LEU A 1 435 ? 103.224 103.970 130.762 1.00 78.67  ? 409 LEU A CA    1 
ATOM   2187 C C     . LEU A 1 435 ? 104.735 104.119 130.829 1.00 84.68  ? 409 LEU A C     1 
ATOM   2188 O O     . LEU A 1 435 ? 105.350 104.827 130.032 1.00 106.59 ? 409 LEU A O     1 
ATOM   2189 C CB    . LEU A 1 435 ? 102.766 102.851 129.839 1.00 85.32  ? 409 LEU A CB    1 
ATOM   2190 C CG    . LEU A 1 435 ? 101.562 102.027 130.307 1.00 85.83  ? 409 LEU A CG    1 
ATOM   2191 C CD1   . LEU A 1 435 ? 100.579 102.741 131.179 1.00 77.91  ? 409 LEU A CD1   1 
ATOM   2192 C CD2   . LEU A 1 435 ? 100.831 101.494 129.097 1.00 91.40  ? 409 LEU A CD2   1 
ATOM   2193 N N     . LYS A 1 436 ? 105.325 103.477 131.822 1.00 92.67  ? 410 LYS A N     1 
ATOM   2194 C CA    . LYS A 1 436 ? 106.770 103.348 131.857 1.00 104.67 ? 410 LYS A CA    1 
ATOM   2195 C C     . LYS A 1 436 ? 107.119 101.925 132.310 1.00 82.81  ? 410 LYS A C     1 
ATOM   2196 O O     . LYS A 1 436 ? 106.427 101.308 133.127 1.00 68.40  ? 410 LYS A O     1 
ATOM   2197 C CB    . LYS A 1 436 ? 107.326 104.534 132.656 1.00 109.29 ? 410 LYS A CB    1 
ATOM   2198 C CG    . LYS A 1 436 ? 108.671 104.235 133.307 1.00 150.03 ? 410 LYS A CG    1 
ATOM   2199 C CD    . LYS A 1 436 ? 109.356 105.407 134.001 1.00 167.88 ? 410 LYS A CD    1 
ATOM   2200 C CE    . LYS A 1 436 ? 109.725 106.513 133.064 1.00 171.77 ? 410 LYS A CE    1 
ATOM   2201 N NZ    . LYS A 1 436 ? 110.624 107.457 133.733 1.00 177.42 ? 410 LYS A NZ    1 
ATOM   2202 N N     . GLU A 1 437 ? 108.148 101.340 131.710 1.00 67.99  ? 411 GLU A N     1 
ATOM   2203 C CA    . GLU A 1 437 ? 108.422 99.967  132.083 1.00 70.55  ? 411 GLU A CA    1 
ATOM   2204 C C     . GLU A 1 437 ? 109.032 100.054 133.466 1.00 97.06  ? 411 GLU A C     1 
ATOM   2205 O O     . GLU A 1 437 ? 109.492 101.115 133.887 1.00 127.93 ? 411 GLU A O     1 
ATOM   2206 C CB    . GLU A 1 437 ? 109.358 99.280  131.097 1.00 73.25  ? 411 GLU A CB    1 
ATOM   2207 C CG    . GLU A 1 437 ? 109.573 97.800  131.390 1.00 94.33  ? 411 GLU A CG    1 
ATOM   2208 C CD    . GLU A 1 437 ? 110.305 96.967  130.324 1.00 130.71 ? 411 GLU A CD    1 
ATOM   2209 O OE1   . GLU A 1 437 ? 110.665 97.514  129.257 1.00 127.54 ? 411 GLU A OE1   1 
ATOM   2210 O OE2   . GLU A 1 437 ? 110.514 95.741  130.547 1.00 141.76 ? 411 GLU A OE2   1 
ATOM   2211 N N     . GLN A 1 438 ? 108.994 98.941  134.177 1.00 111.01 ? 412 GLN A N     1 
ATOM   2212 C CA    . GLN A 1 438 ? 109.646 98.826  135.464 1.00 112.91 ? 412 GLN A CA    1 
ATOM   2213 C C     . GLN A 1 438 ? 110.891 97.988  135.188 1.00 132.31 ? 412 GLN A C     1 
ATOM   2214 O O     . GLN A 1 438 ? 110.847 96.758  135.193 1.00 131.07 ? 412 GLN A O     1 
ATOM   2215 C CB    . GLN A 1 438 ? 108.566 98.172  136.325 1.00 123.83 ? 412 GLN A CB    1 
ATOM   2216 C CG    . GLN A 1 438 ? 108.548 98.478  137.815 1.00 123.13 ? 412 GLN A CG    1 
ATOM   2217 C CD    . GLN A 1 438 ? 107.453 97.660  138.471 1.00 159.55 ? 412 GLN A CD    1 
ATOM   2218 O OE1   . GLN A 1 438 ? 106.397 98.179  138.851 1.00 195.78 ? 412 GLN A OE1   1 
ATOM   2219 N NE2   . GLN A 1 438 ? 107.644 96.347  138.522 1.00 158.17 ? 412 GLN A NE2   1 
ATOM   2220 N N     . LYS A 1 439 ? 111.968 98.666  134.798 1.00 158.91 ? 413 LYS A N     1 
ATOM   2221 C CA    . LYS A 1 439 ? 113.246 98.002  134.655 1.00 168.77 ? 413 LYS A CA    1 
ATOM   2222 C C     . LYS A 1 439 ? 113.681 97.697  136.077 1.00 208.19 ? 413 LYS A C     1 
ATOM   2223 O O     . LYS A 1 439 ? 113.844 98.618  136.883 1.00 207.35 ? 413 LYS A O     1 
ATOM   2224 C CB    . LYS A 1 439 ? 114.291 98.885  133.963 1.00 192.55 ? 413 LYS A CB    1 
ATOM   2225 C CG    . LYS A 1 439 ? 113.936 99.497  132.605 1.00 180.53 ? 413 LYS A CG    1 
ATOM   2226 C CD    . LYS A 1 439 ? 113.935 98.527  131.428 1.00 179.07 ? 413 LYS A CD    1 
ATOM   2227 C CE    . LYS A 1 439 ? 114.050 99.276  130.131 1.00 167.94 ? 413 LYS A CE    1 
ATOM   2228 N NZ    . LYS A 1 439 ? 113.862 98.502  128.892 1.00 145.28 ? 413 LYS A NZ    1 
ATOM   2229 N N     . ASN A 1 440 ? 113.760 96.405  136.393 1.00 230.90 ? 414 ASN A N     1 
ATOM   2230 C CA    . ASN A 1 440 ? 114.243 95.975  137.694 1.00 287.14 ? 414 ASN A CA    1 
ATOM   2231 C C     . ASN A 1 440 ? 114.931 94.625  137.513 1.00 308.52 ? 414 ASN A C     1 
ATOM   2232 O O     . ASN A 1 440 ? 114.910 93.795  138.421 1.00 357.12 ? 414 ASN A O     1 
ATOM   2233 C CB    . ASN A 1 440 ? 113.125 95.994  138.738 1.00 255.22 ? 414 ASN A CB    1 
ATOM   2234 C CG    . ASN A 1 440 ? 112.021 95.002  138.445 1.00 208.16 ? 414 ASN A CG    1 
ATOM   2235 O OD1   . ASN A 1 440 ? 111.624 94.841  137.286 1.00 220.03 ? 414 ASN A OD1   1 
ATOM   2236 N ND2   . ASN A 1 440 ? 111.527 94.315  139.463 1.00 196.01 ? 414 ASN A ND2   1 
ATOM   2237 N N     . ALA A 1 441 ? 115.570 94.435  136.347 1.00 231.59 ? 415 ALA A N     1 
ATOM   2238 C CA    . ALA A 1 441 ? 115.868 93.094  135.877 1.00 212.87 ? 415 ALA A CA    1 
ATOM   2239 C C     . ALA A 1 441 ? 114.617 92.253  136.131 1.00 219.59 ? 415 ALA A C     1 
ATOM   2240 O O     . ALA A 1 441 ? 113.590 92.508  135.506 1.00 170.29 ? 415 ALA A O     1 
ATOM   2241 C CB    . ALA A 1 441 ? 117.118 92.546  136.550 1.00 202.92 ? 415 ALA A CB    1 
ATOM   2242 N N     . GLY A 1 442 ? 114.668 91.330  137.105 1.00 246.24 ? 416 GLY A N     1 
ATOM   2243 C CA    . GLY A 1 442 ? 113.479 90.627  137.563 1.00 271.13 ? 416 GLY A CA    1 
ATOM   2244 C C     . GLY A 1 442 ? 113.069 89.523  136.594 1.00 307.67 ? 416 GLY A C     1 
ATOM   2245 O O     . GLY A 1 442 ? 113.403 88.359  136.807 1.00 326.48 ? 416 GLY A O     1 
ATOM   2246 N N     . THR A 1 443 ? 112.336 89.912  135.539 1.00 323.90 ? 417 THR A N     1 
ATOM   2247 C CA    . THR A 1 443 ? 111.937 89.002  134.473 1.00 314.93 ? 417 THR A CA    1 
ATOM   2248 C C     . THR A 1 443 ? 113.186 88.575  133.709 1.00 242.30 ? 417 THR A C     1 
ATOM   2249 O O     . THR A 1 443 ? 113.250 87.466  133.179 1.00 176.68 ? 417 THR A O     1 
ATOM   2250 C CB    . THR A 1 443 ? 110.929 89.657  133.524 1.00 347.65 ? 417 THR A CB    1 
ATOM   2251 O OG1   . THR A 1 443 ? 111.658 90.564  132.701 1.00 333.05 ? 417 THR A OG1   1 
ATOM   2252 C CG2   . THR A 1 443 ? 109.803 90.379  134.244 1.00 366.98 ? 417 THR A CG2   1 
ATOM   2253 N N     . ARG A 1 444 ? 114.152 89.503  133.651 1.00 250.32 ? 418 ARG A N     1 
ATOM   2254 C CA    . ARG A 1 444 ? 115.423 89.298  132.984 1.00 273.33 ? 418 ARG A CA    1 
ATOM   2255 C C     . ARG A 1 444 ? 115.166 89.184  131.483 1.00 265.98 ? 418 ARG A C     1 
ATOM   2256 O O     . ARG A 1 444 ? 116.010 88.674  130.753 1.00 329.02 ? 418 ARG A O     1 
ATOM   2257 C CB    . ARG A 1 444 ? 116.138 88.076  133.574 1.00 313.61 ? 418 ARG A CB    1 
ATOM   2258 C CG    . ARG A 1 444 ? 117.625 87.962  133.267 1.00 346.37 ? 418 ARG A CG    1 
ATOM   2259 C CD    . ARG A 1 444 ? 118.088 86.511  133.300 1.00 375.03 ? 418 ARG A CD    1 
ATOM   2260 N NE    . ARG A 1 444 ? 118.002 85.931  134.646 1.00 422.72 ? 418 ARG A NE    1 
ATOM   2261 C CZ    . ARG A 1 444 ? 117.107 85.045  135.092 1.00 458.59 ? 418 ARG A CZ    1 
ATOM   2262 N NH1   . ARG A 1 444 ? 116.096 84.643  134.336 1.00 455.36 ? 418 ARG A NH1   1 
ATOM   2263 N NH2   . ARG A 1 444 ? 117.219 84.574  136.324 1.00 475.47 ? 418 ARG A NH2   1 
ATOM   2264 N N     . THR A 1 445 ? 113.989 89.649  131.040 1.00 212.82 ? 419 THR A N     1 
ATOM   2265 C CA    . THR A 1 445 ? 113.674 89.768  129.626 1.00 213.97 ? 419 THR A CA    1 
ATOM   2266 C C     . THR A 1 445 ? 114.078 88.498  128.876 1.00 163.78 ? 419 THR A C     1 
ATOM   2267 O O     . THR A 1 445 ? 114.642 88.572  127.787 1.00 160.47 ? 419 THR A O     1 
ATOM   2268 C CB    . THR A 1 445 ? 114.387 91.012  129.087 1.00 265.64 ? 419 THR A CB    1 
ATOM   2269 O OG1   . THR A 1 445 ? 113.916 92.076  129.910 1.00 257.06 ? 419 THR A OG1   1 
ATOM   2270 C CG2   . THR A 1 445 ? 114.084 91.309  127.627 1.00 291.50 ? 419 THR A CG2   1 
ATOM   2271 N N     . ASN A 1 446 ? 113.783 87.327  129.445 1.00 130.53 ? 420 ASN A N     1 
ATOM   2272 C CA    . ASN A 1 446 ? 113.961 86.096  128.694 1.00 143.87 ? 420 ASN A CA    1 
ATOM   2273 C C     . ASN A 1 446 ? 113.301 86.295  127.322 1.00 147.73 ? 420 ASN A C     1 
ATOM   2274 O O     . ASN A 1 446 ? 112.092 86.509  127.237 1.00 169.22 ? 420 ASN A O     1 
ATOM   2275 C CB    . ASN A 1 446 ? 113.439 84.896  129.484 1.00 145.37 ? 420 ASN A CB    1 
ATOM   2276 C CG    . ASN A 1 446 ? 113.889 83.568  128.910 1.00 182.17 ? 420 ASN A CG    1 
ATOM   2277 O OD1   . ASN A 1 446 ? 113.859 83.362  127.686 1.00 143.38 ? 420 ASN A OD1   1 
ATOM   2278 N ND2   . ASN A 1 446 ? 114.320 82.655  129.774 1.00 195.51 ? 420 ASN A ND2   1 
ATOM   2279 N N     . GLU A 1 447 ? 114.114 86.295  126.260 1.00 127.25 ? 421 GLU A N     1 
ATOM   2280 C CA    . GLU A 1 447 ? 113.630 86.348  124.887 1.00 147.02 ? 421 GLU A CA    1 
ATOM   2281 C C     . GLU A 1 447 ? 113.576 84.933  124.298 1.00 175.56 ? 421 GLU A C     1 
ATOM   2282 O O     . GLU A 1 447 ? 113.365 84.768  123.096 1.00 198.99 ? 421 GLU A O     1 
ATOM   2283 C CB    . GLU A 1 447 ? 114.543 87.208  124.005 1.00 171.31 ? 421 GLU A CB    1 
ATOM   2284 C CG    . GLU A 1 447 ? 114.126 88.666  123.813 1.00 163.77 ? 421 GLU A CG    1 
ATOM   2285 C CD    . GLU A 1 447 ? 115.250 89.542  123.243 1.00 204.53 ? 421 GLU A CD    1 
ATOM   2286 O OE1   . GLU A 1 447 ? 116.435 89.225  123.507 1.00 216.49 ? 421 GLU A OE1   1 
ATOM   2287 O OE2   . GLU A 1 447 ? 114.977 90.525  122.505 1.00 167.70 ? 421 GLU A OE2   1 
ATOM   2288 N N     . GLY A 1 448 ? 113.785 83.907  125.137 1.00 165.68 ? 422 GLY A N     1 
ATOM   2289 C CA    . GLY A 1 448 ? 113.343 82.559  124.819 1.00 169.64 ? 422 GLY A CA    1 
ATOM   2290 C C     . GLY A 1 448 ? 112.194 82.122  125.732 1.00 187.90 ? 422 GLY A C     1 
ATOM   2291 O O     . GLY A 1 448 ? 112.413 81.245  126.565 1.00 150.43 ? 422 GLY A O     1 
ATOM   2292 N N     . PRO A 1 449 ? 110.972 82.735  125.641 1.00 225.89 ? 423 PRO A N     1 
ATOM   2293 C CA    . PRO A 1 449 ? 109.806 82.393  126.462 1.00 185.23 ? 423 PRO A CA    1 
ATOM   2294 C C     . PRO A 1 449 ? 108.652 81.902  125.592 1.00 169.93 ? 423 PRO A C     1 
ATOM   2295 O O     . PRO A 1 449 ? 108.896 81.228  124.588 1.00 181.28 ? 423 PRO A O     1 
ATOM   2296 C CB    . PRO A 1 449 ? 109.554 83.792  126.999 1.00 179.96 ? 423 PRO A CB    1 
ATOM   2297 C CG    . PRO A 1 449 ? 109.599 84.614  125.716 1.00 249.01 ? 423 PRO A CG    1 
ATOM   2298 C CD    . PRO A 1 449 ? 110.613 83.889  124.798 1.00 258.83 ? 423 PRO A CD    1 
ATOM   2299 N N     . LEU A 1 450 ? 107.411 82.285  125.937 1.00 114.58 ? 424 LEU A N     1 
ATOM   2300 C CA    . LEU A 1 450 ? 106.271 81.701  125.254 1.00 109.73 ? 424 LEU A CA    1 
ATOM   2301 C C     . LEU A 1 450 ? 105.840 82.528  124.057 1.00 121.57 ? 424 LEU A C     1 
ATOM   2302 O O     . LEU A 1 450 ? 105.629 81.953  122.997 1.00 130.49 ? 424 LEU A O     1 
ATOM   2303 C CB    . LEU A 1 450 ? 105.149 81.506  126.247 1.00 133.94 ? 424 LEU A CB    1 
ATOM   2304 C CG    . LEU A 1 450 ? 105.377 80.326  127.199 1.00 228.82 ? 424 LEU A CG    1 
ATOM   2305 C CD1   . LEU A 1 450 ? 105.815 79.044  126.454 1.00 225.52 ? 424 LEU A CD1   1 
ATOM   2306 C CD2   . LEU A 1 450 ? 106.366 80.702  128.309 1.00 249.83 ? 424 LEU A CD2   1 
ATOM   2307 N N     . ILE A 1 451 ? 105.764 83.859  124.225 1.00 127.83 ? 425 ILE A N     1 
ATOM   2308 C CA    . ILE A 1 451 ? 105.122 84.750  123.263 1.00 97.60  ? 425 ILE A CA    1 
ATOM   2309 C C     . ILE A 1 451 ? 105.913 86.052  123.111 1.00 85.29  ? 425 ILE A C     1 
ATOM   2310 O O     . ILE A 1 451 ? 106.250 86.654  124.144 1.00 85.43  ? 425 ILE A O     1 
ATOM   2311 C CB    . ILE A 1 451 ? 103.692 85.058  123.757 1.00 119.57 ? 425 ILE A CB    1 
ATOM   2312 C CG1   . ILE A 1 451 ? 103.646 85.484  125.210 1.00 97.04  ? 425 ILE A CG1   1 
ATOM   2313 C CG2   . ILE A 1 451 ? 102.717 83.899  123.537 1.00 146.37 ? 425 ILE A CG2   1 
ATOM   2314 C CD1   . ILE A 1 451 ? 102.212 85.653  125.669 1.00 86.71  ? 425 ILE A CD1   1 
ATOM   2315 N N     . VAL A 1 452 ? 106.108 86.529  121.852 1.00 64.36  ? 426 VAL A N     1 
ATOM   2316 C CA    . VAL A 1 452 ? 106.710 87.841  121.520 1.00 56.14  ? 426 VAL A CA    1 
ATOM   2317 C C     . VAL A 1 452 ? 105.885 88.949  122.165 1.00 50.52  ? 426 VAL A C     1 
ATOM   2318 O O     . VAL A 1 452 ? 104.818 88.602  122.620 1.00 100.77 ? 426 VAL A O     1 
ATOM   2319 C CB    . VAL A 1 452 ? 106.757 88.010  119.978 1.00 79.83  ? 426 VAL A CB    1 
ATOM   2320 C CG1   . VAL A 1 452 ? 107.336 86.795  119.276 1.00 126.31 ? 426 VAL A CG1   1 
ATOM   2321 C CG2   . VAL A 1 452 ? 105.430 88.261  119.263 1.00 76.35  ? 426 VAL A CG2   1 
ATOM   2322 N N     . THR A 1 453 ? 106.178 90.264  122.084 1.00 58.12  ? 427 THR A N     1 
ATOM   2323 C CA    . THR A 1 453 ? 105.215 91.357  122.463 1.00 64.93  ? 427 THR A CA    1 
ATOM   2324 C C     . THR A 1 453 ? 103.941 91.521  121.519 1.00 81.76  ? 427 THR A C     1 
ATOM   2325 O O     . THR A 1 453 ? 103.730 92.358  120.539 1.00 41.40  ? 427 THR A O     1 
ATOM   2326 C CB    . THR A 1 453 ? 106.120 92.572  122.740 1.00 76.00  ? 427 THR A CB    1 
ATOM   2327 O OG1   . THR A 1 453 ? 107.301 92.806  121.962 1.00 69.75  ? 427 THR A OG1   1 
ATOM   2328 C CG2   . THR A 1 453 ? 107.081 92.325  123.881 1.00 79.43  ? 427 THR A CG2   1 
ATOM   2329 N N     . GLU A 1 454 ? 103.191 90.406  121.730 1.00 97.21  ? 428 GLU A N     1 
ATOM   2330 C CA    . GLU A 1 454 ? 101.754 90.135  121.745 1.00 83.68  ? 428 GLU A CA    1 
ATOM   2331 C C     . GLU A 1 454 ? 101.396 89.363  123.034 1.00 66.13  ? 428 GLU A C     1 
ATOM   2332 O O     . GLU A 1 454 ? 100.927 88.227  123.010 1.00 46.82  ? 428 GLU A O     1 
ATOM   2333 C CB    . GLU A 1 454 ? 101.298 88.999  120.849 1.00 67.39  ? 428 GLU A CB    1 
ATOM   2334 C CG    . GLU A 1 454 ? 102.044 87.701  121.136 1.00 51.89  ? 428 GLU A CG    1 
ATOM   2335 C CD    . GLU A 1 454 ? 101.855 86.722  119.977 1.00 92.71  ? 428 GLU A CD    1 
ATOM   2336 O OE1   . GLU A 1 454 ? 100.713 86.777  119.392 1.00 84.21  ? 428 GLU A OE1   1 
ATOM   2337 O OE2   . GLU A 1 454 ? 102.795 85.896  119.667 1.00 92.72  ? 428 GLU A OE2   1 
ATOM   2338 N N     . GLU A 1 455 ? 101.736 89.970  124.166 1.00 51.35  ? 429 GLU A N     1 
ATOM   2339 C CA    . GLU A 1 455 ? 101.065 89.697  125.403 1.00 64.28  ? 429 GLU A CA    1 
ATOM   2340 C C     . GLU A 1 455 ? 99.993  90.764  125.601 1.00 60.49  ? 429 GLU A C     1 
ATOM   2341 O O     . GLU A 1 455 ? 100.222 91.914  125.280 1.00 95.21  ? 429 GLU A O     1 
ATOM   2342 C CB    . GLU A 1 455 ? 102.179 89.627  126.449 1.00 80.37  ? 429 GLU A CB    1 
ATOM   2343 C CG    . GLU A 1 455 ? 102.880 90.962  126.673 1.00 95.45  ? 429 GLU A CG    1 
ATOM   2344 C CD    . GLU A 1 455 ? 104.111 90.944  127.584 1.00 108.49 ? 429 GLU A CD    1 
ATOM   2345 O OE1   . GLU A 1 455 ? 105.023 90.078  127.392 1.00 112.33 ? 429 GLU A OE1   1 
ATOM   2346 O OE2   . GLU A 1 455 ? 104.177 91.862  128.452 1.00 72.09  ? 429 GLU A OE2   1 
ATOM   2347 N N     . LEU A 1 456 ? 98.840  90.393  126.157 1.00 73.45  ? 430 LEU A N     1 
ATOM   2348 C CA    . LEU A 1 456 ? 97.800  91.356  126.480 1.00 64.60  ? 430 LEU A CA    1 
ATOM   2349 C C     . LEU A 1 456 ? 97.844  91.683  127.965 1.00 57.11  ? 430 LEU A C     1 
ATOM   2350 O O     . LEU A 1 456 ? 98.164  90.841  128.785 1.00 74.54  ? 430 LEU A O     1 
ATOM   2351 C CB    . LEU A 1 456 ? 96.461  90.830  125.999 1.00 54.86  ? 430 LEU A CB    1 
ATOM   2352 C CG    . LEU A 1 456 ? 96.584  90.349  124.544 1.00 65.80  ? 430 LEU A CG    1 
ATOM   2353 C CD1   . LEU A 1 456 ? 96.203  88.911  124.462 1.00 69.81  ? 430 LEU A CD1   1 
ATOM   2354 C CD2   . LEU A 1 456 ? 95.773  91.050  123.528 1.00 74.74  ? 430 LEU A CD2   1 
ATOM   2355 N N     . HIS A 1 457 ? 97.622  92.966  128.233 1.00 51.94  ? 431 HIS A N     1 
ATOM   2356 C CA    . HIS A 1 457 ? 97.677  93.587  129.531 1.00 56.34  ? 431 HIS A CA    1 
ATOM   2357 C C     . HIS A 1 457 ? 96.404  94.390  129.775 1.00 59.05  ? 431 HIS A C     1 
ATOM   2358 O O     . HIS A 1 457 ? 95.884  94.917  128.802 1.00 64.36  ? 431 HIS A O     1 
ATOM   2359 C CB    . HIS A 1 457 ? 98.713  94.709  129.447 1.00 61.13  ? 431 HIS A CB    1 
ATOM   2360 C CG    . HIS A 1 457 ? 100.080 94.195  129.335 1.00 58.51  ? 431 HIS A CG    1 
ATOM   2361 N ND1   . HIS A 1 457 ? 101.026 94.396  130.300 1.00 63.91  ? 431 HIS A ND1   1 
ATOM   2362 C CD2   . HIS A 1 457 ? 100.661 93.501  128.361 1.00 82.46  ? 431 HIS A CD2   1 
ATOM   2363 C CE1   . HIS A 1 457 ? 102.141 93.787  129.917 1.00 90.94  ? 431 HIS A CE1   1 
ATOM   2364 N NE2   . HIS A 1 457 ? 101.948 93.261  128.726 1.00 84.93  ? 431 HIS A NE2   1 
ATOM   2365 N N     . SER A 1 458 ? 96.005  94.644  131.032 1.00 52.36  ? 432 SER A N     1 
ATOM   2366 C CA    . SER A 1 458 ? 94.703  95.257  131.239 1.00 65.79  ? 432 SER A CA    1 
ATOM   2367 C C     . SER A 1 458 ? 94.677  96.459  132.193 1.00 56.51  ? 432 SER A C     1 
ATOM   2368 O O     . SER A 1 458 ? 94.861  96.287  133.382 1.00 70.99  ? 432 SER A O     1 
ATOM   2369 C CB    . SER A 1 458 ? 93.701  94.196  131.671 1.00 70.04  ? 432 SER A CB    1 
ATOM   2370 O OG    . SER A 1 458 ? 93.842  93.851  133.047 1.00 74.90  ? 432 SER A OG    1 
ATOM   2371 N N     . LEU A 1 459 ? 94.193  97.611  131.730 1.00 48.18  ? 433 LEU A N     1 
ATOM   2372 C CA    . LEU A 1 459 ? 93.809  98.692  132.619 1.00 50.91  ? 433 LEU A CA    1 
ATOM   2373 C C     . LEU A 1 459 ? 92.607  98.296  133.422 1.00 55.09  ? 433 LEU A C     1 
ATOM   2374 O O     . LEU A 1 459 ? 91.704  97.699  132.866 1.00 78.69  ? 433 LEU A O     1 
ATOM   2375 C CB    . LEU A 1 459 ? 93.396  100.013 131.986 1.00 60.54  ? 433 LEU A CB    1 
ATOM   2376 C CG    . LEU A 1 459 ? 94.571  100.925 131.667 1.00 71.44  ? 433 LEU A CG    1 
ATOM   2377 C CD1   . LEU A 1 459 ? 95.575  100.288 130.699 1.00 89.52  ? 433 LEU A CD1   1 
ATOM   2378 C CD2   . LEU A 1 459 ? 93.904  102.108 131.118 1.00 71.87  ? 433 LEU A CD2   1 
ATOM   2379 N N     . SER A 1 460 ? 92.563  98.821  134.645 1.00 66.70  ? 434 SER A N     1 
ATOM   2380 C CA    . SER A 1 460 ? 91.433  98.667  135.534 1.00 70.67  ? 434 SER A CA    1 
ATOM   2381 C C     . SER A 1 460 ? 91.023  99.994  136.178 1.00 63.12  ? 434 SER A C     1 
ATOM   2382 O O     . SER A 1 460 ? 91.855  100.816 136.517 1.00 79.81  ? 434 SER A O     1 
ATOM   2383 C CB    . SER A 1 460 ? 91.779  97.677  136.568 1.00 62.74  ? 434 SER A CB    1 
ATOM   2384 O OG    . SER A 1 460 ? 90.594  97.393  137.310 1.00 84.93  ? 434 SER A OG    1 
ATOM   2385 N N     . PHE A 1 461 ? 89.739  100.191 136.408 1.00 55.36  ? 435 PHE A N     1 
ATOM   2386 C CA    . PHE A 1 461 ? 89.296  101.378 137.110 1.00 55.68  ? 435 PHE A CA    1 
ATOM   2387 C C     . PHE A 1 461 ? 88.571  100.955 138.376 1.00 64.54  ? 435 PHE A C     1 
ATOM   2388 O O     . PHE A 1 461 ? 87.971  99.893  138.418 1.00 89.02  ? 435 PHE A O     1 
ATOM   2389 C CB    . PHE A 1 461 ? 88.379  102.180 136.196 1.00 53.62  ? 435 PHE A CB    1 
ATOM   2390 C CG    . PHE A 1 461 ? 89.106  102.485 134.917 1.00 50.03  ? 435 PHE A CG    1 
ATOM   2391 C CD1   . PHE A 1 461 ? 89.232  101.516 133.958 1.00 63.56  ? 435 PHE A CD1   1 
ATOM   2392 C CD2   . PHE A 1 461 ? 89.817  103.659 134.780 1.00 61.13  ? 435 PHE A CD2   1 
ATOM   2393 C CE1   . PHE A 1 461 ? 90.007  101.741 132.833 1.00 78.47  ? 435 PHE A CE1   1 
ATOM   2394 C CE2   . PHE A 1 461 ? 90.590  103.890 133.640 1.00 73.20  ? 435 PHE A CE2   1 
ATOM   2395 C CZ    . PHE A 1 461 ? 90.654  102.938 132.654 1.00 77.32  ? 435 PHE A CZ    1 
ATOM   2396 N N     . GLU A 1 462 ? 88.635  101.787 139.409 1.00 71.29  ? 436 GLU A N     1 
ATOM   2397 C CA    . GLU A 1 462 ? 88.048  101.438 140.687 1.00 70.17  ? 436 GLU A CA    1 
ATOM   2398 C C     . GLU A 1 462 ? 87.469  102.688 141.309 1.00 77.65  ? 436 GLU A C     1 
ATOM   2399 O O     . GLU A 1 462 ? 87.738  103.795 140.844 1.00 91.07  ? 436 GLU A O     1 
ATOM   2400 C CB    . GLU A 1 462 ? 89.117  100.792 141.535 1.00 74.59  ? 436 GLU A CB    1 
ATOM   2401 C CG    . GLU A 1 462 ? 88.530  99.687  142.394 1.00 122.40 ? 436 GLU A CG    1 
ATOM   2402 C CD    . GLU A 1 462 ? 89.414  98.439  142.346 1.00 175.53 ? 436 GLU A CD    1 
ATOM   2403 O OE1   . GLU A 1 462 ? 90.446  98.454  141.614 1.00 133.99 ? 436 GLU A OE1   1 
ATOM   2404 O OE2   . GLU A 1 462 ? 89.067  97.438  143.031 1.00 192.61 ? 436 GLU A OE2   1 
ATOM   2405 N N     . THR A 1 463 ? 86.585  102.503 142.281 1.00 91.73  ? 437 THR A N     1 
ATOM   2406 C CA    . THR A 1 463 ? 85.962  103.658 142.919 1.00 128.05 ? 437 THR A CA    1 
ATOM   2407 C C     . THR A 1 463 ? 85.061  103.133 144.022 1.00 102.96 ? 437 THR A C     1 
ATOM   2408 O O     . THR A 1 463 ? 85.196  101.949 144.358 1.00 94.44  ? 437 THR A O     1 
ATOM   2409 C CB    . THR A 1 463 ? 85.220  104.593 141.952 1.00 137.39 ? 437 THR A CB    1 
ATOM   2410 O OG1   . THR A 1 463 ? 84.469  105.411 142.846 1.00 157.41 ? 437 THR A OG1   1 
ATOM   2411 C CG2   . THR A 1 463 ? 84.260  103.918 140.990 1.00 148.69 ? 437 THR A CG2   1 
ATOM   2412 N N     . GLN A 1 464 ? 84.222  104.020 144.599 1.00 71.14  ? 438 GLN A N     1 
ATOM   2413 C CA    . GLN A 1 464 ? 83.360  103.581 145.685 1.00 79.98  ? 438 GLN A CA    1 
ATOM   2414 C C     . GLN A 1 464 ? 82.297  104.576 146.081 1.00 64.30  ? 438 GLN A C     1 
ATOM   2415 O O     . GLN A 1 464 ? 82.609  105.740 146.319 1.00 98.39  ? 438 GLN A O     1 
ATOM   2416 C CB    . GLN A 1 464 ? 84.132  103.451 146.989 1.00 100.92 ? 438 GLN A CB    1 
ATOM   2417 C CG    . GLN A 1 464 ? 83.288  102.951 148.154 1.00 94.16  ? 438 GLN A CG    1 
ATOM   2418 C CD    . GLN A 1 464 ? 84.182  102.350 149.210 1.00 135.24 ? 438 GLN A CD    1 
ATOM   2419 O OE1   . GLN A 1 464 ? 85.312  102.818 149.436 1.00 134.22 ? 438 GLN A OE1   1 
ATOM   2420 N NE2   . GLN A 1 464 ? 83.705  101.265 149.805 1.00 157.05 ? 438 GLN A NE2   1 
ATOM   2421 N N     . LEU A 1 465 ? 81.059  104.104 146.257 1.00 74.95  ? 439 LEU A N     1 
ATOM   2422 C CA    . LEU A 1 465 ? 79.935  105.035 146.371 1.00 93.05  ? 439 LEU A CA    1 
ATOM   2423 C C     . LEU A 1 465 ? 79.522  105.045 147.811 1.00 98.11  ? 439 LEU A C     1 
ATOM   2424 O O     . LEU A 1 465 ? 78.890  104.076 148.223 1.00 108.53 ? 439 LEU A O     1 
ATOM   2425 C CB    . LEU A 1 465 ? 78.729  104.658 145.525 1.00 99.19  ? 439 LEU A CB    1 
ATOM   2426 C CG    . LEU A 1 465 ? 77.526  105.597 145.566 1.00 93.91  ? 439 LEU A CG    1 
ATOM   2427 C CD1   . LEU A 1 465 ? 76.748  105.482 144.247 1.00 104.92 ? 439 LEU A CD1   1 
ATOM   2428 C CD2   . LEU A 1 465 ? 76.597  105.243 146.673 1.00 102.23 ? 439 LEU A CD2   1 
ATOM   2429 N N     . CYS A 1 466 ? 79.976  106.073 148.544 1.00 119.00 ? 440 CYS A N     1 
ATOM   2430 C CA    . CYS A 1 466 ? 79.800  106.105 149.989 1.00 138.44 ? 440 CYS A CA    1 
ATOM   2431 C C     . CYS A 1 466 ? 78.599  106.979 150.337 1.00 126.74 ? 440 CYS A C     1 
ATOM   2432 O O     . CYS A 1 466 ? 78.348  108.043 149.746 1.00 108.29 ? 440 CYS A O     1 
ATOM   2433 C CB    . CYS A 1 466 ? 81.099  106.432 150.725 1.00 152.10 ? 440 CYS A CB    1 
ATOM   2434 S SG    . CYS A 1 466 ? 82.003  104.956 151.274 1.00 164.58 ? 440 CYS A SG    1 
ATOM   2435 N N     . GLN A 1 467 ? 77.813  106.479 151.284 1.00 108.49 ? 441 GLN A N     1 
ATOM   2436 C CA    . GLN A 1 467 ? 76.621  107.225 151.614 1.00 160.77 ? 441 GLN A CA    1 
ATOM   2437 C C     . GLN A 1 467 ? 76.168  106.850 153.021 1.00 196.63 ? 441 GLN A C     1 
ATOM   2438 O O     . GLN A 1 467 ? 76.805  106.024 153.681 1.00 175.86 ? 441 GLN A O     1 
ATOM   2439 C CB    . GLN A 1 467 ? 75.634  107.048 150.456 1.00 133.29 ? 441 GLN A CB    1 
ATOM   2440 C CG    . GLN A 1 467 ? 74.925  108.341 150.091 1.00 131.03 ? 441 GLN A CG    1 
ATOM   2441 C CD    . GLN A 1 467 ? 74.371  108.354 148.695 1.00 135.38 ? 441 GLN A CD    1 
ATOM   2442 O OE1   . GLN A 1 467 ? 74.713  109.222 147.882 1.00 148.06 ? 441 GLN A OE1   1 
ATOM   2443 N NE2   . GLN A 1 467 ? 73.468  107.417 148.445 1.00 131.86 ? 441 GLN A NE2   1 
ATOM   2444 N N     . PRO A 1 468 ? 75.171  107.589 153.567 1.00 201.18 ? 442 PRO A N     1 
ATOM   2445 C CA    . PRO A 1 468 ? 74.343  107.112 154.675 1.00 204.84 ? 442 PRO A CA    1 
ATOM   2446 C C     . PRO A 1 468 ? 73.721  105.737 154.439 1.00 168.36 ? 442 PRO A C     1 
ATOM   2447 O O     . PRO A 1 468 ? 72.754  105.635 153.686 1.00 146.41 ? 442 PRO A O     1 
ATOM   2448 C CB    . PRO A 1 468 ? 73.251  108.197 154.785 1.00 233.52 ? 442 PRO A CB    1 
ATOM   2449 C CG    . PRO A 1 468 ? 73.872  109.453 154.222 1.00 227.46 ? 442 PRO A CG    1 
ATOM   2450 C CD    . PRO A 1 468 ? 74.911  108.998 153.235 1.00 201.11 ? 442 PRO A CD    1 
ATOM   2451 N N     . GLY A 1 469 ? 74.301  104.701 155.072 1.00 136.24 ? 443 GLY A N     1 
ATOM   2452 C CA    . GLY A 1 469 ? 73.794  103.338 155.018 1.00 133.23 ? 443 GLY A CA    1 
ATOM   2453 C C     . GLY A 1 469 ? 74.180  102.555 153.751 1.00 156.23 ? 443 GLY A C     1 
ATOM   2454 O O     . GLY A 1 469 ? 73.846  101.377 153.632 1.00 187.60 ? 443 GLY A O     1 
ATOM   2455 N N     . LEU A 1 470 ? 74.889  103.189 152.806 1.00 156.09 ? 444 LEU A N     1 
ATOM   2456 C CA    . LEU A 1 470 ? 75.261  102.582 151.534 1.00 133.94 ? 444 LEU A CA    1 
ATOM   2457 C C     . LEU A 1 470 ? 76.763  102.700 151.394 1.00 127.78 ? 444 LEU A C     1 
ATOM   2458 O O     . LEU A 1 470 ? 77.334  103.729 151.762 1.00 116.07 ? 444 LEU A O     1 
ATOM   2459 C CB    . LEU A 1 470 ? 74.630  103.259 150.316 1.00 141.55 ? 444 LEU A CB    1 
ATOM   2460 C CG    . LEU A 1 470 ? 73.175  102.904 150.013 1.00 160.50 ? 444 LEU A CG    1 
ATOM   2461 C CD1   . LEU A 1 470 ? 72.518  103.853 149.026 1.00 152.91 ? 444 LEU A CD1   1 
ATOM   2462 C CD2   . LEU A 1 470 ? 73.156  101.492 149.498 1.00 177.20 ? 444 LEU A CD2   1 
ATOM   2463 N N     . VAL A 1 471 ? 77.351  101.679 150.769 1.00 121.09 ? 445 VAL A N     1 
ATOM   2464 C CA    . VAL A 1 471 ? 78.790  101.546 150.657 1.00 98.61  ? 445 VAL A CA    1 
ATOM   2465 C C     . VAL A 1 471 ? 79.090  100.559 149.558 1.00 128.05 ? 445 VAL A C     1 
ATOM   2466 O O     . VAL A 1 471 ? 79.343  99.380  149.820 1.00 162.60 ? 445 VAL A O     1 
ATOM   2467 C CB    . VAL A 1 471 ? 79.262  101.000 151.995 1.00 115.69 ? 445 VAL A CB    1 
ATOM   2468 C CG1   . VAL A 1 471 ? 79.689  102.134 152.911 1.00 157.61 ? 445 VAL A CG1   1 
ATOM   2469 C CG2   . VAL A 1 471 ? 78.174  100.092 152.593 1.00 112.97 ? 445 VAL A CG2   1 
ATOM   2470 N N     . ILE A 1 472 ? 78.992  101.046 148.326 1.00 129.26 ? 446 ILE A N     1 
ATOM   2471 C CA    . ILE A 1 472 ? 79.039  100.149 147.191 1.00 113.00 ? 446 ILE A CA    1 
ATOM   2472 C C     . ILE A 1 472 ? 80.428  100.254 146.582 1.00 96.63  ? 446 ILE A C     1 
ATOM   2473 O O     . ILE A 1 472 ? 80.925  101.360 146.352 1.00 87.04  ? 446 ILE A O     1 
ATOM   2474 C CB    . ILE A 1 472 ? 77.898  100.492 146.225 1.00 92.36  ? 446 ILE A CB    1 
ATOM   2475 C CG1   . ILE A 1 472 ? 76.542  100.473 146.978 1.00 102.40 ? 446 ILE A CG1   1 
ATOM   2476 C CG2   . ILE A 1 472 ? 77.958  99.536  145.048 1.00 91.28  ? 446 ILE A CG2   1 
ATOM   2477 C CD1   . ILE A 1 472 ? 75.292  100.483 146.128 1.00 96.56  ? 446 ILE A CD1   1 
ATOM   2478 N N     . ASP A 1 473 ? 81.086  99.113  146.426 1.00 67.04  ? 447 ASP A N     1 
ATOM   2479 C CA    . ASP A 1 473 ? 82.304  99.176  145.669 1.00 85.09  ? 447 ASP A CA    1 
ATOM   2480 C C     . ASP A 1 473 ? 81.987  99.018  144.182 1.00 94.60  ? 447 ASP A C     1 
ATOM   2481 O O     . ASP A 1 473 ? 81.443  97.975  143.823 1.00 108.88 ? 447 ASP A O     1 
ATOM   2482 C CB    . ASP A 1 473 ? 83.265  98.079  146.073 1.00 132.82 ? 447 ASP A CB    1 
ATOM   2483 C CG    . ASP A 1 473 ? 84.267  97.726  144.977 1.00 195.93 ? 447 ASP A CG    1 
ATOM   2484 O OD1   . ASP A 1 473 ? 83.835  97.147  143.936 1.00 146.64 ? 447 ASP A OD1   1 
ATOM   2485 O OD2   . ASP A 1 473 ? 85.463  98.074  145.141 1.00 250.04 ? 447 ASP A OD2   1 
ATOM   2486 N N     . LEU A 1 474 ? 82.442  99.960  143.316 1.00 80.14  ? 448 LEU A N     1 
ATOM   2487 C CA    . LEU A 1 474 ? 82.484  99.729  141.868 1.00 69.24  ? 448 LEU A CA    1 
ATOM   2488 C C     . LEU A 1 474 ? 83.868  99.317  141.343 1.00 76.12  ? 448 LEU A C     1 
ATOM   2489 O O     . LEU A 1 474 ? 84.818  99.154  142.106 1.00 85.42  ? 448 LEU A O     1 
ATOM   2490 C CB    . LEU A 1 474 ? 81.915  100.952 141.187 1.00 62.18  ? 448 LEU A CB    1 
ATOM   2491 C CG    . LEU A 1 474 ? 80.743  101.531 141.981 1.00 78.01  ? 448 LEU A CG    1 
ATOM   2492 C CD1   . LEU A 1 474 ? 80.213  102.839 141.445 1.00 79.89  ? 448 LEU A CD1   1 
ATOM   2493 C CD2   . LEU A 1 474 ? 79.639  100.506 141.998 1.00 76.75  ? 448 LEU A CD2   1 
ATOM   2494 N N     . GLU A 1 475 ? 83.948  99.051  140.029 1.00 76.06  ? 449 GLU A N     1 
ATOM   2495 C CA    . GLU A 1 475 ? 85.074  98.348  139.438 1.00 68.68  ? 449 GLU A CA    1 
ATOM   2496 C C     . GLU A 1 475 ? 84.850  98.075  137.970 1.00 59.80  ? 449 GLU A C     1 
ATOM   2497 O O     . GLU A 1 475 ? 83.808  97.535  137.628 1.00 102.11 ? 449 GLU A O     1 
ATOM   2498 C CB    . GLU A 1 475 ? 85.262  96.908  139.920 1.00 73.40  ? 449 GLU A CB    1 
ATOM   2499 C CG    . GLU A 1 475 ? 86.707  96.499  139.638 1.00 114.57 ? 449 GLU A CG    1 
ATOM   2500 C CD    . GLU A 1 475 ? 87.263  95.135  140.029 1.00 175.27 ? 449 GLU A CD    1 
ATOM   2501 O OE1   . GLU A 1 475 ? 86.903  94.570  141.095 1.00 182.29 ? 449 GLU A OE1   1 
ATOM   2502 O OE2   . GLU A 1 475 ? 88.158  94.684  139.264 1.00 181.38 ? 449 GLU A OE2   1 
ATOM   2503 N N     . THR A 1 476 ? 85.874  98.251  137.130 1.00 72.26  ? 450 THR A N     1 
ATOM   2504 C CA    . THR A 1 476 ? 85.823  97.749  135.752 1.00 64.02  ? 450 THR A CA    1 
ATOM   2505 C C     . THR A 1 476 ? 87.196  97.683  135.052 1.00 62.64  ? 450 THR A C     1 
ATOM   2506 O O     . THR A 1 476 ? 88.263  97.887  135.635 1.00 57.08  ? 450 THR A O     1 
ATOM   2507 C CB    . THR A 1 476 ? 84.861  98.648  134.977 1.00 66.90  ? 450 THR A CB    1 
ATOM   2508 O OG1   . THR A 1 476 ? 84.268  97.753  134.031 1.00 71.29  ? 450 THR A OG1   1 
ATOM   2509 C CG2   . THR A 1 476 ? 85.541  99.908  134.444 1.00 73.11  ? 450 THR A CG2   1 
ATOM   2510 N N     . THR A 1 477 ? 87.145  97.432  133.739 1.00 65.08  ? 451 THR A N     1 
ATOM   2511 C CA    . THR A 1 477 ? 88.288  96.984  132.974 1.00 49.07  ? 451 THR A CA    1 
ATOM   2512 C C     . THR A 1 477 ? 88.130  97.305  131.501 1.00 48.86  ? 451 THR A C     1 
ATOM   2513 O O     . THR A 1 477 ? 87.201  96.875  130.841 1.00 82.01  ? 451 THR A O     1 
ATOM   2514 C CB    . THR A 1 477 ? 88.296  95.483  133.126 1.00 54.17  ? 451 THR A CB    1 
ATOM   2515 O OG1   . THR A 1 477 ? 87.937  95.196  134.477 1.00 69.25  ? 451 THR A OG1   1 
ATOM   2516 C CG2   . THR A 1 477 ? 89.661  94.956  132.761 1.00 78.06  ? 451 THR A CG2   1 
ATOM   2517 N N     . SER A 1 478 ? 89.071  98.039  130.959 1.00 54.47  ? 452 SER A N     1 
ATOM   2518 C CA    . SER A 1 478 ? 89.241  98.151  129.521 1.00 60.90  ? 452 SER A CA    1 
ATOM   2519 C C     . SER A 1 478 ? 89.320  96.789  128.866 1.00 61.11  ? 452 SER A C     1 
ATOM   2520 O O     . SER A 1 478 ? 89.890  95.892  129.502 1.00 68.66  ? 452 SER A O     1 
ATOM   2521 C CB    . SER A 1 478 ? 90.568  98.843  129.252 1.00 63.41  ? 452 SER A CB    1 
ATOM   2522 O OG    . SER A 1 478 ? 91.299  98.229  128.202 1.00 54.25  ? 452 SER A OG    1 
ATOM   2523 N N     . LEU A 1 479 ? 89.005  96.722  127.556 1.00 40.21  ? 453 LEU A N     1 
ATOM   2524 C CA    . LEU A 1 479 ? 89.521  95.601  126.763 1.00 44.03  ? 453 LEU A CA    1 
ATOM   2525 C C     . LEU A 1 479 ? 91.042  95.431  126.842 1.00 48.86  ? 453 LEU A C     1 
ATOM   2526 O O     . LEU A 1 479 ? 91.806  96.406  126.794 1.00 47.07  ? 453 LEU A O     1 
ATOM   2527 C CB    . LEU A 1 479 ? 89.184  95.704  125.295 1.00 41.99  ? 453 LEU A CB    1 
ATOM   2528 C CG    . LEU A 1 479 ? 87.701  95.812  125.026 1.00 47.73  ? 453 LEU A CG    1 
ATOM   2529 C CD1   . LEU A 1 479 ? 87.356  96.700  123.853 1.00 50.42  ? 453 LEU A CD1   1 
ATOM   2530 C CD2   . LEU A 1 479 ? 87.381  94.362  124.826 1.00 51.07  ? 453 LEU A CD2   1 
ATOM   2531 N N     . PRO A 1 480 ? 91.540  94.191  126.723 1.00 46.06  ? 454 PRO A N     1 
ATOM   2532 C CA    . PRO A 1 480 ? 92.967  93.931  126.707 1.00 59.59  ? 454 PRO A CA    1 
ATOM   2533 C C     . PRO A 1 480 ? 93.621  94.861  125.702 1.00 49.82  ? 454 PRO A C     1 
ATOM   2534 O O     . PRO A 1 480 ? 93.099  95.010  124.589 1.00 45.04  ? 454 PRO A O     1 
ATOM   2535 C CB    . PRO A 1 480 ? 93.131  92.496  126.212 1.00 65.90  ? 454 PRO A CB    1 
ATOM   2536 C CG    . PRO A 1 480 ? 91.796  91.887  126.383 1.00 55.53  ? 454 PRO A CG    1 
ATOM   2537 C CD    . PRO A 1 480 ? 90.824  93.042  126.236 1.00 54.02  ? 454 PRO A CD    1 
ATOM   2538 N N     . VAL A 1 481 ? 94.820  95.265  126.113 1.00 42.04  ? 455 VAL A N     1 
ATOM   2539 C CA    . VAL A 1 481 ? 95.647  96.288  125.513 1.00 45.63  ? 455 VAL A CA    1 
ATOM   2540 C C     . VAL A 1 481 ? 96.964  95.658  125.095 1.00 49.83  ? 455 VAL A C     1 
ATOM   2541 O O     . VAL A 1 481 ? 97.347  94.660  125.691 1.00 61.48  ? 455 VAL A O     1 
ATOM   2542 C CB    . VAL A 1 481 ? 95.907  97.343  126.586 1.00 44.40  ? 455 VAL A CB    1 
ATOM   2543 C CG1   . VAL A 1 481 ? 97.285  97.942  126.431 1.00 46.27  ? 455 VAL A CG1   1 
ATOM   2544 C CG2   . VAL A 1 481 ? 94.800  98.401  126.606 1.00 43.90  ? 455 VAL A CG2   1 
ATOM   2545 N N     . VAL A 1 482 ? 97.649  96.227  124.095 1.00 42.55  ? 456 VAL A N     1 
ATOM   2546 C CA    . VAL A 1 482 ? 98.995  95.770  123.783 1.00 42.99  ? 456 VAL A CA    1 
ATOM   2547 C C     . VAL A 1 482 ? 100.005 96.885  123.998 1.00 55.21  ? 456 VAL A C     1 
ATOM   2548 O O     . VAL A 1 482 ? 99.661  98.031  123.718 1.00 63.86  ? 456 VAL A O     1 
ATOM   2549 C CB    . VAL A 1 482 ? 98.984  95.408  122.319 1.00 38.30  ? 456 VAL A CB    1 
ATOM   2550 C CG1   . VAL A 1 482 ? 100.407 95.401  121.775 1.00 37.72  ? 456 VAL A CG1   1 
ATOM   2551 C CG2   . VAL A 1 482 ? 98.244  94.118  122.152 1.00 39.84  ? 456 VAL A CG2   1 
ATOM   2552 N N     . VAL A 1 483 ? 101.231 96.578  124.446 1.00 54.07  ? 457 VAL A N     1 
ATOM   2553 C CA    . VAL A 1 483 ? 102.113 97.681  124.829 1.00 64.96  ? 457 VAL A CA    1 
ATOM   2554 C C     . VAL A 1 483 ? 103.422 97.671  124.050 1.00 54.45  ? 457 VAL A C     1 
ATOM   2555 O O     . VAL A 1 483 ? 104.225 96.763  124.178 1.00 70.91  ? 457 VAL A O     1 
ATOM   2556 C CB    . VAL A 1 483 ? 102.490 97.735  126.316 1.00 66.51  ? 457 VAL A CB    1 
ATOM   2557 C CG1   . VAL A 1 483 ? 103.510 98.838  126.546 1.00 53.31  ? 457 VAL A CG1   1 
ATOM   2558 C CG2   . VAL A 1 483 ? 101.294 97.927  127.211 1.00 68.85  ? 457 VAL A CG2   1 
ATOM   2559 N N     . ILE A 1 484 ? 103.738 98.738  123.352 1.00 55.76  ? 458 ILE A N     1 
ATOM   2560 C CA    . ILE A 1 484 ? 104.964 98.663  122.584 1.00 65.44  ? 458 ILE A CA    1 
ATOM   2561 C C     . ILE A 1 484 ? 105.802 99.872  122.937 1.00 75.36  ? 458 ILE A C     1 
ATOM   2562 O O     . ILE A 1 484 ? 105.365 100.745 123.693 1.00 62.61  ? 458 ILE A O     1 
ATOM   2563 C CB    . ILE A 1 484 ? 104.685 98.644  121.092 1.00 53.04  ? 458 ILE A CB    1 
ATOM   2564 C CG1   . ILE A 1 484 ? 103.933 99.921  120.747 1.00 56.87  ? 458 ILE A CG1   1 
ATOM   2565 C CG2   . ILE A 1 484 ? 103.907 97.392  120.743 1.00 50.83  ? 458 ILE A CG2   1 
ATOM   2566 C CD1   . ILE A 1 484 ? 103.505 99.961  119.297 1.00 67.90  ? 458 ILE A CD1   1 
ATOM   2567 N N     . SER A 1 485 ? 107.000 99.856  122.338 1.00 66.44  ? 459 SER A N     1 
ATOM   2568 C CA    . SER A 1 485 ? 108.097 100.738 122.685 1.00 67.14  ? 459 SER A CA    1 
ATOM   2569 C C     . SER A 1 485 ? 108.295 101.773 121.600 1.00 57.54  ? 459 SER A C     1 
ATOM   2570 O O     . SER A 1 485 ? 108.774 102.849 121.904 1.00 66.54  ? 459 SER A O     1 
ATOM   2571 C CB    . SER A 1 485 ? 109.358 99.918  122.795 1.00 90.47  ? 459 SER A CB    1 
ATOM   2572 O OG    . SER A 1 485 ? 109.626 99.203  121.584 1.00 72.58  ? 459 SER A OG    1 
ATOM   2573 N N     . ASN A 1 486 ? 107.960 101.365 120.375 1.00 54.83  ? 460 ASN A N     1 
ATOM   2574 C CA    . ASN A 1 486 ? 108.335 102.012 119.146 1.00 66.63  ? 460 ASN A CA    1 
ATOM   2575 C C     . ASN A 1 486 ? 107.281 101.727 118.077 1.00 70.47  ? 460 ASN A C     1 
ATOM   2576 O O     . ASN A 1 486 ? 106.938 100.568 117.822 1.00 62.63  ? 460 ASN A O     1 
ATOM   2577 C CB    . ASN A 1 486 ? 109.623 101.419 118.575 1.00 77.67  ? 460 ASN A CB    1 
ATOM   2578 C CG    . ASN A 1 486 ? 110.060 102.217 117.367 1.00 78.45  ? 460 ASN A CG    1 
ATOM   2579 O OD1   . ASN A 1 486 ? 109.318 102.366 116.382 1.00 75.68  ? 460 ASN A OD1   1 
ATOM   2580 N ND2   . ASN A 1 486 ? 111.215 102.835 117.472 1.00 73.26  ? 460 ASN A ND2   1 
ATOM   2581 N N     . VAL A 1 487 ? 106.866 102.765 117.351 1.00 63.75  ? 461 VAL A N     1 
ATOM   2582 C CA    . VAL A 1 487 ? 105.766 102.607 116.423 1.00 51.14  ? 461 VAL A CA    1 
ATOM   2583 C C     . VAL A 1 487 ? 106.197 101.674 115.321 1.00 49.75  ? 461 VAL A C     1 
ATOM   2584 O O     . VAL A 1 487 ? 105.331 101.292 114.540 1.00 64.93  ? 461 VAL A O     1 
ATOM   2585 C CB    . VAL A 1 487 ? 105.308 103.867 115.708 1.00 57.28  ? 461 VAL A CB    1 
ATOM   2586 C CG1   . VAL A 1 487 ? 104.761 104.981 116.634 1.00 54.95  ? 461 VAL A CG1   1 
ATOM   2587 C CG2   . VAL A 1 487 ? 106.486 104.240 114.812 1.00 66.84  ? 461 VAL A CG2   1 
ATOM   2588 N N     . SER A 1 488 ? 107.482 101.339 115.217 1.00 44.23  ? 462 SER A N     1 
ATOM   2589 C CA    . SER A 1 488 ? 107.835 100.235 114.341 1.00 57.38  ? 462 SER A CA    1 
ATOM   2590 C C     . SER A 1 488 ? 106.951 99.017  114.553 1.00 68.91  ? 462 SER A C     1 
ATOM   2591 O O     . SER A 1 488 ? 106.789 98.224  113.628 1.00 68.53  ? 462 SER A O     1 
ATOM   2592 C CB    . SER A 1 488 ? 109.217 99.744  114.569 1.00 89.29  ? 462 SER A CB    1 
ATOM   2593 O OG    . SER A 1 488 ? 109.319 98.347  114.270 1.00 88.18  ? 462 SER A OG    1 
ATOM   2594 N N     . GLN A 1 489 ? 106.537 98.786  115.809 1.00 70.00  ? 463 GLN A N     1 
ATOM   2595 C CA    . GLN A 1 489 ? 105.874 97.547  116.192 1.00 65.30  ? 463 GLN A CA    1 
ATOM   2596 C C     . GLN A 1 489 ? 104.375 97.631  115.846 1.00 59.02  ? 463 GLN A C     1 
ATOM   2597 O O     . GLN A 1 489 ? 103.725 96.662  115.459 1.00 55.42  ? 463 GLN A O     1 
ATOM   2598 C CB    . GLN A 1 489 ? 106.199 97.325  117.664 1.00 57.85  ? 463 GLN A CB    1 
ATOM   2599 C CG    . GLN A 1 489 ? 107.676 97.469  118.034 1.00 67.47  ? 463 GLN A CG    1 
ATOM   2600 C CD    . GLN A 1 489 ? 107.988 97.223  119.516 1.00 71.44  ? 463 GLN A CD    1 
ATOM   2601 O OE1   . GLN A 1 489 ? 107.682 98.030  120.444 1.00 35.16  ? 463 GLN A OE1   1 
ATOM   2602 N NE2   . GLN A 1 489 ? 108.593 96.031  119.711 1.00 60.24  ? 463 GLN A NE2   1 
ATOM   2603 N N     . LEU A 1 490 ? 103.852 98.838  115.872 1.00 55.63  ? 464 LEU A N     1 
ATOM   2604 C CA    . LEU A 1 490 ? 102.435 99.051  115.792 1.00 50.13  ? 464 LEU A CA    1 
ATOM   2605 C C     . LEU A 1 490 ? 101.781 98.119  114.797 1.00 48.21  ? 464 LEU A C     1 
ATOM   2606 O O     . LEU A 1 490 ? 100.860 97.443  115.197 1.00 65.77  ? 464 LEU A O     1 
ATOM   2607 C CB    . LEU A 1 490 ? 102.210 100.509 115.443 1.00 49.16  ? 464 LEU A CB    1 
ATOM   2608 C CG    . LEU A 1 490 ? 100.836 100.972 115.901 1.00 53.03  ? 464 LEU A CG    1 
ATOM   2609 C CD1   . LEU A 1 490 ? 100.775 102.482 116.003 1.00 58.25  ? 464 LEU A CD1   1 
ATOM   2610 C CD2   . LEU A 1 490 ? 99.942  100.463 114.852 1.00 93.91  ? 464 LEU A CD2   1 
ATOM   2611 N N     . PRO A 1 491 ? 102.170 98.036  113.513 1.00 52.45  ? 465 PRO A N     1 
ATOM   2612 C CA    . PRO A 1 491 ? 101.661 97.017  112.576 1.00 61.31  ? 465 PRO A CA    1 
ATOM   2613 C C     . PRO A 1 491 ? 101.407 95.626  113.145 1.00 63.87  ? 465 PRO A C     1 
ATOM   2614 O O     . PRO A 1 491 ? 100.256 95.205  113.334 1.00 66.54  ? 465 PRO A O     1 
ATOM   2615 C CB    . PRO A 1 491 ? 102.732 96.872  111.538 1.00 49.24  ? 465 PRO A CB    1 
ATOM   2616 C CG    . PRO A 1 491 ? 103.783 97.767  112.061 1.00 66.87  ? 465 PRO A CG    1 
ATOM   2617 C CD    . PRO A 1 491 ? 103.157 98.887  112.889 1.00 54.69  ? 465 PRO A CD    1 
ATOM   2618 N N     . SER A 1 492 ? 102.475 94.916  113.478 1.00 54.89  ? 466 SER A N     1 
ATOM   2619 C CA    . SER A 1 492 ? 102.228 93.654  114.135 1.00 60.01  ? 466 SER A CA    1 
ATOM   2620 C C     . SER A 1 492 ? 101.303 93.783  115.374 1.00 56.38  ? 466 SER A C     1 
ATOM   2621 O O     . SER A 1 492 ? 100.457 92.937  115.681 1.00 52.38  ? 466 SER A O     1 
ATOM   2622 C CB    . SER A 1 492 ? 103.483 93.028  114.451 1.00 62.51  ? 466 SER A CB    1 
ATOM   2623 O OG    . SER A 1 492 ? 103.191 91.658  114.657 1.00 91.81  ? 466 SER A OG    1 
ATOM   2624 N N     . GLY A 1 493 ? 101.364 94.907  116.062 1.00 47.64  ? 467 GLY A N     1 
ATOM   2625 C CA    . GLY A 1 493 ? 100.536 95.130  117.238 1.00 41.39  ? 467 GLY A CA    1 
ATOM   2626 C C     . GLY A 1 493 ? 99.044  95.131  116.962 1.00 43.89  ? 467 GLY A C     1 
ATOM   2627 O O     . GLY A 1 493 ? 98.183  94.879  117.816 1.00 50.02  ? 467 GLY A O     1 
ATOM   2628 N N     . TRP A 1 494 ? 98.705  95.474  115.751 1.00 50.52  ? 468 TRP A N     1 
ATOM   2629 C CA    . TRP A 1 494 ? 97.309  95.740  115.514 1.00 47.38  ? 468 TRP A CA    1 
ATOM   2630 C C     . TRP A 1 494 ? 96.807  94.406  115.053 1.00 49.31  ? 468 TRP A C     1 
ATOM   2631 O O     . TRP A 1 494 ? 95.726  93.995  115.423 1.00 52.87  ? 468 TRP A O     1 
ATOM   2632 C CB    . TRP A 1 494 ? 97.224  96.887  114.515 1.00 41.90  ? 468 TRP A CB    1 
ATOM   2633 C CG    . TRP A 1 494 ? 95.868  97.163  114.026 1.00 38.35  ? 468 TRP A CG    1 
ATOM   2634 C CD1   . TRP A 1 494 ? 95.289  96.943  112.811 1.00 42.28  ? 468 TRP A CD1   1 
ATOM   2635 C CD2   . TRP A 1 494 ? 94.898  97.723  114.857 1.00 50.19  ? 468 TRP A CD2   1 
ATOM   2636 N NE1   . TRP A 1 494 ? 93.996  97.351  112.817 1.00 43.32  ? 468 TRP A NE1   1 
ATOM   2637 C CE2   . TRP A 1 494 ? 93.732  97.814  114.079 1.00 55.69  ? 468 TRP A CE2   1 
ATOM   2638 C CE3   . TRP A 1 494 ? 94.920  98.135  116.176 1.00 65.90  ? 468 TRP A CE3   1 
ATOM   2639 C CZ2   . TRP A 1 494 ? 92.573  98.332  114.615 1.00 60.36  ? 468 TRP A CZ2   1 
ATOM   2640 C CZ3   . TRP A 1 494 ? 93.768  98.664  116.702 1.00 69.46  ? 468 TRP A CZ3   1 
ATOM   2641 C CH2   . TRP A 1 494 ? 92.629  98.776  115.911 1.00 62.39  ? 468 TRP A CH2   1 
ATOM   2642 N N     . ALA A 1 495 ? 97.722  93.682  114.416 1.00 45.05  ? 469 ALA A N     1 
ATOM   2643 C CA    . ALA A 1 495 ? 97.436  92.298  114.147 1.00 51.11  ? 469 ALA A CA    1 
ATOM   2644 C C     . ALA A 1 495 ? 96.951  91.546  115.375 1.00 52.83  ? 469 ALA A C     1 
ATOM   2645 O O     . ALA A 1 495 ? 96.011  90.782  115.288 1.00 58.42  ? 469 ALA A O     1 
ATOM   2646 C CB    . ALA A 1 495 ? 98.652  91.665  113.658 1.00 55.58  ? 469 ALA A CB    1 
ATOM   2647 N N     . SER A 1 496 ? 97.569  91.742  116.524 1.00 51.00  ? 470 SER A N     1 
ATOM   2648 C CA    . SER A 1 496 ? 97.018  91.059  117.672 1.00 53.64  ? 470 SER A CA    1 
ATOM   2649 C C     . SER A 1 496 ? 95.655  91.609  118.069 1.00 47.50  ? 470 SER A C     1 
ATOM   2650 O O     . SER A 1 496 ? 94.781  90.779  118.269 1.00 42.14  ? 470 SER A O     1 
ATOM   2651 C CB    . SER A 1 496 ? 97.878  91.105  118.857 1.00 67.45  ? 470 SER A CB    1 
ATOM   2652 O OG    . SER A 1 496 ? 99.238  90.909  118.518 1.00 89.42  ? 470 SER A OG    1 
ATOM   2653 N N     . ILE A 1 497 ? 95.460  92.935  118.241 1.00 36.70  ? 471 ILE A N     1 
ATOM   2654 C CA    . ILE A 1 497 ? 94.090  93.406  118.529 1.00 40.49  ? 471 ILE A CA    1 
ATOM   2655 C C     . ILE A 1 497 ? 92.996  92.976  117.515 1.00 37.77  ? 471 ILE A C     1 
ATOM   2656 O O     . ILE A 1 497 ? 91.840  92.894  117.867 1.00 33.19  ? 471 ILE A O     1 
ATOM   2657 C CB    . ILE A 1 497 ? 94.063  94.931  118.653 1.00 40.23  ? 471 ILE A CB    1 
ATOM   2658 C CG1   . ILE A 1 497 ? 94.861  95.410  119.804 1.00 40.85  ? 471 ILE A CG1   1 
ATOM   2659 C CG2   . ILE A 1 497 ? 92.657  95.497  118.682 1.00 34.46  ? 471 ILE A CG2   1 
ATOM   2660 C CD1   . ILE A 1 497 ? 94.906  94.474  120.950 1.00 46.04  ? 471 ILE A CD1   1 
ATOM   2661 N N     . LEU A 1 498 ? 93.323  92.693  116.259 1.00 41.49  ? 472 LEU A N     1 
ATOM   2662 C CA    . LEU A 1 498 ? 92.297  92.281  115.330 1.00 47.83  ? 472 LEU A CA    1 
ATOM   2663 C C     . LEU A 1 498 ? 91.821  90.905  115.751 1.00 50.40  ? 472 LEU A C     1 
ATOM   2664 O O     . LEU A 1 498 ? 90.631  90.706  115.978 1.00 60.84  ? 472 LEU A O     1 
ATOM   2665 C CB    . LEU A 1 498 ? 92.756  92.257  113.868 1.00 52.15  ? 472 LEU A CB    1 
ATOM   2666 C CG    . LEU A 1 498 ? 92.977  93.638  113.221 1.00 60.73  ? 472 LEU A CG    1 
ATOM   2667 C CD1   . LEU A 1 498 ? 93.555  93.508  111.795 1.00 50.17  ? 472 LEU A CD1   1 
ATOM   2668 C CD2   . LEU A 1 498 ? 91.730  94.584  113.272 1.00 62.29  ? 472 LEU A CD2   1 
ATOM   2669 N N     . TRP A 1 499 ? 92.777  89.993  115.857 1.00 45.95  ? 473 TRP A N     1 
ATOM   2670 C CA    . TRP A 1 499 ? 92.481  88.588  116.045 1.00 47.94  ? 473 TRP A CA    1 
ATOM   2671 C C     . TRP A 1 499 ? 91.692  88.371  117.323 1.00 57.98  ? 473 TRP A C     1 
ATOM   2672 O O     . TRP A 1 499 ? 90.958  87.403  117.430 1.00 85.16  ? 473 TRP A O     1 
ATOM   2673 C CB    . TRP A 1 499 ? 93.778  87.808  116.181 1.00 43.12  ? 473 TRP A CB    1 
ATOM   2674 C CG    . TRP A 1 499 ? 93.718  86.414  115.632 1.00 56.92  ? 473 TRP A CG    1 
ATOM   2675 C CD1   . TRP A 1 499 ? 93.725  85.266  116.350 1.00 65.45  ? 473 TRP A CD1   1 
ATOM   2676 C CD2   . TRP A 1 499 ? 93.756  86.002  114.263 1.00 61.02  ? 473 TRP A CD2   1 
ATOM   2677 N NE1   . TRP A 1 499 ? 93.754  84.184  115.532 1.00 51.73  ? 473 TRP A NE1   1 
ATOM   2678 C CE2   . TRP A 1 499 ? 93.775  84.608  114.249 1.00 49.92  ? 473 TRP A CE2   1 
ATOM   2679 C CE3   . TRP A 1 499 ? 93.787  86.678  113.058 1.00 80.74  ? 473 TRP A CE3   1 
ATOM   2680 C CZ2   . TRP A 1 499 ? 93.790  83.866  113.089 1.00 63.22  ? 473 TRP A CZ2   1 
ATOM   2681 C CZ3   . TRP A 1 499 ? 93.780  85.941  111.900 1.00 100.75 ? 473 TRP A CZ3   1 
ATOM   2682 C CH2   . TRP A 1 499 ? 93.790  84.548  111.917 1.00 80.60  ? 473 TRP A CH2   1 
ATOM   2683 N N     . TYR A 1 500 ? 91.878  89.225  118.316 1.00 52.64  ? 474 TYR A N     1 
ATOM   2684 C CA    . TYR A 1 500 ? 91.208  88.991  119.571 1.00 58.91  ? 474 TYR A CA    1 
ATOM   2685 C C     . TYR A 1 500 ? 89.823  89.647  119.498 1.00 53.74  ? 474 TYR A C     1 
ATOM   2686 O O     . TYR A 1 500 ? 88.793  88.991  119.646 1.00 49.75  ? 474 TYR A O     1 
ATOM   2687 C CB    . TYR A 1 500 ? 92.178  89.432  120.660 1.00 62.14  ? 474 TYR A CB    1 
ATOM   2688 C CG    . TYR A 1 500 ? 91.603  89.312  122.051 1.00 67.21  ? 474 TYR A CG    1 
ATOM   2689 C CD1   . TYR A 1 500 ? 90.608  90.176  122.474 1.00 71.30  ? 474 TYR A CD1   1 
ATOM   2690 C CD2   . TYR A 1 500 ? 92.053  88.331  122.920 1.00 77.40  ? 474 TYR A CD2   1 
ATOM   2691 C CE1   . TYR A 1 500 ? 90.058  90.061  123.741 1.00 71.73  ? 474 TYR A CE1   1 
ATOM   2692 C CE2   . TYR A 1 500 ? 91.529  88.231  124.194 1.00 82.15  ? 474 TYR A CE2   1 
ATOM   2693 C CZ    . TYR A 1 500 ? 90.538  89.109  124.599 1.00 60.06  ? 474 TYR A CZ    1 
ATOM   2694 O OH    . TYR A 1 500 ? 89.933  89.096  125.794 1.00 76.03  ? 474 TYR A OH    1 
ATOM   2695 N N     . ASN A 1 501 ? 89.738  90.913  119.173 1.00 42.44  ? 475 ASN A N     1 
ATOM   2696 C CA    . ASN A 1 501 ? 88.399  91.430  119.058 1.00 41.47  ? 475 ASN A CA    1 
ATOM   2697 C C     . ASN A 1 501 ? 87.607  90.811  117.924 1.00 40.91  ? 475 ASN A C     1 
ATOM   2698 O O     . ASN A 1 501 ? 86.584  91.336  117.502 1.00 62.03  ? 475 ASN A O     1 
ATOM   2699 C CB    . ASN A 1 501 ? 88.400  92.919  118.813 1.00 50.74  ? 475 ASN A CB    1 
ATOM   2700 C CG    . ASN A 1 501 ? 88.857  93.584  120.059 1.00 54.34  ? 475 ASN A CG    1 
ATOM   2701 O OD1   . ASN A 1 501 ? 90.059  93.825  120.230 1.00 53.65  ? 475 ASN A OD1   1 
ATOM   2702 N ND2   . ASN A 1 501 ? 87.934  93.593  121.001 1.00 65.90  ? 475 ASN A ND2   1 
ATOM   2703 N N     . MET A 1 502 ? 88.036  89.694  117.407 1.00 54.70  ? 476 MET A N     1 
ATOM   2704 C CA    . MET A 1 502 ? 87.260  89.112  116.337 1.00 61.75  ? 476 MET A CA    1 
ATOM   2705 C C     . MET A 1 502 ? 86.900  87.686  116.761 1.00 52.29  ? 476 MET A C     1 
ATOM   2706 O O     . MET A 1 502 ? 85.740  87.301  116.644 1.00 68.07  ? 476 MET A O     1 
ATOM   2707 C CB    . MET A 1 502 ? 88.036  89.255  115.027 1.00 61.17  ? 476 MET A CB    1 
ATOM   2708 C CG    . MET A 1 502 ? 87.834  88.053  114.213 1.00 68.22  ? 476 MET A CG    1 
ATOM   2709 S SD    . MET A 1 502 ? 88.388  88.166  112.514 1.00 69.02  ? 476 MET A SD    1 
ATOM   2710 C CE    . MET A 1 502 ? 89.924  87.211  112.650 1.00 81.99  ? 476 MET A CE    1 
ATOM   2711 N N     . LEU A 1 503 ? 87.806  86.975  117.423 1.00 39.96  ? 477 LEU A N     1 
ATOM   2712 C CA    . LEU A 1 503 ? 87.422  85.686  117.952 1.00 57.10  ? 477 LEU A CA    1 
ATOM   2713 C C     . LEU A 1 503 ? 87.138  85.608  119.458 1.00 88.11  ? 477 LEU A C     1 
ATOM   2714 O O     . LEU A 1 503 ? 87.309  84.541  120.049 1.00 114.19 ? 477 LEU A O     1 
ATOM   2715 C CB    . LEU A 1 503 ? 88.585  84.785  117.575 1.00 50.64  ? 477 LEU A CB    1 
ATOM   2716 C CG    . LEU A 1 503 ? 89.031  84.981  116.136 1.00 53.79  ? 477 LEU A CG    1 
ATOM   2717 C CD1   . LEU A 1 503 ? 90.117  83.962  115.749 1.00 65.72  ? 477 LEU A CD1   1 
ATOM   2718 C CD2   . LEU A 1 503 ? 87.833  84.877  115.248 1.00 49.08  ? 477 LEU A CD2   1 
ATOM   2719 N N     . VAL A 1 504 ? 86.639  86.660  120.101 1.00 96.60  ? 478 VAL A N     1 
ATOM   2720 C CA    . VAL A 1 504 ? 86.447  86.583  121.542 1.00 82.02  ? 478 VAL A CA    1 
ATOM   2721 C C     . VAL A 1 504 ? 85.403  87.582  122.003 1.00 120.78 ? 478 VAL A C     1 
ATOM   2722 O O     . VAL A 1 504 ? 85.465  88.760  121.656 1.00 134.89 ? 478 VAL A O     1 
ATOM   2723 C CB    . VAL A 1 504 ? 87.763  86.824  122.269 1.00 75.41  ? 478 VAL A CB    1 
ATOM   2724 C CG1   . VAL A 1 504 ? 87.588  87.604  123.548 1.00 82.41  ? 478 VAL A CG1   1 
ATOM   2725 C CG2   . VAL A 1 504 ? 88.420  85.504  122.565 1.00 94.37  ? 478 VAL A CG2   1 
ATOM   2726 N N     . ALA A 1 505 ? 84.495  87.086  122.852 1.00 148.10 ? 479 ALA A N     1 
ATOM   2727 C CA    . ALA A 1 505 ? 83.256  87.772  123.172 1.00 129.05 ? 479 ALA A CA    1 
ATOM   2728 C C     . ALA A 1 505 ? 83.470  88.810  124.275 1.00 111.62 ? 479 ALA A C     1 
ATOM   2729 O O     . ALA A 1 505 ? 82.816  89.849  124.250 1.00 126.19 ? 479 ALA A O     1 
ATOM   2730 C CB    . ALA A 1 505 ? 82.224  86.737  123.541 1.00 175.58 ? 479 ALA A CB    1 
ATOM   2731 N N     . GLU A 1 506 ? 84.383  88.523  125.220 1.00 122.45 ? 480 GLU A N     1 
ATOM   2732 C CA    . GLU A 1 506 ? 84.885  89.468  126.218 1.00 155.57 ? 480 GLU A CA    1 
ATOM   2733 C C     . GLU A 1 506 ? 85.711  88.739  127.279 1.00 185.37 ? 480 GLU A C     1 
ATOM   2734 O O     . GLU A 1 506 ? 86.724  89.290  127.715 1.00 175.24 ? 480 GLU A O     1 
ATOM   2735 C CB    . GLU A 1 506 ? 83.906  90.316  127.037 1.00 215.45 ? 480 GLU A CB    1 
ATOM   2736 C CG    . GLU A 1 506 ? 84.519  90.939  128.303 1.00 222.36 ? 480 GLU A CG    1 
ATOM   2737 C CD    . GLU A 1 506 ? 85.909  91.608  128.240 1.00 192.20 ? 480 GLU A CD    1 
ATOM   2738 O OE1   . GLU A 1 506 ? 85.958  92.574  127.455 1.00 241.13 ? 480 GLU A OE1   1 
ATOM   2739 O OE2   . GLU A 1 506 ? 86.933  91.256  128.910 1.00 85.78  ? 480 GLU A OE2   1 
ATOM   2740 N N     . PRO A 1 507 ? 85.307  87.533  127.773 1.00 187.93 ? 481 PRO A N     1 
ATOM   2741 C CA    . PRO A 1 507 ? 86.140  86.779  128.724 1.00 186.45 ? 481 PRO A CA    1 
ATOM   2742 C C     . PRO A 1 507 ? 87.649  87.046  128.627 1.00 133.97 ? 481 PRO A C     1 
ATOM   2743 O O     . PRO A 1 507 ? 88.362  86.342  127.906 1.00 94.35  ? 481 PRO A O     1 
ATOM   2744 C CB    . PRO A 1 507 ? 85.743  85.320  128.374 1.00 186.43 ? 481 PRO A CB    1 
ATOM   2745 C CG    . PRO A 1 507 ? 84.258  85.421  128.032 1.00 178.53 ? 481 PRO A CG    1 
ATOM   2746 C CD    . PRO A 1 507 ? 84.029  86.839  127.491 1.00 156.45 ? 481 PRO A CD    1 
ATOM   2747 N N     . ARG A 1 508 ? 88.084  88.084  129.372 1.00 115.35 ? 482 ARG A N     1 
ATOM   2748 C CA    . ARG A 1 508 ? 89.398  88.714  129.294 1.00 104.34 ? 482 ARG A CA    1 
ATOM   2749 C C     . ARG A 1 508 ? 90.548  87.721  129.233 1.00 96.95  ? 482 ARG A C     1 
ATOM   2750 O O     . ARG A 1 508 ? 91.241  87.491  130.221 1.00 136.25 ? 482 ARG A O     1 
ATOM   2751 C CB    . ARG A 1 508 ? 89.690  89.460  130.589 1.00 98.79  ? 482 ARG A CB    1 
ATOM   2752 C CG    . ARG A 1 508 ? 89.356  90.921  130.466 1.00 110.18 ? 482 ARG A CG    1 
ATOM   2753 C CD    . ARG A 1 508 ? 89.681  91.434  131.848 1.00 139.35 ? 482 ARG A CD    1 
ATOM   2754 N NE    . ARG A 1 508 ? 90.991  91.115  132.431 1.00 143.56 ? 482 ARG A NE    1 
ATOM   2755 C CZ    . ARG A 1 508 ? 91.268  91.205  133.735 1.00 170.74 ? 482 ARG A CZ    1 
ATOM   2756 N NH1   . ARG A 1 508 ? 90.311  91.471  134.613 1.00 181.51 ? 482 ARG A NH1   1 
ATOM   2757 N NH2   . ARG A 1 508 ? 92.501  91.013  134.171 1.00 159.79 ? 482 ARG A NH2   1 
ATOM   2758 N N     . ASN A 1 509 ? 90.759  87.121  128.077 1.00 80.97  ? 483 ASN A N     1 
ATOM   2759 C CA    . ASN A 1 509 ? 91.509  85.897  128.097 1.00 74.07  ? 483 ASN A CA    1 
ATOM   2760 C C     . ASN A 1 509 ? 92.960  86.250  127.855 1.00 75.88  ? 483 ASN A C     1 
ATOM   2761 O O     . ASN A 1 509 ? 93.528  85.788  126.865 1.00 89.90  ? 483 ASN A O     1 
ATOM   2762 C CB    . ASN A 1 509 ? 90.952  84.863  127.133 1.00 68.47  ? 483 ASN A CB    1 
ATOM   2763 C CG    . ASN A 1 509 ? 91.745  83.594  127.317 1.00 129.75 ? 483 ASN A CG    1 
ATOM   2764 O OD1   . ASN A 1 509 ? 92.607  83.520  128.213 1.00 100.22 ? 483 ASN A OD1   1 
ATOM   2765 N ND2   . ASN A 1 509 ? 91.478  82.598  126.482 1.00 188.04 ? 483 ASN A ND2   1 
ATOM   2766 N N     . LEU A 1 510 ? 93.583  86.987  128.782 1.00 59.82  ? 484 LEU A N     1 
ATOM   2767 C CA    . LEU A 1 510 ? 94.937  87.480  128.527 1.00 62.85  ? 484 LEU A CA    1 
ATOM   2768 C C     . LEU A 1 510 ? 95.933  86.374  128.140 1.00 81.34  ? 484 LEU A C     1 
ATOM   2769 O O     . LEU A 1 510 ? 97.051  86.660  127.690 1.00 99.17  ? 484 LEU A O     1 
ATOM   2770 C CB    . LEU A 1 510 ? 95.508  88.296  129.665 1.00 57.37  ? 484 LEU A CB    1 
ATOM   2771 C CG    . LEU A 1 510 ? 94.528  89.311  130.234 1.00 73.10  ? 484 LEU A CG    1 
ATOM   2772 C CD1   . LEU A 1 510 ? 95.227  90.480  130.903 1.00 79.59  ? 484 LEU A CD1   1 
ATOM   2773 C CD2   . LEU A 1 510 ? 93.652  89.780  129.097 1.00 95.04  ? 484 LEU A CD2   1 
ATOM   2774 N N     . SER A 1 511 ? 95.536  85.116  128.257 1.00 73.36  ? 485 SER A N     1 
ATOM   2775 C CA    . SER A 1 511 ? 96.400  84.061  127.806 1.00 81.52  ? 485 SER A CA    1 
ATOM   2776 C C     . SER A 1 511 ? 95.884  83.574  126.479 1.00 90.91  ? 485 SER A C     1 
ATOM   2777 O O     . SER A 1 511 ? 95.818  82.370  126.262 1.00 151.89 ? 485 SER A O     1 
ATOM   2778 C CB    . SER A 1 511 ? 96.401  82.967  128.806 1.00 102.99 ? 485 SER A CB    1 
ATOM   2779 O OG    . SER A 1 511 ? 96.700  83.517  130.079 1.00 121.28 ? 485 SER A OG    1 
ATOM   2780 N N     . PHE A 1 512 ? 95.469  84.483  125.611 1.00 82.53  ? 486 PHE A N     1 
ATOM   2781 C CA    . PHE A 1 512 ? 94.776  84.011  124.422 1.00 84.36  ? 486 PHE A CA    1 
ATOM   2782 C C     . PHE A 1 512 ? 95.783  83.539  123.379 1.00 80.03  ? 486 PHE A C     1 
ATOM   2783 O O     . PHE A 1 512 ? 95.459  82.622  122.630 1.00 82.92  ? 486 PHE A O     1 
ATOM   2784 C CB    . PHE A 1 512 ? 93.879  85.095  123.848 1.00 61.16  ? 486 PHE A CB    1 
ATOM   2785 C CG    . PHE A 1 512 ? 93.475  84.944  122.396 1.00 57.77  ? 486 PHE A CG    1 
ATOM   2786 C CD1   . PHE A 1 512 ? 94.267  85.415  121.353 1.00 72.15  ? 486 PHE A CD1   1 
ATOM   2787 C CD2   . PHE A 1 512 ? 92.232  84.468  122.095 1.00 59.51  ? 486 PHE A CD2   1 
ATOM   2788 C CE1   . PHE A 1 512 ? 93.780  85.436  120.065 1.00 77.40  ? 486 PHE A CE1   1 
ATOM   2789 C CE2   . PHE A 1 512 ? 91.728  84.543  120.819 1.00 57.56  ? 486 PHE A CE2   1 
ATOM   2790 C CZ    . PHE A 1 512 ? 92.500  85.008  119.814 1.00 70.60  ? 486 PHE A CZ    1 
ATOM   2791 N N     . PHE A 1 513 ? 96.988  84.141  123.355 1.00 58.01  ? 487 PHE A N     1 
ATOM   2792 C CA    . PHE A 1 513 ? 97.823  83.963  122.186 1.00 61.65  ? 487 PHE A CA    1 
ATOM   2793 C C     . PHE A 1 513 ? 98.699  82.756  122.372 1.00 74.79  ? 487 PHE A C     1 
ATOM   2794 O O     . PHE A 1 513 ? 99.461  82.419  121.480 1.00 81.80  ? 487 PHE A O     1 
ATOM   2795 C CB    . PHE A 1 513 ? 98.744  85.113  121.793 1.00 74.56  ? 487 PHE A CB    1 
ATOM   2796 C CG    . PHE A 1 513 ? 97.992  86.006  120.823 1.00 60.00  ? 487 PHE A CG    1 
ATOM   2797 C CD1   . PHE A 1 513 ? 97.749  85.623  119.531 1.00 74.33  ? 487 PHE A CD1   1 
ATOM   2798 C CD2   . PHE A 1 513 ? 97.517  87.196  121.230 1.00 43.51  ? 487 PHE A CD2   1 
ATOM   2799 C CE1   . PHE A 1 513 ? 97.013  86.416  118.715 1.00 62.06  ? 487 PHE A CE1   1 
ATOM   2800 C CE2   . PHE A 1 513 ? 96.724  87.936  120.441 1.00 54.27  ? 487 PHE A CE2   1 
ATOM   2801 C CZ    . PHE A 1 513 ? 96.479  87.552  119.182 1.00 71.09  ? 487 PHE A CZ    1 
ATOM   2802 N N     . LEU A 1 514 ? 98.574  82.143  123.542 1.00 92.74  ? 488 LEU A N     1 
ATOM   2803 C CA    . LEU A 1 514 ? 99.234  80.892  123.823 1.00 93.69  ? 488 LEU A CA    1 
ATOM   2804 C C     . LEU A 1 514 ? 98.670  79.782  122.960 1.00 100.36 ? 488 LEU A C     1 
ATOM   2805 O O     . LEU A 1 514 ? 99.430  78.881  122.620 1.00 108.77 ? 488 LEU A O     1 
ATOM   2806 C CB    . LEU A 1 514 ? 99.027  80.657  125.310 1.00 97.89  ? 488 LEU A CB    1 
ATOM   2807 C CG    . LEU A 1 514 ? 100.008 81.463  126.163 1.00 107.59 ? 488 LEU A CG    1 
ATOM   2808 C CD1   . LEU A 1 514 ? 99.593  81.807  127.617 1.00 99.87  ? 488 LEU A CD1   1 
ATOM   2809 C CD2   . LEU A 1 514 ? 101.294 80.637  126.066 1.00 98.37  ? 488 LEU A CD2   1 
ATOM   2810 N N     . THR A 1 515 ? 97.379  79.861  122.589 1.00 102.55 ? 489 THR A N     1 
ATOM   2811 C CA    . THR A 1 515 ? 96.789  78.768  121.824 1.00 149.78 ? 489 THR A CA    1 
ATOM   2812 C C     . THR A 1 515 ? 95.908  79.236  120.657 1.00 125.95 ? 489 THR A C     1 
ATOM   2813 O O     . THR A 1 515 ? 94.875  78.641  120.345 1.00 119.89 ? 489 THR A O     1 
ATOM   2814 C CB    . THR A 1 515 ? 96.017  77.879  122.796 1.00 171.63 ? 489 THR A CB    1 
ATOM   2815 O OG1   . THR A 1 515 ? 96.796  77.914  123.990 1.00 133.50 ? 489 THR A OG1   1 
ATOM   2816 C CG2   . THR A 1 515 ? 95.795  76.492  122.210 1.00 192.27 ? 489 THR A CG2   1 
ATOM   2817 N N     . PRO A 1 516 ? 96.386  80.190  119.843 1.00 94.24  ? 490 PRO A N     1 
ATOM   2818 C CA    . PRO A 1 516 ? 95.508  81.145  119.179 1.00 78.12  ? 490 PRO A CA    1 
ATOM   2819 C C     . PRO A 1 516 ? 94.732  80.394  118.132 1.00 67.51  ? 490 PRO A C     1 
ATOM   2820 O O     . PRO A 1 516 ? 95.325  79.672  117.336 1.00 82.17  ? 490 PRO A O     1 
ATOM   2821 C CB    . PRO A 1 516 ? 96.413  82.194  118.608 1.00 86.31  ? 490 PRO A CB    1 
ATOM   2822 C CG    . PRO A 1 516 ? 97.724  81.450  118.405 1.00 113.14 ? 490 PRO A CG    1 
ATOM   2823 C CD    . PRO A 1 516 ? 97.781  80.317  119.430 1.00 112.15 ? 490 PRO A CD    1 
ATOM   2824 N N     . PRO A 1 517 ? 93.397  80.531  118.153 1.00 60.91  ? 491 PRO A N     1 
ATOM   2825 C CA    . PRO A 1 517 ? 92.508  79.657  117.393 1.00 65.64  ? 491 PRO A CA    1 
ATOM   2826 C C     . PRO A 1 517 ? 92.498  80.154  115.971 1.00 70.68  ? 491 PRO A C     1 
ATOM   2827 O O     . PRO A 1 517 ? 92.988  81.240  115.758 1.00 77.44  ? 491 PRO A O     1 
ATOM   2828 C CB    . PRO A 1 517 ? 91.231  79.938  118.061 1.00 81.13  ? 491 PRO A CB    1 
ATOM   2829 C CG    . PRO A 1 517 ? 91.312  81.406  118.327 1.00 72.84  ? 491 PRO A CG    1 
ATOM   2830 C CD    . PRO A 1 517 ? 92.684  81.564  118.892 1.00 54.43  ? 491 PRO A CD    1 
ATOM   2831 N N     . CYS A 1 518 ? 91.891  79.389  115.057 1.00 97.36  ? 492 CYS A N     1 
ATOM   2832 C CA    . CYS A 1 518 ? 91.789  79.755  113.648 1.00 93.37  ? 492 CYS A CA    1 
ATOM   2833 C C     . CYS A 1 518 ? 90.488  80.491  113.344 1.00 83.51  ? 492 CYS A C     1 
ATOM   2834 O O     . CYS A 1 518 ? 89.490  80.365  114.058 1.00 71.70  ? 492 CYS A O     1 
ATOM   2835 C CB    . CYS A 1 518 ? 91.854  78.529  112.766 1.00 94.21  ? 492 CYS A CB    1 
ATOM   2836 S SG    . CYS A 1 518 ? 93.391  77.619  113.050 1.00 154.31 ? 492 CYS A SG    1 
ATOM   2837 N N     . ALA A 1 519 ? 90.539  81.308  112.290 1.00 82.84  ? 493 ALA A N     1 
ATOM   2838 C CA    . ALA A 1 519 ? 89.427  82.183  111.957 1.00 78.60  ? 493 ALA A CA    1 
ATOM   2839 C C     . ALA A 1 519 ? 88.868  81.683  110.642 1.00 69.64  ? 493 ALA A C     1 
ATOM   2840 O O     . ALA A 1 519 ? 89.558  80.956  109.930 1.00 105.57 ? 493 ALA A O     1 
ATOM   2841 C CB    . ALA A 1 519 ? 89.901  83.605  111.905 1.00 77.01  ? 493 ALA A CB    1 
ATOM   2842 N N     . ARG A 1 520 ? 87.609  81.948  110.374 1.00 55.43  ? 494 ARG A N     1 
ATOM   2843 C CA    . ARG A 1 520 ? 87.059  81.338  109.189 1.00 62.52  ? 494 ARG A CA    1 
ATOM   2844 C C     . ARG A 1 520 ? 87.161  82.392  108.098 1.00 61.56  ? 494 ARG A C     1 
ATOM   2845 O O     . ARG A 1 520 ? 87.120  83.580  108.402 1.00 67.00  ? 494 ARG A O     1 
ATOM   2846 C CB    . ARG A 1 520 ? 85.594  81.004  109.467 1.00 99.44  ? 494 ARG A CB    1 
ATOM   2847 C CG    . ARG A 1 520 ? 85.319  79.799  110.353 1.00 116.98 ? 494 ARG A CG    1 
ATOM   2848 C CD    . ARG A 1 520 ? 83.840  79.394  110.325 1.00 115.16 ? 494 ARG A CD    1 
ATOM   2849 N NE    . ARG A 1 520 ? 83.007  80.604  110.367 1.00 119.07 ? 494 ARG A NE    1 
ATOM   2850 C CZ    . ARG A 1 520 ? 82.169  81.044  109.422 1.00 131.74 ? 494 ARG A CZ    1 
ATOM   2851 N NH1   . ARG A 1 520 ? 82.075  80.444  108.246 1.00 140.33 ? 494 ARG A NH1   1 
ATOM   2852 N NH2   . ARG A 1 520 ? 81.418  82.106  109.661 1.00 153.03 ? 494 ARG A NH2   1 
ATOM   2853 N N     . TRP A 1 521 ? 87.262  81.989  106.831 1.00 63.50  ? 495 TRP A N     1 
ATOM   2854 C CA    . TRP A 1 521 ? 87.562  82.972  105.802 1.00 62.42  ? 495 TRP A CA    1 
ATOM   2855 C C     . TRP A 1 521 ? 86.384  83.940  105.784 1.00 63.11  ? 495 TRP A C     1 
ATOM   2856 O O     . TRP A 1 521 ? 86.575  85.144  105.653 1.00 65.67  ? 495 TRP A O     1 
ATOM   2857 C CB    . TRP A 1 521 ? 87.963  82.343  104.439 1.00 63.29  ? 495 TRP A CB    1 
ATOM   2858 C CG    . TRP A 1 521 ? 88.009  83.344  103.336 1.00 70.30  ? 495 TRP A CG    1 
ATOM   2859 C CD1   . TRP A 1 521 ? 87.053  83.538  102.383 1.00 115.56 ? 495 TRP A CD1   1 
ATOM   2860 C CD2   . TRP A 1 521 ? 88.847  84.497  103.258 1.00 80.93  ? 495 TRP A CD2   1 
ATOM   2861 N NE1   . TRP A 1 521 ? 87.237  84.704  101.689 1.00 87.95  ? 495 TRP A NE1   1 
ATOM   2862 C CE2   . TRP A 1 521 ? 88.333  85.317  102.215 1.00 94.04  ? 495 TRP A CE2   1 
ATOM   2863 C CE3   . TRP A 1 521 ? 89.961  84.914  103.968 1.00 69.20  ? 495 TRP A CE3   1 
ATOM   2864 C CZ2   . TRP A 1 521 ? 88.915  86.523  101.857 1.00 84.24  ? 495 TRP A CZ2   1 
ATOM   2865 C CZ3   . TRP A 1 521 ? 90.583  86.073  103.563 1.00 80.83  ? 495 TRP A CZ3   1 
ATOM   2866 C CH2   . TRP A 1 521 ? 90.037  86.884  102.562 1.00 99.42  ? 495 TRP A CH2   1 
ATOM   2867 N N     . ALA A 1 522 ? 85.176  83.454  106.041 1.00 59.03  ? 496 ALA A N     1 
ATOM   2868 C CA    . ALA A 1 522 ? 84.048  84.355  105.902 1.00 64.73  ? 496 ALA A CA    1 
ATOM   2869 C C     . ALA A 1 522 ? 84.127  85.533  106.851 1.00 71.35  ? 496 ALA A C     1 
ATOM   2870 O O     . ALA A 1 522 ? 83.461  86.553  106.652 1.00 93.43  ? 496 ALA A O     1 
ATOM   2871 C CB    . ALA A 1 522 ? 82.784  83.647  106.205 1.00 78.59  ? 496 ALA A CB    1 
ATOM   2872 N N     . GLN A 1 523 ? 84.826  85.330  107.954 1.00 76.44  ? 497 GLN A N     1 
ATOM   2873 C CA    . GLN A 1 523 ? 84.835  86.305  109.026 1.00 90.19  ? 497 GLN A CA    1 
ATOM   2874 C C     . GLN A 1 523 ? 86.047  87.209  108.851 1.00 82.49  ? 497 GLN A C     1 
ATOM   2875 O O     . GLN A 1 523 ? 85.948  88.430  109.003 1.00 76.54  ? 497 GLN A O     1 
ATOM   2876 C CB    . GLN A 1 523 ? 84.912  85.452  110.283 1.00 116.20 ? 497 GLN A CB    1 
ATOM   2877 C CG    . GLN A 1 523 ? 84.834  86.228  111.583 1.00 124.31 ? 497 GLN A CG    1 
ATOM   2878 C CD    . GLN A 1 523 ? 84.951  85.262  112.733 1.00 148.40 ? 497 GLN A CD    1 
ATOM   2879 O OE1   . GLN A 1 523 ? 85.430  84.124  112.567 1.00 116.18 ? 497 GLN A OE1   1 
ATOM   2880 N NE2   . GLN A 1 523 ? 84.504  85.718  113.896 1.00 162.18 ? 497 GLN A NE2   1 
ATOM   2881 N N     . LEU A 1 524 ? 87.176  86.572  108.498 1.00 68.73  ? 498 LEU A N     1 
ATOM   2882 C CA    . LEU A 1 524 ? 88.359  87.301  108.097 1.00 60.39  ? 498 LEU A CA    1 
ATOM   2883 C C     . LEU A 1 524 ? 87.962  88.425  107.151 1.00 67.27  ? 498 LEU A C     1 
ATOM   2884 O O     . LEU A 1 524 ? 87.985  89.591  107.542 1.00 76.28  ? 498 LEU A O     1 
ATOM   2885 C CB    . LEU A 1 524 ? 89.454  86.450  107.494 1.00 44.42  ? 498 LEU A CB    1 
ATOM   2886 C CG    . LEU A 1 524 ? 90.760  86.845  108.176 1.00 61.17  ? 498 LEU A CG    1 
ATOM   2887 C CD1   . LEU A 1 524 ? 91.985  85.953  107.977 1.00 71.99  ? 498 LEU A CD1   1 
ATOM   2888 C CD2   . LEU A 1 524 ? 91.010  88.200  107.658 1.00 67.91  ? 498 LEU A CD2   1 
ATOM   2889 N N     . SER A 1 525 ? 87.512  88.035  105.956 1.00 73.27  ? 499 SER A N     1 
ATOM   2890 C CA    . SER A 1 525 ? 87.343  88.950  104.841 1.00 73.87  ? 499 SER A CA    1 
ATOM   2891 C C     . SER A 1 525 ? 86.664  90.236  105.315 1.00 64.24  ? 499 SER A C     1 
ATOM   2892 O O     . SER A 1 525 ? 87.275  91.297  105.154 1.00 61.83  ? 499 SER A O     1 
ATOM   2893 C CB    . SER A 1 525 ? 86.629  88.295  103.698 1.00 86.67  ? 499 SER A CB    1 
ATOM   2894 O OG    . SER A 1 525 ? 85.223  88.439  103.875 1.00 121.01 ? 499 SER A OG    1 
ATOM   2895 N N     . GLU A 1 526 ? 85.472  90.169  105.932 1.00 51.03  ? 500 GLU A N     1 
ATOM   2896 C CA    . GLU A 1 526 ? 84.794  91.404  106.326 1.00 79.02  ? 500 GLU A CA    1 
ATOM   2897 C C     . GLU A 1 526 ? 85.621  92.349  107.230 1.00 91.16  ? 500 GLU A C     1 
ATOM   2898 O O     . GLU A 1 526 ? 85.335  93.554  107.333 1.00 69.73  ? 500 GLU A O     1 
ATOM   2899 C CB    . GLU A 1 526 ? 83.521  91.160  107.132 1.00 109.48 ? 500 GLU A CB    1 
ATOM   2900 C CG    . GLU A 1 526 ? 82.863  92.472  107.564 1.00 132.79 ? 500 GLU A CG    1 
ATOM   2901 C CD    . GLU A 1 526 ? 81.349  92.554  107.420 1.00 179.98 ? 500 GLU A CD    1 
ATOM   2902 O OE1   . GLU A 1 526 ? 80.650  91.700  108.020 1.00 202.20 ? 500 GLU A OE1   1 
ATOM   2903 O OE2   . GLU A 1 526 ? 80.872  93.482  106.706 1.00 152.84 ? 500 GLU A OE2   1 
ATOM   2904 N N     . VAL A 1 527 ? 86.597  91.801  107.968 1.00 79.53  ? 501 VAL A N     1 
ATOM   2905 C CA    . VAL A 1 527 ? 87.484  92.637  108.753 1.00 67.65  ? 501 VAL A CA    1 
ATOM   2906 C C     . VAL A 1 527 ? 88.568  93.261  107.864 1.00 76.26  ? 501 VAL A C     1 
ATOM   2907 O O     . VAL A 1 527 ? 88.713  94.491  107.900 1.00 66.15  ? 501 VAL A O     1 
ATOM   2908 C CB    . VAL A 1 527 ? 88.067  91.886  109.956 1.00 71.32  ? 501 VAL A CB    1 
ATOM   2909 C CG1   . VAL A 1 527 ? 89.326  92.545  110.502 1.00 74.12  ? 501 VAL A CG1   1 
ATOM   2910 C CG2   . VAL A 1 527 ? 87.039  91.873  111.059 1.00 74.92  ? 501 VAL A CG2   1 
ATOM   2911 N N     . LEU A 1 528 ? 89.325  92.432  107.096 1.00 59.57  ? 502 LEU A N     1 
ATOM   2912 C CA    . LEU A 1 528 ? 90.196  92.919  106.037 1.00 41.64  ? 502 LEU A CA    1 
ATOM   2913 C C     . LEU A 1 528 ? 89.524  94.061  105.296 1.00 52.94  ? 502 LEU A C     1 
ATOM   2914 O O     . LEU A 1 528 ? 90.104  95.135  105.259 1.00 63.23  ? 502 LEU A O     1 
ATOM   2915 C CB    . LEU A 1 528 ? 90.550  91.832  105.069 1.00 39.02  ? 502 LEU A CB    1 
ATOM   2916 C CG    . LEU A 1 528 ? 91.722  90.961  105.520 1.00 62.33  ? 502 LEU A CG    1 
ATOM   2917 C CD1   . LEU A 1 528 ? 92.415  89.985  104.495 1.00 67.94  ? 502 LEU A CD1   1 
ATOM   2918 C CD2   . LEU A 1 528 ? 92.783  91.863  106.054 1.00 63.49  ? 502 LEU A CD2   1 
ATOM   2919 N N     . SER A 1 529 ? 88.286  93.886  104.796 1.00 49.61  ? 503 SER A N     1 
ATOM   2920 C CA    . SER A 1 529 ? 87.567  95.037  104.267 1.00 55.51  ? 503 SER A CA    1 
ATOM   2921 C C     . SER A 1 529 ? 87.533  96.181  105.262 1.00 51.87  ? 503 SER A C     1 
ATOM   2922 O O     . SER A 1 529 ? 87.649  97.319  104.844 1.00 49.80  ? 503 SER A O     1 
ATOM   2923 C CB    . SER A 1 529 ? 86.124  94.824  103.904 1.00 70.74  ? 503 SER A CB    1 
ATOM   2924 O OG    . SER A 1 529 ? 85.537  96.098  103.610 1.00 59.98  ? 503 SER A OG    1 
ATOM   2925 N N     . TRP A 1 530 ? 87.222  95.920  106.534 1.00 58.09  ? 504 TRP A N     1 
ATOM   2926 C CA    . TRP A 1 530 ? 87.023  97.063  107.415 1.00 72.71  ? 504 TRP A CA    1 
ATOM   2927 C C     . TRP A 1 530 ? 88.294  97.899  107.463 1.00 61.58  ? 504 TRP A C     1 
ATOM   2928 O O     . TRP A 1 530 ? 88.240  99.125  107.500 1.00 48.35  ? 504 TRP A O     1 
ATOM   2929 C CB    . TRP A 1 530 ? 86.558  96.668  108.815 1.00 75.77  ? 504 TRP A CB    1 
ATOM   2930 C CG    . TRP A 1 530 ? 85.117  96.233  108.900 1.00 89.26  ? 504 TRP A CG    1 
ATOM   2931 C CD1   . TRP A 1 530 ? 84.093  96.551  108.068 1.00 116.52 ? 504 TRP A CD1   1 
ATOM   2932 C CD2   . TRP A 1 530 ? 84.532  95.419  109.934 1.00 96.11  ? 504 TRP A CD2   1 
ATOM   2933 N NE1   . TRP A 1 530 ? 82.930  95.970  108.490 1.00 103.53 ? 504 TRP A NE1   1 
ATOM   2934 C CE2   . TRP A 1 530 ? 83.175  95.284  109.636 1.00 85.08  ? 504 TRP A CE2   1 
ATOM   2935 C CE3   . TRP A 1 530 ? 85.032  94.800  111.081 1.00 110.93 ? 504 TRP A CE3   1 
ATOM   2936 C CZ2   . TRP A 1 530 ? 82.318  94.563  110.449 1.00 126.44 ? 504 TRP A CZ2   1 
ATOM   2937 C CZ3   . TRP A 1 530 ? 84.188  94.090  111.891 1.00 90.85  ? 504 TRP A CZ3   1 
ATOM   2938 C CH2   . TRP A 1 530 ? 82.848  93.976  111.575 1.00 122.86 ? 504 TRP A CH2   1 
ATOM   2939 N N     . GLN A 1 531 ? 89.423  97.212  107.317 1.00 62.38  ? 505 GLN A N     1 
ATOM   2940 C CA    . GLN A 1 531 ? 90.705  97.862  107.455 1.00 59.79  ? 505 GLN A CA    1 
ATOM   2941 C C     . GLN A 1 531 ? 90.776  99.026  106.494 1.00 50.88  ? 505 GLN A C     1 
ATOM   2942 O O     . GLN A 1 531 ? 91.142  100.083 106.968 1.00 68.39  ? 505 GLN A O     1 
ATOM   2943 C CB    . GLN A 1 531 ? 91.885  96.882  107.418 1.00 64.81  ? 505 GLN A CB    1 
ATOM   2944 C CG    . GLN A 1 531 ? 92.063  96.079  108.707 1.00 56.38  ? 505 GLN A CG    1 
ATOM   2945 C CD    . GLN A 1 531 ? 91.344  96.738  109.862 1.00 61.85  ? 505 GLN A CD    1 
ATOM   2946 O OE1   . GLN A 1 531 ? 91.599  97.895  110.215 1.00 59.03  ? 505 GLN A OE1   1 
ATOM   2947 N NE2   . GLN A 1 531 ? 90.340  96.045  110.367 1.00 66.43  ? 505 GLN A NE2   1 
ATOM   2948 N N     . PHE A 1 532 ? 90.341  98.876  105.232 1.00 53.13  ? 506 PHE A N     1 
ATOM   2949 C CA    . PHE A 1 532 ? 90.402  99.958  104.235 1.00 60.38  ? 506 PHE A CA    1 
ATOM   2950 C C     . PHE A 1 532 ? 89.250  100.982 104.365 1.00 56.25  ? 506 PHE A C     1 
ATOM   2951 O O     . PHE A 1 532 ? 89.431  102.204 104.316 1.00 50.32  ? 506 PHE A O     1 
ATOM   2952 C CB    . PHE A 1 532 ? 90.355  99.402  102.814 1.00 46.86  ? 506 PHE A CB    1 
ATOM   2953 C CG    . PHE A 1 532 ? 91.584  98.611  102.445 1.00 45.46  ? 506 PHE A CG    1 
ATOM   2954 C CD1   . PHE A 1 532 ? 91.866  97.390  103.019 1.00 52.80  ? 506 PHE A CD1   1 
ATOM   2955 C CD2   . PHE A 1 532 ? 92.440  99.061  101.474 1.00 58.91  ? 506 PHE A CD2   1 
ATOM   2956 C CE1   . PHE A 1 532 ? 92.998  96.642  102.660 1.00 56.11  ? 506 PHE A CE1   1 
ATOM   2957 C CE2   . PHE A 1 532 ? 93.570  98.320  101.126 1.00 68.38  ? 506 PHE A CE2   1 
ATOM   2958 C CZ    . PHE A 1 532 ? 93.837  97.101  101.713 1.00 65.06  ? 506 PHE A CZ    1 
ATOM   2959 N N     . SER A 1 533 ? 88.039  100.497 104.555 1.00 59.65  ? 507 SER A N     1 
ATOM   2960 C CA    . SER A 1 533 ? 86.903  101.380 104.736 1.00 76.73  ? 507 SER A CA    1 
ATOM   2961 C C     . SER A 1 533 ? 87.107  102.417 105.860 1.00 79.91  ? 507 SER A C     1 
ATOM   2962 O O     . SER A 1 533 ? 86.443  103.469 105.869 1.00 70.16  ? 507 SER A O     1 
ATOM   2963 C CB    . SER A 1 533 ? 85.646  100.551 104.942 1.00 86.87  ? 507 SER A CB    1 
ATOM   2964 O OG    . SER A 1 533 ? 85.781  99.622  106.013 1.00 90.45  ? 507 SER A OG    1 
ATOM   2965 N N     . SER A 1 534 ? 88.019  102.150 106.805 1.00 76.50  ? 508 SER A N     1 
ATOM   2966 C CA    . SER A 1 534 ? 88.111  102.981 108.003 1.00 97.90  ? 508 SER A CA    1 
ATOM   2967 C C     . SER A 1 534 ? 89.051  104.168 107.812 1.00 102.75 ? 508 SER A C     1 
ATOM   2968 O O     . SER A 1 534 ? 88.788  105.277 108.323 1.00 74.34  ? 508 SER A O     1 
ATOM   2969 C CB    . SER A 1 534 ? 88.609  102.192 109.146 1.00 101.12 ? 508 SER A CB    1 
ATOM   2970 O OG    . SER A 1 534 ? 89.965  101.846 108.890 1.00 99.81  ? 508 SER A OG    1 
ATOM   2971 N N     . VAL A 1 535 ? 90.173  103.827 107.152 1.00 80.88  ? 509 VAL A N     1 
ATOM   2972 C CA    . VAL A 1 535 ? 91.266  104.715 106.792 1.00 71.13  ? 509 VAL A CA    1 
ATOM   2973 C C     . VAL A 1 535 ? 90.993  105.534 105.531 1.00 95.07  ? 509 VAL A C     1 
ATOM   2974 O O     . VAL A 1 535 ? 91.445  106.687 105.445 1.00 84.64  ? 509 VAL A O     1 
ATOM   2975 C CB    . VAL A 1 535 ? 92.415  103.743 106.546 1.00 81.46  ? 509 VAL A CB    1 
ATOM   2976 C CG1   . VAL A 1 535 ? 93.353  104.165 105.405 1.00 70.13  ? 509 VAL A CG1   1 
ATOM   2977 C CG2   . VAL A 1 535 ? 93.119  103.477 107.874 1.00 111.77 ? 509 VAL A CG2   1 
ATOM   2978 N N     . THR A 1 536 ? 90.319  104.929 104.533 1.00 84.30  ? 510 THR A N     1 
ATOM   2979 C CA    . THR A 1 536 ? 89.966  105.684 103.343 1.00 89.09  ? 510 THR A CA    1 
ATOM   2980 C C     . THR A 1 536 ? 88.464  105.936 103.337 1.00 94.61  ? 510 THR A C     1 
ATOM   2981 O O     . THR A 1 536 ? 87.902  106.252 104.392 1.00 84.04  ? 510 THR A O     1 
ATOM   2982 C CB    . THR A 1 536 ? 90.441  104.990 102.065 1.00 95.58  ? 510 THR A CB    1 
ATOM   2983 O OG1   . THR A 1 536 ? 89.510  104.002 101.657 1.00 99.93  ? 510 THR A OG1   1 
ATOM   2984 C CG2   . THR A 1 536 ? 91.790  104.320 102.214 1.00 115.42 ? 510 THR A CG2   1 
ATOM   2985 N N     . LYS A 1 537 ? 87.876  105.827 102.125 1.00 82.27  ? 511 LYS A N     1 
ATOM   2986 C CA    . LYS A 1 537 ? 86.477  106.097 101.861 1.00 71.31  ? 511 LYS A CA    1 
ATOM   2987 C C     . LYS A 1 537 ? 85.916  105.071 100.893 1.00 65.52  ? 511 LYS A C     1 
ATOM   2988 O O     . LYS A 1 537 ? 84.996  105.364 100.135 1.00 91.66  ? 511 LYS A O     1 
ATOM   2989 C CB    . LYS A 1 537 ? 86.378  107.492 101.242 1.00 88.96  ? 511 LYS A CB    1 
ATOM   2990 C CG    . LYS A 1 537 ? 85.032  108.149 101.409 1.00 122.56 ? 511 LYS A CG    1 
ATOM   2991 C CD    . LYS A 1 537 ? 84.897  109.487 100.690 1.00 145.61 ? 511 LYS A CD    1 
ATOM   2992 C CE    . LYS A 1 537 ? 85.851  110.533 101.166 1.00 140.56 ? 511 LYS A CE    1 
ATOM   2993 N NZ    . LYS A 1 537 ? 85.821  110.686 102.622 1.00 133.08 ? 511 LYS A NZ    1 
ATOM   2994 N N     . ARG A 1 538 ? 86.454  103.858 100.947 1.00 66.02  ? 512 ARG A N     1 
ATOM   2995 C CA    . ARG A 1 538 ? 86.030  102.764 100.092 1.00 67.62  ? 512 ARG A CA    1 
ATOM   2996 C C     . ARG A 1 538 ? 86.717  101.465 100.504 1.00 64.01  ? 512 ARG A C     1 
ATOM   2997 O O     . ARG A 1 538 ? 87.930  101.379 100.497 1.00 88.22  ? 512 ARG A O     1 
ATOM   2998 C CB    . ARG A 1 538 ? 86.558  103.128 98.707  1.00 83.74  ? 512 ARG A CB    1 
ATOM   2999 C CG    . ARG A 1 538 ? 86.290  102.031 97.691  1.00 105.33 ? 512 ARG A CG    1 
ATOM   3000 C CD    . ARG A 1 538 ? 86.883  102.296 96.324  1.00 110.18 ? 512 ARG A CD    1 
ATOM   3001 N NE    . ARG A 1 538 ? 85.822  102.094 95.333  1.00 100.65 ? 512 ARG A NE    1 
ATOM   3002 C CZ    . ARG A 1 538 ? 84.981  103.042 94.934  1.00 123.26 ? 512 ARG A CZ    1 
ATOM   3003 N NH1   . ARG A 1 538 ? 85.142  104.317 95.280  1.00 104.69 ? 512 ARG A NH1   1 
ATOM   3004 N NH2   . ARG A 1 538 ? 83.992  102.699 94.126  1.00 163.34 ? 512 ARG A NH2   1 
ATOM   3005 N N     . GLY A 1 539 ? 85.987  100.408 100.805 1.00 71.25  ? 513 GLY A N     1 
ATOM   3006 C CA    . GLY A 1 539 ? 86.667  99.168  101.164 1.00 69.25  ? 513 GLY A CA    1 
ATOM   3007 C C     . GLY A 1 539 ? 86.906  98.226  99.984  1.00 62.49  ? 513 GLY A C     1 
ATOM   3008 O O     . GLY A 1 539 ? 86.951  98.638  98.823  1.00 74.98  ? 513 GLY A O     1 
ATOM   3009 N N     . LEU A 1 540 ? 87.031  96.937  100.303 1.00 67.22  ? 514 LEU A N     1 
ATOM   3010 C CA    . LEU A 1 540 ? 87.540  95.937  99.373  1.00 74.14  ? 514 LEU A CA    1 
ATOM   3011 C C     . LEU A 1 540 ? 86.368  95.243  98.721  1.00 89.92  ? 514 LEU A C     1 
ATOM   3012 O O     . LEU A 1 540 ? 85.625  94.538  99.402  1.00 113.58 ? 514 LEU A O     1 
ATOM   3013 C CB    . LEU A 1 540 ? 88.353  94.866  100.090 1.00 77.16  ? 514 LEU A CB    1 
ATOM   3014 C CG    . LEU A 1 540 ? 89.671  95.314  100.709 1.00 74.46  ? 514 LEU A CG    1 
ATOM   3015 C CD1   . LEU A 1 540 ? 90.486  94.043  100.621 1.00 80.88  ? 514 LEU A CD1   1 
ATOM   3016 C CD2   . LEU A 1 540 ? 90.353  96.515  100.021 1.00 68.66  ? 514 LEU A CD2   1 
ATOM   3017 N N     . ASN A 1 541 ? 86.238  95.423  97.412  1.00 100.41 ? 515 ASN A N     1 
ATOM   3018 C CA    . ASN A 1 541 ? 85.133  94.839  96.678  1.00 100.35 ? 515 ASN A CA    1 
ATOM   3019 C C     . ASN A 1 541 ? 85.299  93.328  96.609  1.00 74.42  ? 515 ASN A C     1 
ATOM   3020 O O     . ASN A 1 541 ? 86.296  92.794  97.083  1.00 60.69  ? 515 ASN A O     1 
ATOM   3021 C CB    . ASN A 1 541 ? 85.122  95.318  95.240  1.00 113.50 ? 515 ASN A CB    1 
ATOM   3022 C CG    . ASN A 1 541 ? 86.220  94.649  94.438  1.00 85.91  ? 515 ASN A CG    1 
ATOM   3023 O OD1   . ASN A 1 541 ? 86.306  93.413  94.337  1.00 68.21  ? 515 ASN A OD1   1 
ATOM   3024 N ND2   . ASN A 1 541 ? 87.043  95.476  93.818  1.00 89.20  ? 515 ASN A ND2   1 
ATOM   3025 N N     . VAL A 1 542 ? 84.381  92.688  95.884  1.00 72.10  ? 516 VAL A N     1 
ATOM   3026 C CA    . VAL A 1 542 ? 84.322  91.243  95.855  1.00 93.63  ? 516 VAL A CA    1 
ATOM   3027 C C     . VAL A 1 542 ? 85.510  90.600  95.138  1.00 96.27  ? 516 VAL A C     1 
ATOM   3028 O O     . VAL A 1 542 ? 86.027  89.568  95.576  1.00 72.98  ? 516 VAL A O     1 
ATOM   3029 C CB    . VAL A 1 542 ? 83.028  90.808  95.168  1.00 98.27  ? 516 VAL A CB    1 
ATOM   3030 C CG1   . VAL A 1 542 ? 82.931  89.280  95.234  1.00 95.52  ? 516 VAL A CG1   1 
ATOM   3031 C CG2   . VAL A 1 542 ? 81.828  91.556  95.748  1.00 93.05  ? 516 VAL A CG2   1 
ATOM   3032 N N     . ASP A 1 543 ? 85.863  91.128  93.966  1.00 96.28  ? 517 ASP A N     1 
ATOM   3033 C CA    . ASP A 1 543 ? 86.823  90.402  93.167  1.00 103.99 ? 517 ASP A CA    1 
ATOM   3034 C C     . ASP A 1 543 ? 88.179  90.531  93.835  1.00 97.09  ? 517 ASP A C     1 
ATOM   3035 O O     . ASP A 1 543 ? 88.965  89.577  93.833  1.00 88.06  ? 517 ASP A O     1 
ATOM   3036 C CB    . ASP A 1 543 ? 86.743  90.787  91.706  1.00 154.53 ? 517 ASP A CB    1 
ATOM   3037 C CG    . ASP A 1 543 ? 85.969  89.795  90.846  1.00 221.74 ? 517 ASP A CG    1 
ATOM   3038 O OD1   . ASP A 1 543 ? 85.615  88.709  91.363  1.00 211.93 ? 517 ASP A OD1   1 
ATOM   3039 O OD2   . ASP A 1 543 ? 85.727  90.112  89.660  1.00 285.54 ? 517 ASP A OD2   1 
ATOM   3040 N N     . GLN A 1 544 ? 88.394  91.701  94.454  1.00 77.69  ? 518 GLN A N     1 
ATOM   3041 C CA    . GLN A 1 544 ? 89.580  91.940  95.259  1.00 66.70  ? 518 GLN A CA    1 
ATOM   3042 C C     . GLN A 1 544 ? 89.713  90.867  96.346  1.00 73.10  ? 518 GLN A C     1 
ATOM   3043 O O     . GLN A 1 544 ? 90.735  90.167  96.449  1.00 60.52  ? 518 GLN A O     1 
ATOM   3044 C CB    . GLN A 1 544 ? 89.544  93.355  95.809  1.00 59.83  ? 518 GLN A CB    1 
ATOM   3045 C CG    . GLN A 1 544 ? 90.060  94.409  94.844  1.00 58.37  ? 518 GLN A CG    1 
ATOM   3046 C CD    . GLN A 1 544 ? 89.549  95.778  95.252  1.00 67.45  ? 518 GLN A CD    1 
ATOM   3047 O OE1   . GLN A 1 544 ? 88.535  95.870  95.956  1.00 70.77  ? 518 GLN A OE1   1 
ATOM   3048 N NE2   . GLN A 1 544 ? 90.220  96.857  94.847  1.00 72.18  ? 518 GLN A NE2   1 
ATOM   3049 N N     . LEU A 1 545 ? 88.631  90.674  97.106  1.00 68.53  ? 519 LEU A N     1 
ATOM   3050 C CA    . LEU A 1 545 ? 88.689  89.751  98.224  1.00 64.98  ? 519 LEU A CA    1 
ATOM   3051 C C     . LEU A 1 545 ? 89.065  88.348  97.806  1.00 68.92  ? 519 LEU A C     1 
ATOM   3052 O O     . LEU A 1 545 ? 90.014  87.827  98.414  1.00 48.93  ? 519 LEU A O     1 
ATOM   3053 C CB    . LEU A 1 545 ? 87.387  89.843  98.965  1.00 55.16  ? 519 LEU A CB    1 
ATOM   3054 C CG    . LEU A 1 545 ? 87.469  91.040  99.925  1.00 74.47  ? 519 LEU A CG    1 
ATOM   3055 C CD1   . LEU A 1 545 ? 86.111  91.619  100.377 1.00 89.19  ? 519 LEU A CD1   1 
ATOM   3056 C CD2   . LEU A 1 545 ? 88.358  90.630  101.123 1.00 70.09  ? 519 LEU A CD2   1 
ATOM   3057 N N     . ASN A 1 546 ? 88.455  87.880  96.694  1.00 71.87  ? 520 ASN A N     1 
ATOM   3058 C CA    . ASN A 1 546 ? 88.798  86.607  96.075  1.00 85.50  ? 520 ASN A CA    1 
ATOM   3059 C C     . ASN A 1 546 ? 90.272  86.471  95.760  1.00 80.44  ? 520 ASN A C     1 
ATOM   3060 O O     . ASN A 1 546 ? 90.742  85.327  95.778  1.00 71.18  ? 520 ASN A O     1 
ATOM   3061 C CB    . ASN A 1 546 ? 88.187  86.337  94.715  1.00 97.52  ? 520 ASN A CB    1 
ATOM   3062 C CG    . ASN A 1 546 ? 86.724  86.016  94.833  1.00 129.57 ? 520 ASN A CG    1 
ATOM   3063 O OD1   . ASN A 1 546 ? 85.941  86.837  95.339  1.00 146.59 ? 520 ASN A OD1   1 
ATOM   3064 N ND2   . ASN A 1 546 ? 86.358  84.822  94.386  1.00 118.78 ? 520 ASN A ND2   1 
ATOM   3065 N N     . MET A 1 547 ? 90.964  87.590  95.467  1.00 62.20  ? 521 MET A N     1 
ATOM   3066 C CA    . MET A 1 547 ? 92.403  87.468  95.281  1.00 79.51  ? 521 MET A CA    1 
ATOM   3067 C C     . MET A 1 547 ? 93.093  87.158  96.620  1.00 88.66  ? 521 MET A C     1 
ATOM   3068 O O     . MET A 1 547 ? 93.950  86.257  96.719  1.00 73.08  ? 521 MET A O     1 
ATOM   3069 C CB    . MET A 1 547 ? 93.024  88.695  94.607  1.00 82.46  ? 521 MET A CB    1 
ATOM   3070 C CG    . MET A 1 547 ? 94.381  88.384  93.941  1.00 105.52 ? 521 MET A CG    1 
ATOM   3071 S SD    . MET A 1 547 ? 95.889  88.556  94.932  1.00 108.10 ? 521 MET A SD    1 
ATOM   3072 C CE    . MET A 1 547 ? 95.510  90.297  95.060  1.00 74.05  ? 521 MET A CE    1 
ATOM   3073 N N     . LEU A 1 548 ? 92.709  87.890  97.676  1.00 69.06  ? 522 LEU A N     1 
ATOM   3074 C CA    . LEU A 1 548 ? 93.392  87.665  98.928  1.00 55.91  ? 522 LEU A CA    1 
ATOM   3075 C C     . LEU A 1 548 ? 92.863  86.366  99.503  1.00 63.79  ? 522 LEU A C     1 
ATOM   3076 O O     . LEU A 1 548 ? 93.588  85.665  100.188 1.00 67.07  ? 522 LEU A O     1 
ATOM   3077 C CB    . LEU A 1 548 ? 93.182  88.812  99.883  1.00 51.41  ? 522 LEU A CB    1 
ATOM   3078 C CG    . LEU A 1 548 ? 93.366  90.188  99.271  1.00 51.00  ? 522 LEU A CG    1 
ATOM   3079 C CD1   . LEU A 1 548 ? 92.716  91.289  100.069 1.00 61.39  ? 522 LEU A CD1   1 
ATOM   3080 C CD2   . LEU A 1 548 ? 94.843  90.345  99.179  1.00 53.00  ? 522 LEU A CD2   1 
ATOM   3081 N N     . GLY A 1 549 ? 91.605  86.025  99.190  1.00 67.51  ? 523 GLY A N     1 
ATOM   3082 C CA    . GLY A 1 549 ? 91.135  84.663  99.410  1.00 68.89  ? 523 GLY A CA    1 
ATOM   3083 C C     . GLY A 1 549 ? 92.283  83.696  99.132  1.00 92.41  ? 523 GLY A C     1 
ATOM   3084 O O     . GLY A 1 549 ? 92.841  82.989  99.990  1.00 86.94  ? 523 GLY A O     1 
ATOM   3085 N N     . GLU A 1 550 ? 92.689  83.754  97.884  1.00 87.68  ? 524 GLU A N     1 
ATOM   3086 C CA    . GLU A 1 550 ? 93.366  82.624  97.329  1.00 87.60  ? 524 GLU A CA    1 
ATOM   3087 C C     . GLU A 1 550 ? 94.795  82.727  97.800  1.00 81.01  ? 524 GLU A C     1 
ATOM   3088 O O     . GLU A 1 550 ? 95.492  81.720  97.826  1.00 120.54 ? 524 GLU A O     1 
ATOM   3089 C CB    . GLU A 1 550 ? 93.011  82.637  95.845  1.00 127.49 ? 524 GLU A CB    1 
ATOM   3090 C CG    . GLU A 1 550 ? 93.844  81.692  94.992  1.00 168.90 ? 524 GLU A CG    1 
ATOM   3091 C CD    . GLU A 1 550 ? 95.256  82.199  94.732  1.00 234.43 ? 524 GLU A CD    1 
ATOM   3092 O OE1   . GLU A 1 550 ? 96.219  81.435  94.973  1.00 265.79 ? 524 GLU A OE1   1 
ATOM   3093 O OE2   . GLU A 1 550 ? 95.398  83.366  94.300  1.00 262.78 ? 524 GLU A OE2   1 
ATOM   3094 N N     . LYS A 1 551 ? 95.260  83.915  98.176  1.00 74.83  ? 525 LYS A N     1 
ATOM   3095 C CA    . LYS A 1 551 ? 96.629  83.933  98.679  1.00 97.65  ? 525 LYS A CA    1 
ATOM   3096 C C     . LYS A 1 551 ? 96.760  83.062  99.938  1.00 102.87 ? 525 LYS A C     1 
ATOM   3097 O O     . LYS A 1 551 ? 97.747  82.346  100.069 1.00 123.83 ? 525 LYS A O     1 
ATOM   3098 C CB    . LYS A 1 551 ? 97.204  85.317  98.999  1.00 93.35  ? 525 LYS A CB    1 
ATOM   3099 C CG    . LYS A 1 551 ? 97.800  86.022  97.830  1.00 91.89  ? 525 LYS A CG    1 
ATOM   3100 C CD    . LYS A 1 551 ? 99.115  86.730  98.124  1.00 81.03  ? 525 LYS A CD    1 
ATOM   3101 C CE    . LYS A 1 551 ? 98.938  88.106  98.762  1.00 91.66  ? 525 LYS A CE    1 
ATOM   3102 N NZ    . LYS A 1 551 ? 100.244 88.806  98.839  1.00 95.89  ? 525 LYS A NZ    1 
ATOM   3103 N N     . LEU A 1 552 ? 95.767  83.131  100.845 1.00 89.63  ? 526 LEU A N     1 
ATOM   3104 C CA    . LEU A 1 552 ? 95.833  82.518  102.162 1.00 78.45  ? 526 LEU A CA    1 
ATOM   3105 C C     . LEU A 1 552 ? 95.416  81.053  102.065 1.00 113.61 ? 526 LEU A C     1 
ATOM   3106 O O     . LEU A 1 552 ? 96.043  80.158  102.667 1.00 103.12 ? 526 LEU A O     1 
ATOM   3107 C CB    . LEU A 1 552 ? 94.918  83.311  103.089 1.00 73.58  ? 526 LEU A CB    1 
ATOM   3108 C CG    . LEU A 1 552 ? 95.461  84.694  103.465 1.00 75.08  ? 526 LEU A CG    1 
ATOM   3109 C CD1   . LEU A 1 552 ? 94.475  85.633  104.094 1.00 63.14  ? 526 LEU A CD1   1 
ATOM   3110 C CD2   . LEU A 1 552 ? 96.600  84.523  104.402 1.00 87.82  ? 526 LEU A CD2   1 
ATOM   3111 N N     . LEU A 1 553 ? 94.394  80.816  101.228 1.00 101.62 ? 527 LEU A N     1 
ATOM   3112 C CA    . LEU A 1 553 ? 93.636  79.585  101.329 1.00 94.19  ? 527 LEU A CA    1 
ATOM   3113 C C     . LEU A 1 553 ? 93.975  78.532  100.290 1.00 98.50  ? 527 LEU A C     1 
ATOM   3114 O O     . LEU A 1 553 ? 93.764  77.352  100.555 1.00 135.53 ? 527 LEU A O     1 
ATOM   3115 C CB    . LEU A 1 553 ? 92.162  79.948  101.308 1.00 74.66  ? 527 LEU A CB    1 
ATOM   3116 C CG    . LEU A 1 553 ? 91.664  80.206  102.729 1.00 82.57  ? 527 LEU A CG    1 
ATOM   3117 C CD1   . LEU A 1 553 ? 90.182  80.576  102.843 1.00 80.69  ? 527 LEU A CD1   1 
ATOM   3118 C CD2   . LEU A 1 553 ? 92.036  78.970  103.569 1.00 75.33  ? 527 LEU A CD2   1 
ATOM   3119 N N     . GLY A 1 554 ? 94.445  78.953  99.122  1.00 93.04  ? 528 GLY A N     1 
ATOM   3120 C CA    . GLY A 1 554 ? 94.560  78.055  97.989  1.00 98.18  ? 528 GLY A CA    1 
ATOM   3121 C C     . GLY A 1 554 ? 93.507  78.313  96.906  1.00 120.20 ? 528 GLY A C     1 
ATOM   3122 O O     . GLY A 1 554 ? 92.684  79.231  96.985  1.00 126.59 ? 528 GLY A O     1 
ATOM   3123 N N     . PRO A 1 555 ? 93.564  77.528  95.809  1.00 130.40 ? 529 PRO A N     1 
ATOM   3124 C CA    . PRO A 1 555 ? 92.548  77.581  94.746  1.00 114.61 ? 529 PRO A CA    1 
ATOM   3125 C C     . PRO A 1 555 ? 91.089  77.402  95.162  1.00 140.35 ? 529 PRO A C     1 
ATOM   3126 O O     . PRO A 1 555 ? 90.175  77.859  94.482  1.00 138.91 ? 529 PRO A O     1 
ATOM   3127 C CB    . PRO A 1 555 ? 93.003  76.383  93.920  1.00 130.91 ? 529 PRO A CB    1 
ATOM   3128 C CG    . PRO A 1 555 ? 94.513  76.328  94.106  1.00 136.48 ? 529 PRO A CG    1 
ATOM   3129 C CD    . PRO A 1 555 ? 94.676  76.592  95.552  1.00 129.89 ? 529 PRO A CD    1 
ATOM   3130 N N     . ASN A 1 556 ? 90.893  76.667  96.264  1.00 183.94 ? 530 ASN A N     1 
ATOM   3131 C CA    . ASN A 1 556 ? 89.582  76.301  96.779  1.00 178.11 ? 530 ASN A CA    1 
ATOM   3132 C C     . ASN A 1 556 ? 89.254  77.190  97.980  1.00 149.09 ? 530 ASN A C     1 
ATOM   3133 O O     . ASN A 1 556 ? 89.346  76.770  99.134  1.00 121.92 ? 530 ASN A O     1 
ATOM   3134 C CB    . ASN A 1 556 ? 89.573  74.813  97.119  1.00 191.91 ? 530 ASN A CB    1 
ATOM   3135 C CG    . ASN A 1 556 ? 88.233  74.326  97.619  1.00 203.64 ? 530 ASN A CG    1 
ATOM   3136 O OD1   . ASN A 1 556 ? 87.277  75.106  97.690  1.00 248.68 ? 530 ASN A OD1   1 
ATOM   3137 N ND2   . ASN A 1 556 ? 88.137  73.049  97.969  1.00 186.83 ? 530 ASN A ND2   1 
ATOM   3138 N N     . ALA A 1 557 ? 88.889  78.440  97.707  1.00 123.25 ? 531 ALA A N     1 
ATOM   3139 C CA    . ALA A 1 557 ? 88.796  79.416  98.775  1.00 121.37 ? 531 ALA A CA    1 
ATOM   3140 C C     . ALA A 1 557 ? 87.350  79.489  99.244  1.00 134.72 ? 531 ALA A C     1 
ATOM   3141 O O     . ALA A 1 557 ? 86.619  80.456  98.980  1.00 148.41 ? 531 ALA A O     1 
ATOM   3142 C CB    . ALA A 1 557 ? 89.307  80.752  98.298  1.00 178.61 ? 531 ALA A CB    1 
ATOM   3143 N N     . SER A 1 558 ? 86.950  78.423  99.932  1.00 105.78 ? 532 SER A N     1 
ATOM   3144 C CA    . SER A 1 558 ? 85.599  78.311  100.448 1.00 114.24 ? 532 SER A CA    1 
ATOM   3145 C C     . SER A 1 558 ? 85.376  79.426  101.468 1.00 96.90  ? 532 SER A C     1 
ATOM   3146 O O     . SER A 1 558 ? 86.358  79.952  101.982 1.00 122.09 ? 532 SER A O     1 
ATOM   3147 C CB    . SER A 1 558 ? 85.438  76.935  101.027 1.00 138.43 ? 532 SER A CB    1 
ATOM   3148 O OG    . SER A 1 558 ? 86.666  76.507  101.622 1.00 136.75 ? 532 SER A OG    1 
ATOM   3149 N N     . PRO A 1 559 ? 84.135  79.821  101.850 1.00 95.78  ? 533 PRO A N     1 
ATOM   3150 C CA    . PRO A 1 559 ? 83.952  80.857  102.867 1.00 103.60 ? 533 PRO A CA    1 
ATOM   3151 C C     . PRO A 1 559 ? 84.009  80.237  104.265 1.00 94.11  ? 533 PRO A C     1 
ATOM   3152 O O     . PRO A 1 559 ? 83.790  80.888  105.276 1.00 102.11 ? 533 PRO A O     1 
ATOM   3153 C CB    . PRO A 1 559 ? 82.602  81.531  102.469 1.00 93.84  ? 533 PRO A CB    1 
ATOM   3154 C CG    . PRO A 1 559 ? 81.855  80.409  101.823 1.00 127.08 ? 533 PRO A CG    1 
ATOM   3155 C CD    . PRO A 1 559 ? 82.851  79.315  101.367 1.00 119.11 ? 533 PRO A CD    1 
ATOM   3156 N N     . ASP A 1 560 ? 84.419  78.981  104.312 1.00 93.69  ? 534 ASP A N     1 
ATOM   3157 C CA    . ASP A 1 560 ? 84.545  78.264  105.557 1.00 93.77  ? 534 ASP A CA    1 
ATOM   3158 C C     . ASP A 1 560 ? 86.014  77.989  105.879 1.00 102.66 ? 534 ASP A C     1 
ATOM   3159 O O     . ASP A 1 560 ? 86.352  77.798  107.046 1.00 122.10 ? 534 ASP A O     1 
ATOM   3160 C CB    . ASP A 1 560 ? 83.741  76.989  105.468 1.00 120.36 ? 534 ASP A CB    1 
ATOM   3161 C CG    . ASP A 1 560 ? 84.081  75.953  106.524 1.00 164.45 ? 534 ASP A CG    1 
ATOM   3162 O OD1   . ASP A 1 560 ? 83.950  76.277  107.732 1.00 184.05 ? 534 ASP A OD1   1 
ATOM   3163 O OD2   . ASP A 1 560 ? 84.489  74.842  106.121 1.00 183.77 ? 534 ASP A OD2   1 
ATOM   3164 N N     . GLY A 1 561 ? 86.887  77.975  104.862 1.00 93.11  ? 535 GLY A N     1 
ATOM   3165 C CA    . GLY A 1 561 ? 88.300  77.703  105.062 1.00 95.86  ? 535 GLY A CA    1 
ATOM   3166 C C     . GLY A 1 561 ? 88.855  78.323  106.352 1.00 94.41  ? 535 GLY A C     1 
ATOM   3167 O O     . GLY A 1 561 ? 88.454  79.399  106.799 1.00 81.91  ? 535 GLY A O     1 
ATOM   3168 N N     . LEU A 1 562 ? 89.818  77.630  106.955 1.00 92.27  ? 536 LEU A N     1 
ATOM   3169 C CA    . LEU A 1 562 ? 90.397  78.097  108.197 1.00 98.16  ? 536 LEU A CA    1 
ATOM   3170 C C     . LEU A 1 562 ? 91.798  78.672  107.992 1.00 80.36  ? 536 LEU A C     1 
ATOM   3171 O O     . LEU A 1 562 ? 92.745  77.989  107.608 1.00 87.81  ? 536 LEU A O     1 
ATOM   3172 C CB    . LEU A 1 562 ? 90.356  76.868  109.087 1.00 95.35  ? 536 LEU A CB    1 
ATOM   3173 C CG    . LEU A 1 562 ? 88.944  76.336  109.308 1.00 99.24  ? 536 LEU A CG    1 
ATOM   3174 C CD1   . LEU A 1 562 ? 89.057  74.837  109.475 1.00 124.23 ? 536 LEU A CD1   1 
ATOM   3175 C CD2   . LEU A 1 562 ? 88.294  77.031  110.504 1.00 115.22 ? 536 LEU A CD2   1 
ATOM   3176 N N     . ILE A 1 563 ? 91.907  79.951  108.280 1.00 55.09  ? 537 ILE A N     1 
ATOM   3177 C CA    . ILE A 1 563 ? 93.175  80.612  108.239 1.00 47.50  ? 537 ILE A CA    1 
ATOM   3178 C C     . ILE A 1 563 ? 93.679  80.542  109.647 1.00 59.81  ? 537 ILE A C     1 
ATOM   3179 O O     . ILE A 1 563 ? 93.059  81.156  110.514 1.00 81.09  ? 537 ILE A O     1 
ATOM   3180 C CB    . ILE A 1 563 ? 92.999  82.099  107.897 1.00 59.32  ? 537 ILE A CB    1 
ATOM   3181 C CG1   . ILE A 1 563 ? 92.318  82.331  106.608 1.00 55.41  ? 537 ILE A CG1   1 
ATOM   3182 C CG2   . ILE A 1 563 ? 94.355  82.790  107.867 1.00 82.68  ? 537 ILE A CG2   1 
ATOM   3183 C CD1   . ILE A 1 563 ? 90.853  81.992  106.624 1.00 59.21  ? 537 ILE A CD1   1 
ATOM   3184 N N     . PRO A 1 564 ? 94.780  79.825  109.913 1.00 66.17  ? 538 PRO A N     1 
ATOM   3185 C CA    . PRO A 1 564 ? 95.470  79.835  111.219 1.00 73.02  ? 538 PRO A CA    1 
ATOM   3186 C C     . PRO A 1 564 ? 96.285  81.070  111.477 1.00 64.65  ? 538 PRO A C     1 
ATOM   3187 O O     . PRO A 1 564 ? 96.820  81.625  110.537 1.00 92.88  ? 538 PRO A O     1 
ATOM   3188 C CB    . PRO A 1 564 ? 96.459  78.709  111.148 1.00 78.54  ? 538 PRO A CB    1 
ATOM   3189 C CG    . PRO A 1 564 ? 95.883  77.883  110.042 1.00 98.02  ? 538 PRO A CG    1 
ATOM   3190 C CD    . PRO A 1 564 ? 95.345  78.870  108.979 1.00 76.07  ? 538 PRO A CD    1 
ATOM   3191 N N     . TRP A 1 565 ? 96.565  81.337  112.740 1.00 68.59  ? 539 TRP A N     1 
ATOM   3192 C CA    . TRP A 1 565 ? 97.192  82.598  113.105 1.00 65.26  ? 539 TRP A CA    1 
ATOM   3193 C C     . TRP A 1 565 ? 98.646  82.644  112.676 1.00 69.57  ? 539 TRP A C     1 
ATOM   3194 O O     . TRP A 1 565 ? 99.198  83.712  112.442 1.00 83.62  ? 539 TRP A O     1 
ATOM   3195 C CB    . TRP A 1 565 ? 97.126  82.771  114.607 1.00 64.59  ? 539 TRP A CB    1 
ATOM   3196 C CG    . TRP A 1 565 ? 98.106  83.725  115.171 1.00 53.87  ? 539 TRP A CG    1 
ATOM   3197 C CD1   . TRP A 1 565 ? 99.230  83.494  115.890 1.00 67.05  ? 539 TRP A CD1   1 
ATOM   3198 C CD2   . TRP A 1 565 ? 97.937  85.129  115.140 1.00 62.94  ? 539 TRP A CD2   1 
ATOM   3199 N NE1   . TRP A 1 565 ? 99.815  84.677  116.264 1.00 61.52  ? 539 TRP A NE1   1 
ATOM   3200 C CE2   . TRP A 1 565 ? 99.051  85.698  115.813 1.00 61.27  ? 539 TRP A CE2   1 
ATOM   3201 C CE3   . TRP A 1 565 ? 96.936  85.942  114.612 1.00 63.58  ? 539 TRP A CE3   1 
ATOM   3202 C CZ2   . TRP A 1 565 ? 99.203  87.063  115.987 1.00 67.13  ? 539 TRP A CZ2   1 
ATOM   3203 C CZ3   . TRP A 1 565 ? 97.088  87.314  114.796 1.00 74.13  ? 539 TRP A CZ3   1 
ATOM   3204 C CH2   . TRP A 1 565 ? 98.189  87.866  115.496 1.00 61.65  ? 539 TRP A CH2   1 
ATOM   3205 N N     . THR A 1 566 ? 99.293  81.500  112.581 1.00 75.29  ? 540 THR A N     1 
ATOM   3206 C CA    . THR A 1 566 ? 100.597 81.569  111.971 1.00 79.17  ? 540 THR A CA    1 
ATOM   3207 C C     . THR A 1 566 ? 100.338 82.190  110.623 1.00 67.07  ? 540 THR A C     1 
ATOM   3208 O O     . THR A 1 566 ? 100.957 83.189  110.298 1.00 110.73 ? 540 THR A O     1 
ATOM   3209 C CB    . THR A 1 566 ? 101.278 80.211  111.851 1.00 119.76 ? 540 THR A CB    1 
ATOM   3210 O OG1   . THR A 1 566 ? 100.244 79.321  111.427 1.00 125.83 ? 540 THR A OG1   1 
ATOM   3211 C CG2   . THR A 1 566 ? 101.923 79.797  113.161 1.00 141.77 ? 540 THR A CG2   1 
ATOM   3212 N N     . ARG A 1 567 ? 99.398  81.628  109.863 1.00 64.62  ? 541 ARG A N     1 
ATOM   3213 C CA    . ARG A 1 567 ? 99.395  81.882  108.427 1.00 66.94  ? 541 ARG A CA    1 
ATOM   3214 C C     . ARG A 1 567 ? 99.150  83.346  108.156 1.00 56.38  ? 541 ARG A C     1 
ATOM   3215 O O     . ARG A 1 567 ? 99.850  83.975  107.382 1.00 75.73  ? 541 ARG A O     1 
ATOM   3216 C CB    . ARG A 1 567 ? 98.352  81.139  107.611 1.00 76.27  ? 541 ARG A CB    1 
ATOM   3217 C CG    . ARG A 1 567 ? 98.843  80.966  106.187 1.00 90.53  ? 541 ARG A CG    1 
ATOM   3218 C CD    . ARG A 1 567 ? 97.968  80.016  105.333 1.00 123.85 ? 541 ARG A CD    1 
ATOM   3219 N NE    . ARG A 1 567 ? 98.787  79.016  104.633 1.00 162.94 ? 541 ARG A NE    1 
ATOM   3220 C CZ    . ARG A 1 567 ? 99.951  79.194  103.971 1.00 165.80 ? 541 ARG A CZ    1 
ATOM   3221 N NH1   . ARG A 1 567 ? 100.495 80.389  103.801 1.00 143.50 ? 541 ARG A NH1   1 
ATOM   3222 N NH2   . ARG A 1 567 ? 100.589 78.148  103.468 1.00 175.72 ? 541 ARG A NH2   1 
ATOM   3223 N N     . PHE A 1 568 ? 98.265  83.929  108.921 1.00 56.96  ? 542 PHE A N     1 
ATOM   3224 C CA    . PHE A 1 568 ? 97.959  85.319  108.726 1.00 57.84  ? 542 PHE A CA    1 
ATOM   3225 C C     . PHE A 1 568 ? 99.071  86.240  109.150 1.00 54.78  ? 542 PHE A C     1 
ATOM   3226 O O     . PHE A 1 568 ? 98.937  87.416  108.901 1.00 68.49  ? 542 PHE A O     1 
ATOM   3227 C CB    . PHE A 1 568 ? 96.879  85.735  109.698 1.00 51.84  ? 542 PHE A CB    1 
ATOM   3228 C CG    . PHE A 1 568 ? 96.413  87.167  109.643 1.00 58.47  ? 542 PHE A CG    1 
ATOM   3229 C CD1   . PHE A 1 568 ? 95.587  87.600  108.613 1.00 64.59  ? 542 PHE A CD1   1 
ATOM   3230 C CD2   . PHE A 1 568 ? 96.672  88.036  110.701 1.00 59.50  ? 542 PHE A CD2   1 
ATOM   3231 C CE1   . PHE A 1 568 ? 95.070  88.910  108.627 1.00 81.16  ? 542 PHE A CE1   1 
ATOM   3232 C CE2   . PHE A 1 568 ? 96.133  89.332  110.722 1.00 65.07  ? 542 PHE A CE2   1 
ATOM   3233 C CZ    . PHE A 1 568 ? 95.352  89.797  109.669 1.00 62.96  ? 542 PHE A CZ    1 
ATOM   3234 N N     . CYS A 1 569 ? 100.071 85.774  109.885 1.00 62.57  ? 543 CYS A N     1 
ATOM   3235 C CA    . CYS A 1 569 ? 100.908 86.786  110.489 1.00 68.20  ? 543 CYS A CA    1 
ATOM   3236 C C     . CYS A 1 569 ? 102.402 86.507  110.639 1.00 57.50  ? 543 CYS A C     1 
ATOM   3237 O O     . CYS A 1 569 ? 103.123 87.508  110.635 1.00 74.55  ? 543 CYS A O     1 
ATOM   3238 C CB    . CYS A 1 569 ? 100.351 87.362  111.783 1.00 71.85  ? 543 CYS A CB    1 
ATOM   3239 S SG    . CYS A 1 569 ? 100.828 89.110  111.841 1.00 120.03 ? 543 CYS A SG    1 
ATOM   3240 N N     . LYS A 1 570 ? 102.892 85.266  110.848 1.00 74.00  ? 544 LYS A N     1 
ATOM   3241 C CA    . LYS A 1 570 ? 104.313 85.032  111.164 1.00 95.61  ? 544 LYS A CA    1 
ATOM   3242 C C     . LYS A 1 570 ? 104.783 83.743  110.504 1.00 103.72 ? 544 LYS A C     1 
ATOM   3243 O O     . LYS A 1 570 ? 104.785 82.681  111.128 1.00 125.44 ? 544 LYS A O     1 
ATOM   3244 C CB    . LYS A 1 570 ? 104.563 84.932  112.678 1.00 115.07 ? 544 LYS A CB    1 
ATOM   3245 C CG    . LYS A 1 570 ? 103.505 84.059  113.368 1.00 134.05 ? 544 LYS A CG    1 
ATOM   3246 C CD    . LYS A 1 570 ? 103.823 83.613  114.786 1.00 126.71 ? 544 LYS A CD    1 
ATOM   3247 C CE    . LYS A 1 570 ? 104.067 84.740  115.705 1.00 116.25 ? 544 LYS A CE    1 
ATOM   3248 N NZ    . LYS A 1 570 ? 103.868 84.310  117.102 1.00 139.20 ? 544 LYS A NZ    1 
ATOM   3249 N N     . GLU A 1 571 ? 105.154 83.841  109.228 1.00 114.73 ? 545 GLU A N     1 
ATOM   3250 C CA    . GLU A 1 571 ? 105.127 82.691  108.339 1.00 121.18 ? 545 GLU A CA    1 
ATOM   3251 C C     . GLU A 1 571 ? 105.039 83.272  106.946 1.00 120.61 ? 545 GLU A C     1 
ATOM   3252 O O     . GLU A 1 571 ? 104.097 84.002  106.640 1.00 155.76 ? 545 GLU A O     1 
ATOM   3253 C CB    . GLU A 1 571 ? 103.901 81.776  108.430 1.00 135.42 ? 545 GLU A CB    1 
ATOM   3254 C CG    . GLU A 1 571 ? 104.164 80.336  108.000 1.00 164.03 ? 545 GLU A CG    1 
ATOM   3255 C CD    . GLU A 1 571 ? 102.934 79.429  108.027 1.00 210.83 ? 545 GLU A CD    1 
ATOM   3256 O OE1   . GLU A 1 571 ? 101.789 79.907  108.205 1.00 177.39 ? 545 GLU A OE1   1 
ATOM   3257 O OE2   . GLU A 1 571 ? 103.130 78.203  107.879 1.00 264.67 ? 545 GLU A OE2   1 
ATOM   3258 N N     . ASN A 1 572 ? 106.046 82.979  106.133 1.00 111.12 ? 546 ASN A N     1 
ATOM   3259 C CA    . ASN A 1 572 ? 106.160 83.611  104.834 1.00 99.73  ? 546 ASN A CA    1 
ATOM   3260 C C     . ASN A 1 572 ? 105.097 83.034  103.899 1.00 110.78 ? 546 ASN A C     1 
ATOM   3261 O O     . ASN A 1 572 ? 104.674 81.880  104.011 1.00 124.79 ? 546 ASN A O     1 
ATOM   3262 C CB    . ASN A 1 572 ? 107.587 83.515  104.315 1.00 109.37 ? 546 ASN A CB    1 
ATOM   3263 C CG    . ASN A 1 572 ? 108.564 84.336  105.131 1.00 141.10 ? 546 ASN A CG    1 
ATOM   3264 O OD1   . ASN A 1 572 ? 108.193 85.285  105.839 1.00 103.97 ? 546 ASN A OD1   1 
ATOM   3265 N ND2   . ASN A 1 572 ? 109.839 83.985  105.036 1.00 183.60 ? 546 ASN A ND2   1 
ATOM   3266 N N     . ILE A 1 573 ? 104.676 83.882  102.966 1.00 122.43 ? 547 ILE A N     1 
ATOM   3267 C CA    . ILE A 1 573 ? 103.707 83.512  101.957 1.00 148.55 ? 547 ILE A CA    1 
ATOM   3268 C C     . ILE A 1 573 ? 104.397 82.540  101.004 1.00 184.44 ? 547 ILE A C     1 
ATOM   3269 O O     . ILE A 1 573 ? 105.618 82.572  100.852 1.00 202.55 ? 547 ILE A O     1 
ATOM   3270 C CB    . ILE A 1 573 ? 103.193 84.768  101.232 1.00 165.19 ? 547 ILE A CB    1 
ATOM   3271 C CG1   . ILE A 1 573 ? 102.844 85.899  102.210 1.00 177.54 ? 547 ILE A CG1   1 
ATOM   3272 C CG2   . ILE A 1 573 ? 102.013 84.435  100.319 1.00 188.31 ? 547 ILE A CG2   1 
ATOM   3273 C CD1   . ILE A 1 573 ? 102.872 87.280  101.580 1.00 186.53 ? 547 ILE A CD1   1 
ATOM   3274 N N     . ASN A 1 574 ? 103.587 81.690  100.368 1.00 210.42 ? 548 ASN A N     1 
ATOM   3275 C CA    . ASN A 1 574 ? 104.030 80.637  99.466  1.00 199.29 ? 548 ASN A CA    1 
ATOM   3276 C C     . ASN A 1 574 ? 105.550 80.641  99.322  1.00 198.48 ? 548 ASN A C     1 
ATOM   3277 O O     . ASN A 1 574 ? 106.199 79.701  99.775  1.00 257.71 ? 548 ASN A O     1 
ATOM   3278 C CB    . ASN A 1 574 ? 103.296 80.721  98.134  1.00 230.85 ? 548 ASN A CB    1 
ATOM   3279 C CG    . ASN A 1 574 ? 101.840 81.089  98.320  1.00 285.72 ? 548 ASN A CG    1 
ATOM   3280 O OD1   . ASN A 1 574 ? 101.393 82.135  97.832  1.00 284.67 ? 548 ASN A OD1   1 
ATOM   3281 N ND2   . ASN A 1 574 ? 101.093 80.266  99.045  1.00 289.83 ? 548 ASN A ND2   1 
ATOM   3282 N N     . ASP A 1 575 ? 106.119 81.694  98.719  1.00 153.61 ? 549 ASP A N     1 
ATOM   3283 C CA    . ASP A 1 575 ? 107.518 81.652  98.317  1.00 148.12 ? 549 ASP A CA    1 
ATOM   3284 C C     . ASP A 1 575 ? 108.288 82.900  98.750  1.00 142.81 ? 549 ASP A C     1 
ATOM   3285 O O     . ASP A 1 575 ? 109.504 82.976  98.539  1.00 153.06 ? 549 ASP A O     1 
ATOM   3286 C CB    . ASP A 1 575 ? 107.615 81.392  96.821  1.00 168.57 ? 549 ASP A CB    1 
ATOM   3287 C CG    . ASP A 1 575 ? 106.775 82.311  95.943  1.00 187.00 ? 549 ASP A CG    1 
ATOM   3288 O OD1   . ASP A 1 575 ? 105.566 82.473  96.239  1.00 150.50 ? 549 ASP A OD1   1 
ATOM   3289 O OD2   . ASP A 1 575 ? 107.336 82.852  94.963  1.00 219.79 ? 549 ASP A OD2   1 
ATOM   3290 N N     . LYS A 1 576 ? 107.601 83.843  99.405  1.00 128.39 ? 550 LYS A N     1 
ATOM   3291 C CA    . LYS A 1 576 ? 108.127 85.192  99.578  1.00 138.46 ? 550 LYS A CA    1 
ATOM   3292 C C     . LYS A 1 576 ? 108.825 85.305  100.919 1.00 141.41 ? 550 LYS A C     1 
ATOM   3293 O O     . LYS A 1 576 ? 108.982 84.312  101.626 1.00 152.90 ? 550 LYS A O     1 
ATOM   3294 C CB    . LYS A 1 576 ? 106.996 86.200  99.398  1.00 117.97 ? 550 LYS A CB    1 
ATOM   3295 C CG    . LYS A 1 576 ? 106.284 85.806  98.115  1.00 127.58 ? 550 LYS A CG    1 
ATOM   3296 C CD    . LYS A 1 576 ? 105.490 86.882  97.397  1.00 139.05 ? 550 LYS A CD    1 
ATOM   3297 C CE    . LYS A 1 576 ? 105.574 86.752  95.920  1.00 150.31 ? 550 LYS A CE    1 
ATOM   3298 N NZ    . LYS A 1 576 ? 105.452 85.363  95.471  1.00 169.57 ? 550 LYS A NZ    1 
ATOM   3299 N N     . ASN A 1 577 ? 109.306 86.502  101.229 1.00 128.28 ? 551 ASN A N     1 
ATOM   3300 C CA    . ASN A 1 577 ? 110.150 86.627  102.399 1.00 161.02 ? 551 ASN A CA    1 
ATOM   3301 C C     . ASN A 1 577 ? 109.420 87.496  103.393 1.00 136.76 ? 551 ASN A C     1 
ATOM   3302 O O     . ASN A 1 577 ? 110.050 88.100  104.265 1.00 135.20 ? 551 ASN A O     1 
ATOM   3303 C CB    . ASN A 1 577 ? 111.551 87.110  102.059 1.00 174.95 ? 551 ASN A CB    1 
ATOM   3304 C CG    . ASN A 1 577 ? 112.152 86.204  101.015 1.00 216.37 ? 551 ASN A CG    1 
ATOM   3305 O OD1   . ASN A 1 577 ? 112.180 84.981  101.203 1.00 210.22 ? 551 ASN A OD1   1 
ATOM   3306 N ND2   . ASN A 1 577 ? 112.578 86.772  99.896  1.00 249.24 ? 551 ASN A ND2   1 
ATOM   3307 N N     . PHE A 1 578 ? 108.094 87.527  103.253 1.00 96.21  ? 552 PHE A N     1 
ATOM   3308 C CA    . PHE A 1 578 ? 107.346 88.286  104.223 1.00 90.64  ? 552 PHE A CA    1 
ATOM   3309 C C     . PHE A 1 578 ? 106.071 87.544  104.578 1.00 82.82  ? 552 PHE A C     1 
ATOM   3310 O O     . PHE A 1 578 ? 105.521 86.782  103.789 1.00 76.45  ? 552 PHE A O     1 
ATOM   3311 C CB    . PHE A 1 578 ? 107.094 89.735  103.775 1.00 100.35 ? 552 PHE A CB    1 
ATOM   3312 C CG    . PHE A 1 578 ? 106.821 89.913  102.296 1.00 96.79  ? 552 PHE A CG    1 
ATOM   3313 C CD1   . PHE A 1 578 ? 107.868 89.967  101.401 1.00 102.57 ? 552 PHE A CD1   1 
ATOM   3314 C CD2   . PHE A 1 578 ? 105.523 90.011  101.818 1.00 111.17 ? 552 PHE A CD2   1 
ATOM   3315 C CE1   . PHE A 1 578 ? 107.630 90.121  100.058 1.00 134.17 ? 552 PHE A CE1   1 
ATOM   3316 C CE2   . PHE A 1 578 ? 105.276 90.191  100.471 1.00 112.43 ? 552 PHE A CE2   1 
ATOM   3317 C CZ    . PHE A 1 578 ? 106.338 90.232  99.594  1.00 152.75 ? 552 PHE A CZ    1 
ATOM   3318 N N     . PRO A 1 579 ? 105.560 87.861  105.780 1.00 72.60  ? 553 PRO A N     1 
ATOM   3319 C CA    . PRO A 1 579 ? 104.188 87.555  106.153 1.00 71.39  ? 553 PRO A CA    1 
ATOM   3320 C C     . PRO A 1 579 ? 103.086 88.352  105.449 1.00 71.61  ? 553 PRO A C     1 
ATOM   3321 O O     . PRO A 1 579 ? 103.113 89.591  105.340 1.00 53.38  ? 553 PRO A O     1 
ATOM   3322 C CB    . PRO A 1 579 ? 104.148 87.946  107.624 1.00 86.06  ? 553 PRO A CB    1 
ATOM   3323 C CG    . PRO A 1 579 ? 105.524 88.372  108.002 1.00 90.25  ? 553 PRO A CG    1 
ATOM   3324 C CD    . PRO A 1 579 ? 106.253 88.714  106.756 1.00 85.09  ? 553 PRO A CD    1 
ATOM   3325 N N     . PHE A 1 580 ? 102.003 87.640  105.180 1.00 62.39  ? 554 PHE A N     1 
ATOM   3326 C CA    . PHE A 1 580 ? 100.846 88.254  104.563 1.00 52.74  ? 554 PHE A CA    1 
ATOM   3327 C C     . PHE A 1 580 ? 100.333 89.516  105.241 1.00 45.09  ? 554 PHE A C     1 
ATOM   3328 O O     . PHE A 1 580 ? 99.684  90.322  104.572 1.00 38.61  ? 554 PHE A O     1 
ATOM   3329 C CB    . PHE A 1 580 ? 99.696  87.261  104.626 1.00 57.13  ? 554 PHE A CB    1 
ATOM   3330 C CG    . PHE A 1 580 ? 98.401  87.800  104.054 1.00 46.07  ? 554 PHE A CG    1 
ATOM   3331 C CD1   . PHE A 1 580 ? 98.149  87.689  102.711 1.00 48.41  ? 554 PHE A CD1   1 
ATOM   3332 C CD2   . PHE A 1 580 ? 97.443  88.390  104.868 1.00 45.09  ? 554 PHE A CD2   1 
ATOM   3333 C CE1   . PHE A 1 580 ? 96.960  88.197  102.202 1.00 66.38  ? 554 PHE A CE1   1 
ATOM   3334 C CE2   . PHE A 1 580 ? 96.266  88.907  104.349 1.00 48.37  ? 554 PHE A CE2   1 
ATOM   3335 C CZ    . PHE A 1 580 ? 95.989  88.797  103.025 1.00 47.27  ? 554 PHE A CZ    1 
ATOM   3336 N N     . TRP A 1 581 ? 100.425 89.648  106.569 1.00 47.92  ? 555 TRP A N     1 
ATOM   3337 C CA    . TRP A 1 581 ? 99.673  90.770  107.150 1.00 57.66  ? 555 TRP A CA    1 
ATOM   3338 C C     . TRP A 1 581 ? 100.558 91.990  107.021 1.00 52.15  ? 555 TRP A C     1 
ATOM   3339 O O     . TRP A 1 581 ? 100.058 93.087  106.820 1.00 60.32  ? 555 TRP A O     1 
ATOM   3340 C CB    . TRP A 1 581 ? 99.134  90.579  108.593 1.00 52.57  ? 555 TRP A CB    1 
ATOM   3341 C CG    . TRP A 1 581 ? 98.870  91.874  109.297 1.00 50.20  ? 555 TRP A CG    1 
ATOM   3342 C CD1   . TRP A 1 581 ? 99.719  92.510  110.137 1.00 61.69  ? 555 TRP A CD1   1 
ATOM   3343 C CD2   . TRP A 1 581 ? 97.778  92.794  109.097 1.00 56.01  ? 555 TRP A CD2   1 
ATOM   3344 N NE1   . TRP A 1 581 ? 99.232  93.749  110.488 1.00 56.95  ? 555 TRP A NE1   1 
ATOM   3345 C CE2   . TRP A 1 581 ? 98.053  93.950  109.865 1.00 45.98  ? 555 TRP A CE2   1 
ATOM   3346 C CE3   . TRP A 1 581 ? 96.605  92.742  108.354 1.00 52.40  ? 555 TRP A CE3   1 
ATOM   3347 C CZ2   . TRP A 1 581 ? 97.207  95.024  109.929 1.00 45.65  ? 555 TRP A CZ2   1 
ATOM   3348 C CZ3   . TRP A 1 581 ? 95.778  93.830  108.384 1.00 54.75  ? 555 TRP A CZ3   1 
ATOM   3349 C CH2   . TRP A 1 581 ? 96.076  94.951  109.152 1.00 57.81  ? 555 TRP A CH2   1 
ATOM   3350 N N     . LEU A 1 582 ? 101.857 91.745  107.054 1.00 52.98  ? 556 LEU A N     1 
ATOM   3351 C CA    . LEU A 1 582 ? 102.782 92.829  106.882 1.00 65.01  ? 556 LEU A CA    1 
ATOM   3352 C C     . LEU A 1 582 ? 102.660 93.388  105.477 1.00 62.14  ? 556 LEU A C     1 
ATOM   3353 O O     . LEU A 1 582 ? 102.747 94.600  105.292 1.00 74.04  ? 556 LEU A O     1 
ATOM   3354 C CB    . LEU A 1 582 ? 104.179 92.350  107.244 1.00 95.24  ? 556 LEU A CB    1 
ATOM   3355 C CG    . LEU A 1 582 ? 104.526 92.661  108.703 1.00 132.55 ? 556 LEU A CG    1 
ATOM   3356 C CD1   . LEU A 1 582 ? 105.060 94.082  108.804 1.00 158.71 ? 556 LEU A CD1   1 
ATOM   3357 C CD2   . LEU A 1 582 ? 103.331 92.481  109.676 1.00 129.85 ? 556 LEU A CD2   1 
ATOM   3358 N N     . TRP A 1 583 ? 102.314 92.534  104.520 1.00 56.53  ? 557 TRP A N     1 
ATOM   3359 C CA    . TRP A 1 583 ? 102.158 92.969  103.139 1.00 50.53  ? 557 TRP A CA    1 
ATOM   3360 C C     . TRP A 1 583 ? 101.022 93.948  102.911 1.00 48.06  ? 557 TRP A C     1 
ATOM   3361 O O     . TRP A 1 583 ? 101.226 95.011  102.360 1.00 51.89  ? 557 TRP A O     1 
ATOM   3362 C CB    . TRP A 1 583 ? 101.890 91.732  102.317 1.00 55.01  ? 557 TRP A CB    1 
ATOM   3363 C CG    . TRP A 1 583 ? 101.752 92.040  100.871 1.00 62.77  ? 557 TRP A CG    1 
ATOM   3364 C CD1   . TRP A 1 583 ? 102.725 92.419  100.019 1.00 74.88  ? 557 TRP A CD1   1 
ATOM   3365 C CD2   . TRP A 1 583 ? 100.579 91.828  100.095 1.00 70.62  ? 557 TRP A CD2   1 
ATOM   3366 N NE1   . TRP A 1 583 ? 102.204 92.561  98.772  1.00 83.15  ? 557 TRP A NE1   1 
ATOM   3367 C CE2   . TRP A 1 583 ? 100.901 92.184  98.792  1.00 68.68  ? 557 TRP A CE2   1 
ATOM   3368 C CE3   . TRP A 1 583 ? 99.305  91.360  100.378 1.00 73.77  ? 557 TRP A CE3   1 
ATOM   3369 C CZ2   . TRP A 1 583 ? 99.971  92.113  97.780  1.00 71.75  ? 557 TRP A CZ2   1 
ATOM   3370 C CZ3   . TRP A 1 583 ? 98.404  91.214  99.361  1.00 65.59  ? 557 TRP A CZ3   1 
ATOM   3371 C CH2   . TRP A 1 583 ? 98.732  91.604  98.086  1.00 75.14  ? 557 TRP A CH2   1 
ATOM   3372 N N     . ILE A 1 584 ? 99.834  93.590  103.383 1.00 50.82  ? 558 ILE A N     1 
ATOM   3373 C CA    . ILE A 1 584 ? 98.712  94.501  103.333 1.00 57.83  ? 558 ILE A CA    1 
ATOM   3374 C C     . ILE A 1 584 ? 98.986  95.769  104.135 1.00 56.42  ? 558 ILE A C     1 
ATOM   3375 O O     . ILE A 1 584 ? 98.558  96.871  103.793 1.00 55.89  ? 558 ILE A O     1 
ATOM   3376 C CB    . ILE A 1 584 ? 97.439  93.820  103.841 1.00 68.31  ? 558 ILE A CB    1 
ATOM   3377 C CG1   . ILE A 1 584 ? 97.244  92.557  103.112 1.00 73.47  ? 558 ILE A CG1   1 
ATOM   3378 C CG2   . ILE A 1 584 ? 96.231  94.760  103.693 1.00 80.05  ? 558 ILE A CG2   1 
ATOM   3379 C CD1   . ILE A 1 584 ? 95.799  92.234  102.787 1.00 96.70  ? 558 ILE A CD1   1 
ATOM   3380 N N     . GLU A 1 585 ? 99.638  95.592  105.261 1.00 68.30  ? 559 GLU A N     1 
ATOM   3381 C CA    . GLU A 1 585 ? 99.809  96.713  106.143 1.00 75.24  ? 559 GLU A CA    1 
ATOM   3382 C C     . GLU A 1 585 ? 100.578 97.749  105.347 1.00 70.60  ? 559 GLU A C     1 
ATOM   3383 O O     . GLU A 1 585 ? 100.095 98.880  105.321 1.00 77.20  ? 559 GLU A O     1 
ATOM   3384 C CB    . GLU A 1 585 ? 100.343 96.171  107.467 1.00 102.62 ? 559 GLU A CB    1 
ATOM   3385 C CG    . GLU A 1 585 ? 99.769  96.902  108.674 1.00 103.36 ? 559 GLU A CG    1 
ATOM   3386 C CD    . GLU A 1 585 ? 100.285 98.329  108.643 1.00 142.47 ? 559 GLU A CD    1 
ATOM   3387 O OE1   . GLU A 1 585 ? 101.138 98.626  107.762 1.00 122.91 ? 559 GLU A OE1   1 
ATOM   3388 O OE2   . GLU A 1 585 ? 99.868  99.133  109.513 1.00 208.95 ? 559 GLU A OE2   1 
ATOM   3389 N N     . SER A 1 586 ? 101.621 97.356  104.576 1.00 50.88  ? 560 SER A N     1 
ATOM   3390 C CA    . SER A 1 586 ? 102.306 98.352  103.736 1.00 61.10  ? 560 SER A CA    1 
ATOM   3391 C C     . SER A 1 586 ? 101.449 98.974  102.603 1.00 61.67  ? 560 SER A C     1 
ATOM   3392 O O     . SER A 1 586 ? 101.412 100.195 102.373 1.00 60.62  ? 560 SER A O     1 
ATOM   3393 C CB    . SER A 1 586 ? 103.544 97.844  103.149 1.00 57.43  ? 560 SER A CB    1 
ATOM   3394 O OG    . SER A 1 586 ? 103.260 96.854  102.164 1.00 83.74  ? 560 SER A OG    1 
ATOM   3395 N N     . ILE A 1 587 ? 100.761 98.135  101.846 1.00 49.39  ? 561 ILE A N     1 
ATOM   3396 C CA    . ILE A 1 587 ? 99.922  98.673  100.813 1.00 42.61  ? 561 ILE A CA    1 
ATOM   3397 C C     . ILE A 1 587 ? 98.991  99.672  101.450 1.00 45.55  ? 561 ILE A C     1 
ATOM   3398 O O     . ILE A 1 587 ? 98.449  100.550 100.779 1.00 46.14  ? 561 ILE A O     1 
ATOM   3399 C CB    . ILE A 1 587 ? 99.116  97.564  100.167 1.00 41.45  ? 561 ILE A CB    1 
ATOM   3400 C CG1   . ILE A 1 587 ? 99.999  96.708  99.420  1.00 49.26  ? 561 ILE A CG1   1 
ATOM   3401 C CG2   . ILE A 1 587 ? 97.980  98.059  99.260  1.00 46.23  ? 561 ILE A CG2   1 
ATOM   3402 C CD1   . ILE A 1 587 ? 99.338  95.410  98.935  1.00 68.88  ? 561 ILE A CD1   1 
ATOM   3403 N N     . LEU A 1 588 ? 98.678  99.449  102.712 1.00 52.39  ? 562 LEU A N     1 
ATOM   3404 C CA    . LEU A 1 588 ? 97.617  100.271 103.248 1.00 76.10  ? 562 LEU A CA    1 
ATOM   3405 C C     . LEU A 1 588 ? 98.230  101.633 103.558 1.00 70.90  ? 562 LEU A C     1 
ATOM   3406 O O     . LEU A 1 588 ? 97.553  102.660 103.384 1.00 42.86  ? 562 LEU A O     1 
ATOM   3407 C CB    . LEU A 1 588 ? 96.900  99.637  104.438 1.00 73.60  ? 562 LEU A CB    1 
ATOM   3408 C CG    . LEU A 1 588 ? 95.376  99.720  104.365 1.00 70.23  ? 562 LEU A CG    1 
ATOM   3409 C CD1   . LEU A 1 588 ? 94.836  98.954  105.496 1.00 93.33  ? 562 LEU A CD1   1 
ATOM   3410 C CD2   . LEU A 1 588 ? 94.799  101.103 104.435 1.00 86.83  ? 562 LEU A CD2   1 
ATOM   3411 N N     . GLU A 1 589 ? 99.527  101.600 103.940 1.00 68.06  ? 563 GLU A N     1 
ATOM   3412 C CA    . GLU A 1 589 ? 100.226 102.812 104.336 1.00 77.54  ? 563 GLU A CA    1 
ATOM   3413 C C     . GLU A 1 589 ? 100.501 103.645 103.106 1.00 74.42  ? 563 GLU A C     1 
ATOM   3414 O O     . GLU A 1 589 ? 100.338 104.853 103.171 1.00 86.05  ? 563 GLU A O     1 
ATOM   3415 C CB    . GLU A 1 589 ? 101.601 102.742 104.991 1.00 88.56  ? 563 GLU A CB    1 
ATOM   3416 C CG    . GLU A 1 589 ? 101.761 103.775 106.114 1.00 144.97 ? 563 GLU A CG    1 
ATOM   3417 C CD    . GLU A 1 589 ? 100.916 103.716 107.415 1.00 179.33 ? 563 GLU A CD    1 
ATOM   3418 O OE1   . GLU A 1 589 ? 100.082 102.808 107.729 1.00 131.76 ? 563 GLU A OE1   1 
ATOM   3419 O OE2   . GLU A 1 589 ? 101.135 104.687 108.185 1.00 183.15 ? 563 GLU A OE2   1 
ATOM   3420 N N     . LEU A 1 590 ? 100.818 102.991 101.980 1.00 66.14  ? 564 LEU A N     1 
ATOM   3421 C CA    . LEU A 1 590 ? 100.983 103.702 100.718 1.00 62.06  ? 564 LEU A CA    1 
ATOM   3422 C C     . LEU A 1 590 ? 99.747  104.500 100.228 1.00 49.05  ? 564 LEU A C     1 
ATOM   3423 O O     . LEU A 1 590 ? 99.840  105.599 99.685  1.00 41.12  ? 564 LEU A O     1 
ATOM   3424 C CB    . LEU A 1 590 ? 101.397 102.608 99.749  1.00 59.00  ? 564 LEU A CB    1 
ATOM   3425 C CG    . LEU A 1 590 ? 101.649 103.000 98.283  1.00 51.71  ? 564 LEU A CG    1 
ATOM   3426 C CD1   . LEU A 1 590 ? 102.772 103.986 98.282  1.00 54.62  ? 564 LEU A CD1   1 
ATOM   3427 C CD2   . LEU A 1 590 ? 102.028 101.759 97.394  1.00 46.24  ? 564 LEU A CD2   1 
ATOM   3428 N N     . ILE A 1 591 ? 98.570  103.933 100.390 1.00 46.14  ? 565 ILE A N     1 
ATOM   3429 C CA    . ILE A 1 591 ? 97.384  104.577 99.898  1.00 44.50  ? 565 ILE A CA    1 
ATOM   3430 C C     . ILE A 1 591 ? 97.162  105.808 100.714 1.00 52.97  ? 565 ILE A C     1 
ATOM   3431 O O     . ILE A 1 591 ? 96.580  106.760 100.227 1.00 72.51  ? 565 ILE A O     1 
ATOM   3432 C CB    . ILE A 1 591 ? 96.178  103.651 100.048 1.00 51.26  ? 565 ILE A CB    1 
ATOM   3433 C CG1   . ILE A 1 591 ? 96.382  102.366 99.245  1.00 56.32  ? 565 ILE A CG1   1 
ATOM   3434 C CG2   . ILE A 1 591 ? 94.882  104.400 99.699  1.00 45.94  ? 565 ILE A CG2   1 
ATOM   3435 C CD1   . ILE A 1 591 ? 95.076  101.738 98.823  1.00 64.15  ? 565 ILE A CD1   1 
ATOM   3436 N N     . LYS A 1 592 ? 97.517  105.692 101.991 1.00 80.73  ? 566 LYS A N     1 
ATOM   3437 C CA    . LYS A 1 592 ? 97.115  106.676 102.966 1.00 76.30  ? 566 LYS A CA    1 
ATOM   3438 C C     . LYS A 1 592 ? 97.879  107.934 102.615 1.00 80.65  ? 566 LYS A C     1 
ATOM   3439 O O     . LYS A 1 592 ? 97.269  108.998 102.605 1.00 89.70  ? 566 LYS A O     1 
ATOM   3440 C CB    . LYS A 1 592 ? 97.388  106.182 104.379 1.00 89.04  ? 566 LYS A CB    1 
ATOM   3441 C CG    . LYS A 1 592 ? 96.267  106.492 105.336 1.00 121.56 ? 566 LYS A CG    1 
ATOM   3442 C CD    . LYS A 1 592 ? 96.530  106.097 106.792 1.00 153.58 ? 566 LYS A CD    1 
ATOM   3443 C CE    . LYS A 1 592 ? 97.477  107.042 107.497 1.00 163.23 ? 566 LYS A CE    1 
ATOM   3444 N NZ    . LYS A 1 592 ? 97.378  106.938 108.956 1.00 145.58 ? 566 LYS A NZ    1 
ATOM   3445 N N     . LYS A 1 593 ? 99.143  107.803 102.166 1.00 69.90  ? 567 LYS A N     1 
ATOM   3446 C CA    . LYS A 1 593 ? 99.913  109.017 101.950 1.00 82.68  ? 567 LYS A CA    1 
ATOM   3447 C C     . LYS A 1 593 ? 100.328 109.300 100.508 1.00 85.22  ? 567 LYS A C     1 
ATOM   3448 O O     . LYS A 1 593 ? 101.095 110.230 100.273 1.00 114.56 ? 567 LYS A O     1 
ATOM   3449 C CB    . LYS A 1 593 ? 101.134 109.067 102.858 1.00 93.67  ? 567 LYS A CB    1 
ATOM   3450 C CG    . LYS A 1 593 ? 102.059 107.896 102.740 1.00 122.46 ? 567 LYS A CG    1 
ATOM   3451 C CD    . LYS A 1 593 ? 103.294 108.046 103.623 1.00 165.56 ? 567 LYS A CD    1 
ATOM   3452 C CE    . LYS A 1 593 ? 103.076 108.779 104.941 1.00 188.48 ? 567 LYS A CE    1 
ATOM   3453 N NZ    . LYS A 1 593 ? 102.106 108.196 105.880 1.00 178.14 ? 567 LYS A NZ    1 
ATOM   3454 N N     . HIS A 1 594 ? 99.778  108.610 99.524  1.00 70.14  ? 568 HIS A N     1 
ATOM   3455 C CA    . HIS A 1 594 ? 100.111 108.980 98.170  1.00 58.28  ? 568 HIS A CA    1 
ATOM   3456 C C     . HIS A 1 594 ? 99.034  108.601 97.140  1.00 70.08  ? 568 HIS A C     1 
ATOM   3457 O O     . HIS A 1 594 ? 99.255  108.752 95.926  1.00 69.50  ? 568 HIS A O     1 
ATOM   3458 C CB    . HIS A 1 594 ? 101.349 108.190 97.778  1.00 65.72  ? 568 HIS A CB    1 
ATOM   3459 C CG    . HIS A 1 594 ? 102.583 108.508 98.504  1.00 74.11  ? 568 HIS A CG    1 
ATOM   3460 N ND1   . HIS A 1 594 ? 103.097 109.775 98.555  1.00 68.38  ? 568 HIS A ND1   1 
ATOM   3461 C CD2   . HIS A 1 594 ? 103.454 107.703 99.147  1.00 86.69  ? 568 HIS A CD2   1 
ATOM   3462 C CE1   . HIS A 1 594 ? 104.217 109.721 99.283  1.00 77.94  ? 568 HIS A CE1   1 
ATOM   3463 N NE2   . HIS A 1 594 ? 104.463 108.484 99.631  1.00 78.65  ? 568 HIS A NE2   1 
ATOM   3464 N N     . LEU A 1 595 ? 97.883  108.064 97.564  1.00 54.22  ? 569 LEU A N     1 
ATOM   3465 C CA    . LEU A 1 595 ? 96.963  107.553 96.564  1.00 55.92  ? 569 LEU A CA    1 
ATOM   3466 C C     . LEU A 1 595 ? 95.509  107.786 96.973  1.00 54.64  ? 569 LEU A C     1 
ATOM   3467 O O     . LEU A 1 595 ? 94.621  107.213 96.349  1.00 49.98  ? 569 LEU A O     1 
ATOM   3468 C CB    . LEU A 1 595 ? 97.204  106.083 96.208  1.00 47.37  ? 569 LEU A CB    1 
ATOM   3469 C CG    . LEU A 1 595 ? 98.626  105.728 95.809  1.00 57.19  ? 569 LEU A CG    1 
ATOM   3470 C CD1   . LEU A 1 595 ? 98.949  104.242 95.944  1.00 70.68  ? 569 LEU A CD1   1 
ATOM   3471 C CD2   . LEU A 1 595 ? 98.810  106.178 94.407  1.00 60.95  ? 569 LEU A CD2   1 
ATOM   3472 N N     . LEU A 1 596 ? 95.221  108.643 97.953  1.00 62.59  ? 570 LEU A N     1 
ATOM   3473 C CA    . LEU A 1 596 ? 93.862  108.629 98.493  1.00 73.59  ? 570 LEU A CA    1 
ATOM   3474 C C     . LEU A 1 596 ? 92.846  108.878 97.406  1.00 85.97  ? 570 LEU A C     1 
ATOM   3475 O O     . LEU A 1 596 ? 91.948  108.038 97.244  1.00 69.99  ? 570 LEU A O     1 
ATOM   3476 C CB    . LEU A 1 596 ? 93.553  109.571 99.642  1.00 75.17  ? 570 LEU A CB    1 
ATOM   3477 C CG    . LEU A 1 596 ? 93.804  108.883 100.979 1.00 92.12  ? 570 LEU A CG    1 
ATOM   3478 C CD1   . LEU A 1 596 ? 93.404  109.843 102.054 1.00 123.90 ? 570 LEU A CD1   1 
ATOM   3479 C CD2   . LEU A 1 596 ? 93.070  107.554 101.092 1.00 85.42  ? 570 LEU A CD2   1 
ATOM   3480 N N     . PRO A 1 597 ? 93.039  109.987 96.642  1.00 91.12  ? 571 PRO A N     1 
ATOM   3481 C CA    . PRO A 1 597 ? 92.098  110.479 95.628  1.00 86.76  ? 571 PRO A CA    1 
ATOM   3482 C C     . PRO A 1 597 ? 91.828  109.452 94.542  1.00 69.18  ? 571 PRO A C     1 
ATOM   3483 O O     . PRO A 1 597 ? 90.680  109.145 94.293  1.00 76.60  ? 571 PRO A O     1 
ATOM   3484 C CB    . PRO A 1 597 ? 92.817  111.657 95.060  1.00 107.59 ? 571 PRO A CB    1 
ATOM   3485 C CG    . PRO A 1 597 ? 93.693  112.076 96.185  1.00 109.14 ? 571 PRO A CG    1 
ATOM   3486 C CD    . PRO A 1 597 ? 94.267  110.777 96.649  1.00 82.45  ? 571 PRO A CD    1 
ATOM   3487 N N     . LEU A 1 598 ? 92.881  108.846 93.999  1.00 65.21  ? 572 LEU A N     1 
ATOM   3488 C CA    . LEU A 1 598 ? 92.706  107.760 93.051  1.00 69.32  ? 572 LEU A CA    1 
ATOM   3489 C C     . LEU A 1 598 ? 92.075  106.556 93.711  1.00 64.17  ? 572 LEU A C     1 
ATOM   3490 O O     . LEU A 1 598 ? 91.665  105.659 92.990  1.00 84.92  ? 572 LEU A O     1 
ATOM   3491 C CB    . LEU A 1 598 ? 93.976  107.206 92.418  1.00 79.90  ? 572 LEU A CB    1 
ATOM   3492 C CG    . LEU A 1 598 ? 94.740  108.174 91.531  1.00 86.70  ? 572 LEU A CG    1 
ATOM   3493 C CD1   . LEU A 1 598 ? 95.468  109.174 92.448  1.00 98.88  ? 572 LEU A CD1   1 
ATOM   3494 C CD2   . LEU A 1 598 ? 95.639  107.316 90.656  1.00 79.46  ? 572 LEU A CD2   1 
ATOM   3495 N N     . TRP A 1 599 ? 92.189  106.404 95.029  1.00 71.52  ? 573 TRP A N     1 
ATOM   3496 C CA    . TRP A 1 599 ? 91.676  105.179 95.623  1.00 71.86  ? 573 TRP A CA    1 
ATOM   3497 C C     . TRP A 1 599 ? 90.211  105.406 95.905  1.00 64.78  ? 573 TRP A C     1 
ATOM   3498 O O     . TRP A 1 599 ? 89.379  104.534 95.612  1.00 60.55  ? 573 TRP A O     1 
ATOM   3499 C CB    . TRP A 1 599 ? 92.398  104.765 96.909  1.00 82.09  ? 573 TRP A CB    1 
ATOM   3500 C CG    . TRP A 1 599 ? 91.753  103.591 97.604  1.00 79.40  ? 573 TRP A CG    1 
ATOM   3501 C CD1   . TRP A 1 599 ? 90.826  103.674 98.606  1.00 69.60  ? 573 TRP A CD1   1 
ATOM   3502 C CD2   . TRP A 1 599 ? 91.944  102.187 97.320  1.00 56.58  ? 573 TRP A CD2   1 
ATOM   3503 N NE1   . TRP A 1 599 ? 90.423  102.417 98.941  1.00 67.83  ? 573 TRP A NE1   1 
ATOM   3504 C CE2   . TRP A 1 599 ? 91.076  101.494 98.170  1.00 51.99  ? 573 TRP A CE2   1 
ATOM   3505 C CE3   . TRP A 1 599 ? 92.735  101.453 96.430  1.00 64.41  ? 573 TRP A CE3   1 
ATOM   3506 C CZ2   . TRP A 1 599 ? 90.981  100.113 98.155  1.00 50.98  ? 573 TRP A CZ2   1 
ATOM   3507 C CZ3   . TRP A 1 599 ? 92.664  100.075 96.412  1.00 59.34  ? 573 TRP A CZ3   1 
ATOM   3508 C CH2   . TRP A 1 599 ? 91.779  99.419  97.267  1.00 64.01  ? 573 TRP A CH2   1 
ATOM   3509 N N     . ASN A 1 600 ? 89.929  106.597 96.431  1.00 49.03  ? 574 ASN A N     1 
ATOM   3510 C CA    . ASN A 1 600 ? 88.552  106.911 96.725  1.00 54.46  ? 574 ASN A CA    1 
ATOM   3511 C C     . ASN A 1 600 ? 87.736  106.713 95.463  1.00 72.70  ? 574 ASN A C     1 
ATOM   3512 O O     . ASN A 1 600 ? 86.654  106.120 95.516  1.00 97.72  ? 574 ASN A O     1 
ATOM   3513 C CB    . ASN A 1 600 ? 88.402  108.250 97.434  1.00 65.54  ? 574 ASN A CB    1 
ATOM   3514 C CG    . ASN A 1 600 ? 88.910  108.165 98.869  1.00 75.57  ? 574 ASN A CG    1 
ATOM   3515 O OD1   . ASN A 1 600 ? 88.718  107.154 99.562  1.00 80.81  ? 574 ASN A OD1   1 
ATOM   3516 N ND2   . ASN A 1 600 ? 89.586  109.197 99.353  1.00 85.58  ? 574 ASN A ND2   1 
ATOM   3517 N N     . ASP A 1 601 ? 88.304  107.116 94.319  1.00 86.85  ? 575 ASP A N     1 
ATOM   3518 C CA    . ASP A 1 601 ? 87.541  107.252 93.084  1.00 89.51  ? 575 ASP A CA    1 
ATOM   3519 C C     . ASP A 1 601 ? 87.612  106.001 92.206  1.00 66.04  ? 575 ASP A C     1 
ATOM   3520 O O     . ASP A 1 601 ? 87.092  105.987 91.102  1.00 84.06  ? 575 ASP A O     1 
ATOM   3521 C CB    . ASP A 1 601 ? 87.888  108.572 92.414  1.00 102.03 ? 575 ASP A CB    1 
ATOM   3522 C CG    . ASP A 1 601 ? 87.807  109.781 93.348  1.00 135.13 ? 575 ASP A CG    1 
ATOM   3523 O OD1   . ASP A 1 601 ? 87.818  109.572 94.600  1.00 104.18 ? 575 ASP A OD1   1 
ATOM   3524 O OD2   . ASP A 1 601 ? 87.725  110.926 92.827  1.00 160.61 ? 575 ASP A OD2   1 
ATOM   3525 N N     . GLY A 1 602 ? 88.164  104.912 92.716  1.00 82.39  ? 576 GLY A N     1 
ATOM   3526 C CA    . GLY A 1 602 ? 87.999  103.616 92.073  1.00 98.20  ? 576 GLY A CA    1 
ATOM   3527 C C     . GLY A 1 602 ? 88.850  103.444 90.815  1.00 88.57  ? 576 GLY A C     1 
ATOM   3528 O O     . GLY A 1 602 ? 88.579  102.563 89.998  1.00 93.02  ? 576 GLY A O     1 
ATOM   3529 N N     . CYS A 1 603 ? 89.902  104.258 90.703  1.00 76.93  ? 577 CYS A N     1 
ATOM   3530 C CA    . CYS A 1 603 ? 90.816  104.199 89.578  1.00 65.98  ? 577 CYS A CA    1 
ATOM   3531 C C     . CYS A 1 603 ? 91.693  102.962 89.644  1.00 75.49  ? 577 CYS A C     1 
ATOM   3532 O O     . CYS A 1 603 ? 92.167  102.525 88.585  1.00 74.40  ? 577 CYS A O     1 
ATOM   3533 C CB    . CYS A 1 603 ? 91.622  105.476 89.509  1.00 64.63  ? 577 CYS A CB    1 
ATOM   3534 S SG    . CYS A 1 603 ? 90.496  106.905 89.527  1.00 116.90 ? 577 CYS A SG    1 
ATOM   3535 N N     . ILE A 1 604 ? 91.844  102.387 90.865  1.00 69.64  ? 578 ILE A N     1 
ATOM   3536 C CA    . ILE A 1 604 ? 92.806  101.311 91.114  1.00 65.99  ? 578 ILE A CA    1 
ATOM   3537 C C     . ILE A 1 604 ? 92.083  99.973  91.252  1.00 57.14  ? 578 ILE A C     1 
ATOM   3538 O O     . ILE A 1 604 ? 91.202  99.855  92.084  1.00 101.43 ? 578 ILE A O     1 
ATOM   3539 C CB    . ILE A 1 604 ? 93.639  101.603 92.381  1.00 64.29  ? 578 ILE A CB    1 
ATOM   3540 C CG1   . ILE A 1 604 ? 94.110  103.052 92.508  1.00 72.55  ? 578 ILE A CG1   1 
ATOM   3541 C CG2   . ILE A 1 604 ? 94.807  100.638 92.515  1.00 57.95  ? 578 ILE A CG2   1 
ATOM   3542 C CD1   . ILE A 1 604 ? 95.408  103.213 93.295  1.00 67.00  ? 578 ILE A CD1   1 
ATOM   3543 N N     . MET A 1 605 ? 92.442  98.965  90.470  1.00 55.58  ? 579 MET A N     1 
ATOM   3544 C CA    . MET A 1 605 ? 92.045  97.585  90.756  1.00 70.45  ? 579 MET A CA    1 
ATOM   3545 C C     . MET A 1 605 ? 92.736  97.045  92.015  1.00 75.01  ? 579 MET A C     1 
ATOM   3546 O O     . MET A 1 605 ? 92.254  96.103  92.641  1.00 97.36  ? 579 MET A O     1 
ATOM   3547 C CB    . MET A 1 605 ? 92.462  96.582  89.658  1.00 75.14  ? 579 MET A CB    1 
ATOM   3548 C CG    . MET A 1 605 ? 91.414  96.328  88.609  1.00 90.88  ? 579 MET A CG    1 
ATOM   3549 S SD    . MET A 1 605 ? 91.755  94.806  87.685  1.00 108.87 ? 579 MET A SD    1 
ATOM   3550 C CE    . MET A 1 605 ? 90.353  95.075  86.574  1.00 110.81 ? 579 MET A CE    1 
ATOM   3551 N N     . GLY A 1 606 ? 93.961  97.503  92.255  1.00 75.78  ? 580 GLY A N     1 
ATOM   3552 C CA    . GLY A 1 606 ? 94.798  97.040  93.348  1.00 93.39  ? 580 GLY A CA    1 
ATOM   3553 C C     . GLY A 1 606 ? 95.244  95.568  93.305  1.00 93.49  ? 580 GLY A C     1 
ATOM   3554 O O     . GLY A 1 606 ? 96.437  95.294  93.193  1.00 87.18  ? 580 GLY A O     1 
ATOM   3555 N N     . PHE A 1 607 ? 94.315  94.629  93.549  1.00 84.59  ? 581 PHE A N     1 
ATOM   3556 C CA    . PHE A 1 607 ? 94.668  93.251  93.863  1.00 74.75  ? 581 PHE A CA    1 
ATOM   3557 C C     . PHE A 1 607 ? 94.097  92.374  92.767  1.00 66.92  ? 581 PHE A C     1 
ATOM   3558 O O     . PHE A 1 607 ? 92.897  92.300  92.576  1.00 94.63  ? 581 PHE A O     1 
ATOM   3559 C CB    . PHE A 1 607 ? 94.067  92.743  95.177  1.00 69.67  ? 581 PHE A CB    1 
ATOM   3560 C CG    . PHE A 1 607 ? 94.364  93.646  96.352  1.00 57.94  ? 581 PHE A CG    1 
ATOM   3561 C CD1   . PHE A 1 607 ? 93.509  94.723  96.612  1.00 53.91  ? 581 PHE A CD1   1 
ATOM   3562 C CD2   . PHE A 1 607 ? 95.499  93.437  97.132  1.00 45.72  ? 581 PHE A CD2   1 
ATOM   3563 C CE1   . PHE A 1 607 ? 93.818  95.632  97.622  1.00 64.50  ? 581 PHE A CE1   1 
ATOM   3564 C CE2   . PHE A 1 607 ? 95.804  94.337  98.140  1.00 67.45  ? 581 PHE A CE2   1 
ATOM   3565 C CZ    . PHE A 1 607 ? 94.970  95.442  98.381  1.00 74.07  ? 581 PHE A CZ    1 
ATOM   3566 N N     . ILE A 1 608 ? 94.973  91.803  91.982  1.00 60.31  ? 582 ILE A N     1 
ATOM   3567 C CA    . ILE A 1 608 ? 94.540  91.046  90.844  1.00 55.63  ? 582 ILE A CA    1 
ATOM   3568 C C     . ILE A 1 608 ? 95.708  90.174  90.373  1.00 56.48  ? 582 ILE A C     1 
ATOM   3569 O O     . ILE A 1 608 ? 96.851  90.607  90.308  1.00 68.36  ? 582 ILE A O     1 
ATOM   3570 C CB    . ILE A 1 608 ? 94.037  91.994  89.755  1.00 55.01  ? 582 ILE A CB    1 
ATOM   3571 C CG1   . ILE A 1 608 ? 93.319  91.262  88.659  1.00 92.15  ? 582 ILE A CG1   1 
ATOM   3572 C CG2   . ILE A 1 608 ? 95.230  92.666  89.183  1.00 59.28  ? 582 ILE A CG2   1 
ATOM   3573 C CD1   . ILE A 1 608 ? 92.050  90.584  89.161  1.00 149.03 ? 582 ILE A CD1   1 
ATOM   3574 N N     . SER A 1 609 ? 95.416  88.920  90.090  1.00 63.47  ? 583 SER A N     1 
ATOM   3575 C CA    . SER A 1 609 ? 96.439  87.932  89.846  1.00 89.07  ? 583 SER A CA    1 
ATOM   3576 C C     . SER A 1 609 ? 97.026  88.211  88.483  1.00 122.22 ? 583 SER A C     1 
ATOM   3577 O O     . SER A 1 609 ? 96.291  88.705  87.620  1.00 122.44 ? 583 SER A O     1 
ATOM   3578 C CB    . SER A 1 609 ? 95.819  86.576  89.890  1.00 131.73 ? 583 SER A CB    1 
ATOM   3579 O OG    . SER A 1 609 ? 94.444  86.641  89.501  1.00 108.96 ? 583 SER A OG    1 
ATOM   3580 N N     . LYS A 1 610 ? 98.322  87.899  88.315  1.00 132.70 ? 584 LYS A N     1 
ATOM   3581 C CA    . LYS A 1 610 ? 99.007  88.143  87.047  1.00 121.12 ? 584 LYS A CA    1 
ATOM   3582 C C     . LYS A 1 610 ? 98.808  86.881  86.230  1.00 97.43  ? 584 LYS A C     1 
ATOM   3583 O O     . LYS A 1 610 ? 99.754  86.182  85.887  1.00 127.08 ? 584 LYS A O     1 
ATOM   3584 C CB    . LYS A 1 610 ? 100.480 88.551  87.178  1.00 123.84 ? 584 LYS A CB    1 
ATOM   3585 C CG    . LYS A 1 610 ? 101.222 87.679  88.178  1.00 155.68 ? 584 LYS A CG    1 
ATOM   3586 C CD    . LYS A 1 610 ? 102.735 87.825  88.227  1.00 156.38 ? 584 LYS A CD    1 
ATOM   3587 C CE    . LYS A 1 610 ? 103.191 89.125  88.803  1.00 170.11 ? 584 LYS A CE    1 
ATOM   3588 N NZ    . LYS A 1 610 ? 104.658 89.215  88.845  1.00 172.28 ? 584 LYS A NZ    1 
ATOM   3589 N N     . GLU A 1 611 ? 97.527  86.601  86.010  1.00 95.95  ? 585 GLU A N     1 
ATOM   3590 C CA    . GLU A 1 611 ? 97.053  85.558  85.126  1.00 101.46 ? 585 GLU A CA    1 
ATOM   3591 C C     . GLU A 1 611 ? 95.619  85.908  84.747  1.00 78.84  ? 585 GLU A C     1 
ATOM   3592 O O     . GLU A 1 611 ? 95.148  85.520  83.688  1.00 128.69 ? 585 GLU A O     1 
ATOM   3593 C CB    . GLU A 1 611 ? 97.193  84.175  85.768  1.00 121.52 ? 585 GLU A CB    1 
ATOM   3594 C CG    . GLU A 1 611 ? 96.587  83.060  84.918  1.00 155.45 ? 585 GLU A CG    1 
ATOM   3595 C CD    . GLU A 1 611 ? 96.144  81.854  85.722  1.00 220.46 ? 585 GLU A CD    1 
ATOM   3596 O OE1   . GLU A 1 611 ? 96.715  80.760  85.519  1.00 260.53 ? 585 GLU A OE1   1 
ATOM   3597 O OE2   . GLU A 1 611 ? 95.213  82.014  86.545  1.00 253.16 ? 585 GLU A OE2   1 
ATOM   3598 N N     . ARG A 1 612 ? 94.906  86.583  85.629  1.00 74.11  ? 586 ARG A N     1 
ATOM   3599 C CA    . ARG A 1 612 ? 93.569  87.012  85.310  1.00 100.24 ? 586 ARG A CA    1 
ATOM   3600 C C     . ARG A 1 612 ? 93.699  88.431  84.801  1.00 109.63 ? 586 ARG A C     1 
ATOM   3601 O O     . ARG A 1 612 ? 92.688  89.075  84.492  1.00 106.47 ? 586 ARG A O     1 
ATOM   3602 C CB    . ARG A 1 612 ? 92.610  86.977  86.505  1.00 128.47 ? 586 ARG A CB    1 
ATOM   3603 C CG    . ARG A 1 612 ? 91.159  87.281  86.138  1.00 153.49 ? 586 ARG A CG    1 
ATOM   3604 C CD    . ARG A 1 612 ? 90.323  87.850  87.267  1.00 147.85 ? 586 ARG A CD    1 
ATOM   3605 N NE    . ARG A 1 612 ? 89.070  88.403  86.747  1.00 142.65 ? 586 ARG A NE    1 
ATOM   3606 C CZ    . ARG A 1 612 ? 88.488  89.542  87.138  1.00 168.44 ? 586 ARG A CZ    1 
ATOM   3607 N NH1   . ARG A 1 612 ? 89.056  90.357  88.016  1.00 126.34 ? 586 ARG A NH1   1 
ATOM   3608 N NH2   . ARG A 1 612 ? 87.299  89.867  86.649  1.00 204.97 ? 586 ARG A NH2   1 
ATOM   3609 N N     . GLU A 1 613 ? 94.948  88.913  84.777  1.00 96.12  ? 587 GLU A N     1 
ATOM   3610 C CA    . GLU A 1 613 ? 95.160  90.318  84.475  1.00 110.05 ? 587 GLU A CA    1 
ATOM   3611 C C     . GLU A 1 613 ? 95.507  90.381  83.001  1.00 108.52 ? 587 GLU A C     1 
ATOM   3612 O O     . GLU A 1 613 ? 95.040  91.300  82.333  1.00 116.21 ? 587 GLU A O     1 
ATOM   3613 C CB    . GLU A 1 613 ? 96.126  90.989  85.445  1.00 107.84 ? 587 GLU A CB    1 
ATOM   3614 C CG    . GLU A 1 613 ? 96.882  92.210  84.917  1.00 109.11 ? 587 GLU A CG    1 
ATOM   3615 C CD    . GLU A 1 613 ? 98.403  92.054  84.622  1.00 154.94 ? 587 GLU A CD    1 
ATOM   3616 O OE1   . GLU A 1 613 ? 98.797  91.310  83.667  1.00 150.18 ? 587 GLU A OE1   1 
ATOM   3617 O OE2   . GLU A 1 613 ? 99.235  92.713  85.325  1.00 111.51 ? 587 GLU A OE2   1 
ATOM   3618 N N     . ARG A 1 614 ? 96.274  89.383  82.525  1.00 85.36  ? 588 ARG A N     1 
ATOM   3619 C CA    . ARG A 1 614 ? 96.346  89.086  81.104  1.00 81.03  ? 588 ARG A CA    1 
ATOM   3620 C C     . ARG A 1 614 ? 94.918  88.766  80.667  1.00 70.53  ? 588 ARG A C     1 
ATOM   3621 O O     . ARG A 1 614 ? 94.351  89.502  79.874  1.00 66.26  ? 588 ARG A O     1 
ATOM   3622 C CB    . ARG A 1 614 ? 97.298  87.958  80.682  1.00 99.42  ? 588 ARG A CB    1 
ATOM   3623 C CG    . ARG A 1 614 ? 98.687  88.164  81.280  1.00 138.58 ? 588 ARG A CG    1 
ATOM   3624 C CD    . ARG A 1 614 ? 99.403  86.839  81.634  1.00 170.48 ? 588 ARG A CD    1 
ATOM   3625 N NE    . ARG A 1 614 ? 100.218 86.284  80.543  1.00 223.01 ? 588 ARG A NE    1 
ATOM   3626 C CZ    . ARG A 1 614 ? 101.396 86.747  80.083  1.00 212.16 ? 588 ARG A CZ    1 
ATOM   3627 N NH1   . ARG A 1 614 ? 102.026 87.728  80.729  1.00 182.48 ? 588 ARG A NH1   1 
ATOM   3628 N NH2   . ARG A 1 614 ? 101.939 86.202  78.987  1.00 147.31 ? 588 ARG A NH2   1 
ATOM   3629 N N     . ALA A 1 615 ? 94.253  87.788  81.282  1.00 74.41  ? 589 ALA A N     1 
ATOM   3630 C CA    . ALA A 1 615 ? 92.974  87.322  80.745  1.00 90.07  ? 589 ALA A CA    1 
ATOM   3631 C C     . ALA A 1 615 ? 91.847  88.383  80.886  1.00 70.67  ? 589 ALA A C     1 
ATOM   3632 O O     . ALA A 1 615 ? 90.659  88.138  80.736  1.00 78.91  ? 589 ALA A O     1 
ATOM   3633 C CB    . ALA A 1 615 ? 92.646  85.932  81.321  1.00 92.02  ? 589 ALA A CB    1 
ATOM   3634 N N     . LEU A 1 616 ? 92.202  89.635  80.981  1.00 60.53  ? 590 LEU A N     1 
ATOM   3635 C CA    . LEU A 1 616 ? 91.207  90.673  80.984  1.00 71.63  ? 590 LEU A CA    1 
ATOM   3636 C C     . LEU A 1 616 ? 91.709  91.864  80.137  1.00 104.72 ? 590 LEU A C     1 
ATOM   3637 O O     . LEU A 1 616 ? 91.031  92.891  79.948  1.00 94.35  ? 590 LEU A O     1 
ATOM   3638 C CB    . LEU A 1 616 ? 91.204  90.858  82.509  1.00 68.61  ? 590 LEU A CB    1 
ATOM   3639 C CG    . LEU A 1 616 ? 90.532  92.127  83.053  1.00 94.31  ? 590 LEU A CG    1 
ATOM   3640 C CD1   . LEU A 1 616 ? 89.018  92.081  83.103  1.00 111.14 ? 590 LEU A CD1   1 
ATOM   3641 C CD2   . LEU A 1 616 ? 91.015  92.484  84.436  1.00 113.41 ? 590 LEU A CD2   1 
ATOM   3642 N N     . LEU A 1 617 ? 92.973  91.731  79.685  1.00 99.02  ? 591 LEU A N     1 
ATOM   3643 C CA    . LEU A 1 617 ? 93.648  92.577  78.708  1.00 77.48  ? 591 LEU A CA    1 
ATOM   3644 C C     . LEU A 1 617 ? 93.930  91.719  77.464  1.00 100.25 ? 591 LEU A C     1 
ATOM   3645 O O     . LEU A 1 617 ? 95.077  91.421  77.106  1.00 84.56  ? 591 LEU A O     1 
ATOM   3646 C CB    . LEU A 1 617 ? 94.974  93.121  79.256  1.00 66.44  ? 591 LEU A CB    1 
ATOM   3647 C CG    . LEU A 1 617 ? 94.912  94.077  80.454  1.00 78.11  ? 591 LEU A CG    1 
ATOM   3648 C CD1   . LEU A 1 617 ? 96.330  94.619  80.612  1.00 74.23  ? 591 LEU A CD1   1 
ATOM   3649 C CD2   . LEU A 1 617 ? 93.896  95.231  80.398  1.00 86.02  ? 591 LEU A CD2   1 
ATOM   3650 N N     . LYS A 1 618 ? 92.859  91.221  76.853  1.00 105.23 ? 592 LYS A N     1 
ATOM   3651 C CA    . LYS A 1 618 ? 92.792  91.050  75.409  1.00 106.02 ? 592 LYS A CA    1 
ATOM   3652 C C     . LYS A 1 618 ? 91.564  91.876  74.995  1.00 138.27 ? 592 LYS A C     1 
ATOM   3653 O O     . LYS A 1 618 ? 90.661  91.504  74.213  1.00 82.80  ? 592 LYS A O     1 
ATOM   3654 C CB    . LYS A 1 618 ? 92.905  89.547  75.241  1.00 94.79  ? 592 LYS A CB    1 
ATOM   3655 C CG    . LYS A 1 618 ? 93.984  88.933  76.104  1.00 89.16  ? 592 LYS A CG    1 
ATOM   3656 C CD    . LYS A 1 618 ? 93.755  87.425  76.198  1.00 135.60 ? 592 LYS A CD    1 
ATOM   3657 C CE    . LYS A 1 618 ? 93.274  86.690  74.926  1.00 158.54 ? 592 LYS A CE    1 
ATOM   3658 N NZ    . LYS A 1 618 ? 94.201  86.539  73.786  1.00 123.25 ? 592 LYS A NZ    1 
ATOM   3659 N N     . ASP A 1 619 ? 91.562  93.046  75.650  1.00 143.11 ? 593 ASP A N     1 
ATOM   3660 C CA    . ASP A 1 619 ? 90.433  93.933  75.663  1.00 132.24 ? 593 ASP A CA    1 
ATOM   3661 C C     . ASP A 1 619 ? 90.555  94.635  74.354  1.00 112.20 ? 593 ASP A C     1 
ATOM   3662 O O     . ASP A 1 619 ? 89.918  94.190  73.406  1.00 136.79 ? 593 ASP A O     1 
ATOM   3663 C CB    . ASP A 1 619 ? 90.449  94.931  76.817  1.00 149.85 ? 593 ASP A CB    1 
ATOM   3664 C CG    . ASP A 1 619 ? 89.276  95.914  76.894  1.00 130.40 ? 593 ASP A CG    1 
ATOM   3665 O OD1   . ASP A 1 619 ? 88.121  95.480  77.108  1.00 137.63 ? 593 ASP A OD1   1 
ATOM   3666 O OD2   . ASP A 1 619 ? 89.518  97.125  76.778  1.00 78.95  ? 593 ASP A OD2   1 
ATOM   3667 N N     . GLN A 1 620 ? 91.417  95.660  74.331  1.00 105.46 ? 594 GLN A N     1 
ATOM   3668 C CA    . GLN A 1 620 ? 91.134  96.757  73.418  1.00 153.43 ? 594 GLN A CA    1 
ATOM   3669 C C     . GLN A 1 620 ? 92.391  97.378  72.837  1.00 114.31 ? 594 GLN A C     1 
ATOM   3670 O O     . GLN A 1 620 ? 93.317  96.676  72.456  1.00 98.42  ? 594 GLN A O     1 
ATOM   3671 C CB    . GLN A 1 620 ? 90.254  97.842  74.059  1.00 190.55 ? 594 GLN A CB    1 
ATOM   3672 C CG    . GLN A 1 620 ? 89.698  98.912  73.105  1.00 154.06 ? 594 GLN A CG    1 
ATOM   3673 C CD    . GLN A 1 620 ? 89.597  100.292 73.728  1.00 145.28 ? 594 GLN A CD    1 
ATOM   3674 O OE1   . GLN A 1 620 ? 89.500  100.473 74.952  1.00 164.75 ? 594 GLN A OE1   1 
ATOM   3675 N NE2   . GLN A 1 620 ? 89.540  101.297 72.877  1.00 139.38 ? 594 GLN A NE2   1 
ATOM   3676 N N     . GLN A 1 621 ? 92.314  98.712  72.740  1.00 113.01 ? 595 GLN A N     1 
ATOM   3677 C CA    . GLN A 1 621 ? 93.171  99.528  71.912  1.00 144.10 ? 595 GLN A CA    1 
ATOM   3678 C C     . GLN A 1 621 ? 94.564  99.430  72.492  1.00 106.02 ? 595 GLN A C     1 
ATOM   3679 O O     . GLN A 1 621 ? 94.798  99.786  73.637  1.00 109.83 ? 595 GLN A O     1 
ATOM   3680 C CB    . GLN A 1 621 ? 92.804  101.014 71.928  1.00 184.67 ? 595 GLN A CB    1 
ATOM   3681 C CG    . GLN A 1 621 ? 91.455  101.357 71.308  1.00 187.13 ? 595 GLN A CG    1 
ATOM   3682 C CD    . GLN A 1 621 ? 91.491  101.670 69.830  1.00 229.69 ? 595 GLN A CD    1 
ATOM   3683 O OE1   . GLN A 1 621 ? 92.165  102.608 69.389  1.00 257.39 ? 595 GLN A OE1   1 
ATOM   3684 N NE2   . GLN A 1 621 ? 90.735  100.906 69.052  1.00 243.39 ? 595 GLN A NE2   1 
ATOM   3685 N N     . PRO A 1 622 ? 95.494  98.822  71.759  1.00 91.90  ? 596 PRO A N     1 
ATOM   3686 C CA    . PRO A 1 622 ? 96.843  98.659  72.290  1.00 117.67 ? 596 PRO A CA    1 
ATOM   3687 C C     . PRO A 1 622 ? 97.465  99.839  73.040  1.00 124.33 ? 596 PRO A C     1 
ATOM   3688 O O     . PRO A 1 622 ? 98.396  100.473 72.547  1.00 177.13 ? 596 PRO A O     1 
ATOM   3689 C CB    . PRO A 1 622 ? 97.487  98.311  70.960  1.00 128.48 ? 596 PRO A CB    1 
ATOM   3690 C CG    . PRO A 1 622 ? 96.500  97.271  70.408  1.00 117.83 ? 596 PRO A CG    1 
ATOM   3691 C CD    . PRO A 1 622 ? 95.223  98.085  70.514  1.00 91.47  ? 596 PRO A CD    1 
ATOM   3692 N N     . GLY A 1 623 ? 97.019  100.023 74.293  1.00 99.49  ? 597 GLY A N     1 
ATOM   3693 C CA    . GLY A 1 623 ? 96.982  101.327 74.947  1.00 106.78 ? 597 GLY A CA    1 
ATOM   3694 C C     . GLY A 1 623 ? 95.953  101.369 76.087  1.00 100.99 ? 597 GLY A C     1 
ATOM   3695 O O     . GLY A 1 623 ? 95.420  102.431 76.428  1.00 62.37  ? 597 GLY A O     1 
ATOM   3696 N N     . THR A 1 624 ? 95.710  100.193 76.683  1.00 89.94  ? 598 THR A N     1 
ATOM   3697 C CA    . THR A 1 624 ? 94.995  100.098 77.935  1.00 84.85  ? 598 THR A CA    1 
ATOM   3698 C C     . THR A 1 624 ? 95.951  99.592  79.012  1.00 95.05  ? 598 THR A C     1 
ATOM   3699 O O     . THR A 1 624 ? 96.854  98.785  78.711  1.00 67.22  ? 598 THR A O     1 
ATOM   3700 C CB    . THR A 1 624 ? 93.820  99.157  77.712  1.00 91.64  ? 598 THR A CB    1 
ATOM   3701 O OG1   . THR A 1 624 ? 94.292  98.285  76.670  1.00 61.01  ? 598 THR A OG1   1 
ATOM   3702 C CG2   . THR A 1 624 ? 92.546  99.960  77.457  1.00 85.10  ? 598 THR A CG2   1 
ATOM   3703 N N     . PHE A 1 625 ? 95.687  100.052 80.254  1.00 78.33  ? 599 PHE A N     1 
ATOM   3704 C CA    . PHE A 1 625 ? 96.513  99.713  81.403  1.00 69.97  ? 599 PHE A CA    1 
ATOM   3705 C C     . PHE A 1 625 ? 95.730  99.751  82.733  1.00 93.82  ? 599 PHE A C     1 
ATOM   3706 O O     . PHE A 1 625 ? 94.905  100.653 82.903  1.00 87.97  ? 599 PHE A O     1 
ATOM   3707 C CB    . PHE A 1 625 ? 97.504  100.833 81.133  1.00 55.07  ? 599 PHE A CB    1 
ATOM   3708 C CG    . PHE A 1 625 ? 96.984  102.209 81.542  1.00 49.35  ? 599 PHE A CG    1 
ATOM   3709 C CD1   . PHE A 1 625 ? 96.472  103.047 80.624  1.00 50.75  ? 599 PHE A CD1   1 
ATOM   3710 C CD2   . PHE A 1 625 ? 97.073  102.705 82.828  1.00 49.09  ? 599 PHE A CD2   1 
ATOM   3711 C CE1   . PHE A 1 625 ? 95.964  104.283 80.986  1.00 63.12  ? 599 PHE A CE1   1 
ATOM   3712 C CE2   . PHE A 1 625 ? 96.602  103.960 83.163  1.00 59.79  ? 599 PHE A CE2   1 
ATOM   3713 C CZ    . PHE A 1 625 ? 95.974  104.722 82.249  1.00 57.80  ? 599 PHE A CZ    1 
ATOM   3714 N N     . LEU A 1 626 ? 95.984  98.788  83.664  1.00 90.86  ? 600 LEU A N     1 
ATOM   3715 C CA    . LEU A 1 626 ? 95.418  98.731  85.022  1.00 66.62  ? 600 LEU A CA    1 
ATOM   3716 C C     . LEU A 1 626 ? 96.380  99.431  85.959  1.00 70.33  ? 600 LEU A C     1 
ATOM   3717 O O     . LEU A 1 626 ? 97.550  99.541  85.600  1.00 74.27  ? 600 LEU A O     1 
ATOM   3718 C CB    . LEU A 1 626 ? 95.375  97.292  85.539  1.00 67.21  ? 600 LEU A CB    1 
ATOM   3719 C CG    . LEU A 1 626 ? 94.654  96.312  84.627  1.00 69.97  ? 600 LEU A CG    1 
ATOM   3720 C CD1   . LEU A 1 626 ? 94.863  94.797  84.739  1.00 68.07  ? 600 LEU A CD1   1 
ATOM   3721 C CD2   . LEU A 1 626 ? 93.254  96.698  84.898  1.00 82.21  ? 600 LEU A CD2   1 
ATOM   3722 N N     . LEU A 1 627 ? 95.947  99.707  87.202  1.00 65.78  ? 601 LEU A N     1 
ATOM   3723 C CA    . LEU A 1 627 ? 96.884  99.839  88.323  1.00 55.54  ? 601 LEU A CA    1 
ATOM   3724 C C     . LEU A 1 627 ? 96.790  98.679  89.334  1.00 51.00  ? 601 LEU A C     1 
ATOM   3725 O O     . LEU A 1 627 ? 95.759  98.469  89.927  1.00 78.98  ? 601 LEU A O     1 
ATOM   3726 C CB    . LEU A 1 627 ? 96.493  101.172 88.919  1.00 58.38  ? 601 LEU A CB    1 
ATOM   3727 C CG    . LEU A 1 627 ? 96.209  102.252 87.864  1.00 66.81  ? 601 LEU A CG    1 
ATOM   3728 C CD1   . LEU A 1 627 ? 96.147  103.634 88.596  1.00 71.10  ? 601 LEU A CD1   1 
ATOM   3729 C CD2   . LEU A 1 627 ? 97.223  102.286 86.691  1.00 49.54  ? 601 LEU A CD2   1 
ATOM   3730 N N     . ARG A 1 628 ? 97.860  97.901  89.531  1.00 60.84  ? 602 ARG A N     1 
ATOM   3731 C CA    . ARG A 1 628 ? 98.011  96.879  90.571  1.00 58.81  ? 602 ARG A CA    1 
ATOM   3732 C C     . ARG A 1 628 ? 98.792  97.334  91.810  1.00 63.80  ? 602 ARG A C     1 
ATOM   3733 O O     . ARG A 1 628 ? 99.326  98.426  91.900  1.00 92.08  ? 602 ARG A O     1 
ATOM   3734 C CB    . ARG A 1 628 ? 98.960  95.791  90.051  1.00 51.11  ? 602 ARG A CB    1 
ATOM   3735 C CG    . ARG A 1 628 ? 98.058  95.054  89.094  1.00 57.30  ? 602 ARG A CG    1 
ATOM   3736 C CD    . ARG A 1 628 ? 98.683  93.784  88.652  1.00 62.38  ? 602 ARG A CD    1 
ATOM   3737 N NE    . ARG A 1 628 ? 99.682  93.252  89.568  1.00 66.15  ? 602 ARG A NE    1 
ATOM   3738 C CZ    . ARG A 1 628 ? 100.912 92.994  89.199  1.00 86.32  ? 602 ARG A CZ    1 
ATOM   3739 N NH1   . ARG A 1 628 ? 101.324 93.124  87.951  1.00 99.20  ? 602 ARG A NH1   1 
ATOM   3740 N NH2   . ARG A 1 628 ? 101.754 92.566  90.095  1.00 103.16 ? 602 ARG A NH2   1 
ATOM   3741 N N     . PHE A 1 629 ? 98.919  96.428  92.752  1.00 55.54  ? 603 PHE A N     1 
ATOM   3742 C CA    . PHE A 1 629 ? 99.869  96.533  93.832  1.00 46.86  ? 603 PHE A CA    1 
ATOM   3743 C C     . PHE A 1 629 ? 100.883 95.403  93.665  1.00 48.97  ? 603 PHE A C     1 
ATOM   3744 O O     . PHE A 1 629 ? 100.560 94.236  93.408  1.00 39.33  ? 603 PHE A O     1 
ATOM   3745 C CB    . PHE A 1 629 ? 99.125  96.451  95.186  1.00 46.00  ? 603 PHE A CB    1 
ATOM   3746 C CG    . PHE A 1 629 ? 98.407  97.729  95.551  1.00 42.83  ? 603 PHE A CG    1 
ATOM   3747 C CD1   . PHE A 1 629 ? 99.097  98.918  95.656  1.00 55.43  ? 603 PHE A CD1   1 
ATOM   3748 C CD2   . PHE A 1 629 ? 97.045  97.788  95.668  1.00 47.42  ? 603 PHE A CD2   1 
ATOM   3749 C CE1   . PHE A 1 629 ? 98.410  100.127 95.901  1.00 83.13  ? 603 PHE A CE1   1 
ATOM   3750 C CE2   . PHE A 1 629 ? 96.354  99.011  95.915  1.00 57.03  ? 603 PHE A CE2   1 
ATOM   3751 C CZ    . PHE A 1 629 ? 97.010  100.186 96.013  1.00 53.06  ? 603 PHE A CZ    1 
ATOM   3752 N N     . SER A 1 630 ? 102.150 95.751  93.869  1.00 67.61  ? 604 SER A N     1 
ATOM   3753 C CA    . SER A 1 630 ? 103.180 94.754  93.692  1.00 69.85  ? 604 SER A CA    1 
ATOM   3754 C C     . SER A 1 630 ? 102.931 93.681  94.730  1.00 69.91  ? 604 SER A C     1 
ATOM   3755 O O     . SER A 1 630 ? 102.563 94.014  95.855  1.00 75.29  ? 604 SER A O     1 
ATOM   3756 C CB    . SER A 1 630 ? 104.552 95.331  93.829  1.00 63.53  ? 604 SER A CB    1 
ATOM   3757 O OG    . SER A 1 630 ? 105.494 94.256  93.856  1.00 63.66  ? 604 SER A OG    1 
ATOM   3758 N N     . GLU A 1 631 ? 103.152 92.433  94.332  1.00 63.62  ? 605 GLU A N     1 
ATOM   3759 C CA    . GLU A 1 631 ? 103.064 91.325  95.250  1.00 67.57  ? 605 GLU A CA    1 
ATOM   3760 C C     . GLU A 1 631 ? 104.425 91.018  95.809  1.00 72.08  ? 605 GLU A C     1 
ATOM   3761 O O     . GLU A 1 631 ? 104.475 90.280  96.780  1.00 113.68 ? 605 GLU A O     1 
ATOM   3762 C CB    . GLU A 1 631 ? 102.533 90.046  94.614  1.00 85.53  ? 605 GLU A CB    1 
ATOM   3763 C CG    . GLU A 1 631 ? 101.008 90.095  94.596  1.00 125.35 ? 605 GLU A CG    1 
ATOM   3764 C CD    . GLU A 1 631 ? 100.258 88.975  93.897  1.00 178.95 ? 605 GLU A CD    1 
ATOM   3765 O OE1   . GLU A 1 631 ? 100.740 87.808  93.907  1.00 184.57 ? 605 GLU A OE1   1 
ATOM   3766 O OE2   . GLU A 1 631 ? 99.148  89.291  93.394  1.00 182.20 ? 605 GLU A OE2   1 
ATOM   3767 N N     . SER A 1 632 ? 105.484 91.580  95.233  1.00 68.90  ? 606 SER A N     1 
ATOM   3768 C CA    . SER A 1 632 ? 106.818 91.143  95.596  1.00 79.94  ? 606 SER A CA    1 
ATOM   3769 C C     . SER A 1 632 ? 107.498 92.120  96.552  1.00 77.19  ? 606 SER A C     1 
ATOM   3770 O O     . SER A 1 632 ? 108.578 91.843  97.085  1.00 68.89  ? 606 SER A O     1 
ATOM   3771 C CB    . SER A 1 632 ? 107.638 90.946  94.364  1.00 110.14 ? 606 SER A CB    1 
ATOM   3772 O OG    . SER A 1 632 ? 108.817 90.204  94.662  1.00 131.74 ? 606 SER A OG    1 
ATOM   3773 N N     . SER A 1 633 ? 106.873 93.277  96.778  1.00 68.20  ? 607 SER A N     1 
ATOM   3774 C CA    . SER A 1 633 ? 107.514 94.268  97.623  1.00 82.39  ? 607 SER A CA    1 
ATOM   3775 C C     . SER A 1 633 ? 107.429 93.908  99.106  1.00 85.74  ? 607 SER A C     1 
ATOM   3776 O O     . SER A 1 633 ? 106.989 92.851  99.527  1.00 81.69  ? 607 SER A O     1 
ATOM   3777 C CB    . SER A 1 633 ? 106.928 95.622  97.410  1.00 78.16  ? 607 SER A CB    1 
ATOM   3778 O OG    . SER A 1 633 ? 106.904 95.902  96.028  1.00 85.49  ? 607 SER A OG    1 
ATOM   3779 N N     . ARG A 1 634 ? 107.953 94.814  99.900  1.00 85.88  ? 608 ARG A N     1 
ATOM   3780 C CA    . ARG A 1 634 ? 107.740 94.781  101.310 1.00 77.50  ? 608 ARG A CA    1 
ATOM   3781 C C     . ARG A 1 634 ? 107.454 96.196  101.753 1.00 94.91  ? 608 ARG A C     1 
ATOM   3782 O O     . ARG A 1 634 ? 107.028 96.405  102.884 1.00 162.07 ? 608 ARG A O     1 
ATOM   3783 C CB    . ARG A 1 634 ? 109.052 94.229  101.845 1.00 98.40  ? 608 ARG A CB    1 
ATOM   3784 C CG    . ARG A 1 634 ? 109.071 92.716  101.721 1.00 113.53 ? 608 ARG A CG    1 
ATOM   3785 C CD    . ARG A 1 634 ? 110.272 92.196  102.500 1.00 176.83 ? 608 ARG A CD    1 
ATOM   3786 N NE    . ARG A 1 634 ? 110.269 92.580  103.920 1.00 192.68 ? 608 ARG A NE    1 
ATOM   3787 C CZ    . ARG A 1 634 ? 111.003 92.035  104.890 1.00 198.13 ? 608 ARG A CZ    1 
ATOM   3788 N NH1   . ARG A 1 634 ? 111.795 90.994  104.655 1.00 179.67 ? 608 ARG A NH1   1 
ATOM   3789 N NH2   . ARG A 1 634 ? 110.900 92.524  106.115 1.00 214.76 ? 608 ARG A NH2   1 
ATOM   3790 N N     . GLU A 1 635 ? 107.733 97.162  100.880 1.00 82.57  ? 609 GLU A N     1 
ATOM   3791 C CA    . GLU A 1 635 ? 107.562 98.553  101.237 1.00 82.52  ? 609 GLU A CA    1 
ATOM   3792 C C     . GLU A 1 635 ? 106.186 98.961  100.749 1.00 77.74  ? 609 GLU A C     1 
ATOM   3793 O O     . GLU A 1 635 ? 105.706 100.043 101.085 1.00 110.21 ? 609 GLU A O     1 
ATOM   3794 C CB    . GLU A 1 635 ? 108.655 99.435  100.643 1.00 112.58 ? 609 GLU A CB    1 
ATOM   3795 C CG    . GLU A 1 635 ? 110.020 98.752  100.583 1.00 181.20 ? 609 GLU A CG    1 
ATOM   3796 C CD    . GLU A 1 635 ? 111.142 99.585  99.977  1.00 261.35 ? 609 GLU A CD    1 
ATOM   3797 O OE1   . GLU A 1 635 ? 111.474 100.653 100.542 1.00 304.76 ? 609 GLU A OE1   1 
ATOM   3798 O OE2   . GLU A 1 635 ? 111.693 99.163  98.933  1.00 299.30 ? 609 GLU A OE2   1 
ATOM   3799 N N     . GLY A 1 636 ? 105.545 98.070  99.992  1.00 60.19  ? 610 GLY A N     1 
ATOM   3800 C CA    . GLY A 1 636 ? 104.290 98.417  99.361  1.00 63.88  ? 610 GLY A CA    1 
ATOM   3801 C C     . GLY A 1 636 ? 104.481 99.423  98.226  1.00 61.57  ? 610 GLY A C     1 
ATOM   3802 O O     . GLY A 1 636 ? 105.000 100.521 98.450  1.00 63.83  ? 610 GLY A O     1 
ATOM   3803 N N     . ALA A 1 637 ? 103.941 99.062  97.045  1.00 69.61  ? 611 ALA A N     1 
ATOM   3804 C CA    . ALA A 1 637 ? 104.387 99.600  95.776  1.00 64.72  ? 611 ALA A CA    1 
ATOM   3805 C C     . ALA A 1 637 ? 103.356 99.364  94.685  1.00 68.69  ? 611 ALA A C     1 
ATOM   3806 O O     . ALA A 1 637 ? 103.042 98.207  94.405  1.00 82.20  ? 611 ALA A O     1 
ATOM   3807 C CB    . ALA A 1 637 ? 105.683 98.914  95.427  1.00 60.30  ? 611 ALA A CB    1 
ATOM   3808 N N     . ILE A 1 638 ? 102.946 100.447 94.015  1.00 54.23  ? 612 ILE A N     1 
ATOM   3809 C CA    . ILE A 1 638 ? 102.029 100.389 92.890  1.00 55.08  ? 612 ILE A CA    1 
ATOM   3810 C C     . ILE A 1 638 ? 102.777 100.152 91.584  1.00 50.04  ? 612 ILE A C     1 
ATOM   3811 O O     . ILE A 1 638 ? 103.964 100.468 91.483  1.00 47.38  ? 612 ILE A O     1 
ATOM   3812 C CB    . ILE A 1 638 ? 101.261 101.717 92.804  1.00 69.78  ? 612 ILE A CB    1 
ATOM   3813 C CG1   . ILE A 1 638 ? 99.948  101.585 92.118  1.00 79.46  ? 612 ILE A CG1   1 
ATOM   3814 C CG2   . ILE A 1 638 ? 102.072 102.752 92.067  1.00 80.76  ? 612 ILE A CG2   1 
ATOM   3815 C CD1   . ILE A 1 638 ? 99.101  102.811 92.334  1.00 92.80  ? 612 ILE A CD1   1 
ATOM   3816 N N     . THR A 1 639 ? 102.043 99.660  90.569  1.00 60.29  ? 613 THR A N     1 
ATOM   3817 C CA    . THR A 1 639 ? 102.589 99.369  89.242  1.00 63.40  ? 613 THR A CA    1 
ATOM   3818 C C     . THR A 1 639 ? 101.581 99.784  88.181  1.00 61.80  ? 613 THR A C     1 
ATOM   3819 O O     . THR A 1 639 ? 100.620 100.457 88.535  1.00 82.88  ? 613 THR A O     1 
ATOM   3820 C CB    . THR A 1 639 ? 103.046 97.917  89.159  1.00 54.43  ? 613 THR A CB    1 
ATOM   3821 O OG1   . THR A 1 639 ? 104.464 98.047  89.146  1.00 45.76  ? 613 THR A OG1   1 
ATOM   3822 C CG2   . THR A 1 639 ? 102.913 97.269  87.816  1.00 72.50  ? 613 THR A CG2   1 
ATOM   3823 N N     . PHE A 1 640 ? 101.885 99.567  86.890  1.00 55.33  ? 614 PHE A N     1 
ATOM   3824 C CA    . PHE A 1 640 ? 100.838 99.550  85.876  1.00 56.13  ? 614 PHE A CA    1 
ATOM   3825 C C     . PHE A 1 640 ? 101.230 98.602  84.738  1.00 55.64  ? 614 PHE A C     1 
ATOM   3826 O O     . PHE A 1 640 ? 102.412 98.417  84.432  1.00 56.92  ? 614 PHE A O     1 
ATOM   3827 C CB    . PHE A 1 640 ? 100.448 100.942 85.369  1.00 47.75  ? 614 PHE A CB    1 
ATOM   3828 C CG    . PHE A 1 640 ? 101.655 101.675 84.813  1.00 59.48  ? 614 PHE A CG    1 
ATOM   3829 C CD1   . PHE A 1 640 ? 102.283 101.239 83.649  1.00 65.61  ? 614 PHE A CD1   1 
ATOM   3830 C CD2   . PHE A 1 640 ? 102.200 102.763 85.479  1.00 67.80  ? 614 PHE A CD2   1 
ATOM   3831 C CE1   . PHE A 1 640 ? 103.369 101.922 83.125  1.00 76.64  ? 614 PHE A CE1   1 
ATOM   3832 C CE2   . PHE A 1 640 ? 103.316 103.419 84.962  1.00 89.77  ? 614 PHE A CE2   1 
ATOM   3833 C CZ    . PHE A 1 640 ? 103.906 102.997 83.785  1.00 81.53  ? 614 PHE A CZ    1 
ATOM   3834 N N     . THR A 1 641 ? 100.186 98.021  84.131  1.00 62.01  ? 615 THR A N     1 
ATOM   3835 C CA    . THR A 1 641 ? 100.327 97.145  82.993  1.00 63.43  ? 615 THR A CA    1 
ATOM   3836 C C     . THR A 1 641 ? 99.422  97.625  81.864  1.00 77.99  ? 615 THR A C     1 
ATOM   3837 O O     . THR A 1 641 ? 98.316  98.130  82.156  1.00 52.37  ? 615 THR A O     1 
ATOM   3838 C CB    . THR A 1 641 ? 99.880  95.763  83.415  1.00 69.22  ? 615 THR A CB    1 
ATOM   3839 O OG1   . THR A 1 641 ? 100.776 95.280  84.421  1.00 52.35  ? 615 THR A OG1   1 
ATOM   3840 C CG2   . THR A 1 641 ? 99.758  94.890  82.175  1.00 75.26  ? 615 THR A CG2   1 
ATOM   3841 N N     . TRP A 1 642 ? 99.920  97.411  80.616  1.00 72.16  ? 616 TRP A N     1 
ATOM   3842 C CA    . TRP A 1 642 ? 99.262  97.793  79.365  1.00 65.98  ? 616 TRP A CA    1 
ATOM   3843 C C     . TRP A 1 642 ? 99.439  96.684  78.291  1.00 68.87  ? 616 TRP A C     1 
ATOM   3844 O O     . TRP A 1 642 ? 100.319 95.817  78.444  1.00 54.19  ? 616 TRP A O     1 
ATOM   3845 C CB    . TRP A 1 642 ? 99.853  99.149  78.941  1.00 64.33  ? 616 TRP A CB    1 
ATOM   3846 C CG    . TRP A 1 642 ? 101.227 99.060  78.310  1.00 87.35  ? 616 TRP A CG    1 
ATOM   3847 C CD1   . TRP A 1 642 ? 101.507 98.728  77.021  1.00 106.39 ? 616 TRP A CD1   1 
ATOM   3848 C CD2   . TRP A 1 642 ? 102.513 99.337  78.884  1.00 98.50  ? 616 TRP A CD2   1 
ATOM   3849 N NE1   . TRP A 1 642 ? 102.848 98.736  76.762  1.00 86.27  ? 616 TRP A NE1   1 
ATOM   3850 C CE2   . TRP A 1 642 ? 103.486 99.130  77.880  1.00 77.68  ? 616 TRP A CE2   1 
ATOM   3851 C CE3   . TRP A 1 642 ? 102.933 99.735  80.143  1.00 100.77 ? 616 TRP A CE3   1 
ATOM   3852 C CZ2   . TRP A 1 642 ? 104.833 99.323  78.071  1.00 91.96  ? 616 TRP A CZ2   1 
ATOM   3853 C CZ3   . TRP A 1 642 ? 104.285 99.923  80.328  1.00 156.25 ? 616 TRP A CZ3   1 
ATOM   3854 C CH2   . TRP A 1 642 ? 105.226 99.729  79.311  1.00 110.03 ? 616 TRP A CH2   1 
ATOM   3855 N N     . VAL A 1 643 ? 98.660  96.742  77.166  1.00 72.11  ? 617 VAL A N     1 
ATOM   3856 C CA    . VAL A 1 643 ? 98.697  95.751  76.058  1.00 78.46  ? 617 VAL A CA    1 
ATOM   3857 C C     . VAL A 1 643 ? 98.968  96.303  74.673  1.00 76.42  ? 617 VAL A C     1 
ATOM   3858 O O     . VAL A 1 643 ? 98.443  97.361  74.325  1.00 69.56  ? 617 VAL A O     1 
ATOM   3859 C CB    . VAL A 1 643 ? 97.321  95.176  75.844  1.00 68.76  ? 617 VAL A CB    1 
ATOM   3860 C CG1   . VAL A 1 643 ? 97.223  93.889  76.653  1.00 79.85  ? 617 VAL A CG1   1 
ATOM   3861 C CG2   . VAL A 1 643 ? 96.328  96.319  76.152  1.00 74.88  ? 617 VAL A CG2   1 
ATOM   3862 N N     . GLU A 1 644 ? 99.712  95.541  73.867  1.00 77.77  ? 618 GLU A N     1 
ATOM   3863 C CA    . GLU A 1 644 ? 100.119 96.072  72.577  1.00 98.63  ? 618 GLU A CA    1 
ATOM   3864 C C     . GLU A 1 644 ? 99.416  95.417  71.379  1.00 126.09 ? 618 GLU A C     1 
ATOM   3865 O O     . GLU A 1 644 ? 98.191  95.244  71.344  1.00 124.19 ? 618 GLU A O     1 
ATOM   3866 C CB    . GLU A 1 644 ? 101.639 96.121  72.548  1.00 90.35  ? 618 GLU A CB    1 
ATOM   3867 C CG    . GLU A 1 644 ? 102.191 97.053  73.623  1.00 105.94 ? 618 GLU A CG    1 
ATOM   3868 C CD    . GLU A 1 644 ? 103.365 97.945  73.236  1.00 176.80 ? 618 GLU A CD    1 
ATOM   3869 O OE1   . GLU A 1 644 ? 103.647 98.046  72.015  1.00 223.47 ? 618 GLU A OE1   1 
ATOM   3870 O OE2   . GLU A 1 644 ? 104.008 98.536  74.144  1.00 181.55 ? 618 GLU A OE2   1 
ATOM   3871 N N     . ARG A 1 645 ? 100.183 95.258  70.303  1.00 113.22 ? 619 ARG A N     1 
ATOM   3872 C CA    . ARG A 1 645 ? 99.822  94.430  69.172  1.00 116.13 ? 619 ARG A CA    1 
ATOM   3873 C C     . ARG A 1 645 ? 101.189 93.970  68.701  1.00 130.54 ? 619 ARG A C     1 
ATOM   3874 O O     . ARG A 1 645 ? 102.120 94.795  68.655  1.00 97.79  ? 619 ARG A O     1 
ATOM   3875 C CB    . ARG A 1 645 ? 98.966  95.189  68.145  1.00 135.53 ? 619 ARG A CB    1 
ATOM   3876 C CG    . ARG A 1 645 ? 98.963  94.576  66.744  1.00 189.74 ? 619 ARG A CG    1 
ATOM   3877 C CD    . ARG A 1 645 ? 98.857  95.582  65.563  1.00 209.33 ? 619 ARG A CD    1 
ATOM   3878 N NE    . ARG A 1 645 ? 99.287  95.101  64.235  1.00 206.76 ? 619 ARG A NE    1 
ATOM   3879 C CZ    . ARG A 1 645 ? 98.670  94.222  63.417  1.00 193.06 ? 619 ARG A CZ    1 
ATOM   3880 N NH1   . ARG A 1 645 ? 97.553  93.618  63.800  1.00 201.76 ? 619 ARG A NH1   1 
ATOM   3881 N NH2   . ARG A 1 645 ? 99.173  93.943  62.214  1.00 145.72 ? 619 ARG A NH2   1 
ATOM   3882 N N     . SER A 1 646 ? 101.324 92.655  68.485  1.00 172.47 ? 620 SER A N     1 
ATOM   3883 C CA    . SER A 1 646 ? 102.636 92.054  68.287  1.00 235.62 ? 620 SER A CA    1 
ATOM   3884 C C     . SER A 1 646 ? 102.895 91.748  66.812  1.00 277.67 ? 620 SER A C     1 
ATOM   3885 O O     . SER A 1 646 ? 104.036 91.463  66.446  1.00 260.19 ? 620 SER A O     1 
ATOM   3886 C CB    . SER A 1 646 ? 102.815 90.829  69.160  1.00 223.67 ? 620 SER A CB    1 
ATOM   3887 O OG    . SER A 1 646 ? 103.158 91.192  70.491  1.00 206.59 ? 620 SER A OG    1 
ATOM   3888 N N     . GLN A 1 647 ? 101.833 91.811  65.987  1.00 287.89 ? 621 GLN A N     1 
ATOM   3889 C CA    . GLN A 1 647 ? 101.905 91.586  64.548  1.00 276.84 ? 621 GLN A CA    1 
ATOM   3890 C C     . GLN A 1 647 ? 101.616 90.114  64.228  1.00 248.18 ? 621 GLN A C     1 
ATOM   3891 O O     . GLN A 1 647 ? 101.245 89.784  63.101  1.00 202.47 ? 621 GLN A O     1 
ATOM   3892 C CB    . GLN A 1 647 ? 103.215 92.124  63.958  1.00 258.97 ? 621 GLN A CB    1 
ATOM   3893 C CG    . GLN A 1 647 ? 103.636 91.460  62.651  1.00 250.30 ? 621 GLN A CG    1 
ATOM   3894 C CD    . GLN A 1 647 ? 104.909 92.031  62.071  1.00 225.51 ? 621 GLN A CD    1 
ATOM   3895 O OE1   . GLN A 1 647 ? 105.544 92.916  62.657  1.00 230.87 ? 621 GLN A OE1   1 
ATOM   3896 N NE2   . GLN A 1 647 ? 105.288 91.524  60.905  1.00 201.29 ? 621 GLN A NE2   1 
ATOM   3897 N N     . ASN A 1 648 ? 101.749 89.237  65.233  1.00 264.57 ? 622 ASN A N     1 
ATOM   3898 C CA    . ASN A 1 648 ? 101.569 87.805  65.040  1.00 278.20 ? 622 ASN A CA    1 
ATOM   3899 C C     . ASN A 1 648 ? 100.076 87.502  64.888  1.00 320.98 ? 622 ASN A C     1 
ATOM   3900 O O     . ASN A 1 648 ? 99.712  86.367  64.583  1.00 339.97 ? 622 ASN A O     1 
ATOM   3901 C CB    . ASN A 1 648 ? 102.311 87.002  66.116  1.00 288.20 ? 622 ASN A CB    1 
ATOM   3902 C CG    . ASN A 1 648 ? 101.530 86.707  67.384  1.00 288.93 ? 622 ASN A CG    1 
ATOM   3903 O OD1   . ASN A 1 648 ? 100.657 85.829  67.398  1.00 271.76 ? 622 ASN A OD1   1 
ATOM   3904 N ND2   . ASN A 1 648 ? 101.881 87.354  68.487  1.00 275.59 ? 622 ASN A ND2   1 
ATOM   3905 N N     . GLY A 1 649 ? 99.226  88.527  65.084  1.00 308.44 ? 623 GLY A N     1 
ATOM   3906 C CA    . GLY A 1 649 ? 97.780  88.392  64.984  1.00 291.24 ? 623 GLY A CA    1 
ATOM   3907 C C     . GLY A 1 649 ? 97.182  87.924  66.309  1.00 307.00 ? 623 GLY A C     1 
ATOM   3908 O O     . GLY A 1 649 ? 96.287  87.079  66.331  1.00 347.43 ? 623 GLY A O     1 
ATOM   3909 N N     . GLY A 1 650 ? 97.693  88.489  67.410  1.00 253.74 ? 624 GLY A N     1 
ATOM   3910 C CA    . GLY A 1 650 ? 97.325  88.064  68.750  1.00 214.28 ? 624 GLY A CA    1 
ATOM   3911 C C     . GLY A 1 650 ? 97.839  89.049  69.796  1.00 192.76 ? 624 GLY A C     1 
ATOM   3912 O O     . GLY A 1 650 ? 98.470  90.056  69.456  1.00 144.67 ? 624 GLY A O     1 
ATOM   3913 N N     . GLU A 1 651 ? 97.561  88.711  71.063  1.00 182.23 ? 625 GLU A N     1 
ATOM   3914 C CA    . GLU A 1 651 ? 97.900  89.517  72.225  1.00 143.07 ? 625 GLU A CA    1 
ATOM   3915 C C     . GLU A 1 651 ? 99.396  89.802  72.244  1.00 166.50 ? 625 GLU A C     1 
ATOM   3916 O O     . GLU A 1 651 ? 100.179 89.091  71.616  1.00 197.77 ? 625 GLU A O     1 
ATOM   3917 C CB    . GLU A 1 651 ? 97.595  88.688  73.472  1.00 181.73 ? 625 GLU A CB    1 
ATOM   3918 C CG    . GLU A 1 651 ? 98.623  87.610  73.847  1.00 189.57 ? 625 GLU A CG    1 
ATOM   3919 C CD    . GLU A 1 651 ? 99.118  86.576  72.833  1.00 224.10 ? 625 GLU A CD    1 
ATOM   3920 O OE1   . GLU A 1 651 ? 99.026  86.737  71.593  1.00 216.79 ? 625 GLU A OE1   1 
ATOM   3921 O OE2   . GLU A 1 651 ? 99.622  85.546  73.327  1.00 254.42 ? 625 GLU A OE2   1 
ATOM   3922 N N     . PRO A 1 652 ? 99.841  90.838  72.986  1.00 170.12 ? 626 PRO A N     1 
ATOM   3923 C CA    . PRO A 1 652 ? 101.267 91.121  73.202  1.00 144.62 ? 626 PRO A CA    1 
ATOM   3924 C C     . PRO A 1 652 ? 101.754 90.217  74.306  1.00 130.12 ? 626 PRO A C     1 
ATOM   3925 O O     . PRO A 1 652 ? 100.976 89.476  74.900  1.00 155.61 ? 626 PRO A O     1 
ATOM   3926 C CB    . PRO A 1 652 ? 101.372 92.573  73.641  1.00 133.84 ? 626 PRO A CB    1 
ATOM   3927 C CG    . PRO A 1 652 ? 99.925  93.023  73.617  1.00 175.24 ? 626 PRO A CG    1 
ATOM   3928 C CD    . PRO A 1 652 ? 98.983  91.826  73.641  1.00 183.72 ? 626 PRO A CD    1 
ATOM   3929 N N     . ASP A 1 653 ? 103.046 90.309  74.591  1.00 196.94 ? 627 ASP A N     1 
ATOM   3930 C CA    . ASP A 1 653 ? 103.538 89.700  75.811  1.00 259.71 ? 627 ASP A CA    1 
ATOM   3931 C C     . ASP A 1 653 ? 102.917 90.489  76.968  1.00 181.18 ? 627 ASP A C     1 
ATOM   3932 O O     . ASP A 1 653 ? 103.024 90.070  78.124  1.00 175.65 ? 627 ASP A O     1 
ATOM   3933 C CB    . ASP A 1 653 ? 105.058 89.546  75.790  1.00 308.56 ? 627 ASP A CB    1 
ATOM   3934 C CG    . ASP A 1 653 ? 105.636 88.345  75.040  1.00 292.24 ? 627 ASP A CG    1 
ATOM   3935 O OD1   . ASP A 1 653 ? 104.854 87.526  74.501  1.00 266.08 ? 627 ASP A OD1   1 
ATOM   3936 O OD2   . ASP A 1 653 ? 106.880 88.230  75.006  1.00 270.10 ? 627 ASP A OD2   1 
ATOM   3937 N N     . PHE A 1 654 ? 102.226 91.597  76.635  1.00 103.32 ? 628 PHE A N     1 
ATOM   3938 C CA    . PHE A 1 654 ? 101.924 92.627  77.606  1.00 87.24  ? 628 PHE A CA    1 
ATOM   3939 C C     . PHE A 1 654 ? 103.171 93.177  78.321  1.00 106.83 ? 628 PHE A C     1 
ATOM   3940 O O     . PHE A 1 654 ? 104.297 92.731  78.111  1.00 135.55 ? 628 PHE A O     1 
ATOM   3941 C CB    . PHE A 1 654 ? 101.167 91.839  78.643  1.00 85.15  ? 628 PHE A CB    1 
ATOM   3942 C CG    . PHE A 1 654 ? 99.931  91.098  78.185  1.00 101.48 ? 628 PHE A CG    1 
ATOM   3943 C CD1   . PHE A 1 654 ? 98.702  91.785  78.168  1.00 97.56  ? 628 PHE A CD1   1 
ATOM   3944 C CD2   . PHE A 1 654 ? 99.983  89.717  77.921  1.00 90.86  ? 628 PHE A CD2   1 
ATOM   3945 C CE1   . PHE A 1 654 ? 97.542  91.123  77.826  1.00 77.56  ? 628 PHE A CE1   1 
ATOM   3946 C CE2   . PHE A 1 654 ? 98.822  89.023  77.586  1.00 82.56  ? 628 PHE A CE2   1 
ATOM   3947 C CZ    . PHE A 1 654 ? 97.606  89.734  77.535  1.00 121.72 ? 628 PHE A CZ    1 
ATOM   3948 N N     . HIS A 1 655 ? 102.988 94.101  79.259  1.00 100.26 ? 629 HIS A N     1 
ATOM   3949 C CA    . HIS A 1 655 ? 104.093 94.941  79.666  1.00 96.37  ? 629 HIS A CA    1 
ATOM   3950 C C     . HIS A 1 655 ? 103.879 95.502  81.067  1.00 87.99  ? 629 HIS A C     1 
ATOM   3951 O O     . HIS A 1 655 ? 102.895 96.234  81.233  1.00 103.21 ? 629 HIS A O     1 
ATOM   3952 C CB    . HIS A 1 655 ? 104.101 96.092  78.648  1.00 96.03  ? 629 HIS A CB    1 
ATOM   3953 C CG    . HIS A 1 655 ? 104.776 95.718  77.353  1.00 125.74 ? 629 HIS A CG    1 
ATOM   3954 N ND1   . HIS A 1 655 ? 105.750 94.729  77.283  1.00 108.54 ? 629 HIS A ND1   1 
ATOM   3955 C CD2   . HIS A 1 655 ? 104.666 96.222  76.094  1.00 107.81 ? 629 HIS A CD2   1 
ATOM   3956 C CE1   . HIS A 1 655 ? 106.192 94.643  76.036  1.00 112.42 ? 629 HIS A CE1   1 
ATOM   3957 N NE2   . HIS A 1 655 ? 105.552 95.536  75.289  1.00 101.54 ? 629 HIS A NE2   1 
ATOM   3958 N N     . ALA A 1 656 ? 104.793 95.286  82.041  1.00 60.52  ? 630 ALA A N     1 
ATOM   3959 C CA    . ALA A 1 656 ? 104.645 96.077  83.277  1.00 59.33  ? 630 ALA A CA    1 
ATOM   3960 C C     . ALA A 1 656 ? 105.918 96.754  83.807  1.00 59.04  ? 630 ALA A C     1 
ATOM   3961 O O     . ALA A 1 656 ? 107.035 96.207  83.744  1.00 60.85  ? 630 ALA A O     1 
ATOM   3962 C CB    . ALA A 1 656 ? 104.005 95.246  84.358  1.00 56.03  ? 630 ALA A CB    1 
ATOM   3963 N N     . VAL A 1 657 ? 105.741 97.930  84.429  1.00 54.09  ? 631 VAL A N     1 
ATOM   3964 C CA    . VAL A 1 657 ? 106.926 98.647  84.899  1.00 66.53  ? 631 VAL A CA    1 
ATOM   3965 C C     . VAL A 1 657 ? 107.258 98.251  86.337  1.00 63.77  ? 631 VAL A C     1 
ATOM   3966 O O     . VAL A 1 657 ? 106.343 98.146  87.165  1.00 57.91  ? 631 VAL A O     1 
ATOM   3967 C CB    . VAL A 1 657 ? 106.729 100.161 84.791  1.00 62.84  ? 631 VAL A CB    1 
ATOM   3968 C CG1   . VAL A 1 657 ? 106.180 100.542 83.464  1.00 78.33  ? 631 VAL A CG1   1 
ATOM   3969 C CG2   . VAL A 1 657 ? 105.708 100.688 85.747  1.00 68.73  ? 631 VAL A CG2   1 
ATOM   3970 N N     . GLU A 1 658 ? 108.558 98.057  86.615  1.00 53.64  ? 632 GLU A N     1 
ATOM   3971 C CA    . GLU A 1 658 ? 109.070 97.952  87.977  1.00 60.47  ? 632 GLU A CA    1 
ATOM   3972 C C     . GLU A 1 658 ? 108.391 98.925  88.942  1.00 63.40  ? 632 GLU A C     1 
ATOM   3973 O O     . GLU A 1 658 ? 108.398 100.144 88.745  1.00 84.49  ? 632 GLU A O     1 
ATOM   3974 C CB    . GLU A 1 658 ? 110.523 98.359  88.161  1.00 75.69  ? 632 GLU A CB    1 
ATOM   3975 C CG    . GLU A 1 658 ? 111.479 97.182  88.148  1.00 102.35 ? 632 GLU A CG    1 
ATOM   3976 C CD    . GLU A 1 658 ? 111.555 96.395  89.447  1.00 144.14 ? 632 GLU A CD    1 
ATOM   3977 O OE1   . GLU A 1 658 ? 110.972 96.863  90.454  1.00 181.15 ? 632 GLU A OE1   1 
ATOM   3978 O OE2   . GLU A 1 658 ? 112.223 95.325  89.460  1.00 152.09 ? 632 GLU A OE2   1 
ATOM   3979 N N     . PRO A 1 659 ? 107.884 98.400  90.073  1.00 63.64  ? 633 PRO A N     1 
ATOM   3980 C CA    . PRO A 1 659 ? 106.926 99.115  90.921  1.00 62.08  ? 633 PRO A CA    1 
ATOM   3981 C C     . PRO A 1 659 ? 107.400 100.361 91.650  1.00 73.70  ? 633 PRO A C     1 
ATOM   3982 O O     . PRO A 1 659 ? 108.441 100.319 92.300  1.00 55.62  ? 633 PRO A O     1 
ATOM   3983 C CB    . PRO A 1 659 ? 106.634 98.031  91.913  1.00 67.94  ? 633 PRO A CB    1 
ATOM   3984 C CG    . PRO A 1 659 ? 106.834 96.756  91.114  1.00 67.86  ? 633 PRO A CG    1 
ATOM   3985 C CD    . PRO A 1 659 ? 108.155 97.027  90.523  1.00 67.14  ? 633 PRO A CD    1 
ATOM   3986 N N     . TYR A 1 660 ? 106.578 101.428 91.541  1.00 76.62  ? 634 TYR A N     1 
ATOM   3987 C CA    . TYR A 1 660 ? 106.845 102.724 92.146  1.00 61.76  ? 634 TYR A CA    1 
ATOM   3988 C C     . TYR A 1 660 ? 106.495 102.703 93.622  1.00 69.00  ? 634 TYR A C     1 
ATOM   3989 O O     . TYR A 1 660 ? 105.339 102.583 94.006  1.00 59.41  ? 634 TYR A O     1 
ATOM   3990 C CB    . TYR A 1 660 ? 106.014 103.886 91.632  1.00 49.66  ? 634 TYR A CB    1 
ATOM   3991 C CG    . TYR A 1 660 ? 106.407 104.147 90.194  1.00 79.60  ? 634 TYR A CG    1 
ATOM   3992 C CD1   . TYR A 1 660 ? 107.667 104.614 89.892  1.00 92.76  ? 634 TYR A CD1   1 
ATOM   3993 C CD2   . TYR A 1 660 ? 105.526 103.956 89.147  1.00 86.11  ? 634 TYR A CD2   1 
ATOM   3994 C CE1   . TYR A 1 660 ? 108.053 104.846 88.589  1.00 93.00  ? 634 TYR A CE1   1 
ATOM   3995 C CE2   . TYR A 1 660 ? 105.894 104.204 87.842  1.00 78.69  ? 634 TYR A CE2   1 
ATOM   3996 C CZ    . TYR A 1 660 ? 107.180 104.578 87.565  1.00 76.23  ? 634 TYR A CZ    1 
ATOM   3997 O OH    . TYR A 1 660 ? 107.539 104.784 86.281  1.00 101.54 ? 634 TYR A OH    1 
ATOM   3998 N N     . THR A 1 661 ? 107.523 102.868 94.444  1.00 74.21  ? 635 THR A N     1 
ATOM   3999 C CA    . THR A 1 661 ? 107.334 102.859 95.870  1.00 67.53  ? 635 THR A CA    1 
ATOM   4000 C C     . THR A 1 661 ? 107.321 104.292 96.362  1.00 68.70  ? 635 THR A C     1 
ATOM   4001 O O     . THR A 1 661 ? 107.022 105.180 95.574  1.00 73.46  ? 635 THR A O     1 
ATOM   4002 C CB    . THR A 1 661 ? 108.406 101.999 96.508  1.00 71.83  ? 635 THR A CB    1 
ATOM   4003 O OG1   . THR A 1 661 ? 107.865 102.162 97.821  1.00 84.59  ? 635 THR A OG1   1 
ATOM   4004 C CG2   . THR A 1 661 ? 109.806 102.518 96.208  1.00 80.76  ? 635 THR A CG2   1 
ATOM   4005 N N     . LYS A 1 662 ? 107.562 104.482 97.671  1.00 85.76  ? 636 LYS A N     1 
ATOM   4006 C CA    . LYS A 1 662 ? 107.402 105.776 98.321  1.00 86.39  ? 636 LYS A CA    1 
ATOM   4007 C C     . LYS A 1 662 ? 108.518 106.715 97.878  1.00 80.77  ? 636 LYS A C     1 
ATOM   4008 O O     . LYS A 1 662 ? 108.277 107.897 97.643  1.00 86.57  ? 636 LYS A O     1 
ATOM   4009 C CB    . LYS A 1 662 ? 107.482 105.668 99.842  1.00 108.56 ? 636 LYS A CB    1 
ATOM   4010 C CG    . LYS A 1 662 ? 106.836 104.432 100.433 1.00 146.67 ? 636 LYS A CG    1 
ATOM   4011 C CD    . LYS A 1 662 ? 106.809 104.489 101.959 1.00 186.18 ? 636 LYS A CD    1 
ATOM   4012 C CE    . LYS A 1 662 ? 108.166 104.450 102.592 1.00 176.70 ? 636 LYS A CE    1 
ATOM   4013 N NZ    . LYS A 1 662 ? 108.064 104.135 104.018 1.00 174.36 ? 636 LYS A NZ    1 
ATOM   4014 N N     . LYS A 1 663 ? 109.722 106.159 97.729  1.00 73.27  ? 637 LYS A N     1 
ATOM   4015 C CA    . LYS A 1 663 ? 110.876 106.927 97.307  1.00 86.05  ? 637 LYS A CA    1 
ATOM   4016 C C     . LYS A 1 663 ? 110.642 107.723 96.006  1.00 90.10  ? 637 LYS A C     1 
ATOM   4017 O O     . LYS A 1 663 ? 111.024 108.885 95.912  1.00 100.69 ? 637 LYS A O     1 
ATOM   4018 C CB    . LYS A 1 663 ? 112.072 105.978 97.213  1.00 111.26 ? 637 LYS A CB    1 
ATOM   4019 C CG    . LYS A 1 663 ? 113.391 106.704 96.967  1.00 152.79 ? 637 LYS A CG    1 
ATOM   4020 C CD    . LYS A 1 663 ? 114.429 105.846 96.258  1.00 202.40 ? 637 LYS A CD    1 
ATOM   4021 C CE    . LYS A 1 663 ? 115.792 106.458 96.224  1.00 227.37 ? 637 LYS A CE    1 
ATOM   4022 N NZ    . LYS A 1 663 ? 116.675 105.725 95.311  1.00 238.04 ? 637 LYS A NZ    1 
ATOM   4023 N N     . GLU A 1 664 ? 110.050 107.134 94.965  1.00 88.59  ? 638 GLU A N     1 
ATOM   4024 C CA    . GLU A 1 664 ? 109.795 107.894 93.748  1.00 72.25  ? 638 GLU A CA    1 
ATOM   4025 C C     . GLU A 1 664 ? 108.631 108.810 94.062  1.00 71.25  ? 638 GLU A C     1 
ATOM   4026 O O     . GLU A 1 664 ? 108.649 109.999 93.762  1.00 69.14  ? 638 GLU A O     1 
ATOM   4027 C CB    . GLU A 1 664 ? 109.428 107.021 92.562  1.00 61.37  ? 638 GLU A CB    1 
ATOM   4028 C CG    . GLU A 1 664 ? 110.405 105.855 92.430  1.00 113.50 ? 638 GLU A CG    1 
ATOM   4029 C CD    . GLU A 1 664 ? 110.517 104.767 93.515  1.00 147.84 ? 638 GLU A CD    1 
ATOM   4030 O OE1   . GLU A 1 664 ? 109.658 104.826 94.427  1.00 147.53 ? 638 GLU A OE1   1 
ATOM   4031 O OE2   . GLU A 1 664 ? 111.434 103.878 93.476  1.00 125.85 ? 638 GLU A OE2   1 
ATOM   4032 N N     . LEU A 1 665 ? 107.673 108.243 94.793  1.00 60.36  ? 639 LEU A N     1 
ATOM   4033 C CA    . LEU A 1 665 ? 106.355 108.823 94.840  1.00 62.05  ? 639 LEU A CA    1 
ATOM   4034 C C     . LEU A 1 665 ? 106.389 110.110 95.632  1.00 69.34  ? 639 LEU A C     1 
ATOM   4035 O O     . LEU A 1 665 ? 105.506 110.980 95.464  1.00 63.22  ? 639 LEU A O     1 
ATOM   4036 C CB    . LEU A 1 665 ? 105.281 107.859 95.322  1.00 63.84  ? 639 LEU A CB    1 
ATOM   4037 C CG    . LEU A 1 665 ? 104.403 107.411 94.151  1.00 64.34  ? 639 LEU A CG    1 
ATOM   4038 C CD1   . LEU A 1 665 ? 105.140 106.462 93.264  1.00 59.72  ? 639 LEU A CD1   1 
ATOM   4039 C CD2   . LEU A 1 665 ? 103.142 106.807 94.658  1.00 72.93  ? 639 LEU A CD2   1 
ATOM   4040 N N     . SER A 1 666 ? 107.442 110.207 96.449  1.00 72.87  ? 640 SER A N     1 
ATOM   4041 C CA    . SER A 1 666 ? 107.611 111.348 97.322  1.00 84.36  ? 640 SER A CA    1 
ATOM   4042 C C     . SER A 1 666 ? 108.049 112.542 96.488  1.00 89.71  ? 640 SER A C     1 
ATOM   4043 O O     . SER A 1 666 ? 107.859 113.689 96.901  1.00 90.53  ? 640 SER A O     1 
ATOM   4044 C CB    . SER A 1 666 ? 108.587 111.034 98.370  1.00 94.96  ? 640 SER A CB    1 
ATOM   4045 O OG    . SER A 1 666 ? 109.879 110.987 97.760  1.00 128.92 ? 640 SER A OG    1 
ATOM   4046 N N     . ALA A 1 667 ? 108.637 112.230 95.323  1.00 80.28  ? 641 ALA A N     1 
ATOM   4047 C CA    . ALA A 1 667 ? 109.349 113.214 94.535  1.00 83.00  ? 641 ALA A CA    1 
ATOM   4048 C C     . ALA A 1 667 ? 108.466 113.764 93.455  1.00 85.68  ? 641 ALA A C     1 
ATOM   4049 O O     . ALA A 1 667 ? 108.562 114.953 93.177  1.00 95.38  ? 641 ALA A O     1 
ATOM   4050 C CB    . ALA A 1 667 ? 110.518 112.591 93.867  1.00 105.17 ? 641 ALA A CB    1 
ATOM   4051 N N     . VAL A 1 668 ? 107.735 112.852 92.795  1.00 79.03  ? 642 VAL A N     1 
ATOM   4052 C CA    . VAL A 1 668 ? 106.706 113.264 91.859  1.00 81.80  ? 642 VAL A CA    1 
ATOM   4053 C C     . VAL A 1 668 ? 105.466 112.413 92.050  1.00 67.76  ? 642 VAL A C     1 
ATOM   4054 O O     . VAL A 1 668 ? 105.623 111.285 92.480  1.00 82.66  ? 642 VAL A O     1 
ATOM   4055 C CB    . VAL A 1 668 ? 107.198 113.225 90.410  1.00 78.08  ? 642 VAL A CB    1 
ATOM   4056 C CG1   . VAL A 1 668 ? 107.593 111.843 89.921  1.00 79.69  ? 642 VAL A CG1   1 
ATOM   4057 C CG2   . VAL A 1 668 ? 106.113 113.848 89.540  1.00 106.17 ? 642 VAL A CG2   1 
ATOM   4058 N N     . THR A 1 669 ? 104.257 112.938 91.769  1.00 64.86  ? 643 THR A N     1 
ATOM   4059 C CA    . THR A 1 669 ? 103.063 112.143 92.045  1.00 67.52  ? 643 THR A CA    1 
ATOM   4060 C C     . THR A 1 669 ? 102.847 111.043 91.000  1.00 80.60  ? 643 THR A C     1 
ATOM   4061 O O     . THR A 1 669 ? 103.399 111.060 89.892  1.00 87.78  ? 643 THR A O     1 
ATOM   4062 C CB    . THR A 1 669 ? 101.748 112.897 92.124  1.00 59.68  ? 643 THR A CB    1 
ATOM   4063 O OG1   . THR A 1 669 ? 101.239 112.549 90.843  1.00 60.47  ? 643 THR A OG1   1 
ATOM   4064 C CG2   . THR A 1 669 ? 101.884 114.353 92.501  1.00 74.89  ? 643 THR A CG2   1 
ATOM   4065 N N     . PHE A 1 670 ? 101.956 110.125 91.391  1.00 72.29  ? 644 PHE A N     1 
ATOM   4066 C CA    . PHE A 1 670 ? 101.666 108.932 90.638  1.00 65.66  ? 644 PHE A CA    1 
ATOM   4067 C C     . PHE A 1 670 ? 100.739 109.261 89.490  1.00 63.37  ? 644 PHE A C     1 
ATOM   4068 O O     . PHE A 1 670 ? 100.804 108.583 88.486  1.00 72.21  ? 644 PHE A O     1 
ATOM   4069 C CB    . PHE A 1 670 ? 100.923 107.861 91.429  1.00 61.64  ? 644 PHE A CB    1 
ATOM   4070 C CG    . PHE A 1 670 ? 100.892 106.559 90.674  1.00 48.60  ? 644 PHE A CG    1 
ATOM   4071 C CD1   . PHE A 1 670 ? 102.071 105.989 90.193  1.00 69.51  ? 644 PHE A CD1   1 
ATOM   4072 C CD2   . PHE A 1 670 ? 99.711  106.009 90.268  1.00 50.28  ? 644 PHE A CD2   1 
ATOM   4073 C CE1   . PHE A 1 670 ? 102.086 104.805 89.412  1.00 64.52  ? 644 PHE A CE1   1 
ATOM   4074 C CE2   . PHE A 1 670 ? 99.726  104.829 89.511  1.00 64.69  ? 644 PHE A CE2   1 
ATOM   4075 C CZ    . PHE A 1 670 ? 100.917 104.197 89.115  1.00 54.02  ? 644 PHE A CZ    1 
ATOM   4076 N N     . PRO A 1 671 ? 99.838  110.256 89.605  1.00 60.56  ? 645 PRO A N     1 
ATOM   4077 C CA    . PRO A 1 671 ? 99.231  110.925 88.436  1.00 62.57  ? 645 PRO A CA    1 
ATOM   4078 C C     . PRO A 1 671 ? 100.214 111.601 87.487  1.00 67.29  ? 645 PRO A C     1 
ATOM   4079 O O     . PRO A 1 671 ? 100.314 111.262 86.299  1.00 81.83  ? 645 PRO A O     1 
ATOM   4080 C CB    . PRO A 1 671 ? 98.312  111.913 89.020  1.00 59.23  ? 645 PRO A CB    1 
ATOM   4081 C CG    . PRO A 1 671 ? 97.947  111.168 90.266  1.00 74.43  ? 645 PRO A CG    1 
ATOM   4082 C CD    . PRO A 1 671 ? 99.257  110.687 90.860  1.00 61.20  ? 645 PRO A CD    1 
ATOM   4083 N N     . ASP A 1 672 ? 101.033 112.487 88.018  1.00 69.44  ? 646 ASP A N     1 
ATOM   4084 C CA    . ASP A 1 672 ? 102.078 113.028 87.172  1.00 80.43  ? 646 ASP A CA    1 
ATOM   4085 C C     . ASP A 1 672 ? 102.915 111.907 86.561  1.00 68.33  ? 646 ASP A C     1 
ATOM   4086 O O     . ASP A 1 672 ? 103.346 112.044 85.430  1.00 62.41  ? 646 ASP A O     1 
ATOM   4087 C CB    . ASP A 1 672 ? 102.868 114.113 87.869  1.00 89.60  ? 646 ASP A CB    1 
ATOM   4088 C CG    . ASP A 1 672 ? 102.031 115.329 88.261  1.00 138.66 ? 646 ASP A CG    1 
ATOM   4089 O OD1   . ASP A 1 672 ? 101.122 115.756 87.475  1.00 117.30 ? 646 ASP A OD1   1 
ATOM   4090 O OD2   . ASP A 1 672 ? 102.306 115.868 89.354  1.00 178.16 ? 646 ASP A OD2   1 
ATOM   4091 N N     . ILE A 1 673 ? 103.148 110.788 87.247  1.00 61.98  ? 647 ILE A N     1 
ATOM   4092 C CA    . ILE A 1 673 ? 103.965 109.823 86.554  1.00 58.05  ? 647 ILE A CA    1 
ATOM   4093 C C     . ILE A 1 673 ? 103.210 109.441 85.321  1.00 58.34  ? 647 ILE A C     1 
ATOM   4094 O O     . ILE A 1 673 ? 103.801 109.413 84.249  1.00 80.37  ? 647 ILE A O     1 
ATOM   4095 C CB    . ILE A 1 673 ? 104.360 108.588 87.354  1.00 66.49  ? 647 ILE A CB    1 
ATOM   4096 C CG1   . ILE A 1 673 ? 105.473 108.926 88.341  1.00 77.29  ? 647 ILE A CG1   1 
ATOM   4097 C CG2   . ILE A 1 673 ? 104.770 107.451 86.404  1.00 54.89  ? 647 ILE A CG2   1 
ATOM   4098 C CD1   . ILE A 1 673 ? 105.983 107.720 89.123  1.00 79.14  ? 647 ILE A CD1   1 
ATOM   4099 N N     . ILE A 1 674 ? 101.922 109.160 85.496  1.00 63.63  ? 648 ILE A N     1 
ATOM   4100 C CA    . ILE A 1 674 ? 101.220 108.436 84.458  1.00 73.71  ? 648 ILE A CA    1 
ATOM   4101 C C     . ILE A 1 674 ? 101.045 109.351 83.269  1.00 82.16  ? 648 ILE A C     1 
ATOM   4102 O O     . ILE A 1 674 ? 101.283 108.911 82.151  1.00 71.81  ? 648 ILE A O     1 
ATOM   4103 C CB    . ILE A 1 674 ? 99.867  107.896 84.887  1.00 70.25  ? 648 ILE A CB    1 
ATOM   4104 C CG1   . ILE A 1 674 ? 100.032 106.784 85.876  1.00 97.13  ? 648 ILE A CG1   1 
ATOM   4105 C CG2   . ILE A 1 674 ? 99.179  107.382 83.652  1.00 76.18  ? 648 ILE A CG2   1 
ATOM   4106 C CD1   . ILE A 1 674 ? 98.739  106.317 86.522  1.00 110.70 ? 648 ILE A CD1   1 
ATOM   4107 N N     . ARG A 1 675 ? 100.680 110.608 83.547  1.00 75.54  ? 649 ARG A N     1 
ATOM   4108 C CA    . ARG A 1 675 ? 100.491 111.609 82.512  1.00 72.86  ? 649 ARG A CA    1 
ATOM   4109 C C     . ARG A 1 675 ? 101.600 111.619 81.466  1.00 79.16  ? 649 ARG A C     1 
ATOM   4110 O O     . ARG A 1 675 ? 101.261 111.778 80.291  1.00 92.59  ? 649 ARG A O     1 
ATOM   4111 C CB    . ARG A 1 675 ? 100.579 112.983 83.144  1.00 59.88  ? 649 ARG A CB    1 
ATOM   4112 C CG    . ARG A 1 675 ? 100.574 114.080 82.105  1.00 60.06  ? 649 ARG A CG    1 
ATOM   4113 C CD    . ARG A 1 675 ? 99.250  114.771 82.343  1.00 78.37  ? 649 ARG A CD    1 
ATOM   4114 N NE    . ARG A 1 675 ? 99.445  116.029 83.048  1.00 81.92  ? 649 ARG A NE    1 
ATOM   4115 C CZ    . ARG A 1 675 ? 99.881  117.073 82.428  1.00 104.42 ? 649 ARG A CZ    1 
ATOM   4116 N NH1   . ARG A 1 675 ? 99.665  117.219 81.123  1.00 91.52  ? 649 ARG A NH1   1 
ATOM   4117 N NH2   . ARG A 1 675 ? 100.485 117.995 83.157  1.00 154.16 ? 649 ARG A NH2   1 
ATOM   4118 N N     . ASN A 1 676 ? 102.874 111.433 81.894  1.00 59.12  ? 650 ASN A N     1 
ATOM   4119 C CA    . ASN A 1 676 ? 104.027 111.801 81.092  1.00 55.69  ? 650 ASN A CA    1 
ATOM   4120 C C     . ASN A 1 676 ? 104.944 110.654 80.788  1.00 63.77  ? 650 ASN A C     1 
ATOM   4121 O O     . ASN A 1 676 ? 105.993 110.914 80.238  1.00 117.61 ? 650 ASN A O     1 
ATOM   4122 C CB    . ASN A 1 676 ? 104.894 112.829 81.781  1.00 57.44  ? 650 ASN A CB    1 
ATOM   4123 C CG    . ASN A 1 676 ? 104.211 114.178 81.748  1.00 94.23  ? 650 ASN A CG    1 
ATOM   4124 O OD1   . ASN A 1 676 ? 103.905 114.658 80.646  1.00 124.68 ? 650 ASN A OD1   1 
ATOM   4125 N ND2   . ASN A 1 676 ? 103.982 114.815 82.898  1.00 96.34  ? 650 ASN A ND2   1 
ATOM   4126 N N     . TYR A 1 677 ? 104.600 109.411 81.121  1.00 76.76  ? 651 TYR A N     1 
ATOM   4127 C CA    . TYR A 1 677 ? 105.553 108.324 80.899  1.00 68.36  ? 651 TYR A CA    1 
ATOM   4128 C C     . TYR A 1 677 ? 105.847 108.280 79.418  1.00 74.50  ? 651 TYR A C     1 
ATOM   4129 O O     . TYR A 1 677 ? 104.976 108.780 78.701  1.00 79.40  ? 651 TYR A O     1 
ATOM   4130 C CB    . TYR A 1 677 ? 104.935 106.997 81.258  1.00 59.40  ? 651 TYR A CB    1 
ATOM   4131 C CG    . TYR A 1 677 ? 105.785 105.766 81.070  1.00 49.45  ? 651 TYR A CG    1 
ATOM   4132 C CD1   . TYR A 1 677 ? 106.796 105.418 81.926  1.00 57.06  ? 651 TYR A CD1   1 
ATOM   4133 C CD2   . TYR A 1 677 ? 105.394 104.814 80.194  1.00 55.75  ? 651 TYR A CD2   1 
ATOM   4134 C CE1   . TYR A 1 677 ? 107.459 104.192 81.841  1.00 57.79  ? 651 TYR A CE1   1 
ATOM   4135 C CE2   . TYR A 1 677 ? 106.115 103.638 80.016  1.00 66.12  ? 651 TYR A CE2   1 
ATOM   4136 C CZ    . TYR A 1 677 ? 107.172 103.301 80.825  1.00 50.31  ? 651 TYR A CZ    1 
ATOM   4137 O OH    . TYR A 1 677 ? 107.750 102.078 80.530  1.00 33.90  ? 651 TYR A OH    1 
ATOM   4138 N N     . LYS A 1 678 ? 107.029 107.765 79.001  1.00 63.39  ? 652 LYS A N     1 
ATOM   4139 C CA    . LYS A 1 678 ? 107.420 107.950 77.613  1.00 53.61  ? 652 LYS A CA    1 
ATOM   4140 C C     . LYS A 1 678 ? 107.816 106.673 76.890  1.00 68.29  ? 652 LYS A C     1 
ATOM   4141 O O     . LYS A 1 678 ? 107.209 106.359 75.856  1.00 69.28  ? 652 LYS A O     1 
ATOM   4142 C CB    . LYS A 1 678 ? 108.611 108.859 77.477  1.00 59.60  ? 652 LYS A CB    1 
ATOM   4143 C CG    . LYS A 1 678 ? 108.260 110.294 77.495  1.00 70.62  ? 652 LYS A CG    1 
ATOM   4144 C CD    . LYS A 1 678 ? 107.429 110.823 76.351  1.00 61.50  ? 652 LYS A CD    1 
ATOM   4145 C CE    . LYS A 1 678 ? 106.720 112.057 76.855  1.00 99.67  ? 652 LYS A CE    1 
ATOM   4146 N NZ    . LYS A 1 678 ? 105.295 111.868 77.210  1.00 107.88 ? 652 LYS A NZ    1 
ATOM   4147 N N     . VAL A 1 679 ? 108.844 105.965 77.393  1.00 74.00  ? 653 VAL A N     1 
ATOM   4148 C CA    . VAL A 1 679 ? 109.507 104.949 76.571  1.00 74.42  ? 653 VAL A CA    1 
ATOM   4149 C C     . VAL A 1 679 ? 110.285 105.574 75.400  1.00 77.33  ? 653 VAL A C     1 
ATOM   4150 O O     . VAL A 1 679 ? 109.731 106.204 74.505  1.00 50.86  ? 653 VAL A O     1 
ATOM   4151 C CB    . VAL A 1 679 ? 108.540 103.949 75.937  1.00 78.11  ? 653 VAL A CB    1 
ATOM   4152 C CG1   . VAL A 1 679 ? 109.304 103.148 74.895  1.00 74.47  ? 653 VAL A CG1   1 
ATOM   4153 C CG2   . VAL A 1 679 ? 107.836 103.073 76.977  1.00 98.44  ? 653 VAL A CG2   1 
ATOM   4154 N N     . MET A 1 680 ? 111.595 105.317 75.383  1.00 100.41 ? 654 MET A N     1 
ATOM   4155 C CA    . MET A 1 680 ? 112.565 106.110 74.645  1.00 90.36  ? 654 MET A CA    1 
ATOM   4156 C C     . MET A 1 680 ? 113.516 105.194 73.912  1.00 99.35  ? 654 MET A C     1 
ATOM   4157 O O     . MET A 1 680 ? 113.445 103.974 74.011  1.00 114.77 ? 654 MET A O     1 
ATOM   4158 C CB    . MET A 1 680 ? 113.389 107.011 75.577  1.00 92.36  ? 654 MET A CB    1 
ATOM   4159 C CG    . MET A 1 680 ? 112.578 108.223 75.976  1.00 101.66 ? 654 MET A CG    1 
ATOM   4160 S SD    . MET A 1 680 ? 113.427 109.637 76.698  1.00 113.87 ? 654 MET A SD    1 
ATOM   4161 C CE    . MET A 1 680 ? 112.038 110.716 76.314  1.00 76.71  ? 654 MET A CE    1 
ATOM   4162 N N     . ALA A 1 681 ? 114.374 105.828 73.134  1.00 146.15 ? 655 ALA A N     1 
ATOM   4163 C CA    . ALA A 1 681 ? 115.245 105.111 72.237  1.00 182.61 ? 655 ALA A CA    1 
ATOM   4164 C C     . ALA A 1 681 ? 116.560 105.874 72.188  1.00 203.45 ? 655 ALA A C     1 
ATOM   4165 O O     . ALA A 1 681 ? 116.887 106.609 73.122  1.00 211.97 ? 655 ALA A O     1 
ATOM   4166 C CB    . ALA A 1 681 ? 114.551 104.993 70.890  1.00 195.20 ? 655 ALA A CB    1 
ATOM   4167 N N     . ALA A 1 682 ? 117.316 105.667 71.113  1.00 216.40 ? 656 ALA A N     1 
ATOM   4168 C CA    . ALA A 1 682 ? 118.430 106.536 70.803  1.00 225.19 ? 656 ALA A CA    1 
ATOM   4169 C C     . ALA A 1 682 ? 117.887 107.795 70.119  1.00 179.88 ? 656 ALA A C     1 
ATOM   4170 O O     . ALA A 1 682 ? 117.886 108.884 70.693  1.00 173.05 ? 656 ALA A O     1 
ATOM   4171 C CB    . ALA A 1 682 ? 119.437 105.770 69.961  1.00 236.10 ? 656 ALA A CB    1 
ATOM   4172 N N     . GLU A 1 683 ? 117.375 107.617 68.903  1.00 143.06 ? 657 GLU A N     1 
ATOM   4173 C CA    . GLU A 1 683 ? 117.169 108.724 67.992  1.00 151.37 ? 657 GLU A CA    1 
ATOM   4174 C C     . GLU A 1 683 ? 115.819 108.508 67.338  1.00 161.45 ? 657 GLU A C     1 
ATOM   4175 O O     . GLU A 1 683 ? 115.688 108.609 66.119  1.00 180.61 ? 657 GLU A O     1 
ATOM   4176 C CB    . GLU A 1 683 ? 118.279 108.808 66.938  1.00 160.50 ? 657 GLU A CB    1 
ATOM   4177 N N     . ASN A 1 684 ? 114.835 108.154 68.166  1.00 150.63 ? 658 ASN A N     1 
ATOM   4178 C CA    . ASN A 1 684 ? 113.461 108.121 67.703  1.00 159.68 ? 658 ASN A CA    1 
ATOM   4179 C C     . ASN A 1 684 ? 112.617 109.010 68.607  1.00 132.18 ? 658 ASN A C     1 
ATOM   4180 O O     . ASN A 1 684 ? 112.742 108.960 69.834  1.00 136.01 ? 658 ASN A O     1 
ATOM   4181 C CB    . ASN A 1 684 ? 112.948 106.691 67.637  1.00 167.32 ? 658 ASN A CB    1 
ATOM   4182 C CG    . ASN A 1 684 ? 113.882 105.808 66.847  1.00 192.41 ? 658 ASN A CG    1 
ATOM   4183 O OD1   . ASN A 1 684 ? 115.088 105.806 67.120  1.00 191.39 ? 658 ASN A OD1   1 
ATOM   4184 N ND2   . ASN A 1 684 ? 113.364 105.069 65.871  1.00 198.37 ? 658 ASN A ND2   1 
ATOM   4185 N N     . ILE A 1 685 ? 111.752 109.814 67.997  1.00 91.28  ? 659 ILE A N     1 
ATOM   4186 C CA    . ILE A 1 685 ? 110.693 110.423 68.776  1.00 116.55 ? 659 ILE A CA    1 
ATOM   4187 C C     . ILE A 1 685 ? 110.161 109.428 69.819  1.00 130.12 ? 659 ILE A C     1 
ATOM   4188 O O     . ILE A 1 685 ? 109.853 108.290 69.464  1.00 137.62 ? 659 ILE A O     1 
ATOM   4189 C CB    . ILE A 1 685 ? 109.563 110.897 67.856  1.00 99.82  ? 659 ILE A CB    1 
ATOM   4190 C CG1   . ILE A 1 685 ? 109.961 112.141 67.107  1.00 134.95 ? 659 ILE A CG1   1 
ATOM   4191 C CG2   . ILE A 1 685 ? 108.307 111.152 68.673  1.00 92.50  ? 659 ILE A CG2   1 
ATOM   4192 C CD1   . ILE A 1 685 ? 108.885 112.667 66.175  1.00 155.88 ? 659 ILE A CD1   1 
ATOM   4193 N N     . PRO A 1 686 ? 109.928 109.824 71.098  1.00 106.55 ? 660 PRO A N     1 
ATOM   4194 C CA    . PRO A 1 686 ? 109.479 108.898 72.125  1.00 111.43 ? 660 PRO A CA    1 
ATOM   4195 C C     . PRO A 1 686 ? 107.947 108.867 72.251  1.00 127.33 ? 660 PRO A C     1 
ATOM   4196 O O     . PRO A 1 686 ? 107.267 109.874 71.998  1.00 92.51  ? 660 PRO A O     1 
ATOM   4197 C CB    . PRO A 1 686 ? 110.224 109.547 73.301  1.00 111.21 ? 660 PRO A CB    1 
ATOM   4198 C CG    . PRO A 1 686 ? 109.909 111.010 73.134  1.00 118.48 ? 660 PRO A CG    1 
ATOM   4199 C CD    . PRO A 1 686 ? 109.971 111.193 71.631  1.00 117.60 ? 660 PRO A CD    1 
ATOM   4200 N N     . GLU A 1 687 ? 107.435 107.684 72.657  1.00 144.54 ? 661 GLU A N     1 
ATOM   4201 C CA    . GLU A 1 687 ? 106.038 107.275 72.558  1.00 131.86 ? 661 GLU A CA    1 
ATOM   4202 C C     . GLU A 1 687 ? 105.310 107.563 73.858  1.00 131.09 ? 661 GLU A C     1 
ATOM   4203 O O     . GLU A 1 687 ? 105.895 108.147 74.757  1.00 168.85 ? 661 GLU A O     1 
ATOM   4204 C CB    . GLU A 1 687 ? 105.950 105.767 72.346  1.00 130.19 ? 661 GLU A CB    1 
ATOM   4205 C CG    . GLU A 1 687 ? 106.560 105.323 71.015  1.00 202.20 ? 661 GLU A CG    1 
ATOM   4206 C CD    . GLU A 1 687 ? 108.069 105.080 70.926  1.00 211.47 ? 661 GLU A CD    1 
ATOM   4207 O OE1   . GLU A 1 687 ? 108.845 106.016 71.209  1.00 189.19 ? 661 GLU A OE1   1 
ATOM   4208 O OE2   . GLU A 1 687 ? 108.478 103.951 70.547  1.00 207.12 ? 661 GLU A OE2   1 
ATOM   4209 N N     . ASN A 1 688 ? 104.045 107.153 73.951  1.00 126.41 ? 662 ASN A N     1 
ATOM   4210 C CA    . ASN A 1 688 ? 103.282 107.335 75.172  1.00 128.80 ? 662 ASN A CA    1 
ATOM   4211 C C     . ASN A 1 688 ? 102.205 106.262 75.270  1.00 102.91 ? 662 ASN A C     1 
ATOM   4212 O O     . ASN A 1 688 ? 101.028 106.520 75.051  1.00 126.65 ? 662 ASN A O     1 
ATOM   4213 C CB    . ASN A 1 688 ? 102.692 108.740 75.292  1.00 137.51 ? 662 ASN A CB    1 
ATOM   4214 C CG    . ASN A 1 688 ? 101.861 108.868 76.561  1.00 176.56 ? 662 ASN A CG    1 
ATOM   4215 O OD1   . ASN A 1 688 ? 102.353 108.738 77.704  1.00 115.02 ? 662 ASN A OD1   1 
ATOM   4216 N ND2   . ASN A 1 688 ? 100.568 109.094 76.373  1.00 190.39 ? 662 ASN A ND2   1 
ATOM   4217 N N     . PRO A 1 689 ? 102.562 105.029 75.641  1.00 83.17  ? 663 PRO A N     1 
ATOM   4218 C CA    . PRO A 1 689 ? 101.661 103.901 75.475  1.00 89.75  ? 663 PRO A CA    1 
ATOM   4219 C C     . PRO A 1 689 ? 100.728 103.790 76.648  1.00 85.24  ? 663 PRO A C     1 
ATOM   4220 O O     . PRO A 1 689 ? 100.842 102.823 77.389  1.00 133.64 ? 663 PRO A O     1 
ATOM   4221 C CB    . PRO A 1 689 ? 102.612 102.706 75.458  1.00 104.32 ? 663 PRO A CB    1 
ATOM   4222 C CG    . PRO A 1 689 ? 103.659 103.140 76.443  1.00 108.88 ? 663 PRO A CG    1 
ATOM   4223 C CD    . PRO A 1 689 ? 103.850 104.652 76.205  1.00 89.15  ? 663 PRO A CD    1 
ATOM   4224 N N     . LEU A 1 690 ? 99.848  104.758 76.829  1.00 64.12  ? 664 LEU A N     1 
ATOM   4225 C CA    . LEU A 1 690 ? 98.841  104.631 77.868  1.00 76.53  ? 664 LEU A CA    1 
ATOM   4226 C C     . LEU A 1 690 ? 97.639  105.395 77.349  1.00 91.58  ? 664 LEU A C     1 
ATOM   4227 O O     . LEU A 1 690 ? 97.397  106.543 77.755  1.00 92.04  ? 664 LEU A O     1 
ATOM   4228 C CB    . LEU A 1 690 ? 99.171  105.086 79.302  1.00 70.89  ? 664 LEU A CB    1 
ATOM   4229 C CG    . LEU A 1 690 ? 100.198 104.284 80.125  1.00 84.06  ? 664 LEU A CG    1 
ATOM   4230 C CD1   . LEU A 1 690 ? 99.971  104.456 81.654  1.00 79.24  ? 664 LEU A CD1   1 
ATOM   4231 C CD2   . LEU A 1 690 ? 100.289 102.821 79.809  1.00 80.92  ? 664 LEU A CD2   1 
ATOM   4232 N N     . LYS A 1 691 ? 96.864  104.758 76.473  1.00 68.64  ? 665 LYS A N     1 
ATOM   4233 C CA    . LYS A 1 691 ? 95.698  105.491 76.027  1.00 92.27  ? 665 LYS A CA    1 
ATOM   4234 C C     . LYS A 1 691 ? 94.547  105.423 77.031  1.00 81.62  ? 665 LYS A C     1 
ATOM   4235 O O     . LYS A 1 691 ? 93.987  106.459 77.395  1.00 69.49  ? 665 LYS A O     1 
ATOM   4236 C CB    . LYS A 1 691 ? 95.438  104.973 74.617  1.00 132.97 ? 665 LYS A CB    1 
ATOM   4237 C CG    . LYS A 1 691 ? 96.109  105.885 73.609  1.00 177.99 ? 665 LYS A CG    1 
ATOM   4238 C CD    . LYS A 1 691 ? 96.576  105.173 72.353  1.00 189.05 ? 665 LYS A CD    1 
ATOM   4239 C CE    . LYS A 1 691 ? 97.963  104.661 72.552  1.00 167.29 ? 665 LYS A CE    1 
ATOM   4240 N NZ    . LYS A 1 691 ? 98.932  105.737 72.336  1.00 153.49 ? 665 LYS A NZ    1 
ATOM   4241 N N     . TYR A 1 692 ? 94.235  104.179 77.445  1.00 80.71  ? 666 TYR A N     1 
ATOM   4242 C CA    . TYR A 1 692 ? 92.989  103.802 78.085  1.00 81.90  ? 666 TYR A CA    1 
ATOM   4243 C C     . TYR A 1 692 ? 93.166  103.088 79.437  1.00 86.41  ? 666 TYR A C     1 
ATOM   4244 O O     . TYR A 1 692 ? 93.930  102.111 79.585  1.00 56.72  ? 666 TYR A O     1 
ATOM   4245 C CB    . TYR A 1 692 ? 92.326  102.960 77.002  1.00 87.22  ? 666 TYR A CB    1 
ATOM   4246 C CG    . TYR A 1 692 ? 91.989  103.817 75.788  1.00 118.41 ? 666 TYR A CG    1 
ATOM   4247 C CD1   . TYR A 1 692 ? 91.294  105.036 75.911  1.00 124.58 ? 666 TYR A CD1   1 
ATOM   4248 C CD2   . TYR A 1 692 ? 92.423  103.415 74.518  1.00 89.53  ? 666 TYR A CD2   1 
ATOM   4249 C CE1   . TYR A 1 692 ? 90.984  105.782 74.781  1.00 165.87 ? 666 TYR A CE1   1 
ATOM   4250 C CE2   . TYR A 1 692 ? 92.132  104.162 73.391  1.00 122.50 ? 666 TYR A CE2   1 
ATOM   4251 C CZ    . TYR A 1 692 ? 91.408  105.346 73.527  1.00 189.74 ? 666 TYR A CZ    1 
ATOM   4252 O OH    . TYR A 1 692 ? 91.120  106.108 72.425  1.00 198.93 ? 666 TYR A OH    1 
ATOM   4253 N N     . LEU A 1 693 ? 92.365  103.577 80.408  1.00 74.67  ? 667 LEU A N     1 
ATOM   4254 C CA    . LEU A 1 693 ? 92.473  103.118 81.757  1.00 65.75  ? 667 LEU A CA    1 
ATOM   4255 C C     . LEU A 1 693 ? 91.945  101.698 81.802  1.00 91.43  ? 667 LEU A C     1 
ATOM   4256 O O     . LEU A 1 693 ? 92.779  100.819 81.598  1.00 144.76 ? 667 LEU A O     1 
ATOM   4257 C CB    . LEU A 1 693 ? 91.822  104.058 82.734  1.00 72.80  ? 667 LEU A CB    1 
ATOM   4258 C CG    . LEU A 1 693 ? 92.471  104.008 84.126  1.00 72.65  ? 667 LEU A CG    1 
ATOM   4259 C CD1   . LEU A 1 693 ? 91.682  104.788 85.190  1.00 63.87  ? 667 LEU A CD1   1 
ATOM   4260 C CD2   . LEU A 1 693 ? 92.614  102.577 84.625  1.00 75.86  ? 667 LEU A CD2   1 
ATOM   4261 N N     . TYR A 1 694 ? 90.657  101.374 82.033  1.00 76.99  ? 668 TYR A N     1 
ATOM   4262 C CA    . TYR A 1 694 ? 90.447  99.924  82.065  1.00 84.19  ? 668 TYR A CA    1 
ATOM   4263 C C     . TYR A 1 694 ? 89.552  99.471  80.933  1.00 129.15 ? 668 TYR A C     1 
ATOM   4264 O O     . TYR A 1 694 ? 90.046  98.833  80.006  1.00 190.82 ? 668 TYR A O     1 
ATOM   4265 C CB    . TYR A 1 694 ? 89.844  99.102  83.187  1.00 86.81  ? 668 TYR A CB    1 
ATOM   4266 C CG    . TYR A 1 694 ? 89.566  97.701  82.661  1.00 107.39 ? 668 TYR A CG    1 
ATOM   4267 C CD1   . TYR A 1 694 ? 90.523  97.015  81.908  1.00 119.31 ? 668 TYR A CD1   1 
ATOM   4268 C CD2   . TYR A 1 694 ? 88.328  97.085  82.851  1.00 109.79 ? 668 TYR A CD2   1 
ATOM   4269 C CE1   . TYR A 1 694 ? 90.263  95.748  81.395  1.00 132.72 ? 668 TYR A CE1   1 
ATOM   4270 C CE2   . TYR A 1 694 ? 88.079  95.800  82.383  1.00 108.00 ? 668 TYR A CE2   1 
ATOM   4271 C CZ    . TYR A 1 694 ? 89.048  95.137  81.638  1.00 115.50 ? 668 TYR A CZ    1 
ATOM   4272 O OH    . TYR A 1 694 ? 88.935  93.914  81.055  1.00 116.37 ? 668 TYR A OH    1 
ATOM   4273 N N     . PRO A 1 695 ? 88.227  99.738  80.964  1.00 127.14 ? 669 PRO A N     1 
ATOM   4274 C CA    . PRO A 1 695 ? 87.368  99.379  79.826  1.00 150.14 ? 669 PRO A CA    1 
ATOM   4275 C C     . PRO A 1 695 ? 87.545  100.294 78.587  1.00 164.39 ? 669 PRO A C     1 
ATOM   4276 O O     . PRO A 1 695 ? 88.100  99.930  77.534  1.00 112.77 ? 669 PRO A O     1 
ATOM   4277 C CB    . PRO A 1 695 ? 85.968  99.441  80.507  1.00 113.00 ? 669 PRO A CB    1 
ATOM   4278 C CG    . PRO A 1 695 ? 86.241  99.636  81.954  1.00 91.31  ? 669 PRO A CG    1 
ATOM   4279 C CD    . PRO A 1 695 ? 87.512  100.430 82.040  1.00 96.25  ? 669 PRO A CD    1 
ATOM   4280 N N     . ASN A 1 696 ? 87.098  101.538 78.718  1.00 134.51 ? 670 ASN A N     1 
ATOM   4281 C CA    . ASN A 1 696 ? 87.541  102.568 77.809  1.00 118.38 ? 670 ASN A CA    1 
ATOM   4282 C C     . ASN A 1 696 ? 87.391  103.867 78.597  1.00 112.97 ? 670 ASN A C     1 
ATOM   4283 O O     . ASN A 1 696 ? 86.293  104.392 78.814  1.00 104.89 ? 670 ASN A O     1 
ATOM   4284 C CB    . ASN A 1 696 ? 86.820  102.471 76.472  1.00 149.52 ? 670 ASN A CB    1 
ATOM   4285 C CG    . ASN A 1 696 ? 85.345  102.789 76.608  1.00 225.05 ? 670 ASN A CG    1 
ATOM   4286 O OD1   . ASN A 1 696 ? 84.502  101.900 76.443  1.00 239.42 ? 670 ASN A OD1   1 
ATOM   4287 N ND2   . ASN A 1 696 ? 85.008  104.036 76.921  1.00 243.97 ? 670 ASN A ND2   1 
ATOM   4288 N N     . ILE A 1 697 ? 88.527  104.329 79.100  1.00 102.92 ? 671 ILE A N     1 
ATOM   4289 C CA    . ILE A 1 697 ? 88.618  105.663 79.637  1.00 119.02 ? 671 ILE A CA    1 
ATOM   4290 C C     . ILE A 1 697 ? 89.952  106.239 79.132  1.00 117.70 ? 671 ILE A C     1 
ATOM   4291 O O     . ILE A 1 697 ? 90.998  105.616 79.199  1.00 78.26  ? 671 ILE A O     1 
ATOM   4292 C CB    . ILE A 1 697 ? 88.376  105.582 81.156  1.00 106.78 ? 671 ILE A CB    1 
ATOM   4293 C CG1   . ILE A 1 697 ? 87.469  104.395 81.450  1.00 106.42 ? 671 ILE A CG1   1 
ATOM   4294 C CG2   . ILE A 1 697 ? 87.802  106.884 81.743  1.00 103.81 ? 671 ILE A CG2   1 
ATOM   4295 C CD1   . ILE A 1 697 ? 87.174  104.173 82.919  1.00 154.04 ? 671 ILE A CD1   1 
ATOM   4296 N N     . ASP A 1 698 ? 89.840  107.370 78.438  1.00 139.56 ? 672 ASP A N     1 
ATOM   4297 C CA    . ASP A 1 698 ? 90.955  108.130 77.916  1.00 128.09 ? 672 ASP A CA    1 
ATOM   4298 C C     . ASP A 1 698 ? 91.675  108.798 79.076  1.00 119.04 ? 672 ASP A C     1 
ATOM   4299 O O     . ASP A 1 698 ? 91.065  109.554 79.843  1.00 86.06  ? 672 ASP A O     1 
ATOM   4300 C CB    . ASP A 1 698 ? 90.419  109.290 77.104  1.00 181.25 ? 672 ASP A CB    1 
ATOM   4301 C CG    . ASP A 1 698 ? 89.437  110.156 77.890  1.00 211.21 ? 672 ASP A CG    1 
ATOM   4302 O OD1   . ASP A 1 698 ? 88.540  109.565 78.567  1.00 152.09 ? 672 ASP A OD1   1 
ATOM   4303 O OD2   . ASP A 1 698 ? 89.589  111.403 77.842  1.00 223.26 ? 672 ASP A OD2   1 
ATOM   4304 N N     . LYS A 1 699 ? 92.988  108.554 79.134  1.00 116.77 ? 673 LYS A N     1 
ATOM   4305 C CA    . LYS A 1 699 ? 93.813  108.838 80.296  1.00 85.51  ? 673 LYS A CA    1 
ATOM   4306 C C     . LYS A 1 699 ? 93.445  110.207 80.861  1.00 87.83  ? 673 LYS A C     1 
ATOM   4307 O O     . LYS A 1 699 ? 93.254  110.374 82.067  1.00 101.40 ? 673 LYS A O     1 
ATOM   4308 C CB    . LYS A 1 699 ? 95.252  108.707 79.794  1.00 79.42  ? 673 LYS A CB    1 
ATOM   4309 C CG    . LYS A 1 699 ? 96.329  108.983 80.819  1.00 99.81  ? 673 LYS A CG    1 
ATOM   4310 C CD    . LYS A 1 699 ? 97.543  109.787 80.333  1.00 109.52 ? 673 LYS A CD    1 
ATOM   4311 C CE    . LYS A 1 699 ? 98.092  109.309 79.028  1.00 116.74 ? 673 LYS A CE    1 
ATOM   4312 N NZ    . LYS A 1 699 ? 98.340  107.864 78.999  1.00 94.21  ? 673 LYS A NZ    1 
ATOM   4313 N N     . ASP A 1 700 ? 93.316  111.188 79.979  1.00 76.48  ? 674 ASP A N     1 
ATOM   4314 C CA    . ASP A 1 700 ? 93.424  112.555 80.429  1.00 89.67  ? 674 ASP A CA    1 
ATOM   4315 C C     . ASP A 1 700 ? 92.053  112.989 80.936  1.00 89.35  ? 674 ASP A C     1 
ATOM   4316 O O     . ASP A 1 700 ? 91.759  114.187 81.015  1.00 100.97 ? 674 ASP A O     1 
ATOM   4317 C CB    . ASP A 1 700 ? 94.160  113.353 79.360  1.00 125.10 ? 674 ASP A CB    1 
ATOM   4318 C CG    . ASP A 1 700 ? 95.511  112.771 78.922  1.00 154.12 ? 674 ASP A CG    1 
ATOM   4319 O OD1   . ASP A 1 700 ? 96.551  113.052 79.576  1.00 108.22 ? 674 ASP A OD1   1 
ATOM   4320 O OD2   . ASP A 1 700 ? 95.528  112.011 77.924  1.00 183.58 ? 674 ASP A OD2   1 
ATOM   4321 N N     . HIS A 1 701 ? 91.226  111.988 81.269  1.00 95.20  ? 675 HIS A N     1 
ATOM   4322 C CA    . HIS A 1 701 ? 89.897  112.183 81.833  1.00 120.90 ? 675 HIS A CA    1 
ATOM   4323 C C     . HIS A 1 701 ? 89.829  111.427 83.159  1.00 102.28 ? 675 HIS A C     1 
ATOM   4324 O O     . HIS A 1 701 ? 89.382  111.958 84.186  1.00 93.61  ? 675 HIS A O     1 
ATOM   4325 C CB    . HIS A 1 701 ? 88.851  111.685 80.830  1.00 160.48 ? 675 HIS A CB    1 
ATOM   4326 C CG    . HIS A 1 701 ? 87.431  112.005 81.152  1.00 197.22 ? 675 HIS A CG    1 
ATOM   4327 N ND1   . HIS A 1 701 ? 86.407  111.132 80.849  1.00 209.15 ? 675 HIS A ND1   1 
ATOM   4328 C CD2   . HIS A 1 701 ? 86.857  113.074 81.721  1.00 225.30 ? 675 HIS A CD2   1 
ATOM   4329 C CE1   . HIS A 1 701 ? 85.254  111.665 81.232  1.00 232.46 ? 675 HIS A CE1   1 
ATOM   4330 N NE2   . HIS A 1 701 ? 85.503  112.843 81.767  1.00 234.75 ? 675 HIS A NE2   1 
ATOM   4331 N N     . ALA A 1 702 ? 90.311  110.179 83.102  1.00 98.38  ? 676 ALA A N     1 
ATOM   4332 C CA    . ALA A 1 702 ? 90.524  109.335 84.268  1.00 113.10 ? 676 ALA A CA    1 
ATOM   4333 C C     . ALA A 1 702 ? 91.464  109.981 85.282  1.00 103.98 ? 676 ALA A C     1 
ATOM   4334 O O     . ALA A 1 702 ? 91.095  110.171 86.437  1.00 134.66 ? 676 ALA A O     1 
ATOM   4335 C CB    . ALA A 1 702 ? 91.080  108.012 83.839  1.00 107.61 ? 676 ALA A CB    1 
ATOM   4336 N N     . PHE A 1 703 ? 92.675  110.301 84.850  1.00 76.65  ? 677 PHE A N     1 
ATOM   4337 C CA    . PHE A 1 703 ? 93.551  111.092 85.681  1.00 84.56  ? 677 PHE A CA    1 
ATOM   4338 C C     . PHE A 1 703 ? 93.500  112.550 85.242  1.00 89.67  ? 677 PHE A C     1 
ATOM   4339 O O     . PHE A 1 703 ? 94.492  113.183 84.896  1.00 88.38  ? 677 PHE A O     1 
ATOM   4340 C CB    . PHE A 1 703 ? 94.936  110.473 85.490  1.00 93.65  ? 677 PHE A CB    1 
ATOM   4341 C CG    . PHE A 1 703 ? 94.909  108.982 85.669  1.00 68.63  ? 677 PHE A CG    1 
ATOM   4342 C CD1   . PHE A 1 703 ? 94.614  108.438 86.899  1.00 79.62  ? 677 PHE A CD1   1 
ATOM   4343 C CD2   . PHE A 1 703 ? 95.109  108.146 84.597  1.00 89.72  ? 677 PHE A CD2   1 
ATOM   4344 C CE1   . PHE A 1 703 ? 94.536  107.065 87.070  1.00 80.62  ? 677 PHE A CE1   1 
ATOM   4345 C CE2   . PHE A 1 703 ? 94.992  106.773 84.753  1.00 94.91  ? 677 PHE A CE2   1 
ATOM   4346 C CZ    . PHE A 1 703 ? 94.721  106.236 85.996  1.00 87.26  ? 677 PHE A CZ    1 
ATOM   4347 N N     . GLY A 1 704 ? 92.329  113.118 85.144  1.00 103.34 ? 678 GLY A N     1 
ATOM   4348 C CA    . GLY A 1 704 ? 92.370  114.442 84.572  1.00 112.75 ? 678 GLY A CA    1 
ATOM   4349 C C     . GLY A 1 704 ? 92.783  115.384 85.672  1.00 110.28 ? 678 GLY A C     1 
ATOM   4350 O O     . GLY A 1 704 ? 93.809  116.045 85.517  1.00 74.85  ? 678 GLY A O     1 
ATOM   4351 N N     . LYS A 1 705 ? 91.983  115.262 86.765  1.00 129.32 ? 679 LYS A N     1 
ATOM   4352 C CA    . LYS A 1 705 ? 91.726  116.256 87.803  1.00 115.13 ? 679 LYS A CA    1 
ATOM   4353 C C     . LYS A 1 705 ? 92.811  116.184 88.868  1.00 109.65 ? 679 LYS A C     1 
ATOM   4354 O O     . LYS A 1 705 ? 92.955  117.093 89.681  1.00 116.28 ? 679 LYS A O     1 
ATOM   4355 C CB    . LYS A 1 705 ? 90.366  116.053 88.481  1.00 91.46  ? 679 LYS A CB    1 
ATOM   4356 C CG    . LYS A 1 705 ? 90.112  114.645 89.021  1.00 116.35 ? 679 LYS A CG    1 
ATOM   4357 C CD    . LYS A 1 705 ? 89.029  114.403 90.088  1.00 144.77 ? 679 LYS A CD    1 
ATOM   4358 C CE    . LYS A 1 705 ? 87.610  114.824 89.774  1.00 172.42 ? 679 LYS A CE    1 
ATOM   4359 N NZ    . LYS A 1 705 ? 86.953  114.126 88.667  1.00 177.21 ? 679 LYS A NZ    1 
ATOM   4360 N N     . TYR A 1 706 ? 93.618  115.128 88.792  1.00 111.82 ? 680 TYR A N     1 
ATOM   4361 C CA    . TYR A 1 706 ? 94.672  114.908 89.758  1.00 112.91 ? 680 TYR A CA    1 
ATOM   4362 C C     . TYR A 1 706 ? 96.024  115.452 89.338  1.00 108.06 ? 680 TYR A C     1 
ATOM   4363 O O     . TYR A 1 706 ? 96.865  115.725 90.199  1.00 106.14 ? 680 TYR A O     1 
ATOM   4364 C CB    . TYR A 1 706 ? 94.884  113.414 89.859  1.00 106.30 ? 680 TYR A CB    1 
ATOM   4365 C CG    . TYR A 1 706 ? 93.587  112.699 90.149  1.00 104.62 ? 680 TYR A CG    1 
ATOM   4366 C CD1   . TYR A 1 706 ? 92.699  113.133 91.141  1.00 70.54  ? 680 TYR A CD1   1 
ATOM   4367 C CD2   . TYR A 1 706 ? 93.288  111.569 89.402  1.00 106.93 ? 680 TYR A CD2   1 
ATOM   4368 C CE1   . TYR A 1 706 ? 91.544  112.406 91.375  1.00 89.48  ? 680 TYR A CE1   1 
ATOM   4369 C CE2   . TYR A 1 706 ? 92.142  110.839 89.647  1.00 114.55 ? 680 TYR A CE2   1 
ATOM   4370 C CZ    . TYR A 1 706 ? 91.260  111.261 90.624  1.00 97.91  ? 680 TYR A CZ    1 
ATOM   4371 O OH    . TYR A 1 706 ? 90.121  110.487 90.687  1.00 83.92  ? 680 TYR A OH    1 
ATOM   4372 N N     . TYR A 1 707 ? 96.259  115.505 88.029  1.00 106.63 ? 681 TYR A N     1 
ATOM   4373 C CA    . TYR A 1 707 ? 97.418  116.223 87.554  1.00 109.15 ? 681 TYR A CA    1 
ATOM   4374 C C     . TYR A 1 707 ? 97.535  117.541 88.301  1.00 120.97 ? 681 TYR A C     1 
ATOM   4375 O O     . TYR A 1 707 ? 96.496  118.160 88.601  1.00 77.58  ? 681 TYR A O     1 
ATOM   4376 C CB    . TYR A 1 707 ? 97.327  116.721 86.124  1.00 101.80 ? 681 TYR A CB    1 
ATOM   4377 C CG    . TYR A 1 707 ? 97.113  115.623 85.119  1.00 92.97  ? 681 TYR A CG    1 
ATOM   4378 C CD1   . TYR A 1 707 ? 97.498  114.332 85.398  1.00 80.88  ? 681 TYR A CD1   1 
ATOM   4379 C CD2   . TYR A 1 707 ? 96.583  115.909 83.868  1.00 108.00 ? 681 TYR A CD2   1 
ATOM   4380 C CE1   . TYR A 1 707 ? 97.345  113.342 84.440  1.00 88.19  ? 681 TYR A CE1   1 
ATOM   4381 C CE2   . TYR A 1 707 ? 96.410  114.925 82.918  1.00 83.70  ? 681 TYR A CE2   1 
ATOM   4382 C CZ    . TYR A 1 707 ? 96.770  113.633 83.216  1.00 67.31  ? 681 TYR A CZ    1 
ATOM   4383 O OH    . TYR A 1 707 ? 96.558  112.697 82.271  1.00 64.78  ? 681 TYR A OH    1 
ATOM   4384 N N     . SER A 1 708 ? 98.807  117.957 88.480  1.00 109.88 ? 682 SER A N     1 
ATOM   4385 C CA    . SER A 1 708 ? 99.184  119.191 89.157  1.00 133.94 ? 682 SER A CA    1 
ATOM   4386 C C     . SER A 1 708 ? 99.409  120.318 88.149  1.00 178.04 ? 682 SER A C     1 
ATOM   4387 O O     . SER A 1 708 ? 100.212 120.160 87.224  1.00 172.35 ? 682 SER A O     1 
ATOM   4388 C CB    . SER A 1 708 ? 100.417 118.930 89.914  1.00 121.31 ? 682 SER A CB    1 
ATOM   4389 O OG    . SER A 1 708 ? 101.156 117.998 89.142  1.00 114.67 ? 682 SER A OG    1 
ATOM   4390 N N     . ARG A 1 709 ? 98.697  121.440 88.349  1.00 189.41 ? 683 ARG A N     1 
ATOM   4391 C CA    . ARG A 1 709 ? 98.758  122.615 87.484  1.00 238.24 ? 683 ARG A CA    1 
ATOM   4392 C C     . ARG A 1 709 ? 97.921  122.377 86.213  1.00 258.34 ? 683 ARG A C     1 
ATOM   4393 O O     . ARG A 1 709 ? 96.687  122.434 86.293  1.00 176.57 ? 683 ARG A O     1 
ATOM   4394 C CB    . ARG A 1 709 ? 100.211 123.110 87.365  1.00 253.30 ? 683 ARG A CB    1 
ATOM   4395 C CG    . ARG A 1 709 ? 100.416 124.403 86.586  1.00 255.93 ? 683 ARG A CG    1 
ATOM   4396 C CD    . ARG A 1 709 ? 101.890 124.673 86.307  1.00 272.07 ? 683 ARG A CD    1 
ATOM   4397 N NE    . ARG A 1 709 ? 102.644 125.031 87.515  1.00 292.64 ? 683 ARG A NE    1 
ATOM   4398 C CZ    . ARG A 1 709 ? 103.532 124.275 88.162  1.00 313.47 ? 683 ARG A CZ    1 
ATOM   4399 N NH1   . ARG A 1 709 ? 103.764 123.024 87.794  1.00 321.03 ? 683 ARG A NH1   1 
ATOM   4400 N NH2   . ARG A 1 709 ? 104.178 124.776 89.203  1.00 320.67 ? 683 ARG A NH2   1 
ATOM   4401 N N     . PRO A 1 710 ? 98.512  122.076 85.018  1.00 302.06 ? 684 PRO A N     1 
ATOM   4402 C CA    . PRO A 1 710 ? 97.799  122.208 83.738  1.00 288.08 ? 684 PRO A CA    1 
ATOM   4403 C C     . PRO A 1 710 ? 97.085  120.957 83.193  1.00 242.00 ? 684 PRO A C     1 
ATOM   4404 O O     . PRO A 1 710 ? 97.294  120.533 82.021  1.00 134.54 ? 684 PRO A O     1 
ATOM   4405 C CB    . PRO A 1 710 ? 98.995  122.611 82.856  1.00 305.79 ? 684 PRO A CB    1 
ATOM   4406 C CG    . PRO A 1 710 ? 100.104 121.685 83.315  1.00 320.63 ? 684 PRO A CG    1 
ATOM   4407 C CD    . PRO A 1 710 ? 99.861  121.512 84.809  1.00 314.11 ? 684 PRO A CD    1 
ATOM   4408 N N     . THR A 1 725 ? 117.681 136.366 85.188  1.00 235.27 ? 699 THR A N     1 
ATOM   4409 C CA    . THR A 1 725 ? 117.007 136.912 83.982  1.00 252.24 ? 699 THR A CA    1 
ATOM   4410 C C     . THR A 1 725 ? 115.848 136.005 83.551  1.00 228.16 ? 699 THR A C     1 
ATOM   4411 O O     . THR A 1 725 ? 115.085 136.348 82.641  1.00 211.88 ? 699 THR A O     1 
ATOM   4412 C CB    . THR A 1 725 ? 118.045 137.104 82.875  1.00 252.01 ? 699 THR A CB    1 
ATOM   4413 O OG1   . THR A 1 725 ? 118.950 138.065 83.413  1.00 251.93 ? 699 THR A OG1   1 
ATOM   4414 C CG2   . THR A 1 725 ? 117.453 137.608 81.568  1.00 236.34 ? 699 THR A CG2   1 
ATOM   4415 N N     . GLY A 1 726 ? 115.724 134.842 84.204  1.00 165.19 ? 700 GLY A N     1 
ATOM   4416 C CA    . GLY A 1 726 ? 114.547 134.009 84.050  1.00 139.72 ? 700 GLY A CA    1 
ATOM   4417 C C     . GLY A 1 726 ? 114.948 132.549 83.973  1.00 116.19 ? 700 GLY A C     1 
ATOM   4418 O O     . GLY A 1 726 ? 115.333 132.083 82.911  1.00 116.41 ? 700 GLY A O     1 
HETATM 4419 N N     . PTR A 1 727 ? 114.866 131.838 85.097  1.00 103.31 ? 701 PTR A N     1 
HETATM 4420 C CA    . PTR A 1 727 ? 115.210 130.426 85.087  1.00 94.87  ? 701 PTR A CA    1 
HETATM 4421 C C     . PTR A 1 727 ? 114.249 129.664 84.175  1.00 99.03  ? 701 PTR A C     1 
HETATM 4422 O O     . PTR A 1 727 ? 113.089 130.068 84.031  1.00 103.00 ? 701 PTR A O     1 
HETATM 4423 C CB    . PTR A 1 727 ? 115.117 129.856 86.495  1.00 97.92  ? 701 PTR A CB    1 
HETATM 4424 C CG    . PTR A 1 727 ? 116.207 130.290 87.426  1.00 91.80  ? 701 PTR A CG    1 
HETATM 4425 C CD1   . PTR A 1 727 ? 115.940 130.987 88.585  1.00 98.22  ? 701 PTR A CD1   1 
HETATM 4426 C CD2   . PTR A 1 727 ? 117.508 129.956 87.150  1.00 109.98 ? 701 PTR A CD2   1 
HETATM 4427 C CE1   . PTR A 1 727 ? 116.943 131.379 89.448  1.00 100.65 ? 701 PTR A CE1   1 
HETATM 4428 C CE2   . PTR A 1 727 ? 118.541 130.348 87.974  1.00 109.05 ? 701 PTR A CE2   1 
HETATM 4429 C CZ    . PTR A 1 727 ? 118.244 131.036 89.133  1.00 129.54 ? 701 PTR A CZ    1 
HETATM 4430 O OH    . PTR A 1 727 ? 119.366 131.370 89.904  1.00 134.60 ? 701 PTR A OH    1 
HETATM 4431 P P     . PTR A 1 727 ? 119.429 132.428 91.067  1.00 93.48  ? 701 PTR A P     1 
HETATM 4432 O O1P   . PTR A 1 727 ? 118.507 133.588 90.651  1.00 95.26  ? 701 PTR A O1P   1 
HETATM 4433 O O2P   . PTR A 1 727 ? 119.113 131.891 92.447  1.00 69.92  ? 701 PTR A O2P   1 
HETATM 4434 O O3P   . PTR A 1 727 ? 120.825 132.847 91.035  1.00 101.56 ? 701 PTR A O3P   1 
ATOM   4435 N N     . ILE A 1 728 ? 114.731 128.549 83.608  1.00 73.93  ? 702 ILE A N     1 
ATOM   4436 C CA    . ILE A 1 728 ? 113.971 127.737 82.658  1.00 74.80  ? 702 ILE A CA    1 
ATOM   4437 C C     . ILE A 1 728 ? 113.417 126.533 83.413  1.00 92.92  ? 702 ILE A C     1 
ATOM   4438 O O     . ILE A 1 728 ? 114.182 125.889 84.131  1.00 118.66 ? 702 ILE A O     1 
ATOM   4439 C CB    . ILE A 1 728 ? 114.940 127.321 81.551  1.00 73.79  ? 702 ILE A CB    1 
ATOM   4440 C CG1   . ILE A 1 728 ? 114.969 128.319 80.501  1.00 89.89  ? 702 ILE A CG1   1 
ATOM   4441 C CG2   . ILE A 1 728 ? 114.686 125.945 80.972  1.00 79.80  ? 702 ILE A CG2   1 
ATOM   4442 C CD1   . ILE A 1 728 ? 116.311 128.324 79.793  1.00 117.96 ? 702 ILE A CD1   1 
ATOM   4443 N N     . LYS A 1 729 ? 112.130 126.204 83.252  1.00 72.12  ? 703 LYS A N     1 
ATOM   4444 C CA    . LYS A 1 729 ? 111.485 125.312 84.200  1.00 69.97  ? 703 LYS A CA    1 
ATOM   4445 C C     . LYS A 1 729 ? 111.753 123.865 83.789  1.00 83.99  ? 703 LYS A C     1 
ATOM   4446 O O     . LYS A 1 729 ? 111.894 123.539 82.603  1.00 79.07  ? 703 LYS A O     1 
ATOM   4447 C CB    . LYS A 1 729 ? 109.972 125.505 84.288  1.00 89.36  ? 703 LYS A CB    1 
ATOM   4448 C CG    . LYS A 1 729 ? 109.550 126.932 84.520  1.00 143.79 ? 703 LYS A CG    1 
ATOM   4449 C CD    . LYS A 1 729 ? 109.463 127.789 83.263  1.00 191.31 ? 703 LYS A CD    1 
ATOM   4450 C CE    . LYS A 1 729 ? 109.607 129.244 83.586  1.00 241.73 ? 703 LYS A CE    1 
ATOM   4451 N NZ    . LYS A 1 729 ? 109.671 130.046 82.361  1.00 283.02 ? 703 LYS A NZ    1 
ATOM   4452 N N     . THR A 1 730 ? 111.791 122.982 84.788  1.00 73.10  ? 704 THR A N     1 
ATOM   4453 C CA    . THR A 1 730 ? 112.019 121.578 84.511  1.00 78.02  ? 704 THR A CA    1 
ATOM   4454 C C     . THR A 1 730 ? 110.897 120.797 85.177  1.00 82.13  ? 704 THR A C     1 
ATOM   4455 O O     . THR A 1 730 ? 110.140 121.360 85.958  1.00 110.13 ? 704 THR A O     1 
ATOM   4456 C CB    . THR A 1 730 ? 113.386 121.084 85.004  1.00 81.87  ? 704 THR A CB    1 
ATOM   4457 O OG1   . THR A 1 730 ? 113.395 120.909 86.420  1.00 88.08  ? 704 THR A OG1   1 
ATOM   4458 C CG2   . THR A 1 730 ? 114.518 122.014 84.622  1.00 89.63  ? 704 THR A CG2   1 
ATOM   4459 N N     . GLU A 1 731 ? 110.849 119.497 84.862  1.00 88.23  ? 705 GLU A N     1 
ATOM   4460 C CA    . GLU A 1 731 ? 109.943 118.512 85.426  1.00 76.19  ? 705 GLU A CA    1 
ATOM   4461 C C     . GLU A 1 731 ? 110.742 117.230 85.627  1.00 77.34  ? 705 GLU A C     1 
ATOM   4462 O O     . GLU A 1 731 ? 111.661 116.944 84.858  1.00 97.64  ? 705 GLU A O     1 
ATOM   4463 C CB    . GLU A 1 731 ? 108.784 118.240 84.467  1.00 87.44  ? 705 GLU A CB    1 
ATOM   4464 C CG    . GLU A 1 731 ? 108.159 119.547 83.983  1.00 147.51 ? 705 GLU A CG    1 
ATOM   4465 C CD    . GLU A 1 731 ? 106.653 119.574 83.762  1.00 223.82 ? 705 GLU A CD    1 
ATOM   4466 O OE1   . GLU A 1 731 ? 106.055 118.487 83.579  1.00 267.88 ? 705 GLU A OE1   1 
ATOM   4467 O OE2   . GLU A 1 731 ? 106.071 120.691 83.812  1.00 211.15 ? 705 GLU A OE2   1 
ATOM   4468 N N     . LEU A 1 732 ? 110.403 116.459 86.656  1.00 66.81  ? 706 LEU A N     1 
ATOM   4469 C CA    . LEU A 1 732 ? 110.761 115.057 86.670  1.00 61.85  ? 706 LEU A CA    1 
ATOM   4470 C C     . LEU A 1 732 ? 109.706 114.203 85.917  1.00 80.88  ? 706 LEU A C     1 
ATOM   4471 O O     . LEU A 1 732 ? 108.531 114.608 85.717  1.00 62.60  ? 706 LEU A O     1 
ATOM   4472 C CB    . LEU A 1 732 ? 110.832 114.752 88.151  1.00 63.15  ? 706 LEU A CB    1 
ATOM   4473 C CG    . LEU A 1 732 ? 112.184 114.983 88.817  1.00 98.88  ? 706 LEU A CG    1 
ATOM   4474 C CD1   . LEU A 1 732 ? 111.901 114.468 90.234  1.00 123.59 ? 706 LEU A CD1   1 
ATOM   4475 C CD2   . LEU A 1 732 ? 113.483 114.339 88.227  1.00 85.31  ? 706 LEU A CD2   1 
ATOM   4476 N N     . ILE A 1 733 ? 110.145 113.005 85.481  1.00 57.69  ? 707 ILE A N     1 
ATOM   4477 C CA    . ILE A 1 733 ? 109.437 112.223 84.486  1.00 57.38  ? 707 ILE A CA    1 
ATOM   4478 C C     . ILE A 1 733 ? 110.020 110.815 84.478  1.00 84.78  ? 707 ILE A C     1 
ATOM   4479 O O     . ILE A 1 733 ? 111.265 110.659 84.552  1.00 67.95  ? 707 ILE A O     1 
ATOM   4480 C CB    . ILE A 1 733 ? 109.563 112.967 83.141  1.00 60.86  ? 707 ILE A CB    1 
ATOM   4481 C CG1   . ILE A 1 733 ? 108.221 113.492 82.747  1.00 73.44  ? 707 ILE A CG1   1 
ATOM   4482 C CG2   . ILE A 1 733 ? 110.229 112.237 81.949  1.00 59.99  ? 707 ILE A CG2   1 
ATOM   4483 C CD1   . ILE A 1 733 ? 108.258 114.060 81.333  1.00 114.25 ? 707 ILE A CD1   1 
ATOM   4484 N N     . SER A 1 734 ? 109.127 109.799 84.398  1.00 75.72  ? 708 SER A N     1 
ATOM   4485 C CA    . SER A 1 734 ? 109.656 108.442 84.430  1.00 83.74  ? 708 SER A CA    1 
ATOM   4486 C C     . SER A 1 734 ? 109.751 107.851 83.042  1.00 67.64  ? 708 SER A C     1 
ATOM   4487 O O     . SER A 1 734 ? 108.783 107.929 82.279  1.00 77.36  ? 708 SER A O     1 
ATOM   4488 C CB    . SER A 1 734 ? 108.920 107.490 85.308  1.00 86.94  ? 708 SER A CB    1 
ATOM   4489 O OG    . SER A 1 734 ? 109.647 106.259 85.391  1.00 62.52  ? 708 SER A OG    1 
ATOM   4490 N N     . VAL A 1 735 ? 110.891 107.206 82.775  1.00 52.39  ? 709 VAL A N     1 
ATOM   4491 C CA    . VAL A 1 735 ? 111.144 106.811 81.414  1.00 62.97  ? 709 VAL A CA    1 
ATOM   4492 C C     . VAL A 1 735 ? 111.758 105.437 81.285  1.00 76.92  ? 709 VAL A C     1 
ATOM   4493 O O     . VAL A 1 735 ? 112.594 105.051 82.090  1.00 104.09 ? 709 VAL A O     1 
ATOM   4494 C CB    . VAL A 1 735 ? 112.057 107.870 80.841  1.00 64.62  ? 709 VAL A CB    1 
ATOM   4495 C CG1   . VAL A 1 735 ? 112.907 107.261 79.734  1.00 95.18  ? 709 VAL A CG1   1 
ATOM   4496 C CG2   . VAL A 1 735 ? 111.189 109.042 80.367  1.00 76.47  ? 709 VAL A CG2   1 
ATOM   4497 N N     . SER A 1 736 ? 111.386 104.738 80.210  1.00 82.49  ? 710 SER A N     1 
ATOM   4498 C CA    . SER A 1 736 ? 111.860 103.377 80.058  1.00 92.00  ? 710 SER A CA    1 
ATOM   4499 C C     . SER A 1 736 ? 112.711 103.291 78.811  1.00 99.25  ? 710 SER A C     1 
ATOM   4500 O O     . SER A 1 736 ? 112.434 104.064 77.900  1.00 85.55  ? 710 SER A O     1 
ATOM   4501 C CB    . SER A 1 736 ? 110.741 102.438 79.957  1.00 88.80  ? 710 SER A CB    1 
ATOM   4502 O OG    . SER A 1 736 ? 109.901 102.561 81.087  1.00 97.28  ? 710 SER A OG    1 
ATOM   4503 N N     . GLU A 1 737 ? 113.694 102.362 78.837  1.00 101.64 ? 711 GLU A N     1 
ATOM   4504 C CA    . GLU A 1 737 ? 114.581 101.967 77.738  1.00 110.42 ? 711 GLU A CA    1 
ATOM   4505 C C     . GLU A 1 737 ? 115.699 103.007 77.463  1.00 105.49 ? 711 GLU A C     1 
ATOM   4506 O O     . GLU A 1 737 ? 115.699 104.099 78.102  1.00 103.91 ? 711 GLU A O     1 
ATOM   4507 C CB    . GLU A 1 737 ? 113.852 101.595 76.446  1.00 110.68 ? 711 GLU A CB    1 
ATOM   4508 C CG    . GLU A 1 737 ? 114.770 100.893 75.450  1.00 147.50 ? 711 GLU A CG    1 
ATOM   4509 C CD    . GLU A 1 737 ? 114.618 99.387  75.449  1.00 189.52 ? 711 GLU A CD    1 
ATOM   4510 O OE1   . GLU A 1 737 ? 113.530 98.954  75.899  1.00 190.06 ? 711 GLU A OE1   1 
ATOM   4511 O OE2   . GLU A 1 737 ? 115.555 98.661  75.024  1.00 179.48 ? 711 GLU A OE2   1 
ATOM   4512 P P     . DA  B 2 1   ? 92.634  138.389 116.505 0.50 199.79 ? 1   DA  C P     1 
ATOM   4513 O OP1   . DA  B 2 1   ? 91.560  138.685 115.475 0.50 224.93 ? 1   DA  C OP1   1 
ATOM   4514 O OP2   . DA  B 2 1   ? 92.783  136.901 116.794 0.50 158.89 ? 1   DA  C OP2   1 
ATOM   4515 O "O5'" . DA  B 2 1   ? 94.033  138.903 115.850 0.50 240.91 ? 1   DA  C "O5'" 1 
ATOM   4516 C "C5'" . DA  B 2 1   ? 94.602  140.171 116.299 0.50 248.69 ? 1   DA  C "C5'" 1 
ATOM   4517 C "C4'" . DA  B 2 1   ? 96.093  140.208 116.035 0.50 219.97 ? 1   DA  C "C4'" 1 
ATOM   4518 O "O4'" . DA  B 2 1   ? 96.816  140.317 117.284 0.50 182.12 ? 1   DA  C "O4'" 1 
ATOM   4519 C "C3'" . DA  B 2 1   ? 96.677  138.988 115.326 0.50 182.65 ? 1   DA  C "C3'" 1 
ATOM   4520 O "O3'" . DA  B 2 1   ? 97.719  139.476 114.495 0.50 182.38 ? 1   DA  C "O3'" 1 
ATOM   4521 C "C2'" . DA  B 2 1   ? 97.218  138.150 116.481 0.50 146.82 ? 1   DA  C "C2'" 1 
ATOM   4522 C "C1'" . DA  B 2 1   ? 97.749  139.242 117.393 0.50 146.10 ? 1   DA  C "C1'" 1 
ATOM   4523 N N9    . DA  B 2 1   ? 97.876  138.896 118.805 0.50 118.29 ? 1   DA  C N9    1 
ATOM   4524 C C8    . DA  B 2 1   ? 96.934  138.235 119.543 0.50 106.42 ? 1   DA  C C8    1 
ATOM   4525 N N7    . DA  B 2 1   ? 97.280  138.085 120.797 0.50 143.55 ? 1   DA  C N7    1 
ATOM   4526 C C5    . DA  B 2 1   ? 98.531  138.686 120.908 0.50 142.94 ? 1   DA  C C5    1 
ATOM   4527 C C6    . DA  B 2 1   ? 99.427  138.848 122.001 0.50 111.52 ? 1   DA  C C6    1 
ATOM   4528 N N6    . DA  B 2 1   ? 99.187  138.420 123.243 0.50 75.58  ? 1   DA  C N6    1 
ATOM   4529 N N1    . DA  B 2 1   ? 100.586 139.515 121.756 0.50 114.24 ? 1   DA  C N1    1 
ATOM   4530 C C2    . DA  B 2 1   ? 100.814 139.967 120.510 0.50 119.26 ? 1   DA  C C2    1 
ATOM   4531 N N3    . DA  B 2 1   ? 100.050 139.866 119.421 0.50 126.21 ? 1   DA  C N3    1 
ATOM   4532 C C4    . DA  B 2 1   ? 98.905  139.205 119.679 0.50 132.33 ? 1   DA  C C4    1 
ATOM   4533 P P     . DC  B 2 2   ? 98.168  138.702 113.164 0.50 204.02 ? 2   DC  C P     1 
ATOM   4534 O OP1   . DC  B 2 2   ? 97.689  139.403 111.938 0.50 196.62 ? 2   DC  C OP1   1 
ATOM   4535 O OP2   . DC  B 2 2   ? 97.855  137.252 113.325 0.50 206.67 ? 2   DC  C OP2   1 
ATOM   4536 O "O5'" . DC  B 2 2   ? 99.746  138.953 113.275 0.50 193.12 ? 2   DC  C "O5'" 1 
ATOM   4537 C "C5'" . DC  B 2 2   ? 100.270 139.816 114.331 0.50 157.68 ? 2   DC  C "C5'" 1 
ATOM   4538 C "C4'" . DC  B 2 2   ? 101.674 139.378 114.704 0.50 137.42 ? 2   DC  C "C4'" 1 
ATOM   4539 O "O4'" . DC  B 2 2   ? 101.689 138.836 116.044 0.50 116.89 ? 2   DC  C "O4'" 1 
ATOM   4540 C "C3'" . DC  B 2 2   ? 102.290 138.288 113.821 0.50 143.84 ? 2   DC  C "C3'" 1 
ATOM   4541 O "O3'" . DC  B 2 2   ? 103.682 138.573 113.698 0.50 160.36 ? 2   DC  C "O3'" 1 
ATOM   4542 C "C2'" . DC  B 2 2   ? 102.014 137.009 114.604 0.50 106.66 ? 2   DC  C "C2'" 1 
ATOM   4543 C "C1'" . DC  B 2 2   ? 102.154 137.499 116.033 0.50 99.75  ? 2   DC  C "C1'" 1 
ATOM   4544 N N1    . DC  B 2 2   ? 101.384 136.727 117.039 0.50 103.11 ? 2   DC  C N1    1 
ATOM   4545 C C2    . DC  B 2 2   ? 101.755 136.837 118.379 0.50 98.43  ? 2   DC  C C2    1 
ATOM   4546 O O2    . DC  B 2 2   ? 102.712 137.575 118.662 0.50 109.73 ? 2   DC  C O2    1 
ATOM   4547 N N3    . DC  B 2 2   ? 101.083 136.125 119.316 0.50 99.80  ? 2   DC  C N3    1 
ATOM   4548 C C4    . DC  B 2 2   ? 100.049 135.350 118.969 0.50 104.53 ? 2   DC  C C4    1 
ATOM   4549 N N4    . DC  B 2 2   ? 99.419  134.679 119.926 0.50 103.83 ? 2   DC  C N4    1 
ATOM   4550 C C5    . DC  B 2 2   ? 99.649  135.236 117.611 0.50 111.66 ? 2   DC  C C5    1 
ATOM   4551 C C6    . DC  B 2 2   ? 100.342 135.926 116.688 0.50 113.57 ? 2   DC  C C6    1 
ATOM   4552 P P     . DA  B 2 3   ? 104.609 137.981 112.520 0.50 170.29 ? 3   DA  C P     1 
ATOM   4553 O OP1   . DA  B 2 3   ? 104.994 139.042 111.542 0.50 135.93 ? 3   DA  C OP1   1 
ATOM   4554 O OP2   . DA  B 2 3   ? 104.086 136.687 111.993 0.50 154.48 ? 3   DA  C OP2   1 
ATOM   4555 O "O5'" . DA  B 2 3   ? 105.862 137.705 113.479 0.50 182.76 ? 3   DA  C "O5'" 1 
ATOM   4556 C "C5'" . DA  B 2 3   ? 105.966 138.487 114.707 0.50 182.50 ? 3   DA  C "C5'" 1 
ATOM   4557 C "C4'" . DA  B 2 3   ? 106.906 137.828 115.693 0.50 163.19 ? 3   DA  C "C4'" 1 
ATOM   4558 O "O4'" . DA  B 2 3   ? 106.142 137.124 116.700 0.50 141.03 ? 3   DA  C "O4'" 1 
ATOM   4559 C "C3'" . DA  B 2 3   ? 107.879 136.814 115.098 0.50 155.69 ? 3   DA  C "C3'" 1 
ATOM   4560 O "O3'" . DA  B 2 3   ? 109.100 136.922 115.828 0.50 174.23 ? 3   DA  C "O3'" 1 
ATOM   4561 C "C2'" . DA  B 2 3   ? 107.152 135.495 115.353 0.50 148.77 ? 3   DA  C "C2'" 1 
ATOM   4562 C "C1'" . DA  B 2 3   ? 106.498 135.744 116.701 0.50 122.24 ? 3   DA  C "C1'" 1 
ATOM   4563 N N9    . DA  B 2 3   ? 105.287 134.967 116.961 0.50 113.74 ? 3   DA  C N9    1 
ATOM   4564 C C8    . DA  B 2 3   ? 104.322 134.473 116.112 0.50 127.49 ? 3   DA  C C8    1 
ATOM   4565 N N7    . DA  B 2 3   ? 103.360 133.829 116.733 0.50 125.10 ? 3   DA  C N7    1 
ATOM   4566 C C5    . DA  B 2 3   ? 103.702 133.906 118.080 0.50 109.40 ? 3   DA  C C5    1 
ATOM   4567 C C6    . DA  B 2 3   ? 103.076 133.429 119.255 0.50 84.92  ? 3   DA  C C6    1 
ATOM   4568 N N6    . DA  B 2 3   ? 101.930 132.760 119.280 0.50 86.87  ? 3   DA  C N6    1 
ATOM   4569 N N1    . DA  B 2 3   ? 103.701 133.660 120.426 0.50 76.66  ? 3   DA  C N1    1 
ATOM   4570 C C2    . DA  B 2 3   ? 104.842 134.363 120.401 0.50 86.50  ? 3   DA  C C2    1 
ATOM   4571 N N3    . DA  B 2 3   ? 105.516 134.877 119.373 0.50 81.42  ? 3   DA  C N3    1 
ATOM   4572 C C4    . DA  B 2 3   ? 104.891 134.602 118.225 0.50 96.63  ? 3   DA  C C4    1 
ATOM   4573 P P     . DG  B 2 4   ? 110.527 136.430 115.266 0.50 169.64 ? 4   DG  C P     1 
ATOM   4574 O OP1   . DG  B 2 4   ? 111.427 137.584 114.968 0.50 139.39 ? 4   DG  C OP1   1 
ATOM   4575 O OP2   . DG  B 2 4   ? 110.336 135.395 114.210 0.50 167.06 ? 4   DG  C OP2   1 
ATOM   4576 O "O5'" . DG  B 2 4   ? 111.071 135.713 116.594 0.50 138.10 ? 4   DG  C "O5'" 1 
ATOM   4577 C "C5'" . DG  B 2 4   ? 110.858 136.372 117.875 0.50 117.96 ? 4   DG  C "C5'" 1 
ATOM   4578 C "C4'" . DG  B 2 4   ? 110.944 135.380 119.006 0.50 100.40 ? 4   DG  C "C4'" 1 
ATOM   4579 O "O4'" . DG  B 2 4   ? 109.681 134.695 119.157 0.50 103.89 ? 4   DG  C "O4'" 1 
ATOM   4580 C "C3'" . DG  B 2 4   ? 112.002 134.305 118.852 0.50 97.95  ? 4   DG  C "C3'" 1 
ATOM   4581 O "O3'" . DG  B 2 4   ? 112.627 134.181 120.123 0.50 105.19 ? 4   DG  C "O3'" 1 
ATOM   4582 C "C2'" . DG  B 2 4   ? 111.180 133.086 118.429 0.50 105.78 ? 4   DG  C "C2'" 1 
ATOM   4583 C "C1'" . DG  B 2 4   ? 109.864 133.285 119.149 0.50 87.63  ? 4   DG  C "C1'" 1 
ATOM   4584 N N9    . DG  B 2 4   ? 108.687 132.708 118.503 0.50 86.75  ? 4   DG  C N9    1 
ATOM   4585 C C8    . DG  B 2 4   ? 108.248 132.688 117.203 0.50 93.37  ? 4   DG  C C8    1 
ATOM   4586 N N7    . DG  B 2 4   ? 107.088 132.091 117.059 0.50 105.75 ? 4   DG  C N7    1 
ATOM   4587 C C5    . DG  B 2 4   ? 106.728 131.722 118.349 0.50 83.71  ? 4   DG  C C5    1 
ATOM   4588 C C6    . DG  B 2 4   ? 105.567 131.054 118.821 0.50 84.32  ? 4   DG  C C6    1 
ATOM   4589 O O6    . DG  B 2 4   ? 104.593 130.612 118.192 0.50 92.51  ? 4   DG  C O6    1 
ATOM   4590 N N1    . DG  B 2 4   ? 105.631 130.903 120.197 0.50 82.71  ? 4   DG  C N1    1 
ATOM   4591 C C2    . DG  B 2 4   ? 106.660 131.341 121.001 0.50 90.53  ? 4   DG  C C2    1 
ATOM   4592 N N2    . DG  B 2 4   ? 106.533 131.098 122.311 0.50 103.32 ? 4   DG  C N2    1 
ATOM   4593 N N3    . DG  B 2 4   ? 107.754 131.957 120.568 0.50 70.95  ? 4   DG  C N3    1 
ATOM   4594 C C4    . DG  B 2 4   ? 107.719 132.086 119.234 0.50 71.60  ? 4   DG  C C4    1 
ATOM   4595 P P     . DT  B 2 5   ? 114.120 133.605 120.311 0.50 94.00  ? 5   DT  C P     1 
ATOM   4596 O OP1   . DT  B 2 5   ? 114.982 134.390 121.243 0.50 80.90  ? 5   DT  C OP1   1 
ATOM   4597 O OP2   . DT  B 2 5   ? 114.688 133.200 118.996 0.50 124.22 ? 5   DT  C OP2   1 
ATOM   4598 O "O5'" . DT  B 2 5   ? 113.694 132.280 121.095 0.50 88.53  ? 5   DT  C "O5'" 1 
ATOM   4599 C "C5'" . DT  B 2 5   ? 112.769 132.450 122.190 0.50 83.28  ? 5   DT  C "C5'" 1 
ATOM   4600 C "C4'" . DT  B 2 5   ? 112.104 131.150 122.561 0.50 78.20  ? 5   DT  C "C4'" 1 
ATOM   4601 O "O4'" . DT  B 2 5   ? 111.001 130.858 121.668 0.50 82.78  ? 5   DT  C "O4'" 1 
ATOM   4602 C "C3'" . DT  B 2 5   ? 112.995 129.918 122.577 0.50 72.94  ? 5   DT  C "C3'" 1 
ATOM   4603 O "O3'" . DT  B 2 5   ? 112.962 129.358 123.884 0.50 68.68  ? 5   DT  C "O3'" 1 
ATOM   4604 C "C2'" . DT  B 2 5   ? 112.417 129.072 121.441 0.50 73.77  ? 5   DT  C "C2'" 1 
ATOM   4605 C "C1'" . DT  B 2 5   ? 110.958 129.454 121.475 0.50 72.37  ? 5   DT  C "C1'" 1 
ATOM   4606 N N1    . DT  B 2 5   ? 110.127 129.166 120.291 0.50 68.55  ? 5   DT  C N1    1 
ATOM   4607 C C2    . DT  B 2 5   ? 109.068 128.310 120.469 0.50 70.19  ? 5   DT  C C2    1 
ATOM   4608 O O2    . DT  B 2 5   ? 108.827 127.782 121.554 0.50 64.18  ? 5   DT  C O2    1 
ATOM   4609 N N3    . DT  B 2 5   ? 108.286 128.128 119.360 0.50 75.18  ? 5   DT  C N3    1 
ATOM   4610 C C4    . DT  B 2 5   ? 108.474 128.681 118.116 0.50 76.43  ? 5   DT  C C4    1 
ATOM   4611 O O4    . DT  B 2 5   ? 107.716 128.406 117.189 0.50 94.88  ? 5   DT  C O4    1 
ATOM   4612 C C5    . DT  B 2 5   ? 109.582 129.581 118.013 0.50 76.46  ? 5   DT  C C5    1 
ATOM   4613 C C7    . DT  B 2 5   ? 109.836 130.215 116.681 0.50 111.85 ? 5   DT  C C7    1 
ATOM   4614 C C6    . DT  B 2 5   ? 110.339 129.790 119.093 0.50 73.18  ? 5   DT  C C6    1 
ATOM   4615 P P     . DT  B 2 6   ? 113.919 128.116 124.254 0.50 92.02  ? 6   DT  C P     1 
ATOM   4616 O OP1   . DT  B 2 6   ? 114.601 128.220 125.579 0.50 85.05  ? 6   DT  C OP1   1 
ATOM   4617 O OP2   . DT  B 2 6   ? 114.740 127.721 123.074 0.50 85.84  ? 6   DT  C OP2   1 
ATOM   4618 O "O5'" . DT  B 2 6   ? 112.754 127.034 124.436 0.50 107.33 ? 6   DT  C "O5'" 1 
ATOM   4619 C "C5'" . DT  B 2 6   ? 111.472 127.487 124.968 0.50 100.32 ? 6   DT  C "C5'" 1 
ATOM   4620 C "C4'" . DT  B 2 6   ? 110.517 126.327 125.079 0.50 79.12  ? 6   DT  C "C4'" 1 
ATOM   4621 O "O4'" . DT  B 2 6   ? 109.862 126.153 123.801 0.50 70.88  ? 6   DT  C "O4'" 1 
ATOM   4622 C "C3'" . DT  B 2 6   ? 111.126 124.976 125.466 0.50 66.12  ? 6   DT  C "C3'" 1 
ATOM   4623 O "O3'" . DT  B 2 6   ? 110.364 124.342 126.494 0.50 64.09  ? 6   DT  C "O3'" 1 
ATOM   4624 C "C2'" . DT  B 2 6   ? 111.136 124.231 124.127 0.50 68.71  ? 6   DT  C "C2'" 1 
ATOM   4625 C "C1'" . DT  B 2 6   ? 109.956 124.802 123.366 0.50 62.01  ? 6   DT  C "C1'" 1 
ATOM   4626 N N1    . DT  B 2 6   ? 110.033 124.905 121.893 0.50 62.92  ? 6   DT  C N1    1 
ATOM   4627 C C2    . DT  B 2 6   ? 108.944 124.464 121.167 0.50 63.55  ? 6   DT  C C2    1 
ATOM   4628 O O2    . DT  B 2 6   ? 108.001 123.888 121.695 0.50 79.97  ? 6   DT  C O2    1 
ATOM   4629 N N3    . DT  B 2 6   ? 108.978 124.731 119.824 0.50 59.70  ? 6   DT  C N3    1 
ATOM   4630 C C4    . DT  B 2 6   ? 109.986 125.396 119.154 0.50 77.22  ? 6   DT  C C4    1 
ATOM   4631 O O4    . DT  B 2 6   ? 109.938 125.548 117.937 0.50 98.57  ? 6   DT  C O4    1 
ATOM   4632 C C5    . DT  B 2 6   ? 111.072 125.865 119.972 0.50 86.32  ? 6   DT  C C5    1 
ATOM   4633 C C7    . DT  B 2 6   ? 112.181 126.590 119.276 0.50 119.47 ? 6   DT  C C7    1 
ATOM   4634 C C6    . DT  B 2 6   ? 111.047 125.616 121.291 0.50 72.01  ? 6   DT  C C6    1 
ATOM   4635 P P     . DT  B 2 7   ? 110.626 122.807 126.919 0.50 88.55  ? 7   DT  C P     1 
ATOM   4636 O OP1   . DT  B 2 7   ? 110.891 122.695 128.380 0.50 86.03  ? 7   DT  C OP1   1 
ATOM   4637 O OP2   . DT  B 2 7   ? 111.664 122.248 126.010 0.50 110.67 ? 7   DT  C OP2   1 
ATOM   4638 O "O5'" . DT  B 2 7   ? 109.387 121.837 126.569 0.50 94.73  ? 7   DT  C "O5'" 1 
ATOM   4639 C "C5'" . DT  B 2 7   ? 108.096 122.394 126.213 0.50 95.31  ? 7   DT  C "C5'" 1 
ATOM   4640 C "C4'" . DT  B 2 7   ? 107.228 121.400 125.469 0.50 99.05  ? 7   DT  C "C4'" 1 
ATOM   4641 O "O4'" . DT  B 2 7   ? 107.348 121.600 124.038 0.50 88.68  ? 7   DT  C "O4'" 1 
ATOM   4642 C "C3'" . DT  B 2 7   ? 107.471 119.908 125.702 0.50 101.72 ? 7   DT  C "C3'" 1 
ATOM   4643 O "O3'" . DT  B 2 7   ? 106.190 119.257 125.710 0.50 122.52 ? 7   DT  C "O3'" 1 
ATOM   4644 C "C2'" . DT  B 2 7   ? 108.286 119.515 124.470 0.50 98.34  ? 7   DT  C "C2'" 1 
ATOM   4645 C "C1'" . DT  B 2 7   ? 107.669 120.374 123.381 0.50 77.20  ? 7   DT  C "C1'" 1 
ATOM   4646 N N1    . DT  B 2 7   ? 108.545 120.754 122.258 0.50 81.25  ? 7   DT  C N1    1 
ATOM   4647 C C2    . DT  B 2 7   ? 108.024 120.743 120.973 0.50 75.84  ? 7   DT  C C2    1 
ATOM   4648 O O2    . DT  B 2 7   ? 106.908 120.332 120.709 0.50 85.75  ? 7   DT  C O2    1 
ATOM   4649 N N3    . DT  B 2 7   ? 108.859 121.222 120.003 0.50 72.55  ? 7   DT  C N3    1 
ATOM   4650 C C4    . DT  B 2 7   ? 110.126 121.716 120.195 0.50 80.47  ? 7   DT  C C4    1 
ATOM   4651 O O4    . DT  B 2 7   ? 110.771 122.094 119.224 0.50 119.79 ? 7   DT  C O4    1 
ATOM   4652 C C5    . DT  B 2 7   ? 110.611 121.710 121.556 0.50 77.39  ? 7   DT  C C5    1 
ATOM   4653 C C7    . DT  B 2 7   ? 111.982 122.240 121.829 0.50 86.17  ? 7   DT  C C7    1 
ATOM   4654 C C6    . DT  B 2 7   ? 109.803 121.254 122.517 0.50 85.56  ? 7   DT  C C6    1 
ATOM   4655 P P     . DC  B 2 8   ? 105.908 117.778 126.303 0.50 126.64 ? 8   DC  C P     1 
ATOM   4656 O OP1   . DC  B 2 8   ? 105.212 117.941 127.610 0.50 144.62 ? 8   DC  C OP1   1 
ATOM   4657 O OP2   . DC  B 2 8   ? 107.106 116.885 126.252 0.50 116.01 ? 8   DC  C OP2   1 
ATOM   4658 O "O5'" . DC  B 2 8   ? 104.827 117.142 125.303 0.50 102.58 ? 8   DC  C "O5'" 1 
ATOM   4659 C "C5'" . DC  B 2 8   ? 104.468 117.864 124.091 0.50 119.78 ? 8   DC  C "C5'" 1 
ATOM   4660 C "C4'" . DC  B 2 8   ? 104.237 116.897 122.946 0.50 114.04 ? 8   DC  C "C4'" 1 
ATOM   4661 O "O4'" . DC  B 2 8   ? 105.028 117.276 121.790 0.50 101.13 ? 8   DC  C "O4'" 1 
ATOM   4662 C "C3'" . DC  B 2 8   ? 104.611 115.451 123.258 0.50 106.96 ? 8   DC  C "C3'" 1 
ATOM   4663 O "O3'" . DC  B 2 8   ? 103.695 114.622 122.528 0.50 127.07 ? 8   DC  C "O3'" 1 
ATOM   4664 C "C2'" . DC  B 2 8   ? 106.041 115.397 122.739 0.50 98.77  ? 8   DC  C "C2'" 1 
ATOM   4665 C "C1'" . DC  B 2 8   ? 105.939 116.238 121.474 0.50 96.28  ? 8   DC  C "C1'" 1 
ATOM   4666 N N1    . DC  B 2 8   ? 107.217 116.840 121.018 0.50 90.26  ? 8   DC  C N1    1 
ATOM   4667 C C2    . DC  B 2 8   ? 107.514 116.811 119.647 0.50 76.39  ? 8   DC  C C2    1 
ATOM   4668 O O2    . DC  B 2 8   ? 106.684 116.289 118.877 0.50 69.14  ? 8   DC  C O2    1 
ATOM   4669 N N3    . DC  B 2 8   ? 108.671 117.394 119.220 0.50 71.98  ? 8   DC  C N3    1 
ATOM   4670 C C4    . DC  B 2 8   ? 109.522 117.946 120.107 0.50 101.15 ? 8   DC  C C4    1 
ATOM   4671 N N4    . DC  B 2 8   ? 110.648 118.481 119.657 0.50 110.85 ? 8   DC  C N4    1 
ATOM   4672 C C5    . DC  B 2 8   ? 109.235 117.970 121.506 0.50 105.82 ? 8   DC  C C5    1 
ATOM   4673 C C6    . DC  B 2 8   ? 108.085 117.408 121.913 0.50 91.72  ? 8   DC  C C6    1 
ATOM   4674 P P     . DC  B 2 9   ? 103.449 113.048 122.807 0.50 122.16 ? 9   DC  C P     1 
ATOM   4675 O OP1   . DC  B 2 9   ? 101.998 112.855 123.093 0.50 132.29 ? 9   DC  C OP1   1 
ATOM   4676 O OP2   . DC  B 2 9   ? 104.428 112.437 123.756 0.50 116.45 ? 9   DC  C OP2   1 
ATOM   4677 O "O5'" . DC  B 2 9   ? 103.738 112.484 121.331 0.50 95.53  ? 9   DC  C "O5'" 1 
ATOM   4678 C "C5'" . DC  B 2 9   ? 103.256 113.255 120.187 0.50 93.60  ? 9   DC  C "C5'" 1 
ATOM   4679 C "C4'" . DC  B 2 9   ? 103.832 112.695 118.905 0.50 99.24  ? 9   DC  C "C4'" 1 
ATOM   4680 O "O4'" . DC  B 2 9   ? 105.031 113.422 118.551 0.50 102.36 ? 9   DC  C "O4'" 1 
ATOM   4681 C "C3'" . DC  B 2 9   ? 104.247 111.221 118.965 0.50 95.88  ? 9   DC  C "C3'" 1 
ATOM   4682 O "O3'" . DC  B 2 9   ? 104.162 110.652 117.654 0.50 97.88  ? 9   DC  C "O3'" 1 
ATOM   4683 C "C2'" . DC  B 2 9   ? 105.706 111.335 119.354 0.50 83.48  ? 9   DC  C "C2'" 1 
ATOM   4684 C "C1'" . DC  B 2 9   ? 106.109 112.510 118.473 0.50 95.03  ? 9   DC  C "C1'" 1 
ATOM   4685 N N1    . DC  B 2 9   ? 107.354 113.219 118.853 0.50 87.83  ? 9   DC  C N1    1 
ATOM   4686 C C2    . DC  B 2 9   ? 108.177 113.717 117.840 0.50 79.16  ? 9   DC  C C2    1 
ATOM   4687 O O2    . DC  B 2 9   ? 107.818 113.540 116.664 0.50 79.07  ? 9   DC  C O2    1 
ATOM   4688 N N3    . DC  B 2 9   ? 109.326 114.350 118.181 0.50 72.04  ? 9   DC  C N3    1 
ATOM   4689 C C4    . DC  B 2 9   ? 109.651 114.499 119.472 0.50 66.14  ? 9   DC  C C4    1 
ATOM   4690 N N4    . DC  B 2 9   ? 110.768 115.133 119.784 0.50 62.56  ? 9   DC  C N4    1 
ATOM   4691 C C5    . DC  B 2 9   ? 108.832 113.987 120.502 0.50 74.88  ? 9   DC  C C5    1 
ATOM   4692 C C6    . DC  B 2 9   ? 107.701 113.366 120.151 0.50 83.58  ? 9   DC  C C6    1 
ATOM   4693 P P     . DC  B 2 10  ? 104.005 109.068 117.381 0.50 95.99  ? 10  DC  C P     1 
ATOM   4694 O OP1   . DC  B 2 10  ? 102.532 108.841 117.439 0.50 118.59 ? 10  DC  C OP1   1 
ATOM   4695 O OP2   . DC  B 2 10  ? 104.883 108.227 118.258 0.50 66.10  ? 10  DC  C OP2   1 
ATOM   4696 O "O5'" . DC  B 2 10  ? 104.419 108.885 115.835 0.50 83.34  ? 10  DC  C "O5'" 1 
ATOM   4697 C "C5'" . DC  B 2 10  ? 104.195 109.995 114.896 0.50 92.04  ? 10  DC  C "C5'" 1 
ATOM   4698 C "C4'" . DC  B 2 10  ? 105.258 109.983 113.812 0.50 90.40  ? 10  DC  C "C4'" 1 
ATOM   4699 O "O4'" . DC  B 2 10  ? 106.476 110.679 114.212 0.50 90.82  ? 10  DC  C "O4'" 1 
ATOM   4700 C "C3'" . DC  B 2 10  ? 105.701 108.586 113.440 0.50 79.86  ? 10  DC  C "C3'" 1 
ATOM   4701 O "O3'" . DC  B 2 10  ? 106.001 108.708 112.063 0.50 88.88  ? 10  DC  C "O3'" 1 
ATOM   4702 C "C2'" . DC  B 2 10  ? 106.930 108.393 114.322 0.50 80.62  ? 10  DC  C "C2'" 1 
ATOM   4703 C "C1'" . DC  B 2 10  ? 107.567 109.775 114.300 0.50 78.52  ? 10  DC  C "C1'" 1 
ATOM   4704 N N1    . DC  B 2 10  ? 108.340 110.117 115.517 0.50 70.80  ? 10  DC  C N1    1 
ATOM   4705 C C2    . DC  B 2 10  ? 109.683 110.478 115.389 0.50 69.14  ? 10  DC  C C2    1 
ATOM   4706 O O2    . DC  B 2 10  ? 110.156 110.495 114.241 0.50 71.77  ? 10  DC  C O2    1 
ATOM   4707 N N3    . DC  B 2 10  ? 110.384 110.829 116.504 0.50 70.46  ? 10  DC  C N3    1 
ATOM   4708 C C4    . DC  B 2 10  ? 109.799 110.780 117.719 0.50 96.52  ? 10  DC  C C4    1 
ATOM   4709 N N4    . DC  B 2 10  ? 110.498 111.108 118.798 0.50 108.85 ? 10  DC  C N4    1 
ATOM   4710 C C5    . DC  B 2 10  ? 108.431 110.415 117.857 0.50 106.56 ? 10  DC  C C5    1 
ATOM   4711 C C6    . DC  B 2 10  ? 107.751 110.102 116.742 0.50 89.88  ? 10  DC  C C6    1 
ATOM   4712 P P     . DG  B 2 11  ? 105.819 107.490 111.037 0.50 103.66 ? 11  DG  C P     1 
ATOM   4713 O OP1   . DG  B 2 11  ? 105.149 108.045 109.824 0.50 113.30 ? 11  DG  C OP1   1 
ATOM   4714 O OP2   . DG  B 2 11  ? 105.143 106.379 111.770 0.50 121.12 ? 11  DG  C OP2   1 
ATOM   4715 O "O5'" . DG  B 2 11  ? 107.344 107.108 110.705 0.50 87.97  ? 11  DG  C "O5'" 1 
ATOM   4716 C "C5'" . DG  B 2 11  ? 108.167 108.119 110.075 0.50 84.97  ? 11  DG  C "C5'" 1 
ATOM   4717 C "C4'" . DG  B 2 11  ? 109.642 107.866 110.271 0.50 88.00  ? 11  DG  C "C4'" 1 
ATOM   4718 O "O4'" . DG  B 2 11  ? 110.059 108.251 111.603 0.50 100.47 ? 11  DG  C "O4'" 1 
ATOM   4719 C "C3'" . DG  B 2 11  ? 110.148 106.443 110.069 0.50 101.45 ? 11  DG  C "C3'" 1 
ATOM   4720 O "O3'" . DG  B 2 11  ? 111.354 106.555 109.332 0.50 109.04 ? 11  DG  C "O3'" 1 
ATOM   4721 C "C2'" . DG  B 2 11  ? 110.435 105.961 111.494 0.50 108.19 ? 11  DG  C "C2'" 1 
ATOM   4722 C "C1'" . DG  B 2 11  ? 110.924 107.243 112.134 0.50 98.69  ? 11  DG  C "C1'" 1 
ATOM   4723 N N9    . DG  B 2 11  ? 110.866 107.333 113.586 0.50 78.52  ? 11  DG  C N9    1 
ATOM   4724 C C8    . DG  B 2 11  ? 109.862 106.967 114.436 0.50 71.96  ? 11  DG  C C8    1 
ATOM   4725 N N7    . DG  B 2 11  ? 110.110 107.261 115.688 0.50 84.50  ? 11  DG  C N7    1 
ATOM   4726 C C5    . DG  B 2 11  ? 111.340 107.900 115.647 0.50 85.35  ? 11  DG  C C5    1 
ATOM   4727 C C6    . DG  B 2 11  ? 112.110 108.443 116.701 0.50 83.36  ? 11  DG  C C6    1 
ATOM   4728 O O6    . DG  B 2 11  ? 111.840 108.463 117.909 0.50 85.13  ? 11  DG  C O6    1 
ATOM   4729 N N1    . DG  B 2 11  ? 113.302 108.981 116.234 0.50 76.70  ? 11  DG  C N1    1 
ATOM   4730 C C2    . DG  B 2 11  ? 113.684 109.002 114.920 0.50 80.29  ? 11  DG  C C2    1 
ATOM   4731 N N2    . DG  B 2 11  ? 114.856 109.582 114.668 0.50 108.67 ? 11  DG  C N2    1 
ATOM   4732 N N3    . DG  B 2 11  ? 112.979 108.486 113.917 0.50 83.50  ? 11  DG  C N3    1 
ATOM   4733 C C4    . DG  B 2 11  ? 111.817 107.953 114.358 0.50 83.25  ? 11  DG  C C4    1 
ATOM   4734 P P     . DT  B 2 12  ? 111.746 105.550 108.145 0.50 117.84 ? 12  DT  C P     1 
ATOM   4735 O OP1   . DT  B 2 12  ? 111.194 106.213 106.928 0.50 121.27 ? 12  DT  C OP1   1 
ATOM   4736 O OP2   . DT  B 2 12  ? 111.309 104.168 108.497 0.50 122.54 ? 12  DT  C OP2   1 
ATOM   4737 O "O5'" . DT  B 2 12  ? 113.351 105.555 108.152 0.50 103.33 ? 12  DT  C "O5'" 1 
ATOM   4738 C "C5'" . DT  B 2 12  ? 114.002 106.797 108.523 0.50 108.25 ? 12  DT  C "C5'" 1 
ATOM   4739 C "C4'" . DT  B 2 12  ? 115.202 106.570 109.416 0.50 92.36  ? 12  DT  C "C4'" 1 
ATOM   4740 O "O4'" . DT  B 2 12  ? 114.881 106.710 110.829 0.50 83.61  ? 12  DT  C "O4'" 1 
ATOM   4741 C "C3'" . DT  B 2 12  ? 115.936 105.249 109.244 0.50 84.70  ? 12  DT  C "C3'" 1 
ATOM   4742 O "O3'" . DT  B 2 12  ? 117.279 105.609 108.915 0.50 94.22  ? 12  DT  C "O3'" 1 
ATOM   4743 C "C2'" . DT  B 2 12  ? 115.720 104.563 110.598 0.50 84.47  ? 12  DT  C "C2'" 1 
ATOM   4744 C "C1'" . DT  B 2 12  ? 115.597 105.728 111.565 0.50 77.71  ? 12  DT  C "C1'" 1 
ATOM   4745 N N1    . DT  B 2 12  ? 114.855 105.456 112.803 0.50 76.79  ? 12  DT  C N1    1 
ATOM   4746 C C2    . DT  B 2 12  ? 115.424 105.793 114.015 0.50 61.93  ? 12  DT  C C2    1 
ATOM   4747 O O2    . DT  B 2 12  ? 116.526 106.297 114.114 0.50 49.30  ? 12  DT  C O2    1 
ATOM   4748 N N3    . DT  B 2 12  ? 114.640 105.541 115.107 0.50 65.61  ? 12  DT  C N3    1 
ATOM   4749 C C4    . DT  B 2 12  ? 113.382 104.970 115.093 0.50 91.22  ? 12  DT  C C4    1 
ATOM   4750 O O4    . DT  B 2 12  ? 112.797 104.793 116.161 0.50 105.10 ? 12  DT  C O4    1 
ATOM   4751 C C5    . DT  B 2 12  ? 112.844 104.646 113.786 0.50 95.93  ? 12  DT  C C5    1 
ATOM   4752 C C7    . DT  B 2 12  ? 111.479 104.036 113.664 0.50 108.76 ? 12  DT  C C7    1 
ATOM   4753 C C6    . DT  B 2 12  ? 113.593 104.921 112.719 0.50 91.75  ? 12  DT  C C6    1 
ATOM   4754 P P     . DA  B 2 13  ? 118.366 104.583 108.305 0.50 124.78 ? 13  DA  C P     1 
ATOM   4755 O OP1   . DA  B 2 13  ? 119.086 105.349 107.246 0.50 112.72 ? 13  DA  C OP1   1 
ATOM   4756 O OP2   . DA  B 2 13  ? 117.805 103.243 107.964 0.50 126.68 ? 13  DA  C OP2   1 
ATOM   4757 O "O5'" . DA  B 2 13  ? 119.374 104.369 109.533 0.50 114.25 ? 13  DA  C "O5'" 1 
ATOM   4758 C "C5'" . DA  B 2 13  ? 119.670 105.531 110.349 0.50 121.05 ? 13  DA  C "C5'" 1 
ATOM   4759 C "C4'" . DA  B 2 13  ? 120.331 105.126 111.641 0.50 125.49 ? 13  DA  C "C4'" 1 
ATOM   4760 O "O4'" . DA  B 2 13  ? 119.337 105.002 112.686 0.50 125.13 ? 13  DA  C "O4'" 1 
ATOM   4761 C "C3'" . DA  B 2 13  ? 121.099 103.809 111.614 0.50 126.35 ? 13  DA  C "C3'" 1 
ATOM   4762 O "O3'" . DA  B 2 13  ? 122.213 103.978 112.489 0.50 152.18 ? 13  DA  C "O3'" 1 
ATOM   4763 C "C2'" . DA  B 2 13  ? 120.085 102.845 112.217 0.50 123.85 ? 13  DA  C "C2'" 1 
ATOM   4764 C "C1'" . DA  B 2 13  ? 119.473 103.722 113.296 0.50 106.05 ? 13  DA  C "C1'" 1 
ATOM   4765 N N9    . DA  B 2 13  ? 118.181 103.271 113.790 0.50 100.11 ? 13  DA  C N9    1 
ATOM   4766 C C8    . DA  B 2 13  ? 117.137 102.717 113.093 0.50 101.43 ? 13  DA  C C8    1 
ATOM   4767 N N7    . DA  B 2 13  ? 116.123 102.395 113.856 0.50 106.40 ? 13  DA  C N7    1 
ATOM   4768 C C5    . DA  B 2 13  ? 116.531 102.749 115.135 0.50 96.28  ? 13  DA  C C5    1 
ATOM   4769 C C6    . DA  B 2 13  ? 115.896 102.658 116.383 0.50 89.88  ? 13  DA  C C6    1 
ATOM   4770 N N6    . DA  B 2 13  ? 114.673 102.166 116.539 0.50 102.61 ? 13  DA  C N6    1 
ATOM   4771 N N1    . DA  B 2 13  ? 116.556 103.128 117.465 0.50 86.68  ? 13  DA  C N1    1 
ATOM   4772 C C2    . DA  B 2 13  ? 117.777 103.637 117.282 0.50 89.36  ? 13  DA  C C2    1 
ATOM   4773 N N3    . DA  B 2 13  ? 118.489 103.748 116.160 0.50 89.51  ? 13  DA  C N3    1 
ATOM   4774 C C4    . DA  B 2 13  ? 117.798 103.289 115.110 0.50 91.57  ? 13  DA  C C4    1 
ATOM   4775 P P     . DA  B 2 14  ? 123.619 103.209 112.342 0.50 148.89 ? 14  DA  C P     1 
ATOM   4776 O OP1   . DA  B 2 14  ? 124.461 104.125 111.518 0.50 145.37 ? 14  DA  C OP1   1 
ATOM   4777 O OP2   . DA  B 2 14  ? 123.460 101.784 111.925 0.50 131.86 ? 14  DA  C OP2   1 
ATOM   4778 O "O5'" . DA  B 2 14  ? 124.134 103.219 113.861 0.50 134.85 ? 14  DA  C "O5'" 1 
ATOM   4779 C "C5'" . DA  B 2 14  ? 123.889 104.407 114.672 0.50 139.27 ? 14  DA  C "C5'" 1 
ATOM   4780 C "C4'" . DA  B 2 14  ? 123.753 104.023 116.125 0.50 141.37 ? 14  DA  C "C4'" 1 
ATOM   4781 O "O4'" . DA  B 2 14  ? 122.398 103.588 116.382 0.50 145.03 ? 14  DA  C "O4'" 1 
ATOM   4782 C "C3'" . DA  B 2 14  ? 124.654 102.872 116.559 0.50 153.13 ? 14  DA  C "C3'" 1 
ATOM   4783 O "O3'" . DA  B 2 14  ? 124.921 103.074 117.947 0.50 176.07 ? 14  DA  C "O3'" 1 
ATOM   4784 C "C2'" . DA  B 2 14  ? 123.746 101.670 116.329 0.50 147.41 ? 14  DA  C "C2'" 1 
ATOM   4785 C "C1'" . DA  B 2 14  ? 122.428 102.237 116.838 0.50 139.81 ? 14  DA  C "C1'" 1 
ATOM   4786 N N9    . DA  B 2 14  ? 121.229 101.537 116.385 0.50 115.30 ? 14  DA  C N9    1 
ATOM   4787 C C8    . DA  B 2 14  ? 120.897 101.076 115.135 0.50 129.81 ? 14  DA  C C8    1 
ATOM   4788 N N7    . DA  B 2 14  ? 119.746 100.455 115.096 0.50 126.00 ? 14  DA  C N7    1 
ATOM   4789 C C5    . DA  B 2 14  ? 119.295 100.504 116.403 0.50 105.83 ? 14  DA  C C5    1 
ATOM   4790 C C6    . DA  B 2 14  ? 118.127 100.011 117.001 0.50 94.08  ? 14  DA  C C6    1 
ATOM   4791 N N6    . DA  B 2 14  ? 117.182 99.379  116.318 0.50 103.04 ? 14  DA  C N6    1 
ATOM   4792 N N1    . DA  B 2 14  ? 117.972 100.216 118.327 0.50 79.68  ? 14  DA  C N1    1 
ATOM   4793 C C2    . DA  B 2 14  ? 118.945 100.870 118.979 0.50 84.85  ? 14  DA  C C2    1 
ATOM   4794 N N3    . DA  B 2 14  ? 120.092 101.379 118.526 0.50 75.68  ? 14  DA  C N3    1 
ATOM   4795 C C4    . DA  B 2 14  ? 120.203 101.159 117.211 0.50 90.73  ? 14  DA  C C4    1 
ATOM   4796 P P     . DA  B 2 15  ? 126.294 102.637 118.668 0.50 183.12 ? 15  DA  C P     1 
ATOM   4797 O OP1   . DA  B 2 15  ? 127.194 103.825 118.708 0.50 192.41 ? 15  DA  C OP1   1 
ATOM   4798 O OP2   . DA  B 2 15  ? 126.833 101.344 118.147 0.50 161.10 ? 15  DA  C OP2   1 
ATOM   4799 O "O5'" . DA  B 2 15  ? 125.797 102.399 120.173 0.50 171.43 ? 15  DA  C "O5'" 1 
ATOM   4800 C "C5'" . DA  B 2 15  ? 124.562 103.020 120.618 0.50 156.17 ? 15  DA  C "C5'" 1 
ATOM   4801 C "C4'" . DA  B 2 15  ? 123.791 102.082 121.521 0.50 148.49 ? 15  DA  C "C4'" 1 
ATOM   4802 O "O4'" . DA  B 2 15  ? 122.762 101.384 120.777 0.50 136.59 ? 15  DA  C "O4'" 1 
ATOM   4803 C "C3'" . DA  B 2 15  ? 124.611 101.004 122.223 0.50 159.33 ? 15  DA  C "C3'" 1 
ATOM   4804 O "O3'" . DA  B 2 15  ? 124.093 100.949 123.543 0.50 158.98 ? 15  DA  C "O3'" 1 
ATOM   4805 C "C2'" . DA  B 2 15  ? 124.307 99.743  121.413 0.50 159.10 ? 15  DA  C "C2'" 1 
ATOM   4806 C "C1'" . DA  B 2 15  ? 122.859 99.981  121.025 0.50 126.42 ? 15  DA  C "C1'" 1 
ATOM   4807 N N9    . DA  B 2 15  ? 122.381 99.258  119.847 0.50 109.49 ? 15  DA  C N9    1 
ATOM   4808 C C8    . DA  B 2 15  ? 122.905 99.010  118.599 0.50 107.20 ? 15  DA  C C8    1 
ATOM   4809 N N7    . DA  B 2 15  ? 122.122 98.290  117.829 0.50 97.09  ? 15  DA  C N7    1 
ATOM   4810 C C5    . DA  B 2 15  ? 121.007 98.051  118.621 0.50 100.92 ? 15  DA  C C5    1 
ATOM   4811 C C6    . DA  B 2 15  ? 119.818 97.345  118.384 0.50 87.73  ? 15  DA  C C6    1 
ATOM   4812 N N6    . DA  B 2 15  ? 119.535 96.745  117.234 0.50 103.94 ? 15  DA  C N6    1 
ATOM   4813 N N1    . DA  B 2 15  ? 118.910 97.313  119.381 0.50 79.77  ? 15  DA  C N1    1 
ATOM   4814 C C2    . DA  B 2 15  ? 119.206 97.917  120.541 0.50 86.89  ? 15  DA  C C2    1 
ATOM   4815 N N3    . DA  B 2 15  ? 120.295 98.592  120.895 0.50 88.36  ? 15  DA  C N3    1 
ATOM   4816 C C4    . DA  B 2 15  ? 121.160 98.632  119.869 0.50 106.29 ? 15  DA  C C4    1 
ATOM   4817 P P     . DT  B 2 16  ? 124.938 100.375 124.780 0.50 156.14 ? 16  DT  C P     1 
ATOM   4818 O OP1   . DT  B 2 16  ? 124.893 101.369 125.896 0.50 112.61 ? 16  DT  C OP1   1 
ATOM   4819 O OP2   . DT  B 2 16  ? 126.236 99.779  124.346 0.50 158.58 ? 16  DT  C OP2   1 
ATOM   4820 O "O5'" . DT  B 2 16  ? 123.950 99.180  125.157 0.50 144.87 ? 16  DT  C "O5'" 1 
ATOM   4821 C "C5'" . DT  B 2 16  ? 122.565 99.525  125.360 0.50 132.31 ? 16  DT  C "C5'" 1 
ATOM   4822 C "C4'" . DT  B 2 16  ? 121.728 98.278  125.452 0.50 106.24 ? 16  DT  C "C4'" 1 
ATOM   4823 O "O4'" . DT  B 2 16  ? 121.441 97.774  124.130 0.50 97.04  ? 16  DT  C "O4'" 1 
ATOM   4824 C "C3'" . DT  B 2 16  ? 122.360 97.131  126.222 0.50 108.96 ? 16  DT  C "C3'" 1 
ATOM   4825 O "O3'" . DT  B 2 16  ? 121.393 96.583  127.084 0.50 111.57 ? 16  DT  C "O3'" 1 
ATOM   4826 C "C2'" . DT  B 2 16  ? 122.767 96.144  125.139 0.50 113.16 ? 16  DT  C "C2'" 1 
ATOM   4827 C "C1'" . DT  B 2 16  ? 121.674 96.375  124.119 0.50 96.48  ? 16  DT  C "C1'" 1 
ATOM   4828 N N1    . DT  B 2 16  ? 121.965 95.995  122.730 0.50 88.31  ? 16  DT  C N1    1 
ATOM   4829 C C2    . DT  B 2 16  ? 120.970 95.326  122.072 0.50 82.52  ? 16  DT  C C2    1 
ATOM   4830 O O2    . DT  B 2 16  ? 119.912 95.048  122.617 0.50 87.15  ? 16  DT  C O2    1 
ATOM   4831 N N3    . DT  B 2 16  ? 121.233 95.011  120.768 0.50 83.78  ? 16  DT  C N3    1 
ATOM   4832 C C4    . DT  B 2 16  ? 122.391 95.282  120.078 0.50 111.96 ? 16  DT  C C4    1 
ATOM   4833 O O4    . DT  B 2 16  ? 122.485 94.929  118.899 0.50 126.20 ? 16  DT  C O4    1 
ATOM   4834 C C5    . DT  B 2 16  ? 123.410 95.981  120.832 0.50 131.09 ? 16  DT  C C5    1 
ATOM   4835 C C7    . DT  B 2 16  ? 124.700 96.326  120.145 0.50 175.78 ? 16  DT  C C7    1 
ATOM   4836 C C6    . DT  B 2 16  ? 123.142 96.325  122.103 0.50 107.75 ? 16  DT  C C6    1 
ATOM   4837 P P     . DG  B 2 17  ? 121.717 96.488  128.646 0.50 129.48 ? 17  DG  C P     1 
ATOM   4838 O OP1   . DG  B 2 17  ? 120.881 97.554  129.272 0.50 93.47  ? 17  DG  C OP1   1 
ATOM   4839 O OP2   . DG  B 2 17  ? 123.195 96.532  128.841 0.50 155.05 ? 17  DG  C OP2   1 
ATOM   4840 O "O5'" . DG  B 2 17  ? 121.216 94.979  128.835 0.50 152.22 ? 17  DG  C "O5'" 1 
ATOM   4841 C "C5'" . DG  B 2 17  ? 119.891 94.666  128.360 0.50 178.83 ? 17  DG  C "C5'" 1 
ATOM   4842 C "C4'" . DG  B 2 17  ? 119.796 93.239  127.877 0.50 188.25 ? 17  DG  C "C4'" 1 
ATOM   4843 O "O4'" . DG  B 2 17  ? 120.082 93.176  126.459 0.50 163.38 ? 17  DG  C "O4'" 1 
ATOM   4844 C "C3'" . DG  B 2 17  ? 120.699 92.199  128.554 0.50 180.15 ? 17  DG  C "C3'" 1 
ATOM   4845 O "O3'" . DG  B 2 17  ? 119.875 91.047  128.760 0.50 209.98 ? 17  DG  C "O3'" 1 
ATOM   4846 C "C2'" . DG  B 2 17  ? 121.779 91.963  127.500 0.50 143.96 ? 17  DG  C "C2'" 1 
ATOM   4847 C "C1'" . DG  B 2 17  ? 120.951 92.072  126.229 0.50 131.52 ? 17  DG  C "C1'" 1 
ATOM   4848 N N9    . DG  B 2 17  ? 121.676 92.277  124.985 0.50 93.15  ? 17  DG  C N9    1 
ATOM   4849 C C8    . DG  B 2 17  ? 122.817 93.009  124.815 0.50 91.07  ? 17  DG  C C8    1 
ATOM   4850 N N7    . DG  B 2 17  ? 123.236 93.024  123.571 0.50 88.95  ? 17  DG  C N7    1 
ATOM   4851 C C5    . DG  B 2 17  ? 122.314 92.251  122.877 0.50 77.91  ? 17  DG  C C5    1 
ATOM   4852 C C6    . DG  B 2 17  ? 122.264 91.909  121.501 0.50 66.24  ? 17  DG  C C6    1 
ATOM   4853 O O6    . DG  B 2 17  ? 123.050 92.229  120.603 0.50 81.18  ? 17  DG  C O6    1 
ATOM   4854 N N1    . DG  B 2 17  ? 121.156 91.132  121.206 0.50 67.26  ? 17  DG  C N1    1 
ATOM   4855 C C2    . DG  B 2 17  ? 120.235 90.708  122.131 0.50 85.99  ? 17  DG  C C2    1 
ATOM   4856 N N2    . DG  B 2 17  ? 119.240 89.943  121.659 0.50 100.86 ? 17  DG  C N2    1 
ATOM   4857 N N3    . DG  B 2 17  ? 120.275 91.018  123.433 0.50 82.07  ? 17  DG  C N3    1 
ATOM   4858 C C4    . DG  B 2 17  ? 121.347 91.785  123.740 0.50 82.39  ? 17  DG  C C4    1 
ATOM   4859 P P     . DC  B 2 18  ? 120.334 89.692  129.507 0.50 184.38 ? 18  DC  C P     1 
ATOM   4860 O OP1   . DC  B 2 18  ? 120.405 90.006  130.963 0.50 201.33 ? 18  DC  C OP1   1 
ATOM   4861 O OP2   . DC  B 2 18  ? 121.475 88.961  128.873 0.50 117.70 ? 18  DC  C OP2   1 
ATOM   4862 O "O5'" . DC  B 2 18  ? 119.036 88.782  129.256 0.50 160.41 ? 18  DC  C "O5'" 1 
ATOM   4863 C "C5'" . DC  B 2 18  ? 118.073 89.159  128.224 0.50 168.61 ? 18  DC  C "C5'" 1 
ATOM   4864 C "C4'" . DC  B 2 18  ? 117.903 88.013  127.257 0.50 181.60 ? 18  DC  C "C4'" 1 
ATOM   4865 O "O4'" . DC  B 2 18  ? 118.745 88.221  126.099 0.50 203.70 ? 18  DC  C "O4'" 1 
ATOM   4866 C "C3'" . DC  B 2 18  ? 118.312 86.649  127.802 0.50 190.13 ? 18  DC  C "C3'" 1 
ATOM   4867 O "O3'" . DC  B 2 18  ? 117.609 85.597  127.145 0.50 175.24 ? 18  DC  C "O3'" 1 
ATOM   4868 C "C2'" . DC  B 2 18  ? 119.789 86.605  127.433 0.50 188.64 ? 18  DC  C "C2'" 1 
ATOM   4869 C "C1'" . DC  B 2 18  ? 119.764 87.236  126.051 0.50 187.47 ? 18  DC  C "C1'" 1 
ATOM   4870 N N1    . DC  B 2 18  ? 121.008 87.919  125.617 0.50 140.75 ? 18  DC  C N1    1 
ATOM   4871 C C2    . DC  B 2 18  ? 121.328 87.888  124.257 0.50 130.18 ? 18  DC  C C2    1 
ATOM   4872 O O2    . DC  B 2 18  ? 120.590 87.252  123.488 0.50 151.08 ? 18  DC  C O2    1 
ATOM   4873 N N3    . DC  B 2 18  ? 122.440 88.531  123.822 0.50 125.24 ? 18  DC  C N3    1 
ATOM   4874 C C4    . DC  B 2 18  ? 123.197 89.227  124.683 0.50 120.18 ? 18  DC  C C4    1 
ATOM   4875 N N4    . DC  B 2 18  ? 124.276 89.827  124.199 0.50 106.16 ? 18  DC  C N4    1 
ATOM   4876 C C5    . DC  B 2 18  ? 122.877 89.281  126.074 0.50 115.90 ? 18  DC  C C5    1 
ATOM   4877 C C6    . DC  B 2 18  ? 121.785 88.616  126.494 0.50 120.57 ? 18  DC  C C6    1 
ATOM   4878 P P     . DT  C 3 1   ? 131.596 85.406  117.508 0.50 618.62 ? 1   DT  B P     1 
ATOM   4879 O OP1   . DT  C 3 1   ? 132.737 84.497  117.088 0.50 620.00 ? 1   DT  B OP1   1 
ATOM   4880 O OP2   . DT  C 3 1   ? 131.940 86.880  117.389 0.50 612.00 ? 1   DT  B OP2   1 
ATOM   4881 O "O5'" . DT  C 3 1   ? 130.401 85.141  116.452 0.50 620.00 ? 1   DT  B "O5'" 1 
ATOM   4882 C "C5'" . DT  C 3 1   ? 129.820 83.814  116.375 0.50 620.00 ? 1   DT  B "C5'" 1 
ATOM   4883 C "C4'" . DT  C 3 1   ? 128.335 83.919  116.122 0.50 596.93 ? 1   DT  B "C4'" 1 
ATOM   4884 O "O4'" . DT  C 3 1   ? 127.623 83.927  117.382 0.50 563.61 ? 1   DT  B "O4'" 1 
ATOM   4885 C "C3'" . DT  C 3 1   ? 127.878 85.169  115.371 0.50 558.98 ? 1   DT  B "C3'" 1 
ATOM   4886 O "O3'" . DT  C 3 1   ? 126.799 84.807  114.518 0.50 511.36 ? 1   DT  B "O3'" 1 
ATOM   4887 C "C2'" . DT  C 3 1   ? 127.400 86.083  116.489 0.50 532.49 ? 1   DT  B "C2'" 1 
ATOM   4888 C "C1'" . DT  C 3 1   ? 126.795 85.081  117.459 0.50 523.13 ? 1   DT  B "C1'" 1 
ATOM   4889 N N1    . DT  C 3 1   ? 126.748 85.511  118.872 0.50 496.73 ? 1   DT  B N1    1 
ATOM   4890 C C2    . DT  C 3 1   ? 125.669 85.102  119.628 0.50 487.77 ? 1   DT  B C2    1 
ATOM   4891 O O2    . DT  C 3 1   ? 124.765 84.411  119.177 0.50 468.60 ? 1   DT  B O2    1 
ATOM   4892 N N3    . DT  C 3 1   ? 125.684 85.529  120.932 0.50 502.02 ? 1   DT  B N3    1 
ATOM   4893 C C4    . DT  C 3 1   ? 126.651 86.307  121.544 0.50 512.07 ? 1   DT  B C4    1 
ATOM   4894 O O4    . DT  C 3 1   ? 126.528 86.614  122.733 0.50 498.10 ? 1   DT  B O4    1 
ATOM   4895 C C5    . DT  C 3 1   ? 127.754 86.698  120.695 0.50 516.82 ? 1   DT  B C5    1 
ATOM   4896 C C7    . DT  C 3 1   ? 128.846 87.545  121.280 0.50 522.98 ? 1   DT  B C7    1 
ATOM   4897 C C6    . DT  C 3 1   ? 127.752 86.287  119.415 0.50 496.17 ? 1   DT  B C6    1 
ATOM   4898 P P     . DG  C 3 2   ? 126.351 85.724  113.277 0.50 459.20 ? 2   DG  B P     1 
ATOM   4899 O OP1   . DG  C 3 2   ? 126.876 85.143  112.008 0.50 458.34 ? 2   DG  B OP1   1 
ATOM   4900 O OP2   . DG  C 3 2   ? 126.639 87.157  113.574 0.50 459.08 ? 2   DG  B OP2   1 
ATOM   4901 O "O5'" . DG  C 3 2   ? 124.765 85.509  113.310 0.50 372.28 ? 2   DG  B "O5'" 1 
ATOM   4902 C "C5'" . DG  C 3 2   ? 124.195 84.558  114.251 0.50 287.49 ? 2   DG  B "C5'" 1 
ATOM   4903 C "C4'" . DG  C 3 2   ? 122.789 84.980  114.617 0.50 236.67 ? 2   DG  B "C4'" 1 
ATOM   4904 O "O4'" . DG  C 3 2   ? 122.780 85.501  115.964 0.50 192.12 ? 2   DG  B "O4'" 1 
ATOM   4905 C "C3'" . DG  C 3 2   ? 122.175 86.070  113.735 0.50 223.59 ? 2   DG  B "C3'" 1 
ATOM   4906 O "O3'" . DG  C 3 2   ? 120.783 85.794  113.601 0.50 223.89 ? 2   DG  B "O3'" 1 
ATOM   4907 C "C2'" . DG  C 3 2   ? 122.447 87.342  114.537 0.50 175.80 ? 2   DG  B "C2'" 1 
ATOM   4908 C "C1'" . DG  C 3 2   ? 122.284 86.838  115.960 0.50 159.74 ? 2   DG  B "C1'" 1 
ATOM   4909 N N9    . DG  C 3 2   ? 122.988 87.608  116.990 0.50 146.45 ? 2   DG  B N9    1 
ATOM   4910 C C8    . DG  C 3 2   ? 123.981 88.553  116.902 0.50 146.52 ? 2   DG  B C8    1 
ATOM   4911 N N7    . DG  C 3 2   ? 124.354 89.028  118.069 0.50 136.31 ? 2   DG  B N7    1 
ATOM   4912 C C5    . DG  C 3 2   ? 123.552 88.362  118.986 0.50 129.09 ? 2   DG  B C5    1 
ATOM   4913 C C6    . DG  C 3 2   ? 123.494 88.462  120.403 0.50 131.18 ? 2   DG  B C6    1 
ATOM   4914 O O6    . DG  C 3 2   ? 124.158 89.184  121.163 0.50 123.36 ? 2   DG  B O6    1 
ATOM   4915 N N1    . DG  C 3 2   ? 122.526 87.604  120.926 0.50 136.98 ? 2   DG  B N1    1 
ATOM   4916 C C2    . DG  C 3 2   ? 121.738 86.750  120.189 0.50 159.11 ? 2   DG  B C2    1 
ATOM   4917 N N2    . DG  C 3 2   ? 120.858 86.000  120.865 0.50 179.92 ? 2   DG  B N2    1 
ATOM   4918 N N3    . DG  C 3 2   ? 121.786 86.656  118.863 0.50 142.81 ? 2   DG  B N3    1 
ATOM   4919 C C4    . DG  C 3 2   ? 122.712 87.485  118.331 0.50 135.52 ? 2   DG  B C4    1 
ATOM   4920 P P     . DC  C 3 3   ? 119.871 86.402  112.421 0.50 211.13 ? 3   DC  B P     1 
ATOM   4921 O OP1   . DC  C 3 3   ? 119.516 85.353  111.421 0.50 174.52 ? 3   DC  B OP1   1 
ATOM   4922 O OP2   . DC  C 3 3   ? 120.407 87.704  111.927 0.50 194.63 ? 3   DC  B OP2   1 
ATOM   4923 O "O5'" . DC  C 3 3   ? 118.590 86.661  113.345 0.50 214.27 ? 3   DC  B "O5'" 1 
ATOM   4924 C "C5'" . DC  C 3 3   ? 118.425 85.824  114.526 0.50 205.06 ? 3   DC  B "C5'" 1 
ATOM   4925 C "C4'" . DC  C 3 3   ? 117.522 86.495  115.536 0.50 178.84 ? 3   DC  B "C4'" 1 
ATOM   4926 O "O4'" . DC  C 3 3   ? 118.317 87.213  116.510 0.50 153.74 ? 3   DC  B "O4'" 1 
ATOM   4927 C "C3'" . DC  C 3 3   ? 116.528 87.504  114.965 0.50 166.24 ? 3   DC  B "C3'" 1 
ATOM   4928 O "O3'" . DC  C 3 3   ? 115.320 87.383  115.713 0.50 182.11 ? 3   DC  B "O3'" 1 
ATOM   4929 C "C2'" . DC  C 3 3   ? 117.236 88.828  115.215 0.50 158.82 ? 3   DC  B "C2'" 1 
ATOM   4930 C "C1'" . DC  C 3 3   ? 117.915 88.566  116.547 0.50 132.00 ? 3   DC  B "C1'" 1 
ATOM   4931 N N1    . DC  C 3 3   ? 119.108 89.392  116.825 0.50 118.13 ? 3   DC  B N1    1 
ATOM   4932 C C2    . DC  C 3 3   ? 119.353 89.697  118.161 0.50 95.71  ? 3   DC  B C2    1 
ATOM   4933 O O2    . DC  C 3 3   ? 118.566 89.234  119.000 0.50 75.99  ? 3   DC  B O2    1 
ATOM   4934 N N3    . DC  C 3 3   ? 120.442 90.453  118.473 0.50 107.50 ? 3   DC  B N3    1 
ATOM   4935 C C4    . DC  C 3 3   ? 121.259 90.905  117.499 0.50 128.00 ? 3   DC  B C4    1 
ATOM   4936 N N4    . DC  C 3 3   ? 122.314 91.631  117.847 0.50 118.61 ? 3   DC  B N4    1 
ATOM   4937 C C5    . DC  C 3 3   ? 121.010 90.608  116.125 0.50 129.14 ? 3   DC  B C5    1 
ATOM   4938 C C6    . DC  C 3 3   ? 119.934 89.853  115.837 0.50 131.53 ? 3   DC  B C6    1 
ATOM   4939 P P     . DA  C 3 4   ? 113.905 87.976  115.221 0.50 176.56 ? 4   DA  B P     1 
ATOM   4940 O OP1   . DA  C 3 4   ? 112.937 86.870  114.956 0.50 145.55 ? 4   DA  B OP1   1 
ATOM   4941 O OP2   . DA  C 3 4   ? 114.125 88.990  114.151 0.50 174.55 ? 4   DA  B OP2   1 
ATOM   4942 O "O5'" . DA  C 3 4   ? 113.446 88.736  116.558 0.50 144.90 ? 4   DA  B "O5'" 1 
ATOM   4943 C "C5'" . DA  C 3 4   ? 113.635 88.067  117.839 0.50 124.51 ? 4   DA  B "C5'" 1 
ATOM   4944 C "C4'" . DA  C 3 4   ? 113.513 89.043  118.983 0.50 106.03 ? 4   DA  B "C4'" 1 
ATOM   4945 O "O4'" . DA  C 3 4   ? 114.776 89.710  119.202 0.50 109.80 ? 4   DA  B "O4'" 1 
ATOM   4946 C "C3'" . DA  C 3 4   ? 112.478 90.137  118.814 0.50 102.72 ? 4   DA  B "C3'" 1 
ATOM   4947 O "O3'" . DA  C 3 4   ? 111.836 90.247  120.078 0.50 109.83 ? 4   DA  B "O3'" 1 
ATOM   4948 C "C2'" . DA  C 3 4   ? 113.329 91.348  118.424 0.50 110.34 ? 4   DA  B "C2'" 1 
ATOM   4949 C "C1'" . DA  C 3 4   ? 114.626 91.125  119.174 0.50 91.08  ? 4   DA  B "C1'" 1 
ATOM   4950 N N9    . DA  C 3 4   ? 115.838 91.641  118.541 0.50 88.35  ? 4   DA  B N9    1 
ATOM   4951 C C8    . DA  C 3 4   ? 116.308 91.420  117.270 0.50 94.10  ? 4   DA  B C8    1 
ATOM   4952 N N7    . DA  C 3 4   ? 117.469 91.982  117.040 0.50 108.44 ? 4   DA  B N7    1 
ATOM   4953 C C5    . DA  C 3 4   ? 117.813 92.580  118.244 0.50 90.72  ? 4   DA  B C5    1 
ATOM   4954 C C6    . DA  C 3 4   ? 118.940 93.333  118.641 0.50 94.11  ? 4   DA  B C6    1 
ATOM   4955 N N6    . DA  C 3 4   ? 119.974 93.641  117.857 0.50 107.47 ? 4   DA  B N6    1 
ATOM   4956 N N1    . DA  C 3 4   ? 118.955 93.765  119.915 0.50 81.96  ? 4   DA  B N1    1 
ATOM   4957 C C2    . DA  C 3 4   ? 117.909 93.466  120.698 0.50 85.08  ? 4   DA  B C2    1 
ATOM   4958 N N3    . DA  C 3 4   ? 116.798 92.782  120.437 0.50 71.60  ? 4   DA  B N3    1 
ATOM   4959 C C4    . DA  C 3 4   ? 116.805 92.382  119.169 0.50 73.36  ? 4   DA  B C4    1 
ATOM   4960 P P     . DT  C 3 5   ? 110.331 90.794  120.248 0.50 100.95 ? 5   DT  B P     1 
ATOM   4961 O OP1   . DT  C 3 5   ? 109.479 89.988  121.170 0.50 86.65  ? 5   DT  B OP1   1 
ATOM   4962 O OP2   . DT  C 3 5   ? 109.770 91.178  118.923 0.50 131.63 ? 5   DT  B OP2   1 
ATOM   4963 O "O5'" . DT  C 3 5   ? 110.738 92.124  121.033 0.50 93.12  ? 5   DT  B "O5'" 1 
ATOM   4964 C "C5'" . DT  C 3 5   ? 111.656 91.963  122.137 0.50 87.04  ? 5   DT  B "C5'" 1 
ATOM   4965 C "C4'" . DT  C 3 5   ? 112.308 93.267  122.514 0.50 80.89  ? 5   DT  B "C4'" 1 
ATOM   4966 O "O4'" . DT  C 3 5   ? 113.424 93.558  121.638 0.50 84.88  ? 5   DT  B "O4'" 1 
ATOM   4967 C "C3'" . DT  C 3 5   ? 111.411 94.497  122.510 0.50 75.02  ? 5   DT  B "C3'" 1 
ATOM   4968 O "O3'" . DT  C 3 5   ? 111.429 95.077  123.809 0.50 69.00  ? 5   DT  B "O3'" 1 
ATOM   4969 C "C2'" . DT  C 3 5   ? 111.997 95.331  121.370 0.50 75.36  ? 5   DT  B "C2'" 1 
ATOM   4970 C "C1'" . DT  C 3 5   ? 113.459 94.959  121.425 0.50 73.88  ? 5   DT  B "C1'" 1 
ATOM   4971 N N1    . DT  C 3 5   ? 114.297 95.234  120.244 0.50 69.91  ? 5   DT  B N1    1 
ATOM   4972 C C2    . DT  C 3 5   ? 115.343 96.107  120.416 0.50 72.12  ? 5   DT  B C2    1 
ATOM   4973 O O2    . DT  C 3 5   ? 115.565 96.660  121.491 0.50 69.11  ? 5   DT  B O2    1 
ATOM   4974 N N3    . DT  C 3 5   ? 116.134 96.276  119.312 0.50 77.79  ? 5   DT  B N3    1 
ATOM   4975 C C4    . DT  C 3 5   ? 115.965 95.698  118.077 0.50 78.73  ? 5   DT  B C4    1 
ATOM   4976 O O4    . DT  C 3 5   ? 116.732 95.963  117.154 0.50 98.99  ? 5   DT  B O4    1 
ATOM   4977 C C5    . DT  C 3 5   ? 114.871 94.780  117.981 0.50 77.64  ? 5   DT  B C5    1 
ATOM   4978 C C7    . DT  C 3 5   ? 114.641 94.114  116.660 0.50 112.97 ? 5   DT  B C7    1 
ATOM   4979 C C6    . DT  C 3 5   ? 114.107 94.582  119.058 0.50 74.25  ? 5   DT  B C6    1 
ATOM   4980 P P     . DT  C 3 6   ? 110.482 96.337  124.151 0.50 89.20  ? 6   DT  B P     1 
ATOM   4981 O OP1   . DT  C 3 6   ? 109.773 96.268  125.465 0.50 81.75  ? 6   DT  B OP1   1 
ATOM   4982 O OP2   . DT  C 3 6   ? 109.696 96.752  122.955 0.50 82.24  ? 6   DT  B OP2   1 
ATOM   4983 O "O5'" . DT  C 3 6   ? 111.660 97.405  124.340 0.50 104.95 ? 6   DT  B "O5'" 1 
ATOM   4984 C "C5'" . DT  C 3 6   ? 112.930 96.937  124.883 0.50 99.74  ? 6   DT  B "C5'" 1 
ATOM   4985 C "C4'" . DT  C 3 6   ? 113.894 98.089  125.004 0.50 80.15  ? 6   DT  B "C4'" 1 
ATOM   4986 O "O4'" . DT  C 3 6   ? 114.561 98.261  123.733 0.50 71.62  ? 6   DT  B "O4'" 1 
ATOM   4987 C "C3'" . DT  C 3 6   ? 113.296 99.445  125.386 0.50 68.29  ? 6   DT  B "C3'" 1 
ATOM   4988 O "O3'" . DT  C 3 6   ? 114.092 100.062 126.398 0.50 67.75  ? 6   DT  B "O3'" 1 
ATOM   4989 C "C2'" . DT  C 3 6   ? 113.279 100.182 124.043 0.50 69.86  ? 6   DT  B "C2'" 1 
ATOM   4990 C "C1'" . DT  C 3 6   ? 114.462 99.609  123.289 0.50 62.67  ? 6   DT  B "C1'" 1 
ATOM   4991 N N1    . DT  C 3 6   ? 114.386 99.487  121.820 0.50 63.34  ? 6   DT  B N1    1 
ATOM   4992 C C2    . DT  C 3 6   ? 115.471 99.932  121.090 0.50 62.97  ? 6   DT  B C2    1 
ATOM   4993 O O2    . DT  C 3 6   ? 116.404 100.531 121.609 0.50 79.95  ? 6   DT  B O2    1 
ATOM   4994 N N3    . DT  C 3 6   ? 115.444 99.641  119.753 0.50 59.89  ? 6   DT  B N3    1 
ATOM   4995 C C4    . DT  C 3 6   ? 114.448 98.950  119.092 0.50 77.11  ? 6   DT  B C4    1 
ATOM   4996 O O4    . DT  C 3 6   ? 114.500 98.779  117.878 0.50 99.98  ? 6   DT  B O4    1 
ATOM   4997 C C5    . DT  C 3 6   ? 113.368 98.476  119.914 0.50 85.65  ? 6   DT  B C5    1 
ATOM   4998 C C7    . DT  C 3 6   ? 112.274 97.721  119.224 0.50 115.81 ? 6   DT  B C7    1 
ATOM   4999 C C6    . DT  C 3 6   ? 113.386 98.748  121.228 0.50 72.51  ? 6   DT  B C6    1 
ATOM   5000 P P     . DT  C 3 7   ? 113.822 101.567 126.910 0.50 91.32  ? 7   DT  B P     1 
ATOM   5001 O OP1   . DT  C 3 7   ? 113.701 101.562 128.394 0.50 92.53  ? 7   DT  B OP1   1 
ATOM   5002 O OP2   . DT  C 3 7   ? 112.683 102.150 126.149 0.50 113.20 ? 7   DT  B OP2   1 
ATOM   5003 O "O5'" . DT  C 3 7   ? 115.029 102.550 126.487 0.50 94.48  ? 7   DT  B "O5'" 1 
ATOM   5004 C "C5'" . DT  C 3 7   ? 116.330 101.999 126.154 0.50 92.57  ? 7   DT  B "C5'" 1 
ATOM   5005 C "C4'" . DT  C 3 7   ? 117.208 102.984 125.409 0.50 94.10  ? 7   DT  B "C4'" 1 
ATOM   5006 O "O4'" . DT  C 3 7   ? 117.072 102.801 123.976 0.50 82.72  ? 7   DT  B "O4'" 1 
ATOM   5007 C "C3'" . DT  C 3 7   ? 117.007 104.480 125.655 0.50 93.77  ? 7   DT  B "C3'" 1 
ATOM   5008 O "O3'" . DT  C 3 7   ? 118.306 105.098 125.658 0.50 108.10 ? 7   DT  B "O3'" 1 
ATOM   5009 C "C2'" . DT  C 3 7   ? 116.200 104.906 124.429 0.50 89.59  ? 7   DT  B "C2'" 1 
ATOM   5010 C "C1'" . DT  C 3 7   ? 116.793 104.044 123.332 0.50 70.65  ? 7   DT  B "C1'" 1 
ATOM   5011 N N1    . DT  C 3 7   ? 115.903 103.708 122.209 0.50 75.71  ? 7   DT  B N1    1 
ATOM   5012 C C2    . DT  C 3 7   ? 116.437 103.607 120.933 0.50 72.97  ? 7   DT  B C2    1 
ATOM   5013 O O2    . DT  C 3 7   ? 117.593 103.891 120.671 0.50 84.28  ? 7   DT  B O2    1 
ATOM   5014 N N3    . DT  C 3 7   ? 115.571 103.176 119.969 0.50 70.63  ? 7   DT  B N3    1 
ATOM   5015 C C4    . DT  C 3 7   ? 114.259 102.820 120.161 0.50 79.66  ? 7   DT  B C4    1 
ATOM   5016 O O4    . DT  C 3 7   ? 113.590 102.473 119.194 0.50 121.40 ? 7   DT  B O4    1 
ATOM   5017 C C5    . DT  C 3 7   ? 113.762 102.939 121.515 0.50 75.01  ? 7   DT  B C5    1 
ATOM   5018 C C7    . DT  C 3 7   ? 112.341 102.577 121.797 0.50 84.60  ? 7   DT  B C7    1 
ATOM   5019 C C6    . DT  C 3 7   ? 114.599 103.350 122.467 0.50 80.92  ? 7   DT  B C6    1 
ATOM   5020 P P     . DA  C 3 8   ? 118.643 106.547 126.294 0.50 107.81 ? 8   DA  B P     1 
ATOM   5021 O OP1   . DA  C 3 8   ? 119.362 106.310 127.577 0.50 126.93 ? 8   DA  B OP1   1 
ATOM   5022 O OP2   . DA  C 3 8   ? 117.476 107.483 126.301 0.50 102.11 ? 8   DA  B OP2   1 
ATOM   5023 O "O5'" . DA  C 3 8   ? 119.728 107.187 125.305 0.50 84.73  ? 8   DA  B "O5'" 1 
ATOM   5024 C "C5'" . DA  C 3 8   ? 120.059 106.484 124.078 0.50 99.75  ? 8   DA  B "C5'" 1 
ATOM   5025 C "C4'" . DA  C 3 8   ? 120.314 107.469 122.954 0.50 91.92  ? 8   DA  B "C4'" 1 
ATOM   5026 O "O4'" . DA  C 3 8   ? 119.515 107.124 121.796 0.50 76.62  ? 8   DA  B "O4'" 1 
ATOM   5027 C "C3'" . DA  C 3 8   ? 119.963 108.909 123.309 0.50 82.25  ? 8   DA  B "C3'" 1 
ATOM   5028 O "O3'" . DA  C 3 8   ? 120.854 109.736 122.544 0.50 102.46 ? 8   DA  B "O3'" 1 
ATOM   5029 C "C2'" . DA  C 3 8   ? 118.511 108.970 122.851 0.50 71.95  ? 8   DA  B "C2'" 1 
ATOM   5030 C "C1'" . DA  C 3 8   ? 118.573 108.170 121.556 0.50 71.35  ? 8   DA  B "C1'" 1 
ATOM   5031 N N9    . DA  C 3 8   ? 117.285 107.609 121.150 0.50 65.12  ? 8   DA  B N9    1 
ATOM   5032 C C8    . DA  C 3 8   ? 116.208 107.314 121.953 0.50 62.97  ? 8   DA  B C8    1 
ATOM   5033 N N7    . DA  C 3 8   ? 115.193 106.819 121.289 0.50 64.37  ? 8   DA  B N7    1 
ATOM   5034 C C5    . DA  C 3 8   ? 115.616 106.791 119.963 0.50 51.56  ? 8   DA  B C5    1 
ATOM   5035 C C6    . DA  C 3 8   ? 114.987 106.365 118.782 0.50 40.67  ? 8   DA  B C6    1 
ATOM   5036 N N6    . DA  C 3 8   ? 113.758 105.875 118.716 0.50 45.79  ? 8   DA  B N6    1 
ATOM   5037 N N1    . DA  C 3 8   ? 115.704 106.440 117.649 0.50 56.23  ? 8   DA  B N1    1 
ATOM   5038 C C2    . DA  C 3 8   ? 116.954 106.919 117.716 0.50 58.94  ? 8   DA  B C2    1 
ATOM   5039 N N3    . DA  C 3 8   ? 117.643 107.381 118.751 0.50 54.33  ? 8   DA  B N3    1 
ATOM   5040 C C4    . DA  C 3 8   ? 116.904 107.287 119.864 0.50 58.92  ? 8   DA  B C4    1 
ATOM   5041 P P     . DC  C 3 9   ? 121.110 111.311 122.806 0.50 105.29 ? 9   DC  B P     1 
ATOM   5042 O OP1   . DC  C 3 9   ? 122.576 111.499 123.008 0.50 117.18 ? 9   DC  B OP1   1 
ATOM   5043 O OP2   . DC  C 3 9   ? 120.190 111.928 123.810 0.50 100.37 ? 9   DC  B OP2   1 
ATOM   5044 O "O5'" . DC  C 3 9   ? 120.755 111.855 121.338 0.50 87.48  ? 9   DC  B "O5'" 1 
ATOM   5045 C "C5'" . DC  C 3 9   ? 121.235 111.092 120.187 0.50 88.71  ? 9   DC  B "C5'" 1 
ATOM   5046 C "C4'" . DC  C 3 9   ? 120.657 111.657 118.907 0.50 96.97  ? 9   DC  B "C4'" 1 
ATOM   5047 O "O4'" . DC  C 3 9   ? 119.444 110.949 118.562 0.50 100.93 ? 9   DC  B "O4'" 1 
ATOM   5048 C "C3'" . DC  C 3 9   ? 120.263 113.137 118.955 0.50 96.22  ? 9   DC  B "C3'" 1 
ATOM   5049 O "O3'" . DC  C 3 9   ? 120.352 113.686 117.637 0.50 96.73  ? 9   DC  B "O3'" 1 
ATOM   5050 C "C2'" . DC  C 3 9   ? 118.804 113.051 119.354 0.50 82.69  ? 9   DC  B "C2'" 1 
ATOM   5051 C "C1'" . DC  C 3 9   ? 118.383 111.880 118.477 0.50 94.89  ? 9   DC  B "C1'" 1 
ATOM   5052 N N1    . DC  C 3 9   ? 117.128 111.190 118.856 0.50 88.93  ? 9   DC  B N1    1 
ATOM   5053 C C2    . DC  C 3 9   ? 116.344 110.624 117.848 0.50 80.31  ? 9   DC  B C2    1 
ATOM   5054 O O2    . DC  C 3 9   ? 116.740 110.734 116.674 0.50 80.11  ? 9   DC  B O2    1 
ATOM   5055 N N3    . DC  C 3 9   ? 115.185 110.007 118.187 0.50 72.31  ? 9   DC  B N3    1 
ATOM   5056 C C4    . DC  C 3 9   ? 114.820 109.930 119.474 0.50 66.42  ? 9   DC  B C4    1 
ATOM   5057 N N4    . DC  C 3 9   ? 113.697 109.308 119.784 0.50 62.73  ? 9   DC  B N4    1 
ATOM   5058 C C5    . DC  C 3 9   ? 115.600 110.512 120.499 0.50 75.82  ? 9   DC  B C5    1 
ATOM   5059 C C6    . DC  C 3 9   ? 116.738 111.120 120.149 0.50 85.59  ? 9   DC  B C6    1 
ATOM   5060 P P     . DG  C 3 10  ? 120.484 115.270 117.350 0.50 96.77  ? 10  DG  B P     1 
ATOM   5061 O OP1   . DG  C 3 10  ? 121.951 115.535 117.398 0.50 117.86 ? 10  DG  B OP1   1 
ATOM   5062 O OP2   . DG  C 3 10  ? 119.588 116.102 118.218 0.50 67.85  ? 10  DG  B OP2   1 
ATOM   5063 O "O5'" . DG  C 3 10  ? 120.081 115.456 115.804 0.50 78.83  ? 10  DG  B "O5'" 1 
ATOM   5064 C "C5'" . DG  C 3 10  ? 120.262 114.339 114.868 0.50 81.63  ? 10  DG  B "C5'" 1 
ATOM   5065 C "C4'" . DG  C 3 10  ? 119.242 114.449 113.750 0.50 76.88  ? 10  DG  B "C4'" 1 
ATOM   5066 O "O4'" . DG  C 3 10  ? 117.981 113.788 114.065 0.50 78.30  ? 10  DG  B "O4'" 1 
ATOM   5067 C "C3'" . DG  C 3 10  ? 118.862 115.880 113.466 0.50 66.91  ? 10  DG  B "C3'" 1 
ATOM   5068 O "O3'" . DG  C 3 10  ? 118.512 115.753 112.105 0.50 73.85  ? 10  DG  B "O3'" 1 
ATOM   5069 C "C2'" . DG  C 3 10  ? 117.664 116.082 114.391 0.50 67.81  ? 10  DG  B "C2'" 1 
ATOM   5070 C "C1'" . DG  C 3 10  ? 116.932 114.754 114.228 0.50 68.39  ? 10  DG  B "C1'" 1 
ATOM   5071 N N9    . DG  C 3 10  ? 116.120 114.351 115.373 0.50 59.36  ? 10  DG  B N9    1 
ATOM   5072 C C8    . DG  C 3 10  ? 116.451 114.598 116.678 0.50 67.54  ? 10  DG  B C8    1 
ATOM   5073 N N7    . DG  C 3 10  ? 115.606 114.104 117.546 0.50 76.38  ? 10  DG  B N7    1 
ATOM   5074 C C5    . DG  C 3 10  ? 114.658 113.479 116.760 0.50 67.12  ? 10  DG  B C5    1 
ATOM   5075 C C6    . DG  C 3 10  ? 113.518 112.753 117.161 0.50 76.52  ? 10  DG  B C6    1 
ATOM   5076 O O6    . DG  C 3 10  ? 113.112 112.546 118.311 0.50 111.08 ? 10  DG  B O6    1 
ATOM   5077 N N1    . DG  C 3 10  ? 112.823 112.265 116.065 0.50 72.36  ? 10  DG  B N1    1 
ATOM   5078 C C2    . DG  C 3 10  ? 113.200 112.445 114.761 0.50 69.32  ? 10  DG  B C2    1 
ATOM   5079 N N2    . DG  C 3 10  ? 112.389 111.904 113.850 0.50 73.12  ? 10  DG  B N2    1 
ATOM   5080 N N3    . DG  C 3 10  ? 114.278 113.126 114.368 0.50 64.68  ? 10  DG  B N3    1 
ATOM   5081 C C4    . DG  C 3 10  ? 114.962 113.618 115.424 0.50 60.61  ? 10  DG  B C4    1 
ATOM   5082 P P     . DG  C 3 11  ? 118.735 116.930 111.047 0.50 89.22  ? 11  DG  B P     1 
ATOM   5083 O OP1   . DG  C 3 11  ? 119.422 116.297 109.882 0.50 96.46  ? 11  DG  B OP1   1 
ATOM   5084 O OP2   . DG  C 3 11  ? 119.433 118.035 111.769 0.50 102.59 ? 11  DG  B OP2   1 
ATOM   5085 O "O5'" . DG  C 3 11  ? 117.209 117.303 110.697 0.50 80.12  ? 11  DG  B "O5'" 1 
ATOM   5086 C "C5'" . DG  C 3 11  ? 116.382 116.265 110.111 0.50 80.56  ? 11  DG  B "C5'" 1 
ATOM   5087 C "C4'" . DG  C 3 11  ? 114.906 116.514 110.303 0.50 82.97  ? 11  DG  B "C4'" 1 
ATOM   5088 O "O4'" . DG  C 3 11  ? 114.483 116.135 111.634 0.50 94.95  ? 11  DG  B "O4'" 1 
ATOM   5089 C "C3'" . DG  C 3 11  ? 114.397 117.932 110.090 0.50 98.28  ? 11  DG  B "C3'" 1 
ATOM   5090 O "O3'" . DG  C 3 11  ? 113.202 117.795 109.344 0.50 106.68 ? 11  DG  B "O3'" 1 
ATOM   5091 C "C2'" . DG  C 3 11  ? 114.093 118.420 111.509 0.50 107.11 ? 11  DG  B "C2'" 1 
ATOM   5092 C "C1'" . DG  C 3 11  ? 113.604 117.139 112.151 0.50 96.83  ? 11  DG  B "C1'" 1 
ATOM   5093 N N9    . DG  C 3 11  ? 113.646 117.054 113.604 0.50 77.78  ? 11  DG  B N9    1 
ATOM   5094 C C8    . DG  C 3 11  ? 114.649 117.441 114.446 0.50 73.26  ? 11  DG  B C8    1 
ATOM   5095 N N7    . DG  C 3 11  ? 114.410 117.159 115.702 0.50 85.44  ? 11  DG  B N7    1 
ATOM   5096 C C5    . DG  C 3 11  ? 113.188 116.505 115.674 0.50 85.79  ? 11  DG  B C5    1 
ATOM   5097 C C6    . DG  C 3 11  ? 112.431 115.965 116.739 0.50 83.27  ? 11  DG  B C6    1 
ATOM   5098 O O6    . DG  C 3 11  ? 112.711 115.962 117.944 0.50 84.39  ? 11  DG  B O6    1 
ATOM   5099 N N1    . DG  C 3 11  ? 111.242 115.408 116.286 0.50 76.38  ? 11  DG  B N1    1 
ATOM   5100 C C2    . DG  C 3 11  ? 110.851 115.369 114.976 0.50 77.55  ? 11  DG  B C2    1 
ATOM   5101 N N2    . DG  C 3 11  ? 109.686 114.771 114.740 0.50 100.50 ? 11  DG  B N2    1 
ATOM   5102 N N3    . DG  C 3 11  ? 111.545 115.881 113.962 0.50 83.62  ? 11  DG  B N3    1 
ATOM   5103 C C4    . DG  C 3 11  ? 112.706 116.432 114.388 0.50 82.88  ? 11  DG  B C4    1 
ATOM   5104 P P     . DG  C 3 12  ? 112.833 118.755 108.117 0.50 121.44 ? 12  DG  B P     1 
ATOM   5105 O OP1   . DG  C 3 12  ? 113.345 118.002 106.934 0.50 118.03 ? 12  DG  B OP1   1 
ATOM   5106 O OP2   . DG  C 3 12  ? 113.345 120.129 108.389 0.50 132.70 ? 12  DG  B OP2   1 
ATOM   5107 O "O5'" . DG  C 3 12  ? 111.229 118.799 108.189 0.50 120.84 ? 12  DG  B "O5'" 1 
ATOM   5108 C "C5'" . DG  C 3 12  ? 110.544 117.584 108.600 0.50 134.99 ? 12  DG  B "C5'" 1 
ATOM   5109 C "C4'" . DG  C 3 12  ? 109.336 117.865 109.469 0.50 120.36 ? 12  DG  B "C4'" 1 
ATOM   5110 O "O4'" . DG  C 3 12  ? 109.660 117.765 110.881 0.50 106.33 ? 12  DG  B "O4'" 1 
ATOM   5111 C "C3'" . DG  C 3 12  ? 108.632 119.201 109.256 0.50 113.06 ? 12  DG  B "C3'" 1 
ATOM   5112 O "O3'" . DG  C 3 12  ? 107.251 118.895 109.060 0.50 129.06 ? 12  DG  B "O3'" 1 
ATOM   5113 C "C2'" . DG  C 3 12  ? 108.933 119.951 110.559 0.50 112.29 ? 12  DG  B "C2'" 1 
ATOM   5114 C "C1'" . DG  C 3 12  ? 109.022 118.831 111.581 0.50 98.16  ? 12  DG  B "C1'" 1 
ATOM   5115 N N9    . DG  C 3 12  ? 109.783 119.117 112.793 0.50 95.04  ? 12  DG  B N9    1 
ATOM   5116 C C8    . DG  C 3 12  ? 110.932 119.856 112.927 0.50 101.38 ? 12  DG  B C8    1 
ATOM   5117 N N7    . DG  C 3 12  ? 111.374 119.903 114.156 0.50 97.49  ? 12  DG  B N7    1 
ATOM   5118 C C5    . DG  C 3 12  ? 110.470 119.128 114.875 0.50 89.51  ? 12  DG  B C5    1 
ATOM   5119 C C6    . DG  C 3 12  ? 110.451 118.796 116.252 0.50 81.45  ? 12  DG  B C6    1 
ATOM   5120 O O6    . DG  C 3 12  ? 111.236 119.140 117.143 0.50 100.17 ? 12  DG  B O6    1 
ATOM   5121 N N1    . DG  C 3 12  ? 109.370 117.997 116.569 0.50 82.14  ? 12  DG  B N1    1 
ATOM   5122 C C2    . DG  C 3 12  ? 108.440 117.555 115.673 0.50 90.19  ? 12  DG  B C2    1 
ATOM   5123 N N2    . DG  C 3 12  ? 107.466 116.797 116.192 0.50 113.54 ? 12  DG  B N2    1 
ATOM   5124 N N3    . DG  C 3 12  ? 108.442 117.855 114.376 0.50 72.46  ? 12  DG  B N3    1 
ATOM   5125 C C4    . DG  C 3 12  ? 109.487 118.643 114.048 0.50 87.06  ? 12  DG  B C4    1 
ATOM   5126 P P     . DA  C 3 13  ? 106.194 119.891 108.359 0.50 157.54 ? 13  DA  B P     1 
ATOM   5127 O OP1   . DA  C 3 13  ? 105.556 119.122 107.252 0.50 145.51 ? 13  DA  B OP1   1 
ATOM   5128 O OP2   . DA  C 3 13  ? 106.762 121.238 108.060 0.50 159.72 ? 13  DA  B OP2   1 
ATOM   5129 O "O5'" . DA  C 3 13  ? 105.112 120.065 109.531 0.50 138.73 ? 13  DA  B "O5'" 1 
ATOM   5130 C "C5'" . DA  C 3 13  ? 104.811 118.894 110.334 0.50 138.66 ? 13  DA  B "C5'" 1 
ATOM   5131 C "C4'" . DA  C 3 13  ? 104.153 119.285 111.634 0.50 136.06 ? 13  DA  B "C4'" 1 
ATOM   5132 O "O4'" . DA  C 3 13  ? 105.149 119.402 112.678 0.50 132.78 ? 13  DA  B "O4'" 1 
ATOM   5133 C "C3'" . DA  C 3 13  ? 103.379 120.600 111.624 0.50 132.58 ? 13  DA  B "C3'" 1 
ATOM   5134 O "O3'" . DA  C 3 13  ? 102.267 120.421 112.499 0.50 154.77 ? 13  DA  B "O3'" 1 
ATOM   5135 C "C2'" . DA  C 3 13  ? 104.389 121.560 112.241 0.50 128.88 ? 13  DA  B "C2'" 1 
ATOM   5136 C "C1'" . DA  C 3 13  ? 104.998 120.670 113.310 0.50 111.23 ? 13  DA  B "C1'" 1 
ATOM   5137 N N9    . DA  C 3 13  ? 106.279 121.129 113.827 0.50 104.49 ? 13  DA  B N9    1 
ATOM   5138 C C8    . DA  C 3 13  ? 107.309 121.731 113.148 0.50 105.84 ? 13  DA  B C8    1 
ATOM   5139 N N7    . DA  C 3 13  ? 108.313 122.055 113.922 0.50 109.76 ? 13  DA  B N7    1 
ATOM   5140 C C5    . DA  C 3 13  ? 107.913 121.655 115.189 0.50 98.89  ? 13  DA  B C5    1 
ATOM   5141 C C6    . DA  C 3 13  ? 108.545 121.724 116.440 0.50 92.87  ? 13  DA  B C6    1 
ATOM   5142 N N6    . DA  C 3 13  ? 109.755 122.243 116.609 0.50 105.68 ? 13  DA  B N6    1 
ATOM   5143 N N1    . DA  C 3 13  ? 107.895 121.211 117.510 0.50 88.83  ? 13  DA  B N1    1 
ATOM   5144 C C2    . DA  C 3 13  ? 106.688 120.675 117.311 0.50 90.31  ? 13  DA  B C2    1 
ATOM   5145 N N3    . DA  C 3 13  ? 105.980 120.580 116.185 0.50 92.75  ? 13  DA  B N3    1 
ATOM   5146 C C4    . DA  C 3 13  ? 106.659 121.086 115.147 0.50 94.94  ? 13  DA  B C4    1 
ATOM   5147 P P     . DA  C 3 14  ? 100.846 121.161 112.343 0.50 145.30 ? 14  DA  B P     1 
ATOM   5148 O OP1   . DA  C 3 14  ? 100.031 120.218 111.521 0.50 137.39 ? 14  DA  B OP1   1 
ATOM   5149 O OP2   . DA  C 3 14  ? 100.971 122.588 111.919 0.50 128.49 ? 14  DA  B OP2   1 
ATOM   5150 O "O5'" . DA  C 3 14  ? 100.332 121.145 113.863 0.50 128.25 ? 14  DA  B "O5'" 1 
ATOM   5151 C "C5'" . DA  C 3 14  ? 100.557 119.942 114.659 0.50 128.02 ? 14  DA  B "C5'" 1 
ATOM   5152 C "C4'" . DA  C 3 14  ? 100.705 120.295 116.121 0.50 126.36 ? 14  DA  B "C4'" 1 
ATOM   5153 O "O4'" . DA  C 3 14  ? 102.061 120.724 116.380 0.50 130.51 ? 14  DA  B "O4'" 1 
ATOM   5154 C "C3'" . DA  C 3 14  ? 99.809  121.432 116.597 0.50 132.83 ? 14  DA  B "C3'" 1 
ATOM   5155 O "O3'" . DA  C 3 14  ? 99.581  121.182 117.986 0.50 141.26 ? 14  DA  B "O3'" 1 
ATOM   5156 C "C2'" . DA  C 3 14  ? 100.711 122.641 116.377 0.50 131.08 ? 14  DA  B "C2'" 1 
ATOM   5157 C "C1'" . DA  C 3 14  ? 102.035 122.065 116.866 0.50 125.04 ? 14  DA  B "C1'" 1 
ATOM   5158 N N9    . DA  C 3 14  ? 103.232 122.770 116.417 0.50 102.63 ? 14  DA  B N9    1 
ATOM   5159 C C8    . DA  C 3 14  ? 103.580 123.199 115.161 0.50 116.68 ? 14  DA  B C8    1 
ATOM   5160 N N7    . DA  C 3 14  ? 104.722 123.836 115.123 0.50 117.89 ? 14  DA  B N7    1 
ATOM   5161 C C5    . DA  C 3 14  ? 105.153 123.828 116.438 0.50 99.64  ? 14  DA  B C5    1 
ATOM   5162 C C6    . DA  C 3 14  ? 106.305 124.353 117.039 0.50 89.99  ? 14  DA  B C6    1 
ATOM   5163 N N6    . DA  C 3 14  ? 107.252 124.979 116.354 0.50 99.77  ? 14  DA  B N6    1 
ATOM   5164 N N1    . DA  C 3 14  ? 106.445 124.181 118.372 0.50 76.78  ? 14  DA  B N1    1 
ATOM   5165 C C2    . DA  C 3 14  ? 105.470 123.533 119.025 0.50 81.19  ? 14  DA  B C2    1 
ATOM   5166 N N3    . DA  C 3 14  ? 104.336 122.998 118.569 0.50 71.66  ? 14  DA  B N3    1 
ATOM   5167 C C4    . DA  C 3 14  ? 104.241 123.183 117.248 0.50 83.76  ? 14  DA  B C4    1 
ATOM   5168 P P     . DA  C 3 15  ? 98.197  121.497 118.748 0.50 134.02 ? 15  DA  B P     1 
ATOM   5169 O OP1   . DA  C 3 15  ? 97.463  120.209 118.894 0.50 135.66 ? 15  DA  B OP1   1 
ATOM   5170 O OP2   . DA  C 3 15  ? 97.481  122.693 118.205 0.50 122.56 ? 15  DA  B OP2   1 
ATOM   5171 O "O5'" . DA  C 3 15  ? 98.685  121.842 120.233 0.50 130.91 ? 15  DA  B "O5'" 1 
ATOM   5172 C "C5'" . DA  C 3 15  ? 99.922  121.265 120.709 0.50 127.85 ? 15  DA  B "C5'" 1 
ATOM   5173 C "C4'" . DA  C 3 15  ? 100.671 122.250 121.580 0.50 126.07 ? 15  DA  B "C4'" 1 
ATOM   5174 O "O4'" . DA  C 3 15  ? 101.683 122.951 120.815 0.50 118.96 ? 15  DA  B "O4'" 1 
ATOM   5175 C "C3'" . DA  C 3 15  ? 99.833  123.329 122.257 0.50 141.40 ? 15  DA  B "C3'" 1 
ATOM   5176 O "O3'" . DA  C 3 15  ? 100.360 123.410 123.572 0.50 152.85 ? 15  DA  B "O3'" 1 
ATOM   5177 C "C2'" . DA  C 3 15  ? 100.120 124.580 121.425 0.50 142.43 ? 15  DA  B "C2'" 1 
ATOM   5178 C "C1'" . DA  C 3 15  ? 101.572 124.355 121.048 0.50 110.88 ? 15  DA  B "C1'" 1 
ATOM   5179 N N9    . DA  C 3 15  ? 102.055 125.068 119.866 0.50 96.19  ? 15  DA  B N9    1 
ATOM   5180 C C8    . DA  C 3 15  ? 101.551 125.288 118.605 0.50 93.88  ? 15  DA  B C8    1 
ATOM   5181 N N7    . DA  C 3 15  ? 102.335 126.012 117.840 0.50 87.93  ? 15  DA  B N7    1 
ATOM   5182 C C5    . DA  C 3 15  ? 103.431 126.279 118.648 0.50 92.09  ? 15  DA  B C5    1 
ATOM   5183 C C6    . DA  C 3 15  ? 104.614 127.001 118.421 0.50 80.22  ? 15  DA  B C6    1 
ATOM   5184 N N6    . DA  C 3 15  ? 104.910 127.589 117.269 0.50 96.03  ? 15  DA  B N6    1 
ATOM   5185 N N1    . DA  C 3 15  ? 105.503 127.060 119.433 0.50 74.00  ? 15  DA  B N1    1 
ATOM   5186 C C2    . DA  C 3 15  ? 105.194 126.469 120.597 0.50 80.13  ? 15  DA  B C2    1 
ATOM   5187 N N3    . DA  C 3 15  ? 104.110 125.782 120.944 0.50 80.15  ? 15  DA  B N3    1 
ATOM   5188 C C4    . DA  C 3 15  ? 103.264 125.715 119.902 0.50 96.41  ? 15  DA  B C4    1 
ATOM   5189 P P     . DC  C 3 16  ? 99.498  123.914 124.829 0.50 161.40 ? 16  DC  B P     1 
ATOM   5190 O OP1   . DC  C 3 16  ? 99.596  122.896 125.918 0.50 113.29 ? 16  DC  B OP1   1 
ATOM   5191 O OP2   . DC  C 3 16  ? 98.165  124.436 124.405 0.50 173.66 ? 16  DC  B OP2   1 
ATOM   5192 O "O5'" . DC  C 3 16  ? 100.424 125.149 125.240 0.50 165.50 ? 16  DC  B "O5'" 1 
ATOM   5193 C "C5'" . DC  C 3 16  ? 101.829 124.879 125.449 0.50 164.72 ? 16  DC  B "C5'" 1 
ATOM   5194 C "C4'" . DC  C 3 16  ? 102.590 126.166 125.642 0.50 143.49 ? 16  DC  B "C4'" 1 
ATOM   5195 O "O4'" . DC  C 3 16  ? 103.012 126.682 124.361 0.50 122.38 ? 16  DC  B "O4'" 1 
ATOM   5196 C "C3'" . DC  C 3 16  ? 101.811 127.287 126.320 0.50 161.26 ? 16  DC  B "C3'" 1 
ATOM   5197 O "O3'" . DC  C 3 16  ? 102.651 127.969 127.234 0.50 191.97 ? 16  DC  B "O3'" 1 
ATOM   5198 C "C2'" . DC  C 3 16  ? 101.429 128.195 125.161 0.50 150.69 ? 16  DC  B "C2'" 1 
ATOM   5199 C "C1'" . DC  C 3 16  ? 102.640 128.038 124.262 0.50 114.28 ? 16  DC  B "C1'" 1 
ATOM   5200 N N1    . DC  C 3 16  ? 102.446 128.331 122.831 0.50 87.27  ? 16  DC  B N1    1 
ATOM   5201 C C2    . DC  C 3 16  ? 103.415 129.105 122.209 0.50 75.53  ? 16  DC  B C2    1 
ATOM   5202 O O2    . DC  C 3 16  ? 104.362 129.492 122.909 0.50 81.99  ? 16  DC  B O2    1 
ATOM   5203 N N3    . DC  C 3 16  ? 103.320 129.377 120.891 0.50 72.40  ? 16  DC  B N3    1 
ATOM   5204 C C4    . DC  C 3 16  ? 102.280 128.922 120.204 0.50 85.75  ? 16  DC  B C4    1 
ATOM   5205 N N4    . DC  C 3 16  ? 102.221 129.217 118.915 0.50 94.30  ? 16  DC  B N4    1 
ATOM   5206 C C5    . DC  C 3 16  ? 101.267 128.143 120.830 0.50 96.97  ? 16  DC  B C5    1 
ATOM   5207 C C6    . DC  C 3 16  ? 101.406 127.843 122.128 0.50 89.22  ? 16  DC  B C6    1 
ATOM   5208 P P     . DT  C 3 17  ? 102.144 128.283 128.724 0.50 255.59 ? 17  DT  B P     1 
ATOM   5209 O OP1   . DT  C 3 17  ? 102.638 127.208 129.632 0.50 247.71 ? 17  DT  B OP1   1 
ATOM   5210 O OP2   . DT  C 3 17  ? 100.691 128.619 128.724 0.50 270.00 ? 17  DT  B OP2   1 
ATOM   5211 O "O5'" . DT  C 3 17  ? 102.978 129.622 128.967 0.50 249.16 ? 17  DT  B "O5'" 1 
ATOM   5212 C "C5'" . DT  C 3 17  ? 104.277 129.710 128.348 0.50 253.63 ? 17  DT  B "C5'" 1 
ATOM   5213 C "C4'" . DT  C 3 17  ? 104.515 131.123 127.884 0.50 247.23 ? 17  DT  B "C4'" 1 
ATOM   5214 O "O4'" . DT  C 3 17  ? 104.240 131.237 126.468 0.50 210.82 ? 17  DT  B "O4'" 1 
ATOM   5215 C "C3'" . DT  C 3 17  ? 103.665 132.193 128.568 0.50 236.02 ? 17  DT  B "C3'" 1 
ATOM   5216 O "O3'" . DT  C 3 17  ? 104.529 133.316 128.723 0.50 279.72 ? 17  DT  B "O3'" 1 
ATOM   5217 C "C2'" . DT  C 3 17  ? 102.561 132.447 127.550 0.50 192.33 ? 17  DT  B "C2'" 1 
ATOM   5218 C "C1'" . DT  C 3 17  ? 103.359 132.333 126.262 0.50 173.08 ? 17  DT  B "C1'" 1 
ATOM   5219 N N1    . DT  C 3 17  ? 102.613 132.089 125.025 0.50 125.60 ? 17  DT  B N1    1 
ATOM   5220 C C2    . DT  C 3 17  ? 103.165 132.578 123.862 0.50 106.35 ? 17  DT  B C2    1 
ATOM   5221 O O2    . DT  C 3 17  ? 104.222 133.195 123.862 0.50 94.71  ? 17  DT  B O2    1 
ATOM   5222 N N3    . DT  C 3 17  ? 102.446 132.322 122.717 0.50 100.48 ? 17  DT  B N3    1 
ATOM   5223 C C4    . DT  C 3 17  ? 101.259 131.613 122.631 0.50 113.37 ? 17  DT  B C4    1 
ATOM   5224 O O4    . DT  C 3 17  ? 100.708 131.445 121.536 0.50 99.66  ? 17  DT  B O4    1 
ATOM   5225 C C5    . DT  C 3 17  ? 100.739 131.132 123.895 0.50 140.51 ? 17  DT  B C5    1 
ATOM   5226 C C7    . DT  C 3 17  ? 99.445  130.371 123.891 0.50 169.27 ? 17  DT  B C7    1 
ATOM   5227 C C6    . DT  C 3 17  ? 101.434 131.381 125.020 0.50 131.37 ? 17  DT  B C6    1 
ATOM   5228 P P     . DG  C 3 18  ? 104.167 134.613 129.604 0.50 274.24 ? 18  DG  B P     1 
ATOM   5229 O OP1   . DG  C 3 18  ? 104.180 134.223 131.044 0.50 275.71 ? 18  DG  B OP1   1 
ATOM   5230 O OP2   . DG  C 3 18  ? 102.982 135.347 129.068 0.50 208.89 ? 18  DG  B OP2   1 
ATOM   5231 O "O5'" . DG  C 3 18  ? 105.458 135.510 129.294 0.50 267.80 ? 18  DG  B "O5'" 1 
ATOM   5232 C "C5'" . DG  C 3 18  ? 106.367 135.111 128.224 0.50 273.75 ? 18  DG  B "C5'" 1 
ATOM   5233 C "C4'" . DG  C 3 18  ? 106.573 136.267 127.275 0.50 266.51 ? 18  DG  B "C4'" 1 
ATOM   5234 O "O4'" . DG  C 3 18  ? 105.712 136.098 126.129 0.50 269.20 ? 18  DG  B "O4'" 1 
ATOM   5235 C "C3'" . DG  C 3 18  ? 106.237 137.642 127.848 0.50 260.61 ? 18  DG  B "C3'" 1 
ATOM   5236 O "O3'" . DG  C 3 18  ? 107.024 138.655 127.229 0.50 256.01 ? 18  DG  B "O3'" 1 
ATOM   5237 C "C2'" . DG  C 3 18  ? 104.767 137.776 127.467 0.50 246.82 ? 18  DG  B "C2'" 1 
ATOM   5238 C "C1'" . DG  C 3 18  ? 104.782 137.179 126.072 0.50 238.74 ? 18  DG  B "C1'" 1 
ATOM   5239 N N9    . DG  C 3 18  ? 103.507 136.653 125.589 0.50 175.73 ? 18  DG  B N9    1 
ATOM   5240 C C8    . DG  C 3 18  ? 102.429 136.142 126.267 0.50 153.15 ? 18  DG  B C8    1 
ATOM   5241 N N7    . DG  C 3 18  ? 101.472 135.730 125.466 0.50 159.03 ? 18  DG  B N7    1 
ATOM   5242 C C5    . DG  C 3 18  ? 101.950 135.989 124.184 0.50 139.38 ? 18  DG  B C5    1 
ATOM   5243 C C6    . DG  C 3 18  ? 101.354 135.771 122.912 0.50 107.77 ? 18  DG  B C6    1 
ATOM   5244 O O6    . DG  C 3 18  ? 100.244 135.287 122.652 0.50 93.30  ? 18  DG  B O6    1 
ATOM   5245 N N1    . DG  C 3 18  ? 102.196 136.184 121.880 0.50 113.67 ? 18  DG  B N1    1 
ATOM   5246 C C2    . DG  C 3 18  ? 103.453 136.721 122.042 0.50 147.06 ? 18  DG  B C2    1 
ATOM   5247 N N2    . DG  C 3 18  ? 104.133 137.051 120.932 0.50 151.91 ? 18  DG  B N2    1 
ATOM   5248 N N3    . DG  C 3 18  ? 104.012 136.931 123.232 0.50 153.96 ? 18  DG  B N3    1 
ATOM   5249 C C4    . DG  C 3 18  ? 103.206 136.551 124.252 0.50 149.02 ? 18  DG  B C4    1 
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