data_8YWZ
# 
_entry.id   8YWZ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YWZ         pdb_00008ywz 10.2210/pdb8ywz/pdb 
WWPDB D_1300044755 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-09 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YWZ 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              rmsl_2040@163.com 
_pdbx_contact_author.name_first         Jian 
_pdbx_contact_author.name_last          Li 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9511-4219 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zou, X.F.'  1 ? 
'Wang, W.W.' 2 ? 
'Zhang, J.'  3 ? 
'Li, J.'     4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Commun Biol' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2399-3642 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            8 
_citation.language                  ? 
_citation.page_first                493 
_citation.page_last                 493 
_citation.title                     
'Inhibitory efficacy and structural insights of Bofutrelvir against SARS-CoV-2 M pro mutants and MERS-CoV M pro.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s42003-025-07929-9 
_citation.pdbx_database_id_PubMed   40133408 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wang, W.' 1 0009-0007-7332-8217 
primary 'Zhou, X.' 2 ?                   
primary 'Li, W.'   3 ?                   
primary 'Zeng, P.' 4 ?                   
primary 'Guo, L.'  5 ?                   
primary 'Wang, Q.' 6 0000-0002-0614-6903 
primary 'Li, J.'   7 0000-0001-9511-4219 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 32720.395 2   3.4.22.69 H163A ? ? 
2 non-polymer syn 
;~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide
;
452.546   1   ?         ?     ? ? 
3 water       nat water 18.015    341 ?         ?     ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLAGSCGSVGFNIDYDCVSFCYM
AHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVR
;
_entity_poly.pdbx_seq_one_letter_code_can   
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLAGSCGSVGFNIDYDCVSFCYM
AHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVR
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide
;
FHR 
3 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PHE n 
1 2   ARG n 
1 3   LYS n 
1 4   MET n 
1 5   ALA n 
1 6   PHE n 
1 7   PRO n 
1 8   SER n 
1 9   GLY n 
1 10  LYS n 
1 11  VAL n 
1 12  GLU n 
1 13  GLY n 
1 14  CYS n 
1 15  MET n 
1 16  VAL n 
1 17  GLN n 
1 18  VAL n 
1 19  THR n 
1 20  CYS n 
1 21  GLY n 
1 22  THR n 
1 23  THR n 
1 24  THR n 
1 25  LEU n 
1 26  ASN n 
1 27  GLY n 
1 28  LEU n 
1 29  TRP n 
1 30  LEU n 
1 31  ASP n 
1 32  ASP n 
1 33  VAL n 
1 34  VAL n 
1 35  TYR n 
1 36  CYS n 
1 37  PRO n 
1 38  ARG n 
1 39  HIS n 
1 40  VAL n 
1 41  ILE n 
1 42  CYS n 
1 43  THR n 
1 44  SER n 
1 45  GLU n 
1 46  ASP n 
1 47  MET n 
1 48  LEU n 
1 49  ASN n 
1 50  PRO n 
1 51  ASN n 
1 52  TYR n 
1 53  GLU n 
1 54  ASP n 
1 55  LEU n 
1 56  LEU n 
1 57  ILE n 
1 58  ARG n 
1 59  LYS n 
1 60  SER n 
1 61  ASN n 
1 62  HIS n 
1 63  ASN n 
1 64  PHE n 
1 65  LEU n 
1 66  VAL n 
1 67  GLN n 
1 68  ALA n 
1 69  GLY n 
1 70  ASN n 
1 71  VAL n 
1 72  GLN n 
1 73  LEU n 
1 74  ARG n 
1 75  VAL n 
1 76  ILE n 
1 77  GLY n 
1 78  HIS n 
1 79  SER n 
1 80  MET n 
1 81  GLN n 
1 82  ASN n 
1 83  CYS n 
1 84  VAL n 
1 85  LEU n 
1 86  LYS n 
1 87  LEU n 
1 88  LYS n 
1 89  VAL n 
1 90  ASP n 
1 91  THR n 
1 92  ALA n 
1 93  ASN n 
1 94  PRO n 
1 95  LYS n 
1 96  THR n 
1 97  PRO n 
1 98  LYS n 
1 99  TYR n 
1 100 LYS n 
1 101 PHE n 
1 102 VAL n 
1 103 ARG n 
1 104 ILE n 
1 105 GLN n 
1 106 PRO n 
1 107 GLY n 
1 108 GLN n 
1 109 THR n 
1 110 PHE n 
1 111 SER n 
1 112 VAL n 
1 113 LEU n 
1 114 ALA n 
1 115 CYS n 
1 116 TYR n 
1 117 ASN n 
1 118 GLY n 
1 119 SER n 
1 120 PRO n 
1 121 SER n 
1 122 GLY n 
1 123 VAL n 
1 124 TYR n 
1 125 GLN n 
1 126 CYS n 
1 127 ALA n 
1 128 MET n 
1 129 ARG n 
1 130 PRO n 
1 131 ASN n 
1 132 PHE n 
1 133 THR n 
1 134 ILE n 
1 135 LYS n 
1 136 GLY n 
1 137 SER n 
1 138 PHE n 
1 139 LEU n 
1 140 ALA n 
1 141 GLY n 
1 142 SER n 
1 143 CYS n 
1 144 GLY n 
1 145 SER n 
1 146 VAL n 
1 147 GLY n 
1 148 PHE n 
1 149 ASN n 
1 150 ILE n 
1 151 ASP n 
1 152 TYR n 
1 153 ASP n 
1 154 CYS n 
1 155 VAL n 
1 156 SER n 
1 157 PHE n 
1 158 CYS n 
1 159 TYR n 
1 160 MET n 
1 161 ALA n 
1 162 HIS n 
1 163 MET n 
1 164 GLU n 
1 165 LEU n 
1 166 PRO n 
1 167 THR n 
1 168 GLY n 
1 169 VAL n 
1 170 HIS n 
1 171 ALA n 
1 172 GLY n 
1 173 THR n 
1 174 ASP n 
1 175 LEU n 
1 176 GLU n 
1 177 GLY n 
1 178 ASN n 
1 179 PHE n 
1 180 TYR n 
1 181 GLY n 
1 182 PRO n 
1 183 PHE n 
1 184 VAL n 
1 185 ASP n 
1 186 ARG n 
1 187 GLN n 
1 188 THR n 
1 189 ALA n 
1 190 GLN n 
1 191 ALA n 
1 192 ALA n 
1 193 GLY n 
1 194 THR n 
1 195 ASP n 
1 196 THR n 
1 197 THR n 
1 198 ILE n 
1 199 THR n 
1 200 VAL n 
1 201 ASN n 
1 202 VAL n 
1 203 LEU n 
1 204 ALA n 
1 205 TRP n 
1 206 LEU n 
1 207 TYR n 
1 208 ALA n 
1 209 ALA n 
1 210 VAL n 
1 211 ILE n 
1 212 ASN n 
1 213 GLY n 
1 214 ASP n 
1 215 ARG n 
1 216 TRP n 
1 217 PHE n 
1 218 LEU n 
1 219 ASN n 
1 220 ARG n 
1 221 PHE n 
1 222 THR n 
1 223 THR n 
1 224 THR n 
1 225 LEU n 
1 226 ASN n 
1 227 ASP n 
1 228 PHE n 
1 229 ASN n 
1 230 LEU n 
1 231 VAL n 
1 232 ALA n 
1 233 MET n 
1 234 LYS n 
1 235 TYR n 
1 236 ASN n 
1 237 TYR n 
1 238 GLU n 
1 239 PRO n 
1 240 LEU n 
1 241 THR n 
1 242 GLN n 
1 243 ASP n 
1 244 HIS n 
1 245 VAL n 
1 246 ASP n 
1 247 ILE n 
1 248 LEU n 
1 249 GLY n 
1 250 PRO n 
1 251 LEU n 
1 252 SER n 
1 253 ALA n 
1 254 GLN n 
1 255 THR n 
1 256 GLY n 
1 257 ILE n 
1 258 ALA n 
1 259 VAL n 
1 260 LEU n 
1 261 ASP n 
1 262 MET n 
1 263 CYS n 
1 264 ALA n 
1 265 SER n 
1 266 LEU n 
1 267 LYS n 
1 268 GLU n 
1 269 LEU n 
1 270 LEU n 
1 271 GLN n 
1 272 ASN n 
1 273 GLY n 
1 274 MET n 
1 275 ASN n 
1 276 GLY n 
1 277 ARG n 
1 278 THR n 
1 279 ILE n 
1 280 LEU n 
1 281 GLY n 
1 282 SER n 
1 283 ALA n 
1 284 LEU n 
1 285 LEU n 
1 286 GLU n 
1 287 ASP n 
1 288 GLU n 
1 289 PHE n 
1 290 THR n 
1 291 PRO n 
1 292 PHE n 
1 293 ASP n 
1 294 VAL n 
1 295 VAL n 
1 296 ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   296 
_entity_src_gen.gene_src_common_name               '2019-nCoV, SARS-CoV-2' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
FHR peptide-like        . 
;~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide
;
? 'C25 H32 N4 O4'  452.546 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PHE 1   3   3   PHE PHE A . n 
A 1 2   ARG 2   4   4   ARG ARG A . n 
A 1 3   LYS 3   5   5   LYS LYS A . n 
A 1 4   MET 4   6   6   MET MET A . n 
A 1 5   ALA 5   7   7   ALA ALA A . n 
A 1 6   PHE 6   8   8   PHE PHE A . n 
A 1 7   PRO 7   9   9   PRO PRO A . n 
A 1 8   SER 8   10  10  SER SER A . n 
A 1 9   GLY 9   11  11  GLY GLY A . n 
A 1 10  LYS 10  12  12  LYS LYS A . n 
A 1 11  VAL 11  13  13  VAL VAL A . n 
A 1 12  GLU 12  14  14  GLU GLU A . n 
A 1 13  GLY 13  15  15  GLY GLY A . n 
A 1 14  CYS 14  16  16  CYS CYS A . n 
A 1 15  MET 15  17  17  MET MET A . n 
A 1 16  VAL 16  18  18  VAL VAL A . n 
A 1 17  GLN 17  19  19  GLN GLN A . n 
A 1 18  VAL 18  20  20  VAL VAL A . n 
A 1 19  THR 19  21  21  THR THR A . n 
A 1 20  CYS 20  22  22  CYS CYS A . n 
A 1 21  GLY 21  23  23  GLY GLY A . n 
A 1 22  THR 22  24  24  THR THR A . n 
A 1 23  THR 23  25  25  THR THR A . n 
A 1 24  THR 24  26  26  THR THR A . n 
A 1 25  LEU 25  27  27  LEU LEU A . n 
A 1 26  ASN 26  28  28  ASN ASN A . n 
A 1 27  GLY 27  29  29  GLY GLY A . n 
A 1 28  LEU 28  30  30  LEU LEU A . n 
A 1 29  TRP 29  31  31  TRP TRP A . n 
A 1 30  LEU 30  32  32  LEU LEU A . n 
A 1 31  ASP 31  33  33  ASP ASP A . n 
A 1 32  ASP 32  34  34  ASP ASP A . n 
A 1 33  VAL 33  35  35  VAL VAL A . n 
A 1 34  VAL 34  36  36  VAL VAL A . n 
A 1 35  TYR 35  37  37  TYR TYR A . n 
A 1 36  CYS 36  38  38  CYS CYS A . n 
A 1 37  PRO 37  39  39  PRO PRO A . n 
A 1 38  ARG 38  40  40  ARG ARG A . n 
A 1 39  HIS 39  41  41  HIS HIS A . n 
A 1 40  VAL 40  42  42  VAL VAL A . n 
A 1 41  ILE 41  43  43  ILE ILE A . n 
A 1 42  CYS 42  44  44  CYS CYS A . n 
A 1 43  THR 43  45  45  THR THR A . n 
A 1 44  SER 44  46  46  SER SER A . n 
A 1 45  GLU 45  47  47  GLU GLU A . n 
A 1 46  ASP 46  48  48  ASP ASP A . n 
A 1 47  MET 47  49  49  MET MET A . n 
A 1 48  LEU 48  50  50  LEU LEU A . n 
A 1 49  ASN 49  51  51  ASN ASN A . n 
A 1 50  PRO 50  52  52  PRO PRO A . n 
A 1 51  ASN 51  53  53  ASN ASN A . n 
A 1 52  TYR 52  54  54  TYR TYR A . n 
A 1 53  GLU 53  55  55  GLU GLU A . n 
A 1 54  ASP 54  56  56  ASP ASP A . n 
A 1 55  LEU 55  57  57  LEU LEU A . n 
A 1 56  LEU 56  58  58  LEU LEU A . n 
A 1 57  ILE 57  59  59  ILE ILE A . n 
A 1 58  ARG 58  60  60  ARG ARG A . n 
A 1 59  LYS 59  61  61  LYS LYS A . n 
A 1 60  SER 60  62  62  SER SER A . n 
A 1 61  ASN 61  63  63  ASN ASN A . n 
A 1 62  HIS 62  64  64  HIS HIS A . n 
A 1 63  ASN 63  65  65  ASN ASN A . n 
A 1 64  PHE 64  66  66  PHE PHE A . n 
A 1 65  LEU 65  67  67  LEU LEU A . n 
A 1 66  VAL 66  68  68  VAL VAL A . n 
A 1 67  GLN 67  69  69  GLN GLN A . n 
A 1 68  ALA 68  70  70  ALA ALA A . n 
A 1 69  GLY 69  71  71  GLY GLY A . n 
A 1 70  ASN 70  72  72  ASN ASN A . n 
A 1 71  VAL 71  73  73  VAL VAL A . n 
A 1 72  GLN 72  74  74  GLN GLN A . n 
A 1 73  LEU 73  75  75  LEU LEU A . n 
A 1 74  ARG 74  76  76  ARG ARG A . n 
A 1 75  VAL 75  77  77  VAL VAL A . n 
A 1 76  ILE 76  78  78  ILE ILE A . n 
A 1 77  GLY 77  79  79  GLY GLY A . n 
A 1 78  HIS 78  80  80  HIS HIS A . n 
A 1 79  SER 79  81  81  SER SER A . n 
A 1 80  MET 80  82  82  MET MET A . n 
A 1 81  GLN 81  83  83  GLN GLN A . n 
A 1 82  ASN 82  84  84  ASN ASN A . n 
A 1 83  CYS 83  85  85  CYS CYS A . n 
A 1 84  VAL 84  86  86  VAL VAL A . n 
A 1 85  LEU 85  87  87  LEU LEU A . n 
A 1 86  LYS 86  88  88  LYS LYS A . n 
A 1 87  LEU 87  89  89  LEU LEU A . n 
A 1 88  LYS 88  90  90  LYS LYS A . n 
A 1 89  VAL 89  91  91  VAL VAL A . n 
A 1 90  ASP 90  92  92  ASP ASP A . n 
A 1 91  THR 91  93  93  THR THR A . n 
A 1 92  ALA 92  94  94  ALA ALA A . n 
A 1 93  ASN 93  95  95  ASN ASN A . n 
A 1 94  PRO 94  96  96  PRO PRO A . n 
A 1 95  LYS 95  97  97  LYS LYS A . n 
A 1 96  THR 96  98  98  THR THR A . n 
A 1 97  PRO 97  99  99  PRO PRO A . n 
A 1 98  LYS 98  100 100 LYS LYS A . n 
A 1 99  TYR 99  101 101 TYR TYR A . n 
A 1 100 LYS 100 102 102 LYS LYS A . n 
A 1 101 PHE 101 103 103 PHE PHE A . n 
A 1 102 VAL 102 104 104 VAL VAL A . n 
A 1 103 ARG 103 105 105 ARG ARG A . n 
A 1 104 ILE 104 106 106 ILE ILE A . n 
A 1 105 GLN 105 107 107 GLN GLN A . n 
A 1 106 PRO 106 108 108 PRO PRO A . n 
A 1 107 GLY 107 109 109 GLY GLY A . n 
A 1 108 GLN 108 110 110 GLN GLN A . n 
A 1 109 THR 109 111 111 THR THR A . n 
A 1 110 PHE 110 112 112 PHE PHE A . n 
A 1 111 SER 111 113 113 SER SER A . n 
A 1 112 VAL 112 114 114 VAL VAL A . n 
A 1 113 LEU 113 115 115 LEU LEU A . n 
A 1 114 ALA 114 116 116 ALA ALA A . n 
A 1 115 CYS 115 117 117 CYS CYS A . n 
A 1 116 TYR 116 118 118 TYR TYR A . n 
A 1 117 ASN 117 119 119 ASN ASN A . n 
A 1 118 GLY 118 120 120 GLY GLY A . n 
A 1 119 SER 119 121 121 SER SER A . n 
A 1 120 PRO 120 122 122 PRO PRO A . n 
A 1 121 SER 121 123 123 SER SER A . n 
A 1 122 GLY 122 124 124 GLY GLY A . n 
A 1 123 VAL 123 125 125 VAL VAL A . n 
A 1 124 TYR 124 126 126 TYR TYR A . n 
A 1 125 GLN 125 127 127 GLN GLN A . n 
A 1 126 CYS 126 128 128 CYS CYS A . n 
A 1 127 ALA 127 129 129 ALA ALA A . n 
A 1 128 MET 128 130 130 MET MET A . n 
A 1 129 ARG 129 131 131 ARG ARG A . n 
A 1 130 PRO 130 132 132 PRO PRO A . n 
A 1 131 ASN 131 133 133 ASN ASN A . n 
A 1 132 PHE 132 134 134 PHE PHE A . n 
A 1 133 THR 133 135 135 THR THR A . n 
A 1 134 ILE 134 136 136 ILE ILE A . n 
A 1 135 LYS 135 137 137 LYS LYS A . n 
A 1 136 GLY 136 138 138 GLY GLY A . n 
A 1 137 SER 137 139 139 SER SER A . n 
A 1 138 PHE 138 140 140 PHE PHE A . n 
A 1 139 LEU 139 141 141 LEU LEU A . n 
A 1 140 ALA 140 142 142 ALA ALA A . n 
A 1 141 GLY 141 143 143 GLY GLY A . n 
A 1 142 SER 142 144 144 SER SER A . n 
A 1 143 CYS 143 145 145 CYS CYS A . n 
A 1 144 GLY 144 146 146 GLY GLY A . n 
A 1 145 SER 145 147 147 SER SER A . n 
A 1 146 VAL 146 148 148 VAL VAL A . n 
A 1 147 GLY 147 149 149 GLY GLY A . n 
A 1 148 PHE 148 150 150 PHE PHE A . n 
A 1 149 ASN 149 151 151 ASN ASN A . n 
A 1 150 ILE 150 152 152 ILE ILE A . n 
A 1 151 ASP 151 153 153 ASP ASP A . n 
A 1 152 TYR 152 154 154 TYR TYR A . n 
A 1 153 ASP 153 155 155 ASP ASP A . n 
A 1 154 CYS 154 156 156 CYS CYS A . n 
A 1 155 VAL 155 157 157 VAL VAL A . n 
A 1 156 SER 156 158 158 SER SER A . n 
A 1 157 PHE 157 159 159 PHE PHE A . n 
A 1 158 CYS 158 160 160 CYS CYS A . n 
A 1 159 TYR 159 161 161 TYR TYR A . n 
A 1 160 MET 160 162 162 MET MET A . n 
A 1 161 ALA 161 163 163 ALA ALA A . n 
A 1 162 HIS 162 164 164 HIS HIS A . n 
A 1 163 MET 163 165 165 MET MET A . n 
A 1 164 GLU 164 166 166 GLU GLU A . n 
A 1 165 LEU 165 167 167 LEU LEU A . n 
A 1 166 PRO 166 168 168 PRO PRO A . n 
A 1 167 THR 167 169 169 THR THR A . n 
A 1 168 GLY 168 170 170 GLY GLY A . n 
A 1 169 VAL 169 171 171 VAL VAL A . n 
A 1 170 HIS 170 172 172 HIS HIS A . n 
A 1 171 ALA 171 173 173 ALA ALA A . n 
A 1 172 GLY 172 174 174 GLY GLY A . n 
A 1 173 THR 173 175 175 THR THR A . n 
A 1 174 ASP 174 176 176 ASP ASP A . n 
A 1 175 LEU 175 177 177 LEU LEU A . n 
A 1 176 GLU 176 178 178 GLU GLU A . n 
A 1 177 GLY 177 179 179 GLY GLY A . n 
A 1 178 ASN 178 180 180 ASN ASN A . n 
A 1 179 PHE 179 181 181 PHE PHE A . n 
A 1 180 TYR 180 182 182 TYR TYR A . n 
A 1 181 GLY 181 183 183 GLY GLY A . n 
A 1 182 PRO 182 184 184 PRO PRO A . n 
A 1 183 PHE 183 185 185 PHE PHE A . n 
A 1 184 VAL 184 186 186 VAL VAL A . n 
A 1 185 ASP 185 187 187 ASP ASP A . n 
A 1 186 ARG 186 188 188 ARG ARG A . n 
A 1 187 GLN 187 189 189 GLN GLN A . n 
A 1 188 THR 188 190 190 THR THR A . n 
A 1 189 ALA 189 191 191 ALA ALA A . n 
A 1 190 GLN 190 192 192 GLN GLN A . n 
A 1 191 ALA 191 193 193 ALA ALA A . n 
A 1 192 ALA 192 194 194 ALA ALA A . n 
A 1 193 GLY 193 195 195 GLY GLY A . n 
A 1 194 THR 194 196 196 THR THR A . n 
A 1 195 ASP 195 197 197 ASP ASP A . n 
A 1 196 THR 196 198 198 THR THR A . n 
A 1 197 THR 197 199 199 THR THR A . n 
A 1 198 ILE 198 200 200 ILE ILE A . n 
A 1 199 THR 199 201 201 THR THR A . n 
A 1 200 VAL 200 202 202 VAL VAL A . n 
A 1 201 ASN 201 203 203 ASN ASN A . n 
A 1 202 VAL 202 204 204 VAL VAL A . n 
A 1 203 LEU 203 205 205 LEU LEU A . n 
A 1 204 ALA 204 206 206 ALA ALA A . n 
A 1 205 TRP 205 207 207 TRP TRP A . n 
A 1 206 LEU 206 208 208 LEU LEU A . n 
A 1 207 TYR 207 209 209 TYR TYR A . n 
A 1 208 ALA 208 210 210 ALA ALA A . n 
A 1 209 ALA 209 211 211 ALA ALA A . n 
A 1 210 VAL 210 212 212 VAL VAL A . n 
A 1 211 ILE 211 213 213 ILE ILE A . n 
A 1 212 ASN 212 214 214 ASN ASN A . n 
A 1 213 GLY 213 215 215 GLY GLY A . n 
A 1 214 ASP 214 216 216 ASP ASP A . n 
A 1 215 ARG 215 217 217 ARG ARG A . n 
A 1 216 TRP 216 218 218 TRP TRP A . n 
A 1 217 PHE 217 219 219 PHE PHE A . n 
A 1 218 LEU 218 220 220 LEU LEU A . n 
A 1 219 ASN 219 221 221 ASN ASN A . n 
A 1 220 ARG 220 222 222 ARG ARG A . n 
A 1 221 PHE 221 223 223 PHE PHE A . n 
A 1 222 THR 222 224 224 THR THR A . n 
A 1 223 THR 223 225 225 THR THR A . n 
A 1 224 THR 224 226 226 THR THR A . n 
A 1 225 LEU 225 227 227 LEU LEU A . n 
A 1 226 ASN 226 228 228 ASN ASN A . n 
A 1 227 ASP 227 229 229 ASP ASP A . n 
A 1 228 PHE 228 230 230 PHE PHE A . n 
A 1 229 ASN 229 231 231 ASN ASN A . n 
A 1 230 LEU 230 232 232 LEU LEU A . n 
A 1 231 VAL 231 233 233 VAL VAL A . n 
A 1 232 ALA 232 234 234 ALA ALA A . n 
A 1 233 MET 233 235 235 MET MET A . n 
A 1 234 LYS 234 236 236 LYS LYS A . n 
A 1 235 TYR 235 237 237 TYR TYR A . n 
A 1 236 ASN 236 238 238 ASN ASN A . n 
A 1 237 TYR 237 239 239 TYR TYR A . n 
A 1 238 GLU 238 240 240 GLU GLU A . n 
A 1 239 PRO 239 241 241 PRO PRO A . n 
A 1 240 LEU 240 242 242 LEU LEU A . n 
A 1 241 THR 241 243 243 THR THR A . n 
A 1 242 GLN 242 244 244 GLN GLN A . n 
A 1 243 ASP 243 245 245 ASP ASP A . n 
A 1 244 HIS 244 246 246 HIS HIS A . n 
A 1 245 VAL 245 247 247 VAL VAL A . n 
A 1 246 ASP 246 248 248 ASP ASP A . n 
A 1 247 ILE 247 249 249 ILE ILE A . n 
A 1 248 LEU 248 250 250 LEU LEU A . n 
A 1 249 GLY 249 251 251 GLY GLY A . n 
A 1 250 PRO 250 252 252 PRO PRO A . n 
A 1 251 LEU 251 253 253 LEU LEU A . n 
A 1 252 SER 252 254 254 SER SER A . n 
A 1 253 ALA 253 255 255 ALA ALA A . n 
A 1 254 GLN 254 256 256 GLN GLN A . n 
A 1 255 THR 255 257 257 THR THR A . n 
A 1 256 GLY 256 258 258 GLY GLY A . n 
A 1 257 ILE 257 259 259 ILE ILE A . n 
A 1 258 ALA 258 260 260 ALA ALA A . n 
A 1 259 VAL 259 261 261 VAL VAL A . n 
A 1 260 LEU 260 262 262 LEU LEU A . n 
A 1 261 ASP 261 263 263 ASP ASP A . n 
A 1 262 MET 262 264 264 MET MET A . n 
A 1 263 CYS 263 265 265 CYS CYS A . n 
A 1 264 ALA 264 266 266 ALA ALA A . n 
A 1 265 SER 265 267 267 SER SER A . n 
A 1 266 LEU 266 268 268 LEU LEU A . n 
A 1 267 LYS 267 269 269 LYS LYS A . n 
A 1 268 GLU 268 270 270 GLU GLU A . n 
A 1 269 LEU 269 271 271 LEU LEU A . n 
A 1 270 LEU 270 272 272 LEU LEU A . n 
A 1 271 GLN 271 273 273 GLN GLN A . n 
A 1 272 ASN 272 274 274 ASN ASN A . n 
A 1 273 GLY 273 275 275 GLY GLY A . n 
A 1 274 MET 274 276 276 MET MET A . n 
A 1 275 ASN 275 277 277 ASN ASN A . n 
A 1 276 GLY 276 278 278 GLY GLY A . n 
A 1 277 ARG 277 279 279 ARG ARG A . n 
A 1 278 THR 278 280 280 THR THR A . n 
A 1 279 ILE 279 281 281 ILE ILE A . n 
A 1 280 LEU 280 282 282 LEU LEU A . n 
A 1 281 GLY 281 283 283 GLY GLY A . n 
A 1 282 SER 282 284 284 SER SER A . n 
A 1 283 ALA 283 285 285 ALA ALA A . n 
A 1 284 LEU 284 286 286 LEU LEU A . n 
A 1 285 LEU 285 287 287 LEU LEU A . n 
A 1 286 GLU 286 288 288 GLU GLU A . n 
A 1 287 ASP 287 289 289 ASP ASP A . n 
A 1 288 GLU 288 290 290 GLU GLU A . n 
A 1 289 PHE 289 291 291 PHE PHE A . n 
A 1 290 THR 290 292 292 THR THR A . n 
A 1 291 PRO 291 293 293 PRO PRO A . n 
A 1 292 PHE 292 294 294 PHE PHE A . n 
A 1 293 ASP 293 295 295 ASP ASP A . n 
A 1 294 VAL 294 296 296 VAL VAL A . n 
A 1 295 VAL 295 297 297 VAL VAL A . n 
A 1 296 ARG 296 298 298 ARG ARG A . n 
B 1 1   PHE 1   3   3   PHE PHE B . n 
B 1 2   ARG 2   4   4   ARG ARG B . n 
B 1 3   LYS 3   5   5   LYS LYS B . n 
B 1 4   MET 4   6   6   MET MET B . n 
B 1 5   ALA 5   7   7   ALA ALA B . n 
B 1 6   PHE 6   8   8   PHE PHE B . n 
B 1 7   PRO 7   9   9   PRO PRO B . n 
B 1 8   SER 8   10  10  SER SER B . n 
B 1 9   GLY 9   11  11  GLY GLY B . n 
B 1 10  LYS 10  12  12  LYS LYS B . n 
B 1 11  VAL 11  13  13  VAL VAL B . n 
B 1 12  GLU 12  14  14  GLU GLU B . n 
B 1 13  GLY 13  15  15  GLY GLY B . n 
B 1 14  CYS 14  16  16  CYS CYS B . n 
B 1 15  MET 15  17  17  MET MET B . n 
B 1 16  VAL 16  18  18  VAL VAL B . n 
B 1 17  GLN 17  19  19  GLN GLN B . n 
B 1 18  VAL 18  20  20  VAL VAL B . n 
B 1 19  THR 19  21  21  THR THR B . n 
B 1 20  CYS 20  22  22  CYS CYS B . n 
B 1 21  GLY 21  23  23  GLY GLY B . n 
B 1 22  THR 22  24  24  THR THR B . n 
B 1 23  THR 23  25  25  THR THR B . n 
B 1 24  THR 24  26  26  THR THR B . n 
B 1 25  LEU 25  27  27  LEU LEU B . n 
B 1 26  ASN 26  28  28  ASN ASN B . n 
B 1 27  GLY 27  29  29  GLY GLY B . n 
B 1 28  LEU 28  30  30  LEU LEU B . n 
B 1 29  TRP 29  31  31  TRP TRP B . n 
B 1 30  LEU 30  32  32  LEU LEU B . n 
B 1 31  ASP 31  33  33  ASP ASP B . n 
B 1 32  ASP 32  34  34  ASP ASP B . n 
B 1 33  VAL 33  35  35  VAL VAL B . n 
B 1 34  VAL 34  36  36  VAL VAL B . n 
B 1 35  TYR 35  37  37  TYR TYR B . n 
B 1 36  CYS 36  38  38  CYS CYS B . n 
B 1 37  PRO 37  39  39  PRO PRO B . n 
B 1 38  ARG 38  40  40  ARG ARG B . n 
B 1 39  HIS 39  41  41  HIS HIS B . n 
B 1 40  VAL 40  42  42  VAL VAL B . n 
B 1 41  ILE 41  43  43  ILE ILE B . n 
B 1 42  CYS 42  44  44  CYS CYS B . n 
B 1 43  THR 43  45  45  THR THR B . n 
B 1 44  SER 44  46  46  SER SER B . n 
B 1 45  GLU 45  47  47  GLU GLU B . n 
B 1 46  ASP 46  48  48  ASP ASP B . n 
B 1 47  MET 47  49  49  MET MET B . n 
B 1 48  LEU 48  50  50  LEU LEU B . n 
B 1 49  ASN 49  51  51  ASN ASN B . n 
B 1 50  PRO 50  52  52  PRO PRO B . n 
B 1 51  ASN 51  53  53  ASN ASN B . n 
B 1 52  TYR 52  54  54  TYR TYR B . n 
B 1 53  GLU 53  55  55  GLU GLU B . n 
B 1 54  ASP 54  56  56  ASP ASP B . n 
B 1 55  LEU 55  57  57  LEU LEU B . n 
B 1 56  LEU 56  58  58  LEU LEU B . n 
B 1 57  ILE 57  59  59  ILE ILE B . n 
B 1 58  ARG 58  60  60  ARG ARG B . n 
B 1 59  LYS 59  61  61  LYS LYS B . n 
B 1 60  SER 60  62  62  SER SER B . n 
B 1 61  ASN 61  63  63  ASN ASN B . n 
B 1 62  HIS 62  64  64  HIS HIS B . n 
B 1 63  ASN 63  65  65  ASN ASN B . n 
B 1 64  PHE 64  66  66  PHE PHE B . n 
B 1 65  LEU 65  67  67  LEU LEU B . n 
B 1 66  VAL 66  68  68  VAL VAL B . n 
B 1 67  GLN 67  69  69  GLN GLN B . n 
B 1 68  ALA 68  70  70  ALA ALA B . n 
B 1 69  GLY 69  71  71  GLY GLY B . n 
B 1 70  ASN 70  72  72  ASN ASN B . n 
B 1 71  VAL 71  73  73  VAL VAL B . n 
B 1 72  GLN 72  74  74  GLN GLN B . n 
B 1 73  LEU 73  75  75  LEU LEU B . n 
B 1 74  ARG 74  76  76  ARG ARG B . n 
B 1 75  VAL 75  77  77  VAL VAL B . n 
B 1 76  ILE 76  78  78  ILE ILE B . n 
B 1 77  GLY 77  79  79  GLY GLY B . n 
B 1 78  HIS 78  80  80  HIS HIS B . n 
B 1 79  SER 79  81  81  SER SER B . n 
B 1 80  MET 80  82  82  MET MET B . n 
B 1 81  GLN 81  83  83  GLN GLN B . n 
B 1 82  ASN 82  84  84  ASN ASN B . n 
B 1 83  CYS 83  85  85  CYS CYS B . n 
B 1 84  VAL 84  86  86  VAL VAL B . n 
B 1 85  LEU 85  87  87  LEU LEU B . n 
B 1 86  LYS 86  88  88  LYS LYS B . n 
B 1 87  LEU 87  89  89  LEU LEU B . n 
B 1 88  LYS 88  90  90  LYS LYS B . n 
B 1 89  VAL 89  91  91  VAL VAL B . n 
B 1 90  ASP 90  92  92  ASP ASP B . n 
B 1 91  THR 91  93  93  THR THR B . n 
B 1 92  ALA 92  94  94  ALA ALA B . n 
B 1 93  ASN 93  95  95  ASN ASN B . n 
B 1 94  PRO 94  96  96  PRO PRO B . n 
B 1 95  LYS 95  97  97  LYS LYS B . n 
B 1 96  THR 96  98  98  THR THR B . n 
B 1 97  PRO 97  99  99  PRO PRO B . n 
B 1 98  LYS 98  100 100 LYS LYS B . n 
B 1 99  TYR 99  101 101 TYR TYR B . n 
B 1 100 LYS 100 102 102 LYS LYS B . n 
B 1 101 PHE 101 103 103 PHE PHE B . n 
B 1 102 VAL 102 104 104 VAL VAL B . n 
B 1 103 ARG 103 105 105 ARG ARG B . n 
B 1 104 ILE 104 106 106 ILE ILE B . n 
B 1 105 GLN 105 107 107 GLN GLN B . n 
B 1 106 PRO 106 108 108 PRO PRO B . n 
B 1 107 GLY 107 109 109 GLY GLY B . n 
B 1 108 GLN 108 110 110 GLN GLN B . n 
B 1 109 THR 109 111 111 THR THR B . n 
B 1 110 PHE 110 112 112 PHE PHE B . n 
B 1 111 SER 111 113 113 SER SER B . n 
B 1 112 VAL 112 114 114 VAL VAL B . n 
B 1 113 LEU 113 115 115 LEU LEU B . n 
B 1 114 ALA 114 116 116 ALA ALA B . n 
B 1 115 CYS 115 117 117 CYS CYS B . n 
B 1 116 TYR 116 118 118 TYR TYR B . n 
B 1 117 ASN 117 119 119 ASN ASN B . n 
B 1 118 GLY 118 120 120 GLY GLY B . n 
B 1 119 SER 119 121 121 SER SER B . n 
B 1 120 PRO 120 122 122 PRO PRO B . n 
B 1 121 SER 121 123 123 SER SER B . n 
B 1 122 GLY 122 124 124 GLY GLY B . n 
B 1 123 VAL 123 125 125 VAL VAL B . n 
B 1 124 TYR 124 126 126 TYR TYR B . n 
B 1 125 GLN 125 127 127 GLN GLN B . n 
B 1 126 CYS 126 128 128 CYS CYS B . n 
B 1 127 ALA 127 129 129 ALA ALA B . n 
B 1 128 MET 128 130 130 MET MET B . n 
B 1 129 ARG 129 131 131 ARG ARG B . n 
B 1 130 PRO 130 132 132 PRO PRO B . n 
B 1 131 ASN 131 133 133 ASN ASN B . n 
B 1 132 PHE 132 134 134 PHE PHE B . n 
B 1 133 THR 133 135 135 THR THR B . n 
B 1 134 ILE 134 136 136 ILE ILE B . n 
B 1 135 LYS 135 137 137 LYS LYS B . n 
B 1 136 GLY 136 138 138 GLY GLY B . n 
B 1 137 SER 137 139 139 SER SER B . n 
B 1 138 PHE 138 140 140 PHE PHE B . n 
B 1 139 LEU 139 141 141 LEU LEU B . n 
B 1 140 ALA 140 142 142 ALA ALA B . n 
B 1 141 GLY 141 143 143 GLY GLY B . n 
B 1 142 SER 142 144 144 SER SER B . n 
B 1 143 CYS 143 145 145 CYS CYS B . n 
B 1 144 GLY 144 146 146 GLY GLY B . n 
B 1 145 SER 145 147 147 SER SER B . n 
B 1 146 VAL 146 148 148 VAL VAL B . n 
B 1 147 GLY 147 149 149 GLY GLY B . n 
B 1 148 PHE 148 150 150 PHE PHE B . n 
B 1 149 ASN 149 151 151 ASN ASN B . n 
B 1 150 ILE 150 152 152 ILE ILE B . n 
B 1 151 ASP 151 153 153 ASP ASP B . n 
B 1 152 TYR 152 154 154 TYR TYR B . n 
B 1 153 ASP 153 155 155 ASP ASP B . n 
B 1 154 CYS 154 156 156 CYS CYS B . n 
B 1 155 VAL 155 157 157 VAL VAL B . n 
B 1 156 SER 156 158 158 SER SER B . n 
B 1 157 PHE 157 159 159 PHE PHE B . n 
B 1 158 CYS 158 160 160 CYS CYS B . n 
B 1 159 TYR 159 161 161 TYR TYR B . n 
B 1 160 MET 160 162 162 MET MET B . n 
B 1 161 ALA 161 163 163 ALA ALA B . n 
B 1 162 HIS 162 164 164 HIS HIS B . n 
B 1 163 MET 163 165 165 MET MET B . n 
B 1 164 GLU 164 166 166 GLU GLU B . n 
B 1 165 LEU 165 167 167 LEU LEU B . n 
B 1 166 PRO 166 168 168 PRO PRO B . n 
B 1 167 THR 167 169 169 THR THR B . n 
B 1 168 GLY 168 170 170 GLY GLY B . n 
B 1 169 VAL 169 171 171 VAL VAL B . n 
B 1 170 HIS 170 172 172 HIS HIS B . n 
B 1 171 ALA 171 173 173 ALA ALA B . n 
B 1 172 GLY 172 174 174 GLY GLY B . n 
B 1 173 THR 173 175 175 THR THR B . n 
B 1 174 ASP 174 176 176 ASP ASP B . n 
B 1 175 LEU 175 177 177 LEU LEU B . n 
B 1 176 GLU 176 178 178 GLU GLU B . n 
B 1 177 GLY 177 179 179 GLY GLY B . n 
B 1 178 ASN 178 180 180 ASN ASN B . n 
B 1 179 PHE 179 181 181 PHE PHE B . n 
B 1 180 TYR 180 182 182 TYR TYR B . n 
B 1 181 GLY 181 183 183 GLY GLY B . n 
B 1 182 PRO 182 184 184 PRO PRO B . n 
B 1 183 PHE 183 185 185 PHE PHE B . n 
B 1 184 VAL 184 186 186 VAL VAL B . n 
B 1 185 ASP 185 187 187 ASP ASP B . n 
B 1 186 ARG 186 188 188 ARG ARG B . n 
B 1 187 GLN 187 189 189 GLN GLN B . n 
B 1 188 THR 188 190 190 THR THR B . n 
B 1 189 ALA 189 191 191 ALA ALA B . n 
B 1 190 GLN 190 192 192 GLN GLN B . n 
B 1 191 ALA 191 193 193 ALA ALA B . n 
B 1 192 ALA 192 194 194 ALA ALA B . n 
B 1 193 GLY 193 195 195 GLY GLY B . n 
B 1 194 THR 194 196 196 THR THR B . n 
B 1 195 ASP 195 197 197 ASP ASP B . n 
B 1 196 THR 196 198 198 THR THR B . n 
B 1 197 THR 197 199 199 THR THR B . n 
B 1 198 ILE 198 200 200 ILE ILE B . n 
B 1 199 THR 199 201 201 THR THR B . n 
B 1 200 VAL 200 202 202 VAL VAL B . n 
B 1 201 ASN 201 203 203 ASN ASN B . n 
B 1 202 VAL 202 204 204 VAL VAL B . n 
B 1 203 LEU 203 205 205 LEU LEU B . n 
B 1 204 ALA 204 206 206 ALA ALA B . n 
B 1 205 TRP 205 207 207 TRP TRP B . n 
B 1 206 LEU 206 208 208 LEU LEU B . n 
B 1 207 TYR 207 209 209 TYR TYR B . n 
B 1 208 ALA 208 210 210 ALA ALA B . n 
B 1 209 ALA 209 211 211 ALA ALA B . n 
B 1 210 VAL 210 212 212 VAL VAL B . n 
B 1 211 ILE 211 213 213 ILE ILE B . n 
B 1 212 ASN 212 214 214 ASN ASN B . n 
B 1 213 GLY 213 215 215 GLY GLY B . n 
B 1 214 ASP 214 216 216 ASP ASP B . n 
B 1 215 ARG 215 217 217 ARG ARG B . n 
B 1 216 TRP 216 218 218 TRP TRP B . n 
B 1 217 PHE 217 219 219 PHE PHE B . n 
B 1 218 LEU 218 220 220 LEU LEU B . n 
B 1 219 ASN 219 221 221 ASN ASN B . n 
B 1 220 ARG 220 222 222 ARG ARG B . n 
B 1 221 PHE 221 223 223 PHE PHE B . n 
B 1 222 THR 222 224 224 THR THR B . n 
B 1 223 THR 223 225 225 THR THR B . n 
B 1 224 THR 224 226 226 THR THR B . n 
B 1 225 LEU 225 227 227 LEU LEU B . n 
B 1 226 ASN 226 228 228 ASN ASN B . n 
B 1 227 ASP 227 229 229 ASP ASP B . n 
B 1 228 PHE 228 230 230 PHE PHE B . n 
B 1 229 ASN 229 231 231 ASN ASN B . n 
B 1 230 LEU 230 232 232 LEU LEU B . n 
B 1 231 VAL 231 233 233 VAL VAL B . n 
B 1 232 ALA 232 234 234 ALA ALA B . n 
B 1 233 MET 233 235 235 MET MET B . n 
B 1 234 LYS 234 236 236 LYS LYS B . n 
B 1 235 TYR 235 237 237 TYR TYR B . n 
B 1 236 ASN 236 238 238 ASN ASN B . n 
B 1 237 TYR 237 239 239 TYR TYR B . n 
B 1 238 GLU 238 240 240 GLU GLU B . n 
B 1 239 PRO 239 241 241 PRO PRO B . n 
B 1 240 LEU 240 242 242 LEU LEU B . n 
B 1 241 THR 241 243 243 THR THR B . n 
B 1 242 GLN 242 244 244 GLN GLN B . n 
B 1 243 ASP 243 245 245 ASP ASP B . n 
B 1 244 HIS 244 246 246 HIS HIS B . n 
B 1 245 VAL 245 247 247 VAL VAL B . n 
B 1 246 ASP 246 248 248 ASP ASP B . n 
B 1 247 ILE 247 249 249 ILE ILE B . n 
B 1 248 LEU 248 250 250 LEU LEU B . n 
B 1 249 GLY 249 251 251 GLY GLY B . n 
B 1 250 PRO 250 252 252 PRO PRO B . n 
B 1 251 LEU 251 253 253 LEU LEU B . n 
B 1 252 SER 252 254 254 SER SER B . n 
B 1 253 ALA 253 255 255 ALA ALA B . n 
B 1 254 GLN 254 256 256 GLN GLN B . n 
B 1 255 THR 255 257 257 THR THR B . n 
B 1 256 GLY 256 258 258 GLY GLY B . n 
B 1 257 ILE 257 259 259 ILE ILE B . n 
B 1 258 ALA 258 260 260 ALA ALA B . n 
B 1 259 VAL 259 261 261 VAL VAL B . n 
B 1 260 LEU 260 262 262 LEU LEU B . n 
B 1 261 ASP 261 263 263 ASP ASP B . n 
B 1 262 MET 262 264 264 MET MET B . n 
B 1 263 CYS 263 265 265 CYS CYS B . n 
B 1 264 ALA 264 266 266 ALA ALA B . n 
B 1 265 SER 265 267 267 SER SER B . n 
B 1 266 LEU 266 268 268 LEU LEU B . n 
B 1 267 LYS 267 269 269 LYS LYS B . n 
B 1 268 GLU 268 270 270 GLU GLU B . n 
B 1 269 LEU 269 271 271 LEU LEU B . n 
B 1 270 LEU 270 272 272 LEU LEU B . n 
B 1 271 GLN 271 273 273 GLN GLN B . n 
B 1 272 ASN 272 274 274 ASN ASN B . n 
B 1 273 GLY 273 275 275 GLY GLY B . n 
B 1 274 MET 274 276 276 MET MET B . n 
B 1 275 ASN 275 277 277 ASN ASN B . n 
B 1 276 GLY 276 278 278 GLY GLY B . n 
B 1 277 ARG 277 279 279 ARG ARG B . n 
B 1 278 THR 278 280 280 THR THR B . n 
B 1 279 ILE 279 281 281 ILE ILE B . n 
B 1 280 LEU 280 282 282 LEU LEU B . n 
B 1 281 GLY 281 283 283 GLY GLY B . n 
B 1 282 SER 282 284 284 SER SER B . n 
B 1 283 ALA 283 285 285 ALA ALA B . n 
B 1 284 LEU 284 286 286 LEU LEU B . n 
B 1 285 LEU 285 287 287 LEU LEU B . n 
B 1 286 GLU 286 288 288 GLU GLU B . n 
B 1 287 ASP 287 289 289 ASP ASP B . n 
B 1 288 GLU 288 290 290 GLU GLU B . n 
B 1 289 PHE 289 291 291 PHE PHE B . n 
B 1 290 THR 290 292 292 THR THR B . n 
B 1 291 PRO 291 293 293 PRO PRO B . n 
B 1 292 PHE 292 294 294 PHE PHE B . n 
B 1 293 ASP 293 295 295 ASP ASP B . n 
B 1 294 VAL 294 296 296 VAL VAL B . n 
B 1 295 VAL 295 297 297 VAL VAL B . n 
B 1 296 ARG 296 298 298 ARG ARG B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        FHR 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   FHR 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 FHR 1   301 301 FHR LIG B . 
D 3 HOH 1   301 308 HOH HOH A . 
D 3 HOH 2   302 243 HOH HOH A . 
D 3 HOH 3   303 186 HOH HOH A . 
D 3 HOH 4   304 221 HOH HOH A . 
D 3 HOH 5   305 189 HOH HOH A . 
D 3 HOH 6   306 237 HOH HOH A . 
D 3 HOH 7   307 197 HOH HOH A . 
D 3 HOH 8   308 115 HOH HOH A . 
D 3 HOH 9   309 107 HOH HOH A . 
D 3 HOH 10  310 193 HOH HOH A . 
D 3 HOH 11  311 73  HOH HOH A . 
D 3 HOH 12  312 49  HOH HOH A . 
D 3 HOH 13  313 79  HOH HOH A . 
D 3 HOH 14  314 51  HOH HOH A . 
D 3 HOH 15  315 6   HOH HOH A . 
D 3 HOH 16  316 90  HOH HOH A . 
D 3 HOH 17  317 108 HOH HOH A . 
D 3 HOH 18  318 36  HOH HOH A . 
D 3 HOH 19  319 161 HOH HOH A . 
D 3 HOH 20  320 218 HOH HOH A . 
D 3 HOH 21  321 53  HOH HOH A . 
D 3 HOH 22  322 196 HOH HOH A . 
D 3 HOH 23  323 94  HOH HOH A . 
D 3 HOH 24  324 74  HOH HOH A . 
D 3 HOH 25  325 234 HOH HOH A . 
D 3 HOH 26  326 143 HOH HOH A . 
D 3 HOH 27  327 65  HOH HOH A . 
D 3 HOH 28  328 176 HOH HOH A . 
D 3 HOH 29  329 97  HOH HOH A . 
D 3 HOH 30  330 298 HOH HOH A . 
D 3 HOH 31  331 22  HOH HOH A . 
D 3 HOH 32  332 283 HOH HOH A . 
D 3 HOH 33  333 140 HOH HOH A . 
D 3 HOH 34  334 66  HOH HOH A . 
D 3 HOH 35  335 222 HOH HOH A . 
D 3 HOH 36  336 24  HOH HOH A . 
D 3 HOH 37  337 151 HOH HOH A . 
D 3 HOH 38  338 76  HOH HOH A . 
D 3 HOH 39  339 25  HOH HOH A . 
D 3 HOH 40  340 271 HOH HOH A . 
D 3 HOH 41  341 266 HOH HOH A . 
D 3 HOH 42  342 179 HOH HOH A . 
D 3 HOH 43  343 177 HOH HOH A . 
D 3 HOH 44  344 226 HOH HOH A . 
D 3 HOH 45  345 316 HOH HOH A . 
D 3 HOH 46  346 290 HOH HOH A . 
D 3 HOH 47  347 229 HOH HOH A . 
D 3 HOH 48  348 145 HOH HOH A . 
D 3 HOH 49  349 150 HOH HOH A . 
D 3 HOH 50  350 91  HOH HOH A . 
D 3 HOH 51  351 69  HOH HOH A . 
D 3 HOH 52  352 30  HOH HOH A . 
D 3 HOH 53  353 13  HOH HOH A . 
D 3 HOH 54  354 138 HOH HOH A . 
D 3 HOH 55  355 180 HOH HOH A . 
D 3 HOH 56  356 230 HOH HOH A . 
D 3 HOH 57  357 332 HOH HOH A . 
D 3 HOH 58  358 58  HOH HOH A . 
D 3 HOH 59  359 183 HOH HOH A . 
D 3 HOH 60  360 48  HOH HOH A . 
D 3 HOH 61  361 158 HOH HOH A . 
D 3 HOH 62  362 286 HOH HOH A . 
D 3 HOH 63  363 87  HOH HOH A . 
D 3 HOH 64  364 268 HOH HOH A . 
D 3 HOH 65  365 164 HOH HOH A . 
D 3 HOH 66  366 7   HOH HOH A . 
D 3 HOH 67  367 303 HOH HOH A . 
D 3 HOH 68  368 260 HOH HOH A . 
D 3 HOH 69  369 297 HOH HOH A . 
D 3 HOH 70  370 103 HOH HOH A . 
D 3 HOH 71  371 205 HOH HOH A . 
D 3 HOH 72  372 84  HOH HOH A . 
D 3 HOH 73  373 56  HOH HOH A . 
D 3 HOH 74  374 60  HOH HOH A . 
D 3 HOH 75  375 45  HOH HOH A . 
D 3 HOH 76  376 184 HOH HOH A . 
D 3 HOH 77  377 265 HOH HOH A . 
D 3 HOH 78  378 317 HOH HOH A . 
D 3 HOH 79  379 195 HOH HOH A . 
D 3 HOH 80  380 123 HOH HOH A . 
D 3 HOH 81  381 300 HOH HOH A . 
D 3 HOH 82  382 153 HOH HOH A . 
D 3 HOH 83  383 39  HOH HOH A . 
D 3 HOH 84  384 173 HOH HOH A . 
D 3 HOH 85  385 305 HOH HOH A . 
D 3 HOH 86  386 41  HOH HOH A . 
D 3 HOH 87  387 70  HOH HOH A . 
D 3 HOH 88  388 83  HOH HOH A . 
D 3 HOH 89  389 52  HOH HOH A . 
D 3 HOH 90  390 215 HOH HOH A . 
D 3 HOH 91  391 16  HOH HOH A . 
D 3 HOH 92  392 59  HOH HOH A . 
D 3 HOH 93  393 71  HOH HOH A . 
D 3 HOH 94  394 35  HOH HOH A . 
D 3 HOH 95  395 206 HOH HOH A . 
D 3 HOH 96  396 156 HOH HOH A . 
D 3 HOH 97  397 2   HOH HOH A . 
D 3 HOH 98  398 54  HOH HOH A . 
D 3 HOH 99  399 105 HOH HOH A . 
D 3 HOH 100 400 21  HOH HOH A . 
D 3 HOH 101 401 17  HOH HOH A . 
D 3 HOH 102 402 5   HOH HOH A . 
D 3 HOH 103 403 279 HOH HOH A . 
D 3 HOH 104 404 327 HOH HOH A . 
D 3 HOH 105 405 315 HOH HOH A . 
D 3 HOH 106 406 171 HOH HOH A . 
D 3 HOH 107 407 32  HOH HOH A . 
D 3 HOH 108 408 240 HOH HOH A . 
D 3 HOH 109 409 89  HOH HOH A . 
D 3 HOH 110 410 15  HOH HOH A . 
D 3 HOH 111 411 121 HOH HOH A . 
D 3 HOH 112 412 331 HOH HOH A . 
D 3 HOH 113 413 125 HOH HOH A . 
D 3 HOH 114 414 38  HOH HOH A . 
D 3 HOH 115 415 178 HOH HOH A . 
D 3 HOH 116 416 264 HOH HOH A . 
D 3 HOH 117 417 321 HOH HOH A . 
D 3 HOH 118 418 129 HOH HOH A . 
D 3 HOH 119 419 104 HOH HOH A . 
D 3 HOH 120 420 132 HOH HOH A . 
D 3 HOH 121 421 255 HOH HOH A . 
D 3 HOH 122 422 67  HOH HOH A . 
D 3 HOH 123 423 267 HOH HOH A . 
D 3 HOH 124 424 262 HOH HOH A . 
D 3 HOH 125 425 92  HOH HOH A . 
D 3 HOH 126 426 295 HOH HOH A . 
D 3 HOH 127 427 163 HOH HOH A . 
D 3 HOH 128 428 269 HOH HOH A . 
D 3 HOH 129 429 112 HOH HOH A . 
D 3 HOH 130 430 124 HOH HOH A . 
D 3 HOH 131 431 336 HOH HOH A . 
D 3 HOH 132 432 328 HOH HOH A . 
D 3 HOH 133 433 309 HOH HOH A . 
D 3 HOH 134 434 109 HOH HOH A . 
D 3 HOH 135 435 202 HOH HOH A . 
D 3 HOH 136 436 318 HOH HOH A . 
D 3 HOH 137 437 302 HOH HOH A . 
D 3 HOH 138 438 258 HOH HOH A . 
D 3 HOH 139 439 85  HOH HOH A . 
D 3 HOH 140 440 231 HOH HOH A . 
D 3 HOH 141 441 280 HOH HOH A . 
D 3 HOH 142 442 223 HOH HOH A . 
D 3 HOH 143 443 44  HOH HOH A . 
D 3 HOH 144 444 146 HOH HOH A . 
D 3 HOH 145 445 241 HOH HOH A . 
D 3 HOH 146 446 293 HOH HOH A . 
D 3 HOH 147 447 200 HOH HOH A . 
D 3 HOH 148 448 72  HOH HOH A . 
D 3 HOH 149 449 62  HOH HOH A . 
D 3 HOH 150 450 29  HOH HOH A . 
D 3 HOH 151 451 213 HOH HOH A . 
D 3 HOH 152 452 26  HOH HOH A . 
D 3 HOH 153 453 335 HOH HOH A . 
D 3 HOH 154 454 165 HOH HOH A . 
D 3 HOH 155 455 284 HOH HOH A . 
D 3 HOH 156 456 113 HOH HOH A . 
D 3 HOH 157 457 238 HOH HOH A . 
D 3 HOH 158 458 82  HOH HOH A . 
D 3 HOH 159 459 110 HOH HOH A . 
D 3 HOH 160 460 306 HOH HOH A . 
D 3 HOH 161 461 137 HOH HOH A . 
D 3 HOH 162 462 277 HOH HOH A . 
D 3 HOH 163 463 263 HOH HOH A . 
D 3 HOH 164 464 169 HOH HOH A . 
D 3 HOH 165 465 232 HOH HOH A . 
D 3 HOH 166 466 245 HOH HOH A . 
D 3 HOH 167 467 270 HOH HOH A . 
D 3 HOH 168 468 174 HOH HOH A . 
D 3 HOH 169 469 247 HOH HOH A . 
D 3 HOH 170 470 148 HOH HOH A . 
D 3 HOH 171 471 324 HOH HOH A . 
D 3 HOH 172 472 340 HOH HOH A . 
D 3 HOH 173 473 278 HOH HOH A . 
D 3 HOH 174 474 326 HOH HOH A . 
D 3 HOH 175 475 294 HOH HOH A . 
D 3 HOH 176 476 334 HOH HOH A . 
D 3 HOH 177 477 27  HOH HOH A . 
D 3 HOH 178 478 276 HOH HOH A . 
D 3 HOH 179 479 192 HOH HOH A . 
D 3 HOH 180 480 98  HOH HOH A . 
D 3 HOH 181 481 127 HOH HOH A . 
D 3 HOH 182 482 252 HOH HOH A . 
D 3 HOH 183 483 159 HOH HOH A . 
D 3 HOH 184 484 274 HOH HOH A . 
D 3 HOH 185 485 281 HOH HOH A . 
D 3 HOH 186 486 175 HOH HOH A . 
D 3 HOH 187 487 343 HOH HOH A . 
D 3 HOH 188 488 167 HOH HOH A . 
D 3 HOH 189 489 187 HOH HOH A . 
D 3 HOH 190 490 209 HOH HOH A . 
D 3 HOH 191 491 292 HOH HOH A . 
D 3 HOH 192 492 273 HOH HOH A . 
D 3 HOH 193 493 257 HOH HOH A . 
D 3 HOH 194 494 152 HOH HOH A . 
D 3 HOH 195 495 207 HOH HOH A . 
E 3 HOH 1   401 154 HOH HOH B . 
E 3 HOH 2   402 224 HOH HOH B . 
E 3 HOH 3   403 253 HOH HOH B . 
E 3 HOH 4   404 75  HOH HOH B . 
E 3 HOH 5   405 37  HOH HOH B . 
E 3 HOH 6   406 126 HOH HOH B . 
E 3 HOH 7   407 8   HOH HOH B . 
E 3 HOH 8   408 323 HOH HOH B . 
E 3 HOH 9   409 242 HOH HOH B . 
E 3 HOH 10  410 228 HOH HOH B . 
E 3 HOH 11  411 160 HOH HOH B . 
E 3 HOH 12  412 33  HOH HOH B . 
E 3 HOH 13  413 275 HOH HOH B . 
E 3 HOH 14  414 203 HOH HOH B . 
E 3 HOH 15  415 78  HOH HOH B . 
E 3 HOH 16  416 46  HOH HOH B . 
E 3 HOH 17  417 136 HOH HOH B . 
E 3 HOH 18  418 182 HOH HOH B . 
E 3 HOH 19  419 47  HOH HOH B . 
E 3 HOH 20  420 339 HOH HOH B . 
E 3 HOH 21  421 214 HOH HOH B . 
E 3 HOH 22  422 320 HOH HOH B . 
E 3 HOH 23  423 117 HOH HOH B . 
E 3 HOH 24  424 319 HOH HOH B . 
E 3 HOH 25  425 162 HOH HOH B . 
E 3 HOH 26  426 251 HOH HOH B . 
E 3 HOH 27  427 96  HOH HOH B . 
E 3 HOH 28  428 50  HOH HOH B . 
E 3 HOH 29  429 181 HOH HOH B . 
E 3 HOH 30  430 28  HOH HOH B . 
E 3 HOH 31  431 23  HOH HOH B . 
E 3 HOH 32  432 120 HOH HOH B . 
E 3 HOH 33  433 68  HOH HOH B . 
E 3 HOH 34  434 3   HOH HOH B . 
E 3 HOH 35  435 111 HOH HOH B . 
E 3 HOH 36  436 88  HOH HOH B . 
E 3 HOH 37  437 341 HOH HOH B . 
E 3 HOH 38  438 99  HOH HOH B . 
E 3 HOH 39  439 172 HOH HOH B . 
E 3 HOH 40  440 333 HOH HOH B . 
E 3 HOH 41  441 19  HOH HOH B . 
E 3 HOH 42  442 199 HOH HOH B . 
E 3 HOH 43  443 11  HOH HOH B . 
E 3 HOH 44  444 313 HOH HOH B . 
E 3 HOH 45  445 34  HOH HOH B . 
E 3 HOH 46  446 312 HOH HOH B . 
E 3 HOH 47  447 166 HOH HOH B . 
E 3 HOH 48  448 57  HOH HOH B . 
E 3 HOH 49  449 12  HOH HOH B . 
E 3 HOH 50  450 190 HOH HOH B . 
E 3 HOH 51  451 10  HOH HOH B . 
E 3 HOH 52  452 42  HOH HOH B . 
E 3 HOH 53  453 122 HOH HOH B . 
E 3 HOH 54  454 106 HOH HOH B . 
E 3 HOH 55  455 194 HOH HOH B . 
E 3 HOH 56  456 322 HOH HOH B . 
E 3 HOH 57  457 259 HOH HOH B . 
E 3 HOH 58  458 198 HOH HOH B . 
E 3 HOH 59  459 43  HOH HOH B . 
E 3 HOH 60  460 14  HOH HOH B . 
E 3 HOH 61  461 235 HOH HOH B . 
E 3 HOH 62  462 119 HOH HOH B . 
E 3 HOH 63  463 135 HOH HOH B . 
E 3 HOH 64  464 211 HOH HOH B . 
E 3 HOH 65  465 100 HOH HOH B . 
E 3 HOH 66  466 244 HOH HOH B . 
E 3 HOH 67  467 330 HOH HOH B . 
E 3 HOH 68  468 188 HOH HOH B . 
E 3 HOH 69  469 204 HOH HOH B . 
E 3 HOH 70  470 93  HOH HOH B . 
E 3 HOH 71  471 1   HOH HOH B . 
E 3 HOH 72  472 314 HOH HOH B . 
E 3 HOH 73  473 233 HOH HOH B . 
E 3 HOH 74  474 304 HOH HOH B . 
E 3 HOH 75  475 9   HOH HOH B . 
E 3 HOH 76  476 80  HOH HOH B . 
E 3 HOH 77  477 18  HOH HOH B . 
E 3 HOH 78  478 31  HOH HOH B . 
E 3 HOH 79  479 133 HOH HOH B . 
E 3 HOH 80  480 118 HOH HOH B . 
E 3 HOH 81  481 86  HOH HOH B . 
E 3 HOH 82  482 130 HOH HOH B . 
E 3 HOH 83  483 256 HOH HOH B . 
E 3 HOH 84  484 208 HOH HOH B . 
E 3 HOH 85  485 225 HOH HOH B . 
E 3 HOH 86  486 307 HOH HOH B . 
E 3 HOH 87  487 77  HOH HOH B . 
E 3 HOH 88  488 55  HOH HOH B . 
E 3 HOH 89  489 147 HOH HOH B . 
E 3 HOH 90  490 338 HOH HOH B . 
E 3 HOH 91  491 101 HOH HOH B . 
E 3 HOH 92  492 20  HOH HOH B . 
E 3 HOH 93  493 116 HOH HOH B . 
E 3 HOH 94  494 249 HOH HOH B . 
E 3 HOH 95  495 134 HOH HOH B . 
E 3 HOH 96  496 131 HOH HOH B . 
E 3 HOH 97  497 139 HOH HOH B . 
E 3 HOH 98  498 216 HOH HOH B . 
E 3 HOH 99  499 310 HOH HOH B . 
E 3 HOH 100 500 201 HOH HOH B . 
E 3 HOH 101 501 81  HOH HOH B . 
E 3 HOH 102 502 291 HOH HOH B . 
E 3 HOH 103 503 219 HOH HOH B . 
E 3 HOH 104 504 170 HOH HOH B . 
E 3 HOH 105 505 329 HOH HOH B . 
E 3 HOH 106 506 227 HOH HOH B . 
E 3 HOH 107 507 142 HOH HOH B . 
E 3 HOH 108 508 301 HOH HOH B . 
E 3 HOH 109 509 40  HOH HOH B . 
E 3 HOH 110 510 254 HOH HOH B . 
E 3 HOH 111 511 285 HOH HOH B . 
E 3 HOH 112 512 250 HOH HOH B . 
E 3 HOH 113 513 144 HOH HOH B . 
E 3 HOH 114 514 261 HOH HOH B . 
E 3 HOH 115 515 155 HOH HOH B . 
E 3 HOH 116 516 149 HOH HOH B . 
E 3 HOH 117 517 64  HOH HOH B . 
E 3 HOH 118 518 236 HOH HOH B . 
E 3 HOH 119 519 168 HOH HOH B . 
E 3 HOH 120 520 102 HOH HOH B . 
E 3 HOH 121 521 157 HOH HOH B . 
E 3 HOH 122 522 217 HOH HOH B . 
E 3 HOH 123 523 272 HOH HOH B . 
E 3 HOH 124 524 337 HOH HOH B . 
E 3 HOH 125 525 63  HOH HOH B . 
E 3 HOH 126 526 185 HOH HOH B . 
E 3 HOH 127 527 287 HOH HOH B . 
E 3 HOH 128 528 61  HOH HOH B . 
E 3 HOH 129 529 299 HOH HOH B . 
E 3 HOH 130 530 282 HOH HOH B . 
E 3 HOH 131 531 191 HOH HOH B . 
E 3 HOH 132 532 239 HOH HOH B . 
E 3 HOH 133 533 248 HOH HOH B . 
E 3 HOH 134 534 128 HOH HOH B . 
E 3 HOH 135 535 141 HOH HOH B . 
E 3 HOH 136 536 95  HOH HOH B . 
E 3 HOH 137 537 311 HOH HOH B . 
E 3 HOH 138 538 246 HOH HOH B . 
E 3 HOH 139 539 288 HOH HOH B . 
E 3 HOH 140 540 342 HOH HOH B . 
E 3 HOH 141 541 210 HOH HOH B . 
E 3 HOH 142 542 289 HOH HOH B . 
E 3 HOH 143 543 212 HOH HOH B . 
E 3 HOH 144 544 220 HOH HOH B . 
E 3 HOH 145 545 296 HOH HOH B . 
E 3 HOH 146 546 325 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A MET 49  ? CG  ? A MET 47  CG  
2   1 Y 1 A MET 49  ? SD  ? A MET 47  SD  
3   1 Y 1 A MET 49  ? CE  ? A MET 47  CE  
4   1 Y 1 A ASN 72  ? CG  ? A ASN 70  CG  
5   1 Y 1 A ASN 72  ? OD1 ? A ASN 70  OD1 
6   1 Y 1 A ASN 72  ? ND2 ? A ASN 70  ND2 
7   1 Y 1 A GLN 74  ? CG  ? A GLN 72  CG  
8   1 Y 1 A GLN 74  ? CD  ? A GLN 72  CD  
9   1 Y 1 A GLN 74  ? OE1 ? A GLN 72  OE1 
10  1 Y 1 A GLN 74  ? NE2 ? A GLN 72  NE2 
11  1 Y 1 A ARG 76  ? CG  ? A ARG 74  CG  
12  1 Y 1 A ARG 76  ? CD  ? A ARG 74  CD  
13  1 Y 1 A ARG 76  ? NE  ? A ARG 74  NE  
14  1 Y 1 A ARG 76  ? CZ  ? A ARG 74  CZ  
15  1 Y 1 A ARG 76  ? NH1 ? A ARG 74  NH1 
16  1 Y 1 A ARG 76  ? NH2 ? A ARG 74  NH2 
17  1 Y 1 A VAL 77  ? CG1 ? A VAL 75  CG1 
18  1 Y 1 A VAL 77  ? CG2 ? A VAL 75  CG2 
19  1 Y 1 A LYS 100 ? CG  ? A LYS 98  CG  
20  1 Y 1 A LYS 100 ? CD  ? A LYS 98  CD  
21  1 Y 1 A LYS 100 ? CE  ? A LYS 98  CE  
22  1 Y 1 A LYS 100 ? NZ  ? A LYS 98  NZ  
23  1 Y 1 A TYR 118 ? CG  ? A TYR 116 CG  
24  1 Y 1 A TYR 118 ? CD1 ? A TYR 116 CD1 
25  1 Y 1 A TYR 118 ? CD2 ? A TYR 116 CD2 
26  1 Y 1 A TYR 118 ? CE1 ? A TYR 116 CE1 
27  1 Y 1 A TYR 118 ? CE2 ? A TYR 116 CE2 
28  1 Y 1 A TYR 118 ? CZ  ? A TYR 116 CZ  
29  1 Y 1 A TYR 118 ? OH  ? A TYR 116 OH  
30  1 Y 1 A ASN 119 ? CG  ? A ASN 117 CG  
31  1 Y 1 A ASN 119 ? OD1 ? A ASN 117 OD1 
32  1 Y 1 A ASN 119 ? ND2 ? A ASN 117 ND2 
33  1 Y 1 A LYS 137 ? CG  ? A LYS 135 CG  
34  1 Y 1 A LYS 137 ? CD  ? A LYS 135 CD  
35  1 Y 1 A LYS 137 ? CE  ? A LYS 135 CE  
36  1 Y 1 A LYS 137 ? NZ  ? A LYS 135 NZ  
37  1 Y 1 A TYR 154 ? CG  ? A TYR 152 CG  
38  1 Y 1 A TYR 154 ? CD1 ? A TYR 152 CD1 
39  1 Y 1 A TYR 154 ? CD2 ? A TYR 152 CD2 
40  1 Y 1 A TYR 154 ? CE1 ? A TYR 152 CE1 
41  1 Y 1 A TYR 154 ? CE2 ? A TYR 152 CE2 
42  1 Y 1 A TYR 154 ? CZ  ? A TYR 152 CZ  
43  1 Y 1 A TYR 154 ? OH  ? A TYR 152 OH  
44  1 Y 1 A GLU 166 ? CG  ? A GLU 164 CG  
45  1 Y 1 A GLU 166 ? CD  ? A GLU 164 CD  
46  1 Y 1 A GLU 166 ? OE1 ? A GLU 164 OE1 
47  1 Y 1 A GLU 166 ? OE2 ? A GLU 164 OE2 
48  1 Y 1 A ARG 298 ? CG  ? A ARG 296 CG  
49  1 Y 1 A ARG 298 ? CD  ? A ARG 296 CD  
50  1 Y 1 A ARG 298 ? NE  ? A ARG 296 NE  
51  1 Y 1 A ARG 298 ? CZ  ? A ARG 296 CZ  
52  1 Y 1 A ARG 298 ? NH1 ? A ARG 296 NH1 
53  1 Y 1 A ARG 298 ? NH2 ? A ARG 296 NH2 
54  1 Y 1 B MET 49  ? CG  ? B MET 47  CG  
55  1 Y 1 B MET 49  ? SD  ? B MET 47  SD  
56  1 Y 1 B MET 49  ? CE  ? B MET 47  CE  
57  1 Y 1 B ASN 72  ? CG  ? B ASN 70  CG  
58  1 Y 1 B ASN 72  ? OD1 ? B ASN 70  OD1 
59  1 Y 1 B ASN 72  ? ND2 ? B ASN 70  ND2 
60  1 Y 1 B GLN 74  ? CG  ? B GLN 72  CG  
61  1 Y 1 B GLN 74  ? CD  ? B GLN 72  CD  
62  1 Y 1 B GLN 74  ? OE1 ? B GLN 72  OE1 
63  1 Y 1 B GLN 74  ? NE2 ? B GLN 72  NE2 
64  1 Y 1 B ARG 76  ? CG  ? B ARG 74  CG  
65  1 Y 1 B ARG 76  ? CD  ? B ARG 74  CD  
66  1 Y 1 B ARG 76  ? NE  ? B ARG 74  NE  
67  1 Y 1 B ARG 76  ? CZ  ? B ARG 74  CZ  
68  1 Y 1 B ARG 76  ? NH1 ? B ARG 74  NH1 
69  1 Y 1 B ARG 76  ? NH2 ? B ARG 74  NH2 
70  1 Y 1 B VAL 77  ? CG1 ? B VAL 75  CG1 
71  1 Y 1 B VAL 77  ? CG2 ? B VAL 75  CG2 
72  1 Y 1 B LYS 100 ? CG  ? B LYS 98  CG  
73  1 Y 1 B LYS 100 ? CD  ? B LYS 98  CD  
74  1 Y 1 B LYS 100 ? CE  ? B LYS 98  CE  
75  1 Y 1 B LYS 100 ? NZ  ? B LYS 98  NZ  
76  1 Y 1 B LYS 102 ? CG  ? B LYS 100 CG  
77  1 Y 1 B LYS 102 ? CD  ? B LYS 100 CD  
78  1 Y 1 B LYS 102 ? CE  ? B LYS 100 CE  
79  1 Y 1 B LYS 102 ? NZ  ? B LYS 100 NZ  
80  1 Y 1 B TYR 118 ? CG  ? B TYR 116 CG  
81  1 Y 1 B TYR 118 ? CD1 ? B TYR 116 CD1 
82  1 Y 1 B TYR 118 ? CD2 ? B TYR 116 CD2 
83  1 Y 1 B TYR 118 ? CE1 ? B TYR 116 CE1 
84  1 Y 1 B TYR 118 ? CE2 ? B TYR 116 CE2 
85  1 Y 1 B TYR 118 ? CZ  ? B TYR 116 CZ  
86  1 Y 1 B TYR 118 ? OH  ? B TYR 116 OH  
87  1 Y 1 B LYS 137 ? CG  ? B LYS 135 CG  
88  1 Y 1 B LYS 137 ? CD  ? B LYS 135 CD  
89  1 Y 1 B LYS 137 ? CE  ? B LYS 135 CE  
90  1 Y 1 B LYS 137 ? NZ  ? B LYS 135 NZ  
91  1 Y 1 B TYR 154 ? CG  ? B TYR 152 CG  
92  1 Y 1 B TYR 154 ? CD1 ? B TYR 152 CD1 
93  1 Y 1 B TYR 154 ? CD2 ? B TYR 152 CD2 
94  1 Y 1 B TYR 154 ? CE1 ? B TYR 152 CE1 
95  1 Y 1 B TYR 154 ? CE2 ? B TYR 152 CE2 
96  1 Y 1 B TYR 154 ? CZ  ? B TYR 152 CZ  
97  1 Y 1 B TYR 154 ? OH  ? B TYR 152 OH  
98  1 Y 1 B GLU 166 ? CG  ? B GLU 164 CG  
99  1 Y 1 B GLU 166 ? CD  ? B GLU 164 CD  
100 1 Y 1 B GLU 166 ? OE1 ? B GLU 164 OE1 
101 1 Y 1 B GLU 166 ? OE2 ? B GLU 164 OE2 
102 1 Y 1 B GLN 189 ? CG  ? B GLN 187 CG  
103 1 Y 1 B GLN 189 ? CD  ? B GLN 187 CD  
104 1 Y 1 B GLN 189 ? OE1 ? B GLN 187 OE1 
105 1 Y 1 B GLN 189 ? NE2 ? B GLN 187 NE2 
106 1 Y 1 B MET 235 ? CG  ? B MET 233 CG  
107 1 Y 1 B MET 235 ? SD  ? B MET 233 SD  
108 1 Y 1 B MET 235 ? CE  ? B MET 233 CE  
109 1 Y 1 B ARG 298 ? CG  ? B ARG 296 CG  
110 1 Y 1 B ARG 298 ? CD  ? B ARG 296 CD  
111 1 Y 1 B ARG 298 ? NE  ? B ARG 296 NE  
112 1 Y 1 B ARG 298 ? CZ  ? B ARG 296 CZ  
113 1 Y 1 B ARG 298 ? NH1 ? B ARG 296 NH1 
114 1 Y 1 B ARG 298 ? NH2 ? B ARG 296 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.12_2829 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YWZ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     67.830 
_cell.length_a_esd                 ? 
_cell.length_b                     102.800 
_cell.length_b_esd                 ? 
_cell.length_c                     102.980 
_cell.length_c_esd                 ? 
_cell.volume                       718071.714 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YWZ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YWZ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.74 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.16 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1M Na2SO4,24% PEG3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-01-24 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979183 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL10U2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979183 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL10U2 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          31.276058558 
_reflns.entry_id                                       8YWZ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.91 
_reflns.d_resolution_low                               32.06 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     56046 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.1 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.152 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.91 
_reflns_shell.d_res_low                                     1.96 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3684 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.052 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               36.104413292 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YWZ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.91 
_refine.ls_d_res_low                             30.63 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     55952 
_refine.ls_number_reflns_R_free                  2681 
_refine.ls_number_reflns_R_work                  53271 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.9337812749 
_refine.ls_percent_reflns_R_free                 4.79160709179 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.197518073126 
_refine.ls_R_factor_R_free                       0.232867024595 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.195766620685 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34365260334 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 24.173844064 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.227215478089 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.91 
_refine_hist.d_res_low                        30.63 
_refine_hist.number_atoms_solvent             341 
_refine_hist.number_atoms_total               4840 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4466 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         33 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.00669582689047 ? 4601 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.863852042439   ? 6271 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0523306070274  ? 724  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.00549309329876 ? 814  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.53642561457    ? 2685 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.91   1.9447 . . 133 2444 87.6828853351 . . . . 0.294897162511 . . . . . . . . . . . 0.349400370305 
'X-RAY DIFFRACTION' 1.9447 1.9821 . . 154 2654 94.7048903879 . . . . 0.26329245687  . . . . . . . . . . . 0.28232771902  
'X-RAY DIFFRACTION' 1.9821 2.0226 . . 155 2732 99.2437263664 . . . . 0.246166262092 . . . . . . . . . . . 0.276715659537 
'X-RAY DIFFRACTION' 2.0226 2.0666 . . 126 2800 99.7613365155 . . . . 0.224586367618 . . . . . . . . . . . 0.247026051694 
'X-RAY DIFFRACTION' 2.0666 2.1146 . . 132 2798 99.8636673483 . . . . 0.223039291912 . . . . . . . . . . . 0.261731263839 
'X-RAY DIFFRACTION' 2.1146 2.1675 . . 118 2827 99.729089062  . . . . 0.216910168897 . . . . . . . . . . . 0.257323831347 
'X-RAY DIFFRACTION' 2.1675 2.2261 . . 129 2790 99.9315302978 . . . . 0.220038367673 . . . . . . . . . . . 0.258823048321 
'X-RAY DIFFRACTION' 2.2261 2.2916 . . 150 2815 99.9662845583 . . . . 0.219152733295 . . . . . . . . . . . 0.255511710139 
'X-RAY DIFFRACTION' 2.2916 2.3655 . . 142 2806 99.8983395459 . . . . 0.211067411735 . . . . . . . . . . . 0.25360079594  
'X-RAY DIFFRACTION' 2.3655 2.45   . . 149 2810 99.9662162162 . . . . 0.212250975389 . . . . . . . . . . . 0.269353047028 
'X-RAY DIFFRACTION' 2.45   2.548  . . 129 2824 99.9661475965 . . . . 0.208812610148 . . . . . . . . . . . 0.305058224459 
'X-RAY DIFFRACTION' 2.548  2.664  . . 159 2792 99.9661246612 . . . . 0.205156468412 . . . . . . . . . . . 0.277356430663 
'X-RAY DIFFRACTION' 2.664  2.8043 . . 168 2815 99.9664879357 . . . . 0.207499469009 . . . . . . . . . . . 0.265841893041 
'X-RAY DIFFRACTION' 2.8043 2.9799 . . 149 2828 99.9664204164 . . . . 0.200788963368 . . . . . . . . . . . 0.234898572938 
'X-RAY DIFFRACTION' 2.9799 3.2097 . . 144 2855 99.9666666667 . . . . 0.201021571759 . . . . . . . . . . . 0.261754657578 
'X-RAY DIFFRACTION' 3.2097 3.5323 . . 145 2853 99.9666555519 . . . . 0.191519964981 . . . . . . . . . . . 0.234236205419 
'X-RAY DIFFRACTION' 3.5323 4.0424 . . 138 2870 99.9335548173 . . . . 0.180617483808 . . . . . . . . . . . 0.187068836006 
'X-RAY DIFFRACTION' 4.0424 5.0893 . . 151 2889 99.8357963875 . . . . 0.154495029738 . . . . . . . . . . . 0.175189729773 
'X-RAY DIFFRACTION' 5.0893 30.63  . . 110 3069 99.34375      . . . . 0.188920635289 . . . . . . . . . . . 0.225439421758 
# 
_struct.entry_id                     8YWZ 
_struct.title                        'Crystal structure of SARS-Cov-2 main protease H163A mutant in complex with Bofutrelvir' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YWZ 
_struct_keywords.text            'VIRAL PROTEIN-INHIBITOR COMPLEX, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;FRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSM
QNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYM
HHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPL
TQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVR
;
_struct_ref.pdbx_align_begin           3266 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YWZ A 1 ? 296 ? P0DTD1 3266 ? 3561 ? 3 298 
2 1 8YWZ B 1 ? 296 ? P0DTD1 3266 ? 3561 ? 3 298 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YWZ ALA A 140 ? UNP P0DTD1 ASN 3405 conflict              142 1 
1 8YWZ ALA A 161 ? UNP P0DTD1 HIS 3426 'engineered mutation' 163 2 
2 8YWZ ALA B 140 ? UNP P0DTD1 ASN 3405 conflict              142 3 
2 8YWZ ALA B 161 ? UNP P0DTD1 HIS 3426 'engineered mutation' 163 4 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1870  ? 
1 MORE         -10   ? 
1 'SSA (A^2)'  25460 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 8   ? GLY A 13  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 39  ? CYS A 42  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 THR A 43  ? MET A 47  ? THR A 45  MET A 49  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 51  ? ARG A 58  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 60  ? HIS A 62  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 198 ? ASN A 212 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 224 ? MET A 233 ? THR A 226 MET A 235 1 ? 10 
HELX_P HELX_P8  AA8 LYS A 234 ? ASN A 236 ? LYS A 236 ASN A 238 5 ? 3  
HELX_P HELX_P9  AA9 THR A 241 ? LEU A 248 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P10 AB1 LEU A 248 ? GLY A 256 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P11 AB2 ALA A 258 ? GLY A 273 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P12 AB3 THR A 290 ? ARG A 296 ? THR A 292 ARG A 298 1 ? 7  
HELX_P HELX_P13 AB4 SER B 8   ? GLY B 13  ? SER B 10  GLY B 15  1 ? 6  
HELX_P HELX_P14 AB5 HIS B 39  ? CYS B 42  ? HIS B 41  CYS B 44  5 ? 4  
HELX_P HELX_P15 AB6 GLU B 45  ? ASN B 49  ? GLU B 47  ASN B 51  5 ? 5  
HELX_P HELX_P16 AB7 ASN B 51  ? ARG B 58  ? ASN B 53  ARG B 60  1 ? 8  
HELX_P HELX_P17 AB8 SER B 60  ? HIS B 62  ? SER B 62  HIS B 64  5 ? 3  
HELX_P HELX_P18 AB9 ILE B 198 ? ASN B 212 ? ILE B 200 ASN B 214 1 ? 15 
HELX_P HELX_P19 AC1 THR B 224 ? TYR B 235 ? THR B 226 TYR B 237 1 ? 12 
HELX_P HELX_P20 AC2 THR B 241 ? LEU B 248 ? THR B 243 LEU B 250 1 ? 8  
HELX_P HELX_P21 AC3 LEU B 248 ? GLY B 256 ? LEU B 250 GLY B 258 1 ? 9  
HELX_P HELX_P22 AC4 ALA B 258 ? GLY B 273 ? ALA B 260 GLY B 275 1 ? 16 
HELX_P HELX_P23 AC5 THR B 290 ? ARG B 296 ? THR B 292 ARG B 298 1 ? 7  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           B 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            143 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           C 
_struct_conn.ptnr2_label_comp_id           FHR 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C31 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            B 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            B 
_struct_conn.ptnr2_auth_comp_id            FHR 
_struct_conn.ptnr2_auth_seq_id             301 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.770 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      FHR 
_pdbx_modification_feature.label_asym_id                      C 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     B 
_pdbx_modification_feature.modified_residue_label_seq_id      143 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       FHR 
_pdbx_modification_feature.auth_asym_id                       B 
_pdbx_modification_feature.auth_seq_id                        301 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      B 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C31 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        FHR 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 7 ? 
AA5 ? 5 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 71  ? LEU A 73  ? VAL A 73  LEU A 75  
AA1 2 PHE A 64  ? ALA A 68  ? PHE A 66  ALA A 70  
AA1 3 MET A 15  ? CYS A 20  ? MET A 17  CYS A 22  
AA1 4 THR A 23  ? LEU A 30  ? THR A 25  LEU A 32  
AA1 5 VAL A 33  ? PRO A 37  ? VAL A 35  PRO A 39  
AA1 6 VAL A 84  ? VAL A 89  ? VAL A 86  VAL A 91  
AA1 7 VAL A 75  ? GLN A 81  ? VAL A 77  GLN A 83  
AA2 1 LYS A 98  ? PHE A 101 ? LYS A 100 PHE A 103 
AA2 2 CYS A 154 ? GLU A 164 ? CYS A 156 GLU A 166 
AA2 3 VAL A 146 ? ASP A 151 ? VAL A 148 ASP A 153 
AA2 4 THR A 109 ? TYR A 116 ? THR A 111 TYR A 118 
AA2 5 SER A 119 ? ALA A 127 ? SER A 121 ALA A 129 
AA3 1 LYS A 98  ? PHE A 101 ? LYS A 100 PHE A 103 
AA3 2 CYS A 154 ? GLU A 164 ? CYS A 156 GLU A 166 
AA3 3 HIS A 170 ? THR A 173 ? HIS A 172 THR A 175 
AA4 1 VAL B 71  ? LEU B 73  ? VAL B 73  LEU B 75  
AA4 2 PHE B 64  ? ALA B 68  ? PHE B 66  ALA B 70  
AA4 3 MET B 15  ? CYS B 20  ? MET B 17  CYS B 22  
AA4 4 THR B 23  ? LEU B 30  ? THR B 25  LEU B 32  
AA4 5 VAL B 33  ? PRO B 37  ? VAL B 35  PRO B 39  
AA4 6 VAL B 84  ? VAL B 89  ? VAL B 86  VAL B 91  
AA4 7 VAL B 75  ? GLN B 81  ? VAL B 77  GLN B 83  
AA5 1 LYS B 98  ? PHE B 101 ? LYS B 100 PHE B 103 
AA5 2 CYS B 154 ? GLU B 164 ? CYS B 156 GLU B 166 
AA5 3 VAL B 146 ? ASP B 151 ? VAL B 148 ASP B 153 
AA5 4 THR B 109 ? TYR B 116 ? THR B 111 TYR B 118 
AA5 5 SER B 119 ? ALA B 127 ? SER B 121 ALA B 129 
AA6 1 LYS B 98  ? PHE B 101 ? LYS B 100 PHE B 103 
AA6 2 CYS B 154 ? GLU B 164 ? CYS B 156 GLU B 166 
AA6 3 HIS B 170 ? THR B 173 ? HIS B 172 THR B 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 71  ? O VAL A 73  N ALA A 68  ? N ALA A 70  
AA1 2 3 O LEU A 65  ? O LEU A 67  N THR A 19  ? N THR A 21  
AA1 3 4 N VAL A 18  ? N VAL A 20  O LEU A 25  ? O LEU A 27  
AA1 4 5 N LEU A 28  ? N LEU A 30  O TYR A 35  ? O TYR A 37  
AA1 5 6 N CYS A 36  ? N CYS A 38  O LEU A 85  ? O LEU A 87  
AA1 6 7 O LYS A 86  ? O LYS A 88  N SER A 79  ? N SER A 81  
AA2 1 2 N LYS A 98  ? N LYS A 100 O VAL A 155 ? O VAL A 157 
AA2 2 3 O SER A 156 ? O SER A 158 N ASN A 149 ? N ASN A 151 
AA2 3 4 O PHE A 148 ? O PHE A 150 N SER A 111 ? N SER A 113 
AA2 4 5 N ALA A 114 ? N ALA A 116 O SER A 121 ? O SER A 123 
AA3 1 2 N LYS A 98  ? N LYS A 100 O VAL A 155 ? O VAL A 157 
AA3 2 3 N MET A 163 ? N MET A 165 O ALA A 171 ? O ALA A 173 
AA4 1 2 O LEU B 73  ? O LEU B 75  N VAL B 66  ? N VAL B 68  
AA4 2 3 O LEU B 65  ? O LEU B 67  N THR B 19  ? N THR B 21  
AA4 3 4 N VAL B 18  ? N VAL B 20  O LEU B 25  ? O LEU B 27  
AA4 4 5 N LEU B 28  ? N LEU B 30  O TYR B 35  ? O TYR B 37  
AA4 5 6 N CYS B 36  ? N CYS B 38  O LEU B 85  ? O LEU B 87  
AA4 6 7 O LYS B 86  ? O LYS B 88  N SER B 79  ? N SER B 81  
AA5 1 2 N LYS B 98  ? N LYS B 100 O VAL B 155 ? O VAL B 157 
AA5 2 3 O SER B 156 ? O SER B 158 N ASN B 149 ? N ASN B 151 
AA5 3 4 O PHE B 148 ? O PHE B 150 N SER B 111 ? N SER B 113 
AA5 4 5 N ALA B 114 ? N ALA B 116 O SER B 121 ? O SER B 123 
AA6 1 2 N LYS B 98  ? N LYS B 100 O VAL B 155 ? O VAL B 157 
AA6 2 3 N HIS B 162 ? N HIS B 164 O ALA B 171 ? O ALA B 173 
# 
_pdbx_entry_details.entry_id                   8YWZ 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OE2 A GLU 290 ? ? O A HOH 301 ? ? 2.14 
2 1 O   B HOH 543 ? ? O B HOH 544 ? ? 2.16 
3 1 O   B HOH 405 ? ? O B HOH 530 ? ? 2.16 
4 1 O   B HOH 401 ? ? O B HOH 509 ? ? 2.17 
5 1 O   A HOH 393 ? ? O B HOH 537 ? ? 2.18 
6 1 O   B HOH 539 ? ? O B HOH 542 ? ? 2.18 
7 1 O   B HOH 515 ? ? O B HOH 530 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     434 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     492 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_554 
_pdbx_validate_symm_contact.dist              2.12 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_1              187 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_2              187 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             OD1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_3              187 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                123.74 
_pdbx_validate_rmsd_angle.angle_target_value         118.30 
_pdbx_validate_rmsd_angle.angle_deviation            5.44 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.90 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 57.08   -128.46 
2 1 ASN A 84  ? ? 52.33   -121.81 
3 1 LEU A 141 ? ? -41.85  155.15  
4 1 ARG A 217 ? ? -143.08 -2.35   
5 1 ASP B 33  ? ? 55.28   -132.82 
6 1 ASN B 84  ? ? 53.15   -125.19 
7 1 ASP B 155 ? ? 57.01   11.71   
8 1 LEU B 282 ? ? 47.81   -123.35 
# 
_pdbx_molecule_features.prd_id    PRD_002347 
_pdbx_molecule_features.name      
;~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide
;
_pdbx_molecule_features.type      Peptide-like 
_pdbx_molecule_features.class     Inhibitor 
_pdbx_molecule_features.details   ? 
# 
_pdbx_molecule.instance_id   1 
_pdbx_molecule.prd_id        PRD_002347 
_pdbx_molecule.asym_id       C 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      B 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       546 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.18 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
FHR C02  C N N 88  
FHR C07  C Y N 89  
FHR C08  C Y N 90  
FHR C09  C Y N 91  
FHR C10  C Y N 92  
FHR C05  C Y N 93  
FHR C06  C Y N 94  
FHR C04  C Y N 95  
FHR C03  C Y N 96  
FHR N11  N Y N 97  
FHR O01  O N N 98  
FHR N12  N N N 99  
FHR C13  C N S 100 
FHR C21  C N N 101 
FHR O33  O N N 102 
FHR C14  C N N 103 
FHR C15  C N N 104 
FHR C20  C N N 105 
FHR C19  C N N 106 
FHR C18  C N N 107 
FHR C17  C N N 108 
FHR C16  C N N 109 
FHR O30  O N N 110 
FHR C29  C N N 111 
FHR N28  N N N 112 
FHR C27  C N N 113 
FHR C26  C N N 114 
FHR C25  C N S 115 
FHR C24  C N N 116 
FHR C23  C N S 117 
FHR N22  N N N 118 
FHR C31  C N N 119 
FHR O32  O N N 120 
FHR H15  H N N 121 
FHR H16  H N N 122 
FHR H17  H N N 123 
FHR H14  H N N 124 
FHR H13  H N N 125 
FHR H32  H N N 126 
FHR H1   H N N 127 
FHR H2   H N N 128 
FHR H18  H N N 129 
FHR H19  H N N 130 
FHR H3   H N N 131 
FHR H7   H N N 132 
FHR H6   H N N 133 
FHR H25  H N N 134 
FHR H24  H N N 135 
FHR H23  H N N 136 
FHR H22  H N N 137 
FHR H5   H N N 138 
FHR H4   H N N 139 
FHR H20  H N N 140 
FHR H21  H N N 141 
FHR H34  H N N 142 
FHR H28  H N N 143 
FHR H29  H N N 144 
FHR H10  H N N 145 
FHR H11  H N N 146 
FHR H27  H N N 147 
FHR H9   H N N 148 
FHR H8   H N N 149 
FHR H26  H N N 150 
FHR H33  H N N 151 
FHR H31  H N N 152 
GLN N    N N N 153 
GLN CA   C N S 154 
GLN C    C N N 155 
GLN O    O N N 156 
GLN CB   C N N 157 
GLN CG   C N N 158 
GLN CD   C N N 159 
GLN OE1  O N N 160 
GLN NE2  N N N 161 
GLN OXT  O N N 162 
GLN H    H N N 163 
GLN H2   H N N 164 
GLN HA   H N N 165 
GLN HB2  H N N 166 
GLN HB3  H N N 167 
GLN HG2  H N N 168 
GLN HG3  H N N 169 
GLN HE21 H N N 170 
GLN HE22 H N N 171 
GLN HXT  H N N 172 
GLU N    N N N 173 
GLU CA   C N S 174 
GLU C    C N N 175 
GLU O    O N N 176 
GLU CB   C N N 177 
GLU CG   C N N 178 
GLU CD   C N N 179 
GLU OE1  O N N 180 
GLU OE2  O N N 181 
GLU OXT  O N N 182 
GLU H    H N N 183 
GLU H2   H N N 184 
GLU HA   H N N 185 
GLU HB2  H N N 186 
GLU HB3  H N N 187 
GLU HG2  H N N 188 
GLU HG3  H N N 189 
GLU HE2  H N N 190 
GLU HXT  H N N 191 
GLY N    N N N 192 
GLY CA   C N N 193 
GLY C    C N N 194 
GLY O    O N N 195 
GLY OXT  O N N 196 
GLY H    H N N 197 
GLY H2   H N N 198 
GLY HA2  H N N 199 
GLY HA3  H N N 200 
GLY HXT  H N N 201 
HIS N    N N N 202 
HIS CA   C N S 203 
HIS C    C N N 204 
HIS O    O N N 205 
HIS CB   C N N 206 
HIS CG   C Y N 207 
HIS ND1  N Y N 208 
HIS CD2  C Y N 209 
HIS CE1  C Y N 210 
HIS NE2  N Y N 211 
HIS OXT  O N N 212 
HIS H    H N N 213 
HIS H2   H N N 214 
HIS HA   H N N 215 
HIS HB2  H N N 216 
HIS HB3  H N N 217 
HIS HD1  H N N 218 
HIS HD2  H N N 219 
HIS HE1  H N N 220 
HIS HE2  H N N 221 
HIS HXT  H N N 222 
HOH O    O N N 223 
HOH H1   H N N 224 
HOH H2   H N N 225 
ILE N    N N N 226 
ILE CA   C N S 227 
ILE C    C N N 228 
ILE O    O N N 229 
ILE CB   C N S 230 
ILE CG1  C N N 231 
ILE CG2  C N N 232 
ILE CD1  C N N 233 
ILE OXT  O N N 234 
ILE H    H N N 235 
ILE H2   H N N 236 
ILE HA   H N N 237 
ILE HB   H N N 238 
ILE HG12 H N N 239 
ILE HG13 H N N 240 
ILE HG21 H N N 241 
ILE HG22 H N N 242 
ILE HG23 H N N 243 
ILE HD11 H N N 244 
ILE HD12 H N N 245 
ILE HD13 H N N 246 
ILE HXT  H N N 247 
LEU N    N N N 248 
LEU CA   C N S 249 
LEU C    C N N 250 
LEU O    O N N 251 
LEU CB   C N N 252 
LEU CG   C N N 253 
LEU CD1  C N N 254 
LEU CD2  C N N 255 
LEU OXT  O N N 256 
LEU H    H N N 257 
LEU H2   H N N 258 
LEU HA   H N N 259 
LEU HB2  H N N 260 
LEU HB3  H N N 261 
LEU HG   H N N 262 
LEU HD11 H N N 263 
LEU HD12 H N N 264 
LEU HD13 H N N 265 
LEU HD21 H N N 266 
LEU HD22 H N N 267 
LEU HD23 H N N 268 
LEU HXT  H N N 269 
LYS N    N N N 270 
LYS CA   C N S 271 
LYS C    C N N 272 
LYS O    O N N 273 
LYS CB   C N N 274 
LYS CG   C N N 275 
LYS CD   C N N 276 
LYS CE   C N N 277 
LYS NZ   N N N 278 
LYS OXT  O N N 279 
LYS H    H N N 280 
LYS H2   H N N 281 
LYS HA   H N N 282 
LYS HB2  H N N 283 
LYS HB3  H N N 284 
LYS HG2  H N N 285 
LYS HG3  H N N 286 
LYS HD2  H N N 287 
LYS HD3  H N N 288 
LYS HE2  H N N 289 
LYS HE3  H N N 290 
LYS HZ1  H N N 291 
LYS HZ2  H N N 292 
LYS HZ3  H N N 293 
LYS HXT  H N N 294 
MET N    N N N 295 
MET CA   C N S 296 
MET C    C N N 297 
MET O    O N N 298 
MET CB   C N N 299 
MET CG   C N N 300 
MET SD   S N N 301 
MET CE   C N N 302 
MET OXT  O N N 303 
MET H    H N N 304 
MET H2   H N N 305 
MET HA   H N N 306 
MET HB2  H N N 307 
MET HB3  H N N 308 
MET HG2  H N N 309 
MET HG3  H N N 310 
MET HE1  H N N 311 
MET HE2  H N N 312 
MET HE3  H N N 313 
MET HXT  H N N 314 
PHE N    N N N 315 
PHE CA   C N S 316 
PHE C    C N N 317 
PHE O    O N N 318 
PHE CB   C N N 319 
PHE CG   C Y N 320 
PHE CD1  C Y N 321 
PHE CD2  C Y N 322 
PHE CE1  C Y N 323 
PHE CE2  C Y N 324 
PHE CZ   C Y N 325 
PHE OXT  O N N 326 
PHE H    H N N 327 
PHE H2   H N N 328 
PHE HA   H N N 329 
PHE HB2  H N N 330 
PHE HB3  H N N 331 
PHE HD1  H N N 332 
PHE HD2  H N N 333 
PHE HE1  H N N 334 
PHE HE2  H N N 335 
PHE HZ   H N N 336 
PHE HXT  H N N 337 
PRO N    N N N 338 
PRO CA   C N S 339 
PRO C    C N N 340 
PRO O    O N N 341 
PRO CB   C N N 342 
PRO CG   C N N 343 
PRO CD   C N N 344 
PRO OXT  O N N 345 
PRO H    H N N 346 
PRO HA   H N N 347 
PRO HB2  H N N 348 
PRO HB3  H N N 349 
PRO HG2  H N N 350 
PRO HG3  H N N 351 
PRO HD2  H N N 352 
PRO HD3  H N N 353 
PRO HXT  H N N 354 
SER N    N N N 355 
SER CA   C N S 356 
SER C    C N N 357 
SER O    O N N 358 
SER CB   C N N 359 
SER OG   O N N 360 
SER OXT  O N N 361 
SER H    H N N 362 
SER H2   H N N 363 
SER HA   H N N 364 
SER HB2  H N N 365 
SER HB3  H N N 366 
SER HG   H N N 367 
SER HXT  H N N 368 
THR N    N N N 369 
THR CA   C N S 370 
THR C    C N N 371 
THR O    O N N 372 
THR CB   C N R 373 
THR OG1  O N N 374 
THR CG2  C N N 375 
THR OXT  O N N 376 
THR H    H N N 377 
THR H2   H N N 378 
THR HA   H N N 379 
THR HB   H N N 380 
THR HG1  H N N 381 
THR HG21 H N N 382 
THR HG22 H N N 383 
THR HG23 H N N 384 
THR HXT  H N N 385 
TRP N    N N N 386 
TRP CA   C N S 387 
TRP C    C N N 388 
TRP O    O N N 389 
TRP CB   C N N 390 
TRP CG   C Y N 391 
TRP CD1  C Y N 392 
TRP CD2  C Y N 393 
TRP NE1  N Y N 394 
TRP CE2  C Y N 395 
TRP CE3  C Y N 396 
TRP CZ2  C Y N 397 
TRP CZ3  C Y N 398 
TRP CH2  C Y N 399 
TRP OXT  O N N 400 
TRP H    H N N 401 
TRP H2   H N N 402 
TRP HA   H N N 403 
TRP HB2  H N N 404 
TRP HB3  H N N 405 
TRP HD1  H N N 406 
TRP HE1  H N N 407 
TRP HE3  H N N 408 
TRP HZ2  H N N 409 
TRP HZ3  H N N 410 
TRP HH2  H N N 411 
TRP HXT  H N N 412 
TYR N    N N N 413 
TYR CA   C N S 414 
TYR C    C N N 415 
TYR O    O N N 416 
TYR CB   C N N 417 
TYR CG   C Y N 418 
TYR CD1  C Y N 419 
TYR CD2  C Y N 420 
TYR CE1  C Y N 421 
TYR CE2  C Y N 422 
TYR CZ   C Y N 423 
TYR OH   O N N 424 
TYR OXT  O N N 425 
TYR H    H N N 426 
TYR H2   H N N 427 
TYR HA   H N N 428 
TYR HB2  H N N 429 
TYR HB3  H N N 430 
TYR HD1  H N N 431 
TYR HD2  H N N 432 
TYR HE1  H N N 433 
TYR HE2  H N N 434 
TYR HH   H N N 435 
TYR HXT  H N N 436 
VAL N    N N N 437 
VAL CA   C N S 438 
VAL C    C N N 439 
VAL O    O N N 440 
VAL CB   C N N 441 
VAL CG1  C N N 442 
VAL CG2  C N N 443 
VAL OXT  O N N 444 
VAL H    H N N 445 
VAL H2   H N N 446 
VAL HA   H N N 447 
VAL HB   H N N 448 
VAL HG11 H N N 449 
VAL HG12 H N N 450 
VAL HG13 H N N 451 
VAL HG21 H N N 452 
VAL HG22 H N N 453 
VAL HG23 H N N 454 
VAL HXT  H N N 455 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
FHR C10 C05  doub Y N 83  
FHR C10 C09  sing Y N 84  
FHR C10 N11  sing Y N 85  
FHR N12 C13  sing N N 86  
FHR N12 C02  sing N N 87  
FHR C13 C21  sing N N 88  
FHR C13 C14  sing N N 89  
FHR C15 C20  sing N N 90  
FHR C15 C14  sing N N 91  
FHR C15 C16  sing N N 92  
FHR C17 C16  sing N N 93  
FHR C17 C18  sing N N 94  
FHR C20 C19  sing N N 95  
FHR C21 N22  sing N N 96  
FHR C21 O33  doub N N 97  
FHR C24 C23  sing N N 98  
FHR C24 C25  sing N N 99  
FHR C26 C25  sing N N 100 
FHR C02 C03  sing N N 101 
FHR C02 O01  doub N N 102 
FHR C03 C04  doub Y N 103 
FHR C03 N11  sing Y N 104 
FHR C04 C05  sing Y N 105 
FHR C05 C06  sing Y N 106 
FHR C06 C07  doub Y N 107 
FHR C07 C08  sing Y N 108 
FHR C08 C09  doub Y N 109 
FHR C18 C19  sing N N 110 
FHR C23 C31  sing N N 111 
FHR C23 N22  sing N N 112 
FHR C25 C29  sing N N 113 
FHR C27 N28  sing N N 114 
FHR C29 N28  sing N N 115 
FHR C29 O30  doub N N 116 
FHR C31 O32  doub N N 117 
FHR N12 H1   sing N N 118 
FHR C13 H2   sing N N 119 
FHR C15 H3   sing N N 120 
FHR C17 H4   sing N N 121 
FHR C17 H5   sing N N 122 
FHR C20 H6   sing N N 123 
FHR C20 H7   sing N N 124 
FHR C24 H8   sing N N 125 
FHR C24 H9   sing N N 126 
FHR C26 H10  sing N N 127 
FHR C26 H11  sing N N 128 
FHR C04 H13  sing N N 129 
FHR C06 H14  sing N N 130 
FHR C07 H15  sing N N 131 
FHR C08 H16  sing N N 132 
FHR C09 H17  sing N N 133 
FHR C14 H18  sing N N 134 
FHR C14 H19  sing N N 135 
FHR C16 H20  sing N N 136 
FHR C16 H21  sing N N 137 
FHR C18 H22  sing N N 138 
FHR C18 H23  sing N N 139 
FHR C19 H24  sing N N 140 
FHR C19 H25  sing N N 141 
FHR C23 H26  sing N N 142 
FHR C25 H27  sing N N 143 
FHR C27 H28  sing N N 144 
FHR C27 H29  sing N N 145 
FHR C31 H31  sing N N 146 
FHR N11 H32  sing N N 147 
FHR N22 H33  sing N N 148 
FHR N28 H34  sing N N 149 
FHR C26 C27  sing N N 150 
GLN N   CA   sing N N 151 
GLN N   H    sing N N 152 
GLN N   H2   sing N N 153 
GLN CA  C    sing N N 154 
GLN CA  CB   sing N N 155 
GLN CA  HA   sing N N 156 
GLN C   O    doub N N 157 
GLN C   OXT  sing N N 158 
GLN CB  CG   sing N N 159 
GLN CB  HB2  sing N N 160 
GLN CB  HB3  sing N N 161 
GLN CG  CD   sing N N 162 
GLN CG  HG2  sing N N 163 
GLN CG  HG3  sing N N 164 
GLN CD  OE1  doub N N 165 
GLN CD  NE2  sing N N 166 
GLN NE2 HE21 sing N N 167 
GLN NE2 HE22 sing N N 168 
GLN OXT HXT  sing N N 169 
GLU N   CA   sing N N 170 
GLU N   H    sing N N 171 
GLU N   H2   sing N N 172 
GLU CA  C    sing N N 173 
GLU CA  CB   sing N N 174 
GLU CA  HA   sing N N 175 
GLU C   O    doub N N 176 
GLU C   OXT  sing N N 177 
GLU CB  CG   sing N N 178 
GLU CB  HB2  sing N N 179 
GLU CB  HB3  sing N N 180 
GLU CG  CD   sing N N 181 
GLU CG  HG2  sing N N 182 
GLU CG  HG3  sing N N 183 
GLU CD  OE1  doub N N 184 
GLU CD  OE2  sing N N 185 
GLU OE2 HE2  sing N N 186 
GLU OXT HXT  sing N N 187 
GLY N   CA   sing N N 188 
GLY N   H    sing N N 189 
GLY N   H2   sing N N 190 
GLY CA  C    sing N N 191 
GLY CA  HA2  sing N N 192 
GLY CA  HA3  sing N N 193 
GLY C   O    doub N N 194 
GLY C   OXT  sing N N 195 
GLY OXT HXT  sing N N 196 
HIS N   CA   sing N N 197 
HIS N   H    sing N N 198 
HIS N   H2   sing N N 199 
HIS CA  C    sing N N 200 
HIS CA  CB   sing N N 201 
HIS CA  HA   sing N N 202 
HIS C   O    doub N N 203 
HIS C   OXT  sing N N 204 
HIS CB  CG   sing N N 205 
HIS CB  HB2  sing N N 206 
HIS CB  HB3  sing N N 207 
HIS CG  ND1  sing Y N 208 
HIS CG  CD2  doub Y N 209 
HIS ND1 CE1  doub Y N 210 
HIS ND1 HD1  sing N N 211 
HIS CD2 NE2  sing Y N 212 
HIS CD2 HD2  sing N N 213 
HIS CE1 NE2  sing Y N 214 
HIS CE1 HE1  sing N N 215 
HIS NE2 HE2  sing N N 216 
HIS OXT HXT  sing N N 217 
HOH O   H1   sing N N 218 
HOH O   H2   sing N N 219 
ILE N   CA   sing N N 220 
ILE N   H    sing N N 221 
ILE N   H2   sing N N 222 
ILE CA  C    sing N N 223 
ILE CA  CB   sing N N 224 
ILE CA  HA   sing N N 225 
ILE C   O    doub N N 226 
ILE C   OXT  sing N N 227 
ILE CB  CG1  sing N N 228 
ILE CB  CG2  sing N N 229 
ILE CB  HB   sing N N 230 
ILE CG1 CD1  sing N N 231 
ILE CG1 HG12 sing N N 232 
ILE CG1 HG13 sing N N 233 
ILE CG2 HG21 sing N N 234 
ILE CG2 HG22 sing N N 235 
ILE CG2 HG23 sing N N 236 
ILE CD1 HD11 sing N N 237 
ILE CD1 HD12 sing N N 238 
ILE CD1 HD13 sing N N 239 
ILE OXT HXT  sing N N 240 
LEU N   CA   sing N N 241 
LEU N   H    sing N N 242 
LEU N   H2   sing N N 243 
LEU CA  C    sing N N 244 
LEU CA  CB   sing N N 245 
LEU CA  HA   sing N N 246 
LEU C   O    doub N N 247 
LEU C   OXT  sing N N 248 
LEU CB  CG   sing N N 249 
LEU CB  HB2  sing N N 250 
LEU CB  HB3  sing N N 251 
LEU CG  CD1  sing N N 252 
LEU CG  CD2  sing N N 253 
LEU CG  HG   sing N N 254 
LEU CD1 HD11 sing N N 255 
LEU CD1 HD12 sing N N 256 
LEU CD1 HD13 sing N N 257 
LEU CD2 HD21 sing N N 258 
LEU CD2 HD22 sing N N 259 
LEU CD2 HD23 sing N N 260 
LEU OXT HXT  sing N N 261 
LYS N   CA   sing N N 262 
LYS N   H    sing N N 263 
LYS N   H2   sing N N 264 
LYS CA  C    sing N N 265 
LYS CA  CB   sing N N 266 
LYS CA  HA   sing N N 267 
LYS C   O    doub N N 268 
LYS C   OXT  sing N N 269 
LYS CB  CG   sing N N 270 
LYS CB  HB2  sing N N 271 
LYS CB  HB3  sing N N 272 
LYS CG  CD   sing N N 273 
LYS CG  HG2  sing N N 274 
LYS CG  HG3  sing N N 275 
LYS CD  CE   sing N N 276 
LYS CD  HD2  sing N N 277 
LYS CD  HD3  sing N N 278 
LYS CE  NZ   sing N N 279 
LYS CE  HE2  sing N N 280 
LYS CE  HE3  sing N N 281 
LYS NZ  HZ1  sing N N 282 
LYS NZ  HZ2  sing N N 283 
LYS NZ  HZ3  sing N N 284 
LYS OXT HXT  sing N N 285 
MET N   CA   sing N N 286 
MET N   H    sing N N 287 
MET N   H2   sing N N 288 
MET CA  C    sing N N 289 
MET CA  CB   sing N N 290 
MET CA  HA   sing N N 291 
MET C   O    doub N N 292 
MET C   OXT  sing N N 293 
MET CB  CG   sing N N 294 
MET CB  HB2  sing N N 295 
MET CB  HB3  sing N N 296 
MET CG  SD   sing N N 297 
MET CG  HG2  sing N N 298 
MET CG  HG3  sing N N 299 
MET SD  CE   sing N N 300 
MET CE  HE1  sing N N 301 
MET CE  HE2  sing N N 302 
MET CE  HE3  sing N N 303 
MET OXT HXT  sing N N 304 
PHE N   CA   sing N N 305 
PHE N   H    sing N N 306 
PHE N   H2   sing N N 307 
PHE CA  C    sing N N 308 
PHE CA  CB   sing N N 309 
PHE CA  HA   sing N N 310 
PHE C   O    doub N N 311 
PHE C   OXT  sing N N 312 
PHE CB  CG   sing N N 313 
PHE CB  HB2  sing N N 314 
PHE CB  HB3  sing N N 315 
PHE CG  CD1  doub Y N 316 
PHE CG  CD2  sing Y N 317 
PHE CD1 CE1  sing Y N 318 
PHE CD1 HD1  sing N N 319 
PHE CD2 CE2  doub Y N 320 
PHE CD2 HD2  sing N N 321 
PHE CE1 CZ   doub Y N 322 
PHE CE1 HE1  sing N N 323 
PHE CE2 CZ   sing Y N 324 
PHE CE2 HE2  sing N N 325 
PHE CZ  HZ   sing N N 326 
PHE OXT HXT  sing N N 327 
PRO N   CA   sing N N 328 
PRO N   CD   sing N N 329 
PRO N   H    sing N N 330 
PRO CA  C    sing N N 331 
PRO CA  CB   sing N N 332 
PRO CA  HA   sing N N 333 
PRO C   O    doub N N 334 
PRO C   OXT  sing N N 335 
PRO CB  CG   sing N N 336 
PRO CB  HB2  sing N N 337 
PRO CB  HB3  sing N N 338 
PRO CG  CD   sing N N 339 
PRO CG  HG2  sing N N 340 
PRO CG  HG3  sing N N 341 
PRO CD  HD2  sing N N 342 
PRO CD  HD3  sing N N 343 
PRO OXT HXT  sing N N 344 
SER N   CA   sing N N 345 
SER N   H    sing N N 346 
SER N   H2   sing N N 347 
SER CA  C    sing N N 348 
SER CA  CB   sing N N 349 
SER CA  HA   sing N N 350 
SER C   O    doub N N 351 
SER C   OXT  sing N N 352 
SER CB  OG   sing N N 353 
SER CB  HB2  sing N N 354 
SER CB  HB3  sing N N 355 
SER OG  HG   sing N N 356 
SER OXT HXT  sing N N 357 
THR N   CA   sing N N 358 
THR N   H    sing N N 359 
THR N   H2   sing N N 360 
THR CA  C    sing N N 361 
THR CA  CB   sing N N 362 
THR CA  HA   sing N N 363 
THR C   O    doub N N 364 
THR C   OXT  sing N N 365 
THR CB  OG1  sing N N 366 
THR CB  CG2  sing N N 367 
THR CB  HB   sing N N 368 
THR OG1 HG1  sing N N 369 
THR CG2 HG21 sing N N 370 
THR CG2 HG22 sing N N 371 
THR CG2 HG23 sing N N 372 
THR OXT HXT  sing N N 373 
TRP N   CA   sing N N 374 
TRP N   H    sing N N 375 
TRP N   H2   sing N N 376 
TRP CA  C    sing N N 377 
TRP CA  CB   sing N N 378 
TRP CA  HA   sing N N 379 
TRP C   O    doub N N 380 
TRP C   OXT  sing N N 381 
TRP CB  CG   sing N N 382 
TRP CB  HB2  sing N N 383 
TRP CB  HB3  sing N N 384 
TRP CG  CD1  doub Y N 385 
TRP CG  CD2  sing Y N 386 
TRP CD1 NE1  sing Y N 387 
TRP CD1 HD1  sing N N 388 
TRP CD2 CE2  doub Y N 389 
TRP CD2 CE3  sing Y N 390 
TRP NE1 CE2  sing Y N 391 
TRP NE1 HE1  sing N N 392 
TRP CE2 CZ2  sing Y N 393 
TRP CE3 CZ3  doub Y N 394 
TRP CE3 HE3  sing N N 395 
TRP CZ2 CH2  doub Y N 396 
TRP CZ2 HZ2  sing N N 397 
TRP CZ3 CH2  sing Y N 398 
TRP CZ3 HZ3  sing N N 399 
TRP CH2 HH2  sing N N 400 
TRP OXT HXT  sing N N 401 
TYR N   CA   sing N N 402 
TYR N   H    sing N N 403 
TYR N   H2   sing N N 404 
TYR CA  C    sing N N 405 
TYR CA  CB   sing N N 406 
TYR CA  HA   sing N N 407 
TYR C   O    doub N N 408 
TYR C   OXT  sing N N 409 
TYR CB  CG   sing N N 410 
TYR CB  HB2  sing N N 411 
TYR CB  HB3  sing N N 412 
TYR CG  CD1  doub Y N 413 
TYR CG  CD2  sing Y N 414 
TYR CD1 CE1  sing Y N 415 
TYR CD1 HD1  sing N N 416 
TYR CD2 CE2  doub Y N 417 
TYR CD2 HD2  sing N N 418 
TYR CE1 CZ   doub Y N 419 
TYR CE1 HE1  sing N N 420 
TYR CE2 CZ   sing Y N 421 
TYR CE2 HE2  sing N N 422 
TYR CZ  OH   sing N N 423 
TYR OH  HH   sing N N 424 
TYR OXT HXT  sing N N 425 
VAL N   CA   sing N N 426 
VAL N   H    sing N N 427 
VAL N   H2   sing N N 428 
VAL CA  C    sing N N 429 
VAL CA  CB   sing N N 430 
VAL CA  HA   sing N N 431 
VAL C   O    doub N N 432 
VAL C   OXT  sing N N 433 
VAL CB  CG1  sing N N 434 
VAL CB  CG2  sing N N 435 
VAL CB  HB   sing N N 436 
VAL CG1 HG11 sing N N 437 
VAL CG1 HG12 sing N N 438 
VAL CG1 HG13 sing N N 439 
VAL CG2 HG21 sing N N 440 
VAL CG2 HG22 sing N N 441 
VAL CG2 HG23 sing N N 442 
VAL OXT HXT  sing N N 443 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7CA8 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YWZ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014743 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009728 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009711 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 25.62398 1.50364  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 19.97189 1.75589  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 15.80542 1.70748  0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 1.23737  29.19336 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 1   ? 11.07160  6.86870   -16.59385 1.000 60.96527 ? 3   PHE A N   1 
ATOM   2    C CA  . PHE A 1 1   ? 10.23341  7.69657   -17.44577 1.000 60.05439 ? 3   PHE A CA  1 
ATOM   3    C C   . PHE A 1 1   ? 8.90229   6.99156   -17.69071 1.000 56.45418 ? 3   PHE A C   1 
ATOM   4    O O   . PHE A 1 1   ? 8.60363   6.60635   -18.81936 1.000 55.13054 ? 3   PHE A O   1 
ATOM   5    C CB  . PHE A 1 1   ? 10.95791  7.98573   -18.76126 1.000 55.98654 ? 3   PHE A CB  1 
ATOM   6    C CG  . PHE A 1 1   ? 10.41405  9.16860   -19.51596 1.000 54.63764 ? 3   PHE A CG  1 
ATOM   7    C CD1 . PHE A 1 1   ? 9.44526   9.00019   -20.49159 1.000 52.68881 ? 3   PHE A CD1 1 
ATOM   8    C CD2 . PHE A 1 1   ? 10.88586  10.44478  -19.26219 1.000 55.24696 ? 3   PHE A CD2 1 
ATOM   9    C CE1 . PHE A 1 1   ? 8.94887   10.08220  -21.19543 1.000 50.95756 ? 3   PHE A CE1 1 
ATOM   10   C CE2 . PHE A 1 1   ? 10.39483  11.53157  -19.96303 1.000 55.39419 ? 3   PHE A CE2 1 
ATOM   11   C CZ  . PHE A 1 1   ? 9.42173   11.34913  -20.92957 1.000 55.53702 ? 3   PHE A CZ  1 
ATOM   12   N N   . ARG A 1 2   ? 8.11101   6.81626   -16.62732 1.000 54.71110 ? 4   ARG A N   1 
ATOM   13   C CA  . ARG A 1 2   ? 6.90880   5.99546   -16.70297 1.000 51.26930 ? 4   ARG A CA  1 
ATOM   14   C C   . ARG A 1 2   ? 5.78288   6.73820   -17.40916 1.000 41.69822 ? 4   ARG A C   1 
ATOM   15   O O   . ARG A 1 2   ? 5.54602   7.93052   -17.17297 1.000 38.30339 ? 4   ARG A O   1 
ATOM   16   C CB  . ARG A 1 2   ? 6.43709   5.55894   -15.30451 1.000 49.84451 ? 4   ARG A CB  1 
ATOM   17   C CG  . ARG A 1 2   ? 7.02700   4.22741   -14.80606 1.000 47.96346 ? 4   ARG A CG  1 
ATOM   18   C CD  . ARG A 1 2   ? 5.95254   3.15124   -14.52065 1.000 49.97101 ? 4   ARG A CD  1 
ATOM   19   N NE  . ARG A 1 2   ? 6.49951   2.04791   -13.71653 1.000 53.71475 ? 4   ARG A NE  1 
ATOM   20   C CZ  . ARG A 1 2   ? 6.13511   0.76634   -13.81228 1.000 47.87770 ? 4   ARG A CZ  1 
ATOM   21   N NH1 . ARG A 1 2   ? 5.20927   0.38368   -14.68688 1.000 39.91530 ? 4   ARG A NH1 1 
ATOM   22   N NH2 . ARG A 1 2   ? 6.71645   -0.14316  -13.03658 1.000 47.02361 ? 4   ARG A NH2 1 
ATOM   23   N N   . LYS A 1 3   ? 5.10150   6.02595   -18.29491 1.000 38.11518 ? 5   LYS A N   1 
ATOM   24   C CA  . LYS A 1 3   ? 3.81676   6.49638   -18.77088 1.000 39.24589 ? 5   LYS A CA  1 
ATOM   25   C C   . LYS A 1 3   ? 2.86992   6.57175   -17.58353 1.000 31.82116 ? 5   LYS A C   1 
ATOM   26   O O   . LYS A 1 3   ? 2.79379   5.63918   -16.78339 1.000 37.45141 ? 5   LYS A O   1 
ATOM   27   C CB  . LYS A 1 3   ? 3.27194   5.56136   -19.84703 1.000 36.93546 ? 5   LYS A CB  1 
ATOM   28   C CG  . LYS A 1 3   ? 2.52632   6.29214   -20.94339 1.000 38.75539 ? 5   LYS A CG  1 
ATOM   29   C CD  . LYS A 1 3   ? 1.76379   5.33556   -21.84284 1.000 43.68194 ? 5   LYS A CD  1 
ATOM   30   C CE  . LYS A 1 3   ? 2.70067   4.48900   -22.70832 1.000 37.91926 ? 5   LYS A CE  1 
ATOM   31   N NZ  . LYS A 1 3   ? 1.87043   3.61495   -23.60773 1.000 50.22310 ? 5   LYS A NZ  1 
ATOM   32   N N   . MET A 1 4   ? 2.19833   7.70248   -17.43431 1.000 30.71882 ? 6   MET A N   1 
ATOM   33   C CA  . MET A 1 4   ? 1.23336   7.87709   -16.36363 1.000 29.42244 ? 6   MET A CA  1 
ATOM   34   C C   . MET A 1 4   ? -0.08441  8.36347   -16.93249 1.000 26.38362 ? 6   MET A C   1 
ATOM   35   O O   . MET A 1 4   ? -0.11594  9.12076   -17.90505 1.000 23.48111 ? 6   MET A O   1 
ATOM   36   C CB  . MET A 1 4   ? 1.71175   8.87418   -15.32650 1.000 28.34594 ? 6   MET A CB  1 
ATOM   37   C CG  . MET A 1 4   ? 3.08951   8.53616   -14.74280 1.000 33.69818 ? 6   MET A CG  1 
ATOM   38   S SD  . MET A 1 4   ? 3.31588   9.44140   -13.20861 1.000 38.87725 ? 6   MET A SD  1 
ATOM   39   C CE  . MET A 1 4   ? 3.04218   11.11573  -13.77322 1.000 41.10177 ? 6   MET A CE  1 
ATOM   40   N N   . ALA A 1 5   ? -1.16720  7.92109   -16.29771 1.000 27.64414 ? 7   ALA A N   1 
ATOM   41   C CA  . ALA A 1 5   ? -2.47698  8.49858   -16.52124 1.000 26.26039 ? 7   ALA A CA  1 
ATOM   42   C C   . ALA A 1 5   ? -2.64669  9.74814   -15.65911 1.000 27.99125 ? 7   ALA A C   1 
ATOM   43   O O   . ALA A 1 5   ? -1.97741  9.92760   -14.63816 1.000 26.36738 ? 7   ALA A O   1 
ATOM   44   C CB  . ALA A 1 5   ? -3.58372  7.48301   -16.19536 1.000 22.71238 ? 7   ALA A CB  1 
ATOM   45   N N   . PHE A 1 6   ? -3.54656  10.62684  -16.08664 1.000 22.42926 ? 8   PHE A N   1 
ATOM   46   C CA  . PHE A 1 6   ? -3.89011  11.75422  -15.24466 1.000 25.52282 ? 8   PHE A CA  1 
ATOM   47   C C   . PHE A 1 6   ? -4.60917  11.26156  -13.99465 1.000 25.47901 ? 8   PHE A C   1 
ATOM   48   O O   . PHE A 1 6   ? -5.33315  10.26471  -14.03938 1.000 25.73174 ? 8   PHE A O   1 
ATOM   49   C CB  . PHE A 1 6   ? -4.77314  12.75614  -15.99524 1.000 26.80534 ? 8   PHE A CB  1 
ATOM   50   C CG  . PHE A 1 6   ? -4.03666  13.50903  -17.07105 1.000 26.16497 ? 8   PHE A CG  1 
ATOM   51   C CD1 . PHE A 1 6   ? -3.25880  14.61315  -16.75019 1.000 29.44883 ? 8   PHE A CD1 1 
ATOM   52   C CD2 . PHE A 1 6   ? -4.10981  13.10288  -18.38723 1.000 28.38763 ? 8   PHE A CD2 1 
ATOM   53   C CE1 . PHE A 1 6   ? -2.56131  15.29909  -17.73384 1.000 30.48644 ? 8   PHE A CE1 1 
ATOM   54   C CE2 . PHE A 1 6   ? -3.41096  13.78917  -19.37970 1.000 30.84169 ? 8   PHE A CE2 1 
ATOM   55   C CZ  . PHE A 1 6   ? -2.64954  14.89057  -19.04540 1.000 32.92460 ? 8   PHE A CZ  1 
ATOM   56   N N   . PRO A 1 7   ? -4.42482  11.94144  -12.86598 1.000 23.94410 ? 9   PRO A N   1 
ATOM   57   C CA  . PRO A 1 7   ? -5.26266  11.64845  -11.69609 1.000 23.84599 ? 9   PRO A CA  1 
ATOM   58   C C   . PRO A 1 7   ? -6.73809  11.76208  -12.07563 1.000 23.54712 ? 9   PRO A C   1 
ATOM   59   O O   . PRO A 1 7   ? -7.16984  12.75759  -12.65399 1.000 26.13648 ? 9   PRO A O   1 
ATOM   60   C CB  . PRO A 1 7   ? -4.84424  12.71562  -10.67524 1.000 24.87294 ? 9   PRO A CB  1 
ATOM   61   C CG  . PRO A 1 7   ? -3.49963  13.24192  -11.17893 1.000 26.52314 ? 9   PRO A CG  1 
ATOM   62   C CD  . PRO A 1 7   ? -3.58837  13.13721  -12.67600 1.000 25.88383 ? 9   PRO A CD  1 
ATOM   63   N N   . SER A 1 8   ? -7.49872  10.72135  -11.76808 1.000 21.84913 ? 10  SER A N   1 
ATOM   64   C CA  . SER A 1 8   ? -8.83309  10.55234  -12.33755 1.000 24.57353 ? 10  SER A CA  1 
ATOM   65   C C   . SER A 1 8   ? -9.95556  11.09316  -11.45944 1.000 25.15543 ? 10  SER A C   1 
ATOM   66   O O   . SER A 1 8   ? -11.12523 11.02567  -11.86919 1.000 23.72285 ? 10  SER A O   1 
ATOM   67   C CB  . SER A 1 8   ? -9.08114  9.07047   -12.63124 1.000 23.13136 ? 10  SER A CB  1 
ATOM   68   O OG  . SER A 1 8   ? -9.00113  8.28907   -11.45185 1.000 25.67014 ? 10  SER A OG  1 
ATOM   69   N N   . GLY A 1 9   ? -9.64865  11.62188  -10.27241 1.000 21.08393 ? 11  GLY A N   1 
ATOM   70   C CA  . GLY A 1 9   ? -10.72159 11.97030  -9.34147  1.000 25.15003 ? 11  GLY A CA  1 
ATOM   71   C C   . GLY A 1 9   ? -11.73384 12.94579  -9.92085  1.000 27.51972 ? 11  GLY A C   1 
ATOM   72   O O   . GLY A 1 9   ? -12.94340 12.82048  -9.68587  1.000 23.99710 ? 11  GLY A O   1 
ATOM   73   N N   . LYS A 1 10  ? -11.26034 13.92621  -10.69672 1.000 26.02830 ? 12  LYS A N   1 
ATOM   74   C CA  . LYS A 1 10  ? -12.18526 14.91112  -11.25138 1.000 27.62238 ? 12  LYS A CA  1 
ATOM   75   C C   . LYS A 1 10  ? -13.19065 14.27394  -12.21104 1.000 27.23681 ? 12  LYS A C   1 
ATOM   76   O O   . LYS A 1 10  ? -14.30669 14.78581  -12.36324 1.000 28.19121 ? 12  LYS A O   1 
ATOM   77   C CB  . LYS A 1 10  ? -11.41313 16.01886  -11.95596 1.000 25.35293 ? 12  LYS A CB  1 
ATOM   78   C CG  . LYS A 1 10  ? -10.70320 16.99904  -11.01024 1.000 29.42206 ? 12  LYS A CG  1 
ATOM   79   C CD  . LYS A 1 10  ? -10.07371 18.13247  -11.80507 1.000 29.76180 ? 12  LYS A CD  1 
ATOM   80   C CE  . LYS A 1 10  ? -9.56952  19.25508  -10.89087 1.000 39.05796 ? 12  LYS A CE  1 
ATOM   81   N NZ  . LYS A 1 10  ? -8.43736  18.78686  -10.04816 1.000 38.61686 ? 12  LYS A NZ  1 
ATOM   82   N N   . VAL A 1 11  ? -12.82774 13.16419  -12.85285 1.000 24.99186 ? 13  VAL A N   1 
ATOM   83   C CA  . VAL A 1 11  ? -13.75157 12.48362  -13.76567 1.000 24.69593 ? 13  VAL A CA  1 
ATOM   84   C C   . VAL A 1 11  ? -14.61266 11.47332  -13.02708 1.000 27.04112 ? 13  VAL A C   1 
ATOM   85   O O   . VAL A 1 11  ? -15.78621 11.29536  -13.36420 1.000 24.05445 ? 13  VAL A O   1 
ATOM   86   C CB  . VAL A 1 11  ? -12.97999 11.81525  -14.92802 1.000 21.39932 ? 13  VAL A CB  1 
ATOM   87   C CG1 . VAL A 1 11  ? -13.96593 11.11692  -15.88752 1.000 24.92909 ? 13  VAL A CG1 1 
ATOM   88   C CG2 . VAL A 1 11  ? -12.16516 12.83854  -15.67287 1.000 21.11166 ? 13  VAL A CG2 1 
ATOM   89   N N   . GLU A 1 12  ? -14.05124 10.80695  -12.01119 1.000 24.10737 ? 14  GLU A N   1 
ATOM   90   C CA  . GLU A 1 12  ? -14.82737 9.84608   -11.22174 1.000 25.73100 ? 14  GLU A CA  1 
ATOM   91   C C   . GLU A 1 12  ? -16.10986 10.45514  -10.67274 1.000 23.71429 ? 14  GLU A C   1 
ATOM   92   O O   . GLU A 1 12  ? -17.14589 9.78755   -10.61852 1.000 23.04293 ? 14  GLU A O   1 
ATOM   93   C CB  . GLU A 1 12  ? -13.98859 9.31669   -10.05237 1.000 24.87853 ? 14  GLU A CB  1 
ATOM   94   C CG  . GLU A 1 12  ? -12.79812 8.43785   -10.45989 1.000 23.55829 ? 14  GLU A CG  1 
ATOM   95   C CD  . GLU A 1 12  ? -11.81738 8.24094   -9.29645  1.000 28.09068 ? 14  GLU A CD  1 
ATOM   96   O OE1 . GLU A 1 12  ? -10.59933 8.49110   -9.47202  1.000 26.59389 ? 14  GLU A OE1 1 
ATOM   97   O OE2 . GLU A 1 12  ? -12.26743 7.82911   -8.20571  1.000 25.26381 ? 14  GLU A OE2 1 
ATOM   98   N N   . GLY A 1 13  ? -16.04483 11.69207  -10.20100 1.000 25.07222 ? 15  GLY A N   1 
ATOM   99   C CA  . GLY A 1 13  ? -17.22285 12.36121  -9.65686  1.000 25.13953 ? 15  GLY A CA  1 
ATOM   100  C C   . GLY A 1 13  ? -18.27786 12.72969  -10.68075 1.000 26.17643 ? 15  GLY A C   1 
ATOM   101  O O   . GLY A 1 13  ? -19.33744 13.25042  -10.30974 1.000 26.78302 ? 15  GLY A O   1 
ATOM   102  N N   . CYS A 1 14  ? -18.01426 12.47326  -11.95810 1.000 24.57988 ? 16  CYS A N   1 
ATOM   103  C CA  . CYS A 1 14  ? -18.95743 12.73609  -13.03766 1.000 26.38340 ? 16  CYS A CA  1 
ATOM   104  C C   . CYS A 1 14  ? -19.57776 11.48219  -13.62321 1.000 25.56302 ? 16  CYS A C   1 
ATOM   105  O O   . CYS A 1 14  ? -20.45969 11.60005  -14.47441 1.000 25.10936 ? 16  CYS A O   1 
ATOM   106  C CB  . CYS A 1 14  ? -18.26615 13.50621  -14.17536 1.000 26.66317 ? 16  CYS A CB  1 
ATOM   107  S SG  . CYS A 1 14  ? -17.56594 15.04977  -13.66103 1.000 30.08438 ? 16  CYS A SG  1 
ATOM   108  N N   . MET A 1 15  ? -19.14222 10.29489  -13.21013 1.000 24.43880 ? 17  MET A N   1 
ATOM   109  C CA  . MET A 1 15  ? -19.60785 9.06389   -13.83110 1.000 27.37947 ? 17  MET A CA  1 
ATOM   110  C C   . MET A 1 15  ? -20.90894 8.61875   -13.19748 1.000 27.21728 ? 17  MET A C   1 
ATOM   111  O O   . MET A 1 15  ? -21.02233 8.55745   -11.97080 1.000 23.96035 ? 17  MET A O   1 
ATOM   112  C CB  . MET A 1 15  ? -18.57972 7.94467   -13.70317 1.000 25.99190 ? 17  MET A CB  1 
ATOM   113  C CG  . MET A 1 15  ? -17.23831 8.24728   -14.35826 1.000 21.78249 ? 17  MET A CG  1 
ATOM   114  S SD  . MET A 1 15  ? -17.35802 8.82588   -16.06019 1.000 25.45263 ? 17  MET A SD  1 
ATOM   115  C CE  . MET A 1 15  ? -18.27946 7.48118   -16.84177 1.000 28.20962 ? 17  MET A CE  1 
ATOM   116  N N   . VAL A 1 16  ? -21.87284 8.26827   -14.04266 1.000 27.35331 ? 18  VAL A N   1 
ATOM   117  C CA  . VAL A 1 16  ? -23.16811 7.77593   -13.60173 1.000 25.41195 ? 18  VAL A CA  1 
ATOM   118  C C   . VAL A 1 16  ? -23.51729 6.52941   -14.40680 1.000 29.11603 ? 18  VAL A C   1 
ATOM   119  O O   . VAL A 1 16  ? -22.82906 6.15318   -15.35844 1.000 23.68647 ? 18  VAL A O   1 
ATOM   120  C CB  . VAL A 1 16  ? -24.26962 8.85038   -13.73888 1.000 27.60256 ? 18  VAL A CB  1 
ATOM   121  C CG1 . VAL A 1 16  ? -23.92523 10.06467  -12.87548 1.000 25.99534 ? 18  VAL A CG1 1 
ATOM   122  C CG2 . VAL A 1 16  ? -24.44419 9.25681   -15.20386 1.000 23.56583 ? 18  VAL A CG2 1 
ATOM   123  N N   . GLN A 1 17  ? -24.60352 5.88499   -13.99764 1.000 29.26802 ? 19  GLN A N   1 
ATOM   124  C CA  . GLN A 1 17  ? -25.15651 4.71878   -14.67352 1.000 32.09004 ? 19  GLN A CA  1 
ATOM   125  C C   . GLN A 1 17  ? -26.42823 5.13856   -15.40401 1.000 31.18580 ? 19  GLN A C   1 
ATOM   126  O O   . GLN A 1 17  ? -27.26788 5.83481   -14.82580 1.000 28.08451 ? 19  GLN A O   1 
ATOM   127  C CB  . GLN A 1 17  ? -25.44435 3.61239   -13.65315 1.000 32.33019 ? 19  GLN A CB  1 
ATOM   128  C CG  . GLN A 1 17  ? -26.03734 2.34919   -14.24016 1.000 37.62401 ? 19  GLN A CG  1 
ATOM   129  C CD  . GLN A 1 17  ? -26.23638 1.26148   -13.19802 1.000 44.78698 ? 19  GLN A CD  1 
ATOM   130  O OE1 . GLN A 1 17  ? -26.40330 0.08969   -13.53709 1.000 55.18215 ? 19  GLN A OE1 1 
ATOM   131  N NE2 . GLN A 1 17  ? -26.21162 1.64163   -11.92856 1.000 42.86880 ? 19  GLN A NE2 1 
ATOM   132  N N   . VAL A 1 18  ? -26.54555 4.77424   -16.68513 1.000 27.94094 ? 20  VAL A N   1 
ATOM   133  C CA  . VAL A 1 18  ? -27.71875 5.10736   -17.49677 1.000 30.70980 ? 20  VAL A CA  1 
ATOM   134  C C   . VAL A 1 18  ? -28.35124 3.81356   -17.96490 1.000 32.74713 ? 20  VAL A C   1 
ATOM   135  O O   . VAL A 1 18  ? -27.67945 2.97621   -18.58037 1.000 29.29953 ? 20  VAL A O   1 
ATOM   136  C CB  . VAL A 1 18  ? -27.38515 6.00021   -18.71056 1.000 27.51755 ? 20  VAL A CB  1 
ATOM   137  C CG1 . VAL A 1 18  ? -28.67275 6.29332   -19.54855 1.000 25.20696 ? 20  VAL A CG1 1 
ATOM   138  C CG2 . VAL A 1 18  ? -26.72262 7.29217   -18.27127 1.000 25.46071 ? 20  VAL A CG2 1 
ATOM   139  N N   . THR A 1 19  ? -29.65257 3.66640   -17.70867 1.000 31.14383 ? 21  THR A N   1 
ATOM   140  C CA  . THR A 1 19  ? -30.38055 2.46439   -18.08712 1.000 30.52808 ? 21  THR A CA  1 
ATOM   141  C C   . THR A 1 19  ? -31.60235 2.85312   -18.91008 1.000 30.80631 ? 21  THR A C   1 
ATOM   142  O O   . THR A 1 19  ? -32.31957 3.79767   -18.56369 1.000 32.15233 ? 21  THR A O   1 
ATOM   143  C CB  . THR A 1 19  ? -30.79122 1.65993   -16.85032 1.000 33.13729 ? 21  THR A CB  1 
ATOM   144  O OG1 . THR A 1 19  ? -29.61550 1.23396   -16.15045 1.000 35.35546 ? 21  THR A OG1 1 
ATOM   145  C CG2 . THR A 1 19  ? -31.59527 0.42367   -17.25414 1.000 36.87736 ? 21  THR A CG2 1 
ATOM   146  N N   . CYS A 1 20  ? -31.80757 2.15051   -20.02086 1.000 29.28400 ? 22  CYS A N   1 
ATOM   147  C CA  . CYS A 1 20  ? -32.97794 2.32387   -20.86911 1.000 31.54417 ? 22  CYS A CA  1 
ATOM   148  C C   . CYS A 1 20  ? -33.44566 0.92078   -21.21219 1.000 35.49954 ? 22  CYS A C   1 
ATOM   149  O O   . CYS A 1 20  ? -32.72168 0.16433   -21.87003 1.000 33.66921 ? 22  CYS A O   1 
ATOM   150  C CB  . CYS A 1 20  ? -32.65848 3.13429   -22.12473 1.000 32.94199 ? 22  CYS A CB  1 
ATOM   151  S SG  . CYS A 1 20  ? -34.10600 3.55385   -23.14218 1.000 38.78213 ? 22  CYS A SG  1 
ATOM   152  N N   . GLY A 1 21  ? -34.62115 0.56390   -20.72383 1.000 36.66563 ? 23  GLY A N   1 
ATOM   153  C CA  . GLY A 1 21  ? -35.10702 -0.79222  -20.89339 1.000 37.79703 ? 23  GLY A CA  1 
ATOM   154  C C   . GLY A 1 21  ? -34.17752 -1.77574  -20.21715 1.000 31.16837 ? 23  GLY A C   1 
ATOM   155  O O   . GLY A 1 21  ? -33.91307 -1.70592  -19.00981 1.000 37.37047 ? 23  GLY A O   1 
ATOM   156  N N   . THR A 1 22  ? -33.67185 -2.70976  -21.01151 1.000 31.55352 ? 24  THR A N   1 
ATOM   157  C CA  . THR A 1 22  ? -32.76257 -3.75040  -20.56114 1.000 35.57438 ? 24  THR A CA  1 
ATOM   158  C C   . THR A 1 22  ? -31.29482 -3.34938  -20.68656 1.000 35.13385 ? 24  THR A C   1 
ATOM   159  O O   . THR A 1 22  ? -30.42659 -4.10102  -20.23443 1.000 35.53540 ? 24  THR A O   1 
ATOM   160  C CB  . THR A 1 22  ? -33.01574 -5.02450  -21.38026 1.000 36.31159 ? 24  THR A CB  1 
ATOM   161  O OG1 . THR A 1 22  ? -32.01533 -6.00477  -21.08566 1.000 50.40418 ? 24  THR A OG1 1 
ATOM   162  C CG2 . THR A 1 22  ? -32.98344 -4.69763  -22.87879 1.000 44.09264 ? 24  THR A CG2 1 
ATOM   163  N N   . THR A 1 23  ? -31.00553 -2.19171  -21.28007 1.000 34.27170 ? 25  THR A N   1 
ATOM   164  C CA  . THR A 1 23  ? -29.64293 -1.79789  -21.64153 1.000 36.40881 ? 25  THR A CA  1 
ATOM   165  C C   . THR A 1 23  ? -29.06775 -0.84262  -20.59900 1.000 34.28860 ? 25  THR A C   1 
ATOM   166  O O   . THR A 1 23  ? -29.67029 0.19416   -20.29960 1.000 29.98052 ? 25  THR A O   1 
ATOM   167  C CB  . THR A 1 23  ? -29.62568 -1.13288  -23.02332 1.000 38.87227 ? 25  THR A CB  1 
ATOM   168  O OG1 . THR A 1 23  ? -30.18061 -2.01951  -24.00231 1.000 42.59232 ? 25  THR A OG1 1 
ATOM   169  C CG2 . THR A 1 23  ? -28.20010 -0.74491  -23.44132 1.000 36.50512 ? 25  THR A CG2 1 
ATOM   170  N N   . THR A 1 24  ? -27.88884 -1.17071  -20.07159 1.000 35.80340 ? 26  THR A N   1 
ATOM   171  C CA  . THR A 1 24  ? -27.22842 -0.32281  -19.08617 1.000 34.86972 ? 26  THR A CA  1 
ATOM   172  C C   . THR A 1 24  ? -25.79220 -0.04545  -19.52117 1.000 34.06814 ? 26  THR A C   1 
ATOM   173  O O   . THR A 1 24  ? -25.10642 -0.94328  -20.01871 1.000 35.64530 ? 26  THR A O   1 
ATOM   174  C CB  . THR A 1 24  ? -27.24814 -0.96755  -17.69678 1.000 32.21743 ? 26  THR A CB  1 
ATOM   175  O OG1 . THR A 1 24  ? -28.57927 -0.92145  -17.16654 1.000 49.99179 ? 26  THR A OG1 1 
ATOM   176  C CG2 . THR A 1 24  ? -26.34563 -0.23423  -16.74842 1.000 40.32010 ? 26  THR A CG2 1 
ATOM   177  N N   . LEU A 1 25  ? -25.35284 1.20034   -19.34981 1.000 29.02289 ? 27  LEU A N   1 
ATOM   178  C CA  . LEU A 1 25  ? -23.97225 1.58864   -19.64703 1.000 31.02277 ? 27  LEU A CA  1 
ATOM   179  C C   . LEU A 1 25  ? -23.62313 2.82957   -18.82425 1.000 30.04481 ? 27  LEU A C   1 
ATOM   180  O O   . LEU A 1 25  ? -24.35023 3.20922   -17.89510 1.000 29.06589 ? 27  LEU A O   1 
ATOM   181  C CB  . LEU A 1 25  ? -23.78513 1.81100   -21.15070 1.000 29.19248 ? 27  LEU A CB  1 
ATOM   182  C CG  . LEU A 1 25  ? -24.88186 2.53660   -21.94816 1.000 26.37751 ? 27  LEU A CG  1 
ATOM   183  C CD1 . LEU A 1 25  ? -25.04661 4.00954   -21.53214 1.000 25.85378 ? 27  LEU A CD1 1 
ATOM   184  C CD2 . LEU A 1 25  ? -24.56544 2.45099   -23.44103 1.000 26.14320 ? 27  LEU A CD2 1 
ATOM   185  N N   . ASN A 1 26  ? -22.50051 3.46490   -19.16712 1.000 26.05857 ? 28  ASN A N   1 
ATOM   186  C CA  . ASN A 1 26  ? -21.96805 4.59316   -18.41543 1.000 24.89993 ? 28  ASN A CA  1 
ATOM   187  C C   . ASN A 1 26  ? -22.38532 5.91703   -19.05344 1.000 26.61707 ? 28  ASN A C   1 
ATOM   188  O O   . ASN A 1 26  ? -22.48911 6.03827   -20.28031 1.000 25.28587 ? 28  ASN A O   1 
ATOM   189  C CB  . ASN A 1 26  ? -20.42995 4.51421   -18.32819 1.000 25.53411 ? 28  ASN A CB  1 
ATOM   190  C CG  . ASN A 1 26  ? -19.94153 3.18780   -17.72325 1.000 30.32448 ? 28  ASN A CG  1 
ATOM   191  O OD1 . ASN A 1 26  ? -20.00983 2.98423   -16.50741 1.000 29.71392 ? 28  ASN A OD1 1 
ATOM   192  N ND2 . ASN A 1 26  ? -19.47028 2.27854   -18.57315 1.000 26.00080 ? 28  ASN A ND2 1 
ATOM   193  N N   . GLY A 1 27  ? -22.61702 6.91620   -18.20193 1.000 22.53551 ? 29  GLY A N   1 
ATOM   194  C CA  . GLY A 1 27  ? -22.82239 8.27233   -18.65861 1.000 21.92723 ? 29  GLY A CA  1 
ATOM   195  C C   . GLY A 1 27  ? -21.92470 9.24651   -17.92858 1.000 22.28061 ? 29  GLY A C   1 
ATOM   196  O O   . GLY A 1 27  ? -21.35331 8.95272   -16.87302 1.000 24.54553 ? 29  GLY A O   1 
ATOM   197  N N   . LEU A 1 28  ? -21.80734 10.43145  -18.51250 1.000 24.17901 ? 30  LEU A N   1 
ATOM   198  C CA  . LEU A 1 28  ? -20.97195 11.51254  -18.00296 1.000 26.06794 ? 30  LEU A CA  1 
ATOM   199  C C   . LEU A 1 28  ? -21.88094 12.66807  -17.59132 1.000 25.60589 ? 30  LEU A C   1 
ATOM   200  O O   . LEU A 1 28  ? -22.57052 13.25718  -18.43402 1.000 23.56580 ? 30  LEU A O   1 
ATOM   201  C CB  . LEU A 1 28  ? -19.95886 11.95454  -19.06192 1.000 22.50137 ? 30  LEU A CB  1 
ATOM   202  C CG  . LEU A 1 28  ? -18.94059 13.02533  -18.68501 1.000 21.14338 ? 30  LEU A CG  1 
ATOM   203  C CD1 . LEU A 1 28  ? -17.87412 12.47095  -17.72650 1.000 25.06482 ? 30  LEU A CD1 1 
ATOM   204  C CD2 . LEU A 1 28  ? -18.26795 13.53532  -19.95761 1.000 25.96017 ? 30  LEU A CD2 1 
ATOM   205  N N   . TRP A 1 29  ? -21.88164 12.97632  -16.29885 1.000 24.73174 ? 31  TRP A N   1 
ATOM   206  C CA  . TRP A 1 29  ? -22.76085 13.98001  -15.70746 1.000 25.81190 ? 31  TRP A CA  1 
ATOM   207  C C   . TRP A 1 29  ? -21.96546 15.26284  -15.48798 1.000 24.63782 ? 31  TRP A C   1 
ATOM   208  O O   . TRP A 1 29  ? -21.14206 15.34540  -14.57064 1.000 26.63993 ? 31  TRP A O   1 
ATOM   209  C CB  . TRP A 1 29  ? -23.34076 13.45145  -14.40147 1.000 24.74664 ? 31  TRP A CB  1 
ATOM   210  C CG  . TRP A 1 29  ? -24.30701 14.35847  -13.69288 1.000 27.07890 ? 31  TRP A CG  1 
ATOM   211  C CD1 . TRP A 1 29  ? -25.05493 15.37715  -14.22985 1.000 26.93549 ? 31  TRP A CD1 1 
ATOM   212  C CD2 . TRP A 1 29  ? -24.63277 14.31001  -12.29892 1.000 29.20026 ? 31  TRP A CD2 1 
ATOM   213  N NE1 . TRP A 1 29  ? -25.82730 15.96553  -13.23942 1.000 28.16053 ? 31  TRP A NE1 1 
ATOM   214  C CE2 . TRP A 1 29  ? -25.59041 15.32345  -12.05111 1.000 29.58053 ? 31  TRP A CE2 1 
ATOM   215  C CE3 . TRP A 1 29  ? -24.21467 13.50435  -11.23978 1.000 28.73976 ? 31  TRP A CE3 1 
ATOM   216  C CZ2 . TRP A 1 29  ? -26.12930 15.54749  -10.78103 1.000 29.46981 ? 31  TRP A CZ2 1 
ATOM   217  C CZ3 . TRP A 1 29  ? -24.75315 13.72900  -9.97674  1.000 33.59656 ? 31  TRP A CZ3 1 
ATOM   218  C CH2 . TRP A 1 29  ? -25.69998 14.74018  -9.76198  1.000 31.02151 ? 31  TRP A CH2 1 
ATOM   219  N N   . LEU A 1 30  ? -22.21951 16.25894  -16.32693 1.000 24.92974 ? 32  LEU A N   1 
ATOM   220  C CA  . LEU A 1 30  ? -21.54407 17.54896  -16.27668 1.000 26.48911 ? 32  LEU A CA  1 
ATOM   221  C C   . LEU A 1 30  ? -22.62667 18.61280  -16.22894 1.000 29.62921 ? 32  LEU A C   1 
ATOM   222  O O   . LEU A 1 30  ? -23.46503 18.66921  -17.12990 1.000 29.11764 ? 32  LEU A O   1 
ATOM   223  C CB  . LEU A 1 30  ? -20.64985 17.75781  -17.49992 1.000 25.48931 ? 32  LEU A CB  1 
ATOM   224  C CG  . LEU A 1 30  ? -19.49970 16.77531  -17.70141 1.000 25.46562 ? 32  LEU A CG  1 
ATOM   225  C CD1 . LEU A 1 30  ? -18.89639 17.01478  -19.06914 1.000 25.34288 ? 32  LEU A CD1 1 
ATOM   226  C CD2 . LEU A 1 30  ? -18.44417 16.94588  -16.59437 1.000 23.79358 ? 32  LEU A CD2 1 
ATOM   227  N N   . ASP A 1 31  ? -22.61287 19.44503  -15.18677 1.000 30.48112 ? 33  ASP A N   1 
ATOM   228  C CA  . ASP A 1 31  ? -23.67237 20.44957  -14.97592 1.000 31.47929 ? 33  ASP A CA  1 
ATOM   229  C C   . ASP A 1 31  ? -24.98805 19.67619  -14.91748 1.000 29.52900 ? 33  ASP A C   1 
ATOM   230  O O   . ASP A 1 31  ? -25.07346 18.69477  -14.15890 1.000 32.18361 ? 33  ASP A O   1 
ATOM   231  C CB  . ASP A 1 31  ? -23.58515 21.53561  -16.05128 1.000 30.16600 ? 33  ASP A CB  1 
ATOM   232  C CG  . ASP A 1 31  ? -22.34365 22.38923  -15.91205 1.000 36.68126 ? 33  ASP A CG  1 
ATOM   233  O OD1 . ASP A 1 31  ? -21.95674 22.66833  -14.76132 1.000 35.18097 ? 33  ASP A OD1 1 
ATOM   234  O OD2 . ASP A 1 31  ? -21.76827 22.79507  -16.94570 1.000 37.20585 ? 33  ASP A OD2 1 
ATOM   235  N N   . ASP A 1 32  ? -26.01441 20.04923  -15.69337 1.000 31.91692 ? 34  ASP A N   1 
ATOM   236  C CA  . ASP A 1 32  ? -27.30197 19.36087  -15.66246 1.000 31.38002 ? 34  ASP A CA  1 
ATOM   237  C C   . ASP A 1 32  ? -27.53798 18.50787  -16.91228 1.000 31.87677 ? 34  ASP A C   1 
ATOM   238  O O   . ASP A 1 32  ? -28.68368 18.29331  -17.32012 1.000 27.97396 ? 34  ASP A O   1 
ATOM   239  C CB  . ASP A 1 32  ? -28.45194 20.36094  -15.46101 1.000 36.37364 ? 34  ASP A CB  1 
ATOM   240  C CG  . ASP A 1 32  ? -28.59884 21.35780  -16.61794 1.000 38.03088 ? 34  ASP A CG  1 
ATOM   241  O OD1 . ASP A 1 32  ? -27.65950 21.51946  -17.41691 1.000 35.16665 ? 34  ASP A OD1 1 
ATOM   242  O OD2 . ASP A 1 32  ? -29.67064 21.99305  -16.73137 1.000 45.66484 ? 34  ASP A OD2 1 
ATOM   243  N N   . VAL A 1 33  ? -26.47121 17.99847  -17.52692 1.000 26.71191 ? 35  VAL A N   1 
ATOM   244  C CA  . VAL A 1 33  ? -26.59017 17.13157  -18.69510 1.000 26.67216 ? 35  VAL A CA  1 
ATOM   245  C C   . VAL A 1 33  ? -25.81894 15.84692  -18.43059 1.000 28.95788 ? 35  VAL A C   1 
ATOM   246  O O   . VAL A 1 33  ? -24.69466 15.88374  -17.91734 1.000 27.13031 ? 35  VAL A O   1 
ATOM   247  C CB  . VAL A 1 33  ? -26.07588 17.80732  -19.98152 1.000 29.88262 ? 35  VAL A CB  1 
ATOM   248  C CG1 . VAL A 1 33  ? -26.28375 16.87457  -21.19908 1.000 28.74081 ? 35  VAL A CG1 1 
ATOM   249  C CG2 . VAL A 1 33  ? -26.76090 19.13805  -20.19973 1.000 34.40988 ? 35  VAL A CG2 1 
ATOM   250  N N   . VAL A 1 34  ? -26.42661 14.71343  -18.77584 1.000 27.48111 ? 36  VAL A N   1 
ATOM   251  C CA  . VAL A 1 34  ? -25.74985 13.41924  -18.78778 1.000 26.85998 ? 36  VAL A CA  1 
ATOM   252  C C   . VAL A 1 34  ? -25.55318 13.01479  -20.24499 1.000 28.37945 ? 36  VAL A C   1 
ATOM   253  O O   . VAL A 1 34  ? -26.52305 12.93394  -21.01232 1.000 25.99188 ? 36  VAL A O   1 
ATOM   254  C CB  . VAL A 1 34  ? -26.54297 12.35350  -18.01592 1.000 28.34083 ? 36  VAL A CB  1 
ATOM   255  C CG1 . VAL A 1 34  ? -25.91289 10.97526  -18.19123 1.000 21.44759 ? 36  VAL A CG1 1 
ATOM   256  C CG2 . VAL A 1 34  ? -26.64089 12.72955  -16.53732 1.000 25.04257 ? 36  VAL A CG2 1 
ATOM   257  N N   . TYR A 1 35  ? -24.29528 12.78044  -20.62170 1.000 23.86018 ? 37  TYR A N   1 
ATOM   258  C CA  . TYR A 1 35  ? -23.90132 12.35622  -21.95790 1.000 23.59258 ? 37  TYR A CA  1 
ATOM   259  C C   . TYR A 1 35  ? -23.64824 10.85787  -21.94690 1.000 25.37616 ? 37  TYR A C   1 
ATOM   260  O O   . TYR A 1 35  ? -22.93118 10.36012  -21.07229 1.000 26.55442 ? 37  TYR A O   1 
ATOM   261  C CB  . TYR A 1 35  ? -22.61172 13.07561  -22.39804 1.000 26.24483 ? 37  TYR A CB  1 
ATOM   262  C CG  . TYR A 1 35  ? -22.67901 14.58432  -22.33448 1.000 23.05551 ? 37  TYR A CG  1 
ATOM   263  C CD1 . TYR A 1 35  ? -22.54780 15.26105  -21.12781 1.000 25.18920 ? 37  TYR A CD1 1 
ATOM   264  C CD2 . TYR A 1 35  ? -22.88923 15.32771  -23.48749 1.000 24.81127 ? 37  TYR A CD2 1 
ATOM   265  C CE1 . TYR A 1 35  ? -22.61981 16.64101  -21.07253 1.000 24.80552 ? 37  TYR A CE1 1 
ATOM   266  C CE2 . TYR A 1 35  ? -22.96085 16.70030  -23.44900 1.000 26.70018 ? 37  TYR A CE2 1 
ATOM   267  C CZ  . TYR A 1 35  ? -22.83153 17.35108  -22.24033 1.000 28.88424 ? 37  TYR A CZ  1 
ATOM   268  O OH  . TYR A 1 35  ? -22.90708 18.71382  -22.21364 1.000 31.32122 ? 37  TYR A OH  1 
ATOM   269  N N   . CYS A 1 36  ? -24.17452 10.14622  -22.93953 1.000 22.52192 ? 38  CYS A N   1 
ATOM   270  C CA  . CYS A 1 36  ? -23.89786 8.71931   -23.05175 1.000 25.81677 ? 38  CYS A CA  1 
ATOM   271  C C   . CYS A 1 36  ? -24.08919 8.29503   -24.51046 1.000 26.24638 ? 38  CYS A C   1 
ATOM   272  O O   . CYS A 1 36  ? -24.60485 9.07486   -25.31997 1.000 22.46602 ? 38  CYS A O   1 
ATOM   273  C CB  . CYS A 1 36  ? -24.79065 7.90047   -22.10708 1.000 24.92989 ? 38  CYS A CB  1 
ATOM   274  S SG  . CYS A 1 36  ? -26.53715 7.79846   -22.63376 1.000 25.67382 ? 38  CYS A SG  1 
ATOM   275  N N   . PRO A 1 37  ? -23.59425 7.10650   -24.88990 1.000 23.21452 ? 39  PRO A N   1 
ATOM   276  C CA  . PRO A 1 37  ? -23.78686 6.64065   -26.27196 1.000 24.05844 ? 39  PRO A CA  1 
ATOM   277  C C   . PRO A 1 37  ? -25.26644 6.45936   -26.56802 1.000 27.09095 ? 39  PRO A C   1 
ATOM   278  O O   . PRO A 1 37  ? -26.02352 5.96495   -25.73151 1.000 23.04944 ? 39  PRO A O   1 
ATOM   279  C CB  . PRO A 1 37  ? -23.04973 5.29886   -26.30232 1.000 25.17971 ? 39  PRO A CB  1 
ATOM   280  C CG  . PRO A 1 37  ? -22.07035 5.36392   -25.16664 1.000 26.39460 ? 39  PRO A CG  1 
ATOM   281  C CD  . PRO A 1 37  ? -22.73318 6.19397   -24.11225 1.000 27.38278 ? 39  PRO A CD  1 
ATOM   282  N N   . ARG A 1 38  ? -25.67410 6.85912   -27.77160 1.000 23.27305 ? 40  ARG A N   1 
ATOM   283  C CA  . ARG A 1 38  ? -27.08842 6.76773   -28.10714 1.000 25.51788 ? 40  ARG A CA  1 
ATOM   284  C C   . ARG A 1 38  ? -27.55530 5.32834   -28.28021 1.000 26.72822 ? 40  ARG A C   1 
ATOM   285  O O   . ARG A 1 38  ? -28.76674 5.07781   -28.21850 1.000 26.74068 ? 40  ARG A O   1 
ATOM   286  C CB  . ARG A 1 38  ? -27.39291 7.58059   -29.36662 1.000 25.89276 ? 40  ARG A CB  1 
ATOM   287  C CG  . ARG A 1 38  ? -26.90953 6.96095   -30.66706 1.000 24.34188 ? 40  ARG A CG  1 
ATOM   288  C CD  . ARG A 1 38  ? -27.22682 7.85778   -31.85556 1.000 26.48264 ? 40  ARG A CD  1 
ATOM   289  N NE  . ARG A 1 38  ? -26.57770 7.35196   -33.06224 1.000 26.57220 ? 40  ARG A NE  1 
ATOM   290  C CZ  . ARG A 1 38  ? -26.88721 7.73921   -34.29675 1.000 28.08054 ? 40  ARG A CZ  1 
ATOM   291  N NH1 . ARG A 1 38  ? -27.83560 8.64706   -34.49117 1.000 26.41966 ? 40  ARG A NH1 1 
ATOM   292  N NH2 . ARG A 1 38  ? -26.25782 7.20283   -35.33844 1.000 26.63611 ? 40  ARG A NH2 1 
ATOM   293  N N   . HIS A 1 39  ? -26.63903 4.37257   -28.48331 1.000 23.80171 ? 41  HIS A N   1 
ATOM   294  C CA  . HIS A 1 39  ? -27.11032 2.99961   -28.62131 1.000 26.72982 ? 41  HIS A CA  1 
ATOM   295  C C   . HIS A 1 39  ? -27.64363 2.42107   -27.30813 1.000 24.98129 ? 41  HIS A C   1 
ATOM   296  O O   . HIS A 1 39  ? -28.07703 1.26691   -27.29014 1.000 27.57155 ? 41  HIS A O   1 
ATOM   297  C CB  . HIS A 1 39  ? -26.01956 2.10366   -29.24868 1.000 25.69272 ? 41  HIS A CB  1 
ATOM   298  C CG  . HIS A 1 39  ? -24.82713 1.81978   -28.37542 1.000 26.90804 ? 41  HIS A CG  1 
ATOM   299  N ND1 . HIS A 1 39  ? -24.87703 0.98186   -27.28004 1.000 27.22579 ? 41  HIS A ND1 1 
ATOM   300  C CD2 . HIS A 1 39  ? -23.53044 2.19537   -28.49532 1.000 28.50724 ? 41  HIS A CD2 1 
ATOM   301  C CE1 . HIS A 1 39  ? -23.67751 0.89317   -26.73436 1.000 29.71022 ? 41  HIS A CE1 1 
ATOM   302  N NE2 . HIS A 1 39  ? -22.83686 1.61506   -27.45755 1.000 28.21128 ? 41  HIS A NE2 1 
ATOM   303  N N   . VAL A 1 40  ? -27.67146 3.19825   -26.22278 1.000 23.78572 ? 42  VAL A N   1 
ATOM   304  C CA  . VAL A 1 40  ? -28.37850 2.75328   -25.03195 1.000 27.79674 ? 42  VAL A CA  1 
ATOM   305  C C   . VAL A 1 40  ? -29.86300 2.53910   -25.32311 1.000 26.78765 ? 42  VAL A C   1 
ATOM   306  O O   . VAL A 1 40  ? -30.51726 1.76107   -24.62364 1.000 29.54518 ? 42  VAL A O   1 
ATOM   307  C CB  . VAL A 1 40  ? -28.16654 3.75093   -23.86505 1.000 26.85812 ? 42  VAL A CB  1 
ATOM   308  C CG1 . VAL A 1 40  ? -28.85565 5.08793   -24.13772 1.000 28.81109 ? 42  VAL A CG1 1 
ATOM   309  C CG2 . VAL A 1 40  ? -28.62389 3.14007   -22.53517 1.000 27.11843 ? 42  VAL A CG2 1 
ATOM   310  N N   . ILE A 1 41  ? -30.40656 3.18021   -26.36081 1.000 26.70870 ? 43  ILE A N   1 
ATOM   311  C CA  . ILE A 1 41  ? -31.83840 3.03819   -26.65390 1.000 29.87634 ? 43  ILE A CA  1 
ATOM   312  C C   . ILE A 1 41  ? -32.10037 1.85846   -27.58867 1.000 30.13022 ? 43  ILE A C   1 
ATOM   313  O O   . ILE A 1 41  ? -33.23624 1.65453   -28.03971 1.000 32.07470 ? 43  ILE A O   1 
ATOM   314  C CB  . ILE A 1 41  ? -32.42360 4.33723   -27.24090 1.000 26.87850 ? 43  ILE A CB  1 
ATOM   315  C CG1 . ILE A 1 41  ? -31.85968 4.61326   -28.63920 1.000 25.80883 ? 43  ILE A CG1 1 
ATOM   316  C CG2 . ILE A 1 41  ? -32.20209 5.51779   -26.28933 1.000 27.60670 ? 43  ILE A CG2 1 
ATOM   317  C CD1 . ILE A 1 41  ? -32.42006 5.85976   -29.30574 1.000 26.48212 ? 43  ILE A CD1 1 
ATOM   318  N N   . CYS A 1 42  ? -31.06007 1.07749   -27.89639 1.000 33.79787 ? 44  CYS A N   1 
ATOM   319  C CA  . CYS A 1 42  ? -31.20045 -0.12201  -28.71840 1.000 33.25665 ? 44  CYS A CA  1 
ATOM   320  C C   . CYS A 1 42  ? -31.58984 -1.32827  -27.87491 1.000 39.19418 ? 44  CYS A C   1 
ATOM   321  O O   . CYS A 1 42  ? -31.04986 -1.53804  -26.78824 1.000 41.79627 ? 44  CYS A O   1 
ATOM   322  C CB  . CYS A 1 42  ? -29.89659 -0.43611  -29.45109 1.000 33.03139 ? 44  CYS A CB  1 
ATOM   323  S SG  . CYS A 1 42  ? -29.56109 0.72790   -30.74075 1.000 33.23863 ? 44  CYS A SG  1 
ATOM   324  N N   . THR A 1 43  ? -32.52228 -2.12677  -28.38606 1.000 38.99551 ? 45  THR A N   1 
ATOM   325  C CA  . THR A 1 43  ? -32.75086 -3.46474  -27.86186 1.000 43.86336 ? 45  THR A CA  1 
ATOM   326  C C   . THR A 1 43  ? -31.96657 -4.45910  -28.70688 1.000 42.66630 ? 45  THR A C   1 
ATOM   327  O O   . THR A 1 43  ? -31.25759 -4.08851  -29.64395 1.000 45.29221 ? 45  THR A O   1 
ATOM   328  C CB  . THR A 1 43  ? -34.23603 -3.83056  -27.85601 1.000 43.03875 ? 45  THR A CB  1 
ATOM   329  O OG1 . THR A 1 43  ? -34.64359 -4.16202  -29.18915 1.000 43.98779 ? 45  THR A OG1 1 
ATOM   330  C CG2 . THR A 1 43  ? -35.08733 -2.68171  -27.33206 1.000 44.42474 ? 45  THR A CG2 1 
ATOM   331  N N   . SER A 1 44  ? -32.11129 -5.74408  -28.37877 1.000 43.12303 ? 46  SER A N   1 
ATOM   332  C CA  . SER A 1 44  ? -31.36622 -6.77762  -29.09088 1.000 45.08360 ? 46  SER A CA  1 
ATOM   333  C C   . SER A 1 44  ? -31.73365 -6.81107  -30.57141 1.000 44.82881 ? 46  SER A C   1 
ATOM   334  O O   . SER A 1 44  ? -30.87929 -7.07903  -31.42444 1.000 45.99903 ? 46  SER A O   1 
ATOM   335  C CB  . SER A 1 44  ? -31.61132 -8.14185  -28.44186 1.000 45.47875 ? 46  SER A CB  1 
ATOM   336  O OG  . SER A 1 44  ? -32.91601 -8.62407  -28.72114 1.000 51.96721 ? 46  SER A OG  1 
ATOM   337  N N   . GLU A 1 45  ? -32.99622 -6.52678  -30.89916 1.000 46.14576 ? 47  GLU A N   1 
ATOM   338  C CA  . GLU A 1 45  ? -33.45903 -6.52815  -32.28453 1.000 44.12146 ? 47  GLU A CA  1 
ATOM   339  C C   . GLU A 1 45  ? -33.01194 -5.29566  -33.06844 1.000 44.39266 ? 47  GLU A C   1 
ATOM   340  O O   . GLU A 1 45  ? -33.30741 -5.19802  -34.26593 1.000 41.17850 ? 47  GLU A O   1 
ATOM   341  C CB  . GLU A 1 45  ? -34.98820 -6.63008  -32.32181 1.000 47.65593 ? 47  GLU A CB  1 
ATOM   342  C CG  . GLU A 1 45  ? -35.57058 -7.87862  -31.64041 1.000 53.60766 ? 47  GLU A CG  1 
ATOM   343  C CD  . GLU A 1 45  ? -34.83179 -9.16021  -32.01078 1.000 56.70783 ? 47  GLU A CD  1 
ATOM   344  O OE1 . GLU A 1 45  ? -34.00186 -9.64140  -31.19149 1.000 59.49080 ? 47  GLU A OE1 1 
ATOM   345  O OE2 . GLU A 1 45  ? -35.07732 -9.67885  -33.12288 1.000 58.91173 ? 47  GLU A OE2 1 
ATOM   346  N N   . ASP A 1 46  ? -32.30026 -4.36265  -32.43423 1.000 37.90687 ? 48  ASP A N   1 
ATOM   347  C CA  . ASP A 1 46  ? -31.98482 -3.08493  -33.04654 1.000 35.12193 ? 48  ASP A CA  1 
ATOM   348  C C   . ASP A 1 46  ? -30.52331 -2.93434  -33.43697 1.000 38.18666 ? 48  ASP A C   1 
ATOM   349  O O   . ASP A 1 46  ? -30.18595 -1.94775  -34.09273 1.000 38.98254 ? 48  ASP A O   1 
ATOM   350  C CB  . ASP A 1 46  ? -32.36195 -1.94002  -32.09615 1.000 36.85922 ? 48  ASP A CB  1 
ATOM   351  C CG  . ASP A 1 46  ? -33.83848 -1.93796  -31.73467 1.000 42.71026 ? 48  ASP A CG  1 
ATOM   352  O OD1 . ASP A 1 46  ? -34.67223 -1.97602  -32.66565 1.000 39.62962 ? 48  ASP A OD1 1 
ATOM   353  O OD2 . ASP A 1 46  ? -34.16007 -1.89847  -30.52311 1.000 40.67427 ? 48  ASP A OD2 1 
ATOM   354  N N   . MET A 1 47  ? -29.65987 -3.88811  -33.07848 1.000 32.45390 ? 49  MET A N   1 
ATOM   355  C CA  . MET A 1 47  ? -28.21849 -3.67824  -33.19878 1.000 39.42274 ? 49  MET A CA  1 
ATOM   356  C C   . MET A 1 47  ? -27.76016 -3.67211  -34.65174 1.000 31.21034 ? 49  MET A C   1 
ATOM   357  O O   . MET A 1 47  ? -26.85235 -2.91999  -35.01737 1.000 31.63762 ? 49  MET A O   1 
ATOM   358  C CB  . MET A 1 47  ? -27.46945 -4.75382  -32.41249 1.000 38.23620 ? 49  MET A CB  1 
ATOM   359  N N   . LEU A 1 48  ? -28.36968 -4.49663  -35.49705 1.000 32.51670 ? 50  LEU A N   1 
ATOM   360  C CA  . LEU A 1 48  ? -27.85588 -4.63519  -36.85362 1.000 30.85816 ? 50  LEU A CA  1 
ATOM   361  C C   . LEU A 1 48  ? -28.23215 -3.44849  -37.73969 1.000 32.69324 ? 50  LEU A C   1 
ATOM   362  O O   . LEU A 1 48  ? -27.42088 -3.01663  -38.56239 1.000 30.97466 ? 50  LEU A O   1 
ATOM   363  C CB  . LEU A 1 48  ? -28.35007 -5.94857  -37.45881 1.000 34.27566 ? 50  LEU A CB  1 
ATOM   364  C CG  . LEU A 1 48  ? -27.75748 -7.22077  -36.85313 1.000 37.82319 ? 50  LEU A CG  1 
ATOM   365  C CD1 . LEU A 1 48  ? -28.60991 -8.43783  -37.22441 1.000 41.45293 ? 50  LEU A CD1 1 
ATOM   366  C CD2 . LEU A 1 48  ? -26.30562 -7.41727  -37.27571 1.000 41.64676 ? 50  LEU A CD2 1 
ATOM   367  N N   . ASN A 1 49  ? -29.45045 -2.90729  -37.61288 1.000 26.33147 ? 51  ASN A N   1 
ATOM   368  C CA  . ASN A 1 49  ? -29.88048 -1.77754  -38.44305 1.000 28.96600 ? 51  ASN A CA  1 
ATOM   369  C C   . ASN A 1 49  ? -30.70626 -0.78645  -37.63088 1.000 32.11961 ? 51  ASN A C   1 
ATOM   370  O O   . ASN A 1 49  ? -31.86469 -0.51142  -37.94960 1.000 27.93238 ? 51  ASN A O   1 
ATOM   371  C CB  . ASN A 1 49  ? -30.65955 -2.28049  -39.65879 1.000 29.24578 ? 51  ASN A CB  1 
ATOM   372  C CG  . ASN A 1 49  ? -29.78280 -3.08577  -40.58936 1.000 29.84121 ? 51  ASN A CG  1 
ATOM   373  O OD1 . ASN A 1 49  ? -28.94103 -2.52450  -41.29308 1.000 29.76689 ? 51  ASN A OD1 1 
ATOM   374  N ND2 . ASN A 1 49  ? -29.94762 -4.40416  -40.57384 1.000 26.19493 ? 51  ASN A ND2 1 
ATOM   375  N N   . PRO A 1 50  ? -30.10856 -0.17486  -36.61081 1.000 30.73135 ? 52  PRO A N   1 
ATOM   376  C CA  . PRO A 1 50  ? -30.87382 0.74450   -35.76244 1.000 31.06006 ? 52  PRO A CA  1 
ATOM   377  C C   . PRO A 1 50  ? -31.27676 1.99100   -36.52843 1.000 28.82365 ? 52  PRO A C   1 
ATOM   378  O O   . PRO A 1 50  ? -30.51944 2.52715   -37.34400 1.000 27.51067 ? 52  PRO A O   1 
ATOM   379  C CB  . PRO A 1 50  ? -29.90100 1.07487   -34.62324 1.000 29.96896 ? 52  PRO A CB  1 
ATOM   380  C CG  . PRO A 1 50  ? -28.54331 0.92903   -35.27131 1.000 30.95020 ? 52  PRO A CG  1 
ATOM   381  C CD  . PRO A 1 50  ? -28.68094 -0.20843  -36.24349 1.000 30.56170 ? 52  PRO A CD  1 
ATOM   382  N N   . ASN A 1 51  ? -32.50858 2.42234   -36.28913 1.000 24.17630 ? 53  ASN A N   1 
ATOM   383  C CA  . ASN A 1 51  ? -33.02413 3.67052   -36.82419 1.000 28.44794 ? 53  ASN A CA  1 
ATOM   384  C C   . ASN A 1 51  ? -33.16356 4.60474   -35.62822 1.000 30.45359 ? 53  ASN A C   1 
ATOM   385  O O   . ASN A 1 51  ? -34.19180 4.61482   -34.95306 1.000 25.53398 ? 53  ASN A O   1 
ATOM   386  C CB  . ASN A 1 51  ? -34.36442 3.45933   -37.53204 1.000 28.79829 ? 53  ASN A CB  1 
ATOM   387  C CG  . ASN A 1 51  ? -34.84778 4.70288   -38.21959 1.000 32.72467 ? 53  ASN A CG  1 
ATOM   388  O OD1 . ASN A 1 51  ? -34.73561 5.81443   -37.68626 1.000 31.50169 ? 53  ASN A OD1 1 
ATOM   389  N ND2 . ASN A 1 51  ? -35.40487 4.53069   -39.41375 1.000 41.44049 ? 53  ASN A ND2 1 
ATOM   390  N N   . TYR A 1 52  ? -32.12842 5.41209   -35.37977 1.000 27.54704 ? 54  TYR A N   1 
ATOM   391  C CA  . TYR A 1 52  ? -32.05020 6.08657   -34.09092 1.000 26.34089 ? 54  TYR A CA  1 
ATOM   392  C C   . TYR A 1 52  ? -33.10572 7.17554   -33.95824 1.000 27.62241 ? 54  TYR A C   1 
ATOM   393  O O   . TYR A 1 52  ? -33.61996 7.41025   -32.86023 1.000 29.64613 ? 54  TYR A O   1 
ATOM   394  C CB  . TYR A 1 52  ? -30.64796 6.65309   -33.88120 1.000 27.16652 ? 54  TYR A CB  1 
ATOM   395  C CG  . TYR A 1 52  ? -29.64098 5.59955   -33.49696 1.000 25.53829 ? 54  TYR A CG  1 
ATOM   396  C CD1 . TYR A 1 52  ? -29.63116 5.05069   -32.21874 1.000 25.35181 ? 54  TYR A CD1 1 
ATOM   397  C CD2 . TYR A 1 52  ? -28.72094 5.12845   -34.42253 1.000 24.22566 ? 54  TYR A CD2 1 
ATOM   398  C CE1 . TYR A 1 52  ? -28.71076 4.09036   -31.87148 1.000 26.57953 ? 54  TYR A CE1 1 
ATOM   399  C CE2 . TYR A 1 52  ? -27.79527 4.16701   -34.08295 1.000 27.30810 ? 54  TYR A CE2 1 
ATOM   400  C CZ  . TYR A 1 52  ? -27.78941 3.65086   -32.81111 1.000 27.52433 ? 54  TYR A CZ  1 
ATOM   401  O OH  . TYR A 1 52  ? -26.86357 2.69406   -32.48107 1.000 30.02892 ? 54  TYR A OH  1 
ATOM   402  N N   . GLU A 1 53  ? -33.43349 7.85929   -35.05238 1.000 27.27284 ? 55  GLU A N   1 
ATOM   403  C CA  . GLU A 1 53  ? -34.46993 8.88163   -34.98118 1.000 28.13025 ? 55  GLU A CA  1 
ATOM   404  C C   . GLU A 1 53  ? -35.81313 8.25769   -34.60209 1.000 28.17915 ? 55  GLU A C   1 
ATOM   405  O O   . GLU A 1 53  ? -36.57374 8.82419   -33.80527 1.000 27.93779 ? 55  GLU A O   1 
ATOM   406  C CB  . GLU A 1 53  ? -34.55158 9.62582   -36.31636 1.000 29.18323 ? 55  GLU A CB  1 
ATOM   407  C CG  . GLU A 1 53  ? -33.27601 10.41715  -36.67439 1.000 40.13956 ? 55  GLU A CG  1 
ATOM   408  C CD  . GLU A 1 53  ? -32.12412 9.53464   -37.20339 1.000 44.77400 ? 55  GLU A CD  1 
ATOM   409  O OE1 . GLU A 1 53  ? -32.35837 8.33990   -37.54430 1.000 37.06440 ? 55  GLU A OE1 1 
ATOM   410  O OE2 . GLU A 1 53  ? -30.96618 10.04256  -37.25817 1.000 52.35267 ? 55  GLU A OE2 1 
ATOM   411  N N   . ASP A 1 54  ? -36.08400 7.05849   -35.11622 1.000 29.66198 ? 56  ASP A N   1 
ATOM   412  C CA  . ASP A 1 54  ? -37.32793 6.36782   -34.80032 1.000 29.59030 ? 56  ASP A CA  1 
ATOM   413  C C   . ASP A 1 54  ? -37.31492 5.81627   -33.38114 1.000 33.09139 ? 56  ASP A C   1 
ATOM   414  O O   . ASP A 1 54  ? -38.33108 5.87515   -32.67140 1.000 26.14544 ? 56  ASP A O   1 
ATOM   415  C CB  . ASP A 1 54  ? -37.56956 5.24495   -35.80261 1.000 31.24225 ? 56  ASP A CB  1 
ATOM   416  C CG  . ASP A 1 54  ? -38.86601 4.49069   -35.52275 1.000 36.12363 ? 56  ASP A CG  1 
ATOM   417  O OD1 . ASP A 1 54  ? -39.94872 5.01635   -35.85905 1.000 33.18391 ? 56  ASP A OD1 1 
ATOM   418  O OD2 . ASP A 1 54  ? -38.79061 3.37965   -34.96502 1.000 40.80870 ? 56  ASP A OD2 1 
ATOM   419  N N   . LEU A 1 55  ? -36.17825 5.26538   -32.94543 1.000 26.93504 ? 57  LEU A N   1 
ATOM   420  C CA  . LEU A 1 55  ? -36.11163 4.73364   -31.59051 1.000 28.06417 ? 57  LEU A CA  1 
ATOM   421  C C   . LEU A 1 55  ? -36.27156 5.84288   -30.56217 1.000 24.86094 ? 57  LEU A C   1 
ATOM   422  O O   . LEU A 1 55  ? -36.89266 5.64495   -29.51234 1.000 27.19848 ? 57  LEU A O   1 
ATOM   423  C CB  . LEU A 1 55  ? -34.78327 3.99195   -31.37592 1.000 28.99572 ? 57  LEU A CB  1 
ATOM   424  C CG  . LEU A 1 55  ? -34.57417 2.67792   -32.13952 1.000 32.46953 ? 57  LEU A CG  1 
ATOM   425  C CD1 . LEU A 1 55  ? -33.09624 2.24664   -32.08954 1.000 32.67176 ? 57  LEU A CD1 1 
ATOM   426  C CD2 . LEU A 1 55  ? -35.49590 1.55820   -31.62937 1.000 32.32889 ? 57  LEU A CD2 1 
ATOM   427  N N   . LEU A 1 56  ? -35.71080 7.01981   -30.84554 1.000 28.70525 ? 58  LEU A N   1 
ATOM   428  C CA  . LEU A 1 56  ? -35.66964 8.08794   -29.85292 1.000 26.93882 ? 58  LEU A CA  1 
ATOM   429  C C   . LEU A 1 56  ? -37.01458 8.79546   -29.73540 1.000 29.15137 ? 58  LEU A C   1 
ATOM   430  O O   . LEU A 1 56  ? -37.43177 9.15380   -28.62806 1.000 28.52100 ? 58  LEU A O   1 
ATOM   431  C CB  . LEU A 1 56  ? -34.57641 9.09837   -30.20139 1.000 27.26870 ? 58  LEU A CB  1 
ATOM   432  C CG  . LEU A 1 56  ? -34.37893 10.19160  -29.14486 1.000 29.81552 ? 58  LEU A CG  1 
ATOM   433  C CD1 . LEU A 1 56  ? -34.02633 9.56731   -27.80939 1.000 30.66972 ? 58  LEU A CD1 1 
ATOM   434  C CD2 . LEU A 1 56  ? -33.31298 11.18533  -29.57441 1.000 33.36121 ? 58  LEU A CD2 1 
ATOM   435  N N   . ILE A 1 57  ? -37.70710 9.00008   -30.85893 1.000 27.34372 ? 59  ILE A N   1 
ATOM   436  C CA  . ILE A 1 57  ? -38.98371 9.70665   -30.80654 1.000 29.20547 ? 59  ILE A CA  1 
ATOM   437  C C   . ILE A 1 57  ? -39.99640 8.95572   -29.95572 1.000 28.63073 ? 59  ILE A C   1 
ATOM   438  O O   . ILE A 1 57  ? -40.92028 9.56850   -29.41262 1.000 30.97240 ? 59  ILE A O   1 
ATOM   439  C CB  . ILE A 1 57  ? -39.51803 9.97575   -32.23074 1.000 32.05820 ? 59  ILE A CB  1 
ATOM   440  C CG1 . ILE A 1 57  ? -40.54662 11.11771  -32.20338 1.000 32.41913 ? 59  ILE A CG1 1 
ATOM   441  C CG2 . ILE A 1 57  ? -40.10202 8.71595   -32.84885 1.000 26.96861 ? 59  ILE A CG2 1 
ATOM   442  C CD1 . ILE A 1 57  ? -40.96867 11.58900  -33.59419 1.000 36.11442 ? 59  ILE A CD1 1 
ATOM   443  N N   . ARG A 1 58  ? -39.82122 7.64393   -29.78708 1.000 27.15672 ? 60  ARG A N   1 
ATOM   444  C CA  . ARG A 1 58  ? -40.71412 6.82189   -28.98184 1.000 29.98676 ? 60  ARG A CA  1 
ATOM   445  C C   . ARG A 1 58  ? -40.39248 6.84808   -27.49321 1.000 31.89132 ? 60  ARG A C   1 
ATOM   446  O O   . ARG A 1 58  ? -41.14117 6.25254   -26.70541 1.000 30.98521 ? 60  ARG A O   1 
ATOM   447  C CB  . ARG A 1 58  ? -40.68433 5.37898   -29.47944 1.000 27.78802 ? 60  ARG A CB  1 
ATOM   448  C CG  . ARG A 1 58  ? -41.01688 5.22220   -30.94802 1.000 24.90580 ? 60  ARG A CG  1 
ATOM   449  C CD  . ARG A 1 58  ? -40.81562 3.77341   -31.37553 1.000 26.46840 ? 60  ARG A CD  1 
ATOM   450  N NE  . ARG A 1 58  ? -40.95731 3.62557   -32.81669 1.000 28.39862 ? 60  ARG A NE  1 
ATOM   451  C CZ  . ARG A 1 58  ? -42.12066 3.38053   -33.40950 1.000 30.20114 ? 60  ARG A CZ  1 
ATOM   452  N NH1 . ARG A 1 58  ? -43.21180 3.25916   -32.66232 1.000 25.96519 ? 60  ARG A NH1 1 
ATOM   453  N NH2 . ARG A 1 58  ? -42.18913 3.26530   -34.73195 1.000 27.60317 ? 60  ARG A NH2 1 
ATOM   454  N N   . LYS A 1 59  ? -39.32289 7.52286   -27.08556 1.000 29.69535 ? 61  LYS A N   1 
ATOM   455  C CA  . LYS A 1 59  ? -38.92894 7.55377   -25.68726 1.000 33.10227 ? 61  LYS A CA  1 
ATOM   456  C C   . LYS A 1 59  ? -39.48820 8.78869   -24.99860 1.000 29.66446 ? 61  LYS A C   1 
ATOM   457  O O   . LYS A 1 59  ? -39.59853 9.86247   -25.59181 1.000 32.31689 ? 61  LYS A O   1 
ATOM   458  C CB  . LYS A 1 59  ? -37.39745 7.54300   -25.54574 1.000 30.17316 ? 61  LYS A CB  1 
ATOM   459  C CG  . LYS A 1 59  ? -36.73402 6.33397   -26.16632 1.000 33.26867 ? 61  LYS A CG  1 
ATOM   460  C CD  . LYS A 1 59  ? -37.08394 5.04931   -25.41480 1.000 36.01148 ? 61  LYS A CD  1 
ATOM   461  C CE  . LYS A 1 59  ? -36.80850 3.82142   -26.27360 1.000 36.59191 ? 61  LYS A CE  1 
ATOM   462  N NZ  . LYS A 1 59  ? -36.58650 2.62090   -25.41771 1.000 46.23919 ? 61  LYS A NZ  1 
ATOM   463  N N   . SER A 1 60  ? -39.83036 8.62265   -23.72998 1.000 31.29104 ? 62  SER A N   1 
ATOM   464  C CA  . SER A 1 60  ? -40.08207 9.73391   -22.83036 1.000 33.79554 ? 62  SER A CA  1 
ATOM   465  C C   . SER A 1 60  ? -38.93602 9.85173   -21.83266 1.000 33.67306 ? 62  SER A C   1 
ATOM   466  O O   . SER A 1 60  ? -38.08214 8.97073   -21.71606 1.000 32.47564 ? 62  SER A O   1 
ATOM   467  C CB  . SER A 1 60  ? -41.40651 9.54546   -22.08955 1.000 41.50210 ? 62  SER A CB  1 
ATOM   468  O OG  . SER A 1 60  ? -41.35761 8.32109   -21.38145 1.000 46.25345 ? 62  SER A OG  1 
ATOM   469  N N   . ASN A 1 61  ? -38.94092 10.96126  -21.09829 1.000 32.50006 ? 63  ASN A N   1 
ATOM   470  C CA  . ASN A 1 61  ? -37.93920 11.17529  -20.06240 1.000 36.94118 ? 63  ASN A CA  1 
ATOM   471  C C   . ASN A 1 61  ? -37.90157 10.02694  -19.06323 1.000 36.18745 ? 63  ASN A C   1 
ATOM   472  O O   . ASN A 1 61  ? -36.82013 9.53535   -18.70623 1.000 34.66692 ? 63  ASN A O   1 
ATOM   473  C CB  . ASN A 1 61  ? -38.21636 12.50488  -19.37246 1.000 34.42733 ? 63  ASN A CB  1 
ATOM   474  C CG  . ASN A 1 61  ? -37.97586 13.66992  -20.28997 1.000 35.67731 ? 63  ASN A CG  1 
ATOM   475  O OD1 . ASN A 1 61  ? -37.15004 13.58652  -21.21170 1.000 36.20630 ? 63  ASN A OD1 1 
ATOM   476  N ND2 . ASN A 1 61  ? -38.67458 14.76693  -20.05371 1.000 33.83121 ? 63  ASN A ND2 1 
ATOM   477  N N   . HIS A 1 62  ? -39.07000 9.55996   -18.61939 1.000 35.32533 ? 64  HIS A N   1 
ATOM   478  C CA  . HIS A 1 62  ? -39.09816 8.50964   -17.60702 1.000 33.91275 ? 64  HIS A CA  1 
ATOM   479  C C   . HIS A 1 62  ? -38.60627 7.15733   -18.12481 1.000 32.79020 ? 64  HIS A C   1 
ATOM   480  O O   . HIS A 1 62  ? -38.42692 6.24015   -17.31896 1.000 33.91398 ? 64  HIS A O   1 
ATOM   481  C CB  . HIS A 1 62  ? -40.51679 8.38081   -17.02205 1.000 35.62845 ? 64  HIS A CB  1 
ATOM   482  C CG  . HIS A 1 62  ? -41.55710 7.99733   -18.02781 1.000 37.86888 ? 64  HIS A CG  1 
ATOM   483  N ND1 . HIS A 1 62  ? -41.78099 6.68984   -18.40965 1.000 45.88191 ? 64  HIS A ND1 1 
ATOM   484  C CD2 . HIS A 1 62  ? -42.44203 8.74908   -18.72816 1.000 43.83515 ? 64  HIS A CD2 1 
ATOM   485  C CE1 . HIS A 1 62  ? -42.75440 6.65258   -19.30551 1.000 40.85470 ? 64  HIS A CE1 1 
ATOM   486  N NE2 . HIS A 1 62  ? -43.17167 7.88937   -19.51759 1.000 41.78942 ? 64  HIS A NE2 1 
ATOM   487  N N   . ASN A 1 63  ? -38.37796 6.99762   -19.43281 1.000 33.18957 ? 65  ASN A N   1 
ATOM   488  C CA  . ASN A 1 63  ? -37.76462 5.76068   -19.91577 1.000 33.20075 ? 65  ASN A CA  1 
ATOM   489  C C   . ASN A 1 63  ? -36.27263 5.67564   -19.59049 1.000 32.80212 ? 65  ASN A C   1 
ATOM   490  O O   . ASN A 1 63  ? -35.69564 4.58279   -19.69223 1.000 32.86808 ? 65  ASN A O   1 
ATOM   491  C CB  . ASN A 1 63  ? -37.95603 5.61414   -21.43079 1.000 30.94642 ? 65  ASN A CB  1 
ATOM   492  C CG  . ASN A 1 63  ? -39.39761 5.32815   -21.82277 1.000 36.65188 ? 65  ASN A CG  1 
ATOM   493  O OD1 . ASN A 1 63  ? -39.91657 5.90812   -22.78264 1.000 33.70892 ? 65  ASN A OD1 1 
ATOM   494  N ND2 . ASN A 1 63  ? -40.05501 4.42902   -21.08060 1.000 34.93295 ? 65  ASN A ND2 1 
ATOM   495  N N   . PHE A 1 64  ? -35.64226 6.78384   -19.19717 1.000 31.93371 ? 66  PHE A N   1 
ATOM   496  C CA  . PHE A 1 64  ? -34.21169 6.81733   -18.87786 1.000 30.23409 ? 66  PHE A CA  1 
ATOM   497  C C   . PHE A 1 64  ? -34.00526 6.84001   -17.36661 1.000 32.34297 ? 66  PHE A C   1 
ATOM   498  O O   . PHE A 1 64  ? -34.40792 7.79700   -16.69706 1.000 38.11174 ? 66  PHE A O   1 
ATOM   499  C CB  . PHE A 1 64  ? -33.54896 8.03949   -19.51185 1.000 29.64333 ? 66  PHE A CB  1 
ATOM   500  C CG  . PHE A 1 64  ? -33.65733 8.07713   -21.01249 1.000 31.54177 ? 66  PHE A CG  1 
ATOM   501  C CD1 . PHE A 1 64  ? -32.78109 7.34002   -21.80099 1.000 32.61957 ? 66  PHE A CD1 1 
ATOM   502  C CD2 . PHE A 1 64  ? -34.63913 8.84534   -21.63257 1.000 28.35290 ? 66  PHE A CD2 1 
ATOM   503  C CE1 . PHE A 1 64  ? -32.87544 7.36644   -23.18725 1.000 31.50502 ? 66  PHE A CE1 1 
ATOM   504  C CE2 . PHE A 1 64  ? -34.74194 8.88291   -23.01841 1.000 30.95965 ? 66  PHE A CE2 1 
ATOM   505  C CZ  . PHE A 1 64  ? -33.85748 8.13805   -23.79693 1.000 30.61637 ? 66  PHE A CZ  1 
ATOM   506  N N   . LEU A 1 65  ? -33.37988 5.79684   -16.83337 1.000 26.46508 ? 67  LEU A N   1 
ATOM   507  C CA  . LEU A 1 65  ? -33.04092 5.72798   -15.41710 1.000 30.54740 ? 67  LEU A CA  1 
ATOM   508  C C   . LEU A 1 65  ? -31.56314 6.06886   -15.25799 1.000 34.10552 ? 67  LEU A C   1 
ATOM   509  O O   . LEU A 1 65  ? -30.70002 5.35889   -15.78788 1.000 30.30341 ? 67  LEU A O   1 
ATOM   510  C CB  . LEU A 1 65  ? -33.35161 4.34080   -14.85061 1.000 36.36104 ? 67  LEU A CB  1 
ATOM   511  C CG  . LEU A 1 65  ? -32.72919 3.89008   -13.52048 1.000 40.49135 ? 67  LEU A CG  1 
ATOM   512  C CD1 . LEU A 1 65  ? -33.01373 4.86039   -12.37104 1.000 41.08739 ? 67  LEU A CD1 1 
ATOM   513  C CD2 . LEU A 1 65  ? -33.19756 2.48519   -13.16805 1.000 44.74080 ? 67  LEU A CD2 1 
ATOM   514  N N   . VAL A 1 66  ? -31.28051 7.16496   -14.55606 1.000 30.16544 ? 68  VAL A N   1 
ATOM   515  C CA  . VAL A 1 66  ? -29.92036 7.63975   -14.32026 1.000 31.24036 ? 68  VAL A CA  1 
ATOM   516  C C   . VAL A 1 66  ? -29.63365 7.53005   -12.83125 1.000 32.99717 ? 68  VAL A C   1 
ATOM   517  O O   . VAL A 1 66  ? -30.40551 8.03191   -12.00580 1.000 29.38868 ? 68  VAL A O   1 
ATOM   518  C CB  . VAL A 1 66  ? -29.73264 9.08325   -14.82102 1.000 26.88667 ? 68  VAL A CB  1 
ATOM   519  C CG1 . VAL A 1 66  ? -28.29320 9.55911   -14.59173 1.000 30.37093 ? 68  VAL A CG1 1 
ATOM   520  C CG2 . VAL A 1 66  ? -30.09432 9.17854   -16.30858 1.000 27.71435 ? 68  VAL A CG2 1 
ATOM   521  N N   . GLN A 1 67  ? -28.53948 6.85439   -12.48625 1.000 30.38698 ? 69  GLN A N   1 
ATOM   522  C CA  . GLN A 1 67  ? -28.17096 6.61650   -11.09549 1.000 35.16457 ? 69  GLN A CA  1 
ATOM   523  C C   . GLN A 1 67  ? -26.77376 7.16641   -10.84985 1.000 34.27541 ? 69  GLN A C   1 
ATOM   524  O O   . GLN A 1 67  ? -25.81322 6.73536   -11.49670 1.000 29.18184 ? 69  GLN A O   1 
ATOM   525  C CB  . GLN A 1 67  ? -28.23366 5.12358   -10.74628 1.000 32.25387 ? 69  GLN A CB  1 
ATOM   526  C CG  . GLN A 1 67  ? -29.61353 4.50952   -10.94058 1.000 42.81951 ? 69  GLN A CG  1 
ATOM   527  C CD  . GLN A 1 67  ? -29.60967 2.98882   -10.91696 1.000 52.61145 ? 69  GLN A CD  1 
ATOM   528  O OE1 . GLN A 1 67  ? -29.98653 2.33690   -11.89686 1.000 53.42288 ? 69  GLN A OE1 1 
ATOM   529  N NE2 . GLN A 1 67  ? -29.19755 2.41568   -9.78869  1.000 57.63201 ? 69  GLN A NE2 1 
ATOM   530  N N   . ALA A 1 68  ? -26.67205 8.13271   -9.93660  1.000 34.52386 ? 70  ALA A N   1 
ATOM   531  C CA  . ALA A 1 68  ? -25.39094 8.68006   -9.48917  1.000 35.91242 ? 70  ALA A CA  1 
ATOM   532  C C   . ALA A 1 68  ? -25.14474 8.10122   -8.10570  1.000 40.40875 ? 70  ALA A C   1 
ATOM   533  O O   . ALA A 1 68  ? -25.67722 8.59890   -7.10905  1.000 41.04905 ? 70  ALA A O   1 
ATOM   534  C CB  . ALA A 1 68  ? -25.41289 10.20435  -9.46650  1.000 34.90641 ? 70  ALA A CB  1 
ATOM   535  N N   . GLY A 1 69  ? -24.35313 7.03792   -8.04512  1.000 43.47281 ? 71  GLY A N   1 
ATOM   536  C CA  . GLY A 1 69  ? -24.19801 6.32612   -6.79466  1.000 48.86851 ? 71  GLY A CA  1 
ATOM   537  C C   . GLY A 1 69  ? -25.51419 5.71656   -6.36661  1.000 46.02486 ? 71  GLY A C   1 
ATOM   538  O O   . GLY A 1 69  ? -26.10413 4.93336   -7.11820  1.000 49.52826 ? 71  GLY A O   1 
ATOM   539  N N   . ASN A 1 70  ? -26.00078 6.08253   -5.17995  1.000 49.35595 ? 72  ASN A N   1 
ATOM   540  C CA  . ASN A 1 70  ? -27.27552 5.58325   -4.68288  1.000 49.01272 ? 72  ASN A CA  1 
ATOM   541  C C   . ASN A 1 70  ? -28.41853 6.57170   -4.88996  1.000 52.52915 ? 72  ASN A C   1 
ATOM   542  O O   . ASN A 1 70  ? -29.50028 6.37082   -4.32964  1.000 53.63088 ? 72  ASN A O   1 
ATOM   543  C CB  . ASN A 1 70  ? -27.16480 5.21938   -3.19780  1.000 52.26338 ? 72  ASN A CB  1 
ATOM   544  N N   . VAL A 1 71  ? -28.21307 7.62607   -5.67953  1.000 46.36906 ? 73  VAL A N   1 
ATOM   545  C CA  . VAL A 1 71  ? -29.22550 8.65194   -5.91000  1.000 43.57221 ? 73  VAL A CA  1 
ATOM   546  C C   . VAL A 1 71  ? -29.72330 8.55083   -7.34543  1.000 42.59942 ? 73  VAL A C   1 
ATOM   547  O O   . VAL A 1 71  ? -28.92101 8.54699   -8.28811  1.000 38.59250 ? 73  VAL A O   1 
ATOM   548  C CB  . VAL A 1 71  ? -28.67280 10.05871  -5.62872  1.000 42.99523 ? 73  VAL A CB  1 
ATOM   549  C CG1 . VAL A 1 71  ? -29.66751 11.12379  -6.08991  1.000 45.74252 ? 73  VAL A CG1 1 
ATOM   550  C CG2 . VAL A 1 71  ? -28.36356 10.21515  -4.15221  1.000 50.49015 ? 73  VAL A CG2 1 
ATOM   551  N N   . GLN A 1 72  ? -31.04534 8.49287   -7.51395  1.000 38.21437 ? 74  GLN A N   1 
ATOM   552  C CA  . GLN A 1 72  ? -31.64050 8.56968   -8.84241  1.000 35.14741 ? 74  GLN A CA  1 
ATOM   553  C C   . GLN A 1 72  ? -31.75313 10.02798  -9.26781  1.000 36.47262 ? 74  GLN A C   1 
ATOM   554  O O   . GLN A 1 72  ? -32.27314 10.86130  -8.51893  1.000 39.39814 ? 74  GLN A O   1 
ATOM   555  C CB  . GLN A 1 72  ? -33.02335 7.90347   -8.85971  1.000 36.35792 ? 74  GLN A CB  1 
ATOM   556  N N   . LEU A 1 73  ? -31.26203 10.34152  -10.46544 1.000 29.96772 ? 75  LEU A N   1 
ATOM   557  C CA  . LEU A 1 73  ? -31.45551 11.66070  -11.05454 1.000 32.98210 ? 75  LEU A CA  1 
ATOM   558  C C   . LEU A 1 73  ? -32.67253 11.62824  -11.96604 1.000 37.46788 ? 75  LEU A C   1 
ATOM   559  O O   . LEU A 1 73  ? -32.84328 10.69119  -12.75030 1.000 40.91482 ? 75  LEU A O   1 
ATOM   560  C CB  . LEU A 1 73  ? -30.23120 12.10364  -11.86108 1.000 34.57472 ? 75  LEU A CB  1 
ATOM   561  C CG  . LEU A 1 73  ? -28.84863 11.94138  -11.23898 1.000 34.36756 ? 75  LEU A CG  1 
ATOM   562  C CD1 . LEU A 1 73  ? -27.80015 12.59088  -12.14350 1.000 30.81809 ? 75  LEU A CD1 1 
ATOM   563  C CD2 . LEU A 1 73  ? -28.80735 12.52502  -9.83180  1.000 33.95952 ? 75  LEU A CD2 1 
ATOM   564  N N   . ARG A 1 74  ? -33.51193 12.65798  -11.87104 1.000 34.92505 ? 76  ARG A N   1 
ATOM   565  C CA  . ARG A 1 74  ? -34.71974 12.73774  -12.68233 1.000 30.97178 ? 76  ARG A CA  1 
ATOM   566  C C   . ARG A 1 74  ? -34.39507 13.38486  -14.02318 1.000 31.35258 ? 76  ARG A C   1 
ATOM   567  O O   . ARG A 1 74  ? -33.94015 14.53558  -14.06722 1.000 34.09317 ? 76  ARG A O   1 
ATOM   568  C CB  . ARG A 1 74  ? -35.80385 13.53659  -11.95475 1.000 36.14649 ? 76  ARG A CB  1 
ATOM   569  N N   . VAL A 1 75  ? -34.63597 12.65830  -15.11310 1.000 31.52066 ? 77  VAL A N   1 
ATOM   570  C CA  . VAL A 1 75  ? -34.45088 13.21628  -16.44936 1.000 31.92540 ? 77  VAL A CA  1 
ATOM   571  C C   . VAL A 1 75  ? -35.65306 14.08178  -16.79939 1.000 33.99737 ? 77  VAL A C   1 
ATOM   572  O O   . VAL A 1 75  ? -36.80311 13.64806  -16.67324 1.000 30.95067 ? 77  VAL A O   1 
ATOM   573  C CB  . VAL A 1 75  ? -34.25005 12.10310  -17.49526 1.000 36.99414 ? 77  VAL A CB  1 
ATOM   574  N N   . ILE A 1 76  ? -35.38876 15.30062  -17.26469 1.000 31.69111 ? 78  ILE A N   1 
ATOM   575  C CA  . ILE A 1 76  ? -36.43521 16.24287  -17.64017 1.000 36.66888 ? 78  ILE A CA  1 
ATOM   576  C C   . ILE A 1 76  ? -36.34727 16.66068  -19.09883 1.000 38.35152 ? 78  ILE A C   1 
ATOM   577  O O   . ILE A 1 76  ? -37.13223 17.50677  -19.53889 1.000 34.17271 ? 78  ILE A O   1 
ATOM   578  C CB  . ILE A 1 76  ? -36.41193 17.47948  -16.71997 1.000 35.59654 ? 78  ILE A CB  1 
ATOM   579  C CG1 . ILE A 1 76  ? -35.09286 18.23851  -16.88988 1.000 37.03825 ? 78  ILE A CG1 1 
ATOM   580  C CG2 . ILE A 1 76  ? -36.56762 17.03446  -15.27597 1.000 35.26216 ? 78  ILE A CG2 1 
ATOM   581  C CD1 . ILE A 1 76  ? -34.98801 19.48452  -16.05513 1.000 36.33526 ? 78  ILE A CD1 1 
ATOM   582  N N   . GLY A 1 77  ? -35.40270 16.11051  -19.85647 1.000 29.67371 ? 79  GLY A N   1 
ATOM   583  C CA  . GLY A 1 77  ? -35.36276 16.32511  -21.28567 1.000 32.95772 ? 79  GLY A CA  1 
ATOM   584  C C   . GLY A 1 77  ? -34.34922 15.39341  -21.90616 1.000 35.36930 ? 79  GLY A C   1 
ATOM   585  O O   . GLY A 1 77  ? -33.49098 14.83192  -21.21793 1.000 31.65851 ? 79  GLY A O   1 
ATOM   586  N N   . HIS A 1 78  ? -34.46589 15.21967  -23.21914 1.000 33.93015 ? 80  HIS A N   1 
ATOM   587  C CA  . HIS A 1 78  ? -33.54453 14.34224  -23.92112 1.000 29.23473 ? 80  HIS A CA  1 
ATOM   588  C C   . HIS A 1 78  ? -33.44349 14.78202  -25.37065 1.000 36.99172 ? 80  HIS A C   1 
ATOM   589  O O   . HIS A 1 78  ? -34.40097 15.30081  -25.95305 1.000 33.93319 ? 80  HIS A O   1 
ATOM   590  C CB  . HIS A 1 78  ? -33.98006 12.87409  -23.82570 1.000 29.56916 ? 80  HIS A CB  1 
ATOM   591  C CG  . HIS A 1 78  ? -35.32731 12.60526  -24.41661 1.000 34.92621 ? 80  HIS A CG  1 
ATOM   592  N ND1 . HIS A 1 78  ? -36.48177 12.58897  -23.66297 1.000 35.56997 ? 80  HIS A ND1 1 
ATOM   593  C CD2 . HIS A 1 78  ? -35.70559 12.34279  -25.68926 1.000 34.37691 ? 80  HIS A CD2 1 
ATOM   594  C CE1 . HIS A 1 78  ? -37.51524 12.32606  -24.44599 1.000 34.65217 ? 80  HIS A CE1 1 
ATOM   595  N NE2 . HIS A 1 78  ? -37.07186 12.17341  -25.68151 1.000 35.55763 ? 80  HIS A NE2 1 
ATOM   596  N N   . SER A 1 79  ? -32.26384 14.58055  -25.94173 1.000 33.78924 ? 81  SER A N   1 
ATOM   597  C CA  . SER A 1 79  ? -32.02341 14.89643  -27.33895 1.000 33.23055 ? 81  SER A CA  1 
ATOM   598  C C   . SER A 1 79  ? -30.78083 14.14324  -27.77228 1.000 33.69047 ? 81  SER A C   1 
ATOM   599  O O   . SER A 1 79  ? -30.04737 13.58716  -26.95185 1.000 27.05102 ? 81  SER A O   1 
ATOM   600  C CB  . SER A 1 79  ? -31.84830 16.39379  -27.56902 1.000 31.99311 ? 81  SER A CB  1 
ATOM   601  O OG  . SER A 1 79  ? -30.65120 16.84156  -26.97501 1.000 36.05893 ? 81  SER A OG  1 
ATOM   602  N N   . MET A 1 80  ? -30.55474 14.15055  -29.07767 1.000 31.38330 ? 82  MET A N   1 
ATOM   603  C CA  . MET A 1 80  ? -29.47303 13.42212  -29.71658 1.000 31.51370 ? 82  MET A CA  1 
ATOM   604  C C   . MET A 1 80  ? -28.61256 14.42268  -30.46487 1.000 31.81856 ? 82  MET A C   1 
ATOM   605  O O   . MET A 1 80  ? -29.13723 15.23918  -31.22647 1.000 30.16777 ? 82  MET A O   1 
ATOM   606  C CB  . MET A 1 80  ? -30.06404 12.38057  -30.66149 1.000 36.45645 ? 82  MET A CB  1 
ATOM   607  C CG  . MET A 1 80  ? -29.11048 11.51097  -31.39732 1.000 35.44543 ? 82  MET A CG  1 
ATOM   608  S SD  . MET A 1 80  ? -30.02606 10.08688  -32.03744 1.000 32.30315 ? 82  MET A SD  1 
ATOM   609  C CE  . MET A 1 80  ? -30.97767 10.80031  -33.38132 1.000 34.89486 ? 82  MET A CE  1 
ATOM   610  N N   . GLN A 1 81  ? -27.30153 14.37855  -30.23346 1.000 26.56562 ? 83  GLN A N   1 
ATOM   611  C CA  . GLN A 1 81  ? -26.34621 15.14568  -31.02145 1.000 25.31145 ? 83  GLN A CA  1 
ATOM   612  C C   . GLN A 1 81  ? -25.39914 14.14099  -31.65836 1.000 29.28839 ? 83  GLN A C   1 
ATOM   613  O O   . GLN A 1 81  ? -24.57361 13.53444  -30.96206 1.000 25.92143 ? 83  GLN A O   1 
ATOM   614  C CB  . GLN A 1 81  ? -25.59204 16.16181  -30.17272 1.000 29.58641 ? 83  GLN A CB  1 
ATOM   615  C CG  . GLN A 1 81  ? -24.57173 16.97733  -30.96859 1.000 30.48891 ? 83  GLN A CG  1 
ATOM   616  C CD  . GLN A 1 81  ? -23.84964 17.99618  -30.10653 1.000 31.25396 ? 83  GLN A CD  1 
ATOM   617  O OE1 . GLN A 1 81  ? -23.98197 17.99136  -28.88417 1.000 30.89121 ? 83  GLN A OE1 1 
ATOM   618  N NE2 . GLN A 1 81  ? -23.10091 18.89077  -30.74227 1.000 31.06481 ? 83  GLN A NE2 1 
ATOM   619  N N   . ASN A 1 82  ? -25.55082 13.94203  -32.96979 1.000 27.13865 ? 84  ASN A N   1 
ATOM   620  C CA  . ASN A 1 82  ? -24.81149 12.91029  -33.68450 1.000 28.04017 ? 84  ASN A CA  1 
ATOM   621  C C   . ASN A 1 82  ? -25.00328 11.58020  -32.96341 1.000 30.85262 ? 84  ASN A C   1 
ATOM   622  O O   . ASN A 1 82  ? -26.14487 11.16546  -32.77765 1.000 26.54628 ? 84  ASN A O   1 
ATOM   623  C CB  . ASN A 1 82  ? -23.34326 13.32170  -33.82176 1.000 27.03964 ? 84  ASN A CB  1 
ATOM   624  C CG  . ASN A 1 82  ? -23.19292 14.61922  -34.57845 1.000 29.80818 ? 84  ASN A CG  1 
ATOM   625  O OD1 . ASN A 1 82  ? -23.54537 14.69715  -35.76070 1.000 34.39175 ? 84  ASN A OD1 1 
ATOM   626  N ND2 . ASN A 1 82  ? -22.71645 15.65416  -33.90564 1.000 29.46102 ? 84  ASN A ND2 1 
ATOM   627  N N   . CYS A 1 83  ? -23.93361 10.91482  -32.51295 1.000 23.74726 ? 85  CYS A N   1 
ATOM   628  C CA  . CYS A 1 83  ? -24.08603 9.60445   -31.89404 1.000 26.51941 ? 85  CYS A CA  1 
ATOM   629  C C   . CYS A 1 83  ? -24.11789 9.64627   -30.36704 1.000 24.86607 ? 85  CYS A C   1 
ATOM   630  O O   . CYS A 1 83  ? -24.01801 8.59362   -29.73259 1.000 24.44187 ? 85  CYS A O   1 
ATOM   631  C CB  . CYS A 1 83  ? -22.97581 8.66169   -32.37082 1.000 25.96049 ? 85  CYS A CB  1 
ATOM   632  S SG  . CYS A 1 83  ? -22.98738 8.48304   -34.16855 1.000 26.99317 ? 85  CYS A SG  1 
ATOM   633  N N   . VAL A 1 84  ? -24.26918 10.81997  -29.75814 1.000 23.52897 ? 86  VAL A N   1 
ATOM   634  C CA  . VAL A 1 84  ? -24.31278 10.93326  -28.30640 1.000 23.54711 ? 86  VAL A CA  1 
ATOM   635  C C   . VAL A 1 84  ? -25.70146 11.38662  -27.87319 1.000 28.47515 ? 86  VAL A C   1 
ATOM   636  O O   . VAL A 1 84  ? -26.29757 12.29456  -28.47464 1.000 27.23542 ? 86  VAL A O   1 
ATOM   637  C CB  . VAL A 1 84  ? -23.20250 11.86846  -27.78753 1.000 26.33479 ? 86  VAL A CB  1 
ATOM   638  C CG1 . VAL A 1 84  ? -23.54680 12.44682  -26.43084 1.000 26.36443 ? 86  VAL A CG1 1 
ATOM   639  C CG2 . VAL A 1 84  ? -21.91923 11.05952  -27.67484 1.000 23.70006 ? 86  VAL A CG2 1 
ATOM   640  N N   . LEU A 1 85  ? -26.23755 10.70190  -26.87155 1.000 24.17706 ? 87  LEU A N   1 
ATOM   641  C CA  . LEU A 1 85  ? -27.48707 11.09073  -26.24446 1.000 26.60038 ? 87  LEU A CA  1 
ATOM   642  C C   . LEU A 1 85  ? -27.19126 12.08065  -25.12055 1.000 29.61358 ? 87  LEU A C   1 
ATOM   643  O O   . LEU A 1 85  ? -26.20126 11.93407  -24.39236 1.000 26.95404 ? 87  LEU A O   1 
ATOM   644  C CB  . LEU A 1 85  ? -28.19523 9.84367   -25.71824 1.000 24.48878 ? 87  LEU A CB  1 
ATOM   645  C CG  . LEU A 1 85  ? -29.49659 10.00516  -24.93689 1.000 33.84127 ? 87  LEU A CG  1 
ATOM   646  C CD1 . LEU A 1 85  ? -30.60375 10.58359  -25.81379 1.000 31.65502 ? 87  LEU A CD1 1 
ATOM   647  C CD2 . LEU A 1 85  ? -29.90025 8.65473   -24.34409 1.000 33.22542 ? 87  LEU A CD2 1 
ATOM   648  N N   . LYS A 1 86  ? -28.01968 13.11979  -25.01542 1.000 27.82399 ? 88  LYS A N   1 
ATOM   649  C CA  . LYS A 1 86  ? -27.90173 14.12117  -23.95824 1.000 27.55754 ? 88  LYS A CA  1 
ATOM   650  C C   . LYS A 1 86  ? -29.19429 14.13815  -23.15324 1.000 28.57315 ? 88  LYS A C   1 
ATOM   651  O O   . LYS A 1 86  ? -30.25309 14.51656  -23.67182 1.000 28.33945 ? 88  LYS A O   1 
ATOM   652  C CB  . LYS A 1 86  ? -27.58641 15.49686  -24.53403 1.000 27.51697 ? 88  LYS A CB  1 
ATOM   653  C CG  . LYS A 1 86  ? -26.32853 15.48658  -25.41022 1.000 30.01704 ? 88  LYS A CG  1 
ATOM   654  C CD  . LYS A 1 86  ? -25.85870 16.88742  -25.74992 1.000 30.91236 ? 88  LYS A CD  1 
ATOM   655  C CE  . LYS A 1 86  ? -26.80816 17.58627  -26.69304 1.000 36.61579 ? 88  LYS A CE  1 
ATOM   656  N NZ  . LYS A 1 86  ? -26.23197 18.87108  -27.17219 1.000 37.78578 ? 88  LYS A NZ  1 
ATOM   657  N N   . LEU A 1 87  ? -29.09653 13.71886  -21.89779 1.000 27.86899 ? 89  LEU A N   1 
ATOM   658  C CA  . LEU A 1 87  ? -30.20760 13.71546  -20.95311 1.000 26.13279 ? 89  LEU A CA  1 
ATOM   659  C C   . LEU A 1 87  ? -30.07378 14.93460  -20.04995 1.000 31.31342 ? 89  LEU A C   1 
ATOM   660  O O   . LEU A 1 87  ? -29.12084 15.03686  -19.26891 1.000 28.93925 ? 89  LEU A O   1 
ATOM   661  C CB  . LEU A 1 87  ? -30.20436 12.42155  -20.14307 1.000 25.88765 ? 89  LEU A CB  1 
ATOM   662  C CG  . LEU A 1 87  ? -30.20121 11.15055  -21.00229 1.000 29.64066 ? 89  LEU A CG  1 
ATOM   663  C CD1 . LEU A 1 87  ? -30.15310 9.91777   -20.13907 1.000 24.71905 ? 89  LEU A CD1 1 
ATOM   664  C CD2 . LEU A 1 87  ? -31.45927 11.11564  -21.89330 1.000 28.62586 ? 89  LEU A CD2 1 
ATOM   665  N N   . LYS A 1 88  ? -31.00295 15.87770  -20.17603 1.000 28.35726 ? 90  LYS A N   1 
ATOM   666  C CA  . LYS A 1 88  ? -31.08275 16.95657  -19.19873 1.000 32.61754 ? 90  LYS A CA  1 
ATOM   667  C C   . LYS A 1 88  ? -31.66829 16.40562  -17.90684 1.000 31.87912 ? 90  LYS A C   1 
ATOM   668  O O   . LYS A 1 88  ? -32.66112 15.66668  -17.92883 1.000 31.98178 ? 90  LYS A O   1 
ATOM   669  C CB  . LYS A 1 88  ? -31.93729 18.10893  -19.72327 1.000 35.67131 ? 90  LYS A CB  1 
ATOM   670  C CG  . LYS A 1 88  ? -31.49617 19.47122  -19.20714 1.000 38.38962 ? 90  LYS A CG  1 
ATOM   671  C CD  . LYS A 1 88  ? -32.55633 20.52947  -19.45190 1.000 43.52315 ? 90  LYS A CD  1 
ATOM   672  C CE  . LYS A 1 88  ? -31.98792 21.94464  -19.34022 1.000 50.68086 ? 90  LYS A CE  1 
ATOM   673  N NZ  . LYS A 1 88  ? -33.01588 22.98285  -19.69061 1.000 55.19439 ? 90  LYS A NZ  1 
ATOM   674  N N   . VAL A 1 89  ? -31.05511 16.73891  -16.77520 1.000 28.57282 ? 91  VAL A N   1 
ATOM   675  C CA  . VAL A 1 89  ? -31.52543 16.20578  -15.50337 1.000 30.03514 ? 91  VAL A CA  1 
ATOM   676  C C   . VAL A 1 89  ? -31.89720 17.34218  -14.55544 1.000 35.16651 ? 91  VAL A C   1 
ATOM   677  O O   . VAL A 1 89  ? -31.64042 18.52068  -14.81234 1.000 31.12923 ? 91  VAL A O   1 
ATOM   678  C CB  . VAL A 1 89  ? -30.51049 15.25927  -14.82719 1.000 30.98786 ? 91  VAL A CB  1 
ATOM   679  C CG1 . VAL A 1 89  ? -30.41593 13.91537  -15.58215 1.000 29.51059 ? 91  VAL A CG1 1 
ATOM   680  C CG2 . VAL A 1 89  ? -29.14126 15.93971  -14.69832 1.000 32.74747 ? 91  VAL A CG2 1 
ATOM   681  N N   . ASP A 1 90  ? -32.50434 16.91846  -13.43425 1.000 34.30975 ? 92  ASP A N   1 
ATOM   682  C CA  . ASP A 1 90  ? -33.03335 17.73747  -12.34295 1.000 43.15823 ? 92  ASP A CA  1 
ATOM   683  C C   . ASP A 1 90  ? -32.00914 18.66915  -11.72675 1.000 42.75279 ? 92  ASP A C   1 
ATOM   684  O O   . ASP A 1 90  ? -32.35988 19.74260  -11.22019 1.000 36.81867 ? 92  ASP A O   1 
ATOM   685  C CB  . ASP A 1 90  ? -33.51109 16.78884  -11.23047 1.000 40.28966 ? 92  ASP A CB  1 
ATOM   686  C CG  . ASP A 1 90  ? -34.85516 17.15488  -10.68072 1.000 50.49113 ? 92  ASP A CG  1 
ATOM   687  O OD1 . ASP A 1 90  ? -35.54879 17.96248  -11.32651 1.000 59.21333 ? 92  ASP A OD1 1 
ATOM   688  O OD2 . ASP A 1 90  ? -35.22385 16.62034  -9.60867  1.000 54.15440 ? 92  ASP A OD2 1 
ATOM   689  N N   . THR A 1 91  ? -30.75587 18.24117  -11.69927 1.000 36.81678 ? 93  THR A N   1 
ATOM   690  C CA  . THR A 1 91  ? -29.78748 18.69278  -10.71834 1.000 35.86597 ? 93  THR A CA  1 
ATOM   691  C C   . THR A 1 91  ? -28.46072 18.86623  -11.43052 1.000 33.14173 ? 93  THR A C   1 
ATOM   692  O O   . THR A 1 91  ? -28.05649 17.98327  -12.19236 1.000 29.65928 ? 93  THR A O   1 
ATOM   693  C CB  . THR A 1 91  ? -29.65455 17.65885  -9.59247  1.000 38.52227 ? 93  THR A CB  1 
ATOM   694  O OG1 . THR A 1 91  ? -30.94520 17.38954  -9.02728  1.000 40.53045 ? 93  THR A OG1 1 
ATOM   695  C CG2 . THR A 1 91  ? -28.69178 18.13225  -8.50181  1.000 39.94497 ? 93  THR A CG2 1 
ATOM   696  N N   . ALA A 1 92  ? -27.80626 20.00128  -11.20819 1.000 30.43516 ? 94  ALA A N   1 
ATOM   697  C CA  . ALA A 1 92  ? -26.45757 20.18333  -11.72627 1.000 34.66760 ? 94  ALA A CA  1 
ATOM   698  C C   . ALA A 1 92  ? -25.46999 19.40796  -10.86079 1.000 31.27755 ? 94  ALA A C   1 
ATOM   699  O O   . ALA A 1 92  ? -25.58026 19.38514  -9.63266  1.000 30.34332 ? 94  ALA A O   1 
ATOM   700  C CB  . ALA A 1 92  ? -26.08531 21.66955  -11.77151 1.000 32.71772 ? 94  ALA A CB  1 
ATOM   701  N N   . ASN A 1 93  ? -24.51549 18.74433  -11.50270 1.000 29.33127 ? 95  ASN A N   1 
ATOM   702  C CA  . ASN A 1 93  ? -23.58782 17.92204  -10.74199 1.000 30.44822 ? 95  ASN A CA  1 
ATOM   703  C C   . ASN A 1 93  ? -22.74311 18.82280  -9.83505  1.000 28.89342 ? 95  ASN A C   1 
ATOM   704  O O   . ASN A 1 93  ? -21.99263 19.67156  -10.34518 1.000 29.91187 ? 95  ASN A O   1 
ATOM   705  C CB  . ASN A 1 93  ? -22.71183 17.11276  -11.70814 1.000 28.92538 ? 95  ASN A CB  1 
ATOM   706  C CG  . ASN A 1 93  ? -21.74397 16.17484  -10.99525 1.000 28.86682 ? 95  ASN A CG  1 
ATOM   707  O OD1 . ASN A 1 93  ? -21.74950 16.04988  -9.76574  1.000 28.20539 ? 95  ASN A OD1 1 
ATOM   708  N ND2 . ASN A 1 93  ? -20.88836 15.51600  -11.77837 1.000 26.32208 ? 95  ASN A ND2 1 
ATOM   709  N N   . PRO A 1 94  ? -22.85124 18.70313  -8.50538  1.000 26.28402 ? 96  PRO A N   1 
ATOM   710  C CA  . PRO A 1 94  ? -22.05096 19.57478  -7.63232  1.000 30.55303 ? 96  PRO A CA  1 
ATOM   711  C C   . PRO A 1 94  ? -20.55947 19.33428  -7.76317  1.000 33.22547 ? 96  PRO A C   1 
ATOM   712  O O   . PRO A 1 94  ? -19.76635 20.20317  -7.37573  1.000 30.11659 ? 96  PRO A O   1 
ATOM   713  C CB  . PRO A 1 94  ? -22.55389 19.22598  -6.22623  1.000 34.63615 ? 96  PRO A CB  1 
ATOM   714  C CG  . PRO A 1 94  ? -23.05781 17.82039  -6.35428  1.000 37.25144 ? 96  PRO A CG  1 
ATOM   715  C CD  . PRO A 1 94  ? -23.65895 17.74001  -7.73778  1.000 30.87062 ? 96  PRO A CD  1 
ATOM   716  N N   . LYS A 1 95  ? -20.15353 18.19214  -8.31061  1.000 31.09617 ? 97  LYS A N   1 
ATOM   717  C CA  . LYS A 1 95  ? -18.74491 17.86787  -8.49148  1.000 29.29735 ? 97  LYS A CA  1 
ATOM   718  C C   . LYS A 1 95  ? -18.25726 18.12798  -9.91065  1.000 31.58342 ? 97  LYS A C   1 
ATOM   719  O O   . LYS A 1 95  ? -17.17725 17.65415  -10.27132 1.000 30.60796 ? 97  LYS A O   1 
ATOM   720  C CB  . LYS A 1 95  ? -18.48548 16.40769  -8.12259  1.000 27.57579 ? 97  LYS A CB  1 
ATOM   721  C CG  . LYS A 1 95  ? -18.74474 16.06348  -6.66980  1.000 35.74934 ? 97  LYS A CG  1 
ATOM   722  C CD  . LYS A 1 95  ? -18.74494 14.55212  -6.48542  1.000 38.06095 ? 97  LYS A CD  1 
ATOM   723  C CE  . LYS A 1 95  ? -18.42880 14.14347  -5.05768  1.000 48.27274 ? 97  LYS A CE  1 
ATOM   724  N NZ  . LYS A 1 95  ? -18.67471 12.67949  -4.86875  1.000 50.27509 ? 97  LYS A NZ  1 
ATOM   725  N N   . THR A 1 96  ? -19.02733 18.85398  -10.72423 1.000 30.00090 ? 98  THR A N   1 
ATOM   726  C CA  . THR A 1 96  ? -18.57124 19.22450  -12.06143 1.000 28.62367 ? 98  THR A CA  1 
ATOM   727  C C   . THR A 1 96  ? -17.23962 19.96322  -11.96918 1.000 30.40702 ? 98  THR A C   1 
ATOM   728  O O   . THR A 1 96  ? -17.15621 20.97985  -11.27526 1.000 27.80180 ? 98  THR A O   1 
ATOM   729  C CB  . THR A 1 96  ? -19.59580 20.11583  -12.76798 1.000 29.48511 ? 98  THR A CB  1 
ATOM   730  O OG1 . THR A 1 96  ? -20.87195 19.46236  -12.78578 1.000 30.48231 ? 98  THR A OG1 1 
ATOM   731  C CG2 . THR A 1 96  ? -19.15180 20.40665  -14.19415 1.000 27.51575 ? 98  THR A CG2 1 
ATOM   732  N N   . PRO A 1 97  ? -16.18812 19.49496  -12.62454 1.000 28.77138 ? 99  PRO A N   1 
ATOM   733  C CA  . PRO A 1 97  ? -14.94130 20.26136  -12.65262 1.000 28.36812 ? 99  PRO A CA  1 
ATOM   734  C C   . PRO A 1 97  ? -15.00387 21.32476  -13.74153 1.000 30.15772 ? 99  PRO A C   1 
ATOM   735  O O   . PRO A 1 97  ? -15.93527 21.38032  -14.54349 1.000 31.37129 ? 99  PRO A O   1 
ATOM   736  C CB  . PRO A 1 97  ? -13.89807 19.19355  -12.97225 1.000 26.54515 ? 99  PRO A CB  1 
ATOM   737  C CG  . PRO A 1 97  ? -14.64551 18.26587  -13.93098 1.000 25.83936 ? 99  PRO A CG  1 
ATOM   738  C CD  . PRO A 1 97  ? -16.08753 18.24551  -13.40355 1.000 27.41143 ? 99  PRO A CD  1 
ATOM   739  N N   . LYS A 1 98  ? -13.98785 22.18166  -13.75768 1.000 28.69325 ? 100 LYS A N   1 
ATOM   740  C CA  . LYS A 1 98  ? -13.76038 23.00123  -14.93732 1.000 32.57114 ? 100 LYS A CA  1 
ATOM   741  C C   . LYS A 1 98  ? -13.49121 22.07473  -16.11740 1.000 31.66495 ? 100 LYS A C   1 
ATOM   742  O O   . LYS A 1 98  ? -12.70073 21.13606  -15.99939 1.000 28.91741 ? 100 LYS A O   1 
ATOM   743  C CB  . LYS A 1 98  ? -12.58243 23.95271  -14.70634 1.000 31.07650 ? 100 LYS A CB  1 
ATOM   744  N N   . TYR A 1 99  ? -14.17939 22.29550  -17.24239 1.000 27.66130 ? 101 TYR A N   1 
ATOM   745  C CA  . TYR A 1 99  ? -14.06200 21.33887  -18.33755 1.000 28.64774 ? 101 TYR A CA  1 
ATOM   746  C C   . TYR A 1 99  ? -14.29191 22.00412  -19.68502 1.000 26.72441 ? 101 TYR A C   1 
ATOM   747  O O   . TYR A 1 99  ? -14.85559 23.09342  -19.77641 1.000 27.80229 ? 101 TYR A O   1 
ATOM   748  C CB  . TYR A 1 99  ? -15.03529 20.16061  -18.16622 1.000 25.43373 ? 101 TYR A CB  1 
ATOM   749  C CG  . TYR A 1 99  ? -16.47920 20.49610  -18.46987 1.000 30.08228 ? 101 TYR A CG  1 
ATOM   750  C CD1 . TYR A 1 99  ? -17.29039 21.08840  -17.50774 1.000 28.56463 ? 101 TYR A CD1 1 
ATOM   751  C CD2 . TYR A 1 99  ? -17.03257 20.20322  -19.70881 1.000 29.43135 ? 101 TYR A CD2 1 
ATOM   752  C CE1 . TYR A 1 99  ? -18.62913 21.39244  -17.77698 1.000 30.02999 ? 101 TYR A CE1 1 
ATOM   753  C CE2 . TYR A 1 99  ? -18.36199 20.50181  -19.99004 1.000 29.86025 ? 101 TYR A CE2 1 
ATOM   754  C CZ  . TYR A 1 99  ? -19.15294 21.09274  -19.01712 1.000 31.11733 ? 101 TYR A CZ  1 
ATOM   755  O OH  . TYR A 1 99  ? -20.46850 21.39238  -19.29576 1.000 34.60942 ? 101 TYR A OH  1 
ATOM   756  N N   . LYS A 1 100 ? -13.81949 21.32216  -20.73060 1.000 28.76079 ? 102 LYS A N   1 
ATOM   757  C CA  . LYS A 1 100 ? -14.07560 21.64705  -22.12768 1.000 30.14204 ? 102 LYS A CA  1 
ATOM   758  C C   . LYS A 1 100 ? -14.24777 20.34427  -22.89906 1.000 28.57486 ? 102 LYS A C   1 
ATOM   759  O O   . LYS A 1 100 ? -13.83291 19.27369  -22.45182 1.000 26.95631 ? 102 LYS A O   1 
ATOM   760  C CB  . LYS A 1 100 ? -12.92209 22.42713  -22.79175 1.000 34.86844 ? 102 LYS A CB  1 
ATOM   761  C CG  . LYS A 1 100 ? -12.09817 23.30793  -21.88550 1.000 44.02602 ? 102 LYS A CG  1 
ATOM   762  C CD  . LYS A 1 100 ? -11.13880 24.19969  -22.68573 1.000 41.28361 ? 102 LYS A CD  1 
ATOM   763  C CE  . LYS A 1 100 ? -9.78683  23.54969  -22.88948 1.000 45.15276 ? 102 LYS A CE  1 
ATOM   764  N NZ  . LYS A 1 100 ? -8.91134  23.66891  -21.68071 1.000 54.37572 ? 102 LYS A NZ  1 
ATOM   765  N N   . PHE A 1 101 ? -14.83331 20.45247  -24.08705 1.000 25.02928 ? 103 PHE A N   1 
ATOM   766  C CA  . PHE A 1 101 ? -14.88467 19.37027  -25.05611 1.000 24.90799 ? 103 PHE A CA  1 
ATOM   767  C C   . PHE A 1 101 ? -13.89476 19.69281  -26.16287 1.000 27.85345 ? 103 PHE A C   1 
ATOM   768  O O   . PHE A 1 101 ? -13.86837 20.82061  -26.65737 1.000 30.73070 ? 103 PHE A O   1 
ATOM   769  C CB  . PHE A 1 101 ? -16.29763 19.19838  -25.64476 1.000 21.02758 ? 103 PHE A CB  1 
ATOM   770  C CG  . PHE A 1 101 ? -17.30964 18.68976  -24.65898 1.000 24.05187 ? 103 PHE A CG  1 
ATOM   771  C CD1 . PHE A 1 101 ? -16.91129 18.21131  -23.41895 1.000 26.05957 ? 103 PHE A CD1 1 
ATOM   772  C CD2 . PHE A 1 101 ? -18.66791 18.69197  -24.96716 1.000 24.84614 ? 103 PHE A CD2 1 
ATOM   773  C CE1 . PHE A 1 101 ? -17.83391 17.73528  -22.51220 1.000 26.85620 ? 103 PHE A CE1 1 
ATOM   774  C CE2 . PHE A 1 101 ? -19.59753 18.21032  -24.06284 1.000 26.20297 ? 103 PHE A CE2 1 
ATOM   775  C CZ  . PHE A 1 101 ? -19.19036 17.73977  -22.83859 1.000 27.45210 ? 103 PHE A CZ  1 
ATOM   776  N N   . VAL A 1 102 ? -13.07837 18.71240  -26.54195 1.000 26.93246 ? 104 VAL A N   1 
ATOM   777  C CA  . VAL A 1 102 ? -12.10621 18.88176  -27.61229 1.000 28.95143 ? 104 VAL A CA  1 
ATOM   778  C C   . VAL A 1 102 ? -12.13244 17.63990  -28.49476 1.000 29.71480 ? 104 VAL A C   1 
ATOM   779  O O   . VAL A 1 102 ? -12.43591 16.53458  -28.03701 1.000 31.25007 ? 104 VAL A O   1 
ATOM   780  C CB  . VAL A 1 102 ? -10.68243 19.13252  -27.04613 1.000 31.99193 ? 104 VAL A CB  1 
ATOM   781  C CG1 . VAL A 1 102 ? -10.64416 20.43926  -26.26767 1.000 31.66772 ? 104 VAL A CG1 1 
ATOM   782  C CG2 . VAL A 1 102 ? -10.28360 17.99290  -26.12949 1.000 33.30636 ? 104 VAL A CG2 1 
ATOM   783  N N   . ARG A 1 103 ? -11.82644 17.81744  -29.77423 1.000 24.31400 ? 105 ARG A N   1 
ATOM   784  C CA  . ARG A 1 103 ? -11.64843 16.68521  -30.66741 1.000 24.43948 ? 105 ARG A CA  1 
ATOM   785  C C   . ARG A 1 103 ? -10.15459 16.49652  -30.88555 1.000 27.33364 ? 105 ARG A C   1 
ATOM   786  O O   . ARG A 1 103 ? -9.44459  17.46190  -31.17984 1.000 26.16076 ? 105 ARG A O   1 
ATOM   787  C CB  . ARG A 1 103 ? -12.36298 16.89269  -32.00320 1.000 29.77546 ? 105 ARG A CB  1 
ATOM   788  C CG  . ARG A 1 103 ? -12.27309 15.69249  -32.93666 1.000 30.42989 ? 105 ARG A CG  1 
ATOM   789  C CD  . ARG A 1 103 ? -13.20883 15.80789  -34.12821 1.000 31.61043 ? 105 ARG A CD  1 
ATOM   790  N NE  . ARG A 1 103 ? -13.07169 14.66418  -35.02416 1.000 28.70448 ? 105 ARG A NE  1 
ATOM   791  C CZ  . ARG A 1 103 ? -13.74870 13.52531  -34.89882 1.000 29.32085 ? 105 ARG A CZ  1 
ATOM   792  N NH1 . ARG A 1 103 ? -14.62271 13.36888  -33.90865 1.000 27.62383 ? 105 ARG A NH1 1 
ATOM   793  N NH2 . ARG A 1 103 ? -13.54449 12.53559  -35.75489 1.000 33.23943 ? 105 ARG A NH2 1 
ATOM   794  N N   . ILE A 1 104 ? -9.67746  15.26566  -30.73292 1.000 26.38699 ? 106 ILE A N   1 
ATOM   795  C CA  . ILE A 1 104 ? -8.24243  15.03974  -30.86909 1.000 32.48914 ? 106 ILE A CA  1 
ATOM   796  C C   . ILE A 1 104 ? -7.93954  14.39608  -32.21023 1.000 31.37005 ? 106 ILE A C   1 
ATOM   797  O O   . ILE A 1 104 ? -8.84240  14.09549  -32.99641 1.000 30.41725 ? 106 ILE A O   1 
ATOM   798  C CB  . ILE A 1 104 ? -7.68664  14.18344  -29.72244 1.000 31.57124 ? 106 ILE A CB  1 
ATOM   799  C CG1 . ILE A 1 104 ? -8.51507  12.91518  -29.58514 1.000 31.60937 ? 106 ILE A CG1 1 
ATOM   800  C CG2 . ILE A 1 104 ? -7.62659  14.99211  -28.43378 1.000 31.97264 ? 106 ILE A CG2 1 
ATOM   801  C CD1 . ILE A 1 104 ? -7.70738  11.75113  -29.13085 1.000 35.49532 ? 106 ILE A CD1 1 
ATOM   802  N N   . GLN A 1 105 ? -6.66048  14.19976  -32.48108 1.000 31.11034 ? 107 GLN A N   1 
ATOM   803  C CA  . GLN A 1 105 ? -6.20011  13.61752  -33.72069 1.000 34.84585 ? 107 GLN A CA  1 
ATOM   804  C C   . GLN A 1 105 ? -5.39450  12.36729  -33.42646 1.000 31.78392 ? 107 GLN A C   1 
ATOM   805  O O   . GLN A 1 105 ? -4.82101  12.24189  -32.33879 1.000 25.57409 ? 107 GLN A O   1 
ATOM   806  C CB  . GLN A 1 105 ? -5.33923  14.61286  -34.50556 1.000 35.63019 ? 107 GLN A CB  1 
ATOM   807  C CG  . GLN A 1 105 ? -6.07669  15.90765  -34.77336 1.000 41.42121 ? 107 GLN A CG  1 
ATOM   808  C CD  . GLN A 1 105 ? -6.84726  15.89407  -36.06835 1.000 46.44225 ? 107 GLN A CD  1 
ATOM   809  O OE1 . GLN A 1 105 ? -8.03603  15.57034  -36.09269 1.000 51.79143 ? 107 GLN A OE1 1 
ATOM   810  N NE2 . GLN A 1 105 ? -6.17970  16.26520  -37.15776 1.000 50.97486 ? 107 GLN A NE2 1 
ATOM   811  N N   . PRO A 1 106 ? -5.35347  11.42350  -34.36585 1.000 31.57442 ? 108 PRO A N   1 
ATOM   812  C CA  . PRO A 1 106 ? -4.50673  10.23631  -34.19834 1.000 27.59915 ? 108 PRO A CA  1 
ATOM   813  C C   . PRO A 1 106 ? -3.08744  10.62633  -33.80922 1.000 29.22741 ? 108 PRO A C   1 
ATOM   814  O O   . PRO A 1 106 ? -2.52641  11.59520  -34.32623 1.000 29.86514 ? 108 PRO A O   1 
ATOM   815  C CB  . PRO A 1 106 ? -4.54996  9.57616   -35.57837 1.000 30.66310 ? 108 PRO A CB  1 
ATOM   816  C CG  . PRO A 1 106 ? -5.83811  10.05509  -36.17864 1.000 35.00978 ? 108 PRO A CG  1 
ATOM   817  C CD  . PRO A 1 106 ? -6.05143  11.44057  -35.66843 1.000 31.43954 ? 108 PRO A CD  1 
ATOM   818  N N   . GLY A 1 107 ? -2.52136  9.88033   -32.86168 1.000 28.48269 ? 109 GLY A N   1 
ATOM   819  C CA  . GLY A 1 107 ? -1.23883  10.19453  -32.27778 1.000 26.20583 ? 109 GLY A CA  1 
ATOM   820  C C   . GLY A 1 107 ? -1.31785  10.98140  -30.98281 1.000 28.82179 ? 109 GLY A C   1 
ATOM   821  O O   . GLY A 1 107 ? -0.37162  10.93444  -30.18041 1.000 26.74334 ? 109 GLY A O   1 
ATOM   822  N N   . GLN A 1 108 ? -2.41919  11.69345  -30.74395 1.000 23.18229 ? 110 GLN A N   1 
ATOM   823  C CA  . GLN A 1 108 ? -2.50907  12.42855  -29.49631 1.000 24.24742 ? 110 GLN A CA  1 
ATOM   824  C C   . GLN A 1 108 ? -2.89796  11.47313  -28.37402 1.000 23.21362 ? 110 GLN A C   1 
ATOM   825  O O   . GLN A 1 108 ? -3.49826  10.41903  -28.60102 1.000 25.62384 ? 110 GLN A O   1 
ATOM   826  C CB  . GLN A 1 108 ? -3.48884  13.60413  -29.63424 1.000 31.98717 ? 110 GLN A CB  1 
ATOM   827  C CG  . GLN A 1 108 ? -3.13545  14.44538  -30.89425 1.000 34.70716 ? 110 GLN A CG  1 
ATOM   828  C CD  . GLN A 1 108 ? -3.81042  15.81878  -31.01303 1.000 39.96356 ? 110 GLN A CD  1 
ATOM   829  O OE1 . GLN A 1 108 ? -4.96529  16.01970  -30.63086 1.000 34.34227 ? 110 GLN A OE1 1 
ATOM   830  N NE2 . GLN A 1 108 ? -3.06838  16.77399  -31.56294 1.000 46.02268 ? 110 GLN A NE2 1 
ATOM   831  N N   . THR A 1 109 ? -2.52960  11.84819  -27.15291 1.000 20.76742 ? 111 THR A N   1 
ATOM   832  C CA  . THR A 1 109 ? -2.64949  10.98441  -25.99572 1.000 19.76123 ? 111 THR A CA  1 
ATOM   833  C C   . THR A 1 109 ? -3.71464  11.51037  -25.04521 1.000 22.58964 ? 111 THR A C   1 
ATOM   834  O O   . THR A 1 109 ? -4.06480  12.69059  -25.06185 1.000 24.63113 ? 111 THR A O   1 
ATOM   835  C CB  . THR A 1 109 ? -1.31004  10.88114  -25.26520 1.000 24.47743 ? 111 THR A CB  1 
ATOM   836  O OG1 . THR A 1 109 ? -0.84654  12.20324  -24.97477 1.000 25.49894 ? 111 THR A OG1 1 
ATOM   837  C CG2 . THR A 1 109 ? -0.29454  10.17718  -26.16018 1.000 26.93888 ? 111 THR A CG2 1 
ATOM   838  N N   . PHE A 1 110 ? -4.19321  10.61591  -24.19234 1.000 22.63862 ? 112 PHE A N   1 
ATOM   839  C CA  . PHE A 1 110 ? -5.19902  10.94886  -23.19576 1.000 23.88233 ? 112 PHE A CA  1 
ATOM   840  C C   . PHE A 1 110 ? -5.34256  9.76486   -22.24830 1.000 23.99877 ? 112 PHE A C   1 
ATOM   841  O O   . PHE A 1 110 ? -4.87401  8.65633   -22.53412 1.000 24.84298 ? 112 PHE A O   1 
ATOM   842  C CB  . PHE A 1 110 ? -6.54448  11.30922  -23.85042 1.000 22.85616 ? 112 PHE A CB  1 
ATOM   843  C CG  . PHE A 1 110 ? -7.09407  10.24312  -24.77179 1.000 25.99788 ? 112 PHE A CG  1 
ATOM   844  C CD1 . PHE A 1 110 ? -6.73537  10.20494  -26.10535 1.000 25.72221 ? 112 PHE A CD1 1 
ATOM   845  C CD2 . PHE A 1 110 ? -8.02908  9.30660   -24.30757 1.000 22.94369 ? 112 PHE A CD2 1 
ATOM   846  C CE1 . PHE A 1 110 ? -7.26908  9.23216   -26.97102 1.000 29.82924 ? 112 PHE A CE1 1 
ATOM   847  C CE2 . PHE A 1 110 ? -8.55488  8.33383   -25.16099 1.000 24.91136 ? 112 PHE A CE2 1 
ATOM   848  C CZ  . PHE A 1 110 ? -8.17907  8.30229   -26.49357 1.000 26.81988 ? 112 PHE A CZ  1 
ATOM   849  N N   . SER A 1 111 ? -5.95998  10.02108  -21.09959 1.000 20.64392 ? 113 SER A N   1 
ATOM   850  C CA  . SER A 1 111 ? -6.27397  8.98466   -20.12566 1.000 21.49813 ? 113 SER A CA  1 
ATOM   851  C C   . SER A 1 111 ? -7.70475  8.51342   -20.33024 1.000 24.89071 ? 113 SER A C   1 
ATOM   852  O O   . SER A 1 111 ? -8.58043  9.31270   -20.67235 1.000 23.23602 ? 113 SER A O   1 
ATOM   853  C CB  . SER A 1 111 ? -6.11983  9.50052   -18.68763 1.000 22.77343 ? 113 SER A CB  1 
ATOM   854  O OG  . SER A 1 111 ? -4.76128  9.84008   -18.39807 1.000 25.61078 ? 113 SER A OG  1 
ATOM   855  N N   . VAL A 1 112 ? -7.94000  7.22485   -20.09876 1.000 22.06375 ? 114 VAL A N   1 
ATOM   856  C CA  . VAL A 1 112 ? -9.27888  6.64142   -20.14804 1.000 25.50500 ? 114 VAL A CA  1 
ATOM   857  C C   . VAL A 1 112 ? -9.62559  6.14930   -18.75477 1.000 23.16473 ? 114 VAL A C   1 
ATOM   858  O O   . VAL A 1 112 ? -8.85184  5.40011   -18.14678 1.000 24.10607 ? 114 VAL A O   1 
ATOM   859  C CB  . VAL A 1 112 ? -9.37211  5.48075   -21.15026 1.000 25.54344 ? 114 VAL A CB  1 
ATOM   860  C CG1 . VAL A 1 112 ? -10.74538 4.86348   -21.05533 1.000 27.14414 ? 114 VAL A CG1 1 
ATOM   861  C CG2 . VAL A 1 112 ? -9.08612  5.95428   -22.56177 1.000 27.18362 ? 114 VAL A CG2 1 
ATOM   862  N N   . LEU A 1 113 ? -10.76365 6.58992   -18.23479 1.000 21.52076 ? 115 LEU A N   1 
ATOM   863  C CA  . LEU A 1 113 ? -11.27766 6.03625   -16.98690 1.000 20.80490 ? 115 LEU A CA  1 
ATOM   864  C C   . LEU A 1 113 ? -12.26305 4.92708   -17.34831 1.000 26.16769 ? 115 LEU A C   1 
ATOM   865  O O   . LEU A 1 113 ? -13.40249 5.19417   -17.74695 1.000 25.37436 ? 115 LEU A O   1 
ATOM   866  C CB  . LEU A 1 113 ? -11.91649 7.12445   -16.13348 1.000 23.02304 ? 115 LEU A CB  1 
ATOM   867  C CG  . LEU A 1 113 ? -12.47132 6.65227   -14.77835 1.000 23.48378 ? 115 LEU A CG  1 
ATOM   868  C CD1 . LEU A 1 113 ? -11.36410 6.15111   -13.84882 1.000 20.17059 ? 115 LEU A CD1 1 
ATOM   869  C CD2 . LEU A 1 113 ? -13.28679 7.75294   -14.09569 1.000 23.93004 ? 115 LEU A CD2 1 
ATOM   870  N N   . ALA A 1 114 ? -11.82395 3.67327   -17.22174 1.000 23.93675 ? 116 ALA A N   1 
ATOM   871  C CA  . ALA A 1 114 ? -12.67835 2.53333   -17.54142 1.000 25.21850 ? 116 ALA A CA  1 
ATOM   872  C C   . ALA A 1 114 ? -13.68762 2.30247   -16.42520 1.000 25.65141 ? 116 ALA A C   1 
ATOM   873  O O   . ALA A 1 114 ? -13.31139 2.20684   -15.25260 1.000 24.60264 ? 116 ALA A O   1 
ATOM   874  C CB  . ALA A 1 114 ? -11.84459 1.26871   -17.74789 1.000 26.21070 ? 116 ALA A CB  1 
ATOM   875  N N   . CYS A 1 115 ? -14.96738 2.17741   -16.79688 1.000 26.74631 ? 117 CYS A N   1 
ATOM   876  C CA  . CYS A 1 115 ? -16.05880 2.09209   -15.83512 1.000 27.04828 ? 117 CYS A CA  1 
ATOM   877  C C   . CYS A 1 115 ? -17.01787 0.96257   -16.18956 1.000 28.14004 ? 117 CYS A C   1 
ATOM   878  O O   . CYS A 1 115 ? -17.20359 0.62507   -17.36121 1.000 31.26788 ? 117 CYS A O   1 
ATOM   879  C CB  . CYS A 1 115 ? -16.87246 3.40301   -15.77368 1.000 28.73614 ? 117 CYS A CB  1 
ATOM   880  S SG  . CYS A 1 115 ? -16.00285 4.86894   -15.21062 1.000 30.22755 ? 117 CYS A SG  1 
ATOM   881  N N   . TYR A 1 116 ? -17.66982 0.41445   -15.16245 1.000 31.47756 ? 118 TYR A N   1 
ATOM   882  C CA  . TYR A 1 116 ? -18.66521 -0.64040  -15.33224 1.000 33.30605 ? 118 TYR A CA  1 
ATOM   883  C C   . TYR A 1 116 ? -19.92058 -0.23142  -14.58089 1.000 33.06537 ? 118 TYR A C   1 
ATOM   884  O O   . TYR A 1 116 ? -19.86588 0.01172   -13.37132 1.000 30.65343 ? 118 TYR A O   1 
ATOM   885  C CB  . TYR A 1 116 ? -18.15472 -1.98776  -14.81298 1.000 35.42689 ? 118 TYR A CB  1 
ATOM   886  N N   . ASN A 1 117 ? -21.03778 -0.13533  -15.30243 1.000 33.23329 ? 119 ASN A N   1 
ATOM   887  C CA  . ASN A 1 117 ? -22.33821 0.18938   -14.71076 1.000 37.90650 ? 119 ASN A CA  1 
ATOM   888  C C   . ASN A 1 117 ? -22.25977 1.45660   -13.86201 1.000 38.07160 ? 119 ASN A C   1 
ATOM   889  O O   . ASN A 1 117 ? -22.88564 1.56725   -12.80393 1.000 41.20684 ? 119 ASN A O   1 
ATOM   890  C CB  . ASN A 1 117 ? -22.87733 -0.98813  -13.89544 1.000 38.29629 ? 119 ASN A CB  1 
ATOM   891  N N   . GLY A 1 118 ? -21.47565 2.42501   -14.33525 1.000 31.85973 ? 120 GLY A N   1 
ATOM   892  C CA  . GLY A 1 118 ? -21.36031 3.70598   -13.68649 1.000 30.23935 ? 120 GLY A CA  1 
ATOM   893  C C   . GLY A 1 118 ? -20.31942 3.79874   -12.58874 1.000 35.37945 ? 120 GLY A C   1 
ATOM   894  O O   . GLY A 1 118 ? -20.17229 4.87492   -11.99153 1.000 35.80146 ? 120 GLY A O   1 
ATOM   895  N N   . SER A 1 119 ? -19.59510 2.72563   -12.28672 1.000 32.16543 ? 121 SER A N   1 
ATOM   896  C CA  . SER A 1 119 ? -18.61686 2.85087   -11.22116 1.000 31.21836 ? 121 SER A CA  1 
ATOM   897  C C   . SER A 1 119 ? -17.20295 2.69981   -11.77726 1.000 32.86736 ? 121 SER A C   1 
ATOM   898  O O   . SER A 1 119 ? -16.91576 1.73597   -12.50574 1.000 27.21960 ? 121 SER A O   1 
ATOM   899  C CB  . SER A 1 119 ? -18.86794 1.83587   -10.09817 1.000 36.64368 ? 121 SER A CB  1 
ATOM   900  O OG  . SER A 1 119 ? -18.56450 0.52706   -10.51682 1.000 47.25265 ? 121 SER A OG  1 
ATOM   901  N N   . PRO A 1 120 ? -16.30929 3.63812   -11.47393 1.000 29.39710 ? 122 PRO A N   1 
ATOM   902  C CA  . PRO A 1 120 ? -14.95561 3.59498   -12.04022 1.000 28.99066 ? 122 PRO A CA  1 
ATOM   903  C C   . PRO A 1 120 ? -14.20979 2.34773   -11.59269 1.000 29.29100 ? 122 PRO A C   1 
ATOM   904  O O   . PRO A 1 120 ? -14.26657 1.94246   -10.42732 1.000 27.98625 ? 122 PRO A O   1 
ATOM   905  C CB  . PRO A 1 120 ? -14.30160 4.87153   -11.49394 1.000 30.13591 ? 122 PRO A CB  1 
ATOM   906  C CG  . PRO A 1 120 ? -15.44582 5.77203   -11.13252 1.000 31.15847 ? 122 PRO A CG  1 
ATOM   907  C CD  . PRO A 1 120 ? -16.55024 4.85253   -10.68170 1.000 31.40262 ? 122 PRO A CD  1 
ATOM   908  N N   . SER A 1 121 ? -13.53003 1.72503   -12.54226 1.000 25.62795 ? 123 SER A N   1 
ATOM   909  C CA  . SER A 1 121 ? -12.81028 0.49234   -12.27883 1.000 27.81182 ? 123 SER A CA  1 
ATOM   910  C C   . SER A 1 121 ? -11.29865 0.60805   -12.46882 1.000 26.38150 ? 123 SER A C   1 
ATOM   911  O O   . SER A 1 121 ? -10.54952 -0.05223  -11.75148 1.000 25.81046 ? 123 SER A O   1 
ATOM   912  C CB  . SER A 1 121 ? -13.36858 -0.62537  -13.17868 1.000 30.30593 ? 123 SER A CB  1 
ATOM   913  O OG  . SER A 1 121 ? -12.37080 -1.56788  -13.50386 1.000 39.72772 ? 123 SER A OG  1 
ATOM   914  N N   . GLY A 1 122 ? -10.83292 1.43631   -13.39122 1.000 25.55313 ? 124 GLY A N   1 
ATOM   915  C CA  . GLY A 1 122 ? -9.40064  1.58577   -13.59260 1.000 25.68173 ? 124 GLY A CA  1 
ATOM   916  C C   . GLY A 1 122 ? -9.14123  2.72358   -14.55007 1.000 25.86951 ? 124 GLY A C   1 
ATOM   917  O O   . GLY A 1 122 ? -10.04678 3.21776   -15.22695 1.000 25.02444 ? 124 GLY A O   1 
ATOM   918  N N   . VAL A 1 123 ? -7.87893  3.13513   -14.60749 1.000 24.43856 ? 125 VAL A N   1 
ATOM   919  C CA  . VAL A 1 123 ? -7.49112  4.24786   -15.45823 1.000 22.13834 ? 125 VAL A CA  1 
ATOM   920  C C   . VAL A 1 123 ? -6.17904  3.89768   -16.14333 1.000 27.28924 ? 125 VAL A C   1 
ATOM   921  O O   . VAL A 1 123 ? -5.31676  3.21848   -15.57424 1.000 23.66675 ? 125 VAL A O   1 
ATOM   922  C CB  . VAL A 1 123 ? -7.38985  5.57091   -14.66383 1.000 26.25297 ? 125 VAL A CB  1 
ATOM   923  C CG1 . VAL A 1 123 ? -6.21638  5.53883   -13.70799 1.000 29.14785 ? 125 VAL A CG1 1 
ATOM   924  C CG2 . VAL A 1 123 ? -7.29120  6.77951   -15.61260 1.000 23.53737 ? 125 VAL A CG2 1 
ATOM   925  N N   . TYR A 1 124 ? -6.04587  4.34275   -17.39006 1.000 27.05432 ? 126 TYR A N   1 
ATOM   926  C CA  . TYR A 1 124 ? -4.82810  4.07708   -18.14356 1.000 28.45050 ? 126 TYR A CA  1 
ATOM   927  C C   . TYR A 1 124 ? -4.59850  5.19304   -19.14751 1.000 28.92859 ? 126 TYR A C   1 
ATOM   928  O O   . TYR A 1 124 ? -5.53423  5.87559   -19.57532 1.000 25.23276 ? 126 TYR A O   1 
ATOM   929  C CB  . TYR A 1 124 ? -4.87826  2.70847   -18.84282 1.000 28.88477 ? 126 TYR A CB  1 
ATOM   930  C CG  . TYR A 1 124 ? -6.02203  2.50940   -19.84285 1.000 31.01721 ? 126 TYR A CG  1 
ATOM   931  C CD1 . TYR A 1 124 ? -7.26533  2.03138   -19.43082 1.000 30.15223 ? 126 TYR A CD1 1 
ATOM   932  C CD2 . TYR A 1 124 ? -5.83893  2.77068   -21.20269 1.000 30.91033 ? 126 TYR A CD2 1 
ATOM   933  C CE1 . TYR A 1 124 ? -8.30441  1.82822   -20.34618 1.000 32.74531 ? 126 TYR A CE1 1 
ATOM   934  C CE2 . TYR A 1 124 ? -6.87520  2.57560   -22.12505 1.000 30.06994 ? 126 TYR A CE2 1 
ATOM   935  C CZ  . TYR A 1 124 ? -8.09822  2.10761   -21.69300 1.000 37.17859 ? 126 TYR A CZ  1 
ATOM   936  O OH  . TYR A 1 124 ? -9.10647  1.91640   -22.61613 1.000 32.62030 ? 126 TYR A OH  1 
ATOM   937  N N   . GLN A 1 125 ? -3.33628  5.37388   -19.50577 1.000 23.53308 ? 127 GLN A N   1 
ATOM   938  C CA  . GLN A 1 125 ? -2.91338  6.34535   -20.49565 1.000 26.80424 ? 127 GLN A CA  1 
ATOM   939  C C   . GLN A 1 125 ? -2.78483  5.64352   -21.84260 1.000 28.90577 ? 127 GLN A C   1 
ATOM   940  O O   . GLN A 1 125 ? -2.29348  4.51295   -21.91180 1.000 28.46752 ? 127 GLN A O   1 
ATOM   941  C CB  . GLN A 1 125 ? -1.57531  6.96883   -20.07886 1.000 28.14929 ? 127 GLN A CB  1 
ATOM   942  C CG  . GLN A 1 125 ? -0.99391  7.95854   -21.06373 1.000 26.41953 ? 127 GLN A CG  1 
ATOM   943  C CD  . GLN A 1 125 ? -1.69968  9.30477   -21.01803 1.000 30.76682 ? 127 GLN A CD  1 
ATOM   944  O OE1 . GLN A 1 125 ? -2.70371  9.48329   -20.30931 1.000 27.80813 ? 127 GLN A OE1 1 
ATOM   945  N NE2 . GLN A 1 125 ? -1.16809  10.26583  -21.75871 1.000 28.03479 ? 127 GLN A NE2 1 
ATOM   946  N N   . CYS A 1 126 ? -3.23119  6.30342   -22.91253 1.000 25.89290 ? 128 CYS A N   1 
ATOM   947  C CA  . CYS A 1 126 ? -3.12825  5.69430   -24.23715 1.000 26.94574 ? 128 CYS A CA  1 
ATOM   948  C C   . CYS A 1 126 ? -2.93779  6.76849   -25.29374 1.000 28.09672 ? 128 CYS A C   1 
ATOM   949  O O   . CYS A 1 126 ? -2.96236  7.96521   -25.00815 1.000 26.64429 ? 128 CYS A O   1 
ATOM   950  C CB  . CYS A 1 126 ? -4.36561  4.85411   -24.57361 1.000 29.73193 ? 128 CYS A CB  1 
ATOM   951  S SG  . CYS A 1 126 ? -5.87916  5.83061   -24.75067 1.000 32.20445 ? 128 CYS A SG  1 
ATOM   952  N N   . ALA A 1 127 ? -2.73430  6.31289   -26.52939 1.000 27.97231 ? 129 ALA A N   1 
ATOM   953  C CA  . ALA A 1 127 ? -2.79837  7.16371   -27.70625 1.000 28.31780 ? 129 ALA A CA  1 
ATOM   954  C C   . ALA A 1 127 ? -3.92712  6.69286   -28.61324 1.000 26.86144 ? 129 ALA A C   1 
ATOM   955  O O   . ALA A 1 127 ? -4.23330  5.50130   -28.69692 1.000 30.49412 ? 129 ALA A O   1 
ATOM   956  C CB  . ALA A 1 127 ? -1.46414  7.17263   -28.48922 1.000 27.60761 ? 129 ALA A CB  1 
ATOM   957  N N   . MET A 1 128 ? -4.56614  7.65119   -29.26531 1.000 23.70269 ? 130 MET A N   1 
ATOM   958  C CA  . MET A 1 128 ? -5.43178  7.35150   -30.38992 1.000 26.14524 ? 130 MET A CA  1 
ATOM   959  C C   . MET A 1 128 ? -4.57707  6.79878   -31.52489 1.000 27.37401 ? 130 MET A C   1 
ATOM   960  O O   . MET A 1 128 ? -3.66974  7.48254   -32.00759 1.000 25.77386 ? 130 MET A O   1 
ATOM   961  C CB  . MET A 1 128 ? -6.16568  8.62821   -30.79539 1.000 27.56810 ? 130 MET A CB  1 
ATOM   962  C CG  . MET A 1 128 ? -6.87459  8.62863   -32.12528 1.000 34.43116 ? 130 MET A CG  1 
ATOM   963  S SD  . MET A 1 128 ? -8.46823  7.85110   -32.07966 1.000 40.96947 ? 130 MET A SD  1 
ATOM   964  C CE  . MET A 1 128 ? -9.38780  8.85115   -30.89287 1.000 31.00378 ? 130 MET A CE  1 
ATOM   965  N N   . ARG A 1 129 ? -4.82007  5.54670   -31.90912 1.000 28.30628 ? 131 ARG A N   1 
ATOM   966  C CA  . ARG A 1 129 ? -4.00536  4.92001   -32.94452 1.000 27.50606 ? 131 ARG A CA  1 
ATOM   967  C C   . ARG A 1 129 ? -4.26133  5.58415   -34.29340 1.000 26.70474 ? 131 ARG A C   1 
ATOM   968  O O   . ARG A 1 129 ? -5.33107  6.16573   -34.52343 1.000 27.11777 ? 131 ARG A O   1 
ATOM   969  C CB  . ARG A 1 129 ? -4.29729  3.42312   -33.04229 1.000 25.40462 ? 131 ARG A CB  1 
ATOM   970  C CG  . ARG A 1 129 ? -4.07456  2.62076   -31.75180 1.000 23.29148 ? 131 ARG A CG  1 
ATOM   971  C CD  . ARG A 1 129 ? -2.68892  2.87345   -31.14080 1.000 24.74163 ? 131 ARG A CD  1 
ATOM   972  N NE  . ARG A 1 129 ? -1.60653  2.67791   -32.10452 1.000 28.73161 ? 131 ARG A NE  1 
ATOM   973  C CZ  . ARG A 1 129 ? -0.32975  2.94761   -31.83063 1.000 31.17437 ? 131 ARG A CZ  1 
ATOM   974  N NH1 . ARG A 1 129 ? -0.00225  3.42008   -30.63906 1.000 23.58528 ? 131 ARG A NH1 1 
ATOM   975  N NH2 . ARG A 1 129 ? 0.61602   2.74292   -32.73858 1.000 25.95797 ? 131 ARG A NH2 1 
ATOM   976  N N   . PRO A 1 130 ? -3.28845  5.50494   -35.21018 1.000 24.07515 ? 132 PRO A N   1 
ATOM   977  C CA  . PRO A 1 130 ? -3.52266  6.02399   -36.56517 1.000 25.64077 ? 132 PRO A CA  1 
ATOM   978  C C   . PRO A 1 130 ? -4.75638  5.45173   -37.24349 1.000 24.09414 ? 132 PRO A C   1 
ATOM   979  O O   . PRO A 1 130 ? -5.31479  6.11459   -38.12307 1.000 28.03101 ? 132 PRO A O   1 
ATOM   980  C CB  . PRO A 1 130 ? -2.23675  5.63476   -37.32006 1.000 24.85030 ? 132 PRO A CB  1 
ATOM   981  C CG  . PRO A 1 130 ? -1.16998  5.59678   -36.23553 1.000 22.75002 ? 132 PRO A CG  1 
ATOM   982  C CD  . PRO A 1 130 ? -1.88497  5.06286   -35.00574 1.000 25.07853 ? 132 PRO A CD  1 
ATOM   983  N N   . ASN A 1 131 ? -5.18952  4.24378   -36.89422 1.000 25.53887 ? 133 ASN A N   1 
ATOM   984  C CA  . ASN A 1 131 ? -6.40250  3.69594   -37.49365 1.000 30.29828 ? 133 ASN A CA  1 
ATOM   985  C C   . ASN A 1 131 ? -7.66672  4.10680   -36.72748 1.000 31.87245 ? 133 ASN A C   1 
ATOM   986  O O   . ASN A 1 131 ? -8.73398  3.52119   -36.95129 1.000 29.59296 ? 133 ASN A O   1 
ATOM   987  C CB  . ASN A 1 131 ? -6.30702  2.16677   -37.60962 1.000 28.60572 ? 133 ASN A CB  1 
ATOM   988  C CG  . ASN A 1 131 ? -6.21008  1.47221   -36.26908 1.000 32.68080 ? 133 ASN A CG  1 
ATOM   989  O OD1 . ASN A 1 131 ? -6.31391  2.09542   -35.21318 1.000 29.51324 ? 133 ASN A OD1 1 
ATOM   990  N ND2 . ASN A 1 131 ? -6.02902  0.15738   -36.30609 1.000 37.53033 ? 133 ASN A ND2 1 
ATOM   991  N N   . PHE A 1 132 ? -7.55434  5.08759   -35.82970 1.000 29.99615 ? 134 PHE A N   1 
ATOM   992  C CA  . PHE A 1 132 ? -8.67047  5.68088   -35.08867 1.000 29.94550 ? 134 PHE A CA  1 
ATOM   993  C C   . PHE A 1 132 ? -9.27702  4.74240   -34.05359 1.000 30.76784 ? 134 PHE A C   1 
ATOM   994  O O   . PHE A 1 132 ? -10.44743 4.89746   -33.69158 1.000 34.52935 ? 134 PHE A O   1 
ATOM   995  C CB  . PHE A 1 132 ? -9.76736  6.18549   -36.03929 1.000 28.50535 ? 134 PHE A CB  1 
ATOM   996  C CG  . PHE A 1 132 ? -9.31961  7.30094   -36.94494 1.000 30.15919 ? 134 PHE A CG  1 
ATOM   997  C CD1 . PHE A 1 132 ? -9.33172  8.61217   -36.50501 1.000 31.72260 ? 134 PHE A CD1 1 
ATOM   998  C CD2 . PHE A 1 132 ? -8.86908  7.03160   -38.22992 1.000 34.04452 ? 134 PHE A CD2 1 
ATOM   999  C CE1 . PHE A 1 132 ? -8.92424  9.63831   -37.33038 1.000 34.18239 ? 134 PHE A CE1 1 
ATOM   1000 C CE2 . PHE A 1 132 ? -8.44877  8.05401   -39.06165 1.000 32.39751 ? 134 PHE A CE2 1 
ATOM   1001 C CZ  . PHE A 1 132 ? -8.47505  9.35781   -38.61202 1.000 35.10691 ? 134 PHE A CZ  1 
ATOM   1002 N N   . THR A 1 133 ? -8.52332  3.77197   -33.55520 1.000 28.94761 ? 135 THR A N   1 
ATOM   1003 C CA  . THR A 1 133 ? -8.99171  2.91580   -32.47967 1.000 29.08895 ? 135 THR A CA  1 
ATOM   1004 C C   . THR A 1 133 ? -8.12174  3.11796   -31.24616 1.000 34.34147 ? 135 THR A C   1 
ATOM   1005 O O   . THR A 1 133 ? -7.06065  3.75073   -31.29579 1.000 28.90155 ? 135 THR A O   1 
ATOM   1006 C CB  . THR A 1 133 ? -9.00628  1.43715   -32.89220 1.000 31.24616 ? 135 THR A CB  1 
ATOM   1007 O OG1 . THR A 1 133 ? -7.66183  0.97091   -33.09185 1.000 33.96755 ? 135 THR A OG1 1 
ATOM   1008 C CG2 . THR A 1 133 ? -9.82792  1.25414   -34.18417 1.000 30.35945 ? 135 THR A CG2 1 
ATOM   1009 N N   . ILE A 1 134 ? -8.59948  2.57860   -30.12743 1.000 27.85376 ? 136 ILE A N   1 
ATOM   1010 C CA  . ILE A 1 134 ? -7.89168  2.61963   -28.85207 1.000 35.16423 ? 136 ILE A CA  1 
ATOM   1011 C C   . ILE A 1 134 ? -7.60938  1.19318   -28.41603 1.000 34.84553 ? 136 ILE A C   1 
ATOM   1012 O O   . ILE A 1 134 ? -8.52829  0.36745   -28.35011 1.000 37.15656 ? 136 ILE A O   1 
ATOM   1013 C CB  . ILE A 1 134 ? -8.69860  3.35160   -27.76353 1.000 35.54527 ? 136 ILE A CB  1 
ATOM   1014 C CG1 . ILE A 1 134 ? -9.14121  4.73128   -28.24297 1.000 34.95621 ? 136 ILE A CG1 1 
ATOM   1015 C CG2 . ILE A 1 134 ? -7.89085  3.43454   -26.46896 1.000 34.72335 ? 136 ILE A CG2 1 
ATOM   1016 C CD1 . ILE A 1 134 ? -8.00525  5.60517   -28.65653 1.000 35.08279 ? 136 ILE A CD1 1 
ATOM   1017 N N   . LYS A 1 135 ? -6.34085  0.90821   -28.13333 1.000 36.28175 ? 137 LYS A N   1 
ATOM   1018 C CA  . LYS A 1 135 ? -5.92175  -0.34210  -27.51253 1.000 38.90020 ? 137 LYS A CA  1 
ATOM   1019 C C   . LYS A 1 135 ? -6.33525  -0.28550  -26.05145 1.000 42.74846 ? 137 LYS A C   1 
ATOM   1020 O O   . LYS A 1 135 ? -5.65913  0.32748   -25.22094 1.000 48.57701 ? 137 LYS A O   1 
ATOM   1021 C CB  . LYS A 1 135 ? -4.41330  -0.53387  -27.66263 1.000 36.65195 ? 137 LYS A CB  1 
ATOM   1022 N N   . GLY A 1 136 ? -7.46672  -0.89868  -25.73145 1.000 46.84506 ? 138 GLY A N   1 
ATOM   1023 C CA  . GLY A 1 136 ? -7.99719  -0.79111  -24.39083 1.000 51.84946 ? 138 GLY A CA  1 
ATOM   1024 C C   . GLY A 1 136 ? -8.55416  -2.08960  -23.85494 1.000 60.97473 ? 138 GLY A C   1 
ATOM   1025 O O   . GLY A 1 136 ? -9.38817  -2.73133  -24.50237 1.000 65.83787 ? 138 GLY A O   1 
ATOM   1026 N N   . SER A 1 137 ? -8.08317  -2.49120  -22.67247 1.000 62.54986 ? 139 SER A N   1 
ATOM   1027 C CA  . SER A 1 137 ? -8.60931  -3.65966  -21.96710 1.000 65.85920 ? 139 SER A CA  1 
ATOM   1028 C C   . SER A 1 137 ? -9.98932  -3.28976  -21.44268 1.000 67.17048 ? 139 SER A C   1 
ATOM   1029 O O   . SER A 1 137 ? -10.17010 -2.89329  -20.28753 1.000 70.41192 ? 139 SER A O   1 
ATOM   1030 C CB  . SER A 1 137 ? -7.68130  -4.07667  -20.83499 1.000 64.31152 ? 139 SER A CB  1 
ATOM   1031 O OG  . SER A 1 137 ? -7.33888  -2.94977  -20.04679 1.000 63.65915 ? 139 SER A OG  1 
ATOM   1032 N N   . PHE A 1 138 ? -10.98236 -3.40592  -22.31706 1.000 67.22592 ? 140 PHE A N   1 
ATOM   1033 C CA  . PHE A 1 138 ? -12.30597 -2.87423  -22.02472 1.000 67.22611 ? 140 PHE A CA  1 
ATOM   1034 C C   . PHE A 1 138 ? -13.31555 -3.99604  -21.82377 1.000 69.81567 ? 140 PHE A C   1 
ATOM   1035 O O   . PHE A 1 138 ? -13.85706 -4.56057  -22.78377 1.000 68.51674 ? 140 PHE A O   1 
ATOM   1036 C CB  . PHE A 1 138 ? -12.73327 -1.87167  -23.08809 1.000 65.10540 ? 140 PHE A CB  1 
ATOM   1037 C CG  . PHE A 1 138 ? -12.51375 -0.46490  -22.64572 1.000 63.41647 ? 140 PHE A CG  1 
ATOM   1038 C CD1 . PHE A 1 138 ? -13.19840 0.59755   -23.21463 1.000 57.56950 ? 140 PHE A CD1 1 
ATOM   1039 C CD2 . PHE A 1 138 ? -11.61241 -0.21616  -21.60943 1.000 55.50677 ? 140 PHE A CD2 1 
ATOM   1040 C CE1 . PHE A 1 138 ? -12.98496 1.88129   -22.76230 1.000 50.88037 ? 140 PHE A CE1 1 
ATOM   1041 C CE2 . PHE A 1 138 ? -11.40468 1.04737   -21.16076 1.000 46.81674 ? 140 PHE A CE2 1 
ATOM   1042 C CZ  . PHE A 1 138 ? -12.08383 2.09996   -21.73507 1.000 49.69754 ? 140 PHE A CZ  1 
ATOM   1043 N N   . LEU A 1 139 ? -13.54018 -4.28421  -20.53992 1.000 66.80304 ? 141 LEU A N   1 
ATOM   1044 C CA  . LEU A 1 139 ? -14.55537 -5.16283  -19.98311 1.000 66.22729 ? 141 LEU A CA  1 
ATOM   1045 C C   . LEU A 1 139 ? -15.91824 -5.02088  -20.64922 1.000 66.04069 ? 141 LEU A C   1 
ATOM   1046 O O   . LEU A 1 139 ? -16.24283 -3.96641  -21.20988 1.000 69.55796 ? 141 LEU A O   1 
ATOM   1047 C CB  . LEU A 1 139 ? -14.68643 -4.86504  -18.48804 1.000 68.40303 ? 141 LEU A CB  1 
ATOM   1048 C CG  . LEU A 1 139 ? -14.97350 -3.39577  -18.10839 1.000 60.41704 ? 141 LEU A CG  1 
ATOM   1049 C CD1 . LEU A 1 139 ? -15.98559 -3.34549  -16.99012 1.000 58.10838 ? 141 LEU A CD1 1 
ATOM   1050 C CD2 . LEU A 1 139 ? -13.71142 -2.61166  -17.70992 1.000 58.49439 ? 141 LEU A CD2 1 
ATOM   1051 N N   . ALA A 1 140 ? -16.73251 -6.07357  -20.58564 1.000 67.55003 ? 142 ALA A N   1 
ATOM   1052 C CA  . ALA A 1 140 ? -18.15025 -5.90125  -20.85434 1.000 66.62796 ? 142 ALA A CA  1 
ATOM   1053 C C   . ALA A 1 140 ? -18.67274 -4.76744  -19.98396 1.000 64.32033 ? 142 ALA A C   1 
ATOM   1054 O O   . ALA A 1 140 ? -18.24890 -4.59893  -18.83594 1.000 63.73274 ? 142 ALA A O   1 
ATOM   1055 C CB  . ALA A 1 140 ? -18.91953 -7.19529  -20.57613 1.000 65.18551 ? 142 ALA A CB  1 
ATOM   1056 N N   . GLY A 1 141 ? -19.55578 -3.95628  -20.55093 1.000 58.57257 ? 143 GLY A N   1 
ATOM   1057 C CA  . GLY A 1 141 ? -20.10708 -2.84965  -19.79995 1.000 57.86414 ? 143 GLY A CA  1 
ATOM   1058 C C   . GLY A 1 141 ? -19.25723 -1.59896  -19.73886 1.000 43.24531 ? 143 GLY A C   1 
ATOM   1059 O O   . GLY A 1 141 ? -19.58990 -0.68503  -18.97424 1.000 43.13480 ? 143 GLY A O   1 
ATOM   1060 N N   . SER A 1 142 ? -18.18355 -1.50913  -20.51658 1.000 42.63996 ? 144 SER A N   1 
ATOM   1061 C CA  . SER A 1 142 ? -17.39777 -0.28668  -20.46186 1.000 37.80532 ? 144 SER A CA  1 
ATOM   1062 C C   . SER A 1 142 ? -17.93039 0.80942   -21.37763 1.000 31.08342 ? 144 SER A C   1 
ATOM   1063 O O   . SER A 1 142 ? -17.38576 1.91169   -21.35352 1.000 25.28904 ? 144 SER A O   1 
ATOM   1064 C CB  . SER A 1 142 ? -15.92349 -0.57197  -20.78254 1.000 42.59789 ? 144 SER A CB  1 
ATOM   1065 O OG  . SER A 1 142 ? -15.75838 -1.07151  -22.09346 1.000 50.73374 ? 144 SER A OG  1 
ATOM   1066 N N   . CYS A 1 143 ? -18.99345 0.56652   -22.15624 1.000 32.93219 ? 145 CYS A N   1 
ATOM   1067 C CA  . CYS A 1 143 ? -19.52174 1.62203   -23.01563 1.000 25.53808 ? 145 CYS A CA  1 
ATOM   1068 C C   . CYS A 1 143 ? -19.84587 2.88200   -22.21912 1.000 25.91575 ? 145 CYS A C   1 
ATOM   1069 O O   . CYS A 1 143 ? -20.40921 2.82444   -21.11909 1.000 25.55881 ? 145 CYS A O   1 
ATOM   1070 C CB  . CYS A 1 143 ? -20.78018 1.15080   -23.75166 1.000 27.54326 ? 145 CYS A CB  1 
ATOM   1071 S SG  . CYS A 1 143 ? -20.46737 -0.17199  -24.90499 1.000 37.39038 ? 145 CYS A SG  1 
ATOM   1072 N N   . GLY A 1 144 ? -19.50818 4.03068   -22.79671 1.000 25.07083 ? 146 GLY A N   1 
ATOM   1073 C CA  . GLY A 1 144 ? -19.73009 5.30992   -22.15354 1.000 26.03550 ? 146 GLY A CA  1 
ATOM   1074 C C   . GLY A 1 144 ? -18.56459 5.81832   -21.32371 1.000 26.05606 ? 146 GLY A C   1 
ATOM   1075 O O   . GLY A 1 144 ? -18.61067 6.96621   -20.87109 1.000 24.33063 ? 146 GLY A O   1 
ATOM   1076 N N   . SER A 1 145 ? -17.55184 4.98749   -21.07396 1.000 23.20421 ? 147 SER A N   1 
ATOM   1077 C CA  . SER A 1 145 ? -16.32328 5.45702   -20.43901 1.000 25.54705 ? 147 SER A CA  1 
ATOM   1078 C C   . SER A 1 145 ? -15.68421 6.53657   -21.30092 1.000 24.49621 ? 147 SER A C   1 
ATOM   1079 O O   . SER A 1 145 ? -15.81203 6.52587   -22.52703 1.000 23.25504 ? 147 SER A O   1 
ATOM   1080 C CB  . SER A 1 145 ? -15.33714 4.29916   -20.26001 1.000 27.06686 ? 147 SER A CB  1 
ATOM   1081 O OG  . SER A 1 145 ? -15.85947 3.26147   -19.45031 1.000 28.24664 ? 147 SER A OG  1 
ATOM   1082 N N   . VAL A 1 146 ? -14.96296 7.46442   -20.66443 1.000 21.94130 ? 148 VAL A N   1 
ATOM   1083 C CA  . VAL A 1 146 ? -14.49937 8.64912   -21.37902 1.000 20.58655 ? 148 VAL A CA  1 
ATOM   1084 C C   . VAL A 1 146 ? -12.99381 8.79488   -21.27772 1.000 22.34985 ? 148 VAL A C   1 
ATOM   1085 O O   . VAL A 1 146 ? -12.35920 8.33199   -20.32036 1.000 21.75512 ? 148 VAL A O   1 
ATOM   1086 C CB  . VAL A 1 146 ? -15.17499 9.94327   -20.88427 1.000 21.19218 ? 148 VAL A CB  1 
ATOM   1087 C CG1 . VAL A 1 146 ? -16.69712 9.88151   -21.14595 1.000 24.86134 ? 148 VAL A CG1 1 
ATOM   1088 C CG2 . VAL A 1 146 ? -14.85378 10.19738  -19.43035 1.000 23.21600 ? 148 VAL A CG2 1 
ATOM   1089 N N   . GLY A 1 147 ? -12.43714 9.46725   -22.28273 1.000 22.05240 ? 149 GLY A N   1 
ATOM   1090 C CA  . GLY A 1 147 ? -11.02905 9.81574   -22.32185 1.000 23.77553 ? 149 GLY A CA  1 
ATOM   1091 C C   . GLY A 1 147 ? -10.86286 11.30980  -22.12524 1.000 23.31403 ? 149 GLY A C   1 
ATOM   1092 O O   . GLY A 1 147 ? -11.74970 12.09059  -22.47492 1.000 22.96547 ? 149 GLY A O   1 
ATOM   1093 N N   . PHE A 1 148 ? -9.72307  11.71392  -21.55654 1.000 21.49779 ? 150 PHE A N   1 
ATOM   1094 C CA  . PHE A 1 148 ? -9.58206  13.09108  -21.10065 1.000 24.84428 ? 150 PHE A CA  1 
ATOM   1095 C C   . PHE A 1 148 ? -8.11892  13.42629  -20.86227 1.000 23.55538 ? 150 PHE A C   1 
ATOM   1096 O O   . PHE A 1 148 ? -7.27881  12.54695  -20.63410 1.000 25.06548 ? 150 PHE A O   1 
ATOM   1097 C CB  . PHE A 1 148 ? -10.37816 13.34738  -19.80539 1.000 22.24476 ? 150 PHE A CB  1 
ATOM   1098 C CG  . PHE A 1 148 ? -9.93475  12.48673  -18.65442 1.000 21.25814 ? 150 PHE A CG  1 
ATOM   1099 C CD1 . PHE A 1 148 ? -10.41929 11.18537  -18.51556 1.000 24.66278 ? 150 PHE A CD1 1 
ATOM   1100 C CD2 . PHE A 1 148 ? -9.02159  12.96393  -17.72710 1.000 24.39422 ? 150 PHE A CD2 1 
ATOM   1101 C CE1 . PHE A 1 148 ? -9.99679  10.37264  -17.46684 1.000 24.48666 ? 150 PHE A CE1 1 
ATOM   1102 C CE2 . PHE A 1 148 ? -8.59583  12.16120  -16.66753 1.000 25.50432 ? 150 PHE A CE2 1 
ATOM   1103 C CZ  . PHE A 1 148 ? -9.08524  10.85897  -16.54347 1.000 25.18100 ? 150 PHE A CZ  1 
ATOM   1104 N N   . ASN A 1 149 ? -7.83613  14.72221  -20.92317 1.000 21.29954 ? 151 ASN A N   1 
ATOM   1105 C CA  . ASN A 1 149 ? -6.59551  15.29350  -20.42453 1.000 24.31086 ? 151 ASN A CA  1 
ATOM   1106 C C   . ASN A 1 149 ? -6.93760  16.29004  -19.31968 1.000 30.05733 ? 151 ASN A C   1 
ATOM   1107 O O   . ASN A 1 149 ? -8.05521  16.81642  -19.24460 1.000 25.37467 ? 151 ASN A O   1 
ATOM   1108 C CB  . ASN A 1 149 ? -5.79907  15.97605  -21.55227 1.000 27.97583 ? 151 ASN A CB  1 
ATOM   1109 C CG  . ASN A 1 149 ? -5.15092  14.97055  -22.50536 1.000 30.73818 ? 151 ASN A CG  1 
ATOM   1110 O OD1 . ASN A 1 149 ? -4.03855  14.49059  -22.26134 1.000 28.11657 ? 151 ASN A OD1 1 
ATOM   1111 N ND2 . ASN A 1 149 ? -5.84093  14.65360  -23.59489 1.000 27.34298 ? 151 ASN A ND2 1 
ATOM   1112 N N   . ILE A 1 150 ? -5.98186  16.54567  -18.43378 1.000 26.33341 ? 152 ILE A N   1 
ATOM   1113 C CA  . ILE A 1 150 ? -6.18522  17.56056  -17.41190 1.000 27.97790 ? 152 ILE A CA  1 
ATOM   1114 C C   . ILE A 1 150 ? -5.04082  18.54683  -17.51937 1.000 34.33585 ? 152 ILE A C   1 
ATOM   1115 O O   . ILE A 1 150 ? -3.87358  18.15588  -17.42677 1.000 30.43628 ? 152 ILE A O   1 
ATOM   1116 C CB  . ILE A 1 150 ? -6.26859  16.97276  -15.99724 1.000 31.14768 ? 152 ILE A CB  1 
ATOM   1117 C CG1 . ILE A 1 150 ? -7.33499  15.87084  -15.93828 1.000 24.91671 ? 152 ILE A CG1 1 
ATOM   1118 C CG2 . ILE A 1 150 ? -6.60103  18.08851  -14.98413 1.000 31.46315 ? 152 ILE A CG2 1 
ATOM   1119 C CD1 . ILE A 1 150 ? -7.72973  15.49260  -14.50482 1.000 25.75439 ? 152 ILE A CD1 1 
ATOM   1120 N N   . ASP A 1 151 ? -5.37140  19.81567  -17.72739 1.000 33.88620 ? 153 ASP A N   1 
ATOM   1121 C CA  . ASP A 1 151 ? -4.37703  20.87578  -17.83195 1.000 36.38620 ? 153 ASP A CA  1 
ATOM   1122 C C   . ASP A 1 151 ? -4.82339  22.01550  -16.93918 1.000 38.27070 ? 153 ASP A C   1 
ATOM   1123 O O   . ASP A 1 151 ? -5.91135  22.56531  -17.14264 1.000 36.88725 ? 153 ASP A O   1 
ATOM   1124 C CB  . ASP A 1 151 ? -4.21691  21.34802  -19.28051 1.000 35.98481 ? 153 ASP A CB  1 
ATOM   1125 C CG  . ASP A 1 151 ? -3.68614  20.25415  -20.18661 1.000 39.17786 ? 153 ASP A CG  1 
ATOM   1126 O OD1 . ASP A 1 151 ? -2.50406  19.88400  -20.02836 1.000 38.50980 ? 153 ASP A OD1 1 
ATOM   1127 O OD2 . ASP A 1 151 ? -4.44613  19.75988  -21.05136 1.000 39.44566 ? 153 ASP A OD2 1 
ATOM   1128 N N   . TYR A 1 152 ? -3.99527  22.34585  -15.94272 1.000 40.39405 ? 154 TYR A N   1 
ATOM   1129 C CA  . TYR A 1 152 ? -4.27198  23.42653  -14.99579 1.000 38.10572 ? 154 TYR A CA  1 
ATOM   1130 C C   . TYR A 1 152 ? -5.68153  23.30007  -14.42054 1.000 37.57519 ? 154 TYR A C   1 
ATOM   1131 O O   . TYR A 1 152 ? -6.47310  24.24453  -14.42226 1.000 40.63903 ? 154 TYR A O   1 
ATOM   1132 C CB  . TYR A 1 152 ? -4.06063  24.79369  -15.64876 1.000 41.91212 ? 154 TYR A CB  1 
ATOM   1133 N N   . ASP A 1 153 ? -5.99507  22.09694  -13.94475 1.000 36.85849 ? 155 ASP A N   1 
ATOM   1134 C CA  . ASP A 1 153 ? -7.24457  21.75821  -13.27486 1.000 37.43967 ? 155 ASP A CA  1 
ATOM   1135 C C   . ASP A 1 153 ? -8.45713  21.82979  -14.19601 1.000 33.27244 ? 155 ASP A C   1 
ATOM   1136 O O   . ASP A 1 153 ? -9.58858  21.75874  -13.70979 1.000 38.89798 ? 155 ASP A O   1 
ATOM   1137 C CB  . ASP A 1 153 ? -7.48839  22.64104  -12.04638 1.000 41.48326 ? 155 ASP A CB  1 
ATOM   1138 C CG  . ASP A 1 153 ? -6.49417  22.36896  -10.92531 1.000 49.16072 ? 155 ASP A CG  1 
ATOM   1139 O OD1 . ASP A 1 153 ? -6.18854  21.18055  -10.66562 1.000 47.35615 ? 155 ASP A OD1 1 
ATOM   1140 O OD2 . ASP A 1 153 ? -6.02546  23.34417  -10.30076 1.000 56.96597 ? 155 ASP A OD2 1 
ATOM   1141 N N   . CYS A 1 154 ? -8.25908  21.95242  -15.50807 1.000 33.52973 ? 156 CYS A N   1 
ATOM   1142 C CA  . CYS A 1 154 ? -9.35443  21.92432  -16.47482 1.000 33.65967 ? 156 CYS A CA  1 
ATOM   1143 C C   . CYS A 1 154 ? -9.34898  20.58070  -17.20115 1.000 33.27579 ? 156 CYS A C   1 
ATOM   1144 O O   . CYS A 1 154 ? -8.34137  20.20232  -17.80613 1.000 30.24692 ? 156 CYS A O   1 
ATOM   1145 C CB  . CYS A 1 154 ? -9.23736  23.07079  -17.47473 1.000 31.53848 ? 156 CYS A CB  1 
ATOM   1146 S SG  . CYS A 1 154 ? -10.55029 23.05128  -18.72467 1.000 35.23922 ? 156 CYS A SG  1 
ATOM   1147 N N   . VAL A 1 155 ? -10.46735 19.86333  -17.13843 1.000 27.43876 ? 157 VAL A N   1 
ATOM   1148 C CA  . VAL A 1 155 ? -10.58386 18.54815  -17.76681 1.000 24.54750 ? 157 VAL A CA  1 
ATOM   1149 C C   . VAL A 1 155 ? -11.04257 18.74026  -19.20347 1.000 29.57835 ? 157 VAL A C   1 
ATOM   1150 O O   . VAL A 1 155 ? -12.12042 19.29195  -19.45018 1.000 31.48516 ? 157 VAL A O   1 
ATOM   1151 C CB  . VAL A 1 155 ? -11.56178 17.64500  -16.99435 1.000 27.65512 ? 157 VAL A CB  1 
ATOM   1152 C CG1 . VAL A 1 155 ? -11.66232 16.25936  -17.63973 1.000 22.98645 ? 157 VAL A CG1 1 
ATOM   1153 C CG2 . VAL A 1 155 ? -11.13893 17.53070  -15.52742 1.000 29.06620 ? 157 VAL A CG2 1 
ATOM   1154 N N   . SER A 1 156 ? -10.23458 18.28219  -20.15179 1.000 22.59045 ? 158 SER A N   1 
ATOM   1155 C CA  . SER A 1 156 ? -10.60329 18.27482  -21.56225 1.000 24.68296 ? 158 SER A CA  1 
ATOM   1156 C C   . SER A 1 156 ? -11.09241 16.88041  -21.92813 1.000 24.52823 ? 158 SER A C   1 
ATOM   1157 O O   . SER A 1 156 ? -10.29967 15.93809  -21.97861 1.000 24.68837 ? 158 SER A O   1 
ATOM   1158 C CB  . SER A 1 156 ? -9.40567  18.66333  -22.42647 1.000 33.46986 ? 158 SER A CB  1 
ATOM   1159 O OG  . SER A 1 156 ? -9.31184  20.06514  -22.51733 1.000 41.28785 ? 158 SER A OG  1 
ATOM   1160 N N   . PHE A 1 157 ? -12.39421 16.74291  -22.19133 1.000 23.70301 ? 159 PHE A N   1 
ATOM   1161 C CA  . PHE A 1 157 ? -12.95655 15.46096  -22.59676 1.000 21.53311 ? 159 PHE A CA  1 
ATOM   1162 C C   . PHE A 1 157 ? -12.83110 15.31803  -24.10724 1.000 24.20023 ? 159 PHE A C   1 
ATOM   1163 O O   . PHE A 1 157 ? -13.33219 16.15682  -24.86499 1.000 25.67576 ? 159 PHE A O   1 
ATOM   1164 C CB  . PHE A 1 157 ? -14.41779 15.34422  -22.15414 1.000 23.17125 ? 159 PHE A CB  1 
ATOM   1165 C CG  . PHE A 1 157 ? -14.59972 15.27002  -20.65839 1.000 23.50489 ? 159 PHE A CG  1 
ATOM   1166 C CD1 . PHE A 1 157 ? -14.31749 14.09498  -19.96506 1.000 23.47792 ? 159 PHE A CD1 1 
ATOM   1167 C CD2 . PHE A 1 157 ? -15.05113 16.37217  -19.94706 1.000 23.21005 ? 159 PHE A CD2 1 
ATOM   1168 C CE1 . PHE A 1 157 ? -14.48306 14.01340  -18.58279 1.000 24.04149 ? 159 PHE A CE1 1 
ATOM   1169 C CE2 . PHE A 1 157 ? -15.22949 16.29975  -18.56779 1.000 28.27632 ? 159 PHE A CE2 1 
ATOM   1170 C CZ  . PHE A 1 157 ? -14.93748 15.11629  -17.88110 1.000 25.76754 ? 159 PHE A CZ  1 
ATOM   1171 N N   . CYS A 1 158 ? -12.15774 14.26332  -24.55273 1.000 24.79612 ? 160 CYS A N   1 
ATOM   1172 C CA  . CYS A 1 158 ? -11.92598 14.07791  -25.97351 1.000 28.17154 ? 160 CYS A CA  1 
ATOM   1173 C C   . CYS A 1 158 ? -12.53489 12.80930  -26.55393 1.000 28.37926 ? 160 CYS A C   1 
ATOM   1174 O O   . CYS A 1 158 ? -12.54723 12.66304  -27.78178 1.000 27.06379 ? 160 CYS A O   1 
ATOM   1175 C CB  . CYS A 1 158 ? -10.41628 14.08480  -26.27020 1.000 25.65831 ? 160 CYS A CB  1 
ATOM   1176 S SG  . CYS A 1 158 ? -9.46300  12.84812  -25.35120 1.000 28.26275 ? 160 CYS A SG  1 
ATOM   1177 N N   . TYR A 1 159 ? -13.04045 11.89613  -25.72850 1.000 25.41431 ? 161 TYR A N   1 
ATOM   1178 C CA  . TYR A 1 159 ? -13.35021 10.56007  -26.20500 1.000 21.96869 ? 161 TYR A CA  1 
ATOM   1179 C C   . TYR A 1 159 ? -14.43873 9.92987   -25.34675 1.000 24.37539 ? 161 TYR A C   1 
ATOM   1180 O O   . TYR A 1 159 ? -14.42779 10.07221  -24.12344 1.000 23.74345 ? 161 TYR A O   1 
ATOM   1181 C CB  . TYR A 1 159 ? -12.10005 9.68000   -26.16305 1.000 24.45443 ? 161 TYR A CB  1 
ATOM   1182 C CG  . TYR A 1 159 ? -12.33779 8.28481   -26.63046 1.000 20.56372 ? 161 TYR A CG  1 
ATOM   1183 C CD1 . TYR A 1 159 ? -12.41907 8.00598   -27.98294 1.000 26.03407 ? 161 TYR A CD1 1 
ATOM   1184 C CD2 . TYR A 1 159 ? -12.49286 7.23823   -25.72679 1.000 23.36768 ? 161 TYR A CD2 1 
ATOM   1185 C CE1 . TYR A 1 159 ? -12.64232 6.72331   -28.43768 1.000 27.99632 ? 161 TYR A CE1 1 
ATOM   1186 C CE2 . TYR A 1 159 ? -12.73794 5.94035   -26.17692 1.000 25.11032 ? 161 TYR A CE2 1 
ATOM   1187 C CZ  . TYR A 1 159 ? -12.79835 5.69593   -27.53988 1.000 26.45566 ? 161 TYR A CZ  1 
ATOM   1188 O OH  . TYR A 1 159 ? -13.02269 4.42867   -28.03742 1.000 27.32136 ? 161 TYR A OH  1 
ATOM   1189 N N   . MET A 1 160 ? -15.36531 9.22198   -25.99154 1.000 22.04930 ? 162 MET A N   1 
ATOM   1190 C CA  . MET A 1 160 ? -16.30873 8.35107   -25.29335 1.000 22.77198 ? 162 MET A CA  1 
ATOM   1191 C C   . MET A 1 160 ? -16.35062 7.02918   -26.04714 1.000 20.67631 ? 162 MET A C   1 
ATOM   1192 O O   . MET A 1 160 ? -16.50400 7.01928   -27.27170 1.000 23.22899 ? 162 MET A O   1 
ATOM   1193 C CB  . MET A 1 160 ? -17.71728 8.96785   -25.19706 1.000 22.50003 ? 162 MET A CB  1 
ATOM   1194 C CG  . MET A 1 160 ? -18.77978 7.97560   -24.72077 1.000 24.22533 ? 162 MET A CG  1 
ATOM   1195 S SD  . MET A 1 160 ? -20.36991 8.80729   -24.43532 1.000 27.19674 ? 162 MET A SD  1 
ATOM   1196 C CE  . MET A 1 160 ? -19.98190 9.67788   -22.90444 1.000 26.77089 ? 162 MET A CE  1 
ATOM   1197 N N   . ALA A 1 161 ? -16.17850 5.92487   -25.32299 1.000 22.76778 ? 163 ALA A N   1 
ATOM   1198 C CA  . ALA A 1 161 ? -16.15199 4.59858   -25.93297 1.000 23.80532 ? 163 ALA A CA  1 
ATOM   1199 C C   . ALA A 1 161 ? -17.56370 4.16205   -26.30834 1.000 26.42577 ? 163 ALA A C   1 
ATOM   1200 O O   . ALA A 1 161 ? -18.47394 4.23428   -25.47883 1.000 24.19104 ? 163 ALA A O   1 
ATOM   1201 C CB  . ALA A 1 161 ? -15.54057 3.58265   -24.96641 1.000 24.70680 ? 163 ALA A CB  1 
ATOM   1202 N N   . HIS A 1 162 ? -17.74874 3.71151   -27.55879 1.000 25.70705 ? 164 HIS A N   1 
ATOM   1203 C CA  . HIS A 1 162 ? -19.04292 3.17345   -27.98614 1.000 27.91169 ? 164 HIS A CA  1 
ATOM   1204 C C   . HIS A 1 162 ? -19.04358 1.67059   -28.24742 1.000 32.99741 ? 164 HIS A C   1 
ATOM   1205 O O   . HIS A 1 162 ? -20.06211 1.02431   -27.99481 1.000 28.93286 ? 164 HIS A O   1 
ATOM   1206 C CB  . HIS A 1 162 ? -19.55026 3.88550   -29.25356 1.000 24.00777 ? 164 HIS A CB  1 
ATOM   1207 C CG  . HIS A 1 162 ? -20.04378 5.28155   -29.02445 1.000 27.93958 ? 164 HIS A CG  1 
ATOM   1208 N ND1 . HIS A 1 162 ? -21.32336 5.68526   -29.35837 1.000 25.71915 ? 164 HIS A ND1 1 
ATOM   1209 C CD2 . HIS A 1 162 ? -19.42502 6.37460   -28.51434 1.000 24.10540 ? 164 HIS A CD2 1 
ATOM   1210 C CE1 . HIS A 1 162 ? -21.46977 6.96400   -29.06066 1.000 25.49131 ? 164 HIS A CE1 1 
ATOM   1211 N NE2 . HIS A 1 162 ? -20.33651 7.40325   -28.53782 1.000 25.68477 ? 164 HIS A NE2 1 
ATOM   1212 N N   . MET A 1 163 ? -17.95655 1.07847   -28.74945 1.000 28.10671 ? 165 MET A N   1 
ATOM   1213 C CA  . MET A 1 163 ? -18.03204 -0.34336  -29.06846 1.000 32.68694 ? 165 MET A CA  1 
ATOM   1214 C C   . MET A 1 163 ? -16.64615 -0.96796  -29.15478 1.000 37.23764 ? 165 MET A C   1 
ATOM   1215 O O   . MET A 1 163 ? -15.62479 -0.27916  -29.24719 1.000 24.72495 ? 165 MET A O   1 
ATOM   1216 C CB  . MET A 1 163 ? -18.77704 -0.57863  -30.38147 1.000 33.05481 ? 165 MET A CB  1 
ATOM   1217 C CG  . MET A 1 163 ? -18.05537 -0.00003  -31.55841 1.000 35.12110 ? 165 MET A CG  1 
ATOM   1218 S SD  . MET A 1 163 ? -19.20476 0.55400   -32.82282 1.000 44.59576 ? 165 MET A SD  1 
ATOM   1219 C CE  . MET A 1 163 ? -18.07688 1.44413   -33.89034 1.000 36.94070 ? 165 MET A CE  1 
ATOM   1220 N N   . GLU A 1 164 ? -16.63902 -2.30181  -29.14615 1.000 34.05623 ? 166 GLU A N   1 
ATOM   1221 C CA  . GLU A 1 164 ? -15.42716 -3.09498  -29.30560 1.000 41.54237 ? 166 GLU A CA  1 
ATOM   1222 C C   . GLU A 1 164 ? -15.36744 -3.63985  -30.72647 1.000 43.69346 ? 166 GLU A C   1 
ATOM   1223 O O   . GLU A 1 164 ? -16.36420 -4.15937  -31.24324 1.000 39.98632 ? 166 GLU A O   1 
ATOM   1224 C CB  . GLU A 1 164 ? -15.38333 -4.24451  -28.29576 1.000 48.45691 ? 166 GLU A CB  1 
ATOM   1225 N N   . LEU A 1 165 ? -14.21243 -3.49138  -31.36278 1.000 44.14627 ? 167 LEU A N   1 
ATOM   1226 C CA  . LEU A 1 165 ? -14.00819 -4.06719  -32.67490 1.000 43.56662 ? 167 LEU A CA  1 
ATOM   1227 C C   . LEU A 1 165 ? -13.56373 -5.52108  -32.52192 1.000 49.02706 ? 167 LEU A C   1 
ATOM   1228 O O   . LEU A 1 165 ? -13.06494 -5.91429  -31.46311 1.000 50.35879 ? 167 LEU A O   1 
ATOM   1229 C CB  . LEU A 1 165 ? -12.98423 -3.23977  -33.44463 1.000 42.56694 ? 167 LEU A CB  1 
ATOM   1230 C CG  . LEU A 1 165 ? -13.54145 -2.15502  -34.37599 1.000 45.69537 ? 167 LEU A CG  1 
ATOM   1231 C CD1 . LEU A 1 165 ? -15.07918 -2.12644  -34.40685 1.000 40.35146 ? 167 LEU A CD1 1 
ATOM   1232 C CD2 . LEU A 1 165 ? -12.98488 -0.78480  -34.01356 1.000 38.11720 ? 167 LEU A CD2 1 
ATOM   1233 N N   . PRO A 1 166 ? -13.75641 -6.34937  -33.55598 1.000 52.18327 ? 168 PRO A N   1 
ATOM   1234 C CA  . PRO A 1 166 ? -13.52784 -7.79775  -33.38573 1.000 56.10157 ? 168 PRO A CA  1 
ATOM   1235 C C   . PRO A 1 166 ? -12.14347 -8.16030  -32.86887 1.000 59.56103 ? 168 PRO A C   1 
ATOM   1236 O O   . PRO A 1 166 ? -11.99517 -9.18470  -32.18809 1.000 64.12417 ? 168 PRO A O   1 
ATOM   1237 C CB  . PRO A 1 166 ? -13.76603 -8.34848  -34.79809 1.000 55.20861 ? 168 PRO A CB  1 
ATOM   1238 C CG  . PRO A 1 166 ? -14.72380 -7.38081  -35.41012 1.000 53.56545 ? 168 PRO A CG  1 
ATOM   1239 C CD  . PRO A 1 166 ? -14.29124 -6.03610  -34.89435 1.000 49.25043 ? 168 PRO A CD  1 
ATOM   1240 N N   . THR A 1 167 ? -11.12955 -7.34400  -33.14489 1.000 56.53964 ? 169 THR A N   1 
ATOM   1241 C CA  . THR A 1 167 ? -9.76338  -7.63480  -32.73188 1.000 57.92524 ? 169 THR A CA  1 
ATOM   1242 C C   . THR A 1 167 ? -9.46341  -7.21274  -31.29731 1.000 57.91512 ? 169 THR A C   1 
ATOM   1243 O O   . THR A 1 167 ? -8.30638  -7.29455  -30.87449 1.000 58.96354 ? 169 THR A O   1 
ATOM   1244 C CB  . THR A 1 167 ? -8.77282  -6.95609  -33.67883 1.000 59.85069 ? 169 THR A CB  1 
ATOM   1245 O OG1 . THR A 1 167 ? -8.75408  -5.54922  -33.40708 1.000 57.87502 ? 169 THR A OG1 1 
ATOM   1246 C CG2 . THR A 1 167 ? -9.17109  -7.18883  -35.13468 1.000 54.64311 ? 169 THR A CG2 1 
ATOM   1247 N N   . GLY A 1 168 ? -10.46048 -6.74759  -30.54635 1.000 52.87782 ? 170 GLY A N   1 
ATOM   1248 C CA  . GLY A 1 168 ? -10.27774 -6.42249  -29.14516 1.000 54.62201 ? 170 GLY A CA  1 
ATOM   1249 C C   . GLY A 1 168 ? -10.01382 -4.95925  -28.83682 1.000 51.01152 ? 170 GLY A C   1 
ATOM   1250 O O   . GLY A 1 168 ? -9.90588  -4.60402  -27.65555 1.000 53.90555 ? 170 GLY A O   1 
ATOM   1251 N N   . VAL A 1 169 ? -9.89850  -4.10726  -29.85032 1.000 46.79764 ? 171 VAL A N   1 
ATOM   1252 C CA  . VAL A 1 169 ? -9.71790  -2.67731  -29.63983 1.000 45.30179 ? 171 VAL A CA  1 
ATOM   1253 C C   . VAL A 1 169 ? -11.09337 -2.02132  -29.59094 1.000 42.21880 ? 171 VAL A C   1 
ATOM   1254 O O   . VAL A 1 169 ? -12.09921 -2.61001  -29.99946 1.000 41.22359 ? 171 VAL A O   1 
ATOM   1255 C CB  . VAL A 1 169 ? -8.83356  -2.05596  -30.74161 1.000 38.92934 ? 171 VAL A CB  1 
ATOM   1256 C CG1 . VAL A 1 169 ? -7.43409  -2.68021  -30.72059 1.000 41.58351 ? 171 VAL A CG1 1 
ATOM   1257 C CG2 . VAL A 1 169 ? -9.46442  -2.26422  -32.09457 1.000 39.24917 ? 171 VAL A CG2 1 
ATOM   1258 N N   . HIS A 1 170 ? -11.16152 -0.79641  -29.07260 1.000 36.22226 ? 172 HIS A N   1 
ATOM   1259 C CA  . HIS A 1 170 ? -12.45021 -0.11942  -29.06723 1.000 34.65428 ? 172 HIS A CA  1 
ATOM   1260 C C   . HIS A 1 170 ? -12.42932 1.14653   -29.91841 1.000 31.91360 ? 172 HIS A C   1 
ATOM   1261 O O   . HIS A 1 170 ? -11.37418 1.67460   -30.29059 1.000 28.94020 ? 172 HIS A O   1 
ATOM   1262 C CB  . HIS A 1 170 ? -12.95710 0.15596   -27.63178 1.000 36.61467 ? 172 HIS A CB  1 
ATOM   1263 C CG  . HIS A 1 170 ? -12.08450 1.03982   -26.79518 1.000 40.57917 ? 172 HIS A CG  1 
ATOM   1264 N ND1 . HIS A 1 170 ? -12.32541 2.39070   -26.63732 1.000 38.86897 ? 172 HIS A ND1 1 
ATOM   1265 C CD2 . HIS A 1 170 ? -11.03026 0.75115   -25.99550 1.000 44.18753 ? 172 HIS A CD2 1 
ATOM   1266 C CE1 . HIS A 1 170 ? -11.42955 2.90255   -25.81106 1.000 41.96341 ? 172 HIS A CE1 1 
ATOM   1267 N NE2 . HIS A 1 170 ? -10.63043 1.92948   -25.40879 1.000 46.70881 ? 172 HIS A NE2 1 
ATOM   1268 N N   . ALA A 1 171 ? -13.63820 1.58536   -30.26847 1.000 26.29350 ? 173 ALA A N   1 
ATOM   1269 C CA  . ALA A 1 171 ? -13.89367 2.73891   -31.11270 1.000 25.83770 ? 173 ALA A CA  1 
ATOM   1270 C C   . ALA A 1 171 ? -14.96271 3.59896   -30.45303 1.000 27.21142 ? 173 ALA A C   1 
ATOM   1271 O O   . ALA A 1 171 ? -15.77992 3.09570   -29.67381 1.000 23.41048 ? 173 ALA A O   1 
ATOM   1272 C CB  . ALA A 1 171 ? -14.37067 2.31173   -32.52025 1.000 30.08514 ? 173 ALA A CB  1 
ATOM   1273 N N   . GLY A 1 172 ? -14.94884 4.88989   -30.76196 1.000 21.93711 ? 174 GLY A N   1 
ATOM   1274 C CA  . GLY A 1 172 ? -15.89508 5.80317   -30.14290 1.000 24.12412 ? 174 GLY A CA  1 
ATOM   1275 C C   . GLY A 1 172 ? -15.88961 7.18077   -30.77176 1.000 23.35021 ? 174 GLY A C   1 
ATOM   1276 O O   . GLY A 1 172 ? -15.40224 7.37456   -31.88728 1.000 26.01975 ? 174 GLY A O   1 
ATOM   1277 N N   . THR A 1 173 ? -16.42130 8.15090   -30.02413 1.000 23.19812 ? 175 THR A N   1 
ATOM   1278 C CA  . THR A 1 173 ? -16.74271 9.47053   -30.54958 1.000 21.43649 ? 175 THR A CA  1 
ATOM   1279 C C   . THR A 1 173 ? -16.08680 10.54091  -29.69426 1.000 22.01335 ? 175 THR A C   1 
ATOM   1280 O O   . THR A 1 173 ? -15.58043 10.27379  -28.59657 1.000 23.25795 ? 175 THR A O   1 
ATOM   1281 C CB  . THR A 1 173 ? -18.26554 9.72491   -30.54755 1.000 25.03880 ? 175 THR A CB  1 
ATOM   1282 O OG1 . THR A 1 173 ? -18.70607 9.70733   -29.18790 1.000 24.15340 ? 175 THR A OG1 1 
ATOM   1283 C CG2 . THR A 1 173 ? -19.00248 8.66189   -31.34165 1.000 24.63037 ? 175 THR A CG2 1 
ATOM   1284 N N   . ASP A 1 174 ? -16.11492 11.76907  -30.20018 1.000 20.64655 ? 176 ASP A N   1 
ATOM   1285 C CA  . ASP A 1 174 ? -15.89147 12.90826  -29.32703 1.000 23.34968 ? 176 ASP A CA  1 
ATOM   1286 C C   . ASP A 1 174 ? -17.16013 13.17598  -28.51793 1.000 26.20373 ? 176 ASP A C   1 
ATOM   1287 O O   . ASP A 1 174 ? -18.16466 12.45910  -28.62640 1.000 23.34365 ? 176 ASP A O   1 
ATOM   1288 C CB  . ASP A 1 174 ? -15.40655 14.13030  -30.12623 1.000 24.62141 ? 176 ASP A CB  1 
ATOM   1289 C CG  . ASP A 1 174 ? -16.40701 14.63304  -31.17823 1.000 29.78361 ? 176 ASP A CG  1 
ATOM   1290 O OD1 . ASP A 1 174 ? -17.64149 14.47075  -31.03586 1.000 27.30865 ? 176 ASP A OD1 1 
ATOM   1291 O OD2 . ASP A 1 174 ? -15.92698 15.22088  -32.17576 1.000 31.59636 ? 176 ASP A OD2 1 
ATOM   1292 N N   . LEU A 1 175 ? -17.11733 14.19991  -27.66803 1.000 25.74204 ? 177 LEU A N   1 
ATOM   1293 C CA  . LEU A 1 175 ? -18.27039 14.45392  -26.81386 1.000 25.65342 ? 177 LEU A CA  1 
ATOM   1294 C C   . LEU A 1 175 ? -19.36243 15.23323  -27.52936 1.000 27.83022 ? 177 LEU A C   1 
ATOM   1295 O O   . LEU A 1 175 ? -20.39605 15.52437  -26.92263 1.000 27.71455 ? 177 LEU A O   1 
ATOM   1296 C CB  . LEU A 1 175 ? -17.84377 15.17701  -25.53599 1.000 25.03820 ? 177 LEU A CB  1 
ATOM   1297 C CG  . LEU A 1 175 ? -17.51026 14.24384  -24.35493 1.000 25.34040 ? 177 LEU A CG  1 
ATOM   1298 C CD1 . LEU A 1 175 ? -18.73481 13.53828  -23.83258 1.000 25.96389 ? 177 LEU A CD1 1 
ATOM   1299 C CD2 . LEU A 1 175 ? -16.46357 13.19676  -24.74348 1.000 24.49691 ? 177 LEU A CD2 1 
ATOM   1300 N N   . GLU A 1 176 ? -19.16456 15.56845  -28.80143 1.000 29.35818 ? 178 GLU A N   1 
ATOM   1301 C CA  . GLU A 1 176 ? -20.25798 15.99719  -29.66132 1.000 30.90780 ? 178 GLU A CA  1 
ATOM   1302 C C   . GLU A 1 176 ? -20.82239 14.84033  -30.48293 1.000 26.99244 ? 178 GLU A C   1 
ATOM   1303 O O   . GLU A 1 176 ? -21.63254 15.06506  -31.38398 1.000 28.00712 ? 178 GLU A O   1 
ATOM   1304 C CB  . GLU A 1 176 ? -19.79746 17.14394  -30.56154 1.000 30.28663 ? 178 GLU A CB  1 
ATOM   1305 C CG  . GLU A 1 176 ? -19.42151 18.40002  -29.76722 1.000 39.60501 ? 178 GLU A CG  1 
ATOM   1306 C CD  . GLU A 1 176 ? -19.11619 19.60179  -30.64948 1.000 51.51702 ? 178 GLU A CD  1 
ATOM   1307 O OE1 . GLU A 1 176 ? -19.50103 20.73145  -30.27148 1.000 51.82882 ? 178 GLU A OE1 1 
ATOM   1308 O OE2 . GLU A 1 176 ? -18.49504 19.41648  -31.72160 1.000 53.76719 ? 178 GLU A OE2 1 
ATOM   1309 N N   . GLY A 1 177 ? -20.41505 13.60949  -30.18294 1.000 25.38459 ? 179 GLY A N   1 
ATOM   1310 C CA  . GLY A 1 177 ? -20.98059 12.43809  -30.81122 1.000 25.48698 ? 179 GLY A CA  1 
ATOM   1311 C C   . GLY A 1 177 ? -20.47072 12.11474  -32.19241 1.000 26.02905 ? 179 GLY A C   1 
ATOM   1312 O O   . GLY A 1 177 ? -21.05917 11.25789  -32.85623 1.000 25.23880 ? 179 GLY A O   1 
ATOM   1313 N N   . ASN A 1 178 ? -19.39723 12.75769  -32.65077 1.000 22.54819 ? 180 ASN A N   1 
ATOM   1314 C CA  . ASN A 1 178 ? -18.82460 12.46375  -33.96080 1.000 24.74287 ? 180 ASN A CA  1 
ATOM   1315 C C   . ASN A 1 178 ? -17.77930 11.37205  -33.80620 1.000 25.49458 ? 180 ASN A C   1 
ATOM   1316 O O   . ASN A 1 178 ? -16.82003 11.53352  -33.03978 1.000 24.67169 ? 180 ASN A O   1 
ATOM   1317 C CB  . ASN A 1 178 ? -18.19761 13.71070  -34.58304 1.000 27.94878 ? 180 ASN A CB  1 
ATOM   1318 C CG  . ASN A 1 178 ? -19.24495 14.70970  -35.05113 1.000 28.48690 ? 180 ASN A CG  1 
ATOM   1319 O OD1 . ASN A 1 178 ? -20.10037 14.38125  -35.86752 1.000 32.90915 ? 180 ASN A OD1 1 
ATOM   1320 N ND2 . ASN A 1 178 ? -19.19093 15.92389  -34.51551 1.000 29.79420 ? 180 ASN A ND2 1 
ATOM   1321 N N   . PHE A 1 179 ? -17.94028 10.28433  -34.55689 1.000 23.36893 ? 181 PHE A N   1 
ATOM   1322 C CA  . PHE A 1 179 ? -17.02932 9.15360   -34.41533 1.000 24.94499 ? 181 PHE A CA  1 
ATOM   1323 C C   . PHE A 1 179 ? -15.61230 9.52930   -34.84369 1.000 24.60113 ? 181 PHE A C   1 
ATOM   1324 O O   . PHE A 1 179 ? -15.39912 10.35365  -35.73838 1.000 23.69623 ? 181 PHE A O   1 
ATOM   1325 C CB  . PHE A 1 179 ? -17.50760 7.96168   -35.24276 1.000 22.40150 ? 181 PHE A CB  1 
ATOM   1326 C CG  . PHE A 1 179 ? -18.21951 6.90824   -34.44013 1.000 23.98227 ? 181 PHE A CG  1 
ATOM   1327 C CD1 . PHE A 1 179 ? -17.51010 5.90626   -33.80154 1.000 24.17123 ? 181 PHE A CD1 1 
ATOM   1328 C CD2 . PHE A 1 179 ? -19.61039 6.92365   -34.32978 1.000 26.42361 ? 181 PHE A CD2 1 
ATOM   1329 C CE1 . PHE A 1 179 ? -18.16365 4.92867   -33.06381 1.000 29.79155 ? 181 PHE A CE1 1 
ATOM   1330 C CE2 . PHE A 1 179 ? -20.28051 5.95190   -33.58171 1.000 25.34152 ? 181 PHE A CE2 1 
ATOM   1331 C CZ  . PHE A 1 179 ? -19.54633 4.94794   -32.94260 1.000 24.33886 ? 181 PHE A CZ  1 
ATOM   1332 N N   . TYR A 1 180 ? -14.63941 8.91138   -34.18087 1.000 26.02306 ? 182 TYR A N   1 
ATOM   1333 C CA  . TYR A 1 180 ? -13.26995 8.89129   -34.67279 1.000 27.52178 ? 182 TYR A CA  1 
ATOM   1334 C C   . TYR A 1 180 ? -13.14044 7.74996   -35.67330 1.000 26.24222 ? 182 TYR A C   1 
ATOM   1335 O O   . TYR A 1 180 ? -13.50965 6.60870   -35.37740 1.000 24.36708 ? 182 TYR A O   1 
ATOM   1336 C CB  . TYR A 1 180 ? -12.28265 8.72159   -33.51843 1.000 24.03159 ? 182 TYR A CB  1 
ATOM   1337 C CG  . TYR A 1 180 ? -12.19441 9.93726   -32.61797 1.000 29.50305 ? 182 TYR A CG  1 
ATOM   1338 C CD1 . TYR A 1 180 ? -11.47660 11.06523  -33.01274 1.000 28.31088 ? 182 TYR A CD1 1 
ATOM   1339 C CD2 . TYR A 1 180 ? -12.82102 9.95454   -31.36944 1.000 25.23678 ? 182 TYR A CD2 1 
ATOM   1340 C CE1 . TYR A 1 180 ? -11.37997 12.17901  -32.19410 1.000 28.42130 ? 182 TYR A CE1 1 
ATOM   1341 C CE2 . TYR A 1 180 ? -12.73796 11.07563  -30.53809 1.000 24.14129 ? 182 TYR A CE2 1 
ATOM   1342 C CZ  . TYR A 1 180 ? -12.01243 12.17737  -30.95601 1.000 24.00350 ? 182 TYR A CZ  1 
ATOM   1343 O OH  . TYR A 1 180 ? -11.91304 13.28932  -30.14808 1.000 25.61415 ? 182 TYR A OH  1 
ATOM   1344 N N   . GLY A 1 181 ? -12.65893 8.06156   -36.87083 1.000 26.22766 ? 183 GLY A N   1 
ATOM   1345 C CA  . GLY A 1 181 ? -12.49921 7.04228   -37.87396 1.000 25.11576 ? 183 GLY A CA  1 
ATOM   1346 C C   . GLY A 1 181 ? -13.77703 6.75376   -38.62795 1.000 27.34349 ? 183 GLY A C   1 
ATOM   1347 O O   . GLY A 1 181 ? -14.77581 7.47039   -38.50806 1.000 27.23590 ? 183 GLY A O   1 
ATOM   1348 N N   . PRO A 1 182 ? -13.75795 5.69147   -39.42962 1.000 32.32317 ? 184 PRO A N   1 
ATOM   1349 C CA  . PRO A 1 182 ? -14.87330 5.42349   -40.34453 1.000 29.90895 ? 184 PRO A CA  1 
ATOM   1350 C C   . PRO A 1 182 ? -15.95747 4.55197   -39.72238 1.000 36.19509 ? 184 PRO A C   1 
ATOM   1351 O O   . PRO A 1 182 ? -16.78041 3.97054   -40.43057 1.000 39.64887 ? 184 PRO A O   1 
ATOM   1352 C CB  . PRO A 1 182 ? -14.17656 4.71267   -41.51280 1.000 33.28138 ? 184 PRO A CB  1 
ATOM   1353 C CG  . PRO A 1 182 ? -13.08144 3.94432   -40.84470 1.000 36.42651 ? 184 PRO A CG  1 
ATOM   1354 C CD  . PRO A 1 182 ? -12.61575 4.78685   -39.67335 1.000 31.64552 ? 184 PRO A CD  1 
ATOM   1355 N N   . PHE A 1 183 ? -15.99330 4.47245   -38.40247 1.000 33.27100 ? 185 PHE A N   1 
ATOM   1356 C CA  . PHE A 1 183 ? -16.87393 3.53008   -37.73238 1.000 32.27050 ? 185 PHE A CA  1 
ATOM   1357 C C   . PHE A 1 183 ? -18.25339 4.13740   -37.48408 1.000 29.60395 ? 185 PHE A C   1 
ATOM   1358 O O   . PHE A 1 183 ? -18.44303 5.35589   -37.52076 1.000 27.47466 ? 185 PHE A O   1 
ATOM   1359 C CB  . PHE A 1 183 ? -16.23471 3.07502   -36.42859 1.000 34.26275 ? 185 PHE A CB  1 
ATOM   1360 C CG  . PHE A 1 183 ? -14.82626 2.59704   -36.60649 1.000 33.91814 ? 185 PHE A CG  1 
ATOM   1361 C CD1 . PHE A 1 183 ? -14.56804 1.41295   -37.28258 1.000 36.00116 ? 185 PHE A CD1 1 
ATOM   1362 C CD2 . PHE A 1 183 ? -13.76162 3.34566   -36.13810 1.000 33.84774 ? 185 PHE A CD2 1 
ATOM   1363 C CE1 . PHE A 1 183 ? -13.26604 0.97081   -37.46676 1.000 39.22433 ? 185 PHE A CE1 1 
ATOM   1364 C CE2 . PHE A 1 183 ? -12.46237 2.90382   -36.31277 1.000 32.08140 ? 185 PHE A CE2 1 
ATOM   1365 C CZ  . PHE A 1 183 ? -12.21855 1.71995   -36.97821 1.000 34.14980 ? 185 PHE A CZ  1 
ATOM   1366 N N   . VAL A 1 184 ? -19.23419 3.25784   -37.28315 1.000 32.22116 ? 186 VAL A N   1 
ATOM   1367 C CA  . VAL A 1 184 ? -20.61053 3.66948   -37.03684 1.000 29.67442 ? 186 VAL A CA  1 
ATOM   1368 C C   . VAL A 1 184 ? -21.16886 2.84217   -35.88471 1.000 29.63717 ? 186 VAL A C   1 
ATOM   1369 O O   . VAL A 1 184 ? -20.71860 1.72030   -35.62308 1.000 27.01553 ? 186 VAL A O   1 
ATOM   1370 C CB  . VAL A 1 184 ? -21.50244 3.51544   -38.28762 1.000 32.63728 ? 186 VAL A CB  1 
ATOM   1371 C CG1 . VAL A 1 184 ? -21.06873 4.49268   -39.37710 1.000 34.29288 ? 186 VAL A CG1 1 
ATOM   1372 C CG2 . VAL A 1 184 ? -21.45829 2.08008   -38.78535 1.000 31.69461 ? 186 VAL A CG2 1 
ATOM   1373 N N   . ASP A 1 185 ? -22.17651 3.40367   -35.19352 1.000 25.65303 ? 187 ASP A N   1 
ATOM   1374 C CA  . ASP A 1 185 ? -22.79286 2.67420   -34.08039 1.000 25.68806 ? 187 ASP A CA  1 
ATOM   1375 C C   . ASP A 1 185 ? -23.85372 1.73580   -34.64235 1.000 30.75557 ? 187 ASP A C   1 
ATOM   1376 O O   . ASP A 1 185 ? -25.06436 1.92710   -34.50535 1.000 30.50287 ? 187 ASP A O   1 
ATOM   1377 C CB  . ASP A 1 185 ? -23.34944 3.59147   -32.99190 1.000 26.86340 ? 187 ASP A CB  1 
ATOM   1378 C CG  . ASP A 1 185 ? -24.20549 4.75401   -33.49952 1.000 25.87457 ? 187 ASP A CG  1 
ATOM   1379 O OD1 . ASP A 1 185 ? -24.40788 4.99021   -34.71035 1.000 23.28679 ? 187 ASP A OD1 1 
ATOM   1380 O OD2 . ASP A 1 185 ? -24.65485 5.49200   -32.60370 1.000 22.98286 ? 187 ASP A OD2 1 
ATOM   1381 N N   . ARG A 1 186 ? -23.35623 0.65742   -35.22457 1.000 29.55305 ? 188 ARG A N   1 
ATOM   1382 C CA  . ARG A 1 186 ? -24.15114 -0.36695  -35.86246 1.000 32.70419 ? 188 ARG A CA  1 
ATOM   1383 C C   . ARG A 1 186 ? -23.32292 -1.63919  -35.79158 1.000 32.41793 ? 188 ARG A C   1 
ATOM   1384 O O   . ARG A 1 186 ? -22.09814 -1.59867  -35.95511 1.000 29.23458 ? 188 ARG A O   1 
ATOM   1385 C CB  . ARG A 1 186 ? -24.47025 0.07420   -37.29602 1.000 32.56173 ? 188 ARG A CB  1 
ATOM   1386 C CG  . ARG A 1 186 ? -25.41455 -0.76012  -38.05787 1.000 36.85590 ? 188 ARG A CG  1 
ATOM   1387 C CD  . ARG A 1 186 ? -25.53181 -0.24743  -39.49940 1.000 34.63106 ? 188 ARG A CD  1 
ATOM   1388 N NE  . ARG A 1 186 ? -26.08576 -1.29121  -40.35517 1.000 36.46404 ? 188 ARG A NE  1 
ATOM   1389 C CZ  . ARG A 1 186 ? -25.82530 -1.41941  -41.64822 1.000 34.25247 ? 188 ARG A CZ  1 
ATOM   1390 N NH1 . ARG A 1 186 ? -25.02126 -0.55251  -42.25576 1.000 29.85245 ? 188 ARG A NH1 1 
ATOM   1391 N NH2 . ARG A 1 186 ? -26.37608 -2.41181  -42.32590 1.000 29.54618 ? 188 ARG A NH2 1 
ATOM   1392 N N   . GLN A 1 187 ? -23.96263 -2.75204  -35.47810 1.000 27.93510 ? 189 GLN A N   1 
ATOM   1393 C CA  . GLN A 1 187 ? -23.23896 -4.02213  -35.48833 1.000 34.98963 ? 189 GLN A CA  1 
ATOM   1394 C C   . GLN A 1 187 ? -23.11571 -4.47664  -36.94309 1.000 38.65902 ? 189 GLN A C   1 
ATOM   1395 O O   . GLN A 1 187 ? -23.95252 -5.20444  -37.46622 1.000 40.74369 ? 189 GLN A O   1 
ATOM   1396 C CB  . GLN A 1 187 ? -23.93912 -5.06318  -34.62259 1.000 37.38303 ? 189 GLN A CB  1 
ATOM   1397 C CG  . GLN A 1 187 ? -23.20408 -6.40608  -34.57604 1.000 43.57239 ? 189 GLN A CG  1 
ATOM   1398 C CD  . GLN A 1 187 ? -23.97901 -7.49939  -33.85736 1.000 52.21243 ? 189 GLN A CD  1 
ATOM   1399 O OE1 . GLN A 1 187 ? -24.68602 -7.24228  -32.87759 1.000 55.28649 ? 189 GLN A OE1 1 
ATOM   1400 N NE2 . GLN A 1 187 ? -23.83861 -8.73554  -34.33749 1.000 55.43062 ? 189 GLN A NE2 1 
ATOM   1401 N N   . THR A 1 188 ? -22.07090 -4.01544  -37.61823 1.000 41.12380 ? 190 THR A N   1 
ATOM   1402 C CA  . THR A 1 188 ? -21.77537 -4.42307  -38.98363 1.000 46.44677 ? 190 THR A CA  1 
ATOM   1403 C C   . THR A 1 188 ? -20.43500 -5.12799  -39.01273 1.000 45.91281 ? 190 THR A C   1 
ATOM   1404 O O   . THR A 1 188 ? -19.70383 -5.16156  -38.02281 1.000 46.43899 ? 190 THR A O   1 
ATOM   1405 C CB  . THR A 1 188 ? -21.69452 -3.23256  -39.95179 1.000 44.52409 ? 190 THR A CB  1 
ATOM   1406 O OG1 . THR A 1 188 ? -20.35908 -2.70703  -39.93274 1.000 53.19536 ? 190 THR A OG1 1 
ATOM   1407 C CG2 . THR A 1 188 ? -22.62921 -2.14443  -39.55540 1.000 42.44499 ? 190 THR A CG2 1 
ATOM   1408 N N   . ALA A 1 189 ? -20.10572 -5.65873  -40.18555 1.000 49.42779 ? 191 ALA A N   1 
ATOM   1409 C CA  . ALA A 1 189 ? -18.71465 -5.94486  -40.50976 1.000 47.78380 ? 191 ALA A CA  1 
ATOM   1410 C C   . ALA A 1 189 ? -18.01850 -4.60366  -40.67885 1.000 48.80514 ? 191 ALA A C   1 
ATOM   1411 O O   . ALA A 1 189 ? -18.18421 -3.91761  -41.68959 1.000 53.67098 ? 191 ALA A O   1 
ATOM   1412 C CB  . ALA A 1 189 ? -18.59852 -6.80119  -41.76767 1.000 45.05034 ? 191 ALA A CB  1 
ATOM   1413 N N   . GLN A 1 190 ? -17.29672 -4.19159  -39.65000 1.000 41.61222 ? 192 GLN A N   1 
ATOM   1414 C CA  . GLN A 1 190 ? -16.38485 -3.06562  -39.73172 1.000 46.98051 ? 192 GLN A CA  1 
ATOM   1415 C C   . GLN A 1 190 ? -15.17990 -3.48613  -38.91584 1.000 46.67266 ? 192 GLN A C   1 
ATOM   1416 O O   . GLN A 1 190 ? -15.33774 -4.09482  -37.85257 1.000 48.51922 ? 192 GLN A O   1 
ATOM   1417 C CB  . GLN A 1 190 ? -17.00403 -1.75960  -39.20321 1.000 43.10052 ? 192 GLN A CB  1 
ATOM   1418 C CG  . GLN A 1 190 ? -17.64653 -1.87204  -37.82665 1.000 41.06557 ? 192 GLN A CG  1 
ATOM   1419 C CD  . GLN A 1 190 ? -18.48607 -0.64394  -37.45122 1.000 41.73326 ? 192 GLN A CD  1 
ATOM   1420 O OE1 . GLN A 1 190 ? -18.29128 0.45311   -37.98158 1.000 36.64011 ? 192 GLN A OE1 1 
ATOM   1421 N NE2 . GLN A 1 190 ? -19.42614 -0.83460  -36.53200 1.000 36.79002 ? 192 GLN A NE2 1 
ATOM   1422 N N   . ALA A 1 191 ? -13.99088 -3.23735  -39.44421 1.000 48.17930 ? 193 ALA A N   1 
ATOM   1423 C CA  . ALA A 1 191 ? -12.77186 -3.69785  -38.79824 1.000 49.20469 ? 193 ALA A CA  1 
ATOM   1424 C C   . ALA A 1 191 ? -11.72970 -2.59213  -38.84891 1.000 46.62562 ? 193 ALA A C   1 
ATOM   1425 O O   . ALA A 1 191 ? -11.69137 -1.79018  -39.78796 1.000 43.37803 ? 193 ALA A O   1 
ATOM   1426 C CB  . ALA A 1 191 ? -12.23079 -4.97850  -39.45506 1.000 47.09712 ? 193 ALA A CB  1 
ATOM   1427 N N   . ALA A 1 192 ? -10.89662 -2.54387  -37.81303 1.000 48.35838 ? 194 ALA A N   1 
ATOM   1428 C CA  . ALA A 1 192 ? -9.81766  -1.56951  -37.78935 1.000 47.16425 ? 194 ALA A CA  1 
ATOM   1429 C C   . ALA A 1 192 ? -8.87688  -1.81103  -38.96475 1.000 48.19593 ? 194 ALA A C   1 
ATOM   1430 O O   . ALA A 1 192 ? -8.47080  -2.94729  -39.22552 1.000 48.08368 ? 194 ALA A O   1 
ATOM   1431 C CB  . ALA A 1 192 ? -9.05398  -1.65187  -36.46675 1.000 44.78958 ? 194 ALA A CB  1 
ATOM   1432 N N   . GLY A 1 193 ? -8.56990  -0.74575  -39.69895 1.000 48.52081 ? 195 GLY A N   1 
ATOM   1433 C CA  . GLY A 1 193 ? -7.50937  -0.80284  -40.68644 1.000 51.42060 ? 195 GLY A CA  1 
ATOM   1434 C C   . GLY A 1 193 ? -6.17530  -1.16660  -40.05625 1.000 44.93903 ? 195 GLY A C   1 
ATOM   1435 O O   . GLY A 1 193 ? -5.99843  -1.20044  -38.83740 1.000 44.03623 ? 195 GLY A O   1 
ATOM   1436 N N   . THR A 1 194 ? -5.21013  -1.46455  -40.92062 1.000 50.29418 ? 196 THR A N   1 
ATOM   1437 C CA  . THR A 1 194 ? -3.89511  -1.85658  -40.43144 1.000 46.55995 ? 196 THR A CA  1 
ATOM   1438 C C   . THR A 1 194 ? -3.29962  -0.74154  -39.57647 1.000 40.30275 ? 196 THR A C   1 
ATOM   1439 O O   . THR A 1 194 ? -3.24494  0.42332   -39.98873 1.000 43.82959 ? 196 THR A O   1 
ATOM   1440 C CB  . THR A 1 194 ? -2.97518  -2.20936  -41.60887 1.000 49.33260 ? 196 THR A CB  1 
ATOM   1441 O OG1 . THR A 1 194 ? -1.64593  -2.43685  -41.12625 1.000 53.24397 ? 196 THR A OG1 1 
ATOM   1442 C CG2 . THR A 1 194 ? -2.97014  -1.09410  -42.66697 1.000 47.88433 ? 196 THR A CG2 1 
ATOM   1443 N N   . ASP A 1 195 ? -2.89962  -1.08257  -38.35764 1.000 37.12609 ? 197 ASP A N   1 
ATOM   1444 C CA  . ASP A 1 195 ? -2.37550  -0.04350  -37.49213 1.000 37.00036 ? 197 ASP A CA  1 
ATOM   1445 C C   . ASP A 1 195 ? -0.91414  0.22056   -37.82587 1.000 39.25740 ? 197 ASP A C   1 
ATOM   1446 O O   . ASP A 1 195 ? -0.17564  -0.67274  -38.24912 1.000 39.15287 ? 197 ASP A O   1 
ATOM   1447 C CB  . ASP A 1 195 ? -2.50662  -0.40256  -36.01512 1.000 35.34962 ? 197 ASP A CB  1 
ATOM   1448 C CG  . ASP A 1 195 ? -2.39875  0.82839   -35.12070 1.000 34.79290 ? 197 ASP A CG  1 
ATOM   1449 O OD1 . ASP A 1 195 ? -2.72620  1.92723   -35.61679 1.000 39.46245 ? 197 ASP A OD1 1 
ATOM   1450 O OD2 . ASP A 1 195 ? -1.97207  0.72074   -33.95486 1.000 36.06282 ? 197 ASP A OD2 1 
ATOM   1451 N N   . THR A 1 196 ? -0.51353  1.46823   -37.65776 1.000 32.74558 ? 198 THR A N   1 
ATOM   1452 C CA  . THR A 1 196 ? 0.85500   1.87599   -37.91697 1.000 31.14641 ? 198 THR A CA  1 
ATOM   1453 C C   . THR A 1 196 ? 1.44273   2.44662   -36.63782 1.000 28.29748 ? 198 THR A C   1 
ATOM   1454 O O   . THR A 1 196 ? 0.71305   2.81912   -35.71257 1.000 25.40730 ? 198 THR A O   1 
ATOM   1455 C CB  . THR A 1 196 ? 0.90127   2.90196   -39.04745 1.000 32.14994 ? 198 THR A CB  1 
ATOM   1456 O OG1 . THR A 1 196 ? -0.14649  3.86010   -38.86033 1.000 32.11058 ? 198 THR A OG1 1 
ATOM   1457 C CG2 . THR A 1 196 ? 0.70375   2.21253   -40.39846 1.000 32.42872 ? 198 THR A CG2 1 
ATOM   1458 N N   . THR A 1 197 ? 2.77502   2.50583   -36.57714 1.000 26.47675 ? 199 THR A N   1 
ATOM   1459 C CA  . THR A 1 197 ? 3.42583   3.11960   -35.43230 1.000 24.79764 ? 199 THR A CA  1 
ATOM   1460 C C   . THR A 1 197 ? 3.44299   4.63105   -35.62958 1.000 23.77517 ? 199 THR A C   1 
ATOM   1461 O O   . THR A 1 197 ? 3.58261   5.11818   -36.75397 1.000 24.38721 ? 199 THR A O   1 
ATOM   1462 C CB  . THR A 1 197 ? 4.84640   2.55769   -35.26533 1.000 28.07193 ? 199 THR A CB  1 
ATOM   1463 O OG1 . THR A 1 197 ? 4.75521   1.14781   -35.02203 1.000 28.88287 ? 199 THR A OG1 1 
ATOM   1464 C CG2 . THR A 1 197 ? 5.56993   3.21459   -34.09277 1.000 27.06750 ? 199 THR A CG2 1 
ATOM   1465 N N   . ILE A 1 198 ? 3.27914   5.37100   -34.53359 1.000 25.08075 ? 200 ILE A N   1 
ATOM   1466 C CA  . ILE A 1 198 ? 3.22177   6.83025   -34.56878 1.000 24.64178 ? 200 ILE A CA  1 
ATOM   1467 C C   . ILE A 1 198 ? 4.63877   7.40489   -34.58106 1.000 22.55573 ? 200 ILE A C   1 
ATOM   1468 O O   . ILE A 1 198 ? 5.22605   7.66089   -33.52440 1.000 24.43894 ? 200 ILE A O   1 
ATOM   1469 C CB  . ILE A 1 198 ? 2.42392   7.38012   -33.37189 1.000 22.38133 ? 200 ILE A CB  1 
ATOM   1470 C CG1 . ILE A 1 198 ? 0.99721   6.79951   -33.37158 1.000 22.53233 ? 200 ILE A CG1 1 
ATOM   1471 C CG2 . ILE A 1 198 ? 2.35979   8.90019   -33.41863 1.000 21.71162 ? 200 ILE A CG2 1 
ATOM   1472 C CD1 . ILE A 1 198 ? 0.38761   6.78982   -32.00065 1.000 21.58734 ? 200 ILE A CD1 1 
ATOM   1473 N N   . THR A 1 199 ? 5.14981   7.66681   -35.78124 1.000 25.12299 ? 201 THR A N   1 
ATOM   1474 C CA  . THR A 1 199 ? 6.56764   7.95497   -35.98159 1.000 25.80411 ? 201 THR A CA  1 
ATOM   1475 C C   . THR A 1 199 ? 7.00091   9.20224   -35.22651 1.000 24.64620 ? 201 THR A C   1 
ATOM   1476 O O   . THR A 1 199 ? 8.03313   9.20042   -34.54769 1.000 24.82805 ? 201 THR A O   1 
ATOM   1477 C CB  . THR A 1 199 ? 6.84270   8.11692   -37.47687 1.000 25.54953 ? 201 THR A CB  1 
ATOM   1478 O OG1 . THR A 1 199 ? 6.38962   6.94923   -38.17739 1.000 23.92457 ? 201 THR A OG1 1 
ATOM   1479 C CG2 . THR A 1 199 ? 8.35188   8.34384   -37.73156 1.000 23.83850 ? 201 THR A CG2 1 
ATOM   1480 N N   . VAL A 1 200 ? 6.24008   10.29440  -35.35881 1.000 23.78145 ? 202 VAL A N   1 
ATOM   1481 C CA  . VAL A 1 200 ? 6.61247   11.52929  -34.67912 1.000 23.10197 ? 202 VAL A CA  1 
ATOM   1482 C C   . VAL A 1 200 ? 6.71834   11.32345  -33.17222 1.000 23.76898 ? 202 VAL A C   1 
ATOM   1483 O O   . VAL A 1 200 ? 7.54806   11.96193  -32.51137 1.000 25.08642 ? 202 VAL A O   1 
ATOM   1484 C CB  . VAL A 1 200 ? 5.63106   12.66783  -35.05040 1.000 25.30006 ? 202 VAL A CB  1 
ATOM   1485 C CG1 . VAL A 1 200 ? 4.21905   12.43477  -34.45312 1.000 27.39993 ? 202 VAL A CG1 1 
ATOM   1486 C CG2 . VAL A 1 200 ? 6.19328   14.00984  -34.61832 1.000 29.40268 ? 202 VAL A CG2 1 
ATOM   1487 N N   . ASN A 1 201 ? 5.91034   10.42084  -32.60060 1.000 23.78664 ? 203 ASN A N   1 
ATOM   1488 C CA  . ASN A 1 201 ? 5.98364   10.19395  -31.15726 1.000 24.32277 ? 203 ASN A CA  1 
ATOM   1489 C C   . ASN A 1 201 ? 7.22982   9.39484   -30.77605 1.000 22.91353 ? 203 ASN A C   1 
ATOM   1490 O O   . ASN A 1 201 ? 7.84384   9.65815   -29.73210 1.000 24.03453 ? 203 ASN A O   1 
ATOM   1491 C CB  . ASN A 1 201 ? 4.72578   9.47455   -30.65968 1.000 22.10107 ? 203 ASN A CB  1 
ATOM   1492 C CG  . ASN A 1 201 ? 3.49346   10.39406  -30.58780 1.000 25.09622 ? 203 ASN A CG  1 
ATOM   1493 O OD1 . ASN A 1 201 ? 3.53535   11.56063  -30.98070 1.000 23.53515 ? 203 ASN A OD1 1 
ATOM   1494 N ND2 . ASN A 1 201 ? 2.38153   9.84760   -30.08409 1.000 23.86203 ? 203 ASN A ND2 1 
ATOM   1495 N N   . VAL A 1 202 ? 7.60704   8.40372   -31.58548 1.000 23.00806 ? 204 VAL A N   1 
ATOM   1496 C CA  . VAL A 1 202 ? 8.85912   7.67992   -31.33115 1.000 25.50822 ? 204 VAL A CA  1 
ATOM   1497 C C   . VAL A 1 202 ? 10.04457  8.63865   -31.34748 1.000 23.58924 ? 204 VAL A C   1 
ATOM   1498 O O   . VAL A 1 202 ? 10.92442  8.57533   -30.48246 1.000 22.92439 ? 204 VAL A O   1 
ATOM   1499 C CB  . VAL A 1 202 ? 9.05944   6.54387   -32.34910 1.000 22.06172 ? 204 VAL A CB  1 
ATOM   1500 C CG1 . VAL A 1 202 ? 10.40718  5.84912   -32.10852 1.000 22.96994 ? 204 VAL A CG1 1 
ATOM   1501 C CG2 . VAL A 1 202 ? 7.89976   5.52364   -32.28934 1.000 22.46868 ? 204 VAL A CG2 1 
ATOM   1502 N N   . LEU A 1 203 ? 10.08967  9.53292   -32.34217 1.000 24.19557 ? 205 LEU A N   1 
ATOM   1503 C CA  . LEU A 1 203 ? 11.19277  10.48559  -32.43624 1.000 26.70051 ? 205 LEU A CA  1 
ATOM   1504 C C   . LEU A 1 203 ? 11.21636  11.42322  -31.23435 1.000 28.78283 ? 205 LEU A C   1 
ATOM   1505 O O   . LEU A 1 203 ? 12.28423  11.70947  -30.68185 1.000 23.44507 ? 205 LEU A O   1 
ATOM   1506 C CB  . LEU A 1 203 ? 11.09811  11.27919  -33.74053 1.000 20.97628 ? 205 LEU A CB  1 
ATOM   1507 C CG  . LEU A 1 203 ? 11.39851  10.54522  -35.04428 1.000 26.58212 ? 205 LEU A CG  1 
ATOM   1508 C CD1 . LEU A 1 203 ? 10.92493  11.36642  -36.21643 1.000 26.15176 ? 205 LEU A CD1 1 
ATOM   1509 C CD2 . LEU A 1 203 ? 12.91062  10.23357  -35.20390 1.000 21.90956 ? 205 LEU A CD2 1 
ATOM   1510 N N   . ALA A 1 204 ? 10.04557  11.89491  -30.79705 1.000 27.90864 ? 206 ALA A N   1 
ATOM   1511 C CA  . ALA A 1 204 ? 9.99370   12.73628  -29.60326 1.000 25.09410 ? 206 ALA A CA  1 
ATOM   1512 C C   . ALA A 1 204 ? 10.56074  12.00204  -28.39491 1.000 25.90187 ? 206 ALA A C   1 
ATOM   1513 O O   . ALA A 1 204 ? 11.28226  12.58735  -27.57930 1.000 29.20121 ? 206 ALA A O   1 
ATOM   1514 C CB  . ALA A 1 204 ? 8.55006   13.17736  -29.33552 1.000 24.96107 ? 206 ALA A CB  1 
ATOM   1515 N N   . TRP A 1 205 ? 10.25663  10.71093  -28.27407 1.000 24.34462 ? 207 TRP A N   1 
ATOM   1516 C CA  . TRP A 1 205 ? 10.72553  9.92326   -27.13599 1.000 23.46467 ? 207 TRP A CA  1 
ATOM   1517 C C   . TRP A 1 205 ? 12.22902  9.62304   -27.23507 1.000 25.37382 ? 207 TRP A C   1 
ATOM   1518 O O   . TRP A 1 205 ? 12.93679  9.60362   -26.21620 1.000 24.08988 ? 207 TRP A O   1 
ATOM   1519 C CB  . TRP A 1 205 ? 9.87117   8.65725   -27.07463 1.000 26.65865 ? 207 TRP A CB  1 
ATOM   1520 C CG  . TRP A 1 205 ? 10.24478  7.58009   -26.11879 1.000 28.16520 ? 207 TRP A CG  1 
ATOM   1521 C CD1 . TRP A 1 205 ? 9.94227   7.50442   -24.77427 1.000 30.11993 ? 207 TRP A CD1 1 
ATOM   1522 C CD2 . TRP A 1 205 ? 10.90577  6.36207   -26.45107 1.000 26.60969 ? 207 TRP A CD2 1 
ATOM   1523 N NE1 . TRP A 1 205 ? 10.42117  6.32071   -24.25982 1.000 31.38909 ? 207 TRP A NE1 1 
ATOM   1524 C CE2 . TRP A 1 205 ? 11.01379  5.60455   -25.26779 1.000 32.71621 ? 207 TRP A CE2 1 
ATOM   1525 C CE3 . TRP A 1 205 ? 11.44219  5.84685   -27.63730 1.000 30.87339 ? 207 TRP A CE3 1 
ATOM   1526 C CZ2 . TRP A 1 205 ? 11.64363  4.36105   -25.23578 1.000 33.65455 ? 207 TRP A CZ2 1 
ATOM   1527 C CZ3 . TRP A 1 205 ? 12.05590  4.60442   -27.60474 1.000 34.22283 ? 207 TRP A CZ3 1 
ATOM   1528 C CH2 . TRP A 1 205 ? 12.15222  3.87987   -26.41372 1.000 29.82537 ? 207 TRP A CH2 1 
ATOM   1529 N N   . LEU A 1 206 ? 12.74753  9.41349   -28.44877 1.000 23.52030 ? 208 LEU A N   1 
ATOM   1530 C CA  . LEU A 1 206 ? 14.20682  9.30582   -28.59558 1.000 25.32442 ? 208 LEU A CA  1 
ATOM   1531 C C   . LEU A 1 206 ? 14.90119  10.60134  -28.16099 1.000 27.50270 ? 208 LEU A C   1 
ATOM   1532 O O   . LEU A 1 206 ? 15.95124  10.56411  -27.50210 1.000 28.83616 ? 208 LEU A O   1 
ATOM   1533 C CB  . LEU A 1 206 ? 14.57559  8.95076   -30.03959 1.000 25.45563 ? 208 LEU A CB  1 
ATOM   1534 C CG  . LEU A 1 206 ? 14.20156  7.53556   -30.50582 1.000 26.86285 ? 208 LEU A CG  1 
ATOM   1535 C CD1 . LEU A 1 206 ? 14.49011  7.35332   -32.00725 1.000 23.34668 ? 208 LEU A CD1 1 
ATOM   1536 C CD2 . LEU A 1 206 ? 14.91314  6.45817   -29.67947 1.000 27.97426 ? 208 LEU A CD2 1 
ATOM   1537 N N   . TYR A 1 207 ? 14.31538  11.76068  -28.49838 1.000 29.14184 ? 209 TYR A N   1 
ATOM   1538 C CA  . TYR A 1 207 ? 14.81504  13.03360  -27.96860 1.000 30.80536 ? 209 TYR A CA  1 
ATOM   1539 C C   . TYR A 1 207 ? 14.76460  13.06632  -26.44577 1.000 30.93699 ? 209 TYR A C   1 
ATOM   1540 O O   . TYR A 1 207 ? 15.69535  13.55942  -25.80234 1.000 31.89237 ? 209 TYR A O   1 
ATOM   1541 C CB  . TYR A 1 207 ? 14.02067  14.20672  -28.54598 1.000 28.10024 ? 209 TYR A CB  1 
ATOM   1542 C CG  . TYR A 1 207 ? 14.54284  14.66579  -29.88373 1.000 31.63657 ? 209 TYR A CG  1 
ATOM   1543 C CD1 . TYR A 1 207 ? 15.79576  15.27048  -29.99823 1.000 28.86160 ? 209 TYR A CD1 1 
ATOM   1544 C CD2 . TYR A 1 207 ? 13.80902  14.45625  -31.03563 1.000 25.57094 ? 209 TYR A CD2 1 
ATOM   1545 C CE1 . TYR A 1 207 ? 16.26408  15.67710  -31.21801 1.000 29.57999 ? 209 TYR A CE1 1 
ATOM   1546 C CE2 . TYR A 1 207 ? 14.26618  14.85277  -32.25282 1.000 29.54824 ? 209 TYR A CE2 1 
ATOM   1547 C CZ  . TYR A 1 207 ? 15.49989  15.46408  -32.34609 1.000 34.69501 ? 209 TYR A CZ  1 
ATOM   1548 O OH  . TYR A 1 207 ? 15.94438  15.85722  -33.57566 1.000 32.30630 ? 209 TYR A OH  1 
ATOM   1549 N N   . ALA A 1 208 ? 13.67914  12.56464  -25.84522 1.000 27.99520 ? 210 ALA A N   1 
ATOM   1550 C CA  . ALA A 1 208 ? 13.63781  12.50269  -24.38945 1.000 31.15249 ? 210 ALA A CA  1 
ATOM   1551 C C   . ALA A 1 208 ? 14.74944  11.60645  -23.84607 1.000 32.55464 ? 210 ALA A C   1 
ATOM   1552 O O   . ALA A 1 208 ? 15.32905  11.89552  -22.79541 1.000 34.09880 ? 210 ALA A O   1 
ATOM   1553 C CB  . ALA A 1 208 ? 12.26657  12.01958  -23.90939 1.000 32.81326 ? 210 ALA A CB  1 
ATOM   1554 N N   . ALA A 1 209 ? 15.06435  10.51672  -24.54779 1.000 29.20749 ? 211 ALA A N   1 
ATOM   1555 C CA  . ALA A 1 209 ? 16.14411  9.64602   -24.09618 1.000 30.21918 ? 211 ALA A CA  1 
ATOM   1556 C C   . ALA A 1 209 ? 17.48490  10.37782  -24.11464 1.000 32.12630 ? 211 ALA A C   1 
ATOM   1557 O O   . ALA A 1 209 ? 18.27601  10.26244  -23.17040 1.000 34.54147 ? 211 ALA A O   1 
ATOM   1558 C CB  . ALA A 1 209 ? 16.19682  8.39085   -24.96599 1.000 30.60978 ? 211 ALA A CB  1 
ATOM   1559 N N   . VAL A 1 210 ? 17.74929  11.14419  -25.17624 1.000 30.27724 ? 212 VAL A N   1 
ATOM   1560 C CA  . VAL A 1 210 ? 18.99939  11.89494  -25.26826 1.000 33.15557 ? 212 VAL A CA  1 
ATOM   1561 C C   . VAL A 1 210 ? 19.08336  12.91633  -24.13757 1.000 38.61603 ? 212 VAL A C   1 
ATOM   1562 O O   . VAL A 1 210 ? 20.10585  13.02452  -23.44982 1.000 35.05215 ? 212 VAL A O   1 
ATOM   1563 C CB  . VAL A 1 210 ? 19.11706  12.56082  -26.65094 1.000 31.36132 ? 212 VAL A CB  1 
ATOM   1564 C CG1 . VAL A 1 210 ? 20.32318  13.48556  -26.71625 1.000 32.70612 ? 212 VAL A CG1 1 
ATOM   1565 C CG2 . VAL A 1 210 ? 19.19838  11.51377  -27.73589 1.000 28.04650 ? 212 VAL A CG2 1 
ATOM   1566 N N   . ILE A 1 211 ? 17.99125  13.65826  -23.91452 1.000 32.42496 ? 213 ILE A N   1 
ATOM   1567 C CA  . ILE A 1 211 ? 17.91831  14.64320  -22.83190 1.000 38.00819 ? 213 ILE A CA  1 
ATOM   1568 C C   . ILE A 1 211 ? 18.20405  13.99839  -21.47668 1.000 39.26914 ? 213 ILE A C   1 
ATOM   1569 O O   . ILE A 1 211 ? 18.82948  14.61075  -20.59961 1.000 39.71980 ? 213 ILE A O   1 
ATOM   1570 C CB  . ILE A 1 211 ? 16.54020  15.33980  -22.84826 1.000 34.22783 ? 213 ILE A CB  1 
ATOM   1571 C CG1 . ILE A 1 211 ? 16.43927  16.27683  -24.04937 1.000 37.47829 ? 213 ILE A CG1 1 
ATOM   1572 C CG2 . ILE A 1 211 ? 16.28937  16.11056  -21.55996 1.000 37.15721 ? 213 ILE A CG2 1 
ATOM   1573 C CD1 . ILE A 1 211 ? 15.00102  16.58651  -24.47542 1.000 36.62924 ? 213 ILE A CD1 1 
ATOM   1574 N N   . ASN A 1 212 ? 17.75216  12.76458  -21.27193 1.000 38.41765 ? 214 ASN A N   1 
ATOM   1575 C CA  . ASN A 1 212 ? 18.01868  12.08064  -20.01262 1.000 39.56428 ? 214 ASN A CA  1 
ATOM   1576 C C   . ASN A 1 212 ? 19.29469  11.25243  -20.03233 1.000 39.78619 ? 214 ASN A C   1 
ATOM   1577 O O   . ASN A 1 212 ? 19.48278  10.42159  -19.13811 1.000 45.78151 ? 214 ASN A O   1 
ATOM   1578 C CB  . ASN A 1 212 ? 16.84329  11.19123  -19.62857 1.000 39.50114 ? 214 ASN A CB  1 
ATOM   1579 C CG  . ASN A 1 212 ? 15.64839  11.99331  -19.18313 1.000 49.27037 ? 214 ASN A CG  1 
ATOM   1580 O OD1 . ASN A 1 212 ? 15.47782  12.26673  -17.99242 1.000 54.92574 ? 214 ASN A OD1 1 
ATOM   1581 N ND2 . ASN A 1 212 ? 14.82162  12.40513  -20.14080 1.000 45.92301 ? 214 ASN A ND2 1 
ATOM   1582 N N   . GLY A 1 213 ? 20.15984  11.43627  -21.02541 1.000 36.44960 ? 215 GLY A N   1 
ATOM   1583 C CA  . GLY A 1 213 ? 21.48731  10.85510  -20.98265 1.000 39.83524 ? 215 GLY A CA  1 
ATOM   1584 C C   . GLY A 1 213 ? 21.70517  9.55387   -21.73159 1.000 44.59154 ? 215 GLY A C   1 
ATOM   1585 O O   . GLY A 1 213 ? 22.79302  8.98226   -21.61637 1.000 43.92079 ? 215 GLY A O   1 
ATOM   1586 N N   . ASP A 1 214 ? 20.72128  9.05989   -22.48596 1.000 34.08655 ? 216 ASP A N   1 
ATOM   1587 C CA  . ASP A 1 214 ? 20.94021  7.91443   -23.36646 1.000 36.12463 ? 216 ASP A CA  1 
ATOM   1588 C C   . ASP A 1 214 ? 21.41579  8.40787   -24.72551 1.000 41.49957 ? 216 ASP A C   1 
ATOM   1589 O O   . ASP A 1 214 ? 20.87086  9.37463   -25.26460 1.000 41.01102 ? 216 ASP A O   1 
ATOM   1590 C CB  . ASP A 1 214 ? 19.67224  7.08117   -23.54253 1.000 39.55347 ? 216 ASP A CB  1 
ATOM   1591 C CG  . ASP A 1 214 ? 19.34595  6.25571   -22.32469 1.000 46.15162 ? 216 ASP A CG  1 
ATOM   1592 O OD1 . ASP A 1 214 ? 20.12127  6.32918   -21.34526 1.000 49.91735 ? 216 ASP A OD1 1 
ATOM   1593 O OD2 . ASP A 1 214 ? 18.31172  5.54147   -22.34101 1.000 46.94763 ? 216 ASP A OD2 1 
ATOM   1594 N N   . ARG A 1 215 ? 22.43391  7.74801   -25.27639 1.000 33.82794 ? 217 ARG A N   1 
ATOM   1595 C CA  . ARG A 1 215 ? 22.95949  8.13592   -26.57789 1.000 34.75003 ? 217 ARG A CA  1 
ATOM   1596 C C   . ARG A 1 215 ? 23.38959  6.95379   -27.43110 1.000 29.33105 ? 217 ARG A C   1 
ATOM   1597 O O   . ARG A 1 215 ? 23.79631  7.16853   -28.57794 1.000 31.68814 ? 217 ARG A O   1 
ATOM   1598 C CB  . ARG A 1 215 ? 24.15177  9.09494   -26.41305 1.000 38.92582 ? 217 ARG A CB  1 
ATOM   1599 C CG  . ARG A 1 215 ? 23.77446  10.48140  -25.91413 1.000 41.60903 ? 217 ARG A CG  1 
ATOM   1600 C CD  . ARG A 1 215 ? 24.95824  11.40794  -25.87741 1.000 38.91805 ? 217 ARG A CD  1 
ATOM   1601 N NE  . ARG A 1 215 ? 25.57785  11.53276  -27.19387 1.000 45.41441 ? 217 ARG A NE  1 
ATOM   1602 C CZ  . ARG A 1 215 ? 25.40908  12.56905  -28.01463 1.000 41.18662 ? 217 ARG A CZ  1 
ATOM   1603 N NH1 . ARG A 1 215 ? 26.01896  12.58311  -29.19382 1.000 36.29564 ? 217 ARG A NH1 1 
ATOM   1604 N NH2 . ARG A 1 215 ? 24.63650  13.59069  -27.66090 1.000 37.35859 ? 217 ARG A NH2 1 
ATOM   1605 N N   . TRP A 1 216 ? 23.29841  5.72070   -26.91624 1.000 28.35937 ? 218 TRP A N   1 
ATOM   1606 C CA  . TRP A 1 216 ? 23.91511  4.56981   -27.56928 1.000 26.47490 ? 218 TRP A CA  1 
ATOM   1607 C C   . TRP A 1 216 ? 23.37739  4.34253   -28.97115 1.000 28.79468 ? 218 TRP A C   1 
ATOM   1608 O O   . TRP A 1 216 ? 24.08119  3.77575   -29.81445 1.000 24.75786 ? 218 TRP A O   1 
ATOM   1609 C CB  . TRP A 1 216 ? 23.72786  3.30597   -26.71342 1.000 28.82833 ? 218 TRP A CB  1 
ATOM   1610 C CG  . TRP A 1 216 ? 22.28997  2.82196   -26.52278 1.000 31.38698 ? 218 TRP A CG  1 
ATOM   1611 C CD1 . TRP A 1 216 ? 21.48859  3.03711   -25.43111 1.000 30.10221 ? 218 TRP A CD1 1 
ATOM   1612 C CD2 . TRP A 1 216 ? 21.52031  2.01501   -27.42679 1.000 28.75751 ? 218 TRP A CD2 1 
ATOM   1613 N NE1 . TRP A 1 216 ? 20.26702  2.42522   -25.60797 1.000 30.44015 ? 218 TRP A NE1 1 
ATOM   1614 C CE2 . TRP A 1 216 ? 20.26006  1.79140   -26.82162 1.000 31.20044 ? 218 TRP A CE2 1 
ATOM   1615 C CE3 . TRP A 1 216 ? 21.77228  1.45849   -28.68556 1.000 31.41555 ? 218 TRP A CE3 1 
ATOM   1616 C CZ2 . TRP A 1 216 ? 19.25419  1.04016   -27.43741 1.000 31.91452 ? 218 TRP A CZ2 1 
ATOM   1617 C CZ3 . TRP A 1 216 ? 20.76905  0.71370   -29.30098 1.000 31.64445 ? 218 TRP A CZ3 1 
ATOM   1618 C CH2 . TRP A 1 216 ? 19.52109  0.51594   -28.67492 1.000 35.34310 ? 218 TRP A CH2 1 
ATOM   1619 N N   . PHE A 1 217 ? 22.14434  4.78013   -29.24565 1.000 26.54830 ? 219 PHE A N   1 
ATOM   1620 C CA  . PHE A 1 217 ? 21.48864  4.51785   -30.52136 1.000 24.53381 ? 219 PHE A CA  1 
ATOM   1621 C C   . PHE A 1 217 ? 21.77602  5.57132   -31.58873 1.000 25.48669 ? 219 PHE A C   1 
ATOM   1622 O O   . PHE A 1 217 ? 21.34998  5.39250   -32.74028 1.000 27.54882 ? 219 PHE A O   1 
ATOM   1623 C CB  . PHE A 1 217 ? 19.96244  4.42385   -30.30211 1.000 25.55004 ? 219 PHE A CB  1 
ATOM   1624 C CG  . PHE A 1 217 ? 19.41927  5.55153   -29.48206 1.000 24.56014 ? 219 PHE A CG  1 
ATOM   1625 C CD1 . PHE A 1 217 ? 19.12382  6.76732   -30.07203 1.000 25.59954 ? 219 PHE A CD1 1 
ATOM   1626 C CD2 . PHE A 1 217 ? 19.21651  5.40183   -28.11855 1.000 29.22286 ? 219 PHE A CD2 1 
ATOM   1627 C CE1 . PHE A 1 217 ? 18.65042  7.83038   -29.30700 1.000 26.79987 ? 219 PHE A CE1 1 
ATOM   1628 C CE2 . PHE A 1 217 ? 18.72408  6.45133   -27.35125 1.000 27.79218 ? 219 PHE A CE2 1 
ATOM   1629 C CZ  . PHE A 1 217 ? 18.44683  7.66313   -27.93779 1.000 28.74948 ? 219 PHE A CZ  1 
ATOM   1630 N N   . LEU A 1 218 ? 22.45484  6.66526   -31.24066 1.000 26.13587 ? 220 LEU A N   1 
ATOM   1631 C CA  . LEU A 1 218 ? 22.83274  7.68330   -32.21726 1.000 28.88139 ? 220 LEU A CA  1 
ATOM   1632 C C   . LEU A 1 218 ? 23.88446  7.14486   -33.19353 1.000 32.51052 ? 220 LEU A C   1 
ATOM   1633 O O   . LEU A 1 218 ? 24.61753  6.19869   -32.89568 1.000 25.79458 ? 220 LEU A O   1 
ATOM   1634 C CB  . LEU A 1 218 ? 23.37067  8.92618   -31.51510 1.000 27.17901 ? 220 LEU A CB  1 
ATOM   1635 C CG  . LEU A 1 218 ? 22.42800  9.58612   -30.50511 1.000 32.00123 ? 220 LEU A CG  1 
ATOM   1636 C CD1 . LEU A 1 218 ? 23.12937  10.72721  -29.79996 1.000 33.87260 ? 220 LEU A CD1 1 
ATOM   1637 C CD2 . LEU A 1 218 ? 21.12768  10.06194  -31.18668 1.000 33.05490 ? 220 LEU A CD2 1 
ATOM   1638 N N   . ASN A 1 219 ? 23.94630  7.74739   -34.38093 1.000 32.26107 ? 221 ASN A N   1 
ATOM   1639 C CA  . ASN A 1 219 ? 24.97922  7.36370   -35.34830 1.000 30.27846 ? 221 ASN A CA  1 
ATOM   1640 C C   . ASN A 1 219 ? 25.44844  8.61211   -36.08820 1.000 32.13190 ? 221 ASN A C   1 
ATOM   1641 O O   . ASN A 1 219 ? 25.04332  9.73636   -35.77414 1.000 30.69149 ? 221 ASN A O   1 
ATOM   1642 C CB  . ASN A 1 219 ? 24.47814  6.25741   -36.28997 1.000 24.90047 ? 221 ASN A CB  1 
ATOM   1643 C CG  . ASN A 1 219 ? 23.30687  6.69706   -37.18134 1.000 29.64127 ? 221 ASN A CG  1 
ATOM   1644 O OD1 . ASN A 1 219 ? 23.17943  7.86104   -37.55736 1.000 28.28373 ? 221 ASN A OD1 1 
ATOM   1645 N ND2 . ASN A 1 219 ? 22.47313  5.73733   -37.55493 1.000 34.90118 ? 221 ASN A ND2 1 
ATOM   1646 N N   . ARG A 1 220 ? 26.31675  8.41490   -37.08658 1.000 30.70673 ? 222 ARG A N   1 
ATOM   1647 C CA  . ARG A 1 220 ? 26.92744  9.52692   -37.79895 1.000 31.30456 ? 222 ARG A CA  1 
ATOM   1648 C C   . ARG A 1 220 ? 26.19728  9.85093   -39.09701 1.000 32.37864 ? 222 ARG A C   1 
ATOM   1649 O O   . ARG A 1 220 ? 26.68686  10.66022  -39.88775 1.000 33.46502 ? 222 ARG A O   1 
ATOM   1650 C CB  . ARG A 1 220 ? 28.40600  9.23232   -38.08060 1.000 31.81883 ? 222 ARG A CB  1 
ATOM   1651 C CG  . ARG A 1 220 ? 29.34236  9.53829   -36.88129 1.000 40.20041 ? 222 ARG A CG  1 
ATOM   1652 C CD  . ARG A 1 220 ? 29.91548  10.96445  -36.91338 1.000 45.99481 ? 222 ARG A CD  1 
ATOM   1653 N NE  . ARG A 1 220 ? 30.53635  11.26092  -38.20826 1.000 53.24438 ? 222 ARG A NE  1 
ATOM   1654 C CZ  . ARG A 1 220 ? 31.16125  12.39673  -38.52083 1.000 57.13860 ? 222 ARG A CZ  1 
ATOM   1655 N NH1 . ARG A 1 220 ? 31.25498  13.38415  -37.63662 1.000 56.60184 ? 222 ARG A NH1 1 
ATOM   1656 N NH2 . ARG A 1 220 ? 31.68109  12.55520  -39.73749 1.000 63.41847 ? 222 ARG A NH2 1 
ATOM   1657 N N   . PHE A 1 221 ? 25.02797  9.25738   -39.32559 1.000 29.38059 ? 223 PHE A N   1 
ATOM   1658 C CA  . PHE A 1 221 ? 24.30225  9.42418   -40.57806 1.000 27.63701 ? 223 PHE A CA  1 
ATOM   1659 C C   . PHE A 1 221 ? 23.18774  10.45947  -40.46728 1.000 30.80151 ? 223 PHE A C   1 
ATOM   1660 O O   . PHE A 1 221 ? 22.70441  10.80124  -39.38569 1.000 29.66660 ? 223 PHE A O   1 
ATOM   1661 C CB  . PHE A 1 221 ? 23.70385  8.08829   -41.04373 1.000 29.29687 ? 223 PHE A CB  1 
ATOM   1662 C CG  . PHE A 1 221 ? 24.73254  7.09402   -41.49403 1.000 33.93733 ? 223 PHE A CG  1 
ATOM   1663 C CD1 . PHE A 1 221 ? 25.75077  7.47623   -42.35294 1.000 41.29855 ? 223 PHE A CD1 1 
ATOM   1664 C CD2 . PHE A 1 221 ? 24.70708  5.79136   -41.04042 1.000 37.81309 ? 223 PHE A CD2 1 
ATOM   1665 C CE1 . PHE A 1 221 ? 26.71167  6.56299   -42.76437 1.000 40.98390 ? 223 PHE A CE1 1 
ATOM   1666 C CE2 . PHE A 1 221 ? 25.67203  4.87600   -41.45379 1.000 37.07015 ? 223 PHE A CE2 1 
ATOM   1667 C CZ  . PHE A 1 221 ? 26.65632  5.25935   -42.31881 1.000 35.08456 ? 223 PHE A CZ  1 
ATOM   1668 N N   . THR A 1 222 ? 22.78263  10.95349  -41.62173 1.000 29.72609 ? 224 THR A N   1 
ATOM   1669 C CA  . THR A 1 222 ? 21.57508  11.73028  -41.75516 1.000 29.66459 ? 224 THR A CA  1 
ATOM   1670 C C   . THR A 1 222 ? 20.73645  11.08920  -42.84431 1.000 29.57441 ? 224 THR A C   1 
ATOM   1671 O O   . THR A 1 222 ? 21.07396  10.02874  -43.37364 1.000 30.41911 ? 224 THR A O   1 
ATOM   1672 C CB  . THR A 1 222 ? 21.88551  13.19596  -42.05962 1.000 34.40175 ? 224 THR A CB  1 
ATOM   1673 O OG1 . THR A 1 222 ? 20.68542  13.97340  -41.91178 1.000 39.19093 ? 224 THR A OG1 1 
ATOM   1674 C CG2 . THR A 1 222 ? 22.43803  13.35179  -43.48372 1.000 38.23077 ? 224 THR A CG2 1 
ATOM   1675 N N   . THR A 1 223 ? 19.62390  11.73154  -43.17308 1.000 31.04003 ? 225 THR A N   1 
ATOM   1676 C CA  . THR A 1 223 ? 18.76182  11.19167  -44.20338 1.000 29.34410 ? 225 THR A CA  1 
ATOM   1677 C C   . THR A 1 223 ? 17.97793  12.34449  -44.80544 1.000 31.50062 ? 225 THR A C   1 
ATOM   1678 O O   . THR A 1 223 ? 17.79806  13.38647  -44.16886 1.000 31.73728 ? 225 THR A O   1 
ATOM   1679 C CB  . THR A 1 223 ? 17.83073  10.10134  -43.63312 1.000 31.96907 ? 225 THR A CB  1 
ATOM   1680 O OG1 . THR A 1 223 ? 16.96697  9.59063   -44.65558 1.000 29.10199 ? 225 THR A OG1 1 
ATOM   1681 C CG2 . THR A 1 223 ? 16.97400  10.65138  -42.48916 1.000 30.64023 ? 225 THR A CG2 1 
ATOM   1682 N N   . THR A 1 224 ? 17.55950  12.17489  -46.05481 1.000 34.40422 ? 226 THR A N   1 
ATOM   1683 C CA  . THR A 1 224 ? 16.51531  13.05178  -46.55342 1.000 32.74069 ? 226 THR A CA  1 
ATOM   1684 C C   . THR A 1 224 ? 15.17530  12.60293  -45.98253 1.000 33.01316 ? 226 THR A C   1 
ATOM   1685 O O   . THR A 1 224 ? 14.99786  11.44385  -45.58027 1.000 30.03639 ? 226 THR A O   1 
ATOM   1686 C CB  . THR A 1 224 ? 16.46134  13.04627  -48.07609 1.000 30.14672 ? 226 THR A CB  1 
ATOM   1687 O OG1 . THR A 1 224 ? 15.97262  11.77961  -48.52086 1.000 31.12351 ? 226 THR A OG1 1 
ATOM   1688 C CG2 . THR A 1 224 ? 17.85471  13.29881  -48.66537 1.000 32.92323 ? 226 THR A CG2 1 
ATOM   1689 N N   . LEU A 1 225 ? 14.22994  13.54864  -45.92938 1.000 35.41520 ? 227 LEU A N   1 
ATOM   1690 C CA  . LEU A 1 225 ? 12.88428  13.22065  -45.46361 1.000 29.72484 ? 227 LEU A CA  1 
ATOM   1691 C C   . LEU A 1 225 ? 12.28079  12.12078  -46.31293 1.000 29.31066 ? 227 LEU A C   1 
ATOM   1692 O O   . LEU A 1 225 ? 11.66537  11.18136  -45.78896 1.000 30.38928 ? 227 LEU A O   1 
ATOM   1693 C CB  . LEU A 1 225 ? 11.99241  14.46524  -45.49186 1.000 28.83053 ? 227 LEU A CB  1 
ATOM   1694 C CG  . LEU A 1 225 ? 10.65687  14.33664  -44.74918 1.000 32.79081 ? 227 LEU A CG  1 
ATOM   1695 C CD1 . LEU A 1 225 ? 10.88475  13.88234  -43.32926 1.000 31.47995 ? 227 LEU A CD1 1 
ATOM   1696 C CD2 . LEU A 1 225 ? 9.90038   15.65006  -44.76068 1.000 40.16608 ? 227 LEU A CD2 1 
ATOM   1697 N N   . ASN A 1 226 ? 12.46303  12.20066  -47.63148 1.000 30.56432 ? 228 ASN A N   1 
ATOM   1698 C CA  . ASN A 1 226 ? 11.82310  11.20735  -48.48236 1.000 31.21973 ? 228 ASN A CA  1 
ATOM   1699 C C   . ASN A 1 226 ? 12.44021  9.82842   -48.29729 1.000 31.47599 ? 228 ASN A C   1 
ATOM   1700 O O   . ASN A 1 226 ? 11.71964  8.82557   -48.25805 1.000 25.66872 ? 228 ASN A O   1 
ATOM   1701 C CB  . ASN A 1 226 ? 11.88861  11.61282  -49.94795 1.000 35.66024 ? 228 ASN A CB  1 
ATOM   1702 C CG  . ASN A 1 226 ? 10.91431  10.82452  -50.77951 1.000 41.95971 ? 228 ASN A CG  1 
ATOM   1703 O OD1 . ASN A 1 226 ? 9.69849   10.99520  -50.64527 1.000 48.28828 ? 228 ASN A OD1 1 
ATOM   1704 N ND2 . ASN A 1 226 ? 11.42583  9.91652   -51.59963 1.000 37.48356 ? 228 ASN A ND2 1 
ATOM   1705 N N   . ASP A 1 227 ? 13.77312  9.74718   -48.20296 1.000 29.72563 ? 229 ASP A N   1 
ATOM   1706 C CA  . ASP A 1 227 ? 14.39476  8.44675   -47.96445 1.000 28.83219 ? 229 ASP A CA  1 
ATOM   1707 C C   . ASP A 1 227 ? 13.95213  7.84997   -46.62499 1.000 25.84875 ? 229 ASP A C   1 
ATOM   1708 O O   . ASP A 1 227 ? 13.75263  6.63374   -46.51187 1.000 27.81969 ? 229 ASP A O   1 
ATOM   1709 C CB  . ASP A 1 227 ? 15.92150  8.57225   -48.01956 1.000 28.46740 ? 229 ASP A CB  1 
ATOM   1710 C CG  . ASP A 1 227 ? 16.45973  8.54572   -49.45246 1.000 32.78217 ? 229 ASP A CG  1 
ATOM   1711 O OD1 . ASP A 1 227 ? 15.68750  8.22890   -50.38541 1.000 30.59095 ? 229 ASP A OD1 1 
ATOM   1712 O OD2 . ASP A 1 227 ? 17.65708  8.84846   -49.64251 1.000 35.38742 ? 229 ASP A OD2 1 
ATOM   1713 N N   . PHE A 1 228 ? 13.82593  8.67812   -45.59287 1.000 26.69166 ? 230 PHE A N   1 
ATOM   1714 C CA  . PHE A 1 228 ? 13.32838  8.16847   -44.31565 1.000 27.30237 ? 230 PHE A CA  1 
ATOM   1715 C C   . PHE A 1 228 ? 11.93863  7.55330   -44.47256 1.000 29.09464 ? 230 PHE A C   1 
ATOM   1716 O O   . PHE A 1 228 ? 11.68919  6.42242   -44.03031 1.000 26.59997 ? 230 PHE A O   1 
ATOM   1717 C CB  . PHE A 1 228 ? 13.29262  9.28123   -43.26960 1.000 27.06419 ? 230 PHE A CB  1 
ATOM   1718 C CG  . PHE A 1 228 ? 12.60457  8.86924   -41.99584 1.000 28.53083 ? 230 PHE A CG  1 
ATOM   1719 C CD1 . PHE A 1 228 ? 13.28878  8.13721   -41.04441 1.000 29.04509 ? 230 PHE A CD1 1 
ATOM   1720 C CD2 . PHE A 1 228 ? 11.26397  9.17494   -41.77218 1.000 32.02277 ? 230 PHE A CD2 1 
ATOM   1721 C CE1 . PHE A 1 228 ? 12.67009  7.73185   -39.87847 1.000 30.32582 ? 230 PHE A CE1 1 
ATOM   1722 C CE2 . PHE A 1 228 ? 10.63212  8.76865   -40.60905 1.000 29.51635 ? 230 PHE A CE2 1 
ATOM   1723 C CZ  . PHE A 1 228 ? 11.33693  8.04687   -39.65999 1.000 31.34313 ? 230 PHE A CZ  1 
ATOM   1724 N N   . ASN A 1 229 ? 11.01151  8.29142   -45.09569 1.000 29.90749 ? 231 ASN A N   1 
ATOM   1725 C CA  . ASN A 1 229 ? 9.64930   7.78633   -45.21607 1.000 29.33139 ? 231 ASN A CA  1 
ATOM   1726 C C   . ASN A 1 229 ? 9.61128   6.52346   -46.06393 1.000 31.10923 ? 231 ASN A C   1 
ATOM   1727 O O   . ASN A 1 229 ? 8.84157   5.60467   -45.77959 1.000 29.84591 ? 231 ASN A O   1 
ATOM   1728 C CB  . ASN A 1 229 ? 8.72908   8.86665   -45.79288 1.000 32.42537 ? 231 ASN A CB  1 
ATOM   1729 C CG  . ASN A 1 229 ? 8.43890   9.97450   -44.79303 1.000 33.25591 ? 231 ASN A CG  1 
ATOM   1730 O OD1 . ASN A 1 229 ? 8.32226   9.72657   -43.59001 1.000 34.80780 ? 231 ASN A OD1 1 
ATOM   1731 N ND2 . ASN A 1 229 ? 8.32167   11.20146  -45.28328 1.000 34.49674 ? 231 ASN A ND2 1 
ATOM   1732 N N   . LEU A 1 230 ? 10.46494  6.43555   -47.09071 1.000 29.18615 ? 232 LEU A N   1 
ATOM   1733 C CA  . LEU A 1 230 ? 10.49664  5.21114   -47.88598 1.000 27.87306 ? 232 LEU A CA  1 
ATOM   1734 C C   . LEU A 1 230 ? 10.90079  4.01254   -47.04257 1.000 26.13414 ? 232 LEU A C   1 
ATOM   1735 O O   . LEU A 1 230 ? 10.39518  2.90768   -47.24193 1.000 27.21523 ? 232 LEU A O   1 
ATOM   1736 C CB  . LEU A 1 230 ? 11.45003  5.36583   -49.07032 1.000 28.00705 ? 232 LEU A CB  1 
ATOM   1737 C CG  . LEU A 1 230 ? 10.91561  6.12417   -50.27958 1.000 29.32632 ? 232 LEU A CG  1 
ATOM   1738 C CD1 . LEU A 1 230 ? 12.03177  6.32139   -51.30080 1.000 34.90544 ? 232 LEU A CD1 1 
ATOM   1739 C CD2 . LEU A 1 230 ? 9.74034   5.38622   -50.90060 1.000 31.89686 ? 232 LEU A CD2 1 
ATOM   1740 N N   . VAL A 1 231 ? 11.84740  4.19745   -46.12583 1.000 26.68142 ? 233 VAL A N   1 
ATOM   1741 C CA  . VAL A 1 231 ? 12.27097  3.09157   -45.27610 1.000 29.59101 ? 233 VAL A CA  1 
ATOM   1742 C C   . VAL A 1 231 ? 11.24886  2.84158   -44.17464 1.000 27.67286 ? 233 VAL A C   1 
ATOM   1743 O O   . VAL A 1 231 ? 10.85374  1.69882   -43.91546 1.000 27.62051 ? 233 VAL A O   1 
ATOM   1744 C CB  . VAL A 1 231 ? 13.66365  3.37430   -44.68874 1.000 26.06177 ? 233 VAL A CB  1 
ATOM   1745 C CG1 . VAL A 1 231 ? 14.02512  2.34174   -43.62246 1.000 30.21409 ? 233 VAL A CG1 1 
ATOM   1746 C CG2 . VAL A 1 231 ? 14.72307  3.37360   -45.79480 1.000 26.66349 ? 233 VAL A CG2 1 
ATOM   1747 N N   . ALA A 1 232 ? 10.82648  3.90660   -43.49876 1.000 30.20021 ? 234 ALA A N   1 
ATOM   1748 C CA  . ALA A 1 232 ? 9.94654   3.73912   -42.34630 1.000 30.83616 ? 234 ALA A CA  1 
ATOM   1749 C C   . ALA A 1 232 ? 8.63517   3.06928   -42.74394 1.000 29.54267 ? 234 ALA A C   1 
ATOM   1750 O O   . ALA A 1 232 ? 8.09114   2.25736   -41.98971 1.000 31.55475 ? 234 ALA A O   1 
ATOM   1751 C CB  . ALA A 1 232 ? 9.69264   5.09317   -41.68187 1.000 29.58419 ? 234 ALA A CB  1 
ATOM   1752 N N   . MET A 1 233 ? 8.13232   3.35548   -43.93994 1.000 30.46948 ? 235 MET A N   1 
ATOM   1753 C CA  . MET A 1 233 ? 6.87916   2.71965   -44.33461 1.000 30.76214 ? 235 MET A CA  1 
ATOM   1754 C C   . MET A 1 233 ? 7.02861   1.21895   -44.52462 1.000 30.62221 ? 235 MET A C   1 
ATOM   1755 O O   . MET A 1 233 ? 6.03930   0.48704   -44.40970 1.000 27.22146 ? 235 MET A O   1 
ATOM   1756 C CB  . MET A 1 233 ? 6.33882   3.38717   -45.58776 1.000 30.49516 ? 235 MET A CB  1 
ATOM   1757 C CG  . MET A 1 233 ? 5.87565   4.80089   -45.25817 1.000 42.88476 ? 235 MET A CG  1 
ATOM   1758 S SD  . MET A 1 233 ? 5.08540   5.67001   -46.60664 1.000 52.37421 ? 235 MET A SD  1 
ATOM   1759 C CE  . MET A 1 233 ? 3.46852   4.88439   -46.60100 1.000 47.73189 ? 235 MET A CE  1 
ATOM   1760 N N   . LYS A 1 234 ? 8.24955   0.73441   -44.75115 1.000 28.40234 ? 236 LYS A N   1 
ATOM   1761 C CA  . LYS A 1 234 ? 8.45900   -0.70071  -44.82453 1.000 27.59461 ? 236 LYS A CA  1 
ATOM   1762 C C   . LYS A 1 234 ? 8.36831   -1.38295  -43.46724 1.000 24.77029 ? 236 LYS A C   1 
ATOM   1763 O O   . LYS A 1 234 ? 8.31432   -2.61620  -43.41907 1.000 28.36625 ? 236 LYS A O   1 
ATOM   1764 C CB  . LYS A 1 234 ? 9.81167   -0.98191  -45.49380 1.000 31.47618 ? 236 LYS A CB  1 
ATOM   1765 C CG  . LYS A 1 234 ? 9.78424   -0.71016  -47.00256 1.000 32.35953 ? 236 LYS A CG  1 
ATOM   1766 C CD  . LYS A 1 234 ? 11.19462  -0.54351  -47.59830 1.000 38.70263 ? 236 LYS A CD  1 
ATOM   1767 C CE  . LYS A 1 234 ? 11.12363  -0.17008  -49.07614 1.000 39.10482 ? 236 LYS A CE  1 
ATOM   1768 N NZ  . LYS A 1 234 ? 12.48754  -0.00249  -49.65858 1.000 38.93499 ? 236 LYS A NZ  1 
ATOM   1769 N N   . TYR A 1 235 ? 8.34398   -0.62723  -42.36772 1.000 29.48456 ? 237 TYR A N   1 
ATOM   1770 C CA  . TYR A 1 235 ? 8.13859   -1.18857  -41.03514 1.000 27.12883 ? 237 TYR A CA  1 
ATOM   1771 C C   . TYR A 1 235 ? 6.75848   -0.86992  -40.47070 1.000 33.16226 ? 237 TYR A C   1 
ATOM   1772 O O   . TYR A 1 235 ? 6.54734   -1.03687  -39.26171 1.000 30.04665 ? 237 TYR A O   1 
ATOM   1773 C CB  . TYR A 1 235 ? 9.19814   -0.67750  -40.05458 1.000 27.53299 ? 237 TYR A CB  1 
ATOM   1774 C CG  . TYR A 1 235 ? 10.61975  -1.07620  -40.39860 1.000 27.85618 ? 237 TYR A CG  1 
ATOM   1775 C CD1 . TYR A 1 235 ? 11.16869  -2.25537  -39.91515 1.000 30.58636 ? 237 TYR A CD1 1 
ATOM   1776 C CD2 . TYR A 1 235 ? 11.41327  -0.25594  -41.19509 1.000 28.67875 ? 237 TYR A CD2 1 
ATOM   1777 C CE1 . TYR A 1 235 ? 12.49101  -2.62216  -40.22451 1.000 30.19319 ? 237 TYR A CE1 1 
ATOM   1778 C CE2 . TYR A 1 235 ? 12.72841  -0.60848  -41.51378 1.000 28.88514 ? 237 TYR A CE2 1 
ATOM   1779 C CZ  . TYR A 1 235 ? 13.25440  -1.79159  -41.03018 1.000 30.31455 ? 237 TYR A CZ  1 
ATOM   1780 O OH  . TYR A 1 235 ? 14.55361  -2.12011  -41.34687 1.000 28.38292 ? 237 TYR A OH  1 
ATOM   1781 N N   . ASN A 1 236 ? 5.82666   -0.40135  -41.30728 1.000 30.47211 ? 238 ASN A N   1 
ATOM   1782 C CA  . ASN A 1 236 ? 4.49402   0.02797   -40.85617 1.000 33.13444 ? 238 ASN A CA  1 
ATOM   1783 C C   . ASN A 1 236 ? 4.59396   1.19100   -39.87379 1.000 33.41245 ? 238 ASN A C   1 
ATOM   1784 O O   . ASN A 1 236 ? 3.90639   1.23069   -38.84929 1.000 31.17121 ? 238 ASN A O   1 
ATOM   1785 C CB  . ASN A 1 236 ? 3.70259   -1.13023  -40.24878 1.000 34.22492 ? 238 ASN A CB  1 
ATOM   1786 C CG  . ASN A 1 236 ? 3.22328   -2.12039  -41.29716 1.000 44.20045 ? 238 ASN A CG  1 
ATOM   1787 O OD1 . ASN A 1 236 ? 3.18890   -1.81034  -42.48981 1.000 41.83571 ? 238 ASN A OD1 1 
ATOM   1788 N ND2 . ASN A 1 236 ? 2.84014   -3.31701  -40.85493 1.000 50.63887 ? 238 ASN A ND2 1 
ATOM   1789 N N   . TYR A 1 237 ? 5.48377   2.12937   -40.17972 1.000 30.21405 ? 239 TYR A N   1 
ATOM   1790 C CA  . TYR A 1 237 ? 5.57230   3.40447   -39.48738 1.000 29.65389 ? 239 TYR A CA  1 
ATOM   1791 C C   . TYR A 1 237 ? 4.80825   4.45635   -40.28427 1.000 30.01255 ? 239 TYR A C   1 
ATOM   1792 O O   . TYR A 1 237 ? 4.83016   4.44279   -41.51879 1.000 31.41097 ? 239 TYR A O   1 
ATOM   1793 C CB  . TYR A 1 237 ? 7.03740   3.82977   -39.32371 1.000 26.96933 ? 239 TYR A CB  1 
ATOM   1794 C CG  . TYR A 1 237 ? 7.63869   3.38578   -38.01253 1.000 23.13024 ? 239 TYR A CG  1 
ATOM   1795 C CD1 . TYR A 1 237 ? 7.73478   2.04124   -37.69209 1.000 24.29093 ? 239 TYR A CD1 1 
ATOM   1796 C CD2 . TYR A 1 237 ? 8.07774   4.31847   -37.07700 1.000 28.67346 ? 239 TYR A CD2 1 
ATOM   1797 C CE1 . TYR A 1 237 ? 8.26567   1.62645   -36.48635 1.000 23.18871 ? 239 TYR A CE1 1 
ATOM   1798 C CE2 . TYR A 1 237 ? 8.60858   3.91273   -35.85862 1.000 26.70319 ? 239 TYR A CE2 1 
ATOM   1799 C CZ  . TYR A 1 237 ? 8.69411   2.56757   -35.57387 1.000 25.59620 ? 239 TYR A CZ  1 
ATOM   1800 O OH  . TYR A 1 237 ? 9.22612   2.15924   -34.36900 1.000 25.72638 ? 239 TYR A OH  1 
ATOM   1801 N N   . GLU A 1 238 ? 4.13683   5.36518   -39.57641 1.000 27.78950 ? 240 GLU A N   1 
ATOM   1802 C CA  . GLU A 1 238 ? 3.47224   6.48267   -40.23504 1.000 32.52652 ? 240 GLU A CA  1 
ATOM   1803 C C   . GLU A 1 238 ? 4.50332   7.36012   -40.93949 1.000 32.40842 ? 240 GLU A C   1 
ATOM   1804 O O   . GLU A 1 238 ? 5.62254   7.52765   -40.45088 1.000 32.94922 ? 240 GLU A O   1 
ATOM   1805 C CB  . GLU A 1 238 ? 2.69988   7.33676   -39.22675 1.000 31.68081 ? 240 GLU A CB  1 
ATOM   1806 C CG  . GLU A 1 238 ? 1.36314   6.77734   -38.80090 1.000 31.67263 ? 240 GLU A CG  1 
ATOM   1807 C CD  . GLU A 1 238 ? 0.33874   6.79767   -39.91764 1.000 40.42566 ? 240 GLU A CD  1 
ATOM   1808 O OE1 . GLU A 1 238 ? -0.06812  5.70009   -40.37734 1.000 38.30038 ? 240 GLU A OE1 1 
ATOM   1809 O OE2 . GLU A 1 238 ? -0.05891  7.91205   -40.33243 1.000 42.03276 ? 240 GLU A OE2 1 
ATOM   1810 N N   . PRO A 1 239 ? 4.15357   7.94555   -42.07961 1.000 34.54891 ? 241 PRO A N   1 
ATOM   1811 C CA  . PRO A 1 239 ? 5.07744   8.88216   -42.72047 1.000 35.53305 ? 241 PRO A CA  1 
ATOM   1812 C C   . PRO A 1 239 ? 5.23889   10.14938  -41.90130 1.000 36.84738 ? 241 PRO A C   1 
ATOM   1813 O O   . PRO A 1 239 ? 4.31079   10.62976  -41.24139 1.000 32.52261 ? 241 PRO A O   1 
ATOM   1814 C CB  . PRO A 1 239 ? 4.41751   9.17314   -44.07506 1.000 40.68580 ? 241 PRO A CB  1 
ATOM   1815 C CG  . PRO A 1 239 ? 3.01273   8.75968   -43.92269 1.000 37.49914 ? 241 PRO A CG  1 
ATOM   1816 C CD  . PRO A 1 239 ? 3.00071   7.63425   -42.94207 1.000 35.54352 ? 241 PRO A CD  1 
ATOM   1817 N N   . LEU A 1 240 ? 6.44419   10.68795  -41.95954 1.000 30.29953 ? 242 LEU A N   1 
ATOM   1818 C CA  . LEU A 1 240 ? 6.79528   11.91160  -41.26312 1.000 33.93433 ? 242 LEU A CA  1 
ATOM   1819 C C   . LEU A 1 240 ? 6.61059   13.08950  -42.21140 1.000 37.89037 ? 242 LEU A C   1 
ATOM   1820 O O   . LEU A 1 240 ? 7.11174   13.06115  -43.33897 1.000 33.97806 ? 242 LEU A O   1 
ATOM   1821 C CB  . LEU A 1 240 ? 8.24097   11.82587  -40.76655 1.000 31.61251 ? 242 LEU A CB  1 
ATOM   1822 C CG  . LEU A 1 240 ? 8.65283   12.73862  -39.62140 1.000 34.91229 ? 242 LEU A CG  1 
ATOM   1823 C CD1 . LEU A 1 240 ? 8.00699   12.31041  -38.28464 1.000 33.86145 ? 242 LEU A CD1 1 
ATOM   1824 C CD2 . LEU A 1 240 ? 10.19622  12.78506  -39.52464 1.000 33.88360 ? 242 LEU A CD2 1 
ATOM   1825 N N   . THR A 1 241 ? 5.86888   14.10707  -41.76239 1.000 37.21587 ? 243 THR A N   1 
ATOM   1826 C CA  . THR A 1 241 ? 5.57780   15.29077  -42.55860 1.000 36.90160 ? 243 THR A CA  1 
ATOM   1827 C C   . THR A 1 241 ? 6.46838   16.45531  -42.14512 1.000 39.96987 ? 243 THR A C   1 
ATOM   1828 O O   . THR A 1 241 ? 7.10216   16.44967  -41.08766 1.000 38.54872 ? 243 THR A O   1 
ATOM   1829 C CB  . THR A 1 241 ? 4.10591   15.70031  -42.40335 1.000 40.44186 ? 243 THR A CB  1 
ATOM   1830 O OG1 . THR A 1 241 ? 3.86911   16.09728  -41.04385 1.000 36.06920 ? 243 THR A OG1 1 
ATOM   1831 C CG2 . THR A 1 241 ? 3.20006   14.55471  -42.75252 1.000 33.12193 ? 243 THR A CG2 1 
ATOM   1832 N N   . GLN A 1 242 ? 6.49808   17.48173  -42.99665 1.000 37.72674 ? 244 GLN A N   1 
ATOM   1833 C CA  . GLN A 1 242 ? 7.21759   18.69533  -42.63145 1.000 43.36989 ? 244 GLN A CA  1 
ATOM   1834 C C   . GLN A 1 242 ? 6.61992   19.33986  -41.38763 1.000 39.21511 ? 244 GLN A C   1 
ATOM   1835 O O   . GLN A 1 242 ? 7.34145   19.98417  -40.61581 1.000 42.02165 ? 244 GLN A O   1 
ATOM   1836 C CB  . GLN A 1 242 ? 7.22533   19.67890  -43.80275 1.000 46.12384 ? 244 GLN A CB  1 
ATOM   1837 C CG  . GLN A 1 242 ? 8.01005   20.95047  -43.53425 1.000 45.74131 ? 244 GLN A CG  1 
ATOM   1838 C CD  . GLN A 1 242 ? 9.44918   20.67196  -43.16585 1.000 48.69155 ? 244 GLN A CD  1 
ATOM   1839 O OE1 . GLN A 1 242 ? 10.11145  19.83518  -43.78664 1.000 45.26953 ? 244 GLN A OE1 1 
ATOM   1840 N NE2 . GLN A 1 242 ? 9.94377   21.36702  -42.14521 1.000 47.27880 ? 244 GLN A NE2 1 
ATOM   1841 N N   . ASP A 1 243 ? 5.31027   19.17266  -41.17229 1.000 42.12411 ? 245 ASP A N   1 
ATOM   1842 C CA  . ASP A 1 243 ? 4.70140   19.60545  -39.91796 1.000 46.00750 ? 245 ASP A CA  1 
ATOM   1843 C C   . ASP A 1 243 ? 5.33118   18.88794  -38.73412 1.000 38.57624 ? 245 ASP A C   1 
ATOM   1844 O O   . ASP A 1 243 ? 5.63575   19.50609  -37.70812 1.000 41.84397 ? 245 ASP A O   1 
ATOM   1845 C CB  . ASP A 1 243 ? 3.19272   19.34445  -39.93584 1.000 46.13269 ? 245 ASP A CB  1 
ATOM   1846 C CG  . ASP A 1 243 ? 2.41562   20.40656  -40.68312 1.000 55.68179 ? 245 ASP A CG  1 
ATOM   1847 O OD1 . ASP A 1 243 ? 2.86040   20.83179  -41.77526 1.000 55.09698 ? 245 ASP A OD1 1 
ATOM   1848 O OD2 . ASP A 1 243 ? 1.34025   20.79853  -40.17142 1.000 60.19143 ? 245 ASP A OD2 1 
ATOM   1849 N N   . HIS A 1 244 ? 5.50379   17.56802  -38.85154 1.000 38.71239 ? 246 HIS A N   1 
ATOM   1850 C CA  . HIS A 1 244 ? 6.15306   16.80012  -37.79145 1.000 38.17475 ? 246 HIS A CA  1 
ATOM   1851 C C   . HIS A 1 244 ? 7.57963   17.28485  -37.54265 1.000 36.63713 ? 246 HIS A C   1 
ATOM   1852 O O   . HIS A 1 244 ? 7.99840   17.43658  -36.39050 1.000 35.38802 ? 246 HIS A O   1 
ATOM   1853 C CB  . HIS A 1 244 ? 6.14381   15.31905  -38.15377 1.000 34.05563 ? 246 HIS A CB  1 
ATOM   1854 C CG  . HIS A 1 244 ? 4.77710   14.71450  -38.18994 1.000 36.20350 ? 246 HIS A CG  1 
ATOM   1855 N ND1 . HIS A 1 244 ? 4.43640   13.70478  -39.06111 1.000 36.52357 ? 246 HIS A ND1 1 
ATOM   1856 C CD2 . HIS A 1 244 ? 3.66709   14.96565  -37.45233 1.000 34.34675 ? 246 HIS A CD2 1 
ATOM   1857 C CE1 . HIS A 1 244 ? 3.17538   13.36243  -38.86323 1.000 38.44994 ? 246 HIS A CE1 1 
ATOM   1858 N NE2 . HIS A 1 244 ? 2.68848   14.11014  -37.89013 1.000 35.87750 ? 246 HIS A NE2 1 
ATOM   1859 N N   . VAL A 1 245 ? 8.33736   17.54352  -38.61084 1.000 38.63592 ? 247 VAL A N   1 
ATOM   1860 C CA  . VAL A 1 245 ? 9.70001   18.05402  -38.45516 1.000 38.17333 ? 247 VAL A CA  1 
ATOM   1861 C C   . VAL A 1 245 ? 9.69240   19.38140  -37.70075 1.000 41.96228 ? 247 VAL A C   1 
ATOM   1862 O O   . VAL A 1 245 ? 10.49494  19.60139  -36.77907 1.000 36.57100 ? 247 VAL A O   1 
ATOM   1863 C CB  . VAL A 1 245 ? 10.37524  18.19560  -39.83006 1.000 41.16740 ? 247 VAL A CB  1 
ATOM   1864 C CG1 . VAL A 1 245 ? 11.73151  18.88787  -39.69031 1.000 37.64120 ? 247 VAL A CG1 1 
ATOM   1865 C CG2 . VAL A 1 245 ? 10.52108  16.82995  -40.48941 1.000 37.84109 ? 247 VAL A CG2 1 
ATOM   1866 N N   . ASP A 1 246 ? 8.78977   20.29007  -38.09465 1.000 41.54321 ? 248 ASP A N   1 
ATOM   1867 C CA  . ASP A 1 246 ? 8.64113   21.56901  -37.40350 1.000 42.83471 ? 248 ASP A CA  1 
ATOM   1868 C C   . ASP A 1 246 ? 8.33248   21.35678  -35.92787 1.000 38.60346 ? 248 ASP A C   1 
ATOM   1869 O O   . ASP A 1 246 ? 8.92555   21.99865  -35.05070 1.000 39.87361 ? 248 ASP A O   1 
ATOM   1870 C CB  . ASP A 1 246 ? 7.52309   22.38974  -38.05658 1.000 45.49411 ? 248 ASP A CB  1 
ATOM   1871 C CG  . ASP A 1 246 ? 7.92281   22.99163  -39.39659 1.000 49.72194 ? 248 ASP A CG  1 
ATOM   1872 O OD1 . ASP A 1 246 ? 9.08144   22.81197  -39.83946 1.000 51.51471 ? 248 ASP A OD1 1 
ATOM   1873 O OD2 . ASP A 1 246 ? 7.05520   23.64794  -40.01286 1.000 54.03310 ? 248 ASP A OD2 1 
ATOM   1874 N N   . ILE A 1 247 ? 7.39925   20.45267  -35.63740 1.000 36.50856 ? 249 ILE A N   1 
ATOM   1875 C CA  . ILE A 1 247 ? 7.01600   20.19326  -34.25621 1.000 38.08351 ? 249 ILE A CA  1 
ATOM   1876 C C   . ILE A 1 247 ? 8.20300   19.70023  -33.43217 1.000 38.10719 ? 249 ILE A C   1 
ATOM   1877 O O   . ILE A 1 247 ? 8.33295   20.03905  -32.24892 1.000 36.49130 ? 249 ILE A O   1 
ATOM   1878 C CB  . ILE A 1 247 ? 5.83812   19.20354  -34.23878 1.000 38.75173 ? 249 ILE A CB  1 
ATOM   1879 C CG1 . ILE A 1 247 ? 4.56107   19.91195  -34.70647 1.000 41.98712 ? 249 ILE A CG1 1 
ATOM   1880 C CG2 . ILE A 1 247 ? 5.63381   18.63472  -32.85099 1.000 39.23876 ? 249 ILE A CG2 1 
ATOM   1881 C CD1 . ILE A 1 247 ? 3.40598   18.97096  -35.04148 1.000 39.50239 ? 249 ILE A CD1 1 
ATOM   1882 N N   . LEU A 1 248 ? 9.09945   18.92443  -34.03476 1.000 36.35060 ? 250 LEU A N   1 
ATOM   1883 C CA  . LEU A 1 248 ? 10.25615  18.42333  -33.29657 1.000 36.29746 ? 250 LEU A CA  1 
ATOM   1884 C C   . LEU A 1 248 ? 11.34627  19.46842  -33.10455 1.000 40.01508 ? 250 LEU A C   1 
ATOM   1885 O O   . LEU A 1 248 ? 12.33596  19.18467  -32.41669 1.000 40.26317 ? 250 LEU A O   1 
ATOM   1886 C CB  . LEU A 1 248 ? 10.83545  17.19856  -34.00574 1.000 33.94256 ? 250 LEU A CB  1 
ATOM   1887 C CG  . LEU A 1 248 ? 9.90010   15.98810  -34.01344 1.000 34.45310 ? 250 LEU A CG  1 
ATOM   1888 C CD1 . LEU A 1 248 ? 10.34788  14.96410  -35.05658 1.000 32.91615 ? 250 LEU A CD1 1 
ATOM   1889 C CD2 . LEU A 1 248 ? 9.79482   15.36213  -32.61623 1.000 30.13091 ? 250 LEU A CD2 1 
ATOM   1890 N N   . GLY A 1 249 ? 11.18705  20.66131  -33.67850 1.000 40.08726 ? 251 GLY A N   1 
ATOM   1891 C CA  . GLY A 1 249 ? 12.20621  21.68826  -33.64661 1.000 39.57716 ? 251 GLY A CA  1 
ATOM   1892 C C   . GLY A 1 249 ? 12.76288  22.01420  -32.27435 1.000 42.34992 ? 251 GLY A C   1 
ATOM   1893 O O   . GLY A 1 249 ? 13.98249  21.99353  -32.06127 1.000 40.97612 ? 251 GLY A O   1 
ATOM   1894 N N   . PRO A 1 250 ? 11.88477  22.34552  -31.31810 1.000 39.98728 ? 252 PRO A N   1 
ATOM   1895 C CA  . PRO A 1 250 ? 12.37081  22.65782  -29.96018 1.000 41.76945 ? 252 PRO A CA  1 
ATOM   1896 C C   . PRO A 1 250 ? 13.26551  21.58793  -29.34923 1.000 42.08058 ? 252 PRO A C   1 
ATOM   1897 O O   . PRO A 1 250 ? 14.27772  21.92256  -28.71849 1.000 40.88708 ? 252 PRO A O   1 
ATOM   1898 C CB  . PRO A 1 250 ? 11.06757  22.82872  -29.17004 1.000 39.75205 ? 252 PRO A CB  1 
ATOM   1899 C CG  . PRO A 1 250 ? 10.13144  23.39215  -30.16176 1.000 40.95215 ? 252 PRO A CG  1 
ATOM   1900 C CD  . PRO A 1 250 ? 10.46815  22.72545  -31.48278 1.000 42.59440 ? 252 PRO A CD  1 
ATOM   1901 N N   . LEU A 1 251 ? 12.91255  20.30953  -29.50869 1.000 41.68313 ? 253 LEU A N   1 
ATOM   1902 C CA  . LEU A 1 251 ? 13.74118  19.23706  -28.96738 1.000 37.18946 ? 253 LEU A CA  1 
ATOM   1903 C C   . LEU A 1 251 ? 15.03580  19.08394  -29.75251 1.000 37.73922 ? 253 LEU A C   1 
ATOM   1904 O O   . LEU A 1 251 ? 16.06926  18.72062  -29.17895 1.000 35.82315 ? 253 LEU A O   1 
ATOM   1905 C CB  . LEU A 1 251 ? 12.95816  17.92487  -28.97165 1.000 35.77940 ? 253 LEU A CB  1 
ATOM   1906 C CG  . LEU A 1 251 ? 11.75309  17.89955  -28.03584 1.000 35.60571 ? 253 LEU A CG  1 
ATOM   1907 C CD1 . LEU A 1 251 ? 10.81930  16.76951  -28.43593 1.000 32.02174 ? 253 LEU A CD1 1 
ATOM   1908 C CD2 . LEU A 1 251 ? 12.21813  17.75337  -26.59503 1.000 31.87756 ? 253 LEU A CD2 1 
ATOM   1909 N N   . SER A 1 252 ? 14.99579  19.34784  -31.05769 1.000 40.39250 ? 254 SER A N   1 
ATOM   1910 C CA  . SER A 1 252 ? 16.22323  19.37779  -31.84535 1.000 38.96426 ? 254 SER A CA  1 
ATOM   1911 C C   . SER A 1 252 ? 17.17765  20.44239  -31.31819 1.000 42.15695 ? 254 SER A C   1 
ATOM   1912 O O   . SER A 1 252 ? 18.36326  20.17410  -31.09025 1.000 42.61456 ? 254 SER A O   1 
ATOM   1913 C CB  . SER A 1 252 ? 15.88753  19.62043  -33.31633 1.000 38.58194 ? 254 SER A CB  1 
ATOM   1914 O OG  . SER A 1 252 ? 17.05093  19.52458  -34.12029 1.000 42.40599 ? 254 SER A OG  1 
ATOM   1915 N N   . ALA A 1 253 ? 16.66775  21.65753  -31.09637 1.000 44.64393 ? 255 ALA A N   1 
ATOM   1916 C CA  . ALA A 1 253 ? 17.51102  22.74225  -30.59993 1.000 45.71366 ? 255 ALA A CA  1 
ATOM   1917 C C   . ALA A 1 253 ? 18.02155  22.44345  -29.19948 1.000 44.11435 ? 255 ALA A C   1 
ATOM   1918 O O   . ALA A 1 253 ? 19.17745  22.74019  -28.87465 1.000 43.92251 ? 255 ALA A O   1 
ATOM   1919 C CB  . ALA A 1 253 ? 16.73537  24.06035  -30.61724 1.000 45.24880 ? 255 ALA A CB  1 
ATOM   1920 N N   . GLN A 1 254 ? 17.17679  21.84234  -28.35944 1.000 45.16728 ? 256 GLN A N   1 
ATOM   1921 C CA  . GLN A 1 254 ? 17.59181  21.51871  -27.00057 1.000 43.33949 ? 256 GLN A CA  1 
ATOM   1922 C C   . GLN A 1 254 ? 18.74863  20.52685  -26.99276 1.000 45.19287 ? 256 GLN A C   1 
ATOM   1923 O O   . GLN A 1 254 ? 19.69296  20.67186  -26.20685 1.000 44.34787 ? 256 GLN A O   1 
ATOM   1924 C CB  . GLN A 1 254 ? 16.40791  20.96353  -26.21142 1.000 43.64061 ? 256 GLN A CB  1 
ATOM   1925 C CG  . GLN A 1 254 ? 16.75978  20.61732  -24.78689 1.000 46.67673 ? 256 GLN A CG  1 
ATOM   1926 C CD  . GLN A 1 254 ? 15.54831  20.31565  -23.94448 1.000 50.88953 ? 256 GLN A CD  1 
ATOM   1927 O OE1 . GLN A 1 254 ? 14.40676  20.47757  -24.38811 1.000 50.17001 ? 256 GLN A OE1 1 
ATOM   1928 N NE2 . GLN A 1 254 ? 15.78564  19.87433  -22.71213 1.000 51.66714 ? 256 GLN A NE2 1 
ATOM   1929 N N   . THR A 1 255 ? 18.70553  19.52015  -27.86911 1.000 40.66131 ? 257 THR A N   1 
ATOM   1930 C CA  . THR A 1 255 ? 19.71345  18.46455  -27.84578 1.000 42.45207 ? 257 THR A CA  1 
ATOM   1931 C C   . THR A 1 255 ? 20.89789  18.74220  -28.75418 1.000 40.06608 ? 257 THR A C   1 
ATOM   1932 O O   . THR A 1 255 ? 21.94255  18.10893  -28.58886 1.000 44.44315 ? 257 THR A O   1 
ATOM   1933 C CB  . THR A 1 255 ? 19.10618  17.12106  -28.26809 1.000 36.29283 ? 257 THR A CB  1 
ATOM   1934 O OG1 . THR A 1 255 ? 18.50248  17.26763  -29.56086 1.000 36.15317 ? 257 THR A OG1 1 
ATOM   1935 C CG2 . THR A 1 255 ? 18.06713  16.64866  -27.25272 1.000 37.99252 ? 257 THR A CG2 1 
ATOM   1936 N N   . GLY A 1 256 ? 20.75844  19.64972  -29.71443 1.000 38.89783 ? 258 GLY A N   1 
ATOM   1937 C CA  . GLY A 1 256 ? 21.79363  19.81615  -30.70726 1.000 42.29333 ? 258 GLY A CA  1 
ATOM   1938 C C   . GLY A 1 256 ? 21.81267  18.73155  -31.75581 1.000 44.32825 ? 258 GLY A C   1 
ATOM   1939 O O   . GLY A 1 256 ? 22.81846  18.57251  -32.44691 1.000 43.47643 ? 258 GLY A O   1 
ATOM   1940 N N   . ILE A 1 257 ? 20.72732  17.97076  -31.89303 1.000 39.01819 ? 259 ILE A N   1 
ATOM   1941 C CA  . ILE A 1 257 ? 20.62589  16.91251  -32.89039 1.000 34.57672 ? 259 ILE A CA  1 
ATOM   1942 C C   . ILE A 1 257 ? 19.53915  17.30218  -33.88008 1.000 38.37826 ? 259 ILE A C   1 
ATOM   1943 O O   . ILE A 1 257 ? 18.37542  17.47787  -33.49416 1.000 35.32755 ? 259 ILE A O   1 
ATOM   1944 C CB  . ILE A 1 257 ? 20.31982  15.55238  -32.25009 1.000 35.03406 ? 259 ILE A CB  1 
ATOM   1945 C CG1 . ILE A 1 257 ? 21.41825  15.17138  -31.25537 1.000 41.13087 ? 259 ILE A CG1 1 
ATOM   1946 C CG2 . ILE A 1 257 ? 20.14476  14.49326  -33.34390 1.000 34.37055 ? 259 ILE A CG2 1 
ATOM   1947 C CD1 . ILE A 1 257 ? 21.01504  14.10558  -30.27101 1.000 32.85051 ? 259 ILE A CD1 1 
ATOM   1948 N N   . ALA A 1 258 ? 19.91679  17.42654  -35.15427 1.000 37.83772 ? 260 ALA A N   1 
ATOM   1949 C CA  . ALA A 1 258 ? 18.95576  17.75389  -36.19976 1.000 35.34847 ? 260 ALA A CA  1 
ATOM   1950 C C   . ALA A 1 258 ? 17.92000  16.64289  -36.34469 1.000 34.16439 ? 260 ALA A C   1 
ATOM   1951 O O   . ALA A 1 258 ? 18.19777  15.46683  -36.08852 1.000 28.62081 ? 260 ALA A O   1 
ATOM   1952 C CB  . ALA A 1 258 ? 19.67301  17.97805  -37.53301 1.000 36.36763 ? 260 ALA A CB  1 
ATOM   1953 N N   . VAL A 1 259 ? 16.70941  17.02961  -36.77054 1.000 32.16564 ? 261 VAL A N   1 
ATOM   1954 C CA  . VAL A 1 259 ? 15.59655  16.08147  -36.84066 1.000 31.99054 ? 261 VAL A CA  1 
ATOM   1955 C C   . VAL A 1 259 ? 15.92590  14.92897  -37.78159 1.000 30.32896 ? 261 VAL A C   1 
ATOM   1956 O O   . VAL A 1 259 ? 15.69841  13.75759  -37.45908 1.000 26.87006 ? 261 VAL A O   1 
ATOM   1957 C CB  . VAL A 1 259 ? 14.30001  16.79523  -37.27691 1.000 32.02778 ? 261 VAL A CB  1 
ATOM   1958 C CG1 . VAL A 1 259 ? 13.18928  15.78361  -37.46129 1.000 33.64355 ? 261 VAL A CG1 1 
ATOM   1959 C CG2 . VAL A 1 259 ? 13.90504  17.85463  -36.26294 1.000 34.23719 ? 261 VAL A CG2 1 
ATOM   1960 N N   . LEU A 1 260 ? 16.46523  15.24322  -38.96454 1.000 29.63137 ? 262 LEU A N   1 
ATOM   1961 C CA  . LEU A 1 260 ? 16.79925  14.18936  -39.91765 1.000 31.92396 ? 262 LEU A CA  1 
ATOM   1962 C C   . LEU A 1 260 ? 17.95491  13.31719  -39.42329 1.000 28.90902 ? 262 LEU A C   1 
ATOM   1963 O O   . LEU A 1 260 ? 18.06285  12.15526  -39.82991 1.000 29.43446 ? 262 LEU A O   1 
ATOM   1964 C CB  . LEU A 1 260 ? 17.11516  14.80518  -41.28141 1.000 33.59770 ? 262 LEU A CB  1 
ATOM   1965 C CG  . LEU A 1 260 ? 15.91089  15.48221  -41.94826 1.000 34.44553 ? 262 LEU A CG  1 
ATOM   1966 C CD1 . LEU A 1 260 ? 16.36336  16.28404  -43.16116 1.000 37.99758 ? 262 LEU A CD1 1 
ATOM   1967 C CD2 . LEU A 1 260 ? 14.84451  14.46836  -42.34639 1.000 31.69176 ? 262 LEU A CD2 1 
ATOM   1968 N N   . ASP A 1 261 ? 18.81698  13.85179  -38.55549 1.000 28.46293 ? 263 ASP A N   1 
ATOM   1969 C CA  . ASP A 1 261 ? 19.81376  13.02387  -37.87007 1.000 31.61369 ? 263 ASP A CA  1 
ATOM   1970 C C   . ASP A 1 261 ? 19.15195  12.02213  -36.91056 1.000 30.57702 ? 263 ASP A C   1 
ATOM   1971 O O   . ASP A 1 261 ? 19.53200  10.84270  -36.86550 1.000 28.48517 ? 263 ASP A O   1 
ATOM   1972 C CB  . ASP A 1 261 ? 20.80370  13.91236  -37.11255 1.000 33.77612 ? 263 ASP A CB  1 
ATOM   1973 C CG  . ASP A 1 261 ? 21.80590  14.62601  -38.03086 1.000 35.48553 ? 263 ASP A CG  1 
ATOM   1974 O OD1 . ASP A 1 261 ? 21.69452  14.54082  -39.26525 1.000 34.77112 ? 263 ASP A OD1 1 
ATOM   1975 O OD2 . ASP A 1 261 ? 22.72102  15.28414  -37.49353 1.000 40.18065 ? 263 ASP A OD2 1 
ATOM   1976 N N   . MET A 1 262 ? 18.17878  12.47336  -36.10915 1.000 28.67843 ? 264 MET A N   1 
ATOM   1977 C CA  . MET A 1 262 ? 17.42938  11.52563  -35.28097 1.000 26.24372 ? 264 MET A CA  1 
ATOM   1978 C C   . MET A 1 262 ? 16.69594  10.50334  -36.14097 1.000 23.39143 ? 264 MET A C   1 
ATOM   1979 O O   . MET A 1 262 ? 16.63260  9.31834   -35.79440 1.000 25.80464 ? 264 MET A O   1 
ATOM   1980 C CB  . MET A 1 262 ? 16.43334  12.25535  -34.37246 1.000 27.99976 ? 264 MET A CB  1 
ATOM   1981 C CG  . MET A 1 262 ? 15.90421  11.36405  -33.24907 1.000 27.04455 ? 264 MET A CG  1 
ATOM   1982 S SD  . MET A 1 262 ? 17.21830  10.72006  -32.16037 1.000 30.67211 ? 264 MET A SD  1 
ATOM   1983 C CE  . MET A 1 262 ? 17.35672  12.06523  -30.98547 1.000 28.97640 ? 264 MET A CE  1 
ATOM   1984 N N   . CYS A 1 263 ? 16.14605  10.94574  -37.27262 1.000 26.12145 ? 265 CYS A N   1 
ATOM   1985 C CA  . CYS A 1 263 ? 15.50621  10.03115  -38.20901 1.000 24.28359 ? 265 CYS A CA  1 
ATOM   1986 C C   . CYS A 1 263 ? 16.47122  8.95278   -38.68155 1.000 27.15730 ? 265 CYS A C   1 
ATOM   1987 O O   . CYS A 1 263 ? 16.07638  7.79719   -38.87568 1.000 23.15286 ? 265 CYS A O   1 
ATOM   1988 C CB  . CYS A 1 263 ? 14.96621  10.80632  -39.41011 1.000 29.27387 ? 265 CYS A CB  1 
ATOM   1989 S SG  . CYS A 1 263 ? 13.44874  11.76904  -39.06273 1.000 29.74586 ? 265 CYS A SG  1 
ATOM   1990 N N   . ALA A 1 264 ? 17.73446  9.32174   -38.91116 1.000 25.87324 ? 266 ALA A N   1 
ATOM   1991 C CA  . ALA A 1 264 ? 18.73118  8.32072   -39.29991 1.000 28.49060 ? 266 ALA A CA  1 
ATOM   1992 C C   . ALA A 1 264 ? 18.92067  7.29003   -38.19761 1.000 23.95714 ? 266 ALA A C   1 
ATOM   1993 O O   . ALA A 1 264 ? 19.06796  6.09035   -38.46613 1.000 24.41799 ? 266 ALA A O   1 
ATOM   1994 C CB  . ALA A 1 264 ? 20.06418  9.00326   -39.61881 1.000 24.95849 ? 266 ALA A CB  1 
ATOM   1995 N N   . SER A 1 265 ? 18.92086  7.75049   -36.94891 1.000 21.75861 ? 267 SER A N   1 
ATOM   1996 C CA  . SER A 1 265 ? 19.01933  6.84545   -35.81193 1.000 25.32311 ? 267 SER A CA  1 
ATOM   1997 C C   . SER A 1 265 ? 17.82446  5.89820   -35.76283 1.000 25.20423 ? 267 SER A C   1 
ATOM   1998 O O   . SER A 1 265 ? 17.97708  4.68800   -35.54703 1.000 24.67182 ? 267 SER A O   1 
ATOM   1999 C CB  . SER A 1 265 ? 19.13125  7.66827   -34.52888 1.000 29.65653 ? 267 SER A CB  1 
ATOM   2000 O OG  . SER A 1 265 ? 18.87296  6.88244   -33.37485 1.000 36.71030 ? 267 SER A OG  1 
ATOM   2001 N N   . LEU A 1 266 ? 16.61975  6.43084   -35.97464 1.000 25.68784 ? 268 LEU A N   1 
ATOM   2002 C CA  . LEU A 1 266 ? 15.43739  5.57020   -35.99050 1.000 22.32684 ? 268 LEU A CA  1 
ATOM   2003 C C   . LEU A 1 266 ? 15.56752  4.47963   -37.04982 1.000 22.69844 ? 268 LEU A C   1 
ATOM   2004 O O   . LEU A 1 266 ? 15.30368  3.30071   -36.77849 1.000 25.62631 ? 268 LEU A O   1 
ATOM   2005 C CB  . LEU A 1 266 ? 14.18071  6.41640   -36.22906 1.000 22.12207 ? 268 LEU A CB  1 
ATOM   2006 C CG  . LEU A 1 266 ? 12.86597  5.62901   -36.25720 1.000 27.32783 ? 268 LEU A CG  1 
ATOM   2007 C CD1 . LEU A 1 266 ? 12.79119  4.61506   -35.12255 1.000 25.07330 ? 268 LEU A CD1 1 
ATOM   2008 C CD2 . LEU A 1 266 ? 11.65378  6.58700   -36.19666 1.000 24.33976 ? 268 LEU A CD2 1 
ATOM   2009 N N   . LYS A 1 267 ? 15.96619  4.86020   -38.27106 1.000 24.40381 ? 269 LYS A N   1 
ATOM   2010 C CA  . LYS A 1 267 ? 16.15395  3.88520   -39.34584 1.000 25.83650 ? 269 LYS A CA  1 
ATOM   2011 C C   . LYS A 1 267 ? 17.05924  2.74610   -38.90150 1.000 22.25601 ? 269 LYS A C   1 
ATOM   2012 O O   . LYS A 1 267 ? 16.76148  1.56871   -39.14411 1.000 23.93358 ? 269 LYS A O   1 
ATOM   2013 C CB  . LYS A 1 267 ? 16.74210  4.57029   -40.58976 1.000 27.40919 ? 269 LYS A CB  1 
ATOM   2014 C CG  . LYS A 1 267 ? 15.73519  5.38959   -41.40019 1.000 34.32670 ? 269 LYS A CG  1 
ATOM   2015 C CD  . LYS A 1 267 ? 16.44929  6.39286   -42.32669 1.000 38.47331 ? 269 LYS A CD  1 
ATOM   2016 C CE  . LYS A 1 267 ? 17.26821  5.69705   -43.39666 1.000 34.89441 ? 269 LYS A CE  1 
ATOM   2017 N NZ  . LYS A 1 267 ? 17.69955  6.67679   -44.45592 1.000 35.68921 ? 269 LYS A NZ  1 
ATOM   2018 N N   . GLU A 1 268 ? 18.15701  3.07684   -38.21591 1.000 24.74018 ? 270 GLU A N   1 
ATOM   2019 C CA  . GLU A 1 268 ? 19.08273  2.04632   -37.76372 1.000 24.44812 ? 270 GLU A CA  1 
ATOM   2020 C C   . GLU A 1 268 ? 18.48255  1.20348   -36.63750 1.000 23.52976 ? 270 GLU A C   1 
ATOM   2021 O O   . GLU A 1 268 ? 18.70906  -0.01128  -36.58079 1.000 24.70205 ? 270 GLU A O   1 
ATOM   2022 C CB  . GLU A 1 268 ? 20.39853  2.69229   -37.32459 1.000 26.63884 ? 270 GLU A CB  1 
ATOM   2023 C CG  . GLU A 1 268 ? 21.44782  1.72621   -36.82916 1.000 25.46552 ? 270 GLU A CG  1 
ATOM   2024 C CD  . GLU A 1 268 ? 22.80636  2.40162   -36.74517 1.000 31.37434 ? 270 GLU A CD  1 
ATOM   2025 O OE1 . GLU A 1 268 ? 23.57917  2.27598   -37.70286 1.000 32.70111 ? 270 GLU A OE1 1 
ATOM   2026 O OE2 . GLU A 1 268 ? 23.08467  3.09980   -35.74851 1.000 34.32515 ? 270 GLU A OE2 1 
ATOM   2027 N N   . LEU A 1 269 ? 17.70839  1.82000   -35.73930 1.000 24.91981 ? 271 LEU A N   1 
ATOM   2028 C CA  . LEU A 1 269 ? 17.04166  1.04513   -34.69483 1.000 25.19983 ? 271 LEU A CA  1 
ATOM   2029 C C   . LEU A 1 269 ? 16.07841  0.02177   -35.28672 1.000 27.11800 ? 271 LEU A C   1 
ATOM   2030 O O   . LEU A 1 269 ? 15.99144  -1.11256  -34.79481 1.000 25.25060 ? 271 LEU A O   1 
ATOM   2031 C CB  . LEU A 1 269 ? 16.31010  1.97384   -33.72076 1.000 25.54496 ? 271 LEU A CB  1 
ATOM   2032 C CG  . LEU A 1 269 ? 17.25477  2.60524   -32.68580 1.000 26.32825 ? 271 LEU A CG  1 
ATOM   2033 C CD1 . LEU A 1 269 ? 16.61242  3.76976   -31.94561 1.000 27.69503 ? 271 LEU A CD1 1 
ATOM   2034 C CD2 . LEU A 1 269 ? 17.75063  1.56224   -31.70081 1.000 30.24510 ? 271 LEU A CD2 1 
ATOM   2035 N N   . LEU A 1 270 ? 15.34916  0.40246   -36.34363 1.000 24.29666 ? 272 LEU A N   1 
ATOM   2036 C CA  . LEU A 1 270 ? 14.42853  -0.53113  -36.98987 1.000 26.85034 ? 272 LEU A CA  1 
ATOM   2037 C C   . LEU A 1 270 ? 15.18899  -1.66179  -37.66312 1.000 28.83360 ? 272 LEU A C   1 
ATOM   2038 O O   . LEU A 1 270 ? 14.73955  -2.81433  -37.66728 1.000 25.51605 ? 272 LEU A O   1 
ATOM   2039 C CB  . LEU A 1 270 ? 13.55478  0.20717   -38.00784 1.000 23.97664 ? 272 LEU A CB  1 
ATOM   2040 C CG  . LEU A 1 270 ? 12.58094  1.17577   -37.33671 1.000 25.60420 ? 272 LEU A CG  1 
ATOM   2041 C CD1 . LEU A 1 270 ? 11.90784  2.07373   -38.35421 1.000 26.23359 ? 272 LEU A CD1 1 
ATOM   2042 C CD2 . LEU A 1 270 ? 11.55165  0.37470   -36.54741 1.000 28.32746 ? 272 LEU A CD2 1 
ATOM   2043 N N   . GLN A 1 271 ? 16.35757  -1.34725  -38.21654 1.000 26.92097 ? 273 GLN A N   1 
ATOM   2044 C CA  . GLN A 1 271 ? 17.16934  -2.36143  -38.87253 1.000 26.52362 ? 273 GLN A CA  1 
ATOM   2045 C C   . GLN A 1 271 ? 17.84391  -3.28870  -37.86110 1.000 25.75657 ? 273 GLN A C   1 
ATOM   2046 O O   . GLN A 1 271 ? 17.94095  -4.49598  -38.09616 1.000 26.90450 ? 273 GLN A O   1 
ATOM   2047 C CB  . GLN A 1 271 ? 18.18704  -1.65739  -39.76365 1.000 25.16386 ? 273 GLN A CB  1 
ATOM   2048 C CG  . GLN A 1 271 ? 19.38515  -2.44642  -40.17951 1.000 24.10325 ? 273 GLN A CG  1 
ATOM   2049 C CD  . GLN A 1 271 ? 20.47119  -1.50471  -40.67591 1.000 24.83605 ? 273 GLN A CD  1 
ATOM   2050 O OE1 . GLN A 1 271 ? 20.36548  -0.94954  -41.77054 1.000 23.40899 ? 273 GLN A OE1 1 
ATOM   2051 N NE2 . GLN A 1 271 ? 21.48365  -1.27877  -39.84741 1.000 23.46641 ? 273 GLN A NE2 1 
ATOM   2052 N N   . ASN A 1 272 ? 18.30262  -2.75518  -36.72738 1.000 25.91182 ? 274 ASN A N   1 
ATOM   2053 C CA  . ASN A 1 272 ? 19.13246  -3.52861  -35.80859 1.000 25.63624 ? 274 ASN A CA  1 
ATOM   2054 C C   . ASN A 1 272 ? 18.37917  -4.06694  -34.59510 1.000 33.12863 ? 274 ASN A C   1 
ATOM   2055 O O   . ASN A 1 272 ? 18.87785  -4.99298  -33.94354 1.000 32.86864 ? 274 ASN A O   1 
ATOM   2056 C CB  . ASN A 1 272 ? 20.29404  -2.67951  -35.28258 1.000 23.30631 ? 274 ASN A CB  1 
ATOM   2057 C CG  . ASN A 1 272 ? 21.30905  -2.34358  -36.36091 1.000 25.61313 ? 274 ASN A CG  1 
ATOM   2058 O OD1 . ASN A 1 272 ? 21.25316  -2.88586  -37.46167 1.000 25.94082 ? 274 ASN A OD1 1 
ATOM   2059 N ND2 . ASN A 1 272 ? 22.24596  -1.46198  -36.04142 1.000 24.12977 ? 274 ASN A ND2 1 
ATOM   2060 N N   . GLY A 1 273 ? 17.22593  -3.49486  -34.25560 1.000 32.70869 ? 275 GLY A N   1 
ATOM   2061 C CA  . GLY A 1 273 ? 16.66057  -3.79212  -32.94209 1.000 32.94628 ? 275 GLY A CA  1 
ATOM   2062 C C   . GLY A 1 273 ? 17.49188  -3.13709  -31.84432 1.000 33.41626 ? 275 GLY A C   1 
ATOM   2063 O O   . GLY A 1 273 ? 18.34363  -2.27794  -32.09209 1.000 32.74783 ? 275 GLY A O   1 
ATOM   2064 N N   . MET A 1 274 ? 17.25061  -3.57033  -30.60481 1.000 35.40443 ? 276 MET A N   1 
ATOM   2065 C CA  . MET A 1 274 ? 17.91660  -2.96051  -29.46007 1.000 40.28741 ? 276 MET A CA  1 
ATOM   2066 C C   . MET A 1 274 ? 19.15582  -3.71392  -28.99044 1.000 39.19941 ? 276 MET A C   1 
ATOM   2067 O O   . MET A 1 274 ? 19.94177  -3.14766  -28.21925 1.000 39.25590 ? 276 MET A O   1 
ATOM   2068 C CB  . MET A 1 274 ? 16.93090  -2.81772  -28.29499 1.000 41.69273 ? 276 MET A CB  1 
ATOM   2069 C CG  . MET A 1 274 ? 15.84966  -1.77303  -28.55519 1.000 42.67123 ? 276 MET A CG  1 
ATOM   2070 S SD  . MET A 1 274 ? 15.46549  -0.77681  -27.10113 1.000 50.18516 ? 276 MET A SD  1 
ATOM   2071 C CE  . MET A 1 274 ? 13.94694  -0.03388  -27.67615 1.000 36.97380 ? 276 MET A CE  1 
ATOM   2072 N N   . ASN A 1 275 ? 19.35717  -4.95263  -29.44678 1.000 39.84951 ? 277 ASN A N   1 
ATOM   2073 C CA  . ASN A 1 275 ? 20.49810  -5.78163  -29.04833 1.000 43.62706 ? 277 ASN A CA  1 
ATOM   2074 C C   . ASN A 1 275 ? 20.60158  -5.87125  -27.52402 1.000 44.54444 ? 277 ASN A C   1 
ATOM   2075 O O   . ASN A 1 275 ? 21.64682  -5.60588  -26.92511 1.000 42.94851 ? 277 ASN A O   1 
ATOM   2076 C CB  . ASN A 1 275 ? 21.80447  -5.26569  -29.67228 1.000 42.15938 ? 277 ASN A CB  1 
ATOM   2077 C CG  . ASN A 1 275 ? 21.91348  -5.59266  -31.16782 1.000 50.27063 ? 277 ASN A CG  1 
ATOM   2078 O OD1 . ASN A 1 275 ? 21.84400  -4.69873  -32.02498 1.000 47.52594 ? 277 ASN A OD1 1 
ATOM   2079 N ND2 . ASN A 1 275 ? 22.07973  -6.87536  -31.48427 1.000 50.30894 ? 277 ASN A ND2 1 
ATOM   2080 N N   . GLY A 1 276 ? 19.48406  -6.23729  -26.89511 1.000 46.14973 ? 278 GLY A N   1 
ATOM   2081 C CA  . GLY A 1 276 ? 19.41927  -6.43128  -25.46069 1.000 46.92238 ? 278 GLY A CA  1 
ATOM   2082 C C   . GLY A 1 276 ? 19.44182  -5.17112  -24.62508 1.000 49.33261 ? 278 GLY A C   1 
ATOM   2083 O O   . GLY A 1 276 ? 19.36294  -5.26595  -23.39259 1.000 49.08482 ? 278 GLY A O   1 
ATOM   2084 N N   . ARG A 1 277 ? 19.54578  -3.99739  -25.24379 1.000 43.99114 ? 279 ARG A N   1 
ATOM   2085 C CA  . ARG A 1 277 ? 19.68605  -2.75628  -24.50602 1.000 40.07639 ? 279 ARG A CA  1 
ATOM   2086 C C   . ARG A 1 277 ? 18.31616  -2.13247  -24.25244 1.000 42.09301 ? 279 ARG A C   1 
ATOM   2087 O O   . ARG A 1 277 ? 17.27551  -2.63317  -24.68865 1.000 42.06721 ? 279 ARG A O   1 
ATOM   2088 C CB  . ARG A 1 277 ? 20.59531  -1.78766  -25.25524 1.000 37.01900 ? 279 ARG A CB  1 
ATOM   2089 C CG  . ARG A 1 277 ? 22.06860  -2.08998  -25.09010 1.000 40.30855 ? 279 ARG A CG  1 
ATOM   2090 C CD  . ARG A 1 277 ? 22.90751  -1.25654  -26.01757 1.000 40.34887 ? 279 ARG A CD  1 
ATOM   2091 N NE  . ARG A 1 277 ? 22.65053  -1.59873  -27.41346 1.000 42.45594 ? 279 ARG A NE  1 
ATOM   2092 C CZ  . ARG A 1 277 ? 23.50971  -1.37901  -28.40322 1.000 39.69346 ? 279 ARG A CZ  1 
ATOM   2093 N NH1 . ARG A 1 277 ? 24.68381  -0.81874  -28.14388 1.000 44.93724 ? 279 ARG A NH1 1 
ATOM   2094 N NH2 . ARG A 1 277 ? 23.19626  -1.71816  -29.65064 1.000 40.27778 ? 279 ARG A NH2 1 
ATOM   2095 N N   . THR A 1 278 ? 18.32578  -1.00822  -23.54719 1.000 37.11367 ? 280 THR A N   1 
ATOM   2096 C CA  . THR A 1 278 ? 17.11542  -0.31448  -23.15620 1.000 38.72886 ? 280 THR A CA  1 
ATOM   2097 C C   . THR A 1 278 ? 17.21669  1.15292   -23.55325 1.000 39.04635 ? 280 THR A C   1 
ATOM   2098 O O   . THR A 1 278 ? 18.30809  1.71950   -23.62309 1.000 32.39365 ? 280 THR A O   1 
ATOM   2099 C CB  . THR A 1 278 ? 16.88797  -0.44604  -21.64222 1.000 39.31400 ? 280 THR A CB  1 
ATOM   2100 O OG1 . THR A 1 278 ? 15.54194  -0.10112  -21.35076 1.000 50.53652 ? 280 THR A OG1 1 
ATOM   2101 C CG2 . THR A 1 278 ? 17.81048  0.48480   -20.86474 1.000 38.19149 ? 280 THR A CG2 1 
ATOM   2102 N N   . ILE A 1 279 ? 16.06684  1.76377   -23.83034 1.000 34.87087 ? 281 ILE A N   1 
ATOM   2103 C CA  . ILE A 1 279 ? 15.97046  3.20038   -24.05162 1.000 31.03743 ? 281 ILE A CA  1 
ATOM   2104 C C   . ILE A 1 279 ? 14.93833  3.73696   -23.07155 1.000 37.25699 ? 281 ILE A C   1 
ATOM   2105 O O   . ILE A 1 279 ? 13.76289  3.35437   -23.13769 1.000 42.64875 ? 281 ILE A O   1 
ATOM   2106 C CB  . ILE A 1 279 ? 15.56616  3.56030   -25.49134 1.000 31.37559 ? 281 ILE A CB  1 
ATOM   2107 C CG1 . ILE A 1 279 ? 16.62846  3.11589   -26.50501 1.000 26.51010 ? 281 ILE A CG1 1 
ATOM   2108 C CG2 . ILE A 1 279 ? 15.33169  5.05296   -25.59565 1.000 27.41559 ? 281 ILE A CG2 1 
ATOM   2109 C CD1 . ILE A 1 279 ? 16.20692  3.36836   -27.95779 1.000 26.99171 ? 281 ILE A CD1 1 
ATOM   2110 N N   . LEU A 1 280 ? 15.37212  4.62515   -22.17388 1.000 36.34674 ? 282 LEU A N   1 
ATOM   2111 C CA  . LEU A 1 280 ? 14.50732  5.13306   -21.10532 1.000 39.76456 ? 282 LEU A CA  1 
ATOM   2112 C C   . LEU A 1 280 ? 13.80606  3.98390   -20.39151 1.000 41.40946 ? 282 LEU A C   1 
ATOM   2113 O O   . LEU A 1 280 ? 12.60704  4.03117   -20.11809 1.000 46.00471 ? 282 LEU A O   1 
ATOM   2114 C CB  . LEU A 1 280 ? 13.48157  6.13026   -21.64524 1.000 38.59386 ? 282 LEU A CB  1 
ATOM   2115 C CG  . LEU A 1 280 ? 13.97839  7.51890   -22.03480 1.000 36.61471 ? 282 LEU A CG  1 
ATOM   2116 C CD1 . LEU A 1 280 ? 12.85182  8.30736   -22.69310 1.000 38.10899 ? 282 LEU A CD1 1 
ATOM   2117 C CD2 . LEU A 1 280 ? 14.51251  8.25094   -20.82465 1.000 39.50030 ? 282 LEU A CD2 1 
ATOM   2118 N N   . GLY A 1 281 ? 14.54621  2.91008   -20.13864 1.000 41.85610 ? 283 GLY A N   1 
ATOM   2119 C CA  . GLY A 1 281 ? 14.01902  1.81294   -19.36498 1.000 41.84109 ? 283 GLY A CA  1 
ATOM   2120 C C   . GLY A 1 281 ? 13.22985  0.76500   -20.12059 1.000 40.12377 ? 283 GLY A C   1 
ATOM   2121 O O   . GLY A 1 281 ? 12.98330  -0.30653  -19.55824 1.000 46.87867 ? 283 GLY A O   1 
ATOM   2122 N N   . SER A 1 282 ? 12.85237  0.99618   -21.37863 1.000 39.25377 ? 284 SER A N   1 
ATOM   2123 C CA  . SER A 1 282 ? 12.03365  0.01713   -22.08350 1.000 38.97888 ? 284 SER A CA  1 
ATOM   2124 C C   . SER A 1 282 ? 12.79603  -0.66129  -23.21719 1.000 38.90409 ? 284 SER A C   1 
ATOM   2125 O O   . SER A 1 282 ? 13.67208  -0.06853  -23.85587 1.000 34.44630 ? 284 SER A O   1 
ATOM   2126 C CB  . SER A 1 282 ? 10.74475  0.63541   -22.63691 1.000 40.26437 ? 284 SER A CB  1 
ATOM   2127 O OG  . SER A 1 282 ? 10.98553  1.47950   -23.73129 1.000 45.42029 ? 284 SER A OG  1 
ATOM   2128 N N   . ALA A 1 283 ? 12.42926  -1.92466  -23.45259 1.000 38.01071 ? 285 ALA A N   1 
ATOM   2129 C CA  . ALA A 1 283 ? 12.92275  -2.76279  -24.53659 1.000 40.27975 ? 285 ALA A CA  1 
ATOM   2130 C C   . ALA A 1 283 ? 12.17823  -2.52927  -25.84169 1.000 37.60088 ? 285 ALA A C   1 
ATOM   2131 O O   . ALA A 1 283 ? 12.41158  -3.25907  -26.81252 1.000 38.61093 ? 285 ALA A O   1 
ATOM   2132 C CB  . ALA A 1 283 ? 12.81228  -4.23595  -24.13813 1.000 39.81188 ? 285 ALA A CB  1 
ATOM   2133 N N   . LEU A 1 284 ? 11.30552  -1.52177  -25.88021 1.000 33.07388 ? 286 LEU A N   1 
ATOM   2134 C CA  . LEU A 1 284 ? 10.41019  -1.26940  -26.99739 1.000 36.93847 ? 286 LEU A CA  1 
ATOM   2135 C C   . LEU A 1 284 ? 10.53263  0.17774   -27.44225 1.000 28.97741 ? 286 LEU A C   1 
ATOM   2136 O O   . LEU A 1 284 ? 10.75626  1.07189   -26.62821 1.000 35.05748 ? 286 LEU A O   1 
ATOM   2137 C CB  . LEU A 1 284 ? 8.94336   -1.55594  -26.60544 1.000 41.63280 ? 286 LEU A CB  1 
ATOM   2138 C CG  . LEU A 1 284 ? 8.66146   -3.02320  -26.32802 1.000 38.05449 ? 286 LEU A CG  1 
ATOM   2139 C CD1 . LEU A 1 284 ? 7.17991   -3.24679  -26.05622 1.000 42.34683 ? 286 LEU A CD1 1 
ATOM   2140 C CD2 . LEU A 1 284 ? 9.10932   -3.80035  -27.54092 1.000 47.00849 ? 286 LEU A CD2 1 
ATOM   2141 N N   . LEU A 1 285 ? 10.37047  0.40998   -28.73831 1.000 27.04963 ? 287 LEU A N   1 
ATOM   2142 C CA  . LEU A 1 285 ? 10.25263  1.77853   -29.22795 1.000 29.87808 ? 287 LEU A CA  1 
ATOM   2143 C C   . LEU A 1 285 ? 8.85753   2.27900   -28.86587 1.000 31.15503 ? 287 LEU A C   1 
ATOM   2144 O O   . LEU A 1 285 ? 7.85906   1.80657   -29.41126 1.000 32.91698 ? 287 LEU A O   1 
ATOM   2145 C CB  . LEU A 1 285 ? 10.50640  1.84268   -30.73159 1.000 28.78847 ? 287 LEU A CB  1 
ATOM   2146 C CG  . LEU A 1 285 ? 11.90817  1.39147   -31.16673 1.000 28.98345 ? 287 LEU A CG  1 
ATOM   2147 C CD1 . LEU A 1 285 ? 12.06828  1.42470   -32.68800 1.000 26.33222 ? 287 LEU A CD1 1 
ATOM   2148 C CD2 . LEU A 1 285 ? 12.97424  2.25507   -30.48000 1.000 31.53908 ? 287 LEU A CD2 1 
ATOM   2149 N N   . GLU A 1 286 ? 8.79196   3.22031   -27.93833 1.000 30.30034 ? 288 GLU A N   1 
ATOM   2150 C CA  . GLU A 1 286 ? 7.52457   3.70520   -27.40138 1.000 28.98743 ? 288 GLU A CA  1 
ATOM   2151 C C   . GLU A 1 286 ? 6.93412   4.78861   -28.30207 1.000 28.12521 ? 288 GLU A C   1 
ATOM   2152 O O   . GLU A 1 286 ? 7.63017   5.73563   -28.66861 1.000 25.01629 ? 288 GLU A O   1 
ATOM   2153 C CB  . GLU A 1 286 ? 7.76922   4.25723   -25.99798 1.000 30.61582 ? 288 GLU A CB  1 
ATOM   2154 C CG  . GLU A 1 286 ? 6.57091   4.90221   -25.37458 1.000 37.27280 ? 288 GLU A CG  1 
ATOM   2155 C CD  . GLU A 1 286 ? 5.51025   3.89253   -25.01466 1.000 38.71716 ? 288 GLU A CD  1 
ATOM   2156 O OE1 . GLU A 1 286 ? 5.87335   2.84182   -24.43071 1.000 41.50129 ? 288 GLU A OE1 1 
ATOM   2157 O OE2 . GLU A 1 286 ? 4.32651   4.14990   -25.33351 1.000 38.69613 ? 288 GLU A OE2 1 
ATOM   2158 N N   . ASP A 1 287 ? 5.63951   4.67829   -28.64944 1.000 26.92945 ? 289 ASP A N   1 
ATOM   2159 C CA  . ASP A 1 287 ? 5.04055   5.70194   -29.50279 1.000 23.43275 ? 289 ASP A CA  1 
ATOM   2160 C C   . ASP A 1 287 ? 3.81405   6.37033   -28.87862 1.000 29.26496 ? 289 ASP A C   1 
ATOM   2161 O O   . ASP A 1 287 ? 3.01390   6.97147   -29.60380 1.000 25.71696 ? 289 ASP A O   1 
ATOM   2162 C CB  . ASP A 1 287 ? 4.71235   5.14223   -30.89917 1.000 25.19045 ? 289 ASP A CB  1 
ATOM   2163 C CG  . ASP A 1 287 ? 3.43031   4.26767   -30.94420 1.000 30.58469 ? 289 ASP A CG  1 
ATOM   2164 O OD1 . ASP A 1 287 ? 2.96342   3.77693   -29.89062 1.000 28.50478 ? 289 ASP A OD1 1 
ATOM   2165 O OD2 . ASP A 1 287 ? 2.91808   4.04927   -32.07476 1.000 27.23173 ? 289 ASP A OD2 1 
ATOM   2166 N N   . GLU A 1 288 ? 3.68461   6.35559   -27.55064 1.000 25.33690 ? 290 GLU A N   1 
ATOM   2167 C CA  . GLU A 1 288 ? 2.53156   6.97474   -26.90592 1.000 31.42409 ? 290 GLU A CA  1 
ATOM   2168 C C   . GLU A 1 288 ? 2.93145   8.12812   -25.98908 1.000 30.94008 ? 290 GLU A C   1 
ATOM   2169 O O   . GLU A 1 288 ? 2.24027   8.43882   -25.01454 1.000 28.37153 ? 290 GLU A O   1 
ATOM   2170 C CB  . GLU A 1 288 ? 1.72694   5.91581   -26.16514 1.000 29.39815 ? 290 GLU A CB  1 
ATOM   2171 C CG  . GLU A 1 288 ? 1.08603   4.90969   -27.11954 1.000 28.08322 ? 290 GLU A CG  1 
ATOM   2172 C CD  . GLU A 1 288 ? -0.08247  4.19021   -26.45708 1.000 38.10405 ? 290 GLU A CD  1 
ATOM   2173 O OE1 . GLU A 1 288 ? -0.00581  3.96093   -25.23438 1.000 38.50375 ? 290 GLU A OE1 1 
ATOM   2174 O OE2 . GLU A 1 288 ? -1.05860  3.85317   -27.15751 1.000 38.44394 ? 290 GLU A OE2 1 
ATOM   2175 N N   . PHE A 1 289 ? 4.04811   8.77572   -26.30121 1.000 26.84095 ? 291 PHE A N   1 
ATOM   2176 C CA  . PHE A 1 289 ? 4.40788   10.07673  -25.74814 1.000 26.66244 ? 291 PHE A CA  1 
ATOM   2177 C C   . PHE A 1 289 ? 4.46603   11.07106  -26.89736 1.000 27.87137 ? 291 PHE A C   1 
ATOM   2178 O O   . PHE A 1 289 ? 5.28307   10.91029  -27.80819 1.000 25.94505 ? 291 PHE A O   1 
ATOM   2179 C CB  . PHE A 1 289 ? 5.77426   10.03721  -25.06305 1.000 30.62271 ? 291 PHE A CB  1 
ATOM   2180 C CG  . PHE A 1 289 ? 5.82076   9.20752   -23.82627 1.000 33.43618 ? 291 PHE A CG  1 
ATOM   2181 C CD1 . PHE A 1 289 ? 5.39067   9.72124   -22.61713 1.000 33.30888 ? 291 PHE A CD1 1 
ATOM   2182 C CD2 . PHE A 1 289 ? 6.34593   7.92126   -23.86134 1.000 38.44351 ? 291 PHE A CD2 1 
ATOM   2183 C CE1 . PHE A 1 289 ? 5.45109   8.95313   -21.46242 1.000 43.48368 ? 291 PHE A CE1 1 
ATOM   2184 C CE2 . PHE A 1 289 ? 6.41206   7.14304   -22.70601 1.000 39.97296 ? 291 PHE A CE2 1 
ATOM   2185 C CZ  . PHE A 1 289 ? 5.96307   7.65971   -21.50726 1.000 40.36044 ? 291 PHE A CZ  1 
ATOM   2186 N N   . THR A 1 290 ? 3.65120   12.11585  -26.83749 1.000 26.99046 ? 292 THR A N   1 
ATOM   2187 C CA  . THR A 1 290 ? 3.66880   13.11906  -27.89063 1.000 28.09380 ? 292 THR A CA  1 
ATOM   2188 C C   . THR A 1 290 ? 4.81566   14.11176  -27.69037 1.000 26.80426 ? 292 THR A C   1 
ATOM   2189 O O   . THR A 1 290 ? 5.37639   14.21499  -26.59432 1.000 27.67397 ? 292 THR A O   1 
ATOM   2190 C CB  . THR A 1 290 ? 2.35267   13.87194  -27.91024 1.000 30.79736 ? 292 THR A CB  1 
ATOM   2191 O OG1 . THR A 1 290 ? 2.27751   14.67713  -26.73305 1.000 28.48569 ? 292 THR A OG1 1 
ATOM   2192 C CG2 . THR A 1 290 ? 1.18390   12.90235  -27.95524 1.000 29.39228 ? 292 THR A CG2 1 
ATOM   2193 N N   . PRO A 1 291 ? 5.18048   14.86107  -28.74049 1.000 28.20218 ? 293 PRO A N   1 
ATOM   2194 C CA  . PRO A 1 291 ? 6.17626   15.93624  -28.55390 1.000 28.05962 ? 293 PRO A CA  1 
ATOM   2195 C C   . PRO A 1 291 ? 5.77975   16.90093  -27.45275 1.000 30.73770 ? 293 PRO A C   1 
ATOM   2196 O O   . PRO A 1 291 ? 6.62863   17.31731  -26.65383 1.000 32.08014 ? 293 PRO A O   1 
ATOM   2197 C CB  . PRO A 1 291 ? 6.20491   16.61919  -29.92640 1.000 27.08596 ? 293 PRO A CB  1 
ATOM   2198 C CG  . PRO A 1 291 ? 5.80948   15.55219  -30.88311 1.000 28.90354 ? 293 PRO A CG  1 
ATOM   2199 C CD  . PRO A 1 291 ? 4.77344   14.73531  -30.15315 1.000 28.23142 ? 293 PRO A CD  1 
ATOM   2200 N N   . PHE A 1 292 ? 4.48582   17.23474  -27.37336 1.000 30.02970 ? 294 PHE A N   1 
ATOM   2201 C CA  . PHE A 1 292 ? 3.99784   18.08114  -26.29211 1.000 29.34207 ? 294 PHE A CA  1 
ATOM   2202 C C   . PHE A 1 292 ? 4.28519   17.44454  -24.94146 1.000 29.38141 ? 294 PHE A C   1 
ATOM   2203 O O   . PHE A 1 292 ? 4.77040   18.11463  -24.02483 1.000 35.18856 ? 294 PHE A O   1 
ATOM   2204 C CB  . PHE A 1 292 ? 2.49551   18.34871  -26.45555 1.000 31.81697 ? 294 PHE A CB  1 
ATOM   2205 C CG  . PHE A 1 292 ? 1.92555   19.29333  -25.41401 1.000 34.11531 ? 294 PHE A CG  1 
ATOM   2206 C CD1 . PHE A 1 292 ? 1.58771   18.83259  -24.14503 1.000 36.84403 ? 294 PHE A CD1 1 
ATOM   2207 C CD2 . PHE A 1 292 ? 1.73021   20.63821  -25.70637 1.000 33.57795 ? 294 PHE A CD2 1 
ATOM   2208 C CE1 . PHE A 1 292 ? 1.06995   19.69463  -23.17935 1.000 34.32150 ? 294 PHE A CE1 1 
ATOM   2209 C CE2 . PHE A 1 292 ? 1.21715   21.50543  -24.75214 1.000 39.75983 ? 294 PHE A CE2 1 
ATOM   2210 C CZ  . PHE A 1 292 ? 0.88158   21.02872  -23.48383 1.000 37.50142 ? 294 PHE A CZ  1 
ATOM   2211 N N   . ASP A 1 293 ? 3.97223   16.14964  -24.79867 1.000 28.79928 ? 295 ASP A N   1 
ATOM   2212 C CA  . ASP A 1 293 ? 4.23925   15.43733  -23.55062 1.000 29.56013 ? 295 ASP A CA  1 
ATOM   2213 C C   . ASP A 1 293 ? 5.71635   15.54125  -23.18694 1.000 35.51356 ? 295 ASP A C   1 
ATOM   2214 O O   . ASP A 1 293 ? 6.07106   15.85723  -22.04717 1.000 38.08252 ? 295 ASP A O   1 
ATOM   2215 C CB  . ASP A 1 293 ? 3.81205   13.95762  -23.67611 1.000 28.11807 ? 295 ASP A CB  1 
ATOM   2216 C CG  . ASP A 1 293 ? 2.27687   13.77143  -23.84900 1.000 39.28593 ? 295 ASP A CG  1 
ATOM   2217 O OD1 . ASP A 1 293 ? 1.51233   14.67569  -23.42970 1.000 38.44889 ? 295 ASP A OD1 1 
ATOM   2218 O OD2 . ASP A 1 293 ? 1.83644   12.71607  -24.39752 1.000 30.82405 ? 295 ASP A OD2 1 
ATOM   2219 N N   . VAL A 1 294 ? 6.59223   15.32343  -24.16696 1.000 31.32910 ? 296 VAL A N   1 
ATOM   2220 C CA  . VAL A 1 294 ? 8.03052   15.27259  -23.89825 1.000 36.92342 ? 296 VAL A CA  1 
ATOM   2221 C C   . VAL A 1 294 ? 8.56006   16.65309  -23.52720 1.000 36.91735 ? 296 VAL A C   1 
ATOM   2222 O O   . VAL A 1 294 ? 9.33823   16.80187  -22.57853 1.000 40.72418 ? 296 VAL A O   1 
ATOM   2223 C CB  . VAL A 1 294 ? 8.78177   14.68976  -25.10958 1.000 33.10304 ? 296 VAL A CB  1 
ATOM   2224 C CG1 . VAL A 1 294 ? 10.29348  14.96582  -24.98981 1.000 37.94782 ? 296 VAL A CG1 1 
ATOM   2225 C CG2 . VAL A 1 294 ? 8.50284   13.18828  -25.23650 1.000 29.56277 ? 296 VAL A CG2 1 
ATOM   2226 N N   . VAL A 1 295 ? 8.16995   17.67945  -24.28651 1.000 39.03623 ? 297 VAL A N   1 
ATOM   2227 C CA  . VAL A 1 295 ? 8.60706   19.03932  -23.97904 1.000 44.07123 ? 297 VAL A CA  1 
ATOM   2228 C C   . VAL A 1 295 ? 8.19069   19.42798  -22.56362 1.000 47.03164 ? 297 VAL A C   1 
ATOM   2229 O O   . VAL A 1 295 ? 8.93689   20.11712  -21.85540 1.000 54.09543 ? 297 VAL A O   1 
ATOM   2230 C CB  . VAL A 1 295 ? 8.06117   20.02440  -25.03366 1.000 43.66949 ? 297 VAL A CB  1 
ATOM   2231 C CG1 . VAL A 1 295 ? 8.18970   21.45839  -24.55487 1.000 45.02122 ? 297 VAL A CG1 1 
ATOM   2232 C CG2 . VAL A 1 295 ? 8.79391   19.84565  -26.35374 1.000 38.86626 ? 297 VAL A CG2 1 
ATOM   2233 N N   . ARG A 1 296 ? 7.02156   18.96908  -22.11663 1.000 46.79602 ? 298 ARG A N   1 
ATOM   2234 C CA  . ARG A 1 296 ? 6.57663   19.19264  -20.74160 1.000 50.20195 ? 298 ARG A CA  1 
ATOM   2235 C C   . ARG A 1 296 ? 7.49117   18.48480  -19.73595 1.000 51.53892 ? 298 ARG A C   1 
ATOM   2236 O O   . ARG A 1 296 ? 7.49994   17.25319  -19.63516 1.000 53.66056 ? 298 ARG A O   1 
ATOM   2237 C CB  . ARG A 1 296 ? 5.13100   18.72054  -20.56437 1.000 47.25850 ? 298 ARG A CB  1 
ATOM   2238 N N   . PHE B 1 1   ? -5.31878  -5.86979  -23.73609 1.000 66.79833 ? 3   PHE B N   1 
ATOM   2239 C CA  . PHE B 1 1   ? -5.03745  -6.10029  -22.32044 1.000 60.66243 ? 3   PHE B CA  1 
ATOM   2240 C C   . PHE B 1 1   ? -4.05228  -5.06571  -21.76437 1.000 62.92862 ? 3   PHE B C   1 
ATOM   2241 O O   . PHE B 1 1   ? -2.85272  -5.33404  -21.64945 1.000 58.19444 ? 3   PHE B O   1 
ATOM   2242 C CB  . PHE B 1 1   ? -4.49302  -7.51913  -22.10594 1.000 56.44181 ? 3   PHE B CB  1 
ATOM   2243 C CG  . PHE B 1 1   ? -4.83045  -8.10390  -20.75598 1.000 55.43412 ? 3   PHE B CG  1 
ATOM   2244 C CD1 . PHE B 1 1   ? -6.10767  -8.57260  -20.48865 1.000 53.47056 ? 3   PHE B CD1 1 
ATOM   2245 C CD2 . PHE B 1 1   ? -3.86909  -8.17727  -19.75473 1.000 52.52662 ? 3   PHE B CD2 1 
ATOM   2246 C CE1 . PHE B 1 1   ? -6.42486  -9.10053  -19.25070 1.000 53.18109 ? 3   PHE B CE1 1 
ATOM   2247 C CE2 . PHE B 1 1   ? -4.17887  -8.70541  -18.51390 1.000 49.57939 ? 3   PHE B CE2 1 
ATOM   2248 C CZ  . PHE B 1 1   ? -5.46011  -9.16543  -18.26118 1.000 50.60097 ? 3   PHE B CZ  1 
ATOM   2249 N N   . ARG B 1 2   ? -4.57048  -3.88293  -21.43136 1.000 62.59790 ? 4   ARG B N   1 
ATOM   2250 C CA  . ARG B 1 2   ? -3.77771  -2.83482  -20.80503 1.000 52.73712 ? 4   ARG B CA  1 
ATOM   2251 C C   . ARG B 1 2   ? -3.58170  -3.12332  -19.32168 1.000 42.60101 ? 4   ARG B C   1 
ATOM   2252 O O   . ARG B 1 2   ? -4.46351  -3.66123  -18.64587 1.000 48.63526 ? 4   ARG B O   1 
ATOM   2253 C CB  . ARG B 1 2   ? -4.45982  -1.46481  -20.94636 1.000 53.59252 ? 4   ARG B CB  1 
ATOM   2254 C CG  . ARG B 1 2   ? -4.37683  -0.80743  -22.31055 1.000 49.20866 ? 4   ARG B CG  1 
ATOM   2255 C CD  . ARG B 1 2   ? -3.45236  0.41993   -22.30743 1.000 44.31889 ? 4   ARG B CD  1 
ATOM   2256 N NE  . ARG B 1 2   ? -3.39547  1.00504   -23.64267 1.000 45.84486 ? 4   ARG B NE  1 
ATOM   2257 C CZ  . ARG B 1 2   ? -2.40198  1.75747   -24.09785 1.000 40.47845 ? 4   ARG B CZ  1 
ATOM   2258 N NH1 . ARG B 1 2   ? -1.37002  2.03492   -23.32105 1.000 43.33129 ? 4   ARG B NH1 1 
ATOM   2259 N NH2 . ARG B 1 2   ? -2.44408  2.22925   -25.33457 1.000 42.11634 ? 4   ARG B NH2 1 
ATOM   2260 N N   . LYS B 1 3   ? -2.41003  -2.75719  -18.82180 1.000 42.39195 ? 5   LYS B N   1 
ATOM   2261 C CA  . LYS B 1 3   ? -2.25087  -2.51661  -17.39660 1.000 41.10966 ? 5   LYS B CA  1 
ATOM   2262 C C   . LYS B 1 3   ? -3.10866  -1.31242  -17.01700 1.000 38.99405 ? 5   LYS B C   1 
ATOM   2263 O O   . LYS B 1 3   ? -3.09174  -0.28846  -17.70911 1.000 41.40081 ? 5   LYS B O   1 
ATOM   2264 C CB  . LYS B 1 3   ? -0.77516  -2.26520  -17.07282 1.000 41.73580 ? 5   LYS B CB  1 
ATOM   2265 C CG  . LYS B 1 3   ? -0.35639  -2.68123  -15.67539 1.000 39.43375 ? 5   LYS B CG  1 
ATOM   2266 C CD  . LYS B 1 3   ? 1.10218   -3.12719  -15.61745 1.000 41.67277 ? 5   LYS B CD  1 
ATOM   2267 C CE  . LYS B 1 3   ? 2.07744   -1.94940  -15.69046 1.000 46.13132 ? 5   LYS B CE  1 
ATOM   2268 N NZ  . LYS B 1 3   ? 3.38072   -2.25948  -14.98521 1.000 44.21164 ? 5   LYS B NZ  1 
ATOM   2269 N N   . MET B 1 4   ? -3.90487  -1.44018  -15.96203 1.000 31.60950 ? 6   MET B N   1 
ATOM   2270 C CA  . MET B 1 4   ? -4.68882  -0.31451  -15.47063 1.000 28.93055 ? 6   MET B CA  1 
ATOM   2271 C C   . MET B 1 4   ? -4.29702  -0.00706  -14.03304 1.000 24.04482 ? 6   MET B C   1 
ATOM   2272 O O   . MET B 1 4   ? -4.10534  -0.91878  -13.22336 1.000 25.61716 ? 6   MET B O   1 
ATOM   2273 C CB  . MET B 1 4   ? -6.20867  -0.58569  -15.53576 1.000 29.41658 ? 6   MET B CB  1 
ATOM   2274 C CG  . MET B 1 4   ? -6.77172  -0.74017  -16.94085 1.000 33.64898 ? 6   MET B CG  1 
ATOM   2275 S SD  . MET B 1 4   ? -8.56452  -0.45627  -16.96935 1.000 34.67906 ? 6   MET B SD  1 
ATOM   2276 C CE  . MET B 1 4   ? -9.11582  -1.74294  -15.85146 1.000 36.64159 ? 6   MET B CE  1 
ATOM   2277 N N   . ALA B 1 5   ? -4.20866  1.28012   -13.72223 1.000 25.98781 ? 7   ALA B N   1 
ATOM   2278 C CA  . ALA B 1 5   ? -4.11618  1.75719   -12.35204 1.000 23.43621 ? 7   ALA B CA  1 
ATOM   2279 C C   . ALA B 1 5   ? -5.50827  1.82847   -11.73778 1.000 26.98498 ? 7   ALA B C   1 
ATOM   2280 O O   . ALA B 1 5   ? -6.51357  1.89319   -12.44843 1.000 23.58506 ? 7   ALA B O   1 
ATOM   2281 C CB  . ALA B 1 5   ? -3.47386  3.14225   -12.30421 1.000 22.65036 ? 7   ALA B CB  1 
ATOM   2282 N N   . PHE B 1 6   ? -5.56316  1.85404   -10.40352 1.000 24.07164 ? 8   PHE B N   1 
ATOM   2283 C CA  . PHE B 1 6   ? -6.84432  2.09199   -9.75463  1.000 23.67524 ? 8   PHE B CA  1 
ATOM   2284 C C   . PHE B 1 6   ? -7.24579  3.55761   -9.92221  1.000 23.60883 ? 8   PHE B C   1 
ATOM   2285 O O   . PHE B 1 6   ? -6.39012  4.43752   -10.03455 1.000 25.04330 ? 8   PHE B O   1 
ATOM   2286 C CB  . PHE B 1 6   ? -6.79410  1.73511   -8.26581  1.000 25.59149 ? 8   PHE B CB  1 
ATOM   2287 C CG  . PHE B 1 6   ? -6.68042  0.26269   -8.00013  1.000 28.54865 ? 8   PHE B CG  1 
ATOM   2288 C CD1 . PHE B 1 6   ? -7.79537  -0.55637  -8.07570  1.000 28.49346 ? 8   PHE B CD1 1 
ATOM   2289 C CD2 . PHE B 1 6   ? -5.44619  -0.31031  -7.71548  1.000 24.63272 ? 8   PHE B CD2 1 
ATOM   2290 C CE1 . PHE B 1 6   ? -7.69154  -1.91393  -7.84376  1.000 32.87022 ? 8   PHE B CE1 1 
ATOM   2291 C CE2 . PHE B 1 6   ? -5.34106  -1.66720  -7.49044  1.000 28.03158 ? 8   PHE B CE2 1 
ATOM   2292 C CZ  . PHE B 1 6   ? -6.46442  -2.46999  -7.54189  1.000 28.96859 ? 8   PHE B CZ  1 
ATOM   2293 N N   . PRO B 1 7   ? -8.54468  3.85076   -9.95484  1.000 23.54612 ? 9   PRO B N   1 
ATOM   2294 C CA  . PRO B 1 7   ? -8.96489  5.25791   -9.91836  1.000 22.98232 ? 9   PRO B CA  1 
ATOM   2295 C C   . PRO B 1 7   ? -8.40943  5.93674   -8.66803  1.000 22.06012 ? 9   PRO B C   1 
ATOM   2296 O O   . PRO B 1 7   ? -8.47994  5.39581   -7.56144  1.000 23.89272 ? 9   PRO B O   1 
ATOM   2297 C CB  . PRO B 1 7   ? -10.50048 5.17723   -9.90057  1.000 27.01607 ? 9   PRO B CB  1 
ATOM   2298 C CG  . PRO B 1 7   ? -10.84227 3.77142   -10.37168 1.000 25.28471 ? 9   PRO B CG  1 
ATOM   2299 C CD  . PRO B 1 7   ? -9.67851  2.91496   -9.91392  1.000 24.00593 ? 9   PRO B CD  1 
ATOM   2300 N N   . SER B 1 8   ? -7.84427  7.12334   -8.84535  1.000 23.69060 ? 10  SER B N   1 
ATOM   2301 C CA  . SER B 1 8   ? -7.02617  7.72562   -7.79607  1.000 23.45119 ? 10  SER B CA  1 
ATOM   2302 C C   . SER B 1 8   ? -7.76914  8.75579   -6.95800  1.000 26.66588 ? 10  SER B C   1 
ATOM   2303 O O   . SER B 1 8   ? -7.18392  9.30424   -6.01707  1.000 23.59370 ? 10  SER B O   1 
ATOM   2304 C CB  . SER B 1 8   ? -5.78081  8.36583   -8.40615  1.000 25.94919 ? 10  SER B CB  1 
ATOM   2305 O OG  . SER B 1 8   ? -6.14580  9.37727   -9.33279  1.000 25.60559 ? 10  SER B OG  1 
ATOM   2306 N N   . GLY B 1 9   ? -9.04553  9.00769   -7.25617  1.000 25.27547 ? 11  GLY B N   1 
ATOM   2307 C CA  . GLY B 1 9   ? -9.75479  10.08642  -6.59373  1.000 24.49060 ? 11  GLY B CA  1 
ATOM   2308 C C   . GLY B 1 9   ? -9.73245  9.99958   -5.08035  1.000 25.33558 ? 11  GLY B C   1 
ATOM   2309 O O   . GLY B 1 9   ? -9.52418  11.00660  -4.40470  1.000 28.24310 ? 11  GLY B O   1 
ATOM   2310 N N   . LYS B 1 10  ? -9.94042  8.80077   -4.52466  1.000 25.05484 ? 12  LYS B N   1 
ATOM   2311 C CA  . LYS B 1 10  ? -9.98234  8.66979   -3.06671  1.000 25.29106 ? 12  LYS B CA  1 
ATOM   2312 C C   . LYS B 1 10  ? -8.65202  9.05460   -2.42887  1.000 27.34835 ? 12  LYS B C   1 
ATOM   2313 O O   . LYS B 1 10  ? -8.62527  9.54860   -1.29231  1.000 27.42898 ? 12  LYS B O   1 
ATOM   2314 C CB  . LYS B 1 10  ? -10.36401 7.24451   -2.66290  1.000 24.14567 ? 12  LYS B CB  1 
ATOM   2315 C CG  . LYS B 1 10  ? -11.83116 6.92361   -2.91534  1.000 26.37655 ? 12  LYS B CG  1 
ATOM   2316 C CD  . LYS B 1 10  ? -12.12979 5.47848   -2.58781  1.000 30.61576 ? 12  LYS B CD  1 
ATOM   2317 C CE  . LYS B 1 10  ? -13.63506 5.25200   -2.49629  1.000 38.25912 ? 12  LYS B CE  1 
ATOM   2318 N NZ  . LYS B 1 10  ? -14.21294 5.12498   -3.84320  1.000 38.31870 ? 12  LYS B NZ  1 
ATOM   2319 N N   . VAL B 1 11  ? -7.54873  8.84958   -3.14548  1.000 23.98262 ? 13  VAL B N   1 
ATOM   2320 C CA  . VAL B 1 11  ? -6.24029  9.18790   -2.60101  1.000 25.44825 ? 13  VAL B CA  1 
ATOM   2321 C C   . VAL B 1 11  ? -5.91814  10.65269  -2.85543  1.000 25.57050 ? 13  VAL B C   1 
ATOM   2322 O O   . VAL B 1 11  ? -5.27603  11.30538  -2.02448  1.000 26.25574 ? 13  VAL B O   1 
ATOM   2323 C CB  . VAL B 1 11  ? -5.17164  8.24889   -3.19327  1.000 25.48229 ? 13  VAL B CB  1 
ATOM   2324 C CG1 . VAL B 1 11  ? -3.77132  8.56901   -2.62057  1.000 26.89889 ? 13  VAL B CG1 1 
ATOM   2325 C CG2 . VAL B 1 11  ? -5.55755  6.80894   -2.91435  1.000 25.20955 ? 13  VAL B CG2 1 
ATOM   2326 N N   . GLU B 1 12  ? -6.37718  11.19859  -3.98472  1.000 27.61235 ? 14  GLU B N   1 
ATOM   2327 C CA  . GLU B 1 12  ? -6.08153  12.59005  -4.31363  1.000 29.11828 ? 14  GLU B CA  1 
ATOM   2328 C C   . GLU B 1 12  ? -6.53896  13.52281  -3.20682  1.000 25.44311 ? 14  GLU B C   1 
ATOM   2329 O O   . GLU B 1 12  ? -5.85492  14.49814  -2.88901  1.000 29.21143 ? 14  GLU B O   1 
ATOM   2330 C CB  . GLU B 1 12  ? -6.75856  12.98206  -5.62489  1.000 29.81584 ? 14  GLU B CB  1 
ATOM   2331 C CG  . GLU B 1 12  ? -6.10739  12.43812  -6.89150  1.000 27.64456 ? 14  GLU B CG  1 
ATOM   2332 C CD  . GLU B 1 12  ? -7.07076  12.52056  -8.08143  1.000 26.11991 ? 14  GLU B CD  1 
ATOM   2333 O OE1 . GLU B 1 12  ? -7.37962  11.46545  -8.68864  1.000 25.67486 ? 14  GLU B OE1 1 
ATOM   2334 O OE2 . GLU B 1 12  ? -7.50627  13.65059  -8.40805  1.000 27.25735 ? 14  GLU B OE2 1 
ATOM   2335 N N   . GLY B 1 13  ? -7.68984  13.23205  -2.60872  1.000 28.65891 ? 15  GLY B N   1 
ATOM   2336 C CA  . GLY B 1 13  ? -8.22154  14.02082  -1.51870  1.000 31.43487 ? 15  GLY B CA  1 
ATOM   2337 C C   . GLY B 1 13  ? -7.43945  13.92424  -0.22707  1.000 30.28891 ? 15  GLY B C   1 
ATOM   2338 O O   . GLY B 1 13  ? -7.79636  14.59825  0.73875   1.000 31.43207 ? 15  GLY B O   1 
ATOM   2339 N N   . CYS B 1 14  ? -6.38463  13.11422  -0.18092  1.000 29.32265 ? 16  CYS B N   1 
ATOM   2340 C CA  . CYS B 1 14  ? -5.56573  12.97015  1.01829   1.000 29.54914 ? 16  CYS B CA  1 
ATOM   2341 C C   . CYS B 1 14  ? -4.16818  13.55060  0.87331   1.000 31.40397 ? 16  CYS B C   1 
ATOM   2342 O O   . CYS B 1 14  ? -3.40461  13.53995  1.84800   1.000 29.30982 ? 16  CYS B O   1 
ATOM   2343 C CB  . CYS B 1 14  ? -5.44134  11.49716  1.40377   1.000 27.05656 ? 16  CYS B CB  1 
ATOM   2344 S SG  . CYS B 1 14  ? -7.00227  10.66654  1.62935   1.000 31.11521 ? 16  CYS B SG  1 
ATOM   2345 N N   . MET B 1 15  ? -3.79792  14.03822  -0.30270  1.000 26.91823 ? 17  MET B N   1 
ATOM   2346 C CA  . MET B 1 15  ? -2.42751  14.47843  -0.50921  1.000 30.26002 ? 17  MET B CA  1 
ATOM   2347 C C   . MET B 1 15  ? -2.26103  15.91216  -0.02730  1.000 34.40726 ? 17  MET B C   1 
ATOM   2348 O O   . MET B 1 15  ? -3.07741  16.78561  -0.34388  1.000 31.99477 ? 17  MET B O   1 
ATOM   2349 C CB  . MET B 1 15  ? -2.03777  14.35727  -1.97633  1.000 29.24292 ? 17  MET B CB  1 
ATOM   2350 C CG  . MET B 1 15  ? -2.07234  12.91942  -2.49052  1.000 31.00791 ? 17  MET B CG  1 
ATOM   2351 S SD  . MET B 1 15  ? -1.25646  11.73561  -1.39751  1.000 30.39570 ? 17  MET B SD  1 
ATOM   2352 C CE  . MET B 1 15  ? 0.42541   12.38688  -1.35139  1.000 29.79220 ? 17  MET B CE  1 
ATOM   2353 N N   . VAL B 1 16  ? -1.20861  16.14855  0.75528   1.000 30.44062 ? 18  VAL B N   1 
ATOM   2354 C CA  . VAL B 1 16  ? -0.89424  17.47387  1.25922   1.000 31.37949 ? 18  VAL B CA  1 
ATOM   2355 C C   . VAL B 1 16  ? 0.59182   17.73206  1.06654   1.000 32.86501 ? 18  VAL B C   1 
ATOM   2356 O O   . VAL B 1 16  ? 1.36896   16.84024  0.72079   1.000 30.65553 ? 18  VAL B O   1 
ATOM   2357 C CB  . VAL B 1 16  ? -1.30045  17.65576  2.74032   1.000 31.34645 ? 18  VAL B CB  1 
ATOM   2358 C CG1 . VAL B 1 16  ? -2.80342  17.43401  2.91686   1.000 34.88531 ? 18  VAL B CG1 1 
ATOM   2359 C CG2 . VAL B 1 16  ? -0.49633  16.73188  3.65104   1.000 31.17087 ? 18  VAL B CG2 1 
ATOM   2360 N N   . GLN B 1 17  ? 0.96968   18.98735  1.26802   1.000 33.71190 ? 19  GLN B N   1 
ATOM   2361 C CA  . GLN B 1 17  ? 2.35759   19.42170  1.21124   1.000 38.60196 ? 19  GLN B CA  1 
ATOM   2362 C C   . GLN B 1 17  ? 2.88403   19.59522  2.63409   1.000 33.48850 ? 19  GLN B C   1 
ATOM   2363 O O   . GLN B 1 17  ? 2.18673   20.13269  3.50017   1.000 33.64410 ? 19  GLN B O   1 
ATOM   2364 C CB  . GLN B 1 17  ? 2.45429   20.73090  0.42424   1.000 38.41831 ? 19  GLN B CB  1 
ATOM   2365 C CG  . GLN B 1 17  ? 3.83860   21.26552  0.21849   1.000 39.08260 ? 19  GLN B CG  1 
ATOM   2366 C CD  . GLN B 1 17  ? 3.83199   22.56897  -0.55484  1.000 41.78599 ? 19  GLN B CD  1 
ATOM   2367 O OE1 . GLN B 1 17  ? 4.77211   22.87290  -1.27823  1.000 51.18665 ? 19  GLN B OE1 1 
ATOM   2368 N NE2 . GLN B 1 17  ? 2.76032   23.33993  -0.41279  1.000 46.44674 ? 19  GLN B NE2 1 
ATOM   2369 N N   . VAL B 1 18  ? 4.09374   19.09664  2.88305   1.000 33.50145 ? 20  VAL B N   1 
ATOM   2370 C CA  . VAL B 1 18  ? 4.71928   19.15550  4.20249   1.000 31.19941 ? 20  VAL B CA  1 
ATOM   2371 C C   . VAL B 1 18  ? 6.09348   19.79404  4.05180   1.000 36.15611 ? 20  VAL B C   1 
ATOM   2372 O O   . VAL B 1 18  ? 6.92240   19.31225  3.27110   1.000 33.81959 ? 20  VAL B O   1 
ATOM   2373 C CB  . VAL B 1 18  ? 4.85149   17.76313  4.85018   1.000 33.49194 ? 20  VAL B CB  1 
ATOM   2374 C CG1 . VAL B 1 18  ? 5.47810   17.87820  6.23012   1.000 33.54393 ? 20  VAL B CG1 1 
ATOM   2375 C CG2 . VAL B 1 18  ? 3.49773   17.06738  4.93460   1.000 29.61364 ? 20  VAL B CG2 1 
ATOM   2376 N N   . THR B 1 19  ? 6.33856   20.86300  4.81157   1.000 33.86314 ? 21  THR B N   1 
ATOM   2377 C CA  . THR B 1 19  ? 7.58398   21.61066  4.72481   1.000 40.03985 ? 21  THR B CA  1 
ATOM   2378 C C   . THR B 1 19  ? 8.21239   21.69621  6.10602   1.000 33.29068 ? 21  THR B C   1 
ATOM   2379 O O   . THR B 1 19  ? 7.53832   22.02886  7.08419   1.000 37.24704 ? 21  THR B O   1 
ATOM   2380 C CB  . THR B 1 19  ? 7.34956   23.01379  4.13917   1.000 40.69992 ? 21  THR B CB  1 
ATOM   2381 O OG1 . THR B 1 19  ? 6.87177   22.89088  2.79237   1.000 42.01455 ? 21  THR B OG1 1 
ATOM   2382 C CG2 . THR B 1 19  ? 8.64432   23.82141  4.12430   1.000 41.43877 ? 21  THR B CG2 1 
ATOM   2383 N N   . CYS B 1 20  ? 9.49250   21.36253  6.18677   1.000 37.41986 ? 22  CYS B N   1 
ATOM   2384 C CA  . CYS B 1 20  ? 10.25420  21.49784  7.41910   1.000 37.02947 ? 22  CYS B CA  1 
ATOM   2385 C C   . CYS B 1 20  ? 11.56906  22.16418  7.05481   1.000 42.59751 ? 22  CYS B C   1 
ATOM   2386 O O   . CYS B 1 20  ? 12.39131  21.57481  6.34090   1.000 41.10435 ? 22  CYS B O   1 
ATOM   2387 C CB  . CYS B 1 20  ? 10.47310  20.14691  8.09683   1.000 35.73280 ? 22  CYS B CB  1 
ATOM   2388 S SG  . CYS B 1 20  ? 11.25862  20.29102  9.71787   1.000 43.05634 ? 22  CYS B SG  1 
ATOM   2389 N N   . GLY B 1 21  ? 11.75200  23.39314  7.52653   1.000 41.91413 ? 23  GLY B N   1 
ATOM   2390 C CA  . GLY B 1 21  ? 12.94042  24.14970  7.16150   1.000 43.14482 ? 23  GLY B CA  1 
ATOM   2391 C C   . GLY B 1 21  ? 12.93764  24.44018  5.67205   1.000 43.16656 ? 23  GLY B C   1 
ATOM   2392 O O   . GLY B 1 21  ? 12.03718  25.09886  5.14117   1.000 46.22184 ? 23  GLY B O   1 
ATOM   2393 N N   . THR B 1 22  ? 13.94879  23.93486  4.97368   1.000 48.95025 ? 24  THR B N   1 
ATOM   2394 C CA  . THR B 1 22  ? 14.09571  24.16469  3.54178   1.000 46.26528 ? 24  THR B CA  1 
ATOM   2395 C C   . THR B 1 22  ? 13.54645  23.02258  2.69412   1.000 48.63765 ? 24  THR B C   1 
ATOM   2396 O O   . THR B 1 22  ? 13.50439  23.14989  1.46464   1.000 48.55173 ? 24  THR B O   1 
ATOM   2397 C CB  . THR B 1 22  ? 15.57647  24.39562  3.19879   1.000 46.98207 ? 24  THR B CB  1 
ATOM   2398 O OG1 . THR B 1 22  ? 15.70544  24.68679  1.80369   1.000 59.05204 ? 24  THR B OG1 1 
ATOM   2399 C CG2 . THR B 1 22  ? 16.40588  23.16238  3.51906   1.000 45.44275 ? 24  THR B CG2 1 
ATOM   2400 N N   . THR B 1 23  ? 13.11620  21.92692  3.32060   1.000 47.00173 ? 25  THR B N   1 
ATOM   2401 C CA  . THR B 1 23  ? 12.69173  20.71229  2.63640   1.000 41.01533 ? 25  THR B CA  1 
ATOM   2402 C C   . THR B 1 23  ? 11.17207  20.67028  2.53649   1.000 41.12197 ? 25  THR B C   1 
ATOM   2403 O O   . THR B 1 23  ? 10.48101  20.87519  3.53570   1.000 39.31642 ? 25  THR B O   1 
ATOM   2404 C CB  . THR B 1 23  ? 13.18989  19.48131  3.39204   1.000 43.45299 ? 25  THR B CB  1 
ATOM   2405 O OG1 . THR B 1 23  ? 14.62115  19.50433  3.45385   1.000 46.66579 ? 25  THR B OG1 1 
ATOM   2406 C CG2 . THR B 1 23  ? 12.71273  18.19433  2.71199   1.000 42.39488 ? 25  THR B CG2 1 
ATOM   2407 N N   . THR B 1 24  ? 10.66137  20.40577  1.32971   1.000 41.04180 ? 26  THR B N   1 
ATOM   2408 C CA  . THR B 1 24  ? 9.23584   20.23301  1.06895   1.000 39.18880 ? 26  THR B CA  1 
ATOM   2409 C C   . THR B 1 24  ? 9.01886   18.88347  0.39816   1.000 38.38081 ? 26  THR B C   1 
ATOM   2410 O O   . THR B 1 24  ? 9.75775   18.53006  -0.52622  1.000 36.49360 ? 26  THR B O   1 
ATOM   2411 C CB  . THR B 1 24  ? 8.69436   21.34962  0.16237   1.000 41.58603 ? 26  THR B CB  1 
ATOM   2412 O OG1 . THR B 1 24  ? 8.69936   22.59635  0.86309   1.000 47.06706 ? 26  THR B OG1 1 
ATOM   2413 C CG2 . THR B 1 24  ? 7.27657   21.04601  -0.27619  1.000 41.70418 ? 26  THR B CG2 1 
ATOM   2414 N N   . LEU B 1 25  ? 8.01395   18.13353  0.84972   1.000 36.03723 ? 27  LEU B N   1 
ATOM   2415 C CA  . LEU B 1 25  ? 7.66530   16.88002  0.18745   1.000 31.49840 ? 27  LEU B CA  1 
ATOM   2416 C C   . LEU B 1 25  ? 6.17372   16.62419  0.37827   1.000 31.16663 ? 27  LEU B C   1 
ATOM   2417 O O   . LEU B 1 25  ? 5.44229   17.46114  0.91671   1.000 32.06326 ? 27  LEU B O   1 
ATOM   2418 C CB  . LEU B 1 25  ? 8.52688   15.71451  0.69894   1.000 27.95379 ? 27  LEU B CB  1 
ATOM   2419 C CG  . LEU B 1 25  ? 8.81247   15.50995  2.19248   1.000 30.18182 ? 27  LEU B CG  1 
ATOM   2420 C CD1 . LEU B 1 25  ? 7.53978   15.17529  2.97920   1.000 31.00715 ? 27  LEU B CD1 1 
ATOM   2421 C CD2 . LEU B 1 25  ? 9.87359   14.42896  2.39158   1.000 29.32287 ? 27  LEU B CD2 1 
ATOM   2422 N N   . ASN B 1 26  ? 5.72302   15.45424  -0.06030  1.000 30.34968 ? 28  ASN B N   1 
ATOM   2423 C CA  . ASN B 1 26  ? 4.31304   15.09701  0.01159   1.000 30.14281 ? 28  ASN B CA  1 
ATOM   2424 C C   . ASN B 1 26  ? 3.99934   14.36436  1.31095   1.000 29.67385 ? 28  ASN B C   1 
ATOM   2425 O O   . ASN B 1 26  ? 4.82457   13.61197  1.83390   1.000 29.02409 ? 28  ASN B O   1 
ATOM   2426 C CB  . ASN B 1 26  ? 3.91536   14.21369  -1.17524  1.000 28.38252 ? 28  ASN B CB  1 
ATOM   2427 C CG  . ASN B 1 26  ? 4.27151   14.83210  -2.50742  1.000 31.27202 ? 28  ASN B CG  1 
ATOM   2428 O OD1 . ASN B 1 26  ? 3.62635   15.77633  -2.95129  1.000 32.48828 ? 28  ASN B OD1 1 
ATOM   2429 N ND2 . ASN B 1 26  ? 5.29487   14.29175  -3.16426  1.000 32.42515 ? 28  ASN B ND2 1 
ATOM   2430 N N   . GLY B 1 27  ? 2.78351   14.58626  1.81634   1.000 26.40080 ? 29  GLY B N   1 
ATOM   2431 C CA  . GLY B 1 27  ? 2.28957   13.86513  2.96879   1.000 27.84700 ? 29  GLY B CA  1 
ATOM   2432 C C   . GLY B 1 27  ? 0.89284   13.33617  2.71666   1.000 27.11661 ? 29  GLY B C   1 
ATOM   2433 O O   . GLY B 1 27  ? 0.19789   13.76415  1.79451   1.000 26.88002 ? 29  GLY B O   1 
ATOM   2434 N N   . LEU B 1 28  ? 0.48364   12.38364  3.56071   1.000 26.17664 ? 30  LEU B N   1 
ATOM   2435 C CA  . LEU B 1 28  ? -0.80532  11.69826  3.44756   1.000 23.93911 ? 30  LEU B CA  1 
ATOM   2436 C C   . LEU B 1 28  ? -1.66641  12.03397  4.65885   1.000 27.52774 ? 30  LEU B C   1 
ATOM   2437 O O   . LEU B 1 28  ? -1.31424  11.67506  5.78646   1.000 26.05946 ? 30  LEU B O   1 
ATOM   2438 C CB  . LEU B 1 28  ? -0.61504  10.17993  3.34460   1.000 22.80037 ? 30  LEU B CB  1 
ATOM   2439 C CG  . LEU B 1 28  ? -1.89783  9.37058   3.10484   1.000 25.17070 ? 30  LEU B CG  1 
ATOM   2440 C CD1 . LEU B 1 28  ? -2.45319  9.64089   1.70275   1.000 24.79423 ? 30  LEU B CD1 1 
ATOM   2441 C CD2 . LEU B 1 28  ? -1.60389  7.88264   3.29779   1.000 25.80169 ? 30  LEU B CD2 1 
ATOM   2442 N N   . TRP B 1 29  ? -2.82613  12.65735  4.41764   1.000 26.96248 ? 31  TRP B N   1 
ATOM   2443 C CA  . TRP B 1 29  ? -3.67516  13.21590  5.47237   1.000 25.58891 ? 31  TRP B CA  1 
ATOM   2444 C C   . TRP B 1 29  ? -4.93208  12.36109  5.63573   1.000 28.23610 ? 31  TRP B C   1 
ATOM   2445 O O   . TRP B 1 29  ? -5.83902  12.40606  4.79457   1.000 30.05983 ? 31  TRP B O   1 
ATOM   2446 C CB  . TRP B 1 29  ? -4.01393  14.66698  5.13096   1.000 27.15539 ? 31  TRP B CB  1 
ATOM   2447 C CG  . TRP B 1 29  ? -4.92114  15.39621  6.09156   1.000 31.44428 ? 31  TRP B CG  1 
ATOM   2448 C CD1 . TRP B 1 29  ? -5.04486  15.18782  7.43243   1.000 27.82175 ? 31  TRP B CD1 1 
ATOM   2449 C CD2 . TRP B 1 29  ? -5.80915  16.47282  5.76618   1.000 33.48760 ? 31  TRP B CD2 1 
ATOM   2450 N NE1 . TRP B 1 29  ? -5.97113  16.06502  7.96417   1.000 37.72248 ? 31  TRP B NE1 1 
ATOM   2451 C CE2 . TRP B 1 29  ? -6.45587  16.85910  6.96002   1.000 36.45699 ? 31  TRP B CE2 1 
ATOM   2452 C CE3 . TRP B 1 29  ? -6.13547  17.13477  4.57588   1.000 35.89282 ? 31  TRP B CE3 1 
ATOM   2453 C CZ2 . TRP B 1 29  ? -7.39896  17.88849  7.00081   1.000 37.09935 ? 31  TRP B CZ2 1 
ATOM   2454 C CZ3 . TRP B 1 29  ? -7.07615  18.15588  4.61692   1.000 34.59349 ? 31  TRP B CZ3 1 
ATOM   2455 C CH2 . TRP B 1 29  ? -7.69398  18.51971  5.82296   1.000 37.47913 ? 31  TRP B CH2 1 
ATOM   2456 N N   . LEU B 1 30  ? -4.98072  11.60142  6.72511   1.000 26.21006 ? 32  LEU B N   1 
ATOM   2457 C CA  . LEU B 1 30  ? -6.05372  10.67331  7.05353   1.000 28.40075 ? 32  LEU B CA  1 
ATOM   2458 C C   . LEU B 1 30  ? -6.53206  10.97157  8.47281   1.000 31.71979 ? 32  LEU B C   1 
ATOM   2459 O O   . LEU B 1 30  ? -5.71687  11.03191  9.39940   1.000 30.16318 ? 32  LEU B O   1 
ATOM   2460 C CB  . LEU B 1 30  ? -5.57308  9.21253   6.94685   1.000 24.97454 ? 32  LEU B CB  1 
ATOM   2461 C CG  . LEU B 1 30  ? -5.00892  8.73850   5.59321   1.000 26.86783 ? 32  LEU B CG  1 
ATOM   2462 C CD1 . LEU B 1 30  ? -4.34309  7.37021   5.71245   1.000 24.56611 ? 32  LEU B CD1 1 
ATOM   2463 C CD2 . LEU B 1 30  ? -6.10260  8.69852   4.53868   1.000 26.74557 ? 32  LEU B CD2 1 
ATOM   2464 N N   . ASP B 1 31  ? -7.84497  11.15492  8.65579   1.000 35.15522 ? 33  ASP B N   1 
ATOM   2465 C CA  . ASP B 1 31  ? -8.35864  11.62106  9.96148   1.000 31.96546 ? 33  ASP B CA  1 
ATOM   2466 C C   . ASP B 1 31  ? -7.62201  12.92392  10.28105  1.000 33.53732 ? 33  ASP B C   1 
ATOM   2467 O O   . ASP B 1 31  ? -7.46965  13.77953  9.39587   1.000 34.25850 ? 33  ASP B O   1 
ATOM   2468 C CB  . ASP B 1 31  ? -8.19959  10.53859  11.03640  1.000 33.16832 ? 33  ASP B CB  1 
ATOM   2469 C CG  . ASP B 1 31  ? -8.54600  9.13156   10.55045  1.000 40.97101 ? 33  ASP B CG  1 
ATOM   2470 O OD1 . ASP B 1 31  ? -9.68709  8.94358   10.11492  1.000 33.71836 ? 33  ASP B OD1 1 
ATOM   2471 O OD2 . ASP B 1 31  ? -7.67787  8.20588   10.64230  1.000 41.16448 ? 33  ASP B OD2 1 
ATOM   2472 N N   . ASP B 1 32  ? -7.09866  13.09099  11.49758  1.000 31.35378 ? 34  ASP B N   1 
ATOM   2473 C CA  . ASP B 1 32  ? -6.33054  14.26465  11.88153  1.000 34.99066 ? 34  ASP B CA  1 
ATOM   2474 C C   . ASP B 1 32  ? -4.83336  13.97053  12.00572  1.000 32.65902 ? 34  ASP B C   1 
ATOM   2475 O O   . ASP B 1 32  ? -4.15496  14.57878  12.83688  1.000 31.89546 ? 34  ASP B O   1 
ATOM   2476 C CB  . ASP B 1 32  ? -6.87265  14.85006  13.18818  1.000 36.35566 ? 34  ASP B CB  1 
ATOM   2477 C CG  . ASP B 1 32  ? -6.68819  13.92149  14.37858  1.000 42.37995 ? 34  ASP B CG  1 
ATOM   2478 O OD1 . ASP B 1 32  ? -6.44779  12.70755  14.18083  1.000 40.70948 ? 34  ASP B OD1 1 
ATOM   2479 O OD2 . ASP B 1 32  ? -6.79481  14.41116  15.52734  1.000 44.35832 ? 34  ASP B OD2 1 
ATOM   2480 N N   . VAL B 1 33  ? -4.29935  13.05178  11.18631  1.000 32.26151 ? 35  VAL B N   1 
ATOM   2481 C CA  . VAL B 1 33  ? -2.85951  12.77698  11.13138  1.000 27.58074 ? 35  VAL B CA  1 
ATOM   2482 C C   . VAL B 1 33  ? -2.37167  12.93783  9.69808   1.000 26.53770 ? 35  VAL B C   1 
ATOM   2483 O O   . VAL B 1 33  ? -3.05061  12.52108  8.75258   1.000 27.61794 ? 35  VAL B O   1 
ATOM   2484 C CB  . VAL B 1 33  ? -2.49781  11.36424  11.64962  1.000 27.85158 ? 35  VAL B CB  1 
ATOM   2485 C CG1 . VAL B 1 33  ? -0.95737  11.15780  11.63816  1.000 25.40934 ? 35  VAL B CG1 1 
ATOM   2486 C CG2 . VAL B 1 33  ? -3.05837  11.12002  13.04664  1.000 32.50156 ? 35  VAL B CG2 1 
ATOM   2487 N N   . VAL B 1 34  ? -1.18264  13.52520  9.54327   1.000 27.50103 ? 36  VAL B N   1 
ATOM   2488 C CA  . VAL B 1 34  ? -0.47626  13.57497  8.26986   1.000 25.27203 ? 36  VAL B CA  1 
ATOM   2489 C C   . VAL B 1 34  ? 0.75190   12.68414  8.38012   1.000 29.47362 ? 36  VAL B C   1 
ATOM   2490 O O   . VAL B 1 34  ? 1.55361   12.82881  9.31549   1.000 29.90658 ? 36  VAL B O   1 
ATOM   2491 C CB  . VAL B 1 34  ? -0.08766  15.01266  7.88424   1.000 27.20547 ? 36  VAL B CB  1 
ATOM   2492 C CG1 . VAL B 1 34  ? 0.80599   15.01100  6.65064   1.000 28.10313 ? 36  VAL B CG1 1 
ATOM   2493 C CG2 . VAL B 1 34  ? -1.34873  15.85371  7.63218   1.000 28.83781 ? 36  VAL B CG2 1 
ATOM   2494 N N   . TYR B 1 35  ? 0.90027   11.77121  7.42667   1.000 26.82584 ? 37  TYR B N   1 
ATOM   2495 C CA  . TYR B 1 35  ? 2.02037   10.83830  7.38557   1.000 24.45445 ? 37  TYR B CA  1 
ATOM   2496 C C   . TYR B 1 35  ? 2.98719   11.24544  6.28403   1.000 27.12783 ? 37  TYR B C   1 
ATOM   2497 O O   . TYR B 1 35  ? 2.56333   11.61275  5.18648   1.000 25.79309 ? 37  TYR B O   1 
ATOM   2498 C CB  . TYR B 1 35  ? 1.52750   9.40925   7.13588   1.000 24.98314 ? 37  TYR B CB  1 
ATOM   2499 C CG  . TYR B 1 35  ? 0.47982   8.92665   8.10435   1.000 27.55567 ? 37  TYR B CG  1 
ATOM   2500 C CD1 . TYR B 1 35  ? -0.86671  9.28856   7.95604   1.000 27.82233 ? 37  TYR B CD1 1 
ATOM   2501 C CD2 . TYR B 1 35  ? 0.82224   8.09688   9.16329   1.000 27.23106 ? 37  TYR B CD2 1 
ATOM   2502 C CE1 . TYR B 1 35  ? -1.83464  8.84132   8.85471   1.000 28.25970 ? 37  TYR B CE1 1 
ATOM   2503 C CE2 . TYR B 1 35  ? -0.14193  7.64760   10.06904  1.000 28.15989 ? 37  TYR B CE2 1 
ATOM   2504 C CZ  . TYR B 1 35  ? -1.45880  8.01843   9.90872   1.000 29.34745 ? 37  TYR B CZ  1 
ATOM   2505 O OH  . TYR B 1 35  ? -2.40091  7.56455   10.81437  1.000 28.40986 ? 37  TYR B OH  1 
ATOM   2506 N N   . CYS B 1 36  ? 4.28820   11.16659  6.56440   1.000 25.80017 ? 38  CYS B N   1 
ATOM   2507 C CA  . CYS B 1 36  ? 5.28250   11.52561  5.56285   1.000 25.27011 ? 38  CYS B CA  1 
ATOM   2508 C C   . CYS B 1 36  ? 6.62040   10.92476  5.97244   1.000 25.52822 ? 38  CYS B C   1 
ATOM   2509 O O   . CYS B 1 36  ? 6.77383   10.44579  7.10477   1.000 24.28222 ? 38  CYS B O   1 
ATOM   2510 C CB  . CYS B 1 36  ? 5.37919   13.05335  5.38800   1.000 26.51373 ? 38  CYS B CB  1 
ATOM   2511 S SG  . CYS B 1 36  ? 6.25660   13.94212  6.68984   1.000 30.18684 ? 38  CYS B SG  1 
ATOM   2512 N N   . PRO B 1 37  ? 7.59755   10.88767  5.06344   1.000 27.01434 ? 39  PRO B N   1 
ATOM   2513 C CA  . PRO B 1 37  ? 8.91402   10.33750  5.43135   1.000 27.25649 ? 39  PRO B CA  1 
ATOM   2514 C C   . PRO B 1 37  ? 9.56470   11.17434  6.52535   1.000 28.62823 ? 39  PRO B C   1 
ATOM   2515 O O   . PRO B 1 37  ? 9.55580   12.40752  6.47880   1.000 27.68049 ? 39  PRO B O   1 
ATOM   2516 C CB  . PRO B 1 37  ? 9.71355   10.40157  4.12220   1.000 24.69201 ? 39  PRO B CB  1 
ATOM   2517 C CG  . PRO B 1 37  ? 8.64392   10.41025  3.02298   1.000 26.34646 ? 39  PRO B CG  1 
ATOM   2518 C CD  . PRO B 1 37  ? 7.51262   11.21090  3.62139   1.000 27.03834 ? 39  PRO B CD  1 
ATOM   2519 N N   . ARG B 1 38  ? 10.12211  10.49383  7.52782   1.000 26.68915 ? 40  ARG B N   1 
ATOM   2520 C CA  . ARG B 1 38  ? 10.75412  11.23418  8.61507   1.000 30.18719 ? 40  ARG B CA  1 
ATOM   2521 C C   . ARG B 1 38  ? 11.95766  12.03882  8.14745   1.000 27.84864 ? 40  ARG B C   1 
ATOM   2522 O O   . ARG B 1 38  ? 12.32222  13.01438  8.81146   1.000 30.02112 ? 40  ARG B O   1 
ATOM   2523 C CB  . ARG B 1 38  ? 11.16774  10.29498  9.75444   1.000 27.39359 ? 40  ARG B CB  1 
ATOM   2524 C CG  . ARG B 1 38  ? 12.25548  9.28379   9.40672   1.000 26.35521 ? 40  ARG B CG  1 
ATOM   2525 C CD  . ARG B 1 38  ? 12.60510  8.42469   10.63439  1.000 27.98807 ? 40  ARG B CD  1 
ATOM   2526 N NE  . ARG B 1 38  ? 13.67038  7.48272   10.30589  1.000 29.81411 ? 40  ARG B NE  1 
ATOM   2527 C CZ  . ARG B 1 38  ? 14.32475  6.72969   11.18364  1.000 27.00877 ? 40  ARG B CZ  1 
ATOM   2528 N NH1 . ARG B 1 38  ? 14.03609  6.78525   12.48440  1.000 29.40391 ? 40  ARG B NH1 1 
ATOM   2529 N NH2 . ARG B 1 38  ? 15.28336  5.92587   10.74846  1.000 28.02702 ? 40  ARG B NH2 1 
ATOM   2530 N N   . HIS B 1 39  ? 12.56328  11.69262  7.00753   1.000 28.29289 ? 41  HIS B N   1 
ATOM   2531 C CA  . HIS B 1 39  ? 13.75365  12.45390  6.63507   1.000 32.08783 ? 41  HIS B CA  1 
ATOM   2532 C C   . HIS B 1 39  ? 13.43688  13.89520  6.25005   1.000 32.01570 ? 41  HIS B C   1 
ATOM   2533 O O   . HIS B 1 39  ? 14.36933  14.65808  5.97382   1.000 34.44757 ? 41  HIS B O   1 
ATOM   2534 C CB  . HIS B 1 39  ? 14.54536  11.73909  5.52317   1.000 30.44127 ? 41  HIS B CB  1 
ATOM   2535 C CG  . HIS B 1 39  ? 13.87638  11.71003  4.17607   1.000 31.89353 ? 41  HIS B CG  1 
ATOM   2536 N ND1 . HIS B 1 39  ? 13.61241  12.84748  3.44123   1.000 36.53494 ? 41  HIS B ND1 1 
ATOM   2537 C CD2 . HIS B 1 39  ? 13.48925  10.66797  3.40082   1.000 33.07271 ? 41  HIS B CD2 1 
ATOM   2538 C CE1 . HIS B 1 39  ? 13.06094  12.50985  2.28563   1.000 33.46115 ? 41  HIS B CE1 1 
ATOM   2539 N NE2 . HIS B 1 39  ? 12.97967  11.19248  2.23459   1.000 33.65799 ? 41  HIS B NE2 1 
ATOM   2540 N N   . VAL B 1 40  ? 12.16391  14.29727  6.27735   1.000 29.08064 ? 42  VAL B N   1 
ATOM   2541 C CA  . VAL B 1 40  ? 11.80773  15.69351  6.04412   1.000 33.65630 ? 42  VAL B CA  1 
ATOM   2542 C C   . VAL B 1 40  ? 12.41651  16.61148  7.09739   1.000 35.49279 ? 42  VAL B C   1 
ATOM   2543 O O   . VAL B 1 40  ? 12.62477  17.80488  6.84016   1.000 33.57947 ? 42  VAL B O   1 
ATOM   2544 C CB  . VAL B 1 40  ? 10.27737  15.85541  5.99900   1.000 30.78825 ? 42  VAL B CB  1 
ATOM   2545 C CG1 . VAL B 1 40  ? 9.67355   15.69329  7.37996   1.000 30.33990 ? 42  VAL B CG1 1 
ATOM   2546 C CG2 . VAL B 1 40  ? 9.90858   17.20773  5.41509   1.000 33.27825 ? 42  VAL B CG2 1 
ATOM   2547 N N   . ILE B 1 41  ? 12.69701  16.08854  8.29887   1.000 35.40204 ? 43  ILE B N   1 
ATOM   2548 C CA  . ILE B 1 41  ? 13.24470  16.92555  9.36719   1.000 32.05294 ? 43  ILE B CA  1 
ATOM   2549 C C   . ILE B 1 41  ? 14.74751  17.10459  9.25572   1.000 37.91255 ? 43  ILE B C   1 
ATOM   2550 O O   . ILE B 1 41  ? 15.32008  17.88925  10.01957  1.000 42.23688 ? 43  ILE B O   1 
ATOM   2551 C CB  . ILE B 1 41  ? 12.92225  16.36444  10.76738  1.000 31.93582 ? 43  ILE B CB  1 
ATOM   2552 C CG1 . ILE B 1 41  ? 13.70001  15.07108  11.01887  1.000 34.48742 ? 43  ILE B CG1 1 
ATOM   2553 C CG2 . ILE B 1 41  ? 11.41470  16.14580  10.93556  1.000 32.87487 ? 43  ILE B CG2 1 
ATOM   2554 C CD1 . ILE B 1 41  ? 13.59395  14.57543  12.44139  1.000 38.16753 ? 43  ILE B CD1 1 
ATOM   2555 N N   . CYS B 1 42  ? 15.39925  16.41732  8.32084   1.000 33.72603 ? 44  CYS B N   1 
ATOM   2556 C CA  . CYS B 1 42  ? 16.84912  16.44166  8.18628   1.000 43.72066 ? 44  CYS B CA  1 
ATOM   2557 C C   . CYS B 1 42  ? 17.30076  17.59030  7.29666   1.000 47.62380 ? 44  CYS B C   1 
ATOM   2558 O O   . CYS B 1 42  ? 16.79783  17.75643  6.17967   1.000 50.08490 ? 44  CYS B O   1 
ATOM   2559 C CB  . CYS B 1 42  ? 17.35788  15.12388  7.60088   1.000 39.29046 ? 44  CYS B CB  1 
ATOM   2560 S SG  . CYS B 1 42  ? 17.41130  13.80214  8.80654   1.000 46.36011 ? 44  CYS B SG  1 
ATOM   2561 N N   . THR B 1 43  ? 18.24360  18.38280  7.80585   1.000 49.37434 ? 45  THR B N   1 
ATOM   2562 C CA  . THR B 1 43  ? 19.07016  19.22096  6.95782   1.000 52.21316 ? 45  THR B CA  1 
ATOM   2563 C C   . THR B 1 43  ? 20.13550  18.35423  6.29320   1.000 51.72380 ? 45  THR B C   1 
ATOM   2564 O O   . THR B 1 43  ? 20.31972  17.17699  6.63085   1.000 53.19189 ? 45  THR B O   1 
ATOM   2565 C CB  . THR B 1 43  ? 19.71195  20.35318  7.76535   1.000 55.07197 ? 45  THR B CB  1 
ATOM   2566 O OG1 . THR B 1 43  ? 20.62108  19.80003  8.72511   1.000 54.05824 ? 45  THR B OG1 1 
ATOM   2567 C CG2 . THR B 1 43  ? 18.64354  21.16451  8.49495   1.000 50.04553 ? 45  THR B CG2 1 
ATOM   2568 N N   . SER B 1 44  ? 20.83927  18.94450  5.32521   1.000 55.99367 ? 46  SER B N   1 
ATOM   2569 C CA  . SER B 1 44  ? 21.88532  18.20051  4.62882   1.000 54.43801 ? 46  SER B CA  1 
ATOM   2570 C C   . SER B 1 44  ? 22.95734  17.71337  5.59668   1.000 55.72248 ? 46  SER B C   1 
ATOM   2571 O O   . SER B 1 44  ? 23.45483  16.59119  5.46592   1.000 59.23321 ? 46  SER B O   1 
ATOM   2572 C CB  . SER B 1 44  ? 22.49969  19.06625  3.53222   1.000 58.74870 ? 46  SER B CB  1 
ATOM   2573 O OG  . SER B 1 44  ? 22.52162  20.42504  3.92458   1.000 68.80257 ? 46  SER B OG  1 
ATOM   2574 N N   . GLU B 1 45  ? 23.31959  18.53293  6.58647   1.000 54.41239 ? 47  GLU B N   1 
ATOM   2575 C CA  . GLU B 1 45  ? 24.33177  18.10781  7.55281   1.000 61.14866 ? 47  GLU B CA  1 
ATOM   2576 C C   . GLU B 1 45  ? 23.87149  16.88576  8.34046   1.000 58.17924 ? 47  GLU B C   1 
ATOM   2577 O O   . GLU B 1 45  ? 24.67407  15.98763  8.62586   1.000 59.04920 ? 47  GLU B O   1 
ATOM   2578 C CB  . GLU B 1 45  ? 24.68559  19.25007  8.51061   1.000 62.03324 ? 47  GLU B CB  1 
ATOM   2579 C CG  . GLU B 1 45  ? 23.49849  20.09383  8.90150   1.000 64.57317 ? 47  GLU B CG  1 
ATOM   2580 C CD  . GLU B 1 45  ? 23.77912  21.08432  10.01324  1.000 69.23233 ? 47  GLU B CD  1 
ATOM   2581 O OE1 . GLU B 1 45  ? 22.80976  21.71332  10.48648  1.000 69.23812 ? 47  GLU B OE1 1 
ATOM   2582 O OE2 . GLU B 1 45  ? 24.96165  21.24261  10.39793  1.000 71.24426 ? 47  GLU B OE2 1 
ATOM   2583 N N   . ASP B 1 46  ? 22.57613  16.81565  8.67200   1.000 55.53546 ? 48  ASP B N   1 
ATOM   2584 C CA  . ASP B 1 46  ? 22.07265  15.67826  9.43687   1.000 53.08095 ? 48  ASP B CA  1 
ATOM   2585 C C   . ASP B 1 46  ? 22.04120  14.39084  8.62130   1.000 50.65502 ? 48  ASP B C   1 
ATOM   2586 O O   . ASP B 1 46  ? 22.15704  13.29931  9.19263   1.000 50.09789 ? 48  ASP B O   1 
ATOM   2587 C CB  . ASP B 1 46  ? 20.66656  15.96379  9.94648   1.000 50.81643 ? 48  ASP B CB  1 
ATOM   2588 C CG  . ASP B 1 46  ? 20.57774  17.23578  10.74005  1.000 53.97269 ? 48  ASP B CG  1 
ATOM   2589 O OD1 . ASP B 1 46  ? 21.49434  17.49466  11.54769  1.000 53.74433 ? 48  ASP B OD1 1 
ATOM   2590 O OD2 . ASP B 1 46  ? 19.57934  17.97234  10.55661  1.000 48.84040 ? 48  ASP B OD2 1 
ATOM   2591 N N   . MET B 1 47  ? 21.86997  14.49409  7.29823   1.000 52.19765 ? 49  MET B N   1 
ATOM   2592 C CA  . MET B 1 47  ? 21.50621  13.33586  6.48790   1.000 52.04591 ? 49  MET B CA  1 
ATOM   2593 C C   . MET B 1 47  ? 22.58174  12.25966  6.47355   1.000 54.40914 ? 49  MET B C   1 
ATOM   2594 O O   . MET B 1 47  ? 22.28331  11.11656  6.11368   1.000 48.89577 ? 49  MET B O   1 
ATOM   2595 C CB  . MET B 1 47  ? 21.19081  13.77329  5.05341   1.000 54.65041 ? 49  MET B CB  1 
ATOM   2596 N N   . LEU B 1 48  ? 23.81452  12.58319  6.87193   1.000 51.50050 ? 50  LEU B N   1 
ATOM   2597 C CA  . LEU B 1 48  ? 24.88895  11.59761  6.79858   1.000 51.87467 ? 50  LEU B CA  1 
ATOM   2598 C C   . LEU B 1 48  ? 24.87517  10.64270  7.98777   1.000 50.16768 ? 50  LEU B C   1 
ATOM   2599 O O   . LEU B 1 48  ? 25.17293  9.45242   7.83290   1.000 55.68280 ? 50  LEU B O   1 
ATOM   2600 C CB  . LEU B 1 48  ? 26.24053  12.30602  6.69206   1.000 55.45671 ? 50  LEU B CB  1 
ATOM   2601 C CG  . LEU B 1 48  ? 26.51869  12.90574  5.31042   1.000 57.86341 ? 50  LEU B CG  1 
ATOM   2602 C CD1 . LEU B 1 48  ? 27.70606  13.86571  5.35622   1.000 60.39696 ? 50  LEU B CD1 1 
ATOM   2603 C CD2 . LEU B 1 48  ? 26.74408  11.80057  4.28125   1.000 51.81034 ? 50  LEU B CD2 1 
ATOM   2604 N N   . ASN B 1 49  ? 24.53852  11.13413  9.17719   1.000 44.88391 ? 51  ASN B N   1 
ATOM   2605 C CA  . ASN B 1 49  ? 24.46189  10.30185  10.37774  1.000 47.95189 ? 51  ASN B CA  1 
ATOM   2606 C C   . ASN B 1 49  ? 23.31598  10.79884  11.24841  1.000 51.70347 ? 51  ASN B C   1 
ATOM   2607 O O   . ASN B 1 49  ? 23.52746  11.34390  12.33932  1.000 49.00327 ? 51  ASN B O   1 
ATOM   2608 C CB  . ASN B 1 49  ? 25.79120  10.31721  11.13661  1.000 57.09723 ? 51  ASN B CB  1 
ATOM   2609 C CG  . ASN B 1 49  ? 25.79910  9.36362   12.31932  1.000 58.55961 ? 51  ASN B CG  1 
ATOM   2610 O OD1 . ASN B 1 49  ? 25.32900  8.22915   12.21638  1.000 60.57275 ? 51  ASN B OD1 1 
ATOM   2611 N ND2 . ASN B 1 49  ? 26.33319  9.82111   13.45355  1.000 62.00953 ? 51  ASN B ND2 1 
ATOM   2612 N N   . PRO B 1 50  ? 22.07277  10.61056  10.79762  1.000 47.64026 ? 52  PRO B N   1 
ATOM   2613 C CA  . PRO B 1 50  ? 20.93429  11.15897  11.54460  1.000 42.00450 ? 52  PRO B CA  1 
ATOM   2614 C C   . PRO B 1 50  ? 20.69244  10.41367  12.84512  1.000 42.43887 ? 52  PRO B C   1 
ATOM   2615 O O   . PRO B 1 50  ? 20.76524  9.18346   12.90723  1.000 42.05918 ? 52  PRO B O   1 
ATOM   2616 C CB  . PRO B 1 50  ? 19.74658  10.98778  10.58436  1.000 42.71970 ? 52  PRO B CB  1 
ATOM   2617 C CG  . PRO B 1 50  ? 20.29496  10.42215  9.31210   1.000 45.84224 ? 52  PRO B CG  1 
ATOM   2618 C CD  . PRO B 1 50  ? 21.64745  9.85044   9.61411   1.000 48.29956 ? 52  PRO B CD  1 
ATOM   2619 N N   . ASN B 1 51  ? 20.40058  11.18105  13.89065  1.000 40.72056 ? 53  ASN B N   1 
ATOM   2620 C CA  . ASN B 1 51  ? 19.83426  10.66478  15.13029  1.000 41.31729 ? 53  ASN B CA  1 
ATOM   2621 C C   . ASN B 1 51  ? 18.39565  11.16183  15.14881  1.000 43.26486 ? 53  ASN B C   1 
ATOM   2622 O O   . ASN B 1 51  ? 18.11315  12.26510  15.62752  1.000 41.32677 ? 53  ASN B O   1 
ATOM   2623 C CB  . ASN B 1 51  ? 20.62470  11.13520  16.35080  1.000 41.86487 ? 53  ASN B CB  1 
ATOM   2624 C CG  . ASN B 1 51  ? 20.06315  10.60305  17.65924  1.000 43.71829 ? 53  ASN B CG  1 
ATOM   2625 O OD1 . ASN B 1 51  ? 18.85106  10.40775  17.81540  1.000 46.72051 ? 53  ASN B OD1 1 
ATOM   2626 N ND2 . ASN B 1 51  ? 20.94881  10.37226  18.61730  1.000 49.23141 ? 53  ASN B ND2 1 
ATOM   2627 N N   . TYR B 1 52  ? 17.48167  10.33425  14.64307  1.000 38.56333 ? 54  TYR B N   1 
ATOM   2628 C CA  . TYR B 1 52  ? 16.15164  10.84035  14.34497  1.000 37.59901 ? 54  TYR B CA  1 
ATOM   2629 C C   . TYR B 1 52  ? 15.38877  11.22117  15.61035  1.000 38.16113 ? 54  TYR B C   1 
ATOM   2630 O O   . TYR B 1 52  ? 14.71238  12.25480  15.63194  1.000 38.30606 ? 54  TYR B O   1 
ATOM   2631 C CB  . TYR B 1 52  ? 15.38918  9.81586   13.50147  1.000 36.13052 ? 54  TYR B CB  1 
ATOM   2632 C CG  . TYR B 1 52  ? 15.68739  9.98069   12.02997  1.000 29.54382 ? 54  TYR B CG  1 
ATOM   2633 C CD1 . TYR B 1 52  ? 15.16878  11.05755  11.31934  1.000 32.07553 ? 54  TYR B CD1 1 
ATOM   2634 C CD2 . TYR B 1 52  ? 16.51773  9.08965   11.35802  1.000 32.37896 ? 54  TYR B CD2 1 
ATOM   2635 C CE1 . TYR B 1 52  ? 15.43729  11.22641  9.97571   1.000 29.26126 ? 54  TYR B CE1 1 
ATOM   2636 C CE2 . TYR B 1 52  ? 16.80054  9.25330   10.00558  1.000 32.56224 ? 54  TYR B CE2 1 
ATOM   2637 C CZ  . TYR B 1 52  ? 16.25317  10.32840  9.32064   1.000 30.80365 ? 54  TYR B CZ  1 
ATOM   2638 O OH  . TYR B 1 52  ? 16.51578  10.51310  7.97199   1.000 33.67321 ? 54  TYR B OH  1 
ATOM   2639 N N   . GLU B 1 53  ? 15.49193  10.42796  16.68553  1.000 39.35085 ? 55  GLU B N   1 
ATOM   2640 C CA  . GLU B 1 53  ? 14.73762  10.79200  17.88668  1.000 49.80994 ? 55  GLU B CA  1 
ATOM   2641 C C   . GLU B 1 53  ? 15.24382  12.10233  18.47124  1.000 45.33799 ? 55  GLU B C   1 
ATOM   2642 O O   . GLU B 1 53  ? 14.45255  12.91282  18.96976  1.000 43.05991 ? 55  GLU B O   1 
ATOM   2643 C CB  . GLU B 1 53  ? 14.78829  9.69508   18.95421  1.000 51.45558 ? 55  GLU B CB  1 
ATOM   2644 C CG  . GLU B 1 53  ? 13.64148  9.84618   19.98182  1.000 51.38966 ? 55  GLU B CG  1 
ATOM   2645 C CD  . GLU B 1 53  ? 14.04811  9.54628   21.43310  1.000 58.59673 ? 55  GLU B CD  1 
ATOM   2646 O OE1 . GLU B 1 53  ? 15.26310  9.43178   21.72120  1.000 58.56483 ? 55  GLU B OE1 1 
ATOM   2647 O OE2 . GLU B 1 53  ? 13.13903  9.44002   22.29298  1.000 60.02733 ? 55  GLU B OE2 1 
ATOM   2648 N N   . ASP B 1 54  ? 16.55511  12.33747  18.39656  1.000 47.83310 ? 56  ASP B N   1 
ATOM   2649 C CA  . ASP B 1 54  ? 17.10047  13.58804  18.90942  1.000 47.76214 ? 56  ASP B CA  1 
ATOM   2650 C C   . ASP B 1 54  ? 16.73134  14.75967  18.01275  1.000 45.06706 ? 56  ASP B C   1 
ATOM   2651 O O   . ASP B 1 54  ? 16.40394  15.84433  18.50736  1.000 43.54586 ? 56  ASP B O   1 
ATOM   2652 C CB  . ASP B 1 54  ? 18.61702  13.49367  19.05186  1.000 47.28694 ? 56  ASP B CB  1 
ATOM   2653 C CG  . ASP B 1 54  ? 19.18590  14.63423  19.87652  1.000 51.33327 ? 56  ASP B CG  1 
ATOM   2654 O OD1 . ASP B 1 54  ? 19.20653  14.50928  21.11866  1.000 56.25472 ? 56  ASP B OD1 1 
ATOM   2655 O OD2 . ASP B 1 54  ? 19.57455  15.66660  19.28550  1.000 48.29655 ? 56  ASP B OD2 1 
ATOM   2656 N N   . LEU B 1 55  ? 16.78562  14.56198  16.69248  1.000 43.38052 ? 57  LEU B N   1 
ATOM   2657 C CA  . LEU B 1 55  ? 16.37594  15.61493  15.76924  1.000 42.15387 ? 57  LEU B CA  1 
ATOM   2658 C C   . LEU B 1 55  ? 14.90624  15.97828  15.95680  1.000 42.98359 ? 57  LEU B C   1 
ATOM   2659 O O   . LEU B 1 55  ? 14.54171  17.15878  15.90274  1.000 43.84242 ? 57  LEU B O   1 
ATOM   2660 C CB  . LEU B 1 55  ? 16.65095  15.18080  14.32686  1.000 41.75247 ? 57  LEU B CB  1 
ATOM   2661 C CG  . LEU B 1 55  ? 18.13021  15.18239  13.94472  1.000 45.65672 ? 57  LEU B CG  1 
ATOM   2662 C CD1 . LEU B 1 55  ? 18.35273  14.63723  12.52039  1.000 43.86152 ? 57  LEU B CD1 1 
ATOM   2663 C CD2 . LEU B 1 55  ? 18.70656  16.58450  14.08960  1.000 44.62265 ? 57  LEU B CD2 1 
ATOM   2664 N N   . LEU B 1 56  ? 14.04188  14.98144  16.17865  1.000 41.27453 ? 58  LEU B N   1 
ATOM   2665 C CA  . LEU B 1 56  ? 12.63390  15.28955  16.41701  1.000 41.60107 ? 58  LEU B CA  1 
ATOM   2666 C C   . LEU B 1 56  ? 12.45114  15.98972  17.75666  1.000 42.13145 ? 58  LEU B C   1 
ATOM   2667 O O   . LEU B 1 56  ? 11.59818  16.87501  17.89013  1.000 41.75645 ? 58  LEU B O   1 
ATOM   2668 C CB  . LEU B 1 56  ? 11.77888  14.02035  16.35820  1.000 38.66425 ? 58  LEU B CB  1 
ATOM   2669 C CG  . LEU B 1 56  ? 10.27801  14.28477  16.19545  1.000 42.74181 ? 58  LEU B CG  1 
ATOM   2670 C CD1 . LEU B 1 56  ? 10.00892  14.99787  14.87219  1.000 41.66328 ? 58  LEU B CD1 1 
ATOM   2671 C CD2 . LEU B 1 56  ? 9.45167   13.00849  16.29573  1.000 42.15164 ? 58  LEU B CD2 1 
ATOM   2672 N N   . ILE B 1 57  ? 13.25037  15.60589  18.75635  1.000 43.52914 ? 59  ILE B N   1 
ATOM   2673 C CA  . ILE B 1 57  ? 13.22971  16.28699  20.05058  1.000 46.71386 ? 59  ILE B CA  1 
ATOM   2674 C C   . ILE B 1 57  ? 13.48058  17.77933  19.86555  1.000 44.19203 ? 59  ILE B C   1 
ATOM   2675 O O   . ILE B 1 57  ? 12.74301  18.62232  20.38990  1.000 47.28688 ? 59  ILE B O   1 
ATOM   2676 C CB  . ILE B 1 57  ? 14.26235  15.65076  20.99908  1.000 48.08415 ? 59  ILE B CB  1 
ATOM   2677 C CG1 . ILE B 1 57  ? 13.65308  14.45040  21.72317  1.000 48.03830 ? 59  ILE B CG1 1 
ATOM   2678 C CG2 . ILE B 1 57  ? 14.80138  16.66624  21.98958  1.000 49.43563 ? 59  ILE B CG2 1 
ATOM   2679 C CD1 . ILE B 1 57  ? 14.68564  13.61456  22.44981  1.000 53.76824 ? 59  ILE B CD1 1 
ATOM   2680 N N   . ARG B 1 58  ? 14.50165  18.12615  19.07535  1.000 43.64909 ? 60  ARG B N   1 
ATOM   2681 C CA  . ARG B 1 58  ? 14.84431  19.52911  18.86119  1.000 48.92300 ? 60  ARG B CA  1 
ATOM   2682 C C   . ARG B 1 58  ? 13.83307  20.27288  17.99717  1.000 46.80365 ? 60  ARG B C   1 
ATOM   2683 O O   . ARG B 1 58  ? 13.93110  21.50042  17.89460  1.000 45.43297 ? 60  ARG B O   1 
ATOM   2684 C CB  . ARG B 1 58  ? 16.23382  19.66255  18.22201  1.000 43.91229 ? 60  ARG B CB  1 
ATOM   2685 C CG  . ARG B 1 58  ? 17.37119  18.99076  18.98897  1.000 49.56520 ? 60  ARG B CG  1 
ATOM   2686 C CD  . ARG B 1 58  ? 17.24211  19.15042  20.50409  1.000 48.59603 ? 60  ARG B CD  1 
ATOM   2687 N NE  . ARG B 1 58  ? 17.81876  17.99997  21.20120  1.000 52.01527 ? 60  ARG B NE  1 
ATOM   2688 C CZ  . ARG B 1 58  ? 17.96469  17.90356  22.52081  1.000 49.07495 ? 60  ARG B CZ  1 
ATOM   2689 N NH1 . ARG B 1 58  ? 17.57611  18.89219  23.31873  1.000 46.63209 ? 60  ARG B NH1 1 
ATOM   2690 N NH2 . ARG B 1 58  ? 18.49728  16.80576  23.04325  1.000 52.03726 ? 60  ARG B NH2 1 
ATOM   2691 N N   . LYS B 1 59  ? 12.88622  19.57624  17.36844  1.000 45.68380 ? 61  LYS B N   1 
ATOM   2692 C CA  . LYS B 1 59  ? 11.86539  20.22507  16.55763  1.000 42.00114 ? 61  LYS B CA  1 
ATOM   2693 C C   . LYS B 1 59  ? 10.62730  20.49671  17.39565  1.000 39.94661 ? 61  LYS B C   1 
ATOM   2694 O O   . LYS B 1 59  ? 10.36333  19.80912  18.38232  1.000 40.74065 ? 61  LYS B O   1 
ATOM   2695 C CB  . LYS B 1 59  ? 11.48252  19.36063  15.35114  1.000 44.66527 ? 61  LYS B CB  1 
ATOM   2696 C CG  . LYS B 1 59  ? 12.53126  19.32155  14.24982  1.000 43.76073 ? 61  LYS B CG  1 
ATOM   2697 C CD  . LYS B 1 59  ? 12.72064  20.69837  13.63366  1.000 45.94688 ? 61  LYS B CD  1 
ATOM   2698 C CE  . LYS B 1 59  ? 13.70922  20.67246  12.47642  1.000 45.08252 ? 61  LYS B CE  1 
ATOM   2699 N NZ  . LYS B 1 59  ? 15.13585  20.86136  12.91655  1.000 48.90143 ? 61  LYS B NZ  1 
ATOM   2700 N N   . SER B 1 60  ? 9.87165   21.51256  16.99342  1.000 37.52952 ? 62  SER B N   1 
ATOM   2701 C CA  . SER B 1 60  ? 8.58165   21.83467  17.58539  1.000 39.51144 ? 62  SER B CA  1 
ATOM   2702 C C   . SER B 1 60  ? 7.51303   21.80790  16.49856  1.000 40.59656 ? 62  SER B C   1 
ATOM   2703 O O   . SER B 1 60  ? 7.81772   21.75681  15.30174  1.000 37.97151 ? 62  SER B O   1 
ATOM   2704 C CB  . SER B 1 60  ? 8.60570   23.21195  18.26520  1.000 42.82493 ? 62  SER B CB  1 
ATOM   2705 O OG  . SER B 1 60  ? 9.70865   23.33970  19.14833  1.000 46.54984 ? 62  SER B OG  1 
ATOM   2706 N N   . ASN B 1 61  ? 6.24543   21.85347  16.92873  1.000 38.34874 ? 63  ASN B N   1 
ATOM   2707 C CA  . ASN B 1 61  ? 5.14446   21.92413  15.97440  1.000 42.01610 ? 63  ASN B CA  1 
ATOM   2708 C C   . ASN B 1 61  ? 5.34489   23.06842  14.98435  1.000 42.99768 ? 63  ASN B C   1 
ATOM   2709 O O   . ASN B 1 61  ? 5.07798   22.91741  13.78526  1.000 39.07838 ? 63  ASN B O   1 
ATOM   2710 C CB  . ASN B 1 61  ? 3.80800   22.09034  16.70750  1.000 40.06935 ? 63  ASN B CB  1 
ATOM   2711 C CG  . ASN B 1 61  ? 3.40899   20.85813  17.50856  1.000 42.12138 ? 63  ASN B CG  1 
ATOM   2712 O OD1 . ASN B 1 61  ? 3.85768   19.73888  17.23964  1.000 41.70204 ? 63  ASN B OD1 1 
ATOM   2713 N ND2 . ASN B 1 61  ? 2.55877   21.06358  18.50788  1.000 40.13443 ? 63  ASN B ND2 1 
ATOM   2714 N N   . HIS B 1 62  ? 5.84087   24.21664  15.46437  1.000 41.05165 ? 64  HIS B N   1 
ATOM   2715 C CA  . HIS B 1 62  ? 6.02363   25.37721  14.60045  1.000 39.65935 ? 64  HIS B CA  1 
ATOM   2716 C C   . HIS B 1 62  ? 7.08760   25.15741  13.53056  1.000 43.74521 ? 64  HIS B C   1 
ATOM   2717 O O   . HIS B 1 62  ? 7.20261   25.98062  12.61387  1.000 45.00898 ? 64  HIS B O   1 
ATOM   2718 C CB  . HIS B 1 62  ? 6.35189   26.62631  15.43834  1.000 44.14262 ? 64  HIS B CB  1 
ATOM   2719 C CG  . HIS B 1 62  ? 7.64208   26.54184  16.20235  1.000 41.48848 ? 64  HIS B CG  1 
ATOM   2720 N ND1 . HIS B 1 62  ? 8.87558   26.48269  15.58553  1.000 44.24324 ? 64  HIS B ND1 1 
ATOM   2721 C CD2 . HIS B 1 62  ? 7.88928   26.53314  17.53552  1.000 40.37951 ? 64  HIS B CD2 1 
ATOM   2722 C CE1 . HIS B 1 62  ? 9.82592   26.42363  16.50465  1.000 38.50006 ? 64  HIS B CE1 1 
ATOM   2723 N NE2 . HIS B 1 62  ? 9.25483   26.45882  17.69606  1.000 42.31685 ? 64  HIS B NE2 1 
ATOM   2724 N N   . ASN B 1 63  ? 7.85941   24.07569  13.60579  1.000 40.11643 ? 65  ASN B N   1 
ATOM   2725 C CA  . ASN B 1 63  ? 8.80448   23.79575  12.53727  1.000 39.34755 ? 65  ASN B CA  1 
ATOM   2726 C C   . ASN B 1 63  ? 8.13367   23.18384  11.30956  1.000 42.23025 ? 65  ASN B C   1 
ATOM   2727 O O   . ASN B 1 63  ? 8.76623   23.12812  10.24994  1.000 41.79479 ? 65  ASN B O   1 
ATOM   2728 C CB  . ASN B 1 63  ? 9.91312   22.86282  13.03697  1.000 39.34829 ? 65  ASN B CB  1 
ATOM   2729 C CG  . ASN B 1 63  ? 10.85554  23.53566  14.04242  1.000 46.06595 ? 65  ASN B CG  1 
ATOM   2730 O OD1 . ASN B 1 63  ? 10.74280  23.32882  15.25365  1.000 43.59006 ? 65  ASN B OD1 1 
ATOM   2731 N ND2 . ASN B 1 63  ? 11.79674  24.33338  13.53507  1.000 41.89300 ? 65  ASN B ND2 1 
ATOM   2732 N N   . PHE B 1 64  ? 6.87626   22.74738  11.41920  1.000 37.45320 ? 66  PHE B N   1 
ATOM   2733 C CA  . PHE B 1 64  ? 6.19534   22.00034  10.36286  1.000 39.30869 ? 66  PHE B CA  1 
ATOM   2734 C C   . PHE B 1 64  ? 5.09421   22.84756  9.74285   1.000 41.11215 ? 66  PHE B C   1 
ATOM   2735 O O   . PHE B 1 64  ? 4.14797   23.24311  10.43222  1.000 43.53373 ? 66  PHE B O   1 
ATOM   2736 C CB  . PHE B 1 64  ? 5.60689   20.69684  10.90715  1.000 36.45561 ? 66  PHE B CB  1 
ATOM   2737 C CG  . PHE B 1 64  ? 6.63457   19.77886  11.47061  1.000 35.91512 ? 66  PHE B CG  1 
ATOM   2738 C CD1 . PHE B 1 64  ? 7.49680   19.09206  10.62776  1.000 35.89181 ? 66  PHE B CD1 1 
ATOM   2739 C CD2 . PHE B 1 64  ? 6.76361   19.62312  12.84330  1.000 34.64980 ? 66  PHE B CD2 1 
ATOM   2740 C CE1 . PHE B 1 64  ? 8.46516   18.25035  11.14727  1.000 34.85177 ? 66  PHE B CE1 1 
ATOM   2741 C CE2 . PHE B 1 64  ? 7.72520   18.78826  13.37240  1.000 37.78742 ? 66  PHE B CE2 1 
ATOM   2742 C CZ  . PHE B 1 64  ? 8.58341   18.10145  12.52127  1.000 33.74763 ? 66  PHE B CZ  1 
ATOM   2743 N N   . LEU B 1 65  ? 5.20994   23.10197  8.44156   1.000 40.75061 ? 67  LEU B N   1 
ATOM   2744 C CA  . LEU B 1 65  ? 4.18315   23.78949  7.66990   1.000 37.32366 ? 67  LEU B CA  1 
ATOM   2745 C C   . LEU B 1 65  ? 3.44778   22.76659  6.80398   1.000 39.95102 ? 67  LEU B C   1 
ATOM   2746 O O   . LEU B 1 65  ? 4.05103   22.13437  5.92833   1.000 39.86450 ? 67  LEU B O   1 
ATOM   2747 C CB  . LEU B 1 65  ? 4.80741   24.89665  6.81843   1.000 39.91616 ? 67  LEU B CB  1 
ATOM   2748 C CG  . LEU B 1 65  ? 3.84228   25.77358  6.01128   1.000 47.35676 ? 67  LEU B CG  1 
ATOM   2749 C CD1 . LEU B 1 65  ? 2.81583   26.45786  6.91312   1.000 47.43190 ? 67  LEU B CD1 1 
ATOM   2750 C CD2 . LEU B 1 65  ? 4.61677   26.80423  5.19835   1.000 48.53743 ? 67  LEU B CD2 1 
ATOM   2751 N N   . VAL B 1 66  ? 2.15282   22.59555  7.05544   1.000 39.33654 ? 68  VAL B N   1 
ATOM   2752 C CA  . VAL B 1 66  ? 1.31987   21.65809  6.31342   1.000 37.70746 ? 68  VAL B CA  1 
ATOM   2753 C C   . VAL B 1 66  ? 0.24716   22.45040  5.58134   1.000 40.61432 ? 68  VAL B C   1 
ATOM   2754 O O   . VAL B 1 66  ? -0.49675  23.21605  6.20539   1.000 41.75862 ? 68  VAL B O   1 
ATOM   2755 C CB  . VAL B 1 66  ? 0.67756   20.60844  7.23917   1.000 36.88484 ? 68  VAL B CB  1 
ATOM   2756 C CG1 . VAL B 1 66  ? -0.31212  19.73596  6.45851   1.000 35.92105 ? 68  VAL B CG1 1 
ATOM   2757 C CG2 . VAL B 1 66  ? 1.73919   19.75716  7.90503   1.000 35.23187 ? 68  VAL B CG2 1 
ATOM   2758 N N   . GLN B 1 67  ? 0.15310   22.24912  4.26761   1.000 42.15943 ? 69  GLN B N   1 
ATOM   2759 C CA  . GLN B 1 67  ? -0.83851  22.92370  3.43800   1.000 42.39995 ? 69  GLN B CA  1 
ATOM   2760 C C   . GLN B 1 67  ? -1.60432  21.90046  2.60722   1.000 40.58023 ? 69  GLN B C   1 
ATOM   2761 O O   . GLN B 1 67  ? -1.00403  21.08925  1.89390   1.000 36.69332 ? 69  GLN B O   1 
ATOM   2762 C CB  . GLN B 1 67  ? -0.18007  23.97148  2.52544   1.000 42.11466 ? 69  GLN B CB  1 
ATOM   2763 C CG  . GLN B 1 67  ? 0.93943   24.78070  3.20010   1.000 49.33534 ? 69  GLN B CG  1 
ATOM   2764 C CD  . GLN B 1 67  ? 1.71477   25.64564  2.21670   1.000 55.62481 ? 69  GLN B CD  1 
ATOM   2765 O OE1 . GLN B 1 67  ? 1.13425   26.25154  1.31127   1.000 59.84559 ? 69  GLN B OE1 1 
ATOM   2766 N NE2 . GLN B 1 67  ? 3.03093   25.70505  2.38873   1.000 50.47232 ? 69  GLN B NE2 1 
ATOM   2767 N N   . ALA B 1 68  ? -2.92484  21.94036  2.71191   1.000 41.26751 ? 70  ALA B N   1 
ATOM   2768 C CA  . ALA B 1 68  ? -3.83294  21.11659  1.91990   1.000 43.18344 ? 70  ALA B CA  1 
ATOM   2769 C C   . ALA B 1 68  ? -4.47373  22.05125  0.89916   1.000 43.86988 ? 70  ALA B C   1 
ATOM   2770 O O   . ALA B 1 68  ? -5.48688  22.69035  1.17934   1.000 48.59924 ? 70  ALA B O   1 
ATOM   2771 C CB  . ALA B 1 68  ? -4.88091  20.44049  2.80317   1.000 39.71508 ? 70  ALA B CB  1 
ATOM   2772 N N   . GLY B 1 69  ? -3.86309  22.13793  -0.28169  1.000 46.31777 ? 71  GLY B N   1 
ATOM   2773 C CA  . GLY B 1 69  ? -4.27456  23.10769  -1.27742  1.000 49.92392 ? 71  GLY B CA  1 
ATOM   2774 C C   . GLY B 1 69  ? -4.05058  24.53030  -0.80640  1.000 53.38304 ? 71  GLY B C   1 
ATOM   2775 O O   . GLY B 1 69  ? -2.90601  24.96163  -0.62940  1.000 52.77362 ? 71  GLY B O   1 
ATOM   2776 N N   . ASN B 1 70  ? -5.13987  25.26560  -0.57960  1.000 55.78606 ? 72  ASN B N   1 
ATOM   2777 C CA  . ASN B 1 70  ? -5.01709  26.63459  -0.09053  1.000 57.96756 ? 72  ASN B CA  1 
ATOM   2778 C C   . ASN B 1 70  ? -4.86291  26.69166  1.42781   1.000 58.28889 ? 72  ASN B C   1 
ATOM   2779 O O   . ASN B 1 70  ? -4.17236  27.57879  1.94080   1.000 61.55832 ? 72  ASN B O   1 
ATOM   2780 C CB  . ASN B 1 70  ? -6.23074  27.46096  -0.53438  1.000 56.36188 ? 72  ASN B CB  1 
ATOM   2781 N N   . VAL B 1 71  ? -5.45818  25.74824  2.15185   1.000 52.89438 ? 73  VAL B N   1 
ATOM   2782 C CA  . VAL B 1 71  ? -5.55251  25.82802  3.60798   1.000 51.49567 ? 73  VAL B CA  1 
ATOM   2783 C C   . VAL B 1 71  ? -4.25299  25.35980  4.25514   1.000 52.41863 ? 73  VAL B C   1 
ATOM   2784 O O   . VAL B 1 71  ? -3.70390  24.31055  3.89467   1.000 46.55957 ? 73  VAL B O   1 
ATOM   2785 C CB  . VAL B 1 71  ? -6.73629  24.99279  4.11395   1.000 48.85168 ? 73  VAL B CB  1 
ATOM   2786 C CG1 . VAL B 1 71  ? -6.87110  25.14305  5.60744   1.000 53.13445 ? 73  VAL B CG1 1 
ATOM   2787 C CG2 . VAL B 1 71  ? -8.02054  25.40161  3.40215   1.000 49.22060 ? 73  VAL B CG2 1 
ATOM   2788 N N   . GLN B 1 72  ? -3.76946  26.12936  5.23170   1.000 48.63570 ? 74  GLN B N   1 
ATOM   2789 C CA  . GLN B 1 72  ? -2.70944  25.66239  6.11272   1.000 48.39652 ? 74  GLN B CA  1 
ATOM   2790 C C   . GLN B 1 72  ? -3.33051  24.85583  7.24421   1.000 46.31123 ? 74  GLN B C   1 
ATOM   2791 O O   . GLN B 1 72  ? -4.32044  25.27957  7.84959   1.000 50.45153 ? 74  GLN B O   1 
ATOM   2792 C CB  . GLN B 1 72  ? -1.90469  26.83693  6.66934   1.000 47.49866 ? 74  GLN B CB  1 
ATOM   2793 N N   . LEU B 1 73  ? -2.78094  23.67365  7.50175   1.000 46.52007 ? 75  LEU B N   1 
ATOM   2794 C CA  . LEU B 1 73  ? -3.22884  22.83532  8.60720   1.000 41.11598 ? 75  LEU B CA  1 
ATOM   2795 C C   . LEU B 1 73  ? -2.27796  23.02901  9.77618   1.000 42.74132 ? 75  LEU B C   1 
ATOM   2796 O O   . LEU B 1 73  ? -1.06149  22.85354  9.63209   1.000 43.97955 ? 75  LEU B O   1 
ATOM   2797 C CB  . LEU B 1 73  ? -3.28492  21.35638  8.21795   1.000 41.41045 ? 75  LEU B CB  1 
ATOM   2798 C CG  . LEU B 1 73  ? -4.11988  20.94772  7.00377   1.000 41.91736 ? 75  LEU B CG  1 
ATOM   2799 C CD1 . LEU B 1 73  ? -4.15055  19.43311  6.87464   1.000 36.95516 ? 75  LEU B CD1 1 
ATOM   2800 C CD2 . LEU B 1 73  ? -5.52217  21.50556  7.10844   1.000 40.29245 ? 75  LEU B CD2 1 
ATOM   2801 N N   . ARG B 1 74  ? -2.83068  23.39985  10.92254  1.000 40.43227 ? 76  ARG B N   1 
ATOM   2802 C CA  . ARG B 1 74  ? -2.01978  23.68581  12.09498  1.000 41.52285 ? 76  ARG B CA  1 
ATOM   2803 C C   . ARG B 1 74  ? -1.57948  22.37458  12.72812  1.000 38.98214 ? 76  ARG B C   1 
ATOM   2804 O O   . ARG B 1 74  ? -2.41532  21.54438  13.08579  1.000 37.89535 ? 76  ARG B O   1 
ATOM   2805 C CB  . ARG B 1 74  ? -2.80407  24.53933  13.08913  1.000 42.33975 ? 76  ARG B CB  1 
ATOM   2806 N N   . VAL B 1 75  ? -0.27039  22.18748  12.86042  1.000 39.11519 ? 77  VAL B N   1 
ATOM   2807 C CA  . VAL B 1 75  ? 0.27143   20.97762  13.46908  1.000 35.89509 ? 77  VAL B CA  1 
ATOM   2808 C C   . VAL B 1 75  ? 0.22002   21.14599  14.98113  1.000 42.60655 ? 77  VAL B C   1 
ATOM   2809 O O   . VAL B 1 75  ? 0.74457   22.12499  15.52457  1.000 40.71669 ? 77  VAL B O   1 
ATOM   2810 C CB  . VAL B 1 75  ? 1.70513   20.70895  12.98868  1.000 39.88856 ? 77  VAL B CB  1 
ATOM   2811 N N   . ILE B 1 76  ? -0.40344  20.18901  15.66588  1.000 36.94645 ? 78  ILE B N   1 
ATOM   2812 C CA  . ILE B 1 76  ? -0.57046  20.24636  17.11064  1.000 38.00624 ? 78  ILE B CA  1 
ATOM   2813 C C   . ILE B 1 76  ? 0.14730   19.11767  17.83233  1.000 39.67843 ? 78  ILE B C   1 
ATOM   2814 O O   . ILE B 1 76  ? 0.03283   19.00778  19.05613  1.000 40.62957 ? 78  ILE B O   1 
ATOM   2815 C CB  . ILE B 1 76  ? -2.06322  20.26424  17.49191  1.000 38.80720 ? 78  ILE B CB  1 
ATOM   2816 C CG1 . ILE B 1 76  ? -2.74529  18.96008  17.06225  1.000 38.23816 ? 78  ILE B CG1 1 
ATOM   2817 C CG2 . ILE B 1 76  ? -2.74936  21.45660  16.83605  1.000 40.28716 ? 78  ILE B CG2 1 
ATOM   2818 C CD1 . ILE B 1 76  ? -4.20339  18.86609  17.48161  1.000 36.97651 ? 78  ILE B CD1 1 
ATOM   2819 N N   . GLY B 1 77  ? 0.88677   18.28256  17.11649  1.000 41.78586 ? 79  GLY B N   1 
ATOM   2820 C CA  . GLY B 1 77  ? 1.66542   17.23272  17.74027  1.000 37.14199 ? 79  GLY B CA  1 
ATOM   2821 C C   . GLY B 1 77  ? 2.50028   16.53858  16.69000  1.000 37.42057 ? 79  GLY B C   1 
ATOM   2822 O O   . GLY B 1 77  ? 2.19699   16.59288  15.49505  1.000 36.04281 ? 79  GLY B O   1 
ATOM   2823 N N   . HIS B 1 78  ? 3.57617   15.91210  17.14786  1.000 33.90667 ? 80  HIS B N   1 
ATOM   2824 C CA  . HIS B 1 78  ? 4.45015   15.22839  16.21178  1.000 34.44206 ? 80  HIS B CA  1 
ATOM   2825 C C   . HIS B 1 78  ? 5.06959   14.02550  16.89984  1.000 37.89769 ? 80  HIS B C   1 
ATOM   2826 O O   . HIS B 1 78  ? 5.44198   14.08193  18.07524  1.000 37.34159 ? 80  HIS B O   1 
ATOM   2827 C CB  . HIS B 1 78  ? 5.53453   16.16015  15.65259  1.000 33.41246 ? 80  HIS B CB  1 
ATOM   2828 C CG  . HIS B 1 78  ? 6.32059   16.88610  16.70023  1.000 37.82501 ? 80  HIS B CG  1 
ATOM   2829 N ND1 . HIS B 1 78  ? 5.85155   18.01844  17.33321  1.000 40.57852 ? 80  HIS B ND1 1 
ATOM   2830 C CD2 . HIS B 1 78  ? 7.55070   16.65004  17.21555  1.000 41.43376 ? 80  HIS B CD2 1 
ATOM   2831 C CE1 . HIS B 1 78  ? 6.75465   18.44155  18.20047  1.000 42.71625 ? 80  HIS B CE1 1 
ATOM   2832 N NE2 . HIS B 1 78  ? 7.79569   17.63064  18.14710  1.000 40.46403 ? 80  HIS B NE2 1 
ATOM   2833 N N   . SER B 1 79  ? 5.14914   12.93049  16.16017  1.000 31.86354 ? 81  SER B N   1 
ATOM   2834 C CA  . SER B 1 79  ? 5.74167   11.71206  16.67070  1.000 35.10572 ? 81  SER B CA  1 
ATOM   2835 C C   . SER B 1 79  ? 6.27210   10.92637  15.48677  1.000 36.04770 ? 81  SER B C   1 
ATOM   2836 O O   . SER B 1 79  ? 6.09961   11.30993  14.32777  1.000 33.33192 ? 81  SER B O   1 
ATOM   2837 C CB  . SER B 1 79  ? 4.74200   10.89140  17.49540  1.000 35.29530 ? 81  SER B CB  1 
ATOM   2838 O OG  . SER B 1 79  ? 3.59424   10.54056  16.74444  1.000 40.25353 ? 81  SER B OG  1 
ATOM   2839 N N   . MET B 1 80  ? 6.93092   9.82373   15.79736  1.000 36.27326 ? 82  MET B N   1 
ATOM   2840 C CA  . MET B 1 80  ? 7.56112   8.98090   14.80249  1.000 36.18463 ? 82  MET B CA  1 
ATOM   2841 C C   . MET B 1 80  ? 7.09194   7.55392   14.99361  1.000 31.94801 ? 82  MET B C   1 
ATOM   2842 O O   . MET B 1 80  ? 6.99502   7.07748   16.12429  1.000 32.04716 ? 82  MET B O   1 
ATOM   2843 C CB  . MET B 1 80  ? 9.07254   9.03269   14.94113  1.000 37.79774 ? 82  MET B CB  1 
ATOM   2844 C CG  . MET B 1 80  ? 9.80540   9.18509   13.66478  1.000 35.14705 ? 82  MET B CG  1 
ATOM   2845 S SD  . MET B 1 80  ? 11.56178  9.35043   14.02208  1.000 40.65267 ? 82  MET B SD  1 
ATOM   2846 C CE  . MET B 1 80  ? 11.56699  10.24952  15.57928  1.000 43.61596 ? 82  MET B CE  1 
ATOM   2847 N N   . GLN B 1 81  ? 6.80414   6.87244   13.89054  1.000 30.38705 ? 83  GLN B N   1 
ATOM   2848 C CA  . GLN B 1 81  ? 6.69753   5.42044   13.89647  1.000 28.30546 ? 83  GLN B CA  1 
ATOM   2849 C C   . GLN B 1 81  ? 7.64905   4.88978   12.84130  1.000 26.88871 ? 83  GLN B C   1 
ATOM   2850 O O   . GLN B 1 81  ? 7.40582   5.05297   11.64105  1.000 25.02839 ? 83  GLN B O   1 
ATOM   2851 C CB  . GLN B 1 81  ? 5.27667   4.93074   13.63584  1.000 29.41515 ? 83  GLN B CB  1 
ATOM   2852 C CG  . GLN B 1 81  ? 5.18645   3.41199   13.72672  1.000 32.27239 ? 83  GLN B CG  1 
ATOM   2853 C CD  . GLN B 1 81  ? 3.82032   2.87797   13.35610  1.000 37.50183 ? 83  GLN B CD  1 
ATOM   2854 O OE1 . GLN B 1 81  ? 2.96140   3.61799   12.87075  1.000 37.29571 ? 83  GLN B OE1 1 
ATOM   2855 N NE2 . GLN B 1 81  ? 3.60700   1.58788   13.59148  1.000 39.17912 ? 83  GLN B NE2 1 
ATOM   2856 N N   . ASN B 1 82  ? 8.71795   4.24164   13.29109  1.000 26.13863 ? 84  ASN B N   1 
ATOM   2857 C CA  . ASN B 1 82  ? 9.74789   3.70076   12.39802  1.000 26.77340 ? 84  ASN B CA  1 
ATOM   2858 C C   . ASN B 1 82  ? 10.19424  4.85670   11.50277  1.000 26.60242 ? 84  ASN B C   1 
ATOM   2859 O O   . ASN B 1 82  ? 10.53893  5.92147   12.03411  1.000 27.37258 ? 84  ASN B O   1 
ATOM   2860 C CB  . ASN B 1 82  ? 9.21320   2.45496   11.67984  1.000 22.21276 ? 84  ASN B CB  1 
ATOM   2861 C CG  . ASN B 1 82  ? 8.84009   1.33792   12.64357  1.000 26.05374 ? 84  ASN B CG  1 
ATOM   2862 O OD1 . ASN B 1 82  ? 9.60012   1.02075   13.57186  1.000 29.71386 ? 84  ASN B OD1 1 
ATOM   2863 N ND2 . ASN B 1 82  ? 7.67029   0.73534   12.43777  1.000 24.94901 ? 84  ASN B ND2 1 
ATOM   2864 N N   . CYS B 1 83  ? 10.15120  4.72120   10.17968  1.000 23.44399 ? 85  CYS B N   1 
ATOM   2865 C CA  . CYS B 1 83  ? 10.65375  5.75046   9.28580   1.000 23.23401 ? 85  CYS B CA  1 
ATOM   2866 C C   . CYS B 1 83  ? 9.58969   6.74496   8.83951   1.000 23.69324 ? 85  CYS B C   1 
ATOM   2867 O O   . CYS B 1 83  ? 9.85168   7.54450   7.93668   1.000 23.51452 ? 85  CYS B O   1 
ATOM   2868 C CB  . CYS B 1 83  ? 11.31199  5.09898   8.07116   1.000 24.72554 ? 85  CYS B CB  1 
ATOM   2869 S SG  . CYS B 1 83  ? 12.77094  4.13010   8.58840   1.000 25.62296 ? 85  CYS B SG  1 
ATOM   2870 N N   . VAL B 1 84  ? 8.41497   6.74839   9.46269   1.000 25.58795 ? 86  VAL B N   1 
ATOM   2871 C CA  . VAL B 1 84  ? 7.33854   7.64521   9.06407   1.000 23.57207 ? 86  VAL B CA  1 
ATOM   2872 C C   . VAL B 1 84  ? 7.10725   8.66497   10.17051  1.000 28.83639 ? 86  VAL B C   1 
ATOM   2873 O O   . VAL B 1 84  ? 7.01108   8.30677   11.35364  1.000 28.67175 ? 86  VAL B O   1 
ATOM   2874 C CB  . VAL B 1 84  ? 6.05275   6.86060   8.73470   1.000 26.36932 ? 86  VAL B CB  1 
ATOM   2875 C CG1 . VAL B 1 84  ? 4.82429   7.74054   8.86415   1.000 27.67761 ? 86  VAL B CG1 1 
ATOM   2876 C CG2 . VAL B 1 84  ? 6.16444   6.29459   7.32678   1.000 24.10183 ? 86  VAL B CG2 1 
ATOM   2877 N N   . LEU B 1 85  ? 7.05138   9.93753   9.78238   1.000 26.09007 ? 87  LEU B N   1 
ATOM   2878 C CA  . LEU B 1 85  ? 6.69255   11.02971  10.67223  1.000 27.25774 ? 87  LEU B CA  1 
ATOM   2879 C C   . LEU B 1 85  ? 5.17518   11.17819  10.69815  1.000 30.60078 ? 87  LEU B C   1 
ATOM   2880 O O   . LEU B 1 85  ? 4.52801   11.16359  9.64198   1.000 30.48903 ? 87  LEU B O   1 
ATOM   2881 C CB  . LEU B 1 85  ? 7.35471   12.32433  10.19850  1.000 28.31875 ? 87  LEU B CB  1 
ATOM   2882 C CG  . LEU B 1 85  ? 6.99742   13.58678  10.96911  1.000 35.21965 ? 87  LEU B CG  1 
ATOM   2883 C CD1 . LEU B 1 85  ? 7.59543   13.54038  12.38890  1.000 35.80091 ? 87  LEU B CD1 1 
ATOM   2884 C CD2 . LEU B 1 85  ? 7.47274   14.81671  10.20239  1.000 32.56744 ? 87  LEU B CD2 1 
ATOM   2885 N N   . LYS B 1 86  ? 4.60823   11.29463  11.90123  1.000 27.95781 ? 88  LYS B N   1 
ATOM   2886 C CA  . LYS B 1 86  ? 3.16745   11.46821  12.09698  1.000 31.36653 ? 88  LYS B CA  1 
ATOM   2887 C C   . LYS B 1 86  ? 2.91757   12.85186  12.68874  1.000 35.00766 ? 88  LYS B C   1 
ATOM   2888 O O   . LYS B 1 86  ? 3.26364   13.11500  13.84660  1.000 34.38091 ? 88  LYS B O   1 
ATOM   2889 C CB  . LYS B 1 86  ? 2.59326   10.38294  13.00378  1.000 28.11673 ? 88  LYS B CB  1 
ATOM   2890 C CG  . LYS B 1 86  ? 2.58837   8.99607   12.39614  1.000 33.33618 ? 88  LYS B CG  1 
ATOM   2891 C CD  . LYS B 1 86  ? 2.43094   7.94349   13.47812  1.000 37.17876 ? 88  LYS B CD  1 
ATOM   2892 C CE  . LYS B 1 86  ? 1.02179   7.90268   13.99677  1.000 42.17927 ? 88  LYS B CE  1 
ATOM   2893 N NZ  . LYS B 1 86  ? 0.90097   7.06012   15.22251  1.000 45.28339 ? 88  LYS B NZ  1 
ATOM   2894 N N   . LEU B 1 87  ? 2.33339   13.73560  11.89545  1.000 29.82558 ? 89  LEU B N   1 
ATOM   2895 C CA  . LEU B 1 87  ? 2.00901   15.07779  12.33930  1.000 29.35560 ? 89  LEU B CA  1 
ATOM   2896 C C   . LEU B 1 87  ? 0.52546   15.10404  12.65452  1.000 32.51460 ? 89  LEU B C   1 
ATOM   2897 O O   . LEU B 1 87  ? -0.30621  14.97562  11.75193  1.000 32.61781 ? 89  LEU B O   1 
ATOM   2898 C CB  . LEU B 1 87  ? 2.35500   16.11067  11.27404  1.000 30.28736 ? 89  LEU B CB  1 
ATOM   2899 C CG  . LEU B 1 87  ? 3.81245   16.11594  10.83244  1.000 31.06160 ? 89  LEU B CG  1 
ATOM   2900 C CD1 . LEU B 1 87  ? 4.01706   17.12402  9.73324   1.000 33.02948 ? 89  LEU B CD1 1 
ATOM   2901 C CD2 . LEU B 1 87  ? 4.70835   16.42012  12.02883  1.000 30.64998 ? 89  LEU B CD2 1 
ATOM   2902 N N   . LYS B 1 88  ? 0.19234   15.24836  13.92775  1.000 33.06929 ? 90  LYS B N   1 
ATOM   2903 C CA  . LYS B 1 88  ? -1.19705  15.47292  14.30325  1.000 33.36070 ? 90  LYS B CA  1 
ATOM   2904 C C   . LYS B 1 88  ? -1.56180  16.91113  13.96717  1.000 35.22459 ? 90  LYS B C   1 
ATOM   2905 O O   . LYS B 1 88  ? -0.76719  17.83164  14.18220  1.000 37.30949 ? 90  LYS B O   1 
ATOM   2906 C CB  . LYS B 1 88  ? -1.40469  15.18881  15.78981  1.000 40.16785 ? 90  LYS B CB  1 
ATOM   2907 C CG  . LYS B 1 88  ? -2.86837  15.12025  16.21685  1.000 39.18213 ? 90  LYS B CG  1 
ATOM   2908 C CD  . LYS B 1 88  ? -2.98445  14.57520  17.62349  1.000 45.67029 ? 90  LYS B CD  1 
ATOM   2909 C CE  . LYS B 1 88  ? -4.42288  14.61225  18.11496  1.000 46.53159 ? 90  LYS B CE  1 
ATOM   2910 N NZ  . LYS B 1 88  ? -4.63698  13.68772  19.27010  1.000 59.89565 ? 90  LYS B NZ  1 
ATOM   2911 N N   . VAL B 1 89  ? -2.74306  17.10505  13.38722  1.000 36.67273 ? 91  VAL B N   1 
ATOM   2912 C CA  . VAL B 1 89  ? -3.12405  18.41110  12.87300  1.000 36.68955 ? 91  VAL B CA  1 
ATOM   2913 C C   . VAL B 1 89  ? -4.47028  18.82551  13.46407  1.000 39.13759 ? 91  VAL B C   1 
ATOM   2914 O O   . VAL B 1 89  ? -5.19149  18.02627  14.06640  1.000 38.42326 ? 91  VAL B O   1 
ATOM   2915 C CB  . VAL B 1 89  ? -3.16335  18.45032  11.33077  1.000 35.62676 ? 91  VAL B CB  1 
ATOM   2916 C CG1 . VAL B 1 89  ? -1.75035  18.36319  10.76647  1.000 34.92090 ? 91  VAL B CG1 1 
ATOM   2917 C CG2 . VAL B 1 89  ? -4.07166  17.33851  10.77838  1.000 33.71156 ? 91  VAL B CG2 1 
ATOM   2918 N N   . ASP B 1 90  ? -4.78102  20.11555  13.26985  1.000 43.18075 ? 92  ASP B N   1 
ATOM   2919 C CA  . ASP B 1 90  ? -6.00326  20.75102  13.77282  1.000 49.09070 ? 92  ASP B CA  1 
ATOM   2920 C C   . ASP B 1 90  ? -7.26928  19.99538  13.41269  1.000 48.19202 ? 92  ASP B C   1 
ATOM   2921 O O   . ASP B 1 90  ? -8.21088  19.92028  14.21190  1.000 45.91095 ? 92  ASP B O   1 
ATOM   2922 C CB  . ASP B 1 90  ? -6.12486  22.15983  13.18420  1.000 51.15636 ? 92  ASP B CB  1 
ATOM   2923 C CG  . ASP B 1 90  ? -5.93112  23.23574  14.20372  1.000 53.21501 ? 92  ASP B CG  1 
ATOM   2924 O OD1 . ASP B 1 90  ? -6.03980  22.92972  15.40837  1.000 60.02835 ? 92  ASP B OD1 1 
ATOM   2925 O OD2 . ASP B 1 90  ? -5.70275  24.39555  13.79924  1.000 57.96451 ? 92  ASP B OD2 1 
ATOM   2926 N N   . THR B 1 91  ? -7.34475  19.50617  12.18793  1.000 47.22016 ? 93  THR B N   1 
ATOM   2927 C CA  . THR B 1 91  ? -8.61838  19.18714  11.57142  1.000 43.58661 ? 93  THR B CA  1 
ATOM   2928 C C   . THR B 1 91  ? -8.56440  17.79943  10.96428  1.000 44.19147 ? 93  THR B C   1 
ATOM   2929 O O   . THR B 1 91  ? -7.56732  17.42085  10.33760  1.000 41.00568 ? 93  THR B O   1 
ATOM   2930 C CB  . THR B 1 91  ? -8.96491  20.20088  10.48096  1.000 46.75034 ? 93  THR B CB  1 
ATOM   2931 O OG1 . THR B 1 91  ? -8.47865  21.49606  10.85725  1.000 50.36410 ? 93  THR B OG1 1 
ATOM   2932 C CG2 . THR B 1 91  ? -10.47727 20.26373  10.27521  1.000 48.86280 ? 93  THR B CG2 1 
ATOM   2933 N N   . ALA B 1 92  ? -9.64324  17.05322  11.14883  1.000 36.80704 ? 94  ALA B N   1 
ATOM   2934 C CA  . ALA B 1 92  ? -9.77713  15.76764  10.48791  1.000 40.59276 ? 94  ALA B CA  1 
ATOM   2935 C C   . ALA B 1 92  ? -10.07331 15.97709  9.00737   1.000 40.51534 ? 94  ALA B C   1 
ATOM   2936 O O   . ALA B 1 92  ? -10.85593 16.85774  8.63495   1.000 38.09952 ? 94  ALA B O   1 
ATOM   2937 C CB  . ALA B 1 92  ? -10.88568 14.95020  11.15003  1.000 33.65208 ? 94  ALA B CB  1 
ATOM   2938 N N   . ASN B 1 93  ? -9.43775  15.17091  8.15841   1.000 35.92650 ? 95  ASN B N   1 
ATOM   2939 C CA  . ASN B 1 93  ? -9.65555  15.28731  6.71847   1.000 33.53255 ? 95  ASN B CA  1 
ATOM   2940 C C   . ASN B 1 93  ? -11.08233 14.87567  6.36844   1.000 30.92755 ? 95  ASN B C   1 
ATOM   2941 O O   . ASN B 1 93  ? -11.44040 13.70589  6.54827   1.000 31.85633 ? 95  ASN B O   1 
ATOM   2942 C CB  . ASN B 1 93  ? -8.65374  14.42555  5.96686   1.000 34.06227 ? 95  ASN B CB  1 
ATOM   2943 C CG  . ASN B 1 93  ? -8.77632  14.56562  4.46868   1.000 36.00074 ? 95  ASN B CG  1 
ATOM   2944 O OD1 . ASN B 1 93  ? -9.54676  15.38985  3.97058   1.000 36.52882 ? 95  ASN B OD1 1 
ATOM   2945 N ND2 . ASN B 1 93  ? -7.99884  13.77000  3.73213   1.000 31.53037 ? 95  ASN B ND2 1 
ATOM   2946 N N   . PRO B 1 94  ? -11.92595 15.78390  5.86888   1.000 34.06575 ? 96  PRO B N   1 
ATOM   2947 C CA  . PRO B 1 94  ? -13.31377 15.39671  5.57049   1.000 32.77332 ? 96  PRO B CA  1 
ATOM   2948 C C   . PRO B 1 94  ? -13.43285 14.43255  4.40720   1.000 35.51907 ? 96  PRO B C   1 
ATOM   2949 O O   . PRO B 1 94  ? -14.50953 13.84960  4.21810   1.000 35.32633 ? 96  PRO B O   1 
ATOM   2950 C CB  . PRO B 1 94  ? -13.99809 16.73637  5.25703   1.000 34.13342 ? 96  PRO B CB  1 
ATOM   2951 C CG  . PRO B 1 94  ? -12.92427 17.63320  4.81366   1.000 34.84281 ? 96  PRO B CG  1 
ATOM   2952 C CD  . PRO B 1 94  ? -11.65011 17.18852  5.51930   1.000 30.96853 ? 96  PRO B CD  1 
ATOM   2953 N N   . LYS B 1 95  ? -12.36745 14.24751  3.62562   1.000 33.01561 ? 97  LYS B N   1 
ATOM   2954 C CA  . LYS B 1 95  ? -12.35533 13.32561  2.50003   1.000 34.33522 ? 97  LYS B CA  1 
ATOM   2955 C C   . LYS B 1 95  ? -11.60714 12.02935  2.80281   1.000 36.00297 ? 97  LYS B C   1 
ATOM   2956 O O   . LYS B 1 95  ? -11.24815 11.30629  1.86550   1.000 34.63503 ? 97  LYS B O   1 
ATOM   2957 C CB  . LYS B 1 95  ? -11.73158 13.99575  1.27537   1.000 32.45246 ? 97  LYS B CB  1 
ATOM   2958 C CG  . LYS B 1 95  ? -12.47107 15.22550  0.75680   1.000 38.47232 ? 97  LYS B CG  1 
ATOM   2959 C CD  . LYS B 1 95  ? -11.45511 16.18567  0.18119   1.000 41.03641 ? 97  LYS B CD  1 
ATOM   2960 C CE  . LYS B 1 95  ? -11.99832 17.06711  -0.92165  1.000 47.16146 ? 97  LYS B CE  1 
ATOM   2961 N NZ  . LYS B 1 95  ? -10.84063 17.64937  -1.67175  1.000 51.90056 ? 97  LYS B NZ  1 
ATOM   2962 N N   . THR B 1 96  ? -11.34391 11.73259  4.07603   1.000 34.86212 ? 98  THR B N   1 
ATOM   2963 C CA  . THR B 1 96  ? -10.70866 10.46782  4.45188   1.000 31.43893 ? 98  THR B CA  1 
ATOM   2964 C C   . THR B 1 96  ? -11.56901 9.30788   3.95525   1.000 32.89402 ? 98  THR B C   1 
ATOM   2965 O O   . THR B 1 96  ? -12.73803 9.20474   4.35499   1.000 28.25212 ? 98  THR B O   1 
ATOM   2966 C CB  . THR B 1 96  ? -10.53613 10.35727  5.97646   1.000 33.58247 ? 98  THR B CB  1 
ATOM   2967 O OG1 . THR B 1 96  ? -9.83888  11.50253  6.49563   1.000 29.31910 ? 98  THR B OG1 1 
ATOM   2968 C CG2 . THR B 1 96  ? -9.77530  9.09039   6.34951   1.000 31.48896 ? 98  THR B CG2 1 
ATOM   2969 N N   . PRO B 1 97  ? -11.05806 8.42568   3.09976   1.000 31.52157 ? 99  PRO B N   1 
ATOM   2970 C CA  . PRO B 1 97  ? -11.84726 7.25818   2.68821   1.000 30.71293 ? 99  PRO B CA  1 
ATOM   2971 C C   . PRO B 1 97  ? -11.80978 6.18502   3.76985   1.000 31.46117 ? 99  PRO B C   1 
ATOM   2972 O O   . PRO B 1 97  ? -11.06417 6.28035   4.74698   1.000 30.93857 ? 99  PRO B O   1 
ATOM   2973 C CB  . PRO B 1 97  ? -11.13552 6.78601   1.41384   1.000 29.42783 ? 99  PRO B CB  1 
ATOM   2974 C CG  . PRO B 1 97  ? -9.69322  7.13909   1.67571   1.000 27.19706 ? 99  PRO B CG  1 
ATOM   2975 C CD  . PRO B 1 97  ? -9.73263  8.45422   2.44707   1.000 28.42979 ? 99  PRO B CD  1 
ATOM   2976 N N   . LYS B 1 98  ? -12.63809 5.15525   3.58685   1.000 26.76146 ? 100 LYS B N   1 
ATOM   2977 C CA  . LYS B 1 98  ? -12.37840 3.89352   4.27089   1.000 28.92172 ? 100 LYS B CA  1 
ATOM   2978 C C   . LYS B 1 98  ? -11.00614 3.39315   3.84470   1.000 27.01896 ? 100 LYS B C   1 
ATOM   2979 O O   . LYS B 1 98  ? -10.71163 3.32701   2.65021   1.000 26.23930 ? 100 LYS B O   1 
ATOM   2980 C CB  . LYS B 1 98  ? -13.43282 2.84526   3.92685   1.000 28.02424 ? 100 LYS B CB  1 
ATOM   2981 N N   . TYR B 1 99  ? -10.15954 3.05145   4.80958   1.000 26.92869 ? 101 TYR B N   1 
ATOM   2982 C CA  . TYR B 1 99  ? -8.79244  2.69821   4.44420   1.000 26.24607 ? 101 TYR B CA  1 
ATOM   2983 C C   . TYR B 1 99  ? -8.19905  1.75226   5.47719   1.000 27.62305 ? 101 TYR B C   1 
ATOM   2984 O O   . TYR B 1 99  ? -8.66858  1.65644   6.61634   1.000 25.92858 ? 101 TYR B O   1 
ATOM   2985 C CB  . TYR B 1 99  ? -7.89417  3.94707   4.30223   1.000 26.10142 ? 101 TYR B CB  1 
ATOM   2986 C CG  . TYR B 1 99  ? -7.39062  4.46069   5.63712   1.000 26.20869 ? 101 TYR B CG  1 
ATOM   2987 C CD1 . TYR B 1 99  ? -8.16648  5.33808   6.39428   1.000 26.58816 ? 101 TYR B CD1 1 
ATOM   2988 C CD2 . TYR B 1 99  ? -6.15794  4.05691   6.14987   1.000 26.44694 ? 101 TYR B CD2 1 
ATOM   2989 C CE1 . TYR B 1 99  ? -7.73022  5.80649   7.62166   1.000 28.40777 ? 101 TYR B CE1 1 
ATOM   2990 C CE2 . TYR B 1 99  ? -5.71766  4.50838   7.38534   1.000 26.03841 ? 101 TYR B CE2 1 
ATOM   2991 C CZ  . TYR B 1 99  ? -6.50601  5.39022   8.11259   1.000 28.21977 ? 101 TYR B CZ  1 
ATOM   2992 O OH  . TYR B 1 99  ? -6.07881  5.84854   9.33682   1.000 27.87749 ? 101 TYR B OH  1 
ATOM   2993 N N   . LYS B 1 100 ? -7.12621  1.07659   5.06052   1.000 24.82968 ? 102 LYS B N   1 
ATOM   2994 C CA  . LYS B 1 100 ? -6.31312  0.24135   5.92404   1.000 24.00908 ? 102 LYS B CA  1 
ATOM   2995 C C   . LYS B 1 100 ? -4.85635  0.39254   5.50329   1.000 26.07476 ? 102 LYS B C   1 
ATOM   2996 O O   . LYS B 1 100 ? -4.55998  0.74427   4.35954   1.000 24.43197 ? 102 LYS B O   1 
ATOM   2997 C CB  . LYS B 1 100 ? -6.73173  -1.23904  5.84496   1.000 27.33295 ? 102 LYS B CB  1 
ATOM   2998 N N   . PHE B 1 101 ? -3.95593  0.16976   6.45191   1.000 23.72245 ? 103 PHE B N   1 
ATOM   2999 C CA  . PHE B 1 101 ? -2.52915  0.03047   6.17373   1.000 24.83033 ? 103 PHE B CA  1 
ATOM   3000 C C   . PHE B 1 101 ? -2.20341  -1.45175  6.05300   1.000 26.15984 ? 103 PHE B C   1 
ATOM   3001 O O   . PHE B 1 101 ? -2.52094  -2.23152  6.95445   1.000 24.79533 ? 103 PHE B O   1 
ATOM   3002 C CB  . PHE B 1 101 ? -1.68057  0.65198   7.28603   1.000 25.83761 ? 103 PHE B CB  1 
ATOM   3003 C CG  . PHE B 1 101 ? -1.77471  2.15167   7.38215   1.000 25.01847 ? 103 PHE B CG  1 
ATOM   3004 C CD1 . PHE B 1 101 ? -2.28867  2.90881   6.33732   1.000 26.41319 ? 103 PHE B CD1 1 
ATOM   3005 C CD2 . PHE B 1 101 ? -1.33193  2.80798   8.52792   1.000 23.50121 ? 103 PHE B CD2 1 
ATOM   3006 C CE1 . PHE B 1 101 ? -2.36568  4.28312   6.43385   1.000 24.90385 ? 103 PHE B CE1 1 
ATOM   3007 C CE2 . PHE B 1 101 ? -1.39762  4.18488   8.62745   1.000 23.38859 ? 103 PHE B CE2 1 
ATOM   3008 C CZ  . PHE B 1 101 ? -1.91165  4.92545   7.58280   1.000 23.81308 ? 103 PHE B CZ  1 
ATOM   3009 N N   . VAL B 1 102 ? -1.58263  -1.84368  4.93814   1.000 23.83785 ? 104 VAL B N   1 
ATOM   3010 C CA  . VAL B 1 102 ? -1.19804  -3.22838  4.71261   1.000 19.92933 ? 104 VAL B CA  1 
ATOM   3011 C C   . VAL B 1 102 ? 0.24213   -3.25135  4.20911   1.000 22.81736 ? 104 VAL B C   1 
ATOM   3012 O O   . VAL B 1 102 ? 0.72589   -2.28798  3.60733   1.000 26.97804 ? 104 VAL B O   1 
ATOM   3013 C CB  . VAL B 1 102 ? -2.14059  -3.93854  3.70423   1.000 22.65297 ? 104 VAL B CB  1 
ATOM   3014 C CG1 . VAL B 1 102 ? -3.61614  -3.77047  4.10910   1.000 30.57574 ? 104 VAL B CG1 1 
ATOM   3015 C CG2 . VAL B 1 102 ? -1.91924  -3.39308  2.31715   1.000 22.66607 ? 104 VAL B CG2 1 
ATOM   3016 N N   . ARG B 1 103 ? 0.93092   -4.35396  4.45378   1.000 23.50689 ? 105 ARG B N   1 
ATOM   3017 C CA  . ARG B 1 103 ? 2.26670   -4.55610  3.90621   1.000 26.55582 ? 105 ARG B CA  1 
ATOM   3018 C C   . ARG B 1 103 ? 2.18052   -5.63055  2.83620   1.000 25.63734 ? 105 ARG B C   1 
ATOM   3019 O O   . ARG B 1 103 ? 1.57697   -6.68100  3.06706   1.000 27.28287 ? 105 ARG B O   1 
ATOM   3020 C CB  . ARG B 1 103 ? 3.25986   -4.95227  5.00011   1.000 25.95579 ? 105 ARG B CB  1 
ATOM   3021 C CG  . ARG B 1 103 ? 4.69533   -5.08311  4.48968   1.000 23.83819 ? 105 ARG B CG  1 
ATOM   3022 C CD  . ARG B 1 103 ? 5.67336   -5.31521  5.61492   1.000 28.16696 ? 105 ARG B CD  1 
ATOM   3023 N NE  . ARG B 1 103 ? 7.03286   -5.48167  5.09967   1.000 25.57714 ? 105 ARG B NE  1 
ATOM   3024 C CZ  . ARG B 1 103 ? 7.86115   -4.47336  4.83496   1.000 29.06636 ? 105 ARG B CZ  1 
ATOM   3025 N NH1 . ARG B 1 103 ? 7.47853   -3.21610  5.02823   1.000 23.35306 ? 105 ARG B NH1 1 
ATOM   3026 N NH2 . ARG B 1 103 ? 9.07940   -4.71978  4.37614   1.000 24.78752 ? 105 ARG B NH2 1 
ATOM   3027 N N   . ILE B 1 104 ? 2.75896   -5.37092  1.66832   1.000 24.00439 ? 106 ILE B N   1 
ATOM   3028 C CA  . ILE B 1 104 ? 2.67332   -6.30266  0.56085   1.000 27.93224 ? 106 ILE B CA  1 
ATOM   3029 C C   . ILE B 1 104 ? 3.99760   -7.04824  0.43216   1.000 32.27302 ? 106 ILE B C   1 
ATOM   3030 O O   . ILE B 1 104 ? 4.97941   -6.73934  1.10597   1.000 26.53147 ? 106 ILE B O   1 
ATOM   3031 C CB  . ILE B 1 104 ? 2.27756   -5.60360  -0.76978  1.000 26.10777 ? 106 ILE B CB  1 
ATOM   3032 C CG1 . ILE B 1 104 ? 3.21637   -4.42320  -1.04957  1.000 27.30208 ? 106 ILE B CG1 1 
ATOM   3033 C CG2 . ILE B 1 104 ? 0.78990   -5.18326  -0.73261  1.000 26.67407 ? 106 ILE B CG2 1 
ATOM   3034 C CD1 . ILE B 1 104 ? 3.52989   -4.23175  -2.48262  1.000 34.51321 ? 106 ILE B CD1 1 
ATOM   3035 N N   . GLN B 1 105 ? 4.01164   -8.07065  -0.42245  1.000 32.27820 ? 107 GLN B N   1 
ATOM   3036 C CA  . GLN B 1 105 ? 5.16831   -8.92336  -0.69354  1.000 33.66662 ? 107 GLN B CA  1 
ATOM   3037 C C   . GLN B 1 105 ? 5.74483   -8.62078  -2.07044  1.000 30.68753 ? 107 GLN B C   1 
ATOM   3038 O O   . GLN B 1 105 ? 5.04156   -8.09389  -2.93952  1.000 28.53529 ? 107 GLN B O   1 
ATOM   3039 C CB  . GLN B 1 105 ? 4.77474   -10.40761 -0.64468  1.000 34.49478 ? 107 GLN B CB  1 
ATOM   3040 C CG  . GLN B 1 105 ? 4.14621   -10.87685 0.64931   1.000 40.81693 ? 107 GLN B CG  1 
ATOM   3041 C CD  . GLN B 1 105 ? 2.77224   -11.48562 0.41448   1.000 53.70322 ? 107 GLN B CD  1 
ATOM   3042 O OE1 . GLN B 1 105 ? 2.65246   -12.56874 -0.16862  1.000 59.37521 ? 107 GLN B OE1 1 
ATOM   3043 N NE2 . GLN B 1 105 ? 1.72303   -10.78429 0.85629   1.000 53.95628 ? 107 GLN B NE2 1 
ATOM   3044 N N   . PRO B 1 106 ? 7.01919   -8.95999  -2.31730  1.000 29.26048 ? 108 PRO B N   1 
ATOM   3045 C CA  . PRO B 1 106 ? 7.56886   -8.79902  -3.67031  1.000 32.66871 ? 108 PRO B CA  1 
ATOM   3046 C C   . PRO B 1 106 ? 6.71966   -9.53929  -4.68700  1.000 31.73544 ? 108 PRO B C   1 
ATOM   3047 O O   . PRO B 1 106 ? 6.21947   -10.63567 -4.42448  1.000 34.31195 ? 108 PRO B O   1 
ATOM   3048 C CB  . PRO B 1 106 ? 8.97489   -9.41159  -3.57308  1.000 32.20292 ? 108 PRO B CB  1 
ATOM   3049 C CG  . PRO B 1 106 ? 9.30655   -9.42067  -2.15182  1.000 32.04876 ? 108 PRO B CG  1 
ATOM   3050 C CD  . PRO B 1 106 ? 8.00937   -9.52802  -1.38551  1.000 32.12279 ? 108 PRO B CD  1 
ATOM   3051 N N   . GLY B 1 107 ? 6.54732   -8.91854  -5.85180  1.000 31.90540 ? 109 GLY B N   1 
ATOM   3052 C CA  . GLY B 1 107 ? 5.69189   -9.45102  -6.88417  1.000 30.58340 ? 109 GLY B CA  1 
ATOM   3053 C C   . GLY B 1 107 ? 4.27305   -8.93065  -6.86715  1.000 33.01261 ? 109 GLY B C   1 
ATOM   3054 O O   . GLY B 1 107 ? 3.58959   -8.99949  -7.89556  1.000 36.12032 ? 109 GLY B O   1 
ATOM   3055 N N   . GLN B 1 108 ? 3.79839   -8.42564  -5.73711  1.000 30.60557 ? 110 GLN B N   1 
ATOM   3056 C CA  . GLN B 1 108 ? 2.44929   -7.89147  -5.67985  1.000 26.86713 ? 110 GLN B CA  1 
ATOM   3057 C C   . GLN B 1 108 ? 2.39344   -6.49971  -6.30827  1.000 27.37282 ? 110 GLN B C   1 
ATOM   3058 O O   . GLN B 1 108 ? 3.38323   -5.75866  -6.33781  1.000 25.85804 ? 110 GLN B O   1 
ATOM   3059 C CB  . GLN B 1 108 ? 1.94765   -7.87021  -4.23622  1.000 26.08575 ? 110 GLN B CB  1 
ATOM   3060 C CG  . GLN B 1 108 ? 1.67079   -9.27697  -3.70522  1.000 36.65029 ? 110 GLN B CG  1 
ATOM   3061 C CD  . GLN B 1 108 ? 1.02563   -9.29474  -2.32814  1.000 40.94936 ? 110 GLN B CD  1 
ATOM   3062 O OE1 . GLN B 1 108 ? 1.61221   -8.84888  -1.34681  1.000 37.93016 ? 110 GLN B OE1 1 
ATOM   3063 N NE2 . GLN B 1 108 ? -0.19373  -9.82691  -2.25237  1.000 50.28735 ? 110 GLN B NE2 1 
ATOM   3064 N N   . THR B 1 109 ? 1.22557   -6.15879  -6.84292  1.000 25.26247 ? 111 THR B N   1 
ATOM   3065 C CA  . THR B 1 109 ? 1.04112   -4.93001  -7.59747  1.000 23.60085 ? 111 THR B CA  1 
ATOM   3066 C C   . THR B 1 109 ? 0.22449   -3.90628  -6.81112  1.000 25.17563 ? 111 THR B C   1 
ATOM   3067 O O   . THR B 1 109 ? -0.50483  -4.23720  -5.87001  1.000 25.04097 ? 111 THR B O   1 
ATOM   3068 C CB  . THR B 1 109 ? 0.33730   -5.22998  -8.92646  1.000 27.54704 ? 111 THR B CB  1 
ATOM   3069 O OG1 . THR B 1 109 ? -0.88067  -5.93518  -8.65536  1.000 26.16566 ? 111 THR B OG1 1 
ATOM   3070 C CG2 . THR B 1 109 ? 1.22829   -6.09705  -9.81135  1.000 26.55207 ? 111 THR B CG2 1 
ATOM   3071 N N   . PHE B 1 110 ? 0.33948   -2.65295  -7.23447  1.000 26.08871 ? 112 PHE B N   1 
ATOM   3072 C CA  . PHE B 1 110 ? -0.42367  -1.55296  -6.65858  1.000 27.41817 ? 112 PHE B CA  1 
ATOM   3073 C C   . PHE B 1 110 ? -0.26083  -0.34063  -7.56337  1.000 25.44431 ? 112 PHE B C   1 
ATOM   3074 O O   . PHE B 1 110 ? 0.60286   -0.30733  -8.44219  1.000 25.32089 ? 112 PHE B O   1 
ATOM   3075 C CB  . PHE B 1 110 ? 0.02821   -1.23075  -5.23109  1.000 21.62801 ? 112 PHE B CB  1 
ATOM   3076 C CG  . PHE B 1 110 ? 1.50757   -0.94157  -5.10614  1.000 23.89811 ? 112 PHE B CG  1 
ATOM   3077 C CD1 . PHE B 1 110 ? 2.41563   -1.97159  -4.94310  1.000 27.94640 ? 112 PHE B CD1 1 
ATOM   3078 C CD2 . PHE B 1 110 ? 1.98157   0.35991   -5.14621  1.000 22.62633 ? 112 PHE B CD2 1 
ATOM   3079 C CE1 . PHE B 1 110 ? 3.79378   -1.69898  -4.81061  1.000 29.53017 ? 112 PHE B CE1 1 
ATOM   3080 C CE2 . PHE B 1 110 ? 3.35098   0.63456   -5.01223  1.000 29.40085 ? 112 PHE B CE2 1 
ATOM   3081 C CZ  . PHE B 1 110 ? 4.24702   -0.39955  -4.84961  1.000 27.26459 ? 112 PHE B CZ  1 
ATOM   3082 N N   . SER B 1 111 ? -1.09480  0.66423   -7.32437  1.000 24.63056 ? 113 SER B N   1 
ATOM   3083 C CA  . SER B 1 111 ? -1.01954  1.92635   -8.04549  1.000 25.66314 ? 113 SER B CA  1 
ATOM   3084 C C   . SER B 1 111 ? -0.24234  2.94897   -7.23059  1.000 22.79380 ? 113 SER B C   1 
ATOM   3085 O O   . SER B 1 111 ? -0.37671  3.00807   -6.01007  1.000 24.24767 ? 113 SER B O   1 
ATOM   3086 C CB  . SER B 1 111 ? -2.42508  2.45621   -8.33781  1.000 24.65323 ? 113 SER B CB  1 
ATOM   3087 O OG  . SER B 1 111 ? -3.11832  1.55266   -9.16967  1.000 26.55100 ? 113 SER B OG  1 
ATOM   3088 N N   . VAL B 1 112 ? 0.58154   3.74102   -7.90527  1.000 24.92634 ? 114 VAL B N   1 
ATOM   3089 C CA  . VAL B 1 112 ? 1.27079   4.86492   -7.28670  1.000 24.95368 ? 114 VAL B CA  1 
ATOM   3090 C C   . VAL B 1 112 ? 0.64296   6.14278   -7.80832  1.000 23.57891 ? 114 VAL B C   1 
ATOM   3091 O O   . VAL B 1 112 ? 0.45620   6.29769   -9.02011  1.000 27.63605 ? 114 VAL B O   1 
ATOM   3092 C CB  . VAL B 1 112 ? 2.78006   4.85117   -7.57408  1.000 27.39089 ? 114 VAL B CB  1 
ATOM   3093 C CG1 . VAL B 1 112 ? 3.41364   6.16265   -7.08126  1.000 25.71162 ? 114 VAL B CG1 1 
ATOM   3094 C CG2 . VAL B 1 112 ? 3.42701   3.63390   -6.93232  1.000 27.56878 ? 114 VAL B CG2 1 
ATOM   3095 N N   . LEU B 1 113 ? 0.31106   7.05131   -6.89712  1.000 23.70554 ? 115 LEU B N   1 
ATOM   3096 C CA  . LEU B 1 113 ? -0.15490  8.38607   -7.25001  1.000 25.11116 ? 115 LEU B CA  1 
ATOM   3097 C C   . LEU B 1 113 ? 1.04581   9.30996   -7.09666  1.000 28.07861 ? 115 LEU B C   1 
ATOM   3098 O O   . LEU B 1 113 ? 1.37557   9.72762   -5.98545  1.000 26.82670 ? 115 LEU B O   1 
ATOM   3099 C CB  . LEU B 1 113 ? -1.32502  8.82784   -6.37007  1.000 23.20885 ? 115 LEU B CB  1 
ATOM   3100 C CG  . LEU B 1 113 ? -1.81329  10.25925  -6.63573  1.000 26.15473 ? 115 LEU B CG  1 
ATOM   3101 C CD1 . LEU B 1 113 ? -2.37982  10.37664  -8.05478  1.000 26.32570 ? 115 LEU B CD1 1 
ATOM   3102 C CD2 . LEU B 1 113 ? -2.86113  10.69305  -5.61313  1.000 26.30099 ? 115 LEU B CD2 1 
ATOM   3103 N N   . ALA B 1 114 ? 1.71102   9.60985   -8.21637  1.000 27.46556 ? 116 ALA B N   1 
ATOM   3104 C CA  . ALA B 1 114 ? 2.85457   10.51191  -8.18808  1.000 27.78960 ? 116 ALA B CA  1 
ATOM   3105 C C   . ALA B 1 114 ? 2.39705   11.93801  -7.90034  1.000 32.32520 ? 116 ALA B C   1 
ATOM   3106 O O   . ALA B 1 114 ? 1.47639   12.45647  -8.55114  1.000 30.34660 ? 116 ALA B O   1 
ATOM   3107 C CB  . ALA B 1 114 ? 3.61782   10.45686  -9.51228  1.000 28.55482 ? 116 ALA B CB  1 
ATOM   3108 N N   . CYS B 1 115 ? 3.04386   12.56875  -6.91716  1.000 26.43242 ? 117 CYS B N   1 
ATOM   3109 C CA  . CYS B 1 115 ? 2.68993   13.89892  -6.45363  1.000 30.23598 ? 117 CYS B CA  1 
ATOM   3110 C C   . CYS B 1 115 ? 3.93925   14.76381  -6.36366  1.000 33.96437 ? 117 CYS B C   1 
ATOM   3111 O O   . CYS B 1 115 ? 5.01552   14.27340  -6.00814  1.000 31.74876 ? 117 CYS B O   1 
ATOM   3112 C CB  . CYS B 1 115 ? 2.00973   13.83906  -5.08622  1.000 32.15565 ? 117 CYS B CB  1 
ATOM   3113 S SG  . CYS B 1 115 ? 0.43421   12.95056  -5.09284  1.000 34.26086 ? 117 CYS B SG  1 
ATOM   3114 N N   . TYR B 1 116 ? 3.78774   16.05181  -6.67485  1.000 35.19176 ? 118 TYR B N   1 
ATOM   3115 C CA  . TYR B 1 116 ? 4.84480   17.04188  -6.47895  1.000 39.43083 ? 118 TYR B CA  1 
ATOM   3116 C C   . TYR B 1 116 ? 4.32614   18.12994  -5.54676  1.000 41.78593 ? 118 TYR B C   1 
ATOM   3117 O O   . TYR B 1 116 ? 3.31812   18.78255  -5.84688  1.000 37.12684 ? 118 TYR B O   1 
ATOM   3118 C CB  . TYR B 1 116 ? 5.30858   17.64100  -7.80809  1.000 41.05765 ? 118 TYR B CB  1 
ATOM   3119 N N   . ASN B 1 117 ? 4.99731   18.29307  -4.40245  1.000 41.47120 ? 119 ASN B N   1 
ATOM   3120 C CA  . ASN B 1 117 ? 4.69065   19.35074  -3.43409  1.000 41.26178 ? 119 ASN B CA  1 
ATOM   3121 C C   . ASN B 1 117 ? 3.21430   19.34680  -3.04359  1.000 39.00005 ? 119 ASN B C   1 
ATOM   3122 O O   . ASN B 1 117 ? 2.57027   20.39458  -2.94495  1.000 44.26375 ? 119 ASN B O   1 
ATOM   3123 C CB  . ASN B 1 117 ? 5.10132   20.72360  -3.97202  1.000 44.58250 ? 119 ASN B CB  1 
ATOM   3124 C CG  . ASN B 1 117 ? 6.53575   21.08875  -3.62643  1.000 50.26333 ? 119 ASN B CG  1 
ATOM   3125 O OD1 . ASN B 1 117 ? 7.39517   20.22380  -3.43527  1.000 49.84111 ? 119 ASN B OD1 1 
ATOM   3126 N ND2 . ASN B 1 117 ? 6.79851   22.38542  -3.53995  1.000 53.19510 ? 119 ASN B ND2 1 
ATOM   3127 N N   . GLY B 1 118 ? 2.66383   18.15452  -2.82623  1.000 36.17936 ? 120 GLY B N   1 
ATOM   3128 C CA  . GLY B 1 118 ? 1.29572   18.02107  -2.37554  1.000 34.82120 ? 120 GLY B CA  1 
ATOM   3129 C C   . GLY B 1 118 ? 0.23625   17.96335  -3.45992  1.000 36.36124 ? 120 GLY B C   1 
ATOM   3130 O O   . GLY B 1 118 ? -0.93557  17.72321  -3.14086  1.000 38.02792 ? 120 GLY B O   1 
ATOM   3131 N N   . SER B 1 119 ? 0.58860   18.16710  -4.72905  1.000 36.74701 ? 121 SER B N   1 
ATOM   3132 C CA  . SER B 1 119 ? -0.46073  18.09779  -5.74245  1.000 37.90940 ? 121 SER B CA  1 
ATOM   3133 C C   . SER B 1 119 ? -0.24343  16.90812  -6.66460  1.000 36.61187 ? 121 SER B C   1 
ATOM   3134 O O   . SER B 1 119 ? 0.86215   16.71236  -7.19732  1.000 33.05018 ? 121 SER B O   1 
ATOM   3135 C CB  . SER B 1 119 ? -0.52980  19.38809  -6.56385  1.000 39.43458 ? 121 SER B CB  1 
ATOM   3136 O OG  . SER B 1 119 ? 0.66683   19.58484  -7.27722  1.000 47.64026 ? 121 SER B OG  1 
ATOM   3137 N N   . PRO B 1 120 ? -1.27289  16.09578  -6.86210  1.000 34.21560 ? 122 PRO B N   1 
ATOM   3138 C CA  . PRO B 1 120 ? -1.11068  14.87947  -7.66500  1.000 31.38476 ? 122 PRO B CA  1 
ATOM   3139 C C   . PRO B 1 120 ? -0.81619  15.20877  -9.11930  1.000 33.71717 ? 122 PRO B C   1 
ATOM   3140 O O   . PRO B 1 120 ? -1.44167  16.08335  -9.72086  1.000 34.12554 ? 122 PRO B O   1 
ATOM   3141 C CB  . PRO B 1 120 ? -2.46091  14.16936  -7.50101  1.000 33.61092 ? 122 PRO B CB  1 
ATOM   3142 C CG  . PRO B 1 120 ? -3.06091  14.76150  -6.23425  1.000 35.12199 ? 122 PRO B CG  1 
ATOM   3143 C CD  . PRO B 1 120 ? -2.59480  16.18017  -6.22182  1.000 33.46899 ? 122 PRO B CD  1 
ATOM   3144 N N   . SER B 1 121 ? 0.14903   14.49402  -9.68052  1.000 29.70997 ? 123 SER B N   1 
ATOM   3145 C CA  . SER B 1 121 ? 0.58698   14.68378  -11.05676 1.000 29.11129 ? 123 SER B CA  1 
ATOM   3146 C C   . SER B 1 121 ? 0.10750   13.58662  -11.99552 1.000 28.59174 ? 123 SER B C   1 
ATOM   3147 O O   . SER B 1 121 ? -0.32574  13.88379  -13.11726 1.000 29.93724 ? 123 SER B O   1 
ATOM   3148 C CB  . SER B 1 121 ? 2.12480   14.76569  -11.09634 1.000 29.28535 ? 123 SER B CB  1 
ATOM   3149 O OG  . SER B 1 121 ? 2.62369   14.69212  -12.41942 1.000 44.63071 ? 123 SER B OG  1 
ATOM   3150 N N   . GLY B 1 122 ? 0.15716   12.32770  -11.56171 1.000 27.51292 ? 124 GLY B N   1 
ATOM   3151 C CA  . GLY B 1 122 ? -0.20658  11.20327  -12.41096 1.000 29.94170 ? 124 GLY B CA  1 
ATOM   3152 C C   . GLY B 1 122 ? -0.34134  9.94843   -11.57543 1.000 30.31388 ? 124 GLY B C   1 
ATOM   3153 O O   . GLY B 1 122 ? 0.03034   9.92103   -10.39932 1.000 30.32928 ? 124 GLY B O   1 
ATOM   3154 N N   . VAL B 1 123 ? -0.89022  8.90221   -12.19827 1.000 24.49038 ? 125 VAL B N   1 
ATOM   3155 C CA  . VAL B 1 123 ? -1.03568  7.60503   -11.55244 1.000 25.91818 ? 125 VAL B CA  1 
ATOM   3156 C C   . VAL B 1 123 ? -0.52052  6.51623   -12.48956 1.000 27.98235 ? 125 VAL B C   1 
ATOM   3157 O O   . VAL B 1 123 ? -0.70494  6.58737   -13.71040 1.000 29.43088 ? 125 VAL B O   1 
ATOM   3158 C CB  . VAL B 1 123 ? -2.50199  7.34520   -11.12345 1.000 27.31330 ? 125 VAL B CB  1 
ATOM   3159 C CG1 . VAL B 1 123 ? -3.42519  7.26981   -12.32401 1.000 27.44505 ? 125 VAL B CG1 1 
ATOM   3160 C CG2 . VAL B 1 123 ? -2.60354  6.08559   -10.27939 1.000 26.05186 ? 125 VAL B CG2 1 
ATOM   3161 N N   . TYR B 1 124 ? 0.16036   5.52103   -11.92362 1.000 27.24266 ? 126 TYR B N   1 
ATOM   3162 C CA  . TYR B 1 124 ? 0.60493   4.38278   -12.71550 1.000 26.22471 ? 126 TYR B CA  1 
ATOM   3163 C C   . TYR B 1 124 ? 0.52078   3.11188   -11.88554 1.000 26.05297 ? 126 TYR B C   1 
ATOM   3164 O O   . TYR B 1 124 ? 0.53635   3.14152   -10.65387 1.000 28.39381 ? 126 TYR B O   1 
ATOM   3165 C CB  . TYR B 1 124 ? 2.03319   4.57490   -13.26346 1.000 27.80556 ? 126 TYR B CB  1 
ATOM   3166 C CG  . TYR B 1 124 ? 3.12507   4.78591   -12.22741 1.000 27.19509 ? 126 TYR B CG  1 
ATOM   3167 C CD1 . TYR B 1 124 ? 3.35740   6.03939   -11.67308 1.000 28.21509 ? 126 TYR B CD1 1 
ATOM   3168 C CD2 . TYR B 1 124 ? 3.96016   3.73813   -11.85142 1.000 36.76955 ? 126 TYR B CD2 1 
ATOM   3169 C CE1 . TYR B 1 124 ? 4.38553   6.23929   -10.73159 1.000 29.85272 ? 126 TYR B CE1 1 
ATOM   3170 C CE2 . TYR B 1 124 ? 4.99762   3.92560   -10.92786 1.000 35.71539 ? 126 TYR B CE2 1 
ATOM   3171 C CZ  . TYR B 1 124 ? 5.20137   5.17568   -10.37254 1.000 36.40205 ? 126 TYR B CZ  1 
ATOM   3172 O OH  . TYR B 1 124 ? 6.22139   5.34678   -9.45317  1.000 36.56190 ? 126 TYR B OH  1 
ATOM   3173 N N   . GLN B 1 125 ? 0.42058   1.99108   -12.58977 1.000 26.32135 ? 127 GLN B N   1 
ATOM   3174 C CA  . GLN B 1 125 ? 0.38195   0.66948   -11.99276 1.000 26.67235 ? 127 GLN B CA  1 
ATOM   3175 C C   . GLN B 1 125 ? 1.78452   0.07449   -12.04331 1.000 28.02057 ? 127 GLN B C   1 
ATOM   3176 O O   . GLN B 1 125 ? 2.48996   0.21083   -13.04446 1.000 29.78201 ? 127 GLN B O   1 
ATOM   3177 C CB  . GLN B 1 125 ? -0.61511  -0.22758  -12.73222 1.000 28.37557 ? 127 GLN B CB  1 
ATOM   3178 C CG  . GLN B 1 125 ? -0.80912  -1.63312  -12.13741 1.000 28.73878 ? 127 GLN B CG  1 
ATOM   3179 C CD  . GLN B 1 125 ? -1.69995  -1.65200  -10.90373 1.000 27.85205 ? 127 GLN B CD  1 
ATOM   3180 O OE1 . GLN B 1 125 ? -2.09153  -0.59718  -10.38290 1.000 28.36847 ? 127 GLN B OE1 1 
ATOM   3181 N NE2 . GLN B 1 125 ? -2.02808  -2.85435  -10.42426 1.000 27.55001 ? 127 GLN B NE2 1 
ATOM   3182 N N   . CYS B 1 126 ? 2.19880   -0.56028  -10.95498 1.000 26.19901 ? 128 CYS B N   1 
ATOM   3183 C CA  . CYS B 1 126 ? 3.53040   -1.14311  -10.90374 1.000 30.25035 ? 128 CYS B CA  1 
ATOM   3184 C C   . CYS B 1 126 ? 3.48406   -2.40259  -10.04867 1.000 33.00197 ? 128 CYS B C   1 
ATOM   3185 O O   . CYS B 1 126 ? 2.45022   -2.74787  -9.47045  1.000 27.95510 ? 128 CYS B O   1 
ATOM   3186 C CB  . CYS B 1 126 ? 4.54148   -0.13036  -10.35440 1.000 32.28525 ? 128 CYS B CB  1 
ATOM   3187 S SG  . CYS B 1 126 ? 4.25074   0.19700   -8.60751  1.000 34.50102 ? 128 CYS B SG  1 
ATOM   3188 N N   . ALA B 1 127 ? 4.62086   -3.09291  -9.97676  1.000 29.02395 ? 129 ALA B N   1 
ATOM   3189 C CA  . ALA B 1 127 ? 4.81142   -4.22432  -9.08552  1.000 29.87279 ? 129 ALA B CA  1 
ATOM   3190 C C   . ALA B 1 127 ? 5.98945   -3.95520  -8.15234  1.000 31.94966 ? 129 ALA B C   1 
ATOM   3191 O O   . ALA B 1 127 ? 6.95728   -3.29150  -8.52738  1.000 31.21998 ? 129 ALA B O   1 
ATOM   3192 C CB  . ALA B 1 127 ? 5.06834   -5.52290  -9.86710  1.000 32.69381 ? 129 ALA B CB  1 
ATOM   3193 N N   . MET B 1 128 ? 5.89035   -4.45944  -6.92438  1.000 27.66443 ? 130 MET B N   1 
ATOM   3194 C CA  . MET B 1 128 ? 7.04798   -4.51454  -6.03471  1.000 32.52973 ? 130 MET B CA  1 
ATOM   3195 C C   . MET B 1 128 ? 8.02261   -5.53897  -6.60076  1.000 28.58305 ? 130 MET B C   1 
ATOM   3196 O O   . MET B 1 128 ? 7.71105   -6.73453  -6.64102  1.000 32.70473 ? 130 MET B O   1 
ATOM   3197 C CB  . MET B 1 128 ? 6.60704   -4.88455  -4.62045  1.000 31.21088 ? 130 MET B CB  1 
ATOM   3198 C CG  . MET B 1 128 ? 7.74223   -5.13574  -3.60299  1.000 36.30417 ? 130 MET B CG  1 
ATOM   3199 S SD  . MET B 1 128 ? 8.50252   -3.60896  -3.06816  1.000 37.91920 ? 130 MET B SD  1 
ATOM   3200 C CE  . MET B 1 128 ? 7.12788   -2.79388  -2.25001  1.000 28.14937 ? 130 MET B CE  1 
ATOM   3201 N N   . ARG B 1 129 ? 9.16626   -5.06504  -7.09410  1.000 31.23128 ? 131 ARG B N   1 
ATOM   3202 C CA  . ARG B 1 129 ? 10.15914  -5.94241  -7.70709  1.000 31.93840 ? 131 ARG B CA  1 
ATOM   3203 C C   . ARG B 1 129 ? 10.71288  -6.91781  -6.66949  1.000 31.84167 ? 131 ARG B C   1 
ATOM   3204 O O   . ARG B 1 129 ? 10.60388  -6.68257  -5.46122  1.000 28.77306 ? 131 ARG B O   1 
ATOM   3205 C CB  . ARG B 1 129 ? 11.30039  -5.12959  -8.31711  1.000 32.12002 ? 131 ARG B CB  1 
ATOM   3206 C CG  . ARG B 1 129 ? 10.91653  -4.12684  -9.40470  1.000 34.75960 ? 131 ARG B CG  1 
ATOM   3207 C CD  . ARG B 1 129 ? 10.01668  -4.71907  -10.49220 1.000 33.93070 ? 131 ARG B CD  1 
ATOM   3208 N NE  . ARG B 1 129 ? 10.58631  -5.93455  -11.06890 1.000 35.64633 ? 131 ARG B NE  1 
ATOM   3209 C CZ  . ARG B 1 129 ? 9.95544   -6.72563  -11.93503 1.000 36.06322 ? 131 ARG B CZ  1 
ATOM   3210 N NH1 . ARG B 1 129 ? 8.71824   -6.42934  -12.33610 1.000 27.95451 ? 131 ARG B NH1 1 
ATOM   3211 N NH2 . ARG B 1 129 ? 10.56169  -7.81762  -12.39468 1.000 31.31902 ? 131 ARG B NH2 1 
ATOM   3212 N N   . PRO B 1 130 ? 11.26894  -8.05103  -7.11798  1.000 32.65862 ? 132 PRO B N   1 
ATOM   3213 C CA  . PRO B 1 130 ? 11.90799  -8.97551  -6.16417  1.000 32.71484 ? 132 PRO B CA  1 
ATOM   3214 C C   . PRO B 1 130 ? 13.03861  -8.33801  -5.37054  1.000 29.83689 ? 132 PRO B C   1 
ATOM   3215 O O   . PRO B 1 130 ? 13.30609  -8.76666  -4.23910  1.000 32.88453 ? 132 PRO B O   1 
ATOM   3216 C CB  . PRO B 1 130 ? 12.41849  -10.11070 -7.06722  1.000 32.56192 ? 132 PRO B CB  1 
ATOM   3217 C CG  . PRO B 1 130 ? 11.43243  -10.12505 -8.19648  1.000 37.22986 ? 132 PRO B CG  1 
ATOM   3218 C CD  . PRO B 1 130 ? 11.08187  -8.66932  -8.44593  1.000 32.60208 ? 132 PRO B CD  1 
ATOM   3219 N N   . ASN B 1 131 ? 13.71081  -7.32908  -5.92088  1.000 31.31320 ? 133 ASN B N   1 
ATOM   3220 C CA  . ASN B 1 131 ? 14.77312  -6.64129  -5.18873  1.000 32.68709 ? 133 ASN B CA  1 
ATOM   3221 C C   . ASN B 1 131 ? 14.23299  -5.50661  -4.32886  1.000 32.68052 ? 133 ASN B C   1 
ATOM   3222 O O   . ASN B 1 131 ? 15.01226  -4.66330  -3.86387  1.000 29.77078 ? 133 ASN B O   1 
ATOM   3223 C CB  . ASN B 1 131 ? 15.83991  -6.11487  -6.15600  1.000 31.27168 ? 133 ASN B CB  1 
ATOM   3224 C CG  . ASN B 1 131 ? 15.32153  -5.00178  -7.06650  1.000 34.77121 ? 133 ASN B CG  1 
ATOM   3225 O OD1 . ASN B 1 131 ? 14.16315  -4.57418  -6.97196  1.000 29.05715 ? 133 ASN B OD1 1 
ATOM   3226 N ND2 . ASN B 1 131 ? 16.18330  -4.53495  -7.96066  1.000 30.40719 ? 133 ASN B ND2 1 
ATOM   3227 N N   . PHE B 1 132 ? 12.90549  -5.44036  -4.16996  1.000 30.48077 ? 134 PHE B N   1 
ATOM   3228 C CA  . PHE B 1 132 ? 12.23446  -4.51955  -3.26015  1.000 34.01555 ? 134 PHE B CA  1 
ATOM   3229 C C   . PHE B 1 132 ? 12.32074  -3.06666  -3.71553  1.000 32.41534 ? 134 PHE B C   1 
ATOM   3230 O O   . PHE B 1 132 ? 12.23281  -2.15305  -2.89884  1.000 41.50204 ? 134 PHE B O   1 
ATOM   3231 C CB  . PHE B 1 132 ? 12.77505  -4.65243  -1.83684  1.000 28.07965 ? 134 PHE B CB  1 
ATOM   3232 C CG  . PHE B 1 132 ? 12.30519  -5.88201  -1.11552  1.000 27.88675 ? 134 PHE B CG  1 
ATOM   3233 C CD1 . PHE B 1 132 ? 11.00879  -5.97507  -0.64909  1.000 34.18194 ? 134 PHE B CD1 1 
ATOM   3234 C CD2 . PHE B 1 132 ? 13.16601  -6.94837  -0.90053  1.000 35.18411 ? 134 PHE B CD2 1 
ATOM   3235 C CE1 . PHE B 1 132 ? 10.57628  -7.10468  0.01591   1.000 35.34012 ? 134 PHE B CE1 1 
ATOM   3236 C CE2 . PHE B 1 132 ? 12.73812  -8.08093  -0.22774  1.000 30.98485 ? 134 PHE B CE2 1 
ATOM   3237 C CZ  . PHE B 1 132 ? 11.44608  -8.15802  0.22597   1.000 37.71102 ? 134 PHE B CZ  1 
ATOM   3238 N N   . THR B 1 133 ? 12.46971  -2.81854  -5.00389  1.000 29.16200 ? 135 THR B N   1 
ATOM   3239 C CA  . THR B 1 133 ? 12.35523  -1.46829  -5.52938  1.000 26.60259 ? 135 THR B CA  1 
ATOM   3240 C C   . THR B 1 133 ? 11.12618  -1.36992  -6.42362  1.000 31.27308 ? 135 THR B C   1 
ATOM   3241 O O   . THR B 1 133 ? 10.50753  -2.37392  -6.78193  1.000 32.99069 ? 135 THR B O   1 
ATOM   3242 C CB  . THR B 1 133 ? 13.60202  -1.07018  -6.31891  1.000 32.85040 ? 135 THR B CB  1 
ATOM   3243 O OG1 . THR B 1 133 ? 13.69127  -1.88448  -7.50078  1.000 30.95625 ? 135 THR B OG1 1 
ATOM   3244 C CG2 . THR B 1 133 ? 14.87008  -1.23852  -5.43771  1.000 29.73902 ? 135 THR B CG2 1 
ATOM   3245 N N   . ILE B 1 134 ? 10.79550  -0.13546  -6.78463  1.000 30.44517 ? 136 ILE B N   1 
ATOM   3246 C CA  . ILE B 1 134 ? 9.65985   0.19042   -7.64051  1.000 34.25621 ? 136 ILE B CA  1 
ATOM   3247 C C   . ILE B 1 134 ? 10.18646  0.99956   -8.80860  1.000 38.02033 ? 136 ILE B C   1 
ATOM   3248 O O   . ILE B 1 134 ? 10.96926  1.93172   -8.60651  1.000 37.52517 ? 136 ILE B O   1 
ATOM   3249 C CB  . ILE B 1 134 ? 8.59575   1.00163   -6.88030  1.000 35.78444 ? 136 ILE B CB  1 
ATOM   3250 C CG1 . ILE B 1 134 ? 8.22822   0.29874   -5.57904  1.000 39.29021 ? 136 ILE B CG1 1 
ATOM   3251 C CG2 . ILE B 1 134 ? 7.37729   1.21103   -7.74598  1.000 42.90811 ? 136 ILE B CG2 1 
ATOM   3252 C CD1 . ILE B 1 134 ? 7.55844   -1.02525  -5.80997  1.000 33.21455 ? 136 ILE B CD1 1 
ATOM   3253 N N   . LYS B 1 135 ? 9.74666   0.66768   -10.01994 1.000 40.84801 ? 137 LYS B N   1 
ATOM   3254 C CA  . LYS B 1 135 ? 10.15953  1.44617   -11.18184 1.000 45.71299 ? 137 LYS B CA  1 
ATOM   3255 C C   . LYS B 1 135 ? 9.74941   2.90472   -11.00551 1.000 46.98291 ? 137 LYS B C   1 
ATOM   3256 O O   . LYS B 1 135 ? 8.62944   3.20993   -10.58248 1.000 53.45836 ? 137 LYS B O   1 
ATOM   3257 C CB  . LYS B 1 135 ? 9.55351   0.86985   -12.45857 1.000 52.98205 ? 137 LYS B CB  1 
ATOM   3258 N N   . GLY B 1 136 ? 10.67276  3.80598   -11.32842 1.000 50.02131 ? 138 GLY B N   1 
ATOM   3259 C CA  . GLY B 1 136 ? 10.56902  5.17384   -10.86253 1.000 52.14520 ? 138 GLY B CA  1 
ATOM   3260 C C   . GLY B 1 136 ? 9.46461   5.96909   -11.53347 1.000 54.86876 ? 138 GLY B C   1 
ATOM   3261 O O   . GLY B 1 136 ? 9.03247   5.68429   -12.65096 1.000 53.56348 ? 138 GLY B O   1 
ATOM   3262 N N   . SER B 1 137 ? 8.99832   6.98913   -10.80835 1.000 54.02991 ? 139 SER B N   1 
ATOM   3263 C CA  . SER B 1 137 ? 8.14049   8.00244   -11.41168 1.000 59.04846 ? 139 SER B CA  1 
ATOM   3264 C C   . SER B 1 137 ? 8.95286   8.96889   -12.26175 1.000 61.39801 ? 139 SER B C   1 
ATOM   3265 O O   . SER B 1 137 ? 8.42311   9.55256   -13.21589 1.000 59.12839 ? 139 SER B O   1 
ATOM   3266 C CB  . SER B 1 137 ? 7.38732   8.76811   -10.32166 1.000 52.47273 ? 139 SER B CB  1 
ATOM   3267 O OG  . SER B 1 137 ? 8.29531   9.45616   -9.47722  1.000 54.84159 ? 139 SER B OG  1 
ATOM   3268 N N   . PHE B 1 138 ? 10.23552  9.14048   -11.92281 1.000 61.34754 ? 140 PHE B N   1 
ATOM   3269 C CA  . PHE B 1 138 ? 11.13312  10.09592  -12.57722 1.000 62.72365 ? 140 PHE B CA  1 
ATOM   3270 C C   . PHE B 1 138 ? 10.58398  11.51655  -12.50234 1.000 61.24393 ? 140 PHE B C   1 
ATOM   3271 O O   . PHE B 1 138 ? 10.63150  12.27460  -13.47350 1.000 59.66384 ? 140 PHE B O   1 
ATOM   3272 C CB  . PHE B 1 138 ? 11.42812  9.67880   -14.02092 1.000 61.71661 ? 140 PHE B CB  1 
ATOM   3273 C CG  . PHE B 1 138 ? 12.39210  8.53079   -14.11771 1.000 63.62419 ? 140 PHE B CG  1 
ATOM   3274 C CD1 . PHE B 1 138 ? 11.97978  7.23625   -13.83314 1.000 60.96260 ? 140 PHE B CD1 1 
ATOM   3275 C CD2 . PHE B 1 138 ? 13.72547  8.75165   -14.43454 1.000 66.01210 ? 140 PHE B CD2 1 
ATOM   3276 C CE1 . PHE B 1 138 ? 12.86677  6.17719   -13.90679 1.000 62.57065 ? 140 PHE B CE1 1 
ATOM   3277 C CE2 . PHE B 1 138 ? 14.62413  7.69864   -14.50352 1.000 64.23704 ? 140 PHE B CE2 1 
ATOM   3278 C CZ  . PHE B 1 138 ? 14.19511  6.40849   -14.23650 1.000 64.08907 ? 140 PHE B CZ  1 
ATOM   3279 N N   . LEU B 1 139 ? 10.05979  11.86830  -11.32748 1.000 60.75768 ? 141 LEU B N   1 
ATOM   3280 C CA  . LEU B 1 139 ? 9.49331   13.18378  -11.05771 1.000 59.33604 ? 141 LEU B CA  1 
ATOM   3281 C C   . LEU B 1 139 ? 10.14916  13.72772  -9.79456  1.000 56.95276 ? 141 LEU B C   1 
ATOM   3282 O O   . LEU B 1 139 ? 10.04377  13.11179  -8.72756  1.000 52.48081 ? 141 LEU B O   1 
ATOM   3283 C CB  . LEU B 1 139 ? 7.96709   13.10756  -10.90761 1.000 57.75162 ? 141 LEU B CB  1 
ATOM   3284 C CG  . LEU B 1 139 ? 7.20198   14.27649  -10.26660 1.000 61.31707 ? 141 LEU B CG  1 
ATOM   3285 C CD1 . LEU B 1 139 ? 7.42814   15.51561  -11.10948 1.000 60.39942 ? 141 LEU B CD1 1 
ATOM   3286 C CD2 . LEU B 1 139 ? 5.70850   13.98130  -10.14052 1.000 61.21633 ? 141 LEU B CD2 1 
ATOM   3287 N N   . ALA B 1 140 ? 10.84647  14.86060  -9.92220  1.000 55.92678 ? 142 ALA B N   1 
ATOM   3288 C CA  . ALA B 1 140 ? 11.47060  15.47461  -8.76018  1.000 53.04172 ? 142 ALA B CA  1 
ATOM   3289 C C   . ALA B 1 140 ? 10.41160  15.80343  -7.71808  1.000 51.84995 ? 142 ALA B C   1 
ATOM   3290 O O   . ALA B 1 140 ? 9.26469   16.12834  -8.04597  1.000 54.25252 ? 142 ALA B O   1 
ATOM   3291 C CB  . ALA B 1 140 ? 12.22963  16.72953  -9.16596  1.000 57.16908 ? 142 ALA B CB  1 
ATOM   3292 N N   . GLY B 1 141 ? 10.79958  15.70581  -6.45221  1.000 50.13932 ? 143 GLY B N   1 
ATOM   3293 C CA  . GLY B 1 141 ? 9.88721   16.02942  -5.37672  1.000 47.51051 ? 143 GLY B CA  1 
ATOM   3294 C C   . GLY B 1 141 ? 8.82300   14.99178  -5.10786  1.000 39.56807 ? 143 GLY B C   1 
ATOM   3295 O O   . GLY B 1 141 ? 7.81949   15.30503  -4.45661  1.000 44.34447 ? 143 GLY B O   1 
ATOM   3296 N N   . SER B 1 142 ? 9.01366   13.75667  -5.57293  1.000 37.95540 ? 144 SER B N   1 
ATOM   3297 C CA  . SER B 1 142 ? 7.98838   12.73108  -5.42294  1.000 42.45457 ? 144 SER B CA  1 
ATOM   3298 C C   . SER B 1 142 ? 7.96725   12.08847  -4.04053  1.000 36.36056 ? 144 SER B C   1 
ATOM   3299 O O   . SER B 1 142 ? 7.03063   11.32744  -3.75915  1.000 32.33879 ? 144 SER B O   1 
ATOM   3300 C CB  . SER B 1 142 ? 8.17413   11.64211  -6.47953  1.000 39.12683 ? 144 SER B CB  1 
ATOM   3301 O OG  . SER B 1 142 ? 9.38922   10.94978  -6.25899  1.000 48.00112 ? 144 SER B OG  1 
ATOM   3302 N N   . CYS B 1 143 ? 8.97180   12.35486  -3.19092  1.000 33.91385 ? 145 CYS B N   1 
ATOM   3303 C CA  . CYS B 1 143 ? 9.01055   11.77757  -1.85055  1.000 33.86508 ? 145 CYS B CA  1 
ATOM   3304 C C   . CYS B 1 143 ? 7.68533   11.98654  -1.13366  1.000 27.97984 ? 145 CYS B C   1 
ATOM   3305 O O   . CYS B 1 143 ? 7.12973   13.08757  -1.12329  1.000 27.66874 ? 145 CYS B O   1 
ATOM   3306 C CB  . CYS B 1 143 ? 10.14921  12.38887  -1.01567  1.000 31.29560 ? 145 CYS B CB  1 
ATOM   3307 S SG  . CYS B 1 143 ? 11.80185  12.13121  -1.67444  1.000 38.70586 ? 145 CYS B SG  1 
ATOM   3308 N N   . GLY B 1 144 ? 7.20144   10.92528  -0.50719  1.000 27.03832 ? 146 GLY B N   1 
ATOM   3309 C CA  . GLY B 1 144 ? 5.92127   10.94924  0.15152   1.000 28.54522 ? 146 GLY B CA  1 
ATOM   3310 C C   . GLY B 1 144 ? 4.75114   10.49229  -0.69927  1.000 29.46245 ? 146 GLY B C   1 
ATOM   3311 O O   . GLY B 1 144 ? 3.65335   10.33220  -0.15718  1.000 27.70067 ? 146 GLY B O   1 
ATOM   3312 N N   . SER B 1 145 ? 4.93739   10.28523  -2.00784  1.000 27.17201 ? 147 SER B N   1 
ATOM   3313 C CA  . SER B 1 145 ? 3.85268   9.72838   -2.81927  1.000 27.74586 ? 147 SER B CA  1 
ATOM   3314 C C   . SER B 1 145 ? 3.52955   8.31491   -2.33798  1.000 28.89603 ? 147 SER B C   1 
ATOM   3315 O O   . SER B 1 145 ? 4.40717   7.58602   -1.86796  1.000 25.98314 ? 147 SER B O   1 
ATOM   3316 C CB  . SER B 1 145 ? 4.23325   9.69908   -4.30416  1.000 30.02086 ? 147 SER B CB  1 
ATOM   3317 O OG  . SER B 1 145 ? 4.55893   10.98854  -4.81546  1.000 31.56838 ? 147 SER B OG  1 
ATOM   3318 N N   . VAL B 1 146 ? 2.25880   7.91850   -2.43643  1.000 23.90097 ? 148 VAL B N   1 
ATOM   3319 C CA  . VAL B 1 146 ? 1.85789   6.64944   -1.83898  1.000 23.94738 ? 148 VAL B CA  1 
ATOM   3320 C C   . VAL B 1 146 ? 1.38510   5.65908   -2.89728  1.000 24.08091 ? 148 VAL B C   1 
ATOM   3321 O O   . VAL B 1 146 ? 0.95167   6.02206   -3.99802  1.000 26.68825 ? 148 VAL B O   1 
ATOM   3322 C CB  . VAL B 1 146 ? 0.77590   6.81955   -0.75012  1.000 27.25045 ? 148 VAL B CB  1 
ATOM   3323 C CG1 . VAL B 1 146 ? 1.31880   7.71169   0.38716   1.000 29.00531 ? 148 VAL B CG1 1 
ATOM   3324 C CG2 . VAL B 1 146 ? -0.48203  7.38093   -1.34149  1.000 25.08338 ? 148 VAL B CG2 1 
ATOM   3325 N N   . GLY B 1 147 ? 1.47913   4.37904   -2.52542  1.000 22.34567 ? 149 GLY B N   1 
ATOM   3326 C CA  . GLY B 1 147 ? 1.00795   3.27240   -3.33336  1.000 23.89115 ? 149 GLY B CA  1 
ATOM   3327 C C   . GLY B 1 147 ? -0.15928  2.59389   -2.63868  1.000 23.09831 ? 149 GLY B C   1 
ATOM   3328 O O   . GLY B 1 147 ? -0.24409  2.58198   -1.40390  1.000 23.17464 ? 149 GLY B O   1 
ATOM   3329 N N   . PHE B 1 148 ? -1.06196  2.02196   -3.43352  1.000 23.29103 ? 150 PHE B N   1 
ATOM   3330 C CA  . PHE B 1 148 ? -2.31982  1.56301   -2.86399  1.000 23.24011 ? 150 PHE B CA  1 
ATOM   3331 C C   . PHE B 1 148 ? -3.01517  0.59040   -3.80522  1.000 24.57636 ? 150 PHE B C   1 
ATOM   3332 O O   . PHE B 1 148 ? -2.77331  0.57269   -5.01544  1.000 22.91267 ? 150 PHE B O   1 
ATOM   3333 C CB  . PHE B 1 148 ? -3.23992  2.75721   -2.57193  1.000 24.06126 ? 150 PHE B CB  1 
ATOM   3334 C CG  . PHE B 1 148 ? -3.58431  3.55517   -3.79766  1.000 26.27730 ? 150 PHE B CG  1 
ATOM   3335 C CD1 . PHE B 1 148 ? -2.71125  4.51977   -4.28512  1.000 26.62873 ? 150 PHE B CD1 1 
ATOM   3336 C CD2 . PHE B 1 148 ? -4.77388  3.32080   -4.48147  1.000 26.72423 ? 150 PHE B CD2 1 
ATOM   3337 C CE1 . PHE B 1 148 ? -3.01553  5.24668   -5.43487  1.000 27.84810 ? 150 PHE B CE1 1 
ATOM   3338 C CE2 . PHE B 1 148 ? -5.08782  4.04936   -5.62477  1.000 25.70984 ? 150 PHE B CE2 1 
ATOM   3339 C CZ  . PHE B 1 148 ? -4.21183  5.00377   -6.10380  1.000 25.37823 ? 150 PHE B CZ  1 
ATOM   3340 N N   . ASN B 1 149 ? -3.90714  -0.20276  -3.21713  1.000 24.19363 ? 151 ASN B N   1 
ATOM   3341 C CA  . ASN B 1 149 ? -4.91499  -0.98031  -3.92450  1.000 26.63857 ? 151 ASN B CA  1 
ATOM   3342 C C   . ASN B 1 149 ? -6.26767  -0.52490  -3.41492  1.000 24.01506 ? 151 ASN B C   1 
ATOM   3343 O O   . ASN B 1 149 ? -6.37104  -0.04200  -2.28604  1.000 25.26085 ? 151 ASN B O   1 
ATOM   3344 C CB  . ASN B 1 149 ? -4.77856  -2.48775  -3.66751  1.000 26.07310 ? 151 ASN B CB  1 
ATOM   3345 C CG  . ASN B 1 149 ? -3.63217  -3.10904  -4.43415  1.000 29.46538 ? 151 ASN B CG  1 
ATOM   3346 O OD1 . ASN B 1 149 ? -3.81446  -3.58651  -5.55881  1.000 30.67507 ? 151 ASN B OD1 1 
ATOM   3347 N ND2 . ASN B 1 149 ? -2.44899  -3.11792  -3.82720  1.000 24.82344 ? 151 ASN B ND2 1 
ATOM   3348 N N   . ILE B 1 150 ? -7.30101  -0.68375  -4.23663  1.000 25.26925 ? 152 ILE B N   1 
ATOM   3349 C CA  . ILE B 1 150 ? -8.67346  -0.38741  -3.82563  1.000 26.96542 ? 152 ILE B CA  1 
ATOM   3350 C C   . ILE B 1 150 ? -9.50356  -1.65454  -3.95285  1.000 29.15529 ? 152 ILE B C   1 
ATOM   3351 O O   . ILE B 1 150 ? -9.50284  -2.30454  -5.00475  1.000 30.57578 ? 152 ILE B O   1 
ATOM   3352 C CB  . ILE B 1 150 ? -9.30268  0.75677   -4.64182  1.000 24.37009 ? 152 ILE B CB  1 
ATOM   3353 C CG1 . ILE B 1 150 ? -8.43614  2.01388   -4.57570  1.000 28.59978 ? 152 ILE B CG1 1 
ATOM   3354 C CG2 . ILE B 1 150 ? -10.71574 1.08085   -4.08068  1.000 31.55154 ? 152 ILE B CG2 1 
ATOM   3355 C CD1 . ILE B 1 150 ? -9.04821  3.20255   -5.26914  1.000 28.47929 ? 152 ILE B CD1 1 
ATOM   3356 N N   . ASP B 1 151 ? -10.21004 -1.99857  -2.88203  1.000 31.51500 ? 153 ASP B N   1 
ATOM   3357 C CA  . ASP B 1 151 ? -11.08024 -3.16994  -2.83590  1.000 39.56081 ? 153 ASP B CA  1 
ATOM   3358 C C   . ASP B 1 151 ? -12.42487 -2.71698  -2.27494  1.000 40.66842 ? 153 ASP B C   1 
ATOM   3359 O O   . ASP B 1 151 ? -12.51751 -2.37439  -1.09157  1.000 41.80109 ? 153 ASP B O   1 
ATOM   3360 C CB  . ASP B 1 151 ? -10.44888 -4.27344  -1.97953  1.000 42.94310 ? 153 ASP B CB  1 
ATOM   3361 C CG  . ASP B 1 151 ? -8.96699  -4.51532  -2.32590  1.000 49.73937 ? 153 ASP B CG  1 
ATOM   3362 O OD1 . ASP B 1 151 ? -8.69663  -5.17583  -3.35657  1.000 50.96753 ? 153 ASP B OD1 1 
ATOM   3363 O OD2 . ASP B 1 151 ? -8.06704  -4.02253  -1.58966  1.000 48.74797 ? 153 ASP B OD2 1 
ATOM   3364 N N   . TYR B 1 152 ? -13.45228 -2.68192  -3.12582  1.000 43.46040 ? 154 TYR B N   1 
ATOM   3365 C CA  . TYR B 1 152 ? -14.80802 -2.24963  -2.74879  1.000 46.03891 ? 154 TYR B CA  1 
ATOM   3366 C C   . TYR B 1 152 ? -14.78991 -0.97063  -1.90444  1.000 45.18586 ? 154 TYR B C   1 
ATOM   3367 O O   . TYR B 1 152 ? -15.21269 -0.94439  -0.74761  1.000 50.37089 ? 154 TYR B O   1 
ATOM   3368 C CB  . TYR B 1 152 ? -15.55070 -3.37269  -2.01580  1.000 42.57606 ? 154 TYR B CB  1 
ATOM   3369 N N   . ASP B 1 153 ? -14.27712 0.09411   -2.50496  1.000 47.74084 ? 155 ASP B N   1 
ATOM   3370 C CA  . ASP B 1 153 ? -14.16359 1.41956   -1.89890  1.000 48.03624 ? 155 ASP B CA  1 
ATOM   3371 C C   . ASP B 1 153 ? -13.36812 1.45428   -0.58081  1.000 40.42665 ? 155 ASP B C   1 
ATOM   3372 O O   . ASP B 1 153 ? -13.37550 2.48654   0.10457   1.000 37.52290 ? 155 ASP B O   1 
ATOM   3373 C CB  . ASP B 1 153 ? -15.53823 2.06838   -1.69954  1.000 49.03890 ? 155 ASP B CB  1 
ATOM   3374 C CG  . ASP B 1 153 ? -16.38055 2.07934   -2.98811  1.000 59.29476 ? 155 ASP B CG  1 
ATOM   3375 O OD1 . ASP B 1 153 ? -16.37381 3.11530   -3.69710  1.000 58.18955 ? 155 ASP B OD1 1 
ATOM   3376 O OD2 . ASP B 1 153 ? -17.06181 1.07344   -3.28924  1.000 58.82075 ? 155 ASP B OD2 1 
ATOM   3377 N N   . CYS B 1 154 ? -12.65724 0.38846   -0.20818  1.000 35.66324 ? 156 CYS B N   1 
ATOM   3378 C CA  . CYS B 1 154 ? -11.64034 0.48598   0.84034   1.000 32.03987 ? 156 CYS B CA  1 
ATOM   3379 C C   . CYS B 1 154 ? -10.26363 0.60312   0.20175   1.000 28.49901 ? 156 CYS B C   1 
ATOM   3380 O O   . CYS B 1 154 ? -9.87222  -0.26423  -0.58658  1.000 29.91135 ? 156 CYS B O   1 
ATOM   3381 C CB  . CYS B 1 154 ? -11.65432 -0.71508  1.78446   1.000 31.28860 ? 156 CYS B CB  1 
ATOM   3382 S SG  . CYS B 1 154 ? -10.30538 -0.62595  3.03698   1.000 34.36564 ? 156 CYS B SG  1 
ATOM   3383 N N   . VAL B 1 155 ? -9.52934  1.65811   0.56485   1.000 23.89179 ? 157 VAL B N   1 
ATOM   3384 C CA  . VAL B 1 155 ? -8.17051  1.88560   0.07718   1.000 25.68747 ? 157 VAL B CA  1 
ATOM   3385 C C   . VAL B 1 155 ? -7.18880  1.18393   1.00966   1.000 23.86112 ? 157 VAL B C   1 
ATOM   3386 O O   . VAL B 1 155 ? -7.11263  1.51139   2.19518   1.000 25.71266 ? 157 VAL B O   1 
ATOM   3387 C CB  . VAL B 1 155 ? -7.85430  3.38685   -0.00584  1.000 23.78924 ? 157 VAL B CB  1 
ATOM   3388 C CG1 . VAL B 1 155 ? -6.43460  3.61231   -0.54277  1.000 22.12727 ? 157 VAL B CG1 1 
ATOM   3389 C CG2 . VAL B 1 155 ? -8.90142  4.10129   -0.87893  1.000 25.17025 ? 157 VAL B CG2 1 
ATOM   3390 N N   . SER B 1 156 ? -6.43125  0.23086   0.47601   1.000 23.41184 ? 158 SER B N   1 
ATOM   3391 C CA  . SER B 1 156 ? -5.33004  -0.41285  1.20244   1.000 27.39792 ? 158 SER B CA  1 
ATOM   3392 C C   . SER B 1 156 ? -4.02999  0.29135   0.82658   1.000 23.31118 ? 158 SER B C   1 
ATOM   3393 O O   . SER B 1 156 ? -3.48723  0.05569   -0.24854  1.000 25.27896 ? 158 SER B O   1 
ATOM   3394 C CB  . SER B 1 156 ? -5.25283  -1.90274  0.87011   1.000 28.16625 ? 158 SER B CB  1 
ATOM   3395 O OG  . SER B 1 156 ? -6.35280  -2.60669  1.42464   1.000 34.36381 ? 158 SER B OG  1 
ATOM   3396 N N   . PHE B 1 157 ? -3.53320  1.15765   1.71351   1.000 22.40304 ? 159 PHE B N   1 
ATOM   3397 C CA  . PHE B 1 157 ? -2.26116  1.84476   1.49897   1.000 22.01905 ? 159 PHE B CA  1 
ATOM   3398 C C   . PHE B 1 157 ? -1.12118  0.88029   1.80510   1.000 23.22592 ? 159 PHE B C   1 
ATOM   3399 O O   . PHE B 1 157 ? -1.07431  0.30378   2.89213   1.000 21.67517 ? 159 PHE B O   1 
ATOM   3400 C CB  . PHE B 1 157 ? -2.15513  3.07889   2.39379   1.000 24.53293 ? 159 PHE B CB  1 
ATOM   3401 C CG  . PHE B 1 157 ? -3.08747  4.18706   2.00146   1.000 21.98496 ? 159 PHE B CG  1 
ATOM   3402 C CD1 . PHE B 1 157 ? -2.82584  4.95201   0.87563   1.000 22.08635 ? 159 PHE B CD1 1 
ATOM   3403 C CD2 . PHE B 1 157 ? -4.21650  4.46968   2.76370   1.000 21.67916 ? 159 PHE B CD2 1 
ATOM   3404 C CE1 . PHE B 1 157 ? -3.68715  5.97410   0.48130   1.000 20.33388 ? 159 PHE B CE1 1 
ATOM   3405 C CE2 . PHE B 1 157 ? -5.08568  5.50162   2.37988   1.000 26.89481 ? 159 PHE B CE2 1 
ATOM   3406 C CZ  . PHE B 1 157 ? -4.80407  6.25720   1.23815   1.000 21.37193 ? 159 PHE B CZ  1 
ATOM   3407 N N   . CYS B 1 158 ? -0.21261  0.69214   0.85361   1.000 23.91735 ? 160 CYS B N   1 
ATOM   3408 C CA  . CYS B 1 158 ? 0.83873   -0.29050  1.03028   1.000 23.26312 ? 160 CYS B CA  1 
ATOM   3409 C C   . CYS B 1 158 ? 2.23688   0.27672   0.87261   1.000 26.48868 ? 160 CYS B C   1 
ATOM   3410 O O   . CYS B 1 158 ? 3.20436   -0.43197  1.18611   1.000 25.31543 ? 160 CYS B O   1 
ATOM   3411 C CB  . CYS B 1 158 ? 0.65789   -1.45678  0.03999   1.000 24.26270 ? 160 CYS B CB  1 
ATOM   3412 S SG  . CYS B 1 158 ? 0.71761   -1.00242  -1.70679  1.000 26.60222 ? 160 CYS B SG  1 
ATOM   3413 N N   . TYR B 1 159 ? 2.38226   1.52364   0.42551   1.000 20.60358 ? 161 TYR B N   1 
ATOM   3414 C CA  . TYR B 1 159 ? 3.71264   2.00069   0.07454   1.000 24.65968 ? 161 TYR B CA  1 
ATOM   3415 C C   . TYR B 1 159 ? 3.78985   3.51439   0.22203   1.000 24.35658 ? 161 TYR B C   1 
ATOM   3416 O O   . TYR B 1 159 ? 2.82477   4.22910   -0.05920  1.000 23.39977 ? 161 TYR B O   1 
ATOM   3417 C CB  . TYR B 1 159 ? 4.05851   1.57981   -1.35989  1.000 24.72073 ? 161 TYR B CB  1 
ATOM   3418 C CG  . TYR B 1 159 ? 5.40659   2.05130   -1.83604  1.000 23.47002 ? 161 TYR B CG  1 
ATOM   3419 C CD1 . TYR B 1 159 ? 6.55600   1.34761   -1.50782  1.000 26.72124 ? 161 TYR B CD1 1 
ATOM   3420 C CD2 . TYR B 1 159 ? 5.53257   3.19855   -2.61501  1.000 29.45977 ? 161 TYR B CD2 1 
ATOM   3421 C CE1 . TYR B 1 159 ? 7.81232   1.77427   -1.94483  1.000 26.86424 ? 161 TYR B CE1 1 
ATOM   3422 C CE2 . TYR B 1 159 ? 6.79094   3.63939   -3.05522  1.000 27.26207 ? 161 TYR B CE2 1 
ATOM   3423 C CZ  . TYR B 1 159 ? 7.91357   2.92258   -2.71412  1.000 26.97483 ? 161 TYR B CZ  1 
ATOM   3424 O OH  . TYR B 1 159 ? 9.16914   3.32696   -3.14071  1.000 33.36675 ? 161 TYR B OH  1 
ATOM   3425 N N   . MET B 1 160 ? 4.95747   4.00356   0.64552   1.000 24.12492 ? 162 MET B N   1 
ATOM   3426 C CA  . MET B 1 160 ? 5.26669   5.42695   0.55348   1.000 23.24457 ? 162 MET B CA  1 
ATOM   3427 C C   . MET B 1 160 ? 6.69832   5.58774   0.06687   1.000 24.20897 ? 162 MET B C   1 
ATOM   3428 O O   . MET B 1 160 ? 7.60824   4.92959   0.57983   1.000 22.63064 ? 162 MET B O   1 
ATOM   3429 C CB  . MET B 1 160 ? 5.08040   6.14462   1.90054   1.000 22.83879 ? 162 MET B CB  1 
ATOM   3430 C CG  . MET B 1 160 ? 5.59127   7.59186   1.92635   1.000 25.46583 ? 162 MET B CG  1 
ATOM   3431 S SD  . MET B 1 160 ? 5.20347   8.45887   3.47474   1.000 30.75893 ? 162 MET B SD  1 
ATOM   3432 C CE  . MET B 1 160 ? 3.54082   9.04735   3.05773   1.000 25.50384 ? 162 MET B CE  1 
ATOM   3433 N N   . ALA B 1 161 ? 6.89443   6.47190   -0.90657  1.000 24.74540 ? 163 ALA B N   1 
ATOM   3434 C CA  . ALA B 1 161 ? 8.21398   6.66772   -1.49465  1.000 29.28660 ? 163 ALA B CA  1 
ATOM   3435 C C   . ALA B 1 161 ? 9.10156   7.48819   -0.56122  1.000 25.48327 ? 163 ALA B C   1 
ATOM   3436 O O   . ALA B 1 161 ? 8.69579   8.55413   -0.08807  1.000 27.05171 ? 163 ALA B O   1 
ATOM   3437 C CB  . ALA B 1 161 ? 8.08037   7.35712   -2.85412  1.000 25.95660 ? 163 ALA B CB  1 
ATOM   3438 N N   . HIS B 1 162 ? 10.32189  7.00069   -0.30667  1.000 26.72539 ? 164 HIS B N   1 
ATOM   3439 C CA  . HIS B 1 162 ? 11.28230  7.75998   0.49264   1.000 25.99309 ? 164 HIS B CA  1 
ATOM   3440 C C   . HIS B 1 162 ? 12.49336  8.24408   -0.29005  1.000 26.38386 ? 164 HIS B C   1 
ATOM   3441 O O   . HIS B 1 162 ? 13.09113  9.24989   0.09229   1.000 33.38789 ? 164 HIS B O   1 
ATOM   3442 C CB  . HIS B 1 162 ? 11.78643  6.92424   1.67741   1.000 25.17409 ? 164 HIS B CB  1 
ATOM   3443 C CG  . HIS B 1 162 ? 10.79275  6.79074   2.78593   1.000 26.44636 ? 164 HIS B CG  1 
ATOM   3444 N ND1 . HIS B 1 162 ? 11.05760  7.18023   4.08486   1.000 22.79033 ? 164 HIS B ND1 1 
ATOM   3445 C CD2 . HIS B 1 162 ? 9.52903   6.30153   2.78912   1.000 22.92099 ? 164 HIS B CD2 1 
ATOM   3446 C CE1 . HIS B 1 162 ? 9.99978   6.93823   4.83686   1.000 24.45654 ? 164 HIS B CE1 1 
ATOM   3447 N NE2 . HIS B 1 162 ? 9.05890   6.40403   4.07476   1.000 24.31892 ? 164 HIS B NE2 1 
ATOM   3448 N N   . MET B 1 163 ? 12.86576  7.56252   -1.36762  1.000 27.17147 ? 165 MET B N   1 
ATOM   3449 C CA  . MET B 1 163 ? 14.17436  7.75273   -1.98663  1.000 35.69969 ? 165 MET B CA  1 
ATOM   3450 C C   . MET B 1 163 ? 14.12348  7.38086   -3.46310  1.000 32.45095 ? 165 MET B C   1 
ATOM   3451 O O   . MET B 1 163 ? 13.36509  6.50110   -3.86479  1.000 30.80158 ? 165 MET B O   1 
ATOM   3452 C CB  . MET B 1 163 ? 15.24328  6.86556   -1.33356  1.000 29.27057 ? 165 MET B CB  1 
ATOM   3453 C CG  . MET B 1 163 ? 15.85626  7.31156   -0.02974  1.000 46.77107 ? 165 MET B CG  1 
ATOM   3454 S SD  . MET B 1 163 ? 16.23238  5.77110   0.84027   1.000 54.85420 ? 165 MET B SD  1 
ATOM   3455 C CE  . MET B 1 163 ? 16.93286  4.88000   -0.52697  1.000 23.59891 ? 165 MET B CE  1 
ATOM   3456 N N   . GLU B 1 164 ? 14.98205  8.01459   -4.25775  1.000 36.09678 ? 166 GLU B N   1 
ATOM   3457 C CA  . GLU B 1 164 ? 15.29960  7.55425   -5.60759  1.000 40.98389 ? 166 GLU B CA  1 
ATOM   3458 C C   . GLU B 1 164 ? 16.68409  6.91416   -5.57575  1.000 46.63354 ? 166 GLU B C   1 
ATOM   3459 O O   . GLU B 1 164 ? 17.64396  7.52957   -5.10071  1.000 44.87849 ? 166 GLU B O   1 
ATOM   3460 C CB  . GLU B 1 164 ? 15.25882  8.70402   -6.61691  1.000 47.21987 ? 166 GLU B CB  1 
ATOM   3461 N N   . LEU B 1 165 ? 16.77905  5.67399   -6.04306  1.000 40.70779 ? 167 LEU B N   1 
ATOM   3462 C CA  . LEU B 1 165 ? 18.05055  4.98234   -6.13044  1.000 40.08508 ? 167 LEU B CA  1 
ATOM   3463 C C   . LEU B 1 165 ? 18.75032  5.36307   -7.43291  1.000 48.02230 ? 167 LEU B C   1 
ATOM   3464 O O   . LEU B 1 165 ? 18.09698  5.78266   -8.39209  1.000 45.48358 ? 167 LEU B O   1 
ATOM   3465 C CB  . LEU B 1 165 ? 17.83558  3.47342   -6.05302  1.000 43.29609 ? 167 LEU B CB  1 
ATOM   3466 C CG  . LEU B 1 165 ? 17.37447  2.93572   -4.69652  1.000 38.97771 ? 167 LEU B CG  1 
ATOM   3467 C CD1 . LEU B 1 165 ? 17.19779  1.42400   -4.74244  1.000 38.40433 ? 167 LEU B CD1 1 
ATOM   3468 C CD2 . LEU B 1 165 ? 18.36016  3.32950   -3.61198  1.000 40.39094 ? 167 LEU B CD2 1 
ATOM   3469 N N   . PRO B 1 166 ? 20.08320  5.22708   -7.49614  1.000 45.79836 ? 168 PRO B N   1 
ATOM   3470 C CA  . PRO B 1 166 ? 20.81639  5.76929   -8.65656  1.000 48.23776 ? 168 PRO B CA  1 
ATOM   3471 C C   . PRO B 1 166 ? 20.31426  5.27873   -10.00662 1.000 50.30893 ? 168 PRO B C   1 
ATOM   3472 O O   . PRO B 1 166 ? 20.52182  5.96613   -11.01474 1.000 54.68534 ? 168 PRO B O   1 
ATOM   3473 C CB  . PRO B 1 166 ? 22.26937  5.33111   -8.39614  1.000 49.37325 ? 168 PRO B CB  1 
ATOM   3474 C CG  . PRO B 1 166 ? 22.20457  4.30024   -7.32049  1.000 49.62516 ? 168 PRO B CG  1 
ATOM   3475 C CD  . PRO B 1 166 ? 20.99876  4.64625   -6.49983  1.000 48.93621 ? 168 PRO B CD  1 
ATOM   3476 N N   . THR B 1 167 ? 19.63572  4.13443   -10.06588 1.000 48.67804 ? 169 THR B N   1 
ATOM   3477 C CA  . THR B 1 167 ? 19.14978  3.62364   -11.34142 1.000 44.35283 ? 169 THR B CA  1 
ATOM   3478 C C   . THR B 1 167 ? 17.76858  4.16076   -11.71834 1.000 51.63243 ? 169 THR B C   1 
ATOM   3479 O O   . THR B 1 167 ? 17.20370  3.72437   -12.72862 1.000 50.26944 ? 169 THR B O   1 
ATOM   3480 C CB  . THR B 1 167 ? 19.13313  2.09332   -11.31853 1.000 45.95399 ? 169 THR B CB  1 
ATOM   3481 O OG1 . THR B 1 167 ? 18.50124  1.62654   -10.11560 1.000 50.01519 ? 169 THR B OG1 1 
ATOM   3482 C CG2 . THR B 1 167 ? 20.54683  1.55282   -11.37973 1.000 46.07988 ? 169 THR B CG2 1 
ATOM   3483 N N   . GLY B 1 168 ? 17.21378  5.09802   -10.94617 1.000 49.95431 ? 170 GLY B N   1 
ATOM   3484 C CA  . GLY B 1 168 ? 15.91972  5.68904   -11.22530 1.000 51.67815 ? 170 GLY B CA  1 
ATOM   3485 C C   . GLY B 1 168 ? 14.77006  5.07936   -10.44220 1.000 47.96200 ? 170 GLY B C   1 
ATOM   3486 O O   . GLY B 1 168 ? 13.78284  5.77085   -10.16976 1.000 53.19049 ? 170 GLY B O   1 
ATOM   3487 N N   . VAL B 1 169 ? 14.87508  3.79964   -10.07747 1.000 43.75379 ? 171 VAL B N   1 
ATOM   3488 C CA  . VAL B 1 169 ? 13.84273  3.17196   -9.26730  1.000 40.58932 ? 171 VAL B CA  1 
ATOM   3489 C C   . VAL B 1 169 ? 13.76131  3.87231   -7.91142  1.000 43.09926 ? 171 VAL B C   1 
ATOM   3490 O O   . VAL B 1 169 ? 14.72116  4.50271   -7.44660  1.000 40.28736 ? 171 VAL B O   1 
ATOM   3491 C CB  . VAL B 1 169 ? 14.14043  1.67397   -9.10269  1.000 39.34316 ? 171 VAL B CB  1 
ATOM   3492 C CG1 . VAL B 1 169 ? 14.21165  1.00481   -10.46514 1.000 38.77979 ? 171 VAL B CG1 1 
ATOM   3493 C CG2 . VAL B 1 169 ? 15.45165  1.47086   -8.33155  1.000 37.87917 ? 171 VAL B CG2 1 
ATOM   3494 N N   . HIS B 1 170 ? 12.59846  3.77803   -7.27189  1.000 35.90627 ? 172 HIS B N   1 
ATOM   3495 C CA  . HIS B 1 170 ? 12.51508  4.33416   -5.93364  1.000 36.13575 ? 172 HIS B CA  1 
ATOM   3496 C C   . HIS B 1 170 ? 12.39261  3.23129   -4.88740  1.000 31.98365 ? 172 HIS B C   1 
ATOM   3497 O O   . HIS B 1 170 ? 12.11533  2.06783   -5.18802  1.000 34.06618 ? 172 HIS B O   1 
ATOM   3498 C CB  . HIS B 1 170 ? 11.39815  5.39638   -5.78709  1.000 36.46472 ? 172 HIS B CB  1 
ATOM   3499 C CG  . HIS B 1 170 ? 10.06537  5.04036   -6.36408  1.000 42.51313 ? 172 HIS B CG  1 
ATOM   3500 N ND1 . HIS B 1 170 ? 9.02449   4.56213   -5.59049  1.000 42.54089 ? 172 HIS B ND1 1 
ATOM   3501 C CD2 . HIS B 1 170 ? 9.55957   5.21205   -7.60959  1.000 43.57823 ? 172 HIS B CD2 1 
ATOM   3502 C CE1 . HIS B 1 170 ? 7.95571   4.39445   -6.35008  1.000 40.81292 ? 172 HIS B CE1 1 
ATOM   3503 N NE2 . HIS B 1 170 ? 8.25384   4.78118   -7.57965  1.000 48.01386 ? 172 HIS B NE2 1 
ATOM   3504 N N   . ALA B 1 171 ? 12.72219  3.60846   -3.65694  1.000 28.94257 ? 173 ALA B N   1 
ATOM   3505 C CA  . ALA B 1 171 ? 12.63839  2.74549   -2.49524  1.000 25.39290 ? 173 ALA B CA  1 
ATOM   3506 C C   . ALA B 1 171 ? 11.81514  3.46489   -1.43390  1.000 23.81929 ? 173 ALA B C   1 
ATOM   3507 O O   . ALA B 1 171 ? 11.73042  4.69689   -1.42561  1.000 26.67595 ? 173 ALA B O   1 
ATOM   3508 C CB  . ALA B 1 171 ? 14.02870  2.39084   -1.94217  1.000 30.52355 ? 173 ALA B CB  1 
ATOM   3509 N N   . GLY B 1 172 ? 11.19494  2.69032   -0.55535  1.000 26.84564 ? 174 GLY B N   1 
ATOM   3510 C CA  . GLY B 1 172 ? 10.31079  3.28482   0.43131   1.000 25.01505 ? 174 GLY B CA  1 
ATOM   3511 C C   . GLY B 1 172 ? 9.82156   2.25267   1.41867   1.000 23.03103 ? 174 GLY B C   1 
ATOM   3512 O O   . GLY B 1 172 ? 10.34994  1.14168   1.50615   1.000 23.80575 ? 174 GLY B O   1 
ATOM   3513 N N   . THR B 1 173 ? 8.79550   2.64401   2.16650   1.000 22.77528 ? 175 THR B N   1 
ATOM   3514 C CA  . THR B 1 173 ? 8.32108   1.90686   3.32507   1.000 22.03536 ? 175 THR B CA  1 
ATOM   3515 C C   . THR B 1 173 ? 6.84080   1.58492   3.16425   1.000 22.88087 ? 175 THR B C   1 
ATOM   3516 O O   . THR B 1 173 ? 6.16719   2.08265   2.25899   1.000 22.59527 ? 175 THR B O   1 
ATOM   3517 C CB  . THR B 1 173 ? 8.51959   2.70478   4.62665   1.000 23.49058 ? 175 THR B CB  1 
ATOM   3518 O OG1 . THR B 1 173 ? 7.64772   3.83658   4.63928   1.000 22.77906 ? 175 THR B OG1 1 
ATOM   3519 C CG2 . THR B 1 173 ? 9.98745   3.18168   4.78291   1.000 22.22283 ? 175 THR B CG2 1 
ATOM   3520 N N   . ASP B 1 174 ? 6.33211   0.74454   4.05715   1.000 23.12690 ? 176 ASP B N   1 
ATOM   3521 C CA  . ASP B 1 174 ? 4.88637   0.68183   4.21084   1.000 23.00553 ? 176 ASP B CA  1 
ATOM   3522 C C   . ASP B 1 174 ? 4.43294   1.91564   5.00313   1.000 22.33002 ? 176 ASP B C   1 
ATOM   3523 O O   . ASP B 1 174 ? 5.22633   2.80708   5.32406   1.000 23.38351 ? 176 ASP B O   1 
ATOM   3524 C CB  . ASP B 1 174 ? 4.46288   -0.65703  4.83185   1.000 21.77209 ? 176 ASP B CB  1 
ATOM   3525 C CG  . ASP B 1 174 ? 5.08972   -0.93452  6.20342   1.000 23.36753 ? 176 ASP B CG  1 
ATOM   3526 O OD1 . ASP B 1 174 ? 5.37011   0.01473   6.94981   1.000 23.38374 ? 176 ASP B OD1 1 
ATOM   3527 O OD2 . ASP B 1 174 ? 5.28500   -2.12970  6.55025   1.000 24.32566 ? 176 ASP B OD2 1 
ATOM   3528 N N   . LEU B 1 175 ? 3.14444   2.00847   5.29994   1.000 21.45192 ? 177 LEU B N   1 
ATOM   3529 C CA  . LEU B 1 175 ? 2.66291   3.20713   5.98279   1.000 23.42249 ? 177 LEU B CA  1 
ATOM   3530 C C   . LEU B 1 175 ? 2.90502   3.16111   7.48678   1.000 23.13029 ? 177 LEU B C   1 
ATOM   3531 O O   . LEU B 1 175 ? 2.69187   4.17318   8.16209   1.000 25.51864 ? 177 LEU B O   1 
ATOM   3532 C CB  . LEU B 1 175 ? 1.17011   3.44044   5.69970   1.000 23.31142 ? 177 LEU B CB  1 
ATOM   3533 C CG  . LEU B 1 175 ? 0.86963   4.39399   4.52803   1.000 24.91372 ? 177 LEU B CG  1 
ATOM   3534 C CD1 . LEU B 1 175 ? 1.29103   5.82727   4.86020   1.000 24.49272 ? 177 LEU B CD1 1 
ATOM   3535 C CD2 . LEU B 1 175 ? 1.55194   3.95145   3.23214   1.000 22.97762 ? 177 LEU B CD2 1 
ATOM   3536 N N   . GLU B 1 176 ? 3.34511   2.02435   8.02026   1.000 23.45185 ? 178 GLU B N   1 
ATOM   3537 C CA  . GLU B 1 176 ? 3.85834   1.94823   9.37841   1.000 24.93873 ? 178 GLU B CA  1 
ATOM   3538 C C   . GLU B 1 176 ? 5.35815   2.25161   9.46032   1.000 27.15059 ? 178 GLU B C   1 
ATOM   3539 O O   . GLU B 1 176 ? 5.95173   2.08468   10.52860  1.000 25.65882 ? 178 GLU B O   1 
ATOM   3540 C CB  . GLU B 1 176 ? 3.55009   0.57115   9.96729   1.000 25.78058 ? 178 GLU B CB  1 
ATOM   3541 C CG  . GLU B 1 176 ? 2.04564   0.36827   10.20774  1.000 34.30700 ? 178 GLU B CG  1 
ATOM   3542 C CD  . GLU B 1 176 ? 1.69707   -1.06079  10.57212  1.000 39.14621 ? 178 GLU B CD  1 
ATOM   3543 O OE1 . GLU B 1 176 ? 1.17253   -1.78359  9.69715   1.000 50.15421 ? 178 GLU B OE1 1 
ATOM   3544 O OE2 . GLU B 1 176 ? 1.95685   -1.46823  11.72192  1.000 41.77812 ? 178 GLU B OE2 1 
ATOM   3545 N N   . GLY B 1 177 ? 5.97683   2.69737   8.36203   1.000 24.30104 ? 179 GLY B N   1 
ATOM   3546 C CA  . GLY B 1 177 ? 7.36238   3.13877   8.38531   1.000 25.01811 ? 179 GLY B CA  1 
ATOM   3547 C C   . GLY B 1 177 ? 8.40849   2.05275   8.25783   1.000 26.16681 ? 179 GLY B C   1 
ATOM   3548 O O   . GLY B 1 177 ? 9.60005   2.33139   8.47399   1.000 24.46421 ? 179 GLY B O   1 
ATOM   3549 N N   . ASN B 1 178 ? 8.01873   0.82971   7.90112   1.000 23.19162 ? 180 ASN B N   1 
ATOM   3550 C CA  . ASN B 1 178 ? 8.97233   -0.26346  7.73513   1.000 24.61105 ? 180 ASN B CA  1 
ATOM   3551 C C   . ASN B 1 178 ? 9.45603   -0.30111  6.29306   1.000 24.49427 ? 180 ASN B C   1 
ATOM   3552 O O   . ASN B 1 178 ? 8.63987   -0.41075  5.37055   1.000 25.67957 ? 180 ASN B O   1 
ATOM   3553 C CB  . ASN B 1 178 ? 8.31829   -1.58730  8.11240   1.000 25.74820 ? 180 ASN B CB  1 
ATOM   3554 C CG  . ASN B 1 178 ? 7.73137   -1.55711  9.50435   1.000 28.29070 ? 180 ASN B CG  1 
ATOM   3555 O OD1 . ASN B 1 178 ? 8.47168   -1.54996  10.49351  1.000 25.88740 ? 180 ASN B OD1 1 
ATOM   3556 N ND2 . ASN B 1 178 ? 6.40191   -1.53899  9.59544   1.000 28.21032 ? 180 ASN B ND2 1 
ATOM   3557 N N   . PHE B 1 179 ? 10.77485  -0.22518  6.09328   1.000 23.62431 ? 181 PHE B N   1 
ATOM   3558 C CA  . PHE B 1 179 ? 11.30314  -0.24069  4.73473   1.000 22.50342 ? 181 PHE B CA  1 
ATOM   3559 C C   . PHE B 1 179 ? 10.98724  -1.55133  4.02423   1.000 19.45777 ? 181 PHE B C   1 
ATOM   3560 O O   . PHE B 1 179 ? 10.95411  -2.63313  4.61847   1.000 21.12778 ? 181 PHE B O   1 
ATOM   3561 C CB  . PHE B 1 179 ? 12.83155  -0.01370  4.71106   1.000 22.86606 ? 181 PHE B CB  1 
ATOM   3562 C CG  . PHE B 1 179 ? 13.20640  1.38502   4.33279   1.000 23.84080 ? 181 PHE B CG  1 
ATOM   3563 C CD1 . PHE B 1 179 ? 13.24632  1.76818   2.99931   1.000 24.43750 ? 181 PHE B CD1 1 
ATOM   3564 C CD2 . PHE B 1 179 ? 13.46707  2.33191   5.31409   1.000 24.26744 ? 181 PHE B CD2 1 
ATOM   3565 C CE1 . PHE B 1 179 ? 13.54852  3.07407   2.64013   1.000 26.99162 ? 181 PHE B CE1 1 
ATOM   3566 C CE2 . PHE B 1 179 ? 13.77070  3.63580   4.97218   1.000 27.73417 ? 181 PHE B CE2 1 
ATOM   3567 C CZ  . PHE B 1 179 ? 13.81362  4.01104   3.62028   1.000 30.36058 ? 181 PHE B CZ  1 
ATOM   3568 N N   . TYR B 1 180 ? 10.77740  -1.43494  2.72308   1.000 20.36110 ? 182 TYR B N   1 
ATOM   3569 C CA  . TYR B 1 180 ? 10.84746  -2.56268  1.82213   1.000 20.08960 ? 182 TYR B CA  1 
ATOM   3570 C C   . TYR B 1 180 ? 12.28310  -2.62035  1.31296   1.000 21.31586 ? 182 TYR B C   1 
ATOM   3571 O O   . TYR B 1 180 ? 12.78332  -1.63904  0.75854   1.000 23.21721 ? 182 TYR B O   1 
ATOM   3572 C CB  . TYR B 1 180 ? 9.89137   -2.39689  0.64845   1.000 22.20182 ? 182 TYR B CB  1 
ATOM   3573 C CG  . TYR B 1 180 ? 8.41509   -2.47780  0.97594   1.000 21.51934 ? 182 TYR B CG  1 
ATOM   3574 C CD1 . TYR B 1 180 ? 7.79407   -3.70668  1.18678   1.000 22.66470 ? 182 TYR B CD1 1 
ATOM   3575 C CD2 . TYR B 1 180 ? 7.63442   -1.31804  1.03548   1.000 23.98093 ? 182 TYR B CD2 1 
ATOM   3576 C CE1 . TYR B 1 180 ? 6.38964   -3.78032  1.45384   1.000 24.20332 ? 182 TYR B CE1 1 
ATOM   3577 C CE2 . TYR B 1 180 ? 6.25375   -1.38212  1.30026   1.000 22.56782 ? 182 TYR B CE2 1 
ATOM   3578 C CZ  . TYR B 1 180 ? 5.65126   -2.61232  1.51206   1.000 24.25914 ? 182 TYR B CZ  1 
ATOM   3579 O OH  . TYR B 1 180 ? 4.29216   -2.68065  1.76956   1.000 27.11796 ? 182 TYR B OH  1 
ATOM   3580 N N   . GLY B 1 181 ? 12.92915  -3.75447  1.49406   1.000 23.80912 ? 183 GLY B N   1 
ATOM   3581 C CA  . GLY B 1 181 ? 14.28016  -3.91686  1.01066   1.000 25.39725 ? 183 GLY B CA  1 
ATOM   3582 C C   . GLY B 1 181 ? 15.33083  -3.36099  1.94638   1.000 26.32754 ? 183 GLY B C   1 
ATOM   3583 O O   . GLY B 1 181 ? 15.04935  -2.60456  2.88380   1.000 24.46363 ? 183 GLY B O   1 
ATOM   3584 N N   . PRO B 1 182 ? 16.57618  -3.72367  1.69165   1.000 24.21570 ? 184 PRO B N   1 
ATOM   3585 C CA  . PRO B 1 182 ? 17.67533  -3.37078  2.61186   1.000 25.97708 ? 184 PRO B CA  1 
ATOM   3586 C C   . PRO B 1 182 ? 18.18473  -1.94581  2.41683   1.000 31.68897 ? 184 PRO B C   1 
ATOM   3587 O O   . PRO B 1 182 ? 19.35468  -1.71417  2.10849   1.000 33.15950 ? 184 PRO B O   1 
ATOM   3588 C CB  . PRO B 1 182 ? 18.73654  -4.42770  2.26657   1.000 25.48311 ? 184 PRO B CB  1 
ATOM   3589 C CG  . PRO B 1 182 ? 18.53861  -4.68464  0.78218   1.000 27.65356 ? 184 PRO B CG  1 
ATOM   3590 C CD  . PRO B 1 182 ? 16.99826  -4.64184  0.62025   1.000 27.46825 ? 184 PRO B CD  1 
ATOM   3591 N N   . PHE B 1 183 ? 17.29699  -0.96987  2.59522   1.000 26.72635 ? 185 PHE B N   1 
ATOM   3592 C CA  . PHE B 1 183 ? 17.60762  0.43746   2.38183   1.000 28.90583 ? 185 PHE B CA  1 
ATOM   3593 C C   . PHE B 1 183 ? 17.37933  1.22865   3.66074   1.000 28.99847 ? 185 PHE B C   1 
ATOM   3594 O O   . PHE B 1 183 ? 16.55714  0.85640   4.50247   1.000 29.72610 ? 185 PHE B O   1 
ATOM   3595 C CB  . PHE B 1 183 ? 16.75664  1.02004   1.24068   1.000 28.23702 ? 185 PHE B CB  1 
ATOM   3596 C CG  . PHE B 1 183 ? 16.85502  0.22609   -0.02913  1.000 28.43393 ? 185 PHE B CG  1 
ATOM   3597 C CD1 . PHE B 1 183 ? 18.04174  0.20914   -0.75212  1.000 29.69970 ? 185 PHE B CD1 1 
ATOM   3598 C CD2 . PHE B 1 183 ? 15.78108  -0.52601  -0.48379  1.000 26.59097 ? 185 PHE B CD2 1 
ATOM   3599 C CE1 . PHE B 1 183 ? 18.15921  -0.54374  -1.90321  1.000 33.41884 ? 185 PHE B CE1 1 
ATOM   3600 C CE2 . PHE B 1 183 ? 15.87491  -1.26760  -1.64887  1.000 32.19225 ? 185 PHE B CE2 1 
ATOM   3601 C CZ  . PHE B 1 183 ? 17.07286  -1.27807  -2.36421  1.000 35.43835 ? 185 PHE B CZ  1 
ATOM   3602 N N   . VAL B 1 184 ? 18.11314  2.32866   3.80725   1.000 29.35198 ? 186 VAL B N   1 
ATOM   3603 C CA  . VAL B 1 184 ? 18.01688  3.13943   5.01107   1.000 29.25406 ? 186 VAL B CA  1 
ATOM   3604 C C   . VAL B 1 184 ? 17.82577  4.59084   4.61201   1.000 28.37653 ? 186 VAL B C   1 
ATOM   3605 O O   . VAL B 1 184 ? 18.23651  5.01346   3.52624   1.000 31.42418 ? 186 VAL B O   1 
ATOM   3606 C CB  . VAL B 1 184 ? 19.26271  2.97952   5.91276   1.000 30.99747 ? 186 VAL B CB  1 
ATOM   3607 C CG1 . VAL B 1 184 ? 19.30602  1.57308   6.49625   1.000 30.49123 ? 186 VAL B CG1 1 
ATOM   3608 C CG2 . VAL B 1 184 ? 20.52489  3.28008   5.11215   1.000 30.96988 ? 186 VAL B CG2 1 
ATOM   3609 N N   . ASP B 1 185 ? 17.19892  5.36096   5.50719   1.000 28.76868 ? 187 ASP B N   1 
ATOM   3610 C CA  . ASP B 1 185 ? 16.96238  6.78267   5.25263   1.000 31.42660 ? 187 ASP B CA  1 
ATOM   3611 C C   . ASP B 1 185 ? 18.09728  7.61443   5.85926   1.000 36.96138 ? 187 ASP B C   1 
ATOM   3612 O O   . ASP B 1 185 ? 17.92449  8.45070   6.74821   1.000 32.45573 ? 187 ASP B O   1 
ATOM   3613 C CB  . ASP B 1 185 ? 15.57474  7.20953   5.74941   1.000 27.85578 ? 187 ASP B CB  1 
ATOM   3614 C CG  . ASP B 1 185 ? 15.30536  6.88207   7.22414   1.000 29.71363 ? 187 ASP B CG  1 
ATOM   3615 O OD1 . ASP B 1 185 ? 16.10043  6.19666   7.91232   1.000 30.31396 ? 187 ASP B OD1 1 
ATOM   3616 O OD2 . ASP B 1 185 ? 14.24050  7.33112   7.69930   1.000 27.74673 ? 187 ASP B OD2 1 
ATOM   3617 N N   . ARG B 1 186 ? 19.29399  7.32505   5.34266   1.000 34.59734 ? 188 ARG B N   1 
ATOM   3618 C CA  . ARG B 1 186 ? 20.52528  8.04100   5.63633   1.000 44.33834 ? 188 ARG B CA  1 
ATOM   3619 C C   . ARG B 1 186 ? 21.22719  8.29241   4.30893   1.000 46.07850 ? 188 ARG B C   1 
ATOM   3620 O O   . ARG B 1 186 ? 21.06235  7.52520   3.35625   1.000 40.76570 ? 188 ARG B O   1 
ATOM   3621 C CB  . ARG B 1 186 ? 21.43718  7.23114   6.57844   1.000 43.21221 ? 188 ARG B CB  1 
ATOM   3622 C CG  . ARG B 1 186 ? 20.83274  6.91733   7.94952   1.000 48.08906 ? 188 ARG B CG  1 
ATOM   3623 C CD  . ARG B 1 186 ? 21.33018  5.58193   8.50454   1.000 46.27196 ? 188 ARG B CD  1 
ATOM   3624 N NE  . ARG B 1 186 ? 22.68259  5.68005   9.05067   1.000 52.07907 ? 188 ARG B NE  1 
ATOM   3625 C CZ  . ARG B 1 186 ? 22.97472  6.14836   10.26460  1.000 52.94731 ? 188 ARG B CZ  1 
ATOM   3626 N NH1 . ARG B 1 186 ? 22.00615  6.56642   11.07264  1.000 48.80343 ? 188 ARG B NH1 1 
ATOM   3627 N NH2 . ARG B 1 186 ? 24.24075  6.19648   10.67174  1.000 53.42865 ? 188 ARG B NH2 1 
ATOM   3628 N N   . GLN B 1 187 ? 21.99206  9.37988   4.23374   1.000 47.44098 ? 189 GLN B N   1 
ATOM   3629 C CA  . GLN B 1 187 ? 22.77422  9.66570   3.02973   1.000 48.38175 ? 189 GLN B CA  1 
ATOM   3630 C C   . GLN B 1 187 ? 23.97392  8.72748   3.02387   1.000 48.96024 ? 189 GLN B C   1 
ATOM   3631 O O   . GLN B 1 187 ? 24.95346  8.94149   3.74305   1.000 52.19883 ? 189 GLN B O   1 
ATOM   3632 C CB  . GLN B 1 187 ? 23.20461  11.12837  2.98950   1.000 52.16555 ? 189 GLN B CB  1 
ATOM   3633 N N   . THR B 1 188 ? 23.87805  7.65166   2.24773   1.000 45.63006 ? 190 THR B N   1 
ATOM   3634 C CA  . THR B 1 188 ? 24.94102  6.66239   2.14681   1.000 42.77085 ? 190 THR B CA  1 
ATOM   3635 C C   . THR B 1 188 ? 24.81693  5.98238   0.79297   1.000 44.30599 ? 190 THR B C   1 
ATOM   3636 O O   . THR B 1 188 ? 23.82194  6.14732   0.08429   1.000 45.97249 ? 190 THR B O   1 
ATOM   3637 C CB  . THR B 1 188 ? 24.88136  5.64163   3.29641   1.000 48.15323 ? 190 THR B CB  1 
ATOM   3638 O OG1 . THR B 1 188 ? 26.05505  4.81533   3.28062   1.000 47.37098 ? 190 THR B OG1 1 
ATOM   3639 C CG2 . THR B 1 188 ? 23.63977  4.75623   3.17997   1.000 45.52257 ? 190 THR B CG2 1 
ATOM   3640 N N   . ALA B 1 189 ? 25.84281  5.21664   0.43079   1.000 44.87811 ? 191 ALA B N   1 
ATOM   3641 C CA  . ALA B 1 189 ? 25.86219  4.53341   -0.85908  1.000 41.53064 ? 191 ALA B CA  1 
ATOM   3642 C C   . ALA B 1 189 ? 24.92801  3.32853   -0.79966  1.000 40.12319 ? 191 ALA B C   1 
ATOM   3643 O O   . ALA B 1 189 ? 25.16604  2.37450   -0.05159  1.000 42.35322 ? 191 ALA B O   1 
ATOM   3644 C CB  . ALA B 1 189 ? 27.28217  4.11653   -1.23178  1.000 45.87630 ? 191 ALA B CB  1 
ATOM   3645 N N   . GLN B 1 190 ? 23.84635  3.38038   -1.56818  1.000 39.36462 ? 192 GLN B N   1 
ATOM   3646 C CA  . GLN B 1 190 ? 22.89715  2.28046   -1.63316  1.000 39.69301 ? 192 GLN B CA  1 
ATOM   3647 C C   . GLN B 1 190 ? 22.51901  2.05843   -3.08511  1.000 39.57118 ? 192 GLN B C   1 
ATOM   3648 O O   . GLN B 1 190 ? 22.46369  3.00304   -3.87577  1.000 39.88518 ? 192 GLN B O   1 
ATOM   3649 C CB  . GLN B 1 190 ? 21.63176  2.55127   -0.81714  1.000 38.24174 ? 192 GLN B CB  1 
ATOM   3650 C CG  . GLN B 1 190 ? 21.79063  3.58005   0.26453   1.000 37.14887 ? 192 GLN B CG  1 
ATOM   3651 C CD  . GLN B 1 190 ? 20.59552  3.60093   1.18506   1.000 34.95136 ? 192 GLN B CD  1 
ATOM   3652 O OE1 . GLN B 1 190 ? 20.09692  2.54834   1.58203   1.000 30.52140 ? 192 GLN B OE1 1 
ATOM   3653 N NE2 . GLN B 1 190 ? 20.12408  4.79659   1.52532   1.000 31.84112 ? 192 GLN B NE2 1 
ATOM   3654 N N   . ALA B 1 191 ? 22.24287  0.80367   -3.42299  1.000 40.72438 ? 193 ALA B N   1 
ATOM   3655 C CA  . ALA B 1 191 ? 21.97292  0.44762   -4.80398  1.000 43.42691 ? 193 ALA B CA  1 
ATOM   3656 C C   . ALA B 1 191 ? 21.01654  -0.73337  -4.84481  1.000 35.82704 ? 193 ALA B C   1 
ATOM   3657 O O   . ALA B 1 191 ? 21.06480  -1.62364  -3.99262  1.000 36.89451 ? 193 ALA B O   1 
ATOM   3658 C CB  . ALA B 1 191 ? 23.27603  0.12224   -5.55371  1.000 35.94784 ? 193 ALA B CB  1 
ATOM   3659 N N   . ALA B 1 192 ? 20.14397  -0.72805  -5.84809  1.000 39.32603 ? 194 ALA B N   1 
ATOM   3660 C CA  . ALA B 1 192 ? 19.25498  -1.85967  -6.06688  1.000 37.50680 ? 194 ALA B CA  1 
ATOM   3661 C C   . ALA B 1 192 ? 20.06306  -3.11897  -6.36847  1.000 39.93240 ? 194 ALA B C   1 
ATOM   3662 O O   . ALA B 1 192 ? 20.98612  -3.09662  -7.18673  1.000 38.36065 ? 194 ALA B O   1 
ATOM   3663 C CB  . ALA B 1 192 ? 18.29479  -1.55258  -7.22291  1.000 31.83904 ? 194 ALA B CB  1 
ATOM   3664 N N   . GLY B 1 193 ? 19.72299  -4.21769  -5.70217  1.000 38.73038 ? 195 GLY B N   1 
ATOM   3665 C CA  . GLY B 1 193 ? 20.31706  -5.49127  -6.04715  1.000 40.25098 ? 195 GLY B CA  1 
ATOM   3666 C C   . GLY B 1 193 ? 19.88865  -5.94146  -7.43301  1.000 40.11800 ? 195 GLY B C   1 
ATOM   3667 O O   . GLY B 1 193 ? 19.01835  -5.35190  -8.07423  1.000 37.77664 ? 195 GLY B O   1 
ATOM   3668 N N   . THR B 1 194 ? 20.50795  -7.01607  -7.91216  1.000 36.83492 ? 196 THR B N   1 
ATOM   3669 C CA  . THR B 1 194 ? 20.12812  -7.52865  -9.22110  1.000 41.02783 ? 196 THR B CA  1 
ATOM   3670 C C   . THR B 1 194 ? 18.69953  -8.05837  -9.15750  1.000 39.57036 ? 196 THR B C   1 
ATOM   3671 O O   . THR B 1 194 ? 18.34406  -8.83794  -8.26525  1.000 42.83026 ? 196 THR B O   1 
ATOM   3672 C CB  . THR B 1 194 ? 21.08727  -8.61986  -9.69612  1.000 41.17875 ? 196 THR B CB  1 
ATOM   3673 O OG1 . THR B 1 194 ? 21.31894  -9.55329  -8.63454  1.000 48.96756 ? 196 THR B OG1 1 
ATOM   3674 C CG2 . THR B 1 194 ? 22.40928  -8.00024  -10.13902 1.000 43.03990 ? 196 THR B CG2 1 
ATOM   3675 N N   . ASP B 1 195 ? 17.87825  -7.60450  -10.08434 1.000 43.25328 ? 197 ASP B N   1 
ATOM   3676 C CA  . ASP B 1 195 ? 16.46885  -7.94859  -10.05855 1.000 38.94883 ? 197 ASP B CA  1 
ATOM   3677 C C   . ASP B 1 195 ? 16.21762  -9.22288  -10.85123 1.000 40.18399 ? 197 ASP B C   1 
ATOM   3678 O O   . ASP B 1 195 ? 17.05916  -9.68277  -11.62994 1.000 39.23040 ? 197 ASP B O   1 
ATOM   3679 C CB  . ASP B 1 195 ? 15.62553  -6.80735  -10.61420 1.000 40.00283 ? 197 ASP B CB  1 
ATOM   3680 C CG  . ASP B 1 195 ? 14.17325  -6.91036  -10.18536 1.000 36.25282 ? 197 ASP B CG  1 
ATOM   3681 O OD1 . ASP B 1 195 ? 13.92518  -7.46224  -9.08323  1.000 30.39965 ? 197 ASP B OD1 1 
ATOM   3682 O OD2 . ASP B 1 195 ? 13.29460  -6.47112  -10.95799 1.000 36.10733 ? 197 ASP B OD2 1 
ATOM   3683 N N   . THR B 1 196 ? 15.04673  -9.80610  -10.62402 1.000 37.57618 ? 198 THR B N   1 
ATOM   3684 C CA  . THR B 1 196 ? 14.61686  -10.98465 -11.34906 1.000 38.38300 ? 198 THR B CA  1 
ATOM   3685 C C   . THR B 1 196 ? 13.19675  -10.75846 -11.85423 1.000 37.51113 ? 198 THR B C   1 
ATOM   3686 O O   . THR B 1 196 ? 12.48799  -9.85250  -11.39827 1.000 35.69458 ? 198 THR B O   1 
ATOM   3687 C CB  . THR B 1 196 ? 14.69267  -12.23572 -10.46681 1.000 37.20907 ? 198 THR B CB  1 
ATOM   3688 O OG1 . THR B 1 196 ? 14.03118  -11.97675 -9.22728  1.000 37.74039 ? 198 THR B OG1 1 
ATOM   3689 C CG2 . THR B 1 196 ? 16.15939  -12.60896 -10.17883 1.000 39.34436 ? 198 THR B CG2 1 
ATOM   3690 N N   . THR B 1 197 ? 12.79929  -11.57888 -12.82179 1.000 36.67484 ? 199 THR B N   1 
ATOM   3691 C CA  . THR B 1 197 ? 11.44283  -11.52412 -13.35239 1.000 32.17617 ? 199 THR B CA  1 
ATOM   3692 C C   . THR B 1 197 ? 10.51183  -12.30873 -12.43134 1.000 34.79776 ? 199 THR B C   1 
ATOM   3693 O O   . THR B 1 197 ? 10.88810  -13.35175 -11.88884 1.000 31.44683 ? 199 THR B O   1 
ATOM   3694 C CB  . THR B 1 197 ? 11.41308  -12.07931 -14.77777 1.000 31.50914 ? 199 THR B CB  1 
ATOM   3695 O OG1 . THR B 1 197 ? 12.23723  -11.26486 -15.61409 1.000 34.84211 ? 199 THR B OG1 1 
ATOM   3696 C CG2 . THR B 1 197 ? 9.97451   -12.07021 -15.36057 1.000 31.97707 ? 199 THR B CG2 1 
ATOM   3697 N N   . ILE B 1 198 ? 9.29603   -11.79558 -12.23960 1.000 30.69539 ? 200 ILE B N   1 
ATOM   3698 C CA  . ILE B 1 198 ? 8.36560   -12.38185 -11.27870 1.000 33.68186 ? 200 ILE B CA  1 
ATOM   3699 C C   . ILE B 1 198 ? 7.63209   -13.51363 -11.99318 1.000 35.58332 ? 200 ILE B C   1 
ATOM   3700 O O   . ILE B 1 198 ? 6.66578   -13.28135 -12.72755 1.000 29.34429 ? 200 ILE B O   1 
ATOM   3701 C CB  . ILE B 1 198 ? 7.39593   -11.34324 -10.71040 1.000 32.40795 ? 200 ILE B CB  1 
ATOM   3702 C CG1 . ILE B 1 198 ? 8.16360   -10.12177 -10.17880 1.000 30.07280 ? 200 ILE B CG1 1 
ATOM   3703 C CG2 . ILE B 1 198 ? 6.54632   -11.96371 -9.61748  1.000 30.59560 ? 200 ILE B CG2 1 
ATOM   3704 C CD1 . ILE B 1 198 ? 7.38690   -8.81715  -10.26617 1.000 29.72908 ? 200 ILE B CD1 1 
ATOM   3705 N N   . THR B 1 199 ? 8.08042   -14.74783 -11.74609 1.000 33.31250 ? 201 THR B N   1 
ATOM   3706 C CA  . THR B 1 199 ? 7.62542   -15.90886 -12.51011 1.000 35.00342 ? 201 THR B CA  1 
ATOM   3707 C C   . THR B 1 199 ? 6.12496   -16.12049 -12.38644 1.000 33.38035 ? 201 THR B C   1 
ATOM   3708 O O   . THR B 1 199 ? 5.44302   -16.38778 -13.38021 1.000 33.76794 ? 201 THR B O   1 
ATOM   3709 C CB  . THR B 1 199 ? 8.36625   -17.16239 -12.04203 1.000 34.96638 ? 201 THR B CB  1 
ATOM   3710 O OG1 . THR B 1 199 ? 9.77025   -16.93587 -12.15020 1.000 33.40646 ? 201 THR B OG1 1 
ATOM   3711 C CG2 . THR B 1 199 ? 7.98112   -18.36993 -12.89194 1.000 35.80132 ? 201 THR B CG2 1 
ATOM   3712 N N   . VAL B 1 200 ? 5.59408   -16.05199 -11.16500 1.000 33.78288 ? 202 VAL B N   1 
ATOM   3713 C CA  . VAL B 1 200 ? 4.18466   -16.37061 -10.98292 1.000 30.74568 ? 202 VAL B CA  1 
ATOM   3714 C C   . VAL B 1 200 ? 3.30497   -15.35487 -11.70999 1.000 31.86941 ? 202 VAL B C   1 
ATOM   3715 O O   . VAL B 1 200 ? 2.18927   -15.68350 -12.13059 1.000 28.44502 ? 202 VAL B O   1 
ATOM   3716 C CB  . VAL B 1 200 ? 3.85109   -16.45881 -9.48108  1.000 31.12523 ? 202 VAL B CB  1 
ATOM   3717 C CG1 . VAL B 1 200 ? 3.99884   -15.09895 -8.83649  1.000 34.03588 ? 202 VAL B CG1 1 
ATOM   3718 C CG2 . VAL B 1 200 ? 2.44784   -17.02611 -9.26362  1.000 37.28194 ? 202 VAL B CG2 1 
ATOM   3719 N N   . ASN B 1 201 ? 3.79558   -14.11969 -11.89088 1.000 31.37804 ? 203 ASN B N   1 
ATOM   3720 C CA  . ASN B 1 201 ? 3.04172   -13.10637 -12.63290 1.000 30.82799 ? 203 ASN B CA  1 
ATOM   3721 C C   . ASN B 1 201 ? 3.08741   -13.36092 -14.13663 1.000 29.13151 ? 203 ASN B C   1 
ATOM   3722 O O   . ASN B 1 201 ? 2.07454   -13.18979 -14.82488 1.000 27.55991 ? 203 ASN B O   1 
ATOM   3723 C CB  . ASN B 1 201 ? 3.57502   -11.70152 -12.32561 1.000 27.53290 ? 203 ASN B CB  1 
ATOM   3724 C CG  . ASN B 1 201 ? 3.22566   -11.22077 -10.90741 1.000 29.07937 ? 203 ASN B CG  1 
ATOM   3725 O OD1 . ASN B 1 201 ? 2.61053   -11.94153 -10.12501 1.000 27.52630 ? 203 ASN B OD1 1 
ATOM   3726 N ND2 . ASN B 1 201 ? 3.64201   -10.00310 -10.57887 1.000 25.24462 ? 203 ASN B ND2 1 
ATOM   3727 N N   . VAL B 1 202 ? 4.25260   -13.74852 -14.67228 1.000 26.44834 ? 204 VAL B N   1 
ATOM   3728 C CA  . VAL B 1 202 ? 4.30917   -14.12749 -16.08168 1.000 27.15151 ? 204 VAL B CA  1 
ATOM   3729 C C   . VAL B 1 202 ? 3.33126   -15.26101 -16.35133 1.000 29.37238 ? 204 VAL B C   1 
ATOM   3730 O O   . VAL B 1 202 ? 2.56880   -15.22961 -17.32619 1.000 30.45497 ? 204 VAL B O   1 
ATOM   3731 C CB  . VAL B 1 202 ? 5.74155   -14.51736 -16.49631 1.000 29.45223 ? 204 VAL B CB  1 
ATOM   3732 C CG1 . VAL B 1 202 ? 5.74274   -15.06465 -17.92802 1.000 24.69901 ? 204 VAL B CG1 1 
ATOM   3733 C CG2 . VAL B 1 202 ? 6.67906   -13.32755 -16.39246 1.000 29.64437 ? 204 VAL B CG2 1 
ATOM   3734 N N   . LEU B 1 203 ? 3.32928   -16.27555 -15.48103 1.000 28.58132 ? 205 LEU B N   1 
ATOM   3735 C CA  . LEU B 1 203 ? 2.38867   -17.37891 -15.65301 1.000 30.09987 ? 205 LEU B CA  1 
ATOM   3736 C C   . LEU B 1 203 ? 0.95525   -16.87045 -15.63545 1.000 32.69302 ? 205 LEU B C   1 
ATOM   3737 O O   . LEU B 1 203 ? 0.14839   -17.25045 -16.48734 1.000 27.83453 ? 205 LEU B O   1 
ATOM   3738 C CB  . LEU B 1 203 ? 2.60910   -18.44709 -14.57625 1.000 33.89406 ? 205 LEU B CB  1 
ATOM   3739 C CG  . LEU B 1 203 ? 3.91968   -19.24100 -14.71055 1.000 32.41731 ? 205 LEU B CG  1 
ATOM   3740 C CD1 . LEU B 1 203 ? 4.14845   -20.14065 -13.49783 1.000 35.61137 ? 205 LEU B CD1 1 
ATOM   3741 C CD2 . LEU B 1 203 ? 3.94942   -20.05523 -16.00565 1.000 34.01395 ? 205 LEU B CD2 1 
ATOM   3742 N N   . ALA B 1 204 ? 0.62736   -15.98161 -14.68884 1.000 28.73580 ? 206 ALA B N   1 
ATOM   3743 C CA  . ALA B 1 204 ? -0.71213  -15.39158 -14.66254 1.000 28.33287 ? 206 ALA B CA  1 
ATOM   3744 C C   . ALA B 1 204 ? -1.05418  -14.72535 -15.98584 1.000 28.95801 ? 206 ALA B C   1 
ATOM   3745 O O   . ALA B 1 204 ? -2.17558  -14.85486 -16.49225 1.000 31.56137 ? 206 ALA B O   1 
ATOM   3746 C CB  . ALA B 1 204 ? -0.81220  -14.37971 -13.52055 1.000 30.08252 ? 206 ALA B CB  1 
ATOM   3747 N N   . TRP B 1 205 ? -0.08095  -14.03892 -16.57802 1.000 25.04945 ? 207 TRP B N   1 
ATOM   3748 C CA  . TRP B 1 205 ? -0.30120  -13.30052 -17.81465 1.000 27.98844 ? 207 TRP B CA  1 
ATOM   3749 C C   . TRP B 1 205 ? -0.48079  -14.23660 -19.00874 1.000 30.60694 ? 207 TRP B C   1 
ATOM   3750 O O   . TRP B 1 205 ? -1.26280  -13.93995 -19.92372 1.000 27.41272 ? 207 TRP B O   1 
ATOM   3751 C CB  . TRP B 1 205 ? 0.87558   -12.34613 -18.01825 1.000 28.79146 ? 207 TRP B CB  1 
ATOM   3752 C CG  . TRP B 1 205 ? 0.85284   -11.53070 -19.23408 1.000 29.67179 ? 207 TRP B CG  1 
ATOM   3753 C CD1 . TRP B 1 205 ? 0.12087   -10.40112 -19.45641 1.000 32.93052 ? 207 TRP B CD1 1 
ATOM   3754 C CD2 . TRP B 1 205 ? 1.63347   -11.74478 -20.40410 1.000 33.08744 ? 207 TRP B CD2 1 
ATOM   3755 N NE1 . TRP B 1 205 ? 0.38749   -9.90721  -20.70256 1.000 35.47325 ? 207 TRP B NE1 1 
ATOM   3756 C CE2 . TRP B 1 205 ? 1.31766   -10.71413 -21.30759 1.000 36.27493 ? 207 TRP B CE2 1 
ATOM   3757 C CE3 . TRP B 1 205 ? 2.56558   -12.71502 -20.78137 1.000 34.78677 ? 207 TRP B CE3 1 
ATOM   3758 C CZ2 . TRP B 1 205 ? 1.89527   -10.62767 -22.56492 1.000 38.09433 ? 207 TRP B CZ2 1 
ATOM   3759 C CZ3 . TRP B 1 205 ? 3.14444   -12.62530 -22.03564 1.000 41.37193 ? 207 TRP B CZ3 1 
ATOM   3760 C CH2 . TRP B 1 205 ? 2.80930   -11.58732 -22.91057 1.000 39.51049 ? 207 TRP B CH2 1 
ATOM   3761 N N   . LEU B 1 206 ? 0.24095   -15.36602 -19.02826 1.000 28.12843 ? 208 LEU B N   1 
ATOM   3762 C CA  . LEU B 1 206 ? -0.01645  -16.38582 -20.04748 1.000 28.95345 ? 208 LEU B CA  1 
ATOM   3763 C C   . LEU B 1 206 ? -1.43263  -16.95499 -19.91979 1.000 28.07400 ? 208 LEU B C   1 
ATOM   3764 O O   . LEU B 1 206 ? -2.08488  -17.25869 -20.92889 1.000 27.15537 ? 208 LEU B O   1 
ATOM   3765 C CB  . LEU B 1 206 ? 1.01885   -17.50901 -19.94287 1.000 24.12217 ? 208 LEU B CB  1 
ATOM   3766 C CG  . LEU B 1 206 ? 2.46205   -17.09112 -20.27991 1.000 27.96330 ? 208 LEU B CG  1 
ATOM   3767 C CD1 . LEU B 1 206 ? 3.44538   -18.20210 -19.92977 1.000 27.75228 ? 208 LEU B CD1 1 
ATOM   3768 C CD2 . LEU B 1 206 ? 2.61854   -16.68782 -21.75749 1.000 28.53664 ? 208 LEU B CD2 1 
ATOM   3769 N N   . TYR B 1 207 ? -1.91847  -17.13452 -18.68856 1.000 25.21121 ? 209 TYR B N   1 
ATOM   3770 C CA  . TYR B 1 207 ? -3.30863  -17.56722 -18.53069 1.000 28.97579 ? 209 TYR B CA  1 
ATOM   3771 C C   . TYR B 1 207 ? -4.27157  -16.52189 -19.08022 1.000 34.87395 ? 209 TYR B C   1 
ATOM   3772 O O   . TYR B 1 207 ? -5.31837  -16.87014 -19.64728 1.000 35.14872 ? 209 TYR B O   1 
ATOM   3773 C CB  . TYR B 1 207 ? -3.62835  -17.86051 -17.06091 1.000 30.70646 ? 209 TYR B CB  1 
ATOM   3774 C CG  . TYR B 1 207 ? -3.17559  -19.22554 -16.58029 1.000 33.39316 ? 209 TYR B CG  1 
ATOM   3775 C CD1 . TYR B 1 207 ? -3.86139  -20.38434 -16.95126 1.000 36.91478 ? 209 TYR B CD1 1 
ATOM   3776 C CD2 . TYR B 1 207 ? -2.06617  -19.35425 -15.75749 1.000 32.11882 ? 209 TYR B CD2 1 
ATOM   3777 C CE1 . TYR B 1 207 ? -3.45482  -21.63420 -16.50594 1.000 36.76573 ? 209 TYR B CE1 1 
ATOM   3778 C CE2 . TYR B 1 207 ? -1.64638  -20.59901 -15.30931 1.000 34.77014 ? 209 TYR B CE2 1 
ATOM   3779 C CZ  . TYR B 1 207 ? -2.34691  -21.73823 -15.68737 1.000 37.87894 ? 209 TYR B CZ  1 
ATOM   3780 O OH  . TYR B 1 207 ? -1.93248  -22.97622 -15.24489 1.000 37.23968 ? 209 TYR B OH  1 
ATOM   3781 N N   . ALA B 1 208 ? -3.94399  -15.23344 -18.90797 1.000 31.87548 ? 210 ALA B N   1 
ATOM   3782 C CA  . ALA B 1 208 ? -4.76412  -14.16953 -19.48464 1.000 33.52271 ? 210 ALA B CA  1 
ATOM   3783 C C   . ALA B 1 208 ? -4.76140  -14.24131 -21.00742 1.000 34.70198 ? 210 ALA B C   1 
ATOM   3784 O O   . ALA B 1 208 ? -5.80463  -14.05514 -21.65255 1.000 33.03126 ? 210 ALA B O   1 
ATOM   3785 C CB  . ALA B 1 208 ? -4.26449  -12.80262 -19.00627 1.000 34.08455 ? 210 ALA B CB  1 
ATOM   3786 N N   . ALA B 1 209 ? -3.59762  -14.51847 -21.59762 1.000 33.08760 ? 211 ALA B N   1 
ATOM   3787 C CA  . ALA B 1 209 ? -3.52217  -14.73240 -23.03871 1.000 33.91525 ? 211 ALA B CA  1 
ATOM   3788 C C   . ALA B 1 209 ? -4.41024  -15.89229 -23.47146 1.000 34.80304 ? 211 ALA B C   1 
ATOM   3789 O O   . ALA B 1 209 ? -5.11881  -15.79888 -24.48128 1.000 37.16052 ? 211 ALA B O   1 
ATOM   3790 C CB  . ALA B 1 209 ? -2.07267  -14.98456 -23.45247 1.000 32.33741 ? 211 ALA B CB  1 
ATOM   3791 N N   . VAL B 1 210 ? -4.40132  -16.98766 -22.70836 1.000 31.86094 ? 212 VAL B N   1 
ATOM   3792 C CA  . VAL B 1 210 ? -5.22065  -18.14105 -23.06545 1.000 34.55175 ? 212 VAL B CA  1 
ATOM   3793 C C   . VAL B 1 210 ? -6.70315  -17.80339 -22.93293 1.000 39.85163 ? 212 VAL B C   1 
ATOM   3794 O O   . VAL B 1 210 ? -7.50587  -18.12386 -23.81616 1.000 38.79279 ? 212 VAL B O   1 
ATOM   3795 C CB  . VAL B 1 210 ? -4.83321  -19.36069 -22.20806 1.000 35.60853 ? 212 VAL B CB  1 
ATOM   3796 C CG1 . VAL B 1 210 ? -5.89169  -20.45814 -22.32395 1.000 38.28069 ? 212 VAL B CG1 1 
ATOM   3797 C CG2 . VAL B 1 210 ? -3.44314  -19.88331 -22.61904 1.000 29.79880 ? 212 VAL B CG2 1 
ATOM   3798 N N   . ILE B 1 211 ? -7.08476  -17.14838 -21.83216 1.000 37.99041 ? 213 ILE B N   1 
ATOM   3799 C CA  . ILE B 1 211 ? -8.46396  -16.70226 -21.64536 1.000 37.93137 ? 213 ILE B CA  1 
ATOM   3800 C C   . ILE B 1 211 ? -8.90747  -15.81197 -22.79622 1.000 38.48071 ? 213 ILE B C   1 
ATOM   3801 O O   . ILE B 1 211 ? -10.08373 -15.82108 -23.18045 1.000 40.89045 ? 213 ILE B O   1 
ATOM   3802 C CB  . ILE B 1 211 ? -8.61123  -15.99378 -20.28213 1.000 35.03803 ? 213 ILE B CB  1 
ATOM   3803 C CG1 . ILE B 1 211 ? -8.33861  -16.99174 -19.16054 1.000 39.75825 ? 213 ILE B CG1 1 
ATOM   3804 C CG2 . ILE B 1 211 ? -10.01524 -15.41627 -20.10878 1.000 35.88208 ? 213 ILE B CG2 1 
ATOM   3805 C CD1 . ILE B 1 211 ? -8.45393  -16.41351 -17.76262 1.000 39.92400 ? 213 ILE B CD1 1 
ATOM   3806 N N   . ASN B 1 212 ? -7.98232  -15.06362 -23.39521 1.000 35.14864 ? 214 ASN B N   1 
ATOM   3807 C CA  . ASN B 1 212 ? -8.31696  -14.17380 -24.49484 1.000 40.22860 ? 214 ASN B CA  1 
ATOM   3808 C C   . ASN B 1 212 ? -8.00561  -14.77867 -25.86231 1.000 41.69674 ? 214 ASN B C   1 
ATOM   3809 O O   . ASN B 1 212 ? -7.87764  -14.03953 -26.84583 1.000 43.78022 ? 214 ASN B O   1 
ATOM   3810 C CB  . ASN B 1 212 ? -7.61168  -12.83061 -24.30563 1.000 39.95423 ? 214 ASN B CB  1 
ATOM   3811 C CG  . ASN B 1 212 ? -8.30421  -11.96416 -23.25544 1.000 48.35520 ? 214 ASN B CG  1 
ATOM   3812 O OD1 . ASN B 1 212 ? -9.22428  -11.21007 -23.57303 1.000 49.03617 ? 214 ASN B OD1 1 
ATOM   3813 N ND2 . ASN B 1 212 ? -7.88946  -12.09839 -21.99275 1.000 42.50501 ? 214 ASN B ND2 1 
ATOM   3814 N N   . GLY B 1 213 ? -7.87641  -16.10428 -25.94037 1.000 38.99795 ? 215 GLY B N   1 
ATOM   3815 C CA  . GLY B 1 213 ? -7.81652  -16.79851 -27.21405 1.000 41.69752 ? 215 GLY B CA  1 
ATOM   3816 C C   . GLY B 1 213 ? -6.45892  -16.88088 -27.87264 1.000 42.58248 ? 215 GLY B C   1 
ATOM   3817 O O   . GLY B 1 213 ? -6.37519  -17.32186 -29.02603 1.000 41.20369 ? 215 GLY B O   1 
ATOM   3818 N N   . ASP B 1 214 ? -5.39215  -16.47097 -27.18942 1.000 42.73945 ? 216 ASP B N   1 
ATOM   3819 C CA  . ASP B 1 214 ? -4.03416  -16.56211 -27.70903 1.000 39.47495 ? 216 ASP B CA  1 
ATOM   3820 C C   . ASP B 1 214 ? -3.40988  -17.82123 -27.11900 1.000 40.48608 ? 216 ASP B C   1 
ATOM   3821 O O   . ASP B 1 214 ? -3.04324  -17.84079 -25.93701 1.000 39.20202 ? 216 ASP B O   1 
ATOM   3822 C CB  . ASP B 1 214 ? -3.23342  -15.31330 -27.34073 1.000 44.84113 ? 216 ASP B CB  1 
ATOM   3823 C CG  . ASP B 1 214 ? -2.42539  -14.76275 -28.50015 1.000 50.98132 ? 216 ASP B CG  1 
ATOM   3824 O OD1 . ASP B 1 214 ? -2.43090  -15.36995 -29.59963 1.000 55.82586 ? 216 ASP B OD1 1 
ATOM   3825 O OD2 . ASP B 1 214 ? -1.78710  -13.70277 -28.30556 1.000 50.65001 ? 216 ASP B OD2 1 
ATOM   3826 N N   . ARG B 1 215 ? -3.29223  -18.87230 -27.94068 1.000 39.67511 ? 217 ARG B N   1 
ATOM   3827 C CA  . ARG B 1 215 ? -2.98293  -20.21300 -27.45301 1.000 37.24998 ? 217 ARG B CA  1 
ATOM   3828 C C   . ARG B 1 215 ? -1.81975  -20.88130 -28.18467 1.000 35.84463 ? 217 ARG B C   1 
ATOM   3829 O O   . ARG B 1 215 ? -1.52804  -22.05138 -27.90543 1.000 34.78807 ? 217 ARG B O   1 
ATOM   3830 C CB  . ARG B 1 215 ? -4.22972  -21.11540 -27.55520 1.000 38.69380 ? 217 ARG B CB  1 
ATOM   3831 C CG  . ARG B 1 215 ? -5.46736  -20.56055 -26.86406 1.000 44.61550 ? 217 ARG B CG  1 
ATOM   3832 C CD  . ARG B 1 215 ? -6.68447  -21.47524 -27.06087 1.000 44.73459 ? 217 ARG B CD  1 
ATOM   3833 N NE  . ARG B 1 215 ? -6.46134  -22.78943 -26.45664 1.000 51.52857 ? 217 ARG B NE  1 
ATOM   3834 C CZ  . ARG B 1 215 ? -7.07338  -23.23422 -25.36029 1.000 49.72835 ? 217 ARG B CZ  1 
ATOM   3835 N NH1 . ARG B 1 215 ? -6.78780  -24.44060 -24.89303 1.000 53.61156 ? 217 ARG B NH1 1 
ATOM   3836 N NH2 . ARG B 1 215 ? -7.97343  -22.48426 -24.73597 1.000 50.20156 ? 217 ARG B NH2 1 
ATOM   3837 N N   . TRP B 1 216 ? -1.13319  -20.17494 -29.09083 1.000 35.19968 ? 218 TRP B N   1 
ATOM   3838 C CA  . TRP B 1 216 ? -0.11299  -20.82301 -29.91688 1.000 36.81477 ? 218 TRP B CA  1 
ATOM   3839 C C   . TRP B 1 216 ? 1.04022   -21.37801 -29.09311 1.000 39.39337 ? 218 TRP B C   1 
ATOM   3840 O O   . TRP B 1 216 ? 1.74533   -22.28757 -29.55031 1.000 36.52062 ? 218 TRP B O   1 
ATOM   3841 C CB  . TRP B 1 216 ? 0.43181   -19.84697 -30.96619 1.000 40.63485 ? 218 TRP B CB  1 
ATOM   3842 C CG  . TRP B 1 216 ? 1.16585   -18.66466 -30.40450 1.000 38.43557 ? 218 TRP B CG  1 
ATOM   3843 C CD1 . TRP B 1 216 ? 0.65782   -17.41510 -30.18903 1.000 40.66400 ? 218 TRP B CD1 1 
ATOM   3844 C CD2 . TRP B 1 216 ? 2.54008   -18.61274 -29.99998 1.000 39.16951 ? 218 TRP B CD2 1 
ATOM   3845 N NE1 . TRP B 1 216 ? 1.62798   -16.58920 -29.67556 1.000 40.81756 ? 218 TRP B NE1 1 
ATOM   3846 C CE2 . TRP B 1 216 ? 2.79276   -17.29867 -29.55037 1.000 42.38525 ? 218 TRP B CE2 1 
ATOM   3847 C CE3 . TRP B 1 216 ? 3.58302   -19.54825 -29.97529 1.000 37.75747 ? 218 TRP B CE3 1 
ATOM   3848 C CZ2 . TRP B 1 216 ? 4.03558   -16.89964 -29.07560 1.000 39.11523 ? 218 TRP B CZ2 1 
ATOM   3849 C CZ3 . TRP B 1 216 ? 4.82159   -19.14784 -29.50462 1.000 39.62427 ? 218 TRP B CZ3 1 
ATOM   3850 C CH2 . TRP B 1 216 ? 5.03761   -17.83349 -29.06533 1.000 42.80074 ? 218 TRP B CH2 1 
ATOM   3851 N N   . PHE B 1 217 ? 1.27803   -20.83184 -27.90007 1.000 35.21840 ? 219 PHE B N   1 
ATOM   3852 C CA  . PHE B 1 217 ? 2.41621   -21.25584 -27.09360 1.000 34.77787 ? 219 PHE B CA  1 
ATOM   3853 C C   . PHE B 1 217 ? 2.11249   -22.46725 -26.22264 1.000 31.52101 ? 219 PHE B C   1 
ATOM   3854 O O   . PHE B 1 217 ? 3.02364   -22.97843 -25.56304 1.000 31.00164 ? 219 PHE B O   1 
ATOM   3855 C CB  . PHE B 1 217 ? 2.88535   -20.09807 -26.20895 1.000 33.86392 ? 219 PHE B CB  1 
ATOM   3856 C CG  . PHE B 1 217 ? 1.77360   -19.46982 -25.42033 1.000 29.58443 ? 219 PHE B CG  1 
ATOM   3857 C CD1 . PHE B 1 217 ? 1.36226   -20.01934 -24.20729 1.000 27.56474 ? 219 PHE B CD1 1 
ATOM   3858 C CD2 . PHE B 1 217 ? 1.12966   -18.34554 -25.89623 1.000 30.52076 ? 219 PHE B CD2 1 
ATOM   3859 C CE1 . PHE B 1 217 ? 0.32805   -19.44355 -23.48223 1.000 28.66687 ? 219 PHE B CE1 1 
ATOM   3860 C CE2 . PHE B 1 217 ? 0.08993   -17.76876 -25.17650 1.000 33.37592 ? 219 PHE B CE2 1 
ATOM   3861 C CZ  . PHE B 1 217 ? -0.30711  -18.31994 -23.97574 1.000 30.77728 ? 219 PHE B CZ  1 
ATOM   3862 N N   . LEU B 1 218 ? 0.86016   -22.92081 -26.18264 1.000 30.62384 ? 220 LEU B N   1 
ATOM   3863 C CA  . LEU B 1 218 ? 0.52712   -24.15095 -25.48081 1.000 30.82742 ? 220 LEU B CA  1 
ATOM   3864 C C   . LEU B 1 218 ? 1.12541   -25.34295 -26.21122 1.000 34.91037 ? 220 LEU B C   1 
ATOM   3865 O O   . LEU B 1 218 ? 1.15534   -25.38098 -27.44529 1.000 34.50189 ? 220 LEU B O   1 
ATOM   3866 C CB  . LEU B 1 218 ? -0.99141  -24.32490 -25.38224 1.000 31.62486 ? 220 LEU B CB  1 
ATOM   3867 C CG  . LEU B 1 218 ? -1.75947  -23.22014 -24.65652 1.000 33.61672 ? 220 LEU B CG  1 
ATOM   3868 C CD1 . LEU B 1 218 ? -3.23968  -23.54900 -24.61087 1.000 34.92824 ? 220 LEU B CD1 1 
ATOM   3869 C CD2 . LEU B 1 218 ? -1.19307  -23.04524 -23.25033 1.000 32.16090 ? 220 LEU B CD2 1 
ATOM   3870 N N   . ASN B 1 219 ? 1.59931   -26.32205 -25.44299 1.000 35.07025 ? 221 ASN B N   1 
ATOM   3871 C CA  . ASN B 1 219 ? 2.18732   -27.52967 -26.00403 1.000 38.02756 ? 221 ASN B CA  1 
ATOM   3872 C C   . ASN B 1 219 ? 1.72477   -28.73649 -25.19630 1.000 35.90892 ? 221 ASN B C   1 
ATOM   3873 O O   . ASN B 1 219 ? 1.05781   -28.61057 -24.16707 1.000 35.22009 ? 221 ASN B O   1 
ATOM   3874 C CB  . ASN B 1 219 ? 3.72282   -27.44778 -26.04378 1.000 37.36355 ? 221 ASN B CB  1 
ATOM   3875 C CG  . ASN B 1 219 ? 4.33123   -27.16467 -24.68225 1.000 36.17366 ? 221 ASN B CG  1 
ATOM   3876 O OD1 . ASN B 1 219 ? 3.95714   -27.76202 -23.67545 1.000 39.08656 ? 221 ASN B OD1 1 
ATOM   3877 N ND2 . ASN B 1 219 ? 5.27011   -26.23540 -24.64807 1.000 36.56165 ? 221 ASN B ND2 1 
ATOM   3878 N N   . ARG B 1 220 ? 2.08289   -29.92269 -25.68877 1.000 37.29245 ? 222 ARG B N   1 
ATOM   3879 C CA  . ARG B 1 220 ? 1.70484   -31.17884 -25.05419 1.000 33.94508 ? 222 ARG B CA  1 
ATOM   3880 C C   . ARG B 1 220 ? 2.53395   -31.48771 -23.81382 1.000 37.14053 ? 222 ARG B C   1 
ATOM   3881 O O   . ARG B 1 220 ? 2.24262   -32.45707 -23.10872 1.000 42.76449 ? 222 ARG B O   1 
ATOM   3882 C CB  . ARG B 1 220 ? 1.85837   -32.32279 -26.05893 1.000 38.77562 ? 222 ARG B CB  1 
ATOM   3883 C CG  . ARG B 1 220 ? 3.31097   -32.56906 -26.42034 1.000 36.13553 ? 222 ARG B CG  1 
ATOM   3884 C CD  . ARG B 1 220 ? 3.47480   -33.78817 -27.30036 1.000 39.37565 ? 222 ARG B CD  1 
ATOM   3885 N NE  . ARG B 1 220 ? 2.90434   -33.55524 -28.61784 1.000 36.80630 ? 222 ARG B NE  1 
ATOM   3886 C CZ  . ARG B 1 220 ? 1.82919   -34.18171 -29.08950 1.000 39.07272 ? 222 ARG B CZ  1 
ATOM   3887 N NH1 . ARG B 1 220 ? 1.20373   -35.09615 -28.35698 1.000 36.09914 ? 222 ARG B NH1 1 
ATOM   3888 N NH2 . ARG B 1 220 ? 1.38909   -33.89932 -30.30546 1.000 38.16837 ? 222 ARG B NH2 1 
ATOM   3889 N N   . PHE B 1 221 ? 3.54670   -30.69601 -23.52644 1.000 39.47639 ? 223 PHE B N   1 
ATOM   3890 C CA  . PHE B 1 221 ? 4.54523   -31.08889 -22.55290 1.000 40.82427 ? 223 PHE B CA  1 
ATOM   3891 C C   . PHE B 1 221 ? 4.22426   -30.53569 -21.17853 1.000 41.17143 ? 223 PHE B C   1 
ATOM   3892 O O   . PHE B 1 221 ? 3.37482   -29.66054 -20.99081 1.000 43.75473 ? 223 PHE B O   1 
ATOM   3893 C CB  . PHE B 1 221 ? 5.92958   -30.65023 -23.02170 1.000 40.24219 ? 223 PHE B CB  1 
ATOM   3894 C CG  . PHE B 1 221 ? 6.28676   -31.22144 -24.34497 1.000 41.42214 ? 223 PHE B CG  1 
ATOM   3895 C CD1 . PHE B 1 221 ? 6.31430   -32.59590 -24.51499 1.000 42.94163 ? 223 PHE B CD1 1 
ATOM   3896 C CD2 . PHE B 1 221 ? 6.52064   -30.40150 -25.43648 1.000 39.25860 ? 223 PHE B CD2 1 
ATOM   3897 C CE1 . PHE B 1 221 ? 6.61184   -33.14884 -25.73544 1.000 40.57835 ? 223 PHE B CE1 1 
ATOM   3898 C CE2 . PHE B 1 221 ? 6.81709   -30.95073 -26.66626 1.000 40.96163 ? 223 PHE B CE2 1 
ATOM   3899 C CZ  . PHE B 1 221 ? 6.85664   -32.32786 -26.81452 1.000 41.31110 ? 223 PHE B CZ  1 
ATOM   3900 N N   . THR B 1 222 ? 4.91389   -31.09637 -20.20120 1.000 43.97126 ? 224 THR B N   1 
ATOM   3901 C CA  . THR B 1 222 ? 4.74320   -30.72331 -18.81528 1.000 44.85174 ? 224 THR B CA  1 
ATOM   3902 C C   . THR B 1 222 ? 6.12143   -30.79090 -18.17531 1.000 46.65744 ? 224 THR B C   1 
ATOM   3903 O O   . THR B 1 222 ? 7.07716   -31.31194 -18.76219 1.000 45.81816 ? 224 THR B O   1 
ATOM   3904 C CB  . THR B 1 222 ? 3.71979   -31.63832 -18.14019 1.000 44.67406 ? 224 THR B CB  1 
ATOM   3905 O OG1 . THR B 1 222 ? 3.10186   -30.96764 -17.03974 1.000 53.31620 ? 224 THR B OG1 1 
ATOM   3906 C CG2 . THR B 1 222 ? 4.39485   -32.86060 -17.64591 1.000 45.90658 ? 224 THR B CG2 1 
ATOM   3907 N N   . THR B 1 223 ? 6.24295   -30.22076 -16.98535 1.000 44.99495 ? 225 THR B N   1 
ATOM   3908 C CA  . THR B 1 223 ? 7.52551   -30.20222 -16.30205 1.000 43.84924 ? 225 THR B CA  1 
ATOM   3909 C C   . THR B 1 223 ? 7.28066   -30.41063 -14.81864 1.000 46.10502 ? 225 THR B C   1 
ATOM   3910 O O   . THR B 1 223 ? 6.13560   -30.50258 -14.36135 1.000 47.86408 ? 225 THR B O   1 
ATOM   3911 C CB  . THR B 1 223 ? 8.27804   -28.89201 -16.57772 1.000 44.91815 ? 225 THR B CB  1 
ATOM   3912 O OG1 . THR B 1 223 ? 9.63498   -28.99820 -16.13153 1.000 47.84013 ? 225 THR B OG1 1 
ATOM   3913 C CG2 . THR B 1 223 ? 7.59244   -27.72763 -15.87247 1.000 44.07204 ? 225 THR B CG2 1 
ATOM   3914 N N   . THR B 1 224 ? 8.37511   -30.52933 -14.07791 1.000 50.32896 ? 226 THR B N   1 
ATOM   3915 C CA  . THR B 1 224 ? 8.35841   -30.58560 -12.62552 1.000 48.59415 ? 226 THR B CA  1 
ATOM   3916 C C   . THR B 1 224 ? 8.81841   -29.24891 -12.06342 1.000 44.81788 ? 226 THR B C   1 
ATOM   3917 O O   . THR B 1 224 ? 9.53083   -28.48709 -12.72362 1.000 41.38938 ? 226 THR B O   1 
ATOM   3918 C CB  . THR B 1 224 ? 9.27344   -31.69884 -12.10700 1.000 46.19715 ? 226 THR B CB  1 
ATOM   3919 O OG1 . THR B 1 224 ? 10.62541  -31.40223 -12.47304 1.000 49.66932 ? 226 THR B OG1 1 
ATOM   3920 C CG2 . THR B 1 224 ? 8.87424   -33.04296 -12.69689 1.000 52.51795 ? 226 THR B CG2 1 
ATOM   3921 N N   . LEU B 1 225 ? 8.40645   -28.97983 -10.82093 1.000 50.38126 ? 227 LEU B N   1 
ATOM   3922 C CA  . LEU B 1 225 ? 8.84188   -27.76700 -10.13228 1.000 48.02807 ? 227 LEU B CA  1 
ATOM   3923 C C   . LEU B 1 225 ? 10.36354  -27.64002 -10.14433 1.000 51.31056 ? 227 LEU B C   1 
ATOM   3924 O O   . LEU B 1 225 ? 10.91026  -26.58671 -10.49851 1.000 48.08533 ? 227 LEU B O   1 
ATOM   3925 C CB  . LEU B 1 225 ? 8.31021   -27.77022 -8.69995  1.000 50.80904 ? 227 LEU B CB  1 
ATOM   3926 C CG  . LEU B 1 225 ? 7.82031   -26.44621 -8.11502  1.000 54.66821 ? 227 LEU B CG  1 
ATOM   3927 C CD1 . LEU B 1 225 ? 7.21364   -25.56958 -9.20263  1.000 56.47346 ? 227 LEU B CD1 1 
ATOM   3928 C CD2 . LEU B 1 225 ? 6.80070   -26.71154 -7.02021  1.000 53.52762 ? 227 LEU B CD2 1 
ATOM   3929 N N   . ASN B 1 226 ? 11.06640  -28.72085 -9.78845  1.000 47.85699 ? 228 ASN B N   1 
ATOM   3930 C CA  . ASN B 1 226 ? 12.52502  -28.66370 -9.74519  1.000 52.10228 ? 228 ASN B CA  1 
ATOM   3931 C C   . ASN B 1 226 ? 13.11998  -28.45460 -11.13234 1.000 48.44885 ? 228 ASN B C   1 
ATOM   3932 O O   . ASN B 1 226 ? 14.04504  -27.65168 -11.30087 1.000 52.41975 ? 228 ASN B O   1 
ATOM   3933 C CB  . ASN B 1 226 ? 13.08453  -29.93273 -9.10406  1.000 57.09301 ? 228 ASN B CB  1 
ATOM   3934 C CG  . ASN B 1 226 ? 12.48914  -30.20229 -7.73336  1.000 63.19831 ? 228 ASN B CG  1 
ATOM   3935 O OD1 . ASN B 1 226 ? 12.21006  -31.35008 -7.37933  1.000 67.28127 ? 228 ASN B OD1 1 
ATOM   3936 N ND2 . ASN B 1 226 ? 12.27886  -29.14084 -6.95826  1.000 60.20635 ? 228 ASN B ND2 1 
ATOM   3937 N N   . ASP B 1 227 ? 12.61186  -29.16605 -12.14056 1.000 50.72218 ? 229 ASP B N   1 
ATOM   3938 C CA  . ASP B 1 227 ? 13.14408  -28.98317 -13.48821 1.000 50.82273 ? 229 ASP B CA  1 
ATOM   3939 C C   . ASP B 1 227 ? 12.89902  -27.56509 -13.98047 1.000 49.46279 ? 229 ASP B C   1 
ATOM   3940 O O   . ASP B 1 227 ? 13.74240  -26.97941 -14.67325 1.000 43.70393 ? 229 ASP B O   1 
ATOM   3941 C CB  . ASP B 1 227 ? 12.52306  -29.99608 -14.45101 1.000 53.79523 ? 229 ASP B CB  1 
ATOM   3942 C CG  . ASP B 1 227 ? 13.29402  -31.30475 -14.50108 1.000 61.58868 ? 229 ASP B CG  1 
ATOM   3943 O OD1 . ASP B 1 227 ? 14.54879  -31.26188 -14.46624 1.000 61.45946 ? 229 ASP B OD1 1 
ATOM   3944 O OD2 . ASP B 1 227 ? 12.64146  -32.37347 -14.57810 1.000 60.51679 ? 229 ASP B OD2 1 
ATOM   3945 N N   . PHE B 1 228 ? 11.74697  -26.99394 -13.62883 1.000 47.89319 ? 230 PHE B N   1 
ATOM   3946 C CA  . PHE B 1 228 ? 11.45675  -25.63091 -14.04978 1.000 47.17894 ? 230 PHE B CA  1 
ATOM   3947 C C   . PHE B 1 228 ? 12.41878  -24.64378 -13.40097 1.000 48.79477 ? 230 PHE B C   1 
ATOM   3948 O O   . PHE B 1 228 ? 12.99121  -23.77631 -14.07496 1.000 47.81118 ? 230 PHE B O   1 
ATOM   3949 C CB  . PHE B 1 228 ? 10.01073  -25.27462 -13.71378 1.000 46.29898 ? 230 PHE B CB  1 
ATOM   3950 C CG  . PHE B 1 228 ? 9.63032   -23.90507 -14.16117 1.000 48.29991 ? 230 PHE B CG  1 
ATOM   3951 C CD1 . PHE B 1 228 ? 9.31243   -23.66373 -15.48937 1.000 44.05205 ? 230 PHE B CD1 1 
ATOM   3952 C CD2 . PHE B 1 228 ? 9.63647   -22.84485 -13.26802 1.000 50.85733 ? 230 PHE B CD2 1 
ATOM   3953 C CE1 . PHE B 1 228 ? 8.98332   -22.39768 -15.91637 1.000 45.46479 ? 230 PHE B CE1 1 
ATOM   3954 C CE2 . PHE B 1 228 ? 9.31341   -21.57488 -13.68726 1.000 48.30802 ? 230 PHE B CE2 1 
ATOM   3955 C CZ  . PHE B 1 228 ? 8.98402   -21.34884 -15.01537 1.000 46.03801 ? 230 PHE B CZ  1 
ATOM   3956 N N   . ASN B 1 229 ? 12.62114  -24.77479 -12.08991 1.000 48.98166 ? 231 ASN B N   1 
ATOM   3957 C CA  . ASN B 1 229 ? 13.44800  -23.81493 -11.36922 1.000 48.68354 ? 231 ASN B CA  1 
ATOM   3958 C C   . ASN B 1 229 ? 14.89037  -23.83272 -11.85511 1.000 52.40988 ? 231 ASN B C   1 
ATOM   3959 O O   . ASN B 1 229 ? 15.57732  -22.80624 -11.79020 1.000 53.18956 ? 231 ASN B O   1 
ATOM   3960 C CB  . ASN B 1 229 ? 13.35574  -24.09180 -9.87050  1.000 50.08163 ? 231 ASN B CB  1 
ATOM   3961 C CG  . ASN B 1 229 ? 12.01504  -23.67776 -9.29920  1.000 50.74999 ? 231 ASN B CG  1 
ATOM   3962 O OD1 . ASN B 1 229 ? 11.45908  -22.65859 -9.70510  1.000 52.75647 ? 231 ASN B OD1 1 
ATOM   3963 N ND2 . ASN B 1 229 ? 11.47861  -24.46732 -8.37091  1.000 51.75236 ? 231 ASN B ND2 1 
ATOM   3964 N N   . LEU B 1 230 ? 15.36121  -24.97060 -12.37340 1.000 54.08960 ? 232 LEU B N   1 
ATOM   3965 C CA  . LEU B 1 230 ? 16.68707  -24.99055 -12.98447 1.000 50.09614 ? 232 LEU B CA  1 
ATOM   3966 C C   . LEU B 1 230 ? 16.75057  -24.06092 -14.19086 1.000 50.36985 ? 232 LEU B C   1 
ATOM   3967 O O   . LEU B 1 230 ? 17.73276  -23.33031 -14.37029 1.000 50.63684 ? 232 LEU B O   1 
ATOM   3968 C CB  . LEU B 1 230 ? 17.06982  -26.41656 -13.38047 1.000 52.54693 ? 232 LEU B CB  1 
ATOM   3969 C CG  . LEU B 1 230 ? 17.48273  -27.33778 -12.23067 1.000 54.29745 ? 232 LEU B CG  1 
ATOM   3970 C CD1 . LEU B 1 230 ? 17.75296  -28.73959 -12.74991 1.000 52.72542 ? 232 LEU B CD1 1 
ATOM   3971 C CD2 . LEU B 1 230 ? 18.69911  -26.78258 -11.49469 1.000 51.87619 ? 232 LEU B CD2 1 
ATOM   3972 N N   . VAL B 1 231 ? 15.70844  -24.06341 -15.02777 1.000 50.63178 ? 233 VAL B N   1 
ATOM   3973 C CA  . VAL B 1 231 ? 15.66783  -23.11325 -16.13517 1.000 50.30553 ? 233 VAL B CA  1 
ATOM   3974 C C   . VAL B 1 231 ? 15.39176  -21.70461 -15.61581 1.000 48.09651 ? 233 VAL B C   1 
ATOM   3975 O O   . VAL B 1 231 ? 15.92423  -20.71973 -16.14242 1.000 50.03617 ? 233 VAL B O   1 
ATOM   3976 C CB  . VAL B 1 231 ? 14.62767  -23.55136 -17.18486 1.000 51.69284 ? 233 VAL B CB  1 
ATOM   3977 C CG1 . VAL B 1 231 ? 14.73339  -22.68191 -18.43103 1.000 48.26838 ? 233 VAL B CG1 1 
ATOM   3978 C CG2 . VAL B 1 231 ? 14.81571  -25.02278 -17.54791 1.000 52.67127 ? 233 VAL B CG2 1 
ATOM   3979 N N   . ALA B 1 232 ? 14.56448  -21.58938 -14.57033 1.000 48.19371 ? 234 ALA B N   1 
ATOM   3980 C CA  . ALA B 1 232 ? 14.27075  -20.28742 -13.97234 1.000 46.77840 ? 234 ALA B CA  1 
ATOM   3981 C C   . ALA B 1 232 ? 15.54759  -19.57493 -13.53590 1.000 49.80613 ? 234 ALA B C   1 
ATOM   3982 O O   . ALA B 1 232 ? 15.79990  -18.42566 -13.92373 1.000 46.01451 ? 234 ALA B O   1 
ATOM   3983 C CB  . ALA B 1 232 ? 13.32564  -20.46677 -12.78495 1.000 49.14788 ? 234 ALA B CB  1 
ATOM   3984 N N   . MET B 1 233 ? 16.37147  -20.25176 -12.73215 1.000 50.60514 ? 235 MET B N   1 
ATOM   3985 C CA  . MET B 1 233 ? 17.63735  -19.66845 -12.30120 1.000 49.60840 ? 235 MET B CA  1 
ATOM   3986 C C   . MET B 1 233 ? 18.48233  -19.23075 -13.49219 1.000 50.37858 ? 235 MET B C   1 
ATOM   3987 O O   . MET B 1 233 ? 19.12755  -18.17656 -13.45025 1.000 52.44394 ? 235 MET B O   1 
ATOM   3988 C CB  . MET B 1 233 ? 18.40063  -20.67278 -11.43596 1.000 55.75369 ? 235 MET B CB  1 
ATOM   3989 N N   . LYS B 1 234 ? 18.46029  -20.00993 -14.57982 1.000 47.16517 ? 236 LYS B N   1 
ATOM   3990 C CA  . LYS B 1 234 ? 19.31984  -19.72006 -15.72522 1.000 44.98468 ? 236 LYS B CA  1 
ATOM   3991 C C   . LYS B 1 234 ? 18.93287  -18.41057 -16.40688 1.000 47.36139 ? 236 LYS B C   1 
ATOM   3992 O O   . LYS B 1 234 ? 19.80291  -17.68736 -16.90617 1.000 47.72396 ? 236 LYS B O   1 
ATOM   3993 C CB  . LYS B 1 234 ? 19.26892  -20.88405 -16.72153 1.000 52.75429 ? 236 LYS B CB  1 
ATOM   3994 C CG  . LYS B 1 234 ? 20.18836  -20.74242 -17.93651 1.000 54.78479 ? 236 LYS B CG  1 
ATOM   3995 C CD  . LYS B 1 234 ? 20.03455  -21.93384 -18.88931 1.000 56.47386 ? 236 LYS B CD  1 
ATOM   3996 C CE  . LYS B 1 234 ? 20.39691  -21.55763 -20.32622 1.000 61.43277 ? 236 LYS B CE  1 
ATOM   3997 N NZ  . LYS B 1 234 ? 19.71280  -22.43345 -21.33742 1.000 63.93736 ? 236 LYS B NZ  1 
ATOM   3998 N N   . TYR B 1 235 ? 17.63445  -18.09038 -16.45776 1.000 47.72666 ? 237 TYR B N   1 
ATOM   3999 C CA  . TYR B 1 235 ? 17.16890  -16.86490 -17.10140 1.000 47.01390 ? 237 TYR B CA  1 
ATOM   4000 C C   . TYR B 1 235 ? 16.74276  -15.80154 -16.09050 1.000 46.36390 ? 237 TYR B C   1 
ATOM   4001 O O   . TYR B 1 235 ? 15.99006  -14.88353 -16.43963 1.000 45.81944 ? 237 TYR B O   1 
ATOM   4002 C CB  . TYR B 1 235 ? 16.02889  -17.17237 -18.07495 1.000 49.09039 ? 237 TYR B CB  1 
ATOM   4003 C CG  . TYR B 1 235 ? 16.43978  -18.06946 -19.22041 1.000 45.71847 ? 237 TYR B CG  1 
ATOM   4004 C CD1 . TYR B 1 235 ? 16.93664  -17.53624 -20.40124 1.000 50.40836 ? 237 TYR B CD1 1 
ATOM   4005 C CD2 . TYR B 1 235 ? 16.33490  -19.45106 -19.11616 1.000 49.33135 ? 237 TYR B CD2 1 
ATOM   4006 C CE1 . TYR B 1 235 ? 17.31856  -18.35513 -21.44726 1.000 49.56036 ? 237 TYR B CE1 1 
ATOM   4007 C CE2 . TYR B 1 235 ? 16.71270  -20.27649 -20.15449 1.000 50.78219 ? 237 TYR B CE2 1 
ATOM   4008 C CZ  . TYR B 1 235 ? 17.20332  -19.72462 -21.31736 1.000 49.26575 ? 237 TYR B CZ  1 
ATOM   4009 O OH  . TYR B 1 235 ? 17.57792  -20.54776 -22.35599 1.000 54.52115 ? 237 TYR B OH  1 
ATOM   4010 N N   . ASN B 1 236 ? 17.22663  -15.91125 -14.85235 1.000 43.70405 ? 238 ASN B N   1 
ATOM   4011 C CA  . ASN B 1 236 ? 16.97032  -14.97014 -13.76196 1.000 42.33508 ? 238 ASN B CA  1 
ATOM   4012 C C   . ASN B 1 236 ? 15.48106  -14.66375 -13.60329 1.000 44.58475 ? 238 ASN B C   1 
ATOM   4013 O O   . ASN B 1 236 ? 15.03755  -13.51204 -13.61018 1.000 37.23321 ? 238 ASN B O   1 
ATOM   4014 C CB  . ASN B 1 236 ? 17.78826  -13.69445 -13.92703 1.000 46.87599 ? 238 ASN B CB  1 
ATOM   4015 C CG  . ASN B 1 236 ? 19.18122  -13.84610 -13.34686 1.000 54.98109 ? 238 ASN B CG  1 
ATOM   4016 O OD1 . ASN B 1 236 ? 19.79540  -14.90516 -13.46730 1.000 57.14802 ? 238 ASN B OD1 1 
ATOM   4017 N ND2 . ASN B 1 236 ? 19.66026  -12.81252 -12.65991 1.000 61.95954 ? 238 ASN B ND2 1 
ATOM   4018 N N   . TYR B 1 237 ? 14.72693  -15.74613 -13.45373 1.000 41.71297 ? 239 TYR B N   1 
ATOM   4019 C CA  . TYR B 1 237 ? 13.34116  -15.74717 -13.02230 1.000 40.82898 ? 239 TYR B CA  1 
ATOM   4020 C C   . TYR B 1 237 ? 13.30233  -16.17330 -11.56239 1.000 41.67749 ? 239 TYR B C   1 
ATOM   4021 O O   . TYR B 1 237 ? 14.10774  -16.99770 -11.12654 1.000 39.97509 ? 239 TYR B O   1 
ATOM   4022 C CB  . TYR B 1 237 ? 12.51284  -16.72111 -13.86873 1.000 36.12951 ? 239 TYR B CB  1 
ATOM   4023 C CG  . TYR B 1 237 ? 11.84432  -16.11244 -15.07739 1.000 35.20889 ? 239 TYR B CG  1 
ATOM   4024 C CD1 . TYR B 1 237 ? 12.57277  -15.40474 -16.02884 1.000 32.98254 ? 239 TYR B CD1 1 
ATOM   4025 C CD2 . TYR B 1 237 ? 10.46597  -16.24641 -15.26496 1.000 31.19492 ? 239 TYR B CD2 1 
ATOM   4026 C CE1 . TYR B 1 237 ? 11.95651  -14.84729 -17.13524 1.000 35.31249 ? 239 TYR B CE1 1 
ATOM   4027 C CE2 . TYR B 1 237 ? 9.84559   -15.69075 -16.35762 1.000 29.53498 ? 239 TYR B CE2 1 
ATOM   4028 C CZ  . TYR B 1 237 ? 10.58365  -14.99194 -17.28526 1.000 35.00190 ? 239 TYR B CZ  1 
ATOM   4029 O OH  . TYR B 1 237 ? 9.94823   -14.45250 -18.36798 1.000 35.97333 ? 239 TYR B OH  1 
ATOM   4030 N N   . GLU B 1 238 ? 12.38074  -15.59095 -10.80555 1.000 37.93941 ? 240 GLU B N   1 
ATOM   4031 C CA  . GLU B 1 238 ? 12.15261  -16.04528 -9.44290  1.000 41.84001 ? 240 GLU B CA  1 
ATOM   4032 C C   . GLU B 1 238 ? 11.83318  -17.53746 -9.44021  1.000 45.20052 ? 240 GLU B C   1 
ATOM   4033 O O   . GLU B 1 238 ? 11.09427  -18.01493 -10.30866 1.000 42.69864 ? 240 GLU B O   1 
ATOM   4034 C CB  . GLU B 1 238 ? 10.99478  -15.27627 -8.79596  1.000 38.63581 ? 240 GLU B CB  1 
ATOM   4035 C CG  . GLU B 1 238 ? 11.38639  -13.93789 -8.22532  1.000 43.41080 ? 240 GLU B CG  1 
ATOM   4036 C CD  . GLU B 1 238 ? 12.47082  -14.05732 -7.17081  1.000 45.01691 ? 240 GLU B CD  1 
ATOM   4037 O OE1 . GLU B 1 238 ? 13.62763  -13.68949 -7.46367  1.000 46.34510 ? 240 GLU B OE1 1 
ATOM   4038 O OE2 . GLU B 1 238 ? 12.16242  -14.52621 -6.05145  1.000 48.93507 ? 240 GLU B OE2 1 
ATOM   4039 N N   . PRO B 1 239 ? 12.37010  -18.30056 -8.49109  1.000 45.74052 ? 241 PRO B N   1 
ATOM   4040 C CA  . PRO B 1 239 ? 11.93539  -19.69288 -8.33638  1.000 47.91362 ? 241 PRO B CA  1 
ATOM   4041 C C   . PRO B 1 239 ? 10.43680  -19.77336 -8.08094  1.000 47.88727 ? 241 PRO B C   1 
ATOM   4042 O O   . PRO B 1 239 ? 9.85572   -18.93043 -7.39660  1.000 47.22677 ? 241 PRO B O   1 
ATOM   4043 C CB  . PRO B 1 239 ? 12.74047  -20.18083 -7.12627  1.000 48.39046 ? 241 PRO B CB  1 
ATOM   4044 C CG  . PRO B 1 239 ? 13.96033  -19.30353 -7.11894  1.000 45.53173 ? 241 PRO B CG  1 
ATOM   4045 C CD  . PRO B 1 239 ? 13.46905  -17.95631 -7.56844  1.000 46.90138 ? 241 PRO B CD  1 
ATOM   4046 N N   . LEU B 1 240 ? 9.80735   -20.79467 -8.64962  1.000 48.00785 ? 242 LEU B N   1 
ATOM   4047 C CA  . LEU B 1 240 ? 8.38460   -21.03092 -8.44340  1.000 49.56377 ? 242 LEU B CA  1 
ATOM   4048 C C   . LEU B 1 240 ? 8.18507   -21.93802 -7.23516  1.000 51.04868 ? 242 LEU B C   1 
ATOM   4049 O O   . LEU B 1 240 ? 8.80245   -23.00354 -7.14259  1.000 54.50652 ? 242 LEU B O   1 
ATOM   4050 C CB  . LEU B 1 240 ? 7.75660   -21.66254 -9.68858  1.000 50.20040 ? 242 LEU B CB  1 
ATOM   4051 C CG  . LEU B 1 240 ? 6.23099   -21.64508 -9.74424  1.000 49.40670 ? 242 LEU B CG  1 
ATOM   4052 C CD1 . LEU B 1 240 ? 5.74918   -20.24419 -10.08489 1.000 46.33163 ? 242 LEU B CD1 1 
ATOM   4053 C CD2 . LEU B 1 240 ? 5.72008   -22.65533 -10.75934 1.000 50.40938 ? 242 LEU B CD2 1 
ATOM   4054 N N   . THR B 1 241 ? 7.32331   -21.52127 -6.31805  1.000 49.32289 ? 243 THR B N   1 
ATOM   4055 C CA  . THR B 1 241 ? 7.04763   -22.29818 -5.11950  1.000 54.65684 ? 243 THR B CA  1 
ATOM   4056 C C   . THR B 1 241 ? 5.72685   -23.04317 -5.26389  1.000 53.02115 ? 243 THR B C   1 
ATOM   4057 O O   . THR B 1 241 ? 4.91889   -22.76627 -6.15415  1.000 50.34644 ? 243 THR B O   1 
ATOM   4058 C CB  . THR B 1 241 ? 7.01703   -21.39584 -3.87796  1.000 53.95391 ? 243 THR B CB  1 
ATOM   4059 O OG1 . THR B 1 241 ? 5.80115   -20.63355 -3.86613  1.000 51.49536 ? 243 THR B OG1 1 
ATOM   4060 C CG2 . THR B 1 241 ? 8.22112   -20.45000 -3.87490  1.000 53.74660 ? 243 THR B CG2 1 
ATOM   4061 N N   . GLN B 1 242 ? 5.52062   -24.01620 -4.37119  1.000 52.84965 ? 244 GLN B N   1 
ATOM   4062 C CA  . GLN B 1 242 ? 4.22806   -24.69189 -4.31492  1.000 54.11295 ? 244 GLN B CA  1 
ATOM   4063 C C   . GLN B 1 242 ? 3.10844   -23.71485 -3.97953  1.000 51.88386 ? 244 GLN B C   1 
ATOM   4064 O O   . GLN B 1 242 ? 1.97534   -23.88530 -4.44236  1.000 52.51549 ? 244 GLN B O   1 
ATOM   4065 C CB  . GLN B 1 242 ? 4.27121   -25.83663 -3.29672  1.000 53.73041 ? 244 GLN B CB  1 
ATOM   4066 C CG  . GLN B 1 242 ? 2.93185   -26.52784 -3.05908  1.000 54.62190 ? 244 GLN B CG  1 
ATOM   4067 C CD  . GLN B 1 242 ? 2.31505   -27.09116 -4.33449  1.000 55.35438 ? 244 GLN B CD  1 
ATOM   4068 O OE1 . GLN B 1 242 ? 1.11700   -26.94704 -4.57194  1.000 55.09790 ? 244 GLN B OE1 1 
ATOM   4069 N NE2 . GLN B 1 242 ? 3.13210   -27.73996 -5.15478  1.000 54.65633 ? 244 GLN B NE2 1 
ATOM   4070 N N   . ASP B 1 243 ? 3.40316   -22.67998 -3.19005  1.000 52.85019 ? 245 ASP B N   1 
ATOM   4071 C CA  . ASP B 1 243 ? 2.38183   -21.67910 -2.89395  1.000 56.08400 ? 245 ASP B CA  1 
ATOM   4072 C C   . ASP B 1 243 ? 2.01514   -20.88779 -4.14366  1.000 50.84534 ? 245 ASP B C   1 
ATOM   4073 O O   . ASP B 1 243 ? 0.84513   -20.53772 -4.34464  1.000 50.78007 ? 245 ASP B O   1 
ATOM   4074 C CB  . ASP B 1 243 ? 2.86361   -20.74558 -1.78063  1.000 60.42553 ? 245 ASP B CB  1 
ATOM   4075 C CG  . ASP B 1 243 ? 2.00311   -19.50078 -1.65002  1.000 61.95120 ? 245 ASP B CG  1 
ATOM   4076 O OD1 . ASP B 1 243 ? 0.78605   -19.63603 -1.37459  1.000 61.55508 ? 245 ASP B OD1 1 
ATOM   4077 O OD2 . ASP B 1 243 ? 2.54555   -18.38726 -1.83439  1.000 62.38450 ? 245 ASP B OD2 1 
ATOM   4078 N N   . HIS B 1 244 ? 3.00637   -20.59030 -4.98800  1.000 50.91385 ? 246 HIS B N   1 
ATOM   4079 C CA  . HIS B 1 244 ? 2.72439   -20.00250 -6.29358  1.000 49.24015 ? 246 HIS B CA  1 
ATOM   4080 C C   . HIS B 1 244 ? 1.80785   -20.90594 -7.10647  1.000 49.12844 ? 246 HIS B C   1 
ATOM   4081 O O   . HIS B 1 244 ? 0.78823   -20.45997 -7.64863  1.000 47.93833 ? 246 HIS B O   1 
ATOM   4082 C CB  . HIS B 1 244 ? 4.02914   -19.76504 -7.04341  1.000 45.97358 ? 246 HIS B CB  1 
ATOM   4083 C CG  . HIS B 1 244 ? 4.88293   -18.69137 -6.45209  1.000 46.42170 ? 246 HIS B CG  1 
ATOM   4084 N ND1 . HIS B 1 244 ? 6.24669   -18.63475 -6.64909  1.000 47.10787 ? 246 HIS B ND1 1 
ATOM   4085 C CD2 . HIS B 1 244 ? 4.56679   -17.62188 -5.68587  1.000 45.09650 ? 246 HIS B CD2 1 
ATOM   4086 C CE1 . HIS B 1 244 ? 6.73449   -17.57869 -6.02357  1.000 48.90017 ? 246 HIS B CE1 1 
ATOM   4087 N NE2 . HIS B 1 244 ? 5.73426   -16.94494 -5.43556  1.000 48.73531 ? 246 HIS B NE2 1 
ATOM   4088 N N   . VAL B 1 245 ? 2.16087   -22.19000 -7.19545  1.000 48.75254 ? 247 VAL B N   1 
ATOM   4089 C CA  . VAL B 1 245 ? 1.33586   -23.15604 -7.91707  1.000 49.36524 ? 247 VAL B CA  1 
ATOM   4090 C C   . VAL B 1 245 ? -0.10519  -23.10859 -7.42595  1.000 49.01467 ? 247 VAL B C   1 
ATOM   4091 O O   . VAL B 1 245 ? -1.05224  -23.15936 -8.22123  1.000 46.82174 ? 247 VAL B O   1 
ATOM   4092 C CB  . VAL B 1 245 ? 1.94330   -24.56620 -7.78181  1.000 49.00786 ? 247 VAL B CB  1 
ATOM   4093 C CG1 . VAL B 1 245 ? 1.01122   -25.61574 -8.35224  1.000 47.82574 ? 247 VAL B CG1 1 
ATOM   4094 C CG2 . VAL B 1 245 ? 3.31674   -24.62112 -8.45193  1.000 46.40077 ? 247 VAL B CG2 1 
ATOM   4095 N N   . ASP B 1 246 ? -0.29664  -22.96939 -6.11010  1.000 52.97073 ? 248 ASP B N   1 
ATOM   4096 C CA  . ASP B 1 246 ? -1.64435  -23.03980 -5.54697  1.000 50.72969 ? 248 ASP B CA  1 
ATOM   4097 C C   . ASP B 1 246 ? -2.46813  -21.79849 -5.87563  1.000 45.92235 ? 248 ASP B C   1 
ATOM   4098 O O   . ASP B 1 246 ? -3.66880  -21.90467 -6.15861  1.000 46.44253 ? 248 ASP B O   1 
ATOM   4099 C CB  . ASP B 1 246 ? -1.56809  -23.24753 -4.03540  1.000 56.19733 ? 248 ASP B CB  1 
ATOM   4100 C CG  . ASP B 1 246 ? -0.91061  -24.56447 -3.66302  1.000 60.19525 ? 248 ASP B CG  1 
ATOM   4101 O OD1 . ASP B 1 246 ? -1.16945  -25.57497 -4.35378  1.000 58.01029 ? 248 ASP B OD1 1 
ATOM   4102 O OD2 . ASP B 1 246 ? -0.13363  -24.58702 -2.68069  1.000 62.54157 ? 248 ASP B OD2 1 
ATOM   4103 N N   . ILE B 1 247 ? -1.85300  -20.61313 -5.84586  1.000 45.88317 ? 249 ILE B N   1 
ATOM   4104 C CA  . ILE B 1 247 ? -2.61961  -19.40159 -6.14118  1.000 48.62337 ? 249 ILE B CA  1 
ATOM   4105 C C   . ILE B 1 247 ? -2.98848  -19.32572 -7.62217  1.000 46.24386 ? 249 ILE B C   1 
ATOM   4106 O O   . ILE B 1 247 ? -3.97893  -18.67925 -7.98730  1.000 43.77234 ? 249 ILE B O   1 
ATOM   4107 C CB  . ILE B 1 247 ? -1.85678  -18.14229 -5.68473  1.000 47.86833 ? 249 ILE B CB  1 
ATOM   4108 C CG1 . ILE B 1 247 ? -0.67606  -17.84994 -6.60507  1.000 46.88781 ? 249 ILE B CG1 1 
ATOM   4109 C CG2 . ILE B 1 247 ? -1.38424  -18.28877 -4.23819  1.000 49.27927 ? 249 ILE B CG2 1 
ATOM   4110 C CD1 . ILE B 1 247 ? -0.10812  -16.47226 -6.40408  1.000 50.10968 ? 249 ILE B CD1 1 
ATOM   4111 N N   . LEU B 1 248 ? -2.21409  -19.97583 -8.49612  1.000 43.60782 ? 250 LEU B N   1 
ATOM   4112 C CA  . LEU B 1 248 ? -2.60940  -20.09951 -9.89720  1.000 45.11382 ? 250 LEU B CA  1 
ATOM   4113 C C   . LEU B 1 248 ? -3.71809  -21.12439 -10.10848 1.000 47.30529 ? 250 LEU B C   1 
ATOM   4114 O O   . LEU B 1 248 ? -4.22683  -21.24126 -11.22997 1.000 45.95854 ? 250 LEU B O   1 
ATOM   4115 C CB  . LEU B 1 248 ? -1.39690  -20.46894 -10.75346 1.000 43.93855 ? 250 LEU B CB  1 
ATOM   4116 C CG  . LEU B 1 248 ? -0.35006  -19.37003 -10.91445 1.000 39.84580 ? 250 LEU B CG  1 
ATOM   4117 C CD1 . LEU B 1 248 ? 0.97274   -19.94979 -11.39112 1.000 38.09877 ? 250 LEU B CD1 1 
ATOM   4118 C CD2 . LEU B 1 248 ? -0.86142  -18.28045 -11.87404 1.000 36.27948 ? 250 LEU B CD2 1 
ATOM   4119 N N   . GLY B 1 249 ? -4.10364  -21.85573 -9.06383  1.000 45.67231 ? 251 GLY B N   1 
ATOM   4120 C CA  . GLY B 1 249 ? -5.12545  -22.87368 -9.15006  1.000 46.30688 ? 251 GLY B CA  1 
ATOM   4121 C C   . GLY B 1 249 ? -6.39966  -22.46727 -9.86963  1.000 47.99479 ? 251 GLY B C   1 
ATOM   4122 O O   . GLY B 1 249 ? -6.84534  -23.15330 -10.79644 1.000 47.66652 ? 251 GLY B O   1 
ATOM   4123 N N   . PRO B 1 250 ? -7.03271  -21.36290 -9.44806  1.000 46.21775 ? 252 PRO B N   1 
ATOM   4124 C CA  . PRO B 1 250 ? -8.27837  -20.95404 -10.12901 1.000 46.73299 ? 252 PRO B CA  1 
ATOM   4125 C C   . PRO B 1 250 ? -8.09825  -20.69000 -11.61319 1.000 45.72862 ? 252 PRO B C   1 
ATOM   4126 O O   . PRO B 1 250 ? -9.00165  -20.99507 -12.39876 1.000 46.53082 ? 252 PRO B O   1 
ATOM   4127 C CB  . PRO B 1 250 ? -8.71544  -19.68717 -9.36910  1.000 47.13502 ? 252 PRO B CB  1 
ATOM   4128 C CG  . PRO B 1 250 ? -7.58041  -19.32360 -8.46402  1.000 48.23055 ? 252 PRO B CG  1 
ATOM   4129 C CD  . PRO B 1 250 ? -6.78315  -20.57655 -8.22685  1.000 49.24005 ? 252 PRO B CD  1 
ATOM   4130 N N   . LEU B 1 251 ? -6.96008  -20.13036 -12.03010 1.000 43.17835 ? 253 LEU B N   1 
ATOM   4131 C CA  . LEU B 1 251 ? -6.73429  -19.94047 -13.45973 1.000 43.38993 ? 253 LEU B CA  1 
ATOM   4132 C C   . LEU B 1 251 ? -6.55187  -21.27976 -14.16406 1.000 43.06406 ? 253 LEU B C   1 
ATOM   4133 O O   . LEU B 1 251 ? -7.02094  -21.46323 -15.29268 1.000 39.51732 ? 253 LEU B O   1 
ATOM   4134 C CB  . LEU B 1 251 ? -5.52020  -19.03407 -13.68928 1.000 42.58438 ? 253 LEU B CB  1 
ATOM   4135 C CG  . LEU B 1 251 ? -5.72643  -17.56931 -13.29020 1.000 41.21598 ? 253 LEU B CG  1 
ATOM   4136 C CD1 . LEU B 1 251 ? -4.41748  -16.78945 -13.33019 1.000 34.67426 ? 253 LEU B CD1 1 
ATOM   4137 C CD2 . LEU B 1 251 ? -6.77821  -16.90890 -14.17425 1.000 39.56714 ? 253 LEU B CD2 1 
ATOM   4138 N N   . SER B 1 252 ? -5.87367  -22.22723 -13.50854 1.000 42.86317 ? 254 SER B N   1 
ATOM   4139 C CA  . SER B 1 252 ? -5.71479  -23.56215 -14.07643 1.000 43.45788 ? 254 SER B CA  1 
ATOM   4140 C C   . SER B 1 252 ? -7.05605  -24.27436 -14.19262 1.000 45.49395 ? 254 SER B C   1 
ATOM   4141 O O   . SER B 1 252 ? -7.30930  -24.98695 -15.17266 1.000 45.32523 ? 254 SER B O   1 
ATOM   4142 C CB  . SER B 1 252 ? -4.74169  -24.37503 -13.22168 1.000 46.04666 ? 254 SER B CB  1 
ATOM   4143 O OG  . SER B 1 252 ? -4.93635  -25.76353 -13.41000 1.000 47.68608 ? 254 SER B OG  1 
ATOM   4144 N N   . ALA B 1 253 ? -7.93267  -24.08903 -13.20199 1.000 45.90805 ? 255 ALA B N   1 
ATOM   4145 C CA  . ALA B 1 253 ? -9.26256  -24.67999 -13.27661 1.000 47.63193 ? 255 ALA B CA  1 
ATOM   4146 C C   . ALA B 1 253 ? -10.09293 -24.03606 -14.38382 1.000 44.25319 ? 255 ALA B C   1 
ATOM   4147 O O   . ALA B 1 253 ? -10.81914 -24.73100 -15.10511 1.000 48.22814 ? 255 ALA B O   1 
ATOM   4148 C CB  . ALA B 1 253 ? -9.96219  -24.55606 -11.92323 1.000 47.45661 ? 255 ALA B CB  1 
ATOM   4149 N N   . GLN B 1 254 ? -9.97562  -22.71618 -14.56271 1.000 42.53509 ? 256 GLN B N   1 
ATOM   4150 C CA  . GLN B 1 254 ? -10.81058 -22.03862 -15.55252 1.000 39.86274 ? 256 GLN B CA  1 
ATOM   4151 C C   . GLN B 1 254 ? -10.42677 -22.42689 -16.97792 1.000 42.30024 ? 256 GLN B C   1 
ATOM   4152 O O   . GLN B 1 254 ? -11.29618 -22.53770 -17.85135 1.000 39.87568 ? 256 GLN B O   1 
ATOM   4153 C CB  . GLN B 1 254 ? -10.71932 -20.52237 -15.37033 1.000 44.32079 ? 256 GLN B CB  1 
ATOM   4154 C CG  . GLN B 1 254 ? -11.30956 -19.71627 -16.53090 1.000 41.49141 ? 256 GLN B CG  1 
ATOM   4155 C CD  . GLN B 1 254 ? -11.30260 -18.21936 -16.26556 1.000 47.49886 ? 256 GLN B CD  1 
ATOM   4156 O OE1 . GLN B 1 254 ? -11.11895 -17.78028 -15.13007 1.000 53.06386 ? 256 GLN B OE1 1 
ATOM   4157 N NE2 . GLN B 1 254 ? -11.51797 -17.42914 -17.31119 1.000 47.11813 ? 256 GLN B NE2 1 
ATOM   4158 N N   . THR B 1 255 ? -9.13139  -22.63618 -17.23635 1.000 39.47462 ? 257 THR B N   1 
ATOM   4159 C CA  . THR B 1 255 ? -8.64304  -22.82349 -18.59803 1.000 39.93955 ? 257 THR B CA  1 
ATOM   4160 C C   . THR B 1 255 ? -8.39170  -24.27915 -18.96123 1.000 40.03295 ? 257 THR B C   1 
ATOM   4161 O O   . THR B 1 255 ? -8.29998  -24.59301 -20.15167 1.000 42.67045 ? 257 THR B O   1 
ATOM   4162 C CB  . THR B 1 255 ? -7.33137  -22.04578 -18.81672 1.000 35.02988 ? 257 THR B CB  1 
ATOM   4163 O OG1 . THR B 1 255 ? -6.34816  -22.51381 -17.88632 1.000 33.96294 ? 257 THR B OG1 1 
ATOM   4164 C CG2 . THR B 1 255 ? -7.53673  -20.54697 -18.64260 1.000 31.72937 ? 257 THR B CG2 1 
ATOM   4165 N N   . GLY B 1 256 ? -8.25510  -25.16454 -17.97875 1.000 39.66783 ? 258 GLY B N   1 
ATOM   4166 C CA  . GLY B 1 256 ? -7.87782  -26.53235 -18.25308 1.000 40.71686 ? 258 GLY B CA  1 
ATOM   4167 C C   . GLY B 1 256 ? -6.38974  -26.77228 -18.41902 1.000 40.57998 ? 258 GLY B C   1 
ATOM   4168 O O   . GLY B 1 256 ? -5.99040  -27.90334 -18.72591 1.000 41.02825 ? 258 GLY B O   1 
ATOM   4169 N N   . ILE B 1 257 ? -5.55130  -25.76395 -18.22215 1.000 35.55845 ? 259 ILE B N   1 
ATOM   4170 C CA  . ILE B 1 257 ? -4.10998  -25.93016 -18.35985 1.000 37.18324 ? 259 ILE B CA  1 
ATOM   4171 C C   . ILE B 1 257 ? -3.52358  -25.97737 -16.95670 1.000 39.68605 ? 259 ILE B C   1 
ATOM   4172 O O   . ILE B 1 257 ? -3.56759  -24.98784 -16.21947 1.000 37.90299 ? 259 ILE B O   1 
ATOM   4173 C CB  . ILE B 1 257 ? -3.48845  -24.81428 -19.20469 1.000 34.25345 ? 259 ILE B CB  1 
ATOM   4174 C CG1 . ILE B 1 257 ? -4.17141  -24.74764 -20.56837 1.000 35.11899 ? 259 ILE B CG1 1 
ATOM   4175 C CG2 . ILE B 1 257 ? -1.98422  -25.04493 -19.39532 1.000 34.90670 ? 259 ILE B CG2 1 
ATOM   4176 C CD1 . ILE B 1 257 ? -4.36421  -23.35313 -21.03735 1.000 38.57512 ? 259 ILE B CD1 1 
ATOM   4177 N N   . ALA B 1 258 ? -3.00214  -27.13691 -16.57340 1.000 36.03739 ? 260 ALA B N   1 
ATOM   4178 C CA  . ALA B 1 258 ? -2.36472  -27.26311 -15.27386 1.000 38.74405 ? 260 ALA B CA  1 
ATOM   4179 C C   . ALA B 1 258 ? -1.14370  -26.35561 -15.20432 1.000 41.55919 ? 260 ALA B C   1 
ATOM   4180 O O   . ALA B 1 258 ? -0.52232  -26.03122 -16.22380 1.000 40.81469 ? 260 ALA B O   1 
ATOM   4181 C CB  . ALA B 1 258 ? -1.95825  -28.71313 -15.01450 1.000 38.22555 ? 260 ALA B CB  1 
ATOM   4182 N N   . VAL B 1 259 ? -0.80430  -25.93525 -13.98384 1.000 37.48130 ? 261 VAL B N   1 
ATOM   4183 C CA  . VAL B 1 259 ? 0.29104   -24.98302 -13.81397 1.000 41.35691 ? 261 VAL B CA  1 
ATOM   4184 C C   . VAL B 1 259 ? 1.58141   -25.54180 -14.39170 1.000 37.95884 ? 261 VAL B C   1 
ATOM   4185 O O   . VAL B 1 259 ? 2.34432   -24.82392 -15.05028 1.000 37.05947 ? 261 VAL B O   1 
ATOM   4186 C CB  . VAL B 1 259 ? 0.45438   -24.60294 -12.32980 1.000 41.87583 ? 261 VAL B CB  1 
ATOM   4187 C CG1 . VAL B 1 259 ? 1.66853   -23.70217 -12.14232 1.000 37.27848 ? 261 VAL B CG1 1 
ATOM   4188 C CG2 . VAL B 1 259 ? -0.81492  -23.92969 -11.81911 1.000 43.25354 ? 261 VAL B CG2 1 
ATOM   4189 N N   . LEU B 1 260 ? 1.84533   -26.83230 -14.16690 1.000 39.28246 ? 262 LEU B N   1 
ATOM   4190 C CA  . LEU B 1 260 ? 3.07390   -27.42494 -14.68678 1.000 38.65663 ? 262 LEU B CA  1 
ATOM   4191 C C   . LEU B 1 260 ? 3.02254   -27.62169 -16.19883 1.000 39.16908 ? 262 LEU B C   1 
ATOM   4192 O O   . LEU B 1 260 ? 4.07999   -27.71922 -16.83823 1.000 39.65667 ? 262 LEU B O   1 
ATOM   4193 C CB  . LEU B 1 260 ? 3.35540   -28.74864 -13.97623 1.000 40.62328 ? 262 LEU B CB  1 
ATOM   4194 C CG  . LEU B 1 260 ? 3.54533   -28.63886 -12.45639 1.000 41.89220 ? 262 LEU B CG  1 
ATOM   4195 C CD1 . LEU B 1 260 ? 3.70092   -30.01525 -11.82192 1.000 46.52914 ? 262 LEU B CD1 1 
ATOM   4196 C CD2 . LEU B 1 260 ? 4.71736   -27.74076 -12.09420 1.000 41.52702 ? 262 LEU B CD2 1 
ATOM   4197 N N   . ASP B 1 261 ? 1.82176   -27.68385 -16.77984 1.000 34.47589 ? 263 ASP B N   1 
ATOM   4198 C CA  . ASP B 1 261 ? 1.69182   -27.60268 -18.23271 1.000 39.11263 ? 263 ASP B CA  1 
ATOM   4199 C C   . ASP B 1 261 ? 2.09446   -26.21882 -18.73423 1.000 36.88978 ? 263 ASP B C   1 
ATOM   4200 O O   . ASP B 1 261 ? 2.86478   -26.09628 -19.69127 1.000 32.19722 ? 263 ASP B O   1 
ATOM   4201 C CB  . ASP B 1 261 ? 0.25564   -27.93836 -18.64722 1.000 39.33077 ? 263 ASP B CB  1 
ATOM   4202 C CG  . ASP B 1 261 ? 0.06804   -28.00463 -20.16750 1.000 42.85823 ? 263 ASP B CG  1 
ATOM   4203 O OD1 . ASP B 1 261 ? 1.06285   -27.90834 -20.92664 1.000 47.99317 ? 263 ASP B OD1 1 
ATOM   4204 O OD2 . ASP B 1 261 ? -1.09971  -28.16778 -20.60137 1.000 46.72497 ? 263 ASP B OD2 1 
ATOM   4205 N N   . MET B 1 262 ? 1.58336   -25.15874 -18.08999 1.000 37.33114 ? 264 MET B N   1 
ATOM   4206 C CA  . MET B 1 262 ? 1.95031   -23.80626 -18.49068 1.000 29.87155 ? 264 MET B CA  1 
ATOM   4207 C C   . MET B 1 262 ? 3.41727   -23.51543 -18.21024 1.000 36.34571 ? 264 MET B C   1 
ATOM   4208 O O   . MET B 1 262 ? 4.03749   -22.73891 -18.94777 1.000 32.88622 ? 264 MET B O   1 
ATOM   4209 C CB  . MET B 1 262 ? 1.05785   -22.78535 -17.78380 1.000 35.33828 ? 264 MET B CB  1 
ATOM   4210 C CG  . MET B 1 262 ? 1.12875   -21.36149 -18.35809 1.000 32.59120 ? 264 MET B CG  1 
ATOM   4211 S SD  . MET B 1 262 ? 0.39114   -21.14956 -19.99870 1.000 31.06626 ? 264 MET B SD  1 
ATOM   4212 C CE  . MET B 1 262 ? -1.32367  -20.84118 -19.59646 1.000 29.74470 ? 264 MET B CE  1 
ATOM   4213 N N   . CYS B 1 263 ? 3.98957   -24.11619 -17.15583 1.000 33.73280 ? 265 CYS B N   1 
ATOM   4214 C CA  . CYS B 1 263 ? 5.42398   -23.95675 -16.91815 1.000 38.28352 ? 265 CYS B CA  1 
ATOM   4215 C C   . CYS B 1 263 ? 6.23003   -24.54101 -18.07217 1.000 35.26284 ? 265 CYS B C   1 
ATOM   4216 O O   . CYS B 1 263 ? 7.29733   -24.01662 -18.42854 1.000 36.31630 ? 265 CYS B O   1 
ATOM   4217 C CB  . CYS B 1 263 ? 5.83330   -24.61370 -15.59084 1.000 37.20611 ? 265 CYS B CB  1 
ATOM   4218 S SG  . CYS B 1 263 ? 5.32336   -23.73603 -14.09772 1.000 40.00650 ? 265 CYS B SG  1 
ATOM   4219 N N   . ALA B 1 264 ? 5.73064   -25.62847 -18.67083 1.000 36.73664 ? 266 ALA B N   1 
ATOM   4220 C CA  . ALA B 1 264 ? 6.36890   -26.17270 -19.86731 1.000 38.83887 ? 266 ALA B CA  1 
ATOM   4221 C C   . ALA B 1 264 ? 6.34140   -25.16488 -21.00781 1.000 37.05343 ? 266 ALA B C   1 
ATOM   4222 O O   . ALA B 1 264 ? 7.34223   -24.99176 -21.71430 1.000 36.37144 ? 266 ALA B O   1 
ATOM   4223 C CB  . ALA B 1 264 ? 5.68941   -27.47560 -20.29145 1.000 40.82506 ? 266 ALA B CB  1 
ATOM   4224 N N   . SER B 1 265 ? 5.20640   -24.47534 -21.19295 1.000 35.78689 ? 267 SER B N   1 
ATOM   4225 C CA  . SER B 1 265 ? 5.13992   -23.41794 -22.19979 1.000 34.58181 ? 267 SER B CA  1 
ATOM   4226 C C   . SER B 1 265 ? 6.14447   -22.31298 -21.89986 1.000 31.16366 ? 267 SER B C   1 
ATOM   4227 O O   . SER B 1 265 ? 6.85266   -21.84505 -22.79432 1.000 32.43077 ? 267 SER B O   1 
ATOM   4228 C CB  . SER B 1 265 ? 3.72029   -22.84483 -22.27374 1.000 32.17614 ? 267 SER B CB  1 
ATOM   4229 O OG  . SER B 1 265 ? 2.84747   -23.73400 -22.94480 1.000 35.90834 ? 267 SER B OG  1 
ATOM   4230 N N   . LEU B 1 266 ? 6.21208   -21.87449 -20.63991 1.000 30.39673 ? 268 LEU B N   1 
ATOM   4231 C CA  . LEU B 1 266 ? 7.12238   -20.78715 -20.28773 1.000 31.97879 ? 268 LEU B CA  1 
ATOM   4232 C C   . LEU B 1 266 ? 8.57077   -21.19962 -20.48530 1.000 30.77254 ? 268 LEU B C   1 
ATOM   4233 O O   . LEU B 1 266 ? 9.37925   -20.41571 -20.99344 1.000 32.08051 ? 268 LEU B O   1 
ATOM   4234 C CB  . LEU B 1 266 ? 6.89279   -20.34384 -18.84343 1.000 27.86285 ? 268 LEU B CB  1 
ATOM   4235 C CG  . LEU B 1 266 ? 7.81611   -19.21621 -18.35934 1.000 31.58589 ? 268 LEU B CG  1 
ATOM   4236 C CD1 . LEU B 1 266 ? 7.76632   -18.01470 -19.29224 1.000 28.95636 ? 268 LEU B CD1 1 
ATOM   4237 C CD2 . LEU B 1 266 ? 7.47475   -18.80592 -16.94088 1.000 29.78245 ? 268 LEU B CD2 1 
ATOM   4238 N N   . LYS B 1 267 ? 8.91481   -22.42577 -20.08812 1.000 35.70220 ? 269 LYS B N   1 
ATOM   4239 C CA  . LYS B 1 267 ? 10.27769  -22.92161 -20.29008 1.000 37.89954 ? 269 LYS B CA  1 
ATOM   4240 C C   . LYS B 1 267 ? 10.65827  -22.90510 -21.76606 1.000 38.63396 ? 269 LYS B C   1 
ATOM   4241 O O   . LYS B 1 267 ? 11.75760  -22.46702 -22.13605 1.000 40.63888 ? 269 LYS B O   1 
ATOM   4242 C CB  . LYS B 1 267 ? 10.40896  -24.33204 -19.71764 1.000 41.58124 ? 269 LYS B CB  1 
ATOM   4243 C CG  . LYS B 1 267 ? 11.64901  -25.07204 -20.20221 1.000 45.39968 ? 269 LYS B CG  1 
ATOM   4244 C CD  . LYS B 1 267 ? 11.46729  -26.57686 -20.07701 1.000 54.49665 ? 269 LYS B CD  1 
ATOM   4245 C CE  . LYS B 1 267 ? 12.58961  -27.33256 -20.78217 1.000 53.09024 ? 269 LYS B CE  1 
ATOM   4246 N NZ  . LYS B 1 267 ? 13.34707  -28.19016 -19.82895 1.000 58.88632 ? 269 LYS B NZ  1 
ATOM   4247 N N   . GLU B 1 268 ? 9.75355   -23.37542 -22.63013 1.000 37.36464 ? 270 GLU B N   1 
ATOM   4248 C CA  . GLU B 1 268 ? 10.03660  -23.37498 -24.06213 1.000 39.78404 ? 270 GLU B CA  1 
ATOM   4249 C C   . GLU B 1 268 ? 10.17437  -21.95474 -24.58849 1.000 37.88506 ? 270 GLU B C   1 
ATOM   4250 O O   . GLU B 1 268 ? 11.03739  -21.67798 -25.43221 1.000 37.51405 ? 270 GLU B O   1 
ATOM   4251 C CB  . GLU B 1 268 ? 8.94128   -24.12486 -24.82247 1.000 40.66907 ? 270 GLU B CB  1 
ATOM   4252 C CG  . GLU B 1 268 ? 8.73780   -25.58059 -24.39533 1.000 44.66255 ? 270 GLU B CG  1 
ATOM   4253 C CD  . GLU B 1 268 ? 10.01735  -26.40557 -24.44224 1.000 48.69233 ? 270 GLU B CD  1 
ATOM   4254 O OE1 . GLU B 1 268 ? 10.33902  -27.06999 -23.42821 1.000 52.07503 ? 270 GLU B OE1 1 
ATOM   4255 O OE2 . GLU B 1 268 ? 10.70200  -26.38608 -25.48838 1.000 49.79571 ? 270 GLU B OE2 1 
ATOM   4256 N N   . LEU B 1 269 ? 9.33019   -21.03971 -24.09794 1.000 34.10426 ? 271 LEU B N   1 
ATOM   4257 C CA  . LEU B 1 269 ? 9.44370   -19.63833 -24.48695 1.000 34.27877 ? 271 LEU B CA  1 
ATOM   4258 C C   . LEU B 1 269 ? 10.80089  -19.06915 -24.09033 1.000 37.32094 ? 271 LEU B C   1 
ATOM   4259 O O   . LEU B 1 269 ? 11.41828  -18.31970 -24.85536 1.000 35.61580 ? 271 LEU B O   1 
ATOM   4260 C CB  . LEU B 1 269 ? 8.32296   -18.81929 -23.85044 1.000 33.33861 ? 271 LEU B CB  1 
ATOM   4261 C CG  . LEU B 1 269 ? 6.92146   -19.04831 -24.42267 1.000 34.00777 ? 271 LEU B CG  1 
ATOM   4262 C CD1 . LEU B 1 269 ? 5.84646   -18.53093 -23.46910 1.000 37.20728 ? 271 LEU B CD1 1 
ATOM   4263 C CD2 . LEU B 1 269 ? 6.79519   -18.40747 -25.78635 1.000 38.12697 ? 271 LEU B CD2 1 
ATOM   4264 N N   . LEU B 1 270 ? 11.27758  -19.40626 -22.89535 1.000 34.26662 ? 272 LEU B N   1 
ATOM   4265 C CA  . LEU B 1 270 ? 12.55215  -18.85475 -22.45114 1.000 36.64071 ? 272 LEU B CA  1 
ATOM   4266 C C   . LEU B 1 270 ? 13.71011  -19.45616 -23.23915 1.000 42.19623 ? 272 LEU B C   1 
ATOM   4267 O O   . LEU B 1 270 ? 14.62961  -18.73672 -23.65138 1.000 43.83301 ? 272 LEU B O   1 
ATOM   4268 C CB  . LEU B 1 270 ? 12.73359  -19.09071 -20.95439 1.000 33.41516 ? 272 LEU B CB  1 
ATOM   4269 C CG  . LEU B 1 270 ? 11.81329  -18.33724 -19.98752 1.000 37.27518 ? 272 LEU B CG  1 
ATOM   4270 C CD1 . LEU B 1 270 ? 12.06080  -18.79007 -18.54767 1.000 36.21528 ? 272 LEU B CD1 1 
ATOM   4271 C CD2 . LEU B 1 270 ? 11.95679  -16.81989 -20.13108 1.000 36.58883 ? 272 LEU B CD2 1 
ATOM   4272 N N   . GLN B 1 271 ? 13.66937  -20.76857 -23.48327 1.000 41.35863 ? 273 GLN B N   1 
ATOM   4273 C CA  . GLN B 1 271 ? 14.77483  -21.42760 -24.16876 1.000 44.15012 ? 273 GLN B CA  1 
ATOM   4274 C C   . GLN B 1 271 ? 14.79491  -21.13116 -25.66106 1.000 44.92335 ? 273 GLN B C   1 
ATOM   4275 O O   . GLN B 1 271 ? 15.87127  -21.06827 -26.25839 1.000 43.08154 ? 273 GLN B O   1 
ATOM   4276 C CB  . GLN B 1 271 ? 14.70961  -22.93957 -23.95088 1.000 42.57878 ? 273 GLN B CB  1 
ATOM   4277 C CG  . GLN B 1 271 ? 15.15820  -23.39712 -22.57330 1.000 45.38462 ? 273 GLN B CG  1 
ATOM   4278 C CD  . GLN B 1 271 ? 14.67193  -24.79820 -22.25456 1.000 49.28309 ? 273 GLN B CD  1 
ATOM   4279 O OE1 . GLN B 1 271 ? 13.82648  -25.34840 -22.96105 1.000 45.20482 ? 273 GLN B OE1 1 
ATOM   4280 N NE2 . GLN B 1 271 ? 15.19472  -25.37883 -21.18362 1.000 53.43995 ? 273 GLN B NE2 1 
ATOM   4281 N N   . ASN B 1 272 ? 13.63693  -20.94937 -26.28583 1.000 46.07439 ? 274 ASN B N   1 
ATOM   4282 C CA  . ASN B 1 272 ? 13.57932  -20.86317 -27.73671 1.000 43.29664 ? 274 ASN B CA  1 
ATOM   4283 C C   . ASN B 1 272 ? 13.03603  -19.54644 -28.27343 1.000 45.64095 ? 274 ASN B C   1 
ATOM   4284 O O   . ASN B 1 272 ? 13.11201  -19.32035 -29.48848 1.000 42.97926 ? 274 ASN B O   1 
ATOM   4285 C CB  . ASN B 1 272 ? 12.74212  -22.02610 -28.29546 1.000 47.25422 ? 274 ASN B CB  1 
ATOM   4286 C CG  . ASN B 1 272 ? 13.16119  -23.37381 -27.71969 1.000 49.58044 ? 274 ASN B CG  1 
ATOM   4287 O OD1 . ASN B 1 272 ? 14.32976  -23.76330 -27.80890 1.000 52.07683 ? 274 ASN B OD1 1 
ATOM   4288 N ND2 . ASN B 1 272 ? 12.21120  -24.09343 -27.13515 1.000 48.42521 ? 274 ASN B ND2 1 
ATOM   4289 N N   . GLY B 1 273 ? 12.50340  -18.67144 -27.42237 1.000 45.08339 ? 275 GLY B N   1 
ATOM   4290 C CA  . GLY B 1 273 ? 11.95377  -17.41805 -27.89425 1.000 41.70775 ? 275 GLY B CA  1 
ATOM   4291 C C   . GLY B 1 273 ? 10.55279  -17.58388 -28.45397 1.000 43.96284 ? 275 GLY B C   1 
ATOM   4292 O O   . GLY B 1 273 ? 9.89697   -18.61410 -28.28302 1.000 40.90997 ? 275 GLY B O   1 
ATOM   4293 N N   . MET B 1 274 ? 10.10062  -16.54281 -29.15557 1.000 44.69667 ? 276 MET B N   1 
ATOM   4294 C CA  . MET B 1 274 ? 8.72845   -16.45768 -29.64039 1.000 49.33769 ? 276 MET B CA  1 
ATOM   4295 C C   . MET B 1 274 ? 8.58497   -16.73022 -31.13402 1.000 53.57528 ? 276 MET B C   1 
ATOM   4296 O O   . MET B 1 274 ? 7.45671   -16.72203 -31.63697 1.000 50.16004 ? 276 MET B O   1 
ATOM   4297 C CB  . MET B 1 274 ? 8.14284   -15.07749 -29.32202 1.000 49.68362 ? 276 MET B CB  1 
ATOM   4298 C CG  . MET B 1 274 ? 7.89354   -14.83127 -27.83454 1.000 49.33584 ? 276 MET B CG  1 
ATOM   4299 S SD  . MET B 1 274 ? 6.48640   -13.73609 -27.58493 1.000 55.84114 ? 276 MET B SD  1 
ATOM   4300 C CE  . MET B 1 274 ? 6.87108   -13.06479 -25.96629 1.000 50.40554 ? 276 MET B CE  1 
ATOM   4301 N N   . ASN B 1 275 ? 9.68900   -16.96709 -31.85253 1.000 48.37790 ? 277 ASN B N   1 
ATOM   4302 C CA  . ASN B 1 275 ? 9.65686   -17.22449 -33.29979 1.000 50.56163 ? 277 ASN B CA  1 
ATOM   4303 C C   . ASN B 1 275 ? 8.91563   -16.12235 -34.04868 1.000 50.61585 ? 277 ASN B C   1 
ATOM   4304 O O   . ASN B 1 275 ? 8.16031   -16.38243 -34.98696 1.000 56.00775 ? 277 ASN B O   1 
ATOM   4305 C CB  . ASN B 1 275 ? 9.02174   -18.58228 -33.61684 1.000 56.71341 ? 277 ASN B CB  1 
ATOM   4306 C CG  . ASN B 1 275 ? 9.47728   -19.67823 -32.67798 1.000 60.41203 ? 277 ASN B CG  1 
ATOM   4307 O OD1 . ASN B 1 275 ? 8.67634   -20.23065 -31.92146 1.000 62.98872 ? 277 ASN B OD1 1 
ATOM   4308 N ND2 . ASN B 1 275 ? 10.76850  -20.00625 -32.72520 1.000 60.62407 ? 277 ASN B ND2 1 
ATOM   4309 N N   . GLY B 1 276 ? 9.11259   -14.88062 -33.62045 1.000 54.60792 ? 278 GLY B N   1 
ATOM   4310 C CA  . GLY B 1 276 ? 8.43942   -13.77988 -34.27219 1.000 52.02494 ? 278 GLY B CA  1 
ATOM   4311 C C   . GLY B 1 276 ? 6.95510   -13.68732 -34.00947 1.000 55.62333 ? 278 GLY B C   1 
ATOM   4312 O O   . GLY B 1 276 ? 6.27888   -12.86068 -34.63271 1.000 52.73820 ? 278 GLY B O   1 
ATOM   4313 N N   . ARG B 1 277 ? 6.42034   -14.51398 -33.11768 1.000 49.89386 ? 279 ARG B N   1 
ATOM   4314 C CA  . ARG B 1 277 ? 5.03729   -14.37423 -32.70168 1.000 52.97827 ? 279 ARG B CA  1 
ATOM   4315 C C   . ARG B 1 277 ? 4.94430   -13.38411 -31.54065 1.000 52.71943 ? 279 ARG B C   1 
ATOM   4316 O O   . ARG B 1 277 ? 5.94842   -12.98085 -30.94670 1.000 52.70597 ? 279 ARG B O   1 
ATOM   4317 C CB  . ARG B 1 277 ? 4.45478   -15.73184 -32.29951 1.000 52.07712 ? 279 ARG B CB  1 
ATOM   4318 C CG  . ARG B 1 277 ? 4.07101   -16.65529 -33.45681 1.000 49.10703 ? 279 ARG B CG  1 
ATOM   4319 C CD  . ARG B 1 277 ? 3.01586   -16.02340 -34.36552 1.000 54.08734 ? 279 ARG B CD  1 
ATOM   4320 N NE  . ARG B 1 277 ? 1.64702   -16.10882 -33.84659 1.000 54.22894 ? 279 ARG B NE  1 
ATOM   4321 C CZ  . ARG B 1 277 ? 0.90750   -17.21827 -33.83837 1.000 52.98168 ? 279 ARG B CZ  1 
ATOM   4322 N NH1 . ARG B 1 277 ? 1.40095   -18.36290 -34.30373 1.000 51.95962 ? 279 ARG B NH1 1 
ATOM   4323 N NH2 . ARG B 1 277 ? -0.32926  -17.18591 -33.35477 1.000 49.97518 ? 279 ARG B NH2 1 
ATOM   4324 N N   . THR B 1 278 ? 3.71731   -12.98104 -31.22775 1.000 48.90876 ? 280 THR B N   1 
ATOM   4325 C CA  . THR B 1 278 ? 3.43926   -12.17495 -30.05255 1.000 48.55414 ? 280 THR B CA  1 
ATOM   4326 C C   . THR B 1 278 ? 2.44776   -12.91198 -29.16254 1.000 48.63767 ? 280 THR B C   1 
ATOM   4327 O O   . THR B 1 278 ? 1.72350   -13.80942 -29.60716 1.000 43.94462 ? 280 THR B O   1 
ATOM   4328 C CB  . THR B 1 278 ? 2.86697   -10.79555 -30.41587 1.000 50.23628 ? 280 THR B CB  1 
ATOM   4329 O OG1 . THR B 1 278 ? 1.66707   -10.95828 -31.18565 1.000 51.88947 ? 280 THR B OG1 1 
ATOM   4330 C CG2 . THR B 1 278 ? 3.88268   -9.97860  -31.20313 1.000 49.51084 ? 280 THR B CG2 1 
ATOM   4331 N N   . ILE B 1 279 ? 2.43258   -12.52121 -27.89105 1.000 48.02675 ? 281 ILE B N   1 
ATOM   4332 C CA  . ILE B 1 279 ? 1.46381   -13.00167 -26.91541 1.000 41.47952 ? 281 ILE B CA  1 
ATOM   4333 C C   . ILE B 1 279 ? 0.70465   -11.79258 -26.40647 1.000 44.30202 ? 281 ILE B C   1 
ATOM   4334 O O   . ILE B 1 279 ? 1.31936   -10.80608 -25.98394 1.000 46.17219 ? 281 ILE B O   1 
ATOM   4335 C CB  . ILE B 1 279 ? 2.13753   -13.75095 -25.75568 1.000 38.47684 ? 281 ILE B CB  1 
ATOM   4336 C CG1 . ILE B 1 279 ? 2.90177   -14.95988 -26.28232 1.000 37.71208 ? 281 ILE B CG1 1 
ATOM   4337 C CG2 . ILE B 1 279 ? 1.09699   -14.16010 -24.73115 1.000 40.34398 ? 281 ILE B CG2 1 
ATOM   4338 C CD1 . ILE B 1 279 ? 3.66088   -15.70767 -25.20639 1.000 35.64450 ? 281 ILE B CD1 1 
ATOM   4339 N N   . LEU B 1 280 ? -0.62375  -11.88199 -26.41881 1.000 44.06441 ? 282 LEU B N   1 
ATOM   4340 C CA  . LEU B 1 280 ? -1.45758  -10.69202 -26.36198 1.000 45.65439 ? 282 LEU B CA  1 
ATOM   4341 C C   . LEU B 1 280 ? -0.89067  -9.72252  -27.39527 1.000 52.19282 ? 282 LEU B C   1 
ATOM   4342 O O   . LEU B 1 280 ? -0.74742  -10.08537 -28.56803 1.000 54.71310 ? 282 LEU B O   1 
ATOM   4343 C CB  . LEU B 1 280 ? -1.50942  -10.12248 -24.94138 1.000 43.88595 ? 282 LEU B CB  1 
ATOM   4344 C CG  . LEU B 1 280 ? -2.34477  -11.03568 -24.02990 1.000 42.49036 ? 282 LEU B CG  1 
ATOM   4345 C CD1 . LEU B 1 280 ? -2.31479  -10.61903 -22.56755 1.000 42.28405 ? 282 LEU B CD1 1 
ATOM   4346 C CD2 . LEU B 1 280 ? -3.78226  -11.08621 -24.52365 1.000 40.47583 ? 282 LEU B CD2 1 
ATOM   4347 N N   . GLY B 1 281 ? -0.52055  -8.51777  -27.00129 1.000 49.18227 ? 283 GLY B N   1 
ATOM   4348 C CA  . GLY B 1 281 ? 0.05834   -7.64364  -27.99617 1.000 54.22123 ? 283 GLY B CA  1 
ATOM   4349 C C   . GLY B 1 281 ? 1.56782   -7.64935  -28.09099 1.000 52.17787 ? 283 GLY B C   1 
ATOM   4350 O O   . GLY B 1 281 ? 2.11586   -7.03398  -29.01152 1.000 54.94938 ? 283 GLY B O   1 
ATOM   4351 N N   . SER B 1 282 ? 2.26097   -8.34030  -27.19091 1.000 48.82924 ? 284 SER B N   1 
ATOM   4352 C CA  . SER B 1 282 ? 3.65235   -8.03859  -26.88713 1.000 49.45722 ? 284 SER B CA  1 
ATOM   4353 C C   . SER B 1 282 ? 4.61851   -9.10020  -27.39778 1.000 50.86830 ? 284 SER B C   1 
ATOM   4354 O O   . SER B 1 282 ? 4.31453   -10.29878 -27.39196 1.000 47.67185 ? 284 SER B O   1 
ATOM   4355 C CB  . SER B 1 282 ? 3.84302   -7.87817  -25.37803 1.000 47.13601 ? 284 SER B CB  1 
ATOM   4356 O OG  . SER B 1 282 ? 5.19324   -7.56630  -25.07937 1.000 55.40597 ? 284 SER B OG  1 
ATOM   4357 N N   . ALA B 1 283 ? 5.79400   -8.64022  -27.82744 1.000 48.46337 ? 285 ALA B N   1 
ATOM   4358 C CA  . ALA B 1 283 ? 6.95162   -9.49602  -28.03832 1.000 48.78770 ? 285 ALA B CA  1 
ATOM   4359 C C   . ALA B 1 283 ? 7.69781   -9.78038  -26.74618 1.000 45.85038 ? 285 ALA B C   1 
ATOM   4360 O O   . ALA B 1 283 ? 8.66427   -10.54618 -26.76494 1.000 48.60588 ? 285 ALA B O   1 
ATOM   4361 C CB  . ALA B 1 283 ? 7.90851   -8.86347  -29.05306 1.000 44.45124 ? 285 ALA B CB  1 
ATOM   4362 N N   . LEU B 1 284 ? 7.26854   -9.19995  -25.62970 1.000 47.86614 ? 286 LEU B N   1 
ATOM   4363 C CA  . LEU B 1 284 ? 7.92699   -9.38063  -24.34297 1.000 46.93300 ? 286 LEU B CA  1 
ATOM   4364 C C   . LEU B 1 284 ? 6.95713   -9.99787  -23.34619 1.000 40.96866 ? 286 LEU B C   1 
ATOM   4365 O O   . LEU B 1 284 ? 5.76141   -9.70509  -23.37584 1.000 39.55658 ? 286 LEU B O   1 
ATOM   4366 C CB  . LEU B 1 284 ? 8.45403   -8.04563  -23.79589 1.000 47.42120 ? 286 LEU B CB  1 
ATOM   4367 C CG  . LEU B 1 284 ? 9.63770   -7.40299  -24.53780 1.000 49.12319 ? 286 LEU B CG  1 
ATOM   4368 C CD1 . LEU B 1 284 ? 10.71109  -8.43165  -24.85389 1.000 50.76567 ? 286 LEU B CD1 1 
ATOM   4369 C CD2 . LEU B 1 284 ? 9.20444   -6.69984  -25.79572 1.000 48.06490 ? 286 LEU B CD2 1 
ATOM   4370 N N   . LEU B 1 285 ? 7.48339   -10.85282 -22.47012 1.000 40.43135 ? 287 LEU B N   1 
ATOM   4371 C CA  . LEU B 1 285 ? 6.69227   -11.47703 -21.41412 1.000 35.26371 ? 287 LEU B CA  1 
ATOM   4372 C C   . LEU B 1 285 ? 6.48669   -10.48207 -20.27602 1.000 37.14637 ? 287 LEU B C   1 
ATOM   4373 O O   . LEU B 1 285 ? 7.45400   -9.95372  -19.72114 1.000 42.84226 ? 287 LEU B O   1 
ATOM   4374 C CB  . LEU B 1 285 ? 7.38821   -12.73974 -20.90986 1.000 36.28344 ? 287 LEU B CB  1 
ATOM   4375 C CG  . LEU B 1 285 ? 7.72640   -13.80146 -21.95898 1.000 38.97592 ? 287 LEU B CG  1 
ATOM   4376 C CD1 . LEU B 1 285 ? 8.49174   -14.95894 -21.35745 1.000 35.33873 ? 287 LEU B CD1 1 
ATOM   4377 C CD2 . LEU B 1 285 ? 6.45066   -14.28840 -22.61056 1.000 35.36371 ? 287 LEU B CD2 1 
ATOM   4378 N N   . GLU B 1 286 ? 5.23639   -10.24154 -19.91846 1.000 35.99166 ? 288 GLU B N   1 
ATOM   4379 C CA  . GLU B 1 286 ? 4.88239   -9.24340  -18.91856 1.000 32.48855 ? 288 GLU B CA  1 
ATOM   4380 C C   . GLU B 1 286 ? 4.82598   -9.88327  -17.53295 1.000 33.48790 ? 288 GLU B C   1 
ATOM   4381 O O   . GLU B 1 286 ? 4.26394   -10.97501 -17.36709 1.000 27.45242 ? 288 GLU B O   1 
ATOM   4382 C CB  . GLU B 1 286 ? 3.53012   -8.62641  -19.30452 1.000 35.71371 ? 288 GLU B CB  1 
ATOM   4383 C CG  . GLU B 1 286 ? 2.88515   -7.67652  -18.28500 1.000 39.37766 ? 288 GLU B CG  1 
ATOM   4384 C CD  . GLU B 1 286 ? 3.66072   -6.37635  -18.11920 1.000 44.97184 ? 288 GLU B CD  1 
ATOM   4385 O OE1 . GLU B 1 286 ? 3.94975   -5.70386  -19.13943 1.000 46.07523 ? 288 GLU B OE1 1 
ATOM   4386 O OE2 . GLU B 1 286 ? 3.98568   -6.03390  -16.96106 1.000 44.46964 ? 288 GLU B OE2 1 
ATOM   4387 N N   . ASP B 1 287 ? 5.39537   -9.19986  -16.52321 1.000 27.47355 ? 289 ASP B N   1 
ATOM   4388 C CA  . ASP B 1 287 ? 5.37711   -9.74511  -15.16753 1.000 28.00786 ? 289 ASP B CA  1 
ATOM   4389 C C   . ASP B 1 287 ? 4.77940   -8.78932  -14.13389 1.000 27.81226 ? 289 ASP B C   1 
ATOM   4390 O O   . ASP B 1 287 ? 5.03080   -8.95126  -12.94128 1.000 32.59657 ? 289 ASP B O   1 
ATOM   4391 C CB  . ASP B 1 287 ? 6.78852   -10.19645 -14.73660 1.000 26.61160 ? 289 ASP B CB  1 
ATOM   4392 C CG  . ASP B 1 287 ? 7.71662   -9.04067  -14.36082 1.000 31.11986 ? 289 ASP B CG  1 
ATOM   4393 O OD1 . ASP B 1 287 ? 7.41549   -7.86345  -14.67601 1.000 31.60789 ? 289 ASP B OD1 1 
ATOM   4394 O OD2 . ASP B 1 287 ? 8.78126   -9.32622  -13.74806 1.000 31.07904 ? 289 ASP B OD2 1 
ATOM   4395 N N   . GLU B 1 288 ? 3.98138   -7.80799  -14.53541 1.000 29.99222 ? 290 GLU B N   1 
ATOM   4396 C CA  . GLU B 1 288 ? 3.39181   -6.90379  -13.55504 1.000 33.79548 ? 290 GLU B CA  1 
ATOM   4397 C C   . GLU B 1 288 ? 1.86931   -7.04102  -13.48451 1.000 32.77583 ? 290 GLU B C   1 
ATOM   4398 O O   . GLU B 1 288 ? 1.16627   -6.07919  -13.16322 1.000 31.53899 ? 290 GLU B O   1 
ATOM   4399 C CB  . GLU B 1 288 ? 3.83654   -5.46466  -13.83087 1.000 35.93387 ? 290 GLU B CB  1 
ATOM   4400 C CG  . GLU B 1 288 ? 5.38952   -5.32183  -13.80598 1.000 34.59561 ? 290 GLU B CG  1 
ATOM   4401 C CD  . GLU B 1 288 ? 5.93189   -4.00469  -13.20523 1.000 41.71720 ? 290 GLU B CD  1 
ATOM   4402 O OE1 . GLU B 1 288 ? 5.23423   -2.97053  -13.25852 1.000 35.85260 ? 290 GLU B OE1 1 
ATOM   4403 O OE2 . GLU B 1 288 ? 7.09478   -4.00402  -12.69913 1.000 45.68917 ? 290 GLU B OE2 1 
ATOM   4404 N N   . PHE B 1 289 ? 1.35397   -8.24186  -13.77429 1.000 26.93888 ? 291 PHE B N   1 
ATOM   4405 C CA  . PHE B 1 289 ? -0.00114  -8.65808  -13.42235 1.000 30.41075 ? 291 PHE B CA  1 
ATOM   4406 C C   . PHE B 1 289 ? 0.07806   -9.84071  -12.46763 1.000 29.64818 ? 291 PHE B C   1 
ATOM   4407 O O   . PHE B 1 289 ? 0.66136   -10.87287 -12.81514 1.000 26.23450 ? 291 PHE B O   1 
ATOM   4408 C CB  . PHE B 1 289 ? -0.80532  -9.09308  -14.64956 1.000 31.20362 ? 291 PHE B CB  1 
ATOM   4409 C CG  . PHE B 1 289 ? -1.13797  -7.99613  -15.59319 1.000 33.52113 ? 291 PHE B CG  1 
ATOM   4410 C CD1 . PHE B 1 289 ? -0.31097  -7.72508  -16.66115 1.000 35.47327 ? 291 PHE B CD1 1 
ATOM   4411 C CD2 . PHE B 1 289 ? -2.31113  -7.27342  -15.45244 1.000 40.15425 ? 291 PHE B CD2 1 
ATOM   4412 C CE1 . PHE B 1 289 ? -0.62993  -6.72627  -17.56605 1.000 43.56156 ? 291 PHE B CE1 1 
ATOM   4413 C CE2 . PHE B 1 289 ? -2.63686  -6.27361  -16.35326 1.000 41.34507 ? 291 PHE B CE2 1 
ATOM   4414 C CZ  . PHE B 1 289 ? -1.79546  -6.00243  -17.41024 1.000 39.81613 ? 291 PHE B CZ  1 
ATOM   4415 N N   . THR B 1 290 ? -0.55002  -9.71816  -11.29812 1.000 28.10552 ? 292 THR B N   1 
ATOM   4416 C CA  . THR B 1 290 ? -0.62809  -10.84647 -10.38400 1.000 32.53762 ? 292 THR B CA  1 
ATOM   4417 C C   . THR B 1 290 ? -1.72924  -11.81490 -10.81650 1.000 32.89023 ? 292 THR B C   1 
ATOM   4418 O O   . THR B 1 290 ? -2.59089  -11.47303 -11.63135 1.000 30.45689 ? 292 THR B O   1 
ATOM   4419 C CB  . THR B 1 290 ? -0.90559  -10.37338 -8.95798  1.000 32.90634 ? 292 THR B CB  1 
ATOM   4420 O OG1 . THR B 1 290 ? -2.24070  -9.86941  -8.88115  1.000 32.28784 ? 292 THR B OG1 1 
ATOM   4421 C CG2 . THR B 1 290 ? 0.07480   -9.29309  -8.52681  1.000 30.44062 ? 292 THR B CG2 1 
ATOM   4422 N N   . PRO B 1 291 ? -1.71449  -13.04461 -10.29332 1.000 34.10317 ? 293 PRO B N   1 
ATOM   4423 C CA  . PRO B 1 291 ? -2.88283  -13.92065 -10.47894 1.000 33.90106 ? 293 PRO B CA  1 
ATOM   4424 C C   . PRO B 1 291 ? -4.19551  -13.24243 -10.11607 1.000 37.95703 ? 293 PRO B C   1 
ATOM   4425 O O   . PRO B 1 291 ? -5.18390  -13.36362 -10.85212 1.000 38.18238 ? 293 PRO B O   1 
ATOM   4426 C CB  . PRO B 1 291 ? -2.57305  -15.09463 -9.54589  1.000 33.02230 ? 293 PRO B CB  1 
ATOM   4427 C CG  . PRO B 1 291 ? -1.08155  -15.19273 -9.58622  1.000 37.82508 ? 293 PRO B CG  1 
ATOM   4428 C CD  . PRO B 1 291 ? -0.56941  -13.77124 -9.70587  1.000 36.90035 ? 293 PRO B CD  1 
ATOM   4429 N N   . PHE B 1 292 ? -4.21139  -12.50163 -9.00404  1.000 39.03067 ? 294 PHE B N   1 
ATOM   4430 C CA  . PHE B 1 292 ? -5.41631  -11.79029 -8.57813  1.000 38.96783 ? 294 PHE B CA  1 
ATOM   4431 C C   . PHE B 1 292 ? -5.83672  -10.75521 -9.61546  1.000 40.65019 ? 294 PHE B C   1 
ATOM   4432 O O   . PHE B 1 292 ? -7.01651  -10.66402 -9.97855  1.000 41.24750 ? 294 PHE B O   1 
ATOM   4433 C CB  . PHE B 1 292 ? -5.15715  -11.13333 -7.21812  1.000 42.22732 ? 294 PHE B CB  1 
ATOM   4434 C CG  . PHE B 1 292 ? -6.39935  -10.69172 -6.50270  1.000 49.54977 ? 294 PHE B CG  1 
ATOM   4435 C CD1 . PHE B 1 292 ? -7.01729  -9.48954  -6.83074  1.000 47.40473 ? 294 PHE B CD1 1 
ATOM   4436 C CD2 . PHE B 1 292 ? -6.93668  -11.46459 -5.48316  1.000 48.45556 ? 294 PHE B CD2 1 
ATOM   4437 C CE1 . PHE B 1 292 ? -8.16914  -9.07543  -6.16327  1.000 51.33653 ? 294 PHE B CE1 1 
ATOM   4438 C CE2 . PHE B 1 292 ? -8.09030  -11.05687 -4.81126  1.000 54.63691 ? 294 PHE B CE2 1 
ATOM   4439 C CZ  . PHE B 1 292 ? -8.70590  -9.86379  -5.15401  1.000 47.96251 ? 294 PHE B CZ  1 
ATOM   4440 N N   . ASP B 1 293 ? -4.87836  -9.95289  -10.09756 1.000 33.55890 ? 295 ASP B N   1 
ATOM   4441 C CA  . ASP B 1 293 ? -5.16521  -8.98330  -11.15264 1.000 33.77246 ? 295 ASP B CA  1 
ATOM   4442 C C   . ASP B 1 293 ? -5.83258  -9.65196  -12.34624 1.000 41.45730 ? 295 ASP B C   1 
ATOM   4443 O O   . ASP B 1 293 ? -6.76752  -9.09760  -12.93413 1.000 40.31983 ? 295 ASP B O   1 
ATOM   4444 C CB  . ASP B 1 293 ? -3.87537  -8.29176  -11.62102 1.000 32.31445 ? 295 ASP B CB  1 
ATOM   4445 C CG  . ASP B 1 293 ? -3.16380  -7.51622  -10.50035 1.000 35.51290 ? 295 ASP B CG  1 
ATOM   4446 O OD1 . ASP B 1 293 ? -3.77195  -7.29672  -9.42617  1.000 35.27658 ? 295 ASP B OD1 1 
ATOM   4447 O OD2 . ASP B 1 293 ? -1.98379  -7.12457  -10.70701 1.000 31.51535 ? 295 ASP B OD2 1 
ATOM   4448 N N   . VAL B 1 294 ? -5.34922  -10.84172 -12.72589 1.000 38.78853 ? 296 VAL B N   1 
ATOM   4449 C CA  . VAL B 1 294 ? -5.86626  -11.52624 -13.90769 1.000 39.72205 ? 296 VAL B CA  1 
ATOM   4450 C C   . VAL B 1 294 ? -7.28874  -12.02809 -13.66137 1.000 40.22461 ? 296 VAL B C   1 
ATOM   4451 O O   . VAL B 1 294 ? -8.16024  -11.89118 -14.52442 1.000 40.10636 ? 296 VAL B O   1 
ATOM   4452 C CB  . VAL B 1 294 ? -4.91269  -12.66593 -14.32575 1.000 40.08402 ? 296 VAL B CB  1 
ATOM   4453 C CG1 . VAL B 1 294 ? -5.60862  -13.62510 -15.27410 1.000 39.53935 ? 296 VAL B CG1 1 
ATOM   4454 C CG2 . VAL B 1 294 ? -3.63277  -12.10224 -14.98165 1.000 28.08961 ? 296 VAL B CG2 1 
ATOM   4455 N N   . VAL B 1 295 ? -7.55053  -12.61138 -12.48675 1.000 44.26423 ? 297 VAL B N   1 
ATOM   4456 C CA  . VAL B 1 295 ? -8.90955  -13.06079 -12.17573 1.000 45.25711 ? 297 VAL B CA  1 
ATOM   4457 C C   . VAL B 1 295 ? -9.89167  -11.89337 -12.23892 1.000 50.98264 ? 297 VAL B C   1 
ATOM   4458 O O   . VAL B 1 295 ? -10.99498 -12.01653 -12.78968 1.000 51.20559 ? 297 VAL B O   1 
ATOM   4459 C CB  . VAL B 1 295 ? -8.95575  -13.75492 -10.80172 1.000 48.43792 ? 297 VAL B CB  1 
ATOM   4460 C CG1 . VAL B 1 295 ? -10.38758 -14.14327 -10.46532 1.000 49.89809 ? 297 VAL B CG1 1 
ATOM   4461 C CG2 . VAL B 1 295 ? -8.05704  -14.97870 -10.77818 1.000 44.16315 ? 297 VAL B CG2 1 
ATOM   4462 N N   . ARG B 1 296 ? -9.50692  -10.74510 -11.68721 1.000 46.92700 ? 298 ARG B N   1 
ATOM   4463 C CA  . ARG B 1 296 ? -10.35544 -9.55719  -11.69388 1.000 50.10792 ? 298 ARG B CA  1 
ATOM   4464 C C   . ARG B 1 296 ? -10.09666 -8.68944  -12.92285 1.000 51.50521 ? 298 ARG B C   1 
ATOM   4465 O O   . ARG B 1 296 ? -9.68739  -9.18132  -13.97640 1.000 48.19570 ? 298 ARG B O   1 
ATOM   4466 C CB  . ARG B 1 296 ? -10.13377 -8.73471  -10.41588 1.000 47.65588 ? 298 ARG B CB  1 
HETATM 4467 C C02 . FHR C 2 .   ? 17.19510  10.96281  -2.92683  1.000 56.94331 ? 301 FHR B C02 1 
HETATM 4468 C C07 . FHR C 2 .   ? 22.82012  10.73777  -5.93260  1.000 70.83170 ? 301 FHR B C07 1 
HETATM 4469 C C08 . FHR C 2 .   ? 22.20920  9.56482   -6.60615  1.000 71.45286 ? 301 FHR B C08 1 
HETATM 4470 C C09 . FHR C 2 .   ? 20.79910  9.13833   -6.25595  1.000 63.36398 ? 301 FHR B C09 1 
HETATM 4471 C C10 . FHR C 2 .   ? 19.99333  9.95581   -5.17336  1.000 68.69398 ? 301 FHR B C10 1 
HETATM 4472 C C05 . FHR C 2 .   ? 20.56067  11.05576  -4.54016  1.000 67.95377 ? 301 FHR B C05 1 
HETATM 4473 C C06 . FHR C 2 .   ? 22.03521  11.51041  -4.89867  1.000 67.06893 ? 301 FHR B C06 1 
HETATM 4474 C C04 . FHR C 2 .   ? 19.62887  11.55940  -3.65537  1.000 64.72902 ? 301 FHR B C04 1 
HETATM 4475 C C03 . FHR C 2 .   ? 18.48892  10.77724  -3.75386  1.000 59.91130 ? 301 FHR B C03 1 
HETATM 4476 N N11 . FHR C 2 .   ? 18.71537  9.78492   -4.67781  1.000 61.70263 ? 301 FHR B N11 1 
HETATM 4477 O O01 . FHR C 2 .   ? 16.23124  10.29694  -3.13308  1.000 47.72784 ? 301 FHR B O01 1 
HETATM 4478 N N12 . FHR C 2 .   ? 17.19739  11.97257  -1.86120  1.000 55.09719 ? 301 FHR B N12 1 
HETATM 4479 C C13 . FHR C 2 .   ? 15.99316  12.13411  -1.04598  1.000 49.63877 ? 301 FHR B C13 1 
HETATM 4480 C C21 . FHR C 2 .   ? 15.04145  13.18519  -1.58626  1.000 48.75607 ? 301 FHR B C21 1 
HETATM 4481 O O33 . FHR C 2 .   ? 14.90753  14.21516  -1.05584  1.000 51.47157 ? 301 FHR B O33 1 
HETATM 4482 C C14 . FHR C 2 .   ? 16.43523  12.40428  0.37332   1.000 47.52535 ? 301 FHR B C14 1 
HETATM 4483 C C15 . FHR C 2 .   ? 17.16578  11.09487  0.76000   1.000 47.15457 ? 301 FHR B C15 1 
HETATM 4484 C C20 . FHR C 2 .   ? 18.63622  11.38765  1.07965   1.000 54.80523 ? 301 FHR B C20 1 
HETATM 4485 C C19 . FHR C 2 .   ? 19.40528  10.05799  1.15590   1.000 51.40792 ? 301 FHR B C19 1 
HETATM 4486 C C18 . FHR C 2 .   ? 18.63141  8.96389   1.91100   1.000 50.32280 ? 301 FHR B C18 1 
HETATM 4487 C C17 . FHR C 2 .   ? 17.38860  9.43966   2.69484   1.000 45.76894 ? 301 FHR B C17 1 
HETATM 4488 C C16 . FHR C 2 .   ? 16.46758  10.42423  1.94251   1.000 43.28540 ? 301 FHR B C16 1 
HETATM 4489 O O30 . FHR C 2 .   ? 13.80744  16.32691  -5.91288  1.000 63.77502 ? 301 FHR B O30 1 
HETATM 4490 C C29 . FHR C 2 .   ? 14.47047  15.35027  -5.78012  1.000 60.73218 ? 301 FHR B C29 1 
HETATM 4491 N N28 . FHR C 2 .   ? 16.04919  15.28889  -5.47722  1.000 68.84786 ? 301 FHR B N28 1 
HETATM 4492 C C27 . FHR C 2 .   ? 16.37388  14.02083  -5.41135  1.000 64.69777 ? 301 FHR B C27 1 
HETATM 4493 C C26 . FHR C 2 .   ? 15.03300  13.07951  -5.87540  1.000 62.23719 ? 301 FHR B C26 1 
HETATM 4494 C C25 . FHR C 2 .   ? 13.96930  13.83874  -5.89305  1.000 58.84719 ? 301 FHR B C25 1 
HETATM 4495 C C24 . FHR C 2 .   ? 12.90691  13.43542  -4.73173  1.000 56.15669 ? 301 FHR B C24 1 
HETATM 4496 C C23 . FHR C 2 .   ? 13.32087  13.82081  -3.29736  1.000 50.12035 ? 301 FHR B C23 1 
HETATM 4497 N N22 . FHR C 2 .   ? 14.27596  12.85401  -2.77033  1.000 50.49986 ? 301 FHR B N22 1 
HETATM 4498 C C31 . FHR C 2 .   ? 12.09817  13.71392  -2.41018  1.000 46.64648 ? 301 FHR B C31 1 
HETATM 4499 O O32 . FHR C 2 .   ? 11.10464  14.26928  -2.74417  1.000 45.87609 ? 301 FHR B O32 1 
HETATM 4500 O O   . HOH D 3 .   ? -1.37771  2.01472   -28.19872 1.000 41.61698 ? 301 HOH A O   1 
HETATM 4501 O O   . HOH D 3 .   ? -12.20988 -0.08357  -41.11681 1.000 51.49288 ? 302 HOH A O   1 
HETATM 4502 O O   . HOH D 3 .   ? -37.77899 11.77895  -15.79477 1.000 41.98842 ? 303 HOH A O   1 
HETATM 4503 O O   . HOH D 3 .   ? -40.61359 5.86234   -38.00095 1.000 35.13768 ? 304 HOH A O   1 
HETATM 4504 O O   . HOH D 3 .   ? 13.76173  9.59967   -52.12811 1.000 41.62052 ? 305 HOH A O   1 
HETATM 4505 O O   . HOH D 3 .   ? -28.65032 9.30578   -37.29499 1.000 43.42163 ? 306 HOH A O   1 
HETATM 4506 O O   . HOH D 3 .   ? 3.07802   18.89121  -43.22373 1.000 47.87317 ? 307 HOH A O   1 
HETATM 4507 O O   . HOH D 3 .   ? -33.60476 8.54242   -13.61156 1.000 31.23241 ? 308 HOH A O   1 
HETATM 4508 O O   . HOH D 3 .   ? 2.69160   1.35831   -30.05215 1.000 40.50995 ? 309 HOH A O   1 
HETATM 4509 O O   . HOH D 3 .   ? -22.87656 -1.80314  -20.51118 1.000 47.05144 ? 310 HOH A O   1 
HETATM 4510 O O   . HOH D 3 .   ? 22.84051  16.89891  -35.65943 1.000 42.71689 ? 311 HOH A O   1 
HETATM 4511 O O   . HOH D 3 .   ? 8.97713   -0.22057  -33.72762 1.000 34.71920 ? 312 HOH A O   1 
HETATM 4512 O O   . HOH D 3 .   ? 16.57306  7.53562   -52.59506 1.000 38.07755 ? 313 HOH A O   1 
HETATM 4513 O O   . HOH D 3 .   ? -41.65780 4.89805   -24.26928 1.000 34.21902 ? 314 HOH A O   1 
HETATM 4514 O O   . HOH D 3 .   ? -1.90567  13.17153  -22.50306 1.000 25.69695 ? 315 HOH A O   1 
HETATM 4515 O O   . HOH D 3 .   ? -20.28905 24.70009  -17.68306 1.000 41.41626 ? 316 HOH A O   1 
HETATM 4516 O O   . HOH D 3 .   ? -14.56632 6.83058   -7.87584  1.000 40.69077 ? 317 HOH A O   1 
HETATM 4517 O O   . HOH D 3 .   ? -15.70835 15.59051  -10.09390 1.000 33.46696 ? 318 HOH A O   1 
HETATM 4518 O O   . HOH D 3 .   ? -17.25515 7.77088   -38.97259 1.000 39.39642 ? 319 HOH A O   1 
HETATM 4519 O O   . HOH D 3 .   ? 1.82703   11.18535  -41.31641 1.000 38.54887 ? 320 HOH A O   1 
HETATM 4520 O O   . HOH D 3 .   ? 18.18659  -0.86634  -43.09522 1.000 29.72787 ? 321 HOH A O   1 
HETATM 4521 O O   . HOH D 3 .   ? 1.33149   15.92635  -21.20419 1.000 46.11723 ? 322 HOH A O   1 
HETATM 4522 O O   . HOH D 3 .   ? 17.82870  5.62619   -46.79074 1.000 32.38606 ? 323 HOH A O   1 
HETATM 4523 O O   . HOH D 3 .   ? 1.39083   16.13766  -40.38841 1.000 40.25099 ? 324 HOH A O   1 
HETATM 4524 O O   . HOH D 3 .   ? 17.248    -6.814    -28.022   1.000 49.24355 ? 325 HOH A O   1 
HETATM 4525 O O   . HOH D 3 .   ? -36.22020 11.23640  -32.94847 1.000 35.33560 ? 326 HOH A O   1 
HETATM 4526 O O   . HOH D 3 .   ? -4.09141  3.01533   -27.96248 1.000 32.16875 ? 327 HOH A O   1 
HETATM 4527 O O   . HOH D 3 .   ? -31.68980 21.17600  -15.30634 1.000 40.74698 ? 328 HOH A O   1 
HETATM 4528 O O   . HOH D 3 .   ? 19.09063  15.53419  -44.87173 1.000 40.95474 ? 329 HOH A O   1 
HETATM 4529 O O   . HOH D 3 .   ? 24.26073  11.75369  -37.23421 1.000 40.42321 ? 330 HOH A O   1 
HETATM 4530 O O   . HOH D 3 .   ? -11.60289 21.76391  -12.04584 1.000 31.67537 ? 331 HOH A O   1 
HETATM 4531 O O   . HOH D 3 .   ? -34.24573 -1.58463  -37.82568 1.000 45.01852 ? 332 HOH A O   1 
HETATM 4532 O O   . HOH D 3 .   ? -35.79228 1.08983   -27.91440 1.000 35.22826 ? 333 HOH A O   1 
HETATM 4533 O O   . HOH D 3 .   ? -28.13671 2.28418   -38.41292 1.000 35.22244 ? 334 HOH A O   1 
HETATM 4534 O O   . HOH D 3 .   ? -30.42766 -6.47389  -33.94543 1.000 41.50667 ? 335 HOH A O   1 
HETATM 4535 O O   . HOH D 3 .   ? -14.93878 15.97070  -27.42308 1.000 31.48258 ? 336 HOH A O   1 
HETATM 4536 O O   . HOH D 3 .   ? -0.13074  15.62090  -26.21370 1.000 35.22324 ? 337 HOH A O   1 
HETATM 4537 O O   . HOH D 3 .   ? -26.18651 -1.01354  -26.15022 1.000 38.14830 ? 338 HOH A O   1 
HETATM 4538 O O   . HOH D 3 .   ? 20.77291  5.65547   -40.44561 1.000 27.96352 ? 339 HOH A O   1 
HETATM 4539 O O   . HOH D 3 .   ? 13.61113  6.57533   -17.28671 1.000 57.47199 ? 340 HOH A O   1 
HETATM 4540 O O   . HOH D 3 .   ? -4.18981  8.27625   -39.18192 1.000 37.63361 ? 341 HOH A O   1 
HETATM 4541 O O   . HOH D 3 .   ? -36.59455 -1.13360  -29.74801 1.000 51.45196 ? 342 HOH A O   1 
HETATM 4542 O O   . HOH D 3 .   ? -35.32618 0.29829   -25.01074 1.000 40.84728 ? 343 HOH A O   1 
HETATM 4543 O O   . HOH D 3 .   ? 12.44733  -3.62354  -36.54176 1.000 32.94963 ? 344 HOH A O   1 
HETATM 4544 O O   . HOH D 3 .   ? 4.76325   20.77047  -23.59693 1.000 45.78988 ? 345 HOH A O   1 
HETATM 4545 O O   . HOH D 3 .   ? -21.72069 15.71251  -37.55542 1.000 46.17715 ? 346 HOH A O   1 
HETATM 4546 O O   . HOH D 3 .   ? 3.38294   0.94438   -44.33095 1.000 41.08447 ? 347 HOH A O   1 
HETATM 4547 O O   . HOH D 3 .   ? 21.56772  2.78907   -33.41465 1.000 33.91642 ? 348 HOH A O   1 
HETATM 4548 O O   . HOH D 3 .   ? 16.48859  -5.13395  -25.34243 1.000 45.13085 ? 349 HOH A O   1 
HETATM 4549 O O   . HOH D 3 .   ? 10.03909  -1.62939  -30.48082 1.000 36.12877 ? 350 HOH A O   1 
HETATM 4550 O O   . HOH D 3 .   ? -31.57347 -3.89130  -36.25389 1.000 38.32293 ? 351 HOH A O   1 
HETATM 4551 O O   . HOH D 3 .   ? -38.44645 11.57691  -27.96375 1.000 37.03476 ? 352 HOH A O   1 
HETATM 4552 O O   . HOH D 3 .   ? -12.96828 5.43320   -32.84735 1.000 24.89981 ? 353 HOH A O   1 
HETATM 4553 O O   . HOH D 3 .   ? 21.02180  -1.95465  -31.74669 1.000 38.34076 ? 354 HOH A O   1 
HETATM 4554 O O   . HOH D 3 .   ? -4.24474  16.64760  -28.07941 1.000 40.85200 ? 355 HOH A O   1 
HETATM 4555 O O   . HOH D 3 .   ? 26.10990  3.15069   -38.21155 1.000 39.86290 ? 356 HOH A O   1 
HETATM 4556 O O   . HOH D 3 .   ? -5.92790  -2.80069  -43.18674 1.000 55.36092 ? 357 HOH A O   1 
HETATM 4557 O O   . HOH D 3 .   ? -27.90211 12.05944  -34.66649 1.000 31.24112 ? 358 HOH A O   1 
HETATM 4558 O O   . HOH D 3 .   ? 5.39871   -0.85467  -36.78689 1.000 34.95534 ? 359 HOH A O   1 
HETATM 4559 O O   . HOH D 3 .   ? -29.24964 3.44935   -14.47122 1.000 35.27263 ? 360 HOH A O   1 
HETATM 4560 O O   . HOH D 3 .   ? 15.83409  -4.52615  -41.63200 1.000 35.96123 ? 361 HOH A O   1 
HETATM 4561 O O   . HOH D 3 .   ? -18.20903 7.43464   -9.69560  1.000 44.00801 ? 362 HOH A O   1 
HETATM 4562 O O   . HOH D 3 .   ? -20.04248 10.09761  -36.30782 1.000 30.78554 ? 363 HOH A O   1 
HETATM 4563 O O   . HOH D 3 .   ? -9.07432  17.38190  -7.77615  1.000 46.78401 ? 364 HOH A O   1 
HETATM 4564 O O   . HOH D 3 .   ? -7.14624  19.87025  -20.55425 1.000 36.84816 ? 365 HOH A O   1 
HETATM 4565 O O   . HOH D 3 .   ? 6.44923   8.03622   -27.73831 1.000 27.71456 ? 366 HOH A O   1 
HETATM 4566 O O   . HOH D 3 .   ? -25.37732 -5.07557  -39.81903 1.000 36.73669 ? 367 HOH A O   1 
HETATM 4567 O O   . HOH D 3 .   ? -0.82441  19.43549  -17.88898 1.000 44.74803 ? 368 HOH A O   1 
HETATM 4568 O O   . HOH D 3 .   ? -6.83217  18.02408  -30.28291 1.000 41.37580 ? 369 HOH A O   1 
HETATM 4569 O O   . HOH D 3 .   ? -9.48002  2.17120   -39.24429 1.000 39.26607 ? 370 HOH A O   1 
HETATM 4570 O O   . HOH D 3 .   ? -17.86491 1.44019   -40.75619 1.000 40.14349 ? 371 HOH A O   1 
HETATM 4571 O O   . HOH D 3 .   ? -30.86125 17.21761  -23.85595 1.000 35.66422 ? 372 HOH A O   1 
HETATM 4572 O O   . HOH D 3 .   ? 18.98588  9.95204   -47.46939 1.000 33.62499 ? 373 HOH A O   1 
HETATM 4573 O O   . HOH D 3 .   ? 1.64039   13.29221  -32.04739 1.000 29.88167 ? 374 HOH A O   1 
HETATM 4574 O O   . HOH D 3 .   ? 15.78004  11.72906  -51.29379 1.000 35.76177 ? 375 HOH A O   1 
HETATM 4575 O O   . HOH D 3 .   ? -12.32840 10.53545  -38.10256 1.000 35.11291 ? 376 HOH A O   1 
HETATM 4576 O O   . HOH D 3 .   ? -16.92451 11.58061  -37.72026 1.000 36.55781 ? 377 HOH A O   1 
HETATM 4577 O O   . HOH D 3 .   ? -20.14534 24.76797  -15.05500 1.000 49.57762 ? 378 HOH A O   1 
HETATM 4578 O O   . HOH D 3 .   ? 11.997    1.224     -52.116   1.000 41.76206 ? 379 HOH A O   1 
HETATM 4579 O O   . HOH D 3 .   ? 15.17005  -5.33956  -30.02532 1.000 44.05508 ? 380 HOH A O   1 
HETATM 4580 O O   . HOH D 3 .   ? 16.36896  19.68279  -37.57426 1.000 41.89978 ? 381 HOH A O   1 
HETATM 4581 O O   . HOH D 3 .   ? -24.00759 4.90114   -29.95028 1.000 25.31810 ? 382 HOH A O   1 
HETATM 4582 O O   . HOH D 3 .   ? 18.35331  -6.46688  -31.57057 1.000 40.68993 ? 383 HOH A O   1 
HETATM 4583 O O   . HOH D 3 .   ? -32.69283 14.96435  -30.68617 1.000 36.38574 ? 384 HOH A O   1 
HETATM 4584 O O   . HOH D 3 .   ? 3.12835   3.22991   -43.38414 1.000 43.32398 ? 385 HOH A O   1 
HETATM 4585 O O   . HOH D 3 .   ? -32.78715 0.11455   -24.76801 1.000 33.96137 ? 386 HOH A O   1 
HETATM 4586 O O   . HOH D 3 .   ? -22.17719 17.70658  -26.75076 1.000 32.91449 ? 387 HOH A O   1 
HETATM 4587 O O   . HOH D 3 .   ? 15.07820  16.10400  -46.73695 1.000 37.53895 ? 388 HOH A O   1 
HETATM 4588 O O   . HOH D 3 .   ? -22.86875 19.93584  -19.68199 1.000 34.11704 ? 389 HOH A O   1 
HETATM 4589 O O   . HOH D 3 .   ? 6.43620   14.09603  -45.86532 1.000 48.57570 ? 390 HOH A O   1 
HETATM 4590 O O   . HOH D 3 .   ? -10.87114 6.43188   -6.20240  1.000 31.29810 ? 391 HOH A O   1 
HETATM 4591 O O   . HOH D 3 .   ? -0.96815  11.80142  -17.98918 1.000 35.40769 ? 392 HOH A O   1 
HETATM 4592 O O   . HOH D 3 .   ? -6.80928  16.78890  -11.17980 1.000 39.02677 ? 393 HOH A O   1 
HETATM 4593 O O   . HOH D 3 .   ? 1.45019   9.87627   -22.72622 1.000 34.47655 ? 394 HOH A O   1 
HETATM 4594 O O   . HOH D 3 .   ? -21.99022 14.34470  -7.53053  1.000 39.01021 ? 395 HOH A O   1 
HETATM 4595 O O   . HOH D 3 .   ? 18.167    10.558    -51.837   1.000 39.10038 ? 396 HOH A O   1 
HETATM 4596 O O   . HOH D 3 .   ? 21.61708  1.18733   -43.14048 1.000 28.84319 ? 397 HOH A O   1 
HETATM 4597 O O   . HOH D 3 .   ? 4.03399   2.39352   -27.53939 1.000 37.62734 ? 398 HOH A O   1 
HETATM 4598 O O   . HOH D 3 .   ? -23.78484 1.90542   -41.55477 1.000 43.65784 ? 399 HOH A O   1 
HETATM 4599 O O   . HOH D 3 .   ? -15.20239 7.39463   -17.75754 1.000 26.63108 ? 400 HOH A O   1 
HETATM 4600 O O   . HOH D 3 .   ? 16.05546  0.28533   -41.59392 1.000 25.13673 ? 401 HOH A O   1 
HETATM 4601 O O   . HOH D 3 .   ? -29.10213 0.14921   -42.26909 1.000 31.47508 ? 402 HOH A O   1 
HETATM 4602 O O   . HOH D 3 .   ? 14.30872  24.23202  -27.04572 1.000 53.54877 ? 403 HOH A O   1 
HETATM 4603 O O   . HOH D 3 .   ? -28.07408 22.48928  -20.08012 1.000 53.19610 ? 404 HOH A O   1 
HETATM 4604 O O   . HOH D 3 .   ? -19.12105 -3.74987  -29.10882 1.000 41.52183 ? 405 HOH A O   1 
HETATM 4605 O O   . HOH D 3 .   ? 20.454    -6.946    -35.354   1.000 39.91607 ? 406 HOH A O   1 
HETATM 4606 O O   . HOH D 3 .   ? -8.35665  15.97421  -24.11042 1.000 31.20176 ? 407 HOH A O   1 
HETATM 4607 O O   . HOH D 3 .   ? -11.55827 20.60706  -30.46273 1.000 43.95487 ? 408 HOH A O   1 
HETATM 4608 O O   . HOH D 3 .   ? 13.17823  14.62433  -49.02736 1.000 33.38571 ? 409 HOH A O   1 
HETATM 4609 O O   . HOH D 3 .   ? 19.34839  6.63432   -48.87920 1.000 29.57811 ? 410 HOH A O   1 
HETATM 4610 O O   . HOH D 3 .   ? -35.77763 9.81716   -15.14463 1.000 39.93273 ? 411 HOH A O   1 
HETATM 4611 O O   . HOH D 3 .   ? -6.15662  -1.41110  -33.76330 1.000 41.01039 ? 412 HOH A O   1 
HETATM 4612 O O   . HOH D 3 .   ? -22.84004 6.37927   -36.72146 1.000 32.31154 ? 413 HOH A O   1 
HETATM 4613 O O   . HOH D 3 .   ? 4.19719   10.60716  -37.40289 1.000 28.37219 ? 414 HOH A O   1 
HETATM 4614 O O   . HOH D 3 .   ? 22.13215  9.97750   -35.67077 1.000 37.48672 ? 415 HOH A O   1 
HETATM 4615 O O   . HOH D 3 .   ? -6.54736  5.57776   -40.72367 1.000 43.28628 ? 416 HOH A O   1 
HETATM 4616 O O   . HOH D 3 .   ? -20.59186 18.43951  -33.97210 1.000 49.06890 ? 417 HOH A O   1 
HETATM 4617 O O   . HOH D 3 .   ? 8.30723   12.22927  -48.03599 1.000 37.26204 ? 418 HOH A O   1 
HETATM 4618 O O   . HOH D 3 .   ? -27.11355 15.80352  -34.62210 1.000 40.16902 ? 419 HOH A O   1 
HETATM 4619 O O   . HOH D 3 .   ? -15.94922 23.07384  -24.84665 1.000 41.12301 ? 420 HOH A O   1 
HETATM 4620 O O   . HOH D 3 .   ? 9.72365   5.32796   -21.56035 1.000 48.09433 ? 421 HOH A O   1 
HETATM 4621 O O   . HOH D 3 .   ? 20.05848  7.02375   -42.70033 1.000 30.40576 ? 422 HOH A O   1 
HETATM 4622 O O   . HOH D 3 .   ? -24.14351 12.46920  -37.63421 1.000 45.19070 ? 423 HOH A O   1 
HETATM 4623 O O   . HOH D 3 .   ? -9.61844  13.02031  -35.66692 1.000 41.41522 ? 424 HOH A O   1 
HETATM 4624 O O   . HOH D 3 .   ? -20.47256 7.56116   -37.54652 1.000 36.28610 ? 425 HOH A O   1 
HETATM 4625 O O   . HOH D 3 .   ? 12.71931  21.55924  -37.23440 1.000 47.26943 ? 426 HOH A O   1 
HETATM 4626 O O   . HOH D 3 .   ? -25.59985 3.60827   -37.09240 1.000 34.62523 ? 427 HOH A O   1 
HETATM 4627 O O   . HOH D 3 .   ? -3.57381  3.36280   -40.50571 1.000 49.73562 ? 428 HOH A O   1 
HETATM 4628 O O   . HOH D 3 .   ? 20.09553  8.09253   -45.58566 1.000 35.54597 ? 429 HOH A O   1 
HETATM 4629 O O   . HOH D 3 .   ? -36.95091 16.37100  -24.47388 1.000 38.18364 ? 430 HOH A O   1 
HETATM 4630 O O   . HOH D 3 .   ? 22.43955  17.08905  -40.69334 1.000 47.13124 ? 431 HOH A O   1 
HETATM 4631 O O   . HOH D 3 .   ? -20.36026 22.89927  -6.15695  1.000 47.26864 ? 432 HOH A O   1 
HETATM 4632 O O   . HOH D 3 .   ? -40.90013 12.98260  -22.18904 1.000 42.80896 ? 433 HOH A O   1 
HETATM 4633 O O   . HOH D 3 .   ? 23.52751  -4.65957  -34.53475 1.000 39.73210 ? 434 HOH A O   1 
HETATM 4634 O O   . HOH D 3 .   ? -23.20847 5.58283   -10.47896 1.000 43.08748 ? 435 HOH A O   1 
HETATM 4635 O O   . HOH D 3 .   ? 11.89023  23.31192  -38.82734 1.000 53.36860 ? 436 HOH A O   1 
HETATM 4636 O O   . HOH D 3 .   ? -30.17629 5.90973   -37.65747 1.000 30.12305 ? 437 HOH A O   1 
HETATM 4637 O O   . HOH D 3 .   ? -33.28511 14.30274  -9.23007  1.000 47.64503 ? 438 HOH A O   1 
HETATM 4638 O O   . HOH D 3 .   ? -34.27938 0.23554   -35.11485 1.000 35.30399 ? 439 HOH A O   1 
HETATM 4639 O O   . HOH D 3 .   ? -28.82703 22.32832  -9.51897  1.000 40.11778 ? 440 HOH A O   1 
HETATM 4640 O O   . HOH D 3 .   ? -29.52395 14.54570  -34.17795 1.000 47.65252 ? 441 HOH A O   1 
HETATM 4641 O O   . HOH D 3 .   ? -1.18007  21.14737  -15.88628 1.000 44.18780 ? 442 HOH A O   1 
HETATM 4642 O O   . HOH D 3 .   ? -16.20278 24.59214  -17.08983 1.000 34.64771 ? 443 HOH A O   1 
HETATM 4643 O O   . HOH D 3 .   ? -14.44288 14.62768  -7.71151  1.000 41.41215 ? 444 HOH A O   1 
HETATM 4644 O O   . HOH D 3 .   ? 11.85526  -3.61254  -29.82087 1.000 50.55066 ? 445 HOH A O   1 
HETATM 4645 O O   . HOH D 3 .   ? -1.26581  3.81021   -17.83673 1.000 37.54252 ? 446 HOH A O   1 
HETATM 4646 O O   . HOH D 3 .   ? 16.64175  18.20570  -39.83116 1.000 37.00774 ? 447 HOH A O   1 
HETATM 4647 O O   . HOH D 3 .   ? 24.34810  9.98597   -44.12567 1.000 35.12023 ? 448 HOH A O   1 
HETATM 4648 O O   . HOH D 3 .   ? 11.46163  17.89480  -20.55602 1.000 53.42330 ? 449 HOH A O   1 
HETATM 4649 O O   . HOH D 3 .   ? 2.45345   17.07785  -29.76681 1.000 35.12935 ? 450 HOH A O   1 
HETATM 4650 O O   . HOH D 3 .   ? -7.94164  -1.89755  -11.97175 1.000 42.79755 ? 451 HOH A O   1 
HETATM 4651 O O   . HOH D 3 .   ? -20.94127 -1.83984  -23.02834 1.000 42.23198 ? 452 HOH A O   1 
HETATM 4652 O O   . HOH D 3 .   ? -11.10123 13.28548  -37.71459 1.000 47.58225 ? 453 HOH A O   1 
HETATM 4653 O O   . HOH D 3 .   ? -35.40442 14.20811  -28.86060 1.000 35.37883 ? 454 HOH A O   1 
HETATM 4654 O O   . HOH D 3 .   ? 18.33832  4.92169   -19.00053 1.000 52.90052 ? 455 HOH A O   1 
HETATM 4655 O O   . HOH D 3 .   ? 13.04880  19.43449  -20.93760 1.000 56.80352 ? 456 HOH A O   1 
HETATM 4656 O O   . HOH D 3 .   ? 0.94668   18.15156  -42.10642 1.000 51.89179 ? 457 HOH A O   1 
HETATM 4657 O O   . HOH D 3 .   ? 21.90727  0.16783   -33.16201 1.000 34.89571 ? 458 HOH A O   1 
HETATM 4658 O O   . HOH D 3 .   ? -0.07498  13.22969  -20.63195 1.000 32.16911 ? 459 HOH A O   1 
HETATM 4659 O O   . HOH D 3 .   ? -23.97050 -4.66527  -41.58770 1.000 43.30681 ? 460 HOH A O   1 
HETATM 4660 O O   . HOH D 3 .   ? 12.20434  15.34529  -21.37155 1.000 41.69090 ? 461 HOH A O   1 
HETATM 4661 O O   . HOH D 3 .   ? -14.59263 12.07906  -6.72982  1.000 48.04589 ? 462 HOH A O   1 
HETATM 4662 O O   . HOH D 3 .   ? -31.85983 1.92852   -40.49001 1.000 44.15541 ? 463 HOH A O   1 
HETATM 4663 O O   . HOH D 3 .   ? -21.49619 -3.96899  -23.51861 1.000 54.64633 ? 464 HOH A O   1 
HETATM 4664 O O   . HOH D 3 .   ? -33.36831 19.63879  -7.73073  1.000 52.60185 ? 465 HOH A O   1 
HETATM 4665 O O   . HOH D 3 .   ? -32.05532 14.42541  -7.32757  1.000 51.73536 ? 466 HOH A O   1 
HETATM 4666 O O   . HOH D 3 .   ? 10.97048  19.28709  -18.91519 1.000 60.10869 ? 467 HOH A O   1 
HETATM 4667 O O   . HOH D 3 .   ? 24.37625  -0.50049  -32.90683 1.000 41.58254 ? 468 HOH A O   1 
HETATM 4668 O O   . HOH D 3 .   ? -29.46137 1.79585   -40.81436 1.000 46.94066 ? 469 HOH A O   1 
HETATM 4669 O O   . HOH D 3 .   ? -15.64222 18.39109  -29.21260 1.000 39.57137 ? 470 HOH A O   1 
HETATM 4670 O O   . HOH D 3 .   ? -12.829   14.658    -38.824   1.000 55.95943 ? 471 HOH A O   1 
HETATM 4671 O O   . HOH D 3 .   ? -15.979   16.064    -37.039   1.000 46.49007 ? 472 HOH A O   1 
HETATM 4672 O O   . HOH D 3 .   ? 0.13240   13.98719  -40.73293 1.000 48.19022 ? 473 HOH A O   1 
HETATM 4673 O O   . HOH D 3 .   ? 0.37501   15.33023  -30.69798 1.000 42.67608 ? 474 HOH A O   1 
HETATM 4674 O O   . HOH D 3 .   ? 26.32311  13.44271  -37.20691 1.000 44.37578 ? 475 HOH A O   1 
HETATM 4675 O O   . HOH D 3 .   ? 17.45880  2.91784   -17.56161 1.000 49.86798 ? 476 HOH A O   1 
HETATM 4676 O O   . HOH D 3 .   ? 20.88879  2.86408   -40.99783 1.000 33.33172 ? 477 HOH A O   1 
HETATM 4677 O O   . HOH D 3 .   ? -24.72945 10.49234  -36.81479 1.000 47.10070 ? 478 HOH A O   1 
HETATM 4678 O O   . HOH D 3 .   ? -36.93951 12.85980  -30.64868 1.000 41.87710 ? 479 HOH A O   1 
HETATM 4679 O O   . HOH D 3 .   ? -20.97282 -6.29171  -23.44655 1.000 66.49893 ? 480 HOH A O   1 
HETATM 4680 O O   . HOH D 3 .   ? -24.72019 5.57450   -38.65712 1.000 44.40173 ? 481 HOH A O   1 
HETATM 4681 O O   . HOH D 3 .   ? -29.74058 19.12361  -23.79212 1.000 48.97575 ? 482 HOH A O   1 
HETATM 4682 O O   . HOH D 3 .   ? 17.46494  16.60833  -46.60250 1.000 42.77707 ? 483 HOH A O   1 
HETATM 4683 O O   . HOH D 3 .   ? -31.29374 20.52351  -6.41801  1.000 51.95865 ? 484 HOH A O   1 
HETATM 4684 O O   . HOH D 3 .   ? 14.137    -6.286    -35.556   1.000 47.68658 ? 485 HOH A O   1 
HETATM 4685 O O   . HOH D 3 .   ? -9.24553  4.23236   -41.04210 1.000 46.58515 ? 486 HOH A O   1 
HETATM 4686 O O   . HOH D 3 .   ? 10.23787  15.57191  -48.78015 1.000 51.38718 ? 487 HOH A O   1 
HETATM 4687 O O   . HOH D 3 .   ? 21.15656  11.56827  -48.24554 1.000 40.29746 ? 488 HOH A O   1 
HETATM 4688 O O   . HOH D 3 .   ? -27.05934 -4.07004  -26.06742 1.000 55.50425 ? 489 HOH A O   1 
HETATM 4689 O O   . HOH D 3 .   ? -20.04466 4.28117   -43.25244 1.000 52.60232 ? 490 HOH A O   1 
HETATM 4690 O O   . HOH D 3 .   ? 15.80406  5.91649   -17.28783 1.000 50.95848 ? 491 HOH A O   1 
HETATM 4691 O O   . HOH D 3 .   ? 10.913    6.887     -54.745   1.000 47.18009 ? 492 HOH A O   1 
HETATM 4692 O O   . HOH D 3 .   ? 20.429    11.956    -51.407   1.000 47.45214 ? 493 HOH A O   1 
HETATM 4693 O O   . HOH D 3 .   ? -21.12744 1.97548   -42.82266 1.000 51.74776 ? 494 HOH A O   1 
HETATM 4694 O O   . HOH D 3 .   ? -24.37798 14.50514  -5.77218  1.000 47.69067 ? 495 HOH A O   1 
HETATM 4695 O O   . HOH E 3 .   ? -9.25566  -7.77899  -15.61075 1.000 48.96961 ? 401 HOH B O   1 
HETATM 4696 O O   . HOH E 3 .   ? -0.80591  -11.70902 -30.15183 1.000 49.47456 ? 402 HOH B O   1 
HETATM 4697 O O   . HOH E 3 .   ? 13.49890  15.49203  0.30431   1.000 45.30233 ? 403 HOH B O   1 
HETATM 4698 O O   . HOH E 3 .   ? 0.95582   24.02411  9.28171   1.000 41.43916 ? 404 HOH B O   1 
HETATM 4699 O O   . HOH E 3 .   ? -10.71429 -10.59704 -15.75087 1.000 48.49741 ? 405 HOH B O   1 
HETATM 4700 O O   . HOH E 3 .   ? -8.64751  -2.57162  0.35704   1.000 36.42988 ? 406 HOH B O   1 
HETATM 4701 O O   . HOH E 3 .   ? 10.77506  -1.17990  11.39153  1.000 26.79499 ? 407 HOH B O   1 
HETATM 4702 O O   . HOH E 3 .   ? -10.41016 -18.49438 -12.82090 1.000 52.49704 ? 408 HOH B O   1 
HETATM 4703 O O   . HOH E 3 .   ? 8.28396   -12.17183 -31.43207 1.000 48.74093 ? 409 HOH B O   1 
HETATM 4704 O O   . HOH E 3 .   ? 12.53174  -17.55383 -31.19139 1.000 47.94827 ? 410 HOH B O   1 
HETATM 4705 O O   . HOH E 3 .   ? 1.41849   -25.82543 -22.76134 1.000 40.26003 ? 411 HOH B O   1 
HETATM 4706 O O   . HOH E 3 .   ? -1.44631  -5.18085  -12.25778 1.000 30.13222 ? 412 HOH B O   1 
HETATM 4707 O O   . HOH E 3 .   ? -7.11958  16.89976  15.96925  1.000 45.52672 ? 413 HOH B O   1 
HETATM 4708 O O   . HOH E 3 .   ? 13.55782  -34.64279 -13.84462 1.000 48.78123 ? 414 HOH B O   1 
HETATM 4709 O O   . HOH E 3 .   ? -10.56896 11.12970  -0.76302  1.000 35.06351 ? 415 HOH B O   1 
HETATM 4710 O O   . HOH E 3 .   ? 7.93215   -1.82247  -10.38986 1.000 35.04795 ? 416 HOH B O   1 
HETATM 4711 O O   . HOH E 3 .   ? 1.24883   -1.68931  7.13504   1.000 34.85968 ? 417 HOH B O   1 
HETATM 4712 O O   . HOH E 3 .   ? -3.81572  17.05060  -9.43166  1.000 45.46809 ? 418 HOH B O   1 
HETATM 4713 O O   . HOH E 3 .   ? 17.57473  -4.27563  -3.91887  1.000 32.04343 ? 419 HOH B O   1 
HETATM 4714 O O   . HOH E 3 .   ? 13.83964  -4.21334  -12.11022 1.000 47.15131 ? 420 HOH B O   1 
HETATM 4715 O O   . HOH E 3 .   ? 15.27951  -16.39345 -22.74577 1.000 48.73615 ? 421 HOH B O   1 
HETATM 4716 O O   . HOH E 3 .   ? 10.81639  -17.83504 -5.24704  1.000 48.64960 ? 422 HOH B O   1 
HETATM 4717 O O   . HOH E 3 .   ? 7.14122   -7.66827  2.20566   1.000 38.11056 ? 423 HOH B O   1 
HETATM 4718 O O   . HOH E 3 .   ? -2.79461  -25.02812 -8.70326  1.000 53.60948 ? 424 HOH B O   1 
HETATM 4719 O O   . HOH E 3 .   ? -2.92935  -8.04280  -7.06487  1.000 41.16064 ? 425 HOH B O   1 
HETATM 4720 O O   . HOH E 3 .   ? 12.27665  20.37691  -0.73052  1.000 47.08974 ? 426 HOH B O   1 
HETATM 4721 O O   . HOH E 3 .   ? -2.66744  -29.10710 -18.71573 1.000 45.91138 ? 427 HOH B O   1 
HETATM 4722 O O   . HOH E 3 .   ? 16.17023  -1.02262  6.29791   1.000 33.29544 ? 428 HOH B O   1 
HETATM 4723 O O   . HOH E 3 .   ? 9.14678   -32.68283 -17.89334 1.000 44.00027 ? 429 HOH B O   1 
HETATM 4724 O O   . HOH E 3 .   ? 3.59830   -3.25288  8.23472   1.000 33.93377 ? 430 HOH B O   1 
HETATM 4725 O O   . HOH E 3 .   ? -8.35502  14.46479  -10.76926 1.000 27.93568 ? 431 HOH B O   1 
HETATM 4726 O O   . HOH E 3 .   ? -1.85113  5.83952   12.74296  1.000 32.12325 ? 432 HOH B O   1 
HETATM 4727 O O   . HOH E 3 .   ? -4.84497  8.78727   10.51760  1.000 28.75546 ? 433 HOH B O   1 
HETATM 4728 O O   . HOH E 3 .   ? 11.65283  -0.11103  -1.29461  1.000 27.99200 ? 434 HOH B O   1 
HETATM 4729 O O   . HOH E 3 .   ? 14.99142  -3.28880  5.45656   1.000 34.10245 ? 435 HOH B O   1 
HETATM 4730 O O   . HOH E 3 .   ? 2.05665   4.99222   10.75847  1.000 33.80250 ? 436 HOH B O   1 
HETATM 4731 O O   . HOH E 3 .   ? 23.97154  12.54660  14.69606  1.000 53.42645 ? 437 HOH B O   1 
HETATM 4732 O O   . HOH E 3 .   ? -9.77061  17.52263  2.34003   1.000 41.65253 ? 438 HOH B O   1 
HETATM 4733 O O   . HOH E 3 .   ? -2.46162  -12.62599 -6.94919  1.000 42.90371 ? 439 HOH B O   1 
HETATM 4734 O O   . HOH E 3 .   ? -16.31335 0.67420   1.12821   1.000 51.37824 ? 440 HOH B O   1 
HETATM 4735 O O   . HOH E 3 .   ? -5.37307  -1.66649  -10.93429 1.000 30.13709 ? 441 HOH B O   1 
HETATM 4736 O O   . HOH E 3 .   ? -1.37251  -27.55240 -23.23875 1.000 39.66856 ? 442 HOH B O   1 
HETATM 4737 O O   . HOH E 3 .   ? -2.96382  -4.28213  -8.07150  1.000 27.73346 ? 443 HOH B O   1 
HETATM 4738 O O   . HOH E 3 .   ? 4.81698   -12.56570 -5.74048  1.000 43.08822 ? 444 HOH B O   1 
HETATM 4739 O O   . HOH E 3 .   ? 2.80004   -11.88909 -7.40602  1.000 31.16286 ? 445 HOH B O   1 
HETATM 4740 O O   . HOH E 3 .   ? 14.59715  15.38011  3.21557   1.000 44.70267 ? 446 HOH B O   1 
HETATM 4741 O O   . HOH E 3 .   ? 20.75408  -3.72527  -2.26342  1.000 44.77822 ? 447 HOH B O   1 
HETATM 4742 O O   . HOH E 3 .   ? 4.17351   22.95267  3.27282   1.000 42.18507 ? 448 HOH B O   1 
HETATM 4743 O O   . HOH E 3 .   ? 0.47542   9.84237   -3.39180  1.000 30.15259 ? 449 HOH B O   1 
HETATM 4744 O O   . HOH E 3 .   ? 17.32200  -0.78131  -10.72958 1.000 38.21445 ? 450 HOH B O   1 
HETATM 4745 O O   . HOH E 3 .   ? -2.22566  -2.46661  -1.16087  1.000 27.43516 ? 451 HOH B O   1 
HETATM 4746 O O   . HOH E 3 .   ? 11.83879  5.77174   14.45985  1.000 30.09630 ? 452 HOH B O   1 
HETATM 4747 O O   . HOH E 3 .   ? -5.83836  15.82088  -8.06927  1.000 40.59164 ? 453 HOH B O   1 
HETATM 4748 O O   . HOH E 3 .   ? 8.40339   0.22926   15.92931  1.000 35.27704 ? 454 HOH B O   1 
HETATM 4749 O O   . HOH E 3 .   ? -11.87815 18.16173  12.32891  1.000 46.11902 ? 455 HOH B O   1 
HETATM 4750 O O   . HOH E 3 .   ? 3.77114   -24.05366 -28.92134 1.000 45.37596 ? 456 HOH B O   1 
HETATM 4751 O O   . HOH E 3 .   ? 26.69275  1.97671   2.21649   1.000 46.85678 ? 457 HOH B O   1 
HETATM 4752 O O   . HOH E 3 .   ? 14.51773  20.03404  7.21191   1.000 46.14374 ? 458 HOH B O   1 
HETATM 4753 O O   . HOH E 3 .   ? 7.83460   9.81779   18.41240  1.000 32.95824 ? 459 HOH B O   1 
HETATM 4754 O O   . HOH E 3 .   ? 1.20208   0.04751   5.09802   1.000 29.81117 ? 460 HOH B O   1 
HETATM 4755 O O   . HOH E 3 .   ? -11.41451 6.88785   9.43994   1.000 41.36419 ? 461 HOH B O   1 
HETATM 4756 O O   . HOH E 3 .   ? -4.79322  11.86506  16.24448  1.000 45.28706 ? 462 HOH B O   1 
HETATM 4757 O O   . HOH E 3 .   ? -10.87361 -27.40802 -15.84534 1.000 43.64224 ? 463 HOH B O   1 
HETATM 4758 O O   . HOH E 3 .   ? -1.78416  7.75164   15.43069  1.000 44.50821 ? 464 HOH B O   1 
HETATM 4759 O O   . HOH E 3 .   ? -14.20282 4.94082   1.13422   1.000 35.03210 ? 465 HOH B O   1 
HETATM 4760 O O   . HOH E 3 .   ? 9.84698   17.19238  20.03820  1.000 46.68249 ? 466 HOH B O   1 
HETATM 4761 O O   . HOH E 3 .   ? -5.61012  17.91833  0.08252   1.000 44.51352 ? 467 HOH B O   1 
HETATM 4762 O O   . HOH E 3 .   ? 15.49587  -2.32074  -9.61123  1.000 36.50710 ? 468 HOH B O   1 
HETATM 4763 O O   . HOH E 3 .   ? 16.01700  -10.13766 -7.33638  1.000 44.20417 ? 469 HOH B O   1 
HETATM 4764 O O   . HOH E 3 .   ? 16.25141  3.37783   7.94611   1.000 26.57102 ? 470 HOH B O   1 
HETATM 4765 O O   . HOH E 3 .   ? 2.22012   -10.44400 -15.49230 1.000 28.05699 ? 471 HOH B O   1 
HETATM 4766 O O   . HOH E 3 .   ? 5.62897   9.65091   -12.80860 1.000 53.59362 ? 472 HOH B O   1 
HETATM 4767 O O   . HOH E 3 .   ? 6.97887   -6.72743  -17.23067 1.000 44.45354 ? 473 HOH B O   1 
HETATM 4768 O O   . HOH E 3 .   ? 1.70056   12.60506  16.15648  1.000 37.51954 ? 474 HOH B O   1 
HETATM 4769 O O   . HOH E 3 .   ? 12.64116  8.87283   5.93154   1.000 25.47226 ? 475 HOH B O   1 
HETATM 4770 O O   . HOH E 3 .   ? 22.76753  -7.59504  -6.25667  1.000 43.39000 ? 476 HOH B O   1 
HETATM 4771 O O   . HOH E 3 .   ? 12.08030  -6.06476  2.96165   1.000 28.15012 ? 477 HOH B O   1 
HETATM 4772 O O   . HOH E 3 .   ? -1.30995  -6.90455  -5.13852  1.000 32.40877 ? 478 HOH B O   1 
HETATM 4773 O O   . HOH E 3 .   ? -0.34715  -6.43760  5.98526   1.000 36.11897 ? 479 HOH B O   1 
HETATM 4774 O O   . HOH E 3 .   ? 7.32395   -16.30038 -8.86832  1.000 41.11732 ? 480 HOH B O   1 
HETATM 4775 O O   . HOH E 3 .   ? 10.32322  -11.37144 -22.52022 1.000 46.75581 ? 481 HOH B O   1 
HETATM 4776 O O   . HOH E 3 .   ? -12.52888 4.63352   -6.13778  1.000 39.55376 ? 482 HOH B O   1 
HETATM 4777 O O   . HOH E 3 .   ? -11.77014 -15.20195 -13.99679 1.000 55.68882 ? 483 HOH B O   1 
HETATM 4778 O O   . HOH E 3 .   ? 0.185     -34.483   -23.274   1.000 37.87061 ? 484 HOH B O   1 
HETATM 4779 O O   . HOH E 3 .   ? 11.51656  -12.77983 -20.13109 1.000 45.57394 ? 485 HOH B O   1 
HETATM 4780 O O   . HOH E 3 .   ? -2.73588  -18.04242 -30.67020 1.000 43.98551 ? 486 HOH B O   1 
HETATM 4781 O O   . HOH E 3 .   ? -11.25412 3.21019   7.49401   1.000 34.23465 ? 487 HOH B O   1 
HETATM 4782 O O   . HOH E 3 .   ? 15.60354  -9.10244  -2.49376  1.000 38.27464 ? 488 HOH B O   1 
HETATM 4783 O O   . HOH E 3 .   ? -6.43366  -6.48792  -8.57118  1.000 43.90568 ? 489 HOH B O   1 
HETATM 4784 O O   . HOH E 3 .   ? 8.25757   26.39628  9.92175   1.000 44.23786 ? 490 HOH B O   1 
HETATM 4785 O O   . HOH E 3 .   ? 3.20414   -29.64090 -28.37206 1.000 35.69812 ? 491 HOH B O   1 
HETATM 4786 O O   . HOH E 3 .   ? 8.80914   3.50248   16.13102  1.000 32.84431 ? 492 HOH B O   1 
HETATM 4787 O O   . HOH E 3 .   ? 11.49227  24.21290  10.38617  1.000 42.14335 ? 493 HOH B O   1 
HETATM 4788 O O   . HOH E 3 .   ? -0.57715  -13.97746 -31.43321 1.000 51.30951 ? 494 HOH B O   1 
HETATM 4789 O O   . HOH E 3 .   ? 10.92315  -31.50406 -17.02314 1.000 46.85089 ? 495 HOH B O   1 
HETATM 4790 O O   . HOH E 3 .   ? -9.07442  -22.28788 -21.83425 1.000 52.51577 ? 496 HOH B O   1 
HETATM 4791 O O   . HOH E 3 .   ? -7.61771  23.61946  8.97361   1.000 52.66934 ? 497 HOH B O   1 
HETATM 4792 O O   . HOH E 3 .   ? 10.77291  25.84707  2.56293   1.000 55.64724 ? 498 HOH B O   1 
HETATM 4793 O O   . HOH E 3 .   ? 5.28897   24.84440  18.35394  1.000 49.02967 ? 499 HOH B O   1 
HETATM 4794 O O   . HOH E 3 .   ? -4.55185  29.02275  5.51055   1.000 54.08047 ? 500 HOH B O   1 
HETATM 4795 O O   . HOH E 3 .   ? 3.95557   16.34627  20.10476  1.000 43.69194 ? 501 HOH B O   1 
HETATM 4796 O O   . HOH E 3 .   ? -3.50362  -3.78444  -13.93615 1.000 39.86794 ? 502 HOH B O   1 
HETATM 4797 O O   . HOH E 3 .   ? 18.08440  7.36417   14.57335  1.000 39.91183 ? 503 HOH B O   1 
HETATM 4798 O O   . HOH E 3 .   ? -5.92642  -5.76109  -5.62385  1.000 40.42112 ? 504 HOH B O   1 
HETATM 4799 O O   . HOH E 3 .   ? -13.71057 -11.57563 -14.08982 1.000 54.60331 ? 505 HOH B O   1 
HETATM 4800 O O   . HOH E 3 .   ? -2.35769  19.65961  -1.26340  1.000 42.81081 ? 506 HOH B O   1 
HETATM 4801 O O   . HOH E 3 .   ? 0.11115   4.34819   12.04499  1.000 38.49212 ? 507 HOH B O   1 
HETATM 4802 O O   . HOH E 3 .   ? 5.190     -2.027    12.385    1.000 35.87744 ? 508 HOH B O   1 
HETATM 4803 O O   . HOH E 3 .   ? -10.65337 -8.73847  -16.96023 1.000 51.21331 ? 509 HOH B O   1 
HETATM 4804 O O   . HOH E 3 .   ? 15.27128  21.12660  9.75961   1.000 52.38260 ? 510 HOH B O   1 
HETATM 4805 O O   . HOH E 3 .   ? 8.02539   -25.53371 -3.11725  1.000 51.74544 ? 511 HOH B O   1 
HETATM 4806 O O   . HOH E 3 .   ? 6.06085   -17.74723 -2.35472  1.000 49.65446 ? 512 HOH B O   1 
HETATM 4807 O O   . HOH E 3 .   ? 3.98609   -28.49103 -8.17290  1.000 51.14564 ? 513 HOH B O   1 
HETATM 4808 O O   . HOH E 3 .   ? -1.73414  -10.00310 -5.09566  1.000 46.07234 ? 514 HOH B O   1 
HETATM 4809 O O   . HOH E 3 .   ? -11.76758 -13.15319 -15.73614 1.000 55.49912 ? 515 HOH B O   1 
HETATM 4810 O O   . HOH E 3 .   ? 3.34750   18.82904  20.81694  1.000 47.90553 ? 516 HOH B O   1 
HETATM 4811 O O   . HOH E 3 .   ? 0.48933   12.94640  -16.19815 1.000 41.47232 ? 517 HOH B O   1 
HETATM 4812 O O   . HOH E 3 .   ? 18.767    6.196     11.819    1.000 43.78261 ? 518 HOH B O   1 
HETATM 4813 O O   . HOH E 3 .   ? -11.600   0.065     6.859     1.000 46.10963 ? 519 HOH B O   1 
HETATM 4814 O O   . HOH E 3 .   ? 9.78125   -7.86832  3.47926   1.000 37.35515 ? 520 HOH B O   1 
HETATM 4815 O O   . HOH E 3 .   ? -5.08482  -4.20235  -10.16878 1.000 38.25955 ? 521 HOH B O   1 
HETATM 4816 O O   . HOH E 3 .   ? -8.17821  -11.71623 -17.87862 1.000 42.25897 ? 522 HOH B O   1 
HETATM 4817 O O   . HOH E 3 .   ? -12.15278 12.10304  -2.60070  1.000 45.06271 ? 523 HOH B O   1 
HETATM 4818 O O   . HOH E 3 .   ? -7.88497  17.97618  0.04758   1.000 52.27754 ? 524 HOH B O   1 
HETATM 4819 O O   . HOH E 3 .   ? 11.97656  -6.07574  5.65409   1.000 32.11554 ? 525 HOH B O   1 
HETATM 4820 O O   . HOH E 3 .   ? -2.78016  -6.42612  -2.70624  1.000 48.12087 ? 526 HOH B O   1 
HETATM 4821 O O   . HOH E 3 .   ? -2.61102  16.56185  -13.07169 1.000 47.04356 ? 527 HOH B O   1 
HETATM 4822 O O   . HOH E 3 .   ? 12.73755  -3.73280  7.46113   1.000 37.83844 ? 528 HOH B O   1 
HETATM 4823 O O   . HOH E 3 .   ? -0.93958  2.40457   -15.84424 1.000 43.42296 ? 529 HOH B O   1 
HETATM 4824 O O   . HOH E 3 .   ? -10.54312 -12.14896 -17.24382 1.000 51.68569 ? 530 HOH B O   1 
HETATM 4825 O O   . HOH E 3 .   ? 6.83943   15.68240  21.06865  1.000 45.75791 ? 531 HOH B O   1 
HETATM 4826 O O   . HOH E 3 .   ? -12.96506 10.76543  -5.69076  1.000 41.70711 ? 532 HOH B O   1 
HETATM 4827 O O   . HOH E 3 .   ? 19.134    -5.797    -2.394    1.000 47.15921 ? 533 HOH B O   1 
HETATM 4828 O O   . HOH E 3 .   ? -3.57617  -5.02241  -0.79641  1.000 40.60917 ? 534 HOH B O   1 
HETATM 4829 O O   . HOH E 3 .   ? 23.30079  -4.59336  -3.22862  1.000 45.14485 ? 535 HOH B O   1 
HETATM 4830 O O   . HOH E 3 .   ? 9.661     -8.242    5.721     1.000 40.52306 ? 536 HOH B O   1 
HETATM 4831 O O   . HOH E 3 .   ? -4.74553  17.31260  -11.66111 1.000 49.30696 ? 537 HOH B O   1 
HETATM 4832 O O   . HOH E 3 .   ? -12.78311 -11.09041 -16.37751 1.000 56.57163 ? 538 HOH B O   1 
HETATM 4833 O O   . HOH E 3 .   ? -0.652    -34.052   -34.109   1.000 48.04687 ? 539 HOH B O   1 
HETATM 4834 O O   . HOH E 3 .   ? 25.00302  -2.03198  -0.39414  1.000 52.14118 ? 540 HOH B O   1 
HETATM 4835 O O   . HOH E 3 .   ? 7.90699   10.52720  20.51931  1.000 54.06815 ? 541 HOH B O   1 
HETATM 4836 O O   . HOH E 3 .   ? -2.434    -34.984   -33.257   1.000 52.63132 ? 542 HOH B O   1 
HETATM 4837 O O   . HOH E 3 .   ? -7.74314  -4.48650  -10.65132 1.000 46.15607 ? 543 HOH B O   1 
HETATM 4838 O O   . HOH E 3 .   ? -8.95111  -5.92248  -9.58500  1.000 50.81091 ? 544 HOH B O   1 
HETATM 4839 O O   . HOH E 3 .   ? 14.26054  -35.73224 -10.53884 1.000 58.31339 ? 545 HOH B O   1 
HETATM 4840 O O   . HOH E 3 .   ? 13.90092  -14.60181 -0.12559  1.000 46.42081 ? 546 HOH B O   1 
# 
