data_8YWV
# 
_entry.id   8YWV 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YWV         pdb_00008ywv 10.2210/pdb8ywv/pdb 
WWPDB D_1300046545 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-09 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YWV 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          8YT6 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yo@phs.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Takuya 
_pdbx_contact_author.name_last          Yoshida 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3491-9344 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tachibana, K.' 1  ? 
'Morie, T.'     2  ? 
'Fukuda, S.'    3  ? 
'Yuzuriha, T.'  4  ? 
'Ishimoto, K.'  5  ? 
'Nunomura, K.'  6  ? 
'Lin, B.'       7  ? 
'Miyachi, H.'   8  ? 
'Oki, H.'       9  ? 
'Kawahara, K.'  10 ? 
'Meguro, K.'    11 ? 
'Nakagawa, S.'  12 ? 
'Tsujikawa, K.' 13 ? 
'Akai, S.'      14 ? 
'Doi, T.'       15 ? 
'Yoshida, T.'   16 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural evolution of 1H-pyrazolo[3,4-b]pyridine-derived PPARalpha activators as leads for nonalcoholic steatohepatitis' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tachibana, K.' 1  ? 
primary 'Morie, T.'     2  ? 
primary 'Fukuda, S.'    3  ? 
primary 'Yuzuriha, T.'  4  ? 
primary 'Ishimoto, K.'  5  ? 
primary 'Nunomura, K.'  6  ? 
primary 'Lin, B.'       7  ? 
primary 'Miyachi, H.'   8  ? 
primary 'Oki, H.'       9  ? 
primary 'Kawahara, K.'  10 ? 
primary 'Meguro, K.'    11 ? 
primary 'Nakagawa, S.'  12 ? 
primary 'Tsujikawa, K.' 13 ? 
primary 'Akai, S.'      14 ? 
primary 'Doi, T.'       15 ? 
primary 'Yoshida, T.'   16 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peroxisome proliferator-activated receptor alpha' 30684.814 1  ? ? ? ? 
2 polymer     syn 'Peroxisome proliferator-activated receptor gamma coactivator 1-alpha' 2405.782  1  ? ? ? ? 
3 non-polymer syn 
'1-(4-fluorophenyl)-6-[4-(2-methylpropoxycarbonyl)piperazin-1-yl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 511.588 
1  ? ? ? ? 
4 water       nat water 18.015    89 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'PPAR-alpha,Nuclear receptor subfamily 1 group C member 1'                            
2 'PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
A ? 
2 'polypeptide(L)' no no PQEAEEPSLLKKLLLAPANTQL PQEAEEPSLLKKLLLAPANTQL B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '1-(4-fluorophenyl)-6-[4-(2-methylpropoxycarbonyl)piperazin-1-yl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' A1L0A 
4 water                                                                                                                      HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   GLY n 
1 3   GLN n 
1 4   THR n 
1 5   ALA n 
1 6   ASP n 
1 7   LEU n 
1 8   LYS n 
1 9   SER n 
1 10  LEU n 
1 11  ALA n 
1 12  LYS n 
1 13  ARG n 
1 14  ILE n 
1 15  TYR n 
1 16  GLU n 
1 17  ALA n 
1 18  TYR n 
1 19  LEU n 
1 20  LYS n 
1 21  ASN n 
1 22  PHE n 
1 23  ASN n 
1 24  MET n 
1 25  ASN n 
1 26  LYS n 
1 27  VAL n 
1 28  LYS n 
1 29  ALA n 
1 30  ARG n 
1 31  VAL n 
1 32  ILE n 
1 33  LEU n 
1 34  SER n 
1 35  GLY n 
1 36  LYS n 
1 37  ALA n 
1 38  SER n 
1 39  ASN n 
1 40  ASN n 
1 41  PRO n 
1 42  PRO n 
1 43  PHE n 
1 44  VAL n 
1 45  ILE n 
1 46  HIS n 
1 47  ASP n 
1 48  MET n 
1 49  GLU n 
1 50  THR n 
1 51  LEU n 
1 52  CYS n 
1 53  MET n 
1 54  ALA n 
1 55  GLU n 
1 56  LYS n 
1 57  THR n 
1 58  LEU n 
1 59  VAL n 
1 60  ALA n 
1 61  LYS n 
1 62  LEU n 
1 63  VAL n 
1 64  ALA n 
1 65  ASN n 
1 66  GLY n 
1 67  ILE n 
1 68  GLN n 
1 69  ASN n 
1 70  LYS n 
1 71  GLU n 
1 72  ALA n 
1 73  GLU n 
1 74  VAL n 
1 75  ARG n 
1 76  ILE n 
1 77  PHE n 
1 78  HIS n 
1 79  CYS n 
1 80  CYS n 
1 81  GLN n 
1 82  CYS n 
1 83  THR n 
1 84  SER n 
1 85  VAL n 
1 86  GLU n 
1 87  THR n 
1 88  VAL n 
1 89  THR n 
1 90  GLU n 
1 91  LEU n 
1 92  THR n 
1 93  GLU n 
1 94  PHE n 
1 95  ALA n 
1 96  LYS n 
1 97  ALA n 
1 98  ILE n 
1 99  PRO n 
1 100 GLY n 
1 101 PHE n 
1 102 ALA n 
1 103 ASN n 
1 104 LEU n 
1 105 ASP n 
1 106 LEU n 
1 107 ASN n 
1 108 ASP n 
1 109 GLN n 
1 110 VAL n 
1 111 THR n 
1 112 LEU n 
1 113 LEU n 
1 114 LYS n 
1 115 TYR n 
1 116 GLY n 
1 117 VAL n 
1 118 TYR n 
1 119 GLU n 
1 120 ALA n 
1 121 ILE n 
1 122 PHE n 
1 123 ALA n 
1 124 MET n 
1 125 LEU n 
1 126 SER n 
1 127 SER n 
1 128 VAL n 
1 129 MET n 
1 130 ASN n 
1 131 LYS n 
1 132 ASP n 
1 133 GLY n 
1 134 MET n 
1 135 LEU n 
1 136 VAL n 
1 137 ALA n 
1 138 TYR n 
1 139 GLY n 
1 140 ASN n 
1 141 GLY n 
1 142 PHE n 
1 143 ILE n 
1 144 THR n 
1 145 ARG n 
1 146 GLU n 
1 147 PHE n 
1 148 LEU n 
1 149 LYS n 
1 150 SER n 
1 151 LEU n 
1 152 ARG n 
1 153 LYS n 
1 154 PRO n 
1 155 PHE n 
1 156 CYS n 
1 157 ASP n 
1 158 ILE n 
1 159 MET n 
1 160 GLU n 
1 161 PRO n 
1 162 LYS n 
1 163 PHE n 
1 164 ASP n 
1 165 PHE n 
1 166 ALA n 
1 167 MET n 
1 168 LYS n 
1 169 PHE n 
1 170 ASN n 
1 171 ALA n 
1 172 LEU n 
1 173 GLU n 
1 174 LEU n 
1 175 ASP n 
1 176 ASP n 
1 177 SER n 
1 178 ASP n 
1 179 ILE n 
1 180 SER n 
1 181 LEU n 
1 182 PHE n 
1 183 VAL n 
1 184 ALA n 
1 185 ALA n 
1 186 ILE n 
1 187 ILE n 
1 188 CYS n 
1 189 CYS n 
1 190 GLY n 
1 191 ASP n 
1 192 ARG n 
1 193 PRO n 
1 194 GLY n 
1 195 LEU n 
1 196 LEU n 
1 197 ASN n 
1 198 VAL n 
1 199 GLY n 
1 200 HIS n 
1 201 ILE n 
1 202 GLU n 
1 203 LYS n 
1 204 MET n 
1 205 GLN n 
1 206 GLU n 
1 207 GLY n 
1 208 ILE n 
1 209 VAL n 
1 210 HIS n 
1 211 VAL n 
1 212 LEU n 
1 213 ARG n 
1 214 LEU n 
1 215 HIS n 
1 216 LEU n 
1 217 GLN n 
1 218 SER n 
1 219 ASN n 
1 220 HIS n 
1 221 PRO n 
1 222 ASP n 
1 223 ASP n 
1 224 ILE n 
1 225 PHE n 
1 226 LEU n 
1 227 PHE n 
1 228 PRO n 
1 229 LYS n 
1 230 LEU n 
1 231 LEU n 
1 232 GLN n 
1 233 LYS n 
1 234 MET n 
1 235 ALA n 
1 236 ASP n 
1 237 LEU n 
1 238 ARG n 
1 239 GLN n 
1 240 LEU n 
1 241 VAL n 
1 242 THR n 
1 243 GLU n 
1 244 HIS n 
1 245 ALA n 
1 246 GLN n 
1 247 LEU n 
1 248 VAL n 
1 249 GLN n 
1 250 ILE n 
1 251 ILE n 
1 252 LYS n 
1 253 LYS n 
1 254 THR n 
1 255 GLU n 
1 256 SER n 
1 257 ASP n 
1 258 ALA n 
1 259 ALA n 
1 260 LEU n 
1 261 HIS n 
1 262 PRO n 
1 263 LEU n 
1 264 LEU n 
1 265 GLN n 
1 266 GLU n 
1 267 ILE n 
1 268 TYR n 
1 269 ARG n 
1 270 ASP n 
1 271 MET n 
1 272 TYR n 
2 1   PRO n 
2 2   GLN n 
2 3   GLU n 
2 4   ALA n 
2 5   GLU n 
2 6   GLU n 
2 7   PRO n 
2 8   SER n 
2 9   LEU n 
2 10  LEU n 
2 11  LYS n 
2 12  LYS n 
2 13  LEU n 
2 14  LEU n 
2 15  LEU n 
2 16  ALA n 
2 17  PRO n 
2 18  ALA n 
2 19  ASN n 
2 20  THR n 
2 21  GLN n 
2 22  LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   272 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PPARA, NR1C1, PPAR' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       22 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1L0A non-polymer         . 
'1-(4-fluorophenyl)-6-[4-(2-methylpropoxycarbonyl)piperazin-1-yl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' ? 
'C27 H34 F N5 O4' 511.588 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   197 ?   ?   ?   A . n 
A 1 2   GLY 2   198 ?   ?   ?   A . n 
A 1 3   GLN 3   199 ?   ?   ?   A . n 
A 1 4   THR 4   200 ?   ?   ?   A . n 
A 1 5   ALA 5   201 ?   ?   ?   A . n 
A 1 6   ASP 6   202 ?   ?   ?   A . n 
A 1 7   LEU 7   203 ?   ?   ?   A . n 
A 1 8   LYS 8   204 204 LYS LYS A . n 
A 1 9   SER 9   205 205 SER SER A . n 
A 1 10  LEU 10  206 206 LEU LEU A . n 
A 1 11  ALA 11  207 207 ALA ALA A . n 
A 1 12  LYS 12  208 208 LYS LYS A . n 
A 1 13  ARG 13  209 209 ARG ARG A . n 
A 1 14  ILE 14  210 210 ILE ILE A . n 
A 1 15  TYR 15  211 211 TYR TYR A . n 
A 1 16  GLU 16  212 212 GLU GLU A . n 
A 1 17  ALA 17  213 213 ALA ALA A . n 
A 1 18  TYR 18  214 214 TYR TYR A . n 
A 1 19  LEU 19  215 215 LEU LEU A . n 
A 1 20  LYS 20  216 216 LYS LYS A . n 
A 1 21  ASN 21  217 217 ASN ASN A . n 
A 1 22  PHE 22  218 218 PHE PHE A . n 
A 1 23  ASN 23  219 219 ASN ASN A . n 
A 1 24  MET 24  220 220 MET MET A . n 
A 1 25  ASN 25  221 221 ASN ASN A . n 
A 1 26  LYS 26  222 222 LYS LYS A . n 
A 1 27  VAL 27  223 223 VAL VAL A . n 
A 1 28  LYS 28  224 224 LYS LYS A . n 
A 1 29  ALA 29  225 225 ALA ALA A . n 
A 1 30  ARG 30  226 226 ARG ARG A . n 
A 1 31  VAL 31  227 227 VAL VAL A . n 
A 1 32  ILE 32  228 228 ILE ILE A . n 
A 1 33  LEU 33  229 229 LEU LEU A . n 
A 1 34  SER 34  230 230 SER SER A . n 
A 1 35  GLY 35  231 ?   ?   ?   A . n 
A 1 36  LYS 36  232 ?   ?   ?   A . n 
A 1 37  ALA 37  233 ?   ?   ?   A . n 
A 1 38  SER 38  234 ?   ?   ?   A . n 
A 1 39  ASN 39  235 ?   ?   ?   A . n 
A 1 40  ASN 40  236 ?   ?   ?   A . n 
A 1 41  PRO 41  237 237 PRO PRO A . n 
A 1 42  PRO 42  238 238 PRO PRO A . n 
A 1 43  PHE 43  239 239 PHE PHE A . n 
A 1 44  VAL 44  240 240 VAL VAL A . n 
A 1 45  ILE 45  241 241 ILE ILE A . n 
A 1 46  HIS 46  242 242 HIS HIS A . n 
A 1 47  ASP 47  243 243 ASP ASP A . n 
A 1 48  MET 48  244 244 MET MET A . n 
A 1 49  GLU 49  245 245 GLU GLU A . n 
A 1 50  THR 50  246 246 THR THR A . n 
A 1 51  LEU 51  247 247 LEU LEU A . n 
A 1 52  CYS 52  248 248 CYS CYS A . n 
A 1 53  MET 53  249 249 MET MET A . n 
A 1 54  ALA 54  250 250 ALA ALA A . n 
A 1 55  GLU 55  251 251 GLU GLU A . n 
A 1 56  LYS 56  252 252 LYS LYS A . n 
A 1 57  THR 57  253 253 THR THR A . n 
A 1 58  LEU 58  254 254 LEU LEU A . n 
A 1 59  VAL 59  255 255 VAL VAL A . n 
A 1 60  ALA 60  256 256 ALA ALA A . n 
A 1 61  LYS 61  257 257 LYS LYS A . n 
A 1 62  LEU 62  258 258 LEU LEU A . n 
A 1 63  VAL 63  259 259 VAL VAL A . n 
A 1 64  ALA 64  260 260 ALA ALA A . n 
A 1 65  ASN 65  261 261 ASN ASN A . n 
A 1 66  GLY 66  262 262 GLY GLY A . n 
A 1 67  ILE 67  263 263 ILE ILE A . n 
A 1 68  GLN 68  264 264 GLN GLN A . n 
A 1 69  ASN 69  265 265 ASN ASN A . n 
A 1 70  LYS 70  266 266 LYS LYS A . n 
A 1 71  GLU 71  267 267 GLU GLU A . n 
A 1 72  ALA 72  268 268 ALA ALA A . n 
A 1 73  GLU 73  269 269 GLU GLU A . n 
A 1 74  VAL 74  270 270 VAL VAL A . n 
A 1 75  ARG 75  271 271 ARG ARG A . n 
A 1 76  ILE 76  272 272 ILE ILE A . n 
A 1 77  PHE 77  273 273 PHE PHE A . n 
A 1 78  HIS 78  274 274 HIS HIS A . n 
A 1 79  CYS 79  275 275 CYS CYS A . n 
A 1 80  CYS 80  276 276 CYS CYS A . n 
A 1 81  GLN 81  277 277 GLN GLN A . n 
A 1 82  CYS 82  278 278 CYS CYS A . n 
A 1 83  THR 83  279 279 THR THR A . n 
A 1 84  SER 84  280 280 SER SER A . n 
A 1 85  VAL 85  281 281 VAL VAL A . n 
A 1 86  GLU 86  282 282 GLU GLU A . n 
A 1 87  THR 87  283 283 THR THR A . n 
A 1 88  VAL 88  284 284 VAL VAL A . n 
A 1 89  THR 89  285 285 THR THR A . n 
A 1 90  GLU 90  286 286 GLU GLU A . n 
A 1 91  LEU 91  287 287 LEU LEU A . n 
A 1 92  THR 92  288 288 THR THR A . n 
A 1 93  GLU 93  289 289 GLU GLU A . n 
A 1 94  PHE 94  290 290 PHE PHE A . n 
A 1 95  ALA 95  291 291 ALA ALA A . n 
A 1 96  LYS 96  292 292 LYS LYS A . n 
A 1 97  ALA 97  293 293 ALA ALA A . n 
A 1 98  ILE 98  294 294 ILE ILE A . n 
A 1 99  PRO 99  295 295 PRO PRO A . n 
A 1 100 GLY 100 296 296 GLY GLY A . n 
A 1 101 PHE 101 297 297 PHE PHE A . n 
A 1 102 ALA 102 298 298 ALA ALA A . n 
A 1 103 ASN 103 299 299 ASN ASN A . n 
A 1 104 LEU 104 300 300 LEU LEU A . n 
A 1 105 ASP 105 301 301 ASP ASP A . n 
A 1 106 LEU 106 302 302 LEU LEU A . n 
A 1 107 ASN 107 303 303 ASN ASN A . n 
A 1 108 ASP 108 304 304 ASP ASP A . n 
A 1 109 GLN 109 305 305 GLN GLN A . n 
A 1 110 VAL 110 306 306 VAL VAL A . n 
A 1 111 THR 111 307 307 THR THR A . n 
A 1 112 LEU 112 308 308 LEU LEU A . n 
A 1 113 LEU 113 309 309 LEU LEU A . n 
A 1 114 LYS 114 310 310 LYS LYS A . n 
A 1 115 TYR 115 311 311 TYR TYR A . n 
A 1 116 GLY 116 312 312 GLY GLY A . n 
A 1 117 VAL 117 313 313 VAL VAL A . n 
A 1 118 TYR 118 314 314 TYR TYR A . n 
A 1 119 GLU 119 315 315 GLU GLU A . n 
A 1 120 ALA 120 316 316 ALA ALA A . n 
A 1 121 ILE 121 317 317 ILE ILE A . n 
A 1 122 PHE 122 318 318 PHE PHE A . n 
A 1 123 ALA 123 319 319 ALA ALA A . n 
A 1 124 MET 124 320 320 MET MET A . n 
A 1 125 LEU 125 321 321 LEU LEU A . n 
A 1 126 SER 126 322 322 SER SER A . n 
A 1 127 SER 127 323 323 SER SER A . n 
A 1 128 VAL 128 324 324 VAL VAL A . n 
A 1 129 MET 129 325 325 MET MET A . n 
A 1 130 ASN 130 326 326 ASN ASN A . n 
A 1 131 LYS 131 327 327 LYS LYS A . n 
A 1 132 ASP 132 328 328 ASP ASP A . n 
A 1 133 GLY 133 329 329 GLY GLY A . n 
A 1 134 MET 134 330 330 MET MET A . n 
A 1 135 LEU 135 331 331 LEU LEU A . n 
A 1 136 VAL 136 332 332 VAL VAL A . n 
A 1 137 ALA 137 333 333 ALA ALA A . n 
A 1 138 TYR 138 334 334 TYR TYR A . n 
A 1 139 GLY 139 335 335 GLY GLY A . n 
A 1 140 ASN 140 336 336 ASN ASN A . n 
A 1 141 GLY 141 337 337 GLY GLY A . n 
A 1 142 PHE 142 338 338 PHE PHE A . n 
A 1 143 ILE 143 339 339 ILE ILE A . n 
A 1 144 THR 144 340 340 THR THR A . n 
A 1 145 ARG 145 341 341 ARG ARG A . n 
A 1 146 GLU 146 342 342 GLU GLU A . n 
A 1 147 PHE 147 343 343 PHE PHE A . n 
A 1 148 LEU 148 344 344 LEU LEU A . n 
A 1 149 LYS 149 345 345 LYS LYS A . n 
A 1 150 SER 150 346 346 SER SER A . n 
A 1 151 LEU 151 347 347 LEU LEU A . n 
A 1 152 ARG 152 348 348 ARG ARG A . n 
A 1 153 LYS 153 349 349 LYS LYS A . n 
A 1 154 PRO 154 350 350 PRO PRO A . n 
A 1 155 PHE 155 351 351 PHE PHE A . n 
A 1 156 CYS 156 352 352 CYS CYS A . n 
A 1 157 ASP 157 353 353 ASP ASP A . n 
A 1 158 ILE 158 354 354 ILE ILE A . n 
A 1 159 MET 159 355 355 MET MET A . n 
A 1 160 GLU 160 356 356 GLU GLU A . n 
A 1 161 PRO 161 357 357 PRO PRO A . n 
A 1 162 LYS 162 358 358 LYS LYS A . n 
A 1 163 PHE 163 359 359 PHE PHE A . n 
A 1 164 ASP 164 360 360 ASP ASP A . n 
A 1 165 PHE 165 361 361 PHE PHE A . n 
A 1 166 ALA 166 362 362 ALA ALA A . n 
A 1 167 MET 167 363 363 MET MET A . n 
A 1 168 LYS 168 364 364 LYS LYS A . n 
A 1 169 PHE 169 365 365 PHE PHE A . n 
A 1 170 ASN 170 366 366 ASN ASN A . n 
A 1 171 ALA 171 367 367 ALA ALA A . n 
A 1 172 LEU 172 368 368 LEU LEU A . n 
A 1 173 GLU 173 369 369 GLU GLU A . n 
A 1 174 LEU 174 370 370 LEU LEU A . n 
A 1 175 ASP 175 371 371 ASP ASP A . n 
A 1 176 ASP 176 372 372 ASP ASP A . n 
A 1 177 SER 177 373 373 SER SER A . n 
A 1 178 ASP 178 374 374 ASP ASP A . n 
A 1 179 ILE 179 375 375 ILE ILE A . n 
A 1 180 SER 180 376 376 SER SER A . n 
A 1 181 LEU 181 377 377 LEU LEU A . n 
A 1 182 PHE 182 378 378 PHE PHE A . n 
A 1 183 VAL 183 379 379 VAL VAL A . n 
A 1 184 ALA 184 380 380 ALA ALA A . n 
A 1 185 ALA 185 381 381 ALA ALA A . n 
A 1 186 ILE 186 382 382 ILE ILE A . n 
A 1 187 ILE 187 383 383 ILE ILE A . n 
A 1 188 CYS 188 384 384 CYS CYS A . n 
A 1 189 CYS 189 385 385 CYS CYS A . n 
A 1 190 GLY 190 386 386 GLY GLY A . n 
A 1 191 ASP 191 387 387 ASP ASP A . n 
A 1 192 ARG 192 388 388 ARG ARG A . n 
A 1 193 PRO 193 389 389 PRO PRO A . n 
A 1 194 GLY 194 390 390 GLY GLY A . n 
A 1 195 LEU 195 391 391 LEU LEU A . n 
A 1 196 LEU 196 392 392 LEU LEU A . n 
A 1 197 ASN 197 393 393 ASN ASN A . n 
A 1 198 VAL 198 394 394 VAL VAL A . n 
A 1 199 GLY 199 395 395 GLY GLY A . n 
A 1 200 HIS 200 396 396 HIS HIS A . n 
A 1 201 ILE 201 397 397 ILE ILE A . n 
A 1 202 GLU 202 398 398 GLU GLU A . n 
A 1 203 LYS 203 399 399 LYS LYS A . n 
A 1 204 MET 204 400 400 MET MET A . n 
A 1 205 GLN 205 401 401 GLN GLN A . n 
A 1 206 GLU 206 402 402 GLU GLU A . n 
A 1 207 GLY 207 403 403 GLY GLY A . n 
A 1 208 ILE 208 404 404 ILE ILE A . n 
A 1 209 VAL 209 405 405 VAL VAL A . n 
A 1 210 HIS 210 406 406 HIS HIS A . n 
A 1 211 VAL 211 407 407 VAL VAL A . n 
A 1 212 LEU 212 408 408 LEU LEU A . n 
A 1 213 ARG 213 409 409 ARG ARG A . n 
A 1 214 LEU 214 410 410 LEU LEU A . n 
A 1 215 HIS 215 411 411 HIS HIS A . n 
A 1 216 LEU 216 412 412 LEU LEU A . n 
A 1 217 GLN 217 413 413 GLN GLN A . n 
A 1 218 SER 218 414 414 SER SER A . n 
A 1 219 ASN 219 415 415 ASN ASN A . n 
A 1 220 HIS 220 416 416 HIS HIS A . n 
A 1 221 PRO 221 417 417 PRO PRO A . n 
A 1 222 ASP 222 418 418 ASP ASP A . n 
A 1 223 ASP 223 419 419 ASP ASP A . n 
A 1 224 ILE 224 420 420 ILE ILE A . n 
A 1 225 PHE 225 421 421 PHE PHE A . n 
A 1 226 LEU 226 422 422 LEU LEU A . n 
A 1 227 PHE 227 423 423 PHE PHE A . n 
A 1 228 PRO 228 424 424 PRO PRO A . n 
A 1 229 LYS 229 425 425 LYS LYS A . n 
A 1 230 LEU 230 426 426 LEU LEU A . n 
A 1 231 LEU 231 427 427 LEU LEU A . n 
A 1 232 GLN 232 428 428 GLN GLN A . n 
A 1 233 LYS 233 429 429 LYS LYS A . n 
A 1 234 MET 234 430 430 MET MET A . n 
A 1 235 ALA 235 431 431 ALA ALA A . n 
A 1 236 ASP 236 432 432 ASP ASP A . n 
A 1 237 LEU 237 433 433 LEU LEU A . n 
A 1 238 ARG 238 434 434 ARG ARG A . n 
A 1 239 GLN 239 435 435 GLN GLN A . n 
A 1 240 LEU 240 436 436 LEU LEU A . n 
A 1 241 VAL 241 437 437 VAL VAL A . n 
A 1 242 THR 242 438 438 THR THR A . n 
A 1 243 GLU 243 439 439 GLU GLU A . n 
A 1 244 HIS 244 440 440 HIS HIS A . n 
A 1 245 ALA 245 441 441 ALA ALA A . n 
A 1 246 GLN 246 442 442 GLN GLN A . n 
A 1 247 LEU 247 443 443 LEU LEU A . n 
A 1 248 VAL 248 444 444 VAL VAL A . n 
A 1 249 GLN 249 445 445 GLN GLN A . n 
A 1 250 ILE 250 446 446 ILE ILE A . n 
A 1 251 ILE 251 447 447 ILE ILE A . n 
A 1 252 LYS 252 448 448 LYS LYS A . n 
A 1 253 LYS 253 449 449 LYS LYS A . n 
A 1 254 THR 254 450 450 THR THR A . n 
A 1 255 GLU 255 451 451 GLU GLU A . n 
A 1 256 SER 256 452 452 SER SER A . n 
A 1 257 ASP 257 453 453 ASP ASP A . n 
A 1 258 ALA 258 454 454 ALA ALA A . n 
A 1 259 ALA 259 455 455 ALA ALA A . n 
A 1 260 LEU 260 456 456 LEU LEU A . n 
A 1 261 HIS 261 457 457 HIS HIS A . n 
A 1 262 PRO 262 458 458 PRO PRO A . n 
A 1 263 LEU 263 459 459 LEU LEU A . n 
A 1 264 LEU 264 460 460 LEU LEU A . n 
A 1 265 GLN 265 461 461 GLN GLN A . n 
A 1 266 GLU 266 462 462 GLU GLU A . n 
A 1 267 ILE 267 463 463 ILE ILE A . n 
A 1 268 TYR 268 464 464 TYR TYR A . n 
A 1 269 ARG 269 465 465 ARG ARG A . n 
A 1 270 ASP 270 466 466 ASP ASP A . n 
A 1 271 MET 271 467 467 MET MET A . n 
A 1 272 TYR 272 468 ?   ?   ?   A . n 
B 2 1   PRO 1   135 ?   ?   ?   B . n 
B 2 2   GLN 2   136 ?   ?   ?   B . n 
B 2 3   GLU 3   137 ?   ?   ?   B . n 
B 2 4   ALA 4   138 ?   ?   ?   B . n 
B 2 5   GLU 5   139 ?   ?   ?   B . n 
B 2 6   GLU 6   140 ?   ?   ?   B . n 
B 2 7   PRO 7   141 141 PRO PRO B . n 
B 2 8   SER 8   142 142 SER SER B . n 
B 2 9   LEU 9   143 143 LEU LEU B . n 
B 2 10  LEU 10  144 144 LEU LEU B . n 
B 2 11  LYS 11  145 145 LYS LYS B . n 
B 2 12  LYS 12  146 146 LYS LYS B . n 
B 2 13  LEU 13  147 147 LEU LEU B . n 
B 2 14  LEU 14  148 148 LEU LEU B . n 
B 2 15  LEU 15  149 149 LEU LEU B . n 
B 2 16  ALA 16  150 150 ALA ALA B . n 
B 2 17  PRO 17  151 151 PRO PRO B . n 
B 2 18  ALA 18  152 ?   ?   ?   B . n 
B 2 19  ASN 19  153 ?   ?   ?   B . n 
B 2 20  THR 20  154 ?   ?   ?   B . n 
B 2 21  GLN 21  155 ?   ?   ?   B . n 
B 2 22  LEU 22  156 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1L0A 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1L0A 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1L0A 1  500 500 A1L0A A09 A . 
D 4 HOH   1  601 88  HOH   HOH A . 
D 4 HOH   2  602 77  HOH   HOH A . 
D 4 HOH   3  603 76  HOH   HOH A . 
D 4 HOH   4  604 37  HOH   HOH A . 
D 4 HOH   5  605 72  HOH   HOH A . 
D 4 HOH   6  606 85  HOH   HOH A . 
D 4 HOH   7  607 55  HOH   HOH A . 
D 4 HOH   8  608 84  HOH   HOH A . 
D 4 HOH   9  609 28  HOH   HOH A . 
D 4 HOH   10 610 81  HOH   HOH A . 
D 4 HOH   11 611 60  HOH   HOH A . 
D 4 HOH   12 612 11  HOH   HOH A . 
D 4 HOH   13 613 73  HOH   HOH A . 
D 4 HOH   14 614 19  HOH   HOH A . 
D 4 HOH   15 615 24  HOH   HOH A . 
D 4 HOH   16 616 46  HOH   HOH A . 
D 4 HOH   17 617 34  HOH   HOH A . 
D 4 HOH   18 618 82  HOH   HOH A . 
D 4 HOH   19 619 9   HOH   HOH A . 
D 4 HOH   20 620 32  HOH   HOH A . 
D 4 HOH   21 621 3   HOH   HOH A . 
D 4 HOH   22 622 10  HOH   HOH A . 
D 4 HOH   23 623 33  HOH   HOH A . 
D 4 HOH   24 624 18  HOH   HOH A . 
D 4 HOH   25 625 6   HOH   HOH A . 
D 4 HOH   26 626 1   HOH   HOH A . 
D 4 HOH   27 627 4   HOH   HOH A . 
D 4 HOH   28 628 31  HOH   HOH A . 
D 4 HOH   29 629 35  HOH   HOH A . 
D 4 HOH   30 630 48  HOH   HOH A . 
D 4 HOH   31 631 42  HOH   HOH A . 
D 4 HOH   32 632 17  HOH   HOH A . 
D 4 HOH   33 633 30  HOH   HOH A . 
D 4 HOH   34 634 5   HOH   HOH A . 
D 4 HOH   35 635 21  HOH   HOH A . 
D 4 HOH   36 636 25  HOH   HOH A . 
D 4 HOH   37 637 16  HOH   HOH A . 
D 4 HOH   38 638 41  HOH   HOH A . 
D 4 HOH   39 639 14  HOH   HOH A . 
D 4 HOH   40 640 12  HOH   HOH A . 
D 4 HOH   41 641 13  HOH   HOH A . 
D 4 HOH   42 642 53  HOH   HOH A . 
D 4 HOH   43 643 22  HOH   HOH A . 
D 4 HOH   44 644 70  HOH   HOH A . 
D 4 HOH   45 645 49  HOH   HOH A . 
D 4 HOH   46 646 90  HOH   HOH A . 
D 4 HOH   47 647 47  HOH   HOH A . 
D 4 HOH   48 648 63  HOH   HOH A . 
D 4 HOH   49 649 59  HOH   HOH A . 
D 4 HOH   50 650 2   HOH   HOH A . 
D 4 HOH   51 651 86  HOH   HOH A . 
D 4 HOH   52 652 51  HOH   HOH A . 
D 4 HOH   53 653 15  HOH   HOH A . 
D 4 HOH   54 654 39  HOH   HOH A . 
D 4 HOH   55 655 23  HOH   HOH A . 
D 4 HOH   56 656 71  HOH   HOH A . 
D 4 HOH   57 657 45  HOH   HOH A . 
D 4 HOH   58 658 26  HOH   HOH A . 
D 4 HOH   59 659 43  HOH   HOH A . 
D 4 HOH   60 660 61  HOH   HOH A . 
D 4 HOH   61 661 38  HOH   HOH A . 
D 4 HOH   62 662 20  HOH   HOH A . 
D 4 HOH   63 663 66  HOH   HOH A . 
D 4 HOH   64 664 27  HOH   HOH A . 
D 4 HOH   65 665 7   HOH   HOH A . 
D 4 HOH   66 666 80  HOH   HOH A . 
D 4 HOH   67 667 8   HOH   HOH A . 
D 4 HOH   68 668 40  HOH   HOH A . 
D 4 HOH   69 669 57  HOH   HOH A . 
D 4 HOH   70 670 50  HOH   HOH A . 
D 4 HOH   71 671 64  HOH   HOH A . 
D 4 HOH   72 672 83  HOH   HOH A . 
D 4 HOH   73 673 65  HOH   HOH A . 
D 4 HOH   74 674 69  HOH   HOH A . 
D 4 HOH   75 675 54  HOH   HOH A . 
D 4 HOH   76 676 78  HOH   HOH A . 
D 4 HOH   77 677 58  HOH   HOH A . 
D 4 HOH   78 678 79  HOH   HOH A . 
D 4 HOH   79 679 89  HOH   HOH A . 
D 4 HOH   80 680 52  HOH   HOH A . 
D 4 HOH   81 681 29  HOH   HOH A . 
D 4 HOH   82 682 56  HOH   HOH A . 
D 4 HOH   83 683 36  HOH   HOH A . 
D 4 HOH   84 684 44  HOH   HOH A . 
D 4 HOH   85 685 62  HOH   HOH A . 
D 4 HOH   86 686 75  HOH   HOH A . 
D 4 HOH   87 687 68  HOH   HOH A . 
D 4 HOH   88 688 67  HOH   HOH A . 
E 4 HOH   1  201 87  HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement     ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? phasing        ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .           3 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YWV 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     50.025 
_cell.length_a_esd                 ? 
_cell.length_b                     61.493 
_cell.length_b_esd                 ? 
_cell.length_c                     97.540 
_cell.length_c_esd                 ? 
_cell.volume                       300051.312 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YWV 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YWV 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.27 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.74 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES-NaOH, 19-23% PEG 4000, 19-23% 1,2-propanediol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-02-03 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL45XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL45XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          44.37 
_reflns.entry_id                                       8YWV 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.01 
_reflns.d_resolution_low                               44.51 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38554 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.85 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.092 
_reflns.pdbx_Rpim_I_all                                0.035 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.085 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.01 
_reflns_shell.d_res_low                                     2.08 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3873 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.521 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               48.84 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YWV 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.01 
_refine.ls_d_res_low                             44.51 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20668 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  18668 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.69 
_refine.ls_percent_reflns_R_free                 9.68 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2068 
_refine.ls_R_factor_R_free                       0.2511 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2021 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.3732 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2904 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.01 
_refine_hist.d_res_low                        44.51 
_refine_hist.number_atoms_solvent             89 
_refine_hist.number_atoms_total               2258 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2132 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         37 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0082  ? 2209 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9610  ? 2978 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0568  ? 342  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0058  ? 371  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 24.5780 ? 859  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.01 2.06  . . 136 1270 97.23  . . . . 0.3497 . . . . . . . . . . . 0.4153 
'X-RAY DIFFRACTION' 2.06 2.11  . . 140 1305 99.93  . . . . 0.2854 . . . . . . . . . . . 0.3181 
'X-RAY DIFFRACTION' 2.11 2.18  . . 141 1320 99.66  . . . . 0.2564 . . . . . . . . . . . 0.3310 
'X-RAY DIFFRACTION' 2.18 2.25  . . 139 1301 99.72  . . . . 0.2325 . . . . . . . . . . . 0.3444 
'X-RAY DIFFRACTION' 2.25 2.33  . . 142 1318 99.86  . . . . 0.2371 . . . . . . . . . . . 0.2938 
'X-RAY DIFFRACTION' 2.33 2.42  . . 141 1315 99.86  . . . . 0.2396 . . . . . . . . . . . 0.2722 
'X-RAY DIFFRACTION' 2.42 2.53  . . 140 1312 99.93  . . . . 0.2222 . . . . . . . . . . . 0.3545 
'X-RAY DIFFRACTION' 2.53 2.66  . . 144 1335 100.00 . . . . 0.2259 . . . . . . . . . . . 0.2540 
'X-RAY DIFFRACTION' 2.66 2.83  . . 142 1332 99.86  . . . . 0.2231 . . . . . . . . . . . 0.3041 
'X-RAY DIFFRACTION' 2.83 3.05  . . 144 1346 100.00 . . . . 0.2329 . . . . . . . . . . . 0.2767 
'X-RAY DIFFRACTION' 3.05 3.35  . . 144 1334 99.93  . . . . 0.2240 . . . . . . . . . . . 0.2693 
'X-RAY DIFFRACTION' 3.36 3.84  . . 145 1358 99.93  . . . . 0.1865 . . . . . . . . . . . 0.2064 
'X-RAY DIFFRACTION' 3.84 4.84  . . 146 1365 100.00 . . . . 0.1690 . . . . . . . . . . . 0.1845 
'X-RAY DIFFRACTION' 4.84 44.51 . . 156 1457 100.00 . . . . 0.1759 . . . . . . . . . . . 0.2527 
# 
_struct.entry_id                     8YWV 
_struct.title                        
'Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YWV 
_struct_keywords.text            'Agonist, Complex, Nuclear receptor, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PPARA_HUMAN Q07869 ? 1 
;TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT
SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE
HAQLVQIIKKTESDAALHPLLQEIYRDMY
;
200 
2 UNP PRGC1_HUMAN Q9UBK2 ? 2 PQEAEEPSLLKKLLLAPANTQL 135 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YWV A 4 ? 272 ? Q07869 200 ? 468 ? 200 468 
2 2 8YWV B 1 ? 22  ? Q9UBK2 135 ? 156 ? 135 156 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YWV GLY A 1 ? UNP Q07869 ? ? 'expression tag' 197 1 
1 8YWV GLY A 2 ? UNP Q07869 ? ? 'expression tag' 198 2 
1 8YWV GLN A 3 ? UNP Q07869 ? ? 'expression tag' 199 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1080  ? 
1 MORE         -10   ? 
1 'SSA (A^2)'  12860 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? PHE A 22  ? SER A 205 PHE A 218 1 ? 14 
HELX_P HELX_P2  AA2 ASN A 25  ? SER A 34  ? ASN A 221 SER A 230 1 ? 10 
HELX_P HELX_P3  AA3 ASP A 47  ? VAL A 59  ? ASP A 243 VAL A 255 1 ? 13 
HELX_P HELX_P4  AA4 VAL A 59  ? ALA A 64  ? VAL A 255 ALA A 260 1 ? 6  
HELX_P HELX_P5  AA5 GLU A 71  ? ALA A 97  ? GLU A 267 ALA A 293 1 ? 27 
HELX_P HELX_P6  AA6 GLY A 100 ? LEU A 104 ? GLY A 296 LEU A 300 5 ? 5  
HELX_P HELX_P7  AA7 ASP A 105 ? SER A 126 ? ASP A 301 SER A 322 1 ? 22 
HELX_P HELX_P8  AA8 ARG A 145 ? SER A 150 ? ARG A 341 SER A 346 1 ? 6  
HELX_P HELX_P9  AA9 PRO A 154 ? ILE A 158 ? PRO A 350 ILE A 354 5 ? 5  
HELX_P HELX_P10 AB1 MET A 159 ? LEU A 172 ? MET A 355 LEU A 368 1 ? 14 
HELX_P HELX_P11 AB2 ASP A 175 ? CYS A 188 ? ASP A 371 CYS A 384 1 ? 14 
HELX_P HELX_P12 AB3 ASN A 197 ? HIS A 220 ? ASN A 393 HIS A 416 1 ? 24 
HELX_P HELX_P13 AB4 PHE A 225 ? GLU A 255 ? PHE A 421 GLU A 451 1 ? 31 
HELX_P HELX_P14 AB5 HIS A 261 ? ARG A 269 ? HIS A 457 ARG A 465 1 ? 9  
HELX_P HELX_P15 AB6 SER B 8   ? ALA B 16  ? SER B 142 ALA B 150 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LYS 
_struct_mon_prot_cis.label_seq_id           153 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LYS 
_struct_mon_prot_cis.auth_seq_id            349 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    154 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     350 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -3.00 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   4 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 43  ? ILE A 45  ? PHE A 239 ILE A 241 
AA1 2 GLY A 141 ? THR A 144 ? GLY A 337 THR A 340 
AA1 3 GLY A 133 ? VAL A 136 ? GLY A 329 VAL A 332 
AA1 4 MET A 129 ? ASN A 130 ? MET A 325 ASN A 326 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 45  ? N ILE A 241 O PHE A 142 ? O PHE A 338 
AA1 2 3 O GLY A 141 ? O GLY A 337 N VAL A 136 ? N VAL A 332 
AA1 3 4 O GLY A 133 ? O GLY A 329 N ASN A 130 ? N ASN A 326 
# 
_pdbx_entry_details.entry_id                   8YWV 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU A 392 ? ? -95.57  -60.59 
2 1 ALA A 454 ? ? -114.68 72.11  
3 1 ASP A 466 ? ? 32.96   67.18  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 197 ? A GLY 1   
2  1 Y 1 A GLY 198 ? A GLY 2   
3  1 Y 1 A GLN 199 ? A GLN 3   
4  1 Y 1 A THR 200 ? A THR 4   
5  1 Y 1 A ALA 201 ? A ALA 5   
6  1 Y 1 A ASP 202 ? A ASP 6   
7  1 Y 1 A LEU 203 ? A LEU 7   
8  1 Y 1 A GLY 231 ? A GLY 35  
9  1 Y 1 A LYS 232 ? A LYS 36  
10 1 Y 1 A ALA 233 ? A ALA 37  
11 1 Y 1 A SER 234 ? A SER 38  
12 1 Y 1 A ASN 235 ? A ASN 39  
13 1 Y 1 A ASN 236 ? A ASN 40  
14 1 Y 1 A TYR 468 ? A TYR 272 
15 1 Y 1 B PRO 135 ? B PRO 1   
16 1 Y 1 B GLN 136 ? B GLN 2   
17 1 Y 1 B GLU 137 ? B GLU 3   
18 1 Y 1 B ALA 138 ? B ALA 4   
19 1 Y 1 B GLU 139 ? B GLU 5   
20 1 Y 1 B GLU 140 ? B GLU 6   
21 1 Y 1 B ALA 152 ? B ALA 18  
22 1 Y 1 B ASN 153 ? B ASN 19  
23 1 Y 1 B THR 154 ? B THR 20  
24 1 Y 1 B GLN 155 ? B GLN 21  
25 1 Y 1 B LEU 156 ? B LEU 22  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1L0A C01  C Y N 1   
A1L0A C02  C Y N 2   
A1L0A C03  C Y N 3   
A1L0A C04  C Y N 4   
A1L0A C05  C Y N 5   
A1L0A C06  C Y N 6   
A1L0A C08  C N N 7   
A1L0A C09  C N N 8   
A1L0A C10  C N N 9   
A1L0A C11  C N N 10  
A1L0A C12  C N N 11  
A1L0A C13  C N N 12  
A1L0A C14  C Y N 13  
A1L0A C15  C Y N 14  
A1L0A C16  C Y N 15  
A1L0A C17  C Y N 16  
A1L0A C18  C Y N 17  
A1L0A C19  C Y N 18  
A1L0A C26  C N N 19  
A1L0A C27  C N N 20  
A1L0A C28  C N N 21  
A1L0A C29  C N N 22  
A1L0A C31  C N N 23  
A1L0A C32  C N N 24  
A1L0A C35  C N N 25  
A1L0A C36  C N N 26  
A1L0A C37  C N N 27  
A1L0A F20  F N N 28  
A1L0A N07  N N N 29  
A1L0A N21  N Y N 30  
A1L0A N22  N Y N 31  
A1L0A N23  N Y N 32  
A1L0A N30  N N N 33  
A1L0A O24  O N N 34  
A1L0A O25  O N N 35  
A1L0A O33  O N N 36  
A1L0A O34  O N N 37  
A1L0A H1   H N N 38  
A1L0A H2   H N N 39  
A1L0A H3   H N N 40  
A1L0A H4   H N N 41  
A1L0A H5   H N N 42  
A1L0A H6   H N N 43  
A1L0A H7   H N N 44  
A1L0A H8   H N N 45  
A1L0A H9   H N N 46  
A1L0A H10  H N N 47  
A1L0A H11  H N N 48  
A1L0A H12  H N N 49  
A1L0A H13  H N N 50  
A1L0A H14  H N N 51  
A1L0A H15  H N N 52  
A1L0A H16  H N N 53  
A1L0A H17  H N N 54  
A1L0A H18  H N N 55  
A1L0A H19  H N N 56  
A1L0A H20  H N N 57  
A1L0A H21  H N N 58  
A1L0A H22  H N N 59  
A1L0A H23  H N N 60  
A1L0A H24  H N N 61  
A1L0A H25  H N N 62  
A1L0A H26  H N N 63  
A1L0A H27  H N N 64  
A1L0A H28  H N N 65  
A1L0A H29  H N N 66  
A1L0A H30  H N N 67  
A1L0A H31  H N N 68  
A1L0A H32  H N N 69  
A1L0A H33  H N N 70  
A1L0A H34  H N N 71  
ALA   N    N N N 72  
ALA   CA   C N S 73  
ALA   C    C N N 74  
ALA   O    O N N 75  
ALA   CB   C N N 76  
ALA   OXT  O N N 77  
ALA   H    H N N 78  
ALA   H2   H N N 79  
ALA   HA   H N N 80  
ALA   HB1  H N N 81  
ALA   HB2  H N N 82  
ALA   HB3  H N N 83  
ALA   HXT  H N N 84  
ARG   N    N N N 85  
ARG   CA   C N S 86  
ARG   C    C N N 87  
ARG   O    O N N 88  
ARG   CB   C N N 89  
ARG   CG   C N N 90  
ARG   CD   C N N 91  
ARG   NE   N N N 92  
ARG   CZ   C N N 93  
ARG   NH1  N N N 94  
ARG   NH2  N N N 95  
ARG   OXT  O N N 96  
ARG   H    H N N 97  
ARG   H2   H N N 98  
ARG   HA   H N N 99  
ARG   HB2  H N N 100 
ARG   HB3  H N N 101 
ARG   HG2  H N N 102 
ARG   HG3  H N N 103 
ARG   HD2  H N N 104 
ARG   HD3  H N N 105 
ARG   HE   H N N 106 
ARG   HH11 H N N 107 
ARG   HH12 H N N 108 
ARG   HH21 H N N 109 
ARG   HH22 H N N 110 
ARG   HXT  H N N 111 
ASN   N    N N N 112 
ASN   CA   C N S 113 
ASN   C    C N N 114 
ASN   O    O N N 115 
ASN   CB   C N N 116 
ASN   CG   C N N 117 
ASN   OD1  O N N 118 
ASN   ND2  N N N 119 
ASN   OXT  O N N 120 
ASN   H    H N N 121 
ASN   H2   H N N 122 
ASN   HA   H N N 123 
ASN   HB2  H N N 124 
ASN   HB3  H N N 125 
ASN   HD21 H N N 126 
ASN   HD22 H N N 127 
ASN   HXT  H N N 128 
ASP   N    N N N 129 
ASP   CA   C N S 130 
ASP   C    C N N 131 
ASP   O    O N N 132 
ASP   CB   C N N 133 
ASP   CG   C N N 134 
ASP   OD1  O N N 135 
ASP   OD2  O N N 136 
ASP   OXT  O N N 137 
ASP   H    H N N 138 
ASP   H2   H N N 139 
ASP   HA   H N N 140 
ASP   HB2  H N N 141 
ASP   HB3  H N N 142 
ASP   HD2  H N N 143 
ASP   HXT  H N N 144 
CYS   N    N N N 145 
CYS   CA   C N R 146 
CYS   C    C N N 147 
CYS   O    O N N 148 
CYS   CB   C N N 149 
CYS   SG   S N N 150 
CYS   OXT  O N N 151 
CYS   H    H N N 152 
CYS   H2   H N N 153 
CYS   HA   H N N 154 
CYS   HB2  H N N 155 
CYS   HB3  H N N 156 
CYS   HG   H N N 157 
CYS   HXT  H N N 158 
GLN   N    N N N 159 
GLN   CA   C N S 160 
GLN   C    C N N 161 
GLN   O    O N N 162 
GLN   CB   C N N 163 
GLN   CG   C N N 164 
GLN   CD   C N N 165 
GLN   OE1  O N N 166 
GLN   NE2  N N N 167 
GLN   OXT  O N N 168 
GLN   H    H N N 169 
GLN   H2   H N N 170 
GLN   HA   H N N 171 
GLN   HB2  H N N 172 
GLN   HB3  H N N 173 
GLN   HG2  H N N 174 
GLN   HG3  H N N 175 
GLN   HE21 H N N 176 
GLN   HE22 H N N 177 
GLN   HXT  H N N 178 
GLU   N    N N N 179 
GLU   CA   C N S 180 
GLU   C    C N N 181 
GLU   O    O N N 182 
GLU   CB   C N N 183 
GLU   CG   C N N 184 
GLU   CD   C N N 185 
GLU   OE1  O N N 186 
GLU   OE2  O N N 187 
GLU   OXT  O N N 188 
GLU   H    H N N 189 
GLU   H2   H N N 190 
GLU   HA   H N N 191 
GLU   HB2  H N N 192 
GLU   HB3  H N N 193 
GLU   HG2  H N N 194 
GLU   HG3  H N N 195 
GLU   HE2  H N N 196 
GLU   HXT  H N N 197 
GLY   N    N N N 198 
GLY   CA   C N N 199 
GLY   C    C N N 200 
GLY   O    O N N 201 
GLY   OXT  O N N 202 
GLY   H    H N N 203 
GLY   H2   H N N 204 
GLY   HA2  H N N 205 
GLY   HA3  H N N 206 
GLY   HXT  H N N 207 
HIS   N    N N N 208 
HIS   CA   C N S 209 
HIS   C    C N N 210 
HIS   O    O N N 211 
HIS   CB   C N N 212 
HIS   CG   C Y N 213 
HIS   ND1  N Y N 214 
HIS   CD2  C Y N 215 
HIS   CE1  C Y N 216 
HIS   NE2  N Y N 217 
HIS   OXT  O N N 218 
HIS   H    H N N 219 
HIS   H2   H N N 220 
HIS   HA   H N N 221 
HIS   HB2  H N N 222 
HIS   HB3  H N N 223 
HIS   HD1  H N N 224 
HIS   HD2  H N N 225 
HIS   HE1  H N N 226 
HIS   HE2  H N N 227 
HIS   HXT  H N N 228 
HOH   O    O N N 229 
HOH   H1   H N N 230 
HOH   H2   H N N 231 
ILE   N    N N N 232 
ILE   CA   C N S 233 
ILE   C    C N N 234 
ILE   O    O N N 235 
ILE   CB   C N S 236 
ILE   CG1  C N N 237 
ILE   CG2  C N N 238 
ILE   CD1  C N N 239 
ILE   OXT  O N N 240 
ILE   H    H N N 241 
ILE   H2   H N N 242 
ILE   HA   H N N 243 
ILE   HB   H N N 244 
ILE   HG12 H N N 245 
ILE   HG13 H N N 246 
ILE   HG21 H N N 247 
ILE   HG22 H N N 248 
ILE   HG23 H N N 249 
ILE   HD11 H N N 250 
ILE   HD12 H N N 251 
ILE   HD13 H N N 252 
ILE   HXT  H N N 253 
LEU   N    N N N 254 
LEU   CA   C N S 255 
LEU   C    C N N 256 
LEU   O    O N N 257 
LEU   CB   C N N 258 
LEU   CG   C N N 259 
LEU   CD1  C N N 260 
LEU   CD2  C N N 261 
LEU   OXT  O N N 262 
LEU   H    H N N 263 
LEU   H2   H N N 264 
LEU   HA   H N N 265 
LEU   HB2  H N N 266 
LEU   HB3  H N N 267 
LEU   HG   H N N 268 
LEU   HD11 H N N 269 
LEU   HD12 H N N 270 
LEU   HD13 H N N 271 
LEU   HD21 H N N 272 
LEU   HD22 H N N 273 
LEU   HD23 H N N 274 
LEU   HXT  H N N 275 
LYS   N    N N N 276 
LYS   CA   C N S 277 
LYS   C    C N N 278 
LYS   O    O N N 279 
LYS   CB   C N N 280 
LYS   CG   C N N 281 
LYS   CD   C N N 282 
LYS   CE   C N N 283 
LYS   NZ   N N N 284 
LYS   OXT  O N N 285 
LYS   H    H N N 286 
LYS   H2   H N N 287 
LYS   HA   H N N 288 
LYS   HB2  H N N 289 
LYS   HB3  H N N 290 
LYS   HG2  H N N 291 
LYS   HG3  H N N 292 
LYS   HD2  H N N 293 
LYS   HD3  H N N 294 
LYS   HE2  H N N 295 
LYS   HE3  H N N 296 
LYS   HZ1  H N N 297 
LYS   HZ2  H N N 298 
LYS   HZ3  H N N 299 
LYS   HXT  H N N 300 
MET   N    N N N 301 
MET   CA   C N S 302 
MET   C    C N N 303 
MET   O    O N N 304 
MET   CB   C N N 305 
MET   CG   C N N 306 
MET   SD   S N N 307 
MET   CE   C N N 308 
MET   OXT  O N N 309 
MET   H    H N N 310 
MET   H2   H N N 311 
MET   HA   H N N 312 
MET   HB2  H N N 313 
MET   HB3  H N N 314 
MET   HG2  H N N 315 
MET   HG3  H N N 316 
MET   HE1  H N N 317 
MET   HE2  H N N 318 
MET   HE3  H N N 319 
MET   HXT  H N N 320 
PHE   N    N N N 321 
PHE   CA   C N S 322 
PHE   C    C N N 323 
PHE   O    O N N 324 
PHE   CB   C N N 325 
PHE   CG   C Y N 326 
PHE   CD1  C Y N 327 
PHE   CD2  C Y N 328 
PHE   CE1  C Y N 329 
PHE   CE2  C Y N 330 
PHE   CZ   C Y N 331 
PHE   OXT  O N N 332 
PHE   H    H N N 333 
PHE   H2   H N N 334 
PHE   HA   H N N 335 
PHE   HB2  H N N 336 
PHE   HB3  H N N 337 
PHE   HD1  H N N 338 
PHE   HD2  H N N 339 
PHE   HE1  H N N 340 
PHE   HE2  H N N 341 
PHE   HZ   H N N 342 
PHE   HXT  H N N 343 
PRO   N    N N N 344 
PRO   CA   C N S 345 
PRO   C    C N N 346 
PRO   O    O N N 347 
PRO   CB   C N N 348 
PRO   CG   C N N 349 
PRO   CD   C N N 350 
PRO   OXT  O N N 351 
PRO   H    H N N 352 
PRO   HA   H N N 353 
PRO   HB2  H N N 354 
PRO   HB3  H N N 355 
PRO   HG2  H N N 356 
PRO   HG3  H N N 357 
PRO   HD2  H N N 358 
PRO   HD3  H N N 359 
PRO   HXT  H N N 360 
SER   N    N N N 361 
SER   CA   C N S 362 
SER   C    C N N 363 
SER   O    O N N 364 
SER   CB   C N N 365 
SER   OG   O N N 366 
SER   OXT  O N N 367 
SER   H    H N N 368 
SER   H2   H N N 369 
SER   HA   H N N 370 
SER   HB2  H N N 371 
SER   HB3  H N N 372 
SER   HG   H N N 373 
SER   HXT  H N N 374 
THR   N    N N N 375 
THR   CA   C N S 376 
THR   C    C N N 377 
THR   O    O N N 378 
THR   CB   C N R 379 
THR   OG1  O N N 380 
THR   CG2  C N N 381 
THR   OXT  O N N 382 
THR   H    H N N 383 
THR   H2   H N N 384 
THR   HA   H N N 385 
THR   HB   H N N 386 
THR   HG1  H N N 387 
THR   HG21 H N N 388 
THR   HG22 H N N 389 
THR   HG23 H N N 390 
THR   HXT  H N N 391 
TYR   N    N N N 392 
TYR   CA   C N S 393 
TYR   C    C N N 394 
TYR   O    O N N 395 
TYR   CB   C N N 396 
TYR   CG   C Y N 397 
TYR   CD1  C Y N 398 
TYR   CD2  C Y N 399 
TYR   CE1  C Y N 400 
TYR   CE2  C Y N 401 
TYR   CZ   C Y N 402 
TYR   OH   O N N 403 
TYR   OXT  O N N 404 
TYR   H    H N N 405 
TYR   H2   H N N 406 
TYR   HA   H N N 407 
TYR   HB2  H N N 408 
TYR   HB3  H N N 409 
TYR   HD1  H N N 410 
TYR   HD2  H N N 411 
TYR   HE1  H N N 412 
TYR   HE2  H N N 413 
TYR   HH   H N N 414 
TYR   HXT  H N N 415 
VAL   N    N N N 416 
VAL   CA   C N S 417 
VAL   C    C N N 418 
VAL   O    O N N 419 
VAL   CB   C N N 420 
VAL   CG1  C N N 421 
VAL   CG2  C N N 422 
VAL   OXT  O N N 423 
VAL   H    H N N 424 
VAL   H2   H N N 425 
VAL   HA   H N N 426 
VAL   HB   H N N 427 
VAL   HG11 H N N 428 
VAL   HG12 H N N 429 
VAL   HG13 H N N 430 
VAL   HG21 H N N 431 
VAL   HG22 H N N 432 
VAL   HG23 H N N 433 
VAL   HXT  H N N 434 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1L0A C01 C02  doub Y N 1   
A1L0A C01 N07  sing N N 2   
A1L0A C01 N21  sing Y N 3   
A1L0A C02 C03  sing Y N 4   
A1L0A C03 C04  doub Y N 5   
A1L0A C03 C08  sing N N 6   
A1L0A C04 C05  sing Y N 7   
A1L0A C04 C06  sing Y N 8   
A1L0A C05 N21  doub Y N 9   
A1L0A C05 N23  sing Y N 10  
A1L0A C06 C09  sing N N 11  
A1L0A C06 N22  doub Y N 12  
A1L0A C08 O24  doub N N 13  
A1L0A C08 O25  sing N N 14  
A1L0A C09 C10  sing N N 15  
A1L0A C09 C11  sing N N 16  
A1L0A C10 C12  sing N N 17  
A1L0A C11 C13  sing N N 18  
A1L0A C14 C15  doub Y N 19  
A1L0A C14 C19  sing Y N 20  
A1L0A C15 C16  sing Y N 21  
A1L0A C16 C17  doub Y N 22  
A1L0A C16 F20  sing N N 23  
A1L0A C17 C18  sing Y N 24  
A1L0A C18 C19  doub Y N 25  
A1L0A C19 N23  sing N N 26  
A1L0A N22 N23  sing Y N 27  
A1L0A C28 C29  sing N N 28  
A1L0A C29 N30  sing N N 29  
A1L0A N30 C31  sing N N 30  
A1L0A C31 C32  sing N N 31  
A1L0A N07 C28  sing N N 32  
A1L0A N07 C32  sing N N 33  
A1L0A N30 C26  sing N N 34  
A1L0A C26 O33  doub N N 35  
A1L0A C26 O34  sing N N 36  
A1L0A O34 C27  sing N N 37  
A1L0A C27 C35  sing N N 38  
A1L0A C35 C36  sing N N 39  
A1L0A C35 C37  sing N N 40  
A1L0A C02 H1   sing N N 41  
A1L0A C09 H2   sing N N 42  
A1L0A C10 H3   sing N N 43  
A1L0A C10 H4   sing N N 44  
A1L0A C11 H5   sing N N 45  
A1L0A C11 H6   sing N N 46  
A1L0A C12 H7   sing N N 47  
A1L0A C12 H8   sing N N 48  
A1L0A C12 H9   sing N N 49  
A1L0A C13 H10  sing N N 50  
A1L0A C13 H11  sing N N 51  
A1L0A C13 H12  sing N N 52  
A1L0A C14 H13  sing N N 53  
A1L0A C15 H14  sing N N 54  
A1L0A C17 H15  sing N N 55  
A1L0A C18 H16  sing N N 56  
A1L0A C27 H17  sing N N 57  
A1L0A C27 H18  sing N N 58  
A1L0A C28 H19  sing N N 59  
A1L0A C28 H20  sing N N 60  
A1L0A C29 H21  sing N N 61  
A1L0A C29 H22  sing N N 62  
A1L0A C31 H23  sing N N 63  
A1L0A C31 H24  sing N N 64  
A1L0A C32 H25  sing N N 65  
A1L0A C32 H26  sing N N 66  
A1L0A C35 H27  sing N N 67  
A1L0A C36 H28  sing N N 68  
A1L0A C36 H29  sing N N 69  
A1L0A C36 H30  sing N N 70  
A1L0A C37 H31  sing N N 71  
A1L0A C37 H32  sing N N 72  
A1L0A C37 H33  sing N N 73  
A1L0A O25 H34  sing N N 74  
ALA   N   CA   sing N N 75  
ALA   N   H    sing N N 76  
ALA   N   H2   sing N N 77  
ALA   CA  C    sing N N 78  
ALA   CA  CB   sing N N 79  
ALA   CA  HA   sing N N 80  
ALA   C   O    doub N N 81  
ALA   C   OXT  sing N N 82  
ALA   CB  HB1  sing N N 83  
ALA   CB  HB2  sing N N 84  
ALA   CB  HB3  sing N N 85  
ALA   OXT HXT  sing N N 86  
ARG   N   CA   sing N N 87  
ARG   N   H    sing N N 88  
ARG   N   H2   sing N N 89  
ARG   CA  C    sing N N 90  
ARG   CA  CB   sing N N 91  
ARG   CA  HA   sing N N 92  
ARG   C   O    doub N N 93  
ARG   C   OXT  sing N N 94  
ARG   CB  CG   sing N N 95  
ARG   CB  HB2  sing N N 96  
ARG   CB  HB3  sing N N 97  
ARG   CG  CD   sing N N 98  
ARG   CG  HG2  sing N N 99  
ARG   CG  HG3  sing N N 100 
ARG   CD  NE   sing N N 101 
ARG   CD  HD2  sing N N 102 
ARG   CD  HD3  sing N N 103 
ARG   NE  CZ   sing N N 104 
ARG   NE  HE   sing N N 105 
ARG   CZ  NH1  sing N N 106 
ARG   CZ  NH2  doub N N 107 
ARG   NH1 HH11 sing N N 108 
ARG   NH1 HH12 sing N N 109 
ARG   NH2 HH21 sing N N 110 
ARG   NH2 HH22 sing N N 111 
ARG   OXT HXT  sing N N 112 
ASN   N   CA   sing N N 113 
ASN   N   H    sing N N 114 
ASN   N   H2   sing N N 115 
ASN   CA  C    sing N N 116 
ASN   CA  CB   sing N N 117 
ASN   CA  HA   sing N N 118 
ASN   C   O    doub N N 119 
ASN   C   OXT  sing N N 120 
ASN   CB  CG   sing N N 121 
ASN   CB  HB2  sing N N 122 
ASN   CB  HB3  sing N N 123 
ASN   CG  OD1  doub N N 124 
ASN   CG  ND2  sing N N 125 
ASN   ND2 HD21 sing N N 126 
ASN   ND2 HD22 sing N N 127 
ASN   OXT HXT  sing N N 128 
ASP   N   CA   sing N N 129 
ASP   N   H    sing N N 130 
ASP   N   H2   sing N N 131 
ASP   CA  C    sing N N 132 
ASP   CA  CB   sing N N 133 
ASP   CA  HA   sing N N 134 
ASP   C   O    doub N N 135 
ASP   C   OXT  sing N N 136 
ASP   CB  CG   sing N N 137 
ASP   CB  HB2  sing N N 138 
ASP   CB  HB3  sing N N 139 
ASP   CG  OD1  doub N N 140 
ASP   CG  OD2  sing N N 141 
ASP   OD2 HD2  sing N N 142 
ASP   OXT HXT  sing N N 143 
CYS   N   CA   sing N N 144 
CYS   N   H    sing N N 145 
CYS   N   H2   sing N N 146 
CYS   CA  C    sing N N 147 
CYS   CA  CB   sing N N 148 
CYS   CA  HA   sing N N 149 
CYS   C   O    doub N N 150 
CYS   C   OXT  sing N N 151 
CYS   CB  SG   sing N N 152 
CYS   CB  HB2  sing N N 153 
CYS   CB  HB3  sing N N 154 
CYS   SG  HG   sing N N 155 
CYS   OXT HXT  sing N N 156 
GLN   N   CA   sing N N 157 
GLN   N   H    sing N N 158 
GLN   N   H2   sing N N 159 
GLN   CA  C    sing N N 160 
GLN   CA  CB   sing N N 161 
GLN   CA  HA   sing N N 162 
GLN   C   O    doub N N 163 
GLN   C   OXT  sing N N 164 
GLN   CB  CG   sing N N 165 
GLN   CB  HB2  sing N N 166 
GLN   CB  HB3  sing N N 167 
GLN   CG  CD   sing N N 168 
GLN   CG  HG2  sing N N 169 
GLN   CG  HG3  sing N N 170 
GLN   CD  OE1  doub N N 171 
GLN   CD  NE2  sing N N 172 
GLN   NE2 HE21 sing N N 173 
GLN   NE2 HE22 sing N N 174 
GLN   OXT HXT  sing N N 175 
GLU   N   CA   sing N N 176 
GLU   N   H    sing N N 177 
GLU   N   H2   sing N N 178 
GLU   CA  C    sing N N 179 
GLU   CA  CB   sing N N 180 
GLU   CA  HA   sing N N 181 
GLU   C   O    doub N N 182 
GLU   C   OXT  sing N N 183 
GLU   CB  CG   sing N N 184 
GLU   CB  HB2  sing N N 185 
GLU   CB  HB3  sing N N 186 
GLU   CG  CD   sing N N 187 
GLU   CG  HG2  sing N N 188 
GLU   CG  HG3  sing N N 189 
GLU   CD  OE1  doub N N 190 
GLU   CD  OE2  sing N N 191 
GLU   OE2 HE2  sing N N 192 
GLU   OXT HXT  sing N N 193 
GLY   N   CA   sing N N 194 
GLY   N   H    sing N N 195 
GLY   N   H2   sing N N 196 
GLY   CA  C    sing N N 197 
GLY   CA  HA2  sing N N 198 
GLY   CA  HA3  sing N N 199 
GLY   C   O    doub N N 200 
GLY   C   OXT  sing N N 201 
GLY   OXT HXT  sing N N 202 
HIS   N   CA   sing N N 203 
HIS   N   H    sing N N 204 
HIS   N   H2   sing N N 205 
HIS   CA  C    sing N N 206 
HIS   CA  CB   sing N N 207 
HIS   CA  HA   sing N N 208 
HIS   C   O    doub N N 209 
HIS   C   OXT  sing N N 210 
HIS   CB  CG   sing N N 211 
HIS   CB  HB2  sing N N 212 
HIS   CB  HB3  sing N N 213 
HIS   CG  ND1  sing Y N 214 
HIS   CG  CD2  doub Y N 215 
HIS   ND1 CE1  doub Y N 216 
HIS   ND1 HD1  sing N N 217 
HIS   CD2 NE2  sing Y N 218 
HIS   CD2 HD2  sing N N 219 
HIS   CE1 NE2  sing Y N 220 
HIS   CE1 HE1  sing N N 221 
HIS   NE2 HE2  sing N N 222 
HIS   OXT HXT  sing N N 223 
HOH   O   H1   sing N N 224 
HOH   O   H2   sing N N 225 
ILE   N   CA   sing N N 226 
ILE   N   H    sing N N 227 
ILE   N   H2   sing N N 228 
ILE   CA  C    sing N N 229 
ILE   CA  CB   sing N N 230 
ILE   CA  HA   sing N N 231 
ILE   C   O    doub N N 232 
ILE   C   OXT  sing N N 233 
ILE   CB  CG1  sing N N 234 
ILE   CB  CG2  sing N N 235 
ILE   CB  HB   sing N N 236 
ILE   CG1 CD1  sing N N 237 
ILE   CG1 HG12 sing N N 238 
ILE   CG1 HG13 sing N N 239 
ILE   CG2 HG21 sing N N 240 
ILE   CG2 HG22 sing N N 241 
ILE   CG2 HG23 sing N N 242 
ILE   CD1 HD11 sing N N 243 
ILE   CD1 HD12 sing N N 244 
ILE   CD1 HD13 sing N N 245 
ILE   OXT HXT  sing N N 246 
LEU   N   CA   sing N N 247 
LEU   N   H    sing N N 248 
LEU   N   H2   sing N N 249 
LEU   CA  C    sing N N 250 
LEU   CA  CB   sing N N 251 
LEU   CA  HA   sing N N 252 
LEU   C   O    doub N N 253 
LEU   C   OXT  sing N N 254 
LEU   CB  CG   sing N N 255 
LEU   CB  HB2  sing N N 256 
LEU   CB  HB3  sing N N 257 
LEU   CG  CD1  sing N N 258 
LEU   CG  CD2  sing N N 259 
LEU   CG  HG   sing N N 260 
LEU   CD1 HD11 sing N N 261 
LEU   CD1 HD12 sing N N 262 
LEU   CD1 HD13 sing N N 263 
LEU   CD2 HD21 sing N N 264 
LEU   CD2 HD22 sing N N 265 
LEU   CD2 HD23 sing N N 266 
LEU   OXT HXT  sing N N 267 
LYS   N   CA   sing N N 268 
LYS   N   H    sing N N 269 
LYS   N   H2   sing N N 270 
LYS   CA  C    sing N N 271 
LYS   CA  CB   sing N N 272 
LYS   CA  HA   sing N N 273 
LYS   C   O    doub N N 274 
LYS   C   OXT  sing N N 275 
LYS   CB  CG   sing N N 276 
LYS   CB  HB2  sing N N 277 
LYS   CB  HB3  sing N N 278 
LYS   CG  CD   sing N N 279 
LYS   CG  HG2  sing N N 280 
LYS   CG  HG3  sing N N 281 
LYS   CD  CE   sing N N 282 
LYS   CD  HD2  sing N N 283 
LYS   CD  HD3  sing N N 284 
LYS   CE  NZ   sing N N 285 
LYS   CE  HE2  sing N N 286 
LYS   CE  HE3  sing N N 287 
LYS   NZ  HZ1  sing N N 288 
LYS   NZ  HZ2  sing N N 289 
LYS   NZ  HZ3  sing N N 290 
LYS   OXT HXT  sing N N 291 
MET   N   CA   sing N N 292 
MET   N   H    sing N N 293 
MET   N   H2   sing N N 294 
MET   CA  C    sing N N 295 
MET   CA  CB   sing N N 296 
MET   CA  HA   sing N N 297 
MET   C   O    doub N N 298 
MET   C   OXT  sing N N 299 
MET   CB  CG   sing N N 300 
MET   CB  HB2  sing N N 301 
MET   CB  HB3  sing N N 302 
MET   CG  SD   sing N N 303 
MET   CG  HG2  sing N N 304 
MET   CG  HG3  sing N N 305 
MET   SD  CE   sing N N 306 
MET   CE  HE1  sing N N 307 
MET   CE  HE2  sing N N 308 
MET   CE  HE3  sing N N 309 
MET   OXT HXT  sing N N 310 
PHE   N   CA   sing N N 311 
PHE   N   H    sing N N 312 
PHE   N   H2   sing N N 313 
PHE   CA  C    sing N N 314 
PHE   CA  CB   sing N N 315 
PHE   CA  HA   sing N N 316 
PHE   C   O    doub N N 317 
PHE   C   OXT  sing N N 318 
PHE   CB  CG   sing N N 319 
PHE   CB  HB2  sing N N 320 
PHE   CB  HB3  sing N N 321 
PHE   CG  CD1  doub Y N 322 
PHE   CG  CD2  sing Y N 323 
PHE   CD1 CE1  sing Y N 324 
PHE   CD1 HD1  sing N N 325 
PHE   CD2 CE2  doub Y N 326 
PHE   CD2 HD2  sing N N 327 
PHE   CE1 CZ   doub Y N 328 
PHE   CE1 HE1  sing N N 329 
PHE   CE2 CZ   sing Y N 330 
PHE   CE2 HE2  sing N N 331 
PHE   CZ  HZ   sing N N 332 
PHE   OXT HXT  sing N N 333 
PRO   N   CA   sing N N 334 
PRO   N   CD   sing N N 335 
PRO   N   H    sing N N 336 
PRO   CA  C    sing N N 337 
PRO   CA  CB   sing N N 338 
PRO   CA  HA   sing N N 339 
PRO   C   O    doub N N 340 
PRO   C   OXT  sing N N 341 
PRO   CB  CG   sing N N 342 
PRO   CB  HB2  sing N N 343 
PRO   CB  HB3  sing N N 344 
PRO   CG  CD   sing N N 345 
PRO   CG  HG2  sing N N 346 
PRO   CG  HG3  sing N N 347 
PRO   CD  HD2  sing N N 348 
PRO   CD  HD3  sing N N 349 
PRO   OXT HXT  sing N N 350 
SER   N   CA   sing N N 351 
SER   N   H    sing N N 352 
SER   N   H2   sing N N 353 
SER   CA  C    sing N N 354 
SER   CA  CB   sing N N 355 
SER   CA  HA   sing N N 356 
SER   C   O    doub N N 357 
SER   C   OXT  sing N N 358 
SER   CB  OG   sing N N 359 
SER   CB  HB2  sing N N 360 
SER   CB  HB3  sing N N 361 
SER   OG  HG   sing N N 362 
SER   OXT HXT  sing N N 363 
THR   N   CA   sing N N 364 
THR   N   H    sing N N 365 
THR   N   H2   sing N N 366 
THR   CA  C    sing N N 367 
THR   CA  CB   sing N N 368 
THR   CA  HA   sing N N 369 
THR   C   O    doub N N 370 
THR   C   OXT  sing N N 371 
THR   CB  OG1  sing N N 372 
THR   CB  CG2  sing N N 373 
THR   CB  HB   sing N N 374 
THR   OG1 HG1  sing N N 375 
THR   CG2 HG21 sing N N 376 
THR   CG2 HG22 sing N N 377 
THR   CG2 HG23 sing N N 378 
THR   OXT HXT  sing N N 379 
TYR   N   CA   sing N N 380 
TYR   N   H    sing N N 381 
TYR   N   H2   sing N N 382 
TYR   CA  C    sing N N 383 
TYR   CA  CB   sing N N 384 
TYR   CA  HA   sing N N 385 
TYR   C   O    doub N N 386 
TYR   C   OXT  sing N N 387 
TYR   CB  CG   sing N N 388 
TYR   CB  HB2  sing N N 389 
TYR   CB  HB3  sing N N 390 
TYR   CG  CD1  doub Y N 391 
TYR   CG  CD2  sing Y N 392 
TYR   CD1 CE1  sing Y N 393 
TYR   CD1 HD1  sing N N 394 
TYR   CD2 CE2  doub Y N 395 
TYR   CD2 HD2  sing N N 396 
TYR   CE1 CZ   doub Y N 397 
TYR   CE1 HE1  sing N N 398 
TYR   CE2 CZ   sing Y N 399 
TYR   CE2 HE2  sing N N 400 
TYR   CZ  OH   sing N N 401 
TYR   OH  HH   sing N N 402 
TYR   OXT HXT  sing N N 403 
VAL   N   CA   sing N N 404 
VAL   N   H    sing N N 405 
VAL   N   H2   sing N N 406 
VAL   CA  C    sing N N 407 
VAL   CA  CB   sing N N 408 
VAL   CA  HA   sing N N 409 
VAL   C   O    doub N N 410 
VAL   C   OXT  sing N N 411 
VAL   CB  CG1  sing N N 412 
VAL   CB  CG2  sing N N 413 
VAL   CB  HB   sing N N 414 
VAL   CG1 HG11 sing N N 415 
VAL   CG1 HG12 sing N N 416 
VAL   CG1 HG13 sing N N 417 
VAL   CG2 HG21 sing N N 418 
VAL   CG2 HG22 sing N N 419 
VAL   CG2 HG23 sing N N 420 
VAL   OXT HXT  sing N N 421 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121054 1 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121052 2 
'Japan Society for the Promotion of Science (JSPS)'        Japan 15H02896      3 
'Japan Society for the Promotion of Science (JSPS)'        Japan 16K13044      4 
'Japan Society for the Promotion of Science (JSPS)'        Japan 18H03190      5 
'Japan Society for the Promotion of Science (JSPS)'        Japan 21H03354      6 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6KXY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YWV 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019990 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016262 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010252 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LYS   A 1 8   ? -9.28600  -9.18600  -2.17400  1.000 67.22282 ? 204 LYS   A N   1 
ATOM   2    C CA  . LYS   A 1 8   ? -10.39700 -8.26400  -1.93400  1.000 71.83245 ? 204 LYS   A CA  1 
ATOM   3    C C   . LYS   A 1 8   ? -10.76500 -7.62400  -3.26300  1.000 69.88487 ? 204 LYS   A C   1 
ATOM   4    O O   . LYS   A 1 8   ? -11.65900 -8.07400  -3.98300  1.000 73.22553 ? 204 LYS   A O   1 
ATOM   5    C CB  . LYS   A 1 8   ? -10.03000 -7.16700  -0.91500  1.000 70.31114 ? 204 LYS   A CB  1 
ATOM   6    C CG  . LYS   A 1 8   ? -9.65700  -7.61700  0.49900   1.000 75.98196 ? 204 LYS   A CG  1 
ATOM   7    C CD  . LYS   A 1 8   ? -8.39200  -8.47900  0.56000   1.000 74.37228 ? 204 LYS   A CD  1 
ATOM   8    C CE  . LYS   A 1 8   ? -7.17900  -7.75200  -0.00700  1.000 78.73795 ? 204 LYS   A CE  1 
ATOM   9    N NZ  . LYS   A 1 8   ? -6.02500  -8.68700  -0.10600  1.000 81.80061 ? 204 LYS   A NZ  1 
ATOM   10   N N   . SER   A 1 9   ? -10.05800 -6.53600  -3.55200  1.000 67.12649 ? 205 SER   A N   1 
ATOM   11   C CA  . SER   A 1 9   ? -9.95100  -5.95900  -4.88000  1.000 62.75037 ? 205 SER   A CA  1 
ATOM   12   C C   . SER   A 1 9   ? -8.62000  -6.32000  -5.52400  1.000 59.29420 ? 205 SER   A C   1 
ATOM   13   O O   . SER   A 1 9   ? -8.14400  -5.60100  -6.41200  1.000 57.83453 ? 205 SER   A O   1 
ATOM   14   C CB  . SER   A 1 9   ? -10.10900 -4.44400  -4.79000  1.000 62.85910 ? 205 SER   A CB  1 
ATOM   15   O OG  . SER   A 1 9   ? -9.18000  -3.93800  -3.84800  1.000 61.58147 ? 205 SER   A OG  1 
ATOM   16   N N   . LEU   A 1 10  ? -7.98900  -7.39300  -5.04100  1.000 57.13072 ? 206 LEU   A N   1 
ATOM   17   C CA  . LEU   A 1 10  ? -6.68900  -7.81400  -5.54700  1.000 52.96450 ? 206 LEU   A CA  1 
ATOM   18   C C   . LEU   A 1 10  ? -6.71000  -7.94000  -7.06000  1.000 44.83860 ? 206 LEU   A C   1 
ATOM   19   O O   . LEU   A 1 10  ? -5.80600  -7.45200  -7.74700  1.000 44.95008 ? 206 LEU   A O   1 
ATOM   20   C CB  . LEU   A 1 10  ? -6.28800  -9.14200  -4.89200  1.000 51.44936 ? 206 LEU   A CB  1 
ATOM   21   C CG  . LEU   A 1 10  ? -5.10700  -9.91400  -5.48200  1.000 50.74379 ? 206 LEU   A CG  1 
ATOM   22   C CD1 . LEU   A 1 10  ? -3.81400  -9.12800  -5.30700  1.000 47.08488 ? 206 LEU   A CD1 1 
ATOM   23   C CD2 . LEU   A 1 10  ? -4.99300  -11.31000 -4.84800  1.000 44.66429 ? 206 LEU   A CD2 1 
ATOM   24   N N   . ALA   A 1 11  ? -7.76800  -8.54400  -7.60300  1.000 46.14024 ? 207 ALA   A N   1 
ATOM   25   C CA  . ALA   A 1 11  ? -7.82500  -8.76100  -9.04200  1.000 46.63824 ? 207 ALA   A CA  1 
ATOM   26   C C   . ALA   A 1 11  ? -7.95500  -7.44900  -9.80200  1.000 47.35197 ? 207 ALA   A C   1 
ATOM   27   O O   . ALA   A 1 11  ? -7.44200  -7.33400  -10.92000 1.000 41.62588 ? 207 ALA   A O   1 
ATOM   28   C CB  . ALA   A 1 11  ? -8.98300  -9.69100  -9.39200  1.000 40.14905 ? 207 ALA   A CB  1 
ATOM   29   N N   . LYS   A 1 12  ? -8.65200  -6.46600  -9.22800  1.000 46.66562 ? 208 LYS   A N   1 
ATOM   30   C CA  . LYS   A 1 12  ? -8.77300  -5.16800  -9.88100  1.000 48.15045 ? 208 LYS   A CA  1 
ATOM   31   C C   . LYS   A 1 12  ? -7.43800  -4.45000  -9.87600  1.000 42.38289 ? 208 LYS   A C   1 
ATOM   32   O O   . LYS   A 1 12  ? -7.03200  -3.87300  -10.88800 1.000 45.51577 ? 208 LYS   A O   1 
ATOM   33   C CB  . LYS   A 1 12  ? -9.84700  -4.32000  -9.18500  1.000 50.93462 ? 208 LYS   A CB  1 
ATOM   34   C CG  . LYS   A 1 12  ? -9.59600  -2.80700  -9.22200  1.000 59.22921 ? 208 LYS   A CG  1 
ATOM   35   C CD  . LYS   A 1 12  ? -10.90000 -1.99400  -9.36200  1.000 61.57893 ? 208 LYS   A CD  1 
ATOM   36   C CE  . LYS   A 1 12  ? -11.98400 -2.49400  -8.39700  1.000 62.57909 ? 208 LYS   A CE  1 
ATOM   37   N NZ  . LYS   A 1 12  ? -13.34400 -1.95600  -8.69800  1.000 63.16264 ? 208 LYS   A NZ  1 
ATOM   38   N N   . ARG   A 1 13  ? -6.73500  -4.49700  -8.74700  1.000 41.33255 ? 209 ARG   A N   1 
ATOM   39   C CA  . ARG   A 1 13  ? -5.41400  -3.88900  -8.66300  1.000 42.89888 ? 209 ARG   A CA  1 
ATOM   40   C C   . ARG   A 1 13  ? -4.43800  -4.50600  -9.66500  1.000 42.12708 ? 209 ARG   A C   1 
ATOM   41   O O   . ARG   A 1 13  ? -3.60500  -3.80200  -10.24800 1.000 39.62407 ? 209 ARG   A O   1 
ATOM   42   C CB  . ARG   A 1 13  ? -4.87500  -4.04700  -7.24800  1.000 44.47072 ? 209 ARG   A CB  1 
ATOM   43   C CG  . ARG   A 1 13  ? -5.75700  -3.39100  -6.18500  1.000 56.51200 ? 209 ARG   A CG  1 
ATOM   44   C CD  . ARG   A 1 13  ? -4.94300  -2.46200  -5.34400  1.000 57.61765 ? 209 ARG   A CD  1 
ATOM   45   N NE  . ARG   A 1 13  ? -4.49800  -3.09700  -4.11100  1.000 63.79310 ? 209 ARG   A NE  1 
ATOM   46   C CZ  . ARG   A 1 13  ? -3.36800  -2.78600  -3.49000  1.000 64.55790 ? 209 ARG   A CZ  1 
ATOM   47   N NH1 . ARG   A 1 13  ? -3.05000  -3.32100  -2.32000  1.000 64.06469 ? 209 ARG   A NH1 1 
ATOM   48   N NH2 . ARG   A 1 13  ? -2.53600  -1.91400  -4.06200  1.000 62.70860 ? 209 ARG   A NH2 1 
ATOM   49   N N   . ILE   A 1 14  ? -4.49800  -5.82600  -9.86100  1.000 39.93656 ? 210 ILE   A N   1 
ATOM   50   C CA  . ILE   A 1 14  ? -3.57400  -6.45300  -10.80600 1.000 35.52128 ? 210 ILE   A CA  1 
ATOM   51   C C   . ILE   A 1 14  ? -3.93700  -6.08600  -12.24100 1.000 34.39237 ? 210 ILE   A C   1 
ATOM   52   O O   . ILE   A 1 14  ? -3.05700  -5.81200  -13.06400 1.000 36.26922 ? 210 ILE   A O   1 
ATOM   53   C CB  . ILE   A 1 14  ? -3.54500  -7.97700  -10.58600 1.000 33.30679 ? 210 ILE   A CB  1 
ATOM   54   C CG1 . ILE   A 1 14  ? -2.74600  -8.27900  -9.31700  1.000 35.18440 ? 210 ILE   A CG1 1 
ATOM   55   C CG2 . ILE   A 1 14  ? -2.94800  -8.67600  -11.81200 1.000 28.30502 ? 210 ILE   A CG2 1 
ATOM   56   C CD1 . ILE   A 1 14  ? -2.77300  -9.74200  -8.88300  1.000 38.82695 ? 210 ILE   A CD1 1 
ATOM   57   N N   . TYR   A 1 15  ? -5.23100  -6.08200  -12.56800 1.000 32.04080 ? 211 TYR   A N   1 
ATOM   58   C CA  . TYR   A 1 15  ? -5.65800  -5.69100  -13.90900 1.000 37.00475 ? 211 TYR   A CA  1 
ATOM   59   C C   . TYR   A 1 15  ? -5.25000  -4.25000  -14.21200 1.000 40.51448 ? 211 TYR   A C   1 
ATOM   60   O O   . TYR   A 1 15  ? -4.74200  -3.94500  -15.30100 1.000 37.64760 ? 211 TYR   A O   1 
ATOM   61   C CB  . TYR   A 1 15  ? -7.17200  -5.85700  -14.03700 1.000 35.68847 ? 211 TYR   A CB  1 
ATOM   62   C CG  . TYR   A 1 15  ? -7.70200  -5.58200  -15.41700 1.000 40.78000 ? 211 TYR   A CG  1 
ATOM   63   C CD1 . TYR   A 1 15  ? -9.00000  -5.11600  -15.61100 1.000 41.69382 ? 211 TYR   A CD1 1 
ATOM   64   C CD2 . TYR   A 1 15  ? -6.91600  -5.81300  -16.54000 1.000 38.05367 ? 211 TYR   A CD2 1 
ATOM   65   C CE1 . TYR   A 1 15  ? -9.49000  -4.88200  -16.91000 1.000 40.77789 ? 211 TYR   A CE1 1 
ATOM   66   C CE2 . TYR   A 1 15  ? -7.38600  -5.57700  -17.82200 1.000 36.87221 ? 211 TYR   A CE2 1 
ATOM   67   C CZ  . TYR   A 1 15  ? -8.67000  -5.11900  -18.00600 1.000 43.50882 ? 211 TYR   A CZ  1 
ATOM   68   O OH  . TYR   A 1 15  ? -9.12400  -4.88800  -19.29500 1.000 47.56677 ? 211 TYR   A OH  1 
ATOM   69   N N   . GLU   A 1 16  ? -5.44400  -3.35300  -13.25000 1.000 38.63928 ? 212 GLU   A N   1 
ATOM   70   C CA  . GLU   A 1 16  ? -5.07600  -1.96200  -13.48000 1.000 41.06646 ? 212 GLU   A CA  1 
ATOM   71   C C   . GLU   A 1 16  ? -3.56900  -1.79800  -13.62900 1.000 39.78422 ? 212 GLU   A C   1 
ATOM   72   O O   . GLU   A 1 16  ? -3.10600  -0.98800  -14.43600 1.000 38.40565 ? 212 GLU   A O   1 
ATOM   73   C CB  . GLU   A 1 16  ? -5.60400  -1.09800  -12.33400 1.000 42.69906 ? 212 GLU   A CB  1 
ATOM   74   C CG  . GLU   A 1 16  ? -7.09900  -0.80900  -12.46100 1.000 47.40055 ? 212 GLU   A CG  1 
ATOM   75   C CD  . GLU   A 1 16  ? -7.69100  -0.23700  -11.19000 1.000 57.62720 ? 212 GLU   A CD  1 
ATOM   76   O OE1 . GLU   A 1 16  ? -6.91000  0.18300   -10.30500 1.000 52.93191 ? 212 GLU   A OE1 1 
ATOM   77   O OE2 . GLU   A 1 16  ? -8.93800  -0.19800  -11.08800 1.000 60.04575 ? 212 GLU   A OE2 1 
ATOM   78   N N   . ALA   A 1 17  ? -2.78500  -2.53100  -12.84200 1.000 34.31164 ? 213 ALA   A N   1 
ATOM   79   C CA  . ALA   A 1 17  ? -1.33900  -2.45500  -12.99700 1.000 36.18230 ? 213 ALA   A CA  1 
ATOM   80   C C   . ALA   A 1 17  ? -0.92200  -2.93600  -14.37600 1.000 35.53160 ? 213 ALA   A C   1 
ATOM   81   O O   . ALA   A 1 17  ? 0.01100   -2.39100  -14.98100 1.000 37.62905 ? 213 ALA   A O   1 
ATOM   82   C CB  . ALA   A 1 17  ? -0.64200  -3.27100  -11.89800 1.000 37.06359 ? 213 ALA   A CB  1 
ATOM   83   N N   . TYR   A 1 18  ? -1.61500  -3.95100  -14.89500 1.000 34.90579 ? 214 TYR   A N   1 
ATOM   84   C CA  . TYR   A 1 18  ? -1.32800  -4.45800  -16.23500 1.000 36.33659 ? 214 TYR   A CA  1 
ATOM   85   C C   . TYR   A 1 18  ? -1.63900  -3.40700  -17.29300 1.000 36.00613 ? 214 TYR   A C   1 
ATOM   86   O O   . TYR   A 1 18  ? -0.82400  -3.15200  -18.18700 1.000 33.31538 ? 214 TYR   A O   1 
ATOM   87   C CB  . TYR   A 1 18  ? -2.15200  -5.72100  -16.46000 1.000 35.69842 ? 214 TYR   A CB  1 
ATOM   88   C CG  . TYR   A 1 18  ? -2.16700  -6.35800  -17.83300 1.000 37.15735 ? 214 TYR   A CG  1 
ATOM   89   C CD1 . TYR   A 1 18  ? -3.08300  -5.95600  -18.80000 1.000 37.58579 ? 214 TYR   A CD1 1 
ATOM   90   C CD2 . TYR   A 1 18  ? -1.33500  -7.43600  -18.12500 1.000 36.18631 ? 214 TYR   A CD2 1 
ATOM   91   C CE1 . TYR   A 1 18  ? -3.14400  -6.57400  -20.03500 1.000 40.01194 ? 214 TYR   A CE1 1 
ATOM   92   C CE2 . TYR   A 1 18  ? -1.38100  -8.06000  -19.37900 1.000 36.23132 ? 214 TYR   A CE2 1 
ATOM   93   C CZ  . TYR   A 1 18  ? -2.28700  -7.62600  -20.31800 1.000 38.25834 ? 214 TYR   A CZ  1 
ATOM   94   O OH  . TYR   A 1 18  ? -2.35100  -8.22900  -21.55300 1.000 44.98773 ? 214 TYR   A OH  1 
ATOM   95   N N   . LEU   A 1 19  ? -2.83300  -2.80900  -17.22200 1.000 35.51314 ? 215 LEU   A N   1 
ATOM   96   C CA  . LEU   A 1 19  ? -3.19700  -1.76800  -18.17900 1.000 35.43119 ? 215 LEU   A CA  1 
ATOM   97   C C   . LEU   A 1 19  ? -2.26400  -0.57600  -18.08200 1.000 38.90010 ? 215 LEU   A C   1 
ATOM   98   O O   . LEU   A 1 19  ? -1.96700  0.05900   -19.09600 1.000 40.68449 ? 215 LEU   A O   1 
ATOM   99   C CB  . LEU   A 1 19  ? -4.64000  -1.32500  -17.96100 1.000 39.14615 ? 215 LEU   A CB  1 
ATOM   100  C CG  . LEU   A 1 19  ? -5.68200  -2.36300  -18.39000 1.000 39.33912 ? 215 LEU   A CG  1 
ATOM   101  C CD1 . LEU   A 1 19  ? -7.11800  -1.87600  -18.16000 1.000 44.16018 ? 215 LEU   A CD1 1 
ATOM   102  C CD2 . LEU   A 1 19  ? -5.45600  -2.73700  -19.83600 1.000 39.47545 ? 215 LEU   A CD2 1 
ATOM   103  N N   . LYS   A 1 20  ? -1.78000  -0.25900  -16.88500 1.000 35.87407 ? 216 LYS   A N   1 
ATOM   104  C CA  . LYS   A 1 20  ? -0.89700  0.88800   -16.76600 1.000 40.61050 ? 216 LYS   A CA  1 
ATOM   105  C C   . LYS   A 1 20  ? 0.50200   0.59200   -17.28900 1.000 45.22527 ? 216 LYS   A C   1 
ATOM   106  O O   . LYS   A 1 20  ? 1.14500   1.49700   -17.82700 1.000 42.88829 ? 216 LYS   A O   1 
ATOM   107  C CB  . LYS   A 1 20  ? -0.83900  1.36100   -15.30900 1.000 39.66853 ? 216 LYS   A CB  1 
ATOM   108  C CG  . LYS   A 1 20  ? 0.48600   1.99200   -14.89500 1.000 48.61949 ? 216 LYS   A CG  1 
ATOM   109  C CD  . LYS   A 1 20  ? 0.43600   2.49500   -13.44900 1.000 52.79129 ? 216 LYS   A CD  1 
ATOM   110  C CE  . LYS   A 1 20  ? 1.35100   3.68800   -13.23100 1.000 53.07097 ? 216 LYS   A CE  1 
ATOM   111  N NZ  . LYS   A 1 20  ? 2.68700   3.32400   -12.66100 1.000 52.23864 ? 216 LYS   A NZ  1 
ATOM   112  N N   . ASN   A 1 21  ? 0.98900   -0.65800  -17.19200 1.000 33.87932 ? 217 ASN   A N   1 
ATOM   113  C CA  . ASN   A 1 21  ? 2.41300   -0.87600  -17.40100 1.000 37.62943 ? 217 ASN   A CA  1 
ATOM   114  C C   . ASN   A 1 21  ? 2.80800   -1.49400  -18.74400 1.000 37.29524 ? 217 ASN   A C   1 
ATOM   115  O O   . ASN   A 1 21  ? 3.99400   -1.45200  -19.08300 1.000 39.12135 ? 217 ASN   A O   1 
ATOM   116  C CB  . ASN   A 1 21  ? 2.97600   -1.72000  -16.25200 1.000 37.27039 ? 217 ASN   A CB  1 
ATOM   117  C CG  . ASN   A 1 21  ? 3.17800   -0.89100  -14.98800 1.000 42.23441 ? 217 ASN   A CG  1 
ATOM   118  O OD1 . ASN   A 1 21  ? 4.08600   -0.06600  -14.92200 1.000 43.23450 ? 217 ASN   A OD1 1 
ATOM   119  N ND2 . ASN   A 1 21  ? 2.30500   -1.08600  -13.99300 1.000 41.33625 ? 217 ASN   A ND2 1 
ATOM   120  N N   . PHE   A 1 22  ? 1.88800   -2.07000  -19.51600 1.000 33.78503 ? 218 PHE   A N   1 
ATOM   121  C CA  . PHE   A 1 22  ? 2.24800   -2.73500  -20.76900 1.000 37.96604 ? 218 PHE   A CA  1 
ATOM   122  C C   . PHE   A 1 22  ? 1.74700   -1.90800  -21.94300 1.000 37.52399 ? 218 PHE   A C   1 
ATOM   123  O O   . PHE   A 1 22  ? 0.54800   -1.61100  -22.03700 1.000 38.87479 ? 218 PHE   A O   1 
ATOM   124  C CB  . PHE   A 1 22  ? 1.69900   -4.16600  -20.82400 1.000 32.84640 ? 218 PHE   A CB  1 
ATOM   125  C CG  . PHE   A 1 22  ? 2.30600   -5.04900  -19.78600 1.000 32.96547 ? 218 PHE   A CG  1 
ATOM   126  C CD1 . PHE   A 1 22  ? 3.62200   -5.46000  -19.90000 1.000 36.57446 ? 218 PHE   A CD1 1 
ATOM   127  C CD2 . PHE   A 1 22  ? 1.59100   -5.41300  -18.65400 1.000 35.07871 ? 218 PHE   A CD2 1 
ATOM   128  C CE1 . PHE   A 1 22  ? 4.21100   -6.24200  -18.92400 1.000 33.75566 ? 218 PHE   A CE1 1 
ATOM   129  C CE2 . PHE   A 1 22  ? 2.19000   -6.20300  -17.65600 1.000 33.74364 ? 218 PHE   A CE2 1 
ATOM   130  C CZ  . PHE   A 1 22  ? 3.49900   -6.60700  -17.80600 1.000 30.29168 ? 218 PHE   A CZ  1 
ATOM   131  N N   . ASN   A 1 23  ? 2.66300   -1.54600  -22.84000 1.000 42.57275 ? 219 ASN   A N   1 
ATOM   132  C CA  . ASN   A 1 23  ? 2.25900   -0.74800  -23.99000 1.000 42.33708 ? 219 ASN   A CA  1 
ATOM   133  C C   . ASN   A 1 23  ? 1.40000   -1.56400  -24.94400 1.000 43.86305 ? 219 ASN   A C   1 
ATOM   134  O O   . ASN   A 1 23  ? 0.50200   -1.02500  -25.59800 1.000 41.59708 ? 219 ASN   A O   1 
ATOM   135  C CB  . ASN   A 1 23  ? 3.48800   -0.17000  -24.70600 1.000 42.10955 ? 219 ASN   A CB  1 
ATOM   136  C CG  . ASN   A 1 23  ? 4.27900   -1.21200  -25.48600 1.000 49.57348 ? 219 ASN   A CG  1 
ATOM   137  O OD1 . ASN   A 1 23  ? 3.90600   -1.60400  -26.60500 1.000 47.17429 ? 219 ASN   A OD1 1 
ATOM   138  N ND2 . ASN   A 1 23  ? 5.40400   -1.63000  -24.92200 1.000 48.54124 ? 219 ASN   A ND2 1 
ATOM   139  N N   . MET   A 1 24  ? 1.64300   -2.86000  -25.03800 1.000 39.74634 ? 220 MET   A N   1 
ATOM   140  C CA  . MET   A 1 24  ? 0.82800   -3.69200  -25.89700 1.000 41.21627 ? 220 MET   A CA  1 
ATOM   141  C C   . MET   A 1 24  ? 0.00400   -4.63600  -25.03700 1.000 42.63709 ? 220 MET   A C   1 
ATOM   142  O O   . MET   A 1 24  ? 0.46000   -5.08900  -23.97800 1.000 41.39101 ? 220 MET   A O   1 
ATOM   143  C CB  . MET   A 1 24  ? 1.68100   -4.46200  -26.90000 1.000 42.29682 ? 220 MET   A CB  1 
ATOM   144  C CG  . MET   A 1 24  ? 0.82800   -5.31700  -27.80500 1.000 45.06337 ? 220 MET   A CG  1 
ATOM   145  S SD  . MET   A 1 24  ? -0.04600  -4.36600  -29.07800 1.000 52.74547 ? 220 MET   A SD  1 
ATOM   146  C CE  . MET   A 1 24  ? 1.24900   -3.27400  -29.67800 1.000 45.79732 ? 220 MET   A CE  1 
ATOM   147  N N   . ASN   A 1 25  ? -1.23600  -4.86500  -25.45900 1.000 38.99495 ? 221 ASN   A N   1 
ATOM   148  C CA  . ASN   A 1 25  ? -2.08600  -5.85700  -24.82500 1.000 41.23000 ? 221 ASN   A CA  1 
ATOM   149  C C   . ASN   A 1 25  ? -2.97100  -6.44000  -25.90500 1.000 41.43025 ? 221 ASN   A C   1 
ATOM   150  O O   . ASN   A 1 25  ? -2.88100  -6.06100  -27.07600 1.000 40.31139 ? 221 ASN   A O   1 
ATOM   151  C CB  . ASN   A 1 25  ? -2.90800  -5.27400  -23.67100 1.000 35.88614 ? 221 ASN   A CB  1 
ATOM   152  C CG  . ASN   A 1 25  ? -3.71100  -4.04800  -24.07400 1.000 41.77582 ? 221 ASN   A CG  1 
ATOM   153  O OD1 . ASN   A 1 25  ? -4.23600  -3.96800  -25.17900 1.000 39.74609 ? 221 ASN   A OD1 1 
ATOM   154  N ND2 . ASN   A 1 25  ? -3.79900  -3.08200  -23.17600 1.000 42.55905 ? 221 ASN   A ND2 1 
ATOM   155  N N   . LYS   A 1 26  ? -3.85600  -7.34100  -25.49400 1.000 36.05157 ? 222 LYS   A N   1 
ATOM   156  C CA  . LYS   A 1 26  ? -4.61100  -8.11800  -26.46800 1.000 38.75962 ? 222 LYS   A CA  1 
ATOM   157  C C   . LYS   A 1 26  ? -5.66200  -7.26800  -27.17300 1.000 40.46437 ? 222 LYS   A C   1 
ATOM   158  O O   . LYS   A 1 26  ? -5.85900  -7.40100  -28.38900 1.000 38.24984 ? 222 LYS   A O   1 
ATOM   159  C CB  . LYS   A 1 26  ? -5.25500  -9.33000  -25.78300 1.000 36.96506 ? 222 LYS   A CB  1 
ATOM   160  C CG  . LYS   A 1 26  ? -5.56700  -10.44500 -26.75800 1.000 41.19616 ? 222 LYS   A CG  1 
ATOM   161  C CD  . LYS   A 1 26  ? -6.09400  -11.67100 -26.05100 1.000 42.64908 ? 222 LYS   A CD  1 
ATOM   162  C CE  . LYS   A 1 26  ? -6.46400  -12.76400 -27.06400 1.000 42.07382 ? 222 LYS   A CE  1 
ATOM   163  N NZ  . LYS   A 1 26  ? -6.78000  -14.04100 -26.35100 1.000 38.38450 ? 222 LYS   A NZ  1 
ATOM   164  N N   . VAL   A 1 27  ? -6.35400  -6.39300  -26.44000 1.000 41.96805 ? 223 VAL   A N   1 
ATOM   165  C CA  . VAL   A 1 27  ? -7.38600  -5.58300  -27.08600 1.000 43.25273 ? 223 VAL   A CA  1 
ATOM   166  C C   . VAL   A 1 27  ? -6.76300  -4.69700  -28.16700 1.000 41.01821 ? 223 VAL   A C   1 
ATOM   167  O O   . VAL   A 1 27  ? -7.21500  -4.68800  -29.31500 1.000 40.30295 ? 223 VAL   A O   1 
ATOM   168  C CB  . VAL   A 1 27  ? -8.18400  -4.77000  -26.04400 1.000 41.47385 ? 223 VAL   A CB  1 
ATOM   169  C CG1 . VAL   A 1 27  ? -7.27800  -3.93600  -25.14600 1.000 44.79424 ? 223 VAL   A CG1 1 
ATOM   170  C CG2 . VAL   A 1 27  ? -9.20000  -3.87000  -26.74500 1.000 50.88737 ? 223 VAL   A CG2 1 
ATOM   171  N N   . LYS   A 1 28  ? -5.66500  -4.00200  -27.83200 1.000 42.27808 ? 224 LYS   A N   1 
ATOM   172  C CA  . LYS   A 1 28  ? -4.96700  -3.17100  -28.81300 1.000 40.54687 ? 224 LYS   A CA  1 
ATOM   173  C C   . LYS   A 1 28  ? -4.45100  -4.00800  -29.97100 1.000 44.39617 ? 224 LYS   A C   1 
ATOM   174  O O   . LYS   A 1 28  ? -4.56500  -3.60800  -31.13700 1.000 41.23722 ? 224 LYS   A O   1 
ATOM   175  C CB  . LYS   A 1 28  ? -3.80300  -2.43500  -28.14900 1.000 42.47235 ? 224 LYS   A CB  1 
ATOM   176  C CG  . LYS   A 1 28  ? -4.20900  -1.36700  -27.13500 1.000 49.78241 ? 224 LYS   A CG  1 
ATOM   177  C CD  . LYS   A 1 28  ? -3.00100  -0.54000  -26.70800 1.000 49.50596 ? 224 LYS   A CD  1 
ATOM   178  C CE  . LYS   A 1 28  ? -3.16700  0.00600   -25.31300 1.000 52.96451 ? 224 LYS   A CE  1 
ATOM   179  N NZ  . LYS   A 1 28  ? -1.88200  0.58000   -24.83400 1.000 58.85141 ? 224 LYS   A NZ  1 
ATOM   180  N N   . ALA   A 1 29  ? -3.89800  -5.17000  -29.67000 1.000 39.88386 ? 225 ALA   A N   1 
ATOM   181  C CA  . ALA   A 1 29  ? -3.35300  -6.03300  -30.67900 1.000 39.31801 ? 225 ALA   A CA  1 
ATOM   182  C C   . ALA   A 1 29  ? -4.38200  -6.54300  -31.64700 1.000 44.38308 ? 225 ALA   A C   1 
ATOM   183  O O   . ALA   A 1 29  ? -4.15400  -6.56800  -32.81800 1.000 40.67180 ? 225 ALA   A O   1 
ATOM   184  C CB  . ALA   A 1 29  ? -2.63300  -7.17500  -30.04800 1.000 38.62175 ? 225 ALA   A CB  1 
ATOM   185  N N   . ARG   A 1 30  ? -5.53100  -6.93100  -31.14400 1.000 40.16563 ? 226 ARG   A N   1 
ATOM   186  C CA  . ARG   A 1 30  ? -6.58300  -7.42800  -31.99900 1.000 47.50505 ? 226 ARG   A CA  1 
ATOM   187  C C   . ARG   A 1 30  ? -7.17100  -6.33700  -32.87700 1.000 49.77116 ? 226 ARG   A C   1 
ATOM   188  O O   . ARG   A 1 30  ? -7.59600  -6.62000  -33.95200 1.000 54.35802 ? 226 ARG   A O   1 
ATOM   189  C CB  . ARG   A 1 30  ? -7.64700  -8.21300  -31.23500 1.000 50.50761 ? 226 ARG   A CB  1 
ATOM   190  C CG  . ARG   A 1 30  ? -7.14800  -9.48000  -30.55500 1.000 49.85951 ? 226 ARG   A CG  1 
ATOM   191  C CD  . ARG   A 1 30  ? -6.57700  -10.55900 -31.47300 1.000 56.52016 ? 226 ARG   A CD  1 
ATOM   192  N NE  . ARG   A 1 30  ? -5.34400  -11.11700 -30.92100 1.000 57.67606 ? 226 ARG   A NE  1 
ATOM   193  C CZ  . ARG   A 1 30  ? -4.69600  -12.19300 -31.35300 1.000 56.55469 ? 226 ARG   A CZ  1 
ATOM   194  N NH1 . ARG   A 1 30  ? -5.12800  -12.92300 -32.36200 1.000 51.44115 ? 226 ARG   A NH1 1 
ATOM   195  N NH2 . ARG   A 1 30  ? -3.58900  -12.54400 -30.75300 1.000 47.87593 ? 226 ARG   A NH2 1 
ATOM   196  N N   . VAL   A 1 31  ? -7.17300  -5.09600  -32.42800 1.000 47.53373 ? 227 VAL   A N   1 
ATOM   197  C CA  . VAL   A 1 31  ? -7.61600  -4.02300  -33.28400 1.000 50.37644 ? 227 VAL   A CA  1 
ATOM   198  C C   . VAL   A 1 31  ? -6.70800  -3.99400  -34.51500 1.000 51.99528 ? 227 VAL   A C   1 
ATOM   199  O O   . VAL   A 1 31  ? -7.19500  -3.93500  -35.60600 1.000 58.61791 ? 227 VAL   A O   1 
ATOM   200  C CB  . VAL   A 1 31  ? -7.56900  -2.66400  -32.59900 1.000 50.64942 ? 227 VAL   A CB  1 
ATOM   201  C CG1 . VAL   A 1 31  ? -7.63100  -1.56900  -33.63000 1.000 55.44079 ? 227 VAL   A CG1 1 
ATOM   202  C CG2 . VAL   A 1 31  ? -8.70800  -2.50600  -31.62200 1.000 52.32251 ? 227 VAL   A CG2 1 
ATOM   203  N N   . ILE   A 1 32  ? -5.39800  -4.10600  -34.33100 1.000 49.61444 ? 228 ILE   A N   1 
ATOM   204  C CA  . ILE   A 1 32  ? -4.46300  -4.09600  -35.45400 1.000 45.32789 ? 228 ILE   A CA  1 
ATOM   205  C C   . ILE   A 1 32  ? -4.53200  -5.40000  -36.23800 1.000 52.33589 ? 228 ILE   A C   1 
ATOM   206  O O   . ILE   A 1 32  ? -4.41000  -5.40400  -37.47000 1.000 50.69990 ? 228 ILE   A O   1 
ATOM   207  C CB  . ILE   A 1 32  ? -3.02700  -3.83500  -34.96300 1.000 46.30695 ? 228 ILE   A CB  1 
ATOM   208  C CG1 . ILE   A 1 32  ? -2.91800  -2.49100  -34.23500 1.000 39.65827 ? 228 ILE   A CG1 1 
ATOM   209  C CG2 . ILE   A 1 32  ? -2.05300  -3.91500  -36.12900 1.000 43.46061 ? 228 ILE   A CG2 1 
ATOM   210  C CD1 . ILE   A 1 32  ? -1.76600  -2.43500  -33.23900 1.000 32.95451 ? 228 ILE   A CD1 1 
ATOM   211  N N   . LEU   A 1 33  ? -4.66300  -6.53100  -35.54500 1.000 48.51732 ? 229 LEU   A N   1 
ATOM   212  C CA  . LEU   A 1 33  ? -4.66300  -7.82200  -36.22800 1.000 50.55156 ? 229 LEU   A CA  1 
ATOM   213  C C   . LEU   A 1 33  ? -5.96500  -8.08700  -36.98000 1.000 54.98774 ? 229 LEU   A C   1 
ATOM   214  O O   . LEU   A 1 33  ? -6.04600  -9.07600  -37.71800 1.000 57.30232 ? 229 LEU   A O   1 
ATOM   215  C CB  . LEU   A 1 33  ? -4.40200  -8.94000  -35.21300 1.000 49.14781 ? 229 LEU   A CB  1 
ATOM   216  C CG  . LEU   A 1 33  ? -2.99700  -9.07300  -34.61300 1.000 45.30954 ? 229 LEU   A CG  1 
ATOM   217  C CD1 . LEU   A 1 33  ? -2.98700  -10.10100 -33.51000 1.000 47.55113 ? 229 LEU   A CD1 1 
ATOM   218  C CD2 . LEU   A 1 33  ? -2.01500  -9.49200  -35.68700 1.000 48.80197 ? 229 LEU   A CD2 1 
ATOM   219  N N   . SER   A 1 34  ? -6.97500  -7.23600  -36.81700 1.000 57.95462 ? 230 SER   A N   1 
ATOM   220  C CA  . SER   A 1 34  ? -8.25900  -7.41200  -37.48800 1.000 60.14079 ? 230 SER   A CA  1 
ATOM   221  C C   . SER   A 1 34  ? -8.46300  -6.37700  -38.59000 1.000 64.88287 ? 230 SER   A C   1 
ATOM   222  O O   . SER   A 1 34  ? -8.08900  -6.59200  -39.74400 1.000 70.59392 ? 230 SER   A O   1 
ATOM   223  C CB  . SER   A 1 34  ? -9.40200  -7.31600  -36.47900 1.000 60.73146 ? 230 SER   A CB  1 
ATOM   224  O OG  . SER   A 1 34  ? -9.89800  -5.98400  -36.41700 1.000 67.33092 ? 230 SER   A OG  1 
ATOM   225  N N   . PRO   A 1 41  ? -3.99100  -0.22600  -41.04300 1.000 77.04945 ? 237 PRO   A N   1 
ATOM   226  C CA  . PRO   A 1 41  ? -3.25400  -1.49500  -41.00700 1.000 71.96706 ? 237 PRO   A CA  1 
ATOM   227  C C   . PRO   A 1 41  ? -1.73700  -1.30800  -40.89600 1.000 75.17967 ? 237 PRO   A C   1 
ATOM   228  O O   . PRO   A 1 41  ? -1.22100  -0.24600  -41.26800 1.000 72.48977 ? 237 PRO   A O   1 
ATOM   229  C CB  . PRO   A 1 41  ? -3.62800  -2.16400  -42.34200 1.000 71.31316 ? 237 PRO   A CB  1 
ATOM   230  C CG  . PRO   A 1 41  ? -4.53300  -1.18400  -43.07300 1.000 76.01165 ? 237 PRO   A CG  1 
ATOM   231  C CD  . PRO   A 1 41  ? -5.07500  -0.25400  -42.03700 1.000 80.27224 ? 237 PRO   A CD  1 
ATOM   232  N N   . PRO   A 1 42  ? -1.04400  -2.32200  -40.37800 1.000 65.35635 ? 238 PRO   A N   1 
ATOM   233  C CA  . PRO   A 1 42  ? 0.41400   -2.24900  -40.24900 1.000 56.91219 ? 238 PRO   A CA  1 
ATOM   234  C C   . PRO   A 1 42  ? 1.11600   -2.64400  -41.54300 1.000 60.57291 ? 238 PRO   A C   1 
ATOM   235  O O   . PRO   A 1 42  ? 0.51200   -3.15300  -42.49000 1.000 58.56083 ? 238 PRO   A O   1 
ATOM   236  C CB  . PRO   A 1 42  ? 0.70900   -3.26200  -39.14200 1.000 52.40993 ? 238 PRO   A CB  1 
ATOM   237  C CG  . PRO   A 1 42  ? -0.35100  -4.29300  -39.31800 1.000 51.96709 ? 238 PRO   A CG  1 
ATOM   238  C CD  . PRO   A 1 42  ? -1.58300  -3.57800  -39.82300 1.000 59.03579 ? 238 PRO   A CD  1 
ATOM   239  N N   . PHE   A 1 43  ? 2.42800   -2.42500  -41.55300 1.000 53.32099 ? 239 PHE   A N   1 
ATOM   240  C CA  . PHE   A 1 43  ? 3.25100   -2.75500  -42.70000 1.000 51.60873 ? 239 PHE   A CA  1 
ATOM   241  C C   . PHE   A 1 43  ? 3.71500   -4.21000  -42.62000 1.000 51.97392 ? 239 PHE   A C   1 
ATOM   242  O O   . PHE   A 1 43  ? 4.34900   -4.61700  -41.64000 1.000 50.48612 ? 239 PHE   A O   1 
ATOM   243  C CB  . PHE   A 1 43  ? 4.45500   -1.82600  -42.76500 1.000 53.66961 ? 239 PHE   A CB  1 
ATOM   244  C CG  . PHE   A 1 43  ? 5.30100   -2.04800  -43.97600 1.000 56.77091 ? 239 PHE   A CG  1 
ATOM   245  C CD1 . PHE   A 1 43  ? 6.60500   -2.49500  -43.85900 1.000 58.33308 ? 239 PHE   A CD1 1 
ATOM   246  C CD2 . PHE   A 1 43  ? 4.77600   -1.82700  -45.25100 1.000 61.04567 ? 239 PHE   A CD2 1 
ATOM   247  C CE1 . PHE   A 1 43  ? 7.38400   -2.71900  -44.99500 1.000 57.60602 ? 239 PHE   A CE1 1 
ATOM   248  C CE2 . PHE   A 1 43  ? 5.54500   -2.05000  -46.39600 1.000 59.97392 ? 239 PHE   A CE2 1 
ATOM   249  C CZ  . PHE   A 1 43  ? 6.85000   -2.49300  -46.26800 1.000 59.57987 ? 239 PHE   A CZ  1 
ATOM   250  N N   . VAL   A 1 44  ? 3.42900   -4.98400  -43.65900 1.000 49.88627 ? 240 VAL   A N   1 
ATOM   251  C CA  . VAL   A 1 44  ? 3.73300   -6.41200  -43.67100 1.000 47.65357 ? 240 VAL   A CA  1 
ATOM   252  C C   . VAL   A 1 44  ? 5.17500   -6.63400  -44.12300 1.000 49.73578 ? 240 VAL   A C   1 
ATOM   253  O O   . VAL   A 1 44  ? 5.54400   -6.29800  -45.25500 1.000 53.43601 ? 240 VAL   A O   1 
ATOM   254  C CB  . VAL   A 1 44  ? 2.74600   -7.17200  -44.56900 1.000 50.12176 ? 240 VAL   A CB  1 
ATOM   255  C CG1 . VAL   A 1 44  ? 2.95400   -8.67100  -44.44100 1.000 50.91780 ? 240 VAL   A CG1 1 
ATOM   256  C CG2 . VAL   A 1 44  ? 1.31800   -6.80600  -44.19600 1.000 44.89787 ? 240 VAL   A CG2 1 
ATOM   257  N N   . ILE   A 1 45  ? 5.98100   -7.22500  -43.24800 1.000 45.72564 ? 241 ILE   A N   1 
ATOM   258  C CA  . ILE   A 1 45  ? 7.34500   -7.64600  -43.55300 1.000 48.04274 ? 241 ILE   A CA  1 
ATOM   259  C C   . ILE   A 1 45  ? 7.30800   -9.13100  -43.90700 1.000 51.01349 ? 241 ILE   A C   1 
ATOM   260  O O   . ILE   A 1 45  ? 7.02100   -9.97700  -43.05200 1.000 43.96643 ? 241 ILE   A O   1 
ATOM   261  C CB  . ILE   A 1 45  ? 8.28900   -7.38600  -42.37300 1.000 43.72037 ? 241 ILE   A CB  1 
ATOM   262  C CG1 . ILE   A 1 45  ? 8.38400   -5.88800  -42.07400 1.000 48.60112 ? 241 ILE   A CG1 1 
ATOM   263  C CG2 . ILE   A 1 45  ? 9.64900   -7.98000  -42.62800 1.000 44.64659 ? 241 ILE   A CG2 1 
ATOM   264  C CD1 . ILE   A 1 45  ? 8.90400   -5.59200  -40.68100 1.000 41.74973 ? 241 ILE   A CD1 1 
ATOM   265  N N   . HIS   A 1 46  ? 7.60300   -9.46800  -45.16700 1.000 50.79629 ? 242 HIS   A N   1 
ATOM   266  C CA  . HIS   A 1 46  ? 7.54600   -10.86200 -45.59900 1.000 51.97465 ? 242 HIS   A CA  1 
ATOM   267  C C   . HIS   A 1 46  ? 8.72900   -11.29200 -46.45200 1.000 55.29311 ? 242 HIS   A C   1 
ATOM   268  O O   . HIS   A 1 46  ? 8.76600   -12.45200 -46.86800 1.000 54.29896 ? 242 HIS   A O   1 
ATOM   269  C CB  . HIS   A 1 46  ? 6.25200   -11.13100 -46.38300 1.000 53.23594 ? 242 HIS   A CB  1 
ATOM   270  C CG  . HIS   A 1 46  ? 6.12600   -10.31800 -47.63700 1.000 57.32623 ? 242 HIS   A CG  1 
ATOM   271  N ND1 . HIS   A 1 46  ? 6.71000   -10.69300 -48.82900 1.000 61.66129 ? 242 HIS   A ND1 1 
ATOM   272  C CD2 . HIS   A 1 46  ? 5.48500   -9.15000  -47.88300 1.000 57.62504 ? 242 HIS   A CD2 1 
ATOM   273  C CE1 . HIS   A 1 46  ? 6.43500   -9.79100  -49.75500 1.000 60.38372 ? 242 HIS   A CE1 1 
ATOM   274  N NE2 . HIS   A 1 46  ? 5.69300   -8.84300  -49.20600 1.000 62.52016 ? 242 HIS   A NE2 1 
ATOM   275  N N   . ASP   A 1 47  ? 9.67200   -10.39900 -46.75300 1.000 57.61517 ? 243 ASP   A N   1 
ATOM   276  C CA  . ASP   A 1 47  ? 10.91400  -10.76400 -47.42200 1.000 55.85790 ? 243 ASP   A CA  1 
ATOM   277  C C   . ASP   A 1 47  ? 11.97500  -9.73500  -47.06200 1.000 58.51590 ? 243 ASP   A C   1 
ATOM   278  O O   . ASP   A 1 47  ? 11.73100  -8.79700  -46.29600 1.000 53.81164 ? 243 ASP   A O   1 
ATOM   279  C CB  . ASP   A 1 47  ? 10.73500  -10.86900 -48.94900 1.000 56.89610 ? 243 ASP   A CB  1 
ATOM   280  C CG  . ASP   A 1 47  ? 10.01400  -9.65900  -49.55200 1.000 58.70275 ? 243 ASP   A CG  1 
ATOM   281  O OD1 . ASP   A 1 47  ? 9.96300   -8.58600  -48.90700 1.000 52.86868 ? 243 ASP   A OD1 1 
ATOM   282  O OD2 . ASP   A 1 47  ? 9.49300   -9.78100  -50.68500 1.000 64.14895 ? 243 ASP   A OD2 1 
ATOM   283  N N   . MET   A 1 48  ? 13.16400  -9.91700  -47.63800 1.000 57.08419 ? 244 MET   A N   1 
ATOM   284  C CA  . MET   A 1 48  ? 14.23700  -8.94800  -47.46300 1.000 57.75150 ? 244 MET   A CA  1 
ATOM   285  C C   . MET   A 1 48  ? 13.79800  -7.55100  -47.87100 1.000 59.39953 ? 244 MET   A C   1 
ATOM   286  O O   . MET   A 1 48  ? 14.09900  -6.57000  -47.17900 1.000 57.17575 ? 244 MET   A O   1 
ATOM   287  C CB  . MET   A 1 48  ? 15.45100  -9.37200  -48.28500 1.000 61.53322 ? 244 MET   A CB  1 
ATOM   288  C CG  . MET   A 1 48  ? 16.51100  -10.11700 -47.51500 1.000 67.41205 ? 244 MET   A CG  1 
ATOM   289  S SD  . MET   A 1 48  ? 17.15100  -9.20600  -46.10400 1.000 78.24745 ? 244 MET   A SD  1 
ATOM   290  C CE  . MET   A 1 48  ? 17.24800  -7.53200  -46.72000 1.000 62.43373 ? 244 MET   A CE  1 
ATOM   291  N N   . GLU   A 1 49  ? 13.10600  -7.43700  -49.00300 1.000 56.51603 ? 245 GLU   A N   1 
ATOM   292  C CA  . GLU   A 1 49  ? 12.75400  -6.12200  -49.52700 1.000 61.98374 ? 245 GLU   A CA  1 
ATOM   293  C C   . GLU   A 1 49  ? 11.84800  -5.36600  -48.55800 1.000 56.70612 ? 245 GLU   A C   1 
ATOM   294  O O   . GLU   A 1 49  ? 12.14900  -4.23400  -48.16600 1.000 56.13062 ? 245 GLU   A O   1 
ATOM   295  C CB  . GLU   A 1 49  ? 12.09000  -6.27100  -50.90000 1.000 60.44416 ? 245 GLU   A CB  1 
ATOM   296  C CG  . GLU   A 1 49  ? 11.20000  -5.09400  -51.29900 1.000 68.99595 ? 245 GLU   A CG  1 
ATOM   297  C CD  . GLU   A 1 49  ? 11.96900  -3.97500  -51.97400 1.000 74.35482 ? 245 GLU   A CD  1 
ATOM   298  O OE1 . GLU   A 1 49  ? 11.45700  -2.83000  -51.99400 1.000 77.00150 ? 245 GLU   A OE1 1 
ATOM   299  O OE2 . GLU   A 1 49  ? 13.08200  -4.23800  -52.48300 1.000 79.74334 ? 245 GLU   A OE2 1 
ATOM   300  N N   . THR   A 1 50  ? 10.72400  -5.97700  -48.16800 1.000 50.42428 ? 246 THR   A N   1 
ATOM   301  C CA  . THR   A 1 50  ? 9.81000   -5.28900  -47.26300 1.000 53.11289 ? 246 THR   A CA  1 
ATOM   302  C C   . THR   A 1 50  ? 10.45300  -5.04000  -45.90200 1.000 50.87900 ? 246 THR   A C   1 
ATOM   303  O O   . THR   A 1 50  ? 10.16500  -4.02500  -45.26100 1.000 52.70544 ? 246 THR   A O   1 
ATOM   304  C CB  . THR   A 1 50  ? 8.50600   -6.07500  -47.11200 1.000 49.70045 ? 246 THR   A CB  1 
ATOM   305  O OG1 . THR   A 1 50  ? 8.79000   -7.46200  -46.93200 1.000 48.50248 ? 246 THR   A OG1 1 
ATOM   306  C CG2 . THR   A 1 50  ? 7.64300   -5.90500  -48.34500 1.000 50.82555 ? 246 THR   A CG2 1 
ATOM   307  N N   . LEU   A 1 51  ? 11.33900  -5.93200  -45.45000 1.000 51.28661 ? 247 LEU   A N   1 
ATOM   308  C CA  . LEU   A 1 51  ? 12.07600  -5.64900  -44.22600 1.000 50.70260 ? 247 LEU   A CA  1 
ATOM   309  C C   . LEU   A 1 51  ? 12.87400  -4.36100  -44.36400 1.000 53.91592 ? 247 LEU   A C   1 
ATOM   310  O O   . LEU   A 1 51  ? 12.90000  -3.53300  -43.44000 1.000 44.84502 ? 247 LEU   A O   1 
ATOM   311  C CB  . LEU   A 1 51  ? 12.99400  -6.82200  -43.86400 1.000 46.11113 ? 247 LEU   A CB  1 
ATOM   312  C CG  . LEU   A 1 51  ? 14.04400  -6.55700  -42.77300 1.000 49.58506 ? 247 LEU   A CG  1 
ATOM   313  C CD1 . LEU   A 1 51  ? 13.39200  -6.19200  -41.42200 1.000 50.19790 ? 247 LEU   A CD1 1 
ATOM   314  C CD2 . LEU   A 1 51  ? 14.99200  -7.73700  -42.59000 1.000 50.19499 ? 247 LEU   A CD2 1 
ATOM   315  N N   . CYS   A 1 52  ? 13.51100  -4.15900  -45.52600 1.000 52.98028 ? 248 CYS   A N   1 
ATOM   316  C CA  . CYS   A 1 52  ? 14.29500  -2.94500  -45.73700 1.000 51.75274 ? 248 CYS   A CA  1 
ATOM   317  C C   . CYS   A 1 52  ? 13.41000  -1.70600  -45.75100 1.000 49.30125 ? 248 CYS   A C   1 
ATOM   318  O O   . CYS   A 1 52  ? 13.77800  -0.67000  -45.18600 1.000 52.36165 ? 248 CYS   A O   1 
ATOM   319  C CB  . CYS   A 1 52  ? 15.09100  -3.05300  -47.04000 1.000 56.67666 ? 248 CYS   A CB  1 
ATOM   320  S SG  . CYS   A 1 52  ? 16.54600  -4.11300  -46.92400 1.000 60.18108 ? 248 CYS   A SG  1 
ATOM   321  N N   . MET   A 1 53  ? 12.24300  -1.79100  -46.40400 1.000 49.03568 ? 249 MET   A N   1 
ATOM   322  C CA  . MET   A 1 53  ? 11.30100  -0.67400  -46.41500 1.000 52.70113 ? 249 MET   A CA  1 
ATOM   323  C C   . MET   A 1 53  ? 10.83900  -0.31700  -45.00800 1.000 50.10718 ? 249 MET   A C   1 
ATOM   324  O O   . MET   A 1 53  ? 10.74200  0.86400   -44.66200 1.000 50.52549 ? 249 MET   A O   1 
ATOM   325  C CB  . MET   A 1 53  ? 10.08900  -1.00800  -47.28600 1.000 52.78117 ? 249 MET   A CB  1 
ATOM   326  C CG  . MET   A 1 53  ? 10.23700  -0.66800  -48.77000 1.000 66.14441 ? 249 MET   A CG  1 
ATOM   327  S SD  . MET   A 1 53  ? 10.02900  1.09300   -49.15800 1.000 86.04985 ? 249 MET   A SD  1 
ATOM   328  C CE  . MET   A 1 53  ? 9.02400   1.66900   -47.78300 1.000 66.73213 ? 249 MET   A CE  1 
ATOM   329  N N   . ALA   A 1 54  ? 10.51500  -1.32700  -44.19200 1.000 51.47346 ? 250 ALA   A N   1 
ATOM   330  C CA  . ALA   A 1 54  ? 10.09000  -1.05900  -42.81900 1.000 51.27638 ? 250 ALA   A CA  1 
ATOM   331  C C   . ALA   A 1 54  ? 11.18500  -0.34700  -42.04100 1.000 48.94109 ? 250 ALA   A C   1 
ATOM   332  O O   . ALA   A 1 54  ? 10.93100  0.65900   -41.36700 1.000 46.00939 ? 250 ALA   A O   1 
ATOM   333  C CB  . ALA   A 1 54  ? 9.69700   -2.36100  -42.12600 1.000 47.22544 ? 250 ALA   A CB  1 
ATOM   334  N N   . GLU   A 1 55  ? 12.41800  -0.84100  -42.14900 1.000 45.09123 ? 251 GLU   A N   1 
ATOM   335  C CA  . GLU   A 1 55  ? 13.53500  -0.20600  -41.46700 1.000 49.69411 ? 251 GLU   A CA  1 
ATOM   336  C C   . GLU   A 1 55  ? 13.71300  1.24600   -41.89800 1.000 55.37018 ? 251 GLU   A C   1 
ATOM   337  O O   . GLU   A 1 55  ? 13.92100  2.13200   -41.05800 1.000 52.86608 ? 251 GLU   A O   1 
ATOM   338  C CB  . GLU   A 1 55  ? 14.80500  -1.00400  -41.73400 1.000 52.33301 ? 251 GLU   A CB  1 
ATOM   339  C CG  . GLU   A 1 55  ? 14.78200  -2.39700  -41.11000 1.000 52.86646 ? 251 GLU   A CG  1 
ATOM   340  C CD  . GLU   A 1 55  ? 15.94000  -3.24800  -41.57200 1.000 55.74345 ? 251 GLU   A CD  1 
ATOM   341  O OE1 . GLU   A 1 55  ? 16.58800  -3.86300  -40.70300 1.000 50.08876 ? 251 GLU   A OE1 1 
ATOM   342  O OE2 . GLU   A 1 55  ? 16.21000  -3.28600  -42.79900 1.000 55.58620 ? 251 GLU   A OE2 1 
ATOM   343  N N   . LYS   A 1 56  ? 13.64600  1.50300   -43.20500 1.000 50.69762 ? 252 LYS   A N   1 
ATOM   344  C CA  . LYS   A 1 56  ? 13.88400  2.85100   -43.71300 1.000 59.41826 ? 252 LYS   A CA  1 
ATOM   345  C C   . LYS   A 1 56  ? 12.88600  3.84900   -43.13700 1.000 54.17782 ? 252 LYS   A C   1 
ATOM   346  O O   . LYS   A 1 56  ? 13.23400  5.00200   -42.87500 1.000 58.30198 ? 252 LYS   A O   1 
ATOM   347  C CB  . LYS   A 1 56  ? 13.81500  2.84900   -45.24400 1.000 54.31950 ? 252 LYS   A CB  1 
ATOM   348  C CG  . LYS   A 1 56  ? 13.89000  4.22800   -45.86800 1.000 59.07731 ? 252 LYS   A CG  1 
ATOM   349  C CD  . LYS   A 1 56  ? 13.48700  4.22200   -47.33700 1.000 60.83457 ? 252 LYS   A CD  1 
ATOM   350  C CE  . LYS   A 1 56  ? 13.77100  2.87900   -47.99900 1.000 61.26849 ? 252 LYS   A CE  1 
ATOM   351  N NZ  . LYS   A 1 56  ? 13.39600  2.91700   -49.45100 1.000 65.00266 ? 252 LYS   A NZ  1 
ATOM   352  N N   . THR   A 1 57  ? 11.64000  3.43300   -42.94700 1.000 50.68495 ? 253 THR   A N   1 
ATOM   353  C CA  . THR   A 1 57  ? 10.64900  4.37900   -42.46300 1.000 56.70583 ? 253 THR   A CA  1 
ATOM   354  C C   . THR   A 1 57  ? 10.54700  4.37400   -40.94100 1.000 57.87346 ? 253 THR   A C   1 
ATOM   355  O O   . THR   A 1 57  ? 10.42200  5.44100   -40.33600 1.000 57.26399 ? 253 THR   A O   1 
ATOM   356  C CB  . THR   A 1 57  ? 9.28300   4.09400   -43.09500 1.000 58.35670 ? 253 THR   A CB  1 
ATOM   357  O OG1 . THR   A 1 57  ? 8.73400   2.89800   -42.53800 1.000 65.00832 ? 253 THR   A OG1 1 
ATOM   358  C CG2 . THR   A 1 57  ? 9.41400   3.91300   -44.60500 1.000 61.10882 ? 253 THR   A CG2 1 
ATOM   359  N N   . LEU   A 1 58  ? 10.64900  3.20800   -40.29400 1.000 52.34680 ? 254 LEU   A N   1 
ATOM   360  C CA  . LEU   A 1 58  ? 10.45500  3.14500   -38.84800 1.000 51.75179 ? 254 LEU   A CA  1 
ATOM   361  C C   . LEU   A 1 58  ? 11.72100  3.41000   -38.03800 1.000 53.86435 ? 254 LEU   A C   1 
ATOM   362  O O   . LEU   A 1 58  ? 11.62700  3.97000   -36.93800 1.000 55.80634 ? 254 LEU   A O   1 
ATOM   363  C CB  . LEU   A 1 58  ? 9.87800   1.78600   -38.45100 1.000 47.50073 ? 254 LEU   A CB  1 
ATOM   364  C CG  . LEU   A 1 58  ? 8.44100   1.53600   -38.89600 1.000 48.37664 ? 254 LEU   A CG  1 
ATOM   365  C CD1 . LEU   A 1 58  ? 7.95000   0.22700   -38.33700 1.000 48.90046 ? 254 LEU   A CD1 1 
ATOM   366  C CD2 . LEU   A 1 58  ? 7.52600   2.68600   -38.47500 1.000 51.97044 ? 254 LEU   A CD2 1 
ATOM   367  N N   . VAL   A 1 59  ? 12.89800  3.00000   -38.51800 1.000 53.45821 ? 255 VAL   A N   1 
ATOM   368  C CA  . VAL   A 1 59  ? 14.14600  3.33300   -37.83000 1.000 55.24156 ? 255 VAL   A CA  1 
ATOM   369  C C   . VAL   A 1 59  ? 15.14600  3.92800   -38.81600 1.000 61.87002 ? 255 VAL   A C   1 
ATOM   370  O O   . VAL   A 1 59  ? 16.16800  3.30800   -39.13700 1.000 57.99822 ? 255 VAL   A O   1 
ATOM   371  C CB  . VAL   A 1 59  ? 14.75100  2.11700   -37.10600 1.000 56.12798 ? 255 VAL   A CB  1 
ATOM   372  C CG1 . VAL   A 1 59  ? 14.05700  1.89900   -35.77700 1.000 55.83291 ? 255 VAL   A CG1 1 
ATOM   373  C CG2 . VAL   A 1 59  ? 14.66900  0.87200   -37.97000 1.000 54.72166 ? 255 VAL   A CG2 1 
ATOM   374  N N   . ALA   A 1 60  ? 14.86900  5.15100   -39.27700 1.000 61.22461 ? 256 ALA   A N   1 
ATOM   375  C CA  . ALA   A 1 60  ? 15.71100  5.76700   -40.29500 1.000 64.17704 ? 256 ALA   A CA  1 
ATOM   376  C C   . ALA   A 1 60  ? 17.14300  5.97400   -39.81000 1.000 66.71644 ? 256 ALA   A C   1 
ATOM   377  O O   . ALA   A 1 60  ? 18.08300  5.86700   -40.60400 1.000 66.80004 ? 256 ALA   A O   1 
ATOM   378  C CB  . ALA   A 1 60  ? 15.10000  7.09400   -40.74600 1.000 63.74172 ? 256 ALA   A CB  1 
ATOM   379  N N   . LYS   A 1 61  ? 17.33900  6.26500   -38.51900 1.000 66.56816 ? 257 LYS   A N   1 
ATOM   380  C CA  . LYS   A 1 61  ? 18.69900  6.50300   -38.03800 1.000 68.29313 ? 257 LYS   A CA  1 
ATOM   381  C C   . LYS   A 1 61  ? 19.57700  5.26200   -38.17800 1.000 73.06714 ? 257 LYS   A C   1 
ATOM   382  O O   . LYS   A 1 61  ? 20.78600  5.38000   -38.41500 1.000 73.47490 ? 257 LYS   A O   1 
ATOM   383  C CB  . LYS   A 1 61  ? 18.68100  6.97200   -36.58300 1.000 71.12363 ? 257 LYS   A CB  1 
ATOM   384  C CG  . LYS   A 1 61  ? 20.06800  7.25400   -36.03100 1.000 74.20824 ? 257 LYS   A CG  1 
ATOM   385  C CD  . LYS   A 1 61  ? 20.02900  7.79300   -34.61300 1.000 80.12373 ? 257 LYS   A CD  1 
ATOM   386  C CE  . LYS   A 1 61  ? 21.44300  7.98000   -34.07400 1.000 82.81272 ? 257 LYS   A CE  1 
ATOM   387  N NZ  . LYS   A 1 61  ? 21.46600  8.54900   -32.69700 1.000 79.83262 ? 257 LYS   A NZ  1 
ATOM   388  N N   . LEU   A 1 62  ? 18.99100  4.07000   -38.05200 1.000 69.43085 ? 258 LEU   A N   1 
ATOM   389  C CA  . LEU   A 1 62  ? 19.77700  2.84400   -38.11400 1.000 69.25689 ? 258 LEU   A CA  1 
ATOM   390  C C   . LEU   A 1 62  ? 20.17300  2.50300   -39.54500 1.000 71.77639 ? 258 LEU   A C   1 
ATOM   391  O O   . LEU   A 1 62  ? 21.28100  2.00400   -39.78000 1.000 71.92532 ? 258 LEU   A O   1 
ATOM   392  C CB  . LEU   A 1 62  ? 18.99300  1.68400   -37.49900 1.000 66.79096 ? 258 LEU   A CB  1 
ATOM   393  C CG  . LEU   A 1 62  ? 19.07400  1.42300   -35.99000 1.000 69.65979 ? 258 LEU   A CG  1 
ATOM   394  C CD1 . LEU   A 1 62  ? 18.75800  2.67400   -35.18400 1.000 68.43618 ? 258 LEU   A CD1 1 
ATOM   395  C CD2 . LEU   A 1 62  ? 18.13600  0.28700   -35.60000 1.000 63.66405 ? 258 LEU   A CD2 1 
ATOM   396  N N   . VAL   A 1 63  ? 19.27500  2.74000   -40.50900 1.000 68.52892 ? 259 VAL   A N   1 
ATOM   397  C CA  . VAL   A 1 63  ? 19.58700  2.40100   -41.89600 1.000 72.29509 ? 259 VAL   A CA  1 
ATOM   398  C C   . VAL   A 1 63  ? 20.74800  3.24900   -42.39800 1.000 75.94390 ? 259 VAL   A C   1 
ATOM   399  O O   . VAL   A 1 63  ? 21.59700  2.76400   -43.16000 1.000 75.83792 ? 259 VAL   A O   1 
ATOM   400  C CB  . VAL   A 1 63  ? 18.33000  2.53200   -42.79300 1.000 71.16551 ? 259 VAL   A CB  1 
ATOM   401  C CG1 . VAL   A 1 63  ? 17.90900  3.98200   -42.98200 1.000 70.31527 ? 259 VAL   A CG1 1 
ATOM   402  C CG2 . VAL   A 1 63  ? 18.57000  1.89500   -44.15100 1.000 73.08254 ? 259 VAL   A CG2 1 
ATOM   403  N N   . ALA   A 1 64  ? 20.83200  4.50600   -41.94900 1.000 75.74974 ? 260 ALA   A N   1 
ATOM   404  C CA  . ALA   A 1 64  ? 21.90900  5.41100   -42.32200 1.000 79.07702 ? 260 ALA   A CA  1 
ATOM   405  C C   . ALA   A 1 64  ? 23.16200  5.21300   -41.47600 1.000 80.29699 ? 260 ALA   A C   1 
ATOM   406  O O   . ALA   A 1 64  ? 24.10400  6.00300   -41.59800 1.000 83.39484 ? 260 ALA   A O   1 
ATOM   407  C CB  . ALA   A 1 64  ? 21.43500  6.86400   -42.22700 1.000 72.60405 ? 260 ALA   A CB  1 
ATOM   408  N N   . ASN   A 1 65  ? 23.19000  4.18100   -40.62900 1.000 79.63717 ? 261 ASN   A N   1 
ATOM   409  C CA  . ASN   A 1 65  ? 24.36700  3.83800   -39.83700 1.000 81.51824 ? 261 ASN   A CA  1 
ATOM   410  C C   . ASN   A 1 65  ? 24.90700  2.45600   -40.19400 1.000 78.31706 ? 261 ASN   A C   1 
ATOM   411  O O   . ASN   A 1 65  ? 25.69100  1.88100   -39.43400 1.000 82.98361 ? 261 ASN   A O   1 
ATOM   412  C CB  . ASN   A 1 65  ? 24.05200  3.91800   -38.34100 1.000 77.49156 ? 261 ASN   A CB  1 
ATOM   413  C CG  . ASN   A 1 65  ? 24.28900  5.30200   -37.77300 1.000 80.73302 ? 261 ASN   A CG  1 
ATOM   414  O OD1 . ASN   A 1 65  ? 25.29900  5.94500   -38.06900 1.000 86.06157 ? 261 ASN   A OD1 1 
ATOM   415  N ND2 . ASN   A 1 65  ? 23.35200  5.77600   -36.96500 1.000 79.69856 ? 261 ASN   A ND2 1 
ATOM   416  N N   . GLY   A 1 66  ? 24.49300  1.91000   -41.33200 1.000 76.16960 ? 262 GLY   A N   1 
ATOM   417  C CA  . GLY   A 1 66  ? 25.05100  0.66200   -41.80600 1.000 75.94883 ? 262 GLY   A CA  1 
ATOM   418  C C   . GLY   A 1 66  ? 24.40400  -0.59200  -41.26900 1.000 75.47227 ? 262 GLY   A C   1 
ATOM   419  O O   . GLY   A 1 66  ? 25.00100  -1.66800  -41.37400 1.000 74.29899 ? 262 GLY   A O   1 
ATOM   420  N N   . ILE   A 1 67  ? 23.19700  -0.49800  -40.69800 1.000 74.70001 ? 263 ILE   A N   1 
ATOM   421  C CA  . ILE   A 1 67  ? 22.56900  -1.69800  -40.14900 1.000 71.29917 ? 263 ILE   A CA  1 
ATOM   422  C C   . ILE   A 1 67  ? 22.12100  -2.62500  -41.26700 1.000 71.04713 ? 263 ILE   A C   1 
ATOM   423  O O   . ILE   A 1 67  ? 22.02900  -3.84500  -41.07100 1.000 66.56976 ? 263 ILE   A O   1 
ATOM   424  C CB  . ILE   A 1 67  ? 21.39700  -1.34300  -39.21400 1.000 73.56898 ? 263 ILE   A CB  1 
ATOM   425  C CG1 . ILE   A 1 67  ? 21.09000  -2.53000  -38.29700 1.000 72.39896 ? 263 ILE   A CG1 1 
ATOM   426  C CG2 . ILE   A 1 67  ? 20.15000  -0.98400  -40.01200 1.000 61.97753 ? 263 ILE   A CG2 1 
ATOM   427  C CD1 . ILE   A 1 67  ? 20.88300  -2.15600  -36.84600 1.000 75.79877 ? 263 ILE   A CD1 1 
ATOM   428  N N   . GLN   A 1 68  ? 21.85300  -2.08200  -42.45600 1.000 69.56788 ? 264 GLN   A N   1 
ATOM   429  C CA  . GLN   A 1 68  ? 21.47500  -2.92300  -43.58000 1.000 69.90612 ? 264 GLN   A CA  1 
ATOM   430  C C   . GLN   A 1 68  ? 22.66500  -3.65200  -44.19400 1.000 70.45145 ? 264 GLN   A C   1 
ATOM   431  O O   . GLN   A 1 68  ? 22.47500  -4.43800  -45.13000 1.000 70.96091 ? 264 GLN   A O   1 
ATOM   432  C CB  . GLN   A 1 68  ? 20.75100  -2.09100  -44.63400 1.000 69.29015 ? 264 GLN   A CB  1 
ATOM   433  C CG  . GLN   A 1 68  ? 19.29400  -2.48000  -44.78100 1.000 71.18811 ? 264 GLN   A CG  1 
ATOM   434  C CD  . GLN   A 1 68  ? 18.43800  -1.35700  -45.33200 1.000 71.69136 ? 264 GLN   A CD  1 
ATOM   435  O OE1 . GLN   A 1 68  ? 18.89400  -0.55700  -46.15200 1.000 74.19628 ? 264 GLN   A OE1 1 
ATOM   436  N NE2 . GLN   A 1 68  ? 17.19200  -1.28000  -44.87000 1.000 65.99669 ? 264 GLN   A NE2 1 
ATOM   437  N N   . ASN   A 1 69  ? 23.87500  -3.41400  -43.68300 1.000 67.42031 ? 265 ASN   A N   1 
ATOM   438  C CA  . ASN   A 1 69  ? 25.01700  -4.24700  -44.04200 1.000 74.46913 ? 265 ASN   A CA  1 
ATOM   439  C C   . ASN   A 1 69  ? 24.91700  -5.61900  -43.38200 1.000 75.60506 ? 265 ASN   A C   1 
ATOM   440  O O   . ASN   A 1 69  ? 25.06100  -6.65000  -44.05100 1.000 76.24952 ? 265 ASN   A O   1 
ATOM   441  C CB  . ASN   A 1 69  ? 26.32200  -3.55600  -43.64200 1.000 72.34380 ? 265 ASN   A CB  1 
ATOM   442  C CG  . ASN   A 1 69  ? 26.50500  -2.22100  -44.33000 1.000 78.07918 ? 265 ASN   A CG  1 
ATOM   443  O OD1 . ASN   A 1 69  ? 26.06100  -2.02800  -45.46700 1.000 78.54721 ? 265 ASN   A OD1 1 
ATOM   444  N ND2 . ASN   A 1 69  ? 27.14400  -1.28100  -43.63800 1.000 75.22587 ? 265 ASN   A ND2 1 
ATOM   445  N N   . LYS   A 1 70  ? 24.66600  -5.65100  -42.07000 1.000 72.08162 ? 266 LYS   A N   1 
ATOM   446  C CA  . LYS   A 1 70  ? 24.58100  -6.92300  -41.37400 1.000 69.60476 ? 266 LYS   A CA  1 
ATOM   447  C C   . LYS   A 1 70  ? 23.35000  -7.69700  -41.83900 1.000 63.56323 ? 266 LYS   A C   1 
ATOM   448  O O   . LYS   A 1 70  ? 22.44500  -7.16100  -42.48400 1.000 65.32165 ? 266 LYS   A O   1 
ATOM   449  C CB  . LYS   A 1 70  ? 24.56600  -6.72000  -39.85900 1.000 68.17983 ? 266 LYS   A CB  1 
ATOM   450  C CG  . LYS   A 1 70  ? 23.99700  -5.39600  -39.39700 1.000 72.86796 ? 266 LYS   A CG  1 
ATOM   451  C CD  . LYS   A 1 70  ? 23.98800  -5.29500  -37.87700 1.000 72.71800 ? 266 LYS   A CD  1 
ATOM   452  C CE  . LYS   A 1 70  ? 25.37300  -4.98700  -37.33300 1.000 77.85080 ? 266 LYS   A CE  1 
ATOM   453  N NZ  . LYS   A 1 70  ? 25.97400  -3.81000  -38.03200 1.000 83.20448 ? 266 LYS   A NZ  1 
ATOM   454  N N   . GLU   A 1 71  ? 23.34000  -8.98600  -41.51400 1.000 63.14297 ? 267 GLU   A N   1 
ATOM   455  C CA  . GLU   A 1 71  ? 22.35000  -9.91200  -42.04500 1.000 59.98095 ? 267 GLU   A CA  1 
ATOM   456  C C   . GLU   A 1 71  ? 20.94000  -9.54800  -41.58200 1.000 59.62422 ? 267 GLU   A C   1 
ATOM   457  O O   . GLU   A 1 71  ? 20.73800  -8.90200  -40.54800 1.000 58.15092 ? 267 GLU   A O   1 
ATOM   458  C CB  . GLU   A 1 71  ? 22.66700  -11.33700 -41.59400 1.000 61.25335 ? 267 GLU   A CB  1 
ATOM   459  C CG  . GLU   A 1 71  ? 23.97800  -11.90500 -42.09700 1.000 60.84040 ? 267 GLU   A CG  1 
ATOM   460  C CD  . GLU   A 1 71  ? 24.05800  -13.40700 -41.88100 1.000 62.09059 ? 267 GLU   A CD  1 
ATOM   461  O OE1 . GLU   A 1 71  ? 24.75200  -13.83800 -40.93400 1.000 67.45969 ? 267 GLU   A OE1 1 
ATOM   462  O OE2 . GLU   A 1 71  ? 23.40600  -14.15400 -42.64500 1.000 59.98668 ? 267 GLU   A OE2 1 
ATOM   463  N N   . ALA   A 1 72  ? 19.95500  -9.99800  -42.36200 1.000 55.86569 ? 268 ALA   A N   1 
ATOM   464  C CA  . ALA   A 1 72  ? 18.56100  -9.85300  -41.95800 1.000 58.34902 ? 268 ALA   A CA  1 
ATOM   465  C C   . ALA   A 1 72  ? 18.30900  -10.52300 -40.61100 1.000 55.01299 ? 268 ALA   A C   1 
ATOM   466  O O   . ALA   A 1 72  ? 17.65100  -9.94800  -39.73600 1.000 52.63851 ? 268 ALA   A O   1 
ATOM   467  C CB  . ALA   A 1 72  ? 17.64000  -10.44400 -43.02500 1.000 54.13330 ? 268 ALA   A CB  1 
ATOM   468  N N   . GLU   A 1 73  ? 18.83700  -11.73500 -40.43000 1.000 53.69912 ? 269 GLU   A N   1 
ATOM   469  C CA  . GLU   A 1 73  ? 18.70000  -12.44200 -39.16200 1.000 52.02788 ? 269 GLU   A CA  1 
ATOM   470  C C   . GLU   A 1 73  ? 19.24800  -11.62200 -38.00200 1.000 56.02498 ? 269 GLU   A C   1 
ATOM   471  O O   . GLU   A 1 73  ? 18.66600  -11.61600 -36.91100 1.000 53.68431 ? 269 GLU   A O   1 
ATOM   472  C CB  . GLU   A 1 73  ? 19.41600  -13.78900 -39.23100 1.000 50.45563 ? 269 GLU   A CB  1 
ATOM   473  C CG  . GLU   A 1 73  ? 18.72600  -14.83700 -40.10500 1.000 55.29938 ? 269 GLU   A CG  1 
ATOM   474  C CD  . GLU   A 1 73  ? 19.10500  -14.71900 -41.57600 1.000 55.47384 ? 269 GLU   A CD  1 
ATOM   475  O OE1 . GLU   A 1 73  ? 19.85300  -13.78600 -41.93400 1.000 50.51319 ? 269 GLU   A OE1 1 
ATOM   476  O OE2 . GLU   A 1 73  ? 18.65000  -15.56500 -42.37400 1.000 57.43359 ? 269 GLU   A OE2 1 
ATOM   477  N N   . VAL   A 1 74  ? 20.37500  -10.93700 -38.20700 1.000 53.91943 ? 270 VAL   A N   1 
ATOM   478  C CA  . VAL   A 1 74  ? 20.95400  -10.17700 -37.10300 1.000 52.72847 ? 270 VAL   A CA  1 
ATOM   479  C C   . VAL   A 1 74  ? 20.13400  -8.92700  -36.81700 1.000 53.32805 ? 270 VAL   A C   1 
ATOM   480  O O   . VAL   A 1 74  ? 20.02700  -8.48800  -35.66300 1.000 52.64166 ? 270 VAL   A O   1 
ATOM   481  C CB  . VAL   A 1 74  ? 22.42400  -9.84200  -37.40100 1.000 57.39839 ? 270 VAL   A CB  1 
ATOM   482  C CG1 . VAL   A 1 74  ? 23.00500  -8.98000  -36.29700 1.000 57.18705 ? 270 VAL   A CG1 1 
ATOM   483  C CG2 . VAL   A 1 74  ? 23.22700  -11.13700 -37.54800 1.000 57.67221 ? 270 VAL   A CG2 1 
ATOM   484  N N   . ARG   A 1 75  ? 19.53100  -8.34000  -37.84300 1.000 52.61115 ? 271 ARG   A N   1 
ATOM   485  C CA  . ARG   A 1 75  ? 18.68200  -7.18200  -37.60600 1.000 54.64097 ? 271 ARG   A CA  1 
ATOM   486  C C   . ARG   A 1 75  ? 17.40800  -7.58000  -36.86800 1.000 48.35489 ? 271 ARG   A C   1 
ATOM   487  O O   . ARG   A 1 75  ? 16.99100  -6.89500  -35.92900 1.000 51.63226 ? 271 ARG   A O   1 
ATOM   488  C CB  . ARG   A 1 75  ? 18.35700  -6.50400  -38.93100 1.000 53.16737 ? 271 ARG   A CB  1 
ATOM   489  C CG  . ARG   A 1 75  ? 19.49200  -5.65700  -39.47100 1.000 60.63440 ? 271 ARG   A CG  1 
ATOM   490  C CD  . ARG   A 1 75  ? 19.73700  -5.97200  -40.94000 1.000 60.76939 ? 271 ARG   A CD  1 
ATOM   491  N NE  . ARG   A 1 75  ? 18.70600  -5.40200  -41.79600 1.000 51.98014 ? 271 ARG   A NE  1 
ATOM   492  C CZ  . ARG   A 1 75  ? 18.55300  -5.69700  -43.08000 1.000 61.11216 ? 271 ARG   A CZ  1 
ATOM   493  N NH1 . ARG   A 1 75  ? 19.35100  -6.56100  -43.69200 1.000 55.47602 ? 271 ARG   A NH1 1 
ATOM   494  N NH2 . ARG   A 1 75  ? 17.58000  -5.10700  -43.77000 1.000 59.46951 ? 271 ARG   A NH2 1 
ATOM   495  N N   . ILE   A 1 76  ? 16.77500  -8.67800  -37.28300 1.000 50.09674 ? 272 ILE   A N   1 
ATOM   496  C CA  . ILE   A 1 76  ? 15.59100  -9.14800  -36.58400 1.000 52.24089 ? 272 ILE   A CA  1 
ATOM   497  C C   . ILE   A 1 76  ? 15.94700  -9.54600  -35.16000 1.000 52.33386 ? 272 ILE   A C   1 
ATOM   498  O O   . ILE   A 1 76  ? 15.19500  -9.26500  -34.21500 1.000 48.61882 ? 272 ILE   A O   1 
ATOM   499  C CB  . ILE   A 1 76  ? 14.94600  -10.31100 -37.35100 1.000 52.21077 ? 272 ILE   A CB  1 
ATOM   500  C CG1 . ILE   A 1 76  ? 14.57900  -9.87100  -38.77100 1.000 47.26996 ? 272 ILE   A CG1 1 
ATOM   501  C CG2 . ILE   A 1 76  ? 13.71200  -10.82500 -36.60200 1.000 48.39882 ? 272 ILE   A CG2 1 
ATOM   502  C CD1 . ILE   A 1 76  ? 14.24300  -11.04200 -39.68200 1.000 49.94241 ? 272 ILE   A CD1 1 
ATOM   503  N N   . PHE   A 1 77  ? 17.10900  -10.18800 -34.98800 1.000 49.73905 ? 273 PHE   A N   1 
ATOM   504  C CA  . PHE   A 1 77  ? 17.60400  -10.53800 -33.66200 1.000 49.39427 ? 273 PHE   A CA  1 
ATOM   505  C C   . PHE   A 1 77  ? 17.63800  -9.32200  -32.75200 1.000 49.82252 ? 273 PHE   A C   1 
ATOM   506  O O   . PHE   A 1 77  ? 17.21800  -9.38600  -31.59100 1.000 48.94771 ? 273 PHE   A O   1 
ATOM   507  C CB  . PHE   A 1 77  ? 18.99800  -11.16600 -33.77500 1.000 47.44794 ? 273 PHE   A CB  1 
ATOM   508  C CG  . PHE   A 1 77  ? 19.74600  -11.24800 -32.47300 1.000 51.78569 ? 273 PHE   A CG  1 
ATOM   509  C CD1 . PHE   A 1 77  ? 19.68400  -12.39300 -31.69800 1.000 54.36199 ? 273 PHE   A CD1 1 
ATOM   510  C CD2 . PHE   A 1 77  ? 20.53300  -10.19200 -32.03200 1.000 52.39454 ? 273 PHE   A CD2 1 
ATOM   511  C CE1 . PHE   A 1 77  ? 20.38000  -12.47400 -30.49400 1.000 53.31797 ? 273 PHE   A CE1 1 
ATOM   512  C CE2 . PHE   A 1 77  ? 21.22100  -10.27300 -30.84300 1.000 55.91311 ? 273 PHE   A CE2 1 
ATOM   513  C CZ  . PHE   A 1 77  ? 21.14100  -11.41700 -30.07200 1.000 55.18339 ? 273 PHE   A CZ  1 
ATOM   514  N N   . HIS   A 1 78  ? 18.14500  -8.19600  -33.25800 1.000 50.22498 ? 274 HIS   A N   1 
ATOM   515  C CA  . HIS   A 1 78  ? 18.24700  -7.02000  -32.40100 1.000 52.54621 ? 274 HIS   A CA  1 
ATOM   516  C C   . HIS   A 1 78  ? 16.87900  -6.40500  -32.13600 1.000 50.70309 ? 274 HIS   A C   1 
ATOM   517  O O   . HIS   A 1 78  ? 16.62100  -5.91500  -31.03300 1.000 44.72116 ? 274 HIS   A O   1 
ATOM   518  C CB  . HIS   A 1 78  ? 19.21600  -6.00300  -33.00100 1.000 53.35628 ? 274 HIS   A CB  1 
ATOM   519  C CG  . HIS   A 1 78  ? 20.64500  -6.33100  -32.70800 1.000 58.57582 ? 274 HIS   A CG  1 
ATOM   520  N ND1 . HIS   A 1 78  ? 21.24900  -6.00400  -31.51100 1.000 58.94007 ? 274 HIS   A ND1 1 
ATOM   521  C CD2 . HIS   A 1 78  ? 21.58000  -6.98900  -33.43400 1.000 61.21455 ? 274 HIS   A CD2 1 
ATOM   522  C CE1 . HIS   A 1 78  ? 22.49600  -6.43900  -31.51700 1.000 63.22608 ? 274 HIS   A CE1 1 
ATOM   523  N NE2 . HIS   A 1 78  ? 22.72300  -7.04200  -32.67100 1.000 63.54011 ? 274 HIS   A NE2 1 
ATOM   524  N N   . CYS   A 1 79  ? 15.98500  -6.43800  -33.12300 1.000 48.33134 ? 275 CYS   A N   1 
ATOM   525  C CA  . CYS   A 1 79  ? 14.60700  -6.02400  -32.88000 1.000 51.77824 ? 275 CYS   A CA  1 
ATOM   526  C C   . CYS   A 1 79  ? 13.99000  -6.81500  -31.72800 1.000 50.31513 ? 275 CYS   A C   1 
ATOM   527  O O   . CYS   A 1 79  ? 13.47600  -6.24000  -30.76100 1.000 44.82943 ? 275 CYS   A O   1 
ATOM   528  C CB  . CYS   A 1 79  ? 13.77500  -6.19600  -34.15000 1.000 50.18131 ? 275 CYS   A CB  1 
ATOM   529  S SG  . CYS   A 1 79  ? 11.96900  -6.19700  -33.85300 1.000 61.54478 ? 275 CYS   A SG  1 
ATOM   530  N N   . CYS   A 1 80  ? 14.02500  -8.14600  -31.82400 1.000 46.79043 ? 276 CYS   A N   1 
ATOM   531  C CA  . CYS   A 1 80  ? 13.44800  -8.97400  -30.77400 1.000 48.77146 ? 276 CYS   A CA  1 
ATOM   532  C C   . CYS   A 1 80  ? 14.12600  -8.72100  -29.43200 1.000 47.44023 ? 276 CYS   A C   1 
ATOM   533  O O   . CYS   A 1 80  ? 13.45300  -8.59000  -28.39700 1.000 43.47397 ? 276 CYS   A O   1 
ATOM   534  C CB  . CYS   A 1 80  ? 13.55200  -10.44200 -31.17100 1.000 42.98635 ? 276 CYS   A CB  1 
ATOM   535  S SG  . CYS   A 1 80  ? 12.53100  -10.83000 -32.60400 1.000 49.35752 ? 276 CYS   A SG  1 
ATOM   536  N N   . GLN   A 1 81  ? 15.45900  -8.63600  -29.43600 1.000 48.01371 ? 277 GLN   A N   1 
ATOM   537  C CA  . GLN   A 1 81  ? 16.20200  -8.40400  -28.20000 1.000 47.66843 ? 277 GLN   A CA  1 
ATOM   538  C C   . GLN   A 1 81  ? 15.75300  -7.12100  -27.51200 1.000 41.82597 ? 277 GLN   A C   1 
ATOM   539  O O   . GLN   A 1 81  ? 15.50900  -7.11200  -26.30000 1.000 44.63385 ? 277 GLN   A O   1 
ATOM   540  C CB  . GLN   A 1 81  ? 17.70200  -8.35800  -28.49800 1.000 48.84203 ? 277 GLN   A CB  1 
ATOM   541  C CG  . GLN   A 1 81  ? 18.55600  -8.11300  -27.28400 1.000 53.67054 ? 277 GLN   A CG  1 
ATOM   542  C CD  . GLN   A 1 81  ? 19.96100  -8.63500  -27.46100 1.000 56.07169 ? 277 GLN   A CD  1 
ATOM   543  O OE1 . GLN   A 1 81  ? 20.42600  -9.47300  -26.68700 1.000 57.67705 ? 277 GLN   A OE1 1 
ATOM   544  N NE2 . GLN   A 1 81  ? 20.64700  -8.14900  -28.49500 1.000 55.41864 ? 277 GLN   A NE2 1 
ATOM   545  N N   . CYS   A 1 82  ? 15.66100  -6.01600  -28.26400 1.000 44.46602 ? 278 CYS   A N   1 
ATOM   546  C CA  . CYS   A 1 82  ? 15.21600  -4.75200  -27.67700 1.000 42.66649 ? 278 CYS   A CA  1 
ATOM   547  C C   . CYS   A 1 82  ? 13.79100  -4.86300  -27.14600 1.000 45.03692 ? 278 CYS   A C   1 
ATOM   548  O O   . CYS   A 1 82  ? 13.44700  -4.24100  -26.13200 1.000 41.92228 ? 278 CYS   A O   1 
ATOM   549  C CB  . CYS   A 1 82  ? 15.28600  -3.62100  -28.70400 1.000 44.45690 ? 278 CYS   A CB  1 
ATOM   550  S SG  . CYS   A 1 82  ? 16.94400  -3.04600  -29.11400 1.000 60.55124 ? 278 CYS   A SG  1 
ATOM   551  N N   . THR   A 1 83  ? 12.93500  -5.62400  -27.83600 1.000 43.02921 ? 279 THR   A N   1 
ATOM   552  C CA  . THR   A 1 83  ? 11.57000  -5.79500  -27.34900 1.000 41.99579 ? 279 THR   A CA  1 
ATOM   553  C C   . THR   A 1 83  ? 11.56500  -6.51500  -26.01100 1.000 39.46155 ? 279 THR   A C   1 
ATOM   554  O O   . THR   A 1 83  ? 10.93600  -6.05600  -25.05100 1.000 36.29014 ? 279 THR   A O   1 
ATOM   555  C CB  . THR   A 1 83  ? 10.73000  -6.54400  -28.37500 1.000 43.06107 ? 279 THR   A CB  1 
ATOM   556  O OG1 . THR   A 1 83  ? 10.68200  -5.77700  -29.58300 1.000 42.10452 ? 279 THR   A OG1 1 
ATOM   557  C CG2 . THR   A 1 83  ? 9.31900   -6.72700  -27.85000 1.000 34.98614 ? 279 THR   A CG2 1 
ATOM   558  N N   . SER   A 1 84  ? 12.29700  -7.63000  -25.91300 1.000 36.26419 ? 280 SER   A N   1 
ATOM   559  C CA  . SER   A 1 84  ? 12.38200  -8.32100  -24.63700 1.000 36.59758 ? 280 SER   A CA  1 
ATOM   560  C C   . SER   A 1 84  ? 12.90500  -7.38900  -23.55300 1.000 37.59855 ? 280 SER   A C   1 
ATOM   561  O O   . SER   A 1 84  ? 12.39400  -7.38800  -22.42900 1.000 38.52934 ? 280 SER   A O   1 
ATOM   562  C CB  . SER   A 1 84  ? 13.26900  -9.56600  -24.74900 1.000 33.83462 ? 280 SER   A CB  1 
ATOM   563  O OG  . SER   A 1 84  ? 12.73400  -10.49900 -25.67900 1.000 38.95072 ? 280 SER   A OG  1 
ATOM   564  N N   . VAL   A 1 85  ? 13.91700  -6.57600  -23.87200 1.000 38.88257 ? 281 VAL   A N   1 
ATOM   565  C CA  . VAL   A 1 85  ? 14.49200  -5.68200  -22.86500 1.000 40.77107 ? 281 VAL   A CA  1 
ATOM   566  C C   . VAL   A 1 85  ? 13.44600  -4.68200  -22.37300 1.000 41.24798 ? 281 VAL   A C   1 
ATOM   567  O O   . VAL   A 1 85  ? 13.26600  -4.47500  -21.16500 1.000 36.61716 ? 281 VAL   A O   1 
ATOM   568  C CB  . VAL   A 1 85  ? 15.73200  -4.97100  -23.43700 1.000 44.75070 ? 281 VAL   A CB  1 
ATOM   569  C CG1 . VAL   A 1 85  ? 16.05800  -3.71400  -22.61900 1.000 42.86838 ? 281 VAL   A CG1 1 
ATOM   570  C CG2 . VAL   A 1 85  ? 16.91900  -5.94000  -23.48100 1.000 42.47072 ? 281 VAL   A CG2 1 
ATOM   571  N N   . GLU   A 1 86  ? 12.73200  -4.05300  -23.30800 1.000 43.24431 ? 282 GLU   A N   1 
ATOM   572  C CA  . GLU   A 1 86  ? 11.62100  -3.18300  -22.94000 1.000 41.27253 ? 282 GLU   A CA  1 
ATOM   573  C C   . GLU   A 1 86  ? 10.58900  -3.92000  -22.09300 1.000 40.98916 ? 282 GLU   A C   1 
ATOM   574  O O   . GLU   A 1 86  ? 10.07600  -3.38000  -21.10300 1.000 41.65067 ? 282 GLU   A O   1 
ATOM   575  C CB  . GLU   A 1 86  ? 10.96100  -2.63500  -24.20200 1.000 44.40891 ? 282 GLU   A CB  1 
ATOM   576  C CG  . GLU   A 1 86  ? 11.42600  -1.26500  -24.58900 1.000 58.22662 ? 282 GLU   A CG  1 
ATOM   577  C CD  . GLU   A 1 86  ? 11.85300  -0.43900  -23.39100 1.000 61.36521 ? 282 GLU   A CD  1 
ATOM   578  O OE1 . GLU   A 1 86  ? 11.01200  -0.20500  -22.48300 1.000 66.91021 ? 282 GLU   A OE1 1 
ATOM   579  O OE2 . GLU   A 1 86  ? 13.03900  -0.04800  -23.35300 1.000 61.01770 ? 282 GLU   A OE2 1 
ATOM   580  N N   . THR   A 1 87  ? 10.25100  -5.14800  -22.47400 1.000 38.12832 ? 283 THR   A N   1 
ATOM   581  C CA  . THR   A 1 87  ? 9.19800   -5.84300  -21.74900 1.000 40.05599 ? 283 THR   A CA  1 
ATOM   582  C C   . THR   A 1 87  ? 9.63900   -6.22400  -20.33400 1.000 37.14513 ? 283 THR   A C   1 
ATOM   583  O O   . THR   A 1 87  ? 8.80900   -6.26000  -19.41700 1.000 35.75071 ? 283 THR   A O   1 
ATOM   584  C CB  . THR   A 1 87  ? 8.74800   -7.07000  -22.54200 1.000 36.83639 ? 283 THR   A CB  1 
ATOM   585  O OG1 . THR   A 1 87  ? 8.52200   -6.69600  -23.91200 1.000 36.24127 ? 283 THR   A OG1 1 
ATOM   586  C CG2 . THR   A 1 87  ? 7.45600   -7.61200  -21.95100 1.000 36.49450 ? 283 THR   A CG2 1 
ATOM   587  N N   . VAL   A 1 88  ? 10.92600  -6.52200  -20.13600 1.000 36.76157 ? 284 VAL   A N   1 
ATOM   588  C CA  . VAL   A 1 88  ? 11.40000  -6.81300  -18.78800 1.000 36.07275 ? 284 VAL   A CA  1 
ATOM   589  C C   . VAL   A 1 88  ? 11.21000  -5.59400  -17.89600 1.000 36.71655 ? 284 VAL   A C   1 
ATOM   590  O O   . VAL   A 1 88  ? 10.83700  -5.70900  -16.72200 1.000 38.89930 ? 284 VAL   A O   1 
ATOM   591  C CB  . VAL   A 1 88  ? 12.86700  -7.27100  -18.82200 1.000 38.21136 ? 284 VAL   A CB  1 
ATOM   592  C CG1 . VAL   A 1 88  ? 13.45800  -7.32000  -17.38700 1.000 34.90802 ? 284 VAL   A CG1 1 
ATOM   593  C CG2 . VAL   A 1 88  ? 12.97100  -8.62300  -19.49500 1.000 39.43490 ? 284 VAL   A CG2 1 
ATOM   594  N N   . THR   A 1 89  ? 11.44600  -4.40700  -18.44400 1.000 35.16747 ? 285 THR   A N   1 
ATOM   595  C CA  . THR   A 1 89  ? 11.23800  -3.19300  -17.67400 1.000 37.87983 ? 285 THR   A CA  1 
ATOM   596  C C   . THR   A 1 89  ? 9.78000   -3.04700  -17.28300 1.000 36.96280 ? 285 THR   A C   1 
ATOM   597  O O   . THR   A 1 89  ? 9.47100   -2.74000  -16.13000 1.000 39.62134 ? 285 THR   A O   1 
ATOM   598  C CB  . THR   A 1 89  ? 11.70200  -1.98100  -18.47900 1.000 44.91085 ? 285 THR   A CB  1 
ATOM   599  O OG1 . THR   A 1 89  ? 13.08700  -2.13400  -18.80300 1.000 43.93031 ? 285 THR   A OG1 1 
ATOM   600  C CG2 . THR   A 1 89  ? 11.48500  -0.69700  -17.67600 1.000 42.72550 ? 285 THR   A CG2 1 
ATOM   601  N N   . GLU   A 1 90  ? 8.86700   -3.23700  -18.24600 1.000 37.93898 ? 286 GLU   A N   1 
ATOM   602  C CA  . GLU   A 1 90  ? 7.43500   -3.18400  -17.94800 1.000 36.93605 ? 286 GLU   A CA  1 
ATOM   603  C C   . GLU   A 1 90  ? 7.04500   -4.24100  -16.92100 1.000 35.77360 ? 286 GLU   A C   1 
ATOM   604  O O   . GLU   A 1 90  ? 6.22000   -3.98700  -16.03500 1.000 36.68154 ? 286 GLU   A O   1 
ATOM   605  C CB  . GLU   A 1 90  ? 6.63400   -3.38800  -19.23200 1.000 35.30239 ? 286 GLU   A CB  1 
ATOM   606  C CG  . GLU   A 1 90  ? 6.94900   -2.44900  -20.40000 1.000 40.93583 ? 286 GLU   A CG  1 
ATOM   607  C CD  . GLU   A 1 90  ? 5.98900   -2.68400  -21.58300 1.000 47.94188 ? 286 GLU   A CD  1 
ATOM   608  O OE1 . GLU   A 1 90  ? 5.81600   -3.87300  -21.95500 1.000 44.41348 ? 286 GLU   A OE1 1 
ATOM   609  O OE2 . GLU   A 1 90  ? 5.42600   -1.71900  -22.15400 1.000 46.85652 ? 286 GLU   A OE2 1 
ATOM   610  N N   . LEU   A 1 91  ? 7.61500   -5.44400  -17.03900 1.000 34.13932 ? 287 LEU   A N   1 
ATOM   611  C CA  . LEU   A 1 91  ? 7.27100   -6.51200  -16.11300 1.000 37.57063 ? 287 LEU   A CA  1 
ATOM   612  C C   . LEU   A 1 91  ? 7.72500   -6.17400  -14.70800 1.000 34.39609 ? 287 LEU   A C   1 
ATOM   613  O O   . LEU   A 1 91  ? 7.03600   -6.50200  -13.73800 1.000 35.24910 ? 287 LEU   A O   1 
ATOM   614  C CB  . LEU   A 1 91  ? 7.89700   -7.83500  -16.55600 1.000 32.85933 ? 287 LEU   A CB  1 
ATOM   615  C CG  . LEU   A 1 91  ? 7.07300   -8.60700  -17.58900 1.000 32.34016 ? 287 LEU   A CG  1 
ATOM   616  C CD1 . LEU   A 1 91  ? 7.94300   -9.60500  -18.30400 1.000 31.20624 ? 287 LEU   A CD1 1 
ATOM   617  C CD2 . LEU   A 1 91  ? 5.88300   -9.28600  -16.90300 1.000 34.31435 ? 287 LEU   A CD2 1 
ATOM   618  N N   . THR   A 1 92  ? 8.91300   -5.56400  -14.57900 1.000 34.92271 ? 288 THR   A N   1 
ATOM   619  C CA  . THR   A 1 92  ? 9.40800   -5.16100  -13.26000 1.000 37.89645 ? 288 THR   A CA  1 
ATOM   620  C C   . THR   A 1 92  ? 8.47300   -4.15300  -12.61300 1.000 38.07659 ? 288 THR   A C   1 
ATOM   621  O O   . THR   A 1 92  ? 8.12800   -4.27500  -11.42600 1.000 38.24305 ? 288 THR   A O   1 
ATOM   622  C CB  . THR   A 1 92  ? 10.81300  -4.57100  -13.39300 1.000 38.83987 ? 288 THR   A CB  1 
ATOM   623  O OG1 . THR   A 1 92  ? 11.67200  -5.54500  -13.99300 1.000 39.86746 ? 288 THR   A OG1 1 
ATOM   624  C CG2 . THR   A 1 92  ? 11.38100  -4.19300  -12.03600 1.000 41.27139 ? 288 THR   A CG2 1 
ATOM   625  N N   . GLU   A 1 93  ? 8.02900   -3.16100  -13.39500 1.000 34.83644 ? 289 GLU   A N   1 
ATOM   626  C CA  . GLU   A 1 93  ? 7.10000   -2.16200  -12.88200 1.000 39.04337 ? 289 GLU   A CA  1 
ATOM   627  C C   . GLU   A 1 93  ? 5.75500   -2.78600  -12.55700 1.000 37.79315 ? 289 GLU   A C   1 
ATOM   628  O O   . GLU   A 1 93  ? 5.12900   -2.43700  -11.54800 1.000 39.04707 ? 289 GLU   A O   1 
ATOM   629  C CB  . GLU   A 1 93  ? 6.93900   -1.02800  -13.89900 1.000 42.70856 ? 289 GLU   A CB  1 
ATOM   630  C CG  . GLU   A 1 93  ? 8.11900   -0.07100  -13.92700 1.000 46.12045 ? 289 GLU   A CG  1 
ATOM   631  C CD  . GLU   A 1 93  ? 8.30000   0.65700   -12.59200 1.000 53.52678 ? 289 GLU   A CD  1 
ATOM   632  O OE1 . GLU   A 1 93  ? 9.31200   0.39500   -11.90500 1.000 56.71682 ? 289 GLU   A OE1 1 
ATOM   633  O OE2 . GLU   A 1 93  ? 7.43600   1.49100   -12.23400 1.000 57.16204 ? 289 GLU   A OE2 1 
ATOM   634  N N   . PHE   A 1 94  ? 5.29500   -3.71600  -13.39800 1.000 36.51084 ? 290 PHE   A N   1 
ATOM   635  C CA  . PHE   A 1 94  ? 4.07800   -4.46300  -13.09400 1.000 34.57545 ? 290 PHE   A CA  1 
ATOM   636  C C   . PHE   A 1 94  ? 4.22700   -5.21400  -11.76900 1.000 35.62761 ? 290 PHE   A C   1 
ATOM   637  O O   . PHE   A 1 94  ? 3.34600   -5.15000  -10.90400 1.000 32.97326 ? 290 PHE   A O   1 
ATOM   638  C CB  . PHE   A 1 94  ? 3.76200   -5.40700  -14.26400 1.000 33.79681 ? 290 PHE   A CB  1 
ATOM   639  C CG  . PHE   A 1 94  ? 2.62900   -6.36700  -14.01600 1.000 32.09049 ? 290 PHE   A CG  1 
ATOM   640  C CD1 . PHE   A 1 94  ? 1.31000   -5.93400  -14.03700 1.000 30.11347 ? 290 PHE   A CD1 1 
ATOM   641  C CD2 . PHE   A 1 94  ? 2.88700   -7.71800  -13.80000 1.000 29.57039 ? 290 PHE   A CD2 1 
ATOM   642  C CE1 . PHE   A 1 94  ? 0.27200   -6.81900  -13.83100 1.000 34.16475 ? 290 PHE   A CE1 1 
ATOM   643  C CE2 . PHE   A 1 94  ? 1.85200   -8.61800  -13.59900 1.000 30.15260 ? 290 PHE   A CE2 1 
ATOM   644  C CZ  . PHE   A 1 94  ? 0.54300   -8.18200  -13.61300 1.000 33.19886 ? 290 PHE   A CZ  1 
ATOM   645  N N   . ALA   A 1 95  ? 5.36400   -5.89500  -11.57300 1.000 34.73780 ? 291 ALA   A N   1 
ATOM   646  C CA  . ALA   A 1 95  ? 5.54000   -6.69400  -10.35600 1.000 40.50783 ? 291 ALA   A CA  1 
ATOM   647  C C   . ALA   A 1 95  ? 5.52500   -5.81500  -9.11300  1.000 42.01708 ? 291 ALA   A C   1 
ATOM   648  O O   . ALA   A 1 95  ? 4.88400   -6.15500  -8.11400  1.000 39.17989 ? 291 ALA   A O   1 
ATOM   649  C CB  . ALA   A 1 95  ? 6.84000   -7.50200  -10.41400 1.000 35.04845 ? 291 ALA   A CB  1 
ATOM   650  N N   . LYS   A 1 96  ? 6.19300   -4.65700  -9.17900  1.000 37.43131 ? 292 LYS   A N   1 
ATOM   651  C CA  . LYS   A 1 96  ? 6.19700   -3.71500  -8.06600  1.000 42.24942 ? 292 LYS   A CA  1 
ATOM   652  C C   . LYS   A 1 96  ? 4.80000   -3.27600  -7.66800  1.000 38.69891 ? 292 LYS   A C   1 
ATOM   653  O O   . LYS   A 1 96  ? 4.62000   -2.79400  -6.54900  1.000 41.49744 ? 292 LYS   A O   1 
ATOM   654  C CB  . LYS   A 1 96  ? 7.02700   -2.47700  -8.42000  1.000 42.79244 ? 292 LYS   A CB  1 
ATOM   655  C CG  . LYS   A 1 96  ? 8.52900   -2.66300  -8.30600  1.000 43.75473 ? 292 LYS   A CG  1 
ATOM   656  C CD  . LYS   A 1 96  ? 9.25100   -1.33700  -8.57700  1.000 49.51324 ? 292 LYS   A CD  1 
ATOM   657  C CE  . LYS   A 1 96  ? 10.50000  -1.56200  -9.40100  1.000 46.84168 ? 292 LYS   A CE  1 
ATOM   658  N NZ  . LYS   A 1 96  ? 11.06300  -0.29200  -9.95500  1.000 56.00666 ? 292 LYS   A NZ  1 
ATOM   659  N N   . ALA   A 1 97  ? 3.80600   -3.43100  -8.54400  1.000 36.07365 ? 293 ALA   A N   1 
ATOM   660  C CA  . ALA   A 1 97  ? 2.44900   -3.01600  -8.21600  1.000 39.28038 ? 293 ALA   A CA  1 
ATOM   661  C C   . ALA   A 1 97  ? 1.54700   -4.18200  -7.84600  1.000 40.42830 ? 293 ALA   A C   1 
ATOM   662  O O   . ALA   A 1 97  ? 0.36100   -3.97100  -7.57500  1.000 40.77706 ? 293 ALA   A O   1 
ATOM   663  C CB  . ALA   A 1 97  ? 1.83900   -2.22800  -9.36700  1.000 38.15111 ? 293 ALA   A CB  1 
ATOM   664  N N   . ILE   A 1 98  ? 2.08100   -5.39900  -7.80400  1.000 37.11563 ? 294 ILE   A N   1 
ATOM   665  C CA  . ILE   A 1 98  ? 1.32600   -6.55100  -7.32300  1.000 37.84479 ? 294 ILE   A CA  1 
ATOM   666  C C   . ILE   A 1 98  ? 1.33500   -6.49600  -5.79900  1.000 40.30231 ? 294 ILE   A C   1 
ATOM   667  O O   . ILE   A 1 98  ? 2.41900   -6.54400  -5.19700  1.000 39.36207 ? 294 ILE   A O   1 
ATOM   668  C CB  . ILE   A 1 98  ? 1.93300   -7.87800  -7.82300  1.000 37.60562 ? 294 ILE   A CB  1 
ATOM   669  C CG1 . ILE   A 1 98  ? 1.90800   -7.97800  -9.35300  1.000 35.22439 ? 294 ILE   A CG1 1 
ATOM   670  C CG2 . ILE   A 1 98  ? 1.18800   -9.06900  -7.21600  1.000 33.95696 ? 294 ILE   A CG2 1 
ATOM   671  C CD1 . ILE   A 1 98  ? 2.61200   -9.27200  -9.85400  1.000 35.95287 ? 294 ILE   A CD1 1 
ATOM   672  N N   . PRO   A 1 99  ? 0.16600   -6.40400  -5.13300  1.000 42.74344 ? 295 PRO   A N   1 
ATOM   673  C CA  . PRO   A 1 99  ? 0.15100   -6.30800  -3.66200  1.000 41.66712 ? 295 PRO   A CA  1 
ATOM   674  C C   . PRO   A 1 99  ? 1.02300   -7.35700  -3.00200  1.000 46.40230 ? 295 PRO   A C   1 
ATOM   675  O O   . PRO   A 1 99  ? 0.84400   -8.55100  -3.25600  1.000 47.22032 ? 295 PRO   A O   1 
ATOM   676  C CB  . PRO   A 1 99  ? -1.32700  -6.51900  -3.31600  1.000 44.65472 ? 295 PRO   A CB  1 
ATOM   677  C CG  . PRO   A 1 99  ? -2.05600  -5.98200  -4.51600  1.000 44.54203 ? 295 PRO   A CG  1 
ATOM   678  C CD  . PRO   A 1 99  ? -1.19500  -6.37500  -5.70500  1.000 40.88235 ? 295 PRO   A CD  1 
ATOM   679  N N   . GLY   A 1 100 ? 2.00600   -6.93100  -2.20300  1.000 45.17741 ? 296 GLY   A N   1 
ATOM   680  C CA  . GLY   A 1 100 ? 2.90400   -7.83200  -1.50700  1.000 41.93515 ? 296 GLY   A CA  1 
ATOM   681  C C   . GLY   A 1 100 ? 4.30900   -7.86100  -2.07600  1.000 46.11546 ? 296 GLY   A C   1 
ATOM   682  O O   . GLY   A 1 100 ? 5.27200   -8.01900  -1.31800  1.000 47.18061 ? 296 GLY   A O   1 
ATOM   683  N N   . PHE   A 1 101 ? 4.44800   -7.68800  -3.39500  1.000 38.96074 ? 297 PHE   A N   1 
ATOM   684  C CA  . PHE   A 1 101 ? 5.75200   -7.83900  -4.02400  1.000 40.18225 ? 297 PHE   A CA  1 
ATOM   685  C C   . PHE   A 1 101 ? 6.74800   -6.82200  -3.48800  1.000 44.18765 ? 297 PHE   A C   1 
ATOM   686  O O   . PHE   A 1 101 ? 7.92200   -7.15000  -3.26600  1.000 46.01441 ? 297 PHE   A O   1 
ATOM   687  C CB  . PHE   A 1 101 ? 5.61000   -7.70600  -5.54000  1.000 37.28718 ? 297 PHE   A CB  1 
ATOM   688  C CG  . PHE   A 1 101 ? 6.82700   -8.11300  -6.30700  1.000 40.32926 ? 297 PHE   A CG  1 
ATOM   689  C CD1 . PHE   A 1 101 ? 6.93500   -9.39100  -6.83500  1.000 41.77028 ? 297 PHE   A CD1 1 
ATOM   690  C CD2 . PHE   A 1 101 ? 7.85100   -7.20900  -6.53700  1.000 39.84039 ? 297 PHE   A CD2 1 
ATOM   691  C CE1 . PHE   A 1 101 ? 8.04900   -9.76600  -7.55500  1.000 40.10618 ? 297 PHE   A CE1 1 
ATOM   692  C CE2 . PHE   A 1 101 ? 8.96800   -7.57600  -7.26200  1.000 38.80462 ? 297 PHE   A CE2 1 
ATOM   693  C CZ  . PHE   A 1 101 ? 9.07400   -8.85000  -7.76800  1.000 40.87652 ? 297 PHE   A CZ  1 
ATOM   694  N N   . ALA   A 1 102 ? 6.30300   -5.57900  -3.28600  1.000 43.46338 ? 298 ALA   A N   1 
ATOM   695  C CA  . ALA   A 1 102 ? 7.20700   -4.53100  -2.82300  1.000 52.57039 ? 298 ALA   A CA  1 
ATOM   696  C C   . ALA   A 1 102 ? 7.80100   -4.82500  -1.44400  1.000 52.14875 ? 298 ALA   A C   1 
ATOM   697  O O   . ALA   A 1 102 ? 8.85700   -4.27500  -1.10500  1.000 50.07615 ? 298 ALA   A O   1 
ATOM   698  C CB  . ALA   A 1 102 ? 6.47200   -3.18700  -2.79600  1.000 49.45864 ? 298 ALA   A CB  1 
ATOM   699  N N   . ASN   A 1 103 ? 7.15800   -5.67500  -0.64500  1.000 50.45701 ? 299 ASN   A N   1 
ATOM   700  C CA  . ASN   A 1 103 ? 7.65200   -5.96900  0.69400   1.000 49.60972 ? 299 ASN   A CA  1 
ATOM   701  C C   . ASN   A 1 103 ? 8.65500   -7.11500  0.73000   1.000 53.02060 ? 299 ASN   A C   1 
ATOM   702  O O   . ASN   A 1 103 ? 9.25800   -7.35600  1.78300   1.000 50.99690 ? 299 ASN   A O   1 
ATOM   703  C CB  . ASN   A 1 103 ? 6.48500   -6.29700  1.62400   1.000 51.78008 ? 299 ASN   A CB  1 
ATOM   704  C CG  . ASN   A 1 103 ? 5.49500   -5.15100  1.74400   1.000 55.58688 ? 299 ASN   A CG  1 
ATOM   705  O OD1 . ASN   A 1 103 ? 5.87100   -3.97500  1.72200   1.000 57.48138 ? 299 ASN   A OD1 1 
ATOM   706  N ND2 . ASN   A 1 103 ? 4.21800   -5.49200  1.87400   1.000 59.37148 ? 299 ASN   A ND2 1 
ATOM   707  N N   . LEU   A 1 104 ? 8.83200   -7.83800  -0.37200  1.000 50.26794 ? 300 LEU   A N   1 
ATOM   708  C CA  . LEU   A 1 104 ? 9.75800   -8.95600  -0.37200  1.000 47.82966 ? 300 LEU   A CA  1 
ATOM   709  C C   . LEU   A 1 104 ? 11.18500  -8.44000  -0.32500  1.000 50.70046 ? 300 LEU   A C   1 
ATOM   710  O O   . LEU   A 1 104 ? 11.46800  -7.29200  -0.67700  1.000 51.28552 ? 300 LEU   A O   1 
ATOM   711  C CB  . LEU   A 1 104 ? 9.58300   -9.82000  -1.62400  1.000 46.21220 ? 300 LEU   A CB  1 
ATOM   712  C CG  . LEU   A 1 104 ? 8.23400   -10.46500 -1.90500  1.000 48.36763 ? 300 LEU   A CG  1 
ATOM   713  C CD1 . LEU   A 1 104 ? 8.21600   -11.12800 -3.31000  1.000 45.86292 ? 300 LEU   A CD1 1 
ATOM   714  C CD2 . LEU   A 1 104 ? 7.90700   -11.46800 -0.83200  1.000 49.90588 ? 300 LEU   A CD2 1 
ATOM   715  N N   . ASP   A 1 105 ? 12.09100  -9.31400  0.10800   1.000 50.62769 ? 301 ASP   A N   1 
ATOM   716  C CA  . ASP   A 1 105 ? 13.51200  -9.01000  0.03400   1.000 50.44101 ? 301 ASP   A CA  1 
ATOM   717  C C   . ASP   A 1 105 ? 13.93200  -8.74600  -1.41000  1.000 51.64821 ? 301 ASP   A C   1 
ATOM   718  O O   . ASP   A 1 105 ? 13.43200  -9.36900  -2.35200  1.000 50.18330 ? 301 ASP   A O   1 
ATOM   719  C CB  . ASP   A 1 105 ? 14.32800  -10.16900 0.59200   1.000 51.66430 ? 301 ASP   A CB  1 
ATOM   720  C CG  . ASP   A 1 105 ? 15.60400  -9.70600  1.24900   1.000 60.83545 ? 301 ASP   A CG  1 
ATOM   721  O OD1 . ASP   A 1 105 ? 15.52400  -9.02400  2.29700   1.000 65.58160 ? 301 ASP   A OD1 1 
ATOM   722  O OD2 . ASP   A 1 105 ? 16.68600  -9.98700  0.69600   1.000 59.16565 ? 301 ASP   A OD2 1 
ATOM   723  N N   . LEU   A 1 106 ? 14.88400  -7.82700  -1.58000  1.000 51.85025 ? 302 LEU   A N   1 
ATOM   724  C CA  . LEU   A 1 106 ? 15.33400  -7.47700  -2.92300  1.000 48.77654 ? 302 LEU   A CA  1 
ATOM   725  C C   . LEU   A 1 106 ? 15.86300  -8.69300  -3.67500  1.000 49.44145 ? 302 LEU   A C   1 
ATOM   726  O O   . LEU   A 1 106 ? 15.57700  -8.86300  -4.86800  1.000 49.74633 ? 302 LEU   A O   1 
ATOM   727  C CB  . LEU   A 1 106 ? 16.39600  -6.38200  -2.85600  1.000 54.86065 ? 302 LEU   A CB  1 
ATOM   728  C CG  . LEU   A 1 106 ? 15.87500  -4.95200  -3.02100  1.000 64.80284 ? 302 LEU   A CG  1 
ATOM   729  C CD1 . LEU   A 1 106 ? 14.77600  -4.62200  -1.98900  1.000 60.87406 ? 302 LEU   A CD1 1 
ATOM   730  C CD2 . LEU   A 1 106 ? 17.02000  -3.94200  -2.94000  1.000 59.25392 ? 302 LEU   A CD2 1 
ATOM   731  N N   . ASN   A 1 107 ? 16.64400  -9.54800  -3.00400  1.000 48.78558 ? 303 ASN   A N   1 
ATOM   732  C CA  . ASN   A 1 107 ? 17.17500  -10.73100 -3.67700  1.000 49.20276 ? 303 ASN   A CA  1 
ATOM   733  C C   . ASN   A 1 107 ? 16.05700  -11.67500 -4.08100  1.000 48.18539 ? 303 ASN   A C   1 
ATOM   734  O O   . ASN   A 1 107 ? 16.09600  -12.26800 -5.16700  1.000 47.63152 ? 303 ASN   A O   1 
ATOM   735  C CB  . ASN   A 1 107 ? 18.17100  -11.46200 -2.78200  1.000 55.26508 ? 303 ASN   A CB  1 
ATOM   736  C CG  . ASN   A 1 107 ? 19.42100  -10.65400 -2.52600  1.000 61.78820 ? 303 ASN   A CG  1 
ATOM   737  O OD1 . ASN   A 1 107 ? 19.82900  -9.84000  -3.36100  1.000 61.35114 ? 303 ASN   A OD1 1 
ATOM   738  N ND2 . ASN   A 1 107 ? 20.03800  -10.86400 -1.36000  1.000 58.54946 ? 303 ASN   A ND2 1 
ATOM   739  N N   . ASP   A 1 108 ? 15.06300  -11.85000 -3.21100  1.000 44.23113 ? 304 ASP   A N   1 
ATOM   740  C CA  . ASP   A 1 108 ? 13.90600  -12.64200 -3.60500  1.000 47.67300 ? 304 ASP   A CA  1 
ATOM   741  C C   . ASP   A 1 108 ? 13.19000  -11.99600 -4.78600  1.000 43.87164 ? 304 ASP   A C   1 
ATOM   742  O O   . ASP   A 1 108 ? 12.71700  -12.69300 -5.68700  1.000 42.62667 ? 304 ASP   A O   1 
ATOM   743  C CB  . ASP   A 1 108 ? 12.96100  -12.82500 -2.41600  1.000 41.94784 ? 304 ASP   A CB  1 
ATOM   744  C CG  . ASP   A 1 108 ? 13.28100  -14.08100 -1.60100  1.000 48.18378 ? 304 ASP   A CG  1 
ATOM   745  O OD1 . ASP   A 1 108 ? 14.30400  -14.74500 -1.88000  1.000 50.03572 ? 304 ASP   A OD1 1 
ATOM   746  O OD2 . ASP   A 1 108 ? 12.50400  -14.41000 -0.68700  1.000 46.74808 ? 304 ASP   A OD2 1 
ATOM   747  N N   . GLN   A 1 109 ? 13.10900  -10.66100 -4.79900  1.000 44.75363 ? 305 GLN   A N   1 
ATOM   748  C CA  . GLN   A 1 109 ? 12.49500  -9.96300  -5.92700  1.000 43.56563 ? 305 GLN   A CA  1 
ATOM   749  C C   . GLN   A 1 109 ? 13.27100  -10.21400 -7.21300  1.000 43.93224 ? 305 GLN   A C   1 
ATOM   750  O O   . GLN   A 1 109 ? 12.67500  -10.38100 -8.28000  1.000 38.56430 ? 305 GLN   A O   1 
ATOM   751  C CB  . GLN   A 1 109 ? 12.41300  -8.46300  -5.63900  1.000 44.60154 ? 305 GLN   A CB  1 
ATOM   752  C CG  . GLN   A 1 109 ? 11.31000  -8.05500  -4.67500  1.000 44.72869 ? 305 GLN   A CG  1 
ATOM   753  C CD  . GLN   A 1 109 ? 11.41100  -6.58000  -4.23400  1.000 53.46540 ? 305 GLN   A CD  1 
ATOM   754  O OE1 . GLN   A 1 109 ? 12.45400  -5.94200  -4.38400  1.000 53.30127 ? 305 GLN   A OE1 1 
ATOM   755  N NE2 . GLN   A 1 109 ? 10.33200  -6.05400  -3.66300  1.000 50.92885 ? 305 GLN   A NE2 1 
ATOM   756  N N   . VAL   A 1 110 ? 14.60300  -10.26700 -7.12100  1.000 45.27653 ? 306 VAL   A N   1 
ATOM   757  C CA  . VAL   A 1 110 ? 15.44300  -10.51600 -8.29000  1.000 44.41373 ? 306 VAL   A CA  1 
ATOM   758  C C   . VAL   A 1 110 ? 15.23900  -11.93500 -8.79900  1.000 43.56848 ? 306 VAL   A C   1 
ATOM   759  O O   . VAL   A 1 110 ? 15.09200  -12.16300 -10.01000 1.000 39.08865 ? 306 VAL   A O   1 
ATOM   760  C CB  . VAL   A 1 110 ? 16.92400  -10.25100 -7.95300  1.000 44.87563 ? 306 VAL   A CB  1 
ATOM   761  C CG1 . VAL   A 1 110 ? 17.83000  -10.71100 -9.10000  1.000 48.06000 ? 306 VAL   A CG1 1 
ATOM   762  C CG2 . VAL   A 1 110 ? 17.15300  -8.79100  -7.62800  1.000 45.97455 ? 306 VAL   A CG2 1 
ATOM   763  N N   . THR   A 1 111 ? 15.24800  -12.91100 -7.88300  1.000 41.66016 ? 307 THR   A N   1 
ATOM   764  C CA  . THR   A 1 111 ? 14.97300  -14.29900 -8.24800  1.000 40.29264 ? 307 THR   A CA  1 
ATOM   765  C C   . THR   A 1 111 ? 13.64000  -14.43800 -8.97700  1.000 41.33871 ? 307 THR   A C   1 
ATOM   766  O O   . THR   A 1 111 ? 13.56200  -15.07600 -10.03200 1.000 37.18203 ? 307 THR   A O   1 
ATOM   767  C CB  . THR   A 1 111 ? 14.96000  -15.17800 -6.99700  1.000 42.18320 ? 307 THR   A CB  1 
ATOM   768  O OG1 . THR   A 1 111 ? 16.23800  -15.11900 -6.34800  1.000 48.74662 ? 307 THR   A OG1 1 
ATOM   769  C CG2 . THR   A 1 111 ? 14.64500  -16.61900 -7.35600  1.000 43.61718 ? 307 THR   A CG2 1 
ATOM   770  N N   . LEU   A 1 112 ? 12.56800  -13.87000 -8.40800  1.000 39.13706 ? 308 LEU   A N   1 
ATOM   771  C CA  . LEU   A 1 112 ? 11.25100  -14.03100 -9.02000  1.000 38.18104 ? 308 LEU   A CA  1 
ATOM   772  C C   . LEU   A 1 112 ? 11.23800  -13.49200 -10.44400 1.000 36.48165 ? 308 LEU   A C   1 
ATOM   773  O O   . LEU   A 1 112 ? 10.69300  -14.12900 -11.35100 1.000 38.38351 ? 308 LEU   A O   1 
ATOM   774  C CB  . LEU   A 1 112 ? 10.17600  -13.33700 -8.17400  1.000 34.65660 ? 308 LEU   A CB  1 
ATOM   775  C CG  . LEU   A 1 112 ? 9.81200   -14.02800 -6.85800  1.000 40.41465 ? 308 LEU   A CG  1 
ATOM   776  C CD1 . LEU   A 1 112 ? 8.66300   -13.30600 -6.15500  1.000 34.11422 ? 308 LEU   A CD1 1 
ATOM   777  C CD2 . LEU   A 1 112 ? 9.48900   -15.51000 -7.07600  1.000 37.89608 ? 308 LEU   A CD2 1 
ATOM   778  N N   . LEU   A 1 113 ? 11.82200  -12.31300 -10.66000 1.000 38.68456 ? 309 LEU   A N   1 
ATOM   779  C CA  . LEU   A 1 113 ? 11.84400  -11.75300 -12.00600 1.000 36.53160 ? 309 LEU   A CA  1 
ATOM   780  C C   . LEU   A 1 113 ? 12.75100  -12.56600 -12.92100 1.000 37.68385 ? 309 LEU   A C   1 
ATOM   781  O O   . LEU   A 1 113 ? 12.36800  -12.89700 -14.05100 1.000 36.94437 ? 309 LEU   A O   1 
ATOM   782  C CB  . LEU   A 1 113 ? 12.28700  -10.28800 -11.95200 1.000 39.83691 ? 309 LEU   A CB  1 
ATOM   783  C CG  . LEU   A 1 113 ? 11.22900  -9.29200  -11.46300 1.000 43.61272 ? 309 LEU   A CG  1 
ATOM   784  C CD1 . LEU   A 1 113 ? 11.88300  -7.96000  -11.13700 1.000 45.82494 ? 309 LEU   A CD1 1 
ATOM   785  C CD2 . LEU   A 1 113 ? 10.11800  -9.10000  -12.51600 1.000 39.36922 ? 309 LEU   A CD2 1 
ATOM   786  N N   . LYS   A 1 114 ? 13.94100  -12.92600 -12.43800 1.000 37.56859 ? 310 LYS   A N   1 
ATOM   787  C CA  . LYS   A 1 114 ? 14.90400  -13.63600 -13.27900 1.000 42.80865 ? 310 LYS   A CA  1 
ATOM   788  C C   . LYS   A 1 114 ? 14.29900  -14.90600 -13.86100 1.000 40.78957 ? 310 LYS   A C   1 
ATOM   789  O O   . LYS   A 1 114 ? 14.42200  -15.17400 -15.05700 1.000 44.42297 ? 310 LYS   A O   1 
ATOM   790  C CB  . LYS   A 1 114 ? 16.16400  -13.96200 -12.47200 1.000 45.99480 ? 310 LYS   A CB  1 
ATOM   791  C CG  . LYS   A 1 114 ? 17.06200  -15.03400 -13.10000 1.000 49.32554 ? 310 LYS   A CG  1 
ATOM   792  C CD  . LYS   A 1 114 ? 18.23300  -15.36400 -12.15900 1.000 51.64426 ? 310 LYS   A CD  1 
ATOM   793  C CE  . LYS   A 1 114 ? 19.21400  -16.34200 -12.79700 1.000 57.63101 ? 310 LYS   A CE  1 
ATOM   794  N NZ  . LYS   A 1 114 ? 20.18800  -15.65000 -13.68200 1.000 60.84156 ? 310 LYS   A NZ  1 
ATOM   795  N N   . TYR   A 1 115 ? 13.62200  -15.69700 -13.03600 1.000 43.04441 ? 311 TYR   A N   1 
ATOM   796  C CA  . TYR   A 1 115 ? 13.03900  -16.92700 -13.55400 1.000 40.54130 ? 311 TYR   A CA  1 
ATOM   797  C C   . TYR   A 1 115 ? 11.63300  -16.74500 -14.10800 1.000 41.08958 ? 311 TYR   A C   1 
ATOM   798  O O   . TYR   A 1 115 ? 11.13500  -17.64500 -14.77900 1.000 46.32247 ? 311 TYR   A O   1 
ATOM   799  C CB  . TYR   A 1 115 ? 13.04300  -18.00600 -12.45900 1.000 50.78085 ? 311 TYR   A CB  1 
ATOM   800  C CG  . TYR   A 1 115 ? 14.45300  -18.46800 -12.11000 1.000 49.14586 ? 311 TYR   A CG  1 
ATOM   801  C CD1 . TYR   A 1 115 ? 15.09800  -19.45200 -12.86100 1.000 51.73171 ? 311 TYR   A CD1 1 
ATOM   802  C CD2 . TYR   A 1 115 ? 15.14400  -17.89500 -11.05100 1.000 51.51393 ? 311 TYR   A CD2 1 
ATOM   803  C CE1 . TYR   A 1 115 ? 16.39200  -19.86000 -12.54600 1.000 57.91735 ? 311 TYR   A CE1 1 
ATOM   804  C CE2 . TYR   A 1 115 ? 16.43700  -18.29600 -10.72700 1.000 55.23271 ? 311 TYR   A CE2 1 
ATOM   805  C CZ  . TYR   A 1 115 ? 17.05300  -19.27200 -11.47600 1.000 62.67841 ? 311 TYR   A CZ  1 
ATOM   806  O OH  . TYR   A 1 115 ? 18.33500  -19.65100 -11.14100 1.000 70.45187 ? 311 TYR   A OH  1 
ATOM   807  N N   . GLY   A 1 116 ? 10.99400  -15.60300 -13.88700 1.000 40.94862 ? 312 GLY   A N   1 
ATOM   808  C CA  . GLY   A 1 116 ? 9.62000   -15.44400 -14.32300 1.000 37.58993 ? 312 GLY   A CA  1 
ATOM   809  C C   . GLY   A 1 116 ? 9.38300   -14.65000 -15.59700 1.000 36.11618 ? 312 GLY   A C   1 
ATOM   810  O O   . GLY   A 1 116 ? 8.35400   -14.85400 -16.25100 1.000 34.21847 ? 312 GLY   A O   1 
ATOM   811  N N   . VAL   A 1 117 ? 10.31000  -13.77500 -16.00000 1.000 33.88249 ? 313 VAL   A N   1 
ATOM   812  C CA  . VAL   A 1 117 ? 9.97000   -12.80800 -17.04700 1.000 36.64248 ? 313 VAL   A CA  1 
ATOM   813  C C   . VAL   A 1 117 ? 9.74900   -13.49700 -18.38300 1.000 35.37179 ? 313 VAL   A C   1 
ATOM   814  O O   . VAL   A 1 117 ? 8.85300   -13.10800 -19.14400 1.000 35.82767 ? 313 VAL   A O   1 
ATOM   815  C CB  . VAL   A 1 117 ? 11.02900  -11.70000 -17.17600 1.000 36.82220 ? 313 VAL   A CB  1 
ATOM   816  C CG1 . VAL   A 1 117 ? 10.95000  -10.75900 -15.96800 1.000 38.21883 ? 313 VAL   A CG1 1 
ATOM   817  C CG2 . VAL   A 1 117 ? 12.41300  -12.30500 -17.36900 1.000 37.72687 ? 313 VAL   A CG2 1 
ATOM   818  N N   . TYR   A 1 118 ? 10.54200  -14.52900 -18.70400 1.000 34.59134 ? 314 TYR   A N   1 
ATOM   819  C CA  . TYR   A 1 118 ? 10.37800  -15.11800 -20.03300 1.000 36.43144 ? 314 TYR   A CA  1 
ATOM   820  C C   . TYR   A 1 118 ? 9.13800   -15.99000 -20.12100 1.000 32.83120 ? 314 TYR   A C   1 
ATOM   821  O O   . TYR   A 1 118 ? 8.54600   -16.10400 -21.19500 1.000 33.13918 ? 314 TYR   A O   1 
ATOM   822  C CB  . TYR   A 1 118 ? 11.63800  -15.90300 -20.45800 1.000 37.82475 ? 314 TYR   A CB  1 
ATOM   823  C CG  . TYR   A 1 118 ? 12.62700  -14.95500 -21.08500 1.000 42.12876 ? 314 TYR   A CG  1 
ATOM   824  C CD1 . TYR   A 1 118 ? 12.44000  -14.49000 -22.38800 1.000 36.05910 ? 314 TYR   A CD1 1 
ATOM   825  C CD2 . TYR   A 1 118 ? 13.68500  -14.43700 -20.34200 1.000 40.51826 ? 314 TYR   A CD2 1 
ATOM   826  C CE1 . TYR   A 1 118 ? 13.31100  -13.59500 -22.95200 1.000 41.51808 ? 314 TYR   A CE1 1 
ATOM   827  C CE2 . TYR   A 1 118 ? 14.56400  -13.51900 -20.89500 1.000 38.94872 ? 314 TYR   A CE2 1 
ATOM   828  C CZ  . TYR   A 1 118 ? 14.37700  -13.11200 -22.20500 1.000 44.12534 ? 314 TYR   A CZ  1 
ATOM   829  O OH  . TYR   A 1 118 ? 15.24000  -12.20800 -22.77200 1.000 43.84506 ? 314 TYR   A OH  1 
ATOM   830  N N   . GLU   A 1 119 ? 8.70800   -16.60700 -19.02800 1.000 33.87481 ? 315 GLU   A N   1 
ATOM   831  C CA  . GLU   A 1 119 ? 7.40400   -17.26300 -19.09700 1.000 33.99842 ? 315 GLU   A CA  1 
ATOM   832  C C   . GLU   A 1 119 ? 6.31100   -16.23700 -19.35300 1.000 31.64382 ? 315 GLU   A C   1 
ATOM   833  O O   . GLU   A 1 119 ? 5.39200   -16.47800 -20.14600 1.000 32.80735 ? 315 GLU   A O   1 
ATOM   834  C CB  . GLU   A 1 119 ? 7.13500   -18.04000 -17.82200 1.000 32.16324 ? 315 GLU   A CB  1 
ATOM   835  C CG  . GLU   A 1 119 ? 8.10100   -19.23900 -17.62400 1.000 39.98213 ? 315 GLU   A CG  1 
ATOM   836  C CD  . GLU   A 1 119 ? 7.97800   -19.82100 -16.22600 1.000 43.44317 ? 315 GLU   A CD  1 
ATOM   837  O OE1 . GLU   A 1 119 ? 8.95800   -20.38600 -15.70000 1.000 49.96686 ? 315 GLU   A OE1 1 
ATOM   838  O OE2 . GLU   A 1 119 ? 6.89900   -19.65300 -15.63100 1.000 42.26742 ? 315 GLU   A OE2 1 
ATOM   839  N N   . ALA   A 1 120 ? 6.42000   -15.06300 -18.71700 1.000 32.54760 ? 316 ALA   A N   1 
ATOM   840  C CA  . ALA   A 1 120 ? 5.43400   -14.00200 -18.93000 1.000 31.89802 ? 316 ALA   A CA  1 
ATOM   841  C C   . ALA   A 1 120 ? 5.50900   -13.44400 -20.34600 1.000 30.26230 ? 316 ALA   A C   1 
ATOM   842  O O   . ALA   A 1 120 ? 4.47600   -13.20800 -20.98100 1.000 32.17738 ? 316 ALA   A O   1 
ATOM   843  C CB  . ALA   A 1 120 ? 5.66000   -12.87800 -17.91200 1.000 30.87500 ? 316 ALA   A CB  1 
ATOM   844  N N   . ILE   A 1 121 ? 6.72500   -13.19600 -20.84400 1.000 31.02607 ? 317 ILE   A N   1 
ATOM   845  C CA  . ILE   A 1 121 ? 6.89700   -12.65600 -22.18600 1.000 29.70613 ? 317 ILE   A CA  1 
ATOM   846  C C   . ILE   A 1 121 ? 6.26800   -13.57900 -23.21900 1.000 32.34014 ? 317 ILE   A C   1 
ATOM   847  O O   . ILE   A 1 121 ? 5.54000   -13.12200 -24.10600 1.000 30.27345 ? 317 ILE   A O   1 
ATOM   848  C CB  . ILE   A 1 121 ? 8.38800   -12.41600 -22.48100 1.000 33.60905 ? 317 ILE   A CB  1 
ATOM   849  C CG1 . ILE   A 1 121 ? 8.81000   -11.06000 -21.92500 1.000 34.60220 ? 317 ILE   A CG1 1 
ATOM   850  C CG2 . ILE   A 1 121 ? 8.67700   -12.51000 -23.98000 1.000 31.80249 ? 317 ILE   A CG2 1 
ATOM   851  C CD1 . ILE   A 1 121 ? 10.29400  -10.94600 -21.63500 1.000 38.68990 ? 317 ILE   A CD1 1 
ATOM   852  N N   . PHE   A 1 122 ? 6.52700   -14.89900 -23.12400 1.000 29.74458 ? 318 PHE   A N   1 
ATOM   853  C CA  . PHE   A 1 122 ? 5.98500   -15.79200 -24.14700 1.000 29.94756 ? 318 PHE   A CA  1 
ATOM   854  C C   . PHE   A 1 122 ? 4.48100   -15.98300 -23.97300 1.000 30.56040 ? 318 PHE   A C   1 
ATOM   855  O O   . PHE   A 1 122 ? 3.77300   -16.19000 -24.96400 1.000 31.07192 ? 318 PHE   A O   1 
ATOM   856  C CB  . PHE   A 1 122 ? 6.73900   -17.13600 -24.14900 1.000 30.60919 ? 318 PHE   A CB  1 
ATOM   857  C CG  . PHE   A 1 122 ? 8.18300   -17.00400 -24.59400 1.000 35.70636 ? 318 PHE   A CG  1 
ATOM   858  C CD1 . PHE   A 1 122 ? 8.51100   -16.17900 -25.65700 1.000 35.12940 ? 318 PHE   A CD1 1 
ATOM   859  C CD2 . PHE   A 1 122 ? 9.20700   -17.64100 -23.91200 1.000 37.60166 ? 318 PHE   A CD2 1 
ATOM   860  C CE1 . PHE   A 1 122 ? 9.84500   -15.99800 -26.06000 1.000 37.86852 ? 318 PHE   A CE1 1 
ATOM   861  C CE2 . PHE   A 1 122 ? 10.53800  -17.47600 -24.30600 1.000 42.22940 ? 318 PHE   A CE2 1 
ATOM   862  C CZ  . PHE   A 1 122 ? 10.85600  -16.65100 -25.39200 1.000 39.57549 ? 318 PHE   A CZ  1 
ATOM   863  N N   . ALA   A 1 123 ? 3.96400   -15.85400 -22.74100 1.000 28.86267 ? 319 ALA   A N   1 
ATOM   864  C CA  . ALA   A 1 123 ? 2.51100   -15.77300 -22.55700 1.000 28.18973 ? 319 ALA   A CA  1 
ATOM   865  C C   . ALA   A 1 123 ? 1.92700   -14.55800 -23.27700 1.000 35.08608 ? 319 ALA   A C   1 
ATOM   866  O O   . ALA   A 1 123 ? 0.95400   -14.67300 -24.03800 1.000 30.98025 ? 319 ALA   A O   1 
ATOM   867  C CB  . ALA   A 1 123 ? 2.17600   -15.71400 -21.06300 1.000 29.13171 ? 319 ALA   A CB  1 
ATOM   868  N N   . MET   A 1 124 ? 2.51000   -13.37600 -23.04300 1.000 27.45001 ? 320 MET   A N   1 
ATOM   869  C CA  . MET   A 1 124 ? 2.00100   -12.14400 -23.64700 1.000 28.48274 ? 320 MET   A CA  1 
ATOM   870  C C   . MET   A 1 124 ? 2.28600   -12.04600 -25.14400 1.000 31.16904 ? 320 MET   A C   1 
ATOM   871  O O   . MET   A 1 124 ? 1.52100   -11.38600 -25.87300 1.000 29.82775 ? 320 MET   A O   1 
ATOM   872  C CB  . MET   A 1 124 ? 2.58500   -10.94500 -22.88500 1.000 28.09252 ? 320 MET   A CB  1 
ATOM   873  C CG  . MET   A 1 124 ? 2.12800   -10.91000 -21.38700 1.000 30.52341 ? 320 MET   A CG  1 
ATOM   874  S SD  . MET   A 1 124 ? 2.59000   -9.32400  -20.66000 1.000 36.28873 ? 320 MET   A SD  1 
ATOM   875  C CE  . MET   A 1 124 ? 4.31300   -9.70700  -20.41600 1.000 34.68426 ? 320 MET   A CE  1 
ATOM   876  N N   . LEU   A 1 125 ? 3.37700   -12.66700 -25.61200 1.000 30.62900 ? 321 LEU   A N   1 
ATOM   877  C CA  . LEU   A 1 125 ? 3.68000   -12.72600 -27.04200 1.000 30.22901 ? 321 LEU   A CA  1 
ATOM   878  C C   . LEU   A 1 125 ? 2.50300   -13.28900 -27.82600 1.000 28.72054 ? 321 LEU   A C   1 
ATOM   879  O O   . LEU   A 1 125 ? 2.23000   -12.86700 -28.95700 1.000 30.67735 ? 321 LEU   A O   1 
ATOM   880  C CB  . LEU   A 1 125 ? 4.93700   -13.58900 -27.27000 1.000 30.51507 ? 321 LEU   A CB  1 
ATOM   881  C CG  . LEU   A 1 125 ? 5.42000   -13.78500 -28.71500 1.000 30.31361 ? 321 LEU   A CG  1 
ATOM   882  C CD1 . LEU   A 1 125 ? 5.83300   -12.45900 -29.33200 1.000 30.00524 ? 321 LEU   A CD1 1 
ATOM   883  C CD2 . LEU   A 1 125 ? 6.60800   -14.74700 -28.76900 1.000 32.42160 ? 321 LEU   A CD2 1 
ATOM   884  N N   . SER   A 1 126 ? 1.78000   -14.23200 -27.22600 1.000 28.45202 ? 322 SER   A N   1 
ATOM   885  C CA  . SER   A 1 126 ? 0.64800   -14.83900 -27.90400 1.000 34.72167 ? 322 SER   A CA  1 
ATOM   886  C C   . SER   A 1 126 ? -0.38800  -13.80500 -28.32200 1.000 35.11369 ? 322 SER   A C   1 
ATOM   887  O O   . SER   A 1 126 ? -1.05200  -13.97100 -29.35600 1.000 34.29532 ? 322 SER   A O   1 
ATOM   888  C CB  . SER   A 1 126 ? 0.01800   -15.88500 -26.98700 1.000 35.30484 ? 322 SER   A CB  1 
ATOM   889  O OG  . SER   A 1 126 ? 1.01200   -16.73900 -26.44900 1.000 38.24879 ? 322 SER   A OG  1 
ATOM   890  N N   . SER   A 1 127 ? -0.53100  -12.73400 -27.54200 1.000 32.50342 ? 323 SER   A N   1 
ATOM   891  C CA  . SER   A 1 127 ? -1.53200  -11.71100 -27.84100 1.000 35.61067 ? 323 SER   A CA  1 
ATOM   892  C C   . SER   A 1 127 ? -1.23200  -10.96800 -29.13200 1.000 34.45831 ? 323 SER   A C   1 
ATOM   893  O O   . SER   A 1 127 ? -2.15900  -10.45400 -29.76500 1.000 35.41855 ? 323 SER   A O   1 
ATOM   894  C CB  . SER   A 1 127 ? -1.63000  -10.68100 -26.71300 1.000 32.38096 ? 323 SER   A CB  1 
ATOM   895  O OG  . SER   A 1 127 ? -2.05400  -11.22000 -25.49400 1.000 36.90603 ? 323 SER   A OG  1 
ATOM   896  N N   . VAL   A 1 128 ? 0.04100   -10.83900 -29.50900 1.000 32.46212 ? 324 VAL   A N   1 
ATOM   897  C CA  . VAL   A 1 128 ? 0.39500   -10.11200 -30.71900 1.000 32.81846 ? 324 VAL   A CA  1 
ATOM   898  C C   . VAL   A 1 128 ? 0.61200   -11.05000 -31.91000 1.000 40.74484 ? 324 VAL   A C   1 
ATOM   899  O O   . VAL   A 1 128 ? 1.13600   -10.61500 -32.94400 1.000 37.95330 ? 324 VAL   A O   1 
ATOM   900  C CB  . VAL   A 1 128 ? 1.62000   -9.20000  -30.48700 1.000 36.01612 ? 324 VAL   A CB  1 
ATOM   901  C CG1 . VAL   A 1 128 ? 1.42000   -8.38500  -29.21000 1.000 39.70872 ? 324 VAL   A CG1 1 
ATOM   902  C CG2 . VAL   A 1 128 ? 2.93200   -9.96700  -30.40000 1.000 32.89553 ? 324 VAL   A CG2 1 
ATOM   903  N N   . MET   A 1 129 ? 0.21200   -12.32300 -31.79100 1.000 35.59698 ? 325 MET   A N   1 
ATOM   904  C CA  . MET   A 1 129 ? 0.36500   -13.31300 -32.85000 1.000 37.95449 ? 325 MET   A CA  1 
ATOM   905  C C   . MET   A 1 129 ? -0.98800  -13.72700 -33.40200 1.000 40.39493 ? 325 MET   A C   1 
ATOM   906  O O   . MET   A 1 129 ? -1.98200  -13.79300 -32.67400 1.000 40.85188 ? 325 MET   A O   1 
ATOM   907  C CB  . MET   A 1 129 ? 1.07200   -14.60000 -32.37600 1.000 34.69869 ? 325 MET   A CB  1 
ATOM   908  C CG  . MET   A 1 129 ? 2.55600   -14.44200 -32.14600 1.000 36.94352 ? 325 MET   A CG  1 
ATOM   909  S SD  . MET   A 1 129 ? 3.33900   -15.85300 -31.33000 1.000 35.02785 ? 325 MET   A SD  1 
ATOM   910  C CE  . MET   A 1 129 ? 4.98200   -15.66500 -32.00900 1.000 33.96786 ? 325 MET   A CE  1 
ATOM   911  N N   . ASN   A 1 130 ? -1.01100  -14.01400 -34.70200 1.000 43.65356 ? 326 ASN   A N   1 
ATOM   912  C CA  . ASN   A 1 130 ? -2.04400  -14.89500 -35.23200 1.000 45.84390 ? 326 ASN   A CA  1 
ATOM   913  C C   . ASN   A 1 130 ? -1.35300  -15.99700 -36.02600 1.000 46.05981 ? 326 ASN   A C   1 
ATOM   914  O O   . ASN   A 1 130 ? -0.12100  -16.11100 -35.97300 1.000 42.89000 ? 326 ASN   A O   1 
ATOM   915  C CB  . ASN   A 1 130 ? -3.07600  -14.12400 -36.06300 1.000 43.33929 ? 326 ASN   A CB  1 
ATOM   916  C CG  . ASN   A 1 130 ? -2.50200  -13.51300 -37.33900 1.000 44.61797 ? 326 ASN   A CG  1 
ATOM   917  O OD1 . ASN   A 1 130 ? -1.42400  -13.87700 -37.81300 1.000 42.95289 ? 326 ASN   A OD1 1 
ATOM   918  N ND2 . ASN   A 1 130 ? -3.25400  -12.57400 -37.91200 1.000 47.55230 ? 326 ASN   A ND2 1 
ATOM   919  N N   . LYS   A 1 131 ? -2.11600  -16.80900 -36.76500 1.000 44.56407 ? 327 LYS   A N   1 
ATOM   920  C CA  . LYS   A 1 131 ? -1.50200  -17.95700 -37.43300 1.000 50.07394 ? 327 LYS   A CA  1 
ATOM   921  C C   . LYS   A 1 131 ? -0.48700  -17.54500 -38.49800 1.000 46.88057 ? 327 LYS   A C   1 
ATOM   922  O O   . LYS   A 1 131 ? 0.42100   -18.32600 -38.80200 1.000 46.08373 ? 327 LYS   A O   1 
ATOM   923  C CB  . LYS   A 1 131 ? -2.57800  -18.86700 -38.04600 1.000 53.34539 ? 327 LYS   A CB  1 
ATOM   924  C CG  . LYS   A 1 131 ? -3.51600  -18.18300 -39.04900 1.000 58.13319 ? 327 LYS   A CG  1 
ATOM   925  C CD  . LYS   A 1 131 ? -4.52400  -19.17600 -39.65700 1.000 59.66343 ? 327 LYS   A CD  1 
ATOM   926  C CE  . LYS   A 1 131 ? -3.81300  -20.38600 -40.26500 1.000 61.81878 ? 327 LYS   A CE  1 
ATOM   927  N NZ  . LYS   A 1 131 ? -4.55600  -21.68100 -40.08400 1.000 69.10782 ? 327 LYS   A NZ  1 
ATOM   928  N N   . ASP   A 1 132 ? -0.57500  -16.32200 -39.02500 1.000 45.35191 ? 328 ASP   A N   1 
ATOM   929  C CA  . ASP   A 1 132 ? 0.26000   -15.89900 -40.14200 1.000 42.38587 ? 328 ASP   A CA  1 
ATOM   930  C C   . ASP   A 1 132 ? 1.47700   -15.04900 -39.76000 1.000 47.52929 ? 328 ASP   A C   1 
ATOM   931  O O   . ASP   A 1 132 ? 2.32300   -14.78700 -40.62900 1.000 42.21398 ? 328 ASP   A O   1 
ATOM   932  C CB  . ASP   A 1 132 ? -0.60000  -15.11900 -41.14000 1.000 48.81621 ? 328 ASP   A CB  1 
ATOM   933  C CG  . ASP   A 1 132 ? -1.69600  -15.97900 -41.76100 1.000 58.22936 ? 328 ASP   A CG  1 
ATOM   934  O OD1 . ASP   A 1 132 ? -1.46200  -17.19500 -41.95800 1.000 59.92904 ? 328 ASP   A OD1 1 
ATOM   935  O OD2 . ASP   A 1 132 ? -2.79400  -15.44600 -42.03900 1.000 58.90580 ? 328 ASP   A OD2 1 
ATOM   936  N N   . GLY   A 1 133 ? 1.58900   -14.58300 -38.51900 1.000 39.86727 ? 329 GLY   A N   1 
ATOM   937  C CA  . GLY   A 1 133 ? 2.70000   -13.72300 -38.17300 1.000 37.85178 ? 329 GLY   A CA  1 
ATOM   938  C C   . GLY   A 1 133 ? 2.45100   -13.00500 -36.85500 1.000 40.67026 ? 329 GLY   A C   1 
ATOM   939  O O   . GLY   A 1 133 ? 1.50300   -13.30900 -36.12400 1.000 36.70574 ? 329 GLY   A O   1 
ATOM   940  N N   . MET   A 1 134 ? 3.31400   -12.03300 -36.58000 1.000 37.26285 ? 330 MET   A N   1 
ATOM   941  C CA  . MET   A 1 134 ? 3.32200   -11.33500 -35.30000 1.000 35.67345 ? 330 MET   A CA  1 
ATOM   942  C C   . MET   A 1 134 ? 3.59900   -9.84400  -35.47800 1.000 38.68463 ? 330 MET   A C   1 
ATOM   943  O O   . MET   A 1 134 ? 4.38000   -9.43900  -36.35000 1.000 36.09902 ? 330 MET   A O   1 
ATOM   944  C CB  . MET   A 1 134 ? 4.35300   -11.97600 -34.36400 1.000 34.88183 ? 330 MET   A CB  1 
ATOM   945  C CG  . MET   A 1 134 ? 5.78000   -11.61700 -34.68200 1.000 38.78940 ? 330 MET   A CG  1 
ATOM   946  S SD  . MET   A 1 134 ? 7.03200   -12.47300 -33.70700 1.000 45.25809 ? 330 MET   A SD  1 
ATOM   947  C CE  . MET   A 1 134 ? 7.30400   -11.23100 -32.45600 1.000 39.91163 ? 330 MET   A CE  1 
ATOM   948  N N   . LEU   A 1 135 ? 2.94700   -9.03500  -34.63800 1.000 36.28810 ? 331 LEU   A N   1 
ATOM   949  C CA  . LEU   A 1 135 ? 3.16700   -7.59700  -34.63300 1.000 33.74478 ? 331 LEU   A CA  1 
ATOM   950  C C   . LEU   A 1 135 ? 4.53700   -7.27900  -34.06500 1.000 35.66358 ? 331 LEU   A C   1 
ATOM   951  O O   . LEU   A 1 135 ? 5.02600   -7.94700  -33.15600 1.000 36.59038 ? 331 LEU   A O   1 
ATOM   952  C CB  . LEU   A 1 135 ? 2.09800   -6.88900  -33.80200 1.000 36.81364 ? 331 LEU   A CB  1 
ATOM   953  C CG  . LEU   A 1 135 ? 0.65800   -6.99400  -34.28900 1.000 37.79782 ? 331 LEU   A CG  1 
ATOM   954  C CD1 . LEU   A 1 135 ? -0.29400  -6.44000  -33.25100 1.000 42.76309 ? 331 LEU   A CD1 1 
ATOM   955  C CD2 . LEU   A 1 135 ? 0.51400   -6.24700  -35.60600 1.000 43.32249 ? 331 LEU   A CD2 1 
ATOM   956  N N   . VAL   A 1 136 ? 5.16000   -6.23400  -34.61200 1.000 35.01389 ? 332 VAL   A N   1 
ATOM   957  C CA  . VAL   A 1 136 ? 6.43600   -5.72900  -34.13300 1.000 34.43202 ? 332 VAL   A CA  1 
ATOM   958  C C   . VAL   A 1 136 ? 6.41100   -4.21500  -34.23500 1.000 33.63730 ? 332 VAL   A C   1 
ATOM   959  O O   . VAL   A 1 136 ? 5.54600   -3.62600  -34.88500 1.000 34.86394 ? 332 VAL   A O   1 
ATOM   960  C CB  . VAL   A 1 136 ? 7.63300   -6.28300  -34.93100 1.000 37.26039 ? 332 VAL   A CB  1 
ATOM   961  C CG1 . VAL   A 1 136 ? 7.73500   -7.78400  -34.76700 1.000 40.50615 ? 332 VAL   A CG1 1 
ATOM   962  C CG2 . VAL   A 1 136 ? 7.49500   -5.89100  -36.40400 1.000 35.45696 ? 332 VAL   A CG2 1 
ATOM   963  N N   . ALA   A 1 137 ? 7.37300   -3.59000  -33.56000 1.000 37.26453 ? 333 ALA   A N   1 
ATOM   964  C CA  . ALA   A 1 137 ? 7.61900   -2.15100  -33.66000 1.000 39.65264 ? 333 ALA   A CA  1 
ATOM   965  C C   . ALA   A 1 137 ? 6.41300   -1.35800  -33.17200 1.000 38.17910 ? 333 ALA   A C   1 
ATOM   966  O O   . ALA   A 1 137 ? 5.87100   -0.50500  -33.88500 1.000 36.70412 ? 333 ALA   A O   1 
ATOM   967  C CB  . ALA   A 1 137 ? 7.99000   -1.75100  -35.09200 1.000 40.10349 ? 333 ALA   A CB  1 
ATOM   968  N N   . TYR   A 1 138 ? 5.98400   -1.67000  -31.94600 1.000 36.93896 ? 334 TYR   A N   1 
ATOM   969  C CA  . TYR   A 1 138 ? 4.85600   -0.99900  -31.29100 1.000 39.79332 ? 334 TYR   A CA  1 
ATOM   970  C C   . TYR   A 1 138 ? 3.58700   -1.08900  -32.13200 1.000 41.00473 ? 334 TYR   A C   1 
ATOM   971  O O   . TYR   A 1 138 ? 2.79200   -0.15300  -32.18400 1.000 41.84677 ? 334 TYR   A O   1 
ATOM   972  C CB  . TYR   A 1 138 ? 5.20900   0.45900   -30.95500 1.000 38.39810 ? 334 TYR   A CB  1 
ATOM   973  C CG  . TYR   A 1 138 ? 6.40400   0.52300   -30.02900 1.000 41.57069 ? 334 TYR   A CG  1 
ATOM   974  C CD1 . TYR   A 1 138 ? 6.25400   0.32200   -28.66500 1.000 43.72641 ? 334 TYR   A CD1 1 
ATOM   975  C CD2 . TYR   A 1 138 ? 7.68700   0.71400   -30.52400 1.000 42.52414 ? 334 TYR   A CD2 1 
ATOM   976  C CE1 . TYR   A 1 138 ? 7.33600   0.33900   -27.81600 1.000 43.30951 ? 334 TYR   A CE1 1 
ATOM   977  C CE2 . TYR   A 1 138 ? 8.78100   0.73600   -29.67800 1.000 46.39147 ? 334 TYR   A CE2 1 
ATOM   978  C CZ  . TYR   A 1 138 ? 8.59800   0.54900   -28.32700 1.000 49.59391 ? 334 TYR   A CZ  1 
ATOM   979  O OH  . TYR   A 1 138 ? 9.68800   0.57100   -27.47900 1.000 56.73322 ? 334 TYR   A OH  1 
ATOM   980  N N   . GLY   A 1 139 ? 3.39200   -2.22700  -32.80100 1.000 39.87570 ? 335 GLY   A N   1 
ATOM   981  C CA  . GLY   A 1 139 ? 2.19300   -2.43500  -33.58000 1.000 31.13903 ? 335 GLY   A CA  1 
ATOM   982  C C   . GLY   A 1 139 ? 2.22100   -1.85100  -34.97300 1.000 40.61189 ? 335 GLY   A C   1 
ATOM   983  O O   . GLY   A 1 139 ? 1.22000   -1.96200  -35.68700 1.000 37.99554 ? 335 GLY   A O   1 
ATOM   984  N N   . ASN   A 1 140 ? 3.33500   -1.24600  -35.39500 1.000 40.42161 ? 336 ASN   A N   1 
ATOM   985  C CA  . ASN   A 1 140 ? 3.42600   -0.67300  -36.73300 1.000 40.61508 ? 336 ASN   A CA  1 
ATOM   986  C C   . ASN   A 1 140 ? 3.98500   -1.62800  -37.78600 1.000 47.52217 ? 336 ASN   A C   1 
ATOM   987  O O   . ASN   A 1 140 ? 3.96100   -1.27500  -38.96900 1.000 47.13533 ? 336 ASN   A O   1 
ATOM   988  C CB  . ASN   A 1 140 ? 4.29000   0.57800   -36.71200 1.000 36.29172 ? 336 ASN   A CB  1 
ATOM   989  C CG  . ASN   A 1 140 ? 3.72400   1.64600   -35.77300 1.000 41.17415 ? 336 ASN   A CG  1 
ATOM   990  O OD1 . ASN   A 1 140 ? 2.73600   2.31000   -36.09000 1.000 44.48537 ? 336 ASN   A OD1 1 
ATOM   991  N ND2 . ASN   A 1 140 ? 4.32500   1.77500   -34.60500 1.000 34.12270 ? 336 ASN   A ND2 1 
ATOM   992  N N   . GLY   A 1 141 ? 4.50900   -2.79600  -37.39100 1.000 39.15521 ? 337 GLY   A N   1 
ATOM   993  C CA  . GLY   A 1 141 ? 4.96600   -3.78500  -38.34200 1.000 38.01381 ? 337 GLY   A CA  1 
ATOM   994  C C   . GLY   A 1 141 ? 4.34900   -5.14400  -38.06400 1.000 41.55388 ? 337 GLY   A C   1 
ATOM   995  O O   . GLY   A 1 141 ? 3.91200   -5.44300  -36.95300 1.000 38.47430 ? 337 GLY   A O   1 
ATOM   996  N N   . PHE   A 1 142 ? 4.31100   -5.96800  -39.10500 1.000 38.81748 ? 338 PHE   A N   1 
ATOM   997  C CA  . PHE   A 1 142 ? 3.80600   -7.33800  -39.00200 1.000 36.15143 ? 338 PHE   A CA  1 
ATOM   998  C C   . PHE   A 1 142 ? 4.76300   -8.24100  -39.76900 1.000 39.24179 ? 338 PHE   A C   1 
ATOM   999  O O   . PHE   A 1 142 ? 4.86000   -8.15000  -40.99700 1.000 43.16401 ? 338 PHE   A O   1 
ATOM   1000 C CB  . PHE   A 1 142 ? 2.38400   -7.43100  -39.54600 1.000 40.01012 ? 338 PHE   A CB  1 
ATOM   1001 C CG  . PHE   A 1 142 ? 1.78200   -8.81300  -39.48700 1.000 43.38331 ? 338 PHE   A CG  1 
ATOM   1002 C CD1 . PHE   A 1 142 ? 1.19500   -9.28100  -38.31500 1.000 40.42971 ? 338 PHE   A CD1 1 
ATOM   1003 C CD2 . PHE   A 1 142 ? 1.78000   -9.63500  -40.60800 1.000 43.01501 ? 338 PHE   A CD2 1 
ATOM   1004 C CE1 . PHE   A 1 142 ? 0.61800   -10.55300 -38.26100 1.000 41.83072 ? 338 PHE   A CE1 1 
ATOM   1005 C CE2 . PHE   A 1 142 ? 1.21200   -10.90600 -40.56500 1.000 41.01887 ? 338 PHE   A CE2 1 
ATOM   1006 C CZ  . PHE   A 1 142 ? 0.62500   -11.36400 -39.39200 1.000 45.27781 ? 338 PHE   A CZ  1 
ATOM   1007 N N   . ILE   A 1 143 ? 5.51500   -9.06900  -39.06300 1.000 37.44538 ? 339 ILE   A N   1 
ATOM   1008 C CA  . ILE   A 1 143 ? 6.46600   -9.96800  -39.70700 1.000 45.20201 ? 339 ILE   A CA  1 
ATOM   1009 C C   . ILE   A 1 143 ? 5.82000   -11.34600 -39.82900 1.000 41.42848 ? 339 ILE   A C   1 
ATOM   1010 O O   . ILE   A 1 143 ? 5.21000   -11.83900 -38.87200 1.000 41.16270 ? 339 ILE   A O   1 
ATOM   1011 C CB  . ILE   A 1 143 ? 7.80400   -10.00200 -38.94700 1.000 43.63032 ? 339 ILE   A CB  1 
ATOM   1012 C CG1 . ILE   A 1 143 ? 8.82700   -10.84300 -39.70600 1.000 48.52473 ? 339 ILE   A CG1 1 
ATOM   1013 C CG2 . ILE   A 1 143 ? 7.63800   -10.51000 -37.53500 1.000 45.36213 ? 339 ILE   A CG2 1 
ATOM   1014 C CD1 . ILE   A 1 143 ? 10.24600  -10.42800 -39.42200 1.000 49.84559 ? 339 ILE   A CD1 1 
ATOM   1015 N N   . THR   A 1 144 ? 5.89800   -11.94000 -41.02700 1.000 43.38263 ? 340 THR   A N   1 
ATOM   1016 C CA  . THR   A 1 144 ? 5.13600   -13.15200 -41.32800 1.000 40.12672 ? 340 THR   A CA  1 
ATOM   1017 C C   . THR   A 1 144 ? 5.81900   -14.37100 -40.73600 1.000 38.76147 ? 340 THR   A C   1 
ATOM   1018 O O   . THR   A 1 144 ? 7.05000   -14.43600 -40.63900 1.000 37.87205 ? 340 THR   A O   1 
ATOM   1019 C CB  . THR   A 1 144 ? 4.96400   -13.37400 -42.84600 1.000 45.55591 ? 340 THR   A CB  1 
ATOM   1020 O OG1 . THR   A 1 144 ? 6.21800   -13.77900 -43.42600 1.000 42.59268 ? 340 THR   A OG1 1 
ATOM   1021 C CG2 . THR   A 1 144 ? 4.47400   -12.11400 -43.54200 1.000 44.68401 ? 340 THR   A CG2 1 
ATOM   1022 N N   . ARG   A 1 145 ? 4.99400   -15.35900 -40.37100 1.000 38.58948 ? 341 ARG   A N   1 
ATOM   1023 C CA  . ARG   A 1 145 ? 5.51100   -16.62700 -39.85900 1.000 43.33830 ? 341 ARG   A CA  1 
ATOM   1024 C C   . ARG   A 1 145 ? 6.41000   -17.32200 -40.88000 1.000 48.40233 ? 341 ARG   A C   1 
ATOM   1025 O O   . ARG   A 1 145 ? 7.48400   -17.84300 -40.53400 1.000 46.54161 ? 341 ARG   A O   1 
ATOM   1026 C CB  . ARG   A 1 145 ? 4.33500   -17.53000 -39.48900 1.000 41.80791 ? 341 ARG   A CB  1 
ATOM   1027 C CG  . ARG   A 1 145 ? 4.69800   -18.74400 -38.68500 1.000 44.16703 ? 341 ARG   A CG  1 
ATOM   1028 C CD  . ARG   A 1 145 ? 3.42000   -19.44900 -38.28600 1.000 42.54153 ? 341 ARG   A CD  1 
ATOM   1029 N NE  . ARG   A 1 145 ? 3.70100   -20.63400 -37.49800 1.000 43.71048 ? 341 ARG   A NE  1 
ATOM   1030 C CZ  . ARG   A 1 145 ? 2.76600   -21.36800 -36.92100 1.000 43.57988 ? 341 ARG   A CZ  1 
ATOM   1031 N NH1 . ARG   A 1 145 ? 1.48000   -21.05900 -37.02800 1.000 44.91102 ? 341 ARG   A NH1 1 
ATOM   1032 N NH2 . ARG   A 1 145 ? 3.12600   -22.43200 -36.21900 1.000 45.50094 ? 341 ARG   A NH2 1 
ATOM   1033 N N   . GLU   A 1 146 ? 5.98200   -17.34300 -42.14200 1.000 47.41526 ? 342 GLU   A N   1 
ATOM   1034 C CA  . GLU   A 1 146 ? 6.79200   -17.94700 -43.19600 1.000 48.31631 ? 342 GLU   A CA  1 
ATOM   1035 C C   . GLU   A 1 146 ? 8.14300   -17.25800 -43.33200 1.000 50.31295 ? 342 GLU   A C   1 
ATOM   1036 O O   . GLU   A 1 146 ? 9.17400   -17.93500 -43.46800 1.000 51.25892 ? 342 GLU   A O   1 
ATOM   1037 C CB  . GLU   A 1 146 ? 6.03600   -17.91400 -44.52300 1.000 49.11405 ? 342 GLU   A CB  1 
ATOM   1038 C CG  . GLU   A 1 146 ? 4.97400   -18.98400 -44.61900 1.000 57.79287 ? 342 GLU   A CG  1 
ATOM   1039 C CD  . GLU   A 1 146 ? 5.55300   -20.38200 -44.42200 1.000 62.15919 ? 342 GLU   A CD  1 
ATOM   1040 O OE1 . GLU   A 1 146 ? 4.97900   -21.16100 -43.62800 1.000 63.19490 ? 342 GLU   A OE1 1 
ATOM   1041 O OE2 . GLU   A 1 146 ? 6.60100   -20.68900 -45.04000 1.000 62.25899 ? 342 GLU   A OE2 1 
ATOM   1042 N N   . PHE   A 1 147 ? 8.17000   -15.91500 -43.27000 1.000 41.92768 ? 343 PHE   A N   1 
ATOM   1043 C CA  . PHE   A 1 147 ? 9.44900   -15.22200 -43.41800 1.000 45.74103 ? 343 PHE   A CA  1 
ATOM   1044 C C   . PHE   A 1 147 ? 10.41900  -15.61700 -42.31800 1.000 49.12150 ? 343 PHE   A C   1 
ATOM   1045 O O   . PHE   A 1 147 ? 11.59800  -15.86500 -42.58600 1.000 50.26548 ? 343 PHE   A O   1 
ATOM   1046 C CB  . PHE   A 1 147 ? 9.27000   -13.70300 -43.44100 1.000 45.94498 ? 343 PHE   A CB  1 
ATOM   1047 C CG  . PHE   A 1 147 ? 10.57500  -12.94700 -43.52600 1.000 49.13858 ? 343 PHE   A CG  1 
ATOM   1048 C CD1 . PHE   A 1 147 ? 11.47800  -13.19900 -44.55800 1.000 53.76585 ? 343 PHE   A CD1 1 
ATOM   1049 C CD2 . PHE   A 1 147 ? 10.91100  -12.00100 -42.57000 1.000 49.67268 ? 343 PHE   A CD2 1 
ATOM   1050 C CE1 . PHE   A 1 147 ? 12.69300  -12.51400 -44.63700 1.000 51.14874 ? 343 PHE   A CE1 1 
ATOM   1051 C CE2 . PHE   A 1 147 ? 12.11700  -11.31200 -42.64200 1.000 53.98434 ? 343 PHE   A CE2 1 
ATOM   1052 C CZ  . PHE   A 1 147 ? 13.01000  -11.56700 -43.68500 1.000 56.83347 ? 343 PHE   A CZ  1 
ATOM   1053 N N   . LEU   A 1 148 ? 9.94800   -15.67500 -41.06700 1.000 46.75453 ? 344 LEU   A N   1 
ATOM   1054 C CA  . LEU   A 1 148 ? 10.81000  -16.15600 -39.99300 1.000 49.39650 ? 344 LEU   A CA  1 
ATOM   1055 C C   . LEU   A 1 148 ? 11.25600  -17.59000 -40.26000 1.000 49.65907 ? 344 LEU   A C   1 
ATOM   1056 O O   . LEU   A 1 148 ? 12.42000  -17.93900 -40.03200 1.000 51.71233 ? 344 LEU   A O   1 
ATOM   1057 C CB  . LEU   A 1 148 ? 10.08400  -16.06300 -38.64400 1.000 39.49958 ? 344 LEU   A CB  1 
ATOM   1058 C CG  . LEU   A 1 148 ? 9.79300   -14.62800 -38.20800 1.000 41.43461 ? 344 LEU   A CG  1 
ATOM   1059 C CD1 . LEU   A 1 148 ? 8.62700   -14.59100 -37.24000 1.000 41.33469 ? 344 LEU   A CD1 1 
ATOM   1060 C CD2 . LEU   A 1 148 ? 11.04900  -14.04300 -37.60800 1.000 36.96548 ? 344 LEU   A CD2 1 
ATOM   1061 N N   . LYS   A 1 149 ? 10.33700  -18.43400 -40.73300 1.000 47.51680 ? 345 LYS   A N   1 
ATOM   1062 C CA  . LYS   A 1 149 ? 10.69300  -19.81100 -41.05900 1.000 56.46631 ? 345 LYS   A CA  1 
ATOM   1063 C C   . LYS   A 1 149 ? 11.76200  -19.87500 -42.14800 1.000 55.94000 ? 345 LYS   A C   1 
ATOM   1064 O O   . LYS   A 1 149 ? 12.51800  -20.84900 -42.21700 1.000 59.12233 ? 345 LYS   A O   1 
ATOM   1065 C CB  . LYS   A 1 149 ? 9.44400   -20.58300 -41.49000 1.000 55.09241 ? 345 LYS   A CB  1 
ATOM   1066 C CG  . LYS   A 1 149 ? 8.92200   -21.52000 -40.41700 1.000 59.26734 ? 345 LYS   A CG  1 
ATOM   1067 C CD  . LYS   A 1 149 ? 7.84700   -22.44700 -40.95900 1.000 60.71404 ? 345 LYS   A CD  1 
ATOM   1068 C CE  . LYS   A 1 149 ? 6.45800   -21.85000 -40.77900 1.000 58.67573 ? 345 LYS   A CE  1 
ATOM   1069 N NZ  . LYS   A 1 149 ? 5.42700   -22.93300 -40.69400 1.000 62.79528 ? 345 LYS   A NZ  1 
ATOM   1070 N N   . SER   A 1 150 ? 11.85500  -18.84200 -42.98700 1.000 54.25726 ? 346 SER   A N   1 
ATOM   1071 C CA  . SER   A 1 150 ? 12.77400  -18.85100 -44.12100 1.000 55.83189 ? 346 SER   A CA  1 
ATOM   1072 C C   . SER   A 1 150 ? 14.19100  -18.40200 -43.78100 1.000 58.47295 ? 346 SER   A C   1 
ATOM   1073 O O   . SER   A 1 150 ? 15.04900  -18.43000 -44.67000 1.000 56.59156 ? 346 SER   A O   1 
ATOM   1074 C CB  . SER   A 1 150 ? 12.24800  -17.94500 -45.22500 1.000 50.16574 ? 346 SER   A CB  1 
ATOM   1075 O OG  . SER   A 1 150 ? 12.73700  -16.62500 -45.03500 1.000 53.49236 ? 346 SER   A OG  1 
ATOM   1076 N N   . LEU   A 1 151 ? 14.46100  -17.96200 -42.55300 1.000 56.42195 ? 347 LEU   A N   1 
ATOM   1077 C CA  . LEU   A 1 151 ? 15.79300  -17.46400 -42.22600 1.000 53.93979 ? 347 LEU   A CA  1 
ATOM   1078 C C   . LEU   A 1 151 ? 16.77100  -18.63000 -42.07200 1.000 57.69503 ? 347 LEU   A C   1 
ATOM   1079 O O   . LEU   A 1 151 ? 16.39600  -19.80400 -42.08300 1.000 57.90217 ? 347 LEU   A O   1 
ATOM   1080 C CB  . LEU   A 1 151 ? 15.76600  -16.63100 -40.94100 1.000 54.89401 ? 347 LEU   A CB  1 
ATOM   1081 C CG  . LEU   A 1 151 ? 14.87700  -15.38100 -40.83800 1.000 53.22856 ? 347 LEU   A CG  1 
ATOM   1082 C CD1 . LEU   A 1 151 ? 14.70900  -14.95400 -39.35900 1.000 48.78291 ? 347 LEU   A CD1 1 
ATOM   1083 C CD2 . LEU   A 1 151 ? 15.41700  -14.23400 -41.67400 1.000 46.72899 ? 347 LEU   A CD2 1 
ATOM   1084 N N   . ARG   A 1 152 ? 18.04500  -18.30100 -41.91900 1.000 59.32113 ? 348 ARG   A N   1 
ATOM   1085 C CA  . ARG   A 1 152 ? 19.03600  -19.35200 -41.77100 1.000 62.78649 ? 348 ARG   A CA  1 
ATOM   1086 C C   . ARG   A 1 152 ? 19.10700  -19.79800 -40.31700 1.000 63.29623 ? 348 ARG   A C   1 
ATOM   1087 O O   . ARG   A 1 152 ? 18.83300  -19.02800 -39.39300 1.000 63.26059 ? 348 ARG   A O   1 
ATOM   1088 C CB  . ARG   A 1 152 ? 20.40200  -18.87300 -42.26500 1.000 60.96951 ? 348 ARG   A CB  1 
ATOM   1089 C CG  . ARG   A 1 152 ? 21.07700  -17.86300 -41.37200 1.000 60.15647 ? 348 ARG   A CG  1 
ATOM   1090 C CD  . ARG   A 1 152 ? 22.55900  -18.13400 -41.31000 1.000 61.13139 ? 348 ARG   A CD  1 
ATOM   1091 N NE  . ARG   A 1 152 ? 23.32000  -17.01000 -40.77700 1.000 56.28449 ? 348 ARG   A NE  1 
ATOM   1092 C CZ  . ARG   A 1 152 ? 23.79400  -16.96200 -39.54200 1.000 56.96083 ? 348 ARG   A CZ  1 
ATOM   1093 N NH1 . ARG   A 1 152 ? 23.55700  -17.93300 -38.67400 1.000 57.13979 ? 348 ARG   A NH1 1 
ATOM   1094 N NH2 . ARG   A 1 152 ? 24.51900  -15.91300 -39.16600 1.000 57.88401 ? 348 ARG   A NH2 1 
ATOM   1095 N N   . LYS   A 1 153 ? 19.44300  -21.06700 -40.11900 1.000 60.16547 ? 349 LYS   A N   1 
ATOM   1096 C CA  . LYS   A 1 153 ? 19.59100  -21.57400 -38.76700 1.000 59.72581 ? 349 LYS   A CA  1 
ATOM   1097 C C   . LYS   A 1 153 ? 20.63900  -20.75500 -38.01100 1.000 60.17829 ? 349 LYS   A C   1 
ATOM   1098 O O   . LYS   A 1 153 ? 21.54800  -20.17800 -38.61800 1.000 61.14774 ? 349 LYS   A O   1 
ATOM   1099 C CB  . LYS   A 1 153 ? 19.97500  -23.05300 -38.79700 1.000 66.60668 ? 349 LYS   A CB  1 
ATOM   1100 C CG  . LYS   A 1 153 ? 18.84000  -23.96100 -39.27900 1.000 63.83445 ? 349 LYS   A CG  1 
ATOM   1101 C CD  . LYS   A 1 153 ? 19.15600  -25.43300 -39.05200 1.000 67.85614 ? 349 LYS   A CD  1 
ATOM   1102 C CE  . LYS   A 1 153 ? 18.41800  -25.98300 -37.83900 1.000 69.32016 ? 349 LYS   A CE  1 
ATOM   1103 N NZ  . LYS   A 1 153 ? 16.95800  -26.18200 -38.11900 1.000 66.89922 ? 349 LYS   A NZ  1 
ATOM   1104 N N   . PRO   A 1 154 ? 20.50800  -20.63300 -36.67900 1.000 58.54539 ? 350 PRO   A N   1 
ATOM   1105 C CA  . PRO   A 1 154 ? 19.42700  -21.14900 -35.83700 1.000 56.68563 ? 350 PRO   A CA  1 
ATOM   1106 C C   . PRO   A 1 154 ? 18.22700  -20.20600 -35.74900 1.000 59.12744 ? 350 PRO   A C   1 
ATOM   1107 O O   . PRO   A 1 154 ? 17.30100  -20.46200 -34.97200 1.000 59.94576 ? 350 PRO   A O   1 
ATOM   1108 C CB  . PRO   A 1 154 ? 20.09000  -21.25700 -34.47100 1.000 59.24642 ? 350 PRO   A CB  1 
ATOM   1109 C CG  . PRO   A 1 154 ? 21.03600  -20.06900 -34.45000 1.000 55.05286 ? 350 PRO   A CG  1 
ATOM   1110 C CD  . PRO   A 1 154 ? 21.47800  -19.84900 -35.88800 1.000 61.97418 ? 350 PRO   A CD  1 
ATOM   1111 N N   . PHE   A 1 155 ? 18.24500  -19.11800 -36.52100 1.000 56.76174 ? 351 PHE   A N   1 
ATOM   1112 C CA  . PHE   A 1 155 ? 17.26500  -18.06000 -36.30300 1.000 55.11042 ? 351 PHE   A CA  1 
ATOM   1113 C C   . PHE   A 1 155 ? 15.86100  -18.52500 -36.65100 1.000 56.41326 ? 351 PHE   A C   1 
ATOM   1114 O O   . PHE   A 1 155 ? 14.91000  -18.24000 -35.91500 1.000 55.10148 ? 351 PHE   A O   1 
ATOM   1115 C CB  . PHE   A 1 155 ? 17.66700  -16.81500 -37.08600 1.000 50.46204 ? 351 PHE   A CB  1 
ATOM   1116 C CG  . PHE   A 1 155 ? 18.93100  -16.20200 -36.57700 1.000 55.96628 ? 351 PHE   A CG  1 
ATOM   1117 C CD1 . PHE   A 1 155 ? 18.92600  -15.45000 -35.41500 1.000 53.70355 ? 351 PHE   A CD1 1 
ATOM   1118 C CD2 . PHE   A 1 155 ? 20.13800  -16.43100 -37.22100 1.000 56.99714 ? 351 PHE   A CD2 1 
ATOM   1119 C CE1 . PHE   A 1 155 ? 20.09500  -14.90200 -34.91400 1.000 55.43778 ? 351 PHE   A CE1 1 
ATOM   1120 C CE2 . PHE   A 1 155 ? 21.31100  -15.88700 -36.73300 1.000 55.13952 ? 351 PHE   A CE2 1 
ATOM   1121 C CZ  . PHE   A 1 155 ? 21.29400  -15.11800 -35.57800 1.000 59.63714 ? 351 PHE   A CZ  1 
ATOM   1122 N N   . CYS   A 1 156 ? 15.71600  -19.28200 -37.73900 1.000 55.58612 ? 352 CYS   A N   1 
ATOM   1123 C CA  . CYS   A 1 156 ? 14.41700  -19.81400 -38.12900 1.000 54.23521 ? 352 CYS   A CA  1 
ATOM   1124 C C   . CYS   A 1 156 ? 13.83200  -20.76700 -37.09600 1.000 50.18591 ? 352 CYS   A C   1 
ATOM   1125 O O   . CYS   A 1 156 ? 12.65700  -21.13000 -37.20900 1.000 51.62921 ? 352 CYS   A O   1 
ATOM   1126 C CB  . CYS   A 1 156 ? 14.54500  -20.53900 -39.46500 1.000 58.05867 ? 352 CYS   A CB  1 
ATOM   1127 S SG  . CYS   A 1 156 ? 15.70800  -21.92700 -39.34700 1.000 61.76370 ? 352 CYS   A SG  1 
ATOM   1128 N N   . ASP   A 1 157 ? 14.61800  -21.19100 -36.11100 1.000 52.67987 ? 353 ASP   A N   1 
ATOM   1129 C CA  . ASP   A 1 157 ? 14.17200  -22.09200 -35.06100 1.000 55.76989 ? 353 ASP   A CA  1 
ATOM   1130 C C   . ASP   A 1 157 ? 13.59500  -21.37400 -33.83700 1.000 54.82790 ? 353 ASP   A C   1 
ATOM   1131 O O   . ASP   A 1 157 ? 13.09100  -22.04200 -32.93300 1.000 53.33189 ? 353 ASP   A O   1 
ATOM   1132 C CB  . ASP   A 1 157 ? 15.33600  -22.97700 -34.60200 1.000 57.76550 ? 353 ASP   A CB  1 
ATOM   1133 C CG  . ASP   A 1 157 ? 15.78700  -23.97100 -35.66600 1.000 65.40695 ? 353 ASP   A CG  1 
ATOM   1134 O OD1 . ASP   A 1 157 ? 14.98900  -24.30800 -36.57600 1.000 61.21549 ? 353 ASP   A OD1 1 
ATOM   1135 O OD2 . ASP   A 1 157 ? 16.95000  -24.41800 -35.57500 1.000 69.03037 ? 353 ASP   A OD2 1 
ATOM   1136 N N   . ILE   A 1 158 ? 13.66200  -20.04600 -33.76400 1.000 54.22399 ? 354 ILE   A N   1 
ATOM   1137 C CA  . ILE   A 1 158 ? 13.35800  -19.37200 -32.50300 1.000 53.03188 ? 354 ILE   A CA  1 
ATOM   1138 C C   . ILE   A 1 158 ? 11.85600  -19.19200 -32.32200 1.000 49.94791 ? 354 ILE   A C   1 
ATOM   1139 O O   . ILE   A 1 158 ? 11.27500  -19.66500 -31.34100 1.000 45.87539 ? 354 ILE   A O   1 
ATOM   1140 C CB  . ILE   A 1 158 ? 14.09700  -18.03100 -32.41500 1.000 51.85229 ? 354 ILE   A CB  1 
ATOM   1141 C CG1 . ILE   A 1 158 ? 15.58400  -18.25000 -32.71300 1.000 49.47207 ? 354 ILE   A CG1 1 
ATOM   1142 C CG2 . ILE   A 1 158 ? 13.89800  -17.43200 -31.03400 1.000 47.42924 ? 354 ILE   A CG2 1 
ATOM   1143 C CD1 . ILE   A 1 158 ? 16.48800  -17.17600 -32.17700 1.000 52.11677 ? 354 ILE   A CD1 1 
ATOM   1144 N N   . MET   A 1 159 ? 11.20400  -18.52600 -33.27100 1.000 46.53708 ? 355 MET   A N   1 
ATOM   1145 C CA  . MET   A 1 159 ? 9.81200   -18.14700 -33.05900 1.000 47.87413 ? 355 MET   A CA  1 
ATOM   1146 C C   . MET   A 1 159 ? 8.83000   -19.28300 -33.29000 1.000 45.84310 ? 355 MET   A C   1 
ATOM   1147 O O   . MET   A 1 159 ? 7.73100   -19.24300 -32.73100 1.000 44.01958 ? 355 MET   A O   1 
ATOM   1148 C CB  . MET   A 1 159 ? 9.43800   -16.95300 -33.94700 1.000 41.99352 ? 355 MET   A CB  1 
ATOM   1149 C CG  . MET   A 1 159 ? 9.87900   -15.63500 -33.33900 1.000 46.10214 ? 355 MET   A CG  1 
ATOM   1150 S SD  . MET   A 1 159 ? 9.01100   -15.20800 -31.79800 1.000 46.82391 ? 355 MET   A SD  1 
ATOM   1151 C CE  . MET   A 1 159 ? 10.37300  -15.42000 -30.64900 1.000 44.63926 ? 355 MET   A CE  1 
ATOM   1152 N N   . GLU   A 1 160 ? 9.19100   -20.30600 -34.06700 1.000 47.73722 ? 356 GLU   A N   1 
ATOM   1153 C CA  . GLU   A 1 160 ? 8.19100   -21.30100 -34.46000 1.000 44.13947 ? 356 GLU   A CA  1 
ATOM   1154 C C   . GLU   A 1 160 ? 7.50400   -22.00900 -33.29900 1.000 42.39671 ? 356 GLU   A C   1 
ATOM   1155 O O   . GLU   A 1 160 ? 6.26300   -22.15000 -33.34800 1.000 41.86671 ? 356 GLU   A O   1 
ATOM   1156 C CB  . GLU   A 1 160 ? 8.81600   -22.32200 -35.41500 1.000 47.01688 ? 356 GLU   A CB  1 
ATOM   1157 C CG  . GLU   A 1 160 ? 7.79400   -23.32100 -35.93400 1.000 45.19927 ? 356 GLU   A CG  1 
ATOM   1158 C CD  . GLU   A 1 160 ? 6.63600   -22.67300 -36.69400 1.000 53.34557 ? 356 GLU   A CD  1 
ATOM   1159 O OE1 . GLU   A 1 160 ? 6.74700   -21.49900 -37.14000 1.000 49.73467 ? 356 GLU   A OE1 1 
ATOM   1160 O OE2 . GLU   A 1 160 ? 5.61000   -23.36200 -36.87900 1.000 56.96493 ? 356 GLU   A OE2 1 
ATOM   1161 N N   . PRO   A 1 161 ? 8.18500   -22.52000 -32.27200 1.000 40.75219 ? 357 PRO   A N   1 
ATOM   1162 C CA  . PRO   A 1 161 ? 7.44400   -23.10300 -31.14100 1.000 43.40140 ? 357 PRO   A CA  1 
ATOM   1163 C C   . PRO   A 1 161 ? 6.61700   -22.06600 -30.36600 1.000 45.62287 ? 357 PRO   A C   1 
ATOM   1164 O O   . PRO   A 1 161 ? 5.62700   -22.44100 -29.71100 1.000 38.48994 ? 357 PRO   A O   1 
ATOM   1165 C CB  . PRO   A 1 161 ? 8.54500   -23.72100 -30.26700 1.000 46.75537 ? 357 PRO   A CB  1 
ATOM   1166 C CG  . PRO   A 1 161 ? 9.75500   -22.91700 -30.58000 1.000 45.07181 ? 357 PRO   A CG  1 
ATOM   1167 C CD  . PRO   A 1 161 ? 9.64400   -22.53100 -32.03200 1.000 42.78601 ? 357 PRO   A CD  1 
ATOM   1168 N N   . LYS   A 1 162 ? 6.97600   -20.77900 -30.44200 1.000 40.76209 ? 358 LYS   A N   1 
ATOM   1169 C CA  . LYS   A 1 162 ? 6.16600   -19.75000 -29.78100 1.000 41.71387 ? 358 LYS   A CA  1 
ATOM   1170 C C   . LYS   A 1 162 ? 4.83600   -19.58300 -30.49600 1.000 40.76003 ? 358 LYS   A C   1 
ATOM   1171 O O   . LYS   A 1 162 ? 3.78700   -19.49300 -29.84200 1.000 36.10287 ? 358 LYS   A O   1 
ATOM   1172 C CB  . LYS   A 1 162 ? 6.91900   -18.41400 -29.71800 1.000 38.16553 ? 358 LYS   A CB  1 
ATOM   1173 C CG  . LYS   A 1 162 ? 7.94600   -18.33200 -28.59800 1.000 36.72171 ? 358 LYS   A CG  1 
ATOM   1174 C CD  . LYS   A 1 162 ? 9.07400   -19.33500 -28.80900 1.000 44.11038 ? 358 LYS   A CD  1 
ATOM   1175 C CE  . LYS   A 1 162 ? 10.32400  -19.03500 -27.99200 1.000 41.62214 ? 358 LYS   A CE  1 
ATOM   1176 N NZ  . LYS   A 1 162 ? 11.46300  -19.89600 -28.49400 1.000 44.45483 ? 358 LYS   A NZ  1 
ATOM   1177 N N   . PHE   A 1 163 ? 4.86600   -19.54800 -31.84200 1.000 39.16245 ? 359 PHE   A N   1 
ATOM   1178 C CA  . PHE   A 1 163 ? 3.64000   -19.60800 -32.63800 1.000 38.21899 ? 359 PHE   A CA  1 
ATOM   1179 C C   . PHE   A 1 163 ? 2.78900   -20.82500 -32.26200 1.000 42.19182 ? 359 PHE   A C   1 
ATOM   1180 O O   . PHE   A 1 163 ? 1.56300   -20.72200 -32.11800 1.000 41.06793 ? 359 PHE   A O   1 
ATOM   1181 C CB  . PHE   A 1 163 ? 3.96600   -19.64900 -34.14100 1.000 39.07772 ? 359 PHE   A CB  1 
ATOM   1182 C CG  . PHE   A 1 163 ? 4.23700   -18.29100 -34.74800 1.000 37.40969 ? 359 PHE   A CG  1 
ATOM   1183 C CD1 . PHE   A 1 163 ? 3.19800   -17.38600 -34.97200 1.000 37.24373 ? 359 PHE   A CD1 1 
ATOM   1184 C CD2 . PHE   A 1 163 ? 5.52500   -17.91600 -35.08400 1.000 39.32994 ? 359 PHE   A CD2 1 
ATOM   1185 C CE1 . PHE   A 1 163 ? 3.44900   -16.12600 -35.51800 1.000 39.52020 ? 359 PHE   A CE1 1 
ATOM   1186 C CE2 . PHE   A 1 163 ? 5.78500   -16.67000 -35.63300 1.000 36.87022 ? 359 PHE   A CE2 1 
ATOM   1187 C CZ  . PHE   A 1 163 ? 4.75000   -15.77000 -35.83800 1.000 38.61779 ? 359 PHE   A CZ  1 
ATOM   1188 N N   . ASP   A 1 164 ? 3.41600   -21.99600 -32.12800 1.000 40.12201 ? 360 ASP   A N   1 
ATOM   1189 C CA  . ASP   A 1 164 ? 2.64300   -23.18800 -31.78600 1.000 41.77544 ? 360 ASP   A CA  1 
ATOM   1190 C C   . ASP   A 1 164 ? 1.96500   -23.02300 -30.43100 1.000 42.17151 ? 360 ASP   A C   1 
ATOM   1191 O O   . ASP   A 1 164 ? 0.76700   -23.29500 -30.29100 1.000 40.23116 ? 360 ASP   A O   1 
ATOM   1192 C CB  . ASP   A 1 164 ? 3.52600   -24.44100 -31.79600 1.000 42.80946 ? 360 ASP   A CB  1 
ATOM   1193 C CG  . ASP   A 1 164 ? 3.86300   -24.91300 -33.20900 1.000 52.63783 ? 360 ASP   A CG  1 
ATOM   1194 O OD1 . ASP   A 1 164 ? 2.93800   -25.03500 -34.05000 1.000 54.05081 ? 360 ASP   A OD1 1 
ATOM   1195 O OD2 . ASP   A 1 164 ? 5.05500   -25.18000 -33.47400 1.000 57.28209 ? 360 ASP   A OD2 1 
ATOM   1196 N N   . PHE   A 1 165 ? 2.71400   -22.55200 -29.42500 1.000 39.54944 ? 361 PHE   A N   1 
ATOM   1197 C CA  . PHE   A 1 165 ? 2.10200   -22.28600 -28.12200 1.000 37.40288 ? 361 PHE   A CA  1 
ATOM   1198 C C   . PHE   A 1 165 ? 0.97600   -21.27200 -28.25200 1.000 39.90298 ? 361 PHE   A C   1 
ATOM   1199 O O   . PHE   A 1 165 ? -0.11000  -21.45600 -27.68100 1.000 39.85265 ? 361 PHE   A O   1 
ATOM   1200 C CB  . PHE   A 1 165 ? 3.15400   -21.79400 -27.12600 1.000 37.62400 ? 361 PHE   A CB  1 
ATOM   1201 C CG  . PHE   A 1 165 ? 2.57800   -21.40200 -25.77100 1.000 40.00210 ? 361 PHE   A CG  1 
ATOM   1202 C CD1 . PHE   A 1 165 ? 2.54400   -22.31300 -24.72600 1.000 37.20142 ? 361 PHE   A CD1 1 
ATOM   1203 C CD2 . PHE   A 1 165 ? 2.05200   -20.14200 -25.56300 1.000 37.76319 ? 361 PHE   A CD2 1 
ATOM   1204 C CE1 . PHE   A 1 165 ? 2.01200   -21.96200 -23.49100 1.000 38.47128 ? 361 PHE   A CE1 1 
ATOM   1205 C CE2 . PHE   A 1 165 ? 1.50500   -19.78300 -24.32900 1.000 33.67122 ? 361 PHE   A CE2 1 
ATOM   1206 C CZ  . PHE   A 1 165 ? 1.48600   -20.69100 -23.29800 1.000 37.02046 ? 361 PHE   A CZ  1 
ATOM   1207 N N   . ALA   A 1 166 ? 1.20900   -20.19900 -29.01000 1.000 39.04156 ? 362 ALA   A N   1 
ATOM   1208 C CA  . ALA   A 1 166 ? 0.24100   -19.11100 -29.06400 1.000 37.90535 ? 362 ALA   A CA  1 
ATOM   1209 C C   . ALA   A 1 166 ? -1.06800  -19.56400 -29.68600 1.000 39.91890 ? 362 ALA   A C   1 
ATOM   1210 O O   . ALA   A 1 166 ? -2.14300  -19.12900 -29.26100 1.000 40.24739 ? 362 ALA   A O   1 
ATOM   1211 C CB  . ALA   A 1 166 ? 0.81300   -17.92500 -29.84700 1.000 37.85628 ? 362 ALA   A CB  1 
ATOM   1212 N N   . MET   A 1 167 ? -1.00700  -20.43400 -30.70100 1.000 39.38826 ? 363 MET   A N   1 
ATOM   1213 C CA  . MET   A 1 167 ? -2.24500  -20.86800 -31.35200 1.000 41.73243 ? 363 MET   A CA  1 
ATOM   1214 C C   . MET   A 1 167 ? -3.17400  -21.58600 -30.37300 1.000 40.45623 ? 363 MET   A C   1 
ATOM   1215 O O   . MET   A 1 167 ? -4.38500  -21.32300 -30.34900 1.000 44.47918 ? 363 MET   A O   1 
ATOM   1216 C CB  . MET   A 1 167 ? -1.92100  -21.75000 -32.56100 1.000 41.06895 ? 363 MET   A CB  1 
ATOM   1217 C CG  . MET   A 1 167 ? -1.35500  -20.94800 -33.74800 1.000 42.96402 ? 363 MET   A CG  1 
ATOM   1218 S SD  . MET   A 1 167 ? -2.26900  -19.44400 -34.15900 1.000 50.94383 ? 363 MET   A SD  1 
ATOM   1219 C CE  . MET   A 1 167 ? -1.32800  -18.17600 -33.27400 1.000 44.02427 ? 363 MET   A CE  1 
ATOM   1220 N N   . LYS   A 1 168 ? -2.62900  -22.47700 -29.54500 1.000 37.54386 ? 364 LYS   A N   1 
ATOM   1221 C CA  . LYS   A 1 168 ? -3.45900  -23.14800 -28.54600 1.000 44.15126 ? 364 LYS   A CA  1 
ATOM   1222 C C   . LYS   A 1 168 ? -3.82900  -22.19900 -27.41200 1.000 41.24842 ? 364 LYS   A C   1 
ATOM   1223 O O   . LYS   A 1 168 ? -4.98900  -22.14900 -26.98800 1.000 45.19840 ? 364 LYS   A O   1 
ATOM   1224 C CB  . LYS   A 1 168 ? -2.74400  -24.38900 -28.00100 1.000 40.78372 ? 364 LYS   A CB  1 
ATOM   1225 C CG  . LYS   A 1 168 ? -2.68200  -25.51500 -29.02100 1.000 48.03193 ? 364 LYS   A CG  1 
ATOM   1226 C CD  . LYS   A 1 168 ? -1.72900  -26.63200 -28.59000 1.000 57.36045 ? 364 LYS   A CD  1 
ATOM   1227 C CE  . LYS   A 1 168 ? -0.27600  -26.15500 -28.50100 1.000 51.51696 ? 364 LYS   A CE  1 
ATOM   1228 N NZ  . LYS   A 1 168 ? 0.68300   -27.30500 -28.63200 1.000 57.96241 ? 364 LYS   A NZ  1 
ATOM   1229 N N   . PHE   A 1 169 ? -2.86100  -21.42600 -26.91500 1.000 38.31777 ? 365 PHE   A N   1 
ATOM   1230 C CA  . PHE   A 1 169 ? -3.17100  -20.47600 -25.84600 1.000 39.62381 ? 365 PHE   A CA  1 
ATOM   1231 C C   . PHE   A 1 169 ? -4.26400  -19.50400 -26.28200 1.000 35.68982 ? 365 PHE   A C   1 
ATOM   1232 O O   . PHE   A 1 169 ? -5.20500  -19.23500 -25.52600 1.000 39.38581 ? 365 PHE   A O   1 
ATOM   1233 C CB  . PHE   A 1 169 ? -1.89600  -19.73800 -25.42900 1.000 34.76570 ? 365 PHE   A CB  1 
ATOM   1234 C CG  . PHE   A 1 169 ? -2.02900  -18.92300 -24.15300 1.000 35.35635 ? 365 PHE   A CG  1 
ATOM   1235 C CD1 . PHE   A 1 169 ? -1.90600  -19.53100 -22.90300 1.000 37.35368 ? 365 PHE   A CD1 1 
ATOM   1236 C CD2 . PHE   A 1 169 ? -2.24900  -17.55600 -24.20100 1.000 36.14343 ? 365 PHE   A CD2 1 
ATOM   1237 C CE1 . PHE   A 1 169 ? -2.00000  -18.79600 -21.73200 1.000 38.60165 ? 365 PHE   A CE1 1 
ATOM   1238 C CE2 . PHE   A 1 169 ? -2.35100  -16.80300 -22.99700 1.000 31.25637 ? 365 PHE   A CE2 1 
ATOM   1239 C CZ  . PHE   A 1 169 ? -2.23300  -17.42100 -21.78600 1.000 34.87165 ? 365 PHE   A CZ  1 
ATOM   1240 N N   . ASN   A 1 170 ? -4.18500  -19.01000 -27.52300 1.000 38.11588 ? 366 ASN   A N   1 
ATOM   1241 C CA  . ASN   A 1 170 ? -5.18700  -18.07000 -28.02200 1.000 36.77303 ? 366 ASN   A CA  1 
ATOM   1242 C C   . ASN   A 1 170 ? -6.53700  -18.72900 -28.23100 1.000 40.53354 ? 366 ASN   A C   1 
ATOM   1243 O O   . ASN   A 1 170 ? -7.56700  -18.04200 -28.20200 1.000 42.70617 ? 366 ASN   A O   1 
ATOM   1244 C CB  . ASN   A 1 170 ? -4.72900  -17.43600 -29.33300 1.000 41.18031 ? 366 ASN   A CB  1 
ATOM   1245 C CG  . ASN   A 1 170 ? -3.63800  -16.42400 -29.11600 1.000 41.25731 ? 366 ASN   A CG  1 
ATOM   1246 O OD1 . ASN   A 1 170 ? -3.42600  -15.97500 -27.99000 1.000 40.49738 ? 366 ASN   A OD1 1 
ATOM   1247 N ND2 . ASN   A 1 170 ? -2.93400  -16.06900 -30.17500 1.000 34.84241 ? 366 ASN   A ND2 1 
ATOM   1248 N N   . ALA   A 1 171 ? -6.55200  -20.04400 -28.47700 1.000 41.98317 ? 367 ALA   A N   1 
ATOM   1249 C CA  . ALA   A 1 171 ? -7.81100  -20.77000 -28.61000 1.000 44.22800 ? 367 ALA   A CA  1 
ATOM   1250 C C   . ALA   A 1 171 ? -8.60700  -20.78800 -27.30700 1.000 48.29438 ? 367 ALA   A C   1 
ATOM   1251 O O   . ALA   A 1 171 ? -9.82300  -21.00400 -27.34600 1.000 53.54285 ? 367 ALA   A O   1 
ATOM   1252 C CB  . ALA   A 1 171 ? -7.54700  -22.20100 -29.10000 1.000 45.30180 ? 367 ALA   A CB  1 
ATOM   1253 N N   . LEU   A 1 172 ? -7.95900  -20.55200 -26.15800 1.000 46.46171 ? 368 LEU   A N   1 
ATOM   1254 C CA  . LEU   A 1 172 ? -8.68900  -20.40500 -24.89700 1.000 42.51103 ? 368 LEU   A CA  1 
ATOM   1255 C C   . LEU   A 1 172 ? -9.49100  -19.11400 -24.82200 1.000 42.59821 ? 368 LEU   A C   1 
ATOM   1256 O O   . LEU   A 1 172 ? -10.35600 -18.99400 -23.95600 1.000 43.64881 ? 368 LEU   A O   1 
ATOM   1257 C CB  . LEU   A 1 172 ? -7.73000  -20.46300 -23.71700 1.000 40.91010 ? 368 LEU   A CB  1 
ATOM   1258 C CG  . LEU   A 1 172 ? -6.78900  -21.66200 -23.65700 1.000 46.95695 ? 368 LEU   A CG  1 
ATOM   1259 C CD1 . LEU   A 1 172 ? -5.98600  -21.59700 -22.38000 1.000 40.35852 ? 368 LEU   A CD1 1 
ATOM   1260 C CD2 . LEU   A 1 172 ? -7.61100  -22.96400 -23.69700 1.000 47.53381 ? 368 LEU   A CD2 1 
ATOM   1261 N N   . GLU   A 1 173 ? -9.18900  -18.13600 -25.67100 1.000 46.34285 ? 369 GLU   A N   1 
ATOM   1262 C CA  . GLU   A 1 173 ? -9.94300  -16.88400 -25.75000 1.000 47.62129 ? 369 GLU   A CA  1 
ATOM   1263 C C   . GLU   A 1 173 ? -9.88100  -16.09500 -24.44400 1.000 42.93185 ? 369 GLU   A C   1 
ATOM   1264 O O   . GLU   A 1 173 ? -10.87700 -15.54300 -23.98500 1.000 42.99429 ? 369 GLU   A O   1 
ATOM   1265 C CB  . GLU   A 1 173 ? -11.39700 -17.13900 -26.16400 1.000 50.76973 ? 369 GLU   A CB  1 
ATOM   1266 C CG  . GLU   A 1 173 ? -11.54600 -17.42500 -27.65300 1.000 56.90664 ? 369 GLU   A CG  1 
ATOM   1267 C CD  . GLU   A 1 173 ? -12.99100 -17.60800 -28.07600 1.000 70.06378 ? 369 GLU   A CD  1 
ATOM   1268 O OE1 . GLU   A 1 173 ? -13.60600 -18.62500 -27.68100 1.000 62.38566 ? 369 GLU   A OE1 1 
ATOM   1269 O OE2 . GLU   A 1 173 ? -13.51000 -16.73400 -28.81300 1.000 76.83755 ? 369 GLU   A OE2 1 
ATOM   1270 N N   . LEU   A 1 174 ? -8.69900  -16.01400 -23.84400 1.000 42.07806 ? 370 LEU   A N   1 
ATOM   1271 C CA  . LEU   A 1 174 ? -8.55700  -15.14300 -22.68700 1.000 39.60218 ? 370 LEU   A CA  1 
ATOM   1272 C C   . LEU   A 1 174 ? -8.60400  -13.68600 -23.12600 1.000 38.64313 ? 370 LEU   A C   1 
ATOM   1273 O O   . LEU   A 1 174 ? -8.26600  -13.34500 -24.26000 1.000 37.94801 ? 370 LEU   A O   1 
ATOM   1274 C CB  . LEU   A 1 174 ? -7.24200  -15.41000 -21.96500 1.000 38.06000 ? 370 LEU   A CB  1 
ATOM   1275 C CG  . LEU   A 1 174 ? -6.88900  -16.83300 -21.54700 1.000 40.26542 ? 370 LEU   A CG  1 
ATOM   1276 C CD1 . LEU   A 1 174 ? -5.64000  -16.80100 -20.66400 1.000 36.78053 ? 370 LEU   A CD1 1 
ATOM   1277 C CD2 . LEU   A 1 174 ? -8.07200  -17.45300 -20.80700 1.000 40.26708 ? 370 LEU   A CD2 1 
ATOM   1278 N N   . ASP   A 1 175 ? -9.03500  -12.83000 -22.22400 1.000 39.24460 ? 371 ASP   A N   1 
ATOM   1279 C CA  . ASP   A 1 175 ? -8.88300  -11.39800 -22.41000 1.000 42.11205 ? 371 ASP   A CA  1 
ATOM   1280 C C   . ASP   A 1 175 ? -7.84500  -10.87600 -21.41500 1.000 38.70371 ? 371 ASP   A C   1 
ATOM   1281 O O   . ASP   A 1 175 ? -7.29100  -11.62700 -20.59400 1.000 33.28873 ? 371 ASP   A O   1 
ATOM   1282 C CB  . ASP   A 1 175 ? -10.22700 -10.66500 -22.27500 1.000 39.98814 ? 371 ASP   A CB  1 
ATOM   1283 C CG  . ASP   A 1 175 ? -10.89700 -10.86000 -20.92200 1.000 44.42921 ? 371 ASP   A CG  1 
ATOM   1284 O OD1 . ASP   A 1 175 ? -10.21200 -10.82900 -19.87600 1.000 42.98262 ? 371 ASP   A OD1 1 
ATOM   1285 O OD2 . ASP   A 1 175 ? -12.15000 -10.99800 -20.90400 1.000 48.90834 ? 371 ASP   A OD2 1 
ATOM   1286 N N   . ASP   A 1 176 ? -7.60500  -9.56500  -21.49100 1.000 34.48042 ? 372 ASP   A N   1 
ATOM   1287 C CA  . ASP   A 1 176 ? -6.54600  -8.93800  -20.70800 1.000 32.29662 ? 372 ASP   A CA  1 
ATOM   1288 C C   . ASP   A 1 176 ? -6.76500  -9.10400  -19.21600 1.000 34.43790 ? 372 ASP   A C   1 
ATOM   1289 O O   . ASP   A 1 176 ? -5.79500  -9.21700  -18.45300 1.000 35.27647 ? 372 ASP   A O   1 
ATOM   1290 C CB  . ASP   A 1 176 ? -6.44900  -7.45600  -21.06600 1.000 33.92118 ? 372 ASP   A CB  1 
ATOM   1291 C CG  . ASP   A 1 176 ? -5.87800  -7.23200  -22.46100 1.000 41.45529 ? 372 ASP   A CG  1 
ATOM   1292 O OD1 . ASP   A 1 176 ? -4.76600  -7.75200  -22.73900 1.000 39.43588 ? 372 ASP   A OD1 1 
ATOM   1293 O OD2 . ASP   A 1 176 ? -6.55400  -6.56100  -23.28100 1.000 41.37721 ? 372 ASP   A OD2 1 
ATOM   1294 N N   . SER   A 1 177 ? -8.02100  -9.06000  -18.75800 1.000 33.91775 ? 373 SER   A N   1 
ATOM   1295 C CA  . SER   A 1 177 ? -8.23500  -9.22500  -17.32100 1.000 35.64317 ? 373 SER   A CA  1 
ATOM   1296 C C   . SER   A 1 177 ? -7.78300  -10.61200 -16.86300 1.000 33.37238 ? 373 SER   A C   1 
ATOM   1297 O O   . SER   A 1 177 ? -7.15200  -10.73900 -15.80800 1.000 35.96455 ? 373 SER   A O   1 
ATOM   1298 C CB  . SER   A 1 177 ? -9.69900  -8.97000  -16.95000 1.000 34.38058 ? 373 SER   A CB  1 
ATOM   1299 O OG  . SER   A 1 177 ? -10.54400 -9.93000  -17.56000 1.000 42.93288 ? 373 SER   A OG  1 
ATOM   1300 N N   . ASP   A 1 178 ? -8.05000  -11.65600 -17.65900 1.000 33.63301 ? 374 ASP   A N   1 
ATOM   1301 C CA  . ASP   A 1 178 ? -7.53700  -12.98500 -17.30400 1.000 34.68180 ? 374 ASP   A CA  1 
ATOM   1302 C C   . ASP   A 1 178 ? -6.01500  -13.03300 -17.42700 1.000 33.45375 ? 374 ASP   A C   1 
ATOM   1303 O O   . ASP   A 1 178 ? -5.33300  -13.59300 -16.56400 1.000 31.05513 ? 374 ASP   A O   1 
ATOM   1304 C CB  . ASP   A 1 178 ? -8.10300  -14.08700 -18.20600 1.000 32.64592 ? 374 ASP   A CB  1 
ATOM   1305 C CG  . ASP   A 1 178 ? -9.60200  -14.00400 -18.41300 1.000 40.44517 ? 374 ASP   A CG  1 
ATOM   1306 O OD1 . ASP   A 1 178 ? -10.35300 -13.86300 -17.42300 1.000 38.41787 ? 374 ASP   A OD1 1 
ATOM   1307 O OD2 . ASP   A 1 178 ? -10.02700 -14.11600 -19.59000 1.000 40.09082 ? 374 ASP   A OD2 1 
ATOM   1308 N N   . ILE   A 1 179 ? -5.47400  -12.48200 -18.51900 1.000 30.98448 ? 375 ILE   A N   1 
ATOM   1309 C CA  . ILE   A 1 179 ? -4.03100  -12.55700 -18.76500 1.000 34.13190 ? 375 ILE   A CA  1 
ATOM   1310 C C   . ILE   A 1 179 ? -3.26700  -11.83800 -17.66500 1.000 30.22085 ? 375 ILE   A C   1 
ATOM   1311 O O   . ILE   A 1 179 ? -2.19500  -12.29000 -17.23900 1.000 28.78939 ? 375 ILE   A O   1 
ATOM   1312 C CB  . ILE   A 1 179 ? -3.69000  -12.01000 -20.17100 1.000 31.46997 ? 375 ILE   A CB  1 
ATOM   1313 C CG1 . ILE   A 1 179 ? -4.17900  -12.97400 -21.23900 1.000 30.95954 ? 375 ILE   A CG1 1 
ATOM   1314 C CG2 . ILE   A 1 179 ? -2.18300  -11.82000 -20.38700 1.000 27.60121 ? 375 ILE   A CG2 1 
ATOM   1315 C CD1 . ILE   A 1 179 ? -4.40800  -12.31200 -22.61900 1.000 30.60981 ? 375 ILE   A CD1 1 
ATOM   1316 N N   . SER   A 1 180 ? -3.82400  -10.73700 -17.14000 1.000 29.41742 ? 376 SER   A N   1 
ATOM   1317 C CA  . SER   A 1 180 ? -3.11800  -10.01000 -16.09600 1.000 29.30359 ? 376 SER   A CA  1 
ATOM   1318 C C   . SER   A 1 180 ? -2.94000  -10.87300 -14.85000 1.000 30.94930 ? 376 SER   A C   1 
ATOM   1319 O O   . SER   A 1 180 ? -1.88700  -10.82400 -14.20600 1.000 30.08838 ? 376 SER   A O   1 
ATOM   1320 C CB  . SER   A 1 180 ? -3.85000  -8.70800  -15.74300 1.000 33.61460 ? 376 SER   A CB  1 
ATOM   1321 O OG  . SER   A 1 180 ? -5.12000  -8.97900  -15.15700 1.000 31.63082 ? 376 SER   A OG  1 
ATOM   1322 N N   . LEU   A 1 181 ? -3.95800  -11.65500 -14.48400 1.000 26.77600 ? 377 LEU   A N   1 
ATOM   1323 C CA  . LEU   A 1 181 ? -3.83600  -12.51900 -13.31100 1.000 32.69521 ? 377 LEU   A CA  1 
ATOM   1324 C C   . LEU   A 1 181 ? -2.90000  -13.69500 -13.58300 1.000 29.47831 ? 377 LEU   A C   1 
ATOM   1325 O O   . LEU   A 1 181 ? -2.16900  -14.14100 -12.68700 1.000 29.93638 ? 377 LEU   A O   1 
ATOM   1326 C CB  . LEU   A 1 181 ? -5.22000  -13.02900 -12.89400 1.000 31.44427 ? 377 LEU   A CB  1 
ATOM   1327 C CG  . LEU   A 1 181 ? -6.20300  -11.93900 -12.43700 1.000 34.09143 ? 377 LEU   A CG  1 
ATOM   1328 C CD1 . LEU   A 1 181 ? -7.63700  -12.49900 -12.36500 1.000 33.41741 ? 377 LEU   A CD1 1 
ATOM   1329 C CD2 . LEU   A 1 181 ? -5.77500  -11.39200 -11.09000 1.000 34.30547 ? 377 LEU   A CD2 1 
ATOM   1330 N N   . PHE   A 1 182 ? -2.97100  -14.24300 -14.79800 1.000 28.58755 ? 378 PHE   A N   1 
ATOM   1331 C CA  . PHE   A 1 182 ? -2.07700  -15.31700 -15.22400 1.000 30.31897 ? 378 PHE   A CA  1 
ATOM   1332 C C   . PHE   A 1 182 ? -0.62100  -14.87600 -15.12900 1.000 30.95422 ? 378 PHE   A C   1 
ATOM   1333 O O   . PHE   A 1 182 ? 0.22300   -15.57200 -14.55700 1.000 29.44930 ? 378 PHE   A O   1 
ATOM   1334 C CB  . PHE   A 1 182 ? -2.45600  -15.72000 -16.65500 1.000 32.92669 ? 378 PHE   A CB  1 
ATOM   1335 C CG  . PHE   A 1 182 ? -1.68000  -16.88800 -17.20100 1.000 34.91903 ? 378 PHE   A CG  1 
ATOM   1336 C CD1 . PHE   A 1 182 ? -1.99000  -18.19000 -16.80700 1.000 36.42118 ? 378 PHE   A CD1 1 
ATOM   1337 C CD2 . PHE   A 1 182 ? -0.66500  -16.69400 -18.12900 1.000 32.09308 ? 378 PHE   A CD2 1 
ATOM   1338 C CE1 . PHE   A 1 182 ? -1.28500  -19.27700 -17.31400 1.000 36.74992 ? 378 PHE   A CE1 1 
ATOM   1339 C CE2 . PHE   A 1 182 ? 0.04700   -17.78600 -18.64600 1.000 36.29064 ? 378 PHE   A CE2 1 
ATOM   1340 C CZ  . PHE   A 1 182 ? -0.26600  -19.07500 -18.22700 1.000 33.24512 ? 378 PHE   A CZ  1 
ATOM   1341 N N   . VAL   A 1 183 ? -0.31300  -13.69300 -15.64600 1.000 28.39256 ? 379 VAL   A N   1 
ATOM   1342 C CA  . VAL   A 1 183 ? 1.05800   -13.20500 -15.58200 1.000 30.07484 ? 379 VAL   A CA  1 
ATOM   1343 C C   . VAL   A 1 183 ? 1.47100   -12.95800 -14.13200 1.000 32.09406 ? 379 VAL   A C   1 
ATOM   1344 O O   . VAL   A 1 183 ? 2.60300   -13.25900 -13.73300 1.000 31.93478 ? 379 VAL   A O   1 
ATOM   1345 C CB  . VAL   A 1 183 ? 1.18000   -11.94800 -16.46200 1.000 29.85113 ? 379 VAL   A CB  1 
ATOM   1346 C CG1 . VAL   A 1 183 ? 2.52100   -11.18300 -16.23100 1.000 31.29164 ? 379 VAL   A CG1 1 
ATOM   1347 C CG2 . VAL   A 1 183 ? 1.00600   -12.35100 -17.92300 1.000 27.98501 ? 379 VAL   A CG2 1 
ATOM   1348 N N   . ALA   A 1 184 ? 0.56200   -12.42700 -13.31200 1.000 29.17322 ? 380 ALA   A N   1 
ATOM   1349 C CA  . ALA   A 1 184 ? 0.91300   -12.21000 -11.91200 1.000 31.13934 ? 380 ALA   A CA  1 
ATOM   1350 C C   . ALA   A 1 184 ? 1.22200   -13.53600 -11.21800 1.000 33.50478 ? 380 ALA   A C   1 
ATOM   1351 O O   . ALA   A 1 184 ? 2.15600   -13.62200 -10.41700 1.000 34.31204 ? 380 ALA   A O   1 
ATOM   1352 C CB  . ALA   A 1 184 ? -0.21300  -11.46900 -11.19700 1.000 30.99906 ? 380 ALA   A CB  1 
ATOM   1353 N N   . ALA   A 1 185 ? 0.46800   -14.59000 -11.55100 1.000 30.85494 ? 381 ALA   A N   1 
ATOM   1354 C CA  . ALA   A 1 185 ? 0.72900   -15.91100 -10.98600 1.000 33.22415 ? 381 ALA   A CA  1 
ATOM   1355 C C   . ALA   A 1 185 ? 2.10400   -16.43700 -11.39500 1.000 34.40380 ? 381 ALA   A C   1 
ATOM   1356 O O   . ALA   A 1 185 ? 2.81200   -17.05800 -10.59000 1.000 36.01668 ? 381 ALA   A O   1 
ATOM   1357 C CB  . ALA   A 1 185 ? -0.35900  -16.87400 -11.44000 1.000 31.39464 ? 381 ALA   A CB  1 
ATOM   1358 N N   . ILE   A 1 186 ? 2.48100   -16.21600 -12.65500 1.000 30.77156 ? 382 ILE   A N   1 
ATOM   1359 C CA  . ILE   A 1 186 ? 3.79900   -16.60100 -13.15400 1.000 31.50985 ? 382 ILE   A CA  1 
ATOM   1360 C C   . ILE   A 1 186 ? 4.90200   -15.92500 -12.33900 1.000 37.26786 ? 382 ILE   A C   1 
ATOM   1361 O O   . ILE   A 1 186 ? 5.84800   -16.57100 -11.86700 1.000 37.01572 ? 382 ILE   A O   1 
ATOM   1362 C CB  . ILE   A 1 186 ? 3.89900   -16.24400 -14.65000 1.000 32.30009 ? 382 ILE   A CB  1 
ATOM   1363 C CG1 . ILE   A 1 186 ? 2.99200   -17.18300 -15.45700 1.000 35.96370 ? 382 ILE   A CG1 1 
ATOM   1364 C CG2 . ILE   A 1 186 ? 5.38700   -16.21500 -15.11100 1.000 35.27636 ? 382 ILE   A CG2 1 
ATOM   1365 C CD1 . ILE   A 1 186 ? 2.88300   -16.83200 -16.94600 1.000 35.65384 ? 382 ILE   A CD1 1 
ATOM   1366 N N   . ILE   A 1 187 ? 4.79500   -14.60800 -12.16100 1.000 34.59956 ? 383 ILE   A N   1 
ATOM   1367 C CA  . ILE   A 1 187 ? 5.85000   -13.87800 -11.46500 1.000 37.41538 ? 383 ILE   A CA  1 
ATOM   1368 C C   . ILE   A 1 187 ? 5.96600   -14.32600 -10.00700 1.000 40.02845 ? 383 ILE   A C   1 
ATOM   1369 O O   . ILE   A 1 187 ? 7.07600   -14.54800 -9.49800  1.000 40.33473 ? 383 ILE   A O   1 
ATOM   1370 C CB  . ILE   A 1 187 ? 5.59700   -12.36800 -11.59300 1.000 36.41020 ? 383 ILE   A CB  1 
ATOM   1371 C CG1 . ILE   A 1 187 ? 5.91200   -11.92800 -13.02900 1.000 35.80891 ? 383 ILE   A CG1 1 
ATOM   1372 C CG2 . ILE   A 1 187 ? 6.46200   -11.58500 -10.62100 1.000 38.52251 ? 383 ILE   A CG2 1 
ATOM   1373 C CD1 . ILE   A 1 187 ? 5.31600   -10.60400 -13.35400 1.000 41.46282 ? 383 ILE   A CD1 1 
ATOM   1374 N N   . CYS   A 1 188 ? 4.83600   -14.46600 -9.31000  1.000 35.78781 ? 384 CYS   A N   1 
ATOM   1375 C CA  . CYS   A 1 188 ? 4.84600   -14.78200 -7.87900  1.000 41.17082 ? 384 CYS   A CA  1 
ATOM   1376 C C   . CYS   A 1 188 ? 4.82100   -16.29700 -7.69600  1.000 42.98594 ? 384 CYS   A C   1 
ATOM   1377 O O   . CYS   A 1 188 ? 3.83000   -16.89600 -7.29200  1.000 43.39849 ? 384 CYS   A O   1 
ATOM   1378 C CB  . CYS   A 1 188 ? 3.67700   -14.11500 -7.17200  1.000 40.68871 ? 384 CYS   A CB  1 
ATOM   1379 S SG  . CYS   A 1 188 ? 3.67200   -12.34800 -7.35800  1.000 46.72314 ? 384 CYS   A SG  1 
ATOM   1380 N N   . CYS   A 1 189 ? 5.95600   -16.90900 -8.01100  1.000 45.59284 ? 385 CYS   A N   1 
ATOM   1381 C CA  . CYS   A 1 189 ? 6.09800   -18.35900 -8.05200  1.000 43.97255 ? 385 CYS   A CA  1 
ATOM   1382 C C   . CYS   A 1 189 ? 7.01400   -18.81800 -6.92600  1.000 45.94315 ? 385 CYS   A C   1 
ATOM   1383 O O   . CYS   A 1 189 ? 8.21500   -18.52600 -6.94200  1.000 45.29769 ? 385 CYS   A O   1 
ATOM   1384 C CB  . CYS   A 1 189 ? 6.66300   -18.79900 -9.39800  1.000 45.36587 ? 385 CYS   A CB  1 
ATOM   1385 S SG  . CYS   A 1 189 ? 6.63900   -20.58200 -9.59100  1.000 50.66408 ? 385 CYS   A SG  1 
ATOM   1386 N N   . GLY   A 1 190 ? 6.45500   -19.55600 -5.97600  1.000 40.75533 ? 386 GLY   A N   1 
ATOM   1387 C CA  . GLY   A 1 190 ? 7.18700   -19.98500 -4.81300  1.000 43.55713 ? 386 GLY   A CA  1 
ATOM   1388 C C   . GLY   A 1 190 ? 8.18200   -21.10400 -5.02000  1.000 47.61918 ? 386 GLY   A C   1 
ATOM   1389 O O   . GLY   A 1 190 ? 8.84000   -21.48400 -4.05200  1.000 49.24912 ? 386 GLY   A O   1 
ATOM   1390 N N   . ASP   A 1 191 ? 8.34500   -21.64600 -6.22800  1.000 46.11850 ? 387 ASP   A N   1 
ATOM   1391 C CA  . ASP   A 1 191 ? 9.30700   -22.72800 -6.40800  1.000 51.86887 ? 387 ASP   A CA  1 
ATOM   1392 C C   . ASP   A 1 191 ? 10.47100  -22.33000 -7.30500  1.000 51.40976 ? 387 ASP   A C   1 
ATOM   1393 O O   . ASP   A 1 191 ? 11.13100  -23.19800 -7.88900  1.000 50.53073 ? 387 ASP   A O   1 
ATOM   1394 C CB  . ASP   A 1 191 ? 8.62800   -24.00700 -6.92200  1.000 51.13364 ? 387 ASP   A CB  1 
ATOM   1395 C CG  . ASP   A 1 191 ? 7.97400   -23.84400 -8.28100  1.000 61.56825 ? 387 ASP   A CG  1 
ATOM   1396 O OD1 . ASP   A 1 191 ? 8.48300   -23.06700 -9.12300  1.000 60.57606 ? 387 ASP   A OD1 1 
ATOM   1397 O OD2 . ASP   A 1 191 ? 6.96400   -24.54900 -8.52700  1.000 66.58790 ? 387 ASP   A OD2 1 
ATOM   1398 N N   . ARG   A 1 192 ? 10.74700  -21.04000 -7.42200  1.000 46.96554 ? 388 ARG   A N   1 
ATOM   1399 C CA  . ARG   A 1 192 ? 11.91100  -20.62600 -8.17700  1.000 48.36067 ? 388 ARG   A CA  1 
ATOM   1400 C C   . ARG   A 1 192 ? 13.17000  -21.00100 -7.39300  1.000 47.89604 ? 388 ARG   A C   1 
ATOM   1401 O O   . ARG   A 1 192 ? 13.16900  -20.94900 -6.16200  1.000 47.52814 ? 388 ARG   A O   1 
ATOM   1402 C CB  . ARG   A 1 192 ? 11.87700  -19.12100 -8.44500  1.000 45.37101 ? 388 ARG   A CB  1 
ATOM   1403 C CG  . ARG   A 1 192 ? 10.63500  -18.63300 -9.18000  1.000 38.88204 ? 388 ARG   A CG  1 
ATOM   1404 C CD  . ARG   A 1 192 ? 10.41000  -19.35900 -10.50600 1.000 42.46559 ? 388 ARG   A CD  1 
ATOM   1405 N NE  . ARG   A 1 192 ? 9.34400   -18.72600 -11.28300 1.000 42.58664 ? 388 ARG   A NE  1 
ATOM   1406 C CZ  . ARG   A 1 192 ? 8.88400   -19.17300 -12.44500 1.000 43.29720 ? 388 ARG   A CZ  1 
ATOM   1407 N NH1 . ARG   A 1 192 ? 9.36400   -20.27300 -13.00200 1.000 39.49589 ? 388 ARG   A NH1 1 
ATOM   1408 N NH2 . ARG   A 1 192 ? 7.92300   -18.49000 -13.07100 1.000 38.12066 ? 388 ARG   A NH2 1 
ATOM   1409 N N   . PRO   A 1 193 ? 14.24200  -21.40700 -8.07700  1.000 53.61885 ? 389 PRO   A N   1 
ATOM   1410 C CA  . PRO   A 1 193 ? 15.43900  -21.86700 -7.35700  1.000 50.43517 ? 389 PRO   A CA  1 
ATOM   1411 C C   . PRO   A 1 193 ? 16.08300  -20.72500 -6.58900  1.000 54.00591 ? 389 PRO   A C   1 
ATOM   1412 O O   . PRO   A 1 193 ? 16.20300  -19.60700 -7.09600  1.000 58.34133 ? 389 PRO   A O   1 
ATOM   1413 C CB  . PRO   A 1 193 ? 16.35900  -22.37100 -8.47900  1.000 49.83218 ? 389 PRO   A CB  1 
ATOM   1414 C CG  . PRO   A 1 193 ? 15.48900  -22.50300 -9.68900  1.000 49.75441 ? 389 PRO   A CG  1 
ATOM   1415 C CD  . PRO   A 1 193 ? 14.41100  -21.47300 -9.53700  1.000 47.90954 ? 389 PRO   A CD  1 
ATOM   1416 N N   . GLY   A 1 194 ? 16.48100  -21.00900 -5.35000  1.000 49.92402 ? 390 GLY   A N   1 
ATOM   1417 C CA  . GLY   A 1 194 ? 17.21100  -20.04200 -4.56400  1.000 49.05978 ? 390 GLY   A CA  1 
ATOM   1418 C C   . GLY   A 1 194 ? 16.36000  -19.02800 -3.84000  1.000 50.18913 ? 390 GLY   A C   1 
ATOM   1419 O O   . GLY   A 1 194 ? 16.89700  -18.03100 -3.34900  1.000 52.30598 ? 390 GLY   A O   1 
ATOM   1420 N N   . LEU   A 1 195 ? 15.05100  -19.23800 -3.76300  1.000 50.34294 ? 391 LEU   A N   1 
ATOM   1421 C CA  . LEU   A 1 195 ? 14.20000  -18.32700 -3.01300  1.000 48.83412 ? 391 LEU   A CA  1 
ATOM   1422 C C   . LEU   A 1 195 ? 14.46000  -18.49600 -1.52400  1.000 57.02204 ? 391 LEU   A C   1 
ATOM   1423 O O   . LEU   A 1 195 ? 14.72500  -19.60500 -1.04400  1.000 57.53435 ? 391 LEU   A O   1 
ATOM   1424 C CB  . LEU   A 1 195 ? 12.72600  -18.59800 -3.31500  1.000 47.80671 ? 391 LEU   A CB  1 
ATOM   1425 C CG  . LEU   A 1 195 ? 12.16000  -17.91800 -4.56300  1.000 47.51065 ? 391 LEU   A CG  1 
ATOM   1426 C CD1 . LEU   A 1 195 ? 10.68200  -18.23400 -4.68900  1.000 42.30005 ? 391 LEU   A CD1 1 
ATOM   1427 C CD2 . LEU   A 1 195 ? 12.39200  -16.41400 -4.49500  1.000 40.96321 ? 391 LEU   A CD2 1 
ATOM   1428 N N   . LEU   A 1 196 ? 14.37300  -17.39100 -0.78900  1.000 51.43000 ? 392 LEU   A N   1 
ATOM   1429 C CA  . LEU   A 1 196 ? 14.52600  -17.45700 0.65800   1.000 54.67749 ? 392 LEU   A CA  1 
ATOM   1430 C C   . LEU   A 1 196 ? 13.16800  -17.54700 1.34500   1.000 54.79633 ? 392 LEU   A C   1 
ATOM   1431 O O   . LEU   A 1 196 ? 12.87700  -18.52900 2.03600   1.000 56.82639 ? 392 LEU   A O   1 
ATOM   1432 C CB  . LEU   A 1 196 ? 15.32900  -16.24900 1.16200   1.000 58.27753 ? 392 LEU   A CB  1 
ATOM   1433 C CG  . LEU   A 1 196 ? 16.86200  -16.34500 1.03700   1.000 62.22142 ? 392 LEU   A CG  1 
ATOM   1434 C CD1 . LEU   A 1 196 ? 17.39300  -17.71300 1.48900   1.000 59.55765 ? 392 LEU   A CD1 1 
ATOM   1435 C CD2 . LEU   A 1 196 ? 17.30500  -16.05600 -0.39600  1.000 62.02719 ? 392 LEU   A CD2 1 
ATOM   1436 N N   . ASN   A 1 197 ? 12.31700  -16.54200 1.15600   1.000 48.64622 ? 393 ASN   A N   1 
ATOM   1437 C CA  . ASN   A 1 197 ? 11.04100  -16.50500 1.86900   1.000 50.67998 ? 393 ASN   A CA  1 
ATOM   1438 C C   . ASN   A 1 197 ? 9.95300   -17.26800 1.10100   1.000 49.52933 ? 393 ASN   A C   1 
ATOM   1439 O O   . ASN   A 1 197 ? 8.91900   -16.71900 0.70800   1.000 48.65723 ? 393 ASN   A O   1 
ATOM   1440 C CB  . ASN   A 1 197 ? 10.63700  -15.06300 2.14500   1.000 46.32591 ? 393 ASN   A CB  1 
ATOM   1441 C CG  . ASN   A 1 197 ? 9.50400   -14.97000 3.13600   1.000 48.14377 ? 393 ASN   A CG  1 
ATOM   1442 O OD1 . ASN   A 1 197 ? 8.94000   -15.98000 3.53400   1.000 50.75997 ? 393 ASN   A OD1 1 
ATOM   1443 N ND2 . ASN   A 1 197 ? 9.16500   -13.76400 3.53600   1.000 48.63220 ? 393 ASN   A ND2 1 
ATOM   1444 N N   . VAL   A 1 198 ? 10.19700  -18.57200 0.92600   1.000 50.38749 ? 394 VAL   A N   1 
ATOM   1445 C CA  . VAL   A 1 198 ? 9.30500   -19.42300 0.13400   1.000 45.93956 ? 394 VAL   A CA  1 
ATOM   1446 C C   . VAL   A 1 198 ? 7.88700   -19.41000 0.71100   1.000 50.03232 ? 394 VAL   A C   1 
ATOM   1447 O O   . VAL   A 1 198 ? 6.89900   -19.30200 -0.02500  1.000 49.48159 ? 394 VAL   A O   1 
ATOM   1448 C CB  . VAL   A 1 198 ? 9.85900   -20.85900 0.05500   1.000 52.85431 ? 394 VAL   A CB  1 
ATOM   1449 C CG1 . VAL   A 1 198 ? 8.88700   -21.77200 -0.68000  1.000 49.10376 ? 394 VAL   A CG1 1 
ATOM   1450 C CG2 . VAL   A 1 198 ? 11.20300  -20.88300 -0.64300  1.000 54.19574 ? 394 VAL   A CG2 1 
ATOM   1451 N N   . GLY   A 1 199 ? 7.76500   -19.53500 2.03300   1.000 52.98901 ? 395 GLY   A N   1 
ATOM   1452 C CA  . GLY   A 1 199 ? 6.44300   -19.66500 2.63200   1.000 49.53934 ? 395 GLY   A CA  1 
ATOM   1453 C C   . GLY   A 1 199 ? 5.55300   -18.46400 2.36500   1.000 49.86924 ? 395 GLY   A C   1 
ATOM   1454 O O   . GLY   A 1 199 ? 4.34400   -18.60500 2.15300   1.000 49.12752 ? 395 GLY   A O   1 
ATOM   1455 N N   . HIS   A 1 200 ? 6.14000   -17.26900 2.35600   1.000 46.20129 ? 396 HIS   A N   1 
ATOM   1456 C CA  . HIS   A 1 200 ? 5.35800   -16.07100 2.08200   1.000 48.28868 ? 396 HIS   A CA  1 
ATOM   1457 C C   . HIS   A 1 200 ? 5.05800   -15.91400 0.59000   1.000 48.63194 ? 396 HIS   A C   1 
ATOM   1458 O O   . HIS   A 1 200 ? 3.98200   -15.43000 0.22200   1.000 47.46966 ? 396 HIS   A O   1 
ATOM   1459 C CB  . HIS   A 1 200 ? 6.08900   -14.83900 2.59900   1.000 48.56680 ? 396 HIS   A CB  1 
ATOM   1460 C CG  . HIS   A 1 200 ? 5.38000   -13.56400 2.30100   1.000 53.97091 ? 396 HIS   A CG  1 
ATOM   1461 N ND1 . HIS   A 1 200 ? 5.92100   -12.58300 1.50100   1.000 56.70677 ? 396 HIS   A ND1 1 
ATOM   1462 C CD2 . HIS   A 1 200 ? 4.15900   -13.11500 2.67800   1.000 60.50636 ? 396 HIS   A CD2 1 
ATOM   1463 C CE1 . HIS   A 1 200 ? 5.06900   -11.57600 1.40600   1.000 59.47311 ? 396 HIS   A CE1 1 
ATOM   1464 N NE2 . HIS   A 1 200 ? 3.99300   -11.87300 2.11200   1.000 59.99531 ? 396 HIS   A NE2 1 
ATOM   1465 N N   . ILE   A 1 201 ? 5.99700   -16.27800 -0.28400  1.000 43.89263 ? 397 ILE   A N   1 
ATOM   1466 C CA  . ILE   A 1 201 ? 5.72400   -16.16800 -1.71700  1.000 44.02705 ? 397 ILE   A CA  1 
ATOM   1467 C C   . ILE   A 1 201 ? 4.68300   -17.20100 -2.12800  1.000 42.98470 ? 397 ILE   A C   1 
ATOM   1468 O O   . ILE   A 1 201 ? 3.75100   -16.90000 -2.88400  1.000 39.07554 ? 397 ILE   A O   1 
ATOM   1469 C CB  . ILE   A 1 201 ? 7.02900   -16.30000 -2.52100  1.000 40.98464 ? 397 ILE   A CB  1 
ATOM   1470 C CG1 . ILE   A 1 201 ? 7.94300   -15.11300 -2.21300  1.000 40.66664 ? 397 ILE   A CG1 1 
ATOM   1471 C CG2 . ILE   A 1 201 ? 6.74700   -16.40400 -4.02800  1.000 42.30096 ? 397 ILE   A CG2 1 
ATOM   1472 C CD1 . ILE   A 1 201 ? 9.37000   -15.34500 -2.58100  1.000 45.29624 ? 397 ILE   A CD1 1 
ATOM   1473 N N   . GLU   A 1 202 ? 4.79700   -18.42100 -1.59600  1.000 44.70198 ? 398 GLU   A N   1 
ATOM   1474 C CA  . GLU   A 1 202 ? 3.76100   -19.42800 -1.81100  1.000 47.74195 ? 398 GLU   A CA  1 
ATOM   1475 C C   . GLU   A 1 202 ? 2.39400   -18.90900 -1.37200  1.000 44.48289 ? 398 GLU   A C   1 
ATOM   1476 O O   . GLU   A 1 202 ? 1.38200   -19.17800 -2.02600  1.000 42.24889 ? 398 GLU   A O   1 
ATOM   1477 C CB  . GLU   A 1 202 ? 4.12400   -20.71300 -1.05900  1.000 45.29659 ? 398 GLU   A CB  1 
ATOM   1478 C CG  . GLU   A 1 202 ? 5.00800   -21.67000 -1.85900  1.000 51.58313 ? 398 GLU   A CG  1 
ATOM   1479 C CD  . GLU   A 1 202 ? 5.40700   -22.91900 -1.07200  1.000 61.68522 ? 398 GLU   A CD  1 
ATOM   1480 O OE1 . GLU   A 1 202 ? 6.05400   -23.81700 -1.66400  1.000 61.27449 ? 398 GLU   A OE1 1 
ATOM   1481 O OE2 . GLU   A 1 202 ? 5.09000   -22.99600 0.13900   1.000 62.20077 ? 398 GLU   A OE2 1 
ATOM   1482 N N   . LYS   A 1 203 ? 2.34900   -18.15400 -0.26800  1.000 43.62892 ? 399 LYS   A N   1 
ATOM   1483 C CA  . LYS   A 1 203 ? 1.08300   -17.58200 0.18000   1.000 46.54924 ? 399 LYS   A CA  1 
ATOM   1484 C C   . LYS   A 1 203 ? 0.59300   -16.50300 -0.77800  1.000 44.85787 ? 399 LYS   A C   1 
ATOM   1485 O O   . LYS   A 1 203 ? -0.61600  -16.38800 -1.02600  1.000 40.79179 ? 399 LYS   A O   1 
ATOM   1486 C CB  . LYS   A 1 203 ? 1.22500   -17.02000 1.59100   1.000 46.84864 ? 399 LYS   A CB  1 
ATOM   1487 C CG  . LYS   A 1 203 ? -0.07100  -16.44300 2.15400   1.000 50.61496 ? 399 LYS   A CG  1 
ATOM   1488 C CD  . LYS   A 1 203 ? -1.23400  -17.43400 2.03000   1.000 57.73928 ? 399 LYS   A CD  1 
ATOM   1489 C CE  . LYS   A 1 203 ? -2.11100  -17.43100 3.27800   1.000 55.93132 ? 399 LYS   A CE  1 
ATOM   1490 N NZ  . LYS   A 1 203 ? -3.11100  -16.32400 3.22600   1.000 64.12370 ? 399 LYS   A NZ  1 
ATOM   1491 N N   . MET   A 1 204 ? 1.51200   -15.69300 -1.31000  1.000 42.44377 ? 400 MET   A N   1 
ATOM   1492 C CA  . MET   A 1 204 ? 1.13000   -14.72500 -2.33500  1.000 42.84322 ? 400 MET   A CA  1 
ATOM   1493 C C   . MET   A 1 204 ? 0.55400   -15.43500 -3.54600  1.000 42.61736 ? 400 MET   A C   1 
ATOM   1494 O O   . MET   A 1 204 ? -0.48800  -15.02400 -4.07600  1.000 39.54543 ? 400 MET   A O   1 
ATOM   1495 C CB  . MET   A 1 204 ? 2.33100   -13.87500 -2.76300  1.000 40.28450 ? 400 MET   A CB  1 
ATOM   1496 C CG  . MET   A 1 204 ? 2.97200   -13.09900 -1.64300  1.000 50.78665 ? 400 MET   A CG  1 
ATOM   1497 S SD  . MET   A 1 204 ? 4.13200   -11.82100 -2.18700  1.000 59.57619 ? 400 MET   A SD  1 
ATOM   1498 C CE  . MET   A 1 204 ? 3.83900   -11.71800 -3.94600  1.000 49.37279 ? 400 MET   A CE  1 
ATOM   1499 N N   . GLN   A 1 205 ? 1.20800   -16.51400 -3.99500  1.000 35.13351 ? 401 GLN   A N   1 
ATOM   1500 C CA  . GLN   A 1 205 ? 0.69800   -17.19900 -5.18000  1.000 39.05747 ? 401 GLN   A CA  1 
ATOM   1501 C C   . GLN   A 1 205 ? -0.68000  -17.79000 -4.92400  1.000 41.55560 ? 401 GLN   A C   1 
ATOM   1502 O O   . GLN   A 1 205 ? -1.54800  -17.77800 -5.80800  1.000 37.17889 ? 401 GLN   A O   1 
ATOM   1503 C CB  . GLN   A 1 205 ? 1.64400   -18.30200 -5.64300  1.000 41.09560 ? 401 GLN   A CB  1 
ATOM   1504 C CG  . GLN   A 1 205 ? 1.15600   -18.85700 -6.97800  1.000 44.35325 ? 401 GLN   A CG  1 
ATOM   1505 C CD  . GLN   A 1 205 ? 2.14500   -19.75800 -7.66700  1.000 50.80042 ? 401 GLN   A CD  1 
ATOM   1506 O OE1 . GLN   A 1 205 ? 2.51500   -20.80800 -7.14000  1.000 51.10027 ? 401 GLN   A OE1 1 
ATOM   1507 N NE2 . GLN   A 1 205 ? 2.56300   -19.36700 -8.87300  1.000 44.81532 ? 401 GLN   A NE2 1 
ATOM   1508 N N   . GLU   A 1 206 ? -0.89400  -18.33100 -3.72500  1.000 40.23919 ? 402 GLU   A N   1 
ATOM   1509 C CA  . GLU   A 1 206 ? -2.18100  -18.93800 -3.41700  1.000 44.59563 ? 402 GLU   A CA  1 
ATOM   1510 C C   . GLU   A 1 206 ? -3.30500  -17.92700 -3.57800  1.000 38.40190 ? 402 GLU   A C   1 
ATOM   1511 O O   . GLU   A 1 206 ? -4.35600  -18.23900 -4.15000  1.000 38.09166 ? 402 GLU   A O   1 
ATOM   1512 C CB  . GLU   A 1 206 ? -2.17100  -19.48900 -1.99200  1.000 46.23180 ? 402 GLU   A CB  1 
ATOM   1513 C CG  . GLU   A 1 206 ? -1.50600  -20.83100 -1.82000  1.000 52.03256 ? 402 GLU   A CG  1 
ATOM   1514 C CD  . GLU   A 1 206 ? -1.50600  -21.27200 -0.35400  1.000 60.65725 ? 402 GLU   A CD  1 
ATOM   1515 O OE1 . GLU   A 1 206 ? -0.65900  -22.12000 0.02400   1.000 67.22465 ? 402 GLU   A OE1 1 
ATOM   1516 O OE2 . GLU   A 1 206 ? -2.34000  -20.74700 0.42200   1.000 55.73388 ? 402 GLU   A OE2 1 
ATOM   1517 N N   . GLY   A 1 207 ? -3.10400  -16.71500 -3.05700  1.000 37.01945 ? 403 GLY   A N   1 
ATOM   1518 C CA  . GLY   A 1 207 ? -4.09900  -15.66500 -3.23300  1.000 36.54934 ? 403 GLY   A CA  1 
ATOM   1519 C C   . GLY   A 1 207 ? -4.33900  -15.31700 -4.69000  1.000 37.63467 ? 403 GLY   A C   1 
ATOM   1520 O O   . GLY   A 1 207 ? -5.48800  -15.22700 -5.13400  1.000 39.89584 ? 403 GLY   A O   1 
ATOM   1521 N N   . ILE   A 1 208 ? -3.25700  -15.11700 -5.46000  1.000 38.25768 ? 404 ILE   A N   1 
ATOM   1522 C CA  . ILE   A 1 208 ? -3.39000  -14.76000 -6.87700  1.000 33.57057 ? 404 ILE   A CA  1 
ATOM   1523 C C   . ILE   A 1 208 ? -4.10500  -15.87000 -7.63500  1.000 35.13505 ? 404 ILE   A C   1 
ATOM   1524 O O   . ILE   A 1 208 ? -5.05800  -15.62300 -8.38300  1.000 36.33065 ? 404 ILE   A O   1 
ATOM   1525 C CB  . ILE   A 1 208 ? -2.01000  -14.46100 -7.50000  1.000 34.88570 ? 404 ILE   A CB  1 
ATOM   1526 C CG1 . ILE   A 1 208 ? -1.39200  -13.20300 -6.88100  1.000 36.20407 ? 404 ILE   A CG1 1 
ATOM   1527 C CG2 . ILE   A 1 208 ? -2.12400  -14.33100 -9.04600  1.000 31.99655 ? 404 ILE   A CG2 1 
ATOM   1528 C CD1 . ILE   A 1 208 ? 0.06400   -13.00100 -7.25400  1.000 40.48121 ? 404 ILE   A CD1 1 
ATOM   1529 N N   . VAL   A 1 209 ? -3.68600  -17.12000 -7.41800  1.000 35.75612 ? 405 VAL   A N   1 
ATOM   1530 C CA  . VAL   A 1 209 ? -4.29900  -18.24300 -8.12600  1.000 35.11005 ? 405 VAL   A CA  1 
ATOM   1531 C C   . VAL   A 1 209 ? -5.76500  -18.38400 -7.73300  1.000 38.56550 ? 405 VAL   A C   1 
ATOM   1532 O O   . VAL   A 1 209 ? -6.61800  -18.73100 -8.56400  1.000 34.93435 ? 405 VAL   A O   1 
ATOM   1533 C CB  . VAL   A 1 209 ? -3.49600  -19.53400 -7.85600  1.000 38.31731 ? 405 VAL   A CB  1 
ATOM   1534 C CG1 . VAL   A 1 209 ? -4.28100  -20.76500 -8.25100  1.000 37.82940 ? 405 VAL   A CG1 1 
ATOM   1535 C CG2 . VAL   A 1 209 ? -2.18100  -19.48700 -8.63300  1.000 35.33301 ? 405 VAL   A CG2 1 
ATOM   1536 N N   . HIS   A 1 210 ? -6.08300  -18.10400 -6.46700  1.000 35.85908 ? 406 HIS   A N   1 
ATOM   1537 C CA  . HIS   A 1 210 ? -7.46800  -18.18700 -6.00800  1.000 39.03279 ? 406 HIS   A CA  1 
ATOM   1538 C C   . HIS   A 1 210 ? -8.34000  -17.15400 -6.71500  1.000 38.28727 ? 406 HIS   A C   1 
ATOM   1539 O O   . HIS   A 1 210 ? -9.41200  -17.48300 -7.23300  1.000 39.35138 ? 406 HIS   A O   1 
ATOM   1540 C CB  . HIS   A 1 210 ? -7.50900  -17.99600 -4.49000  1.000 40.43244 ? 406 HIS   A CB  1 
ATOM   1541 C CG  . HIS   A 1 210 ? -8.88900  -17.99400 -3.89300  1.000 49.27014 ? 406 HIS   A CG  1 
ATOM   1542 N ND1 . HIS   A 1 210 ? -9.99200  -18.52800 -4.53100  1.000 51.41108 ? 406 HIS   A ND1 1 
ATOM   1543 C CD2 . HIS   A 1 210 ? -9.33400  -17.54400 -2.69500  1.000 50.23228 ? 406 HIS   A CD2 1 
ATOM   1544 C CE1 . HIS   A 1 210 ? -11.05500 -18.39400 -3.75700  1.000 50.47550 ? 406 HIS   A CE1 1 
ATOM   1545 N NE2 . HIS   A 1 210 ? -10.68200 -17.80500 -2.63600  1.000 49.62445 ? 406 HIS   A NE2 1 
ATOM   1546 N N   . VAL   A 1 211 ? -7.88600  -15.89600 -6.78000  1.000 37.47295 ? 407 VAL   A N   1 
ATOM   1547 C CA  . VAL   A 1 211 ? -8.72500  -14.91300 -7.45500  1.000 37.51671 ? 407 VAL   A CA  1 
ATOM   1548 C C   . VAL   A 1 211 ? -8.76500  -15.17800 -8.95900  1.000 39.31244 ? 407 VAL   A C   1 
ATOM   1549 O O   . VAL   A 1 211 ? -9.76400  -14.86300 -9.62200  1.000 38.08972 ? 407 VAL   A O   1 
ATOM   1550 C CB  . VAL   A 1 211 ? -8.28200  -13.47300 -7.13200  1.000 42.72387 ? 407 VAL   A CB  1 
ATOM   1551 C CG1 . VAL   A 1 211 ? -8.11100  -13.29500 -5.63400  1.000 46.50612 ? 407 VAL   A CG1 1 
ATOM   1552 C CG2 . VAL   A 1 211 ? -7.01200  -13.10800 -7.86100  1.000 41.76031 ? 407 VAL   A CG2 1 
ATOM   1553 N N   . LEU   A 1 212 ? -7.71500  -15.78300 -9.52700  1.000 34.87086 ? 408 LEU   A N   1 
ATOM   1554 C CA  . LEU   A 1 212 ? -7.78000  -16.14400 -10.94500 1.000 34.19387 ? 408 LEU   A CA  1 
ATOM   1555 C C   . LEU   A 1 212 ? -8.87200  -17.18200 -11.19100 1.000 36.11452 ? 408 LEU   A C   1 
ATOM   1556 O O   . LEU   A 1 212 ? -9.66900  -17.05900 -12.13000 1.000 35.16560 ? 408 LEU   A O   1 
ATOM   1557 C CB  . LEU   A 1 212 ? -6.42000  -16.66700 -11.41600 1.000 34.88665 ? 408 LEU   A CB  1 
ATOM   1558 C CG  . LEU   A 1 212 ? -6.39900  -17.38800 -12.76700 1.000 36.52278 ? 408 LEU   A CG  1 
ATOM   1559 C CD1 . LEU   A 1 212 ? -6.74600  -16.38700 -13.89300 1.000 30.23135 ? 408 LEU   A CD1 1 
ATOM   1560 C CD2 . LEU   A 1 212 ? -5.02100  -17.98800 -13.00600 1.000 34.47488 ? 408 LEU   A CD2 1 
ATOM   1561 N N   . ARG   A 1 213 ? -8.90800  -18.23000 -10.36600 1.000 33.32555 ? 409 ARG   A N   1 
ATOM   1562 C CA  . ARG   A 1 213 ? -9.94500  -19.24700 -10.50300 1.000 41.06005 ? 409 ARG   A CA  1 
ATOM   1563 C C   . ARG   A 1 213 ? -11.34500 -18.63600 -10.37800 1.000 37.29592 ? 409 ARG   A C   1 
ATOM   1564 O O   . ARG   A 1 213 ? -12.25100 -18.96300 -11.15300 1.000 40.42669 ? 409 ARG   A O   1 
ATOM   1565 C CB  . ARG   A 1 213 ? -9.74200  -20.34100 -9.44400  1.000 42.23124 ? 409 ARG   A CB  1 
ATOM   1566 C CG  . ARG   A 1 213 ? -11.01700 -21.13500 -9.16700  1.000 49.32155 ? 409 ARG   A CG  1 
ATOM   1567 C CD  . ARG   A 1 213 ? -10.79900 -22.39400 -8.31600  1.000 54.13231 ? 409 ARG   A CD  1 
ATOM   1568 N NE  . ARG   A 1 213 ? -9.99100  -22.20300 -7.11600  1.000 54.60802 ? 409 ARG   A NE  1 
ATOM   1569 C CZ  . ARG   A 1 213 ? -10.48300 -21.88900 -5.92300  1.000 60.97715 ? 409 ARG   A CZ  1 
ATOM   1570 N NH1 . ARG   A 1 213 ? -11.78200 -21.67900 -5.74400  1.000 58.92237 ? 409 ARG   A NH1 1 
ATOM   1571 N NH2 . ARG   A 1 213 ? -9.65300  -21.78100 -4.88300  1.000 56.44157 ? 409 ARG   A NH2 1 
ATOM   1572 N N   . LEU   A 1 214 ? -11.53700 -17.75100 -9.40300  1.000 40.45497 ? 410 LEU   A N   1 
ATOM   1573 C CA  . LEU   A 1 214 ? -12.83800 -17.11400 -9.24200  1.000 43.47483 ? 410 LEU   A CA  1 
ATOM   1574 C C   . LEU   A 1 214 ? -13.13900 -16.20800 -10.42800 1.000 42.93699 ? 410 LEU   A C   1 
ATOM   1575 O O   . LEU   A 1 214 ? -14.26800 -16.18400 -10.92900 1.000 42.73049 ? 410 LEU   A O   1 
ATOM   1576 C CB  . LEU   A 1 214 ? -12.87300 -16.34600 -7.91400  1.000 39.65465 ? 410 LEU   A CB  1 
ATOM   1577 C CG  . LEU   A 1 214 ? -13.44400 -17.12900 -6.72400  1.000 47.74788 ? 410 LEU   A CG  1 
ATOM   1578 C CD1 . LEU   A 1 214 ? -14.95200 -17.25200 -6.82200  1.000 51.68599 ? 410 LEU   A CD1 1 
ATOM   1579 C CD2 . LEU   A 1 214 ? -12.84400 -18.52800 -6.63600  1.000 52.30885 ? 410 LEU   A CD2 1 
ATOM   1580 N N   . HIS   A 1 215 ? -12.12500 -15.48600 -10.92300 1.000 37.85280 ? 411 HIS   A N   1 
ATOM   1581 C CA  . HIS   A 1 215 ? -12.34200 -14.62600 -12.08300 1.000 41.13365 ? 411 HIS   A CA  1 
ATOM   1582 C C   . HIS   A 1 215 ? -12.71000 -15.43700 -13.31700 1.000 41.80503 ? 411 HIS   A C   1 
ATOM   1583 O O   . HIS   A 1 215 ? -13.61000 -15.04900 -14.07000 1.000 43.51041 ? 411 HIS   A O   1 
ATOM   1584 C CB  . HIS   A 1 215 ? -11.09600 -13.77400 -12.34900 1.000 39.73027 ? 411 HIS   A CB  1 
ATOM   1585 C CG  . HIS   A 1 215 ? -11.23400 -12.85300 -13.51700 1.000 41.39015 ? 411 HIS   A CG  1 
ATOM   1586 N ND1 . HIS   A 1 215 ? -12.01400 -11.71800 -13.48300 1.000 44.59677 ? 411 HIS   A ND1 1 
ATOM   1587 C CD2 . HIS   A 1 215 ? -10.67700 -12.89000 -14.75100 1.000 42.28307 ? 411 HIS   A CD2 1 
ATOM   1588 C CE1 . HIS   A 1 215 ? -11.94200 -11.10400 -14.65100 1.000 44.45339 ? 411 HIS   A CE1 1 
ATOM   1589 N NE2 . HIS   A 1 215 ? -11.13600 -11.79300 -15.43900 1.000 40.36025 ? 411 HIS   A NE2 1 
ATOM   1590 N N   . LEU   A 1 216 ? -12.03900 -16.57400 -13.54100 1.000 40.13647 ? 412 LEU   A N   1 
ATOM   1591 C CA  . LEU   A 1 216 ? -12.36300 -17.37900 -14.72000 1.000 42.56518 ? 412 LEU   A CA  1 
ATOM   1592 C C   . LEU   A 1 216 ? -13.77600 -17.93500 -14.63300 1.000 42.44786 ? 412 LEU   A C   1 
ATOM   1593 O O   . LEU   A 1 216 ? -14.42700 -18.16800 -15.65800 1.000 46.02373 ? 412 LEU   A O   1 
ATOM   1594 C CB  . LEU   A 1 216 ? -11.37300 -18.53600 -14.88500 1.000 39.20643 ? 412 LEU   A CB  1 
ATOM   1595 C CG  . LEU   A 1 216 ? -9.89300  -18.20300 -15.09900 1.000 41.78299 ? 412 LEU   A CG  1 
ATOM   1596 C CD1 . LEU   A 1 216 ? -9.03100  -19.48400 -15.02400 1.000 41.98917 ? 412 LEU   A CD1 1 
ATOM   1597 C CD2 . LEU   A 1 216 ? -9.70000  -17.52300 -16.42400 1.000 40.70415 ? 412 LEU   A CD2 1 
ATOM   1598 N N   . GLN   A 1 217 ? -14.25000 -18.17400 -13.42400 1.000 44.10064 ? 413 GLN   A N   1 
ATOM   1599 C CA  . GLN   A 1 217 ? -15.56700 -18.77200 -13.24400 1.000 51.98419 ? 413 GLN   A CA  1 
ATOM   1600 C C   . GLN   A 1 217 ? -16.66900 -17.83800 -13.73600 1.000 49.57902 ? 413 GLN   A C   1 
ATOM   1601 O O   . GLN   A 1 217 ? -17.62200 -18.28500 -14.37600 1.000 53.34127 ? 413 GLN   A O   1 
ATOM   1602 C CB  . GLN   A 1 217 ? -15.74800 -19.12600 -11.77100 1.000 48.84254 ? 413 GLN   A CB  1 
ATOM   1603 C CG  . GLN   A 1 217 ? -17.08200 -19.70600 -11.38400 1.000 57.00864 ? 413 GLN   A CG  1 
ATOM   1604 C CD  . GLN   A 1 217 ? -17.07800 -20.17600 -9.94100  1.000 65.92608 ? 413 GLN   A CD  1 
ATOM   1605 O OE1 . GLN   A 1 217 ? -16.02400 -20.52600 -9.39600  1.000 60.65934 ? 413 GLN   A OE1 1 
ATOM   1606 N NE2 . GLN   A 1 217 ? -18.25300 -20.16700 -9.30500  1.000 66.72146 ? 413 GLN   A NE2 1 
ATOM   1607 N N   . SER   A 1 218 ? -16.54800 -16.53400 -13.47000 1.000 49.66542 ? 414 SER   A N   1 
ATOM   1608 C CA  . SER   A 1 218 ? -17.53700 -15.58300 -13.97200 1.000 49.04212 ? 414 SER   A CA  1 
ATOM   1609 C C   . SER   A 1 218 ? -17.20400 -15.02600 -15.35100 1.000 51.32001 ? 414 SER   A C   1 
ATOM   1610 O O   . SER   A 1 218 ? -18.12100 -14.78100 -16.14000 1.000 53.87121 ? 414 SER   A O   1 
ATOM   1611 C CB  . SER   A 1 218 ? -17.71500 -14.42500 -12.99200 1.000 49.40379 ? 414 SER   A CB  1 
ATOM   1612 O OG  . SER   A 1 218 ? -16.47000 -13.90200 -12.58400 1.000 47.58384 ? 414 SER   A OG  1 
ATOM   1613 N N   . ASN   A 1 219 ? -15.92800 -14.82100 -15.68200 1.000 49.50154 ? 415 ASN   A N   1 
ATOM   1614 C CA  . ASN   A 1 219 ? -15.60700 -14.25100 -16.98900 1.000 47.33753 ? 415 ASN   A CA  1 
ATOM   1615 C C   . ASN   A 1 219 ? -15.73100 -15.25900 -18.12300 1.000 47.38711 ? 415 ASN   A C   1 
ATOM   1616 O O   . ASN   A 1 219 ? -15.91600 -14.85100 -19.27200 1.000 48.53765 ? 415 ASN   A O   1 
ATOM   1617 C CB  . ASN   A 1 219 ? -14.19800 -13.65800 -16.98200 1.000 45.18219 ? 415 ASN   A CB  1 
ATOM   1618 C CG  . ASN   A 1 219 ? -13.96900 -12.69100 -18.12100 1.000 49.08870 ? 415 ASN   A CG  1 
ATOM   1619 O OD1 . ASN   A 1 219 ? -14.86200 -11.92200 -18.49400 1.000 49.96321 ? 415 ASN   A OD1 1 
ATOM   1620 N ND2 . ASN   A 1 219 ? -12.76800 -12.73000 -18.69500 1.000 47.78549 ? 415 ASN   A ND2 1 
ATOM   1621 N N   . HIS   A 1 220 ? -15.64800 -16.55400 -17.82700 1.000 46.17374 ? 416 HIS   A N   1 
ATOM   1622 C CA  . HIS   A 1 220 ? -15.79000 -17.61800 -18.82300 1.000 48.41386 ? 416 HIS   A CA  1 
ATOM   1623 C C   . HIS   A 1 220 ? -16.71500 -18.71300 -18.30500 1.000 52.24572 ? 416 HIS   A C   1 
ATOM   1624 O O   . HIS   A 1 220 ? -16.31200 -19.87600 -18.20500 1.000 50.52774 ? 416 HIS   A O   1 
ATOM   1625 C CB  . HIS   A 1 220 ? -14.43300 -18.22200 -19.17200 1.000 49.68111 ? 416 HIS   A CB  1 
ATOM   1626 C CG  . HIS   A 1 220 ? -13.48500 -17.25600 -19.79600 1.000 46.65443 ? 416 HIS   A CG  1 
ATOM   1627 N ND1 . HIS   A 1 220 ? -13.29100 -17.18500 -21.15800 1.000 46.17777 ? 416 HIS   A ND1 1 
ATOM   1628 C CD2 . HIS   A 1 220 ? -12.64500 -16.35000 -19.24300 1.000 46.18192 ? 416 HIS   A CD2 1 
ATOM   1629 C CE1 . HIS   A 1 220 ? -12.39400 -16.24900 -21.42100 1.000 50.29776 ? 416 HIS   A CE1 1 
ATOM   1630 N NE2 . HIS   A 1 220 ? -11.98700 -15.72600 -20.27500 1.000 46.11894 ? 416 HIS   A NE2 1 
ATOM   1631 N N   . PRO   A 1 221 ? -17.97400 -18.37900 -17.98700 1.000 53.71033 ? 417 PRO   A N   1 
ATOM   1632 C CA  . PRO   A 1 221 ? -18.84900 -19.37900 -17.34300 1.000 59.26980 ? 417 PRO   A CA  1 
ATOM   1633 C C   . PRO   A 1 221 ? -19.10400 -20.59900 -18.19700 1.000 60.98474 ? 417 PRO   A C   1 
ATOM   1634 O O   . PRO   A 1 221 ? -19.48400 -21.64100 -17.65200 1.000 69.68405 ? 417 PRO   A O   1 
ATOM   1635 C CB  . PRO   A 1 221 ? -20.15000 -18.60400 -17.07300 1.000 57.54074 ? 417 PRO   A CB  1 
ATOM   1636 C CG  . PRO   A 1 221 ? -19.82100 -17.15500 -17.30500 1.000 55.48078 ? 417 PRO   A CG  1 
ATOM   1637 C CD  . PRO   A 1 221 ? -18.69600 -17.13500 -18.29300 1.000 57.16141 ? 417 PRO   A CD  1 
ATOM   1638 N N   . ASP   A 1 222 ? -18.87200 -20.52000 -19.50800 1.000 56.37462 ? 418 ASP   A N   1 
ATOM   1639 C CA  . ASP   A 1 222 ? -19.14700 -21.63800 -20.39900 1.000 62.70932 ? 418 ASP   A CA  1 
ATOM   1640 C C   . ASP   A 1 222 ? -18.00900 -22.64600 -20.48100 1.000 64.31841 ? 418 ASP   A C   1 
ATOM   1641 O O   . ASP   A 1 222 ? -18.25900 -23.80100 -20.83500 1.000 71.37956 ? 418 ASP   A O   1 
ATOM   1642 C CB  . ASP   A 1 222 ? -19.45500 -21.12600 -21.81100 1.000 69.93495 ? 418 ASP   A CB  1 
ATOM   1643 C CG  . ASP   A 1 222 ? -20.89800 -20.64400 -21.97000 1.000 76.95273 ? 418 ASP   A CG  1 
ATOM   1644 O OD1 . ASP   A 1 222 ? -21.15100 -19.81900 -22.88100 1.000 73.39560 ? 418 ASP   A OD1 1 
ATOM   1645 O OD2 . ASP   A 1 222 ? -21.77600 -21.07300 -21.18400 1.000 76.73662 ? 418 ASP   A OD2 1 
ATOM   1646 N N   . ASP   A 1 223 ? -16.76800 -22.25100 -20.18700 1.000 61.59872 ? 419 ASP   A N   1 
ATOM   1647 C CA  . ASP   A 1 223 ? -15.63900 -23.18800 -20.19100 1.000 59.87208 ? 419 ASP   A CA  1 
ATOM   1648 C C   . ASP   A 1 223 ? -15.30400 -23.51900 -18.74200 1.000 58.81187 ? 419 ASP   A C   1 
ATOM   1649 O O   . ASP   A 1 223 ? -14.47200 -22.86700 -18.10500 1.000 55.30644 ? 419 ASP   A O   1 
ATOM   1650 C CB  . ASP   A 1 223 ? -14.42700 -22.63500 -20.93400 1.000 54.13553 ? 419 ASP   A CB  1 
ATOM   1651 C CG  . ASP   A 1 223 ? -13.34500 -23.70400 -21.16200 1.000 60.56641 ? 419 ASP   A CG  1 
ATOM   1652 O OD1 . ASP   A 1 223 ? -13.39900 -24.78900 -20.52200 1.000 60.22935 ? 419 ASP   A OD1 1 
ATOM   1653 O OD2 . ASP   A 1 223 ? -12.43000 -23.46500 -21.97800 1.000 61.96032 ? 419 ASP   A OD2 1 
ATOM   1654 N N   . ILE   A 1 224 ? -15.94200 -24.57700 -18.23400 1.000 56.92447 ? 420 ILE   A N   1 
ATOM   1655 C CA  . ILE   A 1 224 ? -15.82300 -24.93900 -16.82900 1.000 57.97091 ? 420 ILE   A CA  1 
ATOM   1656 C C   . ILE   A 1 224 ? -14.47200 -25.54600 -16.49600 1.000 55.47385 ? 420 ILE   A C   1 
ATOM   1657 O O   . ILE   A 1 224 ? -14.12500 -25.65300 -15.31500 1.000 56.16059 ? 420 ILE   A O   1 
ATOM   1658 C CB  . ILE   A 1 224 ? -16.93900 -25.92500 -16.45000 1.000 64.17950 ? 420 ILE   A CB  1 
ATOM   1659 C CG1 . ILE   A 1 224 ? -16.87900 -27.13700 -17.37900 1.000 57.77378 ? 420 ILE   A CG1 1 
ATOM   1660 C CG2 . ILE   A 1 224 ? -18.29600 -25.23500 -16.50900 1.000 69.00594 ? 420 ILE   A CG2 1 
ATOM   1661 C CD1 . ILE   A 1 224 ? -18.15600 -27.94400 -17.43100 1.000 69.28117 ? 420 ILE   A CD1 1 
ATOM   1662 N N   . PHE   A 1 225 ? -13.71700 -25.98100 -17.49900 1.000 50.31646 ? 421 PHE   A N   1 
ATOM   1663 C CA  . PHE   A 1 225 ? -12.41700 -26.60200 -17.30400 1.000 49.58478 ? 421 PHE   A CA  1 
ATOM   1664 C C   . PHE   A 1 225 ? -11.26300 -25.63600 -17.57500 1.000 50.43721 ? 421 PHE   A C   1 
ATOM   1665 O O   . PHE   A 1 225 ? -10.10400 -26.06400 -17.63500 1.000 44.75765 ? 421 PHE   A O   1 
ATOM   1666 C CB  . PHE   A 1 225 ? -12.30200 -27.82800 -18.20500 1.000 53.97612 ? 421 PHE   A CB  1 
ATOM   1667 C CG  . PHE   A 1 225 ? -12.91900 -29.06600 -17.62000 1.000 60.39909 ? 421 PHE   A CG  1 
ATOM   1668 C CD1 . PHE   A 1 225 ? -13.89100 -29.76500 -18.31400 1.000 65.35761 ? 421 PHE   A CD1 1 
ATOM   1669 C CD2 . PHE   A 1 225 ? -12.52800 -29.52800 -16.37200 1.000 61.78826 ? 421 PHE   A CD2 1 
ATOM   1670 C CE1 . PHE   A 1 225 ? -14.46100 -30.91000 -17.77300 1.000 65.18819 ? 421 PHE   A CE1 1 
ATOM   1671 C CE2 . PHE   A 1 225 ? -13.08700 -30.67300 -15.82700 1.000 67.69932 ? 421 PHE   A CE2 1 
ATOM   1672 C CZ  . PHE   A 1 225 ? -14.05500 -31.36500 -16.52800 1.000 68.90088 ? 421 PHE   A CZ  1 
ATOM   1673 N N   . LEU   A 1 226 ? -11.55700 -24.34400 -17.73100 1.000 45.24609 ? 422 LEU   A N   1 
ATOM   1674 C CA  . LEU   A 1 226 ? -10.52500 -23.38400 -18.10900 1.000 44.59702 ? 422 LEU   A CA  1 
ATOM   1675 C C   . LEU   A 1 226 ? -9.41500  -23.31000 -17.06600 1.000 39.93980 ? 422 LEU   A C   1 
ATOM   1676 O O   . LEU   A 1 226 ? -8.23100  -23.25500 -17.41700 1.000 39.63542 ? 422 LEU   A O   1 
ATOM   1677 C CB  . LEU   A 1 226 ? -11.14900 -22.00600 -18.32400 1.000 42.94511 ? 422 LEU   A CB  1 
ATOM   1678 C CG  . LEU   A 1 226 ? -10.18800 -20.92300 -18.81800 1.000 43.79460 ? 422 LEU   A CG  1 
ATOM   1679 C CD1 . LEU   A 1 226 ? -9.25100  -21.48400 -19.88100 1.000 41.53311 ? 422 LEU   A CD1 1 
ATOM   1680 C CD2 . LEU   A 1 226 ? -10.94800 -19.69300 -19.35400 1.000 43.51258 ? 422 LEU   A CD2 1 
ATOM   1681 N N   . PHE   A 1 227 ? -9.76900  -23.34300 -15.78300 1.000 35.47274 ? 423 PHE   A N   1 
ATOM   1682 C CA  . PHE   A 1 227 ? -8.74600  -23.14900 -14.75300 1.000 40.50675 ? 423 PHE   A CA  1 
ATOM   1683 C C   . PHE   A 1 227 ? -7.66600  -24.22600 -14.79000 1.000 37.69419 ? 423 PHE   A C   1 
ATOM   1684 O O   . PHE   A 1 227 ? -6.47700  -23.86600 -14.84300 1.000 33.71311 ? 423 PHE   A O   1 
ATOM   1685 C CB  . PHE   A 1 227 ? -9.39400  -23.03300 -13.36900 1.000 39.92111 ? 423 PHE   A CB  1 
ATOM   1686 C CG  . PHE   A 1 227 ? -8.39400  -22.90700 -12.25500 1.000 42.45889 ? 423 PHE   A CG  1 
ATOM   1687 C CD1 . PHE   A 1 227 ? -7.46900  -21.86300 -12.24500 1.000 37.39481 ? 423 PHE   A CD1 1 
ATOM   1688 C CD2 . PHE   A 1 227 ? -8.35700  -23.83700 -11.22900 1.000 42.55837 ? 423 PHE   A CD2 1 
ATOM   1689 C CE1 . PHE   A 1 227 ? -6.52000  -21.75900 -11.21800 1.000 35.03361 ? 423 PHE   A CE1 1 
ATOM   1690 C CE2 . PHE   A 1 227 ? -7.42400  -23.73300 -10.20200 1.000 43.06975 ? 423 PHE   A CE2 1 
ATOM   1691 C CZ  . PHE   A 1 227 ? -6.50500  -22.69400 -10.19900 1.000 40.76430 ? 423 PHE   A CZ  1 
ATOM   1692 N N   . PRO   A 1 228 ? -7.96800  -25.53000 -14.79800 1.000 39.29342 ? 424 PRO   A N   1 
ATOM   1693 C CA  . PRO   A 1 228 ? -6.86100  -26.50000 -14.88200 1.000 37.82994 ? 424 PRO   A CA  1 
ATOM   1694 C C   . PRO   A 1 228 ? -6.14900  -26.48800 -16.23600 1.000 35.33258 ? 424 PRO   A C   1 
ATOM   1695 O O   . PRO   A 1 228 ? -4.94100  -26.77000 -16.29600 1.000 34.91777 ? 424 PRO   A O   1 
ATOM   1696 C CB  . PRO   A 1 228 ? -7.53800  -27.84800 -14.57400 1.000 41.25336 ? 424 PRO   A CB  1 
ATOM   1697 C CG  . PRO   A 1 228 ? -8.97800  -27.63800 -14.83500 1.000 39.64844 ? 424 PRO   A CG  1 
ATOM   1698 C CD  . PRO   A 1 228 ? -9.25900  -26.19300 -14.52000 1.000 39.01154 ? 424 PRO   A CD  1 
ATOM   1699 N N   . LYS   A 1 229 ? -6.83900  -26.12800 -17.32000 1.000 34.86579 ? 425 LYS   A N   1 
ATOM   1700 C CA  . LYS   A 1 229 ? -6.14900  -25.94300 -18.59500 1.000 31.36125 ? 425 LYS   A CA  1 
ATOM   1701 C C   . LYS   A 1 229 ? -5.07500  -24.86900 -18.48200 1.000 33.66414 ? 425 LYS   A C   1 
ATOM   1702 O O   . LYS   A 1 229 ? -3.96800  -25.02500 -19.00500 1.000 31.57763 ? 425 LYS   A O   1 
ATOM   1703 C CB  . LYS   A 1 229 ? -7.14000  -25.54200 -19.68900 1.000 38.25508 ? 425 LYS   A CB  1 
ATOM   1704 C CG  . LYS   A 1 229 ? -8.02700  -26.64100 -20.22600 1.000 47.21730 ? 425 LYS   A CG  1 
ATOM   1705 C CD  . LYS   A 1 229 ? -9.01500  -26.05400 -21.24500 1.000 50.40729 ? 425 LYS   A CD  1 
ATOM   1706 C CE  . LYS   A 1 229 ? -10.02000 -27.09700 -21.72000 1.000 55.55649 ? 425 LYS   A CE  1 
ATOM   1707 N NZ  . LYS   A 1 229 ? -11.12100 -26.48500 -22.52000 1.000 58.53532 ? 425 LYS   A NZ  1 
ATOM   1708 N N   . LEU   A 1 230 ? -5.39000  -23.76400 -17.80000 1.000 33.45800 ? 426 LEU   A N   1 
ATOM   1709 C CA  . LEU   A 1 230 ? -4.43000  -22.67800 -17.65200 1.000 33.41116 ? 426 LEU   A CA  1 
ATOM   1710 C C   . LEU   A 1 230 ? -3.27900  -23.07500 -16.73400 1.000 33.34444 ? 426 LEU   A C   1 
ATOM   1711 O O   . LEU   A 1 230 ? -2.12700  -22.69700 -16.97100 1.000 35.19123 ? 426 LEU   A O   1 
ATOM   1712 C CB  . LEU   A 1 230 ? -5.13700  -21.44300 -17.09600 1.000 38.54374 ? 426 LEU   A CB  1 
ATOM   1713 C CG  . LEU   A 1 230 ? -5.59400  -20.35800 -18.04400 1.000 43.45568 ? 426 LEU   A CG  1 
ATOM   1714 C CD1 . LEU   A 1 230 ? -5.89300  -19.08000 -17.21700 1.000 37.25370 ? 426 LEU   A CD1 1 
ATOM   1715 C CD2 . LEU   A 1 230 ? -4.51400  -20.10600 -19.09300 1.000 41.85118 ? 426 LEU   A CD2 1 
ATOM   1716 N N   . LEU   A 1 231 ? -3.56800  -23.84200 -15.68100 1.000 36.31377 ? 427 LEU   A N   1 
ATOM   1717 C CA  . LEU   A 1 231 ? -2.49400  -24.37300 -14.84900 1.000 35.59592 ? 427 LEU   A CA  1 
ATOM   1718 C C   . LEU   A 1 231 ? -1.49900  -25.17600 -15.68300 1.000 34.70460 ? 427 LEU   A C   1 
ATOM   1719 O O   . LEU   A 1 231 ? -0.27800  -25.01800 -15.53800 1.000 37.89330 ? 427 LEU   A O   1 
ATOM   1720 C CB  . LEU   A 1 231 ? -3.07800  -25.22900 -13.72100 1.000 35.91577 ? 427 LEU   A CB  1 
ATOM   1721 C CG  . LEU   A 1 231 ? -3.89200  -24.51300 -12.63400 1.000 39.18645 ? 427 LEU   A CG  1 
ATOM   1722 C CD1 . LEU   A 1 231 ? -4.43800  -25.53000 -11.60300 1.000 40.89630 ? 427 LEU   A CD1 1 
ATOM   1723 C CD2 . LEU   A 1 231 ? -3.03400  -23.46900 -11.91500 1.000 38.19796 ? 427 LEU   A CD2 1 
ATOM   1724 N N   . GLN   A 1 232 ? -1.99700  -26.05600 -16.55100 1.000 33.79226 ? 428 GLN   A N   1 
ATOM   1725 C CA  . GLN   A 1 232 ? -1.10400  -26.77700 -17.45500 1.000 33.61938 ? 428 GLN   A CA  1 
ATOM   1726 C C   . GLN   A 1 232 ? -0.35500  -25.82900 -18.39500 1.000 39.82467 ? 428 GLN   A C   1 
ATOM   1727 O O   . GLN   A 1 232 ? 0.82000   -26.07000 -18.71500 1.000 34.31856 ? 428 GLN   A O   1 
ATOM   1728 C CB  . GLN   A 1 232 ? -1.89800  -27.81400 -18.25800 1.000 36.36448 ? 428 GLN   A CB  1 
ATOM   1729 C CG  . GLN   A 1 232 ? -1.06200  -28.54200 -19.29700 1.000 38.92369 ? 428 GLN   A CG  1 
ATOM   1730 C CD  . GLN   A 1 232 ? -1.85300  -29.52700 -20.13100 1.000 41.27069 ? 428 GLN   A CD  1 
ATOM   1731 O OE1 . GLN   A 1 232 ? -2.72100  -29.14800 -20.92400 1.000 46.85049 ? 428 GLN   A OE1 1 
ATOM   1732 N NE2 . GLN   A 1 232 ? -1.54500  -30.80200 -19.97000 1.000 45.14953 ? 428 GLN   A NE2 1 
ATOM   1733 N N   . LYS   A 1 233 ? -1.00000  -24.74100 -18.84800 1.000 32.88078 ? 429 LYS   A N   1 
ATOM   1734 C CA  . LYS   A 1 233 ? -0.27500  -23.81000 -19.70300 1.000 37.83736 ? 429 LYS   A CA  1 
ATOM   1735 C C   . LYS   A 1 233 ? 0.92800   -23.22000 -18.97900 1.000 37.09789 ? 429 LYS   A C   1 
ATOM   1736 O O   . LYS   A 1 233 ? 1.96100   -22.97600 -19.60300 1.000 34.75676 ? 429 LYS   A O   1 
ATOM   1737 C CB  . LYS   A 1 233 ? -1.20100  -22.70000 -20.22200 1.000 36.59988 ? 429 LYS   A CB  1 
ATOM   1738 C CG  . LYS   A 1 233 ? -2.31000  -23.22400 -21.16500 1.000 40.21472 ? 429 LYS   A CG  1 
ATOM   1739 C CD  . LYS   A 1 233 ? -1.75500  -23.71500 -22.51300 1.000 35.88627 ? 429 LYS   A CD  1 
ATOM   1740 C CE  . LYS   A 1 233 ? -2.90400  -24.18300 -23.42800 1.000 42.72242 ? 429 LYS   A CE  1 
ATOM   1741 N NZ  . LYS   A 1 233 ? -2.50600  -25.32500 -24.31700 1.000 45.61301 ? 429 LYS   A NZ  1 
ATOM   1742 N N   . MET   A 1 234 ? 0.83800   -23.00900 -17.66800 1.000 33.41859 ? 430 MET   A N   1 
ATOM   1743 C CA  . MET   A 1 234 ? 2.02300   -22.54400 -16.95400 1.000 35.48038 ? 430 MET   A CA  1 
ATOM   1744 C C   . MET   A 1 234 ? 3.15000   -23.57500 -17.00200 1.000 40.09613 ? 430 MET   A C   1 
ATOM   1745 O O   . MET   A 1 234 ? 4.32600   -23.21500 -17.11700 1.000 37.89399 ? 430 MET   A O   1 
ATOM   1746 C CB  . MET   A 1 234 ? 1.68900   -22.20200 -15.50200 1.000 41.12984 ? 430 MET   A CB  1 
ATOM   1747 C CG  . MET   A 1 234 ? 0.66800   -21.07600 -15.29900 1.000 40.29580 ? 430 MET   A CG  1 
ATOM   1748 S SD  . MET   A 1 234 ? 0.16700   -20.99500 -13.55700 1.000 51.45263 ? 430 MET   A SD  1 
ATOM   1749 C CE  . MET   A 1 234 ? 1.73200   -20.52000 -12.82000 1.000 47.41756 ? 430 MET   A CE  1 
ATOM   1750 N N   . ALA   A 1 235 ? 2.82100   -24.86300 -16.90300 1.000 37.47103 ? 431 ALA   A N   1 
ATOM   1751 C CA  . ALA   A 1 235 ? 3.86500   -25.87600 -17.03800 1.000 40.28692 ? 431 ALA   A CA  1 
ATOM   1752 C C   . ALA   A 1 235 ? 4.42500   -25.89500 -18.45900 1.000 37.17486 ? 431 ALA   A C   1 
ATOM   1753 O O   . ALA   A 1 235 ? 5.63300   -26.05000 -18.65300 1.000 38.83419 ? 431 ALA   A O   1 
ATOM   1754 C CB  . ALA   A 1 235 ? 3.31800   -27.25400 -16.64100 1.000 41.35972 ? 431 ALA   A CB  1 
ATOM   1755 N N   . ASP   A 1 236 ? 3.56100   -25.74000 -19.46700 1.000 36.69164 ? 432 ASP   A N   1 
ATOM   1756 C CA  . ASP   A 1 236 ? 4.04000   -25.67700 -20.84300 1.000 34.68982 ? 432 ASP   A CA  1 
ATOM   1757 C C   . ASP   A 1 236 ? 4.99000   -24.50100 -21.04200 1.000 35.94903 ? 432 ASP   A C   1 
ATOM   1758 O O   . ASP   A 1 236 ? 5.98800   -24.61200 -21.76300 1.000 37.53864 ? 432 ASP   A O   1 
ATOM   1759 C CB  . ASP   A 1 236 ? 2.87000   -25.57000 -21.81900 1.000 37.58173 ? 432 ASP   A CB  1 
ATOM   1760 C CG  . ASP   A 1 236 ? 1.94400   -26.77600 -21.78000 1.000 47.73717 ? 432 ASP   A CG  1 
ATOM   1761 O OD1 . ASP   A 1 236 ? 0.81700   -26.67200 -22.31100 1.000 50.80351 ? 432 ASP   A OD1 1 
ATOM   1762 O OD2 . ASP   A 1 236 ? 2.31800   -27.82100 -21.22100 1.000 47.02180 ? 432 ASP   A OD2 1 
ATOM   1763 N N   . LEU   A 1 237 ? 4.70500   -23.36200 -20.40700 1.000 34.61831 ? 433 LEU   A N   1 
ATOM   1764 C CA  . LEU   A 1 237 ? 5.57300   -22.20000 -20.59000 1.000 34.20650 ? 433 LEU   A CA  1 
ATOM   1765 C C   . LEU   A 1 237 ? 6.95000   -22.45000 -19.98500 1.000 39.27866 ? 433 LEU   A C   1 
ATOM   1766 O O   . LEU   A 1 237 ? 7.97300   -22.04500 -20.56200 1.000 36.24592 ? 433 LEU   A O   1 
ATOM   1767 C CB  . LEU   A 1 237 ? 4.92700   -20.96200 -19.96200 1.000 33.59495 ? 433 LEU   A CB  1 
ATOM   1768 C CG  . LEU   A 1 237 ? 3.91400   -20.27600 -20.85900 1.000 32.88779 ? 433 LEU   A CG  1 
ATOM   1769 C CD1 . LEU   A 1 237 ? 3.08200   -19.30700 -20.03300 1.000 34.29865 ? 433 LEU   A CD1 1 
ATOM   1770 C CD2 . LEU   A 1 237 ? 4.62900   -19.55800 -22.00300 1.000 35.82265 ? 433 LEU   A CD2 1 
ATOM   1771 N N   . ARG   A 1 238 ? 7.01000   -23.12500 -18.85100 1.000 39.30694 ? 434 ARG   A N   1 
ATOM   1772 C CA  . ARG   A 1 238 ? 8.28600   -23.44400 -18.24600 1.000 40.11273 ? 434 ARG   A CA  1 
ATOM   1773 C C   . ARG   A 1 238 ? 9.14300   -24.26200 -19.19400 1.000 41.08862 ? 434 ARG   A C   1 
ATOM   1774 O O   . ARG   A 1 238 ? 10.29100  -23.98900 -19.36000 1.000 43.71636 ? 434 ARG   A O   1 
ATOM   1775 C CB  . ARG   A 1 238 ? 8.10300   -24.20000 -16.95100 1.000 47.78387 ? 434 ARG   A CB  1 
ATOM   1776 C CG  . ARG   A 1 238 ? 9.22200   -24.01600 -15.95400 1.000 49.31370 ? 434 ARG   A CG  1 
ATOM   1777 C CD  . ARG   A 1 238 ? 8.88900   -24.65200 -14.62700 1.000 47.15962 ? 434 ARG   A CD  1 
ATOM   1778 N NE  . ARG   A 1 238 ? 8.29800   -23.70400 -13.71600 1.000 53.15533 ? 434 ARG   A NE  1 
ATOM   1779 C CZ  . ARG   A 1 238 ? 7.94800   -23.97200 -12.46800 1.000 54.38104 ? 434 ARG   A CZ  1 
ATOM   1780 N NH1 . ARG   A 1 238 ? 8.12800   -25.16900 -11.97000 1.000 57.51056 ? 434 ARG   A NH1 1 
ATOM   1781 N NH2 . ARG   A 1 238 ? 7.40500   -23.04800 -11.72100 1.000 53.13953 ? 434 ARG   A NH2 1 
ATOM   1782 N N   . GLN   A 1 239 ? 8.55200   -25.25800 -19.82400 1.000 42.71159 ? 435 GLN   A N   1 
ATOM   1783 C CA  . GLN   A 1 239 ? 9.26900   -26.10000 -20.76500 1.000 44.77018 ? 435 GLN   A CA  1 
ATOM   1784 C C   . GLN   A 1 239 ? 9.67000   -25.27400 -21.96300 1.000 47.97713 ? 435 GLN   A C   1 
ATOM   1785 O O   . GLN   A 1 239 ? 10.77200  -25.38100 -22.43600 1.000 44.83694 ? 435 GLN   A O   1 
ATOM   1786 C CB  . GLN   A 1 239 ? 8.41800   -27.28900 -21.19000 1.000 45.88663 ? 435 GLN   A CB  1 
ATOM   1787 C CG  . GLN   A 1 239 ? 9.17500   -28.44700 -21.80600 1.000 49.05021 ? 435 GLN   A CG  1 
ATOM   1788 C CD  . GLN   A 1 239 ? 10.58400  -28.62700 -21.26500 1.000 59.62131 ? 435 GLN   A CD  1 
ATOM   1789 O OE1 . GLN   A 1 239 ? 10.81800  -28.56400 -20.06700 1.000 62.27376 ? 435 GLN   A OE1 1 
ATOM   1790 N NE2 . GLN   A 1 239 ? 11.52200  -28.86000 -22.15400 1.000 58.64075 ? 435 GLN   A NE2 1 
ATOM   1791 N N   . LEU   A 1 240 ? 8.76300   -24.43100 -22.42800 1.000 40.69306 ? 436 LEU   A N   1 
ATOM   1792 C CA  . LEU   A 1 240 ? 9.04100   -23.57700 -23.54600 1.000 40.00506 ? 436 LEU   A CA  1 
ATOM   1793 C C   . LEU   A 1 240 ? 10.27300  -22.72100 -23.29300 1.000 40.66719 ? 436 LEU   A C   1 
ATOM   1794 O O   . LEU   A 1 240 ? 11.08500  -22.55700 -24.15200 1.000 41.26239 ? 436 LEU   A O   1 
ATOM   1795 C CB  . LEU   A 1 240 ? 7.84300   -22.69200 -23.85500 1.000 38.73048 ? 436 LEU   A CB  1 
ATOM   1796 C CG  . LEU   A 1 240 ? 7.91400   -21.89100 -25.12900 1.000 40.58413 ? 436 LEU   A CG  1 
ATOM   1797 C CD1 . LEU   A 1 240 ? 7.85100   -22.83000 -26.29600 1.000 41.22648 ? 436 LEU   A CD1 1 
ATOM   1798 C CD2 . LEU   A 1 240 ? 6.76900   -20.92100 -25.21300 1.000 42.13189 ? 436 LEU   A CD2 1 
ATOM   1799 N N   . VAL   A 1 241 ? 10.37700  -22.15700 -22.10800 1.000 38.20733 ? 437 VAL   A N   1 
ATOM   1800 C CA  . VAL   A 1 241 ? 11.52900  -21.32700 -21.77500 1.000 39.92439 ? 437 VAL   A CA  1 
ATOM   1801 C C   . VAL   A 1 241 ? 12.78200  -22.18700 -21.63800 1.000 44.26862 ? 437 VAL   A C   1 
ATOM   1802 O O   . VAL   A 1 241 ? 13.88500  -21.75200 -21.98600 1.000 43.70520 ? 437 VAL   A O   1 
ATOM   1803 C CB  . VAL   A 1 241 ? 11.24100  -20.50800 -20.50400 1.000 40.05273 ? 437 VAL   A CB  1 
ATOM   1804 C CG1 . VAL   A 1 241 ? 12.50800  -19.85700 -19.96900 1.000 36.55235 ? 437 VAL   A CG1 1 
ATOM   1805 C CG2 . VAL   A 1 241 ? 10.18200  -19.42200 -20.80400 1.000 40.10066 ? 437 VAL   A CG2 1 
ATOM   1806 N N   . THR   A 1 242 ? 12.64000  -23.42300 -21.14700 1.000 45.38094 ? 438 THR   A N   1 
ATOM   1807 C CA  . THR   A 1 242 ? 13.79800  -24.30900 -21.07600 1.000 46.27638 ? 438 THR   A CA  1 
ATOM   1808 C C   . THR   A 1 242 ? 14.37600  -24.53300 -22.46000 1.000 47.17121 ? 438 THR   A C   1 
ATOM   1809 O O   . THR   A 1 242 ? 15.57800  -24.35400 -22.67800 1.000 49.82927 ? 438 THR   A O   1 
ATOM   1810 C CB  . THR   A 1 242 ? 13.42100  -25.63400 -20.42800 1.000 46.86168 ? 438 THR   A CB  1 
ATOM   1811 O OG1 . THR   A 1 242 ? 13.05300  -25.39300 -19.06500 1.000 50.35951 ? 438 THR   A OG1 1 
ATOM   1812 C CG2 . THR   A 1 242 ? 14.61800  -26.58500 -20.46900 1.000 51.13359 ? 438 THR   A CG2 1 
ATOM   1813 N N   . GLU   A 1 243 ? 13.51300  -24.85200 -23.42800 1.000 45.52932 ? 439 GLU   A N   1 
ATOM   1814 C CA  . GLU   A 1 243 ? 13.97200  -25.03600 -24.79400 1.000 48.03616 ? 439 GLU   A CA  1 
ATOM   1815 C C   . GLU   A 1 243 ? 14.51800  -23.73800 -25.37800 1.000 51.85841 ? 439 GLU   A C   1 
ATOM   1816 O O   . GLU   A 1 243 ? 15.52800  -23.75400 -26.08800 1.000 51.67625 ? 439 GLU   A O   1 
ATOM   1817 C CB  . GLU   A 1 243 ? 12.83600  -25.60200 -25.64300 1.000 48.93204 ? 439 GLU   A CB  1 
ATOM   1818 C CG  . GLU   A 1 243 ? 12.52000  -27.06900 -25.28600 1.000 54.54442 ? 439 GLU   A CG  1 
ATOM   1819 C CD  . GLU   A 1 243 ? 11.03800  -27.43400 -25.42600 1.000 59.85864 ? 439 GLU   A CD  1 
ATOM   1820 O OE1 . GLU   A 1 243 ? 10.71000  -28.64500 -25.43000 1.000 59.25623 ? 439 GLU   A OE1 1 
ATOM   1821 O OE2 . GLU   A 1 243 ? 10.19900  -26.50900 -25.52400 1.000 63.92734 ? 439 GLU   A OE2 1 
ATOM   1822 N N   . HIS   A 1 244 ? 13.88500  -22.59700 -25.07000 1.000 49.06788 ? 440 HIS   A N   1 
ATOM   1823 C CA  . HIS   A 1 244 ? 14.34200  -21.33400 -25.65200 1.000 48.52241 ? 440 HIS   A CA  1 
ATOM   1824 C C   . HIS   A 1 244 ? 15.73600  -20.98000 -25.16100 1.000 47.20104 ? 440 HIS   A C   1 
ATOM   1825 O O   . HIS   A 1 244 ? 16.55600  -20.45800 -25.92600 1.000 47.84536 ? 440 HIS   A O   1 
ATOM   1826 C CB  . HIS   A 1 244 ? 13.36000  -20.19900 -25.32800 1.000 45.13114 ? 440 HIS   A CB  1 
ATOM   1827 C CG  . HIS   A 1 244 ? 13.81700  -18.84400 -25.79300 1.000 44.22232 ? 440 HIS   A CG  1 
ATOM   1828 N ND1 . HIS   A 1 244 ? 13.58700  -18.37700 -27.07100 1.000 39.49918 ? 440 HIS   A ND1 1 
ATOM   1829 C CD2 . HIS   A 1 244 ? 14.47200  -17.85000 -25.14100 1.000 40.07577 ? 440 HIS   A CD2 1 
ATOM   1830 C CE1 . HIS   A 1 244 ? 14.08300  -17.15500 -27.18800 1.000 40.20720 ? 440 HIS   A CE1 1 
ATOM   1831 N NE2 . HIS   A 1 244 ? 14.62300  -16.81300 -26.03100 1.000 42.14049 ? 440 HIS   A NE2 1 
ATOM   1832 N N   . ALA   A 1 245 ? 16.01900  -21.25200 -23.88600 1.000 46.27197 ? 441 ALA   A N   1 
ATOM   1833 C CA  . ALA   A 1 245 ? 17.35100  -20.98900 -23.35000 1.000 48.94021 ? 441 ALA   A CA  1 
ATOM   1834 C C   . ALA   A 1 245 ? 18.42300  -21.77400 -24.10300 1.000 56.03767 ? 441 ALA   A C   1 
ATOM   1835 O O   . ALA   A 1 245 ? 19.54900  -21.28800 -24.26500 1.000 56.39304 ? 441 ALA   A O   1 
ATOM   1836 C CB  . ALA   A 1 245 ? 17.39900  -21.32500 -21.85800 1.000 44.48567 ? 441 ALA   A CB  1 
ATOM   1837 N N   . GLN   A 1 246 ? 18.09500  -22.98100 -24.57400 1.000 50.63031 ? 442 GLN   A N   1 
ATOM   1838 C CA  . GLN   A 1 246 ? 19.06700  -23.73000 -25.36000 1.000 55.51347 ? 442 GLN   A CA  1 
ATOM   1839 C C   . GLN   A 1 246 ? 19.36500  -23.03600 -26.68200 1.000 59.63146 ? 442 GLN   A C   1 
ATOM   1840 O O   . GLN   A 1 246 ? 20.48100  -23.14800 -27.20300 1.000 58.96106 ? 442 GLN   A O   1 
ATOM   1841 C CB  . GLN   A 1 246 ? 18.56900  -25.15000 -25.60300 1.000 55.26099 ? 442 GLN   A CB  1 
ATOM   1842 C CG  . GLN   A 1 246 ? 19.05200  -26.13500 -24.56500 1.000 59.21178 ? 442 GLN   A CG  1 
ATOM   1843 C CD  . GLN   A 1 246 ? 17.95500  -27.05700 -24.08500 1.000 66.14939 ? 442 GLN   A CD  1 
ATOM   1844 O OE1 . GLN   A 1 246 ? 17.13500  -27.52900 -24.88000 1.000 68.82040 ? 442 GLN   A OE1 1 
ATOM   1845 N NE2 . GLN   A 1 246 ? 17.94600  -27.34500 -22.78100 1.000 65.43722 ? 442 GLN   A NE2 1 
ATOM   1846 N N   . LEU   A 1 247 ? 18.39300  -22.30900 -27.23500 1.000 54.63255 ? 443 LEU   A N   1 
ATOM   1847 C CA  . LEU   A 1 247 ? 18.67300  -21.52100 -28.43000 1.000 53.19785 ? 443 LEU   A CA  1 
ATOM   1848 C C   . LEU   A 1 247 ? 19.56300  -20.32900 -28.10700 1.000 53.56694 ? 443 LEU   A C   1 
ATOM   1849 O O   . LEU   A 1 247 ? 20.42100  -19.96000 -28.91200 1.000 56.65659 ? 443 LEU   A O   1 
ATOM   1850 C CB  . LEU   A 1 247 ? 17.36800  -21.07200 -29.07400 1.000 56.20662 ? 443 LEU   A CB  1 
ATOM   1851 C CG  . LEU   A 1 247 ? 16.54400  -22.22000 -29.65200 1.000 54.14470 ? 443 LEU   A CG  1 
ATOM   1852 C CD1 . LEU   A 1 247 ? 15.06600  -21.85300 -29.68800 1.000 54.97555 ? 443 LEU   A CD1 1 
ATOM   1853 C CD2 . LEU   A 1 247 ? 17.04800  -22.55900 -31.03700 1.000 57.29008 ? 443 LEU   A CD2 1 
ATOM   1854 N N   . VAL   A 1 248 ? 19.40600  -19.77500 -26.92600 1.000 56.41445 ? 444 VAL   A N   1 
ATOM   1855 C CA  . VAL   A 1 248 ? 20.22000  -18.66800 -26.53500 1.000 54.43063 ? 444 VAL   A CA  1 
ATOM   1856 C C   . VAL   A 1 248 ? 21.67700  -19.07400 -26.39300 1.000 61.92557 ? 444 VAL   A C   1 
ATOM   1857 O O   . VAL   A 1 248 ? 22.54500  -18.27800 -26.62900 1.000 62.42485 ? 444 VAL   A O   1 
ATOM   1858 C CB  . VAL   A 1 248 ? 19.75200  -18.07900 -25.22200 1.000 56.27522 ? 444 VAL   A CB  1 
ATOM   1859 C CG1 . VAL   A 1 248 ? 20.64900  -16.94200 -24.82400 1.000 56.45834 ? 444 VAL   A CG1 1 
ATOM   1860 C CG2 . VAL   A 1 248 ? 18.32900  -17.58800 -25.33200 1.000 53.71099 ? 444 VAL   A CG2 1 
ATOM   1861 N N   . GLN   A 1 249 ? 21.94900  -20.29900 -25.98300 1.000 60.90175 ? 445 GLN   A N   1 
ATOM   1862 C CA  . GLN   A 1 249 ? 23.33100  -20.71700 -25.83800 1.000 64.35617 ? 445 GLN   A CA  1 
ATOM   1863 C C   . GLN   A 1 249 ? 23.95700  -20.86700 -27.19900 1.000 62.26037 ? 445 GLN   A C   1 
ATOM   1864 O O   . GLN   A 1 249 ? 25.06600  -20.46400 -27.41100 1.000 65.77681 ? 445 GLN   A O   1 
ATOM   1865 C CB  . GLN   A 1 249 ? 23.46900  -22.01500 -25.06400 1.000 63.02629 ? 445 GLN   A CB  1 
ATOM   1866 C CG  . GLN   A 1 249 ? 22.93800  -21.98400 -23.65300 1.000 67.33517 ? 445 GLN   A CG  1 
ATOM   1867 C CD  . GLN   A 1 249 ? 23.51900  -20.88900 -22.79000 1.000 75.24462 ? 445 GLN   A CD  1 
ATOM   1868 O OE1 . GLN   A 1 249 ? 24.67700  -20.53300 -22.91200 1.000 76.23709 ? 445 GLN   A OE1 1 
ATOM   1869 N NE2 . GLN   A 1 249 ? 22.70300  -20.36000 -21.89300 1.000 73.31249 ? 445 GLN   A NE2 1 
ATOM   1870 N N   . ILE   A 1 250 ? 23.22400  -21.45300 -28.11900 1.000 58.44712 ? 446 ILE   A N   1 
ATOM   1871 C CA  . ILE   A 1 250 ? 23.70700  -21.62200 -29.45600 1.000 58.46776 ? 446 ILE   A CA  1 
ATOM   1872 C C   . ILE   A 1 250 ? 24.05900  -20.28800 -30.05500 1.000 63.07943 ? 446 ILE   A C   1 
ATOM   1873 O O   . ILE   A 1 250 ? 24.98300  -20.19000 -30.80600 1.000 66.72543 ? 446 ILE   A O   1 
ATOM   1874 C CB  . ILE   A 1 250 ? 22.67900  -22.30300 -30.32300 1.000 55.25287 ? 446 ILE   A CB  1 
ATOM   1875 C CG1 . ILE   A 1 250 ? 22.46200  -23.71300 -29.84300 1.000 55.41090 ? 446 ILE   A CG1 1 
ATOM   1876 C CG2 . ILE   A 1 250 ? 23.14700  -22.33600 -31.74500 1.000 59.34018 ? 446 ILE   A CG2 1 
ATOM   1877 C CD1 . ILE   A 1 250 ? 21.42600  -24.44600 -30.63200 1.000 55.91767 ? 446 ILE   A CD1 1 
ATOM   1878 N N   . ILE   A 1 251 ? 23.30400  -19.25800 -29.73900 1.000 61.77126 ? 447 ILE   A N   1 
ATOM   1879 C CA  . ILE   A 1 251 ? 23.62700  -17.92600 -30.23000 1.000 62.90844 ? 447 ILE   A CA  1 
ATOM   1880 C C   . ILE   A 1 251 ? 24.85800  -17.39100 -29.51300 1.000 62.75169 ? 447 ILE   A C   1 
ATOM   1881 O O   . ILE   A 1 251 ? 25.76200  -16.81700 -30.13000 1.000 66.48285 ? 447 ILE   A O   1 
ATOM   1882 C CB  . ILE   A 1 251 ? 22.42100  -16.98900 -30.04700 1.000 61.06645 ? 447 ILE   A CB  1 
ATOM   1883 C CG1 . ILE   A 1 251 ? 21.25700  -17.43900 -30.93000 1.000 58.93604 ? 447 ILE   A CG1 1 
ATOM   1884 C CG2 . ILE   A 1 251 ? 22.81700  -15.54700 -30.33100 1.000 60.76384 ? 447 ILE   A CG2 1 
ATOM   1885 C CD1 . ILE   A 1 251 ? 21.29100  -16.87800 -32.30200 1.000 60.09996 ? 447 ILE   A CD1 1 
ATOM   1886 N N   . LYS   A 1 252 ? 24.89700  -17.55900 -28.19400 1.000 62.99848 ? 448 LYS   A N   1 
ATOM   1887 C CA  . LYS   A 1 252 ? 26.05300  -17.12900 -27.41700 1.000 63.73512 ? 448 LYS   A CA  1 
ATOM   1888 C C   . LYS   A 1 252 ? 27.32400  -17.76100 -27.96500 1.000 64.94394 ? 448 LYS   A C   1 
ATOM   1889 O O   . LYS   A 1 252 ? 28.34700  -17.09300 -28.14100 1.000 69.73314 ? 448 LYS   A O   1 
ATOM   1890 C CB  . LYS   A 1 252 ? 25.84700  -17.51800 -25.95300 1.000 62.81251 ? 448 LYS   A CB  1 
ATOM   1891 C CG  . LYS   A 1 252 ? 26.33200  -16.50900 -24.94400 1.000 67.10051 ? 448 LYS   A CG  1 
ATOM   1892 C CD  . LYS   A 1 252 ? 25.25800  -16.25500 -23.89400 1.000 62.17935 ? 448 LYS   A CD  1 
ATOM   1893 C CE  . LYS   A 1 252 ? 25.40300  -17.24300 -22.74600 1.000 70.30177 ? 448 LYS   A CE  1 
ATOM   1894 N NZ  . LYS   A 1 252 ? 24.43000  -17.01500 -21.63700 1.000 66.11554 ? 448 LYS   A NZ  1 
ATOM   1895 N N   . LYS   A 1 253 ? 27.25100  -19.04900 -28.28600 1.000 64.73285 ? 449 LYS   A N   1 
ATOM   1896 C CA  . LYS   A 1 253 ? 28.42400  -19.82500 -28.65900 1.000 66.76947 ? 449 LYS   A CA  1 
ATOM   1897 C C   . LYS   A 1 253 ? 28.85800  -19.55800 -30.09900 1.000 71.34615 ? 449 LYS   A C   1 
ATOM   1898 O O   . LYS   A 1 253 ? 30.04400  -19.33200 -30.36300 1.000 71.57459 ? 449 LYS   A O   1 
ATOM   1899 C CB  . LYS   A 1 253 ? 28.12400  -21.31200 -28.46000 1.000 67.65400 ? 449 LYS   A CB  1 
ATOM   1900 C CG  . LYS   A 1 253 ? 29.22800  -22.11400 -27.79700 1.000 75.50042 ? 449 LYS   A CG  1 
ATOM   1901 C CD  . LYS   A 1 253 ? 29.04500  -23.61300 -28.06000 1.000 75.06441 ? 449 LYS   A CD  1 
ATOM   1902 C CE  . LYS   A 1 253 ? 30.34300  -24.40800 -27.85200 1.000 76.69006 ? 449 LYS   A CE  1 
ATOM   1903 N NZ  . LYS   A 1 253 ? 31.09300  -24.00700 -26.62300 1.000 79.59616 ? 449 LYS   A NZ  1 
ATOM   1904 N N   . THR   A 1 254 ? 27.93000  -19.68500 -31.02200 1.000 70.86095 ? 450 THR   A N   1 
ATOM   1905 C CA  . THR   A 1 254 ? 28.23900  -19.62300 -32.42200 1.000 68.71680 ? 450 THR   A CA  1 
ATOM   1906 C C   . THR   A 1 254 ? 27.82400  -18.45900 -33.29000 1.000 69.97537 ? 450 THR   A C   1 
ATOM   1907 O O   . THR   A 1 254 ? 27.79600  -18.61400 -34.49200 1.000 72.94277 ? 450 THR   A O   1 
ATOM   1908 C CB  . THR   A 1 254 ? 27.63500  -20.84800 -33.09900 1.000 69.43932 ? 450 THR   A CB  1 
ATOM   1909 O OG1 . THR   A 1 254 ? 26.27700  -20.58600 -33.41100 1.000 67.02672 ? 450 THR   A OG1 1 
ATOM   1910 C CG2 . THR   A 1 254 ? 27.69500  -22.02600 -32.20700 1.000 64.53398 ? 450 THR   A CG2 1 
ATOM   1911 N N   . GLU   A 1 255 ? 27.48200  -17.31600 -32.73600 1.000 67.35288 ? 451 GLU   A N   1 
ATOM   1912 C CA  . GLU   A 1 255 ? 27.11400  -16.22900 -33.60800 1.000 69.86249 ? 451 GLU   A CA  1 
ATOM   1913 C C   . GLU   A 1 255 ? 27.94800  -15.02900 -33.28800 1.000 75.19294 ? 451 GLU   A C   1 
ATOM   1914 O O   . GLU   A 1 255 ? 27.98200  -14.56900 -32.16900 1.000 73.98114 ? 451 GLU   A O   1 
ATOM   1915 C CB  . GLU   A 1 255 ? 25.62400  -15.92500 -33.56600 1.000 69.14380 ? 451 GLU   A CB  1 
ATOM   1916 C CG  . GLU   A 1 255 ? 24.75900  -17.01600 -34.17600 1.000 65.10942 ? 451 GLU   A CG  1 
ATOM   1917 C CD  . GLU   A 1 255 ? 24.83500  -17.07100 -35.68300 1.000 66.99462 ? 451 GLU   A CD  1 
ATOM   1918 O OE1 . GLU   A 1 255 ? 24.59900  -18.14300 -36.25100 1.000 64.42285 ? 451 GLU   A OE1 1 
ATOM   1919 O OE2 . GLU   A 1 255 ? 25.12200  -16.04800 -36.30400 1.000 66.36322 ? 451 GLU   A OE2 1 
ATOM   1920 N N   . SER   A 1 256 ? 28.62600  -14.51900 -34.30100 1.000 75.24005 ? 452 SER   A N   1 
ATOM   1921 C CA  . SER   A 1 256 ? 29.50500  -13.38900 -34.11100 1.000 75.25494 ? 452 SER   A CA  1 
ATOM   1922 C C   . SER   A 1 256 ? 28.81500  -12.05700 -33.93700 1.000 73.49302 ? 452 SER   A C   1 
ATOM   1923 O O   . SER   A 1 256 ? 29.11700  -11.32400 -33.02300 1.000 76.78847 ? 452 SER   A O   1 
ATOM   1924 C CB  . SER   A 1 256 ? 30.55200  -13.30500 -35.22800 1.000 73.82256 ? 452 SER   A CB  1 
ATOM   1925 O OG  . SER   A 1 256 ? 30.24200  -14.11900 -36.34200 1.000 74.50729 ? 452 SER   A OG  1 
ATOM   1926 N N   . ASP   A 1 257 ? 27.87900  -11.74000 -34.79400 1.000 71.53507 ? 453 ASP   A N   1 
ATOM   1927 C CA  . ASP   A 1 257 ? 27.26400  -10.43500 -34.68700 1.000 76.38205 ? 453 ASP   A CA  1 
ATOM   1928 C C   . ASP   A 1 257 ? 25.96300  -10.36300 -33.90200 1.000 76.28991 ? 453 ASP   A C   1 
ATOM   1929 O O   . ASP   A 1 257 ? 25.20700  -9.42400  -34.07600 1.000 78.17148 ? 453 ASP   A O   1 
ATOM   1930 C CB  . ASP   A 1 257 ? 27.06900  -9.82300  -36.07300 1.000 75.10882 ? 453 ASP   A CB  1 
ATOM   1931 C CG  . ASP   A 1 257 ? 27.67600  -8.44000  -36.19900 1.000 82.71293 ? 453 ASP   A CG  1 
ATOM   1932 O OD1 . ASP   A 1 257 ? 27.24100  -7.69000  -37.09300 1.000 81.23858 ? 453 ASP   A OD1 1 
ATOM   1933 O OD2 . ASP   A 1 257 ? 28.59800  -8.10700  -35.43100 1.000 80.44304 ? 453 ASP   A OD2 1 
ATOM   1934 N N   . ALA   A 1 258 ? 25.70900  -11.33400 -33.04200 1.000 71.58676 ? 454 ALA   A N   1 
ATOM   1935 C CA  . ALA   A 1 258 ? 24.49800  -11.34400 -32.22100 1.000 65.39722 ? 454 ALA   A CA  1 
ATOM   1936 C C   . ALA   A 1 258 ? 24.88600  -11.20100 -30.75000 1.000 62.13360 ? 454 ALA   A C   1 
ATOM   1937 O O   . ALA   A 1 258 ? 24.81400  -12.14600 -29.96300 1.000 63.58701 ? 454 ALA   A O   1 
ATOM   1938 C CB  . ALA   A 1 258 ? 23.69200  -12.62100 -32.47100 1.000 63.02834 ? 454 ALA   A CB  1 
ATOM   1939 N N   . ALA   A 1 259 ? 25.31600  -9.99900  -30.38200 1.000 62.10896 ? 455 ALA   A N   1 
ATOM   1940 C CA  . ALA   A 1 259 ? 25.73300  -9.75400  -29.00900 1.000 61.36297 ? 455 ALA   A CA  1 
ATOM   1941 C C   . ALA   A 1 259 ? 24.51900  -9.69500  -28.09000 1.000 62.15506 ? 455 ALA   A C   1 
ATOM   1942 O O   . ALA   A 1 259 ? 23.58200  -8.92700  -28.32600 1.000 59.00049 ? 455 ALA   A O   1 
ATOM   1943 C CB  . ALA   A 1 259 ? 26.52500  -8.45200  -28.91800 1.000 61.50882 ? 455 ALA   A CB  1 
ATOM   1944 N N   . LEU   A 1 260 ? 24.54000  -10.50100 -27.03600 1.000 59.49313 ? 456 LEU   A N   1 
ATOM   1945 C CA  . LEU   A 1 260 ? 23.44900  -10.48200 -26.07800 1.000 58.67385 ? 456 LEU   A CA  1 
ATOM   1946 C C   . LEU   A 1 260 ? 23.49000  -9.18600  -25.27800 1.000 58.64132 ? 456 LEU   A C   1 
ATOM   1947 O O   . LEU   A 1 260 ? 24.54400  -8.79100  -24.77300 1.000 62.14665 ? 456 LEU   A O   1 
ATOM   1948 C CB  . LEU   A 1 260 ? 23.55000  -11.68700 -25.14800 1.000 62.68691 ? 456 LEU   A CB  1 
ATOM   1949 C CG  . LEU   A 1 260 ? 22.61300  -12.86900 -25.39600 1.000 63.87122 ? 456 LEU   A CG  1 
ATOM   1950 C CD1 . LEU   A 1 260 ? 23.11500  -13.70100 -26.57600 1.000 62.91286 ? 456 LEU   A CD1 1 
ATOM   1951 C CD2 . LEU   A 1 260 ? 22.49600  -13.73500 -24.14300 1.000 59.92626 ? 456 LEU   A CD2 1 
ATOM   1952 N N   . HIS   A 1 261 ? 22.35000  -8.51300  -25.18500 1.000 54.39686 ? 457 HIS   A N   1 
ATOM   1953 C CA  . HIS   A 1 261 ? 22.23200  -7.35100  -24.31300 1.000 54.77700 ? 457 HIS   A CA  1 
ATOM   1954 C C   . HIS   A 1 261 ? 22.63300  -7.73000  -22.88600 1.000 53.22729 ? 457 HIS   A C   1 
ATOM   1955 O O   . HIS   A 1 261 ? 22.29900  -8.82900  -22.41500 1.000 54.16820 ? 457 HIS   A O   1 
ATOM   1956 C CB  . HIS   A 1 261 ? 20.79200  -6.82800  -24.35500 1.000 53.26645 ? 457 HIS   A CB  1 
ATOM   1957 C CG  . HIS   A 1 261 ? 20.57700  -5.51600  -23.66300 1.000 50.77786 ? 457 HIS   A CG  1 
ATOM   1958 N ND1 . HIS   A 1 261 ? 20.62000  -5.38100  -22.29000 1.000 51.05051 ? 457 HIS   A ND1 1 
ATOM   1959 C CD2 . HIS   A 1 261 ? 20.25500  -4.29100  -24.15200 1.000 45.82297 ? 457 HIS   A CD2 1 
ATOM   1960 C CE1 . HIS   A 1 261 ? 20.36300  -4.12400  -21.96500 1.000 47.07830 ? 457 HIS   A CE1 1 
ATOM   1961 N NE2 . HIS   A 1 261 ? 20.13000  -3.44400  -23.07600 1.000 46.46919 ? 457 HIS   A NE2 1 
ATOM   1962 N N   . PRO   A 1 262 ? 23.35800  -6.86300  -22.17300 1.000 52.69441 ? 458 PRO   A N   1 
ATOM   1963 C CA  . PRO   A 1 262 ? 23.79500  -7.22500  -20.80900 1.000 53.38062 ? 458 PRO   A CA  1 
ATOM   1964 C C   . PRO   A 1 262 ? 22.66300  -7.57700  -19.85200 1.000 55.18967 ? 458 PRO   A C   1 
ATOM   1965 O O   . PRO   A 1 262 ? 22.80200  -8.54900  -19.09500 1.000 51.68689 ? 458 PRO   A O   1 
ATOM   1966 C CB  . PRO   A 1 262 ? 24.57100  -5.99200  -20.33000 1.000 51.31716 ? 458 PRO   A CB  1 
ATOM   1967 C CG  . PRO   A 1 262 ? 24.59700  -5.03700  -21.44600 1.000 55.55906 ? 458 PRO   A CG  1 
ATOM   1968 C CD  . PRO   A 1 262 ? 23.77600  -5.51400  -22.57900 1.000 52.37465 ? 458 PRO   A CD  1 
ATOM   1969 N N   . LEU   A 1 263 ? 21.55800  -6.81900  -19.84000 1.000 52.90265 ? 459 LEU   A N   1 
ATOM   1970 C CA  . LEU   A 1 263 ? 20.43900  -7.19700  -18.97700 1.000 51.48193 ? 459 LEU   A CA  1 
ATOM   1971 C C   . LEU   A 1 263 ? 20.00500  -8.63400  -19.24000 1.000 51.08023 ? 459 LEU   A C   1 
ATOM   1972 O O   . LEU   A 1 263 ? 19.73200  -9.39400  -18.30000 1.000 48.45324 ? 459 LEU   A O   1 
ATOM   1973 C CB  . LEU   A 1 263 ? 19.25700  -6.24200  -19.16600 1.000 47.81026 ? 459 LEU   A CB  1 
ATOM   1974 C CG  . LEU   A 1 263 ? 17.99200  -6.67200  -18.40900 1.000 49.01166 ? 459 LEU   A CG  1 
ATOM   1975 C CD1 . LEU   A 1 263 ? 18.25700  -6.68700  -16.90200 1.000 49.66979 ? 459 LEU   A CD1 1 
ATOM   1976 C CD2 . LEU   A 1 263 ? 16.82400  -5.74800  -18.71800 1.000 42.37340 ? 459 LEU   A CD2 1 
ATOM   1977 N N   . LEU   A 1 264 ? 19.97100  -9.03700  -20.51200 1.000 48.65832 ? 460 LEU   A N   1 
ATOM   1978 C CA  . LEU   A 1 264 ? 19.55600  -10.39500 -20.84200 1.000 48.34993 ? 460 LEU   A CA  1 
ATOM   1979 C C   . LEU   A 1 264 ? 20.63200  -11.41300 -20.49000 1.000 54.58843 ? 460 LEU   A C   1 
ATOM   1980 O O   . LEU   A 1 264 ? 20.30300  -12.54100 -20.09600 1.000 50.40304 ? 460 LEU   A O   1 
ATOM   1981 C CB  . LEU   A 1 264 ? 19.19300  -10.49900 -22.32400 1.000 49.51205 ? 460 LEU   A CB  1 
ATOM   1982 C CG  . LEU   A 1 264 ? 18.09800  -9.54800  -22.81900 1.000 47.90927 ? 460 LEU   A CG  1 
ATOM   1983 C CD1 . LEU   A 1 264 ? 17.52400  -10.02800 -24.15400 1.000 48.27144 ? 460 LEU   A CD1 1 
ATOM   1984 C CD2 . LEU   A 1 264 ? 17.00300  -9.36000  -21.78100 1.000 44.34321 ? 460 LEU   A CD2 1 
ATOM   1985 N N   . GLN   A 1 265 ? 21.91600  -11.05100 -20.62200 1.000 55.70259 ? 461 GLN   A N   1 
ATOM   1986 C CA  . GLN   A 1 265 ? 22.96000  -11.96600 -20.15200 1.000 58.86125 ? 461 GLN   A CA  1 
ATOM   1987 C C   . GLN   A 1 265 ? 22.76600  -12.28100 -18.67300 1.000 52.43419 ? 461 GLN   A C   1 
ATOM   1988 O O   . GLN   A 1 265 ? 22.91300  -13.43200 -18.24900 1.000 57.10601 ? 461 GLN   A O   1 
ATOM   1989 C CB  . GLN   A 1 265 ? 24.36600  -11.39300 -20.39700 1.000 56.71997 ? 461 GLN   A CB  1 
ATOM   1990 C CG  . GLN   A 1 265 ? 25.42400  -12.49300 -20.70900 1.000 68.01118 ? 461 GLN   A CG  1 
ATOM   1991 C CD  . GLN   A 1 265 ? 26.46600  -12.72800 -19.58300 1.000 71.47552 ? 461 GLN   A CD  1 
ATOM   1992 O OE1 . GLN   A 1 265 ? 26.86000  -11.79900 -18.86900 1.000 69.12110 ? 461 GLN   A OE1 1 
ATOM   1993 N NE2 . GLN   A 1 265 ? 26.91100  -13.98000 -19.43300 1.000 64.03716 ? 461 GLN   A NE2 1 
ATOM   1994 N N   . GLU   A 1 266 ? 22.40800  -11.26900 -17.88300 1.000 51.61534 ? 462 GLU   A N   1 
ATOM   1995 C CA  . GLU   A 1 266 ? 22.17900  -11.46500 -16.45800 1.000 53.71412 ? 462 GLU   A CA  1 
ATOM   1996 C C   . GLU   A 1 266 ? 21.03400  -12.43900 -16.21000 1.000 53.82271 ? 462 GLU   A C   1 
ATOM   1997 O O   . GLU   A 1 266 ? 21.15300  -13.36600 -15.39600 1.000 50.21162 ? 462 GLU   A O   1 
ATOM   1998 C CB  . GLU   A 1 266 ? 21.89300  -10.11500 -15.81000 1.000 55.32078 ? 462 GLU   A CB  1 
ATOM   1999 C CG  . GLU   A 1 266 ? 21.56000  -10.14700 -14.33800 1.000 51.53990 ? 462 GLU   A CG  1 
ATOM   2000 C CD  . GLU   A 1 266 ? 21.68700  -8.76800  -13.72200 1.000 59.12562 ? 462 GLU   A CD  1 
ATOM   2001 O OE1 . GLU   A 1 266 ? 22.58500  -8.02500  -14.16800 1.000 63.19360 ? 462 GLU   A OE1 1 
ATOM   2002 O OE2 . GLU   A 1 266 ? 20.90000  -8.41600  -12.81000 1.000 57.24816 ? 462 GLU   A OE2 1 
ATOM   2003 N N   . ILE   A 1 267 ? 19.91100  -12.24000 -16.90800 1.000 49.80168 ? 463 ILE   A N   1 
ATOM   2004 C CA  . ILE   A 1 267 ? 18.75700  -13.11600 -16.74100 1.000 49.91362 ? 463 ILE   A CA  1 
ATOM   2005 C C   . ILE   A 1 267 ? 19.12700  -14.55000 -17.08300 1.000 48.96715 ? 463 ILE   A C   1 
ATOM   2006 O O   . ILE   A 1 267 ? 18.75200  -15.49000 -16.37200 1.000 51.43778 ? 463 ILE   A O   1 
ATOM   2007 C CB  . ILE   A 1 267 ? 17.58200  -12.61600 -17.60200 1.000 50.85939 ? 463 ILE   A CB  1 
ATOM   2008 C CG1 . ILE   A 1 267 ? 17.04700  -11.31200 -17.04200 1.000 39.40438 ? 463 ILE   A CG1 1 
ATOM   2009 C CG2 . ILE   A 1 267 ? 16.45800  -13.67300 -17.68600 1.000 42.40986 ? 463 ILE   A CG2 1 
ATOM   2010 C CD1 . ILE   A 1 267 ? 16.02700  -10.64100 -17.94400 1.000 44.22119 ? 463 ILE   A CD1 1 
ATOM   2011 N N   . TYR   A 1 268 ? 19.89200  -14.74000 -18.15400 1.000 48.35753 ? 464 TYR   A N   1 
ATOM   2012 C CA  . TYR   A 1 268 ? 20.18200  -16.08400 -18.63200 1.000 54.94999 ? 464 TYR   A CA  1 
ATOM   2013 C C   . TYR   A 1 268 ? 21.35800  -16.76300 -17.91700 1.000 56.16411 ? 464 TYR   A C   1 
ATOM   2014 O O   . TYR   A 1 268 ? 21.57700  -17.95800 -18.13400 1.000 58.20453 ? 464 TYR   A O   1 
ATOM   2015 C CB  . TYR   A 1 268 ? 20.43400  -16.03100 -20.13700 1.000 51.17724 ? 464 TYR   A CB  1 
ATOM   2016 C CG  . TYR   A 1 268 ? 19.17000  -15.95900 -20.96700 1.000 56.17752 ? 464 TYR   A CG  1 
ATOM   2017 C CD1 . TYR   A 1 268 ? 18.29000  -17.03400 -21.01400 1.000 52.40424 ? 464 TYR   A CD1 1 
ATOM   2018 C CD2 . TYR   A 1 268 ? 18.85800  -14.81500 -21.71200 1.000 51.23209 ? 464 TYR   A CD2 1 
ATOM   2019 C CE1 . TYR   A 1 268 ? 17.12800  -16.98400 -21.78000 1.000 51.65432 ? 464 TYR   A CE1 1 
ATOM   2020 C CE2 . TYR   A 1 268 ? 17.69900  -14.75400 -22.48900 1.000 49.51226 ? 464 TYR   A CE2 1 
ATOM   2021 C CZ  . TYR   A 1 268 ? 16.83900  -15.84500 -22.51400 1.000 50.64067 ? 464 TYR   A CZ  1 
ATOM   2022 O OH  . TYR   A 1 268 ? 15.69300  -15.81400 -23.27000 1.000 49.01779 ? 464 TYR   A OH  1 
ATOM   2023 N N   . ARG   A 1 269 ? 22.10800  -16.05400 -17.07600 1.000 56.13715 ? 465 ARG   A N   1 
ATOM   2024 C CA  . ARG   A 1 269 ? 23.22000  -16.67100 -16.35300 1.000 62.02658 ? 465 ARG   A CA  1 
ATOM   2025 C C   . ARG   A 1 269 ? 22.73800  -17.84000 -15.50100 1.000 66.58809 ? 465 ARG   A C   1 
ATOM   2026 O O   . ARG   A 1 269 ? 21.95600  -17.64800 -14.56200 1.000 62.26873 ? 465 ARG   A O   1 
ATOM   2027 C CB  . ARG   A 1 269 ? 23.91200  -15.63700 -15.47200 1.000 62.33945 ? 465 ARG   A CB  1 
ATOM   2028 C CG  . ARG   A 1 269 ? 25.09600  -14.96100 -16.12600 1.000 66.38879 ? 465 ARG   A CG  1 
ATOM   2029 C CD  . ARG   A 1 269 ? 26.08300  -14.45200 -15.08200 1.000 68.20458 ? 465 ARG   A CD  1 
ATOM   2030 N NE  . ARG   A 1 269 ? 25.74500  -13.11200 -14.61500 1.000 63.94765 ? 465 ARG   A NE  1 
ATOM   2031 C CZ  . ARG   A 1 269 ? 25.86700  -12.01100 -15.34500 1.000 64.76610 ? 465 ARG   A CZ  1 
ATOM   2032 N NH1 . ARG   A 1 269 ? 26.31800  -12.05400 -16.58900 1.000 63.51967 ? 465 ARG   A NH1 1 
ATOM   2033 N NH2 . ARG   A 1 269 ? 25.53600  -10.83700 -14.81200 1.000 60.03223 ? 465 ARG   A NH2 1 
ATOM   2034 N N   . ASP   A 1 270 ? 23.25200  -19.04100 -15.81300 1.000 66.79435 ? 466 ASP   A N   1 
ATOM   2035 C CA  . ASP   A 1 270 ? 22.87000  -20.32900 -15.22700 1.000 72.04929 ? 466 ASP   A CA  1 
ATOM   2036 C C   . ASP   A 1 270 ? 21.39600  -20.40300 -14.83900 1.000 75.78000 ? 466 ASP   A C   1 
ATOM   2037 O O   . ASP   A 1 270 ? 21.06100  -20.49300 -13.65300 1.000 76.47026 ? 466 ASP   A O   1 
ATOM   2038 C CB  . ASP   A 1 270 ? 23.74600  -20.68000 -14.01100 1.000 74.39362 ? 466 ASP   A CB  1 
ATOM   2039 C CG  . ASP   A 1 270 ? 24.05500  -19.48800 -13.12700 1.000 76.49506 ? 466 ASP   A CG  1 
ATOM   2040 O OD1 . ASP   A 1 270 ? 23.12500  -18.94300 -12.49500 1.000 77.85056 ? 466 ASP   A OD1 1 
ATOM   2041 O OD2 . ASP   A 1 270 ? 25.24000  -19.10000 -13.05600 1.000 80.99884 ? 466 ASP   A OD2 1 
ATOM   2042 N N   . MET   A 1 271 ? 20.51600  -20.38200 -15.83500 1.000 75.76204 ? 467 MET   A N   1 
ATOM   2043 C CA  . MET   A 1 271 ? 19.08900  -20.54900 -15.59900 1.000 73.42657 ? 467 MET   A CA  1 
ATOM   2044 C C   . MET   A 1 271 ? 18.63100  -21.93600 -16.05100 1.000 76.60995 ? 467 MET   A C   1 
ATOM   2045 O O   . MET   A 1 271 ? 18.55400  -22.87300 -15.25200 1.000 78.94572 ? 467 MET   A O   1 
ATOM   2046 C CB  . MET   A 1 271 ? 18.29600  -19.46300 -16.32700 1.000 73.51383 ? 467 MET   A CB  1 
ATOM   2047 C CG  . MET   A 1 271 ? 16.80900  -19.78100 -16.48100 1.000 77.40805 ? 467 MET   A CG  1 
ATOM   2048 S SD  . MET   A 1 271 ? 15.86100  -18.39500 -17.13500 1.000 71.48942 ? 467 MET   A SD  1 
ATOM   2049 C CE  . MET   A 1 271 ? 15.97300  -18.73900 -18.87900 1.000 59.24584 ? 467 MET   A CE  1 
ATOM   2050 N N   . PRO   B 2 7   ? 26.14600  -3.15700  -10.15400 1.000 73.74512 ? 141 PRO   B N   1 
ATOM   2051 C CA  . PRO   B 2 7   ? 26.32200  -4.59700  -10.37500 1.000 71.14166 ? 141 PRO   B CA  1 
ATOM   2052 C C   . PRO   B 2 7   ? 25.15900  -5.25100  -11.13800 1.000 70.54840 ? 141 PRO   B C   1 
ATOM   2053 O O   . PRO   B 2 7   ? 25.15700  -5.21900  -12.36800 1.000 67.26184 ? 141 PRO   B O   1 
ATOM   2054 C CB  . PRO   B 2 7   ? 26.44700  -5.15600  -8.94500  1.000 71.89618 ? 141 PRO   B CB  1 
ATOM   2055 C CG  . PRO   B 2 7   ? 25.93400  -4.06900  -8.03900  1.000 72.61988 ? 141 PRO   B CG  1 
ATOM   2056 C CD  . PRO   B 2 7   ? 26.31600  -2.79900  -8.73400  1.000 74.04284 ? 141 PRO   B CD  1 
ATOM   2057 N N   . SER   B 2 8   ? 24.19900  -5.84300  -10.42800 1.000 67.52926 ? 142 SER   B N   1 
ATOM   2058 C CA  . SER   B 2 8   ? 23.10500  -6.54700  -11.09000 1.000 64.15314 ? 142 SER   B CA  1 
ATOM   2059 C C   . SER   B 2 8   ? 22.16700  -5.55400  -11.76800 1.000 59.21097 ? 142 SER   B C   1 
ATOM   2060 O O   . SER   B 2 8   ? 21.67400  -4.62000  -11.12900 1.000 54.44457 ? 142 SER   B O   1 
ATOM   2061 C CB  . SER   B 2 8   ? 22.33700  -7.40500  -10.08400 1.000 63.12687 ? 142 SER   B CB  1 
ATOM   2062 O OG  . SER   B 2 8   ? 20.95600  -7.46400  -10.41700 1.000 58.95415 ? 142 SER   B OG  1 
ATOM   2063 N N   . LEU   B 2 9   ? 21.90500  -5.76200  -13.05900 1.000 58.66020 ? 143 LEU   B N   1 
ATOM   2064 C CA  . LEU   B 2 9   ? 20.98700  -4.86700  -13.75600 1.000 58.13666 ? 143 LEU   B CA  1 
ATOM   2065 C C   . LEU   B 2 9   ? 19.54100  -5.05300  -13.28800 1.000 55.44564 ? 143 LEU   B C   1 
ATOM   2066 O O   . LEU   B 2 9   ? 18.77400  -4.07500  -13.23900 1.000 47.83550 ? 143 LEU   B O   1 
ATOM   2067 C CB  . LEU   B 2 9   ? 21.12300  -5.07100  -15.25800 1.000 55.87651 ? 143 LEU   B CB  1 
ATOM   2068 C CG  . LEU   B 2 9   ? 22.46900  -4.56900  -15.78000 1.000 56.71627 ? 143 LEU   B CG  1 
ATOM   2069 C CD1 . LEU   B 2 9   ? 22.85600  -5.26700  -17.08000 1.000 54.41094 ? 143 LEU   B CD1 1 
ATOM   2070 C CD2 . LEU   B 2 9   ? 22.41400  -3.06200  -15.95600 1.000 56.81816 ? 143 LEU   B CD2 1 
ATOM   2071 N N   . LEU   B 2 10  ? 19.15700  -6.27800  -12.90600 1.000 50.77893 ? 144 LEU   B N   1 
ATOM   2072 C CA  . LEU   B 2 10  ? 17.80400  -6.48100  -12.38900 1.000 50.27281 ? 144 LEU   B CA  1 
ATOM   2073 C C   . LEU   B 2 10  ? 17.58300  -5.69900  -11.09800 1.000 50.63657 ? 144 LEU   B C   1 
ATOM   2074 O O   . LEU   B 2 10  ? 16.50100  -5.13800  -10.88700 1.000 49.10679 ? 144 LEU   B O   1 
ATOM   2075 C CB  . LEU   B 2 10  ? 17.51800  -7.97000  -12.16800 1.000 47.00110 ? 144 LEU   B CB  1 
ATOM   2076 C CG  . LEU   B 2 10  ? 17.32900  -8.84700  -13.41000 1.000 52.39905 ? 144 LEU   B CG  1 
ATOM   2077 C CD1 . LEU   B 2 10  ? 17.44700  -10.34500 -13.07700 1.000 50.27431 ? 144 LEU   B CD1 1 
ATOM   2078 C CD2 . LEU   B 2 10  ? 15.99700  -8.53100  -14.08900 1.000 48.45535 ? 144 LEU   B CD2 1 
ATOM   2079 N N   . LYS   B 2 11  ? 18.59600  -5.64200  -10.22200 1.000 50.09688 ? 145 LYS   B N   1 
ATOM   2080 C CA  . LYS   B 2 11  ? 18.47900  -4.82900  -9.01300  1.000 48.74151 ? 145 LYS   B CA  1 
ATOM   2081 C C   . LYS   B 2 11  ? 18.21200  -3.36100  -9.34200  1.000 51.54299 ? 145 LYS   B C   1 
ATOM   2082 O O   . LYS   B 2 11  ? 17.34800  -2.73000  -8.71700  1.000 52.96291 ? 145 LYS   B O   1 
ATOM   2083 C CB  . LYS   B 2 11  ? 19.74200  -4.95700  -8.15900  1.000 54.44174 ? 145 LYS   B CB  1 
ATOM   2084 C CG  . LYS   B 2 11  ? 19.97000  -6.33100  -7.55800  1.000 55.25949 ? 145 LYS   B CG  1 
ATOM   2085 C CD  . LYS   B 2 11  ? 20.32100  -6.24600  -6.08000  1.000 56.94370 ? 145 LYS   B CD  1 
ATOM   2086 C CE  . LYS   B 2 11  ? 21.02500  -7.51400  -5.62900  1.000 59.42849 ? 145 LYS   B CE  1 
ATOM   2087 N NZ  . LYS   B 2 11  ? 21.49500  -7.44600  -4.21600  1.000 58.85718 ? 145 LYS   B NZ  1 
ATOM   2088 N N   . LYS   B 2 12  ? 18.94600  -2.79400  -10.31000 1.000 50.56019 ? 146 LYS   B N   1 
ATOM   2089 C CA  . LYS   B 2 12  ? 18.74600  -1.38200  -10.65800 1.000 53.15660 ? 146 LYS   B CA  1 
ATOM   2090 C C   . LYS   B 2 12  ? 17.32800  -1.13600  -11.14100 1.000 51.25210 ? 146 LYS   B C   1 
ATOM   2091 O O   . LYS   B 2 12  ? 16.73500  -0.09300  -10.84200 1.000 54.62740 ? 146 LYS   B O   1 
ATOM   2092 C CB  . LYS   B 2 12  ? 19.72700  -0.90600  -11.73800 1.000 51.79570 ? 146 LYS   B CB  1 
ATOM   2093 C CG  . LYS   B 2 12  ? 21.10700  -1.52300  -11.75900 1.000 59.83195 ? 146 LYS   B CG  1 
ATOM   2094 C CD  . LYS   B 2 12  ? 21.66700  -1.74400  -10.38000 1.000 61.19960 ? 146 LYS   B CD  1 
ATOM   2095 C CE  . LYS   B 2 12  ? 23.13800  -2.04700  -10.41700 1.000 67.42751 ? 146 LYS   B CE  1 
ATOM   2096 N NZ  . LYS   B 2 12  ? 23.32700  -3.21200  -9.49600  1.000 65.49432 ? 146 LYS   B NZ  1 
ATOM   2097 N N   . LEU   B 2 13  ? 16.77500  -2.07800  -11.91100 1.000 50.45936 ? 147 LEU   B N   1 
ATOM   2098 C CA  . LEU   B 2 13  ? 15.38500  -1.95400  -12.33700 1.000 52.42315 ? 147 LEU   B CA  1 
ATOM   2099 C C   . LEU   B 2 13  ? 14.46900  -1.91100  -11.12800 1.000 51.00325 ? 147 LEU   B C   1 
ATOM   2100 O O   . LEU   B 2 13  ? 13.57900  -1.05800  -11.03600 1.000 53.29378 ? 147 LEU   B O   1 
ATOM   2101 C CB  . LEU   B 2 13  ? 15.01800  -3.12900  -13.24200 1.000 49.44168 ? 147 LEU   B CB  1 
ATOM   2102 C CG  . LEU   B 2 13  ? 15.36900  -3.02800  -14.72300 1.000 45.53763 ? 147 LEU   B CG  1 
ATOM   2103 C CD1 . LEU   B 2 13  ? 14.58700  -4.06200  -15.49300 1.000 47.18207 ? 147 LEU   B CD1 1 
ATOM   2104 C CD2 . LEU   B 2 13  ? 15.09500  -1.63100  -15.26100 1.000 44.89061 ? 147 LEU   B CD2 1 
ATOM   2105 N N   . LEU   B 2 14  ? 14.69900  -2.81100  -10.17400 1.000 50.36967 ? 148 LEU   B N   1 
ATOM   2106 C CA  . LEU   B 2 14  ? 13.84100  -2.88700  -9.00000  1.000 50.25117 ? 148 LEU   B CA  1 
ATOM   2107 C C   . LEU   B 2 14  ? 14.02100  -1.67500  -8.08800  1.000 54.41259 ? 148 LEU   B C   1 
ATOM   2108 O O   . LEU   B 2 14  ? 13.06500  -1.25500  -7.42500  1.000 57.26281 ? 148 LEU   B O   1 
ATOM   2109 C CB  . LEU   B 2 14  ? 14.12200  -4.18700  -8.24700  1.000 48.80101 ? 148 LEU   B CB  1 
ATOM   2110 C CG  . LEU   B 2 14  ? 13.42300  -5.40900  -8.84100  1.000 47.21287 ? 148 LEU   B CG  1 
ATOM   2111 C CD1 . LEU   B 2 14  ? 14.14500  -6.68200  -8.45600  1.000 46.50495 ? 148 LEU   B CD1 1 
ATOM   2112 C CD2 . LEU   B 2 14  ? 11.97800  -5.44700  -8.38900  1.000 44.04909 ? 148 LEU   B CD2 1 
ATOM   2113 N N   . LEU   B 2 15  ? 15.21500  -1.08300  -8.05500  1.000 53.27325 ? 149 LEU   B N   1 
ATOM   2114 C CA  . LEU   B 2 15  ? 15.47300  0.03200   -7.14800  1.000 61.66065 ? 149 LEU   B CA  1 
ATOM   2115 C C   . LEU   B 2 15  ? 15.14200  1.39500   -7.73600  1.000 64.03042 ? 149 LEU   B C   1 
ATOM   2116 O O   . LEU   B 2 15  ? 15.25600  2.39500   -7.02300  1.000 69.21425 ? 149 LEU   B O   1 
ATOM   2117 C CB  . LEU   B 2 15  ? 16.93700  0.02900   -6.71300  1.000 60.99479 ? 149 LEU   B CB  1 
ATOM   2118 C CG  . LEU   B 2 15  ? 17.21700  -1.05900  -5.69100  1.000 58.05399 ? 149 LEU   B CG  1 
ATOM   2119 C CD1 . LEU   B 2 15  ? 18.69500  -1.07700  -5.32600  1.000 58.80196 ? 149 LEU   B CD1 1 
ATOM   2120 C CD2 . LEU   B 2 15  ? 16.33400  -0.81900  -4.49700  1.000 59.13884 ? 149 LEU   B CD2 1 
ATOM   2121 N N   . ALA   B 2 16  ? 14.76000  1.46800   -9.00900  1.000 61.54367 ? 150 ALA   B N   1 
ATOM   2122 C CA  . ALA   B 2 16  ? 14.48000  2.75200   -9.62800  1.000 70.95785 ? 150 ALA   B CA  1 
ATOM   2123 C C   . ALA   B 2 16  ? 13.18800  3.35800   -9.07300  1.000 76.31381 ? 150 ALA   B C   1 
ATOM   2124 O O   . ALA   B 2 16  ? 12.26800  2.63000   -8.68000  1.000 74.18461 ? 150 ALA   B O   1 
ATOM   2125 C CB  . ALA   B 2 16  ? 14.37200  2.59700   -11.14300 1.000 65.80785 ? 150 ALA   B CB  1 
ATOM   2126 N N   . PRO   B 2 17  ? 13.10100  4.70100   -9.01700  1.000 78.82210 ? 151 PRO   B N   1 
ATOM   2127 C CA  . PRO   B 2 17  ? 11.89100  5.46500   -8.67400  1.000 81.03733 ? 151 PRO   B CA  1 
ATOM   2128 C C   . PRO   B 2 17  ? 10.62600  4.95300   -9.36200  1.000 78.85619 ? 151 PRO   B C   1 
ATOM   2129 O O   . PRO   B 2 17  ? 9.89000   4.17200   -8.75600  1.000 75.80591 ? 151 PRO   B O   1 
ATOM   2130 C CB  . PRO   B 2 17  ? 12.22000  6.88000   -9.16000  1.000 79.43017 ? 151 PRO   B CB  1 
ATOM   2131 C CG  . PRO   B 2 17  ? 13.71500  6.97000   -9.10600  1.000 82.58490 ? 151 PRO   B CG  1 
ATOM   2132 C CD  . PRO   B 2 17  ? 14.28800  5.57100   -9.12600  1.000 79.27067 ? 151 PRO   B CD  1 
HETATM 2133 C C01 . A1L0A C 3 .   ? 11.96900  -13.03500 -28.53800 1.000 41.74994 ? 500 A1L0A A C01 1 
HETATM 2134 C C02 . A1L0A C 3 .   ? 12.70000  -13.09100 -27.26000 1.000 41.02181 ? 500 A1L0A A C02 1 
HETATM 2135 C C03 . A1L0A C 3 .   ? 14.13200  -13.44400 -27.25600 1.000 38.96293 ? 500 A1L0A A C03 1 
HETATM 2136 C C04 . A1L0A C 3 .   ? 14.85900  -13.75500 -28.55600 1.000 45.17704 ? 500 A1L0A A C04 1 
HETATM 2137 C C05 . A1L0A C 3 .   ? 14.13200  -13.69900 -29.74000 1.000 45.92703 ? 500 A1L0A A C05 1 
HETATM 2138 C C06 . A1L0A C 3 .   ? 16.16100  -14.11500 -28.87400 1.000 42.94867 ? 500 A1L0A A C06 1 
HETATM 2139 C C08 . A1L0A C 3 .   ? 14.88800  -13.45900 -25.95400 1.000 45.46180 ? 500 A1L0A A C08 1 
HETATM 2140 C C09 . A1L0A C 3 .   ? 17.39500  -14.30900 -28.00300 1.000 46.63390 ? 500 A1L0A A C09 1 
HETATM 2141 C C10 . A1L0A C 3 .   ? 18.07500  -12.95100 -27.84000 1.000 47.36535 ? 500 A1L0A A C10 1 
HETATM 2142 C C11 . A1L0A C 3 .   ? 18.32700  -15.27900 -28.74400 1.000 46.57652 ? 500 A1L0A A C11 1 
HETATM 2143 C C12 . A1L0A C 3 .   ? 19.10600  -13.00900 -26.70600 1.000 54.82058 ? 500 A1L0A A C12 1 
HETATM 2144 C C13 . A1L0A C 3 .   ? 17.70000  -16.67100 -28.84900 1.000 44.89879 ? 500 A1L0A A C13 1 
HETATM 2145 C C14 . A1L0A C 3 .   ? 15.81600  -13.71800 -33.05800 1.000 46.65863 ? 500 A1L0A A C14 1 
HETATM 2146 C C15 . A1L0A C 3 .   ? 15.59000  -13.76500 -34.55900 1.000 46.36455 ? 500 A1L0A A C15 1 
HETATM 2147 C C16 . A1L0A C 3 .   ? 14.21000  -14.13500 -35.07400 1.000 45.59136 ? 500 A1L0A A C16 1 
HETATM 2148 C C17 . A1L0A C 3 .   ? 13.06700  -14.45300 -34.12500 1.000 46.04715 ? 500 A1L0A A C17 1 
HETATM 2149 C C18 . A1L0A C 3 .   ? 13.28700  -14.41700 -32.62600 1.000 47.60437 ? 500 A1L0A A C18 1 
HETATM 2150 C C19 . A1L0A C 3 .   ? 14.66300  -14.05100 -32.12000 1.000 44.73204 ? 500 A1L0A A C19 1 
HETATM 2151 C C26 . A1L0A C 3 .   ? 8.03300   -9.73300  -28.66600 1.000 37.18178 ? 500 A1L0A A C26 1 
HETATM 2152 C C27 . A1L0A C 3 .   ? 6.10200   -8.93400  -27.54000 1.000 38.34448 ? 500 A1L0A A C27 1 
HETATM 2153 C C28 . A1L0A C 3 .   ? 10.17200  -12.13000 -29.87200 1.000 39.85279 ? 500 A1L0A A C28 1 
HETATM 2154 C C29 . A1L0A C 3 .   ? 10.15400  -10.61700 -29.81600 1.000 39.06049 ? 500 A1L0A A C29 1 
HETATM 2155 C C31 . A1L0A C 3 .   ? 10.01200  -10.68000 -27.40600 1.000 37.79182 ? 500 A1L0A A C31 1 
HETATM 2156 C C32 . A1L0A C 3 .   ? 9.98900   -12.20300 -27.41200 1.000 35.84402 ? 500 A1L0A A C32 1 
HETATM 2157 C C35 . A1L0A C 3 .   ? 5.29200   -9.38000  -26.31100 1.000 38.87127 ? 500 A1L0A A C35 1 
HETATM 2158 C C36 . A1L0A C 3 .   ? 3.99100   -8.59200  -26.16800 1.000 40.11510 ? 500 A1L0A A C36 1 
HETATM 2159 C C37 . A1L0A C 3 .   ? 6.12500   -9.19900  -25.04500 1.000 37.96809 ? 500 A1L0A A C37 1 
HETATM 2160 F F20 . A1L0A C 3 .   ? 13.97700  -14.17200 -36.40400 1.000 49.49155 ? 500 A1L0A A F20 1 
HETATM 2161 N N07 . A1L0A C 3 .   ? 10.55300  -12.72800 -28.62000 1.000 42.38876 ? 500 A1L0A A N07 1 
HETATM 2162 N N21 . A1L0A C 3 .   ? 12.66600  -13.34300 -29.76900 1.000 42.24280 ? 500 A1L0A A N21 1 
HETATM 2163 N N22 . A1L0A C 3 .   ? 16.21500  -14.24700 -30.19900 1.000 50.78203 ? 500 A1L0A A N22 1 
HETATM 2164 N N23 . A1L0A C 3 .   ? 14.95200  -13.99900 -30.72800 1.000 46.69813 ? 500 A1L0A A N23 1 
HETATM 2165 N N30 . A1L0A C 3 .   ? 9.40600   -10.17200 -28.63100 1.000 39.05411 ? 500 A1L0A A N30 1 
HETATM 2166 O O24 . A1L0A C 3 .   ? 15.40100  -14.51800 -25.49000 1.000 44.62761 ? 500 A1L0A A O24 1 
HETATM 2167 O O25 . A1L0A C 3 .   ? 14.97700  -12.34000 -25.36900 1.000 44.73721 ? 500 A1L0A A O25 1 
HETATM 2168 O O33 . A1L0A C 3 .   ? 7.51900   -9.49200  -29.70400 1.000 36.28234 ? 500 A1L0A A O33 1 
HETATM 2169 O O34 . A1L0A C 3 .   ? 7.34900   -9.58400  -27.45400 1.000 36.82523 ? 500 A1L0A A O34 1 
HETATM 2170 O O   . HOH   D 4 .   ? 0.70100   0.82600   -41.13800 1.000 61.91854 ? 601 HOH   A O   1 
HETATM 2171 O O   . HOH   D 4 .   ? 3.52600   -28.92400 -19.70800 1.000 49.64416 ? 602 HOH   A O   1 
HETATM 2172 O O   . HOH   D 4 .   ? -5.03500  0.44200   -9.09300  1.000 57.07158 ? 603 HOH   A O   1 
HETATM 2173 O O   . HOH   D 4 .   ? 11.94300  -21.90700 -4.49700  1.000 50.03872 ? 604 HOH   A O   1 
HETATM 2174 O O   . HOH   D 4 .   ? -12.66800 -24.86300 -13.74100 1.000 51.62962 ? 605 HOH   A O   1 
HETATM 2175 O O   . HOH   D 4 .   ? 11.07000  -20.63900 -16.63700 1.000 44.62190 ? 606 HOH   A O   1 
HETATM 2176 O O   . HOH   D 4 .   ? 0.82400   -25.59600 -24.41300 1.000 52.01895 ? 607 HOH   A O   1 
HETATM 2177 O O   . HOH   D 4 .   ? 18.82500  -10.11900 1.71000   1.000 52.39531 ? 608 HOH   A O   1 
HETATM 2178 O O   . HOH   D 4 .   ? -9.47200  -5.32100  -30.00500 1.000 46.76506 ? 609 HOH   A O   1 
HETATM 2179 O O   . HOH   D 4 .   ? 24.95400  -20.86000 -35.47200 1.000 65.27440 ? 610 HOH   A O   1 
HETATM 2180 O O   . HOH   D 4 .   ? 4.53200   2.44400   -14.08900 1.000 53.25863 ? 611 HOH   A O   1 
HETATM 2181 O O   . HOH   D 4 .   ? 6.58800   -7.46600  -30.86500 1.000 39.33881 ? 612 HOH   A O   1 
HETATM 2182 O O   . HOH   D 4 .   ? 11.46900  -11.74600 0.36000   1.000 57.28518 ? 613 HOH   A O   1 
HETATM 2183 O O   . HOH   D 4 .   ? -7.62500  -15.50900 -28.38800 1.000 45.73019 ? 614 HOH   A O   1 
HETATM 2184 O O   . HOH   D 4 .   ? 4.12300   -4.64300  -4.24800  1.000 47.44682 ? 615 HOH   A O   1 
HETATM 2185 O O   . HOH   D 4 .   ? 23.96900  -15.22900 -19.75700 1.000 58.69213 ? 616 HOH   A O   1 
HETATM 2186 O O   . HOH   D 4 .   ? -5.57700  -12.12000 -36.86400 1.000 48.75200 ? 617 HOH   A O   1 
HETATM 2187 O O   . HOH   D 4 .   ? 22.02600  -25.19100 -26.82900 1.000 57.21311 ? 618 HOH   A O   1 
HETATM 2188 O O   . HOH   D 4 .   ? 4.91000   -0.14000  -10.37200 1.000 39.48827 ? 619 HOH   A O   1 
HETATM 2189 O O   . HOH   D 4 .   ? 3.55600   -16.54700 -42.59400 1.000 45.86183 ? 620 HOH   A O   1 
HETATM 2190 O O   . HOH   D 4 .   ? 8.83500   -15.90700 -10.83400 1.000 33.36651 ? 621 HOH   A O   1 
HETATM 2191 O O   . HOH   D 4 .   ? -2.86600  -1.43900  -9.45300  1.000 40.00517 ? 622 HOH   A O   1 
HETATM 2192 O O   . HOH   D 4 .   ? 7.01200   -4.79200  -24.84700 1.000 49.86640 ? 623 HOH   A O   1 
HETATM 2193 O O   . HOH   D 4 .   ? -8.61100  -8.12000  -23.77400 1.000 42.48253 ? 624 HOH   A O   1 
HETATM 2194 O O   . HOH   D 4 .   ? 1.99100   -7.11900  -23.23100 1.000 40.32057 ? 625 HOH   A O   1 
HETATM 2195 O O   . HOH   D 4 .   ? -3.99300  -14.90400 -25.62900 1.000 32.69667 ? 626 HOH   A O   1 
HETATM 2196 O O   . HOH   D 4 .   ? -1.09700  -9.67800  -23.42000 1.000 35.82222 ? 627 HOH   A O   1 
HETATM 2197 O O   . HOH   D 4 .   ? 2.53100   0.80200   -11.74700 1.000 50.18337 ? 628 HOH   A O   1 
HETATM 2198 O O   . HOH   D 4 .   ? -1.11700  -1.72000  -7.60100  1.000 52.92789 ? 629 HOH   A O   1 
HETATM 2199 O O   . HOH   D 4 .   ? 1.72000   -21.54100 -3.27400  1.000 55.25985 ? 630 HOH   A O   1 
HETATM 2200 O O   . HOH   D 4 .   ? 12.15600  -17.66600 -35.64200 1.000 52.58419 ? 631 HOH   A O   1 
HETATM 2201 O O   . HOH   D 4 .   ? 5.80700   -0.05400  -17.64000 1.000 43.38222 ? 632 HOH   A O   1 
HETATM 2202 O O   . HOH   D 4 .   ? -4.85000  -25.83500 -25.57200 1.000 49.44579 ? 633 HOH   A O   1 
HETATM 2203 O O   . HOH   D 4 .   ? -6.04200  -16.69200 -25.07900 1.000 38.61130 ? 634 HOH   A O   1 
HETATM 2204 O O   . HOH   D 4 .   ? 7.04500   -27.94000 -17.30600 1.000 43.64863 ? 635 HOH   A O   1 
HETATM 2205 O O   . HOH   D 4 .   ? -4.36800  1.38700   -14.86900 1.000 44.19999 ? 636 HOH   A O   1 
HETATM 2206 O O   . HOH   D 4 .   ? 11.09500  -22.31200 -27.23400 1.000 39.95419 ? 637 HOH   A O   1 
HETATM 2207 O O   . HOH   D 4 .   ? -12.50300 -21.59100 -11.92500 1.000 53.47828 ? 638 HOH   A O   1 
HETATM 2208 O O   . HOH   D 4 .   ? 3.99000   -4.80100  -23.79100 1.000 41.60313 ? 639 HOH   A O   1 
HETATM 2209 O O   . HOH   D 4 .   ? 8.52700   -5.68200  -31.29600 1.000 38.62863 ? 640 HOH   A O   1 
HETATM 2210 O O   . HOH   D 4 .   ? -3.96300  -26.63300 -21.25100 1.000 42.35207 ? 641 HOH   A O   1 
HETATM 2211 O O   . HOH   D 4 .   ? -7.15300  -22.10400 -6.01500  1.000 53.30228 ? 642 HOH   A O   1 
HETATM 2212 O O   . HOH   D 4 .   ? -1.76200  -2.93200  -21.26400 1.000 45.40801 ? 643 HOH   A O   1 
HETATM 2213 O O   . HOH   D 4 .   ? 12.72100  -15.92800 -17.13000 1.000 40.45569 ? 644 HOH   A O   1 
HETATM 2214 O O   . HOH   D 4 .   ? -14.35000 -20.95300 -16.08200 1.000 45.59973 ? 645 HOH   A O   1 
HETATM 2215 O O   . HOH   D 4 .   ? -8.02900  -3.89400  -40.47900 1.000 68.48165 ? 646 HOH   A O   1 
HETATM 2216 O O   . HOH   D 4 .   ? -5.31200  -20.85700 -4.45100  1.000 51.05871 ? 647 HOH   A O   1 
HETATM 2217 O O   . HOH   D 4 .   ? 0.77900   -23.76300 -35.40500 1.000 54.45220 ? 648 HOH   A O   1 
HETATM 2218 O O   . HOH   D 4 .   ? 1.36900   -25.80100 -13.35100 1.000 50.50392 ? 649 HOH   A O   1 
HETATM 2219 O O   . HOH   D 4 .   ? -1.74700  -13.80400 -24.33500 1.000 34.19022 ? 650 HOH   A O   1 
HETATM 2220 O O   . HOH   D 4 .   ? 2.30600   -3.90000  -46.05800 1.000 55.33535 ? 651 HOH   A O   1 
HETATM 2221 O O   . HOH   D 4 .   ? -9.90800  -9.69800  -6.09000  1.000 52.20832 ? 652 HOH   A O   1 
HETATM 2222 O O   . HOH   D 4 .   ? -4.46200  -0.77800  -31.60700 1.000 40.62911 ? 653 HOH   A O   1 
HETATM 2223 O O   . HOH   D 4 .   ? 12.276    6.591     -37.917   1.000 51.98064 ? 654 HOH   A O   1 
HETATM 2224 O O   . HOH   D 4 .   ? 8.05900   -18.90800 -37.91800 1.000 42.48315 ? 655 HOH   A O   1 
HETATM 2225 O O   . HOH   D 4 .   ? -4.86000  -16.93400 -35.86300 1.000 52.07685 ? 656 HOH   A O   1 
HETATM 2226 O O   . HOH   D 4 .   ? 4.20600   -4.67400  -31.47300 1.000 43.22348 ? 657 HOH   A O   1 
HETATM 2227 O O   . HOH   D 4 .   ? 7.32600   -3.42500  -30.06200 1.000 45.90262 ? 658 HOH   A O   1 
HETATM 2228 O O   . HOH   D 4 .   ? -5.88600  -1.03100  -23.57700 1.000 56.02597 ? 659 HOH   A O   1 
HETATM 2229 O O   . HOH   D 4 .   ? 5.36400   -25.12900 -28.49000 1.000 47.12726 ? 660 HOH   A O   1 
HETATM 2230 O O   . HOH   D 4 .   ? 10.37100  -19.21900 -36.89200 1.000 51.30931 ? 661 HOH   A O   1 
HETATM 2231 O O   . HOH   D 4 .   ? -10.27400 -7.87800  -20.39700 1.000 43.98990 ? 662 HOH   A O   1 
HETATM 2232 O O   . HOH   D 4 .   ? 20.16800  -11.02700 -6.09400  1.000 49.14198 ? 663 HOH   A O   1 
HETATM 2233 O O   . HOH   D 4 .   ? 5.77400   -26.09100 -24.39100 1.000 48.06720 ? 664 HOH   A O   1 
HETATM 2234 O O   . HOH   D 4 .   ? 4.66500   -17.71800 -27.42200 1.000 40.17585 ? 665 HOH   A O   1 
HETATM 2235 O O   . HOH   D 4 .   ? -6.07000  -19.64400 -32.24700 1.000 50.50807 ? 666 HOH   A O   1 
HETATM 2236 O O   . HOH   D 4 .   ? 0.74000   -8.51800  -25.18600 1.000 38.15393 ? 667 HOH   A O   1 
HETATM 2237 O O   . HOH   D 4 .   ? 0.19500   1.14900   -33.13200 1.000 51.47097 ? 668 HOH   A O   1 
HETATM 2238 O O   . HOH   D 4 .   ? 11.71900  -21.97200 -11.93500 1.000 48.08404 ? 669 HOH   A O   1 
HETATM 2239 O O   . HOH   D 4 .   ? -12.57900 -22.19000 -14.85100 1.000 51.56022 ? 670 HOH   A O   1 
HETATM 2240 O O   . HOH   D 4 .   ? 10.86500  -14.55700 -48.09700 1.000 51.66351 ? 671 HOH   A O   1 
HETATM 2241 O O   . HOH   D 4 .   ? 18.70700  -12.73700 0.97500   1.000 59.26540 ? 672 HOH   A O   1 
HETATM 2242 O O   . HOH   D 4 .   ? 9.16300   -15.70700 -46.85900 1.000 57.58784 ? 673 HOH   A O   1 
HETATM 2243 O O   . HOH   D 4 .   ? -4.72000  -16.83300 -32.81900 1.000 49.32294 ? 674 HOH   A O   1 
HETATM 2244 O O   . HOH   D 4 .   ? -1.68500  0.31800   -11.15300 1.000 49.57298 ? 675 HOH   A O   1 
HETATM 2245 O O   . HOH   D 4 .   ? -8.41700  -18.73800 -31.58200 1.000 56.50552 ? 676 HOH   A O   1 
HETATM 2246 O O   . HOH   D 4 .   ? -8.74700  -9.09000  -26.54300 1.000 50.75649 ? 677 HOH   A O   1 
HETATM 2247 O O   . HOH   D 4 .   ? 1.66600   -30.44300 -18.35200 1.000 50.87007 ? 678 HOH   A O   1 
HETATM 2248 O O   . HOH   D 4 .   ? -9.01000  -2.37800  -38.41800 1.000 63.76719 ? 679 HOH   A O   1 
HETATM 2249 O O   . HOH   D 4 .   ? 5.868     -29.959   -19.133   1.000 50.25992 ? 680 HOH   A O   1 
HETATM 2250 O O   . HOH   D 4 .   ? 0.49800   1.08900   -9.87700  1.000 47.04199 ? 681 HOH   A O   1 
HETATM 2251 O O   . HOH   D 4 .   ? -11.87900 -10.98500 -7.03700  1.000 55.34476 ? 682 HOH   A O   1 
HETATM 2252 O O   . HOH   D 4 .   ? 1.21500   0.45200   -7.57400  1.000 51.66594 ? 683 HOH   A O   1 
HETATM 2253 O O   . HOH   D 4 .   ? -1.62400  1.40500   -34.72100 1.000 54.09215 ? 684 HOH   A O   1 
HETATM 2254 O O   . HOH   D 4 .   ? 3.314     -28.007   -37.442   1.000 57.25109 ? 685 HOH   A O   1 
HETATM 2255 O O   . HOH   D 4 .   ? 17.65100  -1.88200  -27.04300 1.000 57.02433 ? 686 HOH   A O   1 
HETATM 2256 O O   . HOH   D 4 .   ? 11.85900  -6.01100  -37.43800 1.000 52.64070 ? 687 HOH   A O   1 
HETATM 2257 O O   . HOH   D 4 .   ? 12.13100  -3.69900  -37.14700 1.000 55.18244 ? 688 HOH   A O   1 
HETATM 2258 O O   . HOH   E 4 .   ? 19.17300  -1.79100  -15.16900 1.000 53.96341 ? 201 HOH   B O   1 
# 
