data_8YWU
# 
_entry.id   8YWU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YWU         pdb_00008ywu 10.2210/pdb8ywu/pdb 
WWPDB D_1300046543 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-09 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YWU 
_pdbx_database_status.recvd_initial_deposition_date   2024-04-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          8YT6 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yo@phs.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Takuya 
_pdbx_contact_author.name_last          Yoshida 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3491-9344 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tachibana, K.' 1  ? 
'Morie, T.'     2  ? 
'Fukuda, S.'    3  ? 
'Yuzuriha, T.'  4  ? 
'Ishimoto, K.'  5  ? 
'Nunomura, K.'  6  ? 
'Lin, B.'       7  ? 
'Miyachi, H.'   8  ? 
'Oki, H.'       9  ? 
'Kawahara, K.'  10 ? 
'Meguro, K.'    11 ? 
'Nakagawa, S.'  12 ? 
'Tsujikawa, K.' 13 ? 
'Akai, S.'      14 ? 
'Doi, T.'       15 ? 
'Yoshida, T.'   16 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural evolution of 1H-pyrazolo[3,4-b]pyridine-derived PPARalpha activators as leads for nonalcoholic steatohepatitis' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tachibana, K.' 1  ? 
primary 'Morie, T.'     2  ? 
primary 'Fukuda, S.'    3  ? 
primary 'Yuzuriha, T.'  4  ? 
primary 'Ishimoto, K.'  5  ? 
primary 'Nunomura, K.'  6  ? 
primary 'Lin, B.'       7  ? 
primary 'Miyachi, H.'   8  ? 
primary 'Oki, H.'       9  ? 
primary 'Kawahara, K.'  10 ? 
primary 'Meguro, K.'    11 ? 
primary 'Nakagawa, S.'  12 ? 
primary 'Tsujikawa, K.' 13 ? 
primary 'Akai, S.'      14 ? 
primary 'Doi, T.'       15 ? 
primary 'Yoshida, T.'   16 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peroxisome proliferator-activated receptor alpha' 30684.814 1   ? ? ? ? 
2 polymer     syn 'Peroxisome proliferator-activated receptor gamma coactivator 1-alpha' 2405.782  1   ? ? ? ? 
3 non-polymer syn 
'1-(4-fluorophenyl)-6-[2-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]ethyl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
542.601   1   ? ? ? ? 
4 water       nat water 18.015    184 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'PPAR-alpha,Nuclear receptor subfamily 1 group C member 1'                            
2 'PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
A ? 
2 'polypeptide(L)' no no PQEAEEPSLLKKLLLAPANTQL PQEAEEPSLLKKLLLAPANTQL B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 
'1-(4-fluorophenyl)-6-[2-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]ethyl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
A1LZ9 
4 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   GLY n 
1 3   GLN n 
1 4   THR n 
1 5   ALA n 
1 6   ASP n 
1 7   LEU n 
1 8   LYS n 
1 9   SER n 
1 10  LEU n 
1 11  ALA n 
1 12  LYS n 
1 13  ARG n 
1 14  ILE n 
1 15  TYR n 
1 16  GLU n 
1 17  ALA n 
1 18  TYR n 
1 19  LEU n 
1 20  LYS n 
1 21  ASN n 
1 22  PHE n 
1 23  ASN n 
1 24  MET n 
1 25  ASN n 
1 26  LYS n 
1 27  VAL n 
1 28  LYS n 
1 29  ALA n 
1 30  ARG n 
1 31  VAL n 
1 32  ILE n 
1 33  LEU n 
1 34  SER n 
1 35  GLY n 
1 36  LYS n 
1 37  ALA n 
1 38  SER n 
1 39  ASN n 
1 40  ASN n 
1 41  PRO n 
1 42  PRO n 
1 43  PHE n 
1 44  VAL n 
1 45  ILE n 
1 46  HIS n 
1 47  ASP n 
1 48  MET n 
1 49  GLU n 
1 50  THR n 
1 51  LEU n 
1 52  CYS n 
1 53  MET n 
1 54  ALA n 
1 55  GLU n 
1 56  LYS n 
1 57  THR n 
1 58  LEU n 
1 59  VAL n 
1 60  ALA n 
1 61  LYS n 
1 62  LEU n 
1 63  VAL n 
1 64  ALA n 
1 65  ASN n 
1 66  GLY n 
1 67  ILE n 
1 68  GLN n 
1 69  ASN n 
1 70  LYS n 
1 71  GLU n 
1 72  ALA n 
1 73  GLU n 
1 74  VAL n 
1 75  ARG n 
1 76  ILE n 
1 77  PHE n 
1 78  HIS n 
1 79  CYS n 
1 80  CYS n 
1 81  GLN n 
1 82  CYS n 
1 83  THR n 
1 84  SER n 
1 85  VAL n 
1 86  GLU n 
1 87  THR n 
1 88  VAL n 
1 89  THR n 
1 90  GLU n 
1 91  LEU n 
1 92  THR n 
1 93  GLU n 
1 94  PHE n 
1 95  ALA n 
1 96  LYS n 
1 97  ALA n 
1 98  ILE n 
1 99  PRO n 
1 100 GLY n 
1 101 PHE n 
1 102 ALA n 
1 103 ASN n 
1 104 LEU n 
1 105 ASP n 
1 106 LEU n 
1 107 ASN n 
1 108 ASP n 
1 109 GLN n 
1 110 VAL n 
1 111 THR n 
1 112 LEU n 
1 113 LEU n 
1 114 LYS n 
1 115 TYR n 
1 116 GLY n 
1 117 VAL n 
1 118 TYR n 
1 119 GLU n 
1 120 ALA n 
1 121 ILE n 
1 122 PHE n 
1 123 ALA n 
1 124 MET n 
1 125 LEU n 
1 126 SER n 
1 127 SER n 
1 128 VAL n 
1 129 MET n 
1 130 ASN n 
1 131 LYS n 
1 132 ASP n 
1 133 GLY n 
1 134 MET n 
1 135 LEU n 
1 136 VAL n 
1 137 ALA n 
1 138 TYR n 
1 139 GLY n 
1 140 ASN n 
1 141 GLY n 
1 142 PHE n 
1 143 ILE n 
1 144 THR n 
1 145 ARG n 
1 146 GLU n 
1 147 PHE n 
1 148 LEU n 
1 149 LYS n 
1 150 SER n 
1 151 LEU n 
1 152 ARG n 
1 153 LYS n 
1 154 PRO n 
1 155 PHE n 
1 156 CYS n 
1 157 ASP n 
1 158 ILE n 
1 159 MET n 
1 160 GLU n 
1 161 PRO n 
1 162 LYS n 
1 163 PHE n 
1 164 ASP n 
1 165 PHE n 
1 166 ALA n 
1 167 MET n 
1 168 LYS n 
1 169 PHE n 
1 170 ASN n 
1 171 ALA n 
1 172 LEU n 
1 173 GLU n 
1 174 LEU n 
1 175 ASP n 
1 176 ASP n 
1 177 SER n 
1 178 ASP n 
1 179 ILE n 
1 180 SER n 
1 181 LEU n 
1 182 PHE n 
1 183 VAL n 
1 184 ALA n 
1 185 ALA n 
1 186 ILE n 
1 187 ILE n 
1 188 CYS n 
1 189 CYS n 
1 190 GLY n 
1 191 ASP n 
1 192 ARG n 
1 193 PRO n 
1 194 GLY n 
1 195 LEU n 
1 196 LEU n 
1 197 ASN n 
1 198 VAL n 
1 199 GLY n 
1 200 HIS n 
1 201 ILE n 
1 202 GLU n 
1 203 LYS n 
1 204 MET n 
1 205 GLN n 
1 206 GLU n 
1 207 GLY n 
1 208 ILE n 
1 209 VAL n 
1 210 HIS n 
1 211 VAL n 
1 212 LEU n 
1 213 ARG n 
1 214 LEU n 
1 215 HIS n 
1 216 LEU n 
1 217 GLN n 
1 218 SER n 
1 219 ASN n 
1 220 HIS n 
1 221 PRO n 
1 222 ASP n 
1 223 ASP n 
1 224 ILE n 
1 225 PHE n 
1 226 LEU n 
1 227 PHE n 
1 228 PRO n 
1 229 LYS n 
1 230 LEU n 
1 231 LEU n 
1 232 GLN n 
1 233 LYS n 
1 234 MET n 
1 235 ALA n 
1 236 ASP n 
1 237 LEU n 
1 238 ARG n 
1 239 GLN n 
1 240 LEU n 
1 241 VAL n 
1 242 THR n 
1 243 GLU n 
1 244 HIS n 
1 245 ALA n 
1 246 GLN n 
1 247 LEU n 
1 248 VAL n 
1 249 GLN n 
1 250 ILE n 
1 251 ILE n 
1 252 LYS n 
1 253 LYS n 
1 254 THR n 
1 255 GLU n 
1 256 SER n 
1 257 ASP n 
1 258 ALA n 
1 259 ALA n 
1 260 LEU n 
1 261 HIS n 
1 262 PRO n 
1 263 LEU n 
1 264 LEU n 
1 265 GLN n 
1 266 GLU n 
1 267 ILE n 
1 268 TYR n 
1 269 ARG n 
1 270 ASP n 
1 271 MET n 
1 272 TYR n 
2 1   PRO n 
2 2   GLN n 
2 3   GLU n 
2 4   ALA n 
2 5   GLU n 
2 6   GLU n 
2 7   PRO n 
2 8   SER n 
2 9   LEU n 
2 10  LEU n 
2 11  LYS n 
2 12  LYS n 
2 13  LEU n 
2 14  LEU n 
2 15  LEU n 
2 16  ALA n 
2 17  PRO n 
2 18  ALA n 
2 19  ASN n 
2 20  THR n 
2 21  GLN n 
2 22  LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   272 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PPARA, NR1C1, PPAR' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       22 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1LZ9 non-polymer         . 
'1-(4-fluorophenyl)-6-[2-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]ethyl]-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
? 'C31 H31 F N4 O4' 542.601 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   197 ?   ?   ?   A . n 
A 1 2   GLY 2   198 ?   ?   ?   A . n 
A 1 3   GLN 3   199 ?   ?   ?   A . n 
A 1 4   THR 4   200 ?   ?   ?   A . n 
A 1 5   ALA 5   201 ?   ?   ?   A . n 
A 1 6   ASP 6   202 ?   ?   ?   A . n 
A 1 7   LEU 7   203 ?   ?   ?   A . n 
A 1 8   LYS 8   204 ?   ?   ?   A . n 
A 1 9   SER 9   205 205 SER SER A . n 
A 1 10  LEU 10  206 206 LEU LEU A . n 
A 1 11  ALA 11  207 207 ALA ALA A . n 
A 1 12  LYS 12  208 208 LYS LYS A . n 
A 1 13  ARG 13  209 209 ARG ARG A . n 
A 1 14  ILE 14  210 210 ILE ILE A . n 
A 1 15  TYR 15  211 211 TYR TYR A . n 
A 1 16  GLU 16  212 212 GLU GLU A . n 
A 1 17  ALA 17  213 213 ALA ALA A . n 
A 1 18  TYR 18  214 214 TYR TYR A . n 
A 1 19  LEU 19  215 215 LEU LEU A . n 
A 1 20  LYS 20  216 216 LYS LYS A . n 
A 1 21  ASN 21  217 217 ASN ASN A . n 
A 1 22  PHE 22  218 218 PHE PHE A . n 
A 1 23  ASN 23  219 219 ASN ASN A . n 
A 1 24  MET 24  220 220 MET MET A . n 
A 1 25  ASN 25  221 221 ASN ASN A . n 
A 1 26  LYS 26  222 222 LYS LYS A . n 
A 1 27  VAL 27  223 223 VAL VAL A . n 
A 1 28  LYS 28  224 224 LYS LYS A . n 
A 1 29  ALA 29  225 225 ALA ALA A . n 
A 1 30  ARG 30  226 226 ARG ARG A . n 
A 1 31  VAL 31  227 227 VAL VAL A . n 
A 1 32  ILE 32  228 228 ILE ILE A . n 
A 1 33  LEU 33  229 229 LEU LEU A . n 
A 1 34  SER 34  230 230 SER SER A . n 
A 1 35  GLY 35  231 ?   ?   ?   A . n 
A 1 36  LYS 36  232 ?   ?   ?   A . n 
A 1 37  ALA 37  233 ?   ?   ?   A . n 
A 1 38  SER 38  234 ?   ?   ?   A . n 
A 1 39  ASN 39  235 ?   ?   ?   A . n 
A 1 40  ASN 40  236 ?   ?   ?   A . n 
A 1 41  PRO 41  237 237 PRO PRO A . n 
A 1 42  PRO 42  238 238 PRO PRO A . n 
A 1 43  PHE 43  239 239 PHE PHE A . n 
A 1 44  VAL 44  240 240 VAL VAL A . n 
A 1 45  ILE 45  241 241 ILE ILE A . n 
A 1 46  HIS 46  242 242 HIS HIS A . n 
A 1 47  ASP 47  243 243 ASP ASP A . n 
A 1 48  MET 48  244 244 MET MET A . n 
A 1 49  GLU 49  245 245 GLU GLU A . n 
A 1 50  THR 50  246 246 THR THR A . n 
A 1 51  LEU 51  247 247 LEU LEU A . n 
A 1 52  CYS 52  248 248 CYS CYS A . n 
A 1 53  MET 53  249 249 MET MET A . n 
A 1 54  ALA 54  250 250 ALA ALA A . n 
A 1 55  GLU 55  251 251 GLU GLU A . n 
A 1 56  LYS 56  252 252 LYS LYS A . n 
A 1 57  THR 57  253 253 THR THR A . n 
A 1 58  LEU 58  254 254 LEU LEU A . n 
A 1 59  VAL 59  255 255 VAL VAL A . n 
A 1 60  ALA 60  256 256 ALA ALA A . n 
A 1 61  LYS 61  257 257 LYS LYS A . n 
A 1 62  LEU 62  258 258 LEU LEU A . n 
A 1 63  VAL 63  259 ?   ?   ?   A . n 
A 1 64  ALA 64  260 ?   ?   ?   A . n 
A 1 65  ASN 65  261 ?   ?   ?   A . n 
A 1 66  GLY 66  262 ?   ?   ?   A . n 
A 1 67  ILE 67  263 ?   ?   ?   A . n 
A 1 68  GLN 68  264 ?   ?   ?   A . n 
A 1 69  ASN 69  265 265 ASN ASN A . n 
A 1 70  LYS 70  266 266 LYS LYS A . n 
A 1 71  GLU 71  267 267 GLU GLU A . n 
A 1 72  ALA 72  268 268 ALA ALA A . n 
A 1 73  GLU 73  269 269 GLU GLU A . n 
A 1 74  VAL 74  270 270 VAL VAL A . n 
A 1 75  ARG 75  271 271 ARG ARG A . n 
A 1 76  ILE 76  272 272 ILE ILE A . n 
A 1 77  PHE 77  273 273 PHE PHE A . n 
A 1 78  HIS 78  274 274 HIS HIS A . n 
A 1 79  CYS 79  275 275 CYS CYS A . n 
A 1 80  CYS 80  276 276 CYS CYS A . n 
A 1 81  GLN 81  277 277 GLN GLN A . n 
A 1 82  CYS 82  278 278 CYS CYS A . n 
A 1 83  THR 83  279 279 THR THR A . n 
A 1 84  SER 84  280 280 SER SER A . n 
A 1 85  VAL 85  281 281 VAL VAL A . n 
A 1 86  GLU 86  282 282 GLU GLU A . n 
A 1 87  THR 87  283 283 THR THR A . n 
A 1 88  VAL 88  284 284 VAL VAL A . n 
A 1 89  THR 89  285 285 THR THR A . n 
A 1 90  GLU 90  286 286 GLU GLU A . n 
A 1 91  LEU 91  287 287 LEU LEU A . n 
A 1 92  THR 92  288 288 THR THR A . n 
A 1 93  GLU 93  289 289 GLU GLU A . n 
A 1 94  PHE 94  290 290 PHE PHE A . n 
A 1 95  ALA 95  291 291 ALA ALA A . n 
A 1 96  LYS 96  292 292 LYS LYS A . n 
A 1 97  ALA 97  293 293 ALA ALA A . n 
A 1 98  ILE 98  294 294 ILE ILE A . n 
A 1 99  PRO 99  295 295 PRO PRO A . n 
A 1 100 GLY 100 296 296 GLY GLY A . n 
A 1 101 PHE 101 297 297 PHE PHE A . n 
A 1 102 ALA 102 298 298 ALA ALA A . n 
A 1 103 ASN 103 299 299 ASN ASN A . n 
A 1 104 LEU 104 300 300 LEU LEU A . n 
A 1 105 ASP 105 301 301 ASP ASP A . n 
A 1 106 LEU 106 302 302 LEU LEU A . n 
A 1 107 ASN 107 303 303 ASN ASN A . n 
A 1 108 ASP 108 304 304 ASP ASP A . n 
A 1 109 GLN 109 305 305 GLN GLN A . n 
A 1 110 VAL 110 306 306 VAL VAL A . n 
A 1 111 THR 111 307 307 THR THR A . n 
A 1 112 LEU 112 308 308 LEU LEU A . n 
A 1 113 LEU 113 309 309 LEU LEU A . n 
A 1 114 LYS 114 310 310 LYS LYS A . n 
A 1 115 TYR 115 311 311 TYR TYR A . n 
A 1 116 GLY 116 312 312 GLY GLY A . n 
A 1 117 VAL 117 313 313 VAL VAL A . n 
A 1 118 TYR 118 314 314 TYR TYR A . n 
A 1 119 GLU 119 315 315 GLU GLU A . n 
A 1 120 ALA 120 316 316 ALA ALA A . n 
A 1 121 ILE 121 317 317 ILE ILE A . n 
A 1 122 PHE 122 318 318 PHE PHE A . n 
A 1 123 ALA 123 319 319 ALA ALA A . n 
A 1 124 MET 124 320 320 MET MET A . n 
A 1 125 LEU 125 321 321 LEU LEU A . n 
A 1 126 SER 126 322 322 SER SER A . n 
A 1 127 SER 127 323 323 SER SER A . n 
A 1 128 VAL 128 324 324 VAL VAL A . n 
A 1 129 MET 129 325 325 MET MET A . n 
A 1 130 ASN 130 326 326 ASN ASN A . n 
A 1 131 LYS 131 327 327 LYS LYS A . n 
A 1 132 ASP 132 328 328 ASP ASP A . n 
A 1 133 GLY 133 329 329 GLY GLY A . n 
A 1 134 MET 134 330 330 MET MET A . n 
A 1 135 LEU 135 331 331 LEU LEU A . n 
A 1 136 VAL 136 332 332 VAL VAL A . n 
A 1 137 ALA 137 333 333 ALA ALA A . n 
A 1 138 TYR 138 334 334 TYR TYR A . n 
A 1 139 GLY 139 335 335 GLY GLY A . n 
A 1 140 ASN 140 336 336 ASN ASN A . n 
A 1 141 GLY 141 337 337 GLY GLY A . n 
A 1 142 PHE 142 338 338 PHE PHE A . n 
A 1 143 ILE 143 339 339 ILE ILE A . n 
A 1 144 THR 144 340 340 THR THR A . n 
A 1 145 ARG 145 341 341 ARG ARG A . n 
A 1 146 GLU 146 342 342 GLU GLU A . n 
A 1 147 PHE 147 343 343 PHE PHE A . n 
A 1 148 LEU 148 344 344 LEU LEU A . n 
A 1 149 LYS 149 345 345 LYS LYS A . n 
A 1 150 SER 150 346 346 SER SER A . n 
A 1 151 LEU 151 347 347 LEU LEU A . n 
A 1 152 ARG 152 348 348 ARG ARG A . n 
A 1 153 LYS 153 349 349 LYS LYS A . n 
A 1 154 PRO 154 350 350 PRO PRO A . n 
A 1 155 PHE 155 351 351 PHE PHE A . n 
A 1 156 CYS 156 352 352 CYS CYS A . n 
A 1 157 ASP 157 353 353 ASP ASP A . n 
A 1 158 ILE 158 354 354 ILE ILE A . n 
A 1 159 MET 159 355 355 MET MET A . n 
A 1 160 GLU 160 356 356 GLU GLU A . n 
A 1 161 PRO 161 357 357 PRO PRO A . n 
A 1 162 LYS 162 358 358 LYS LYS A . n 
A 1 163 PHE 163 359 359 PHE PHE A . n 
A 1 164 ASP 164 360 360 ASP ASP A . n 
A 1 165 PHE 165 361 361 PHE PHE A . n 
A 1 166 ALA 166 362 362 ALA ALA A . n 
A 1 167 MET 167 363 363 MET MET A . n 
A 1 168 LYS 168 364 364 LYS LYS A . n 
A 1 169 PHE 169 365 365 PHE PHE A . n 
A 1 170 ASN 170 366 366 ASN ASN A . n 
A 1 171 ALA 171 367 367 ALA ALA A . n 
A 1 172 LEU 172 368 368 LEU LEU A . n 
A 1 173 GLU 173 369 369 GLU GLU A . n 
A 1 174 LEU 174 370 370 LEU LEU A . n 
A 1 175 ASP 175 371 371 ASP ASP A . n 
A 1 176 ASP 176 372 372 ASP ASP A . n 
A 1 177 SER 177 373 373 SER SER A . n 
A 1 178 ASP 178 374 374 ASP ASP A . n 
A 1 179 ILE 179 375 375 ILE ILE A . n 
A 1 180 SER 180 376 376 SER SER A . n 
A 1 181 LEU 181 377 377 LEU LEU A . n 
A 1 182 PHE 182 378 378 PHE PHE A . n 
A 1 183 VAL 183 379 379 VAL VAL A . n 
A 1 184 ALA 184 380 380 ALA ALA A . n 
A 1 185 ALA 185 381 381 ALA ALA A . n 
A 1 186 ILE 186 382 382 ILE ILE A . n 
A 1 187 ILE 187 383 383 ILE ILE A . n 
A 1 188 CYS 188 384 384 CYS CYS A . n 
A 1 189 CYS 189 385 385 CYS CYS A . n 
A 1 190 GLY 190 386 386 GLY GLY A . n 
A 1 191 ASP 191 387 387 ASP ASP A . n 
A 1 192 ARG 192 388 388 ARG ARG A . n 
A 1 193 PRO 193 389 389 PRO PRO A . n 
A 1 194 GLY 194 390 390 GLY GLY A . n 
A 1 195 LEU 195 391 391 LEU LEU A . n 
A 1 196 LEU 196 392 392 LEU LEU A . n 
A 1 197 ASN 197 393 393 ASN ASN A . n 
A 1 198 VAL 198 394 394 VAL VAL A . n 
A 1 199 GLY 199 395 395 GLY GLY A . n 
A 1 200 HIS 200 396 396 HIS HIS A . n 
A 1 201 ILE 201 397 397 ILE ILE A . n 
A 1 202 GLU 202 398 398 GLU GLU A . n 
A 1 203 LYS 203 399 399 LYS LYS A . n 
A 1 204 MET 204 400 400 MET MET A . n 
A 1 205 GLN 205 401 401 GLN GLN A . n 
A 1 206 GLU 206 402 402 GLU GLU A . n 
A 1 207 GLY 207 403 403 GLY GLY A . n 
A 1 208 ILE 208 404 404 ILE ILE A . n 
A 1 209 VAL 209 405 405 VAL VAL A . n 
A 1 210 HIS 210 406 406 HIS HIS A . n 
A 1 211 VAL 211 407 407 VAL VAL A . n 
A 1 212 LEU 212 408 408 LEU LEU A . n 
A 1 213 ARG 213 409 409 ARG ARG A . n 
A 1 214 LEU 214 410 410 LEU LEU A . n 
A 1 215 HIS 215 411 411 HIS HIS A . n 
A 1 216 LEU 216 412 412 LEU LEU A . n 
A 1 217 GLN 217 413 413 GLN GLN A . n 
A 1 218 SER 218 414 414 SER SER A . n 
A 1 219 ASN 219 415 415 ASN ASN A . n 
A 1 220 HIS 220 416 416 HIS HIS A . n 
A 1 221 PRO 221 417 417 PRO PRO A . n 
A 1 222 ASP 222 418 418 ASP ASP A . n 
A 1 223 ASP 223 419 419 ASP ASP A . n 
A 1 224 ILE 224 420 420 ILE ILE A . n 
A 1 225 PHE 225 421 421 PHE PHE A . n 
A 1 226 LEU 226 422 422 LEU LEU A . n 
A 1 227 PHE 227 423 423 PHE PHE A . n 
A 1 228 PRO 228 424 424 PRO PRO A . n 
A 1 229 LYS 229 425 425 LYS LYS A . n 
A 1 230 LEU 230 426 426 LEU LEU A . n 
A 1 231 LEU 231 427 427 LEU LEU A . n 
A 1 232 GLN 232 428 428 GLN GLN A . n 
A 1 233 LYS 233 429 429 LYS LYS A . n 
A 1 234 MET 234 430 430 MET MET A . n 
A 1 235 ALA 235 431 431 ALA ALA A . n 
A 1 236 ASP 236 432 432 ASP ASP A . n 
A 1 237 LEU 237 433 433 LEU LEU A . n 
A 1 238 ARG 238 434 434 ARG ARG A . n 
A 1 239 GLN 239 435 435 GLN GLN A . n 
A 1 240 LEU 240 436 436 LEU LEU A . n 
A 1 241 VAL 241 437 437 VAL VAL A . n 
A 1 242 THR 242 438 438 THR THR A . n 
A 1 243 GLU 243 439 439 GLU GLU A . n 
A 1 244 HIS 244 440 440 HIS HIS A . n 
A 1 245 ALA 245 441 441 ALA ALA A . n 
A 1 246 GLN 246 442 442 GLN GLN A . n 
A 1 247 LEU 247 443 443 LEU LEU A . n 
A 1 248 VAL 248 444 444 VAL VAL A . n 
A 1 249 GLN 249 445 445 GLN GLN A . n 
A 1 250 ILE 250 446 446 ILE ILE A . n 
A 1 251 ILE 251 447 447 ILE ILE A . n 
A 1 252 LYS 252 448 448 LYS LYS A . n 
A 1 253 LYS 253 449 449 LYS LYS A . n 
A 1 254 THR 254 450 450 THR THR A . n 
A 1 255 GLU 255 451 451 GLU GLU A . n 
A 1 256 SER 256 452 452 SER SER A . n 
A 1 257 ASP 257 453 453 ASP ASP A . n 
A 1 258 ALA 258 454 454 ALA ALA A . n 
A 1 259 ALA 259 455 455 ALA ALA A . n 
A 1 260 LEU 260 456 456 LEU LEU A . n 
A 1 261 HIS 261 457 457 HIS HIS A . n 
A 1 262 PRO 262 458 458 PRO PRO A . n 
A 1 263 LEU 263 459 459 LEU LEU A . n 
A 1 264 LEU 264 460 460 LEU LEU A . n 
A 1 265 GLN 265 461 461 GLN GLN A . n 
A 1 266 GLU 266 462 462 GLU GLU A . n 
A 1 267 ILE 267 463 463 ILE ILE A . n 
A 1 268 TYR 268 464 464 TYR TYR A . n 
A 1 269 ARG 269 465 465 ARG ARG A . n 
A 1 270 ASP 270 466 466 ASP ASP A . n 
A 1 271 MET 271 467 467 MET MET A . n 
A 1 272 TYR 272 468 468 TYR TYR A . n 
B 2 1   PRO 1   135 ?   ?   ?   B . n 
B 2 2   GLN 2   136 ?   ?   ?   B . n 
B 2 3   GLU 3   137 ?   ?   ?   B . n 
B 2 4   ALA 4   138 ?   ?   ?   B . n 
B 2 5   GLU 5   139 ?   ?   ?   B . n 
B 2 6   GLU 6   140 ?   ?   ?   B . n 
B 2 7   PRO 7   141 141 PRO PRO B . n 
B 2 8   SER 8   142 142 SER SER B . n 
B 2 9   LEU 9   143 143 LEU LEU B . n 
B 2 10  LEU 10  144 144 LEU LEU B . n 
B 2 11  LYS 11  145 145 LYS LYS B . n 
B 2 12  LYS 12  146 146 LYS LYS B . n 
B 2 13  LEU 13  147 147 LEU LEU B . n 
B 2 14  LEU 14  148 148 LEU LEU B . n 
B 2 15  LEU 15  149 149 LEU LEU B . n 
B 2 16  ALA 16  150 150 ALA ALA B . n 
B 2 17  PRO 17  151 ?   ?   ?   B . n 
B 2 18  ALA 18  152 ?   ?   ?   B . n 
B 2 19  ASN 19  153 ?   ?   ?   B . n 
B 2 20  THR 20  154 ?   ?   ?   B . n 
B 2 21  GLN 21  155 ?   ?   ?   B . n 
B 2 22  LEU 22  156 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1LZ9 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1LZ9 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1LZ9 1   500 500 A1LZ9 A05 A . 
D 4 HOH   1   601 165 HOH   HOH A . 
D 4 HOH   2   602 162 HOH   HOH A . 
D 4 HOH   3   603 96  HOH   HOH A . 
D 4 HOH   4   604 182 HOH   HOH A . 
D 4 HOH   5   605 111 HOH   HOH A . 
D 4 HOH   6   606 130 HOH   HOH A . 
D 4 HOH   7   607 39  HOH   HOH A . 
D 4 HOH   8   608 42  HOH   HOH A . 
D 4 HOH   9   609 104 HOH   HOH A . 
D 4 HOH   10  610 125 HOH   HOH A . 
D 4 HOH   11  611 77  HOH   HOH A . 
D 4 HOH   12  612 29  HOH   HOH A . 
D 4 HOH   13  613 119 HOH   HOH A . 
D 4 HOH   14  614 31  HOH   HOH A . 
D 4 HOH   15  615 33  HOH   HOH A . 
D 4 HOH   16  616 58  HOH   HOH A . 
D 4 HOH   17  617 95  HOH   HOH A . 
D 4 HOH   18  618 19  HOH   HOH A . 
D 4 HOH   19  619 85  HOH   HOH A . 
D 4 HOH   20  620 113 HOH   HOH A . 
D 4 HOH   21  621 78  HOH   HOH A . 
D 4 HOH   22  622 17  HOH   HOH A . 
D 4 HOH   23  623 143 HOH   HOH A . 
D 4 HOH   24  624 4   HOH   HOH A . 
D 4 HOH   25  625 44  HOH   HOH A . 
D 4 HOH   26  626 36  HOH   HOH A . 
D 4 HOH   27  627 23  HOH   HOH A . 
D 4 HOH   28  628 65  HOH   HOH A . 
D 4 HOH   29  629 6   HOH   HOH A . 
D 4 HOH   30  630 2   HOH   HOH A . 
D 4 HOH   31  631 22  HOH   HOH A . 
D 4 HOH   32  632 57  HOH   HOH A . 
D 4 HOH   33  633 34  HOH   HOH A . 
D 4 HOH   34  634 46  HOH   HOH A . 
D 4 HOH   35  635 14  HOH   HOH A . 
D 4 HOH   36  636 97  HOH   HOH A . 
D 4 HOH   37  637 8   HOH   HOH A . 
D 4 HOH   38  638 63  HOH   HOH A . 
D 4 HOH   39  639 69  HOH   HOH A . 
D 4 HOH   40  640 9   HOH   HOH A . 
D 4 HOH   41  641 88  HOH   HOH A . 
D 4 HOH   42  642 12  HOH   HOH A . 
D 4 HOH   43  643 20  HOH   HOH A . 
D 4 HOH   44  644 93  HOH   HOH A . 
D 4 HOH   45  645 41  HOH   HOH A . 
D 4 HOH   46  646 108 HOH   HOH A . 
D 4 HOH   47  647 18  HOH   HOH A . 
D 4 HOH   48  648 49  HOH   HOH A . 
D 4 HOH   49  649 43  HOH   HOH A . 
D 4 HOH   50  650 40  HOH   HOH A . 
D 4 HOH   51  651 60  HOH   HOH A . 
D 4 HOH   52  652 28  HOH   HOH A . 
D 4 HOH   53  653 1   HOH   HOH A . 
D 4 HOH   54  654 5   HOH   HOH A . 
D 4 HOH   55  655 74  HOH   HOH A . 
D 4 HOH   56  656 115 HOH   HOH A . 
D 4 HOH   57  657 120 HOH   HOH A . 
D 4 HOH   58  658 26  HOH   HOH A . 
D 4 HOH   59  659 55  HOH   HOH A . 
D 4 HOH   60  660 129 HOH   HOH A . 
D 4 HOH   61  661 149 HOH   HOH A . 
D 4 HOH   62  662 163 HOH   HOH A . 
D 4 HOH   63  663 80  HOH   HOH A . 
D 4 HOH   64  664 124 HOH   HOH A . 
D 4 HOH   65  665 81  HOH   HOH A . 
D 4 HOH   66  666 25  HOH   HOH A . 
D 4 HOH   67  667 112 HOH   HOH A . 
D 4 HOH   68  668 79  HOH   HOH A . 
D 4 HOH   69  669 27  HOH   HOH A . 
D 4 HOH   70  670 87  HOH   HOH A . 
D 4 HOH   71  671 61  HOH   HOH A . 
D 4 HOH   72  672 7   HOH   HOH A . 
D 4 HOH   73  673 48  HOH   HOH A . 
D 4 HOH   74  674 72  HOH   HOH A . 
D 4 HOH   75  675 51  HOH   HOH A . 
D 4 HOH   76  676 24  HOH   HOH A . 
D 4 HOH   77  677 15  HOH   HOH A . 
D 4 HOH   78  678 21  HOH   HOH A . 
D 4 HOH   79  679 16  HOH   HOH A . 
D 4 HOH   80  680 11  HOH   HOH A . 
D 4 HOH   81  681 161 HOH   HOH A . 
D 4 HOH   82  682 82  HOH   HOH A . 
D 4 HOH   83  683 168 HOH   HOH A . 
D 4 HOH   84  684 68  HOH   HOH A . 
D 4 HOH   85  685 75  HOH   HOH A . 
D 4 HOH   86  686 158 HOH   HOH A . 
D 4 HOH   87  687 99  HOH   HOH A . 
D 4 HOH   88  688 3   HOH   HOH A . 
D 4 HOH   89  689 13  HOH   HOH A . 
D 4 HOH   90  690 152 HOH   HOH A . 
D 4 HOH   91  691 52  HOH   HOH A . 
D 4 HOH   92  692 10  HOH   HOH A . 
D 4 HOH   93  693 177 HOH   HOH A . 
D 4 HOH   94  694 53  HOH   HOH A . 
D 4 HOH   95  695 66  HOH   HOH A . 
D 4 HOH   96  696 50  HOH   HOH A . 
D 4 HOH   97  697 64  HOH   HOH A . 
D 4 HOH   98  698 148 HOH   HOH A . 
D 4 HOH   99  699 30  HOH   HOH A . 
D 4 HOH   100 700 106 HOH   HOH A . 
D 4 HOH   101 701 59  HOH   HOH A . 
D 4 HOH   102 702 109 HOH   HOH A . 
D 4 HOH   103 703 132 HOH   HOH A . 
D 4 HOH   104 704 84  HOH   HOH A . 
D 4 HOH   105 705 35  HOH   HOH A . 
D 4 HOH   106 706 45  HOH   HOH A . 
D 4 HOH   107 707 156 HOH   HOH A . 
D 4 HOH   108 708 67  HOH   HOH A . 
D 4 HOH   109 709 37  HOH   HOH A . 
D 4 HOH   110 710 76  HOH   HOH A . 
D 4 HOH   111 711 142 HOH   HOH A . 
D 4 HOH   112 712 94  HOH   HOH A . 
D 4 HOH   113 713 133 HOH   HOH A . 
D 4 HOH   114 714 123 HOH   HOH A . 
D 4 HOH   115 715 56  HOH   HOH A . 
D 4 HOH   116 716 47  HOH   HOH A . 
D 4 HOH   117 717 154 HOH   HOH A . 
D 4 HOH   118 718 157 HOH   HOH A . 
D 4 HOH   119 719 178 HOH   HOH A . 
D 4 HOH   120 720 155 HOH   HOH A . 
D 4 HOH   121 721 105 HOH   HOH A . 
D 4 HOH   122 722 144 HOH   HOH A . 
D 4 HOH   123 723 107 HOH   HOH A . 
D 4 HOH   124 724 184 HOH   HOH A . 
D 4 HOH   125 725 90  HOH   HOH A . 
D 4 HOH   126 726 166 HOH   HOH A . 
D 4 HOH   127 727 146 HOH   HOH A . 
D 4 HOH   128 728 164 HOH   HOH A . 
D 4 HOH   129 729 32  HOH   HOH A . 
D 4 HOH   130 730 181 HOH   HOH A . 
D 4 HOH   131 731 171 HOH   HOH A . 
D 4 HOH   132 732 92  HOH   HOH A . 
D 4 HOH   133 733 147 HOH   HOH A . 
D 4 HOH   134 734 83  HOH   HOH A . 
D 4 HOH   135 735 169 HOH   HOH A . 
D 4 HOH   136 736 139 HOH   HOH A . 
D 4 HOH   137 737 167 HOH   HOH A . 
D 4 HOH   138 738 110 HOH   HOH A . 
D 4 HOH   139 739 172 HOH   HOH A . 
D 4 HOH   140 740 150 HOH   HOH A . 
D 4 HOH   141 741 101 HOH   HOH A . 
D 4 HOH   142 742 118 HOH   HOH A . 
D 4 HOH   143 743 153 HOH   HOH A . 
D 4 HOH   144 744 62  HOH   HOH A . 
D 4 HOH   145 745 134 HOH   HOH A . 
D 4 HOH   146 746 179 HOH   HOH A . 
D 4 HOH   147 747 70  HOH   HOH A . 
D 4 HOH   148 748 116 HOH   HOH A . 
D 4 HOH   149 749 136 HOH   HOH A . 
D 4 HOH   150 750 102 HOH   HOH A . 
D 4 HOH   151 751 183 HOH   HOH A . 
D 4 HOH   152 752 138 HOH   HOH A . 
D 4 HOH   153 753 137 HOH   HOH A . 
D 4 HOH   154 754 122 HOH   HOH A . 
D 4 HOH   155 755 127 HOH   HOH A . 
D 4 HOH   156 756 173 HOH   HOH A . 
D 4 HOH   157 757 117 HOH   HOH A . 
D 4 HOH   158 758 140 HOH   HOH A . 
D 4 HOH   159 759 73  HOH   HOH A . 
D 4 HOH   160 760 71  HOH   HOH A . 
D 4 HOH   161 761 91  HOH   HOH A . 
D 4 HOH   162 762 121 HOH   HOH A . 
D 4 HOH   163 763 145 HOH   HOH A . 
D 4 HOH   164 764 54  HOH   HOH A . 
D 4 HOH   165 765 103 HOH   HOH A . 
D 4 HOH   166 766 38  HOH   HOH A . 
D 4 HOH   167 767 151 HOH   HOH A . 
D 4 HOH   168 768 114 HOH   HOH A . 
D 4 HOH   169 769 128 HOH   HOH A . 
D 4 HOH   170 770 100 HOH   HOH A . 
D 4 HOH   171 771 126 HOH   HOH A . 
D 4 HOH   172 772 180 HOH   HOH A . 
D 4 HOH   173 773 160 HOH   HOH A . 
D 4 HOH   174 774 141 HOH   HOH A . 
D 4 HOH   175 775 98  HOH   HOH A . 
D 4 HOH   176 776 159 HOH   HOH A . 
D 4 HOH   177 777 135 HOH   HOH A . 
D 4 HOH   178 778 174 HOH   HOH A . 
D 4 HOH   179 779 176 HOH   HOH A . 
D 4 HOH   180 780 170 HOH   HOH A . 
D 4 HOH   181 781 175 HOH   HOH A . 
E 4 HOH   1   201 89  HOH   HOH B . 
E 4 HOH   2   202 131 HOH   HOH B . 
E 4 HOH   3   203 86  HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX    ? ? ? 1.20.1_4487 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? pointless ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS       ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX    ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.830 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YWU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.180 
_cell.length_a_esd                 ? 
_cell.length_b                     61.876 
_cell.length_b_esd                 ? 
_cell.length_c                     53.718 
_cell.length_c_esd                 ? 
_cell.volume                       144476.548 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YWU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YWU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.18 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.66 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES-NaOH, 19-23% PEG 4000, 19-23% 1,2-propanediol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-02-03 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL45XU' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL45XU 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          32.71 
_reflns.entry_id                                       8YWU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.77 
_reflns.d_resolution_low                               43.47 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     53969 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.86 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.120 
_reflns.pdbx_Rpim_I_all                                0.066 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.993 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.100 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.77 
_reflns_shell.d_res_low                                     1.83 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5482 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.886 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.386 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.391 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               34.52 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YWU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.77 
_refine.ls_d_res_low                             43.47 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     27724 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  25724 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.74 
_refine.ls_percent_reflns_R_free                 7.21 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1914 
_refine.ls_R_factor_R_free                       0.2295 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1884 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.3047 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3018 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.77 
_refine_hist.d_res_low                        43.47 
_refine_hist.number_atoms_solvent             184 
_refine_hist.number_atoms_total               2312 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2088 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         40 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0075  ? 2175 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9500  ? 2932 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0512  ? 335  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0075  ? 365  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 20.2826 ? 304  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.77 1.82  . . 139 1794 97.97  . . . . 0.4316 . . . . . . . . . . . 0.4892 
'X-RAY DIFFRACTION' 1.82 1.86  . . 142 1822 99.95  . . . . 0.3667 . . . . . . . . . . . 0.4214 
'X-RAY DIFFRACTION' 1.86 1.92  . . 142 1826 99.95  . . . . 0.3075 . . . . . . . . . . . 0.3576 
'X-RAY DIFFRACTION' 1.92 1.98  . . 143 1826 100.00 . . . . 0.2632 . . . . . . . . . . . 0.3241 
'X-RAY DIFFRACTION' 1.98 2.05  . . 144 1864 99.85  . . . . 0.2262 . . . . . . . . . . . 0.2821 
'X-RAY DIFFRACTION' 2.05 2.13  . . 142 1822 99.90  . . . . 0.2166 . . . . . . . . . . . 0.2673 
'X-RAY DIFFRACTION' 2.13 2.23  . . 141 1814 99.95  . . . . 0.2238 . . . . . . . . . . . 0.2803 
'X-RAY DIFFRACTION' 2.23 2.35  . . 144 1843 99.95  . . . . 0.2044 . . . . . . . . . . . 0.2589 
'X-RAY DIFFRACTION' 2.35 2.50  . . 143 1847 100.00 . . . . 0.1864 . . . . . . . . . . . 0.2723 
'X-RAY DIFFRACTION' 2.50 2.69  . . 143 1844 99.90  . . . . 0.1968 . . . . . . . . . . . 0.2525 
'X-RAY DIFFRACTION' 2.69 2.96  . . 143 1837 99.85  . . . . 0.1941 . . . . . . . . . . . 0.2521 
'X-RAY DIFFRACTION' 2.96 3.39  . . 143 1839 99.90  . . . . 0.1848 . . . . . . . . . . . 0.2180 
'X-RAY DIFFRACTION' 3.39 4.27  . . 143 1848 99.35  . . . . 0.1502 . . . . . . . . . . . 0.1945 
'X-RAY DIFFRACTION' 4.27 43.47 . . 148 1898 99.80  . . . . 0.1531 . . . . . . . . . . . 0.1630 
# 
_struct.entry_id                     8YWU 
_struct.title                        
'Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YWU 
_struct_keywords.text            'Agonist, Complex, Nuclear receptor, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PPARA_HUMAN Q07869 ? 1 
;TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT
SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE
HAQLVQIIKKTESDAALHPLLQEIYRDMY
;
200 
2 UNP PRGC1_HUMAN Q9UBK2 ? 2 PQEAEEPSLLKKLLLAPANTQL 135 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YWU A 4 ? 272 ? Q07869 200 ? 468 ? 200 468 
2 2 8YWU B 1 ? 22  ? Q9UBK2 135 ? 156 ? 135 156 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YWU GLY A 1 ? UNP Q07869 ? ? 'expression tag' 197 1 
1 8YWU GLY A 2 ? UNP Q07869 ? ? 'expression tag' 198 2 
1 8YWU GLN A 3 ? UNP Q07869 ? ? 'expression tag' 199 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1070  ? 
1 MORE         -10   ? 
1 'SSA (A^2)'  12430 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? PHE A 22  ? SER A 205 PHE A 218 1 ? 14 
HELX_P HELX_P2  AA2 ASN A 25  ? LEU A 33  ? ASN A 221 LEU A 229 1 ? 9  
HELX_P HELX_P3  AA3 ASP A 47  ? VAL A 59  ? ASP A 243 VAL A 255 1 ? 13 
HELX_P HELX_P4  AA4 GLU A 71  ? ALA A 97  ? GLU A 267 ALA A 293 1 ? 27 
HELX_P HELX_P5  AA5 GLY A 100 ? LEU A 104 ? GLY A 296 LEU A 300 5 ? 5  
HELX_P HELX_P6  AA6 ASP A 105 ? SER A 126 ? ASP A 301 SER A 322 1 ? 22 
HELX_P HELX_P7  AA7 SER A 127 ? MET A 129 ? SER A 323 MET A 325 5 ? 3  
HELX_P HELX_P8  AA8 ARG A 145 ? SER A 150 ? ARG A 341 SER A 346 1 ? 6  
HELX_P HELX_P9  AA9 PRO A 154 ? ILE A 158 ? PRO A 350 ILE A 354 5 ? 5  
HELX_P HELX_P10 AB1 MET A 159 ? ALA A 171 ? MET A 355 ALA A 367 1 ? 13 
HELX_P HELX_P11 AB2 ASP A 175 ? CYS A 188 ? ASP A 371 CYS A 384 1 ? 14 
HELX_P HELX_P12 AB3 ASN A 197 ? HIS A 220 ? ASN A 393 HIS A 416 1 ? 24 
HELX_P HELX_P13 AB4 PHE A 225 ? GLU A 255 ? PHE A 421 GLU A 451 1 ? 31 
HELX_P HELX_P14 AB5 HIS A 261 ? ARG A 269 ? HIS A 457 ARG A 465 1 ? 9  
HELX_P HELX_P15 AB6 SER B 8   ? LEU B 15  ? SER B 142 LEU B 149 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LYS 
_struct_mon_prot_cis.label_seq_id           153 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LYS 
_struct_mon_prot_cis.auth_seq_id            349 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    154 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     350 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       2.61 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   3 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 43  ? ILE A 45  ? PHE A 239 ILE A 241 
AA1 2 GLY A 141 ? THR A 144 ? GLY A 337 THR A 340 
AA1 3 GLY A 133 ? VAL A 136 ? GLY A 329 VAL A 332 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 45  ? N ILE A 241 O PHE A 142 ? O PHE A 338 
AA1 2 3 O GLY A 141 ? O GLY A 337 N VAL A 136 ? N VAL A 332 
# 
_pdbx_entry_details.entry_id                   8YWU 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 393 ? ? -107.87 72.19 
2 1 ALA A 454 ? ? -104.41 78.74 
3 1 LEU B 149 ? ? -100.71 72.69 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 779 ? 5.85 . 
2 1 O ? A HOH 780 ? 5.99 . 
3 1 O ? A HOH 781 ? 6.14 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 197 ? A GLY 1  
2  1 Y 1 A GLY 198 ? A GLY 2  
3  1 Y 1 A GLN 199 ? A GLN 3  
4  1 Y 1 A THR 200 ? A THR 4  
5  1 Y 1 A ALA 201 ? A ALA 5  
6  1 Y 1 A ASP 202 ? A ASP 6  
7  1 Y 1 A LEU 203 ? A LEU 7  
8  1 Y 1 A LYS 204 ? A LYS 8  
9  1 Y 1 A GLY 231 ? A GLY 35 
10 1 Y 1 A LYS 232 ? A LYS 36 
11 1 Y 1 A ALA 233 ? A ALA 37 
12 1 Y 1 A SER 234 ? A SER 38 
13 1 Y 1 A ASN 235 ? A ASN 39 
14 1 Y 1 A ASN 236 ? A ASN 40 
15 1 Y 1 A VAL 259 ? A VAL 63 
16 1 Y 1 A ALA 260 ? A ALA 64 
17 1 Y 1 A ASN 261 ? A ASN 65 
18 1 Y 1 A GLY 262 ? A GLY 66 
19 1 Y 1 A ILE 263 ? A ILE 67 
20 1 Y 1 A GLN 264 ? A GLN 68 
21 1 Y 1 B PRO 135 ? B PRO 1  
22 1 Y 1 B GLN 136 ? B GLN 2  
23 1 Y 1 B GLU 137 ? B GLU 3  
24 1 Y 1 B ALA 138 ? B ALA 4  
25 1 Y 1 B GLU 139 ? B GLU 5  
26 1 Y 1 B GLU 140 ? B GLU 6  
27 1 Y 1 B PRO 151 ? B PRO 17 
28 1 Y 1 B ALA 152 ? B ALA 18 
29 1 Y 1 B ASN 153 ? B ASN 19 
30 1 Y 1 B THR 154 ? B THR 20 
31 1 Y 1 B GLN 155 ? B GLN 21 
32 1 Y 1 B LEU 156 ? B LEU 22 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1LZ9 C01  C Y N 1   
A1LZ9 C02  C Y N 2   
A1LZ9 C03  C Y N 3   
A1LZ9 C04  C Y N 4   
A1LZ9 C05  C Y N 5   
A1LZ9 C06  C Y N 6   
A1LZ9 C07  C N N 7   
A1LZ9 C08  C N N 8   
A1LZ9 C09  C N N 9   
A1LZ9 C10  C N N 10  
A1LZ9 C11  C N N 11  
A1LZ9 C12  C N N 12  
A1LZ9 C13  C N N 13  
A1LZ9 C14  C Y N 14  
A1LZ9 C15  C Y N 15  
A1LZ9 C16  C Y N 16  
A1LZ9 C17  C Y N 17  
A1LZ9 C18  C Y N 18  
A1LZ9 C19  C Y N 19  
A1LZ9 C26  C N N 20  
A1LZ9 C28  C N N 21  
A1LZ9 C29  C Y N 22  
A1LZ9 C30  C Y N 23  
A1LZ9 C32  C Y N 24  
A1LZ9 C34  C Y N 25  
A1LZ9 C35  C Y N 26  
A1LZ9 C36  C Y N 27  
A1LZ9 C37  C Y N 28  
A1LZ9 C38  C Y N 29  
A1LZ9 C39  C Y N 30  
A1LZ9 C40  C N N 31  
A1LZ9 F20  F N N 32  
A1LZ9 N21  N Y N 33  
A1LZ9 N22  N Y N 34  
A1LZ9 N23  N Y N 35  
A1LZ9 N33  N Y N 36  
A1LZ9 O24  O N N 37  
A1LZ9 O25  O N N 38  
A1LZ9 O27  O N N 39  
A1LZ9 O31  O Y N 40  
A1LZ9 H1   H N N 41  
A1LZ9 H2   H N N 42  
A1LZ9 H3   H N N 43  
A1LZ9 H4   H N N 44  
A1LZ9 H5   H N N 45  
A1LZ9 H6   H N N 46  
A1LZ9 H7   H N N 47  
A1LZ9 H8   H N N 48  
A1LZ9 H9   H N N 49  
A1LZ9 H10  H N N 50  
A1LZ9 H11  H N N 51  
A1LZ9 H12  H N N 52  
A1LZ9 H13  H N N 53  
A1LZ9 H14  H N N 54  
A1LZ9 H15  H N N 55  
A1LZ9 H16  H N N 56  
A1LZ9 H17  H N N 57  
A1LZ9 H18  H N N 58  
A1LZ9 H19  H N N 59  
A1LZ9 H20  H N N 60  
A1LZ9 H21  H N N 61  
A1LZ9 H22  H N N 62  
A1LZ9 H23  H N N 63  
A1LZ9 H24  H N N 64  
A1LZ9 H25  H N N 65  
A1LZ9 H26  H N N 66  
A1LZ9 H27  H N N 67  
A1LZ9 H28  H N N 68  
A1LZ9 H29  H N N 69  
A1LZ9 H30  H N N 70  
A1LZ9 H31  H N N 71  
ALA   N    N N N 72  
ALA   CA   C N S 73  
ALA   C    C N N 74  
ALA   O    O N N 75  
ALA   CB   C N N 76  
ALA   OXT  O N N 77  
ALA   H    H N N 78  
ALA   H2   H N N 79  
ALA   HA   H N N 80  
ALA   HB1  H N N 81  
ALA   HB2  H N N 82  
ALA   HB3  H N N 83  
ALA   HXT  H N N 84  
ARG   N    N N N 85  
ARG   CA   C N S 86  
ARG   C    C N N 87  
ARG   O    O N N 88  
ARG   CB   C N N 89  
ARG   CG   C N N 90  
ARG   CD   C N N 91  
ARG   NE   N N N 92  
ARG   CZ   C N N 93  
ARG   NH1  N N N 94  
ARG   NH2  N N N 95  
ARG   OXT  O N N 96  
ARG   H    H N N 97  
ARG   H2   H N N 98  
ARG   HA   H N N 99  
ARG   HB2  H N N 100 
ARG   HB3  H N N 101 
ARG   HG2  H N N 102 
ARG   HG3  H N N 103 
ARG   HD2  H N N 104 
ARG   HD3  H N N 105 
ARG   HE   H N N 106 
ARG   HH11 H N N 107 
ARG   HH12 H N N 108 
ARG   HH21 H N N 109 
ARG   HH22 H N N 110 
ARG   HXT  H N N 111 
ASN   N    N N N 112 
ASN   CA   C N S 113 
ASN   C    C N N 114 
ASN   O    O N N 115 
ASN   CB   C N N 116 
ASN   CG   C N N 117 
ASN   OD1  O N N 118 
ASN   ND2  N N N 119 
ASN   OXT  O N N 120 
ASN   H    H N N 121 
ASN   H2   H N N 122 
ASN   HA   H N N 123 
ASN   HB2  H N N 124 
ASN   HB3  H N N 125 
ASN   HD21 H N N 126 
ASN   HD22 H N N 127 
ASN   HXT  H N N 128 
ASP   N    N N N 129 
ASP   CA   C N S 130 
ASP   C    C N N 131 
ASP   O    O N N 132 
ASP   CB   C N N 133 
ASP   CG   C N N 134 
ASP   OD1  O N N 135 
ASP   OD2  O N N 136 
ASP   OXT  O N N 137 
ASP   H    H N N 138 
ASP   H2   H N N 139 
ASP   HA   H N N 140 
ASP   HB2  H N N 141 
ASP   HB3  H N N 142 
ASP   HD2  H N N 143 
ASP   HXT  H N N 144 
CYS   N    N N N 145 
CYS   CA   C N R 146 
CYS   C    C N N 147 
CYS   O    O N N 148 
CYS   CB   C N N 149 
CYS   SG   S N N 150 
CYS   OXT  O N N 151 
CYS   H    H N N 152 
CYS   H2   H N N 153 
CYS   HA   H N N 154 
CYS   HB2  H N N 155 
CYS   HB3  H N N 156 
CYS   HG   H N N 157 
CYS   HXT  H N N 158 
GLN   N    N N N 159 
GLN   CA   C N S 160 
GLN   C    C N N 161 
GLN   O    O N N 162 
GLN   CB   C N N 163 
GLN   CG   C N N 164 
GLN   CD   C N N 165 
GLN   OE1  O N N 166 
GLN   NE2  N N N 167 
GLN   OXT  O N N 168 
GLN   H    H N N 169 
GLN   H2   H N N 170 
GLN   HA   H N N 171 
GLN   HB2  H N N 172 
GLN   HB3  H N N 173 
GLN   HG2  H N N 174 
GLN   HG3  H N N 175 
GLN   HE21 H N N 176 
GLN   HE22 H N N 177 
GLN   HXT  H N N 178 
GLU   N    N N N 179 
GLU   CA   C N S 180 
GLU   C    C N N 181 
GLU   O    O N N 182 
GLU   CB   C N N 183 
GLU   CG   C N N 184 
GLU   CD   C N N 185 
GLU   OE1  O N N 186 
GLU   OE2  O N N 187 
GLU   OXT  O N N 188 
GLU   H    H N N 189 
GLU   H2   H N N 190 
GLU   HA   H N N 191 
GLU   HB2  H N N 192 
GLU   HB3  H N N 193 
GLU   HG2  H N N 194 
GLU   HG3  H N N 195 
GLU   HE2  H N N 196 
GLU   HXT  H N N 197 
GLY   N    N N N 198 
GLY   CA   C N N 199 
GLY   C    C N N 200 
GLY   O    O N N 201 
GLY   OXT  O N N 202 
GLY   H    H N N 203 
GLY   H2   H N N 204 
GLY   HA2  H N N 205 
GLY   HA3  H N N 206 
GLY   HXT  H N N 207 
HIS   N    N N N 208 
HIS   CA   C N S 209 
HIS   C    C N N 210 
HIS   O    O N N 211 
HIS   CB   C N N 212 
HIS   CG   C Y N 213 
HIS   ND1  N Y N 214 
HIS   CD2  C Y N 215 
HIS   CE1  C Y N 216 
HIS   NE2  N Y N 217 
HIS   OXT  O N N 218 
HIS   H    H N N 219 
HIS   H2   H N N 220 
HIS   HA   H N N 221 
HIS   HB2  H N N 222 
HIS   HB3  H N N 223 
HIS   HD1  H N N 224 
HIS   HD2  H N N 225 
HIS   HE1  H N N 226 
HIS   HE2  H N N 227 
HIS   HXT  H N N 228 
HOH   O    O N N 229 
HOH   H1   H N N 230 
HOH   H2   H N N 231 
ILE   N    N N N 232 
ILE   CA   C N S 233 
ILE   C    C N N 234 
ILE   O    O N N 235 
ILE   CB   C N S 236 
ILE   CG1  C N N 237 
ILE   CG2  C N N 238 
ILE   CD1  C N N 239 
ILE   OXT  O N N 240 
ILE   H    H N N 241 
ILE   H2   H N N 242 
ILE   HA   H N N 243 
ILE   HB   H N N 244 
ILE   HG12 H N N 245 
ILE   HG13 H N N 246 
ILE   HG21 H N N 247 
ILE   HG22 H N N 248 
ILE   HG23 H N N 249 
ILE   HD11 H N N 250 
ILE   HD12 H N N 251 
ILE   HD13 H N N 252 
ILE   HXT  H N N 253 
LEU   N    N N N 254 
LEU   CA   C N S 255 
LEU   C    C N N 256 
LEU   O    O N N 257 
LEU   CB   C N N 258 
LEU   CG   C N N 259 
LEU   CD1  C N N 260 
LEU   CD2  C N N 261 
LEU   OXT  O N N 262 
LEU   H    H N N 263 
LEU   H2   H N N 264 
LEU   HA   H N N 265 
LEU   HB2  H N N 266 
LEU   HB3  H N N 267 
LEU   HG   H N N 268 
LEU   HD11 H N N 269 
LEU   HD12 H N N 270 
LEU   HD13 H N N 271 
LEU   HD21 H N N 272 
LEU   HD22 H N N 273 
LEU   HD23 H N N 274 
LEU   HXT  H N N 275 
LYS   N    N N N 276 
LYS   CA   C N S 277 
LYS   C    C N N 278 
LYS   O    O N N 279 
LYS   CB   C N N 280 
LYS   CG   C N N 281 
LYS   CD   C N N 282 
LYS   CE   C N N 283 
LYS   NZ   N N N 284 
LYS   OXT  O N N 285 
LYS   H    H N N 286 
LYS   H2   H N N 287 
LYS   HA   H N N 288 
LYS   HB2  H N N 289 
LYS   HB3  H N N 290 
LYS   HG2  H N N 291 
LYS   HG3  H N N 292 
LYS   HD2  H N N 293 
LYS   HD3  H N N 294 
LYS   HE2  H N N 295 
LYS   HE3  H N N 296 
LYS   HZ1  H N N 297 
LYS   HZ2  H N N 298 
LYS   HZ3  H N N 299 
LYS   HXT  H N N 300 
MET   N    N N N 301 
MET   CA   C N S 302 
MET   C    C N N 303 
MET   O    O N N 304 
MET   CB   C N N 305 
MET   CG   C N N 306 
MET   SD   S N N 307 
MET   CE   C N N 308 
MET   OXT  O N N 309 
MET   H    H N N 310 
MET   H2   H N N 311 
MET   HA   H N N 312 
MET   HB2  H N N 313 
MET   HB3  H N N 314 
MET   HG2  H N N 315 
MET   HG3  H N N 316 
MET   HE1  H N N 317 
MET   HE2  H N N 318 
MET   HE3  H N N 319 
MET   HXT  H N N 320 
PHE   N    N N N 321 
PHE   CA   C N S 322 
PHE   C    C N N 323 
PHE   O    O N N 324 
PHE   CB   C N N 325 
PHE   CG   C Y N 326 
PHE   CD1  C Y N 327 
PHE   CD2  C Y N 328 
PHE   CE1  C Y N 329 
PHE   CE2  C Y N 330 
PHE   CZ   C Y N 331 
PHE   OXT  O N N 332 
PHE   H    H N N 333 
PHE   H2   H N N 334 
PHE   HA   H N N 335 
PHE   HB2  H N N 336 
PHE   HB3  H N N 337 
PHE   HD1  H N N 338 
PHE   HD2  H N N 339 
PHE   HE1  H N N 340 
PHE   HE2  H N N 341 
PHE   HZ   H N N 342 
PHE   HXT  H N N 343 
PRO   N    N N N 344 
PRO   CA   C N S 345 
PRO   C    C N N 346 
PRO   O    O N N 347 
PRO   CB   C N N 348 
PRO   CG   C N N 349 
PRO   CD   C N N 350 
PRO   OXT  O N N 351 
PRO   H    H N N 352 
PRO   HA   H N N 353 
PRO   HB2  H N N 354 
PRO   HB3  H N N 355 
PRO   HG2  H N N 356 
PRO   HG3  H N N 357 
PRO   HD2  H N N 358 
PRO   HD3  H N N 359 
PRO   HXT  H N N 360 
SER   N    N N N 361 
SER   CA   C N S 362 
SER   C    C N N 363 
SER   O    O N N 364 
SER   CB   C N N 365 
SER   OG   O N N 366 
SER   OXT  O N N 367 
SER   H    H N N 368 
SER   H2   H N N 369 
SER   HA   H N N 370 
SER   HB2  H N N 371 
SER   HB3  H N N 372 
SER   HG   H N N 373 
SER   HXT  H N N 374 
THR   N    N N N 375 
THR   CA   C N S 376 
THR   C    C N N 377 
THR   O    O N N 378 
THR   CB   C N R 379 
THR   OG1  O N N 380 
THR   CG2  C N N 381 
THR   OXT  O N N 382 
THR   H    H N N 383 
THR   H2   H N N 384 
THR   HA   H N N 385 
THR   HB   H N N 386 
THR   HG1  H N N 387 
THR   HG21 H N N 388 
THR   HG22 H N N 389 
THR   HG23 H N N 390 
THR   HXT  H N N 391 
TYR   N    N N N 392 
TYR   CA   C N S 393 
TYR   C    C N N 394 
TYR   O    O N N 395 
TYR   CB   C N N 396 
TYR   CG   C Y N 397 
TYR   CD1  C Y N 398 
TYR   CD2  C Y N 399 
TYR   CE1  C Y N 400 
TYR   CE2  C Y N 401 
TYR   CZ   C Y N 402 
TYR   OH   O N N 403 
TYR   OXT  O N N 404 
TYR   H    H N N 405 
TYR   H2   H N N 406 
TYR   HA   H N N 407 
TYR   HB2  H N N 408 
TYR   HB3  H N N 409 
TYR   HD1  H N N 410 
TYR   HD2  H N N 411 
TYR   HE1  H N N 412 
TYR   HE2  H N N 413 
TYR   HH   H N N 414 
TYR   HXT  H N N 415 
VAL   N    N N N 416 
VAL   CA   C N S 417 
VAL   C    C N N 418 
VAL   O    O N N 419 
VAL   CB   C N N 420 
VAL   CG1  C N N 421 
VAL   CG2  C N N 422 
VAL   OXT  O N N 423 
VAL   H    H N N 424 
VAL   H2   H N N 425 
VAL   HA   H N N 426 
VAL   HB   H N N 427 
VAL   HG11 H N N 428 
VAL   HG12 H N N 429 
VAL   HG13 H N N 430 
VAL   HG21 H N N 431 
VAL   HG22 H N N 432 
VAL   HG23 H N N 433 
VAL   HXT  H N N 434 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1LZ9 C01 C02  doub Y N 1   
A1LZ9 C01 C07  sing N N 2   
A1LZ9 C01 N21  sing Y N 3   
A1LZ9 C02 C03  sing Y N 4   
A1LZ9 C03 C04  doub Y N 5   
A1LZ9 C03 C08  sing N N 6   
A1LZ9 C04 C05  sing Y N 7   
A1LZ9 C04 C06  sing Y N 8   
A1LZ9 C05 N21  doub Y N 9   
A1LZ9 C05 N23  sing Y N 10  
A1LZ9 C06 C09  sing N N 11  
A1LZ9 C06 N22  doub Y N 12  
A1LZ9 C08 O24  doub N N 13  
A1LZ9 C08 O25  sing N N 14  
A1LZ9 C09 C10  sing N N 15  
A1LZ9 C09 C11  sing N N 16  
A1LZ9 C10 C12  sing N N 17  
A1LZ9 C11 C13  sing N N 18  
A1LZ9 C14 C15  doub Y N 19  
A1LZ9 C14 C19  sing Y N 20  
A1LZ9 C15 C16  sing Y N 21  
A1LZ9 C16 C17  doub Y N 22  
A1LZ9 C16 F20  sing N N 23  
A1LZ9 C17 C18  sing Y N 24  
A1LZ9 C18 C19  doub Y N 25  
A1LZ9 C19 N23  sing N N 26  
A1LZ9 N22 N23  sing Y N 27  
A1LZ9 C26 O27  sing N N 28  
A1LZ9 C28 C29  sing N N 29  
A1LZ9 C30 O31  sing Y N 30  
A1LZ9 O31 C32  sing Y N 31  
A1LZ9 C32 N33  doub Y N 32  
A1LZ9 C29 C30  doub Y N 33  
A1LZ9 C29 N33  sing Y N 34  
A1LZ9 C32 C34  sing N N 35  
A1LZ9 C35 C36  doub Y N 36  
A1LZ9 C36 C37  sing Y N 37  
A1LZ9 C37 C38  doub Y N 38  
A1LZ9 C38 C39  sing Y N 39  
A1LZ9 C34 C35  sing Y N 40  
A1LZ9 C34 C39  doub Y N 41  
A1LZ9 C30 C40  sing N N 42  
A1LZ9 C07 C26  sing N N 43  
A1LZ9 O27 C28  sing N N 44  
A1LZ9 C02 H1   sing N N 45  
A1LZ9 C07 H2   sing N N 46  
A1LZ9 C07 H3   sing N N 47  
A1LZ9 C09 H4   sing N N 48  
A1LZ9 C10 H5   sing N N 49  
A1LZ9 C10 H6   sing N N 50  
A1LZ9 C11 H7   sing N N 51  
A1LZ9 C11 H8   sing N N 52  
A1LZ9 C12 H9   sing N N 53  
A1LZ9 C12 H10  sing N N 54  
A1LZ9 C12 H11  sing N N 55  
A1LZ9 C13 H12  sing N N 56  
A1LZ9 C13 H13  sing N N 57  
A1LZ9 C13 H14  sing N N 58  
A1LZ9 C14 H15  sing N N 59  
A1LZ9 C15 H16  sing N N 60  
A1LZ9 C17 H17  sing N N 61  
A1LZ9 C18 H18  sing N N 62  
A1LZ9 C26 H19  sing N N 63  
A1LZ9 C26 H20  sing N N 64  
A1LZ9 C28 H21  sing N N 65  
A1LZ9 C28 H22  sing N N 66  
A1LZ9 C35 H23  sing N N 67  
A1LZ9 C36 H24  sing N N 68  
A1LZ9 C37 H25  sing N N 69  
A1LZ9 C38 H26  sing N N 70  
A1LZ9 C39 H27  sing N N 71  
A1LZ9 C40 H28  sing N N 72  
A1LZ9 C40 H29  sing N N 73  
A1LZ9 C40 H30  sing N N 74  
A1LZ9 O25 H31  sing N N 75  
ALA   N   CA   sing N N 76  
ALA   N   H    sing N N 77  
ALA   N   H2   sing N N 78  
ALA   CA  C    sing N N 79  
ALA   CA  CB   sing N N 80  
ALA   CA  HA   sing N N 81  
ALA   C   O    doub N N 82  
ALA   C   OXT  sing N N 83  
ALA   CB  HB1  sing N N 84  
ALA   CB  HB2  sing N N 85  
ALA   CB  HB3  sing N N 86  
ALA   OXT HXT  sing N N 87  
ARG   N   CA   sing N N 88  
ARG   N   H    sing N N 89  
ARG   N   H2   sing N N 90  
ARG   CA  C    sing N N 91  
ARG   CA  CB   sing N N 92  
ARG   CA  HA   sing N N 93  
ARG   C   O    doub N N 94  
ARG   C   OXT  sing N N 95  
ARG   CB  CG   sing N N 96  
ARG   CB  HB2  sing N N 97  
ARG   CB  HB3  sing N N 98  
ARG   CG  CD   sing N N 99  
ARG   CG  HG2  sing N N 100 
ARG   CG  HG3  sing N N 101 
ARG   CD  NE   sing N N 102 
ARG   CD  HD2  sing N N 103 
ARG   CD  HD3  sing N N 104 
ARG   NE  CZ   sing N N 105 
ARG   NE  HE   sing N N 106 
ARG   CZ  NH1  sing N N 107 
ARG   CZ  NH2  doub N N 108 
ARG   NH1 HH11 sing N N 109 
ARG   NH1 HH12 sing N N 110 
ARG   NH2 HH21 sing N N 111 
ARG   NH2 HH22 sing N N 112 
ARG   OXT HXT  sing N N 113 
ASN   N   CA   sing N N 114 
ASN   N   H    sing N N 115 
ASN   N   H2   sing N N 116 
ASN   CA  C    sing N N 117 
ASN   CA  CB   sing N N 118 
ASN   CA  HA   sing N N 119 
ASN   C   O    doub N N 120 
ASN   C   OXT  sing N N 121 
ASN   CB  CG   sing N N 122 
ASN   CB  HB2  sing N N 123 
ASN   CB  HB3  sing N N 124 
ASN   CG  OD1  doub N N 125 
ASN   CG  ND2  sing N N 126 
ASN   ND2 HD21 sing N N 127 
ASN   ND2 HD22 sing N N 128 
ASN   OXT HXT  sing N N 129 
ASP   N   CA   sing N N 130 
ASP   N   H    sing N N 131 
ASP   N   H2   sing N N 132 
ASP   CA  C    sing N N 133 
ASP   CA  CB   sing N N 134 
ASP   CA  HA   sing N N 135 
ASP   C   O    doub N N 136 
ASP   C   OXT  sing N N 137 
ASP   CB  CG   sing N N 138 
ASP   CB  HB2  sing N N 139 
ASP   CB  HB3  sing N N 140 
ASP   CG  OD1  doub N N 141 
ASP   CG  OD2  sing N N 142 
ASP   OD2 HD2  sing N N 143 
ASP   OXT HXT  sing N N 144 
CYS   N   CA   sing N N 145 
CYS   N   H    sing N N 146 
CYS   N   H2   sing N N 147 
CYS   CA  C    sing N N 148 
CYS   CA  CB   sing N N 149 
CYS   CA  HA   sing N N 150 
CYS   C   O    doub N N 151 
CYS   C   OXT  sing N N 152 
CYS   CB  SG   sing N N 153 
CYS   CB  HB2  sing N N 154 
CYS   CB  HB3  sing N N 155 
CYS   SG  HG   sing N N 156 
CYS   OXT HXT  sing N N 157 
GLN   N   CA   sing N N 158 
GLN   N   H    sing N N 159 
GLN   N   H2   sing N N 160 
GLN   CA  C    sing N N 161 
GLN   CA  CB   sing N N 162 
GLN   CA  HA   sing N N 163 
GLN   C   O    doub N N 164 
GLN   C   OXT  sing N N 165 
GLN   CB  CG   sing N N 166 
GLN   CB  HB2  sing N N 167 
GLN   CB  HB3  sing N N 168 
GLN   CG  CD   sing N N 169 
GLN   CG  HG2  sing N N 170 
GLN   CG  HG3  sing N N 171 
GLN   CD  OE1  doub N N 172 
GLN   CD  NE2  sing N N 173 
GLN   NE2 HE21 sing N N 174 
GLN   NE2 HE22 sing N N 175 
GLN   OXT HXT  sing N N 176 
GLU   N   CA   sing N N 177 
GLU   N   H    sing N N 178 
GLU   N   H2   sing N N 179 
GLU   CA  C    sing N N 180 
GLU   CA  CB   sing N N 181 
GLU   CA  HA   sing N N 182 
GLU   C   O    doub N N 183 
GLU   C   OXT  sing N N 184 
GLU   CB  CG   sing N N 185 
GLU   CB  HB2  sing N N 186 
GLU   CB  HB3  sing N N 187 
GLU   CG  CD   sing N N 188 
GLU   CG  HG2  sing N N 189 
GLU   CG  HG3  sing N N 190 
GLU   CD  OE1  doub N N 191 
GLU   CD  OE2  sing N N 192 
GLU   OE2 HE2  sing N N 193 
GLU   OXT HXT  sing N N 194 
GLY   N   CA   sing N N 195 
GLY   N   H    sing N N 196 
GLY   N   H2   sing N N 197 
GLY   CA  C    sing N N 198 
GLY   CA  HA2  sing N N 199 
GLY   CA  HA3  sing N N 200 
GLY   C   O    doub N N 201 
GLY   C   OXT  sing N N 202 
GLY   OXT HXT  sing N N 203 
HIS   N   CA   sing N N 204 
HIS   N   H    sing N N 205 
HIS   N   H2   sing N N 206 
HIS   CA  C    sing N N 207 
HIS   CA  CB   sing N N 208 
HIS   CA  HA   sing N N 209 
HIS   C   O    doub N N 210 
HIS   C   OXT  sing N N 211 
HIS   CB  CG   sing N N 212 
HIS   CB  HB2  sing N N 213 
HIS   CB  HB3  sing N N 214 
HIS   CG  ND1  sing Y N 215 
HIS   CG  CD2  doub Y N 216 
HIS   ND1 CE1  doub Y N 217 
HIS   ND1 HD1  sing N N 218 
HIS   CD2 NE2  sing Y N 219 
HIS   CD2 HD2  sing N N 220 
HIS   CE1 NE2  sing Y N 221 
HIS   CE1 HE1  sing N N 222 
HIS   NE2 HE2  sing N N 223 
HIS   OXT HXT  sing N N 224 
HOH   O   H1   sing N N 225 
HOH   O   H2   sing N N 226 
ILE   N   CA   sing N N 227 
ILE   N   H    sing N N 228 
ILE   N   H2   sing N N 229 
ILE   CA  C    sing N N 230 
ILE   CA  CB   sing N N 231 
ILE   CA  HA   sing N N 232 
ILE   C   O    doub N N 233 
ILE   C   OXT  sing N N 234 
ILE   CB  CG1  sing N N 235 
ILE   CB  CG2  sing N N 236 
ILE   CB  HB   sing N N 237 
ILE   CG1 CD1  sing N N 238 
ILE   CG1 HG12 sing N N 239 
ILE   CG1 HG13 sing N N 240 
ILE   CG2 HG21 sing N N 241 
ILE   CG2 HG22 sing N N 242 
ILE   CG2 HG23 sing N N 243 
ILE   CD1 HD11 sing N N 244 
ILE   CD1 HD12 sing N N 245 
ILE   CD1 HD13 sing N N 246 
ILE   OXT HXT  sing N N 247 
LEU   N   CA   sing N N 248 
LEU   N   H    sing N N 249 
LEU   N   H2   sing N N 250 
LEU   CA  C    sing N N 251 
LEU   CA  CB   sing N N 252 
LEU   CA  HA   sing N N 253 
LEU   C   O    doub N N 254 
LEU   C   OXT  sing N N 255 
LEU   CB  CG   sing N N 256 
LEU   CB  HB2  sing N N 257 
LEU   CB  HB3  sing N N 258 
LEU   CG  CD1  sing N N 259 
LEU   CG  CD2  sing N N 260 
LEU   CG  HG   sing N N 261 
LEU   CD1 HD11 sing N N 262 
LEU   CD1 HD12 sing N N 263 
LEU   CD1 HD13 sing N N 264 
LEU   CD2 HD21 sing N N 265 
LEU   CD2 HD22 sing N N 266 
LEU   CD2 HD23 sing N N 267 
LEU   OXT HXT  sing N N 268 
LYS   N   CA   sing N N 269 
LYS   N   H    sing N N 270 
LYS   N   H2   sing N N 271 
LYS   CA  C    sing N N 272 
LYS   CA  CB   sing N N 273 
LYS   CA  HA   sing N N 274 
LYS   C   O    doub N N 275 
LYS   C   OXT  sing N N 276 
LYS   CB  CG   sing N N 277 
LYS   CB  HB2  sing N N 278 
LYS   CB  HB3  sing N N 279 
LYS   CG  CD   sing N N 280 
LYS   CG  HG2  sing N N 281 
LYS   CG  HG3  sing N N 282 
LYS   CD  CE   sing N N 283 
LYS   CD  HD2  sing N N 284 
LYS   CD  HD3  sing N N 285 
LYS   CE  NZ   sing N N 286 
LYS   CE  HE2  sing N N 287 
LYS   CE  HE3  sing N N 288 
LYS   NZ  HZ1  sing N N 289 
LYS   NZ  HZ2  sing N N 290 
LYS   NZ  HZ3  sing N N 291 
LYS   OXT HXT  sing N N 292 
MET   N   CA   sing N N 293 
MET   N   H    sing N N 294 
MET   N   H2   sing N N 295 
MET   CA  C    sing N N 296 
MET   CA  CB   sing N N 297 
MET   CA  HA   sing N N 298 
MET   C   O    doub N N 299 
MET   C   OXT  sing N N 300 
MET   CB  CG   sing N N 301 
MET   CB  HB2  sing N N 302 
MET   CB  HB3  sing N N 303 
MET   CG  SD   sing N N 304 
MET   CG  HG2  sing N N 305 
MET   CG  HG3  sing N N 306 
MET   SD  CE   sing N N 307 
MET   CE  HE1  sing N N 308 
MET   CE  HE2  sing N N 309 
MET   CE  HE3  sing N N 310 
MET   OXT HXT  sing N N 311 
PHE   N   CA   sing N N 312 
PHE   N   H    sing N N 313 
PHE   N   H2   sing N N 314 
PHE   CA  C    sing N N 315 
PHE   CA  CB   sing N N 316 
PHE   CA  HA   sing N N 317 
PHE   C   O    doub N N 318 
PHE   C   OXT  sing N N 319 
PHE   CB  CG   sing N N 320 
PHE   CB  HB2  sing N N 321 
PHE   CB  HB3  sing N N 322 
PHE   CG  CD1  doub Y N 323 
PHE   CG  CD2  sing Y N 324 
PHE   CD1 CE1  sing Y N 325 
PHE   CD1 HD1  sing N N 326 
PHE   CD2 CE2  doub Y N 327 
PHE   CD2 HD2  sing N N 328 
PHE   CE1 CZ   doub Y N 329 
PHE   CE1 HE1  sing N N 330 
PHE   CE2 CZ   sing Y N 331 
PHE   CE2 HE2  sing N N 332 
PHE   CZ  HZ   sing N N 333 
PHE   OXT HXT  sing N N 334 
PRO   N   CA   sing N N 335 
PRO   N   CD   sing N N 336 
PRO   N   H    sing N N 337 
PRO   CA  C    sing N N 338 
PRO   CA  CB   sing N N 339 
PRO   CA  HA   sing N N 340 
PRO   C   O    doub N N 341 
PRO   C   OXT  sing N N 342 
PRO   CB  CG   sing N N 343 
PRO   CB  HB2  sing N N 344 
PRO   CB  HB3  sing N N 345 
PRO   CG  CD   sing N N 346 
PRO   CG  HG2  sing N N 347 
PRO   CG  HG3  sing N N 348 
PRO   CD  HD2  sing N N 349 
PRO   CD  HD3  sing N N 350 
PRO   OXT HXT  sing N N 351 
SER   N   CA   sing N N 352 
SER   N   H    sing N N 353 
SER   N   H2   sing N N 354 
SER   CA  C    sing N N 355 
SER   CA  CB   sing N N 356 
SER   CA  HA   sing N N 357 
SER   C   O    doub N N 358 
SER   C   OXT  sing N N 359 
SER   CB  OG   sing N N 360 
SER   CB  HB2  sing N N 361 
SER   CB  HB3  sing N N 362 
SER   OG  HG   sing N N 363 
SER   OXT HXT  sing N N 364 
THR   N   CA   sing N N 365 
THR   N   H    sing N N 366 
THR   N   H2   sing N N 367 
THR   CA  C    sing N N 368 
THR   CA  CB   sing N N 369 
THR   CA  HA   sing N N 370 
THR   C   O    doub N N 371 
THR   C   OXT  sing N N 372 
THR   CB  OG1  sing N N 373 
THR   CB  CG2  sing N N 374 
THR   CB  HB   sing N N 375 
THR   OG1 HG1  sing N N 376 
THR   CG2 HG21 sing N N 377 
THR   CG2 HG22 sing N N 378 
THR   CG2 HG23 sing N N 379 
THR   OXT HXT  sing N N 380 
TYR   N   CA   sing N N 381 
TYR   N   H    sing N N 382 
TYR   N   H2   sing N N 383 
TYR   CA  C    sing N N 384 
TYR   CA  CB   sing N N 385 
TYR   CA  HA   sing N N 386 
TYR   C   O    doub N N 387 
TYR   C   OXT  sing N N 388 
TYR   CB  CG   sing N N 389 
TYR   CB  HB2  sing N N 390 
TYR   CB  HB3  sing N N 391 
TYR   CG  CD1  doub Y N 392 
TYR   CG  CD2  sing Y N 393 
TYR   CD1 CE1  sing Y N 394 
TYR   CD1 HD1  sing N N 395 
TYR   CD2 CE2  doub Y N 396 
TYR   CD2 HD2  sing N N 397 
TYR   CE1 CZ   doub Y N 398 
TYR   CE1 HE1  sing N N 399 
TYR   CE2 CZ   sing Y N 400 
TYR   CE2 HE2  sing N N 401 
TYR   CZ  OH   sing N N 402 
TYR   OH  HH   sing N N 403 
TYR   OXT HXT  sing N N 404 
VAL   N   CA   sing N N 405 
VAL   N   H    sing N N 406 
VAL   N   H2   sing N N 407 
VAL   CA  C    sing N N 408 
VAL   CA  CB   sing N N 409 
VAL   CA  HA   sing N N 410 
VAL   C   O    doub N N 411 
VAL   C   OXT  sing N N 412 
VAL   CB  CG1  sing N N 413 
VAL   CB  CG2  sing N N 414 
VAL   CB  HB   sing N N 415 
VAL   CG1 HG11 sing N N 416 
VAL   CG1 HG12 sing N N 417 
VAL   CG1 HG13 sing N N 418 
VAL   CG2 HG21 sing N N 419 
VAL   CG2 HG22 sing N N 420 
VAL   CG2 HG23 sing N N 421 
VAL   OXT HXT  sing N N 422 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121054 1 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121052 2 
'Japan Society for the Promotion of Science (JSPS)'        Japan 15H02896      3 
'Japan Society for the Promotion of Science (JSPS)'        Japan 16K13044      4 
'Japan Society for the Promotion of Science (JSPS)'        Japan 18H03190      5 
'Japan Society for the Promotion of Science (JSPS)'        Japan 21H03354      6 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6KXY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YWU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022134 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.006276 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016161 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.019350 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER   A 1 9   ? -5.63005  -9.12007  -7.71032  1.000 45.27392 ? 205 SER   A N   1 
ATOM   2    C CA  . SER   A 1 9   ? -4.90159  -7.85461  -7.59813  1.000 41.87107 ? 205 SER   A CA  1 
ATOM   3    C C   . SER   A 1 9   ? -3.41863  -8.00168  -7.90725  1.000 39.39534 ? 205 SER   A C   1 
ATOM   4    O O   . SER   A 1 9   ? -2.83617  -7.14786  -8.58050  1.000 36.38363 ? 205 SER   A O   1 
ATOM   5    C CB  . SER   A 1 9   ? -5.03890  -7.25026  -6.20749  1.000 51.53798 ? 205 SER   A CB  1 
ATOM   6    O OG  . SER   A 1 9   ? -4.23531  -6.08169  -6.10243  1.000 43.79618 ? 205 SER   A OG  1 
ATOM   7    N N   . LEU   A 1 10  ? -2.79811  -9.05511  -7.37078  1.000 32.25817 ? 206 LEU   A N   1 
ATOM   8    C CA  . LEU   A 1 10  ? -1.42639  -9.36899  -7.76401  1.000 33.99988 ? 206 LEU   A CA  1 
ATOM   9    C C   . LEU   A 1 10  ? -1.35076  -9.61501  -9.26301  1.000 29.00400 ? 206 LEU   A C   1 
ATOM   10   O O   . LEU   A 1 10  ? -0.41135  -9.16242  -9.93223  1.000 29.95517 ? 206 LEU   A O   1 
ATOM   11   C CB  . LEU   A 1 10  ? -0.91701  -10.58800 -6.98890  1.000 31.64701 ? 206 LEU   A CB  1 
ATOM   12   C CG  . LEU   A 1 10  ? 0.42055   -11.21487 -7.39315  1.000 39.01184 ? 206 LEU   A CG  1 
ATOM   13   C CD1 . LEU   A 1 10  ? 1.56359   -10.23579 -7.22922  1.000 35.02741 ? 206 LEU   A CD1 1 
ATOM   14   C CD2 . LEU   A 1 10  ? 0.69984   -12.47809 -6.59579  1.000 35.33059 ? 206 LEU   A CD2 1 
ATOM   15   N N   . ALA   A 1 11  ? -2.34441  -10.31337 -9.81207  1.000 28.10663 ? 207 ALA   A N   1 
ATOM   16   C CA  . ALA   A 1 11  ? -2.36137  -10.55325 -11.25330 1.000 30.30130 ? 207 ALA   A CA  1 
ATOM   17   C C   . ALA   A 1 11  ? -2.47812  -9.24605  -12.02104 1.000 34.54182 ? 207 ALA   A C   1 
ATOM   18   O O   . ALA   A 1 11  ? -1.79137  -9.04082  -13.03344 1.000 32.81331 ? 207 ALA   A O   1 
ATOM   19   C CB  . ALA   A 1 11  ? -3.51288  -11.49230 -11.62213 1.000 28.71361 ? 207 ALA   A CB  1 
ATOM   20   N N   . LYS   A 1 12  ? -3.34403  -8.34306  -11.55308 1.000 32.57365 ? 208 LYS   A N   1 
ATOM   21   C CA  . LYS   A 1 12  ? -3.51806  -7.07956  -12.25450 1.000 36.10647 ? 208 LYS   A CA  1 
ATOM   22   C C   . LYS   A 1 12  ? -2.25467  -6.23003  -12.18564 1.000 30.50587 ? 208 LYS   A C   1 
ATOM   23   O O   . LYS   A 1 12  ? -1.83259  -5.66556  -13.20095 1.000 31.10518 ? 208 LYS   A O   1 
ATOM   24   C CB  . LYS   A 1 12  ? -4.72304  -6.32452  -11.68971 1.000 42.10272 ? 208 LYS   A CB  1 
ATOM   25   C CG  . LYS   A 1 12  ? -5.33373  -5.32984  -12.68607 1.000 47.92967 ? 208 LYS   A CG  1 
ATOM   26   C CD  . LYS   A 1 12  ? -5.87237  -6.02200  -13.93593 1.000 50.27714 ? 208 LYS   A CD  1 
ATOM   27   C CE  . LYS   A 1 12  ? -6.98320  -5.20560  -14.59249 1.000 55.65278 ? 208 LYS   A CE  1 
ATOM   28   N NZ  . LYS   A 1 12  ? -6.77718  -5.08493  -16.06805 1.000 56.49394 ? 208 LYS   A NZ  1 
ATOM   29   N N   . ARG   A 1 13  ? -1.60909  -6.16926  -11.01420 1.000 27.25034 ? 209 ARG   A N   1 
ATOM   30   C CA  . ARG   A 1 13  ? -0.39274  -5.37621  -10.87357 1.000 25.38289 ? 209 ARG   A CA  1 
ATOM   31   C C   . ARG   A 1 13  ? 0.71970   -5.90069  -11.77912 1.000 25.35393 ? 209 ARG   A C   1 
ATOM   32   O O   . ARG   A 1 13  ? 1.46823   -5.11546  -12.37392 1.000 29.03875 ? 209 ARG   A O   1 
ATOM   33   C CB  . ARG   A 1 13  ? 0.07699   -5.37574  -9.41839  1.000 30.91885 ? 209 ARG   A CB  1 
ATOM   34   C CG  . ARG   A 1 13  ? -0.76457  -4.46712  -8.50512  1.000 34.05293 ? 209 ARG   A CG  1 
ATOM   35   C CD  . ARG   A 1 13  ? -0.55139  -4.84744  -7.06104  1.000 36.33532 ? 209 ARG   A CD  1 
ATOM   36   N NE  . ARG   A 1 13  ? 0.68652   -4.27500  -6.55265  1.000 43.69706 ? 209 ARG   A NE  1 
ATOM   37   C CZ  . ARG   A 1 13  ? 1.28442   -4.66796  -5.43701  1.000 39.62117 ? 209 ARG   A CZ  1 
ATOM   38   N NH1 . ARG   A 1 13  ? 0.79232   -5.65036  -4.69885  1.000 41.17034 ? 209 ARG   A NH1 1 
ATOM   39   N NH2 . ARG   A 1 13  ? 2.41296   -4.07458  -5.06439  1.000 46.96633 ? 209 ARG   A NH2 1 
ATOM   40   N N   . ILE   A 1 14  ? 0.84647   -7.21987  -11.89075 1.000 26.78659 ? 210 ILE   A N   1 
ATOM   41   C CA  . ILE   A 1 14  ? 1.89165   -7.77372  -12.75361 1.000 26.53635 ? 210 ILE   A CA  1 
ATOM   42   C C   . ILE   A 1 14  ? 1.58676   -7.46997  -14.21996 1.000 23.97356 ? 210 ILE   A C   1 
ATOM   43   O O   . ILE   A 1 14  ? 2.48165   -7.09149  -14.98589 1.000 21.81551 ? 210 ILE   A O   1 
ATOM   44   C CB  . ILE   A 1 14  ? 2.05719   -9.28014  -12.48996 1.000 23.31845 ? 210 ILE   A CB  1 
ATOM   45   C CG1 . ILE   A 1 14  ? 2.73785   -9.49687  -11.14097 1.000 24.92813 ? 210 ILE   A CG1 1 
ATOM   46   C CG2 . ILE   A 1 14  ? 2.89037   -9.97766  -13.62548 1.000 21.77427 ? 210 ILE   A CG2 1 
ATOM   47   C CD1 . ILE   A 1 14  ? 2.62427   -10.92276 -10.61576 1.000 25.12995 ? 210 ILE   A CD1 1 
ATOM   48   N N   . TYR   A 1 15  ? 0.31635   -7.59992  -14.62653 1.000 23.98037 ? 211 TYR   A N   1 
ATOM   49   C CA  . TYR   A 1 15  ? -0.06826  -7.30331  -16.00996 1.000 28.88564 ? 211 TYR   A CA  1 
ATOM   50   C C   . TYR   A 1 15  ? 0.14349   -5.82594  -16.34697 1.000 29.40683 ? 211 TYR   A C   1 
ATOM   51   O O   . TYR   A 1 15  ? 0.66823   -5.49301  -17.41734 1.000 25.51365 ? 211 TYR   A O   1 
ATOM   52   C CB  . TYR   A 1 15  ? -1.52387  -7.73787  -16.23691 1.000 27.04358 ? 211 TYR   A CB  1 
ATOM   53   C CG  . TYR   A 1 15  ? -2.04854  -7.58775  -17.65586 1.000 26.11759 ? 211 TYR   A CG  1 
ATOM   54   C CD1 . TYR   A 1 15  ? -1.20662  -7.71675  -18.75680 1.000 29.93653 ? 211 TYR   A CD1 1 
ATOM   55   C CD2 . TYR   A 1 15  ? -3.40132  -7.34515  -17.89547 1.000 33.53986 ? 211 TYR   A CD2 1 
ATOM   56   C CE1 . TYR   A 1 15  ? -1.69622  -7.57498  -20.05681 1.000 30.84420 ? 211 TYR   A CE1 1 
ATOM   57   C CE2 . TYR   A 1 15  ? -3.89782  -7.21586  -19.19932 1.000 36.97724 ? 211 TYR   A CE2 1 
ATOM   58   C CZ  . TYR   A 1 15  ? -3.04035  -7.33474  -20.26852 1.000 37.76311 ? 211 TYR   A CZ  1 
ATOM   59   O OH  . TYR   A 1 15  ? -3.51834  -7.20504  -21.55926 1.000 39.09686 ? 211 TYR   A OH  1 
ATOM   60   N N   . GLU   A 1 16  ? -0.23039  -4.91617  -15.43851 1.000 25.49965 ? 212 GLU   A N   1 
ATOM   61   C CA  . GLU   A 1 16  ? 0.01107   -3.50086  -15.70119 1.000 28.42801 ? 212 GLU   A CA  1 
ATOM   62   C C   . GLU   A 1 16  ? 1.49538   -3.19117  -15.80689 1.000 27.05857 ? 212 GLU   A C   1 
ATOM   63   O O   . GLU   A 1 16  ? 1.89942   -2.39006  -16.65642 1.000 27.94864 ? 212 GLU   A O   1 
ATOM   64   C CB  . GLU   A 1 16  ? -0.64480  -2.63250  -14.62591 1.000 32.11758 ? 212 GLU   A CB  1 
ATOM   65   C CG  . GLU   A 1 16  ? -2.10364  -2.96873  -14.45882 1.000 32.54888 ? 212 GLU   A CG  1 
ATOM   66   C CD  . GLU   A 1 16  ? -2.80060  -2.09901  -13.42204 1.000 43.62749 ? 212 GLU   A CD  1 
ATOM   67   O OE1 . GLU   A 1 16  ? -2.15423  -1.72299  -12.42240 1.000 41.39313 ? 212 GLU   A OE1 1 
ATOM   68   O OE2 . GLU   A 1 16  ? -4.01226  -1.84911  -13.59695 1.000 47.77677 ? 212 GLU   A OE2 1 
ATOM   69   N N   . ALA   A 1 17  ? 2.33073   -3.82720  -14.97412 1.000 24.96515 ? 213 ALA   A N   1 
ATOM   70   C CA  . ALA   A 1 17  ? 3.77375   -3.58955  -15.06554 1.000 24.55304 ? 213 ALA   A CA  1 
ATOM   71   C C   . ALA   A 1 17  ? 4.32225   -4.06795  -16.40355 1.000 22.78312 ? 213 ALA   A C   1 
ATOM   72   O O   . ALA   A 1 17  ? 5.23631   -3.46031  -16.97064 1.000 28.68294 ? 213 ALA   A O   1 
ATOM   73   C CB  . ALA   A 1 17  ? 4.51108   -4.29114  -13.92521 1.000 26.82809 ? 213 ALA   A CB  1 
ATOM   74   N N   . TYR   A 1 18  ? 3.78334   -5.17120  -16.90001 1.000 21.77588 ? 214 TYR   A N   1 
ATOM   75   C CA  . TYR   A 1 18  ? 4.17674   -5.70803  -18.19805 1.000 25.88156 ? 214 TYR   A CA  1 
ATOM   76   C C   . TYR   A 1 18  ? 3.79268   -4.74546  -19.31935 1.000 25.93498 ? 214 TYR   A C   1 
ATOM   77   O O   . TYR   A 1 18  ? 4.61147   -4.40932  -20.18740 1.000 26.10333 ? 214 TYR   A O   1 
ATOM   78   C CB  . TYR   A 1 18  ? 3.48355   -7.05848  -18.35215 1.000 21.07496 ? 214 TYR   A CB  1 
ATOM   79   C CG  . TYR   A 1 18  ? 3.58997   -7.75438  -19.69404 1.000 25.85386 ? 214 TYR   A CG  1 
ATOM   80   C CD1 . TYR   A 1 18  ? 4.56547   -8.72391  -19.92794 1.000 22.87840 ? 214 TYR   A CD1 1 
ATOM   81   C CD2 . TYR   A 1 18  ? 2.68745   -7.45544  -20.71666 1.000 29.33121 ? 214 TYR   A CD2 1 
ATOM   82   C CE1 . TYR   A 1 18  ? 4.63061   -9.38976  -21.16211 1.000 26.36334 ? 214 TYR   A CE1 1 
ATOM   83   C CE2 . TYR   A 1 18  ? 2.74670   -8.10587  -21.94662 1.000 29.91828 ? 214 TYR   A CE2 1 
ATOM   84   C CZ  . TYR   A 1 18  ? 3.72288   -9.05941  -22.16424 1.000 31.14641 ? 214 TYR   A CZ  1 
ATOM   85   O OH  . TYR   A 1 18  ? 3.74136   -9.69624  -23.38863 1.000 36.93411 ? 214 TYR   A OH  1 
ATOM   86   N N   . LEU   A 1 19  ? 2.54424   -4.27255  -19.30803 1.000 23.79215 ? 215 LEU   A N   1 
ATOM   87   C CA  . LEU   A 1 19  ? 2.11074   -3.32842  -20.33248 1.000 25.73573 ? 215 LEU   A CA  1 
ATOM   88   C C   . LEU   A 1 19  ? 2.92426   -2.04355  -20.28987 1.000 28.12702 ? 215 LEU   A C   1 
ATOM   89   O O   . LEU   A 1 19  ? 3.19253   -1.42989  -21.33209 1.000 29.40794 ? 215 LEU   A O   1 
ATOM   90   C CB  . LEU   A 1 19  ? 0.61882   -3.02064  -20.15401 1.000 28.54736 ? 215 LEU   A CB  1 
ATOM   91   C CG  . LEU   A 1 19  ? -0.32299  -4.21021  -20.34106 1.000 31.81887 ? 215 LEU   A CG  1 
ATOM   92   C CD1 . LEU   A 1 19  ? -1.76934  -3.83630  -20.05279 1.000 36.00726 ? 215 LEU   A CD1 1 
ATOM   93   C CD2 . LEU   A 1 19  ? -0.17726  -4.74910  -21.74814 1.000 33.12003 ? 215 LEU   A CD2 1 
ATOM   94   N N   . LYS   A 1 20  ? 3.31622   -1.60184  -19.09809 1.000 25.44831 ? 216 LYS   A N   1 
ATOM   95   C CA  . LYS   A 1 20  ? 4.04154   -0.33911  -18.99996 1.000 26.53296 ? 216 LYS   A CA  1 
ATOM   96   C C   . LYS   A 1 20  ? 5.48519   -0.47057  -19.46640 1.000 31.08470 ? 216 LYS   A C   1 
ATOM   97   O O   . LYS   A 1 20  ? 6.02736   0.46047   -20.07413 1.000 32.08906 ? 216 LYS   A O   1 
ATOM   98   C CB  . LYS   A 1 20  ? 4.01415   0.20511   -17.56145 1.000 30.92756 ? 216 LYS   A CB  1 
ATOM   99   C CG  . LYS   A 1 20  ? 2.62470   0.54619   -17.01103 1.000 38.52957 ? 216 LYS   A CG  1 
ATOM   100  C CD  . LYS   A 1 20  ? 2.73943   1.30412   -15.67816 1.000 42.99072 ? 216 LYS   A CD  1 
ATOM   101  C CE  . LYS   A 1 20  ? 1.52641   1.07944   -14.76660 1.000 46.65016 ? 216 LYS   A CE  1 
ATOM   102  N NZ  . LYS   A 1 20  ? 0.28292   1.70376   -15.32126 1.000 53.17689 ? 216 LYS   A NZ  1 
ATOM   103  N N   . ASN   A 1 21  ? 6.13366   -1.60544  -19.18577 1.000 23.50423 ? 217 ASN   A N   1 
ATOM   104  C CA  . ASN   A 1 21  ? 7.58157   -1.67022  -19.30059 1.000 23.23364 ? 217 ASN   A CA  1 
ATOM   105  C C   . ASN   A 1 21  ? 8.09628   -2.28962  -20.59239 1.000 25.74480 ? 217 ASN   A C   1 
ATOM   106  O O   . ASN   A 1 21  ? 9.28122   -2.11798  -20.89384 1.000 26.43364 ? 217 ASN   A O   1 
ATOM   107  C CB  . ASN   A 1 21  ? 8.17292   -2.43755  -18.11699 1.000 26.93158 ? 217 ASN   A CB  1 
ATOM   108  C CG  . ASN   A 1 21  ? 8.19274   -1.59532  -16.85257 1.000 32.12265 ? 217 ASN   A CG  1 
ATOM   109  O OD1 . ASN   A 1 21  ? 8.91011   -0.59752  -16.77798 1.000 32.14900 ? 217 ASN   A OD1 1 
ATOM   110  N ND2 . ASN   A 1 21  ? 7.38031   -1.97030  -15.87324 1.000 27.08131 ? 217 ASN   A ND2 1 
ATOM   111  N N   . PHE   A 1 22  ? 7.27713   -3.00885  -21.34612 1.000 23.62567 ? 218 PHE   A N   1 
ATOM   112  C CA  . PHE   A 1 22  ? 7.73866   -3.66900  -22.57132 1.000 22.43591 ? 218 PHE   A CA  1 
ATOM   113  C C   . PHE   A 1 22  ? 7.19161   -2.93318  -23.78946 1.000 26.52628 ? 218 PHE   A C   1 
ATOM   114  O O   . PHE   A 1 22  ? 5.97025   -2.80313  -23.94403 1.000 24.58611 ? 218 PHE   A O   1 
ATOM   115  C CB  . PHE   A 1 22  ? 7.32358   -5.13920  -22.58803 1.000 18.16733 ? 218 PHE   A CB  1 
ATOM   116  C CG  . PHE   A 1 22  ? 7.98224   -5.94826  -21.49156 1.000 21.79810 ? 218 PHE   A CG  1 
ATOM   117  C CD1 . PHE   A 1 22  ? 9.36666   -6.10508  -21.46985 1.000 26.72076 ? 218 PHE   A CD1 1 
ATOM   118  C CD2 . PHE   A 1 22  ? 7.23436   -6.48197  -20.45961 1.000 23.33593 ? 218 PHE   A CD2 1 
ATOM   119  C CE1 . PHE   A 1 22  ? 9.99040   -6.80013  -20.43590 1.000 29.28984 ? 218 PHE   A CE1 1 
ATOM   120  C CE2 . PHE   A 1 22  ? 7.83754   -7.19885  -19.42810 1.000 24.08278 ? 218 PHE   A CE2 1 
ATOM   121  C CZ  . PHE   A 1 22  ? 9.23153   -7.35862  -19.41822 1.000 27.18462 ? 218 PHE   A CZ  1 
ATOM   122  N N   . ASN   A 1 23  ? 8.09618   -2.48231  -24.66455 1.000 27.75526 ? 219 ASN   A N   1 
ATOM   123  C CA  . ASN   A 1 23  ? 7.68095   -1.71173  -25.83489 1.000 27.06364 ? 219 ASN   A CA  1 
ATOM   124  C C   . ASN   A 1 23  ? 6.86114   -2.55174  -26.80837 1.000 27.35298 ? 219 ASN   A C   1 
ATOM   125  O O   . ASN   A 1 23  ? 6.02659   -2.01597  -27.54533 1.000 30.34633 ? 219 ASN   A O   1 
ATOM   126  C CB  . ASN   A 1 23  ? 8.91043   -1.13339  -26.54469 1.000 27.58785 ? 219 ASN   A CB  1 
ATOM   127  C CG  . ASN   A 1 23  ? 9.70550   -2.20166  -27.28807 1.000 32.99586 ? 219 ASN   A CG  1 
ATOM   128  O OD1 . ASN   A 1 23  ? 9.35726   -2.58221  -28.41126 1.000 35.09352 ? 219 ASN   A OD1 1 
ATOM   129  N ND2 . ASN   A 1 23  ? 10.77663  -2.69757  -26.66139 1.000 33.44140 ? 219 ASN   A ND2 1 
ATOM   130  N N   . MET   A 1 24  ? 7.07379   -3.85914  -26.82731 1.000 25.98070 ? 220 MET   A N   1 
ATOM   131  C CA  . MET   A 1 24  ? 6.41085   -4.72849  -27.77537 1.000 31.34265 ? 220 MET   A CA  1 
ATOM   132  C C   . MET   A 1 24  ? 5.63186   -5.73062  -26.93480 1.000 28.31995 ? 220 MET   A C   1 
ATOM   133  O O   . MET   A 1 24  ? 6.08604   -6.12652  -25.85446 1.000 29.37381 ? 220 MET   A O   1 
ATOM   134  C CB  . MET   A 1 24  ? 7.44062   -5.44412  -28.66581 1.000 31.11991 ? 220 MET   A CB  1 
ATOM   135  C CG  . MET   A 1 24  ? 6.92669   -6.34615  -29.77962 1.000 32.76201 ? 220 MET   A CG  1 
ATOM   136  S SD  . MET   A 1 24  ? 5.59348   -5.56859  -30.72855 1.000 33.56922 ? 220 MET   A SD  1 
ATOM   137  C CE  . MET   A 1 24  ? 6.58625   -4.66554  -31.92140 1.000 36.26415 ? 220 MET   A CE  1 
ATOM   138  N N   . ASN   A 1 25  ? 4.44949   -6.10611  -27.39617 1.000 29.39374 ? 221 ASN   A N   1 
ATOM   139  C CA  . ASN   A 1 25  ? 3.68794   -7.16310  -26.74808 1.000 30.49053 ? 221 ASN   A CA  1 
ATOM   140  C C   . ASN   A 1 25  ? 2.89892   -7.90557  -27.81281 1.000 36.19404 ? 221 ASN   A C   1 
ATOM   141  O O   . ASN   A 1 25  ? 2.92597   -7.54988  -28.99536 1.000 29.33506 ? 221 ASN   A O   1 
ATOM   142  C CB  . ASN   A 1 25  ? 2.78774   -6.61119  -25.64202 1.000 28.32818 ? 221 ASN   A CB  1 
ATOM   143  C CG  . ASN   A 1 25  ? 1.79740   -5.56810  -26.14297 1.000 37.75603 ? 221 ASN   A CG  1 
ATOM   144  O OD1 . ASN   A 1 25  ? 1.11758   -5.74307  -27.16275 1.000 34.27970 ? 221 ASN   A OD1 1 
ATOM   145  N ND2 . ASN   A 1 25  ? 1.68103   -4.47891  -25.38680 1.000 38.19855 ? 221 ASN   A ND2 1 
ATOM   146  N N   . LYS   A 1 26  ? 2.17531   -8.93874  -27.38388 1.000 23.85694 ? 222 LYS   A N   1 
ATOM   147  C CA  . LYS   A 1 26  ? 1.58985   -9.84286  -28.36276 1.000 28.05514 ? 222 LYS   A CA  1 
ATOM   148  C C   . LYS   A 1 26  ? 0.49408   -9.16151  -29.17971 1.000 31.70102 ? 222 LYS   A C   1 
ATOM   149  O O   . LYS   A 1 26  ? 0.38853   -9.39682  -30.38792 1.000 28.87435 ? 222 LYS   A O   1 
ATOM   150  C CB  . LYS   A 1 26  ? 1.07111   -11.09868 -27.67712 1.000 31.17578 ? 222 LYS   A CB  1 
ATOM   151  C CG  . LYS   A 1 26  ? 0.87614   -12.23997 -28.64255 1.000 32.91505 ? 222 LYS   A CG  1 
ATOM   152  C CD  . LYS   A 1 26  ? 0.73301   -13.55772 -27.91391 1.000 32.71921 ? 222 LYS   A CD  1 
ATOM   153  C CE  . LYS   A 1 26  ? 0.42648   -14.65923 -28.90272 1.000 31.12557 ? 222 LYS   A CE  1 
ATOM   154  N NZ  . LYS   A 1 26  ? 0.50397   -15.96463 -28.22695 1.000 27.06218 ? 222 LYS   A NZ  1 
ATOM   155  N N   . VAL   A 1 27  ? -0.32668  -8.31151  -28.55147 1.000 29.48530 ? 223 VAL   A N   1 
ATOM   156  C CA  . VAL   A 1 27  ? -1.36124  -7.59805  -29.30571 1.000 34.95723 ? 223 VAL   A CA  1 
ATOM   157  C C   . VAL   A 1 27  ? -0.72921  -6.66090  -30.33268 1.000 32.51453 ? 223 VAL   A C   1 
ATOM   158  O O   . VAL   A 1 27  ? -1.10339  -6.66876  -31.51319 1.000 32.14409 ? 223 VAL   A O   1 
ATOM   159  C CB  . VAL   A 1 27  ? -2.30879  -6.83867  -28.35700 1.000 38.37636 ? 223 VAL   A CB  1 
ATOM   160  C CG1 . VAL   A 1 27  ? -3.04770  -5.73939  -29.10986 1.000 44.48762 ? 223 VAL   A CG1 1 
ATOM   161  C CG2 . VAL   A 1 27  ? -3.29857  -7.78721  -27.74721 1.000 39.65442 ? 223 VAL   A CG2 1 
ATOM   162  N N   . LYS   A 1 28  ? 0.23009   -5.83157  -29.90130 1.000 30.26419 ? 224 LYS   A N   1 
ATOM   163  C CA  . LYS   A 1 28  ? 0.89258   -4.92367  -30.84223 1.000 32.73931 ? 224 LYS   A CA  1 
ATOM   164  C C   . LYS   A 1 28  ? 1.56866   -5.70220  -31.97373 1.000 36.17442 ? 224 LYS   A C   1 
ATOM   165  O O   . LYS   A 1 28  ? 1.52758   -5.28549  -33.14307 1.000 32.56925 ? 224 LYS   A O   1 
ATOM   166  C CB  . LYS   A 1 28  ? 1.91234   -4.03695  -30.11267 1.000 33.03929 ? 224 LYS   A CB  1 
ATOM   167  C CG  . LYS   A 1 28  ? 1.30423   -3.06428  -29.08171 1.000 41.42068 ? 224 LYS   A CG  1 
ATOM   168  C CD  . LYS   A 1 28  ? 2.33929   -2.31523  -28.20825 1.000 40.33688 ? 224 LYS   A CD  1 
ATOM   169  C CE  . LYS   A 1 28  ? 2.81054   -0.99069  -28.81375 1.000 50.06697 ? 224 LYS   A CE  1 
ATOM   170  N NZ  . LYS   A 1 28  ? 4.10836   -0.50682  -28.22575 1.000 42.45539 ? 224 LYS   A NZ  1 
ATOM   171  N N   . ALA   A 1 29  ? 2.18216   -6.84400  -31.65191 1.000 26.85473 ? 225 ALA   A N   1 
ATOM   172  C CA  . ALA   A 1 29  ? 2.86117   -7.63283  -32.68830 1.000 29.17532 ? 225 ALA   A CA  1 
ATOM   173  C C   . ALA   A 1 29  ? 1.86769   -8.20297  -33.69395 1.000 33.51050 ? 225 ALA   A C   1 
ATOM   174  O O   . ALA   A 1 29  ? 2.13784   -8.22389  -34.90557 1.000 33.09737 ? 225 ALA   A O   1 
ATOM   175  C CB  . ALA   A 1 29  ? 3.67057   -8.76430  -32.04319 1.000 24.83280 ? 225 ALA   A CB  1 
ATOM   176  N N   . ARG   A 1 30  ? 0.71793   -8.68622  -33.20679 1.000 31.25294 ? 226 ARG   A N   1 
ATOM   177  C CA  . ARG   A 1 30  ? -0.31316  -9.23354  -34.09059 1.000 39.54241 ? 226 ARG   A CA  1 
ATOM   178  C C   . ARG   A 1 30  ? -0.91934  -8.15392  -34.98472 1.000 38.35759 ? 226 ARG   A C   1 
ATOM   179  O O   . ARG   A 1 30  ? -1.24745  -8.41545  -36.15072 1.000 42.39825 ? 226 ARG   A O   1 
ATOM   180  C CB  . ARG   A 1 30  ? -1.40262  -9.91526  -33.25600 1.000 39.80225 ? 226 ARG   A CB  1 
ATOM   181  C CG  . ARG   A 1 30  ? -1.04744  -11.30144 -32.70415 1.000 41.57848 ? 226 ARG   A CG  1 
ATOM   182  C CD  . ARG   A 1 30  ? -0.03254  -12.06877 -33.56639 1.000 52.10332 ? 226 ARG   A CD  1 
ATOM   183  N NE  . ARG   A 1 30  ? 0.73863   -13.03852 -32.78619 1.000 54.77161 ? 226 ARG   A NE  1 
ATOM   184  C CZ  . ARG   A 1 30  ? 1.96662   -13.45417 -33.08077 1.000 53.05698 ? 226 ARG   A CZ  1 
ATOM   185  N NH1 . ARG   A 1 30  ? 2.62864   -14.27562 -32.28273 1.000 47.41767 ? 226 ARG   A NH1 1 
ATOM   186  N NH2 . ARG   A 1 30  ? 2.53851   -13.05120 -34.21358 1.000 52.27733 ? 226 ARG   A NH2 1 
ATOM   187  N N   . VAL   A 1 31  ? -1.08743  -6.93866  -34.45835 1.000 37.49769 ? 227 VAL   A N   1 
ATOM   188  C CA  . VAL   A 1 31  ? -1.54613  -5.82830  -35.29222 1.000 40.98678 ? 227 VAL   A CA  1 
ATOM   189  C C   . VAL   A 1 31  ? -0.57337  -5.58662  -36.44224 1.000 43.95722 ? 227 VAL   A C   1 
ATOM   190  O O   . VAL   A 1 31  ? -0.97975  -5.42698  -37.59915 1.000 48.69523 ? 227 VAL   A O   1 
ATOM   191  C CB  . VAL   A 1 31  ? -1.74443  -4.56181  -34.44150 1.000 41.52749 ? 227 VAL   A CB  1 
ATOM   192  C CG1 . VAL   A 1 31  ? -2.07193  -3.37698  -35.32781 1.000 44.84390 ? 227 VAL   A CG1 1 
ATOM   193  C CG2 . VAL   A 1 31  ? -2.86608  -4.77533  -33.44785 1.000 46.34400 ? 227 VAL   A CG2 1 
ATOM   194  N N   . ILE   A 1 32  ? 0.72723   -5.56913  -36.14586 1.000 35.20608 ? 228 ILE   A N   1 
ATOM   195  C CA  . ILE   A 1 32  ? 1.71622   -5.32214  -37.19254 1.000 35.26088 ? 228 ILE   A CA  1 
ATOM   196  C C   . ILE   A 1 32  ? 1.76498   -6.48662  -38.17755 1.000 40.75532 ? 228 ILE   A C   1 
ATOM   197  O O   . ILE   A 1 32  ? 1.85071   -6.28137  -39.39718 1.000 41.93223 ? 228 ILE   A O   1 
ATOM   198  C CB  . ILE   A 1 32  ? 3.09889   -5.05377  -36.56744 1.000 28.52116 ? 228 ILE   A CB  1 
ATOM   199  C CG1 . ILE   A 1 32  ? 3.06942   -3.78933  -35.70238 1.000 35.28798 ? 228 ILE   A CG1 1 
ATOM   200  C CG2 . ILE   A 1 32  ? 4.17375   -4.96258  -37.65007 1.000 30.39543 ? 228 ILE   A CG2 1 
ATOM   201  C CD1 . ILE   A 1 32  ? 4.36443   -3.52852  -34.91663 1.000 32.74145 ? 228 ILE   A CD1 1 
ATOM   202  N N   . LEU   A 1 33  ? 1.70955   -7.72233  -37.67667 1.000 35.00477 ? 229 LEU   A N   1 
ATOM   203  C CA  . LEU   A 1 33  ? 1.96042   -8.89652  -38.50467 1.000 37.79974 ? 229 LEU   A CA  1 
ATOM   204  C C   . LEU   A 1 33  ? 0.77151   -9.28729  -39.36861 1.000 52.05064 ? 229 LEU   A C   1 
ATOM   205  O O   . LEU   A 1 33  ? 0.79295   -10.37444 -39.95754 1.000 59.74912 ? 229 LEU   A O   1 
ATOM   206  C CB  . LEU   A 1 33  ? 2.37347   -10.08753 -37.64031 1.000 36.57209 ? 229 LEU   A CB  1 
ATOM   207  C CG  . LEU   A 1 33  ? 3.83003   -10.06212 -37.17883 1.000 35.38582 ? 229 LEU   A CG  1 
ATOM   208  C CD1 . LEU   A 1 33  ? 4.08874   -11.09965 -36.12074 1.000 34.40227 ? 229 LEU   A CD1 1 
ATOM   209  C CD2 . LEU   A 1 33  ? 4.76347   -10.26865 -38.36554 1.000 42.61995 ? 229 LEU   A CD2 1 
ATOM   210  N N   . SER   A 1 34  ? -0.24578  -8.43692  -39.47061 1.000 50.36085 ? 230 SER   A N   1 
ATOM   211  C CA  . SER   A 1 34  ? -1.38938  -8.70867  -40.33367 1.000 55.31911 ? 230 SER   A CA  1 
ATOM   212  C C   . SER   A 1 34  ? -1.45160  -7.71725  -41.50365 1.000 59.63390 ? 230 SER   A C   1 
ATOM   213  O O   . SER   A 1 34  ? -2.37501  -6.90497  -41.60853 1.000 63.18059 ? 230 SER   A O   1 
ATOM   214  C CB  . SER   A 1 34  ? -2.67983  -8.66788  -39.51828 1.000 50.79589 ? 230 SER   A CB  1 
ATOM   215  O OG  . SER   A 1 34  ? -3.00521  -7.34322  -39.12965 1.000 53.25062 ? 230 SER   A OG  1 
ATOM   216  N N   . PRO   A 1 41  ? 3.70550   -1.09007  -42.59237 1.000 52.24259 ? 237 PRO   A N   1 
ATOM   217  C CA  . PRO   A 1 41  ? 4.09956   -2.35938  -43.22841 1.000 48.55609 ? 237 PRO   A CA  1 
ATOM   218  C C   . PRO   A 1 41  ? 5.58938   -2.63121  -43.02350 1.000 41.63887 ? 237 PRO   A C   1 
ATOM   219  O O   . PRO   A 1 41  ? 6.40908   -1.90208  -43.59566 1.000 37.44917 ? 237 PRO   A O   1 
ATOM   220  C CB  . PRO   A 1 41  ? 3.79049   -2.14918  -44.71591 1.000 49.21759 ? 237 PRO   A CB  1 
ATOM   221  C CG  . PRO   A 1 41  ? 3.11467   -0.83047  -44.83647 1.000 56.25834 ? 237 PRO   A CG  1 
ATOM   222  C CD  . PRO   A 1 41  ? 3.18613   -0.09240  -43.54123 1.000 49.81961 ? 237 PRO   A CD  1 
ATOM   223  N N   . PRO   A 1 42  ? 5.93182   -3.65114  -42.23095 1.000 35.59367 ? 238 PRO   A N   1 
ATOM   224  C CA  . PRO   A 1 42  ? 7.34564   -3.87554  -41.90182 1.000 33.04342 ? 238 PRO   A CA  1 
ATOM   225  C C   . PRO   A 1 42  ? 8.15400   -4.21125  -43.14111 1.000 32.81824 ? 238 PRO   A C   1 
ATOM   226  O O   . PRO   A 1 42  ? 7.71071   -4.96603  -44.00786 1.000 35.13790 ? 238 PRO   A O   1 
ATOM   227  C CB  . PRO   A 1 42  ? 7.31948   -5.05617  -40.92306 1.000 35.22038 ? 238 PRO   A CB  1 
ATOM   228  C CG  . PRO   A 1 42  ? 5.94476   -5.61470  -40.96244 1.000 42.27516 ? 238 PRO   A CG  1 
ATOM   229  C CD  . PRO   A 1 42  ? 5.06920   -4.77541  -41.83913 1.000 38.89430 ? 238 PRO   A CD  1 
ATOM   230  N N   . PHE   A 1 43  ? 9.36086   -3.65920  -43.19117 1.000 29.95527 ? 239 PHE   A N   1 
ATOM   231  C CA  . PHE   A 1 43  ? 10.29977  -3.95762  -44.26427 1.000 37.94454 ? 239 PHE   A CA  1 
ATOM   232  C C   . PHE   A 1 43  ? 10.84206  -5.37901  -44.12664 1.000 35.90770 ? 239 PHE   A C   1 
ATOM   233  O O   . PHE   A 1 43  ? 11.31393  -5.77369  -43.05934 1.000 30.39236 ? 239 PHE   A O   1 
ATOM   234  C CB  . PHE   A 1 43  ? 11.43385  -2.94046  -44.23772 1.000 30.47955 ? 239 PHE   A CB  1 
ATOM   235  C CG  . PHE   A 1 43  ? 12.42765  -3.12227  -45.33365 1.000 36.17834 ? 239 PHE   A CG  1 
ATOM   236  C CD1 . PHE   A 1 43  ? 13.59760  -3.81980  -45.11083 1.000 34.92648 ? 239 PHE   A CD1 1 
ATOM   237  C CD2 . PHE   A 1 43  ? 12.17168  -2.62672  -46.59896 1.000 37.24844 ? 239 PHE   A CD2 1 
ATOM   238  C CE1 . PHE   A 1 43  ? 14.51243  -4.00075  -46.13005 1.000 37.59696 ? 239 PHE   A CE1 1 
ATOM   239  C CE2 . PHE   A 1 43  ? 13.08270  -2.80304  -47.62317 1.000 40.59643 ? 239 PHE   A CE2 1 
ATOM   240  C CZ  . PHE   A 1 43  ? 14.24939  -3.49375  -47.38955 1.000 40.13278 ? 239 PHE   A CZ  1 
ATOM   241  N N   . VAL   A 1 44  ? 10.77893  -6.15337  -45.20304 1.000 31.41084 ? 240 VAL   A N   1 
ATOM   242  C CA  . VAL   A 1 44  ? 11.11475  -7.57202  -45.13730 1.000 30.93245 ? 240 VAL   A CA  1 
ATOM   243  C C   . VAL   A 1 44  ? 12.57483  -7.76946  -45.50928 1.000 34.92968 ? 240 VAL   A C   1 
ATOM   244  O O   . VAL   A 1 44  ? 13.01460  -7.35823  -46.59239 1.000 32.54229 ? 240 VAL   A O   1 
ATOM   245  C CB  . VAL   A 1 44  ? 10.20435  -8.40975  -46.04498 1.000 32.49668 ? 240 VAL   A CB  1 
ATOM   246  C CG1 . VAL   A 1 44  ? 10.66392  -9.86844  -46.03245 1.000 34.22523 ? 240 VAL   A CG1 1 
ATOM   247  C CG2 . VAL   A 1 44  ? 8.75164   -8.28221  -45.58452 1.000 30.44880 ? 240 VAL   A CG2 1 
ATOM   248  N N   . ILE   A 1 45  ? 13.31272  -8.42163  -44.61607 1.000 29.65810 ? 241 ILE   A N   1 
ATOM   249  C CA  . ILE   A 1 45  ? 14.70614  -8.79632  -44.82444 1.000 28.21314 ? 241 ILE   A CA  1 
ATOM   250  C C   . ILE   A 1 45  ? 14.73359  -10.27825 -45.17221 1.000 31.80423 ? 241 ILE   A C   1 
ATOM   251  O O   . ILE   A 1 45  ? 14.48227  -11.14497 -44.32443 1.000 26.50376 ? 241 ILE   A O   1 
ATOM   252  C CB  . ILE   A 1 45  ? 15.56036  -8.49674  -43.58758 1.000 28.45331 ? 241 ILE   A CB  1 
ATOM   253  C CG1 . ILE   A 1 45  ? 15.59974  -6.99793  -43.31428 1.000 24.22708 ? 241 ILE   A CG1 1 
ATOM   254  C CG2 . ILE   A 1 45  ? 16.96288  -9.05477  -43.74611 1.000 24.75751 ? 241 ILE   A CG2 1 
ATOM   255  C CD1 . ILE   A 1 45  ? 15.89995  -6.66619  -41.85324 1.000 29.04732 ? 241 ILE   A CD1 1 
ATOM   256  N N   . HIS   A 1 46  ? 15.06511  -10.58325 -46.42383 1.000 30.91496 ? 242 HIS   A N   1 
ATOM   257  C CA  . HIS   A 1 46  ? 15.02473  -11.96173 -46.87983 1.000 30.91806 ? 242 HIS   A CA  1 
ATOM   258  C C   . HIS   A 1 46  ? 16.24787  -12.35904 -47.69545 1.000 32.05869 ? 242 HIS   A C   1 
ATOM   259  O O   . HIS   A 1 46  ? 16.35755  -13.53032 -48.07001 1.000 28.04085 ? 242 HIS   A O   1 
ATOM   260  C CB  . HIS   A 1 46  ? 13.75674  -12.20341 -47.71507 1.000 32.73674 ? 242 HIS   A CB  1 
ATOM   261  C CG  . HIS   A 1 46  ? 13.72970  -11.42642 -48.99547 1.000 33.69883 ? 242 HIS   A CG  1 
ATOM   262  N ND1 . HIS   A 1 46  ? 14.18422  -11.94699 -50.18982 1.000 32.74181 ? 242 HIS   A ND1 1 
ATOM   263  C CD2 . HIS   A 1 46  ? 13.30187  -10.17025 -49.26987 1.000 35.95231 ? 242 HIS   A CD2 1 
ATOM   264  C CE1 . HIS   A 1 46  ? 14.03651  -11.04584 -51.14491 1.000 36.64310 ? 242 HIS   A CE1 1 
ATOM   265  N NE2 . HIS   A 1 46  ? 13.50841  -9.95637  -50.61511 1.000 38.37049 ? 242 HIS   A NE2 1 
ATOM   266  N N   . ASP   A 1 47  ? 17.17101  -11.44298 -47.95740 1.000 30.31468 ? 243 ASP   A N   1 
ATOM   267  C CA  . ASP   A 1 47  ? 18.41312  -11.76333 -48.66105 1.000 31.08052 ? 243 ASP   A CA  1 
ATOM   268  C C   . ASP   A 1 47  ? 19.43537  -10.68943 -48.31282 1.000 35.03107 ? 243 ASP   A C   1 
ATOM   269  O O   . ASP   A 1 47  ? 19.15674  -9.79306  -47.50996 1.000 31.79307 ? 243 ASP   A O   1 
ATOM   270  C CB  . ASP   A 1 47  ? 18.17954  -11.88926 -50.17475 1.000 34.56529 ? 243 ASP   A CB  1 
ATOM   271  C CG  . ASP   A 1 47  ? 17.59539  -10.63122 -50.80558 1.000 37.93004 ? 243 ASP   A CG  1 
ATOM   272  O OD1 . ASP   A 1 47  ? 17.54529  -9.55629  -50.16767 1.000 34.49064 ? 243 ASP   A OD1 1 
ATOM   273  O OD2 . ASP   A 1 47  ? 17.21629  -10.70616 -51.99939 1.000 43.40522 ? 243 ASP   A OD2 1 
ATOM   274  N N   . MET   A 1 48  ? 20.62102  -10.76881 -48.93422 1.000 31.52439 ? 244 MET   A N   1 
ATOM   275  C CA  . MET   A 1 48  ? 21.68426  -9.80620  -48.65408 1.000 32.05942 ? 244 MET   A CA  1 
ATOM   276  C C   . MET   A 1 48  ? 21.30518  -8.40039  -49.09086 1.000 30.55037 ? 244 MET   A C   1 
ATOM   277  O O   . MET   A 1 48  ? 21.68373  -7.42415  -48.43153 1.000 33.71093 ? 244 MET   A O   1 
ATOM   278  C CB  . MET   A 1 48  ? 22.99112  -10.23424 -49.33582 1.000 32.13048 ? 244 MET   A CB  1 
ATOM   279  C CG  . MET   A 1 48  ? 23.85631  -11.23629 -48.55036 1.000 39.34605 ? 244 MET   A CG  1 
ATOM   280  S SD  . MET   A 1 48  ? 23.71501  -11.11568 -46.73843 1.000 40.83850 ? 244 MET   A SD  1 
ATOM   281  C CE  . MET   A 1 48  ? 24.45419  -12.67229 -46.23075 1.000 34.95506 ? 244 MET   A CE  1 
ATOM   282  N N   . GLU   A 1 49  ? 20.60123  -8.27343  -50.22217 1.000 34.30411 ? 245 GLU   A N   1 
ATOM   283  C CA  . GLU   A 1 49  ? 20.23555  -6.95781  -50.74420 1.000 34.94081 ? 245 GLU   A CA  1 
ATOM   284  C C   . GLU   A 1 49  ? 19.30864  -6.21995  -49.78632 1.000 31.48190 ? 245 GLU   A C   1 
ATOM   285  O O   . GLU   A 1 49  ? 19.55315  -5.06530  -49.42746 1.000 29.86628 ? 245 GLU   A O   1 
ATOM   286  C CB  . GLU   A 1 49  ? 19.55950  -7.09988  -52.10927 1.000 37.01638 ? 245 GLU   A CB  1 
ATOM   287  C CG  . GLU   A 1 49  ? 19.21737  -5.76515  -52.75092 1.000 43.42909 ? 245 GLU   A CG  1 
ATOM   288  C CD  . GLU   A 1 49  ? 18.10254  -5.86022  -53.78618 1.000 43.68101 ? 245 GLU   A CD  1 
ATOM   289  O OE1 . GLU   A 1 49  ? 17.24887  -6.77668  -53.70011 1.000 53.44640 ? 245 GLU   A OE1 1 
ATOM   290  O OE2 . GLU   A 1 49  ? 18.09570  -5.01137  -54.69902 1.000 46.90013 ? 245 GLU   A OE2 1 
ATOM   291  N N   . THR   A 1 50  ? 18.21235  -6.86204  -49.40401 1.000 32.34002 ? 246 THR   A N   1 
ATOM   292  C CA  . THR   A 1 50  ? 17.29173  -6.24106  -48.45905 1.000 34.17158 ? 246 THR   A CA  1 
ATOM   293  C C   . THR   A 1 50  ? 17.87551  -6.11407  -47.05289 1.000 30.43965 ? 246 THR   A C   1 
ATOM   294  O O   . THR   A 1 50  ? 17.53352  -5.16173  -46.34527 1.000 30.18596 ? 246 THR   A O   1 
ATOM   295  C CB  . THR   A 1 50  ? 15.95813  -6.99281  -48.47943 1.000 32.11020 ? 246 THR   A CB  1 
ATOM   296  O OG1 . THR   A 1 50  ? 16.14696  -8.33261  -48.00675 1.000 29.73046 ? 246 THR   A OG1 1 
ATOM   297  C CG2 . THR   A 1 50  ? 15.31738  -6.96149  -49.88143 1.000 38.06676 ? 246 THR   A CG2 1 
ATOM   298  N N   . LEU   A 1 51  ? 18.77106  -7.00976  -46.62681 1.000 27.47107 ? 247 LEU   A N   1 
ATOM   299  C CA  . LEU   A 1 51  ? 19.45948  -6.74821  -45.36085 1.000 29.81034 ? 247 LEU   A CA  1 
ATOM   300  C C   . LEU   A 1 51  ? 20.22918  -5.43883  -45.43116 1.000 35.73075 ? 247 LEU   A C   1 
ATOM   301  O O   . LEU   A 1 51  ? 20.21420  -4.64540  -44.47967 1.000 28.84962 ? 247 LEU   A O   1 
ATOM   302  C CB  . LEU   A 1 51  ? 20.40553  -7.88650  -44.98944 1.000 29.85031 ? 247 LEU   A CB  1 
ATOM   303  C CG  . LEU   A 1 51  ? 21.30885  -7.60122  -43.79182 1.000 30.28336 ? 247 LEU   A CG  1 
ATOM   304  C CD1 . LEU   A 1 51  ? 20.47565  -7.53920  -42.46443 1.000 23.82128 ? 247 LEU   A CD1 1 
ATOM   305  C CD2 . LEU   A 1 51  ? 22.39805  -8.64596  -43.68171 1.000 31.77522 ? 247 LEU   A CD2 1 
ATOM   306  N N   A CYS   A 1 52  ? 20.89598  -5.18338  -46.55933 0.490 27.71961 ? 248 CYS   A N   1 
ATOM   307  N N   B CYS   A 1 52  ? 20.90965  -5.18936  -46.55636 0.510 27.86826 ? 248 CYS   A N   1 
ATOM   308  C CA  A CYS   A 1 52  ? 21.65624  -3.94864  -46.69259 0.490 30.00186 ? 248 CYS   A CA  1 
ATOM   309  C CA  B CYS   A 1 52  ? 21.66175  -3.94859  -46.69339 0.510 30.01614 ? 248 CYS   A CA  1 
ATOM   310  C C   A CYS   A 1 52  ? 20.74683  -2.72821  -46.71917 0.490 30.47222 ? 248 CYS   A C   1 
ATOM   311  C C   B CYS   A 1 52  ? 20.74011  -2.73526  -46.70133 0.510 30.42196 ? 248 CYS   A C   1 
ATOM   312  O O   A CYS   A 1 52  ? 21.08781  -1.68774  -46.14360 0.490 32.89469 ? 248 CYS   A O   1 
ATOM   313  O O   B CYS   A 1 52  ? 21.06472  -1.70691  -46.09497 0.510 32.90692 ? 248 CYS   A O   1 
ATOM   314  C CB  A CYS   A 1 52  ? 22.52662  -4.00817  -47.94622 0.490 31.49844 ? 248 CYS   A CB  1 
ATOM   315  C CB  B CYS   A 1 52  ? 22.52011  -3.98068  -47.96213 0.510 31.50824 ? 248 CYS   A CB  1 
ATOM   316  S SG  A CYS   A 1 52  ? 23.92346  -5.10433  -47.73855 0.490 33.39795 ? 248 CYS   A SG  1 
ATOM   317  S SG  B CYS   A 1 52  ? 23.65742  -2.56902  -48.10527 0.510 37.56048 ? 248 CYS   A SG  1 
ATOM   318  N N   . MET   A 1 53  ? 19.58761  -2.82515  -47.37522 1.000 26.83199 ? 249 MET   A N   1 
ATOM   319  C CA  . MET   A 1 53  ? 18.69167  -1.66945  -47.40795 1.000 29.17191 ? 249 MET   A CA  1 
ATOM   320  C C   . MET   A 1 53  ? 18.11043  -1.38658  -46.02801 1.000 31.36810 ? 249 MET   A C   1 
ATOM   321  O O   . MET   A 1 53  ? 18.02520  -0.22367  -45.61003 1.000 31.94933 ? 249 MET   A O   1 
ATOM   322  C CB  . MET   A 1 53  ? 17.55294  -1.82396  -48.42104 1.000 30.23246 ? 249 MET   A CB  1 
ATOM   323  C CG  . MET   A 1 53  ? 17.93998  -2.15085  -49.86043 1.000 33.25235 ? 249 MET   A CG  1 
ATOM   324  S SD  . MET   A 1 53  ? 16.59977  -2.97391  -50.74425 1.000 49.45984 ? 249 MET   A SD  1 
ATOM   325  C CE  . MET   A 1 53  ? 15.23621  -1.83545  -50.46034 1.000 42.09102 ? 249 MET   A CE  1 
ATOM   326  N N   . ALA   A 1 54  ? 17.70235  -2.43524  -45.31212 1.000 31.87618 ? 250 ALA   A N   1 
ATOM   327  C CA  . ALA   A 1 54  ? 17.20836  -2.24571  -43.95132 1.000 32.55667 ? 250 ALA   A CA  1 
ATOM   328  C C   . ALA   A 1 54  ? 18.25615  -1.57529  -43.07097 1.000 31.99946 ? 250 ALA   A C   1 
ATOM   329  O O   . ALA   A 1 54  ? 17.93520  -0.64965  -42.31534 1.000 34.68943 ? 250 ALA   A O   1 
ATOM   330  C CB  . ALA   A 1 54  ? 16.77490  -3.58635  -43.36305 1.000 30.96104 ? 250 ALA   A CB  1 
ATOM   331  N N   . GLU   A 1 55  ? 19.51924  -2.02115  -43.15696 1.000 30.63089 ? 251 GLU   A N   1 
ATOM   332  C CA  . GLU   A 1 55  ? 20.58098  -1.39328  -42.37322 1.000 33.71010 ? 251 GLU   A CA  1 
ATOM   333  C C   . GLU   A 1 55  ? 20.71010  0.09639   -42.66786 1.000 39.77439 ? 251 GLU   A C   1 
ATOM   334  O O   . GLU   A 1 55  ? 20.85847  0.90748   -41.74028 1.000 37.10513 ? 251 GLU   A O   1 
ATOM   335  C CB  . GLU   A 1 55  ? 21.92290  -2.10293  -42.59406 1.000 34.80730 ? 251 GLU   A CB  1 
ATOM   336  C CG  . GLU   A 1 55  ? 21.98574  -3.48337  -41.94555 1.000 38.33352 ? 251 GLU   A CG  1 
ATOM   337  C CD  . GLU   A 1 55  ? 23.15965  -4.33510  -42.40427 1.000 43.21663 ? 251 GLU   A CD  1 
ATOM   338  O OE1 . GLU   A 1 55  ? 23.68233  -4.14628  -43.53493 1.000 39.83131 ? 251 GLU   A OE1 1 
ATOM   339  O OE2 . GLU   A 1 55  ? 23.59182  -5.17127  -41.58715 1.000 38.00383 ? 251 GLU   A OE2 1 
ATOM   340  N N   . LYS   A 1 56  ? 20.65963  0.47883   -43.94484 1.000 33.39408 ? 252 LYS   A N   1 
ATOM   341  C CA  . LYS   A 1 56  ? 20.76169  1.89345   -44.29696 1.000 34.95845 ? 252 LYS   A CA  1 
ATOM   342  C C   . LYS   A 1 56  ? 19.61342  2.69629   -43.70907 1.000 42.03617 ? 252 LYS   A C   1 
ATOM   343  O O   . LYS   A 1 56  ? 19.79945  3.84708   -43.29560 1.000 44.74253 ? 252 LYS   A O   1 
ATOM   344  C CB  . LYS   A 1 56  ? 20.78822  2.05363   -45.81920 1.000 36.94871 ? 252 LYS   A CB  1 
ATOM   345  C CG  . LYS   A 1 56  ? 22.18149  1.91542   -46.41639 1.000 40.29279 ? 252 LYS   A CG  1 
ATOM   346  C CD  . LYS   A 1 56  ? 22.13830  1.93752   -47.93785 1.000 49.00892 ? 252 LYS   A CD  1 
ATOM   347  C CE  . LYS   A 1 56  ? 23.00230  0.81758   -48.50686 1.000 44.27139 ? 252 LYS   A CE  1 
ATOM   348  N NZ  . LYS   A 1 56  ? 22.28899  0.04841   -49.57819 1.000 54.17568 ? 252 LYS   A NZ  1 
ATOM   349  N N   . THR   A 1 57  ? 18.42064  2.10635   -43.65391 1.000 34.54281 ? 253 THR   A N   1 
ATOM   350  C CA  . THR   A 1 57  ? 17.25140  2.82801   -43.16774 1.000 38.90211 ? 253 THR   A CA  1 
ATOM   351  C C   . THR   A 1 57  ? 17.10183  2.75383   -41.65571 1.000 40.45889 ? 253 THR   A C   1 
ATOM   352  O O   . THR   A 1 57  ? 16.78909  3.76538   -41.01623 1.000 44.51743 ? 253 THR   A O   1 
ATOM   353  C CB  . THR   A 1 57  ? 15.98391  2.28428   -43.83161 1.000 40.09805 ? 253 THR   A CB  1 
ATOM   354  O OG1 . THR   A 1 57  ? 16.05781  2.50550   -45.24806 1.000 48.06289 ? 253 THR   A OG1 1 
ATOM   355  C CG2 . THR   A 1 57  ? 14.75740  2.98963   -43.28540 1.000 46.11275 ? 253 THR   A CG2 1 
ATOM   356  N N   . LEU   A 1 58  ? 17.32398  1.58014   -41.06038 1.000 34.06294 ? 254 LEU   A N   1 
ATOM   357  C CA  . LEU   A 1 58  ? 16.93481  1.36021   -39.67330 1.000 38.75271 ? 254 LEU   A CA  1 
ATOM   358  C C   . LEU   A 1 58  ? 18.08773  1.29600   -38.67891 1.000 37.99345 ? 254 LEU   A C   1 
ATOM   359  O O   . LEU   A 1 58  ? 17.84029  1.44643   -37.47830 1.000 38.83991 ? 254 LEU   A O   1 
ATOM   360  C CB  . LEU   A 1 58  ? 16.10034  0.07405   -39.55716 1.000 34.46242 ? 254 LEU   A CB  1 
ATOM   361  C CG  . LEU   A 1 58  ? 14.79745  0.09272   -40.35781 1.000 38.60111 ? 254 LEU   A CG  1 
ATOM   362  C CD1 . LEU   A 1 58  ? 14.10934  -1.26603  -40.35721 1.000 33.10801 ? 254 LEU   A CD1 1 
ATOM   363  C CD2 . LEU   A 1 58  ? 13.85659  1.18341   -39.83800 1.000 37.86904 ? 254 LEU   A CD2 1 
ATOM   364  N N   . VAL   A 1 59  ? 19.32401  1.06399   -39.12255 1.000 35.09840 ? 255 VAL   A N   1 
ATOM   365  C CA  . VAL   A 1 59  ? 20.48571  1.15699   -38.23799 1.000 40.09352 ? 255 VAL   A CA  1 
ATOM   366  C C   . VAL   A 1 59  ? 21.63987  1.80653   -38.99551 1.000 46.37712 ? 255 VAL   A C   1 
ATOM   367  O O   . VAL   A 1 59  ? 22.71636  1.21561   -39.16038 1.000 51.88682 ? 255 VAL   A O   1 
ATOM   368  C CB  . VAL   A 1 59  ? 20.88322  -0.21512  -37.65141 1.000 34.84507 ? 255 VAL   A CB  1 
ATOM   369  C CG1 . VAL   A 1 59  ? 19.84513  -0.68505  -36.67325 1.000 44.41764 ? 255 VAL   A CG1 1 
ATOM   370  C CG2 . VAL   A 1 59  ? 21.01895  -1.25849  -38.73412 1.000 43.72343 ? 255 VAL   A CG2 1 
ATOM   371  N N   . ALA   A 1 60  ? 21.42134  3.04683   -39.43726 1.000 45.45458 ? 256 ALA   A N   1 
ATOM   372  C CA  . ALA   A 1 60  ? 22.35614  3.73401   -40.32580 1.000 48.53374 ? 256 ALA   A CA  1 
ATOM   373  C C   . ALA   A 1 60  ? 23.77118  3.82792   -39.76221 1.000 54.40344 ? 256 ALA   A C   1 
ATOM   374  O O   . ALA   A 1 60  ? 24.71806  3.97463   -40.54296 1.000 60.93386 ? 256 ALA   A O   1 
ATOM   375  C CB  . ALA   A 1 60  ? 21.83114  5.13965   -40.63351 1.000 53.36834 ? 256 ALA   A CB  1 
ATOM   376  N N   . LYS   A 1 61  ? 23.93738  3.73722   -38.43649 1.000 61.02819 ? 257 LYS   A N   1 
ATOM   377  C CA  . LYS   A 1 61  ? 25.25191  3.93059   -37.82070 1.000 61.28341 ? 257 LYS   A CA  1 
ATOM   378  C C   . LYS   A 1 61  ? 26.28391  2.95357   -38.37531 1.000 61.39842 ? 257 LYS   A C   1 
ATOM   379  O O   . LYS   A 1 61  ? 27.41328  3.34318   -38.69545 1.000 65.41548 ? 257 LYS   A O   1 
ATOM   380  C CB  . LYS   A 1 61  ? 25.14821  3.78816   -36.29787 1.000 62.79916 ? 257 LYS   A CB  1 
ATOM   381  C CG  . LYS   A 1 61  ? 25.77726  4.93665   -35.49541 1.000 58.17750 ? 257 LYS   A CG  1 
ATOM   382  C CD  . LYS   A 1 61  ? 27.20316  5.23048   -35.96099 1.000 61.44624 ? 257 LYS   A CD  1 
ATOM   383  C CE  . LYS   A 1 61  ? 27.83846  6.34535   -35.14115 1.000 56.54802 ? 257 LYS   A CE  1 
ATOM   384  N NZ  . LYS   A 1 61  ? 29.09870  6.86904   -35.74544 1.000 57.30110 ? 257 LYS   A NZ  1 
ATOM   385  N N   . LEU   A 1 62  ? 25.91661  1.68015   -38.49410 1.000 62.69142 ? 258 LEU   A N   1 
ATOM   386  C CA  . LEU   A 1 62  ? 26.85017  0.65695   -38.95464 1.000 60.21160 ? 258 LEU   A CA  1 
ATOM   387  C C   . LEU   A 1 62  ? 26.64583  0.31900   -40.43249 1.000 57.86708 ? 258 LEU   A C   1 
ATOM   388  O O   . LEU   A 1 62  ? 26.58889  1.20732   -41.28495 1.000 61.51573 ? 258 LEU   A O   1 
ATOM   389  C CB  . LEU   A 1 62  ? 26.72334  -0.60441  -38.08120 1.000 61.89115 ? 258 LEU   A CB  1 
ATOM   390  C CG  . LEU   A 1 62  ? 25.37815  -1.33458  -37.93037 1.000 49.66873 ? 258 LEU   A CG  1 
ATOM   391  C CD1 . LEU   A 1 62  ? 24.99726  -2.15209  -39.16427 1.000 48.43520 ? 258 LEU   A CD1 1 
ATOM   392  C CD2 . LEU   A 1 62  ? 25.38556  -2.22863  -36.70206 1.000 53.20310 ? 258 LEU   A CD2 1 
ATOM   393  N N   . ASN   A 1 69  ? 30.63363  -2.29590  -42.36651 1.000 65.34343 ? 265 ASN   A N   1 
ATOM   394  C CA  . ASN   A 1 69  ? 31.92315  -2.59813  -42.98047 1.000 64.64016 ? 265 ASN   A CA  1 
ATOM   395  C C   . ASN   A 1 69  ? 32.34724  -4.03843  -42.66663 1.000 63.00094 ? 265 ASN   A C   1 
ATOM   396  O O   . ASN   A 1 69  ? 33.26367  -4.58220  -43.28808 1.000 61.75454 ? 265 ASN   A O   1 
ATOM   397  C CB  . ASN   A 1 69  ? 32.98655  -1.60912  -42.49277 1.000 62.55604 ? 265 ASN   A CB  1 
ATOM   398  C CG  . ASN   A 1 69  ? 34.27767  -1.70272  -43.27831 1.000 71.77854 ? 265 ASN   A CG  1 
ATOM   399  O OD1 . ASN   A 1 69  ? 35.30435  -2.13339  -42.75255 1.000 74.92053 ? 265 ASN   A OD1 1 
ATOM   400  N ND2 . ASN   A 1 69  ? 34.24073  -1.27554  -44.53979 1.000 75.29707 ? 265 ASN   A ND2 1 
ATOM   401  N N   . LYS   A 1 70  ? 31.66427  -4.65025  -41.70141 1.000 57.98369 ? 266 LYS   A N   1 
ATOM   402  C CA  . LYS   A 1 70  ? 31.97683  -5.99597  -41.24780 1.000 48.10744 ? 266 LYS   A CA  1 
ATOM   403  C C   . LYS   A 1 70  ? 31.12187  -7.02145  -41.99418 1.000 39.81373 ? 266 LYS   A C   1 
ATOM   404  O O   . LYS   A 1 70  ? 30.20722  -6.67886  -42.74211 1.000 41.43495 ? 266 LYS   A O   1 
ATOM   405  C CB  . LYS   A 1 70  ? 31.75239  -6.09294  -39.74246 1.000 48.24976 ? 266 LYS   A CB  1 
ATOM   406  C CG  . LYS   A 1 70  ? 32.36914  -4.92328  -39.00245 1.000 58.28696 ? 266 LYS   A CG  1 
ATOM   407  C CD  . LYS   A 1 70  ? 32.31648  -5.08817  -37.50299 1.000 57.05713 ? 266 LYS   A CD  1 
ATOM   408  C CE  . LYS   A 1 70  ? 33.56730  -4.51496  -36.85838 1.000 64.07897 ? 266 LYS   A CE  1 
ATOM   409  N NZ  . LYS   A 1 70  ? 33.44229  -4.50203  -35.37307 1.000 63.11295 ? 266 LYS   A NZ  1 
ATOM   410  N N   . GLU   A 1 71  ? 31.44537  -8.29697  -41.79349 1.000 35.64407 ? 267 GLU   A N   1 
ATOM   411  C CA  . GLU   A 1 71  ? 30.67454  -9.38445  -42.38715 1.000 40.07460 ? 267 GLU   A CA  1 
ATOM   412  C C   . GLU   A 1 71  ? 29.19633  -9.24696  -42.02656 1.000 33.84247 ? 267 GLU   A C   1 
ATOM   413  O O   . GLU   A 1 71  ? 28.85700  -8.80297  -40.93069 1.000 36.73974 ? 267 GLU   A O   1 
ATOM   414  C CB  . GLU   A 1 71  ? 31.21592  -10.71763 -41.87316 1.000 38.58418 ? 267 GLU   A CB  1 
ATOM   415  C CG  . GLU   A 1 71  ? 31.29787  -11.82529 -42.87997 1.000 45.72862 ? 267 GLU   A CG  1 
ATOM   416  C CD  . GLU   A 1 71  ? 31.97896  -13.04772 -42.29239 1.000 46.24912 ? 267 GLU   A CD  1 
ATOM   417  O OE1 . GLU   A 1 71  ? 32.67144  -12.90374 -41.26013 1.000 47.79724 ? 267 GLU   A OE1 1 
ATOM   418  O OE2 . GLU   A 1 71  ? 31.79169  -14.15243 -42.83483 1.000 47.93076 ? 267 GLU   A OE2 1 
ATOM   419  N N   . ALA   A 1 72  ? 28.32069  -9.63837  -42.95414 1.000 34.49356 ? 268 ALA   A N   1 
ATOM   420  C CA  . ALA   A 1 72  ? 26.88457  -9.48383  -42.72476 1.000 32.56028 ? 268 ALA   A CA  1 
ATOM   421  C C   . ALA   A 1 72  ? 26.44687  -10.16990 -41.43586 1.000 33.54689 ? 268 ALA   A C   1 
ATOM   422  O O   . ALA   A 1 72  ? 25.60208  -9.64468  -40.70329 1.000 32.93195 ? 268 ALA   A O   1 
ATOM   423  C CB  . ALA   A 1 72  ? 26.10248  -10.03837 -43.90922 1.000 31.58803 ? 268 ALA   A CB  1 
ATOM   424  N N   . GLU   A 1 73  ? 27.02881  -11.33435 -41.13819 1.000 31.95794 ? 269 GLU   A N   1 
ATOM   425  C CA  . GLU   A 1 73  ? 26.65140  -12.10450 -39.95701 1.000 30.49661 ? 269 GLU   A CA  1 
ATOM   426  C C   . GLU   A 1 73  ? 27.04689  -11.39368 -38.67007 1.000 31.35653 ? 269 GLU   A C   1 
ATOM   427  O O   . GLU   A 1 73  ? 26.32050  -11.45563 -37.67255 1.000 28.50434 ? 269 GLU   A O   1 
ATOM   428  C CB  . GLU   A 1 73  ? 27.29507  -13.48969 -40.01622 1.000 32.00891 ? 269 GLU   A CB  1 
ATOM   429  C CG  . GLU   A 1 73  ? 26.62488  -14.40925 -41.01817 1.000 35.44228 ? 269 GLU   A CG  1 
ATOM   430  C CD  . GLU   A 1 73  ? 27.15866  -14.24053 -42.41942 1.000 34.43143 ? 269 GLU   A CD  1 
ATOM   431  O OE1 . GLU   A 1 73  ? 27.88134  -13.25036 -42.67931 1.000 37.15634 ? 269 GLU   A OE1 1 
ATOM   432  O OE2 . GLU   A 1 73  ? 26.83873  -15.09285 -43.27103 1.000 34.61942 ? 269 GLU   A OE2 1 
ATOM   433  N N   . VAL   A 1 74  ? 28.20310  -10.73292 -38.66975 1.000 29.48311 ? 270 VAL   A N   1 
ATOM   434  C CA  . VAL   A 1 74  ? 28.66128  -10.03636 -37.47712 1.000 31.61112 ? 270 VAL   A CA  1 
ATOM   435  C C   . VAL   A 1 74  ? 27.84174  -8.76569  -37.25601 1.000 28.95547 ? 270 VAL   A C   1 
ATOM   436  O O   . VAL   A 1 74  ? 27.51617  -8.41458  -36.11511 1.000 30.91259 ? 270 VAL   A O   1 
ATOM   437  C CB  . VAL   A 1 74  ? 30.17192  -9.74434  -37.59336 1.000 33.06834 ? 270 VAL   A CB  1 
ATOM   438  C CG1 . VAL   A 1 74  ? 30.65062  -8.86613  -36.43353 1.000 36.89274 ? 270 VAL   A CG1 1 
ATOM   439  C CG2 . VAL   A 1 74  ? 30.97424  -11.04258 -37.67606 1.000 36.14837 ? 270 VAL   A CG2 1 
ATOM   440  N N   . ARG   A 1 75  ? 27.49064  -8.06067  -38.34064 1.000 32.13185 ? 271 ARG   A N   1 
ATOM   441  C CA  . ARG   A 1 75  ? 26.59061  -6.90750  -38.23962 1.000 31.60929 ? 271 ARG   A CA  1 
ATOM   442  C C   . ARG   A 1 75  ? 25.25187  -7.29148  -37.61854 1.000 29.66816 ? 271 ARG   A C   1 
ATOM   443  O O   . ARG   A 1 75  ? 24.72267  -6.55583  -36.78027 1.000 25.61754 ? 271 ARG   A O   1 
ATOM   444  C CB  . ARG   A 1 75  ? 26.34862  -6.28301  -39.61736 1.000 27.55732 ? 271 ARG   A CB  1 
ATOM   445  C CG  . ARG   A 1 75  ? 27.61258  -5.88694  -40.36550 1.000 32.89823 ? 271 ARG   A CG  1 
ATOM   446  C CD  . ARG   A 1 75  ? 27.31084  -4.82675  -41.42925 1.000 34.43041 ? 271 ARG   A CD  1 
ATOM   447  N NE  . ARG   A 1 75  ? 26.33783  -5.26179  -42.42681 1.000 33.77288 ? 271 ARG   A NE  1 
ATOM   448  C CZ  . ARG   A 1 75  ? 26.63872  -5.90328  -43.55149 1.000 41.19297 ? 271 ARG   A CZ  1 
ATOM   449  N NH1 . ARG   A 1 75  ? 27.87052  -6.31454  -43.80752 1.000 36.36654 ? 271 ARG   A NH1 1 
ATOM   450  N NH2 . ARG   A 1 75  ? 25.68593  -6.10966  -44.45703 1.000 33.64174 ? 271 ARG   A NH2 1 
ATOM   451  N N   . ILE   A 1 76  ? 24.67506  -8.42182  -38.04134 1.000 27.01074 ? 272 ILE   A N   1 
ATOM   452  C CA  . ILE   A 1 76  ? 23.41424  -8.87825  -37.44819 1.000 29.27492 ? 272 ILE   A CA  1 
ATOM   453  C C   . ILE   A 1 76  ? 23.62505  -9.21715  -35.97836 1.000 26.91249 ? 272 ILE   A C   1 
ATOM   454  O O   . ILE   A 1 76  ? 22.84824  -8.80889  -35.10190 1.000 27.26255 ? 272 ILE   A O   1 
ATOM   455  C CB  . ILE   A 1 76  ? 22.85411  -10.07634 -38.23551 1.000 24.41246 ? 272 ILE   A CB  1 
ATOM   456  C CG1 . ILE   A 1 76  ? 22.44113  -9.64416  -39.64778 1.000 27.20478 ? 272 ILE   A CG1 1 
ATOM   457  C CG2 . ILE   A 1 76  ? 21.68273  -10.71050 -37.50176 1.000 25.80034 ? 272 ILE   A CG2 1 
ATOM   458  C CD1 . ILE   A 1 76  ? 22.17797  -10.82015 -40.58835 1.000 25.96162 ? 272 ILE   A CD1 1 
ATOM   459  N N   . PHE   A 1 77  ? 24.69294  -9.96604  -35.69526 1.000 24.99801 ? 273 PHE   A N   1 
ATOM   460  C CA  . PHE   A 1 77  ? 25.12145  -10.27676 -34.33014 1.000 29.00822 ? 273 PHE   A CA  1 
ATOM   461  C C   . PHE   A 1 77  ? 25.15788  -9.03251  -33.43829 1.000 30.64980 ? 273 PHE   A C   1 
ATOM   462  O O   . PHE   A 1 77  ? 24.66601  -9.05334  -32.30081 1.000 30.81575 ? 273 PHE   A O   1 
ATOM   463  C CB  . PHE   A 1 77  ? 26.49932  -10.95397 -34.41448 1.000 29.25261 ? 273 PHE   A CB  1 
ATOM   464  C CG  . PHE   A 1 77  ? 27.24942  -11.02163 -33.12759 1.000 31.72012 ? 273 PHE   A CG  1 
ATOM   465  C CD1 . PHE   A 1 77  ? 27.05364  -12.07723 -32.24577 1.000 31.84207 ? 273 PHE   A CD1 1 
ATOM   466  C CD2 . PHE   A 1 77  ? 28.18599  -10.05357 -32.81078 1.000 37.97113 ? 273 PHE   A CD2 1 
ATOM   467  C CE1 . PHE   A 1 77  ? 27.77710  -12.15140 -31.06839 1.000 39.93180 ? 273 PHE   A CE1 1 
ATOM   468  C CE2 . PHE   A 1 77  ? 28.91187  -10.12096 -31.64390 1.000 38.31765 ? 273 PHE   A CE2 1 
ATOM   469  C CZ  . PHE   A 1 77  ? 28.70771  -11.16789 -30.76414 1.000 43.99463 ? 273 PHE   A CZ  1 
ATOM   470  N N   . HIS   A 1 78  ? 25.73476  -7.92550  -33.93329 1.000 27.91884 ? 274 HIS   A N   1 
ATOM   471  C CA  . HIS   A 1 78  ? 25.78193  -6.72193  -33.09747 1.000 37.25119 ? 274 HIS   A CA  1 
ATOM   472  C C   . HIS   A 1 78  ? 24.40565  -6.07358  -32.93622 1.000 27.74691 ? 274 HIS   A C   1 
ATOM   473  O O   . HIS   A 1 78  ? 24.09553  -5.52854  -31.86967 1.000 31.01032 ? 274 HIS   A O   1 
ATOM   474  C CB  . HIS   A 1 78  ? 26.80905  -5.73273  -33.64867 1.000 33.38483 ? 274 HIS   A CB  1 
ATOM   475  C CG  . HIS   A 1 78  ? 28.22329  -6.17043  -33.41507 1.000 42.01997 ? 274 HIS   A CG  1 
ATOM   476  N ND1 . HIS   A 1 78  ? 28.71778  -6.42675  -32.15143 1.000 46.12297 ? 274 HIS   A ND1 1 
ATOM   477  C CD2 . HIS   A 1 78  ? 29.22567  -6.46802  -34.27677 1.000 44.70022 ? 274 HIS   A CD2 1 
ATOM   478  C CE1 . HIS   A 1 78  ? 29.97371  -6.83110  -32.24410 1.000 47.24994 ? 274 HIS   A CE1 1 
ATOM   479  N NE2 . HIS   A 1 78  ? 30.30611  -6.86572  -33.52283 1.000 50.06157 ? 274 HIS   A NE2 1 
ATOM   480  N N   . CYS   A 1 79  ? 23.58037  -6.09213  -33.98188 1.000 28.89011 ? 275 CYS   A N   1 
ATOM   481  C CA  . CYS   A 1 79  ? 22.20567  -5.62410  -33.83460 1.000 25.72696 ? 275 CYS   A CA  1 
ATOM   482  C C   . CYS   A 1 79  ? 21.45418  -6.47082  -32.81319 1.000 28.55139 ? 275 CYS   A C   1 
ATOM   483  O O   . CYS   A 1 79  ? 20.69269  -5.94139  -31.98399 1.000 29.59479 ? 275 CYS   A O   1 
ATOM   484  C CB  . CYS   A 1 79  ? 21.48374  -5.66993  -35.18041 1.000 31.29435 ? 275 CYS   A CB  1 
ATOM   485  S SG  . CYS   A 1 79  ? 22.05392  -4.44378  -36.38366 1.000 32.94865 ? 275 CYS   A SG  1 
ATOM   486  N N   . CYS   A 1 80  ? 21.66526  -7.79097  -32.85456 1.000 21.00514 ? 276 CYS   A N   1 
ATOM   487  C CA  . CYS   A 1 80  ? 20.98865  -8.69291  -31.92344 1.000 29.20415 ? 276 CYS   A CA  1 
ATOM   488  C C   . CYS   A 1 80  ? 21.38556  -8.39215  -30.48116 1.000 29.91889 ? 276 CYS   A C   1 
ATOM   489  O O   . CYS   A 1 80  ? 20.52999  -8.31194  -29.58802 1.000 29.25481 ? 276 CYS   A O   1 
ATOM   490  C CB  . CYS   A 1 80  ? 21.31433  -10.14070 -32.28926 1.000 28.53876 ? 276 CYS   A CB  1 
ATOM   491  S SG  . CYS   A 1 80  ? 20.52573  -10.69738 -33.79426 1.000 27.29592 ? 276 CYS   A SG  1 
ATOM   492  N N   . GLN   A 1 81  ? 22.68863  -8.22977  -30.23704 1.000 26.08307 ? 277 GLN   A N   1 
ATOM   493  C CA  . GLN   A 1 81  ? 23.17117  -7.85786  -28.91028 1.000 29.89747 ? 277 GLN   A CA  1 
ATOM   494  C C   . GLN   A 1 81  ? 22.51454  -6.58205  -28.42144 1.000 27.77686 ? 277 GLN   A C   1 
ATOM   495  O O   . GLN   A 1 81  ? 22.06168  -6.49377  -27.26543 1.000 26.95418 ? 277 GLN   A O   1 
ATOM   496  C CB  . GLN   A 1 81  ? 24.68542  -7.66770  -28.94504 1.000 28.17781 ? 277 GLN   A CB  1 
ATOM   497  C CG  . GLN   A 1 81  ? 25.46842  -8.92885  -28.99854 1.000 29.58254 ? 277 GLN   A CG  1 
ATOM   498  C CD  . GLN   A 1 81  ? 26.87230  -8.68858  -28.51306 1.000 38.97408 ? 277 GLN   A CD  1 
ATOM   499  O OE1 . GLN   A 1 81  ? 27.18300  -8.95694  -27.35815 1.000 35.55900 ? 277 GLN   A OE1 1 
ATOM   500  N NE2 . GLN   A 1 81  ? 27.73117  -8.16760  -29.38959 1.000 42.39213 ? 277 GLN   A NE2 1 
ATOM   501  N N   . CYS   A 1 82  ? 22.46125  -5.57035  -29.28317 1.000 25.88594 ? 278 CYS   A N   1 
ATOM   502  C CA  . CYS   A 1 82  ? 21.86859  -4.30370  -28.87724 1.000 28.21977 ? 278 CYS   A CA  1 
ATOM   503  C C   . CYS   A 1 82  ? 20.40675  -4.48613  -28.49834 1.000 31.22942 ? 278 CYS   A C   1 
ATOM   504  O O   . CYS   A 1 82  ? 19.92405  -3.86195  -27.54871 1.000 30.72758 ? 278 CYS   A O   1 
ATOM   505  C CB  . CYS   A 1 82  ? 22.00661  -3.26472  -29.98750 1.000 34.53291 ? 278 CYS   A CB  1 
ATOM   506  S SG  . CYS   A 1 82  ? 23.67275  -2.59791  -30.15388 1.000 40.81301 ? 278 CYS   A SG  1 
ATOM   507  N N   . THR   A 1 83  ? 19.68462  -5.33498  -29.24022 1.000 26.41994 ? 279 THR   A N   1 
ATOM   508  C CA  . THR   A 1 83  ? 18.29292  -5.61904  -28.91154 1.000 25.52969 ? 279 THR   A CA  1 
ATOM   509  C C   . THR   A 1 83  ? 18.17578  -6.24070  -27.52898 1.000 25.74644 ? 279 THR   A C   1 
ATOM   510  O O   . THR   A 1 83  ? 17.29388  -5.88057  -26.73948 1.000 25.87625 ? 279 THR   A O   1 
ATOM   511  C CB  . THR   A 1 83  ? 17.70255  -6.56726  -29.95906 1.000 26.80060 ? 279 THR   A CB  1 
ATOM   512  O OG1 . THR   A 1 83  ? 17.86837  -5.99099  -31.26703 1.000 31.23456 ? 279 THR   A OG1 1 
ATOM   513  C CG2 . THR   A 1 83  ? 16.23918  -6.80543  -29.68446 1.000 31.29834 ? 279 THR   A CG2 1 
ATOM   514  N N   . SER   A 1 84  ? 19.06337  -7.17730  -27.22339 1.000 24.01079 ? 280 SER   A N   1 
ATOM   515  C CA  . SER   A 1 84  ? 18.99524  -7.88151  -25.95224 1.000 21.82605 ? 280 SER   A CA  1 
ATOM   516  C C   . SER   A 1 84  ? 19.31952  -6.95497  -24.79460 1.000 25.28313 ? 280 SER   A C   1 
ATOM   517  O O   . SER   A 1 84  ? 18.68668  -7.03498  -23.73211 1.000 25.74998 ? 280 SER   A O   1 
ATOM   518  C CB  . SER   A 1 84  ? 19.94272  -9.07680  -25.97970 1.000 26.46673 ? 280 SER   A CB  1 
ATOM   519  O OG  . SER   A 1 84  ? 19.40353  -10.11440 -26.77636 1.000 28.00729 ? 280 SER   A OG  1 
ATOM   520  N N   . VAL   A 1 85  ? 20.29329  -6.06202  -24.98529 1.000 23.21701 ? 281 VAL   A N   1 
ATOM   521  C CA  . VAL   A 1 85  ? 20.62844  -5.09437  -23.94206 1.000 24.98895 ? 281 VAL   A CA  1 
ATOM   522  C C   . VAL   A 1 85  ? 19.41842  -4.22949  -23.60835 1.000 25.94939 ? 281 VAL   A C   1 
ATOM   523  O O   . VAL   A 1 85  ? 19.10465  -3.99952  -22.43672 1.000 23.32416 ? 281 VAL   A O   1 
ATOM   524  C CB  . VAL   A 1 85  ? 21.83819  -4.24569  -24.37291 1.000 24.65676 ? 281 VAL   A CB  1 
ATOM   525  C CG1 . VAL   A 1 85  ? 21.97637  -3.00554  -23.45995 1.000 27.88850 ? 281 VAL   A CG1 1 
ATOM   526  C CG2 . VAL   A 1 85  ? 23.09744  -5.09384  -24.32181 1.000 27.31500 ? 281 VAL   A CG2 1 
ATOM   527  N N   . GLU   A 1 86  ? 18.70054  -3.76025  -24.62434 1.000 25.25937 ? 282 GLU   A N   1 
ATOM   528  C CA  . GLU   A 1 86  ? 17.47586  -3.01394  -24.36329 1.000 29.03661 ? 282 GLU   A CA  1 
ATOM   529  C C   . GLU   A 1 86  ? 16.46088  -3.84288  -23.57193 1.000 32.08862 ? 282 GLU   A C   1 
ATOM   530  O O   . GLU   A 1 86  ? 15.84870  -3.34869  -22.61258 1.000 26.86065 ? 282 GLU   A O   1 
ATOM   531  C CB  . GLU   A 1 86  ? 16.87829  -2.52062  -25.68160 1.000 29.04669 ? 282 GLU   A CB  1 
ATOM   532  C CG  . GLU   A 1 86  ? 17.85012  -1.68512  -26.50378 1.000 37.77526 ? 282 GLU   A CG  1 
ATOM   533  C CD  . GLU   A 1 86  ? 17.79502  -0.20624  -26.14605 1.000 48.37657 ? 282 GLU   A CD  1 
ATOM   534  O OE1 . GLU   A 1 86  ? 17.05974  0.16105   -25.18399 1.000 44.52249 ? 282 GLU   A OE1 1 
ATOM   535  O OE2 . GLU   A 1 86  ? 18.45068  0.59119   -26.86565 1.000 49.14532 ? 282 GLU   A OE2 1 
ATOM   536  N N   . THR   A 1 87  ? 16.26733  -5.11161  -23.95131 1.000 25.06363 ? 283 THR   A N   1 
ATOM   537  C CA  . THR   A 1 87  ? 15.25525  -5.92424  -23.27455 1.000 26.87439 ? 283 THR   A CA  1 
ATOM   538  C C   . THR   A 1 87  ? 15.64010  -6.21300  -21.82547 1.000 23.20394 ? 283 THR   A C   1 
ATOM   539  O O   . THR   A 1 87  ? 14.76565  -6.29145  -20.96091 1.000 25.13199 ? 283 THR   A O   1 
ATOM   540  C CB  . THR   A 1 87  ? 15.01398  -7.22418  -24.06294 1.000 22.67645 ? 283 THR   A CB  1 
ATOM   541  O OG1 . THR   A 1 87  ? 14.65778  -6.88332  -25.40365 1.000 24.36471 ? 283 THR   A OG1 1 
ATOM   542  C CG2 . THR   A 1 87  ? 13.88797  -8.06624  -23.45674 1.000 25.72085 ? 283 THR   A CG2 1 
ATOM   543  N N   . VAL   A 1 88  ? 16.93221  -6.35287  -21.52951 1.000 24.17041 ? 284 VAL   A N   1 
ATOM   544  C CA  . VAL   A 1 88  ? 17.34258  -6.55437  -20.14106 1.000 23.68351 ? 284 VAL   A CA  1 
ATOM   545  C C   . VAL   A 1 88  ? 16.94912  -5.34664  -19.29598 1.000 26.44355 ? 284 VAL   A C   1 
ATOM   546  O O   . VAL   A 1 88  ? 16.51715  -5.48722  -18.14438 1.000 25.15050 ? 284 VAL   A O   1 
ATOM   547  C CB  . VAL   A 1 88  ? 18.85784  -6.83208  -20.06015 1.000 26.23197 ? 284 VAL   A CB  1 
ATOM   548  C CG1 . VAL   A 1 88  ? 19.34171  -6.80700  -18.58797 1.000 25.44886 ? 284 VAL   A CG1 1 
ATOM   549  C CG2 . VAL   A 1 88  ? 19.18641  -8.17443  -20.71484 1.000 23.66738 ? 284 VAL   A CG2 1 
ATOM   550  N N   . THR   A 1 89  ? 17.09932  -4.13951  -19.84792 1.000 24.42823 ? 285 THR   A N   1 
ATOM   551  C CA  . THR   A 1 89  ? 16.68178  -2.94823  -19.11398 1.000 27.78816 ? 285 THR   A CA  1 
ATOM   552  C C   . THR   A 1 89  ? 15.17736  -2.93880  -18.88256 1.000 31.55240 ? 285 THR   A C   1 
ATOM   553  O O   . THR   A 1 89  ? 14.71098  -2.60483  -17.78575 1.000 27.65636 ? 285 THR   A O   1 
ATOM   554  C CB  . THR   A 1 89  ? 17.13498  -1.69976  -19.86844 1.000 31.19482 ? 285 THR   A CB  1 
ATOM   555  O OG1 . THR   A 1 89  ? 18.56460  -1.69398  -19.90746 1.000 41.61277 ? 285 THR   A OG1 1 
ATOM   556  C CG2 . THR   A 1 89  ? 16.64752  -0.44587  -19.17413 1.000 39.99464 ? 285 THR   A CG2 1 
ATOM   557  N N   . GLU   A 1 90  ? 14.39997  -3.34219  -19.88915 1.000 23.37785 ? 286 GLU   A N   1 
ATOM   558  C CA  . GLU   A 1 90  ? 12.95839  -3.44835  -19.70033 1.000 23.42867 ? 286 GLU   A CA  1 
ATOM   559  C C   . GLU   A 1 90  ? 12.62145  -4.49652  -18.64274 1.000 26.09988 ? 286 GLU   A C   1 
ATOM   560  O O   . GLU   A 1 90  ? 11.74990  -4.27385  -17.78930 1.000 25.38329 ? 286 GLU   A O   1 
ATOM   561  C CB  . GLU   A 1 90  ? 12.29287  -3.79169  -21.03703 1.000 27.23918 ? 286 GLU   A CB  1 
ATOM   562  C CG  . GLU   A 1 90  ? 12.21102  -2.60017  -22.00804 1.000 27.06933 ? 286 GLU   A CG  1 
ATOM   563  C CD  . GLU   A 1 90  ? 11.49198  -2.94945  -23.30296 1.000 35.58522 ? 286 GLU   A CD  1 
ATOM   564  O OE1 . GLU   A 1 90  ? 11.29002  -4.15443  -23.57752 1.000 31.84721 ? 286 GLU   A OE1 1 
ATOM   565  O OE2 . GLU   A 1 90  ? 11.10405  -2.01445  -24.03707 1.000 39.62210 ? 286 GLU   A OE2 1 
ATOM   566  N N   . LEU   A 1 91  ? 13.31266  -5.64110  -18.66996 1.000 21.13341 ? 287 LEU   A N   1 
ATOM   567  C CA  . LEU   A 1 91  ? 13.02749  -6.70859  -17.70060 1.000 22.32467 ? 287 LEU   A CA  1 
ATOM   568  C C   . LEU   A 1 91  ? 13.39792  -6.29451  -16.28223 1.000 25.29698 ? 287 LEU   A C   1 
ATOM   569  O O   . LEU   A 1 91  ? 12.75873  -6.71807  -15.31260 1.000 25.14541 ? 287 LEU   A O   1 
ATOM   570  C CB  . LEU   A 1 91  ? 13.80091  -7.98258  -18.06675 1.000 18.68985 ? 287 LEU   A CB  1 
ATOM   571  C CG  . LEU   A 1 91  ? 13.12524  -8.84509  -19.13332 1.000 24.56705 ? 287 LEU   A CG  1 
ATOM   572  C CD1 . LEU   A 1 91  ? 14.15588  -9.76646  -19.77688 1.000 24.24535 ? 287 LEU   A CD1 1 
ATOM   573  C CD2 . LEU   A 1 91  ? 11.95239  -9.63825  -18.52121 1.000 21.77604 ? 287 LEU   A CD2 1 
ATOM   574  N N   . THR   A 1 92  ? 14.46506  -5.51730  -16.14112 1.000 26.17972 ? 288 THR   A N   1 
ATOM   575  C CA  . THR   A 1 92  ? 14.86296  -5.04937  -14.82088 1.000 26.43577 ? 288 THR   A CA  1 
ATOM   576  C C   . THR   A 1 92  ? 13.79400  -4.14594  -14.21788 1.000 27.81042 ? 288 THR   A C   1 
ATOM   577  O O   . THR   A 1 92  ? 13.40455  -4.31209  -13.05657 1.000 30.10732 ? 288 THR   A O   1 
ATOM   578  C CB  . THR   A 1 92  ? 16.20668  -4.33469  -14.91699 1.000 24.24274 ? 288 THR   A CB  1 
ATOM   579  O OG1 . THR   A 1 92  ? 17.20728  -5.27738  -15.33301 1.000 29.48777 ? 288 THR   A OG1 1 
ATOM   580  C CG2 . THR   A 1 92  ? 16.59891  -3.73190  -13.57583 1.000 35.38582 ? 288 THR   A CG2 1 
ATOM   581  N N   . GLU   A 1 93  ? 13.29412  -3.19311  -14.99929 1.000 25.24046 ? 289 GLU   A N   1 
ATOM   582  C CA  . GLU   A 1 93  ? 12.20547  -2.34397  -14.51366 1.000 31.03799 ? 289 GLU   A CA  1 
ATOM   583  C C   . GLU   A 1 93  ? 10.93750  -3.14845  -14.24956 1.000 31.98698 ? 289 GLU   A C   1 
ATOM   584  O O   . GLU   A 1 93  ? 10.23725  -2.89337  -13.26448 1.000 26.21808 ? 289 GLU   A O   1 
ATOM   585  C CB  . GLU   A 1 93  ? 11.94329  -1.21192  -15.51252 1.000 34.99878 ? 289 GLU   A CB  1 
ATOM   586  C CG  . GLU   A 1 93  ? 13.13317  -0.25701  -15.72777 1.000 37.94241 ? 289 GLU   A CG  1 
ATOM   587  C CD  . GLU   A 1 93  ? 13.73195  0.25100   -14.40760 1.000 48.75999 ? 289 GLU   A CD  1 
ATOM   588  O OE1 . GLU   A 1 93  ? 12.98728  0.91257   -13.65429 1.000 47.41566 ? 289 GLU   A OE1 1 
ATOM   589  O OE2 . GLU   A 1 93  ? 14.93479  0.01597   -14.12638 1.000 46.38730 ? 289 GLU   A OE2 1 
ATOM   590  N N   . PHE   A 1 94  ? 10.60962  -4.11947  -15.11675 1.000 25.78569 ? 290 PHE   A N   1 
ATOM   591  C CA  . PHE   A 1 94  ? 9.46128   -4.99067  -14.84348 1.000 23.91349 ? 290 PHE   A CA  1 
ATOM   592  C C   . PHE   A 1 94  ? 9.63513   -5.73142  -13.52242 1.000 24.34220 ? 290 PHE   A C   1 
ATOM   593  O O   . PHE   A 1 94  ? 8.70364   -5.79995  -12.71207 1.000 26.18248 ? 290 PHE   A O   1 
ATOM   594  C CB  . PHE   A 1 94  ? 9.27063   -5.99151  -15.99549 1.000 22.20083 ? 290 PHE   A CB  1 
ATOM   595  C CG  . PHE   A 1 94  ? 8.21606   -7.06460  -15.74409 1.000 19.39641 ? 290 PHE   A CG  1 
ATOM   596  C CD1 . PHE   A 1 94  ? 6.84478   -6.76477  -15.76769 1.000 19.72161 ? 290 PHE   A CD1 1 
ATOM   597  C CD2 . PHE   A 1 94  ? 8.59702   -8.38672  -15.55337 1.000 22.03646 ? 290 PHE   A CD2 1 
ATOM   598  C CE1 . PHE   A 1 94  ? 5.87596   -7.75885  -15.57214 1.000 21.18594 ? 290 PHE   A CE1 1 
ATOM   599  C CE2 . PHE   A 1 94  ? 7.64204   -9.39549  -15.36429 1.000 23.50239 ? 290 PHE   A CE2 1 
ATOM   600  C CZ  . PHE   A 1 94  ? 6.27599   -9.07912  -15.36114 1.000 20.93663 ? 290 PHE   A CZ  1 
ATOM   601  N N   . ALA   A 1 95  ? 10.82207  -6.29701  -13.29602 1.000 26.63029 ? 291 ALA   A N   1 
ATOM   602  C CA  . ALA   A 1 95  ? 11.06256  -7.06405  -12.08002 1.000 23.77778 ? 291 ALA   A CA  1 
ATOM   603  C C   . ALA   A 1 95  ? 10.89560  -6.19296  -10.84158 1.000 26.85035 ? 291 ALA   A C   1 
ATOM   604  O O   . ALA   A 1 95  ? 10.27299  -6.61609  -9.86044  1.000 27.68385 ? 291 ALA   A O   1 
ATOM   605  C CB  . ALA   A 1 95  ? 12.46076  -7.67903  -12.12090 1.000 24.09833 ? 291 ALA   A CB  1 
ATOM   606  N N   . LYS   A 1 96  ? 11.42741  -4.96915  -10.88250 1.000 28.41919 ? 292 LYS   A N   1 
ATOM   607  C CA  . LYS   A 1 96  ? 11.27405  -4.03834  -9.76368  1.000 36.14116 ? 292 LYS   A CA  1 
ATOM   608  C C   . LYS   A 1 96  ? 9.81746   -3.77492  -9.43615  1.000 34.67077 ? 292 LYS   A C   1 
ATOM   609  O O   . LYS   A 1 96  ? 9.49655   -3.43366  -8.29213  1.000 34.20960 ? 292 LYS   A O   1 
ATOM   610  C CB  . LYS   A 1 96  ? 11.96403  -2.71131  -10.07197 1.000 37.89158 ? 292 LYS   A CB  1 
ATOM   611  C CG  . LYS   A 1 96  ? 13.48152  -2.76010  -10.06851 1.000 39.37716 ? 292 LYS   A CG  1 
ATOM   612  C CD  . LYS   A 1 96  ? 14.02540  -1.36578  -9.79924  1.000 47.43410 ? 292 LYS   A CD  1 
ATOM   613  C CE  . LYS   A 1 96  ? 15.11108  -1.00830  -10.79048 1.000 45.37178 ? 292 LYS   A CE  1 
ATOM   614  N NZ  . LYS   A 1 96  ? 15.28693  0.45922   -10.91766 1.000 50.75240 ? 292 LYS   A NZ  1 
ATOM   615  N N   . ALA   A 1 97  ? 8.93132   -3.94578  -10.40557 1.000 34.32677 ? 293 ALA   A N   1 
ATOM   616  C CA  . ALA   A 1 97  ? 7.51252   -3.70423  -10.21900 1.000 29.82953 ? 293 ALA   A CA  1 
ATOM   617  C C   . ALA   A 1 97  ? 6.74483   -4.93926  -9.78052  1.000 31.89466 ? 293 ALA   A C   1 
ATOM   618  O O   . ALA   A 1 97  ? 5.53605   -4.83584  -9.54405  1.000 31.38505 ? 293 ALA   A O   1 
ATOM   619  C CB  . ALA   A 1 97  ? 6.90229   -3.15733  -11.51312 1.000 33.03165 ? 293 ALA   A CB  1 
ATOM   620  N N   . ILE   A 1 98  ? 7.39688   -6.09577  -9.67063  1.000 31.30808 ? 294 ILE   A N   1 
ATOM   621  C CA  . ILE   A 1 98  ? 6.73081   -7.30872  -9.19114  1.000 29.82440 ? 294 ILE   A CA  1 
ATOM   622  C C   . ILE   A 1 98  ? 6.61788   -7.20888  -7.67442  1.000 33.59571 ? 294 ILE   A C   1 
ATOM   623  O O   . ILE   A 1 98  ? 7.64645   -7.06913  -6.99510  1.000 34.00054 ? 294 ILE   A O   1 
ATOM   624  C CB  . ILE   A 1 98  ? 7.48811   -8.58887  -9.58339  1.000 30.31252 ? 294 ILE   A CB  1 
ATOM   625  C CG1 . ILE   A 1 98  ? 7.54810   -8.77058  -11.10836 1.000 23.29167 ? 294 ILE   A CG1 1 
ATOM   626  C CG2 . ILE   A 1 98  ? 6.86385   -9.80177  -8.91084  1.000 30.53538 ? 294 ILE   A CG2 1 
ATOM   627  C CD1 . ILE   A 1 98  ? 8.49751   -9.90728  -11.51564 1.000 27.19810 ? 294 ILE   A CD1 1 
ATOM   628  N N   . PRO   A 1 99  ? 5.40572   -7.28013  -7.10732  1.000 35.98515 ? 295 PRO   A N   1 
ATOM   629  C CA  . PRO   A 1 99  ? 5.25172   -7.13356  -5.65223  1.000 39.08363 ? 295 PRO   A CA  1 
ATOM   630  C C   . PRO   A 1 99  ? 6.15506   -8.07341  -4.87862  1.000 36.69505 ? 295 PRO   A C   1 
ATOM   631  O O   . PRO   A 1 99  ? 6.13713   -9.28958  -5.10073  1.000 36.13816 ? 295 PRO   A O   1 
ATOM   632  C CB  . PRO   A 1 99  ? 3.76749   -7.45008  -5.41386  1.000 39.79921 ? 295 PRO   A CB  1 
ATOM   633  C CG  . PRO   A 1 99  ? 3.09144   -7.16467  -6.70787  1.000 38.66038 ? 295 PRO   A CG  1 
ATOM   634  C CD  . PRO   A 1 99  ? 4.11488   -7.27786  -7.81718  1.000 36.87627 ? 295 PRO   A CD  1 
ATOM   635  N N   . GLY   A 1 100 ? 6.97687   -7.50446  -3.99772  1.000 31.83920 ? 296 GLY   A N   1 
ATOM   636  C CA  . GLY   A 1 100 ? 7.89031   -8.26166  -3.17407  1.000 35.36989 ? 296 GLY   A CA  1 
ATOM   637  C C   . GLY   A 1 100 ? 9.30901   -8.33761  -3.70398  1.000 37.26122 ? 296 GLY   A C   1 
ATOM   638  O O   . GLY   A 1 100 ? 10.23995  -8.54251  -2.91141  1.000 29.99388 ? 296 GLY   A O   1 
ATOM   639  N N   . PHE   A 1 101 ? 9.50320   -8.17784  -5.01991  1.000 30.84169 ? 297 PHE   A N   1 
ATOM   640  C CA  . PHE   A 1 101 ? 10.84955  -8.30470  -5.57784  1.000 28.92590 ? 297 PHE   A CA  1 
ATOM   641  C C   . PHE   A 1 101 ? 11.80327  -7.30338  -4.94743  1.000 27.58972 ? 297 PHE   A C   1 
ATOM   642  O O   . PHE   A 1 101 ? 12.94736  -7.63996  -4.61786  1.000 32.00026 ? 297 PHE   A O   1 
ATOM   643  C CB  . PHE   A 1 101 ? 10.81939  -8.11420  -7.09753  1.000 26.95089 ? 297 PHE   A CB  1 
ATOM   644  C CG  . PHE   A 1 101 ? 12.14695  -8.38185  -7.77023  1.000 27.95360 ? 297 PHE   A CG  1 
ATOM   645  C CD1 . PHE   A 1 101 ? 12.48445  -9.66457  -8.17678  1.000 28.54135 ? 297 PHE   A CD1 1 
ATOM   646  C CD2 . PHE   A 1 101 ? 13.05161  -7.35187  -7.98776  1.000 30.10087 ? 297 PHE   A CD2 1 
ATOM   647  C CE1 . PHE   A 1 101 ? 13.70834  -9.91836  -8.80519  1.000 27.96532 ? 297 PHE   A CE1 1 
ATOM   648  C CE2 . PHE   A 1 101 ? 14.28387  -7.59995  -8.61921  1.000 26.41298 ? 297 PHE   A CE2 1 
ATOM   649  C CZ  . PHE   A 1 101 ? 14.60620  -8.88677  -9.01466  1.000 26.41749 ? 297 PHE   A CZ  1 
ATOM   650  N N   . ALA   A 1 102 ? 11.35590  -6.06138  -4.77645  1.000 29.25875 ? 298 ALA   A N   1 
ATOM   651  C CA  . ALA   A 1 102 ? 12.25781  -5.05303  -4.23981  1.000 38.55449 ? 298 ALA   A CA  1 
ATOM   652  C C   . ALA   A 1 102 ? 12.52120  -5.24070  -2.75175  1.000 35.14641 ? 298 ALA   A C   1 
ATOM   653  O O   . ALA   A 1 102 ? 13.38152  -4.55050  -2.19972  1.000 36.77251 ? 298 ALA   A O   1 
ATOM   654  C CB  . ALA   A 1 102 ? 11.70061  -3.65327  -4.50965  1.000 40.33867 ? 298 ALA   A CB  1 
ATOM   655  N N   . ASN   A 1 103 ? 11.80830  -6.15308  -2.09113  1.000 38.97704 ? 299 ASN   A N   1 
ATOM   656  C CA  . ASN   A 1 103 ? 12.09561  -6.46612  -0.70093  1.000 33.09340 ? 299 ASN   A CA  1 
ATOM   657  C C   . ASN   A 1 103 ? 13.22146  -7.47909  -0.55531  1.000 43.22669 ? 299 ASN   A C   1 
ATOM   658  O O   . ASN   A 1 103 ? 13.69946  -7.70056  0.56371   1.000 39.19225 ? 299 ASN   A O   1 
ATOM   659  C CB  . ASN   A 1 103 ? 10.82068  -6.97795  -0.02159  1.000 40.42917 ? 299 ASN   A CB  1 
ATOM   660  C CG  . ASN   A 1 103 ? 9.71156   -5.95461  -0.04951  1.000 39.10618 ? 299 ASN   A CG  1 
ATOM   661  O OD1 . ASN   A 1 103 ? 8.67189   -6.16564  -0.67334  1.000 43.84344 ? 299 ASN   A OD1 1 
ATOM   662  N ND2 . ASN   A 1 103 ? 9.92715   -4.82809  0.62362   1.000 46.72472 ? 299 ASN   A ND2 1 
ATOM   663  N N   . LEU   A 1 104 ? 13.66928  -8.07891  -1.65440  1.000 32.35092 ? 300 LEU   A N   1 
ATOM   664  C CA  . LEU   A 1 104 ? 14.71011  -9.08885  -1.59597  1.000 33.07121 ? 300 LEU   A CA  1 
ATOM   665  C C   . LEU   A 1 104 ? 16.07356  -8.42961  -1.42147  1.000 32.37032 ? 300 LEU   A C   1 
ATOM   666  O O   . LEU   A 1 104 ? 16.25501  -7.23999  -1.70031  1.000 34.66670 ? 300 LEU   A O   1 
ATOM   667  C CB  . LEU   A 1 104 ? 14.70005  -9.94443  -2.86758  1.000 30.54478 ? 300 LEU   A CB  1 
ATOM   668  C CG  . LEU   A 1 104 ? 13.41698  -10.73675 -3.15793  1.000 30.40723 ? 300 LEU   A CG  1 
ATOM   669  C CD1 . LEU   A 1 104 ? 13.48732  -11.39903 -4.56032  1.000 28.71808 ? 300 LEU   A CD1 1 
ATOM   670  C CD2 . LEU   A 1 104 ? 13.10508  -11.76231 -2.07004  1.000 30.61188 ? 300 LEU   A CD2 1 
ATOM   671  N N   . ASP   A 1 105 ? 17.03002  -9.22132  -0.93119  1.000 34.00602 ? 301 ASP   A N   1 
ATOM   672  C CA  . ASP   A 1 105 ? 18.42235  -8.78908  -0.86470  1.000 40.23928 ? 301 ASP   A CA  1 
ATOM   673  C C   . ASP   A 1 105 ? 18.88504  -8.39302  -2.25669  1.000 40.70862 ? 301 ASP   A C   1 
ATOM   674  O O   . ASP   A 1 105 ? 18.63848  -9.11752  -3.22297  1.000 38.17179 ? 301 ASP   A O   1 
ATOM   675  C CB  . ASP   A 1 105 ? 19.29175  -9.92374  -0.31263  1.000 42.07148 ? 301 ASP   A CB  1 
ATOM   676  C CG  . ASP   A 1 105 ? 20.72241  -9.49041  -0.00682  1.000 52.07899 ? 301 ASP   A CG  1 
ATOM   677  O OD1 . ASP   A 1 105 ? 20.98036  -9.03177  1.13044   1.000 61.92080 ? 301 ASP   A OD1 1 
ATOM   678  O OD2 . ASP   A 1 105 ? 21.59691  -9.63566  -0.89080  1.000 55.91572 ? 301 ASP   A OD2 1 
ATOM   679  N N   . LEU   A 1 106 ? 19.54205  -7.23644  -2.36470  1.000 37.54847 ? 302 LEU   A N   1 
ATOM   680  C CA  . LEU   A 1 106 ? 19.92616  -6.74686  -3.68583  1.000 39.16069 ? 302 LEU   A CA  1 
ATOM   681  C C   . LEU   A 1 106 ? 20.78488  -7.74793  -4.43699  1.000 37.51463 ? 302 LEU   A C   1 
ATOM   682  O O   . LEU   A 1 106 ? 20.65512  -7.87598  -5.65884  1.000 41.36259 ? 302 LEU   A O   1 
ATOM   683  C CB  . LEU   A 1 106 ? 20.65046  -5.41023  -3.57834  1.000 41.79457 ? 302 LEU   A CB  1 
ATOM   684  C CG  . LEU   A 1 106 ? 20.88788  -4.74514  -4.93633  1.000 46.87833 ? 302 LEU   A CG  1 
ATOM   685  C CD1 . LEU   A 1 106 ? 19.59054  -4.15722  -5.46647  1.000 47.44639 ? 302 LEU   A CD1 1 
ATOM   686  C CD2 . LEU   A 1 106 ? 21.92921  -3.65596  -4.79269  1.000 47.11360 ? 302 LEU   A CD2 1 
ATOM   687  N N   . ASN   A 1 107 ? 21.64630  -8.48168  -3.73457  1.000 36.09568 ? 303 ASN   A N   1 
ATOM   688  C CA  . ASN   A 1 107 ? 22.46989  -9.47459  -4.41020  1.000 39.63940 ? 303 ASN   A CA  1 
ATOM   689  C C   . ASN   A 1 107 ? 21.61642  -10.58451 -5.00357  1.000 37.00483 ? 303 ASN   A C   1 
ATOM   690  O O   . ASN   A 1 107 ? 21.95922  -11.13598 -6.05457  1.000 37.65959 ? 303 ASN   A O   1 
ATOM   691  C CB  . ASN   A 1 107 ? 23.48984  -10.06332 -3.43276  1.000 50.80028 ? 303 ASN   A CB  1 
ATOM   692  C CG  . ASN   A 1 107 ? 24.63475  -9.11299  -3.14438  1.000 52.76383 ? 303 ASN   A CG  1 
ATOM   693  O OD1 . ASN   A 1 107 ? 25.17125  -8.47351  -4.05048  1.000 49.66796 ? 303 ASN   A OD1 1 
ATOM   694  N ND2 . ASN   A 1 107 ? 25.00493  -9.00637  -1.87687  1.000 49.71346 ? 303 ASN   A ND2 1 
ATOM   695  N N   . ASP   A 1 108 ? 20.51875  -10.93948 -4.32587  1.000 35.47846 ? 304 ASP   A N   1 
ATOM   696  C CA  . ASP   A 1 108 ? 19.60305  -11.95084 -4.84093  1.000 34.79815 ? 304 ASP   A CA  1 
ATOM   697  C C   . ASP   A 1 108 ? 18.79712  -11.42002 -6.01885  1.000 34.81979 ? 304 ASP   A C   1 
ATOM   698  O O   . ASP   A 1 108 ? 18.47928  -12.18035 -6.94215  1.000 36.15162 ? 304 ASP   A O   1 
ATOM   699  C CB  . ASP   A 1 108 ? 18.65930  -12.42549 -3.73883  1.000 34.55949 ? 304 ASP   A CB  1 
ATOM   700  C CG  . ASP   A 1 108 ? 19.29413  -13.46344 -2.82637  1.000 43.78848 ? 304 ASP   A CG  1 
ATOM   701  O OD1 . ASP   A 1 108 ? 20.42010  -13.92598 -3.11867  1.000 42.74439 ? 304 ASP   A OD1 1 
ATOM   702  O OD2 . ASP   A 1 108 ? 18.65162  -13.81560 -1.81805  1.000 42.72416 ? 304 ASP   A OD2 1 
ATOM   703  N N   . GLN   A 1 109 ? 18.44061  -10.13486 -5.99689  1.000 30.43441 ? 305 GLN   A N   1 
ATOM   704  C CA  . GLN   A 1 109 ? 17.81049  -9.53308  -7.16772  1.000 32.40476 ? 305 GLN   A CA  1 
ATOM   705  C C   . GLN   A 1 109 ? 18.70905  -9.66410  -8.39540  1.000 32.83994 ? 305 GLN   A C   1 
ATOM   706  O O   . GLN   A 1 109 ? 18.24566  -10.03008 -9.48409  1.000 29.74096 ? 305 GLN   A O   1 
ATOM   707  C CB  . GLN   A 1 109 ? 17.48234  -8.06862  -6.89765  1.000 29.42461 ? 305 GLN   A CB  1 
ATOM   708  C CG  . GLN   A 1 109 ? 16.52111  -7.82647  -5.75248  1.000 30.58309 ? 305 GLN   A CG  1 
ATOM   709  C CD  . GLN   A 1 109 ? 16.21096  -6.35294  -5.58076  1.000 34.34156 ? 305 GLN   A CD  1 
ATOM   710  O OE1 . GLN   A 1 109 ? 16.23444  -5.58703  -6.54873  1.000 39.50209 ? 305 GLN   A OE1 1 
ATOM   711  N NE2 . GLN   A 1 109 ? 15.93436  -5.93860  -4.34145  1.000 36.45891 ? 305 GLN   A NE2 1 
ATOM   712  N N   . VAL   A 1 110 ? 20.00449  -9.37246  -8.23357  1.000 31.09686 ? 306 VAL   A N   1 
ATOM   713  C CA  . VAL   A 1 110 ? 20.95576  -9.52749  -9.33648  1.000 32.13908 ? 306 VAL   A CA  1 
ATOM   714  C C   . VAL   A 1 110 ? 20.96939  -10.96939 -9.83325  1.000 32.10298 ? 306 VAL   A C   1 
ATOM   715  O O   . VAL   A 1 110 ? 20.88389  -11.23570 -11.03682 1.000 28.90711 ? 306 VAL   A O   1 
ATOM   716  C CB  . VAL   A 1 110 ? 22.36327  -9.07488  -8.90459  1.000 33.86976 ? 306 VAL   A CB  1 
ATOM   717  C CG1 . VAL   A 1 110 ? 23.39269  -9.44596  -9.97292  1.000 34.55918 ? 306 VAL   A CG1 1 
ATOM   718  C CG2 . VAL   A 1 110 ? 22.38284  -7.57172  -8.61328  1.000 36.58011 ? 306 VAL   A CG2 1 
ATOM   719  N N   . THR   A 1 111 ? 21.08960  -11.91828 -8.91094  1.000 30.00996 ? 307 THR   A N   1 
ATOM   720  C CA  . THR   A 1 111 ? 21.12175  -13.32669 -9.28313  1.000 31.54062 ? 307 THR   A CA  1 
ATOM   721  C C   . THR   A 1 111 ? 19.84602  -13.74903 -10.01729 1.000 31.01891 ? 307 THR   A C   1 
ATOM   722  O O   . THR   A 1 111 ? 19.90697  -14.48099 -11.01116 1.000 27.83727 ? 307 THR   A O   1 
ATOM   723  C CB  . THR   A 1 111 ? 21.34290  -14.16564 -8.02400  1.000 36.26568 ? 307 THR   A CB  1 
ATOM   724  O OG1 . THR   A 1 111 ? 22.63381  -13.83955 -7.48013  1.000 38.59741 ? 307 THR   A OG1 1 
ATOM   725  C CG2 . THR   A 1 111 ? 21.27703  -15.64334 -8.34264  1.000 32.59247 ? 307 THR   A CG2 1 
ATOM   726  N N   . LEU   A 1 112 ? 18.68387  -13.27965 -9.55571  1.000 28.48231 ? 308 LEU   A N   1 
ATOM   727  C CA  . LEU   A 1 112 ? 17.43027  -13.63077 -10.22325 1.000 28.74348 ? 308 LEU   A CA  1 
ATOM   728  C C   . LEU   A 1 112 ? 17.39900  -13.09180 -11.64527 1.000 27.85131 ? 308 LEU   A C   1 
ATOM   729  O O   . LEU   A 1 112 ? 16.97709  -13.78999 -12.57744 1.000 24.33096 ? 308 LEU   A O   1 
ATOM   730  C CB  . LEU   A 1 112 ? 16.25172  -13.08673 -9.42607  1.000 23.33844 ? 308 LEU   A CB  1 
ATOM   731  C CG  . LEU   A 1 112 ? 16.05896  -13.81657 -8.09642  1.000 25.26891 ? 308 LEU   A CG  1 
ATOM   732  C CD1 . LEU   A 1 112 ? 14.81617  -13.30739 -7.40307  1.000 28.07356 ? 308 LEU   A CD1 1 
ATOM   733  C CD2 . LEU   A 1 112 ? 15.97110  -15.31281 -8.32159  1.000 26.58621 ? 308 LEU   A CD2 1 
ATOM   734  N N   . LEU   A 1 113 ? 17.88062  -11.86325 -11.83435 1.000 25.75312 ? 309 LEU   A N   1 
ATOM   735  C CA  . LEU   A 1 113 ? 17.87067  -11.26790 -13.16154 1.000 29.08588 ? 309 LEU   A CA  1 
ATOM   736  C C   . LEU   A 1 113 ? 18.90916  -11.94201 -14.05035 1.000 28.93270 ? 309 LEU   A C   1 
ATOM   737  O O   . LEU   A 1 113 ? 18.64146  -12.22307 -15.22570 1.000 25.99556 ? 309 LEU   A O   1 
ATOM   738  C CB  . LEU   A 1 113 ? 18.13691  -9.77460  -13.03220 1.000 28.07832 ? 309 LEU   A CB  1 
ATOM   739  C CG  . LEU   A 1 113 ? 16.86548  -8.94540  -12.79250 1.000 30.78611 ? 309 LEU   A CG  1 
ATOM   740  C CD1 . LEU   A 1 113 ? 17.26003  -7.53267  -12.38330 1.000 38.94370 ? 309 LEU   A CD1 1 
ATOM   741  C CD2 . LEU   A 1 113 ? 15.94117  -8.90933  -14.00273 1.000 29.19814 ? 309 LEU   A CD2 1 
ATOM   742  N N   . LYS   A 1 114 ? 20.09616  -12.21887 -13.49717 1.000 27.97976 ? 310 LYS   A N   1 
ATOM   743  C CA  . LYS   A 1 114 ? 21.16532  -12.86520 -14.26005 1.000 29.76418 ? 310 LYS   A CA  1 
ATOM   744  C C   . LYS   A 1 114 ? 20.69631  -14.16317 -14.91659 1.000 28.19607 ? 310 LYS   A C   1 
ATOM   745  O O   . LYS   A 1 114 ? 20.91523  -14.38788 -16.11417 1.000 30.58558 ? 310 LYS   A O   1 
ATOM   746  C CB  . LYS   A 1 114 ? 22.35352  -13.14165 -13.33740 1.000 27.74675 ? 310 LYS   A CB  1 
ATOM   747  C CG  . LYS   A 1 114 ? 23.48623  -13.91938 -13.98392 1.000 31.79611 ? 310 LYS   A CG  1 
ATOM   748  C CD  . LYS   A 1 114 ? 24.47004  -14.36778 -12.93130 1.000 30.86300 ? 310 LYS   A CD  1 
ATOM   749  C CE  . LYS   A 1 114 ? 25.64862  -15.08340 -13.57376 1.000 35.29647 ? 310 LYS   A CE  1 
ATOM   750  N NZ  . LYS   A 1 114 ? 26.48550  -14.08102 -14.29459 1.000 35.12001 ? 310 LYS   A NZ  1 
ATOM   751  N N   . TYR   A 1 115 ? 20.04469  -15.03439 -14.14449 1.000 28.50269 ? 311 TYR   A N   1 
ATOM   752  C CA  . TYR   A 1 115 ? 19.60680  -16.32294 -14.66523 1.000 30.31304 ? 311 TYR   A CA  1 
ATOM   753  C C   . TYR   A 1 115 ? 18.23921  -16.27246 -15.32539 1.000 31.37161 ? 311 TYR   A C   1 
ATOM   754  O O   . TYR   A 1 115 ? 17.92845  -17.15215 -16.14063 1.000 28.84865 ? 311 TYR   A O   1 
ATOM   755  C CB  . TYR   A 1 115 ? 19.60286  -17.36230 -13.54144 1.000 30.72656 ? 311 TYR   A CB  1 
ATOM   756  C CG  . TYR   A 1 115 ? 21.00028  -17.76280 -13.16436 1.000 35.81285 ? 311 TYR   A CG  1 
ATOM   757  C CD1 . TYR   A 1 115 ? 21.67490  -18.72841 -13.88782 1.000 37.35732 ? 311 TYR   A CD1 1 
ATOM   758  C CD2 . TYR   A 1 115 ? 21.66652  -17.14106 -12.11716 1.000 34.27834 ? 311 TYR   A CD2 1 
ATOM   759  C CE1 . TYR   A 1 115 ? 22.96258  -19.08667 -13.56741 1.000 39.29722 ? 311 TYR   A CE1 1 
ATOM   760  C CE2 . TYR   A 1 115 ? 22.96388  -17.49410 -11.79369 1.000 41.27124 ? 311 TYR   A CE2 1 
ATOM   761  C CZ  . TYR   A 1 115 ? 23.60283  -18.46918 -12.52482 1.000 42.70957 ? 311 TYR   A CZ  1 
ATOM   762  O OH  . TYR   A 1 115 ? 24.89153  -18.83570 -12.21534 1.000 46.62473 ? 311 TYR   A OH  1 
ATOM   763  N N   . GLY   A 1 116 ? 17.43236  -15.26252 -15.01772 1.000 21.81895 ? 312 GLY   A N   1 
ATOM   764  C CA  . GLY   A 1 116 ? 16.08876  -15.19245 -15.55911 1.000 24.26961 ? 312 GLY   A CA  1 
ATOM   765  C C   . GLY   A 1 116 ? 15.92763  -14.49833 -16.90256 1.000 24.42936 ? 312 GLY   A C   1 
ATOM   766  O O   . GLY   A 1 116 ? 15.01822  -14.86260 -17.66597 1.000 22.55273 ? 312 GLY   A O   1 
ATOM   767  N N   . VAL   A 1 117 ? 16.78571  -13.51820 -17.22570 1.000 22.22181 ? 313 VAL   A N   1 
ATOM   768  C CA  . VAL   A 1 117 ? 16.45955  -12.60945 -18.33563 1.000 22.63850 ? 313 VAL   A CA  1 
ATOM   769  C C   . VAL   A 1 117 ? 16.37380  -13.35163 -19.66191 1.000 22.77089 ? 313 VAL   A C   1 
ATOM   770  O O   . VAL   A 1 117 ? 15.49977  -13.05065 -20.48798 1.000 22.82295 ? 313 VAL   A O   1 
ATOM   771  C CB  . VAL   A 1 117 ? 17.43744  -11.42032 -18.43192 1.000 24.77126 ? 313 VAL   A CB  1 
ATOM   772  C CG1 . VAL   A 1 117 ? 17.13637  -10.40179 -17.35277 1.000 26.10696 ? 313 VAL   A CG1 1 
ATOM   773  C CG2 . VAL   A 1 117 ? 18.90820  -11.86526 -18.42902 1.000 29.34919 ? 313 VAL   A CG2 1 
ATOM   774  N N   . TYR   A 1 118 ? 17.29365  -14.29324 -19.92314 1.000 21.20214 ? 314 TYR   A N   1 
ATOM   775  C CA  . TYR   A 1 118 ? 17.26429  -14.91408 -21.24519 1.000 22.74009 ? 314 TYR   A CA  1 
ATOM   776  C C   . TYR   A 1 118 ? 16.13966  -15.93214 -21.38301 1.000 20.67400 ? 314 TYR   A C   1 
ATOM   777  O O   . TYR   A 1 118 ? 15.61409  -16.11973 -22.48949 1.000 22.38174 ? 314 TYR   A O   1 
ATOM   778  C CB  . TYR   A 1 118 ? 18.61474  -15.54121 -21.57888 1.000 26.41425 ? 314 TYR   A CB  1 
ATOM   779  C CG  . TYR   A 1 118 ? 19.49732  -14.54263 -22.27311 1.000 23.92467 ? 314 TYR   A CG  1 
ATOM   780  C CD1 . TYR   A 1 118 ? 19.21863  -14.13412 -23.57729 1.000 26.94792 ? 314 TYR   A CD1 1 
ATOM   781  C CD2 . TYR   A 1 118 ? 20.57050  -13.94990 -21.60894 1.000 26.87144 ? 314 TYR   A CD2 1 
ATOM   782  C CE1 . TYR   A 1 118 ? 20.01123  -13.19505 -24.21640 1.000 23.73493 ? 314 TYR   A CE1 1 
ATOM   783  C CE2 . TYR   A 1 118 ? 21.38385  -13.00886 -22.25360 1.000 29.67443 ? 314 TYR   A CE2 1 
ATOM   784  C CZ  . TYR   A 1 118 ? 21.09179  -12.63600 -23.54836 1.000 29.28494 ? 314 TYR   A CZ  1 
ATOM   785  O OH  . TYR   A 1 118 ? 21.87129  -11.70118 -24.21258 1.000 29.07007 ? 314 TYR   A OH  1 
ATOM   786  N N   . GLU   A 1 119 ? 15.73904  -16.59478 -20.29769 1.000 19.70187 ? 315 GLU   A N   1 
ATOM   787  C CA  . GLU   A 1 119 ? 14.52278  -17.39064 -20.38765 1.000 22.44910 ? 315 GLU   A CA  1 
ATOM   788  C C   . GLU   A 1 119 ? 13.33016  -16.48513 -20.69574 1.000 22.32553 ? 315 GLU   A C   1 
ATOM   789  O O   . GLU   A 1 119 ? 12.50320  -16.79997 -21.56212 1.000 19.97947 ? 315 GLU   A O   1 
ATOM   790  C CB  . GLU   A 1 119 ? 14.28997  -18.18283 -19.08987 1.000 20.04601 ? 315 GLU   A CB  1 
ATOM   791  C CG  . GLU   A 1 119 ? 15.38204  -19.22645 -18.75385 1.000 21.87100 ? 315 GLU   A CG  1 
ATOM   792  C CD  . GLU   A 1 119 ? 15.18158  -19.81536 -17.36314 1.000 29.09183 ? 315 GLU   A CD  1 
ATOM   793  O OE1 . GLU   A 1 119 ? 16.05781  -20.56172 -16.88496 1.000 27.49917 ? 315 GLU   A OE1 1 
ATOM   794  O OE2 . GLU   A 1 119 ? 14.10909  -19.55770 -16.75871 1.000 26.93632 ? 315 GLU   A OE2 1 
ATOM   795  N N   . ALA   A 1 120 ? 13.27415  -15.31233 -20.04582 1.000 19.73337 ? 316 ALA   A N   1 
ATOM   796  C CA  . ALA   A 1 120 ? 12.22519  -14.33486 -20.33651 1.000 20.46210 ? 316 ALA   A CA  1 
ATOM   797  C C   . ALA   A 1 120 ? 12.33305  -13.80419 -21.75767 1.000 20.14451 ? 316 ALA   A C   1 
ATOM   798  O O   . ALA   A 1 120 ? 11.31307  -13.63473 -22.42419 1.000 21.90782 ? 316 ALA   A O   1 
ATOM   799  C CB  . ALA   A 1 120 ? 12.27732  -13.16469 -19.34598 1.000 19.11038 ? 316 ALA   A CB  1 
ATOM   800  N N   . ILE   A 1 121 ? 13.54919  -13.51375 -22.22788 1.000 19.15209 ? 317 ILE   A N   1 
ATOM   801  C CA  . ILE   A 1 121 ? 13.71255  -12.95692 -23.57108 1.000 20.71014 ? 317 ILE   A CA  1 
ATOM   802  C C   . ILE   A 1 121 ? 13.16679  -13.92316 -24.62157 1.000 17.75052 ? 317 ILE   A C   1 
ATOM   803  O O   . ILE   A 1 121 ? 12.45327  -13.51834 -25.54318 1.000 21.31567 ? 317 ILE   A O   1 
ATOM   804  C CB  . ILE   A 1 121 ? 15.18640  -12.59117 -23.83986 1.000 20.10653 ? 317 ILE   A CB  1 
ATOM   805  C CG1 . ILE   A 1 121 ? 15.53899  -11.28200 -23.13207 1.000 24.84021 ? 317 ILE   A CG1 1 
ATOM   806  C CG2 . ILE   A 1 121 ? 15.45626  -12.40941 -25.36191 1.000 22.49797 ? 317 ILE   A CG2 1 
ATOM   807  C CD1 . ILE   A 1 121 ? 17.03435  -10.90888 -23.22489 1.000 24.64247 ? 317 ILE   A CD1 1 
ATOM   808  N N   . PHE   A 1 122 ? 13.49621  -15.20724 -24.50938 1.000 20.60416 ? 318 PHE   A N   1 
ATOM   809  C CA  . PHE   A 1 122 ? 13.09045  -16.12879 -25.57365 1.000 19.71531 ? 318 PHE   A CA  1 
ATOM   810  C C   . PHE   A 1 122 ? 11.61385  -16.48765 -25.46668 1.000 21.56517 ? 318 PHE   A C   1 
ATOM   811  O O   . PHE   A 1 122 ? 10.96375  -16.73949 -26.48299 1.000 21.33191 ? 318 PHE   A O   1 
ATOM   812  C CB  . PHE   A 1 122 ? 13.98382  -17.37772 -25.55458 1.000 19.57889 ? 318 PHE   A CB  1 
ATOM   813  C CG  . PHE   A 1 122 ? 15.39798  -17.08515 -25.92867 1.000 21.66797 ? 318 PHE   A CG  1 
ATOM   814  C CD1 . PHE   A 1 122 ? 16.44904  -17.55044 -25.16258 1.000 27.21472 ? 318 PHE   A CD1 1 
ATOM   815  C CD2 . PHE   A 1 122 ? 15.67341  -16.33974 -27.06129 1.000 28.49966 ? 318 PHE   A CD2 1 
ATOM   816  C CE1 . PHE   A 1 122 ? 17.76691  -17.27389 -25.52489 1.000 22.27799 ? 318 PHE   A CE1 1 
ATOM   817  C CE2 . PHE   A 1 122 ? 16.99622  -16.05938 -27.43618 1.000 32.67297 ? 318 PHE   A CE2 1 
ATOM   818  C CZ  . PHE   A 1 122 ? 18.03334  -16.51589 -26.64229 1.000 28.36799 ? 318 PHE   A CZ  1 
ATOM   819  N N   . ALA   A 1 123 ? 11.05615  -16.47892 -24.25274 1.000 18.48832 ? 319 ALA   A N   1 
ATOM   820  C CA  . ALA   A 1 123 ? 9.61273   -16.61502 -24.10607 1.000 16.47475 ? 319 ALA   A CA  1 
ATOM   821  C C   . ALA   A 1 123 ? 8.87200   -15.46873 -24.79366 1.000 19.56006 ? 319 ALA   A C   1 
ATOM   822  O O   . ALA   A 1 123 ? 7.92780   -15.70031 -25.55470 1.000 24.54990 ? 319 ALA   A O   1 
ATOM   823  C CB  . ALA   A 1 123 ? 9.24974   -16.68251 -22.61636 1.000 16.17196 ? 319 ALA   A CB  1 
ATOM   824  N N   . MET   A 1 124 ? 9.28449   -14.22145 -24.53368 1.000 15.00859 ? 320 MET   A N   1 
ATOM   825  C CA  . MET   A 1 124 ? 8.62239   -13.05917 -25.13031 1.000 19.37576 ? 320 MET   A CA  1 
ATOM   826  C C   . MET   A 1 124 ? 8.92061   -12.91669 -26.62247 1.000 20.28485 ? 320 MET   A C   1 
ATOM   827  O O   . MET   A 1 124 ? 8.08239   -12.38833 -27.35516 1.000 18.98164 ? 320 MET   A O   1 
ATOM   828  C CB  . MET   A 1 124 ? 9.02990   -11.77867 -24.40271 1.000 20.36545 ? 320 MET   A CB  1 
ATOM   829  C CG  . MET   A 1 124 ? 8.99239   -11.86685 -22.87315 1.000 26.45711 ? 320 MET   A CG  1 
ATOM   830  S SD  . MET   A 1 124 ? 8.80914   -10.23148 -22.10331 1.000 26.42771 ? 320 MET   A SD  1 
ATOM   831  C CE  . MET   A 1 124 ? 10.53810  -9.84799  -21.94746 1.000 31.03473 ? 320 MET   A CE  1 
ATOM   832  N N   . LEU   A 1 125 ? 10.10188  -13.33479 -27.09536 1.000 19.48258 ? 321 LEU   A N   1 
ATOM   833  C CA  . LEU   A 1 125 ? 10.32388  -13.24488 -28.54197 1.000 19.77335 ? 321 LEU   A CA  1 
ATOM   834  C C   . LEU   A 1 125 ? 9.29591   -14.05805 -29.32204 1.000 20.21457 ? 321 LEU   A C   1 
ATOM   835  O O   . LEU   A 1 125 ? 9.01491   -13.75367 -30.48885 1.000 20.70151 ? 321 LEU   A O   1 
ATOM   836  C CB  . LEU   A 1 125 ? 11.72302  -13.71484 -28.93083 1.000 25.48209 ? 321 LEU   A CB  1 
ATOM   837  C CG  . LEU   A 1 125 ? 12.79808  -12.64250 -28.95375 1.000 30.76372 ? 321 LEU   A CG  1 
ATOM   838  C CD1 . LEU   A 1 125 ? 14.15353  -13.31690 -29.20840 1.000 30.30699 ? 321 LEU   A CD1 1 
ATOM   839  C CD2 . LEU   A 1 125 ? 12.49740  -11.57444 -29.97790 1.000 33.82628 ? 321 LEU   A CD2 1 
ATOM   840  N N   . SER   A 1 126 ? 8.75384   -15.11013 -28.71332 1.000 20.68758 ? 322 SER   A N   1 
ATOM   841  C CA  . SER   A 1 126 ? 7.74771   -15.91705 -29.39731 1.000 21.65180 ? 322 SER   A CA  1 
ATOM   842  C C   . SER   A 1 126 ? 6.57959   -15.06546 -29.86269 1.000 19.47658 ? 322 SER   A C   1 
ATOM   843  O O   . SER   A 1 126 ? 5.97436   -15.36234 -30.89761 1.000 21.49268 ? 322 SER   A O   1 
ATOM   844  C CB  . SER   A 1 126 ? 7.25477   -17.03762 -28.47559 1.000 21.97779 ? 322 SER   A CB  1 
ATOM   845  O OG  . SER   A 1 126 ? 8.34457   -17.82427 -28.03802 1.000 25.76128 ? 322 SER   A OG  1 
ATOM   846  N N   . SER   A 1 127 ? 6.25044   -14.00577 -29.11420 1.000 19.26750 ? 323 SER   A N   1 
ATOM   847  C CA  . SER   A 1 127 ? 5.15265   -13.12488 -29.49711 1.000 19.38180 ? 323 SER   A CA  1 
ATOM   848  C C   . SER   A 1 127 ? 5.37328   -12.45180 -30.84616 1.000 22.17796 ? 323 SER   A C   1 
ATOM   849  O O   . SER   A 1 127 ? 4.40496   -11.98886 -31.44875 1.000 24.86147 ? 323 SER   A O   1 
ATOM   850  C CB  . SER   A 1 127 ? 4.95085   -12.04192 -28.43451 1.000 24.74052 ? 323 SER   A CB  1 
ATOM   851  O OG  . SER   A 1 127 ? 4.59816   -12.63235 -27.18172 1.000 23.25080 ? 323 SER   A OG  1 
ATOM   852  N N   . VAL   A 1 128 ? 6.61721   -12.31683 -31.30901 1.000 20.53232 ? 324 VAL   A N   1 
ATOM   853  C CA  . VAL   A 1 128 ? 6.86365   -11.60742 -32.56117 1.000 20.03748 ? 324 VAL   A CA  1 
ATOM   854  C C   . VAL   A 1 128 ? 7.27424   -12.55382 -33.67423 1.000 24.80227 ? 324 VAL   A C   1 
ATOM   855  O O   . VAL   A 1 128 ? 7.71825   -12.10032 -34.73962 1.000 23.83611 ? 324 VAL   A O   1 
ATOM   856  C CB  . VAL   A 1 128 ? 7.90991   -10.48777 -32.40482 1.000 23.31808 ? 324 VAL   A CB  1 
ATOM   857  C CG1 . VAL   A 1 128 ? 7.45021   -9.45090  -31.38951 1.000 27.23919 ? 324 VAL   A CG1 1 
ATOM   858  C CG2 . VAL   A 1 128 ? 9.30450   -11.05184 -32.05255 1.000 24.76312 ? 324 VAL   A CG2 1 
ATOM   859  N N   . MET   A 1 129 ? 7.17993   -13.85117 -33.43831 1.000 23.11715 ? 325 MET   A N   1 
ATOM   860  C CA  . MET   A 1 129 ? 7.63404   -14.87922 -34.35542 1.000 25.23579 ? 325 MET   A CA  1 
ATOM   861  C C   . MET   A 1 129 ? 6.44280   -15.57729 -34.99204 1.000 28.36243 ? 325 MET   A C   1 
ATOM   862  O O   . MET   A 1 129 ? 5.44485   -15.86371 -34.32215 1.000 23.69208 ? 325 MET   A O   1 
ATOM   863  C CB  . MET   A 1 129 ? 8.50021   -15.88322 -33.59006 1.000 23.37739 ? 325 MET   A CB  1 
ATOM   864  C CG  . MET   A 1 129 ? 9.82173   -15.30180 -33.08958 1.000 23.89816 ? 325 MET   A CG  1 
ATOM   865  S SD  . MET   A 1 129 ? 10.70347  -16.62856 -32.23862 1.000 28.96015 ? 325 MET   A SD  1 
ATOM   866  C CE  . MET   A 1 129 ? 12.37912  -16.37560 -32.81903 1.000 31.11131 ? 325 MET   A CE  1 
ATOM   867  N N   . ASN   A 1 130 ? 6.54233   -15.84501 -36.29613 1.000 23.42396 ? 326 ASN   A N   1 
ATOM   868  C CA  . ASN   A 1 130 ? 5.62326   -16.81986 -36.88111 1.000 26.02989 ? 326 ASN   A CA  1 
ATOM   869  C C   . ASN   A 1 130 ? 6.43272   -17.83131 -37.69124 1.000 27.92246 ? 326 ASN   A C   1 
ATOM   870  O O   . ASN   A 1 130 ? 7.66496   -17.81646 -37.63037 1.000 25.34049 ? 326 ASN   A O   1 
ATOM   871  C CB  . ASN   A 1 130 ? 4.52590   -16.13195 -37.70840 1.000 26.80678 ? 326 ASN   A CB  1 
ATOM   872  C CG  . ASN   A 1 130 ? 5.05356   -15.38362 -38.93605 1.000 30.77040 ? 326 ASN   A CG  1 
ATOM   873  O OD1 . ASN   A 1 130 ? 6.05808   -15.75541 -39.54129 1.000 30.53283 ? 326 ASN   A OD1 1 
ATOM   874  N ND2 . ASN   A 1 130 ? 4.34925   -14.32773 -39.31612 1.000 32.69262 ? 326 ASN   A ND2 1 
ATOM   875  N N   . LYS   A 1 131 ? 5.76213   -18.72841 -38.42109 1.000 28.52938 ? 327 LYS   A N   1 
ATOM   876  C CA  . LYS   A 1 131 ? 6.47764   -19.78726 -39.12854 1.000 31.54806 ? 327 LYS   A CA  1 
ATOM   877  C C   . LYS   A 1 131 ? 7.40232   -19.24988 -40.21195 1.000 30.98331 ? 327 LYS   A C   1 
ATOM   878  O O   . LYS   A 1 131 ? 8.34835   -19.94762 -40.60147 1.000 30.14519 ? 327 LYS   A O   1 
ATOM   879  C CB  . LYS   A 1 131 ? 5.47315   -20.79445 -39.71714 1.000 33.39581 ? 327 LYS   A CB  1 
ATOM   880  C CG  . LYS   A 1 131 ? 4.80470   -20.33921 -41.01707 1.000 41.97240 ? 327 LYS   A CG  1 
ATOM   881  C CD  . LYS   A 1 131 ? 4.04960   -21.47459 -41.73666 1.000 51.45243 ? 327 LYS   A CD  1 
ATOM   882  C CE  . LYS   A 1 131 ? 4.18566   -21.37848 -43.27145 1.000 44.37366 ? 327 LYS   A CE  1 
ATOM   883  N NZ  . LYS   A 1 131 ? 5.35164   -22.11732 -43.87258 1.000 45.72873 ? 327 LYS   A NZ  1 
ATOM   884  N N   . ASP   A 1 132 ? 7.18176   -18.02667 -40.67971 1.000 30.39394 ? 328 ASP   A N   1 
ATOM   885  C CA  . ASP   A 1 132 ? 7.97405   -17.47397 -41.77951 1.000 31.91893 ? 328 ASP   A CA  1 
ATOM   886  C C   . ASP   A 1 132 ? 9.10178   -16.54288 -41.33285 1.000 31.46559 ? 328 ASP   A C   1 
ATOM   887  O O   . ASP   A 1 132 ? 10.04849  -16.32297 -42.09899 1.000 28.86009 ? 328 ASP   A O   1 
ATOM   888  C CB  . ASP   A 1 132 ? 7.06356   -16.71766 -42.74922 1.000 33.18156 ? 328 ASP   A CB  1 
ATOM   889  C CG  . ASP   A 1 132 ? 6.05739   -17.63222 -43.43778 1.000 42.01141 ? 328 ASP   A CG  1 
ATOM   890  O OD1 . ASP   A 1 132 ? 6.35209   -18.83854 -43.59136 1.000 42.66864 ? 328 ASP   A OD1 1 
ATOM   891  O OD2 . ASP   A 1 132 ? 4.97726   -17.14094 -43.81744 1.000 47.34672 ? 328 ASP   A OD2 1 
ATOM   892  N N   . GLY   A 1 133 ? 9.04168   -15.99286 -40.12571 1.000 24.16376 ? 329 GLY   A N   1 
ATOM   893  C CA  . GLY   A 1 133 ? 10.08617  -15.08623 -39.70084 1.000 20.72046 ? 329 GLY   A CA  1 
ATOM   894  C C   . GLY   A 1 133 ? 9.67111   -14.37597 -38.42604 1.000 25.46907 ? 329 GLY   A C   1 
ATOM   895  O O   . GLY   A 1 133 ? 8.81615   -14.86167 -37.68905 1.000 23.24123 ? 329 GLY   A O   1 
ATOM   896  N N   . MET   A 1 134 ? 10.26480  -13.21003 -38.20004 1.000 22.21578 ? 330 MET   A N   1 
ATOM   897  C CA  . MET   A 1 134 ? 10.05532  -12.49999 -36.93509 1.000 24.44657 ? 330 MET   A CA  1 
ATOM   898  C C   . MET   A 1 134 ? 10.21842  -10.99727 -37.09539 1.000 25.35323 ? 330 MET   A C   1 
ATOM   899  O O   . MET   A 1 134 ? 11.01297  -10.51725 -37.91399 1.000 23.69112 ? 330 MET   A O   1 
ATOM   900  C CB  . MET   A 1 134 ? 11.00742  -13.09662 -35.90032 1.000 22.58208 ? 330 MET   A CB  1 
ATOM   901  C CG  . MET   A 1 134 ? 12.43935  -12.52141 -35.96379 1.000 26.13092 ? 330 MET   A CG  1 
ATOM   902  S SD  . MET   A 1 134 ? 13.53049  -13.35295 -34.78245 1.000 27.79327 ? 330 MET   A SD  1 
ATOM   903  C CE  . MET   A 1 134 ? 13.22543  -12.35199 -33.33310 1.000 24.17698 ? 330 MET   A CE  1 
ATOM   904  N N   . LEU   A 1 135 ? 9.44412   -10.24983 -36.30182 1.000 24.33427 ? 331 LEU   A N   1 
ATOM   905  C CA  . LEU   A 1 135 ? 9.60280   -8.80463  -36.25174 1.000 24.61174 ? 331 LEU   A CA  1 
ATOM   906  C C   . LEU   A 1 135 ? 10.93174  -8.43079  -35.60776 1.000 22.66624 ? 331 LEU   A C   1 
ATOM   907  O O   . LEU   A 1 135 ? 11.38267  -9.06493  -34.64506 1.000 23.55000 ? 331 LEU   A O   1 
ATOM   908  C CB  . LEU   A 1 135 ? 8.45832   -8.15639  -35.46078 1.000 22.00594 ? 331 LEU   A CB  1 
ATOM   909  C CG  . LEU   A 1 135 ? 7.05840   -8.23492  -36.05723 1.000 23.98379 ? 331 LEU   A CG  1 
ATOM   910  C CD1 . LEU   A 1 135 ? 6.02651   -7.60285  -35.08058 1.000 24.39055 ? 331 LEU   A CD1 1 
ATOM   911  C CD2 . LEU   A 1 135 ? 7.01995   -7.53403  -37.42042 1.000 28.59801 ? 331 LEU   A CD2 1 
ATOM   912  N N   . VAL   A 1 136 ? 11.56060  -7.39084  -36.14301 1.000 20.09779 ? 332 VAL   A N   1 
ATOM   913  C CA  . VAL   A 1 136 ? 12.79314  -6.85202  -35.58508 1.000 21.02547 ? 332 VAL   A CA  1 
ATOM   914  C C   . VAL   A 1 136 ? 12.71500  -5.33111  -35.59534 1.000 25.54996 ? 332 VAL   A C   1 
ATOM   915  O O   . VAL   A 1 136 ? 11.80018  -4.73369  -36.16654 1.000 26.31641 ? 332 VAL   A O   1 
ATOM   916  C CB  . VAL   A 1 136 ? 14.05393  -7.35599  -36.34092 1.000 24.61314 ? 332 VAL   A CB  1 
ATOM   917  C CG1 . VAL   A 1 136 ? 14.12386  -8.87766  -36.30026 1.000 23.70892 ? 332 VAL   A CG1 1 
ATOM   918  C CG2 . VAL   A 1 136 ? 14.08804  -6.85378  -37.77445 1.000 22.86065 ? 332 VAL   A CG2 1 
ATOM   919  N N   . ALA   A 1 137 ? 13.67634  -4.70491  -34.91592 1.000 24.97223 ? 333 ALA   A N   1 
ATOM   920  C CA  . ALA   A 1 137 ? 13.84217  -3.25240  -34.92685 1.000 24.35847 ? 333 ALA   A CA  1 
ATOM   921  C C   . ALA   A 1 137 ? 12.54645  -2.53213  -34.54738 1.000 26.26339 ? 333 ALA   A C   1 
ATOM   922  O O   . ALA   A 1 137 ? 12.02215  -1.70003  -35.28789 1.000 23.62400 ? 333 ALA   A O   1 
ATOM   923  C CB  . ALA   A 1 137 ? 14.35155  -2.77777  -36.29921 1.000 26.66398 ? 333 ALA   A CB  1 
ATOM   924  N N   . TYR   A 1 138 ? 12.02987  -2.86611  -33.36207 1.000 27.00811 ? 334 TYR   A N   1 
ATOM   925  C CA  . TYR   A 1 138 ? 10.85906  -2.17862  -32.80327 1.000 26.08293 ? 334 TYR   A CA  1 
ATOM   926  C C   . TYR   A 1 138 ? 9.65951   -2.23003  -33.75001 1.000 26.05157 ? 334 TYR   A C   1 
ATOM   927  O O   . TYR   A 1 138 ? 8.92375   -1.25357  -33.91122 1.000 25.54546 ? 334 TYR   A O   1 
ATOM   928  C CB  . TYR   A 1 138 ? 11.21849  -0.73733  -32.42274 1.000 28.68125 ? 334 TYR   A CB  1 
ATOM   929  C CG  . TYR   A 1 138 ? 12.25443  -0.71303  -31.31455 1.000 29.87717 ? 334 TYR   A CG  1 
ATOM   930  C CD1 . TYR   A 1 138 ? 11.86952  -0.71256  -29.96721 1.000 31.97669 ? 334 TYR   A CD1 1 
ATOM   931  C CD2 . TYR   A 1 138 ? 13.60830  -0.72761  -31.60085 1.000 28.07916 ? 334 TYR   A CD2 1 
ATOM   932  C CE1 . TYR   A 1 138 ? 12.80466  -0.71100  -28.95686 1.000 32.70509 ? 334 TYR   A CE1 1 
ATOM   933  C CE2 . TYR   A 1 138 ? 14.56007  -0.73522  -30.57636 1.000 34.77207 ? 334 TYR   A CE2 1 
ATOM   934  C CZ  . TYR   A 1 138 ? 14.15267  -0.72397  -29.26818 1.000 27.80909 ? 334 TYR   A CZ  1 
ATOM   935  O OH  . TYR   A 1 138 ? 15.08200  -0.72403  -28.25135 1.000 38.46688 ? 334 TYR   A OH  1 
ATOM   936  N N   . GLY   A 1 139 ? 9.46996   -3.37868  -34.39554 1.000 24.40500 ? 335 GLY   A N   1 
ATOM   937  C CA  . GLY   A 1 139 ? 8.32211   -3.60451  -35.24310 1.000 27.52210 ? 335 GLY   A CA  1 
ATOM   938  C C   . GLY   A 1 139 ? 8.46085   -3.10958  -36.66894 1.000 28.74491 ? 335 GLY   A C   1 
ATOM   939  O O   . GLY   A 1 139 ? 7.52909   -3.29915  -37.46591 1.000 30.42452 ? 335 GLY   A O   1 
ATOM   940  N N   . ASN   A 1 140 ? 9.59097   -2.49844  -37.02182 1.000 25.61363 ? 336 ASN   A N   1 
ATOM   941  C CA  . ASN   A 1 140 ? 9.75121   -1.85656  -38.32257 1.000 28.53646 ? 336 ASN   A CA  1 
ATOM   942  C C   . ASN   A 1 140 ? 10.36260  -2.77253  -39.37230 1.000 30.23921 ? 336 ASN   A C   1 
ATOM   943  O O   . ASN   A 1 140 ? 10.38325  -2.40322  -40.55254 1.000 29.89741 ? 336 ASN   A O   1 
ATOM   944  C CB  . ASN   A 1 140 ? 10.61726  -0.60132  -38.18476 1.000 26.21545 ? 336 ASN   A CB  1 
ATOM   945  C CG  . ASN   A 1 140 ? 9.96285   0.43431   -37.31941 1.000 32.45054 ? 336 ASN   A CG  1 
ATOM   946  O OD1 . ASN   A 1 140 ? 10.44808  0.73609   -36.22446 1.000 29.00947 ? 336 ASN   A OD1 1 
ATOM   947  N ND2 . ASN   A 1 140 ? 8.81716   0.95052   -37.77487 1.000 27.83764 ? 336 ASN   A ND2 1 
ATOM   948  N N   . GLY   A 1 141 ? 10.86439  -3.94418  -38.97399 1.000 27.16964 ? 337 GLY   A N   1 
ATOM   949  C CA  . GLY   A 1 141 ? 11.40354  -4.89819  -39.91840 1.000 27.24445 ? 337 GLY   A CA  1 
ATOM   950  C C   . GLY   A 1 141 ? 10.87699  -6.29264  -39.64136 1.000 31.08130 ? 337 GLY   A C   1 
ATOM   951  O O   . GLY   A 1 141 ? 10.34075  -6.57926  -38.57421 1.000 24.29639 ? 337 GLY   A O   1 
ATOM   952  N N   . PHE   A 1 142 ? 11.02345  -7.16161  -40.64053 1.000 23.21009 ? 338 PHE   A N   1 
ATOM   953  C CA  . PHE   A 1 142 ? 10.62406  -8.56313  -40.51867 1.000 24.08885 ? 338 PHE   A CA  1 
ATOM   954  C C   . PHE   A 1 142 ? 11.70128  -9.38332  -41.20837 1.000 28.22066 ? 338 PHE   A C   1 
ATOM   955  O O   . PHE   A 1 142 ? 11.87996  -9.26398  -42.42221 1.000 27.05089 ? 338 PHE   A O   1 
ATOM   956  C CB  . PHE   A 1 142 ? 9.24375   -8.80225  -41.13314 1.000 23.93518 ? 338 PHE   A CB  1 
ATOM   957  C CG  . PHE   A 1 142 ? 8.75935   -10.22565 -41.05071 1.000 27.33273 ? 338 PHE   A CG  1 
ATOM   958  C CD1 . PHE   A 1 142 ? 8.03376   -10.66883 -39.94679 1.000 23.89964 ? 338 PHE   A CD1 1 
ATOM   959  C CD2 . PHE   A 1 142 ? 9.02388   -11.12339 -42.07632 1.000 25.40107 ? 338 PHE   A CD2 1 
ATOM   960  C CE1 . PHE   A 1 142 ? 7.57150   -11.97953 -39.86532 1.000 28.88204 ? 338 PHE   A CE1 1 
ATOM   961  C CE2 . PHE   A 1 142 ? 8.58669   -12.44695 -42.00191 1.000 25.48602 ? 338 PHE   A CE2 1 
ATOM   962  C CZ  . PHE   A 1 142 ? 7.83555   -12.86991 -40.89076 1.000 29.66640 ? 338 PHE   A CZ  1 
ATOM   963  N N   . ILE   A 1 143 ? 12.43543  -10.17548 -40.44178 1.000 25.24992 ? 339 ILE   A N   1 
ATOM   964  C CA  . ILE   A 1 143 ? 13.51658  -10.99635 -40.97667 1.000 23.96597 ? 339 ILE   A CA  1 
ATOM   965  C C   . ILE   A 1 143 ? 12.99508  -12.41492 -41.15574 1.000 30.71175 ? 339 ILE   A C   1 
ATOM   966  O O   . ILE   A 1 143 ? 12.34681  -12.97420 -40.26152 1.000 23.65091 ? 339 ILE   A O   1 
ATOM   967  C CB  . ILE   A 1 143 ? 14.76427  -10.93529 -40.07684 1.000 24.44816 ? 339 ILE   A CB  1 
ATOM   968  C CG1 . ILE   A 1 143 ? 15.99260  -11.49636 -40.79567 1.000 21.70496 ? 339 ILE   A CG1 1 
ATOM   969  C CG2 . ILE   A 1 143 ? 14.57785  -11.65518 -38.73247 1.000 24.93378 ? 339 ILE   A CG2 1 
ATOM   970  C CD1 . ILE   A 1 143 ? 17.28159  -10.90876 -40.22070 1.000 21.66276 ? 339 ILE   A CD1 1 
ATOM   971  N N   . THR   A 1 144 ? 13.21404  -12.98639 -42.34079 1.000 25.36313 ? 340 THR   A N   1 
ATOM   972  C CA  . THR   A 1 144 ? 12.64792  -14.30275 -42.58432 1.000 27.02187 ? 340 THR   A CA  1 
ATOM   973  C C   . THR   A 1 144 ? 13.49232  -15.39172 -41.94048 1.000 26.51446 ? 340 THR   A C   1 
ATOM   974  O O   . THR   A 1 144 ? 14.72397  -15.28292 -41.79407 1.000 26.05264 ? 340 THR   A O   1 
ATOM   975  C CB  . THR   A 1 144 ? 12.50085  -14.59970 -44.08871 1.000 27.38693 ? 340 THR   A CB  1 
ATOM   976  O OG1 . THR   A 1 144 ? 13.80173  -14.77016 -44.65713 1.000 28.55452 ? 340 THR   A OG1 1 
ATOM   977  C CG2 . THR   A 1 144 ? 11.76871  -13.47746 -44.80766 1.000 27.22521 ? 340 THR   A CG2 1 
ATOM   978  N N   . ARG   A 1 145 ? 12.79451  -16.45716 -41.54902 1.000 25.36410 ? 341 ARG   A N   1 
ATOM   979  C CA  . ARG   A 1 145 ? 13.43724  -17.62197 -40.97189 1.000 20.59186 ? 341 ARG   A CA  1 
ATOM   980  C C   . ARG   A 1 145 ? 14.38576  -18.28125 -41.97109 1.000 32.56188 ? 341 ARG   A C   1 
ATOM   981  O O   . ARG   A 1 145 ? 15.44584  -18.79586 -41.58687 1.000 29.53701 ? 341 ARG   A O   1 
ATOM   982  C CB  . ARG   A 1 145 ? 12.34266  -18.58458 -40.50690 1.000 26.60694 ? 341 ARG   A CB  1 
ATOM   983  C CG  . ARG   A 1 145 ? 12.79674  -19.85467 -39.86667 1.000 27.23898 ? 341 ARG   A CG  1 
ATOM   984  C CD  . ARG   A 1 145 ? 11.55263  -20.62086 -39.44978 1.000 29.95063 ? 341 ARG   A CD  1 
ATOM   985  N NE  . ARG   A 1 145 ? 11.85996  -21.81819 -38.68693 1.000 34.01544 ? 341 ARG   A NE  1 
ATOM   986  C CZ  . ARG   A 1 145 ? 10.92828  -22.59932 -38.16780 1.000 33.64552 ? 341 ARG   A CZ  1 
ATOM   987  N NH1 . ARG   A 1 145 ? 9.64201   -22.34912 -38.35676 1.000 30.56113 ? 341 ARG   A NH1 1 
ATOM   988  N NH2 . ARG   A 1 145 ? 11.29453  -23.67165 -37.47633 1.000 37.87089 ? 341 ARG   A NH2 1 
ATOM   989  N N   . GLU   A 1 146 ? 14.04584  -18.24170 -43.25684 1.000 28.50829 ? 342 GLU   A N   1 
ATOM   990  C CA  . GLU   A 1 146 ? 14.92602  -18.85599 -44.25300 1.000 30.00832 ? 342 GLU   A CA  1 
ATOM   991  C C   . GLU   A 1 146 ? 16.21123  -18.05477 -44.42431 1.000 32.16486 ? 342 GLU   A C   1 
ATOM   992  O O   . GLU   A 1 146 ? 17.29861  -18.63481 -44.56387 1.000 31.72241 ? 342 GLU   A O   1 
ATOM   993  C CB  . GLU   A 1 146 ? 14.19543  -18.99244 -45.58648 1.000 36.13732 ? 342 GLU   A CB  1 
ATOM   994  C CG  . GLU   A 1 146 ? 13.19600  -20.15142 -45.61401 1.000 42.28772 ? 342 GLU   A CG  1 
ATOM   995  C CD  . GLU   A 1 146 ? 13.85245  -21.50229 -45.32259 1.000 49.76622 ? 342 GLU   A CD  1 
ATOM   996  O OE1 . GLU   A 1 146 ? 14.97940  -21.74811 -45.81932 1.000 49.81756 ? 342 GLU   A OE1 1 
ATOM   997  O OE2 . GLU   A 1 146 ? 13.24352  -22.31423 -44.58408 1.000 50.29793 ? 342 GLU   A OE2 1 
ATOM   998  N N   . PHE   A 1 147 ? 16.11337  -16.72072 -44.42450 1.000 28.96335 ? 343 PHE   A N   1 
ATOM   999  C CA  . PHE   A 1 147 ? 17.32346  -15.91332 -44.53976 1.000 27.81490 ? 343 PHE   A CA  1 
ATOM   1000 C C   . PHE   A 1 147 ? 18.28951  -16.22128 -43.40500 1.000 30.44690 ? 343 PHE   A C   1 
ATOM   1001 O O   . PHE   A 1 147 ? 19.48529  -16.43073 -43.63843 1.000 28.96407 ? 343 PHE   A O   1 
ATOM   1002 C CB  . PHE   A 1 147 ? 16.98135  -14.42479 -44.56926 1.000 29.23461 ? 343 PHE   A CB  1 
ATOM   1003 C CG  . PHE   A 1 147 ? 18.19191  -13.53663 -44.59713 1.000 27.18231 ? 343 PHE   A CG  1 
ATOM   1004 C CD1 . PHE   A 1 147 ? 19.03989  -13.54461 -45.70770 1.000 29.26480 ? 343 PHE   A CD1 1 
ATOM   1005 C CD2 . PHE   A 1 147 ? 18.49588  -12.70628 -43.53190 1.000 25.77816 ? 343 PHE   A CD2 1 
ATOM   1006 C CE1 . PHE   A 1 147 ? 20.15791  -12.73991 -45.75228 1.000 27.56426 ? 343 PHE   A CE1 1 
ATOM   1007 C CE2 . PHE   A 1 147 ? 19.62018  -11.88686 -43.56134 1.000 28.65460 ? 343 PHE   A CE2 1 
ATOM   1008 C CZ  . PHE   A 1 147 ? 20.46088  -11.90324 -44.68853 1.000 30.02776 ? 343 PHE   A CZ  1 
ATOM   1009 N N   . LEU   A 1 148 ? 17.78443  -16.26431 -42.15606 1.000 27.30782 ? 344 LEU   A N   1 
ATOM   1010 C CA  . LEU   A 1 148 ? 18.63877  -16.61667 -41.02766 1.000 29.17042 ? 344 LEU   A CA  1 
ATOM   1011 C C   . LEU   A 1 148 ? 19.27128  -17.99210 -41.21882 1.000 25.07129 ? 344 LEU   A C   1 
ATOM   1012 O O   . LEU   A 1 148 ? 20.43580  -18.20389 -40.86288 1.000 29.83067 ? 344 LEU   A O   1 
ATOM   1013 C CB  . LEU   A 1 148 ? 17.83383  -16.56528 -39.71597 1.000 27.42622 ? 344 LEU   A CB  1 
ATOM   1014 C CG  . LEU   A 1 148 ? 17.36548  -15.15688 -39.32218 1.000 23.25994 ? 344 LEU   A CG  1 
ATOM   1015 C CD1 . LEU   A 1 148 ? 16.34281  -15.20007 -38.14510 1.000 26.97731 ? 344 LEU   A CD1 1 
ATOM   1016 C CD2 . LEU   A 1 148 ? 18.56955  -14.27153 -38.95927 1.000 26.17336 ? 344 LEU   A CD2 1 
ATOM   1017 N N   . LYS   A 1 149 ? 18.51207  -18.95089 -41.75154 1.000 29.55813 ? 345 LYS   A N   1 
ATOM   1018 C CA  . LYS   A 1 149 ? 19.08777  -20.26686 -42.01976 1.000 30.56368 ? 345 LYS   A CA  1 
ATOM   1019 C C   . LYS   A 1 149 ? 20.16950  -20.21480 -43.08743 1.000 29.59737 ? 345 LYS   A C   1 
ATOM   1020 O O   . LYS   A 1 149 ? 21.01010  -21.12181 -43.14451 1.000 32.86224 ? 345 LYS   A O   1 
ATOM   1021 C CB  . LYS   A 1 149 ? 18.00074  -21.24878 -42.46217 1.000 31.09788 ? 345 LYS   A CB  1 
ATOM   1022 C CG  . LYS   A 1 149 ? 17.24807  -21.92662 -41.32607 1.000 39.32777 ? 345 LYS   A CG  1 
ATOM   1023 C CD  . LYS   A 1 149 ? 15.96624  -22.55155 -41.84075 1.000 42.16773 ? 345 LYS   A CD  1 
ATOM   1024 C CE  . LYS   A 1 149 ? 16.15767  -24.01371 -42.19539 1.000 49.62123 ? 345 LYS   A CE  1 
ATOM   1025 N NZ  . LYS   A 1 149 ? 14.98038  -24.51025 -42.95889 1.000 45.95416 ? 345 LYS   A NZ  1 
ATOM   1026 N N   . SER   A 1 150 ? 20.16526  -19.18109 -43.92243 1.000 30.43106 ? 346 SER   A N   1 
ATOM   1027 C CA  . SER   A 1 150 ? 21.05498  -19.09201 -45.07883 1.000 31.22394 ? 346 SER   A CA  1 
ATOM   1028 C C   . SER   A 1 150 ? 22.41169  -18.50579 -44.74056 1.000 39.13613 ? 346 SER   A C   1 
ATOM   1029 O O   . SER   A 1 150 ? 23.29377  -18.48406 -45.60950 1.000 33.35840 ? 346 SER   A O   1 
ATOM   1030 C CB  . SER   A 1 150 ? 20.40547  -18.24394 -46.16952 1.000 30.22050 ? 346 SER   A CB  1 
ATOM   1031 O OG  . SER   A 1 150 ? 20.61868  -16.86191 -45.92303 1.000 30.27287 ? 346 SER   A OG  1 
ATOM   1032 N N   . LEU   A 1 151 ? 22.58690  -18.01489 -43.51426 1.000 29.01502 ? 347 LEU   A N   1 
ATOM   1033 C CA  . LEU   A 1 151 ? 23.83634  -17.42363 -43.08368 1.000 33.25326 ? 347 LEU   A CA  1 
ATOM   1034 C C   . LEU   A 1 151 ? 24.88616  -18.50427 -42.88614 1.000 33.52239 ? 347 LEU   A C   1 
ATOM   1035 O O   . LEU   A 1 151 ? 24.57689  -19.69107 -42.75259 1.000 35.17552 ? 347 LEU   A O   1 
ATOM   1036 C CB  . LEU   A 1 151 ? 23.63765  -16.64794 -41.77632 1.000 34.05780 ? 347 LEU   A CB  1 
ATOM   1037 C CG  . LEU   A 1 151 ? 22.54276  -15.58063 -41.79448 1.000 27.68788 ? 347 LEU   A CG  1 
ATOM   1038 C CD1 . LEU   A 1 151 ? 22.43356  -14.93683 -40.40168 1.000 30.20929 ? 347 LEU   A CD1 1 
ATOM   1039 C CD2 . LEU   A 1 151 ? 22.81877  -14.52857 -42.85706 1.000 35.62718 ? 347 LEU   A CD2 1 
ATOM   1040 N N   . ARG   A 1 152 ? 26.14308  -18.07881 -42.84839 1.000 32.72300 ? 348 ARG   A N   1 
ATOM   1041 C CA  . ARG   A 1 152 ? 27.22758  -19.01537 -42.60575 1.000 37.48019 ? 348 ARG   A CA  1 
ATOM   1042 C C   . ARG   A 1 152 ? 27.22715  -19.48961 -41.15865 1.000 37.96268 ? 348 ARG   A C   1 
ATOM   1043 O O   . ARG   A 1 152 ? 26.84724  -18.75734 -40.23509 1.000 36.82870 ? 348 ARG   A O   1 
ATOM   1044 C CB  . ARG   A 1 152 ? 28.58166  -18.38264 -42.95703 1.000 33.28969 ? 348 ARG   A CB  1 
ATOM   1045 C CG  . ARG   A 1 152 ? 29.23033  -17.54103 -41.86595 1.000 37.16491 ? 348 ARG   A CG  1 
ATOM   1046 C CD  . ARG   A 1 152 ? 30.74657  -17.41626 -42.08910 1.000 39.01151 ? 348 ARG   A CD  1 
ATOM   1047 N NE  . ARG   A 1 152 ? 31.34601  -16.32614 -41.32245 1.000 36.87542 ? 348 ARG   A NE  1 
ATOM   1048 C CZ  . ARG   A 1 152 ? 31.75256  -16.42601 -40.06241 1.000 35.74741 ? 348 ARG   A CZ  1 
ATOM   1049 N NH1 . ARG   A 1 152 ? 31.62141  -17.55144 -39.37701 1.000 37.93433 ? 348 ARG   A NH1 1 
ATOM   1050 N NH2 . ARG   A 1 152 ? 32.30797  -15.37128 -39.47405 1.000 39.87443 ? 348 ARG   A NH2 1 
ATOM   1051 N N   . LYS   A 1 153 ? 27.64183  -20.74289 -40.97608 1.000 37.27282 ? 349 LYS   A N   1 
ATOM   1052 C CA  . LYS   A 1 153 ? 27.89855  -21.27479 -39.64732 1.000 35.91791 ? 349 LYS   A CA  1 
ATOM   1053 C C   . LYS   A 1 153 ? 28.85198  -20.33850 -38.90840 1.000 41.53514 ? 349 LYS   A C   1 
ATOM   1054 O O   . LYS   A 1 153 ? 29.76933  -19.78588 -39.52522 1.000 37.14521 ? 349 LYS   A O   1 
ATOM   1055 C CB  . LYS   A 1 153 ? 28.52508  -22.66994 -39.74694 1.000 39.20276 ? 349 LYS   A CB  1 
ATOM   1056 C CG  . LYS   A 1 153 ? 27.78315  -23.81784 -39.09299 1.000 46.54224 ? 349 LYS   A CG  1 
ATOM   1057 C CD  . LYS   A 1 153 ? 26.61243  -24.31288 -39.93071 1.000 51.33391 ? 349 LYS   A CD  1 
ATOM   1058 C CE  . LYS   A 1 153 ? 26.01474  -25.59704 -39.33087 1.000 56.83248 ? 349 LYS   A CE  1 
ATOM   1059 N NZ  . LYS   A 1 153 ? 24.55864  -25.77558 -39.65767 1.000 48.88962 ? 349 LYS   A NZ  1 
ATOM   1060 N N   . PRO   A 1 154 ? 28.68047  -20.13419 -37.59743 1.000 34.59585 ? 350 PRO   A N   1 
ATOM   1061 C CA  . PRO   A 1 154 ? 27.69059  -20.74516 -36.70320 1.000 41.13985 ? 350 PRO   A CA  1 
ATOM   1062 C C   . PRO   A 1 154 ? 26.41224  -19.90302 -36.53008 1.000 36.79470 ? 350 PRO   A C   1 
ATOM   1063 O O   . PRO   A 1 154 ? 25.50222  -20.27030 -35.77036 1.000 36.05819 ? 350 PRO   A O   1 
ATOM   1064 C CB  . PRO   A 1 154 ? 28.45886  -20.83037 -35.39032 1.000 31.63235 ? 350 PRO   A CB  1 
ATOM   1065 C CG  . PRO   A 1 154 ? 29.24536  -19.53747 -35.39300 1.000 40.57102 ? 350 PRO   A CG  1 
ATOM   1066 C CD  . PRO   A 1 154 ? 29.62050  -19.28302 -36.84472 1.000 38.55597 ? 350 PRO   A CD  1 
ATOM   1067 N N   . PHE   A 1 155 ? 26.34540  -18.78244 -37.24667 1.000 36.55974 ? 351 PHE   A N   1 
ATOM   1068 C CA  . PHE   A 1 155 ? 25.25325  -17.83992 -37.03699 1.000 35.27960 ? 351 PHE   A CA  1 
ATOM   1069 C C   . PHE   A 1 155 ? 23.91736  -18.39539 -37.51182 1.000 31.18383 ? 351 PHE   A C   1 
ATOM   1070 O O   . PHE   A 1 155 ? 22.87596  -18.06933 -36.93257 1.000 28.97111 ? 351 PHE   A O   1 
ATOM   1071 C CB  . PHE   A 1 155 ? 25.59172  -16.51894 -37.72518 1.000 30.19052 ? 351 PHE   A CB  1 
ATOM   1072 C CG  . PHE   A 1 155 ? 26.81832  -15.86737 -37.17910 1.000 30.29037 ? 351 PHE   A CG  1 
ATOM   1073 C CD1 . PHE   A 1 155 ? 26.77266  -15.15469 -35.98815 1.000 29.00188 ? 351 PHE   A CD1 1 
ATOM   1074 C CD2 . PHE   A 1 155 ? 28.03750  -15.98851 -37.83646 1.000 32.52851 ? 351 PHE   A CD2 1 
ATOM   1075 C CE1 . PHE   A 1 155 ? 27.89036  -14.56252 -35.47558 1.000 29.79678 ? 351 PHE   A CE1 1 
ATOM   1076 C CE2 . PHE   A 1 155 ? 29.15847  -15.39308 -37.32769 1.000 32.81130 ? 351 PHE   A CE2 1 
ATOM   1077 C CZ  . PHE   A 1 155 ? 29.10191  -14.68611 -36.14998 1.000 34.65192 ? 351 PHE   A CZ  1 
ATOM   1078 N N   . CYS   A 1 156 ? 23.91321  -19.25462 -38.53395 1.000 27.05171 ? 352 CYS   A N   1 
ATOM   1079 C CA  . CYS   A 1 156 ? 22.66031  -19.85182 -38.97899 1.000 27.27713 ? 352 CYS   A CA  1 
ATOM   1080 C C   . CYS   A 1 156 ? 22.08223  -20.84589 -37.97646 1.000 31.63237 ? 352 CYS   A C   1 
ATOM   1081 O O   . CYS   A 1 156 ? 20.93147  -21.25924 -38.14615 1.000 28.47711 ? 352 CYS   A O   1 
ATOM   1082 C CB  . CYS   A 1 156 ? 22.86092  -20.54468 -40.32691 1.000 38.04416 ? 352 CYS   A CB  1 
ATOM   1083 S SG  . CYS   A 1 156 ? 24.14093  -21.80459 -40.24959 1.000 35.71270 ? 352 CYS   A SG  1 
ATOM   1084 N N   . ASP   A 1 157 ? 22.83417  -21.22310 -36.94166 1.000 26.55457 ? 353 ASP   A N   1 
ATOM   1085 C CA  . ASP   A 1 157 ? 22.38875  -22.18354 -35.94223 1.000 33.24629 ? 353 ASP   A CA  1 
ATOM   1086 C C   . ASP   A 1 157 ? 21.78215  -21.53065 -34.70157 1.000 26.28820 ? 353 ASP   A C   1 
ATOM   1087 O O   . ASP   A 1 157 ? 21.40706  -22.24880 -33.76492 1.000 32.72349 ? 353 ASP   A O   1 
ATOM   1088 C CB  . ASP   A 1 157 ? 23.56328  -23.06315 -35.50344 1.000 34.92197 ? 353 ASP   A CB  1 
ATOM   1089 C CG  . ASP   A 1 157 ? 24.11487  -23.91780 -36.63903 1.000 39.80568 ? 353 ASP   A CG  1 
ATOM   1090 O OD1 . ASP   A 1 157 ? 23.30760  -24.44484 -37.42899 1.000 40.89652 ? 353 ASP   A OD1 1 
ATOM   1091 O OD2 . ASP   A 1 157 ? 25.34959  -24.06194 -36.72960 1.000 43.48459 ? 353 ASP   A OD2 1 
ATOM   1092 N N   . ILE   A 1 158 ? 21.70065  -20.20505 -34.65099 1.000 25.60537 ? 354 ILE   A N   1 
ATOM   1093 C CA  . ILE   A 1 158 ? 21.30718  -19.53820 -33.40364 1.000 24.16427 ? 354 ILE   A CA  1 
ATOM   1094 C C   . ILE   A 1 158 ? 19.79378  -19.45498 -33.27255 1.000 25.13006 ? 354 ILE   A C   1 
ATOM   1095 O O   . ILE   A 1 158 ? 19.22879  -19.81537 -32.23195 1.000 26.15923 ? 354 ILE   A O   1 
ATOM   1096 C CB  . ILE   A 1 158 ? 21.94584  -18.13600 -33.30710 1.000 26.05627 ? 354 ILE   A CB  1 
ATOM   1097 C CG1 . ILE   A 1 158 ? 23.47392  -18.22545 -33.28187 1.000 33.33064 ? 354 ILE   A CG1 1 
ATOM   1098 C CG2 . ILE   A 1 158 ? 21.47382  -17.44380 -32.02020 1.000 24.33178 ? 354 ILE   A CG2 1 
ATOM   1099 C CD1 . ILE   A 1 158 ? 24.16722  -16.87140 -33.51753 1.000 28.11984 ? 354 ILE   A CD1 1 
ATOM   1100 N N   . MET   A 1 159 ? 19.10475  -18.94768 -34.29740 1.000 24.71995 ? 355 MET   A N   1 
ATOM   1101 C CA  . MET   A 1 159 ? 17.66220  -18.72824 -34.14187 1.000 23.99392 ? 355 MET   A CA  1 
ATOM   1102 C C   . MET   A 1 159 ? 16.78440  -19.93915 -34.40553 1.000 26.99078 ? 355 MET   A C   1 
ATOM   1103 O O   . MET   A 1 159 ? 15.66080  -19.96717 -33.88851 1.000 25.97130 ? 355 MET   A O   1 
ATOM   1104 C CB  . MET   A 1 159 ? 17.18034  -17.53996 -34.99951 1.000 27.50314 ? 355 MET   A CB  1 
ATOM   1105 C CG  . MET   A 1 159 ? 17.79836  -16.19888 -34.65542 1.000 24.96354 ? 355 MET   A CG  1 
ATOM   1106 S SD  . MET   A 1 159 ? 17.55915  -15.88339 -32.85430 1.000 30.54765 ? 355 MET   A SD  1 
ATOM   1107 C CE  . MET   A 1 159 ? 15.78810  -15.83008 -32.68709 1.000 27.65004 ? 355 MET   A CE  1 
ATOM   1108 N N   . GLU   A 1 160 ? 17.23486  -20.94169 -35.15862 1.000 22.57205 ? 356 GLU   A N   1 
ATOM   1109 C CA  . GLU   A 1 160 ? 16.30600  -22.02278 -35.48780 1.000 30.25601 ? 356 GLU   A CA  1 
ATOM   1110 C C   . GLU   A 1 160 ? 15.73240  -22.73035 -34.25366 1.000 28.01813 ? 356 GLU   A C   1 
ATOM   1111 O O   . GLU   A 1 160 ? 14.51716  -23.00086 -34.25233 1.000 26.11077 ? 356 GLU   A O   1 
ATOM   1112 C CB  . GLU   A 1 160 ? 16.96977  -23.01247 -36.45956 1.000 38.88520 ? 356 GLU   A CB  1 
ATOM   1113 C CG  . GLU   A 1 160 ? 16.00425  -23.99573 -37.11779 1.000 41.20974 ? 356 GLU   A CG  1 
ATOM   1114 C CD  . GLU   A 1 160 ? 14.97827  -23.34201 -38.03796 1.000 40.79527 ? 356 GLU   A CD  1 
ATOM   1115 O OE1 . GLU   A 1 160 ? 15.03800  -22.11280 -38.29946 1.000 36.59026 ? 356 GLU   A OE1 1 
ATOM   1116 O OE2 . GLU   A 1 160 ? 14.08555  -24.07783 -38.50492 1.000 44.48240 ? 356 GLU   A OE2 1 
ATOM   1117 N N   . PRO   A 1 161 ? 16.49728  -23.03343 -33.19299 1.000 22.54451 ? 357 PRO   A N   1 
ATOM   1118 C CA  . PRO   A 1 161 ? 15.86701  -23.65049 -32.01629 1.000 30.08857 ? 357 PRO   A CA  1 
ATOM   1119 C C   . PRO   A 1 161 ? 14.87486  -22.72669 -31.33680 1.000 28.59117 ? 357 PRO   A C   1 
ATOM   1120 O O   . PRO   A 1 161 ? 13.93898  -23.21231 -30.68415 1.000 27.32150 ? 357 PRO   A O   1 
ATOM   1121 C CB  . PRO   A 1 161 ? 17.05180  -23.97356 -31.09488 1.000 28.16400 ? 357 PRO   A CB  1 
ATOM   1122 C CG  . PRO   A 1 161 ? 18.25764  -23.91685 -31.96978 1.000 31.89235 ? 357 PRO   A CG  1 
ATOM   1123 C CD  . PRO   A 1 161 ? 17.96022  -22.92835 -33.03539 1.000 27.03228 ? 357 PRO   A CD  1 
ATOM   1124 N N   . LYS   A 1 162 ? 15.07998  -21.40854 -31.45446 1.000 25.17308 ? 358 LYS   A N   1 
ATOM   1125 C CA  . LYS   A 1 162 ? 14.15219  -20.43649 -30.88509 1.000 28.10295 ? 358 LYS   A CA  1 
ATOM   1126 C C   . LYS   A 1 162 ? 12.84436  -20.41973 -31.66972 1.000 28.80291 ? 358 LYS   A C   1 
ATOM   1127 O O   . LYS   A 1 162 ? 11.75829  -20.32265 -31.07761 1.000 27.40681 ? 358 LYS   A O   1 
ATOM   1128 C CB  . LYS   A 1 162 ? 14.79716  -19.04165 -30.85751 1.000 24.73788 ? 358 LYS   A CB  1 
ATOM   1129 C CG  . LYS   A 1 162 ? 15.83921  -18.80424 -29.75398 1.000 28.30104 ? 358 LYS   A CG  1 
ATOM   1130 C CD  . LYS   A 1 162 ? 17.06190  -19.71581 -29.90197 1.000 27.98511 ? 358 LYS   A CD  1 
ATOM   1131 C CE  . LYS   A 1 162 ? 18.25869  -19.22451 -29.11405 1.000 25.75023 ? 358 LYS   A CE  1 
ATOM   1132 N NZ  . LYS   A 1 162 ? 19.47128  -20.04875 -29.45201 1.000 25.92529 ? 358 LYS   A NZ  1 
ATOM   1133 N N   . PHE   A 1 163 ? 12.92057  -20.53394 -33.00261 1.000 23.19894 ? 359 PHE   A N   1 
ATOM   1134 C CA  . PHE   A 1 163 ? 11.70192  -20.67020 -33.80042 1.000 28.66814 ? 359 PHE   A CA  1 
ATOM   1135 C C   . PHE   A 1 163 ? 10.95615  -21.95651 -33.44807 1.000 23.47866 ? 359 PHE   A C   1 
ATOM   1136 O O   . PHE   A 1 163 ? 9.71795   -21.95919 -33.37155 1.000 25.76006 ? 359 PHE   A O   1 
ATOM   1137 C CB  . PHE   A 1 163 ? 12.01893  -20.65072 -35.30660 1.000 27.50892 ? 359 PHE   A CB  1 
ATOM   1138 C CG  . PHE   A 1 163 ? 12.14916  -19.26235 -35.89731 1.000 23.17954 ? 359 PHE   A CG  1 
ATOM   1139 C CD1 . PHE   A 1 163 ? 11.02747  -18.51243 -36.19636 1.000 24.74440 ? 359 PHE   A CD1 1 
ATOM   1140 C CD2 . PHE   A 1 163 ? 13.40379  -18.70434 -36.13640 1.000 26.93220 ? 359 PHE   A CD2 1 
ATOM   1141 C CE1 . PHE   A 1 163 ? 11.14990  -17.24438 -36.73637 1.000 24.00327 ? 359 PHE   A CE1 1 
ATOM   1142 C CE2 . PHE   A 1 163 ? 13.52886  -17.43839 -36.67704 1.000 22.35902 ? 359 PHE   A CE2 1 
ATOM   1143 C CZ  . PHE   A 1 163 ? 12.39627  -16.70352 -36.96414 1.000 22.31589 ? 359 PHE   A CZ  1 
ATOM   1144 N N   . ASP   A 1 164 ? 11.68667  -23.06647 -33.26315 1.000 22.40233 ? 360 ASP   A N   1 
ATOM   1145 C CA  . ASP   A 1 164 ? 11.03187  -24.32706 -32.89338 1.000 22.20192 ? 360 ASP   A CA  1 
ATOM   1146 C C   . ASP   A 1 164 ? 10.28471  -24.17983 -31.57132 1.000 28.59454 ? 360 ASP   A C   1 
ATOM   1147 O O   . ASP   A 1 164 ? 9.12597   -24.60755 -31.44508 1.000 27.52026 ? 360 ASP   A O   1 
ATOM   1148 C CB  . ASP   A 1 164 ? 12.05057  -25.47120 -32.77464 1.000 26.31266 ? 360 ASP   A CB  1 
ATOM   1149 C CG  . ASP   A 1 164 ? 12.50888  -26.02044 -34.12353 1.000 35.42465 ? 360 ASP   A CG  1 
ATOM   1150 O OD1 . ASP   A 1 164 ? 13.58583  -26.66590 -34.15339 1.000 40.70004 ? 360 ASP   A OD1 1 
ATOM   1151 O OD2 . ASP   A 1 164 ? 11.83565  -25.78388 -35.14691 1.000 35.63000 ? 360 ASP   A OD2 1 
ATOM   1152 N N   . PHE   A 1 165 ? 10.95149  -23.60137 -30.56534 1.000 22.79157 ? 361 PHE   A N   1 
ATOM   1153 C CA  . PHE   A 1 165 ? 10.29935  -23.34132 -29.28414 1.000 22.48157 ? 361 PHE   A CA  1 
ATOM   1154 C C   . PHE   A 1 165 ? 9.05837   -22.47333 -29.46900 1.000 25.36531 ? 361 PHE   A C   1 
ATOM   1155 O O   . PHE   A 1 165 ? 7.98848   -22.78084 -28.92952 1.000 24.64699 ? 361 PHE   A O   1 
ATOM   1156 C CB  . PHE   A 1 165 ? 11.26830  -22.68090 -28.29967 1.000 23.18320 ? 361 PHE   A CB  1 
ATOM   1157 C CG  . PHE   A 1 165 ? 10.59264  -22.25082 -27.01707 1.000 28.08916 ? 361 PHE   A CG  1 
ATOM   1158 C CD1 . PHE   A 1 165 ? 10.43759  -23.14715 -25.97173 1.000 26.09643 ? 361 PHE   A CD1 1 
ATOM   1159 C CD2 . PHE   A 1 165 ? 10.04474  -20.97893 -26.89459 1.000 23.81757 ? 361 PHE   A CD2 1 
ATOM   1160 C CE1 . PHE   A 1 165 ? 9.78653   -22.77149 -24.80068 1.000 26.34264 ? 361 PHE   A CE1 1 
ATOM   1161 C CE2 . PHE   A 1 165 ? 9.38087   -20.59497 -25.72171 1.000 27.73553 ? 361 PHE   A CE2 1 
ATOM   1162 C CZ  . PHE   A 1 165 ? 9.26152   -21.49810 -24.66977 1.000 23.23937 ? 361 PHE   A CZ  1 
ATOM   1163 N N   . ALA   A 1 166 ? 9.17809   -21.38868 -30.24366 1.000 21.55821 ? 362 ALA   A N   1 
ATOM   1164 C CA  . ALA   A 1 166 ? 8.08617   -20.42602 -30.35280 1.000 23.91304 ? 362 ALA   A CA  1 
ATOM   1165 C C   . ALA   A 1 166 ? 6.88070   -20.99263 -31.07868 1.000 26.47846 ? 362 ALA   A C   1 
ATOM   1166 O O   . ALA   A 1 166 ? 5.74490   -20.59694 -30.79127 1.000 23.40883 ? 362 ALA   A O   1 
ATOM   1167 C CB  . ALA   A 1 166 ? 8.55101   -19.16406 -31.06805 1.000 22.74473 ? 362 ALA   A CB  1 
ATOM   1168 N N   . MET   A 1 167 ? 7.09957   -21.87114 -32.05496 1.000 25.63879 ? 363 MET   A N   1 
ATOM   1169 C CA  . MET   A 1 167 ? 5.97543   -22.45789 -32.77532 1.000 26.08972 ? 363 MET   A CA  1 
ATOM   1170 C C   . MET   A 1 167 ? 5.07673   -23.23847 -31.81769 1.000 28.62627 ? 363 MET   A C   1 
ATOM   1171 O O   . MET   A 1 167 ? 3.84851   -23.07056 -31.81868 1.000 28.33668 ? 363 MET   A O   1 
ATOM   1172 C CB  . MET   A 1 167 ? 6.50932   -23.35224 -33.89506 1.000 33.96450 ? 363 MET   A CB  1 
ATOM   1173 C CG  . MET   A 1 167 ? 6.92376   -22.61242 -35.18364 1.000 27.28469 ? 363 MET   A CG  1 
ATOM   1174 S SD  . MET   A 1 167 ? 6.10352   -21.07506 -35.66901 1.000 37.64635 ? 363 MET   A SD  1 
ATOM   1175 C CE  . MET   A 1 167 ? 6.96633   -19.79653 -34.73860 1.000 33.65895 ? 363 MET   A CE  1 
ATOM   1176 N N   . LYS   A 1 168 ? 5.68894   -24.07281 -30.96699 1.000 25.92824 ? 364 LYS   A N   1 
ATOM   1177 C CA  . LYS   A 1 168 ? 4.95480   -24.81678 -29.94595 1.000 32.84216 ? 364 LYS   A CA  1 
ATOM   1178 C C   . LYS   A 1 168 ? 4.39644   -23.90281 -28.85129 1.000 32.77705 ? 364 LYS   A C   1 
ATOM   1179 O O   . LYS   A 1 168 ? 3.26291   -24.10485 -28.39086 1.000 28.82127 ? 364 LYS   A O   1 
ATOM   1180 C CB  . LYS   A 1 168 ? 5.85502   -25.90013 -29.33389 1.000 29.84895 ? 364 LYS   A CB  1 
ATOM   1181 C CG  . LYS   A 1 168 ? 6.42197   -26.92823 -30.32980 1.000 37.56783 ? 364 LYS   A CG  1 
ATOM   1182 C CD  . LYS   A 1 168 ? 5.41016   -27.15905 -31.44803 1.000 49.68596 ? 364 LYS   A CD  1 
ATOM   1183 C CE  . LYS   A 1 168 ? 5.30608   -28.61788 -31.87022 1.000 52.96743 ? 364 LYS   A CE  1 
ATOM   1184 N NZ  . LYS   A 1 168 ? 5.72446   -28.77488 -33.30683 1.000 49.65506 ? 364 LYS   A NZ  1 
ATOM   1185 N N   . PHE   A 1 169 ? 5.17046   -22.90240 -28.41280 1.000 26.18203 ? 365 PHE   A N   1 
ATOM   1186 C CA  . PHE   A 1 169 ? 4.67927   -21.97836 -27.38122 1.000 22.98488 ? 365 PHE   A CA  1 
ATOM   1187 C C   . PHE   A 1 169 ? 3.45645   -21.20533 -27.86238 1.000 26.11899 ? 365 PHE   A C   1 
ATOM   1188 O O   . PHE   A 1 169 ? 2.48528   -21.01636 -27.10916 1.000 26.91178 ? 365 PHE   A O   1 
ATOM   1189 C CB  . PHE   A 1 169 ? 5.79293   -21.00532 -26.98726 1.000 26.15581 ? 365 PHE   A CB  1 
ATOM   1190 C CG  . PHE   A 1 169 ? 5.54160   -20.25033 -25.70235 1.000 21.22809 ? 365 PHE   A CG  1 
ATOM   1191 C CD1 . PHE   A 1 169 ? 5.65858   -20.89057 -24.47600 1.000 28.76502 ? 365 PHE   A CD1 1 
ATOM   1192 C CD2 . PHE   A 1 169 ? 5.22619   -18.89702 -25.73041 1.000 22.04779 ? 365 PHE   A CD2 1 
ATOM   1193 C CE1 . PHE   A 1 169 ? 5.45179   -20.20175 -23.27719 1.000 23.38761 ? 365 PHE   A CE1 1 
ATOM   1194 C CE2 . PHE   A 1 169 ? 5.01864   -18.19033 -24.54368 1.000 23.47452 ? 365 PHE   A CE2 1 
ATOM   1195 C CZ  . PHE   A 1 169 ? 5.14227   -18.85697 -23.30415 1.000 23.96891 ? 365 PHE   A CZ  1 
ATOM   1196 N N   . ASN   A 1 170 ? 3.48910   -20.74368 -29.11656 1.000 24.37075 ? 366 ASN   A N   1 
ATOM   1197 C CA  . ASN   A 1 170 ? 2.39005   -19.97411 -29.67791 1.000 25.99847 ? 366 ASN   A CA  1 
ATOM   1198 C C   . ASN   A 1 170 ? 1.15956   -20.83058 -29.89043 1.000 27.75946 ? 366 ASN   A C   1 
ATOM   1199 O O   . ASN   A 1 170 ? 0.04652   -20.29171 -29.92625 1.000 31.61412 ? 366 ASN   A O   1 
ATOM   1200 C CB  . ASN   A 1 170 ? 2.80385   -19.33367 -31.00289 1.000 19.69758 ? 366 ASN   A CB  1 
ATOM   1201 C CG  . ASN   A 1 170 ? 3.76898   -18.16813 -30.80577 1.000 27.86226 ? 366 ASN   A CG  1 
ATOM   1202 O OD1 . ASN   A 1 170 ? 3.95899   -17.70364 -29.68080 1.000 26.65191 ? 366 ASN   A OD1 1 
ATOM   1203 N ND2 . ASN   A 1 170 ? 4.40095   -17.70932 -31.89335 1.000 23.43738 ? 366 ASN   A ND2 1 
ATOM   1204 N N   . ALA   A 1 171 ? 1.33829   -22.14737 -30.00843 1.000 26.32712 ? 367 ALA   A N   1 
ATOM   1205 C CA  . ALA   A 1 171 ? 0.19881   -23.04105 -30.16385 1.000 31.98173 ? 367 ALA   A CA  1 
ATOM   1206 C C   . ALA   A 1 171 ? -0.66045  -23.07728 -28.91167 1.000 30.87873 ? 367 ALA   A C   1 
ATOM   1207 O O   . ALA   A 1 171 ? -1.81178  -23.52362 -28.97904 1.000 33.26930 ? 367 ALA   A O   1 
ATOM   1208 C CB  . ALA   A 1 171 ? 0.66385   -24.45528 -30.49971 1.000 33.01368 ? 367 ALA   A CB  1 
ATOM   1209 N N   . LEU   A 1 172 ? -0.11814  -22.63617 -27.77460 1.000 31.81121 ? 368 LEU   A N   1 
ATOM   1210 C CA  . LEU   A 1 172 ? -0.89234  -22.54998 -26.53944 1.000 28.57739 ? 368 LEU   A CA  1 
ATOM   1211 C C   . LEU   A 1 172 ? -1.83811  -21.36079 -26.52971 1.000 29.57136 ? 368 LEU   A C   1 
ATOM   1212 O O   . LEU   A 1 172 ? -2.71687  -21.29817 -25.66010 1.000 30.12457 ? 368 LEU   A O   1 
ATOM   1213 C CB  . LEU   A 1 172 ? 0.04144   -22.47085 -25.32969 1.000 26.40489 ? 368 LEU   A CB  1 
ATOM   1214 C CG  . LEU   A 1 172 ? 1.13809   -23.52381 -25.18464 1.000 31.61503 ? 368 LEU   A CG  1 
ATOM   1215 C CD1 . LEU   A 1 172 ? 2.02892   -23.15600 -24.01063 1.000 28.01624 ? 368 LEU   A CD1 1 
ATOM   1216 C CD2 . LEU   A 1 172 ? 0.54233   -24.92874 -25.00883 1.000 33.55118 ? 368 LEU   A CD2 1 
ATOM   1217 N N   . GLU   A 1 173 ? -1.66910  -20.41965 -27.45784 1.000 23.45776 ? 369 GLU   A N   1 
ATOM   1218 C CA  . GLU   A 1 173 ? -2.56712  -19.27801 -27.62083 1.000 27.37151 ? 369 GLU   A CA  1 
ATOM   1219 C C   . GLU   A 1 173 ? -2.68436  -18.46149 -26.33269 1.000 32.51196 ? 369 GLU   A C   1 
ATOM   1220 O O   . GLU   A 1 173 ? -3.77468  -18.03206 -25.94695 1.000 27.03332 ? 369 GLU   A O   1 
ATOM   1221 C CB  . GLU   A 1 173 ? -3.94509  -19.73764 -28.09895 1.000 36.18233 ? 369 GLU   A CB  1 
ATOM   1222 C CG  . GLU   A 1 173 ? -3.90250  -20.43026 -29.45720 1.000 40.12484 ? 369 GLU   A CG  1 
ATOM   1223 C CD  . GLU   A 1 173 ? -4.10989  -19.46442 -30.61282 1.000 55.38170 ? 369 GLU   A CD  1 
ATOM   1224 O OE1 . GLU   A 1 173 ? -3.42687  -18.41077 -30.65424 1.000 55.10823 ? 369 GLU   A OE1 1 
ATOM   1225 O OE2 . GLU   A 1 173 ? -4.96207  -19.76147 -31.48336 1.000 61.99786 ? 369 GLU   A OE2 1 
ATOM   1226 N N   . LEU   A 1 174 ? -1.55355  -18.23741 -25.66221 1.000 24.01118 ? 370 LEU   A N   1 
ATOM   1227 C CA  . LEU   A 1 174 ? -1.53440  -17.31890 -24.52969 1.000 24.96340 ? 370 LEU   A CA  1 
ATOM   1228 C C   . LEU   A 1 174 ? -1.76589  -15.88205 -24.99716 1.000 28.65378 ? 370 LEU   A C   1 
ATOM   1229 O O   . LEU   A 1 174 ? -1.39568  -15.50121 -26.11049 1.000 27.27131 ? 370 LEU   A O   1 
ATOM   1230 C CB  . LEU   A 1 174 ? -0.19454  -17.40261 -23.79528 1.000 27.29763 ? 370 LEU   A CB  1 
ATOM   1231 C CG  . LEU   A 1 174 ? 0.30540   -18.75008 -23.25900 1.000 24.44160 ? 370 LEU   A CG  1 
ATOM   1232 C CD1 . LEU   A 1 174 ? 1.58335   -18.53081 -22.46785 1.000 27.94941 ? 370 LEU   A CD1 1 
ATOM   1233 C CD2 . LEU   A 1 174 ? -0.75055  -19.41395 -22.38493 1.000 26.80852 ? 370 LEU   A CD2 1 
ATOM   1234 N N   . ASP   A 1 175 ? -2.36102  -15.06802 -24.12786 1.000 21.93538 ? 371 ASP   A N   1 
ATOM   1235 C CA  . ASP   A 1 175 ? -2.39373  -13.63301 -24.36860 1.000 24.48966 ? 371 ASP   A CA  1 
ATOM   1236 C C   . ASP   A 1 175 ? -1.46817  -12.92375 -23.38347 1.000 23.67276 ? 371 ASP   A C   1 
ATOM   1237 O O   . ASP   A 1 175 ? -0.84887  -13.55204 -22.51506 1.000 25.31083 ? 371 ASP   A O   1 
ATOM   1238 C CB  . ASP   A 1 175 ? -3.81960  -13.06997 -24.28742 1.000 30.04811 ? 371 ASP   A CB  1 
ATOM   1239 C CG  . ASP   A 1 175 ? -4.47030  -13.27705 -22.93456 1.000 29.47887 ? 371 ASP   A CG  1 
ATOM   1240 O OD1 . ASP   A 1 175 ? -3.83712  -12.97795 -21.88955 1.000 27.96470 ? 371 ASP   A OD1 1 
ATOM   1241 O OD2 . ASP   A 1 175 ? -5.66154  -13.69050 -22.93074 1.000 31.96177 ? 371 ASP   A OD2 1 
ATOM   1242 N N   . ASP   A 1 176 ? -1.37507  -11.59660 -23.53738 1.000 23.65289 ? 372 ASP   A N   1 
ATOM   1243 C CA  . ASP   A 1 176 ? -0.44135  -10.80639 -22.73115 1.000 21.68140 ? 372 ASP   A CA  1 
ATOM   1244 C C   . ASP   A 1 176 ? -0.72586  -10.94144 -21.24014 1.000 23.35967 ? 372 ASP   A C   1 
ATOM   1245 O O   . ASP   A 1 176 ? 0.20561   -10.90214 -20.42972 1.000 23.29459 ? 372 ASP   A O   1 
ATOM   1246 C CB  . ASP   A 1 176 ? -0.48677  -9.33535  -23.13878 1.000 25.49662 ? 372 ASP   A CB  1 
ATOM   1247 C CG  . ASP   A 1 176 ? 0.15884   -9.08152  -24.51711 1.000 29.09653 ? 372 ASP   A CG  1 
ATOM   1248 O OD1 . ASP   A 1 176 ? 1.31062   -9.52660  -24.73974 1.000 27.35184 ? 372 ASP   A OD1 1 
ATOM   1249 O OD2 . ASP   A 1 176 ? -0.51337  -8.46794  -25.38045 1.000 31.66587 ? 372 ASP   A OD2 1 
ATOM   1250 N N   . SER   A 1 177 ? -1.99135  -11.11812 -20.84552 1.000 24.47033 ? 373 SER   A N   1 
ATOM   1251 C CA  . SER   A 1 177 ? -2.22892  -11.30491 -19.41256 1.000 26.00537 ? 373 SER   A CA  1 
ATOM   1252 C C   . SER   A 1 177 ? -1.59925  -12.60904 -18.90670 1.000 25.01436 ? 373 SER   A C   1 
ATOM   1253 O O   . SER   A 1 177 ? -1.09471  -12.65991 -17.77708 1.000 27.94659 ? 373 SER   A O   1 
ATOM   1254 C CB  . SER   A 1 177 ? -3.73320  -11.25040 -19.10757 1.000 23.70343 ? 373 SER   A CB  1 
ATOM   1255 O OG  . SER   A 1 177 ? -4.41393  -12.41090 -19.54084 1.000 21.69181 ? 373 SER   A OG  1 
ATOM   1256 N N   . ASP   A 1 178 ? -1.62255  -13.67216 -19.72337 1.000 19.65795 ? 374 ASP   A N   1 
ATOM   1257 C CA  . ASP   A 1 178 ? -0.97517  -14.93287 -19.35387 1.000 19.77293 ? 374 ASP   A CA  1 
ATOM   1258 C C   . ASP   A 1 178 ? 0.54261   -14.78401 -19.31364 1.000 19.22245 ? 374 ASP   A C   1 
ATOM   1259 O O   . ASP   A 1 178 ? 1.21782   -15.32095 -18.42885 1.000 19.33621 ? 374 ASP   A O   1 
ATOM   1260 C CB  . ASP   A 1 178 ? -1.31789  -16.02486 -20.38013 1.000 21.94050 ? 374 ASP   A CB  1 
ATOM   1261 C CG  . ASP   A 1 178 ? -2.80319  -16.22063 -20.58166 1.000 25.34454 ? 374 ASP   A CG  1 
ATOM   1262 O OD1 . ASP   A 1 178 ? -3.53341  -16.25581 -19.56802 1.000 22.46449 ? 374 ASP   A OD1 1 
ATOM   1263 O OD2 . ASP   A 1 178 ? -3.21376  -16.37600 -21.75437 1.000 26.13946 ? 374 ASP   A OD2 1 
ATOM   1264 N N   . ILE   A 1 179 ? 1.09416   -14.12865 -20.32415 1.000 18.60132 ? 375 ILE   A N   1 
ATOM   1265 C CA  . ILE   A 1 179 ? 2.54148   -14.09298 -20.47977 1.000 19.47768 ? 375 ILE   A CA  1 
ATOM   1266 C C   . ILE   A 1 179 ? 3.17140   -13.27247 -19.36459 1.000 19.34153 ? 375 ILE   A C   1 
ATOM   1267 O O   . ILE   A 1 179 ? 4.24959   -13.61133 -18.86159 1.000 21.39609 ? 375 ILE   A O   1 
ATOM   1268 C CB  . ILE   A 1 179 ? 2.88705   -13.53449 -21.86731 1.000 21.35176 ? 375 ILE   A CB  1 
ATOM   1269 C CG1 . ILE   A 1 179 ? 2.37824   -14.49224 -22.95234 1.000 23.59696 ? 375 ILE   A CG1 1 
ATOM   1270 C CG2 . ILE   A 1 179 ? 4.41377   -13.27570 -21.98927 1.000 20.61466 ? 375 ILE   A CG2 1 
ATOM   1271 C CD1 . ILE   A 1 179 ? 2.27382   -13.83833 -24.32925 1.000 23.22650 ? 375 ILE   A CD1 1 
ATOM   1272 N N   . SER   A 1 180 ? 2.51529   -12.17266 -18.97328 1.000 22.02448 ? 376 SER   A N   1 
ATOM   1273 C CA  . SER   A 1 180 ? 3.04003   -11.33547 -17.90232 1.000 23.31500 ? 376 SER   A CA  1 
ATOM   1274 C C   . SER   A 1 180 ? 3.24955   -12.14755 -16.62905 1.000 20.05753 ? 376 SER   A C   1 
ATOM   1275 O O   . SER   A 1 180 ? 4.27488   -12.00384 -15.95636 1.000 21.77083 ? 376 SER   A O   1 
ATOM   1276 C CB  . SER   A 1 180 ? 2.09857   -10.15330 -17.63947 1.000 23.35098 ? 376 SER   A CB  1 
ATOM   1277 O OG  . SER   A 1 180 ? 0.82481   -10.59679 -17.18498 1.000 23.21684 ? 376 SER   A OG  1 
ATOM   1278 N N   . LEU   A 1 181 ? 2.31785   -13.04221 -16.31419 1.000 19.35375 ? 377 LEU   A N   1 
ATOM   1279 C CA  . LEU   A 1 181 ? 2.46380   -13.86807 -15.11565 1.000 23.08878 ? 377 LEU   A CA  1 
ATOM   1280 C C   . LEU   A 1 181 ? 3.51031   -14.95740 -15.32560 1.000 23.65467 ? 377 LEU   A C   1 
ATOM   1281 O O   . LEU   A 1 181 ? 4.24878   -15.31387 -14.40080 1.000 22.34203 ? 377 LEU   A O   1 
ATOM   1282 C CB  . LEU   A 1 181 ? 1.11381   -14.48491 -14.74802 1.000 19.56458 ? 377 LEU   A CB  1 
ATOM   1283 C CG  . LEU   A 1 181 ? -0.00018  -13.49121 -14.39787 1.000 25.66796 ? 377 LEU   A CG  1 
ATOM   1284 C CD1 . LEU   A 1 181 ? -1.29751  -14.21813 -14.14921 1.000 27.41892 ? 377 LEU   A CD1 1 
ATOM   1285 C CD2 . LEU   A 1 181 ? 0.37333   -12.67062 -13.18161 1.000 28.24121 ? 377 LEU   A CD2 1 
ATOM   1286 N N   . PHE   A 1 182 ? 3.57487   -15.50838 -16.54041 1.000 21.51957 ? 378 PHE   A N   1 
ATOM   1287 C CA  . PHE   A 1 182 ? 4.60184   -16.49789 -16.85309 1.000 21.20760 ? 378 PHE   A CA  1 
ATOM   1288 C C   . PHE   A 1 182 ? 6.00044   -15.89573 -16.69459 1.000 21.96441 ? 378 PHE   A C   1 
ATOM   1289 O O   . PHE   A 1 182 ? 6.88971   -16.50222 -16.07409 1.000 21.79519 ? 378 PHE   A O   1 
ATOM   1290 C CB  . PHE   A 1 182 ? 4.34700   -17.02412 -18.27464 1.000 20.85638 ? 378 PHE   A CB  1 
ATOM   1291 C CG  . PHE   A 1 182 ? 5.29454   -18.10032 -18.71436 1.000 24.21633 ? 378 PHE   A CG  1 
ATOM   1292 C CD1 . PHE   A 1 182 ? 5.19778   -19.38288 -18.19533 1.000 26.36536 ? 378 PHE   A CD1 1 
ATOM   1293 C CD2 . PHE   A 1 182 ? 6.26820   -17.82739 -19.66561 1.000 22.05873 ? 378 PHE   A CD2 1 
ATOM   1294 C CE1 . PHE   A 1 182 ? 6.07799   -20.38355 -18.62135 1.000 27.98889 ? 378 PHE   A CE1 1 
ATOM   1295 C CE2 . PHE   A 1 182 ? 7.14393   -18.81396 -20.10110 1.000 22.92242 ? 378 PHE   A CE2 1 
ATOM   1296 C CZ  . PHE   A 1 182 ? 7.06748   -20.08472 -19.57643 1.000 23.63531 ? 378 PHE   A CZ  1 
ATOM   1297 N N   . VAL   A 1 183 ? 6.19819   -14.67903 -17.21268 1.000 17.26478 ? 379 VAL   A N   1 
ATOM   1298 C CA  . VAL   A 1 183 ? 7.48910   -14.00591 -17.10881 1.000 18.04268 ? 379 VAL   A CA  1 
ATOM   1299 C C   . VAL   A 1 183 ? 7.81992   -13.69241 -15.65317 1.000 22.68129 ? 379 VAL   A C   1 
ATOM   1300 O O   . VAL   A 1 183 ? 8.95395   -13.87771 -15.21574 1.000 19.35654 ? 379 VAL   A O   1 
ATOM   1301 C CB  . VAL   A 1 183 ? 7.49909   -12.74387 -17.98926 1.000 21.11728 ? 379 VAL   A CB  1 
ATOM   1302 C CG1 . VAL   A 1 183 ? 8.77839   -11.91764 -17.77429 1.000 25.28795 ? 379 VAL   A CG1 1 
ATOM   1303 C CG2 . VAL   A 1 183 ? 7.39437   -13.14595 -19.48386 1.000 23.53090 ? 379 VAL   A CG2 1 
ATOM   1304 N N   . ALA   A 1 184 ? 6.84257   -13.21568 -14.88052 1.000 20.43242 ? 380 ALA   A N   1 
ATOM   1305 C CA  . ALA   A 1 184 ? 7.09914   -12.99234 -13.45964 1.000 23.60403 ? 380 ALA   A CA  1 
ATOM   1306 C C   . ALA   A 1 184 ? 7.55565   -14.27185 -12.76028 1.000 24.83706 ? 380 ALA   A C   1 
ATOM   1307 O O   . ALA   A 1 184 ? 8.47245   -14.24162 -11.93755 1.000 25.54099 ? 380 ALA   A O   1 
ATOM   1308 C CB  . ALA   A 1 184 ? 5.84656   -12.44354 -12.78471 1.000 21.63859 ? 380 ALA   A CB  1 
ATOM   1309 N N   . ALA   A 1 185 ? 6.90751   -15.39862 -13.05845 1.000 22.01463 ? 381 ALA   A N   1 
ATOM   1310 C CA  . ALA   A 1 185 ? 7.29377   -16.67833 -12.46484 1.000 24.60923 ? 381 ALA   A CA  1 
ATOM   1311 C C   . ALA   A 1 185 ? 8.70720   -17.10124 -12.86690 1.000 26.01525 ? 381 ALA   A C   1 
ATOM   1312 O O   . ALA   A 1 185 ? 9.44932   -17.66182 -12.05134 1.000 25.56410 ? 381 ALA   A O   1 
ATOM   1313 C CB  . ALA   A 1 185 ? 6.29192   -17.75167 -12.87610 1.000 23.61136 ? 381 ALA   A CB  1 
ATOM   1314 N N   . ILE   A 1 186 ? 9.09327   -16.85501 -14.12196 1.000 21.27766 ? 382 ILE   A N   1 
ATOM   1315 C CA  . ILE   A 1 186 ? 10.46247  -17.14425 -14.55722 1.000 20.84035 ? 382 ILE   A CA  1 
ATOM   1316 C C   . ILE   A 1 186 ? 11.46921  -16.36289 -13.72466 1.000 24.88039 ? 382 ILE   A C   1 
ATOM   1317 O O   . ILE   A 1 186 ? 12.51079  -16.89183 -13.30818 1.000 26.06083 ? 382 ILE   A O   1 
ATOM   1318 C CB  . ILE   A 1 186 ? 10.62436  -16.80737 -16.05283 1.000 18.50619 ? 382 ILE   A CB  1 
ATOM   1319 C CG1 . ILE   A 1 186 ? 9.87809   -17.82429 -16.92281 1.000 24.14325 ? 382 ILE   A CG1 1 
ATOM   1320 C CG2 . ILE   A 1 186 ? 12.12304  -16.70823 -16.41724 1.000 22.84183 ? 382 ILE   A CG2 1 
ATOM   1321 C CD1 . ILE   A 1 186 ? 9.75777   -17.37952 -18.37821 1.000 26.31790 ? 382 ILE   A CD1 1 
ATOM   1322 N N   . ILE   A 1 187 ? 11.18348  -15.08818 -13.47504 1.000 22.07946 ? 383 ILE   A N   1 
ATOM   1323 C CA  . ILE   A 1 187 ? 12.14769  -14.24062 -12.78146 1.000 24.61827 ? 383 ILE   A CA  1 
ATOM   1324 C C   . ILE   A 1 187 ? 12.23852  -14.64383 -11.31415 1.000 29.24742 ? 383 ILE   A C   1 
ATOM   1325 O O   . ILE   A 1 187 ? 13.33020  -14.71860 -10.73109 1.000 25.93323 ? 383 ILE   A O   1 
ATOM   1326 C CB  . ILE   A 1 187 ? 11.76262  -12.76035 -12.94955 1.000 25.77473 ? 383 ILE   A CB  1 
ATOM   1327 C CG1 . ILE   A 1 187 ? 11.87030  -12.35054 -14.41514 1.000 26.00299 ? 383 ILE   A CG1 1 
ATOM   1328 C CG2 . ILE   A 1 187 ? 12.60739  -11.85705 -12.03537 1.000 23.78318 ? 383 ILE   A CG2 1 
ATOM   1329 C CD1 . ILE   A 1 187 ? 11.18980  -11.02448 -14.72309 1.000 30.11561 ? 383 ILE   A CD1 1 
ATOM   1330 N N   . CYS   A 1 188 ? 11.10862  -14.99032 -10.72975 1.000 27.16181 ? 384 CYS   A N   1 
ATOM   1331 C CA  . CYS   A 1 188 ? 11.00518  -15.19837 -9.28938  1.000 28.89892 ? 384 CYS   A CA  1 
ATOM   1332 C C   . CYS   A 1 188 ? 11.20363  -16.67984 -8.96363  1.000 28.16132 ? 384 CYS   A C   1 
ATOM   1333 O O   . CYS   A 1 188 ? 10.30644  -17.37719 -8.51190  1.000 39.45557 ? 384 CYS   A O   1 
ATOM   1334 C CB  . CYS   A 1 188 ? 9.64491   -14.70722 -8.84047  1.000 30.24244 ? 384 CYS   A CB  1 
ATOM   1335 S SG  . CYS   A 1 188 ? 9.72753   -12.94694 -8.70173  1.000 39.08755 ? 384 CYS   A SG  1 
ATOM   1336 N N   . CYS   A 1 189 ? 12.40558  -17.16899 -9.24479  1.000 33.83313 ? 385 CYS   A N   1 
ATOM   1337 C CA  . CYS   A 1 189 ? 12.68785  -18.60095 -9.29022  1.000 33.93438 ? 385 CYS   A CA  1 
ATOM   1338 C C   . CYS   A 1 189 ? 13.68042  -18.93327 -8.18364  1.000 36.24851 ? 385 CYS   A C   1 
ATOM   1339 O O   . CYS   A 1 189 ? 14.82377  -18.46940 -8.21033  1.000 30.70981 ? 385 CYS   A O   1 
ATOM   1340 C CB  . CYS   A 1 189 ? 13.23298  -18.99368 -10.66140 1.000 34.96345 ? 385 CYS   A CB  1 
ATOM   1341 S SG  . CYS   A 1 189 ? 13.78168  -20.69392 -10.74626 1.000 38.85179 ? 385 CYS   A SG  1 
ATOM   1342 N N   . GLY   A 1 190 ? 13.24385  -19.74008 -7.21698  1.000 33.69158 ? 386 GLY   A N   1 
ATOM   1343 C CA  . GLY   A 1 190 ? 14.01371  -19.93528 -5.99987  1.000 36.34574 ? 386 GLY   A CA  1 
ATOM   1344 C C   . GLY   A 1 190 ? 15.23886  -20.81724 -6.14261  1.000 45.35783 ? 386 GLY   A C   1 
ATOM   1345 O O   . GLY   A 1 190 ? 16.04411  -20.87069 -5.20733  1.000 49.76589 ? 386 GLY   A O   1 
ATOM   1346 N N   . ASP   A 1 191 ? 15.40869  -21.50853 -7.26884  1.000 40.86727 ? 387 ASP   A N   1 
ATOM   1347 C CA  . ASP   A 1 191 ? 16.48414  -22.48129 -7.37914  1.000 44.50648 ? 387 ASP   A CA  1 
ATOM   1348 C C   . ASP   A 1 191 ? 17.62035  -22.01153 -8.28341  1.000 45.39372 ? 387 ASP   A C   1 
ATOM   1349 O O   . ASP   A 1 191 ? 18.40437  -22.83186 -8.77090  1.000 50.12864 ? 387 ASP   A O   1 
ATOM   1350 C CB  . ASP   A 1 191 ? 15.90579  -23.83316 -7.80888  1.000 45.17521 ? 387 ASP   A CB  1 
ATOM   1351 C CG  . ASP   A 1 191 ? 15.48464  -23.86884 -9.25449  1.000 52.72003 ? 387 ASP   A CG  1 
ATOM   1352 O OD1 . ASP   A 1 191 ? 15.63168  -22.85287 -9.95612  1.000 53.24617 ? 387 ASP   A OD1 1 
ATOM   1353 O OD2 . ASP   A 1 191 ? 14.97004  -24.92008 -9.68960  1.000 60.94947 ? 387 ASP   A OD2 1 
ATOM   1354 N N   . ARG   A 1 192 ? 17.74471  -20.70646 -8.49366  1.000 37.89134 ? 388 ARG   A N   1 
ATOM   1355 C CA  . ARG   A 1 192 ? 18.91677  -20.18962 -9.18246  1.000 40.21907 ? 388 ARG   A CA  1 
ATOM   1356 C C   . ARG   A 1 192 ? 20.16597  -20.43416 -8.33641  1.000 44.24993 ? 388 ARG   A C   1 
ATOM   1357 O O   . ARG   A 1 192 ? 20.10133  -20.42169 -7.10577  1.000 43.73002 ? 388 ARG   A O   1 
ATOM   1358 C CB  . ARG   A 1 192 ? 18.76759  -18.70068 -9.45333  1.000 37.94307 ? 388 ARG   A CB  1 
ATOM   1359 C CG  . ARG   A 1 192 ? 17.51568  -18.34476 -10.22340 1.000 35.03129 ? 388 ARG   A CG  1 
ATOM   1360 C CD  . ARG   A 1 192 ? 17.36270  -19.16742 -11.51023 1.000 33.80767 ? 388 ARG   A CD  1 
ATOM   1361 N NE  . ARG   A 1 192 ? 16.32359  -18.57227 -12.34014 1.000 29.68164 ? 388 ARG   A NE  1 
ATOM   1362 C CZ  . ARG   A 1 192 ? 15.91270  -19.03666 -13.51248 1.000 31.08535 ? 388 ARG   A CZ  1 
ATOM   1363 N NH1 . ARG   A 1 192 ? 16.44204  -20.12086 -14.05288 1.000 29.47247 ? 388 ARG   A NH1 1 
ATOM   1364 N NH2 . ARG   A 1 192 ? 14.94221  -18.39350 -14.15813 1.000 25.60523 ? 388 ARG   A NH2 1 
ATOM   1365 N N   . PRO   A 1 193 ? 21.31430  -20.67139 -8.97095  1.000 46.06495 ? 389 PRO   A N   1 
ATOM   1366 C CA  . PRO   A 1 193 ? 22.54515  -20.88875 -8.19527  1.000 44.53056 ? 389 PRO   A CA  1 
ATOM   1367 C C   . PRO   A 1 193 ? 22.99761  -19.61514 -7.49424  1.000 43.07251 ? 389 PRO   A C   1 
ATOM   1368 O O   . PRO   A 1 193 ? 23.00747  -18.53090 -8.08161  1.000 40.78985 ? 389 PRO   A O   1 
ATOM   1369 C CB  . PRO   A 1 193 ? 23.56712  -21.34259 -9.24501  1.000 44.82973 ? 389 PRO   A CB  1 
ATOM   1370 C CG  . PRO   A 1 193 ? 22.92595  -21.19380 -10.56653 1.000 42.86046 ? 389 PRO   A CG  1 
ATOM   1371 C CD  . PRO   A 1 193 ? 21.45792  -21.03915 -10.38947 1.000 41.47081 ? 389 PRO   A CD  1 
ATOM   1372 N N   . GLY   A 1 194 ? 23.38060  -19.75769 -6.22839  1.000 45.91802 ? 390 GLY   A N   1 
ATOM   1373 C CA  . GLY   A 1 194 ? 23.97242  -18.66272 -5.48985  1.000 37.91614 ? 390 GLY   A CA  1 
ATOM   1374 C C   . GLY   A 1 194 ? 23.01236  -17.76314 -4.75032  1.000 40.98149 ? 390 GLY   A C   1 
ATOM   1375 O O   . GLY   A 1 194 ? 23.40957  -16.66575 -4.35046  1.000 44.34055 ? 390 GLY   A O   1 
ATOM   1376 N N   . LEU   A 1 195 ? 21.76779  -18.18212 -4.53989  1.000 41.89152 ? 391 LEU   A N   1 
ATOM   1377 C CA  . LEU   A 1 195 ? 20.80800  -17.32418 -3.86296  1.000 37.16483 ? 391 LEU   A CA  1 
ATOM   1378 C C   . LEU   A 1 195 ? 21.05630  -17.33074 -2.35920  1.000 39.96843 ? 391 LEU   A C   1 
ATOM   1379 O O   . LEU   A 1 195 ? 21.32420  -18.37875 -1.76653  1.000 44.51147 ? 391 LEU   A O   1 
ATOM   1380 C CB  . LEU   A 1 195 ? 19.37439  -17.77000 -4.16269  1.000 38.58338 ? 391 LEU   A CB  1 
ATOM   1381 C CG  . LEU   A 1 195 ? 18.88845  -17.41587 -5.57647  1.000 38.78760 ? 391 LEU   A CG  1 
ATOM   1382 C CD1 . LEU   A 1 195 ? 17.56800  -18.10504 -5.87664  1.000 41.23520 ? 391 LEU   A CD1 1 
ATOM   1383 C CD2 . LEU   A 1 195 ? 18.78644  -15.90236 -5.74064  1.000 33.82659 ? 391 LEU   A CD2 1 
ATOM   1384 N N   . LEU   A 1 196 ? 20.96579  -16.14707 -1.74841  1.000 40.92813 ? 392 LEU   A N   1 
ATOM   1385 C CA  . LEU   A 1 196 ? 21.17910  -16.01165 -0.30852  1.000 48.36821 ? 392 LEU   A CA  1 
ATOM   1386 C C   . LEU   A 1 196 ? 19.94494  -16.42779 0.48895   1.000 49.28324 ? 392 LEU   A C   1 
ATOM   1387 O O   . LEU   A 1 196 ? 20.03930  -17.27105 1.38729   1.000 54.55394 ? 392 LEU   A O   1 
ATOM   1388 C CB  . LEU   A 1 196 ? 21.58859  -14.57304 0.03577   1.000 45.12577 ? 392 LEU   A CB  1 
ATOM   1389 C CG  . LEU   A 1 196 ? 22.78429  -13.97661 -0.72152  1.000 48.62806 ? 392 LEU   A CG  1 
ATOM   1390 C CD1 . LEU   A 1 196 ? 23.08411  -12.54909 -0.28755  1.000 49.18981 ? 392 LEU   A CD1 1 
ATOM   1391 C CD2 . LEU   A 1 196 ? 24.01286  -14.84428 -0.55369  1.000 49.50118 ? 392 LEU   A CD2 1 
ATOM   1392 N N   . ASN   A 1 197 ? 18.78360  -15.84844 0.18964   1.000 45.19142 ? 393 ASN   A N   1 
ATOM   1393 C CA  . ASN   A 1 197 ? 17.54862  -16.13947 0.91879   1.000 47.64566 ? 393 ASN   A CA  1 
ATOM   1394 C C   . ASN   A 1 197 ? 16.61548  -16.97080 0.04177   1.000 48.30131 ? 393 ASN   A C   1 
ATOM   1395 O O   . ASN   A 1 197 ? 15.58135  -16.49498 -0.44277  1.000 43.92261 ? 393 ASN   A O   1 
ATOM   1396 C CB  . ASN   A 1 197 ? 16.87479  -14.83887 1.37756   1.000 48.07294 ? 393 ASN   A CB  1 
ATOM   1397 C CG  . ASN   A 1 197 ? 17.81465  -13.94440 2.15948   1.000 59.86533 ? 393 ASN   A CG  1 
ATOM   1398 O OD1 . ASN   A 1 197 ? 18.29017  -12.91912 1.65661   1.000 58.66950 ? 393 ASN   A OD1 1 
ATOM   1399 N ND2 . ASN   A 1 197 ? 18.10087  -14.33647 3.39835   1.000 57.36050 ? 393 ASN   A ND2 1 
ATOM   1400 N N   . VAL   A 1 198 ? 16.98634  -18.24028 -0.14599  1.000 43.85142 ? 394 VAL   A N   1 
ATOM   1401 C CA  . VAL   A 1 198 ? 16.17558  -19.14016 -0.96274  1.000 46.34638 ? 394 VAL   A CA  1 
ATOM   1402 C C   . VAL   A 1 198 ? 14.74551  -19.20317 -0.43596  1.000 43.77159 ? 394 VAL   A C   1 
ATOM   1403 O O   . VAL   A 1 198 ? 13.78759  -19.25986 -1.21591  1.000 41.38998 ? 394 VAL   A O   1 
ATOM   1404 C CB  . VAL   A 1 198 ? 16.82389  -20.53758 -1.02713  1.000 43.13258 ? 394 VAL   A CB  1 
ATOM   1405 C CG1 . VAL   A 1 198 ? 15.90933  -21.51550 -1.72758  1.000 45.24470 ? 394 VAL   A CG1 1 
ATOM   1406 C CG2 . VAL   A 1 198 ? 18.17356  -20.47420 -1.74003  1.000 46.32538 ? 394 VAL   A CG2 1 
ATOM   1407 N N   . GLY   A 1 199 ? 14.57173  -19.14789 0.88904   1.000 38.45548 ? 395 GLY   A N   1 
ATOM   1408 C CA  . GLY   A 1 199 ? 13.23605  -19.29758 1.45706   1.000 37.96016 ? 395 GLY   A CA  1 
ATOM   1409 C C   . GLY   A 1 199 ? 12.28277  -18.16868 1.09406   1.000 41.82753 ? 395 GLY   A C   1 
ATOM   1410 O O   . GLY   A 1 199 ? 11.10681  -18.40732 0.79056   1.000 34.45435 ? 395 GLY   A O   1 
ATOM   1411 N N   . HIS   A 1 200 ? 12.76111  -16.92261 1.14858   1.000 36.68366 ? 396 HIS   A N   1 
ATOM   1412 C CA  . HIS   A 1 200 ? 11.90640  -15.78885 0.79920   1.000 41.10618 ? 396 HIS   A CA  1 
ATOM   1413 C C   . HIS   A 1 200 ? 11.47426  -15.86062 -0.65807  1.000 38.72440 ? 396 HIS   A C   1 
ATOM   1414 O O   . HIS   A 1 200 ? 10.33171  -15.53161 -0.99688  1.000 33.16179 ? 396 HIS   A O   1 
ATOM   1415 C CB  . HIS   A 1 200 ? 12.64782  -14.47601 1.04221   1.000 41.41785 ? 396 HIS   A CB  1 
ATOM   1416 C CG  . HIS   A 1 200 ? 12.95749  -14.21202 2.47667   1.000 48.38531 ? 396 HIS   A CG  1 
ATOM   1417 N ND1 . HIS   A 1 200 ? 12.39507  -14.93756 3.50636   1.000 51.91147 ? 396 HIS   A ND1 1 
ATOM   1418 C CD2 . HIS   A 1 200 ? 13.78726  -13.31242 3.05602   1.000 58.27345 ? 396 HIS   A CD2 1 
ATOM   1419 C CE1 . HIS   A 1 200 ? 12.85644  -14.48613 4.66097   1.000 51.89808 ? 396 HIS   A CE1 1 
ATOM   1420 N NE2 . HIS   A 1 200 ? 13.70428  -13.50221 4.41504   1.000 53.03511 ? 396 HIS   A NE2 1 
ATOM   1421 N N   . ILE   A 1 201 ? 12.39565  -16.25800 -1.53235  1.000 36.82904 ? 397 ILE   A N   1 
ATOM   1422 C CA  . ILE   A 1 201 ? 12.12550  -16.27505 -2.96619  1.000 35.31657 ? 397 ILE   A CA  1 
ATOM   1423 C C   . ILE   A 1 201 ? 11.16505  -17.40236 -3.31462  1.000 33.26612 ? 397 ILE   A C   1 
ATOM   1424 O O   . ILE   A 1 201 ? 10.22548  -17.21656 -4.09900  1.000 31.26224 ? 397 ILE   A O   1 
ATOM   1425 C CB  . ILE   A 1 201 ? 13.45514  -16.37925 -3.72267  1.000 35.27077 ? 397 ILE   A CB  1 
ATOM   1426 C CG1 . ILE   A 1 201 ? 14.28147  -15.12649 -3.44254  1.000 38.11000 ? 397 ILE   A CG1 1 
ATOM   1427 C CG2 . ILE   A 1 201 ? 13.22486  -16.55857 -5.21648  1.000 36.38956 ? 397 ILE   A CG2 1 
ATOM   1428 C CD1 . ILE   A 1 201 ? 15.67766  -15.18880 -3.97985  1.000 35.55649 ? 397 ILE   A CD1 1 
ATOM   1429 N N   . GLU   A 1 202 ? 11.37080  -18.58309 -2.72406  1.000 38.33709 ? 398 GLU   A N   1 
ATOM   1430 C CA  . GLU   A 1 202 ? 10.41660  -19.67485 -2.89802  1.000 38.23403 ? 398 GLU   A CA  1 
ATOM   1431 C C   . GLU   A 1 202 ? 9.01701   -19.25094 -2.48081  1.000 35.69435 ? 398 GLU   A C   1 
ATOM   1432 O O   . GLU   A 1 202 ? 8.04255   -19.53531 -3.18529  1.000 34.38507 ? 398 GLU   A O   1 
ATOM   1433 C CB  . GLU   A 1 202 ? 10.86668  -20.90463 -2.10775  1.000 39.41193 ? 398 GLU   A CB  1 
ATOM   1434 C CG  . GLU   A 1 202 ? 12.15728  -21.53530 -2.63873  1.000 44.45551 ? 398 GLU   A CG  1 
ATOM   1435 C CD  . GLU   A 1 202 ? 12.52485  -22.83676 -1.93365  1.000 52.49618 ? 398 GLU   A CD  1 
ATOM   1436 O OE1 . GLU   A 1 202 ? 12.35201  -22.92496 -0.69278  1.000 51.13155 ? 398 GLU   A OE1 1 
ATOM   1437 O OE2 . GLU   A 1 202 ? 12.99629  -23.76895 -2.62925  1.000 55.35313 ? 398 GLU   A OE2 1 
ATOM   1438 N N   . LYS   A 1 203 ? 8.89410   -18.55532 -1.34392  1.000 34.61839 ? 399 LYS   A N   1 
ATOM   1439 C CA  . LYS   A 1 203 ? 7.58269   -18.07832 -0.91095  1.000 32.37230 ? 399 LYS   A CA  1 
ATOM   1440 C C   . LYS   A 1 203 ? 7.01178   -17.08607 -1.91181  1.000 31.48887 ? 399 LYS   A C   1 
ATOM   1441 O O   . LYS   A 1 203 ? 5.80580   -17.08266 -2.19485  1.000 31.43655 ? 399 LYS   A O   1 
ATOM   1442 C CB  . LYS   A 1 203 ? 7.68780   -17.40744 0.45456   1.000 33.27376 ? 399 LYS   A CB  1 
ATOM   1443 C CG  . LYS   A 1 203 ? 7.32158   -18.29220 1.62588   1.000 44.57780 ? 399 LYS   A CG  1 
ATOM   1444 C CD  . LYS   A 1 203 ? 8.22693   -19.51962 1.71349   1.000 48.10040 ? 399 LYS   A CD  1 
ATOM   1445 C CE  . LYS   A 1 203 ? 7.90843   -20.36389 2.95245   1.000 43.54728 ? 399 LYS   A CE  1 
ATOM   1446 N NZ  . LYS   A 1 203 ? 9.14966   -20.96716 3.52058   1.000 49.00683 ? 399 LYS   A NZ  1 
ATOM   1447 N N   . MET   A 1 204 ? 7.86592   -16.22429 -2.44641  1.000 30.81855 ? 400 MET   A N   1 
ATOM   1448 C CA  . MET   A 1 204 ? 7.38377   -15.20978 -3.36775  1.000 39.29328 ? 400 MET   A CA  1 
ATOM   1449 C C   . MET   A 1 204 ? 6.91110   -15.87646 -4.65070  1.000 33.96952 ? 400 MET   A C   1 
ATOM   1450 O O   . MET   A 1 204 ? 5.86010   -15.51822 -5.19944  1.000 33.68759 ? 400 MET   A O   1 
ATOM   1451 C CB  . MET   A 1 204 ? 8.50933   -14.21108 -3.63050  1.000 38.44710 ? 400 MET   A CB  1 
ATOM   1452 C CG  . MET   A 1 204 ? 8.06823   -12.79529 -3.85613  1.000 46.79765 ? 400 MET   A CG  1 
ATOM   1453 S SD  . MET   A 1 204 ? 9.40962   -11.73723 -4.41060  1.000 52.80817 ? 400 MET   A SD  1 
ATOM   1454 C CE  . MET   A 1 204 ? 8.93288   -11.48570 -6.09004  1.000 42.04024 ? 400 MET   A CE  1 
ATOM   1455 N N   . GLN   A 1 205 ? 7.65211   -16.89870 -5.09966  1.000 28.62638 ? 401 GLN   A N   1 
ATOM   1456 C CA  . GLN   A 1 205 ? 7.26816   -17.64205 -6.29674  1.000 31.90196 ? 401 GLN   A CA  1 
ATOM   1457 C C   . GLN   A 1 205 ? 5.98795   -18.43295 -6.09165  1.000 33.97132 ? 401 GLN   A C   1 
ATOM   1458 O O   . GLN   A 1 205 ? 5.18115   -18.55983 -7.02004  1.000 32.46757 ? 401 GLN   A O   1 
ATOM   1459 C CB  . GLN   A 1 205 ? 8.37313   -18.59960 -6.72404  1.000 38.34867 ? 401 GLN   A CB  1 
ATOM   1460 C CG  . GLN   A 1 205 ? 8.02006   -19.31222 -8.02545  1.000 39.99972 ? 401 GLN   A CG  1 
ATOM   1461 C CD  . GLN   A 1 205 ? 9.10762   -20.23071 -8.49860  1.000 39.09480 ? 401 GLN   A CD  1 
ATOM   1462 O OE1 . GLN   A 1 205 ? 9.56172   -21.10622 -7.75635  1.000 46.00261 ? 401 GLN   A OE1 1 
ATOM   1463 N NE2 . GLN   A 1 205 ? 9.54751   -20.03597 -9.74431  1.000 48.60404 ? 401 GLN   A NE2 1 
ATOM   1464 N N   . GLU   A 1 206 ? 5.79723   -19.00178 -4.89748  1.000 30.71283 ? 402 GLU   A N   1 
ATOM   1465 C CA  . GLU   A 1 206 ? 4.58357   -19.76931 -4.64873  1.000 29.84379 ? 402 GLU   A CA  1 
ATOM   1466 C C   . GLU   A 1 206 ? 3.34726   -18.90311 -4.83718  1.000 27.85426 ? 402 GLU   A C   1 
ATOM   1467 O O   . GLU   A 1 206 ? 2.34484   -19.36050 -5.39402  1.000 28.90479 ? 402 GLU   A O   1 
ATOM   1468 C CB  . GLU   A 1 206 ? 4.61720   -20.39169 -3.24285  1.000 35.66389 ? 402 GLU   A CB  1 
ATOM   1469 C CG  . GLU   A 1 206 ? 3.30015   -21.06007 -2.82418  1.000 35.05154 ? 402 GLU   A CG  1 
ATOM   1470 C CD  . GLU   A 1 206 ? 3.14615   -21.18064 -1.30262  1.000 55.15852 ? 402 GLU   A CD  1 
ATOM   1471 O OE1 . GLU   A 1 206 ? 2.01506   -21.01522 -0.79736  1.000 54.92098 ? 402 GLU   A OE1 1 
ATOM   1472 O OE2 . GLU   A 1 206 ? 4.15060   -21.47174 -0.61339  1.000 55.99069 ? 402 GLU   A OE2 1 
ATOM   1473 N N   . GLY   A 1 207 ? 3.40794   -17.64159 -4.40803  1.000 26.15099 ? 403 GLY   A N   1 
ATOM   1474 C CA  . GLY   A 1 207 ? 2.26890   -16.75557 -4.59553  1.000 29.83205 ? 403 GLY   A CA  1 
ATOM   1475 C C   . GLY   A 1 207 ? 2.03682   -16.40308 -6.05544  1.000 29.49788 ? 403 GLY   A C   1 
ATOM   1476 O O   . GLY   A 1 207 ? 0.89297   -16.35203 -6.51538  1.000 28.62903 ? 403 GLY   A O   1 
ATOM   1477 N N   . ILE   A 1 208 ? 3.11384   -16.15747 -6.80505  1.000 27.85169 ? 404 ILE   A N   1 
ATOM   1478 C CA  . ILE   A 1 208 ? 2.96888   -15.85684 -8.22950  1.000 23.87471 ? 404 ILE   A CA  1 
ATOM   1479 C C   . ILE   A 1 208 ? 2.41108   -17.06363 -8.97494  1.000 23.82465 ? 404 ILE   A C   1 
ATOM   1480 O O   . ILE   A 1 208 ? 1.46298   -16.94664 -9.76179  1.000 27.26091 ? 404 ILE   A O   1 
ATOM   1481 C CB  . ILE   A 1 208 ? 4.31282   -15.39851 -8.82141  1.000 26.59850 ? 404 ILE   A CB  1 
ATOM   1482 C CG1 . ILE   A 1 208 ? 4.69120   -14.02058 -8.26885  1.000 27.94275 ? 404 ILE   A CG1 1 
ATOM   1483 C CG2 . ILE   A 1 208 ? 4.23328   -15.37265 -10.37879 1.000 23.93731 ? 404 ILE   A CG2 1 
ATOM   1484 C CD1 . ILE   A 1 208 ? 6.16205   -13.67372 -8.42536  1.000 34.67296 ? 404 ILE   A CD1 1 
ATOM   1485 N N   . VAL   A 1 209 ? 2.98448   -18.24629 -8.73683  1.000 26.55288 ? 405 VAL   A N   1 
ATOM   1486 C CA  . VAL   A 1 209 ? 2.50650   -19.45494 -9.41178  1.000 28.32424 ? 405 VAL   A CA  1 
ATOM   1487 C C   . VAL   A 1 209 ? 1.05722   -19.75067 -9.04208  1.000 33.15041 ? 405 VAL   A C   1 
ATOM   1488 O O   . VAL   A 1 209 ? 0.27914   -20.23057 -9.87147  1.000 30.11332 ? 405 VAL   A O   1 
ATOM   1489 C CB  . VAL   A 1 209 ? 3.43822   -20.63977 -9.07303  1.000 30.74937 ? 405 VAL   A CB  1 
ATOM   1490 C CG1 . VAL   A 1 209 ? 2.83443   -21.94906 -9.52236  1.000 40.58983 ? 405 VAL   A CG1 1 
ATOM   1491 C CG2 . VAL   A 1 209 ? 4.78374   -20.44706 -9.72514  1.000 30.16564 ? 405 VAL   A CG2 1 
ATOM   1492 N N   . HIS   A 1 210 ? 0.66375   -19.45554 -7.80343  1.000 29.30553 ? 406 HIS   A N   1 
ATOM   1493 C CA  . HIS   A 1 210 ? -0.72531  -19.64892 -7.41856  1.000 30.94564 ? 406 HIS   A CA  1 
ATOM   1494 C C   . HIS   A 1 210 ? -1.63951  -18.73640 -8.22107  1.000 28.55181 ? 406 HIS   A C   1 
ATOM   1495 O O   . HIS   A 1 210 ? -2.67950  -19.17124 -8.72309  1.000 26.93573 ? 406 HIS   A O   1 
ATOM   1496 C CB  . HIS   A 1 210 ? -0.88676  -19.39008 -5.91876  1.000 30.95005 ? 406 HIS   A CB  1 
ATOM   1497 C CG  . HIS   A 1 210 ? -2.26603  -19.65275 -5.40840  1.000 38.83474 ? 406 HIS   A CG  1 
ATOM   1498 N ND1 . HIS   A 1 210 ? -2.90174  -18.81786 -4.51751  1.000 42.95211 ? 406 HIS   A ND1 1 
ATOM   1499 C CD2 . HIS   A 1 210 ? -3.12566  -20.67182 -5.64899  1.000 46.45278 ? 406 HIS   A CD2 1 
ATOM   1500 C CE1 . HIS   A 1 210 ? -4.09859  -19.30423 -4.23845  1.000 43.82518 ? 406 HIS   A CE1 1 
ATOM   1501 N NE2 . HIS   A 1 210 ? -4.25703  -20.43172 -4.90730  1.000 43.75549 ? 406 HIS   A NE2 1 
ATOM   1502 N N   . VAL   A 1 211 ? -1.24150  -17.47717 -8.39665  1.000 28.21181 ? 407 VAL   A N   1 
ATOM   1503 C CA  . VAL   A 1 211 ? -2.06463  -16.54773 -9.16174  1.000 26.07215 ? 407 VAL   A CA  1 
ATOM   1504 C C   . VAL   A 1 211 ? -2.05288  -16.91399 -10.65280 1.000 29.36686 ? 407 VAL   A C   1 
ATOM   1505 O O   . VAL   A 1 211 ? -3.07576  -16.79081 -11.34426 1.000 27.86207 ? 407 VAL   A O   1 
ATOM   1506 C CB  . VAL   A 1 211 ? -1.58772  -15.11032 -8.88520  1.000 33.13723 ? 407 VAL   A CB  1 
ATOM   1507 C CG1 . VAL   A 1 211 ? -1.97813  -14.16443 -9.99131  1.000 35.17392 ? 407 VAL   A CG1 1 
ATOM   1508 C CG2 . VAL   A 1 211 ? -2.16492  -14.63602 -7.53491  1.000 32.83483 ? 407 VAL   A CG2 1 
ATOM   1509 N N   . LEU   A 1 212 ? -0.92655  -17.41948 -11.15727 1.000 27.43573 ? 408 LEU   A N   1 
ATOM   1510 C CA  . LEU   A 1 212 ? -0.89510  -17.90183 -12.54240 1.000 23.57195 ? 408 LEU   A CA  1 
ATOM   1511 C C   . LEU   A 1 212 ? -1.83775  -19.09031 -12.73180 1.000 24.40107 ? 408 LEU   A C   1 
ATOM   1512 O O   . LEU   A 1 212 ? -2.60140  -19.14479 -13.70050 1.000 26.82246 ? 408 LEU   A O   1 
ATOM   1513 C CB  . LEU   A 1 212 ? 0.54399   -18.26305 -12.94506 1.000 26.11508 ? 408 LEU   A CB  1 
ATOM   1514 C CG  . LEU   A 1 212 ? 0.70096   -19.11502 -14.21225 1.000 25.58003 ? 408 LEU   A CG  1 
ATOM   1515 C CD1 . LEU   A 1 212 ? 0.33594   -18.29962 -15.44470 1.000 26.51137 ? 408 LEU   A CD1 1 
ATOM   1516 C CD2 . LEU   A 1 212 ? 2.11686   -19.66063 -14.34049 1.000 21.86783 ? 408 LEU   A CD2 1 
ATOM   1517 N N   . ARG   A 1 213 ? -1.80579  -20.05700 -11.80903 1.000 23.50844 ? 409 ARG   A N   1 
ATOM   1518 C CA  . ARG   A 1 213 ? -2.70173  -21.20641 -11.91200 1.000 29.98289 ? 409 ARG   A CA  1 
ATOM   1519 C C   . ARG   A 1 213 ? -4.16418  -20.76374 -11.95814 1.000 26.18833 ? 409 ARG   A C   1 
ATOM   1520 O O   . ARG   A 1 213 ? -4.93318  -21.19521 -12.82364 1.000 26.97201 ? 409 ARG   A O   1 
ATOM   1521 C CB  . ARG   A 1 213 ? -2.44876  -22.15566 -10.73566 1.000 30.19356 ? 409 ARG   A CB  1 
ATOM   1522 C CG  . ARG   A 1 213 ? -3.32999  -23.38417 -10.69291 1.000 35.01294 ? 409 ARG   A CG  1 
ATOM   1523 C CD  . ARG   A 1 213 ? -3.18980  -24.07800 -9.32701  1.000 43.75094 ? 409 ARG   A CD  1 
ATOM   1524 N NE  . ARG   A 1 213 ? -1.80850  -24.46670 -9.05201  1.000 46.72239 ? 409 ARG   A NE  1 
ATOM   1525 C CZ  . ARG   A 1 213 ? -1.07160  -23.99319 -8.05108  1.000 49.52869 ? 409 ARG   A CZ  1 
ATOM   1526 N NH1 . ARG   A 1 213 ? 0.18743   -24.37480 -7.87602  1.000 45.45393 ? 409 ARG   A NH1 1 
ATOM   1527 N NH2 . ARG   A 1 213 ? -1.60551  -23.10587 -7.21191  1.000 46.82920 ? 409 ARG   A NH2 1 
ATOM   1528 N N   . LEU   A 1 214 ? -4.56800  -19.89201 -11.03365 1.000 30.18145 ? 410 LEU   A N   1 
ATOM   1529 C CA  . LEU   A 1 214 ? -5.95656  -19.43936 -11.02945 1.000 27.10018 ? 410 LEU   A CA  1 
ATOM   1530 C C   . LEU   A 1 214 ? -6.28240  -18.66858 -12.29722 1.000 28.64270 ? 410 LEU   A C   1 
ATOM   1531 O O   . LEU   A 1 214 ? -7.38438  -18.80035 -12.84707 1.000 28.00432 ? 410 LEU   A O   1 
ATOM   1532 C CB  . LEU   A 1 214 ? -6.22145  -18.56880 -9.81059  1.000 34.10486 ? 410 LEU   A CB  1 
ATOM   1533 C CG  . LEU   A 1 214 ? -6.15621  -19.32090 -8.48298  1.000 40.43246 ? 410 LEU   A CG  1 
ATOM   1534 C CD1 . LEU   A 1 214 ? -6.53197  -18.37718 -7.35815  1.000 39.25419 ? 410 LEU   A CD1 1 
ATOM   1535 C CD2 . LEU   A 1 214 ? -7.05528  -20.55919 -8.48610  1.000 41.91819 ? 410 LEU   A CD2 1 
ATOM   1536 N N   . HIS   A 1 215 ? -5.32357  -17.86574 -12.78266 1.000 25.10460 ? 411 HIS   A N   1 
ATOM   1537 C CA  . HIS   A 1 215 ? -5.56240  -17.07420 -13.98475 1.000 27.50899 ? 411 HIS   A CA  1 
ATOM   1538 C C   . HIS   A 1 215 ? -5.75336  -17.96428 -15.20762 1.000 27.80995 ? 411 HIS   A C   1 
ATOM   1539 O O   . HIS   A 1 215 ? -6.63495  -17.70538 -16.04011 1.000 25.01623 ? 411 HIS   A O   1 
ATOM   1540 C CB  . HIS   A 1 215 ? -4.41615  -16.07707 -14.19695 1.000 25.37340 ? 411 HIS   A CB  1 
ATOM   1541 C CG  . HIS   A 1 215 ? -4.59415  -15.20575 -15.40249 1.000 25.21329 ? 411 HIS   A CG  1 
ATOM   1542 N ND1 . HIS   A 1 215 ? -5.40654  -14.09172 -15.40518 1.000 28.07952 ? 411 HIS   A ND1 1 
ATOM   1543 C CD2 . HIS   A 1 215 ? -4.07503  -15.29614 -16.65388 1.000 32.34784 ? 411 HIS   A CD2 1 
ATOM   1544 C CE1 . HIS   A 1 215 ? -5.37741  -13.53156 -16.60300 1.000 35.71286 ? 411 HIS   A CE1 1 
ATOM   1545 N NE2 . HIS   A 1 215 ? -4.57850  -14.24394 -17.38024 1.000 24.96942 ? 411 HIS   A NE2 1 
ATOM   1546 N N   . LEU   A 1 216 ? -4.92982  -19.00834 -15.34930 1.000 23.83631 ? 412 LEU   A N   1 
ATOM   1547 C CA  . LEU   A 1 216 ? -5.08710  -19.91163 -16.48851 1.000 22.82552 ? 412 LEU   A CA  1 
ATOM   1548 C C   . LEU   A 1 216 ? -6.43432  -20.62944 -16.45327 1.000 28.30700 ? 412 LEU   A C   1 
ATOM   1549 O O   . LEU   A 1 216 ? -7.06092  -20.86392 -17.49955 1.000 25.51508 ? 412 LEU   A O   1 
ATOM   1550 C CB  . LEU   A 1 216 ? -3.94216  -20.92810 -16.50938 1.000 21.51115 ? 412 LEU   A CB  1 
ATOM   1551 C CG  . LEU   A 1 216 ? -2.55943  -20.30741 -16.71063 1.000 20.83838 ? 412 LEU   A CG  1 
ATOM   1552 C CD1 . LEU   A 1 216 ? -1.49662  -21.40966 -16.55807 1.000 21.05296 ? 412 LEU   A CD1 1 
ATOM   1553 C CD2 . LEU   A 1 216 ? -2.43992  -19.61064 -18.07949 1.000 24.29047 ? 412 LEU   A CD2 1 
ATOM   1554 N N   . GLN   A 1 217 ? -6.89937  -20.99701 -15.26159 1.000 28.19393 ? 413 GLN   A N   1 
ATOM   1555 C CA  . GLN   A 1 217 ? -8.17585  -21.69686 -15.19425 1.000 31.41826 ? 413 GLN   A CA  1 
ATOM   1556 C C   . GLN   A 1 217 ? -9.33803  -20.78316 -15.59859 1.000 29.13559 ? 413 GLN   A C   1 
ATOM   1557 O O   . GLN   A 1 217 ? -10.29562 -21.25359 -16.22250 1.000 36.45901 ? 413 GLN   A O   1 
ATOM   1558 C CB  . GLN   A 1 217 ? -8.36172  -22.29127 -13.79166 1.000 36.71438 ? 413 GLN   A CB  1 
ATOM   1559 C CG  . GLN   A 1 217 ? -9.75999  -22.20273 -13.21772 1.000 44.58044 ? 413 GLN   A CG  1 
ATOM   1560 C CD  . GLN   A 1 217 ? -9.85022  -22.76230 -11.79044 1.000 58.76085 ? 413 GLN   A CD  1 
ATOM   1561 O OE1 . GLN   A 1 217 ? -8.86845  -22.76846 -11.03286 1.000 53.29427 ? 413 GLN   A OE1 1 
ATOM   1562 N NE2 . GLN   A 1 217 ? -11.03128 -23.26056 -11.43332 1.000 60.61750 ? 413 GLN   A NE2 1 
ATOM   1563 N N   . SER   A 1 218 ? -9.25545  -19.47516 -15.31327 1.000 29.29566 ? 414 SER   A N   1 
ATOM   1564 C CA  . SER   A 1 218 ? -10.32869 -18.56397 -15.72325 1.000 32.82818 ? 414 SER   A CA  1 
ATOM   1565 C C   . SER   A 1 218 ? -10.20564 -18.15935 -17.18182 1.000 36.21051 ? 414 SER   A C   1 
ATOM   1566 O O   . SER   A 1 218 ? -11.22278 -18.04827 -17.88104 1.000 30.73066 ? 414 SER   A O   1 
ATOM   1567 C CB  . SER   A 1 218 ? -10.35277 -17.29624 -14.86532 1.000 33.56029 ? 414 SER   A CB  1 
ATOM   1568 O OG  . SER   A 1 218 ? -10.40063 -17.62155 -13.49742 1.000 42.40075 ? 414 SER   A OG  1 
ATOM   1569 N N   . ASN   A 1 219 ? -8.96972  -17.93226 -17.65230 1.000 29.53782 ? 415 ASN   A N   1 
ATOM   1570 C CA  . ASN   A 1 219 ? -8.74458  -17.38270 -18.97618 1.000 26.93133 ? 415 ASN   A CA  1 
ATOM   1571 C C   . ASN   A 1 219 ? -8.73731  -18.45344 -20.05677 1.000 25.87179 ? 415 ASN   A C   1 
ATOM   1572 O O   . ASN   A 1 219 ? -8.97374  -18.13237 -21.22562 1.000 25.29897 ? 415 ASN   A O   1 
ATOM   1573 C CB  . ASN   A 1 219 ? -7.42035  -16.59952 -19.00794 1.000 28.68579 ? 415 ASN   A CB  1 
ATOM   1574 C CG  . ASN   A 1 219 ? -7.37582  -15.57287 -20.13942 1.000 32.66998 ? 415 ASN   A CG  1 
ATOM   1575 O OD1 . ASN   A 1 219 ? -8.41341  -15.05588 -20.53378 1.000 29.48911 ? 415 ASN   A OD1 1 
ATOM   1576 N ND2 . ASN   A 1 219 ? -6.16766  -15.28654 -20.67713 1.000 29.78438 ? 415 ASN   A ND2 1 
ATOM   1577 N N   . HIS   A 1 220 ? -8.48687  -19.70925 -19.68318 1.000 23.02717 ? 416 HIS   A N   1 
ATOM   1578 C CA  . HIS   A 1 220 ? -8.37710  -20.83199 -20.61484 1.000 26.56681 ? 416 HIS   A CA  1 
ATOM   1579 C C   . HIS   A 1 220 ? -9.15590  -22.02726 -20.08150 1.000 32.74416 ? 416 HIS   A C   1 
ATOM   1580 O O   . HIS   A 1 220 ? -8.58547  -23.09322 -19.81064 1.000 25.79574 ? 416 HIS   A O   1 
ATOM   1581 C CB  . HIS   A 1 220 ? -6.90794  -21.20122 -20.84250 1.000 27.00164 ? 416 HIS   A CB  1 
ATOM   1582 C CG  . HIS   A 1 220 ? -6.12611  -20.12416 -21.51650 1.000 28.53113 ? 416 HIS   A CG  1 
ATOM   1583 N ND1 . HIS   A 1 220 ? -5.96913  -20.06934 -22.88489 1.000 30.87375 ? 416 HIS   A ND1 1 
ATOM   1584 C CD2 . HIS   A 1 220 ? -5.44922  -19.06247 -21.01389 1.000 25.74215 ? 416 HIS   A CD2 1 
ATOM   1585 C CE1 . HIS   A 1 220 ? -5.24708  -19.00574 -23.19753 1.000 30.19370 ? 416 HIS   A CE1 1 
ATOM   1586 N NE2 . HIS   A 1 220 ? -4.92387  -18.37698 -22.08064 1.000 25.58076 ? 416 HIS   A NE2 1 
ATOM   1587 N N   . PRO   A 1 221 ? -10.47960 -21.88651 -19.92523 1.000 30.53871 ? 417 PRO   A N   1 
ATOM   1588 C CA  . PRO   A 1 221 ? -11.27237 -22.98571 -19.35315 1.000 33.91446 ? 417 PRO   A CA  1 
ATOM   1589 C C   . PRO   A 1 221 ? -11.32229 -24.21489 -20.24220 1.000 37.08814 ? 417 PRO   A C   1 
ATOM   1590 O O   . PRO   A 1 221 ? -11.75158 -25.28180 -19.78645 1.000 40.84810 ? 417 PRO   A O   1 
ATOM   1591 C CB  . PRO   A 1 221 ? -12.66473 -22.35997 -19.18419 1.000 35.43818 ? 417 PRO   A CB  1 
ATOM   1592 C CG  . PRO   A 1 221 ? -12.74469 -21.33870 -20.26602 1.000 34.13857 ? 417 PRO   A CG  1 
ATOM   1593 C CD  . PRO   A 1 221 ? -11.32838 -20.77755 -20.40506 1.000 32.48603 ? 417 PRO   A CD  1 
ATOM   1594 N N   . ASP   A 1 222 ? -10.86468 -24.10846 -21.48119 1.000 30.12995 ? 418 ASP   A N   1 
ATOM   1595 C CA  . ASP   A 1 222 ? -10.92700 -25.19539 -22.43745 1.000 36.36027 ? 418 ASP   A CA  1 
ATOM   1596 C C   . ASP   A 1 222 ? -9.71020  -26.11271 -22.39467 1.000 37.32430 ? 418 ASP   A C   1 
ATOM   1597 O O   . ASP   A 1 222 ? -9.72277  -27.15754 -23.05634 1.000 41.06548 ? 418 ASP   A O   1 
ATOM   1598 C CB  . ASP   A 1 222 ? -11.07832 -24.61225 -23.84697 1.000 34.36158 ? 418 ASP   A CB  1 
ATOM   1599 C CG  . ASP   A 1 222 ? -10.00227 -23.56381 -24.17548 1.000 43.32431 ? 418 ASP   A CG  1 
ATOM   1600 O OD1 . ASP   A 1 222 ? -9.69000  -22.70243 -23.32794 1.000 36.14624 ? 418 ASP   A OD1 1 
ATOM   1601 O OD2 . ASP   A 1 222 ? -9.46379  -23.59855 -25.29564 1.000 46.74813 ? 418 ASP   A OD2 1 
ATOM   1602 N N   . ASP   A 1 223 ? -8.65995  -25.74834 -21.65280 1.000 31.08726 ? 419 ASP   A N   1 
ATOM   1603 C CA  . ASP   A 1 223 ? -7.37390  -26.46383 -21.67829 1.000 28.77193 ? 419 ASP   A CA  1 
ATOM   1604 C C   . ASP   A 1 223 ? -7.00728  -26.78691 -20.24267 1.000 27.82290 ? 419 ASP   A C   1 
ATOM   1605 O O   . ASP   A 1 223 ? -6.34227  -25.98531 -19.57497 1.000 27.45768 ? 419 ASP   A O   1 
ATOM   1606 C CB  . ASP   A 1 223 ? -6.28494  -25.63673 -22.36347 1.000 26.61742 ? 419 ASP   A CB  1 
ATOM   1607 C CG  . ASP   A 1 223 ? -4.97793  -26.41672 -22.54869 1.000 33.62254 ? 419 ASP   A CG  1 
ATOM   1608 O OD1 . ASP   A 1 223 ? -4.10178  -25.93724 -23.30599 1.000 34.07048 ? 419 ASP   A OD1 1 
ATOM   1609 O OD2 . ASP   A 1 223 ? -4.81467  -27.49385 -21.93214 1.000 32.12613 ? 419 ASP   A OD2 1 
ATOM   1610 N N   . ILE   A 1 224 ? -7.44146  -27.95823 -19.77287 1.000 27.99869 ? 420 ILE   A N   1 
ATOM   1611 C CA  . ILE   A 1 224 ? -7.25510  -28.28457 -18.36109 1.000 30.06655 ? 420 ILE   A CA  1 
ATOM   1612 C C   . ILE   A 1 224 ? -5.81401  -28.61586 -18.01111 1.000 29.56969 ? 420 ILE   A C   1 
ATOM   1613 O O   . ILE   A 1 224 ? -5.48529  -28.67023 -16.82628 1.000 26.03776 ? 420 ILE   A O   1 
ATOM   1614 C CB  . ILE   A 1 224 ? -8.19781  -29.42989 -17.91804 1.000 37.42619 ? 420 ILE   A CB  1 
ATOM   1615 C CG1 . ILE   A 1 224 ? -7.56857  -30.80060 -18.19103 1.000 40.31128 ? 420 ILE   A CG1 1 
ATOM   1616 C CG2 . ILE   A 1 224 ? -9.58461  -29.26705 -18.52961 1.000 41.74414 ? 420 ILE   A CG2 1 
ATOM   1617 C CD1 . ILE   A 1 224 ? -8.44155  -31.95775 -17.76098 1.000 45.29080 ? 420 ILE   A CD1 1 
ATOM   1618 N N   . PHE   A 1 225 ? -4.93323  -28.80092 -18.99981 1.000 26.32510 ? 421 PHE   A N   1 
ATOM   1619 C CA  . PHE   A 1 225 ? -3.52680  -29.06847 -18.72804 1.000 29.30412 ? 421 PHE   A CA  1 
ATOM   1620 C C   . PHE   A 1 225 ? -2.63295  -27.86156 -18.97783 1.000 28.03429 ? 421 PHE   A C   1 
ATOM   1621 O O   . PHE   A 1 225 ? -1.40636  -28.01486 -18.98762 1.000 22.14142 ? 421 PHE   A O   1 
ATOM   1622 C CB  . PHE   A 1 225 ? -3.02510  -30.24282 -19.57818 1.000 30.25267 ? 421 PHE   A CB  1 
ATOM   1623 C CG  . PHE   A 1 225 ? -3.47641  -31.58942 -19.08681 1.000 32.10940 ? 421 PHE   A CG  1 
ATOM   1624 C CD1 . PHE   A 1 225 ? -4.22576  -32.41772 -19.90435 1.000 41.44304 ? 421 PHE   A CD1 1 
ATOM   1625 C CD2 . PHE   A 1 225 ? -3.13246  -32.04523 -17.82971 1.000 33.33351 ? 421 PHE   A CD2 1 
ATOM   1626 C CE1 . PHE   A 1 225 ? -4.64734  -33.66744 -19.46231 1.000 40.24123 ? 421 PHE   A CE1 1 
ATOM   1627 C CE2 . PHE   A 1 225 ? -3.55575  -33.29954 -17.38318 1.000 35.92390 ? 421 PHE   A CE2 1 
ATOM   1628 C CZ  . PHE   A 1 225 ? -4.31268  -34.10236 -18.19999 1.000 36.15379 ? 421 PHE   A CZ  1 
ATOM   1629 N N   . LEU   A 1 226 ? -3.20089  -26.66708 -19.18179 1.000 24.44719 ? 422 LEU   A N   1 
ATOM   1630 C CA  . LEU   A 1 226 ? -2.35558  -25.54170 -19.58336 1.000 22.88578 ? 422 LEU   A CA  1 
ATOM   1631 C C   . LEU   A 1 226 ? -1.30324  -25.21144 -18.51987 1.000 19.84368 ? 422 LEU   A C   1 
ATOM   1632 O O   . LEU   A 1 226 ? -0.14821  -24.92128 -18.85179 1.000 20.91427 ? 422 LEU   A O   1 
ATOM   1633 C CB  . LEU   A 1 226 ? -3.21509  -24.31691 -19.92210 1.000 23.76132 ? 422 LEU   A CB  1 
ATOM   1634 C CG  . LEU   A 1 226 ? -2.47214  -23.11531 -20.53586 1.000 21.48707 ? 422 LEU   A CG  1 
ATOM   1635 C CD1 . LEU   A 1 226 ? -1.63969  -23.54201 -21.73433 1.000 20.66168 ? 422 LEU   A CD1 1 
ATOM   1636 C CD2 . LEU   A 1 226 ? -3.43418  -21.99203 -20.92360 1.000 23.94481 ? 422 LEU   A CD2 1 
ATOM   1637 N N   . PHE   A 1 227 ? -1.66852  -25.23935 -17.22690 1.000 23.76945 ? 423 PHE   A N   1 
ATOM   1638 C CA  . PHE   A 1 227 ? -0.66470  -24.93977 -16.20532 1.000 21.22350 ? 423 PHE   A CA  1 
ATOM   1639 C C   . PHE   A 1 227 ? 0.51107   -25.92243 -16.24264 1.000 22.63674 ? 423 PHE   A C   1 
ATOM   1640 O O   . PHE   A 1 227 ? 1.66996   -25.46205 -16.35902 1.000 21.27475 ? 423 PHE   A O   1 
ATOM   1641 C CB  . PHE   A 1 227 ? -1.33791  -24.85840 -14.81953 1.000 21.09174 ? 423 PHE   A CB  1 
ATOM   1642 C CG  . PHE   A 1 227 ? -0.37310  -24.61362 -13.69332 1.000 25.11970 ? 423 PHE   A CG  1 
ATOM   1643 C CD1 . PHE   A 1 227 ? -0.18897  -25.56590 -12.69816 1.000 30.51427 ? 423 PHE   A CD1 1 
ATOM   1644 C CD2 . PHE   A 1 227 ? 0.36372   -23.43662 -13.63007 1.000 28.93736 ? 423 PHE   A CD2 1 
ATOM   1645 C CE1 . PHE   A 1 227 ? 0.69780   -25.34747 -11.65555 1.000 30.46829 ? 423 PHE   A CE1 1 
ATOM   1646 C CE2 . PHE   A 1 227 ? 1.25944   -23.21100 -12.58927 1.000 29.80810 ? 423 PHE   A CE2 1 
ATOM   1647 C CZ  . PHE   A 1 227 ? 1.42695   -24.18073 -11.60301 1.000 29.54365 ? 423 PHE   A CZ  1 
ATOM   1648 N N   . PRO   A 1 228 ? 0.30990   -27.24944 -16.22005 1.000 22.63032 ? 424 PRO   A N   1 
ATOM   1649 C CA  . PRO   A 1 228 ? 1.47758   -28.14678 -16.29138 1.000 20.60449 ? 424 PRO   A CA  1 
ATOM   1650 C C   . PRO   A 1 228 ? 2.21678   -28.06856 -17.63729 1.000 21.52123 ? 424 PRO   A C   1 
ATOM   1651 O O   . PRO   A 1 228 ? 3.44688   -28.21961 -17.66812 1.000 23.39568 ? 424 PRO   A O   1 
ATOM   1652 C CB  . PRO   A 1 228 ? 0.88476   -29.54552 -16.02852 1.000 22.62388 ? 424 PRO   A CB  1 
ATOM   1653 C CG  . PRO   A 1 228 ? -0.61317  -29.39944 -16.16535 1.000 25.79261 ? 424 PRO   A CG  1 
ATOM   1654 C CD  . PRO   A 1 228 ? -0.93526  -27.97609 -15.84917 1.000 22.78986 ? 424 PRO   A CD  1 
ATOM   1655 N N   . LYS   A 1 229 ? 1.51504   -27.76011 -18.73328 1.000 20.86783 ? 425 LYS   A N   1 
ATOM   1656 C CA  . LYS   A 1 229 ? 2.20035   -27.46248 -19.99469 1.000 18.53582 ? 425 LYS   A CA  1 
ATOM   1657 C C   . LYS   A 1 229 ? 3.16711   -26.29663 -19.83440 1.000 22.37614 ? 425 LYS   A C   1 
ATOM   1658 O O   . LYS   A 1 229 ? 4.29992   -26.34044 -20.32800 1.000 22.66480 ? 425 LYS   A O   1 
ATOM   1659 C CB  . LYS   A 1 229 ? 1.18261   -27.11661 -21.08050 1.000 26.16905 ? 425 LYS   A CB  1 
ATOM   1660 C CG  . LYS   A 1 229 ? 0.43462   -28.26836 -21.70827 1.000 30.48224 ? 425 LYS   A CG  1 
ATOM   1661 C CD  . LYS   A 1 229 ? -0.55664  -27.70051 -22.75215 1.000 28.17357 ? 425 LYS   A CD  1 
ATOM   1662 C CE  . LYS   A 1 229 ? -1.63247  -28.67644 -23.17383 1.000 33.50424 ? 425 LYS   A CE  1 
ATOM   1663 N NZ  . LYS   A 1 229 ? -2.49291  -28.02772 -24.22551 1.000 32.80718 ? 425 LYS   A NZ  1 
ATOM   1664 N N   . LEU   A 1 230 ? 2.73676   -25.23219 -19.15523 1.000 20.13737 ? 426 LEU   A N   1 
ATOM   1665 C CA  . LEU   A 1 230 ? 3.60814   -24.06912 -18.99428 1.000 23.10339 ? 426 LEU   A CA  1 
ATOM   1666 C C   . LEU   A 1 230 ? 4.76999   -24.35364 -18.04669 1.000 22.64694 ? 426 LEU   A C   1 
ATOM   1667 O O   . LEU   A 1 230 ? 5.87425   -23.82523 -18.23077 1.000 23.91558 ? 426 LEU   A O   1 
ATOM   1668 C CB  . LEU   A 1 230 ? 2.78966   -22.87800 -18.50151 1.000 18.77474 ? 426 LEU   A CB  1 
ATOM   1669 C CG  . LEU   A 1 230 ? 2.01371   -22.09701 -19.55354 1.000 24.50500 ? 426 LEU   A CG  1 
ATOM   1670 C CD1 . LEU   A 1 230 ? 1.32507   -20.89158 -18.93630 1.000 30.30341 ? 426 LEU   A CD1 1 
ATOM   1671 C CD2 . LEU   A 1 230 ? 2.94884   -21.66246 -20.67432 1.000 26.14914 ? 426 LEU   A CD2 1 
ATOM   1672 N N   . LEU   A 1 231 ? 4.54363   -25.14527 -17.00217 1.000 21.24616 ? 427 LEU   A N   1 
ATOM   1673 C CA  . LEU   A 1 231 ? 5.66752   -25.57268 -16.16406 1.000 21.69527 ? 427 LEU   A CA  1 
ATOM   1674 C C   . LEU   A 1 231 ? 6.72060   -26.28413 -17.00875 1.000 25.91212 ? 427 LEU   A C   1 
ATOM   1675 O O   . LEU   A 1 231 ? 7.92490   -26.02946 -16.87701 1.000 24.12612 ? 427 LEU   A O   1 
ATOM   1676 C CB  . LEU   A 1 231 ? 5.17406   -26.48567 -15.04252 1.000 23.61460 ? 427 LEU   A CB  1 
ATOM   1677 C CG  . LEU   A 1 231 ? 4.24946   -25.80964 -14.00947 1.000 22.97571 ? 427 LEU   A CG  1 
ATOM   1678 C CD1 . LEU   A 1 231 ? 3.78242   -26.83326 -12.96715 1.000 29.63978 ? 427 LEU   A CD1 1 
ATOM   1679 C CD2 . LEU   A 1 231 ? 4.92114   -24.63093 -13.34932 1.000 26.27229 ? 427 LEU   A CD2 1 
ATOM   1680 N N   . GLN   A 1 232 ? 6.27956   -27.14197 -17.92321 1.000 18.92699 ? 428 GLN   A N   1 
ATOM   1681 C CA  . GLN   A 1 232 ? 7.24141   -27.79853 -18.80559 1.000 20.42796 ? 428 GLN   A CA  1 
ATOM   1682 C C   . GLN   A 1 232 ? 7.96903   -26.79330 -19.71134 1.000 22.56909 ? 428 GLN   A C   1 
ATOM   1683 O O   . GLN   A 1 232 ? 9.16660   -26.95902 -20.00243 1.000 25.96789 ? 428 GLN   A O   1 
ATOM   1684 C CB  . GLN   A 1 232 ? 6.53228   -28.86252 -19.63252 1.000 24.05546 ? 428 GLN   A CB  1 
ATOM   1685 C CG  . GLN   A 1 232 ? 7.52184   -29.68482 -20.46845 1.000 25.38677 ? 428 GLN   A CG  1 
ATOM   1686 C CD  . GLN   A 1 232 ? 6.81500   -30.61721 -21.43450 1.000 24.55747 ? 428 GLN   A CD  1 
ATOM   1687 O OE1 . GLN   A 1 232 ? 5.97651   -30.18654 -22.22455 1.000 28.77183 ? 428 GLN   A OE1 1 
ATOM   1688 N NE2 . GLN   A 1 232 ? 7.14905   -31.89616 -21.37275 1.000 32.42518 ? 428 GLN   A NE2 1 
ATOM   1689 N N   . LYS   A 1 233 ? 7.26974   -25.74967 -20.17500 1.000 18.95999 ? 429 LYS   A N   1 
ATOM   1690 C CA  . LYS   A 1 233 ? 7.93458   -24.74296 -21.00514 1.000 21.04621 ? 429 LYS   A CA  1 
ATOM   1691 C C   . LYS   A 1 233 ? 9.00493   -23.97881 -20.23575 1.000 24.19225 ? 429 LYS   A C   1 
ATOM   1692 O O   . LYS   A 1 233 ? 10.00223  -23.55075 -20.84802 1.000 22.06228 ? 429 LYS   A O   1 
ATOM   1693 C CB  . LYS   A 1 233 ? 6.92653   -23.74963 -21.59667 1.000 23.89911 ? 429 LYS   A CB  1 
ATOM   1694 C CG  . LYS   A 1 233 ? 5.87374   -24.35966 -22.52971 1.000 27.24078 ? 429 LYS   A CG  1 
ATOM   1695 C CD  . LYS   A 1 233 ? 6.51113   -25.03613 -23.73714 1.000 30.77703 ? 429 LYS   A CD  1 
ATOM   1696 C CE  . LYS   A 1 233 ? 5.45647   -25.33371 -24.79557 1.000 35.68244 ? 429 LYS   A CE  1 
ATOM   1697 N NZ  . LYS   A 1 233 ? 5.87559   -26.44965 -25.68447 1.000 32.64511 ? 429 LYS   A NZ  1 
ATOM   1698 N N   . MET   A 1 234 ? 8.84553   -23.77053 -18.90841 1.000 20.14169 ? 430 MET   A N   1 
ATOM   1699 C CA  . MET   A 1 234 ? 9.96350   -23.11781 -18.23729 1.000 25.60238 ? 430 MET   A CA  1 
ATOM   1700 C C   . MET   A 1 234 ? 11.17766  -24.03947 -18.14118 1.000 25.47214 ? 430 MET   A C   1 
ATOM   1701 O O   . MET   A 1 234 ? 12.31269  -23.56371 -18.21659 1.000 26.30157 ? 430 MET   A O   1 
ATOM   1702 C CB  . MET   A 1 234 ? 9.62234   -22.51917 -16.85072 1.000 29.20447 ? 430 MET   A CB  1 
ATOM   1703 C CG  . MET   A 1 234 ? 8.25008   -21.86913 -16.63889 1.000 24.13486 ? 430 MET   A CG  1 
ATOM   1704 S SD  . MET   A 1 234 ? 7.65603   -21.86729 -14.89863 1.000 38.34164 ? 430 MET   A SD  1 
ATOM   1705 C CE  . MET   A 1 234 ? 9.04216   -21.00809 -14.14495 1.000 38.57019 ? 430 MET   A CE  1 
ATOM   1706 N N   . ALA   A 1 235 ? 10.96942  -25.34872 -18.03007 1.000 23.54640 ? 431 ALA   A N   1 
ATOM   1707 C CA  . ALA   A 1 235 ? 12.10297  -26.27147 -18.05577 1.000 25.73530 ? 431 ALA   A CA  1 
ATOM   1708 C C   . ALA   A 1 235 ? 12.72823  -26.32294 -19.44675 1.000 27.30793 ? 431 ALA   A C   1 
ATOM   1709 O O   . ALA   A 1 235 ? 13.95527  -26.37391 -19.57573 1.000 28.79894 ? 431 ALA   A O   1 
ATOM   1710 C CB  . ALA   A 1 235 ? 11.67170  -27.66831 -17.60614 1.000 29.54559 ? 431 ALA   A CB  1 
ATOM   1711 N N   . ASP   A 1 236 ? 11.89962  -26.28666 -20.49873 1.000 24.69648 ? 432 ASP   A N   1 
ATOM   1712 C CA  . ASP   A 1 236 ? 12.42934  -26.21982 -21.86379 1.000 25.43447 ? 432 ASP   A CA  1 
ATOM   1713 C C   . ASP   A 1 236 ? 13.25002  -24.95020 -22.07055 1.000 27.57959 ? 432 ASP   A C   1 
ATOM   1714 O O   . ASP   A 1 236 ? 14.30817  -24.97756 -22.71910 1.000 25.34856 ? 432 ASP   A O   1 
ATOM   1715 C CB  . ASP   A 1 236 ? 11.28463  -26.25339 -22.87361 1.000 22.30647 ? 432 ASP   A CB  1 
ATOM   1716 C CG  . ASP   A 1 236 ? 10.53033  -27.58179 -22.90614 1.000 32.24528 ? 432 ASP   A CG  1 
ATOM   1717 O OD1 . ASP   A 1 236 ? 9.45994   -27.59676 -23.55366 1.000 36.25792 ? 432 ASP   A OD1 1 
ATOM   1718 O OD2 . ASP   A 1 236 ? 10.98226  -28.59061 -22.31166 1.000 31.34472 ? 432 ASP   A OD2 1 
ATOM   1719 N N   . LEU   A 1 237 ? 12.76754  -23.81986 -21.53614 1.000 27.44435 ? 433 LEU   A N   1 
ATOM   1720 C CA  . LEU   A 1 237 ? 13.48759  -22.55078 -21.66033 1.000 23.16814 ? 433 LEU   A CA  1 
ATOM   1721 C C   . LEU   A 1 237 ? 14.83949  -22.60150 -20.95790 1.000 25.80806 ? 433 LEU   A C   1 
ATOM   1722 O O   . LEU   A 1 237 ? 15.83519  -22.07560 -21.47202 1.000 22.52400 ? 433 LEU   A O   1 
ATOM   1723 C CB  . LEU   A 1 237 ? 12.64742  -21.39789 -21.08915 1.000 19.40717 ? 433 LEU   A CB  1 
ATOM   1724 C CG  . LEU   A 1 237 ? 11.58936  -20.84416 -22.04574 1.000 20.70340 ? 433 LEU   A CG  1 
ATOM   1725 C CD1 . LEU   A 1 237 ? 10.59233  -19.98759 -21.24642 1.000 21.22789 ? 433 LEU   A CD1 1 
ATOM   1726 C CD2 . LEU   A 1 237 ? 12.24983  -20.04888 -23.23068 1.000 20.46700 ? 433 LEU   A CD2 1 
ATOM   1727 N N   . ARG   A 1 238 ? 14.89991  -23.20163 -19.76257 1.000 21.77881 ? 434 ARG   A N   1 
ATOM   1728 C CA  . ARG   A 1 238 ? 16.19766  -23.33835 -19.10390 1.000 29.76725 ? 434 ARG   A CA  1 
ATOM   1729 C C   . ARG   A 1 238 ? 17.19058  -24.08340 -19.99122 1.000 29.05237 ? 434 ARG   A C   1 
ATOM   1730 O O   . ARG   A 1 238 ? 18.35020  -23.67360 -20.12005 1.000 27.22951 ? 434 ARG   A O   1 
ATOM   1731 C CB  . ARG   A 1 238 ? 16.04060  -24.04746 -17.76148 1.000 31.86813 ? 434 ARG   A CB  1 
ATOM   1732 C CG  . ARG   A 1 238 ? 17.28099  -23.98230 -16.88804 1.000 33.86822 ? 434 ARG   A CG  1 
ATOM   1733 C CD  . ARG   A 1 238 ? 16.99723  -24.67390 -15.57075 1.000 43.20228 ? 434 ARG   A CD  1 
ATOM   1734 N NE  . ARG   A 1 238 ? 15.91823  -24.00376 -14.85393 1.000 37.63134 ? 434 ARG   A NE  1 
ATOM   1735 C CZ  . ARG   A 1 238 ? 15.75223  -24.05809 -13.53885 1.000 48.43672 ? 434 ARG   A CZ  1 
ATOM   1736 N NH1 . ARG   A 1 238 ? 16.57470  -24.75271 -12.76766 1.000 49.18159 ? 434 ARG   A NH1 1 
ATOM   1737 N NH2 . ARG   A 1 238 ? 14.73124  -23.40677 -12.98471 1.000 48.31365 ? 434 ARG   A NH2 1 
ATOM   1738 N N   . GLN   A 1 239 ? 16.74397  -25.15980 -20.64169 1.000 24.95888 ? 435 GLN   A N   1 
ATOM   1739 C CA  . GLN   A 1 239 ? 17.63883  -25.92432 -21.50360 1.000 26.05477 ? 435 GLN   A CA  1 
ATOM   1740 C C   . GLN   A 1 239 ? 17.97371  -25.15346 -22.77367 1.000 28.47343 ? 435 GLN   A C   1 
ATOM   1741 O O   . GLN   A 1 239 ? 19.10801  -25.22158 -23.27492 1.000 32.21041 ? 435 GLN   A O   1 
ATOM   1742 C CB  . GLN   A 1 239 ? 17.00144  -27.26655 -21.84620 1.000 28.24546 ? 435 GLN   A CB  1 
ATOM   1743 C CG  . GLN   A 1 239 ? 17.89196  -28.15670 -22.68323 1.000 34.24359 ? 435 GLN   A CG  1 
ATOM   1744 C CD  . GLN   A 1 239 ? 19.11056  -28.61232 -21.90894 1.000 41.66539 ? 435 GLN   A CD  1 
ATOM   1745 O OE1 . GLN   A 1 239 ? 19.07979  -28.69462 -20.67628 1.000 43.14865 ? 435 GLN   A OE1 1 
ATOM   1746 N NE2 . GLN   A 1 239 ? 20.19024  -28.91252 -22.62046 1.000 42.53332 ? 435 GLN   A NE2 1 
ATOM   1747 N N   . LEU   A 1 240 ? 16.99920  -24.42373 -23.31921 1.000 21.59604 ? 436 LEU   A N   1 
ATOM   1748 C CA  . LEU   A 1 240 ? 17.26171  -23.59708 -24.49040 1.000 25.79903 ? 436 LEU   A CA  1 
ATOM   1749 C C   . LEU   A 1 240 ? 18.32577  -22.54793 -24.19686 1.000 25.42301 ? 436 LEU   A C   1 
ATOM   1750 O O   . LEU   A 1 240 ? 19.18187  -22.26195 -25.04585 1.000 26.49082 ? 436 LEU   A O   1 
ATOM   1751 C CB  . LEU   A 1 240 ? 15.96316  -22.92437 -24.95317 1.000 21.04142 ? 436 LEU   A CB  1 
ATOM   1752 C CG  . LEU   A 1 240 ? 15.87195  -22.25610 -26.31953 1.000 30.72971 ? 436 LEU   A CG  1 
ATOM   1753 C CD1 . LEU   A 1 240 ? 15.87045  -23.29870 -27.43310 1.000 31.82852 ? 436 LEU   A CD1 1 
ATOM   1754 C CD2 . LEU   A 1 240 ? 14.59672  -21.39878 -26.36775 1.000 30.07886 ? 436 LEU   A CD2 1 
ATOM   1755 N N   . VAL   A 1 241 ? 18.27732  -21.94934 -23.00514 1.000 24.75534 ? 437 VAL   A N   1 
ATOM   1756 C CA  . VAL   A 1 241 ? 19.24382  -20.90973 -22.66680 1.000 25.77638 ? 437 VAL   A CA  1 
ATOM   1757 C C   . VAL   A 1 241 ? 20.62965  -21.52663 -22.45647 1.000 29.15019 ? 437 VAL   A C   1 
ATOM   1758 O O   . VAL   A 1 241 ? 21.64160  -20.97136 -22.90336 1.000 27.86825 ? 437 VAL   A O   1 
ATOM   1759 C CB  . VAL   A 1 241 ? 18.76020  -20.12238 -21.43045 1.000 27.12548 ? 437 VAL   A CB  1 
ATOM   1760 C CG1 . VAL   A 1 241 ? 19.87854  -19.26298 -20.82414 1.000 29.55136 ? 437 VAL   A CG1 1 
ATOM   1761 C CG2 . VAL   A 1 241 ? 17.53028  -19.22618 -21.77903 1.000 23.61891 ? 437 VAL   A CG2 1 
ATOM   1762 N N   . THR   A 1 242 ? 20.69920  -22.68507 -21.78113 1.000 28.72574 ? 438 THR   A N   1 
ATOM   1763 C CA  . THR   A 1 242 ? 21.99096  -23.35228 -21.58757 1.000 31.62369 ? 438 THR   A CA  1 
ATOM   1764 C C   . THR   A 1 242 ? 22.67739  -23.60777 -22.91966 1.000 32.92275 ? 438 THR   A C   1 
ATOM   1765 O O   . THR   A 1 242 ? 23.86712  -23.30859 -23.09601 1.000 30.79680 ? 438 THR   A O   1 
ATOM   1766 C CB  . THR   A 1 242 ? 21.80780  -24.68082 -20.84609 1.000 35.83710 ? 438 THR   A CB  1 
ATOM   1767 O OG1 . THR   A 1 242 ? 21.10784  -24.46615 -19.61659 1.000 32.11069 ? 438 THR   A OG1 1 
ATOM   1768 C CG2 . THR   A 1 242 ? 23.16100  -25.30144 -20.54214 1.000 36.50041 ? 438 THR   A CG2 1 
ATOM   1769 N N   . GLU   A 1 243 ? 21.93873  -24.17924 -23.87006 1.000 25.67990 ? 439 GLU   A N   1 
ATOM   1770 C CA  . GLU   A 1 243 ? 22.49198  -24.42267 -25.19335 1.000 30.69944 ? 439 GLU   A CA  1 
ATOM   1771 C C   . GLU   A 1 243 ? 22.84164  -23.12919 -25.91148 1.000 33.94410 ? 439 GLU   A C   1 
ATOM   1772 O O   . GLU   A 1 243 ? 23.81295  -23.09584 -26.67657 1.000 29.68091 ? 439 GLU   A O   1 
ATOM   1773 C CB  . GLU   A 1 243 ? 21.50413  -25.24274 -26.01048 1.000 27.27864 ? 439 GLU   A CB  1 
ATOM   1774 C CG  . GLU   A 1 243 ? 21.26246  -26.59346 -25.37032 1.000 33.77550 ? 439 GLU   A CG  1 
ATOM   1775 C CD  . GLU   A 1 243 ? 20.07231  -27.31256 -25.93928 1.000 39.99527 ? 439 GLU   A CD  1 
ATOM   1776 O OE1 . GLU   A 1 243 ? 19.35966  -26.72457 -26.78973 1.000 43.41296 ? 439 GLU   A OE1 1 
ATOM   1777 O OE2 . GLU   A 1 243 ? 19.85453  -28.47109 -25.53258 1.000 44.29999 ? 439 GLU   A OE2 1 
ATOM   1778 N N   . HIS   A 1 244 ? 22.05650  -22.06319 -25.69679 1.000 26.36407 ? 440 HIS   A N   1 
ATOM   1779 C CA  . HIS   A 1 244 ? 22.37636  -20.78193 -26.31856 1.000 23.44876 ? 440 HIS   A CA  1 
ATOM   1780 C C   . HIS   A 1 244 ? 23.69052  -20.23039 -25.77375 1.000 27.12300 ? 440 HIS   A C   1 
ATOM   1781 O O   . HIS   A 1 244 ? 24.53020  -19.73982 -26.54157 1.000 26.41239 ? 440 HIS   A O   1 
ATOM   1782 C CB  . HIS   A 1 244 ? 21.23833  -19.78713 -26.08553 1.000 25.64448 ? 440 HIS   A CB  1 
ATOM   1783 C CG  . HIS   A 1 244 ? 21.44431  -18.45667 -26.73395 1.000 22.08371 ? 440 HIS   A CG  1 
ATOM   1784 N ND1 . HIS   A 1 244 ? 21.25633  -18.24027 -28.07968 1.000 22.44568 ? 440 HIS   A ND1 1 
ATOM   1785 C CD2 . HIS   A 1 244 ? 21.80541  -17.26326 -26.20991 1.000 22.90595 ? 440 HIS   A CD2 1 
ATOM   1786 C CE1 . HIS   A 1 244 ? 21.48804  -16.97229 -28.35992 1.000 22.67486 ? 440 HIS   A CE1 1 
ATOM   1787 N NE2 . HIS   A 1 244 ? 21.81401  -16.35641 -27.23873 1.000 20.73804 ? 440 HIS   A NE2 1 
ATOM   1788 N N   . ALA   A 1 245 ? 23.90315  -20.33957 -24.45830 1.000 27.52744 ? 441 ALA   A N   1 
ATOM   1789 C CA  . ALA   A 1 245 ? 25.15124  -19.85681 -23.87102 1.000 32.21284 ? 441 ALA   A CA  1 
ATOM   1790 C C   . ALA   A 1 245 ? 26.35694  -20.63463 -24.39773 1.000 33.05534 ? 441 ALA   A C   1 
ATOM   1791 O O   . ALA   A 1 245 ? 27.46235  -20.08216 -24.47674 1.000 35.45649 ? 441 ALA   A O   1 
ATOM   1792 C CB  . ALA   A 1 245 ? 25.09518  -19.92561 -22.34517 1.000 32.62555 ? 441 ALA   A CB  1 
ATOM   1793 N N   . GLN   A 1 246 ? 26.16619  -21.89620 -24.79315 1.000 28.33598 ? 442 GLN   A N   1 
ATOM   1794 C CA  . GLN   A 1 246 ? 27.27985  -22.62463 -25.39594 1.000 35.34575 ? 442 GLN   A CA  1 
ATOM   1795 C C   . GLN   A 1 246 ? 27.61627  -22.06656 -26.77303 1.000 38.61491 ? 442 GLN   A C   1 
ATOM   1796 O O   . GLN   A 1 246 ? 28.79663  -22.01582 -27.14864 1.000 33.10696 ? 442 GLN   A O   1 
ATOM   1797 C CB  . GLN   A 1 246 ? 26.96793  -24.12358 -25.45988 1.000 32.01639 ? 442 GLN   A CB  1 
ATOM   1798 C CG  . GLN   A 1 246 ? 27.12669  -24.80901 -24.09463 1.000 36.72736 ? 442 GLN   A CG  1 
ATOM   1799 C CD  . GLN   A 1 246 ? 26.29138  -26.06821 -23.93711 1.000 41.84049 ? 442 GLN   A CD  1 
ATOM   1800 O OE1 . GLN   A 1 246 ? 25.69379  -26.56057 -24.89394 1.000 43.75464 ? 442 GLN   A OE1 1 
ATOM   1801 N NE2 . GLN   A 1 246 ? 26.23327  -26.58549 -22.71517 1.000 49.13001 ? 442 GLN   A NE2 1 
ATOM   1802 N N   . LEU   A 1 247 ? 26.60550  -21.61106 -27.52163 1.000 32.90779 ? 443 LEU   A N   1 
ATOM   1803 C CA  . LEU   A 1 247 ? 26.86100  -20.93362 -28.78908 1.000 33.47162 ? 443 LEU   A CA  1 
ATOM   1804 C C   . LEU   A 1 247 ? 27.56246  -19.60041 -28.57479 1.000 33.71296 ? 443 LEU   A C   1 
ATOM   1805 O O   . LEU   A 1 247 ? 28.44559  -19.22725 -29.35902 1.000 38.05589 ? 443 LEU   A O   1 
ATOM   1806 C CB  . LEU   A 1 247 ? 25.55532  -20.72018 -29.55262 1.000 29.58456 ? 443 LEU   A CB  1 
ATOM   1807 C CG  . LEU   A 1 247 ? 24.84099  -21.90184 -30.19018 1.000 41.22536 ? 443 LEU   A CG  1 
ATOM   1808 C CD1 . LEU   A 1 247 ? 23.42607  -21.48357 -30.57194 1.000 39.45218 ? 443 LEU   A CD1 1 
ATOM   1809 C CD2 . LEU   A 1 247 ? 25.59574  -22.37297 -31.42031 1.000 47.10072 ? 443 LEU   A CD2 1 
ATOM   1810 N N   . VAL   A 1 248 ? 27.16509  -18.85666 -27.53654 1.000 30.87988 ? 444 VAL   A N   1 
ATOM   1811 C CA  . VAL   A 1 248 ? 27.83870  -17.60148 -27.20823 1.000 33.75223 ? 444 VAL   A CA  1 
ATOM   1812 C C   . VAL   A 1 248 ? 29.33173  -17.84164 -27.01330 1.000 37.80819 ? 444 VAL   A C   1 
ATOM   1813 O O   . VAL   A 1 248 ? 30.17185  -17.05648 -27.47391 1.000 36.49924 ? 444 VAL   A O   1 
ATOM   1814 C CB  . VAL   A 1 248 ? 27.20786  -16.95817 -25.96039 1.000 32.28549 ? 444 VAL   A CB  1 
ATOM   1815 C CG1 . VAL   A 1 248 ? 28.02706  -15.74667 -25.48791 1.000 30.84319 ? 444 VAL   A CG1 1 
ATOM   1816 C CG2 . VAL   A 1 248 ? 25.76464  -16.54572 -26.25054 1.000 31.52254 ? 444 VAL   A CG2 1 
ATOM   1817 N N   . GLN   A 1 249 ? 29.68103  -18.94202 -26.34661 1.000 33.03289 ? 445 GLN   A N   1 
ATOM   1818 C CA  . GLN   A 1 249 ? 31.08583  -19.21753 -26.06815 1.000 38.34585 ? 445 GLN   A CA  1 
ATOM   1819 C C   . GLN   A 1 249 ? 31.82682  -19.67058 -27.32249 1.000 41.99867 ? 445 GLN   A C   1 
ATOM   1820 O O   . GLN   A 1 249 ? 32.99569  -19.31375 -27.51210 1.000 40.41612 ? 445 GLN   A O   1 
ATOM   1821 C CB  . GLN   A 1 249 ? 31.19937  -20.24802 -24.94451 1.000 41.15837 ? 445 GLN   A CB  1 
ATOM   1822 C CG  . GLN   A 1 249 ? 32.61578  -20.75014 -24.72878 1.000 40.60082 ? 445 GLN   A CG  1 
ATOM   1823 C CD  . GLN   A 1 249 ? 33.50868  -19.74104 -24.03005 1.000 42.83868 ? 445 GLN   A CD  1 
ATOM   1824 O OE1 . GLN   A 1 249 ? 33.04837  -18.70606 -23.53421 1.000 47.44551 ? 445 GLN   A OE1 1 
ATOM   1825 N NE2 . GLN   A 1 249 ? 34.81260  -20.02848 -24.01466 1.000 39.34836 ? 445 GLN   A NE2 1 
ATOM   1826 N N   . ILE   A 1 250 ? 31.16711  -20.44572 -28.19579 1.000 36.40408 ? 446 ILE   A N   1 
ATOM   1827 C CA  . ILE   A 1 250 ? 31.78750  -20.85421 -29.46097 1.000 40.61500 ? 446 ILE   A CA  1 
ATOM   1828 C C   . ILE   A 1 250 ? 32.09475  -19.63480 -30.32101 1.000 44.30741 ? 446 ILE   A C   1 
ATOM   1829 O O   . ILE   A 1 250 ? 33.12320  -19.57905 -31.01204 1.000 43.66817 ? 446 ILE   A O   1 
ATOM   1830 C CB  . ILE   A 1 250 ? 30.88348  -21.84641 -30.21840 1.000 40.12460 ? 446 ILE   A CB  1 
ATOM   1831 C CG1 . ILE   A 1 250 ? 31.11328  -23.27498 -29.73396 1.000 44.78487 ? 446 ILE   A CG1 1 
ATOM   1832 C CG2 . ILE   A 1 250 ? 31.15245  -21.78728 -31.71701 1.000 44.05361 ? 446 ILE   A CG2 1 
ATOM   1833 C CD1 . ILE   A 1 250 ? 29.86843  -24.11704 -29.76307 1.000 46.88574 ? 446 ILE   A CD1 1 
ATOM   1834 N N   . ILE   A 1 251 ? 31.21398  -18.63605 -30.29012 1.000 38.52517 ? 447 ILE   A N   1 
ATOM   1835 C CA  . ILE   A 1 251 ? 31.44011  -17.42444 -31.07215 1.000 40.68564 ? 447 ILE   A CA  1 
ATOM   1836 C C   . ILE   A 1 251 ? 32.54832  -16.58702 -30.45014 1.000 45.44918 ? 447 ILE   A C   1 
ATOM   1837 O O   . ILE   A 1 251 ? 33.44910  -16.10636 -31.14898 1.000 45.81137 ? 447 ILE   A O   1 
ATOM   1838 C CB  . ILE   A 1 251 ? 30.13372  -16.62001 -31.20960 1.000 37.18169 ? 447 ILE   A CB  1 
ATOM   1839 C CG1 . ILE   A 1 251 ? 29.31122  -17.14191 -32.38579 1.000 38.56916 ? 447 ILE   A CG1 1 
ATOM   1840 C CG2 . ILE   A 1 251 ? 30.42133  -15.13758 -31.35962 1.000 42.43591 ? 447 ILE   A CG2 1 
ATOM   1841 C CD1 . ILE   A 1 251 ? 27.84931  -16.76345 -32.32313 1.000 38.71056 ? 447 ILE   A CD1 1 
ATOM   1842 N N   . LYS   A 1 252 ? 32.50352  -16.40532 -29.12740 1.000 38.18053 ? 448 LYS   A N   1 
ATOM   1843 C CA  . LYS   A 1 252 ? 33.43754  -15.49597 -28.46754 1.000 46.65578 ? 448 LYS   A CA  1 
ATOM   1844 C C   . LYS   A 1 252 ? 34.88441  -15.93173 -28.66416 1.000 54.30800 ? 448 LYS   A C   1 
ATOM   1845 O O   . LYS   A 1 252 ? 35.78466  -15.08730 -28.76698 1.000 54.74410 ? 448 LYS   A O   1 
ATOM   1846 C CB  . LYS   A 1 252 ? 33.10747  -15.40134 -26.97886 1.000 50.62870 ? 448 LYS   A CB  1 
ATOM   1847 C CG  . LYS   A 1 252 ? 34.09063  -14.57833 -26.16549 1.000 53.21379 ? 448 LYS   A CG  1 
ATOM   1848 C CD  . LYS   A 1 252 ? 33.73197  -14.57904 -24.69086 1.000 53.94579 ? 448 LYS   A CD  1 
ATOM   1849 C CE  . LYS   A 1 252 ? 34.91924  -15.01725 -23.83996 1.000 55.45597 ? 448 LYS   A CE  1 
ATOM   1850 N NZ  . LYS   A 1 252 ? 35.12400  -14.08298 -22.68814 1.000 52.90866 ? 448 LYS   A NZ  1 
ATOM   1851 N N   . LYS   A 1 253 ? 35.12397  -17.23521 -28.75773 1.000 49.03786 ? 449 LYS   A N   1 
ATOM   1852 C CA  . LYS   A 1 253 ? 36.48187  -17.73375 -28.85085 1.000 51.56070 ? 449 LYS   A CA  1 
ATOM   1853 C C   . LYS   A 1 253 ? 36.94450  -17.99923 -30.27802 1.000 57.05564 ? 449 LYS   A C   1 
ATOM   1854 O O   . LYS   A 1 253 ? 38.15822  -18.06184 -30.50742 1.000 55.90838 ? 449 LYS   A O   1 
ATOM   1855 C CB  . LYS   A 1 253 ? 36.63242  -19.01233 -28.01594 1.000 52.47465 ? 449 LYS   A CB  1 
ATOM   1856 C CG  . LYS   A 1 253 ? 36.39495  -20.30699 -28.78025 1.000 56.75445 ? 449 LYS   A CG  1 
ATOM   1857 C CD  . LYS   A 1 253 ? 36.31902  -21.48434 -27.82340 1.000 51.72756 ? 449 LYS   A CD  1 
ATOM   1858 C CE  . LYS   A 1 253 ? 37.57971  -22.32278 -27.92909 1.000 49.18948 ? 449 LYS   A CE  1 
ATOM   1859 N NZ  . LYS   A 1 253 ? 37.75939  -23.23142 -26.76565 1.000 56.35044 ? 449 LYS   A NZ  1 
ATOM   1860 N N   . THR   A 1 254 ? 36.03196  -18.15349 -31.24273 1.000 47.67915 ? 450 THR   A N   1 
ATOM   1861 C CA  . THR   A 1 254 ? 36.43243  -18.38957 -32.62669 1.000 55.48767 ? 450 THR   A CA  1 
ATOM   1862 C C   . THR   A 1 254 ? 36.20897  -17.20617 -33.55310 1.000 55.20701 ? 450 THR   A C   1 
ATOM   1863 O O   . THR   A 1 254 ? 36.97553  -17.03758 -34.50364 1.000 58.83802 ? 450 THR   A O   1 
ATOM   1864 C CB  . THR   A 1 254 ? 35.70279  -19.60624 -33.21995 1.000 50.35211 ? 450 THR   A CB  1 
ATOM   1865 O OG1 . THR   A 1 254 ? 34.33546  -19.27091 -33.50377 1.000 55.09531 ? 450 THR   A OG1 1 
ATOM   1866 C CG2 . THR   A 1 254 ? 35.76793  -20.79507 -32.28110 1.000 53.72729 ? 450 THR   A CG2 1 
ATOM   1867 N N   . GLU   A 1 255 ? 35.19220  -16.38365 -33.31620 1.000 52.96417 ? 451 GLU   A N   1 
ATOM   1868 C CA  . GLU   A 1 255 ? 34.87445  -15.32097 -34.25953 1.000 52.62933 ? 451 GLU   A CA  1 
ATOM   1869 C C   . GLU   A 1 255 ? 35.76738  -14.11446 -34.00507 1.000 58.28501 ? 451 GLU   A C   1 
ATOM   1870 O O   . GLU   A 1 255 ? 35.80762  -13.57725 -32.89237 1.000 62.00531 ? 451 GLU   A O   1 
ATOM   1871 C CB  . GLU   A 1 255 ? 33.39629  -14.94941 -34.18768 1.000 50.62922 ? 451 GLU   A CB  1 
ATOM   1872 C CG  . GLU   A 1 255 ? 32.49934  -16.06309 -34.69079 1.000 45.26819 ? 451 GLU   A CG  1 
ATOM   1873 C CD  . GLU   A 1 255 ? 32.67263  -16.31411 -36.17565 1.000 46.73446 ? 451 GLU   A CD  1 
ATOM   1874 O OE1 . GLU   A 1 255 ? 33.01538  -15.35783 -36.91027 1.000 47.63767 ? 451 GLU   A OE1 1 
ATOM   1875 O OE2 . GLU   A 1 255 ? 32.46913  -17.47116 -36.61603 1.000 43.36335 ? 451 GLU   A OE2 1 
ATOM   1876 N N   . SER   A 1 256 ? 36.47458  -13.69265 -35.05691 1.000 61.01531 ? 452 SER   A N   1 
ATOM   1877 C CA  . SER   A 1 256 ? 37.48010  -12.64236 -34.93456 1.000 62.94550 ? 452 SER   A CA  1 
ATOM   1878 C C   . SER   A 1 256 ? 36.86747  -11.32811 -34.46315 1.000 58.24830 ? 452 SER   A C   1 
ATOM   1879 O O   . SER   A 1 256 ? 37.43242  -10.64499 -33.59915 1.000 61.77707 ? 452 SER   A O   1 
ATOM   1880 C CB  . SER   A 1 256 ? 38.17568  -12.45292 -36.28465 1.000 64.51882 ? 452 SER   A CB  1 
ATOM   1881 O OG  . SER   A 1 256 ? 38.91364  -13.61061 -36.64664 1.000 59.78742 ? 452 SER   A OG  1 
ATOM   1882 N N   . ASP   A 1 257 ? 35.70108  -10.96999 -35.00616 1.000 52.88656 ? 453 ASP   A N   1 
ATOM   1883 C CA  . ASP   A 1 257 ? 35.11491  -9.64373  -34.84807 1.000 53.82177 ? 453 ASP   A CA  1 
ATOM   1884 C C   . ASP   A 1 257 ? 33.81703  -9.64476  -34.05009 1.000 54.06156 ? 453 ASP   A C   1 
ATOM   1885 O O   . ASP   A 1 257 ? 33.01720  -8.71136  -34.17905 1.000 52.39978 ? 453 ASP   A O   1 
ATOM   1886 C CB  . ASP   A 1 257 ? 34.85578  -9.02025  -36.21687 1.000 52.20346 ? 453 ASP   A CB  1 
ATOM   1887 C CG  . ASP   A 1 257 ? 35.37911  -7.61489  -36.31763 1.000 63.34736 ? 453 ASP   A CG  1 
ATOM   1888 O OD1 . ASP   A 1 257 ? 36.06071  -7.31228  -37.31788 1.000 72.06751 ? 453 ASP   A OD1 1 
ATOM   1889 O OD2 . ASP   A 1 257 ? 35.11740  -6.81823  -35.38961 1.000 63.37831 ? 453 ASP   A OD2 1 
ATOM   1890 N N   . ALA   A 1 258 ? 33.57909  -10.66513 -33.23517 1.000 51.17249 ? 454 ALA   A N   1 
ATOM   1891 C CA  . ALA   A 1 258 ? 32.32769  -10.75509 -32.49319 1.000 50.86114 ? 454 ALA   A CA  1 
ATOM   1892 C C   . ALA   A 1 258 ? 32.59120  -10.38365 -31.03696 1.000 47.13398 ? 454 ALA   A C   1 
ATOM   1893 O O   . ALA   A 1 258 ? 32.69055  -11.23478 -30.15426 1.000 49.92139 ? 454 ALA   A O   1 
ATOM   1894 C CB  . ALA   A 1 258 ? 31.72741  -12.14687 -32.63098 1.000 54.65506 ? 454 ALA   A CB  1 
ATOM   1895 N N   . ALA   A 1 259 ? 32.68862  -9.07728  -30.79063 1.000 44.32828 ? 455 ALA   A N   1 
ATOM   1896 C CA  . ALA   A 1 259 ? 32.90134  -8.56484  -29.44207 1.000 42.58606 ? 455 ALA   A CA  1 
ATOM   1897 C C   . ALA   A 1 259 ? 31.59412  -8.56485  -28.64854 1.000 40.34332 ? 455 ALA   A C   1 
ATOM   1898 O O   . ALA   A 1 259 ? 30.57259  -8.05266  -29.11650 1.000 39.05146 ? 455 ALA   A O   1 
ATOM   1899 C CB  . ALA   A 1 259 ? 33.47435  -7.15010  -29.50126 1.000 41.00606 ? 455 ALA   A CB  1 
ATOM   1900 N N   . LEU   A 1 260 ? 31.63426  -9.11530  -27.43968 1.000 37.14702 ? 456 LEU   A N   1 
ATOM   1901 C CA  . LEU   A 1 260 ? 30.45578  -9.13743  -26.58659 1.000 38.51022 ? 456 LEU   A CA  1 
ATOM   1902 C C   . LEU   A 1 260 ? 30.24172  -7.79258  -25.90649 1.000 39.20010 ? 456 LEU   A C   1 
ATOM   1903 O O   . LEU   A 1 260 ? 31.18267  -7.17890  -25.39733 1.000 37.25036 ? 456 LEU   A O   1 
ATOM   1904 C CB  . LEU   A 1 260 ? 30.58301  -10.21518 -25.51481 1.000 38.08337 ? 456 LEU   A CB  1 
ATOM   1905 C CG  . LEU   A 1 260 ? 30.28606  -11.64703 -25.93689 1.000 47.95434 ? 456 LEU   A CG  1 
ATOM   1906 C CD1 . LEU   A 1 260 ? 30.10482  -12.53581 -24.69524 1.000 44.33443 ? 456 LEU   A CD1 1 
ATOM   1907 C CD2 . LEU   A 1 260 ? 29.08087  -11.69179 -26.85801 1.000 44.92585 ? 456 LEU   A CD2 1 
ATOM   1908 N N   . HIS   A 1 261 ? 28.99395  -7.34543  -25.88719 1.000 32.12923 ? 457 HIS   A N   1 
ATOM   1909 C CA  . HIS   A 1 261 ? 28.63476  -6.19918  -25.07260 1.000 28.49137 ? 457 HIS   A CA  1 
ATOM   1910 C C   . HIS   A 1 261 ? 28.93482  -6.50408  -23.60649 1.000 34.29608 ? 457 HIS   A C   1 
ATOM   1911 O O   . HIS   A 1 261 ? 28.65961  -7.61510  -23.13902 1.000 32.15175 ? 457 HIS   A O   1 
ATOM   1912 C CB  . HIS   A 1 261 ? 27.14977  -5.87044  -25.25595 1.000 31.13719 ? 457 HIS   A CB  1 
ATOM   1913 C CG  . HIS   A 1 261 ? 26.70519  -4.60282  -24.58903 1.000 32.06691 ? 457 HIS   A CG  1 
ATOM   1914 N ND1 . HIS   A 1 261 ? 26.55421  -4.48743  -23.22265 1.000 30.92621 ? 457 HIS   A ND1 1 
ATOM   1915 C CD2 . HIS   A 1 261 ? 26.33631  -3.40601  -25.10798 1.000 37.68136 ? 457 HIS   A CD2 1 
ATOM   1916 C CE1 . HIS   A 1 261 ? 26.12298  -3.27376  -22.92744 1.000 31.03910 ? 457 HIS   A CE1 1 
ATOM   1917 N NE2 . HIS   A 1 261 ? 25.98192  -2.59734  -24.05435 1.000 33.12532 ? 457 HIS   A NE2 1 
ATOM   1918 N N   . PRO   A 1 262 ? 29.48040  -5.54187  -22.85086 1.000 38.03679 ? 458 PRO   A N   1 
ATOM   1919 C CA  . PRO   A 1 262 ? 29.87771  -5.83325  -21.45672 1.000 38.32909 ? 458 PRO   A CA  1 
ATOM   1920 C C   . PRO   A 1 262 ? 28.74374  -6.29097  -20.54995 1.000 32.91317 ? 458 PRO   A C   1 
ATOM   1921 O O   . PRO   A 1 262 ? 28.97108  -7.12614  -19.66602 1.000 33.03803 ? 458 PRO   A O   1 
ATOM   1922 C CB  . PRO   A 1 262 ? 30.46561  -4.49610  -20.97199 1.000 42.31387 ? 458 PRO   A CB  1 
ATOM   1923 C CG  . PRO   A 1 262 ? 30.85704  -3.77014  -22.21799 1.000 45.00042 ? 458 PRO   A CG  1 
ATOM   1924 C CD  . PRO   A 1 262 ? 29.88140  -4.18833  -23.28068 1.000 40.90211 ? 458 PRO   A CD  1 
ATOM   1925 N N   . LEU   A 1 263 ? 27.53729  -5.74092  -20.69433 1.000 34.15461 ? 459 LEU   A N   1 
ATOM   1926 C CA  . LEU   A 1 263 ? 26.43593  -6.22407  -19.86554 1.000 34.20088 ? 459 LEU   A CA  1 
ATOM   1927 C C   . LEU   A 1 263 ? 26.13484  -7.68846  -20.16101 1.000 32.59748 ? 459 LEU   A C   1 
ATOM   1928 O O   . LEU   A 1 263 ? 25.95379  -8.49336  -19.23924 1.000 29.86266 ? 459 LEU   A O   1 
ATOM   1929 C CB  . LEU   A 1 263 ? 25.19818  -5.35286  -20.06840 1.000 30.30090 ? 459 LEU   A CB  1 
ATOM   1930 C CG  . LEU   A 1 263 ? 23.91843  -5.83745  -19.38242 1.000 32.03787 ? 459 LEU   A CG  1 
ATOM   1931 C CD1 . LEU   A 1 263 ? 24.06520  -5.81659  -17.87037 1.000 30.94369 ? 459 LEU   A CD1 1 
ATOM   1932 C CD2 . LEU   A 1 263 ? 22.75341  -4.97267  -19.78487 1.000 27.77517 ? 459 LEU   A CD2 1 
ATOM   1933 N N   . LEU   A 1 264 ? 26.09690  -8.06118  -21.44218 1.000 25.30974 ? 460 LEU   A N   1 
ATOM   1934 C CA  . LEU   A 1 264 ? 25.80841  -9.44674  -21.77909 1.000 27.52646 ? 460 LEU   A CA  1 
ATOM   1935 C C   . LEU   A 1 264 ? 26.95705  -10.35978 -21.36906 1.000 33.98441 ? 460 LEU   A C   1 
ATOM   1936 O O   . LEU   A 1 264 ? 26.73140  -11.50202 -20.95190 1.000 29.99406 ? 460 LEU   A O   1 
ATOM   1937 C CB  . LEU   A 1 264 ? 25.50515  -9.56740  -23.27780 1.000 24.68833 ? 460 LEU   A CB  1 
ATOM   1938 C CG  . LEU   A 1 264 ? 24.40508  -8.64787  -23.81979 1.000 25.75243 ? 460 LEU   A CG  1 
ATOM   1939 C CD1 . LEU   A 1 264 ? 24.13271  -8.91226  -25.29968 1.000 29.82556 ? 460 LEU   A CD1 1 
ATOM   1940 C CD2 . LEU   A 1 264 ? 23.10730  -8.79160  -23.00879 1.000 27.19666 ? 460 LEU   A CD2 1 
ATOM   1941 N N   . GLN   A 1 265 ? 28.18998  -9.86321  -21.44322 1.000 30.21074 ? 461 GLN   A N   1 
ATOM   1942 C CA  . GLN   A 1 265 ? 29.31675  -10.62003 -20.90324 1.000 32.88131 ? 461 GLN   A CA  1 
ATOM   1943 C C   . GLN   A 1 265 ? 29.13886  -10.89472 -19.41303 1.000 26.07219 ? 461 GLN   A C   1 
ATOM   1944 O O   . GLN   A 1 265 ? 29.38892  -12.01161 -18.94866 1.000 33.51558 ? 461 GLN   A O   1 
ATOM   1945 C CB  . GLN   A 1 265 ? 30.61567  -9.86194  -21.17211 1.000 35.44221 ? 461 GLN   A CB  1 
ATOM   1946 C CG  . GLN   A 1 265 ? 31.86985  -10.54362 -20.65608 1.000 39.04447 ? 461 GLN   A CG  1 
ATOM   1947 C CD  . GLN   A 1 265 ? 32.18257  -11.81309 -21.42324 1.000 52.71425 ? 461 GLN   A CD  1 
ATOM   1948 O OE1 . GLN   A 1 265 ? 33.05665  -11.83227 -22.29514 1.000 52.68785 ? 461 GLN   A OE1 1 
ATOM   1949 N NE2 . GLN   A 1 265 ? 31.50982  -12.90718 -21.05207 1.000 52.41743 ? 461 GLN   A NE2 1 
ATOM   1950 N N   . GLU   A 1 266 ? 28.69051  -9.88865  -18.65698 1.000 29.07364 ? 462 GLU   A N   1 
ATOM   1951 C CA  . GLU   A 1 266 ? 28.41498  -10.07481 -17.23467 1.000 32.80898 ? 462 GLU   A CA  1 
ATOM   1952 C C   . GLU   A 1 266 ? 27.32762  -11.12077 -17.00803 1.000 35.26918 ? 462 GLU   A C   1 
ATOM   1953 O O   . GLU   A 1 266 ? 27.43511  -11.96267 -16.10076 1.000 30.79757 ? 462 GLU   A O   1 
ATOM   1954 C CB  . GLU   A 1 266 ? 28.01669  -8.73727  -16.61818 1.000 33.77183 ? 462 GLU   A CB  1 
ATOM   1955 C CG  . GLU   A 1 266 ? 27.61449  -8.81041  -15.15638 1.000 40.34840 ? 462 GLU   A CG  1 
ATOM   1956 C CD  . GLU   A 1 266 ? 27.35662  -7.43503  -14.56261 1.000 44.70512 ? 462 GLU   A CD  1 
ATOM   1957 O OE1 . GLU   A 1 266 ? 28.19565  -6.53024  -14.78760 1.000 50.57587 ? 462 GLU   A OE1 1 
ATOM   1958 O OE2 . GLU   A 1 266 ? 26.32869  -7.26277  -13.86504 1.000 46.20635 ? 462 GLU   A OE2 1 
ATOM   1959 N N   . ILE   A 1 267 ? 26.28109  -11.09938 -17.83815 1.000 31.75693 ? 463 ILE   A N   1 
ATOM   1960 C CA  . ILE   A 1 267 ? 25.17219  -12.02958 -17.64408 1.000 33.57827 ? 463 ILE   A CA  1 
ATOM   1961 C C   . ILE   A 1 267 ? 25.60792  -13.45768 -17.95156 1.000 31.09081 ? 463 ILE   A C   1 
ATOM   1962 O O   . ILE   A 1 267 ? 25.30611  -14.38719 -17.19317 1.000 30.13925 ? 463 ILE   A O   1 
ATOM   1963 C CB  . ILE   A 1 267 ? 23.95927  -11.60260 -18.49317 1.000 29.98337 ? 463 ILE   A CB  1 
ATOM   1964 C CG1 . ILE   A 1 267 ? 23.25790  -10.40115 -17.85944 1.000 24.99290 ? 463 ILE   A CG1 1 
ATOM   1965 C CG2 . ILE   A 1 267 ? 22.96057  -12.75169 -18.62990 1.000 30.00214 ? 463 ILE   A CG2 1 
ATOM   1966 C CD1 . ILE   A 1 267 ? 22.36140  -9.67019  -18.86102 1.000 33.14329 ? 463 ILE   A CD1 1 
ATOM   1967 N N   . TYR   A 1 268 ? 26.33074  -13.65917 -19.05612 1.000 29.77081 ? 464 TYR   A N   1 
ATOM   1968 C CA  . TYR   A 1 268 ? 26.74963  -15.00450 -19.41886 1.000 31.28802 ? 464 TYR   A CA  1 
ATOM   1969 C C   . TYR   A 1 268 ? 27.88910  -15.53217 -18.54597 1.000 33.38684 ? 464 TYR   A C   1 
ATOM   1970 O O   . TYR   A 1 268 ? 28.05428  -16.74895 -18.45629 1.000 33.06916 ? 464 TYR   A O   1 
ATOM   1971 C CB  . TYR   A 1 268 ? 27.16054  -15.05678 -20.88784 1.000 29.81160 ? 464 TYR   A CB  1 
ATOM   1972 C CG  . TYR   A 1 268 ? 25.98828  -15.04514 -21.84926 1.000 36.35967 ? 464 TYR   A CG  1 
ATOM   1973 C CD1 . TYR   A 1 268 ? 25.04776  -16.07258 -21.84662 1.000 34.89452 ? 464 TYR   A CD1 1 
ATOM   1974 C CD2 . TYR   A 1 268 ? 25.83617  -14.02036 -22.77743 1.000 34.94104 ? 464 TYR   A CD2 1 
ATOM   1975 C CE1 . TYR   A 1 268 ? 23.97139  -16.06688 -22.73890 1.000 32.90894 ? 464 TYR   A CE1 1 
ATOM   1976 C CE2 . TYR   A 1 268 ? 24.77336  -14.00223 -23.66402 1.000 35.68772 ? 464 TYR   A CE2 1 
ATOM   1977 C CZ  . TYR   A 1 268 ? 23.83850  -15.02493 -23.64674 1.000 34.13428 ? 464 TYR   A CZ  1 
ATOM   1978 O OH  . TYR   A 1 268 ? 22.78593  -14.99518 -24.55474 1.000 27.79754 ? 464 TYR   A OH  1 
ATOM   1979 N N   . ARG   A 1 269 ? 28.65987  -14.65392 -17.90138 1.000 33.99390 ? 465 ARG   A N   1 
ATOM   1980 C CA  . ARG   A 1 269 ? 29.83148  -15.03799 -17.11659 1.000 36.02753 ? 465 ARG   A CA  1 
ATOM   1981 C C   . ARG   A 1 269 ? 29.43134  -15.88711 -15.91485 1.000 42.34279 ? 465 ARG   A C   1 
ATOM   1982 O O   . ARG   A 1 269 ? 28.74391  -15.39223 -15.01469 1.000 38.70208 ? 465 ARG   A O   1 
ATOM   1983 C CB  . ARG   A 1 269 ? 30.57524  -13.78524 -16.64033 1.000 40.57188 ? 465 ARG   A CB  1 
ATOM   1984 C CG  . ARG   A 1 269 ? 31.81352  -14.04176 -15.78404 1.000 49.27946 ? 465 ARG   A CG  1 
ATOM   1985 C CD  . ARG   A 1 269 ? 32.96440  -13.12707 -16.19181 1.000 52.66113 ? 465 ARG   A CD  1 
ATOM   1986 N NE  . ARG   A 1 269 ? 33.25350  -13.17882 -17.62249 1.000 56.88708 ? 465 ARG   A NE  1 
ATOM   1987 C CZ  . ARG   A 1 269 ? 34.41716  -13.55590 -18.13797 1.000 54.14227 ? 465 ARG   A CZ  1 
ATOM   1988 N NH1 . ARG   A 1 269 ? 35.45084  -13.86061 -17.36516 1.000 50.05475 ? 465 ARG   A NH1 1 
ATOM   1989 N NH2 . ARG   A 1 269 ? 34.55019  -13.61964 -19.46091 1.000 48.61304 ? 465 ARG   A NH2 1 
ATOM   1990 N N   . ASP   A 1 270 ? 29.84274  -17.16031 -15.90098 1.000 35.57181 ? 466 ASP   A N   1 
ATOM   1991 C CA  . ASP   A 1 270 ? 29.54738  -18.09157 -14.80346 1.000 44.96235 ? 466 ASP   A CA  1 
ATOM   1992 C C   . ASP   A 1 270 ? 28.06015  -18.42790 -14.70663 1.000 51.01860 ? 466 ASP   A C   1 
ATOM   1993 O O   . ASP   A 1 270 ? 27.52447  -18.57119 -13.60291 1.000 49.10381 ? 466 ASP   A O   1 
ATOM   1994 C CB  . ASP   A 1 270 ? 30.04808  -17.56947 -13.45340 1.000 42.58938 ? 466 ASP   A CB  1 
ATOM   1995 C CG  . ASP   A 1 270 ? 31.55011  -17.56628 -13.35985 1.000 43.56590 ? 466 ASP   A CG  1 
ATOM   1996 O OD1 . ASP   A 1 270 ? 32.14514  -18.61421 -13.69564 1.000 45.16396 ? 466 ASP   A OD1 1 
ATOM   1997 O OD2 . ASP   A 1 270 ? 32.12327  -16.53316 -12.94931 1.000 45.95519 ? 466 ASP   A OD2 1 
ATOM   1998 N N   . MET   A 1 271 ? 27.39319  -18.56475 -15.85335 1.000 41.85320 ? 467 MET   A N   1 
ATOM   1999 C CA  . MET   A 1 271 ? 26.00297  -19.01640 -15.90697 1.000 54.71514 ? 467 MET   A CA  1 
ATOM   2000 C C   . MET   A 1 271 ? 26.01556  -20.32383 -16.69207 1.000 57.17950 ? 467 MET   A C   1 
ATOM   2001 O O   . MET   A 1 271 ? 26.11237  -20.31003 -17.92349 1.000 64.22245 ? 467 MET   A O   1 
ATOM   2002 C CB  . MET   A 1 271 ? 25.08829  -17.98386 -16.57161 1.000 50.84999 ? 467 MET   A CB  1 
ATOM   2003 C CG  . MET   A 1 271 ? 23.68984  -18.52089 -16.92306 1.000 53.64946 ? 467 MET   A CG  1 
ATOM   2004 S SD  . MET   A 1 271 ? 23.03444  -18.03913 -18.53439 1.000 47.56849 ? 467 MET   A SD  1 
ATOM   2005 C CE  . MET   A 1 271 ? 22.81172  -16.28589 -18.29650 1.000 36.64630 ? 467 MET   A CE  1 
ATOM   2006 N N   . TYR   A 1 272 ? 25.91705  -21.44177 -15.98002 1.000 58.19391 ? 468 TYR   A N   1 
ATOM   2007 C CA  . TYR   A 1 272 ? 26.05701  -22.77822 -16.56259 1.000 61.52135 ? 468 TYR   A CA  1 
ATOM   2008 C C   . TYR   A 1 272 ? 27.42318  -22.95340 -17.22556 1.000 63.90130 ? 468 TYR   A C   1 
ATOM   2009 O O   . TYR   A 1 272 ? 28.44994  -23.03557 -16.54903 1.000 61.84011 ? 468 TYR   A O   1 
ATOM   2010 C CB  . TYR   A 1 272 ? 24.94806  -23.07101 -17.58220 1.000 59.92251 ? 468 TYR   A CB  1 
ATOM   2011 C CG  . TYR   A 1 272 ? 23.57283  -22.63273 -17.13874 1.000 54.70010 ? 468 TYR   A CG  1 
ATOM   2012 C CD1 . TYR   A 1 272 ? 23.01571  -23.11856 -15.96258 1.000 54.38141 ? 468 TYR   A CD1 1 
ATOM   2013 C CD2 . TYR   A 1 272 ? 22.80851  -21.76802 -17.92263 1.000 55.45769 ? 468 TYR   A CD2 1 
ATOM   2014 C CE1 . TYR   A 1 272 ? 21.74826  -22.72361 -15.55360 1.000 55.16216 ? 468 TYR   A CE1 1 
ATOM   2015 C CE2 . TYR   A 1 272 ? 21.53469  -21.37139 -17.52653 1.000 47.94647 ? 468 TYR   A CE2 1 
ATOM   2016 C CZ  . TYR   A 1 272 ? 21.01282  -21.85655 -16.33992 1.000 53.82587 ? 468 TYR   A CZ  1 
ATOM   2017 O OH  . TYR   A 1 272 ? 19.75082  -21.47956 -15.92845 1.000 52.94499 ? 468 TYR   A OH  1 
ATOM   2018 O OXT . TYR   A 1 272 ? 27.52989  -23.02195 -18.45298 1.000 73.40081 ? 468 TYR   A OXT 1 
ATOM   2019 N N   . PRO   B 2 7   ? 31.25409  -2.42469  -8.83155  1.000 67.04409 ? 141 PRO   B N   1 
ATOM   2020 C CA  . PRO   B 2 7   ? 30.11063  -3.33221  -8.65665  1.000 66.86553 ? 141 PRO   B CA  1 
ATOM   2021 C C   . PRO   B 2 7   ? 29.84876  -4.16638  -9.91068  1.000 67.47670 ? 141 PRO   B C   1 
ATOM   2022 O O   . PRO   B 2 7   ? 30.72330  -4.92664  -10.34163 1.000 71.17815 ? 141 PRO   B O   1 
ATOM   2023 C CB  . PRO   B 2 7   ? 28.93168  -2.38746  -8.37613  1.000 60.52932 ? 141 PRO   B CB  1 
ATOM   2024 C CG  . PRO   B 2 7   ? 29.54263  -1.07524  -8.00613  1.000 65.34722 ? 141 PRO   B CG  1 
ATOM   2025 C CD  . PRO   B 2 7   ? 30.88437  -1.00800  -8.66686  1.000 69.58874 ? 141 PRO   B CD  1 
ATOM   2026 N N   . SER   B 2 8   ? 28.65741  -4.02322  -10.48803 1.000 52.81905 ? 142 SER   B N   1 
ATOM   2027 C CA  . SER   B 2 8   ? 28.32139  -4.72761  -11.71532 1.000 49.02143 ? 142 SER   B CA  1 
ATOM   2028 C C   . SER   B 2 8   ? 27.25685  -3.93436  -12.45081 1.000 47.35447 ? 142 SER   B C   1 
ATOM   2029 O O   . SER   B 2 8   ? 26.50404  -3.16307  -11.84796 1.000 39.92404 ? 142 SER   B O   1 
ATOM   2030 C CB  . SER   B 2 8   ? 27.83144  -6.15238  -11.44020 1.000 45.74559 ? 142 SER   B CB  1 
ATOM   2031 O OG  . SER   B 2 8   ? 26.48078  -6.14111  -11.01714 1.000 44.28306 ? 142 SER   B OG  1 
ATOM   2032 N N   . LEU   B 2 9   ? 27.21096  -4.13033  -13.77343 1.000 40.51817 ? 143 LEU   B N   1 
ATOM   2033 C CA  . LEU   B 2 9   ? 26.24107  -3.42019  -14.60429 1.000 39.34398 ? 143 LEU   B CA  1 
ATOM   2034 C C   . LEU   B 2 9   ? 24.80735  -3.77813  -14.22592 1.000 43.48886 ? 143 LEU   B C   1 
ATOM   2035 O O   . LEU   B 2 9   ? 23.92452  -2.90900  -14.22182 1.000 40.24087 ? 143 LEU   B O   1 
ATOM   2036 C CB  . LEU   B 2 9   ? 26.51532  -3.72880  -16.07416 1.000 37.21661 ? 143 LEU   B CB  1 
ATOM   2037 C CG  . LEU   B 2 9   ? 27.99426  -3.54950  -16.40080 1.000 43.39778 ? 143 LEU   B CG  1 
ATOM   2038 C CD1 . LEU   B 2 9   ? 28.32802  -3.90000  -17.85020 1.000 45.73365 ? 143 LEU   B CD1 1 
ATOM   2039 C CD2 . LEU   B 2 9   ? 28.35854  -2.11640  -16.12947 1.000 46.13677 ? 143 LEU   B CD2 1 
ATOM   2040 N N   . LEU   B 2 10  ? 24.55178  -5.04980  -13.89843 1.000 38.86966 ? 144 LEU   B N   1 
ATOM   2041 C CA  . LEU   B 2 10  ? 23.22076  -5.42635  -13.43204 1.000 38.40365 ? 144 LEU   B CA  1 
ATOM   2042 C C   . LEU   B 2 10  ? 22.86018  -4.68515  -12.15487 1.000 41.90569 ? 144 LEU   B C   1 
ATOM   2043 O O   . LEU   B 2 10  ? 21.76472  -4.12885  -12.04308 1.000 39.59600 ? 144 LEU   B O   1 
ATOM   2044 C CB  . LEU   B 2 10  ? 23.12574  -6.93437  -13.20166 1.000 35.53163 ? 144 LEU   B CB  1 
ATOM   2045 C CG  . LEU   B 2 10  ? 22.85875  -7.82104  -14.40372 1.000 41.14808 ? 144 LEU   B CG  1 
ATOM   2046 C CD1 . LEU   B 2 10  ? 23.12641  -9.28956  -14.03871 1.000 36.45366 ? 144 LEU   B CD1 1 
ATOM   2047 C CD2 . LEU   B 2 10  ? 21.43577  -7.59773  -14.92293 1.000 40.87091 ? 144 LEU   B CD2 1 
ATOM   2048 N N   . LYS   B 2 11  ? 23.76720  -4.69220  -11.16816 1.000 42.75884 ? 145 LYS   B N   1 
ATOM   2049 C CA  . LYS   B 2 11  ? 23.57303  -3.91303  -9.94621  1.000 40.99254 ? 145 LYS   B CA  1 
ATOM   2050 C C   . LYS   B 2 11  ? 23.19945  -2.47147  -10.25629 1.000 40.85563 ? 145 LYS   B C   1 
ATOM   2051 O O   . LYS   B 2 11  ? 22.27864  -1.91172  -9.65095  1.000 40.77343 ? 145 LYS   B O   1 
ATOM   2052 C CB  . LYS   B 2 11  ? 24.84620  -3.94209  -9.09979  1.000 44.48684 ? 145 LYS   B CB  1 
ATOM   2053 C CG  . LYS   B 2 11  ? 24.98894  -5.11246  -8.16957  1.000 49.08132 ? 145 LYS   B CG  1 
ATOM   2054 C CD  . LYS   B 2 11  ? 24.74079  -4.67561  -6.73351  1.000 53.90539 ? 145 LYS   B CD  1 
ATOM   2055 C CE  . LYS   B 2 11  ? 24.90448  -5.82513  -5.75610  1.000 48.41773 ? 145 LYS   B CE  1 
ATOM   2056 N NZ  . LYS   B 2 11  ? 26.32945  -6.05151  -5.38447  1.000 59.48916 ? 145 LYS   B NZ  1 
ATOM   2057 N N   . LYS   B 2 12  ? 23.93873  -1.84276  -11.17455 1.000 39.69350 ? 146 LYS   B N   1 
ATOM   2058 C CA  . LYS   B 2 12  ? 23.62949  -0.47252  -11.57221 1.000 43.77027 ? 146 LYS   B CA  1 
ATOM   2059 C C   . LYS   B 2 12  ? 22.20578  -0.36198  -12.09978 1.000 45.79328 ? 146 LYS   B C   1 
ATOM   2060 O O   . LYS   B 2 12  ? 21.44834  0.52635   -11.69347 1.000 42.49022 ? 146 LYS   B O   1 
ATOM   2061 C CB  . LYS   B 2 12  ? 24.62657  0.00968   -12.62619 1.000 45.69099 ? 146 LYS   B CB  1 
ATOM   2062 C CG  . LYS   B 2 12  ? 25.97630  0.44907   -12.08370 1.000 51.79571 ? 146 LYS   B CG  1 
ATOM   2063 C CD  . LYS   B 2 12  ? 26.61669  1.48068   -13.02124 1.000 62.89170 ? 146 LYS   B CD  1 
ATOM   2064 C CE  . LYS   B 2 12  ? 27.27568  0.81221   -14.22369 1.000 53.79994 ? 146 LYS   B CE  1 
ATOM   2065 N NZ  . LYS   B 2 12  ? 26.92632  1.45391   -15.53331 1.000 59.55766 ? 146 LYS   B NZ  1 
ATOM   2066 N N   . LEU   B 2 13  ? 21.82291  -1.27034  -13.00354 1.000 41.19963 ? 147 LEU   B N   1 
ATOM   2067 C CA  . LEU   B 2 13  ? 20.46848  -1.26166  -13.55027 1.000 40.20626 ? 147 LEU   B CA  1 
ATOM   2068 C C   . LEU   B 2 13  ? 19.41808  -1.34624  -12.45049 1.000 42.97341 ? 147 LEU   B C   1 
ATOM   2069 O O   . LEU   B 2 13  ? 18.40139  -0.64154  -12.49802 1.000 40.78427 ? 147 LEU   B O   1 
ATOM   2070 C CB  . LEU   B 2 13  ? 20.30734  -2.42298  -14.53080 1.000 44.65056 ? 147 LEU   B CB  1 
ATOM   2071 C CG  . LEU   B 2 13  ? 20.86611  -2.17984  -15.93064 1.000 43.97240 ? 147 LEU   B CG  1 
ATOM   2072 C CD1 . LEU   B 2 13  ? 20.71401  -3.42244  -16.79994 1.000 38.95584 ? 147 LEU   B CD1 1 
ATOM   2073 C CD2 . LEU   B 2 13  ? 20.17100  -0.99898  -16.56746 1.000 44.37235 ? 147 LEU   B CD2 1 
ATOM   2074 N N   . LEU   B 2 14  ? 19.64083  -2.20656  -11.44989 1.000 36.10548 ? 148 LEU   B N   1 
ATOM   2075 C CA  . LEU   B 2 14  ? 18.65280  -2.36052  -10.38838 1.000 42.53226 ? 148 LEU   B CA  1 
ATOM   2076 C C   . LEU   B 2 14  ? 18.55507  -1.12396  -9.50636  1.000 45.24733 ? 148 LEU   B C   1 
ATOM   2077 O O   . LEU   B 2 14  ? 17.56110  -0.96487  -8.79051  1.000 49.18786 ? 148 LEU   B O   1 
ATOM   2078 C CB  . LEU   B 2 14  ? 18.98098  -3.58809  -9.53883  1.000 39.68906 ? 148 LEU   B CB  1 
ATOM   2079 C CG  . LEU   B 2 14  ? 18.44988  -4.89955  -10.12551 1.000 39.62334 ? 148 LEU   B CG  1 
ATOM   2080 C CD1 . LEU   B 2 14  ? 19.19202  -6.11113  -9.58137  1.000 37.20867 ? 148 LEU   B CD1 1 
ATOM   2081 C CD2 . LEU   B 2 14  ? 16.95643  -5.01927  -9.84781  1.000 33.83080 ? 148 LEU   B CD2 1 
ATOM   2082 N N   . LEU   B 2 15  ? 19.55050  -0.24104  -9.55237  1.000 49.15655 ? 149 LEU   B N   1 
ATOM   2083 C CA  . LEU   B 2 15  ? 19.58962  0.92438   -8.67090  1.000 52.44504 ? 149 LEU   B CA  1 
ATOM   2084 C C   . LEU   B 2 15  ? 19.12175  2.16069   -9.43961  1.000 57.06896 ? 149 LEU   B C   1 
ATOM   2085 O O   . LEU   B 2 15  ? 19.90250  3.03749   -9.81018  1.000 66.83494 ? 149 LEU   B O   1 
ATOM   2086 C CB  . LEU   B 2 15  ? 20.99476  1.10145   -8.10626  1.000 48.38112 ? 149 LEU   B CB  1 
ATOM   2087 C CG  . LEU   B 2 15  ? 21.34842  0.09734   -7.00732  1.000 52.41436 ? 149 LEU   B CG  1 
ATOM   2088 C CD1 . LEU   B 2 15  ? 22.63244  0.47426   -6.29326  1.000 47.17101 ? 149 LEU   B CD1 1 
ATOM   2089 C CD2 . LEU   B 2 15  ? 20.19909  -0.03853  -6.01892  1.000 55.79251 ? 149 LEU   B CD2 1 
ATOM   2090 N N   . ALA   B 2 16  ? 17.81050  2.19892   -9.68850  1.000 61.97842 ? 150 ALA   B N   1 
ATOM   2091 C CA  . ALA   B 2 16  ? 17.14417  3.30129   -10.39434 1.000 54.82847 ? 150 ALA   B CA  1 
ATOM   2092 C C   . ALA   B 2 16  ? 17.74732  3.58444   -11.77195 1.000 59.84344 ? 150 ALA   B C   1 
ATOM   2093 O O   . ALA   B 2 16  ? 18.60709  2.84866   -12.26100 1.000 59.39312 ? 150 ALA   B O   1 
ATOM   2094 C CB  . ALA   B 2 16  ? 17.16711  4.57546   -9.53909  1.000 54.54034 ? 150 ALA   B CB  1 
HETATM 2095 C C01 . A1LZ9 C 3 .   ? 19.28191  -12.85483 -30.27135 1.000 25.48480 ? 500 A1LZ9 A C01 1 
HETATM 2096 C C02 . A1LZ9 C 3 .   ? 19.78189  -12.79207 -28.97329 1.000 20.84183 ? 500 A1LZ9 A C02 1 
HETATM 2097 C C03 . A1LZ9 C 3 .   ? 21.13170  -13.09524 -28.73581 1.000 23.93955 ? 500 A1LZ9 A C03 1 
HETATM 2098 C C04 . A1LZ9 C 3 .   ? 21.93330  -13.43668 -29.83832 1.000 25.21341 ? 500 A1LZ9 A C04 1 
HETATM 2099 C C05 . A1LZ9 C 3 .   ? 21.33604  -13.46763 -31.11187 1.000 26.98109 ? 500 A1LZ9 A C05 1 
HETATM 2100 C C06 . A1LZ9 C 3 .   ? 23.30314  -13.80403 -30.09740 1.000 27.03493 ? 500 A1LZ9 A C06 1 
HETATM 2101 C C07 . A1LZ9 C 3 .   ? 17.82339  -12.52824 -30.51788 1.000 23.88009 ? 500 A1LZ9 A C07 1 
HETATM 2102 C C08 . A1LZ9 C 3 .   ? 21.67322  -12.94661 -27.32133 1.000 24.10314 ? 500 A1LZ9 A C08 1 
HETATM 2103 C C09 . A1LZ9 C 3 .   ? 24.44713  -13.93839 -29.09309 1.000 28.60641 ? 500 A1LZ9 A C09 1 
HETATM 2104 C C10 . A1LZ9 C 3 .   ? 25.52780  -14.92526 -29.58351 1.000 28.48001 ? 500 A1LZ9 A C10 1 
HETATM 2105 C C11 . A1LZ9 C 3 .   ? 25.07025  -12.56089 -28.85434 1.000 31.25044 ? 500 A1LZ9 A C11 1 
HETATM 2106 C C12 . A1LZ9 C 3 .   ? 25.04913  -16.34509 -29.93265 1.000 28.12386 ? 500 A1LZ9 A C12 1 
HETATM 2107 C C13 . A1LZ9 C 3 .   ? 25.75557  -12.45391 -27.50181 1.000 35.26185 ? 500 A1LZ9 A C13 1 
HETATM 2108 C C14 . A1LZ9 C 3 .   ? 20.99658  -14.43365 -34.06438 1.000 27.92474 ? 500 A1LZ9 A C14 1 
HETATM 2109 C C15 . A1LZ9 C 3 .   ? 20.97281  -14.48985 -35.44334 1.000 24.89595 ? 500 A1LZ9 A C15 1 
HETATM 2110 C C16 . A1LZ9 C 3 .   ? 22.07058  -14.06995 -36.18767 1.000 28.87260 ? 500 A1LZ9 A C16 1 
HETATM 2111 C C17 . A1LZ9 C 3 .   ? 23.19048  -13.57857 -35.55933 1.000 27.58666 ? 500 A1LZ9 A C17 1 
HETATM 2112 C C18 . A1LZ9 C 3 .   ? 23.20887  -13.51730 -34.17847 1.000 29.94516 ? 500 A1LZ9 A C18 1 
HETATM 2113 C C19 . A1LZ9 C 3 .   ? 22.12373  -13.96132 -33.42608 1.000 26.18412 ? 500 A1LZ9 A C19 1 
HETATM 2114 C C26 . A1LZ9 C 3 .   ? 17.69357  -11.15454 -31.15160 1.000 28.13628 ? 500 A1LZ9 A C26 1 
HETATM 2115 C C28 . A1LZ9 C 3 .   ? 15.97275  -10.07883 -32.28495 1.000 28.34699 ? 500 A1LZ9 A C28 1 
HETATM 2116 C C29 . A1LZ9 C 3 .   ? 16.68189  -9.88941  -33.62279 1.000 22.64814 ? 500 A1LZ9 A C29 1 
HETATM 2117 C C30 . A1LZ9 C 3 .   ? 17.19155  -10.79722 -34.57901 1.000 29.01833 ? 500 A1LZ9 A C30 1 
HETATM 2118 C C32 . A1LZ9 C 3 .   ? 17.53147  -8.82440  -35.30225 1.000 27.39062 ? 500 A1LZ9 A C32 1 
HETATM 2119 C C34 . A1LZ9 C 3 .   ? 17.94000  -7.69519  -36.21408 1.000 31.89252 ? 500 A1LZ9 A C34 1 
HETATM 2120 C C35 . A1LZ9 C 3 .   ? 18.46253  -7.99441  -37.46458 1.000 34.75026 ? 500 A1LZ9 A C35 1 
HETATM 2121 C C36 . A1LZ9 C 3 .   ? 18.81896  -6.95479  -38.30423 1.000 34.30608 ? 500 A1LZ9 A C36 1 
HETATM 2122 C C37 . A1LZ9 C 3 .   ? 18.62790  -5.64493  -37.87675 1.000 33.59227 ? 500 A1LZ9 A C37 1 
HETATM 2123 C C38 . A1LZ9 C 3 .   ? 18.09589  -5.34808  -36.64154 1.000 30.94875 ? 500 A1LZ9 A C38 1 
HETATM 2124 C C39 . A1LZ9 C 3 .   ? 17.74168  -6.38499  -35.79709 1.000 32.59316 ? 500 A1LZ9 A C39 1 
HETATM 2125 C C40 . A1LZ9 C 3 .   ? 17.23583  -12.32230 -34.56212 1.000 26.01529 ? 500 A1LZ9 A C40 1 
HETATM 2126 F F20 . A1LZ9 C 3 .   ? 22.04405  -14.13749 -37.55046 1.000 28.74342 ? 500 A1LZ9 A F20 1 
HETATM 2127 N N21 . A1LZ9 C 3 .   ? 20.04128  -13.18997 -31.29679 1.000 24.63811 ? 500 A1LZ9 A N21 1 
HETATM 2128 N N22 . A1LZ9 C 3 .   ? 23.41941  -14.01855 -31.38205 1.000 25.69979 ? 500 A1LZ9 A N22 1 
HETATM 2129 N N23 . A1LZ9 C 3 .   ? 22.26684  -13.83610 -31.99621 1.000 27.69622 ? 500 A1LZ9 A N23 1 
HETATM 2130 N N33 . A1LZ9 C 3 .   ? 16.91943  -8.66572  -34.14254 1.000 26.80790 ? 500 A1LZ9 A N33 1 
HETATM 2131 O O24 . A1LZ9 C 3 .   ? 21.46192  -11.82398 -26.76312 1.000 24.24999 ? 500 A1LZ9 A O24 1 
HETATM 2132 O O25 . A1LZ9 C 3 .   ? 22.36141  -13.81276 -26.73900 1.000 26.12486 ? 500 A1LZ9 A O25 1 
HETATM 2133 O O27 . A1LZ9 C 3 .   ? 16.42965  -11.25798 -31.73947 1.000 37.84434 ? 500 A1LZ9 A O27 1 
HETATM 2134 O O31 . A1LZ9 C 3 .   ? 17.68916  -10.08899 -35.54625 1.000 28.05347 ? 500 A1LZ9 A O31 1 
HETATM 2135 O O   . HOH   D 4 .   ? 1.81524   -12.09415 -40.99218 1.000 48.44277 ? 601 HOH   A O   1 
HETATM 2136 O O   . HOH   D 4 .   ? 19.64812  -21.69663 -5.23285  1.000 50.75205 ? 602 HOH   A O   1 
HETATM 2137 O O   . HOH   D 4 .   ? 16.96483  -0.43109  -15.30976 1.000 47.17506 ? 603 HOH   A O   1 
HETATM 2138 O O   . HOH   D 4 .   ? 14.90663  -27.43545 -32.27827 1.000 48.63491 ? 604 HOH   A O   1 
HETATM 2139 O O   . HOH   D 4 .   ? 1.67022   -4.31120  -40.82121 1.000 49.18401 ? 605 HOH   A O   1 
HETATM 2140 O O   . HOH   D 4 .   ? -6.97331  -14.73690 -24.71145 1.000 47.91240 ? 606 HOH   A O   1 
HETATM 2141 O O   . HOH   D 4 .   ? 15.49800  -27.79893 -18.25284 1.000 41.41958 ? 607 HOH   A O   1 
HETATM 2142 O O   . HOH   D 4 .   ? 18.39622  -20.02355 -17.54236 1.000 36.60704 ? 608 HOH   A O   1 
HETATM 2143 O O   . HOH   D 4 .   ? 22.30903  -5.94740  -39.57139 1.000 40.53888 ? 609 HOH   A O   1 
HETATM 2144 O O   . HOH   D 4 .   ? 4.50377   -0.43470  -23.28087 1.000 41.19293 ? 610 HOH   A O   1 
HETATM 2145 O O   . HOH   D 4 .   ? 29.34425  -13.38524 -44.76894 1.000 43.49636 ? 611 HOH   A O   1 
HETATM 2146 O O   . HOH   D 4 .   ? 19.29911  -24.99740 -28.68217 1.000 34.06658 ? 612 HOH   A O   1 
HETATM 2147 O O   . HOH   D 4 .   ? 27.54583  1.88171   -43.57959 1.000 44.62211 ? 613 HOH   A O   1 
HETATM 2148 O O   . HOH   D 4 .   ? 13.83058  -25.50898 -29.50863 1.000 33.75841 ? 614 HOH   A O   1 
HETATM 2149 O O   . HOH   D 4 .   ? 13.59393  -15.76575 -47.03086 1.000 36.20965 ? 615 HOH   A O   1 
HETATM 2150 O O   . HOH   D 4 .   ? -13.69761 -18.78388 -17.82274 1.000 45.80096 ? 616 HOH   A O   1 
HETATM 2151 O O   . HOH   D 4 .   ? 11.60987  -8.07725  -32.26693 1.000 38.56605 ? 617 HOH   A O   1 
HETATM 2152 O O   . HOH   D 4 .   ? -0.37565  -17.51943 -30.11801 1.000 31.14502 ? 618 HOH   A O   1 
HETATM 2153 O O   . HOH   D 4 .   ? 19.29532  -19.72387 1.84834   1.000 49.95454 ? 619 HOH   A O   1 
HETATM 2154 O O   . HOH   D 4 .   ? 38.47368  -22.10747 -24.51720 1.000 35.76140 ? 620 HOH   A O   1 
HETATM 2155 O O   . HOH   D 4 .   ? 3.84920   -2.89046  -9.06326  1.000 45.51089 ? 621 HOH   A O   1 
HETATM 2156 O O   . HOH   D 4 .   ? 9.15323   -4.90604  -6.12007  1.000 32.44667 ? 622 HOH   A O   1 
HETATM 2157 O O   . HOH   D 4 .   ? 6.00841   -6.54159  -45.28210 1.000 50.61293 ? 623 HOH   A O   1 
HETATM 2158 O O   . HOH   D 4 .   ? 5.21583   -14.96888 -26.09733 1.000 24.62634 ? 624 HOH   A O   1 
HETATM 2159 O O   . HOH   D 4 .   ? 22.84209  -14.11465 -4.83174  1.000 38.66589 ? 625 HOH   A O   1 
HETATM 2160 O O   . HOH   D 4 .   ? 6.98268   -28.47618 -24.36926 1.000 36.70927 ? 626 HOH   A O   1 
HETATM 2161 O O   . HOH   D 4 .   ? -6.35818  -23.80441 -18.05381 1.000 32.74694 ? 627 HOH   A O   1 
HETATM 2162 O O   . HOH   D 4 .   ? 15.23683  -0.58628  -23.39120 1.000 41.70246 ? 628 HOH   A O   1 
HETATM 2163 O O   . HOH   D 4 .   ? 16.09227  -19.69772 -38.73887 1.000 26.51484 ? 629 HOH   A O   1 
HETATM 2164 O O   . HOH   D 4 .   ? 3.09135   -16.58505 -27.41361 1.000 24.99459 ? 630 HOH   A O   1 
HETATM 2165 O O   . HOH   D 4 .   ? 7.64468   -24.62097 -27.00673 1.000 32.43298 ? 631 HOH   A O   1 
HETATM 2166 O O   . HOH   D 4 .   ? 9.20814   -13.52400 0.38847   1.000 38.35929 ? 632 HOH   A O   1 
HETATM 2167 O O   . HOH   D 4 .   ? 1.90378   -2.63375  -11.43097 1.000 34.31683 ? 633 HOH   A O   1 
HETATM 2168 O O   . HOH   D 4 .   ? -6.86367  -13.43399 -13.23961 1.000 40.67043 ? 634 HOH   A O   1 
HETATM 2169 O O   . HOH   D 4 .   ? 15.28299  -15.97644 -12.11070 1.000 28.84607 ? 635 HOH   A O   1 
HETATM 2170 O O   . HOH   D 4 .   ? -11.60353 -23.66735 -26.94608 1.000 49.83434 ? 636 HOH   A O   1 
HETATM 2171 O O   . HOH   D 4 .   ? 5.38396   -10.96467 -25.13015 1.000 27.16501 ? 637 HOH   A O   1 
HETATM 2172 O O   . HOH   D 4 .   ? -8.98799  -29.45912 -21.80150 1.000 40.34901 ? 638 HOH   A O   1 
HETATM 2173 O O   . HOH   D 4 .   ? -5.483    -30.069   -22.560   1.000 47.17258 ? 639 HOH   A O   1 
HETATM 2174 O O   . HOH   D 4 .   ? 14.44024  -9.09793  -26.99268 1.000 28.21590 ? 640 HOH   A O   1 
HETATM 2175 O O   . HOH   D 4 .   ? 16.82561  -11.91999 -0.51115  1.000 50.69752 ? 641 HOH   A O   1 
HETATM 2176 O O   . HOH   D 4 .   ? 11.15753  -17.81873 -44.11775 1.000 28.31955 ? 642 HOH   A O   1 
HETATM 2177 O O   . HOH   D 4 .   ? 18.66219  -19.76944 -37.72528 1.000 29.21912 ? 643 HOH   A O   1 
HETATM 2178 O O   . HOH   D 4 .   ? 9.00096   -24.90253 -36.58789 1.000 43.58988 ? 644 HOH   A O   1 
HETATM 2179 O O   . HOH   D 4 .   ? 18.92178  -21.68527 -13.30880 1.000 40.20624 ? 645 HOH   A O   1 
HETATM 2180 O O   . HOH   D 4 .   ? 11.81219  -6.41127  -48.88387 1.000 39.45723 ? 646 HOH   A O   1 
HETATM 2181 O O   . HOH   D 4 .   ? -4.40733  -23.34212 -24.90285 1.000 32.66307 ? 647 HOH   A O   1 
HETATM 2182 O O   . HOH   D 4 .   ? 9.43516   -0.53705  -12.06744 1.000 38.65525 ? 648 HOH   A O   1 
HETATM 2183 O O   . HOH   D 4 .   ? 2.39339   -21.95041 -33.88236 1.000 39.93303 ? 649 HOH   A O   1 
HETATM 2184 O O   . HOH   D 4 .   ? 10.76468  -0.57906  -19.13582 1.000 36.92211 ? 650 HOH   A O   1 
HETATM 2185 O O   . HOH   D 4 .   ? 21.83070  -24.80232 -32.78380 1.000 43.81394 ? 651 HOH   A O   1 
HETATM 2186 O O   . HOH   D 4 .   ? 4.52166   -27.88378 -22.76418 1.000 33.91825 ? 652 HOH   A O   1 
HETATM 2187 O O   . HOH   D 4 .   ? 1.14464   -18.61601 -26.68061 1.000 23.65184 ? 653 HOH   A O   1 
HETATM 2188 O O   . HOH   D 4 .   ? 20.13196  -17.70917 -36.63165 1.000 26.02042 ? 654 HOH   A O   1 
HETATM 2189 O O   . HOH   D 4 .   ? 3.06636   -19.20795 -37.89610 1.000 44.79092 ? 655 HOH   A O   1 
HETATM 2190 O O   . HOH   D 4 .   ? 18.488    4.416     -38.898   1.000 36.90295 ? 656 HOH   A O   1 
HETATM 2191 O O   . HOH   D 4 .   ? -9.78124  -19.51630 -11.53882 1.000 41.41252 ? 657 HOH   A O   1 
HETATM 2192 O O   . HOH   D 4 .   ? -4.30512  -9.76265  -22.36758 1.000 35.35524 ? 658 HOH   A O   1 
HETATM 2193 O O   . HOH   D 4 .   ? -2.19778  -6.59338  -24.16748 1.000 39.87806 ? 659 HOH   A O   1 
HETATM 2194 O O   . HOH   D 4 .   ? 22.18915  4.66808   -36.45570 1.000 51.63265 ? 660 HOH   A O   1 
HETATM 2195 O O   . HOH   D 4 .   ? -3.94602  -26.59208 -15.74947 1.000 31.84767 ? 661 HOH   A O   1 
HETATM 2196 O O   . HOH   D 4 .   ? 8.20187   1.88182   -15.67864 1.000 48.00319 ? 662 HOH   A O   1 
HETATM 2197 O O   . HOH   D 4 .   ? 34.36830  -12.68513 -36.78558 1.000 46.67994 ? 663 HOH   A O   1 
HETATM 2198 O O   . HOH   D 4 .   ? 40.38644  -24.11725 -27.24631 1.000 46.43226 ? 664 HOH   A O   1 
HETATM 2199 O O   . HOH   D 4 .   ? 1.73801   -13.93102 -38.34083 1.000 46.39409 ? 665 HOH   A O   1 
HETATM 2200 O O   . HOH   D 4 .   ? 10.48074  -4.53604  -30.10608 1.000 33.72397 ? 666 HOH   A O   1 
HETATM 2201 O O   . HOH   D 4 .   ? 6.45853   -0.07097  -34.61167 1.000 41.18912 ? 667 HOH   A O   1 
HETATM 2202 O O   . HOH   D 4 .   ? 30.85445  -23.53123 -25.93652 1.000 46.12946 ? 668 HOH   A O   1 
HETATM 2203 O O   . HOH   D 4 .   ? 10.23020  -5.69710  -32.95945 1.000 32.11599 ? 669 HOH   A O   1 
HETATM 2204 O O   . HOH   D 4 .   ? 15.23297  -2.95076  -3.66495  1.000 47.01027 ? 670 HOH   A O   1 
HETATM 2205 O O   . HOH   D 4 .   ? 17.86258  -21.01775 -46.02631 1.000 40.63160 ? 671 HOH   A O   1 
HETATM 2206 O O   . HOH   D 4 .   ? 19.13798  -22.46890 -27.96743 1.000 27.00106 ? 672 HOH   A O   1 
HETATM 2207 O O   . HOH   D 4 .   ? 9.52922   -26.54896 -14.56773 1.000 38.01677 ? 673 HOH   A O   1 
HETATM 2208 O O   . HOH   D 4 .   ? 24.35297  -25.31179 -28.41736 1.000 43.44955 ? 674 HOH   A O   1 
HETATM 2209 O O   . HOH   D 4 .   ? 9.55888   -5.05406  -47.55789 1.000 42.50803 ? 675 HOH   A O   1 
HETATM 2210 O O   . HOH   D 4 .   ? 13.28445  -4.20047  -31.14964 1.000 31.98908 ? 676 HOH   A O   1 
HETATM 2211 O O   . HOH   D 4 .   ? 14.57592  -26.73862 -24.97289 1.000 30.58078 ? 677 HOH   A O   1 
HETATM 2212 O O   . HOH   D 4 .   ? 3.83516   -4.50261  -23.04537 1.000 31.22186 ? 678 HOH   A O   1 
HETATM 2213 O O   . HOH   D 4 .   ? 12.24368  -18.02759 -28.71009 1.000 31.05891 ? 679 HOH   A O   1 
HETATM 2214 O O   . HOH   D 4 .   ? 16.84492  -9.98713  -28.08559 1.000 26.86139 ? 680 HOH   A O   1 
HETATM 2215 O O   . HOH   D 4 .   ? 29.42320  -11.84165 -14.02343 1.000 46.32057 ? 681 HOH   A O   1 
HETATM 2216 O O   . HOH   D 4 .   ? 13.16261  -26.80081 -37.49204 1.000 47.78241 ? 682 HOH   A O   1 
HETATM 2217 O O   . HOH   D 4 .   ? 8.57729   -26.95123 -33.03020 1.000 47.29396 ? 683 HOH   A O   1 
HETATM 2218 O O   . HOH   D 4 .   ? 10.60483  0.67293   -23.11461 1.000 44.61076 ? 684 HOH   A O   1 
HETATM 2219 O O   . HOH   D 4 .   ? 24.64397  -11.80584 -7.07316  1.000 43.18568 ? 685 HOH   A O   1 
HETATM 2220 O O   . HOH   D 4 .   ? 1.60121   -22.13759 -5.79896  1.000 43.07878 ? 686 HOH   A O   1 
HETATM 2221 O O   . HOH   D 4 .   ? 14.49743  -14.75292 -50.87047 1.000 50.06791 ? 687 HOH   A O   1 
HETATM 2222 O O   . HOH   D 4 .   ? 19.49989  -15.45908 -18.43492 1.000 25.75953 ? 688 HOH   A O   1 
HETATM 2223 O O   . HOH   D 4 .   ? 12.31353  -10.63597 -25.88865 1.000 30.13533 ? 689 HOH   A O   1 
HETATM 2224 O O   . HOH   D 4 .   ? 11.43435  -21.40149 -11.48492 1.000 46.95626 ? 690 HOH   A O   1 
HETATM 2225 O O   . HOH   D 4 .   ? 31.39622  -7.24269  -18.06126 1.000 36.85725 ? 691 HOH   A O   1 
HETATM 2226 O O   . HOH   D 4 .   ? 15.22142  -6.49864  -33.17749 1.000 28.87471 ? 692 HOH   A O   1 
HETATM 2227 O O   . HOH   D 4 .   ? -3.14082  -14.19988 -28.05402 1.000 38.60493 ? 693 HOH   A O   1 
HETATM 2228 O O   . HOH   D 4 .   ? 9.91461   -26.47600 -26.20974 1.000 38.29611 ? 694 HOH   A O   1 
HETATM 2229 O O   . HOH   D 4 .   ? 20.82309  -10.17166 -52.42859 1.000 40.78077 ? 695 HOH   A O   1 
HETATM 2230 O O   . HOH   D 4 .   ? 13.43602  -22.14763 -15.27814 1.000 39.28424 ? 696 HOH   A O   1 
HETATM 2231 O O   . HOH   D 4 .   ? -7.852    -12.159   -21.756   1.000 42.45437 ? 697 HOH   A O   1 
HETATM 2232 O O   . HOH   D 4 .   ? -13.15059 -21.11713 -15.58595 1.000 48.59346 ? 698 HOH   A O   1 
HETATM 2233 O O   . HOH   D 4 .   ? -2.65269  -10.42555 -25.90576 1.000 34.61002 ? 699 HOH   A O   1 
HETATM 2234 O O   . HOH   D 4 .   ? 4.64761   -10.77269 -3.04859  1.000 47.51046 ? 700 HOH   A O   1 
HETATM 2235 O O   . HOH   D 4 .   ? 15.43139  -2.75902  -6.43485  1.000 45.47059 ? 701 HOH   A O   1 
HETATM 2236 O O   . HOH   D 4 .   ? 26.29499  -27.00384 -19.79436 1.000 52.73945 ? 702 HOH   A O   1 
HETATM 2237 O O   . HOH   D 4 .   ? 28.80821  -22.34258 -43.17882 1.000 43.88465 ? 703 HOH   A O   1 
HETATM 2238 O O   . HOH   D 4 .   ? 8.17507   -22.23529 -4.40931  1.000 44.09996 ? 704 HOH   A O   1 
HETATM 2239 O O   . HOH   D 4 .   ? 9.56296   -5.53499  -25.56104 1.000 35.18202 ? 705 HOH   A O   1 
HETATM 2240 O O   . HOH   D 4 .   ? -4.62122  -23.99547 -13.77906 1.000 38.19894 ? 706 HOH   A O   1 
HETATM 2241 O O   . HOH   D 4 .   ? -4.20877  -11.90534 -8.12579  1.000 42.29477 ? 707 HOH   A O   1 
HETATM 2242 O O   . HOH   D 4 .   ? 29.12003  -10.14008 -45.77860 1.000 40.40603 ? 708 HOH   A O   1 
HETATM 2243 O O   . HOH   D 4 .   ? 7.13625   0.01140   -13.64409 1.000 38.68049 ? 709 HOH   A O   1 
HETATM 2244 O O   . HOH   D 4 .   ? 16.31538  -19.90431 3.20489   1.000 41.38445 ? 710 HOH   A O   1 
HETATM 2245 O O   . HOH   D 4 .   ? 19.80247  -5.38582  -0.01644  1.000 46.83931 ? 711 HOH   A O   1 
HETATM 2246 O O   . HOH   D 4 .   ? 32.75231  -8.20260  -23.04318 1.000 45.16916 ? 712 HOH   A O   1 
HETATM 2247 O O   . HOH   D 4 .   ? 17.433    -13.187   -53.696   1.000 47.00840 ? 713 HOH   A O   1 
HETATM 2248 O O   . HOH   D 4 .   ? -7.333    -11.823   -19.019   1.000 42.15341 ? 714 HOH   A O   1 
HETATM 2249 O O   . HOH   D 4 .   ? 16.36735  -27.02924 -26.41446 1.000 42.52112 ? 715 HOH   A O   1 
HETATM 2250 O O   . HOH   D 4 .   ? 3.83005   -13.45475 -4.27332  1.000 40.80024 ? 716 HOH   A O   1 
HETATM 2251 O O   . HOH   D 4 .   ? 3.27343   -27.23614 -27.06166 1.000 42.83251 ? 717 HOH   A O   1 
HETATM 2252 O O   . HOH   D 4 .   ? 7.19435   -4.49918  -3.47616  1.000 42.14189 ? 718 HOH   A O   1 
HETATM 2253 O O   . HOH   D 4 .   ? 30.60273  -17.50320 -22.13873 1.000 49.18063 ? 719 HOH   A O   1 
HETATM 2254 O O   . HOH   D 4 .   ? 13.08625  -10.47147 1.76200   1.000 47.04281 ? 720 HOH   A O   1 
HETATM 2255 O O   . HOH   D 4 .   ? 13.64600  -0.29912  -25.53995 1.000 47.29956 ? 721 HOH   A O   1 
HETATM 2256 O O   . HOH   D 4 .   ? 15.95482  -4.81939  0.22936   1.000 54.17870 ? 722 HOH   A O   1 
HETATM 2257 O O   . HOH   D 4 .   ? 21.39591  -3.03185  -50.90670 1.000 38.26010 ? 723 HOH   A O   1 
HETATM 2258 O O   . HOH   D 4 .   ? 29.67219  -13.70228 -12.56437 1.000 51.99239 ? 724 HOH   A O   1 
HETATM 2259 O O   . HOH   D 4 .   ? 3.28891   -18.96765 -34.52220 1.000 31.75615 ? 725 HOH   A O   1 
HETATM 2260 O O   . HOH   D 4 .   ? 23.83562  -22.10042 -44.60263 1.000 48.47194 ? 726 HOH   A O   1 
HETATM 2261 O O   . HOH   D 4 .   ? -8.01733  -26.31462 -25.96272 1.000 45.77827 ? 727 HOH   A O   1 
HETATM 2262 O O   . HOH   D 4 .   ? 14.47500  -4.62721  -27.60534 1.000 39.98093 ? 728 HOH   A O   1 
HETATM 2263 O O   . HOH   D 4 .   ? -2.73980  -11.19091 -15.51649 1.000 34.10852 ? 729 HOH   A O   1 
HETATM 2264 O O   . HOH   D 4 .   ? 4.34895   -12.53683 -41.94095 1.000 47.97768 ? 730 HOH   A O   1 
HETATM 2265 O O   . HOH   D 4 .   ? 32.20072  -10.20996 -17.13079 1.000 44.55850 ? 731 HOH   A O   1 
HETATM 2266 O O   . HOH   D 4 .   ? 13.75142  -29.32799 -23.73607 1.000 44.41757 ? 732 HOH   A O   1 
HETATM 2267 O O   . HOH   D 4 .   ? -4.68384  -24.57058 -16.25737 1.000 31.91559 ? 733 HOH   A O   1 
HETATM 2268 O O   . HOH   D 4 .   ? 6.84097   -24.00613 -38.77496 1.000 44.49913 ? 734 HOH   A O   1 
HETATM 2269 O O   . HOH   D 4 .   ? 28.60591  -18.92766 -21.60175 1.000 49.91627 ? 735 HOH   A O   1 
HETATM 2270 O O   . HOH   D 4 .   ? 26.39542  -18.33699 -46.85655 1.000 51.06353 ? 736 HOH   A O   1 
HETATM 2271 O O   . HOH   D 4 .   ? -2.11006  -15.50069 -31.82091 1.000 54.51995 ? 737 HOH   A O   1 
HETATM 2272 O O   . HOH   D 4 .   ? 12.24616  -25.11823 -14.69599 1.000 43.62147 ? 738 HOH   A O   1 
HETATM 2273 O O   . HOH   D 4 .   ? 9.00601   -7.85629  -24.90404 1.000 42.10023 ? 739 HOH   A O   1 
HETATM 2274 O O   . HOH   D 4 .   ? -4.30366  -11.46724 -5.21099  1.000 50.05484 ? 740 HOH   A O   1 
HETATM 2275 O O   . HOH   D 4 .   ? -0.21611  -20.58214 -33.50746 1.000 46.11871 ? 741 HOH   A O   1 
HETATM 2276 O O   . HOH   D 4 .   ? 10.015    -31.954   -19.154   1.000 42.83827 ? 742 HOH   A O   1 
HETATM 2277 O O   . HOH   D 4 .   ? 3.12833   -0.89715  -12.99062 1.000 40.03077 ? 743 HOH   A O   1 
HETATM 2278 O O   . HOH   D 4 .   ? 13.32994  -7.52815  -28.84898 1.000 39.62421 ? 744 HOH   A O   1 
HETATM 2279 O O   . HOH   D 4 .   ? -6.63163  -9.29341  -4.08420  1.000 54.69716 ? 745 HOH   A O   1 
HETATM 2280 O O   . HOH   D 4 .   ? 10.31789  -9.35497  -27.20587 1.000 44.21336 ? 746 HOH   A O   1 
HETATM 2281 O O   . HOH   D 4 .   ? -4.90322  -9.82754  -15.09580 1.000 43.03106 ? 747 HOH   A O   1 
HETATM 2282 O O   . HOH   D 4 .   ? 14.42301  -27.56068 -15.16288 1.000 47.30388 ? 748 HOH   A O   1 
HETATM 2283 O O   . HOH   D 4 .   ? 2.56906   -28.30449 -24.70493 1.000 46.23989 ? 749 HOH   A O   1 
HETATM 2284 O O   . HOH   D 4 .   ? -2.51794  -11.56700 -28.49148 1.000 44.15925 ? 750 HOH   A O   1 
HETATM 2285 O O   . HOH   D 4 .   ? 38.141    -12.518   -26.705   1.000 52.37982 ? 751 HOH   A O   1 
HETATM 2286 O O   . HOH   D 4 .   ? 22.65064  -1.19980  -20.07602 1.000 47.60944 ? 752 HOH   A O   1 
HETATM 2287 O O   . HOH   D 4 .   ? -7.141    -9.869    -17.662   1.000 48.27965 ? 753 HOH   A O   1 
HETATM 2288 O O   . HOH   D 4 .   ? -14.513   -23.120   -23.286   1.000 44.04325 ? 754 HOH   A O   1 
HETATM 2289 O O   . HOH   D 4 .   ? -11.36589 -30.62768 -21.27095 1.000 48.88271 ? 755 HOH   A O   1 
HETATM 2290 O O   . HOH   D 4 .   ? 18.11649  -3.67426  -0.28925  1.000 56.96375 ? 756 HOH   A O   1 
HETATM 2291 O O   . HOH   D 4 .   ? 13.54219  -7.06265  -31.35662 1.000 39.00708 ? 757 HOH   A O   1 
HETATM 2292 O O   . HOH   D 4 .   ? 26.34560  -25.51689 -13.76247 1.000 53.11026 ? 758 HOH   A O   1 
HETATM 2293 O O   . HOH   D 4 .   ? -2.61476  -4.04553  -24.95177 1.000 42.21573 ? 759 HOH   A O   1 
HETATM 2294 O O   . HOH   D 4 .   ? 21.77912  -25.17713 -30.07026 1.000 46.02081 ? 760 HOH   A O   1 
HETATM 2295 O O   . HOH   D 4 .   ? 33.27496  -6.85424  -20.47719 1.000 48.78121 ? 761 HOH   A O   1 
HETATM 2296 O O   . HOH   D 4 .   ? 31.55481  -10.15809 -14.75429 1.000 43.62135 ? 762 HOH   A O   1 
HETATM 2297 O O   . HOH   D 4 .   ? 27.87486  -20.58083 -46.19063 1.000 52.05891 ? 763 HOH   A O   1 
HETATM 2298 O O   . HOH   D 4 .   ? 10.71765  -17.51627 -46.51315 1.000 41.68946 ? 764 HOH   A O   1 
HETATM 2299 O O   . HOH   D 4 .   ? -3.87127  -10.91637 -30.60822 1.000 46.13736 ? 765 HOH   A O   1 
HETATM 2300 O O   . HOH   D 4 .   ? 12.56080  -26.03965 -26.98351 1.000 39.23369 ? 766 HOH   A O   1 
HETATM 2301 O O   . HOH   D 4 .   ? 5.47008   -0.15186  -9.55488  1.000 47.12689 ? 767 HOH   A O   1 
HETATM 2302 O O   . HOH   D 4 .   ? 14.78455  -30.08530 -16.72724 1.000 52.24235 ? 768 HOH   A O   1 
HETATM 2303 O O   . HOH   D 4 .   ? 22.33517  1.19760   -19.09671 1.000 50.12804 ? 769 HOH   A O   1 
HETATM 2304 O O   . HOH   D 4 .   ? 11.51557  -19.50389 -48.40363 1.000 47.19283 ? 770 HOH   A O   1 
HETATM 2305 O O   . HOH   D 4 .   ? 3.16075   -22.60924 -36.64404 1.000 48.08034 ? 771 HOH   A O   1 
HETATM 2306 O O   . HOH   D 4 .   ? 4.85971   -10.33344 -42.71485 1.000 54.15328 ? 772 HOH   A O   1 
HETATM 2307 O O   . HOH   D 4 .   ? 4.77254   0.29679   -12.11575 1.000 45.24676 ? 773 HOH   A O   1 
HETATM 2308 O O   . HOH   D 4 .   ? 23.78292  -24.77175 -12.73181 1.000 54.22255 ? 774 HOH   A O   1 
HETATM 2309 O O   . HOH   D 4 .   ? 10.37063  -8.25725  -29.54749 1.000 41.96153 ? 775 HOH   A O   1 
HETATM 2310 O O   . HOH   D 4 .   ? 4.81030   -24.14135 -37.27879 1.000 49.13938 ? 776 HOH   A O   1 
HETATM 2311 O O   . HOH   D 4 .   ? 9.428     -10.031   -54.031   1.000 59.62886 ? 777 HOH   A O   1 
HETATM 2312 O O   . HOH   D 4 .   ? 34.19732  -3.76594  -20.47258 1.000 51.35835 ? 778 HOH   A O   1 
HETATM 2313 O O   . HOH   D 4 .   ? -3.10845  -0.89077  -3.64826  1.000 59.16959 ? 779 HOH   A O   1 
HETATM 2314 O O   . HOH   D 4 .   ? -5.33700  -0.29821  -4.97672  1.000 54.32940 ? 780 HOH   A O   1 
HETATM 2315 O O   . HOH   D 4 .   ? 33.18274  -1.73787  -19.75563 1.000 54.52137 ? 781 HOH   A O   1 
HETATM 2316 O O   . HOH   E 4 .   ? 24.88052  -0.98800  -16.30347 1.000 47.04065 ? 201 HOH   B O   1 
HETATM 2317 O O   . HOH   E 4 .   ? 23.24860  1.04204   -15.88316 1.000 51.14527 ? 202 HOH   B O   1 
HETATM 2318 O O   . HOH   E 4 .   ? 24.63314  -1.55974  -18.61201 1.000 46.25823 ? 203 HOH   B O   1 
# 
