data_8YUG
# 
_entry.id   8YUG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YUG         pdb_00008yug 10.2210/pdb8yug/pdb 
WWPDB D_1300046374 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YUG 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              aquarius@mail.ecc.u-tokyo.ac.jp 
_pdbx_contact_author.name_first         Kiyohiko 
_pdbx_contact_author.name_last          Igarashi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5152-7177 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ebi, S.'       1 ? 
'Sunagawa, N.'  2 ? 
'Yamaguchi, S.' 3 ? 
'Igarashi, K.'  4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'X-ray Crystal structure of  glycoside hydrolase family 18 chitinase from Serratia marcescens hexahistigine-tagged SmChiB apo enzyme' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Ebi, S.'      1 ? 
primary 'Igarashi, K.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Chitinase B'   56912.523 1   3.2.1.14 ? ? ? 
2 non-polymer syn GLYCEROL        92.094    35  ?        ? ? ? 
3 non-polymer syn 'ACETATE ION'   59.044    16  ?        ? ? ? 
4 non-polymer syn 'PHOSPHATE ION' 94.971    4   ?        ? ? ? 
5 water       nat water           18.015    785 ?        ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MDSTRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFLDINSNLECAWDPATNDAKARDVVNRLT
ALKAHNPSLRIMFSIGGWYYSNDLGVSHANYVNAVKTPAARTKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVDGFIAALQ
EIRTLLNQQTIADGRQALPYQLTIAGAGGAFFLSRYYSKLAQIVAPLDYINLMTYDLAGPWEKITNHQAALFGDAAGPTF
YNALREANLGWSWEELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYGRAFKGVSGGNGGQYSSHSTPGEDPYP
NADYWLVGCDECVRDKDPRIASYRQLEQMLQGNYGYQRLWNDKTKTPYLYHAQNGLFVTYDDAESFKYKAKYIKQQQLGG
VMFWHLGQDNRNGDLLAALDRYFNAADYDDSQLDMGTGLRYTGVGPGNLPIMTAPAYVPGTTYAQGALVSYQGYVWQTKW
GYITSAPGSDSAWLKVGRLAAAALEHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MDSTRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFLDINSNLECAWDPATNDAKARDVVNRLT
ALKAHNPSLRIMFSIGGWYYSNDLGVSHANYVNAVKTPAARTKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVDGFIAALQ
EIRTLLNQQTIADGRQALPYQLTIAGAGGAFFLSRYYSKLAQIVAPLDYINLMTYDLAGPWEKITNHQAALFGDAAGPTF
YNALREANLGWSWEELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYGRAFKGVSGGNGGQYSSHSTPGEDPYP
NADYWLVGCDECVRDKDPRIASYRQLEQMLQGNYGYQRLWNDKTKTPYLYHAQNGLFVTYDDAESFKYKAKYIKQQQLGG
VMFWHLGQDNRNGDLLAALDRYFNAADYDDSQLDMGTGLRYTGVGPGNLPIMTAPAYVPGTTYAQGALVSYQGYVWQTKW
GYITSAPGSDSAWLKVGRLAAAALEHHHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 GLYCEROL        GOL 
3 'ACETATE ION'   ACT 
4 'PHOSPHATE ION' PO4 
5 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   SER n 
1 4   THR n 
1 5   ARG n 
1 6   LYS n 
1 7   ALA n 
1 8   VAL n 
1 9   ILE n 
1 10  GLY n 
1 11  TYR n 
1 12  TYR n 
1 13  PHE n 
1 14  ILE n 
1 15  PRO n 
1 16  THR n 
1 17  ASN n 
1 18  GLN n 
1 19  ILE n 
1 20  ASN n 
1 21  ASN n 
1 22  TYR n 
1 23  THR n 
1 24  GLU n 
1 25  THR n 
1 26  ASP n 
1 27  THR n 
1 28  SER n 
1 29  VAL n 
1 30  VAL n 
1 31  PRO n 
1 32  PHE n 
1 33  PRO n 
1 34  VAL n 
1 35  SER n 
1 36  ASN n 
1 37  ILE n 
1 38  THR n 
1 39  PRO n 
1 40  ALA n 
1 41  LYS n 
1 42  ALA n 
1 43  LYS n 
1 44  GLN n 
1 45  LEU n 
1 46  THR n 
1 47  HIS n 
1 48  ILE n 
1 49  ASN n 
1 50  PHE n 
1 51  SER n 
1 52  PHE n 
1 53  LEU n 
1 54  ASP n 
1 55  ILE n 
1 56  ASN n 
1 57  SER n 
1 58  ASN n 
1 59  LEU n 
1 60  GLU n 
1 61  CYS n 
1 62  ALA n 
1 63  TRP n 
1 64  ASP n 
1 65  PRO n 
1 66  ALA n 
1 67  THR n 
1 68  ASN n 
1 69  ASP n 
1 70  ALA n 
1 71  LYS n 
1 72  ALA n 
1 73  ARG n 
1 74  ASP n 
1 75  VAL n 
1 76  VAL n 
1 77  ASN n 
1 78  ARG n 
1 79  LEU n 
1 80  THR n 
1 81  ALA n 
1 82  LEU n 
1 83  LYS n 
1 84  ALA n 
1 85  HIS n 
1 86  ASN n 
1 87  PRO n 
1 88  SER n 
1 89  LEU n 
1 90  ARG n 
1 91  ILE n 
1 92  MET n 
1 93  PHE n 
1 94  SER n 
1 95  ILE n 
1 96  GLY n 
1 97  GLY n 
1 98  TRP n 
1 99  TYR n 
1 100 TYR n 
1 101 SER n 
1 102 ASN n 
1 103 ASP n 
1 104 LEU n 
1 105 GLY n 
1 106 VAL n 
1 107 SER n 
1 108 HIS n 
1 109 ALA n 
1 110 ASN n 
1 111 TYR n 
1 112 VAL n 
1 113 ASN n 
1 114 ALA n 
1 115 VAL n 
1 116 LYS n 
1 117 THR n 
1 118 PRO n 
1 119 ALA n 
1 120 ALA n 
1 121 ARG n 
1 122 THR n 
1 123 LYS n 
1 124 PHE n 
1 125 ALA n 
1 126 GLN n 
1 127 SER n 
1 128 CYS n 
1 129 VAL n 
1 130 ARG n 
1 131 ILE n 
1 132 MET n 
1 133 LYS n 
1 134 ASP n 
1 135 TYR n 
1 136 GLY n 
1 137 PHE n 
1 138 ASP n 
1 139 GLY n 
1 140 VAL n 
1 141 ASP n 
1 142 ILE n 
1 143 ASP n 
1 144 TRP n 
1 145 GLU n 
1 146 TYR n 
1 147 PRO n 
1 148 GLN n 
1 149 ALA n 
1 150 ALA n 
1 151 GLU n 
1 152 VAL n 
1 153 ASP n 
1 154 GLY n 
1 155 PHE n 
1 156 ILE n 
1 157 ALA n 
1 158 ALA n 
1 159 LEU n 
1 160 GLN n 
1 161 GLU n 
1 162 ILE n 
1 163 ARG n 
1 164 THR n 
1 165 LEU n 
1 166 LEU n 
1 167 ASN n 
1 168 GLN n 
1 169 GLN n 
1 170 THR n 
1 171 ILE n 
1 172 ALA n 
1 173 ASP n 
1 174 GLY n 
1 175 ARG n 
1 176 GLN n 
1 177 ALA n 
1 178 LEU n 
1 179 PRO n 
1 180 TYR n 
1 181 GLN n 
1 182 LEU n 
1 183 THR n 
1 184 ILE n 
1 185 ALA n 
1 186 GLY n 
1 187 ALA n 
1 188 GLY n 
1 189 GLY n 
1 190 ALA n 
1 191 PHE n 
1 192 PHE n 
1 193 LEU n 
1 194 SER n 
1 195 ARG n 
1 196 TYR n 
1 197 TYR n 
1 198 SER n 
1 199 LYS n 
1 200 LEU n 
1 201 ALA n 
1 202 GLN n 
1 203 ILE n 
1 204 VAL n 
1 205 ALA n 
1 206 PRO n 
1 207 LEU n 
1 208 ASP n 
1 209 TYR n 
1 210 ILE n 
1 211 ASN n 
1 212 LEU n 
1 213 MET n 
1 214 THR n 
1 215 TYR n 
1 216 ASP n 
1 217 LEU n 
1 218 ALA n 
1 219 GLY n 
1 220 PRO n 
1 221 TRP n 
1 222 GLU n 
1 223 LYS n 
1 224 ILE n 
1 225 THR n 
1 226 ASN n 
1 227 HIS n 
1 228 GLN n 
1 229 ALA n 
1 230 ALA n 
1 231 LEU n 
1 232 PHE n 
1 233 GLY n 
1 234 ASP n 
1 235 ALA n 
1 236 ALA n 
1 237 GLY n 
1 238 PRO n 
1 239 THR n 
1 240 PHE n 
1 241 TYR n 
1 242 ASN n 
1 243 ALA n 
1 244 LEU n 
1 245 ARG n 
1 246 GLU n 
1 247 ALA n 
1 248 ASN n 
1 249 LEU n 
1 250 GLY n 
1 251 TRP n 
1 252 SER n 
1 253 TRP n 
1 254 GLU n 
1 255 GLU n 
1 256 LEU n 
1 257 THR n 
1 258 ARG n 
1 259 ALA n 
1 260 PHE n 
1 261 PRO n 
1 262 SER n 
1 263 PRO n 
1 264 PHE n 
1 265 SER n 
1 266 LEU n 
1 267 THR n 
1 268 VAL n 
1 269 ASP n 
1 270 ALA n 
1 271 ALA n 
1 272 VAL n 
1 273 GLN n 
1 274 GLN n 
1 275 HIS n 
1 276 LEU n 
1 277 MET n 
1 278 MET n 
1 279 GLU n 
1 280 GLY n 
1 281 VAL n 
1 282 PRO n 
1 283 SER n 
1 284 ALA n 
1 285 LYS n 
1 286 ILE n 
1 287 VAL n 
1 288 MET n 
1 289 GLY n 
1 290 VAL n 
1 291 PRO n 
1 292 PHE n 
1 293 TYR n 
1 294 GLY n 
1 295 ARG n 
1 296 ALA n 
1 297 PHE n 
1 298 LYS n 
1 299 GLY n 
1 300 VAL n 
1 301 SER n 
1 302 GLY n 
1 303 GLY n 
1 304 ASN n 
1 305 GLY n 
1 306 GLY n 
1 307 GLN n 
1 308 TYR n 
1 309 SER n 
1 310 SER n 
1 311 HIS n 
1 312 SER n 
1 313 THR n 
1 314 PRO n 
1 315 GLY n 
1 316 GLU n 
1 317 ASP n 
1 318 PRO n 
1 319 TYR n 
1 320 PRO n 
1 321 ASN n 
1 322 ALA n 
1 323 ASP n 
1 324 TYR n 
1 325 TRP n 
1 326 LEU n 
1 327 VAL n 
1 328 GLY n 
1 329 CYS n 
1 330 ASP n 
1 331 GLU n 
1 332 CYS n 
1 333 VAL n 
1 334 ARG n 
1 335 ASP n 
1 336 LYS n 
1 337 ASP n 
1 338 PRO n 
1 339 ARG n 
1 340 ILE n 
1 341 ALA n 
1 342 SER n 
1 343 TYR n 
1 344 ARG n 
1 345 GLN n 
1 346 LEU n 
1 347 GLU n 
1 348 GLN n 
1 349 MET n 
1 350 LEU n 
1 351 GLN n 
1 352 GLY n 
1 353 ASN n 
1 354 TYR n 
1 355 GLY n 
1 356 TYR n 
1 357 GLN n 
1 358 ARG n 
1 359 LEU n 
1 360 TRP n 
1 361 ASN n 
1 362 ASP n 
1 363 LYS n 
1 364 THR n 
1 365 LYS n 
1 366 THR n 
1 367 PRO n 
1 368 TYR n 
1 369 LEU n 
1 370 TYR n 
1 371 HIS n 
1 372 ALA n 
1 373 GLN n 
1 374 ASN n 
1 375 GLY n 
1 376 LEU n 
1 377 PHE n 
1 378 VAL n 
1 379 THR n 
1 380 TYR n 
1 381 ASP n 
1 382 ASP n 
1 383 ALA n 
1 384 GLU n 
1 385 SER n 
1 386 PHE n 
1 387 LYS n 
1 388 TYR n 
1 389 LYS n 
1 390 ALA n 
1 391 LYS n 
1 392 TYR n 
1 393 ILE n 
1 394 LYS n 
1 395 GLN n 
1 396 GLN n 
1 397 GLN n 
1 398 LEU n 
1 399 GLY n 
1 400 GLY n 
1 401 VAL n 
1 402 MET n 
1 403 PHE n 
1 404 TRP n 
1 405 HIS n 
1 406 LEU n 
1 407 GLY n 
1 408 GLN n 
1 409 ASP n 
1 410 ASN n 
1 411 ARG n 
1 412 ASN n 
1 413 GLY n 
1 414 ASP n 
1 415 LEU n 
1 416 LEU n 
1 417 ALA n 
1 418 ALA n 
1 419 LEU n 
1 420 ASP n 
1 421 ARG n 
1 422 TYR n 
1 423 PHE n 
1 424 ASN n 
1 425 ALA n 
1 426 ALA n 
1 427 ASP n 
1 428 TYR n 
1 429 ASP n 
1 430 ASP n 
1 431 SER n 
1 432 GLN n 
1 433 LEU n 
1 434 ASP n 
1 435 MET n 
1 436 GLY n 
1 437 THR n 
1 438 GLY n 
1 439 LEU n 
1 440 ARG n 
1 441 TYR n 
1 442 THR n 
1 443 GLY n 
1 444 VAL n 
1 445 GLY n 
1 446 PRO n 
1 447 GLY n 
1 448 ASN n 
1 449 LEU n 
1 450 PRO n 
1 451 ILE n 
1 452 MET n 
1 453 THR n 
1 454 ALA n 
1 455 PRO n 
1 456 ALA n 
1 457 TYR n 
1 458 VAL n 
1 459 PRO n 
1 460 GLY n 
1 461 THR n 
1 462 THR n 
1 463 TYR n 
1 464 ALA n 
1 465 GLN n 
1 466 GLY n 
1 467 ALA n 
1 468 LEU n 
1 469 VAL n 
1 470 SER n 
1 471 TYR n 
1 472 GLN n 
1 473 GLY n 
1 474 TYR n 
1 475 VAL n 
1 476 TRP n 
1 477 GLN n 
1 478 THR n 
1 479 LYS n 
1 480 TRP n 
1 481 GLY n 
1 482 TYR n 
1 483 ILE n 
1 484 THR n 
1 485 SER n 
1 486 ALA n 
1 487 PRO n 
1 488 GLY n 
1 489 SER n 
1 490 ASP n 
1 491 SER n 
1 492 ALA n 
1 493 TRP n 
1 494 LEU n 
1 495 LYS n 
1 496 VAL n 
1 497 GLY n 
1 498 ARG n 
1 499 LEU n 
1 500 ALA n 
1 501 ALA n 
1 502 ALA n 
1 503 ALA n 
1 504 LEU n 
1 505 GLU n 
1 506 HIS n 
1 507 HIS n 
1 508 HIS n 
1 509 HIS n 
1 510 HIS n 
1 511 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   511 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 chiB 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    QMB1466 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Serratia marcescens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     615 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       'pET22b(+)' 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACT non-polymer         . 'ACETATE ION'   ?                               'C2 H3 O2 -1'    59.044  
ALA 'L-peptide linking' y ALANINE         ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                               'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                               'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL        'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE       ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                               'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION' ?                               'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE         ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   0   ?   ?   ?   A . n 
A 1 2   ASP 2   1   ?   ?   ?   A . n 
A 1 3   SER 3   2   2   SER SER A . n 
A 1 4   THR 4   3   3   THR THR A . n 
A 1 5   ARG 5   4   4   ARG ARG A . n 
A 1 6   LYS 6   5   5   LYS LYS A . n 
A 1 7   ALA 7   6   6   ALA ALA A . n 
A 1 8   VAL 8   7   7   VAL VAL A . n 
A 1 9   ILE 9   8   8   ILE ILE A . n 
A 1 10  GLY 10  9   9   GLY GLY A . n 
A 1 11  TYR 11  10  10  TYR TYR A . n 
A 1 12  TYR 12  11  11  TYR TYR A . n 
A 1 13  PHE 13  12  12  PHE PHE A . n 
A 1 14  ILE 14  13  13  ILE ILE A . n 
A 1 15  PRO 15  14  14  PRO PRO A . n 
A 1 16  THR 16  15  15  THR THR A . n 
A 1 17  ASN 17  16  16  ASN ASN A . n 
A 1 18  GLN 18  17  17  GLN GLN A . n 
A 1 19  ILE 19  18  18  ILE ILE A . n 
A 1 20  ASN 20  19  19  ASN ASN A . n 
A 1 21  ASN 21  20  20  ASN ASN A . n 
A 1 22  TYR 22  21  21  TYR TYR A . n 
A 1 23  THR 23  22  22  THR THR A . n 
A 1 24  GLU 24  23  23  GLU GLU A . n 
A 1 25  THR 25  24  24  THR THR A . n 
A 1 26  ASP 26  25  25  ASP ASP A . n 
A 1 27  THR 27  26  26  THR THR A . n 
A 1 28  SER 28  27  27  SER SER A . n 
A 1 29  VAL 29  28  28  VAL VAL A . n 
A 1 30  VAL 30  29  29  VAL VAL A . n 
A 1 31  PRO 31  30  30  PRO PRO A . n 
A 1 32  PHE 32  31  31  PHE PHE A . n 
A 1 33  PRO 33  32  32  PRO PRO A . n 
A 1 34  VAL 34  33  33  VAL VAL A . n 
A 1 35  SER 35  34  34  SER SER A . n 
A 1 36  ASN 36  35  35  ASN ASN A . n 
A 1 37  ILE 37  36  36  ILE ILE A . n 
A 1 38  THR 38  37  37  THR THR A . n 
A 1 39  PRO 39  38  38  PRO PRO A . n 
A 1 40  ALA 40  39  39  ALA ALA A . n 
A 1 41  LYS 41  40  40  LYS LYS A . n 
A 1 42  ALA 42  41  41  ALA ALA A . n 
A 1 43  LYS 43  42  42  LYS LYS A . n 
A 1 44  GLN 44  43  43  GLN GLN A . n 
A 1 45  LEU 45  44  44  LEU LEU A . n 
A 1 46  THR 46  45  45  THR THR A . n 
A 1 47  HIS 47  46  46  HIS HIS A . n 
A 1 48  ILE 48  47  47  ILE ILE A . n 
A 1 49  ASN 49  48  48  ASN ASN A . n 
A 1 50  PHE 50  49  49  PHE PHE A . n 
A 1 51  SER 51  50  50  SER SER A . n 
A 1 52  PHE 52  51  51  PHE PHE A . n 
A 1 53  LEU 53  52  52  LEU LEU A . n 
A 1 54  ASP 54  53  53  ASP ASP A . n 
A 1 55  ILE 55  54  54  ILE ILE A . n 
A 1 56  ASN 56  55  55  ASN ASN A . n 
A 1 57  SER 57  56  56  SER SER A . n 
A 1 58  ASN 58  57  57  ASN ASN A . n 
A 1 59  LEU 59  58  58  LEU LEU A . n 
A 1 60  GLU 60  59  59  GLU GLU A . n 
A 1 61  CYS 61  60  60  CYS CYS A . n 
A 1 62  ALA 62  61  61  ALA ALA A . n 
A 1 63  TRP 63  62  62  TRP TRP A . n 
A 1 64  ASP 64  63  63  ASP ASP A . n 
A 1 65  PRO 65  64  64  PRO PRO A . n 
A 1 66  ALA 66  65  65  ALA ALA A . n 
A 1 67  THR 67  66  66  THR THR A . n 
A 1 68  ASN 68  67  67  ASN ASN A . n 
A 1 69  ASP 69  68  68  ASP ASP A . n 
A 1 70  ALA 70  69  69  ALA ALA A . n 
A 1 71  LYS 71  70  70  LYS LYS A . n 
A 1 72  ALA 72  71  71  ALA ALA A . n 
A 1 73  ARG 73  72  72  ARG ARG A . n 
A 1 74  ASP 74  73  73  ASP ASP A . n 
A 1 75  VAL 75  74  74  VAL VAL A . n 
A 1 76  VAL 76  75  75  VAL VAL A . n 
A 1 77  ASN 77  76  76  ASN ASN A . n 
A 1 78  ARG 78  77  77  ARG ARG A . n 
A 1 79  LEU 79  78  78  LEU LEU A . n 
A 1 80  THR 80  79  79  THR THR A . n 
A 1 81  ALA 81  80  80  ALA ALA A . n 
A 1 82  LEU 82  81  81  LEU LEU A . n 
A 1 83  LYS 83  82  82  LYS LYS A . n 
A 1 84  ALA 84  83  83  ALA ALA A . n 
A 1 85  HIS 85  84  84  HIS HIS A . n 
A 1 86  ASN 86  85  85  ASN ASN A . n 
A 1 87  PRO 87  86  86  PRO PRO A . n 
A 1 88  SER 88  87  87  SER SER A . n 
A 1 89  LEU 89  88  88  LEU LEU A . n 
A 1 90  ARG 90  89  89  ARG ARG A . n 
A 1 91  ILE 91  90  90  ILE ILE A . n 
A 1 92  MET 92  91  91  MET MET A . n 
A 1 93  PHE 93  92  92  PHE PHE A . n 
A 1 94  SER 94  93  93  SER SER A . n 
A 1 95  ILE 95  94  94  ILE ILE A . n 
A 1 96  GLY 96  95  95  GLY GLY A . n 
A 1 97  GLY 97  96  96  GLY GLY A . n 
A 1 98  TRP 98  97  97  TRP TRP A . n 
A 1 99  TYR 99  98  98  TYR TYR A . n 
A 1 100 TYR 100 99  99  TYR TYR A . n 
A 1 101 SER 101 100 100 SER SER A . n 
A 1 102 ASN 102 101 101 ASN ASN A . n 
A 1 103 ASP 103 102 102 ASP ASP A . n 
A 1 104 LEU 104 103 103 LEU LEU A . n 
A 1 105 GLY 105 104 104 GLY GLY A . n 
A 1 106 VAL 106 105 105 VAL VAL A . n 
A 1 107 SER 107 106 106 SER SER A . n 
A 1 108 HIS 108 107 107 HIS HIS A . n 
A 1 109 ALA 109 108 108 ALA ALA A . n 
A 1 110 ASN 110 109 109 ASN ASN A . n 
A 1 111 TYR 111 110 110 TYR TYR A . n 
A 1 112 VAL 112 111 111 VAL VAL A . n 
A 1 113 ASN 113 112 112 ASN ASN A . n 
A 1 114 ALA 114 113 113 ALA ALA A . n 
A 1 115 VAL 115 114 114 VAL VAL A . n 
A 1 116 LYS 116 115 115 LYS LYS A . n 
A 1 117 THR 117 116 116 THR THR A . n 
A 1 118 PRO 118 117 117 PRO PRO A . n 
A 1 119 ALA 119 118 118 ALA ALA A . n 
A 1 120 ALA 120 119 119 ALA ALA A . n 
A 1 121 ARG 121 120 120 ARG ARG A . n 
A 1 122 THR 122 121 121 THR THR A . n 
A 1 123 LYS 123 122 122 LYS LYS A . n 
A 1 124 PHE 124 123 123 PHE PHE A . n 
A 1 125 ALA 125 124 124 ALA ALA A . n 
A 1 126 GLN 126 125 125 GLN GLN A . n 
A 1 127 SER 127 126 126 SER SER A . n 
A 1 128 CYS 128 127 127 CYS CYS A . n 
A 1 129 VAL 129 128 128 VAL VAL A . n 
A 1 130 ARG 130 129 129 ARG ARG A . n 
A 1 131 ILE 131 130 130 ILE ILE A . n 
A 1 132 MET 132 131 131 MET MET A . n 
A 1 133 LYS 133 132 132 LYS LYS A . n 
A 1 134 ASP 134 133 133 ASP ASP A . n 
A 1 135 TYR 135 134 134 TYR TYR A . n 
A 1 136 GLY 136 135 135 GLY GLY A . n 
A 1 137 PHE 137 136 136 PHE PHE A . n 
A 1 138 ASP 138 137 137 ASP ASP A . n 
A 1 139 GLY 139 138 138 GLY GLY A . n 
A 1 140 VAL 140 139 139 VAL VAL A . n 
A 1 141 ASP 141 140 140 ASP ASP A . n 
A 1 142 ILE 142 141 141 ILE ILE A . n 
A 1 143 ASP 143 142 142 ASP ASP A . n 
A 1 144 TRP 144 143 143 TRP TRP A . n 
A 1 145 GLU 145 144 144 GLU GLU A . n 
A 1 146 TYR 146 145 145 TYR TYR A . n 
A 1 147 PRO 147 146 146 PRO PRO A . n 
A 1 148 GLN 148 147 147 GLN GLN A . n 
A 1 149 ALA 149 148 148 ALA ALA A . n 
A 1 150 ALA 150 149 149 ALA ALA A . n 
A 1 151 GLU 151 150 150 GLU GLU A . n 
A 1 152 VAL 152 151 151 VAL VAL A . n 
A 1 153 ASP 153 152 152 ASP ASP A . n 
A 1 154 GLY 154 153 153 GLY GLY A . n 
A 1 155 PHE 155 154 154 PHE PHE A . n 
A 1 156 ILE 156 155 155 ILE ILE A . n 
A 1 157 ALA 157 156 156 ALA ALA A . n 
A 1 158 ALA 158 157 157 ALA ALA A . n 
A 1 159 LEU 159 158 158 LEU LEU A . n 
A 1 160 GLN 160 159 159 GLN GLN A . n 
A 1 161 GLU 161 160 160 GLU GLU A . n 
A 1 162 ILE 162 161 161 ILE ILE A . n 
A 1 163 ARG 163 162 162 ARG ARG A . n 
A 1 164 THR 164 163 163 THR THR A . n 
A 1 165 LEU 165 164 164 LEU LEU A . n 
A 1 166 LEU 166 165 165 LEU LEU A . n 
A 1 167 ASN 167 166 166 ASN ASN A . n 
A 1 168 GLN 168 167 167 GLN GLN A . n 
A 1 169 GLN 169 168 168 GLN GLN A . n 
A 1 170 THR 170 169 169 THR THR A . n 
A 1 171 ILE 171 170 170 ILE ILE A . n 
A 1 172 ALA 172 171 171 ALA ALA A . n 
A 1 173 ASP 173 172 172 ASP ASP A . n 
A 1 174 GLY 174 173 173 GLY GLY A . n 
A 1 175 ARG 175 174 174 ARG ARG A . n 
A 1 176 GLN 176 175 175 GLN GLN A . n 
A 1 177 ALA 177 176 176 ALA ALA A . n 
A 1 178 LEU 178 177 177 LEU LEU A . n 
A 1 179 PRO 179 178 178 PRO PRO A . n 
A 1 180 TYR 180 179 179 TYR TYR A . n 
A 1 181 GLN 181 180 180 GLN GLN A . n 
A 1 182 LEU 182 181 181 LEU LEU A . n 
A 1 183 THR 183 182 182 THR THR A . n 
A 1 184 ILE 184 183 183 ILE ILE A . n 
A 1 185 ALA 185 184 184 ALA ALA A . n 
A 1 186 GLY 186 185 185 GLY GLY A . n 
A 1 187 ALA 187 186 186 ALA ALA A . n 
A 1 188 GLY 188 187 187 GLY GLY A . n 
A 1 189 GLY 189 188 188 GLY GLY A . n 
A 1 190 ALA 190 189 189 ALA ALA A . n 
A 1 191 PHE 191 190 190 PHE PHE A . n 
A 1 192 PHE 192 191 191 PHE PHE A . n 
A 1 193 LEU 193 192 192 LEU LEU A . n 
A 1 194 SER 194 193 193 SER SER A . n 
A 1 195 ARG 195 194 194 ARG ARG A . n 
A 1 196 TYR 196 195 195 TYR TYR A . n 
A 1 197 TYR 197 196 196 TYR TYR A . n 
A 1 198 SER 198 197 197 SER SER A . n 
A 1 199 LYS 199 198 198 LYS LYS A . n 
A 1 200 LEU 200 199 199 LEU LEU A . n 
A 1 201 ALA 201 200 200 ALA ALA A . n 
A 1 202 GLN 202 201 201 GLN GLN A . n 
A 1 203 ILE 203 202 202 ILE ILE A . n 
A 1 204 VAL 204 203 203 VAL VAL A . n 
A 1 205 ALA 205 204 204 ALA ALA A . n 
A 1 206 PRO 206 205 205 PRO PRO A . n 
A 1 207 LEU 207 206 206 LEU LEU A . n 
A 1 208 ASP 208 207 207 ASP ASP A . n 
A 1 209 TYR 209 208 208 TYR TYR A . n 
A 1 210 ILE 210 209 209 ILE ILE A . n 
A 1 211 ASN 211 210 210 ASN ASN A . n 
A 1 212 LEU 212 211 211 LEU LEU A . n 
A 1 213 MET 213 212 212 MET MET A . n 
A 1 214 THR 214 213 213 THR THR A . n 
A 1 215 TYR 215 214 214 TYR TYR A . n 
A 1 216 ASP 216 215 215 ASP ASP A . n 
A 1 217 LEU 217 216 216 LEU LEU A . n 
A 1 218 ALA 218 217 217 ALA ALA A . n 
A 1 219 GLY 219 218 218 GLY GLY A . n 
A 1 220 PRO 220 219 219 PRO PRO A . n 
A 1 221 TRP 221 220 220 TRP TRP A . n 
A 1 222 GLU 222 221 221 GLU GLU A . n 
A 1 223 LYS 223 222 222 LYS LYS A . n 
A 1 224 ILE 224 223 223 ILE ILE A . n 
A 1 225 THR 225 224 224 THR THR A . n 
A 1 226 ASN 226 225 225 ASN ASN A . n 
A 1 227 HIS 227 226 226 HIS HIS A . n 
A 1 228 GLN 228 227 227 GLN GLN A . n 
A 1 229 ALA 229 228 228 ALA ALA A . n 
A 1 230 ALA 230 229 229 ALA ALA A . n 
A 1 231 LEU 231 230 230 LEU LEU A . n 
A 1 232 PHE 232 231 231 PHE PHE A . n 
A 1 233 GLY 233 232 232 GLY GLY A . n 
A 1 234 ASP 234 233 233 ASP ASP A . n 
A 1 235 ALA 235 234 234 ALA ALA A . n 
A 1 236 ALA 236 235 235 ALA ALA A . n 
A 1 237 GLY 237 236 236 GLY GLY A . n 
A 1 238 PRO 238 237 237 PRO PRO A . n 
A 1 239 THR 239 238 238 THR THR A . n 
A 1 240 PHE 240 239 239 PHE PHE A . n 
A 1 241 TYR 241 240 240 TYR TYR A . n 
A 1 242 ASN 242 241 241 ASN ASN A . n 
A 1 243 ALA 243 242 242 ALA ALA A . n 
A 1 244 LEU 244 243 243 LEU LEU A . n 
A 1 245 ARG 245 244 244 ARG ARG A . n 
A 1 246 GLU 246 245 245 GLU GLU A . n 
A 1 247 ALA 247 246 246 ALA ALA A . n 
A 1 248 ASN 248 247 247 ASN ASN A . n 
A 1 249 LEU 249 248 248 LEU LEU A . n 
A 1 250 GLY 250 249 249 GLY GLY A . n 
A 1 251 TRP 251 250 250 TRP TRP A . n 
A 1 252 SER 252 251 251 SER SER A . n 
A 1 253 TRP 253 252 252 TRP TRP A . n 
A 1 254 GLU 254 253 253 GLU GLU A . n 
A 1 255 GLU 255 254 254 GLU GLU A . n 
A 1 256 LEU 256 255 255 LEU LEU A . n 
A 1 257 THR 257 256 256 THR THR A . n 
A 1 258 ARG 258 257 257 ARG ARG A . n 
A 1 259 ALA 259 258 258 ALA ALA A . n 
A 1 260 PHE 260 259 259 PHE PHE A . n 
A 1 261 PRO 261 260 260 PRO PRO A . n 
A 1 262 SER 262 261 261 SER SER A . n 
A 1 263 PRO 263 262 262 PRO PRO A . n 
A 1 264 PHE 264 263 263 PHE PHE A . n 
A 1 265 SER 265 264 264 SER SER A . n 
A 1 266 LEU 266 265 265 LEU LEU A . n 
A 1 267 THR 267 266 266 THR THR A . n 
A 1 268 VAL 268 267 267 VAL VAL A . n 
A 1 269 ASP 269 268 268 ASP ASP A . n 
A 1 270 ALA 270 269 269 ALA ALA A . n 
A 1 271 ALA 271 270 270 ALA ALA A . n 
A 1 272 VAL 272 271 271 VAL VAL A . n 
A 1 273 GLN 273 272 272 GLN GLN A . n 
A 1 274 GLN 274 273 273 GLN GLN A . n 
A 1 275 HIS 275 274 274 HIS HIS A . n 
A 1 276 LEU 276 275 275 LEU LEU A . n 
A 1 277 MET 277 276 276 MET MET A . n 
A 1 278 MET 278 277 277 MET MET A . n 
A 1 279 GLU 279 278 278 GLU GLU A . n 
A 1 280 GLY 280 279 279 GLY GLY A . n 
A 1 281 VAL 281 280 280 VAL VAL A . n 
A 1 282 PRO 282 281 281 PRO PRO A . n 
A 1 283 SER 283 282 282 SER SER A . n 
A 1 284 ALA 284 283 283 ALA ALA A . n 
A 1 285 LYS 285 284 284 LYS LYS A . n 
A 1 286 ILE 286 285 285 ILE ILE A . n 
A 1 287 VAL 287 286 286 VAL VAL A . n 
A 1 288 MET 288 287 287 MET MET A . n 
A 1 289 GLY 289 288 288 GLY GLY A . n 
A 1 290 VAL 290 289 289 VAL VAL A . n 
A 1 291 PRO 291 290 290 PRO PRO A . n 
A 1 292 PHE 292 291 291 PHE PHE A . n 
A 1 293 TYR 293 292 292 TYR TYR A . n 
A 1 294 GLY 294 293 293 GLY GLY A . n 
A 1 295 ARG 295 294 294 ARG ARG A . n 
A 1 296 ALA 296 295 295 ALA ALA A . n 
A 1 297 PHE 297 296 296 PHE PHE A . n 
A 1 298 LYS 298 297 297 LYS LYS A . n 
A 1 299 GLY 299 298 298 GLY GLY A . n 
A 1 300 VAL 300 299 299 VAL VAL A . n 
A 1 301 SER 301 300 300 SER SER A . n 
A 1 302 GLY 302 301 301 GLY GLY A . n 
A 1 303 GLY 303 302 302 GLY GLY A . n 
A 1 304 ASN 304 303 303 ASN ASN A . n 
A 1 305 GLY 305 304 304 GLY GLY A . n 
A 1 306 GLY 306 305 305 GLY GLY A . n 
A 1 307 GLN 307 306 306 GLN GLN A . n 
A 1 308 TYR 308 307 307 TYR TYR A . n 
A 1 309 SER 309 308 308 SER SER A . n 
A 1 310 SER 310 309 309 SER SER A . n 
A 1 311 HIS 311 310 310 HIS HIS A . n 
A 1 312 SER 312 311 311 SER SER A . n 
A 1 313 THR 313 312 312 THR THR A . n 
A 1 314 PRO 314 313 313 PRO PRO A . n 
A 1 315 GLY 315 314 314 GLY GLY A . n 
A 1 316 GLU 316 315 315 GLU GLU A . n 
A 1 317 ASP 317 316 316 ASP ASP A . n 
A 1 318 PRO 318 317 317 PRO PRO A . n 
A 1 319 TYR 319 318 318 TYR TYR A . n 
A 1 320 PRO 320 319 319 PRO PRO A . n 
A 1 321 ASN 321 320 320 ASN ASN A . n 
A 1 322 ALA 322 321 321 ALA ALA A . n 
A 1 323 ASP 323 322 322 ASP ASP A . n 
A 1 324 TYR 324 323 323 TYR TYR A . n 
A 1 325 TRP 325 324 324 TRP TRP A . n 
A 1 326 LEU 326 325 325 LEU LEU A . n 
A 1 327 VAL 327 326 326 VAL VAL A . n 
A 1 328 GLY 328 327 327 GLY GLY A . n 
A 1 329 CYS 329 328 328 CYS CYS A . n 
A 1 330 ASP 330 329 329 ASP ASP A . n 
A 1 331 GLU 331 330 330 GLU GLU A . n 
A 1 332 CYS 332 331 331 CYS CYS A . n 
A 1 333 VAL 333 332 332 VAL VAL A . n 
A 1 334 ARG 334 333 333 ARG ARG A . n 
A 1 335 ASP 335 334 334 ASP ASP A . n 
A 1 336 LYS 336 335 335 LYS LYS A . n 
A 1 337 ASP 337 336 336 ASP ASP A . n 
A 1 338 PRO 338 337 337 PRO PRO A . n 
A 1 339 ARG 339 338 338 ARG ARG A . n 
A 1 340 ILE 340 339 339 ILE ILE A . n 
A 1 341 ALA 341 340 340 ALA ALA A . n 
A 1 342 SER 342 341 341 SER SER A . n 
A 1 343 TYR 343 342 342 TYR TYR A . n 
A 1 344 ARG 344 343 343 ARG ARG A . n 
A 1 345 GLN 345 344 344 GLN GLN A . n 
A 1 346 LEU 346 345 345 LEU LEU A . n 
A 1 347 GLU 347 346 346 GLU GLU A . n 
A 1 348 GLN 348 347 347 GLN GLN A . n 
A 1 349 MET 349 348 348 MET MET A . n 
A 1 350 LEU 350 349 349 LEU LEU A . n 
A 1 351 GLN 351 350 350 GLN GLN A . n 
A 1 352 GLY 352 351 351 GLY GLY A . n 
A 1 353 ASN 353 352 352 ASN ASN A . n 
A 1 354 TYR 354 353 353 TYR TYR A . n 
A 1 355 GLY 355 354 354 GLY GLY A . n 
A 1 356 TYR 356 355 355 TYR TYR A . n 
A 1 357 GLN 357 356 356 GLN GLN A . n 
A 1 358 ARG 358 357 357 ARG ARG A . n 
A 1 359 LEU 359 358 358 LEU LEU A . n 
A 1 360 TRP 360 359 359 TRP TRP A . n 
A 1 361 ASN 361 360 360 ASN ASN A . n 
A 1 362 ASP 362 361 361 ASP ASP A . n 
A 1 363 LYS 363 362 362 LYS LYS A . n 
A 1 364 THR 364 363 363 THR THR A . n 
A 1 365 LYS 365 364 364 LYS LYS A . n 
A 1 366 THR 366 365 365 THR THR A . n 
A 1 367 PRO 367 366 366 PRO PRO A . n 
A 1 368 TYR 368 367 367 TYR TYR A . n 
A 1 369 LEU 369 368 368 LEU LEU A . n 
A 1 370 TYR 370 369 369 TYR TYR A . n 
A 1 371 HIS 371 370 370 HIS HIS A . n 
A 1 372 ALA 372 371 371 ALA ALA A . n 
A 1 373 GLN 373 372 372 GLN GLN A . n 
A 1 374 ASN 374 373 373 ASN ASN A . n 
A 1 375 GLY 375 374 374 GLY GLY A . n 
A 1 376 LEU 376 375 375 LEU LEU A . n 
A 1 377 PHE 377 376 376 PHE PHE A . n 
A 1 378 VAL 378 377 377 VAL VAL A . n 
A 1 379 THR 379 378 378 THR THR A . n 
A 1 380 TYR 380 379 379 TYR TYR A . n 
A 1 381 ASP 381 380 380 ASP ASP A . n 
A 1 382 ASP 382 381 381 ASP ASP A . n 
A 1 383 ALA 383 382 382 ALA ALA A . n 
A 1 384 GLU 384 383 383 GLU GLU A . n 
A 1 385 SER 385 384 384 SER SER A . n 
A 1 386 PHE 386 385 385 PHE PHE A . n 
A 1 387 LYS 387 386 386 LYS LYS A . n 
A 1 388 TYR 388 387 387 TYR TYR A . n 
A 1 389 LYS 389 388 388 LYS LYS A . n 
A 1 390 ALA 390 389 389 ALA ALA A . n 
A 1 391 LYS 391 390 390 LYS LYS A . n 
A 1 392 TYR 392 391 391 TYR TYR A . n 
A 1 393 ILE 393 392 392 ILE ILE A . n 
A 1 394 LYS 394 393 393 LYS LYS A . n 
A 1 395 GLN 395 394 394 GLN GLN A . n 
A 1 396 GLN 396 395 395 GLN GLN A . n 
A 1 397 GLN 397 396 396 GLN GLN A . n 
A 1 398 LEU 398 397 397 LEU LEU A . n 
A 1 399 GLY 399 398 398 GLY GLY A . n 
A 1 400 GLY 400 399 399 GLY GLY A . n 
A 1 401 VAL 401 400 400 VAL VAL A . n 
A 1 402 MET 402 401 401 MET MET A . n 
A 1 403 PHE 403 402 402 PHE PHE A . n 
A 1 404 TRP 404 403 403 TRP TRP A . n 
A 1 405 HIS 405 404 404 HIS HIS A . n 
A 1 406 LEU 406 405 405 LEU LEU A . n 
A 1 407 GLY 407 406 406 GLY GLY A . n 
A 1 408 GLN 408 407 407 GLN GLN A . n 
A 1 409 ASP 409 408 408 ASP ASP A . n 
A 1 410 ASN 410 409 409 ASN ASN A . n 
A 1 411 ARG 411 410 410 ARG ARG A . n 
A 1 412 ASN 412 411 411 ASN ASN A . n 
A 1 413 GLY 413 412 412 GLY GLY A . n 
A 1 414 ASP 414 413 413 ASP ASP A . n 
A 1 415 LEU 415 414 414 LEU LEU A . n 
A 1 416 LEU 416 415 415 LEU LEU A . n 
A 1 417 ALA 417 416 416 ALA ALA A . n 
A 1 418 ALA 418 417 417 ALA ALA A . n 
A 1 419 LEU 419 418 418 LEU LEU A . n 
A 1 420 ASP 420 419 419 ASP ASP A . n 
A 1 421 ARG 421 420 420 ARG ARG A . n 
A 1 422 TYR 422 421 421 TYR TYR A . n 
A 1 423 PHE 423 422 422 PHE PHE A . n 
A 1 424 ASN 424 423 423 ASN ASN A . n 
A 1 425 ALA 425 424 424 ALA ALA A . n 
A 1 426 ALA 426 425 425 ALA ALA A . n 
A 1 427 ASP 427 426 426 ASP ASP A . n 
A 1 428 TYR 428 427 427 TYR TYR A . n 
A 1 429 ASP 429 428 428 ASP ASP A . n 
A 1 430 ASP 430 429 429 ASP ASP A . n 
A 1 431 SER 431 430 430 SER SER A . n 
A 1 432 GLN 432 431 431 GLN GLN A . n 
A 1 433 LEU 433 432 432 LEU LEU A . n 
A 1 434 ASP 434 433 433 ASP ASP A . n 
A 1 435 MET 435 434 434 MET MET A . n 
A 1 436 GLY 436 435 435 GLY GLY A . n 
A 1 437 THR 437 436 436 THR THR A . n 
A 1 438 GLY 438 437 437 GLY GLY A . n 
A 1 439 LEU 439 438 438 LEU LEU A . n 
A 1 440 ARG 440 439 439 ARG ARG A . n 
A 1 441 TYR 441 440 440 TYR TYR A . n 
A 1 442 THR 442 441 441 THR THR A . n 
A 1 443 GLY 443 442 442 GLY GLY A . n 
A 1 444 VAL 444 443 443 VAL VAL A . n 
A 1 445 GLY 445 444 444 GLY GLY A . n 
A 1 446 PRO 446 445 445 PRO PRO A . n 
A 1 447 GLY 447 446 446 GLY GLY A . n 
A 1 448 ASN 448 447 447 ASN ASN A . n 
A 1 449 LEU 449 448 448 LEU LEU A . n 
A 1 450 PRO 450 449 449 PRO PRO A . n 
A 1 451 ILE 451 450 450 ILE ILE A . n 
A 1 452 MET 452 451 451 MET MET A . n 
A 1 453 THR 453 452 452 THR THR A . n 
A 1 454 ALA 454 453 453 ALA ALA A . n 
A 1 455 PRO 455 454 454 PRO PRO A . n 
A 1 456 ALA 456 455 455 ALA ALA A . n 
A 1 457 TYR 457 456 456 TYR TYR A . n 
A 1 458 VAL 458 457 457 VAL VAL A . n 
A 1 459 PRO 459 458 458 PRO PRO A . n 
A 1 460 GLY 460 459 459 GLY GLY A . n 
A 1 461 THR 461 460 460 THR THR A . n 
A 1 462 THR 462 461 461 THR THR A . n 
A 1 463 TYR 463 462 462 TYR TYR A . n 
A 1 464 ALA 464 463 463 ALA ALA A . n 
A 1 465 GLN 465 464 464 GLN GLN A . n 
A 1 466 GLY 466 465 465 GLY GLY A . n 
A 1 467 ALA 467 466 466 ALA ALA A . n 
A 1 468 LEU 468 467 467 LEU LEU A . n 
A 1 469 VAL 469 468 468 VAL VAL A . n 
A 1 470 SER 470 469 469 SER SER A . n 
A 1 471 TYR 471 470 470 TYR TYR A . n 
A 1 472 GLN 472 471 471 GLN GLN A . n 
A 1 473 GLY 473 472 472 GLY GLY A . n 
A 1 474 TYR 474 473 473 TYR TYR A . n 
A 1 475 VAL 475 474 474 VAL VAL A . n 
A 1 476 TRP 476 475 475 TRP TRP A . n 
A 1 477 GLN 477 476 476 GLN GLN A . n 
A 1 478 THR 478 477 477 THR THR A . n 
A 1 479 LYS 479 478 478 LYS LYS A . n 
A 1 480 TRP 480 479 479 TRP TRP A . n 
A 1 481 GLY 481 480 480 GLY GLY A . n 
A 1 482 TYR 482 481 481 TYR TYR A . n 
A 1 483 ILE 483 482 482 ILE ILE A . n 
A 1 484 THR 484 483 483 THR THR A . n 
A 1 485 SER 485 484 484 SER SER A . n 
A 1 486 ALA 486 485 485 ALA ALA A . n 
A 1 487 PRO 487 486 486 PRO PRO A . n 
A 1 488 GLY 488 487 487 GLY GLY A . n 
A 1 489 SER 489 488 488 SER SER A . n 
A 1 490 ASP 490 489 489 ASP ASP A . n 
A 1 491 SER 491 490 490 SER SER A . n 
A 1 492 ALA 492 491 491 ALA ALA A . n 
A 1 493 TRP 493 492 492 TRP TRP A . n 
A 1 494 LEU 494 493 493 LEU LEU A . n 
A 1 495 LYS 495 494 494 LYS LYS A . n 
A 1 496 VAL 496 495 495 VAL VAL A . n 
A 1 497 GLY 497 496 496 GLY GLY A . n 
A 1 498 ARG 498 497 497 ARG ARG A . n 
A 1 499 LEU 499 498 498 LEU LEU A . n 
A 1 500 ALA 500 499 ?   ?   ?   A . n 
A 1 501 ALA 501 500 ?   ?   ?   A . n 
A 1 502 ALA 502 501 ?   ?   ?   A . n 
A 1 503 ALA 503 502 ?   ?   ?   A . n 
A 1 504 LEU 504 503 ?   ?   ?   A . n 
A 1 505 GLU 505 504 ?   ?   ?   A . n 
A 1 506 HIS 506 505 ?   ?   ?   A . n 
A 1 507 HIS 507 506 ?   ?   ?   A . n 
A 1 508 HIS 508 507 ?   ?   ?   A . n 
A 1 509 HIS 509 508 ?   ?   ?   A . n 
A 1 510 HIS 510 509 ?   ?   ?   A . n 
A 1 511 HIS 511 510 ?   ?   ?   A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B  2 GOL 1   601  502 GOL GOL A . 
C  2 GOL 1   602  503 GOL GOL A . 
D  2 GOL 1   603  510 GOL GOL A . 
E  3 ACT 1   604  511 ACT ACT A . 
F  2 GOL 1   605  512 GOL GOL A . 
G  2 GOL 1   606  513 GOL GOL A . 
H  2 GOL 1   607  514 GOL GOL A . 
I  3 ACT 1   608  515 ACT ACT A . 
J  4 PO4 1   609  521 PO4 PO4 A . 
K  2 GOL 1   610  522 GOL GOL A . 
L  2 GOL 1   611  523 GOL GOL A . 
M  2 GOL 1   612  524 GOL GOL A . 
N  4 PO4 1   613  525 PO4 PO4 A . 
O  2 GOL 1   614  526 GOL GOL A . 
P  2 GOL 1   615  528 GOL GOL A . 
Q  2 GOL 1   616  529 GOL GOL A . 
R  4 PO4 1   617  531 PO4 PO4 A . 
S  2 GOL 1   618  539 GOL GOL A . 
T  2 GOL 1   619  540 GOL GOL A . 
U  2 GOL 1   620  544 GOL GOL A . 
V  2 GOL 1   621  546 GOL GOL A . 
W  4 PO4 1   622  549 PO4 PO4 A . 
X  2 GOL 1   623  550 GOL GOL A . 
Y  2 GOL 1   624  554 GOL GOL A . 
Z  2 GOL 1   625  555 GOL GOL A . 
AA 2 GOL 1   626  556 GOL GOL A . 
BA 2 GOL 1   627  557 GOL GOL A . 
CA 2 GOL 1   628  558 GOL GOL A . 
DA 2 GOL 1   629  559 GOL GOL A . 
EA 2 GOL 1   630  561 GOL GOL A . 
FA 2 GOL 1   631  562 GOL GOL A . 
GA 2 GOL 1   632  565 GOL GOL A . 
HA 2 GOL 1   633  566 GOL GOL A . 
IA 3 ACT 1   634  570 ACT ACT A . 
JA 3 ACT 1   635  571 ACT ACT A . 
KA 3 ACT 1   636  572 ACT ACT A . 
LA 3 ACT 1   637  573 ACT ACT A . 
MA 3 ACT 1   638  574 ACT ACT A . 
NA 3 ACT 1   639  575 ACT ACT A . 
OA 3 ACT 1   640  576 ACT ACT A . 
PA 3 ACT 1   641  577 ACT ACT A . 
QA 3 ACT 1   642  578 ACT ACT A . 
RA 3 ACT 1   643  579 ACT ACT A . 
SA 3 ACT 1   644  580 ACT ACT A . 
TA 3 ACT 1   645  581 ACT ACT A . 
UA 3 ACT 1   646  582 ACT ACT A . 
VA 2 GOL 1   647  1   GOL GOL A . 
WA 2 GOL 1   648  2   GOL GOL A . 
XA 2 GOL 1   649  3   GOL GOL A . 
YA 2 GOL 1   650  6   GOL GOL A . 
ZA 2 GOL 1   651  7   GOL GOL A . 
AB 2 GOL 1   652  798 GOL GOL A . 
BB 2 GOL 1   653  799 GOL GOL A . 
CB 2 GOL 1   654  800 GOL GOL A . 
DB 3 ACT 1   655  798 ACT ACT A . 
EB 5 HOH 1   701  571 HOH HOH A . 
EB 5 HOH 2   702  27  HOH HOH A . 
EB 5 HOH 3   703  72  HOH HOH A . 
EB 5 HOH 4   704  386 HOH HOH A . 
EB 5 HOH 5   705  517 HOH HOH A . 
EB 5 HOH 6   706  623 HOH HOH A . 
EB 5 HOH 7   707  264 HOH HOH A . 
EB 5 HOH 8   708  57  HOH HOH A . 
EB 5 HOH 9   709  85  HOH HOH A . 
EB 5 HOH 10  710  621 HOH HOH A . 
EB 5 HOH 11  711  4   HOH HOH A . 
EB 5 HOH 12  712  117 HOH HOH A . 
EB 5 HOH 13  713  56  HOH HOH A . 
EB 5 HOH 14  714  580 HOH HOH A . 
EB 5 HOH 15  715  467 HOH HOH A . 
EB 5 HOH 16  716  669 HOH HOH A . 
EB 5 HOH 17  717  20  HOH HOH A . 
EB 5 HOH 18  718  582 HOH HOH A . 
EB 5 HOH 19  719  724 HOH HOH A . 
EB 5 HOH 20  720  164 HOH HOH A . 
EB 5 HOH 21  721  189 HOH HOH A . 
EB 5 HOH 22  722  159 HOH HOH A . 
EB 5 HOH 23  723  116 HOH HOH A . 
EB 5 HOH 24  724  105 HOH HOH A . 
EB 5 HOH 25  725  48  HOH HOH A . 
EB 5 HOH 26  726  119 HOH HOH A . 
EB 5 HOH 27  727  692 HOH HOH A . 
EB 5 HOH 28  728  83  HOH HOH A . 
EB 5 HOH 29  729  402 HOH HOH A . 
EB 5 HOH 30  730  201 HOH HOH A . 
EB 5 HOH 31  731  209 HOH HOH A . 
EB 5 HOH 32  732  149 HOH HOH A . 
EB 5 HOH 33  733  302 HOH HOH A . 
EB 5 HOH 34  734  73  HOH HOH A . 
EB 5 HOH 35  735  495 HOH HOH A . 
EB 5 HOH 36  736  376 HOH HOH A . 
EB 5 HOH 37  737  625 HOH HOH A . 
EB 5 HOH 38  738  282 HOH HOH A . 
EB 5 HOH 39  739  343 HOH HOH A . 
EB 5 HOH 40  740  366 HOH HOH A . 
EB 5 HOH 41  741  274 HOH HOH A . 
EB 5 HOH 42  742  55  HOH HOH A . 
EB 5 HOH 43  743  21  HOH HOH A . 
EB 5 HOH 44  744  180 HOH HOH A . 
EB 5 HOH 45  745  114 HOH HOH A . 
EB 5 HOH 46  746  33  HOH HOH A . 
EB 5 HOH 47  747  120 HOH HOH A . 
EB 5 HOH 48  748  273 HOH HOH A . 
EB 5 HOH 49  749  394 HOH HOH A . 
EB 5 HOH 50  750  327 HOH HOH A . 
EB 5 HOH 51  751  220 HOH HOH A . 
EB 5 HOH 52  752  288 HOH HOH A . 
EB 5 HOH 53  753  504 HOH HOH A . 
EB 5 HOH 54  754  84  HOH HOH A . 
EB 5 HOH 55  755  397 HOH HOH A . 
EB 5 HOH 56  756  649 HOH HOH A . 
EB 5 HOH 57  757  531 HOH HOH A . 
EB 5 HOH 58  758  120 HOH HOH A . 
EB 5 HOH 59  759  28  HOH HOH A . 
EB 5 HOH 60  760  233 HOH HOH A . 
EB 5 HOH 61  761  289 HOH HOH A . 
EB 5 HOH 62  762  420 HOH HOH A . 
EB 5 HOH 63  763  321 HOH HOH A . 
EB 5 HOH 64  764  221 HOH HOH A . 
EB 5 HOH 65  765  396 HOH HOH A . 
EB 5 HOH 66  766  367 HOH HOH A . 
EB 5 HOH 67  767  54  HOH HOH A . 
EB 5 HOH 68  768  194 HOH HOH A . 
EB 5 HOH 69  769  108 HOH HOH A . 
EB 5 HOH 70  770  465 HOH HOH A . 
EB 5 HOH 71  771  42  HOH HOH A . 
EB 5 HOH 72  772  427 HOH HOH A . 
EB 5 HOH 73  773  82  HOH HOH A . 
EB 5 HOH 74  774  2   HOH HOH A . 
EB 5 HOH 75  775  168 HOH HOH A . 
EB 5 HOH 76  776  230 HOH HOH A . 
EB 5 HOH 77  777  287 HOH HOH A . 
EB 5 HOH 78  778  477 HOH HOH A . 
EB 5 HOH 79  779  50  HOH HOH A . 
EB 5 HOH 80  780  156 HOH HOH A . 
EB 5 HOH 81  781  663 HOH HOH A . 
EB 5 HOH 82  782  104 HOH HOH A . 
EB 5 HOH 83  783  69  HOH HOH A . 
EB 5 HOH 84  784  389 HOH HOH A . 
EB 5 HOH 85  785  466 HOH HOH A . 
EB 5 HOH 86  786  196 HOH HOH A . 
EB 5 HOH 87  787  265 HOH HOH A . 
EB 5 HOH 88  788  685 HOH HOH A . 
EB 5 HOH 89  789  45  HOH HOH A . 
EB 5 HOH 90  790  53  HOH HOH A . 
EB 5 HOH 91  791  433 HOH HOH A . 
EB 5 HOH 92  792  441 HOH HOH A . 
EB 5 HOH 93  793  270 HOH HOH A . 
EB 5 HOH 94  794  593 HOH HOH A . 
EB 5 HOH 95  795  173 HOH HOH A . 
EB 5 HOH 96  796  77  HOH HOH A . 
EB 5 HOH 97  797  101 HOH HOH A . 
EB 5 HOH 98  798  207 HOH HOH A . 
EB 5 HOH 99  799  96  HOH HOH A . 
EB 5 HOH 100 800  350 HOH HOH A . 
EB 5 HOH 101 801  307 HOH HOH A . 
EB 5 HOH 102 802  80  HOH HOH A . 
EB 5 HOH 103 803  552 HOH HOH A . 
EB 5 HOH 104 804  6   HOH HOH A . 
EB 5 HOH 105 805  153 HOH HOH A . 
EB 5 HOH 106 806  90  HOH HOH A . 
EB 5 HOH 107 807  349 HOH HOH A . 
EB 5 HOH 108 808  475 HOH HOH A . 
EB 5 HOH 109 809  165 HOH HOH A . 
EB 5 HOH 110 810  292 HOH HOH A . 
EB 5 HOH 111 811  262 HOH HOH A . 
EB 5 HOH 112 812  513 HOH HOH A . 
EB 5 HOH 113 813  112 HOH HOH A . 
EB 5 HOH 114 814  219 HOH HOH A . 
EB 5 HOH 115 815  428 HOH HOH A . 
EB 5 HOH 116 816  384 HOH HOH A . 
EB 5 HOH 117 817  616 HOH HOH A . 
EB 5 HOH 118 818  518 HOH HOH A . 
EB 5 HOH 119 819  417 HOH HOH A . 
EB 5 HOH 120 820  202 HOH HOH A . 
EB 5 HOH 121 821  299 HOH HOH A . 
EB 5 HOH 122 822  70  HOH HOH A . 
EB 5 HOH 123 823  18  HOH HOH A . 
EB 5 HOH 124 824  345 HOH HOH A . 
EB 5 HOH 125 825  575 HOH HOH A . 
EB 5 HOH 126 826  317 HOH HOH A . 
EB 5 HOH 127 827  351 HOH HOH A . 
EB 5 HOH 128 828  364 HOH HOH A . 
EB 5 HOH 129 829  38  HOH HOH A . 
EB 5 HOH 130 830  88  HOH HOH A . 
EB 5 HOH 131 831  24  HOH HOH A . 
EB 5 HOH 132 832  369 HOH HOH A . 
EB 5 HOH 133 833  275 HOH HOH A . 
EB 5 HOH 134 834  766 HOH HOH A . 
EB 5 HOH 135 835  585 HOH HOH A . 
EB 5 HOH 136 836  462 HOH HOH A . 
EB 5 HOH 137 837  98  HOH HOH A . 
EB 5 HOH 138 838  795 HOH HOH A . 
EB 5 HOH 139 839  178 HOH HOH A . 
EB 5 HOH 140 840  620 HOH HOH A . 
EB 5 HOH 141 841  22  HOH HOH A . 
EB 5 HOH 142 842  57  HOH HOH A . 
EB 5 HOH 143 843  141 HOH HOH A . 
EB 5 HOH 144 844  44  HOH HOH A . 
EB 5 HOH 145 845  7   HOH HOH A . 
EB 5 HOH 146 846  326 HOH HOH A . 
EB 5 HOH 147 847  335 HOH HOH A . 
EB 5 HOH 148 848  91  HOH HOH A . 
EB 5 HOH 149 849  229 HOH HOH A . 
EB 5 HOH 150 850  618 HOH HOH A . 
EB 5 HOH 151 851  338 HOH HOH A . 
EB 5 HOH 152 852  388 HOH HOH A . 
EB 5 HOH 153 853  66  HOH HOH A . 
EB 5 HOH 154 854  223 HOH HOH A . 
EB 5 HOH 155 855  641 HOH HOH A . 
EB 5 HOH 156 856  325 HOH HOH A . 
EB 5 HOH 157 857  452 HOH HOH A . 
EB 5 HOH 158 858  597 HOH HOH A . 
EB 5 HOH 159 859  53  HOH HOH A . 
EB 5 HOH 160 860  423 HOH HOH A . 
EB 5 HOH 161 861  624 HOH HOH A . 
EB 5 HOH 162 862  78  HOH HOH A . 
EB 5 HOH 163 863  283 HOH HOH A . 
EB 5 HOH 164 864  93  HOH HOH A . 
EB 5 HOH 165 865  297 HOH HOH A . 
EB 5 HOH 166 866  192 HOH HOH A . 
EB 5 HOH 167 867  95  HOH HOH A . 
EB 5 HOH 168 868  167 HOH HOH A . 
EB 5 HOH 169 869  762 HOH HOH A . 
EB 5 HOH 170 870  75  HOH HOH A . 
EB 5 HOH 171 871  533 HOH HOH A . 
EB 5 HOH 172 872  336 HOH HOH A . 
EB 5 HOH 173 873  39  HOH HOH A . 
EB 5 HOH 174 874  536 HOH HOH A . 
EB 5 HOH 175 875  49  HOH HOH A . 
EB 5 HOH 176 876  62  HOH HOH A . 
EB 5 HOH 177 877  139 HOH HOH A . 
EB 5 HOH 178 878  26  HOH HOH A . 
EB 5 HOH 179 879  41  HOH HOH A . 
EB 5 HOH 180 880  216 HOH HOH A . 
EB 5 HOH 181 881  174 HOH HOH A . 
EB 5 HOH 182 882  21  HOH HOH A . 
EB 5 HOH 183 883  161 HOH HOH A . 
EB 5 HOH 184 884  484 HOH HOH A . 
EB 5 HOH 185 885  204 HOH HOH A . 
EB 5 HOH 186 886  1   HOH HOH A . 
EB 5 HOH 187 887  97  HOH HOH A . 
EB 5 HOH 188 888  92  HOH HOH A . 
EB 5 HOH 189 889  43  HOH HOH A . 
EB 5 HOH 190 890  365 HOH HOH A . 
EB 5 HOH 191 891  143 HOH HOH A . 
EB 5 HOH 192 892  733 HOH HOH A . 
EB 5 HOH 193 893  34  HOH HOH A . 
EB 5 HOH 194 894  324 HOH HOH A . 
EB 5 HOH 195 895  89  HOH HOH A . 
EB 5 HOH 196 896  181 HOH HOH A . 
EB 5 HOH 197 897  382 HOH HOH A . 
EB 5 HOH 198 898  268 HOH HOH A . 
EB 5 HOH 199 899  332 HOH HOH A . 
EB 5 HOH 200 900  528 HOH HOH A . 
EB 5 HOH 201 901  228 HOH HOH A . 
EB 5 HOH 202 902  226 HOH HOH A . 
EB 5 HOH 203 903  563 HOH HOH A . 
EB 5 HOH 204 904  328 HOH HOH A . 
EB 5 HOH 205 905  152 HOH HOH A . 
EB 5 HOH 206 906  109 HOH HOH A . 
EB 5 HOH 207 907  205 HOH HOH A . 
EB 5 HOH 208 908  539 HOH HOH A . 
EB 5 HOH 209 909  609 HOH HOH A . 
EB 5 HOH 210 910  79  HOH HOH A . 
EB 5 HOH 211 911  414 HOH HOH A . 
EB 5 HOH 212 912  11  HOH HOH A . 
EB 5 HOH 213 913  208 HOH HOH A . 
EB 5 HOH 214 914  304 HOH HOH A . 
EB 5 HOH 215 915  236 HOH HOH A . 
EB 5 HOH 216 916  785 HOH HOH A . 
EB 5 HOH 217 917  284 HOH HOH A . 
EB 5 HOH 218 918  107 HOH HOH A . 
EB 5 HOH 219 919  143 HOH HOH A . 
EB 5 HOH 220 920  259 HOH HOH A . 
EB 5 HOH 221 921  250 HOH HOH A . 
EB 5 HOH 222 922  74  HOH HOH A . 
EB 5 HOH 223 923  113 HOH HOH A . 
EB 5 HOH 224 924  64  HOH HOH A . 
EB 5 HOH 225 925  353 HOH HOH A . 
EB 5 HOH 226 926  171 HOH HOH A . 
EB 5 HOH 227 927  35  HOH HOH A . 
EB 5 HOH 228 928  51  HOH HOH A . 
EB 5 HOH 229 929  61  HOH HOH A . 
EB 5 HOH 230 930  94  HOH HOH A . 
EB 5 HOH 231 931  52  HOH HOH A . 
EB 5 HOH 232 932  608 HOH HOH A . 
EB 5 HOH 233 933  58  HOH HOH A . 
EB 5 HOH 234 934  310 HOH HOH A . 
EB 5 HOH 235 935  41  HOH HOH A . 
EB 5 HOH 236 936  151 HOH HOH A . 
EB 5 HOH 237 937  40  HOH HOH A . 
EB 5 HOH 238 938  71  HOH HOH A . 
EB 5 HOH 239 939  89  HOH HOH A . 
EB 5 HOH 240 940  13  HOH HOH A . 
EB 5 HOH 241 941  134 HOH HOH A . 
EB 5 HOH 242 942  256 HOH HOH A . 
EB 5 HOH 243 943  111 HOH HOH A . 
EB 5 HOH 244 944  115 HOH HOH A . 
EB 5 HOH 245 945  234 HOH HOH A . 
EB 5 HOH 246 946  140 HOH HOH A . 
EB 5 HOH 247 947  286 HOH HOH A . 
EB 5 HOH 248 948  12  HOH HOH A . 
EB 5 HOH 249 949  10  HOH HOH A . 
EB 5 HOH 250 950  696 HOH HOH A . 
EB 5 HOH 251 951  68  HOH HOH A . 
EB 5 HOH 252 952  674 HOH HOH A . 
EB 5 HOH 253 953  272 HOH HOH A . 
EB 5 HOH 254 954  377 HOH HOH A . 
EB 5 HOH 255 955  54  HOH HOH A . 
EB 5 HOH 256 956  38  HOH HOH A . 
EB 5 HOH 257 957  276 HOH HOH A . 
EB 5 HOH 258 958  422 HOH HOH A . 
EB 5 HOH 259 959  117 HOH HOH A . 
EB 5 HOH 260 960  592 HOH HOH A . 
EB 5 HOH 261 961  118 HOH HOH A . 
EB 5 HOH 262 962  247 HOH HOH A . 
EB 5 HOH 263 963  578 HOH HOH A . 
EB 5 HOH 264 964  371 HOH HOH A . 
EB 5 HOH 265 965  67  HOH HOH A . 
EB 5 HOH 266 966  347 HOH HOH A . 
EB 5 HOH 267 967  81  HOH HOH A . 
EB 5 HOH 268 968  322 HOH HOH A . 
EB 5 HOH 269 969  19  HOH HOH A . 
EB 5 HOH 270 970  770 HOH HOH A . 
EB 5 HOH 271 971  266 HOH HOH A . 
EB 5 HOH 272 972  515 HOH HOH A . 
EB 5 HOH 273 973  546 HOH HOH A . 
EB 5 HOH 274 974  135 HOH HOH A . 
EB 5 HOH 275 975  686 HOH HOH A . 
EB 5 HOH 276 976  655 HOH HOH A . 
EB 5 HOH 277 977  393 HOH HOH A . 
EB 5 HOH 278 978  23  HOH HOH A . 
EB 5 HOH 279 979  309 HOH HOH A . 
EB 5 HOH 280 980  146 HOH HOH A . 
EB 5 HOH 281 981  102 HOH HOH A . 
EB 5 HOH 282 982  37  HOH HOH A . 
EB 5 HOH 283 983  488 HOH HOH A . 
EB 5 HOH 284 984  225 HOH HOH A . 
EB 5 HOH 285 985  172 HOH HOH A . 
EB 5 HOH 286 986  36  HOH HOH A . 
EB 5 HOH 287 987  160 HOH HOH A . 
EB 5 HOH 288 988  629 HOH HOH A . 
EB 5 HOH 289 989  331 HOH HOH A . 
EB 5 HOH 290 990  362 HOH HOH A . 
EB 5 HOH 291 991  59  HOH HOH A . 
EB 5 HOH 292 992  25  HOH HOH A . 
EB 5 HOH 293 993  320 HOH HOH A . 
EB 5 HOH 294 994  615 HOH HOH A . 
EB 5 HOH 295 995  125 HOH HOH A . 
EB 5 HOH 296 996  130 HOH HOH A . 
EB 5 HOH 297 997  403 HOH HOH A . 
EB 5 HOH 298 998  341 HOH HOH A . 
EB 5 HOH 299 999  206 HOH HOH A . 
EB 5 HOH 300 1000 512 HOH HOH A . 
EB 5 HOH 301 1001 73  HOH HOH A . 
EB 5 HOH 302 1002 69  HOH HOH A . 
EB 5 HOH 303 1003 30  HOH HOH A . 
EB 5 HOH 304 1004 468 HOH HOH A . 
EB 5 HOH 305 1005 222 HOH HOH A . 
EB 5 HOH 306 1006 63  HOH HOH A . 
EB 5 HOH 307 1007 137 HOH HOH A . 
EB 5 HOH 308 1008 72  HOH HOH A . 
EB 5 HOH 309 1009 110 HOH HOH A . 
EB 5 HOH 310 1010 464 HOH HOH A . 
EB 5 HOH 311 1011 702 HOH HOH A . 
EB 5 HOH 312 1012 199 HOH HOH A . 
EB 5 HOH 313 1013 673 HOH HOH A . 
EB 5 HOH 314 1014 553 HOH HOH A . 
EB 5 HOH 315 1015 237 HOH HOH A . 
EB 5 HOH 316 1016 212 HOH HOH A . 
EB 5 HOH 317 1017 500 HOH HOH A . 
EB 5 HOH 318 1018 437 HOH HOH A . 
EB 5 HOH 319 1019 8   HOH HOH A . 
EB 5 HOH 320 1020 29  HOH HOH A . 
EB 5 HOH 321 1021 281 HOH HOH A . 
EB 5 HOH 322 1022 261 HOH HOH A . 
EB 5 HOH 323 1023 133 HOH HOH A . 
EB 5 HOH 324 1024 404 HOH HOH A . 
EB 5 HOH 325 1025 387 HOH HOH A . 
EB 5 HOH 326 1026 16  HOH HOH A . 
EB 5 HOH 327 1027 113 HOH HOH A . 
EB 5 HOH 328 1028 126 HOH HOH A . 
EB 5 HOH 329 1029 185 HOH HOH A . 
EB 5 HOH 330 1030 549 HOH HOH A . 
EB 5 HOH 331 1031 146 HOH HOH A . 
EB 5 HOH 332 1032 780 HOH HOH A . 
EB 5 HOH 333 1033 739 HOH HOH A . 
EB 5 HOH 334 1034 145 HOH HOH A . 
EB 5 HOH 335 1035 81  HOH HOH A . 
EB 5 HOH 336 1036 551 HOH HOH A . 
EB 5 HOH 337 1037 147 HOH HOH A . 
EB 5 HOH 338 1038 106 HOH HOH A . 
EB 5 HOH 339 1039 15  HOH HOH A . 
EB 5 HOH 340 1040 4   HOH HOH A . 
EB 5 HOH 341 1041 14  HOH HOH A . 
EB 5 HOH 342 1042 474 HOH HOH A . 
EB 5 HOH 343 1043 406 HOH HOH A . 
EB 5 HOH 344 1044 200 HOH HOH A . 
EB 5 HOH 345 1045 244 HOH HOH A . 
EB 5 HOH 346 1046 470 HOH HOH A . 
EB 5 HOH 347 1047 379 HOH HOH A . 
EB 5 HOH 348 1048 55  HOH HOH A . 
EB 5 HOH 349 1049 400 HOH HOH A . 
EB 5 HOH 350 1050 395 HOH HOH A . 
EB 5 HOH 351 1051 133 HOH HOH A . 
EB 5 HOH 352 1052 131 HOH HOH A . 
EB 5 HOH 353 1053 193 HOH HOH A . 
EB 5 HOH 354 1054 132 HOH HOH A . 
EB 5 HOH 355 1055 103 HOH HOH A . 
EB 5 HOH 356 1056 175 HOH HOH A . 
EB 5 HOH 357 1057 217 HOH HOH A . 
EB 5 HOH 358 1058 707 HOH HOH A . 
EB 5 HOH 359 1059 2   HOH HOH A . 
EB 5 HOH 360 1060 150 HOH HOH A . 
EB 5 HOH 361 1061 368 HOH HOH A . 
EB 5 HOH 362 1062 643 HOH HOH A . 
EB 5 HOH 363 1063 77  HOH HOH A . 
EB 5 HOH 364 1064 46  HOH HOH A . 
EB 5 HOH 365 1065 138 HOH HOH A . 
EB 5 HOH 366 1066 257 HOH HOH A . 
EB 5 HOH 367 1067 399 HOH HOH A . 
EB 5 HOH 368 1068 410 HOH HOH A . 
EB 5 HOH 369 1069 122 HOH HOH A . 
EB 5 HOH 370 1070 311 HOH HOH A . 
EB 5 HOH 371 1071 60  HOH HOH A . 
EB 5 HOH 372 1072 86  HOH HOH A . 
EB 5 HOH 373 1073 749 HOH HOH A . 
EB 5 HOH 374 1074 330 HOH HOH A . 
EB 5 HOH 375 1075 530 HOH HOH A . 
EB 5 HOH 376 1076 295 HOH HOH A . 
EB 5 HOH 377 1077 296 HOH HOH A . 
EB 5 HOH 378 1078 218 HOH HOH A . 
EB 5 HOH 379 1079 101 HOH HOH A . 
EB 5 HOH 380 1080 163 HOH HOH A . 
EB 5 HOH 381 1081 127 HOH HOH A . 
EB 5 HOH 382 1082 47  HOH HOH A . 
EB 5 HOH 383 1083 516 HOH HOH A . 
EB 5 HOH 384 1084 329 HOH HOH A . 
EB 5 HOH 385 1085 211 HOH HOH A . 
EB 5 HOH 386 1086 214 HOH HOH A . 
EB 5 HOH 387 1087 314 HOH HOH A . 
EB 5 HOH 388 1088 672 HOH HOH A . 
EB 5 HOH 389 1089 179 HOH HOH A . 
EB 5 HOH 390 1090 725 HOH HOH A . 
EB 5 HOH 391 1091 252 HOH HOH A . 
EB 5 HOH 392 1092 157 HOH HOH A . 
EB 5 HOH 393 1093 253 HOH HOH A . 
EB 5 HOH 394 1094 300 HOH HOH A . 
EB 5 HOH 395 1095 709 HOH HOH A . 
EB 5 HOH 396 1096 238 HOH HOH A . 
EB 5 HOH 397 1097 187 HOH HOH A . 
EB 5 HOH 398 1098 303 HOH HOH A . 
EB 5 HOH 399 1099 348 HOH HOH A . 
EB 5 HOH 400 1100 224 HOH HOH A . 
EB 5 HOH 401 1101 374 HOH HOH A . 
EB 5 HOH 402 1102 32  HOH HOH A . 
EB 5 HOH 403 1103 293 HOH HOH A . 
EB 5 HOH 404 1104 425 HOH HOH A . 
EB 5 HOH 405 1105 147 HOH HOH A . 
EB 5 HOH 406 1106 640 HOH HOH A . 
EB 5 HOH 407 1107 455 HOH HOH A . 
EB 5 HOH 408 1108 509 HOH HOH A . 
EB 5 HOH 409 1109 124 HOH HOH A . 
EB 5 HOH 410 1110 162 HOH HOH A . 
EB 5 HOH 411 1111 260 HOH HOH A . 
EB 5 HOH 412 1112 797 HOH HOH A . 
EB 5 HOH 413 1113 411 HOH HOH A . 
EB 5 HOH 414 1114 198 HOH HOH A . 
EB 5 HOH 415 1115 154 HOH HOH A . 
EB 5 HOH 416 1116 169 HOH HOH A . 
EB 5 HOH 417 1117 243 HOH HOH A . 
EB 5 HOH 418 1118 121 HOH HOH A . 
EB 5 HOH 419 1119 239 HOH HOH A . 
EB 5 HOH 420 1120 772 HOH HOH A . 
EB 5 HOH 421 1121 144 HOH HOH A . 
EB 5 HOH 422 1122 14  HOH HOH A . 
EB 5 HOH 423 1123 85  HOH HOH A . 
EB 5 HOH 424 1124 688 HOH HOH A . 
EB 5 HOH 425 1125 182 HOH HOH A . 
EB 5 HOH 426 1126 333 HOH HOH A . 
EB 5 HOH 427 1127 3   HOH HOH A . 
EB 5 HOH 428 1128 446 HOH HOH A . 
EB 5 HOH 429 1129 267 HOH HOH A . 
EB 5 HOH 430 1130 31  HOH HOH A . 
EB 5 HOH 431 1131 473 HOH HOH A . 
EB 5 HOH 432 1132 744 HOH HOH A . 
EB 5 HOH 433 1133 12  HOH HOH A . 
EB 5 HOH 434 1134 158 HOH HOH A . 
EB 5 HOH 435 1135 263 HOH HOH A . 
EB 5 HOH 436 1136 10  HOH HOH A . 
EB 5 HOH 437 1137 542 HOH HOH A . 
EB 5 HOH 438 1138 60  HOH HOH A . 
EB 5 HOH 439 1139 28  HOH HOH A . 
EB 5 HOH 440 1140 339 HOH HOH A . 
EB 5 HOH 441 1141 123 HOH HOH A . 
EB 5 HOH 442 1142 595 HOH HOH A . 
EB 5 HOH 443 1143 20  HOH HOH A . 
EB 5 HOH 444 1144 279 HOH HOH A . 
EB 5 HOH 445 1145 136 HOH HOH A . 
EB 5 HOH 446 1146 502 HOH HOH A . 
EB 5 HOH 447 1147 570 HOH HOH A . 
EB 5 HOH 448 1148 203 HOH HOH A . 
EB 5 HOH 449 1149 781 HOH HOH A . 
EB 5 HOH 450 1150 66  HOH HOH A . 
EB 5 HOH 451 1151 581 HOH HOH A . 
EB 5 HOH 452 1152 448 HOH HOH A . 
EB 5 HOH 453 1153 83  HOH HOH A . 
EB 5 HOH 454 1154 355 HOH HOH A . 
EB 5 HOH 455 1155 432 HOH HOH A . 
EB 5 HOH 456 1156 587 HOH HOH A . 
EB 5 HOH 457 1157 93  HOH HOH A . 
EB 5 HOH 458 1158 128 HOH HOH A . 
EB 5 HOH 459 1159 248 HOH HOH A . 
EB 5 HOH 460 1160 298 HOH HOH A . 
EB 5 HOH 461 1161 197 HOH HOH A . 
EB 5 HOH 462 1162 17  HOH HOH A . 
EB 5 HOH 463 1163 493 HOH HOH A . 
EB 5 HOH 464 1164 129 HOH HOH A . 
EB 5 HOH 465 1165 565 HOH HOH A . 
EB 5 HOH 466 1166 315 HOH HOH A . 
EB 5 HOH 467 1167 794 HOH HOH A . 
EB 5 HOH 468 1168 773 HOH HOH A . 
EB 5 HOH 469 1169 231 HOH HOH A . 
EB 5 HOH 470 1170 447 HOH HOH A . 
EB 5 HOH 471 1171 308 HOH HOH A . 
EB 5 HOH 472 1172 407 HOH HOH A . 
EB 5 HOH 473 1173 24  HOH HOH A . 
EB 5 HOH 474 1174 312 HOH HOH A . 
EB 5 HOH 475 1175 434 HOH HOH A . 
EB 5 HOH 476 1176 131 HOH HOH A . 
EB 5 HOH 477 1177 107 HOH HOH A . 
EB 5 HOH 478 1178 342 HOH HOH A . 
EB 5 HOH 479 1179 721 HOH HOH A . 
EB 5 HOH 480 1180 5   HOH HOH A . 
EB 5 HOH 481 1181 375 HOH HOH A . 
EB 5 HOH 482 1182 99  HOH HOH A . 
EB 5 HOH 483 1183 436 HOH HOH A . 
EB 5 HOH 484 1184 140 HOH HOH A . 
EB 5 HOH 485 1185 112 HOH HOH A . 
EB 5 HOH 486 1186 95  HOH HOH A . 
EB 5 HOH 487 1187 476 HOH HOH A . 
EB 5 HOH 488 1188 569 HOH HOH A . 
EB 5 HOH 489 1189 183 HOH HOH A . 
EB 5 HOH 490 1190 318 HOH HOH A . 
EB 5 HOH 491 1191 177 HOH HOH A . 
EB 5 HOH 492 1192 523 HOH HOH A . 
EB 5 HOH 493 1193 337 HOH HOH A . 
EB 5 HOH 494 1194 783 HOH HOH A . 
EB 5 HOH 495 1195 459 HOH HOH A . 
EB 5 HOH 496 1196 5   HOH HOH A . 
EB 5 HOH 497 1197 498 HOH HOH A . 
EB 5 HOH 498 1198 708 HOH HOH A . 
EB 5 HOH 499 1199 186 HOH HOH A . 
EB 5 HOH 500 1200 541 HOH HOH A . 
EB 5 HOH 501 1201 251 HOH HOH A . 
EB 5 HOH 502 1202 796 HOH HOH A . 
EB 5 HOH 503 1203 35  HOH HOH A . 
EB 5 HOH 504 1204 538 HOH HOH A . 
EB 5 HOH 505 1205 656 HOH HOH A . 
EB 5 HOH 506 1206 316 HOH HOH A . 
EB 5 HOH 507 1207 705 HOH HOH A . 
EB 5 HOH 508 1208 61  HOH HOH A . 
EB 5 HOH 509 1209 511 HOH HOH A . 
EB 5 HOH 510 1210 294 HOH HOH A . 
EB 5 HOH 511 1211 451 HOH HOH A . 
EB 5 HOH 512 1212 573 HOH HOH A . 
EB 5 HOH 513 1213 424 HOH HOH A . 
EB 5 HOH 514 1214 583 HOH HOH A . 
EB 5 HOH 515 1215 381 HOH HOH A . 
EB 5 HOH 516 1216 555 HOH HOH A . 
EB 5 HOH 517 1217 87  HOH HOH A . 
EB 5 HOH 518 1218 558 HOH HOH A . 
EB 5 HOH 519 1219 97  HOH HOH A . 
EB 5 HOH 520 1220 59  HOH HOH A . 
EB 5 HOH 521 1221 628 HOH HOH A . 
EB 5 HOH 522 1222 401 HOH HOH A . 
EB 5 HOH 523 1223 499 HOH HOH A . 
EB 5 HOH 524 1224 534 HOH HOH A . 
EB 5 HOH 525 1225 440 HOH HOH A . 
EB 5 HOH 526 1226 184 HOH HOH A . 
EB 5 HOH 527 1227 269 HOH HOH A . 
EB 5 HOH 528 1228 8   HOH HOH A . 
EB 5 HOH 529 1229 774 HOH HOH A . 
EB 5 HOH 530 1230 134 HOH HOH A . 
EB 5 HOH 531 1231 730 HOH HOH A . 
EB 5 HOH 532 1232 26  HOH HOH A . 
EB 5 HOH 533 1233 524 HOH HOH A . 
EB 5 HOH 534 1234 285 HOH HOH A . 
EB 5 HOH 535 1235 94  HOH HOH A . 
EB 5 HOH 536 1236 408 HOH HOH A . 
EB 5 HOH 537 1237 42  HOH HOH A . 
EB 5 HOH 538 1238 1   HOH HOH A . 
EB 5 HOH 539 1239 449 HOH HOH A . 
EB 5 HOH 540 1240 695 HOH HOH A . 
EB 5 HOH 541 1241 754 HOH HOH A . 
EB 5 HOH 542 1242 142 HOH HOH A . 
EB 5 HOH 543 1243 323 HOH HOH A . 
EB 5 HOH 544 1244 145 HOH HOH A . 
EB 5 HOH 545 1245 659 HOH HOH A . 
EB 5 HOH 546 1246 102 HOH HOH A . 
EB 5 HOH 547 1247 412 HOH HOH A . 
EB 5 HOH 548 1248 746 HOH HOH A . 
EB 5 HOH 549 1249 415 HOH HOH A . 
EB 5 HOH 550 1250 480 HOH HOH A . 
EB 5 HOH 551 1251 110 HOH HOH A . 
EB 5 HOH 552 1252 144 HOH HOH A . 
EB 5 HOH 553 1253 242 HOH HOH A . 
EB 5 HOH 554 1254 277 HOH HOH A . 
EB 5 HOH 555 1255 142 HOH HOH A . 
EB 5 HOH 556 1256 170 HOH HOH A . 
EB 5 HOH 557 1257 139 HOH HOH A . 
EB 5 HOH 558 1258 34  HOH HOH A . 
EB 5 HOH 559 1259 39  HOH HOH A . 
EB 5 HOH 560 1260 119 HOH HOH A . 
EB 5 HOH 561 1261 76  HOH HOH A . 
EB 5 HOH 562 1262 654 HOH HOH A . 
EB 5 HOH 563 1263 98  HOH HOH A . 
EB 5 HOH 564 1264 693 HOH HOH A . 
EB 5 HOH 565 1265 188 HOH HOH A . 
EB 5 HOH 566 1266 421 HOH HOH A . 
EB 5 HOH 567 1267 532 HOH HOH A . 
EB 5 HOH 568 1268 52  HOH HOH A . 
EB 5 HOH 569 1269 418 HOH HOH A . 
EB 5 HOH 570 1270 255 HOH HOH A . 
EB 5 HOH 571 1271 363 HOH HOH A . 
EB 5 HOH 572 1272 99  HOH HOH A . 
EB 5 HOH 573 1273 589 HOH HOH A . 
EB 5 HOH 574 1274 82  HOH HOH A . 
EB 5 HOH 575 1275 67  HOH HOH A . 
EB 5 HOH 576 1276 49  HOH HOH A . 
EB 5 HOH 577 1277 148 HOH HOH A . 
EB 5 HOH 578 1278 497 HOH HOH A . 
EB 5 HOH 579 1279 62  HOH HOH A . 
EB 5 HOH 580 1280 748 HOH HOH A . 
EB 5 HOH 581 1281 658 HOH HOH A . 
EB 5 HOH 582 1282 87  HOH HOH A . 
EB 5 HOH 583 1283 96  HOH HOH A . 
EB 5 HOH 584 1284 727 HOH HOH A . 
EB 5 HOH 585 1285 439 HOH HOH A . 
EB 5 HOH 586 1286 728 HOH HOH A . 
EB 5 HOH 587 1287 490 HOH HOH A . 
EB 5 HOH 588 1288 79  HOH HOH A . 
EB 5 HOH 589 1289 617 HOH HOH A . 
EB 5 HOH 590 1290 596 HOH HOH A . 
EB 5 HOH 591 1291 135 HOH HOH A . 
EB 5 HOH 592 1292 550 HOH HOH A . 
EB 5 HOH 593 1293 280 HOH HOH A . 
EB 5 HOH 594 1294 731 HOH HOH A . 
EB 5 HOH 595 1295 141 HOH HOH A . 
EB 5 HOH 596 1296 319 HOH HOH A . 
EB 5 HOH 597 1297 109 HOH HOH A . 
EB 5 HOH 598 1298 29  HOH HOH A . 
EB 5 HOH 599 1299 506 HOH HOH A . 
EB 5 HOH 600 1300 527 HOH HOH A . 
EB 5 HOH 601 1301 13  HOH HOH A . 
EB 5 HOH 602 1302 195 HOH HOH A . 
EB 5 HOH 603 1303 723 HOH HOH A . 
EB 5 HOH 604 1304 526 HOH HOH A . 
EB 5 HOH 605 1305 111 HOH HOH A . 
EB 5 HOH 606 1306 651 HOH HOH A . 
EB 5 HOH 607 1307 508 HOH HOH A . 
EB 5 HOH 608 1308 684 HOH HOH A . 
EB 5 HOH 609 1309 383 HOH HOH A . 
EB 5 HOH 610 1310 358 HOH HOH A . 
EB 5 HOH 611 1311 735 HOH HOH A . 
EB 5 HOH 612 1312 51  HOH HOH A . 
EB 5 HOH 613 1313 258 HOH HOH A . 
EB 5 HOH 614 1314 599 HOH HOH A . 
EB 5 HOH 615 1315 564 HOH HOH A . 
EB 5 HOH 616 1316 763 HOH HOH A . 
EB 5 HOH 617 1317 103 HOH HOH A . 
EB 5 HOH 618 1318 745 HOH HOH A . 
EB 5 HOH 619 1319 390 HOH HOH A . 
EB 5 HOH 620 1320 758 HOH HOH A . 
EB 5 HOH 621 1321 458 HOH HOH A . 
EB 5 HOH 622 1322 6   HOH HOH A . 
EB 5 HOH 623 1323 25  HOH HOH A . 
EB 5 HOH 624 1324 43  HOH HOH A . 
EB 5 HOH 625 1325 116 HOH HOH A . 
EB 5 HOH 626 1326 776 HOH HOH A . 
EB 5 HOH 627 1327 610 HOH HOH A . 
EB 5 HOH 628 1328 537 HOH HOH A . 
EB 5 HOH 629 1329 313 HOH HOH A . 
EB 5 HOH 630 1330 278 HOH HOH A . 
EB 5 HOH 631 1331 71  HOH HOH A . 
EB 5 HOH 632 1332 638 HOH HOH A . 
EB 5 HOH 633 1333 644 HOH HOH A . 
EB 5 HOH 634 1334 123 HOH HOH A . 
EB 5 HOH 635 1335 633 HOH HOH A . 
EB 5 HOH 636 1336 18  HOH HOH A . 
EB 5 HOH 637 1337 78  HOH HOH A . 
EB 5 HOH 638 1338 235 HOH HOH A . 
EB 5 HOH 639 1339 738 HOH HOH A . 
EB 5 HOH 640 1340 68  HOH HOH A . 
EB 5 HOH 641 1341 86  HOH HOH A . 
EB 5 HOH 642 1342 548 HOH HOH A . 
EB 5 HOH 643 1343 249 HOH HOH A . 
EB 5 HOH 644 1344 591 HOH HOH A . 
EB 5 HOH 645 1345 634 HOH HOH A . 
EB 5 HOH 646 1346 48  HOH HOH A . 
EB 5 HOH 647 1347 430 HOH HOH A . 
EB 5 HOH 648 1348 108 HOH HOH A . 
EB 5 HOH 649 1349 104 HOH HOH A . 
EB 5 HOH 650 1350 777 HOH HOH A . 
EB 5 HOH 651 1351 392 HOH HOH A . 
EB 5 HOH 652 1352 442 HOH HOH A . 
EB 5 HOH 653 1353 305 HOH HOH A . 
EB 5 HOH 654 1354 717 HOH HOH A . 
EB 5 HOH 655 1355 700 HOH HOH A . 
EB 5 HOH 656 1356 7   HOH HOH A . 
EB 5 HOH 657 1357 525 HOH HOH A . 
EB 5 HOH 658 1358 391 HOH HOH A . 
EB 5 HOH 659 1359 626 HOH HOH A . 
EB 5 HOH 660 1360 793 HOH HOH A . 
EB 5 HOH 661 1361 481 HOH HOH A . 
EB 5 HOH 662 1362 471 HOH HOH A . 
EB 5 HOH 663 1363 136 HOH HOH A . 
EB 5 HOH 664 1364 522 HOH HOH A . 
EB 5 HOH 665 1365 80  HOH HOH A . 
EB 5 HOH 666 1366 450 HOH HOH A . 
EB 5 HOH 667 1367 764 HOH HOH A . 
EB 5 HOH 668 1368 290 HOH HOH A . 
EB 5 HOH 669 1369 747 HOH HOH A . 
EB 5 HOH 670 1370 50  HOH HOH A . 
EB 5 HOH 671 1371 378 HOH HOH A . 
EB 5 HOH 672 1372 128 HOH HOH A . 
EB 5 HOH 673 1373 714 HOH HOH A . 
EB 5 HOH 674 1374 461 HOH HOH A . 
EB 5 HOH 675 1375 443 HOH HOH A . 
EB 5 HOH 676 1376 716 HOH HOH A . 
EB 5 HOH 677 1377 65  HOH HOH A . 
EB 5 HOH 678 1378 361 HOH HOH A . 
EB 5 HOH 679 1379 567 HOH HOH A . 
EB 5 HOH 680 1380 17  HOH HOH A . 
EB 5 HOH 681 1381 416 HOH HOH A . 
EB 5 HOH 682 1382 670 HOH HOH A . 
EB 5 HOH 683 1383 637 HOH HOH A . 
EB 5 HOH 684 1384 602 HOH HOH A . 
EB 5 HOH 685 1385 755 HOH HOH A . 
EB 5 HOH 686 1386 245 HOH HOH A . 
EB 5 HOH 687 1387 719 HOH HOH A . 
EB 5 HOH 688 1388 40  HOH HOH A . 
EB 5 HOH 689 1389 519 HOH HOH A . 
EB 5 HOH 690 1390 334 HOH HOH A . 
EB 5 HOH 691 1391 557 HOH HOH A . 
EB 5 HOH 692 1392 445 HOH HOH A . 
EB 5 HOH 693 1393 115 HOH HOH A . 
EB 5 HOH 694 1394 463 HOH HOH A . 
EB 5 HOH 695 1395 429 HOH HOH A . 
EB 5 HOH 696 1396 545 HOH HOH A . 
EB 5 HOH 697 1397 32  HOH HOH A . 
EB 5 HOH 698 1398 210 HOH HOH A . 
EB 5 HOH 699 1399 790 HOH HOH A . 
EB 5 HOH 700 1400 130 HOH HOH A . 
EB 5 HOH 701 1401 122 HOH HOH A . 
EB 5 HOH 702 1402 37  HOH HOH A . 
EB 5 HOH 703 1403 494 HOH HOH A . 
EB 5 HOH 704 1404 232 HOH HOH A . 
EB 5 HOH 705 1405 190 HOH HOH A . 
EB 5 HOH 706 1406 33  HOH HOH A . 
EB 5 HOH 707 1407 31  HOH HOH A . 
EB 5 HOH 708 1408 603 HOH HOH A . 
EB 5 HOH 709 1409 346 HOH HOH A . 
EB 5 HOH 710 1410 413 HOH HOH A . 
EB 5 HOH 711 1411 639 HOH HOH A . 
EB 5 HOH 712 1412 22  HOH HOH A . 
EB 5 HOH 713 1413 600 HOH HOH A . 
EB 5 HOH 714 1414 344 HOH HOH A . 
EB 5 HOH 715 1415 574 HOH HOH A . 
EB 5 HOH 716 1416 590 HOH HOH A . 
EB 5 HOH 717 1417 359 HOH HOH A . 
EB 5 HOH 718 1418 306 HOH HOH A . 
EB 5 HOH 719 1419 360 HOH HOH A . 
EB 5 HOH 720 1420 176 HOH HOH A . 
EB 5 HOH 721 1421 554 HOH HOH A . 
EB 5 HOH 722 1422 373 HOH HOH A . 
EB 5 HOH 723 1423 352 HOH HOH A . 
EB 5 HOH 724 1424 535 HOH HOH A . 
EB 5 HOH 725 1425 213 HOH HOH A . 
EB 5 HOH 726 1426 27  HOH HOH A . 
EB 5 HOH 727 1427 114 HOH HOH A . 
EB 5 HOH 728 1428 155 HOH HOH A . 
EB 5 HOH 729 1429 70  HOH HOH A . 
EB 5 HOH 730 1430 505 HOH HOH A . 
EB 5 HOH 731 1431 118 HOH HOH A . 
EB 5 HOH 732 1432 64  HOH HOH A . 
EB 5 HOH 733 1433 561 HOH HOH A . 
EB 5 HOH 734 1434 100 HOH HOH A . 
EB 5 HOH 735 1435 63  HOH HOH A . 
EB 5 HOH 736 1436 594 HOH HOH A . 
EB 5 HOH 737 1437 409 HOH HOH A . 
EB 5 HOH 738 1438 271 HOH HOH A . 
EB 5 HOH 739 1439 16  HOH HOH A . 
EB 5 HOH 740 1440 45  HOH HOH A . 
EB 5 HOH 741 1441 398 HOH HOH A . 
EB 5 HOH 742 1442 726 HOH HOH A . 
EB 5 HOH 743 1443 547 HOH HOH A . 
EB 5 HOH 744 1444 501 HOH HOH A . 
EB 5 HOH 745 1445 426 HOH HOH A . 
EB 5 HOH 746 1446 106 HOH HOH A . 
EB 5 HOH 747 1447 559 HOH HOH A . 
EB 5 HOH 748 1448 619 HOH HOH A . 
EB 5 HOH 749 1449 126 HOH HOH A . 
EB 5 HOH 750 1450 105 HOH HOH A . 
EB 5 HOH 751 1451 340 HOH HOH A . 
EB 5 HOH 752 1452 405 HOH HOH A . 
EB 5 HOH 753 1453 460 HOH HOH A . 
EB 5 HOH 754 1454 454 HOH HOH A . 
EB 5 HOH 755 1455 701 HOH HOH A . 
EB 5 HOH 756 1456 121 HOH HOH A . 
EB 5 HOH 757 1457 453 HOH HOH A . 
EB 5 HOH 758 1458 431 HOH HOH A . 
EB 5 HOH 759 1459 127 HOH HOH A . 
EB 5 HOH 760 1460 586 HOH HOH A . 
EB 5 HOH 761 1461 520 HOH HOH A . 
EB 5 HOH 762 1462 354 HOH HOH A . 
EB 5 HOH 763 1463 438 HOH HOH A . 
EB 5 HOH 764 1464 544 HOH HOH A . 
EB 5 HOH 765 1465 456 HOH HOH A . 
EB 5 HOH 766 1466 92  HOH HOH A . 
EB 5 HOH 767 1467 125 HOH HOH A . 
EB 5 HOH 768 1468 129 HOH HOH A . 
EB 5 HOH 769 1469 680 HOH HOH A . 
EB 5 HOH 770 1470 791 HOH HOH A . 
EB 5 HOH 771 1471 737 HOH HOH A . 
EB 5 HOH 772 1472 357 HOH HOH A . 
EB 5 HOH 773 1473 767 HOH HOH A . 
EB 5 HOH 774 1474 36  HOH HOH A . 
EB 5 HOH 775 1475 622 HOH HOH A . 
EB 5 HOH 776 1476 636 HOH HOH A . 
EB 5 HOH 777 1477 90  HOH HOH A . 
EB 5 HOH 778 1478 778 HOH HOH A . 
EB 5 HOH 779 1479 58  HOH HOH A . 
EB 5 HOH 780 1480 137 HOH HOH A . 
EB 5 HOH 781 1481 540 HOH HOH A . 
EB 5 HOH 782 1482 566 HOH HOH A . 
EB 5 HOH 783 1483 84  HOH HOH A . 
EB 5 HOH 784 1484 514 HOH HOH A . 
EB 5 HOH 785 1485 76  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YUG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     97.580 
_cell.length_a_esd                 ? 
_cell.length_b                     97.580 
_cell.length_b_esd                 ? 
_cell.length_c                     196.966 
_cell.length_c_esd                 ? 
_cell.volume                       1875481.968 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YUG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            'P 4nw 2abw' 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YUG 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             ? 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          ? 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'di-ammonium phosphate, sodium acetate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     95 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 S 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-12-03 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.0000 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PHOTON FACTORY BEAMLINE BL-5A' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.0000 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL-5A 
_diffrn_source.pdbx_synchrotron_site       'Photon Factory' 
# 
_reflns.B_iso_Wilson_estimate                          20.32 
_reflns.entry_id                                       8YUG 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.71 
_reflns.d_resolution_low                               48.79 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     103180 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.95 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                26.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.83 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.1403 
_reflns.pdbx_Rpim_I_all                                0.0272 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1377 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.71 
_reflns_shell.d_res_low                                     1.771 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.30 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             10171 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               25.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               1.436 
_reflns_shell.pdbx_Rpim_I_all                               0.2803 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.893 
_reflns_shell.pdbx_CC_star                                  0.971 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.93 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.408 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               25.24 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YUG 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.71 
_refine.ls_d_res_low                             48.79 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     103133 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  101133 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.95 
_refine.ls_percent_reflns_R_free                 1.94 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1522 
_refine.ls_R_factor_R_free                       0.1726 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1518 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 16.9466 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1642 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.71 
_refine_hist.d_res_low                        48.79 
_refine_hist.number_atoms_solvent             785 
_refine_hist.number_atoms_total               4987 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3908 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         294 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0068  ? 4652 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8337  ? 6300 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0543  ? 623  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0061  ? 828  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 10.1356 ? 704  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.71 1.75  . . 140 7080 99.93  . . . . 0.2585 . . . . . . . . . . . 0.2944 
'X-RAY DIFFRACTION' 1.75 1.80  . . 141 7129 99.93  . . . . 0.2282 . . . . . . . . . . . 0.2319 
'X-RAY DIFFRACTION' 1.80 1.85  . . 141 7131 99.90  . . . . 0.1966 . . . . . . . . . . . 0.2302 
'X-RAY DIFFRACTION' 1.85 1.91  . . 142 7148 99.90  . . . . 0.1818 . . . . . . . . . . . 0.1854 
'X-RAY DIFFRACTION' 1.91 1.98  . . 141 7125 99.89  . . . . 0.1724 . . . . . . . . . . . 0.1996 
'X-RAY DIFFRACTION' 1.98 2.06  . . 141 7135 99.96  . . . . 0.1660 . . . . . . . . . . . 0.2026 
'X-RAY DIFFRACTION' 2.06 2.15  . . 141 7172 99.99  . . . . 0.1677 . . . . . . . . . . . 0.2086 
'X-RAY DIFFRACTION' 2.15 2.27  . . 143 7193 99.96  . . . . 0.1522 . . . . . . . . . . . 0.1826 
'X-RAY DIFFRACTION' 2.27 2.41  . . 142 7180 99.99  . . . . 0.1516 . . . . . . . . . . . 0.1684 
'X-RAY DIFFRACTION' 2.41 2.60  . . 143 7225 100.00 . . . . 0.1524 . . . . . . . . . . . 0.1860 
'X-RAY DIFFRACTION' 2.60 2.86  . . 144 7264 100.00 . . . . 0.1538 . . . . . . . . . . . 0.1569 
'X-RAY DIFFRACTION' 2.86 3.27  . . 143 7282 99.99  . . . . 0.1420 . . . . . . . . . . . 0.1654 
'X-RAY DIFFRACTION' 3.27 4.12  . . 145 7366 100.00 . . . . 0.1234 . . . . . . . . . . . 0.1416 
'X-RAY DIFFRACTION' 4.12 48.79 . . 153 7703 99.91  . . . . 0.1390 . . . . . . . . . . . 0.1545 
# 
_struct.entry_id                     8YUG 
_struct.title                        
'X-ray Crystal structure of glycoside hydrolase family 18 chitinase from Serratia marcescens hexahistigine-tagged SmChiB apo enzyme' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YUG 
_struct_keywords.text            'glycoside hydrolase family 18 GH18 chitinase apo enzyme hexahistigine-tag, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A  N N 1 ? 
B  N N 2 ? 
C  N N 2 ? 
D  N N 2 ? 
E  N N 3 ? 
F  N N 2 ? 
G  N N 2 ? 
H  N N 2 ? 
I  N N 3 ? 
J  N N 4 ? 
K  N N 2 ? 
L  N N 2 ? 
M  N N 2 ? 
N  N N 4 ? 
O  N N 2 ? 
P  N N 2 ? 
Q  N N 2 ? 
R  N N 4 ? 
S  N N 2 ? 
T  N N 2 ? 
U  N N 2 ? 
V  N N 2 ? 
W  N N 4 ? 
X  N N 2 ? 
Y  N N 2 ? 
Z  N N 2 ? 
AA N N 2 ? 
BA N N 2 ? 
CA N N 2 ? 
DA N N 2 ? 
EA N N 2 ? 
FA N N 2 ? 
GA N N 2 ? 
HA N N 2 ? 
IA N N 3 ? 
JA N N 3 ? 
KA N N 3 ? 
LA N N 3 ? 
MA N N 3 ? 
NA N N 3 ? 
OA N N 3 ? 
PA N N 3 ? 
QA N N 3 ? 
RA N N 3 ? 
SA N N 3 ? 
TA N N 3 ? 
UA N N 3 ? 
VA N N 2 ? 
WA N N 2 ? 
XA N N 2 ? 
YA N N 2 ? 
ZA N N 2 ? 
AB N N 2 ? 
BB N N 2 ? 
CB N N 2 ? 
DB N N 3 ? 
EB N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CHIB_SERMA 
_struct_ref.pdbx_db_accession          P11797 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;STRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFLDINSNLECAWDPATNDAKARDVVNRLTAL
KAHNPSLRIMFSIGGWYYSNDLGVSHANYVNAVKTPAARTKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVDGFIAALQEI
RTLLNQQTIADGRQALPYQLTIAGAGGAFFLSRYYSKLAQIVAPLDYINLMTYDLAGPWEKITNHQAALFGDAAGPTFYN
ALREANLGWSWEELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYGRAFKGVSGGNGGQYSSHSTPGEDPYPNA
DYWLVGCDECVRDKDPRIASYRQLEQMLQGNYGYQRLWNDKTKTPYLYHAQNGLFVTYDDAESFKYKAKYIKQQQLGGVM
FWHLGQDNRNGDLLAALDRYFNAADYDDSQLDMGTGLRYTGVGPGNLPIMTAPAYVPGTTYAQGALVSYQGYVWQTKWGY
ITSAPGSDSAWLKVGRLA
;
_struct_ref.pdbx_align_begin           2 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8YUG 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 500 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P11797 
_struct_ref_seq.db_align_beg                  2 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  499 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       2 
_struct_ref_seq.pdbx_auth_seq_align_end       499 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YUG MET A 1   ? UNP P11797 ? ? 'initiating methionine' 0   1  
1 8YUG ASP A 2   ? UNP P11797 ? ? 'expression tag'        1   2  
1 8YUG ALA A 501 ? UNP P11797 ? ? 'expression tag'        500 3  
1 8YUG ALA A 502 ? UNP P11797 ? ? 'expression tag'        501 4  
1 8YUG ALA A 503 ? UNP P11797 ? ? 'expression tag'        502 5  
1 8YUG LEU A 504 ? UNP P11797 ? ? 'expression tag'        503 6  
1 8YUG GLU A 505 ? UNP P11797 ? ? 'expression tag'        504 7  
1 8YUG HIS A 506 ? UNP P11797 ? ? 'expression tag'        505 8  
1 8YUG HIS A 507 ? UNP P11797 ? ? 'expression tag'        506 9  
1 8YUG HIS A 508 ? UNP P11797 ? ? 'expression tag'        507 10 
1 8YUG HIS A 509 ? UNP P11797 ? ? 'expression tag'        508 11 
1 8YUG HIS A 510 ? UNP P11797 ? ? 'expression tag'        509 12 
1 8YUG HIS A 511 ? UNP P11797 ? ? 'expression tag'        510 13 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      
;A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,AA,BA,CA,DA,EA,FA,GA,HA,IA,JA,KA,LA,MA,NA,OA,PA,QA,RA,SA,TA,UA,VA,WA,XA,YA,ZA,AB,BB,CB,DB,EB
;
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 15  ? ASN A 21  ? PRO A 14  ASN A 20  1 ? 7  
HELX_P HELX_P2  AA2 PRO A 33  ? ILE A 37  ? PRO A 32  ILE A 36  5 ? 5  
HELX_P HELX_P3  AA3 THR A 38  ? LEU A 45  ? THR A 37  LEU A 44  1 ? 8  
HELX_P HELX_P4  AA4 ASN A 68  ? LEU A 82  ? ASN A 67  LEU A 81  1 ? 15 
HELX_P HELX_P5  AA5 LYS A 83  ? ASN A 86  ? LYS A 82  ASN A 85  5 ? 4  
HELX_P HELX_P6  AA6 GLY A 97  ? ASN A 102 ? GLY A 96  ASN A 101 1 ? 6  
HELX_P HELX_P7  AA7 SER A 107 ? VAL A 115 ? SER A 106 VAL A 114 1 ? 9  
HELX_P HELX_P8  AA8 THR A 117 ? GLY A 136 ? THR A 116 GLY A 135 1 ? 20 
HELX_P HELX_P9  AA9 GLN A 148 ? ALA A 150 ? GLN A 147 ALA A 149 5 ? 3  
HELX_P HELX_P10 AB1 GLU A 151 ? ASP A 173 ? GLU A 150 ASP A 172 1 ? 23 
HELX_P HELX_P11 AB2 GLY A 189 ? SER A 194 ? GLY A 188 SER A 193 1 ? 6  
HELX_P HELX_P12 AB3 ARG A 195 ? SER A 198 ? ARG A 194 SER A 197 5 ? 4  
HELX_P HELX_P13 AB4 LYS A 199 ? ALA A 205 ? LYS A 198 ALA A 204 1 ? 7  
HELX_P HELX_P14 AB5 ASN A 242 ? ALA A 247 ? ASN A 241 ALA A 246 5 ? 6  
HELX_P HELX_P15 AB6 SER A 252 ? PHE A 260 ? SER A 251 PHE A 259 1 ? 9  
HELX_P HELX_P16 AB7 THR A 267 ? MET A 277 ? THR A 266 MET A 276 1 ? 11 
HELX_P HELX_P17 AB8 PRO A 282 ? ALA A 284 ? PRO A 281 ALA A 283 5 ? 3  
HELX_P HELX_P18 AB9 CYS A 329 ? ASP A 335 ? CYS A 328 ASP A 334 1 ? 7  
HELX_P HELX_P19 AC1 TYR A 343 ? GLY A 352 ? TYR A 342 GLY A 351 1 ? 10 
HELX_P HELX_P20 AC2 ASP A 382 ? GLN A 396 ? ASP A 381 GLN A 395 1 ? 15 
HELX_P HELX_P21 AC3 HIS A 405 ? ASP A 409 ? HIS A 404 ASP A 408 5 ? 5  
HELX_P HELX_P22 AC4 GLY A 413 ? ALA A 425 ? GLY A 412 ALA A 424 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 61  SG B ? ? 1_555 A CYS 128 SG B ? A CYS 60  A CYS 127 1_555 ? ? ? ? ? ? ? 2.035 ? ? 
disulf2 disulf ? ? A CYS 329 SG ? ? ? 1_555 A CYS 332 SG ? ? A CYS 328 A CYS 331 1_555 ? ? ? ? ? ? ? 2.060 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 61  B CYS A 128 B CYS A 60  ? 1_555 CYS A 127 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 329 ? CYS A 332 ? CYS A 328 ? 1_555 CYS A 331 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 SER 51  A . ? SER 50  A PHE 52  A ? PHE 51  A 1 -3.18  
2 GLU 145 A . ? GLU 144 A TYR 146 A ? TYR 145 A 1 5.41   
3 SER 262 A . ? SER 261 A PRO 263 A ? PRO 262 A 1 -0.66  
4 ASP 317 A . ? ASP 316 A PRO 318 A ? PRO 317 A 1 -2.42  
5 ASP 317 A . ? ASP 316 A PRO 318 A ? PRO 317 A 1 5.95   
6 TRP 404 A . ? TRP 403 A HIS 405 A ? HIS 404 A 1 -13.74 
7 GLY 481 A . ? GLY 480 A TYR 482 A ? TYR 481 A 1 -2.05  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 5  ? 
AA3 ? 3  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? anti-parallel 
AA1 2 3  ? parallel      
AA1 3 4  ? parallel      
AA1 4 5  ? parallel      
AA1 5 6  ? parallel      
AA1 6 7  ? parallel      
AA1 7 8  ? parallel      
AA1 8 9  ? parallel      
AA1 9 10 ? parallel      
AA2 1 2  ? anti-parallel 
AA2 2 3  ? anti-parallel 
AA2 3 4  ? anti-parallel 
AA2 4 5  ? anti-parallel 
AA3 1 2  ? anti-parallel 
AA3 2 3  ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  CYS A 61  ? ALA A 62  ? CYS A 60  ALA A 61  
AA1 2  HIS A 47  ? ILE A 55  ? HIS A 46  ILE A 54  
AA1 3  ARG A 90  ? GLY A 96  ? ARG A 89  GLY A 95  
AA1 4  GLY A 139 ? ASP A 143 ? GLY A 138 ASP A 142 
AA1 5  GLN A 181 ? ALA A 187 ? GLN A 180 ALA A 186 
AA1 6  TYR A 209 ? MET A 213 ? TYR A 208 MET A 212 
AA1 7  ILE A 286 ? PRO A 291 ? ILE A 285 PRO A 290 
AA1 8  GLY A 400 ? TRP A 404 ? GLY A 399 TRP A 403 
AA1 9  ALA A 7   ? PHE A 13  ? ALA A 6   PHE A 12  
AA1 10 HIS A 47  ? ILE A 55  ? HIS A 46  ILE A 54  
AA2 1  ILE A 340 ? SER A 342 ? ILE A 339 SER A 341 
AA2 2  TYR A 293 ? PHE A 297 ? TYR A 292 PHE A 296 
AA2 3  LEU A 376 ? THR A 379 ? LEU A 375 THR A 378 
AA2 4  THR A 366 ? HIS A 371 ? THR A 365 HIS A 370 
AA2 5  TYR A 356 ? ASN A 361 ? TYR A 355 ASN A 360 
AA3 1  LEU A 468 ? TYR A 471 ? LEU A 467 TYR A 470 
AA3 2  TYR A 474 ? THR A 478 ? TYR A 473 THR A 477 
AA3 3  TRP A 493 ? ARG A 498 ? TRP A 492 ARG A 497 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  O ALA A 62  ? O ALA A 61  N ASP A 54  ? N ASP A 53  
AA1 2 3  N LEU A 53  ? N LEU A 52  O SER A 94  ? O SER A 93  
AA1 3 4  N ILE A 95  ? N ILE A 94  O ASP A 143 ? O ASP A 142 
AA1 4 5  N VAL A 140 ? N VAL A 139 O GLN A 181 ? O GLN A 180 
AA1 5 6  N ILE A 184 ? N ILE A 183 O ASN A 211 ? O ASN A 210 
AA1 6 7  N LEU A 212 ? N LEU A 211 O VAL A 287 ? O VAL A 286 
AA1 7 8  N MET A 288 ? N MET A 287 O MET A 402 ? O MET A 401 
AA1 8 9  O VAL A 401 ? O VAL A 400 N ILE A 9   ? N ILE A 8   
AA1 9 10 N GLY A 10  ? N GLY A 9   O HIS A 47  ? O HIS A 46  
AA2 1 2  O ALA A 341 ? O ALA A 340 N GLY A 294 ? N GLY A 293 
AA2 2 3  N PHE A 297 ? N PHE A 296 O PHE A 377 ? O PHE A 376 
AA2 3 4  O LEU A 376 ? O LEU A 375 N HIS A 371 ? N HIS A 370 
AA2 4 5  O TYR A 368 ? O TYR A 367 N LEU A 359 ? N LEU A 358 
AA3 1 2  N VAL A 469 ? N VAL A 468 O TRP A 476 ? O TRP A 475 
AA3 2 3  N GLN A 477 ? N GLN A 476 O LEU A 494 ? O LEU A 493 
# 
_pdbx_entry_details.entry_id                   8YUG 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 142 ? ? -119.40 61.13  
2 1 ALA A 148 ? A -23.75  -54.63 
3 1 ALA A 228 ? ? -152.35 49.31  
4 1 ASN A 303 ? ? -141.69 42.63  
5 1 ASP A 336 ? ? -160.97 112.81 
6 1 ASN A 447 ? ? -140.26 42.77  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 738 ? EB HOH . 
2 1 A HOH 919 ? EB HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+3/4  
3 y+1/2,-x+1/2,z+1/4  
4 x+1/2,-y+1/2,-z+1/4 
5 -x+1/2,y+1/2,-z+3/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1484 ? 5.89 . 
2 1 O ? A HOH 1485 ? 6.99 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 0   ? A MET 1   
2  1 Y 1 A ASP 1   ? A ASP 2   
3  1 Y 1 A ALA 499 ? A ALA 500 
4  1 Y 1 A ALA 500 ? A ALA 501 
5  1 Y 1 A ALA 501 ? A ALA 502 
6  1 Y 1 A ALA 502 ? A ALA 503 
7  1 Y 1 A LEU 503 ? A LEU 504 
8  1 Y 1 A GLU 504 ? A GLU 505 
9  1 Y 1 A HIS 505 ? A HIS 506 
10 1 Y 1 A HIS 506 ? A HIS 507 
11 1 Y 1 A HIS 507 ? A HIS 508 
12 1 Y 1 A HIS 508 ? A HIS 509 
13 1 Y 1 A HIS 509 ? A HIS 510 
14 1 Y 1 A HIS 510 ? A HIS 511 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACT C    C N N 1   
ACT O    O N N 2   
ACT OXT  O N N 3   
ACT CH3  C N N 4   
ACT H1   H N N 5   
ACT H2   H N N 6   
ACT H3   H N N 7   
ALA N    N N N 8   
ALA CA   C N S 9   
ALA C    C N N 10  
ALA O    O N N 11  
ALA CB   C N N 12  
ALA OXT  O N N 13  
ALA H    H N N 14  
ALA H2   H N N 15  
ALA HA   H N N 16  
ALA HB1  H N N 17  
ALA HB2  H N N 18  
ALA HB3  H N N 19  
ALA HXT  H N N 20  
ARG N    N N N 21  
ARG CA   C N S 22  
ARG C    C N N 23  
ARG O    O N N 24  
ARG CB   C N N 25  
ARG CG   C N N 26  
ARG CD   C N N 27  
ARG NE   N N N 28  
ARG CZ   C N N 29  
ARG NH1  N N N 30  
ARG NH2  N N N 31  
ARG OXT  O N N 32  
ARG H    H N N 33  
ARG H2   H N N 34  
ARG HA   H N N 35  
ARG HB2  H N N 36  
ARG HB3  H N N 37  
ARG HG2  H N N 38  
ARG HG3  H N N 39  
ARG HD2  H N N 40  
ARG HD3  H N N 41  
ARG HE   H N N 42  
ARG HH11 H N N 43  
ARG HH12 H N N 44  
ARG HH21 H N N 45  
ARG HH22 H N N 46  
ARG HXT  H N N 47  
ASN N    N N N 48  
ASN CA   C N S 49  
ASN C    C N N 50  
ASN O    O N N 51  
ASN CB   C N N 52  
ASN CG   C N N 53  
ASN OD1  O N N 54  
ASN ND2  N N N 55  
ASN OXT  O N N 56  
ASN H    H N N 57  
ASN H2   H N N 58  
ASN HA   H N N 59  
ASN HB2  H N N 60  
ASN HB3  H N N 61  
ASN HD21 H N N 62  
ASN HD22 H N N 63  
ASN HXT  H N N 64  
ASP N    N N N 65  
ASP CA   C N S 66  
ASP C    C N N 67  
ASP O    O N N 68  
ASP CB   C N N 69  
ASP CG   C N N 70  
ASP OD1  O N N 71  
ASP OD2  O N N 72  
ASP OXT  O N N 73  
ASP H    H N N 74  
ASP H2   H N N 75  
ASP HA   H N N 76  
ASP HB2  H N N 77  
ASP HB3  H N N 78  
ASP HD2  H N N 79  
ASP HXT  H N N 80  
CYS N    N N N 81  
CYS CA   C N R 82  
CYS C    C N N 83  
CYS O    O N N 84  
CYS CB   C N N 85  
CYS SG   S N N 86  
CYS OXT  O N N 87  
CYS H    H N N 88  
CYS H2   H N N 89  
CYS HA   H N N 90  
CYS HB2  H N N 91  
CYS HB3  H N N 92  
CYS HG   H N N 93  
CYS HXT  H N N 94  
GLN N    N N N 95  
GLN CA   C N S 96  
GLN C    C N N 97  
GLN O    O N N 98  
GLN CB   C N N 99  
GLN CG   C N N 100 
GLN CD   C N N 101 
GLN OE1  O N N 102 
GLN NE2  N N N 103 
GLN OXT  O N N 104 
GLN H    H N N 105 
GLN H2   H N N 106 
GLN HA   H N N 107 
GLN HB2  H N N 108 
GLN HB3  H N N 109 
GLN HG2  H N N 110 
GLN HG3  H N N 111 
GLN HE21 H N N 112 
GLN HE22 H N N 113 
GLN HXT  H N N 114 
GLU N    N N N 115 
GLU CA   C N S 116 
GLU C    C N N 117 
GLU O    O N N 118 
GLU CB   C N N 119 
GLU CG   C N N 120 
GLU CD   C N N 121 
GLU OE1  O N N 122 
GLU OE2  O N N 123 
GLU OXT  O N N 124 
GLU H    H N N 125 
GLU H2   H N N 126 
GLU HA   H N N 127 
GLU HB2  H N N 128 
GLU HB3  H N N 129 
GLU HG2  H N N 130 
GLU HG3  H N N 131 
GLU HE2  H N N 132 
GLU HXT  H N N 133 
GLY N    N N N 134 
GLY CA   C N N 135 
GLY C    C N N 136 
GLY O    O N N 137 
GLY OXT  O N N 138 
GLY H    H N N 139 
GLY H2   H N N 140 
GLY HA2  H N N 141 
GLY HA3  H N N 142 
GLY HXT  H N N 143 
GOL C1   C N N 144 
GOL O1   O N N 145 
GOL C2   C N N 146 
GOL O2   O N N 147 
GOL C3   C N N 148 
GOL O3   O N N 149 
GOL H11  H N N 150 
GOL H12  H N N 151 
GOL HO1  H N N 152 
GOL H2   H N N 153 
GOL HO2  H N N 154 
GOL H31  H N N 155 
GOL H32  H N N 156 
GOL HO3  H N N 157 
HIS N    N N N 158 
HIS CA   C N S 159 
HIS C    C N N 160 
HIS O    O N N 161 
HIS CB   C N N 162 
HIS CG   C Y N 163 
HIS ND1  N Y N 164 
HIS CD2  C Y N 165 
HIS CE1  C Y N 166 
HIS NE2  N Y N 167 
HIS OXT  O N N 168 
HIS H    H N N 169 
HIS H2   H N N 170 
HIS HA   H N N 171 
HIS HB2  H N N 172 
HIS HB3  H N N 173 
HIS HD1  H N N 174 
HIS HD2  H N N 175 
HIS HE1  H N N 176 
HIS HE2  H N N 177 
HIS HXT  H N N 178 
HOH O    O N N 179 
HOH H1   H N N 180 
HOH H2   H N N 181 
ILE N    N N N 182 
ILE CA   C N S 183 
ILE C    C N N 184 
ILE O    O N N 185 
ILE CB   C N S 186 
ILE CG1  C N N 187 
ILE CG2  C N N 188 
ILE CD1  C N N 189 
ILE OXT  O N N 190 
ILE H    H N N 191 
ILE H2   H N N 192 
ILE HA   H N N 193 
ILE HB   H N N 194 
ILE HG12 H N N 195 
ILE HG13 H N N 196 
ILE HG21 H N N 197 
ILE HG22 H N N 198 
ILE HG23 H N N 199 
ILE HD11 H N N 200 
ILE HD12 H N N 201 
ILE HD13 H N N 202 
ILE HXT  H N N 203 
LEU N    N N N 204 
LEU CA   C N S 205 
LEU C    C N N 206 
LEU O    O N N 207 
LEU CB   C N N 208 
LEU CG   C N N 209 
LEU CD1  C N N 210 
LEU CD2  C N N 211 
LEU OXT  O N N 212 
LEU H    H N N 213 
LEU H2   H N N 214 
LEU HA   H N N 215 
LEU HB2  H N N 216 
LEU HB3  H N N 217 
LEU HG   H N N 218 
LEU HD11 H N N 219 
LEU HD12 H N N 220 
LEU HD13 H N N 221 
LEU HD21 H N N 222 
LEU HD22 H N N 223 
LEU HD23 H N N 224 
LEU HXT  H N N 225 
LYS N    N N N 226 
LYS CA   C N S 227 
LYS C    C N N 228 
LYS O    O N N 229 
LYS CB   C N N 230 
LYS CG   C N N 231 
LYS CD   C N N 232 
LYS CE   C N N 233 
LYS NZ   N N N 234 
LYS OXT  O N N 235 
LYS H    H N N 236 
LYS H2   H N N 237 
LYS HA   H N N 238 
LYS HB2  H N N 239 
LYS HB3  H N N 240 
LYS HG2  H N N 241 
LYS HG3  H N N 242 
LYS HD2  H N N 243 
LYS HD3  H N N 244 
LYS HE2  H N N 245 
LYS HE3  H N N 246 
LYS HZ1  H N N 247 
LYS HZ2  H N N 248 
LYS HZ3  H N N 249 
LYS HXT  H N N 250 
MET N    N N N 251 
MET CA   C N S 252 
MET C    C N N 253 
MET O    O N N 254 
MET CB   C N N 255 
MET CG   C N N 256 
MET SD   S N N 257 
MET CE   C N N 258 
MET OXT  O N N 259 
MET H    H N N 260 
MET H2   H N N 261 
MET HA   H N N 262 
MET HB2  H N N 263 
MET HB3  H N N 264 
MET HG2  H N N 265 
MET HG3  H N N 266 
MET HE1  H N N 267 
MET HE2  H N N 268 
MET HE3  H N N 269 
MET HXT  H N N 270 
PHE N    N N N 271 
PHE CA   C N S 272 
PHE C    C N N 273 
PHE O    O N N 274 
PHE CB   C N N 275 
PHE CG   C Y N 276 
PHE CD1  C Y N 277 
PHE CD2  C Y N 278 
PHE CE1  C Y N 279 
PHE CE2  C Y N 280 
PHE CZ   C Y N 281 
PHE OXT  O N N 282 
PHE H    H N N 283 
PHE H2   H N N 284 
PHE HA   H N N 285 
PHE HB2  H N N 286 
PHE HB3  H N N 287 
PHE HD1  H N N 288 
PHE HD2  H N N 289 
PHE HE1  H N N 290 
PHE HE2  H N N 291 
PHE HZ   H N N 292 
PHE HXT  H N N 293 
PO4 P    P N N 294 
PO4 O1   O N N 295 
PO4 O2   O N N 296 
PO4 O3   O N N 297 
PO4 O4   O N N 298 
PRO N    N N N 299 
PRO CA   C N S 300 
PRO C    C N N 301 
PRO O    O N N 302 
PRO CB   C N N 303 
PRO CG   C N N 304 
PRO CD   C N N 305 
PRO OXT  O N N 306 
PRO H    H N N 307 
PRO HA   H N N 308 
PRO HB2  H N N 309 
PRO HB3  H N N 310 
PRO HG2  H N N 311 
PRO HG3  H N N 312 
PRO HD2  H N N 313 
PRO HD3  H N N 314 
PRO HXT  H N N 315 
SER N    N N N 316 
SER CA   C N S 317 
SER C    C N N 318 
SER O    O N N 319 
SER CB   C N N 320 
SER OG   O N N 321 
SER OXT  O N N 322 
SER H    H N N 323 
SER H2   H N N 324 
SER HA   H N N 325 
SER HB2  H N N 326 
SER HB3  H N N 327 
SER HG   H N N 328 
SER HXT  H N N 329 
THR N    N N N 330 
THR CA   C N S 331 
THR C    C N N 332 
THR O    O N N 333 
THR CB   C N R 334 
THR OG1  O N N 335 
THR CG2  C N N 336 
THR OXT  O N N 337 
THR H    H N N 338 
THR H2   H N N 339 
THR HA   H N N 340 
THR HB   H N N 341 
THR HG1  H N N 342 
THR HG21 H N N 343 
THR HG22 H N N 344 
THR HG23 H N N 345 
THR HXT  H N N 346 
TRP N    N N N 347 
TRP CA   C N S 348 
TRP C    C N N 349 
TRP O    O N N 350 
TRP CB   C N N 351 
TRP CG   C Y N 352 
TRP CD1  C Y N 353 
TRP CD2  C Y N 354 
TRP NE1  N Y N 355 
TRP CE2  C Y N 356 
TRP CE3  C Y N 357 
TRP CZ2  C Y N 358 
TRP CZ3  C Y N 359 
TRP CH2  C Y N 360 
TRP OXT  O N N 361 
TRP H    H N N 362 
TRP H2   H N N 363 
TRP HA   H N N 364 
TRP HB2  H N N 365 
TRP HB3  H N N 366 
TRP HD1  H N N 367 
TRP HE1  H N N 368 
TRP HE3  H N N 369 
TRP HZ2  H N N 370 
TRP HZ3  H N N 371 
TRP HH2  H N N 372 
TRP HXT  H N N 373 
TYR N    N N N 374 
TYR CA   C N S 375 
TYR C    C N N 376 
TYR O    O N N 377 
TYR CB   C N N 378 
TYR CG   C Y N 379 
TYR CD1  C Y N 380 
TYR CD2  C Y N 381 
TYR CE1  C Y N 382 
TYR CE2  C Y N 383 
TYR CZ   C Y N 384 
TYR OH   O N N 385 
TYR OXT  O N N 386 
TYR H    H N N 387 
TYR H2   H N N 388 
TYR HA   H N N 389 
TYR HB2  H N N 390 
TYR HB3  H N N 391 
TYR HD1  H N N 392 
TYR HD2  H N N 393 
TYR HE1  H N N 394 
TYR HE2  H N N 395 
TYR HH   H N N 396 
TYR HXT  H N N 397 
VAL N    N N N 398 
VAL CA   C N S 399 
VAL C    C N N 400 
VAL O    O N N 401 
VAL CB   C N N 402 
VAL CG1  C N N 403 
VAL CG2  C N N 404 
VAL OXT  O N N 405 
VAL H    H N N 406 
VAL H2   H N N 407 
VAL HA   H N N 408 
VAL HB   H N N 409 
VAL HG11 H N N 410 
VAL HG12 H N N 411 
VAL HG13 H N N 412 
VAL HG21 H N N 413 
VAL HG22 H N N 414 
VAL HG23 H N N 415 
VAL HXT  H N N 416 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACT C   O    doub N N 1   
ACT C   OXT  sing N N 2   
ACT C   CH3  sing N N 3   
ACT CH3 H1   sing N N 4   
ACT CH3 H2   sing N N 5   
ACT CH3 H3   sing N N 6   
ALA N   CA   sing N N 7   
ALA N   H    sing N N 8   
ALA N   H2   sing N N 9   
ALA CA  C    sing N N 10  
ALA CA  CB   sing N N 11  
ALA CA  HA   sing N N 12  
ALA C   O    doub N N 13  
ALA C   OXT  sing N N 14  
ALA CB  HB1  sing N N 15  
ALA CB  HB2  sing N N 16  
ALA CB  HB3  sing N N 17  
ALA OXT HXT  sing N N 18  
ARG N   CA   sing N N 19  
ARG N   H    sing N N 20  
ARG N   H2   sing N N 21  
ARG CA  C    sing N N 22  
ARG CA  CB   sing N N 23  
ARG CA  HA   sing N N 24  
ARG C   O    doub N N 25  
ARG C   OXT  sing N N 26  
ARG CB  CG   sing N N 27  
ARG CB  HB2  sing N N 28  
ARG CB  HB3  sing N N 29  
ARG CG  CD   sing N N 30  
ARG CG  HG2  sing N N 31  
ARG CG  HG3  sing N N 32  
ARG CD  NE   sing N N 33  
ARG CD  HD2  sing N N 34  
ARG CD  HD3  sing N N 35  
ARG NE  CZ   sing N N 36  
ARG NE  HE   sing N N 37  
ARG CZ  NH1  sing N N 38  
ARG CZ  NH2  doub N N 39  
ARG NH1 HH11 sing N N 40  
ARG NH1 HH12 sing N N 41  
ARG NH2 HH21 sing N N 42  
ARG NH2 HH22 sing N N 43  
ARG OXT HXT  sing N N 44  
ASN N   CA   sing N N 45  
ASN N   H    sing N N 46  
ASN N   H2   sing N N 47  
ASN CA  C    sing N N 48  
ASN CA  CB   sing N N 49  
ASN CA  HA   sing N N 50  
ASN C   O    doub N N 51  
ASN C   OXT  sing N N 52  
ASN CB  CG   sing N N 53  
ASN CB  HB2  sing N N 54  
ASN CB  HB3  sing N N 55  
ASN CG  OD1  doub N N 56  
ASN CG  ND2  sing N N 57  
ASN ND2 HD21 sing N N 58  
ASN ND2 HD22 sing N N 59  
ASN OXT HXT  sing N N 60  
ASP N   CA   sing N N 61  
ASP N   H    sing N N 62  
ASP N   H2   sing N N 63  
ASP CA  C    sing N N 64  
ASP CA  CB   sing N N 65  
ASP CA  HA   sing N N 66  
ASP C   O    doub N N 67  
ASP C   OXT  sing N N 68  
ASP CB  CG   sing N N 69  
ASP CB  HB2  sing N N 70  
ASP CB  HB3  sing N N 71  
ASP CG  OD1  doub N N 72  
ASP CG  OD2  sing N N 73  
ASP OD2 HD2  sing N N 74  
ASP OXT HXT  sing N N 75  
CYS N   CA   sing N N 76  
CYS N   H    sing N N 77  
CYS N   H2   sing N N 78  
CYS CA  C    sing N N 79  
CYS CA  CB   sing N N 80  
CYS CA  HA   sing N N 81  
CYS C   O    doub N N 82  
CYS C   OXT  sing N N 83  
CYS CB  SG   sing N N 84  
CYS CB  HB2  sing N N 85  
CYS CB  HB3  sing N N 86  
CYS SG  HG   sing N N 87  
CYS OXT HXT  sing N N 88  
GLN N   CA   sing N N 89  
GLN N   H    sing N N 90  
GLN N   H2   sing N N 91  
GLN CA  C    sing N N 92  
GLN CA  CB   sing N N 93  
GLN CA  HA   sing N N 94  
GLN C   O    doub N N 95  
GLN C   OXT  sing N N 96  
GLN CB  CG   sing N N 97  
GLN CB  HB2  sing N N 98  
GLN CB  HB3  sing N N 99  
GLN CG  CD   sing N N 100 
GLN CG  HG2  sing N N 101 
GLN CG  HG3  sing N N 102 
GLN CD  OE1  doub N N 103 
GLN CD  NE2  sing N N 104 
GLN NE2 HE21 sing N N 105 
GLN NE2 HE22 sing N N 106 
GLN OXT HXT  sing N N 107 
GLU N   CA   sing N N 108 
GLU N   H    sing N N 109 
GLU N   H2   sing N N 110 
GLU CA  C    sing N N 111 
GLU CA  CB   sing N N 112 
GLU CA  HA   sing N N 113 
GLU C   O    doub N N 114 
GLU C   OXT  sing N N 115 
GLU CB  CG   sing N N 116 
GLU CB  HB2  sing N N 117 
GLU CB  HB3  sing N N 118 
GLU CG  CD   sing N N 119 
GLU CG  HG2  sing N N 120 
GLU CG  HG3  sing N N 121 
GLU CD  OE1  doub N N 122 
GLU CD  OE2  sing N N 123 
GLU OE2 HE2  sing N N 124 
GLU OXT HXT  sing N N 125 
GLY N   CA   sing N N 126 
GLY N   H    sing N N 127 
GLY N   H2   sing N N 128 
GLY CA  C    sing N N 129 
GLY CA  HA2  sing N N 130 
GLY CA  HA3  sing N N 131 
GLY C   O    doub N N 132 
GLY C   OXT  sing N N 133 
GLY OXT HXT  sing N N 134 
GOL C1  O1   sing N N 135 
GOL C1  C2   sing N N 136 
GOL C1  H11  sing N N 137 
GOL C1  H12  sing N N 138 
GOL O1  HO1  sing N N 139 
GOL C2  O2   sing N N 140 
GOL C2  C3   sing N N 141 
GOL C2  H2   sing N N 142 
GOL O2  HO2  sing N N 143 
GOL C3  O3   sing N N 144 
GOL C3  H31  sing N N 145 
GOL C3  H32  sing N N 146 
GOL O3  HO3  sing N N 147 
HIS N   CA   sing N N 148 
HIS N   H    sing N N 149 
HIS N   H2   sing N N 150 
HIS CA  C    sing N N 151 
HIS CA  CB   sing N N 152 
HIS CA  HA   sing N N 153 
HIS C   O    doub N N 154 
HIS C   OXT  sing N N 155 
HIS CB  CG   sing N N 156 
HIS CB  HB2  sing N N 157 
HIS CB  HB3  sing N N 158 
HIS CG  ND1  sing Y N 159 
HIS CG  CD2  doub Y N 160 
HIS ND1 CE1  doub Y N 161 
HIS ND1 HD1  sing N N 162 
HIS CD2 NE2  sing Y N 163 
HIS CD2 HD2  sing N N 164 
HIS CE1 NE2  sing Y N 165 
HIS CE1 HE1  sing N N 166 
HIS NE2 HE2  sing N N 167 
HIS OXT HXT  sing N N 168 
HOH O   H1   sing N N 169 
HOH O   H2   sing N N 170 
ILE N   CA   sing N N 171 
ILE N   H    sing N N 172 
ILE N   H2   sing N N 173 
ILE CA  C    sing N N 174 
ILE CA  CB   sing N N 175 
ILE CA  HA   sing N N 176 
ILE C   O    doub N N 177 
ILE C   OXT  sing N N 178 
ILE CB  CG1  sing N N 179 
ILE CB  CG2  sing N N 180 
ILE CB  HB   sing N N 181 
ILE CG1 CD1  sing N N 182 
ILE CG1 HG12 sing N N 183 
ILE CG1 HG13 sing N N 184 
ILE CG2 HG21 sing N N 185 
ILE CG2 HG22 sing N N 186 
ILE CG2 HG23 sing N N 187 
ILE CD1 HD11 sing N N 188 
ILE CD1 HD12 sing N N 189 
ILE CD1 HD13 sing N N 190 
ILE OXT HXT  sing N N 191 
LEU N   CA   sing N N 192 
LEU N   H    sing N N 193 
LEU N   H2   sing N N 194 
LEU CA  C    sing N N 195 
LEU CA  CB   sing N N 196 
LEU CA  HA   sing N N 197 
LEU C   O    doub N N 198 
LEU C   OXT  sing N N 199 
LEU CB  CG   sing N N 200 
LEU CB  HB2  sing N N 201 
LEU CB  HB3  sing N N 202 
LEU CG  CD1  sing N N 203 
LEU CG  CD2  sing N N 204 
LEU CG  HG   sing N N 205 
LEU CD1 HD11 sing N N 206 
LEU CD1 HD12 sing N N 207 
LEU CD1 HD13 sing N N 208 
LEU CD2 HD21 sing N N 209 
LEU CD2 HD22 sing N N 210 
LEU CD2 HD23 sing N N 211 
LEU OXT HXT  sing N N 212 
LYS N   CA   sing N N 213 
LYS N   H    sing N N 214 
LYS N   H2   sing N N 215 
LYS CA  C    sing N N 216 
LYS CA  CB   sing N N 217 
LYS CA  HA   sing N N 218 
LYS C   O    doub N N 219 
LYS C   OXT  sing N N 220 
LYS CB  CG   sing N N 221 
LYS CB  HB2  sing N N 222 
LYS CB  HB3  sing N N 223 
LYS CG  CD   sing N N 224 
LYS CG  HG2  sing N N 225 
LYS CG  HG3  sing N N 226 
LYS CD  CE   sing N N 227 
LYS CD  HD2  sing N N 228 
LYS CD  HD3  sing N N 229 
LYS CE  NZ   sing N N 230 
LYS CE  HE2  sing N N 231 
LYS CE  HE3  sing N N 232 
LYS NZ  HZ1  sing N N 233 
LYS NZ  HZ2  sing N N 234 
LYS NZ  HZ3  sing N N 235 
LYS OXT HXT  sing N N 236 
MET N   CA   sing N N 237 
MET N   H    sing N N 238 
MET N   H2   sing N N 239 
MET CA  C    sing N N 240 
MET CA  CB   sing N N 241 
MET CA  HA   sing N N 242 
MET C   O    doub N N 243 
MET C   OXT  sing N N 244 
MET CB  CG   sing N N 245 
MET CB  HB2  sing N N 246 
MET CB  HB3  sing N N 247 
MET CG  SD   sing N N 248 
MET CG  HG2  sing N N 249 
MET CG  HG3  sing N N 250 
MET SD  CE   sing N N 251 
MET CE  HE1  sing N N 252 
MET CE  HE2  sing N N 253 
MET CE  HE3  sing N N 254 
MET OXT HXT  sing N N 255 
PHE N   CA   sing N N 256 
PHE N   H    sing N N 257 
PHE N   H2   sing N N 258 
PHE CA  C    sing N N 259 
PHE CA  CB   sing N N 260 
PHE CA  HA   sing N N 261 
PHE C   O    doub N N 262 
PHE C   OXT  sing N N 263 
PHE CB  CG   sing N N 264 
PHE CB  HB2  sing N N 265 
PHE CB  HB3  sing N N 266 
PHE CG  CD1  doub Y N 267 
PHE CG  CD2  sing Y N 268 
PHE CD1 CE1  sing Y N 269 
PHE CD1 HD1  sing N N 270 
PHE CD2 CE2  doub Y N 271 
PHE CD2 HD2  sing N N 272 
PHE CE1 CZ   doub Y N 273 
PHE CE1 HE1  sing N N 274 
PHE CE2 CZ   sing Y N 275 
PHE CE2 HE2  sing N N 276 
PHE CZ  HZ   sing N N 277 
PHE OXT HXT  sing N N 278 
PO4 P   O1   doub N N 279 
PO4 P   O2   sing N N 280 
PO4 P   O3   sing N N 281 
PO4 P   O4   sing N N 282 
PRO N   CA   sing N N 283 
PRO N   CD   sing N N 284 
PRO N   H    sing N N 285 
PRO CA  C    sing N N 286 
PRO CA  CB   sing N N 287 
PRO CA  HA   sing N N 288 
PRO C   O    doub N N 289 
PRO C   OXT  sing N N 290 
PRO CB  CG   sing N N 291 
PRO CB  HB2  sing N N 292 
PRO CB  HB3  sing N N 293 
PRO CG  CD   sing N N 294 
PRO CG  HG2  sing N N 295 
PRO CG  HG3  sing N N 296 
PRO CD  HD2  sing N N 297 
PRO CD  HD3  sing N N 298 
PRO OXT HXT  sing N N 299 
SER N   CA   sing N N 300 
SER N   H    sing N N 301 
SER N   H2   sing N N 302 
SER CA  C    sing N N 303 
SER CA  CB   sing N N 304 
SER CA  HA   sing N N 305 
SER C   O    doub N N 306 
SER C   OXT  sing N N 307 
SER CB  OG   sing N N 308 
SER CB  HB2  sing N N 309 
SER CB  HB3  sing N N 310 
SER OG  HG   sing N N 311 
SER OXT HXT  sing N N 312 
THR N   CA   sing N N 313 
THR N   H    sing N N 314 
THR N   H2   sing N N 315 
THR CA  C    sing N N 316 
THR CA  CB   sing N N 317 
THR CA  HA   sing N N 318 
THR C   O    doub N N 319 
THR C   OXT  sing N N 320 
THR CB  OG1  sing N N 321 
THR CB  CG2  sing N N 322 
THR CB  HB   sing N N 323 
THR OG1 HG1  sing N N 324 
THR CG2 HG21 sing N N 325 
THR CG2 HG22 sing N N 326 
THR CG2 HG23 sing N N 327 
THR OXT HXT  sing N N 328 
TRP N   CA   sing N N 329 
TRP N   H    sing N N 330 
TRP N   H2   sing N N 331 
TRP CA  C    sing N N 332 
TRP CA  CB   sing N N 333 
TRP CA  HA   sing N N 334 
TRP C   O    doub N N 335 
TRP C   OXT  sing N N 336 
TRP CB  CG   sing N N 337 
TRP CB  HB2  sing N N 338 
TRP CB  HB3  sing N N 339 
TRP CG  CD1  doub Y N 340 
TRP CG  CD2  sing Y N 341 
TRP CD1 NE1  sing Y N 342 
TRP CD1 HD1  sing N N 343 
TRP CD2 CE2  doub Y N 344 
TRP CD2 CE3  sing Y N 345 
TRP NE1 CE2  sing Y N 346 
TRP NE1 HE1  sing N N 347 
TRP CE2 CZ2  sing Y N 348 
TRP CE3 CZ3  doub Y N 349 
TRP CE3 HE3  sing N N 350 
TRP CZ2 CH2  doub Y N 351 
TRP CZ2 HZ2  sing N N 352 
TRP CZ3 CH2  sing Y N 353 
TRP CZ3 HZ3  sing N N 354 
TRP CH2 HH2  sing N N 355 
TRP OXT HXT  sing N N 356 
TYR N   CA   sing N N 357 
TYR N   H    sing N N 358 
TYR N   H2   sing N N 359 
TYR CA  C    sing N N 360 
TYR CA  CB   sing N N 361 
TYR CA  HA   sing N N 362 
TYR C   O    doub N N 363 
TYR C   OXT  sing N N 364 
TYR CB  CG   sing N N 365 
TYR CB  HB2  sing N N 366 
TYR CB  HB3  sing N N 367 
TYR CG  CD1  doub Y N 368 
TYR CG  CD2  sing Y N 369 
TYR CD1 CE1  sing Y N 370 
TYR CD1 HD1  sing N N 371 
TYR CD2 CE2  doub Y N 372 
TYR CD2 HD2  sing N N 373 
TYR CE1 CZ   doub Y N 374 
TYR CE1 HE1  sing N N 375 
TYR CE2 CZ   sing Y N 376 
TYR CE2 HE2  sing N N 377 
TYR CZ  OH   sing N N 378 
TYR OH  HH   sing N N 379 
TYR OXT HXT  sing N N 380 
VAL N   CA   sing N N 381 
VAL N   H    sing N N 382 
VAL N   H2   sing N N 383 
VAL CA  C    sing N N 384 
VAL CA  CB   sing N N 385 
VAL CA  HA   sing N N 386 
VAL C   O    doub N N 387 
VAL C   OXT  sing N N 388 
VAL CB  CG1  sing N N 389 
VAL CB  CG2  sing N N 390 
VAL CB  HB   sing N N 391 
VAL CG1 HG11 sing N N 392 
VAL CG1 HG12 sing N N 393 
VAL CG1 HG13 sing N N 394 
VAL CG2 HG21 sing N N 395 
VAL CG2 HG22 sing N N 396 
VAL CG2 HG23 sing N N 397 
VAL OXT HXT  sing N N 398 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3WD0 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 43 21 2' 
_space_group.name_Hall        'P 4nw 2abw' 
_space_group.IT_number        96 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YUG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010248 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010248 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005077 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A  1 3   ? -25.43677 -1.18780  36.61445  0.697 53.30180 ? 2    SER A N   1 
ATOM   2    C CA  . SER A  1 3   ? -26.34893 -2.08846  35.91626  0.697 55.88141 ? 2    SER A CA  1 
ATOM   3    C C   . SER A  1 3   ? -26.05998 -3.54234  36.27689  0.697 45.74836 ? 2    SER A C   1 
ATOM   4    O O   . SER A  1 3   ? -26.03119 -3.90539  37.45410  0.697 52.07318 ? 2    SER A O   1 
ATOM   5    C CB  . SER A  1 3   ? -26.24671 -1.89113  34.40043  0.697 56.72200 ? 2    SER A CB  1 
ATOM   6    O OG  . SER A  1 3   ? -24.93930 -1.49351  34.02086  0.697 61.09785 ? 2    SER A OG  1 
ATOM   7    N N   . THR A  1 4   ? -25.85719 -4.36973  35.25289  1.000 47.01517 ? 3    THR A N   1 
ATOM   8    C CA  . THR A  1 4   ? -25.50495 -5.76751  35.46724  1.000 44.18685 ? 3    THR A CA  1 
ATOM   9    C C   . THR A  1 4   ? -24.08100 -5.87111  36.00589  1.000 35.69183 ? 3    THR A C   1 
ATOM   10   O O   . THR A  1 4   ? -23.15789 -5.23054  35.48778  1.000 32.70974 ? 3    THR A O   1 
ATOM   11   C CB  . THR A  1 4   ? -25.63824 -6.55324  34.15969  1.000 46.36561 ? 3    THR A CB  1 
ATOM   12   O OG1 . THR A  1 4   ? -26.96327 -6.39279  33.63906  1.000 57.80377 ? 3    THR A OG1 1 
ATOM   13   C CG2 . THR A  1 4   ? -25.36201 -8.03673  34.37948  1.000 38.80512 ? 3    THR A CG2 1 
ATOM   14   N N   . ARG A  1 5   ? -23.90536 -6.67517  37.04908  1.000 28.85269 ? 4    ARG A N   1 
ATOM   15   C CA  . ARG A  1 5   ? -22.58646 -6.84735  37.64192  1.000 22.96268 ? 4    ARG A CA  1 
ATOM   16   C C   . ARG A  1 5   ? -21.61695 -7.46629  36.63743  1.000 22.95765 ? 4    ARG A C   1 
ATOM   17   O O   . ARG A  1 5   ? -21.95951 -8.42417  35.93892  1.000 28.21791 ? 4    ARG A O   1 
ATOM   18   C CB  . ARG A  1 5   ? -22.68916 -7.73152  38.87495  1.000 25.64818 ? 4    ARG A CB  1 
ATOM   19   C CG  . ARG A  1 5   ? -21.37176 -7.90871  39.58466  1.000 22.39048 ? 4    ARG A CG  1 
ATOM   20   C CD  . ARG A  1 5   ? -21.49701 -8.80631  40.79049  1.000 23.94651 ? 4    ARG A CD  1 
ATOM   21   N NE  . ARG A  1 5   ? -20.20959 -8.91907  41.46458  1.000 22.55053 ? 4    ARG A NE  1 
ATOM   22   C CZ  . ARG A  1 5   ? -20.01774 -9.57365  42.60129  1.000 23.48164 ? 4    ARG A CZ  1 
ATOM   23   N NH1 . ARG A  1 5   ? -21.01709 -10.17580 43.22833  1.000 25.94978 ? 4    ARG A NH1 1 
ATOM   24   N NH2 . ARG A  1 5   ? -18.79251 -9.62678  43.12052  1.000 22.47804 ? 4    ARG A NH2 1 
ATOM   25   N N   . LYS A  1 6   ? -20.40360 -6.92061  36.57442  1.000 20.38850 ? 5    LYS A N   1 
ATOM   26   C CA  . LYS A  1 6   ? -19.36341 -7.50274  35.73355  1.000 18.54575 ? 5    LYS A CA  1 
ATOM   27   C C   . LYS A  1 6   ? -18.87537 -8.82167  36.33011  1.000 17.95018 ? 5    LYS A C   1 
ATOM   28   O O   . LYS A  1 6   ? -18.62590 -8.92594  37.53955  1.000 19.55665 ? 5    LYS A O   1 
ATOM   29   C CB  . LYS A  1 6   ? -18.18870 -6.53405  35.57803  1.000 19.37247 ? 5    LYS A CB  1 
ATOM   30   C CG  . LYS A  1 6   ? -18.51959 -5.19878  34.89104  1.000 20.94352 ? 5    LYS A CG  1 
ATOM   31   C CD  . LYS A  1 6   ? -19.11453 -5.38987  33.51104  1.000 22.04602 ? 5    LYS A CD  1 
ATOM   32   C CE  . LYS A  1 6   ? -19.41615 -4.04374  32.84750  1.000 25.22971 ? 5    LYS A CE  1 
ATOM   33   N NZ  . LYS A  1 6   ? -20.15900 -4.19184  31.53972  1.000 24.06727 ? 5    LYS A NZ  1 
ATOM   34   N N   . ALA A  1 7   ? -18.73321 -9.83120  35.47330  1.000 17.02792 ? 6    ALA A N   1 
ATOM   35   C CA  . ALA A  1 7   ? -18.13888 -11.09280 35.88980  1.000 15.90011 ? 6    ALA A CA  1 
ATOM   36   C C   . ALA A  1 7   ? -16.69174 -10.87051 36.29786  1.000 16.06426 ? 6    ALA A C   1 
ATOM   37   O O   . ALA A  1 7   ? -15.98750 -10.03981 35.71726  1.000 17.03684 ? 6    ALA A O   1 
ATOM   38   C CB  . ALA A  1 7   ? -18.21136 -12.11342 34.74031  1.000 16.47584 ? 6    ALA A CB  1 
ATOM   39   N N   . VAL A  1 8   ? -16.26113 -11.59343 37.32706  1.000 15.62097 ? 7    VAL A N   1 
ATOM   40   C CA  . VAL A  1 8   ? -14.87317 -11.60037 37.78521  1.000 16.09411 ? 7    VAL A CA  1 
ATOM   41   C C   . VAL A  1 8   ? -14.53879 -13.06968 37.98119  1.000 15.52561 ? 7    VAL A C   1 
ATOM   42   O O   . VAL A  1 8   ? -14.93706 -13.68358 38.97676  1.000 17.09162 ? 7    VAL A O   1 
ATOM   43   C CB  . VAL A  1 8   ? -14.65859 -10.79368 39.07508  1.000 17.72460 ? 7    VAL A CB  1 
ATOM   44   C CG1 . VAL A  1 8   ? -13.20206 -10.94214 39.55884  1.000 16.68642 ? 7    VAL A CG1 1 
ATOM   45   C CG2 . VAL A  1 8   ? -15.00437 -9.32810  38.84194  1.000 18.11207 ? 7    VAL A CG2 1 
ATOM   46   N N   . ILE A  1 9   ? -13.82895 -13.64672 37.01734  1.000 14.98675 ? 8    ILE A N   1 
ATOM   47   C CA  . ILE A  1 9   ? -13.66176 -15.09282 36.89799  1.000 13.92827 ? 8    ILE A CA  1 
ATOM   48   C C   . ILE A  1 9   ? -12.20247 -15.42187 37.17592  1.000 15.11964 ? 8    ILE A C   1 
ATOM   49   O O   . ILE A  1 9   ? -11.32786 -15.08255 36.37430  1.000 13.83733 ? 8    ILE A O   1 
ATOM   50   C CB  . ILE A  1 9   ? -14.07437 -15.56069 35.49340  1.000 13.72543 ? 8    ILE A CB  1 
ATOM   51   C CG1 . ILE A  1 9   ? -15.50833 -15.09089 35.19002  1.000 15.02635 ? 8    ILE A CG1 1 
ATOM   52   C CG2 . ILE A  1 9   ? -13.88769 -17.07830 35.33743  1.000 15.97858 ? 8    ILE A CG2 1 
ATOM   53   C CD1 . ILE A  1 9   ? -16.04361 -15.60988 33.85644  1.000 16.50254 ? 8    ILE A CD1 1 
ATOM   54   N N   . GLY A  1 10  ? -11.91702 -16.08295 38.29484  1.000 15.61553 ? 9    GLY A N   1 
ATOM   55   C CA  . GLY A  1 10  ? -10.54792 -16.41059 38.66717  1.000 16.79136 ? 9    GLY A CA  1 
ATOM   56   C C   . GLY A  1 10  ? -10.29526 -17.90639 38.59695  1.000 14.69653 ? 9    GLY A C   1 
ATOM   57   O O   . GLY A  1 10  ? -11.06305 -18.69664 39.14033  1.000 16.82412 ? 9    GLY A O   1 
ATOM   58   N N   . TYR A  1 11  ? -9.21224  -18.28271 37.91338  1.000 14.44130 ? 10   TYR A N   1 
ATOM   59   C CA  . TYR A  1 11  ? -8.81957  -19.68670 37.89814  1.000 14.79698 ? 10   TYR A CA  1 
ATOM   60   C C   . TYR A  1 11  ? -8.23711  -20.10527 39.24105  1.000 15.89244 ? 10   TYR A C   1 
ATOM   61   O O   . TYR A  1 11  ? -7.41913  -19.38930 39.82529  1.000 16.19622 ? 10   TYR A O   1 
ATOM   62   C CB  . TYR A  1 11  ? -7.78213  -19.94267 36.81234  1.000 14.39610 ? 10   TYR A CB  1 
ATOM   63   C CG  . TYR A  1 11  ? -8.41426  -20.22197 35.47895  1.000 15.38578 ? 10   TYR A CG  1 
ATOM   64   C CD1 . TYR A  1 11  ? -8.77690  -19.17926 34.63763  1.000 15.15380 ? 10   TYR A CD1 1 
ATOM   65   C CD2 . TYR A  1 11  ? -8.65757  -21.53106 35.06473  1.000 14.41047 ? 10   TYR A CD2 1 
ATOM   66   C CE1 . TYR A  1 11  ? -9.36378  -19.44132 33.38680  1.000 14.44865 ? 10   TYR A CE1 1 
ATOM   67   C CE2 . TYR A  1 11  ? -9.24654  -21.79690 33.82865  1.000 15.49241 ? 10   TYR A CE2 1 
ATOM   68   C CZ  . TYR A  1 11  ? -9.60295  -20.74944 33.00882  1.000 15.50214 ? 10   TYR A CZ  1 
ATOM   69   O OH  . TYR A  1 11  ? -10.17988 -21.01594 31.77722  1.000 15.49711 ? 10   TYR A OH  1 
ATOM   70   N N   . TYR A  1 12  ? -8.65523  -21.28156 39.71962  1.000 14.79870 ? 11   TYR A N   1 
ATOM   71   C CA  . TYR A  1 12  ? -7.98666  -21.97713 40.81866  1.000 17.71812 ? 11   TYR A CA  1 
ATOM   72   C C   . TYR A  1 12  ? -7.35605  -23.21011 40.19886  1.000 16.83362 ? 11   TYR A C   1 
ATOM   73   O O   . TYR A  1 12  ? -8.06538  -24.13891 39.79441  1.000 17.06259 ? 11   TYR A O   1 
ATOM   74   C CB  . TYR A  1 12  ? -8.94916  -22.36044 41.94725  1.000 17.14472 ? 11   TYR A CB  1 
ATOM   75   C CG  . TYR A  1 12  ? -8.22334  -23.03593 43.11603  1.000 16.09043 ? 11   TYR A CG  1 
ATOM   76   C CD1 . TYR A  1 12  ? -7.61952  -22.27769 44.11883  1.000 19.25161 ? 11   TYR A CD1 1 
ATOM   77   C CD2 . TYR A  1 12  ? -8.11999  -24.42367 43.19667  1.000 17.81309 ? 11   TYR A CD2 1 
ATOM   78   C CE1 . TYR A  1 12  ? -6.93859  -22.88726 45.16671  1.000 19.60140 ? 11   TYR A CE1 1 
ATOM   79   C CE2 . TYR A  1 12  ? -7.44225  -25.04051 44.25342  1.000 18.36038 ? 11   TYR A CE2 1 
ATOM   80   C CZ  . TYR A  1 12  ? -6.85253  -24.26257 45.22571  1.000 19.34912 ? 11   TYR A CZ  1 
ATOM   81   O OH  . TYR A  1 12  ? -6.16442  -24.85816 46.26987  1.000 20.21255 ? 11   TYR A OH  1 
ATOM   82   N N   . PHE A  1 13  ? -6.03553  -23.20099 40.06663  1.000 17.04336 ? 12   PHE A N   1 
ATOM   83   C CA  . PHE A  1 13  ? -5.33437  -24.31459 39.44793  1.000 17.86441 ? 12   PHE A CA  1 
ATOM   84   C C   . PHE A  1 13  ? -4.61443  -25.10143 40.52902  1.000 19.93352 ? 12   PHE A C   1 
ATOM   85   O O   . PHE A  1 13  ? -3.88316  -24.52500 41.34681  1.000 20.09835 ? 12   PHE A O   1 
ATOM   86   C CB  . PHE A  1 13  ? -4.33297  -23.85521 38.39202  1.000 19.32727 ? 12   PHE A CB  1 
ATOM   87   C CG  . PHE A  1 13  ? -3.46950  -24.97310 37.88910  1.000 19.86443 ? 12   PHE A CG  1 
ATOM   88   C CD1 . PHE A  1 13  ? -4.02812  -26.00926 37.15420  1.000 19.28035 ? 12   PHE A CD1 1 
ATOM   89   C CD2 . PHE A  1 13  ? -2.11987  -25.02440 38.19872  1.000 24.36843 ? 12   PHE A CD2 1 
ATOM   90   C CE1 . PHE A  1 13  ? -3.25442  -27.06643 36.70799  1.000 20.86317 ? 12   PHE A CE1 1 
ATOM   91   C CE2 . PHE A  1 13  ? -1.33489  -26.07541 37.75265  1.000 27.96053 ? 12   PHE A CE2 1 
ATOM   92   C CZ  . PHE A  1 13  ? -1.90459  -27.10197 37.01160  1.000 26.54046 ? 12   PHE A CZ  1 
ATOM   93   N N   . ILE A  1 14  ? -4.81402  -26.41253 40.53397  1.000 18.01050 ? 13   ILE A N   1 
ATOM   94   C CA  . ILE A  1 14  ? -4.08822  -27.23533 41.50049  1.000 18.34030 ? 13   ILE A CA  1 
ATOM   95   C C   . ILE A  1 14  ? -3.66166  -28.52013 40.80117  1.000 18.39365 ? 13   ILE A C   1 
ATOM   96   O O   . ILE A  1 14  ? -4.50179  -29.24559 40.24818  1.000 19.65836 ? 13   ILE A O   1 
ATOM   97   C CB  . ILE A  1 14  ? -4.92300  -27.48788 42.77169  1.000 18.49158 ? 13   ILE A CB  1 
ATOM   98   C CG1 . ILE A  1 14  ? -4.10228  -28.28092 43.80632  1.000 18.80168 ? 13   ILE A CG1 1 
ATOM   99   C CG2 . ILE A  1 14  ? -6.27044  -28.14402 42.45754  1.000 19.54725 ? 13   ILE A CG2 1 
ATOM   100  C CD1 . ILE A  1 14  ? -4.76508  -28.36648 45.20565  1.000 17.92425 ? 13   ILE A CD1 1 
ATOM   101  N N   . PRO A  1 15  ? -2.36702  -28.81330 40.75141  1.000 19.63661 ? 14   PRO A N   1 
ATOM   102  C CA  . PRO A  1 15  ? -1.91606  -30.03657 40.07623  1.000 18.94615 ? 14   PRO A CA  1 
ATOM   103  C C   . PRO A  1 15  ? -2.28614  -31.26758 40.88329  1.000 18.40385 ? 14   PRO A C   1 
ATOM   104  O O   . PRO A  1 15  ? -2.55369  -31.19985 42.08273  1.000 22.16022 ? 14   PRO A O   1 
ATOM   105  C CB  . PRO A  1 15  ? -0.39525  -29.87310 39.98372  1.000 25.84076 ? 14   PRO A CB  1 
ATOM   106  C CG  . PRO A  1 15  ? -0.04136  -28.79684 40.93327  1.000 30.91877 ? 14   PRO A CG  1 
ATOM   107  C CD  . PRO A  1 15  ? -1.25512  -27.92271 41.11787  1.000 22.46701 ? 14   PRO A CD  1 
ATOM   108  N N   . THR A  1 16  ? -2.28477  -32.41015 40.19020  1.000 19.96185 ? 15   THR A N   1 
ATOM   109  C CA  . THR A  1 16  ? -2.71935  -33.65903 40.80108  1.000 18.91721 ? 15   THR A CA  1 
ATOM   110  C C   . THR A  1 16  ? -1.91184  -33.98891 42.05177  1.000 18.36182 ? 15   THR A C   1 
ATOM   111  O O   . THR A  1 16  ? -2.47068  -34.44441 43.05719  1.000 22.62329 ? 15   THR A O   1 
ATOM   112  C CB  . THR A  1 16  ? -2.61245  -34.79757 39.78453  1.000 24.39934 ? 15   THR A CB  1 
ATOM   113  O OG1 . THR A  1 16  ? -3.39091  -34.47703 38.62323  1.000 22.72286 ? 15   THR A OG1 1 
ATOM   114  C CG2 . THR A  1 16  ? -3.12873  -36.09433 40.38500  1.000 22.15422 ? 15   THR A CG2 1 
ATOM   115  N N   . ASN A  1 17  ? -0.59443  -33.78210 42.01281  1.000 20.75448 ? 16   ASN A N   1 
ATOM   116  C CA  . ASN A  1 17  ? 0.19683   -34.13718 43.19386  1.000 21.27971 ? 16   ASN A CA  1 
ATOM   117  C C   . ASN A  1 17  ? -0.17393  -33.27918 44.40094  1.000 25.75328 ? 16   ASN A C   1 
ATOM   118  O O   . ASN A  1 17  ? -0.07038  -33.73927 45.54331  1.000 25.71370 ? 16   ASN A O   1 
ATOM   119  C CB  . ASN A  1 17  ? 1.68791   -34.02707 42.88485  1.000 28.89355 ? 16   ASN A CB  1 
ATOM   120  C CG  . ASN A  1 17  ? 2.19697   -32.60251 42.96717  1.000 48.71451 ? 16   ASN A CG  1 
ATOM   121  O OD1 . ASN A  1 17  ? 1.77915   -31.73951 42.19923  1.000 37.10182 ? 16   ASN A OD1 1 
ATOM   122  N ND2 . ASN A  1 17  ? 3.09874   -32.34512 43.91444  1.000 61.42431 ? 16   ASN A ND2 1 
ATOM   123  N N   . GLN A  1 18  ? -0.62095  -32.04235 44.18260  1.000 22.11439 ? 17   GLN A N   1 
ATOM   124  C CA  . GLN A  1 18  ? -1.07246  -31.22004 45.30040  1.000 20.70305 ? 17   GLN A CA  1 
ATOM   125  C C   . GLN A  1 18  ? -2.44287  -31.64365 45.80612  1.000 20.73708 ? 17   GLN A C   1 
ATOM   126  O O   . GLN A  1 18  ? -2.69692  -31.57645 47.01448  1.000 24.44088 ? 17   GLN A O   1 
ATOM   127  C CB  . GLN A  1 18  ? -1.07060  -29.74366 44.89973  1.000 22.26572 ? 17   GLN A CB  1 
ATOM   128  C CG  . GLN A  1 18  ? 0.33645   -29.19210 44.71766  1.000 23.76385 ? 17   GLN A CG  1 
ATOM   129  C CD  . GLN A  1 18  ? 0.35528   -27.70709 44.42551  1.000 20.80544 ? 17   GLN A CD  1 
ATOM   130  O OE1 . GLN A  1 18  ? -0.51334  -26.96183 44.88029  1.000 21.89684 ? 17   GLN A OE1 1 
ATOM   131  N NE2 . GLN A  1 18  ? 1.34113   -27.27016 43.64371  1.000 23.56000 ? 17   GLN A NE2 1 
ATOM   132  N N   . ILE A  1 19  ? -3.33678  -32.08585 44.91734  1.000 20.85578 ? 18   ILE A N   1 
ATOM   133  C CA  . ILE A  1 19  ? -4.59219  -32.67094 45.37718  1.000 16.56415 ? 18   ILE A CA  1 
ATOM   134  C C   . ILE A  1 19  ? -4.30376  -33.88881 46.24020  1.000 21.71616 ? 18   ILE A C   1 
ATOM   135  O O   . ILE A  1 19  ? -4.83216  -34.02997 47.34916  1.000 23.16759 ? 18   ILE A O   1 
ATOM   136  C CB  . ILE A  1 19  ? -5.48999  -33.04549 44.18298  1.000 22.28265 ? 18   ILE A CB  1 
ATOM   137  C CG1 . ILE A  1 19  ? -6.00784  -31.78195 43.50020  1.000 20.35062 ? 18   ILE A CG1 1 
ATOM   138  C CG2 . ILE A  1 19  ? -6.63648  -33.95190 44.64292  1.000 21.73480 ? 18   ILE A CG2 1 
ATOM   139  C CD1 . ILE A  1 19  ? -6.65840  -32.05243 42.14587  1.000 23.96358 ? 18   ILE A CD1 1 
ATOM   140  N N   . ASN A  1 20  ? -3.44804  -34.78288 45.73666  1.000 22.70857 ? 19   ASN A N   1 
ATOM   141  C CA  . ASN A  1 20  ? -3.18623  -36.05153 46.40860  1.000 21.44083 ? 19   ASN A CA  1 
ATOM   142  C C   . ASN A  1 20  ? -2.49319  -35.86791 47.74425  1.000 28.36809 ? 19   ASN A C   1 
ATOM   143  O O   . ASN A  1 20  ? -2.57909  -36.75702 48.59672  1.000 27.00360 ? 19   ASN A O   1 
ATOM   144  C CB  . ASN A  1 20  ? -2.33961  -36.94417 45.51664  1.000 20.29021 ? 19   ASN A CB  1 
ATOM   145  C CG  . ASN A  1 20  ? -3.12341  -37.47887 44.33905  1.000 26.36340 ? 19   ASN A CG  1 
ATOM   146  O OD1 . ASN A  1 20  ? -4.33551  -37.27980 44.25350  1.000 25.23731 ? 19   ASN A OD1 1 
ATOM   147  N ND2 . ASN A  1 20  ? -2.44297  -38.17291 43.43601  1.000 26.28032 ? 19   ASN A ND2 1 
ATOM   148  N N   . ASN A  1 21  ? -1.81236  -34.74416 47.93723  1.000 21.77642 ? 20   ASN A N   1 
ATOM   149  C CA  . ASN A  1 21  ? -1.13025  -34.42646 49.18616  1.000 21.55375 ? 20   ASN A CA  1 
ATOM   150  C C   . ASN A  1 21  ? -1.70994  -33.17103 49.82794  1.000 26.91644 ? 20   ASN A C   1 
ATOM   151  O O   . ASN A  1 21  ? -1.00539  -32.44139 50.53506  1.000 24.42960 ? 20   ASN A O   1 
ATOM   152  C CB  . ASN A  1 21  ? 0.36683   -34.27116 48.93233  1.000 24.44469 ? 20   ASN A CB  1 
ATOM   153  C CG  . ASN A  1 21  ? 1.00113   -35.55548 48.43415  1.000 30.96947 ? 20   ASN A CG  1 
ATOM   154  O OD1 . ASN A  1 21  ? 1.24020   -35.73421 47.23170  1.000 32.47208 ? 20   ASN A OD1 1 
ATOM   155  N ND2 . ASN A  1 21  ? 1.25356   -36.47157 49.35427  1.000 31.90286 ? 20   ASN A ND2 1 
ATOM   156  N N   . TYR A  1 22  ? -3.00317  -32.92646 49.61156  1.000 22.86232 ? 21   TYR A N   1 
ATOM   157  C CA  . TYR A  1 22  ? -3.59219  -31.64062 49.96493  1.000 25.63337 ? 21   TYR A CA  1 
ATOM   158  C C   . TYR A  1 22  ? -3.44308  -31.34791 51.44931  1.000 26.57083 ? 21   TYR A C   1 
ATOM   159  O O   . TYR A  1 22  ? -3.75773  -32.18360 52.30632  1.000 24.33066 ? 21   TYR A O   1 
ATOM   160  C CB  . TYR A  1 22  ? -5.07051  -31.58377 49.59310  1.000 22.76182 ? 21   TYR A CB  1 
ATOM   161  C CG  . TYR A  1 22  ? -5.65636  -30.20201 49.80286  1.000 22.35007 ? 21   TYR A CG  1 
ATOM   162  C CD1 . TYR A  1 22  ? -5.38561  -29.17410 48.90349  1.000 19.04619 ? 21   TYR A CD1 1 
ATOM   163  C CD2 . TYR A  1 22  ? -6.44955  -29.91421 50.91224  1.000 22.81195 ? 21   TYR A CD2 1 
ATOM   164  C CE1 . TYR A  1 22  ? -5.90393  -27.89974 49.08978  1.000 21.18323 ? 21   TYR A CE1 1 
ATOM   165  C CE2 . TYR A  1 22  ? -6.97737  -28.64582 51.10852  1.000 20.96325 ? 21   TYR A CE2 1 
ATOM   166  C CZ  . TYR A  1 22  ? -6.69971  -27.63846 50.18756  1.000 19.76135 ? 21   TYR A CZ  1 
ATOM   167  O OH  . TYR A  1 22  ? -7.22103  -26.37801 50.38106  1.000 20.85887 ? 21   TYR A OH  1 
ATOM   168  N N   . THR A  1 23  ? -2.99324  -30.13375 51.73731  1.000 21.33826 ? 22   THR A N   1 
ATOM   169  C CA  . THR A  1 23  ? -2.85606  -29.63697 53.09443  1.000 24.46344 ? 22   THR A CA  1 
ATOM   170  C C   . THR A  1 23  ? -2.98444  -28.12480 53.05500  1.000 23.69766 ? 22   THR A C   1 
ATOM   171  O O   . THR A  1 23  ? -2.56730  -27.47913 52.08929  1.000 25.44235 ? 22   THR A O   1 
ATOM   172  C CB  . THR A  1 23  ? -1.50464  -30.02232 53.70659  1.000 25.85497 ? 22   THR A CB  1 
ATOM   173  O OG1 . THR A  1 23  ? -1.34470  -29.34212 54.96018  1.000 25.74011 ? 22   THR A OG1 1 
ATOM   174  C CG2 . THR A  1 23  ? -0.37219  -29.62802 52.77060  1.000 24.84835 ? 22   THR A CG2 1 
ATOM   175  N N   . GLU A  1 24  ? -3.54983  -27.56256 54.11408  1.000 21.90965 ? 23   GLU A N   1 
ATOM   176  C CA  . GLU A  1 24  ? -3.69422  -26.12080 54.21721  1.000 22.02113 ? 23   GLU A CA  1 
ATOM   177  C C   . GLU A  1 24  ? -2.64789  -25.49551 55.11882  1.000 25.99586 ? 23   GLU A C   1 
ATOM   178  O O   . GLU A  1 24  ? -2.70798  -24.29185 55.38220  1.000 28.46722 ? 23   GLU A O   1 
ATOM   179  C CB  . GLU A  1 24  ? -5.09693  -25.78640 54.69322  1.000 25.66564 ? 23   GLU A CB  1 
ATOM   180  C CG  . GLU A  1 24  ? -6.12237  -26.41141 53.76927  1.000 30.44503 ? 23   GLU A CG  1 
ATOM   181  C CD  . GLU A  1 24  ? -7.43630  -25.70473 53.79053  1.000 33.84335 ? 23   GLU A CD  1 
ATOM   182  O OE1 . GLU A  1 24  ? -7.89286  -25.34509 54.88970  1.000 30.98813 ? 23   GLU A OE1 1 
ATOM   183  O OE2 . GLU A  1 24  ? -8.02013  -25.51358 52.71032  1.000 25.48874 ? 23   GLU A OE2 1 
ATOM   184  N N   . THR A  1 25  ? -1.67420  -26.27824 55.57517  1.000 27.64923 ? 24   THR A N   1 
ATOM   185  C CA  . THR A  1 25  ? -0.71767  -25.79113 56.56067  1.000 27.23366 ? 24   THR A CA  1 
ATOM   186  C C   . THR A  1 25  ? 0.72887   -26.02064 56.14154  1.000 34.48401 ? 24   THR A C   1 
ATOM   187  O O   . THR A  1 25  ? 1.61876   -26.03602 56.99981  1.000 27.79607 ? 24   THR A O   1 
ATOM   188  C CB  . THR A  1 25  ? -0.98400  -26.45091 57.91597  1.000 25.24320 ? 24   THR A CB  1 
ATOM   189  O OG1 . THR A  1 25  ? -0.82066  -27.86603 57.78294  1.000 28.42761 ? 24   THR A OG1 1 
ATOM   190  C CG2 . THR A  1 25  ? -2.39199  -26.15167 58.39151  1.000 31.85659 ? 24   THR A CG2 1 
ATOM   191  N N   . ASP A  1 26  ? 0.99813   -26.18924 54.84668  1.000 25.78475 ? 25   ASP A N   1 
ATOM   192  C CA  . ASP A  1 26  ? 2.37420   -26.38082 54.39878  1.000 22.63165 ? 25   ASP A CA  1 
ATOM   193  C C   . ASP A  1 26  ? 2.48170   -25.84371 52.97664  1.000 26.04119 ? 25   ASP A C   1 
ATOM   194  O O   . ASP A  1 26  ? 2.21397   -26.57606 52.02149  1.000 24.33277 ? 25   ASP A O   1 
ATOM   195  C CB  . ASP A  1 26  ? 2.78471   -27.84770 54.46725  1.000 24.58645 ? 25   ASP A CB  1 
ATOM   196  C CG  . ASP A  1 26  ? 4.26049   -28.05675 54.19329  1.000 27.70362 ? 25   ASP A CG  1 
ATOM   197  O OD1 . ASP A  1 26  ? 4.93269   -27.14215 53.66632  1.000 27.68891 ? 25   ASP A OD1 1 
ATOM   198  O OD2 . ASP A  1 26  ? 4.76247   -29.15487 54.50861  1.000 32.41391 ? 25   ASP A OD2 1 
ATOM   199  N N   . THR A  1 27  ? 2.93257   -24.59559 52.84497  1.000 25.19785 ? 26   THR A N   1 
ATOM   200  C CA  . THR A  1 27  ? 3.05393   -24.01203 51.51492  1.000 25.30968 ? 26   THR A CA  1 
ATOM   201  C C   . THR A  1 27  ? 4.13120   -24.67422 50.66699  1.000 24.72453 ? 26   THR A C   1 
ATOM   202  O O   . THR A  1 27  ? 4.18210   -24.40939 49.46324  1.000 25.15608 ? 26   THR A O   1 
ATOM   203  C CB  . THR A  1 27  ? 3.32948   -22.50625 51.60438  1.000 30.68699 ? 26   THR A CB  1 
ATOM   204  O OG1 . THR A  1 27  ? 4.52736   -22.27587 52.35919  1.000 31.96017 ? 26   THR A OG1 1 
ATOM   205  C CG2 . THR A  1 27  ? 2.17085   -21.79723 52.27350  1.000 34.78246 ? 26   THR A CG2 1 
ATOM   206  N N   . SER A  1 28  ? 5.00132   -25.51570 51.24371  1.000 23.65676 ? 27   SER A N   1 
ATOM   207  C CA  . SER A  1 28  ? 5.95767   -26.22483 50.40213  1.000 25.19643 ? 27   SER A CA  1 
ATOM   208  C C   . SER A  1 28  ? 5.31604   -27.41480 49.70205  1.000 21.36427 ? 27   SER A C   1 
ATOM   209  O O   . SER A  1 28  ? 5.88626   -27.93072 48.73405  1.000 28.59419 ? 27   SER A O   1 
ATOM   210  C CB  . SER A  1 28  ? 7.17997   -26.68547 51.21539  1.000 29.99883 ? 27   SER A CB  1 
ATOM   211  O OG  . SER A  1 28  ? 6.88831   -27.81107 52.03176  1.000 33.09983 ? 27   SER A OG  1 
ATOM   212  N N   . VAL A  1 29  ? 4.14984   -27.84841 50.16826  1.000 24.15451 ? 28   VAL A N   1 
ATOM   213  C CA  . VAL A  1 29  ? 3.37945   -28.91140 49.52775  1.000 23.05343 ? 28   VAL A CA  1 
ATOM   214  C C   . VAL A  1 29  ? 2.25862   -28.33570 48.67326  1.000 23.10505 ? 28   VAL A C   1 
ATOM   215  O O   . VAL A  1 29  ? 2.12944   -28.67770 47.49744  1.000 25.07257 ? 28   VAL A O   1 
ATOM   216  C CB  . VAL A  1 29  ? 2.82159   -29.88990 50.58410  1.000 27.41979 ? 28   VAL A CB  1 
ATOM   217  C CG1 . VAL A  1 29  ? 1.96004   -30.95007 49.91945  1.000 26.83456 ? 28   VAL A CG1 1 
ATOM   218  C CG2 . VAL A  1 29  ? 3.96329   -30.53608 51.38796  1.000 28.39467 ? 28   VAL A CG2 1 
ATOM   219  N N   . VAL A  1 30  ? 1.44056   -27.46908 49.25534  1.000 21.60708 ? 29   VAL A N   1 
ATOM   220  C CA  . VAL A  1 30  ? 0.39397   -26.74869 48.54191  1.000 20.02314 ? 29   VAL A CA  1 
ATOM   221  C C   . VAL A  1 30  ? 0.60835   -25.25605 48.75960  1.000 19.75986 ? 29   VAL A C   1 
ATOM   222  O O   . VAL A  1 30  ? 0.25264   -24.71579 49.80509  1.000 21.46121 ? 29   VAL A O   1 
ATOM   223  C CB  . VAL A  1 30  ? -1.00895  -27.17275 49.01043  1.000 19.93357 ? 29   VAL A CB  1 
ATOM   224  C CG1 . VAL A  1 30  ? -2.07501  -26.42860 48.19112  1.000 23.48987 ? 29   VAL A CG1 1 
ATOM   225  C CG2 . VAL A  1 30  ? -1.18764  -28.67413 48.87197  1.000 21.20066 ? 29   VAL A CG2 1 
ATOM   226  N N   . PRO A  1 31  ? 1.18410   -24.54845 47.78310  1.000 20.43257 ? 30   PRO A N   1 
ATOM   227  C CA  . PRO A  1 31  ? 1.39780   -23.10280 47.97576  1.000 20.03985 ? 30   PRO A CA  1 
ATOM   228  C C   . PRO A  1 31  ? 0.12027   -22.30905 48.19620  1.000 20.88299 ? 30   PRO A C   1 
ATOM   229  O O   . PRO A  1 31  ? 0.13216   -21.34233 48.96804  1.000 21.71727 ? 30   PRO A O   1 
ATOM   230  C CB  . PRO A  1 31  ? 2.10956   -22.67765 46.68521  1.000 22.97315 ? 30   PRO A CB  1 
ATOM   231  C CG  . PRO A  1 31  ? 2.79978   -23.93669 46.21124  1.000 24.05644 ? 30   PRO A CG  1 
ATOM   232  C CD  . PRO A  1 31  ? 1.88419   -25.06473 46.59546  1.000 22.25044 ? 30   PRO A CD  1 
ATOM   233  N N   . PHE A  1 32  ? -0.98587  -22.66590 47.54087  1.000 19.67190 ? 31   PHE A N   1 
ATOM   234  C CA  . PHE A  1 32  ? -2.19222  -21.83800 47.56031  1.000 18.21562 ? 31   PHE A CA  1 
ATOM   235  C C   . PHE A  1 32  ? -3.39793  -22.71556 47.85943  1.000 18.39768 ? 31   PHE A C   1 
ATOM   236  O O   . PHE A  1 32  ? -4.18514  -23.05442 46.96549  1.000 20.36929 ? 31   PHE A O   1 
ATOM   237  C CB  . PHE A  1 32  ? -2.35808  -21.06183 46.24294  1.000 17.97859 ? 31   PHE A CB  1 
ATOM   238  C CG  . PHE A  1 32  ? -3.42760  -19.99943 46.30684  1.000 19.25740 ? 31   PHE A CG  1 
ATOM   239  C CD1 . PHE A  1 32  ? -3.23192  -18.83454 47.04158  1.000 16.49787 ? 31   PHE A CD1 1 
ATOM   240  C CD2 . PHE A  1 32  ? -4.63536  -20.17348 45.63951  1.000 20.64575 ? 31   PHE A CD2 1 
ATOM   241  C CE1 . PHE A  1 32  ? -4.22169  -17.85711 47.11043  1.000 16.64454 ? 31   PHE A CE1 1 
ATOM   242  C CE2 . PHE A  1 32  ? -5.62580  -19.20634 45.70604  1.000 21.11372 ? 31   PHE A CE2 1 
ATOM   243  C CZ  . PHE A  1 32  ? -5.42083  -18.04818 46.45170  1.000 20.56712 ? 31   PHE A CZ  1 
ATOM   244  N N   . PRO A  1 33  ? -3.58769  -23.08835 49.12149  1.000 18.53788 ? 32   PRO A N   1 
ATOM   245  C CA  . PRO A  1 33  ? -4.76666  -23.87474 49.48705  1.000 16.21558 ? 32   PRO A CA  1 
ATOM   246  C C   . PRO A  1 33  ? -6.02703  -23.02687 49.44296  1.000 16.86439 ? 32   PRO A C   1 
ATOM   247  O O   . PRO A  1 33  ? -5.98429  -21.79408 49.43809  1.000 18.84161 ? 32   PRO A O   1 
ATOM   248  C CB  . PRO A  1 33  ? -4.45402  -24.32931 50.91956  1.000 19.04564 ? 32   PRO A CB  1 
ATOM   249  C CG  . PRO A  1 33  ? -3.62706  -23.18601 51.46841  1.000 19.74871 ? 32   PRO A CG  1 
ATOM   250  C CD  . PRO A  1 33  ? -2.76616  -22.73429 50.29402  1.000 16.01138 ? 32   PRO A CD  1 
ATOM   251  N N   . VAL A  1 34  ? -7.17059  -23.72099 49.44215  1.000 19.40959 ? 33   VAL A N   1 
ATOM   252  C CA  . VAL A  1 34  ? -8.45917  -23.05015 49.30680  1.000 18.12517 ? 33   VAL A CA  1 
ATOM   253  C C   . VAL A  1 34  ? -8.69152  -22.05867 50.44217  1.000 19.61931 ? 33   VAL A C   1 
ATOM   254  O O   . VAL A  1 34  ? -9.32614  -21.01638 50.24272  1.000 20.51514 ? 33   VAL A O   1 
ATOM   255  C CB  . VAL A  1 34  ? -9.58917  -24.09860 49.20943  1.000 19.12223 ? 33   VAL A CB  1 
ATOM   256  C CG1 . VAL A  1 34  ? -10.95985 -23.41679 49.15037  1.000 20.59380 ? 33   VAL A CG1 1 
ATOM   257  C CG2 . VAL A  1 34  ? -9.38114  -24.98969 47.97602  1.000 20.21834 ? 33   VAL A CG2 1 
ATOM   258  N N   . SER A  1 35  ? -8.15180  -22.33234 51.63863  1.000 20.99931 ? 34   SER A N   1 
ATOM   259  C CA  . SER A  1 35  ? -8.34735  -21.42501 52.76539  1.000 21.33582 ? 34   SER A CA  1 
ATOM   260  C C   . SER A  1 35  ? -7.73183  -20.04565 52.53388  1.000 22.73612 ? 34   SER A C   1 
ATOM   261  O O   . SER A  1 35  ? -8.07547  -19.10005 53.25050  1.000 21.96604 ? 34   SER A O   1 
ATOM   262  C CB  . SER A  1 35  ? -7.76182  -22.04926 54.03795  1.000 22.99261 ? 34   SER A CB  1 
ATOM   263  O OG  . SER A  1 35  ? -6.39530  -22.37440 53.82960  1.000 25.10336 ? 34   SER A OG  1 
ATOM   264  N N   . ASN A  1 36  ? -6.83383  -19.89774 51.55572  1.000 19.49848 ? 35   ASN A N   1 
ATOM   265  C CA  . ASN A  1 36  ? -6.33490  -18.56807 51.21870  1.000 17.82982 ? 35   ASN A CA  1 
ATOM   266  C C   . ASN A  1 36  ? -7.35564  -17.73831 50.45021  1.000 18.17440 ? 35   ASN A C   1 
ATOM   267  O O   . ASN A  1 36  ? -7.16326  -16.52423 50.30522  1.000 20.48457 ? 35   ASN A O   1 
ATOM   268  C CB  . ASN A  1 36  ? -5.04695  -18.66957 50.40205  1.000 19.59308 ? 35   ASN A CB  1 
ATOM   269  C CG  . ASN A  1 36  ? -3.87957  -19.17482 51.21259  1.000 24.20972 ? 35   ASN A CG  1 
ATOM   270  O OD1 . ASN A  1 36  ? -4.04820  -19.67955 52.32794  1.000 29.85473 ? 35   ASN A OD1 1 
ATOM   271  N ND2 . ASN A  1 36  ? -2.68520  -19.05347 50.65822  1.000 20.73051 ? 35   ASN A ND2 1 
ATOM   272  N N   . ILE A  1 37  ? -8.42678  -18.35380 49.95117  1.000 18.85562 ? 36   ILE A N   1 
ATOM   273  C CA  . ILE A  1 37  ? -9.54348  -17.60454 49.37079  1.000 19.32750 ? 36   ILE A CA  1 
ATOM   274  C C   . ILE A  1 37  ? -10.45420 -17.25320 50.54274  1.000 22.36514 ? 36   ILE A C   1 
ATOM   275  O O   . ILE A  1 37  ? -11.37071 -17.99833 50.89735  1.000 19.73735 ? 36   ILE A O   1 
ATOM   276  C CB  . ILE A  1 37  ? -10.26851 -18.39260 48.28624  1.000 19.43213 ? 36   ILE A CB  1 
ATOM   277  C CG1 . ILE A  1 37  ? -9.27361  -18.88117 47.23719  1.000 20.77122 ? 36   ILE A CG1 1 
ATOM   278  C CG2 . ILE A  1 37  ? -11.32908 -17.50743 47.65002  1.000 18.96303 ? 36   ILE A CG2 1 
ATOM   279  C CD1 . ILE A  1 37  ? -9.89115  -19.85076 46.22830  1.000 21.52383 ? 36   ILE A CD1 1 
ATOM   280  N N   . THR A  1 38  ? -10.18260 -16.10176 51.15692  1.000 20.44995 ? 37   THR A N   1 
ATOM   281  C CA  . THR A  1 38  ? -10.92484 -15.64304 52.32834  1.000 20.97673 ? 37   THR A CA  1 
ATOM   282  C C   . THR A  1 38  ? -12.34668 -15.24659 51.94785  1.000 25.47227 ? 37   THR A C   1 
ATOM   283  O O   . THR A  1 38  ? -12.64666 -15.03089 50.77260  1.000 20.49258 ? 37   THR A O   1 
ATOM   284  C CB  . THR A  1 38  ? -10.22852 -14.43233 52.93710  1.000 21.18014 ? 37   THR A CB  1 
ATOM   285  O OG1 . THR A  1 38  ? -10.14416 -13.41077 51.93303  1.000 25.52583 ? 37   THR A OG1 1 
ATOM   286  C CG2 . THR A  1 38  ? -8.83174  -14.80113 53.39017  1.000 25.15350 ? 37   THR A CG2 1 
ATOM   287  N N   . PRO A  1 39  ? -13.23743 -15.10716 52.93002  1.000 21.60754 ? 38   PRO A N   1 
ATOM   288  C CA  . PRO A  1 39  ? -14.57668 -14.58669 52.61405  1.000 19.09019 ? 38   PRO A CA  1 
ATOM   289  C C   . PRO A  1 39  ? -14.55043 -13.29169 51.82153  1.000 21.11680 ? 38   PRO A C   1 
ATOM   290  O O   . PRO A  1 39  ? -15.35927 -13.12450 50.89930  1.000 21.59873 ? 38   PRO A O   1 
ATOM   291  C CB  . PRO A  1 39  ? -15.20422 -14.40780 54.00373  1.000 25.73856 ? 38   PRO A CB  1 
ATOM   292  C CG  . PRO A  1 39  ? -14.57481 -15.49451 54.79802  1.000 25.07657 ? 38   PRO A CG  1 
ATOM   293  C CD  . PRO A  1 39  ? -13.14587 -15.56376 54.33227  1.000 24.50825 ? 38   PRO A CD  1 
ATOM   294  N N   . ALA A  1 40  ? -13.62361 -12.38069 52.14100  1.000 22.06169 ? 39   ALA A N   1 
ATOM   295  C CA  . ALA A  1 40  ? -13.53334 -11.12430 51.40434  1.000 23.16593 ? 39   ALA A CA  1 
ATOM   296  C C   . ALA A  1 40  ? -13.19650 -11.36337 49.93747  1.000 22.23453 ? 39   ALA A C   1 
ATOM   297  O O   . ALA A  1 40  ? -13.77013 -10.72111 49.04813  1.000 23.69480 ? 39   ALA A O   1 
ATOM   298  C CB  . ALA A  1 40  ? -12.48730 -10.21178 52.04235  1.000 25.36227 ? 39   ALA A CB  1 
ATOM   299  N N   . LYS A  1 41  ? -12.26008 -12.27534 49.66216  1.000 20.55912 ? 40   LYS A N   1 
ATOM   300  C CA  . LYS A  1 41  ? -11.94152 -12.58501 48.26726  1.000 19.68562 ? 40   LYS A CA  1 
ATOM   301  C C   . LYS A  1 41  ? -13.10141 -13.29256 47.57889  1.000 19.03894 ? 40   LYS A C   1 
ATOM   302  O O   . LYS A  1 41  ? -13.40238 -13.00786 46.41211  1.000 18.50050 ? 40   LYS A O   1 
ATOM   303  C CB  . LYS A  1 41  ? -10.67420 -13.43947 48.18850  1.000 20.94638 ? 40   LYS A CB  1 
ATOM   304  C CG  . LYS A  1 41  ? -9.43614  -12.70126 48.69674  1.000 23.38593 ? 40   LYS A CG  1 
ATOM   305  C CD  . LYS A  1 41  ? -8.19736  -13.59021 48.73766  1.000 22.82908 ? 40   LYS A CD  1 
ATOM   306  C CE  . LYS A  1 41  ? -7.13392  -12.93880 49.64238  1.000 30.78259 ? 40   LYS A CE  1 
ATOM   307  N NZ  . LYS A  1 41  ? -6.06153  -13.89353 50.04990  1.000 25.69224 ? 40   LYS A NZ  1 
ATOM   308  N N   . ALA A  1 42  ? -13.77060 -14.21109 48.28366  1.000 19.47353 ? 41   ALA A N   1 
ATOM   309  C CA  . ALA A  1 42  ? -14.90527 -14.91340 47.68781  1.000 19.97711 ? 41   ALA A CA  1 
ATOM   310  C C   . ALA A  1 42  ? -16.00267 -13.94236 47.27839  1.000 23.43843 ? 41   ALA A C   1 
ATOM   311  O O   . ALA A  1 42  ? -16.68427 -14.15013 46.26551  1.000 20.92752 ? 41   ALA A O   1 
ATOM   312  C CB  . ALA A  1 42  ? -15.44770 -15.96163 48.65929  1.000 20.16562 ? 41   ALA A CB  1 
ATOM   313  N N   A LYS A  1 43  ? -16.18583 -12.86624 48.04753  0.464 19.68815 ? 42   LYS A N   1 
ATOM   314  N N   B LYS A  1 43  ? -16.19085 -12.87283 48.05366  0.536 19.67137 ? 42   LYS A N   1 
ATOM   315  C CA  A LYS A  1 43  ? -17.20028 -11.87748 47.70747  0.464 18.40522 ? 42   LYS A CA  1 
ATOM   316  C CA  B LYS A  1 43  ? -17.19572 -11.87512 47.71537  0.536 18.38129 ? 42   LYS A CA  1 
ATOM   317  C C   A LYS A  1 43  ? -16.82720 -11.05221 46.48364  0.464 19.62341 ? 42   LYS A C   1 
ATOM   318  C C   B LYS A  1 43  ? -16.82656 -11.06142 46.48295  0.536 19.61527 ? 42   LYS A C   1 
ATOM   319  O O   A LYS A  1 43  ? -17.71846 -10.49776 45.83534  0.464 20.71327 ? 42   LYS A O   1 
ATOM   320  O O   B LYS A  1 43  ? -17.72169 -10.52624 45.82536  0.536 20.70164 ? 42   LYS A O   1 
ATOM   321  C CB  A LYS A  1 43  ? -17.45403 -10.95064 48.90078  0.464 20.42051 ? 42   LYS A CB  1 
ATOM   322  C CB  B LYS A  1 43  ? -17.42660 -10.94320 48.90752  0.536 20.38015 ? 42   LYS A CB  1 
ATOM   323  C CG  A LYS A  1 43  ? -18.33780 -11.57338 49.96603  0.464 24.53411 ? 42   LYS A CG  1 
ATOM   324  C CG  B LYS A  1 43  ? -18.04057 -11.64788 50.09917  0.536 24.78805 ? 42   LYS A CG  1 
ATOM   325  C CD  A LYS A  1 43  ? -18.47517 -10.66850 51.18607  0.464 24.56738 ? 42   LYS A CD  1 
ATOM   326  C CD  B LYS A  1 43  ? -18.03345 -10.75489 51.33334  0.536 24.63312 ? 42   LYS A CD  1 
ATOM   327  C CE  A LYS A  1 43  ? -19.22058 -11.38893 52.29240  0.464 32.33043 ? 42   LYS A CE  1 
ATOM   328  C CE  B LYS A  1 43  ? -18.62004 -11.48657 52.51561  0.536 31.81033 ? 42   LYS A CE  1 
ATOM   329  N NZ  A LYS A  1 43  ? -20.68175 -11.45043 52.02052  0.464 31.85393 ? 42   LYS A NZ  1 
ATOM   330  N NZ  B LYS A  1 43  ? -18.52414 -10.68531 53.76793  0.536 35.51025 ? 42   LYS A NZ  1 
ATOM   331  N N   . GLN A  1 44  ? -15.53950 -10.95525 46.15354  1.000 16.89296 ? 43   GLN A N   1 
ATOM   332  C CA  . GLN A  1 44  ? -15.09993 -10.17118 45.01243  1.000 15.11840 ? 43   GLN A CA  1 
ATOM   333  C C   . GLN A  1 44  ? -15.08362 -10.97912 43.72827  1.000 17.40525 ? 43   GLN A C   1 
ATOM   334  O O   . GLN A  1 44  ? -14.91760 -10.39412 42.65039  1.000 17.61138 ? 43   GLN A O   1 
ATOM   335  C CB  . GLN A  1 44  ? -13.70901 -9.59297  45.26425  1.000 17.67964 ? 43   GLN A CB  1 
ATOM   336  C CG  . GLN A  1 44  ? -13.69933 -8.59139  46.44060  1.000 19.04430 ? 43   GLN A CG  1 
ATOM   337  C CD  . GLN A  1 44  ? -12.31551 -8.34872  46.99728  1.000 26.25888 ? 43   GLN A CD  1 
ATOM   338  O OE1 . GLN A  1 44  ? -11.35616 -9.01276  46.60722  1.000 21.93428 ? 43   GLN A OE1 1 
ATOM   339  N NE2 . GLN A  1 44  ? -12.20386 -7.39987  47.93150  1.000 25.86159 ? 43   GLN A NE2 1 
ATOM   340  N N   . LEU A  1 45  ? -15.24900 -12.29011 43.83162  1.000 18.13346 ? 44   LEU A N   1 
ATOM   341  C CA  . LEU A  1 45  ? -15.31157 -13.17884 42.67773  1.000 17.95448 ? 44   LEU A CA  1 
ATOM   342  C C   . LEU A  1 45  ? -16.76205 -13.45594 42.30888  1.000 19.14484 ? 44   LEU A C   1 
ATOM   343  O O   . LEU A  1 45  ? -17.63146 -13.52984 43.18278  1.000 20.17240 ? 44   LEU A O   1 
ATOM   344  C CB  . LEU A  1 45  ? -14.60595 -14.49784 42.99569  1.000 16.00789 ? 44   LEU A CB  1 
ATOM   345  C CG  . LEU A  1 45  ? -13.08387 -14.39182 43.10315  1.000 15.02302 ? 44   LEU A CG  1 
ATOM   346  C CD1 . LEU A  1 45  ? -12.53880 -15.44664 44.06770  1.000 17.22486 ? 44   LEU A CD1 1 
ATOM   347  C CD2 . LEU A  1 45  ? -12.45571 -14.54295 41.69697  1.000 16.73832 ? 44   LEU A CD2 1 
ATOM   348  N N   . THR A  1 46  ? -17.02849 -13.61082 41.00359  1.000 15.83186 ? 45   THR A N   1 
ATOM   349  C CA  . THR A  1 46  ? -18.30371 -14.19111 40.59494  1.000 17.19414 ? 45   THR A CA  1 
ATOM   350  C C   . THR A  1 46  ? -18.16412 -15.64697 40.18838  1.000 19.27942 ? 45   THR A C   1 
ATOM   351  O O   . THR A  1 46  ? -19.12772 -16.40443 40.29548  1.000 17.29055 ? 45   THR A O   1 
ATOM   352  C CB  . THR A  1 46  ? -18.95083 -13.40017 39.43777  1.000 18.31679 ? 45   THR A CB  1 
ATOM   353  O OG1 . THR A  1 46  ? -18.13011 -13.44656 38.26440  1.000 17.15462 ? 45   THR A OG1 1 
ATOM   354  C CG2 . THR A  1 46  ? -19.16297 -11.93477 39.82480  1.000 17.64343 ? 45   THR A CG2 1 
ATOM   355  N N   . HIS A  1 47  ? -16.97737 -16.05570 39.75435  1.000 15.00178 ? 46   HIS A N   1 
ATOM   356  C CA  . HIS A  1 47  ? -16.71728 -17.40859 39.29785  1.000 15.45346 ? 46   HIS A CA  1 
ATOM   357  C C   . HIS A  1 47  ? -15.31261 -17.79544 39.71961  1.000 14.40647 ? 46   HIS A C   1 
ATOM   358  O O   . HIS A  1 47  ? -14.38710 -16.98750 39.60918  1.000 16.07741 ? 46   HIS A O   1 
ATOM   359  C CB  . HIS A  1 47  ? -16.78129 -17.54665 37.75698  1.000 14.88736 ? 46   HIS A CB  1 
ATOM   360  C CG  . HIS A  1 47  ? -18.09982 -17.18672 37.13612  1.000 17.65787 ? 46   HIS A CG  1 
ATOM   361  N ND1 . HIS A  1 47  ? -18.56304 -15.88985 37.05694  1.000 16.29131 ? 46   HIS A ND1 1 
ATOM   362  C CD2 . HIS A  1 47  ? -19.00961 -17.95035 36.47956  1.000 16.72913 ? 46   HIS A CD2 1 
ATOM   363  C CE1 . HIS A  1 47  ? -19.71142 -15.87195 36.39782  1.000 15.29051 ? 46   HIS A CE1 1 
ATOM   364  N NE2 . HIS A  1 47  ? -20.00809 -17.11115 36.04392  1.000 17.76913 ? 46   HIS A NE2 1 
ATOM   365  N N   . ILE A  1 48  ? -15.15681 -19.03104 40.17215  1.000 15.50418 ? 47   ILE A N   1 
ATOM   366  C CA  . ILE A  1 48  ? -13.85440 -19.67237 40.27977  1.000 14.24582 ? 47   ILE A CA  1 
ATOM   367  C C   . ILE A  1 48  ? -13.84301 -20.82735 39.28882  1.000 14.88114 ? 47   ILE A C   1 
ATOM   368  O O   . ILE A  1 48  ? -14.71567 -21.70320 39.34606  1.000 16.56653 ? 47   ILE A O   1 
ATOM   369  C CB  . ILE A  1 48  ? -13.57684 -20.16704 41.70548  1.000 16.63437 ? 47   ILE A CB  1 
ATOM   370  C CG1 . ILE A  1 48  ? -13.42631 -18.96748 42.63921  1.000 15.32437 ? 47   ILE A CG1 1 
ATOM   371  C CG2 . ILE A  1 48  ? -12.31278 -21.02144 41.71727  1.000 15.37941 ? 47   ILE A CG2 1 
ATOM   372  C CD1 . ILE A  1 48  ? -13.54181 -19.32908 44.15337  1.000 16.90539 ? 47   ILE A CD1 1 
ATOM   373  N N   . ASN A  1 49  ? -12.87229 -20.82512 38.37431  1.000 15.86903 ? 48   ASN A N   1 
ATOM   374  C CA  . ASN A  1 49  ? -12.68366 -21.94765 37.45036  1.000 16.03023 ? 48   ASN A CA  1 
ATOM   375  C C   . ASN A  1 49  ? -11.70303 -22.92898 38.07988  1.000 15.91690 ? 48   ASN A C   1 
ATOM   376  O O   . ASN A  1 49  ? -10.48497 -22.73947 38.00479  1.000 16.63551 ? 48   ASN A O   1 
ATOM   377  C CB  . ASN A  1 49  ? -12.16099 -21.48778 36.08915  1.000 15.98686 ? 48   ASN A CB  1 
ATOM   378  C CG  . ASN A  1 49  ? -13.20963 -20.78424 35.25580  1.000 17.66495 ? 48   ASN A CG  1 
ATOM   379  O OD1 . ASN A  1 49  ? -14.36810 -20.66843 35.65185  1.000 16.39944 ? 48   ASN A OD1 1 
ATOM   380  N ND2 . ASN A  1 49  ? -12.80002 -20.29966 34.08360  1.000 17.13129 ? 48   ASN A ND2 1 
ATOM   381  N N   . PHE A  1 50  ? -12.22672 -24.00496 38.65830  1.000 15.27997 ? 49   PHE A N   1 
ATOM   382  C CA  . PHE A  1 50  ? -11.36572 -25.08675 39.11957  1.000 17.11194 ? 49   PHE A CA  1 
ATOM   383  C C   . PHE A  1 50  ? -10.72412 -25.77257 37.92239  1.000 16.66572 ? 49   PHE A C   1 
ATOM   384  O O   . PHE A  1 50  ? -11.42177 -26.13589 36.97228  1.000 18.30707 ? 49   PHE A O   1 
ATOM   385  C CB  . PHE A  1 50  ? -12.16473 -26.10484 39.92703  1.000 18.44720 ? 49   PHE A CB  1 
ATOM   386  C CG  . PHE A  1 50  ? -11.32518 -27.24451 40.41854  1.000 19.73220 ? 49   PHE A CG  1 
ATOM   387  C CD1 . PHE A  1 50  ? -10.64487 -27.14471 41.62691  1.000 19.67771 ? 49   PHE A CD1 1 
ATOM   388  C CD2 . PHE A  1 50  ? -11.15872 -28.38846 39.64676  1.000 17.32033 ? 49   PHE A CD2 1 
ATOM   389  C CE1 . PHE A  1 50  ? -9.84855  -28.18450 42.07700  1.000 19.35280 ? 49   PHE A CE1 1 
ATOM   390  C CE2 . PHE A  1 50  ? -10.36643 -29.42683 40.08980  1.000 20.13189 ? 49   PHE A CE2 1 
ATOM   391  C CZ  . PHE A  1 50  ? -9.70026  -29.31927 41.31488  1.000 18.55124 ? 49   PHE A CZ  1 
ATOM   392  N N   . SER A  1 51  ? -9.40337  -25.98388 37.96825  1.000 15.91641 ? 50   SER A N   1 
ATOM   393  C CA  . SER A  1 51  ? -8.67028  -26.45743 36.79050  1.000 16.55320 ? 50   SER A CA  1 
ATOM   394  C C   . SER A  1 51  ? -7.54830  -27.40011 37.21693  1.000 17.72477 ? 50   SER A C   1 
ATOM   395  O O   . SER A  1 51  ? -6.96774  -27.21385 38.28767  1.000 17.78142 ? 50   SER A O   1 
ATOM   396  C CB  . SER A  1 51  ? -8.09287  -25.26804 36.01157  1.000 16.59657 ? 50   SER A CB  1 
ATOM   397  O OG  . SER A  1 51  ? -7.37519  -24.40116 36.89648  1.000 17.10873 ? 50   SER A OG  1 
ATOM   398  N N   . PHE A  1 52  ? -7.22663  -28.41781 36.39569  1.000 15.71848 ? 51   PHE A N   1 
ATOM   399  C CA  . PHE A  1 52  ? -7.87736  -28.78821 35.13038  1.000 15.63635 ? 51   PHE A CA  1 
ATOM   400  C C   . PHE A  1 52  ? -8.36489  -30.22820 35.18118  1.000 20.11870 ? 51   PHE A C   1 
ATOM   401  O O   . PHE A  1 52  ? -7.65373  -31.11307 35.67208  1.000 19.30456 ? 51   PHE A O   1 
ATOM   402  C CB  . PHE A  1 52  ? -6.90558  -28.68284 33.93755  1.000 18.03464 ? 51   PHE A CB  1 
ATOM   403  C CG  . PHE A  1 52  ? -6.70761  -27.29412 33.43018  1.000 17.95117 ? 51   PHE A CG  1 
ATOM   404  C CD1 . PHE A  1 52  ? -7.73051  -26.63293 32.76381  1.000 15.83812 ? 51   PHE A CD1 1 
ATOM   405  C CD2 . PHE A  1 52  ? -5.50071  -26.64556 33.61800  1.000 18.35228 ? 51   PHE A CD2 1 
ATOM   406  C CE1 . PHE A  1 52  ? -7.55823  -25.33549 32.29822  1.000 15.59905 ? 51   PHE A CE1 1 
ATOM   407  C CE2 . PHE A  1 52  ? -5.32238  -25.34153 33.15704  1.000 18.94360 ? 51   PHE A CE2 1 
ATOM   408  C CZ  . PHE A  1 52  ? -6.34937  -24.69553 32.48647  1.000 18.36389 ? 51   PHE A CZ  1 
ATOM   409  N N   . LEU A  1 53  ? -9.56085  -30.47912 34.65442  1.000 17.17819 ? 52   LEU A N   1 
ATOM   410  C CA  . LEU A  1 53  ? -9.94040  -31.83263 34.27573  1.000 17.35495 ? 52   LEU A CA  1 
ATOM   411  C C   . LEU A  1 53  ? -9.60203  -32.04489 32.79463  1.000 15.71541 ? 52   LEU A C   1 
ATOM   412  O O   . LEU A  1 53  ? -9.08852  -31.15542 32.11572  1.000 17.63196 ? 52   LEU A O   1 
ATOM   413  C CB  . LEU A  1 53  ? -11.41857 -32.07829 34.57749  1.000 15.21455 ? 52   LEU A CB  1 
ATOM   414  C CG  . LEU A  1 53  ? -11.69924 -32.51472 36.02356  1.000 18.55697 ? 52   LEU A CG  1 
ATOM   415  C CD1 . LEU A  1 53  ? -11.48987 -31.37889 37.01769  1.000 17.47102 ? 52   LEU A CD1 1 
ATOM   416  C CD2 . LEU A  1 53  ? -13.11635 -33.04716 36.13108  1.000 20.19714 ? 52   LEU A CD2 1 
ATOM   417  N N   . ASP A  1 54  ? -9.89489  -33.24063 32.28343  1.000 15.71984 ? 53   ASP A N   1 
ATOM   418  C CA  . ASP A  1 54  ? -9.41180  -33.67232 30.97568  1.000 17.06946 ? 53   ASP A CA  1 
ATOM   419  C C   . ASP A  1 54  ? -10.53407 -34.40626 30.25489  1.000 16.60652 ? 53   ASP A C   1 
ATOM   420  O O   . ASP A  1 54  ? -11.63462 -34.57749 30.79242  1.000 17.36980 ? 53   ASP A O   1 
ATOM   421  C CB  . ASP A  1 54  ? -8.18211  -34.57300 31.17061  1.000 19.33714 ? 53   ASP A CB  1 
ATOM   422  C CG  . ASP A  1 54  ? -7.31353  -34.70093 29.93462  1.000 20.38148 ? 53   ASP A CG  1 
ATOM   423  O OD1 . ASP A  1 54  ? -7.50855  -33.98334 28.91808  1.000 18.15106 ? 53   ASP A OD1 1 
ATOM   424  O OD2 . ASP A  1 54  ? -6.39935  -35.55226 30.00396  1.000 21.56109 ? 53   ASP A OD2 1 
ATOM   425  N N   . ILE A  1 55  ? -10.24963 -34.82755 29.02205  1.000 17.77110 ? 54   ILE A N   1 
ATOM   426  C CA  . ILE A  1 55  ? -11.03487 -35.83587 28.31742  1.000 18.94186 ? 54   ILE A CA  1 
ATOM   427  C C   . ILE A  1 55  ? -10.15969 -37.07651 28.18783  1.000 18.27785 ? 54   ILE A C   1 
ATOM   428  O O   . ILE A  1 55  ? -9.03360  -36.99152 27.68447  1.000 22.00565 ? 54   ILE A O   1 
ATOM   429  C CB  . ILE A  1 55  ? -11.49135 -35.34077 26.93344  1.000 17.44294 ? 54   ILE A CB  1 
ATOM   430  C CG1 . ILE A  1 55  ? -12.22286 -33.99532 27.05961  1.000 17.54806 ? 54   ILE A CG1 1 
ATOM   431  C CG2 . ILE A  1 55  ? -12.35288 -36.42912 26.23881  1.000 17.93793 ? 54   ILE A CG2 1 
ATOM   432  C CD1 . ILE A  1 55  ? -12.75212 -33.43453 25.75171  1.000 18.08937 ? 54   ILE A CD1 1 
ATOM   433  N N   . ASN A  1 56  ? -10.66400 -38.21870 28.64807  1.000 18.16626 ? 55   ASN A N   1 
ATOM   434  C CA  . ASN A  1 56  ? -9.86594  -39.43766 28.67062  1.000 19.82116 ? 55   ASN A CA  1 
ATOM   435  C C   . ASN A  1 56  ? -10.03957 -40.22407 27.37074  1.000 23.42175 ? 55   ASN A C   1 
ATOM   436  O O   . ASN A  1 56  ? -10.73740 -39.79813 26.44657  1.000 20.33284 ? 55   ASN A O   1 
ATOM   437  C CB  . ASN A  1 56  ? -10.21222 -40.28040 29.90204  1.000 21.96817 ? 55   ASN A CB  1 
ATOM   438  C CG  . ASN A  1 56  ? -11.64325 -40.82345 29.89063  1.000 21.21465 ? 55   ASN A CG  1 
ATOM   439  O OD1 . ASN A  1 56  ? -12.33877 -40.82246 28.86606  1.000 22.48155 ? 55   ASN A OD1 1 
ATOM   440  N ND2 . ASN A  1 56  ? -12.07991 -41.31349 31.04837  1.000 22.30462 ? 55   ASN A ND2 1 
ATOM   441  N N   . SER A  1 57  ? -9.38582  -41.39021 27.28867  1.000 20.97819 ? 56   SER A N   1 
ATOM   442  C CA  . SER A  1 57  ? -9.42952  -42.16043 26.04412  1.000 25.11223 ? 56   SER A CA  1 
ATOM   443  C C   . SER A  1 57  ? -10.80136 -42.77688 25.80424  1.000 21.13784 ? 56   SER A C   1 
ATOM   444  O O   . SER A  1 57  ? -11.09460 -43.19152 24.67545  1.000 25.04042 ? 56   SER A O   1 
ATOM   445  C CB  . SER A  1 57  ? -8.35693  -43.25311 26.05374  1.000 24.16022 ? 56   SER A CB  1 
ATOM   446  O OG  . SER A  1 57  ? -8.54002  -44.10316 27.16874  1.000 27.82286 ? 56   SER A OG  1 
ATOM   447  N N   . ASN A  1 58  ? -11.63823 -42.85507 26.83840  1.000 23.67549 ? 57   ASN A N   1 
ATOM   448  C CA  A ASN A  1 58  ? -13.04166 -43.21761 26.66728  0.593 23.40181 ? 57   ASN A CA  1 
ATOM   449  C CA  B ASN A  1 58  ? -13.04101 -43.21526 26.67487  0.407 23.43110 ? 57   ASN A CA  1 
ATOM   450  C C   . ASN A  1 58  ? -13.87951 -42.06002 26.14283  1.000 23.08640 ? 57   ASN A C   1 
ATOM   451  O O   . ASN A  1 58  ? -15.09690 -42.21913 25.98714  1.000 22.38171 ? 57   ASN A O   1 
ATOM   452  C CB  A ASN A  1 58  ? -13.63034 -43.72225 27.99079  0.593 24.14184 ? 57   ASN A CB  1 
ATOM   453  C CB  B ASN A  1 58  ? -13.61960 -43.70125 28.00635  0.407 24.15804 ? 57   ASN A CB  1 
ATOM   454  C CG  A ASN A  1 58  ? -14.87818 -44.57777 27.79200  0.593 25.21271 ? 57   ASN A CG  1 
ATOM   455  C CG  B ASN A  1 58  ? -13.09403 -45.06583 28.40958  0.407 25.62054 ? 57   ASN A CG  1 
ATOM   456  O OD1 A ASN A  1 58  ? -14.92666 -45.42410 26.90423  0.593 31.27163 ? 57   ASN A OD1 1 
ATOM   457  O OD1 B ASN A  1 58  ? -12.66046 -45.85254 27.56675  0.407 28.24050 ? 57   ASN A OD1 1 
ATOM   458  N ND2 A ASN A  1 58  ? -15.89231 -44.35271 28.62070  0.593 28.49613 ? 57   ASN A ND2 1 
ATOM   459  N ND2 B ASN A  1 58  ? -13.13693 -45.35568 29.70452  0.407 29.66123 ? 57   ASN A ND2 1 
ATOM   460  N N   . LEU A  1 59  ? -13.25682 -40.91141 25.87393  1.000 19.93651 ? 58   LEU A N   1 
ATOM   461  C CA  . LEU A  1 59  ? -13.92011 -39.74033 25.28652  1.000 17.41444 ? 58   LEU A CA  1 
ATOM   462  C C   . LEU A  1 59  ? -14.97785 -39.18040 26.23484  1.000 19.85182 ? 58   LEU A C   1 
ATOM   463  O O   . LEU A  1 59  ? -16.03888 -38.69766 25.82541  1.000 21.76149 ? 58   LEU A O   1 
ATOM   464  C CB  . LEU A  1 59  ? -14.49453 -40.05955 23.90136  1.000 17.86973 ? 58   LEU A CB  1 
ATOM   465  C CG  . LEU A  1 59  ? -13.48735 -40.73002 22.95539  1.000 19.18754 ? 58   LEU A CG  1 
ATOM   466  C CD1 . LEU A  1 59  ? -14.06036 -40.88202 21.52337  1.000 18.93165 ? 58   LEU A CD1 1 
ATOM   467  C CD2 . LEU A  1 59  ? -12.16404 -39.94397 22.91436  1.000 20.36119 ? 58   LEU A CD2 1 
ATOM   468  N N   . GLU A  1 60  ? -14.66139 -39.21266 27.52220  1.000 17.48082 ? 59   GLU A N   1 
ATOM   469  C CA  . GLU A  1 60  ? -15.49924 -38.62565 28.54769  1.000 18.86425 ? 59   GLU A CA  1 
ATOM   470  C C   . GLU A  1 60  ? -14.69622 -37.62828 29.36198  1.000 21.06273 ? 59   GLU A C   1 
ATOM   471  O O   . GLU A  1 60  ? -13.47762 -37.75258 29.51657  1.000 20.85834 ? 59   GLU A O   1 
ATOM   472  C CB  . GLU A  1 60  ? -16.06671 -39.69992 29.49231  1.000 18.41841 ? 59   GLU A CB  1 
ATOM   473  C CG  . GLU A  1 60  ? -17.09231 -40.60524 28.81042  1.000 21.81841 ? 59   GLU A CG  1 
ATOM   474  C CD  . GLU A  1 60  ? -17.68923 -41.62159 29.76173  1.000 34.12015 ? 59   GLU A CD  1 
ATOM   475  O OE1 . GLU A  1 60  ? -16.90898 -42.34584 30.40498  1.000 35.60844 ? 59   GLU A OE1 1 
ATOM   476  O OE2 . GLU A  1 60  ? -18.93100 -41.69566 29.86666  1.000 29.99398 ? 59   GLU A OE2 1 
ATOM   477  N N   A CYS A  1 61  ? -15.37770 -36.59594 29.83555  0.828 19.12929 ? 60   CYS A N   1 
ATOM   478  N N   B CYS A  1 61  ? -15.42379 -36.66162 29.91308  0.172 19.23414 ? 60   CYS A N   1 
ATOM   479  C CA  A CYS A  1 61  ? -14.78336 -35.72808 30.83613  0.828 19.56455 ? 60   CYS A CA  1 
ATOM   480  C CA  B CYS A  1 61  ? -14.90003 -35.75610 30.92432  0.172 19.73491 ? 60   CYS A CA  1 
ATOM   481  C C   A CYS A  1 61  ? -14.33849 -36.56289 32.02943  0.828 20.15631 ? 60   CYS A C   1 
ATOM   482  C C   B CYS A  1 61  ? -14.38072 -36.54586 32.12131  0.172 20.23544 ? 60   CYS A C   1 
ATOM   483  O O   A CYS A  1 61  ? -15.07719 -37.43064 32.50482  0.828 19.38657 ? 60   CYS A O   1 
ATOM   484  O O   B CYS A  1 61  ? -15.10790 -37.36269 32.69363  0.172 19.70690 ? 60   CYS A O   1 
ATOM   485  C CB  A CYS A  1 61  ? -15.80460 -34.68171 31.26106  0.828 19.63217 ? 60   CYS A CB  1 
ATOM   486  C CB  B CYS A  1 61  ? -16.02383 -34.81355 31.35491  0.172 19.46532 ? 60   CYS A CB  1 
ATOM   487  S SG  A CYS A  1 61  ? -15.27748 -33.69168 32.62998  0.828 23.15723 ? 60   CYS A SG  1 
ATOM   488  S SG  B CYS A  1 61  ? -16.10404 -33.30299 30.38617  0.172 22.34210 ? 60   CYS A SG  1 
ATOM   489  N N   . ALA A  1 62  ? -13.12820 -36.30490 32.51836  1.000 20.48980 ? 61   ALA A N   1 
ATOM   490  C CA  . ALA A  1 62  ? -12.57955 -37.11168 33.60353  1.000 21.86140 ? 61   ALA A CA  1 
ATOM   491  C C   . ALA A  1 62  ? -11.47963 -36.36868 34.34425  1.000 19.29503 ? 61   ALA A C   1 
ATOM   492  O O   . ALA A  1 62  ? -10.77189 -35.53984 33.77168  1.000 20.97982 ? 61   ALA A O   1 
ATOM   493  C CB  . ALA A  1 62  ? -12.02859 -38.44479 33.07356  1.000 23.46405 ? 61   ALA A CB  1 
ATOM   494  N N   . TRP A  1 63  ? -11.33535 -36.69976 35.62372  1.000 17.72980 ? 62   TRP A N   1 
ATOM   495  C CA  . TRP A  1 63  ? -10.13814 -36.33564 36.36308  1.000 18.80123 ? 62   TRP A CA  1 
ATOM   496  C C   . TRP A  1 63  ? -8.93300  -37.09550 35.82777  1.000 23.15154 ? 62   TRP A C   1 
ATOM   497  O O   . TRP A  1 63  ? -9.06209  -38.20201 35.30566  1.000 22.98842 ? 62   TRP A O   1 
ATOM   498  C CB  . TRP A  1 63  ? -10.30664 -36.67552 37.84537  1.000 17.92270 ? 62   TRP A CB  1 
ATOM   499  C CG  . TRP A  1 63  ? -11.36950 -35.89952 38.54416  1.000 20.55062 ? 62   TRP A CG  1 
ATOM   500  C CD1 . TRP A  1 63  ? -12.70519 -36.17091 38.57466  1.000 17.57016 ? 62   TRP A CD1 1 
ATOM   501  C CD2 . TRP A  1 63  ? -11.18089 -34.72009 39.32369  1.000 18.81615 ? 62   TRP A CD2 1 
ATOM   502  N NE1 . TRP A  1 63  ? -13.36110 -35.22818 39.32716  1.000 19.02158 ? 62   TRP A NE1 1 
ATOM   503  C CE2 . TRP A  1 63  ? -12.44703 -34.32645 39.80023  1.000 18.16946 ? 62   TRP A CE2 1 
ATOM   504  C CE3 . TRP A  1 63  ? -10.06023 -33.96188 39.67464  1.000 19.98921 ? 62   TRP A CE3 1 
ATOM   505  C CZ2 . TRP A  1 63  ? -12.62879 -33.20484 40.60897  1.000 18.80803 ? 62   TRP A CZ2 1 
ATOM   506  C CZ3 . TRP A  1 63  ? -10.24379 -32.84766 40.48830  1.000 18.32169 ? 62   TRP A CZ3 1 
ATOM   507  C CH2 . TRP A  1 63  ? -11.51760 -32.47863 40.93779  1.000 17.39771 ? 62   TRP A CH2 1 
ATOM   508  N N   . ASP A  1 64  ? -7.74825  -36.49145 35.96729  1.000 20.40448 ? 63   ASP A N   1 
ATOM   509  C CA  . ASP A  1 64  ? -6.48233  -37.20835 35.81681  1.000 21.68009 ? 63   ASP A CA  1 
ATOM   510  C C   . ASP A  1 64  ? -6.62398  -38.52952 36.57662  1.000 19.45739 ? 63   ASP A C   1 
ATOM   511  O O   . ASP A  1 64  ? -7.02281  -38.52856 37.74332  1.000 21.74581 ? 63   ASP A O   1 
ATOM   512  C CB  . ASP A  1 64  ? -5.33353  -36.32925 36.34567  1.000 23.97093 ? 63   ASP A CB  1 
ATOM   513  C CG  . ASP A  1 64  ? -3.98022  -37.04851 36.43932  1.000 29.43814 ? 63   ASP A CG  1 
ATOM   514  O OD1 . ASP A  1 64  ? -3.87484  -38.26042 36.17942  1.000 28.10801 ? 63   ASP A OD1 1 
ATOM   515  O OD2 . ASP A  1 64  ? -2.98789  -36.36830 36.78991  1.000 27.73281 ? 63   ASP A OD2 1 
ATOM   516  N N   . PRO A  1 65  ? -6.36832  -39.67581 35.93481  1.000 22.40103 ? 64   PRO A N   1 
ATOM   517  C CA  . PRO A  1 65  ? -6.60861  -40.96265 36.61100  1.000 25.15630 ? 64   PRO A CA  1 
ATOM   518  C C   . PRO A  1 65  ? -5.71372  -41.19454 37.81754  1.000 28.30077 ? 64   PRO A C   1 
ATOM   519  O O   . PRO A  1 65  ? -6.02544  -42.06674 38.64013  1.000 29.51632 ? 64   PRO A O   1 
ATOM   520  C CB  . PRO A  1 65  ? -6.34515  -41.99896 35.50551  1.000 24.99792 ? 64   PRO A CB  1 
ATOM   521  C CG  . PRO A  1 65  ? -5.51336  -41.29333 34.49932  1.000 29.80703 ? 64   PRO A CG  1 
ATOM   522  C CD  . PRO A  1 65  ? -5.92644  -39.85204 34.54296  1.000 24.69136 ? 64   PRO A CD  1 
ATOM   523  N N   . ALA A  1 66  ? -4.62735  -40.43982 37.96035  1.000 24.59731 ? 65   ALA A N   1 
ATOM   524  C CA  . ALA A  1 66  ? -3.78781  -40.52126 39.15471  1.000 26.55156 ? 65   ALA A CA  1 
ATOM   525  C C   . ALA A  1 66  ? -4.38074  -39.79090 40.35247  1.000 28.72112 ? 65   ALA A C   1 
ATOM   526  O O   . ALA A  1 66  ? -3.80478  -39.85531 41.45069  1.000 25.65984 ? 65   ALA A O   1 
ATOM   527  C CB  . ALA A  1 66  ? -2.39527  -39.96538 38.84608  1.000 26.74280 ? 65   ALA A CB  1 
ATOM   528  N N   . THR A  1 67  ? -5.51490  -39.11565 40.17622  1.000 24.36770 ? 66   THR A N   1 
ATOM   529  C CA  . THR A  1 67  ? -6.11455  -38.33213 41.24920  1.000 22.09833 ? 66   THR A CA  1 
ATOM   530  C C   . THR A  1 67  ? -6.69545  -39.23534 42.32171  1.000 25.74533 ? 66   THR A C   1 
ATOM   531  O O   . THR A  1 67  ? -7.44094  -40.17487 42.02276  1.000 26.27194 ? 66   THR A O   1 
ATOM   532  C CB  . THR A  1 67  ? -7.23377  -37.43917 40.70886  1.000 23.96593 ? 66   THR A CB  1 
ATOM   533  O OG1 . THR A  1 67  ? -6.74692  -36.66663 39.60849  1.000 20.76689 ? 66   THR A OG1 1 
ATOM   534  C CG2 . THR A  1 67  ? -7.73523  -36.50598 41.79818  1.000 24.72291 ? 66   THR A CG2 1 
ATOM   535  N N   . ASN A  1 68  ? -6.37900  -38.92813 43.57443  1.000 24.99923 ? 67   ASN A N   1 
ATOM   536  C CA  . ASN A  1 68  ? -7.08173  -39.52670 44.69755  1.000 23.42176 ? 67   ASN A CA  1 
ATOM   537  C C   . ASN A  1 68  ? -8.46708  -38.89999 44.77905  1.000 24.17119 ? 67   ASN A C   1 
ATOM   538  O O   . ASN A  1 68  ? -8.59690  -37.70928 45.08081  1.000 24.77996 ? 67   ASN A O   1 
ATOM   539  C CB  . ASN A  1 68  ? -6.29622  -39.30677 45.98903  1.000 25.85045 ? 67   ASN A CB  1 
ATOM   540  C CG  . ASN A  1 68  ? -6.94298  -39.97563 47.18651  1.000 31.45950 ? 67   ASN A CG  1 
ATOM   541  O OD1 . ASN A  1 68  ? -8.04524  -39.62056 47.60229  1.000 28.84948 ? 67   ASN A OD1 1 
ATOM   542  N ND2 . ASN A  1 68  ? -6.24871  -40.95032 47.75406  1.000 47.82888 ? 67   ASN A ND2 1 
ATOM   543  N N   . ASP A  1 69  ? -9.50800  -39.69544 44.52059  1.000 23.92161 ? 68   ASP A N   1 
ATOM   544  C CA  . ASP A  1 69  ? -10.84965 -39.12545 44.40223  1.000 25.75132 ? 68   ASP A CA  1 
ATOM   545  C C   . ASP A  1 69  ? -11.33215 -38.52923 45.71977  1.000 25.60971 ? 68   ASP A C   1 
ATOM   546  O O   . ASP A  1 69  ? -11.96045 -37.46658 45.72958  1.000 23.45858 ? 68   ASP A O   1 
ATOM   547  C CB  . ASP A  1 69  ? -11.84127 -40.17909 43.90443  1.000 24.52161 ? 68   ASP A CB  1 
ATOM   548  C CG  . ASP A  1 69  ? -13.18338 -39.57744 43.53433  1.000 30.01433 ? 68   ASP A CG  1 
ATOM   549  O OD1 . ASP A  1 69  ? -13.22531 -38.72633 42.61586  1.000 25.96479 ? 68   ASP A OD1 1 
ATOM   550  O OD2 . ASP A  1 69  ? -14.19073 -39.92841 44.17458  1.000 27.96606 ? 68   ASP A OD2 1 
ATOM   551  N N   . ALA A  1 70  ? -11.07717 -39.20155 46.84584  1.000 24.30412 ? 69   ALA A N   1 
ATOM   552  C CA  . ALA A  1 70  ? -11.51301 -38.64123 48.12043  1.000 26.49048 ? 69   ALA A CA  1 
ATOM   553  C C   . ALA A  1 70  ? -10.88302 -37.27461 48.35873  1.000 19.67979 ? 69   ALA A C   1 
ATOM   554  O O   . ALA A  1 70  ? -11.55555 -36.34473 48.82161  1.000 23.99280 ? 69   ALA A O   1 
ATOM   555  C CB  . ALA A  1 70  ? -11.17391 -39.59583 49.26751  1.000 29.48549 ? 69   ALA A CB  1 
ATOM   556  N N   A LYS A  1 71  ? -9.59583  -37.12279 48.03705  0.552 22.32248 ? 70   LYS A N   1 
ATOM   557  N N   B LYS A  1 71  ? -9.58635  -37.14952 48.06619  0.448 22.37236 ? 70   LYS A N   1 
ATOM   558  C CA  A LYS A  1 71  ? -8.94495  -35.83175 48.24801  0.552 24.34624 ? 70   LYS A CA  1 
ATOM   559  C CA  B LYS A  1 71  ? -8.90637  -35.86718 48.20102  0.448 24.38442 ? 70   LYS A CA  1 
ATOM   560  C C   A LYS A  1 71  ? -9.42014  -34.78974 47.23973  0.552 23.78725 ? 70   LYS A C   1 
ATOM   561  C C   B LYS A  1 71  ? -9.52850  -34.83144 47.27710  0.448 23.85332 ? 70   LYS A C   1 
ATOM   562  O O   A LYS A  1 71  ? -9.49784  -33.60251 47.57376  0.552 22.19855 ? 70   LYS A O   1 
ATOM   563  O O   B LYS A  1 71  ? -9.82520  -33.70510 47.69536  0.448 21.27662 ? 70   LYS A O   1 
ATOM   564  C CB  A LYS A  1 71  ? -7.42533  -35.98814 48.18247  0.552 24.12321 ? 70   LYS A CB  1 
ATOM   565  C CB  B LYS A  1 71  ? -7.41935  -36.03162 47.88708  0.448 23.55327 ? 70   LYS A CB  1 
ATOM   566  C CG  A LYS A  1 71  ? -6.85200  -36.96193 49.22276  0.552 26.26339 ? 70   LYS A CG  1 
ATOM   567  C CG  B LYS A  1 71  ? -6.61054  -36.74752 48.96230  0.448 27.50372 ? 70   LYS A CG  1 
ATOM   568  C CD  A LYS A  1 71  ? -5.62681  -36.39949 49.94266  0.552 33.15931 ? 70   LYS A CD  1 
ATOM   569  C CD  B LYS A  1 71  ? -6.37164  -35.84401 50.15315  0.448 29.53321 ? 70   LYS A CD  1 
ATOM   570  C CE  A LYS A  1 71  ? -5.98735  -35.22571 50.85189  0.552 37.05083 ? 70   LYS A CE  1 
ATOM   571  C CE  B LYS A  1 71  ? -6.31852  -36.64361 51.44073  0.448 38.32430 ? 70   LYS A CE  1 
ATOM   572  N NZ  A LYS A  1 71  ? -4.94159  -34.94140 51.89115  0.552 30.25809 ? 70   LYS A NZ  1 
ATOM   573  N NZ  B LYS A  1 71  ? -5.03739  -37.38734 51.52462  0.448 31.67077 ? 70   LYS A NZ  1 
ATOM   574  N N   . ALA A  1 72  ? -9.74496  -35.20956 46.01401  1.000 22.24351 ? 71   ALA A N   1 
ATOM   575  C CA  . ALA A  1 72  ? -10.32281 -34.28230 45.04263  1.000 21.03734 ? 71   ALA A CA  1 
ATOM   576  C C   . ALA A  1 72  ? -11.65994 -33.74513 45.53120  1.000 20.65836 ? 71   ALA A C   1 
ATOM   577  O O   . ALA A  1 72  ? -11.92152 -32.53901 45.45739  1.000 21.21234 ? 71   ALA A O   1 
ATOM   578  C CB  . ALA A  1 72  ? -10.47857 -34.97372 43.68321  1.000 20.87569 ? 71   ALA A CB  1 
ATOM   579  N N   . ARG A  1 73  ? -12.52175 -34.62837 46.04784  1.000 21.45145 ? 72   ARG A N   1 
ATOM   580  C CA  . ARG A  1 73  ? -13.82130 -34.17589 46.53035  1.000 19.78994 ? 72   ARG A CA  1 
ATOM   581  C C   . ARG A  1 73  ? -13.66825 -33.23169 47.70551  1.000 20.64159 ? 72   ARG A C   1 
ATOM   582  O O   . ARG A  1 73  ? -14.42804 -32.26537 47.83558  1.000 23.52193 ? 72   ARG A O   1 
ATOM   583  C CB  . ARG A  1 73  ? -14.69652 -35.36949 46.91616  1.000 22.34764 ? 72   ARG A CB  1 
ATOM   584  C CG  . ARG A  1 73  ? -15.10372 -36.20859 45.70752  1.000 23.47683 ? 72   ARG A CG  1 
ATOM   585  C CD  . ARG A  1 73  ? -15.94510 -37.41915 46.11874  1.000 25.86640 ? 72   ARG A CD  1 
ATOM   586  N NE  . ARG A  1 73  ? -16.21228 -38.26950 44.96358  1.000 25.18884 ? 72   ARG A NE  1 
ATOM   587  C CZ  . ARG A  1 73  ? -17.24945 -38.12705 44.15161  1.000 25.41995 ? 72   ARG A CZ  1 
ATOM   588  N NH1 . ARG A  1 73  ? -18.15771 -37.18517 44.34876  1.000 21.83872 ? 72   ARG A NH1 1 
ATOM   589  N NH2 . ARG A  1 73  ? -17.38167 -38.95692 43.11940  1.000 23.46978 ? 72   ARG A NH2 1 
ATOM   590  N N   . ASP A  1 74  ? -12.70011 -33.50389 48.58315  1.000 23.99390 ? 73   ASP A N   1 
ATOM   591  C CA  . ASP A  1 74  ? -12.47229 -32.61572 49.71594  1.000 23.37278 ? 73   ASP A CA  1 
ATOM   592  C C   . ASP A  1 74  ? -12.07885 -31.22219 49.24251  1.000 24.40967 ? 73   ASP A C   1 
ATOM   593  O O   . ASP A  1 74  ? -12.56557 -30.21654 49.77028  1.000 23.13146 ? 73   ASP A O   1 
ATOM   594  C CB  . ASP A  1 74  ? -11.39194 -33.19432 50.62744  1.000 24.63770 ? 73   ASP A CB  1 
ATOM   595  C CG  . ASP A  1 74  ? -11.07258 -32.27679 51.79531  1.000 30.40686 ? 73   ASP A CG  1 
ATOM   596  O OD1 . ASP A  1 74  ? -11.95101 -32.10349 52.66371  1.000 40.54521 ? 73   ASP A OD1 1 
ATOM   597  O OD2 . ASP A  1 74  ? -9.96069  -31.71271 51.82823  1.000 35.07049 ? 73   ASP A OD2 1 
ATOM   598  N N   . VAL A  1 75  ? -11.21813 -31.14149 48.22730  1.000 21.08903 ? 74   VAL A N   1 
ATOM   599  C CA  . VAL A  1 75  ? -10.78520 -29.83709 47.73460  1.000 20.19058 ? 74   VAL A CA  1 
ATOM   600  C C   . VAL A  1 75  ? -11.95409 -29.09779 47.09446  1.000 19.95679 ? 74   VAL A C   1 
ATOM   601  O O   . VAL A  1 75  ? -12.19550 -27.91783 47.37516  1.000 18.38335 ? 74   VAL A O   1 
ATOM   602  C CB  . VAL A  1 75  ? -9.60861  -30.00195 46.75626  1.000 21.61131 ? 74   VAL A CB  1 
ATOM   603  C CG1 . VAL A  1 75  ? -9.26848  -28.66221 46.09032  1.000 20.58763 ? 74   VAL A CG1 1 
ATOM   604  C CG2 . VAL A  1 75  ? -8.39442  -30.57365 47.49978  1.000 22.70023 ? 74   VAL A CG2 1 
ATOM   605  N N   . VAL A  1 76  ? -12.70538 -29.77980 46.22544  1.000 19.41613 ? 75   VAL A N   1 
ATOM   606  C CA  . VAL A  1 76  ? -13.85294 -29.13165 45.59316  1.000 18.57141 ? 75   VAL A CA  1 
ATOM   607  C C   . VAL A  1 76  ? -14.87534 -28.71256 46.64113  1.000 20.70011 ? 75   VAL A C   1 
ATOM   608  O O   . VAL A  1 76  ? -15.47311 -27.63355 46.55188  1.000 19.49720 ? 75   VAL A O   1 
ATOM   609  C CB  . VAL A  1 76  ? -14.47622 -30.06504 44.53528  1.000 17.46330 ? 75   VAL A CB  1 
ATOM   610  C CG1 . VAL A  1 76  ? -15.75093 -29.45302 43.97495  1.000 18.86218 ? 75   VAL A CG1 1 
ATOM   611  C CG2 . VAL A  1 76  ? -13.46254 -30.35941 43.43930  1.000 19.53914 ? 75   VAL A CG2 1 
ATOM   612  N N   . ASN A  1 77  ? -15.08520 -29.55139 47.65910  1.000 19.98491 ? 76   ASN A N   1 
ATOM   613  C CA  . ASN A  1 77  ? -16.03107 -29.21208 48.71790  1.000 24.29785 ? 76   ASN A CA  1 
ATOM   614  C C   . ASN A  1 77  ? -15.61664 -27.93900 49.45268  1.000 18.96827 ? 76   ASN A C   1 
ATOM   615  O O   . ASN A  1 77  ? -16.46852 -27.12462 49.82844  1.000 20.07582 ? 76   ASN A O   1 
ATOM   616  C CB  . ASN A  1 77  ? -16.15454 -30.38034 49.70253  1.000 20.25129 ? 76   ASN A CB  1 
ATOM   617  C CG  . ASN A  1 77  ? -16.94193 -31.54390 49.13197  1.000 23.88707 ? 76   ASN A CG  1 
ATOM   618  O OD1 . ASN A  1 77  ? -17.57998 -31.42977 48.08128  1.000 25.47523 ? 76   ASN A OD1 1 
ATOM   619  N ND2 . ASN A  1 77  ? -16.88953 -32.68312 49.81929  1.000 23.72634 ? 76   ASN A ND2 1 
ATOM   620  N N   . ARG A  1 78  ? -14.31422 -27.74226 49.65932  1.000 19.27465 ? 77   ARG A N   1 
ATOM   621  C CA  . ARG A  1 78  ? -13.86530 -26.50080 50.28563  1.000 20.08143 ? 77   ARG A CA  1 
ATOM   622  C C   . ARG A  1 78  ? -14.17849 -25.29842 49.40890  1.000 20.15984 ? 77   ARG A C   1 
ATOM   623  O O   . ARG A  1 78  ? -14.55047 -24.23261 49.91422  1.000 18.47739 ? 77   ARG A O   1 
ATOM   624  C CB  . ARG A  1 78  ? -12.37437 -26.56937 50.58753  1.000 19.71106 ? 77   ARG A CB  1 
ATOM   625  C CG  . ARG A  1 78  ? -12.04536 -27.59677 51.66495  1.000 23.62534 ? 77   ARG A CG  1 
ATOM   626  C CD  . ARG A  1 78  ? -10.56104 -27.85124 51.73966  1.000 24.57025 ? 77   ARG A CD  1 
ATOM   627  N NE  . ARG A  1 78  ? -10.28691 -29.00249 52.58633  1.000 27.55967 ? 77   ARG A NE  1 
ATOM   628  C CZ  . ARG A  1 78  ? -10.06101 -28.91804 53.88882  1.000 33.72005 ? 77   ARG A CZ  1 
ATOM   629  N NH1 . ARG A  1 78  ? -10.05751 -27.75145 54.51104  1.000 30.46459 ? 77   ARG A NH1 1 
ATOM   630  N NH2 . ARG A  1 78  ? -9.84195  -30.03115 54.58246  1.000 36.10377 ? 77   ARG A NH2 1 
ATOM   631  N N   . LEU A  1 79  ? -14.03386 -25.44712 48.08556  1.000 17.82697 ? 78   LEU A N   1 
ATOM   632  C CA  . LEU A  1 79  ? -14.38577 -24.34692 47.19604  1.000 16.90038 ? 78   LEU A CA  1 
ATOM   633  C C   . LEU A  1 79  ? -15.88594 -24.07398 47.21300  1.000 16.54443 ? 78   LEU A C   1 
ATOM   634  O O   . LEU A  1 79  ? -16.31234 -22.91613 47.28774  1.000 17.47331 ? 78   LEU A O   1 
ATOM   635  C CB  . LEU A  1 79  ? -13.91844 -24.64819 45.76351  1.000 16.96776 ? 78   LEU A CB  1 
ATOM   636  C CG  . LEU A  1 79  ? -12.41165 -24.55720 45.57062  1.000 17.55153 ? 78   LEU A CG  1 
ATOM   637  C CD1 . LEU A  1 79  ? -11.99018 -25.29314 44.28567  1.000 17.32618 ? 78   LEU A CD1 1 
ATOM   638  C CD2 . LEU A  1 79  ? -11.96666 -23.10119 45.52544  1.000 18.27512 ? 78   LEU A CD2 1 
ATOM   639  N N   . THR A  1 80  ? -16.71538 -25.11600 47.10379  1.000 19.29493 ? 79   THR A N   1 
ATOM   640  C CA  . THR A  1 80  ? -18.14256 -24.82263 47.03642  1.000 17.52397 ? 79   THR A CA  1 
ATOM   641  C C   . THR A  1 80  ? -18.67385 -24.32369 48.37805  1.000 20.01728 ? 79   THR A C   1 
ATOM   642  O O   . THR A  1 80  ? -19.68644 -23.60886 48.40355  1.000 19.92286 ? 79   THR A O   1 
ATOM   643  C CB  . THR A  1 80  ? -18.93419 -26.04091 46.54620  1.000 20.94786 ? 79   THR A CB  1 
ATOM   644  O OG1 . THR A  1 80  ? -18.73758 -27.14761 47.42800  1.000 24.72244 ? 79   THR A OG1 1 
ATOM   645  C CG2 . THR A  1 80  ? -18.46438 -26.42763 45.14560  1.000 19.74481 ? 79   THR A CG2 1 
ATOM   646  N N   . ALA A  1 81  ? -17.96986 -24.61997 49.47067  1.000 22.19828 ? 80   ALA A N   1 
ATOM   647  C CA  . ALA A  1 81  ? -18.32921 -24.04555 50.76542  1.000 22.06591 ? 80   ALA A CA  1 
ATOM   648  C C   . ALA A  1 81  ? -18.23204 -22.52716 50.75730  1.000 23.82539 ? 80   ALA A C   1 
ATOM   649  O O   . ALA A  1 81  ? -18.93195 -21.85663 51.53014  1.000 24.03941 ? 80   ALA A O   1 
ATOM   650  C CB  . ALA A  1 81  ? -17.43431 -24.62146 51.86147  1.000 20.47294 ? 80   ALA A CB  1 
ATOM   651  N N   . LEU A  1 82  ? -17.38085 -21.96164 49.89179  1.000 21.67201 ? 81   LEU A N   1 
ATOM   652  C CA  . LEU A  1 82  ? -17.24659 -20.51192 49.80739  1.000 19.61812 ? 81   LEU A CA  1 
ATOM   653  C C   . LEU A  1 82  ? -18.52734 -19.83975 49.35786  1.000 21.25729 ? 81   LEU A C   1 
ATOM   654  O O   . LEU A  1 82  ? -18.69609 -18.63695 49.59004  1.000 22.17420 ? 81   LEU A O   1 
ATOM   655  C CB  . LEU A  1 82  ? -16.12023 -20.13438 48.84165  1.000 18.51945 ? 81   LEU A CB  1 
ATOM   656  C CG  . LEU A  1 82  ? -14.72700 -20.66499 49.16780  1.000 18.25084 ? 81   LEU A CG  1 
ATOM   657  C CD1 . LEU A  1 82  ? -13.77027 -20.36802 48.00840  1.000 19.66406 ? 81   LEU A CD1 1 
ATOM   658  C CD2 . LEU A  1 82  ? -14.21253 -20.05389 50.47079  1.000 22.42720 ? 81   LEU A CD2 1 
ATOM   659  N N   A LYS A  1 83  ? -19.42993 -20.57929 48.70807  0.622 19.75110 ? 82   LYS A N   1 
ATOM   660  N N   B LYS A  1 83  ? -19.43252 -20.57765 48.71141  0.378 19.83022 ? 82   LYS A N   1 
ATOM   661  C CA  A LYS A  1 83  ? -20.67840 -19.98269 48.25383  0.622 21.01983 ? 82   LYS A CA  1 
ATOM   662  C CA  B LYS A  1 83  ? -20.67932 -19.97923 48.25260  0.378 21.09547 ? 82   LYS A CA  1 
ATOM   663  C C   A LYS A  1 83  ? -21.51388 -19.47710 49.41747  0.622 24.35031 ? 82   LYS A C   1 
ATOM   664  C C   B LYS A  1 83  ? -21.54660 -19.51469 49.41179  0.378 24.35196 ? 82   LYS A C   1 
ATOM   665  O O   A LYS A  1 83  ? -22.39023 -18.63054 49.21529  0.622 24.71853 ? 82   LYS A O   1 
ATOM   666  O O   B LYS A  1 83  ? -22.48722 -18.74231 49.19920  0.378 24.91039 ? 82   LYS A O   1 
ATOM   667  C CB  A LYS A  1 83  ? -21.46934 -20.99110 47.42128  0.622 21.13376 ? 82   LYS A CB  1 
ATOM   668  C CB  B LYS A  1 83  ? -21.43927 -20.97161 47.37575  0.378 21.21617 ? 82   LYS A CB  1 
ATOM   669  C CG  A LYS A  1 83  ? -20.80203 -21.28869 46.07813  0.622 19.75610 ? 82   LYS A CG  1 
ATOM   670  C CG  B LYS A  1 83  ? -20.69602 -21.30255 46.08723  0.378 19.69492 ? 82   LYS A CG  1 
ATOM   671  C CD  A LYS A  1 83  ? -21.70574 -22.10837 45.16867  0.622 19.52995 ? 82   LYS A CD  1 
ATOM   672  C CD  B LYS A  1 83  ? -21.21328 -22.58336 45.46318  0.378 20.50293 ? 82   LYS A CD  1 
ATOM   673  C CE  A LYS A  1 83  ? -21.58519 -23.59389 45.48100  0.622 16.30982 ? 82   LYS A CE  1 
ATOM   674  C CE  B LYS A  1 83  ? -22.57260 -22.36358 44.82882  0.378 19.87485 ? 82   LYS A CE  1 
ATOM   675  N NZ  A LYS A  1 83  ? -22.59824 -24.40446 44.73539  0.622 22.45883 ? 82   LYS A NZ  1 
ATOM   676  N NZ  B LYS A  1 83  ? -23.12384 -23.64119 44.30116  0.378 21.63343 ? 82   LYS A NZ  1 
ATOM   677  N N   . ALA A  1 84  ? -21.24544 -19.96429 50.63164  1.000 23.36038 ? 83   ALA A N   1 
ATOM   678  C CA  . ALA A  1 84  ? -21.94897 -19.45089 51.80205  1.000 29.46170 ? 83   ALA A CA  1 
ATOM   679  C C   . ALA A  1 84  ? -21.69179 -17.96088 51.99181  1.000 28.66498 ? 83   ALA A C   1 
ATOM   680  O O   . ALA A  1 84  ? -22.53870 -17.24633 52.54268  1.000 29.69380 ? 83   ALA A O   1 
ATOM   681  C CB  . ALA A  1 84  ? -21.52272 -20.23771 53.04191  1.000 29.89808 ? 83   ALA A CB  1 
ATOM   682  N N   . HIS A  1 85  ? -20.54814 -17.46328 51.51673  1.000 27.30272 ? 84   HIS A N   1 
ATOM   683  C CA  . HIS A  1 85  ? -20.21849 -16.05080 51.65755  1.000 31.73126 ? 84   HIS A CA  1 
ATOM   684  C C   . HIS A  1 85  ? -20.65736 -15.20688 50.46844  1.000 33.44198 ? 84   HIS A C   1 
ATOM   685  O O   . HIS A  1 85  ? -20.58826 -13.97647 50.54433  1.000 28.26763 ? 84   HIS A O   1 
ATOM   686  C CB  . HIS A  1 85  ? -18.70756 -15.88167 51.87848  1.000 33.07876 ? 84   HIS A CB  1 
ATOM   687  C CG  . HIS A  1 85  ? -18.15765 -16.75279 52.96840  1.000 42.76748 ? 84   HIS A CG  1 
ATOM   688  N ND1 . HIS A  1 85  ? -18.50336 -16.59603 54.29372  1.000 45.68978 ? 84   HIS A ND1 1 
ATOM   689  C CD2 . HIS A  1 85  ? -17.28435 -17.78769 52.92977  1.000 38.12132 ? 84   HIS A CD2 1 
ATOM   690  C CE1 . HIS A  1 85  ? -17.87418 -17.50002 55.02390  1.000 45.25466 ? 84   HIS A CE1 1 
ATOM   691  N NE2 . HIS A  1 85  ? -17.12710 -18.23532 54.21989  1.000 51.97236 ? 84   HIS A NE2 1 
ATOM   692  N N   . ASN A  1 86  ? -21.11831 -15.82442 49.37679  1.000 24.06602 ? 85   ASN A N   1 
ATOM   693  C CA  . ASN A  1 86  ? -21.45192 -15.06206 48.18524  1.000 26.09270 ? 85   ASN A CA  1 
ATOM   694  C C   . ASN A  1 86  ? -22.48447 -15.84951 47.39067  1.000 28.37961 ? 85   ASN A C   1 
ATOM   695  O O   . ASN A  1 86  ? -22.13485 -16.83089 46.72034  1.000 23.75727 ? 85   ASN A O   1 
ATOM   696  C CB  . ASN A  1 86  ? -20.18410 -14.78534 47.36494  1.000 25.03778 ? 85   ASN A CB  1 
ATOM   697  C CG  . ASN A  1 86  ? -20.45638 -13.99957 46.08186  1.000 26.21472 ? 85   ASN A CG  1 
ATOM   698  O OD1 . ASN A  1 86  ? -21.60102 -13.66986 45.75605  1.000 24.02890 ? 85   ASN A OD1 1 
ATOM   699  N ND2 . ASN A  1 86  ? -19.38297 -13.67969 45.35004  1.000 21.06039 ? 85   ASN A ND2 1 
ATOM   700  N N   . PRO A  1 87  ? -23.76522 -15.46658 47.46529  1.000 28.79108 ? 86   PRO A N   1 
ATOM   701  C CA  . PRO A  1 87  ? -24.81429 -16.20686 46.74897  1.000 28.95353 ? 86   PRO A CA  1 
ATOM   702  C C   . PRO A  1 87  ? -24.77699 -16.02652 45.24083  1.000 27.52338 ? 86   PRO A C   1 
ATOM   703  O O   . PRO A  1 87  ? -25.60387 -16.62516 44.54292  1.000 26.45071 ? 86   PRO A O   1 
ATOM   704  C CB  . PRO A  1 87  ? -26.11004 -15.62585 47.33551  1.000 33.06944 ? 86   PRO A CB  1 
ATOM   705  C CG  . PRO A  1 87  ? -25.73890 -14.24426 47.74846  1.000 38.46881 ? 86   PRO A CG  1 
ATOM   706  C CD  . PRO A  1 87  ? -24.31554 -14.34293 48.24752  1.000 34.23623 ? 86   PRO A CD  1 
ATOM   707  N N   . SER A  1 88  ? -23.87813 -15.19711 44.71661  1.000 22.95897 ? 87   SER A N   1 
ATOM   708  C CA  . SER A  1 88  ? -23.67867 -15.09795 43.28271  1.000 22.19394 ? 87   SER A CA  1 
ATOM   709  C C   . SER A  1 88  ? -22.51687 -15.94836 42.79470  1.000 23.68498 ? 87   SER A C   1 
ATOM   710  O O   . SER A  1 88  ? -22.33939 -16.08395 41.58270  1.000 22.04280 ? 87   SER A O   1 
ATOM   711  C CB  . SER A  1 88  ? -23.43088 -13.63992 42.87683  1.000 28.63498 ? 87   SER A CB  1 
ATOM   712  O OG  . SER A  1 88  ? -24.58941 -12.85353 43.07307  1.000 33.65306 ? 87   SER A OG  1 
ATOM   713  N N   . LEU A  1 89  ? -21.72836 -16.51420 43.69901  1.000 20.08552 ? 88   LEU A N   1 
ATOM   714  C CA  . LEU A  1 89  ? -20.48948 -17.18329 43.31670  1.000 19.07514 ? 88   LEU A CA  1 
ATOM   715  C C   . LEU A  1 89  ? -20.76612 -18.54801 42.70362  1.000 21.39738 ? 88   LEU A C   1 
ATOM   716  O O   . LEU A  1 89  ? -21.56533 -19.32843 43.22946  1.000 18.23564 ? 88   LEU A O   1 
ATOM   717  C CB  . LEU A  1 89  ? -19.59004 -17.34462 44.54966  1.000 16.88477 ? 88   LEU A CB  1 
ATOM   718  C CG  . LEU A  1 89  ? -18.25563 -18.09065 44.40385  1.000 16.89035 ? 88   LEU A CG  1 
ATOM   719  C CD1 . LEU A  1 89  ? -17.32505 -17.33181 43.46260  1.000 18.92923 ? 88   LEU A CD1 1 
ATOM   720  C CD2 . LEU A  1 89  ? -17.58826 -18.32412 45.77561  1.000 17.66114 ? 88   LEU A CD2 1 
ATOM   721  N N   . ARG A  1 90  ? -20.07385 -18.84704 41.60105  1.000 17.69128 ? 89   ARG A N   1 
ATOM   722  C CA  . ARG A  1 90  ? -20.09833 -20.16363 40.98669  1.000 16.02027 ? 89   ARG A CA  1 
ATOM   723  C C   . ARG A  1 90  ? -18.71860 -20.79953 41.03030  1.000 16.27605 ? 89   ARG A C   1 
ATOM   724  O O   . ARG A  1 90  ? -17.71919 -20.14411 40.70360  1.000 17.99686 ? 89   ARG A O   1 
ATOM   725  C CB  . ARG A  1 90  ? -20.54493 -20.07919 39.51944  1.000 14.82005 ? 89   ARG A CB  1 
ATOM   726  C CG  . ARG A  1 90  ? -22.00538 -19.70336 39.32863  1.000 14.24951 ? 89   ARG A CG  1 
ATOM   727  C CD  . ARG A  1 90  ? -22.30240 -19.57457 37.83087  1.000 17.23790 ? 89   ARG A CD  1 
ATOM   728  N NE  . ARG A  1 90  ? -23.73382 -19.49292 37.55364  1.000 17.81777 ? 89   ARG A NE  1 
ATOM   729  C CZ  . ARG A  1 90  ? -24.40547 -18.35864 37.43754  1.000 17.71565 ? 89   ARG A CZ  1 
ATOM   730  N NH1 . ARG A  1 90  ? -23.82322 -17.18128 37.64569  1.000 18.26302 ? 89   ARG A NH1 1 
ATOM   731  N NH2 . ARG A  1 90  ? -25.69037 -18.40195 37.10445  1.000 18.65032 ? 89   ARG A NH2 1 
ATOM   732  N N   . ILE A  1 91  ? -18.67152 -22.08935 41.37476  1.000 15.50633 ? 90   ILE A N   1 
ATOM   733  C CA  . ILE A  1 91  ? -17.46035 -22.88982 41.23841  1.000 16.55726 ? 90   ILE A CA  1 
ATOM   734  C C   . ILE A  1 91  ? -17.60697 -23.67755 39.93654  1.000 17.26669 ? 90   ILE A C   1 
ATOM   735  O O   . ILE A  1 91  ? -18.24867 -24.73310 39.89945  1.000 17.82774 ? 90   ILE A O   1 
ATOM   736  C CB  . ILE A  1 91  ? -17.21785 -23.82442 42.42690  1.000 17.32410 ? 90   ILE A CB  1 
ATOM   737  C CG1 . ILE A  1 91  ? -17.33800 -23.09474 43.78144  1.000 14.99559 ? 90   ILE A CG1 1 
ATOM   738  C CG2 . ILE A  1 91  ? -15.83696 -24.47431 42.29904  1.000 17.96943 ? 90   ILE A CG2 1 
ATOM   739  C CD1 . ILE A  1 91  ? -16.46893 -21.85463 43.89986  1.000 17.04795 ? 90   ILE A CD1 1 
ATOM   740  N N   A MET A  1 92  ? -17.02984 -23.14394 38.86615  0.885 17.45467 ? 91   MET A N   1 
ATOM   741  N N   B MET A  1 92  ? -17.01280 -23.17580 38.86196  0.115 17.37885 ? 91   MET A N   1 
ATOM   742  C CA  A MET A  1 92  ? -16.94552 -23.85805 37.60263  0.885 16.91492 ? 91   MET A CA  1 
ATOM   743  C CA  B MET A  1 92  ? -17.01602 -23.88376 37.59022  0.115 16.86039 ? 91   MET A CA  1 
ATOM   744  C C   A MET A  1 92  ? -15.83150 -24.89523 37.67081  0.885 19.09345 ? 91   MET A C   1 
ATOM   745  C C   B MET A  1 92  ? -15.75416 -24.72791 37.47160  0.115 18.26610 ? 91   MET A C   1 
ATOM   746  O O   A MET A  1 92  ? -14.96564 -24.85583 38.54261  0.885 15.84260 ? 91   MET A O   1 
ATOM   747  O O   B MET A  1 92  ? -14.71469 -24.39675 38.04774  0.115 15.93600 ? 91   MET A O   1 
ATOM   748  C CB  A MET A  1 92  ? -16.67351 -22.89002 36.44262  0.885 14.76326 ? 91   MET A CB  1 
ATOM   749  C CB  B MET A  1 92  ? -17.09604 -22.89611 36.42565  0.115 16.31015 ? 91   MET A CB  1 
ATOM   750  C CG  A MET A  1 92  ? -17.56753 -21.65306 36.41083  0.885 16.90815 ? 91   MET A CG  1 
ATOM   751  C CG  B MET A  1 92  ? -17.80301 -21.59357 36.77360  0.115 16.62103 ? 91   MET A CG  1 
ATOM   752  S SD  A MET A  1 92  ? -19.22277 -22.03939 35.79732  0.885 15.93496 ? 91   MET A SD  1 
ATOM   753  S SD  B MET A  1 92  ? -19.22488 -21.23565 35.72415  0.115 13.73079 ? 91   MET A SD  1 
ATOM   754  C CE  A MET A  1 92  ? -18.89052 -22.15308 34.03077  0.885 15.15841 ? 91   MET A CE  1 
ATOM   755  C CE  B MET A  1 92  ? -18.85304 -22.24361 34.28896  0.115 15.57865 ? 91   MET A CE  1 
ATOM   756  N N   . PHE A  1 93  ? -15.84353 -25.82731 36.72303  1.000 15.89569 ? 92   PHE A N   1 
ATOM   757  C CA  . PHE A  1 93  ? -14.66886 -26.65339 36.47338  1.000 15.28250 ? 92   PHE A CA  1 
ATOM   758  C C   . PHE A  1 93  ? -14.29524 -26.54441 35.00759  1.000 15.36220 ? 92   PHE A C   1 
ATOM   759  O O   . PHE A  1 93  ? -15.17019 -26.40481 34.14253  1.000 15.32293 ? 92   PHE A O   1 
ATOM   760  C CB  . PHE A  1 93  ? -14.84998 -28.12081 36.89790  1.000 16.05269 ? 92   PHE A CB  1 
ATOM   761  C CG  . PHE A  1 93  ? -15.70402 -28.95536 35.97664  1.000 16.49248 ? 92   PHE A CG  1 
ATOM   762  C CD1 . PHE A  1 93  ? -17.08881 -28.91095 36.07249  1.000 16.83198 ? 92   PHE A CD1 1 
ATOM   763  C CD2 . PHE A  1 93  ? -15.12618 -29.82869 35.06228  1.000 17.12853 ? 92   PHE A CD2 1 
ATOM   764  C CE1 . PHE A  1 93  ? -17.89207 -29.69865 35.26661  1.000 16.27569 ? 92   PHE A CE1 1 
ATOM   765  C CE2 . PHE A  1 93  ? -15.92480 -30.62289 34.24239  1.000 20.11244 ? 92   PHE A CE2 1 
ATOM   766  C CZ  . PHE A  1 93  ? -17.31080 -30.55855 34.34784  1.000 19.23002 ? 92   PHE A CZ  1 
ATOM   767  N N   . SER A  1 94  ? -12.98816 -26.55778 34.75434  1.000 14.57283 ? 93   SER A N   1 
ATOM   768  C CA  . SER A  1 94  ? -12.42621 -26.34589 33.42785  1.000 13.51860 ? 93   SER A CA  1 
ATOM   769  C C   . SER A  1 94  ? -11.84845 -27.64901 32.91198  1.000 16.74073 ? 93   SER A C   1 
ATOM   770  O O   . SER A  1 94  ? -11.09305 -28.32617 33.62329  1.000 17.35195 ? 93   SER A O   1 
ATOM   771  C CB  . SER A  1 94  ? -11.33696 -25.26631 33.43964  1.000 15.74040 ? 93   SER A CB  1 
ATOM   772  O OG  . SER A  1 94  ? -11.85828 -24.01473 33.86569  1.000 17.58016 ? 93   SER A OG  1 
ATOM   773  N N   . ILE A  1 95  ? -12.17663 -27.96606 31.65835  1.000 14.95135 ? 94   ILE A N   1 
ATOM   774  C CA  . ILE A  1 95  ? -11.66474 -29.13032 30.95711  1.000 17.72476 ? 94   ILE A CA  1 
ATOM   775  C C   . ILE A  1 95  ? -10.65448 -28.64814 29.93065  1.000 17.60581 ? 94   ILE A C   1 
ATOM   776  O O   . ILE A  1 95  ? -10.96655 -27.78308 29.10019  1.000 19.64448 ? 94   ILE A O   1 
ATOM   777  C CB  . ILE A  1 95  ? -12.80879 -29.89484 30.27442  1.000 17.16290 ? 94   ILE A CB  1 
ATOM   778  C CG1 . ILE A  1 95  ? -13.89175 -30.19202 31.31315  1.000 20.79313 ? 94   ILE A CG1 1 
ATOM   779  C CG2 . ILE A  1 95  ? -12.29618 -31.14899 29.58425  1.000 22.08823 ? 94   ILE A CG2 1 
ATOM   780  C CD1 . ILE A  1 95  ? -15.24442 -30.28242 30.68782  1.000 26.74254 ? 94   ILE A CD1 1 
ATOM   781  N N   . GLY A  1 96  ? -9.45399  -29.21288 29.97426  1.000 17.66481 ? 95   GLY A N   1 
ATOM   782  C CA  . GLY A  1 96  ? -8.48318  -28.92055 28.93947  1.000 16.25724 ? 95   GLY A CA  1 
ATOM   783  C C   . GLY A  1 96  ? -7.27787  -28.18241 29.47984  1.000 17.12076 ? 95   GLY A C   1 
ATOM   784  O O   . GLY A  1 96  ? -6.56189  -28.68373 30.35505  1.000 18.23971 ? 95   GLY A O   1 
ATOM   785  N N   . GLY A  1 97  ? -7.06779  -26.96900 28.99721  1.000 16.37711 ? 96   GLY A N   1 
ATOM   786  C CA  . GLY A  1 97  ? -5.83404  -26.25939 29.25375  1.000 16.36725 ? 96   GLY A CA  1 
ATOM   787  C C   . GLY A  1 97  ? -4.76885  -26.64748 28.24796  1.000 18.52082 ? 96   GLY A C   1 
ATOM   788  O O   . GLY A  1 97  ? -4.90058  -27.60788 27.48537  1.000 18.15497 ? 96   GLY A O   1 
ATOM   789  N N   . TRP A  1 98  ? -3.68526  -25.87257 28.24844  1.000 18.54110 ? 97   TRP A N   1 
ATOM   790  C CA  . TRP A  1 98  ? -2.64640  -26.06010 27.23955  1.000 20.71647 ? 97   TRP A CA  1 
ATOM   791  C C   . TRP A  1 98  ? -2.01369  -27.44520 27.34285  1.000 21.63140 ? 97   TRP A C   1 
ATOM   792  O O   . TRP A  1 98  ? -1.84895  -28.14230 26.33477  1.000 21.39253 ? 97   TRP A O   1 
ATOM   793  C CB  . TRP A  1 98  ? -1.57938  -24.97227 27.37884  1.000 20.41072 ? 97   TRP A CB  1 
ATOM   794  C CG  . TRP A  1 98  ? -0.50695  -25.09547 26.33850  1.000 17.95409 ? 97   TRP A CG  1 
ATOM   795  C CD1 . TRP A  1 98  ? 0.71781   -25.69133 26.48253  1.000 22.08223 ? 97   TRP A CD1 1 
ATOM   796  C CD2 . TRP A  1 98  ? -0.57420  -24.62780 24.98868  1.000 20.51023 ? 97   TRP A CD2 1 
ATOM   797  N NE1 . TRP A  1 98  ? 1.41731   -25.61342 25.29846  1.000 21.33907 ? 97   TRP A NE1 1 
ATOM   798  C CE2 . TRP A  1 98  ? 0.64498   -24.96761 24.36684  1.000 20.22426 ? 97   TRP A CE2 1 
ATOM   799  C CE3 . TRP A  1 98  ? -1.54238  -23.93915 24.24638  1.000 24.38686 ? 97   TRP A CE3 1 
ATOM   800  C CZ2 . TRP A  1 98  ? 0.92306   -24.64205 23.03237  1.000 27.21559 ? 97   TRP A CZ2 1 
ATOM   801  C CZ3 . TRP A  1 98  ? -1.26802  -23.63210 22.90773  1.000 24.63329 ? 97   TRP A CZ3 1 
ATOM   802  C CH2 . TRP A  1 98  ? -0.04267  -23.97866 22.32558  1.000 27.57844 ? 97   TRP A CH2 1 
ATOM   803  N N   . TYR A  1 99  ? -1.65076  -27.86204 28.55582  1.000 21.34707 ? 98   TYR A N   1 
ATOM   804  C CA  . TYR A  1 99  ? -0.91248  -29.11552 28.70866  1.000 21.00528 ? 98   TYR A CA  1 
ATOM   805  C C   . TYR A  1 99  ? -1.68303  -30.29794 28.12582  1.000 21.59108 ? 98   TYR A C   1 
ATOM   806  O O   . TYR A  1 99  ? -1.12953  -31.10387 27.36613  1.000 22.16199 ? 98   TYR A O   1 
ATOM   807  C CB  . TYR A  1 99  ? -0.59567  -29.35178 30.18408  1.000 21.11670 ? 98   TYR A CB  1 
ATOM   808  C CG  . TYR A  1 99  ? 0.04882   -30.68988 30.43830  1.000 23.45631 ? 98   TYR A CG  1 
ATOM   809  C CD1 . TYR A  1 99  ? 1.38542   -30.91081 30.12296  1.000 28.79417 ? 98   TYR A CD1 1 
ATOM   810  C CD2 . TYR A  1 99  ? -0.68224  -31.73642 30.98964  1.000 28.31769 ? 98   TYR A CD2 1 
ATOM   811  C CE1 . TYR A  1 99  ? 1.97851   -32.15020 30.35975  1.000 31.51031 ? 98   TYR A CE1 1 
ATOM   812  C CE2 . TYR A  1 99  ? -0.10118  -32.97028 31.23074  1.000 32.78529 ? 98   TYR A CE2 1 
ATOM   813  C CZ  . TYR A  1 99  ? 1.22561   -33.16961 30.91425  1.000 33.32177 ? 98   TYR A CZ  1 
ATOM   814  O OH  . TYR A  1 99  ? 1.79210   -34.40134 31.15338  1.000 38.26712 ? 98   TYR A OH  1 
ATOM   815  N N   . TYR A  1 100 ? -2.97305  -30.40029 28.44156  1.000 19.45515 ? 99   TYR A N   1 
ATOM   816  C CA  . TYR A  1 100 ? -3.75840  -31.53621 27.96596  1.000 18.15593 ? 99   TYR A CA  1 
ATOM   817  C C   . TYR A  1 100 ? -4.12523  -31.41581 26.49491  1.000 19.77061 ? 99   TYR A C   1 
ATOM   818  O O   . TYR A  1 100 ? -4.12596  -32.41886 25.77032  1.000 19.15790 ? 99   TYR A O   1 
ATOM   819  C CB  . TYR A  1 100 ? -5.05153  -31.66092 28.77391  1.000 18.33737 ? 99   TYR A CB  1 
ATOM   820  C CG  . TYR A  1 100 ? -4.87689  -32.20268 30.16340  1.000 17.94217 ? 99   TYR A CG  1 
ATOM   821  C CD1 . TYR A  1 100 ? -3.94661  -33.19505 30.43677  1.000 22.20327 ? 99   TYR A CD1 1 
ATOM   822  C CD2 . TYR A  1 100 ? -5.64752  -31.71601 31.20646  1.000 16.40841 ? 99   TYR A CD2 1 
ATOM   823  C CE1 . TYR A  1 100 ? -3.79312  -33.68802 31.71967  1.000 23.60612 ? 99   TYR A CE1 1 
ATOM   824  C CE2 . TYR A  1 100 ? -5.50855  -32.20708 32.49541  1.000 19.27435 ? 99   TYR A CE2 1 
ATOM   825  C CZ  . TYR A  1 100 ? -4.57600  -33.18880 32.74149  1.000 23.83967 ? 99   TYR A CZ  1 
ATOM   826  O OH  . TYR A  1 100 ? -4.42473  -33.67319 34.02128  1.000 23.18808 ? 99   TYR A OH  1 
ATOM   827  N N   . SER A  1 101 ? -4.48407  -30.21521 26.04255  1.000 19.75753 ? 100  SER A N   1 
ATOM   828  C CA  . SER A  1 101 ? -5.25956  -30.08747 24.81708  1.000 15.80900 ? 100  SER A CA  1 
ATOM   829  C C   . SER A  1 101 ? -4.56444  -29.35103 23.68417  1.000 18.03249 ? 100  SER A C   1 
ATOM   830  O O   . SER A  1 101 ? -5.16414  -29.21599 22.61370  1.000 17.18349 ? 100  SER A O   1 
ATOM   831  C CB  . SER A  1 101 ? -6.60018  -29.39098 25.11802  1.000 18.21089 ? 100  SER A CB  1 
ATOM   832  O OG  . SER A  1 101 ? -6.41577  -27.98970 25.25697  1.000 16.24535 ? 100  SER A OG  1 
ATOM   833  N N   . ASN A  1 102 ? -3.33612  -28.86820 23.86457  1.000 19.62194 ? 101  ASN A N   1 
ATOM   834  C CA  . ASN A  1 102 ? -2.66984  -28.24234 22.73379  1.000 20.35607 ? 101  ASN A CA  1 
ATOM   835  C C   . ASN A  1 102 ? -2.43035  -29.28874 21.64102  1.000 18.01282 ? 101  ASN A C   1 
ATOM   836  O O   . ASN A  1 102 ? -2.58441  -30.49607 21.85750  1.000 18.18962 ? 101  ASN A O   1 
ATOM   837  C CB  . ASN A  1 102 ? -1.37696  -27.54485 23.18208  1.000 21.14280 ? 101  ASN A CB  1 
ATOM   838  C CG  . ASN A  1 102 ? -0.18049  -28.48607 23.27924  1.000 22.74241 ? 101  ASN A CG  1 
ATOM   839  O OD1 . ASN A  1 102 ? 0.46709   -28.78059 22.27676  1.000 23.05180 ? 101  ASN A OD1 1 
ATOM   840  N ND2 . ASN A  1 102 ? 0.14258   -28.91927 24.49618  1.000 20.56688 ? 101  ASN A ND2 1 
ATOM   841  N N   . ASP A  1 103 ? -2.08896  -28.79927 20.44447  1.000 18.12470 ? 102  ASP A N   1 
ATOM   842  C CA  . ASP A  1 103 ? -1.96670  -29.66769 19.27134  1.000 20.31381 ? 102  ASP A CA  1 
ATOM   843  C C   . ASP A  1 103 ? -1.06598  -30.86767 19.53198  1.000 22.36307 ? 102  ASP A C   1 
ATOM   844  O O   . ASP A  1 103 ? -1.30017  -31.95091 18.98243  1.000 22.55024 ? 102  ASP A O   1 
ATOM   845  C CB  . ASP A  1 103 ? -1.40551  -28.88958 18.08487  1.000 21.14987 ? 102  ASP A CB  1 
ATOM   846  C CG  . ASP A  1 103 ? -2.38294  -27.87944 17.52119  1.000 25.64712 ? 102  ASP A CG  1 
ATOM   847  O OD1 . ASP A  1 103 ? -3.57847  -27.93909 17.84837  1.000 19.89712 ? 102  ASP A OD1 1 
ATOM   848  O OD2 . ASP A  1 103 ? -1.94659  -27.03271 16.72337  1.000 28.17982 ? 102  ASP A OD2 1 
ATOM   849  N N   . LEU A  1 104 ? -0.02181  -30.68655 20.34136  1.000 21.58383 ? 103  LEU A N   1 
ATOM   850  C CA  . LEU A  1 104 ? 0.90646   -31.75402 20.68934  1.000 25.10449 ? 103  LEU A CA  1 
ATOM   851  C C   . LEU A  1 104 ? 0.71230   -32.23405 22.12171  1.000 29.19262 ? 103  LEU A C   1 
ATOM   852  O O   . LEU A  1 104 ? 1.59566   -32.89681 22.67922  1.000 26.02469 ? 103  LEU A O   1 
ATOM   853  C CB  . LEU A  1 104 ? 2.34372   -31.27711 20.48042  1.000 26.70555 ? 103  LEU A CB  1 
ATOM   854  C CG  . LEU A  1 104 ? 2.62679   -30.86034 19.03080  1.000 26.54809 ? 103  LEU A CG  1 
ATOM   855  C CD1 . LEU A  1 104 ? 4.01026   -30.23710 18.88967  1.000 41.71790 ? 103  LEU A CD1 1 
ATOM   856  C CD2 . LEU A  1 104 ? 2.42396   -32.02017 18.06389  1.000 34.31278 ? 103  LEU A CD2 1 
ATOM   857  N N   . GLY A  1 105 ? -0.43106  -31.91251 22.73482  1.000 21.76513 ? 104  GLY A N   1 
ATOM   858  C CA  . GLY A  1 105 ? -0.63048  -32.23744 24.13521  1.000 21.37887 ? 104  GLY A CA  1 
ATOM   859  C C   . GLY A  1 105 ? -0.96140  -33.69850 24.36884  1.000 20.76877 ? 104  GLY A C   1 
ATOM   860  O O   . GLY A  1 105 ? -1.37030  -34.42427 23.46545  1.000 24.46598 ? 104  GLY A O   1 
ATOM   861  N N   . VAL A  1 106 ? -0.81650  -34.11644 25.62970  1.000 20.33488 ? 105  VAL A N   1 
ATOM   862  C CA  . VAL A  1 106 ? -0.89439  -35.53940 25.95021  1.000 24.15895 ? 105  VAL A CA  1 
ATOM   863  C C   . VAL A  1 106 ? -2.26903  -36.11876 25.64189  1.000 27.74986 ? 105  VAL A C   1 
ATOM   864  O O   . VAL A  1 106 ? -2.38424  -37.30170 25.30872  1.000 27.60010 ? 105  VAL A O   1 
ATOM   865  C CB  . VAL A  1 106 ? -0.50109  -35.77815 27.41852  1.000 26.61457 ? 105  VAL A CB  1 
ATOM   866  C CG1 . VAL A  1 106 ? 0.93757   -35.33386 27.64457  1.000 37.49248 ? 105  VAL A CG1 1 
ATOM   867  C CG2 . VAL A  1 106 ? -1.45048  -35.05118 28.36447  1.000 23.06947 ? 105  VAL A CG2 1 
ATOM   868  N N   . SER A  1 107 ? -3.32796  -35.31281 25.71928  1.000 19.60067 ? 106  SER A N   1 
ATOM   869  C CA  . SER A  1 107 ? -4.67633  -35.83382 25.52566  1.000 18.47230 ? 106  SER A CA  1 
ATOM   870  C C   . SER A  1 107 ? -5.33825  -35.32012 24.25455  1.000 18.88299 ? 106  SER A C   1 
ATOM   871  O O   . SER A  1 107 ? -6.55542  -35.46582 24.09903  1.000 19.70248 ? 106  SER A O   1 
ATOM   872  C CB  . SER A  1 107 ? -5.55107  -35.49503 26.72711  1.000 19.63731 ? 106  SER A CB  1 
ATOM   873  O OG  . SER A  1 107 ? -4.97517  -35.99441 27.92026  1.000 22.55804 ? 106  SER A OG  1 
ATOM   874  N N   . HIS A  1 108 ? -4.56236  -34.75095 23.33087  1.000 19.02658 ? 107  HIS A N   1 
ATOM   875  C CA  . HIS A  1 108 ? -5.15889  -33.98867 22.23872  1.000 19.08375 ? 107  HIS A CA  1 
ATOM   876  C C   . HIS A  1 108 ? -6.15189  -34.81223 21.42124  1.000 21.64347 ? 107  HIS A C   1 
ATOM   877  O O   . HIS A  1 108 ? -7.22466  -34.31873 21.07022  1.000 18.23806 ? 107  HIS A O   1 
ATOM   878  C CB  . HIS A  1 108 ? -4.07870  -33.44032 21.31526  1.000 19.34083 ? 107  HIS A CB  1 
ATOM   879  C CG  . HIS A  1 108 ? -4.63433  -32.67495 20.16204  1.000 19.36573 ? 107  HIS A CG  1 
ATOM   880  N ND1 . HIS A  1 108 ? -4.68130  -33.18099 18.87963  1.000 19.36300 ? 107  HIS A ND1 1 
ATOM   881  C CD2 . HIS A  1 108 ? -5.21581  -31.45368 20.10974  1.000 18.16399 ? 107  HIS A CD2 1 
ATOM   882  C CE1 . HIS A  1 108 ? -5.23576  -32.28746 18.07977  1.000 20.29790 ? 107  HIS A CE1 1 
ATOM   883  N NE2 . HIS A  1 108 ? -5.57871  -31.23455 18.80236  1.000 20.64615 ? 107  HIS A NE2 1 
ATOM   884  N N   . ALA A  1 109 ? -5.80652  -36.05593 21.07782  1.000 19.54891 ? 108  ALA A N   1 
ATOM   885  C CA  . ALA A  1 109 ? -6.69391  -36.84430 20.22154  1.000 21.42777 ? 108  ALA A CA  1 
ATOM   886  C C   . ALA A  1 109 ? -8.05074  -37.08017 20.88145  1.000 18.49650 ? 108  ALA A C   1 
ATOM   887  O O   . ALA A  1 109 ? -9.05782  -37.26810 20.18542  1.000 20.54944 ? 108  ALA A O   1 
ATOM   888  C CB  . ALA A  1 109 ? -6.03613  -38.18449 19.86841  1.000 23.38088 ? 108  ALA A CB  1 
ATOM   889  N N   . ASN A  1 110 ? -8.09832  -37.07234 22.21141  1.000 18.62103 ? 109  ASN A N   1 
ATOM   890  C CA  . ASN A  1 110 ? -9.36691  -37.27250 22.89996  1.000 22.50511 ? 109  ASN A CA  1 
ATOM   891  C C   . ASN A  1 110 ? -10.30877 -36.10215 22.67771  1.000 18.67222 ? 109  ASN A C   1 
ATOM   892  O O   . ASN A  1 110 ? -11.52423 -36.30493 22.60729  1.000 18.41560 ? 109  ASN A O   1 
ATOM   893  C CB  . ASN A  1 110 ? -9.14494  -37.47456 24.39543  1.000 18.93167 ? 109  ASN A CB  1 
ATOM   894  C CG  . ASN A  1 110 ? -8.21804  -38.63373 24.69597  1.000 22.30738 ? 109  ASN A CG  1 
ATOM   895  O OD1 . ASN A  1 110 ? -8.01955  -39.51642 23.85806  1.000 22.38117 ? 109  ASN A OD1 1 
ATOM   896  N ND2 . ASN A  1 110 ? -7.64659  -38.63790 25.89778  1.000 20.50605 ? 109  ASN A ND2 1 
ATOM   897  N N   . TYR A  1 111 ? -9.77294  -34.88354 22.58335  1.000 16.82416 ? 110  TYR A N   1 
ATOM   898  C CA  . TYR A  1 111 ? -10.60324 -33.72274 22.26469  1.000 16.85354 ? 110  TYR A CA  1 
ATOM   899  C C   . TYR A  1 111 ? -11.15474 -33.84093 20.85251  1.000 20.27048 ? 110  TYR A C   1 
ATOM   900  O O   . TYR A  1 111 ? -12.35761 -33.66727 20.62243  1.000 17.50793 ? 110  TYR A O   1 
ATOM   901  C CB  . TYR A  1 111 ? -9.79606  -32.42301 22.45212  1.000 18.62737 ? 110  TYR A CB  1 
ATOM   902  C CG  . TYR A  1 111 ? -9.51108  -32.20665 23.92076  1.000 17.48404 ? 110  TYR A CG  1 
ATOM   903  C CD1 . TYR A  1 111 ? -8.56670  -32.98594 24.58263  1.000 17.41301 ? 110  TYR A CD1 1 
ATOM   904  C CD2 . TYR A  1 111 ? -10.25025 -31.28999 24.67253  1.000 17.58518 ? 110  TYR A CD2 1 
ATOM   905  C CE1 . TYR A  1 111 ? -8.33893  -32.84072 25.94591  1.000 16.40959 ? 110  TYR A CE1 1 
ATOM   906  C CE2 . TYR A  1 111 ? -10.01899 -31.13472 26.04726  1.000 16.89113 ? 110  TYR A CE2 1 
ATOM   907  C CZ  . TYR A  1 111 ? -9.06884  -31.92352 26.66910  1.000 18.94187 ? 110  TYR A CZ  1 
ATOM   908  O OH  . TYR A  1 111 ? -8.82316  -31.81265 28.01962  1.000 18.46873 ? 110  TYR A OH  1 
ATOM   909  N N   . VAL A  1 112 ? -10.28513 -34.16531 19.89910  1.000 16.50166 ? 111  VAL A N   1 
ATOM   910  C CA  . VAL A  1 112 ? -10.71393 -34.33909 18.51570  1.000 17.87125 ? 111  VAL A CA  1 
ATOM   911  C C   . VAL A  1 112 ? -11.79953 -35.40148 18.42658  1.000 17.32285 ? 111  VAL A C   1 
ATOM   912  O O   . VAL A  1 112 ? -12.83862 -35.20735 17.78314  1.000 17.53401 ? 111  VAL A O   1 
ATOM   913  C CB  . VAL A  1 112 ? -9.50406  -34.69964 17.63554  1.000 21.04773 ? 111  VAL A CB  1 
ATOM   914  C CG1 . VAL A  1 112 ? -9.95625  -34.94580 16.19820  1.000 18.04507 ? 111  VAL A CG1 1 
ATOM   915  C CG2 . VAL A  1 112 ? -8.48409  -33.59326 17.69209  1.000 19.41216 ? 111  VAL A CG2 1 
ATOM   916  N N   . ASN A  1 113 ? -11.58444 -36.53812 19.08385  1.000 18.28488 ? 112  ASN A N   1 
ATOM   917  C CA  . ASN A  1 113 ? -12.50858 -37.64813 18.90368  1.000 20.39915 ? 112  ASN A CA  1 
ATOM   918  C C   . ASN A  1 113 ? -13.80397 -37.46010 19.68315  1.000 21.36623 ? 112  ASN A C   1 
ATOM   919  O O   . ASN A  1 113 ? -14.85788 -37.93056 19.23485  1.000 18.59853 ? 112  ASN A O   1 
ATOM   920  C CB  . ASN A  1 113 ? -11.81901 -38.96012 19.28612  1.000 18.73423 ? 112  ASN A CB  1 
ATOM   921  C CG  . ASN A  1 113 ? -10.77897 -39.37941 18.24242  1.000 23.16459 ? 112  ASN A CG  1 
ATOM   922  O OD1 . ASN A  1 113 ? -10.95486 -39.11738 17.05893  1.000 23.42404 ? 112  ASN A OD1 1 
ATOM   923  N ND2 . ASN A  1 113 ? -9.69598  -40.01100 18.68153  1.000 23.73928 ? 112  ASN A ND2 1 
ATOM   924  N N   . ALA A  1 114 ? -13.75490 -36.78357 20.83564  1.000 19.33232 ? 113  ALA A N   1 
ATOM   925  C CA  . ALA A  1 114 ? -14.95932 -36.61651 21.64750  1.000 18.18100 ? 113  ALA A CA  1 
ATOM   926  C C   . ALA A  1 114 ? -16.02728 -35.79709 20.93346  1.000 16.93783 ? 113  ALA A C   1 
ATOM   927  O O   . ALA A  1 114 ? -17.21856 -35.96416 21.22172  1.000 20.09217 ? 113  ALA A O   1 
ATOM   928  C CB  . ALA A  1 114 ? -14.61569 -35.95794 22.99117  1.000 18.51250 ? 113  ALA A CB  1 
ATOM   929  N N   . VAL A  1 115 ? -15.64233 -34.91044 20.01209  1.000 17.54007 ? 114  VAL A N   1 
ATOM   930  C CA  . VAL A  1 115 ? -16.60837 -34.02102 19.36973  1.000 17.44688 ? 114  VAL A CA  1 
ATOM   931  C C   . VAL A  1 115 ? -16.93131 -34.45848 17.94840  1.000 18.51205 ? 114  VAL A C   1 
ATOM   932  O O   . VAL A  1 115 ? -17.69720 -33.78364 17.26336  1.000 19.60834 ? 114  VAL A O   1 
ATOM   933  C CB  . VAL A  1 115 ? -16.14394 -32.55300 19.39305  1.000 16.30171 ? 114  VAL A CB  1 
ATOM   934  C CG1 . VAL A  1 115 ? -15.77804 -32.11605 20.84694  1.000 17.95763 ? 114  VAL A CG1 1 
ATOM   935  C CG2 . VAL A  1 115 ? -14.99381 -32.30651 18.39285  1.000 18.31621 ? 114  VAL A CG2 1 
ATOM   936  N N   . LYS A  1 116 ? -16.41285 -35.60929 17.51333  1.000 18.28476 ? 115  LYS A N   1 
ATOM   937  C CA  . LYS A  1 116 ? -16.31130 -35.90441 16.08954  1.000 20.22486 ? 115  LYS A CA  1 
ATOM   938  C C   . LYS A  1 116 ? -17.62527 -36.41278 15.49301  1.000 21.71563 ? 115  LYS A C   1 
ATOM   939  O O   . LYS A  1 116 ? -17.86191 -36.22829 14.29093  1.000 22.05939 ? 115  LYS A O   1 
ATOM   940  C CB  . LYS A  1 116 ? -15.18397 -36.92238 15.88714  1.000 18.87029 ? 115  LYS A CB  1 
ATOM   941  C CG  . LYS A  1 116 ? -14.97118 -37.41676 14.46461  1.000 26.16048 ? 115  LYS A CG  1 
ATOM   942  C CD  . LYS A  1 116 ? -13.54725 -37.96274 14.33822  1.000 31.60334 ? 115  LYS A CD  1 
ATOM   943  C CE  . LYS A  1 116 ? -13.31715 -38.65230 13.00194  1.000 53.55910 ? 115  LYS A CE  1 
ATOM   944  N NZ  . LYS A  1 116 ? -12.18746 -39.62472 13.08048  1.000 61.60859 ? 115  LYS A NZ  1 
ATOM   945  N N   . THR A  1 117 ? -18.47393 -37.06524 16.28261  1.000 19.00054 ? 116  THR A N   1 
ATOM   946  C CA  . THR A  1 117 ? -19.69850 -37.68848 15.79590  1.000 21.03043 ? 116  THR A CA  1 
ATOM   947  C C   . THR A  1 117 ? -20.84669 -37.34651 16.73134  1.000 19.70344 ? 116  THR A C   1 
ATOM   948  O O   . THR A  1 117 ? -20.61871 -37.00302 17.89245  1.000 17.66185 ? 116  THR A O   1 
ATOM   949  C CB  . THR A  1 117 ? -19.56731 -39.21734 15.71316  1.000 20.99325 ? 116  THR A CB  1 
ATOM   950  O OG1 . THR A  1 117 ? -19.52543 -39.76179 17.03723  1.000 20.47960 ? 116  THR A OG1 1 
ATOM   951  C CG2 . THR A  1 117 ? -18.30273 -39.63341 14.95652  1.000 23.33680 ? 116  THR A CG2 1 
ATOM   952  N N   . PRO A  1 118 ? -22.09871 -37.45038 16.26242  1.000 19.41977 ? 117  PRO A N   1 
ATOM   953  C CA  . PRO A  1 118 ? -23.23193 -37.21427 17.18180  1.000 19.66104 ? 117  PRO A CA  1 
ATOM   954  C C   . PRO A  1 118 ? -23.19628 -38.09908 18.40969  1.000 18.77561 ? 117  PRO A C   1 
ATOM   955  O O   . PRO A  1 118 ? -23.44182 -37.61862 19.52603  1.000 19.41984 ? 117  PRO A O   1 
ATOM   956  C CB  . PRO A  1 118 ? -24.46018 -37.50812 16.30781  1.000 19.40489 ? 117  PRO A CB  1 
ATOM   957  C CG  . PRO A  1 118 ? -23.99268 -37.19436 14.89817  1.000 19.81329 ? 117  PRO A CG  1 
ATOM   958  C CD  . PRO A  1 118 ? -22.54096 -37.63617 14.86544  1.000 19.84381 ? 117  PRO A CD  1 
ATOM   959  N N   . ALA A  1 119 ? -22.88630 -39.38528 18.24106  1.000 18.76388 ? 118  ALA A N   1 
ATOM   960  C CA  . ALA A  1 119 ? -22.86342 -40.29202 19.38026  1.000 20.80493 ? 118  ALA A CA  1 
ATOM   961  C C   . ALA A  1 119 ? -21.73092 -39.94873 20.33801  1.000 18.78872 ? 118  ALA A C   1 
ATOM   962  O O   . ALA A  1 119 ? -21.89696 -40.02528 21.56301  1.000 19.23009 ? 118  ALA A O   1 
ATOM   963  C CB  . ALA A  1 119 ? -22.73747 -41.73452 18.89491  1.000 22.20325 ? 118  ALA A CB  1 
ATOM   964  N N   . ALA A  1 120 ? -20.56300 -39.59211 19.80359  1.000 17.56447 ? 119  ALA A N   1 
ATOM   965  C CA  . ALA A  1 120 ? -19.46640 -39.19373 20.68560  1.000 20.01579 ? 119  ALA A CA  1 
ATOM   966  C C   . ALA A  1 120 ? -19.82220 -37.92982 21.45730  1.000 17.70557 ? 119  ALA A C   1 
ATOM   967  O O   . ALA A  1 120 ? -19.53084 -37.81768 22.65613  1.000 18.57134 ? 119  ALA A O   1 
ATOM   968  C CB  . ALA A  1 120 ? -18.18640 -38.97676 19.87518  1.000 20.12201 ? 119  ALA A CB  1 
ATOM   969  N N   . ARG A  1 121 ? -20.44289 -36.96434 20.78094  1.000 18.49978 ? 120  ARG A N   1 
ATOM   970  C CA  . ARG A  1 121 ? -20.81447 -35.71476 21.43593  1.000 16.01333 ? 120  ARG A CA  1 
ATOM   971  C C   . ARG A  1 121 ? -21.83960 -35.94768 22.53118  1.000 19.47008 ? 120  ARG A C   1 
ATOM   972  O O   . ARG A  1 121 ? -21.79915 -35.28620 23.57090  1.000 18.54883 ? 120  ARG A O   1 
ATOM   973  C CB  . ARG A  1 121 ? -21.35933 -34.71759 20.41101  1.000 16.02843 ? 120  ARG A CB  1 
ATOM   974  C CG  . ARG A  1 121 ? -20.30691 -34.19582 19.45065  1.000 18.19566 ? 120  ARG A CG  1 
ATOM   975  C CD  . ARG A  1 121 ? -20.84426 -33.09197 18.58214  1.000 18.22397 ? 120  ARG A CD  1 
ATOM   976  N NE  . ARG A  1 121 ? -21.80008 -33.55754 17.57476  1.000 21.11236 ? 120  ARG A NE  1 
ATOM   977  C CZ  . ARG A  1 121 ? -21.48526 -33.88454 16.32895  1.000 22.95526 ? 120  ARG A CZ  1 
ATOM   978  N NH1 . ARG A  1 121 ? -20.22178 -33.92834 15.91892  1.000 19.82281 ? 120  ARG A NH1 1 
ATOM   979  N NH2 . ARG A  1 121 ? -22.46171 -34.16696 15.46592  1.000 20.70508 ? 120  ARG A NH2 1 
ATOM   980  N N   . THR A  1 122 ? -22.77452 -36.87647 22.31716  1.000 16.21564 ? 121  THR A N   1 
ATOM   981  C CA  . THR A  1 122 ? -23.75987 -37.16862 23.35506  1.000 18.41090 ? 121  THR A CA  1 
ATOM   982  C C   . THR A  1 122 ? -23.08700 -37.76515 24.58062  1.000 19.10293 ? 121  THR A C   1 
ATOM   983  O O   . THR A  1 122 ? -23.33346 -37.33148 25.71202  1.000 19.10116 ? 121  THR A O   1 
ATOM   984  C CB  . THR A  1 122 ? -24.83145 -38.11231 22.81427  1.000 19.49638 ? 121  THR A CB  1 
ATOM   985  O OG1 . THR A  1 122 ? -25.59953 -37.41764 21.82667  1.000 19.25973 ? 121  THR A OG1 1 
ATOM   986  C CG2 . THR A  1 122 ? -25.74956 -38.58113 23.92859  1.000 22.21539 ? 121  THR A CG2 1 
ATOM   987  N N   . LYS A  1 123 ? -22.20380 -38.74247 24.36598  1.000 17.91933 ? 122  LYS A N   1 
ATOM   988  C CA  . LYS A  1 123 ? -21.49111 -39.36111 25.47929  1.000 17.31858 ? 122  LYS A CA  1 
ATOM   989  C C   . LYS A  1 123 ? -20.62355 -38.34331 26.20914  1.000 17.79718 ? 122  LYS A C   1 
ATOM   990  O O   . LYS A  1 123 ? -20.60247 -38.30263 27.44811  1.000 17.86611 ? 122  LYS A O   1 
ATOM   991  C CB  . LYS A  1 123 ? -20.64187 -40.51884 24.95473  1.000 18.91943 ? 122  LYS A CB  1 
ATOM   992  C CG  . LYS A  1 123 ? -19.95324 -41.32698 26.05563  1.000 19.64504 ? 122  LYS A CG  1 
ATOM   993  C CD  . LYS A  1 123 ? -19.10861 -42.43609 25.42164  1.000 25.64817 ? 122  LYS A CD  1 
ATOM   994  C CE  . LYS A  1 123 ? -18.59670 -43.41142 26.47130  1.000 30.64411 ? 122  LYS A CE  1 
ATOM   995  N NZ  . LYS A  1 123 ? -17.66263 -44.40845 25.86373  1.000 36.27647 ? 122  LYS A NZ  1 
ATOM   996  N N   . PHE A  1 124 ? -19.91681 -37.50158 25.45815  1.000 18.16212 ? 123  PHE A N   1 
ATOM   997  C CA  . PHE A  1 124 ? -19.06282 -36.49252 26.07873  1.000 19.89159 ? 123  PHE A CA  1 
ATOM   998  C C   . PHE A  1 124 ? -19.89527 -35.48797 26.86865  1.000 20.28808 ? 123  PHE A C   1 
ATOM   999  O O   . PHE A  1 124 ? -19.61187 -35.21083 28.04129  1.000 18.89733 ? 123  PHE A O   1 
ATOM   1000 C CB  . PHE A  1 124 ? -18.23158 -35.78759 25.00534  1.000 17.48784 ? 123  PHE A CB  1 
ATOM   1001 C CG  . PHE A  1 124 ? -17.50517 -34.58211 25.50888  1.000 17.73267 ? 123  PHE A CG  1 
ATOM   1002 C CD1 . PHE A  1 124 ? -16.59314 -34.69526 26.54609  1.000 20.35551 ? 123  PHE A CD1 1 
ATOM   1003 C CD2 . PHE A  1 124 ? -17.74174 -33.33494 24.95661  1.000 20.41208 ? 123  PHE A CD2 1 
ATOM   1004 C CE1 . PHE A  1 124 ? -15.92010 -33.57834 27.01190  1.000 21.14508 ? 123  PHE A CE1 1 
ATOM   1005 C CE2 . PHE A  1 124 ? -17.07487 -32.20896 25.43579  1.000 22.02369 ? 123  PHE A CE2 1 
ATOM   1006 C CZ  . PHE A  1 124 ? -16.17156 -32.34089 26.46004  1.000 19.14556 ? 123  PHE A CZ  1 
ATOM   1007 N N   . ALA A  1 125 ? -20.93763 -34.93969 26.24043  1.000 17.40466 ? 124  ALA A N   1 
ATOM   1008 C CA  . ALA A  1 125 ? -21.77426 -33.95134 26.91670  1.000 17.14052 ? 124  ALA A CA  1 
ATOM   1009 C C   . ALA A  1 125 ? -22.38054 -34.51892 28.18860  1.000 20.32727 ? 124  ALA A C   1 
ATOM   1010 O O   . ALA A  1 125 ? -22.39620 -33.85241 29.23234  1.000 19.68857 ? 124  ALA A O   1 
ATOM   1011 C CB  . ALA A  1 125 ? -22.87824 -33.46597 25.97383  1.000 15.74854 ? 124  ALA A CB  1 
ATOM   1012 N N   . GLN A  1 126 ? -22.88916 -35.74931 28.12833  1.000 16.85210 ? 125  GLN A N   1 
ATOM   1013 C CA  . GLN A  1 126 ? -23.43747 -36.35244 29.33965  1.000 16.81092 ? 125  GLN A CA  1 
ATOM   1014 C C   . GLN A  1 126 ? -22.38150 -36.46303 30.43478  1.000 18.37248 ? 125  GLN A C   1 
ATOM   1015 O O   . GLN A  1 126 ? -22.66991 -36.19782 31.60845  1.000 18.74640 ? 125  GLN A O   1 
ATOM   1016 C CB  . GLN A  1 126 ? -24.01865 -37.72740 29.02939  1.000 20.16703 ? 125  GLN A CB  1 
ATOM   1017 C CG  . GLN A  1 126 ? -25.37383 -37.67171 28.34872  1.000 20.68642 ? 125  GLN A CG  1 
ATOM   1018 C CD  . GLN A  1 126 ? -25.80551 -39.01875 27.82520  1.000 35.73769 ? 125  GLN A CD  1 
ATOM   1019 O OE1 . GLN A  1 126 ? -25.07340 -40.00315 27.93240  1.000 39.91497 ? 125  GLN A OE1 1 
ATOM   1020 N NE2 . GLN A  1 126 ? -27.00526 -39.07619 27.26185  1.000 28.57360 ? 125  GLN A NE2 1 
ATOM   1021 N N   . SER A  1 127 ? -21.15226 -36.84666 30.07487  1.000 19.73226 ? 126  SER A N   1 
ATOM   1022 C CA  . SER A  1 127 ? -20.11873 -37.01061 31.09609  1.000 19.16948 ? 126  SER A CA  1 
ATOM   1023 C C   . SER A  1 127 ? -19.77020 -35.68563 31.76817  1.000 19.24355 ? 126  SER A C   1 
ATOM   1024 O O   . SER A  1 127 ? -19.42356 -35.66843 32.95619  1.000 19.87621 ? 126  SER A O   1 
ATOM   1025 C CB  . SER A  1 127 ? -18.86216 -37.65957 30.49376  1.000 19.20968 ? 126  SER A CB  1 
ATOM   1026 O OG  . SER A  1 127 ? -18.17225 -36.78560 29.61630  1.000 19.92305 ? 126  SER A OG  1 
ATOM   1027 N N   A CYS A  1 128 ? -19.81589 -34.57909 31.01009  0.847 18.66978 ? 127  CYS A N   1 
ATOM   1028 N N   B CYS A  1 128 ? -19.89117 -34.56843 31.06796  0.153 18.67797 ? 127  CYS A N   1 
ATOM   1029 C CA  A CYS A  1 128 ? -19.54787 -33.25893 31.58074  0.847 18.93560 ? 127  CYS A CA  1 
ATOM   1030 C CA  B CYS A  1 128 ? -19.49344 -33.31161 31.68399  0.153 18.90435 ? 127  CYS A CA  1 
ATOM   1031 C C   A CYS A  1 128 ? -20.57097 -32.91725 32.65372  0.847 18.43893 ? 127  CYS A C   1 
ATOM   1032 C C   B CYS A  1 128 ? -20.59505 -32.69012 32.53348  0.153 18.72285 ? 127  CYS A C   1 
ATOM   1033 O O   A CYS A  1 128 ? -20.22391 -32.46386 33.75102  0.847 17.42228 ? 127  CYS A O   1 
ATOM   1034 O O   B CYS A  1 128 ? -20.29800 -31.84184 33.38349  0.153 18.31451 ? 127  CYS A O   1 
ATOM   1035 C CB  A CYS A  1 128 ? -19.58024 -32.18355 30.48893  0.847 18.62587 ? 127  CYS A CB  1 
ATOM   1036 C CB  B CYS A  1 128 ? -19.02209 -32.35029 30.60117  0.153 19.47385 ? 127  CYS A CB  1 
ATOM   1037 S SG  A CYS A  1 128 ? -18.23993 -32.19768 29.28383  0.847 19.89562 ? 127  CYS A SG  1 
ATOM   1038 S SG  B CYS A  1 128 ? -17.91952 -33.21817 29.47113  0.153 18.76466 ? 127  CYS A SG  1 
ATOM   1039 N N   . VAL A  1 129 ? -21.85068 -33.09672 32.33604  1.000 17.74037 ? 128  VAL A N   1 
ATOM   1040 C CA  . VAL A  1 129 ? -22.89309 -32.75113 33.29291  1.000 18.40696 ? 128  VAL A CA  1 
ATOM   1041 C C   . VAL A  1 129 ? -22.87485 -33.72826 34.45589  1.000 19.36465 ? 128  VAL A C   1 
ATOM   1042 O O   . VAL A  1 129 ? -23.12609 -33.33806 35.60099  1.000 20.70712 ? 128  VAL A O   1 
ATOM   1043 C CB  . VAL A  1 129 ? -24.26453 -32.69644 32.59215  1.000 16.53052 ? 128  VAL A CB  1 
ATOM   1044 C CG1 . VAL A  1 129 ? -25.36590 -32.34627 33.60163  1.000 23.60677 ? 128  VAL A CG1 1 
ATOM   1045 C CG2 . VAL A  1 129 ? -24.23265 -31.66553 31.45683  1.000 21.24799 ? 128  VAL A CG2 1 
ATOM   1046 N N   . ARG A  1 130 ? -22.55730 -35.00218 34.19942  1.000 20.25980 ? 129  ARG A N   1 
ATOM   1047 C CA  A ARG A  1 130 ? -22.44281 -35.95395 35.30045  0.529 22.80998 ? 129  ARG A CA  1 
ATOM   1048 C CA  B ARG A  1 130 ? -22.42001 -35.97781 35.27728  0.471 22.83381 ? 129  ARG A CA  1 
ATOM   1049 C C   . ARG A  1 130 ? -21.31526 -35.56530 36.24611  1.000 21.81442 ? 129  ARG A C   1 
ATOM   1050 O O   . ARG A  1 130 ? -21.48832 -35.60168 37.47097  1.000 21.00958 ? 129  ARG A O   1 
ATOM   1051 C CB  A ARG A  1 130 ? -22.22032 -37.37370 34.78355  0.529 23.99713 ? 129  ARG A CB  1 
ATOM   1052 C CB  B ARG A  1 130 ? -22.12582 -37.35095 34.67173  0.471 23.89406 ? 129  ARG A CB  1 
ATOM   1053 C CG  A ARG A  1 130 ? -21.77614 -38.32513 35.90068  0.529 21.47811 ? 129  ARG A CG  1 
ATOM   1054 C CG  B ARG A  1 130 ? -22.60085 -38.54259 35.47833  0.471 31.54160 ? 129  ARG A CG  1 
ATOM   1055 C CD  A ARG A  1 130 ? -21.60511 -39.74906 35.42303  0.529 23.78392 ? 129  ARG A CD  1 
ATOM   1056 C CD  B ARG A  1 130 ? -22.78530 -39.74835 34.55951  0.471 27.87487 ? 129  ARG A CD  1 
ATOM   1057 N NE  A ARG A  1 130 ? -20.80746 -39.84390 34.20918  0.529 29.58531 ? 129  ARG A NE  1 
ATOM   1058 N NE  B ARG A  1 130 ? -21.52127 -40.16347 33.96352  0.471 29.77264 ? 129  ARG A NE  1 
ATOM   1059 C CZ  A ARG A  1 130 ? -19.48334 -39.88992 34.18019  0.529 31.31408 ? 129  ARG A CZ  1 
ATOM   1060 C CZ  B ARG A  1 130 ? -21.28618 -40.24003 32.65984  0.471 23.88363 ? 129  ARG A CZ  1 
ATOM   1061 N NH1 A ARG A  1 130 ? -18.76096 -39.79685 35.28760  0.529 28.60094 ? 129  ARG A NH1 1 
ATOM   1062 N NH1 B ARG A  1 130 ? -22.21744 -39.94127 31.76830  0.471 15.65687 ? 129  ARG A NH1 1 
ATOM   1063 N NH2 A ARG A  1 130 ? -18.86889 -40.05431 33.01307  0.529 23.97040 ? 129  ARG A NH2 1 
ATOM   1064 N NH2 B ARG A  1 130 ? -20.08488 -40.62685 32.24116  0.471 29.57764 ? 129  ARG A NH2 1 
ATOM   1065 N N   . ILE A  1 131 ? -20.15703 -35.17816 35.70402  1.000 19.50589 ? 130  ILE A N   1 
ATOM   1066 C CA  . ILE A  1 131 ? -19.06291 -34.72041 36.55920  1.000 19.36367 ? 130  ILE A CA  1 
ATOM   1067 C C   . ILE A  1 131 ? -19.48785 -33.48622 37.34330  1.000 20.45121 ? 130  ILE A C   1 
ATOM   1068 O O   . ILE A  1 131 ? -19.23150 -33.37753 38.55387  1.000 19.99146 ? 130  ILE A O   1 
ATOM   1069 C CB  . ILE A  1 131 ? -17.79878 -34.44801 35.71995  1.000 21.57493 ? 130  ILE A CB  1 
ATOM   1070 C CG1 . ILE A  1 131 ? -17.19139 -35.75726 35.21990  1.000 23.24335 ? 130  ILE A CG1 1 
ATOM   1071 C CG2 . ILE A  1 131 ? -16.77606 -33.64233 36.53338  1.000 23.31283 ? 130  ILE A CG2 1 
ATOM   1072 C CD1 . ILE A  1 131 ? -16.55113 -36.59364 36.32871  1.000 25.18062 ? 130  ILE A CD1 1 
ATOM   1073 N N   . MET A  1 132 ? -20.14705 -32.53932 36.66814  1.000 18.10735 ? 131  MET A N   1 
ATOM   1074 C CA  . MET A  1 132 ? -20.62161 -31.32945 37.32819  1.000 16.84299 ? 131  MET A CA  1 
ATOM   1075 C C   . MET A  1 132 ? -21.47846 -31.66635 38.54095  1.000 21.16092 ? 131  MET A C   1 
ATOM   1076 O O   . MET A  1 132 ? -21.29602 -31.10702 39.62885  1.000 19.73510 ? 131  MET A O   1 
ATOM   1077 C CB  . MET A  1 132 ? -21.44365 -30.48838 36.35519  1.000 17.86963 ? 131  MET A CB  1 
ATOM   1078 C CG  . MET A  1 132 ? -21.73979 -29.08456 36.87366  1.000 18.98903 ? 131  MET A CG  1 
ATOM   1079 S SD  . MET A  1 132 ? -22.94641 -28.24447 35.83607  1.000 19.18926 ? 131  MET A SD  1 
ATOM   1080 C CE  . MET A  1 132 ? -24.41749 -29.20539 36.23792  1.000 21.61191 ? 131  MET A CE  1 
ATOM   1081 N N   . LYS A  1 133 ? -22.44226 -32.56704 38.35167  1.000 20.54675 ? 132  LYS A N   1 
ATOM   1082 C CA  . LYS A  1 133 ? -23.37695 -32.89912 39.42538  1.000 20.03990 ? 132  LYS A CA  1 
ATOM   1083 C C   . LYS A  1 133 ? -22.71249 -33.74041 40.50576  1.000 22.94492 ? 132  LYS A C   1 
ATOM   1084 O O   . LYS A  1 133 ? -22.99621 -33.56891 41.69968  1.000 23.14755 ? 132  LYS A O   1 
ATOM   1085 C CB  . LYS A  1 133 ? -24.58154 -33.63598 38.83962  1.000 23.31021 ? 132  LYS A CB  1 
ATOM   1086 C CG  . LYS A  1 133 ? -25.60950 -32.71958 38.22677  1.000 25.31195 ? 132  LYS A CG  1 
ATOM   1087 C CD  . LYS A  1 133 ? -26.17593 -31.77459 39.28199  1.000 38.02524 ? 132  LYS A CD  1 
ATOM   1088 C CE  . LYS A  1 133 ? -26.93939 -32.54977 40.35595  1.000 33.63584 ? 132  LYS A CE  1 
ATOM   1089 N NZ  . LYS A  1 133 ? -27.57784 -31.63807 41.32831  1.000 41.77205 ? 132  LYS A NZ  1 
ATOM   1090 N N   . ASP A  1 134 ? -21.83229 -34.65675 40.11033  1.000 19.64559 ? 133  ASP A N   1 
ATOM   1091 C CA  . ASP A  1 134 ? -21.25376 -35.58861 41.07136  1.000 21.22166 ? 133  ASP A CA  1 
ATOM   1092 C C   . ASP A  1 134 ? -20.36079 -34.85285 42.07167  1.000 26.20565 ? 133  ASP A C   1 
ATOM   1093 O O   . ASP A  1 134 ? -20.37745 -35.15423 43.27319  1.000 23.69273 ? 133  ASP A O   1 
ATOM   1094 C CB  . ASP A  1 134 ? -20.46759 -36.66907 40.31722  1.000 22.12582 ? 133  ASP A CB  1 
ATOM   1095 C CG  . ASP A  1 134 ? -19.92812 -37.76857 41.23416  1.000 32.04336 ? 133  ASP A CG  1 
ATOM   1096 O OD1 . ASP A  1 134 ? -19.12715 -38.60402 40.75327  1.000 32.95550 ? 133  ASP A OD1 1 
ATOM   1097 O OD2 . ASP A  1 134 ? -20.37221 -37.85471 42.40058  1.000 34.34297 ? 133  ASP A OD2 1 
ATOM   1098 N N   . TYR A  1 135 ? -19.61041 -33.85012 41.60562  1.000 21.15254 ? 134  TYR A N   1 
ATOM   1099 C CA  . TYR A  1 135 ? -18.65697 -33.14893 42.45293  1.000 21.92831 ? 134  TYR A CA  1 
ATOM   1100 C C   . TYR A  1 135 ? -19.18612 -31.82283 42.98059  1.000 21.67815 ? 134  TYR A C   1 
ATOM   1101 O O   . TYR A  1 135 ? -18.54685 -31.22187 43.85099  1.000 20.92199 ? 134  TYR A O   1 
ATOM   1102 C CB  . TYR A  1 135 ? -17.33545 -32.95217 41.69205  1.000 20.81382 ? 134  TYR A CB  1 
ATOM   1103 C CG  . TYR A  1 135 ? -16.66082 -34.29488 41.45747  1.000 22.25721 ? 134  TYR A CG  1 
ATOM   1104 C CD1 . TYR A  1 135 ? -17.01068 -35.09330 40.37219  1.000 19.58087 ? 134  TYR A CD1 1 
ATOM   1105 C CD2 . TYR A  1 135 ? -15.72735 -34.79294 42.35842  1.000 20.31606 ? 134  TYR A CD2 1 
ATOM   1106 C CE1 . TYR A  1 135 ? -16.42757 -36.33977 40.18028  1.000 21.77540 ? 134  TYR A CE1 1 
ATOM   1107 C CE2 . TYR A  1 135 ? -15.14286 -36.03786 42.17461  1.000 20.43165 ? 134  TYR A CE2 1 
ATOM   1108 C CZ  . TYR A  1 135 ? -15.49938 -36.80562 41.09125  1.000 24.48368 ? 134  TYR A CZ  1 
ATOM   1109 O OH  . TYR A  1 135 ? -14.92206 -38.03945 40.91774  1.000 21.34055 ? 134  TYR A OH  1 
ATOM   1110 N N   . GLY A  1 136 ? -20.33842 -31.36777 42.50267  1.000 19.85891 ? 135  GLY A N   1 
ATOM   1111 C CA  . GLY A  1 136 ? -20.96865 -30.18102 43.04362  1.000 18.89271 ? 135  GLY A CA  1 
ATOM   1112 C C   . GLY A  1 136 ? -20.57717 -28.88485 42.37851  1.000 20.92388 ? 135  GLY A C   1 
ATOM   1113 O O   . GLY A  1 136 ? -20.71479 -27.82481 42.99399  1.000 19.33986 ? 135  GLY A O   1 
ATOM   1114 N N   . PHE A  1 137 ? -20.08033 -28.93480 41.14712  1.000 17.05652 ? 136  PHE A N   1 
ATOM   1115 C CA  . PHE A  1 137 ? -19.71215 -27.74710 40.40220  1.000 17.22004 ? 136  PHE A CA  1 
ATOM   1116 C C   . PHE A  1 137 ? -20.96801 -27.03288 39.89344  1.000 16.95878 ? 136  PHE A C   1 
ATOM   1117 O O   . PHE A  1 137 ? -22.06713 -27.59886 39.85411  1.000 19.90022 ? 136  PHE A O   1 
ATOM   1118 C CB  . PHE A  1 137 ? -18.80253 -28.12823 39.22394  1.000 15.86572 ? 136  PHE A CB  1 
ATOM   1119 C CG  . PHE A  1 137 ? -17.43054 -28.61103 39.62630  1.000 16.95122 ? 136  PHE A CG  1 
ATOM   1120 C CD1 . PHE A  1 137 ? -16.53786 -27.76389 40.26458  1.000 16.86154 ? 136  PHE A CD1 1 
ATOM   1121 C CD2 . PHE A  1 137 ? -17.01933 -29.90482 39.31693  1.000 19.37350 ? 136  PHE A CD2 1 
ATOM   1122 C CE1 . PHE A  1 137 ? -15.25301 -28.20011 40.60967  1.000 15.88905 ? 136  PHE A CE1 1 
ATOM   1123 C CE2 . PHE A  1 137 ? -15.74012 -30.34933 39.65099  1.000 17.88208 ? 136  PHE A CE2 1 
ATOM   1124 C CZ  . PHE A  1 137 ? -14.86015 -29.49104 40.30682  1.000 16.96378 ? 136  PHE A CZ  1 
ATOM   1125 N N   . ASP A  1 138 ? -20.79398 -25.77166 39.50326  1.000 15.25965 ? 137  ASP A N   1 
ATOM   1126 C CA  . ASP A  1 138 ? -21.89408 -24.90123 39.11105  1.000 17.56269 ? 137  ASP A CA  1 
ATOM   1127 C C   . ASP A  1 138 ? -21.94321 -24.62965 37.61555  1.000 16.75833 ? 137  ASP A C   1 
ATOM   1128 O O   . ASP A  1 138 ? -22.79179 -23.85125 37.16512  1.000 16.83162 ? 137  ASP A O   1 
ATOM   1129 C CB  . ASP A  1 138 ? -21.79169 -23.58407 39.87878  1.000 16.66152 ? 137  ASP A CB  1 
ATOM   1130 C CG  . ASP A  1 138 ? -21.86860 -23.81237 41.39367  1.000 19.64885 ? 137  ASP A CG  1 
ATOM   1131 O OD1 . ASP A  1 138 ? -22.84001 -24.47188 41.82344  1.000 20.08170 ? 137  ASP A OD1 1 
ATOM   1132 O OD2 . ASP A  1 138 ? -20.95200 -23.39457 42.13682  1.000 17.47890 ? 137  ASP A OD2 1 
ATOM   1133 N N   . GLY A  1 139 ? -21.04912 -25.23021 36.84543  1.000 17.48626 ? 138  GLY A N   1 
ATOM   1134 C CA  . GLY A  1 139 ? -21.05434 -25.03737 35.41106  1.000 16.43705 ? 138  GLY A CA  1 
ATOM   1135 C C   . GLY A  1 139 ? -19.83134 -25.68982 34.80895  1.000 14.89743 ? 138  GLY A C   1 
ATOM   1136 O O   . GLY A  1 139 ? -18.97405 -26.23482 35.51527  1.000 17.30247 ? 138  GLY A O   1 
ATOM   1137 N N   . VAL A  1 140 ? -19.76742 -25.62334 33.48128  1.000 14.86684 ? 139  VAL A N   1 
ATOM   1138 C CA  . VAL A  1 140 ? -18.75213 -26.31060 32.68984  1.000 16.04213 ? 139  VAL A CA  1 
ATOM   1139 C C   . VAL A  1 140 ? -17.98242 -25.26310 31.89965  1.000 14.43142 ? 139  VAL A C   1 
ATOM   1140 O O   . VAL A  1 140 ? -18.58681 -24.41948 31.22831  1.000 17.15365 ? 139  VAL A O   1 
ATOM   1141 C CB  . VAL A  1 140 ? -19.38450 -27.33431 31.72388  1.000 15.96862 ? 139  VAL A CB  1 
ATOM   1142 C CG1 . VAL A  1 140 ? -18.31643 -27.94065 30.80223  1.000 17.37711 ? 139  VAL A CG1 1 
ATOM   1143 C CG2 . VAL A  1 140 ? -20.13065 -28.43142 32.48476  1.000 17.36015 ? 139  VAL A CG2 1 
ATOM   1144 N N   . ASP A  1 141 ? -16.65785 -25.31565 31.97143  1.000 14.87784 ? 140  ASP A N   1 
ATOM   1145 C CA  . ASP A  1 141 ? -15.80298 -24.43677 31.18381  1.000 14.29078 ? 140  ASP A CA  1 
ATOM   1146 C C   . ASP A  1 141 ? -14.89221 -25.31594 30.34218  1.000 15.95203 ? 140  ASP A C   1 
ATOM   1147 O O   . ASP A  1 141 ? -14.25411 -26.22771 30.86934  1.000 17.49124 ? 140  ASP A O   1 
ATOM   1148 C CB  . ASP A  1 141 ? -14.98447 -23.51060 32.10084  1.000 15.36190 ? 140  ASP A CB  1 
ATOM   1149 C CG  . ASP A  1 141 ? -13.98857 -22.67997 31.33103  1.000 15.42645 ? 140  ASP A CG  1 
ATOM   1150 O OD1 . ASP A  1 141 ? -14.41143 -21.82048 30.52607  1.000 16.96483 ? 140  ASP A OD1 1 
ATOM   1151 O OD2 . ASP A  1 141 ? -12.77805 -22.89758 31.54104  1.000 16.21492 ? 140  ASP A OD2 1 
ATOM   1152 N N   A ILE A  1 142 ? -14.85614 -25.05846 29.03552  0.470 15.25364 ? 141  ILE A N   1 
ATOM   1153 N N   B ILE A  1 142 ? -14.84162 -25.07086 29.03974  0.530 15.26521 ? 141  ILE A N   1 
ATOM   1154 C CA  A ILE A  1 142 ? -14.05963 -25.84685 28.10094  0.470 14.84672 ? 141  ILE A CA  1 
ATOM   1155 C CA  B ILE A  1 142 ? -14.03724 -25.90119 28.15409  0.530 14.80954 ? 141  ILE A CA  1 
ATOM   1156 C C   A ILE A  1 142 ? -12.88124 -25.00165 27.65238  0.470 14.93485 ? 141  ILE A C   1 
ATOM   1157 C C   B ILE A  1 142 ? -12.89787 -25.05749 27.61586  0.530 14.91131 ? 141  ILE A C   1 
ATOM   1158 O O   A ILE A  1 142 ? -13.06388 -23.89247 27.13543  0.470 15.29121 ? 141  ILE A O   1 
ATOM   1159 O O   B ILE A  1 142 ? -13.12423 -23.99914 27.01714  0.530 15.26449 ? 141  ILE A O   1 
ATOM   1160 C CB  A ILE A  1 142 ? -14.88387 -26.31204 26.89213  0.470 15.46448 ? 141  ILE A CB  1 
ATOM   1161 C CB  B ILE A  1 142 ? -14.87616 -26.51073 27.02528  0.530 15.60358 ? 141  ILE A CB  1 
ATOM   1162 C CG1 A ILE A  1 142 ? -16.22293 -26.88947 27.35156  0.470 18.20936 ? 141  ILE A CG1 1 
ATOM   1163 C CG1 B ILE A  1 142 ? -15.81532 -27.56235 27.61911  0.530 19.05882 ? 141  ILE A CG1 1 
ATOM   1164 C CG2 A ILE A  1 142 ? -14.08068 -27.33149 26.07694  0.470 18.26286 ? 141  ILE A CG2 1 
ATOM   1165 C CG2 B ILE A  1 142 ? -13.95626 -27.11287 25.95930  0.530 17.92245 ? 141  ILE A CG2 1 
ATOM   1166 C CD1 A ILE A  1 142 ? -16.12716 -28.30091 27.87902  0.470 19.37904 ? 141  ILE A CD1 1 
ATOM   1167 C CD1 B ILE A  1 142 ? -16.84574 -28.08357 26.65361  0.530 16.26465 ? 141  ILE A CD1 1 
ATOM   1168 N N   . ASP A  1 143 ? -11.67038 -25.52532 27.84814  1.000 13.79948 ? 142  ASP A N   1 
ATOM   1169 C CA  . ASP A  1 143 ? -10.46501 -24.81189 27.45427  1.000 14.41162 ? 142  ASP A CA  1 
ATOM   1170 C C   . ASP A  1 143 ? -9.65478  -25.65018 26.48444  1.000 15.23628 ? 142  ASP A C   1 
ATOM   1171 O O   . ASP A  1 143 ? -8.51515  -26.01972 26.77610  1.000 16.44488 ? 142  ASP A O   1 
ATOM   1172 C CB  . ASP A  1 143 ? -9.59124  -24.49125 28.67138  1.000 14.27229 ? 142  ASP A CB  1 
ATOM   1173 C CG  . ASP A  1 143 ? -10.30475 -23.63645 29.70269  1.000 21.27276 ? 142  ASP A CG  1 
ATOM   1174 O OD1 . ASP A  1 143 ? -11.43827 -23.18305 29.44393  1.000 17.47752 ? 142  ASP A OD1 1 
ATOM   1175 O OD2 . ASP A  1 143 ? -9.72439  -23.41910 30.78627  1.000 19.56906 ? 142  ASP A OD2 1 
ATOM   1176 N N   . TRP A  1 144 ? -10.23742 -25.97007 25.33904  1.000 15.20350 ? 143  TRP A N   1 
ATOM   1177 C CA  . TRP A  1 144 ? -9.50330  -26.66423 24.29459  1.000 17.24650 ? 143  TRP A CA  1 
ATOM   1178 C C   . TRP A  1 144 ? -8.69186  -25.62844 23.53314  1.000 16.54828 ? 143  TRP A C   1 
ATOM   1179 O O   . TRP A  1 144 ? -9.25446  -24.68848 22.95664  1.000 16.03348 ? 143  TRP A O   1 
ATOM   1180 C CB  . TRP A  1 144 ? -10.48317 -27.39545 23.38207  1.000 14.92517 ? 143  TRP A CB  1 
ATOM   1181 C CG  . TRP A  1 144 ? -9.88892  -28.12271 22.21319  1.000 15.12832 ? 143  TRP A CG  1 
ATOM   1182 C CD1 . TRP A  1 144 ? -8.58173  -28.17749 21.83207  1.000 16.07100 ? 143  TRP A CD1 1 
ATOM   1183 C CD2 . TRP A  1 144 ? -10.62025 -28.89536 21.26398  1.000 17.21189 ? 143  TRP A CD2 1 
ATOM   1184 N NE1 . TRP A  1 144 ? -8.45486  -28.94233 20.68293  1.000 16.51693 ? 143  TRP A NE1 1 
ATOM   1185 C CE2 . TRP A  1 144 ? -9.69761  -29.40190 20.32963  1.000 17.60005 ? 143  TRP A CE2 1 
ATOM   1186 C CE3 . TRP A  1 144 ? -11.97083 -29.22273 21.12769  1.000 17.45699 ? 143  TRP A CE3 1 
ATOM   1187 C CZ2 . TRP A  1 144 ? -10.08781 -30.20805 19.26212  1.000 21.29625 ? 143  TRP A CZ2 1 
ATOM   1188 C CZ3 . TRP A  1 144 ? -12.35735 -30.01993 20.06771  1.000 18.50069 ? 143  TRP A CZ3 1 
ATOM   1189 C CH2 . TRP A  1 144 ? -11.41529 -30.50596 19.15138  1.000 17.05080 ? 143  TRP A CH2 1 
ATOM   1190 N N   . GLU A  1 145 ? -7.37163  -25.78051 23.54319  1.000 14.44191 ? 144  GLU A N   1 
ATOM   1191 C CA  . GLU A  1 145 ? -6.48363  -24.78946 22.93849  1.000 16.48861 ? 144  GLU A CA  1 
ATOM   1192 C C   . GLU A  1 145 ? -5.71264  -25.42151 21.77689  1.000 19.45910 ? 144  GLU A C   1 
ATOM   1193 O O   . GLU A  1 145 ? -4.54746  -25.77103 21.93317  1.000 19.31582 ? 144  GLU A O   1 
ATOM   1194 C CB  . GLU A  1 145 ? -5.52726  -24.20830 24.08897  1.000 15.92064 ? 144  GLU A CB  1 
ATOM   1195 C CG  . GLU A  1 145 ? -6.37941  -23.71056 25.27156  1.000 15.34962 ? 144  GLU A CG  1 
ATOM   1196 C CD  . GLU A  1 145 ? -5.60703  -23.17521 26.46260  1.000 22.53380 ? 144  GLU A CD  1 
ATOM   1197 O OE1 . GLU A  1 145 ? -4.39861  -22.92171 26.34520  1.000 22.66654 ? 144  GLU A OE1 1 
ATOM   1198 O OE2 . GLU A  1 145 ? -6.25667  -22.99638 27.51522  1.000 23.51052 ? 144  GLU A OE2 1 
ATOM   1199 N N   . TYR A  1 146 ? -6.32861  -25.52694 20.59084  1.000 16.23310 ? 145  TYR A N   1 
ATOM   1200 C CA  . TYR A  1 146 ? -7.64618  -25.01716 20.18616  1.000 14.29961 ? 145  TYR A CA  1 
ATOM   1201 C C   . TYR A  1 146 ? -8.17460  -25.95336 19.09061  1.000 18.57321 ? 145  TYR A C   1 
ATOM   1202 O O   . TYR A  1 146 ? -7.38243  -26.51695 18.33411  1.000 18.39716 ? 145  TYR A O   1 
ATOM   1203 C CB  . TYR A  1 146 ? -7.54652  -23.59789 19.59238  1.000 17.79670 ? 145  TYR A CB  1 
ATOM   1204 C CG  . TYR A  1 146 ? -6.86849  -22.60316 20.49548  1.000 17.37496 ? 145  TYR A CG  1 
ATOM   1205 C CD1 . TYR A  1 146 ? -5.48567  -22.51240 20.54280  1.000 18.13050 ? 145  TYR A CD1 1 
ATOM   1206 C CD2 . TYR A  1 146 ? -7.61735  -21.76461 21.30861  1.000 18.22932 ? 145  TYR A CD2 1 
ATOM   1207 C CE1 . TYR A  1 146 ? -4.85827  -21.62012 21.40584  1.000 17.46633 ? 145  TYR A CE1 1 
ATOM   1208 C CE2 . TYR A  1 146 ? -7.00313  -20.85645 22.15558  1.000 16.78264 ? 145  TYR A CE2 1 
ATOM   1209 C CZ  . TYR A  1 146 ? -5.62372  -20.78333 22.18633  1.000 20.07611 ? 145  TYR A CZ  1 
ATOM   1210 O OH  . TYR A  1 146 ? -5.01144  -19.88213 23.02689  1.000 18.11823 ? 145  TYR A OH  1 
ATOM   1211 N N   . PRO A  1 147 ? -9.49038  -26.07586 18.93442  1.000 15.96848 ? 146  PRO A N   1 
ATOM   1212 C CA  . PRO A  1 147 ? -10.00704 -26.83209 17.77550  1.000 15.43293 ? 146  PRO A CA  1 
ATOM   1213 C C   . PRO A  1 147 ? -9.54828  -26.20151 16.46615  1.000 18.99229 ? 146  PRO A C   1 
ATOM   1214 O O   . PRO A  1 147 ? -9.53321  -24.97657 16.32105  1.000 17.97237 ? 146  PRO A O   1 
ATOM   1215 C CB  . PRO A  1 147 ? -11.52952 -26.73620 17.93382  1.000 19.32542 ? 146  PRO A CB  1 
ATOM   1216 C CG  . PRO A  1 147 ? -11.74046 -25.50555 18.79870  1.000 17.14409 ? 146  PRO A CG  1 
ATOM   1217 C CD  . PRO A  1 147 ? -10.57190 -25.49890 19.74870  1.000 15.83942 ? 146  PRO A CD  1 
ATOM   1218 N N   A GLN A  1 148 ? -9.16927  -27.05766 15.51422  0.377 17.97990 ? 147  GLN A N   1 
ATOM   1219 N N   B GLN A  1 148 ? -9.15052  -27.05001 15.51759  0.623 17.87477 ? 147  GLN A N   1 
ATOM   1220 C CA  A GLN A  1 148 ? -8.77188  -26.64565 14.17272  0.377 21.24138 ? 147  GLN A CA  1 
ATOM   1221 C CA  B GLN A  1 148 ? -8.74486  -26.56568 14.20738  0.623 21.11518 ? 147  GLN A CA  1 
ATOM   1222 C C   A GLN A  1 148 ? -9.90569  -26.92390 13.19883  0.377 25.52723 ? 147  GLN A C   1 
ATOM   1223 C C   B GLN A  1 148 ? -9.98427  -26.27407 13.37640  0.623 24.35745 ? 147  GLN A C   1 
ATOM   1224 O O   A GLN A  1 148 ? -10.55053 -27.97463 13.27792  0.377 18.92523 ? 147  GLN A O   1 
ATOM   1225 O O   B GLN A  1 148 ? -11.09619 -26.67327 13.72460  0.623 21.81267 ? 147  GLN A O   1 
ATOM   1226 C CB  A GLN A  1 148 ? -7.51849  -27.38588 13.69673  0.377 21.33819 ? 147  GLN A CB  1 
ATOM   1227 C CB  B GLN A  1 148 ? -7.86608  -27.58954 13.48504  0.623 22.43243 ? 147  GLN A CB  1 
ATOM   1228 C CG  A GLN A  1 148 ? -6.33063  -27.34983 14.62788  0.377 25.84523 ? 147  GLN A CG  1 
ATOM   1229 C CG  B GLN A  1 148 ? -6.64295  -28.03776 14.24583  0.623 21.60468 ? 147  GLN A CG  1 
ATOM   1230 C CD  A GLN A  1 148 ? -5.09196  -26.80464 13.94312  0.377 28.45451 ? 147  GLN A CD  1 
ATOM   1231 C CD  B GLN A  1 148 ? -5.40872  -27.27940 13.83682  0.623 28.89127 ? 147  GLN A CD  1 
ATOM   1232 O OE1 A GLN A  1 148 ? -5.18055  -25.91384 13.09565  0.377 32.52629 ? 147  GLN A OE1 1 
ATOM   1233 O OE1 B GLN A  1 148 ? -5.50086  -26.20839 13.23366  0.623 30.27340 ? 147  GLN A OE1 1 
ATOM   1234 N NE2 A GLN A  1 148 ? -3.93154  -27.34274 14.29873  0.377 30.99338 ? 147  GLN A NE2 1 
ATOM   1235 N NE2 B GLN A  1 148 ? -4.24163  -27.81920 14.17020  0.623 34.90269 ? 147  GLN A NE2 1 
ATOM   1236 N N   A ALA A  1 149 ? -10.07704 -26.00595 12.23859  0.377 26.32630 ? 148  ALA A N   1 
ATOM   1237 N N   B ALA A  1 149 ? -9.78124  -25.60590 12.23583  0.623 28.42601 ? 148  ALA A N   1 
ATOM   1238 C CA  A ALA A  1 149 ? -11.23895 -25.86466 11.35992  0.377 27.47523 ? 148  ALA A CA  1 
ATOM   1239 C CA  B ALA A  1 149 ? -10.92362 -25.19014 11.42805  0.623 27.88945 ? 148  ALA A CA  1 
ATOM   1240 C C   A ALA A  1 149 ? -12.05045 -27.14145 11.17779  0.377 26.35877 ? 148  ALA A C   1 
ATOM   1241 C C   B ALA A  1 149 ? -11.80974 -26.37313 11.05534  0.623 27.52664 ? 148  ALA A C   1 
ATOM   1242 O O   A ALA A  1 149 ? -13.25625 -27.15056 11.43436  0.377 20.64554 ? 148  ALA A O   1 
ATOM   1243 O O   B ALA A  1 149 ? -13.03867 -26.23836 11.03246  0.623 24.38740 ? 148  ALA A O   1 
ATOM   1244 C CB  A ALA A  1 149 ? -10.79454 -25.33602 9.99216   0.377 33.04153 ? 148  ALA A CB  1 
ATOM   1245 C CB  B ALA A  1 149 ? -10.44859 -24.45045 10.17687  0.623 27.20376 ? 148  ALA A CB  1 
ATOM   1246 N N   A ALA A  1 150 ? -11.39853 -28.22769 10.75887  0.377 24.01503 ? 149  ALA A N   1 
ATOM   1247 N N   B ALA A  1 150 ? -11.21171 -27.54684 10.81553  0.623 22.33821 ? 149  ALA A N   1 
ATOM   1248 C CA  A ALA A  1 150 ? -12.10206 -29.49005 10.55575  0.377 22.18783 ? 149  ALA A CA  1 
ATOM   1249 C CA  B ALA A  1 150 ? -11.97284 -28.72229 10.40738  0.623 25.36230 ? 149  ALA A CA  1 
ATOM   1250 C C   A ALA A  1 150 ? -12.82472 -29.96841 11.80784  0.377 31.33398 ? 149  ALA A C   1 
ATOM   1251 C C   B ALA A  1 150 ? -12.74805 -29.38878 11.53906  0.623 27.56451 ? 149  ALA A C   1 
ATOM   1252 O O   A ALA A  1 150 ? -13.73168 -30.80229 11.71001  0.377 31.20293 ? 149  ALA A O   1 
ATOM   1253 O O   B ALA A  1 150 ? -13.69152 -30.13311 11.24444  0.623 23.45276 ? 149  ALA A O   1 
ATOM   1254 C CB  A ALA A  1 150 ? -11.11977 -30.55949 10.07814  0.377 33.41799 ? 149  ALA A CB  1 
ATOM   1255 C CB  B ALA A  1 150 ? -11.04344 -29.75249 9.76043   0.623 29.23499 ? 149  ALA A CB  1 
ATOM   1256 N N   A GLU A  1 151 ? -12.44865 -29.45630 12.97613  0.377 23.00778 ? 150  GLU A N   1 
ATOM   1257 N N   B GLU A  1 151 ? -12.36200 -29.16035 12.81051  0.623 24.70295 ? 150  GLU A N   1 
ATOM   1258 C CA  A GLU A  1 151 ? -13.05288 -29.82208 14.24552  0.377 22.73203 ? 150  GLU A CA  1 
ATOM   1259 C CA  B GLU A  1 151 ? -12.97231 -29.73755 14.01364  0.623 23.52404 ? 150  GLU A CA  1 
ATOM   1260 C C   A GLU A  1 151 ? -14.03669 -28.77969 14.75747  0.377 18.26496 ? 150  GLU A C   1 
ATOM   1261 C C   B GLU A  1 151 ? -14.03959 -28.83801 14.62015  0.623 17.84028 ? 150  GLU A C   1 
ATOM   1262 O O   A GLU A  1 151 ? -14.66312 -29.01024 15.79929  0.377 19.47647 ? 150  GLU A O   1 
ATOM   1263 O O   B GLU A  1 151 ? -14.70231 -29.23068 15.58995  0.623 20.38730 ? 150  GLU A O   1 
ATOM   1264 C CB  A GLU A  1 151 ? -11.94930 -30.05591 15.29072  0.377 20.92625 ? 150  GLU A CB  1 
ATOM   1265 C CB  B GLU A  1 151 ? -11.89399 -30.00034 15.08395  0.623 21.96060 ? 150  GLU A CB  1 
ATOM   1266 C CG  A GLU A  1 151 ? -10.92870 -31.10206 14.84080  0.377 22.15001 ? 150  GLU A CG  1 
ATOM   1267 C CG  B GLU A  1 151 ? -10.85075 -31.01891 14.64091  0.623 22.42877 ? 150  GLU A CG  1 
ATOM   1268 C CD  A GLU A  1 151 ? -9.51475  -30.83790 15.32384  0.377 23.78144 ? 150  GLU A CD  1 
ATOM   1269 C CD  B GLU A  1 151 ? -9.44704  -30.74875 15.15281  0.623 24.40719 ? 150  GLU A CD  1 
ATOM   1270 O OE1 A GLU A  1 151 ? -9.28402  -29.83615 16.04001  0.377 18.88113 ? 150  GLU A OE1 1 
ATOM   1271 O OE1 B GLU A  1 151 ? -9.23355  -29.81128 15.96461  0.623 18.79403 ? 150  GLU A OE1 1 
ATOM   1272 O OE2 A GLU A  1 151 ? -8.62182  -31.63664 14.96263  0.377 21.63489 ? 150  GLU A OE2 1 
ATOM   1273 O OE2 B GLU A  1 151 ? -8.53875  -31.47905 14.70090  0.623 20.68186 ? 150  GLU A OE2 1 
ATOM   1274 N N   . VAL A  1 152 ? -14.18849 -27.63905 14.07075  1.000 18.00201 ? 151  VAL A N   1 
ATOM   1275 C CA  . VAL A  1 152 ? -14.99669 -26.57900 14.66328  1.000 18.80618 ? 151  VAL A CA  1 
ATOM   1276 C C   . VAL A  1 152 ? -16.47255 -26.95114 14.65839  1.000 20.82633 ? 151  VAL A C   1 
ATOM   1277 O O   . VAL A  1 152 ? -17.18541 -26.71376 15.64104  1.000 16.65173 ? 151  VAL A O   1 
ATOM   1278 C CB  . VAL A  1 152 ? -14.72173 -25.24919 13.93433  1.000 17.70431 ? 151  VAL A CB  1 
ATOM   1279 C CG1 . VAL A  1 152 ? -15.70217 -24.17252 14.35527  1.000 17.44433 ? 151  VAL A CG1 1 
ATOM   1280 C CG2 . VAL A  1 152 ? -13.31124 -24.79104 14.23360  1.000 23.38291 ? 151  VAL A CG2 1 
ATOM   1281 N N   . ASP A  1 153 ? -16.96117 -27.55294 13.56960  1.000 19.00913 ? 152  ASP A N   1 
ATOM   1282 C CA  . ASP A  1 153 ? -18.37595 -27.92123 13.54355  1.000 16.99447 ? 152  ASP A CA  1 
ATOM   1283 C C   . ASP A  1 153 ? -18.70845 -28.92561 14.64095  1.000 17.68254 ? 152  ASP A C   1 
ATOM   1284 O O   . ASP A  1 153 ? -19.77825 -28.85052 15.25185  1.000 17.28060 ? 152  ASP A O   1 
ATOM   1285 C CB  . ASP A  1 153 ? -18.75139 -28.49195 12.17344  1.000 17.33763 ? 152  ASP A CB  1 
ATOM   1286 C CG  . ASP A  1 153 ? -18.89272 -27.42842 11.11103  1.000 22.79718 ? 152  ASP A CG  1 
ATOM   1287 O OD1 . ASP A  1 153 ? -18.92432 -26.21396 11.42392  1.000 19.57669 ? 152  ASP A OD1 1 
ATOM   1288 O OD2 . ASP A  1 153 ? -18.98198 -27.81853 9.92378   1.000 23.01936 ? 152  ASP A OD2 1 
ATOM   1289 N N   . GLY A  1 154 ? -17.81975 -29.88976 14.89208  1.000 16.66879 ? 153  GLY A N   1 
ATOM   1290 C CA  . GLY A  1 154 ? -18.05972 -30.82026 15.98015  1.000 16.22038 ? 153  GLY A CA  1 
ATOM   1291 C C   . GLY A  1 154 ? -18.02621 -30.12320 17.32578  1.000 17.17032 ? 153  GLY A C   1 
ATOM   1292 O O   . GLY A  1 154 ? -18.86411 -30.38328 18.19488  1.000 15.85599 ? 153  GLY A O   1 
ATOM   1293 N N   . PHE A  1 155 ? -17.05797 -29.22354 17.50427  1.000 16.76154 ? 154  PHE A N   1 
ATOM   1294 C CA  . PHE A  1 155 ? -16.93519 -28.43968 18.73754  1.000 19.17468 ? 154  PHE A CA  1 
ATOM   1295 C C   . PHE A  1 155 ? -18.20828 -27.64470 19.00692  1.000 15.09537 ? 154  PHE A C   1 
ATOM   1296 O O   . PHE A  1 155 ? -18.74180 -27.64483 20.12962  1.000 16.52724 ? 154  PHE A O   1 
ATOM   1297 C CB  . PHE A  1 155 ? -15.71821 -27.52164 18.57618  1.000 17.08469 ? 154  PHE A CB  1 
ATOM   1298 C CG  . PHE A  1 155 ? -15.41936 -26.63164 19.75596  1.000 18.18807 ? 154  PHE A CG  1 
ATOM   1299 C CD1 . PHE A  1 155 ? -14.99890 -27.15467 20.95099  1.000 19.38499 ? 154  PHE A CD1 1 
ATOM   1300 C CD2 . PHE A  1 155 ? -15.47487 -25.25213 19.60539  1.000 21.34284 ? 154  PHE A CD2 1 
ATOM   1301 C CE1 . PHE A  1 155 ? -14.67521 -26.30726 22.02475  1.000 22.19730 ? 154  PHE A CE1 1 
ATOM   1302 C CE2 . PHE A  1 155 ? -15.15432 -24.40245 20.65366  1.000 22.91033 ? 154  PHE A CE2 1 
ATOM   1303 C CZ  . PHE A  1 155 ? -14.74760 -24.93290 21.85947  1.000 17.79849 ? 154  PHE A CZ  1 
ATOM   1304 N N   . ILE A  1 156 ? -18.71125 -26.96904 17.97180  1.000 15.67549 ? 155  ILE A N   1 
ATOM   1305 C CA  . ILE A  1 156 ? -19.95142 -26.20122 18.07404  1.000 15.48371 ? 155  ILE A CA  1 
ATOM   1306 C C   . ILE A  1 156 ? -21.09975 -27.09619 18.51666  1.000 17.84331 ? 155  ILE A C   1 
ATOM   1307 O O   . ILE A  1 156 ? -21.84657 -26.76380 19.44313  1.000 15.60364 ? 155  ILE A O   1 
ATOM   1308 C CB  . ILE A  1 156 ? -20.26434 -25.51915 16.72912  1.000 14.10566 ? 155  ILE A CB  1 
ATOM   1309 C CG1 . ILE A  1 156 ? -19.30188 -24.35626 16.49765  1.000 14.56571 ? 155  ILE A CG1 1 
ATOM   1310 C CG2 . ILE A  1 156 ? -21.71793 -25.03541 16.70831  1.000 16.42127 ? 155  ILE A CG2 1 
ATOM   1311 C CD1 . ILE A  1 156 ? -19.26511 -23.86419 15.02337  1.000 16.11450 ? 155  ILE A CD1 1 
ATOM   1312 N N   . ALA A  1 157 ? -21.26088 -28.24581 17.85763  1.000 16.12389 ? 156  ALA A N   1 
ATOM   1313 C CA  . ALA A  1 157 ? -22.34989 -29.14914 18.21643  1.000 16.90288 ? 156  ALA A CA  1 
ATOM   1314 C C   . ALA A  1 157 ? -22.18908 -29.68894 19.63066  1.000 17.64637 ? 156  ALA A C   1 
ATOM   1315 O O   . ALA A  1 157 ? -23.18675 -29.92851 20.32023  1.000 16.38457 ? 156  ALA A O   1 
ATOM   1316 C CB  . ALA A  1 157 ? -22.43369 -30.29960 17.20552  1.000 17.27016 ? 156  ALA A CB  1 
ATOM   1317 N N   . ALA A  1 158 ? -20.94748 -29.90836 20.07543  1.000 14.88455 ? 157  ALA A N   1 
ATOM   1318 C CA  . ALA A  1 158 ? -20.72462 -30.36398 21.44257  1.000 16.93401 ? 157  ALA A CA  1 
ATOM   1319 C C   . ALA A  1 158 ? -21.16420 -29.31065 22.44716  1.000 15.59948 ? 157  ALA A C   1 
ATOM   1320 O O   . ALA A  1 158 ? -21.82683 -29.63339 23.43901  1.000 15.98841 ? 157  ALA A O   1 
ATOM   1321 C CB  . ALA A  1 158 ? -19.25133 -30.70938 21.65005  1.000 15.50227 ? 157  ALA A CB  1 
ATOM   1322 N N   . LEU A  1 159 ? -20.80941 -28.04636 22.20101  1.000 15.06666 ? 158  LEU A N   1 
ATOM   1323 C CA  . LEU A  1 159 ? -21.25324 -26.96464 23.07718  1.000 15.09028 ? 158  LEU A CA  1 
ATOM   1324 C C   . LEU A  1 159 ? -22.77221 -26.86234 23.09795  1.000 15.34083 ? 158  LEU A C   1 
ATOM   1325 O O   . LEU A  1 159 ? -23.37508 -26.69113 24.16607  1.000 15.77179 ? 158  LEU A O   1 
ATOM   1326 C CB  . LEU A  1 159 ? -20.64280 -25.63893 22.62826  1.000 14.95664 ? 158  LEU A CB  1 
ATOM   1327 C CG  . LEU A  1 159 ? -19.11887 -25.53653 22.71721  1.000 15.18648 ? 158  LEU A CG  1 
ATOM   1328 C CD1 . LEU A  1 159 ? -18.66832 -24.23625 22.09481  1.000 15.60785 ? 158  LEU A CD1 1 
ATOM   1329 C CD2 . LEU A  1 159 ? -18.68566 -25.61901 24.18790  1.000 16.51722 ? 158  LEU A CD2 1 
ATOM   1330 N N   . GLN A  1 160 ? -23.40723 -26.97358 21.92707  1.000 16.73766 ? 159  GLN A N   1 
ATOM   1331 C CA  . GLN A  1 160 ? -24.86344 -26.91189 21.87096  1.000 16.14995 ? 159  GLN A CA  1 
ATOM   1332 C C   . GLN A  1 160 ? -25.48112 -28.02626 22.70029  1.000 17.81480 ? 159  GLN A C   1 
ATOM   1333 O O   . GLN A  1 160 ? -26.45176 -27.80285 23.43774  1.000 17.44997 ? 159  GLN A O   1 
ATOM   1334 C CB  . GLN A  1 160 ? -25.34055 -26.98970 20.41303  1.000 15.68210 ? 159  GLN A CB  1 
ATOM   1335 C CG  . GLN A  1 160 ? -24.99516 -25.74235 19.57952  1.000 16.03670 ? 159  GLN A CG  1 
ATOM   1336 C CD  . GLN A  1 160 ? -25.14102 -25.97112 18.08613  1.000 17.69155 ? 159  GLN A CD  1 
ATOM   1337 O OE1 . GLN A  1 160 ? -25.24085 -27.10886 17.63208  1.000 17.68788 ? 159  GLN A OE1 1 
ATOM   1338 N NE2 . GLN A  1 160 ? -25.14126 -24.89052 17.31616  1.000 17.55956 ? 159  GLN A NE2 1 
ATOM   1339 N N   . GLU A  1 161 ? -24.90932 -29.22703 22.62194  1.000 13.90026 ? 160  GLU A N   1 
ATOM   1340 C CA  . GLU A  1 161 ? -25.47368 -30.35499 23.34890  1.000 14.68794 ? 160  GLU A CA  1 
ATOM   1341 C C   . GLU A  1 161 ? -25.26671 -30.20804 24.85604  1.000 17.71780 ? 160  GLU A C   1 
ATOM   1342 O O   . GLU A  1 161 ? -26.18829 -30.47124 25.62722  1.000 16.49494 ? 160  GLU A O   1 
ATOM   1343 C CB  . GLU A  1 161 ? -24.88163 -31.66835 22.83779  1.000 17.90661 ? 160  GLU A CB  1 
ATOM   1344 C CG  . GLU A  1 161 ? -25.50500 -32.89626 23.50012  1.000 19.46160 ? 160  GLU A CG  1 
ATOM   1345 C CD  . GLU A  1 161 ? -25.75569 -34.04842 22.54558  1.000 20.27443 ? 160  GLU A CD  1 
ATOM   1346 O OE1 . GLU A  1 161 ? -25.30816 -33.97067 21.38989  1.000 28.35062 ? 160  GLU A OE1 1 
ATOM   1347 O OE2 . GLU A  1 161 ? -26.37969 -35.04654 22.96604  1.000 18.61618 ? 160  GLU A OE2 1 
ATOM   1348 N N   . ILE A  1 162 ? -24.07874 -29.77245 25.29263  1.000 15.13210 ? 161  ILE A N   1 
ATOM   1349 C CA  . ILE A  1 162 ? -23.86807 -29.48598 26.71323  1.000 15.82244 ? 161  ILE A CA  1 
ATOM   1350 C C   . ILE A  1 162 ? -24.86374 -28.44222 27.20487  1.000 18.09495 ? 161  ILE A C   1 
ATOM   1351 O O   . ILE A  1 162 ? -25.46629 -28.59406 28.27696  1.000 17.43840 ? 161  ILE A O   1 
ATOM   1352 C CB  . ILE A  1 162 ? -22.41660 -29.03676 26.96315  1.000 15.22457 ? 161  ILE A CB  1 
ATOM   1353 C CG1 . ILE A  1 162 ? -21.45730 -30.19661 26.66064  1.000 17.15529 ? 161  ILE A CG1 1 
ATOM   1354 C CG2 . ILE A  1 162 ? -22.25878 -28.54260 28.41224  1.000 15.34193 ? 161  ILE A CG2 1 
ATOM   1355 C CD1 . ILE A  1 162 ? -19.99990 -29.76610 26.55043  1.000 18.93454 ? 161  ILE A CD1 1 
ATOM   1356 N N   . ARG A  1 163 ? -25.05186 -27.36626 26.43122  1.000 15.51442 ? 162  ARG A N   1 
ATOM   1357 C CA  . ARG A  1 163 ? -26.00126 -26.32557 26.82118  1.000 17.06163 ? 162  ARG A CA  1 
ATOM   1358 C C   . ARG A  1 163 ? -27.39045 -26.90672 27.08645  1.000 17.48743 ? 162  ARG A C   1 
ATOM   1359 O O   . ARG A  1 163 ? -28.01147 -26.61948 28.11599  1.000 17.52925 ? 162  ARG A O   1 
ATOM   1360 C CB  . ARG A  1 163 ? -26.06103 -25.24821 25.73478  1.000 16.72863 ? 162  ARG A CB  1 
ATOM   1361 C CG  . ARG A  1 163 ? -27.29987 -24.34847 25.77360  1.000 16.59379 ? 162  ARG A CG  1 
ATOM   1362 C CD  . ARG A  1 163 ? -27.44979 -23.61979 27.13322  1.000 14.95808 ? 162  ARG A CD  1 
ATOM   1363 N NE  . ARG A  1 163 ? -26.28231 -22.80420 27.43348  1.000 17.34039 ? 162  ARG A NE  1 
ATOM   1364 C CZ  . ARG A  1 163 ? -26.12382 -22.13554 28.56615  1.000 19.82226 ? 162  ARG A CZ  1 
ATOM   1365 N NH1 . ARG A  1 163 ? -27.01514 -22.21729 29.54523  1.000 18.41459 ? 162  ARG A NH1 1 
ATOM   1366 N NH2 . ARG A  1 163 ? -25.05800 -21.35264 28.71201  1.000 17.96922 ? 162  ARG A NH2 1 
ATOM   1367 N N   . THR A  1 164 ? -27.89403 -27.74436 26.17504  1.000 15.29805 ? 163  THR A N   1 
ATOM   1368 C CA  . THR A  1 164 ? -29.22339 -28.31362 26.39437  1.000 14.19159 ? 163  THR A CA  1 
ATOM   1369 C C   . THR A  1 164 ? -29.27163 -29.12979 27.67971  1.000 15.97797 ? 163  THR A C   1 
ATOM   1370 O O   . THR A  1 164 ? -30.22455 -29.01458 28.46831  1.000 16.28314 ? 163  THR A O   1 
ATOM   1371 C CB  . THR A  1 164 ? -29.63104 -29.15700 25.18943  1.000 16.63151 ? 163  THR A CB  1 
ATOM   1372 O OG1 . THR A  1 164 ? -29.64038 -28.31287 24.03684  1.000 18.84654 ? 163  THR A OG1 1 
ATOM   1373 C CG2 . THR A  1 164 ? -31.03386 -29.71964 25.41474  1.000 18.72988 ? 163  THR A CG2 1 
ATOM   1374 N N   . LEU A  1 165 ? -28.23052 -29.92891 27.93653  1.000 15.76184 ? 164  LEU A N   1 
ATOM   1375 C CA  . LEU A  1 165 ? -28.22132 -30.76001 29.13651  1.000 15.92764 ? 164  LEU A CA  1 
ATOM   1376 C C   . LEU A  1 165 ? -28.09391 -29.91066 30.39923  1.000 19.60877 ? 164  LEU A C   1 
ATOM   1377 O O   . LEU A  1 165 ? -28.72342 -30.21229 31.42195  1.000 19.95295 ? 164  LEU A O   1 
ATOM   1378 C CB  . LEU A  1 165 ? -27.09469 -31.79159 29.05411  1.000 15.17353 ? 164  LEU A CB  1 
ATOM   1379 C CG  . LEU A  1 165 ? -27.24492 -32.83819 27.94261  1.000 17.97650 ? 164  LEU A CG  1 
ATOM   1380 C CD1 . LEU A  1 165 ? -26.14727 -33.88533 28.06598  1.000 20.29896 ? 164  LEU A CD1 1 
ATOM   1381 C CD2 . LEU A  1 165 ? -28.62121 -33.49507 27.98054  1.000 17.06292 ? 164  LEU A CD2 1 
ATOM   1382 N N   . LEU A  1 166 ? -27.30170 -28.83406 30.34242  1.000 16.41048 ? 165  LEU A N   1 
ATOM   1383 C CA  . LEU A  1 166 ? -27.20598 -27.93252 31.48943  1.000 16.98885 ? 165  LEU A CA  1 
ATOM   1384 C C   . LEU A  1 166 ? -28.54590 -27.27484 31.78224  1.000 16.55400 ? 165  LEU A C   1 
ATOM   1385 O O   . LEU A  1 166 ? -28.92822 -27.11613 32.95058  1.000 17.46445 ? 165  LEU A O   1 
ATOM   1386 C CB  . LEU A  1 166 ? -26.14533 -26.86093 31.22861  1.000 16.31135 ? 165  LEU A CB  1 
ATOM   1387 C CG  . LEU A  1 166 ? -24.68752 -27.33409 31.28821  1.000 17.52280 ? 165  LEU A CG  1 
ATOM   1388 C CD1 . LEU A  1 166 ? -23.75466 -26.19294 30.87747  1.000 18.51355 ? 165  LEU A CD1 1 
ATOM   1389 C CD2 . LEU A  1 166 ? -24.30997 -27.86160 32.65991  1.000 22.44043 ? 165  LEU A CD2 1 
ATOM   1390 N N   . ASN A  1 167 ? -29.26663 -26.86886 30.73167  1.000 16.67947 ? 166  ASN A N   1 
ATOM   1391 C CA  . ASN A  1 167 ? -30.57498 -26.25165 30.92879  1.000 17.85756 ? 166  ASN A CA  1 
ATOM   1392 C C   . ASN A  1 167 ? -31.56173 -27.23920 31.53676  1.000 20.45089 ? 166  ASN A C   1 
ATOM   1393 O O   . ASN A  1 167 ? -32.37107 -26.86390 32.39489  1.000 18.33531 ? 166  ASN A O   1 
ATOM   1394 C CB  . ASN A  1 167 ? -31.11459 -25.69450 29.60462  1.000 16.81437 ? 166  ASN A CB  1 
ATOM   1395 C CG  . ASN A  1 167 ? -30.39394 -24.42675 29.15361  1.000 17.98310 ? 166  ASN A CG  1 
ATOM   1396 O OD1 . ASN A  1 167 ? -29.52019 -23.90794 29.84544  1.000 18.97693 ? 166  ASN A OD1 1 
ATOM   1397 N ND2 . ASN A  1 167 ? -30.76744 -23.92102 27.97864  1.000 18.36853 ? 166  ASN A ND2 1 
ATOM   1398 N N   . GLN A  1 168 ? -31.51877 -28.50601 31.10611  1.000 19.08999 ? 167  GLN A N   1 
ATOM   1399 C CA  . GLN A  1 168 ? -32.32066 -29.53224 31.77471  1.000 15.96469 ? 167  GLN A CA  1 
ATOM   1400 C C   . GLN A  1 168 ? -31.96930 -29.61097 33.24852  1.000 19.33517 ? 167  GLN A C   1 
ATOM   1401 O O   . GLN A  1 168 ? -32.85270 -29.71419 34.10891  1.000 20.61182 ? 167  GLN A O   1 
ATOM   1402 C CB  . GLN A  1 168 ? -32.09248 -30.90082 31.13767  1.000 17.71133 ? 167  GLN A CB  1 
ATOM   1403 C CG  . GLN A  1 168 ? -32.65560 -31.02999 29.74206  1.000 17.37861 ? 167  GLN A CG  1 
ATOM   1404 C CD  . GLN A  1 168 ? -32.36676 -32.39942 29.14567  1.000 20.00609 ? 167  GLN A CD  1 
ATOM   1405 O OE1 . GLN A  1 168 ? -31.90396 -33.31108 29.83236  1.000 21.34060 ? 167  GLN A OE1 1 
ATOM   1406 N NE2 . GLN A  1 168 ? -32.64903 -32.54708 27.86190  1.000 19.98644 ? 167  GLN A NE2 1 
ATOM   1407 N N   . GLN A  1 169 ? -30.66973 -29.60109 33.55136  1.000 16.14587 ? 168  GLN A N   1 
ATOM   1408 C CA  . GLN A  1 169 ? -30.23555 -29.72458 34.93557  1.000 17.38062 ? 168  GLN A CA  1 
ATOM   1409 C C   . GLN A  1 169 ? -30.68619 -28.52979 35.76418  1.000 19.77754 ? 168  GLN A C   1 
ATOM   1410 O O   . GLN A  1 169 ? -31.04885 -28.68217 36.94027  1.000 21.17143 ? 168  GLN A O   1 
ATOM   1411 C CB  . GLN A  1 169 ? -28.71442 -29.87610 34.99300  1.000 19.59161 ? 168  GLN A CB  1 
ATOM   1412 C CG  . GLN A  1 169 ? -28.24364 -30.51240 36.30247  1.000 22.17936 ? 168  GLN A CG  1 
ATOM   1413 C CD  . GLN A  1 169 ? -28.85093 -31.89059 36.51658  1.000 23.57895 ? 168  GLN A CD  1 
ATOM   1414 O OE1 . GLN A  1 169 ? -28.82596 -32.73936 35.62024  1.000 23.83548 ? 168  GLN A OE1 1 
ATOM   1415 N NE2 . GLN A  1 169 ? -29.40042 -32.11960 37.70523  1.000 25.01205 ? 168  GLN A NE2 1 
ATOM   1416 N N   . THR A  1 170 ? -30.65771 -27.33124 35.17585  1.000 17.77846 ? 169  THR A N   1 
ATOM   1417 C CA  . THR A  1 170 ? -31.13515 -26.14505 35.88414  1.000 19.51906 ? 169  THR A CA  1 
ATOM   1418 C C   . THR A  1 170 ? -32.59832 -26.29901 36.28257  1.000 22.77365 ? 169  THR A C   1 
ATOM   1419 O O   . THR A  1 170 ? -32.98771 -25.94178 37.39933  1.000 21.12766 ? 169  THR A O   1 
ATOM   1420 C CB  . THR A  1 170 ? -30.94990 -24.90320 35.01467  1.000 22.97386 ? 169  THR A CB  1 
ATOM   1421 O OG1 . THR A  1 170 ? -29.55235 -24.58575 34.91539  1.000 19.20691 ? 169  THR A OG1 1 
ATOM   1422 C CG2 . THR A  1 170 ? -31.70593 -23.71300 35.60091  1.000 17.83480 ? 169  THR A CG2 1 
ATOM   1423 N N   . ILE A  1 171 ? -33.42500 -26.81387 35.37532  1.000 21.07126 ? 170  ILE A N   1 
ATOM   1424 C CA  . ILE A  1 171 ? -34.82622 -27.06287 35.70458  1.000 17.80862 ? 170  ILE A CA  1 
ATOM   1425 C C   . ILE A  1 171 ? -34.93258 -28.13871 36.78122  1.000 22.16764 ? 170  ILE A C   1 
ATOM   1426 O O   . ILE A  1 171 ? -35.67037 -27.99243 37.76674  1.000 22.18964 ? 170  ILE A O   1 
ATOM   1427 C CB  . ILE A  1 171 ? -35.60945 -27.44878 34.43593  1.000 21.68430 ? 170  ILE A CB  1 
ATOM   1428 C CG1 . ILE A  1 171 ? -35.85244 -26.22110 33.56671  1.000 21.67084 ? 170  ILE A CG1 1 
ATOM   1429 C CG2 . ILE A  1 171 ? -36.94099 -28.12424 34.81282  1.000 20.94323 ? 170  ILE A CG2 1 
ATOM   1430 C CD1 . ILE A  1 171 ? -36.16482 -26.54637 32.10083  1.000 23.50410 ? 170  ILE A CD1 1 
ATOM   1431 N N   . ALA A  1 172 ? -34.18267 -29.23078 36.62111  1.000 19.51801 ? 171  ALA A N   1 
ATOM   1432 C CA  . ALA A  1 172 ? -34.31403 -30.34687 37.54468  1.000 20.68127 ? 171  ALA A CA  1 
ATOM   1433 C C   . ALA A  1 172 ? -33.94794 -29.93608 38.96431  1.000 27.96443 ? 171  ALA A C   1 
ATOM   1434 O O   . ALA A  1 172 ? -34.54913 -30.42496 39.92751  1.000 24.83539 ? 171  ALA A O   1 
ATOM   1435 C CB  . ALA A  1 172 ? -33.43995 -31.51532 37.09165  1.000 23.67207 ? 171  ALA A CB  1 
ATOM   1436 N N   . ASP A  1 173 ? -32.98296 -29.03318 39.11473  1.000 21.04159 ? 172  ASP A N   1 
ATOM   1437 C CA  . ASP A  1 173 ? -32.51895 -28.60721 40.42984  1.000 21.14065 ? 172  ASP A CA  1 
ATOM   1438 C C   . ASP A  1 173 ? -33.13875 -27.29927 40.89766  1.000 24.66860 ? 172  ASP A C   1 
ATOM   1439 O O   . ASP A  1 173 ? -32.75506 -26.80150 41.96348  1.000 24.73193 ? 172  ASP A O   1 
ATOM   1440 C CB  . ASP A  1 173 ? -30.99615 -28.48768 40.43238  1.000 20.95071 ? 172  ASP A CB  1 
ATOM   1441 C CG  . ASP A  1 173 ? -30.31259 -29.81547 40.21848  1.000 25.95632 ? 172  ASP A CG  1 
ATOM   1442 O OD1 . ASP A  1 173 ? -30.94753 -30.85553 40.48842  1.000 28.18380 ? 172  ASP A OD1 1 
ATOM   1443 O OD2 . ASP A  1 173 ? -29.14148 -29.82822 39.77829  1.000 24.29168 ? 172  ASP A OD2 1 
ATOM   1444 N N   . GLY A  1 174 ? -34.09411 -26.74958 40.15426  1.000 22.55200 ? 173  GLY A N   1 
ATOM   1445 C CA  . GLY A  1 174 ? -34.68904 -25.46832 40.51674  1.000 22.42342 ? 173  GLY A CA  1 
ATOM   1446 C C   . GLY A  1 174 ? -33.67214 -24.35746 40.64945  1.000 26.76039 ? 173  GLY A C   1 
ATOM   1447 O O   . GLY A  1 174 ? -33.75832 -23.53978 41.57514  1.000 22.91116 ? 173  GLY A O   1 
ATOM   1448 N N   . ARG A  1 175 ? -32.70068 -24.30614 39.73626  1.000 19.88870 ? 174  ARG A N   1 
ATOM   1449 C CA  . ARG A  1 175 ? -31.55668 -23.41427 39.86937  1.000 20.97819 ? 174  ARG A CA  1 
ATOM   1450 C C   . ARG A  1 175 ? -31.71211 -22.12916 39.06703  1.000 22.86331 ? 174  ARG A C   1 
ATOM   1451 O O   . ARG A  1 175 ? -30.71454 -21.51101 38.68456  1.000 22.49539 ? 174  ARG A O   1 
ATOM   1452 C CB  . ARG A  1 175 ? -30.27936 -24.15469 39.47081  1.000 20.10503 ? 174  ARG A CB  1 
ATOM   1453 C CG  . ARG A  1 175 ? -29.67290 -24.93403 40.62992  1.000 21.74326 ? 174  ARG A CG  1 
ATOM   1454 C CD  . ARG A  1 175 ? -28.99518 -23.98434 41.61441  1.000 23.16695 ? 174  ARG A CD  1 
ATOM   1455 N NE  . ARG A  1 175 ? -27.68842 -23.55448 41.12208  1.000 20.82645 ? 174  ARG A NE  1 
ATOM   1456 C CZ  . ARG A  1 175 ? -26.55528 -24.18953 41.38417  1.000 20.81774 ? 174  ARG A CZ  1 
ATOM   1457 N NH1 . ARG A  1 175 ? -26.52229 -25.24653 42.18658  1.000 20.10085 ? 174  ARG A NH1 1 
ATOM   1458 N NH2 . ARG A  1 175 ? -25.42569 -23.75678 40.82754  1.000 20.80800 ? 174  ARG A NH2 1 
ATOM   1459 N N   . GLN A  1 176 ? -32.94746 -21.68149 38.83312  1.000 22.02670 ? 175  GLN A N   1 
ATOM   1460 C CA  . GLN A  1 176 ? -33.14898 -20.49014 38.01312  1.000 20.90626 ? 175  GLN A CA  1 
ATOM   1461 C C   . GLN A  1 176 ? -32.47383 -19.25015 38.60234  1.000 23.09692 ? 175  GLN A C   1 
ATOM   1462 O O   . GLN A  1 176 ? -32.14388 -18.31765 37.85808  1.000 26.99563 ? 175  GLN A O   1 
ATOM   1463 C CB  . GLN A  1 176 ? -34.64389 -20.23072 37.82082  1.000 25.90834 ? 175  GLN A CB  1 
ATOM   1464 C CG  . GLN A  1 176 ? -35.28641 -21.08539 36.74838  1.000 23.23185 ? 175  GLN A CG  1 
ATOM   1465 C CD  . GLN A  1 176 ? -35.58347 -22.49964 37.22632  1.000 23.43668 ? 175  GLN A CD  1 
ATOM   1466 O OE1 . GLN A  1 176 ? -35.54186 -22.79138 38.43203  1.000 24.41750 ? 175  GLN A OE1 1 
ATOM   1467 N NE2 . GLN A  1 176 ? -35.86391 -23.39581 36.27389  1.000 24.07405 ? 175  GLN A NE2 1 
ATOM   1468 N N   . ALA A  1 177 ? -32.27372 -19.20724 39.91897  1.000 24.34156 ? 176  ALA A N   1 
ATOM   1469 C CA  . ALA A  1 177 ? -31.60902 -18.05706 40.52233  1.000 29.75025 ? 176  ALA A CA  1 
ATOM   1470 C C   . ALA A  1 177 ? -30.10748 -18.05987 40.28166  1.000 31.74900 ? 176  ALA A C   1 
ATOM   1471 O O   . ALA A  1 177 ? -29.47164 -17.00574 40.37978  1.000 28.90956 ? 176  ALA A O   1 
ATOM   1472 C CB  . ALA A  1 177 ? -31.87478 -18.01103 42.02593  1.000 29.22441 ? 176  ALA A CB  1 
ATOM   1473 N N   . LEU A  1 178 ? -29.53087 -19.22296 39.98794  1.000 23.03889 ? 177  LEU A N   1 
ATOM   1474 C CA  . LEU A  1 178 ? -28.09847 -19.34703 39.71458  1.000 19.97118 ? 177  LEU A CA  1 
ATOM   1475 C C   . LEU A  1 178 ? -27.93033 -20.48228 38.71539  1.000 17.00144 ? 177  LEU A C   1 
ATOM   1476 O O   . LEU A  1 178 ? -27.44373 -21.56737 39.04835  1.000 19.94853 ? 177  LEU A O   1 
ATOM   1477 C CB  . LEU A  1 178 ? -27.32076 -19.61277 41.00519  1.000 21.00939 ? 177  LEU A CB  1 
ATOM   1478 C CG  . LEU A  1 178 ? -25.81273 -19.37463 40.89701  1.000 22.53762 ? 177  LEU A CG  1 
ATOM   1479 C CD1 . LEU A  1 178 ? -25.51786 -17.88529 40.71258  1.000 18.75398 ? 177  LEU A CD1 1 
ATOM   1480 C CD2 . LEU A  1 178 ? -25.06265 -19.96762 42.07768  1.000 24.53541 ? 177  LEU A CD2 1 
ATOM   1481 N N   . PRO A  1 179 ? -28.39266 -20.28592 37.49189  1.000 17.88945 ? 178  PRO A N   1 
ATOM   1482 C CA  . PRO A  1 179 ? -28.46251 -21.41084 36.54643  1.000 20.33576 ? 178  PRO A CA  1 
ATOM   1483 C C   . PRO A  1 179 ? -27.08061 -21.93262 36.17869  1.000 20.32265 ? 178  PRO A C   1 
ATOM   1484 O O   . PRO A  1 179 ? -26.09465 -21.19437 36.16971  1.000 18.14624 ? 178  PRO A O   1 
ATOM   1485 C CB  . PRO A  1 179 ? -29.17752 -20.81499 35.33158  1.000 22.52369 ? 178  PRO A CB  1 
ATOM   1486 C CG  . PRO A  1 179 ? -29.04435 -19.33556 35.47158  1.000 23.54361 ? 178  PRO A CG  1 
ATOM   1487 C CD  . PRO A  1 179 ? -28.90817 -19.02700 36.92851  1.000 18.39488 ? 178  PRO A CD  1 
ATOM   1488 N N   . TYR A  1 180 ? -27.01091 -23.23585 35.90393  1.000 18.21503 ? 179  TYR A N   1 
ATOM   1489 C CA  . TYR A  1 180 ? -25.74453 -23.82019 35.48320  1.000 18.52960 ? 179  TYR A CA  1 
ATOM   1490 C C   . TYR A  1 180 ? -25.26123 -23.15562 34.19935  1.000 18.26185 ? 179  TYR A C   1 
ATOM   1491 O O   . TYR A  1 180 ? -26.04771 -22.87929 33.28627  1.000 17.99306 ? 179  TYR A O   1 
ATOM   1492 C CB  . TYR A  1 180 ? -25.89012 -25.32648 35.27854  1.000 18.12863 ? 179  TYR A CB  1 
ATOM   1493 C CG  . TYR A  1 180 ? -26.28952 -26.03464 36.53717  1.000 17.89267 ? 179  TYR A CG  1 
ATOM   1494 C CD1 . TYR A  1 180 ? -25.42481 -26.08156 37.62763  1.000 16.68241 ? 179  TYR A CD1 1 
ATOM   1495 C CD2 . TYR A  1 180 ? -27.53763 -26.64037 36.65123  1.000 17.06339 ? 179  TYR A CD2 1 
ATOM   1496 C CE1 . TYR A  1 180 ? -25.79107 -26.73853 38.81210  1.000 19.26091 ? 179  TYR A CE1 1 
ATOM   1497 C CE2 . TYR A  1 180 ? -27.90596 -27.30450 37.82538  1.000 17.97503 ? 179  TYR A CE2 1 
ATOM   1498 C CZ  . TYR A  1 180 ? -27.03095 -27.34467 38.89646  1.000 20.15323 ? 179  TYR A CZ  1 
ATOM   1499 O OH  . TYR A  1 180 ? -27.39778 -27.99483 40.07022  1.000 22.38382 ? 179  TYR A OH  1 
ATOM   1500 N N   . GLN A  1 181 ? -23.95819 -22.89499 34.13159  1.000 16.50001 ? 180  GLN A N   1 
ATOM   1501 C CA  . GLN A  1 181 ? -23.40551 -22.10128 33.04530  1.000 16.92508 ? 180  GLN A CA  1 
ATOM   1502 C C   . GLN A  1 181 ? -22.41362 -22.89593 32.20442  1.000 16.19767 ? 180  GLN A C   1 
ATOM   1503 O O   . GLN A  1 181 ? -21.88145 -23.92605 32.62493  1.000 16.07237 ? 180  GLN A O   1 
ATOM   1504 C CB  . GLN A  1 181 ? -22.73482 -20.83134 33.59316  1.000 17.79963 ? 180  GLN A CB  1 
ATOM   1505 C CG  . GLN A  1 181 ? -23.74059 -19.81122 34.10099  1.000 19.17416 ? 180  GLN A CG  1 
ATOM   1506 C CD  . GLN A  1 181 ? -23.13409 -18.44918 34.34507  1.000 17.39940 ? 180  GLN A CD  1 
ATOM   1507 O OE1 . GLN A  1 181 ? -21.94456 -18.33054 34.64637  1.000 18.56592 ? 180  GLN A OE1 1 
ATOM   1508 N NE2 . GLN A  1 181 ? -23.94706 -17.40711 34.21405  1.000 17.87628 ? 180  GLN A NE2 1 
ATOM   1509 N N   . LEU A  1 182 ? -22.19883 -22.40232 30.98390  1.000 14.95000 ? 181  LEU A N   1 
ATOM   1510 C CA  . LEU A  1 182 ? -21.23889 -22.96503 30.03594  1.000 16.00616 ? 181  LEU A CA  1 
ATOM   1511 C C   . LEU A  1 182 ? -20.35565 -21.83417 29.52930  1.000 14.92687 ? 181  LEU A C   1 
ATOM   1512 O O   . LEU A  1 182 ? -20.86103 -20.83513 28.99983  1.000 15.92470 ? 181  LEU A O   1 
ATOM   1513 C CB  . LEU A  1 182 ? -21.96030 -23.65017 28.86083  1.000 15.37051 ? 181  LEU A CB  1 
ATOM   1514 C CG  . LEU A  1 182 ? -21.08749 -24.24723 27.73794  1.000 15.51902 ? 181  LEU A CG  1 
ATOM   1515 C CD1 . LEU A  1 182 ? -20.19963 -25.35537 28.31534  1.000 17.70858 ? 181  LEU A CD1 1 
ATOM   1516 C CD2 . LEU A  1 182 ? -21.96115 -24.79670 26.60363  1.000 14.71767 ? 181  LEU A CD2 1 
ATOM   1517 N N   . THR A  1 183 ? -19.03937 -21.98280 29.67678  1.000 14.67660 ? 182  THR A N   1 
ATOM   1518 C CA  . THR A  1 183 ? -18.09865 -20.98775 29.18329  1.000 13.47769 ? 182  THR A CA  1 
ATOM   1519 C C   . THR A  1 183 ? -16.98549 -21.69832 28.41707  1.000 12.43590 ? 182  THR A C   1 
ATOM   1520 O O   . THR A  1 183 ? -16.82957 -22.92369 28.50866  1.000 14.30152 ? 182  THR A O   1 
ATOM   1521 C CB  . THR A  1 183 ? -17.50577 -20.14822 30.33589  1.000 16.31026 ? 182  THR A CB  1 
ATOM   1522 O OG1 . THR A  1 183 ? -16.78362 -20.99974 31.24006  1.000 15.93647 ? 182  THR A OG1 1 
ATOM   1523 C CG2 . THR A  1 183 ? -18.61104 -19.43855 31.11532  1.000 15.56937 ? 182  THR A CG2 1 
ATOM   1524 N N   . ILE A  1 184 ? -16.21438 -20.92566 27.64400  1.000 13.15812 ? 183  ILE A N   1 
ATOM   1525 C CA  . ILE A  1 184 ? -14.94517 -21.41458 27.11191  1.000 14.90515 ? 183  ILE A CA  1 
ATOM   1526 C C   . ILE A  1 184 ? -13.86049 -20.37709 27.36768  1.000 14.49868 ? 183  ILE A C   1 
ATOM   1527 O O   . ILE A  1 184 ? -14.12636 -19.17477 27.50091  1.000 15.58896 ? 183  ILE A O   1 
ATOM   1528 C CB  . ILE A  1 184 ? -14.97870 -21.77167 25.59251  1.000 13.71486 ? 183  ILE A CB  1 
ATOM   1529 C CG1 . ILE A  1 184 ? -14.98637 -20.51600 24.71558  1.000 14.19199 ? 183  ILE A CG1 1 
ATOM   1530 C CG2 . ILE A  1 184 ? -16.15151 -22.70036 25.27834  1.000 14.70921 ? 183  ILE A CG2 1 
ATOM   1531 C CD1 . ILE A  1 184 ? -14.74168 -20.83482 23.21041  1.000 15.05883 ? 183  ILE A CD1 1 
ATOM   1532 N N   . ALA A  1 185 ? -12.62527 -20.86127 27.44859  1.000 15.78943 ? 184  ALA A N   1 
ATOM   1533 C CA  . ALA A  1 185 ? -11.45450 -20.00963 27.28509  1.000 14.88967 ? 184  ALA A CA  1 
ATOM   1534 C C   . ALA A  1 185 ? -11.18762 -19.92638 25.79096  1.000 15.88359 ? 184  ALA A C   1 
ATOM   1535 O O   . ALA A  1 185 ? -10.90097 -20.94412 25.15546  1.000 16.27487 ? 184  ALA A O   1 
ATOM   1536 C CB  . ALA A  1 185 ? -10.23618 -20.57047 28.02662  1.000 14.22335 ? 184  ALA A CB  1 
ATOM   1537 N N   . GLY A  1 186 ? -11.32015 -18.73149 25.22770  1.000 13.62341 ? 185  GLY A N   1 
ATOM   1538 C CA  . GLY A  1 186 ? -11.09309 -18.52738 23.81260  1.000 14.75429 ? 185  GLY A CA  1 
ATOM   1539 C C   . GLY A  1 186 ? -9.74402  -17.90486 23.51357  1.000 18.11946 ? 185  GLY A C   1 
ATOM   1540 O O   . GLY A  1 186 ? -9.11758  -17.27722 24.36533  1.000 15.53060 ? 185  GLY A O   1 
ATOM   1541 N N   . ALA A  1 187 ? -9.30358  -18.06800 22.26448  1.000 14.35539 ? 186  ALA A N   1 
ATOM   1542 C CA  . ALA A  1 187 ? -8.07071  -17.42373 21.83322  1.000 15.09487 ? 186  ALA A CA  1 
ATOM   1543 C C   . ALA A  1 187 ? -8.16384  -15.91404 22.02182  1.000 14.11647 ? 186  ALA A C   1 
ATOM   1544 O O   . ALA A  1 187 ? -9.20848  -15.29881 21.78325  1.000 17.56788 ? 186  ALA A O   1 
ATOM   1545 C CB  . ALA A  1 187 ? -7.77430  -17.75215 20.36121  1.000 13.97766 ? 186  ALA A CB  1 
ATOM   1546 N N   . GLY A  1 188 ? -7.06127  -15.32180 22.47370  1.000 14.06848 ? 187  GLY A N   1 
ATOM   1547 C CA  . GLY A  1 188 ? -6.93173  -13.87982 22.59264  1.000 14.77258 ? 187  GLY A CA  1 
ATOM   1548 C C   . GLY A  1 188 ? -5.98280  -13.26327 21.59190  1.000 21.19925 ? 187  GLY A C   1 
ATOM   1549 O O   . GLY A  1 188 ? -5.57824  -12.10911 21.78127  1.000 17.40563 ? 187  GLY A O   1 
ATOM   1550 N N   . GLY A  1 189 ? -5.59675  -13.99419 20.55296  1.000 16.36592 ? 188  GLY A N   1 
ATOM   1551 C CA  . GLY A  1 189 ? -4.75958  -13.46079 19.49295  1.000 13.93618 ? 188  GLY A CA  1 
ATOM   1552 C C   . GLY A  1 189 ? -5.18574  -14.07188 18.17573  1.000 16.84088 ? 188  GLY A C   1 
ATOM   1553 O O   . GLY A  1 189 ? -5.68542  -15.19623 18.12666  1.000 15.81128 ? 188  GLY A O   1 
ATOM   1554 N N   . ALA A  1 190 ? -4.95118  -13.31845 17.09490  1.000 16.18704 ? 189  ALA A N   1 
ATOM   1555 C CA  . ALA A  1 190 ? -5.58834  -13.61272 15.80733  1.000 15.87898 ? 189  ALA A CA  1 
ATOM   1556 C C   . ALA A  1 190 ? -5.12744  -14.93260 15.19136  1.000 17.49833 ? 189  ALA A C   1 
ATOM   1557 O O   . ALA A  1 190 ? -5.88489  -15.54462 14.43151  1.000 15.54196 ? 189  ALA A O   1 
ATOM   1558 C CB  . ALA A  1 190 ? -5.33048  -12.45924 14.83271  1.000 15.18396 ? 189  ALA A CB  1 
ATOM   1559 N N   . PHE A  1 191 ? -3.90276  -15.38933 15.47415  1.000 16.86458 ? 190  PHE A N   1 
ATOM   1560 C CA  . PHE A  1 191 ? -3.43862  -16.61240 14.82386  1.000 17.64485 ? 190  PHE A CA  1 
ATOM   1561 C C   . PHE A  1 191 ? -4.22821  -17.82608 15.30122  1.000 16.54807 ? 190  PHE A C   1 
ATOM   1562 O O   . PHE A  1 191 ? -4.74090  -18.60386 14.48845  1.000 17.18832 ? 190  PHE A O   1 
ATOM   1563 C CB  . PHE A  1 191 ? -1.94267  -16.80597 15.05164  1.000 17.49524 ? 190  PHE A CB  1 
ATOM   1564 C CG  . PHE A  1 191 ? -1.09236  -15.75191 14.38219  1.000 16.91751 ? 190  PHE A CG  1 
ATOM   1565 C CD1 . PHE A  1 191 ? -0.82637  -15.80944 13.01460  1.000 19.96268 ? 190  PHE A CD1 1 
ATOM   1566 C CD2 . PHE A  1 191 ? -0.58435  -14.68967 15.11711  1.000 19.77696 ? 190  PHE A CD2 1 
ATOM   1567 C CE1 . PHE A  1 191 ? -0.04430  -14.83696 12.39816  1.000 21.38841 ? 190  PHE A CE1 1 
ATOM   1568 C CE2 . PHE A  1 191 ? 0.19120   -13.71038 14.52228  1.000 18.73876 ? 190  PHE A CE2 1 
ATOM   1569 C CZ  . PHE A  1 191 ? 0.46733   -13.78162 13.14683  1.000 19.19258 ? 190  PHE A CZ  1 
ATOM   1570 N N   . PHE A  1 192 ? -4.33868  -18.01131 16.61756  1.000 15.38610 ? 191  PHE A N   1 
ATOM   1571 C CA  . PHE A  1 192 ? -5.17086  -19.10057 17.11161  1.000 15.25514 ? 191  PHE A CA  1 
ATOM   1572 C C   . PHE A  1 192 ? -6.64862  -18.83149 16.84081  1.000 15.12769 ? 191  PHE A C   1 
ATOM   1573 O O   . PHE A  1 192 ? -7.40559  -19.76043 16.54189  1.000 15.91380 ? 191  PHE A O   1 
ATOM   1574 C CB  . PHE A  1 192 ? -4.91998  -19.30819 18.60735  1.000 13.52461 ? 191  PHE A CB  1 
ATOM   1575 C CG  . PHE A  1 192 ? -3.60389  -19.97586 18.90119  1.000 15.19006 ? 191  PHE A CG  1 
ATOM   1576 C CD1 . PHE A  1 192 ? -3.29877  -21.20771 18.34389  1.000 20.31189 ? 191  PHE A CD1 1 
ATOM   1577 C CD2 . PHE A  1 192 ? -2.68218  -19.38507 19.75159  1.000 20.06778 ? 191  PHE A CD2 1 
ATOM   1578 C CE1 . PHE A  1 192 ? -2.09043  -21.84281 18.61813  1.000 24.32277 ? 191  PHE A CE1 1 
ATOM   1579 C CE2 . PHE A  1 192 ? -1.47018  -20.01440 20.02503  1.000 24.49627 ? 191  PHE A CE2 1 
ATOM   1580 C CZ  . PHE A  1 192 ? -1.17886  -21.24255 19.45805  1.000 25.16464 ? 191  PHE A CZ  1 
ATOM   1581 N N   . LEU A  1 193 ? -7.07444  -17.57044 16.96169  1.000 16.75368 ? 192  LEU A N   1 
ATOM   1582 C CA  . LEU A  1 193 ? -8.47621  -17.22444 16.74113  1.000 15.66608 ? 192  LEU A CA  1 
ATOM   1583 C C   . LEU A  1 193 ? -8.91140  -17.58199 15.32675  1.000 15.78814 ? 192  LEU A C   1 
ATOM   1584 O O   . LEU A  1 193 ? -10.05701 -17.99090 15.11018  1.000 15.95393 ? 192  LEU A O   1 
ATOM   1585 C CB  . LEU A  1 193 ? -8.67867  -15.73653 16.99973  1.000 14.88474 ? 192  LEU A CB  1 
ATOM   1586 C CG  . LEU A  1 193 ? -10.06871 -15.13336 16.77566  1.000 17.50737 ? 192  LEU A CG  1 
ATOM   1587 C CD1 . LEU A  1 193 ? -11.08321 -15.84256 17.66446  1.000 16.12855 ? 192  LEU A CD1 1 
ATOM   1588 C CD2 . LEU A  1 193 ? -10.03532 -13.63383 17.09968  1.000 17.92019 ? 192  LEU A CD2 1 
ATOM   1589 N N   . SER A  1 194 ? -7.99935  -17.46736 14.36458  1.000 15.04422 ? 193  SER A N   1 
ATOM   1590 C CA  . SER A  1 194 ? -8.35748  -17.73895 12.97455  1.000 14.15701 ? 193  SER A CA  1 
ATOM   1591 C C   . SER A  1 194 ? -8.83914  -19.17255 12.76486  1.000 15.98817 ? 193  SER A C   1 
ATOM   1592 O O   . SER A  1 194 ? -9.48539  -19.45112 11.74693  1.000 18.38758 ? 193  SER A O   1 
ATOM   1593 C CB  . SER A  1 194 ? -7.15956  -17.43750 12.07498  1.000 17.10625 ? 193  SER A CB  1 
ATOM   1594 O OG  . SER A  1 194 ? -6.15271  -18.42560 12.23587  1.000 18.26136 ? 193  SER A OG  1 
ATOM   1595 N N   . ARG A  1 195 ? -8.54512  -20.08580 13.69366  1.000 15.36578 ? 194  ARG A N   1 
ATOM   1596 C CA  . ARG A  1 195 ? -8.99294  -21.47164 13.55605  1.000 16.02856 ? 194  ARG A CA  1 
ATOM   1597 C C   . ARG A  1 195 ? -10.50885 -21.56709 13.48597  1.000 19.44761 ? 194  ARG A C   1 
ATOM   1598 O O   . ARG A  1 195 ? -11.04971 -22.34729 12.69322  1.000 19.75005 ? 194  ARG A O   1 
ATOM   1599 C CB  . ARG A  1 195 ? -8.47770  -22.32221 14.71341  1.000 16.82413 ? 194  ARG A CB  1 
ATOM   1600 C CG  . ARG A  1 195 ? -7.00325  -22.60851 14.61777  1.000 18.50391 ? 194  ARG A CG  1 
ATOM   1601 C CD  . ARG A  1 195 ? -6.48581  -23.28709 15.87006  1.000 18.50235 ? 194  ARG A CD  1 
ATOM   1602 N NE  . ARG A  1 195 ? -5.04812  -23.50511 15.75857  1.000 18.22174 ? 194  ARG A NE  1 
ATOM   1603 C CZ  . ARG A  1 195 ? -4.41512  -24.55830 16.25945  1.000 22.10839 ? 194  ARG A CZ  1 
ATOM   1604 N NH1 . ARG A  1 195 ? -5.05385  -25.48412 16.95738  1.000 19.79859 ? 194  ARG A NH1 1 
ATOM   1605 N NH2 . ARG A  1 195 ? -3.11187  -24.70144 16.02988  1.000 21.36941 ? 194  ARG A NH2 1 
ATOM   1606 N N   . TYR A  1 196 ? -11.21506 -20.78935 14.31209  1.000 17.22064 ? 195  TYR A N   1 
ATOM   1607 C CA  . TYR A  1 196 ? -12.66526 -20.90397 14.40829  1.000 16.66758 ? 195  TYR A CA  1 
ATOM   1608 C C   . TYR A  1 196 ? -13.37592 -19.57433 14.18857  1.000 17.01199 ? 195  TYR A C   1 
ATOM   1609 O O   . TYR A  1 196 ? -14.60538 -19.50936 14.32630  1.000 16.90712 ? 195  TYR A O   1 
ATOM   1610 C CB  . TYR A  1 196 ? -13.05918 -21.49699 15.76613  1.000 14.60518 ? 195  TYR A CB  1 
ATOM   1611 C CG  . TYR A  1 196 ? -12.52851 -20.74098 16.98035  1.000 16.05474 ? 195  TYR A CG  1 
ATOM   1612 C CD1 . TYR A  1 196 ? -13.18459 -19.62126 17.46304  1.000 15.56104 ? 195  TYR A CD1 1 
ATOM   1613 C CD2 . TYR A  1 196 ? -11.39172 -21.17449 17.65014  1.000 22.34676 ? 195  TYR A CD2 1 
ATOM   1614 C CE1 . TYR A  1 196 ? -12.72934 -18.94095 18.60281  1.000 15.43913 ? 195  TYR A CE1 1 
ATOM   1615 C CE2 . TYR A  1 196 ? -10.92446 -20.49707 18.78542  1.000 18.61795 ? 195  TYR A CE2 1 
ATOM   1616 C CZ  . TYR A  1 196 ? -11.59592 -19.38801 19.24184  1.000 19.13084 ? 195  TYR A CZ  1 
ATOM   1617 O OH  . TYR A  1 196 ? -11.13215 -18.72191 20.34657  1.000 20.80426 ? 195  TYR A OH  1 
ATOM   1618 N N   . TYR A  1 197 ? -12.63923 -18.52721 13.81558  1.000 17.12004 ? 196  TYR A N   1 
ATOM   1619 C CA  . TYR A  1 197 ? -13.19610 -17.18163 13.72671  1.000 17.36935 ? 196  TYR A CA  1 
ATOM   1620 C C   . TYR A  1 197 ? -14.43515 -17.11422 12.83809  1.000 19.59024 ? 196  TYR A C   1 
ATOM   1621 O O   . TYR A  1 197 ? -15.40077 -16.42110 13.16678  1.000 17.55882 ? 196  TYR A O   1 
ATOM   1622 C CB  . TYR A  1 197 ? -12.13006 -16.22925 13.19430  1.000 15.97253 ? 196  TYR A CB  1 
ATOM   1623 C CG  . TYR A  1 197 ? -12.54681 -14.78088 13.21363  1.000 17.00278 ? 196  TYR A CG  1 
ATOM   1624 C CD1 . TYR A  1 197 ? -12.71296 -14.09951 14.41973  1.000 16.62968 ? 196  TYR A CD1 1 
ATOM   1625 C CD2 . TYR A  1 197 ? -12.75071 -14.08320 12.03073  1.000 19.67790 ? 196  TYR A CD2 1 
ATOM   1626 C CE1 . TYR A  1 197 ? -13.08173 -12.78216 14.44649  1.000 14.86072 ? 196  TYR A CE1 1 
ATOM   1627 C CE2 . TYR A  1 197 ? -13.13131 -12.75439 12.04386  1.000 19.73561 ? 196  TYR A CE2 1 
ATOM   1628 C CZ  . TYR A  1 197 ? -13.29259 -12.10795 13.26078  1.000 15.99492 ? 196  TYR A CZ  1 
ATOM   1629 O OH  . TYR A  1 197 ? -13.65970 -10.78343 13.29036  1.000 18.21744 ? 196  TYR A OH  1 
ATOM   1630 N N   . SER A  1 198 ? -14.42433 -17.80661 11.69700  1.000 17.60293 ? 197  SER A N   1 
ATOM   1631 C CA  . SER A  1 198 ? -15.54827 -17.65285 10.77416  1.000 18.72853 ? 197  SER A CA  1 
ATOM   1632 C C   . SER A  1 198 ? -16.86372 -18.12666 11.37591  1.000 19.42573 ? 197  SER A C   1 
ATOM   1633 O O   . SER A  1 198 ? -17.93177 -17.67597 10.93614  1.000 21.95243 ? 197  SER A O   1 
ATOM   1634 C CB  . SER A  1 198 ? -15.27342 -18.39436 9.46204   1.000 18.72884 ? 197  SER A CB  1 
ATOM   1635 O OG  . SER A  1 198 ? -15.30623 -19.80474 9.64221   1.000 17.95483 ? 197  SER A OG  1 
ATOM   1636 N N   . LYS A  1 199 ? -16.81802 -19.00328 12.38081  1.000 16.12065 ? 198  LYS A N   1 
ATOM   1637 C CA  . LYS A  1 199 ? -18.02154 -19.53002 13.01457  1.000 15.22057 ? 198  LYS A CA  1 
ATOM   1638 C C   . LYS A  1 199 ? -18.17231 -19.01742 14.43893  1.000 15.86385 ? 198  LYS A C   1 
ATOM   1639 O O   . LYS A  1 199 ? -18.82999 -19.64988 15.26497  1.000 17.15154 ? 198  LYS A O   1 
ATOM   1640 C CB  . LYS A  1 199 ? -18.00639 -21.05246 12.98001  1.000 14.85368 ? 198  LYS A CB  1 
ATOM   1641 C CG  . LYS A  1 199 ? -17.98157 -21.54129 11.52072  1.000 16.77397 ? 198  LYS A CG  1 
ATOM   1642 C CD  . LYS A  1 199 ? -17.69740 -23.01653 11.40244  1.000 16.82902 ? 198  LYS A CD  1 
ATOM   1643 C CE  . LYS A  1 199 ? -17.65183 -23.40147 9.90417   1.000 17.75833 ? 198  LYS A CE  1 
ATOM   1644 N NZ  . LYS A  1 199 ? -17.15281 -24.79062 9.75975   1.000 20.70253 ? 198  LYS A NZ  1 
ATOM   1645 N N   A LEU A  1 200 ? -17.57230 -17.86317 14.73290  0.603 16.66973 ? 199  LEU A N   1 
ATOM   1646 N N   B LEU A  1 200 ? -17.61798 -17.83709 14.71055  0.397 16.70484 ? 199  LEU A N   1 
ATOM   1647 C CA  A LEU A  1 200 ? -17.57624 -17.33826 16.09365  0.603 15.94404 ? 199  LEU A CA  1 
ATOM   1648 C CA  B LEU A  1 200 ? -17.56060 -17.31731 16.07164  0.397 16.00226 ? 199  LEU A CA  1 
ATOM   1649 C C   A LEU A  1 200 ? -18.98614 -17.22876 16.65720  0.603 16.66971 ? 199  LEU A C   1 
ATOM   1650 C C   B LEU A  1 200 ? -18.94676 -17.09971 16.67210  0.397 16.73850 ? 199  LEU A C   1 
ATOM   1651 O O   A LEU A  1 200 ? -19.22403 -17.57127 17.82016  0.603 16.86056 ? 199  LEU A O   1 
ATOM   1652 O O   B LEU A  1 200 ? -19.12365 -17.23699 17.88697  0.397 17.22933 ? 199  LEU A O   1 
ATOM   1653 C CB  A LEU A  1 200 ? -16.89006 -15.97361 16.11884  0.603 17.33269 ? 199  LEU A CB  1 
ATOM   1654 C CB  B LEU A  1 200 ? -16.76115 -16.01750 16.06435  0.397 17.28951 ? 199  LEU A CB  1 
ATOM   1655 C CG  A LEU A  1 200 ? -16.57483 -15.37488 17.48927  0.603 16.79492 ? 199  LEU A CG  1 
ATOM   1656 C CG  B LEU A  1 200 ? -16.12068 -15.52906 17.35493  0.397 17.48225 ? 199  LEU A CG  1 
ATOM   1657 C CD1 A LEU A  1 200 ? -15.72362 -16.33313 18.35165  0.603 16.55389 ? 199  LEU A CD1 1 
ATOM   1658 C CD1 B LEU A  1 200 ? -15.34116 -16.64783 18.03666  0.397 16.87719 ? 199  LEU A CD1 1 
ATOM   1659 C CD2 A LEU A  1 200 ? -15.90341 -14.00939 17.31752  0.603 16.74306 ? 199  LEU A CD2 1 
ATOM   1660 C CD2 B LEU A  1 200 ? -15.21390 -14.35429 17.03094  0.397 15.29123 ? 199  LEU A CD2 1 
ATOM   1661 N N   . ALA A  1 201 ? -19.94234 -16.75312 15.85327  1.000 20.20745 ? 200  ALA A N   1 
ATOM   1662 C CA  . ALA A  1 201 ? -21.28260 -16.55035 16.39952  1.000 18.08195 ? 200  ALA A CA  1 
ATOM   1663 C C   . ALA A  1 201 ? -21.88621 -17.86892 16.87209  1.000 17.97022 ? 200  ALA A C   1 
ATOM   1664 O O   . ALA A  1 201 ? -22.56409 -17.90897 17.90448  1.000 17.61346 ? 200  ALA A O   1 
ATOM   1665 C CB  . ALA A  1 201 ? -22.18778 -15.86812 15.37196  1.000 18.93087 ? 200  ALA A CB  1 
ATOM   1666 N N   . GLN A  1 202 ? -21.62739 -18.96242 16.14722  1.000 16.48533 ? 201  GLN A N   1 
ATOM   1667 C CA  . GLN A  1 202 ? -22.13615 -20.26652 16.56240  1.000 15.18683 ? 201  GLN A CA  1 
ATOM   1668 C C   . GLN A  1 202 ? -21.45364 -20.75869 17.82660  1.000 17.21152 ? 201  GLN A C   1 
ATOM   1669 O O   . GLN A  1 202 ? -22.07724 -21.45328 18.63309  1.000 17.23193 ? 201  GLN A O   1 
ATOM   1670 C CB  . GLN A  1 202 ? -21.93348 -21.29941 15.46085  1.000 16.18181 ? 201  GLN A CB  1 
ATOM   1671 C CG  . GLN A  1 202 ? -22.76040 -21.06120 14.20460  1.000 17.59362 ? 201  GLN A CG  1 
ATOM   1672 C CD  . GLN A  1 202 ? -22.37484 -22.05928 13.14518  1.000 19.42754 ? 201  GLN A CD  1 
ATOM   1673 O OE1 . GLN A  1 202 ? -22.61441 -23.25926 13.30172  1.000 20.39290 ? 201  GLN A OE1 1 
ATOM   1674 N NE2 . GLN A  1 202 ? -21.74725 -21.57942 12.06634  1.000 24.45122 ? 201  GLN A NE2 1 
ATOM   1675 N N   . ILE A  1 203 ? -20.16868 -20.44350 17.98734  1.000 16.63494 ? 202  ILE A N   1 
ATOM   1676 C CA  . ILE A  1 203 ? -19.44472 -20.87349 19.17958  1.000 15.89739 ? 202  ILE A CA  1 
ATOM   1677 C C   . ILE A  1 203 ? -19.95910 -20.14026 20.40522  1.000 15.57188 ? 202  ILE A C   1 
ATOM   1678 O O   . ILE A  1 203 ? -20.13478 -20.73978 21.47215  1.000 16.15319 ? 202  ILE A O   1 
ATOM   1679 C CB  . ILE A  1 203 ? -17.93853 -20.65568 18.98455  1.000 16.07292 ? 202  ILE A CB  1 
ATOM   1680 C CG1 . ILE A  1 203 ? -17.40671 -21.70509 18.01867  1.000 21.13436 ? 202  ILE A CG1 1 
ATOM   1681 C CG2 . ILE A  1 203 ? -17.17269 -20.73091 20.32068  1.000 15.36746 ? 202  ILE A CG2 1 
ATOM   1682 C CD1 . ILE A  1 203 ? -16.09074 -21.35568 17.49515  1.000 20.43584 ? 202  ILE A CD1 1 
ATOM   1683 N N   . VAL A  1 204 ? -20.24105 -18.84556 20.26160  1.000 15.72856 ? 203  VAL A N   1 
ATOM   1684 C CA  . VAL A  1 204 ? -20.61761 -18.02633 21.40930  1.000 17.90207 ? 203  VAL A CA  1 
ATOM   1685 C C   . VAL A  1 204 ? -22.09220 -18.20612 21.77970  1.000 16.74093 ? 203  VAL A C   1 
ATOM   1686 O O   . VAL A  1 204 ? -22.46179 -18.03063 22.94611  1.000 16.20026 ? 203  VAL A O   1 
ATOM   1687 C CB  . VAL A  1 204 ? -20.26785 -16.55845 21.10163  1.000 15.89026 ? 203  VAL A CB  1 
ATOM   1688 C CG1 . VAL A  1 204 ? -20.79219 -15.61394 22.17459  1.000 18.69390 ? 203  VAL A CG1 1 
ATOM   1689 C CG2 . VAL A  1 204 ? -18.74711 -16.39643 20.99355  1.000 18.26664 ? 203  VAL A CG2 1 
ATOM   1690 N N   . ALA A  1 205 ? -22.95641 -18.57178 20.82527  1.000 17.15500 ? 204  ALA A N   1 
ATOM   1691 C CA  . ALA A  1 205 ? -24.39119 -18.64547 21.10966  1.000 18.17351 ? 204  ALA A CA  1 
ATOM   1692 C C   . ALA A  1 205 ? -24.75134 -19.51950 22.30900  1.000 17.16917 ? 204  ALA A C   1 
ATOM   1693 O O   . ALA A  1 205 ? -25.57300 -19.07950 23.13100  1.000 18.37400 ? 204  ALA A O   1 
ATOM   1694 C CB  . ALA A  1 205 ? -25.15090 -19.12156 19.86252  1.000 18.07895 ? 204  ALA A CB  1 
ATOM   1695 N N   . PRO A  1 206 ? -24.20796 -20.73022 22.48480  1.000 17.43406 ? 205  PRO A N   1 
ATOM   1696 C CA  . PRO A  1 206 ? -24.57081 -21.52514 23.66894  1.000 15.71360 ? 205  PRO A CA  1 
ATOM   1697 C C   . PRO A  1 206 ? -23.85383 -21.12632 24.94738  1.000 13.72380 ? 205  PRO A C   1 
ATOM   1698 O O   . PRO A  1 206 ? -24.12092 -21.74521 25.98745  1.000 17.43302 ? 205  PRO A O   1 
ATOM   1699 C CB  . PRO A  1 206 ? -24.17878 -22.95852 23.28690  1.000 17.27829 ? 205  PRO A CB  1 
ATOM   1700 C CG  . PRO A  1 206 ? -23.23215 -22.83318 22.14369  1.000 24.40160 ? 205  PRO A CG  1 
ATOM   1701 C CD  . PRO A  1 206 ? -23.29285 -21.45469 21.58294  1.000 18.77425 ? 205  PRO A CD  1 
ATOM   1702 N N   . LEU A  1 207 ? -22.95962 -20.14001 24.90623  1.000 15.41893 ? 206  LEU A N   1 
ATOM   1703 C CA  . LEU A  1 207 ? -22.15153 -19.78189 26.06900  1.000 16.19993 ? 206  LEU A CA  1 
ATOM   1704 C C   . LEU A  1 207 ? -22.76977 -18.65498 26.88048  1.000 15.83039 ? 206  LEU A C   1 
ATOM   1705 O O   . LEU A  1 207 ? -23.40172 -17.74675 26.34115  1.000 15.86233 ? 206  LEU A O   1 
ATOM   1706 C CB  . LEU A  1 207 ? -20.75421 -19.32643 25.64793  1.000 14.29614 ? 206  LEU A CB  1 
ATOM   1707 C CG  . LEU A  1 207 ? -20.02423 -20.24911 24.67624  1.000 15.22774 ? 206  LEU A CG  1 
ATOM   1708 C CD1 . LEU A  1 207 ? -18.64448 -19.66921 24.37604  1.000 17.54116 ? 206  LEU A CD1 1 
ATOM   1709 C CD2 . LEU A  1 207 ? -19.93439 -21.65378 25.26083  1.000 16.74641 ? 206  LEU A CD2 1 
ATOM   1710 N N   . ASP A  1 208 ? -22.51840 -18.69128 28.19051  1.000 14.53634 ? 207  ASP A N   1 
ATOM   1711 C CA  . ASP A  1 208 ? -22.71613 -17.48961 28.98901  1.000 15.20314 ? 207  ASP A CA  1 
ATOM   1712 C C   . ASP A  1 208 ? -21.59802 -16.48300 28.76410  1.000 17.44142 ? 207  ASP A C   1 
ATOM   1713 O O   . ASP A  1 208 ? -21.84922 -15.27278 28.70165  1.000 17.03793 ? 207  ASP A O   1 
ATOM   1714 C CB  . ASP A  1 208 ? -22.80418 -17.87477 30.46318  1.000 15.73378 ? 207  ASP A CB  1 
ATOM   1715 C CG  . ASP A  1 208 ? -23.98690 -18.75148 30.73877  1.000 16.68178 ? 207  ASP A CG  1 
ATOM   1716 O OD1 . ASP A  1 208 ? -25.09355 -18.19493 30.85980  1.000 18.98101 ? 207  ASP A OD1 1 
ATOM   1717 O OD2 . ASP A  1 208 ? -23.81831 -19.98533 30.79304  1.000 17.64957 ? 207  ASP A OD2 1 
ATOM   1718 N N   . TYR A  1 209 ? -20.36368 -16.96472 28.61146  1.000 15.50960 ? 208  TYR A N   1 
ATOM   1719 C CA  . TYR A  1 209 ? -19.22362 -16.08800 28.39195  1.000 14.63152 ? 208  TYR A CA  1 
ATOM   1720 C C   . TYR A  1 209 ? -18.20147 -16.80731 27.54044  1.000 13.19400 ? 208  TYR A C   1 
ATOM   1721 O O   . TYR A  1 209 ? -18.03476 -18.02566 27.65020  1.000 17.28091 ? 208  TYR A O   1 
ATOM   1722 C CB  . TYR A  1 209 ? -18.52081 -15.67264 29.69369  1.000 15.14715 ? 208  TYR A CB  1 
ATOM   1723 C CG  . TYR A  1 209 ? -19.40103 -14.94874 30.68270  1.000 15.43848 ? 208  TYR A CG  1 
ATOM   1724 C CD1 . TYR A  1 209 ? -19.75895 -13.62426 30.47397  1.000 17.14743 ? 208  TYR A CD1 1 
ATOM   1725 C CD2 . TYR A  1 209 ? -19.85930 -15.59388 31.82586  1.000 18.33787 ? 208  TYR A CD2 1 
ATOM   1726 C CE1 . TYR A  1 209 ? -20.57468 -12.95453 31.39513  1.000 19.33067 ? 208  TYR A CE1 1 
ATOM   1727 C CE2 . TYR A  1 209 ? -20.66240 -14.94017 32.75038  1.000 17.53814 ? 208  TYR A CE2 1 
ATOM   1728 C CZ  . TYR A  1 209 ? -21.01148 -13.62562 32.52285  1.000 19.71992 ? 208  TYR A CZ  1 
ATOM   1729 O OH  . TYR A  1 209 ? -21.81012 -12.98815 33.43981  1.000 19.51325 ? 208  TYR A OH  1 
ATOM   1730 N N   . ILE A  1 210 ? -17.50407 -16.03664 26.71149  1.000 16.23184 ? 209  ILE A N   1 
ATOM   1731 C CA  . ILE A  1 210 ? -16.25790 -16.48106 26.10191  1.000 14.98341 ? 209  ILE A CA  1 
ATOM   1732 C C   . ILE A  1 210 ? -15.13435 -15.68463 26.75833  1.000 15.24434 ? 209  ILE A C   1 
ATOM   1733 O O   . ILE A  1 210 ? -15.08657 -14.44864 26.66086  1.000 15.73360 ? 209  ILE A O   1 
ATOM   1734 C CB  . ILE A  1 210 ? -16.27792 -16.33351 24.56927  1.000 14.15522 ? 209  ILE A CB  1 
ATOM   1735 C CG1 . ILE A  1 210 ? -14.93362 -16.79685 23.97934  1.000 13.87227 ? 209  ILE A CG1 1 
ATOM   1736 C CG2 . ILE A  1 210 ? -16.63877 -14.90470 24.13508  1.000 14.70842 ? 209  ILE A CG2 1 
ATOM   1737 C CD1 . ILE A  1 210 ? -14.95464 -17.05579 22.45407  1.000 13.47326 ? 209  ILE A CD1 1 
ATOM   1738 N N   . ASN A  1 211 ? -14.25351 -16.39014 27.46839  1.000 14.88173 ? 210  ASN A N   1 
ATOM   1739 C CA  . ASN A  1 211 ? -13.21603 -15.74540 28.27311  1.000 13.68635 ? 210  ASN A CA  1 
ATOM   1740 C C   . ASN A  1 211 ? -11.95588 -15.66382 27.42029  1.000 13.66243 ? 210  ASN A C   1 
ATOM   1741 O O   . ASN A  1 211 ? -11.26736 -16.66515 27.21627  1.000 14.79365 ? 210  ASN A O   1 
ATOM   1742 C CB  . ASN A  1 211 ? -12.97281 -16.52708 29.56045  1.000 12.55037 ? 210  ASN A CB  1 
ATOM   1743 C CG  . ASN A  1 211 ? -14.20651 -16.60692 30.44222  1.000 16.14256 ? 210  ASN A CG  1 
ATOM   1744 O OD1 . ASN A  1 211 ? -15.09447 -15.75109 30.36836  1.000 16.54523 ? 210  ASN A OD1 1 
ATOM   1745 N ND2 . ASN A  1 211 ? -14.25801 -17.63017 31.29579  1.000 15.86371 ? 210  ASN A ND2 1 
ATOM   1746 N N   . LEU A  1 212 ? -11.65762 -14.46882 26.91630  1.000 14.18195 ? 211  LEU A N   1 
ATOM   1747 C CA  . LEU A  1 212 ? -10.54480 -14.30527 25.98504  1.000 14.40859 ? 211  LEU A CA  1 
ATOM   1748 C C   . LEU A  1 212 ? -9.21392  -14.43724 26.71322  1.000 17.51045 ? 211  LEU A C   1 
ATOM   1749 O O   . LEU A  1 212 ? -8.98450  -13.75855 27.71451  1.000 15.95301 ? 211  LEU A O   1 
ATOM   1750 C CB  . LEU A  1 212 ? -10.61813 -12.94002 25.32195  1.000 15.35959 ? 211  LEU A CB  1 
ATOM   1751 C CG  . LEU A  1 212 ? -11.88279 -12.56264 24.53925  1.000 20.63820 ? 211  LEU A CG  1 
ATOM   1752 C CD1 . LEU A  1 212 ? -11.60025 -11.36132 23.64456  1.000 15.39767 ? 211  LEU A CD1 1 
ATOM   1753 C CD2 . LEU A  1 212 ? -12.35796 -13.72121 23.70747  1.000 21.23472 ? 211  LEU A CD2 1 
ATOM   1754 N N   . MET A  1 213 ? -8.31751  -15.27814 26.19310  1.000 14.22274 ? 212  MET A N   1 
ATOM   1755 C CA  . MET A  1 213 ? -6.97872  -15.39658 26.78147  1.000 15.86942 ? 212  MET A CA  1 
ATOM   1756 C C   . MET A  1 213 ? -6.09735  -14.28127 26.20768  1.000 14.63005 ? 212  MET A C   1 
ATOM   1757 O O   . MET A  1 213 ? -5.13001  -14.49969 25.47281  1.000 14.15800 ? 212  MET A O   1 
ATOM   1758 C CB  . MET A  1 213 ? -6.40244  -16.78581 26.54452  1.000 14.25301 ? 212  MET A CB  1 
ATOM   1759 C CG  . MET A  1 213 ? -7.09872  -17.82724 27.41180  1.000 14.91159 ? 212  MET A CG  1 
ATOM   1760 S SD  . MET A  1 213 ? -6.51375  -19.51095 27.13975  1.000 18.61801 ? 212  MET A SD  1 
ATOM   1761 C CE  . MET A  1 213 ? -7.29018  -19.89509 25.58080  1.000 15.28627 ? 212  MET A CE  1 
ATOM   1762 N N   . THR A  1 214 ? -6.46047  -13.04657 26.57211  1.000 14.43178 ? 213  THR A N   1 
ATOM   1763 C CA  . THR A  1 214 ? -5.75479  -11.84444 26.13619  1.000 12.61822 ? 213  THR A CA  1 
ATOM   1764 C C   . THR A  1 214 ? -4.51354  -11.61096 27.00651  1.000 17.02769 ? 213  THR A C   1 
ATOM   1765 O O   . THR A  1 214 ? -4.36183  -10.61242 27.71082  1.000 16.46346 ? 213  THR A O   1 
ATOM   1766 C CB  . THR A  1 214 ? -6.69717  -10.64688 26.13908  1.000 14.06170 ? 213  THR A CB  1 
ATOM   1767 O OG1 . THR A  1 214 ? -7.64635  -10.78380 27.20444  1.000 15.90343 ? 213  THR A OG1 1 
ATOM   1768 C CG2 . THR A  1 214 ? -7.46625  -10.59357 24.80985  1.000 14.08308 ? 213  THR A CG2 1 
ATOM   1769 N N   . TYR A  1 215 ? -3.62522  -12.59488 26.93724  1.000 16.37883 ? 214  TYR A N   1 
ATOM   1770 C CA  . TYR A  1 215 ? -2.32184  -12.60286 27.58970  1.000 13.24080 ? 214  TYR A CA  1 
ATOM   1771 C C   . TYR A  1 215 ? -1.48930  -13.62110 26.82122  1.000 17.61347 ? 214  TYR A C   1 
ATOM   1772 O O   . TYR A  1 215 ? -1.96426  -14.20992 25.84506  1.000 16.93371 ? 214  TYR A O   1 
ATOM   1773 C CB  . TYR A  1 215 ? -2.43082  -12.91661 29.09255  1.000 14.82737 ? 214  TYR A CB  1 
ATOM   1774 C CG  . TYR A  1 215 ? -3.34426  -14.06905 29.47874  1.000 15.47142 ? 214  TYR A CG  1 
ATOM   1775 C CD1 . TYR A  1 215 ? -3.01921  -15.38743 29.17225  1.000 17.36311 ? 214  TYR A CD1 1 
ATOM   1776 C CD2 . TYR A  1 215 ? -4.52745  -13.83249 30.17185  1.000 15.65074 ? 214  TYR A CD2 1 
ATOM   1777 C CE1 . TYR A  1 215 ? -3.85915  -16.44591 29.54715  1.000 19.04770 ? 214  TYR A CE1 1 
ATOM   1778 C CE2 . TYR A  1 215 ? -5.36219  -14.87706 30.56087  1.000 15.40993 ? 214  TYR A CE2 1 
ATOM   1779 C CZ  . TYR A  1 215 ? -5.02992  -16.17639 30.24264  1.000 18.04314 ? 214  TYR A CZ  1 
ATOM   1780 O OH  . TYR A  1 215 ? -5.86124  -17.20821 30.63559  1.000 17.97001 ? 214  TYR A OH  1 
ATOM   1781 N N   . ASP A  1 216 ? -0.22783  -13.79261 27.21884  1.000 15.24774 ? 215  ASP A N   1 
ATOM   1782 C CA  . ASP A  1 216 ? 0.71269   -14.58111 26.40950  1.000 14.82297 ? 215  ASP A CA  1 
ATOM   1783 C C   . ASP A  1 216 ? 0.78902   -14.07793 24.96694  1.000 16.17412 ? 215  ASP A C   1 
ATOM   1784 O O   . ASP A  1 216 ? 1.04492   -14.85588 24.03876  1.000 17.23127 ? 215  ASP A O   1 
ATOM   1785 C CB  . ASP A  1 216 ? 0.33913   -16.06309 26.39920  1.000 18.07758 ? 215  ASP A CB  1 
ATOM   1786 C CG  . ASP A  1 216 ? 0.40525   -16.68644 27.75308  1.000 22.72794 ? 215  ASP A CG  1 
ATOM   1787 O OD1 . ASP A  1 216 ? 1.11986   -16.14979 28.62744  1.000 18.23417 ? 215  ASP A OD1 1 
ATOM   1788 O OD2 . ASP A  1 216 ? -0.26179  -17.72287 27.93479  1.000 20.64625 ? 215  ASP A OD2 1 
ATOM   1789 N N   . LEU A  1 217 ? 0.55646   -12.77984 24.75021  1.000 14.04242 ? 216  LEU A N   1 
ATOM   1790 C CA  . LEU A  1 217 ? 0.72029   -12.18975 23.41901  1.000 15.35190 ? 216  LEU A CA  1 
ATOM   1791 C C   . LEU A  1 217 ? 2.17648   -11.86444 23.10962  1.000 15.56139 ? 216  LEU A C   1 
ATOM   1792 O O   . LEU A  1 217 ? 2.48429   -11.36956 22.01294  1.000 17.12757 ? 216  LEU A O   1 
ATOM   1793 C CB  . LEU A  1 217 ? -0.15439  -10.94279 23.28180  1.000 15.55591 ? 216  LEU A CB  1 
ATOM   1794 C CG  . LEU A  1 217 ? -1.63403  -11.21617 23.57864  1.000 16.10793 ? 216  LEU A CG  1 
ATOM   1795 C CD1 . LEU A  1 217 ? -2.46820  -9.94312  23.43528  1.000 16.30894 ? 216  LEU A CD1 1 
ATOM   1796 C CD2 . LEU A  1 217 ? -2.17635  -12.35382 22.67309  1.000 16.16977 ? 216  LEU A CD2 1 
ATOM   1797 N N   . ALA A  1 218 ? 3.06363   -12.14513 24.05691  1.000 15.46760 ? 217  ALA A N   1 
ATOM   1798 C CA  . ALA A  1 218 ? 4.50399   -12.17167 23.86350  1.000 17.49446 ? 217  ALA A CA  1 
ATOM   1799 C C   . ALA A  1 218 ? 5.01768   -13.34105 24.68589  1.000 16.44833 ? 217  ALA A C   1 
ATOM   1800 O O   . ALA A  1 218 ? 4.33004   -13.83257 25.57927  1.000 17.47035 ? 217  ALA A O   1 
ATOM   1801 C CB  . ALA A  1 218 ? 5.17993   -10.86609 24.31132  1.000 18.60795 ? 217  ALA A CB  1 
ATOM   1802 N N   . GLY A  1 219 ? 6.22928   -13.78844 24.38709  1.000 18.01389 ? 218  GLY A N   1 
ATOM   1803 C CA  . GLY A  1 219 ? 6.78696   -14.92415 25.08359  1.000 18.04940 ? 218  GLY A CA  1 
ATOM   1804 C C   . GLY A  1 219 ? 8.09735   -15.32612 24.43944  1.000 18.10226 ? 218  GLY A C   1 
ATOM   1805 O O   . GLY A  1 219 ? 8.52365   -14.72805 23.45278  1.000 17.91059 ? 218  GLY A O   1 
ATOM   1806 N N   . PRO A  1 220 ? 8.78209   -16.31971 25.00757  1.000 18.51520 ? 219  PRO A N   1 
ATOM   1807 C CA  . PRO A  1 220 ? 10.12261  -16.65482 24.50842  1.000 17.74508 ? 219  PRO A CA  1 
ATOM   1808 C C   . PRO A  1 220 ? 10.11263  -17.24197 23.11116  1.000 22.19336 ? 219  PRO A C   1 
ATOM   1809 O O   . PRO A  1 220 ? 11.17339  -17.27469 22.47043  1.000 23.91728 ? 219  PRO A O   1 
ATOM   1810 C CB  . PRO A  1 220 ? 10.64276  -17.66086 25.54690  1.000 22.11212 ? 219  PRO A CB  1 
ATOM   1811 C CG  . PRO A  1 220 ? 9.42323   -18.22543 26.16852  1.000 21.96627 ? 219  PRO A CG  1 
ATOM   1812 C CD  . PRO A  1 220 ? 8.40740   -17.12363 26.18123  1.000 18.18259 ? 219  PRO A CD  1 
ATOM   1813 N N   . TRP A  1 221 ? 8.94581   -17.67339 22.61478  1.000 19.18623 ? 220  TRP A N   1 
ATOM   1814 C CA  . TRP A  1 221 ? 8.79503   -18.16353 21.24690  1.000 20.65492 ? 220  TRP A CA  1 
ATOM   1815 C C   . TRP A  1 221 ? 8.82429   -17.05281 20.20271  1.000 28.89991 ? 220  TRP A C   1 
ATOM   1816 O O   . TRP A  1 221 ? 8.90189   -17.35430 19.00548  1.000 24.56275 ? 220  TRP A O   1 
ATOM   1817 C CB  . TRP A  1 221 ? 7.48234   -18.94689 21.12298  1.000 23.40434 ? 220  TRP A CB  1 
ATOM   1818 C CG  . TRP A  1 221 ? 6.29642   -18.15506 21.59705  1.000 21.28120 ? 220  TRP A CG  1 
ATOM   1819 C CD1 . TRP A  1 221 ? 5.58242   -17.23767 20.87765  1.000 23.10281 ? 220  TRP A CD1 1 
ATOM   1820 C CD2 . TRP A  1 221 ? 5.70634   -18.19166 22.90286  1.000 22.43596 ? 220  TRP A CD2 1 
ATOM   1821 N NE1 . TRP A  1 221 ? 4.57955   -16.70329 21.65985  1.000 22.48926 ? 220  TRP A NE1 1 
ATOM   1822 C CE2 . TRP A  1 221 ? 4.63259   -17.27508 22.90282  1.000 19.65788 ? 220  TRP A CE2 1 
ATOM   1823 C CE3 . TRP A  1 221 ? 5.97578   -18.91674 24.07103  1.000 20.04241 ? 220  TRP A CE3 1 
ATOM   1824 C CZ2 . TRP A  1 221 ? 3.83034   -17.05459 24.03431  1.000 19.70641 ? 220  TRP A CZ2 1 
ATOM   1825 C CZ3 . TRP A  1 221 ? 5.17003   -18.70310 25.19458  1.000 24.48910 ? 220  TRP A CZ3 1 
ATOM   1826 C CH2 . TRP A  1 221 ? 4.11365   -17.77725 25.16406  1.000 21.26822 ? 220  TRP A CH2 1 
ATOM   1827 N N   . GLU A  1 222 ? 8.73243   -15.78842 20.60494  1.000 20.12123 ? 221  GLU A N   1 
ATOM   1828 C CA  . GLU A  1 222 ? 8.87911   -14.67177 19.68618  1.000 22.32419 ? 221  GLU A CA  1 
ATOM   1829 C C   . GLU A  1 222 ? 10.30740  -14.15059 19.75676  1.000 28.05676 ? 221  GLU A C   1 
ATOM   1830 O O   . GLU A  1 222 ? 10.93732  -14.16556 20.81656  1.000 28.95185 ? 221  GLU A O   1 
ATOM   1831 C CB  . GLU A  1 222 ? 7.88666   -13.54847 19.99848  1.000 24.87082 ? 221  GLU A CB  1 
ATOM   1832 C CG  . GLU A  1 222 ? 6.42191   -13.87101 19.66269  1.000 25.42714 ? 221  GLU A CG  1 
ATOM   1833 C CD  . GLU A  1 222 ? 6.21039   -14.16603 18.18315  1.000 32.87271 ? 221  GLU A CD  1 
ATOM   1834 O OE1 . GLU A  1 222 ? 6.95480   -13.60038 17.34905  1.000 29.78406 ? 221  GLU A OE1 1 
ATOM   1835 O OE2 . GLU A  1 222 ? 5.28983   -14.94898 17.85686  1.000 30.93168 ? 221  GLU A OE2 1 
ATOM   1836 N N   A LYS A  1 223 ? 10.80396  -13.65276 18.62846  0.572 25.35136 ? 222  LYS A N   1 
ATOM   1837 N N   B LYS A  1 223 ? 10.81077  -13.70933 18.60001  0.428 25.40372 ? 222  LYS A N   1 
ATOM   1838 C CA  A LYS A  1 223 ? 12.19160  -13.21126 18.57466  0.572 28.69144 ? 222  LYS A CA  1 
ATOM   1839 C CA  B LYS A  1 223 ? 12.21454  -13.32864 18.46768  0.428 28.85327 ? 222  LYS A CA  1 
ATOM   1840 C C   A LYS A  1 223 ? 12.41822  -11.90634 19.33373  0.572 25.34428 ? 222  LYS A C   1 
ATOM   1841 C C   B LYS A  1 223 ? 12.54364  -12.11316 19.32259  0.428 25.46865 ? 222  LYS A C   1 
ATOM   1842 O O   A LYS A  1 223 ? 13.54034  -11.65369 19.79052  0.572 25.20050 ? 222  LYS A O   1 
ATOM   1843 O O   B LYS A  1 223 ? 13.64210  -12.01529 19.88703  0.428 24.58847 ? 222  LYS A O   1 
ATOM   1844 C CB  A LYS A  1 223 ? 12.61719  -13.06076 17.11081  0.572 31.72993 ? 222  LYS A CB  1 
ATOM   1845 C CB  B LYS A  1 223 ? 12.52880  -13.06531 16.98829  0.428 31.50159 ? 222  LYS A CB  1 
ATOM   1846 C CG  A LYS A  1 223 ? 14.10238  -12.87029 16.90392  0.572 35.73297 ? 222  LYS A CG  1 
ATOM   1847 C CG  B LYS A  1 223 ? 13.89463  -12.45457 16.68920  0.428 32.92040 ? 222  LYS A CG  1 
ATOM   1848 C CD  A LYS A  1 223 ? 14.78985  -14.19965 16.61554  0.572 33.38044 ? 222  LYS A CD  1 
ATOM   1849 C CD  B LYS A  1 223 ? 13.83165  -11.53444 15.47073  0.428 34.23665 ? 222  LYS A CD  1 
ATOM   1850 C CE  A LYS A  1 223 ? 15.27036  -14.24795 15.17656  0.572 41.09820 ? 222  LYS A CE  1 
ATOM   1851 C CE  B LYS A  1 223 ? 15.19677  -10.93855 15.13806  0.428 37.31435 ? 222  LYS A CE  1 
ATOM   1852 N NZ  A LYS A  1 223 ? 16.32777  -15.28003 14.88743  0.572 31.04307 ? 222  LYS A NZ  1 
ATOM   1853 N NZ  B LYS A  1 223 ? 15.69806  -11.35064 13.79266  0.428 37.50696 ? 222  LYS A NZ  1 
ATOM   1854 N N   A ILE A  1 224 ? 11.37593  -11.09693 19.50951  0.572 24.17945 ? 223  ILE A N   1 
ATOM   1855 N N   B ILE A  1 224 ? 11.60505  -11.18181 19.43957  0.428 24.61320 ? 223  ILE A N   1 
ATOM   1856 C CA  A ILE A  1 224 ? 11.49025  -9.72932  20.00557  0.572 24.53255 ? 223  ILE A CA  1 
ATOM   1857 C CA  B ILE A  1 224 ? 11.83772  -9.95661  20.18701  0.428 24.10609 ? 223  ILE A CA  1 
ATOM   1858 C C   A ILE A  1 224 ? 10.66358  -9.60332  21.28229  0.572 21.84932 ? 223  ILE A C   1 
ATOM   1859 C C   B ILE A  1 224 ? 10.87201  -9.88112  21.36332  0.428 22.05439 ? 223  ILE A C   1 
ATOM   1860 O O   A ILE A  1 224 ? 9.47158   -9.93462  21.28037  0.572 18.82072 ? 223  ILE A O   1 
ATOM   1861 O O   B ILE A  1 224 ? 9.80985   -10.51195 21.38333  0.428 20.77219 ? 223  ILE A O   1 
ATOM   1862 C CB  A ILE A  1 224 ? 11.00700  -8.72860  18.93916  0.572 23.40631 ? 223  ILE A CB  1 
ATOM   1863 C CB  B ILE A  1 224 ? 11.74021  -8.71088  19.27399  0.428 25.91016 ? 223  ILE A CB  1 
ATOM   1864 C CG1 A ILE A  1 224 ? 11.90267  -8.77551  17.69633  0.572 28.88974 ? 223  ILE A CG1 1 
ATOM   1865 C CG1 B ILE A  1 224 ? 10.37061  -8.04382  19.36589  0.428 24.82467 ? 223  ILE A CG1 1 
ATOM   1866 C CG2 A ILE A  1 224 ? 11.03944  -7.33836  19.47653  0.572 24.20005 ? 223  ILE A CG2 1 
ATOM   1867 C CG2 B ILE A  1 224 ? 12.06621  -9.07099  17.81697  0.428 29.85037 ? 223  ILE A CG2 1 
ATOM   1868 C CD1 A ILE A  1 224 ? 13.37458  -8.62275  18.01071  0.572 22.82559 ? 223  ILE A CD1 1 
ATOM   1869 C CD1 B ILE A  1 224 ? 10.32466  -6.69820  18.68696  0.428 21.27401 ? 223  ILE A CD1 1 
ATOM   1870 N N   . THR A  1 225 ? 11.28313  -9.12579  22.37115  1.000 18.39151 ? 224  THR A N   1 
ATOM   1871 C CA  . THR A  1 225 ? 10.50174  -8.93570  23.58418  1.000 18.57947 ? 224  THR A CA  1 
ATOM   1872 C C   . THR A  1 225 ? 9.36473   -7.96190  23.32663  1.000 17.03639 ? 224  THR A C   1 
ATOM   1873 O O   . THR A  1 225 ? 9.45824   -7.07095  22.48246  1.000 18.81697 ? 224  THR A O   1 
ATOM   1874 C CB  . THR A  1 225 ? 11.34657  -8.38898  24.73564  1.000 18.94387 ? 224  THR A CB  1 
ATOM   1875 O OG1 . THR A  1 225 ? 11.74055  -7.04471  24.43698  1.000 17.99168 ? 224  THR A OG1 1 
ATOM   1876 C CG2 . THR A  1 225 ? 12.58193  -9.26877  25.01053  1.000 21.36548 ? 224  THR A CG2 1 
ATOM   1877 N N   . ASN A  1 226 ? 8.29151   -8.12740  24.08756  1.000 19.13188 ? 225  ASN A N   1 
ATOM   1878 C CA  . ASN A  1 226 ? 7.11437   -7.29711  23.92060  1.000 16.83253 ? 225  ASN A CA  1 
ATOM   1879 C C   . ASN A  1 226 ? 6.25874   -7.46034  25.16571  1.000 17.22424 ? 225  ASN A C   1 
ATOM   1880 O O   . ASN A  1 226 ? 6.46582   -8.37128  25.97641  1.000 16.42304 ? 225  ASN A O   1 
ATOM   1881 C CB  . ASN A  1 226 ? 6.33806   -7.69180  22.64612  1.000 16.77625 ? 225  ASN A CB  1 
ATOM   1882 C CG  . ASN A  1 226 ? 5.22786   -6.70897  22.29554  1.000 21.12972 ? 225  ASN A CG  1 
ATOM   1883 O OD1 . ASN A  1 226 ? 5.26252   -5.53665  22.68042  1.000 21.86933 ? 225  ASN A OD1 1 
ATOM   1884 N ND2 . ASN A  1 226 ? 4.21609   -7.19608  21.57371  1.000 25.26838 ? 225  ASN A ND2 1 
ATOM   1885 N N   . HIS A  1 227 ? 5.31277   -6.54251  25.31889  1.000 17.98764 ? 226  HIS A N   1 
ATOM   1886 C CA  . HIS A  1 227 ? 4.29024   -6.67015  26.34752  1.000 18.14012 ? 226  HIS A CA  1 
ATOM   1887 C C   . HIS A  1 227 ? 3.37285   -7.83677  26.00503  1.000 17.46006 ? 226  HIS A C   1 
ATOM   1888 O O   . HIS A  1 227 ? 2.95095   -7.98355  24.84750  1.000 16.88508 ? 226  HIS A O   1 
ATOM   1889 C CB  . HIS A  1 227 ? 3.50985   -5.36121  26.44376  1.000 18.96016 ? 226  HIS A CB  1 
ATOM   1890 C CG  . HIS A  1 227 ? 4.39044   -4.18521  26.71924  1.000 19.97359 ? 226  HIS A CG  1 
ATOM   1891 N ND1 . HIS A  1 227 ? 4.79511   -3.84545  27.99215  1.000 22.22730 ? 226  HIS A ND1 1 
ATOM   1892 C CD2 . HIS A  1 227 ? 5.00929   -3.32005  25.88054  1.000 19.92943 ? 226  HIS A CD2 1 
ATOM   1893 C CE1 . HIS A  1 227 ? 5.60009   -2.79961  27.92900  1.000 25.32690 ? 226  HIS A CE1 1 
ATOM   1894 N NE2 . HIS A  1 227 ? 5.74780   -2.46195  26.65971  1.000 22.84849 ? 226  HIS A NE2 1 
ATOM   1895 N N   . GLN A  1 228 ? 3.09517   -8.69203  26.99711  1.000 15.46770 ? 227  GLN A N   1 
ATOM   1896 C CA  . GLN A  1 228 ? 2.26531   -9.86579  26.75040  1.000 15.53313 ? 227  GLN A CA  1 
ATOM   1897 C C   . GLN A  1 228 ? 0.77811   -9.56255  26.79999  1.000 15.35766 ? 227  GLN A C   1 
ATOM   1898 O O   . GLN A  1 228 ? -0.03118  -10.43552 26.45935  1.000 15.59415 ? 227  GLN A O   1 
ATOM   1899 C CB  . GLN A  1 228 ? 2.57402   -10.98490 27.75488  1.000 14.89677 ? 227  GLN A CB  1 
ATOM   1900 C CG  . GLN A  1 228 ? 2.14607   -10.67784 29.19454  1.000 15.05932 ? 227  GLN A CG  1 
ATOM   1901 C CD  . GLN A  1 228 ? 1.89450   -11.93622 30.00678  1.000 17.41654 ? 227  GLN A CD  1 
ATOM   1902 O OE1 . GLN A  1 228 ? 1.59865   -13.00356 29.45479  1.000 19.13654 ? 227  GLN A OE1 1 
ATOM   1903 N NE2 . GLN A  1 228 ? 2.05289   -11.82694 31.32822  1.000 14.51506 ? 227  GLN A NE2 1 
ATOM   1904 N N   . ALA A  1 229 ? 0.38764   -8.37583  27.24962  1.000 14.80561 ? 228  ALA A N   1 
ATOM   1905 C CA  . ALA A  1 229 ? -1.02820  -8.04684  27.31736  1.000 16.05422 ? 228  ALA A CA  1 
ATOM   1906 C C   . ALA A  1 229 ? -1.20821  -6.53516  27.18511  1.000 16.00397 ? 228  ALA A C   1 
ATOM   1907 O O   . ALA A  1 229 ? -1.90539  -5.89875  27.97469  1.000 17.46205 ? 228  ALA A O   1 
ATOM   1908 C CB  . ALA A  1 229 ? -1.64154  -8.58476  28.61303  1.000 16.04041 ? 228  ALA A CB  1 
ATOM   1909 N N   . ALA A  1 230 ? -0.57255  -5.94350  26.17476  1.000 14.70494 ? 229  ALA A N   1 
ATOM   1910 C CA  . ALA A  1 230 ? -0.76864  -4.52254  25.91132  1.000 14.66499 ? 229  ALA A CA  1 
ATOM   1911 C C   . ALA A  1 230 ? -2.24325  -4.23817  25.66588  1.000 17.88291 ? 229  ALA A C   1 
ATOM   1912 O O   . ALA A  1 230 ? -2.90600  -4.95920  24.91596  1.000 17.99507 ? 229  ALA A O   1 
ATOM   1913 C CB  . ALA A  1 230 ? 0.04827   -4.09470  24.69047  1.000 14.29606 ? 229  ALA A CB  1 
ATOM   1914 N N   . LEU A  1 231 ? -2.77036  -3.19153  26.30138  1.000 17.09689 ? 230  LEU A N   1 
ATOM   1915 C CA  . LEU A  1 231 ? -4.15720  -2.82731  26.01759  1.000 16.24494 ? 230  LEU A CA  1 
ATOM   1916 C C   . LEU A  1 231 ? -4.28014  -2.25299  24.61086  1.000 17.57260 ? 230  LEU A C   1 
ATOM   1917 O O   . LEU A  1 231 ? -5.10974  -2.71173  23.81219  1.000 16.95776 ? 230  LEU A O   1 
ATOM   1918 C CB  . LEU A  1 231 ? -4.68538  -1.83574  27.05824  1.000 16.43499 ? 230  LEU A CB  1 
ATOM   1919 C CG  . LEU A  1 231 ? -6.13049  -1.38105  26.79199  1.000 18.96151 ? 230  LEU A CG  1 
ATOM   1920 C CD1 . LEU A  1 231 ? -7.06512  -2.57324  26.60244  1.000 17.30944 ? 230  LEU A CD1 1 
ATOM   1921 C CD2 . LEU A  1 231 ? -6.64495  -0.47305  27.92183  1.000 17.70753 ? 230  LEU A CD2 1 
ATOM   1922 N N   . PHE A  1 232 ? -3.45857  -1.25389  24.29358  1.000 18.09296 ? 231  PHE A N   1 
ATOM   1923 C CA  . PHE A  1 232 ? -3.39262  -0.63640  22.97541  1.000 18.95586 ? 231  PHE A CA  1 
ATOM   1924 C C   . PHE A  1 232 ? -1.98170  -0.78323  22.42258  1.000 19.67848 ? 231  PHE A C   1 
ATOM   1925 O O   . PHE A  1 232 ? -1.05443  -1.19823  23.12091  1.000 19.12373 ? 231  PHE A O   1 
ATOM   1926 C CB  . PHE A  1 232 ? -3.79500  0.84768   23.03970  1.000 17.53793 ? 231  PHE A CB  1 
ATOM   1927 C CG  . PHE A  1 232 ? -5.18037  1.08327   23.57999  1.000 19.09535 ? 231  PHE A CG  1 
ATOM   1928 C CD1 . PHE A  1 232 ? -6.30192  0.61628   22.90444  1.000 21.17330 ? 231  PHE A CD1 1 
ATOM   1929 C CD2 . PHE A  1 232 ? -5.35951  1.76530   24.78104  1.000 20.48696 ? 231  PHE A CD2 1 
ATOM   1930 C CE1 . PHE A  1 232 ? -7.58088  0.84297   23.40420  1.000 20.89198 ? 231  PHE A CE1 1 
ATOM   1931 C CE2 . PHE A  1 232 ? -6.63376  1.99351   25.28217  1.000 21.48986 ? 231  PHE A CE2 1 
ATOM   1932 C CZ  . PHE A  1 232 ? -7.74320  1.53043   24.59161  1.000 21.62394 ? 231  PHE A CZ  1 
ATOM   1933 N N   . GLY A  1 233 ? -1.81448  -0.44104  21.14942  1.000 17.94211 ? 232  GLY A N   1 
ATOM   1934 C CA  . GLY A  1 233 ? -0.55349  -0.67070  20.47074  1.000 20.07062 ? 232  GLY A CA  1 
ATOM   1935 C C   . GLY A  1 233 ? 0.45997   0.45141   20.63344  1.000 20.79982 ? 232  GLY A C   1 
ATOM   1936 O O   . GLY A  1 233 ? 0.11859   1.61423   20.81319  1.000 18.80916 ? 232  GLY A O   1 
ATOM   1937 N N   . ASP A  1 234 ? 1.72770   0.07609   20.53444  1.000 21.21922 ? 233  ASP A N   1 
ATOM   1938 C CA  . ASP A  1 234 ? 2.85076   1.00534   20.52401  1.000 18.93382 ? 233  ASP A CA  1 
ATOM   1939 C C   . ASP A  1 234 ? 3.48005   0.90460   19.14256  1.000 21.99280 ? 233  ASP A C   1 
ATOM   1940 O O   . ASP A  1 234 ? 3.91250   -0.17873  18.74061  1.000 19.72991 ? 233  ASP A O   1 
ATOM   1941 C CB  . ASP A  1 234 ? 3.84681   0.63128   21.62816  1.000 20.14402 ? 233  ASP A CB  1 
ATOM   1942 C CG  . ASP A  1 234 ? 5.05128   1.56259   21.71072  1.000 24.70688 ? 233  ASP A CG  1 
ATOM   1943 O OD1 . ASP A  1 234 ? 5.20700   2.48437   20.87884  1.000 20.90309 ? 233  ASP A OD1 1 
ATOM   1944 O OD2 . ASP A  1 234 ? 5.86666   1.35120   22.63320  1.000 20.89037 ? 233  ASP A OD2 1 
ATOM   1945 N N   . ALA A  1 235 ? 3.51419   2.02186   18.41278  1.000 22.15109 ? 234  ALA A N   1 
ATOM   1946 C CA  . ALA A  1 235 ? 4.09576   2.00880   17.07030  1.000 25.75367 ? 234  ALA A CA  1 
ATOM   1947 C C   . ALA A  1 235 ? 5.56434   1.59269   17.06679  1.000 23.56290 ? 234  ALA A C   1 
ATOM   1948 O O   . ALA A  1 235 ? 6.06254   1.12085   16.03866  1.000 24.57779 ? 234  ALA A O   1 
ATOM   1949 C CB  . ALA A  1 235 ? 3.94108   3.38434   16.41714  1.000 32.89946 ? 234  ALA A CB  1 
ATOM   1950 N N   . ALA A  1 236 ? 6.26902   1.74616   18.18927  1.000 23.08449 ? 235  ALA A N   1 
ATOM   1951 C CA  . ALA A  1 236 ? 7.64771   1.29045   18.27567  1.000 21.66768 ? 235  ALA A CA  1 
ATOM   1952 C C   . ALA A  1 236 ? 7.76032   -0.21807  18.44313  1.000 20.78186 ? 235  ALA A C   1 
ATOM   1953 O O   . ALA A  1 236 ? 8.85614   -0.76823  18.26421  1.000 23.23689 ? 235  ALA A O   1 
ATOM   1954 C CB  . ALA A  1 236 ? 8.36470   1.99211   19.43840  1.000 23.60302 ? 235  ALA A CB  1 
ATOM   1955 N N   . GLY A  1 237 ? 6.66435   -0.89521  18.77893  1.000 19.91341 ? 236  GLY A N   1 
ATOM   1956 C CA  . GLY A  1 237 ? 6.69764   -2.31313  19.04556  1.000 18.63408 ? 236  GLY A CA  1 
ATOM   1957 C C   . GLY A  1 237 ? 6.47099   -3.12905  17.79381  1.000 20.16254 ? 236  GLY A C   1 
ATOM   1958 O O   . GLY A  1 237 ? 6.18859   -2.58886  16.72150  1.000 20.19108 ? 236  GLY A O   1 
ATOM   1959 N N   . PRO A  1 238 ? 6.60362   -4.44902  17.90512  1.000 19.48313 ? 237  PRO A N   1 
ATOM   1960 C CA  . PRO A  1 238 ? 6.42314   -5.30690  16.73130  1.000 24.27196 ? 237  PRO A CA  1 
ATOM   1961 C C   . PRO A  1 238 ? 4.98375   -5.30002  16.24568  1.000 20.43814 ? 237  PRO A C   1 
ATOM   1962 O O   . PRO A  1 238 ? 4.04762   -4.95967  16.97046  1.000 19.82640 ? 237  PRO A O   1 
ATOM   1963 C CB  . PRO A  1 238 ? 6.82436   -6.69653  17.23643  1.000 21.80431 ? 237  PRO A CB  1 
ATOM   1964 C CG  . PRO A  1 238 ? 6.56188   -6.64229  18.71621  1.000 23.03011 ? 237  PRO A CG  1 
ATOM   1965 C CD  . PRO A  1 238 ? 6.92794   -5.22652  19.11638  1.000 20.21300 ? 237  PRO A CD  1 
ATOM   1966 N N   . THR A  1 239 ? 4.82387   -5.68327  14.98065  1.000 19.29342 ? 238  THR A N   1 
ATOM   1967 C CA  . THR A  1 239 ? 3.51095   -5.89653  14.39779  1.000 18.67585 ? 238  THR A CA  1 
ATOM   1968 C C   . THR A  1 239 ? 3.46073   -7.29519  13.80800  1.000 19.80920 ? 238  THR A C   1 
ATOM   1969 O O   . THR A  1 239 ? 4.49373   -7.93804  13.59339  1.000 20.10608 ? 238  THR A O   1 
ATOM   1970 C CB  . THR A  1 239 ? 3.17905   -4.85305  13.32135  1.000 19.45737 ? 238  THR A CB  1 
ATOM   1971 O OG1 . THR A  1 239 ? 4.17526   -4.88690  12.29049  1.000 21.15512 ? 238  THR A OG1 1 
ATOM   1972 C CG2 . THR A  1 239 ? 3.11330   -3.45802  13.94284  1.000 23.32914 ? 238  THR A CG2 1 
ATOM   1973 N N   . PHE A  1 240 ? 2.24104   -7.75371  13.53626  1.000 16.60856 ? 239  PHE A N   1 
ATOM   1974 C CA  . PHE A  1 240 ? 1.99924   -9.12253  13.11336  1.000 15.24784 ? 239  PHE A CA  1 
ATOM   1975 C C   . PHE A  1 240 ? 1.06073   -9.15221  11.91715  1.000 16.90778 ? 239  PHE A C   1 
ATOM   1976 O O   . PHE A  1 240 ? 0.19309   -8.29002  11.76713  1.000 17.76153 ? 239  PHE A O   1 
ATOM   1977 C CB  . PHE A  1 240 ? 1.38616   -9.94134  14.25757  1.000 17.99474 ? 239  PHE A CB  1 
ATOM   1978 C CG  . PHE A  1 240 ? 2.33955   -10.18901 15.39216  1.000 17.38397 ? 239  PHE A CG  1 
ATOM   1979 C CD1 . PHE A  1 240 ? 2.50577   -9.24681  16.39450  1.000 17.60699 ? 239  PHE A CD1 1 
ATOM   1980 C CD2 . PHE A  1 240 ? 3.08298   -11.35351 15.43342  1.000 25.57464 ? 239  PHE A CD2 1 
ATOM   1981 C CE1 . PHE A  1 240 ? 3.39990   -9.47554  17.42726  1.000 18.15100 ? 239  PHE A CE1 1 
ATOM   1982 C CE2 . PHE A  1 240 ? 3.96996   -11.58785 16.46565  1.000 27.39934 ? 239  PHE A CE2 1 
ATOM   1983 C CZ  . PHE A  1 240 ? 4.11737   -10.64286 17.46401  1.000 20.47564 ? 239  PHE A CZ  1 
ATOM   1984 N N   . TYR A  1 241 ? 1.24559   -10.16857 11.08143  1.000 16.56987 ? 240  TYR A N   1 
ATOM   1985 C CA  . TYR A  1 241 ? 0.28194   -10.47125 10.03172  1.000 16.24279 ? 240  TYR A CA  1 
ATOM   1986 C C   . TYR A  1 241 ? -1.09158  -10.72288 10.63802  1.000 18.29060 ? 240  TYR A C   1 
ATOM   1987 O O   . TYR A  1 241 ? -1.21641  -11.37730 11.67443  1.000 18.80805 ? 240  TYR A O   1 
ATOM   1988 C CB  . TYR A  1 241 ? 0.74647   -11.70411 9.25490   1.000 14.63067 ? 240  TYR A CB  1 
ATOM   1989 C CG  . TYR A  1 241 ? -0.05773  -12.00339 8.01589   1.000 16.32096 ? 240  TYR A CG  1 
ATOM   1990 C CD1 . TYR A  1 241 ? -1.25116  -12.71030 8.09215   1.000 16.43370 ? 240  TYR A CD1 1 
ATOM   1991 C CD2 . TYR A  1 241 ? 0.38533   -11.58774 6.77283   1.000 18.28802 ? 240  TYR A CD2 1 
ATOM   1992 C CE1 . TYR A  1 241 ? -1.98999  -12.99645 6.94852   1.000 17.67707 ? 240  TYR A CE1 1 
ATOM   1993 C CE2 . TYR A  1 241 ? -0.34107  -11.86312 5.63566   1.000 17.82432 ? 240  TYR A CE2 1 
ATOM   1994 C CZ  . TYR A  1 241 ? -1.52316  -12.56065 5.73312   1.000 18.14359 ? 240  TYR A CZ  1 
ATOM   1995 O OH  . TYR A  1 241 ? -2.25244  -12.82909 4.60251   1.000 18.59884 ? 240  TYR A OH  1 
ATOM   1996 N N   . ASN A  1 242 ? -2.13773  -10.22069 9.97452   1.000 15.96170 ? 241  ASN A N   1 
ATOM   1997 C CA  . ASN A  1 242 ? -3.50742  -10.43123 10.44337  1.000 17.82203 ? 241  ASN A CA  1 
ATOM   1998 C C   . ASN A  1 242 ? -4.08421  -11.66442 9.75930   1.000 18.13943 ? 241  ASN A C   1 
ATOM   1999 O O   . ASN A  1 242 ? -4.68179  -11.58513 8.68417   1.000 17.26332 ? 241  ASN A O   1 
ATOM   2000 C CB  . ASN A  1 242 ? -4.35579  -9.18819  10.19510  1.000 16.23912 ? 241  ASN A CB  1 
ATOM   2001 C CG  . ASN A  1 242 ? -5.65024  -9.20007  10.99028  1.000 14.77599 ? 241  ASN A CG  1 
ATOM   2002 O OD1 . ASN A  1 242 ? -6.18775  -10.25884 11.31638  1.000 17.13321 ? 241  ASN A OD1 1 
ATOM   2003 N ND2 . ASN A  1 242 ? -6.15961  -8.01630  11.29906  1.000 16.05700 ? 241  ASN A ND2 1 
ATOM   2004 N N   . ALA A  1 243 ? -3.94996  -12.82040 10.41998  1.000 15.35593 ? 242  ALA A N   1 
ATOM   2005 C CA  . ALA A  1 243 ? -4.37593  -14.08375 9.82112   1.000 16.62551 ? 242  ALA A CA  1 
ATOM   2006 C C   . ALA A  1 243 ? -5.87585  -14.13528 9.56104   1.000 15.57417 ? 242  ALA A C   1 
ATOM   2007 O O   . ALA A  1 243 ? -6.32167  -14.95692 8.75414   1.000 16.96992 ? 242  ALA A O   1 
ATOM   2008 C CB  . ALA A  1 243 ? -3.96818  -15.25411 10.71585  1.000 19.16895 ? 242  ALA A CB  1 
ATOM   2009 N N   . LEU A  1 244 ? -6.66414  -13.28541 10.22562  1.000 15.57125 ? 243  LEU A N   1 
ATOM   2010 C CA  . LEU A  1 244 ? -8.10705  -13.33442 10.03612  1.000 13.85235 ? 243  LEU A CA  1 
ATOM   2011 C C   . LEU A  1 244 ? -8.48963  -13.00340 8.60203   1.000 14.80301 ? 243  LEU A C   1 
ATOM   2012 O O   . LEU A  1 244 ? -9.53950  -13.44400 8.13499   1.000 17.44939 ? 243  LEU A O   1 
ATOM   2013 C CB  . LEU A  1 244 ? -8.81512  -12.37786 10.99340  1.000 16.06192 ? 243  LEU A CB  1 
ATOM   2014 C CG  . LEU A  1 244 ? -8.52983  -12.62119 12.48433  1.000 17.32472 ? 243  LEU A CG  1 
ATOM   2015 C CD1 . LEU A  1 244 ? -9.27803  -11.58297 13.31787  1.000 15.31526 ? 243  LEU A CD1 1 
ATOM   2016 C CD2 . LEU A  1 244 ? -8.91518  -14.04333 12.88673  1.000 17.93390 ? 243  LEU A CD2 1 
ATOM   2017 N N   . ARG A  1 245 ? -7.66298  -12.23566 7.89343   1.000 15.22102 ? 244  ARG A N   1 
ATOM   2018 C CA  . ARG A  1 245 ? -8.03687  -11.89057 6.52280   1.000 16.42420 ? 244  ARG A CA  1 
ATOM   2019 C C   . ARG A  1 245 ? -7.99464  -13.08807 5.58199   1.000 18.31026 ? 244  ARG A C   1 
ATOM   2020 O O   . ARG A  1 245 ? -8.51891  -12.99334 4.46412   1.000 16.72968 ? 244  ARG A O   1 
ATOM   2021 C CB  . ARG A  1 245 ? -7.15432  -10.75362 5.99967   1.000 18.93033 ? 244  ARG A CB  1 
ATOM   2022 C CG  . ARG A  1 245 ? -5.76378  -11.14060 5.51922   1.000 17.01755 ? 244  ARG A CG  1 
ATOM   2023 C CD  . ARG A  1 245 ? -5.00145  -9.88403  5.10082   1.000 16.72667 ? 244  ARG A CD  1 
ATOM   2024 N NE  . ARG A  1 245 ? -3.67999  -10.15733 4.53878   1.000 17.52827 ? 244  ARG A NE  1 
ATOM   2025 C CZ  . ARG A  1 245 ? -2.85732  -9.20595  4.11909   1.000 19.15179 ? 244  ARG A CZ  1 
ATOM   2026 N NH1 . ARG A  1 245 ? -3.18947  -7.92447  4.19756   1.000 18.24863 ? 244  ARG A NH1 1 
ATOM   2027 N NH2 . ARG A  1 245 ? -1.68277  -9.54572  3.59104   1.000 18.35710 ? 244  ARG A NH2 1 
ATOM   2028 N N   . GLU A  1 246 ? -7.42939  -14.21554 6.01688   1.000 17.51231 ? 245  GLU A N   1 
ATOM   2029 C CA  . GLU A  1 246 ? -7.40904  -15.44247 5.23703   1.000 17.11694 ? 245  GLU A CA  1 
ATOM   2030 C C   . GLU A  1 246 ? -8.42895  -16.46117 5.71984   1.000 18.19138 ? 245  GLU A C   1 
ATOM   2031 O O   . GLU A  1 246 ? -8.44541  -17.59142 5.22416   1.000 18.12323 ? 245  GLU A O   1 
ATOM   2032 C CB  . GLU A  1 246 ? -6.00081  -16.04850 5.26639   1.000 16.30142 ? 245  GLU A CB  1 
ATOM   2033 C CG  . GLU A  1 246 ? -4.95400  -15.12373 4.65056   1.000 16.36503 ? 245  GLU A CG  1 
ATOM   2034 C CD  . GLU A  1 246 ? -5.26486  -14.83676 3.18760   1.000 18.63334 ? 245  GLU A CD  1 
ATOM   2035 O OE1 . GLU A  1 246 ? -5.19288  -15.77243 2.36622   1.000 16.59737 ? 245  GLU A OE1 1 
ATOM   2036 O OE2 . GLU A  1 246 ? -5.60536  -13.67761 2.87893   1.000 16.63320 ? 245  GLU A OE2 1 
ATOM   2037 N N   . ALA A  1 247 ? -9.26282  -16.10141 6.68847   1.000 18.07401 ? 246  ALA A N   1 
ATOM   2038 C CA  . ALA A  1 247 ? -10.27509 -17.02188 7.16827   1.000 16.13793 ? 246  ALA A CA  1 
ATOM   2039 C C   . ALA A  1 247 ? -11.36440 -17.19466 6.11947   1.000 20.11427 ? 246  ALA A C   1 
ATOM   2040 O O   . ALA A  1 247 ? -11.55095 -16.35021 5.24011   1.000 20.18706 ? 246  ALA A O   1 
ATOM   2041 C CB  . ALA A  1 247 ? -10.86696 -16.51721 8.48804   1.000 17.76486 ? 246  ALA A CB  1 
ATOM   2042 N N   . ASN A  1 248 ? -12.07982 -18.31850 6.20413   1.000 15.97315 ? 247  ASN A N   1 
ATOM   2043 C CA  . ASN A  1 248 ? -13.07941 -18.66856 5.18511   1.000 16.48795 ? 247  ASN A CA  1 
ATOM   2044 C C   . ASN A  1 248 ? -14.40024 -17.95098 5.48139   1.000 16.96266 ? 247  ASN A C   1 
ATOM   2045 O O   . ASN A  1 248 ? -15.38513 -18.53833 5.93538   1.000 18.62060 ? 247  ASN A O   1 
ATOM   2046 C CB  . ASN A  1 248 ? -13.27650 -20.17477 5.11883   1.000 21.21842 ? 247  ASN A CB  1 
ATOM   2047 C CG  . ASN A  1 248 ? -14.19319 -20.58293 3.98358   1.000 26.18989 ? 247  ASN A CG  1 
ATOM   2048 O OD1 . ASN A  1 248 ? -14.33240 -19.85455 3.00746   1.000 25.50271 ? 247  ASN A OD1 1 
ATOM   2049 N ND2 . ASN A  1 248 ? -14.83373 -21.73716 4.11216   1.000 29.95100 ? 247  ASN A ND2 1 
ATOM   2050 N N   . LEU A  1 249 ? -14.40651 -16.64517 5.20038   1.000 16.44009 ? 248  LEU A N   1 
ATOM   2051 C CA  . LEU A  1 249 ? -15.52775 -15.76612 5.51766   1.000 16.01614 ? 248  LEU A CA  1 
ATOM   2052 C C   . LEU A  1 249 ? -16.44081 -15.50185 4.32990   1.000 19.09822 ? 248  LEU A C   1 
ATOM   2053 O O   . LEU A  1 249 ? -17.60823 -15.13780 4.53096   1.000 19.59482 ? 248  LEU A O   1 
ATOM   2054 C CB  . LEU A  1 249 ? -15.01512 -14.41732 6.02830   1.000 17.92015 ? 248  LEU A CB  1 
ATOM   2055 C CG  . LEU A  1 249 ? -14.26794 -14.48082 7.36222   1.000 18.28511 ? 248  LEU A CG  1 
ATOM   2056 C CD1 . LEU A  1 249 ? -13.42022 -13.23944 7.58085   1.000 18.91078 ? 248  LEU A CD1 1 
ATOM   2057 C CD2 . LEU A  1 249 ? -15.28484 -14.64027 8.46972   1.000 19.54314 ? 248  LEU A CD2 1 
ATOM   2058 N N   . GLY A  1 250 ? -15.93399 -15.66945 3.11777   1.000 19.35538 ? 249  GLY A N   1 
ATOM   2059 C CA  . GLY A  1 250 ? -16.69685 -15.33203 1.92942   1.000 22.50466 ? 249  GLY A CA  1 
ATOM   2060 C C   . GLY A  1 250 ? -16.86021 -13.84960 1.69001   1.000 23.96697 ? 249  GLY A C   1 
ATOM   2061 O O   . GLY A  1 250 ? -17.72833 -13.45566 0.90001   1.000 26.08105 ? 249  GLY A O   1 
ATOM   2062 N N   . TRP A  1 251 ? -16.02723 -13.01690 2.31351   1.000 16.75772 ? 250  TRP A N   1 
ATOM   2063 C CA  . TRP A  1 251 ? -16.11373 -11.56456 2.21205   1.000 15.77671 ? 250  TRP A CA  1 
ATOM   2064 C C   . TRP A  1 251 ? -15.31440 -11.06178 1.00453   1.000 17.33682 ? 250  TRP A C   1 
ATOM   2065 O O   . TRP A  1 251 ? -14.46611 -11.76860 0.44757   1.000 19.92115 ? 250  TRP A O   1 
ATOM   2066 C CB  . TRP A  1 251 ? -15.58124 -10.89717 3.48181   1.000 19.01977 ? 250  TRP A CB  1 
ATOM   2067 C CG  . TRP A  1 251 ? -16.40687 -11.14215 4.71431   1.000 16.22204 ? 250  TRP A CG  1 
ATOM   2068 C CD1 . TRP A  1 251 ? -17.53597 -11.90558 4.81516   1.000 18.40398 ? 250  TRP A CD1 1 
ATOM   2069 C CD2 . TRP A  1 251 ? -16.12227 -10.65792 6.03681   1.000 16.58533 ? 250  TRP A CD2 1 
ATOM   2070 N NE1 . TRP A  1 251 ? -17.98395 -11.90957 6.13267   1.000 18.88480 ? 250  TRP A NE1 1 
ATOM   2071 C CE2 . TRP A  1 251 ? -17.13030 -11.15288 6.89322   1.000 19.46815 ? 250  TRP A CE2 1 
ATOM   2072 C CE3 . TRP A  1 251 ? -15.11961 -9.84385  6.57368   1.000 17.41985 ? 250  TRP A CE3 1 
ATOM   2073 C CZ2 . TRP A  1 251 ? -17.16406 -10.85924 8.25997   1.000 22.23039 ? 250  TRP A CZ2 1 
ATOM   2074 C CZ3 . TRP A  1 251 ? -15.15396 -9.55223  7.94702   1.000 18.38275 ? 250  TRP A CZ3 1 
ATOM   2075 C CH2 . TRP A  1 251 ? -16.16988 -10.05831 8.76196   1.000 18.98963 ? 250  TRP A CH2 1 
ATOM   2076 N N   . SER A  1 252 ? -15.57803 -9.81555  0.61449   1.000 16.43570 ? 251  SER A N   1 
ATOM   2077 C CA  . SER A  1 252 ? -14.91181 -9.21449  -0.53900  1.000 15.99691 ? 251  SER A CA  1 
ATOM   2078 C C   . SER A  1 252 ? -13.58336 -8.58151  -0.11986  1.000 16.95331 ? 251  SER A C   1 
ATOM   2079 O O   . SER A  1 252 ? -13.28447 -8.44309  1.06233   1.000 17.54234 ? 251  SER A O   1 
ATOM   2080 C CB  . SER A  1 252 ? -15.80934 -8.15560  -1.17229  1.000 16.13740 ? 251  SER A CB  1 
ATOM   2081 O OG  . SER A  1 252 ? -15.76445 -6.96699  -0.39201  1.000 16.39996 ? 251  SER A OG  1 
ATOM   2082 N N   . TRP A  1 253 ? -12.78115 -8.16739  -1.10838  1.000 15.85668 ? 252  TRP A N   1 
ATOM   2083 C CA  . TRP A  1 253 ? -11.51205 -7.51333  -0.78603  1.000 13.82266 ? 252  TRP A CA  1 
ATOM   2084 C C   . TRP A  1 253 ? -11.72521 -6.29501  0.10990   1.000 17.34204 ? 252  TRP A C   1 
ATOM   2085 O O   . TRP A  1 253 ? -11.05184 -6.14032  1.14069   1.000 16.99558 ? 252  TRP A O   1 
ATOM   2086 C CB  . TRP A  1 253 ? -10.77288 -7.11870  -2.07001  1.000 15.10637 ? 252  TRP A CB  1 
ATOM   2087 C CG  . TRP A  1 253 ? -9.35098  -6.67642  -1.82269  1.000 14.39810 ? 252  TRP A CG  1 
ATOM   2088 C CD1 . TRP A  1 253 ? -8.22947  -7.43903  -1.96199  1.000 15.56476 ? 252  TRP A CD1 1 
ATOM   2089 C CD2 . TRP A  1 253 ? -8.90320  -5.37570  -1.40473  1.000 16.76552 ? 252  TRP A CD2 1 
ATOM   2090 N NE1 . TRP A  1 253 ? -7.11159  -6.70128  -1.66304  1.000 16.59581 ? 252  TRP A NE1 1 
ATOM   2091 C CE2 . TRP A  1 253 ? -7.49702  -5.43094  -1.31402  1.000 16.91750 ? 252  TRP A CE2 1 
ATOM   2092 C CE3 . TRP A  1 253 ? -9.55487  -4.16829  -1.10985  1.000 16.41128 ? 252  TRP A CE3 1 
ATOM   2093 C CZ2 . TRP A  1 253 ? -6.72722  -4.32949  -0.94050  1.000 15.40846 ? 252  TRP A CZ2 1 
ATOM   2094 C CZ3 . TRP A  1 253 ? -8.79112  -3.07009  -0.73338  1.000 17.58934 ? 252  TRP A CZ3 1 
ATOM   2095 C CH2 . TRP A  1 253 ? -7.39014  -3.16120  -0.64436  1.000 17.87051 ? 252  TRP A CH2 1 
ATOM   2096 N N   . GLU A  1 254 ? -12.67664 -5.42494  -0.24681  1.000 15.31307 ? 253  GLU A N   1 
ATOM   2097 C CA  . GLU A  1 254 ? -12.89709 -4.22828  0.56184   1.000 18.58902 ? 253  GLU A CA  1 
ATOM   2098 C C   . GLU A  1 254 ? -13.37682 -4.59083  1.95571   1.000 17.68168 ? 253  GLU A C   1 
ATOM   2099 O O   . GLU A  1 254 ? -12.98112 -3.95525  2.94094   1.000 17.92650 ? 253  GLU A O   1 
ATOM   2100 C CB  . GLU A  1 254 ? -13.91731 -3.29319  -0.09216  1.000 17.83993 ? 253  GLU A CB  1 
ATOM   2101 C CG  . GLU A  1 254 ? -13.48572 -2.69393  -1.43349  1.000 17.35018 ? 253  GLU A CG  1 
ATOM   2102 C CD  . GLU A  1 254 ? -12.54864 -1.50347  -1.32142  1.000 22.42937 ? 253  GLU A CD  1 
ATOM   2103 O OE1 . GLU A  1 254 ? -12.19885 -1.07562  -0.19869  1.000 23.65419 ? 253  GLU A OE1 1 
ATOM   2104 O OE2 . GLU A  1 254 ? -12.16364 -0.96228  -2.38105  1.000 19.26374 ? 253  GLU A OE2 1 
ATOM   2105 N N   . GLU A  1 255 ? -14.25924 -5.58527  2.05293   1.000 15.63219 ? 254  GLU A N   1 
ATOM   2106 C CA  . GLU A  1 255 ? -14.76237 -5.98578  3.36530   1.000 15.96646 ? 254  GLU A CA  1 
ATOM   2107 C C   . GLU A  1 255 ? -13.63686 -6.54810  4.22272   1.000 17.50626 ? 254  GLU A C   1 
ATOM   2108 O O   . GLU A  1 255 ? -13.52313 -6.22326  5.41707   1.000 17.07101 ? 254  GLU A O   1 
ATOM   2109 C CB  . GLU A  1 255 ? -15.88402 -7.01082  3.19150   1.000 16.28555 ? 254  GLU A CB  1 
ATOM   2110 C CG  . GLU A  1 255 ? -17.15190 -6.40383  2.56371   1.000 19.87134 ? 254  GLU A CG  1 
ATOM   2111 C CD  . GLU A  1 255 ? -18.08847 -7.43184  1.98531   1.000 25.46719 ? 254  GLU A CD  1 
ATOM   2112 O OE1 . GLU A  1 255 ? -17.74222 -8.63309  1.95462   1.000 20.51562 ? 254  GLU A OE1 1 
ATOM   2113 O OE2 . GLU A  1 255 ? -19.19385 -7.03532  1.55060   1.000 30.71571 ? 254  GLU A OE2 1 
ATOM   2114 N N   . LEU A  1 256 ? -12.80368 -7.40906  3.63233   1.000 15.75950 ? 255  LEU A N   1 
ATOM   2115 C CA  . LEU A  1 256 ? -11.68162 -7.98432  4.37699   1.000 15.70868 ? 255  LEU A CA  1 
ATOM   2116 C C   . LEU A  1 256 ? -10.70542 -6.90077  4.81189   1.000 18.39486 ? 255  LEU A C   1 
ATOM   2117 O O   . LEU A  1 256 ? -10.22581 -6.89981  5.95106   1.000 17.96471 ? 255  LEU A O   1 
ATOM   2118 C CB  . LEU A  1 256 ? -10.97208 -9.03565  3.51114   1.000 16.54083 ? 255  LEU A CB  1 
ATOM   2119 C CG  . LEU A  1 256 ? -11.77545 -10.31234 3.23506   1.000 14.58289 ? 255  LEU A CG  1 
ATOM   2120 C CD1 . LEU A  1 256 ? -11.13458 -11.11740 2.10491   1.000 15.28483 ? 255  LEU A CD1 1 
ATOM   2121 C CD2 . LEU A  1 256 ? -11.91107 -11.18672 4.49470   1.000 16.61982 ? 255  LEU A CD2 1 
ATOM   2122 N N   . THR A  1 257 ? -10.41582 -5.95586  3.91817   1.000 16.70406 ? 256  THR A N   1 
ATOM   2123 C CA  . THR A  1 257 ? -9.43532  -4.92172  4.21674   1.000 19.93552 ? 256  THR A CA  1 
ATOM   2124 C C   . THR A  1 257 ? -9.92233  -4.00802  5.32892   1.000 20.25162 ? 256  THR A C   1 
ATOM   2125 O O   . THR A  1 257 ? -9.14910  -3.65455  6.22271   1.000 19.39361 ? 256  THR A O   1 
ATOM   2126 C CB  . THR A  1 257 ? -9.12951  -4.12164  2.95154   1.000 17.53446 ? 256  THR A CB  1 
ATOM   2127 O OG1 . THR A  1 257 ? -8.56175  -4.99973  1.97406   1.000 17.84482 ? 256  THR A OG1 1 
ATOM   2128 C CG2 . THR A  1 257 ? -8.14137  -2.98990  3.23147   1.000 20.98735 ? 256  THR A CG2 1 
ATOM   2129 N N   . ARG A  1 258 ? -11.20878 -3.64402  5.30520   1.000 19.42254 ? 257  ARG A N   1 
ATOM   2130 C CA  . ARG A  1 258 ? -11.76410 -2.76299  6.33147   1.000 20.19833 ? 257  ARG A CA  1 
ATOM   2131 C C   . ARG A  1 258 ? -11.79012 -3.43979  7.69752   1.000 18.69973 ? 257  ARG A C   1 
ATOM   2132 O O   . ARG A  1 258 ? -11.67717 -2.76603  8.73088   1.000 20.92727 ? 257  ARG A O   1 
ATOM   2133 C CB  . ARG A  1 258 ? -13.17204 -2.33308  5.91546   1.000 18.02058 ? 257  ARG A CB  1 
ATOM   2134 C CG  . ARG A  1 258 ? -13.97146 -1.54095  6.96246   1.000 24.65490 ? 257  ARG A CG  1 
ATOM   2135 C CD  . ARG A  1 258 ? -15.22136 -0.95575  6.29295   1.000 26.78339 ? 257  ARG A CD  1 
ATOM   2136 N NE  . ARG A  1 258 ? -16.13034 -0.27981  7.21457   1.000 31.01877 ? 257  ARG A NE  1 
ATOM   2137 C CZ  . ARG A  1 258 ? -15.93804 0.94248   7.69248   1.000 44.36745 ? 257  ARG A CZ  1 
ATOM   2138 N NH1 . ARG A  1 258 ? -14.86213 1.64552   7.37525   1.000 45.91114 ? 257  ARG A NH1 1 
ATOM   2139 N NH2 . ARG A  1 258 ? -16.84848 1.47309   8.51013   1.000 36.72728 ? 257  ARG A NH2 1 
ATOM   2140 N N   . ALA A  1 259 ? -11.93871 -4.75767  7.72478   1.000 17.35492 ? 258  ALA A N   1 
ATOM   2141 C CA  . ALA A  1 259 ? -12.01208 -5.47810  8.99479   1.000 16.83082 ? 258  ALA A CA  1 
ATOM   2142 C C   . ALA A  1 259 ? -10.64745 -5.87812  9.54105   1.000 18.18433 ? 258  ALA A C   1 
ATOM   2143 O O   . ALA A  1 259 ? -10.47131 -5.96095  10.77077  1.000 17.83343 ? 258  ALA A O   1 
ATOM   2144 C CB  . ALA A  1 259 ? -12.86784 -6.73165  8.82125   1.000 17.57658 ? 258  ALA A CB  1 
ATOM   2145 N N   . PHE A  1 260 ? -9.67524  -6.14639  8.67124   1.000 16.23589 ? 259  PHE A N   1 
ATOM   2146 C CA  . PHE A  1 260 ? -8.44221  -6.83394  9.05951   1.000 19.03913 ? 259  PHE A CA  1 
ATOM   2147 C C   . PHE A  1 260 ? -7.21306  -6.07603  8.57483   1.000 17.52300 ? 259  PHE A C   1 
ATOM   2148 O O   . PHE A  1 260 ? -6.47687  -6.56058  7.70690   1.000 17.34161 ? 259  PHE A O   1 
ATOM   2149 C CB  . PHE A  1 260 ? -8.44608  -8.26952  8.51829   1.000 15.64577 ? 259  PHE A CB  1 
ATOM   2150 C CG  . PHE A  1 260 ? -9.70071  -9.03876  8.85802   1.000 18.41900 ? 259  PHE A CG  1 
ATOM   2151 C CD1 . PHE A  1 260 ? -10.10695 -9.19183  10.18664  1.000 16.55600 ? 259  PHE A CD1 1 
ATOM   2152 C CD2 . PHE A  1 260 ? -10.48451 -9.58912  7.85690   1.000 17.18670 ? 259  PHE A CD2 1 
ATOM   2153 C CE1 . PHE A  1 260 ? -11.27578 -9.89352  10.50106  1.000 17.33748 ? 259  PHE A CE1 1 
ATOM   2154 C CE2 . PHE A  1 260 ? -11.63904 -10.28879 8.15418   1.000 17.89148 ? 259  PHE A CE2 1 
ATOM   2155 C CZ  . PHE A  1 260 ? -12.04689 -10.44209 9.48393   1.000 17.87574 ? 259  PHE A CZ  1 
ATOM   2156 N N   . PRO A  1 261 ? -6.93544  -4.90456  9.14221   1.000 18.48146 ? 260  PRO A N   1 
ATOM   2157 C CA  . PRO A  1 261 ? -5.67078  -4.23560  8.83189   1.000 21.15531 ? 260  PRO A CA  1 
ATOM   2158 C C   . PRO A  1 261 ? -4.49033  -5.14517  9.13673   1.000 23.41084 ? 260  PRO A C   1 
ATOM   2159 O O   . PRO A  1 261 ? -4.48479  -5.88495  10.12680  1.000 18.24661 ? 260  PRO A O   1 
ATOM   2160 C CB  . PRO A  1 261 ? -5.68320  -2.99756  9.73603   1.000 20.88822 ? 260  PRO A CB  1 
ATOM   2161 C CG  . PRO A  1 261 ? -6.65750  -3.32484  10.82140  1.000 27.30488 ? 260  PRO A CG  1 
ATOM   2162 C CD  . PRO A  1 261 ? -7.69408  -4.19202  10.18726  1.000 18.48817 ? 260  PRO A CD  1 
ATOM   2163 N N   . SER A  1 262 ? -3.49267  -5.10179  8.25408   1.000 17.35657 ? 261  SER A N   1 
ATOM   2164 C CA  . SER A  1 262 ? -2.33972  -5.97456  8.38111   1.000 16.71423 ? 261  SER A CA  1 
ATOM   2165 C C   . SER A  1 262 ? -1.11215  -5.27003  7.82030   1.000 23.07164 ? 261  SER A C   1 
ATOM   2166 O O   . SER A  1 262 ? -1.17778  -4.73224  6.69769   1.000 20.25471 ? 261  SER A O   1 
ATOM   2167 C CB  . SER A  1 262 ? -2.56951  -7.29883  7.65136   1.000 17.86551 ? 261  SER A CB  1 
ATOM   2168 O OG  . SER A  1 262 ? -1.50690  -8.21334  7.88328   1.000 18.87926 ? 261  SER A OG  1 
ATOM   2169 N N   . PRO A  1 263 ? 0.01196   -5.25723  8.54566   1.000 19.13877 ? 262  PRO A N   1 
ATOM   2170 C CA  . PRO A  1 263 ? 0.16018   -5.86838  9.87398   1.000 16.55183 ? 262  PRO A CA  1 
ATOM   2171 C C   . PRO A  1 263 ? -0.56849  -5.06592  10.93077  1.000 20.48731 ? 262  PRO A C   1 
ATOM   2172 O O   . PRO A  1 263 ? -1.01243  -3.95362  10.64636  1.000 18.29531 ? 262  PRO A O   1 
ATOM   2173 C CB  . PRO A  1 263 ? 1.67079   -5.84159  10.11266  1.000 21.44990 ? 262  PRO A CB  1 
ATOM   2174 C CG  . PRO A  1 263 ? 2.16652   -4.72116  9.30322   1.000 27.11755 ? 262  PRO A CG  1 
ATOM   2175 C CD  . PRO A  1 263 ? 1.26964   -4.64680  8.07503   1.000 21.87455 ? 262  PRO A CD  1 
ATOM   2176 N N   . PHE A  1 264 ? -0.69499  -5.61266  12.13884  1.000 18.04275 ? 263  PHE A N   1 
ATOM   2177 C CA  . PHE A  1 264 ? -1.44413  -4.94165  13.18559  1.000 16.38338 ? 263  PHE A CA  1 
ATOM   2178 C C   . PHE A  1 264 ? -0.73763  -5.19151  14.50664  1.000 15.90713 ? 263  PHE A C   1 
ATOM   2179 O O   . PHE A  1 264 ? 0.14318   -6.05482  14.61388  1.000 16.98002 ? 263  PHE A O   1 
ATOM   2180 C CB  . PHE A  1 264 ? -2.90440  -5.42501  13.23408  1.000 17.50376 ? 263  PHE A CB  1 
ATOM   2181 C CG  . PHE A  1 264 ? -3.08605  -6.77536  13.88990  1.000 17.55697 ? 263  PHE A CG  1 
ATOM   2182 C CD1 . PHE A  1 264 ? -2.68489  -7.95018  13.23992  1.000 14.96048 ? 263  PHE A CD1 1 
ATOM   2183 C CD2 . PHE A  1 264 ? -3.66865  -6.87270  15.15378  1.000 16.90681 ? 263  PHE A CD2 1 
ATOM   2184 C CE1 . PHE A  1 264 ? -2.84354  -9.19119  13.85004  1.000 15.32247 ? 263  PHE A CE1 1 
ATOM   2185 C CE2 . PHE A  1 264 ? -3.84242  -8.10857  15.76935  1.000 16.40208 ? 263  PHE A CE2 1 
ATOM   2186 C CZ  . PHE A  1 264 ? -3.42971  -9.27055  15.12821  1.000 15.91546 ? 263  PHE A CZ  1 
ATOM   2187 N N   . SER A  1 265 ? -1.12791  -4.41842  15.51654  1.000 15.79985 ? 264  SER A N   1 
ATOM   2188 C CA  . SER A  1 265 ? -0.55716  -4.57021  16.85257  1.000 15.45687 ? 264  SER A CA  1 
ATOM   2189 C C   . SER A  1 265 ? -1.35730  -5.60636  17.62426  1.000 17.68247 ? 264  SER A C   1 
ATOM   2190 O O   . SER A  1 265 ? -2.57757  -5.47340  17.77451  1.000 17.67068 ? 264  SER A O   1 
ATOM   2191 C CB  . SER A  1 265 ? -0.55180  -3.23138  17.58875  1.000 18.07566 ? 264  SER A CB  1 
ATOM   2192 O OG  . SER A  1 265 ? 0.30747   -2.30205  16.93054  1.000 21.26327 ? 264  SER A OG  1 
ATOM   2193 N N   . LEU A  1 266 ? -0.65901  -6.62015  18.13985  1.000 16.80850 ? 265  LEU A N   1 
ATOM   2194 C CA  . LEU A  1 266 ? -1.28763  -7.74745  18.82735  1.000 15.37070 ? 265  LEU A CA  1 
ATOM   2195 C C   . LEU A  1 266 ? -1.56191  -7.33406  20.26985  1.000 18.34021 ? 265  LEU A C   1 
ATOM   2196 O O   . LEU A  1 266 ? -0.69777  -7.41922  21.14080  1.000 19.20500 ? 265  LEU A O   1 
ATOM   2197 C CB  . LEU A  1 266 ? -0.38784  -8.97389  18.74245  1.000 18.23480 ? 265  LEU A CB  1 
ATOM   2198 C CG  . LEU A  1 266 ? -0.96334  -10.32863 19.15567  1.000 20.66685 ? 265  LEU A CG  1 
ATOM   2199 C CD1 . LEU A  1 266 ? -2.01400  -10.78838 18.13925  1.000 19.13149 ? 265  LEU A CD1 1 
ATOM   2200 C CD2 . LEU A  1 266 ? 0.18935   -11.33690 19.29021  1.000 19.38141 ? 265  LEU A CD2 1 
ATOM   2201 N N   . THR A  1 267 ? -2.77801  -6.84932  20.51549  1.000 16.09480 ? 266  THR A N   1 
ATOM   2202 C CA  . THR A  1 267 ? -3.14286  -6.21883  21.78117  1.000 16.99437 ? 266  THR A CA  1 
ATOM   2203 C C   . THR A  1 267 ? -4.45205  -6.79823  22.29060  1.000 17.89124 ? 266  THR A C   1 
ATOM   2204 O O   . THR A  1 267 ? -5.16395  -7.50983  21.57645  1.000 15.96029 ? 266  THR A O   1 
ATOM   2205 C CB  . THR A  1 267 ? -3.31237  -4.70434  21.61757  1.000 17.97796 ? 266  THR A CB  1 
ATOM   2206 O OG1 . THR A  1 267 ? -4.41704  -4.46081  20.72340  1.000 17.40415 ? 266  THR A OG1 1 
ATOM   2207 C CG2 . THR A  1 267 ? -2.03530  -4.06581  21.05493  1.000 16.87918 ? 266  THR A CG2 1 
ATOM   2208 N N   . VAL A  1 268 ? -4.78695  -6.44178  23.53627  1.000 14.54452 ? 267  VAL A N   1 
ATOM   2209 C CA  . VAL A  1 268 ? -6.06429  -6.84533  24.11514  1.000 15.73714 ? 267  VAL A CA  1 
ATOM   2210 C C   . VAL A  1 268 ? -7.20943  -6.20795  23.34139  1.000 16.92796 ? 267  VAL A C   1 
ATOM   2211 O O   . VAL A  1 268 ? -8.20537  -6.86159  23.01532  1.000 15.38909 ? 267  VAL A O   1 
ATOM   2212 C CB  . VAL A  1 268 ? -6.11629  -6.46080  25.60353  1.000 15.86826 ? 267  VAL A CB  1 
ATOM   2213 C CG1 . VAL A  1 268 ? -7.46574  -6.83577  26.19565  1.000 14.68245 ? 267  VAL A CG1 1 
ATOM   2214 C CG2 . VAL A  1 268 ? -4.97376  -7.14003  26.36491  1.000 15.30144 ? 267  VAL A CG2 1 
ATOM   2215 N N   . ASP A  1 269 ? -7.08145  -4.91324  23.05320  1.000 14.57330 ? 268  ASP A N   1 
ATOM   2216 C CA  . ASP A  1 269 ? -8.09166  -4.20796  22.26629  1.000 15.53028 ? 268  ASP A CA  1 
ATOM   2217 C C   . ASP A  1 269 ? -8.29520  -4.87596  20.90803  1.000 16.92687 ? 268  ASP A C   1 
ATOM   2218 O O   . ASP A  1 269 ? -9.43206  -5.00137  20.43348  1.000 16.35159 ? 268  ASP A O   1 
ATOM   2219 C CB  . ASP A  1 269 ? -7.66521  -2.74050  22.11948  1.000 17.15775 ? 268  ASP A CB  1 
ATOM   2220 C CG  . ASP A  1 269 ? -8.39586  -1.99838  21.00544  1.000 16.59434 ? 268  ASP A CG  1 
ATOM   2221 O OD1 . ASP A  1 269 ? -9.62327  -1.76438  21.10911  1.000 19.60075 ? 268  ASP A OD1 1 
ATOM   2222 O OD2 . ASP A  1 269 ? -7.70536  -1.61648  20.04962  1.000 18.52100 ? 268  ASP A OD2 1 
ATOM   2223 N N   . ALA A  1 270 ? -7.21338  -5.33863  20.27574  1.000 17.20021 ? 269  ALA A N   1 
ATOM   2224 C CA  . ALA A  1 270 ? -7.36702  -5.99649  18.97745  1.000 17.23089 ? 269  ALA A CA  1 
ATOM   2225 C C   . ALA A  1 270 ? -8.24200  -7.23751  19.10067  1.000 17.41380 ? 269  ALA A C   1 
ATOM   2226 O O   . ALA A  1 270 ? -9.16093  -7.44466  18.30022  1.000 15.60687 ? 269  ALA A O   1 
ATOM   2227 C CB  . ALA A  1 270 ? -6.00340  -6.36286  18.38023  1.000 16.28211 ? 269  ALA A CB  1 
ATOM   2228 N N   . ALA A  1 271 ? -7.97225  -8.07926  20.10359  1.000 15.41964 ? 270  ALA A N   1 
ATOM   2229 C CA  . ALA A  1 271 ? -8.75695  -9.29938  20.24611  1.000 13.86165 ? 270  ALA A CA  1 
ATOM   2230 C C   . ALA A  1 271 ? -10.21765 -8.97806  20.53551  1.000 17.22982 ? 270  ALA A C   1 
ATOM   2231 O O   . ALA A  1 271 ? -11.12432 -9.61248  19.98415  1.000 15.93758 ? 270  ALA A O   1 
ATOM   2232 C CB  . ALA A  1 271 ? -8.17256  -10.17139 21.35897  1.000 15.93587 ? 270  ALA A CB  1 
ATOM   2233 N N   . VAL A  1 272 ? -10.46876 -8.00941  21.41974  1.000 14.95386 ? 271  VAL A N   1 
ATOM   2234 C CA  . VAL A  1 272 ? -11.85150 -7.66293  21.74197  1.000 15.30539 ? 271  VAL A CA  1 
ATOM   2235 C C   . VAL A  1 272 ? -12.57380 -7.16297  20.49807  1.000 17.13895 ? 271  VAL A C   1 
ATOM   2236 O O   . VAL A  1 272 ? -13.68059 -7.61746  20.17939  1.000 17.17910 ? 271  VAL A O   1 
ATOM   2237 C CB  . VAL A  1 272 ? -11.90344 -6.62253  22.86761  1.000 13.59715 ? 271  VAL A CB  1 
ATOM   2238 C CG1 . VAL A  1 272 ? -13.33007 -6.07878  23.00027  1.000 17.20283 ? 271  VAL A CG1 1 
ATOM   2239 C CG2 . VAL A  1 272 ? -11.42302 -7.25563  24.17580  1.000 13.29115 ? 271  VAL A CG2 1 
ATOM   2240 N N   . GLN A  1 273 ? -11.95063 -6.23215  19.76926  1.000 16.72565 ? 272  GLN A N   1 
ATOM   2241 C CA  . GLN A  1 273 ? -12.60244 -5.67626  18.58452  1.000 15.48049 ? 272  GLN A CA  1 
ATOM   2242 C C   . GLN A  1 273 ? -12.81821 -6.74898  17.52702  1.000 19.19234 ? 272  GLN A C   1 
ATOM   2243 O O   . GLN A  1 273 ? -13.84086 -6.74609  16.83171  1.000 18.33437 ? 272  GLN A O   1 
ATOM   2244 C CB  . GLN A  1 273 ? -11.77629 -4.51568  18.01903  1.000 16.93109 ? 272  GLN A CB  1 
ATOM   2245 C CG  . GLN A  1 273 ? -11.74324 -3.28650  18.92175  1.000 16.60520 ? 272  GLN A CG  1 
ATOM   2246 C CD  . GLN A  1 273 ? -13.13022 -2.84783  19.34033  1.000 23.26484 ? 272  GLN A CD  1 
ATOM   2247 O OE1 . GLN A  1 273 ? -14.01998 -2.69203  18.49858  1.000 24.58444 ? 272  GLN A OE1 1 
ATOM   2248 N NE2 . GLN A  1 273 ? -13.33179 -2.66308  20.63776  1.000 20.19068 ? 272  GLN A NE2 1 
ATOM   2249 N N   . GLN A  1 274 ? -11.87986 -7.69158  17.40627  1.000 16.23414 ? 273  GLN A N   1 
ATOM   2250 C CA  . GLN A  1 274 ? -12.04233 -8.75969  16.42427  1.000 17.35467 ? 273  GLN A CA  1 
ATOM   2251 C C   . GLN A  1 274 ? -13.28344 -9.59407  16.72175  1.000 18.33359 ? 273  GLN A C   1 
ATOM   2252 O O   . GLN A  1 274 ? -13.98748 -10.02725 15.79601  1.000 17.31874 ? 273  GLN A O   1 
ATOM   2253 C CB  . GLN A  1 274 ? -10.78342 -9.62818  16.38272  1.000 14.66257 ? 273  GLN A CB  1 
ATOM   2254 C CG  . GLN A  1 274 ? -9.64253  -8.94663  15.64670  1.000 14.69133 ? 273  GLN A CG  1 
ATOM   2255 C CD  . GLN A  1 274 ? -8.26492  -9.48652  16.01410  1.000 15.40226 ? 273  GLN A CD  1 
ATOM   2256 O OE1 . GLN A  1 274 ? -8.12704  -10.38818 16.84607  1.000 16.56269 ? 273  GLN A OE1 1 
ATOM   2257 N NE2 . GLN A  1 274 ? -7.23783  -8.94639  15.36482  1.000 20.81214 ? 273  GLN A NE2 1 
ATOM   2258 N N   . HIS A  1 275 ? -13.59250 -9.79669  18.00700  1.000 16.59694 ? 274  HIS A N   1 
ATOM   2259 C CA  . HIS A  1 275 ? -14.82588 -10.48740 18.36453  1.000 14.49125 ? 274  HIS A CA  1 
ATOM   2260 C C   . HIS A  1 275 ? -16.04837 -9.62339  18.06859  1.000 17.18969 ? 274  HIS A C   1 
ATOM   2261 O O   . HIS A  1 275 ? -17.04836 -10.12205 17.53708  1.000 18.66218 ? 274  HIS A O   1 
ATOM   2262 C CB  . HIS A  1 275 ? -14.79996 -10.89225 19.84594  1.000 16.19759 ? 274  HIS A CB  1 
ATOM   2263 C CG  . HIS A  1 275 ? -13.94885 -12.09556 20.10836  1.000 14.76726 ? 274  HIS A CG  1 
ATOM   2264 N ND1 . HIS A  1 275 ? -12.57217 -12.05079 20.04196  1.000 14.97341 ? 274  HIS A ND1 1 
ATOM   2265 C CD2 . HIS A  1 275 ? -14.27087 -13.38076 20.38462  1.000 16.80661 ? 274  HIS A CD2 1 
ATOM   2266 C CE1 . HIS A  1 275 ? -12.08307 -13.25545 20.26884  1.000 13.80791 ? 274  HIS A CE1 1 
ATOM   2267 N NE2 . HIS A  1 275 ? -13.09062 -14.08276 20.47449  1.000 16.40546 ? 274  HIS A NE2 1 
ATOM   2268 N N   . LEU A  1 276 ? -15.98809 -8.33134  18.41092  1.000 16.16293 ? 275  LEU A N   1 
ATOM   2269 C CA  . LEU A  1 276 ? -17.14961 -7.46338  18.23596  1.000 16.36019 ? 275  LEU A CA  1 
ATOM   2270 C C   . LEU A  1 276 ? -17.48977 -7.27440  16.75683  1.000 20.11203 ? 275  LEU A C   1 
ATOM   2271 O O   . LEU A  1 276 ? -18.66028 -7.04709  16.42263  1.000 20.84089 ? 275  LEU A O   1 
ATOM   2272 C CB  . LEU A  1 276 ? -16.90329 -6.11014  18.89080  1.000 15.97631 ? 275  LEU A CB  1 
ATOM   2273 C CG  . LEU A  1 276 ? -16.80593 -6.11895  20.42685  1.000 17.45915 ? 275  LEU A CG  1 
ATOM   2274 C CD1 . LEU A  1 276 ? -16.35906 -4.73638  20.88690  1.000 20.35117 ? 275  LEU A CD1 1 
ATOM   2275 C CD2 . LEU A  1 276 ? -18.14000 -6.51253  21.05024  1.000 20.61110 ? 275  LEU A CD2 1 
ATOM   2276 N N   . MET A  1 277 ? -16.48830 -7.32192  15.86827  1.000 18.51698 ? 276  MET A N   1 
ATOM   2277 C CA  . MET A  1 277 ? -16.77294 -7.22574  14.43159  1.000 16.68525 ? 276  MET A CA  1 
ATOM   2278 C C   . MET A  1 277 ? -17.67465 -8.30521  13.86948  1.000 17.76821 ? 276  MET A C   1 
ATOM   2279 O O   . MET A  1 277 ? -18.25309 -8.08918  12.79562  1.000 19.33305 ? 276  MET A O   1 
ATOM   2280 C CB  . MET A  1 277 ? -15.48624 -7.15629  13.57794  1.000 17.26287 ? 276  MET A CB  1 
ATOM   2281 C CG  . MET A  1 277 ? -14.54864 -6.01019  13.83853  1.000 19.34247 ? 276  MET A CG  1 
ATOM   2282 S SD  . MET A  1 277 ? -13.24295 -5.98948  12.54661  1.000 19.09001 ? 276  MET A SD  1 
ATOM   2283 C CE  . MET A  1 277 ? -12.59475 -7.66404  12.71436  1.000 18.76778 ? 276  MET A CE  1 
ATOM   2284 N N   A MET A  1 278 ? -17.79974 -9.44504  14.54302  0.324 18.50472 ? 277  MET A N   1 
ATOM   2285 N N   B MET A  1 278 ? -17.84518 -9.43219  14.54761  0.676 18.48374 ? 277  MET A N   1 
ATOM   2286 C CA  A MET A  1 278 ? -18.63191 -10.52528 14.05410  0.324 18.92497 ? 277  MET A CA  1 
ATOM   2287 C CA  B MET A  1 278 ? -18.59977 -10.53013 13.97155  0.676 18.93226 ? 277  MET A CA  1 
ATOM   2288 C C   A MET A  1 278 ? -20.08820 -10.25991 14.38552  0.324 19.61424 ? 277  MET A C   1 
ATOM   2289 C C   B MET A  1 278 ? -20.06015 -10.43301 14.39245  0.676 19.76409 ? 277  MET A C   1 
ATOM   2290 O O   A MET A  1 278 ? -20.42277 -9.85583  15.50089  0.324 19.11493 ? 277  MET A O   1 
ATOM   2291 O O   B MET A  1 278 ? -20.36437 -10.28868 15.57947  0.676 19.92940 ? 277  MET A O   1 
ATOM   2292 C CB  A MET A  1 278 ? -18.19891 -11.85480 14.66244  0.324 17.18961 ? 277  MET A CB  1 
ATOM   2293 C CB  B MET A  1 278 ? -17.99617 -11.86538 14.38536  0.676 17.17113 ? 277  MET A CB  1 
ATOM   2294 C CG  A MET A  1 278 ? -17.18653 -12.60964 13.83693  0.324 18.71142 ? 277  MET A CG  1 
ATOM   2295 C CG  B MET A  1 278 ? -16.63955 -12.12046 13.71515  0.676 13.96137 ? 277  MET A CG  1 
ATOM   2296 S SD  A MET A  1 278 ? -17.74134 -12.89795 12.14714  0.324 31.20213 ? 277  MET A SD  1 
ATOM   2297 S SD  B MET A  1 278 ? -16.75709 -12.24399 11.90879  0.676 14.27509 ? 277  MET A SD  1 
ATOM   2298 C CE  A MET A  1 278 ? -16.38567 -13.89695 11.58819  0.324 20.15883 ? 277  MET A CE  1 
ATOM   2299 C CE  B MET A  1 278 ? -17.33169 -13.94453 11.77305  0.676 17.94888 ? 277  MET A CE  1 
ATOM   2300 N N   . GLU A  1 279 ? -20.95458 -10.48588 13.40433  1.000 18.60680 ? 278  GLU A N   1 
ATOM   2301 C CA  . GLU A  1 279 ? -22.38187 -10.39728 13.66405  1.000 17.84854 ? 278  GLU A CA  1 
ATOM   2302 C C   . GLU A  1 279 ? -22.79824 -11.52494 14.59160  1.000 19.95884 ? 278  GLU A C   1 
ATOM   2303 O O   . GLU A  1 279 ? -22.35111 -12.66685 14.45164  1.000 24.49374 ? 278  GLU A O   1 
ATOM   2304 C CB  . GLU A  1 279 ? -23.15624 -10.48915 12.34532  1.000 24.78864 ? 278  GLU A CB  1 
ATOM   2305 C CG  . GLU A  1 279 ? -24.57153 -9.94913  12.42352  1.000 42.62272 ? 278  GLU A CG  1 
ATOM   2306 C CD  . GLU A  1 279 ? -25.01925 -9.35448  11.10200  1.000 48.49354 ? 278  GLU A CD  1 
ATOM   2307 O OE1 . GLU A  1 279 ? -24.44221 -9.73792  10.05871  1.000 45.74684 ? 278  GLU A OE1 1 
ATOM   2308 O OE2 . GLU A  1 279 ? -25.92427 -8.49352  11.11020  1.000 74.93974 ? 278  GLU A OE2 1 
ATOM   2309 N N   . GLY A  1 280 ? -23.65137 -11.20579 15.55107  1.000 21.28160 ? 279  GLY A N   1 
ATOM   2310 C CA  . GLY A  1 280 ? -24.14104 -12.22505 16.44744  1.000 19.55537 ? 279  GLY A CA  1 
ATOM   2311 C C   . GLY A  1 280 ? -23.25718 -12.52045 17.64007  1.000 23.37828 ? 279  GLY A C   1 
ATOM   2312 O O   . GLY A  1 280 ? -23.54112 -13.47544 18.36870  1.000 25.53420 ? 279  GLY A O   1 
ATOM   2313 N N   . VAL A  1 281 ? -22.18451 -11.76194 17.84007  1.000 18.23230 ? 280  VAL A N   1 
ATOM   2314 C CA  . VAL A  1 281 ? -21.30771 -11.93311 19.00077  1.000 20.95633 ? 280  VAL A CA  1 
ATOM   2315 C C   . VAL A  1 281 ? -21.53570 -10.75006 19.93579  1.000 18.89488 ? 280  VAL A C   1 
ATOM   2316 O O   . VAL A  1 281 ? -21.01689 -9.65173  19.68835  1.000 22.18442 ? 280  VAL A O   1 
ATOM   2317 C CB  . VAL A  1 281 ? -19.83311 -12.04151 18.58085  1.000 20.43312 ? 280  VAL A CB  1 
ATOM   2318 C CG1 . VAL A  1 281 ? -18.93635 -12.13929 19.82278  1.000 19.10575 ? 280  VAL A CG1 1 
ATOM   2319 C CG2 . VAL A  1 281 ? -19.62690 -13.23787 17.64731  1.000 19.15911 ? 280  VAL A CG2 1 
ATOM   2320 N N   . PRO A  1 282 ? -22.30843 -10.91838 21.00355  1.000 18.20972 ? 281  PRO A N   1 
ATOM   2321 C CA  . PRO A  1 282 ? -22.67801 -9.76956  21.84280  1.000 20.33179 ? 281  PRO A CA  1 
ATOM   2322 C C   . PRO A  1 282 ? -21.56688 -9.37808  22.79840  1.000 20.02864 ? 281  PRO A C   1 
ATOM   2323 O O   . PRO A  1 282 ? -20.88113 -10.23194 23.36496  1.000 16.93024 ? 281  PRO A O   1 
ATOM   2324 C CB  . PRO A  1 282 ? -23.90717 -10.26920 22.61035  1.000 21.66444 ? 281  PRO A CB  1 
ATOM   2325 C CG  . PRO A  1 282 ? -23.75164 -11.77906 22.63569  1.000 21.02569 ? 281  PRO A CG  1 
ATOM   2326 C CD  . PRO A  1 282 ? -22.97201 -12.16842 21.40568  1.000 18.53619 ? 281  PRO A CD  1 
ATOM   2327 N N   . SER A  1 283 ? -21.39885 -8.06396  22.97212  1.000 18.27261 ? 282  SER A N   1 
ATOM   2328 C CA  . SER A  1 283 ? -20.33843 -7.57683  23.84624  1.000 19.99159 ? 282  SER A CA  1 
ATOM   2329 C C   . SER A  1 283 ? -20.47567 -8.13747  25.25447  1.000 20.15015 ? 282  SER A C   1 
ATOM   2330 O O   . SER A  1 283 ? -19.46193 -8.42012  25.90303  1.000 17.75356 ? 282  SER A O   1 
ATOM   2331 C CB  . SER A  1 283 ? -20.32336 -6.04340  23.87745  1.000 18.67105 ? 282  SER A CB  1 
ATOM   2332 O OG  . SER A  1 283 ? -21.46109 -5.49941  24.54259  1.000 19.79250 ? 282  SER A OG  1 
ATOM   2333 N N   . ALA A  1 284 ? -21.71254 -8.34211  25.73245  1.000 19.02853 ? 283  ALA A N   1 
ATOM   2334 C CA  . ALA A  1 284 ? -21.91212 -8.76343  27.11510  1.000 18.21124 ? 283  ALA A CA  1 
ATOM   2335 C C   . ALA A  1 284 ? -21.40001 -10.17465 27.38610  1.000 17.80471 ? 283  ALA A C   1 
ATOM   2336 O O   . ALA A  1 284 ? -21.23771 -10.54241 28.55514  1.000 18.75489 ? 283  ALA A O   1 
ATOM   2337 C CB  . ALA A  1 284 ? -23.39242 -8.67752  27.49463  1.000 20.19451 ? 283  ALA A CB  1 
ATOM   2338 N N   . LYS A  1 285 ? -21.16054 -10.97554 26.34493  1.000 17.11444 ? 284  LYS A N   1 
ATOM   2339 C CA  . LYS A  1 285 ? -20.60833 -12.30791 26.52722  1.000 16.07637 ? 284  LYS A CA  1 
ATOM   2340 C C   . LYS A  1 285 ? -19.08911 -12.32388 26.46592  1.000 17.14181 ? 284  LYS A C   1 
ATOM   2341 O O   . LYS A  1 285 ? -18.48271 -13.33295 26.84477  1.000 17.13950 ? 284  LYS A O   1 
ATOM   2342 C CB  . LYS A  1 285 ? -21.16211 -13.25896 25.46516  1.000 15.26818 ? 284  LYS A CB  1 
ATOM   2343 C CG  . LYS A  1 285 ? -22.60408 -13.65409 25.70896  1.000 16.24409 ? 284  LYS A CG  1 
ATOM   2344 C CD  . LYS A  1 285 ? -23.01155 -14.80006 24.80578  1.000 16.20495 ? 284  LYS A CD  1 
ATOM   2345 C CE  . LYS A  1 285 ? -24.47569 -15.18535 25.04298  1.000 17.74693 ? 284  LYS A CE  1 
ATOM   2346 N NZ  . LYS A  1 285 ? -24.83328 -16.40079 24.23925  1.000 16.47122 ? 284  LYS A NZ  1 
ATOM   2347 N N   . ILE A  1 286 ? -18.46171 -11.23225 26.03248  1.000 15.65243 ? 285  ILE A N   1 
ATOM   2348 C CA  . ILE A  1 286 ? -17.00617 -11.19195 25.89319  1.000 15.35532 ? 285  ILE A CA  1 
ATOM   2349 C C   . ILE A  1 286 ? -16.39334 -10.83449 27.24435  1.000 16.09164 ? 285  ILE A C   1 
ATOM   2350 O O   . ILE A  1 286 ? -16.69903 -9.78304  27.81282  1.000 17.64964 ? 285  ILE A O   1 
ATOM   2351 C CB  . ILE A  1 286 ? -16.58379 -10.17816 24.82450  1.000 15.83292 ? 285  ILE A CB  1 
ATOM   2352 C CG1 . ILE A  1 286 ? -17.12937 -10.57794 23.44678  1.000 15.89264 ? 285  ILE A CG1 1 
ATOM   2353 C CG2 . ILE A  1 286 ? -15.06441 -10.04083 24.77925  1.000 16.02228 ? 285  ILE A CG2 1 
ATOM   2354 C CD1 . ILE A  1 286 ? -16.92094 -9.49195  22.41633  1.000 21.55460 ? 285  ILE A CD1 1 
ATOM   2355 N N   . VAL A  1 287 ? -15.48435 -11.67647 27.73118  1.000 13.76743 ? 286  VAL A N   1 
ATOM   2356 C CA  . VAL A  1 287 ? -14.78988 -11.45054 28.99556  1.000 15.53847 ? 286  VAL A CA  1 
ATOM   2357 C C   . VAL A  1 287 ? -13.30978 -11.27553 28.68322  1.000 18.22068 ? 286  VAL A C   1 
ATOM   2358 O O   . VAL A  1 287 ? -12.73603 -12.06583 27.92585  1.000 16.78629 ? 286  VAL A O   1 
ATOM   2359 C CB  . VAL A  1 287 ? -15.03629 -12.61320 29.97272  1.000 14.67273 ? 286  VAL A CB  1 
ATOM   2360 C CG1 . VAL A  1 287 ? -14.08392 -12.54297 31.17545  1.000 14.60142 ? 286  VAL A CG1 1 
ATOM   2361 C CG2 . VAL A  1 287 ? -16.48453 -12.58973 30.45980  1.000 16.67087 ? 286  VAL A CG2 1 
ATOM   2362 N N   A MET A  1 288 ? -12.70191 -10.23212 29.24643  0.922 15.91295 ? 287  MET A N   1 
ATOM   2363 N N   B MET A  1 288 ? -12.70130 -10.22856 29.23137  0.078 15.92489 ? 287  MET A N   1 
ATOM   2364 C CA  A MET A  1 288 ? -11.29329 -9.93344  29.00682  0.922 14.89997 ? 287  MET A CA  1 
ATOM   2365 C CA  B MET A  1 288 ? -11.29140 -9.96225  28.97794  0.078 14.98574 ? 287  MET A CA  1 
ATOM   2366 C C   A MET A  1 288 ? -10.41745 -10.70273 29.99119  0.922 17.76748 ? 287  MET A C   1 
ATOM   2367 C C   B MET A  1 288 ? -10.44105 -10.72595 29.98396  0.078 17.49236 ? 287  MET A C   1 
ATOM   2368 O O   A MET A  1 288 ? -10.50949 -10.48844 31.20173  0.922 16.23000 ? 287  MET A O   1 
ATOM   2369 O O   B MET A  1 288 ? -10.58341 -10.53824 31.19679  0.078 16.20071 ? 287  MET A O   1 
ATOM   2370 C CB  A MET A  1 288 ? -11.02805 -8.43594  29.14887  0.922 15.74790 ? 287  MET A CB  1 
ATOM   2371 C CB  B MET A  1 288 ? -10.97598 -8.46907  29.04652  0.078 15.79889 ? 287  MET A CB  1 
ATOM   2372 C CG  A MET A  1 288 ? -9.56439  -8.06806  28.90742  0.922 15.02681 ? 287  MET A CG  1 
ATOM   2373 C CG  B MET A  1 288 ? -9.48632  -8.19794  29.21587  0.078 15.10951 ? 287  MET A CG  1 
ATOM   2374 S SD  A MET A  1 288 ? -9.14201  -6.43598  29.54952  0.922 16.93354 ? 287  MET A SD  1 
ATOM   2375 S SD  B MET A  1 288 ? -9.09559  -6.51857  29.72956  0.078 16.73977 ? 287  MET A SD  1 
ATOM   2376 C CE  A MET A  1 288 ? -9.99633  -5.36941  28.39046  0.922 16.89588 ? 287  MET A CE  1 
ATOM   2377 C CE  B MET A  1 288 ? -10.13008 -5.57979  28.60944  0.078 16.73025 ? 287  MET A CE  1 
ATOM   2378 N N   . GLY A  1 289 ? -9.56869  -11.59267 29.47766  1.000 15.13352 ? 288  GLY A N   1 
ATOM   2379 C CA  . GLY A  1 289 ? -8.58926  -12.24283 30.33175  1.000 13.70895 ? 288  GLY A CA  1 
ATOM   2380 C C   . GLY A  1 289 ? -7.44714  -11.29413 30.67307  1.000 15.73330 ? 288  GLY A C   1 
ATOM   2381 O O   . GLY A  1 289 ? -7.03936  -10.45411 29.86496  1.000 16.44627 ? 288  GLY A O   1 
ATOM   2382 N N   . VAL A  1 290 ? -6.94046  -11.42273 31.90070  1.000 14.59728 ? 289  VAL A N   1 
ATOM   2383 C CA  . VAL A  1 290 ? -5.75852  -10.66871 32.31396  1.000 17.21601 ? 289  VAL A CA  1 
ATOM   2384 C C   . VAL A  1 290 ? -4.82337  -11.63408 33.02862  1.000 14.50586 ? 289  VAL A C   1 
ATOM   2385 O O   . VAL A  1 290 ? -5.28951  -12.58655 33.66938  1.000 14.74296 ? 289  VAL A O   1 
ATOM   2386 C CB  . VAL A  1 290 ? -6.09897  -9.46516  33.21833  1.000 15.91601 ? 289  VAL A CB  1 
ATOM   2387 C CG1 . VAL A  1 290 ? -6.96133  -8.43411  32.46908  1.000 15.44216 ? 289  VAL A CG1 1 
ATOM   2388 C CG2 . VAL A  1 290 ? -6.75946  -9.90463  34.54450  1.000 13.72239 ? 289  VAL A CG2 1 
ATOM   2389 N N   . PRO A  1 291 ? -3.50888  -11.43300 32.94105  1.000 14.38199 ? 290  PRO A N   1 
ATOM   2390 C CA  . PRO A  1 291 ? -2.56921  -12.30484 33.65030  1.000 15.05673 ? 290  PRO A CA  1 
ATOM   2391 C C   . PRO A  1 291 ? -2.23574  -11.77083 35.03456  1.000 14.99734 ? 290  PRO A C   1 
ATOM   2392 O O   . PRO A  1 291 ? -2.00542  -10.57447 35.22816  1.000 16.51664 ? 290  PRO A O   1 
ATOM   2393 C CB  . PRO A  1 291 ? -1.32772  -12.25977 32.74975  1.000 14.31359 ? 290  PRO A CB  1 
ATOM   2394 C CG  . PRO A  1 291 ? -1.35226  -10.84434 32.17862  1.000 16.45199 ? 290  PRO A CG  1 
ATOM   2395 C CD  . PRO A  1 291 ? -2.81771  -10.40700 32.13937  1.000 16.01437 ? 290  PRO A CD  1 
ATOM   2396 N N   . PHE A  1 292 ? -2.20687  -12.67765 36.01025  1.000 14.28144 ? 291  PHE A N   1 
ATOM   2397 C CA  . PHE A  1 292 ? -1.69358  -12.34271 37.33636  1.000 13.54327 ? 291  PHE A CA  1 
ATOM   2398 C C   . PHE A  1 292 ? -0.21487  -12.70668 37.46998  1.000 15.11568 ? 291  PHE A C   1 
ATOM   2399 O O   . PHE A  1 292 ? 0.30339   -12.82156 38.58975  1.000 16.77599 ? 291  PHE A O   1 
ATOM   2400 C CB  . PHE A  1 292 ? -2.52494  -13.02514 38.43783  1.000 14.26044 ? 291  PHE A CB  1 
ATOM   2401 C CG  . PHE A  1 292 ? -3.80455  -12.27630 38.82075  1.000 14.60738 ? 291  PHE A CG  1 
ATOM   2402 C CD1 . PHE A  1 292 ? -4.42497  -11.39311 37.93497  1.000 15.69944 ? 291  PHE A CD1 1 
ATOM   2403 C CD2 . PHE A  1 292 ? -4.38407  -12.48318 40.06784  1.000 15.70678 ? 291  PHE A CD2 1 
ATOM   2404 C CE1 . PHE A  1 292 ? -5.60153  -10.72077 38.29046  1.000 16.27742 ? 291  PHE A CE1 1 
ATOM   2405 C CE2 . PHE A  1 292 ? -5.55458  -11.81541 40.44105  1.000 18.08360 ? 291  PHE A CE2 1 
ATOM   2406 C CZ  . PHE A  1 292 ? -6.16439  -10.93032 39.54541  1.000 16.11759 ? 291  PHE A CZ  1 
ATOM   2407 N N   . TYR A  1 293 ? 0.46464   -12.89168 36.34147  1.000 14.95531 ? 292  TYR A N   1 
ATOM   2408 C CA  . TYR A  1 293 ? 1.86222   -13.27959 36.29394  1.000 14.94772 ? 292  TYR A CA  1 
ATOM   2409 C C   . TYR A  1 293 ? 2.54317   -12.45346 35.21352  1.000 15.96754 ? 292  TYR A C   1 
ATOM   2410 O O   . TYR A  1 293 ? 1.89870   -11.92551 34.30039  1.000 16.26638 ? 292  TYR A O   1 
ATOM   2411 C CB  . TYR A  1 293 ? 2.02310   -14.77819 35.97705  1.000 15.38059 ? 292  TYR A CB  1 
ATOM   2412 C CG  . TYR A  1 293 ? 1.41787   -15.09885 34.62114  1.000 14.11633 ? 292  TYR A CG  1 
ATOM   2413 C CD1 . TYR A  1 293 ? 0.06917   -15.39297 34.51146  1.000 15.90275 ? 292  TYR A CD1 1 
ATOM   2414 C CD2 . TYR A  1 293 ? 2.18914   -15.06230 33.45999  1.000 12.83319 ? 292  TYR A CD2 1 
ATOM   2415 C CE1 . TYR A  1 293 ? -0.52003  -15.64674 33.27311  1.000 15.65013 ? 292  TYR A CE1 1 
ATOM   2416 C CE2 . TYR A  1 293 ? 1.61217   -15.32702 32.21135  1.000 14.26715 ? 292  TYR A CE2 1 
ATOM   2417 C CZ  . TYR A  1 293 ? 0.26218   -15.61535 32.14080  1.000 18.53683 ? 292  TYR A CZ  1 
ATOM   2418 O OH  . TYR A  1 293 ? -0.32258  -15.86566 30.91918  1.000 17.05486 ? 292  TYR A OH  1 
ATOM   2419 N N   . GLY A  1 294 ? 3.86329   -12.35813 35.32122  1.000 14.58955 ? 293  GLY A N   1 
ATOM   2420 C CA  . GLY A  1 294 ? 4.65478   -11.71663 34.29920  1.000 15.08002 ? 293  GLY A CA  1 
ATOM   2421 C C   . GLY A  1 294 ? 5.48102   -12.73450 33.54096  1.000 14.43699 ? 293  GLY A C   1 
ATOM   2422 O O   . GLY A  1 294 ? 5.73231   -13.84290 34.03698  1.000 15.29729 ? 293  GLY A O   1 
ATOM   2423 N N   . ARG A  1 295 ? 5.88128   -12.37149 32.32838  1.000 14.51127 ? 294  ARG A N   1 
ATOM   2424 C CA  . ARG A  1 295 ? 6.78729   -13.16792 31.51841  1.000 14.37398 ? 294  ARG A CA  1 
ATOM   2425 C C   . ARG A  1 295 ? 8.14660   -12.48271 31.48342  1.000 15.80296 ? 294  ARG A C   1 
ATOM   2426 O O   . ARG A  1 295 ? 8.23705   -11.29065 31.15908  1.000 16.68016 ? 294  ARG A O   1 
ATOM   2427 C CB  . ARG A  1 295 ? 6.22226   -13.33723 30.10244  1.000 16.41188 ? 294  ARG A CB  1 
ATOM   2428 C CG  . ARG A  1 295 ? 5.08918   -14.34921 30.08009  1.000 16.41701 ? 294  ARG A CG  1 
ATOM   2429 C CD  . ARG A  1 295 ? 4.75401   -14.79420 28.65689  1.000 15.21125 ? 294  ARG A CD  1 
ATOM   2430 N NE  . ARG A  1 295 ? 3.87236   -15.95355 28.69782  1.000 17.03363 ? 294  ARG A NE  1 
ATOM   2431 C CZ  . ARG A  1 295 ? 4.29557   -17.20930 28.75307  1.000 22.21548 ? 294  ARG A CZ  1 
ATOM   2432 N NH1 . ARG A  1 295 ? 5.58597   -17.50185 28.75249  1.000 21.37870 ? 294  ARG A NH1 1 
ATOM   2433 N NH2 . ARG A  1 295 ? 3.40066   -18.19541 28.79650  1.000 21.56512 ? 294  ARG A NH2 1 
ATOM   2434 N N   . ALA A  1 296 ? 9.19282   -13.23871 31.81414  1.000 15.18036 ? 295  ALA A N   1 
ATOM   2435 C CA  . ALA A  1 296 ? 10.54083  -12.71037 31.95578  1.000 13.74367 ? 295  ALA A CA  1 
ATOM   2436 C C   . ALA A  1 296 ? 11.42653  -13.18255 30.81155  1.000 16.64840 ? 295  ALA A C   1 
ATOM   2437 O O   . ALA A  1 296 ? 11.33820  -14.33640 30.37782  1.000 17.81713 ? 295  ALA A O   1 
ATOM   2438 C CB  . ALA A  1 296 ? 11.15198  -13.14156 33.29088  1.000 13.24617 ? 295  ALA A CB  1 
ATOM   2439 N N   . PHE A  1 297 ? 12.29456  -12.28355 30.36230  1.000 14.74572 ? 296  PHE A N   1 
ATOM   2440 C CA  . PHE A  1 297 ? 13.23818  -12.50134 29.27383  1.000 14.47793 ? 296  PHE A CA  1 
ATOM   2441 C C   . PHE A  1 297 ? 14.63086  -12.10686 29.74487  1.000 17.86129 ? 296  PHE A C   1 
ATOM   2442 O O   . PHE A  1 297 ? 14.78860  -11.15370 30.50780  1.000 18.27105 ? 296  PHE A O   1 
ATOM   2443 C CB  . PHE A  1 297 ? 12.91047  -11.62998 28.06126  1.000 13.36957 ? 296  PHE A CB  1 
ATOM   2444 C CG  . PHE A  1 297 ? 11.55969  -11.87441 27.45770  1.000 15.41400 ? 296  PHE A CG  1 
ATOM   2445 C CD1 . PHE A  1 297 ? 10.40287  -11.41397 28.07659  1.000 16.01891 ? 296  PHE A CD1 1 
ATOM   2446 C CD2 . PHE A  1 297 ? 11.45716  -12.51346 26.22913  1.000 18.55444 ? 296  PHE A CD2 1 
ATOM   2447 C CE1 . PHE A  1 297 ? 9.15184   -11.60462 27.47515  1.000 18.16592 ? 296  PHE A CE1 1 
ATOM   2448 C CE2 . PHE A  1 297 ? 10.21717  -12.70998 25.61522  1.000 16.54324 ? 296  PHE A CE2 1 
ATOM   2449 C CZ  . PHE A  1 297 ? 9.06199   -12.25864 26.24210  1.000 17.78942 ? 296  PHE A CZ  1 
ATOM   2450 N N   A LYS A  1 298 ? 15.64184  -12.83495 29.27885  0.657 15.38597 ? 297  LYS A N   1 
ATOM   2451 N N   B LYS A  1 298 ? 15.64235  -12.82635 29.26448  0.343 15.45202 ? 297  LYS A N   1 
ATOM   2452 C CA  A LYS A  1 298 ? 17.02591  -12.49304 29.56937  0.657 16.31457 ? 297  LYS A CA  1 
ATOM   2453 C CA  B LYS A  1 298 ? 17.02925  -12.51229 29.57210  0.343 16.34765 ? 297  LYS A CA  1 
ATOM   2454 C C   A LYS A  1 298 ? 17.75557  -12.15158 28.27707  0.657 17.42613 ? 297  LYS A C   1 
ATOM   2455 C C   B LYS A  1 298 ? 17.81167  -12.29132 28.28374  0.343 17.33812 ? 297  LYS A C   1 
ATOM   2456 O O   A LYS A  1 298 ? 17.20877  -12.26319 27.17545  0.657 16.93380 ? 297  LYS A O   1 
ATOM   2457 O O   B LYS A  1 298 ? 17.35399  -12.63294 27.18966  0.343 16.82268 ? 297  LYS A O   1 
ATOM   2458 C CB  A LYS A  1 298 ? 17.73518  -13.63098 30.31924  0.657 17.40178 ? 297  LYS A CB  1 
ATOM   2459 C CB  B LYS A  1 298 ? 17.67515  -13.62123 30.41278  0.343 17.34165 ? 297  LYS A CB  1 
ATOM   2460 C CG  A LYS A  1 298 ? 17.91697  -14.93337 29.51355  0.657 17.56753 ? 297  LYS A CG  1 
ATOM   2461 C CG  B LYS A  1 298 ? 18.22168  -14.79078 29.60551  0.343 19.62107 ? 297  LYS A CG  1 
ATOM   2462 C CD  A LYS A  1 298 ? 18.95125  -15.82396 30.21973  0.657 19.87244 ? 297  LYS A CD  1 
ATOM   2463 C CD  B LYS A  1 298 ? 19.44368  -15.37341 30.30062  0.343 21.86823 ? 297  LYS A CD  1 
ATOM   2464 C CE  A LYS A  1 298 ? 19.10186  -17.17904 29.56113  0.657 21.24124 ? 297  LYS A CE  1 
ATOM   2465 C CE  B LYS A  1 298 ? 19.79258  -16.74500 29.76432  0.343 21.70249 ? 297  LYS A CE  1 
ATOM   2466 N NZ  A LYS A  1 298 ? 19.96218  -17.12701 28.32829  0.657 25.89722 ? 297  LYS A NZ  1 
ATOM   2467 N NZ  B LYS A  1 298 ? 20.61051  -16.64981 28.52970  0.343 22.59165 ? 297  LYS A NZ  1 
ATOM   2468 N N   . GLY A  1 299 ? 18.99701  -11.69938 28.42219  1.000 16.06728 ? 298  GLY A N   1 
ATOM   2469 C CA  . GLY A  1 299 ? 19.79165  -11.34025 27.25435  1.000 17.12171 ? 298  GLY A CA  1 
ATOM   2470 C C   . GLY A  1 299 ? 19.26084  -10.17110 26.45074  1.000 17.62935 ? 298  GLY A C   1 
ATOM   2471 O O   . GLY A  1 299 ? 19.47254  -10.12396 25.22558  1.000 19.28520 ? 298  GLY A O   1 
ATOM   2472 N N   . VAL A  1 300 ? 18.56582  -9.20271  27.10134  1.000 18.59373 ? 299  VAL A N   1 
ATOM   2473 C CA  . VAL A  1 300 ? 17.99477  -8.07533  26.37023  1.000 19.49190 ? 299  VAL A CA  1 
ATOM   2474 C C   . VAL A  1 300 ? 18.98302  -6.91467  26.36181  1.000 26.11680 ? 299  VAL A C   1 
ATOM   2475 O O   . VAL A  1 300 ? 19.79508  -6.74593  27.27489  1.000 28.68184 ? 299  VAL A O   1 
ATOM   2476 C CB  . VAL A  1 300 ? 16.62086  -7.64035  26.93414  1.000 20.91647 ? 299  VAL A CB  1 
ATOM   2477 C CG1 . VAL A  1 300 ? 15.75345  -8.85643  27.21892  1.000 24.01690 ? 299  VAL A CG1 1 
ATOM   2478 C CG2 . VAL A  1 300 ? 16.78440  -6.79528  28.18952  1.000 26.26592 ? 299  VAL A CG2 1 
ATOM   2479 N N   A SER A  1 301 ? 18.84340  -6.05187  25.35917  0.546 30.32644 ? 300  SER A N   1 
ATOM   2480 N N   B SER A  1 301 ? 18.96408  -6.16169  25.26514  0.454 30.13639 ? 300  SER A N   1 
ATOM   2481 C CA  A SER A  1 301 ? 19.64792  -4.84813  25.21021  0.546 29.72426 ? 300  SER A CA  1 
ATOM   2482 C CA  B SER A  1 301 ? 19.89489  -5.06890  25.01288  0.454 29.09768 ? 300  SER A CA  1 
ATOM   2483 C C   A SER A  1 301 ? 18.98461  -3.64499  25.88346  0.546 36.65817 ? 300  SER A C   1 
ATOM   2484 C C   B SER A  1 301 ? 19.17821  -3.74639  25.24054  0.454 40.25797 ? 300  SER A C   1 
ATOM   2485 O O   A SER A  1 301 ? 17.79256  -3.64139  26.19360  0.546 24.84882 ? 300  SER A O   1 
ATOM   2486 O O   B SER A  1 301 ? 18.13465  -3.48813  24.62962  0.454 44.04864 ? 300  SER A O   1 
ATOM   2487 C CB  A SER A  1 301 ? 19.85806  -4.52920  23.73624  0.546 36.72362 ? 300  SER A CB  1 
ATOM   2488 C CB  B SER A  1 301 ? 20.44699  -5.13688  23.58547  0.454 38.05336 ? 300  SER A CB  1 
ATOM   2489 O OG  A SER A  1 301 ? 18.75021  -3.78524  23.25865  0.546 37.97761 ? 300  SER A OG  1 
ATOM   2490 O OG  B SER A  1 301 ? 21.01970  -6.40612  23.31299  0.454 30.67326 ? 300  SER A OG  1 
ATOM   2491 N N   A GLY A  1 302 ? 19.77269  -2.59144  26.06806  0.546 41.72783 ? 301  GLY A N   1 
ATOM   2492 N N   B GLY A  1 302 ? 19.75102  -2.91008  26.10504  0.454 41.72793 ? 301  GLY A N   1 
ATOM   2493 C CA  A GLY A  1 302 ? 19.26001  -1.33696  26.57420  0.546 41.63778 ? 301  GLY A CA  1 
ATOM   2494 C CA  B GLY A  1 302 ? 19.09425  -1.71250  26.59426  0.454 41.59590 ? 301  GLY A CA  1 
ATOM   2495 C C   A GLY A  1 302 ? 18.61470  -0.50798  25.48033  0.546 42.23233 ? 301  GLY A C   1 
ATOM   2496 C C   B GLY A  1 302 ? 18.76018  -0.64883  25.56783  0.454 42.18192 ? 301  GLY A C   1 
ATOM   2497 O O   A GLY A  1 302 ? 18.29414  -0.99142  24.39042  0.546 40.22010 ? 301  GLY A O   1 
ATOM   2498 O O   B GLY A  1 302 ? 18.85514  -0.86849  24.35582  0.454 42.07341 ? 301  GLY A O   1 
ATOM   2499 N N   A GLY A  1 303 ? 18.41480  0.76871   25.78921  0.546 41.20579 ? 302  GLY A N   1 
ATOM   2500 N N   B GLY A  1 303 ? 18.36112  0.52080   26.05871  0.454 41.08764 ? 302  GLY A N   1 
ATOM   2501 C CA  A GLY A  1 303 ? 17.85895  1.68627   24.81722  0.546 42.65356 ? 302  GLY A CA  1 
ATOM   2502 C CA  B GLY A  1 303 ? 17.93524  1.60357   25.19779  0.454 42.25724 ? 302  GLY A CA  1 
ATOM   2503 C C   A GLY A  1 303 ? 16.40935  2.03383   25.07310  0.546 40.59267 ? 302  GLY A C   1 
ATOM   2504 C C   B GLY A  1 303 ? 16.49845  1.99887   25.45895  0.454 39.56427 ? 302  GLY A C   1 
ATOM   2505 O O   A GLY A  1 303 ? 16.02591  3.20473   24.99594  0.546 43.60597 ? 302  GLY A O   1 
ATOM   2506 O O   B GLY A  1 303 ? 16.20810  3.16604   25.73685  0.454 41.02519 ? 302  GLY A O   1 
ATOM   2507 N N   . ASN A  1 304 ? 15.59275  1.02770   25.37796  1.000 26.39124 ? 303  ASN A N   1 
ATOM   2508 C CA  . ASN A  1 304 ? 14.16790  1.23370   25.60366  1.000 26.58135 ? 303  ASN A CA  1 
ATOM   2509 C C   . ASN A  1 304 ? 13.66275  0.35169   26.74030  1.000 24.94007 ? 303  ASN A C   1 
ATOM   2510 O O   . ASN A  1 304 ? 12.58292  -0.24569  26.65521  1.000 21.88350 ? 303  ASN A O   1 
ATOM   2511 C CB  . ASN A  1 304 ? 13.37010  0.98167   24.32435  1.000 28.45527 ? 303  ASN A CB  1 
ATOM   2512 C CG  . ASN A  1 304 ? 12.03220  1.69105   24.33102  1.000 32.75792 ? 303  ASN A CG  1 
ATOM   2513 O OD1 . ASN A  1 304 ? 11.73678  2.47892   25.23944  1.000 32.10659 ? 303  ASN A OD1 1 
ATOM   2514 N ND2 . ASN A  1 304 ? 11.19815  1.39318   23.34234  1.000 31.99242 ? 303  ASN A ND2 1 
ATOM   2515 N N   . GLY A  1 305 ? 14.43991  0.26428   27.82062  1.000 20.34121 ? 304  GLY A N   1 
ATOM   2516 C CA  . GLY A  1 305 ? 14.01848  -0.47013  29.00051  1.000 20.67407 ? 304  GLY A CA  1 
ATOM   2517 C C   . GLY A  1 305 ? 13.79731  -1.94446  28.76326  1.000 20.13862 ? 304  GLY A C   1 
ATOM   2518 O O   . GLY A  1 305 ? 13.01590  -2.57061  29.48527  1.000 20.66736 ? 304  GLY A O   1 
ATOM   2519 N N   . GLY A  1 306 ? 14.47098  -2.52354  27.76782  1.000 19.31094 ? 305  GLY A N   1 
ATOM   2520 C CA  . GLY A  1 306 ? 14.30304  -3.93021  27.46905  1.000 20.96158 ? 305  GLY A CA  1 
ATOM   2521 C C   . GLY A  1 306 ? 13.16120  -4.23978  26.52192  1.000 21.20757 ? 305  GLY A C   1 
ATOM   2522 O O   . GLY A  1 306 ? 12.99358  -5.40693  26.14572  1.000 19.08768 ? 305  GLY A O   1 
ATOM   2523 N N   . GLN A  1 307 ? 12.37507  -3.23613  26.13249  1.000 18.33441 ? 306  GLN A N   1 
ATOM   2524 C CA  . GLN A  1 307 ? 11.25754  -3.43806  25.22071  1.000 19.08431 ? 306  GLN A CA  1 
ATOM   2525 C C   . GLN A  1 307 ? 11.75559  -3.62151  23.79580  1.000 19.13412 ? 306  GLN A C   1 
ATOM   2526 O O   . GLN A  1 307 ? 12.63849  -2.89021  23.33441  1.000 20.70182 ? 306  GLN A O   1 
ATOM   2527 C CB  . GLN A  1 307 ? 10.31436  -2.23707  25.23849  1.000 18.86890 ? 306  GLN A CB  1 
ATOM   2528 C CG  . GLN A  1 307 ? 9.67938   -1.90078  26.57869  1.000 17.93778 ? 306  GLN A CG  1 
ATOM   2529 C CD  . GLN A  1 307 ? 8.88840   -0.62842  26.46158  1.000 19.95758 ? 306  GLN A CD  1 
ATOM   2530 O OE1 . GLN A  1 307 ? 7.65567   -0.64738  26.37687  1.000 19.73484 ? 306  GLN A OE1 1 
ATOM   2531 N NE2 . GLN A  1 307 ? 9.59945   0.50091   26.41139  1.000 22.54582 ? 306  GLN A NE2 1 
ATOM   2532 N N   . TYR A  1 308 ? 11.14753  -4.57267  23.08671  1.000 15.13805 ? 307  TYR A N   1 
ATOM   2533 C CA  . TYR A  1 308 ? 11.32021  -4.70156  21.63267  1.000 16.60020 ? 307  TYR A CA  1 
ATOM   2534 C C   . TYR A  1 308 ? 12.76383  -5.03972  21.29047  1.000 21.28457 ? 307  TYR A C   1 
ATOM   2535 O O   . TYR A  1 308 ? 13.31074  -4.61222  20.26831  1.000 20.29114 ? 307  TYR A O   1 
ATOM   2536 C CB  . TYR A  1 308 ? 10.85500  -3.43707  20.90601  1.000 19.31834 ? 307  TYR A CB  1 
ATOM   2537 C CG  . TYR A  1 308 ? 9.58456   -2.84936  21.49743  1.000 17.00572 ? 307  TYR A CG  1 
ATOM   2538 C CD1 . TYR A  1 308 ? 8.55675   -3.67625  21.95005  1.000 17.45179 ? 307  TYR A CD1 1 
ATOM   2539 C CD2 . TYR A  1 308 ? 9.41534   -1.47892  21.60261  1.000 18.26717 ? 307  TYR A CD2 1 
ATOM   2540 C CE1 . TYR A  1 308 ? 7.40041   -3.15230  22.48721  1.000 18.64509 ? 307  TYR A CE1 1 
ATOM   2541 C CE2 . TYR A  1 308 ? 8.24738   -0.93742  22.14068  1.000 18.31624 ? 307  TYR A CE2 1 
ATOM   2542 C CZ  . TYR A  1 308 ? 7.24685   -1.78551  22.57894  1.000 19.94555 ? 307  TYR A CZ  1 
ATOM   2543 O OH  . TYR A  1 308 ? 6.09240   -1.27016  23.12284  1.000 19.39848 ? 307  TYR A OH  1 
ATOM   2544 N N   . SER A  1 309 ? 13.36913  -5.85023  22.14249  1.000 17.98795 ? 308  SER A N   1 
ATOM   2545 C CA  . SER A  1 309 ? 14.76445  -6.22342  22.04625  1.000 19.17448 ? 308  SER A CA  1 
ATOM   2546 C C   . SER A  1 309 ? 14.88170  -7.69053  21.66812  1.000 20.73867 ? 308  SER A C   1 
ATOM   2547 O O   . SER A  1 309 ? 13.99609  -8.49922  21.95829  1.000 18.82655 ? 308  SER A O   1 
ATOM   2548 C CB  . SER A  1 309 ? 15.45897  -5.97717  23.39751  1.000 21.04368 ? 308  SER A CB  1 
ATOM   2549 O OG  . SER A  1 309 ? 16.75091  -6.55159  23.44234  1.000 19.78393 ? 308  SER A OG  1 
ATOM   2550 N N   . SER A  1 310 ? 15.98180  -8.03871  21.01393  1.000 17.42827 ? 309  SER A N   1 
ATOM   2551 C CA  A SER A  1 310 ? 16.32063  -9.44665  20.93921  0.760 20.05121 ? 309  SER A CA  1 
ATOM   2552 C CA  B SER A  1 310 ? 16.36348  -9.43878  20.93856  0.240 20.25869 ? 309  SER A CA  1 
ATOM   2553 C C   . SER A  1 310 ? 16.59812  -9.97273  22.34794  1.000 19.69136 ? 309  SER A C   1 
ATOM   2554 O O   . SER A  1 310 ? 16.78956  -9.21397  23.29738  1.000 20.12690 ? 309  SER A O   1 
ATOM   2555 C CB  A SER A  1 310 ? 17.52411  -9.65475  20.02598  0.760 25.94923 ? 309  SER A CB  1 
ATOM   2556 C CB  B SER A  1 310 ? 17.62073  -9.60776  20.08857  0.240 25.83361 ? 309  SER A CB  1 
ATOM   2557 O OG  A SER A  1 310 ? 18.62197  -8.93914  20.53854  0.760 24.49491 ? 309  SER A OG  1 
ATOM   2558 O OG  B SER A  1 310 ? 17.35648  -9.31578  18.73242  0.240 27.10631 ? 309  SER A OG  1 
ATOM   2559 N N   . HIS A  1 311 ? 16.58564  -11.29161 22.48610  1.000 16.78588 ? 310  HIS A N   1 
ATOM   2560 C CA  . HIS A  1 311 ? 16.71528  -11.88438 23.81196  1.000 16.85488 ? 310  HIS A CA  1 
ATOM   2561 C C   . HIS A  1 311 ? 17.24253  -13.30111 23.65829  1.000 18.88835 ? 310  HIS A C   1 
ATOM   2562 O O   . HIS A  1 311 ? 17.24563  -13.86672 22.56470  1.000 18.84845 ? 310  HIS A O   1 
ATOM   2563 C CB  . HIS A  1 311 ? 15.37098  -11.89043 24.55540  1.000 19.36338 ? 310  HIS A CB  1 
ATOM   2564 C CG  . HIS A  1 311 ? 14.37815  -12.83022 23.95025  1.000 16.97805 ? 310  HIS A CG  1 
ATOM   2565 N ND1 . HIS A  1 311 ? 14.27595  -14.14798 24.33716  1.000 16.59588 ? 310  HIS A ND1 1 
ATOM   2566 C CD2 . HIS A  1 311 ? 13.48900  -12.66085 22.94131  1.000 19.25943 ? 310  HIS A CD2 1 
ATOM   2567 C CE1 . HIS A  1 311 ? 13.34911  -14.74631 23.60863  1.000 18.15310 ? 310  HIS A CE1 1 
ATOM   2568 N NE2 . HIS A  1 311 ? 12.85551  -13.86331 22.75595  1.000 16.99289 ? 310  HIS A NE2 1 
ATOM   2569 N N   A SER A  1 312 ? 17.67344  -13.88222 24.77536  0.708 17.48259 ? 311  SER A N   1 
ATOM   2570 N N   B SER A  1 312 ? 17.66791  -13.87865 24.77621  0.292 17.51909 ? 311  SER A N   1 
ATOM   2571 C CA  A SER A  1 312 ? 18.23909  -15.22728 24.76903  0.708 17.76981 ? 311  SER A CA  1 
ATOM   2572 C CA  B SER A  1 312 ? 18.24233  -15.21732 24.79285  0.292 17.78058 ? 311  SER A CA  1 
ATOM   2573 C C   A SER A  1 312 ? 17.47265  -16.15696 25.70303  0.708 18.26558 ? 311  SER A C   1 
ATOM   2574 C C   B SER A  1 312 ? 17.47245  -16.13085 25.73765  0.292 18.25970 ? 311  SER A C   1 
ATOM   2575 O O   A SER A  1 312 ? 18.05659  -16.97958 26.41160  0.708 18.00943 ? 311  SER A O   1 
ATOM   2576 O O   B SER A  1 312 ? 18.05590  -16.91137 26.49344  0.292 18.08343 ? 311  SER A O   1 
ATOM   2577 C CB  A SER A  1 312 ? 19.72491  -15.19459 25.12924  0.708 18.71410 ? 311  SER A CB  1 
ATOM   2578 C CB  B SER A  1 312 ? 19.71926  -15.16288 25.17366  0.292 18.70139 ? 311  SER A CB  1 
ATOM   2579 O OG  A SER A  1 312 ? 19.93621  -14.74369 26.45846  0.708 16.08235 ? 311  SER A OG  1 
ATOM   2580 O OG  B SER A  1 312 ? 20.37734  -14.11293 24.48637  0.292 16.89114 ? 311  SER A OG  1 
ATOM   2581 N N   . THR A  1 313 ? 16.14382  -16.04642 25.70316  1.000 16.33105 ? 312  THR A N   1 
ATOM   2582 C CA  . THR A  1 313 ? 15.31393  -16.81812 26.62057  1.000 15.67645 ? 312  THR A CA  1 
ATOM   2583 C C   . THR A  1 313 ? 14.93156  -18.14440 25.98507  1.000 16.71717 ? 312  THR A C   1 
ATOM   2584 O O   . THR A  1 313 ? 14.26552  -18.14263 24.94078  1.000 17.90683 ? 312  THR A O   1 
ATOM   2585 C CB  . THR A  1 313 ? 14.05245  -16.05614 26.98148  1.000 17.12296 ? 312  THR A CB  1 
ATOM   2586 O OG1 . THR A  1 313 ? 14.36603  -14.67359 27.21588  1.000 18.62576 ? 312  THR A OG1 1 
ATOM   2587 C CG2 . THR A  1 313 ? 13.41470  -16.65938 28.23466  1.000 16.39308 ? 312  THR A CG2 1 
ATOM   2588 N N   . PRO A  1 314 ? 15.30906  -19.28073 26.56912  1.000 17.69957 ? 313  PRO A N   1 
ATOM   2589 C CA  . PRO A  1 314 ? 14.88533  -20.57383 26.01231  1.000 18.64473 ? 313  PRO A CA  1 
ATOM   2590 C C   . PRO A  1 314 ? 13.37057  -20.67543 25.94425  1.000 21.09118 ? 313  PRO A C   1 
ATOM   2591 O O   . PRO A  1 314 ? 12.66298  -20.22590 26.84846  1.000 17.86800 ? 313  PRO A O   1 
ATOM   2592 C CB  . PRO A  1 314 ? 15.45267  -21.59341 27.01155  1.000 22.01602 ? 313  PRO A CB  1 
ATOM   2593 C CG  . PRO A  1 314 ? 16.58445  -20.88275 27.68180  1.000 23.21551 ? 313  PRO A CG  1 
ATOM   2594 C CD  . PRO A  1 314 ? 16.18370  -19.43815 27.74453  1.000 17.45255 ? 313  PRO A CD  1 
ATOM   2595 N N   . GLY A  1 315 ? 12.87941  -21.30153 24.87517  1.000 22.40095 ? 314  GLY A N   1 
ATOM   2596 C CA  . GLY A  1 315 ? 11.45599  -21.51952 24.71039  1.000 24.30638 ? 314  GLY A CA  1 
ATOM   2597 C C   . GLY A  1 315 ? 10.95365  -22.91695 25.01374  1.000 27.14773 ? 314  GLY A C   1 
ATOM   2598 O O   . GLY A  1 315 ? 9.73852   -23.13767 25.01334  1.000 29.61379 ? 314  GLY A O   1 
ATOM   2599 N N   A GLU A  1 316 ? 11.84327  -23.85889 25.31571  0.575 27.31067 ? 315  GLU A N   1 
ATOM   2600 N N   B GLU A  1 316 ? 11.85057  -23.86186 25.29042  0.425 27.36681 ? 315  GLU A N   1 
ATOM   2601 C CA  A GLU A  1 316 ? 11.47019  -25.26317 25.41953  0.575 30.75941 ? 315  GLU A CA  1 
ATOM   2602 C CA  B GLU A  1 316 ? 11.41525  -25.23325 25.52968  0.425 30.59864 ? 315  GLU A CA  1 
ATOM   2603 C C   A GLU A  1 316 ? 10.77283  -25.57073 26.74035  0.575 31.40674 ? 315  GLU A C   1 
ATOM   2604 C C   B GLU A  1 316 ? 10.74721  -25.37004 26.88937  0.425 31.12651 ? 315  GLU A C   1 
ATOM   2605 O O   A GLU A  1 316 ? 10.89334  -24.84297 27.72788  0.575 27.48781 ? 315  GLU A O   1 
ATOM   2606 O O   B GLU A  1 316 ? 11.04757  -24.63740 27.83406  0.425 28.04053 ? 315  GLU A O   1 
ATOM   2607 C CB  A GLU A  1 316 ? 12.70308  -26.15974 25.28228  0.575 31.27816 ? 315  GLU A CB  1 
ATOM   2608 C CB  B GLU A  1 316 ? 12.58881  -26.21144 25.45557  0.425 30.99527 ? 315  GLU A CB  1 
ATOM   2609 C CG  A GLU A  1 316 ? 13.36561  -26.10894 23.91182  0.575 35.14954 ? 315  GLU A CG  1 
ATOM   2610 C CG  B GLU A  1 316 ? 13.56388  -25.94936 24.33424  0.425 34.15750 ? 315  GLU A CG  1 
ATOM   2611 C CD  A GLU A  1 316 ? 14.28270  -24.90928 23.74795  0.575 33.13694 ? 315  GLU A CD  1 
ATOM   2612 C CD  B GLU A  1 316 ? 14.75420  -25.14130 24.79233  0.425 38.61925 ? 315  GLU A CD  1 
ATOM   2613 O OE1 A GLU A  1 316 ? 14.55882  -24.23364 24.76238  0.575 37.73274 ? 315  GLU A OE1 1 
ATOM   2614 O OE1 B GLU A  1 316 ? 14.65385  -23.89700 24.84367  0.425 36.84676 ? 315  GLU A OE1 1 
ATOM   2615 O OE2 A GLU A  1 316 ? 14.72781  -24.63615 22.61088  0.575 40.56926 ? 315  GLU A OE2 1 
ATOM   2616 O OE2 B GLU A  1 316 ? 15.79107  -25.76131 25.11138  0.425 38.10304 ? 315  GLU A OE2 1 
ATOM   2617 N N   A ASP A  1 317 ? 10.03454  -26.67946 26.74197  0.575 30.04362 ? 316  ASP A N   1 
ATOM   2618 N N   B ASP A  1 317 ? 9.84148   -26.33973 26.98506  0.425 30.47705 ? 316  ASP A N   1 
ATOM   2619 C CA  A ASP A  1 317 ? 9.50605   -27.28974 27.94570  0.575 33.17407 ? 316  ASP A CA  1 
ATOM   2620 C CA  B ASP A  1 317 ? 9.19574   -26.67723 28.24584  0.425 34.69072 ? 316  ASP A CA  1 
ATOM   2621 C C   A ASP A  1 317 ? 10.08644  -28.68927 28.09129  0.575 36.52959 ? 316  ASP A C   1 
ATOM   2622 C C   B ASP A  1 317 ? 9.33955   -28.17778 28.45331  0.425 35.81607 ? 316  ASP A C   1 
ATOM   2623 O O   A ASP A  1 317 ? 10.05061  -29.46882 27.12870  0.575 36.17771 ? 316  ASP A O   1 
ATOM   2624 O O   B ASP A  1 317 ? 8.89531   -28.96559 27.59083  0.425 39.80173 ? 316  ASP A O   1 
ATOM   2625 C CB  A ASP A  1 317 ? 7.97124   -27.36296 27.91306  0.575 35.65552 ? 316  ASP A CB  1 
ATOM   2626 C CB  B ASP A  1 317 ? 7.73186   -26.23909 28.25161  0.425 40.58965 ? 316  ASP A CB  1 
ATOM   2627 C CG  A ASP A  1 317 ? 7.32101   -26.06669 28.34206  0.575 41.72471 ? 316  ASP A CG  1 
ATOM   2628 C CG  B ASP A  1 317 ? 7.55941   -24.81890 28.76148  0.425 39.43982 ? 316  ASP A CG  1 
ATOM   2629 O OD1 A ASP A  1 317 ? 7.73201   -25.51824 29.38994  0.575 43.59787 ? 316  ASP A OD1 1 
ATOM   2630 O OD1 B ASP A  1 317 ? 7.81806   -24.58994 29.96310  0.425 43.88010 ? 316  ASP A OD1 1 
ATOM   2631 O OD2 A ASP A  1 317 ? 6.40399   -25.59576 27.63432  0.575 47.40951 ? 316  ASP A OD2 1 
ATOM   2632 O OD2 B ASP A  1 317 ? 7.19027   -23.93224 27.95988  0.425 45.03818 ? 316  ASP A OD2 1 
ATOM   2633 N N   A PRO A  1 318 ? 10.64571  -29.04481 29.25697  0.575 34.67341 ? 317  PRO A N   1 
ATOM   2634 N N   B PRO A  1 318 ? 9.94849   -28.62890 29.56137  0.425 34.32330 ? 317  PRO A N   1 
ATOM   2635 C CA  A PRO A  1 318 ? 10.78773  -28.15129 30.41019  0.575 34.31794 ? 317  PRO A CA  1 
ATOM   2636 C CA  B PRO A  1 318 ? 10.40044  -27.80062 30.68915  0.425 32.15842 ? 317  PRO A CA  1 
ATOM   2637 C C   A PRO A  1 318 ? 11.90998  -27.14539 30.21141  0.575 30.97152 ? 317  PRO A C   1 
ATOM   2638 C C   B PRO A  1 318 ? 11.66416  -26.97433 30.42095  0.425 31.78950 ? 317  PRO A C   1 
ATOM   2639 O O   A PRO A  1 318 ? 12.69365  -27.28670 29.27072  0.575 27.20581 ? 317  PRO A O   1 
ATOM   2640 O O   B PRO A  1 318 ? 12.32435  -27.16437 29.39913  0.425 28.44658 ? 317  PRO A O   1 
ATOM   2641 C CB  A PRO A  1 318 ? 11.12305  -29.11021 31.55074  0.575 37.64290 ? 317  PRO A CB  1 
ATOM   2642 C CB  B PRO A  1 318 ? 10.67024  -28.83594 31.77854  0.425 36.45949 ? 317  PRO A CB  1 
ATOM   2643 C CG  A PRO A  1 318 ? 11.86386  -30.21492 30.87440  0.575 36.14220 ? 317  PRO A CG  1 
ATOM   2644 C CG  B PRO A  1 318 ? 11.13233  -30.03407 31.01434  0.425 37.52092 ? 317  PRO A CG  1 
ATOM   2645 C CD  A PRO A  1 318 ? 11.21368  -30.37953 29.52458  0.575 34.46717 ? 317  PRO A CD  1 
ATOM   2646 C CD  B PRO A  1 318 ? 10.32769  -30.04323 29.73717  0.425 36.64475 ? 317  PRO A CD  1 
ATOM   2647 N N   A TYR A  1 319 ? 11.96802  -26.13545 31.07540  0.575 28.62839 ? 318  TYR A N   1 
ATOM   2648 N N   B TYR A  1 319 ? 11.98113  -26.06650 31.34532  0.425 28.17282 ? 318  TYR A N   1 
ATOM   2649 C CA  A TYR A  1 319 ? 13.10625  -25.23600 31.07736  0.575 26.66037 ? 318  TYR A CA  1 
ATOM   2650 C CA  B TYR A  1 319 ? 13.15934  -25.22492 31.19804  0.425 26.77137 ? 318  TYR A CA  1 
ATOM   2651 C C   A TYR A  1 319 ? 14.39650  -26.05905 31.07347  0.575 23.22794 ? 318  TYR A C   1 
ATOM   2652 C C   B TYR A  1 319 ? 14.39765  -26.10793 31.06419  0.425 23.30762 ? 318  TYR A C   1 
ATOM   2653 O O   A TYR A  1 319 ? 14.58081  -26.92188 31.94308  0.575 27.66242 ? 318  TYR A O   1 
ATOM   2654 O O   B TYR A  1 319 ? 14.55859  -27.05749 31.84202  0.425 27.74916 ? 318  TYR A O   1 
ATOM   2655 C CB  A TYR A  1 319 ? 13.05038  -24.30123 32.28799  0.575 24.46555 ? 318  TYR A CB  1 
ATOM   2656 C CB  B TYR A  1 319 ? 13.32082  -24.28821 32.39723  0.425 25.04487 ? 318  TYR A CB  1 
ATOM   2657 C CG  A TYR A  1 319 ? 14.18916  -23.31696 32.30410  0.575 20.43702 ? 318  TYR A CG  1 
ATOM   2658 C CG  B TYR A  1 319 ? 14.27970  -23.17069 32.08718  0.425 20.57505 ? 318  TYR A CG  1 
ATOM   2659 C CD1 A TYR A  1 319 ? 14.25038  -22.26647 31.39533  0.575 16.73139 ? 318  TYR A CD1 1 
ATOM   2660 C CD1 B TYR A  1 319 ? 13.97077  -22.22927 31.11704  0.425 17.95383 ? 318  TYR A CD1 1 
ATOM   2661 C CD2 A TYR A  1 319 ? 15.22592  -23.46076 33.20594  0.575 21.26763 ? 318  TYR A CD2 1 
ATOM   2662 C CD2 B TYR A  1 319 ? 15.54233  -23.12685 32.66636  0.425 22.55441 ? 318  TYR A CD2 1 
ATOM   2663 C CE1 A TYR A  1 319 ? 15.31065  -21.38432 31.39831  0.575 19.62761 ? 318  TYR A CE1 1 
ATOM   2664 C CE1 B TYR A  1 319 ? 14.85337  -21.22877 30.79069  0.425 17.23448 ? 318  TYR A CE1 1 
ATOM   2665 C CE2 A TYR A  1 319 ? 16.28771  -22.58947 33.21702  0.575 21.87219 ? 318  TYR A CE2 1 
ATOM   2666 C CE2 B TYR A  1 319 ? 16.44302  -22.12938 32.33560  0.425 19.16538 ? 318  TYR A CE2 1 
ATOM   2667 C CZ  A TYR A  1 319 ? 16.32825  -21.55195 32.31563  0.575 18.21164 ? 318  TYR A CZ  1 
ATOM   2668 C CZ  B TYR A  1 319 ? 16.08974  -21.18447 31.39411  0.425 19.03959 ? 318  TYR A CZ  1 
ATOM   2669 O OH  A TYR A  1 319 ? 17.39663  -20.68913 32.35312  0.575 16.81958 ? 318  TYR A OH  1 
ATOM   2670 O OH  B TYR A  1 319 ? 16.95614  -20.17992 31.03783  0.425 22.02310 ? 318  TYR A OH  1 
ATOM   2671 N N   . PRO A  1 320 ? 15.29543  -25.83262 30.11440  1.000 23.71997 ? 319  PRO A N   1 
ATOM   2672 C CA  . PRO A  1 320 ? 16.33526  -26.81799 29.78005  1.000 26.88135 ? 319  PRO A CA  1 
ATOM   2673 C C   . PRO A  1 320 ? 17.55593  -26.88011 30.68275  1.000 29.15673 ? 319  PRO A C   1 
ATOM   2674 O O   . PRO A  1 320 ? 18.42448  -27.72165 30.42839  1.000 25.40061 ? 319  PRO A O   1 
ATOM   2675 C CB  . PRO A  1 320 ? 16.74873  -26.38488 28.36514  1.000 29.07028 ? 319  PRO A CB  1 
ATOM   2676 C CG  . PRO A  1 320 ? 16.51049  -24.90823 28.36538  1.000 25.43131 ? 319  PRO A CG  1 
ATOM   2677 C CD  . PRO A  1 320 ? 15.24748  -24.72435 29.14223  1.000 23.92136 ? 319  PRO A CD  1 
ATOM   2678 N N   . ASN A  1 321 ? 17.70125  -26.04329 31.70387  1.000 21.00097 ? 320  ASN A N   1 
ATOM   2679 C CA  . ASN A  1 321 ? 18.82608  -26.21276 32.61475  1.000 23.12924 ? 320  ASN A CA  1 
ATOM   2680 C C   . ASN A  1 321 ? 18.41083  -25.66661 33.96837  1.000 21.90236 ? 320  ASN A C   1 
ATOM   2681 O O   . ASN A  1 321 ? 17.24469  -25.33091 34.18208  1.000 23.29193 ? 320  ASN A O   1 
ATOM   2682 C CB  . ASN A  1 321 ? 20.09397  -25.53013 32.08412  1.000 22.51656 ? 320  ASN A CB  1 
ATOM   2683 C CG  . ASN A  1 321 ? 19.85756  -24.08083 31.71875  1.000 26.71227 ? 320  ASN A CG  1 
ATOM   2684 O OD1 . ASN A  1 321 ? 19.42745  -23.29181 32.55563  1.000 22.04088 ? 320  ASN A OD1 1 
ATOM   2685 N ND2 . ASN A  1 321 ? 20.12349  -23.72339 30.46113  1.000 22.07021 ? 320  ASN A ND2 1 
ATOM   2686 N N   . ALA A  1 322 ? 19.37045  -25.58033 34.88630  1.000 20.99103 ? 321  ALA A N   1 
ATOM   2687 C CA  . ALA A  1 322 ? 19.09738  -25.12796 36.24100  1.000 19.59618 ? 321  ALA A CA  1 
ATOM   2688 C C   . ALA A  1 322 ? 19.58635  -23.70679 36.49581  1.000 20.62297 ? 321  ALA A C   1 
ATOM   2689 O O   . ALA A  1 322 ? 19.83276  -23.34047 37.65386  1.000 20.53561 ? 321  ALA A O   1 
ATOM   2690 C CB  . ALA A  1 322 ? 19.71932  -26.09137 37.25305  1.000 23.32490 ? 321  ALA A CB  1 
ATOM   2691 N N   . ASP A  1 323 ? 19.73520  -22.89726 35.44940  1.000 18.96570 ? 322  ASP A N   1 
ATOM   2692 C CA  . ASP A  1 323 ? 20.09666  -21.49260 35.61723  1.000 16.68907 ? 322  ASP A CA  1 
ATOM   2693 C C   . ASP A  1 323 ? 18.81618  -20.70655 35.85701  1.000 17.61998 ? 322  ASP A C   1 
ATOM   2694 O O   . ASP A  1 323 ? 18.11867  -20.32643 34.91186  1.000 18.95302 ? 322  ASP A O   1 
ATOM   2695 C CB  . ASP A  1 323 ? 20.84663  -20.94991 34.40149  1.000 18.86205 ? 322  ASP A CB  1 
ATOM   2696 C CG  . ASP A  1 323 ? 21.23596  -19.47834 34.57434  1.000 21.52190 ? 322  ASP A CG  1 
ATOM   2697 O OD1 . ASP A  1 323 ? 21.37758  -19.04466 35.73575  1.000 23.66461 ? 322  ASP A OD1 1 
ATOM   2698 O OD2 . ASP A  1 323 ? 21.39729  -18.74662 33.56971  1.000 20.06637 ? 322  ASP A OD2 1 
ATOM   2699 N N   . TYR A  1 324 ? 18.50475  -20.45625 37.12588  1.000 20.53539 ? 323  TYR A N   1 
ATOM   2700 C CA  . TYR A  1 324 ? 17.31934  -19.67095 37.46470  1.000 21.54098 ? 323  TYR A CA  1 
ATOM   2701 C C   . TYR A  1 324 ? 17.79474  -18.23003 37.58998  1.000 19.16102 ? 323  TYR A C   1 
ATOM   2702 O O   . TYR A  1 324 ? 18.17312  -17.75425 38.67045  1.000 20.97659 ? 323  TYR A O   1 
ATOM   2703 C CB  . TYR A  1 324 ? 16.65981  -20.23404 38.71496  1.000 20.33783 ? 323  TYR A CB  1 
ATOM   2704 C CG  . TYR A  1 324 ? 16.45674  -21.73425 38.58429  1.000 23.13450 ? 323  TYR A CG  1 
ATOM   2705 C CD1 . TYR A  1 324 ? 15.92009  -22.28894 37.41579  1.000 23.76710 ? 323  TYR A CD1 1 
ATOM   2706 C CD2 . TYR A  1 324 ? 16.84851  -22.59507 39.59119  1.000 20.73986 ? 323  TYR A CD2 1 
ATOM   2707 C CE1 . TYR A  1 324 ? 15.75933  -23.66232 37.27847  1.000 24.90060 ? 323  TYR A CE1 1 
ATOM   2708 C CE2 . TYR A  1 324 ? 16.68218  -23.96233 39.46957  1.000 22.92899 ? 323  TYR A CE2 1 
ATOM   2709 C CZ  . TYR A  1 324 ? 16.14650  -24.49307 38.31486  1.000 23.14762 ? 323  TYR A CZ  1 
ATOM   2710 O OH  . TYR A  1 324 ? 16.00290  -25.86015 38.20185  1.000 24.85632 ? 323  TYR A OH  1 
ATOM   2711 N N   . TRP A  1 325 ? 17.80751  -17.53962 36.44379  1.000 18.52942 ? 324  TRP A N   1 
ATOM   2712 C CA  . TRP A  1 325 ? 18.46856  -16.25178 36.28408  1.000 16.58799 ? 324  TRP A CA  1 
ATOM   2713 C C   . TRP A  1 325 ? 17.57105  -15.06758 36.60691  1.000 16.72095 ? 324  TRP A C   1 
ATOM   2714 O O   . TRP A  1 325 ? 18.03649  -13.92783 36.52269  1.000 16.08762 ? 324  TRP A O   1 
ATOM   2715 C CB  . TRP A  1 325 ? 19.00857  -16.10272 34.84031  1.000 14.62442 ? 324  TRP A CB  1 
ATOM   2716 C CG  . TRP A  1 325 ? 18.03187  -16.58000 33.78497  1.000 16.84337 ? 324  TRP A CG  1 
ATOM   2717 C CD1 . TRP A  1 325 ? 18.09843  -17.74983 33.08295  1.000 18.15833 ? 324  TRP A CD1 1 
ATOM   2718 C CD2 . TRP A  1 325 ? 16.84959  -15.90046 33.32381  1.000 15.65815 ? 324  TRP A CD2 1 
ATOM   2719 N NE1 . TRP A  1 325 ? 17.03248  -17.84142 32.20876  1.000 17.74199 ? 324  TRP A NE1 1 
ATOM   2720 C CE2 . TRP A  1 325 ? 16.25465  -16.72121 32.33435  1.000 16.89448 ? 324  TRP A CE2 1 
ATOM   2721 C CE3 . TRP A  1 325 ? 16.24228  -14.67424 33.64006  1.000 18.28527 ? 324  TRP A CE3 1 
ATOM   2722 C CZ2 . TRP A  1 325 ? 15.07196  -16.36289 31.67290  1.000 18.48786 ? 324  TRP A CZ2 1 
ATOM   2723 C CZ3 . TRP A  1 325 ? 15.07071  -14.31377 32.97686  1.000 18.40755 ? 324  TRP A CZ3 1 
ATOM   2724 C CH2 . TRP A  1 325 ? 14.49993  -15.15436 32.00049  1.000 17.50010 ? 324  TRP A CH2 1 
ATOM   2725 N N   . LEU A  1 326 ? 16.30208  -15.29026 36.95759  1.000 17.39785 ? 325  LEU A N   1 
ATOM   2726 C CA  . LEU A  1 326 ? 15.41727  -14.17167 37.29262  1.000 16.15478 ? 325  LEU A CA  1 
ATOM   2727 C C   . LEU A  1 326 ? 15.71205  -13.80198 38.74123  1.000 14.60015 ? 325  LEU A C   1 
ATOM   2728 O O   . LEU A  1 326 ? 15.18556  -14.40272 39.68305  1.000 17.26078 ? 325  LEU A O   1 
ATOM   2729 C CB  . LEU A  1 326 ? 13.95077  -14.53031 37.09186  1.000 17.82599 ? 325  LEU A CB  1 
ATOM   2730 C CG  . LEU A  1 326 ? 12.97937  -13.34229 37.19129  1.000 17.57021 ? 325  LEU A CG  1 
ATOM   2731 C CD1 . LEU A  1 326 ? 13.32152  -12.26674 36.17046  1.000 15.92410 ? 325  LEU A CD1 1 
ATOM   2732 C CD2 . LEU A  1 326 ? 11.51970  -13.80493 37.02783  1.000 16.14474 ? 325  LEU A CD2 1 
ATOM   2733 N N   . VAL A  1 327 ? 16.59766  -12.81487 38.89904  1.000 16.10827 ? 326  VAL A N   1 
ATOM   2734 C CA  . VAL A  1 327 ? 17.13100  -12.45031 40.21330  1.000 16.03772 ? 326  VAL A CA  1 
ATOM   2735 C C   . VAL A  1 327 ? 15.98692  -12.19421 41.17955  1.000 14.79200 ? 326  VAL A C   1 
ATOM   2736 O O   . VAL A  1 327 ? 15.05076  -11.45557 40.86265  1.000 17.24617 ? 326  VAL A O   1 
ATOM   2737 C CB  . VAL A  1 327 ? 18.03721  -11.21131 40.07936  1.000 16.43349 ? 326  VAL A CB  1 
ATOM   2738 C CG1 . VAL A  1 327 ? 18.61116  -10.81695 41.43935  1.000 19.02571 ? 326  VAL A CG1 1 
ATOM   2739 C CG2 . VAL A  1 327 ? 19.16174  -11.46586 39.07318  1.000 22.73612 ? 326  VAL A CG2 1 
ATOM   2740 N N   . GLY A  1 328 ? 16.05057  -12.81180 42.36439  1.000 17.00137 ? 327  GLY A N   1 
ATOM   2741 C CA  . GLY A  1 328 ? 15.05572  -12.58052 43.39704  1.000 17.29500 ? 327  GLY A CA  1 
ATOM   2742 C C   . GLY A  1 328 ? 13.78696  -13.39778 43.28011  1.000 20.75481 ? 327  GLY A C   1 
ATOM   2743 O O   . GLY A  1 328 ? 12.94039  -13.33042 44.17956  1.000 18.36253 ? 327  GLY A O   1 
ATOM   2744 N N   . CYS A  1 329 ? 13.61359  -14.16850 42.20785  1.000 16.44388 ? 328  CYS A N   1 
ATOM   2745 C CA  . CYS A  1 329 ? 12.38215  -14.93272 42.01101  1.000 17.18546 ? 328  CYS A CA  1 
ATOM   2746 C C   . CYS A  1 329 ? 12.50216  -16.27409 42.72254  1.000 17.73305 ? 328  CYS A C   1 
ATOM   2747 O O   . CYS A  1 329 ? 12.92018  -17.27992 42.14555  1.000 19.83986 ? 328  CYS A O   1 
ATOM   2748 C CB  . CYS A  1 329 ? 12.10010  -15.11003 40.52123  1.000 15.76691 ? 328  CYS A CB  1 
ATOM   2749 S SG  . CYS A  1 329 ? 10.52605  -15.94351 40.27794  1.000 18.50481 ? 328  CYS A SG  1 
ATOM   2750 N N   A ASP A  1 330 ? 12.12889  -16.30115 44.00556  0.538 17.75896 ? 329  ASP A N   1 
ATOM   2751 N N   B ASP A  1 330 ? 12.13458  -16.27329 44.00735  0.462 17.77581 ? 329  ASP A N   1 
ATOM   2752 C CA  A ASP A  1 330 ? 12.23137  -17.54492 44.76155  0.538 19.89829 ? 329  ASP A CA  1 
ATOM   2753 C CA  B ASP A  1 330 ? 12.18033  -17.48716 44.81354  0.462 20.03495 ? 329  ASP A CA  1 
ATOM   2754 C C   A ASP A  1 330 ? 11.23912  -18.58314 44.25655  0.538 18.23705 ? 329  ASP A C   1 
ATOM   2755 C C   B ASP A  1 330 ? 11.24613  -18.55226 44.26049  0.462 18.23971 ? 329  ASP A C   1 
ATOM   2756 O O   A ASP A  1 330 ? 11.55095  -19.78061 44.22060  0.538 19.02530 ? 329  ASP A O   1 
ATOM   2757 O O   B ASP A  1 330 ? 11.60470  -19.73496 44.19483  0.462 19.05135 ? 329  ASP A O   1 
ATOM   2758 C CB  A ASP A  1 330 ? 12.01428  -17.27644 46.25262  0.538 22.87455 ? 329  ASP A CB  1 
ATOM   2759 C CB  B ASP A  1 330 ? 11.80459  -17.14235 46.25651  0.462 21.98067 ? 329  ASP A CB  1 
ATOM   2760 C CG  A ASP A  1 330 ? 13.18049  -16.53895 46.88211  0.538 29.10820 ? 329  ASP A CG  1 
ATOM   2761 C CG  B ASP A  1 330 ? 12.54940  -15.92678 46.76906  0.462 29.42919 ? 329  ASP A CG  1 
ATOM   2762 O OD1 A ASP A  1 330 ? 14.33566  -16.84764 46.52160  0.538 26.76035 ? 329  ASP A OD1 1 
ATOM   2763 O OD1 B ASP A  1 330 ? 13.79090  -15.89321 46.62338  0.462 26.62119 ? 329  ASP A OD1 1 
ATOM   2764 O OD2 A ASP A  1 330 ? 12.93811  -15.65941 47.73492  0.538 24.73330 ? 329  ASP A OD2 1 
ATOM   2765 O OD2 B ASP A  1 330 ? 11.89309  -14.99746 47.29003  0.462 31.74539 ? 329  ASP A OD2 1 
ATOM   2766 N N   . GLU A  1 331 ? 10.03656  -18.14898 43.86610  1.000 17.90070 ? 330  GLU A N   1 
ATOM   2767 C CA  . GLU A  1 331 ? 9.07419   -19.08913 43.29987  1.000 17.44077 ? 330  GLU A CA  1 
ATOM   2768 C C   . GLU A  1 331 ? 9.60475   -19.73525 42.02346  1.000 17.28362 ? 330  GLU A C   1 
ATOM   2769 O O   . GLU A  1 331 ? 9.29093   -20.89913 41.74733  1.000 17.85620 ? 330  GLU A O   1 
ATOM   2770 C CB  . GLU A  1 331 ? 7.74486   -18.37592 43.02514  1.000 18.25016 ? 330  GLU A CB  1 
ATOM   2771 C CG  . GLU A  1 331 ? 6.92187   -18.08097 44.29278  1.000 23.81270 ? 330  GLU A CG  1 
ATOM   2772 C CD  . GLU A  1 331 ? 5.65989   -17.25810 44.02039  1.000 23.69537 ? 330  GLU A CD  1 
ATOM   2773 O OE1 . GLU A  1 331 ? 5.37794   -16.95080 42.84419  1.000 19.17603 ? 330  GLU A OE1 1 
ATOM   2774 O OE2 . GLU A  1 331 ? 4.95096   -16.91755 44.99831  1.000 22.69961 ? 330  GLU A OE2 1 
ATOM   2775 N N   . CYS A  1 332 ? 10.41872  -19.00644 41.24956  1.000 17.24206 ? 331  CYS A N   1 
ATOM   2776 C CA  . CYS A  1 332 ? 11.01272  -19.57447 40.03540  1.000 18.78072 ? 331  CYS A CA  1 
ATOM   2777 C C   . CYS A  1 332 ? 11.93414  -20.74022 40.35024  1.000 22.17083 ? 331  CYS A C   1 
ATOM   2778 O O   . CYS A  1 332 ? 12.02805  -21.69567 39.56643  1.000 20.55867 ? 331  CYS A O   1 
ATOM   2779 C CB  . CYS A  1 332 ? 11.79512  -18.50980 39.26646  1.000 20.71506 ? 331  CYS A CB  1 
ATOM   2780 S SG  . CYS A  1 332 ? 10.80697  -17.17614 38.65138  1.000 19.60683 ? 331  CYS A SG  1 
ATOM   2781 N N   . VAL A  1 333 ? 12.65465  -20.66495 41.47042  1.000 20.48199 ? 332  VAL A N   1 
ATOM   2782 C CA  . VAL A  1 333 ? 13.49394  -21.78638 41.87243  1.000 18.88201 ? 332  VAL A CA  1 
ATOM   2783 C C   . VAL A  1 333 ? 12.62380  -22.97957 42.23609  1.000 21.04153 ? 332  VAL A C   1 
ATOM   2784 O O   . VAL A  1 333 ? 12.86532  -24.10799 41.79216  1.000 21.95507 ? 332  VAL A O   1 
ATOM   2785 C CB  . VAL A  1 333 ? 14.41069  -21.37836 43.03887  1.000 22.34668 ? 332  VAL A CB  1 
ATOM   2786 C CG1 . VAL A  1 333 ? 15.20373  -22.58976 43.52736  1.000 25.60384 ? 332  VAL A CG1 1 
ATOM   2787 C CG2 . VAL A  1 333 ? 15.33432  -20.24159 42.60546  1.000 21.68828 ? 332  VAL A CG2 1 
ATOM   2788 N N   . ARG A  1 334 ? 11.58931  -22.74151 43.04791  1.000 18.52683 ? 333  ARG A N   1 
ATOM   2789 C CA  . ARG A  1 334 ? 10.63970  -23.79500 43.39262  1.000 21.09803 ? 333  ARG A CA  1 
ATOM   2790 C C   . ARG A  1 334 ? 10.07200  -24.46372 42.14820  1.000 23.43139 ? 333  ARG A C   1 
ATOM   2791 O O   . ARG A  1 334 ? 9.99331   -25.69815 42.06916  1.000 22.26267 ? 333  ARG A O   1 
ATOM   2792 C CB  . ARG A  1 334 ? 9.51301   -23.19395 44.24253  1.000 20.44323 ? 333  ARG A CB  1 
ATOM   2793 C CG  . ARG A  1 334 ? 8.35672   -24.14040 44.57554  1.000 27.38624 ? 333  ARG A CG  1 
ATOM   2794 C CD  . ARG A  1 334 ? 7.12718   -23.36117 45.07973  1.000 23.81172 ? 333  ARG A CD  1 
ATOM   2795 N NE  . ARG A  1 334 ? 6.42324   -22.68681 43.98604  1.000 24.17513 ? 333  ARG A NE  1 
ATOM   2796 C CZ  . ARG A  1 334 ? 5.50681   -21.73977 44.15264  1.000 23.17294 ? 333  ARG A CZ  1 
ATOM   2797 N NH1 . ARG A  1 334 ? 5.15355   -21.32436 45.36223  1.000 22.65139 ? 333  ARG A NH1 1 
ATOM   2798 N NH2 . ARG A  1 334 ? 4.92605   -21.19812 43.07911  1.000 24.87228 ? 333  ARG A NH2 1 
ATOM   2799 N N   . ASP A  1 335 ? 9.67680   -23.66272 41.16299  1.000 19.30560 ? 334  ASP A N   1 
ATOM   2800 C CA  . ASP A  1 335 ? 9.00885   -24.16212 39.97172  1.000 17.74489 ? 334  ASP A CA  1 
ATOM   2801 C C   . ASP A  1 335 ? 9.98635   -24.48253 38.84876  1.000 21.23746 ? 334  ASP A C   1 
ATOM   2802 O O   . ASP A  1 335 ? 9.54977   -24.85277 37.75212  1.000 23.28033 ? 334  ASP A O   1 
ATOM   2803 C CB  . ASP A  1 335 ? 7.96449   -23.13695 39.50264  1.000 20.05003 ? 334  ASP A CB  1 
ATOM   2804 C CG  . ASP A  1 335 ? 6.86143   -22.92422 40.53000  1.000 19.88126 ? 334  ASP A CG  1 
ATOM   2805 O OD1 . ASP A  1 335 ? 6.65612   -23.81513 41.37400  1.000 22.64756 ? 334  ASP A OD1 1 
ATOM   2806 O OD2 . ASP A  1 335 ? 6.20087   -21.86797 40.50508  1.000 22.98912 ? 334  ASP A OD2 1 
ATOM   2807 N N   . LYS A  1 336 ? 11.28895  -24.31522 39.09204  1.000 19.75197 ? 335  LYS A N   1 
ATOM   2808 C CA  . LYS A  1 336 ? 12.34500  -24.70346 38.14674  1.000 20.58521 ? 335  LYS A CA  1 
ATOM   2809 C C   . LYS A  1 336 ? 12.17672  -24.00630 36.79524  1.000 24.15661 ? 335  LYS A C   1 
ATOM   2810 O O   . LYS A  1 336 ? 12.35394  -24.61156 35.73294  1.000 22.11797 ? 335  LYS A O   1 
ATOM   2811 C CB  . LYS A  1 336 ? 12.35967  -26.22291 37.97639  1.000 20.51386 ? 335  LYS A CB  1 
ATOM   2812 C CG  . LYS A  1 336 ? 13.00886  -26.94988 39.17940  1.000 28.53457 ? 335  LYS A CG  1 
ATOM   2813 C CD  . LYS A  1 336 ? 12.98948  -28.46761 38.99094  1.000 32.02046 ? 335  LYS A CD  1 
ATOM   2814 C CE  . LYS A  1 336 ? 13.39261  -29.18746 40.27256  1.000 38.62779 ? 335  LYS A CE  1 
ATOM   2815 N NZ  . LYS A  1 336 ? 14.36712  -28.38710 41.05838  1.000 55.59206 ? 335  LYS A NZ  1 
ATOM   2816 N N   . ASP A  1 337 ? 11.83007  -22.72098 36.82422  1.000 19.35989 ? 336  ASP A N   1 
ATOM   2817 C CA  . ASP A  1 337 ? 11.57001  -21.99972 35.58137  1.000 18.06479 ? 336  ASP A CA  1 
ATOM   2818 C C   . ASP A  1 337 ? 11.66322  -20.50066 35.83674  1.000 18.84917 ? 336  ASP A C   1 
ATOM   2819 O O   . ASP A  1 337 ? 10.83044  -19.94547 36.56285  1.000 18.69509 ? 336  ASP A O   1 
ATOM   2820 C CB  . ASP A  1 337 ? 10.18657  -22.35381 35.02340  1.000 18.79109 ? 336  ASP A CB  1 
ATOM   2821 C CG  . ASP A  1 337 ? 10.01085  -21.93349 33.56732  1.000 18.61277 ? 336  ASP A CG  1 
ATOM   2822 O OD1 . ASP A  1 337 ? 10.64296  -20.94500 33.14304  1.000 19.99378 ? 336  ASP A OD1 1 
ATOM   2823 O OD2 . ASP A  1 337 ? 9.20661   -22.57613 32.84269  1.000 21.89489 ? 336  ASP A OD2 1 
ATOM   2824 N N   . PRO A  1 338 ? 12.65635  -19.81263 35.27576  1.000 18.12064 ? 337  PRO A N   1 
ATOM   2825 C CA  . PRO A  1 338 ? 12.76925  -18.36473 35.47693  1.000 15.19961 ? 337  PRO A CA  1 
ATOM   2826 C C   . PRO A  1 338 ? 11.92382  -17.52231 34.53475  1.000 16.26420 ? 337  PRO A C   1 
ATOM   2827 O O   . PRO A  1 338 ? 12.05140  -16.29647 34.55897  1.000 16.27653 ? 337  PRO A O   1 
ATOM   2828 C CB  . PRO A  1 338 ? 14.26244  -18.11089 35.22523  1.000 18.24504 ? 337  PRO A CB  1 
ATOM   2829 C CG  . PRO A  1 338 ? 14.60257  -19.14295 34.11758  1.000 16.94363 ? 337  PRO A CG  1 
ATOM   2830 C CD  . PRO A  1 338 ? 13.74622  -20.35455 34.43130  1.000 17.25821 ? 337  PRO A CD  1 
ATOM   2831 N N   . ARG A  1 339 ? 11.07451  -18.11355 33.68877  1.000 15.76826 ? 338  ARG A N   1 
ATOM   2832 C CA  . ARG A  1 339 ? 10.41956  -17.33745 32.64256  1.000 15.35436 ? 338  ARG A CA  1 
ATOM   2833 C C   . ARG A  1 339 ? 9.04708   -16.80572 33.03389  1.000 15.44507 ? 338  ARG A C   1 
ATOM   2834 O O   . ARG A  1 339 ? 8.48584   -15.98996 32.29247  1.000 17.54675 ? 338  ARG A O   1 
ATOM   2835 C CB  . ARG A  1 339 ? 10.28142  -18.19171 31.37432  1.000 15.65196 ? 338  ARG A CB  1 
ATOM   2836 C CG  . ARG A  1 339 ? 11.62608  -18.67854 30.86665  1.000 17.11185 ? 338  ARG A CG  1 
ATOM   2837 C CD  . ARG A  1 339 ? 11.43800  -19.72151 29.74846  1.000 14.90712 ? 338  ARG A CD  1 
ATOM   2838 N NE  . ARG A  1 339 ? 10.87451  -20.95389 30.28501  1.000 17.28269 ? 338  ARG A NE  1 
ATOM   2839 C CZ  . ARG A  1 339 ? 10.75092  -22.07479 29.58737  1.000 19.54052 ? 338  ARG A CZ  1 
ATOM   2840 N NH1 . ARG A  1 339 ? 11.12651  -22.13635 28.31973  1.000 20.81467 ? 338  ARG A NH1 1 
ATOM   2841 N NH2 . ARG A  1 339 ? 10.25408  -23.15996 30.18284  1.000 20.68686 ? 338  ARG A NH2 1 
ATOM   2842 N N   . ILE A  1 340 ? 8.49649   -17.25519 34.16161  1.000 16.42672 ? 339  ILE A N   1 
ATOM   2843 C CA  . ILE A  1 340 ? 7.18195   -16.83193 34.63791  1.000 14.29095 ? 339  ILE A CA  1 
ATOM   2844 C C   . ILE A  1 340 ? 7.32942   -16.43556 36.09921  1.000 15.84841 ? 339  ILE A C   1 
ATOM   2845 O O   . ILE A  1 340 ? 7.89362   -17.19795 36.88396  1.000 18.47380 ? 339  ILE A O   1 
ATOM   2846 C CB  . ILE A  1 340 ? 6.14294   -17.95984 34.51979  1.000 20.78495 ? 339  ILE A CB  1 
ATOM   2847 C CG1 . ILE A  1 340 ? 5.94796   -18.37022 33.05213  1.000 22.82489 ? 339  ILE A CG1 1 
ATOM   2848 C CG2 . ILE A  1 340 ? 4.83214   -17.56428 35.20563  1.000 22.52839 ? 339  ILE A CG2 1 
ATOM   2849 C CD1 . ILE A  1 340 ? 5.06803   -17.44627 32.27516  1.000 29.55325 ? 339  ILE A CD1 1 
ATOM   2850 N N   . ALA A  1 341 ? 6.80239   -15.26665 36.46794  1.000 16.03168 ? 340  ALA A N   1 
ATOM   2851 C CA  . ALA A  1 341 ? 6.81209   -14.85275 37.87132  1.000 16.87050 ? 340  ALA A CA  1 
ATOM   2852 C C   . ALA A  1 341 ? 5.45108   -14.28582 38.24009  1.000 16.92095 ? 340  ALA A C   1 
ATOM   2853 O O   . ALA A  1 341 ? 4.97030   -13.35310 37.59039  1.000 17.68728 ? 340  ALA A O   1 
ATOM   2854 C CB  . ALA A  1 341 ? 7.89553   -13.79922 38.13984  1.000 16.85723 ? 340  ALA A CB  1 
ATOM   2855 N N   . SER A  1 342 ? 4.86215   -14.82708 39.29951  1.000 15.21703 ? 341  SER A N   1 
ATOM   2856 C CA  . SER A  1 342 ? 3.59741   -14.31321 39.80294  1.000 17.73385 ? 341  SER A CA  1 
ATOM   2857 C C   . SER A  1 342 ? 3.71581   -12.84202 40.16385  1.000 17.80590 ? 341  SER A C   1 
ATOM   2858 O O   . SER A  1 342 ? 4.79129   -12.35063 40.52139  1.000 16.47184 ? 341  SER A O   1 
ATOM   2859 C CB  . SER A  1 342 ? 3.17428   -15.09065 41.04452  1.000 16.65400 ? 341  SER A CB  1 
ATOM   2860 O OG  . SER A  1 342 ? 4.09500   -14.85266 42.11004  1.000 17.48468 ? 341  SER A OG  1 
ATOM   2861 N N   . TYR A  1 343 ? 2.58684   -12.13384 40.08606  1.000 14.31615 ? 342  TYR A N   1 
ATOM   2862 C CA  . TYR A  1 343 ? 2.56841   -10.77467 40.60568  1.000 17.27033 ? 342  TYR A CA  1 
ATOM   2863 C C   . TYR A  1 343 ? 3.04704   -10.76004 42.05634  1.000 16.39563 ? 342  TYR A C   1 
ATOM   2864 O O   . TYR A  1 343 ? 3.81069   -9.87040  42.45701  1.000 17.46898 ? 342  TYR A O   1 
ATOM   2865 C CB  . TYR A  1 343 ? 1.16182   -10.16773 40.48549  1.000 15.91327 ? 342  TYR A CB  1 
ATOM   2866 C CG  . TYR A  1 343 ? 1.13476   -8.78456  41.08878  1.000 15.43218 ? 342  TYR A CG  1 
ATOM   2867 C CD1 . TYR A  1 343 ? 1.68582   -7.70728  40.41247  1.000 16.14572 ? 342  TYR A CD1 1 
ATOM   2868 C CD2 . TYR A  1 343 ? 0.61077   -8.57050  42.35387  1.000 17.13032 ? 342  TYR A CD2 1 
ATOM   2869 C CE1 . TYR A  1 343 ? 1.69974   -6.43994  40.97189  1.000 19.69817 ? 342  TYR A CE1 1 
ATOM   2870 C CE2 . TYR A  1 343 ? 0.61539   -7.31509  42.91738  1.000 17.87530 ? 342  TYR A CE2 1 
ATOM   2871 C CZ  . TYR A  1 343 ? 1.16666   -6.25326  42.22515  1.000 20.63905 ? 342  TYR A CZ  1 
ATOM   2872 O OH  . TYR A  1 343 ? 1.18583   -5.00026  42.80694  1.000 20.80170 ? 342  TYR A OH  1 
ATOM   2873 N N   A ARG A  1 344 ? 2.60803   -11.74690 42.84559  0.581 15.44759 ? 343  ARG A N   1 
ATOM   2874 N N   B ARG A  1 344 ? 2.63206   -11.75380 42.84655  0.419 15.46899 ? 343  ARG A N   1 
ATOM   2875 C CA  A ARG A  1 344 ? 3.04597   -11.89698 44.23675  0.581 16.08886 ? 343  ARG A CA  1 
ATOM   2876 C CA  B ARG A  1 344 ? 3.05932   -11.82891 44.24445  0.419 16.13280 ? 343  ARG A CA  1 
ATOM   2877 C C   A ARG A  1 344 ? 4.56344   -11.83070 44.35117  0.581 18.56663 ? 343  ARG A C   1 
ATOM   2878 C C   B ARG A  1 344 ? 4.57852   -11.82525 44.36161  0.419 18.53661 ? 343  ARG A C   1 
ATOM   2879 O O   A ARG A  1 344 ? 5.11009   -11.09804 45.18163  0.581 19.54640 ? 343  ARG A O   1 
ATOM   2880 O O   B ARG A  1 344 ? 5.14262   -11.13421 45.21683  0.419 19.53273 ? 343  ARG A O   1 
ATOM   2881 C CB  A ARG A  1 344 ? 2.52441   -13.22485 44.79199  0.581 16.85379 ? 343  ARG A CB  1 
ATOM   2882 C CB  B ARG A  1 344 ? 2.48327   -13.07934 44.90314  0.419 17.14048 ? 343  ARG A CB  1 
ATOM   2883 C CG  A ARG A  1 344 ? 2.99592   -13.56570 46.20346  0.581 17.42683 ? 343  ARG A CG  1 
ATOM   2884 C CG  B ARG A  1 344 ? 2.85508   -13.21458 46.37377  0.419 16.84743 ? 343  ARG A CG  1 
ATOM   2885 C CD  A ARG A  1 344 ? 2.45972   -14.92155 46.65279  0.581 18.11761 ? 343  ARG A CD  1 
ATOM   2886 C CD  B ARG A  1 344 ? 2.34201   -14.51416 46.96179  0.419 19.44829 ? 343  ARG A CD  1 
ATOM   2887 N NE  A ARG A  1 344 ? 1.01547   -15.02897 46.46142  0.581 19.93424 ? 343  ARG A NE  1 
ATOM   2888 N NE  B ARG A  1 344 ? 2.64681   -14.62713 48.38406  0.419 24.00769 ? 343  ARG A NE  1 
ATOM   2889 C CZ  A ARG A  1 344 ? 0.14272   -15.32503 47.41523  0.581 21.87626 ? 343  ARG A CZ  1 
ATOM   2890 C CZ  B ARG A  1 344 ? 1.91382   -15.30069 49.25992  0.419 27.04000 ? 343  ARG A CZ  1 
ATOM   2891 N NH1 A ARG A  1 344 ? 0.52487   -15.54160 48.66593  0.581 23.44762 ? 343  ARG A NH1 1 
ATOM   2892 N NH1 B ARG A  1 344 ? 0.79904   -15.92022 48.90177  0.419 22.81067 ? 343  ARG A NH1 1 
ATOM   2893 N NH2 A ARG A  1 344 ? -1.14853  -15.39988 47.11058  0.581 20.43236 ? 343  ARG A NH2 1 
ATOM   2894 N NH2 B ARG A  1 344 ? 2.31248   -15.36192 50.52622  0.419 15.57456 ? 343  ARG A NH2 1 
ATOM   2895 N N   . GLN A  1 345 ? 5.25893   -12.58761 43.50423  1.000 15.17940 ? 344  GLN A N   1 
ATOM   2896 C CA  . GLN A  1 345 ? 6.71149   -12.60359 43.53053  1.000 18.12074 ? 344  GLN A CA  1 
ATOM   2897 C C   . GLN A  1 345 ? 7.29679   -11.31786 42.95049  1.000 17.17857 ? 344  GLN A C   1 
ATOM   2898 O O   . GLN A  1 345 ? 8.31256   -10.81894 43.43971  1.000 17.68819 ? 344  GLN A O   1 
ATOM   2899 C CB  . GLN A  1 345 ? 7.20035   -13.83405 42.76053  1.000 16.97597 ? 344  GLN A CB  1 
ATOM   2900 C CG  . GLN A  1 345 ? 8.70766   -14.02767 42.78943  1.000 21.64128 ? 344  GLN A CG  1 
ATOM   2901 C CD  . GLN A  1 345 ? 9.16297   -14.43476 44.15835  1.000 21.30832 ? 344  GLN A CD  1 
ATOM   2902 O OE1 . GLN A  1 345 ? 9.02406   -15.59882 44.54148  1.000 22.13778 ? 344  GLN A OE1 1 
ATOM   2903 N NE2 . GLN A  1 345 ? 9.66234   -13.47251 44.93831  1.000 22.41284 ? 344  GLN A NE2 1 
ATOM   2904 N N   . LEU A  1 346 ? 6.68466   -10.77277 41.89144  1.000 15.44245 ? 345  LEU A N   1 
ATOM   2905 C CA  . LEU A  1 346 ? 7.20520   -9.55298  41.27995  1.000 15.75388 ? 345  LEU A CA  1 
ATOM   2906 C C   . LEU A  1 346 ? 7.23802   -8.39065  42.26887  1.000 16.96927 ? 345  LEU A C   1 
ATOM   2907 O O   . LEU A  1 346 ? 8.16714   -7.57322  42.24873  1.000 18.22477 ? 345  LEU A O   1 
ATOM   2908 C CB  . LEU A  1 346 ? 6.36669   -9.18453  40.05668  1.000 17.01428 ? 345  LEU A CB  1 
ATOM   2909 C CG  . LEU A  1 346 ? 6.57492   -10.11224 38.85992  1.000 16.87548 ? 345  LEU A CG  1 
ATOM   2910 C CD1 . LEU A  1 346 ? 5.53981   -9.81787  37.76342  1.000 15.57726 ? 345  LEU A CD1 1 
ATOM   2911 C CD2 . LEU A  1 346 ? 7.99039   -9.96994  38.31482  1.000 15.95370 ? 345  LEU A CD2 1 
ATOM   2912 N N   . GLU A  1 347 ? 6.22450   -8.28331  43.12687  1.000 18.17524 ? 346  GLU A N   1 
ATOM   2913 C CA  . GLU A  1 347 ? 6.24551   -7.24265  44.15032  1.000 18.36804 ? 346  GLU A CA  1 
ATOM   2914 C C   . GLU A  1 347 ? 7.47517   -7.38101  45.03215  1.000 16.80576 ? 346  GLU A C   1 
ATOM   2915 O O   . GLU A  1 347 ? 8.15017   -6.39420  45.34159  1.000 19.08337 ? 346  GLU A O   1 
ATOM   2916 C CB  . GLU A  1 347 ? 4.99357   -7.32632  45.01937  1.000 21.11898 ? 346  GLU A CB  1 
ATOM   2917 C CG  . GLU A  1 347 ? 3.74181   -6.80052  44.37772  1.000 24.43235 ? 346  GLU A CG  1 
ATOM   2918 C CD  . GLU A  1 347 ? 2.66332   -6.52369  45.41898  1.000 26.64998 ? 346  GLU A CD  1 
ATOM   2919 O OE1 . GLU A  1 347 ? 2.57833   -7.28822  46.40347  1.000 20.28086 ? 346  GLU A OE1 1 
ATOM   2920 O OE2 . GLU A  1 347 ? 1.91593   -5.53539  45.25972  1.000 25.42065 ? 346  GLU A OE2 1 
ATOM   2921 N N   . GLN A  1 348 ? 7.75688   -8.60285  45.47236  1.000 15.39548 ? 347  GLN A N   1 
ATOM   2922 C CA  . GLN A  1 348 ? 8.92015   -8.82791  46.32239  1.000 16.60713 ? 347  GLN A CA  1 
ATOM   2923 C C   . GLN A  1 348 ? 10.21000  -8.55272  45.56827  1.000 18.64953 ? 347  GLN A C   1 
ATOM   2924 O O   . GLN A  1 348 ? 11.17829  -8.04024  46.14497  1.000 18.83994 ? 347  GLN A O   1 
ATOM   2925 C CB  . GLN A  1 348 ? 8.90448   -10.25829 46.85423  1.000 18.27476 ? 347  GLN A CB  1 
ATOM   2926 C CG  . GLN A  1 348 ? 7.74300   -10.53018 47.82000  1.000 17.59272 ? 347  GLN A CG  1 
ATOM   2927 C CD  . GLN A  1 348 ? 7.52222   -11.99345 48.09431  1.000 23.37641 ? 347  GLN A CD  1 
ATOM   2928 O OE1 . GLN A  1 348 ? 8.24293   -12.61369 48.88805  1.000 21.13565 ? 347  GLN A OE1 1 
ATOM   2929 N NE2 . GLN A  1 348 ? 6.51452   -12.56932 47.43825  1.000 20.55881 ? 347  GLN A NE2 1 
ATOM   2930 N N   A MET A  1 349 ? 10.25419  -8.89891  44.28004  0.601 16.11076 ? 348  MET A N   1 
ATOM   2931 N N   B MET A  1 349 ? 10.24038  -8.86845  44.27468  0.399 16.17734 ? 348  MET A N   1 
ATOM   2932 C CA  A MET A  1 349 ? 11.46111  -8.64286  43.50437  0.601 15.70150 ? 348  MET A CA  1 
ATOM   2933 C CA  B MET A  1 349 ? 11.43897  -8.61713  43.48693  0.399 15.70280 ? 348  MET A CA  1 
ATOM   2934 C C   A MET A  1 349 ? 11.73159  -7.15179  43.39630  0.601 15.65857 ? 348  MET A C   1 
ATOM   2935 C C   B MET A  1 349 ? 11.69048  -7.12131  43.34999  0.399 15.71865 ? 348  MET A C   1 
ATOM   2936 O O   A MET A  1 349 ? 12.88646  -6.71561  43.44703  0.601 19.27908 ? 348  MET A O   1 
ATOM   2937 O O   B MET A  1 349 ? 12.84154  -6.67125  43.36819  0.399 19.22886 ? 348  MET A O   1 
ATOM   2938 C CB  A MET A  1 349 ? 11.33961  -9.25494  42.10311  0.601 15.84903 ? 348  MET A CB  1 
ATOM   2939 C CB  B MET A  1 349 ? 11.29287  -9.27519  42.11085  0.399 15.81446 ? 348  MET A CB  1 
ATOM   2940 C CG  A MET A  1 349 ? 11.53396  -10.75637 42.06506  0.601 15.80004 ? 348  MET A CG  1 
ATOM   2941 C CG  B MET A  1 349 ? 11.41210  -10.79111 42.17161  0.399 15.41922 ? 348  MET A CG  1 
ATOM   2942 S SD  A MET A  1 349 ? 10.62368  -11.48792 40.67202  0.601 18.11830 ? 348  MET A SD  1 
ATOM   2943 S SD  B MET A  1 349 ? 10.80824  -11.61541 40.67208  0.399 18.11623 ? 348  MET A SD  1 
ATOM   2944 C CE  A MET A  1 349 ? 11.60761  -10.84185 39.32520  0.601 16.38861 ? 348  MET A CE  1 
ATOM   2945 C CE  B MET A  1 349 ? 11.35591  -10.45545 39.42640  0.399 17.71331 ? 348  MET A CE  1 
ATOM   2946 N N   A LEU A  1 350 ? 10.67767  -6.35645  43.22380  0.601 16.19262 ? 349  LEU A N   1 
ATOM   2947 N N   B LEU A  1 350 ? 10.62077  -6.33698  43.21152  0.399 16.25856 ? 349  LEU A N   1 
ATOM   2948 C CA  A LEU A  1 350 ? 10.83941  -4.91158  43.12644  0.601 18.25419 ? 349  LEU A CA  1 
ATOM   2949 C CA  B LEU A  1 350 ? 10.75366  -4.88797  43.12032  0.399 18.32360 ? 349  LEU A CA  1 
ATOM   2950 C C   A LEU A  1 350 ? 11.21713  -4.31185  44.47572  0.601 19.75008 ? 349  LEU A C   1 
ATOM   2951 C C   B LEU A  1 350 ? 11.16598  -4.29042  44.46102  0.399 19.80505 ? 349  LEU A C   1 
ATOM   2952 O O   A LEU A  1 350 ? 11.99117  -3.34921  44.54296  0.601 21.46135 ? 349  LEU A O   1 
ATOM   2953 O O   B LEU A  1 350 ? 11.92328  -3.31389  44.50988  0.399 21.46982 ? 349  LEU A O   1 
ATOM   2954 C CB  A LEU A  1 350 ? 9.54412   -4.28603  42.61156  0.601 21.40081 ? 349  LEU A CB  1 
ATOM   2955 C CB  B LEU A  1 350 ? 9.42861   -4.28599  42.65381  0.399 21.41812 ? 349  LEU A CB  1 
ATOM   2956 C CG  A LEU A  1 350 ? 9.56424   -2.86052  42.07384  0.601 25.63089 ? 349  LEU A CG  1 
ATOM   2957 C CG  B LEU A  1 350 ? 9.37016   -3.38510  41.42169  0.399 27.21305 ? 349  LEU A CG  1 
ATOM   2958 C CD1 A LEU A  1 350 ? 10.48983  -2.75583  40.87205  0.601 23.03937 ? 349  LEU A CD1 1 
ATOM   2959 C CD1 B LEU A  1 350 ? 8.23979   -2.37943  41.58908  0.399 27.06715 ? 349  LEU A CD1 1 
ATOM   2960 C CD2 A LEU A  1 350 ? 8.14592   -2.44867  41.70266  0.601 27.02122 ? 349  LEU A CD2 1 
ATOM   2961 C CD2 B LEU A  1 350 ? 10.69317  -2.67090  41.20435  0.399 22.33855 ? 349  LEU A CD2 1 
ATOM   2962 N N   . GLN A  1 351 ? 10.67624  -4.86811  45.55547  1.000 19.31155 ? 350  GLN A N   1 
ATOM   2963 C CA  . GLN A  1 351 ? 10.94144  -4.32993  46.88428  1.000 16.83167 ? 350  GLN A CA  1 
ATOM   2964 C C   . GLN A  1 351 ? 12.33948  -4.66331  47.38945  1.000 20.21278 ? 350  GLN A C   1 
ATOM   2965 O O   . GLN A  1 351 ? 12.91869  -3.87711  48.14927  1.000 19.28074 ? 350  GLN A O   1 
ATOM   2966 C CB  . GLN A  1 351 ? 9.89833   -4.86045  47.85732  1.000 16.82884 ? 350  GLN A CB  1 
ATOM   2967 C CG  . GLN A  1 351 ? 8.58389   -4.13486  47.72683  1.000 22.24316 ? 350  GLN A CG  1 
ATOM   2968 C CD  . GLN A  1 351 ? 7.44195   -4.86033  48.39936  1.000 25.71146 ? 350  GLN A CD  1 
ATOM   2969 O OE1 . GLN A  1 351 ? 6.40894   -5.11668  47.78154  1.000 26.80775 ? 350  GLN A OE1 1 
ATOM   2970 N NE2 . GLN A  1 351 ? 7.60507   -5.16421  49.68087  1.000 26.37592 ? 350  GLN A NE2 1 
ATOM   2971 N N   . GLY A  1 352 ? 12.88049  -5.82084  47.01987  1.000 18.04800 ? 351  GLY A N   1 
ATOM   2972 C CA  . GLY A  1 352 ? 14.19533  -6.22707  47.47024  1.000 17.97281 ? 351  GLY A CA  1 
ATOM   2973 C C   . GLY A  1 352 ? 15.32284  -5.55643  46.69547  1.000 19.00816 ? 351  GLY A C   1 
ATOM   2974 O O   . GLY A  1 352 ? 15.11940  -4.81050  45.73892  1.000 20.91753 ? 351  GLY A O   1 
ATOM   2975 N N   . ASN A  1 353 ? 16.54908  -5.84557  47.13609  1.000 19.70153 ? 352  ASN A N   1 
ATOM   2976 C CA  . ASN A  1 353 ? 17.76553  -5.29960  46.53010  1.000 21.71867 ? 352  ASN A CA  1 
ATOM   2977 C C   . ASN A  1 353 ? 18.17532  -6.14953  45.32859  1.000 26.58327 ? 352  ASN A C   1 
ATOM   2978 O O   . ASN A  1 353 ? 19.23225  -6.77799  45.33283  1.000 24.75838 ? 352  ASN A O   1 
ATOM   2979 C CB  . ASN A  1 353 ? 18.89928  -5.27330  47.55456  1.000 22.14225 ? 352  ASN A CB  1 
ATOM   2980 C CG  . ASN A  1 353 ? 18.70333  -4.22983  48.63826  1.000 36.22731 ? 352  ASN A CG  1 
ATOM   2981 O OD1 . ASN A  1 353 ? 17.91781  -3.30185  48.48630  1.000 34.45325 ? 352  ASN A OD1 1 
ATOM   2982 N ND2 . ASN A  1 353 ? 19.39516  -4.41002  49.76779  1.000 31.00680 ? 352  ASN A ND2 1 
ATOM   2983 N N   . TYR A  1 354 ? 17.31454  -6.20397  44.30841  1.000 21.12087 ? 353  TYR A N   1 
ATOM   2984 C CA  . TYR A  1 354 ? 17.55305  -7.13255  43.21060  1.000 19.29474 ? 353  TYR A CA  1 
ATOM   2985 C C   . TYR A  1 354 ? 17.84174  -6.46006  41.87943  1.000 20.93069 ? 353  TYR A C   1 
ATOM   2986 O O   . TYR A  1 354 ? 18.07853  -7.16884  40.90057  1.000 26.04033 ? 353  TYR A O   1 
ATOM   2987 C CB  . TYR A  1 354 ? 16.36820  -8.09439  43.05752  1.000 17.76972 ? 353  TYR A CB  1 
ATOM   2988 C CG  . TYR A  1 354 ? 16.15850  -8.95596  44.27787  1.000 17.22424 ? 353  TYR A CG  1 
ATOM   2989 C CD1 . TYR A  1 354 ? 17.15535  -9.81822  44.72384  1.000 20.18692 ? 353  TYR A CD1 1 
ATOM   2990 C CD2 . TYR A  1 354 ? 14.96866  -8.91157  44.98323  1.000 18.72807 ? 353  TYR A CD2 1 
ATOM   2991 C CE1 . TYR A  1 354 ? 16.96520  -10.61400 45.86049  1.000 23.21860 ? 353  TYR A CE1 1 
ATOM   2992 C CE2 . TYR A  1 354 ? 14.77587  -9.69563  46.11501  1.000 21.82092 ? 353  TYR A CE2 1 
ATOM   2993 C CZ  . TYR A  1 354 ? 15.76623  -10.54715 46.53671  1.000 23.46602 ? 353  TYR A CZ  1 
ATOM   2994 O OH  . TYR A  1 354 ? 15.57267  -11.32815 47.66201  1.000 29.50846 ? 353  TYR A OH  1 
ATOM   2995 N N   . GLY A  1 355 ? 17.82233  -5.12997  41.80674  1.000 19.97915 ? 354  GLY A N   1 
ATOM   2996 C CA  . GLY A  1 355 ? 18.25481  -4.41241  40.62435  1.000 19.76293 ? 354  GLY A CA  1 
ATOM   2997 C C   . GLY A  1 355 ? 17.19687  -4.12120  39.57653  1.000 19.52067 ? 354  GLY A C   1 
ATOM   2998 O O   . GLY A  1 355 ? 17.55602  -3.73015  38.45856  1.000 21.82369 ? 354  GLY A O   1 
ATOM   2999 N N   . TYR A  1 356 ? 15.91252  -4.27635  39.89352  1.000 17.73704 ? 355  TYR A N   1 
ATOM   3000 C CA  . TYR A  1 356 ? 14.86427  -3.98142  38.92078  1.000 19.10608 ? 355  TYR A CA  1 
ATOM   3001 C C   . TYR A  1 356 ? 14.40369  -2.53352  39.01875  1.000 21.20516 ? 355  TYR A C   1 
ATOM   3002 O O   . TYR A  1 356 ? 14.38467  -1.93658  40.10302  1.000 21.45357 ? 355  TYR A O   1 
ATOM   3003 C CB  . TYR A  1 356 ? 13.65186  -4.89698  39.12379  1.000 17.05712 ? 355  TYR A CB  1 
ATOM   3004 C CG  . TYR A  1 356 ? 13.97178  -6.35038  38.91880  1.000 16.78098 ? 355  TYR A CG  1 
ATOM   3005 C CD1 . TYR A  1 356 ? 14.02847  -6.89873  37.63238  1.000 15.95922 ? 355  TYR A CD1 1 
ATOM   3006 C CD2 . TYR A  1 356 ? 14.22929  -7.17877  40.00411  1.000 18.35778 ? 355  TYR A CD2 1 
ATOM   3007 C CE1 . TYR A  1 356 ? 14.34055  -8.22939  37.44858  1.000 18.22678 ? 355  TYR A CE1 1 
ATOM   3008 C CE2 . TYR A  1 356 ? 14.52929  -8.51017  39.83166  1.000 17.07336 ? 355  TYR A CE2 1 
ATOM   3009 C CZ  . TYR A  1 356 ? 14.58889  -9.02923  38.54344  1.000 18.06271 ? 355  TYR A CZ  1 
ATOM   3010 O OH  . TYR A  1 356 ? 14.89678  -10.35639 38.38235  1.000 17.16066 ? 355  TYR A OH  1 
ATOM   3011 N N   A GLN A  1 357 ? 14.08995  -1.96122  37.85811  0.493 19.75440 ? 356  GLN A N   1 
ATOM   3012 N N   B GLN A  1 357 ? 13.98317  -1.98493  37.88692  0.507 19.75351 ? 356  GLN A N   1 
ATOM   3013 C CA  A GLN A  1 357 ? 13.31972  -0.73208  37.74125  0.493 19.94191 ? 356  GLN A CA  1 
ATOM   3014 C CA  B GLN A  1 357 ? 13.27838  -0.71242  37.85131  0.507 19.89302 ? 356  GLN A CA  1 
ATOM   3015 C C   A GLN A  1 357 ? 11.90510  -1.09336  37.30749  0.493 19.59980 ? 356  GLN A C   1 
ATOM   3016 C C   B GLN A  1 357 ? 11.92086  -0.93735  37.20357  0.507 19.63745 ? 356  GLN A C   1 
ATOM   3017 O O   A GLN A  1 357 ? 11.70909  -2.01690  36.51345  0.493 16.80491 ? 356  GLN A O   1 
ATOM   3018 O O   B GLN A  1 357 ? 11.84269  -1.50316  36.10903  0.507 18.01059 ? 356  GLN A O   1 
ATOM   3019 C CB  A GLN A  1 357 ? 13.92491  0.23178   36.71108  0.493 23.51812 ? 356  GLN A CB  1 
ATOM   3020 C CB  B GLN A  1 357 ? 14.07121  0.34694   37.08026  0.507 23.69995 ? 356  GLN A CB  1 
ATOM   3021 C CG  A GLN A  1 357 ? 15.38665  0.63065   36.90107  0.493 26.20885 ? 356  GLN A CG  1 
ATOM   3022 C CG  B GLN A  1 357 ? 13.24844  1.56524   36.70150  0.507 25.92148 ? 356  GLN A CG  1 
ATOM   3023 C CD  A GLN A  1 357 ? 15.99262  1.18757   35.61096  0.493 32.01405 ? 356  GLN A CD  1 
ATOM   3024 C CD  B GLN A  1 357 ? 14.09177  2.71199   36.17123  0.507 33.91211 ? 356  GLN A CD  1 
ATOM   3025 O OE1 A GLN A  1 357 ? 17.06605  0.76519   35.16599  0.493 22.54341 ? 356  GLN A OE1 1 
ATOM   3026 O OE1 B GLN A  1 357 ? 15.12817  2.49509   35.54920  0.507 28.07004 ? 356  GLN A OE1 1 
ATOM   3027 N NE2 A GLN A  1 357 ? 15.29167  2.13641   34.99925  0.493 33.26268 ? 356  GLN A NE2 1 
ATOM   3028 N NE2 B GLN A  1 357 ? 13.64760  3.94207   36.41901  0.507 31.17622 ? 356  GLN A NE2 1 
ATOM   3029 N N   A ARG A  1 358 ? 10.92258  -0.36897  37.82907  0.493 19.97355 ? 357  ARG A N   1 
ATOM   3030 N N   B ARG A  1 358 ? 10.85543  -0.52093  37.88449  0.507 19.80222 ? 357  ARG A N   1 
ATOM   3031 C CA  A ARG A  1 358 ? 9.54752   -0.47010  37.35762  0.493 19.36389 ? 357  ARG A CA  1 
ATOM   3032 C CA  B ARG A  1 358 ? 9.52273   -0.60122  37.29953  0.507 19.30475 ? 357  ARG A CA  1 
ATOM   3033 C C   A ARG A  1 358 ? 9.30289   0.65490   36.36204  0.493 21.74643 ? 357  ARG A C   1 
ATOM   3034 C C   B ARG A  1 358 ? 9.30322   0.58686   36.37563  0.507 21.68924 ? 357  ARG A C   1 
ATOM   3035 O O   A ARG A  1 358 ? 9.40912   1.83330   36.71593  0.493 19.98139 ? 357  ARG A O   1 
ATOM   3036 O O   B ARG A  1 358 ? 9.42197   1.74267   36.79405  0.507 20.14528 ? 357  ARG A O   1 
ATOM   3037 C CB  A ARG A  1 358 ? 8.56454   -0.39460  38.52776  0.493 20.53088 ? 357  ARG A CB  1 
ATOM   3038 C CB  B ARG A  1 358 ? 8.44665   -0.64729  38.38125  0.507 20.88441 ? 357  ARG A CB  1 
ATOM   3039 C CG  A ARG A  1 358 ? 7.16343   -0.91464  38.22202  0.493 21.28202 ? 357  ARG A CG  1 
ATOM   3040 C CG  B ARG A  1 358 ? 7.02776   -0.63410  37.81493  0.507 18.10530 ? 357  ARG A CG  1 
ATOM   3041 C CD  A ARG A  1 358 ? 6.30258   0.17010   37.61253  0.493 17.74318 ? 357  ARG A CD  1 
ATOM   3042 C CD  B ARG A  1 358 ? 5.99953   -0.33937  38.89589  0.507 15.47620 ? 357  ARG A CD  1 
ATOM   3043 N NE  A ARG A  1 358 ? 4.87343   -0.06316  37.78633  0.493 22.27193 ? 357  ARG A NE  1 
ATOM   3044 N NE  B ARG A  1 358 ? 4.63530   -0.33371  38.37893  0.507 16.33267 ? 357  ARG A NE  1 
ATOM   3045 C CZ  A ARG A  1 358 ? 3.94019   0.82681   37.47754  0.493 22.22000 ? 357  ARG A CZ  1 
ATOM   3046 C CZ  B ARG A  1 358 ? 4.06933   0.72669   37.81769  0.507 22.31807 ? 357  ARG A CZ  1 
ATOM   3047 N NH1 A ARG A  1 358 ? 4.25724   2.01541   36.99100  0.493 21.04519 ? 357  ARG A NH1 1 
ATOM   3048 N NH1 B ARG A  1 358 ? 4.72889   1.86557   37.67787  0.507 20.52670 ? 357  ARG A NH1 1 
ATOM   3049 N NH2 A ARG A  1 358 ? 2.65837   0.51411   37.65202  0.493 20.06822 ? 357  ARG A NH2 1 
ATOM   3050 N NH2 B ARG A  1 358 ? 2.81641   0.64052   37.37550  0.507 19.59522 ? 357  ARG A NH2 1 
ATOM   3051 N N   . LEU A  1 359 ? 8.98817   0.30013   35.11824  1.000 17.97497 ? 358  LEU A N   1 
ATOM   3052 C CA  . LEU A  1 359 ? 8.74285   1.30106   34.09623  1.000 19.21542 ? 358  LEU A CA  1 
ATOM   3053 C C   . LEU A  1 359 ? 7.31374   1.14740   33.59182  1.000 18.31976 ? 358  LEU A C   1 
ATOM   3054 O O   . LEU A  1 359 ? 6.64350   0.14802   33.86051  1.000 19.90989 ? 358  LEU A O   1 
ATOM   3055 C CB  . LEU A  1 359 ? 9.76386   1.17604   32.96133  1.000 19.69331 ? 358  LEU A CB  1 
ATOM   3056 C CG  . LEU A  1 359 ? 11.20901  1.32147   33.45563  1.000 22.91996 ? 358  LEU A CG  1 
ATOM   3057 C CD1 . LEU A  1 359 ? 12.20598  0.84038   32.41144  1.000 24.16947 ? 358  LEU A CD1 1 
ATOM   3058 C CD2 . LEU A  1 359 ? 11.48129  2.77607   33.79779  1.000 25.17298 ? 358  LEU A CD2 1 
ATOM   3059 N N   . TRP A  1 360 ? 6.84085   2.16412   32.87924  1.000 19.92407 ? 359  TRP A N   1 
ATOM   3060 C CA  . TRP A  1 360 ? 5.45366   2.22593   32.44082  1.000 19.92313 ? 359  TRP A CA  1 
ATOM   3061 C C   . TRP A  1 360 ? 5.41499   2.64711   30.98654  1.000 22.40418 ? 359  TRP A C   1 
ATOM   3062 O O   . TRP A  1 360 ? 6.04796   3.63384   30.60781  1.000 21.35448 ? 359  TRP A O   1 
ATOM   3063 C CB  . TRP A  1 360 ? 4.65179   3.21881   33.29043  1.000 20.91298 ? 359  TRP A CB  1 
ATOM   3064 C CG  . TRP A  1 360 ? 3.22295   3.38427   32.86236  1.000 18.78480 ? 359  TRP A CG  1 
ATOM   3065 C CD1 . TRP A  1 360 ? 2.70204   4.37160   32.05599  1.000 20.16130 ? 359  TRP A CD1 1 
ATOM   3066 C CD2 . TRP A  1 360 ? 2.12641   2.53383   33.21405  1.000 20.89480 ? 359  TRP A CD2 1 
ATOM   3067 N NE1 . TRP A  1 360 ? 1.34655   4.18348   31.90221  1.000 19.33892 ? 359  TRP A NE1 1 
ATOM   3068 C CE2 . TRP A  1 360 ? 0.97086   3.06263   32.59966  1.000 17.70168 ? 359  TRP A CE2 1 
ATOM   3069 C CE3 . TRP A  1 360 ? 2.00871   1.37689   33.99681  1.000 21.19026 ? 359  TRP A CE3 1 
ATOM   3070 C CZ2 . TRP A  1 360 ? -0.28584  2.46795   32.73576  1.000 19.13251 ? 359  TRP A CZ2 1 
ATOM   3071 C CZ3 . TRP A  1 360 ? 0.75304   0.79369   34.14594  1.000 19.32448 ? 359  TRP A CZ3 1 
ATOM   3072 C CH2 . TRP A  1 360 ? -0.37582  1.34164   33.51764  1.000 18.53118 ? 359  TRP A CH2 1 
ATOM   3073 N N   . ASN A  1 361 ? 4.67991   1.90939   30.17164  1.000 19.91208 ? 360  ASN A N   1 
ATOM   3074 C CA  . ASN A  1 361 ? 4.47897   2.29228   28.78298  1.000 17.97433 ? 360  ASN A CA  1 
ATOM   3075 C C   . ASN A  1 361 ? 3.10781   2.94800   28.69902  1.000 19.61315 ? 360  ASN A C   1 
ATOM   3076 O O   . ASN A  1 361 ? 2.08727   2.28968   28.92173  1.000 19.25367 ? 360  ASN A O   1 
ATOM   3077 C CB  . ASN A  1 361 ? 4.59775   1.08315   27.85590  1.000 17.70001 ? 360  ASN A CB  1 
ATOM   3078 C CG  . ASN A  1 361 ? 4.50963   1.47159   26.39176  1.000 17.92346 ? 360  ASN A CG  1 
ATOM   3079 O OD1 . ASN A  1 361 ? 3.57653   2.15754   25.98542  1.000 20.18538 ? 360  ASN A OD1 1 
ATOM   3080 N ND2 . ASN A  1 361 ? 5.49777   1.05662   25.59485  1.000 18.65582 ? 360  ASN A ND2 1 
ATOM   3081 N N   A ASP A  1 362 ? 3.09735   4.24715   28.38591  0.615 20.30254 ? 361  ASP A N   1 
ATOM   3082 N N   B ASP A  1 362 ? 3.07578   4.25098   28.40405  0.385 20.41175 ? 361  ASP A N   1 
ATOM   3083 C CA  A ASP A  1 362 ? 1.88287   5.04973   28.36938  0.615 24.19968 ? 361  ASP A CA  1 
ATOM   3084 C CA  B ASP A  1 362 ? 1.80351   4.96577   28.42568  0.385 24.06446 ? 361  ASP A CA  1 
ATOM   3085 C C   A ASP A  1 362 ? 1.00812   4.76821   27.15722  0.615 22.28935 ? 361  ASP A C   1 
ATOM   3086 C C   B ASP A  1 362 ? 1.02576   4.83924   27.11955  0.385 22.31776 ? 361  ASP A C   1 
ATOM   3087 O O   A ASP A  1 362 ? -0.15537  5.18152   27.14512  0.615 22.96806 ? 361  ASP A O   1 
ATOM   3088 O O   B ASP A  1 362 ? -0.04529  5.44254   26.99858  0.385 23.04559 ? 361  ASP A O   1 
ATOM   3089 C CB  A ASP A  1 362 ? 2.24131   6.53818   28.39769  0.615 27.61214 ? 361  ASP A CB  1 
ATOM   3090 C CB  B ASP A  1 362 ? 2.01100   6.44934   28.78087  0.385 26.53485 ? 361  ASP A CB  1 
ATOM   3091 C CG  A ASP A  1 362 ? 1.51819   7.28848   29.48543  0.615 34.15476 ? 361  ASP A CG  1 
ATOM   3092 C CG  B ASP A  1 362 ? 2.92054   7.18784   27.79997  0.385 32.13957 ? 361  ASP A CG  1 
ATOM   3093 O OD1 A ASP A  1 362 ? 1.83083   7.04230   30.66651  0.615 47.51185 ? 361  ASP A OD1 1 
ATOM   3094 O OD1 B ASP A  1 362 ? 2.90538   6.88340   26.58812  0.385 33.35934 ? 361  ASP A OD1 1 
ATOM   3095 O OD2 A ASP A  1 362 ? 0.63980   8.12479   29.17727  0.615 35.58415 ? 361  ASP A OD2 1 
ATOM   3096 O OD2 B ASP A  1 362 ? 3.65590   8.09542   28.24854  0.385 36.37312 ? 361  ASP A OD2 1 
ATOM   3097 N N   . LYS A  1 363 ? 1.53763   4.08854   26.14383  1.000 19.37143 ? 362  LYS A N   1 
ATOM   3098 C CA  A LYS A  1 363 ? 0.73304   3.71514   24.98507  0.565 21.69883 ? 362  LYS A CA  1 
ATOM   3099 C CA  B LYS A  1 363 ? 0.74117   3.71140   24.97995  0.435 21.71248 ? 362  LYS A CA  1 
ATOM   3100 C C   . LYS A  1 363 ? 0.00955   2.39589   25.22673  1.000 20.51710 ? 362  LYS A C   1 
ATOM   3101 O O   . LYS A  1 363 ? -1.20741  2.30690   25.03758  1.000 20.78454 ? 362  LYS A O   1 
ATOM   3102 C CB  A LYS A  1 363 ? 1.60849   3.61560   23.73133  0.565 21.47814 ? 362  LYS A CB  1 
ATOM   3103 C CB  B LYS A  1 363 ? 1.62630   3.58929   23.73515  0.435 21.50874 ? 362  LYS A CB  1 
ATOM   3104 C CG  A LYS A  1 363 ? 2.29745   4.92126   23.32589  0.565 27.53101 ? 362  LYS A CG  1 
ATOM   3105 C CG  B LYS A  1 363 ? 2.42931   4.83926   23.38353  0.435 27.58811 ? 362  LYS A CG  1 
ATOM   3106 C CD  A LYS A  1 363 ? 1.41142   5.77819   22.43000  0.565 27.97825 ? 362  LYS A CD  1 
ATOM   3107 C CD  B LYS A  1 363 ? 1.53095   5.97970   22.93894  0.435 28.97204 ? 362  LYS A CD  1 
ATOM   3108 C CE  A LYS A  1 363 ? 2.20491   6.92551   21.80107  0.565 32.40087 ? 362  LYS A CE  1 
ATOM   3109 C CE  B LYS A  1 363 ? 2.31687   7.03585   22.16365  0.435 32.11324 ? 362  LYS A CE  1 
ATOM   3110 N NZ  A LYS A  1 363 ? 1.34445   7.85475   21.00557  0.565 31.25445 ? 362  LYS A NZ  1 
ATOM   3111 N NZ  B LYS A  1 363 ? 3.52933   6.47506   21.50407  0.435 35.72020 ? 362  LYS A NZ  1 
ATOM   3112 N N   . THR A  1 364 ? 0.74638   1.36910   25.66634  1.000 18.86814 ? 363  THR A N   1 
ATOM   3113 C CA  . THR A  1 364 ? 0.14436   0.07615   25.96359  1.000 18.95332 ? 363  THR A CA  1 
ATOM   3114 C C   . THR A  1 364 ? -0.63742  0.08781   27.26821  1.000 17.22145 ? 363  THR A C   1 
ATOM   3115 O O   . THR A  1 364 ? -1.47268  -0.79862  27.47928  1.000 17.69476 ? 363  THR A O   1 
ATOM   3116 C CB  . THR A  1 364 ? 1.22174   -1.01233  26.02861  1.000 17.03285 ? 363  THR A CB  1 
ATOM   3117 O OG1 . THR A  1 364 ? 2.11058   -0.75178  27.12941  1.000 18.60950 ? 363  THR A OG1 1 
ATOM   3118 C CG2 . THR A  1 364 ? 2.01128   -1.07412  24.70974  1.000 18.23532 ? 363  THR A CG2 1 
ATOM   3119 N N   . LYS A  1 365 ? -0.37125  1.06756   28.13670  1.000 17.53103 ? 364  LYS A N   1 
ATOM   3120 C CA  . LYS A  1 365 ? -0.96143  1.15569   29.47371  1.000 17.43059 ? 364  LYS A CA  1 
ATOM   3121 C C   . LYS A  1 365 ? -0.62062  -0.07374  30.30917  1.000 17.40333 ? 364  LYS A C   1 
ATOM   3122 O O   . LYS A  1 365 ? -1.47180  -0.61458  31.02290  1.000 17.64596 ? 364  LYS A O   1 
ATOM   3123 C CB  . LYS A  1 365 ? -2.47740  1.36940   29.41033  1.000 19.10904 ? 364  LYS A CB  1 
ATOM   3124 C CG  . LYS A  1 365 ? -2.89532  2.67416   28.71171  1.000 17.75404 ? 364  LYS A CG  1 
ATOM   3125 C CD  . LYS A  1 365 ? -2.41313  3.90494   29.49620  1.000 22.32827 ? 364  LYS A CD  1 
ATOM   3126 C CE  . LYS A  1 365 ? -2.86428  5.20831   28.80186  1.000 23.13762 ? 364  LYS A CE  1 
ATOM   3127 N NZ  . LYS A  1 365 ? -2.54088  6.39946   29.66759  1.000 28.62834 ? 364  LYS A NZ  1 
ATOM   3128 N N   . THR A  1 366 ? 0.63628   -0.51437  30.23330  1.000 18.21214 ? 365  THR A N   1 
ATOM   3129 C CA  . THR A  1 366 ? 1.07768   -1.65555  31.02205  1.000 16.44707 ? 365  THR A CA  1 
ATOM   3130 C C   . THR A  1 366 ? 2.44907   -1.39547  31.62074  1.000 16.31299 ? 365  THR A C   1 
ATOM   3131 O O   . THR A  1 366 ? 3.27012   -0.68100  31.02879  1.000 17.89707 ? 365  THR A O   1 
ATOM   3132 C CB  . THR A  1 366 ? 1.13813   -2.95851  30.19711  1.000 18.61061 ? 365  THR A CB  1 
ATOM   3133 O OG1 . THR A  1 366 ? 1.93783   -2.76224  29.02193  1.000 17.99289 ? 365  THR A OG1 1 
ATOM   3134 C CG2 . THR A  1 366 ? -0.27403  -3.44007  29.81896  1.000 18.23842 ? 365  THR A CG2 1 
ATOM   3135 N N   . PRO A  1 367 ? 2.72863   -1.98306  32.77814  1.000 17.26138 ? 366  PRO A N   1 
ATOM   3136 C CA  . PRO A  1 367 ? 4.04275   -1.84884  33.40865  1.000 18.60856 ? 366  PRO A CA  1 
ATOM   3137 C C   . PRO A  1 367 ? 5.02284   -2.89502  32.89000  1.000 18.43105 ? 366  PRO A C   1 
ATOM   3138 O O   . PRO A  1 367 ? 4.63804   -3.90662  32.30480  1.000 16.72242 ? 366  PRO A O   1 
ATOM   3139 C CB  . PRO A  1 367 ? 3.73078   -2.11811  34.88600  1.000 16.77393 ? 366  PRO A CB  1 
ATOM   3140 C CG  . PRO A  1 367 ? 2.64929   -3.18502  34.81562  1.000 16.39507 ? 366  PRO A CG  1 
ATOM   3141 C CD  . PRO A  1 367 ? 1.79556   -2.77117  33.60465  1.000 15.16842 ? 366  PRO A CD  1 
ATOM   3142 N N   . TYR A  1 368 ? 6.30191   -2.66144  33.17993  1.000 17.27711 ? 367  TYR A N   1 
ATOM   3143 C CA  . TYR A  1 368 ? 7.33047   -3.66015  32.91162  1.000 15.41807 ? 367  TYR A CA  1 
ATOM   3144 C C   . TYR A  1 368 ? 8.50665   -3.45342  33.85606  1.000 20.30800 ? 367  TYR A C   1 
ATOM   3145 O O   . TYR A  1 368 ? 8.75263   -2.34343  34.33477  1.000 18.66333 ? 367  TYR A O   1 
ATOM   3146 C CB  . TYR A  1 368 ? 7.80608   -3.63720  31.44669  1.000 17.20793 ? 367  TYR A CB  1 
ATOM   3147 C CG  . TYR A  1 368 ? 8.30753   -2.30788  30.90642  1.000 17.11371 ? 367  TYR A CG  1 
ATOM   3148 C CD1 . TYR A  1 368 ? 7.43354   -1.25750  30.62806  1.000 17.27507 ? 367  TYR A CD1 1 
ATOM   3149 C CD2 . TYR A  1 368 ? 9.66065   -2.11653  30.63704  1.000 17.87945 ? 367  TYR A CD2 1 
ATOM   3150 C CE1 . TYR A  1 368 ? 7.90466   -0.04268  30.09687  1.000 18.11035 ? 367  TYR A CE1 1 
ATOM   3151 C CE2 . TYR A  1 368 ? 10.13091  -0.91981  30.10157  1.000 18.91773 ? 367  TYR A CE2 1 
ATOM   3152 C CZ  . TYR A  1 368 ? 9.25142   0.10862   29.83821  1.000 20.11215 ? 367  TYR A CZ  1 
ATOM   3153 O OH  . TYR A  1 368 ? 9.74463   1.29225   29.33719  1.000 23.49549 ? 367  TYR A OH  1 
ATOM   3154 N N   . LEU A  1 369 ? 9.21608   -4.53737  34.15222  1.000 18.39001 ? 368  LEU A N   1 
ATOM   3155 C CA  . LEU A  1 369 ? 10.45303  -4.43409  34.91830  1.000 17.77832 ? 368  LEU A CA  1 
ATOM   3156 C C   . LEU A  1 369 ? 11.63725  -4.49740  33.96996  1.000 20.18706 ? 368  LEU A C   1 
ATOM   3157 O O   . LEU A  1 369 ? 11.63619  -5.26857  33.00597  1.000 19.51852 ? 368  LEU A O   1 
ATOM   3158 C CB  . LEU A  1 369 ? 10.59637  -5.54378  35.95413  1.000 15.20078 ? 368  LEU A CB  1 
ATOM   3159 C CG  . LEU A  1 369 ? 9.49173   -5.71711  36.98206  1.000 18.97108 ? 368  LEU A CG  1 
ATOM   3160 C CD1 . LEU A  1 369 ? 9.94846   -6.72205  38.03585  1.000 17.99974 ? 368  LEU A CD1 1 
ATOM   3161 C CD2 . LEU A  1 369 ? 9.14094   -4.35018  37.60928  1.000 19.90607 ? 368  LEU A CD2 1 
ATOM   3162 N N   . TYR A  1 370 ? 12.66164  -3.70710  34.26927  1.000 16.25305 ? 369  TYR A N   1 
ATOM   3163 C CA  . TYR A  1 370 ? 13.90243  -3.72936  33.51228  1.000 15.84803 ? 369  TYR A CA  1 
ATOM   3164 C C   . TYR A  1 370 ? 15.04581  -3.91228  34.49859  1.000 20.84673 ? 369  TYR A C   1 
ATOM   3165 O O   . TYR A  1 370 ? 15.11573  -3.19685  35.50580  1.000 19.54885 ? 369  TYR A O   1 
ATOM   3166 C CB  . TYR A  1 370 ? 14.05746  -2.44612  32.70708  1.000 17.84883 ? 369  TYR A CB  1 
ATOM   3167 C CG  . TYR A  1 370 ? 15.35311  -2.34107  31.96053  1.000 19.64610 ? 369  TYR A CG  1 
ATOM   3168 C CD1 . TYR A  1 370 ? 15.76816  -3.35940  31.09867  1.000 18.60432 ? 369  TYR A CD1 1 
ATOM   3169 C CD2 . TYR A  1 370 ? 16.15569  -1.21682  32.09210  1.000 20.31095 ? 369  TYR A CD2 1 
ATOM   3170 C CE1 . TYR A  1 370 ? 16.97271  -3.26017  30.39896  1.000 20.96354 ? 369  TYR A CE1 1 
ATOM   3171 C CE2 . TYR A  1 370 ? 17.34963  -1.10759  31.40203  1.000 22.48791 ? 369  TYR A CE2 1 
ATOM   3172 C CZ  . TYR A  1 370 ? 17.75173  -2.13188  30.56175  1.000 27.53935 ? 369  TYR A CZ  1 
ATOM   3173 O OH  . TYR A  1 370 ? 18.93491  -2.01660  29.87843  1.000 24.29569 ? 369  TYR A OH  1 
ATOM   3174 N N   . HIS A  1 371 ? 15.90439  -4.89811  34.23359  1.000 18.15203 ? 370  HIS A N   1 
ATOM   3175 C CA  . HIS A  1 371 ? 17.11041  -5.15122  35.02939  1.000 16.63076 ? 370  HIS A CA  1 
ATOM   3176 C C   . HIS A  1 371 ? 18.28518  -4.74422  34.15004  1.000 19.53631 ? 370  HIS A C   1 
ATOM   3177 O O   . HIS A  1 371 ? 18.71857  -5.50299  33.27030  1.000 18.60473 ? 370  HIS A O   1 
ATOM   3178 C CB  . HIS A  1 371 ? 17.18638  -6.60939  35.46975  1.000 17.13425 ? 370  HIS A CB  1 
ATOM   3179 C CG  . HIS A  1 371 ? 18.20056  -6.87293  36.53750  1.000 16.84309 ? 370  HIS A CG  1 
ATOM   3180 N ND1 . HIS A  1 371 ? 19.55652  -6.89542  36.28962  1.000 18.12934 ? 370  HIS A ND1 1 
ATOM   3181 C CD2 . HIS A  1 371 ? 18.05112  -7.14795  37.85613  1.000 17.60372 ? 370  HIS A CD2 1 
ATOM   3182 C CE1 . HIS A  1 371 ? 20.19968  -7.16583  37.41440  1.000 20.43587 ? 370  HIS A CE1 1 
ATOM   3183 N NE2 . HIS A  1 371 ? 19.30817  -7.32698  38.37769  1.000 20.97243 ? 370  HIS A NE2 1 
ATOM   3184 N N   . ALA A  1 372 ? 18.77635  -3.52273  34.37119  1.000 17.24329 ? 371  ALA A N   1 
ATOM   3185 C CA  . ALA A  1 372 ? 19.76681  -2.95340  33.46084  1.000 19.86090 ? 371  ALA A CA  1 
ATOM   3186 C C   . ALA A  1 372 ? 21.09942  -3.68428  33.55891  1.000 19.17088 ? 371  ALA A C   1 
ATOM   3187 O O   . ALA A  1 372 ? 21.78447  -3.87066  32.54513  1.000 21.34990 ? 371  ALA A O   1 
ATOM   3188 C CB  . ALA A  1 372 ? 19.94785  -1.46508  33.74871  1.000 22.63982 ? 371  ALA A CB  1 
ATOM   3189 N N   . GLN A  1 373 ? 21.47332  -4.13085  34.75994  1.000 19.81175 ? 372  GLN A N   1 
ATOM   3190 C CA  . GLN A  1 373 ? 22.77967  -4.76072  34.91768  1.000 20.00150 ? 372  GLN A CA  1 
ATOM   3191 C C   . GLN A  1 373 ? 22.85415  -6.09598  34.18826  1.000 19.99111 ? 372  GLN A C   1 
ATOM   3192 O O   . GLN A  1 373 ? 23.85046  -6.38494  33.51487  1.000 20.85746 ? 372  GLN A O   1 
ATOM   3193 C CB  . GLN A  1 373 ? 23.11197  -4.96470  36.39064  1.000 19.52798 ? 372  GLN A CB  1 
ATOM   3194 C CG  . GLN A  1 373 ? 24.44935  -5.69501  36.55871  1.000 22.86517 ? 372  GLN A CG  1 
ATOM   3195 C CD  . GLN A  1 373 ? 24.95144  -5.70610  37.97799  1.000 36.49797 ? 372  GLN A CD  1 
ATOM   3196 O OE1 . GLN A  1 373 ? 24.24693  -5.30377  38.89674  1.000 29.61299 ? 372  GLN A OE1 1 
ATOM   3197 N NE2 . GLN A  1 373 ? 26.17112  -6.19025  38.16935  1.000 35.04585 ? 372  GLN A NE2 1 
ATOM   3198 N N   . ASN A  1 374 ? 21.82767  -6.93402  34.31815  1.000 18.26735 ? 373  ASN A N   1 
ATOM   3199 C CA  . ASN A  1 374 ? 21.90424  -8.26807  33.73705  1.000 15.02539 ? 373  ASN A CA  1 
ATOM   3200 C C   . ASN A  1 374 ? 21.21417  -8.36620  32.38857  1.000 17.80581 ? 373  ASN A C   1 
ATOM   3201 O O   . ASN A  1 374 ? 21.40888  -9.36537  31.68575  1.000 19.77655 ? 373  ASN A O   1 
ATOM   3202 C CB  . ASN A  1 374 ? 21.30516  -9.30786  34.69232  1.000 17.18697 ? 373  ASN A CB  1 
ATOM   3203 C CG  . ASN A  1 374 ? 22.15766  -9.51378  35.93571  1.000 19.68549 ? 373  ASN A CG  1 
ATOM   3204 O OD1 . ASN A  1 374 ? 23.12615  -8.78595  36.15929  1.000 19.75582 ? 373  ASN A OD1 1 
ATOM   3205 N ND2 . ASN A  1 374 ? 21.81677  -10.51587 36.73514  1.000 18.69228 ? 373  ASN A ND2 1 
ATOM   3206 N N   . GLY A  1 375 ? 20.43788  -7.35470  32.00759  1.000 16.03926 ? 374  GLY A N   1 
ATOM   3207 C CA  . GLY A  1 375 ? 19.69998  -7.38362  30.75565  1.000 16.85793 ? 374  GLY A CA  1 
ATOM   3208 C C   . GLY A  1 375 ? 18.47650  -8.27393  30.84390  1.000 19.99349 ? 374  GLY A C   1 
ATOM   3209 O O   . GLY A  1 375 ? 18.33540  -9.22961  30.07113  1.000 17.65217 ? 374  GLY A O   1 
ATOM   3210 N N   . LEU A  1 376 ? 17.58367  -7.98036  31.79038  1.000 16.01906 ? 375  LEU A N   1 
ATOM   3211 C CA  . LEU A  1 376 ? 16.33050  -8.70638  31.95408  1.000 14.07876 ? 375  LEU A CA  1 
ATOM   3212 C C   . LEU A  1 376 ? 15.15391  -7.77046  31.70763  1.000 17.79532 ? 375  LEU A C   1 
ATOM   3213 O O   . LEU A  1 376 ? 15.21938  -6.56913  31.99929  1.000 16.86263 ? 375  LEU A O   1 
ATOM   3214 C CB  . LEU A  1 376 ? 16.20606  -9.30882  33.37358  1.000 14.92598 ? 375  LEU A CB  1 
ATOM   3215 C CG  . LEU A  1 376 ? 17.42252  -10.03506 33.94706  1.000 16.99805 ? 375  LEU A CG  1 
ATOM   3216 C CD1 . LEU A  1 376 ? 17.09943  -10.53573 35.35288  1.000 16.15091 ? 375  LEU A CD1 1 
ATOM   3217 C CD2 . LEU A  1 376 ? 17.85634  -11.18562 33.03866  1.000 16.82691 ? 375  LEU A CD2 1 
ATOM   3218 N N   . PHE A  1 377 ? 14.07703  -8.33126  31.15459  1.000 16.47554 ? 376  PHE A N   1 
ATOM   3219 C CA  . PHE A  1 377 ? 12.84060  -7.60618  30.86942  1.000 15.80310 ? 376  PHE A CA  1 
ATOM   3220 C C   . PHE A  1 377 ? 11.67883  -8.46842  31.34090  1.000 17.51618 ? 376  PHE A C   1 
ATOM   3221 O O   . PHE A  1 377 ? 11.66081  -9.67487  31.07699  1.000 15.74265 ? 376  PHE A O   1 
ATOM   3222 C CB  . PHE A  1 377 ? 12.72168  -7.30637  29.36308  1.000 13.84948 ? 376  PHE A CB  1 
ATOM   3223 C CG  . PHE A  1 377 ? 11.35811  -6.82592  28.92939  1.000 14.55362 ? 376  PHE A CG  1 
ATOM   3224 C CD1 . PHE A  1 377 ? 10.99360  -5.49207  29.07578  1.000 17.41214 ? 376  PHE A CD1 1 
ATOM   3225 C CD2 . PHE A  1 377 ? 10.45936  -7.70718  28.32987  1.000 17.41134 ? 376  PHE A CD2 1 
ATOM   3226 C CE1 . PHE A  1 377 ? 9.74175   -5.04135  28.65472  1.000 17.81274 ? 376  PHE A CE1 1 
ATOM   3227 C CE2 . PHE A  1 377 ? 9.21076   -7.27286  27.90508  1.000 16.76162 ? 376  PHE A CE2 1 
ATOM   3228 C CZ  . PHE A  1 377 ? 8.84793   -5.93936  28.06720  1.000 19.13300 ? 376  PHE A CZ  1 
ATOM   3229 N N   . VAL A  1 378 ? 10.72304  -7.87042  32.05031  1.000 15.42822 ? 377  VAL A N   1 
ATOM   3230 C CA  . VAL A  1 378 ? 9.55157   -8.60152  32.52670  1.000 13.62836 ? 377  VAL A CA  1 
ATOM   3231 C C   . VAL A  1 378 ? 8.31221   -7.82237  32.12208  1.000 20.01825 ? 377  VAL A C   1 
ATOM   3232 O O   . VAL A  1 378 ? 8.18591   -6.64611  32.46581  1.000 17.35139 ? 377  VAL A O   1 
ATOM   3233 C CB  . VAL A  1 378 ? 9.55386   -8.80642  34.05201  1.000 17.10968 ? 377  VAL A CB  1 
ATOM   3234 C CG1 . VAL A  1 378 ? 8.34914   -9.65253  34.44493  1.000 18.34305 ? 377  VAL A CG1 1 
ATOM   3235 C CG2 . VAL A  1 378 ? 10.86101  -9.46503  34.52455  1.000 14.68264 ? 377  VAL A CG2 1 
ATOM   3236 N N   . THR A  1 379 ? 7.39334   -8.47161  31.41076  1.000 17.22192 ? 378  THR A N   1 
ATOM   3237 C CA  . THR A  1 379 ? 6.10124   -7.87056  31.08967  1.000 14.99772 ? 378  THR A CA  1 
ATOM   3238 C C   . THR A  1 379 ? 5.02970   -8.45104  32.00478  1.000 16.16426 ? 378  THR A C   1 
ATOM   3239 O O   . THR A  1 379 ? 4.90975   -9.67154  32.12848  1.000 16.04360 ? 378  THR A O   1 
ATOM   3240 C CB  . THR A  1 379 ? 5.72772   -8.09300  29.61677  1.000 17.09622 ? 378  THR A CB  1 
ATOM   3241 O OG1 . THR A  1 379 ? 4.33078   -7.81124  29.43631  1.000 15.52391 ? 378  THR A OG1 1 
ATOM   3242 C CG2 . THR A  1 379 ? 6.04456   -9.52560  29.14728  1.000 14.73297 ? 378  THR A CG2 1 
ATOM   3243 N N   . TYR A  1 380 ? 4.25421   -7.58145  32.65142  1.000 17.06369 ? 379  TYR A N   1 
ATOM   3244 C CA  . TYR A  1 380 ? 3.25338   -8.05280  33.60398  1.000 17.33552 ? 379  TYR A CA  1 
ATOM   3245 C C   . TYR A  1 380 ? 2.13842   -7.02056  33.67681  1.000 16.16486 ? 379  TYR A C   1 
ATOM   3246 O O   . TYR A  1 380 ? 2.18620   -5.98553  33.00937  1.000 15.86388 ? 379  TYR A O   1 
ATOM   3247 C CB  . TYR A  1 380 ? 3.86894   -8.31669  34.99439  1.000 16.55732 ? 379  TYR A CB  1 
ATOM   3248 C CG  . TYR A  1 380 ? 4.31099   -7.07741  35.73638  1.000 17.67099 ? 379  TYR A CG  1 
ATOM   3249 C CD1 . TYR A  1 380 ? 5.42163   -6.34262  35.31446  1.000 17.77117 ? 379  TYR A CD1 1 
ATOM   3250 C CD2 . TYR A  1 380 ? 3.62076   -6.64069  36.86434  1.000 16.91514 ? 379  TYR A CD2 1 
ATOM   3251 C CE1 . TYR A  1 380 ? 5.82902   -5.19841  35.98674  1.000 20.73932 ? 379  TYR A CE1 1 
ATOM   3252 C CE2 . TYR A  1 380 ? 4.02906   -5.49469  37.56039  1.000 18.51656 ? 379  TYR A CE2 1 
ATOM   3253 C CZ  . TYR A  1 380 ? 5.12903   -4.78207  37.10856  1.000 20.96067 ? 379  TYR A CZ  1 
ATOM   3254 O OH  . TYR A  1 380 ? 5.52758   -3.64647  37.77978  1.000 19.41668 ? 379  TYR A OH  1 
ATOM   3255 N N   . ASP A  1 381 ? 1.13443   -7.30641  34.50594  1.000 15.30116 ? 380  ASP A N   1 
ATOM   3256 C CA  . ASP A  1 381 ? 0.02874   -6.39015  34.73952  1.000 15.63477 ? 380  ASP A CA  1 
ATOM   3257 C C   . ASP A  1 381 ? -0.07215  -6.10073  36.22915  1.000 16.06141 ? 380  ASP A C   1 
ATOM   3258 O O   . ASP A  1 381 ? 0.35964   -6.90260  37.05933  1.000 15.99419 ? 380  ASP A O   1 
ATOM   3259 C CB  . ASP A  1 381 ? -1.29040  -6.98038  34.24541  1.000 17.05477 ? 380  ASP A CB  1 
ATOM   3260 C CG  . ASP A  1 381 ? -1.54905  -6.66510  32.78299  1.000 19.36525 ? 380  ASP A CG  1 
ATOM   3261 O OD1 . ASP A  1 381 ? -0.98090  -7.36100  31.91121  1.000 19.29933 ? 380  ASP A OD1 1 
ATOM   3262 O OD2 . ASP A  1 381 ? -2.27729  -5.69099  32.50379  1.000 17.86072 ? 380  ASP A OD2 1 
ATOM   3263 N N   . ASP A  1 382 ? -0.66380  -4.95845  36.57064  1.000 16.60970 ? 381  ASP A N   1 
ATOM   3264 C CA  . ASP A  1 382 ? -0.80128  -4.61216  37.98957  1.000 14.45756 ? 381  ASP A CA  1 
ATOM   3265 C C   . ASP A  1 382 ? -2.08725  -3.81635  38.18550  1.000 16.68340 ? 381  ASP A C   1 
ATOM   3266 O O   . ASP A  1 382 ? -2.90027  -3.67746  37.26570  1.000 16.38670 ? 381  ASP A O   1 
ATOM   3267 C CB  . ASP A  1 382 ? 0.45619   -3.87802  38.48843  1.000 17.81471 ? 381  ASP A CB  1 
ATOM   3268 C CG  . ASP A  1 382 ? 0.65510   -2.50380  37.85732  1.000 18.57514 ? 381  ASP A CG  1 
ATOM   3269 O OD1 . ASP A  1 382 ? -0.21681  -2.00205  37.11535  1.000 18.77410 ? 381  ASP A OD1 1 
ATOM   3270 O OD2 . ASP A  1 382 ? 1.72548   -1.90120  38.11471  1.000 19.74376 ? 381  ASP A OD2 1 
ATOM   3271 N N   . ALA A  1 383 ? -2.27568  -3.28847  39.40544  1.000 16.92229 ? 382  ALA A N   1 
ATOM   3272 C CA  . ALA A  1 383 ? -3.50221  -2.56606  39.69769  1.000 16.91184 ? 382  ALA A CA  1 
ATOM   3273 C C   . ALA A  1 383 ? -3.64216  -1.31974  38.84363  1.000 17.08320 ? 382  ALA A C   1 
ATOM   3274 O O   . ALA A  1 383 ? -4.76889  -0.85562  38.63235  1.000 20.04781 ? 382  ALA A O   1 
ATOM   3275 C CB  . ALA A  1 383 ? -3.55242  -2.19670  41.18629  1.000 16.03074 ? 382  ALA A CB  1 
ATOM   3276 N N   A GLU A  1 384 ? -2.53443  -0.77191  38.33162  0.657 17.11206 ? 383  GLU A N   1 
ATOM   3277 N N   B GLU A  1 384 ? -2.52646  -0.77902  38.34468  0.343 17.21513 ? 383  GLU A N   1 
ATOM   3278 C CA  A GLU A  1 384 ? -2.61892  0.40920   37.47686  0.657 18.36248 ? 383  GLU A CA  1 
ATOM   3279 C CA  B GLU A  1 384 ? -2.55221  0.39963   37.48520  0.343 18.46040 ? 383  GLU A CA  1 
ATOM   3280 C C   A GLU A  1 384 ? -3.05224  0.04615   36.06425  0.657 19.08198 ? 383  GLU A C   1 
ATOM   3281 C C   B GLU A  1 384 ? -3.02902  0.05118   36.08131  0.343 19.09162 ? 383  GLU A C   1 
ATOM   3282 O O   A GLU A  1 384 ? -3.93237  0.69579   35.49369  0.657 18.38062 ? 383  GLU A O   1 
ATOM   3283 O O   B GLU A  1 384 ? -3.92178  0.71040   35.53952  0.343 18.41426 ? 383  GLU A O   1 
ATOM   3284 C CB  A GLU A  1 384 ? -1.27973  1.14026   37.43152  0.657 20.06324 ? 383  GLU A CB  1 
ATOM   3285 C CB  B GLU A  1 384 ? -1.16093  1.03122   37.42775  0.343 20.37075 ? 383  GLU A CB  1 
ATOM   3286 C CG  A GLU A  1 384 ? -0.93440  1.83283   38.74220  0.657 27.52375 ? 383  GLU A CG  1 
ATOM   3287 C CG  B GLU A  1 384 ? -0.83427  1.89298   38.63580  0.343 27.39475 ? 383  GLU A CG  1 
ATOM   3288 C CD  A GLU A  1 384 ? -2.03306  2.78274   39.20499  0.657 28.60335 ? 383  GLU A CD  1 
ATOM   3289 C CD  B GLU A  1 384 ? -1.72340  3.11464   38.72758  0.343 29.64609 ? 383  GLU A CD  1 
ATOM   3290 O OE1 A GLU A  1 384 ? -2.44313  3.65720   38.41206  0.657 27.70408 ? 383  GLU A OE1 1 
ATOM   3291 O OE1 B GLU A  1 384 ? -1.71235  3.91455   37.77158  0.343 33.91401 ? 383  GLU A OE1 1 
ATOM   3292 O OE2 A GLU A  1 384 ? -2.48293  2.64715   40.36243  0.657 34.85139 ? 383  GLU A OE2 1 
ATOM   3293 O OE2 B GLU A  1 384 ? -2.44373  3.26492   39.73676  0.343 27.12833 ? 383  GLU A OE2 1 
ATOM   3294 N N   . SER A  1 385 ? -2.43520  -0.97696  35.46984  1.000 17.72220 ? 384  SER A N   1 
ATOM   3295 C CA  . SER A  1 385 ? -2.89914  -1.39892  34.14685  1.000 15.42895 ? 384  SER A CA  1 
ATOM   3296 C C   . SER A  1 385 ? -4.34698  -1.86956  34.20808  1.000 18.05925 ? 384  SER A C   1 
ATOM   3297 O O   . SER A  1 385 ? -5.09728  -1.70782  33.23596  1.000 18.14731 ? 384  SER A O   1 
ATOM   3298 C CB  . SER A  1 385 ? -1.96758  -2.47858  33.58179  1.000 17.58818 ? 384  SER A CB  1 
ATOM   3299 O OG  . SER A  1 385 ? -2.10093  -3.70772  34.27514  1.000 17.86890 ? 384  SER A OG  1 
ATOM   3300 N N   . PHE A  1 386 ? -4.78102  -2.39759  35.35313  1.000 16.06185 ? 385  PHE A N   1 
ATOM   3301 C CA  . PHE A  1 386 ? -6.16317  -2.84547  35.46466  1.000 16.48383 ? 385  PHE A CA  1 
ATOM   3302 C C   . PHE A  1 386 ? -7.14582  -1.67565  35.51475  1.000 18.04331 ? 385  PHE A C   1 
ATOM   3303 O O   . PHE A  1 386 ? -8.33135  -1.87068  35.23409  1.000 18.47063 ? 385  PHE A O   1 
ATOM   3304 C CB  . PHE A  1 386 ? -6.35412  -3.74441  36.70355  1.000 13.64378 ? 385  PHE A CB  1 
ATOM   3305 C CG  . PHE A  1 386 ? -5.73030  -5.12192  36.56790  1.000 16.17448 ? 385  PHE A CG  1 
ATOM   3306 C CD1 . PHE A  1 386 ? -5.24564  -5.56144  35.33749  1.000 18.15573 ? 385  PHE A CD1 1 
ATOM   3307 C CD2 . PHE A  1 386 ? -5.62870  -5.96710  37.66866  1.000 18.62487 ? 385  PHE A CD2 1 
ATOM   3308 C CE1 . PHE A  1 386 ? -4.66590  -6.82141  35.20532  1.000 17.77926 ? 385  PHE A CE1 1 
ATOM   3309 C CE2 . PHE A  1 386 ? -5.03811  -7.22198  37.55052  1.000 18.15238 ? 385  PHE A CE2 1 
ATOM   3310 C CZ  . PHE A  1 386 ? -4.55862  -7.65616  36.30007  1.000 17.70706 ? 385  PHE A CZ  1 
ATOM   3311 N N   . LYS A  1 387 ? -6.69964  -0.47084  35.87471  1.000 17.18729 ? 386  LYS A N   1 
ATOM   3312 C CA  . LYS A  1 387 ? -7.58961  0.68482   35.77035  1.000 16.33085 ? 386  LYS A CA  1 
ATOM   3313 C C   . LYS A  1 387 ? -8.02032  0.90429   34.33260  1.000 18.01363 ? 386  LYS A C   1 
ATOM   3314 O O   . LYS A  1 387 ? -9.20690  1.09749   34.04575  1.000 19.63207 ? 386  LYS A O   1 
ATOM   3315 C CB  . LYS A  1 387 ? -6.90242  1.94448   36.30041  1.000 18.34136 ? 386  LYS A CB  1 
ATOM   3316 C CG  . LYS A  1 387 ? -6.66364  1.92040   37.80073  1.000 16.18169 ? 386  LYS A CG  1 
ATOM   3317 C CD  . LYS A  1 387 ? -5.97012  3.20257   38.26043  1.000 19.98589 ? 386  LYS A CD  1 
ATOM   3318 C CE  . LYS A  1 387 ? -5.87535  3.26562   39.78186  1.000 26.90711 ? 386  LYS A CE  1 
ATOM   3319 N NZ  . LYS A  1 387 ? -4.93906  4.35007   40.20591  1.000 27.26512 ? 386  LYS A NZ  1 
ATOM   3320 N N   . TYR A  1 388 ? -7.06141  0.87138   33.41236  1.000 16.38553 ? 387  TYR A N   1 
ATOM   3321 C CA  . TYR A  1 388 ? -7.37435  1.10584   32.00586  1.000 16.62247 ? 387  TYR A CA  1 
ATOM   3322 C C   . TYR A  1 388 ? -8.17010  -0.05088  31.42043  1.000 18.14951 ? 387  TYR A C   1 
ATOM   3323 O O   . TYR A  1 388 ? -9.12519  0.16459   30.66622  1.000 18.44735 ? 387  TYR A O   1 
ATOM   3324 C CB  . TYR A  1 388 ? -6.08294  1.35181   31.21861  1.000 19.55399 ? 387  TYR A CB  1 
ATOM   3325 C CG  . TYR A  1 388 ? -5.30033  2.49989   31.80772  1.000 20.27867 ? 387  TYR A CG  1 
ATOM   3326 C CD1 . TYR A  1 388 ? -5.52743  3.80690   31.38782  1.000 20.36397 ? 387  TYR A CD1 1 
ATOM   3327 C CD2 . TYR A  1 388 ? -4.36620  2.27994   32.81915  1.000 20.81795 ? 387  TYR A CD2 1 
ATOM   3328 C CE1 . TYR A  1 388 ? -4.82629  4.87153   31.95585  1.000 21.81096 ? 387  TYR A CE1 1 
ATOM   3329 C CE2 . TYR A  1 388 ? -3.66848  3.32911   33.39031  1.000 22.96807 ? 387  TYR A CE2 1 
ATOM   3330 C CZ  . TYR A  1 388 ? -3.90290  4.62104   32.95364  1.000 24.97430 ? 387  TYR A CZ  1 
ATOM   3331 O OH  . TYR A  1 388 ? -3.20120  5.66106   33.51737  1.000 26.40159 ? 387  TYR A OH  1 
ATOM   3332 N N   . LYS A  1 389 ? -7.81975  -1.28423  31.78693  1.000 17.94230 ? 388  LYS A N   1 
ATOM   3333 C CA  . LYS A  1 389 ? -8.56213  -2.42410  31.26774  1.000 17.32275 ? 388  LYS A CA  1 
ATOM   3334 C C   . LYS A  1 389 ? -9.97635  -2.46173  31.83420  1.000 20.03254 ? 388  LYS A C   1 
ATOM   3335 O O   . LYS A  1 389 ? -10.92269 -2.82186  31.12579  1.000 19.04684 ? 388  LYS A O   1 
ATOM   3336 C CB  . LYS A  1 389 ? -7.80219  -3.71505  31.56904  1.000 15.60461 ? 388  LYS A CB  1 
ATOM   3337 C CG  . LYS A  1 389 ? -6.60439  -3.85652  30.63510  1.000 16.82638 ? 388  LYS A CG  1 
ATOM   3338 C CD  . LYS A  1 389 ? -5.69028  -5.03317  30.95992  1.000 15.20443 ? 388  LYS A CD  1 
ATOM   3339 C CE  . LYS A  1 389 ? -4.52717  -5.06599  29.94165  1.000 17.09937 ? 388  LYS A CE  1 
ATOM   3340 N NZ  . LYS A  1 389 ? -3.56730  -6.21021  30.19450  1.000 16.90401 ? 388  LYS A NZ  1 
ATOM   3341 N N   . ALA A  1 390 ? -10.14780 -2.09179  33.10311  1.000 16.57439 ? 389  ALA A N   1 
ATOM   3342 C CA  . ALA A  1 390 ? -11.49818 -2.04612  33.65176  1.000 16.08437 ? 389  ALA A CA  1 
ATOM   3343 C C   . ALA A  1 390 ? -12.32631 -0.96456  32.97094  1.000 16.51129 ? 389  ALA A C   1 
ATOM   3344 O O   . ALA A  1 390 ? -13.50998 -1.17197  32.68584  1.000 20.26376 ? 389  ALA A O   1 
ATOM   3345 C CB  . ALA A  1 390 ? -11.45487 -1.81003  35.16624  1.000 16.90356 ? 389  ALA A CB  1 
ATOM   3346 N N   . LYS A  1 391 ? -11.72798 0.20225   32.71892  1.000 17.30942 ? 390  LYS A N   1 
ATOM   3347 C CA  . LYS A  1 391 ? -12.45907 1.25221   32.02096  1.000 18.93557 ? 390  LYS A CA  1 
ATOM   3348 C C   . LYS A  1 391 ? -12.83329 0.80301   30.61706  1.000 20.68725 ? 390  LYS A C   1 
ATOM   3349 O O   . LYS A  1 391 ? -13.94774 1.06429   30.15398  1.000 21.15786 ? 390  LYS A O   1 
ATOM   3350 C CB  . LYS A  1 391 ? -11.63812 2.53910   31.98326  1.000 21.59229 ? 390  LYS A CB  1 
ATOM   3351 C CG  . LYS A  1 391 ? -12.28513 3.65750   31.15097  1.000 20.41488 ? 390  LYS A CG  1 
ATOM   3352 C CD  . LYS A  1 391 ? -11.79099 5.04039   31.58299  1.000 23.19558 ? 390  LYS A CD  1 
ATOM   3353 C CE  . LYS A  1 391 ? -12.30574 6.13191   30.62940  1.000 24.62562 ? 390  LYS A CE  1 
ATOM   3354 N NZ  . LYS A  1 391 ? -12.10485 7.53260   31.17673  1.000 24.84308 ? 390  LYS A NZ  1 
ATOM   3355 N N   . TYR A  1 392 ? -11.92124 0.09887   29.93721  1.000 18.68233 ? 391  TYR A N   1 
ATOM   3356 C CA  . TYR A  1 392 ? -12.22406 -0.43608  28.61336  1.000 19.58683 ? 391  TYR A CA  1 
ATOM   3357 C C   . TYR A  1 392 ? -13.38868 -1.41875  28.67849  1.000 18.61101 ? 391  TYR A C   1 
ATOM   3358 O O   . TYR A  1 392 ? -14.30784 -1.36082  27.85009  1.000 20.63957 ? 391  TYR A O   1 
ATOM   3359 C CB  . TYR A  1 392 ? -10.96468 -1.09400  28.04099  1.000 17.37953 ? 391  TYR A CB  1 
ATOM   3360 C CG  . TYR A  1 392 ? -11.05163 -1.58195  26.60810  1.000 17.22006 ? 391  TYR A CG  1 
ATOM   3361 C CD1 . TYR A  1 392 ? -11.49328 -2.86654  26.32227  1.000 17.71595 ? 391  TYR A CD1 1 
ATOM   3362 C CD2 . TYR A  1 392 ? -10.67430 -0.76557  25.55125  1.000 18.81688 ? 391  TYR A CD2 1 
ATOM   3363 C CE1 . TYR A  1 392 ? -11.55601 -3.32850  25.02746  1.000 17.54312 ? 391  TYR A CE1 1 
ATOM   3364 C CE2 . TYR A  1 392 ? -10.73918 -1.21706  24.23989  1.000 18.02742 ? 391  TYR A CE2 1 
ATOM   3365 C CZ  . TYR A  1 392 ? -11.18679 -2.49807  23.98961  1.000 17.31982 ? 391  TYR A CZ  1 
ATOM   3366 O OH  . TYR A  1 392 ? -11.24020 -2.96819  22.70108  1.000 19.12762 ? 391  TYR A OH  1 
ATOM   3367 N N   . ILE A  1 393 ? -13.38025 -2.30763  29.67797  1.000 17.77744 ? 392  ILE A N   1 
ATOM   3368 C CA  . ILE A  1 393 ? -14.46962 -3.26503  29.85796  1.000 16.78707 ? 392  ILE A CA  1 
ATOM   3369 C C   . ILE A  1 393 ? -15.80591 -2.54177  29.98983  1.000 22.55383 ? 392  ILE A C   1 
ATOM   3370 O O   . ILE A  1 393 ? -16.81081 -2.94512  29.39581  1.000 20.71820 ? 392  ILE A O   1 
ATOM   3371 C CB  . ILE A  1 393 ? -14.18565 -4.15908  31.07737  1.000 17.22745 ? 392  ILE A CB  1 
ATOM   3372 C CG1 . ILE A  1 393 ? -13.08987 -5.17877  30.73620  1.000 17.16345 ? 392  ILE A CG1 1 
ATOM   3373 C CG2 . ILE A  1 393 ? -15.44626 -4.88759  31.53151  1.000 17.26543 ? 392  ILE A CG2 1 
ATOM   3374 C CD1 . ILE A  1 393 ? -12.47317 -5.81229  31.99204  1.000 15.77483 ? 392  ILE A CD1 1 
ATOM   3375 N N   A LYS A  1 394 ? -15.84291 -1.47223  30.78733  0.415 20.03734 ? 393  LYS A N   1 
ATOM   3376 N N   B LYS A  1 394 ? -15.83258 -1.44914  30.75295  0.585 20.04208 ? 393  LYS A N   1 
ATOM   3377 C CA  A LYS A  1 394 ? -17.07315 -0.69292  30.90705  0.415 21.11137 ? 393  LYS A CA  1 
ATOM   3378 C CA  B LYS A  1 394 ? -17.08152 -0.71353  30.92699  0.585 21.07560 ? 393  LYS A CA  1 
ATOM   3379 C C   A LYS A  1 394 ? -17.43584 -0.03050  29.58573  0.415 21.18676 ? 393  LYS A C   1 
ATOM   3380 C C   B LYS A  1 394 ? -17.46059 0.06408   29.66215  0.585 21.23276 ? 393  LYS A C   1 
ATOM   3381 O O   A LYS A  1 394 ? -18.56675 -0.15938  29.10213  0.415 24.10483 ? 393  LYS A O   1 
ATOM   3382 O O   B LYS A  1 394 ? -18.63271 0.07304   29.26913  0.585 23.79622 ? 393  LYS A O   1 
ATOM   3383 C CB  A LYS A  1 394 ? -16.92720 0.37220   31.99085  0.415 23.03448 ? 393  LYS A CB  1 
ATOM   3384 C CB  B LYS A  1 394 ? -16.96699 0.20144   32.15480  0.585 23.21351 ? 393  LYS A CB  1 
ATOM   3385 C CG  A LYS A  1 394 ? -16.63979 -0.15569  33.36324  0.415 24.67151 ? 393  LYS A CG  1 
ATOM   3386 C CG  B LYS A  1 394 ? -17.00329 -0.58006  33.48282  0.585 24.30152 ? 393  LYS A CG  1 
ATOM   3387 C CD  A LYS A  1 394 ? -16.36216 1.00634   34.29270  0.415 24.31886 ? 393  LYS A CD  1 
ATOM   3388 C CD  B LYS A  1 394 ? -16.73260 0.27910   34.73931  0.585 21.74436 ? 393  LYS A CD  1 
ATOM   3389 C CE  A LYS A  1 394 ? -15.33717 0.64527   35.33222  0.415 22.92367 ? 393  LYS A CE  1 
ATOM   3390 C CE  B LYS A  1 394 ? -15.47083 1.12083   34.60835  0.585 23.27095 ? 393  LYS A CE  1 
ATOM   3391 N NZ  A LYS A  1 394 ? -15.36992 1.61803   36.45911  0.415 18.39681 ? 393  LYS A NZ  1 
ATOM   3392 N NZ  B LYS A  1 394 ? -15.14796 1.86991   35.87726  0.585 18.99213 ? 393  LYS A NZ  1 
ATOM   3393 N N   . GLN A  1 395 ? -16.48815 0.70550   28.99964  1.000 21.38485 ? 394  GLN A N   1 
ATOM   3394 C CA  . GLN A  1 395 ? -16.78467 1.47603   27.79106  1.000 23.55766 ? 394  GLN A CA  1 
ATOM   3395 C C   . GLN A  1 395 ? -17.26821 0.58418   26.65892  1.000 30.35494 ? 394  GLN A C   1 
ATOM   3396 O O   . GLN A  1 395 ? -18.16816 0.96531   25.90134  1.000 25.76897 ? 394  GLN A O   1 
ATOM   3397 C CB  . GLN A  1 395 ? -15.55380 2.24711   27.31256  1.000 25.87921 ? 394  GLN A CB  1 
ATOM   3398 C CG  . GLN A  1 395 ? -15.08096 3.37315   28.21077  1.000 28.56132 ? 394  GLN A CG  1 
ATOM   3399 C CD  . GLN A  1 395 ? -13.83898 4.04760   27.63873  1.000 33.07222 ? 394  GLN A CD  1 
ATOM   3400 O OE1 . GLN A  1 395 ? -12.89238 3.37635   27.20645  1.000 37.35676 ? 394  GLN A OE1 1 
ATOM   3401 N NE2 . GLN A  1 395 ? -13.84481 5.36975   27.61301  1.000 38.60721 ? 394  GLN A NE2 1 
ATOM   3402 N N   . GLN A  1 396 ? -16.66390 -0.58836  26.50661  1.000 20.50333 ? 395  GLN A N   1 
ATOM   3403 C CA  . GLN A  1 396 ? -17.02938 -1.50918  25.43641  1.000 21.50663 ? 395  GLN A CA  1 
ATOM   3404 C C   . GLN A  1 396 ? -18.17440 -2.43663  25.82220  1.000 18.79884 ? 395  GLN A C   1 
ATOM   3405 O O   . GLN A  1 396 ? -18.55081 -3.30124  25.01859  1.000 20.26139 ? 395  GLN A O   1 
ATOM   3406 C CB  . GLN A  1 396 ? -15.80922 -2.33385  25.01907  1.000 19.54889 ? 395  GLN A CB  1 
ATOM   3407 C CG  . GLN A  1 396 ? -14.68113 -1.48626  24.45995  1.000 22.11994 ? 395  GLN A CG  1 
ATOM   3408 C CD  . GLN A  1 396 ? -15.04938 -0.87805  23.12268  1.000 30.32972 ? 395  GLN A CD  1 
ATOM   3409 O OE1 . GLN A  1 396 ? -15.61327 -1.55037  22.25580  1.000 27.48893 ? 395  GLN A OE1 1 
ATOM   3410 N NE2 . GLN A  1 396 ? -14.75527 0.40143   22.95724  1.000 33.76028 ? 395  GLN A NE2 1 
ATOM   3411 N N   . GLN A  1 397 ? -18.73263 -2.27033  27.02211  1.000 18.38665 ? 396  GLN A N   1 
ATOM   3412 C CA  . GLN A  1 397 ? -19.87243 -3.05458  27.50042  1.000 19.47033 ? 396  GLN A CA  1 
ATOM   3413 C C   . GLN A  1 397 ? -19.58256 -4.54994  27.45670  1.000 20.71249 ? 396  GLN A C   1 
ATOM   3414 O O   . GLN A  1 397 ? -20.42520 -5.35066  27.06244  1.000 18.41480 ? 396  GLN A O   1 
ATOM   3415 C CB  . GLN A  1 397 ? -21.14369 -2.71880  26.71353  1.000 24.72364 ? 396  GLN A CB  1 
ATOM   3416 C CG  . GLN A  1 397 ? -21.49637 -1.23915  26.79222  1.000 29.52503 ? 396  GLN A CG  1 
ATOM   3417 C CD  . GLN A  1 397 ? -22.77247 -0.90975  26.05086  1.000 42.94739 ? 396  GLN A CD  1 
ATOM   3418 O OE1 . GLN A  1 397 ? -22.73943 -0.32220  24.97354  1.000 44.60634 ? 396  GLN A OE1 1 
ATOM   3419 N NE2 . GLN A  1 397 ? -23.90464 -1.30045  26.61927  1.000 43.06195 ? 396  GLN A NE2 1 
ATOM   3420 N N   . LEU A  1 398 ? -18.38071 -4.92670  27.87869  1.000 19.75152 ? 397  LEU A N   1 
ATOM   3421 C CA  . LEU A  1 398 ? -18.00565 -6.32614  27.94110  1.000 17.64897 ? 397  LEU A CA  1 
ATOM   3422 C C   . LEU A  1 398 ? -18.60579 -6.98599  29.18093  1.000 18.32315 ? 397  LEU A C   1 
ATOM   3423 O O   . LEU A  1 398 ? -19.11673 -6.32428  30.09752  1.000 19.37840 ? 397  LEU A O   1 
ATOM   3424 C CB  . LEU A  1 398 ? -16.48295 -6.46002  27.93155  1.000 16.06347 ? 397  LEU A CB  1 
ATOM   3425 C CG  . LEU A  1 398 ? -15.77567 -5.71570  26.79084  1.000 14.79942 ? 397  LEU A CG  1 
ATOM   3426 C CD1 . LEU A  1 398 ? -14.26775 -5.98470  26.85728  1.000 18.50018 ? 397  LEU A CD1 1 
ATOM   3427 C CD2 . LEU A  1 398 ? -16.35899 -6.07169  25.41492  1.000 14.56638 ? 397  LEU A CD2 1 
ATOM   3428 N N   . GLY A  1 399 ? -18.54120 -8.31827  29.20292  1.000 15.94139 ? 398  GLY A N   1 
ATOM   3429 C CA  . GLY A  1 399 ? -19.14489 -9.06878  30.29052  1.000 15.99329 ? 398  GLY A CA  1 
ATOM   3430 C C   . GLY A  1 399 ? -18.37739 -8.99629  31.59367  1.000 17.37476 ? 398  GLY A C   1 
ATOM   3431 O O   . GLY A  1 399 ? -18.96105 -9.17498  32.66622  1.000 18.03709 ? 398  GLY A O   1 
ATOM   3432 N N   . GLY A  1 400 ? -17.08557 -8.74670  31.53124  1.000 16.68800 ? 399  GLY A N   1 
ATOM   3433 C CA  . GLY A  1 400 ? -16.31285 -8.73939  32.76827  1.000 15.79824 ? 399  GLY A CA  1 
ATOM   3434 C C   . GLY A  1 400 ? -14.85929 -9.09752  32.49238  1.000 16.76497 ? 399  GLY A C   1 
ATOM   3435 O O   . GLY A  1 400 ? -14.35275 -8.86170  31.40010  1.000 16.58659 ? 399  GLY A O   1 
ATOM   3436 N N   . VAL A  1 401 ? -14.22202 -9.67443  33.51504  1.000 15.66013 ? 400  VAL A N   1 
ATOM   3437 C CA  . VAL A  1 401 ? -12.79629 -9.97281  33.51250  1.000 14.32922 ? 400  VAL A CA  1 
ATOM   3438 C C   . VAL A  1 401 ? -12.58227 -11.41331 33.95437  1.000 15.00286 ? 400  VAL A C   1 
ATOM   3439 O O   . VAL A  1 401 ? -13.32909 -11.95117 34.78137  1.000 15.28999 ? 400  VAL A O   1 
ATOM   3440 C CB  . VAL A  1 401 ? -12.01743 -8.98494  34.42801  1.000 13.74098 ? 400  VAL A CB  1 
ATOM   3441 C CG1 . VAL A  1 401 ? -12.35124 -9.21204  35.91803  1.000 15.19095 ? 400  VAL A CG1 1 
ATOM   3442 C CG2 . VAL A  1 401 ? -10.50346 -9.07533  34.18343  1.000 16.48533 ? 400  VAL A CG2 1 
ATOM   3443 N N   A MET A  1 402 ? -11.55612 -12.04717 33.37834  0.610 14.68654 ? 401  MET A N   1 
ATOM   3444 N N   B MET A  1 402 ? -11.55633 -12.04042 33.38155  0.390 14.69449 ? 401  MET A N   1 
ATOM   3445 C CA  A MET A  1 402 ? -11.08632 -13.36815 33.77937  0.610 14.15049 ? 401  MET A CA  1 
ATOM   3446 C CA  B MET A  1 402 ? -11.08267 -13.35687 33.78033  0.390 14.16764 ? 401  MET A CA  1 
ATOM   3447 C C   A MET A  1 402 ? -9.59207  -13.26605 34.06189  0.610 13.58281 ? 401  MET A C   1 
ATOM   3448 C C   B MET A  1 402 ? -9.59788  -13.23161 34.09596  0.390 13.60278 ? 401  MET A C   1 
ATOM   3449 O O   A MET A  1 402 ? -8.89378  -12.46497 33.44157  0.610 14.59545 ? 401  MET A O   1 
ATOM   3450 O O   B MET A  1 402 ? -8.91295  -12.37421 33.53650  0.390 14.61715 ? 401  MET A O   1 
ATOM   3451 C CB  A MET A  1 402 ? -11.36009 -14.43243 32.66744  0.610 14.76900 ? 401  MET A CB  1 
ATOM   3452 C CB  B MET A  1 402 ? -11.33122 -14.39939 32.65277  0.390 14.73878 ? 401  MET A CB  1 
ATOM   3453 C CG  A MET A  1 402 ? -10.80126 -15.84259 32.95148  0.610 13.10200 ? 401  MET A CG  1 
ATOM   3454 C CG  B MET A  1 402 ? -10.62902 -15.74689 32.82691  0.390 13.41521 ? 401  MET A CG  1 
ATOM   3455 S SD  A MET A  1 402 ? -9.06389  -16.05943 32.47160  0.610 14.68778 ? 401  MET A SD  1 
ATOM   3456 S SD  B MET A  1 402 ? -8.92281  -15.71735 32.23086  0.390 14.24976 ? 401  MET A SD  1 
ATOM   3457 C CE  A MET A  1 402 ? -9.25093  -16.51449 30.73837  0.610 13.15082 ? 401  MET A CE  1 
ATOM   3458 C CE  B MET A  1 402 ? -9.19088  -15.87078 30.45900  0.390 12.28080 ? 401  MET A CE  1 
ATOM   3459 N N   . PHE A  1 403 ? -9.09060  -14.07993 34.99081  1.000 13.88345 ? 402  PHE A N   1 
ATOM   3460 C CA  . PHE A  1 403 ? -7.65138  -14.04420 35.24132  1.000 15.29439 ? 402  PHE A CA  1 
ATOM   3461 C C   . PHE A  1 403 ? -7.07684  -15.40381 35.60588  1.000 14.54047 ? 402  PHE A C   1 
ATOM   3462 O O   . PHE A  1 403 ? -7.73441  -16.23434 36.23344  1.000 14.06935 ? 402  PHE A O   1 
ATOM   3463 C CB  . PHE A  1 403 ? -7.28513  -13.00034 36.31381  1.000 14.71075 ? 402  PHE A CB  1 
ATOM   3464 C CG  . PHE A  1 403 ? -7.88634  -13.25167 37.67433  1.000 15.55352 ? 402  PHE A CG  1 
ATOM   3465 C CD1 . PHE A  1 403 ? -7.23144  -14.05355 38.60111  1.000 15.61346 ? 402  PHE A CD1 1 
ATOM   3466 C CD2 . PHE A  1 403 ? -9.06962  -12.62746 38.04272  1.000 16.13919 ? 402  PHE A CD2 1 
ATOM   3467 C CE1 . PHE A  1 403 ? -7.76854  -14.26691 39.87572  1.000 16.33490 ? 402  PHE A CE1 1 
ATOM   3468 C CE2 . PHE A  1 403 ? -9.61622  -12.82686 39.31030  1.000 17.43317 ? 402  PHE A CE2 1 
ATOM   3469 C CZ  . PHE A  1 403 ? -8.96541  -13.64756 40.22447  1.000 17.90130 ? 402  PHE A CZ  1 
ATOM   3470 N N   . TRP A  1 404 ? -5.82102  -15.60240 35.19185  1.000 14.08132 ? 403  TRP A N   1 
ATOM   3471 C CA  . TRP A  1 404 ? -4.99415  -16.75676 35.53712  1.000 14.34886 ? 403  TRP A CA  1 
ATOM   3472 C C   . TRP A  1 404 ? -3.79971  -16.24841 36.33970  1.000 14.10112 ? 403  TRP A C   1 
ATOM   3473 O O   . TRP A  1 404 ? -3.04796  -15.41576 35.82649  1.000 14.84907 ? 403  TRP A O   1 
ATOM   3474 C CB  . TRP A  1 404 ? -4.49052  -17.44341 34.25386  1.000 15.04870 ? 403  TRP A CB  1 
ATOM   3475 C CG  . TRP A  1 404 ? -3.53017  -18.56196 34.54500  1.000 16.69210 ? 403  TRP A CG  1 
ATOM   3476 C CD1 . TRP A  1 404 ? -2.17740  -18.46266 34.76473  1.000 17.65153 ? 403  TRP A CD1 1 
ATOM   3477 C CD2 . TRP A  1 404 ? -3.86152  -19.93964 34.69183  1.000 15.04564 ? 403  TRP A CD2 1 
ATOM   3478 N NE1 . TRP A  1 404 ? -1.65284  -19.70691 35.03508  1.000 16.51293 ? 403  TRP A NE1 1 
ATOM   3479 C CE2 . TRP A  1 404 ? -2.66463  -20.62970 35.00939  1.000 15.72516 ? 403  TRP A CE2 1 
ATOM   3480 C CE3 . TRP A  1 404 ? -5.05696  -20.66756 34.58287  1.000 17.41335 ? 403  TRP A CE3 1 
ATOM   3481 C CZ2 . TRP A  1 404 ? -2.62528  -22.01618 35.20569  1.000 17.79651 ? 403  TRP A CZ2 1 
ATOM   3482 C CZ3 . TRP A  1 404 ? -5.02080  -22.05207 34.80972  1.000 19.00665 ? 403  TRP A CZ3 1 
ATOM   3483 C CH2 . TRP A  1 404 ? -3.81223  -22.70634 35.10985  1.000 17.48838 ? 403  TRP A CH2 1 
ATOM   3484 N N   . HIS A  1 405 ? -3.61003  -16.72468 37.58719  1.000 13.90248 ? 404  HIS A N   1 
ATOM   3485 C CA  . HIS A  1 405 ? -4.57606  -17.47937 38.38796  1.000 14.91618 ? 404  HIS A CA  1 
ATOM   3486 C C   . HIS A  1 405 ? -4.53903  -16.97080 39.83290  1.000 18.14418 ? 404  HIS A C   1 
ATOM   3487 O O   . HIS A  1 405 ? -3.69096  -16.14230 40.18877  1.000 16.39877 ? 404  HIS A O   1 
ATOM   3488 C CB  . HIS A  1 405 ? -4.32388  -19.01064 38.34520  1.000 16.16533 ? 404  HIS A CB  1 
ATOM   3489 C CG  . HIS A  1 405 ? -3.04223  -19.47548 38.98343  1.000 16.76483 ? 404  HIS A CG  1 
ATOM   3490 N ND1 . HIS A  1 405 ? -2.90769  -19.68732 40.34431  1.000 18.81861 ? 404  HIS A ND1 1 
ATOM   3491 C CD2 . HIS A  1 405 ? -1.85735  -19.83574 38.43041  1.000 15.66549 ? 404  HIS A CD2 1 
ATOM   3492 C CE1 . HIS A  1 405 ? -1.68459  -20.12119 40.60279  1.000 19.52859 ? 404  HIS A CE1 1 
ATOM   3493 N NE2 . HIS A  1 405 ? -1.03138  -20.23381 39.45471  1.000 18.54261 ? 404  HIS A NE2 1 
ATOM   3494 N N   . LEU A  1 406 ? -5.47326  -17.46319 40.65102  1.000 14.16346 ? 405  LEU A N   1 
ATOM   3495 C CA  . LEU A  1 406 ? -5.68845  -16.89634 41.98615  1.000 15.68593 ? 405  LEU A CA  1 
ATOM   3496 C C   . LEU A  1 406 ? -4.43935  -16.97220 42.85458  1.000 19.06808 ? 405  LEU A C   1 
ATOM   3497 O O   . LEU A  1 406 ? -4.17830  -16.06515 43.65897  1.000 17.06747 ? 405  LEU A O   1 
ATOM   3498 C CB  . LEU A  1 406 ? -6.84143  -17.61828 42.67701  1.000 15.89379 ? 405  LEU A CB  1 
ATOM   3499 C CG  . LEU A  1 406 ? -8.23595  -17.12550 42.28216  1.000 18.25882 ? 405  LEU A CG  1 
ATOM   3500 C CD1 . LEU A  1 406 ? -9.26622  -18.21940 42.54287  1.000 17.44885 ? 405  LEU A CD1 1 
ATOM   3501 C CD2 . LEU A  1 406 ? -8.59073  -15.83492 43.05080  1.000 16.76257 ? 405  LEU A CD2 1 
ATOM   3502 N N   . GLY A  1 407 ? -3.65587  -18.03884 42.71379  1.000 17.06881 ? 406  GLY A N   1 
ATOM   3503 C CA  . GLY A  1 407 ? -2.47104  -18.16887 43.55219  1.000 19.19615 ? 406  GLY A CA  1 
ATOM   3504 C C   . GLY A  1 407 ? -1.38519  -17.15087 43.26187  1.000 23.51465 ? 406  GLY A C   1 
ATOM   3505 O O   . GLY A  1 407 ? -0.45554  -17.01076 44.06649  1.000 19.59457 ? 406  GLY A O   1 
ATOM   3506 N N   . GLN A  1 408 ? -1.49534  -16.41775 42.15605  1.000 15.60781 ? 407  GLN A N   1 
ATOM   3507 C CA  . GLN A  1 408 ? -0.47392  -15.46362 41.76118  1.000 14.39130 ? 407  GLN A CA  1 
ATOM   3508 C C   . GLN A  1 408 ? -0.77442  -14.03913 42.20789  1.000 15.26398 ? 407  GLN A C   1 
ATOM   3509 O O   . GLN A  1 408 ? 0.11643   -13.18882 42.13257  1.000 16.68552 ? 407  GLN A O   1 
ATOM   3510 C CB  . GLN A  1 408 ? -0.28637  -15.50681 40.23091  1.000 12.54691 ? 407  GLN A CB  1 
ATOM   3511 C CG  . GLN A  1 408 ? 0.27585   -16.85187 39.79226  1.000 13.77094 ? 407  GLN A CG  1 
ATOM   3512 C CD  . GLN A  1 408 ? 0.21441   -17.06789 38.29201  1.000 18.29946 ? 407  GLN A CD  1 
ATOM   3513 O OE1 . GLN A  1 408 ? -0.70489  -16.59184 37.62122  1.000 17.02698 ? 407  GLN A OE1 1 
ATOM   3514 N NE2 . GLN A  1 408 ? 1.19759   -17.79549 37.75615  1.000 17.81293 ? 407  GLN A NE2 1 
ATOM   3515 N N   . ASP A  1 409 ? -2.00151  -13.75066 42.65045  1.000 18.28435 ? 408  ASP A N   1 
ATOM   3516 C CA  . ASP A  1 409 ? -2.25514  -12.51000 43.36770  1.000 15.67599 ? 408  ASP A CA  1 
ATOM   3517 C C   . ASP A  1 409 ? -1.39160  -12.48172 44.62445  1.000 16.25721 ? 408  ASP A C   1 
ATOM   3518 O O   . ASP A  1 409 ? -0.94835  -13.52395 45.12322  1.000 17.29927 ? 408  ASP A O   1 
ATOM   3519 C CB  . ASP A  1 409 ? -3.73500  -12.40001 43.74720  1.000 16.97224 ? 408  ASP A CB  1 
ATOM   3520 C CG  . ASP A  1 409 ? -4.21792  -10.95702 43.88652  1.000 16.53007 ? 408  ASP A CG  1 
ATOM   3521 O OD1 . ASP A  1 409 ? -3.38624  -10.01814 43.94736  1.000 15.83357 ? 408  ASP A OD1 1 
ATOM   3522 O OD2 . ASP A  1 409 ? -5.46009  -10.76729 43.93395  1.000 16.83833 ? 408  ASP A OD2 1 
ATOM   3523 N N   . ASN A  1 410 ? -1.14648  -11.27917 45.14031  1.000 16.79865 ? 409  ASN A N   1 
ATOM   3524 C CA  . ASN A  1 410 ? -0.36681  -11.23311 46.36982  1.000 15.60533 ? 409  ASN A CA  1 
ATOM   3525 C C   . ASN A  1 410 ? -1.20722  -11.73141 47.54868  1.000 18.99195 ? 409  ASN A C   1 
ATOM   3526 O O   . ASN A  1 410 ? -2.39536  -12.04683 47.42784  1.000 17.99236 ? 409  ASN A O   1 
ATOM   3527 C CB  . ASN A  1 410 ? 0.22909   -9.83277  46.59236  1.000 14.89385 ? 409  ASN A CB  1 
ATOM   3528 C CG  . ASN A  1 410 ? -0.80506  -8.74982  46.89109  1.000 18.53848 ? 409  ASN A CG  1 
ATOM   3529 O OD1 . ASN A  1 410 ? -1.98336  -9.01743  47.13788  1.000 18.54127 ? 409  ASN A OD1 1 
ATOM   3530 N ND2 . ASN A  1 410 ? -0.34446  -7.49410  46.86901  1.000 16.93248 ? 409  ASN A ND2 1 
ATOM   3531 N N   A ARG A  1 411 ? -0.55316  -11.81008 48.70933  0.308 18.75676 ? 410  ARG A N   1 
ATOM   3532 N N   B ARG A  1 411 ? -0.54954  -11.83011 48.70246  0.692 18.68803 ? 410  ARG A N   1 
ATOM   3533 C CA  A ARG A  1 411 ? -1.17277  -12.39607 49.89321  0.308 19.50614 ? 410  ARG A CA  1 
ATOM   3534 C CA  B ARG A  1 411 ? -1.18308  -12.40246 49.88460  0.692 19.41566 ? 410  ARG A CA  1 
ATOM   3535 C C   A ARG A  1 411 ? -2.46980  -11.68747 50.26264  0.308 18.78846 ? 410  ARG A C   1 
ATOM   3536 C C   B ARG A  1 411 ? -2.48326  -11.68892 50.23869  0.692 18.61552 ? 410  ARG A C   1 
ATOM   3537 O O   A ARG A  1 411 ? -3.43817  -12.32866 50.68868  0.308 22.09248 ? 410  ARG A O   1 
ATOM   3538 O O   B ARG A  1 411 ? -3.46723  -12.32948 50.63060  0.692 22.12161 ? 410  ARG A O   1 
ATOM   3539 C CB  A ARG A  1 411 ? -0.18379  -12.34718 51.05463  0.308 19.86461 ? 410  ARG A CB  1 
ATOM   3540 C CB  B ARG A  1 411 ? -0.20137  -12.34618 51.04885  0.692 19.74784 ? 410  ARG A CB  1 
ATOM   3541 C CG  A ARG A  1 411 ? -0.52083  -13.27211 52.18928  0.308 25.75261 ? 410  ARG A CG  1 
ATOM   3542 C CG  B ARG A  1 411 ? -0.75337  -12.92091 52.30210  0.692 24.25793 ? 410  ARG A CG  1 
ATOM   3543 C CD  A ARG A  1 411 ? 0.74661   -13.86479 52.77845  0.308 24.17061 ? 410  ARG A CD  1 
ATOM   3544 C CD  B ARG A  1 411 ? 0.37572   -13.26131 53.25920  0.692 19.60260 ? 410  ARG A CD  1 
ATOM   3545 N NE  A ARG A  1 411 ? 0.44522   -14.68548 53.94084  0.308 26.29145 ? 410  ARG A NE  1 
ATOM   3546 N NE  B ARG A  1 411 ? -0.18758  -13.82791 54.47049  0.692 26.24407 ? 410  ARG A NE  1 
ATOM   3547 C CZ  A ARG A  1 411 ? 1.08508   -14.60283 55.09709  0.308 26.88583 ? 410  ARG A CZ  1 
ATOM   3548 C CZ  B ARG A  1 411 ? 0.47423   -13.96001 55.60717  0.692 28.13173 ? 410  ARG A CZ  1 
ATOM   3549 N NH1 A ARG A  1 411 ? 2.09195   -13.76172 55.26965  0.308 21.01235 ? 410  ARG A NH1 1 
ATOM   3550 N NH1 B ARG A  1 411 ? 1.73564   -13.57388 55.71874  0.692 24.14797 ? 410  ARG A NH1 1 
ATOM   3551 N NH2 A ARG A  1 411 ? 0.70721   -15.38587 56.10351  0.308 27.10202 ? 410  ARG A NH2 1 
ATOM   3552 N NH2 B ARG A  1 411 ? -0.14815  -14.48529 56.65778  0.692 25.88242 ? 410  ARG A NH2 1 
ATOM   3553 N N   . ASN A  1 412 ? -2.51175  -10.36968 50.10235  1.000 17.96274 ? 411  ASN A N   1 
ATOM   3554 C CA  . ASN A  1 412 ? -3.69000  -9.59892  50.46827  1.000 23.09861 ? 411  ASN A CA  1 
ATOM   3555 C C   . ASN A  1 412 ? -4.74794  -9.57511  49.37424  1.000 23.11021 ? 411  ASN A C   1 
ATOM   3556 O O   . ASN A  1 412 ? -5.79878  -8.95212  49.56834  1.000 20.27070 ? 411  ASN A O   1 
ATOM   3557 C CB  . ASN A  1 412 ? -3.28003  -8.17375  50.81756  1.000 21.47632 ? 411  ASN A CB  1 
ATOM   3558 C CG  . ASN A  1 412 ? -2.62437  -8.09193  52.18986  1.000 24.20949 ? 411  ASN A CG  1 
ATOM   3559 O OD1 . ASN A  1 412 ? -2.71603  -9.03381  52.97722  1.000 27.31404 ? 411  ASN A OD1 1 
ATOM   3560 N ND2 . ASN A  1 412 ? -1.95391  -6.98489  52.46943  1.000 31.51445 ? 411  ASN A ND2 1 
ATOM   3561 N N   . GLY A  1 413 ? -4.49912  -10.22403 48.23955  1.000 20.29500 ? 412  GLY A N   1 
ATOM   3562 C CA  . GLY A  1 413 ? -5.47324  -10.20231 47.16339  1.000 19.38120 ? 412  GLY A CA  1 
ATOM   3563 C C   . GLY A  1 413 ? -5.65510  -8.85131  46.50992  1.000 18.73723 ? 412  GLY A C   1 
ATOM   3564 O O   . GLY A  1 413 ? -6.77208  -8.52060  46.08887  1.000 16.58719 ? 412  GLY A O   1 
ATOM   3565 N N   . ASP A  1 414 ? -4.58377  -8.05974  46.39868  1.000 16.10243 ? 413  ASP A N   1 
ATOM   3566 C CA  . ASP A  1 414 ? -4.72821  -6.68030  45.93743  1.000 16.90936 ? 413  ASP A CA  1 
ATOM   3567 C C   . ASP A  1 414 ? -5.19753  -6.58700  44.48370  1.000 17.22976 ? 413  ASP A C   1 
ATOM   3568 O O   . ASP A  1 414 ? -5.92025  -5.64893  44.13590  1.000 18.49214 ? 413  ASP A O   1 
ATOM   3569 C CB  . ASP A  1 414 ? -3.41564  -5.92697  46.09887  1.000 21.67631 ? 413  ASP A CB  1 
ATOM   3570 C CG  . ASP A  1 414 ? -3.09887  -5.61620  47.55350  1.000 22.95016 ? 413  ASP A CG  1 
ATOM   3571 O OD1 . ASP A  1 414 ? -4.01550  -5.67650  48.40197  1.000 23.70435 ? 413  ASP A OD1 1 
ATOM   3572 O OD2 . ASP A  1 414 ? -1.92400  -5.32084  47.83936  1.000 19.56327 ? 413  ASP A OD2 1 
ATOM   3573 N N   . LEU A  1 415 ? -4.76244  -7.50139  43.60613  1.000 15.20961 ? 414  LEU A N   1 
ATOM   3574 C CA  . LEU A  1 415 ? -5.19466  -7.40018  42.21182  1.000 16.31561 ? 414  LEU A CA  1 
ATOM   3575 C C   . LEU A  1 415 ? -6.69060  -7.67320  42.08372  1.000 15.05046 ? 414  LEU A C   1 
ATOM   3576 O O   . LEU A  1 415 ? -7.40786  -6.94448  41.38985  1.000 17.73704 ? 414  LEU A O   1 
ATOM   3577 C CB  . LEU A  1 415 ? -4.39813  -8.36457  41.32717  1.000 15.58212 ? 414  LEU A CB  1 
ATOM   3578 C CG  . LEU A  1 415 ? -2.90574  -8.07343  41.16175  1.000 16.31143 ? 414  LEU A CG  1 
ATOM   3579 C CD1 . LEU A  1 415 ? -2.31452  -9.02193  40.10323  1.000 13.87053 ? 414  LEU A CD1 1 
ATOM   3580 C CD2 . LEU A  1 415 ? -2.63323  -6.62331  40.77502  1.000 16.48748 ? 414  LEU A CD2 1 
ATOM   3581 N N   . LEU A  1 416 ? -7.17552  -8.72685  42.74363  1.000 17.64249 ? 415  LEU A N   1 
ATOM   3582 C CA  . LEU A  1 416 ? -8.60405  -9.01822  42.73725  1.000 17.29217 ? 415  LEU A CA  1 
ATOM   3583 C C   . LEU A  1 416 ? -9.40055  -7.88126  43.36921  1.000 19.54352 ? 415  LEU A C   1 
ATOM   3584 O O   . LEU A  1 416 ? -10.45187 -7.47997  42.84755  1.000 18.90883 ? 415  LEU A O   1 
ATOM   3585 C CB  . LEU A  1 416 ? -8.85944  -10.33470 43.47009  1.000 16.32712 ? 415  LEU A CB  1 
ATOM   3586 C CG  . LEU A  1 416 ? -10.31183 -10.67585 43.78967  1.000 16.17712 ? 415  LEU A CG  1 
ATOM   3587 C CD1 . LEU A  1 416 ? -11.11676 -10.75682 42.49333  1.000 16.53700 ? 415  LEU A CD1 1 
ATOM   3588 C CD2 . LEU A  1 416 ? -10.39705 -11.99032 44.54444  1.000 18.27222 ? 415  LEU A CD2 1 
ATOM   3589 N N   . ALA A  1 417 ? -8.90536  -7.33865  44.48603  1.000 17.21063 ? 416  ALA A N   1 
ATOM   3590 C CA  . ALA A  1 417 ? -9.59867  -6.23063  45.13848  1.000 18.22109 ? 416  ALA A CA  1 
ATOM   3591 C C   . ALA A  1 417 ? -9.64904  -5.00804  44.23322  1.000 18.13295 ? 416  ALA A C   1 
ATOM   3592 O O   . ALA A  1 417 ? -10.65045 -4.28314  44.21651  1.000 21.25865 ? 416  ALA A O   1 
ATOM   3593 C CB  . ALA A  1 417 ? -8.91968  -5.88755  46.47391  1.000 18.38483 ? 416  ALA A CB  1 
ATOM   3594 N N   . ALA A  1 418 ? -8.58812  -4.77327  43.45294  1.000 17.87191 ? 417  ALA A N   1 
ATOM   3595 C CA  . ALA A  1 418 ? -8.58190  -3.64167  42.52964  1.000 19.61113 ? 417  ALA A CA  1 
ATOM   3596 C C   . ALA A  1 418 ? -9.65246  -3.80641  41.46055  1.000 20.32897 ? 417  ALA A C   1 
ATOM   3597 O O   . ALA A  1 418 ? -10.42366 -2.87821  41.19153  1.000 19.60158 ? 417  ALA A O   1 
ATOM   3598 C CB  . ALA A  1 418 ? -7.20339  -3.48660  41.88369  1.000 18.35972 ? 417  ALA A CB  1 
ATOM   3599 N N   . LEU A  1 419 ? -9.72188  -4.99202  40.84321  1.000 17.31702 ? 418  LEU A N   1 
ATOM   3600 C CA  . LEU A  1 419 ? -10.73639 -5.22695  39.81625  1.000 20.06492 ? 418  LEU A CA  1 
ATOM   3601 C C   . LEU A  1 419 ? -12.13636 -5.03582  40.38387  1.000 18.44939 ? 418  LEU A C   1 
ATOM   3602 O O   . LEU A  1 419 ? -12.96784 -4.33728  39.79407  1.000 21.00533 ? 418  LEU A O   1 
ATOM   3603 C CB  . LEU A  1 419 ? -10.57759 -6.62971  39.23579  1.000 18.05419 ? 418  LEU A CB  1 
ATOM   3604 C CG  . LEU A  1 419 ? -9.31516  -6.78769  38.37656  1.000 17.75751 ? 418  LEU A CG  1 
ATOM   3605 C CD1 . LEU A  1 419 ? -9.05651  -8.27130  38.14588  1.000 20.98958 ? 418  LEU A CD1 1 
ATOM   3606 C CD2 . LEU A  1 419 ? -9.44908  -6.03999  37.04547  1.000 15.80586 ? 418  LEU A CD2 1 
ATOM   3607 N N   . ASP A  1 420 ? -12.40151 -5.62924  41.54741  1.000 18.07401 ? 419  ASP A N   1 
ATOM   3608 C CA  . ASP A  1 420 ? -13.68986 -5.43770  42.20285  1.000 19.13235 ? 419  ASP A CA  1 
ATOM   3609 C C   . ASP A  1 420 ? -13.96875 -3.95834  42.46144  1.000 18.47528 ? 419  ASP A C   1 
ATOM   3610 O O   . ASP A  1 420 ? -15.08616 -3.48247  42.23157  1.000 21.21294 ? 419  ASP A O   1 
ATOM   3611 C CB  . ASP A  1 420 ? -13.73237 -6.22809  43.50476  1.000 18.47104 ? 419  ASP A CB  1 
ATOM   3612 C CG  . ASP A  1 420 ? -14.99234 -5.96103  44.28541  1.000 23.10535 ? 419  ASP A CG  1 
ATOM   3613 O OD1 . ASP A  1 420 ? -16.06365 -6.36506  43.79963  1.000 19.76903 ? 419  ASP A OD1 1 
ATOM   3614 O OD2 . ASP A  1 420 ? -14.91143 -5.32799  45.36306  1.000 21.87187 ? 419  ASP A OD2 1 
ATOM   3615 N N   . ARG A  1 421 ? -12.95899 -3.20913  42.90858  1.000 18.94722 ? 420  ARG A N   1 
ATOM   3616 C CA  . ARG A  1 421 ? -13.15507 -1.78185  43.15676  1.000 20.53027 ? 420  ARG A CA  1 
ATOM   3617 C C   . ARG A  1 421 ? -13.50781 -1.03890  41.87018  1.000 22.29505 ? 420  ARG A C   1 
ATOM   3618 O O   . ARG A  1 421 ? -14.44589 -0.23287  41.83706  1.000 21.06296 ? 420  ARG A O   1 
ATOM   3619 C CB  . ARG A  1 421 ? -11.90197 -1.18241  43.79975  1.000 23.23307 ? 420  ARG A CB  1 
ATOM   3620 C CG  . ARG A  1 421 ? -11.90981 0.35027   43.88279  1.000 23.28627 ? 420  ARG A CG  1 
ATOM   3621 C CD  . ARG A  1 421 ? -10.68423 0.87512   44.64572  1.000 26.93683 ? 420  ARG A CD  1 
ATOM   3622 N NE  . ARG A  1 421 ? -10.60283 2.33428   44.63941  1.000 30.54790 ? 420  ARG A NE  1 
ATOM   3623 C CZ  . ARG A  1 421 ? -11.43232 3.14425   45.28705  1.000 39.23461 ? 420  ARG A CZ  1 
ATOM   3624 N NH1 . ARG A  1 421 ? -12.38684 2.67440   46.07737  1.000 31.61713 ? 420  ARG A NH1 1 
ATOM   3625 N NH2 . ARG A  1 421 ? -11.29415 4.46142   45.14502  1.000 37.77658 ? 420  ARG A NH2 1 
ATOM   3626 N N   . TYR A  1 422 ? -12.76947 -1.29853  40.78950  1.000 18.09242 ? 421  TYR A N   1 
ATOM   3627 C CA  . TYR A  1 422 ? -12.98959 -0.53080  39.56981  1.000 19.70557 ? 421  TYR A CA  1 
ATOM   3628 C C   . TYR A  1 422 ? -14.37608 -0.78008  38.99409  1.000 21.18988 ? 421  TYR A C   1 
ATOM   3629 O O   . TYR A  1 422 ? -14.93230 0.09782   38.33025  1.000 22.41738 ? 421  TYR A O   1 
ATOM   3630 C CB  . TYR A  1 422 ? -11.91465 -0.86147  38.53155  1.000 17.63627 ? 421  TYR A CB  1 
ATOM   3631 C CG  . TYR A  1 422 ? -10.50796 -0.65251  39.03764  1.000 17.42676 ? 421  TYR A CG  1 
ATOM   3632 C CD1 . TYR A  1 422 ? -10.24825 0.23055   40.08816  1.000 18.38378 ? 421  TYR A CD1 1 
ATOM   3633 C CD2 . TYR A  1 422 ? -9.43858  -1.34908  38.49002  1.000 16.30530 ? 421  TYR A CD2 1 
ATOM   3634 C CE1 . TYR A  1 422 ? -8.96607  0.40097   40.58090  1.000 21.89992 ? 421  TYR A CE1 1 
ATOM   3635 C CE2 . TYR A  1 422 ? -8.14038  -1.16831  38.96770  1.000 20.06394 ? 421  TYR A CE2 1 
ATOM   3636 C CZ  . TYR A  1 422 ? -7.91395  -0.29807  40.01577  1.000 21.76510 ? 421  TYR A CZ  1 
ATOM   3637 O OH  . TYR A  1 422 ? -6.63621  -0.10941  40.51363  1.000 20.11030 ? 421  TYR A OH  1 
ATOM   3638 N N   . PHE A  1 423 ? -14.95879 -1.94649  39.26021  1.000 20.28772 ? 422  PHE A N   1 
ATOM   3639 C CA  . PHE A  1 423 ? -16.29482 -2.26005  38.76861  1.000 21.54368 ? 422  PHE A CA  1 
ATOM   3640 C C   . PHE A  1 423 ? -17.39460 -1.81507  39.72299  1.000 22.28577 ? 422  PHE A C   1 
ATOM   3641 O O   . PHE A  1 423 ? -18.46031 -1.38217  39.26692  1.000 22.55287 ? 422  PHE A O   1 
ATOM   3642 C CB  . PHE A  1 423 ? -16.43524 -3.76454  38.53824  1.000 19.35625 ? 422  PHE A CB  1 
ATOM   3643 C CG  . PHE A  1 423 ? -15.60035 -4.27724  37.40191  1.000 20.44365 ? 422  PHE A CG  1 
ATOM   3644 C CD1 . PHE A  1 423 ? -15.42370 -3.51640  36.25733  1.000 21.29960 ? 422  PHE A CD1 1 
ATOM   3645 C CD2 . PHE A  1 423 ? -14.97006 -5.50430  37.49919  1.000 21.93132 ? 422  PHE A CD2 1 
ATOM   3646 C CE1 . PHE A  1 423 ? -14.64152 -3.97838  35.20517  1.000 21.65482 ? 422  PHE A CE1 1 
ATOM   3647 C CE2 . PHE A  1 423 ? -14.18822 -5.97238  36.46183  1.000 22.22282 ? 422  PHE A CE2 1 
ATOM   3648 C CZ  . PHE A  1 423 ? -14.02316 -5.20570  35.31178  1.000 23.51953 ? 422  PHE A CZ  1 
ATOM   3649 N N   . ASN A  1 424 ? -17.15792 -1.91583  41.03782  1.000 23.17627 ? 423  ASN A N   1 
ATOM   3650 C CA  . ASN A  1 424 ? -18.24487 -1.90141  42.00856  1.000 21.30195 ? 423  ASN A CA  1 
ATOM   3651 C C   . ASN A  1 424 ? -18.15085 -0.84973  43.10003  1.000 24.35589 ? 423  ASN A C   1 
ATOM   3652 O O   . ASN A  1 424 ? -19.15794 -0.61924  43.77951  1.000 25.13592 ? 423  ASN A O   1 
ATOM   3653 C CB  . ASN A  1 424 ? -18.36945 -3.27586  42.67719  1.000 20.43562 ? 423  ASN A CB  1 
ATOM   3654 C CG  . ASN A  1 424 ? -18.67678 -4.35367  41.67000  1.000 25.07228 ? 423  ASN A CG  1 
ATOM   3655 O OD1 . ASN A  1 424 ? -19.64114 -4.22823  40.91998  1.000 22.78827 ? 423  ASN A OD1 1 
ATOM   3656 N ND2 . ASN A  1 424 ? -17.85925 -5.40250  41.62843  1.000 21.22971 ? 423  ASN A ND2 1 
ATOM   3657 N N   . ALA A  1 425 ? -17.00451 -0.21608  43.29947  1.000 20.69936 ? 424  ALA A N   1 
ATOM   3658 C CA  . ALA A  1 425 ? -16.88845 0.73132   44.40464  1.000 23.17612 ? 424  ALA A CA  1 
ATOM   3659 C C   . ALA A  1 425 ? -17.60737 2.03435   44.05977  1.000 26.80380 ? 424  ALA A C   1 
ATOM   3660 O O   . ALA A  1 425 ? -17.36677 2.62976   43.00984  1.000 24.35846 ? 424  ALA A O   1 
ATOM   3661 C CB  . ALA A  1 425 ? -15.42030 0.99408   44.72832  1.000 22.31236 ? 424  ALA A CB  1 
ATOM   3662 N N   . ALA A  1 426 ? -18.48984 2.48484   44.96033  1.000 29.81646 ? 425  ALA A N   1 
ATOM   3663 C CA  . ALA A  1 426 ? -19.26541 3.69145   44.68851  1.000 31.62300 ? 425  ALA A CA  1 
ATOM   3664 C C   . ALA A  1 426 ? -18.38627 4.93424   44.63686  1.000 29.01314 ? 425  ALA A C   1 
ATOM   3665 O O   . ALA A  1 426 ? -18.70314 5.88504   43.91223  1.000 38.88846 ? 425  ALA A O   1 
ATOM   3666 C CB  . ALA A  1 426 ? -20.36141 3.86298   45.74539  1.000 37.70179 ? 425  ALA A CB  1 
ATOM   3667 N N   A ASP A  1 427 ? -17.27799 4.93801   45.37674  0.536 28.48093 ? 426  ASP A N   1 
ATOM   3668 N N   B ASP A  1 427 ? -17.28268 4.95281   45.38144  0.464 28.52305 ? 426  ASP A N   1 
ATOM   3669 C CA  A ASP A  1 427 ? -16.39773 6.09296   45.46420  0.536 31.25096 ? 426  ASP A CA  1 
ATOM   3670 C CA  B ASP A  1 427 ? -16.43904 6.13987   45.40843  0.464 31.23229 ? 426  ASP A CA  1 
ATOM   3671 C C   A ASP A  1 427 ? -15.18531 5.98031   44.54693  0.536 34.08480 ? 426  ASP A C   1 
ATOM   3672 C C   B ASP A  1 427 ? -15.45987 6.19563   44.24448  0.464 34.72537 ? 426  ASP A C   1 
ATOM   3673 O O   A ASP A  1 427 ? -14.21086 6.71796   44.72950  0.536 29.05872 ? 426  ASP A O   1 
ATOM   3674 O O   B ASP A  1 427 ? -14.92528 7.27089   43.95408  0.464 30.18477 ? 426  ASP A O   1 
ATOM   3675 C CB  A ASP A  1 427 ? -15.94917 6.30606   46.91164  0.536 32.96128 ? 426  ASP A CB  1 
ATOM   3676 C CB  B ASP A  1 427 ? -15.66182 6.20766   46.72410  0.464 34.09802 ? 426  ASP A CB  1 
ATOM   3677 C CG  A ASP A  1 427 ? -15.24146 5.09548   47.48963  0.536 41.01513 ? 426  ASP A CG  1 
ATOM   3678 C CG  B ASP A  1 427 ? -14.82662 4.96675   46.97061  0.464 37.51719 ? 426  ASP A CG  1 
ATOM   3679 O OD1 A ASP A  1 427 ? -15.61311 3.95772   47.13203  0.536 43.50892 ? 426  ASP A OD1 1 
ATOM   3680 O OD1 B ASP A  1 427 ? -15.40601 3.87372   47.13718  0.464 43.12304 ? 426  ASP A OD1 1 
ATOM   3681 O OD2 A ASP A  1 427 ? -14.32020 5.28101   48.31279  0.536 41.51063 ? 426  ASP A OD2 1 
ATOM   3682 O OD2 B ASP A  1 427 ? -13.58610 5.08643   46.99638  0.464 43.37284 ? 426  ASP A OD2 1 
ATOM   3683 N N   . TYR A  1 428 ? -15.21656 5.07437   43.57049  1.000 25.96579 ? 427  TYR A N   1 
ATOM   3684 C CA  . TYR A  1 428 ? -14.18969 5.02305   42.53862  1.000 28.53123 ? 427  TYR A CA  1 
ATOM   3685 C C   . TYR A  1 428 ? -14.68298 5.72935   41.28228  1.000 29.27683 ? 427  TYR A C   1 
ATOM   3686 O O   . TYR A  1 428 ? -15.76676 5.42430   40.77403  1.000 30.89501 ? 427  TYR A O   1 
ATOM   3687 C CB  . TYR A  1 428 ? -13.80829 3.58032   42.21466  1.000 23.50634 ? 427  TYR A CB  1 
ATOM   3688 C CG  . TYR A  1 428 ? -12.79185 3.51502   41.10211  1.000 22.96667 ? 427  TYR A CG  1 
ATOM   3689 C CD1 . TYR A  1 428 ? -11.46301 3.85941   41.32998  1.000 23.11457 ? 427  TYR A CD1 1 
ATOM   3690 C CD2 . TYR A  1 428 ? -13.16353 3.13239   39.81766  1.000 24.78551 ? 427  TYR A CD2 1 
ATOM   3691 C CE1 . TYR A  1 428 ? -10.52302 3.80406   40.30463  1.000 24.56469 ? 427  TYR A CE1 1 
ATOM   3692 C CE2 . TYR A  1 428 ? -12.23445 3.07534   38.79404  1.000 19.48080 ? 427  TYR A CE2 1 
ATOM   3693 C CZ  . TYR A  1 428 ? -10.91995 3.41296   39.04656  1.000 21.87827 ? 427  TYR A CZ  1 
ATOM   3694 O OH  . TYR A  1 428 ? -9.99272  3.36337   38.03302  1.000 21.92392 ? 427  TYR A OH  1 
ATOM   3695 N N   A ASP A  1 429 ? -13.85915 6.63538   40.75657  0.537 26.24717 ? 428  ASP A N   1 
ATOM   3696 N N   B ASP A  1 429 ? -13.90310 6.69304   40.79837  0.463 26.28219 ? 428  ASP A N   1 
ATOM   3697 C CA  A ASP A  1 429 ? -14.22855 7.50711   39.64546  0.537 31.02695 ? 428  ASP A CA  1 
ATOM   3698 C CA  B ASP A  1 429 ? -14.26681 7.46656   39.61940  0.463 31.00503 ? 428  ASP A CA  1 
ATOM   3699 C C   A ASP A  1 429 ? -13.12272 7.46606   38.59717  0.537 28.81252 ? 428  ASP A C   1 
ATOM   3700 C C   B ASP A  1 429 ? -13.12257 7.40042   38.62350  0.463 28.86879 ? 428  ASP A C   1 
ATOM   3701 O O   A ASP A  1 429 ? -12.02433 7.97813   38.83263  0.537 31.73496 ? 428  ASP A O   1 
ATOM   3702 O O   B ASP A  1 429 ? -12.00265 7.82084   38.92992  0.463 31.50250 ? 428  ASP A O   1 
ATOM   3703 C CB  A ASP A  1 429 ? -14.45697 8.93515   40.14895  0.537 33.20239 ? 428  ASP A CB  1 
ATOM   3704 C CB  B ASP A  1 429 ? -14.58369 8.92300   39.97403  0.463 33.48262 ? 428  ASP A CB  1 
ATOM   3705 C CG  A ASP A  1 429 ? -14.89902 9.89087   39.05465  0.537 33.62270 ? 428  ASP A CG  1 
ATOM   3706 C CG  B ASP A  1 429 ? -15.20605 9.68367   38.81171  0.463 34.07469 ? 428  ASP A CG  1 
ATOM   3707 O OD1 A ASP A  1 429 ? -15.19064 9.44225   37.92144  0.537 33.49174 ? 428  ASP A OD1 1 
ATOM   3708 O OD1 B ASP A  1 429 ? -14.49226 9.98072   37.82383  0.463 29.74967 ? 428  ASP A OD1 1 
ATOM   3709 O OD2 A ASP A  1 429 ? -14.96298 11.10667  39.34232  0.537 31.10997 ? 428  ASP A OD2 1 
ATOM   3710 O OD2 B ASP A  1 429 ? -16.41909 9.97948   38.88494  0.463 39.82317 ? 428  ASP A OD2 1 
ATOM   3711 N N   . ASP A  1 430 ? -13.40222 6.86273   37.44011  1.000 24.92657 ? 429  ASP A N   1 
ATOM   3712 C CA  . ASP A  1 430 ? -12.43615 6.84793   36.34957  1.000 25.04373 ? 429  ASP A CA  1 
ATOM   3713 C C   . ASP A  1 430 ? -12.91003 7.67610   35.16335  1.000 27.39029 ? 429  ASP A C   1 
ATOM   3714 O O   . ASP A  1 430 ? -12.39133 7.51477   34.05478  1.000 26.21932 ? 429  ASP A O   1 
ATOM   3715 C CB  . ASP A  1 430 ? -12.09982 5.41189   35.92579  1.000 24.43526 ? 429  ASP A CB  1 
ATOM   3716 C CG  . ASP A  1 430 ? -13.30432 4.62429   35.44074  1.000 26.42610 ? 429  ASP A CG  1 
ATOM   3717 O OD1 . ASP A  1 430 ? -14.39238 5.20497   35.21004  1.000 25.41083 ? 429  ASP A OD1 1 
ATOM   3718 O OD2 . ASP A  1 430 ? -13.15206 3.39107   35.28570  1.000 26.42409 ? 429  ASP A OD2 1 
ATOM   3719 N N   . SER A  1 431 ? -13.87144 8.58568   35.38462  1.000 27.45845 ? 430  SER A N   1 
ATOM   3720 C CA  . SER A  1 431 ? -14.36610 9.41311   34.28945  1.000 25.64288 ? 430  SER A CA  1 
ATOM   3721 C C   . SER A  1 431 ? -13.24248 10.22091  33.65621  1.000 26.27753 ? 430  SER A C   1 
ATOM   3722 O O   . SER A  1 431 ? -13.27905 10.50804  32.45351  1.000 35.22670 ? 430  SER A O   1 
ATOM   3723 C CB  . SER A  1 431 ? -15.47746 10.34588  34.78595  1.000 31.48300 ? 430  SER A CB  1 
ATOM   3724 O OG  . SER A  1 431 ? -15.02357 11.15830  35.85888  1.000 32.91905 ? 430  SER A OG  1 
ATOM   3725 N N   . GLN A  1 432 ? -12.22248 10.56481  34.43420  1.000 28.51760 ? 431  GLN A N   1 
ATOM   3726 C CA  . GLN A  1 432 ? -11.11774 11.37404  33.94709  1.000 36.54126 ? 431  GLN A CA  1 
ATOM   3727 C C   . GLN A  1 432 ? -9.87285  10.55209  33.63844  1.000 32.86872 ? 431  GLN A C   1 
ATOM   3728 O O   . GLN A  1 432 ? -8.82354  11.12878  33.34486  1.000 29.89654 ? 431  GLN A O   1 
ATOM   3729 C CB  . GLN A  1 432 ? -10.78109 12.46271  34.96844  1.000 36.58655 ? 431  GLN A CB  1 
ATOM   3730 C CG  . GLN A  1 432 ? -11.94559 13.39284  35.24873  1.000 41.50614 ? 431  GLN A CG  1 
ATOM   3731 C CD  . GLN A  1 432 ? -12.36683 14.16738  34.02230  1.000 49.61543 ? 431  GLN A CD  1 
ATOM   3732 O OE1 . GLN A  1 432 ? -13.55289 14.23116  33.69677  1.000 57.88268 ? 431  GLN A OE1 1 
ATOM   3733 N NE2 . GLN A  1 432 ? -11.39736 14.76463  33.33123  1.000 60.42096 ? 431  GLN A NE2 1 
ATOM   3734 N N   . LEU A  1 433 ? -9.95506  9.22649   33.71203  1.000 26.93774 ? 432  LEU A N   1 
ATOM   3735 C CA  . LEU A  1 433 ? -8.79802  8.39478   33.40371  1.000 25.10182 ? 432  LEU A CA  1 
ATOM   3736 C C   . LEU A  1 433 ? -8.50198  8.45312   31.90666  1.000 22.73959 ? 432  LEU A C   1 
ATOM   3737 O O   . LEU A  1 433 ? -9.34389  8.08922   31.08288  1.000 24.89802 ? 432  LEU A O   1 
ATOM   3738 C CB  . LEU A  1 433 ? -9.05028  6.95883   33.85965  1.000 25.09544 ? 432  LEU A CB  1 
ATOM   3739 C CG  . LEU A  1 433 ? -7.87926  5.99673   33.64814  1.000 26.19521 ? 432  LEU A CG  1 
ATOM   3740 C CD1 . LEU A  1 433 ? -6.75575  6.25693   34.63789  1.000 25.95138 ? 432  LEU A CD1 1 
ATOM   3741 C CD2 . LEU A  1 433 ? -8.35090  4.54970   33.72898  1.000 22.86627 ? 432  LEU A CD2 1 
ATOM   3742 N N   A ASP A  1 434 ? -7.30200  8.90859   31.55885  0.610 26.16705 ? 433  ASP A N   1 
ATOM   3743 N N   B ASP A  1 434 ? -7.30570  8.91190   31.55613  0.390 26.18975 ? 433  ASP A N   1 
ATOM   3744 C CA  A ASP A  1 434 ? -6.92424  9.11648   30.16668  0.610 25.94203 ? 433  ASP A CA  1 
ATOM   3745 C CA  B ASP A  1 434 ? -6.94713  9.11791   30.15927  0.390 25.96177 ? 433  ASP A CA  1 
ATOM   3746 C C   A ASP A  1 434 ? -6.47303  7.79280   29.55811  0.610 24.78312 ? 433  ASP A C   1 
ATOM   3747 C C   B ASP A  1 434 ? -6.47643  7.80262   29.55184  0.390 24.82448 ? 433  ASP A C   1 
ATOM   3748 O O   A ASP A  1 434 ? -5.43302  7.24753   29.93616  0.610 22.90861 ? 433  ASP A O   1 
ATOM   3749 O O   B ASP A  1 434 ? -5.42554  7.27543   29.92556  0.390 22.98431 ? 433  ASP A O   1 
ATOM   3750 C CB  A ASP A  1 434 ? -5.82204  10.16786  30.07628  0.610 27.54315 ? 433  ASP A CB  1 
ATOM   3751 C CB  B ASP A  1 434 ? -5.86913  10.18824  30.04007  0.390 27.58420 ? 433  ASP A CB  1 
ATOM   3752 C CG  A ASP A  1 434 ? -5.63257  10.70170  28.66369  0.610 31.93591 ? 433  ASP A CG  1 
ATOM   3753 C CG  B ASP A  1 434 ? -5.45250  10.42986  28.60312  0.390 30.33480 ? 433  ASP A CG  1 
ATOM   3754 O OD1 A ASP A  1 434 ? -5.50070  9.88953   27.72523  0.610 22.53372 ? 433  ASP A OD1 1 
ATOM   3755 O OD1 B ASP A  1 434 ? -6.33383  10.71811  27.76566  0.390 35.63485 ? 433  ASP A OD1 1 
ATOM   3756 O OD2 A ASP A  1 434 ? -5.62223  11.93971  28.48609  0.610 36.10017 ? 433  ASP A OD2 1 
ATOM   3757 O OD2 B ASP A  1 434 ? -4.24297  10.33374  28.31146  0.390 32.12510 ? 433  ASP A OD2 1 
ATOM   3758 N N   . MET A  1 435 ? -7.24836  7.27666   28.60168  1.000 24.47373 ? 434  MET A N   1 
ATOM   3759 C CA  . MET A  1 435 ? -6.87455  6.05326   27.88751  1.000 22.27540 ? 434  MET A CA  1 
ATOM   3760 C C   . MET A  1 435 ? -5.72454  6.21241   26.90947  1.000 24.04683 ? 434  MET A C   1 
ATOM   3761 O O   . MET A  1 435 ? -5.33420  5.20241   26.31797  1.000 22.88308 ? 434  MET A O   1 
ATOM   3762 C CB  . MET A  1 435 ? -8.10636  5.46577   27.18085  1.000 22.43692 ? 434  MET A CB  1 
ATOM   3763 C CG  . MET A  1 435 ? -9.33040  5.22495   28.07476  1.000 21.79465 ? 434  MET A CG  1 
ATOM   3764 S SD  . MET A  1 435 ? -8.93436  3.95859   29.32609  1.000 22.51567 ? 434  MET A SD  1 
ATOM   3765 C CE  . MET A  1 435 ? -9.31612  2.52669   28.30783  1.000 21.97227 ? 434  MET A CE  1 
ATOM   3766 N N   . GLY A  1 436 ? -5.15239  7.40188   26.74226  1.000 22.76524 ? 435  GLY A N   1 
ATOM   3767 C CA  . GLY A  1 436 ? -3.93085  7.54497   25.97460  1.000 20.69097 ? 435  GLY A CA  1 
ATOM   3768 C C   . GLY A  1 436 ? -4.14045  7.56312   24.46797  1.000 21.42002 ? 435  GLY A C   1 
ATOM   3769 O O   . GLY A  1 436 ? -5.25792  7.53618   23.94596  1.000 24.40221 ? 435  GLY A O   1 
ATOM   3770 N N   . THR A  1 437 ? -3.00994  7.62622   23.76173  1.000 18.83710 ? 436  THR A N   1 
ATOM   3771 C CA  . THR A  1 437 ? -2.96895  7.67935   22.30583  1.000 21.07971 ? 436  THR A CA  1 
ATOM   3772 C C   . THR A  1 437 ? -2.33660  6.42479   21.70851  1.000 22.56310 ? 436  THR A C   1 
ATOM   3773 O O   . THR A  1 437 ? -1.88711  6.44311   20.55483  1.000 22.27155 ? 436  THR A O   1 
ATOM   3774 C CB  . THR A  1 437 ? -2.21818  8.93052   21.85108  1.000 29.46722 ? 436  THR A CB  1 
ATOM   3775 O OG1 . THR A  1 437 ? -0.90016  8.92075   22.41129  1.000 27.95119 ? 436  THR A OG1 1 
ATOM   3776 C CG2 . THR A  1 437 ? -2.95347  10.18363  22.31881  1.000 27.63245 ? 436  THR A CG2 1 
ATOM   3777 N N   . GLY A  1 438 ? -2.30189  5.32971   22.47067  1.000 23.34357 ? 437  GLY A N   1 
ATOM   3778 C CA  . GLY A  1 438 ? -1.90225  4.05969   21.90160  1.000 18.90803 ? 437  GLY A CA  1 
ATOM   3779 C C   . GLY A  1 438 ? -2.76277  3.68649   20.70933  1.000 21.64940 ? 437  GLY A C   1 
ATOM   3780 O O   . GLY A  1 438 ? -3.87538  4.18712   20.52468  1.000 22.50358 ? 437  GLY A O   1 
ATOM   3781 N N   . LEU A  1 439 ? -2.22657  2.79946   19.87900  1.000 20.56044 ? 438  LEU A N   1 
ATOM   3782 C CA  . LEU A  1 439 ? -2.89508  2.43469   18.63446  1.000 21.34752 ? 438  LEU A CA  1 
ATOM   3783 C C   . LEU A  1 439 ? -4.13059  1.59527   18.91944  1.000 21.35968 ? 438  LEU A C   1 
ATOM   3784 O O   . LEU A  1 439 ? -4.04012  0.53258   19.54167  1.000 20.83966 ? 438  LEU A O   1 
ATOM   3785 C CB  . LEU A  1 439 ? -1.93620  1.67292   17.72887  1.000 18.98872 ? 438  LEU A CB  1 
ATOM   3786 C CG  . LEU A  1 439 ? -0.64419  2.41024   17.37572  1.000 25.02656 ? 438  LEU A CG  1 
ATOM   3787 C CD1 . LEU A  1 439 ? 0.24844   1.50744   16.55480  1.000 25.52310 ? 438  LEU A CD1 1 
ATOM   3788 C CD2 . LEU A  1 439 ? -0.94391  3.70697   16.63159  1.000 25.22585 ? 438  LEU A CD2 1 
ATOM   3789 N N   . ARG A  1 440 ? -5.28157  2.06136   18.44722  1.000 21.20254 ? 439  ARG A N   1 
ATOM   3790 C CA  . ARG A  1 440 ? -6.50553  1.28405   18.50270  1.000 17.99832 ? 439  ARG A CA  1 
ATOM   3791 C C   . ARG A  1 440 ? -6.60813  0.37110   17.28669  1.000 18.17608 ? 439  ARG A C   1 
ATOM   3792 O O   . ARG A  1 440 ? -6.11011  0.68567   16.20276  1.000 21.54556 ? 439  ARG A O   1 
ATOM   3793 C CB  . ARG A  1 440 ? -7.73213  2.19382   18.55316  1.000 20.80946 ? 439  ARG A CB  1 
ATOM   3794 C CG  . ARG A  1 440 ? -8.18637  2.52880   19.95949  1.000 24.87475 ? 439  ARG A CG  1 
ATOM   3795 C CD  . ARG A  1 440 ? -7.22354  3.47991   20.59178  1.000 25.88207 ? 439  ARG A CD  1 
ATOM   3796 N NE  . ARG A  1 440 ? -7.77940  4.02948   21.81786  1.000 23.05737 ? 439  ARG A NE  1 
ATOM   3797 C CZ  . ARG A  1 440 ? -7.07513  4.69397   22.72116  1.000 25.47770 ? 439  ARG A CZ  1 
ATOM   3798 N NH1 . ARG A  1 440 ? -5.77867  4.91084   22.56171  1.000 27.43738 ? 439  ARG A NH1 1 
ATOM   3799 N NH2 . ARG A  1 440 ? -7.68682  5.14731   23.81128  1.000 25.87935 ? 439  ARG A NH2 1 
ATOM   3800 N N   . TYR A  1 441 ? -7.25268  -0.77393  17.48316  1.000 18.58621 ? 440  TYR A N   1 
ATOM   3801 C CA  . TYR A  1 441 ? -7.60134  -1.62628  16.35586  1.000 18.47413 ? 440  TYR A CA  1 
ATOM   3802 C C   . TYR A  1 441 ? -8.75531  -0.97787  15.60247  1.000 26.36112 ? 440  TYR A C   1 
ATOM   3803 O O   . TYR A  1 441 ? -9.84128  -0.79809  16.16445  1.000 28.95157 ? 440  TYR A O   1 
ATOM   3804 C CB  . TYR A  1 441 ? -7.99005  -3.02255  16.83246  1.000 18.46230 ? 440  TYR A CB  1 
ATOM   3805 C CG  . TYR A  1 441 ? -8.17657  -4.00948  15.68946  1.000 18.71944 ? 440  TYR A CG  1 
ATOM   3806 C CD1 . TYR A  1 441 ? -7.08818  -4.70357  15.16377  1.000 17.13972 ? 440  TYR A CD1 1 
ATOM   3807 C CD2 . TYR A  1 441 ? -9.43643  -4.25820  15.14926  1.000 20.93230 ? 440  TYR A CD2 1 
ATOM   3808 C CE1 . TYR A  1 441 ? -7.23917  -5.61482  14.12491  1.000 17.28594 ? 440  TYR A CE1 1 
ATOM   3809 C CE2 . TYR A  1 441 ? -9.60254  -5.17022  14.09754  1.000 19.06830 ? 440  TYR A CE2 1 
ATOM   3810 C CZ  . TYR A  1 441 ? -8.49816  -5.84358  13.59680  1.000 17.91075 ? 440  TYR A CZ  1 
ATOM   3811 O OH  . TYR A  1 441 ? -8.64855  -6.75308  12.57715  1.000 17.72939 ? 440  TYR A OH  1 
ATOM   3812 N N   . THR A  1 442 ? -8.52030  -0.63311  14.34179  1.000 27.45032 ? 441  THR A N   1 
ATOM   3813 C CA  . THR A  1 442 ? -9.45316  0.18309   13.57663  1.000 31.82305 ? 441  THR A CA  1 
ATOM   3814 C C   . THR A  1 442 ? -10.44599 -0.63371  12.75539  1.000 37.54729 ? 441  THR A C   1 
ATOM   3815 O O   . THR A  1 442 ? -11.28736 -0.04102  12.07150  1.000 28.58554 ? 441  THR A O   1 
ATOM   3816 C CB  . THR A  1 442 ? -8.68065  1.12520   12.64120  1.000 24.33008 ? 441  THR A CB  1 
ATOM   3817 O OG1 . THR A  1 442 ? -7.90285  0.34983   11.71445  1.000 37.87329 ? 441  THR A OG1 1 
ATOM   3818 C CG2 . THR A  1 442 ? -7.75535  2.03873   13.43525  1.000 41.62634 ? 441  THR A CG2 1 
ATOM   3819 N N   . GLY A  1 443 ? -10.38611 -1.96115  12.81996  1.000 25.81458 ? 442  GLY A N   1 
ATOM   3820 C CA  . GLY A  1 443 ? -11.21442 -2.78081  11.94792  1.000 21.83909 ? 442  GLY A CA  1 
ATOM   3821 C C   . GLY A  1 443 ? -12.69725 -2.62620  12.24220  1.000 23.64020 ? 442  GLY A C   1 
ATOM   3822 O O   . GLY A  1 443 ? -13.12146 -2.49972  13.39081  1.000 21.16383 ? 442  GLY A O   1 
ATOM   3823 N N   . VAL A  1 444 ? -13.49359 -2.63851  11.18087  1.000 18.24809 ? 443  VAL A N   1 
ATOM   3824 C CA  . VAL A  1 444 ? -14.94870 -2.64543  11.27086  1.000 18.86341 ? 443  VAL A CA  1 
ATOM   3825 C C   . VAL A  1 444 ? -15.47797 -3.82646  10.47498  1.000 20.80368 ? 443  VAL A C   1 
ATOM   3826 O O   . VAL A  1 444 ? -15.01213 -4.09776  9.35979   1.000 20.85743 ? 443  VAL A O   1 
ATOM   3827 C CB  . VAL A  1 444 ? -15.55483 -1.32134  10.76270  1.000 25.68322 ? 443  VAL A CB  1 
ATOM   3828 C CG1 . VAL A  1 444 ? -17.08552 -1.40374  10.72878  1.000 27.89117 ? 443  VAL A CG1 1 
ATOM   3829 C CG2 . VAL A  1 444 ? -15.08718 -0.18107  11.64135  1.000 26.15580 ? 443  VAL A CG2 1 
ATOM   3830 N N   . GLY A  1 445 ? -16.43603 -4.53417  11.06123  1.000 18.73335 ? 444  GLY A N   1 
ATOM   3831 C CA  . GLY A  1 445 ? -17.08501 -5.66085  10.43855  1.000 18.64937 ? 444  GLY A CA  1 
ATOM   3832 C C   . GLY A  1 445 ? -18.58949 -5.52147  10.54886  1.000 18.23299 ? 444  GLY A C   1 
ATOM   3833 O O   . GLY A  1 445 ? -19.09874 -4.51080  11.05151  1.000 21.84387 ? 444  GLY A O   1 
ATOM   3834 N N   . PRO A  1 446 ? -19.32541 -6.55588  10.12669  1.000 21.80241 ? 445  PRO A N   1 
ATOM   3835 C CA  . PRO A  1 446 ? -20.80006 -6.47534  10.14413  1.000 26.81514 ? 445  PRO A CA  1 
ATOM   3836 C C   . PRO A  1 446 ? -21.39063 -6.30343  11.52784  1.000 31.28584 ? 445  PRO A C   1 
ATOM   3837 O O   . PRO A  1 446 ? -22.50345 -5.77495  11.65694  1.000 27.66305 ? 445  PRO A O   1 
ATOM   3838 C CB  . PRO A  1 446 ? -21.23503 -7.82093  9.54005   1.000 28.30967 ? 445  PRO A CB  1 
ATOM   3839 C CG  . PRO A  1 446 ? -20.03174 -8.36522  8.86160   1.000 29.62774 ? 445  PRO A CG  1 
ATOM   3840 C CD  . PRO A  1 446 ? -18.84673 -7.84447  9.60084   1.000 23.05355 ? 445  PRO A CD  1 
ATOM   3841 N N   . GLY A  1 447 ? -20.69861 -6.76653  12.56598  1.000 20.97546 ? 446  GLY A N   1 
ATOM   3842 C CA  . GLY A  1 447 ? -21.22080 -6.73772  13.91337  1.000 21.21791 ? 446  GLY A CA  1 
ATOM   3843 C C   . GLY A  1 447 ? -20.91952 -5.49389  14.70887  1.000 25.48914 ? 446  GLY A C   1 
ATOM   3844 O O   . GLY A  1 447 ? -21.39976 -5.38299  15.84119  1.000 25.99664 ? 446  GLY A O   1 
ATOM   3845 N N   . ASN A  1 448 ? -20.14009 -4.54862  14.17564  1.000 23.36656 ? 447  ASN A N   1 
ATOM   3846 C CA  . ASN A  1 448 ? -19.79279 -3.34700  14.93888  1.000 23.15598 ? 447  ASN A CA  1 
ATOM   3847 C C   . ASN A  1 448 ? -19.81176 -2.11157  14.04662  1.000 21.35632 ? 447  ASN A C   1 
ATOM   3848 O O   . ASN A  1 448 ? -18.94659 -1.23442  14.14315  1.000 24.68264 ? 447  ASN A O   1 
ATOM   3849 C CB  . ASN A  1 448 ? -18.44773 -3.49931  15.66921  1.000 21.11668 ? 447  ASN A CB  1 
ATOM   3850 C CG  . ASN A  1 448 ? -17.24013 -3.47169  14.74251  1.000 26.25333 ? 447  ASN A CG  1 
ATOM   3851 O OD1 . ASN A  1 448 ? -17.30627 -3.90471  13.59302  1.000 22.77561 ? 447  ASN A OD1 1 
ATOM   3852 N ND2 . ASN A  1 448 ? -16.12440 -2.95747  15.24939  1.000 24.86847 ? 447  ASN A ND2 1 
ATOM   3853 N N   . LEU A  1 449 ? -20.82420 -2.01487  13.19448  1.000 23.59874 ? 448  LEU A N   1 
ATOM   3854 C CA  . LEU A  1 449 ? -20.97323 -0.84492  12.34722  1.000 25.93118 ? 448  LEU A CA  1 
ATOM   3855 C C   . LEU A  1 449 ? -21.19612 0.38821   13.21443  1.000 32.59521 ? 448  LEU A C   1 
ATOM   3856 O O   . LEU A  1 449 ? -22.07725 0.37671   14.08854  1.000 32.89027 ? 448  LEU A O   1 
ATOM   3857 C CB  . LEU A  1 449 ? -22.15096 -1.02593  11.39734  1.000 26.94140 ? 448  LEU A CB  1 
ATOM   3858 C CG  . LEU A  1 449 ? -22.01149 -2.07943  10.30077  1.000 27.06995 ? 448  LEU A CG  1 
ATOM   3859 C CD1 . LEU A  1 449 ? -23.35163 -2.28465  9.62102   1.000 33.45875 ? 448  LEU A CD1 1 
ATOM   3860 C CD2 . LEU A  1 449 ? -20.95415 -1.67665  9.30137   1.000 27.19342 ? 448  LEU A CD2 1 
ATOM   3861 N N   . PRO A  1 450 ? -20.43414 1.45547   13.01624  1.000 31.97664 ? 449  PRO A N   1 
ATOM   3862 C CA  . PRO A  1 450 ? -20.66623 2.67509   13.79394  1.000 36.42759 ? 449  PRO A CA  1 
ATOM   3863 C C   . PRO A  1 450 ? -21.94071 3.36442   13.33739  1.000 36.96346 ? 449  PRO A C   1 
ATOM   3864 O O   . PRO A  1 450 ? -22.39460 3.20213   12.20251  1.000 33.63248 ? 449  PRO A O   1 
ATOM   3865 C CB  . PRO A  1 450 ? -19.43454 3.52717   13.48139  1.000 31.11074 ? 449  PRO A CB  1 
ATOM   3866 C CG  . PRO A  1 450 ? -19.07667 3.11020   12.07128  1.000 34.79440 ? 449  PRO A CG  1 
ATOM   3867 C CD  . PRO A  1 450 ? -19.34957 1.62087   12.03223  1.000 31.39362 ? 449  PRO A CD  1 
ATOM   3868 N N   A ILE A  1 451 ? -22.52959 4.14071   14.24732  0.457 33.82642 ? 450  ILE A N   1 
ATOM   3869 N N   B ILE A  1 451 ? -22.53554 4.13371   14.24948  0.543 33.78569 ? 450  ILE A N   1 
ATOM   3870 C CA  A ILE A  1 451 ? -23.66433 4.97465   13.87157  0.457 35.40568 ? 450  ILE A CA  1 
ATOM   3871 C CA  B ILE A  1 451 ? -23.66371 4.97237   13.86772  0.543 35.38693 ? 450  ILE A CA  1 
ATOM   3872 C C   A ILE A  1 451 ? -23.16145 6.12889   13.01516  0.457 33.14535 ? 450  ILE A C   1 
ATOM   3873 C C   B ILE A  1 451 ? -23.14811 6.11221   13.00126  0.543 33.11768 ? 450  ILE A C   1 
ATOM   3874 O O   A ILE A  1 451 ? -22.15176 6.76925   13.33847  0.457 34.39164 ? 450  ILE A O   1 
ATOM   3875 O O   B ILE A  1 451 ? -22.11653 6.72678   13.30552  0.543 34.36115 ? 450  ILE A O   1 
ATOM   3876 C CB  A ILE A  1 451 ? -24.41457 5.47195   15.11736  0.457 42.74282 ? 450  ILE A CB  1 
ATOM   3877 C CB  B ILE A  1 451 ? -24.40650 5.49479   15.10707  0.543 42.78832 ? 450  ILE A CB  1 
ATOM   3878 C CG1 A ILE A  1 451 ? -25.11050 4.30174   15.81828  0.457 38.68638 ? 450  ILE A CG1 1 
ATOM   3879 C CG1 B ILE A  1 451 ? -24.87970 4.32752   15.97432  0.543 38.72927 ? 450  ILE A CG1 1 
ATOM   3880 C CG2 A ILE A  1 451 ? -25.43266 6.54020   14.74052  0.457 37.46513 ? 450  ILE A CG2 1 
ATOM   3881 C CG2 B ILE A  1 451 ? -25.59787 6.34856   14.69113  0.543 37.27053 ? 450  ILE A CG2 1 
ATOM   3882 C CD1 A ILE A  1 451 ? -25.16064 4.42947   17.32779  0.457 50.53840 ? 450  ILE A CD1 1 
ATOM   3883 C CD1 B ILE A  1 451 ? -24.34133 4.36414   17.38876  0.543 53.22931 ? 450  ILE A CD1 1 
ATOM   3884 N N   . MET A  1 452 ? -23.84579 6.37900   11.89903  1.000 36.98713 ? 451  MET A N   1 
ATOM   3885 C CA  A MET A  1 452 ? -23.44156 7.40265   10.94762  0.430 33.77587 ? 451  MET A CA  1 
ATOM   3886 C CA  B MET A  1 452 ? -23.43688 7.40670   10.95372  0.570 33.75380 ? 451  MET A CA  1 
ATOM   3887 C C   . MET A  1 452 ? -24.66817 8.11984   10.41167  1.000 30.88228 ? 451  MET A C   1 
ATOM   3888 O O   . MET A  1 452 ? -25.80023 7.64752   10.54140  1.000 34.34864 ? 451  MET A O   1 
ATOM   3889 C CB  A MET A  1 452 ? -22.66498 6.81270   9.76774   0.430 33.31724 ? 451  MET A CB  1 
ATOM   3890 C CB  B MET A  1 452 ? -22.61520 6.82023   9.79038   0.570 33.36149 ? 451  MET A CB  1 
ATOM   3891 C CG  A MET A  1 452 ? -21.38972 6.10061   10.12347  0.430 33.62000 ? 451  MET A CG  1 
ATOM   3892 C CG  B MET A  1 452 ? -21.22091 6.32136   10.17264  0.570 33.31578 ? 451  MET A CG  1 
ATOM   3893 S SD  A MET A  1 452 ? -20.71916 5.40673   8.61373   0.430 30.39035 ? 451  MET A SD  1 
ATOM   3894 S SD  B MET A  1 452 ? -20.30377 5.61648   8.77983   0.570 34.00345 ? 451  MET A SD  1 
ATOM   3895 C CE  A MET A  1 452 ? -18.97255 5.35411   8.99738   0.430 27.07408 ? 451  MET A CE  1 
ATOM   3896 C CE  B MET A  1 452 ? -19.87527 7.09636   7.86519   0.570 24.77490 ? 451  MET A CE  1 
ATOM   3897 N N   . THR A  1 453 ? -24.42066 9.26801   9.78005   1.000 37.48980 ? 452  THR A N   1 
ATOM   3898 C CA  . THR A  1 453 ? -25.42807 10.01261  9.04179   1.000 38.70736 ? 452  THR A CA  1 
ATOM   3899 C C   . THR A  1 453 ? -24.88748 10.27297  7.64379   1.000 27.19603 ? 452  THR A C   1 
ATOM   3900 O O   . THR A  1 453 ? -23.67451 10.39498  7.44938   1.000 37.89200 ? 452  THR A O   1 
ATOM   3901 C CB  . THR A  1 453 ? -25.77133 11.36377  9.70104   1.000 39.79305 ? 452  THR A CB  1 
ATOM   3902 O OG1 . THR A  1 453 ? -24.60042 12.19372  9.71661   1.000 49.06436 ? 452  THR A OG1 1 
ATOM   3903 C CG2 . THR A  1 453 ? -26.24319 11.16188  11.12922  1.000 44.78497 ? 452  THR A CG2 1 
ATOM   3904 N N   . ALA A  1 454 ? -25.79278 10.37235  6.67434   1.000 32.88564 ? 453  ALA A N   1 
ATOM   3905 C CA  . ALA A  1 454 ? -25.40462 10.73199  5.31546   1.000 38.12597 ? 453  ALA A CA  1 
ATOM   3906 C C   . ALA A  1 454 ? -26.64814 11.15241  4.55353   1.000 35.69679 ? 453  ALA A C   1 
ATOM   3907 O O   . ALA A  1 454 ? -27.75308 10.71792  4.89957   1.000 37.33043 ? 453  ALA A O   1 
ATOM   3908 C CB  . ALA A  1 454 ? -24.71511 9.55757   4.60136   1.000 32.75892 ? 453  ALA A CB  1 
ATOM   3909 N N   . PRO A  1 455 ? -26.50916 11.97836  3.50987   1.000 31.89280 ? 454  PRO A N   1 
ATOM   3910 C CA  . PRO A  1 455 ? -27.67550 12.32133  2.69327   1.000 32.12646 ? 454  PRO A CA  1 
ATOM   3911 C C   . PRO A  1 455 ? -28.31725 11.07149  2.12429   1.000 33.44781 ? 454  PRO A C   1 
ATOM   3912 O O   . PRO A  1 455 ? -27.64081 10.09160  1.80362   1.000 33.96795 ? 454  PRO A O   1 
ATOM   3913 C CB  . PRO A  1 455 ? -27.08905 13.20300  1.58007   1.000 35.60880 ? 454  PRO A CB  1 
ATOM   3914 C CG  . PRO A  1 455 ? -25.81697 13.73524  2.14967   1.000 36.87393 ? 454  PRO A CG  1 
ATOM   3915 C CD  . PRO A  1 455 ? -25.28519 12.64577  3.03191   1.000 34.01034 ? 454  PRO A CD  1 
ATOM   3916 N N   . ALA A  1 456 ? -29.63903 11.11218  1.99952   1.000 30.20857 ? 455  ALA A N   1 
ATOM   3917 C CA  . ALA A  1 456 ? -30.35542 9.98152   1.43491   1.000 31.28234 ? 455  ALA A CA  1 
ATOM   3918 C C   . ALA A  1 456 ? -29.88258 9.71391   0.01354   1.000 40.15985 ? 455  ALA A C   1 
ATOM   3919 O O   . ALA A  1 456 ? -29.55692 10.64166  -0.73594  1.000 34.10157 ? 455  ALA A O   1 
ATOM   3920 C CB  . ALA A  1 456 ? -31.86019 10.23987  1.44544   1.000 36.09633 ? 455  ALA A CB  1 
ATOM   3921 N N   . TYR A  1 457 ? -29.83680 8.43192   -0.34671  1.000 32.27226 ? 456  TYR A N   1 
ATOM   3922 C CA  . TYR A  1 457 ? -29.52208 8.04340   -1.71160  1.000 27.51652 ? 456  TYR A CA  1 
ATOM   3923 C C   . TYR A  1 457 ? -30.57660 8.58511   -2.66668  1.000 40.37850 ? 456  TYR A C   1 
ATOM   3924 O O   . TYR A  1 457 ? -31.77284 8.58378   -2.36289  1.000 32.47676 ? 456  TYR A O   1 
ATOM   3925 C CB  . TYR A  1 457 ? -29.44404 6.51503   -1.82648  1.000 30.42012 ? 456  TYR A CB  1 
ATOM   3926 C CG  . TYR A  1 457 ? -29.46496 5.99372   -3.24265  1.000 28.58577 ? 456  TYR A CG  1 
ATOM   3927 C CD1 . TYR A  1 457 ? -28.34187 6.10247   -4.06412  1.000 27.76647 ? 456  TYR A CD1 1 
ATOM   3928 C CD2 . TYR A  1 457 ? -30.59768 5.38219   -3.76503  1.000 27.89507 ? 456  TYR A CD2 1 
ATOM   3929 C CE1 . TYR A  1 457 ? -28.35280 5.62728   -5.35187  1.000 27.87436 ? 456  TYR A CE1 1 
ATOM   3930 C CE2 . TYR A  1 457 ? -30.61650 4.89758   -5.05567  1.000 29.31774 ? 456  TYR A CE2 1 
ATOM   3931 C CZ  . TYR A  1 457 ? -29.49120 5.02999   -5.85095  1.000 29.06435 ? 456  TYR A CZ  1 
ATOM   3932 O OH  . TYR A  1 457 ? -29.50054 4.56291   -7.13642  1.000 30.60543 ? 456  TYR A OH  1 
ATOM   3933 N N   . VAL A  1 458 ? -30.12758 9.04672   -3.82925  1.000 31.98131 ? 457  VAL A N   1 
ATOM   3934 C CA  . VAL A  1 458 ? -31.02199 9.63800   -4.82586  1.000 35.71371 ? 457  VAL A CA  1 
ATOM   3935 C C   . VAL A  1 458 ? -30.85729 8.89192   -6.14403  1.000 33.29795 ? 457  VAL A C   1 
ATOM   3936 O O   . VAL A  1 458 ? -29.78191 8.94949   -6.75815  1.000 33.83198 ? 457  VAL A O   1 
ATOM   3937 C CB  . VAL A  1 458 ? -30.74659 11.14055  -5.00435  1.000 37.49549 ? 457  VAL A CB  1 
ATOM   3938 C CG1 . VAL A  1 458 ? -31.71273 11.74184  -6.01957  1.000 35.66324 ? 457  VAL A CG1 1 
ATOM   3939 C CG2 . VAL A  1 458 ? -30.84023 11.86856  -3.67511  1.000 35.17786 ? 457  VAL A CG2 1 
ATOM   3940 N N   . PRO A  1 459 ? -31.87743 8.17386   -6.61069  1.000 30.78705 ? 458  PRO A N   1 
ATOM   3941 C CA  . PRO A  1 459 ? -31.76244 7.48735   -7.89874  1.000 27.82760 ? 458  PRO A CA  1 
ATOM   3942 C C   . PRO A  1 459 ? -31.45366 8.47847   -9.01106  1.000 39.86634 ? 458  PRO A C   1 
ATOM   3943 O O   . PRO A  1 459 ? -31.91668 9.62027   -8.99613  1.000 35.04906 ? 458  PRO A O   1 
ATOM   3944 C CB  . PRO A  1 459 ? -33.14459 6.85288   -8.08728  1.000 36.14155 ? 458  PRO A CB  1 
ATOM   3945 C CG  . PRO A  1 459 ? -33.65943 6.68784   -6.69811  1.000 35.64929 ? 458  PRO A CG  1 
ATOM   3946 C CD  . PRO A  1 459 ? -33.15220 7.87503   -5.93438  1.000 36.89257 ? 458  PRO A CD  1 
ATOM   3947 N N   . GLY A  1 460 ? -30.64462 8.03349   -9.97047  1.000 30.96854 ? 459  GLY A N   1 
ATOM   3948 C CA  . GLY A  1 460 ? -30.25083 8.86086   -11.09219 1.000 29.78684 ? 459  GLY A CA  1 
ATOM   3949 C C   . GLY A  1 460 ? -29.03034 9.71973   -10.85444 1.000 32.18192 ? 459  GLY A C   1 
ATOM   3950 O O   . GLY A  1 460 ? -28.49419 10.29027  -11.81073 1.000 35.51835 ? 459  GLY A O   1 
ATOM   3951 N N   . THR A  1 461 ? -28.57303 9.83101   -9.61762  1.000 24.13646 ? 460  THR A N   1 
ATOM   3952 C CA  . THR A  1 461 ? -27.38260 10.60675  -9.31832  1.000 26.50728 ? 460  THR A CA  1 
ATOM   3953 C C   . THR A  1 461 ? -26.13956 9.75357   -9.54529  1.000 30.87631 ? 460  THR A C   1 
ATOM   3954 O O   . THR A  1 461 ? -26.15026 8.54221   -9.30886  1.000 27.73780 ? 460  THR A O   1 
ATOM   3955 C CB  . THR A  1 461 ? -27.46133 11.11585  -7.88457  1.000 29.32407 ? 460  THR A CB  1 
ATOM   3956 O OG1 . THR A  1 461 ? -28.58563 11.99534  -7.77454  1.000 34.93475 ? 460  THR A OG1 1 
ATOM   3957 C CG2 . THR A  1 461 ? -26.20945 11.86653  -7.47911  1.000 26.79986 ? 460  THR A CG2 1 
ATOM   3958 N N   . THR A  1 462 ? -25.07972 10.37953  -10.05009 1.000 24.14142 ? 461  THR A N   1 
ATOM   3959 C CA  . THR A  1 462 ? -23.82860 9.68671   -10.34847 1.000 24.88641 ? 461  THR A CA  1 
ATOM   3960 C C   . THR A  1 462 ? -22.85155 9.94601   -9.21000  1.000 27.57323 ? 461  THR A C   1 
ATOM   3961 O O   . THR A  1 462 ? -22.39210 11.07539  -9.01810  1.000 29.47222 ? 461  THR A O   1 
ATOM   3962 C CB  . THR A  1 462 ? -23.24734 10.14167  -11.68590 1.000 26.94637 ? 461  THR A CB  1 
ATOM   3963 O OG1 . THR A  1 462 ? -23.12388 11.57280  -11.69360 1.000 27.19806 ? 461  THR A OG1 1 
ATOM   3964 C CG2 . THR A  1 462 ? -24.14100 9.69927   -12.81828 1.000 25.22181 ? 461  THR A CG2 1 
ATOM   3965 N N   . TYR A  1 463 ? -22.52442 8.90111   -8.45933  1.000 21.73109 ? 462  TYR A N   1 
ATOM   3966 C CA  . TYR A  1 463 ? -21.73018 9.04706   -7.25008  1.000 23.79543 ? 462  TYR A CA  1 
ATOM   3967 C C   . TYR A  1 463 ? -20.26727 8.73175   -7.52764  1.000 23.00693 ? 462  TYR A C   1 
ATOM   3968 O O   . TYR A  1 463 ? -19.94164 7.64944   -8.02539  1.000 22.89115 ? 462  TYR A O   1 
ATOM   3969 C CB  . TYR A  1 463 ? -22.27036 8.14192   -6.13920  1.000 22.78598 ? 462  TYR A CB  1 
ATOM   3970 C CG  . TYR A  1 463 ? -23.62549 8.58437   -5.62752  1.000 20.90089 ? 462  TYR A CG  1 
ATOM   3971 C CD1 . TYR A  1 463 ? -23.72426 9.57673   -4.66554  1.000 22.91301 ? 462  TYR A CD1 1 
ATOM   3972 C CD2 . TYR A  1 463 ? -24.79916 8.01111   -6.10948  1.000 22.89771 ? 462  TYR A CD2 1 
ATOM   3973 C CE1 . TYR A  1 463 ? -24.96106 9.99036   -4.18753  1.000 25.33463 ? 462  TYR A CE1 1 
ATOM   3974 C CE2 . TYR A  1 463 ? -26.04481 8.41669   -5.63159  1.000 24.94892 ? 462  TYR A CE2 1 
ATOM   3975 C CZ  . TYR A  1 463 ? -26.11300 9.40441   -4.67637  1.000 25.93417 ? 462  TYR A CZ  1 
ATOM   3976 O OH  . TYR A  1 463 ? -27.34491 9.81480   -4.20060  1.000 31.92221 ? 462  TYR A OH  1 
ATOM   3977 N N   . ALA A  1 464 ? -19.39238 9.66830   -7.17972  1.000 23.00087 ? 463  ALA A N   1 
ATOM   3978 C CA  . ALA A  1 464 ? -17.95812 9.44854   -7.28977  1.000 23.91840 ? 463  ALA A CA  1 
ATOM   3979 C C   . ALA A  1 464 ? -17.48296 8.46296   -6.22325  1.000 25.26541 ? 463  ALA A C   1 
ATOM   3980 O O   . ALA A  1 464 ? -18.18891 8.16666   -5.25442  1.000 23.17610 ? 463  ALA A O   1 
ATOM   3981 C CB  . ALA A  1 464 ? -17.20101 10.76860  -7.13835  1.000 28.35631 ? 463  ALA A CB  1 
ATOM   3982 N N   A GLN A  1 465 ? -16.26202 7.96195   -6.41429  0.536 25.64971 ? 464  GLN A N   1 
ATOM   3983 N N   B GLN A  1 465 ? -16.26039 7.96093   -6.41188  0.464 25.65503 ? 464  GLN A N   1 
ATOM   3984 C CA  A GLN A  1 465 ? -15.64546 7.06890   -5.43840  0.536 24.06269 ? 464  GLN A CA  1 
ATOM   3985 C CA  B GLN A  1 465 ? -15.65448 7.06040   -5.43560  0.464 24.06190 ? 464  GLN A CA  1 
ATOM   3986 C C   A GLN A  1 465 ? -15.59679 7.72420   -4.06459  0.536 26.66053 ? 464  GLN A C   1 
ATOM   3987 C C   B GLN A  1 465 ? -15.59292 7.71892   -4.06518  0.464 26.65520 ? 464  GLN A C   1 
ATOM   3988 O O   A GLN A  1 465 ? -15.19460 8.88283   -3.92869  0.536 27.72972 ? 464  GLN A O   1 
ATOM   3989 O O   B GLN A  1 465 ? -15.17616 8.87310   -3.93268  0.464 27.71739 ? 464  GLN A O   1 
ATOM   3990 C CB  A GLN A  1 465 ? -14.23321 6.69341   -5.89277  0.536 23.61443 ? 464  GLN A CB  1 
ATOM   3991 C CB  B GLN A  1 465 ? -14.24709 6.65121   -5.88021  0.464 23.66846 ? 464  GLN A CB  1 
ATOM   3992 C CG  A GLN A  1 465 ? -13.40659 5.95253   -4.83872  0.536 24.60667 ? 464  GLN A CG  1 
ATOM   3993 C CG  B GLN A  1 465 ? -13.62279 5.54959   -5.00710  0.464 25.13645 ? 464  GLN A CG  1 
ATOM   3994 C CD  A GLN A  1 465 ? -12.10963 5.40328   -5.40411  0.536 35.75815 ? 464  GLN A CD  1 
ATOM   3995 C CD  B GLN A  1 465 ? -12.24462 5.11763   -5.48505  0.464 35.91408 ? 464  GLN A CD  1 
ATOM   3996 O OE1 A GLN A  1 465 ? -11.54549 5.96262   -6.34774  0.536 37.76166 ? 464  GLN A OE1 1 
ATOM   3997 O OE1 B GLN A  1 465 ? -12.10501 4.14127   -6.23087  0.464 31.46755 ? 464  GLN A OE1 1 
ATOM   3998 N NE2 A GLN A  1 465 ? -11.62614 4.30627   -4.82852  0.536 31.70610 ? 464  GLN A NE2 1 
ATOM   3999 N NE2 B GLN A  1 465 ? -11.21512 5.83134   -5.03959  0.464 36.06316 ? 464  GLN A NE2 1 
ATOM   4000 N N   . GLY A  1 466 ? -16.01008 6.97866   -3.04193  1.000 23.40870 ? 465  GLY A N   1 
ATOM   4001 C CA  . GLY A  1 466 ? -15.95945 7.47030   -1.68607  1.000 23.95510 ? 465  GLY A CA  1 
ATOM   4002 C C   . GLY A  1 466 ? -17.19316 8.21131   -1.22572  1.000 21.84855 ? 465  GLY A C   1 
ATOM   4003 O O   . GLY A  1 466 ? -17.25814 8.59077   -0.04731  1.000 27.28432 ? 465  GLY A O   1 
ATOM   4004 N N   . ALA A  1 467 ? -18.17354 8.42466   -2.10434  1.000 23.61590 ? 466  ALA A N   1 
ATOM   4005 C CA  . ALA A  1 467 ? -19.39404 9.11381   -1.70697  1.000 25.86093 ? 466  ALA A CA  1 
ATOM   4006 C C   . ALA A  1 467 ? -20.16338 8.28951   -0.68364  1.000 28.76236 ? 466  ALA A C   1 
ATOM   4007 O O   . ALA A  1 467 ? -20.18220 7.05972   -0.73885  1.000 23.33981 ? 466  ALA A O   1 
ATOM   4008 C CB  . ALA A  1 467 ? -20.28149 9.38356   -2.91973  1.000 25.25368 ? 466  ALA A CB  1 
ATOM   4009 N N   . LEU A  1 468 ? -20.81540 8.98681   0.24761   1.000 25.70693 ? 467  LEU A N   1 
ATOM   4010 C CA  . LEU A  1 468 ? -21.58357 8.37634   1.32757   1.000 28.28412 ? 467  LEU A CA  1 
ATOM   4011 C C   . LEU A  1 468 ? -23.05657 8.73403   1.18834   1.000 29.24926 ? 467  LEU A C   1 
ATOM   4012 O O   . LEU A  1 468 ? -23.39845 9.90630   1.00152   1.000 28.74768 ? 467  LEU A O   1 
ATOM   4013 C CB  . LEU A  1 468 ? -21.07632 8.84360   2.69275   1.000 28.45653 ? 467  LEU A CB  1 
ATOM   4014 C CG  . LEU A  1 468 ? -19.66547 8.42093   3.09307   1.000 33.37329 ? 467  LEU A CG  1 
ATOM   4015 C CD1 . LEU A  1 468 ? -19.14435 9.29836   4.22541   1.000 37.23875 ? 467  LEU A CD1 1 
ATOM   4016 C CD2 . LEU A  1 468 ? -19.68330 6.96300   3.51680   1.000 31.00835 ? 467  LEU A CD2 1 
ATOM   4017 N N   . VAL A  1 469 ? -23.93047 7.72813   1.28314   1.000 25.32542 ? 468  VAL A N   1 
ATOM   4018 C CA  . VAL A  1 469 ? -25.37293 7.93567   1.24356   1.000 26.84937 ? 468  VAL A CA  1 
ATOM   4019 C C   . VAL A  1 469 ? -26.02620 7.08070   2.31893   1.000 34.13042 ? 468  VAL A C   1 
ATOM   4020 O O   . VAL A  1 469 ? -25.47293 6.07808   2.77642   1.000 28.88876 ? 468  VAL A O   1 
ATOM   4021 C CB  . VAL A  1 469 ? -26.01063 7.60435   -0.12091  1.000 27.85870 ? 468  VAL A CB  1 
ATOM   4022 C CG1 . VAL A  1 469 ? -25.28318 8.32707   -1.24599  1.000 28.23865 ? 468  VAL A CG1 1 
ATOM   4023 C CG2 . VAL A  1 469 ? -26.02588 6.09040   -0.35800  1.000 25.39296 ? 468  VAL A CG2 1 
ATOM   4024 N N   . SER A  1 470 ? -27.22425 7.48663   2.71587   1.000 30.40119 ? 469  SER A N   1 
ATOM   4025 C CA  . SER A  1 470 ? -28.04492 6.67894   3.60202   1.000 30.57746 ? 469  SER A CA  1 
ATOM   4026 C C   . SER A  1 470 ? -29.12460 5.99553   2.78021   1.000 33.08776 ? 469  SER A C   1 
ATOM   4027 O O   . SER A  1 470 ? -29.69189 6.58766   1.85576   1.000 34.98939 ? 469  SER A O   1 
ATOM   4028 C CB  . SER A  1 470 ? -28.65587 7.53098   4.72100   1.000 36.18062 ? 469  SER A CB  1 
ATOM   4029 O OG  . SER A  1 470 ? -29.67730 8.37147   4.22243   1.000 42.76268 ? 469  SER A OG  1 
ATOM   4030 N N   . TYR A  1 471 ? -29.38264 4.73059   3.09009   1.000 27.37313 ? 470  TYR A N   1 
ATOM   4031 C CA  . TYR A  1 471 ? -30.34700 3.97192   2.30801   1.000 28.51600 ? 470  TYR A CA  1 
ATOM   4032 C C   . TYR A  1 471 ? -30.78962 2.75318   3.09907   1.000 39.07349 ? 470  TYR A C   1 
ATOM   4033 O O   . TYR A  1 471 ? -29.94825 1.96580   3.54165   1.000 31.51210 ? 470  TYR A O   1 
ATOM   4034 C CB  . TYR A  1 471 ? -29.74886 3.53286   0.97036   1.000 28.35303 ? 470  TYR A CB  1 
ATOM   4035 C CG  . TYR A  1 471 ? -30.73870 2.92967   0.01029   1.000 28.81889 ? 470  TYR A CG  1 
ATOM   4036 C CD1 . TYR A  1 471 ? -31.78468 3.68395   -0.50072  1.000 33.93911 ? 470  TYR A CD1 1 
ATOM   4037 C CD2 . TYR A  1 471 ? -30.61797 1.61220   -0.40946  1.000 29.64103 ? 470  TYR A CD2 1 
ATOM   4038 C CE1 . TYR A  1 471 ? -32.68881 3.13972   -1.39482  1.000 30.07333 ? 470  TYR A CE1 1 
ATOM   4039 C CE2 . TYR A  1 471 ? -31.51924 1.05712   -1.30372  1.000 34.05924 ? 470  TYR A CE2 1 
ATOM   4040 C CZ  . TYR A  1 471 ? -32.55375 1.83157   -1.79227  1.000 35.39909 ? 470  TYR A CZ  1 
ATOM   4041 O OH  . TYR A  1 471 ? -33.45084 1.29940   -2.68532  1.000 36.47905 ? 470  TYR A OH  1 
ATOM   4042 N N   . GLN A  1 472 ? -32.10522 2.60245   3.25630   1.000 33.19110 ? 471  GLN A N   1 
ATOM   4043 C CA  . GLN A  1 472 ? -32.71807 1.41019   3.84417   1.000 40.54252 ? 471  GLN A CA  1 
ATOM   4044 C C   . GLN A  1 472 ? -32.02897 0.99454   5.14167   1.000 35.06543 ? 471  GLN A C   1 
ATOM   4045 O O   . GLN A  1 472 ? -31.69282 -0.17269  5.35143   1.000 37.57588 ? 471  GLN A O   1 
ATOM   4046 C CB  . GLN A  1 472 ? -32.73463 0.26362   2.83474   1.000 31.01391 ? 471  GLN A CB  1 
ATOM   4047 C CG  . GLN A  1 472 ? -33.69233 0.49279   1.68368   1.000 35.62200 ? 471  GLN A CG  1 
ATOM   4048 C CD  . GLN A  1 472 ? -33.73430 -0.66419  0.71790   1.000 44.29825 ? 471  GLN A CD  1 
ATOM   4049 O OE1 . GLN A  1 472 ? -32.89505 -1.56620  0.76980   1.000 48.15947 ? 471  GLN A OE1 1 
ATOM   4050 N NE2 . GLN A  1 472 ? -34.71900 -0.64989  -0.17696  1.000 48.64273 ? 471  GLN A NE2 1 
ATOM   4051 N N   . GLY A  1 473 ? -31.80546 1.97559   6.01525   1.000 34.64069 ? 472  GLY A N   1 
ATOM   4052 C CA  . GLY A  1 473 ? -31.34426 1.73394   7.36525   1.000 35.66537 ? 472  GLY A CA  1 
ATOM   4053 C C   . GLY A  1 473 ? -29.85611 1.88626   7.58135   1.000 35.43706 ? 472  GLY A C   1 
ATOM   4054 O O   . GLY A  1 473 ? -29.41310 1.90051   8.73910   1.000 37.73589 ? 472  GLY A O   1 
ATOM   4055 N N   . TYR A  1 474 ? -29.06950 2.02450   6.51693   1.000 30.28363 ? 473  TYR A N   1 
ATOM   4056 C CA  . TYR A  1 474 ? -27.62203 2.01859   6.64563   1.000 31.37468 ? 473  TYR A CA  1 
ATOM   4057 C C   . TYR A  1 474 ? -27.00995 3.18593   5.88941   1.000 27.73652 ? 473  TYR A C   1 
ATOM   4058 O O   . TYR A  1 474 ? -27.65923 3.83207   5.06243   1.000 28.40685 ? 473  TYR A O   1 
ATOM   4059 C CB  . TYR A  1 474 ? -27.04107 0.68993   6.14664   1.000 30.24516 ? 473  TYR A CB  1 
ATOM   4060 C CG  . TYR A  1 474 ? -27.54609 -0.47515  6.96108   1.000 30.70924 ? 473  TYR A CG  1 
ATOM   4061 C CD1 . TYR A  1 474 ? -26.92386 -0.82619  8.14935   1.000 29.90284 ? 473  TYR A CD1 1 
ATOM   4062 C CD2 . TYR A  1 474 ? -28.65869 -1.20274  6.55647   1.000 30.17516 ? 473  TYR A CD2 1 
ATOM   4063 C CE1 . TYR A  1 474 ? -27.39109 -1.88657  8.91447   1.000 39.71280 ? 473  TYR A CE1 1 
ATOM   4064 C CE2 . TYR A  1 474 ? -29.13180 -2.26590  7.31150   1.000 40.05991 ? 473  TYR A CE2 1 
ATOM   4065 C CZ  . TYR A  1 474 ? -28.49207 -2.60246  8.48662   1.000 38.02148 ? 473  TYR A CZ  1 
ATOM   4066 O OH  . TYR A  1 474 ? -28.95540 -3.65964  9.24233   1.000 41.73657 ? 473  TYR A OH  1 
ATOM   4067 N N   . VAL A  1 475 ? -25.74582 3.45527   6.21272   1.000 27.11928 ? 474  VAL A N   1 
ATOM   4068 C CA  . VAL A  1 475 ? -24.90961 4.38167   5.46307   1.000 27.72630 ? 474  VAL A CA  1 
ATOM   4069 C C   . VAL A  1 475 ? -23.95423 3.56076   4.60820   1.000 28.78478 ? 474  VAL A C   1 
ATOM   4070 O O   . VAL A  1 475 ? -23.31081 2.62316   5.10107   1.000 24.53700 ? 474  VAL A O   1 
ATOM   4071 C CB  . VAL A  1 475 ? -24.15480 5.33368   6.40353   1.000 29.47995 ? 474  VAL A CB  1 
ATOM   4072 C CG1 . VAL A  1 475 ? -23.11087 6.14164   5.64248   1.000 29.18887 ? 474  VAL A CG1 1 
ATOM   4073 C CG2 . VAL A  1 475 ? -25.15112 6.26064   7.08837   1.000 26.01810 ? 474  VAL A CG2 1 
ATOM   4074 N N   . TRP A  1 476 ? -23.87076 3.90801   3.32885   1.000 24.51349 ? 475  TRP A N   1 
ATOM   4075 C CA  . TRP A  1 476 ? -23.12767 3.15450   2.33265   1.000 23.85582 ? 475  TRP A CA  1 
ATOM   4076 C C   . TRP A  1 476 ? -22.09524 4.05173   1.66382   1.000 32.75436 ? 475  TRP A C   1 
ATOM   4077 O O   . TRP A  1 476 ? -22.31188 5.25737   1.51287   1.000 25.82333 ? 475  TRP A O   1 
ATOM   4078 C CB  . TRP A  1 476 ? -24.05225 2.59416   1.26112   1.000 22.93329 ? 475  TRP A CB  1 
ATOM   4079 C CG  . TRP A  1 476 ? -25.23563 1.80885   1.74510   1.000 30.81167 ? 475  TRP A CG  1 
ATOM   4080 C CD1 . TRP A  1 476 ? -26.39042 2.29348   2.29324   1.000 26.76415 ? 475  TRP A CD1 1 
ATOM   4081 C CD2 . TRP A  1 476 ? -25.39298 0.39158   1.66892   1.000 27.37832 ? 475  TRP A CD2 1 
ATOM   4082 N NE1 . TRP A  1 476 ? -27.25913 1.25803   2.56201   1.000 26.97568 ? 475  TRP A NE1 1 
ATOM   4083 C CE2 . TRP A  1 476 ? -26.66682 0.07979   2.19306   1.000 27.08395 ? 475  TRP A CE2 1 
ATOM   4084 C CE3 . TRP A  1 476 ? -24.57810 -0.64699  1.20871   1.000 25.14178 ? 475  TRP A CE3 1 
ATOM   4085 C CZ2 . TRP A  1 476 ? -27.14304 -1.22484  2.26772   1.000 28.75186 ? 475  TRP A CZ2 1 
ATOM   4086 C CZ3 . TRP A  1 476 ? -25.05530 -1.94374  1.27805   1.000 27.73802 ? 475  TRP A CZ3 1 
ATOM   4087 C CH2 . TRP A  1 476 ? -26.32774 -2.22057  1.80388   1.000 24.65070 ? 475  TRP A CH2 1 
ATOM   4088 N N   . GLN A  1 477 ? -20.97762 3.45339   1.23992   1.000 21.61363 ? 476  GLN A N   1 
ATOM   4089 C CA  . GLN A  1 477 ? -19.91071 4.18367   0.56342   1.000 22.44242 ? 476  GLN A CA  1 
ATOM   4090 C C   . GLN A  1 477 ? -19.59701 3.53137   -0.77437  1.000 22.96894 ? 476  GLN A C   1 
ATOM   4091 O O   . GLN A  1 477 ? -19.51408 2.30452   -0.86120  1.000 21.61225 ? 476  GLN A O   1 
ATOM   4092 C CB  . GLN A  1 477 ? -18.64155 4.22464   1.42946   1.000 21.51480 ? 476  GLN A CB  1 
ATOM   4093 C CG  . GLN A  1 477 ? -17.56837 5.15104   0.88822   1.000 25.79819 ? 476  GLN A CG  1 
ATOM   4094 C CD  . GLN A  1 477 ? -16.48231 5.42347   1.89975   1.000 38.40612 ? 476  GLN A CD  1 
ATOM   4095 O OE1 . GLN A  1 477 ? -16.08403 4.53529   2.64367   1.000 34.48428 ? 476  GLN A OE1 1 
ATOM   4096 N NE2 . GLN A  1 477 ? -15.99513 6.65917   1.93221   1.000 37.13571 ? 476  GLN A NE2 1 
ATOM   4097 N N   . THR A  1 478 ? -19.42032 4.34239   -1.82260  1.000 19.85683 ? 477  THR A N   1 
ATOM   4098 C CA  . THR A  1 478 ? -19.04956 3.76604   -3.10977  1.000 18.47603 ? 477  THR A CA  1 
ATOM   4099 C C   . THR A  1 478 ? -17.60153 3.30410   -3.06513  1.000 19.26052 ? 477  THR A C   1 
ATOM   4100 O O   . THR A  1 478 ? -16.73087 3.98042   -2.50661  1.000 21.22584 ? 477  THR A O   1 
ATOM   4101 C CB  . THR A  1 478 ? -19.21957 4.77103   -4.25382  1.000 23.33502 ? 477  THR A CB  1 
ATOM   4102 O OG1 . THR A  1 478 ? -18.49240 5.96144   -3.94262  1.000 23.18798 ? 477  THR A OG1 1 
ATOM   4103 C CG2 . THR A  1 478 ? -20.68101 5.11322   -4.46992  1.000 22.70069 ? 477  THR A CG2 1 
ATOM   4104 N N   . LYS A  1 479 ? -17.34985 2.14057   -3.65852  1.000 18.67249 ? 478  LYS A N   1 
ATOM   4105 C CA  . LYS A  1 479 ? -15.99545 1.60350   -3.73990  1.000 19.90826 ? 478  LYS A CA  1 
ATOM   4106 C C   . LYS A  1 479 ? -15.22272 2.19924   -4.90682  1.000 24.78977 ? 478  LYS A C   1 
ATOM   4107 O O   . LYS A  1 479 ? -13.99001 2.27615   -4.86316  1.000 23.59315 ? 478  LYS A O   1 
ATOM   4108 C CB  . LYS A  1 479 ? -16.05216 0.08081   -3.87755  1.000 19.75741 ? 478  LYS A CB  1 
ATOM   4109 C CG  . LYS A  1 479 ? -16.73968 -0.62468  -2.71238  1.000 18.03914 ? 478  LYS A CG  1 
ATOM   4110 C CD  . LYS A  1 479 ? -17.02198 -2.08624  -3.04690  1.000 17.06765 ? 478  LYS A CD  1 
ATOM   4111 C CE  . LYS A  1 479 ? -17.88694 -2.73096  -1.95383  1.000 17.79949 ? 478  LYS A CE  1 
ATOM   4112 N NZ  . LYS A  1 479 ? -18.23587 -4.14942  -2.29238  1.000 18.95336 ? 478  LYS A NZ  1 
ATOM   4113 N N   . TRP A  1 480 ? -15.92916 2.58318   -5.96430  1.000 19.87946 ? 479  TRP A N   1 
ATOM   4114 C CA  . TRP A  1 480 ? -15.35239 3.28033   -7.10443  1.000 21.50837 ? 479  TRP A CA  1 
ATOM   4115 C C   . TRP A  1 480 ? -16.42024 4.24014   -7.61510  1.000 23.28038 ? 479  TRP A C   1 
ATOM   4116 O O   . TRP A  1 480 ? -17.50959 4.32989   -7.04789  1.000 23.37203 ? 479  TRP A O   1 
ATOM   4117 C CB  . TRP A  1 480 ? -14.86305 2.29107   -8.17908  1.000 20.36663 ? 479  TRP A CB  1 
ATOM   4118 C CG  . TRP A  1 480 ? -15.94003 1.49132   -8.86615  1.000 21.02509 ? 479  TRP A CG  1 
ATOM   4119 C CD1 . TRP A  1 480 ? -16.63191 1.84464   -9.99016  1.000 22.57750 ? 479  TRP A CD1 1 
ATOM   4120 C CD2 . TRP A  1 480 ? -16.42118 0.19014   -8.49214  1.000 20.36426 ? 479  TRP A CD2 1 
ATOM   4121 N NE1 . TRP A  1 480 ? -17.52389 0.85236   -10.32979 1.000 23.39867 ? 479  TRP A NE1 1 
ATOM   4122 C CE2 . TRP A  1 480 ? -17.41586 -0.17114  -9.42250  1.000 21.37135 ? 479  TRP A CE2 1 
ATOM   4123 C CE3 . TRP A  1 480 ? -16.11245 -0.69868  -7.45313  1.000 19.91505 ? 479  TRP A CE3 1 
ATOM   4124 C CZ2 . TRP A  1 480 ? -18.10234 -1.38728  -9.35461  1.000 24.19799 ? 479  TRP A CZ2 1 
ATOM   4125 C CZ3 . TRP A  1 480 ? -16.80096 -1.90901  -7.38339  1.000 20.21011 ? 479  TRP A CZ3 1 
ATOM   4126 C CH2 . TRP A  1 480 ? -17.78283 -2.23828  -8.32760  1.000 23.03785 ? 479  TRP A CH2 1 
ATOM   4127 N N   . GLY A  1 481 ? -16.10290 4.98085   -8.67833  1.000 22.48788 ? 480  GLY A N   1 
ATOM   4128 C CA  . GLY A  1 481 ? -17.08177 5.82381   -9.32911  1.000 24.17302 ? 480  GLY A CA  1 
ATOM   4129 C C   . GLY A  1 481 ? -16.98174 5.64037   -10.83085 1.000 27.70636 ? 480  GLY A C   1 
ATOM   4130 O O   . GLY A  1 481 ? -15.98739 5.12054   -11.33717 1.000 26.71216 ? 480  GLY A O   1 
ATOM   4131 N N   . TYR A  1 482 ? -18.03156 6.06465   -11.54839 1.000 28.85043 ? 481  TYR A N   1 
ATOM   4132 C CA  . TYR A  1 482 ? -19.25926 6.64103   -10.98446 1.000 24.38663 ? 481  TYR A CA  1 
ATOM   4133 C C   . TYR A  1 482 ? -20.33776 5.57927   -10.84667 1.000 26.72901 ? 481  TYR A C   1 
ATOM   4134 O O   . TYR A  1 482 ? -20.52361 4.75957   -11.74820 1.000 26.70703 ? 481  TYR A O   1 
ATOM   4135 C CB  . TYR A  1 482 ? -19.77907 7.79100   -11.86899 1.000 25.63954 ? 481  TYR A CB  1 
ATOM   4136 C CG  . TYR A  1 482 ? -18.82941 8.95805   -11.89453 1.000 26.31909 ? 481  TYR A CG  1 
ATOM   4137 C CD1 . TYR A  1 482 ? -18.75632 9.83750   -10.82465 1.000 26.81557 ? 481  TYR A CD1 1 
ATOM   4138 C CD2 . TYR A  1 482 ? -17.96722 9.15195   -12.96903 1.000 40.73521 ? 481  TYR A CD2 1 
ATOM   4139 C CE1 . TYR A  1 482 ? -17.85474 10.89451  -10.82229 1.000 27.59301 ? 481  TYR A CE1 1 
ATOM   4140 C CE2 . TYR A  1 482 ? -17.07296 10.20441  -12.98367 1.000 37.25742 ? 481  TYR A CE2 1 
ATOM   4141 C CZ  . TYR A  1 482 ? -17.01759 11.07063  -11.91342 1.000 37.36650 ? 481  TYR A CZ  1 
ATOM   4142 O OH  . TYR A  1 482 ? -16.11796 12.11504  -11.93166 1.000 37.28591 ? 481  TYR A OH  1 
ATOM   4143 N N   . ILE A  1 483 ? -21.06708 5.61196   -9.72897  1.000 23.62333 ? 482  ILE A N   1 
ATOM   4144 C CA  . ILE A  1 483 ? -22.06611 4.60146   -9.40367  1.000 22.61337 ? 482  ILE A CA  1 
ATOM   4145 C C   . ILE A  1 483 ? -23.44736 5.22709   -9.50196  1.000 20.43561 ? 482  ILE A C   1 
ATOM   4146 O O   . ILE A  1 483 ? -23.66810 6.32925   -8.98680  1.000 23.27534 ? 482  ILE A O   1 
ATOM   4147 C CB  . ILE A  1 483 ? -21.85367 4.04384   -7.98020  1.000 20.18492 ? 482  ILE A CB  1 
ATOM   4148 C CG1 . ILE A  1 483 ? -20.42572 3.51902   -7.80061  1.000 24.31847 ? 482  ILE A CG1 1 
ATOM   4149 C CG2 . ILE A  1 483 ? -22.88529 2.96652   -7.67126  1.000 23.02352 ? 482  ILE A CG2 1 
ATOM   4150 C CD1 . ILE A  1 483 ? -19.96329 2.61349   -8.92591  1.000 23.39593 ? 482  ILE A CD1 1 
ATOM   4151 N N   . THR A  1 484 ? -24.39494 4.49747   -10.09052 1.000 23.08818 ? 483  THR A N   1 
ATOM   4152 C CA  . THR A  1 484 ? -25.79427 4.90374   -10.01863 1.000 23.42271 ? 483  THR A CA  1 
ATOM   4153 C C   . THR A  1 484 ? -26.71152 3.85801   -9.40081  1.000 33.44936 ? 483  THR A C   1 
ATOM   4154 O O   . THR A  1 484 ? -27.90033 4.13854   -9.21903  1.000 33.53030 ? 483  THR A O   1 
ATOM   4155 C CB  . THR A  1 484 ? -26.33202 5.26570   -11.41204 1.000 24.10680 ? 483  THR A CB  1 
ATOM   4156 O OG1 . THR A  1 484 ? -26.15963 4.15254   -12.29455 1.000 27.66783 ? 483  THR A OG1 1 
ATOM   4157 C CG2 . THR A  1 484 ? -25.58477 6.47636   -11.96553 1.000 27.94190 ? 483  THR A CG2 1 
ATOM   4158 N N   . SER A  1 485 ? -26.20437 2.67422   -9.06813  1.000 27.62417 ? 484  SER A N   1 
ATOM   4159 C CA  . SER A  1 485 ? -27.05814 1.60623   -8.57020  1.000 27.42766 ? 484  SER A CA  1 
ATOM   4160 C C   . SER A  1 485 ? -27.57823 1.91325   -7.16625  1.000 25.60420 ? 484  SER A C   1 
ATOM   4161 O O   . SER A  1 485 ? -27.02147 2.72655   -6.42283  1.000 24.91351 ? 484  SER A O   1 
ATOM   4162 C CB  . SER A  1 485 ? -26.28676 0.29181   -8.55874  1.000 28.52681 ? 484  SER A CB  1 
ATOM   4163 O OG  . SER A  1 485 ? -25.18118 0.41293   -7.68447  1.000 25.90971 ? 484  SER A OG  1 
ATOM   4164 N N   . ALA A  1 486 ? -28.66866 1.24049   -6.79993  1.000 26.26903 ? 485  ALA A N   1 
ATOM   4165 C CA  . ALA A  1 486 ? -29.17393 1.37269   -5.44331  1.000 29.10301 ? 485  ALA A CA  1 
ATOM   4166 C C   . ALA A  1 486 ? -28.24928 0.62160   -4.49038  1.000 24.48141 ? 485  ALA A C   1 
ATOM   4167 O O   . ALA A  1 486 ? -27.83315 -0.50048  -4.79982  1.000 29.07149 ? 485  ALA A O   1 
ATOM   4168 C CB  . ALA A  1 486 ? -30.59565 0.82354   -5.32323  1.000 29.74999 ? 485  ALA A CB  1 
ATOM   4169 N N   . PRO A  1 487 ? -27.89113 1.22113   -3.35588  1.000 25.23171 ? 486  PRO A N   1 
ATOM   4170 C CA  . PRO A  1 487 ? -26.98388 0.55326   -2.41467  1.000 24.15142 ? 486  PRO A CA  1 
ATOM   4171 C C   . PRO A  1 487 ? -27.52477 -0.80633  -2.00045  1.000 29.39222 ? 486  PRO A C   1 
ATOM   4172 O O   . PRO A  1 487 ? -28.70503 -0.95097  -1.67373  1.000 29.63403 ? 486  PRO A O   1 
ATOM   4173 C CB  . PRO A  1 487 ? -26.92543 1.52455   -1.23372  1.000 24.49995 ? 486  PRO A CB  1 
ATOM   4174 C CG  . PRO A  1 487 ? -27.24254 2.86154   -1.84240  1.000 28.82622 ? 486  PRO A CG  1 
ATOM   4175 C CD  . PRO A  1 487 ? -28.25561 2.57230   -2.90179  1.000 24.36219 ? 486  PRO A CD  1 
ATOM   4176 N N   . GLY A  1 488 ? -26.64864 -1.80943  -2.03391  1.000 26.06938 ? 487  GLY A N   1 
ATOM   4177 C CA  . GLY A  1 488 ? -27.01856 -3.16706  -1.70539  1.000 31.84901 ? 487  GLY A CA  1 
ATOM   4178 C C   . GLY A  1 488 ? -27.48041 -4.01317  -2.86850  1.000 34.32024 ? 487  GLY A C   1 
ATOM   4179 O O   . GLY A  1 488 ? -27.63042 -5.22981  -2.70445  1.000 31.85620 ? 487  GLY A O   1 
ATOM   4180 N N   . SER A  1 489 ? -27.70544 -3.42258  -4.04311  1.000 28.99253 ? 488  SER A N   1 
ATOM   4181 C CA  . SER A  1 489 ? -28.19286 -4.17933  -5.18240  1.000 28.38563 ? 488  SER A CA  1 
ATOM   4182 C C   . SER A  1 489 ? -27.07747 -4.78965  -6.01836  1.000 26.84660 ? 488  SER A C   1 
ATOM   4183 O O   . SER A  1 489 ? -27.35840 -5.63084  -6.87499  1.000 28.99261 ? 488  SER A O   1 
ATOM   4184 C CB  . SER A  1 489 ? -29.06097 -3.28627  -6.07934  1.000 33.52878 ? 488  SER A CB  1 
ATOM   4185 O OG  . SER A  1 489 ? -28.26873 -2.29357  -6.71531  1.000 31.74744 ? 488  SER A OG  1 
ATOM   4186 N N   . ASP A  1 490 ? -25.83114 -4.38417  -5.80859  1.000 25.56971 ? 489  ASP A N   1 
ATOM   4187 C CA  . ASP A  1 490 ? -24.71714 -4.92688  -6.57819  1.000 24.53541 ? 489  ASP A CA  1 
ATOM   4188 C C   . ASP A  1 490 ? -23.46826 -4.81646  -5.71188  1.000 19.54252 ? 489  ASP A C   1 
ATOM   4189 O O   . ASP A  1 490 ? -23.56301 -4.65295  -4.49169  1.000 29.31769 ? 489  ASP A O   1 
ATOM   4190 C CB  . ASP A  1 490 ? -24.58887 -4.21570  -7.93970  1.000 24.22015 ? 489  ASP A CB  1 
ATOM   4191 C CG  . ASP A  1 490 ? -24.21644 -2.73577  -7.81404  1.000 24.86068 ? 489  ASP A CG  1 
ATOM   4192 O OD1 . ASP A  1 490 ? -23.94594 -2.24469  -6.70237  1.000 30.05854 ? 489  ASP A OD1 1 
ATOM   4193 O OD2 . ASP A  1 490 ? -24.20277 -2.05280  -8.85435  1.000 33.69775 ? 489  ASP A OD2 1 
ATOM   4194 N N   . SER A  1 491 ? -22.30129 -4.89157  -6.33335  1.000 20.07517 ? 490  SER A N   1 
ATOM   4195 C CA  . SER A  1 491 ? -21.05648 -4.94993  -5.57701  1.000 23.65928 ? 490  SER A CA  1 
ATOM   4196 C C   . SER A  1 491 ? -20.41848 -3.58709  -5.34738  1.000 24.07393 ? 490  SER A C   1 
ATOM   4197 O O   . SER A  1 491 ? -19.34259 -3.52021  -4.74720  1.000 21.65993 ? 490  SER A O   1 
ATOM   4198 C CB  . SER A  1 491 ? -20.05433 -5.85891  -6.29616  1.000 19.92077 ? 490  SER A CB  1 
ATOM   4199 O OG  . SER A  1 491 ? -19.64200 -5.27169  -7.52004  1.000 23.24841 ? 490  SER A OG  1 
ATOM   4200 N N   . ALA A  1 492 ? -21.03772 -2.50025  -5.81688  1.000 22.08800 ? 491  ALA A N   1 
ATOM   4201 C CA  . ALA A  1 492 ? -20.35310 -1.21066  -5.85778  1.000 18.09920 ? 491  ALA A CA  1 
ATOM   4202 C C   . ALA A  1 492 ? -20.36295 -0.47694  -4.52814  1.000 19.39587 ? 491  ALA A C   1 
ATOM   4203 O O   . ALA A  1 492 ? -19.52786 0.41259   -4.32982  1.000 19.66162 ? 491  ALA A O   1 
ATOM   4204 C CB  . ALA A  1 492 ? -20.99717 -0.29963  -6.90615  1.000 19.28240 ? 491  ALA A CB  1 
ATOM   4205 N N   . TRP A  1 493 ? -21.29034 -0.80549  -3.63037  1.000 20.93747 ? 492  TRP A N   1 
ATOM   4206 C CA  . TRP A  1 493 ? -21.47986 -0.06842  -2.38699  1.000 17.90377 ? 492  TRP A CA  1 
ATOM   4207 C C   . TRP A  1 493 ? -21.00754 -0.89062  -1.19767  1.000 21.72427 ? 492  TRP A C   1 
ATOM   4208 O O   . TRP A  1 493 ? -21.38755 -2.05657  -1.05756  1.000 23.80896 ? 492  TRP A O   1 
ATOM   4209 C CB  . TRP A  1 493 ? -22.95206 0.28807   -2.16649  1.000 20.78156 ? 492  TRP A CB  1 
ATOM   4210 C CG  . TRP A  1 493 ? -23.53726 1.26849   -3.14585  1.000 21.74113 ? 492  TRP A CG  1 
ATOM   4211 C CD1 . TRP A  1 493 ? -24.18287 0.97374   -4.30727  1.000 25.77014 ? 492  TRP A CD1 1 
ATOM   4212 C CD2 . TRP A  1 493 ? -23.55953 2.69957   -3.02240  1.000 21.28145 ? 492  TRP A CD2 1 
ATOM   4213 N NE1 . TRP A  1 493 ? -24.60373 2.13143   -4.91788  1.000 22.03565 ? 492  TRP A NE1 1 
ATOM   4214 C CE2 . TRP A  1 493 ? -24.23573 3.20304   -4.15240  1.000 21.96558 ? 492  TRP A CE2 1 
ATOM   4215 C CE3 . TRP A  1 493 ? -23.07985 3.59936   -2.06171  1.000 22.78279 ? 492  TRP A CE3 1 
ATOM   4216 C CZ2 . TRP A  1 493 ? -24.44360 4.56912   -4.35520  1.000 23.28132 ? 492  TRP A CZ2 1 
ATOM   4217 C CZ3 . TRP A  1 493 ? -23.28319 4.96033   -2.26156  1.000 26.65939 ? 492  TRP A CZ3 1 
ATOM   4218 C CH2 . TRP A  1 493 ? -23.95643 5.43058   -3.40624  1.000 23.95051 ? 492  TRP A CH2 1 
ATOM   4219 N N   . LEU A  1 494 ? -20.22848 -0.25973  -0.32663  1.000 20.36653 ? 493  LEU A N   1 
ATOM   4220 C CA  . LEU A  1 494 ? -19.81432 -0.83826  0.94671   1.000 21.70027 ? 493  LEU A CA  1 
ATOM   4221 C C   . LEU A  1 494 ? -20.71667 -0.33143  2.06456   1.000 24.57537 ? 493  LEU A C   1 
ATOM   4222 O O   . LEU A  1 494 ? -20.85074 0.88046   2.25554   1.000 23.74610 ? 493  LEU A O   1 
ATOM   4223 C CB  . LEU A  1 494 ? -18.36074 -0.46852  1.23862   1.000 21.11435 ? 493  LEU A CB  1 
ATOM   4224 C CG  . LEU A  1 494 ? -17.66234 -1.15128  2.40650   1.000 25.03932 ? 493  LEU A CG  1 
ATOM   4225 C CD1 . LEU A  1 494 ? -17.60966 -2.65688  2.18185   1.000 23.91773 ? 493  LEU A CD1 1 
ATOM   4226 C CD2 . LEU A  1 494 ? -16.26793 -0.57623  2.53409   1.000 25.38102 ? 493  LEU A CD2 1 
ATOM   4227 N N   . LYS A  1 495 ? -21.32156 -1.25340  2.81098   1.000 20.95972 ? 494  LYS A N   1 
ATOM   4228 C CA  . LYS A  1 495 ? -22.07202 -0.86829  4.00309   1.000 26.97038 ? 494  LYS A CA  1 
ATOM   4229 C C   . LYS A  1 495 ? -21.08899 -0.46980  5.09809   1.000 28.94169 ? 494  LYS A C   1 
ATOM   4230 O O   . LYS A  1 495 ? -20.37653 -1.32288  5.63481   1.000 27.67815 ? 494  LYS A O   1 
ATOM   4231 C CB  . LYS A  1 495 ? -22.96426 -2.01824  4.45890   1.000 24.09202 ? 494  LYS A CB  1 
ATOM   4232 C CG  . LYS A  1 495 ? -23.83724 -1.67040  5.66565   1.000 28.68327 ? 494  LYS A CG  1 
ATOM   4233 C CD  . LYS A  1 495 ? -24.63104 -2.87725  6.15699   1.000 28.98789 ? 494  LYS A CD  1 
ATOM   4234 C CE  . LYS A  1 495 ? -25.80801 -3.18275  5.24981   1.000 28.99268 ? 494  LYS A CE  1 
ATOM   4235 N NZ  . LYS A  1 495 ? -26.56176 -4.40290  5.68147   1.000 31.48689 ? 494  LYS A NZ  1 
ATOM   4236 N N   . VAL A  1 496 ? -21.02935 0.82020   5.43073   1.000 23.11260 ? 495  VAL A N   1 
ATOM   4237 C CA  . VAL A  1 496 ? -20.02043 1.31437   6.36032   1.000 23.15144 ? 495  VAL A CA  1 
ATOM   4238 C C   . VAL A  1 496 ? -20.59897 1.74633   7.70387   1.000 26.31764 ? 495  VAL A C   1 
ATOM   4239 O O   . VAL A  1 496 ? -19.83579 1.84757   8.67623   1.000 30.09743 ? 495  VAL A O   1 
ATOM   4240 C CB  . VAL A  1 496 ? -19.19002 2.46362   5.75032   1.000 28.10135 ? 495  VAL A CB  1 
ATOM   4241 C CG1 . VAL A  1 496 ? -18.35058 1.95378   4.57673   1.000 24.92426 ? 495  VAL A CG1 1 
ATOM   4242 C CG2 . VAL A  1 496 ? -20.08852 3.62548   5.31041   1.000 26.21301 ? 495  VAL A CG2 1 
ATOM   4243 N N   . GLY A  1 497 ? -21.90019 2.00234   7.79725   1.000 25.17415 ? 496  GLY A N   1 
ATOM   4244 C CA  . GLY A  1 497 ? -22.46430 2.42589   9.06777   1.000 27.40313 ? 496  GLY A CA  1 
ATOM   4245 C C   . GLY A  1 497 ? -23.94288 2.12403   9.14902   1.000 23.83534 ? 496  GLY A C   1 
ATOM   4246 O O   . GLY A  1 497 ? -24.57767 1.70622   8.17815   1.000 25.94558 ? 496  GLY A O   1 
ATOM   4247 N N   . ARG A  1 498 ? -24.49056 2.32640   10.34892  1.000 27.14074 ? 497  ARG A N   1 
ATOM   4248 C CA  . ARG A  1 498 ? -25.91129 2.13577   10.60142  1.000 30.70183 ? 497  ARG A CA  1 
ATOM   4249 C C   . ARG A  1 498 ? -26.53377 3.46870   10.99271  1.000 29.96698 ? 497  ARG A C   1 
ATOM   4250 O O   . ARG A  1 498 ? -25.87911 4.32280   11.59520  1.000 34.18369 ? 497  ARG A O   1 
ATOM   4251 C CB  . ARG A  1 498 ? -26.16142 1.10753   11.72647  1.000 29.83934 ? 497  ARG A CB  1 
ATOM   4252 C CG  . ARG A  1 498 ? -25.23499 1.27727   12.91521  1.000 43.47208 ? 497  ARG A CG  1 
ATOM   4253 C CD  . ARG A  1 498 ? -25.42553 0.17487   13.95283  1.000 47.13969 ? 497  ARG A CD  1 
ATOM   4254 N NE  . ARG A  1 498 ? -24.71518 0.48152   15.19043  1.000 54.70381 ? 497  ARG A NE  1 
ATOM   4255 C CZ  . ARG A  1 498 ? -25.30106 0.79051   16.34097  1.000 62.31129 ? 497  ARG A CZ  1 
ATOM   4256 N NH1 . ARG A  1 498 ? -26.61945 0.83922   16.45545  1.000 55.72265 ? 497  ARG A NH1 1 
ATOM   4257 N NH2 . ARG A  1 498 ? -24.54453 1.06227   17.40241  1.000 56.28766 ? 497  ARG A NH2 1 
ATOM   4258 N N   . LEU A  1 499 ? -27.80164 3.63787   10.64436  1.000 33.40257 ? 498  LEU A N   1 
ATOM   4259 C CA  . LEU A  1 499 ? -28.51857 4.85955   10.98590  1.000 33.63724 ? 498  LEU A CA  1 
ATOM   4260 C C   . LEU A  1 499 ? -29.00279 4.77583   12.42725  1.000 40.72532 ? 498  LEU A C   1 
ATOM   4261 O O   . LEU A  1 499 ? -29.53585 3.74280   12.82888  1.000 40.98031 ? 498  LEU A O   1 
ATOM   4262 C CB  . LEU A  1 499 ? -29.69943 5.07523   10.04288  1.000 36.32099 ? 498  LEU A CB  1 
ATOM   4263 C CG  . LEU A  1 499 ? -29.33928 5.50291   8.61558   1.000 32.05473 ? 498  LEU A CG  1 
ATOM   4264 C CD1 . LEU A  1 499 ? -30.54269 5.35620   7.69933   0.988 41.62138 ? 498  LEU A CD1 1 
ATOM   4265 C CD2 . LEU A  1 499 ? -28.79129 6.91634   8.59629   1.000 33.44435 ? 498  LEU A CD2 1 
HETATM 4266 C C1  . GOL B  2 .   ? -2.74991  -32.30616 36.40459  0.807 41.55843 ? 601  GOL A C1  1 
HETATM 4267 O O1  . GOL B  2 .   ? -1.77569  -31.85070 37.29743  0.807 21.18816 ? 601  GOL A O1  1 
HETATM 4268 C C2  . GOL B  2 .   ? -3.89713  -31.26728 36.33859  0.807 30.38881 ? 601  GOL A C2  1 
HETATM 4269 O O2  . GOL B  2 .   ? -4.84771  -31.61345 35.42366  0.807 31.39528 ? 601  GOL A O2  1 
HETATM 4270 C C3  . GOL B  2 .   ? -4.53309  -31.25152 37.75278  0.807 34.64417 ? 601  GOL A C3  1 
HETATM 4271 O O3  . GOL B  2 .   ? -5.28744  -30.08520 37.81002  0.807 19.06421 ? 601  GOL A O3  1 
HETATM 4272 C C1  . GOL C  2 .   ? 1.43594   -14.96300 20.66116  0.914 29.69802 ? 602  GOL A C1  1 
HETATM 4273 O O1  . GOL C  2 .   ? 2.46776   -14.90064 21.63616  0.914 19.82492 ? 602  GOL A O1  1 
HETATM 4274 C C2  . GOL C  2 .   ? 2.09257   -14.86583 19.27871  0.914 32.64658 ? 602  GOL A C2  1 
HETATM 4275 O O2  . GOL C  2 .   ? 3.07461   -15.82138 19.09043  0.914 31.47486 ? 602  GOL A O2  1 
HETATM 4276 C C3  . GOL C  2 .   ? 0.91699   -14.94538 18.22321  0.914 36.45107 ? 602  GOL A C3  1 
HETATM 4277 O O3  . GOL C  2 .   ? 0.25995   -16.22213 18.28305  0.914 26.39150 ? 602  GOL A O3  1 
HETATM 4278 C C1  . GOL D  2 .   ? -26.89199 -17.43522 27.87399  1.000 34.60535 ? 603  GOL A C1  1 
HETATM 4279 O O1  . GOL D  2 .   ? -27.15410 -18.36787 28.87549  1.000 43.30010 ? 603  GOL A O1  1 
HETATM 4280 C C2  . GOL D  2 .   ? -27.58295 -17.95865 26.60417  1.000 33.67659 ? 603  GOL A C2  1 
HETATM 4281 O O2  . GOL D  2 .   ? -27.26374 -17.18065 25.49180  1.000 29.90305 ? 603  GOL A O2  1 
HETATM 4282 C C3  . GOL D  2 .   ? -27.12179 -19.43728 26.48113  1.000 35.07084 ? 603  GOL A C3  1 
HETATM 4283 O O3  . GOL D  2 .   ? -27.67203 -19.97033 25.29851  1.000 36.89097 ? 603  GOL A O3  1 
HETATM 4284 C C   . ACT E  3 .   ? -5.68302  -20.74734 30.12506  1.000 25.26656 ? 604  ACT A C   1 
HETATM 4285 O O   . ACT E  3 .   ? -5.31957  -21.84939 29.62147  1.000 26.37494 ? 604  ACT A O   1 
HETATM 4286 O OXT . ACT E  3 .   ? -4.99460  -19.69361 30.32743  1.000 20.30063 ? 604  ACT A OXT 1 
HETATM 4287 C CH3 . ACT E  3 .   ? -7.16564  -20.65882 30.55841  1.000 25.42442 ? 604  ACT A CH3 1 
HETATM 4288 C C1  . GOL F  2 .   ? -3.36995  -0.46155  13.77932  0.817 41.33220 ? 605  GOL A C1  1 
HETATM 4289 O O1  . GOL F  2 .   ? -2.04909  -0.42232  13.34771  0.817 33.65020 ? 605  GOL A O1  1 
HETATM 4290 C C2  . GOL F  2 .   ? -3.64492  -1.94866  13.98053  0.817 34.81205 ? 605  GOL A C2  1 
HETATM 4291 O O2  . GOL F  2 .   ? -3.15602  -2.40039  15.18053  0.817 17.87611 ? 605  GOL A O2  1 
HETATM 4292 C C3  . GOL F  2 .   ? -5.16708  -2.19061  13.80741  0.817 30.28748 ? 605  GOL A C3  1 
HETATM 4293 O O3  . GOL F  2 .   ? -5.75245  -1.09640  13.19320  0.817 27.42385 ? 605  GOL A O3  1 
HETATM 4294 C C1  . GOL G  2 .   ? 16.41985  -16.79759 42.42666  0.889 33.81866 ? 606  GOL A C1  1 
HETATM 4295 O O1  . GOL G  2 .   ? 17.12046  -17.12104 41.29322  0.889 32.50118 ? 606  GOL A O1  1 
HETATM 4296 C C2  . GOL G  2 .   ? 17.39688  -16.11703 43.38291  0.889 37.29775 ? 606  GOL A C2  1 
HETATM 4297 O O2  . GOL G  2 .   ? 18.05756  -15.03467 42.78458  0.889 32.86836 ? 606  GOL A O2  1 
HETATM 4298 C C3  . GOL G  2 .   ? 16.48342  -15.66487 44.53176  0.889 35.19664 ? 606  GOL A C3  1 
HETATM 4299 O O3  . GOL G  2 .   ? 17.20386  -14.69956 45.23556  0.889 51.53411 ? 606  GOL A O3  1 
HETATM 4300 C C1  . GOL H  2 .   ? -3.53988  -4.45283  3.81835   0.952 40.79871 ? 607  GOL A C1  1 
HETATM 4301 O O1  . GOL H  2 .   ? -3.65890  -3.62441  2.69444   0.952 59.30211 ? 607  GOL A O1  1 
HETATM 4302 C C2  . GOL H  2 .   ? -4.69245  -4.06080  4.70470   0.952 35.64798 ? 607  GOL A C2  1 
HETATM 4303 O O2  . GOL H  2 .   ? -4.28497  -3.56503  5.94679   0.952 35.38183 ? 607  GOL A O2  1 
HETATM 4304 C C3  . GOL H  2 .   ? -5.69821  -5.27411  4.71098   0.952 30.86318 ? 607  GOL A C3  1 
HETATM 4305 O O3  . GOL H  2 .   ? -5.12632  -6.37160  5.35337   0.952 23.30972 ? 607  GOL A O3  1 
HETATM 4306 C C   . ACT I  3 .   ? -26.81063 -15.30921 37.19039  0.913 49.67572 ? 608  ACT A C   1 
HETATM 4307 O O   . ACT I  3 .   ? -27.04398 -15.88251 36.08012  0.913 35.30609 ? 608  ACT A O   1 
HETATM 4308 O OXT . ACT I  3 .   ? -25.72116 -14.83839 37.63220  0.913 43.47051 ? 608  ACT A OXT 1 
HETATM 4309 C CH3 . ACT I  3 .   ? -28.02342 -15.15122 38.16480  0.913 50.09779 ? 608  ACT A CH3 1 
HETATM 4310 P P   . PO4 J  4 .   ? -17.05411 -24.14132 6.22849   0.570 44.32630 ? 609  PO4 A P   1 
HETATM 4311 O O1  . PO4 J  4 .   ? -16.93288 -24.60567 4.79523   0.570 46.35554 ? 609  PO4 A O1  1 
HETATM 4312 O O2  . PO4 J  4 .   ? -17.09749 -25.35003 7.14195   0.570 25.65333 ? 609  PO4 A O2  1 
HETATM 4313 O O3  . PO4 J  4 .   ? -18.32792 -23.34480 6.38701   0.570 50.70390 ? 609  PO4 A O3  1 
HETATM 4314 O O4  . PO4 J  4 .   ? -15.87178 -23.26179 6.56549   0.570 31.03426 ? 609  PO4 A O4  1 
HETATM 4315 C C1  . GOL K  2 .   ? -0.42596  -10.54686 55.28678  0.768 34.61244 ? 610  GOL A C1  1 
HETATM 4316 O O1  . GOL K  2 .   ? -0.85630  -9.60432  54.37005  0.768 33.44525 ? 610  GOL A O1  1 
HETATM 4317 C C2  . GOL K  2 .   ? -1.20830  -10.30093 56.57078  0.768 36.66027 ? 610  GOL A C2  1 
HETATM 4318 O O2  . GOL K  2 .   ? -2.56691  -10.32120 56.34751  0.768 44.66549 ? 610  GOL A O2  1 
HETATM 4319 C C3  . GOL K  2 .   ? -0.75960  -11.43610 57.50379  0.768 30.35525 ? 610  GOL A C3  1 
HETATM 4320 O O3  . GOL K  2 .   ? -1.54918  -11.37082 58.59829  0.768 23.09979 ? 610  GOL A O3  1 
HETATM 4321 C C1  . GOL L  2 .   ? -28.78669 -25.62760 22.54193  0.802 19.71653 ? 611  GOL A C1  1 
HETATM 4322 O O1  . GOL L  2 .   ? -28.20940 -24.48831 21.97538  0.802 47.95473 ? 611  GOL A O1  1 
HETATM 4323 C C2  . GOL L  2 .   ? -30.12584 -25.14055 23.26155  0.802 34.27553 ? 611  GOL A C2  1 
HETATM 4324 O O2  . GOL L  2 .   ? -30.52515 -25.90960 24.33777  0.802 20.68317 ? 611  GOL A O2  1 
HETATM 4325 C C3  . GOL L  2 .   ? -29.91801 -23.66750 23.62252  0.802 22.99252 ? 611  GOL A C3  1 
HETATM 4326 O O3  . GOL L  2 .   ? -30.91122 -23.31186 24.50598  0.802 35.43559 ? 611  GOL A O3  1 
HETATM 4327 C C1  . GOL M  2 .   ? -17.00443 6.02163   37.83497  0.823 32.79181 ? 612  GOL A C1  1 
HETATM 4328 O O1  . GOL M  2 .   ? -16.48805 6.81939   36.81553  0.823 36.96701 ? 612  GOL A O1  1 
HETATM 4329 C C2  . GOL M  2 .   ? -17.33776 4.60015   37.27820  0.823 42.58864 ? 612  GOL A C2  1 
HETATM 4330 O O2  . GOL M  2 .   ? -16.65688 4.26854   36.10153  0.823 32.49693 ? 612  GOL A O2  1 
HETATM 4331 C C3  . GOL M  2 .   ? -16.99896 3.66190   38.43588  0.823 37.97032 ? 612  GOL A C3  1 
HETATM 4332 O O3  . GOL M  2 .   ? -17.45116 2.38369   38.11140  0.823 34.41837 ? 612  GOL A O3  1 
HETATM 4333 P P   . PO4 N  4 .   ? -7.81944  4.95703   43.31215  0.809 62.17229 ? 613  PO4 A P   1 
HETATM 4334 O O1  . PO4 N  4 .   ? -7.41964  5.39865   41.92480  0.809 52.86761 ? 613  PO4 A O1  1 
HETATM 4335 O O2  . PO4 N  4 .   ? -6.69409  5.29044   44.26382  0.809 66.72164 ? 613  PO4 A O2  1 
HETATM 4336 O O3  . PO4 N  4 .   ? -8.08254  3.46367   43.32913  0.809 35.96834 ? 613  PO4 A O3  1 
HETATM 4337 O O4  . PO4 N  4 .   ? -9.06772  5.70831   43.72385  0.809 48.56527 ? 613  PO4 A O4  1 
HETATM 4338 C C1  . GOL O  2 .   ? 6.15747   5.08426   26.68914  0.718 31.07705 ? 614  GOL A C1  1 
HETATM 4339 O O1  . GOL O  2 .   ? 5.39901   5.59098   27.75074  0.718 26.46972 ? 614  GOL A O1  1 
HETATM 4340 C C2  . GOL O  2 .   ? 5.48310   5.54853   25.36358  0.718 36.24113 ? 614  GOL A C2  1 
HETATM 4341 O O2  . GOL O  2 .   ? 4.95760   6.84565   25.45087  0.718 40.86051 ? 614  GOL A O2  1 
HETATM 4342 C C3  . GOL O  2 .   ? 6.57830   5.44712   24.28861  0.718 39.63814 ? 614  GOL A C3  1 
HETATM 4343 O O3  . GOL O  2 .   ? 6.10007   6.13812   23.16759  0.718 41.88868 ? 614  GOL A O3  1 
HETATM 4344 C C1  . GOL P  2 .   ? -14.02978 8.68400   -12.25482 0.722 39.87562 ? 615  GOL A C1  1 
HETATM 4345 O O1  . GOL P  2 .   ? -13.09541 7.96800   -12.98771 0.722 47.73290 ? 615  GOL A O1  1 
HETATM 4346 C C2  . GOL P  2 .   ? -14.12060 7.99749   -10.87586 0.722 44.38731 ? 615  GOL A C2  1 
HETATM 4347 O O2  . GOL P  2 .   ? -12.86810 7.74728   -10.32890 0.722 51.02386 ? 615  GOL A O2  1 
HETATM 4348 C C3  . GOL P  2 .   ? -14.97639 8.95576   -9.99680  0.722 40.97193 ? 615  GOL A C3  1 
HETATM 4349 O O3  . GOL P  2 .   ? -14.70472 8.65535   -8.65118  0.722 24.54652 ? 615  GOL A O3  1 
HETATM 4350 C C1  . GOL Q  2 .   ? 3.03781   -21.02050 22.39990  0.791 36.97204 ? 616  GOL A C1  1 
HETATM 4351 O O1  . GOL Q  2 .   ? 3.87789   -21.81426 21.61382  0.791 47.43302 ? 616  GOL A O1  1 
HETATM 4352 C C2  . GOL Q  2 .   ? 2.13661   -20.19876 21.43386  0.791 26.75719 ? 616  GOL A C2  1 
HETATM 4353 O O2  . GOL Q  2 .   ? 1.58496   -19.09166 22.04134  0.791 49.84098 ? 616  GOL A O2  1 
HETATM 4354 C C3  . GOL Q  2 .   ? 3.05382   -19.83435 20.24539  0.791 41.75493 ? 616  GOL A C3  1 
HETATM 4355 O O3  . GOL Q  2 .   ? 2.33867   -18.99862 19.37164  0.791 42.47149 ? 616  GOL A O3  1 
HETATM 4356 P P   . PO4 R  4 .   ? -24.36111 -6.11927  21.25151  0.577 40.51384 ? 617  PO4 A P   1 
HETATM 4357 O O1  . PO4 R  4 .   ? -24.65087 -6.72352  19.89391  0.577 42.37401 ? 617  PO4 A O1  1 
HETATM 4358 O O2  . PO4 R  4 .   ? -22.87097 -6.06674  21.46875  0.577 22.69674 ? 617  PO4 A O2  1 
HETATM 4359 O O3  . PO4 R  4 .   ? -25.03353 -6.94895  22.31208  0.577 35.94388 ? 617  PO4 A O3  1 
HETATM 4360 O O4  . PO4 R  4 .   ? -24.90175 -4.71112  21.30275  0.577 54.00647 ? 617  PO4 A O4  1 
HETATM 4361 C C1  . GOL S  2 .   ? -18.35687 -32.64494 11.02942  0.631 32.49507 ? 618  GOL A C1  1 
HETATM 4362 O O1  . GOL S  2 .   ? -17.28762 -31.75695 11.09260  0.631 33.61509 ? 618  GOL A O1  1 
HETATM 4363 C C2  . GOL S  2 .   ? -19.48390 -32.06336 11.89235  0.631 38.76644 ? 618  GOL A C2  1 
HETATM 4364 O O2  . GOL S  2 .   ? -20.71326 -32.15980 11.26490  0.631 47.96820 ? 618  GOL A O2  1 
HETATM 4365 C C3  . GOL S  2 .   ? -19.44088 -32.89053 13.17297  0.631 24.20459 ? 618  GOL A C3  1 
HETATM 4366 O O3  . GOL S  2 .   ? -20.03182 -34.11847 12.87230  0.631 34.18796 ? 618  GOL A O3  1 
HETATM 4367 C C1  . GOL T  2 .   ? 6.54800   -20.42471 29.15993  0.781 44.31661 ? 619  GOL A C1  1 
HETATM 4368 O O1  . GOL T  2 .   ? 7.87339   -20.13364 28.84431  0.781 35.15360 ? 619  GOL A O1  1 
HETATM 4369 C C2  . GOL T  2 .   ? 6.50932   -21.56782 30.20629  0.781 47.16135 ? 619  GOL A C2  1 
HETATM 4370 O O2  . GOL T  2 .   ? 7.27837   -21.28467 31.32589  0.781 43.28517 ? 619  GOL A O2  1 
HETATM 4371 C C3  . GOL T  2 .   ? 5.00979   -21.71472 30.57038  0.781 50.55189 ? 619  GOL A C3  1 
HETATM 4372 O O3  . GOL T  2 .   ? 4.28272   -20.97447 29.62018  0.781 47.01217 ? 619  GOL A O3  1 
HETATM 4373 C C1  . GOL U  2 .   ? -10.82005 3.99714   24.62541  0.728 37.82249 ? 620  GOL A C1  1 
HETATM 4374 O O1  . GOL U  2 .   ? -10.53269 5.32605   24.31914  0.728 37.29225 ? 620  GOL A O1  1 
HETATM 4375 C C2  . GOL U  2 .   ? -11.52210 3.41328   23.36360  0.728 42.34170 ? 620  GOL A C2  1 
HETATM 4376 O O2  . GOL U  2 .   ? -10.66938 3.34944   22.26539  0.728 31.13349 ? 620  GOL A O2  1 
HETATM 4377 C C3  . GOL U  2 .   ? -12.02625 2.02485   23.79952  0.728 35.85742 ? 620  GOL A C3  1 
HETATM 4378 O O3  . GOL U  2 .   ? -13.22050 2.22087   24.51187  0.728 32.97159 ? 620  GOL A O3  1 
HETATM 4379 C C1  . GOL V  2 .   ? 3.23807   -1.68379  42.25807  0.687 43.82594 ? 621  GOL A C1  1 
HETATM 4380 O O1  . GOL V  2 .   ? 2.72304   -0.95665  41.17320  0.687 36.35250 ? 621  GOL A O1  1 
HETATM 4381 C C2  . GOL V  2 .   ? 4.19883   -2.74609  41.66465  0.687 38.72561 ? 621  GOL A C2  1 
HETATM 4382 O O2  . GOL V  2 .   ? 4.58661   -3.70877  42.59327  0.687 43.73582 ? 621  GOL A O2  1 
HETATM 4383 C C3  . GOL V  2 .   ? 3.43246   -3.35091  40.50267  0.687 30.03550 ? 621  GOL A C3  1 
HETATM 4384 O O3  . GOL V  2 .   ? 3.85339   -2.68508  39.38204  0.687 20.70527 ? 621  GOL A O3  1 
HETATM 4385 P P   . PO4 W  4 .   ? -12.94207 9.27460   28.36465  0.592 54.77850 ? 622  PO4 A P   1 
HETATM 4386 O O1  . PO4 W  4 .   ? -13.94613 8.98969   27.27099  0.592 49.39541 ? 622  PO4 A O1  1 
HETATM 4387 O O2  . PO4 W  4 .   ? -11.71515 8.41931   28.14088  0.592 47.79628 ? 622  PO4 A O2  1 
HETATM 4388 O O3  . PO4 W  4 .   ? -13.57310 8.96781   29.70189  0.592 42.20365 ? 622  PO4 A O3  1 
HETATM 4389 O O4  . PO4 W  4 .   ? -12.54046 10.73226  28.33527  0.592 61.59348 ? 622  PO4 A O4  1 
HETATM 4390 C C1  . GOL X  2 .   ? -25.79938 -23.88543 45.84706  0.696 44.12569 ? 623  GOL A C1  1 
HETATM 4391 O O1  . GOL X  2 .   ? -25.69581 -22.88565 44.87562  0.696 31.53016 ? 623  GOL A O1  1 
HETATM 4392 C C2  . GOL X  2 .   ? -27.29877 -24.06390 46.16161  0.696 50.23486 ? 623  GOL A C2  1 
HETATM 4393 O O2  . GOL X  2 .   ? -28.09588 -23.48155 45.19314  0.696 49.28953 ? 623  GOL A O2  1 
HETATM 4394 C C3  . GOL X  2 .   ? -27.52192 -25.59865 46.26663  0.696 51.31919 ? 623  GOL A C3  1 
HETATM 4395 O O3  . GOL X  2 .   ? -26.26975 -26.21947 46.27155  0.696 54.27648 ? 623  GOL A O3  1 
HETATM 4396 C C1  . GOL Y  2 .   ? 4.67636   -28.86312 43.23227  0.811 49.99476 ? 624  GOL A C1  1 
HETATM 4397 O O1  . GOL Y  2 .   ? 3.41150   -29.22794 42.69365  0.811 39.20120 ? 624  GOL A O1  1 
HETATM 4398 C C2  . GOL Y  2 .   ? 4.48354   -28.29777 44.68629  0.811 54.41442 ? 624  GOL A C2  1 
HETATM 4399 O O2  . GOL Y  2 .   ? 5.20539   -27.10466 44.89489  0.811 41.64831 ? 624  GOL A O2  1 
HETATM 4400 C C3  . GOL Y  2 .   ? 4.97009   -29.43993 45.63188  0.811 47.15843 ? 624  GOL A C3  1 
HETATM 4401 O O3  . GOL Y  2 .   ? 3.84349   -30.15928 46.06769  0.811 38.59397 ? 624  GOL A O3  1 
HETATM 4402 C C1  . GOL Z  2 .   ? -18.70224 -13.62948 55.21497  0.951 50.10582 ? 625  GOL A C1  1 
HETATM 4403 O O1  . GOL Z  2 .   ? -18.35599 -12.51284 55.98212  0.951 53.76555 ? 625  GOL A O1  1 
HETATM 4404 C C2  . GOL Z  2 .   ? -20.16995 -14.02716 55.53341  0.951 45.56742 ? 625  GOL A C2  1 
HETATM 4405 O O2  . GOL Z  2 .   ? -20.40152 -14.10646 56.90344  0.951 63.45232 ? 625  GOL A O2  1 
HETATM 4406 C C3  . GOL Z  2 .   ? -21.04643 -12.97051 54.85856  0.951 43.41126 ? 625  GOL A C3  1 
HETATM 4407 O O3  . GOL Z  2 .   ? -22.13887 -13.64780 54.32311  0.951 61.11464 ? 625  GOL A O3  1 
HETATM 4408 C C1  . GOL AA 2 .   ? -4.63517  -37.06419 32.67455  0.733 36.73783 ? 626  GOL A C1  1 
HETATM 4409 O O1  . GOL AA 2 .   ? -5.86751  -37.12382 31.98680  0.733 27.86480 ? 626  GOL A O1  1 
HETATM 4410 C C2  . GOL AA 2 .   ? -3.47280  -37.23137 31.62383  0.733 41.53011 ? 626  GOL A C2  1 
HETATM 4411 O O2  . GOL AA 2 .   ? -3.71745  -38.24568 30.71779  0.733 45.93575 ? 626  GOL A O2  1 
HETATM 4412 C C3  . GOL AA 2 .   ? -2.19365  -37.50004 32.47731  0.733 43.72914 ? 626  GOL A C3  1 
HETATM 4413 O O3  . GOL AA 2 .   ? -1.21199  -36.59374 32.05061  0.733 45.88439 ? 626  GOL A O3  1 
HETATM 4414 C C1  . GOL BA 2 .   ? -1.60919  -19.10570 30.79735  0.841 38.76511 ? 627  GOL A C1  1 
HETATM 4415 O O1  . GOL BA 2 .   ? -2.49337  -20.07034 31.31709  0.841 36.26178 ? 627  GOL A O1  1 
HETATM 4416 C C2  . GOL BA 2 .   ? -0.20824  -19.75726 30.82401  0.841 46.46924 ? 627  GOL A C2  1 
HETATM 4417 O O2  . GOL BA 2 .   ? 0.59757   -19.28102 29.82861  0.841 37.33286 ? 627  GOL A O2  1 
HETATM 4418 C C3  . GOL BA 2 .   ? 0.36202   -19.44297 32.22046  0.841 41.26330 ? 627  GOL A C3  1 
HETATM 4419 O O3  . GOL BA 2 .   ? 1.30097   -20.43910 32.53034  0.841 41.79628 ? 627  GOL A O3  1 
HETATM 4420 C C1  . GOL CA 2 .   ? 2.25361   -21.89208 27.54181  0.841 40.65677 ? 628  GOL A C1  1 
HETATM 4421 O O1  . GOL CA 2 .   ? 3.08192   -22.15726 26.44607  0.841 48.67984 ? 628  GOL A O1  1 
HETATM 4422 C C2  . GOL CA 2 .   ? 0.80171   -21.95220 27.03687  0.841 43.34336 ? 628  GOL A C2  1 
HETATM 4423 O O2  . GOL CA 2 .   ? -0.09952  -21.36864 27.93464  0.841 47.45703 ? 628  GOL A O2  1 
HETATM 4424 C C3  . GOL CA 2 .   ? 0.83090   -21.25954 25.64720  0.841 45.17818 ? 628  GOL A C3  1 
HETATM 4425 O O3  . GOL CA 2 .   ? 0.76415   -19.88236 25.87332  0.841 39.46964 ? 628  GOL A O3  1 
HETATM 4426 C C1  . GOL DA 2 .   ? -21.48466 -32.39754 47.44721  0.615 43.32014 ? 629  GOL A C1  1 
HETATM 4427 O O1  . GOL DA 2 .   ? -20.42602 -32.64264 48.32860  0.615 45.31263 ? 629  GOL A O1  1 
HETATM 4428 C C2  . GOL DA 2 .   ? -21.12131 -33.04529 46.08380  0.615 32.06218 ? 629  GOL A C2  1 
HETATM 4429 O O2  . GOL DA 2 .   ? -20.74685 -34.37877 46.22157  0.615 33.98430 ? 629  GOL A O2  1 
HETATM 4430 C C3  . GOL DA 2 .   ? -22.38873 -32.88006 45.20387  0.615 37.17031 ? 629  GOL A C3  1 
HETATM 4431 O O3  . GOL DA 2 .   ? -23.01805 -31.68998 45.60442  0.615 41.46607 ? 629  GOL A O3  1 
HETATM 4432 C C1  . GOL EA 2 .   ? -5.75532  -21.41236 11.09816  0.733 27.81257 ? 630  GOL A C1  1 
HETATM 4433 O O1  . GOL EA 2 .   ? -4.80387  -21.11543 10.08577  0.733 48.79860 ? 630  GOL A O1  1 
HETATM 4434 C C2  . GOL EA 2 .   ? -6.81883  -22.37584 10.44085  0.733 32.87641 ? 630  GOL A C2  1 
HETATM 4435 O O2  . GOL EA 2 .   ? -6.91452  -22.21666 9.02975   0.733 39.60615 ? 630  GOL A O2  1 
HETATM 4436 C C3  . GOL EA 2 .   ? -6.34226  -23.79600 10.82701  0.733 34.11484 ? 630  GOL A C3  1 
HETATM 4437 O O3  . GOL EA 2 .   ? -7.44350  -24.49536 11.28955  0.733 31.37448 ? 630  GOL A O3  1 
HETATM 4438 C C1  . GOL FA 2 .   ? -1.68064  -22.94583 13.71217  0.771 47.47609 ? 631  GOL A C1  1 
HETATM 4439 O O1  . GOL FA 2 .   ? -1.09232  -22.54146 14.90891  0.771 39.90732 ? 631  GOL A O1  1 
HETATM 4440 C C2  . GOL FA 2 .   ? -2.82644  -21.93943 13.41020  0.771 43.06189 ? 631  GOL A C2  1 
HETATM 4441 O O2  . GOL FA 2 .   ? -3.44769  -21.47746 14.55975  0.771 31.01880 ? 631  GOL A O2  1 
HETATM 4442 C C3  . GOL FA 2 .   ? -2.14231  -20.80404 12.62512  0.771 44.28246 ? 631  GOL A C3  1 
HETATM 4443 O O3  . GOL FA 2 .   ? -2.39491  -21.06402 11.27920  0.771 37.43582 ? 631  GOL A O3  1 
HETATM 4444 C C1  . GOL GA 2 .   ? -11.08162 -19.51269 -0.05782  0.696 30.80999 ? 632  GOL A C1  1 
HETATM 4445 O O1  . GOL GA 2 .   ? -10.56447 -19.87050 -1.31394  0.696 30.39846 ? 632  GOL A O1  1 
HETATM 4446 C C2  . GOL GA 2 .   ? -10.09213 -19.97167 1.01123   0.696 43.54487 ? 632  GOL A C2  1 
HETATM 4447 O O2  . GOL GA 2 .   ? -8.83216  -19.43033 0.80926   0.696 34.00484 ? 632  GOL A O2  1 
HETATM 4448 C C3  . GOL GA 2 .   ? -10.73720 -19.53718 2.36822   0.696 35.81004 ? 632  GOL A C3  1 
HETATM 4449 O O3  . GOL GA 2 .   ? -10.87648 -18.13459 2.34242   0.696 43.04485 ? 632  GOL A O3  1 
HETATM 4450 C C1  . GOL HA 2 .   ? -22.50934 -11.61891 37.01822  0.885 37.65898 ? 633  GOL A C1  1 
HETATM 4451 O O1  . GOL HA 2 .   ? -23.45842 -10.72459 36.50058  0.885 40.86694 ? 633  GOL A O1  1 
HETATM 4452 C C2  . GOL HA 2 .   ? -22.97047 -11.95198 38.45255  0.885 42.52718 ? 633  GOL A C2  1 
HETATM 4453 O O2  . GOL HA 2 .   ? -24.19181 -11.36340 38.73821  0.885 61.47321 ? 633  GOL A O2  1 
HETATM 4454 C C3  . GOL HA 2 .   ? -23.05108 -13.49448 38.55954  0.885 37.44566 ? 633  GOL A C3  1 
HETATM 4455 O O3  . GOL HA 2 .   ? -22.27895 -14.05853 37.54484  0.885 27.17746 ? 633  GOL A O3  1 
HETATM 4456 C C   . ACT IA 3 .   ? 8.85585   -19.38562 48.04790  0.760 46.17117 ? 634  ACT A C   1 
HETATM 4457 O O   . ACT IA 3 .   ? 9.43425   -18.63170 48.88266  0.760 46.41953 ? 634  ACT A O   1 
HETATM 4458 O OXT . ACT IA 3 .   ? 9.23703   -19.76826 46.91012  0.760 36.08932 ? 634  ACT A OXT 1 
HETATM 4459 C CH3 . ACT IA 3 .   ? 7.48459   -19.93003 48.46916  0.760 35.51476 ? 634  ACT A CH3 1 
HETATM 4460 C C   . ACT JA 3 .   ? -3.69685  7.53628   37.15701  0.714 46.17269 ? 635  ACT A C   1 
HETATM 4461 O O   . ACT JA 3 .   ? -2.95631  8.53411   36.92467  0.714 55.68080 ? 635  ACT A O   1 
HETATM 4462 O OXT . ACT JA 3 .   ? -4.75513  7.47157   37.84088  0.714 48.31729 ? 635  ACT A OXT 1 
HETATM 4463 C CH3 . ACT JA 3 .   ? -3.25734  6.19256   36.52068  0.714 41.73801 ? 635  ACT A CH3 1 
HETATM 4464 C C   . ACT KA 3 .   ? 15.84835  3.20263   31.51782  0.679 46.66637 ? 636  ACT A C   1 
HETATM 4465 O O   . ACT KA 3 .   ? 15.49098  3.35639   32.72550  0.679 44.20865 ? 636  ACT A O   1 
HETATM 4466 O OXT . ACT KA 3 .   ? 15.14347  2.88247   30.51494  0.679 44.20189 ? 636  ACT A OXT 1 
HETATM 4467 C CH3 . ACT KA 3 .   ? 17.36719  3.44375   31.21002  0.679 43.91021 ? 636  ACT A CH3 1 
HETATM 4468 C C   . ACT LA 3 .   ? 0.51519   -17.53816 52.64220  0.684 40.76409 ? 637  ACT A C   1 
HETATM 4469 O O   . ACT LA 3 .   ? -0.13363  -16.97266 51.72240  0.684 45.79560 ? 637  ACT A O   1 
HETATM 4470 O OXT . ACT LA 3 .   ? 1.73468   -17.86229 52.65530  0.684 39.42984 ? 637  ACT A OXT 1 
HETATM 4471 C CH3 . ACT LA 3 .   ? -0.28479  -17.88943 53.94790  0.684 44.68297 ? 637  ACT A CH3 1 
HETATM 4472 C C   . ACT MA 3 .   ? -9.62506  -29.07866 57.79719  1.000 66.01522 ? 638  ACT A C   1 
HETATM 4473 O O   . ACT MA 3 .   ? -10.47556 -28.19753 58.12546  1.000 66.11360 ? 638  ACT A O   1 
HETATM 4474 O OXT . ACT MA 3 .   ? -8.43365  -28.92246 57.39054  1.000 65.86137 ? 638  ACT A OXT 1 
HETATM 4475 C CH3 . ACT MA 3 .   ? -10.09609 -30.57031 57.89910  1.000 56.64742 ? 638  ACT A CH3 1 
HETATM 4476 C C   . ACT NA 3 .   ? -15.78587 -40.21395 33.83375  0.557 32.76134 ? 639  ACT A C   1 
HETATM 4477 O O   . ACT NA 3 .   ? -16.61057 -39.69838 33.04458  0.557 30.61790 ? 639  ACT A O   1 
HETATM 4478 O OXT . ACT NA 3 .   ? -14.86386 -39.65702 34.48187  0.557 37.27779 ? 639  ACT A OXT 1 
HETATM 4479 C CH3 . ACT NA 3 .   ? -15.92054 -41.75805 34.06791  0.557 44.01367 ? 639  ACT A CH3 1 
HETATM 4480 C C   . ACT OA 3 .   ? -19.53698 -43.11665 17.31397  0.746 36.52645 ? 640  ACT A C   1 
HETATM 4481 O O   . ACT OA 3 .   ? -18.68924 -42.19010 17.42477  0.746 28.88341 ? 640  ACT A O   1 
HETATM 4482 O OXT . ACT OA 3 .   ? -20.35369 -43.33658 16.36311  0.746 39.43293 ? 640  ACT A OXT 1 
HETATM 4483 C CH3 . ACT OA 3 .   ? -19.59985 -44.13661 18.50606  0.746 41.81670 ? 640  ACT A CH3 1 
HETATM 4484 C C   . ACT PA 3 .   ? -18.31116 -19.49949 3.54047   0.811 49.82234 ? 641  ACT A C   1 
HETATM 4485 O O   . ACT PA 3 .   ? -18.68285 -18.89720 4.58942   0.811 52.18411 ? 641  ACT A O   1 
HETATM 4486 O OXT . ACT PA 3 .   ? -17.73268 -19.02680 2.52117   0.811 50.74825 ? 641  ACT A OXT 1 
HETATM 4487 C CH3 . ACT PA 3 .   ? -18.59503 -21.04371 3.48497   0.811 50.75937 ? 641  ACT A CH3 1 
HETATM 4488 C C   . ACT QA 3 .   ? -20.79307 2.13627   40.99376  0.839 50.42701 ? 642  ACT A C   1 
HETATM 4489 O O   . ACT QA 3 .   ? -21.28860 1.79821   42.10451  0.839 54.26590 ? 642  ACT A O   1 
HETATM 4490 O OXT . ACT QA 3 .   ? -20.04911 1.46261   40.21882  0.839 49.31110 ? 642  ACT A OXT 1 
HETATM 4491 C CH3 . ACT QA 3 .   ? -21.13889 3.57751   40.49633  0.839 48.82788 ? 642  ACT A CH3 1 
HETATM 4492 C C   . ACT RA 3 .   ? 20.46406  1.09536   30.28950  0.793 46.34899 ? 643  ACT A C   1 
HETATM 4493 O O   . ACT RA 3 .   ? 20.44369  1.97420   31.19319  0.793 55.66202 ? 643  ACT A O   1 
HETATM 4494 O OXT . ACT RA 3 .   ? 21.00505  -0.04645  30.30675  0.793 49.29126 ? 643  ACT A OXT 1 
HETATM 4495 C CH3 . ACT RA 3 .   ? 19.72792  1.44957   28.97168  0.793 41.78967 ? 643  ACT A CH3 1 
HETATM 4496 C C   . ACT SA 3 .   ? -10.00649 0.45729   8.97685   0.716 46.34409 ? 644  ACT A C   1 
HETATM 4497 O O   . ACT SA 3 .   ? -11.12994 -0.07221  8.75656   0.716 31.83551 ? 644  ACT A O   1 
HETATM 4498 O OXT . ACT SA 3 .   ? -8.92153  -0.10249  9.31630   0.716 41.41754 ? 644  ACT A OXT 1 
HETATM 4499 C CH3 . ACT SA 3 .   ? -9.93000  2.01846   8.81463   0.716 48.91247 ? 644  ACT A CH3 1 
HETATM 4500 C C   . ACT TA 3 .   ? -22.69385 -27.75453 45.51858  0.771 35.74566 ? 645  ACT A C   1 
HETATM 4501 O O   . ACT TA 3 .   ? -23.87622 -28.01306 45.13959  0.771 48.41267 ? 645  ACT A O   1 
HETATM 4502 O OXT . ACT TA 3 .   ? -21.95620 -26.79194 45.18281  0.771 24.91300 ? 645  ACT A OXT 1 
HETATM 4503 C CH3 . ACT TA 3 .   ? -22.05393 -28.73913 46.56192  0.771 39.84044 ? 645  ACT A CH3 1 
HETATM 4504 C C   . ACT UA 3 .   ? -6.88552  -1.07754  6.23452   0.652 37.51302 ? 646  ACT A C   1 
HETATM 4505 O O   . ACT UA 3 .   ? -5.69053  -1.47710  6.33058   0.652 41.64071 ? 646  ACT A O   1 
HETATM 4506 O OXT . ACT UA 3 .   ? -7.89303  -1.42455  6.91451   0.652 29.03045 ? 646  ACT A OXT 1 
HETATM 4507 C CH3 . ACT UA 3 .   ? -7.16812  0.01137   5.12671   0.652 44.95407 ? 646  ACT A CH3 1 
HETATM 4508 C C1  . GOL VA 2 .   ? 6.15398   -18.62343 14.87269  0.767 44.72456 ? 647  GOL A C1  1 
HETATM 4509 O O1  . GOL VA 2 .   ? 5.92077   -17.31308 14.47957  0.767 36.61295 ? 647  GOL A O1  1 
HETATM 4510 C C2  . GOL VA 2 .   ? 6.14902   -18.61838 16.41746  0.767 55.21959 ? 647  GOL A C2  1 
HETATM 4511 O O2  . GOL VA 2 .   ? 7.35389   -18.19864 16.94803  0.767 52.87763 ? 647  GOL A O2  1 
HETATM 4512 C C3  . GOL VA 2 .   ? 5.81134   -20.05843 16.81437  0.767 55.03655 ? 647  GOL A C3  1 
HETATM 4513 O O3  . GOL VA 2 .   ? 4.98726   -19.94768 17.92063  0.767 32.42207 ? 647  GOL A O3  1 
HETATM 4514 C C1  . GOL WA 2 .   ? 3.22750   5.52528   36.77398  1.000 58.47689 ? 648  GOL A C1  1 
HETATM 4515 O O1  . GOL WA 2 .   ? 4.45494   4.84048   36.75802  1.000 56.47123 ? 648  GOL A O1  1 
HETATM 4516 C C2  . GOL WA 2 .   ? 2.14773   4.59564   36.16212  1.000 45.44123 ? 648  GOL A C2  1 
HETATM 4517 O O2  . GOL WA 2 .   ? 1.76264   3.55940   37.03598  1.000 33.90985 ? 648  GOL A O2  1 
HETATM 4518 C C3  . GOL WA 2 .   ? 0.98921   5.55103   35.77602  1.000 48.00525 ? 648  GOL A C3  1 
HETATM 4519 O O3  . GOL WA 2 .   ? -0.19634  4.85455   36.01234  1.000 52.67128 ? 648  GOL A O3  1 
HETATM 4520 C C1  . GOL XA 2 .   ? -18.64294 -4.00254  5.31751   0.731 28.62962 ? 649  GOL A C1  1 
HETATM 4521 O O1  . GOL XA 2 .   ? -19.52754 -4.78456  4.55328   0.731 32.14465 ? 649  GOL A O1  1 
HETATM 4522 C C2  . GOL XA 2 .   ? -19.07789 -4.24971  6.76397   0.731 33.26313 ? 649  GOL A C2  1 
HETATM 4523 O O2  . GOL XA 2 .   ? -20.44307 -4.05446  6.88668   0.731 34.03823 ? 649  GOL A O2  1 
HETATM 4524 C C3  . GOL XA 2 .   ? -18.20979 -3.29853  7.64096   0.731 27.33740 ? 649  GOL A C3  1 
HETATM 4525 O O3  . GOL XA 2 .   ? -18.34369 -1.99220  7.15876   0.731 29.30310 ? 649  GOL A O3  1 
HETATM 4526 C C1  . GOL YA 2 .   ? 1.31040   -18.10152 15.52982  1.000 51.55012 ? 650  GOL A C1  1 
HETATM 4527 O O1  . GOL YA 2 .   ? 1.38323   -18.64705 16.83708  1.000 47.61852 ? 650  GOL A O1  1 
HETATM 4528 C C2  . GOL YA 2 .   ? 2.73376   -17.65590 15.05213  1.000 47.65081 ? 650  GOL A C2  1 
HETATM 4529 O O2  . GOL YA 2 .   ? 2.78041   -17.42766 13.67854  1.000 55.93994 ? 650  GOL A O2  1 
HETATM 4530 C C3  . GOL YA 2 .   ? 3.05189   -16.36778 15.83983  1.000 43.88845 ? 650  GOL A C3  1 
HETATM 4531 O O3  . GOL YA 2 .   ? 4.13487   -15.73220 15.21766  1.000 41.56729 ? 650  GOL A O3  1 
HETATM 4532 C C1  . GOL ZA 2 .   ? -34.84000 -27.13008 28.64456  0.789 40.50353 ? 651  GOL A C1  1 
HETATM 4533 O O1  . GOL ZA 2 .   ? -35.90173 -26.54766 27.92503  0.789 45.20730 ? 651  GOL A O1  1 
HETATM 4534 C C2  . GOL ZA 2 .   ? -34.09004 -27.99784 27.60823  0.789 34.06782 ? 651  GOL A C2  1 
HETATM 4535 O O2  . GOL ZA 2 .   ? -33.93118 -27.28126 26.42279  0.789 37.29268 ? 651  GOL A O2  1 
HETATM 4536 C C3  . GOL ZA 2 .   ? -35.02567 -29.23503 27.42166  0.789 39.22886 ? 651  GOL A C3  1 
HETATM 4537 O O3  . GOL ZA 2 .   ? -34.27401 -30.27373 26.87012  0.789 19.40402 ? 651  GOL A O3  1 
HETATM 4538 C C1  . GOL AB 2 .   ? 26.10724  -18.09525 35.85852  0.689 34.12187 ? 652  GOL A C1  1 
HETATM 4539 O O1  . GOL AB 2 .   ? 26.74076  -18.75332 36.90376  0.689 33.46699 ? 652  GOL A O1  1 
HETATM 4540 C C2  . GOL AB 2 .   ? 24.75223  -17.67835 36.43790  0.689 40.93811 ? 652  GOL A C2  1 
HETATM 4541 O O2  . GOL AB 2 .   ? 24.89309  -16.69315 37.40325  0.689 47.84482 ? 652  GOL A O2  1 
HETATM 4542 C C3  . GOL AB 2 .   ? 23.90234  -17.21146 35.24797  0.689 33.63461 ? 652  GOL A C3  1 
HETATM 4543 O O3  . GOL AB 2 .   ? 22.71925  -16.71144 35.83224  0.689 32.51006 ? 652  GOL A O3  1 
HETATM 4544 C C1  . GOL BB 2 .   ? -19.34133 -15.46972 9.17685   0.703 30.93681 ? 653  GOL A C1  1 
HETATM 4545 O O1  . GOL BB 2 .   ? -18.58489 -16.45079 8.52474   0.703 35.26640 ? 653  GOL A O1  1 
HETATM 4546 C C2  . GOL BB 2 .   ? -19.54958 -14.32453 8.15548   0.703 35.06796 ? 653  GOL A C2  1 
HETATM 4547 O O2  . GOL BB 2 .   ? -19.57165 -14.82434 6.86687   0.703 37.82200 ? 653  GOL A O2  1 
HETATM 4548 C C3  . GOL BB 2 .   ? -20.90886 -13.68242 8.55496   0.703 46.08793 ? 653  GOL A C3  1 
HETATM 4549 O O3  . GOL BB 2 .   ? -20.75129 -12.28390 8.51577   0.703 39.14902 ? 653  GOL A O3  1 
HETATM 4550 C C1  . GOL CB 2 .   ? -18.74368 -5.87018  45.30172  0.798 29.28192 ? 654  GOL A C1  1 
HETATM 4551 O O1  . GOL CB 2 .   ? -17.87462 -6.79967  45.84394  0.798 34.00255 ? 654  GOL A O1  1 
HETATM 4552 C C2  . GOL CB 2 .   ? -20.06019 -6.62973  45.02132  0.798 41.56041 ? 654  GOL A C2  1 
HETATM 4553 O O2  . GOL CB 2 .   ? -20.61662 -7.18324  46.17733  0.798 54.74416 ? 654  GOL A O2  1 
HETATM 4554 C C3  . GOL CB 2 .   ? -20.97710 -5.59035  44.35365  0.798 36.96158 ? 654  GOL A C3  1 
HETATM 4555 O O3  . GOL CB 2 .   ? -21.94923 -6.30551  43.66180  0.798 48.45474 ? 654  GOL A O3  1 
HETATM 4556 C C   . ACT DB 3 .   ? -28.93529 7.18800   -18.28311 0.814 57.34512 ? 655  ACT A C   1 
HETATM 4557 O O   . ACT DB 3 .   ? -28.40754 7.28911   -19.43231 0.814 56.92356 ? 655  ACT A O   1 
HETATM 4558 O OXT . ACT DB 3 .   ? -30.12983 7.43179   -17.93531 0.814 52.77070 ? 655  ACT A OXT 1 
HETATM 4559 C CH3 . ACT DB 3 .   ? -27.99871 6.68969   -17.12743 0.814 54.13151 ? 655  ACT A CH3 1 
HETATM 4560 O O   . HOH EB 5 .   ? 19.899    -8.260    23.090    0.838 22.77899 ? 701  HOH A O   1 
HETATM 4561 O O   . HOH EB 5 .   ? -15.74101 -30.74185 12.62818  1.000 26.00609 ? 702  HOH A O   1 
HETATM 4562 O O   . HOH EB 5 .   ? -32.395   -25.708   26.201    1.000 34.02445 ? 703  HOH A O   1 
HETATM 4563 O O   . HOH EB 5 .   ? -13.048   6.574     -14.720   1.000 41.55464 ? 704  HOH A O   1 
HETATM 4564 O O   . HOH EB 5 .   ? -1.97343  1.23409   42.00258  1.000 44.33207 ? 705  HOH A O   1 
HETATM 4565 O O   . HOH EB 5 .   ? -6.36489  6.66037   39.14598  1.000 42.60474 ? 706  HOH A O   1 
HETATM 4566 O O   . HOH EB 5 .   ? -0.23283  -19.09873 23.35047  1.000 36.37283 ? 707  HOH A O   1 
HETATM 4567 O O   . HOH EB 5 .   ? -11.92652 -20.82861 -2.83189  1.000 54.44153 ? 708  HOH A O   1 
HETATM 4568 O O   . HOH EB 5 .   ? -22.23882 -34.60326 12.59586  1.000 37.66282 ? 709  HOH A O   1 
HETATM 4569 O O   . HOH EB 5 .   ? -2.43264  8.98871   28.72964  1.000 31.20706 ? 710  HOH A O   1 
HETATM 4570 O O   . HOH EB 5 .   ? 9.71118   -14.89639 47.99198  1.000 30.68814 ? 711  HOH A O   1 
HETATM 4571 O O   . HOH EB 5 .   ? 12.11602  4.08267   26.89447  1.000 51.71617 ? 712  HOH A O   1 
HETATM 4572 O O   . HOH EB 5 .   ? 5.36067   -0.58287  14.57810  1.000 48.64309 ? 713  HOH A O   1 
HETATM 4573 O O   . HOH EB 5 .   ? -2.69926  -35.43373 52.47956  1.000 43.30243 ? 714  HOH A O   1 
HETATM 4574 O O   . HOH EB 5 .   ? -23.56657 -15.67221 19.27093  1.000 32.23210 ? 715  HOH A O   1 
HETATM 4575 O O   . HOH EB 5 .   ? -4.92346  -20.61132 54.44388  1.000 42.47639 ? 716  HOH A O   1 
HETATM 4576 O O   . HOH EB 5 .   ? 2.84038   -17.65218 54.76629  1.000 35.07491 ? 717  HOH A O   1 
HETATM 4577 O O   . HOH EB 5 .   ? -38.010   -27.665   28.211    1.000 45.70324 ? 718  HOH A O   1 
HETATM 4578 O O   . HOH EB 5 .   ? -20.140   -43.195   13.952    1.000 54.09168 ? 719  HOH A O   1 
HETATM 4579 O O   . HOH EB 5 .   ? -9.42012  8.85830   27.44691  1.000 31.24082 ? 720  HOH A O   1 
HETATM 4580 O O   . HOH EB 5 .   ? 20.108    -19.439   27.555    1.000 22.61604 ? 721  HOH A O   1 
HETATM 4581 O O   . HOH EB 5 .   ? 20.29321  -11.92887 23.39459  1.000 28.57553 ? 722  HOH A O   1 
HETATM 4582 O O   . HOH EB 5 .   ? -18.36324 -34.93837 46.20758  1.000 26.59286 ? 723  HOH A O   1 
HETATM 4583 O O   . HOH EB 5 .   ? -24.31374 -7.26466  24.63686  1.000 22.96858 ? 724  HOH A O   1 
HETATM 4584 O O   . HOH EB 5 .   ? -15.63672 -27.49774 10.90321  1.000 18.69943 ? 725  HOH A O   1 
HETATM 4585 O O   . HOH EB 5 .   ? 15.99994  -12.73770 19.90321  1.000 23.91260 ? 726  HOH A O   1 
HETATM 4586 O O   . HOH EB 5 .   ? -17.13559 -6.95440  48.19623  1.000 48.34050 ? 727  HOH A O   1 
HETATM 4587 O O   . HOH EB 5 .   ? -0.49248  6.17109   31.04568  1.000 38.34538 ? 728  HOH A O   1 
HETATM 4588 O O   . HOH EB 5 .   ? 0.26471   -0.66136  41.00811  1.000 42.39387 ? 729  HOH A O   1 
HETATM 4589 O O   . HOH EB 5 .   ? -6.10550  -31.81165 15.08195  1.000 27.77093 ? 730  HOH A O   1 
HETATM 4590 O O   . HOH EB 5 .   ? -13.76044 -23.55026 7.84908   1.000 40.06139 ? 731  HOH A O   1 
HETATM 4591 O O   . HOH EB 5 .   ? 0.03505   -1.33524  14.38675  1.000 23.63406 ? 732  HOH A O   1 
HETATM 4592 O O   . HOH EB 5 .   ? -4.02343  -38.47147 28.24496  1.000 34.06608 ? 733  HOH A O   1 
HETATM 4593 O O   . HOH EB 5 .   ? 1.03486   -21.12464 16.68440  1.000 49.46323 ? 734  HOH A O   1 
HETATM 4594 O O   . HOH EB 5 .   ? -17.79021 -1.16141  21.05457  1.000 43.23758 ? 735  HOH A O   1 
HETATM 4595 O O   . HOH EB 5 .   ? -15.73564 6.65561   28.66929  1.000 45.86431 ? 736  HOH A O   1 
HETATM 4596 O O   . HOH EB 5 .   ? 1.92760   8.52449   24.94035  1.000 46.06511 ? 737  HOH A O   1 
HETATM 4597 O O   . HOH EB 5 .   ? -14.24168 -14.24168 0.00000   0.50  29.14867 ? 738  HOH A O   1 
HETATM 4598 O O   . HOH EB 5 .   ? -12.78326 -1.51590  15.69000  1.000 32.62383 ? 739  HOH A O   1 
HETATM 4599 O O   . HOH EB 5 .   ? -16.77975 -34.49010 12.80925  1.000 36.61200 ? 740  HOH A O   1 
HETATM 4600 O O   . HOH EB 5 .   ? -24.61004 -8.99233  18.78038  1.000 37.08096 ? 741  HOH A O   1 
HETATM 4601 O O   . HOH EB 5 .   ? -11.75063 -16.45905 21.29349  1.000 15.94767 ? 742  HOH A O   1 
HETATM 4602 O O   . HOH EB 5 .   ? -10.64670 11.70825  29.70707  1.000 54.09558 ? 743  HOH A O   1 
HETATM 4603 O O   . HOH EB 5 .   ? -16.29257 -20.65184 7.46296   1.000 27.47566 ? 744  HOH A O   1 
HETATM 4604 O O   . HOH EB 5 .   ? -20.08470 -11.53935 10.85040  1.000 24.68453 ? 745  HOH A O   1 
HETATM 4605 O O   . HOH EB 5 .   ? -14.40770 -24.17120 10.45650  1.000 22.31874 ? 746  HOH A O   1 
HETATM 4606 O O   . HOH EB 5 .   ? -6.94533  -12.75092 44.55272  1.000 27.18225 ? 747  HOH A O   1 
HETATM 4607 O O   . HOH EB 5 .   ? -16.40603 -1.85646  18.11681  1.000 29.23945 ? 748  HOH A O   1 
HETATM 4608 O O   . HOH EB 5 .   ? -3.45202  7.94185   32.38863  1.000 34.04724 ? 749  HOH A O   1 
HETATM 4609 O O   . HOH EB 5 .   ? 8.01888   3.07130   28.70605  1.000 39.30235 ? 750  HOH A O   1 
HETATM 4610 O O   . HOH EB 5 .   ? 15.13144  -2.52168  22.89369  1.000 31.89961 ? 751  HOH A O   1 
HETATM 4611 O O   . HOH EB 5 .   ? 16.93629  -27.44008 39.98595  1.000 40.58260 ? 752  HOH A O   1 
HETATM 4612 O O   . HOH EB 5 .   ? -5.44746  0.29217   10.96823  1.000 42.19836 ? 753  HOH A O   1 
HETATM 4613 O O   . HOH EB 5 .   ? 8.17641   -19.74476 37.04371  1.000 22.81507 ? 754  HOH A O   1 
HETATM 4614 O O   . HOH EB 5 .   ? 13.64974  -29.18207 27.82642  1.000 40.39062 ? 755  HOH A O   1 
HETATM 4615 O O   . HOH EB 5 .   ? 7.27610   -21.82085 26.50014  1.000 43.80510 ? 756  HOH A O   1 
HETATM 4616 O O   . HOH EB 5 .   ? -31.95830 7.18288   4.17648   1.000 50.67982 ? 757  HOH A O   1 
HETATM 4617 O O   . HOH EB 5 .   ? 15.290    -19.236   46.432    1.000 48.71032 ? 758  HOH A O   1 
HETATM 4618 O O   . HOH EB 5 .   ? 5.81004   -17.33505 40.33540  1.000 21.40416 ? 759  HOH A O   1 
HETATM 4619 O O   . HOH EB 5 .   ? -0.481    -22.418   10.203    1.000 30.37759 ? 760  HOH A O   1 
HETATM 4620 O O   . HOH EB 5 .   ? -11.83760 6.71332   26.20955  1.000 41.10306 ? 761  HOH A O   1 
HETATM 4621 O O   . HOH EB 5 .   ? 14.06809  -26.37470 42.64618  1.000 42.26956 ? 762  HOH A O   1 
HETATM 4622 O O   . HOH EB 5 .   ? -24.86504 -17.83196 49.64467  1.000 44.86721 ? 763  HOH A O   1 
HETATM 4623 O O   . HOH EB 5 .   ? -4.19474  -29.82727 15.79905  1.000 32.73514 ? 764  HOH A O   1 
HETATM 4624 O O   . HOH EB 5 .   ? 6.12861   4.89629   20.69947  1.000 39.69487 ? 765  HOH A O   1 
HETATM 4625 O O   . HOH EB 5 .   ? -23.09165 -3.71220  -2.08484  1.000 40.21569 ? 766  HOH A O   1 
HETATM 4626 O O   . HOH EB 5 .   ? -17.31224 2.24692   48.07960  1.000 50.92757 ? 767  HOH A O   1 
HETATM 4627 O O   . HOH EB 5 .   ? -2.58539  -20.31978 23.82582  1.000 29.03608 ? 768  HOH A O   1 
HETATM 4628 O O   . HOH EB 5 .   ? 8.08575   -11.77089 22.85483  1.000 24.09176 ? 769  HOH A O   1 
HETATM 4629 O O   . HOH EB 5 .   ? -10.69385 -14.55104 3.58127   1.000 16.95052 ? 770  HOH A O   1 
HETATM 4630 O O   . HOH EB 5 .   ? -25.50681 -35.65629 19.42402  1.000 19.26277 ? 771  HOH A O   1 
HETATM 4631 O O   . HOH EB 5 .   ? -21.29154 2.58005   -12.94015 1.000 43.90313 ? 772  HOH A O   1 
HETATM 4632 O O   . HOH EB 5 .   ? -8.95361  -9.56269  47.44239  1.000 23.83010 ? 773  HOH A O   1 
HETATM 4633 O O   . HOH EB 5 .   ? 7.627     -16.762   49.012    1.000 26.95493 ? 774  HOH A O   1 
HETATM 4634 O O   . HOH EB 5 .   ? -14.51927 -42.73607 31.36516  1.000 31.23844 ? 775  HOH A O   1 
HETATM 4635 O O   . HOH EB 5 .   ? -0.52306  -36.92485 37.42429  1.000 36.65722 ? 776  HOH A O   1 
HETATM 4636 O O   . HOH EB 5 .   ? -8.67438  -11.30959 52.39979  1.000 38.83669 ? 777  HOH A O   1 
HETATM 4637 O O   . HOH EB 5 .   ? 16.65347  1.76177   28.70833  1.000 38.39186 ? 778  HOH A O   1 
HETATM 4638 O O   . HOH EB 5 .   ? 21.76305  -19.70296 31.17127  1.000 19.53173 ? 779  HOH A O   1 
HETATM 4639 O O   . HOH EB 5 .   ? -0.62460  7.45091   25.43788  1.000 26.29613 ? 780  HOH A O   1 
HETATM 4640 O O   . HOH EB 5 .   ? -23.09828 -10.82660 32.74678  1.000 38.67184 ? 781  HOH A O   1 
HETATM 4641 O O   . HOH EB 5 .   ? -21.53068 -16.25838 39.10426  1.000 20.83459 ? 782  HOH A O   1 
HETATM 4642 O O   . HOH EB 5 .   ? 0.55573   -27.08234 15.96279  1.000 51.44427 ? 783  HOH A O   1 
HETATM 4643 O O   . HOH EB 5 .   ? -31.21552 -26.65431 44.07592  1.000 37.85504 ? 784  HOH A O   1 
HETATM 4644 O O   . HOH EB 5 .   ? -17.70252 -6.72845  -8.50594  1.000 19.41894 ? 785  HOH A O   1 
HETATM 4645 O O   . HOH EB 5 .   ? 12.62294  -17.08068 20.29466  1.000 29.76225 ? 786  HOH A O   1 
HETATM 4646 O O   . HOH EB 5 .   ? -2.75748  -12.97293 13.07462  0.697 16.65427 ? 787  HOH A O   1 
HETATM 4647 O O   . HOH EB 5 .   ? -18.89603 -38.78143 38.14489  1.000 41.53954 ? 788  HOH A O   1 
HETATM 4648 O O   . HOH EB 5 .   ? -10.88865 2.01308   35.96791  1.000 19.68925 ? 789  HOH A O   1 
HETATM 4649 O O   . HOH EB 5 .   ? -16.43321 -8.34452  42.00349  1.000 20.53426 ? 790  HOH A O   1 
HETATM 4650 O O   . HOH EB 5 .   ? -24.35154 -2.25746  -3.74297  1.000 40.79753 ? 791  HOH A O   1 
HETATM 4651 O O   . HOH EB 5 .   ? -20.13891 -43.98304 30.35066  1.000 52.11591 ? 792  HOH A O   1 
HETATM 4652 O O   . HOH EB 5 .   ? 15.73727  -1.59884  25.29603  1.000 38.76362 ? 793  HOH A O   1 
HETATM 4653 O O   . HOH EB 5 .   ? -18.75601 3.73190   34.60732  1.000 47.60872 ? 794  HOH A O   1 
HETATM 4654 O O   . HOH EB 5 .   ? 22.37568  -14.28004 36.78446  1.000 33.16663 ? 795  HOH A O   1 
HETATM 4655 O O   . HOH EB 5 .   ? -0.51969  -3.25373  41.81519  1.000 19.25128 ? 796  HOH A O   1 
HETATM 4656 O O   . HOH EB 5 .   ? 19.06125  1.90104   33.43628  1.000 53.58707 ? 797  HOH A O   1 
HETATM 4657 O O   . HOH EB 5 .   ? -33.06674 -21.02531 41.96272  1.000 28.76902 ? 798  HOH A O   1 
HETATM 4658 O O   . HOH EB 5 .   ? 17.42558  -1.63454  36.19808  1.000 22.50426 ? 799  HOH A O   1 
HETATM 4659 O O   . HOH EB 5 .   ? 0.09660   -30.21479 36.41361  1.000 39.54970 ? 800  HOH A O   1 
HETATM 4660 O O   . HOH EB 5 .   ? -3.48961  -4.60730  50.75656  1.000 35.24140 ? 801  HOH A O   1 
HETATM 4661 O O   . HOH EB 5 .   ? 10.03345  -14.97760 28.16848  1.000 20.62517 ? 802  HOH A O   1 
HETATM 4662 O O   . HOH EB 5 .   ? -18.36737 5.13190   41.17727  1.000 46.24789 ? 803  HOH A O   1 
HETATM 4663 O O   . HOH EB 5 .   ? -10.51471 -24.66750 52.98172  1.000 28.37935 ? 804  HOH A O   1 
HETATM 4664 O O   . HOH EB 5 .   ? -0.25433  -4.17579  46.13147  1.000 27.87802 ? 805  HOH A O   1 
HETATM 4665 O O   . HOH EB 5 .   ? -21.20783 -13.91477 12.41388  1.000 21.53573 ? 806  HOH A O   1 
HETATM 4666 O O   . HOH EB 5 .   ? 9.79598   -19.59357 17.90647  1.000 41.85967 ? 807  HOH A O   1 
HETATM 4667 O O   . HOH EB 5 .   ? -0.70185  -35.63485 21.20425  1.000 37.23049 ? 808  HOH A O   1 
HETATM 4668 O O   . HOH EB 5 .   ? 0.46031   -8.00250  6.11853   1.000 26.39692 ? 809  HOH A O   1 
HETATM 4669 O O   . HOH EB 5 .   ? 0.58400   -30.63859 56.23651  1.000 33.04667 ? 810  HOH A O   1 
HETATM 4670 O O   . HOH EB 5 .   ? -9.31156  -33.13001 12.77551  0.838 24.45198 ? 811  HOH A O   1 
HETATM 4671 O O   . HOH EB 5 .   ? -9.26037  -38.45547 15.12800  1.000 44.46436 ? 812  HOH A O   1 
HETATM 4672 O O   . HOH EB 5 .   ? -14.07627 -23.45352 52.40594  1.000 25.84135 ? 813  HOH A O   1 
HETATM 4673 O O   . HOH EB 5 .   ? -10.36780 -40.43780 35.88899  1.000 36.08655 ? 814  HOH A O   1 
HETATM 4674 O O   . HOH EB 5 .   ? 11.39150  0.01376   18.43742  1.000 40.05778 ? 815  HOH A O   1 
HETATM 4675 O O   . HOH EB 5 .   ? 22.06076  -19.76668 38.20228  1.000 37.87723 ? 816  HOH A O   1 
HETATM 4676 O O   . HOH EB 5 .   ? 20.69402  -4.01078  29.76771  1.000 47.57175 ? 817  HOH A O   1 
HETATM 4677 O O   . HOH EB 5 .   ? 4.85473   -25.33467 42.93812  1.000 49.41899 ? 818  HOH A O   1 
HETATM 4678 O O   . HOH EB 5 .   ? 11.20278  3.83782   37.46757  1.000 45.03832 ? 819  HOH A O   1 
HETATM 4679 O O   . HOH EB 5 .   ? -4.46734  10.88984  25.48459  1.000 35.27477 ? 820  HOH A O   1 
HETATM 4680 O O   . HOH EB 5 .   ? 12.59300  -3.84230  17.82240  1.000 31.80700 ? 821  HOH A O   1 
HETATM 4681 O O   . HOH EB 5 .   ? 4.29584   -14.01187 13.19069  1.000 28.47133 ? 822  HOH A O   1 
HETATM 4682 O O   . HOH EB 5 .   ? -4.29135  -3.41827  17.36482  1.000 18.30992 ? 823  HOH A O   1 
HETATM 4683 O O   . HOH EB 5 .   ? -30.28688 -2.08583  0.60012   1.000 38.19847 ? 824  HOH A O   1 
HETATM 4684 O O   . HOH EB 5 .   ? 1.33280   -32.00664 26.88960  1.000 35.94589 ? 825  HOH A O   1 
HETATM 4685 O O   . HOH EB 5 .   ? 25.18128  -9.68144  37.60496  1.000 32.61833 ? 826  HOH A O   1 
HETATM 4686 O O   . HOH EB 5 .   ? -4.63734  -10.60282 53.96451  1.000 43.62578 ? 827  HOH A O   1 
HETATM 4687 O O   . HOH EB 5 .   ? -1.87213  -39.67465 35.12171  1.000 33.93931 ? 828  HOH A O   1 
HETATM 4688 O O   . HOH EB 5 .   ? -3.63567  -23.49892 43.80375  1.000 23.98053 ? 829  HOH A O   1 
HETATM 4689 O O   . HOH EB 5 .   ? -28.66978 -23.61800 32.58314  1.000 19.48763 ? 830  HOH A O   1 
HETATM 4690 O O   . HOH EB 5 .   ? -15.54907 -5.21482  6.84638   1.000 21.15131 ? 831  HOH A O   1 
HETATM 4691 O O   . HOH EB 5 .   ? 5.09908   -6.72869  10.58135  1.000 35.84258 ? 832  HOH A O   1 
HETATM 4692 O O   . HOH EB 5 .   ? 20.26166  -23.80578 40.25808  1.000 31.79860 ? 833  HOH A O   1 
HETATM 4693 O O   . HOH EB 5 .   ? 3.22237   -31.23850 55.21212  1.000 46.61907 ? 834  HOH A O   1 
HETATM 4694 O O   . HOH EB 5 .   ? -4.64203  4.08006   43.02472  1.000 49.65676 ? 835  HOH A O   1 
HETATM 4695 O O   . HOH EB 5 .   ? 17.773    -14.556   17.032    1.000 30.75567 ? 836  HOH A O   1 
HETATM 4696 O O   . HOH EB 5 .   ? -23.24221 -14.62818 35.10112  1.000 24.23380 ? 837  HOH A O   1 
HETATM 4697 O O   . HOH EB 5 .   ? -30.87693 12.04154  -9.52921  0.804 34.98183 ? 838  HOH A O   1 
HETATM 4698 O O   . HOH EB 5 .   ? 21.73372  -4.61764  39.56810  1.000 27.09175 ? 839  HOH A O   1 
HETATM 4699 O O   . HOH EB 5 .   ? 15.84598  -14.08159 47.47612  1.000 53.00992 ? 840  HOH A O   1 
HETATM 4700 O O   . HOH EB 5 .   ? -5.05223  -1.98677  19.78084  1.000 19.04160 ? 841  HOH A O   1 
HETATM 4701 O O   . HOH EB 5 .   ? -19.74630 -4.96393  -0.08336  1.000 23.66265 ? 842  HOH A O   1 
HETATM 4702 O O   . HOH EB 5 .   ? -12.31860 1.71341   -2.67937  1.000 27.45586 ? 843  HOH A O   1 
HETATM 4703 O O   . HOH EB 5 .   ? -3.90298  -28.77345 30.80059  1.000 19.75304 ? 844  HOH A O   1 
HETATM 4704 O O   . HOH EB 5 .   ? 2.85927   -2.62703  17.74391  1.000 21.42009 ? 845  HOH A O   1 
HETATM 4705 O O   . HOH EB 5 .   ? 20.36441  -8.48516  47.09062  1.000 39.48785 ? 846  HOH A O   1 
HETATM 4706 O O   . HOH EB 5 .   ? -4.65456  2.66589   15.08629  1.000 34.79119 ? 847  HOH A O   1 
HETATM 4707 O O   . HOH EB 5 .   ? 3.76804   -5.23870  30.12114  1.000 18.12590 ? 848  HOH A O   1 
HETATM 4708 O O   . HOH EB 5 .   ? 1.21592   -8.87857  31.49514  1.000 23.47653 ? 849  HOH A O   1 
HETATM 4709 O O   . HOH EB 5 .   ? 4.60633   6.70931   19.03674  1.000 54.15181 ? 850  HOH A O   1 
HETATM 4710 O O   . HOH EB 5 .   ? -13.76462 10.55811  -5.50840  1.000 48.38715 ? 851  HOH A O   1 
HETATM 4711 O O   . HOH EB 5 .   ? -23.76281 -10.32217 42.58697  1.000 48.28242 ? 852  HOH A O   1 
HETATM 4712 O O   . HOH EB 5 .   ? -21.15247 -40.29086 29.21782  1.000 24.12537 ? 853  HOH A O   1 
HETATM 4713 O O   . HOH EB 5 .   ? -6.39078  0.59911   43.11511  1.000 30.76265 ? 854  HOH A O   1 
HETATM 4714 O O   . HOH EB 5 .   ? 1.20509   -9.22892  52.65369  1.000 27.24626 ? 855  HOH A O   1 
HETATM 4715 O O   . HOH EB 5 .   ? 0.65101   -18.69884 48.67951  0.603 22.61976 ? 856  HOH A O   1 
HETATM 4716 O O   . HOH EB 5 .   ? 10.61585  -12.07861 50.08350  1.000 23.37480 ? 857  HOH A O   1 
HETATM 4717 O O   . HOH EB 5 .   ? 2.75008   -34.58940 24.45462  1.000 53.74400 ? 858  HOH A O   1 
HETATM 4718 O O   . HOH EB 5 .   ? -15.01744 1.66040   48.65544  1.000 53.37722 ? 859  HOH A O   1 
HETATM 4719 O O   . HOH EB 5 .   ? -20.03667 -14.83806 3.35896   1.000 38.16268 ? 860  HOH A O   1 
HETATM 4720 O O   . HOH EB 5 .   ? 12.08199  2.47991   28.63796  1.000 40.23182 ? 861  HOH A O   1 
HETATM 4721 O O   . HOH EB 5 .   ? -21.55847 -25.55139 12.30473  1.000 28.91305 ? 862  HOH A O   1 
HETATM 4722 O O   . HOH EB 5 .   ? -13.64213 -36.87795 50.47234  1.000 32.82815 ? 863  HOH A O   1 
HETATM 4723 O O   . HOH EB 5 .   ? -10.52014 -0.17426  19.10108  1.000 27.69587 ? 864  HOH A O   1 
HETATM 4724 O O   . HOH EB 5 .   ? 11.65777  -11.49149 45.71100  1.000 30.91099 ? 865  HOH A O   1 
HETATM 4725 O O   . HOH EB 5 .   ? -12.07183 -1.43413  2.50224   1.000 22.36044 ? 866  HOH A O   1 
HETATM 4726 O O   . HOH EB 5 .   ? -12.00778 1.95712   20.35528  1.000 53.41889 ? 867  HOH A O   1 
HETATM 4727 O O   . HOH EB 5 .   ? -14.30572 4.15250   -1.29324  1.000 35.01225 ? 868  HOH A O   1 
HETATM 4728 O O   . HOH EB 5 .   ? 19.88359  -13.33623 43.86360  1.000 56.80553 ? 869  HOH A O   1 
HETATM 4729 O O   . HOH EB 5 .   ? -17.52972 -39.43430 23.53115  1.000 21.08947 ? 870  HOH A O   1 
HETATM 4730 O O   . HOH EB 5 .   ? -9.92516  -24.34988 56.39692  1.000 43.98004 ? 871  HOH A O   1 
HETATM 4731 O O   . HOH EB 5 .   ? -3.63084  -39.22888 48.17574  1.000 35.58980 ? 872  HOH A O   1 
HETATM 4732 O O   . HOH EB 5 .   ? 26.08924  -7.93133  33.53660  1.000 21.60018 ? 873  HOH A O   1 
HETATM 4733 O O   . HOH EB 5 .   ? -15.85334 -10.25282 54.05728  1.000 43.25357 ? 874  HOH A O   1 
HETATM 4734 O O   . HOH EB 5 .   ? -1.38745  -24.40673 45.21627  1.000 21.60698 ? 875  HOH A O   1 
HETATM 4735 O O   . HOH EB 5 .   ? 2.13866   -6.41373  18.25882  1.000 18.93856 ? 876  HOH A O   1 
HETATM 4736 O O   . HOH EB 5 .   ? 7.25599   3.27852   37.54932  1.000 42.63682 ? 877  HOH A O   1 
HETATM 4737 O O   . HOH EB 5 .   ? -18.12449 -7.72391  39.93276  1.000 19.64040 ? 878  HOH A O   1 
HETATM 4738 O O   . HOH EB 5 .   ? -23.97581 -32.61342 19.43546  1.000 35.97424 ? 879  HOH A O   1 
HETATM 4739 O O   . HOH EB 5 .   ? -16.47246 1.62285   40.63760  1.000 27.93566 ? 880  HOH A O   1 
HETATM 4740 O O   . HOH EB 5 .   ? -19.38951 -2.67185  22.49906  1.000 30.94839 ? 881  HOH A O   1 
HETATM 4741 O O   . HOH EB 5 .   ? 20.90395  -11.88388 30.75840  1.000 16.89811 ? 882  HOH A O   1 
HETATM 4742 O O   . HOH EB 5 .   ? -23.64989 -41.71814 22.79692  1.000 26.70283 ? 883  HOH A O   1 
HETATM 4743 O O   . HOH EB 5 .   ? 13.62825  -27.48916 34.43986  1.000 36.97145 ? 884  HOH A O   1 
HETATM 4744 O O   . HOH EB 5 .   ? -16.17188 -43.77701 23.66270  1.000 31.42052 ? 885  HOH A O   1 
HETATM 4745 O O   . HOH EB 5 .   ? -8.70989  -19.52786 9.12807   1.000 20.75954 ? 886  HOH A O   1 
HETATM 4746 O O   . HOH EB 5 .   ? -26.34189 -39.47873 20.19303  1.000 20.73150 ? 887  HOH A O   1 
HETATM 4747 O O   . HOH EB 5 .   ? -12.07512 -19.42921 53.11677  1.000 26.01536 ? 888  HOH A O   1 
HETATM 4748 O O   . HOH EB 5 .   ? -6.13062  -3.33118  45.57026  1.000 22.24536 ? 889  HOH A O   1 
HETATM 4749 O O   . HOH EB 5 .   ? 25.39503  -5.04494  41.36589  1.000 38.31248 ? 890  HOH A O   1 
HETATM 4750 O O   . HOH EB 5 .   ? -0.75156  -25.45512 52.38808  1.000 21.15717 ? 891  HOH A O   1 
HETATM 4751 O O   . HOH EB 5 .   ? -23.43726 -11.28990 30.00158  1.000 35.46565 ? 892  HOH A O   1 
HETATM 4752 O O   . HOH EB 5 .   ? -3.01692  4.46325   25.06323  1.000 21.31958 ? 893  HOH A O   1 
HETATM 4753 O O   . HOH EB 5 .   ? -22.03024 -37.12726 44.45351  1.000 44.67296 ? 894  HOH A O   1 
HETATM 4754 O O   . HOH EB 5 .   ? -6.18240  -34.02575 39.15281  1.000 29.81607 ? 895  HOH A O   1 
HETATM 4755 O O   . HOH EB 5 .   ? 4.49151   -9.86534  20.91292  1.000 25.91400 ? 896  HOH A O   1 
HETATM 4756 O O   . HOH EB 5 .   ? -22.00825 -2.88748  41.24416  1.000 45.43349 ? 897  HOH A O   1 
HETATM 4757 O O   . HOH EB 5 .   ? -20.39434 12.37454  -7.66498  1.000 36.86182 ? 898  HOH A O   1 
HETATM 4758 O O   . HOH EB 5 .   ? -22.12298 -24.13309 49.54406  1.000 42.62253 ? 899  HOH A O   1 
HETATM 4759 O O   . HOH EB 5 .   ? 7.28368   -30.20500 54.27760  1.000 51.56416 ? 900  HOH A O   1 
HETATM 4760 O O   . HOH EB 5 .   ? -20.95862 -4.02950  2.34079   1.000 31.26578 ? 901  HOH A O   1 
HETATM 4761 O O   . HOH EB 5 .   ? -33.11264 6.81988   -0.74373  1.000 37.46834 ? 902  HOH A O   1 
HETATM 4762 O O   . HOH EB 5 .   ? -14.15861 -30.47929 52.80032  1.000 48.17428 ? 903  HOH A O   1 
HETATM 4763 O O   . HOH EB 5 .   ? -29.65459 -19.42976 29.26545  1.000 43.36897 ? 904  HOH A O   1 
HETATM 4764 O O   . HOH EB 5 .   ? -10.21636 -18.57337 54.88515  1.000 27.40206 ? 905  HOH A O   1 
HETATM 4765 O O   . HOH EB 5 .   ? 0.66054   -18.66942 45.94829  1.000 26.01130 ? 906  HOH A O   1 
HETATM 4766 O O   . HOH EB 5 .   ? -15.10906 -40.38254 18.02160  1.000 25.58314 ? 907  HOH A O   1 
HETATM 4767 O O   . HOH EB 5 .   ? -28.21326 2.32874   -12.22940 1.000 45.15443 ? 908  HOH A O   1 
HETATM 4768 O O   . HOH EB 5 .   ? -0.64294  -20.31566 51.99572  1.000 46.51305 ? 909  HOH A O   1 
HETATM 4769 O O   . HOH EB 5 .   ? -23.28504 -18.99547 45.34760  1.000 22.38161 ? 910  HOH A O   1 
HETATM 4770 O O   . HOH EB 5 .   ? -27.31760 -18.62518 45.32999  0.708 33.40938 ? 911  HOH A O   1 
HETATM 4771 O O   . HOH EB 5 .   ? -5.04600  -8.59710  29.48789  1.000 15.96192 ? 912  HOH A O   1 
HETATM 4772 O O   . HOH EB 5 .   ? -9.95694  -42.95454 22.18209  1.000 27.86705 ? 913  HOH A O   1 
HETATM 4773 O O   . HOH EB 5 .   ? -11.34330 10.13565  37.26587  1.000 31.47340 ? 914  HOH A O   1 
HETATM 4774 O O   . HOH EB 5 .   ? -20.45484 -10.51097 46.14695  1.000 30.35230 ? 915  HOH A O   1 
HETATM 4775 O O   . HOH EB 5 .   ? 0.45882   9.96647   19.47880  1.000 62.32466 ? 916  HOH A O   1 
HETATM 4776 O O   . HOH EB 5 .   ? 18.81898  -15.35348 39.85186  1.000 29.63402 ? 917  HOH A O   1 
HETATM 4777 O O   . HOH EB 5 .   ? 3.38465   -18.94234 46.01097  1.000 24.68842 ? 918  HOH A O   1 
HETATM 4778 O O   . HOH EB 5 .   ? -3.24256  -3.24256  0.00000   0.50  52.65588 ? 919  HOH A O   1 
HETATM 4779 O O   . HOH EB 5 .   ? -23.34753 -3.80108  13.38466  1.000 31.03956 ? 920  HOH A O   1 
HETATM 4780 O O   . HOH EB 5 .   ? -27.92906 8.06235   12.24168  1.000 44.53190 ? 921  HOH A O   1 
HETATM 4781 O O   . HOH EB 5 .   ? -10.04945 0.64792   -0.12350  1.000 31.19101 ? 922  HOH A O   1 
HETATM 4782 O O   . HOH EB 5 .   ? 7.88909   -16.23801 29.58700  1.000 19.07205 ? 923  HOH A O   1 
HETATM 4783 O O   . HOH EB 5 .   ? 20.36074  -12.73390 35.64313  1.000 18.52105 ? 924  HOH A O   1 
HETATM 4784 O O   . HOH EB 5 .   ? -31.39506 3.22728   -8.62916  1.000 40.57589 ? 925  HOH A O   1 
HETATM 4785 O O   . HOH EB 5 .   ? -19.85964 -4.54756  38.18908  1.000 23.78602 ? 926  HOH A O   1 
HETATM 4786 O O   . HOH EB 5 .   ? 19.49841  -20.66440 30.07998  1.000 20.97208 ? 927  HOH A O   1 
HETATM 4787 O O   . HOH EB 5 .   ? -6.98674  -29.23362 17.52181  1.000 20.04636 ? 928  HOH A O   1 
HETATM 4788 O O   . HOH EB 5 .   ? -4.82334  -17.13660 22.79668  1.000 18.19254 ? 929  HOH A O   1 
HETATM 4789 O O   . HOH EB 5 .   ? -5.49239  -10.50003 17.66617  1.000 16.35208 ? 930  HOH A O   1 
HETATM 4790 O O   . HOH EB 5 .   ? -11.06747 -22.51762 22.89074  1.000 17.60693 ? 931  HOH A O   1 
HETATM 4791 O O   . HOH EB 5 .   ? -14.78766 -39.55174 38.60908  1.000 43.10209 ? 932  HOH A O   1 
HETATM 4792 O O   . HOH EB 5 .   ? 8.22402   2.67972   23.19261  1.000 28.39618 ? 933  HOH A O   1 
HETATM 4793 O O   . HOH EB 5 .   ? -15.26330 6.04607   32.72586  1.000 37.90317 ? 934  HOH A O   1 
HETATM 4794 O O   . HOH EB 5 .   ? 11.25402  -2.21123  49.59618  1.000 19.57257 ? 935  HOH A O   1 
HETATM 4795 O O   . HOH EB 5 .   ? -21.68012 -8.97515  33.12495  1.000 30.16544 ? 936  HOH A O   1 
HETATM 4796 O O   . HOH EB 5 .   ? 0.52487   -9.57738  36.37947  1.000 18.84506 ? 937  HOH A O   1 
HETATM 4797 O O   . HOH EB 5 .   ? -2.43873  -25.95364 20.15172  1.000 21.73131 ? 938  HOH A O   1 
HETATM 4798 O O   . HOH EB 5 .   ? -31.03271 5.46632   14.39298  1.000 46.42482 ? 939  HOH A O   1 
HETATM 4799 O O   . HOH EB 5 .   ? -12.48330 -24.51117 24.37409  1.000 16.52841 ? 940  HOH A O   1 
HETATM 4800 O O   . HOH EB 5 .   ? 4.29005   -21.13432 38.64180  1.000 27.76126 ? 941  HOH A O   1 
HETATM 4801 O O   . HOH EB 5 .   ? 15.58021  -27.10118 35.76387  1.000 34.50771 ? 942  HOH A O   1 
HETATM 4802 O O   . HOH EB 5 .   ? -12.53999 -4.14507  46.23483  1.000 24.56824 ? 943  HOH A O   1 
HETATM 4803 O O   . HOH EB 5 .   ? -21.03681 -7.72201  17.70340  1.000 25.62975 ? 944  HOH A O   1 
HETATM 4804 O O   . HOH EB 5 .   ? -17.11696 0.61707   15.08663  1.000 45.43677 ? 945  HOH A O   1 
HETATM 4805 O O   . HOH EB 5 .   ? -15.77137 3.36347   10.22369  1.000 51.44133 ? 946  HOH A O   1 
HETATM 4806 O O   . HOH EB 5 .   ? 0.44033   6.10958   19.05418  1.000 33.82778 ? 947  HOH A O   1 
HETATM 4807 O O   . HOH EB 5 .   ? -0.34593  -5.88970  50.04334  1.000 32.12603 ? 948  HOH A O   1 
HETATM 4808 O O   . HOH EB 5 .   ? -24.13495 -13.86120 29.38496  1.000 26.46551 ? 949  HOH A O   1 
HETATM 4809 O O   . HOH EB 5 .   ? 2.03666   4.13780   39.73341  1.000 40.60095 ? 950  HOH A O   1 
HETATM 4810 O O   . HOH EB 5 .   ? 14.68061  -4.73439  42.62429  1.000 20.46447 ? 951  HOH A O   1 
HETATM 4811 O O   . HOH EB 5 .   ? -8.13110  -32.96263 50.15911  0.489 21.95797 ? 952  HOH A O   1 
HETATM 4812 O O   . HOH EB 5 .   ? -28.15438 6.92038   -8.28230  1.000 32.51270 ? 953  HOH A O   1 
HETATM 4813 O O   . HOH EB 5 .   ? 10.88363  -27.55463 43.93133  1.000 42.06600 ? 954  HOH A O   1 
HETATM 4814 O O   . HOH EB 5 .   ? 3.76311   -9.68862  47.15845  1.000 18.12882 ? 955  HOH A O   1 
HETATM 4815 O O   . HOH EB 5 .   ? -22.41646 -5.98615  6.59680   1.000 37.48267 ? 956  HOH A O   1 
HETATM 4816 O O   . HOH EB 5 .   ? -28.91145 -4.40528  4.20096   1.000 43.65238 ? 957  HOH A O   1 
HETATM 4817 O O   . HOH EB 5 .   ? -8.56767  -27.88077 10.03098  1.000 34.34270 ? 958  HOH A O   1 
HETATM 4818 O O   . HOH EB 5 .   ? -4.20786  -14.09554 47.91819  1.000 22.99306 ? 959  HOH A O   1 
HETATM 4819 O O   . HOH EB 5 .   ? -0.01828  -2.64271  5.27696   1.000 43.39537 ? 960  HOH A O   1 
HETATM 4820 O O   . HOH EB 5 .   ? -20.55204 -1.57978  30.67036  1.000 27.16214 ? 961  HOH A O   1 
HETATM 4821 O O   . HOH EB 5 .   ? 21.70906  -16.20117 32.49329  1.000 25.54840 ? 962  HOH A O   1 
HETATM 4822 O O   . HOH EB 5 .   ? -22.63892 -4.38578  32.88750  1.000 41.06750 ? 963  HOH A O   1 
HETATM 4823 O O   . HOH EB 5 .   ? -35.409   -33.071   39.856    1.000 40.23336 ? 964  HOH A O   1 
HETATM 4824 O O   . HOH EB 5 .   ? -4.65900  -9.92689  20.29131  1.000 17.17039 ? 965  HOH A O   1 
HETATM 4825 O O   . HOH EB 5 .   ? 20.53115  -29.28114 31.36607  1.000 35.68019 ? 966  HOH A O   1 
HETATM 4826 O O   . HOH EB 5 .   ? -19.05595 0.35423   37.08376  1.000 41.35882 ? 967  HOH A O   1 
HETATM 4827 O O   . HOH EB 5 .   ? -22.95274 -3.58616  23.17706  1.000 40.84647 ? 968  HOH A O   1 
HETATM 4828 O O   . HOH EB 5 .   ? -5.42689  -28.31993 19.89746  1.000 19.70181 ? 969  HOH A O   1 
HETATM 4829 O O   . HOH EB 5 .   ? -19.55887 -30.43791 9.17043   1.000 51.50682 ? 970  HOH A O   1 
HETATM 4830 O O   . HOH EB 5 .   ? -11.06730 -37.90603 41.05450  1.000 26.94628 ? 971  HOH A O   1 
HETATM 4831 O O   . HOH EB 5 .   ? -4.29567  -22.16605 56.23543  1.000 52.79130 ? 972  HOH A O   1 
HETATM 4832 O O   . HOH EB 5 .   ? -14.45315 -40.91496 46.76929  1.000 45.81163 ? 973  HOH A O   1 
HETATM 4833 O O   . HOH EB 5 .   ? 7.14372   -10.06862 19.74980  1.000 25.30357 ? 974  HOH A O   1 
HETATM 4834 O O   . HOH EB 5 .   ? 1.047     -17.978   57.076    1.000 46.63109 ? 975  HOH A O   1 
HETATM 4835 O O   . HOH EB 5 .   ? 16.539    -13.715   12.575    1.000 45.68486 ? 976  HOH A O   1 
HETATM 4836 O O   . HOH EB 5 .   ? -2.04280  -32.21666 16.30601  1.000 36.01463 ? 977  HOH A O   1 
HETATM 4837 O O   . HOH EB 5 .   ? -21.98750 -27.58787 14.10207  1.000 20.91400 ? 978  HOH A O   1 
HETATM 4838 O O   . HOH EB 5 .   ? 0.47725   -33.43096 52.68519  1.000 36.99446 ? 979  HOH A O   1 
HETATM 4839 O O   . HOH EB 5 .   ? -3.67883  -15.02166 51.39274  1.000 34.47619 ? 980  HOH A O   1 
HETATM 4840 O O   . HOH EB 5 .   ? -8.71825  -40.59203 21.37515  1.000 20.89161 ? 981  HOH A O   1 
HETATM 4841 O O   . HOH EB 5 .   ? -24.73168 -22.27916 18.32782  1.000 18.80659 ? 982  HOH A O   1 
HETATM 4842 O O   . HOH EB 5 .   ? -33.20679 -1.26388  -3.77812  1.000 43.56926 ? 983  HOH A O   1 
HETATM 4843 O O   . HOH EB 5 .   ? -29.94363 5.18513   -10.81736 1.000 42.60824 ? 984  HOH A O   1 
HETATM 4844 O O   . HOH EB 5 .   ? -13.01313 -39.08021 36.49975  1.000 24.34572 ? 985  HOH A O   1 
HETATM 4845 O O   . HOH EB 5 .   ? -4.02565  -1.68905  30.62799  1.000 18.14114 ? 986  HOH A O   1 
HETATM 4846 O O   . HOH EB 5 .   ? -25.56035 -20.34735 46.05160  1.000 33.59864 ? 987  HOH A O   1 
HETATM 4847 O O   . HOH EB 5 .   ? 9.66563   -14.51106 16.17270  1.000 38.09207 ? 988  HOH A O   1 
HETATM 4848 O O   . HOH EB 5 .   ? -1.47361  -1.88338  8.81508   1.000 32.20898 ? 989  HOH A O   1 
HETATM 4849 O O   . HOH EB 5 .   ? -25.69969 -14.50094 34.04549  1.000 35.45063 ? 990  HOH A O   1 
HETATM 4850 O O   . HOH EB 5 .   ? -4.68776  -21.27386 41.82190  1.000 19.00265 ? 991  HOH A O   1 
HETATM 4851 O O   . HOH EB 5 .   ? -24.97113 -24.33620 14.38063  1.000 19.88295 ? 992  HOH A O   1 
HETATM 4852 O O   . HOH EB 5 .   ? -30.50201 13.27029  -0.46161  1.000 43.39473 ? 993  HOH A O   1 
HETATM 4853 O O   . HOH EB 5 .   ? -19.54466 -41.33617 41.24637  1.000 49.02422 ? 994  HOH A O   1 
HETATM 4854 O O   . HOH EB 5 .   ? -3.76831  -35.74101 18.17545  1.000 32.78813 ? 995  HOH A O   1 
HETATM 4855 O O   . HOH EB 5 .   ? -24.16442 -26.86179 42.47261  1.000 24.15652 ? 996  HOH A O   1 
HETATM 4856 O O   . HOH EB 5 .   ? -21.71253 -8.20336  1.97443   1.000 42.90255 ? 997  HOH A O   1 
HETATM 4857 O O   . HOH EB 5 .   ? -1.21514  -34.75330 19.15381  1.000 51.11862 ? 998  HOH A O   1 
HETATM 4858 O O   . HOH EB 5 .   ? -34.22854 4.20388   2.34726   1.000 41.23321 ? 999  HOH A O   1 
HETATM 4859 O O   . HOH EB 5 .   ? -21.16706 4.29083   16.70391  1.000 46.05381 ? 1000 HOH A O   1 
HETATM 4860 O O   . HOH EB 5 .   ? 20.19145  -3.61163  37.47695  1.000 20.26748 ? 1001 HOH A O   1 
HETATM 4861 O O   . HOH EB 5 .   ? -12.47660 -19.75154 30.75233  1.000 17.22929 ? 1002 HOH A O   1 
HETATM 4862 O O   . HOH EB 5 .   ? -18.91869 -29.72366 46.28475  1.000 21.64241 ? 1003 HOH A O   1 
HETATM 4863 O O   . HOH EB 5 .   ? 4.04433   -2.99850  22.25747  1.000 28.03163 ? 1004 HOH A O   1 
HETATM 4864 O O   . HOH EB 5 .   ? -14.57550 -19.42898 54.30266  1.000 31.54510 ? 1005 HOH A O   1 
HETATM 4865 O O   . HOH EB 5 .   ? -12.11323 -19.45782 10.72820  1.000 18.75031 ? 1006 HOH A O   1 
HETATM 4866 O O   . HOH EB 5 .   ? -1.06719  -16.40965 23.00495  1.000 22.68993 ? 1007 HOH A O   1 
HETATM 4867 O O   . HOH EB 5 .   ? -3.35403  -23.81017 30.14152  1.000 22.43428 ? 1008 HOH A O   1 
HETATM 4868 O O   . HOH EB 5 .   ? -14.04682 -21.60575 11.41249  1.000 21.71848 ? 1009 HOH A O   1 
HETATM 4869 O O   . HOH EB 5 .   ? -24.40692 -27.98921 15.08269  1.000 20.98941 ? 1010 HOH A O   1 
HETATM 4870 O O   . HOH EB 5 .   ? 0.891     -19.251   12.639    1.000 45.75934 ? 1011 HOH A O   1 
HETATM 4871 O O   . HOH EB 5 .   ? -24.36166 -31.30140 42.68244  1.000 29.48152 ? 1012 HOH A O   1 
HETATM 4872 O O   . HOH EB 5 .   ? -5.50626  -40.77881 23.60380  1.000 39.92849 ? 1013 HOH A O   1 
HETATM 4873 O O   . HOH EB 5 .   ? -34.63447 10.30034  -8.61307  1.000 51.40732 ? 1014 HOH A O   1 
HETATM 4874 O O   . HOH EB 5 .   ? -24.59293 -22.15817 38.53817  1.000 19.40314 ? 1015 HOH A O   1 
HETATM 4875 O O   . HOH EB 5 .   ? -5.36694  4.58457   17.17362  1.000 29.94789 ? 1016 HOH A O   1 
HETATM 4876 O O   . HOH EB 5 .   ? -26.51404 -5.32899  8.35620   1.000 43.24338 ? 1017 HOH A O   1 
HETATM 4877 O O   . HOH EB 5 .   ? 1.65996   -29.12040 58.32726  1.000 42.42299 ? 1018 HOH A O   1 
HETATM 4878 O O   . HOH EB 5 .   ? 1.27859   -19.29396 35.12099  1.000 26.57258 ? 1019 HOH A O   1 
HETATM 4879 O O   . HOH EB 5 .   ? -13.22967 -33.68327 15.42738  1.000 23.09815 ? 1020 HOH A O   1 
HETATM 4880 O O   . HOH EB 5 .   ? -27.23783 11.64197  -2.03672  1.000 31.60208 ? 1021 HOH A O   1 
HETATM 4881 O O   . HOH EB 5 .   ? 27.55917  -7.51859  36.08553  1.000 43.40591 ? 1022 HOH A O   1 
HETATM 4882 O O   . HOH EB 5 .   ? 2.51027   4.49160   19.37845  1.000 30.33191 ? 1023 HOH A O   1 
HETATM 4883 O O   . HOH EB 5 .   ? 0.37810   -8.23828  2.14408   1.000 41.64009 ? 1024 HOH A O   1 
HETATM 4884 O O   . HOH EB 5 .   ? -19.91379 -14.91352 -0.17188  1.000 44.96910 ? 1025 HOH A O   1 
HETATM 4885 O O   . HOH EB 5 .   ? -5.71625  -14.89327 45.73881  1.000 16.55717 ? 1026 HOH A O   1 
HETATM 4886 O O   . HOH EB 5 .   ? -21.87197 -11.21584 49.44555  1.000 59.60231 ? 1027 HOH A O   1 
HETATM 4887 O O   . HOH EB 5 .   ? -23.94559 -29.33563 41.10440  1.000 25.84364 ? 1028 HOH A O   1 
HETATM 4888 O O   . HOH EB 5 .   ? -7.09030  -18.88953 2.99645   1.000 25.44802 ? 1029 HOH A O   1 
HETATM 4889 O O   . HOH EB 5 .   ? -1.87659  -41.79850 42.23687  1.000 50.97827 ? 1030 HOH A O   1 
HETATM 4890 O O   . HOH EB 5 .   ? -2.18487  -16.40613 49.73215  1.000 32.37608 ? 1031 HOH A O   1 
HETATM 4891 O O   . HOH EB 5 .   ? -7.42430  13.33016  32.19781  1.000 55.18564 ? 1032 HOH A O   1 
HETATM 4892 O O   . HOH EB 5 .   ? 10.75850  -26.53579 34.35727  1.000 52.59497 ? 1033 HOH A O   1 
HETATM 4893 O O   . HOH EB 5 .   ? 6.13667   -15.47142 47.15342  1.000 27.63110 ? 1034 HOH A O   1 
HETATM 4894 O O   . HOH EB 5 .   ? -24.71798 -15.23501 21.63640  1.000 18.03285 ? 1035 HOH A O   1 
HETATM 4895 O O   . HOH EB 5 .   ? -11.87607 -25.69684 55.29931  1.000 49.74829 ? 1036 HOH A O   1 
HETATM 4896 O O   . HOH EB 5 .   ? -5.90060  -12.72733 52.65084  1.000 34.94109 ? 1037 HOH A O   1 
HETATM 4897 O O   . HOH EB 5 .   ? -7.66907  -33.77336 36.83892  1.000 21.92748 ? 1038 HOH A O   1 
HETATM 4898 O O   . HOH EB 5 .   ? -15.69964 -19.41144 33.35204  1.000 15.91555 ? 1039 HOH A O   1 
HETATM 4899 O O   . HOH EB 5 .   ? 0.31559   -7.50920  23.84734  1.000 17.45503 ? 1040 HOH A O   1 
HETATM 4900 O O   . HOH EB 5 .   ? -2.59485  -16.06657 18.24361  1.000 17.70277 ? 1041 HOH A O   1 
HETATM 4901 O O   . HOH EB 5 .   ? -25.31475 -36.50419 32.65433  1.000 32.75695 ? 1042 HOH A O   1 
HETATM 4902 O O   . HOH EB 5 .   ? -34.51609 -24.13741 44.26992  1.000 37.85121 ? 1043 HOH A O   1 
HETATM 4903 O O   . HOH EB 5 .   ? -2.45622  -18.70480 26.38060  1.000 26.20714 ? 1044 HOH A O   1 
HETATM 4904 O O   . HOH EB 5 .   ? -30.05848 -0.26285  -8.80173  1.000 39.12050 ? 1045 HOH A O   1 
HETATM 4905 O O   . HOH EB 5 .   ? 22.881    -17.548   30.025    1.000 25.53298 ? 1046 HOH A O   1 
HETATM 4906 O O   . HOH EB 5 .   ? 3.91711   -26.99878 25.08974  1.000 46.03906 ? 1047 HOH A O   1 
HETATM 4907 O O   . HOH EB 5 .   ? -19.22762 0.87349   47.21284  1.000 37.34621 ? 1048 HOH A O   1 
HETATM 4908 O O   . HOH EB 5 .   ? -3.04571  -29.65049 58.07165  1.000 43.71022 ? 1049 HOH A O   1 
HETATM 4909 O O   . HOH EB 5 .   ? 7.15928   -24.47179 36.21472  1.000 40.62009 ? 1050 HOH A O   1 
HETATM 4910 O O   . HOH EB 5 .   ? -2.65373  -15.37534 57.73955  1.000 56.88163 ? 1051 HOH A O   1 
HETATM 4911 O O   . HOH EB 5 .   ? -11.64109 -20.26476 8.26990   1.000 21.46597 ? 1052 HOH A O   1 
HETATM 4912 O O   . HOH EB 5 .   ? 5.66714   -22.34321 48.13042  1.000 29.19347 ? 1053 HOH A O   1 
HETATM 4913 O O   . HOH EB 5 .   ? -2.86197  -7.75872  57.61248  1.000 54.32579 ? 1054 HOH A O   1 
HETATM 4914 O O   . HOH EB 5 .   ? -8.47912  -38.63714 32.52616  1.000 28.70385 ? 1055 HOH A O   1 
HETATM 4915 O O   . HOH EB 5 .   ? 7.30243   -19.34606 39.67136  1.000 24.12104 ? 1056 HOH A O   1 
HETATM 4916 O O   . HOH EB 5 .   ? -25.56796 -15.37802 31.20548  1.000 29.97200 ? 1057 HOH A O   1 
HETATM 4917 O O   . HOH EB 5 .   ? -25.00038 -39.42733 32.28891  1.000 50.76269 ? 1058 HOH A O   1 
HETATM 4918 O O   . HOH EB 5 .   ? 2.04184   -2.77869  20.35457  1.000 20.78548 ? 1059 HOH A O   1 
HETATM 4919 O O   . HOH EB 5 .   ? -19.34943 -27.82573 50.15706  1.000 30.67853 ? 1060 HOH A O   1 
HETATM 4920 O O   . HOH EB 5 .   ? 4.51157   -2.52292  10.68353  1.000 45.19939 ? 1061 HOH A O   1 
HETATM 4921 O O   . HOH EB 5 .   ? -26.83636 -22.66679 20.22020  1.000 29.86742 ? 1062 HOH A O   1 
HETATM 4922 O O   . HOH EB 5 .   ? -31.32746 -4.97412  8.27678   1.000 57.37821 ? 1063 HOH A O   1 
HETATM 4923 O O   . HOH EB 5 .   ? -9.29177  -42.54881 44.19603  1.000 34.43309 ? 1064 HOH A O   1 
HETATM 4924 O O   . HOH EB 5 .   ? -20.67743 -40.41034 43.69427  1.000 57.08321 ? 1065 HOH A O   1 
HETATM 4925 O O   . HOH EB 5 .   ? 25.57492  -4.25589  32.61837  1.000 34.99300 ? 1066 HOH A O   1 
HETATM 4926 O O   . HOH EB 5 .   ? 8.00512   -26.56349 47.33581  1.000 46.94488 ? 1067 HOH A O   1 
HETATM 4927 O O   . HOH EB 5 .   ? -26.15983 -8.16772  38.05620  1.000 46.30857 ? 1068 HOH A O   1 
HETATM 4928 O O   . HOH EB 5 .   ? -26.94628 -20.52149 31.87986  1.000 22.45061 ? 1069 HOH A O   1 
HETATM 4929 O O   . HOH EB 5 .   ? -26.67663 -18.01694 33.26788  1.000 34.59709 ? 1070 HOH A O   1 
HETATM 4930 O O   . HOH EB 5 .   ? -0.16362  -38.94716 24.47124  1.000 54.21487 ? 1071 HOH A O   1 
HETATM 4931 O O   . HOH EB 5 .   ? -16.77814 -32.78124 45.52031  1.000 21.61682 ? 1072 HOH A O   1 
HETATM 4932 O O   . HOH EB 5 .   ? -34.17893 10.18679  -2.30347  1.000 48.78427 ? 1073 HOH A O   1 
HETATM 4933 O O   . HOH EB 5 .   ? -3.81654  6.51901   18.40191  1.000 34.88854 ? 1074 HOH A O   1 
HETATM 4934 O O   . HOH EB 5 .   ? -0.07311  -34.14523 36.84797  1.000 54.93702 ? 1075 HOH A O   1 
HETATM 4935 O O   . HOH EB 5 .   ? -21.42208 -23.34052 9.79330   1.000 33.29894 ? 1076 HOH A O   1 
HETATM 4936 O O   . HOH EB 5 .   ? -28.20992 -35.52592 36.10543  1.000 49.37933 ? 1077 HOH A O   1 
HETATM 4937 O O   . HOH EB 5 .   ? -17.08915 -13.65080 -1.91732  1.000 27.48017 ? 1078 HOH A O   1 
HETATM 4938 O O   . HOH EB 5 .   ? -2.32275  -26.51199 31.02772  1.000 25.04602 ? 1079 HOH A O   1 
HETATM 4939 O O   . HOH EB 5 .   ? -3.47609  -37.48710 22.03391  1.000 41.28307 ? 1080 HOH A O   1 
HETATM 4940 O O   . HOH EB 5 .   ? 22.09402  -26.56441 34.75914  1.000 24.66801 ? 1081 HOH A O   1 
HETATM 4941 O O   . HOH EB 5 .   ? -7.15861  -41.88317 29.07903  1.000 28.03253 ? 1082 HOH A O   1 
HETATM 4942 O O   . HOH EB 5 .   ? -13.94157 11.43887  -8.35368  1.000 45.92443 ? 1083 HOH A O   1 
HETATM 4943 O O   . HOH EB 5 .   ? 9.78745   -3.34783  17.31461  1.000 32.10479 ? 1084 HOH A O   1 
HETATM 4944 O O   . HOH EB 5 .   ? -24.69832 -33.70854 17.62852  1.000 38.11577 ? 1085 HOH A O   1 
HETATM 4945 O O   . HOH EB 5 .   ? 22.65817  -6.97844  27.69924  1.000 29.75732 ? 1086 HOH A O   1 
HETATM 4946 O O   . HOH EB 5 .   ? 6.21587   -3.79406  45.20186  1.000 34.49413 ? 1087 HOH A O   1 
HETATM 4947 O O   . HOH EB 5 .   ? 9.16411   -25.47722 33.01047  1.000 38.70671 ? 1088 HOH A O   1 
HETATM 4948 O O   . HOH EB 5 .   ? -5.29334  9.72699   33.49390  1.000 31.70166 ? 1089 HOH A O   1 
HETATM 4949 O O   . HOH EB 5 .   ? -23.57721 -11.54756 45.96626  1.000 52.17289 ? 1090 HOH A O   1 
HETATM 4950 O O   . HOH EB 5 .   ? -12.85733 0.10870   47.36369  1.000 38.14174 ? 1091 HOH A O   1 
HETATM 4951 O O   . HOH EB 5 .   ? -23.75866 1.86666   -11.15655 1.000 30.00388 ? 1092 HOH A O   1 
HETATM 4952 O O   . HOH EB 5 .   ? -1.10896  -23.65666 41.23248  1.000 29.06228 ? 1093 HOH A O   1 
HETATM 4953 O O   . HOH EB 5 .   ? -6.94245  -6.28594  49.34770  1.000 33.70798 ? 1094 HOH A O   1 
HETATM 4954 O O   . HOH EB 5 .   ? -33.17271 4.51807   5.64623   1.000 47.94684 ? 1095 HOH A O   1 
HETATM 4955 O O   . HOH EB 5 .   ? -9.73226  -40.48937 40.25465  1.000 39.90273 ? 1096 HOH A O   1 
HETATM 4956 O O   . HOH EB 5 .   ? -7.93045  8.28611   24.82894  1.000 32.75536 ? 1097 HOH A O   1 
HETATM 4957 O O   . HOH EB 5 .   ? 2.41501   -16.92454 43.56518  1.000 25.85430 ? 1098 HOH A O   1 
HETATM 4958 O O   . HOH EB 5 .   ? -30.77221 -2.49688  -3.02404  1.000 44.26693 ? 1099 HOH A O   1 
HETATM 4959 O O   . HOH EB 5 .   ? -2.96372  -20.83362 27.91280  1.000 28.60260 ? 1100 HOH A O   1 
HETATM 4960 O O   . HOH EB 5 .   ? -1.63556  -34.81607 34.72677  1.000 45.76905 ? 1101 HOH A O   1 
HETATM 4961 O O   . HOH EB 5 .   ? -3.17918  -16.64746 24.80475  1.000 19.30267 ? 1102 HOH A O   1 
HETATM 4962 O O   . HOH EB 5 .   ? 15.92946  -29.50465 32.63822  1.000 46.08926 ? 1103 HOH A O   1 
HETATM 4963 O O   . HOH EB 5 .   ? 14.49702  -25.10272 19.74102  1.000 47.07135 ? 1104 HOH A O   1 
HETATM 4964 O O   . HOH EB 5 .   ? -4.91833  -29.10107 56.18525  1.000 32.84925 ? 1105 HOH A O   1 
HETATM 4965 O O   . HOH EB 5 .   ? -22.03416 -1.16849  16.56740  1.000 50.56623 ? 1106 HOH A O   1 
HETATM 4966 O O   . HOH EB 5 .   ? -10.15461 -43.82785 29.58774  1.000 33.60744 ? 1107 HOH A O   1 
HETATM 4967 O O   . HOH EB 5 .   ? 12.69152  -0.01697  21.26411  1.000 41.05451 ? 1108 HOH A O   1 
HETATM 4968 O O   . HOH EB 5 .   ? -35.28852 -2.66343  -2.21802  1.000 58.96436 ? 1109 HOH A O   1 
HETATM 4969 O O   . HOH EB 5 .   ? -8.82851  6.04504   38.00886  1.000 29.14861 ? 1110 HOH A O   1 
HETATM 4970 O O   . HOH EB 5 .   ? 3.61974   -23.50687 55.47166  1.000 30.64545 ? 1111 HOH A O   1 
HETATM 4971 O O   . HOH EB 5 .   ? -29.89755 -15.46665 35.56708  1.000 51.07769 ? 1112 HOH A O   1 
HETATM 4972 O O   . HOH EB 5 .   ? -29.04564 14.04244  -5.72642  1.000 39.44782 ? 1113 HOH A O   1 
HETATM 4973 O O   . HOH EB 5 .   ? 15.04290  -17.26002 39.03853  1.000 26.92435 ? 1114 HOH A O   1 
HETATM 4974 O O   . HOH EB 5 .   ? -17.96703 -35.28709 49.00204  1.000 28.17357 ? 1115 HOH A O   1 
HETATM 4975 O O   . HOH EB 5 .   ? 1.46779   -21.63496 38.81901  1.000 27.36874 ? 1116 HOH A O   1 
HETATM 4976 O O   . HOH EB 5 .   ? -13.04727 5.00255   -9.30158  1.000 28.38363 ? 1117 HOH A O   1 
HETATM 4977 O O   . HOH EB 5 .   ? -28.81182 -32.92059 32.55282  1.000 30.78134 ? 1118 HOH A O   1 
HETATM 4978 O O   . HOH EB 5 .   ? -14.88789 -8.15092  49.92950  1.000 29.02355 ? 1119 HOH A O   1 
HETATM 4979 O O   . HOH EB 5 .   ? -23.20945 13.92760  7.79502   1.000 61.48559 ? 1120 HOH A O   1 
HETATM 4980 O O   . HOH EB 5 .   ? 8.35316   4.68398   32.92186  1.000 32.07659 ? 1121 HOH A O   1 
HETATM 4981 O O   . HOH EB 5 .   ? -23.50887 -25.78495 47.46721  1.000 49.63273 ? 1122 HOH A O   1 
HETATM 4982 O O   . HOH EB 5 .   ? -16.60752 -42.21899 19.50092  1.000 27.29599 ? 1123 HOH A O   1 
HETATM 4983 O O   . HOH EB 5 .   ? -20.23173 -25.58611 8.46356   1.000 47.56780 ? 1124 HOH A O   1 
HETATM 4984 O O   . HOH EB 5 .   ? 21.17831  -8.01000  40.55165  1.000 28.44972 ? 1125 HOH A O   1 
HETATM 4985 O O   . HOH EB 5 .   ? -32.62147 -18.36358 34.94911  1.000 33.22082 ? 1126 HOH A O   1 
HETATM 4986 O O   . HOH EB 5 .   ? 6.53231   -22.00640 19.36095  1.000 48.48438 ? 1127 HOH A O   1 
HETATM 4987 O O   . HOH EB 5 .   ? -29.75400 -7.31331  -7.23649  1.000 50.79497 ? 1128 HOH A O   1 
HETATM 4988 O O   . HOH EB 5 .   ? 19.00854  -19.32759 41.82591  1.000 36.99534 ? 1129 HOH A O   1 
HETATM 4989 O O   . HOH EB 5 .   ? 1.00858   -33.33240 39.57319  1.000 27.31192 ? 1130 HOH A O   1 
HETATM 4990 O O   . HOH EB 5 .   ? -8.68504  -9.26989  50.12845  1.000 34.53263 ? 1131 HOH A O   1 
HETATM 4991 O O   . HOH EB 5 .   ? 12.77905  -21.23771 46.48259  1.000 44.63800 ? 1132 HOH A O   1 
HETATM 4992 O O   . HOH EB 5 .   ? 5.99876   6.57112   30.97193  1.000 46.63707 ? 1133 HOH A O   1 
HETATM 4993 O O   . HOH EB 5 .   ? 20.14053  -20.62849 39.59074  1.000 27.64109 ? 1134 HOH A O   1 
HETATM 4994 O O   . HOH EB 5 .   ? -28.52046 -26.89896 43.63138  1.000 35.12977 ? 1135 HOH A O   1 
HETATM 4995 O O   . HOH EB 5 .   ? -28.04021 -21.58352 22.56261  1.000 46.76074 ? 1136 HOH A O   1 
HETATM 4996 O O   . HOH EB 5 .   ? -9.23503  7.46576   40.80763  1.000 49.05975 ? 1137 HOH A O   1 
HETATM 4997 O O   . HOH EB 5 .   ? 8.63438   3.24137   25.79517  1.000 27.68199 ? 1138 HOH A O   1 
HETATM 4998 O O   . HOH EB 5 .   ? -16.58815 -2.95947  45.99600  1.000 37.63446 ? 1139 HOH A O   1 
HETATM 4999 O O   . HOH EB 5 .   ? 7.27831   -22.86727 51.40607  1.000 42.02149 ? 1140 HOH A O   1 
HETATM 5000 O O   . HOH EB 5 .   ? 7.44760   -6.04083  13.62936  1.000 29.18586 ? 1141 HOH A O   1 
HETATM 5001 O O   . HOH EB 5 .   ? -9.94138  7.87651   22.90802  1.000 56.91550 ? 1142 HOH A O   1 
HETATM 5002 O O   . HOH EB 5 .   ? 3.52152   -12.03423 11.52752  1.000 19.94387 ? 1143 HOH A O   1 
HETATM 5003 O O   . HOH EB 5 .   ? -0.55764  -23.00057 53.77697  1.000 30.26365 ? 1144 HOH A O   1 
HETATM 5004 O O   . HOH EB 5 .   ? -5.63793  -40.55233 26.97936  1.000 32.67853 ? 1145 HOH A O   1 
HETATM 5005 O O   . HOH EB 5 .   ? -8.741    -23.656   7.168     1.000 41.88436 ? 1146 HOH A O   1 
HETATM 5006 O O   . HOH EB 5 .   ? 2.12898   -24.54968 42.72079  1.000 27.80239 ? 1147 HOH A O   1 
HETATM 5007 O O   . HOH EB 5 .   ? 21.21150  -7.38828  43.19181  1.000 39.75262 ? 1148 HOH A O   1 
HETATM 5008 O O   . HOH EB 5 .   ? -18.38986 -22.15496 54.44621  1.000 48.53214 ? 1149 HOH A O   1 
HETATM 5009 O O   . HOH EB 5 .   ? 9.02482   -27.95908 40.38113  1.000 48.79739 ? 1150 HOH A O   1 
HETATM 5010 O O   . HOH EB 5 .   ? -27.85478 -17.44609 22.11760  1.000 41.33038 ? 1151 HOH A O   1 
HETATM 5011 O O   . HOH EB 5 .   ? 2.05238   -24.09680 59.22559  1.000 45.55161 ? 1152 HOH A O   1 
HETATM 5012 O O   . HOH EB 5 .   ? 1.25929   -6.67697  29.54242  1.000 20.67401 ? 1153 HOH A O   1 
HETATM 5013 O O   . HOH EB 5 .   ? -23.69511 -37.22560 38.65552  1.000 40.19255 ? 1154 HOH A O   1 
HETATM 5014 O O   . HOH EB 5 .   ? 7.78980   -30.34342 50.72529  1.000 47.79617 ? 1155 HOH A O   1 
HETATM 5015 O O   . HOH EB 5 .   ? 2.52492   -30.53273 25.30814  1.000 48.88755 ? 1156 HOH A O   1 
HETATM 5016 O O   . HOH EB 5 .   ? -19.86956 -16.33483 12.89326  1.000 21.31568 ? 1157 HOH A O   1 
HETATM 5017 O O   . HOH EB 5 .   ? 17.63872  -5.72190  20.10286  1.000 31.07023 ? 1158 HOH A O   1 
HETATM 5018 O O   . HOH EB 5 .   ? -11.44724 7.50569   42.29917  1.000 37.71737 ? 1159 HOH A O   1 
HETATM 5019 O O   . HOH EB 5 .   ? -10.15491 -41.66319 33.31297  1.000 35.81983 ? 1160 HOH A O   1 
HETATM 5020 O O   . HOH EB 5 .   ? -12.23560 -12.17084 54.78920  1.000 28.66739 ? 1161 HOH A O   1 
HETATM 5021 O O   . HOH EB 5 .   ? 2.73823   -19.27522 42.36149  1.000 22.84910 ? 1162 HOH A O   1 
HETATM 5022 O O   . HOH EB 5 .   ? -10.18684 -42.06825 46.88038  1.000 36.17821 ? 1163 HOH A O   1 
HETATM 5023 O O   . HOH EB 5 .   ? -30.20317 -21.07900 27.18907  1.000 34.11387 ? 1164 HOH A O   1 
HETATM 5024 O O   . HOH EB 5 .   ? 17.505    -12.010   17.411    1.000 46.41103 ? 1165 HOH A O   1 
HETATM 5025 O O   . HOH EB 5 .   ? 1.38918   -27.06044 19.98824  1.000 35.32376 ? 1166 HOH A O   1 
HETATM 5026 O O   . HOH EB 5 .   ? -22.19156 12.49934  1.93536   1.000 48.10097 ? 1167 HOH A O   1 
HETATM 5027 O O   . HOH EB 5 .   ? 19.44161  -10.04417 16.68741  1.000 53.71976 ? 1168 HOH A O   1 
HETATM 5028 O O   . HOH EB 5 .   ? -20.57508 11.98197  0.05754   1.000 44.56608 ? 1169 HOH A O   1 
HETATM 5029 O O   . HOH EB 5 .   ? -19.77002 -36.99855 12.03383  1.000 39.27472 ? 1170 HOH A O   1 
HETATM 5030 O O   . HOH EB 5 .   ? -21.54484 -2.98387  36.68065  1.000 42.65953 ? 1171 HOH A O   1 
HETATM 5031 O O   . HOH EB 5 .   ? -30.68682 -34.73808 38.45975  1.000 40.62489 ? 1172 HOH A O   1 
HETATM 5032 O O   . HOH EB 5 .   ? 1.70314   -5.59502  21.01567  1.000 20.14600 ? 1173 HOH A O   1 
HETATM 5033 O O   . HOH EB 5 .   ? -24.78401 11.95709  -0.72888  1.000 40.88447 ? 1174 HOH A O   1 
HETATM 5034 O O   . HOH EB 5 .   ? 0.32215   -39.33177 49.06838  1.000 60.69966 ? 1175 HOH A O   1 
HETATM 5035 O O   . HOH EB 5 .   ? -28.47078 -14.59400 26.48575  1.000 57.23881 ? 1176 HOH A O   1 
HETATM 5036 O O   . HOH EB 5 .   ? -35.176   -31.568   33.544    1.000 31.67725 ? 1177 HOH A O   1 
HETATM 5037 O O   . HOH EB 5 .   ? -35.25498 -22.56660 33.42754  1.000 35.97316 ? 1178 HOH A O   1 
HETATM 5038 O O   . HOH EB 5 .   ? -25.36869 -11.34551 34.23554  1.000 47.58796 ? 1179 HOH A O   1 
HETATM 5039 O O   . HOH EB 5 .   ? -9.97754  -6.79323  49.89316  1.000 34.75368 ? 1180 HOH A O   1 
HETATM 5040 O O   . HOH EB 5 .   ? -16.01284 -41.54375 42.30629  1.000 48.39952 ? 1181 HOH A O   1 
HETATM 5041 O O   . HOH EB 5 .   ? 0.15556   -8.91420  50.07372  1.000 21.55329 ? 1182 HOH A O   1 
HETATM 5042 O O   . HOH EB 5 .   ? -7.33307  -40.83617 16.95815  1.000 40.30893 ? 1183 HOH A O   1 
HETATM 5043 O O   . HOH EB 5 .   ? -33.17333 -23.95772 32.00891  1.000 28.33227 ? 1184 HOH A O   1 
HETATM 5044 O O   . HOH EB 5 .   ? -26.48804 -13.56909 40.80976  1.000 53.40132 ? 1185 HOH A O   1 
HETATM 5045 O O   . HOH EB 5 .   ? -23.67899 -8.34206  16.57315  1.000 33.08994 ? 1186 HOH A O   1 
HETATM 5046 O O   . HOH EB 5 .   ? -22.32718 -5.22840  29.43226  1.000 40.37169 ? 1187 HOH A O   1 
HETATM 5047 O O   . HOH EB 5 .   ? -17.48738 11.36960  1.17024   1.000 52.66456 ? 1188 HOH A O   1 
HETATM 5048 O O   . HOH EB 5 .   ? -13.27171 -14.19026 2.86407   1.000 22.46837 ? 1189 HOH A O   1 
HETATM 5049 O O   . HOH EB 5 .   ? -34.08386 3.60284   -4.57552  1.000 46.73851 ? 1190 HOH A O   1 
HETATM 5050 O O   . HOH EB 5 .   ? 3.40331   -18.78536 39.61862  1.000 21.42035 ? 1191 HOH A O   1 
HETATM 5051 O O   . HOH EB 5 .   ? -24.18867 -4.14658  15.93327  1.000 53.32423 ? 1192 HOH A O   1 
HETATM 5052 O O   . HOH EB 5 .   ? -16.43289 11.52089  -3.01963  1.000 48.00434 ? 1193 HOH A O   1 
HETATM 5053 O O   . HOH EB 5 .   ? -8.22968  -44.07966 37.97214  1.000 53.50290 ? 1194 HOH A O   1 
HETATM 5054 O O   . HOH EB 5 .   ? 3.90010   -27.70814 58.17686  1.000 43.39981 ? 1195 HOH A O   1 
HETATM 5055 O O   . HOH EB 5 .   ? 1.862     -6.026    49.102    1.000 34.50484 ? 1196 HOH A O   1 
HETATM 5056 O O   . HOH EB 5 .   ? 18.22375  -12.47679 48.69098  1.000 38.94707 ? 1197 HOH A O   1 
HETATM 5057 O O   . HOH EB 5 .   ? 7.099     -25.471   55.057    1.000 44.19016 ? 1198 HOH A O   1 
HETATM 5058 O O   . HOH EB 5 .   ? -15.18854 -32.90987 52.36890  1.000 34.67461 ? 1199 HOH A O   1 
HETATM 5059 O O   . HOH EB 5 .   ? 16.85227  -3.14856  20.92446  1.000 49.12819 ? 1200 HOH A O   1 
HETATM 5060 O O   . HOH EB 5 .   ? 8.51589   -10.95707 17.55138  1.000 35.83874 ? 1201 HOH A O   1 
HETATM 5061 O O   . HOH EB 5 .   ? -9.466    3.599     -7.717    1.000 46.63170 ? 1202 HOH A O   1 
HETATM 5062 O O   . HOH EB 5 .   ? -28.64693 10.27257  7.82772   1.000 53.61811 ? 1203 HOH A O   1 
HETATM 5063 O O   . HOH EB 5 .   ? -28.17695 -2.91725  -9.73081  1.000 45.43758 ? 1204 HOH A O   1 
HETATM 5064 O O   . HOH EB 5 .   ? -0.95230  -6.12824  3.05905   1.000 42.14064 ? 1205 HOH A O   1 
HETATM 5065 O O   . HOH EB 5 .   ? -16.38859 -29.07868 8.78910   1.000 36.79185 ? 1206 HOH A O   1 
HETATM 5066 O O   . HOH EB 5 .   ? -14.87407 -6.00033  48.64904  1.000 49.93119 ? 1207 HOH A O   1 
HETATM 5067 O O   . HOH EB 5 .   ? -6.05994  -44.37930 29.00632  1.000 50.85777 ? 1208 HOH A O   1 
HETATM 5068 O O   . HOH EB 5 .   ? -0.34916  8.55725   32.26644  1.000 48.02084 ? 1209 HOH A O   1 
HETATM 5069 O O   . HOH EB 5 .   ? -9.39407  -20.53710 5.01175   1.000 40.75428 ? 1210 HOH A O   1 
HETATM 5070 O O   . HOH EB 5 .   ? -21.50098 -18.50435 12.42111  1.000 33.91823 ? 1211 HOH A O   1 
HETATM 5071 O O   . HOH EB 5 .   ? -21.14676 -4.99572  18.91692  1.000 41.21409 ? 1212 HOH A O   1 
HETATM 5072 O O   . HOH EB 5 .   ? 22.71811  -10.22790 39.70526  1.000 38.48925 ? 1213 HOH A O   1 
HETATM 5073 O O   . HOH EB 5 .   ? -10.04254 -46.68993 26.09474  1.000 52.94688 ? 1214 HOH A O   1 
HETATM 5074 O O   . HOH EB 5 .   ? -0.41784  -6.62421  55.20857  1.000 44.27668 ? 1215 HOH A O   1 
HETATM 5075 O O   . HOH EB 5 .   ? 6.57692   -30.96434 48.35622  1.000 57.47031 ? 1216 HOH A O   1 
HETATM 5076 O O   . HOH EB 5 .   ? -7.49337  -32.94385 53.32717  1.000 55.33847 ? 1217 HOH A O   1 
HETATM 5077 O O   . HOH EB 5 .   ? -30.18062 10.90379  -14.39022 1.000 51.47632 ? 1218 HOH A O   1 
HETATM 5078 O O   . HOH EB 5 .   ? -20.17503 0.32220   23.27555  1.000 55.27753 ? 1219 HOH A O   1 
HETATM 5079 O O   . HOH EB 5 .   ? 12.59332  -29.99446 25.35413  1.000 52.23657 ? 1220 HOH A O   1 
HETATM 5080 O O   . HOH EB 5 .   ? -27.11041 -28.94494 43.05721  1.000 52.68984 ? 1221 HOH A O   1 
HETATM 5081 O O   . HOH EB 5 .   ? 6.73542   -9.87289  14.66453  1.000 42.79246 ? 1222 HOH A O   1 
HETATM 5082 O O   . HOH EB 5 .   ? -24.44705 -6.36192  4.40298   1.000 45.07293 ? 1223 HOH A O   1 
HETATM 5083 O O   . HOH EB 5 .   ? 3.11186   -30.71509 39.52689  1.000 55.66463 ? 1224 HOH A O   1 
HETATM 5084 O O   . HOH EB 5 .   ? 19.57818  -11.95534 20.70838  0.653 28.93238 ? 1225 HOH A O   1 
HETATM 5085 O O   . HOH EB 5 .   ? -6.56778  -3.79088  48.28092  1.000 31.89971 ? 1226 HOH A O   1 
HETATM 5086 O O   . HOH EB 5 .   ? -24.08224 -5.90695  8.90182   1.000 46.27595 ? 1227 HOH A O   1 
HETATM 5087 O O   . HOH EB 5 .   ? 0.71564   -37.99520 43.74837  1.000 47.15369 ? 1228 HOH A O   1 
HETATM 5088 O O   . HOH EB 5 .   ? 0.71879   -23.58575 30.06519  1.000 51.10159 ? 1229 HOH A O   1 
HETATM 5089 O O   . HOH EB 5 .   ? -5.62313  -42.93443 41.67640  1.000 54.19515 ? 1230 HOH A O   1 
HETATM 5090 O O   . HOH EB 5 .   ? -23.85665 -4.13272  39.76997  1.000 57.73783 ? 1231 HOH A O   1 
HETATM 5091 O O   . HOH EB 5 .   ? -28.04658 -15.44696 42.86796  1.000 50.35459 ? 1232 HOH A O   1 
HETATM 5092 O O   . HOH EB 5 .   ? 0.84898   -5.84491  4.49399   1.000 44.33581 ? 1233 HOH A O   1 
HETATM 5093 O O   . HOH EB 5 .   ? -24.01686 -41.91777 25.60050  1.000 38.59771 ? 1234 HOH A O   1 
HETATM 5094 O O   . HOH EB 5 .   ? -14.41256 1.35991   19.92316  1.000 53.72289 ? 1235 HOH A O   1 
HETATM 5095 O O   . HOH EB 5 .   ? -7.46462  -40.50529 50.69770  1.000 46.91132 ? 1236 HOH A O   1 
HETATM 5096 O O   . HOH EB 5 .   ? 3.539     -19.914   54.386    1.000 43.66454 ? 1237 HOH A O   1 
HETATM 5097 O O   . HOH EB 5 .   ? -31.22166 13.80203  2.85079   1.000 50.50851 ? 1238 HOH A O   1 
HETATM 5098 O O   . HOH EB 5 .   ? -3.05295  -15.96524 20.95382  1.000 19.55709 ? 1239 HOH A O   1 
HETATM 5099 O O   . HOH EB 5 .   ? -27.88361 9.12689   -14.77792 1.000 52.09179 ? 1240 HOH A O   1 
HETATM 5100 O O   . HOH EB 5 .   ? -6.97065  -23.35046 57.29718  1.000 46.40796 ? 1241 HOH A O   1 
HETATM 5101 O O   . HOH EB 5 .   ? -3.10768  -29.65021 33.48485  1.000 25.42458 ? 1242 HOH A O   1 
HETATM 5102 O O   . HOH EB 5 .   ? 18.11341  -0.52072  38.71534  1.000 40.02059 ? 1243 HOH A O   1 
HETATM 5103 O O   . HOH EB 5 .   ? -21.50718 -17.31816 55.64852  1.000 56.26164 ? 1244 HOH A O   1 
HETATM 5104 O O   . HOH EB 5 .   ? 20.98032  -8.84630  18.23790  1.000 48.78742 ? 1245 HOH A O   1 
HETATM 5105 O O   . HOH EB 5 .   ? 23.92818  -1.35778  32.58729  1.000 54.74432 ? 1246 HOH A O   1 
HETATM 5106 O O   . HOH EB 5 .   ? -10.28613 -36.91447 13.20169  1.000 37.11193 ? 1247 HOH A O   1 
HETATM 5107 O O   . HOH EB 5 .   ? -21.28982 10.34304  10.06669  1.000 50.58915 ? 1248 HOH A O   1 
HETATM 5108 O O   . HOH EB 5 .   ? -20.48851 12.15464  -5.26311  1.000 41.50523 ? 1249 HOH A O   1 
HETATM 5109 O O   . HOH EB 5 .   ? 0.85460   -21.54664 36.21498  1.000 37.67121 ? 1250 HOH A O   1 
HETATM 5110 O O   . HOH EB 5 .   ? 8.88151   0.25151   14.47840  1.000 53.57414 ? 1251 HOH A O   1 
HETATM 5111 O O   . HOH EB 5 .   ? -17.79359 8.60359   42.19849  1.000 54.52247 ? 1252 HOH A O   1 
HETATM 5112 O O   . HOH EB 5 .   ? -6.362    -21.390   1.931     1.000 44.20118 ? 1253 HOH A O   1 
HETATM 5113 O O   . HOH EB 5 .   ? -13.62513 -44.77033 23.11860  1.000 41.24540 ? 1254 HOH A O   1 
HETATM 5114 O O   . HOH EB 5 .   ? 1.36725   11.27273  23.21741  1.000 58.37614 ? 1255 HOH A O   1 
HETATM 5115 O O   . HOH EB 5 .   ? -25.00275 -18.28242 15.59312  1.000 29.27310 ? 1256 HOH A O   1 
HETATM 5116 O O   . HOH EB 5 .   ? -18.96891 -20.36602 7.87579   1.000 50.35130 ? 1257 HOH A O   1 
HETATM 5117 O O   . HOH EB 5 .   ? -31.57903 -0.23517  10.25090  1.000 50.09950 ? 1258 HOH A O   1 
HETATM 5118 O O   . HOH EB 5 .   ? -19.12883 -8.07826  5.30908   1.000 37.25237 ? 1259 HOH A O   1 
HETATM 5119 O O   . HOH EB 5 .   ? 15.93602  -5.28985  18.20266  1.000 49.67398 ? 1260 HOH A O   1 
HETATM 5120 O O   . HOH EB 5 .   ? 0.41327   -20.28291 43.65589  1.000 23.15384 ? 1261 HOH A O   1 
HETATM 5121 O O   . HOH EB 5 .   ? -9.287    1.918     -4.046    1.000 42.59781 ? 1262 HOH A O   1 
HETATM 5122 O O   . HOH EB 5 .   ? -21.00805 2.38804   28.35672  1.000 56.86418 ? 1263 HOH A O   1 
HETATM 5123 O O   . HOH EB 5 .   ? 20.91783  -6.25003  19.87666  1.000 57.89284 ? 1264 HOH A O   1 
HETATM 5124 O O   . HOH EB 5 .   ? -0.17609  -24.89900 18.76911  1.000 31.78277 ? 1265 HOH A O   1 
HETATM 5125 O O   . HOH EB 5 .   ? -6.73687  9.85126   36.32545  1.000 44.84683 ? 1266 HOH A O   1 
HETATM 5126 O O   . HOH EB 5 .   ? -12.38602 5.84207   -1.78778  1.000 50.55133 ? 1267 HOH A O   1 
HETATM 5127 O O   . HOH EB 5 .   ? -6.94207  10.70004  24.36252  1.000 55.34284 ? 1268 HOH A O   1 
HETATM 5128 O O   . HOH EB 5 .   ? -8.99065  8.63943   36.97982  1.000 40.03278 ? 1269 HOH A O   1 
HETATM 5129 O O   . HOH EB 5 .   ? -16.02250 -21.44997 53.58623  1.000 35.51272 ? 1270 HOH A O   1 
HETATM 5130 O O   . HOH EB 5 .   ? -17.96731 -28.54200 52.60563  1.000 38.17885 ? 1271 HOH A O   1 
HETATM 5131 O O   . HOH EB 5 .   ? -23.23094 -1.49730  30.00869  1.000 56.10571 ? 1272 HOH A O   1 
HETATM 5132 O O   . HOH EB 5 .   ? -20.99605 -18.79223 9.40852   1.000 48.15033 ? 1273 HOH A O   1 
HETATM 5133 O O   . HOH EB 5 .   ? -20.27018 10.95539  8.04265   1.000 63.93020 ? 1274 HOH A O   1 
HETATM 5134 O O   . HOH EB 5 .   ? -31.31043 -22.04109 32.20472  1.000 45.56733 ? 1275 HOH A O   1 
HETATM 5135 O O   . HOH EB 5 .   ? -25.21808 -7.72509  -4.13328  1.000 54.05403 ? 1276 HOH A O   1 
HETATM 5136 O O   . HOH EB 5 .   ? -2.92557  -15.97550 54.01015  1.000 54.68725 ? 1277 HOH A O   1 
HETATM 5137 O O   . HOH EB 5 .   ? -11.32919 -4.12027  48.83169  1.000 37.15598 ? 1278 HOH A O   1 
HETATM 5138 O O   . HOH EB 5 .   ? -3.40222  -44.08814 37.41991  1.000 58.08488 ? 1279 HOH A O   1 
HETATM 5139 O O   . HOH EB 5 .   ? 7.53970   -7.74242  11.79239  1.000 54.64653 ? 1280 HOH A O   1 
HETATM 5140 O O   . HOH EB 5 .   ? 1.449     -6.982    53.472    1.000 42.71179 ? 1281 HOH A O   1 
HETATM 5141 O O   . HOH EB 5 .   ? -15.50039 -32.55302 14.49786  1.000 27.11077 ? 1282 HOH A O   1 
HETATM 5142 O O   . HOH EB 5 .   ? -15.53790 4.89000   24.14550  1.000 55.17121 ? 1283 HOH A O   1 
HETATM 5143 O O   . HOH EB 5 .   ? -18.37799 -39.71957 47.38326  1.000 55.40520 ? 1284 HOH A O   1 
HETATM 5144 O O   . HOH EB 5 .   ? -28.83894 -16.57980 33.07800  1.000 41.73170 ? 1285 HOH A O   1 
HETATM 5145 O O   . HOH EB 5 .   ? -20.18317 -38.42993 47.02003  1.000 55.02772 ? 1286 HOH A O   1 
HETATM 5146 O O   . HOH EB 5 .   ? -24.66737 -5.09689  26.07633  1.000 40.09834 ? 1287 HOH A O   1 
HETATM 5147 O O   . HOH EB 5 .   ? -16.27035 5.45202   6.09901   1.000 53.01146 ? 1288 HOH A O   1 
HETATM 5148 O O   . HOH EB 5 .   ? -8.54159  7.12278   20.16717  1.000 58.07355 ? 1289 HOH A O   1 
HETATM 5149 O O   . HOH EB 5 .   ? -23.88377 -22.37226 50.23678  1.000 48.58435 ? 1290 HOH A O   1 
HETATM 5150 O O   . HOH EB 5 .   ? -4.33361  -43.36223 49.63082  1.000 57.88377 ? 1291 HOH A O   1 
HETATM 5151 O O   . HOH EB 5 .   ? -26.39080 -9.08815  -7.27217  1.000 40.92569 ? 1292 HOH A O   1 
HETATM 5152 O O   . HOH EB 5 .   ? -15.53893 -28.20013 53.14908  1.000 33.57888 ? 1293 HOH A O   1 
HETATM 5153 O O   . HOH EB 5 .   ? -8.91930  -43.01479 49.07142  1.000 52.22691 ? 1294 HOH A O   1 
HETATM 5154 O O   . HOH EB 5 .   ? -28.91919 13.07057  7.39866   1.000 58.01952 ? 1295 HOH A O   1 
HETATM 5155 O O   . HOH EB 5 .   ? -25.93022 -15.99019 17.25736  1.000 39.87808 ? 1296 HOH A O   1 
HETATM 5156 O O   . HOH EB 5 .   ? 9.05460   -3.18661  14.53178  1.000 54.36156 ? 1297 HOH A O   1 
HETATM 5157 O O   . HOH EB 5 .   ? -14.21198 -1.98158  46.66651  1.000 37.43956 ? 1298 HOH A O   1 
HETATM 5158 O O   . HOH EB 5 .   ? 23.46764  -1.07825  35.08889  1.000 43.91340 ? 1299 HOH A O   1 
HETATM 5159 O O   . HOH EB 5 .   ? -30.16476 1.64235   -10.66386 1.000 49.83945 ? 1300 HOH A O   1 
HETATM 5160 O O   . HOH EB 5 .   ? -12.42544 -27.16781 7.36753   1.000 43.15313 ? 1301 HOH A O   1 
HETATM 5161 O O   . HOH EB 5 .   ? -19.85985 -43.08599 21.48621  1.000 35.33617 ? 1302 HOH A O   1 
HETATM 5162 O O   . HOH EB 5 .   ? 6.30937   -1.87907  12.52746  1.000 53.93227 ? 1303 HOH A O   1 
HETATM 5163 O O   . HOH EB 5 .   ? -13.68975 -42.36598 41.43787  1.000 51.94604 ? 1304 HOH A O   1 
HETATM 5164 O O   . HOH EB 5 .   ? -6.21087  -7.99278  53.61584  1.000 56.71497 ? 1305 HOH A O   1 
HETATM 5165 O O   . HOH EB 5 .   ? -34.670   -16.385   40.147    1.000 45.35165 ? 1306 HOH A O   1 
HETATM 5166 O O   . HOH EB 5 .   ? -10.00611 -10.75514 54.53141  1.000 50.49104 ? 1307 HOH A O   1 
HETATM 5167 O O   . HOH EB 5 .   ? 21.414    -4.209    42.097    1.000 48.02471 ? 1308 HOH A O   1 
HETATM 5168 O O   . HOH EB 5 .   ? -12.70317 -42.25702 18.04281  1.000 38.72574 ? 1309 HOH A O   1 
HETATM 5169 O O   . HOH EB 5 .   ? -14.44736 -18.65054 56.78502  1.000 42.75836 ? 1310 HOH A O   1 
HETATM 5170 O O   . HOH EB 5 .   ? -25.76430 14.11054  6.62158   1.000 55.10781 ? 1311 HOH A O   1 
HETATM 5171 O O   . HOH EB 5 .   ? 18.34959  -29.13407 34.31839  1.000 50.72660 ? 1312 HOH A O   1 
HETATM 5172 O O   . HOH EB 5 .   ? -8.05759  -1.45847  45.10500  1.000 30.74688 ? 1313 HOH A O   1 
HETATM 5173 O O   . HOH EB 5 .   ? 4.57888   -9.13433  9.70565   1.000 51.42732 ? 1314 HOH A O   1 
HETATM 5174 O O   . HOH EB 5 .   ? 11.79634  3.53832   20.31611  1.000 53.25585 ? 1315 HOH A O   1 
HETATM 5175 O O   . HOH EB 5 .   ? -11.53853 -23.53144 4.31548   1.000 46.48893 ? 1316 HOH A O   1 
HETATM 5176 O O   . HOH EB 5 .   ? 4.41007   -33.21892 48.18428  1.000 55.25931 ? 1317 HOH A O   1 
HETATM 5177 O O   . HOH EB 5 .   ? -10.29416 -0.15961  4.21075   1.000 45.88261 ? 1318 HOH A O   1 
HETATM 5178 O O   . HOH EB 5 .   ? -25.41568 -21.08419 48.82272  1.000 50.70887 ? 1319 HOH A O   1 
HETATM 5179 O O   . HOH EB 5 .   ? 12.52723  -23.85109 46.53069  1.000 46.27315 ? 1320 HOH A O   1 
HETATM 5180 O O   . HOH EB 5 .   ? 24.68802  -12.93374 37.74021  1.000 35.70596 ? 1321 HOH A O   1 
HETATM 5181 O O   . HOH EB 5 .   ? 0.47199   -39.58763 45.38900  1.000 55.98670 ? 1322 HOH A O   1 
HETATM 5182 O O   . HOH EB 5 .   ? -17.32480 -7.10402  6.60193   1.000 37.28982 ? 1323 HOH A O   1 
HETATM 5183 O O   . HOH EB 5 .   ? -16.47731 4.21874   32.18990  1.000 45.21020 ? 1324 HOH A O   1 
HETATM 5184 O O   . HOH EB 5 .   ? -27.29235 14.89084  9.80966   1.000 57.73126 ? 1325 HOH A O   1 
HETATM 5185 O O   . HOH EB 5 .   ? -5.95495  -31.53125 55.35642  1.000 55.05148 ? 1326 HOH A O   1 
HETATM 5186 O O   . HOH EB 5 .   ? 22.02427  -17.32842 39.84645  1.000 53.00116 ? 1327 HOH A O   1 
HETATM 5187 O O   . HOH EB 5 .   ? 25.17538  -9.23932  40.25175  1.000 48.03199 ? 1328 HOH A O   1 
HETATM 5188 O O   . HOH EB 5 .   ? -33.51243 6.71511   2.05746   1.000 43.42924 ? 1329 HOH A O   1 
HETATM 5189 O O   . HOH EB 5 .   ? 0.73007   -22.43113 56.04616  1.000 39.22117 ? 1330 HOH A O   1 
HETATM 5190 O O   . HOH EB 5 .   ? -19.30793 7.90653   47.11842  1.000 57.22127 ? 1331 HOH A O   1 
HETATM 5191 O O   . HOH EB 5 .   ? -26.46056 -11.26374 19.52413  1.000 51.84301 ? 1332 HOH A O   1 
HETATM 5192 O O   . HOH EB 5 .   ? 23.411    -22.327   36.428    1.000 33.92155 ? 1333 HOH A O   1 
HETATM 5193 O O   . HOH EB 5 .   ? -36.12419 2.91119   0.31268   1.000 56.21722 ? 1334 HOH A O   1 
HETATM 5194 O O   . HOH EB 5 .   ? -24.85759 -6.80164  14.86419  1.000 50.23915 ? 1335 HOH A O   1 
HETATM 5195 O O   . HOH EB 5 .   ? -15.82148 -40.83479 12.52993  1.000 52.40417 ? 1336 HOH A O   1 
HETATM 5196 O O   . HOH EB 5 .   ? -29.15304 -4.97413  0.84503   1.000 53.42836 ? 1337 HOH A O   1 
HETATM 5197 O O   . HOH EB 5 .   ? -6.56077  -41.83340 20.03804  1.000 41.77225 ? 1338 HOH A O   1 
HETATM 5198 O O   . HOH EB 5 .   ? -25.99489 -36.40805 35.29390  1.000 41.62297 ? 1339 HOH A O   1 
HETATM 5199 O O   . HOH EB 5 .   ? -35.05658 0.97215   7.87329   1.000 59.35382 ? 1340 HOH A O   1 
HETATM 5200 O O   . HOH EB 5 .   ? -17.03185 -38.54838 11.29462  1.000 53.80101 ? 1341 HOH A O   1 
HETATM 5201 O O   . HOH EB 5 .   ? -24.67419 -37.06990 41.19542  1.000 46.37370 ? 1342 HOH A O   1 
HETATM 5202 O O   . HOH EB 5 .   ? -1.86337  -2.98567  44.13290  1.000 32.38798 ? 1343 HOH A O   1 
HETATM 5203 O O   . HOH EB 5 .   ? -31.72173 12.38050  -12.43115 1.000 51.74876 ? 1344 HOH A O   1 
HETATM 5204 O O   . HOH EB 5 .   ? -29.30036 5.95826   -13.74940 1.000 55.23904 ? 1345 HOH A O   1 
HETATM 5205 O O   . HOH EB 5 .   ? -2.71886  -1.49150  47.80635  1.000 48.24922 ? 1346 HOH A O   1 
HETATM 5206 O O   . HOH EB 5 .   ? 3.07806   -28.41814 27.47569  1.000 45.68674 ? 1347 HOH A O   1 
HETATM 5207 O O   . HOH EB 5 .   ? 12.58747  -18.38607 18.15002  1.000 34.64524 ? 1348 HOH A O   1 
HETATM 5208 O O   . HOH EB 5 .   ? 3.52502   -34.34173 51.74261  1.000 54.65092 ? 1349 HOH A O   1 
HETATM 5209 O O   . HOH EB 5 .   ? -14.73115 11.83848  -1.37217  1.000 59.88454 ? 1350 HOH A O   1 
HETATM 5210 O O   . HOH EB 5 .   ? -22.13651 -43.84885 22.46586  1.000 42.49620 ? 1351 HOH A O   1 
HETATM 5211 O O   . HOH EB 5 .   ? -15.70822 -8.18142  52.63056  1.000 43.44110 ? 1352 HOH A O   1 
HETATM 5212 O O   . HOH EB 5 .   ? -5.59212  -34.17004 14.92823  1.000 43.83784 ? 1353 HOH A O   1 
HETATM 5213 O O   . HOH EB 5 .   ? -29.08890 9.83608   10.56344  1.000 54.66757 ? 1354 HOH A O   1 
HETATM 5214 O O   . HOH EB 5 .   ? -6.34849  8.11158   20.18924  1.000 52.79707 ? 1355 HOH A O   1 
HETATM 5215 O O   . HOH EB 5 .   ? -1.88820  -40.73945 46.39956  1.000 53.78123 ? 1356 HOH A O   1 
HETATM 5216 O O   . HOH EB 5 .   ? -12.58388 -42.85439 47.10622  1.000 49.47895 ? 1357 HOH A O   1 
HETATM 5217 O O   . HOH EB 5 .   ? 9.43692   4.55406   21.73288  1.000 41.29643 ? 1358 HOH A O   1 
HETATM 5218 O O   . HOH EB 5 .   ? -21.33190 -26.43056 50.64326  1.000 50.39767 ? 1359 HOH A O   1 
HETATM 5219 O O   . HOH EB 5 .   ? -25.86713 -14.35417 13.74231  1.000 50.43801 ? 1360 HOH A O   1 
HETATM 5220 O O   . HOH EB 5 .   ? 22.89045  -4.58253  28.49510  1.000 43.98812 ? 1361 HOH A O   1 
HETATM 5221 O O   . HOH EB 5 .   ? -11.82912 -22.17823 53.13303  1.000 31.83614 ? 1362 HOH A O   1 
HETATM 5222 O O   . HOH EB 5 .   ? -5.73009  -43.09946 44.10263  1.000 55.15596 ? 1363 HOH A O   1 
HETATM 5223 O O   . HOH EB 5 .   ? -9.96141  -41.75826 38.13381  1.000 44.72091 ? 1364 HOH A O   1 
HETATM 5224 O O   . HOH EB 5 .   ? -19.61657 -1.66318  35.46525  1.000 52.08329 ? 1365 HOH A O   1 
HETATM 5225 O O   . HOH EB 5 .   ? -22.97105 -7.02415  30.90879  1.000 35.59436 ? 1366 HOH A O   1 
HETATM 5226 O O   . HOH EB 5 .   ? -34.361   -15.000   38.155    1.000 61.47467 ? 1367 HOH A O   1 
HETATM 5227 O O   . HOH EB 5 .   ? -26.39672 -8.96597  25.48775  1.000 39.99315 ? 1368 HOH A O   1 
HETATM 5228 O O   . HOH EB 5 .   ? -23.42972 -15.03879 11.40611  1.000 48.39867 ? 1369 HOH A O   1 
HETATM 5229 O O   . HOH EB 5 .   ? -14.04933 -10.85405 55.82574  1.000 49.42666 ? 1370 HOH A O   1 
HETATM 5230 O O   . HOH EB 5 .   ? -28.28433 -15.10720 30.93747  1.000 43.60676 ? 1371 HOH A O   1 
HETATM 5231 O O   . HOH EB 5 .   ? -25.068   -23.548   10.106    1.000 53.50970 ? 1372 HOH A O   1 
HETATM 5232 O O   . HOH EB 5 .   ? -11.82866 11.64411  -9.95388  1.000 51.26896 ? 1373 HOH A O   1 
HETATM 5233 O O   . HOH EB 5 .   ? 27.86908  -9.74242  37.19226  1.000 40.20700 ? 1374 HOH A O   1 
HETATM 5234 O O   . HOH EB 5 .   ? -6.97154  -40.99026 31.44924  1.000 42.55392 ? 1375 HOH A O   1 
HETATM 5235 O O   . HOH EB 5 .   ? -2.74561  -34.54373 15.55422  1.000 52.14824 ? 1376 HOH A O   1 
HETATM 5236 O O   . HOH EB 5 .   ? 0.65738   -37.44535 40.71551  1.000 55.03139 ? 1377 HOH A O   1 
HETATM 5237 O O   . HOH EB 5 .   ? -27.24227 13.84925  -3.56184  1.000 39.62474 ? 1378 HOH A O   1 
HETATM 5238 O O   . HOH EB 5 .   ? -2.08843  -42.64856 35.58747  1.000 53.98153 ? 1379 HOH A O   1 
HETATM 5239 O O   . HOH EB 5 .   ? 10.30223  5.19089   30.59435  1.000 47.60478 ? 1380 HOH A O   1 
HETATM 5240 O O   . HOH EB 5 .   ? -8.43803  -43.09160 31.88050  1.000 42.48622 ? 1381 HOH A O   1 
HETATM 5241 O O   . HOH EB 5 .   ? 9.48246   -28.42777 35.64770  1.000 56.66487 ? 1382 HOH A O   1 
HETATM 5242 O O   . HOH EB 5 .   ? -30.89947 -16.61277 28.52244  1.000 56.28072 ? 1383 HOH A O   1 
HETATM 5243 O O   . HOH EB 5 .   ? -11.62334 -43.45535 19.97333  1.000 36.89944 ? 1384 HOH A O   1 
HETATM 5244 O O   . HOH EB 5 .   ? -29.98375 -20.06527 31.49994  1.000 46.84612 ? 1385 HOH A O   1 
HETATM 5245 O O   . HOH EB 5 .   ? 6.13960   -21.53706 36.36210  1.000 34.27513 ? 1386 HOH A O   1 
HETATM 5246 O O   . HOH EB 5 .   ? -5.13557  -1.88740  49.69986  1.000 48.82599 ? 1387 HOH A O   1 
HETATM 5247 O O   . HOH EB 5 .   ? -9.078    -21.094   -5.010    1.000 50.27920 ? 1388 HOH A O   1 
HETATM 5248 O O   . HOH EB 5 .   ? -24.30240 -5.29054  -0.19607  1.000 43.49336 ? 1389 HOH A O   1 
HETATM 5249 O O   . HOH EB 5 .   ? 21.05772  -0.98098  37.46161  1.000 41.77636 ? 1390 HOH A O   1 
HETATM 5250 O O   . HOH EB 5 .   ? 3.91048   -25.88049 20.66622  1.000 51.67451 ? 1391 HOH A O   1 
HETATM 5251 O O   . HOH EB 5 .   ? 5.52490   -3.40704  8.62475   1.000 48.50807 ? 1392 HOH A O   1 
HETATM 5252 O O   . HOH EB 5 .   ? 4.72872   -30.27768 23.58545  1.000 52.07747 ? 1393 HOH A O   1 
HETATM 5253 O O   . HOH EB 5 .   ? -35.50580 -26.20936 45.07672  1.000 51.44327 ? 1394 HOH A O   1 
HETATM 5254 O O   . HOH EB 5 .   ? 21.30009  -14.96940 39.39483  1.000 40.46231 ? 1395 HOH A O   1 
HETATM 5255 O O   . HOH EB 5 .   ? -9.16693  -38.13889 52.14311  1.000 49.25723 ? 1396 HOH A O   1 
HETATM 5256 O O   . HOH EB 5 .   ? -28.35252 4.24105   18.27846  1.000 53.34069 ? 1397 HOH A O   1 
HETATM 5257 O O   . HOH EB 5 .   ? -24.30519 -18.25369 12.69649  1.000 33.85035 ? 1398 HOH A O   1 
HETATM 5258 O O   . HOH EB 5 .   ? -19.15252 1.99490   17.03833  1.000 53.05437 ? 1399 HOH A O   1 
HETATM 5259 O O   . HOH EB 5 .   ? 3.78001   -33.26318 27.55953  1.000 53.28656 ? 1400 HOH A O   1 
HETATM 5260 O O   . HOH EB 5 .   ? -35.60562 4.29030   5.02276   1.000 55.89949 ? 1401 HOH A O   1 
HETATM 5261 O O   . HOH EB 5 .   ? 10.33766  6.45352   23.58166  1.000 52.69357 ? 1402 HOH A O   1 
HETATM 5262 O O   . HOH EB 5 .   ? -11.64922 -22.79177 7.03314   1.000 40.79060 ? 1403 HOH A O   1 
HETATM 5263 O O   . HOH EB 5 .   ? -25.94136 -20.70779 12.24842  1.000 29.57364 ? 1404 HOH A O   1 
HETATM 5264 O O   . HOH EB 5 .   ? 0.02332   -22.84611 43.37473  1.000 24.78375 ? 1405 HOH A O   1 
HETATM 5265 O O   . HOH EB 5 .   ? -34.16142 3.21403   9.38981   1.000 55.74445 ? 1406 HOH A O   1 
HETATM 5266 O O   . HOH EB 5 .   ? -26.67048 9.71714   14.22064  1.000 50.16623 ? 1407 HOH A O   1 
HETATM 5267 O O   . HOH EB 5 .   ? -6.48092  -5.60059  52.20206  1.000 50.80799 ? 1408 HOH A O   1 
HETATM 5268 O O   . HOH EB 5 .   ? -13.30762 -35.05904 11.08264  1.000 47.77546 ? 1409 HOH A O   1 
HETATM 5269 O O   . HOH EB 5 .   ? 2.06701   -0.91142  10.59821  1.000 46.50332 ? 1410 HOH A O   1 
HETATM 5270 O O   . HOH EB 5 .   ? -9.86870  -1.70488  47.60661  1.000 54.44724 ? 1411 HOH A O   1 
HETATM 5271 O O   . HOH EB 5 .   ? -26.31412 -2.59078  12.58738  1.000 55.66187 ? 1412 HOH A O   1 
HETATM 5272 O O   . HOH EB 5 .   ? -34.86764 5.68117   -3.25281  1.000 55.55533 ? 1413 HOH A O   1 
HETATM 5273 O O   . HOH EB 5 .   ? 2.44964   0.17432   13.82263  1.000 33.50313 ? 1414 HOH A O   1 
HETATM 5274 O O   . HOH EB 5 .   ? -3.92986  0.63091   43.92684  1.000 41.26418 ? 1415 HOH A O   1 
HETATM 5275 O O   . HOH EB 5 .   ? -9.57753  -35.94240 52.75131  1.000 50.58303 ? 1416 HOH A O   1 
HETATM 5276 O O   . HOH EB 5 .   ? -20.75085 0.05843   33.08739  1.000 42.07464 ? 1417 HOH A O   1 
HETATM 5277 O O   . HOH EB 5 .   ? -0.55343  -29.15393 34.07376  1.000 40.92519 ? 1418 HOH A O   1 
HETATM 5278 O O   . HOH EB 5 .   ? -7.60294  -44.80729 22.57855  1.000 52.42147 ? 1419 HOH A O   1 
HETATM 5279 O O   . HOH EB 5 .   ? -14.59866 -25.63393 54.07826  1.000 30.45615 ? 1420 HOH A O   1 
HETATM 5280 O O   . HOH EB 5 .   ? -7.71322  -35.35791 12.77238  1.000 48.11928 ? 1421 HOH A O   1 
HETATM 5281 O O   . HOH EB 5 .   ? -16.48063 -37.07912 49.81809  1.000 40.19288 ? 1422 HOH A O   1 
HETATM 5282 O O   . HOH EB 5 .   ? -26.89362 -13.72690 21.23237  1.000 42.62230 ? 1423 HOH A O   1 
HETATM 5283 O O   . HOH EB 5 .   ? -27.38832 -12.82362 23.80929  1.000 45.47889 ? 1424 HOH A O   1 
HETATM 5284 O O   . HOH EB 5 .   ? -3.99663  -1.78055  45.06533  1.000 32.48042 ? 1425 HOH A O   1 
HETATM 5285 O O   . HOH EB 5 .   ? 20.83237  -13.54076 33.11059  1.000 20.79725 ? 1426 HOH A O   1 
HETATM 5286 O O   . HOH EB 5 .   ? -20.66926 -19.71468 56.58207  1.000 57.70799 ? 1427 HOH A O   1 
HETATM 5287 O O   . HOH EB 5 .   ? -17.54104 -41.81332 22.17060  1.000 24.63817 ? 1428 HOH A O   1 
HETATM 5288 O O   . HOH EB 5 .   ? -11.90320 -34.55060 13.24062  1.000 25.17826 ? 1429 HOH A O   1 
HETATM 5289 O O   . HOH EB 5 .   ? -15.43713 -44.36032 19.53734  1.000 45.29076 ? 1430 HOH A O   1 
HETATM 5290 O O   . HOH EB 5 .   ? 15.48539  -0.03130  21.05528  1.000 52.35370 ? 1431 HOH A O   1 
HETATM 5291 O O   . HOH EB 5 .   ? 4.57021   -35.95439 41.76006  1.000 56.93853 ? 1432 HOH A O   1 
HETATM 5292 O O   . HOH EB 5 .   ? -15.22795 -39.63354 49.08863  1.000 49.68985 ? 1433 HOH A O   1 
HETATM 5293 O O   . HOH EB 5 .   ? -25.99406 -20.59474 16.48455  1.000 20.58342 ? 1434 HOH A O   1 
HETATM 5294 O O   . HOH EB 5 .   ? -1.73161  -43.55894 40.08338  1.000 60.08465 ? 1435 HOH A O   1 
HETATM 5295 O O   . HOH EB 5 .   ? -4.51481  12.30674  32.93229  1.000 49.57457 ? 1436 HOH A O   1 
HETATM 5296 O O   . HOH EB 5 .   ? -10.36135 -20.46710 56.89126  1.000 50.15655 ? 1437 HOH A O   1 
HETATM 5297 O O   . HOH EB 5 .   ? -6.46209  -36.83459 16.51530  1.000 38.94720 ? 1438 HOH A O   1 
HETATM 5298 O O   . HOH EB 5 .   ? 0.42353   7.01346   16.65023  1.000 53.59508 ? 1439 HOH A O   1 
HETATM 5299 O O   . HOH EB 5 .   ? -35.281   -17.854   34.613    1.000 56.73521 ? 1440 HOH A O   1 
HETATM 5300 O O   . HOH EB 5 .   ? -23.37996 -5.37514  2.22804   1.000 40.98080 ? 1441 HOH A O   1 
HETATM 5301 O O   . HOH EB 5 .   ? 1.05076   -24.23502 35.03306  1.000 56.15249 ? 1442 HOH A O   1 
HETATM 5302 O O   . HOH EB 5 .   ? 21.41135  -18.37888 42.32313  1.000 53.70982 ? 1443 HOH A O   1 
HETATM 5303 O O   . HOH EB 5 .   ? -33.70168 2.71268   -7.17419  1.000 46.30247 ? 1444 HOH A O   1 
HETATM 5304 O O   . HOH EB 5 .   ? -32.78856 -20.51911 33.87169  1.000 41.78518 ? 1445 HOH A O   1 
HETATM 5305 O O   . HOH EB 5 .   ? 0.64764   -39.13786 35.86070  1.000 54.27274 ? 1446 HOH A O   1 
HETATM 5306 O O   . HOH EB 5 .   ? -29.12235 1.93599   -15.07518 1.000 46.38821 ? 1447 HOH A O   1 
HETATM 5307 O O   . HOH EB 5 .   ? -8.23986  5.83583   17.56437  1.000 55.00844 ? 1448 HOH A O   1 
HETATM 5308 O O   . HOH EB 5 .   ? 14.93470  -30.72752 37.08471  1.000 57.14702 ? 1449 HOH A O   1 
HETATM 5309 O O   . HOH EB 5 .   ? 6.88572   -32.62969 52.26655  1.000 60.81624 ? 1450 HOH A O   1 
HETATM 5310 O O   . HOH EB 5 .   ? -19.21065 -2.77929  19.09747  1.000 42.39845 ? 1451 HOH A O   1 
HETATM 5311 O O   . HOH EB 5 .   ? 1.37193   2.80910   13.12638  1.000 50.12312 ? 1452 HOH A O   1 
HETATM 5312 O O   . HOH EB 5 .   ? 22.20913  -12.58307 40.95175  1.000 46.90606 ? 1453 HOH A O   1 
HETATM 5313 O O   . HOH EB 5 .   ? 1.10575   -24.41737 39.88252  1.000 33.90414 ? 1454 HOH A O   1 
HETATM 5314 O O   . HOH EB 5 .   ? -15.89401 2.78204   13.38176  1.000 47.38560 ? 1455 HOH A O   1 
HETATM 5315 O O   . HOH EB 5 .   ? 17.724    -20.099   45.796    1.000 51.92718 ? 1456 HOH A O   1 
HETATM 5316 O O   . HOH EB 5 .   ? -27.31116 -35.12885 31.50500  1.000 36.03045 ? 1457 HOH A O   1 
HETATM 5317 O O   . HOH EB 5 .   ? -10.43722 -16.45232 56.56375  1.000 41.74305 ? 1458 HOH A O   1 
HETATM 5318 O O   . HOH EB 5 .   ? 13.80137  -31.13822 34.26865  1.000 57.16152 ? 1459 HOH A O   1 
HETATM 5319 O O   . HOH EB 5 .   ? -7.132    -30.555   10.197    1.000 50.95043 ? 1460 HOH A O   1 
HETATM 5320 O O   . HOH EB 5 .   ? -11.52570 -22.33916 55.84119  1.000 39.66879 ? 1461 HOH A O   1 
HETATM 5321 O O   . HOH EB 5 .   ? -26.06143 -13.07137 27.69388  1.000 33.74647 ? 1462 HOH A O   1 
HETATM 5322 O O   . HOH EB 5 .   ? 25.29687  -3.48054  29.22237  1.000 56.01824 ? 1463 HOH A O   1 
HETATM 5323 O O   . HOH EB 5 .   ? -8.899    9.130     -15.222   1.000 48.05040 ? 1464 HOH A O   1 
HETATM 5324 O O   . HOH EB 5 .   ? -25.93462 -11.54965 25.43086  1.000 31.20213 ? 1465 HOH A O   1 
HETATM 5325 O O   . HOH EB 5 .   ? -11.19816 3.86413   17.42225  1.000 61.22943 ? 1466 HOH A O   1 
HETATM 5326 O O   . HOH EB 5 .   ? 20.904    -32.023   30.067    1.000 57.46700 ? 1467 HOH A O   1 
HETATM 5327 O O   . HOH EB 5 .   ? 2.03835   -30.16065 33.76004  1.000 55.64181 ? 1468 HOH A O   1 
HETATM 5328 O O   . HOH EB 5 .   ? 1.81455   -28.36364 37.43116  1.000 46.35391 ? 1469 HOH A O   1 
HETATM 5329 O O   . HOH EB 5 .   ? -8.21109  -12.43470 56.52813  1.000 54.14785 ? 1470 HOH A O   1 
HETATM 5330 O O   . HOH EB 5 .   ? -26.27720 -10.38726 29.18827  1.000 55.74344 ? 1471 HOH A O   1 
HETATM 5331 O O   . HOH EB 5 .   ? 18.66335  -23.63602 42.65498  1.000 42.55831 ? 1472 HOH A O   1 
HETATM 5332 O O   . HOH EB 5 .   ? -12.86828 -16.61208 57.84637  1.000 55.22309 ? 1473 HOH A O   1 
HETATM 5333 O O   . HOH EB 5 .   ? -27.69965 15.64549  -1.34905  1.000 49.39276 ? 1474 HOH A O   1 
HETATM 5334 O O   . HOH EB 5 .   ? -34.09461 -15.07607 42.95569  1.000 50.05262 ? 1475 HOH A O   1 
HETATM 5335 O O   . HOH EB 5 .   ? -33.24279 -17.07654 44.86787  1.000 48.64947 ? 1476 HOH A O   1 
HETATM 5336 O O   . HOH EB 5 .   ? -33.67132 5.83265   15.79391  1.000 53.96136 ? 1477 HOH A O   1 
HETATM 5337 O O   . HOH EB 5 .   ? -6.94809  -44.78525 19.52215  1.000 58.11673 ? 1478 HOH A O   1 
HETATM 5338 O O   . HOH EB 5 .   ? -0.74183  -25.85834 33.76749  1.000 51.24364 ? 1479 HOH A O   1 
HETATM 5339 O O   . HOH EB 5 .   ? -10.73152 -42.24111 51.86298  1.000 56.06803 ? 1480 HOH A O   1 
HETATM 5340 O O   . HOH EB 5 .   ? 1.87908   5.41579   14.15530  1.000 47.47962 ? 1481 HOH A O   1 
HETATM 5341 O O   . HOH EB 5 .   ? -16.92391 -25.17563 55.71195  1.000 47.72410 ? 1482 HOH A O   1 
HETATM 5342 O O   . HOH EB 5 .   ? -3.84312  -40.85976 18.54642  1.000 59.54485 ? 1483 HOH A O   1 
HETATM 5343 O O   . HOH EB 5 .   ? -6.87816  -44.86182 33.19548  1.000 49.30510 ? 1484 HOH A O   1 
HETATM 5344 O O   . HOH EB 5 .   ? -26.87891 8.22903   18.27257  1.000 56.41057 ? 1485 HOH A O   1 
# 
