data_8YU8
# 
_entry.id   8YU8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8YU8         pdb_00008yu8 10.2210/pdb8yu8/pdb 
WWPDB D_1300046363 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8YU8 
_pdbx_database_status.recvd_initial_deposition_date   2024-03-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        . 
_pdbx_database_related.db_id          8YT6 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yo@phs.osaka-u.ac.jp 
_pdbx_contact_author.name_first         Takuya 
_pdbx_contact_author.name_last          Yoshida 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3491-9344 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tachibana, K.' 1  ? 
'Morie, T.'     2  ? 
'Fukuda, S.'    3  ? 
'Yuzuriha, T.'  4  ? 
'Ishimoto, K.'  5  ? 
'Nunomura, K.'  6  ? 
'Lin, B.'       7  ? 
'Miyachi, H.'   8  ? 
'Oki, H.'       9  ? 
'Kawahara, K.'  10 ? 
'Meguro, K.'    11 ? 
'Nakagawa, S.'  12 ? 
'Tsujikawa, K.' 13 ? 
'Akai, S.'      14 ? 
'Doi, T.'       15 ? 
'Yoshida, T.'   16 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural evolution of 1H-pyrazolo[3,4-b]pyridine-derived PPARalpha activators as leads for nonalcoholic steatohepatitis' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tachibana, K.' 1  ? 
primary 'Morie, T.'     2  ? 
primary 'Fukuda, S.'    3  ? 
primary 'Yuzuriha, T.'  4  ? 
primary 'Ishimoto, K.'  5  ? 
primary 'Nunomura, K.'  6  ? 
primary 'Lin, B.'       7  ? 
primary 'Miyachi, H.'   8  ? 
primary 'Oki, H.'       9  ? 
primary 'Kawahara, K.'  10 ? 
primary 'Meguro, K.'    11 ? 
primary 'Nakagawa, S.'  12 ? 
primary 'Tsujikawa, K.' 13 ? 
primary 'Akai, S.'      14 ? 
primary 'Doi, T.'       15 ? 
primary 'Yoshida, T.'   16 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peroxisome proliferator-activated receptor alpha'                                                              
30684.814 1   ? ? ? ? 
2 polymer     syn 'Peroxisome proliferator-activated receptor gamma coactivator 1-alpha'                                          
2405.782  1   ? ? ? ? 
3 non-polymer syn '6-(4-butoxycarbonylpiperazin-1-yl)-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' 
511.588   1   ? ? ? ? 
4 water       nat water                                                                                                           
18.015    102 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'PPAR-alpha,Nuclear receptor subfamily 1 group C member 1'                            
2 'PGC-1-alpha,PPAR-gamma coactivator 1-alpha,PPARGC-1-alpha,Ligand effect modulator 6' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
;GGQTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCC
QCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIME
PKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL
VTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
;
A ? 
2 'polypeptide(L)' no no PQEAEEPSLLKKLLLAPANTQL PQEAEEPSLLKKLLLAPANTQL B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '6-(4-butoxycarbonylpiperazin-1-yl)-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' A1LZ1 
4 water                                                                                                           HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   GLY n 
1 3   GLN n 
1 4   THR n 
1 5   ALA n 
1 6   ASP n 
1 7   LEU n 
1 8   LYS n 
1 9   SER n 
1 10  LEU n 
1 11  ALA n 
1 12  LYS n 
1 13  ARG n 
1 14  ILE n 
1 15  TYR n 
1 16  GLU n 
1 17  ALA n 
1 18  TYR n 
1 19  LEU n 
1 20  LYS n 
1 21  ASN n 
1 22  PHE n 
1 23  ASN n 
1 24  MET n 
1 25  ASN n 
1 26  LYS n 
1 27  VAL n 
1 28  LYS n 
1 29  ALA n 
1 30  ARG n 
1 31  VAL n 
1 32  ILE n 
1 33  LEU n 
1 34  SER n 
1 35  GLY n 
1 36  LYS n 
1 37  ALA n 
1 38  SER n 
1 39  ASN n 
1 40  ASN n 
1 41  PRO n 
1 42  PRO n 
1 43  PHE n 
1 44  VAL n 
1 45  ILE n 
1 46  HIS n 
1 47  ASP n 
1 48  MET n 
1 49  GLU n 
1 50  THR n 
1 51  LEU n 
1 52  CYS n 
1 53  MET n 
1 54  ALA n 
1 55  GLU n 
1 56  LYS n 
1 57  THR n 
1 58  LEU n 
1 59  VAL n 
1 60  ALA n 
1 61  LYS n 
1 62  LEU n 
1 63  VAL n 
1 64  ALA n 
1 65  ASN n 
1 66  GLY n 
1 67  ILE n 
1 68  GLN n 
1 69  ASN n 
1 70  LYS n 
1 71  GLU n 
1 72  ALA n 
1 73  GLU n 
1 74  VAL n 
1 75  ARG n 
1 76  ILE n 
1 77  PHE n 
1 78  HIS n 
1 79  CYS n 
1 80  CYS n 
1 81  GLN n 
1 82  CYS n 
1 83  THR n 
1 84  SER n 
1 85  VAL n 
1 86  GLU n 
1 87  THR n 
1 88  VAL n 
1 89  THR n 
1 90  GLU n 
1 91  LEU n 
1 92  THR n 
1 93  GLU n 
1 94  PHE n 
1 95  ALA n 
1 96  LYS n 
1 97  ALA n 
1 98  ILE n 
1 99  PRO n 
1 100 GLY n 
1 101 PHE n 
1 102 ALA n 
1 103 ASN n 
1 104 LEU n 
1 105 ASP n 
1 106 LEU n 
1 107 ASN n 
1 108 ASP n 
1 109 GLN n 
1 110 VAL n 
1 111 THR n 
1 112 LEU n 
1 113 LEU n 
1 114 LYS n 
1 115 TYR n 
1 116 GLY n 
1 117 VAL n 
1 118 TYR n 
1 119 GLU n 
1 120 ALA n 
1 121 ILE n 
1 122 PHE n 
1 123 ALA n 
1 124 MET n 
1 125 LEU n 
1 126 SER n 
1 127 SER n 
1 128 VAL n 
1 129 MET n 
1 130 ASN n 
1 131 LYS n 
1 132 ASP n 
1 133 GLY n 
1 134 MET n 
1 135 LEU n 
1 136 VAL n 
1 137 ALA n 
1 138 TYR n 
1 139 GLY n 
1 140 ASN n 
1 141 GLY n 
1 142 PHE n 
1 143 ILE n 
1 144 THR n 
1 145 ARG n 
1 146 GLU n 
1 147 PHE n 
1 148 LEU n 
1 149 LYS n 
1 150 SER n 
1 151 LEU n 
1 152 ARG n 
1 153 LYS n 
1 154 PRO n 
1 155 PHE n 
1 156 CYS n 
1 157 ASP n 
1 158 ILE n 
1 159 MET n 
1 160 GLU n 
1 161 PRO n 
1 162 LYS n 
1 163 PHE n 
1 164 ASP n 
1 165 PHE n 
1 166 ALA n 
1 167 MET n 
1 168 LYS n 
1 169 PHE n 
1 170 ASN n 
1 171 ALA n 
1 172 LEU n 
1 173 GLU n 
1 174 LEU n 
1 175 ASP n 
1 176 ASP n 
1 177 SER n 
1 178 ASP n 
1 179 ILE n 
1 180 SER n 
1 181 LEU n 
1 182 PHE n 
1 183 VAL n 
1 184 ALA n 
1 185 ALA n 
1 186 ILE n 
1 187 ILE n 
1 188 CYS n 
1 189 CYS n 
1 190 GLY n 
1 191 ASP n 
1 192 ARG n 
1 193 PRO n 
1 194 GLY n 
1 195 LEU n 
1 196 LEU n 
1 197 ASN n 
1 198 VAL n 
1 199 GLY n 
1 200 HIS n 
1 201 ILE n 
1 202 GLU n 
1 203 LYS n 
1 204 MET n 
1 205 GLN n 
1 206 GLU n 
1 207 GLY n 
1 208 ILE n 
1 209 VAL n 
1 210 HIS n 
1 211 VAL n 
1 212 LEU n 
1 213 ARG n 
1 214 LEU n 
1 215 HIS n 
1 216 LEU n 
1 217 GLN n 
1 218 SER n 
1 219 ASN n 
1 220 HIS n 
1 221 PRO n 
1 222 ASP n 
1 223 ASP n 
1 224 ILE n 
1 225 PHE n 
1 226 LEU n 
1 227 PHE n 
1 228 PRO n 
1 229 LYS n 
1 230 LEU n 
1 231 LEU n 
1 232 GLN n 
1 233 LYS n 
1 234 MET n 
1 235 ALA n 
1 236 ASP n 
1 237 LEU n 
1 238 ARG n 
1 239 GLN n 
1 240 LEU n 
1 241 VAL n 
1 242 THR n 
1 243 GLU n 
1 244 HIS n 
1 245 ALA n 
1 246 GLN n 
1 247 LEU n 
1 248 VAL n 
1 249 GLN n 
1 250 ILE n 
1 251 ILE n 
1 252 LYS n 
1 253 LYS n 
1 254 THR n 
1 255 GLU n 
1 256 SER n 
1 257 ASP n 
1 258 ALA n 
1 259 ALA n 
1 260 LEU n 
1 261 HIS n 
1 262 PRO n 
1 263 LEU n 
1 264 LEU n 
1 265 GLN n 
1 266 GLU n 
1 267 ILE n 
1 268 TYR n 
1 269 ARG n 
1 270 ASP n 
1 271 MET n 
1 272 TYR n 
2 1   PRO n 
2 2   GLN n 
2 3   GLU n 
2 4   ALA n 
2 5   GLU n 
2 6   GLU n 
2 7   PRO n 
2 8   SER n 
2 9   LEU n 
2 10  LEU n 
2 11  LYS n 
2 12  LYS n 
2 13  LEU n 
2 14  LEU n 
2 15  LEU n 
2 16  ALA n 
2 17  PRO n 
2 18  ALA n 
2 19  ASN n 
2 20  THR n 
2 21  GLN n 
2 22  LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   272 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'PPARA, NR1C1, PPAR' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       22 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1LZ1 non-polymer         . 
'6-(4-butoxycarbonylpiperazin-1-yl)-1-(4-fluorophenyl)-3-pentan-3-yl-pyrazolo[3,4-b]pyridine-4-carboxylic acid' ? 
'C27 H34 F N5 O4' 511.588 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'    121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ? 'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'     131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'      105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'      119.119 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   197 ?   ?   ?   A . n 
A 1 2   GLY 2   198 ?   ?   ?   A . n 
A 1 3   GLN 3   199 ?   ?   ?   A . n 
A 1 4   THR 4   200 ?   ?   ?   A . n 
A 1 5   ALA 5   201 ?   ?   ?   A . n 
A 1 6   ASP 6   202 ?   ?   ?   A . n 
A 1 7   LEU 7   203 ?   ?   ?   A . n 
A 1 8   LYS 8   204 204 LYS LYS A . n 
A 1 9   SER 9   205 205 SER SER A . n 
A 1 10  LEU 10  206 206 LEU LEU A . n 
A 1 11  ALA 11  207 207 ALA ALA A . n 
A 1 12  LYS 12  208 208 LYS LYS A . n 
A 1 13  ARG 13  209 209 ARG ARG A . n 
A 1 14  ILE 14  210 210 ILE ILE A . n 
A 1 15  TYR 15  211 211 TYR TYR A . n 
A 1 16  GLU 16  212 212 GLU GLU A . n 
A 1 17  ALA 17  213 213 ALA ALA A . n 
A 1 18  TYR 18  214 214 TYR TYR A . n 
A 1 19  LEU 19  215 215 LEU LEU A . n 
A 1 20  LYS 20  216 216 LYS LYS A . n 
A 1 21  ASN 21  217 217 ASN ASN A . n 
A 1 22  PHE 22  218 218 PHE PHE A . n 
A 1 23  ASN 23  219 219 ASN ASN A . n 
A 1 24  MET 24  220 220 MET MET A . n 
A 1 25  ASN 25  221 221 ASN ASN A . n 
A 1 26  LYS 26  222 222 LYS LYS A . n 
A 1 27  VAL 27  223 223 VAL VAL A . n 
A 1 28  LYS 28  224 224 LYS LYS A . n 
A 1 29  ALA 29  225 225 ALA ALA A . n 
A 1 30  ARG 30  226 226 ARG ARG A . n 
A 1 31  VAL 31  227 227 VAL VAL A . n 
A 1 32  ILE 32  228 228 ILE ILE A . n 
A 1 33  LEU 33  229 229 LEU LEU A . n 
A 1 34  SER 34  230 230 SER SER A . n 
A 1 35  GLY 35  231 231 GLY GLY A . n 
A 1 36  LYS 36  232 232 LYS LYS A . n 
A 1 37  ALA 37  233 233 ALA ALA A . n 
A 1 38  SER 38  234 234 SER SER A . n 
A 1 39  ASN 39  235 235 ASN ASN A . n 
A 1 40  ASN 40  236 236 ASN ASN A . n 
A 1 41  PRO 41  237 237 PRO PRO A . n 
A 1 42  PRO 42  238 238 PRO PRO A . n 
A 1 43  PHE 43  239 239 PHE PHE A . n 
A 1 44  VAL 44  240 240 VAL VAL A . n 
A 1 45  ILE 45  241 241 ILE ILE A . n 
A 1 46  HIS 46  242 242 HIS HIS A . n 
A 1 47  ASP 47  243 243 ASP ASP A . n 
A 1 48  MET 48  244 244 MET MET A . n 
A 1 49  GLU 49  245 245 GLU GLU A . n 
A 1 50  THR 50  246 246 THR THR A . n 
A 1 51  LEU 51  247 247 LEU LEU A . n 
A 1 52  CYS 52  248 248 CYS CYS A . n 
A 1 53  MET 53  249 249 MET MET A . n 
A 1 54  ALA 54  250 250 ALA ALA A . n 
A 1 55  GLU 55  251 251 GLU GLU A . n 
A 1 56  LYS 56  252 252 LYS LYS A . n 
A 1 57  THR 57  253 253 THR THR A . n 
A 1 58  LEU 58  254 254 LEU LEU A . n 
A 1 59  VAL 59  255 255 VAL VAL A . n 
A 1 60  ALA 60  256 256 ALA ALA A . n 
A 1 61  LYS 61  257 257 LYS LYS A . n 
A 1 62  LEU 62  258 258 LEU LEU A . n 
A 1 63  VAL 63  259 259 VAL VAL A . n 
A 1 64  ALA 64  260 260 ALA ALA A . n 
A 1 65  ASN 65  261 261 ASN ASN A . n 
A 1 66  GLY 66  262 262 GLY GLY A . n 
A 1 67  ILE 67  263 263 ILE ILE A . n 
A 1 68  GLN 68  264 264 GLN GLN A . n 
A 1 69  ASN 69  265 265 ASN ASN A . n 
A 1 70  LYS 70  266 266 LYS LYS A . n 
A 1 71  GLU 71  267 267 GLU GLU A . n 
A 1 72  ALA 72  268 268 ALA ALA A . n 
A 1 73  GLU 73  269 269 GLU GLU A . n 
A 1 74  VAL 74  270 270 VAL VAL A . n 
A 1 75  ARG 75  271 271 ARG ARG A . n 
A 1 76  ILE 76  272 272 ILE ILE A . n 
A 1 77  PHE 77  273 273 PHE PHE A . n 
A 1 78  HIS 78  274 274 HIS HIS A . n 
A 1 79  CYS 79  275 275 CYS CYS A . n 
A 1 80  CYS 80  276 276 CYS CYS A . n 
A 1 81  GLN 81  277 277 GLN GLN A . n 
A 1 82  CYS 82  278 278 CYS CYS A . n 
A 1 83  THR 83  279 279 THR THR A . n 
A 1 84  SER 84  280 280 SER SER A . n 
A 1 85  VAL 85  281 281 VAL VAL A . n 
A 1 86  GLU 86  282 282 GLU GLU A . n 
A 1 87  THR 87  283 283 THR THR A . n 
A 1 88  VAL 88  284 284 VAL VAL A . n 
A 1 89  THR 89  285 285 THR THR A . n 
A 1 90  GLU 90  286 286 GLU GLU A . n 
A 1 91  LEU 91  287 287 LEU LEU A . n 
A 1 92  THR 92  288 288 THR THR A . n 
A 1 93  GLU 93  289 289 GLU GLU A . n 
A 1 94  PHE 94  290 290 PHE PHE A . n 
A 1 95  ALA 95  291 291 ALA ALA A . n 
A 1 96  LYS 96  292 292 LYS LYS A . n 
A 1 97  ALA 97  293 293 ALA ALA A . n 
A 1 98  ILE 98  294 294 ILE ILE A . n 
A 1 99  PRO 99  295 295 PRO PRO A . n 
A 1 100 GLY 100 296 296 GLY GLY A . n 
A 1 101 PHE 101 297 297 PHE PHE A . n 
A 1 102 ALA 102 298 298 ALA ALA A . n 
A 1 103 ASN 103 299 299 ASN ASN A . n 
A 1 104 LEU 104 300 300 LEU LEU A . n 
A 1 105 ASP 105 301 301 ASP ASP A . n 
A 1 106 LEU 106 302 302 LEU LEU A . n 
A 1 107 ASN 107 303 303 ASN ASN A . n 
A 1 108 ASP 108 304 304 ASP ASP A . n 
A 1 109 GLN 109 305 305 GLN GLN A . n 
A 1 110 VAL 110 306 306 VAL VAL A . n 
A 1 111 THR 111 307 307 THR THR A . n 
A 1 112 LEU 112 308 308 LEU LEU A . n 
A 1 113 LEU 113 309 309 LEU LEU A . n 
A 1 114 LYS 114 310 310 LYS LYS A . n 
A 1 115 TYR 115 311 311 TYR TYR A . n 
A 1 116 GLY 116 312 312 GLY GLY A . n 
A 1 117 VAL 117 313 313 VAL VAL A . n 
A 1 118 TYR 118 314 314 TYR TYR A . n 
A 1 119 GLU 119 315 315 GLU GLU A . n 
A 1 120 ALA 120 316 316 ALA ALA A . n 
A 1 121 ILE 121 317 317 ILE ILE A . n 
A 1 122 PHE 122 318 318 PHE PHE A . n 
A 1 123 ALA 123 319 319 ALA ALA A . n 
A 1 124 MET 124 320 320 MET MET A . n 
A 1 125 LEU 125 321 321 LEU LEU A . n 
A 1 126 SER 126 322 322 SER SER A . n 
A 1 127 SER 127 323 323 SER SER A . n 
A 1 128 VAL 128 324 324 VAL VAL A . n 
A 1 129 MET 129 325 325 MET MET A . n 
A 1 130 ASN 130 326 326 ASN ASN A . n 
A 1 131 LYS 131 327 327 LYS LYS A . n 
A 1 132 ASP 132 328 328 ASP ASP A . n 
A 1 133 GLY 133 329 329 GLY GLY A . n 
A 1 134 MET 134 330 330 MET MET A . n 
A 1 135 LEU 135 331 331 LEU LEU A . n 
A 1 136 VAL 136 332 332 VAL VAL A . n 
A 1 137 ALA 137 333 333 ALA ALA A . n 
A 1 138 TYR 138 334 334 TYR TYR A . n 
A 1 139 GLY 139 335 335 GLY GLY A . n 
A 1 140 ASN 140 336 336 ASN ASN A . n 
A 1 141 GLY 141 337 337 GLY GLY A . n 
A 1 142 PHE 142 338 338 PHE PHE A . n 
A 1 143 ILE 143 339 339 ILE ILE A . n 
A 1 144 THR 144 340 340 THR THR A . n 
A 1 145 ARG 145 341 341 ARG ARG A . n 
A 1 146 GLU 146 342 342 GLU GLU A . n 
A 1 147 PHE 147 343 343 PHE PHE A . n 
A 1 148 LEU 148 344 344 LEU LEU A . n 
A 1 149 LYS 149 345 345 LYS LYS A . n 
A 1 150 SER 150 346 346 SER SER A . n 
A 1 151 LEU 151 347 347 LEU LEU A . n 
A 1 152 ARG 152 348 348 ARG ARG A . n 
A 1 153 LYS 153 349 349 LYS LYS A . n 
A 1 154 PRO 154 350 350 PRO PRO A . n 
A 1 155 PHE 155 351 351 PHE PHE A . n 
A 1 156 CYS 156 352 352 CYS CYS A . n 
A 1 157 ASP 157 353 353 ASP ASP A . n 
A 1 158 ILE 158 354 354 ILE ILE A . n 
A 1 159 MET 159 355 355 MET MET A . n 
A 1 160 GLU 160 356 356 GLU GLU A . n 
A 1 161 PRO 161 357 357 PRO PRO A . n 
A 1 162 LYS 162 358 358 LYS LYS A . n 
A 1 163 PHE 163 359 359 PHE PHE A . n 
A 1 164 ASP 164 360 360 ASP ASP A . n 
A 1 165 PHE 165 361 361 PHE PHE A . n 
A 1 166 ALA 166 362 362 ALA ALA A . n 
A 1 167 MET 167 363 363 MET MET A . n 
A 1 168 LYS 168 364 364 LYS LYS A . n 
A 1 169 PHE 169 365 365 PHE PHE A . n 
A 1 170 ASN 170 366 366 ASN ASN A . n 
A 1 171 ALA 171 367 367 ALA ALA A . n 
A 1 172 LEU 172 368 368 LEU LEU A . n 
A 1 173 GLU 173 369 369 GLU GLU A . n 
A 1 174 LEU 174 370 370 LEU LEU A . n 
A 1 175 ASP 175 371 371 ASP ASP A . n 
A 1 176 ASP 176 372 372 ASP ASP A . n 
A 1 177 SER 177 373 373 SER SER A . n 
A 1 178 ASP 178 374 374 ASP ASP A . n 
A 1 179 ILE 179 375 375 ILE ILE A . n 
A 1 180 SER 180 376 376 SER SER A . n 
A 1 181 LEU 181 377 377 LEU LEU A . n 
A 1 182 PHE 182 378 378 PHE PHE A . n 
A 1 183 VAL 183 379 379 VAL VAL A . n 
A 1 184 ALA 184 380 380 ALA ALA A . n 
A 1 185 ALA 185 381 381 ALA ALA A . n 
A 1 186 ILE 186 382 382 ILE ILE A . n 
A 1 187 ILE 187 383 383 ILE ILE A . n 
A 1 188 CYS 188 384 384 CYS CYS A . n 
A 1 189 CYS 189 385 385 CYS CYS A . n 
A 1 190 GLY 190 386 386 GLY GLY A . n 
A 1 191 ASP 191 387 387 ASP ASP A . n 
A 1 192 ARG 192 388 388 ARG ARG A . n 
A 1 193 PRO 193 389 389 PRO PRO A . n 
A 1 194 GLY 194 390 390 GLY GLY A . n 
A 1 195 LEU 195 391 391 LEU LEU A . n 
A 1 196 LEU 196 392 392 LEU LEU A . n 
A 1 197 ASN 197 393 393 ASN ASN A . n 
A 1 198 VAL 198 394 394 VAL VAL A . n 
A 1 199 GLY 199 395 395 GLY GLY A . n 
A 1 200 HIS 200 396 396 HIS HIS A . n 
A 1 201 ILE 201 397 397 ILE ILE A . n 
A 1 202 GLU 202 398 398 GLU GLU A . n 
A 1 203 LYS 203 399 399 LYS LYS A . n 
A 1 204 MET 204 400 400 MET MET A . n 
A 1 205 GLN 205 401 401 GLN GLN A . n 
A 1 206 GLU 206 402 402 GLU GLU A . n 
A 1 207 GLY 207 403 403 GLY GLY A . n 
A 1 208 ILE 208 404 404 ILE ILE A . n 
A 1 209 VAL 209 405 405 VAL VAL A . n 
A 1 210 HIS 210 406 406 HIS HIS A . n 
A 1 211 VAL 211 407 407 VAL VAL A . n 
A 1 212 LEU 212 408 408 LEU LEU A . n 
A 1 213 ARG 213 409 409 ARG ARG A . n 
A 1 214 LEU 214 410 410 LEU LEU A . n 
A 1 215 HIS 215 411 411 HIS HIS A . n 
A 1 216 LEU 216 412 412 LEU LEU A . n 
A 1 217 GLN 217 413 413 GLN GLN A . n 
A 1 218 SER 218 414 414 SER SER A . n 
A 1 219 ASN 219 415 415 ASN ASN A . n 
A 1 220 HIS 220 416 416 HIS HIS A . n 
A 1 221 PRO 221 417 417 PRO PRO A . n 
A 1 222 ASP 222 418 418 ASP ASP A . n 
A 1 223 ASP 223 419 419 ASP ASP A . n 
A 1 224 ILE 224 420 420 ILE ILE A . n 
A 1 225 PHE 225 421 421 PHE PHE A . n 
A 1 226 LEU 226 422 422 LEU LEU A . n 
A 1 227 PHE 227 423 423 PHE PHE A . n 
A 1 228 PRO 228 424 424 PRO PRO A . n 
A 1 229 LYS 229 425 425 LYS LYS A . n 
A 1 230 LEU 230 426 426 LEU LEU A . n 
A 1 231 LEU 231 427 427 LEU LEU A . n 
A 1 232 GLN 232 428 428 GLN GLN A . n 
A 1 233 LYS 233 429 429 LYS LYS A . n 
A 1 234 MET 234 430 430 MET MET A . n 
A 1 235 ALA 235 431 431 ALA ALA A . n 
A 1 236 ASP 236 432 432 ASP ASP A . n 
A 1 237 LEU 237 433 433 LEU LEU A . n 
A 1 238 ARG 238 434 434 ARG ARG A . n 
A 1 239 GLN 239 435 435 GLN GLN A . n 
A 1 240 LEU 240 436 436 LEU LEU A . n 
A 1 241 VAL 241 437 437 VAL VAL A . n 
A 1 242 THR 242 438 438 THR THR A . n 
A 1 243 GLU 243 439 439 GLU GLU A . n 
A 1 244 HIS 244 440 440 HIS HIS A . n 
A 1 245 ALA 245 441 441 ALA ALA A . n 
A 1 246 GLN 246 442 442 GLN GLN A . n 
A 1 247 LEU 247 443 443 LEU LEU A . n 
A 1 248 VAL 248 444 444 VAL VAL A . n 
A 1 249 GLN 249 445 445 GLN GLN A . n 
A 1 250 ILE 250 446 446 ILE ILE A . n 
A 1 251 ILE 251 447 447 ILE ILE A . n 
A 1 252 LYS 252 448 448 LYS LYS A . n 
A 1 253 LYS 253 449 449 LYS LYS A . n 
A 1 254 THR 254 450 450 THR THR A . n 
A 1 255 GLU 255 451 451 GLU GLU A . n 
A 1 256 SER 256 452 452 SER SER A . n 
A 1 257 ASP 257 453 453 ASP ASP A . n 
A 1 258 ALA 258 454 454 ALA ALA A . n 
A 1 259 ALA 259 455 455 ALA ALA A . n 
A 1 260 LEU 260 456 456 LEU LEU A . n 
A 1 261 HIS 261 457 457 HIS HIS A . n 
A 1 262 PRO 262 458 458 PRO PRO A . n 
A 1 263 LEU 263 459 459 LEU LEU A . n 
A 1 264 LEU 264 460 460 LEU LEU A . n 
A 1 265 GLN 265 461 461 GLN GLN A . n 
A 1 266 GLU 266 462 462 GLU GLU A . n 
A 1 267 ILE 267 463 463 ILE ILE A . n 
A 1 268 TYR 268 464 464 TYR TYR A . n 
A 1 269 ARG 269 465 465 ARG ARG A . n 
A 1 270 ASP 270 466 466 ASP ASP A . n 
A 1 271 MET 271 467 467 MET MET A . n 
A 1 272 TYR 272 468 ?   ?   ?   A . n 
B 2 1   PRO 1   135 ?   ?   ?   B . n 
B 2 2   GLN 2   136 ?   ?   ?   B . n 
B 2 3   GLU 3   137 ?   ?   ?   B . n 
B 2 4   ALA 4   138 ?   ?   ?   B . n 
B 2 5   GLU 5   139 ?   ?   ?   B . n 
B 2 6   GLU 6   140 ?   ?   ?   B . n 
B 2 7   PRO 7   141 141 PRO PRO B . n 
B 2 8   SER 8   142 142 SER SER B . n 
B 2 9   LEU 9   143 143 LEU LEU B . n 
B 2 10  LEU 10  144 144 LEU LEU B . n 
B 2 11  LYS 11  145 145 LYS LYS B . n 
B 2 12  LYS 12  146 146 LYS LYS B . n 
B 2 13  LEU 13  147 147 LEU LEU B . n 
B 2 14  LEU 14  148 148 LEU LEU B . n 
B 2 15  LEU 15  149 149 LEU LEU B . n 
B 2 16  ALA 16  150 150 ALA ALA B . n 
B 2 17  PRO 17  151 151 PRO PRO B . n 
B 2 18  ALA 18  152 ?   ?   ?   B . n 
B 2 19  ASN 19  153 ?   ?   ?   B . n 
B 2 20  THR 20  154 ?   ?   ?   B . n 
B 2 21  GLN 21  155 ?   ?   ?   B . n 
B 2 22  LEU 22  156 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1LZ1 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1LZ1 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1LZ1 1   500 500 A1LZ1 A08 A . 
D 4 HOH   1   601 99  HOH   HOH A . 
D 4 HOH   2   602 90  HOH   HOH A . 
D 4 HOH   3   603 102 HOH   HOH A . 
D 4 HOH   4   604 88  HOH   HOH A . 
D 4 HOH   5   605 71  HOH   HOH A . 
D 4 HOH   6   606 33  HOH   HOH A . 
D 4 HOH   7   607 55  HOH   HOH A . 
D 4 HOH   8   608 37  HOH   HOH A . 
D 4 HOH   9   609 51  HOH   HOH A . 
D 4 HOH   10  610 63  HOH   HOH A . 
D 4 HOH   11  611 9   HOH   HOH A . 
D 4 HOH   12  612 65  HOH   HOH A . 
D 4 HOH   13  613 25  HOH   HOH A . 
D 4 HOH   14  614 57  HOH   HOH A . 
D 4 HOH   15  615 23  HOH   HOH A . 
D 4 HOH   16  616 53  HOH   HOH A . 
D 4 HOH   17  617 72  HOH   HOH A . 
D 4 HOH   18  618 75  HOH   HOH A . 
D 4 HOH   19  619 54  HOH   HOH A . 
D 4 HOH   20  620 6   HOH   HOH A . 
D 4 HOH   21  621 87  HOH   HOH A . 
D 4 HOH   22  622 13  HOH   HOH A . 
D 4 HOH   23  623 42  HOH   HOH A . 
D 4 HOH   24  624 10  HOH   HOH A . 
D 4 HOH   25  625 69  HOH   HOH A . 
D 4 HOH   26  626 39  HOH   HOH A . 
D 4 HOH   27  627 91  HOH   HOH A . 
D 4 HOH   28  628 1   HOH   HOH A . 
D 4 HOH   29  629 62  HOH   HOH A . 
D 4 HOH   30  630 35  HOH   HOH A . 
D 4 HOH   31  631 19  HOH   HOH A . 
D 4 HOH   32  632 83  HOH   HOH A . 
D 4 HOH   33  633 46  HOH   HOH A . 
D 4 HOH   34  634 60  HOH   HOH A . 
D 4 HOH   35  635 31  HOH   HOH A . 
D 4 HOH   36  636 5   HOH   HOH A . 
D 4 HOH   37  637 47  HOH   HOH A . 
D 4 HOH   38  638 41  HOH   HOH A . 
D 4 HOH   39  639 67  HOH   HOH A . 
D 4 HOH   40  640 43  HOH   HOH A . 
D 4 HOH   41  641 21  HOH   HOH A . 
D 4 HOH   42  642 11  HOH   HOH A . 
D 4 HOH   43  643 74  HOH   HOH A . 
D 4 HOH   44  644 7   HOH   HOH A . 
D 4 HOH   45  645 80  HOH   HOH A . 
D 4 HOH   46  646 38  HOH   HOH A . 
D 4 HOH   47  647 85  HOH   HOH A . 
D 4 HOH   48  648 40  HOH   HOH A . 
D 4 HOH   49  649 49  HOH   HOH A . 
D 4 HOH   50  650 12  HOH   HOH A . 
D 4 HOH   51  651 66  HOH   HOH A . 
D 4 HOH   52  652 4   HOH   HOH A . 
D 4 HOH   53  653 14  HOH   HOH A . 
D 4 HOH   54  654 17  HOH   HOH A . 
D 4 HOH   55  655 29  HOH   HOH A . 
D 4 HOH   56  656 18  HOH   HOH A . 
D 4 HOH   57  657 2   HOH   HOH A . 
D 4 HOH   58  658 20  HOH   HOH A . 
D 4 HOH   59  659 52  HOH   HOH A . 
D 4 HOH   60  660 30  HOH   HOH A . 
D 4 HOH   61  661 56  HOH   HOH A . 
D 4 HOH   62  662 24  HOH   HOH A . 
D 4 HOH   63  663 16  HOH   HOH A . 
D 4 HOH   64  664 8   HOH   HOH A . 
D 4 HOH   65  665 93  HOH   HOH A . 
D 4 HOH   66  666 70  HOH   HOH A . 
D 4 HOH   67  667 58  HOH   HOH A . 
D 4 HOH   68  668 22  HOH   HOH A . 
D 4 HOH   69  669 3   HOH   HOH A . 
D 4 HOH   70  670 86  HOH   HOH A . 
D 4 HOH   71  671 34  HOH   HOH A . 
D 4 HOH   72  672 101 HOH   HOH A . 
D 4 HOH   73  673 68  HOH   HOH A . 
D 4 HOH   74  674 61  HOH   HOH A . 
D 4 HOH   75  675 82  HOH   HOH A . 
D 4 HOH   76  676 89  HOH   HOH A . 
D 4 HOH   77  677 73  HOH   HOH A . 
D 4 HOH   78  678 78  HOH   HOH A . 
D 4 HOH   79  679 36  HOH   HOH A . 
D 4 HOH   80  680 28  HOH   HOH A . 
D 4 HOH   81  681 27  HOH   HOH A . 
D 4 HOH   82  682 48  HOH   HOH A . 
D 4 HOH   83  683 98  HOH   HOH A . 
D 4 HOH   84  684 50  HOH   HOH A . 
D 4 HOH   85  685 76  HOH   HOH A . 
D 4 HOH   86  686 92  HOH   HOH A . 
D 4 HOH   87  687 15  HOH   HOH A . 
D 4 HOH   88  688 81  HOH   HOH A . 
D 4 HOH   89  689 26  HOH   HOH A . 
D 4 HOH   90  690 44  HOH   HOH A . 
D 4 HOH   91  691 97  HOH   HOH A . 
D 4 HOH   92  692 100 HOH   HOH A . 
D 4 HOH   93  693 77  HOH   HOH A . 
D 4 HOH   94  694 32  HOH   HOH A . 
D 4 HOH   95  695 95  HOH   HOH A . 
D 4 HOH   96  696 64  HOH   HOH A . 
D 4 HOH   97  697 59  HOH   HOH A . 
D 4 HOH   98  698 96  HOH   HOH A . 
D 4 HOH   99  699 79  HOH   HOH A . 
D 4 HOH   100 700 84  HOH   HOH A . 
D 4 HOH   101 701 94  HOH   HOH A . 
E 4 HOH   1   201 45  HOH   HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8YU8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     49.838 
_cell.length_a_esd                 ? 
_cell.length_b                     61.593 
_cell.length_b_esd                 ? 
_cell.length_c                     97.750 
_cell.length_c_esd                 ? 
_cell.volume                       300060.432 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8YU8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8YU8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.27 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.74 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES-NaOH, 19-23% PEG 4000, 19-23% 1,2-propanediol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-07-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SPRING-8 BEAMLINE BL26B1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL26B1 
_diffrn_source.pdbx_synchrotron_site       SPring-8 
# 
_reflns.B_iso_Wilson_estimate                          43.87 
_reflns.entry_id                                       8YU8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.95 
_reflns.d_resolution_low                               48.88 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     22659 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.081 
_reflns.pdbx_Rpim_I_all                                0.026 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       229437 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.077 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.95 
_reflns_shell.d_res_low                                     2.00 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           17270 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1589 
_reflns_shell.percent_possible_obs                          100.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               10.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.1 
_reflns_shell.pdbx_Rrim_I_all                               2.393 
_reflns_shell.pdbx_Rpim_I_all                               0.721 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.579 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.280 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               49.52 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8YU8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.95 
_refine.ls_d_res_low                             38.74 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22599 
_refine.ls_number_reflns_R_free                  2292 
_refine.ls_number_reflns_R_work                  20307 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.95 
_refine.ls_percent_reflns_R_free                 10.14 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2225 
_refine.ls_R_factor_R_free                       0.2594 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2183 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 29.3874 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3469 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.95 
_refine_hist.d_res_low                        38.74 
_refine_hist.number_atoms_solvent             102 
_refine_hist.number_atoms_total               2311 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2172 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         37 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0059  ? 2250 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8028  ? 3034 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0527  ? 347  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0051  ? 381  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 27.1865 ? 853  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.95 1.99  . . 162 1258 99.93  . . . . 0.4296 . . . . . . . . . . . 0.5030 
'X-RAY DIFFRACTION' 1.99 2.04  . . 137 1218 99.93  . . . . 0.3696 . . . . . . . . . . . 0.4171 
'X-RAY DIFFRACTION' 2.04 2.09  . . 148 1247 100.00 . . . . 0.2882 . . . . . . . . . . . 0.3470 
'X-RAY DIFFRACTION' 2.09 2.15  . . 147 1242 100.00 . . . . 0.2788 . . . . . . . . . . . 0.3184 
'X-RAY DIFFRACTION' 2.15 2.21  . . 125 1265 100.00 . . . . 0.2554 . . . . . . . . . . . 0.2969 
'X-RAY DIFFRACTION' 2.21 2.28  . . 148 1251 99.86  . . . . 0.2497 . . . . . . . . . . . 0.2855 
'X-RAY DIFFRACTION' 2.28 2.36  . . 131 1253 99.93  . . . . 0.2406 . . . . . . . . . . . 0.2920 
'X-RAY DIFFRACTION' 2.36 2.46  . . 135 1259 100.00 . . . . 0.2407 . . . . . . . . . . . 0.2989 
'X-RAY DIFFRACTION' 2.46 2.57  . . 148 1252 99.93  . . . . 0.2391 . . . . . . . . . . . 0.2697 
'X-RAY DIFFRACTION' 2.57 2.70  . . 132 1265 99.93  . . . . 0.2364 . . . . . . . . . . . 0.2774 
'X-RAY DIFFRACTION' 2.70 2.87  . . 144 1253 99.93  . . . . 0.2432 . . . . . . . . . . . 0.3052 
'X-RAY DIFFRACTION' 2.87 3.10  . . 142 1290 99.93  . . . . 0.2462 . . . . . . . . . . . 0.2810 
'X-RAY DIFFRACTION' 3.10 3.41  . . 130 1292 100.00 . . . . 0.2311 . . . . . . . . . . . 0.2567 
'X-RAY DIFFRACTION' 3.41 3.90  . . 141 1293 100.00 . . . . 0.1966 . . . . . . . . . . . 0.2212 
'X-RAY DIFFRACTION' 3.90 4.91  . . 158 1293 99.86  . . . . 0.1790 . . . . . . . . . . . 0.2312 
'X-RAY DIFFRACTION' 4.91 38.74 . . 164 1376 99.94  . . . . 0.1945 . . . . . . . . . . . 0.2375 
# 
_struct.entry_id                     8YU8 
_struct.title                        
'Human PPAR alpha ligand binding domain in complex with a 1H-pyrazolo[3,4-b]pyridine-derived compound' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8YU8 
_struct_keywords.text            'Agonist, Complex, Nuclear receptor, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PPARA_HUMAN Q07869 ? 1 
;TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCT
SVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF
DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE
HAQLVQIIKKTESDAALHPLLQEIYRDMY
;
200 
2 UNP PRGC1_HUMAN Q9UBK2 ? 2 PQEAEEPSLLKKLLLAPANTQL 135 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8YU8 A 4 ? 272 ? Q07869 200 ? 468 ? 200 468 
2 2 8YU8 B 1 ? 22  ? Q9UBK2 135 ? 156 ? 135 156 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8YU8 GLY A 1 ? UNP Q07869 ? ? 'expression tag' 197 1 
1 8YU8 GLY A 2 ? UNP Q07869 ? ? 'expression tag' 198 2 
1 8YU8 GLN A 3 ? UNP Q07869 ? ? 'expression tag' 199 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1070  ? 
1 MORE         -9    ? 
1 'SSA (A^2)'  13090 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 9   ? PHE A 22  ? SER A 205 PHE A 218 1 ? 14 
HELX_P HELX_P2  AA2 ASN A 25  ? GLY A 35  ? ASN A 221 GLY A 231 1 ? 11 
HELX_P HELX_P3  AA3 ASP A 47  ? VAL A 59  ? ASP A 243 VAL A 255 1 ? 13 
HELX_P HELX_P4  AA4 VAL A 59  ? ASN A 65  ? VAL A 255 ASN A 261 1 ? 7  
HELX_P HELX_P5  AA5 GLY A 66  ? LYS A 70  ? GLY A 262 LYS A 266 5 ? 5  
HELX_P HELX_P6  AA6 GLU A 71  ? ALA A 97  ? GLU A 267 ALA A 293 1 ? 27 
HELX_P HELX_P7  AA7 GLY A 100 ? LEU A 104 ? GLY A 296 LEU A 300 5 ? 5  
HELX_P HELX_P8  AA8 ASP A 105 ? SER A 126 ? ASP A 301 SER A 322 1 ? 22 
HELX_P HELX_P9  AA9 ARG A 145 ? SER A 150 ? ARG A 341 SER A 346 1 ? 6  
HELX_P HELX_P10 AB1 PRO A 154 ? ILE A 158 ? PRO A 350 ILE A 354 5 ? 5  
HELX_P HELX_P11 AB2 MET A 159 ? LEU A 172 ? MET A 355 LEU A 368 1 ? 14 
HELX_P HELX_P12 AB3 ASP A 175 ? CYS A 188 ? ASP A 371 CYS A 384 1 ? 14 
HELX_P HELX_P13 AB4 ASN A 197 ? HIS A 220 ? ASN A 393 HIS A 416 1 ? 24 
HELX_P HELX_P14 AB5 PHE A 225 ? GLU A 255 ? PHE A 421 GLU A 451 1 ? 31 
HELX_P HELX_P15 AB6 HIS A 261 ? ARG A 269 ? HIS A 457 ARG A 465 1 ? 9  
HELX_P HELX_P16 AB7 SER B 8   ? ALA B 16  ? SER B 142 ALA B 150 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LYS 
_struct_mon_prot_cis.label_seq_id           153 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LYS 
_struct_mon_prot_cis.auth_seq_id            349 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    154 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     350 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -2.34 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   4 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 43  ? ILE A 45  ? PHE A 239 ILE A 241 
AA1 2 GLY A 141 ? THR A 144 ? GLY A 337 THR A 340 
AA1 3 GLY A 133 ? VAL A 136 ? GLY A 329 VAL A 332 
AA1 4 MET A 129 ? ASN A 130 ? MET A 325 ASN A 326 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 45  ? N ILE A 241 O PHE A 142 ? O PHE A 338 
AA1 2 3 O GLY A 141 ? O GLY A 337 N VAL A 136 ? N VAL A 332 
AA1 3 4 O GLY A 133 ? O GLY A 329 N ASN A 130 ? N ASN A 326 
# 
_pdbx_entry_details.entry_id                   8YU8 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 236 ? ? -112.75 77.56 
2 1 ASP A 453 ? ? -91.75  42.08 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 197 ? A GLY 1   
2  1 Y 1 A GLY 198 ? A GLY 2   
3  1 Y 1 A GLN 199 ? A GLN 3   
4  1 Y 1 A THR 200 ? A THR 4   
5  1 Y 1 A ALA 201 ? A ALA 5   
6  1 Y 1 A ASP 202 ? A ASP 6   
7  1 Y 1 A LEU 203 ? A LEU 7   
8  1 Y 1 A TYR 468 ? A TYR 272 
9  1 Y 1 B PRO 135 ? B PRO 1   
10 1 Y 1 B GLN 136 ? B GLN 2   
11 1 Y 1 B GLU 137 ? B GLU 3   
12 1 Y 1 B ALA 138 ? B ALA 4   
13 1 Y 1 B GLU 139 ? B GLU 5   
14 1 Y 1 B GLU 140 ? B GLU 6   
15 1 Y 1 B ALA 152 ? B ALA 18  
16 1 Y 1 B ASN 153 ? B ASN 19  
17 1 Y 1 B THR 154 ? B THR 20  
18 1 Y 1 B GLN 155 ? B GLN 21  
19 1 Y 1 B LEU 156 ? B LEU 22  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1LZ1 C10  C N N 1   
A1LZ1 C11  C N N 2   
A1LZ1 C12  C N N 3   
A1LZ1 C16  C Y N 4   
A1LZ1 C01  C Y N 5   
A1LZ1 C02  C Y N 6   
A1LZ1 C03  C Y N 7   
A1LZ1 C04  C Y N 8   
A1LZ1 C05  C Y N 9   
A1LZ1 C06  C Y N 10  
A1LZ1 C08  C N N 11  
A1LZ1 C09  C N N 12  
A1LZ1 C13  C N N 13  
A1LZ1 C14  C Y N 14  
A1LZ1 C15  C Y N 15  
A1LZ1 C17  C Y N 16  
A1LZ1 C18  C Y N 17  
A1LZ1 C19  C Y N 18  
A1LZ1 C26  C N N 19  
A1LZ1 C27  C N N 20  
A1LZ1 C28  C N N 21  
A1LZ1 C29  C N N 22  
A1LZ1 C31  C N N 23  
A1LZ1 C32  C N N 24  
A1LZ1 C35  C N N 25  
A1LZ1 C36  C N N 26  
A1LZ1 C37  C N N 27  
A1LZ1 F20  F N N 28  
A1LZ1 N07  N N N 29  
A1LZ1 N21  N Y N 30  
A1LZ1 N22  N Y N 31  
A1LZ1 N23  N Y N 32  
A1LZ1 N30  N N N 33  
A1LZ1 O24  O N N 34  
A1LZ1 O25  O N N 35  
A1LZ1 O33  O N N 36  
A1LZ1 O34  O N N 37  
A1LZ1 H1   H N N 38  
A1LZ1 H2   H N N 39  
A1LZ1 H3   H N N 40  
A1LZ1 H4   H N N 41  
A1LZ1 H5   H N N 42  
A1LZ1 H6   H N N 43  
A1LZ1 H7   H N N 44  
A1LZ1 H8   H N N 45  
A1LZ1 H9   H N N 46  
A1LZ1 H10  H N N 47  
A1LZ1 H11  H N N 48  
A1LZ1 H12  H N N 49  
A1LZ1 H13  H N N 50  
A1LZ1 H14  H N N 51  
A1LZ1 H15  H N N 52  
A1LZ1 H16  H N N 53  
A1LZ1 H17  H N N 54  
A1LZ1 H18  H N N 55  
A1LZ1 H19  H N N 56  
A1LZ1 H20  H N N 57  
A1LZ1 H21  H N N 58  
A1LZ1 H22  H N N 59  
A1LZ1 H23  H N N 60  
A1LZ1 H24  H N N 61  
A1LZ1 H25  H N N 62  
A1LZ1 H26  H N N 63  
A1LZ1 H27  H N N 64  
A1LZ1 H28  H N N 65  
A1LZ1 H29  H N N 66  
A1LZ1 H30  H N N 67  
A1LZ1 H31  H N N 68  
A1LZ1 H32  H N N 69  
A1LZ1 H33  H N N 70  
A1LZ1 H34  H N N 71  
ALA   N    N N N 72  
ALA   CA   C N S 73  
ALA   C    C N N 74  
ALA   O    O N N 75  
ALA   CB   C N N 76  
ALA   OXT  O N N 77  
ALA   H    H N N 78  
ALA   H2   H N N 79  
ALA   HA   H N N 80  
ALA   HB1  H N N 81  
ALA   HB2  H N N 82  
ALA   HB3  H N N 83  
ALA   HXT  H N N 84  
ARG   N    N N N 85  
ARG   CA   C N S 86  
ARG   C    C N N 87  
ARG   O    O N N 88  
ARG   CB   C N N 89  
ARG   CG   C N N 90  
ARG   CD   C N N 91  
ARG   NE   N N N 92  
ARG   CZ   C N N 93  
ARG   NH1  N N N 94  
ARG   NH2  N N N 95  
ARG   OXT  O N N 96  
ARG   H    H N N 97  
ARG   H2   H N N 98  
ARG   HA   H N N 99  
ARG   HB2  H N N 100 
ARG   HB3  H N N 101 
ARG   HG2  H N N 102 
ARG   HG3  H N N 103 
ARG   HD2  H N N 104 
ARG   HD3  H N N 105 
ARG   HE   H N N 106 
ARG   HH11 H N N 107 
ARG   HH12 H N N 108 
ARG   HH21 H N N 109 
ARG   HH22 H N N 110 
ARG   HXT  H N N 111 
ASN   N    N N N 112 
ASN   CA   C N S 113 
ASN   C    C N N 114 
ASN   O    O N N 115 
ASN   CB   C N N 116 
ASN   CG   C N N 117 
ASN   OD1  O N N 118 
ASN   ND2  N N N 119 
ASN   OXT  O N N 120 
ASN   H    H N N 121 
ASN   H2   H N N 122 
ASN   HA   H N N 123 
ASN   HB2  H N N 124 
ASN   HB3  H N N 125 
ASN   HD21 H N N 126 
ASN   HD22 H N N 127 
ASN   HXT  H N N 128 
ASP   N    N N N 129 
ASP   CA   C N S 130 
ASP   C    C N N 131 
ASP   O    O N N 132 
ASP   CB   C N N 133 
ASP   CG   C N N 134 
ASP   OD1  O N N 135 
ASP   OD2  O N N 136 
ASP   OXT  O N N 137 
ASP   H    H N N 138 
ASP   H2   H N N 139 
ASP   HA   H N N 140 
ASP   HB2  H N N 141 
ASP   HB3  H N N 142 
ASP   HD2  H N N 143 
ASP   HXT  H N N 144 
CYS   N    N N N 145 
CYS   CA   C N R 146 
CYS   C    C N N 147 
CYS   O    O N N 148 
CYS   CB   C N N 149 
CYS   SG   S N N 150 
CYS   OXT  O N N 151 
CYS   H    H N N 152 
CYS   H2   H N N 153 
CYS   HA   H N N 154 
CYS   HB2  H N N 155 
CYS   HB3  H N N 156 
CYS   HG   H N N 157 
CYS   HXT  H N N 158 
GLN   N    N N N 159 
GLN   CA   C N S 160 
GLN   C    C N N 161 
GLN   O    O N N 162 
GLN   CB   C N N 163 
GLN   CG   C N N 164 
GLN   CD   C N N 165 
GLN   OE1  O N N 166 
GLN   NE2  N N N 167 
GLN   OXT  O N N 168 
GLN   H    H N N 169 
GLN   H2   H N N 170 
GLN   HA   H N N 171 
GLN   HB2  H N N 172 
GLN   HB3  H N N 173 
GLN   HG2  H N N 174 
GLN   HG3  H N N 175 
GLN   HE21 H N N 176 
GLN   HE22 H N N 177 
GLN   HXT  H N N 178 
GLU   N    N N N 179 
GLU   CA   C N S 180 
GLU   C    C N N 181 
GLU   O    O N N 182 
GLU   CB   C N N 183 
GLU   CG   C N N 184 
GLU   CD   C N N 185 
GLU   OE1  O N N 186 
GLU   OE2  O N N 187 
GLU   OXT  O N N 188 
GLU   H    H N N 189 
GLU   H2   H N N 190 
GLU   HA   H N N 191 
GLU   HB2  H N N 192 
GLU   HB3  H N N 193 
GLU   HG2  H N N 194 
GLU   HG3  H N N 195 
GLU   HE2  H N N 196 
GLU   HXT  H N N 197 
GLY   N    N N N 198 
GLY   CA   C N N 199 
GLY   C    C N N 200 
GLY   O    O N N 201 
GLY   OXT  O N N 202 
GLY   H    H N N 203 
GLY   H2   H N N 204 
GLY   HA2  H N N 205 
GLY   HA3  H N N 206 
GLY   HXT  H N N 207 
HIS   N    N N N 208 
HIS   CA   C N S 209 
HIS   C    C N N 210 
HIS   O    O N N 211 
HIS   CB   C N N 212 
HIS   CG   C Y N 213 
HIS   ND1  N Y N 214 
HIS   CD2  C Y N 215 
HIS   CE1  C Y N 216 
HIS   NE2  N Y N 217 
HIS   OXT  O N N 218 
HIS   H    H N N 219 
HIS   H2   H N N 220 
HIS   HA   H N N 221 
HIS   HB2  H N N 222 
HIS   HB3  H N N 223 
HIS   HD1  H N N 224 
HIS   HD2  H N N 225 
HIS   HE1  H N N 226 
HIS   HE2  H N N 227 
HIS   HXT  H N N 228 
HOH   O    O N N 229 
HOH   H1   H N N 230 
HOH   H2   H N N 231 
ILE   N    N N N 232 
ILE   CA   C N S 233 
ILE   C    C N N 234 
ILE   O    O N N 235 
ILE   CB   C N S 236 
ILE   CG1  C N N 237 
ILE   CG2  C N N 238 
ILE   CD1  C N N 239 
ILE   OXT  O N N 240 
ILE   H    H N N 241 
ILE   H2   H N N 242 
ILE   HA   H N N 243 
ILE   HB   H N N 244 
ILE   HG12 H N N 245 
ILE   HG13 H N N 246 
ILE   HG21 H N N 247 
ILE   HG22 H N N 248 
ILE   HG23 H N N 249 
ILE   HD11 H N N 250 
ILE   HD12 H N N 251 
ILE   HD13 H N N 252 
ILE   HXT  H N N 253 
LEU   N    N N N 254 
LEU   CA   C N S 255 
LEU   C    C N N 256 
LEU   O    O N N 257 
LEU   CB   C N N 258 
LEU   CG   C N N 259 
LEU   CD1  C N N 260 
LEU   CD2  C N N 261 
LEU   OXT  O N N 262 
LEU   H    H N N 263 
LEU   H2   H N N 264 
LEU   HA   H N N 265 
LEU   HB2  H N N 266 
LEU   HB3  H N N 267 
LEU   HG   H N N 268 
LEU   HD11 H N N 269 
LEU   HD12 H N N 270 
LEU   HD13 H N N 271 
LEU   HD21 H N N 272 
LEU   HD22 H N N 273 
LEU   HD23 H N N 274 
LEU   HXT  H N N 275 
LYS   N    N N N 276 
LYS   CA   C N S 277 
LYS   C    C N N 278 
LYS   O    O N N 279 
LYS   CB   C N N 280 
LYS   CG   C N N 281 
LYS   CD   C N N 282 
LYS   CE   C N N 283 
LYS   NZ   N N N 284 
LYS   OXT  O N N 285 
LYS   H    H N N 286 
LYS   H2   H N N 287 
LYS   HA   H N N 288 
LYS   HB2  H N N 289 
LYS   HB3  H N N 290 
LYS   HG2  H N N 291 
LYS   HG3  H N N 292 
LYS   HD2  H N N 293 
LYS   HD3  H N N 294 
LYS   HE2  H N N 295 
LYS   HE3  H N N 296 
LYS   HZ1  H N N 297 
LYS   HZ2  H N N 298 
LYS   HZ3  H N N 299 
LYS   HXT  H N N 300 
MET   N    N N N 301 
MET   CA   C N S 302 
MET   C    C N N 303 
MET   O    O N N 304 
MET   CB   C N N 305 
MET   CG   C N N 306 
MET   SD   S N N 307 
MET   CE   C N N 308 
MET   OXT  O N N 309 
MET   H    H N N 310 
MET   H2   H N N 311 
MET   HA   H N N 312 
MET   HB2  H N N 313 
MET   HB3  H N N 314 
MET   HG2  H N N 315 
MET   HG3  H N N 316 
MET   HE1  H N N 317 
MET   HE2  H N N 318 
MET   HE3  H N N 319 
MET   HXT  H N N 320 
PHE   N    N N N 321 
PHE   CA   C N S 322 
PHE   C    C N N 323 
PHE   O    O N N 324 
PHE   CB   C N N 325 
PHE   CG   C Y N 326 
PHE   CD1  C Y N 327 
PHE   CD2  C Y N 328 
PHE   CE1  C Y N 329 
PHE   CE2  C Y N 330 
PHE   CZ   C Y N 331 
PHE   OXT  O N N 332 
PHE   H    H N N 333 
PHE   H2   H N N 334 
PHE   HA   H N N 335 
PHE   HB2  H N N 336 
PHE   HB3  H N N 337 
PHE   HD1  H N N 338 
PHE   HD2  H N N 339 
PHE   HE1  H N N 340 
PHE   HE2  H N N 341 
PHE   HZ   H N N 342 
PHE   HXT  H N N 343 
PRO   N    N N N 344 
PRO   CA   C N S 345 
PRO   C    C N N 346 
PRO   O    O N N 347 
PRO   CB   C N N 348 
PRO   CG   C N N 349 
PRO   CD   C N N 350 
PRO   OXT  O N N 351 
PRO   H    H N N 352 
PRO   HA   H N N 353 
PRO   HB2  H N N 354 
PRO   HB3  H N N 355 
PRO   HG2  H N N 356 
PRO   HG3  H N N 357 
PRO   HD2  H N N 358 
PRO   HD3  H N N 359 
PRO   HXT  H N N 360 
SER   N    N N N 361 
SER   CA   C N S 362 
SER   C    C N N 363 
SER   O    O N N 364 
SER   CB   C N N 365 
SER   OG   O N N 366 
SER   OXT  O N N 367 
SER   H    H N N 368 
SER   H2   H N N 369 
SER   HA   H N N 370 
SER   HB2  H N N 371 
SER   HB3  H N N 372 
SER   HG   H N N 373 
SER   HXT  H N N 374 
THR   N    N N N 375 
THR   CA   C N S 376 
THR   C    C N N 377 
THR   O    O N N 378 
THR   CB   C N R 379 
THR   OG1  O N N 380 
THR   CG2  C N N 381 
THR   OXT  O N N 382 
THR   H    H N N 383 
THR   H2   H N N 384 
THR   HA   H N N 385 
THR   HB   H N N 386 
THR   HG1  H N N 387 
THR   HG21 H N N 388 
THR   HG22 H N N 389 
THR   HG23 H N N 390 
THR   HXT  H N N 391 
TYR   N    N N N 392 
TYR   CA   C N S 393 
TYR   C    C N N 394 
TYR   O    O N N 395 
TYR   CB   C N N 396 
TYR   CG   C Y N 397 
TYR   CD1  C Y N 398 
TYR   CD2  C Y N 399 
TYR   CE1  C Y N 400 
TYR   CE2  C Y N 401 
TYR   CZ   C Y N 402 
TYR   OH   O N N 403 
TYR   OXT  O N N 404 
TYR   H    H N N 405 
TYR   H2   H N N 406 
TYR   HA   H N N 407 
TYR   HB2  H N N 408 
TYR   HB3  H N N 409 
TYR   HD1  H N N 410 
TYR   HD2  H N N 411 
TYR   HE1  H N N 412 
TYR   HE2  H N N 413 
TYR   HH   H N N 414 
TYR   HXT  H N N 415 
VAL   N    N N N 416 
VAL   CA   C N S 417 
VAL   C    C N N 418 
VAL   O    O N N 419 
VAL   CB   C N N 420 
VAL   CG1  C N N 421 
VAL   CG2  C N N 422 
VAL   OXT  O N N 423 
VAL   H    H N N 424 
VAL   H2   H N N 425 
VAL   HA   H N N 426 
VAL   HB   H N N 427 
VAL   HG11 H N N 428 
VAL   HG12 H N N 429 
VAL   HG13 H N N 430 
VAL   HG21 H N N 431 
VAL   HG22 H N N 432 
VAL   HG23 H N N 433 
VAL   HXT  H N N 434 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1LZ1 C01 C02  doub Y N 1   
A1LZ1 C01 N07  sing N N 2   
A1LZ1 C01 N21  sing Y N 3   
A1LZ1 C02 C03  sing Y N 4   
A1LZ1 C03 C04  doub Y N 5   
A1LZ1 C03 C08  sing N N 6   
A1LZ1 C04 C05  sing Y N 7   
A1LZ1 C04 C06  sing Y N 8   
A1LZ1 C05 N21  doub Y N 9   
A1LZ1 C05 N23  sing Y N 10  
A1LZ1 C06 C09  sing N N 11  
A1LZ1 C06 N22  doub Y N 12  
A1LZ1 C08 O24  doub N N 13  
A1LZ1 C08 O25  sing N N 14  
A1LZ1 C09 C10  sing N N 15  
A1LZ1 C09 C11  sing N N 16  
A1LZ1 C10 C12  sing N N 17  
A1LZ1 C11 C13  sing N N 18  
A1LZ1 C14 C15  doub Y N 19  
A1LZ1 C14 C19  sing Y N 20  
A1LZ1 C15 C16  sing Y N 21  
A1LZ1 C16 C17  doub Y N 22  
A1LZ1 C16 F20  sing N N 23  
A1LZ1 C17 C18  sing Y N 24  
A1LZ1 C18 C19  doub Y N 25  
A1LZ1 C19 N23  sing N N 26  
A1LZ1 N22 N23  sing Y N 27  
A1LZ1 C28 C29  sing N N 28  
A1LZ1 C29 N30  sing N N 29  
A1LZ1 N30 C31  sing N N 30  
A1LZ1 C31 C32  sing N N 31  
A1LZ1 N07 C28  sing N N 32  
A1LZ1 N07 C32  sing N N 33  
A1LZ1 N30 C26  sing N N 34  
A1LZ1 C26 O33  doub N N 35  
A1LZ1 C26 O34  sing N N 36  
A1LZ1 O34 C27  sing N N 37  
A1LZ1 C27 C35  sing N N 38  
A1LZ1 C35 C36  sing N N 39  
A1LZ1 C36 C37  sing N N 40  
A1LZ1 C10 H1   sing N N 41  
A1LZ1 C10 H2   sing N N 42  
A1LZ1 C11 H3   sing N N 43  
A1LZ1 C11 H4   sing N N 44  
A1LZ1 C12 H5   sing N N 45  
A1LZ1 C12 H6   sing N N 46  
A1LZ1 C12 H7   sing N N 47  
A1LZ1 C02 H8   sing N N 48  
A1LZ1 C09 H9   sing N N 49  
A1LZ1 C13 H10  sing N N 50  
A1LZ1 C13 H11  sing N N 51  
A1LZ1 C13 H12  sing N N 52  
A1LZ1 C14 H13  sing N N 53  
A1LZ1 C15 H14  sing N N 54  
A1LZ1 C17 H15  sing N N 55  
A1LZ1 C18 H16  sing N N 56  
A1LZ1 C27 H17  sing N N 57  
A1LZ1 C27 H18  sing N N 58  
A1LZ1 C28 H19  sing N N 59  
A1LZ1 C28 H20  sing N N 60  
A1LZ1 C29 H21  sing N N 61  
A1LZ1 C29 H22  sing N N 62  
A1LZ1 C31 H23  sing N N 63  
A1LZ1 C31 H24  sing N N 64  
A1LZ1 C32 H25  sing N N 65  
A1LZ1 C32 H26  sing N N 66  
A1LZ1 C35 H27  sing N N 67  
A1LZ1 C35 H28  sing N N 68  
A1LZ1 C36 H29  sing N N 69  
A1LZ1 C36 H30  sing N N 70  
A1LZ1 C37 H31  sing N N 71  
A1LZ1 C37 H32  sing N N 72  
A1LZ1 C37 H33  sing N N 73  
A1LZ1 O25 H34  sing N N 74  
ALA   N   CA   sing N N 75  
ALA   N   H    sing N N 76  
ALA   N   H2   sing N N 77  
ALA   CA  C    sing N N 78  
ALA   CA  CB   sing N N 79  
ALA   CA  HA   sing N N 80  
ALA   C   O    doub N N 81  
ALA   C   OXT  sing N N 82  
ALA   CB  HB1  sing N N 83  
ALA   CB  HB2  sing N N 84  
ALA   CB  HB3  sing N N 85  
ALA   OXT HXT  sing N N 86  
ARG   N   CA   sing N N 87  
ARG   N   H    sing N N 88  
ARG   N   H2   sing N N 89  
ARG   CA  C    sing N N 90  
ARG   CA  CB   sing N N 91  
ARG   CA  HA   sing N N 92  
ARG   C   O    doub N N 93  
ARG   C   OXT  sing N N 94  
ARG   CB  CG   sing N N 95  
ARG   CB  HB2  sing N N 96  
ARG   CB  HB3  sing N N 97  
ARG   CG  CD   sing N N 98  
ARG   CG  HG2  sing N N 99  
ARG   CG  HG3  sing N N 100 
ARG   CD  NE   sing N N 101 
ARG   CD  HD2  sing N N 102 
ARG   CD  HD3  sing N N 103 
ARG   NE  CZ   sing N N 104 
ARG   NE  HE   sing N N 105 
ARG   CZ  NH1  sing N N 106 
ARG   CZ  NH2  doub N N 107 
ARG   NH1 HH11 sing N N 108 
ARG   NH1 HH12 sing N N 109 
ARG   NH2 HH21 sing N N 110 
ARG   NH2 HH22 sing N N 111 
ARG   OXT HXT  sing N N 112 
ASN   N   CA   sing N N 113 
ASN   N   H    sing N N 114 
ASN   N   H2   sing N N 115 
ASN   CA  C    sing N N 116 
ASN   CA  CB   sing N N 117 
ASN   CA  HA   sing N N 118 
ASN   C   O    doub N N 119 
ASN   C   OXT  sing N N 120 
ASN   CB  CG   sing N N 121 
ASN   CB  HB2  sing N N 122 
ASN   CB  HB3  sing N N 123 
ASN   CG  OD1  doub N N 124 
ASN   CG  ND2  sing N N 125 
ASN   ND2 HD21 sing N N 126 
ASN   ND2 HD22 sing N N 127 
ASN   OXT HXT  sing N N 128 
ASP   N   CA   sing N N 129 
ASP   N   H    sing N N 130 
ASP   N   H2   sing N N 131 
ASP   CA  C    sing N N 132 
ASP   CA  CB   sing N N 133 
ASP   CA  HA   sing N N 134 
ASP   C   O    doub N N 135 
ASP   C   OXT  sing N N 136 
ASP   CB  CG   sing N N 137 
ASP   CB  HB2  sing N N 138 
ASP   CB  HB3  sing N N 139 
ASP   CG  OD1  doub N N 140 
ASP   CG  OD2  sing N N 141 
ASP   OD2 HD2  sing N N 142 
ASP   OXT HXT  sing N N 143 
CYS   N   CA   sing N N 144 
CYS   N   H    sing N N 145 
CYS   N   H2   sing N N 146 
CYS   CA  C    sing N N 147 
CYS   CA  CB   sing N N 148 
CYS   CA  HA   sing N N 149 
CYS   C   O    doub N N 150 
CYS   C   OXT  sing N N 151 
CYS   CB  SG   sing N N 152 
CYS   CB  HB2  sing N N 153 
CYS   CB  HB3  sing N N 154 
CYS   SG  HG   sing N N 155 
CYS   OXT HXT  sing N N 156 
GLN   N   CA   sing N N 157 
GLN   N   H    sing N N 158 
GLN   N   H2   sing N N 159 
GLN   CA  C    sing N N 160 
GLN   CA  CB   sing N N 161 
GLN   CA  HA   sing N N 162 
GLN   C   O    doub N N 163 
GLN   C   OXT  sing N N 164 
GLN   CB  CG   sing N N 165 
GLN   CB  HB2  sing N N 166 
GLN   CB  HB3  sing N N 167 
GLN   CG  CD   sing N N 168 
GLN   CG  HG2  sing N N 169 
GLN   CG  HG3  sing N N 170 
GLN   CD  OE1  doub N N 171 
GLN   CD  NE2  sing N N 172 
GLN   NE2 HE21 sing N N 173 
GLN   NE2 HE22 sing N N 174 
GLN   OXT HXT  sing N N 175 
GLU   N   CA   sing N N 176 
GLU   N   H    sing N N 177 
GLU   N   H2   sing N N 178 
GLU   CA  C    sing N N 179 
GLU   CA  CB   sing N N 180 
GLU   CA  HA   sing N N 181 
GLU   C   O    doub N N 182 
GLU   C   OXT  sing N N 183 
GLU   CB  CG   sing N N 184 
GLU   CB  HB2  sing N N 185 
GLU   CB  HB3  sing N N 186 
GLU   CG  CD   sing N N 187 
GLU   CG  HG2  sing N N 188 
GLU   CG  HG3  sing N N 189 
GLU   CD  OE1  doub N N 190 
GLU   CD  OE2  sing N N 191 
GLU   OE2 HE2  sing N N 192 
GLU   OXT HXT  sing N N 193 
GLY   N   CA   sing N N 194 
GLY   N   H    sing N N 195 
GLY   N   H2   sing N N 196 
GLY   CA  C    sing N N 197 
GLY   CA  HA2  sing N N 198 
GLY   CA  HA3  sing N N 199 
GLY   C   O    doub N N 200 
GLY   C   OXT  sing N N 201 
GLY   OXT HXT  sing N N 202 
HIS   N   CA   sing N N 203 
HIS   N   H    sing N N 204 
HIS   N   H2   sing N N 205 
HIS   CA  C    sing N N 206 
HIS   CA  CB   sing N N 207 
HIS   CA  HA   sing N N 208 
HIS   C   O    doub N N 209 
HIS   C   OXT  sing N N 210 
HIS   CB  CG   sing N N 211 
HIS   CB  HB2  sing N N 212 
HIS   CB  HB3  sing N N 213 
HIS   CG  ND1  sing Y N 214 
HIS   CG  CD2  doub Y N 215 
HIS   ND1 CE1  doub Y N 216 
HIS   ND1 HD1  sing N N 217 
HIS   CD2 NE2  sing Y N 218 
HIS   CD2 HD2  sing N N 219 
HIS   CE1 NE2  sing Y N 220 
HIS   CE1 HE1  sing N N 221 
HIS   NE2 HE2  sing N N 222 
HIS   OXT HXT  sing N N 223 
HOH   O   H1   sing N N 224 
HOH   O   H2   sing N N 225 
ILE   N   CA   sing N N 226 
ILE   N   H    sing N N 227 
ILE   N   H2   sing N N 228 
ILE   CA  C    sing N N 229 
ILE   CA  CB   sing N N 230 
ILE   CA  HA   sing N N 231 
ILE   C   O    doub N N 232 
ILE   C   OXT  sing N N 233 
ILE   CB  CG1  sing N N 234 
ILE   CB  CG2  sing N N 235 
ILE   CB  HB   sing N N 236 
ILE   CG1 CD1  sing N N 237 
ILE   CG1 HG12 sing N N 238 
ILE   CG1 HG13 sing N N 239 
ILE   CG2 HG21 sing N N 240 
ILE   CG2 HG22 sing N N 241 
ILE   CG2 HG23 sing N N 242 
ILE   CD1 HD11 sing N N 243 
ILE   CD1 HD12 sing N N 244 
ILE   CD1 HD13 sing N N 245 
ILE   OXT HXT  sing N N 246 
LEU   N   CA   sing N N 247 
LEU   N   H    sing N N 248 
LEU   N   H2   sing N N 249 
LEU   CA  C    sing N N 250 
LEU   CA  CB   sing N N 251 
LEU   CA  HA   sing N N 252 
LEU   C   O    doub N N 253 
LEU   C   OXT  sing N N 254 
LEU   CB  CG   sing N N 255 
LEU   CB  HB2  sing N N 256 
LEU   CB  HB3  sing N N 257 
LEU   CG  CD1  sing N N 258 
LEU   CG  CD2  sing N N 259 
LEU   CG  HG   sing N N 260 
LEU   CD1 HD11 sing N N 261 
LEU   CD1 HD12 sing N N 262 
LEU   CD1 HD13 sing N N 263 
LEU   CD2 HD21 sing N N 264 
LEU   CD2 HD22 sing N N 265 
LEU   CD2 HD23 sing N N 266 
LEU   OXT HXT  sing N N 267 
LYS   N   CA   sing N N 268 
LYS   N   H    sing N N 269 
LYS   N   H2   sing N N 270 
LYS   CA  C    sing N N 271 
LYS   CA  CB   sing N N 272 
LYS   CA  HA   sing N N 273 
LYS   C   O    doub N N 274 
LYS   C   OXT  sing N N 275 
LYS   CB  CG   sing N N 276 
LYS   CB  HB2  sing N N 277 
LYS   CB  HB3  sing N N 278 
LYS   CG  CD   sing N N 279 
LYS   CG  HG2  sing N N 280 
LYS   CG  HG3  sing N N 281 
LYS   CD  CE   sing N N 282 
LYS   CD  HD2  sing N N 283 
LYS   CD  HD3  sing N N 284 
LYS   CE  NZ   sing N N 285 
LYS   CE  HE2  sing N N 286 
LYS   CE  HE3  sing N N 287 
LYS   NZ  HZ1  sing N N 288 
LYS   NZ  HZ2  sing N N 289 
LYS   NZ  HZ3  sing N N 290 
LYS   OXT HXT  sing N N 291 
MET   N   CA   sing N N 292 
MET   N   H    sing N N 293 
MET   N   H2   sing N N 294 
MET   CA  C    sing N N 295 
MET   CA  CB   sing N N 296 
MET   CA  HA   sing N N 297 
MET   C   O    doub N N 298 
MET   C   OXT  sing N N 299 
MET   CB  CG   sing N N 300 
MET   CB  HB2  sing N N 301 
MET   CB  HB3  sing N N 302 
MET   CG  SD   sing N N 303 
MET   CG  HG2  sing N N 304 
MET   CG  HG3  sing N N 305 
MET   SD  CE   sing N N 306 
MET   CE  HE1  sing N N 307 
MET   CE  HE2  sing N N 308 
MET   CE  HE3  sing N N 309 
MET   OXT HXT  sing N N 310 
PHE   N   CA   sing N N 311 
PHE   N   H    sing N N 312 
PHE   N   H2   sing N N 313 
PHE   CA  C    sing N N 314 
PHE   CA  CB   sing N N 315 
PHE   CA  HA   sing N N 316 
PHE   C   O    doub N N 317 
PHE   C   OXT  sing N N 318 
PHE   CB  CG   sing N N 319 
PHE   CB  HB2  sing N N 320 
PHE   CB  HB3  sing N N 321 
PHE   CG  CD1  doub Y N 322 
PHE   CG  CD2  sing Y N 323 
PHE   CD1 CE1  sing Y N 324 
PHE   CD1 HD1  sing N N 325 
PHE   CD2 CE2  doub Y N 326 
PHE   CD2 HD2  sing N N 327 
PHE   CE1 CZ   doub Y N 328 
PHE   CE1 HE1  sing N N 329 
PHE   CE2 CZ   sing Y N 330 
PHE   CE2 HE2  sing N N 331 
PHE   CZ  HZ   sing N N 332 
PHE   OXT HXT  sing N N 333 
PRO   N   CA   sing N N 334 
PRO   N   CD   sing N N 335 
PRO   N   H    sing N N 336 
PRO   CA  C    sing N N 337 
PRO   CA  CB   sing N N 338 
PRO   CA  HA   sing N N 339 
PRO   C   O    doub N N 340 
PRO   C   OXT  sing N N 341 
PRO   CB  CG   sing N N 342 
PRO   CB  HB2  sing N N 343 
PRO   CB  HB3  sing N N 344 
PRO   CG  CD   sing N N 345 
PRO   CG  HG2  sing N N 346 
PRO   CG  HG3  sing N N 347 
PRO   CD  HD2  sing N N 348 
PRO   CD  HD3  sing N N 349 
PRO   OXT HXT  sing N N 350 
SER   N   CA   sing N N 351 
SER   N   H    sing N N 352 
SER   N   H2   sing N N 353 
SER   CA  C    sing N N 354 
SER   CA  CB   sing N N 355 
SER   CA  HA   sing N N 356 
SER   C   O    doub N N 357 
SER   C   OXT  sing N N 358 
SER   CB  OG   sing N N 359 
SER   CB  HB2  sing N N 360 
SER   CB  HB3  sing N N 361 
SER   OG  HG   sing N N 362 
SER   OXT HXT  sing N N 363 
THR   N   CA   sing N N 364 
THR   N   H    sing N N 365 
THR   N   H2   sing N N 366 
THR   CA  C    sing N N 367 
THR   CA  CB   sing N N 368 
THR   CA  HA   sing N N 369 
THR   C   O    doub N N 370 
THR   C   OXT  sing N N 371 
THR   CB  OG1  sing N N 372 
THR   CB  CG2  sing N N 373 
THR   CB  HB   sing N N 374 
THR   OG1 HG1  sing N N 375 
THR   CG2 HG21 sing N N 376 
THR   CG2 HG22 sing N N 377 
THR   CG2 HG23 sing N N 378 
THR   OXT HXT  sing N N 379 
TYR   N   CA   sing N N 380 
TYR   N   H    sing N N 381 
TYR   N   H2   sing N N 382 
TYR   CA  C    sing N N 383 
TYR   CA  CB   sing N N 384 
TYR   CA  HA   sing N N 385 
TYR   C   O    doub N N 386 
TYR   C   OXT  sing N N 387 
TYR   CB  CG   sing N N 388 
TYR   CB  HB2  sing N N 389 
TYR   CB  HB3  sing N N 390 
TYR   CG  CD1  doub Y N 391 
TYR   CG  CD2  sing Y N 392 
TYR   CD1 CE1  sing Y N 393 
TYR   CD1 HD1  sing N N 394 
TYR   CD2 CE2  doub Y N 395 
TYR   CD2 HD2  sing N N 396 
TYR   CE1 CZ   doub Y N 397 
TYR   CE1 HE1  sing N N 398 
TYR   CE2 CZ   sing Y N 399 
TYR   CE2 HE2  sing N N 400 
TYR   CZ  OH   sing N N 401 
TYR   OH  HH   sing N N 402 
TYR   OXT HXT  sing N N 403 
VAL   N   CA   sing N N 404 
VAL   N   H    sing N N 405 
VAL   N   H2   sing N N 406 
VAL   CA  C    sing N N 407 
VAL   CA  CB   sing N N 408 
VAL   CA  HA   sing N N 409 
VAL   C   O    doub N N 410 
VAL   C   OXT  sing N N 411 
VAL   CB  CG1  sing N N 412 
VAL   CB  CG2  sing N N 413 
VAL   CB  HB   sing N N 414 
VAL   CG1 HG11 sing N N 415 
VAL   CG1 HG12 sing N N 416 
VAL   CG1 HG13 sing N N 417 
VAL   CG2 HG21 sing N N 418 
VAL   CG2 HG22 sing N N 419 
VAL   CG2 HG23 sing N N 420 
VAL   OXT HXT  sing N N 421 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121054 1 
'Japan Agency for Medical Research and Development (AMED)' Japan JP22ama121052 2 
'Japan Society for the Promotion of Science (JSPS)'        Japan 15H02896      3 
'Japan Society for the Promotion of Science (JSPS)'        Japan 16K13044      4 
'Japan Society for the Promotion of Science (JSPS)'        Japan 18H03190      5 
'Japan Society for the Promotion of Science (JSPS)'        Japan 21H03354      6 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6KXY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8YU8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020065 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016236 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010230 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . LYS   A 1 8   ? -7.59900  -8.22200  -0.52300  1.000 72.29941 ? 204 LYS   A N   1 
ATOM   2    C CA  . LYS   A 1 8   ? -8.98800  -8.35200  -0.92300  1.000 68.17951 ? 204 LYS   A CA  1 
ATOM   3    C C   . LYS   A 1 8   ? -9.21000  -8.14200  -2.40000  1.000 61.61500 ? 204 LYS   A C   1 
ATOM   4    O O   . LYS   A 1 8   ? -9.20500  -9.11300  -3.11800  1.000 64.71428 ? 204 LYS   A O   1 
ATOM   5    C CB  . LYS   A 1 8   ? -9.87200  -7.40300  -0.14900  1.000 64.59715 ? 204 LYS   A CB  1 
ATOM   6    C CG  . LYS   A 1 8   ? -11.33900 -7.70800  -0.33000  1.000 68.07673 ? 204 LYS   A CG  1 
ATOM   7    C CD  . LYS   A 1 8   ? -12.11600 -6.44200  -0.55500  1.000 68.75306 ? 204 LYS   A CD  1 
ATOM   8    C CE  . LYS   A 1 8   ? -12.83400 -6.47400  -1.88100  1.000 70.72193 ? 204 LYS   A CE  1 
ATOM   9    N NZ  . LYS   A 1 8   ? -12.89200 -5.09500  -2.45200  1.000 73.06430 ? 204 LYS   A NZ  1 
ATOM   10   N N   . SER   A 1 9   ? -9.45400  -6.88600  -2.82700  1.000 66.16903 ? 205 SER   A N   1 
ATOM   11   C CA  . SER   A 1 9   ? -9.68300  -6.56900  -4.23200  1.000 61.55964 ? 205 SER   A CA  1 
ATOM   12   C C   . SER   A 1 9   ? -8.39900  -6.68400  -5.04200  1.000 56.98868 ? 205 SER   A C   1 
ATOM   13   O O   . SER   A 1 9   ? -8.03900  -5.77500  -5.79800  1.000 55.00684 ? 205 SER   A O   1 
ATOM   14   C CB  . SER   A 1 9   ? -10.26800 -5.16400  -4.36300  1.000 61.05864 ? 205 SER   A CB  1 
ATOM   15   O OG  . SER   A 1 9   ? -10.91000 -4.99900  -5.61200  1.000 66.10813 ? 205 SER   A OG  1 
ATOM   16   N N   . LEU   A 1 10  ? -7.71500  -7.81700  -4.89600  1.000 53.10761 ? 206 LEU   A N   1 
ATOM   17   C CA  . LEU   A 1 10  ? -6.41200  -7.99600  -5.52100  1.000 52.86730 ? 206 LEU   A CA  1 
ATOM   18   C C   . LEU   A 1 10  ? -6.51700  -8.03800  -7.04300  1.000 42.44821 ? 206 LEU   A C   1 
ATOM   19   O O   . LEU   A 1 10  ? -5.59400  -7.60000  -7.73900  1.000 39.87708 ? 206 LEU   A O   1 
ATOM   20   C CB  . LEU   A 1 10  ? -5.77200  -9.27000  -4.96100  1.000 49.26207 ? 206 LEU   A CB  1 
ATOM   21   C CG  . LEU   A 1 10  ? -4.60600  -10.01500 -5.60200  1.000 46.13744 ? 206 LEU   A CG  1 
ATOM   22   C CD1 . LEU   A 1 10  ? -3.30900  -9.25900  -5.40100  1.000 43.50762 ? 206 LEU   A CD1 1 
ATOM   23   C CD2 . LEU   A 1 10  ? -4.51500  -11.39800 -4.96700  1.000 42.12983 ? 206 LEU   A CD2 1 
ATOM   24   N N   . ALA   A 1 11  ? -7.64600  -8.51700  -7.57600  1.000 44.43469 ? 207 ALA   A N   1 
ATOM   25   C CA  . ALA   A 1 11  ? -7.76400  -8.72700  -9.01900  1.000 46.90872 ? 207 ALA   A CA  1 
ATOM   26   C C   . ALA   A 1 11  ? -7.79700  -7.41300  -9.78500  1.000 47.83390 ? 207 ALA   A C   1 
ATOM   27   O O   . ALA   A 1 11  ? -7.19400  -7.29800  -10.85900 1.000 42.73834 ? 207 ALA   A O   1 
ATOM   28   C CB  . ALA   A 1 11  ? -9.01900  -9.53000  -9.33700  1.000 42.14918 ? 207 ALA   A CB  1 
ATOM   29   N N   . LYS   A 1 12  ? -8.52700  -6.42100  -9.27500  1.000 45.11455 ? 208 LYS   A N   1 
ATOM   30   C CA  . LYS   A 1 12  ? -8.64100  -5.17200  -10.01500 1.000 47.40194 ? 208 LYS   A CA  1 
ATOM   31   C C   . LYS   A 1 12  ? -7.35500  -4.36600  -9.93200  1.000 41.01659 ? 208 LYS   A C   1 
ATOM   32   O O   . LYS   A 1 12  ? -6.96000  -3.72400  -10.91300 1.000 44.64449 ? 208 LYS   A O   1 
ATOM   33   C CB  . LYS   A 1 12  ? -9.85000  -4.37600  -9.52500  1.000 54.22162 ? 208 LYS   A CB  1 
ATOM   34   C CG  . LYS   A 1 12  ? -11.24800 -4.93200  -9.93100  1.000 56.77771 ? 208 LYS   A CG  1 
ATOM   35   C CD  . LYS   A 1 12  ? -11.33400 -5.63300  -11.31900 1.000 64.10193 ? 208 LYS   A CD  1 
ATOM   36   C CE  . LYS   A 1 12  ? -10.91000 -7.11800  -11.33100 1.000 62.07193 ? 208 LYS   A CE  1 
ATOM   37   N NZ  . LYS   A 1 12  ? -10.94800 -7.70900  -12.70100 1.000 58.01218 ? 208 LYS   A NZ  1 
ATOM   38   N N   . ARG   A 1 13  ? -6.66500  -4.41200  -8.78900  1.000 40.69524 ? 209 ARG   A N   1 
ATOM   39   C CA  . ARG   A 1 13  ? -5.34300  -3.79700  -8.73100  1.000 42.63250 ? 209 ARG   A CA  1 
ATOM   40   C C   . ARG   A 1 13  ? -4.38500  -4.45100  -9.72400  1.000 40.86346 ? 209 ARG   A C   1 
ATOM   41   O O   . ARG   A 1 13  ? -3.55100  -3.77000  -10.33400 1.000 40.04219 ? 209 ARG   A O   1 
ATOM   42   C CB  . ARG   A 1 13  ? -4.77600  -3.86200  -7.31400  1.000 41.87732 ? 209 ARG   A CB  1 
ATOM   43   C CG  . ARG   A 1 13  ? -5.50700  -2.97100  -6.31400  1.000 53.50739 ? 209 ARG   A CG  1 
ATOM   44   C CD  . ARG   A 1 13  ? -5.56600  -3.58600  -4.93100  1.000 52.00456 ? 209 ARG   A CD  1 
ATOM   45   N NE  . ARG   A 1 13  ? -4.42500  -3.15300  -4.13300  1.000 60.73842 ? 209 ARG   A NE  1 
ATOM   46   C CZ  . ARG   A 1 13  ? -4.08600  -3.66700  -2.95800  1.000 59.64659 ? 209 ARG   A CZ  1 
ATOM   47   N NH1 . ARG   A 1 13  ? -4.79600  -4.63000  -2.39400  1.000 65.76193 ? 209 ARG   A NH1 1 
ATOM   48   N NH2 . ARG   A 1 13  ? -3.00900  -3.19900  -2.33200  1.000 58.88733 ? 209 ARG   A NH2 1 
ATOM   49   N N   . ILE   A 1 14  ? -4.49600  -5.76900  -9.90900  1.000 41.81229 ? 210 ILE   A N   1 
ATOM   50   C CA  . ILE   A 1 14  ? -3.62700  -6.45800  -10.86100 1.000 35.09450 ? 210 ILE   A CA  1 
ATOM   51   C C   . ILE   A 1 14  ? -4.00300  -6.08800  -12.29300 1.000 35.16782 ? 210 ILE   A C   1 
ATOM   52   O O   . ILE   A 1 14  ? -3.13500  -5.80200  -13.12600 1.000 35.56453 ? 210 ILE   A O   1 
ATOM   53   C CB  . ILE   A 1 14  ? -3.67800  -7.98100  -10.62400 1.000 33.70587 ? 210 ILE   A CB  1 
ATOM   54   C CG1 . ILE   A 1 14  ? -2.97400  -8.33000  -9.30800  1.000 32.81805 ? 210 ILE   A CG1 1 
ATOM   55   C CG2 . ILE   A 1 14  ? -3.03700  -8.73200  -11.79000 1.000 33.48527 ? 210 ILE   A CG2 1 
ATOM   56   C CD1 . ILE   A 1 14  ? -2.89200  -9.81800  -9.00700  1.000 34.86590 ? 210 ILE   A CD1 1 
ATOM   57   N N   . TYR   A 1 15  ? -5.30200  -6.06500  -12.59700 1.000 34.65129 ? 211 TYR   A N   1 
ATOM   58   C CA  . TYR   A 1 15  ? -5.73800  -5.67700  -13.93400 1.000 37.62093 ? 211 TYR   A CA  1 
ATOM   59   C C   . TYR   A 1 15  ? -5.34100  -4.23700  -14.25300 1.000 39.26777 ? 211 TYR   A C   1 
ATOM   60   O O   . TYR   A 1 15  ? -4.88700  -3.94400  -15.36600 1.000 36.38812 ? 211 TYR   A O   1 
ATOM   61   C CB  . TYR   A 1 15  ? -7.25000  -5.86200  -14.06100 1.000 39.72767 ? 211 TYR   A CB  1 
ATOM   62   C CG  . TYR   A 1 15  ? -7.78700  -5.66400  -15.46300 1.000 41.28683 ? 211 TYR   A CG  1 
ATOM   63   C CD1 . TYR   A 1 15  ? -9.08100  -5.20500  -15.67200 1.000 45.00405 ? 211 TYR   A CD1 1 
ATOM   64   C CD2 . TYR   A 1 15  ? -7.00600  -5.94500  -16.57700 1.000 39.79523 ? 211 TYR   A CD2 1 
ATOM   65   C CE1 . TYR   A 1 15  ? -9.58400  -5.02500  -16.96200 1.000 43.47790 ? 211 TYR   A CE1 1 
ATOM   66   C CE2 . TYR   A 1 15  ? -7.49700  -5.76900  -17.86700 1.000 40.19544 ? 211 TYR   A CE2 1 
ATOM   67   C CZ  . TYR   A 1 15  ? -8.78600  -5.31100  -18.05200 1.000 42.63955 ? 211 TYR   A CZ  1 
ATOM   68   O OH  . TYR   A 1 15  ? -9.27300  -5.14100  -19.33600 1.000 48.56224 ? 211 TYR   A OH  1 
ATOM   69   N N   . GLU   A 1 16  ? -5.50400  -3.32400  -13.29000 1.000 39.45868 ? 212 GLU   A N   1 
ATOM   70   C CA  . GLU   A 1 16  ? -5.12300  -1.93400  -13.52800 1.000 40.56830 ? 212 GLU   A CA  1 
ATOM   71   C C   . GLU   A 1 16  ? -3.61200  -1.79000  -13.67400 1.000 39.31823 ? 212 GLU   A C   1 
ATOM   72   O O   . GLU   A 1 16  ? -3.13800  -0.99900  -14.49600 1.000 37.84018 ? 212 GLU   A O   1 
ATOM   73   C CB  . GLU   A 1 16  ? -5.66500  -1.03800  -12.40800 1.000 41.56436 ? 212 GLU   A CB  1 
ATOM   74   C CG  . GLU   A 1 16  ? -7.19800  -0.95200  -12.39800 1.000 42.58043 ? 212 GLU   A CG  1 
ATOM   75   C CD  . GLU   A 1 16  ? -7.76100  -0.25200  -11.17000 1.000 50.62065 ? 212 GLU   A CD  1 
ATOM   76   O OE1 . GLU   A 1 16  ? -8.98000  0.02100   -11.15000 1.000 48.42953 ? 212 GLU   A OE1 1 
ATOM   77   O OE2 . GLU   A 1 16  ? -6.99500  0.02400   -10.22300 1.000 48.55276 ? 212 GLU   A OE2 1 
ATOM   78   N N   . ALA   A 1 17  ? -2.83800  -2.55800  -12.90100 1.000 36.31106 ? 213 ALA   A N   1 
ATOM   79   C CA  . ALA   A 1 17  ? -1.38700  -2.54100  -13.06600 1.000 37.59872 ? 213 ALA   A CA  1 
ATOM   80   C C   . ALA   A 1 17  ? -0.98900  -3.01300  -14.45900 1.000 35.87253 ? 213 ALA   A C   1 
ATOM   81   O O   . ALA   A 1 17  ? -0.04800  -2.48200  -15.05900 1.000 36.10890 ? 213 ALA   A O   1 
ATOM   82   C CB  . ALA   A 1 17  ? -0.72300  -3.41400  -11.99900 1.000 36.55455 ? 213 ALA   A CB  1 
ATOM   83   N N   . TYR   A 1 18  ? -1.70000  -4.01400  -14.98200 1.000 34.51388 ? 214 TYR   A N   1 
ATOM   84   C CA  . TYR   A 1 18  ? -1.46000  -4.51400  -16.33400 1.000 34.24342 ? 214 TYR   A CA  1 
ATOM   85   C C   . TYR   A 1 18  ? -1.80500  -3.46200  -17.38100 1.000 39.53817 ? 214 TYR   A C   1 
ATOM   86   O O   . TYR   A 1 18  ? -1.01700  -3.19900  -18.30000 1.000 34.84938 ? 214 TYR   A O   1 
ATOM   87   C CB  . TYR   A 1 18  ? -2.29400  -5.77400  -16.53100 1.000 34.92125 ? 214 TYR   A CB  1 
ATOM   88   C CG  . TYR   A 1 18  ? -2.31900  -6.41500  -17.90200 1.000 38.17040 ? 214 TYR   A CG  1 
ATOM   89   C CD1 . TYR   A 1 18  ? -3.26900  -6.04100  -18.84700 1.000 39.71745 ? 214 TYR   A CD1 1 
ATOM   90   C CD2 . TYR   A 1 18  ? -1.45400  -7.45300  -18.22100 1.000 37.12886 ? 214 TYR   A CD2 1 
ATOM   91   C CE1 . TYR   A 1 18  ? -3.32500  -6.64700  -20.08600 1.000 38.71275 ? 214 TYR   A CE1 1 
ATOM   92   C CE2 . TYR   A 1 18  ? -1.50300  -8.06900  -19.46300 1.000 34.16878 ? 214 TYR   A CE2 1 
ATOM   93   C CZ  . TYR   A 1 18  ? -2.44200  -7.66300  -20.38900 1.000 37.60264 ? 214 TYR   A CZ  1 
ATOM   94   O OH  . TYR   A 1 18  ? -2.50100  -8.26700  -21.62600 1.000 38.52005 ? 214 TYR   A OH  1 
ATOM   95   N N   . LEU   A 1 19  ? -2.99700  -2.86700  -17.26500 1.000 36.17808 ? 215 LEU   A N   1 
ATOM   96   C CA  . LEU   A 1 19  ? -3.43100  -1.84900  -18.21500 1.000 38.70007 ? 215 LEU   A CA  1 
ATOM   97   C C   . LEU   A 1 19  ? -2.49000  -0.65200  -18.21200 1.000 41.07767 ? 215 LEU   A C   1 
ATOM   98   O O   . LEU   A 1 19  ? -2.25800  -0.02900  -19.25600 1.000 42.19484 ? 215 LEU   A O   1 
ATOM   99   C CB  . LEU   A 1 19  ? -4.85200  -1.40600  -17.87900 1.000 41.07587 ? 215 LEU   A CB  1 
ATOM   100  C CG  . LEU   A 1 19  ? -5.96800  -2.39700  -18.21100 1.000 39.82540 ? 215 LEU   A CG  1 
ATOM   101  C CD1 . LEU   A 1 19  ? -7.32700  -1.80300  -17.87100 1.000 43.97340 ? 215 LEU   A CD1 1 
ATOM   102  C CD2 . LEU   A 1 19  ? -5.90000  -2.78900  -19.67200 1.000 43.01017 ? 215 LEU   A CD2 1 
ATOM   103  N N   . LYS   A 1 20  ? -1.92700  -0.32600  -17.05100 1.000 35.16850 ? 216 LYS   A N   1 
ATOM   104  C CA  . LYS   A 1 20  ? -1.08500  0.85600   -16.94000 1.000 42.34201 ? 216 LYS   A CA  1 
ATOM   105  C C   . LYS   A 1 20  ? 0.32600   0.61900   -17.47200 1.000 45.31017 ? 216 LYS   A C   1 
ATOM   106  O O   . LYS   A 1 20  ? 0.94700   1.55100   -17.99500 1.000 38.33296 ? 216 LYS   A O   1 
ATOM   107  C CB  . LYS   A 1 20  ? -1.04800  1.31600   -15.47700 1.000 42.97605 ? 216 LYS   A CB  1 
ATOM   108  C CG  . LYS   A 1 20  ? -0.03800  2.40600   -15.15400 1.000 49.07634 ? 216 LYS   A CG  1 
ATOM   109  C CD  . LYS   A 1 20  ? 0.21000   2.49600   -13.65200 1.000 50.69504 ? 216 LYS   A CD  1 
ATOM   110  C CE  . LYS   A 1 20  ? 1.00700   3.74400   -13.29200 1.000 54.72193 ? 216 LYS   A CE  1 
ATOM   111  N NZ  . LYS   A 1 20  ? 2.32600   3.42000   -12.67500 1.000 54.26029 ? 216 LYS   A NZ  1 
ATOM   112  N N   . ASN   A 1 21  ? 0.84100   -0.61000  -17.38700 1.000 37.13569 ? 217 ASN   A N   1 
ATOM   113  C CA  . ASN   A 1 21  ? 2.27300   -0.82600  -17.55500 1.000 37.48502 ? 217 ASN   A CA  1 
ATOM   114  C C   . ASN   A 1 21  ? 2.67700   -1.46600  -18.88100 1.000 36.70617 ? 217 ASN   A C   1 
ATOM   115  O O   . ASN   A 1 21  ? 3.87000   -1.47800  -19.19500 1.000 35.64751 ? 217 ASN   A O   1 
ATOM   116  C CB  . ASN   A 1 21  ? 2.81500   -1.67400  -16.39700 1.000 36.46938 ? 217 ASN   A CB  1 
ATOM   117  C CG  . ASN   A 1 21  ? 3.05600   -0.85200  -15.14300 1.000 40.21986 ? 217 ASN   A CG  1 
ATOM   118  O OD1 . ASN   A 1 21  ? 4.01200   -0.08300  -15.07500 1.000 41.60832 ? 217 ASN   A OD1 1 
ATOM   119  N ND2 . ASN   A 1 21  ? 2.19200   -1.01100  -14.14600 1.000 35.71697 ? 217 ASN   A ND2 1 
ATOM   120  N N   . PHE   A 1 22  ? 1.74700   -1.99700  -19.66600 1.000 35.37336 ? 218 PHE   A N   1 
ATOM   121  C CA  . PHE   A 1 22  ? 2.10200   -2.65200  -20.92200 1.000 38.57869 ? 218 PHE   A CA  1 
ATOM   122  C C   . PHE   A 1 22  ? 1.59500   -1.83500  -22.09800 1.000 36.46878 ? 218 PHE   A C   1 
ATOM   123  O O   . PHE   A 1 22  ? 0.38500   -1.63400  -22.24600 1.000 36.88974 ? 218 PHE   A O   1 
ATOM   124  C CB  . PHE   A 1 22  ? 1.56800   -4.08200  -20.96000 1.000 35.17773 ? 218 PHE   A CB  1 
ATOM   125  C CG  . PHE   A 1 22  ? 2.19700   -4.96000  -19.92800 1.000 33.12816 ? 218 PHE   A CG  1 
ATOM   126  C CD1 . PHE   A 1 22  ? 3.53900   -5.29200  -20.02000 1.000 34.35289 ? 218 PHE   A CD1 1 
ATOM   127  C CD2 . PHE   A 1 22  ? 1.47300   -5.40400  -18.83200 1.000 30.19137 ? 218 PHE   A CD2 1 
ATOM   128  C CE1 . PHE   A 1 22  ? 4.14500   -6.08300  -19.05400 1.000 33.93294 ? 218 PHE   A CE1 1 
ATOM   129  C CE2 . PHE   A 1 22  ? 2.08000   -6.19700  -17.86200 1.000 35.70842 ? 218 PHE   A CE2 1 
ATOM   130  C CZ  . PHE   A 1 22  ? 3.41500   -6.53000  -17.98100 1.000 30.56376 ? 218 PHE   A CZ  1 
ATOM   131  N N   . ASN   A 1 23  ? 2.53200   -1.36500  -22.92800 1.000 38.24770 ? 219 ASN   A N   1 
ATOM   132  C CA  . ASN   A 1 23  ? 2.16500   -0.55900  -24.08700 1.000 41.38782 ? 219 ASN   A CA  1 
ATOM   133  C C   . ASN   A 1 23  ? 1.27600   -1.34400  -25.04300 1.000 45.95589 ? 219 ASN   A C   1 
ATOM   134  O O   . ASN   A 1 23  ? 0.37700   -0.78000  -25.67800 1.000 44.52024 ? 219 ASN   A O   1 
ATOM   135  C CB  . ASN   A 1 23  ? 3.42700   -0.05400  -24.80000 1.000 46.63942 ? 219 ASN   A CB  1 
ATOM   136  C CG  . ASN   A 1 23  ? 4.14100   -1.14400  -25.60800 1.000 50.84512 ? 219 ASN   A CG  1 
ATOM   137  O OD1 . ASN   A 1 23  ? 3.77600   -1.42300  -26.75300 1.000 50.37996 ? 219 ASN   A OD1 1 
ATOM   138  N ND2 . ASN   A 1 23  ? 5.15000   -1.76900  -25.00900 1.000 50.43524 ? 219 ASN   A ND2 1 
ATOM   139  N N   . MET   A 1 24  ? 1.50900   -2.64300  -25.15900 1.000 40.67229 ? 220 MET   A N   1 
ATOM   140  C CA  . MET   A 1 24  ? 0.73500   -3.49800  -26.04200 1.000 39.58618 ? 220 MET   A CA  1 
ATOM   141  C C   . MET   A 1 24  ? -0.04300  -4.49300  -25.19100 1.000 42.82041 ? 220 MET   A C   1 
ATOM   142  O O   . MET   A 1 24  ? 0.45300   -4.96200  -24.15900 1.000 38.62830 ? 220 MET   A O   1 
ATOM   143  C CB  . MET   A 1 24  ? 1.64600   -4.23900  -27.02700 1.000 40.37318 ? 220 MET   A CB  1 
ATOM   144  C CG  . MET   A 1 24  ? 0.90600   -5.16000  -27.98300 1.000 45.22638 ? 220 MET   A CG  1 
ATOM   145  S SD  . MET   A 1 24  ? -0.30100  -4.37400  -29.08500 1.000 50.49393 ? 220 MET   A SD  1 
ATOM   146  C CE  . MET   A 1 24  ? 0.49400   -2.81500  -29.45800 1.000 47.60629 ? 220 MET   A CE  1 
ATOM   147  N N   . ASN   A 1 25  ? -1.27200  -4.78200  -25.60700 1.000 39.37940 ? 221 ASN   A N   1 
ATOM   148  C CA  . ASN   A 1 25  ? -2.09800  -5.79000  -24.95400 1.000 41.70332 ? 221 ASN   A CA  1 
ATOM   149  C C   . ASN   A 1 25  ? -3.02400  -6.38900  -26.00600 1.000 44.05177 ? 221 ASN   A C   1 
ATOM   150  O O   . ASN   A 1 25  ? -2.94800  -6.04400  -27.19000 1.000 41.35241 ? 221 ASN   A O   1 
ATOM   151  C CB  . ASN   A 1 25  ? -2.86100  -5.19200  -23.76200 1.000 39.75019 ? 221 ASN   A CB  1 
ATOM   152  C CG  . ASN   A 1 25  ? -3.77100  -4.03800  -24.15700 1.000 43.41322 ? 221 ASN   A CG  1 
ATOM   153  O OD1 . ASN   A 1 25  ? -4.32800  -4.01000  -25.25200 1.000 41.85437 ? 221 ASN   A OD1 1 
ATOM   154  N ND2 . ASN   A 1 25  ? -3.92900  -3.07900  -23.25100 1.000 43.44144 ? 221 ASN   A ND2 1 
ATOM   155  N N   . LYS   A 1 26  ? -3.93500  -7.25700  -25.56600 1.000 36.39219 ? 222 LYS   A N   1 
ATOM   156  C CA  . LYS   A 1 26  ? -4.72900  -8.02500  -26.51900 1.000 37.81086 ? 222 LYS   A CA  1 
ATOM   157  C C   . LYS   A 1 26  ? -5.80900  -7.18200  -27.18800 1.000 41.19730 ? 222 LYS   A C   1 
ATOM   158  O O   . LYS   A 1 26  ? -6.05800  -7.33800  -28.38900 1.000 42.27530 ? 222 LYS   A O   1 
ATOM   159  C CB  . LYS   A 1 26  ? -5.35100  -9.23900  -25.83200 1.000 38.28218 ? 222 LYS   A CB  1 
ATOM   160  C CG  . LYS   A 1 26  ? -5.63900  -10.36400 -26.79700 1.000 42.55181 ? 222 LYS   A CG  1 
ATOM   161  C CD  . LYS   A 1 26  ? -6.20000  -11.57500 -26.08900 1.000 41.33676 ? 222 LYS   A CD  1 
ATOM   162  C CE  . LYS   A 1 26  ? -6.72100  -12.58200 -27.10300 1.000 42.57220 ? 222 LYS   A CE  1 
ATOM   163  N NZ  . LYS   A 1 26  ? -6.89500  -13.92500 -26.49000 1.000 46.50353 ? 222 LYS   A NZ  1 
ATOM   164  N N   . VAL   A 1 27  ? -6.47100  -6.29800  -26.43600 1.000 41.08624 ? 223 VAL   A N   1 
ATOM   165  C CA  . VAL   A 1 27  ? -7.48200  -5.43500  -27.04600 1.000 41.52368 ? 223 VAL   A CA  1 
ATOM   166  C C   . VAL   A 1 27  ? -6.85500  -4.58400  -28.14500 1.000 44.49059 ? 223 VAL   A C   1 
ATOM   167  O O   . VAL   A 1 27  ? -7.36100  -4.52700  -29.27300 1.000 40.79686 ? 223 VAL   A O   1 
ATOM   168  C CB  . VAL   A 1 27  ? -8.17600  -4.56900  -25.97800 1.000 40.83203 ? 223 VAL   A CB  1 
ATOM   169  C CG1 . VAL   A 1 27  ? -8.66500  -3.25400  -26.58300 1.000 52.66198 ? 223 VAL   A CG1 1 
ATOM   170  C CG2 . VAL   A 1 27  ? -9.34600  -5.31900  -25.38000 1.000 50.42218 ? 223 VAL   A CG2 1 
ATOM   171  N N   . LYS   A 1 28  ? -5.72600  -3.93400  -27.84100 1.000 40.96697 ? 224 LYS   A N   1 
ATOM   172  C CA  . LYS   A 1 28  ? -5.03800  -3.13900  -28.85600 1.000 44.77580 ? 224 LYS   A CA  1 
ATOM   173  C C   . LYS   A 1 28  ? -4.56000  -4.01200  -30.01000 1.000 45.01877 ? 224 LYS   A C   1 
ATOM   174  O O   . LYS   A 1 28  ? -4.70500  -3.64700  -31.18300 1.000 43.29298 ? 224 LYS   A O   1 
ATOM   175  C CB  . LYS   A 1 28  ? -3.85900  -2.38400  -28.24000 1.000 45.69417 ? 224 LYS   A CB  1 
ATOM   176  C CG  . LYS   A 1 28  ? -4.22200  -1.40600  -27.13500 1.000 49.87902 ? 224 LYS   A CG  1 
ATOM   177  C CD  . LYS   A 1 28  ? -3.05700  -0.45900  -26.86700 1.000 49.85347 ? 224 LYS   A CD  1 
ATOM   178  C CE  . LYS   A 1 28  ? -3.14500  0.15700   -25.48700 1.000 52.00365 ? 224 LYS   A CE  1 
ATOM   179  N NZ  . LYS   A 1 28  ? -1.91800  0.93800   -25.15700 1.000 49.84795 ? 224 LYS   A NZ  1 
ATOM   180  N N   . ALA   A 1 29  ? -3.98900  -5.17800  -29.69500 1.000 43.07777 ? 225 ALA   A N   1 
ATOM   181  C CA  . ALA   A 1 29  ? -3.40400  -6.01700  -30.73600 1.000 41.32252 ? 225 ALA   A CA  1 
ATOM   182  C C   . ALA   A 1 29  ? -4.46100  -6.52700  -31.70600 1.000 45.07337 ? 225 ALA   A C   1 
ATOM   183  O O   . ALA   A 1 29  ? -4.22600  -6.57400  -32.92000 1.000 44.14869 ? 225 ALA   A O   1 
ATOM   184  C CB  . ALA   A 1 29  ? -2.64400  -7.18400  -30.10900 1.000 42.23598 ? 225 ALA   A CB  1 
ATOM   185  N N   . ARG   A 1 30  ? -5.63500  -6.91200  -31.19600 1.000 45.17688 ? 226 ARG   A N   1 
ATOM   186  C CA  . ARG   A 1 30  ? -6.65000  -7.48100  -32.07600 1.000 49.71255 ? 226 ARG   A CA  1 
ATOM   187  C C   . ARG   A 1 30  ? -7.22400  -6.43000  -33.01700 1.000 50.08086 ? 226 ARG   A C   1 
ATOM   188  O O   . ARG   A 1 30  ? -7.61100  -6.75800  -34.14400 1.000 54.65726 ? 226 ARG   A O   1 
ATOM   189  C CB  . ARG   A 1 30  ? -7.77400  -8.12700  -31.26500 1.000 49.35981 ? 226 ARG   A CB  1 
ATOM   190  C CG  . ARG   A 1 30  ? -7.40200  -9.44100  -30.57500 1.000 51.98333 ? 226 ARG   A CG  1 
ATOM   191  C CD  . ARG   A 1 30  ? -6.81800  -10.50300 -31.51200 1.000 57.22424 ? 226 ARG   A CD  1 
ATOM   192  N NE  . ARG   A 1 30  ? -5.58000  -11.04100 -30.95500 1.000 63.89193 ? 226 ARG   A NE  1 
ATOM   193  C CZ  . ARG   A 1 30  ? -4.92100  -12.09300 -31.42600 1.000 60.85193 ? 226 ARG   A CZ  1 
ATOM   194  N NH1 . ARG   A 1 30  ? -3.81700  -12.53300 -30.84300 1.000 51.72107 ? 226 ARG   A NH1 1 
ATOM   195  N NH2 . ARG   A 1 30  ? -5.38300  -12.72500 -32.50300 1.000 54.36231 ? 226 ARG   A NH2 1 
ATOM   196  N N   . VAL   A 1 31  ? -7.29200  -5.17000  -32.57400 1.000 51.35234 ? 227 VAL   A N   1 
ATOM   197  C CA  . VAL   A 1 31  ? -7.66100  -4.08000  -33.47900 1.000 54.03561 ? 227 VAL   A CA  1 
ATOM   198  C C   . VAL   A 1 31  ? -6.75900  -4.09300  -34.70800 1.000 52.48768 ? 227 VAL   A C   1 
ATOM   199  O O   . VAL   A 1 31  ? -7.22600  -4.03100  -35.85000 1.000 59.09422 ? 227 VAL   A O   1 
ATOM   200  C CB  . VAL   A 1 31  ? -7.59100  -2.72700  -32.75000 1.000 52.58005 ? 227 VAL   A CB  1 
ATOM   201  C CG1 . VAL   A 1 31  ? -7.52400  -1.58300  -33.75900 1.000 61.04852 ? 227 VAL   A CG1 1 
ATOM   202  C CG2 . VAL   A 1 31  ? -8.78300  -2.55600  -31.82300 1.000 54.89162 ? 227 VAL   A CG2 1 
ATOM   203  N N   . ILE   A 1 32  ? -5.44900  -4.19900  -34.48600 1.000 51.73578 ? 228 ILE   A N   1 
ATOM   204  C CA  . ILE   A 1 32  ? -4.49600  -4.16400  -35.58800 1.000 46.51575 ? 228 ILE   A CA  1 
ATOM   205  C C   . ILE   A 1 32  ? -4.54800  -5.45900  -36.39100 1.000 52.77719 ? 228 ILE   A C   1 
ATOM   206  O O   . ILE   A 1 32  ? -4.48300  -5.44000  -37.62600 1.000 52.20149 ? 228 ILE   A O   1 
ATOM   207  C CB  . ILE   A 1 32  ? -3.08000  -3.88600  -35.05000 1.000 42.80855 ? 228 ILE   A CB  1 
ATOM   208  C CG1 . ILE   A 1 32  ? -3.05900  -2.58600  -34.24400 1.000 44.40400 ? 228 ILE   A CG1 1 
ATOM   209  C CG2 . ILE   A 1 32  ? -2.08500  -3.81800  -36.18700 1.000 41.66156 ? 228 ILE   A CG2 1 
ATOM   210  C CD1 . ILE   A 1 32  ? -1.80800  -2.41100  -33.40300 1.000 37.74411 ? 228 ILE   A CD1 1 
ATOM   211  N N   . LEU   A 1 33  ? -4.66200  -6.60500  -35.71100 1.000 45.81170 ? 229 LEU   A N   1 
ATOM   212  C CA  . LEU   A 1 33  ? -4.65500  -7.88600  -36.41300 1.000 48.18014 ? 229 LEU   A CA  1 
ATOM   213  C C   . LEU   A 1 33  ? -5.95600  -8.17400  -37.14900 1.000 52.93755 ? 229 LEU   A C   1 
ATOM   214  O O   . LEU   A 1 33  ? -5.94100  -8.93500  -38.12200 1.000 51.45325 ? 229 LEU   A O   1 
ATOM   215  C CB  . LEU   A 1 33  ? -4.36700  -9.03900  -35.44900 1.000 46.46738 ? 229 LEU   A CB  1 
ATOM   216  C CG  . LEU   A 1 33  ? -2.96500  -9.14500  -34.85100 1.000 45.56227 ? 229 LEU   A CG  1 
ATOM   217  C CD1 . LEU   A 1 33  ? -3.01700  -9.87900  -33.52300 1.000 43.41821 ? 229 LEU   A CD1 1 
ATOM   218  C CD2 . LEU   A 1 33  ? -2.02200  -9.84400  -35.81700 1.000 44.32971 ? 229 LEU   A CD2 1 
ATOM   219  N N   . SER   A 1 34  ? -7.07900  -7.60100  -36.71000 1.000 55.84631 ? 230 SER   A N   1 
ATOM   220  C CA  . SER   A 1 34  ? -8.32700  -7.80900  -37.43500 1.000 58.50852 ? 230 SER   A CA  1 
ATOM   221  C C   . SER   A 1 34  ? -8.33200  -7.06100  -38.76100 1.000 62.36765 ? 230 SER   A C   1 
ATOM   222  O O   . SER   A 1 34  ? -8.97900  -7.50100  -39.71800 1.000 65.25242 ? 230 SER   A O   1 
ATOM   223  C CB  . SER   A 1 34  ? -9.51700  -7.38100  -36.57700 1.000 57.98641 ? 230 SER   A CB  1 
ATOM   224  O OG  . SER   A 1 34  ? -9.84500  -6.02000  -36.80000 1.000 65.11462 ? 230 SER   A OG  1 
ATOM   225  N N   . GLY   A 1 35  ? -7.61700  -5.94900  -38.84200 1.000 63.61242 ? 231 GLY   A N   1 
ATOM   226  C CA  . GLY   A 1 35  ? -7.55000  -5.15100  -40.04100 1.000 65.77610 ? 231 GLY   A CA  1 
ATOM   227  C C   . GLY   A 1 35  ? -8.21400  -3.78600  -39.96400 1.000 70.81889 ? 231 GLY   A C   1 
ATOM   228  O O   . GLY   A 1 35  ? -8.54900  -3.22700  -41.01700 1.000 72.31804 ? 231 GLY   A O   1 
ATOM   229  N N   . LYS   A 1 36  ? -8.45200  -3.29500  -38.75600 1.000 67.01615 ? 232 LYS   A N   1 
ATOM   230  C CA  . LYS   A 1 36  ? -9.13800  -2.04400  -38.54900 1.000 67.86006 ? 232 LYS   A CA  1 
ATOM   231  C C   . LYS   A 1 36  ? -8.22400  -0.86800  -38.30400 1.000 71.99913 ? 232 LYS   A C   1 
ATOM   232  O O   . LYS   A 1 36  ? -8.68400  0.23500   -38.11900 1.000 75.94193 ? 232 LYS   A O   1 
ATOM   233  C CB  . LYS   A 1 36  ? -10.14200 -2.19300  -37.41200 1.000 71.63052 ? 232 LYS   A CB  1 
ATOM   234  C CG  . LYS   A 1 36  ? -10.83600 -0.92000  -36.98500 1.000 73.95414 ? 232 LYS   A CG  1 
ATOM   235  C CD  . LYS   A 1 36  ? -11.41500 -0.16400  -38.17100 1.000 71.29530 ? 232 LYS   A CD  1 
ATOM   236  C CE  . LYS   A 1 36  ? -12.17500 1.06400   -37.71100 1.000 76.26047 ? 232 LYS   A CE  1 
ATOM   237  N NZ  . LYS   A 1 36  ? -13.43000 0.79000   -36.94800 1.000 72.05127 ? 232 LYS   A NZ  1 
ATOM   238  N N   . ALA   A 1 37  ? -6.91900  -1.08100  -38.33000 1.000 67.29122 ? 233 ALA   A N   1 
ATOM   239  C CA  . ALA   A 1 37  ? -5.98000  0.02300   -38.15100 1.000 70.57674 ? 233 ALA   A CA  1 
ATOM   240  C C   . ALA   A 1 37  ? -5.85000  0.74900   -39.48100 1.000 68.38714 ? 233 ALA   A C   1 
ATOM   241  O O   . ALA   A 1 37  ? -4.90200  0.51700   -40.21000 1.000 60.76377 ? 233 ALA   A O   1 
ATOM   242  C CB  . ALA   A 1 37  ? -4.62900  -0.50500  -37.71900 1.000 61.69440 ? 233 ALA   A CB  1 
ATOM   243  N N   . SER   A 1 38  ? -6.79400  1.62800   -39.78800 1.000 67.55222 ? 234 SER   A N   1 
ATOM   244  C CA  . SER   A 1 38  ? -6.79600  2.32400   -41.06700 1.000 69.45683 ? 234 SER   A CA  1 
ATOM   245  C C   . SER   A 1 38  ? -5.83800  3.47500   -41.17000 1.000 67.03947 ? 234 SER   A C   1 
ATOM   246  O O   . SER   A 1 38  ? -5.32900  3.74600   -42.23200 1.000 71.94668 ? 234 SER   A O   1 
ATOM   247  C CB  . SER   A 1 38  ? -8.19900  2.83500   -41.41400 1.000 69.53246 ? 234 SER   A CB  1 
ATOM   248  O OG  . SER   A 1 38  ? -8.80500  3.49100   -40.32500 1.000 65.76648 ? 234 SER   A OG  1 
ATOM   249  N N   . ASN   A 1 39  ? -5.59900  4.16300   -40.07600 1.000 64.77325 ? 235 ASN   A N   1 
ATOM   250  C CA  . ASN   A 1 39  ? -4.71900  5.33100   -40.14300 1.000 67.68193 ? 235 ASN   A CA  1 
ATOM   251  C C   . ASN   A 1 39  ? -3.26800  4.91300   -40.35900 1.000 66.26175 ? 235 ASN   A C   1 
ATOM   252  O O   . ASN   A 1 39  ? -2.68700  5.16500   -41.41900 1.000 68.03661 ? 235 ASN   A O   1 
ATOM   253  C CB  . ASN   A 1 39  ? -4.86300  6.17900   -38.87500 1.000 64.54479 ? 235 ASN   A CB  1 
ATOM   254  C CG  . ASN   A 1 39  ? -4.39200  7.60500   -39.07900 1.000 65.65193 ? 235 ASN   A CG  1 
ATOM   255  O OD1 . ASN   A 1 39  ? -4.13000  8.02900   -40.20800 1.000 60.84857 ? 235 ASN   A OD1 1 
ATOM   256  N ND2 . ASN   A 1 39  ? -4.29000  8.35800   -37.98900 1.000 59.45537 ? 235 ASN   A ND2 1 
ATOM   257  N N   . ASN   A 1 40  ? -2.66800  4.27900   -39.35900 1.000 60.77072 ? 236 ASN   A N   1 
ATOM   258  C CA  . ASN   A 1 40  ? -1.28000  3.85800   -39.47800 1.000 62.10598 ? 236 ASN   A CA  1 
ATOM   259  C C   . ASN   A 1 40  ? -1.22800  2.33700   -39.50500 1.000 60.78800 ? 236 ASN   A C   1 
ATOM   260  O O   . ASN   A 1 40  ? -0.87000  1.70900   -38.50100 1.000 54.56902 ? 236 ASN   A O   1 
ATOM   261  C CB  . ASN   A 1 40  ? -0.44900  4.42200   -38.32500 1.000 51.00903 ? 236 ASN   A CB  1 
ATOM   262  C CG  . ASN   A 1 40  ? -0.18300  5.90800   -38.47800 1.000 60.31530 ? 236 ASN   A CG  1 
ATOM   263  O OD1 . ASN   A 1 40  ? 0.60200   6.32800   -39.33100 1.000 55.16220 ? 236 ASN   A OD1 1 
ATOM   264  N ND2 . ASN   A 1 40  ? -0.84500  6.71400   -37.65300 1.000 59.29170 ? 236 ASN   A ND2 1 
ATOM   265  N N   . PRO   A 1 41  ? -1.55100  1.71600   -40.63800 1.000 57.80758 ? 237 PRO   A N   1 
ATOM   266  C CA  . PRO   A 1 41  ? -1.74200  0.26800   -40.66400 1.000 59.38835 ? 237 PRO   A CA  1 
ATOM   267  C C   . PRO   A 1 41  ? -0.42000  -0.46400  -40.54400 1.000 56.77368 ? 237 PRO   A C   1 
ATOM   268  O O   . PRO   A 1 41  ? 0.64300   0.10000   -40.84600 1.000 55.48350 ? 237 PRO   A O   1 
ATOM   269  C CB  . PRO   A 1 41  ? -2.39800  0.02900   -42.03300 1.000 57.45259 ? 237 PRO   A CB  1 
ATOM   270  C CG  . PRO   A 1 41  ? -1.87100  1.15100   -42.90500 1.000 63.92952 ? 237 PRO   A CG  1 
ATOM   271  C CD  . PRO   A 1 41  ? -1.37500  2.26600   -41.99300 1.000 60.14436 ? 237 PRO   A CD  1 
ATOM   272  N N   . PRO   A 1 42  ? -0.43900  -1.72200  -40.10200 1.000 51.20736 ? 238 PRO   A N   1 
ATOM   273  C CA  . PRO   A 1 42  ? 0.81400   -2.47400  -39.96100 1.000 49.63238 ? 238 PRO   A CA  1 
ATOM   274  C C   . PRO   A 1 42  ? 1.42600   -2.75400  -41.32600 1.000 54.20141 ? 238 PRO   A C   1 
ATOM   275  O O   . PRO   A 1 42  ? 0.78500   -3.33600  -42.20400 1.000 52.77580 ? 238 PRO   A O   1 
ATOM   276  C CB  . PRO   A 1 42  ? 0.37900   -3.76400  -39.25300 1.000 46.35476 ? 238 PRO   A CB  1 
ATOM   277  C CG  . PRO   A 1 42  ? -1.05100  -3.93900  -39.64800 1.000 48.72161 ? 238 PRO   A CG  1 
ATOM   278  C CD  . PRO   A 1 42  ? -1.62000  -2.54900  -39.78900 1.000 51.98911 ? 238 PRO   A CD  1 
ATOM   279  N N   . PHE   A 1 43  ? 2.66300   -2.30500  -41.50700 1.000 48.85634 ? 239 PHE   A N   1 
ATOM   280  C CA  . PHE   A 1 43  ? 3.42600   -2.69500  -42.68100 1.000 46.24927 ? 239 PHE   A CA  1 
ATOM   281  C C   . PHE   A 1 43  ? 3.74400   -4.18400  -42.60600 1.000 49.02216 ? 239 PHE   A C   1 
ATOM   282  O O   . PHE   A 1 43  ? 4.25800   -4.66800  -41.59200 1.000 46.04344 ? 239 PHE   A O   1 
ATOM   283  C CB  . PHE   A 1 43  ? 4.71600   -1.88700  -42.77200 1.000 45.58289 ? 239 PHE   A CB  1 
ATOM   284  C CG  . PHE   A 1 43  ? 5.38200   -1.97800  -44.10900 1.000 54.27417 ? 239 PHE   A CG  1 
ATOM   285  C CD1 . PHE   A 1 43  ? 4.83800   -1.34200  -45.21500 1.000 53.18847 ? 239 PHE   A CD1 1 
ATOM   286  C CD2 . PHE   A 1 43  ? 6.52500   -2.74400  -44.27500 1.000 53.15651 ? 239 PHE   A CD2 1 
ATOM   287  C CE1 . PHE   A 1 43  ? 5.44500   -1.43800  -46.45700 1.000 56.27697 ? 239 PHE   A CE1 1 
ATOM   288  C CE2 . PHE   A 1 43  ? 7.13300   -2.85000  -45.51500 1.000 56.62424 ? 239 PHE   A CE2 1 
ATOM   289  C CZ  . PHE   A 1 43  ? 6.59200   -2.19400  -46.60700 1.000 55.99112 ? 239 PHE   A CZ  1 
ATOM   290  N N   . VAL   A 1 44  ? 3.44000   -4.91300  -43.67500 1.000 45.12905 ? 240 VAL   A N   1 
ATOM   291  C CA  . VAL   A 1 44  ? 3.67900   -6.35100  -43.71500 1.000 45.36025 ? 240 VAL   A CA  1 
ATOM   292  C C   . VAL   A 1 44  ? 5.10800   -6.60200  -44.17800 1.000 49.33654 ? 240 VAL   A C   1 
ATOM   293  O O   . VAL   A 1 44  ? 5.47700   -6.26400  -45.30800 1.000 49.38174 ? 240 VAL   A O   1 
ATOM   294  C CB  . VAL   A 1 44  ? 2.66800   -7.06100  -44.62500 1.000 47.70824 ? 240 VAL   A CB  1 
ATOM   295  C CG1 . VAL   A 1 44  ? 2.91200   -8.55900  -44.60200 1.000 45.70583 ? 240 VAL   A CG1 1 
ATOM   296  C CG2 . VAL   A 1 44  ? 1.24800   -6.75100  -44.17000 1.000 46.68817 ? 240 VAL   A CG2 1 
ATOM   297  N N   . ILE   A 1 45  ? 5.91100   -7.19300  -43.30100 1.000 44.29717 ? 241 ILE   A N   1 
ATOM   298  C CA  . ILE   A 1 45  ? 7.28000   -7.58700  -43.60300 1.000 45.71626 ? 241 ILE   A CA  1 
ATOM   299  C C   . ILE   A 1 45  ? 7.25100   -9.07200  -43.94300 1.000 50.10590 ? 241 ILE   A C   1 
ATOM   300  O O   . ILE   A 1 45  ? 7.04700   -9.91400  -43.06300 1.000 43.06677 ? 241 ILE   A O   1 
ATOM   301  C CB  . ILE   A 1 45  ? 8.22000   -7.30400  -42.42300 1.000 43.94122 ? 241 ILE   A CB  1 
ATOM   302  C CG1 . ILE   A 1 45  ? 8.18100   -5.82100  -42.04800 1.000 46.70704 ? 241 ILE   A CG1 1 
ATOM   303  C CG2 . ILE   A 1 45  ? 9.63900   -7.75100  -42.74100 1.000 45.62980 ? 241 ILE   A CG2 1 
ATOM   304  C CD1 . ILE   A 1 45  ? 8.79900   -5.52200  -40.69700 1.000 37.83083 ? 241 ILE   A CD1 1 
ATOM   305  N N   . HIS   A 1 46  ? 7.44700   -9.40600  -45.22100 1.000 50.07794 ? 242 HIS   A N   1 
ATOM   306  C CA  . HIS   A 1 46  ? 7.38300   -10.79500 -45.65200 1.000 47.47696 ? 242 HIS   A CA  1 
ATOM   307  C C   . HIS   A 1 46  ? 8.59200   -11.24200 -46.45800 1.000 54.22333 ? 242 HIS   A C   1 
ATOM   308  O O   . HIS   A 1 46  ? 8.65800   -12.41800 -46.83400 1.000 50.38169 ? 242 HIS   A O   1 
ATOM   309  C CB  . HIS   A 1 46  ? 6.11300   -11.04300 -46.48200 1.000 51.91554 ? 242 HIS   A CB  1 
ATOM   310  C CG  . HIS   A 1 46  ? 6.05700   -10.25600 -47.75400 1.000 56.08955 ? 242 HIS   A CG  1 
ATOM   311  N ND1 . HIS   A 1 46  ? 6.71500   -10.65000 -48.90000 1.000 60.07468 ? 242 HIS   A ND1 1 
ATOM   312  C CD2 . HIS   A 1 46  ? 5.43600   -9.09100  -48.05800 1.000 55.56911 ? 242 HIS   A CD2 1 
ATOM   313  C CE1 . HIS   A 1 46  ? 6.49200   -9.76700  -49.85700 1.000 55.91942 ? 242 HIS   A CE1 1 
ATOM   314  N NE2 . HIS   A 1 46  ? 5.72100   -8.81000  -49.37200 1.000 57.52267 ? 242 HIS   A NE2 1 
ATOM   315  N N   . ASP   A 1 47  ? 9.54100   -10.35400 -46.74000 1.000 54.41125 ? 243 ASP   A N   1 
ATOM   316  C CA  . ASP   A 1 47  ? 10.72700  -10.72700 -47.49900 1.000 54.72326 ? 243 ASP   A CA  1 
ATOM   317  C C   . ASP   A 1 47  ? 11.83900  -9.72500  -47.21100 1.000 57.05668 ? 243 ASP   A C   1 
ATOM   318  O O   . ASP   A 1 47  ? 11.68600  -8.80500  -46.39900 1.000 53.48961 ? 243 ASP   A O   1 
ATOM   319  C CB  . ASP   A 1 47  ? 10.41900  -10.82600 -48.99900 1.000 54.89404 ? 243 ASP   A CB  1 
ATOM   320  C CG  . ASP   A 1 47  ? 9.87000   -9.53000  -49.58500 1.000 59.51093 ? 243 ASP   A CG  1 
ATOM   321  O OD1 . ASP   A 1 47  ? 9.43100   -9.55800  -50.75500 1.000 61.09068 ? 243 ASP   A OD1 1 
ATOM   322  O OD2 . ASP   A 1 47  ? 9.86100   -8.49000  -48.89300 1.000 55.66225 ? 243 ASP   A OD2 1 
ATOM   323  N N   . MET   A 1 48  ? 12.96900  -9.92000  -47.89800 1.000 55.84167 ? 244 MET   A N   1 
ATOM   324  C CA  . MET   A 1 48  ? 14.13700  -9.06800  -47.70400 1.000 57.28236 ? 244 MET   A CA  1 
ATOM   325  C C   . MET   A 1 48  ? 13.80200  -7.61300  -47.99000 1.000 58.20026 ? 244 MET   A C   1 
ATOM   326  O O   . MET   A 1 48  ? 14.27500  -6.70200  -47.30000 1.000 59.15270 ? 244 MET   A O   1 
ATOM   327  C CB  . MET   A 1 48  ? 15.26500  -9.51500  -48.63900 1.000 65.15677 ? 244 MET   A CB  1 
ATOM   328  C CG  . MET   A 1 48  ? 16.61600  -8.84900  -48.39200 1.000 66.73374 ? 244 MET   A CG  1 
ATOM   329  S SD  . MET   A 1 48  ? 17.05400  -8.73900  -46.64700 1.000 84.58193 ? 244 MET   A SD  1 
ATOM   330  C CE  . MET   A 1 48  ? 16.71200  -10.43900 -46.16000 1.000 61.90451 ? 244 MET   A CE  1 
ATOM   331  N N   . GLU   A 1 49  ? 12.98300  -7.38600  -49.01600 1.000 58.26810 ? 245 GLU   A N   1 
ATOM   332  C CA  . GLU   A 1 49  ? 12.73000  -6.05300  -49.54200 1.000 60.44362 ? 245 GLU   A CA  1 
ATOM   333  C C   . GLU   A 1 49  ? 11.74800  -5.27500  -48.67300 1.000 57.19941 ? 245 GLU   A C   1 
ATOM   334  O O   . GLU   A 1 49  ? 11.95900  -4.08600  -48.41300 1.000 56.74159 ? 245 GLU   A O   1 
ATOM   335  C CB  . GLU   A 1 49  ? 12.25000  -6.19800  -50.99000 1.000 59.68330 ? 245 GLU   A CB  1 
ATOM   336  C CG  . GLU   A 1 49  ? 11.67800  -4.98700  -51.69000 1.000 66.65664 ? 245 GLU   A CG  1 
ATOM   337  C CD  . GLU   A 1 49  ? 10.16600  -5.01700  -51.71500 1.000 71.76810 ? 245 GLU   A CD  1 
ATOM   338  O OE1 . GLU   A 1 49  ? 9.54000   -3.94300  -51.69900 1.000 79.78193 ? 245 GLU   A OE1 1 
ATOM   339  O OE2 . GLU   A 1 49  ? 9.59300   -6.12400  -51.72400 1.000 71.02797 ? 245 GLU   A OE2 1 
ATOM   340  N N   . THR   A 1 50  ? 10.68200  -5.92600  -48.20100 1.000 53.74245 ? 246 THR   A N   1 
ATOM   341  C CA  . THR   A 1 50  ? 9.74600   -5.24400  -47.31100 1.000 56.55076 ? 246 THR   A CA  1 
ATOM   342  C C   . THR   A 1 50  ? 10.36500  -4.97100  -45.94700 1.000 51.58701 ? 246 THR   A C   1 
ATOM   343  O O   . THR   A 1 50  ? 9.98100   -4.00600  -45.27500 1.000 49.70912 ? 246 THR   A O   1 
ATOM   344  C CB  . THR   A 1 50  ? 8.46400   -6.06300  -47.15300 1.000 52.62075 ? 246 THR   A CB  1 
ATOM   345  O OG1 . THR   A 1 50  ? 8.80000   -7.41900  -46.83900 1.000 47.39033 ? 246 THR   A OG1 1 
ATOM   346  C CG2 . THR   A 1 50  ? 7.64100   -6.02100  -48.43800 1.000 56.18577 ? 246 THR   A CG2 1 
ATOM   347  N N   . LEU   A 1 51  ? 11.31200  -5.80900  -45.51500 1.000 51.96220 ? 247 LEU   A N   1 
ATOM   348  C CA  . LEU   A 1 51  ? 12.05200  -5.50000  -44.29800 1.000 49.08036 ? 247 LEU   A CA  1 
ATOM   349  C C   . LEU   A 1 51  ? 12.83700  -4.20800  -44.46500 1.000 54.67973 ? 247 LEU   A C   1 
ATOM   350  O O   . LEU   A 1 51  ? 12.88400  -3.37700  -43.55000 1.000 46.27990 ? 247 LEU   A O   1 
ATOM   351  C CB  . LEU   A 1 51  ? 12.98500  -6.65700  -43.93300 1.000 47.34719 ? 247 LEU   A CB  1 
ATOM   352  C CG  . LEU   A 1 51  ? 14.06000  -6.36700  -42.88000 1.000 52.01680 ? 247 LEU   A CG  1 
ATOM   353  C CD1 . LEU   A 1 51  ? 13.42900  -5.96000  -41.54600 1.000 46.80616 ? 247 LEU   A CD1 1 
ATOM   354  C CD2 . LEU   A 1 51  ? 14.97600  -7.56400  -42.69800 1.000 50.80178 ? 247 LEU   A CD2 1 
ATOM   355  N N   . CYS   A 1 52  ? 13.43600  -4.01000  -45.64400 1.000 50.13547 ? 248 CYS   A N   1 
ATOM   356  C CA  . CYS   A 1 52  ? 14.21800  -2.80300  -45.88700 1.000 45.65832 ? 248 CYS   A CA  1 
ATOM   357  C C   . CYS   A 1 52  ? 13.33400  -1.56000  -45.90400 1.000 45.83278 ? 248 CYS   A C   1 
ATOM   358  O O   . CYS   A 1 52  ? 13.69200  -0.53300  -45.31600 1.000 48.57348 ? 248 CYS   A O   1 
ATOM   359  C CB  . CYS   A 1 52  ? 15.00800  -2.93900  -47.19100 1.000 50.49929 ? 248 CYS   A CB  1 
ATOM   360  S SG  . CYS   A 1 52  ? 16.38600  -4.11400  -47.09100 1.000 58.59740 ? 248 CYS   A SG  1 
ATOM   361  N N   . MET   A 1 53  ? 12.17500  -1.62600  -46.57200 1.000 45.05120 ? 249 MET   A N   1 
ATOM   362  C CA  . MET   A 1 53  ? 11.24700  -0.49600  -46.53300 1.000 49.22952 ? 249 MET   A CA  1 
ATOM   363  C C   . MET   A 1 53  ? 10.83200  -0.17400  -45.10600 1.000 45.95073 ? 249 MET   A C   1 
ATOM   364  O O   . MET   A 1 53  ? 10.78900  0.99600   -44.71000 1.000 48.21018 ? 249 MET   A O   1 
ATOM   365  C CB  . MET   A 1 53  ? 9.99700   -0.76900  -47.36600 1.000 50.83760 ? 249 MET   A CB  1 
ATOM   366  C CG  . MET   A 1 53  ? 10.11500  -0.53000  -48.85000 1.000 65.32193 ? 249 MET   A CG  1 
ATOM   367  S SD  . MET   A 1 53  ? 9.27000   -1.86500  -49.71600 1.000 76.47955 ? 249 MET   A SD  1 
ATOM   368  C CE  . MET   A 1 53  ? 7.66200   -1.12000  -49.99500 1.000 66.32504 ? 249 MET   A CE  1 
ATOM   369  N N   . ALA   A 1 54  ? 10.49600  -1.20400  -44.32500 1.000 50.07327 ? 250 ALA   A N   1 
ATOM   370  C CA  . ALA   A 1 54  ? 10.06000  -0.98200  -42.95000 1.000 48.58474 ? 250 ALA   A CA  1 
ATOM   371  C C   . ALA   A 1 54  ? 11.13500  -0.25900  -42.15200 1.000 47.97197 ? 250 ALA   A C   1 
ATOM   372  O O   . ALA   A 1 54  ? 10.85000  0.70700   -41.43300 1.000 47.46196 ? 250 ALA   A O   1 
ATOM   373  C CB  . ALA   A 1 54  ? 9.69100   -2.31400  -42.29600 1.000 42.97896 ? 250 ALA   A CB  1 
ATOM   374  N N   . GLU   A 1 55  ? 12.38800  -0.69700  -42.29800 1.000 44.16502 ? 251 GLU   A N   1 
ATOM   375  C CA  . GLU   A 1 55  ? 13.49000  -0.06500  -41.58200 1.000 46.56000 ? 251 GLU   A CA  1 
ATOM   376  C C   . GLU   A 1 55  ? 13.69100  1.37800   -42.02800 1.000 52.36667 ? 251 GLU   A C   1 
ATOM   377  O O   . GLU   A 1 55  ? 14.00900  2.24600   -41.20700 1.000 54.12273 ? 251 GLU   A O   1 
ATOM   378  C CB  . GLU   A 1 55  ? 14.76900  -0.87000  -41.78400 1.000 48.70002 ? 251 GLU   A CB  1 
ATOM   379  C CG  . GLU   A 1 55  ? 14.68000  -2.30500  -41.28400 1.000 49.81120 ? 251 GLU   A CG  1 
ATOM   380  C CD  . GLU   A 1 55  ? 15.89900  -3.11600  -41.66200 1.000 54.34967 ? 251 GLU   A CD  1 
ATOM   381  O OE1 . GLU   A 1 55  ? 16.39200  -3.88400  -40.81200 1.000 51.35394 ? 251 GLU   A OE1 1 
ATOM   382  O OE2 . GLU   A 1 55  ? 16.37300  -2.97100  -42.81300 1.000 54.29430 ? 251 GLU   A OE2 1 
ATOM   383  N N   . LYS   A 1 56  ? 13.52200  1.64800   -43.32700 1.000 52.66254 ? 252 LYS   A N   1 
ATOM   384  C CA  . LYS   A 1 56  ? 13.62800  3.01500   -43.83000 1.000 59.87515 ? 252 LYS   A CA  1 
ATOM   385  C C   . LYS   A 1 56  ? 12.67100  3.94900   -43.10300 1.000 53.19162 ? 252 LYS   A C   1 
ATOM   386  O O   . LYS   A 1 56  ? 13.03500  5.07500   -42.74700 1.000 57.33508 ? 252 LYS   A O   1 
ATOM   387  C CB  . LYS   A 1 56  ? 13.33500  3.05000   -45.33200 1.000 51.72198 ? 252 LYS   A CB  1 
ATOM   388  C CG  . LYS   A 1 56  ? 14.54300  3.21800   -46.22500 1.000 56.07748 ? 252 LYS   A CG  1 
ATOM   389  C CD  . LYS   A 1 56  ? 14.12100  3.19400   -47.68900 1.000 52.93231 ? 252 LYS   A CD  1 
ATOM   390  C CE  . LYS   A 1 56  ? 13.13700  4.32000   -47.98100 1.000 56.98253 ? 252 LYS   A CE  1 
ATOM   391  N NZ  . LYS   A 1 56  ? 12.93600  4.54800   -49.44300 1.000 52.42071 ? 252 LYS   A NZ  1 
ATOM   392  N N   . THR   A 1 57  ? 11.44200  3.49500   -42.87600 1.000 55.19974 ? 253 THR   A N   1 
ATOM   393  C CA  . THR   A 1 57  ? 10.39100  4.34900   -42.34500 1.000 57.41545 ? 253 THR   A CA  1 
ATOM   394  C C   . THR   A 1 57  ? 10.35500  4.37400   -40.82300 1.000 57.76075 ? 253 THR   A C   1 
ATOM   395  O O   . THR   A 1 57  ? 10.01300  5.40700   -40.23700 1.000 60.20418 ? 253 THR   A O   1 
ATOM   396  C CB  . THR   A 1 57  ? 9.03100   3.89100   -42.88400 1.000 58.39460 ? 253 THR   A CB  1 
ATOM   397  O OG1 . THR   A 1 57  ? 9.07200   3.87300   -44.31700 1.000 67.81193 ? 253 THR   A OG1 1 
ATOM   398  C CG2 . THR   A 1 57  ? 7.92100   4.83200   -42.43100 1.000 59.58015 ? 253 THR   A CG2 1 
ATOM   399  N N   . LEU   A 1 58  ? 10.71400  3.27700   -40.15900 1.000 51.23845 ? 254 LEU   A N   1 
ATOM   400  C CA  . LEU   A 1 58  ? 10.53700  3.19500   -38.71500 1.000 52.10958 ? 254 LEU   A CA  1 
ATOM   401  C C   . LEU   A 1 58  ? 11.80700  3.46400   -37.91700 1.000 56.56021 ? 254 LEU   A C   1 
ATOM   402  O O   . LEU   A 1 58  ? 11.71100  3.90600   -36.76700 1.000 59.21662 ? 254 LEU   A O   1 
ATOM   403  C CB  . LEU   A 1 58  ? 9.97100   1.82300   -38.33400 1.000 51.96450 ? 254 LEU   A CB  1 
ATOM   404  C CG  . LEU   A 1 58  ? 8.60900   1.54200   -38.97700 1.000 52.72353 ? 254 LEU   A CG  1 
ATOM   405  C CD1 . LEU   A 1 58  ? 8.08900   0.16600   -38.60400 1.000 48.49368 ? 254 LEU   A CD1 1 
ATOM   406  C CD2 . LEU   A 1 58  ? 7.59900   2.62200   -38.61300 1.000 53.63149 ? 254 LEU   A CD2 1 
ATOM   407  N N   . VAL   A 1 59  ? 12.99000  3.21300   -38.48100 1.000 53.79339 ? 255 VAL   A N   1 
ATOM   408  C CA  . VAL   A 1 59  ? 14.24500  3.46200   -37.77500 1.000 56.35246 ? 255 VAL   A CA  1 
ATOM   409  C C   . VAL   A 1 59  ? 15.27000  4.05400   -38.73800 1.000 66.33397 ? 255 VAL   A C   1 
ATOM   410  O O   . VAL   A 1 59  ? 16.33700  3.47000   -38.96300 1.000 63.43842 ? 255 VAL   A O   1 
ATOM   411  C CB  . VAL   A 1 59  ? 14.78300  2.17400   -37.12100 1.000 59.19243 ? 255 VAL   A CB  1 
ATOM   412  C CG1 . VAL   A 1 59  ? 14.05200  1.88900   -35.82000 1.000 51.73153 ? 255 VAL   A CG1 1 
ATOM   413  C CG2 . VAL   A 1 59  ? 14.64800  0.99500   -38.07200 1.000 54.66574 ? 255 VAL   A CG2 1 
ATOM   414  N N   . ALA   A 1 60  ? 14.95800  5.22800   -39.29900 1.000 64.45549 ? 256 ALA   A N   1 
ATOM   415  C CA  . ALA   A 1 60  ? 15.80300  5.80600   -40.34200 1.000 65.83959 ? 256 ALA   A CA  1 
ATOM   416  C C   . ALA   A 1 60  ? 17.19800  6.14800   -39.83100 1.000 70.56198 ? 256 ALA   A C   1 
ATOM   417  O O   . ALA   A 1 60  ? 18.16300  6.11400   -40.60300 1.000 69.31336 ? 256 ALA   A O   1 
ATOM   418  C CB  . ALA   A 1 60  ? 15.13600  7.04900   -40.93400 1.000 67.99063 ? 256 ALA   A CB  1 
ATOM   419  N N   . LYS   A 1 61  ? 17.32700  6.48900   -38.54400 1.000 73.00519 ? 257 LYS   A N   1 
ATOM   420  C CA  . LYS   A 1 61  ? 18.65100  6.71600   -37.97200 1.000 73.35943 ? 257 LYS   A CA  1 
ATOM   421  C C   . LYS   A 1 61  ? 19.52400  5.47200   -38.07500 1.000 78.00830 ? 257 LYS   A C   1 
ATOM   422  O O   . LYS   A 1 61  ? 20.74500  5.57900   -38.23800 1.000 79.17952 ? 257 LYS   A O   1 
ATOM   423  C CB  . LYS   A 1 61  ? 18.52900  7.14900   -36.50900 1.000 67.75151 ? 257 LYS   A CB  1 
ATOM   424  C CG  . LYS   A 1 61  ? 19.85600  7.48800   -35.84000 1.000 70.77003 ? 257 LYS   A CG  1 
ATOM   425  C CD  . LYS   A 1 61  ? 20.35400  8.87300   -36.22400 1.000 73.26369 ? 257 LYS   A CD  1 
ATOM   426  C CE  . LYS   A 1 61  ? 19.68800  9.94700   -35.37600 1.000 69.44585 ? 257 LYS   A CE  1 
ATOM   427  N NZ  . LYS   A 1 61  ? 20.62700  11.05400  -35.03600 1.000 66.81080 ? 257 LYS   A NZ  1 
ATOM   428  N N   . LEU   A 1 62  ? 18.91400  4.29000   -37.99600 1.000 73.42905 ? 258 LEU   A N   1 
ATOM   429  C CA  . LEU   A 1 62  ? 19.67100  3.04500   -38.00400 1.000 75.70104 ? 258 LEU   A CA  1 
ATOM   430  C C   . LEU   A 1 62  ? 20.10600  2.66700   -39.41500 1.000 75.92803 ? 258 LEU   A C   1 
ATOM   431  O O   . LEU   A 1 62  ? 21.24000  2.21900   -39.62100 1.000 76.14989 ? 258 LEU   A O   1 
ATOM   432  C CB  . LEU   A 1 62  ? 18.82700  1.93400   -37.38300 1.000 70.12870 ? 258 LEU   A CB  1 
ATOM   433  C CG  . LEU   A 1 62  ? 19.49800  1.03000   -36.35200 1.000 76.64194 ? 258 LEU   A CG  1 
ATOM   434  C CD1 . LEU   A 1 62  ? 20.45800  1.83200   -35.48600 1.000 73.43009 ? 258 LEU   A CD1 1 
ATOM   435  C CD2 . LEU   A 1 62  ? 18.43200  0.36600   -35.49200 1.000 70.39783 ? 258 LEU   A CD2 1 
ATOM   436  N N   . VAL   A 1 63  ? 19.21500  2.83700   -40.39400 1.000 74.12101 ? 259 VAL   A N   1 
ATOM   437  C CA  . VAL   A 1 63  ? 19.58900  2.61800   -41.78900 1.000 79.82290 ? 259 VAL   A CA  1 
ATOM   438  C C   . VAL   A 1 63  ? 20.66400  3.61000   -42.21500 1.000 78.87870 ? 259 VAL   A C   1 
ATOM   439  O O   . VAL   A 1 63  ? 21.56900  3.27300   -42.98700 1.000 78.15324 ? 259 VAL   A O   1 
ATOM   440  C CB  . VAL   A 1 63  ? 18.34800  2.70200   -42.69700 1.000 77.63247 ? 259 VAL   A CB  1 
ATOM   441  C CG1 . VAL   A 1 63  ? 18.75300  2.60900   -44.16000 1.000 73.01963 ? 259 VAL   A CG1 1 
ATOM   442  C CG2 . VAL   A 1 63  ? 17.36200  1.59700   -42.34600 1.000 69.77980 ? 259 VAL   A CG2 1 
ATOM   443  N N   . ALA   A 1 64  ? 20.59200  4.84500   -41.71100 1.000 80.27992 ? 260 ALA   A N   1 
ATOM   444  C CA  . ALA   A 1 64  ? 21.62300  5.82300   -42.04200 1.000 81.42960 ? 260 ALA   A CA  1 
ATOM   445  C C   . ALA   A 1 64  ? 22.99500  5.38900   -41.53200 1.000 82.86016 ? 260 ALA   A C   1 
ATOM   446  O O   . ALA   A 1 64  ? 24.01900  5.80400   -42.08700 1.000 84.76185 ? 260 ALA   A O   1 
ATOM   447  C CB  . ALA   A 1 64  ? 21.24400  7.19700   -41.48600 1.000 80.20939 ? 260 ALA   A CB  1 
ATOM   448  N N   . ASN   A 1 65  ? 23.02500  4.54700   -40.52200 1.000 81.05525 ? 261 ASN   A N   1 
ATOM   449  C CA  . ASN   A 1 65  ? 24.28800  4.08800   -39.97800 1.000 85.49325 ? 261 ASN   A CA  1 
ATOM   450  C C   . ASN   A 1 65  ? 24.79000  2.78300   -40.58600 1.000 81.87197 ? 261 ASN   A C   1 
ATOM   451  O O   . ASN   A 1 65  ? 25.61900  2.12800   -40.01100 1.000 86.33675 ? 261 ASN   A O   1 
ATOM   452  C CB  . ASN   A 1 65  ? 24.17200  3.93700   -38.46500 1.000 82.98517 ? 261 ASN   A CB  1 
ATOM   453  C CG  . ASN   A 1 65  ? 23.88400  5.24900   -37.77000 1.000 85.57496 ? 261 ASN   A CG  1 
ATOM   454  O OD1 . ASN   A 1 65  ? 23.94500  6.31000   -38.37500 1.000 82.74646 ? 261 ASN   A OD1 1 
ATOM   455  N ND2 . ASN   A 1 65  ? 23.57700  5.17600   -36.48700 1.000 82.74924 ? 261 ASN   A ND2 1 
ATOM   456  N N   . GLY   A 1 66  ? 24.27700  2.40400   -41.73900 1.000 82.10342 ? 262 GLY   A N   1 
ATOM   457  C CA  . GLY   A 1 66  ? 24.71000  1.18600   -42.39000 1.000 80.98826 ? 262 GLY   A CA  1 
ATOM   458  C C   . GLY   A 1 66  ? 24.28100  -0.12100  -41.76100 1.000 80.94413 ? 262 GLY   A C   1 
ATOM   459  O O   . GLY   A 1 66  ? 25.03800  -1.05900  -41.73300 1.000 78.94745 ? 262 GLY   A O   1 
ATOM   460  N N   . ILE   A 1 67  ? 23.04700  -0.19600  -41.28500 1.000 81.48926 ? 263 ILE   A N   1 
ATOM   461  C CA  . ILE   A 1 67  ? 22.56600  -1.40300  -40.64000 1.000 77.95131 ? 263 ILE   A CA  1 
ATOM   462  C C   . ILE   A 1 67  ? 22.08600  -2.47100  -41.59800 1.000 75.70067 ? 263 ILE   A C   1 
ATOM   463  O O   . ILE   A 1 67  ? 21.88500  -3.59000  -41.21000 1.000 71.30957 ? 263 ILE   A O   1 
ATOM   464  C CB  . ILE   A 1 67  ? 21.51500  -1.11000  -39.57600 1.000 77.38281 ? 263 ILE   A CB  1 
ATOM   465  C CG1 . ILE   A 1 67  ? 21.17000  -2.40300  -38.84500 1.000 74.78659 ? 263 ILE   A CG1 1 
ATOM   466  C CG2 . ILE   A 1 67  ? 20.31800  -0.42800  -40.19400 1.000 73.65668 ? 263 ILE   A CG2 1 
ATOM   467  C CD1 . ILE   A 1 67  ? 20.38400  -2.19600  -37.58000 1.000 74.21821 ? 263 ILE   A CD1 1 
ATOM   468  N N   . GLN   A 1 68  ? 21.91500  -2.12100  -42.85700 1.000 77.50917 ? 264 GLN   A N   1 
ATOM   469  C CA  . GLN   A 1 68  ? 21.54700  -3.11300  -43.83900 1.000 76.85626 ? 264 GLN   A CA  1 
ATOM   470  C C   . GLN   A 1 68  ? 22.81400  -3.79800  -44.35100 1.000 76.25810 ? 264 GLN   A C   1 
ATOM   471  O O   . GLN   A 1 68  ? 22.76800  -4.67500  -45.20300 1.000 75.78179 ? 264 GLN   A O   1 
ATOM   472  C CB  . GLN   A 1 68  ? 20.75900  -2.47900  -44.94200 1.000 73.48305 ? 264 GLN   A CB  1 
ATOM   473  C CG  . GLN   A 1 68  ? 19.93100  -1.35100  -44.41900 1.000 76.19799 ? 264 GLN   A CG  1 
ATOM   474  C CD  . GLN   A 1 68  ? 19.79300  -0.23900  -45.42100 1.000 84.07970 ? 264 GLN   A CD  1 
ATOM   475  O OE1 . GLN   A 1 68  ? 20.65600  0.64400   -45.51000 1.000 84.33593 ? 264 GLN   A OE1 1 
ATOM   476  N NE2 . GLN   A 1 68  ? 18.70800  -0.27200  -46.19200 1.000 77.90581 ? 264 GLN   A NE2 1 
ATOM   477  N N   . ASN   A 1 69  ? 23.94800  -3.35200  -43.83100 1.000 78.82954 ? 265 ASN   A N   1 
ATOM   478  C CA  . ASN   A 1 69  ? 25.23400  -3.97600  -44.13600 1.000 80.89824 ? 265 ASN   A CA  1 
ATOM   479  C C   . ASN   A 1 69  ? 25.46900  -5.11600  -43.15800 1.000 80.85933 ? 265 ASN   A C   1 
ATOM   480  O O   . ASN   A 1 69  ? 26.59800  -5.48400  -42.89400 1.000 81.32642 ? 265 ASN   A O   1 
ATOM   481  C CB  . ASN   A 1 69  ? 26.37500  -2.99900  -43.96600 1.000 82.78869 ? 265 ASN   A CB  1 
ATOM   482  C CG  . ASN   A 1 69  ? 26.35500  -1.91500  -44.99400 1.000 86.94284 ? 265 ASN   A CG  1 
ATOM   483  O OD1 . ASN   A 1 69  ? 25.67200  -2.02500  -46.01100 1.000 85.20123 ? 265 ASN   A OD1 1 
ATOM   484  N ND2 . ASN   A 1 69  ? 27.10700  -0.86100  -44.74600 1.000 85.81283 ? 265 ASN   A ND2 1 
ATOM   485  N N   . LYS   A 1 70  ? 24.37900  -5.61000  -42.58300 1.000 76.51377 ? 266 LYS   A N   1 
ATOM   486  C CA  . LYS   A 1 70  ? 24.34300  -6.71400  -41.66100 1.000 71.66083 ? 266 LYS   A CA  1 
ATOM   487  C C   . LYS   A 1 70  ? 23.27500  -7.64600  -42.16300 1.000 67.96261 ? 266 LYS   A C   1 
ATOM   488  O O   . LYS   A 1 70  ? 22.35300  -7.23600  -42.83000 1.000 68.44289 ? 266 LYS   A O   1 
ATOM   489  C CB  . LYS   A 1 70  ? 23.99500  -6.22900  -40.27300 1.000 72.66880 ? 266 LYS   A CB  1 
ATOM   490  C CG  . LYS   A 1 70  ? 24.95500  -5.20100  -39.72200 1.000 74.03793 ? 266 LYS   A CG  1 
ATOM   491  C CD  . LYS   A 1 70  ? 25.03100  -5.26500  -38.21100 1.000 75.43670 ? 266 LYS   A CD  1 
ATOM   492  C CE  . LYS   A 1 70  ? 26.40300  -5.71000  -37.75200 1.000 78.50407 ? 266 LYS   A CE  1 
ATOM   493  N NZ  . LYS   A 1 70  ? 26.59300  -7.17500  -37.90600 1.000 76.61622 ? 266 LYS   A NZ  1 
ATOM   494  N N   . GLU   A 1 71  ? 23.35100  -8.91500  -41.81500 1.000 61.55826 ? 267 GLU   A N   1 
ATOM   495  C CA  . GLU   A 1 71  ? 22.33600  -9.81900  -42.30200 1.000 59.88137 ? 267 GLU   A CA  1 
ATOM   496  C C   . GLU   A 1 71  ? 20.99100  -9.53400  -41.68900 1.000 61.84343 ? 267 GLU   A C   1 
ATOM   497  O O   . GLU   A 1 71  ? 20.88000  -9.05600  -40.57800 1.000 58.09519 ? 267 GLU   A O   1 
ATOM   498  C CB  . GLU   A 1 71  ? 22.69100  -11.27300 -42.07700 1.000 60.93639 ? 267 GLU   A CB  1 
ATOM   499  C CG  . GLU   A 1 71  ? 24.14600  -11.53400 -41.82000 1.000 64.80054 ? 267 GLU   A CG  1 
ATOM   500  C CD  . GLU   A 1 71  ? 24.41700  -12.99000 -41.60600 1.000 65.27849 ? 267 GLU   A CD  1 
ATOM   501  O OE1 . GLU   A 1 71  ? 23.84100  -13.80500 -42.33200 1.000 64.73547 ? 267 GLU   A OE1 1 
ATOM   502  O OE2 . GLU   A 1 71  ? 25.19900  -13.30000 -40.70900 1.000 65.87911 ? 267 GLU   A OE2 1 
ATOM   503  N N   . ALA   A 1 72  ? 19.96700  -9.84700  -42.44000 1.000 55.34959 ? 268 ALA   A N   1 
ATOM   504  C CA  . ALA   A 1 72  ? 18.60900  -9.61700  -41.95900 1.000 59.76152 ? 268 ALA   A CA  1 
ATOM   505  C C   . ALA   A 1 72  ? 18.36200  -10.32300 -40.63500 1.000 56.19593 ? 268 ALA   A C   1 
ATOM   506  O O   . ALA   A 1 72  ? 17.71800  -9.76500  -39.73900 1.000 54.34541 ? 268 ALA   A O   1 
ATOM   507  C CB  . ALA   A 1 72  ? 17.59500  -10.08500 -42.99200 1.000 60.58401 ? 268 ALA   A CB  1 
ATOM   508  N N   . GLU   A 1 73  ? 18.85000  -11.55800 -40.50500 1.000 52.72741 ? 269 GLU   A N   1 
ATOM   509  C CA  . GLU   A 1 73  ? 18.73900  -12.27500 -39.24000 1.000 52.87802 ? 269 GLU   A CA  1 
ATOM   510  C C   . GLU   A 1 73  ? 19.30700  -11.45400 -38.09000 1.000 56.51691 ? 269 GLU   A C   1 
ATOM   511  O O   . GLU   A 1 73  ? 18.71700  -11.39800 -37.00500 1.000 52.32398 ? 269 GLU   A O   1 
ATOM   512  C CB  . GLU   A 1 73  ? 19.45200  -13.62500 -39.34600 1.000 50.06574 ? 269 GLU   A CB  1 
ATOM   513  C CG  . GLU   A 1 73  ? 18.72400  -14.64800 -40.21100 1.000 53.57760 ? 269 GLU   A CG  1 
ATOM   514  C CD  . GLU   A 1 73  ? 19.08600  -14.55400 -41.68700 1.000 56.62305 ? 269 GLU   A CD  1 
ATOM   515  O OE1 . GLU   A 1 73  ? 19.77900  -13.59100 -42.08100 1.000 59.04240 ? 269 GLU   A OE1 1 
ATOM   516  O OE2 . GLU   A 1 73  ? 18.67600  -15.44900 -42.45300 1.000 54.33986 ? 269 GLU   A OE2 1 
ATOM   517  N N   . VAL   A 1 74  ? 20.44200  -10.78800 -38.31900 1.000 55.00673 ? 270 VAL   A N   1 
ATOM   518  C CA  . VAL   A 1 74  ? 21.05000  -9.97800  -37.27000 1.000 53.87716 ? 270 VAL   A CA  1 
ATOM   519  C C   . VAL   A 1 74  ? 20.18000  -8.76700  -36.95300 1.000 55.57753 ? 270 VAL   A C   1 
ATOM   520  O O   . VAL   A 1 74  ? 20.05200  -8.36600  -35.79100 1.000 53.13395 ? 270 VAL   A O   1 
ATOM   521  C CB  . VAL   A 1 74  ? 22.47700  -9.56800  -37.67800 1.000 56.74305 ? 270 VAL   A CB  1 
ATOM   522  C CG1 . VAL   A 1 74  ? 23.06600  -8.59200  -36.67400 1.000 58.13370 ? 270 VAL   A CG1 1 
ATOM   523  C CG2 . VAL   A 1 74  ? 23.35900  -10.80100 -37.81300 1.000 54.87723 ? 270 VAL   A CG2 1 
ATOM   524  N N   . ARG   A 1 75  ? 19.56000  -8.17100  -37.97500 1.000 58.89930 ? 271 ARG   A N   1 
ATOM   525  C CA  . ARG   A 1 75  ? 18.69200  -7.02200  -37.73800 1.000 58.07445 ? 271 ARG   A CA  1 
ATOM   526  C C   . ARG   A 1 75  ? 17.44100  -7.43300  -36.97000 1.000 52.98363 ? 271 ARG   A C   1 
ATOM   527  O O   . ARG   A 1 75  ? 17.04600  -6.76700  -36.00500 1.000 51.59500 ? 271 ARG   A O   1 
ATOM   528  C CB  . ARG   A 1 75  ? 18.31000  -6.36400  -39.06200 1.000 54.41125 ? 271 ARG   A CB  1 
ATOM   529  C CG  . ARG   A 1 75  ? 19.37300  -5.45100  -39.63900 1.000 62.58346 ? 271 ARG   A CG  1 
ATOM   530  C CD  . ARG   A 1 75  ? 19.64400  -5.81800  -41.08700 1.000 62.36427 ? 271 ARG   A CD  1 
ATOM   531  N NE  . ARG   A 1 75  ? 18.55700  -5.38600  -41.95700 1.000 56.95163 ? 271 ARG   A NE  1 
ATOM   532  C CZ  . ARG   A 1 75  ? 18.49700  -5.62600  -43.25900 1.000 64.13318 ? 271 ARG   A CZ  1 
ATOM   533  N NH1 . ARG   A 1 75  ? 19.43800  -6.32000  -43.87800 1.000 62.49827 ? 271 ARG   A NH1 1 
ATOM   534  N NH2 . ARG   A 1 75  ? 17.46500  -5.16200  -43.95700 1.000 63.65733 ? 271 ARG   A NH2 1 
ATOM   535  N N   . ILE   A 1 76  ? 16.80000  -8.52500  -37.39400 1.000 50.92285 ? 272 ILE   A N   1 
ATOM   536  C CA  . ILE   A 1 76  ? 15.60700  -9.00600  -36.70500 1.000 52.65187 ? 272 ILE   A CA  1 
ATOM   537  C C   . ILE   A 1 76  ? 15.94900  -9.41400  -35.27900 1.000 53.03490 ? 272 ILE   A C   1 
ATOM   538  O O   . ILE   A 1 76  ? 15.20800  -9.11100  -34.33400 1.000 51.00853 ? 272 ILE   A O   1 
ATOM   539  C CB  . ILE   A 1 76  ? 14.96800  -10.16600 -37.49000 1.000 53.23870 ? 272 ILE   A CB  1 
ATOM   540  C CG1 . ILE   A 1 76  ? 14.60000  -9.71500  -38.90500 1.000 48.73397 ? 272 ILE   A CG1 1 
ATOM   541  C CG2 . ILE   A 1 76  ? 13.74000  -10.69700 -36.75800 1.000 48.84564 ? 272 ILE   A CG2 1 
ATOM   542  C CD1 . ILE   A 1 76  ? 14.19300  -10.85000 -39.81700 1.000 50.27854 ? 272 ILE   A CD1 1 
ATOM   543  N N   . PHE   A 1 77  ? 17.07600  -10.11200 -35.10600 1.000 49.78655 ? 273 PHE   A N   1 
ATOM   544  C CA  . PHE   A 1 77  ? 17.57600  -10.43300 -33.77300 1.000 49.57247 ? 273 PHE   A CA  1 
ATOM   545  C C   . PHE   A 1 77  ? 17.64300  -9.19300  -32.89200 1.000 50.31493 ? 273 PHE   A C   1 
ATOM   546  O O   . PHE   A 1 77  ? 17.20400  -9.21000  -31.73600 1.000 51.05052 ? 273 PHE   A O   1 
ATOM   547  C CB  . PHE   A 1 77  ? 18.95400  -11.09300 -33.88700 1.000 49.23776 ? 273 PHE   A CB  1 
ATOM   548  C CG  . PHE   A 1 77  ? 19.74900  -11.09200 -32.60700 1.000 53.67439 ? 273 PHE   A CG  1 
ATOM   549  C CD1 . PHE   A 1 77  ? 19.67300  -12.15800 -31.72900 1.000 54.04083 ? 273 PHE   A CD1 1 
ATOM   550  C CD2 . PHE   A 1 77  ? 20.60500  -10.04100 -32.30400 1.000 54.60199 ? 273 PHE   A CD2 1 
ATOM   551  C CE1 . PHE   A 1 77  ? 20.41100  -12.16300 -30.55600 1.000 54.54982 ? 273 PHE   A CE1 1 
ATOM   552  C CE2 . PHE   A 1 77  ? 21.34100  -10.04100 -31.13600 1.000 58.78269 ? 273 PHE   A CE2 1 
ATOM   553  C CZ  . PHE   A 1 77  ? 21.24500  -11.10500 -30.26100 1.000 59.36596 ? 273 PHE   A CZ  1 
ATOM   554  N N   . HIS   A 1 78  ? 18.19800  -8.10300  -33.42800 1.000 49.29118 ? 274 HIS   A N   1 
ATOM   555  C CA  . HIS   A 1 78  ? 18.36400  -6.89100  -32.63500 1.000 53.87109 ? 274 HIS   A CA  1 
ATOM   556  C C   . HIS   A 1 78  ? 17.01600  -6.27900  -32.27800 1.000 53.80245 ? 274 HIS   A C   1 
ATOM   557  O O   . HIS   A 1 78  ? 16.81000  -5.83700  -31.14200 1.000 50.92491 ? 274 HIS   A O   1 
ATOM   558  C CB  . HIS   A 1 78  ? 19.23400  -5.89200  -33.39400 1.000 60.96410 ? 274 HIS   A CB  1 
ATOM   559  C CG  . HIS   A 1 78  ? 20.69800  -6.04400  -33.12200 1.000 64.30829 ? 274 HIS   A CG  1 
ATOM   560  N ND1 . HIS   A 1 78  ? 21.18200  -6.75300  -32.04300 1.000 64.78284 ? 274 HIS   A ND1 1 
ATOM   561  C CD2 . HIS   A 1 78  ? 21.78400  -5.59700  -33.79600 1.000 66.93735 ? 274 HIS   A CD2 1 
ATOM   562  C CE1 . HIS   A 1 78  ? 22.50300  -6.72800  -32.05900 1.000 65.92313 ? 274 HIS   A CE1 1 
ATOM   563  N NE2 . HIS   A 1 78  ? 22.89400  -6.03300  -33.11200 1.000 68.63695 ? 274 HIS   A NE2 1 
ATOM   564  N N   . CYS   A 1 79  ? 16.08400  -6.25400  -33.23400 1.000 51.11343 ? 275 CYS   A N   1 
ATOM   565  C CA  . CYS   A 1 79  ? 14.74100  -5.76000  -32.95000 1.000 53.94630 ? 275 CYS   A CA  1 
ATOM   566  C C   . CYS   A 1 79  ? 14.07700  -6.58700  -31.85300 1.000 52.33326 ? 275 CYS   A C   1 
ATOM   567  O O   . CYS   A 1 79  ? 13.53400  -6.03800  -30.88600 1.000 49.93890 ? 275 CYS   A O   1 
ATOM   568  C CB  . CYS   A 1 79  ? 13.90200  -5.77500  -34.22800 1.000 55.50154 ? 275 CYS   A CB  1 
ATOM   569  S SG  . CYS   A 1 79  ? 12.18400  -5.24000  -34.01400 1.000 65.12287 ? 275 CYS   A SG  1 
ATOM   570  N N   . CYS   A 1 80  ? 14.12100  -7.91700  -31.98600 1.000 49.79794 ? 276 CYS   A N   1 
ATOM   571  C CA  . CYS   A 1 80  ? 13.54600  -8.79200  -30.97100 1.000 49.38618 ? 276 CYS   A CA  1 
ATOM   572  C C   . CYS   A 1 80  ? 14.21000  -8.56700  -29.61600 1.000 49.66846 ? 276 CYS   A C   1 
ATOM   573  O O   . CYS   A 1 80  ? 13.52900  -8.45400  -28.58800 1.000 45.99236 ? 276 CYS   A O   1 
ATOM   574  C CB  . CYS   A 1 80  ? 13.68000  -10.25200 -31.40600 1.000 47.00810 ? 276 CYS   A CB  1 
ATOM   575  S SG  . CYS   A 1 80  ? 12.58600  -10.73600 -32.76400 1.000 49.95971 ? 276 CYS   A SG  1 
ATOM   576  N N   . GLN   A 1 81  ? 15.54500  -8.49300  -29.60200 1.000 50.83469 ? 277 GLN   A N   1 
ATOM   577  C CA  . GLN   A 1 81  ? 16.28100  -8.19400  -28.37700 1.000 50.41907 ? 277 GLN   A CA  1 
ATOM   578  C C   . GLN   A 1 81  ? 15.73600  -6.95100  -27.68400 1.000 46.95057 ? 277 GLN   A C   1 
ATOM   579  O O   . GLN   A 1 81  ? 15.40400  -6.98000  -26.49400 1.000 44.05307 ? 277 GLN   A O   1 
ATOM   580  C CB  . GLN   A 1 81  ? 17.76800  -8.00700  -28.68500 1.000 52.76035 ? 277 GLN   A CB  1 
ATOM   581  C CG  . GLN   A 1 81  ? 18.64200  -8.01400  -27.44200 1.000 57.40644 ? 277 GLN   A CG  1 
ATOM   582  C CD  . GLN   A 1 81  ? 20.00100  -8.63000  -27.67800 1.000 60.55184 ? 277 GLN   A CD  1 
ATOM   583  O OE1 . GLN   A 1 81  ? 20.41100  -9.54900  -26.96800 1.000 59.46098 ? 277 GLN   A OE1 1 
ATOM   584  N NE2 . GLN   A 1 81  ? 20.71900  -8.11300  -28.67100 1.000 61.02080 ? 277 GLN   A NE2 1 
ATOM   585  N N   . CYS   A 1 82  ? 15.64600  -5.84100  -28.42500 1.000 46.73087 ? 278 CYS   A N   1 
ATOM   586  C CA  . CYS   A 1 82  ? 15.20300  -4.58400  -27.83100 1.000 41.87219 ? 278 CYS   A CA  1 
ATOM   587  C C   . CYS   A 1 82  ? 13.79800  -4.70200  -27.25600 1.000 44.76280 ? 278 CYS   A C   1 
ATOM   588  O O   . CYS   A 1 82  ? 13.50700  -4.14000  -26.19300 1.000 42.71311 ? 278 CYS   A O   1 
ATOM   589  C CB  . CYS   A 1 82  ? 15.26200  -3.46500  -28.86900 1.000 47.48519 ? 278 CYS   A CB  1 
ATOM   590  S SG  . CYS   A 1 82  ? 16.93500  -2.94400  -29.30100 1.000 59.56072 ? 278 CYS   A SG  1 
ATOM   591  N N   . THR   A 1 83  ? 12.91100  -5.43100  -27.94200 1.000 41.00534 ? 279 THR   A N   1 
ATOM   592  C CA  . THR   A 1 83  ? 11.54900  -5.59200  -27.44400 1.000 40.82897 ? 279 THR   A CA  1 
ATOM   593  C C   . THR   A 1 83  ? 11.53100  -6.33800  -26.11400 1.000 39.34975 ? 279 THR   A C   1 
ATOM   594  O O   . THR   A 1 83  ? 10.80700  -5.95400  -25.18800 1.000 37.78907 ? 279 THR   A O   1 
ATOM   595  C CB  . THR   A 1 83  ? 10.68700  -6.31800  -28.47700 1.000 42.86008 ? 279 THR   A CB  1 
ATOM   596  O OG1 . THR   A 1 83  ? 10.64000  -5.55700  -29.69000 1.000 43.40131 ? 279 THR   A OG1 1 
ATOM   597  C CG2 . THR   A 1 83  ? 9.27200   -6.49200  -27.95400 1.000 39.52910 ? 279 THR   A CG2 1 
ATOM   598  N N   . SER   A 1 84  ? 12.32300  -7.40800  -26.00000 1.000 40.26878 ? 280 SER   A N   1 
ATOM   599  C CA  . SER   A 1 84  ? 12.40800  -8.13800  -24.73800 1.000 39.73079 ? 280 SER   A CA  1 
ATOM   600  C C   . SER   A 1 84  ? 12.91100  -7.22800  -23.62500 1.000 40.40301 ? 280 SER   A C   1 
ATOM   601  O O   . SER   A 1 84  ? 12.35200  -7.20700  -22.52200 1.000 41.92423 ? 280 SER   A O   1 
ATOM   602  C CB  . SER   A 1 84  ? 13.32100  -9.35800  -24.89200 1.000 39.61038 ? 280 SER   A CB  1 
ATOM   603  O OG  . SER   A 1 84  ? 12.75400  -10.32300 -25.76100 1.000 42.80543 ? 280 SER   A OG  1 
ATOM   604  N N   . VAL   A 1 85  ? 13.96200  -6.45400  -23.90800 1.000 39.34719 ? 281 VAL   A N   1 
ATOM   605  C CA  . VAL   A 1 85  ? 14.48200  -5.49900  -22.93000 1.000 44.12295 ? 281 VAL   A CA  1 
ATOM   606  C C   . VAL   A 1 85  ? 13.38400  -4.53900  -22.48000 1.000 44.32504 ? 281 VAL   A C   1 
ATOM   607  O O   . VAL   A 1 85  ? 13.18200  -4.31500  -21.28100 1.000 38.21586 ? 281 VAL   A O   1 
ATOM   608  C CB  . VAL   A 1 85  ? 15.68800  -4.74300  -23.51400 1.000 44.85963 ? 281 VAL   A CB  1 
ATOM   609  C CG1 . VAL   A 1 85  ? 16.01400  -3.51700  -22.66000 1.000 46.95835 ? 281 VAL   A CG1 1 
ATOM   610  C CG2 . VAL   A 1 85  ? 16.89000  -5.67600  -23.61400 1.000 46.61265 ? 281 VAL   A CG2 1 
ATOM   611  N N   . GLU   A 1 86  ? 12.65400  -3.96600  -23.44200 1.000 45.05895 ? 282 GLU   A N   1 
ATOM   612  C CA  . GLU   A 1 86  ? 11.51900  -3.10500  -23.11600 1.000 45.94494 ? 282 GLU   A CA  1 
ATOM   613  C C   . GLU   A 1 86  ? 10.51100  -3.82200  -22.22800 1.000 38.75615 ? 282 GLU   A C   1 
ATOM   614  O O   . GLU   A 1 86  ? 10.07400  -3.28400  -21.20400 1.000 43.06917 ? 282 GLU   A O   1 
ATOM   615  C CB  . GLU   A 1 86  ? 10.83900  -2.62100  -24.40100 1.000 45.48898 ? 282 GLU   A CB  1 
ATOM   616  C CG  . GLU   A 1 86  ? 11.64900  -1.68200  -25.29000 1.000 51.23015 ? 282 GLU   A CG  1 
ATOM   617  C CD  . GLU   A 1 86  ? 12.46200  -0.66000  -24.51100 1.000 65.82193 ? 282 GLU   A CD  1 
ATOM   618  O OE1 . GLU   A 1 86  ? 13.59600  -0.35100  -24.93500 1.000 72.29193 ? 282 GLU   A OE1 1 
ATOM   619  O OE2 . GLU   A 1 86  ? 11.95000  -0.12400  -23.50400 1.000 61.88193 ? 282 GLU   A OE2 1 
ATOM   620  N N   . THR   A 1 87  ? 10.12400  -5.03700  -22.61000 1.000 37.09568 ? 283 THR   A N   1 
ATOM   621  C CA  . THR   A 1 87  ? 9.08700   -5.75300  -21.87200 1.000 40.67601 ? 283 THR   A CA  1 
ATOM   622  C C   . THR   A 1 87  ? 9.54800   -6.14600  -20.47300 1.000 39.29050 ? 283 THR   A C   1 
ATOM   623  O O   . THR   A 1 87  ? 8.73600   -6.18000  -19.54000 1.000 36.55575 ? 283 THR   A O   1 
ATOM   624  C CB  . THR   A 1 87  ? 8.64700   -6.99200  -22.65800 1.000 38.21775 ? 283 THR   A CB  1 
ATOM   625  O OG1 . THR   A 1 87  ? 8.42200   -6.62600  -24.02500 1.000 37.62748 ? 283 THR   A OG1 1 
ATOM   626  C CG2 . THR   A 1 87  ? 7.36500   -7.56300  -22.07700 1.000 35.80268 ? 283 THR   A CG2 1 
ATOM   627  N N   . VAL   A 1 88  ? 10.83500  -6.46200  -20.30500 1.000 37.38103 ? 284 VAL   A N   1 
ATOM   628  C CA  . VAL   A 1 88  ? 11.34700  -6.74300  -18.96700 1.000 37.92510 ? 284 VAL   A CA  1 
ATOM   629  C C   . VAL   A 1 88  ? 11.15700  -5.52800  -18.07100 1.000 39.17710 ? 284 VAL   A C   1 
ATOM   630  O O   . VAL   A 1 88  ? 10.77200  -5.65300  -16.90100 1.000 40.37138 ? 284 VAL   A O   1 
ATOM   631  C CB  . VAL   A 1 88  ? 12.82200  -7.17800  -19.03500 1.000 40.11807 ? 284 VAL   A CB  1 
ATOM   632  C CG1 . VAL   A 1 88  ? 13.47200  -7.09400  -17.65400 1.000 38.24783 ? 284 VAL   A CG1 1 
ATOM   633  C CG2 . VAL   A 1 88  ? 12.92700  -8.59100  -19.59200 1.000 38.76844 ? 284 VAL   A CG2 1 
ATOM   634  N N   . THR   A 1 89  ? 11.40200  -4.33200  -18.61200 1.000 37.81475 ? 285 THR   A N   1 
ATOM   635  C CA  . THR   A 1 89  ? 11.17800  -3.11100  -17.84900 1.000 40.57458 ? 285 THR   A CA  1 
ATOM   636  C C   . THR   A 1 89  ? 9.71200   -2.96600  -17.46600 1.000 39.77077 ? 285 THR   A C   1 
ATOM   637  O O   . THR   A 1 89  ? 9.39200   -2.67800  -16.30800 1.000 39.38701 ? 285 THR   A O   1 
ATOM   638  C CB  . THR   A 1 89  ? 11.65300  -1.89800  -18.64800 1.000 43.59632 ? 285 THR   A CB  1 
ATOM   639  O OG1 . THR   A 1 89  ? 13.08000  -1.93400  -18.75800 1.000 48.81887 ? 285 THR   A OG1 1 
ATOM   640  C CG2 . THR   A 1 89  ? 11.22900  -0.60100  -17.96000 1.000 42.54376 ? 285 THR   A CG2 1 
ATOM   641  N N   . GLU   A 1 90  ? 8.80100   -3.16600  -18.42500 1.000 38.28157 ? 286 GLU   A N   1 
ATOM   642  C CA  . GLU   A 1 90  ? 7.37800   -3.09300  -18.09800 1.000 40.46523 ? 286 GLU   A CA  1 
ATOM   643  C C   . GLU   A 1 90  ? 6.99400   -4.15200  -17.07400 1.000 37.87407 ? 286 GLU   A C   1 
ATOM   644  O O   . GLU   A 1 90  ? 6.19400   -3.88500  -16.16900 1.000 34.94745 ? 286 GLU   A O   1 
ATOM   645  C CB  . GLU   A 1 90  ? 6.52000   -3.24400  -19.35300 1.000 37.38763 ? 286 GLU   A CB  1 
ATOM   646  C CG  . GLU   A 1 90  ? 6.93900   -2.40200  -20.54900 1.000 40.88244 ? 286 GLU   A CG  1 
ATOM   647  C CD  . GLU   A 1 90  ? 5.95900   -2.55100  -21.70500 1.000 44.79575 ? 286 GLU   A CD  1 
ATOM   648  O OE1 . GLU   A 1 90  ? 5.46700   -1.52900  -22.23600 1.000 42.23989 ? 286 GLU   A OE1 1 
ATOM   649  O OE2 . GLU   A 1 90  ? 5.66600   -3.71000  -22.06400 1.000 40.21671 ? 286 GLU   A OE2 1 
ATOM   650  N N   . LEU   A 1 91  ? 7.55400   -5.36200  -17.20200 1.000 36.61662 ? 287 LEU   A N   1 
ATOM   651  C CA  . LEU   A 1 91  ? 7.23800   -6.43300  -16.26300 1.000 38.07023 ? 287 LEU   A CA  1 
ATOM   652  C C   . LEU   A 1 91  ? 7.70400   -6.08400  -14.85700 1.000 35.22489 ? 287 LEU   A C   1 
ATOM   653  O O   . LEU   A 1 91  ? 7.03200   -6.41400  -13.87300 1.000 32.93736 ? 287 LEU   A O   1 
ATOM   654  C CB  . LEU   A 1 91  ? 7.87500   -7.74600  -16.73000 1.000 33.55508 ? 287 LEU   A CB  1 
ATOM   655  C CG  . LEU   A 1 91  ? 7.04500   -8.55300  -17.73500 1.000 37.69417 ? 287 LEU   A CG  1 
ATOM   656  C CD1 . LEU   A 1 91  ? 7.90800   -9.58600  -18.44900 1.000 34.29893 ? 287 LEU   A CD1 1 
ATOM   657  C CD2 . LEU   A 1 91  ? 5.85600   -9.21700  -17.04200 1.000 34.92645 ? 287 LEU   A CD2 1 
ATOM   658  N N   . THR   A 1 92  ? 8.85900   -5.42500  -14.74400 1.000 37.03732 ? 288 THR   A N   1 
ATOM   659  C CA  . THR   A 1 92  ? 9.35300   -5.01000  -13.43400 1.000 36.57086 ? 288 THR   A CA  1 
ATOM   660  C C   . THR   A 1 92  ? 8.39200   -4.02700  -12.77800 1.000 37.16865 ? 288 THR   A C   1 
ATOM   661  O O   . THR   A 1 92  ? 8.03300   -4.17700  -11.60300 1.000 39.30396 ? 288 THR   A O   1 
ATOM   662  C CB  . THR   A 1 92  ? 10.74400  -4.38900  -13.57100 1.000 39.85789 ? 288 THR   A CB  1 
ATOM   663  O OG1 . THR   A 1 92  ? 11.66400  -5.37500  -14.05100 1.000 40.10775 ? 288 THR   A OG1 1 
ATOM   664  C CG2 . THR   A 1 92  ? 11.23200  -3.86700  -12.22100 1.000 39.43716 ? 288 THR   A CG2 1 
ATOM   665  N N   . GLU   A 1 93  ? 7.95900   -3.01100  -13.53100 1.000 36.98374 ? 289 GLU   A N   1 
ATOM   666  C CA  . GLU   A 1 93  ? 7.00900   -2.04400  -12.99300 1.000 39.67306 ? 289 GLU   A CA  1 
ATOM   667  C C   . GLU   A 1 93  ? 5.67300   -2.70300  -12.67200 1.000 36.53521 ? 289 GLU   A C   1 
ATOM   668  O O   . GLU   A 1 93  ? 5.04200   -2.38000  -11.65900 1.000 35.17381 ? 289 GLU   A O   1 
ATOM   669  C CB  . GLU   A 1 93  ? 6.82000   -0.89100  -13.98000 1.000 42.27595 ? 289 GLU   A CB  1 
ATOM   670  C CG  . GLU   A 1 93  ? 8.05600   -0.02700  -14.18300 1.000 44.52246 ? 289 GLU   A CG  1 
ATOM   671  C CD  . GLU   A 1 93  ? 8.67900   0.42100   -12.87000 1.000 46.34120 ? 289 GLU   A CD  1 
ATOM   672  O OE1 . GLU   A 1 93  ? 9.86400   0.10200   -12.63600 1.000 51.22025 ? 289 GLU   A OE1 1 
ATOM   673  O OE2 . GLU   A 1 93  ? 7.98400   1.08600   -12.07200 1.000 45.69241 ? 289 GLU   A OE2 1 
ATOM   674  N N   . PHE   A 1 94  ? 5.22200   -3.62300  -13.53300 1.000 34.97454 ? 290 PHE   A N   1 
ATOM   675  C CA  . PHE   A 1 94  ? 4.03100   -4.41300  -13.23800 1.000 34.05712 ? 290 PHE   A CA  1 
ATOM   676  C C   . PHE   A 1 94  ? 4.17300   -5.14000  -11.90200 1.000 36.13454 ? 290 PHE   A C   1 
ATOM   677  O O   . PHE   A 1 94  ? 3.29500   -5.05100  -11.03600 1.000 32.52372 ? 290 PHE   A O   1 
ATOM   678  C CB  . PHE   A 1 94  ? 3.77400   -5.40400  -14.38100 1.000 36.13632 ? 290 PHE   A CB  1 
ATOM   679  C CG  . PHE   A 1 94  ? 2.61700   -6.33700  -14.13900 1.000 31.50701 ? 290 PHE   A CG  1 
ATOM   680  C CD1 . PHE   A 1 94  ? 1.31500   -5.86600  -14.12800 1.000 32.86084 ? 290 PHE   A CD1 1 
ATOM   681  C CD2 . PHE   A 1 94  ? 2.83700   -7.69700  -13.94600 1.000 29.89903 ? 290 PHE   A CD2 1 
ATOM   682  C CE1 . PHE   A 1 94  ? 0.25100   -6.72300  -13.90700 1.000 33.98021 ? 290 PHE   A CE1 1 
ATOM   683  C CE2 . PHE   A 1 94  ? 1.78100   -8.56300  -13.73200 1.000 31.76645 ? 290 PHE   A CE2 1 
ATOM   684  C CZ  . PHE   A 1 94  ? 0.48200   -8.07900  -13.70700 1.000 35.35969 ? 290 PHE   A CZ  1 
ATOM   685  N N   . ALA   A 1 95  ? 5.29400   -5.84400  -11.71200 1.000 33.07088 ? 291 ALA   A N   1 
ATOM   686  C CA  . ALA   A 1 95  ? 5.48200   -6.62500  -10.49300 1.000 36.47940 ? 291 ALA   A CA  1 
ATOM   687  C C   . ALA   A 1 95  ? 5.47300   -5.73000  -9.26000  1.000 40.59343 ? 291 ALA   A C   1 
ATOM   688  O O   . ALA   A 1 95  ? 4.83300   -6.05700  -8.25600  1.000 35.13344 ? 291 ALA   A O   1 
ATOM   689  C CB  . ALA   A 1 95  ? 6.78600   -7.41600  -10.56900 1.000 37.30748 ? 291 ALA   A CB  1 
ATOM   690  N N   . LYS   A 1 96  ? 6.15500   -4.58000  -9.33400  1.000 37.48735 ? 292 LYS   A N   1 
ATOM   691  C CA  . LYS   A 1 96  ? 6.17500   -3.63300  -8.22500  1.000 39.03721 ? 292 LYS   A CA  1 
ATOM   692  C C   . LYS   A 1 96  ? 4.77700   -3.19700  -7.81400  1.000 38.09524 ? 292 LYS   A C   1 
ATOM   693  O O   . LYS   A 1 96  ? 4.59200   -2.73300  -6.68500  1.000 38.92149 ? 292 LYS   A O   1 
ATOM   694  C CB  . LYS   A 1 96  ? 6.99700   -2.39800  -8.59800  1.000 40.59404 ? 292 LYS   A CB  1 
ATOM   695  C CG  . LYS   A 1 96  ? 8.48300   -2.64400  -8.74700  1.000 42.89357 ? 292 LYS   A CG  1 
ATOM   696  C CD  . LYS   A 1 96  ? 9.23900   -1.32900  -8.74700  1.000 50.50013 ? 292 LYS   A CD  1 
ATOM   697  C CE  . LYS   A 1 96  ? 10.52700  -1.44600  -9.52400  1.000 50.11594 ? 292 LYS   A CE  1 
ATOM   698  N NZ  . LYS   A 1 96  ? 11.09500  -0.10900  -9.85200  1.000 55.04944 ? 292 LYS   A NZ  1 
ATOM   699  N N   . ALA   A 1 97  ? 3.79300   -3.33400  -8.70100  1.000 34.14029 ? 293 ALA   A N   1 
ATOM   700  C CA  . ALA   A 1 97  ? 2.42000   -2.95000  -8.41500  1.000 37.18566 ? 293 ALA   A CA  1 
ATOM   701  C C   . ALA   A 1 97  ? 1.53800   -4.12600  -8.02000  1.000 34.69795 ? 293 ALA   A C   1 
ATOM   702  O O   . ALA   A 1 97  ? 0.36600   -3.91600  -7.69400  1.000 35.97793 ? 293 ALA   A O   1 
ATOM   703  C CB  . ALA   A 1 97  ? 1.81300   -2.23000  -9.62200  1.000 35.10051 ? 293 ALA   A CB  1 
ATOM   704  N N   . ILE   A 1 98  ? 2.05700   -5.35100  -8.04700  1.000 36.62647 ? 294 ILE   A N   1 
ATOM   705  C CA  . ILE   A 1 98  ? 1.31800   -6.49500  -7.51700  1.000 34.45039 ? 294 ILE   A CA  1 
ATOM   706  C C   . ILE   A 1 98  ? 1.32100   -6.38600  -5.99700  1.000 37.37919 ? 294 ILE   A C   1 
ATOM   707  O O   . ILE   A 1 98  ? 2.40100   -6.32200  -5.39300  1.000 36.71885 ? 294 ILE   A O   1 
ATOM   708  C CB  . ILE   A 1 98  ? 1.92800   -7.83500  -7.96300  1.000 34.74958 ? 294 ILE   A CB  1 
ATOM   709  C CG1 . ILE   A 1 98  ? 1.94400   -7.95200  -9.48800  1.000 31.91725 ? 294 ILE   A CG1 1 
ATOM   710  C CG2 . ILE   A 1 98  ? 1.14800   -8.99600  -7.35600  1.000 29.48386 ? 294 ILE   A CG2 1 
ATOM   711  C CD1 . ILE   A 1 98  ? 2.55500   -9.25300  -9.98300  1.000 32.98230 ? 294 ILE   A CD1 1 
ATOM   712  N N   . PRO   A 1 99  ? 0.15100   -6.36300  -5.34000  1.000 37.15363 ? 295 PRO   A N   1 
ATOM   713  C CA  . PRO   A 1 99  ? 0.11800   -6.25200  -3.87200  1.000 38.56076 ? 295 PRO   A CA  1 
ATOM   714  C C   . PRO   A 1 99  ? 0.98300   -7.29000  -3.17600  1.000 40.02833 ? 295 PRO   A C   1 
ATOM   715  O O   . PRO   A 1 99  ? 0.83300   -8.49400  -3.41000  1.000 42.46843 ? 295 PRO   A O   1 
ATOM   716  C CB  . PRO   A 1 99  ? -1.36700  -6.45300  -3.54300  1.000 40.18076 ? 295 PRO   A CB  1 
ATOM   717  C CG  . PRO   A 1 99  ? -2.07800  -5.93200  -4.75300  1.000 41.67126 ? 295 PRO   A CG  1 
ATOM   718  C CD  . PRO   A 1 99  ? -1.20100  -6.32500  -5.92700  1.000 35.51015 ? 295 PRO   A CD  1 
ATOM   719  N N   . GLY   A 1 100 ? 1.90700   -6.82800  -2.33300  1.000 39.96339 ? 296 GLY   A N   1 
ATOM   720  C CA  . GLY   A 1 100 ? 2.81300   -7.68500  -1.60400  1.000 39.12241 ? 296 GLY   A CA  1 
ATOM   721  C C   . GLY   A 1 100 ? 4.20200   -7.78500  -2.20600  1.000 42.39108 ? 296 GLY   A C   1 
ATOM   722  O O   . GLY   A 1 100 ? 5.16500   -8.04400  -1.47600  1.000 44.97966 ? 296 GLY   A O   1 
ATOM   723  N N   . PHE   A 1 101 ? 4.33000   -7.57700  -3.52000  1.000 36.82134 ? 297 PHE   A N   1 
ATOM   724  C CA  . PHE   A 1 101 ? 5.62100   -7.75400  -4.17500  1.000 38.91214 ? 297 PHE   A CA  1 
ATOM   725  C C   . PHE   A 1 101 ? 6.66200   -6.78700  -3.62500  1.000 43.25352 ? 297 PHE   A C   1 
ATOM   726  O O   . PHE   A 1 101 ? 7.80200   -7.17700  -3.35100  1.000 42.03595 ? 297 PHE   A O   1 
ATOM   727  C CB  . PHE   A 1 101 ? 5.46900   -7.57300  -5.68400  1.000 34.88696 ? 297 PHE   A CB  1 
ATOM   728  C CG  . PHE   A 1 101 ? 6.68500   -7.97200  -6.47300  1.000 38.42526 ? 297 PHE   A CG  1 
ATOM   729  C CD1 . PHE   A 1 101 ? 6.77500   -9.23000  -7.05000  1.000 39.03617 ? 297 PHE   A CD1 1 
ATOM   730  C CD2 . PHE   A 1 101 ? 7.73900   -7.08900  -6.64100  1.000 38.15687 ? 297 PHE   A CD2 1 
ATOM   731  C CE1 . PHE   A 1 101 ? 7.89000   -9.59300  -7.77600  1.000 38.20588 ? 297 PHE   A CE1 1 
ATOM   732  C CE2 . PHE   A 1 101 ? 8.85900   -7.45300  -7.36600  1.000 39.16484 ? 297 PHE   A CE2 1 
ATOM   733  C CZ  . PHE   A 1 101 ? 8.93300   -8.70300  -7.93200  1.000 36.90219 ? 297 PHE   A CZ  1 
ATOM   734  N N   . ALA   A 1 102 ? 6.29000   -5.51300  -3.46700  1.000 40.35260 ? 298 ALA   A N   1 
ATOM   735  C CA  . ALA   A 1 102 ? 7.25400   -4.50200  -3.04500  1.000 46.65944 ? 298 ALA   A CA  1 
ATOM   736  C C   . ALA   A 1 102 ? 7.78600   -4.74700  -1.63600  1.000 48.38546 ? 298 ALA   A C   1 
ATOM   737  O O   . ALA   A 1 102 ? 8.81800   -4.17400  -1.26800  1.000 49.04301 ? 298 ALA   A O   1 
ATOM   738  C CB  . ALA   A 1 102 ? 6.62800   -3.11000  -3.13000  1.000 43.76058 ? 298 ALA   A CB  1 
ATOM   739  N N   . ASN   A 1 103 ? 7.12100   -5.58500  -0.84500  1.000 45.72771 ? 299 ASN   A N   1 
ATOM   740  C CA  . ASN   A 1 103 ? 7.56900   -5.87400  0.51000   1.000 47.45980 ? 299 ASN   A CA  1 
ATOM   741  C C   . ASN   A 1 103 ? 8.56500   -7.02600  0.57000   1.000 50.25493 ? 299 ASN   A C   1 
ATOM   742  O O   . ASN   A 1 103 ? 9.09200   -7.31900  1.65000   1.000 44.49473 ? 299 ASN   A O   1 
ATOM   743  C CB  . ASN   A 1 103 ? 6.36800   -6.19200  1.40400   1.000 51.28831 ? 299 ASN   A CB  1 
ATOM   744  C CG  . ASN   A 1 103 ? 5.49800   -4.97900  1.65300   1.000 58.08669 ? 299 ASN   A CG  1 
ATOM   745  O OD1 . ASN   A 1 103 ? 5.99700   -3.86200  1.79700   1.000 60.46961 ? 299 ASN   A OD1 1 
ATOM   746  N ND2 . ASN   A 1 103 ? 4.18800   -5.19400  1.72100   1.000 60.53976 ? 299 ASN   A ND2 1 
ATOM   747  N N   . LEU   A 1 104 ? 8.83400   -7.68200  -0.55600  1.000 45.70681 ? 300 LEU   A N   1 
ATOM   748  C CA  . LEU   A 1 104 ? 9.74100   -8.81500  -0.57900  1.000 48.61957 ? 300 LEU   A CA  1 
ATOM   749  C C   . LEU   A 1 104 ? 11.18800  -8.34100  -0.48500  1.000 49.18527 ? 300 LEU   A C   1 
ATOM   750  O O   . LEU   A 1 104 ? 11.51600  -7.19700  -0.81000  1.000 48.66292 ? 300 LEU   A O   1 
ATOM   751  C CB  . LEU   A 1 104 ? 9.54900   -9.62900  -1.86400  1.000 45.18115 ? 300 LEU   A CB  1 
ATOM   752  C CG  . LEU   A 1 104 ? 8.23300   -10.39000 -2.04700  1.000 50.51244 ? 300 LEU   A CG  1 
ATOM   753  C CD1 . LEU   A 1 104 ? 8.16600   -11.01100 -3.44100  1.000 41.98054 ? 300 LEU   A CD1 1 
ATOM   754  C CD2 . LEU   A 1 104 ? 8.03800   -11.45700 -0.97700  1.000 45.09191 ? 300 LEU   A CD2 1 
ATOM   755  N N   . ASP   A 1 105 ? 12.05900  -9.24500  -0.03600  1.000 45.36910 ? 301 ASP   A N   1 
ATOM   756  C CA  . ASP   A 1 105 ? 13.49300  -8.99500  -0.09800  1.000 49.10598 ? 301 ASP   A CA  1 
ATOM   757  C C   . ASP   A 1 105 ? 13.91800  -8.67400  -1.52700  1.000 50.78011 ? 301 ASP   A C   1 
ATOM   758  O O   . ASP   A 1 105 ? 13.41900  -9.26900  -2.48500  1.000 45.73386 ? 301 ASP   A O   1 
ATOM   759  C CB  . ASP   A 1 105 ? 14.26300  -10.21400 0.40900   1.000 52.32656 ? 301 ASP   A CB  1 
ATOM   760  C CG  . ASP   A 1 105 ? 15.74800  -9.94200  0.56900   1.000 56.07758 ? 301 ASP   A CG  1 
ATOM   761  O OD1 . ASP   A 1 105 ? 16.11600  -9.05100  1.36100   1.000 57.48470 ? 301 ASP   A OD1 1 
ATOM   762  O OD2 . ASP   A 1 105 ? 16.54800  -10.62100 -0.10900  1.000 56.68509 ? 301 ASP   A OD2 1 
ATOM   763  N N   . LEU   A 1 106 ? 14.85300  -7.72500  -1.65900  1.000 47.95365 ? 302 LEU   A N   1 
ATOM   764  C CA  . LEU   A 1 106 ? 15.35100  -7.33700  -2.97600  1.000 47.81522 ? 302 LEU   A CA  1 
ATOM   765  C C   . LEU   A 1 106 ? 15.88700  -8.53200  -3.75600  1.000 50.95541 ? 302 LEU   A C   1 
ATOM   766  O O   . LEU   A 1 106 ? 15.60700  -8.67600  -4.95200  1.000 49.37252 ? 302 LEU   A O   1 
ATOM   767  C CB  . LEU   A 1 106 ? 16.43900  -6.27300  -2.83300  1.000 49.82543 ? 302 LEU   A CB  1 
ATOM   768  C CG  . LEU   A 1 106 ? 16.97300  -5.64700  -4.12700  1.000 56.52246 ? 302 LEU   A CG  1 
ATOM   769  C CD1 . LEU   A 1 106 ? 15.84900  -5.05000  -4.96900  1.000 49.85393 ? 302 LEU   A CD1 1 
ATOM   770  C CD2 . LEU   A 1 106 ? 18.03700  -4.60500  -3.81500  1.000 52.06302 ? 302 LEU   A CD2 1 
ATOM   771  N N   . ASN   A 1 107 ? 16.67000  -9.39700  -3.10000  1.000 49.33872 ? 303 ASN   A N   1 
ATOM   772  C CA  . ASN   A 1 107 ? 17.21800  -10.55500 -3.80000  1.000 50.44560 ? 303 ASN   A CA  1 
ATOM   773  C C   . ASN   A 1 107 ? 16.11900  -11.51900 -4.22100  1.000 48.50905 ? 303 ASN   A C   1 
ATOM   774  O O   . ASN   A 1 107 ? 16.20900  -12.13700 -5.29100  1.000 46.23587 ? 303 ASN   A O   1 
ATOM   775  C CB  . ASN   A 1 107 ? 18.23900  -11.27400 -2.92200  1.000 56.36026 ? 303 ASN   A CB  1 
ATOM   776  C CG  . ASN   A 1 107 ? 19.39700  -10.38100 -2.52500  1.000 58.03582 ? 303 ASN   A CG  1 
ATOM   777  O OD1 . ASN   A 1 107 ? 19.87200  -9.56900  -3.31900  1.000 58.95404 ? 303 ASN   A OD1 1 
ATOM   778  N ND2 . ASN   A 1 107 ? 19.86400  -10.53300 -1.29100  1.000 55.14751 ? 303 ASN   A ND2 1 
ATOM   779  N N   . ASP   A 1 108 ? 15.08200  -11.66400 -3.39500  1.000 48.93025 ? 304 ASP   A N   1 
ATOM   780  C CA  . ASP   A 1 108 ? 13.94500  -12.48800 -3.78300  1.000 48.71217 ? 304 ASP   A CA  1 
ATOM   781  C C   . ASP   A 1 108 ? 13.18700  -11.85400 -4.94400  1.000 46.49113 ? 304 ASP   A C   1 
ATOM   782  O O   . ASP   A 1 108 ? 12.68200  -12.56200 -5.82300  1.000 43.30194 ? 304 ASP   A O   1 
ATOM   783  C CB  . ASP   A 1 108 ? 13.02800  -12.70800 -2.57900  1.000 46.34685 ? 304 ASP   A CB  1 
ATOM   784  C CG  . ASP   A 1 108 ? 13.38300  -13.96400 -1.79600  1.000 48.31587 ? 304 ASP   A CG  1 
ATOM   785  O OD1 . ASP   A 1 108 ? 14.32000  -14.68300 -2.20700  1.000 45.52082 ? 304 ASP   A OD1 1 
ATOM   786  O OD2 . ASP   A 1 108 ? 12.72500  -14.23200 -0.77100  1.000 45.95588 ? 304 ASP   A OD2 1 
ATOM   787  N N   . GLN   A 1 109 ? 13.10500  -10.52000 -4.96900  1.000 41.23286 ? 305 GLN   A N   1 
ATOM   788  C CA  . GLN   A 1 109 ? 12.49500  -9.84100  -6.10900  1.000 41.64958 ? 305 GLN   A CA  1 
ATOM   789  C C   . GLN   A 1 109 ? 13.28300  -10.10000 -7.38500  1.000 43.41035 ? 305 GLN   A C   1 
ATOM   790  O O   . GLN   A 1 109 ? 12.69600  -10.29200 -8.45700  1.000 40.23267 ? 305 GLN   A O   1 
ATOM   791  C CB  . GLN   A 1 109 ? 12.39900  -8.33600  -5.84300  1.000 42.88302 ? 305 GLN   A CB  1 
ATOM   792  C CG  . GLN   A 1 109 ? 11.45500  -7.94700  -4.71300  1.000 40.42639 ? 305 GLN   A CG  1 
ATOM   793  C CD  . GLN   A 1 109 ? 11.51600  -6.45900  -4.39600  1.000 46.37706 ? 305 GLN   A CD  1 
ATOM   794  O OE1 . GLN   A 1 109 ? 12.56800  -5.83200  -4.51600  1.000 46.98700 ? 305 GLN   A OE1 1 
ATOM   795  N NE2 . GLN   A 1 109 ? 10.39200  -5.89500  -3.96600  1.000 43.16676 ? 305 GLN   A NE2 1 
ATOM   796  N N   . VAL   A 1 110 ? 14.61700  -10.10600 -7.29200  1.000 43.46299 ? 306 VAL   A N   1 
ATOM   797  C CA  . VAL   A 1 110 ? 15.44600  -10.39700 -8.46000  1.000 44.69265 ? 306 VAL   A CA  1 
ATOM   798  C C   . VAL   A 1 110 ? 15.20000  -11.82300 -8.94000  1.000 45.02943 ? 306 VAL   A C   1 
ATOM   799  O O   . VAL   A 1 110 ? 15.06500  -12.07800 -10.14400 1.000 43.04026 ? 306 VAL   A O   1 
ATOM   800  C CB  . VAL   A 1 110 ? 16.93300  -10.16000 -8.13800  1.000 44.79699 ? 306 VAL   A CB  1 
ATOM   801  C CG1 . VAL   A 1 110 ? 17.80700  -10.60400 -9.30600  1.000 43.70277 ? 306 VAL   A CG1 1 
ATOM   802  C CG2 . VAL   A 1 110 ? 17.18100  -8.69900  -7.80400  1.000 44.52826 ? 306 VAL   A CG2 1 
ATOM   803  N N   . THR   A 1 111 ? 15.13000  -12.77100 -8.00000  1.000 42.12407 ? 307 THR   A N   1 
ATOM   804  C CA  . THR   A 1 111 ? 14.90300  -14.16900 -8.35700  1.000 43.94551 ? 307 THR   A CA  1 
ATOM   805  C C   . THR   A 1 111 ? 13.58300  -14.35000 -9.09900  1.000 42.22617 ? 307 THR   A C   1 
ATOM   806  O O   . THR   A 1 111 ? 13.52100  -15.06000 -10.10900 1.000 41.50464 ? 307 THR   A O   1 
ATOM   807  C CB  . THR   A 1 111 ? 14.93000  -15.03900 -7.09800  1.000 47.47042 ? 307 THR   A CB  1 
ATOM   808  O OG1 . THR   A 1 111 ? 16.21200  -14.93400 -6.46800  1.000 52.38637 ? 307 THR   A OG1 1 
ATOM   809  C CG2 . THR   A 1 111 ? 14.66100  -16.49900 -7.44400  1.000 44.22278 ? 307 THR   A CG2 1 
ATOM   810  N N   . LEU   A 1 112 ? 12.51000  -13.72000 -8.60600  1.000 41.00579 ? 308 LEU   A N   1 
ATOM   811  C CA  . LEU   A 1 112 ? 11.19900  -13.90300 -9.22400  1.000 39.42929 ? 308 LEU   A CA  1 
ATOM   812  C C   . LEU   A 1 112 ? 11.17800  -13.37500 -10.65200 1.000 39.97027 ? 308 LEU   A C   1 
ATOM   813  O O   . LEU   A 1 112 ? 10.59400  -14.00100 -11.54500 1.000 39.53701 ? 308 LEU   A O   1 
ATOM   814  C CB  . LEU   A 1 112 ? 10.11500  -13.22000 -8.39200  1.000 39.36849 ? 308 LEU   A CB  1 
ATOM   815  C CG  . LEU   A 1 112 ? 9.78400   -13.84000 -7.03300  1.000 42.49166 ? 308 LEU   A CG  1 
ATOM   816  C CD1 . LEU   A 1 112 ? 8.52300   -13.21400 -6.46000  1.000 38.89966 ? 308 LEU   A CD1 1 
ATOM   817  C CD2 . LEU   A 1 112 ? 9.63100   -15.34900 -7.13800  1.000 42.33871 ? 308 LEU   A CD2 1 
ATOM   818  N N   . LEU   A 1 113 ? 11.80700  -12.22400 -10.88800 1.000 39.70235 ? 309 LEU   A N   1 
ATOM   819  C CA  . LEU   A 1 113 ? 11.83800  -11.66700 -12.23500 1.000 42.10926 ? 309 LEU   A CA  1 
ATOM   820  C C   . LEU   A 1 113 ? 12.72400  -12.50100 -13.15100 1.000 42.33974 ? 309 LEU   A C   1 
ATOM   821  O O   . LEU   A 1 113 ? 12.30900  -12.87200 -14.25500 1.000 38.83423 ? 309 LEU   A O   1 
ATOM   822  C CB  . LEU   A 1 113 ? 12.31300  -10.21300 -12.19200 1.000 40.51796 ? 309 LEU   A CB  1 
ATOM   823  C CG  . LEU   A 1 113 ? 11.32800  -9.20700  -11.59100 1.000 40.93464 ? 309 LEU   A CG  1 
ATOM   824  C CD1 . LEU   A 1 113 ? 12.02100  -7.88400  -11.29100 1.000 42.27835 ? 309 LEU   A CD1 1 
ATOM   825  C CD2 . LEU   A 1 113 ? 10.13600  -9.00200  -12.52600 1.000 43.01404 ? 309 LEU   A CD2 1 
ATOM   826  N N   . LYS   A 1 114 ? 13.94100  -12.82100 -12.69500 1.000 43.21469 ? 310 LYS   A N   1 
ATOM   827  C CA  . LYS   A 1 114 ? 14.89000  -13.59800 -13.49300 1.000 46.60174 ? 310 LYS   A CA  1 
ATOM   828  C C   . LYS   A 1 114 ? 14.24200  -14.83500 -14.10000 1.000 43.52921 ? 310 LYS   A C   1 
ATOM   829  O O   . LYS   A 1 114 ? 14.32500  -15.06800 -15.31000 1.000 45.13344 ? 310 LYS   A O   1 
ATOM   830  C CB  . LYS   A 1 114 ? 16.08400  -14.00200 -12.62300 1.000 49.21805 ? 310 LYS   A CB  1 
ATOM   831  C CG  . LYS   A 1 114 ? 17.06700  -14.97000 -13.28500 1.000 50.85373 ? 310 LYS   A CG  1 
ATOM   832  C CD  . LYS   A 1 114 ? 18.14400  -15.40400 -12.28900 1.000 55.65576 ? 310 LYS   A CD  1 
ATOM   833  C CE  . LYS   A 1 114 ? 19.54200  -15.39000 -12.89400 1.000 60.86563 ? 310 LYS   A CE  1 
ATOM   834  N NZ  . LYS   A 1 114 ? 19.59800  -16.01900 -14.24400 1.000 66.98030 ? 310 LYS   A NZ  1 
ATOM   835  N N   . TYR   A 1 115 ? 13.58600  -15.64300 -13.27200 1.000 43.67388 ? 311 TYR   A N   1 
ATOM   836  C CA  . TYR   A 1 115 ? 12.98200  -16.87200 -13.76600 1.000 43.28489 ? 311 TYR   A CA  1 
ATOM   837  C C   . TYR   A 1 115 ? 11.59900  -16.65900 -14.36300 1.000 44.59023 ? 311 TYR   A C   1 
ATOM   838  O O   . TYR   A 1 115 ? 11.12300  -17.52600 -15.10300 1.000 45.85985 ? 311 TYR   A O   1 
ATOM   839  C CB  . TYR   A 1 115 ? 12.92200  -17.90200 -12.63800 1.000 48.99140 ? 311 TYR   A CB  1 
ATOM   840  C CG  . TYR   A 1 115 ? 14.29400  -18.33000 -12.16600 1.000 49.53032 ? 311 TYR   A CG  1 
ATOM   841  C CD1 . TYR   A 1 115 ? 14.98300  -19.34800 -12.81500 1.000 59.53798 ? 311 TYR   A CD1 1 
ATOM   842  C CD2 . TYR   A 1 115 ? 14.91000  -17.70400 -11.09200 1.000 53.54896 ? 311 TYR   A CD2 1 
ATOM   843  C CE1 . TYR   A 1 115 ? 16.24200  -19.74200 -12.39600 1.000 61.58382 ? 311 TYR   A CE1 1 
ATOM   844  C CE2 . TYR   A 1 115 ? 16.17200  -18.09000 -10.66500 1.000 56.86202 ? 311 TYR   A CE2 1 
ATOM   845  C CZ  . TYR   A 1 115 ? 16.83200  -19.10800 -11.32100 1.000 62.92193 ? 311 TYR   A CZ  1 
ATOM   846  O OH  . TYR   A 1 115 ? 18.08500  -19.49600 -10.89900 1.000 68.00193 ? 311 TYR   A OH  1 
ATOM   847  N N   . GLY   A 1 116 ? 10.96000  -15.52300 -14.09200 1.000 41.02829 ? 312 GLY   A N   1 
ATOM   848  C CA  . GLY   A 1 116 ? 9.58700   -15.31700 -14.50800 1.000 38.94991 ? 312 GLY   A CA  1 
ATOM   849  C C   . GLY   A 1 116 ? 9.36400   -14.52900 -15.78700 1.000 35.21341 ? 312 GLY   A C   1 
ATOM   850  O O   . GLY   A 1 116 ? 8.34600   -14.73000 -16.45700 1.000 37.07568 ? 312 GLY   A O   1 
ATOM   851  N N   . VAL   A 1 117 ? 10.29500  -13.63900 -16.14800 1.000 37.52091 ? 313 VAL   A N   1 
ATOM   852  C CA  . VAL   A 1 117 ? 10.00800  -12.66300 -17.20000 1.000 37.65789 ? 313 VAL   A CA  1 
ATOM   853  C C   . VAL   A 1 117 ? 9.76100   -13.35000 -18.53700 1.000 38.49027 ? 313 VAL   A C   1 
ATOM   854  O O   . VAL   A 1 117 ? 8.88000   -12.94300 -19.30600 1.000 36.59650 ? 313 VAL   A O   1 
ATOM   855  C CB  . VAL   A 1 117 ? 11.13800  -11.61900 -17.30600 1.000 39.32365 ? 313 VAL   A CB  1 
ATOM   856  C CG1 . VAL   A 1 117 ? 11.04900  -10.62700 -16.15600 1.000 39.32084 ? 313 VAL   A CG1 1 
ATOM   857  C CG2 . VAL   A 1 117 ? 12.50700  -12.28900 -17.35400 1.000 41.43736 ? 313 VAL   A CG2 1 
ATOM   858  N N   . TYR   A 1 118 ? 10.52200  -14.40100 -18.84200 1.000 38.23860 ? 314 TYR   A N   1 
ATOM   859  C CA  . TYR   A 1 118 ? 10.38800  -14.98000 -20.17300 1.000 37.21398 ? 314 TYR   A CA  1 
ATOM   860  C C   . TYR   A 1 118 ? 9.16200   -15.87100 -20.28800 1.000 35.53868 ? 314 TYR   A C   1 
ATOM   861  O O   . TYR   A 1 118 ? 8.57500   -15.96400 -21.37000 1.000 36.28391 ? 314 TYR   A O   1 
ATOM   862  C CB  . TYR   A 1 118 ? 11.66700  -15.72000 -20.56200 1.000 41.22026 ? 314 TYR   A CB  1 
ATOM   863  C CG  . TYR   A 1 118 ? 12.65200  -14.76900 -21.19900 1.000 43.99543 ? 314 TYR   A CG  1 
ATOM   864  C CD1 . TYR   A 1 118 ? 12.47100  -14.33400 -22.50500 1.000 40.15224 ? 314 TYR   A CD1 1 
ATOM   865  C CD2 . TYR   A 1 118 ? 13.72600  -14.25800 -20.47800 1.000 44.20872 ? 314 TYR   A CD2 1 
ATOM   866  C CE1 . TYR   A 1 118 ? 13.35000  -13.44100 -23.09100 1.000 43.74683 ? 314 TYR   A CE1 1 
ATOM   867  C CE2 . TYR   A 1 118 ? 14.61400  -13.36400 -21.05800 1.000 43.46658 ? 314 TYR   A CE2 1 
ATOM   868  C CZ  . TYR   A 1 118 ? 14.42000  -12.96200 -22.36500 1.000 41.91447 ? 314 TYR   A CZ  1 
ATOM   869  O OH  . TYR   A 1 118 ? 15.29200  -12.07400 -22.95200 1.000 47.87431 ? 314 TYR   A OH  1 
ATOM   870  N N   . GLU   A 1 119 ? 8.73100   -16.49900 -19.19400 1.000 35.14300 ? 315 GLU   A N   1 
ATOM   871  C CA  . GLU   A 1 119 ? 7.43000   -17.15700 -19.22900 1.000 38.58975 ? 315 GLU   A CA  1 
ATOM   872  C C   . GLU   A 1 119 ? 6.32100   -16.14600 -19.48800 1.000 33.87387 ? 315 GLU   A C   1 
ATOM   873  O O   . GLU   A 1 119 ? 5.39700   -16.41300 -20.26500 1.000 32.91441 ? 315 GLU   A O   1 
ATOM   874  C CB  . GLU   A 1 119 ? 7.17400   -17.91400 -17.92900 1.000 36.19646 ? 315 GLU   A CB  1 
ATOM   875  C CG  . GLU   A 1 119 ? 8.07700   -19.12100 -17.72100 1.000 41.74400 ? 315 GLU   A CG  1 
ATOM   876  C CD  . GLU   A 1 119 ? 7.94200   -19.69800 -16.32700 1.000 43.48727 ? 315 GLU   A CD  1 
ATOM   877  O OE1 . GLU   A 1 119 ? 8.86200   -20.42200 -15.89000 1.000 43.99866 ? 315 GLU   A OE1 1 
ATOM   878  O OE2 . GLU   A 1 119 ? 6.91300   -19.42700 -15.66600 1.000 41.13639 ? 315 GLU   A OE2 1 
ATOM   879  N N   . ALA   A 1 120 ? 6.40800   -14.97000 -18.85500 1.000 32.92749 ? 316 ALA   A N   1 
ATOM   880  C CA  . ALA   A 1 120 ? 5.41400   -13.92500 -19.08200 1.000 34.80550 ? 316 ALA   A CA  1 
ATOM   881  C C   . ALA   A 1 120 ? 5.52000   -13.34600 -20.48700 1.000 29.79759 ? 316 ALA   A C   1 
ATOM   882  O O   . ALA   A 1 120 ? 4.50000   -13.06600 -21.12500 1.000 30.70175 ? 316 ALA   A O   1 
ATOM   883  C CB  . ALA   A 1 120 ? 5.56400   -12.81700 -18.03200 1.000 35.77849 ? 316 ALA   A CB  1 
ATOM   884  N N   . ILE   A 1 121 ? 6.74400   -13.14700 -20.98400 1.000 32.76803 ? 317 ILE   A N   1 
ATOM   885  C CA  . ILE   A 1 121 ? 6.92000   -12.58100 -22.32100 1.000 32.88978 ? 317 ILE   A CA  1 
ATOM   886  C C   . ILE   A 1 121 ? 6.26200   -13.47100 -23.37100 1.000 32.68066 ? 317 ILE   A C   1 
ATOM   887  O O   . ILE   A 1 121 ? 5.51000   -12.99500 -24.22900 1.000 28.40734 ? 317 ILE   A O   1 
ATOM   888  C CB  . ILE   A 1 121 ? 8.41400   -12.35900 -22.62700 1.000 37.80414 ? 317 ILE   A CB  1 
ATOM   889  C CG1 . ILE   A 1 121 ? 8.90800   -11.06500 -21.97900 1.000 36.80096 ? 317 ILE   A CG1 1 
ATOM   890  C CG2 . ILE   A 1 121 ? 8.65500   -12.32900 -24.13600 1.000 34.52976 ? 317 ILE   A CG2 1 
ATOM   891  C CD1 . ILE   A 1 121 ? 10.41000  -10.89800 -22.03000 1.000 42.66382 ? 317 ILE   A CD1 1 
ATOM   892  N N   . PHE   A 1 122 ? 6.52600   -14.78200 -23.31200 1.000 32.46986 ? 318 PHE   A N   1 
ATOM   893  C CA  . PHE   A 1 122 ? 5.98100   -15.67800 -24.32900 1.000 30.31779 ? 318 PHE   A CA  1 
ATOM   894  C C   . PHE   A 1 122 ? 4.48500   -15.89700 -24.15300 1.000 31.57416 ? 318 PHE   A C   1 
ATOM   895  O O   . PHE   A 1 122 ? 3.77400   -16.07200 -25.14700 1.000 32.23228 ? 318 PHE   A O   1 
ATOM   896  C CB  . PHE   A 1 122 ? 6.74200   -17.00700 -24.32200 1.000 36.73664 ? 318 PHE   A CB  1 
ATOM   897  C CG  . PHE   A 1 122 ? 8.18700   -16.85800 -24.69900 1.000 37.79794 ? 318 PHE   A CG  1 
ATOM   898  C CD1 . PHE   A 1 122 ? 8.54800   -16.01200 -25.73800 1.000 36.44915 ? 318 PHE   A CD1 1 
ATOM   899  C CD2 . PHE   A 1 122 ? 9.18300   -17.51800 -24.00000 1.000 38.09979 ? 318 PHE   A CD2 1 
ATOM   900  C CE1 . PHE   A 1 122 ? 9.87300   -15.84400 -26.09000 1.000 37.58550 ? 318 PHE   A CE1 1 
ATOM   901  C CE2 . PHE   A 1 122 ? 10.51400  -17.35300 -24.34700 1.000 40.63618 ? 318 PHE   A CE2 1 
ATOM   902  C CZ  . PHE   A 1 122 ? 10.85800  -16.51300 -25.39400 1.000 39.98785 ? 318 PHE   A CZ  1 
ATOM   903  N N   . ALA   A 1 123 ? 3.98400   -15.88800 -22.91100 1.000 30.03497 ? 319 ALA   A N   1 
ATOM   904  C CA  . ALA   A 1 123 ? 2.53800   -15.83200 -22.71600 1.000 29.78927 ? 319 ALA   A CA  1 
ATOM   905  C C   . ALA   A 1 123 ? 1.95000   -14.61300 -23.42200 1.000 36.23952 ? 319 ALA   A C   1 
ATOM   906  O O   . ALA   A 1 123 ? 1.01800   -14.72500 -24.23100 1.000 31.12061 ? 319 ALA   A O   1 
ATOM   907  C CB  . ALA   A 1 123 ? 2.20900   -15.79800 -21.22300 1.000 32.76379 ? 319 ALA   A CB  1 
ATOM   908  N N   . MET   A 1 124 ? 2.51900   -13.43900 -23.14100 1.000 28.01973 ? 320 MET   A N   1 
ATOM   909  C CA  . MET   A 1 124 ? 2.00300   -12.17400 -23.64600 1.000 28.64062 ? 320 MET   A CA  1 
ATOM   910  C C   . MET   A 1 124 ? 2.26100   -12.02500 -25.14200 1.000 33.08333 ? 320 MET   A C   1 
ATOM   911  O O   . MET   A 1 124 ? 1.48200   -11.37200 -25.85100 1.000 31.55096 ? 320 MET   A O   1 
ATOM   912  C CB  . MET   A 1 124 ? 2.69100   -11.06400 -22.85700 1.000 34.34213 ? 320 MET   A CB  1 
ATOM   913  C CG  . MET   A 1 124 ? 2.14700   -10.92900 -21.44500 1.000 34.49084 ? 320 MET   A CG  1 
ATOM   914  S SD  . MET   A 1 124 ? 2.33800   -9.28000  -20.76700 1.000 35.41652 ? 320 MET   A SD  1 
ATOM   915  C CE  . MET   A 1 124 ? 4.04000   -9.40600  -20.25400 1.000 36.47226 ? 320 MET   A CE  1 
ATOM   916  N N   . LEU   A 1 125 ? 3.35200   -12.62400 -25.63100 1.000 32.22555 ? 321 LEU   A N   1 
ATOM   917  C CA  . LEU   A 1 125 ? 3.63900   -12.65500 -27.06200 1.000 34.49981 ? 321 LEU   A CA  1 
ATOM   918  C C   . LEU   A 1 125 ? 2.47500   -13.21800 -27.86600 1.000 32.82206 ? 321 LEU   A C   1 
ATOM   919  O O   . LEU   A 1 125 ? 2.25600   -12.81600 -29.01600 1.000 33.20689 ? 321 LEU   A O   1 
ATOM   920  C CB  . LEU   A 1 125 ? 4.89800   -13.48600 -27.29700 1.000 30.27013 ? 321 LEU   A CB  1 
ATOM   921  C CG  . LEU   A 1 125 ? 5.44700   -13.60100 -28.71900 1.000 36.16138 ? 321 LEU   A CG  1 
ATOM   922  C CD1 . LEU   A 1 125 ? 5.84000   -12.24600 -29.26500 1.000 36.96897 ? 321 LEU   A CD1 1 
ATOM   923  C CD2 . LEU   A 1 125 ? 6.63200   -14.55100 -28.70600 1.000 34.00257 ? 321 LEU   A CD2 1 
ATOM   924  N N   . SER   A 1 126 ? 1.71400   -14.13900 -27.27300 1.000 31.26320 ? 322 SER   A N   1 
ATOM   925  C CA  . SER   A 1 126 ? 0.58800   -14.74200 -27.97200 1.000 34.21114 ? 322 SER   A CA  1 
ATOM   926  C C   . SER   A 1 126 ? -0.42800  -13.70000 -28.41200 1.000 36.32446 ? 322 SER   A C   1 
ATOM   927  O O   . SER   A 1 126 ? -1.06100  -13.85800 -29.46200 1.000 34.12035 ? 322 SER   A O   1 
ATOM   928  C CB  . SER   A 1 126 ? -0.07600  -15.77800 -27.07000 1.000 35.01620 ? 322 SER   A CB  1 
ATOM   929  O OG  . SER   A 1 126 ? 0.87100   -16.73900 -26.63800 1.000 32.87784 ? 322 SER   A OG  1 
ATOM   930  N N   . SER   A 1 127 ? -0.57400  -12.61900 -27.63600 1.000 34.87419 ? 323 SER   A N   1 
ATOM   931  C CA  . SER   A 1 127 ? -1.59600  -11.61700 -27.91600 1.000 35.26297 ? 323 SER   A CA  1 
ATOM   932  C C   . SER   A 1 127 ? -1.33000  -10.88200 -29.22500 1.000 34.51745 ? 323 SER   A C   1 
ATOM   933  O O   . SER   A 1 127 ? -2.27400  -10.41200 -29.87200 1.000 35.41852 ? 323 SER   A O   1 
ATOM   934  C CB  . SER   A 1 127 ? -1.67900  -10.61400 -26.76000 1.000 31.71416 ? 323 SER   A CB  1 
ATOM   935  O OG  . SER   A 1 127 ? -2.11200  -11.22800 -25.55600 1.000 34.02738 ? 323 SER   A OG  1 
ATOM   936  N N   . VAL   A 1 128 ? -0.07200  -10.77100 -29.59900 1.000 30.37073 ? 324 VAL   A N   1 
ATOM   937  C CA  . VAL   A 1 128 ? 0.27500   -10.08200 -30.80200 1.000 32.23198 ? 324 VAL   A CA  1 
ATOM   938  C C   . VAL   A 1 128 ? 0.53500   -11.01300 -31.97300 1.000 41.04573 ? 324 VAL   A C   1 
ATOM   939  O O   . VAL   A 1 128 ? 1.08700   -10.61400 -32.97200 1.000 38.05332 ? 324 VAL   A O   1 
ATOM   940  C CB  . VAL   A 1 128 ? 1.47400   -9.17200  -30.58900 1.000 35.70513 ? 324 VAL   A CB  1 
ATOM   941  C CG1 . VAL   A 1 128 ? 1.18600   -8.19300  -29.48800 1.000 40.73295 ? 324 VAL   A CG1 1 
ATOM   942  C CG2 . VAL   A 1 128 ? 2.71000   -9.95800  -30.29600 1.000 36.60417 ? 324 VAL   A CG2 1 
ATOM   943  N N   . MET   A 1 129 ? 0.08100   -12.24600 -31.83100 1.000 34.42286 ? 325 MET   A N   1 
ATOM   944  C CA  . MET   A 1 129 ? 0.27100   -13.26800 -32.82100 1.000 37.88429 ? 325 MET   A CA  1 
ATOM   945  C C   . MET   A 1 129 ? -0.99600  -13.83200 -33.40300 1.000 42.36718 ? 325 MET   A C   1 
ATOM   946  O O   . MET   A 1 129 ? -1.98700  -13.98200 -32.74300 1.000 40.62324 ? 325 MET   A O   1 
ATOM   947  C CB  . MET   A 1 129 ? 0.98500   -14.44800 -32.19300 1.000 35.11962 ? 325 MET   A CB  1 
ATOM   948  C CG  . MET   A 1 129 ? 2.48500   -14.38400 -32.19700 1.000 37.54541 ? 325 MET   A CG  1 
ATOM   949  S SD  . MET   A 1 129 ? 3.26400   -15.82600 -31.50800 1.000 35.09761 ? 325 MET   A SD  1 
ATOM   950  C CE  . MET   A 1 129 ? 4.93200   -15.50700 -31.92800 1.000 36.64290 ? 325 MET   A CE  1 
ATOM   951  N N   . ASN   A 1 130 ? -0.94800  -14.08300 -34.68500 1.000 43.55932 ? 326 ASN   A N   1 
ATOM   952  C CA  . ASN   A 1 130 ? -2.00300  -14.82200 -35.33500 1.000 44.67534 ? 326 ASN   A CA  1 
ATOM   953  C C   . ASN   A 1 130 ? -1.34700  -15.96500 -36.10400 1.000 43.45340 ? 326 ASN   A C   1 
ATOM   954  O O   . ASN   A 1 130 ? -0.14600  -16.13900 -36.07400 1.000 43.97428 ? 326 ASN   A O   1 
ATOM   955  C CB  . ASN   A 1 130 ? -2.95100  -13.96700 -36.16400 1.000 44.23781 ? 326 ASN   A CB  1 
ATOM   956  C CG  . ASN   A 1 130 ? -2.36700  -13.49700 -37.46300 1.000 41.80570 ? 326 ASN   A CG  1 
ATOM   957  O OD1 . ASN   A 1 130 ? -1.33900  -13.92000 -37.89200 1.000 40.51680 ? 326 ASN   A OD1 1 
ATOM   958  N ND2 . ASN   A 1 130 ? -3.06000  -12.60900 -38.08600 1.000 47.96834 ? 326 ASN   A ND2 1 
ATOM   959  N N   . LYS   A 1 131 ? -2.12900  -16.75700 -36.80400 1.000 47.38290 ? 327 LYS   A N   1 
ATOM   960  C CA  . LYS   A 1 131 ? -1.56300  -17.88100 -37.53500 1.000 47.60185 ? 327 LYS   A CA  1 
ATOM   961  C C   . LYS   A 1 131 ? -0.53300  -17.51700 -38.59000 1.000 48.92322 ? 327 LYS   A C   1 
ATOM   962  O O   . LYS   A 1 131 ? 0.34100   -18.29700 -38.85200 1.000 44.74436 ? 327 LYS   A O   1 
ATOM   963  C CB  . LYS   A 1 131 ? -2.64800  -18.75900 -38.14800 1.000 49.14619 ? 327 LYS   A CB  1 
ATOM   964  C CG  . LYS   A 1 131 ? -3.67000  -18.01200 -38.98300 1.000 53.28629 ? 327 LYS   A CG  1 
ATOM   965  C CD  . LYS   A 1 131 ? -4.31500  -18.90800 -40.02800 1.000 62.67579 ? 327 LYS   A CD  1 
ATOM   966  C CE  . LYS   A 1 131 ? -4.47400  -18.18400 -41.36100 1.000 62.65193 ? 327 LYS   A CE  1 
ATOM   967  N NZ  . LYS   A 1 131 ? -3.61300  -18.72900 -42.45000 1.000 63.57806 ? 327 LYS   A NZ  1 
ATOM   968  N N   . ASP   A 1 132 ? -0.62200  -16.32200 -39.14800 1.000 41.75793 ? 328 ASP   A N   1 
ATOM   969  C CA  . ASP   A 1 132 ? 0.29900   -15.89500 -40.18800 1.000 43.93897 ? 328 ASP   A CA  1 
ATOM   970  C C   . ASP   A 1 132 ? 1.49800   -15.01000 -39.81900 1.000 48.18993 ? 328 ASP   A C   1 
ATOM   971  O O   . ASP   A 1 132 ? 2.37400   -14.84100 -40.62200 1.000 43.15249 ? 328 ASP   A O   1 
ATOM   972  C CB  . ASP   A 1 132 ? -0.47300  -15.21000 -41.30600 1.000 51.28528 ? 328 ASP   A CB  1 
ATOM   973  C CG  . ASP   A 1 132 ? -1.63300  -16.01900 -41.80400 1.000 51.54883 ? 328 ASP   A CG  1 
ATOM   974  O OD1 . ASP   A 1 132 ? -1.48100  -17.21100 -42.03700 1.000 50.23403 ? 328 ASP   A OD1 1 
ATOM   975  O OD2 . ASP   A 1 132 ? -2.69800  -15.44800 -41.97500 1.000 53.64096 ? 328 ASP   A OD2 1 
ATOM   976  N N   . GLY   A 1 133 ? 1.53100   -14.43900 -38.62900 1.000 40.02502 ? 329 GLY   A N   1 
ATOM   977  C CA  . GLY   A 1 133 ? 2.63700   -13.60100 -38.22500 1.000 36.69139 ? 329 GLY   A CA  1 
ATOM   978  C C   . GLY   A 1 133 ? 2.46400   -12.91800 -36.88400 1.000 39.47319 ? 329 GLY   A C   1 
ATOM   979  O O   . GLY   A 1 133 ? 1.57300   -13.26000 -36.15200 1.000 34.24484 ? 329 GLY   A O   1 
ATOM   980  N N   . MET   A 1 134 ? 3.32300   -11.95100 -36.57900 1.000 41.68093 ? 330 MET   A N   1 
ATOM   981  C CA  . MET   A 1 134 ? 3.24800   -11.23500 -35.30800 1.000 35.32562 ? 330 MET   A CA  1 
ATOM   982  C C   . MET   A 1 134 ? 3.45900   -9.74100  -35.51800 1.000 39.07624 ? 330 MET   A C   1 
ATOM   983  O O   . MET   A 1 134 ? 4.17300   -9.31500  -36.43300 1.000 38.00411 ? 330 MET   A O   1 
ATOM   984  C CB  . MET   A 1 134 ? 4.29700   -11.69600 -34.29400 1.000 36.22839 ? 330 MET   A CB  1 
ATOM   985  C CG  . MET   A 1 134 ? 5.71600   -11.58800 -34.79600 1.000 39.47634 ? 330 MET   A CG  1 
ATOM   986  S SD  . MET   A 1 134 ? 6.91100   -12.49600 -33.81600 1.000 47.21227 ? 330 MET   A SD  1 
ATOM   987  C CE  . MET   A 1 134 ? 7.39500   -11.24700 -32.62800 1.000 46.29610 ? 330 MET   A CE  1 
ATOM   988  N N   . LEU   A 1 135 ? 2.85900   -8.95400  -34.62500 1.000 34.74463 ? 331 LEU   A N   1 
ATOM   989  C CA  . LEU   A 1 135 ? 3.06100   -7.51100  -34.62400 1.000 39.49230 ? 331 LEU   A CA  1 
ATOM   990  C C   . LEU   A 1 135 ? 4.43700   -7.16000  -34.07600 1.000 39.27322 ? 331 LEU   A C   1 
ATOM   991  O O   . LEU   A 1 135 ? 4.93000   -7.79500  -33.14000 1.000 39.84333 ? 331 LEU   A O   1 
ATOM   992  C CB  . LEU   A 1 135 ? 1.98400   -6.82700  -33.78000 1.000 37.97109 ? 331 LEU   A CB  1 
ATOM   993  C CG  . LEU   A 1 135 ? 0.55300   -6.93300  -34.30100 1.000 39.40890 ? 331 LEU   A CG  1 
ATOM   994  C CD1 . LEU   A 1 135 ? -0.41100  -6.26100  -33.34200 1.000 38.92267 ? 331 LEU   A CD1 1 
ATOM   995  C CD2 . LEU   A 1 135 ? 0.46200   -6.31000  -35.68200 1.000 44.58024 ? 331 LEU   A CD2 1 
ATOM   996  N N   . VAL   A 1 136 ? 5.05300   -6.13000  -34.66100 1.000 39.92140 ? 332 VAL   A N   1 
ATOM   997  C CA  . VAL   A 1 136 ? 6.31800   -5.57900  -34.19000 1.000 38.51123 ? 332 VAL   A CA  1 
ATOM   998  C C   . VAL   A 1 136 ? 6.26700   -4.05900  -34.30400 1.000 37.23560 ? 332 VAL   A C   1 
ATOM   999  O O   . VAL   A 1 136 ? 5.33900   -3.48700  -34.87900 1.000 36.41869 ? 332 VAL   A O   1 
ATOM   1000 C CB  . VAL   A 1 136 ? 7.52800   -6.12800  -34.97400 1.000 39.79019 ? 332 VAL   A CB  1 
ATOM   1001 C CG1 . VAL   A 1 136 ? 7.68000   -7.62900  -34.74600 1.000 42.38593 ? 332 VAL   A CG1 1 
ATOM   1002 C CG2 . VAL   A 1 136 ? 7.38200   -5.80100  -36.46000 1.000 40.64260 ? 332 VAL   A CG2 1 
ATOM   1003 N N   . ALA   A 1 137 ? 7.28800   -3.41000  -33.74100 1.000 38.92342 ? 333 ALA   A N   1 
ATOM   1004 C CA  . ALA   A 1 137 ? 7.44800   -1.95400  -33.81100 1.000 43.17219 ? 333 ALA   A CA  1 
ATOM   1005 C C   . ALA   A 1 137 ? 6.20500   -1.23300  -33.29700 1.000 37.08454 ? 333 ALA   A C   1 
ATOM   1006 O O   . ALA   A 1 137 ? 5.64600   -0.35400  -33.95800 1.000 38.83156 ? 333 ALA   A O   1 
ATOM   1007 C CB  . ALA   A 1 137 ? 7.78800   -1.50600  -35.23600 1.000 42.42768 ? 333 ALA   A CB  1 
ATOM   1008 N N   . TYR   A 1 138 ? 5.76900   -1.63300  -32.09900 1.000 37.07792 ? 334 TYR   A N   1 
ATOM   1009 C CA  . TYR   A 1 138 ? 4.64100   -1.01200  -31.39800 1.000 39.20368 ? 334 TYR   A CA  1 
ATOM   1010 C C   . TYR   A 1 138 ? 3.37000   -1.03000  -32.24400 1.000 42.16270 ? 334 TYR   A C   1 
ATOM   1011 O O   . TYR   A 1 138 ? 2.60200   -0.06500  -32.26500 1.000 42.00233 ? 334 TYR   A O   1 
ATOM   1012 C CB  . TYR   A 1 138 ? 4.97900   0.41000   -30.94700 1.000 39.09875 ? 334 TYR   A CB  1 
ATOM   1013 C CG  . TYR   A 1 138 ? 6.21400   0.45300   -30.07900 1.000 44.62698 ? 334 TYR   A CG  1 
ATOM   1014 C CD1 . TYR   A 1 138 ? 6.11200   0.47500   -28.69700 1.000 40.21747 ? 334 TYR   A CD1 1 
ATOM   1015 C CD2 . TYR   A 1 138 ? 7.48200   0.50300   -30.64400 1.000 45.06572 ? 334 TYR   A CD2 1 
ATOM   1016 C CE1 . TYR   A 1 138 ? 7.23800   0.50600   -27.90000 1.000 47.28282 ? 334 TYR   A CE1 1 
ATOM   1017 C CE2 . TYR   A 1 138 ? 8.61300   0.54500   -29.85700 1.000 47.22953 ? 334 TYR   A CE2 1 
ATOM   1018 C CZ  . TYR   A 1 138 ? 8.48500   0.54700   -28.48500 1.000 47.92955 ? 334 TYR   A CZ  1 
ATOM   1019 O OH  . TYR   A 1 138 ? 9.61200   0.58700   -27.69600 1.000 55.57486 ? 334 TYR   A OH  1 
ATOM   1020 N N   . GLY   A 1 139 ? 3.14700   -2.14100  -32.94500 1.000 36.73624 ? 335 GLY   A N   1 
ATOM   1021 C CA  . GLY   A 1 139 ? 1.95200   -2.32800  -33.73800 1.000 34.05621 ? 335 GLY   A CA  1 
ATOM   1022 C C   . GLY   A 1 139 ? 2.00100   -1.76900  -35.14400 1.000 40.06422 ? 335 GLY   A C   1 
ATOM   1023 O O   . GLY   A 1 139 ? 1.00200   -1.88100  -35.86600 1.000 40.40125 ? 335 GLY   A O   1 
ATOM   1024 N N   . ASN   A 1 140 ? 3.12200   -1.17600  -35.56300 1.000 39.52751 ? 336 ASN   A N   1 
ATOM   1025 C CA  . ASN   A 1 140 ? 3.23300   -0.59900  -36.89800 1.000 40.23655 ? 336 ASN   A CA  1 
ATOM   1026 C C   . ASN   A 1 140 ? 3.86200   -1.54400  -37.91500 1.000 47.01582 ? 336 ASN   A C   1 
ATOM   1027 O O   . ASN   A 1 140 ? 3.92100   -1.20100  -39.10200 1.000 48.26807 ? 336 ASN   A O   1 
ATOM   1028 C CB  . ASN   A 1 140 ? 4.04100   0.69900   -36.84500 1.000 39.82259 ? 336 ASN   A CB  1 
ATOM   1029 C CG  . ASN   A 1 140 ? 3.39600   1.74300   -35.95600 1.000 39.76213 ? 336 ASN   A CG  1 
ATOM   1030 O OD1 . ASN   A 1 140 ? 2.38900   2.35100   -36.32400 1.000 42.04859 ? 336 ASN   A OD1 1 
ATOM   1031 N ND2 . ASN   A 1 140 ? 3.96900   1.95200   -34.78000 1.000 31.82509 ? 336 ASN   A ND2 1 
ATOM   1032 N N   . GLY   A 1 141 ? 4.33200   -2.71600  -37.48700 1.000 42.87726 ? 337 GLY   A N   1 
ATOM   1033 C CA  . GLY   A 1 141 ? 4.85700   -3.70300  -38.40300 1.000 39.72310 ? 337 GLY   A CA  1 
ATOM   1034 C C   . GLY   A 1 141 ? 4.32200   -5.08200  -38.08400 1.000 43.31271 ? 337 GLY   A C   1 
ATOM   1035 O O   . GLY   A 1 141 ? 3.96700   -5.39700  -36.94600 1.000 39.49550 ? 337 GLY   A O   1 
ATOM   1036 N N   . PHE   A 1 142 ? 4.27600   -5.91900  -39.12200 1.000 40.96541 ? 338 PHE   A N   1 
ATOM   1037 C CA  . PHE   A 1 142 ? 3.75700   -7.28100  -39.02600 1.000 35.56783 ? 338 PHE   A CA  1 
ATOM   1038 C C   . PHE   A 1 142 ? 4.68600   -8.18600  -39.82700 1.000 41.13732 ? 338 PHE   A C   1 
ATOM   1039 O O   . PHE   A 1 142 ? 4.67400   -8.15200  -41.06100 1.000 42.41803 ? 338 PHE   A O   1 
ATOM   1040 C CB  . PHE   A 1 142 ? 2.31700   -7.35300  -39.54600 1.000 35.35081 ? 338 PHE   A CB  1 
ATOM   1041 C CG  . PHE   A 1 142 ? 1.73500   -8.74500  -39.57500 1.000 39.68742 ? 338 PHE   A CG  1 
ATOM   1042 C CD1 . PHE   A 1 142 ? 1.11400   -9.27800  -38.45000 1.000 41.64640 ? 338 PHE   A CD1 1 
ATOM   1043 C CD2 . PHE   A 1 142 ? 1.78100   -9.50900  -40.73200 1.000 41.08044 ? 338 PHE   A CD2 1 
ATOM   1044 C CE1 . PHE   A 1 142 ? 0.56700   -10.55700 -38.47900 1.000 41.82097 ? 338 PHE   A CE1 1 
ATOM   1045 C CE2 . PHE   A 1 142 ? 1.23900   -10.78600 -40.76500 1.000 41.36268 ? 338 PHE   A CE2 1 
ATOM   1046 C CZ  . PHE   A 1 142 ? 0.63000   -11.30800 -39.63800 1.000 44.83426 ? 338 PHE   A CZ  1 
ATOM   1047 N N   . ILE   A 1 143 ? 5.50700   -8.97100  -39.13700 1.000 38.80845 ? 339 ILE   A N   1 
ATOM   1048 C CA  . ILE   A 1 143 ? 6.47000   -9.85400  -39.78700 1.000 45.53098 ? 339 ILE   A CA  1 
ATOM   1049 C C   . ILE   A 1 143 ? 5.83000   -11.22900 -39.93800 1.000 44.41850 ? 339 ILE   A C   1 
ATOM   1050 O O   . ILE   A 1 143 ? 5.29800   -11.78800 -38.97100 1.000 36.79999 ? 339 ILE   A O   1 
ATOM   1051 C CB  . ILE   A 1 143 ? 7.79300   -9.91300  -39.00000 1.000 45.15302 ? 339 ILE   A CB  1 
ATOM   1052 C CG1 . ILE   A 1 143 ? 8.81500   -10.80100 -39.71000 1.000 46.02370 ? 339 ILE   A CG1 1 
ATOM   1053 C CG2 . ILE   A 1 143 ? 7.57500   -10.38100 -37.57900 1.000 45.72389 ? 339 ILE   A CG2 1 
ATOM   1054 C CD1 . ILE   A 1 143 ? 10.22700  -10.61100 -39.20300 1.000 44.17564 ? 339 ILE   A CD1 1 
ATOM   1055 N N   . THR   A 1 144 ? 5.84000   -11.76000 -41.15800 1.000 44.32607 ? 340 THR   A N   1 
ATOM   1056 C CA  . THR   A 1 144 ? 5.10100   -12.98900 -41.41400 1.000 40.57209 ? 340 THR   A CA  1 
ATOM   1057 C C   . THR   A 1 144 ? 5.81200   -14.19200 -40.81100 1.000 38.98366 ? 340 THR   A C   1 
ATOM   1058 O O   . THR   A 1 144 ? 7.04200   -14.24000 -40.70900 1.000 40.68704 ? 340 THR   A O   1 
ATOM   1059 C CB  . THR   A 1 144 ? 4.89000   -13.21500 -42.91600 1.000 43.73223 ? 340 THR   A CB  1 
ATOM   1060 O OG1 . THR   A 1 144 ? 6.11400   -13.65900 -43.51800 1.000 39.68444 ? 340 THR   A OG1 1 
ATOM   1061 C CG2 . THR   A 1 144 ? 4.41900   -11.94000 -43.58100 1.000 41.55620 ? 340 THR   A CG2 1 
ATOM   1062 N N   . ARG   A 1 145 ? 5.00100   -15.16800 -40.40200 1.000 37.37308 ? 341 ARG   A N   1 
ATOM   1063 C CA  . ARG   A 1 145 ? 5.52700   -16.42000 -39.87600 1.000 39.86006 ? 341 ARG   A CA  1 
ATOM   1064 C C   . ARG   A 1 145 ? 6.38500   -17.14100 -40.91000 1.000 45.30836 ? 341 ARG   A C   1 
ATOM   1065 O O   . ARG   A 1 145 ? 7.38800   -17.77700 -40.56500 1.000 45.49832 ? 341 ARG   A O   1 
ATOM   1066 C CB  . ARG   A 1 145 ? 4.36000   -17.29200 -39.43100 1.000 42.98776 ? 341 ARG   A CB  1 
ATOM   1067 C CG  . ARG   A 1 145 ? 4.71600   -18.63900 -38.86300 1.000 43.41762 ? 341 ARG   A CG  1 
ATOM   1068 C CD  . ARG   A 1 145 ? 3.42900   -19.30600 -38.43500 1.000 40.31179 ? 341 ARG   A CD  1 
ATOM   1069 N NE  . ARG   A 1 145 ? 3.64700   -20.48500 -37.61300 1.000 41.68738 ? 341 ARG   A NE  1 
ATOM   1070 C CZ  . ARG   A 1 145 ? 2.66400   -21.21200 -37.10600 1.000 40.43132 ? 341 ARG   A CZ  1 
ATOM   1071 N NH1 . ARG   A 1 145 ? 1.39600   -20.87500 -37.28200 1.000 41.86014 ? 341 ARG   A NH1 1 
ATOM   1072 N NH2 . ARG   A 1 145 ? 2.96000   -22.30400 -36.40900 1.000 40.62318 ? 341 ARG   A NH2 1 
ATOM   1073 N N   . GLU   A 1 146 ? 6.01400   -17.04600 -42.18600 1.000 46.41105 ? 342 GLU   A N   1 
ATOM   1074 C CA  . GLU   A 1 146 ? 6.77300   -17.76400 -43.20200 1.000 49.88541 ? 342 GLU   A CA  1 
ATOM   1075 C C   . GLU   A 1 146 ? 8.10100   -17.08300 -43.49900 1.000 47.96962 ? 342 GLU   A C   1 
ATOM   1076 O O   . GLU   A 1 146 ? 9.07900   -17.76400 -43.82800 1.000 48.49555 ? 342 GLU   A O   1 
ATOM   1077 C CB  . GLU   A 1 146 ? 5.94600   -17.91700 -44.47600 1.000 45.24446 ? 342 GLU   A CB  1 
ATOM   1078 C CG  . GLU   A 1 146 ? 5.10400   -19.17400 -44.44100 1.000 58.64827 ? 342 GLU   A CG  1 
ATOM   1079 C CD  . GLU   A 1 146 ? 5.93000   -20.42000 -44.69700 1.000 58.82969 ? 342 GLU   A CD  1 
ATOM   1080 O OE1 . GLU   A 1 146 ? 7.10800   -20.28600 -45.09500 1.000 59.17771 ? 342 GLU   A OE1 1 
ATOM   1081 O OE2 . GLU   A 1 146 ? 5.41200   -21.53000 -44.46000 1.000 63.84597 ? 342 GLU   A OE2 1 
ATOM   1082 N N   . PHE   A 1 147 ? 8.16900   -15.75400 -43.37000 1.000 43.95805 ? 343 PHE   A N   1 
ATOM   1083 C CA  . PHE   A 1 147 ? 9.45100   -15.07700 -43.53100 1.000 44.16403 ? 343 PHE   A CA  1 
ATOM   1084 C C   . PHE   A 1 147 ? 10.42600  -15.49700 -42.44000 1.000 48.10471 ? 343 PHE   A C   1 
ATOM   1085 O O   . PHE   A 1 147 ? 11.60400  -15.76100 -42.71100 1.000 45.54279 ? 343 PHE   A O   1 
ATOM   1086 C CB  . PHE   A 1 147 ? 9.25800   -13.56100 -43.53100 1.000 44.37678 ? 343 PHE   A CB  1 
ATOM   1087 C CG  . PHE   A 1 147 ? 10.54600  -12.79400 -43.62600 1.000 48.10030 ? 343 PHE   A CG  1 
ATOM   1088 C CD1 . PHE   A 1 147 ? 11.46100  -13.07800 -44.62800 1.000 48.28815 ? 343 PHE   A CD1 1 
ATOM   1089 C CD2 . PHE   A 1 147 ? 10.84700  -11.79500 -42.71200 1.000 49.28060 ? 343 PHE   A CD2 1 
ATOM   1090 C CE1 . PHE   A 1 147 ? 12.65500  -12.38100 -44.72000 1.000 47.28056 ? 343 PHE   A CE1 1 
ATOM   1091 C CE2 . PHE   A 1 147 ? 12.03900  -11.09000 -42.79900 1.000 51.24365 ? 343 PHE   A CE2 1 
ATOM   1092 C CZ  . PHE   A 1 147 ? 12.94500  -11.38500 -43.80600 1.000 51.99319 ? 343 PHE   A CZ  1 
ATOM   1093 N N   . LEU   A 1 148 ? 9.94900   -15.56500 -41.19200 1.000 47.27542 ? 344 LEU   A N   1 
ATOM   1094 C CA  . LEU   A 1 148 ? 10.80500  -16.00200 -40.09400 1.000 45.54739 ? 344 LEU   A CA  1 
ATOM   1095 C C   . LEU   A 1 148 ? 11.31500  -17.42000 -40.32000 1.000 49.23003 ? 344 LEU   A C   1 
ATOM   1096 O O   . LEU   A 1 148 ? 12.48400  -17.71900 -40.05000 1.000 52.55798 ? 344 LEU   A O   1 
ATOM   1097 C CB  . LEU   A 1 148 ? 10.04500  -15.90400 -38.77000 1.000 39.82646 ? 344 LEU   A CB  1 
ATOM   1098 C CG  . LEU   A 1 148 ? 9.79000   -14.47500 -38.29100 1.000 38.90115 ? 344 LEU   A CG  1 
ATOM   1099 C CD1 . LEU   A 1 148 ? 8.62900   -14.42600 -37.31100 1.000 38.63524 ? 344 LEU   A CD1 1 
ATOM   1100 C CD2 . LEU   A 1 148 ? 11.06200  -13.92800 -37.67200 1.000 40.68297 ? 344 LEU   A CD2 1 
ATOM   1101 N N   . LYS   A 1 149 ? 10.45100  -18.31000 -40.80900 1.000 43.74285 ? 345 LYS   A N   1 
ATOM   1102 C CA  . LYS   A 1 149 ? 10.88800  -19.67200 -41.09900 1.000 53.82824 ? 345 LYS   A CA  1 
ATOM   1103 C C   . LYS   A 1 149 ? 11.90700  -19.70600 -42.23300 1.000 53.99806 ? 345 LYS   A C   1 
ATOM   1104 O O   . LYS   A 1 149 ? 12.72200  -20.63200 -42.30700 1.000 56.34134 ? 345 LYS   A O   1 
ATOM   1105 C CB  . LYS   A 1 149 ? 9.68200   -20.54400 -41.44400 1.000 55.06595 ? 345 LYS   A CB  1 
ATOM   1106 C CG  . LYS   A 1 149 ? 8.91900   -21.04100 -40.23100 1.000 55.47071 ? 345 LYS   A CG  1 
ATOM   1107 C CD  . LYS   A 1 149 ? 8.00900   -22.20700 -40.58900 1.000 59.02166 ? 345 LYS   A CD  1 
ATOM   1108 C CE  . LYS   A 1 149 ? 6.61600   -21.72300 -40.97000 1.000 55.74503 ? 345 LYS   A CE  1 
ATOM   1109 N NZ  . LYS   A 1 149 ? 5.63200   -22.84700 -41.00500 1.000 61.94862 ? 345 LYS   A NZ  1 
ATOM   1110 N N   . SER   A 1 150 ? 11.88300  -18.70600 -43.11700 1.000 53.72497 ? 346 SER   A N   1 
ATOM   1111 C CA  . SER   A 1 150 ? 12.76500  -18.66800 -44.27900 1.000 52.19989 ? 346 SER   A CA  1 
ATOM   1112 C C   . SER   A 1 150 ? 14.17200  -18.17700 -43.95700 1.000 56.30520 ? 346 SER   A C   1 
ATOM   1113 O O   . SER   A 1 150 ? 15.03600  -18.21700 -44.83900 1.000 53.80068 ? 346 SER   A O   1 
ATOM   1114 C CB  . SER   A 1 150 ? 12.15700  -17.78100 -45.36600 1.000 47.72157 ? 346 SER   A CB  1 
ATOM   1115 O OG  . SER   A 1 150 ? 12.54300  -16.42700 -45.18900 1.000 52.89786 ? 346 SER   A OG  1 
ATOM   1116 N N   . LEU   A 1 151 ? 14.42300  -17.71300 -42.73500 1.000 54.94394 ? 347 LEU   A N   1 
ATOM   1117 C CA  . LEU   A 1 151 ? 15.76100  -17.28400 -42.35700 1.000 50.89419 ? 347 LEU   A CA  1 
ATOM   1118 C C   . LEU   A 1 151 ? 16.68200  -18.49300 -42.18800 1.000 54.38040 ? 347 LEU   A C   1 
ATOM   1119 O O   . LEU   A 1 151 ? 16.25900  -19.65100 -42.24700 1.000 49.85112 ? 347 LEU   A O   1 
ATOM   1120 C CB  . LEU   A 1 151 ? 15.71700  -16.46200 -41.06900 1.000 51.93889 ? 347 LEU   A CB  1 
ATOM   1121 C CG  . LEU   A 1 151 ? 14.74700  -15.28000 -41.06200 1.000 48.64525 ? 347 LEU   A CG  1 
ATOM   1122 C CD1 . LEU   A 1 151 ? 14.58500  -14.74700 -39.65900 1.000 50.72845 ? 347 LEU   A CD1 1 
ATOM   1123 C CD2 . LEU   A 1 151 ? 15.23600  -14.18100 -41.99100 1.000 50.40082 ? 347 LEU   A CD2 1 
ATOM   1124 N N   . ARG   A 1 152 ? 17.96300  -18.21100 -41.97300 1.000 54.43727 ? 348 ARG   A N   1 
ATOM   1125 C CA  . ARG   A 1 152 ? 18.95300  -19.26600 -41.83100 1.000 59.38818 ? 348 ARG   A CA  1 
ATOM   1126 C C   . ARG   A 1 152 ? 19.07400  -19.70000 -40.37500 1.000 62.89874 ? 348 ARG   A C   1 
ATOM   1127 O O   . ARG   A 1 152 ? 18.77200  -18.94100 -39.44800 1.000 59.80091 ? 348 ARG   A O   1 
ATOM   1128 C CB  . ARG   A 1 152 ? 20.31700  -18.81500 -42.36000 1.000 58.17562 ? 348 ARG   A CB  1 
ATOM   1129 C CG  . ARG   A 1 152 ? 20.98000  -17.69600 -41.57000 1.000 58.99055 ? 348 ARG   A CG  1 
ATOM   1130 C CD  . ARG   A 1 152 ? 22.44000  -18.02500 -41.29300 1.000 61.83553 ? 348 ARG   A CD  1 
ATOM   1131 N NE  . ARG   A 1 152 ? 23.21300  -16.85900 -40.87900 1.000 54.52088 ? 348 ARG   A NE  1 
ATOM   1132 C CZ  . ARG   A 1 152 ? 23.86900  -16.76300 -39.73000 1.000 59.25709 ? 348 ARG   A CZ  1 
ATOM   1133 N NH1 . ARG   A 1 152 ? 23.83000  -17.73100 -38.82700 1.000 59.15006 ? 348 ARG   A NH1 1 
ATOM   1134 N NH2 . ARG   A 1 152 ? 24.58100  -15.66900 -39.47900 1.000 59.19382 ? 348 ARG   A NH2 1 
ATOM   1135 N N   . LYS   A 1 153 ? 19.51300  -20.94400 -40.18900 1.000 58.33155 ? 349 LYS   A N   1 
ATOM   1136 C CA  . LYS   A 1 153 ? 19.70400  -21.49400 -38.85800 1.000 57.33246 ? 349 LYS   A CA  1 
ATOM   1137 C C   . LYS   A 1 153 ? 20.68300  -20.63100 -38.06200 1.000 61.86999 ? 349 LYS   A C   1 
ATOM   1138 O O   . LYS   A 1 153 ? 21.63000  -20.07200 -38.62400 1.000 61.05447 ? 349 LYS   A O   1 
ATOM   1139 C CB  . LYS   A 1 153 ? 20.23200  -22.92600 -38.94900 1.000 64.91423 ? 349 LYS   A CB  1 
ATOM   1140 C CG  . LYS   A 1 153 ? 19.17500  -23.99000 -39.21600 1.000 63.25466 ? 349 LYS   A CG  1 
ATOM   1141 C CD  . LYS   A 1 153 ? 19.17200  -25.04300 -38.11200 1.000 60.42800 ? 349 LYS   A CD  1 
ATOM   1142 C CE  . LYS   A 1 153 ? 18.25400  -26.21000 -38.44800 1.000 67.99013 ? 349 LYS   A CE  1 
ATOM   1143 N NZ  . LYS   A 1 153 ? 16.95200  -26.14000 -37.72700 1.000 65.93004 ? 349 LYS   A NZ  1 
ATOM   1144 N N   . PRO   A 1 154 ? 20.47700  -20.50000 -36.74000 1.000 60.68557 ? 350 PRO   A N   1 
ATOM   1145 C CA  . PRO   A 1 154 ? 19.35600  -21.08000 -35.99600 1.000 55.51583 ? 350 PRO   A CA  1 
ATOM   1146 C C   . PRO   A 1 154 ? 18.19800  -20.09900 -35.85600 1.000 58.79133 ? 350 PRO   A C   1 
ATOM   1147 O O   . PRO   A 1 154 ? 17.25200  -20.35500 -35.11000 1.000 57.86424 ? 350 PRO   A O   1 
ATOM   1148 C CB  . PRO   A 1 154 ? 19.97600  -21.37700 -34.63500 1.000 59.33085 ? 350 PRO   A CB  1 
ATOM   1149 C CG  . PRO   A 1 154 ? 20.92800  -20.22700 -34.44300 1.000 56.13987 ? 350 PRO   A CG  1 
ATOM   1150 C CD  . PRO   A 1 154 ? 21.44200  -19.85500 -35.83100 1.000 61.68591 ? 350 PRO   A CD  1 
ATOM   1151 N N   . PHE   A 1 155 ? 18.28700  -18.98000 -36.57800 1.000 59.21072 ? 351 PHE   A N   1 
ATOM   1152 C CA  . PHE   A 1 155 ? 17.34400  -17.88600 -36.37600 1.000 56.06880 ? 351 PHE   A CA  1 
ATOM   1153 C C   . PHE   A 1 155 ? 15.92800  -18.29400 -36.75900 1.000 57.23838 ? 351 PHE   A C   1 
ATOM   1154 O O   . PHE   A 1 155 ? 14.96200  -17.90800 -36.09000 1.000 53.23847 ? 351 PHE   A O   1 
ATOM   1155 C CB  . PHE   A 1 155 ? 17.79700  -16.66700 -37.17700 1.000 53.56402 ? 351 PHE   A CB  1 
ATOM   1156 C CG  . PHE   A 1 155 ? 19.07800  -16.06800 -36.67800 1.000 56.16566 ? 351 PHE   A CG  1 
ATOM   1157 C CD1 . PHE   A 1 155 ? 20.28600  -16.40300 -37.26700 1.000 56.11886 ? 351 PHE   A CD1 1 
ATOM   1158 C CD2 . PHE   A 1 155 ? 19.07900  -15.18900 -35.60600 1.000 52.41947 ? 351 PHE   A CD2 1 
ATOM   1159 C CE1 . PHE   A 1 155 ? 21.47300  -15.86300 -36.80600 1.000 60.17065 ? 351 PHE   A CE1 1 
ATOM   1160 C CE2 . PHE   A 1 155 ? 20.26500  -14.64300 -35.14000 1.000 56.24776 ? 351 PHE   A CE2 1 
ATOM   1161 C CZ  . PHE   A 1 155 ? 21.46300  -14.98100 -35.74100 1.000 61.39253 ? 351 PHE   A CZ  1 
ATOM   1162 N N   . CYS   A 1 156 ? 15.78500  -19.08400 -37.82500 1.000 55.47072 ? 352 CYS   A N   1 
ATOM   1163 C CA  . CYS   A 1 156 ? 14.47600  -19.58500 -38.22400 1.000 54.13245 ? 352 CYS   A CA  1 
ATOM   1164 C C   . CYS   A 1 156 ? 13.88100  -20.55500 -37.21100 1.000 54.01764 ? 352 CYS   A C   1 
ATOM   1165 O O   . CYS   A 1 156 ? 12.70800  -20.92200 -37.34700 1.000 52.63450 ? 352 CYS   A O   1 
ATOM   1166 C CB  . CYS   A 1 156 ? 14.57200  -20.26200 -39.59300 1.000 55.06189 ? 352 CYS   A CB  1 
ATOM   1167 S SG  . CYS   A 1 156 ? 15.60500  -21.75100 -39.62300 1.000 62.61865 ? 352 CYS   A SG  1 
ATOM   1168 N N   . ASP   A 1 157 ? 14.65000  -20.97000 -36.20900 1.000 52.68803 ? 353 ASP   A N   1 
ATOM   1169 C CA  . ASP   A 1 157 ? 14.19800  -21.92800 -35.21100 1.000 53.74327 ? 353 ASP   A CA  1 
ATOM   1170 C C   . ASP   A 1 157 ? 13.65200  -21.26500 -33.95300 1.000 53.81305 ? 353 ASP   A C   1 
ATOM   1171 O O   . ASP   A 1 157 ? 13.17800  -21.96900 -33.05600 1.000 52.32685 ? 353 ASP   A O   1 
ATOM   1172 C CB  . ASP   A 1 157 ? 15.35000  -22.85700 -34.82000 1.000 54.46179 ? 353 ASP   A CB  1 
ATOM   1173 C CG  . ASP   A 1 157 ? 15.80300  -23.73900 -35.96400 1.000 62.24731 ? 353 ASP   A CG  1 
ATOM   1174 O OD1 . ASP   A 1 157 ? 16.97900  -24.15200 -35.95600 1.000 63.30874 ? 353 ASP   A OD1 1 
ATOM   1175 O OD2 . ASP   A 1 157 ? 14.99200  -24.00000 -36.88100 1.000 56.55166 ? 353 ASP   A OD2 1 
ATOM   1176 N N   . ILE   A 1 158 ? 13.70500  -19.93800 -33.85800 1.000 53.18682 ? 354 ILE   A N   1 
ATOM   1177 C CA  . ILE   A 1 158 ? 13.40500  -19.28400 -32.58900 1.000 53.87956 ? 354 ILE   A CA  1 
ATOM   1178 C C   . ILE   A 1 158 ? 11.90200  -19.10600 -32.40600 1.000 52.99868 ? 354 ILE   A C   1 
ATOM   1179 O O   . ILE   A 1 158 ? 11.33500  -19.50600 -31.38400 1.000 46.43873 ? 354 ILE   A O   1 
ATOM   1180 C CB  . ILE   A 1 158 ? 14.15100  -17.94300 -32.49100 1.000 51.37759 ? 354 ILE   A CB  1 
ATOM   1181 C CG1 . ILE   A 1 158 ? 15.66100  -18.17400 -32.58100 1.000 50.71644 ? 354 ILE   A CG1 1 
ATOM   1182 C CG2 . ILE   A 1 158 ? 13.79900  -17.23600 -31.18700 1.000 47.92335 ? 354 ILE   A CG2 1 
ATOM   1183 C CD1 . ILE   A 1 158 ? 16.47800  -16.90000 -32.58200 1.000 55.14117 ? 354 ILE   A CD1 1 
ATOM   1184 N N   . MET   A 1 159 ? 11.22900  -18.51900 -33.39400 1.000 48.23920 ? 355 MET   A N   1 
ATOM   1185 C CA  . MET   A 1 159 ? 9.86500   -18.06600 -33.15300 1.000 47.53874 ? 355 MET   A CA  1 
ATOM   1186 C C   . MET   A 1 159 ? 8.83500   -19.16600 -33.38700 1.000 45.31106 ? 355 MET   A C   1 
ATOM   1187 O O   . MET   A 1 159 ? 7.76600   -19.14200 -32.77100 1.000 43.37748 ? 355 MET   A O   1 
ATOM   1188 C CB  . MET   A 1 159 ? 9.54600   -16.86000 -34.03500 1.000 40.26205 ? 355 MET   A CB  1 
ATOM   1189 C CG  . MET   A 1 159 ? 10.17600  -15.57800 -33.53200 1.000 43.99665 ? 355 MET   A CG  1 
ATOM   1190 S SD  . MET   A 1 159 ? 9.90600   -15.26400 -31.77800 1.000 57.25760 ? 355 MET   A SD  1 
ATOM   1191 C CE  . MET   A 1 159 ? 8.20200   -14.86300 -31.79500 1.000 35.96890 ? 355 MET   A CE  1 
ATOM   1192 N N   . GLU   A 1 160 ? 9.13500   -20.12800 -34.26300 1.000 49.50820 ? 356 GLU   A N   1 
ATOM   1193 C CA  . GLU   A 1 160 ? 8.18400   -21.18900 -34.60500 1.000 47.60887 ? 356 GLU   A CA  1 
ATOM   1194 C C   . GLU   A 1 160 ? 7.53800   -21.87700 -33.40600 1.000 41.64124 ? 356 GLU   A C   1 
ATOM   1195 O O   . GLU   A 1 160 ? 6.30700   -22.04900 -33.42000 1.000 38.38579 ? 356 GLU   A O   1 
ATOM   1196 C CB  . GLU   A 1 160 ? 8.87500   -22.22000 -35.51100 1.000 49.97599 ? 356 GLU   A CB  1 
ATOM   1197 C CG  . GLU   A 1 160 ? 7.93600   -23.14200 -36.30100 1.000 48.67656 ? 356 GLU   A CG  1 
ATOM   1198 C CD  . GLU   A 1 160 ? 6.64500   -22.48400 -36.78500 1.000 54.07585 ? 356 GLU   A CD  1 
ATOM   1199 O OE1 . GLU   A 1 160 ? 5.60700   -23.17900 -36.80100 1.000 56.35227 ? 356 GLU   A OE1 1 
ATOM   1200 O OE2 . GLU   A 1 160 ? 6.66600   -21.30900 -37.21900 1.000 47.89604 ? 356 GLU   A OE2 1 
ATOM   1201 N N   . PRO   A 1 161 ? 8.26600   -22.31000 -32.36900 1.000 43.57517 ? 357 PRO   A N   1 
ATOM   1202 C CA  . PRO   A 1 161 ? 7.56500   -22.91400 -31.21800 1.000 44.36146 ? 357 PRO   A CA  1 
ATOM   1203 C C   . PRO   A 1 161 ? 6.69600   -21.92200 -30.45700 1.000 44.04418 ? 357 PRO   A C   1 
ATOM   1204 O O   . PRO   A 1 161 ? 5.73200   -22.33100 -29.79300 1.000 34.83538 ? 357 PRO   A O   1 
ATOM   1205 C CB  . PRO   A 1 161 ? 8.69600   -23.45900 -30.33000 1.000 46.85793 ? 357 PRO   A CB  1 
ATOM   1206 C CG  . PRO   A 1 161 ? 9.97300   -23.19500 -31.03200 1.000 46.41544 ? 357 PRO   A CG  1 
ATOM   1207 C CD  . PRO   A 1 161 ? 9.73000   -22.28600 -32.19000 1.000 43.99249 ? 357 PRO   A CD  1 
ATOM   1208 N N   . LYS   A 1 162 ? 7.00500   -20.62500 -30.53400 1.000 44.13949 ? 358 LYS   A N   1 
ATOM   1209 C CA  . LYS   A 1 162 ? 6.16800   -19.63400 -29.86300 1.000 38.60461 ? 358 LYS   A CA  1 
ATOM   1210 C C   . LYS   A 1 162 ? 4.84500   -19.47900 -30.59500 1.000 38.93369 ? 358 LYS   A C   1 
ATOM   1211 O O   . LYS   A 1 162 ? 3.78900   -19.36500 -29.96000 1.000 37.09221 ? 358 LYS   A O   1 
ATOM   1212 C CB  . LYS   A 1 162 ? 6.89300   -18.28700 -29.76900 1.000 37.53446 ? 358 LYS   A CB  1 
ATOM   1213 C CG  . LYS   A 1 162 ? 7.96000   -18.20600 -28.67900 1.000 40.30789 ? 358 LYS   A CG  1 
ATOM   1214 C CD  . LYS   A 1 162 ? 9.15800   -19.07400 -29.03500 1.000 42.79853 ? 358 LYS   A CD  1 
ATOM   1215 C CE  . LYS   A 1 162 ? 10.31300  -18.92200 -28.07100 1.000 43.89901 ? 358 LYS   A CE  1 
ATOM   1216 N NZ  . LYS   A 1 162 ? 11.46800  -19.75700 -28.52800 1.000 44.70131 ? 358 LYS   A NZ  1 
ATOM   1217 N N   . PHE   A 1 163 ? 4.88700   -19.47800 -31.93500 1.000 35.69871 ? 359 PHE   A N   1 
ATOM   1218 C CA  . PHE   A 1 163 ? 3.66000   -19.50300 -32.72400 1.000 36.45272 ? 359 PHE   A CA  1 
ATOM   1219 C C   . PHE   A 1 163 ? 2.79400   -20.70000 -32.35000 1.000 37.72986 ? 359 PHE   A C   1 
ATOM   1220 O O   . PHE   A 1 163 ? 1.57400   -20.57200 -32.18800 1.000 38.13822 ? 359 PHE   A O   1 
ATOM   1221 C CB  . PHE   A 1 163 ? 3.99200   -19.54000 -34.21900 1.000 37.07093 ? 359 PHE   A CB  1 
ATOM   1222 C CG  . PHE   A 1 163 ? 4.26800   -18.19400 -34.81200 1.000 35.35199 ? 359 PHE   A CG  1 
ATOM   1223 C CD1 . PHE   A 1 163 ? 3.23400   -17.30700 -35.05100 1.000 32.92015 ? 359 PHE   A CD1 1 
ATOM   1224 C CD2 . PHE   A 1 163 ? 5.56000   -17.81300 -35.12900 1.000 35.65957 ? 359 PHE   A CD2 1 
ATOM   1225 C CE1 . PHE   A 1 163 ? 3.48200   -16.05900 -35.59400 1.000 36.83805 ? 359 PHE   A CE1 1 
ATOM   1226 C CE2 . PHE   A 1 163 ? 5.81500   -16.57200 -35.67400 1.000 35.67176 ? 359 PHE   A CE2 1 
ATOM   1227 C CZ  . PHE   A 1 163 ? 4.77500   -15.69300 -35.90500 1.000 37.07655 ? 359 PHE   A CZ  1 
ATOM   1228 N N   . ASP   A 1 164 ? 3.41100   -21.87500 -32.20900 1.000 40.47704 ? 360 ASP   A N   1 
ATOM   1229 C CA  . ASP   A 1 164 ? 2.64800   -23.07500 -31.88100 1.000 39.71270 ? 360 ASP   A CA  1 
ATOM   1230 C C   . ASP   A 1 164 ? 2.00800   -22.95900 -30.50300 1.000 37.58032 ? 360 ASP   A C   1 
ATOM   1231 O O   . ASP   A 1 164 ? 0.82700   -23.28200 -30.32800 1.000 37.00004 ? 360 ASP   A O   1 
ATOM   1232 C CB  . ASP   A 1 164 ? 3.55300   -24.30500 -31.96600 1.000 42.38531 ? 360 ASP   A CB  1 
ATOM   1233 C CG  . ASP   A 1 164 ? 3.65100   -24.85200 -33.38100 1.000 51.03704 ? 360 ASP   A CG  1 
ATOM   1234 O OD1 . ASP   A 1 164 ? 4.65500   -25.52400 -33.69700 1.000 57.46643 ? 360 ASP   A OD1 1 
ATOM   1235 O OD2 . ASP   A 1 164 ? 2.72400   -24.59800 -34.18200 1.000 49.16703 ? 360 ASP   A OD2 1 
ATOM   1236 N N   . PHE   A 1 165 ? 2.76700   -22.49200 -29.50800 1.000 38.42347 ? 361 PHE   A N   1 
ATOM   1237 C CA  . PHE   A 1 165 ? 2.16800   -22.25000 -28.19900 1.000 36.37175 ? 361 PHE   A CA  1 
ATOM   1238 C C   . PHE   A 1 165 ? 1.03300   -21.24100 -28.30100 1.000 37.60582 ? 361 PHE   A C   1 
ATOM   1239 O O   . PHE   A 1 165 ? -0.05200  -21.44700 -27.74300 1.000 38.17967 ? 361 PHE   A O   1 
ATOM   1240 C CB  . PHE   A 1 165 ? 3.22200   -21.76100 -27.20400 1.000 35.46067 ? 361 PHE   A CB  1 
ATOM   1241 C CG  . PHE   A 1 165 ? 2.65100   -21.40300 -25.85800 1.000 38.26893 ? 361 PHE   A CG  1 
ATOM   1242 C CD1 . PHE   A 1 165 ? 2.54400   -22.36100 -24.86200 1.000 37.12290 ? 361 PHE   A CD1 1 
ATOM   1243 C CD2 . PHE   A 1 165 ? 2.20300   -20.11600 -25.59400 1.000 36.24531 ? 361 PHE   A CD2 1 
ATOM   1244 C CE1 . PHE   A 1 165 ? 2.01100   -22.03600 -23.62100 1.000 39.33194 ? 361 PHE   A CE1 1 
ATOM   1245 C CE2 . PHE   A 1 165 ? 1.66400   -19.78900 -24.36000 1.000 32.09421 ? 361 PHE   A CE2 1 
ATOM   1246 C CZ  . PHE   A 1 165 ? 1.56600   -20.75100 -23.37700 1.000 35.41813 ? 361 PHE   A CZ  1 
ATOM   1247 N N   . ALA   A 1 166 ? 1.27100   -20.14000 -29.01400 1.000 33.72070 ? 362 ALA   A N   1 
ATOM   1248 C CA  . ALA   A 1 166 ? 0.29700   -19.05600 -29.06000 1.000 35.06249 ? 362 ALA   A CA  1 
ATOM   1249 C C   . ALA   A 1 166 ? -1.01700  -19.50700 -29.68200 1.000 38.80552 ? 362 ALA   A C   1 
ATOM   1250 O O   . ALA   A 1 166 ? -2.09500  -19.11900 -29.21700 1.000 35.91280 ? 362 ALA   A O   1 
ATOM   1251 C CB  . ALA   A 1 166 ? 0.87400   -17.87300 -29.83600 1.000 38.43035 ? 362 ALA   A CB  1 
ATOM   1252 N N   . MET   A 1 167 ? -0.94900  -20.33000 -30.73400 1.000 39.25522 ? 363 MET   A N   1 
ATOM   1253 C CA  . MET   A 1 167 ? -2.16100  -20.77000 -31.42300 1.000 43.14550 ? 363 MET   A CA  1 
ATOM   1254 C C   . MET   A 1 167 ? -3.11200  -21.48700 -30.46800 1.000 42.75320 ? 363 MET   A C   1 
ATOM   1255 O O   . MET   A 1 167 ? -4.31900  -21.21400 -30.45300 1.000 40.53885 ? 363 MET   A O   1 
ATOM   1256 C CB  . MET   A 1 167 ? -1.78200  -21.67300 -32.59900 1.000 41.36780 ? 363 MET   A CB  1 
ATOM   1257 C CG  . MET   A 1 167 ? -1.40400  -20.93600 -33.89000 1.000 41.95223 ? 363 MET   A CG  1 
ATOM   1258 S SD  . MET   A 1 167 ? -2.17600  -19.32600 -34.15800 1.000 49.80022 ? 363 MET   A SD  1 
ATOM   1259 C CE  . MET   A 1 167 ? -0.94200  -18.20700 -33.47000 1.000 45.21472 ? 363 MET   A CE  1 
ATOM   1260 N N   . LYS   A 1 168 ? -2.58600  -22.40500 -29.65400 1.000 37.06952 ? 364 LYS   A N   1 
ATOM   1261 C CA  . LYS   A 1 168 ? -3.44200  -23.11700 -28.71000 1.000 42.41635 ? 364 LYS   A CA  1 
ATOM   1262 C C   . LYS   A 1 168 ? -3.84800  -22.22100 -27.54400 1.000 42.95730 ? 364 LYS   A C   1 
ATOM   1263 O O   . LYS   A 1 168 ? -5.01400  -22.21900 -27.12800 1.000 43.43826 ? 364 LYS   A O   1 
ATOM   1264 C CB  . LYS   A 1 168 ? -2.74200  -24.38000 -28.20400 1.000 43.21047 ? 364 LYS   A CB  1 
ATOM   1265 C CG  . LYS   A 1 168 ? -2.77800  -25.53400 -29.19400 1.000 43.84574 ? 364 LYS   A CG  1 
ATOM   1266 C CD  . LYS   A 1 168 ? -1.83300  -26.66500 -28.79900 1.000 52.29807 ? 364 LYS   A CD  1 
ATOM   1267 C CE  . LYS   A 1 168 ? -0.42600  -26.17100 -28.48700 1.000 48.17147 ? 364 LYS   A CE  1 
ATOM   1268 N NZ  . LYS   A 1 168 ? 0.58800   -27.23300 -28.77800 1.000 50.20793 ? 364 LYS   A NZ  1 
ATOM   1269 N N   . PHE   A 1 169 ? -2.89700  -21.45900 -26.99600 1.000 42.06141 ? 365 PHE   A N   1 
ATOM   1270 C CA  . PHE   A 1 169 ? -3.22100  -20.50400 -25.93900 1.000 39.42972 ? 365 PHE   A CA  1 
ATOM   1271 C C   . PHE   A 1 169 ? -4.32400  -19.55400 -26.38900 1.000 39.25191 ? 365 PHE   A C   1 
ATOM   1272 O O   . PHE   A 1 169 ? -5.28600  -19.30500 -25.65400 1.000 38.69967 ? 365 PHE   A O   1 
ATOM   1273 C CB  . PHE   A 1 169 ? -1.95700  -19.73600 -25.54000 1.000 37.17221 ? 365 PHE   A CB  1 
ATOM   1274 C CG  . PHE   A 1 169 ? -2.05600  -19.01900 -24.21500 1.000 38.16235 ? 365 PHE   A CG  1 
ATOM   1275 C CD1 . PHE   A 1 169 ? -1.99200  -19.72300 -23.02100 1.000 36.23235 ? 365 PHE   A CD1 1 
ATOM   1276 C CD2 . PHE   A 1 169 ? -2.17300  -17.63600 -24.16600 1.000 41.13734 ? 365 PHE   A CD2 1 
ATOM   1277 C CE1 . PHE   A 1 169 ? -2.06800  -19.06500 -21.80400 1.000 37.73976 ? 365 PHE   A CE1 1 
ATOM   1278 C CE2 . PHE   A 1 169 ? -2.25200  -16.97100 -22.94300 1.000 35.29032 ? 365 PHE   A CE2 1 
ATOM   1279 C CZ  . PHE   A 1 169 ? -2.19700  -17.69200 -21.76700 1.000 36.07609 ? 365 PHE   A CZ  1 
ATOM   1280 N N   . ASN   A 1 170 ? -4.21500  -19.04000 -27.62000 1.000 40.40148 ? 366 ASN   A N   1 
ATOM   1281 C CA  . ASN   A 1 170 ? -5.21600  -18.11100 -28.13900 1.000 39.78267 ? 366 ASN   A CA  1 
ATOM   1282 C C   . ASN   A 1 170 ? -6.56600  -18.78400 -28.35100 1.000 44.01612 ? 366 ASN   A C   1 
ATOM   1283 O O   . ASN   A 1 170 ? -7.60200  -18.10700 -28.33200 1.000 41.07858 ? 366 ASN   A O   1 
ATOM   1284 C CB  . ASN   A 1 170 ? -4.73400  -17.49300 -29.45100 1.000 42.77659 ? 366 ASN   A CB  1 
ATOM   1285 C CG  . ASN   A 1 170 ? -3.67900  -16.42300 -29.23600 1.000 41.83169 ? 366 ASN   A CG  1 
ATOM   1286 O OD1 . ASN   A 1 170 ? -3.42000  -16.00900 -28.10400 1.000 40.05274 ? 366 ASN   A OD1 1 
ATOM   1287 N ND2 . ASN   A 1 170 ? -3.05600  -15.98000 -30.32100 1.000 36.01952 ? 366 ASN   A ND2 1 
ATOM   1288 N N   . ALA   A 1 171 ? -6.58000  -20.10400 -28.56100 1.000 41.54008 ? 367 ALA   A N   1 
ATOM   1289 C CA  . ALA   A 1 171 ? -7.84500  -20.81400 -28.70600 1.000 43.52744 ? 367 ALA   A CA  1 
ATOM   1290 C C   . ALA   A 1 171 ? -8.65300  -20.81100 -27.41400 1.000 47.11206 ? 367 ALA   A C   1 
ATOM   1291 O O   . ALA   A 1 171 ? -9.86100  -21.06400 -27.45300 1.000 47.90812 ? 367 ALA   A O   1 
ATOM   1292 C CB  . ALA   A 1 171 ? -7.60100  -22.25400 -29.16800 1.000 46.81146 ? 367 ALA   A CB  1 
ATOM   1293 N N   . LEU   A 1 172 ? -8.01800  -20.52800 -26.27500 1.000 47.67255 ? 368 LEU   A N   1 
ATOM   1294 C CA  . LEU   A 1 172 ? -8.73100  -20.41500 -25.00900 1.000 42.26401 ? 368 LEU   A CA  1 
ATOM   1295 C C   . LEU   A 1 172 ? -9.50500  -19.11000 -24.88600 1.000 43.07208 ? 368 LEU   A C   1 
ATOM   1296 O O   . LEU   A 1 172 ? -10.35100 -18.99400 -23.99200 1.000 41.66667 ? 368 LEU   A O   1 
ATOM   1297 C CB  . LEU   A 1 172 ? -7.74800  -20.55400 -23.84700 1.000 41.57098 ? 368 LEU   A CB  1 
ATOM   1298 C CG  . LEU   A 1 172 ? -6.93000  -21.84800 -23.86500 1.000 46.30035 ? 368 LEU   A CG  1 
ATOM   1299 C CD1 . LEU   A 1 172 ? -5.92800  -21.88300 -22.71700 1.000 40.31280 ? 368 LEU   A CD1 1 
ATOM   1300 C CD2 . LEU   A 1 172 ? -7.84900  -23.07400 -23.83300 1.000 46.32137 ? 368 LEU   A CD2 1 
ATOM   1301 N N   . GLU   A 1 173 ? -9.22800  -18.13400 -25.75200 1.000 41.49270 ? 369 GLU   A N   1 
ATOM   1302 C CA  . GLU   A 1 173 ? -9.99000  -16.88600 -25.82900 1.000 44.39001 ? 369 GLU   A CA  1 
ATOM   1303 C C   . GLU   A 1 173 ? -9.97000  -16.12400 -24.50400 1.000 41.69418 ? 369 GLU   A C   1 
ATOM   1304 O O   . GLU   A 1 173 ? -10.99200 -15.62700 -24.03000 1.000 43.04797 ? 369 GLU   A O   1 
ATOM   1305 C CB  . GLU   A 1 173 ? -11.42500 -17.15000 -26.29500 1.000 48.79741 ? 369 GLU   A CB  1 
ATOM   1306 C CG  . GLU   A 1 173 ? -11.50900 -17.75500 -27.69000 1.000 55.19942 ? 369 GLU   A CG  1 
ATOM   1307 C CD  . GLU   A 1 173 ? -12.86400 -18.37200 -27.98900 1.000 64.91193 ? 369 GLU   A CD  1 
ATOM   1308 O OE1 . GLU   A 1 173 ? -12.89900 -19.45700 -28.60900 1.000 67.47193 ? 369 GLU   A OE1 1 
ATOM   1309 O OE2 . GLU   A 1 173 ? -13.89300 -17.77700 -27.60200 1.000 69.03704 ? 369 GLU   A OE2 1 
ATOM   1310 N N   . LEU   A 1 174 ? -8.78600  -16.02700 -23.90600 1.000 38.39492 ? 370 LEU   A N   1 
ATOM   1311 C CA  . LEU   A 1 174 ? -8.61500  -15.16500 -22.74600 1.000 36.66961 ? 370 LEU   A CA  1 
ATOM   1312 C C   . LEU   A 1 174 ? -8.64100  -13.70000 -23.16800 1.000 41.90715 ? 370 LEU   A C   1 
ATOM   1313 O O   . LEU   A 1 174 ? -8.23100  -13.34100 -24.27600 1.000 40.80900 ? 370 LEU   A O   1 
ATOM   1314 C CB  . LEU   A 1 174 ? -7.29600  -15.46900 -22.03600 1.000 38.79271 ? 370 LEU   A CB  1 
ATOM   1315 C CG  . LEU   A 1 174 ? -6.94200  -16.91900 -21.69700 1.000 38.03542 ? 370 LEU   A CG  1 
ATOM   1316 C CD1 . LEU   A 1 174 ? -5.69800  -16.96000 -20.81100 1.000 34.85825 ? 370 LEU   A CD1 1 
ATOM   1317 C CD2 . LEU   A 1 174 ? -8.11000  -17.59900 -21.00600 1.000 40.19853 ? 370 LEU   A CD2 1 
ATOM   1318 N N   . ASP   A 1 175 ? -9.13600  -12.85100 -22.27400 1.000 38.87153 ? 371 ASP   A N   1 
ATOM   1319 C CA  . ASP   A 1 175 ? -9.02800  -11.41200 -22.44300 1.000 42.19160 ? 371 ASP   A CA  1 
ATOM   1320 C C   . ASP   A 1 175 ? -7.94300  -10.87500 -21.51100 1.000 38.46555 ? 371 ASP   A C   1 
ATOM   1321 O O   . ASP   A 1 175 ? -7.30400  -11.62100 -20.76200 1.000 35.04531 ? 371 ASP   A O   1 
ATOM   1322 C CB  . ASP   A 1 175 ? -10.38200 -10.72800 -22.21800 1.000 39.06335 ? 371 ASP   A CB  1 
ATOM   1323 C CG  . ASP   A 1 175 ? -10.94300 -10.94400 -20.81900 1.000 43.69411 ? 371 ASP   A CG  1 
ATOM   1324 O OD1 . ASP   A 1 175 ? -12.18300 -11.04000 -20.70800 1.000 49.56317 ? 371 ASP   A OD1 1 
ATOM   1325 O OD2 . ASP   A 1 175 ? -10.17800 -11.00300 -19.83100 1.000 44.79204 ? 371 ASP   A OD2 1 
ATOM   1326 N N   . ASP   A 1 176 ? -7.73500  -9.55600  -21.56500 1.000 36.50435 ? 372 ASP   A N   1 
ATOM   1327 C CA  . ASP   A 1 176 ? -6.64400  -8.93900  -20.81600 1.000 34.10640 ? 372 ASP   A CA  1 
ATOM   1328 C C   . ASP   A 1 176 ? -6.83000  -9.09700  -19.31300 1.000 34.45987 ? 372 ASP   A C   1 
ATOM   1329 O O   . ASP   A 1 176 ? -5.84900  -9.21300  -18.56900 1.000 33.28205 ? 372 ASP   A O   1 
ATOM   1330 C CB  . ASP   A 1 176 ? -6.53300  -7.45700  -21.17900 1.000 34.98496 ? 372 ASP   A CB  1 
ATOM   1331 C CG  . ASP   A 1 176 ? -5.89800  -7.23800  -22.53800 1.000 37.88123 ? 372 ASP   A CG  1 
ATOM   1332 O OD1 . ASP   A 1 176 ? -4.77200  -7.73300  -22.75100 1.000 36.86020 ? 372 ASP   A OD1 1 
ATOM   1333 O OD2 . ASP   A 1 176 ? -6.52800  -6.57800  -23.39000 1.000 39.48950 ? 372 ASP   A OD2 1 
ATOM   1334 N N   . SER   A 1 177 ? -8.07800  -9.07100  -18.84200 1.000 32.47828 ? 373 SER   A N   1 
ATOM   1335 C CA  . SER   A 1 177 ? -8.31200  -9.26900  -17.41600 1.000 35.27931 ? 373 SER   A CA  1 
ATOM   1336 C C   . SER   A 1 177 ? -7.81700  -10.64100 -16.96900 1.000 34.45883 ? 373 SER   A C   1 
ATOM   1337 O O   . SER   A 1 177 ? -7.20300  -10.76500 -15.90200 1.000 34.04740 ? 373 SER   A O   1 
ATOM   1338 C CB  . SER   A 1 177 ? -9.79400  -9.08100  -17.09300 1.000 33.07905 ? 373 SER   A CB  1 
ATOM   1339 O OG  . SER   A 1 177 ? -10.57100 -10.15300 -17.60100 1.000 42.40932 ? 373 SER   A OG  1 
ATOM   1340 N N   . ASP   A 1 178 ? -8.05100  -11.68000 -17.78300 1.000 34.85681 ? 374 ASP   A N   1 
ATOM   1341 C CA  . ASP   A 1 178 ? -7.50800  -13.00600 -17.47400 1.000 37.22049 ? 374 ASP   A CA  1 
ATOM   1342 C C   . ASP   A 1 178 ? -5.98600  -12.99900 -17.52000 1.000 34.45414 ? 374 ASP   A C   1 
ATOM   1343 O O   . ASP   A 1 178 ? -5.32300  -13.49400 -16.60000 1.000 31.36164 ? 374 ASP   A O   1 
ATOM   1344 C CB  . ASP   A 1 178 ? -8.03300  -14.06500 -18.45200 1.000 36.89876 ? 374 ASP   A CB  1 
ATOM   1345 C CG  . ASP   A 1 178 ? -9.53900  -14.04600 -18.60700 1.000 40.43470 ? 374 ASP   A CG  1 
ATOM   1346 O OD1 . ASP   A 1 178 ? -10.25300 -13.93400 -17.58800 1.000 38.52822 ? 374 ASP   A OD1 1 
ATOM   1347 O OD2 . ASP   A 1 178 ? -10.00600 -14.17200 -19.75800 1.000 42.20334 ? 374 ASP   A OD2 1 
ATOM   1348 N N   . ILE   A 1 179 ? -5.41700  -12.45600 -18.60100 1.000 34.45928 ? 375 ILE   A N   1 
ATOM   1349 C CA  . ILE   A 1 179 ? -3.97600  -12.54100 -18.81200 1.000 31.89123 ? 375 ILE   A CA  1 
ATOM   1350 C C   . ILE   A 1 179 ? -3.22200  -11.79500 -17.71900 1.000 31.24651 ? 375 ILE   A C   1 
ATOM   1351 O O   . ILE   A 1 179 ? -2.13400  -12.21600 -17.30800 1.000 29.83330 ? 375 ILE   A O   1 
ATOM   1352 C CB  . ILE   A 1 179 ? -3.62900  -12.02600 -20.22500 1.000 32.10929 ? 375 ILE   A CB  1 
ATOM   1353 C CG1 . ILE   A 1 179 ? -4.28200  -12.92000 -21.28800 1.000 37.28330 ? 375 ILE   A CG1 1 
ATOM   1354 C CG2 . ILE   A 1 179 ? -2.12900  -11.97400 -20.45000 1.000 30.03180 ? 375 ILE   A CG2 1 
ATOM   1355 C CD1 . ILE   A 1 179 ? -4.45800  -12.24000 -22.64000 1.000 36.01961 ? 375 ILE   A CD1 1 
ATOM   1356 N N   . SER   A 1 180 ? -3.78600  -10.69300 -17.21100 1.000 35.26356 ? 376 SER   A N   1 
ATOM   1357 C CA  . SER   A 1 180 ? -3.11500  -9.96600  -16.13900 1.000 32.84280 ? 376 SER   A CA  1 
ATOM   1358 C C   . SER   A 1 180 ? -2.92800  -10.85100 -14.91200 1.000 33.51761 ? 376 SER   A C   1 
ATOM   1359 O O   . SER   A 1 180 ? -1.84500  -10.87600 -14.31300 1.000 32.05084 ? 376 SER   A O   1 
ATOM   1360 C CB  . SER   A 1 180 ? -3.89900  -8.70200  -15.78000 1.000 34.91609 ? 376 SER   A CB  1 
ATOM   1361 O OG  . SER   A 1 180 ? -5.12900  -9.00700  -15.15100 1.000 32.91379 ? 376 SER   A OG  1 
ATOM   1362 N N   . LEU   A 1 181 ? -3.96900  -11.59700 -14.53200 1.000 27.48512 ? 377 LEU   A N   1 
ATOM   1363 C CA  . LEU   A 1 181 ? -3.84900  -12.49300 -13.38800 1.000 34.33822 ? 377 LEU   A CA  1 
ATOM   1364 C C   . LEU   A 1 181 ? -2.91200  -13.65400 -13.69800 1.000 31.70946 ? 377 LEU   A C   1 
ATOM   1365 O O   . LEU   A 1 181 ? -2.13000  -14.07700 -12.83800 1.000 31.78874 ? 377 LEU   A O   1 
ATOM   1366 C CB  . LEU   A 1 181 ? -5.23000  -13.00600 -12.97800 1.000 34.18530 ? 377 LEU   A CB  1 
ATOM   1367 C CG  . LEU   A 1 181 ? -6.25500  -11.92200 -12.62100 1.000 34.91258 ? 377 LEU   A CG  1 
ATOM   1368 C CD1 . LEU   A 1 181 ? -7.66100  -12.50300 -12.55600 1.000 34.41428 ? 377 LEU   A CD1 1 
ATOM   1369 C CD2 . LEU   A 1 181 ? -5.88400  -11.26600 -11.30500 1.000 37.14754 ? 377 LEU   A CD2 1 
ATOM   1370 N N   . PHE   A 1 182 ? -2.99400  -14.18800 -14.91700 1.000 32.26421 ? 378 PHE   A N   1 
ATOM   1371 C CA  . PHE   A 1 182 ? -2.08900  -15.24700 -15.35200 1.000 31.00942 ? 378 PHE   A CA  1 
ATOM   1372 C C   . PHE   A 1 182 ? -0.63300  -14.82100 -15.20100 1.000 30.30132 ? 378 PHE   A C   1 
ATOM   1373 O O   . PHE   A 1 182 ? 0.18600   -15.54900 -14.63000 1.000 30.79344 ? 378 PHE   A O   1 
ATOM   1374 C CB  . PHE   A 1 182 ? -2.40900  -15.61400 -16.80600 1.000 34.66022 ? 378 PHE   A CB  1 
ATOM   1375 C CG  . PHE   A 1 182 ? -1.69300  -16.83100 -17.30800 1.000 31.88197 ? 378 PHE   A CG  1 
ATOM   1376 C CD1 . PHE   A 1 182 ? -2.09900  -18.10100 -16.92500 1.000 34.90005 ? 378 PHE   A CD1 1 
ATOM   1377 C CD2 . PHE   A 1 182 ? -0.63300  -16.71000 -18.19000 1.000 34.86170 ? 378 PHE   A CD2 1 
ATOM   1378 C CE1 . PHE   A 1 182 ? -1.44100  -19.22700 -17.39700 1.000 36.73102 ? 378 PHE   A CE1 1 
ATOM   1379 C CE2 . PHE   A 1 182 ? 0.02700   -17.83300 -18.67000 1.000 35.54315 ? 378 PHE   A CE2 1 
ATOM   1380 C CZ  . PHE   A 1 182 ? -0.37900  -19.09100 -18.27200 1.000 36.19556 ? 378 PHE   A CZ  1 
ATOM   1381 N N   . VAL   A 1 183 ? -0.29800  -13.62500 -15.69300 1.000 28.77957 ? 379 VAL   A N   1 
ATOM   1382 C CA  . VAL   A 1 183 ? 1.07900   -13.14500 -15.62200 1.000 30.26040 ? 379 VAL   A CA  1 
ATOM   1383 C C   . VAL   A 1 183 ? 1.48000   -12.87600 -14.17400 1.000 30.64443 ? 379 VAL   A C   1 
ATOM   1384 O O   . VAL   A 1 183 ? 2.61800   -13.14300 -13.77000 1.000 32.69447 ? 379 VAL   A O   1 
ATOM   1385 C CB  . VAL   A 1 183 ? 1.24600   -11.89600 -16.50900 1.000 32.68534 ? 379 VAL   A CB  1 
ATOM   1386 C CG1 . VAL   A 1 183 ? 2.57600   -11.20800 -16.24100 1.000 32.50887 ? 379 VAL   A CG1 1 
ATOM   1387 C CG2 . VAL   A 1 183 ? 1.12400   -12.28000 -17.97900 1.000 32.61100 ? 379 VAL   A CG2 1 
ATOM   1388 N N   . ALA   A 1 184 ? 0.55400   -12.35300 -13.36800 1.000 29.74072 ? 380 ALA   A N   1 
ATOM   1389 C CA  . ALA   A 1 184 ? 0.82800   -12.18800 -11.94200 1.000 32.03573 ? 380 ALA   A CA  1 
ATOM   1390 C C   . ALA   A 1 184 ? 1.18500   -13.52300 -11.28900 1.000 32.45719 ? 380 ALA   A C   1 
ATOM   1391 O O   . ALA   A 1 184 ? 2.11200   -13.59600 -10.47500 1.000 32.39346 ? 380 ALA   A O   1 
ATOM   1392 C CB  . ALA   A 1 184 ? -0.37700  -11.55000 -11.24500 1.000 30.42701 ? 380 ALA   A CB  1 
ATOM   1393 N N   . ALA   A 1 185 ? 0.47200   -14.59500 -11.65000 1.000 29.92864 ? 381 ALA   A N   1 
ATOM   1394 C CA  . ALA   A 1 185 ? 0.76500   -15.90500 -11.07300 1.000 31.88018 ? 381 ALA   A CA  1 
ATOM   1395 C C   . ALA   A 1 185 ? 2.12300   -16.42500 -11.53600 1.000 32.43461 ? 381 ALA   A C   1 
ATOM   1396 O O   . ALA   A 1 185 ? 2.83400   -17.09100 -10.77100 1.000 38.43594 ? 381 ALA   A O   1 
ATOM   1397 C CB  . ALA   A 1 185 ? -0.34400  -16.89100 -11.42600 1.000 33.13158 ? 381 ALA   A CB  1 
ATOM   1398 N N   . ILE   A 1 186 ? 2.50200   -16.11900 -12.77800 1.000 35.72789 ? 382 ILE   A N   1 
ATOM   1399 C CA  . ILE   A 1 186 ? 3.80700   -16.52700 -13.29600 1.000 33.78889 ? 382 ILE   A CA  1 
ATOM   1400 C C   . ILE   A 1 186 ? 4.92700   -15.86400 -12.50200 1.000 37.51317 ? 382 ILE   A C   1 
ATOM   1401 O O   . ILE   A 1 186 ? 5.90100   -16.51400 -12.09900 1.000 36.77663 ? 382 ILE   A O   1 
ATOM   1402 C CB  . ILE   A 1 186 ? 3.90400   -16.20000 -14.79900 1.000 35.35188 ? 382 ILE   A CB  1 
ATOM   1403 C CG1 . ILE   A 1 186 ? 3.07700   -17.20300 -15.61500 1.000 35.66926 ? 382 ILE   A CG1 1 
ATOM   1404 C CG2 . ILE   A 1 186 ? 5.36100   -16.14500 -15.26500 1.000 35.99946 ? 382 ILE   A CG2 1 
ATOM   1405 C CD1 . ILE   A 1 186 ? 3.05700   -16.91300 -17.09800 1.000 35.70661 ? 382 ILE   A CD1 1 
ATOM   1406 N N   . ILE   A 1 187 ? 4.79400   -14.56100 -12.24200 1.000 33.15773 ? 383 ILE   A N   1 
ATOM   1407 C CA  . ILE   A 1 187 ? 5.86700   -13.83000 -11.57400 1.000 35.38788 ? 383 ILE   A CA  1 
ATOM   1408 C C   . ILE   A 1 187 ? 5.99500   -14.25700 -10.11400 1.000 39.06796 ? 383 ILE   A C   1 
ATOM   1409 O O   . ILE   A 1 187 ? 7.10800   -14.44300 -9.60400  1.000 39.41973 ? 383 ILE   A O   1 
ATOM   1410 C CB  . ILE   A 1 187 ? 5.63200   -12.31600 -11.70600 1.000 37.67286 ? 383 ILE   A CB  1 
ATOM   1411 C CG1 . ILE   A 1 187 ? 5.86100   -11.87300 -13.15400 1.000 33.36548 ? 383 ILE   A CG1 1 
ATOM   1412 C CG2 . ILE   A 1 187 ? 6.53900   -11.54000 -10.76000 1.000 35.58909 ? 383 ILE   A CG2 1 
ATOM   1413 C CD1 . ILE   A 1 187 ? 5.27400   -10.52100 -13.45300 1.000 35.30861 ? 383 ILE   A CD1 1 
ATOM   1414 N N   . CYS   A 1 188 ? 4.86900   -14.41600 -9.41700  1.000 32.74652 ? 384 CYS   A N   1 
ATOM   1415 C CA  . CYS   A 1 188 ? 4.88300   -14.70800 -7.98300  1.000 37.57223 ? 384 CYS   A CA  1 
ATOM   1416 C C   . CYS   A 1 188 ? 4.86100   -16.22100 -7.77900  1.000 41.74287 ? 384 CYS   A C   1 
ATOM   1417 O O   . CYS   A 1 188 ? 3.86600   -16.82000 -7.37700  1.000 44.39337 ? 384 CYS   A O   1 
ATOM   1418 C CB  . CYS   A 1 188 ? 3.70700   -14.03400 -7.29200  1.000 36.40366 ? 384 CYS   A CB  1 
ATOM   1419 S SG  . CYS   A 1 188 ? 3.68900   -12.25100 -7.48800  1.000 42.32352 ? 384 CYS   A SG  1 
ATOM   1420 N N   . CYS   A 1 189 ? 5.99800   -16.83600 -8.07500  1.000 42.61600 ? 385 CYS   A N   1 
ATOM   1421 C CA  . CYS   A 1 189 ? 6.13400   -18.28600 -8.10300  1.000 42.60042 ? 385 CYS   A CA  1 
ATOM   1422 C C   . CYS   A 1 189 ? 7.05000   -18.72500 -6.96800  1.000 42.58686 ? 385 CYS   A C   1 
ATOM   1423 O O   . CYS   A 1 189 ? 8.21600   -18.32200 -6.92000  1.000 42.50008 ? 385 CYS   A O   1 
ATOM   1424 C CB  . CYS   A 1 189 ? 6.68800   -18.73500 -9.45200  1.000 46.96358 ? 385 CYS   A CB  1 
ATOM   1425 S SG  . CYS   A 1 189 ? 6.52400   -20.48300 -9.78700  1.000 54.38642 ? 385 CYS   A SG  1 
ATOM   1426 N N   . GLY   A 1 190 ? 6.52800   -19.56200 -6.07300  1.000 42.47603 ? 386 GLY   A N   1 
ATOM   1427 C CA  . GLY   A 1 190 ? 7.24600   -19.96700 -4.88200  1.000 46.46469 ? 386 GLY   A CA  1 
ATOM   1428 C C   . GLY   A 1 190 ? 8.28000   -21.05800 -5.05000  1.000 48.41344 ? 386 GLY   A C   1 
ATOM   1429 O O   . GLY   A 1 190 ? 9.00300   -21.35300 -4.09300  1.000 50.26986 ? 386 GLY   A O   1 
ATOM   1430 N N   . ASP   A 1 191 ? 8.38800   -21.67200 -6.22800  1.000 45.10351 ? 387 ASP   A N   1 
ATOM   1431 C CA  . ASP   A 1 191 ? 9.33200   -22.76300 -6.43700  1.000 50.78678 ? 387 ASP   A CA  1 
ATOM   1432 C C   . ASP   A 1 191 ? 10.52400  -22.34600 -7.29200  1.000 48.07832 ? 387 ASP   A C   1 
ATOM   1433 O O   . ASP   A 1 191 ? 11.22500  -23.20600 -7.83600  1.000 53.68770 ? 387 ASP   A O   1 
ATOM   1434 C CB  . ASP   A 1 191 ? 8.62000   -23.98400 -7.03300  1.000 50.25911 ? 387 ASP   A CB  1 
ATOM   1435 C CG  . ASP   A 1 191 ? 8.43500   -23.89800 -8.54800  1.000 56.35221 ? 387 ASP   A CG  1 
ATOM   1436 O OD1 . ASP   A 1 191 ? 8.38000   -22.78000 -9.09700  1.000 56.27095 ? 387 ASP   A OD1 1 
ATOM   1437 O OD2 . ASP   A 1 191 ? 8.34500   -24.96400 -9.19300  1.000 51.95770 ? 387 ASP   A OD2 1 
ATOM   1438 N N   . ARG   A 1 192 ? 10.77400  -21.04900 -7.41800  1.000 46.26335 ? 388 ARG   A N   1 
ATOM   1439 C CA  . ARG   A 1 192 ? 11.92400  -20.60800 -8.18800  1.000 49.26432 ? 388 ARG   A CA  1 
ATOM   1440 C C   . ARG   A 1 192 ? 13.20700  -20.93300 -7.42300  1.000 50.84925 ? 388 ARG   A C   1 
ATOM   1441 O O   . ARG   A 1 192 ? 13.23700  -20.83500 -6.19300  1.000 50.91073 ? 388 ARG   A O   1 
ATOM   1442 C CB  . ARG   A 1 192 ? 11.84700  -19.10800 -8.47600  1.000 49.32580 ? 388 ARG   A CB  1 
ATOM   1443 C CG  . ARG   A 1 192 ? 10.56800  -18.65000 -9.16700  1.000 42.41886 ? 388 ARG   A CG  1 
ATOM   1444 C CD  . ARG   A 1 192 ? 10.36700  -19.32200 -10.52000 1.000 48.02987 ? 388 ARG   A CD  1 
ATOM   1445 N NE  . ARG   A 1 192 ? 9.30200   -18.67800 -11.28400 1.000 43.71787 ? 388 ARG   A NE  1 
ATOM   1446 C CZ  . ARG   A 1 192 ? 8.87700   -19.07900 -12.47600 1.000 45.95910 ? 388 ARG   A CZ  1 
ATOM   1447 N NH1 . ARG   A 1 192 ? 9.38400   -20.14700 -13.06800 1.000 40.59340 ? 388 ARG   A NH1 1 
ATOM   1448 N NH2 . ARG   A 1 192 ? 7.91800   -18.38900 -13.08800 1.000 40.42126 ? 388 ARG   A NH2 1 
ATOM   1449 N N   . PRO   A 1 193 ? 14.27400  -21.33000 -8.11500  1.000 55.71306 ? 389 PRO   A N   1 
ATOM   1450 C CA  . PRO   A 1 193 ? 15.49700  -21.74600 -7.41200  1.000 53.57639 ? 389 PRO   A CA  1 
ATOM   1451 C C   . PRO   A 1 193 ? 16.19000  -20.56300 -6.75000  1.000 58.88328 ? 389 PRO   A C   1 
ATOM   1452 O O   . PRO   A 1 193 ? 16.44300  -19.53700 -7.38600  1.000 60.17220 ? 389 PRO   A O   1 
ATOM   1453 C CB  . PRO   A 1 193 ? 16.36100  -22.34900 -8.52700  1.000 53.99835 ? 389 PRO   A CB  1 
ATOM   1454 C CG  . PRO   A 1 193 ? 15.41100  -22.61700 -9.66100  1.000 53.84646 ? 389 PRO   A CG  1 
ATOM   1455 C CD  . PRO   A 1 193 ? 14.37400  -21.54500 -9.56700  1.000 50.42123 ? 389 PRO   A CD  1 
ATOM   1456 N N   . GLY   A 1 194 ? 16.50800  -20.71800 -5.46700  1.000 53.61363 ? 390 GLY   A N   1 
ATOM   1457 C CA  . GLY   A 1 194 ? 17.22500  -19.70000 -4.73200  1.000 56.80678 ? 390 GLY   A CA  1 
ATOM   1458 C C   . GLY   A 1 194 ? 16.36800  -18.75900 -3.91400  1.000 54.48771 ? 390 GLY   A C   1 
ATOM   1459 O O   . GLY   A 1 194 ? 16.91700  -17.85900 -3.26600  1.000 53.38256 ? 390 GLY   A O   1 
ATOM   1460 N N   . LEU   A 1 195 ? 15.04700  -18.92600 -3.92500  1.000 53.88133 ? 391 LEU   A N   1 
ATOM   1461 C CA  . LEU   A 1 195 ? 14.19600  -18.09800 -3.08300  1.000 48.18721 ? 391 LEU   A CA  1 
ATOM   1462 C C   . LEU   A 1 195 ? 14.49700  -18.36100 -1.61500  1.000 56.26104 ? 391 LEU   A C   1 
ATOM   1463 O O   . LEU   A 1 195 ? 14.71700  -19.50300 -1.20300  1.000 60.52211 ? 391 LEU   A O   1 
ATOM   1464 C CB  . LEU   A 1 195 ? 12.72000  -18.38200 -3.36600  1.000 51.81630 ? 391 LEU   A CB  1 
ATOM   1465 C CG  . LEU   A 1 195 ? 12.10300  -17.78400 -4.63200  1.000 50.75045 ? 391 LEU   A CG  1 
ATOM   1466 C CD1 . LEU   A 1 195 ? 10.63600  -18.17800 -4.73200  1.000 44.07129 ? 391 LEU   A CD1 1 
ATOM   1467 C CD2 . LEU   A 1 195 ? 12.26900  -16.27200 -4.64900  1.000 46.53179 ? 391 LEU   A CD2 1 
ATOM   1468 N N   . LEU   A 1 196 ? 14.50500  -17.29500 -0.82000  1.000 51.32804 ? 392 LEU   A N   1 
ATOM   1469 C CA  . LEU   A 1 196 ? 14.65800  -17.43200 0.62100   1.000 55.31532 ? 392 LEU   A CA  1 
ATOM   1470 C C   . LEU   A 1 196 ? 13.31800  -17.42800 1.34400   1.000 54.86216 ? 392 LEU   A C   1 
ATOM   1471 O O   . LEU   A 1 196 ? 13.03400  -18.33800 2.12800   1.000 54.15522 ? 392 LEU   A O   1 
ATOM   1472 C CB  . LEU   A 1 196 ? 15.56400  -16.32000 1.16700   1.000 54.67915 ? 392 LEU   A CB  1 
ATOM   1473 C CG  . LEU   A 1 196 ? 17.05100  -16.59200 0.92400   1.000 57.91660 ? 392 LEU   A CG  1 
ATOM   1474 C CD1 . LEU   A 1 196 ? 17.88500  -15.33400 1.11500   1.000 54.09592 ? 392 LEU   A CD1 1 
ATOM   1475 C CD2 . LEU   A 1 196 ? 17.54300  -17.72300 1.82700   1.000 53.05632 ? 392 LEU   A CD2 1 
ATOM   1476 N N   . ASN   A 1 197 ? 12.47700  -16.43100 1.08600   1.000 47.96700 ? 393 ASN   A N   1 
ATOM   1477 C CA  . ASN   A 1 197 ? 11.16400  -16.35900 1.72300   1.000 47.60491 ? 393 ASN   A CA  1 
ATOM   1478 C C   . ASN   A 1 197 ? 10.13500  -17.14600 0.90600   1.000 51.19383 ? 393 ASN   A C   1 
ATOM   1479 O O   . ASN   A 1 197 ? 9.14000   -16.61500 0.40900   1.000 48.19893 ? 393 ASN   A O   1 
ATOM   1480 C CB  . ASN   A 1 197 ? 10.74700  -14.90600 1.90900   1.000 46.35448 ? 393 ASN   A CB  1 
ATOM   1481 C CG  . ASN   A 1 197 ? 9.65600   -14.74400 2.94700   1.000 46.84360 ? 393 ASN   A CG  1 
ATOM   1482 O OD1 . ASN   A 1 197 ? 9.08300   -15.72400 3.42200   1.000 48.60904 ? 393 ASN   A OD1 1 
ATOM   1483 N ND2 . ASN   A 1 197 ? 9.36500   -13.50100 3.30700   1.000 50.48683 ? 393 ASN   A ND2 1 
ATOM   1484 N N   . VAL   A 1 198 ? 10.40800  -18.45000 0.78000   1.000 48.31006 ? 394 VAL   A N   1 
ATOM   1485 C CA  . VAL   A 1 198 ? 9.53900   -19.33700 0.01000   1.000 48.55290 ? 394 VAL   A CA  1 
ATOM   1486 C C   . VAL   A 1 198 ? 8.14000   -19.36300 0.60800   1.000 50.07241 ? 394 VAL   A C   1 
ATOM   1487 O O   . VAL   A 1 198 ? 7.13800   -19.31700 -0.11700  1.000 50.48278 ? 394 VAL   A O   1 
ATOM   1488 C CB  . VAL   A 1 198 ? 10.14600  -20.75400 -0.06000  1.000 51.90875 ? 394 VAL   A CB  1 
ATOM   1489 C CG1 . VAL   A 1 198 ? 9.20100   -21.71000 -0.77200  1.000 47.31713 ? 394 VAL   A CG1 1 
ATOM   1490 C CG2 . VAL   A 1 198 ? 11.49500  -20.72700 -0.74800  1.000 52.69867 ? 394 VAL   A CG2 1 
ATOM   1491 N N   . GLY   A 1 199 ? 8.04900   -19.43600 1.93700   1.000 51.92163 ? 395 GLY   A N   1 
ATOM   1492 C CA  . GLY   A 1 199 ? 6.74700   -19.53500 2.57800   1.000 53.02825 ? 395 GLY   A CA  1 
ATOM   1493 C C   . GLY   A 1 199 ? 5.83200   -18.37700 2.23400   1.000 52.14015 ? 395 GLY   A C   1 
ATOM   1494 O O   . GLY   A 1 199 ? 4.66300   -18.57800 1.89200   1.000 52.44143 ? 395 GLY   A O   1 
ATOM   1495 N N   . HIS   A 1 200 ? 6.35700   -17.15000 2.29200   1.000 47.59860 ? 396 HIS   A N   1 
ATOM   1496 C CA  . HIS   A 1 200 ? 5.52400   -15.98100 2.02600   1.000 48.32105 ? 396 HIS   A CA  1 
ATOM   1497 C C   . HIS   A 1 200 ? 5.14500   -15.88500 0.55100   1.000 49.27867 ? 396 HIS   A C   1 
ATOM   1498 O O   . HIS   A 1 200 ? 3.98700   -15.60500 0.22200   1.000 47.10823 ? 396 HIS   A O   1 
ATOM   1499 C CB  . HIS   A 1 200 ? 6.24000   -14.71000 2.47200   1.000 49.12086 ? 396 HIS   A CB  1 
ATOM   1500 C CG  . HIS   A 1 200 ? 5.43800   -13.46700 2.26100   1.000 52.80450 ? 396 HIS   A CG  1 
ATOM   1501 N ND1 . HIS   A 1 200 ? 5.82900   -12.46500 1.39900   1.000 55.75643 ? 396 HIS   A ND1 1 
ATOM   1502 C CD2 . HIS   A 1 200 ? 4.26200   -13.06500 2.79700   1.000 56.35605 ? 396 HIS   A CD2 1 
ATOM   1503 C CE1 . HIS   A 1 200 ? 4.92800   -11.49800 1.41400   1.000 58.12279 ? 396 HIS   A CE1 1 
ATOM   1504 N NE2 . HIS   A 1 200 ? 3.96800   -11.83700 2.25500   1.000 60.26196 ? 396 HIS   A NE2 1 
ATOM   1505 N N   . ILE   A 1 201 ? 6.10800   -16.09300 -0.35000  1.000 45.40263 ? 397 ILE   A N   1 
ATOM   1506 C CA  . ILE   A 1 201 ? 5.80900   -16.05000 -1.78200  1.000 43.80831 ? 397 ILE   A CA  1 
ATOM   1507 C C   . ILE   A 1 201 ? 4.80300   -17.13300 -2.14800  1.000 40.16111 ? 397 ILE   A C   1 
ATOM   1508 O O   . ILE   A 1 201 ? 3.91900   -16.92200 -2.98700  1.000 40.94741 ? 397 ILE   A O   1 
ATOM   1509 C CB  . ILE   A 1 201 ? 7.11000   -16.16700 -2.59900  1.000 41.39496 ? 397 ILE   A CB  1 
ATOM   1510 C CG1 . ILE   A 1 201 ? 8.02800   -14.98400 -2.27700  1.000 43.04915 ? 397 ILE   A CG1 1 
ATOM   1511 C CG2 . ILE   A 1 201 ? 6.82100   -16.25300 -4.08700  1.000 39.72755 ? 397 ILE   A CG2 1 
ATOM   1512 C CD1 . ILE   A 1 201 ? 9.45300   -15.16400 -2.72200  1.000 43.32727 ? 397 ILE   A CD1 1 
ATOM   1513 N N   . GLU   A 1 202 ? 4.90600   -18.30100 -1.50800  1.000 42.58011 ? 398 GLU   A N   1 
ATOM   1514 C CA  . GLU   A 1 202 ? 3.91400   -19.35000 -1.71900  1.000 46.39811 ? 398 GLU   A CA  1 
ATOM   1515 C C   . GLU   A 1 202 ? 2.51700   -18.87100 -1.33600  1.000 45.32210 ? 398 GLU   A C   1 
ATOM   1516 O O   . GLU   A 1 202 ? 1.54300   -19.14700 -2.04600  1.000 46.47440 ? 398 GLU   A O   1 
ATOM   1517 C CB  . GLU   A 1 202 ? 4.29800   -20.60300 -0.93000  1.000 46.50498 ? 398 GLU   A CB  1 
ATOM   1518 C CG  . GLU   A 1 202 ? 5.05900   -21.63400 -1.74700  1.000 50.85775 ? 398 GLU   A CG  1 
ATOM   1519 C CD  . GLU   A 1 202 ? 5.52400   -22.82000 -0.92200  1.000 58.39200 ? 398 GLU   A CD  1 
ATOM   1520 O OE1 . GLU   A 1 202 ? 4.97700   -23.03200 0.18300   1.000 59.64007 ? 398 GLU   A OE1 1 
ATOM   1521 O OE2 . GLU   A 1 202 ? 6.43100   -23.54600 -1.38300  1.000 61.41313 ? 398 GLU   A OE2 1 
ATOM   1522 N N   . LYS   A 1 203 ? 2.39700   -18.13700 -0.22300  1.000 44.01937 ? 399 LYS   A N   1 
ATOM   1523 C CA  . LYS   A 1 203 ? 1.09300   -17.58900 0.13600   1.000 46.01803 ? 399 LYS   A CA  1 
ATOM   1524 C C   . LYS   A 1 203 ? 0.66100   -16.48100 -0.81600  1.000 43.30984 ? 399 LYS   A C   1 
ATOM   1525 O O   . LYS   A 1 203 ? -0.53900  -16.33100 -1.07200  1.000 40.45296 ? 399 LYS   A O   1 
ATOM   1526 C CB  . LYS   A 1 203 ? 1.07300   -17.06600 1.57800   1.000 49.85382 ? 399 LYS   A CB  1 
ATOM   1527 C CG  . LYS   A 1 203 ? 1.41500   -18.07500 2.66900   1.000 53.41089 ? 399 LYS   A CG  1 
ATOM   1528 C CD  . LYS   A 1 203 ? 1.85300   -17.35400 3.94500   1.000 64.73193 ? 399 LYS   A CD  1 
ATOM   1529 C CE  . LYS   A 1 203 ? 3.22200   -17.78300 4.43800   1.000 65.90193 ? 399 LYS   A CE  1 
ATOM   1530 N NZ  . LYS   A 1 203 ? 3.47100   -17.34400 5.83800   1.000 63.98268 ? 399 LYS   A NZ  1 
ATOM   1531 N N   . MET   A 1 204 ? 1.60600   -15.69100 -1.33500  1.000 41.23477 ? 400 MET   A N   1 
ATOM   1532 C CA  . MET   A 1 204 ? 1.25100   -14.70600 -2.35400  1.000 38.49856 ? 400 MET   A CA  1 
ATOM   1533 C C   . MET   A 1 204 ? 0.65500   -15.38200 -3.58100  1.000 42.39527 ? 400 MET   A C   1 
ATOM   1534 O O   . MET   A 1 204 ? -0.35400  -14.91900 -4.12700  1.000 40.24832 ? 400 MET   A O   1 
ATOM   1535 C CB  . MET   A 1 204 ? 2.47000   -13.87300 -2.76400  1.000 37.79248 ? 400 MET   A CB  1 
ATOM   1536 C CG  . MET   A 1 204 ? 3.17400   -13.12600 -1.64100  1.000 48.12240 ? 400 MET   A CG  1 
ATOM   1537 S SD  . MET   A 1 204 ? 4.14200   -11.72600 -2.26600  1.000 53.14184 ? 400 MET   A SD  1 
ATOM   1538 C CE  . MET   A 1 204 ? 3.46800   -11.52600 -3.91300  1.000 42.78474 ? 400 MET   A CE  1 
ATOM   1539 N N   . GLN   A 1 205 ? 1.26700   -16.47800 -4.03600  1.000 37.88268 ? 401 GLN   A N   1 
ATOM   1540 C CA  . GLN   A 1 205 ? 0.74900   -17.14000 -5.22800  1.000 39.43307 ? 401 GLN   A CA  1 
ATOM   1541 C C   . GLN   A 1 205 ? -0.59200  -17.80100 -4.95800  1.000 42.34309 ? 401 GLN   A C   1 
ATOM   1542 O O   . GLN   A 1 205 ? -1.46300  -17.82100 -5.83800  1.000 36.13385 ? 401 GLN   A O   1 
ATOM   1543 C CB  . GLN   A 1 205 ? 1.74100   -18.17600 -5.74400  1.000 39.87110 ? 401 GLN   A CB  1 
ATOM   1544 C CG  . GLN   A 1 205 ? 1.30400   -18.78800 -7.06700  1.000 48.31655 ? 401 GLN   A CG  1 
ATOM   1545 C CD  . GLN   A 1 205 ? 2.31800   -19.74700 -7.63600  1.000 52.04534 ? 401 GLN   A CD  1 
ATOM   1546 O OE1 . GLN   A 1 205 ? 2.87400   -20.58500 -6.92200  1.000 51.38824 ? 401 GLN   A OE1 1 
ATOM   1547 N NE2 . GLN   A 1 205 ? 2.57700   -19.62300 -8.93600  1.000 50.56927 ? 401 GLN   A NE2 1 
ATOM   1548 N N   . GLU   A 1 206 ? -0.77100  -18.34800 -3.75400  1.000 38.64831 ? 402 GLU   A N   1 
ATOM   1549 C CA  . GLU   A 1 206 ? -2.04700  -18.95000 -3.39300  1.000 44.07396 ? 402 GLU   A CA  1 
ATOM   1550 C C   . GLU   A 1 206 ? -3.18300  -17.94700 -3.53800  1.000 38.77104 ? 402 GLU   A C   1 
ATOM   1551 O O   . GLU   A 1 206 ? -4.25100  -18.27800 -4.06600  1.000 38.00658 ? 402 GLU   A O   1 
ATOM   1552 C CB  . GLU   A 1 206 ? -1.97500  -19.48800 -1.96400  1.000 45.31573 ? 402 GLU   A CB  1 
ATOM   1553 C CG  . GLU   A 1 206 ? -2.88000  -20.66800 -1.67800  1.000 53.16343 ? 402 GLU   A CG  1 
ATOM   1554 C CD  . GLU   A 1 206 ? -2.62700  -21.26300 -0.30000  1.000 57.78588 ? 402 GLU   A CD  1 
ATOM   1555 O OE1 . GLU   A 1 206 ? -3.24500  -22.29700 0.02900   1.000 63.03193 ? 402 GLU   A OE1 1 
ATOM   1556 O OE2 . GLU   A 1 206 ? -1.81100  -20.69100 0.45400   1.000 54.48561 ? 402 GLU   A OE2 1 
ATOM   1557 N N   . GLY   A 1 207 ? -2.96500  -16.70900 -3.08600  1.000 39.65353 ? 403 GLY   A N   1 
ATOM   1558 C CA  . GLY   A 1 207 ? -3.98200  -15.68300 -3.25100  1.000 36.45824 ? 403 GLY   A CA  1 
ATOM   1559 C C   . GLY   A 1 207 ? -4.25200  -15.35000 -4.70700  1.000 34.46759 ? 403 GLY   A C   1 
ATOM   1560 O O   . GLY   A 1 207 ? -5.40600  -15.23100 -5.12500  1.000 35.50154 ? 403 GLY   A O   1 
ATOM   1561 N N   . ILE   A 1 208 ? -3.18700  -15.18800 -5.50200  1.000 32.58785 ? 404 ILE   A N   1 
ATOM   1562 C CA  . ILE   A 1 208 ? -3.36200  -14.82000 -6.90700  1.000 33.53277 ? 404 ILE   A CA  1 
ATOM   1563 C C   . ILE   A 1 208 ? -4.05500  -15.93800 -7.67200  1.000 34.17066 ? 404 ILE   A C   1 
ATOM   1564 O O   . ILE   A 1 208 ? -4.96900  -15.69100 -8.46700  1.000 32.14801 ? 404 ILE   A O   1 
ATOM   1565 C CB  . ILE   A 1 208 ? -2.00900  -14.45600 -7.54800  1.000 35.45240 ? 404 ILE   A CB  1 
ATOM   1566 C CG1 . ILE   A 1 208 ? -1.48800  -13.12800 -6.99500  1.000 36.64236 ? 404 ILE   A CG1 1 
ATOM   1567 C CG2 . ILE   A 1 208 ? -2.12800  -14.39800 -9.08300  1.000 34.48331 ? 404 ILE   A CG2 1 
ATOM   1568 C CD1 . ILE   A 1 208 ? 0.00400   -12.92500 -7.18700  1.000 38.58963 ? 404 ILE   A CD1 1 
ATOM   1569 N N   . VAL   A 1 209 ? -3.62800  -17.18300 -7.45100  1.000 32.61126 ? 405 VAL   A N   1 
ATOM   1570 C CA  . VAL   A 1 209 ? -4.23600  -18.31100 -8.14900  1.000 34.99763 ? 405 VAL   A CA  1 
ATOM   1571 C C   . VAL   A 1 209 ? -5.69800  -18.45300 -7.74800  1.000 35.29356 ? 405 VAL   A C   1 
ATOM   1572 O O   . VAL   A 1 209 ? -6.56300  -18.74900 -8.58300  1.000 33.99580 ? 405 VAL   A O   1 
ATOM   1573 C CB  . VAL   A 1 209 ? -3.43000  -19.59700 -7.87700  1.000 36.74471 ? 405 VAL   A CB  1 
ATOM   1574 C CG1 . VAL   A 1 209 ? -4.19500  -20.82900 -8.33000  1.000 38.77456 ? 405 VAL   A CG1 1 
ATOM   1575 C CG2 . VAL   A 1 209 ? -2.07800  -19.52400 -8.57700  1.000 34.79282 ? 405 VAL   A CG2 1 
ATOM   1576 N N   . HIS   A 1 210 ? -5.99800  -18.21400 -6.46900  1.000 37.84679 ? 406 HIS   A N   1 
ATOM   1577 C CA  . HIS   A 1 210 ? -7.37500  -18.25700 -5.98500  1.000 38.23753 ? 406 HIS   A CA  1 
ATOM   1578 C C   . HIS   A 1 210 ? -8.26000  -17.27900 -6.75000  1.000 36.24593 ? 406 HIS   A C   1 
ATOM   1579 O O   . HIS   A 1 210 ? -9.34000  -17.64400 -7.22800  1.000 37.81031 ? 406 HIS   A O   1 
ATOM   1580 C CB  . HIS   A 1 210 ? -7.38900  -17.94800 -4.48500  1.000 37.18364 ? 406 HIS   A CB  1 
ATOM   1581 C CG  . HIS   A 1 210 ? -8.74200  -18.03800 -3.84700  1.000 47.45912 ? 406 HIS   A CG  1 
ATOM   1582 N ND1 . HIS   A 1 210 ? -9.86900  -18.44900 -4.52700  1.000 49.37158 ? 406 HIS   A ND1 1 
ATOM   1583 C CD2 . HIS   A 1 210 ? -9.14500  -17.77100 -2.58200  1.000 44.28325 ? 406 HIS   A CD2 1 
ATOM   1584 C CE1 . HIS   A 1 210 ? -10.90600 -18.42900 -3.70900  1.000 48.55331 ? 406 HIS   A CE1 1 
ATOM   1585 N NE2 . HIS   A 1 210 ? -10.49400 -18.02000 -2.52300  1.000 45.96733 ? 406 HIS   A NE2 1 
ATOM   1586 N N   . VAL   A 1 211 ? -7.81500  -16.02800 -6.87800  1.000 37.17540 ? 407 VAL   A N   1 
ATOM   1587 C CA  . VAL   A 1 211 ? -8.63700  -15.02500 -7.54500  1.000 37.43795 ? 407 VAL   A CA  1 
ATOM   1588 C C   . VAL   A 1 211 ? -8.74300  -15.32000 -9.03800  1.000 36.60947 ? 407 VAL   A C   1 
ATOM   1589 O O   . VAL   A 1 211 ? -9.79100  -15.08700 -9.65900  1.000 37.57148 ? 407 VAL   A O   1 
ATOM   1590 C CB  . VAL   A 1 211 ? -8.07700  -13.61900 -7.27700  1.000 42.76403 ? 407 VAL   A CB  1 
ATOM   1591 C CG1 . VAL   A 1 211 ? -8.87800  -12.60900 -8.03200  1.000 47.53864 ? 407 VAL   A CG1 1 
ATOM   1592 C CG2 . VAL   A 1 211 ? -8.11700  -13.31200 -5.78700  1.000 46.34757 ? 407 VAL   A CG2 1 
ATOM   1593 N N   . LEU   A 1 212 ? -7.66500  -15.83600 -9.63800  1.000 33.59756 ? 408 LEU   A N   1 
ATOM   1594 C CA  . LEU   A 1 212 ? -7.73100  -16.27200 -11.03100 1.000 37.75553 ? 408 LEU   A CA  1 
ATOM   1595 C C   . LEU   A 1 212 ? -8.83100  -17.30800 -11.22200 1.000 37.29364 ? 408 LEU   A C   1 
ATOM   1596 O O   . LEU   A 1 212 ? -9.66600  -17.18700 -12.12600 1.000 35.62321 ? 408 LEU   A O   1 
ATOM   1597 C CB  . LEU   A 1 212 ? -6.38000  -16.84100 -11.47000 1.000 36.64421 ? 408 LEU   A CB  1 
ATOM   1598 C CG  . LEU   A 1 212 ? -6.31600  -17.47500 -12.86400 1.000 34.80222 ? 408 LEU   A CG  1 
ATOM   1599 C CD1 . LEU   A 1 212 ? -6.62200  -16.44500 -13.95100 1.000 26.91770 ? 408 LEU   A CD1 1 
ATOM   1600 C CD2 . LEU   A 1 212 ? -4.95500  -18.10200 -13.09400 1.000 32.70438 ? 408 LEU   A CD2 1 
ATOM   1601 N N   . ARG   A 1 213 ? -8.84100  -18.33700 -10.37000 1.000 33.30814 ? 409 ARG   A N   1 
ATOM   1602 C CA  . ARG   A 1 213 ? -9.88500  -19.35600 -10.40700 1.000 39.35776 ? 409 ARG   A CA  1 
ATOM   1603 C C   . ARG   A 1 213 ? -11.27800 -18.73500 -10.35400 1.000 38.37088 ? 409 ARG   A C   1 
ATOM   1604 O O   . ARG   A 1 213 ? -12.13900 -19.03700 -11.18900 1.000 40.43628 ? 409 ARG   A O   1 
ATOM   1605 C CB  . ARG   A 1 213 ? -9.68500  -20.33300 -9.24400  1.000 41.21571 ? 409 ARG   A CB  1 
ATOM   1606 C CG  . ARG   A 1 213 ? -10.86900 -21.23500 -8.98300  1.000 48.02667 ? 409 ARG   A CG  1 
ATOM   1607 C CD  . ARG   A 1 213 ? -10.44800 -22.48300 -8.22600  1.000 51.50849 ? 409 ARG   A CD  1 
ATOM   1608 N NE  . ARG   A 1 213 ? -9.97300  -22.21700 -6.87200  1.000 47.40904 ? 409 ARG   A NE  1 
ATOM   1609 C CZ  . ARG   A 1 213 ? -10.76400 -21.93700 -5.84500  1.000 54.55199 ? 409 ARG   A CZ  1 
ATOM   1610 N NH1 . ARG   A 1 213 ? -12.07700 -21.85500 -5.98600  1.000 55.94870 ? 409 ARG   A NH1 1 
ATOM   1611 N NH2 . ARG   A 1 213 ? -10.22400 -21.73900 -4.64500  1.000 53.75997 ? 409 ARG   A NH2 1 
ATOM   1612 N N   . LEU   A 1 214 ? -11.51500 -17.86400 -9.36900  1.000 36.53492 ? 410 LEU   A N   1 
ATOM   1613 C CA  . LEU   A 1 214 ? -12.80700 -17.19100 -9.25800  1.000 41.42884 ? 410 LEU   A CA  1 
ATOM   1614 C C   . LEU   A 1 214 ? -13.10900 -16.36900 -10.50300 1.000 39.88458 ? 410 LEU   A C   1 
ATOM   1615 O O   . LEU   A 1 214 ? -14.23100 -16.39900 -11.01900 1.000 40.94160 ? 410 LEU   A O   1 
ATOM   1616 C CB  . LEU   A 1 214 ? -12.82800 -16.29700 -8.01600  1.000 38.98520 ? 410 LEU   A CB  1 
ATOM   1617 C CG  . LEU   A 1 214 ? -12.90800 -16.96500 -6.64500  1.000 46.41481 ? 410 LEU   A CG  1 
ATOM   1618 C CD1 . LEU   A 1 214 ? -12.76500 -15.92200 -5.54500  1.000 48.17192 ? 410 LEU   A CD1 1 
ATOM   1619 C CD2 . LEU   A 1 214 ? -14.21600 -17.72900 -6.49500  1.000 47.22977 ? 410 LEU   A CD2 1 
ATOM   1620 N N   . HIS   A 1 215 ? -12.11500 -15.63300 -11.00400 1.000 38.70413 ? 411 HIS   A N   1 
ATOM   1621 C CA  . HIS   A 1 215 ? -12.34100 -14.79100 -12.17300 1.000 41.58718 ? 411 HIS   A CA  1 
ATOM   1622 C C   . HIS   A 1 215 ? -12.70100 -15.61800 -13.40100 1.000 43.63959 ? 411 HIS   A C   1 
ATOM   1623 O O   . HIS   A 1 215 ? -13.63300 -15.26900 -14.13500 1.000 43.01420 ? 411 HIS   A O   1 
ATOM   1624 C CB  . HIS   A 1 215 ? -11.10900 -13.93000 -12.44600 1.000 41.42065 ? 411 HIS   A CB  1 
ATOM   1625 C CG  . HIS   A 1 215 ? -11.28000 -12.97900 -13.58900 1.000 43.08526 ? 411 HIS   A CG  1 
ATOM   1626 N ND1 . HIS   A 1 215 ? -12.09300 -11.86800 -13.52100 1.000 44.88842 ? 411 HIS   A ND1 1 
ATOM   1627 C CD2 . HIS   A 1 215 ? -10.73600 -12.97100 -14.82900 1.000 44.85141 ? 411 HIS   A CD2 1 
ATOM   1628 C CE1 . HIS   A 1 215 ? -12.04500 -11.21800 -14.67000 1.000 41.40604 ? 411 HIS   A CE1 1 
ATOM   1629 N NE2 . HIS   A 1 215 ? -11.22900 -11.86600 -15.48100 1.000 42.82951 ? 411 HIS   A NE2 1 
ATOM   1630 N N   . LEU   A 1 216 ? -11.97900 -16.71700 -13.64300 1.000 39.97860 ? 412 LEU   A N   1 
ATOM   1631 C CA  . LEU   A 1 216 ? -12.27900 -17.55600 -14.80100 1.000 45.01474 ? 412 LEU   A CA  1 
ATOM   1632 C C   . LEU   A 1 216 ? -13.68700 -18.12700 -14.72900 1.000 45.52224 ? 412 LEU   A C   1 
ATOM   1633 O O   . LEU   A 1 216 ? -14.33700 -18.32100 -15.76300 1.000 43.85099 ? 412 LEU   A O   1 
ATOM   1634 C CB  . LEU   A 1 216 ? -11.26500 -18.69600 -14.91000 1.000 39.74682 ? 412 LEU   A CB  1 
ATOM   1635 C CG  . LEU   A 1 216 ? -9.81700  -18.31800 -15.22200 1.000 41.07637 ? 412 LEU   A CG  1 
ATOM   1636 C CD1 . LEU   A 1 216 ? -8.94100  -19.56300 -15.22700 1.000 41.09769 ? 412 LEU   A CD1 1 
ATOM   1637 C CD2 . LEU   A 1 216 ? -9.71900  -17.57600 -16.55400 1.000 38.43852 ? 412 LEU   A CD2 1 
ATOM   1638 N N   . GLN   A 1 217 ? -14.16800 -18.39900 -13.52000 1.000 43.54510 ? 413 GLN   A N   1 
ATOM   1639 C CA  . GLN   A 1 217 ? -15.48700 -18.99700 -13.34800 1.000 51.72730 ? 413 GLN   A CA  1 
ATOM   1640 C C   . GLN   A 1 217 ? -16.58700 -18.03700 -13.79400 1.000 52.39057 ? 413 GLN   A C   1 
ATOM   1641 O O   . GLN   A 1 217 ? -17.57600 -18.45600 -14.40400 1.000 51.79053 ? 413 GLN   A O   1 
ATOM   1642 C CB  . GLN   A 1 217 ? -15.65300 -19.40800 -11.88200 1.000 49.38711 ? 413 GLN   A CB  1 
ATOM   1643 C CG  . GLN   A 1 217 ? -17.05400 -19.72500 -11.41400 1.000 54.37292 ? 413 GLN   A CG  1 
ATOM   1644 C CD  . GLN   A 1 217 ? -17.05800 -20.25700 -9.99100  1.000 66.45494 ? 413 GLN   A CD  1 
ATOM   1645 O OE1 . GLN   A 1 217 ? -16.02400 -20.69600 -9.48000  1.000 63.78568 ? 413 GLN   A OE1 1 
ATOM   1646 N NE2 . GLN   A 1 217 ? -18.21600 -20.21500 -9.34000  1.000 67.91610 ? 413 GLN   A NE2 1 
ATOM   1647 N N   . SER   A 1 218 ? -16.41800 -16.74000 -13.52200 1.000 50.07892 ? 414 SER   A N   1 
ATOM   1648 C CA  . SER   A 1 218 ? -17.41500 -15.74100 -13.89200 1.000 53.37325 ? 414 SER   A CA  1 
ATOM   1649 C C   . SER   A 1 218 ? -17.15700 -15.11100 -15.25500 1.000 53.48188 ? 414 SER   A C   1 
ATOM   1650 O O   . SER   A 1 218 ? -18.11300 -14.72800 -15.94000 1.000 54.86166 ? 414 SER   A O   1 
ATOM   1651 C CB  . SER   A 1 218 ? -17.47400 -14.64100 -12.83000 1.000 52.48250 ? 414 SER   A CB  1 
ATOM   1652 O OG  . SER   A 1 218 ? -16.23800 -13.95500 -12.74200 1.000 52.06486 ? 414 SER   A OG  1 
ATOM   1653 N N   . ASN   A 1 219 ? -15.89300 -14.98800 -15.66800 1.000 50.87185 ? 415 ASN   A N   1 
ATOM   1654 C CA  . ASN   A 1 219 ? -15.58400 -14.38800 -16.96000 1.000 49.34457 ? 415 ASN   A CA  1 
ATOM   1655 C C   . ASN   A 1 219 ? -15.69200 -15.37900 -18.11500 1.000 50.01102 ? 415 ASN   A C   1 
ATOM   1656 O O   . ASN   A 1 219 ? -15.86700 -14.95200 -19.26200 1.000 48.65293 ? 415 ASN   A O   1 
ATOM   1657 C CB  . ASN   A 1 219 ? -14.18300 -13.77300 -16.93400 1.000 46.70086 ? 415 ASN   A CB  1 
ATOM   1658 C CG  . ASN   A 1 219 ? -13.97300 -12.75400 -18.04100 1.000 49.84170 ? 415 ASN   A CG  1 
ATOM   1659 O OD1 . ASN   A 1 219 ? -14.88800 -12.00800 -18.39900 1.000 46.72263 ? 415 ASN   A OD1 1 
ATOM   1660 N ND2 . ASN   A 1 219 ? -12.76100 -12.71500 -18.58700 1.000 44.48472 ? 415 ASN   A ND2 1 
ATOM   1661 N N   . HIS   A 1 220 ? -15.58800 -16.68100 -17.84400 1.000 47.25098 ? 416 HIS   A N   1 
ATOM   1662 C CA  . HIS   A 1 220 ? -15.73700 -17.72200 -18.86500 1.000 47.57393 ? 416 HIS   A CA  1 
ATOM   1663 C C   . HIS   A 1 220 ? -16.62900 -18.84400 -18.34200 1.000 52.11255 ? 416 HIS   A C   1 
ATOM   1664 O O   . HIS   A 1 220 ? -16.20000 -19.99700 -18.24100 1.000 50.24756 ? 416 HIS   A O   1 
ATOM   1665 C CB  . HIS   A 1 220 ? -14.37200 -18.27000 -19.27900 1.000 46.82704 ? 416 HIS   A CB  1 
ATOM   1666 C CG  . HIS   A 1 220 ? -13.44900 -17.23500 -19.84400 1.000 47.06393 ? 416 HIS   A CG  1 
ATOM   1667 N ND1 . HIS   A 1 220 ? -13.35900 -16.97400 -21.19400 1.000 49.97409 ? 416 HIS   A ND1 1 
ATOM   1668 C CD2 . HIS   A 1 220 ? -12.56800 -16.40300 -19.24100 1.000 44.38225 ? 416 HIS   A CD2 1 
ATOM   1669 C CE1 . HIS   A 1 220 ? -12.46900 -16.01900 -21.39800 1.000 48.77403 ? 416 HIS   A CE1 1 
ATOM   1670 N NE2 . HIS   A 1 220 ? -11.97400 -15.65500 -20.22900 1.000 42.46645 ? 416 HIS   A NE2 1 
ATOM   1671 N N   . PRO   A 1 221 ? -17.89000 -18.54300 -18.01200 1.000 56.49281 ? 417 PRO   A N   1 
ATOM   1672 C CA  . PRO   A 1 221 ? -18.73000 -19.54900 -17.33300 1.000 59.35577 ? 417 PRO   A CA  1 
ATOM   1673 C C   . PRO   A 1 221 ? -19.00200 -20.79800 -18.15500 1.000 61.16949 ? 417 PRO   A C   1 
ATOM   1674 O O   . PRO   A 1 221 ? -19.49100 -21.78400 -17.58900 1.000 67.61949 ? 417 PRO   A O   1 
ATOM   1675 C CB  . PRO   A 1 221 ? -20.03600 -18.79100 -17.04000 1.000 60.36632 ? 417 PRO   A CB  1 
ATOM   1676 C CG  . PRO   A 1 221 ? -20.03100 -17.62800 -17.96800 1.000 59.87649 ? 417 PRO   A CG  1 
ATOM   1677 C CD  . PRO   A 1 221 ? -18.59900 -17.26300 -18.18300 1.000 58.15809 ? 417 PRO   A CD  1 
ATOM   1678 N N   . ASP   A 1 222 ? -18.70300 -20.79900 -19.45500 1.000 59.01952 ? 418 ASP   A N   1 
ATOM   1679 C CA  . ASP   A 1 222 ? -19.00400 -21.97400 -20.26600 1.000 61.04265 ? 418 ASP   A CA  1 
ATOM   1680 C C   . ASP   A 1 222 ? -17.89000 -23.00800 -20.18700 1.000 63.51699 ? 418 ASP   A C   1 
ATOM   1681 O O   . ASP   A 1 222 ? -18.16200 -24.21400 -20.14400 1.000 67.23356 ? 418 ASP   A O   1 
ATOM   1682 C CB  . ASP   A 1 222 ? -19.23200 -21.57500 -21.72300 1.000 63.77879 ? 418 ASP   A CB  1 
ATOM   1683 C CG  . ASP   A 1 222 ? -18.26100 -20.50700 -22.19500 1.000 72.61193 ? 418 ASP   A CG  1 
ATOM   1684 O OD1 . ASP   A 1 222 ? -17.39400 -20.83100 -23.03900 1.000 78.18193 ? 418 ASP   A OD1 1 
ATOM   1685 O OD2 . ASP   A 1 222 ? -18.34800 -19.35500 -21.72000 1.000 68.80846 ? 418 ASP   A OD2 1 
ATOM   1686 N N   . ASP   A 1 223 ? -16.63500 -22.56300 -20.17300 1.000 57.39216 ? 419 ASP   A N   1 
ATOM   1687 C CA  . ASP   A 1 223 ? -15.49500 -23.47400 -20.23400 1.000 57.44275 ? 419 ASP   A CA  1 
ATOM   1688 C C   . ASP   A 1 223 ? -15.21600 -23.92900 -18.80600 1.000 55.98841 ? 419 ASP   A C   1 
ATOM   1689 O O   . ASP   A 1 223 ? -14.49800 -23.27400 -18.04800 1.000 52.52171 ? 419 ASP   A O   1 
ATOM   1690 C CB  . ASP   A 1 223 ? -14.29200 -22.79100 -20.87500 1.000 51.08964 ? 419 ASP   A CB  1 
ATOM   1691 C CG  . ASP   A 1 223 ? -13.13300 -23.74500 -21.13000 1.000 51.29358 ? 419 ASP   A CG  1 
ATOM   1692 O OD1 . ASP   A 1 223 ? -12.36500 -23.48800 -22.08200 1.000 60.91498 ? 419 ASP   A OD1 1 
ATOM   1693 O OD2 . ASP   A 1 223 ? -12.99600 -24.76300 -20.41600 1.000 55.66619 ? 419 ASP   A OD2 1 
ATOM   1694 N N   . ILE   A 1 224 ? -15.78800 -25.08200 -18.44500 1.000 56.87396 ? 420 ILE   A N   1 
ATOM   1695 C CA  . ILE   A 1 224 ? -15.76600 -25.55200 -17.06300 1.000 55.50595 ? 420 ILE   A CA  1 
ATOM   1696 C C   . ILE   A 1 224 ? -14.37000 -25.95500 -16.60200 1.000 56.01490 ? 420 ILE   A C   1 
ATOM   1697 O O   . ILE   A 1 224 ? -14.10200 -25.96000 -15.39500 1.000 58.11180 ? 420 ILE   A O   1 
ATOM   1698 C CB  . ILE   A 1 224 ? -16.74300 -26.73300 -16.89700 1.000 60.61938 ? 420 ILE   A CB  1 
ATOM   1699 C CG1 . ILE   A 1 224 ? -18.01600 -26.49000 -17.71400 1.000 64.16551 ? 420 ILE   A CG1 1 
ATOM   1700 C CG2 . ILE   A 1 224 ? -17.09900 -26.93400 -15.43000 1.000 61.23619 ? 420 ILE   A CG2 1 
ATOM   1701 C CD1 . ILE   A 1 224 ? -18.88600 -25.36200 -17.18700 1.000 64.59980 ? 420 ILE   A CD1 1 
ATOM   1702 N N   . PHE   A 1 225 ? -13.46900 -26.29800 -17.52600 1.000 49.07574 ? 421 PHE   A N   1 
ATOM   1703 C CA  . PHE   A 1 225 ? -12.13500 -26.77800 -17.18400 1.000 47.70144 ? 421 PHE   A CA  1 
ATOM   1704 C C   . PHE   A 1 225 ? -11.03400 -25.77800 -17.53100 1.000 47.60823 ? 421 PHE   A C   1 
ATOM   1705 O O   . PHE   A 1 225 ? -9.86200  -26.16100 -17.61600 1.000 43.86252 ? 421 PHE   A O   1 
ATOM   1706 C CB  . PHE   A 1 225 ? -11.85800 -28.11100 -17.88200 1.000 51.77814 ? 421 PHE   A CB  1 
ATOM   1707 C CG  . PHE   A 1 225 ? -12.88700 -29.16900 -17.60900 1.000 55.93041 ? 421 PHE   A CG  1 
ATOM   1708 C CD1 . PHE   A 1 225 ? -13.94000 -29.37200 -18.48500 1.000 58.24604 ? 421 PHE   A CD1 1 
ATOM   1709 C CD2 . PHE   A 1 225 ? -12.79400 -29.97000 -16.48200 1.000 57.86358 ? 421 PHE   A CD2 1 
ATOM   1710 C CE1 . PHE   A 1 225 ? -14.88800 -30.35100 -18.24000 1.000 60.82321 ? 421 PHE   A CE1 1 
ATOM   1711 C CE2 . PHE   A 1 225 ? -13.73600 -30.95000 -16.23100 1.000 61.61234 ? 421 PHE   A CE2 1 
ATOM   1712 C CZ  . PHE   A 1 225 ? -14.78500 -31.14000 -17.11100 1.000 60.04617 ? 421 PHE   A CZ  1 
ATOM   1713 N N   . LEU   A 1 226 ? -11.37900 -24.50400 -17.73300 1.000 43.93393 ? 422 LEU   A N   1 
ATOM   1714 C CA  . LEU   A 1 226 ? -10.37200 -23.53400 -18.15500 1.000 41.53816 ? 422 LEU   A CA  1 
ATOM   1715 C C   . LEU   A 1 226 ? -9.26600  -23.38500 -17.11000 1.000 40.26349 ? 422 LEU   A C   1 
ATOM   1716 O O   . LEU   A 1 226 ? -8.08800  -23.25700 -17.46000 1.000 38.49075 ? 422 LEU   A O   1 
ATOM   1717 C CB  . LEU   A 1 226 ? -11.03200 -22.18600 -18.44200 1.000 41.27181 ? 422 LEU   A CB  1 
ATOM   1718 C CG  . LEU   A 1 226 ? -10.13600 -21.06200 -18.97400 1.000 41.38612 ? 422 LEU   A CG  1 
ATOM   1719 C CD1 . LEU   A 1 226 ? -9.19900  -21.57000 -20.06000 1.000 38.66421 ? 422 LEU   A CD1 1 
ATOM   1720 C CD2 . LEU   A 1 226 ? -10.97700 -19.89900 -19.48600 1.000 38.78261 ? 422 LEU   A CD2 1 
ATOM   1721 N N   . PHE   A 1 227 ? -9.62300  -23.42000 -15.82500 1.000 35.07211 ? 423 PHE   A N   1 
ATOM   1722 C CA  . PHE   A 1 227 ? -8.61100  -23.20500 -14.78300 1.000 41.42931 ? 423 PHE   A CA  1 
ATOM   1723 C C   . PHE   A 1 227 ? -7.50200  -24.24900 -14.81200 1.000 34.76331 ? 423 PHE   A C   1 
ATOM   1724 O O   . PHE   A 1 227 ? -6.32200  -23.86200 -14.89800 1.000 32.18965 ? 423 PHE   A O   1 
ATOM   1725 C CB  . PHE   A 1 227 ? -9.28300  -23.11600 -13.41100 1.000 37.35368 ? 423 PHE   A CB  1 
ATOM   1726 C CG  . PHE   A 1 227 ? -8.30400  -22.97600 -12.28600 1.000 39.76972 ? 423 PHE   A CG  1 
ATOM   1727 C CD1 . PHE   A 1 227 ? -7.45100  -21.88200 -12.22700 1.000 34.05727 ? 423 PHE   A CD1 1 
ATOM   1728 C CD2 . PHE   A 1 227 ? -8.21500  -23.94600 -11.30200 1.000 40.51181 ? 423 PHE   A CD2 1 
ATOM   1729 C CE1 . PHE   A 1 227 ? -6.53500  -21.75600 -11.20100 1.000 35.75142 ? 423 PHE   A CE1 1 
ATOM   1730 C CE2 . PHE   A 1 227 ? -7.30100  -23.82300 -10.26700 1.000 41.22370 ? 423 PHE   A CE2 1 
ATOM   1731 C CZ  . PHE   A 1 227 ? -6.46200  -22.72600 -10.21700 1.000 41.83485 ? 423 PHE   A CZ  1 
ATOM   1732 N N   . PRO   A 1 228 ? -7.77700  -25.56000 -14.74800 1.000 38.85835 ? 424 PRO   A N   1 
ATOM   1733 C CA  . PRO   A 1 228 ? -6.65900  -26.51500 -14.85500 1.000 36.94388 ? 424 PRO   A CA  1 
ATOM   1734 C C   . PRO   A 1 228 ? -5.98200  -26.47400 -16.21500 1.000 34.58660 ? 424 PRO   A C   1 
ATOM   1735 O O   . PRO   A 1 228 ? -4.77600  -26.74300 -16.30000 1.000 33.95146 ? 424 PRO   A O   1 
ATOM   1736 C CB  . PRO   A 1 228 ? -7.30600  -27.88300 -14.57800 1.000 40.06973 ? 424 PRO   A CB  1 
ATOM   1737 C CG  . PRO   A 1 228 ? -8.76700  -27.68400 -14.73900 1.000 40.66839 ? 424 PRO   A CG  1 
ATOM   1738 C CD  . PRO   A 1 228 ? -9.06500  -26.23600 -14.49900 1.000 41.10196 ? 424 PRO   A CD  1 
ATOM   1739 N N   . LYS   A 1 229 ? -6.71900  -26.13700 -17.27800 1.000 33.03067 ? 425 LYS   A N   1 
ATOM   1740 C CA  . LYS   A 1 229 ? -6.08900  -25.92900 -18.57900 1.000 32.83055 ? 425 LYS   A CA  1 
ATOM   1741 C C   . LYS   A 1 229 ? -5.01200  -24.85400 -18.48800 1.000 36.27686 ? 425 LYS   A C   1 
ATOM   1742 O O   . LYS   A 1 229 ? -3.89300  -25.03200 -18.98200 1.000 30.89182 ? 425 LYS   A O   1 
ATOM   1743 C CB  . LYS   A 1 229 ? -7.13800  -25.53300 -19.62000 1.000 39.10328 ? 425 LYS   A CB  1 
ATOM   1744 C CG  . LYS   A 1 229 ? -7.92500  -26.68200 -20.22200 1.000 48.48741 ? 425 LYS   A CG  1 
ATOM   1745 C CD  . LYS   A 1 229 ? -8.88400  -26.16500 -21.29200 1.000 52.77797 ? 425 LYS   A CD  1 
ATOM   1746 C CE  . LYS   A 1 229 ? -9.88200  -27.23700 -21.69600 1.000 50.83190 ? 425 LYS   A CE  1 
ATOM   1747 N NZ  . LYS   A 1 229 ? -11.02100 -26.70200 -22.48900 1.000 55.80480 ? 425 LYS   A NZ  1 
ATOM   1748 N N   . LEU   A 1 230 ? -5.34300  -23.72500 -17.85000 1.000 34.25460 ? 426 LEU   A N   1 
ATOM   1749 C CA  . LEU   A 1 230 ? -4.38500  -22.63400 -17.70100 1.000 36.29009 ? 426 LEU   A CA  1 
ATOM   1750 C C   . LEU   A 1 230 ? -3.21700  -23.03800 -16.81200 1.000 32.66567 ? 426 LEU   A C   1 
ATOM   1751 O O   . LEU   A 1 230 ? -2.07300  -22.64700 -17.06800 1.000 34.34462 ? 426 LEU   A O   1 
ATOM   1752 C CB  . LEU   A 1 230 ? -5.09000  -21.40500 -17.13100 1.000 36.22434 ? 426 LEU   A CB  1 
ATOM   1753 C CG  . LEU   A 1 230 ? -5.67200  -20.43900 -18.15900 1.000 43.41123 ? 426 LEU   A CG  1 
ATOM   1754 C CD1 . LEU   A 1 230 ? -6.10700  -19.14900 -17.47800 1.000 35.64791 ? 426 LEU   A CD1 1 
ATOM   1755 C CD2 . LEU   A 1 230 ? -4.66100  -20.16400 -19.27700 1.000 38.92342 ? 426 LEU   A CD2 1 
ATOM   1756 N N   . LEU   A 1 231 ? -3.48800  -23.81300 -15.75700 1.000 33.41312 ? 427 LEU   A N   1 
ATOM   1757 C CA  . LEU   A 1 231 ? -2.41000  -24.32100 -14.91600 1.000 35.96695 ? 427 LEU   A CA  1 
ATOM   1758 C C   . LEU   A 1 231 ? -1.39100  -25.10400 -15.73600 1.000 34.04544 ? 427 LEU   A C   1 
ATOM   1759 O O   . LEU   A 1 231 ? -0.17900  -24.94400 -15.55300 1.000 38.19876 ? 427 LEU   A O   1 
ATOM   1760 C CB  . LEU   A 1 231 ? -2.97900  -25.19400 -13.79200 1.000 36.71071 ? 427 LEU   A CB  1 
ATOM   1761 C CG  . LEU   A 1 231 ? -3.80100  -24.51500 -12.69200 1.000 41.14977 ? 427 LEU   A CG  1 
ATOM   1762 C CD1 . LEU   A 1 231 ? -4.11200  -25.50800 -11.57700 1.000 39.16656 ? 427 LEU   A CD1 1 
ATOM   1763 C CD2 . LEU   A 1 231 ? -3.06600  -23.30400 -12.13700 1.000 39.51255 ? 427 LEU   A CD2 1 
ATOM   1764 N N   . GLN   A 1 232 ? -1.85800  -25.94700 -16.65800 1.000 36.32833 ? 428 GLN   A N   1 
ATOM   1765 C CA  . GLN   A 1 232 ? -0.91400  -26.69000 -17.48800 1.000 34.61107 ? 428 GLN   A CA  1 
ATOM   1766 C C   . GLN   A 1 232 ? -0.19300  -25.77000 -18.47500 1.000 36.53307 ? 428 GLN   A C   1 
ATOM   1767 O O   . GLN   A 1 232 ? 0.99700   -25.97100 -18.75200 1.000 32.70691 ? 428 GLN   A O   1 
ATOM   1768 C CB  . GLN   A 1 232 ? -1.63200  -27.83000 -18.21700 1.000 37.41752 ? 428 GLN   A CB  1 
ATOM   1769 C CG  . GLN   A 1 232 ? -0.89600  -28.31700 -19.45100 1.000 40.47770 ? 428 GLN   A CG  1 
ATOM   1770 C CD  . GLN   A 1 232 ? -1.65700  -29.36800 -20.22900 1.000 45.31948 ? 428 GLN   A CD  1 
ATOM   1771 O OE1 . GLN   A 1 232 ? -2.61800  -29.06600 -20.93700 1.000 46.59387 ? 428 GLN   A OE1 1 
ATOM   1772 N NE2 . GLN   A 1 232 ? -1.21400  -30.61200 -20.11700 1.000 44.78372 ? 428 GLN   A NE2 1 
ATOM   1773 N N   . LYS   A 1 233 ? -0.88000  -24.74500 -18.99700 1.000 36.51906 ? 429 LYS   A N   1 
ATOM   1774 C CA  . LYS   A 1 233 ? -0.19800  -23.76700 -19.84400 1.000 38.20048 ? 429 LYS   A CA  1 
ATOM   1775 C C   . LYS   A 1 233 ? 0.97800   -23.13400 -19.11400 1.000 36.51087 ? 429 LYS   A C   1 
ATOM   1776 O O   . LYS   A 1 233 ? 1.99000   -22.78700 -19.73400 1.000 36.20160 ? 429 LYS   A O   1 
ATOM   1777 C CB  . LYS   A 1 233 ? -1.18100  -22.68800 -20.30600 1.000 34.52751 ? 429 LYS   A CB  1 
ATOM   1778 C CG  . LYS   A 1 233 ? -2.29300  -23.21900 -21.19900 1.000 41.07329 ? 429 LYS   A CG  1 
ATOM   1779 C CD  . LYS   A 1 233 ? -1.72600  -23.79500 -22.48900 1.000 37.48112 ? 429 LYS   A CD  1 
ATOM   1780 C CE  . LYS   A 1 233 ? -2.83600  -24.17400 -23.46400 1.000 43.56158 ? 429 LYS   A CE  1 
ATOM   1781 N NZ  . LYS   A 1 233 ? -2.37400  -25.18500 -24.46200 1.000 43.41236 ? 429 LYS   A NZ  1 
ATOM   1782 N N   . MET   A 1 234 ? 0.86000   -22.98700 -17.79700 1.000 34.85083 ? 430 MET   A N   1 
ATOM   1783 C CA  . MET   A 1 234 ? 1.96600   -22.50200 -16.98600 1.000 38.03358 ? 430 MET   A CA  1 
ATOM   1784 C C   . MET   A 1 234 ? 3.15900   -23.44800 -17.08100 1.000 37.69386 ? 430 MET   A C   1 
ATOM   1785 O O   . MET   A 1 234 ? 4.30400   -23.01000 -17.23900 1.000 35.71058 ? 430 MET   A O   1 
ATOM   1786 C CB  . MET   A 1 234 ? 1.47600   -22.37700 -15.54700 1.000 43.06848 ? 430 MET   A CB  1 
ATOM   1787 C CG  . MET   A 1 234 ? 0.55700   -21.19400 -15.31100 1.000 41.93014 ? 430 MET   A CG  1 
ATOM   1788 S SD  . MET   A 1 234 ? 0.48200   -20.69200 -13.58800 1.000 48.23513 ? 430 MET   A SD  1 
ATOM   1789 C CE  . MET   A 1 234 ? 2.11300   -21.16400 -13.01900 1.000 52.16930 ? 430 MET   A CE  1 
ATOM   1790 N N   . ALA   A 1 235 ? 2.90300   -24.75800 -17.00200 1.000 36.92808 ? 431 ALA   A N   1 
ATOM   1791 C CA  . ALA   A 1 235 ? 3.97800   -25.73900 -17.11800 1.000 40.31606 ? 431 ALA   A CA  1 
ATOM   1792 C C   . ALA   A 1 235 ? 4.54500   -25.77500 -18.53300 1.000 36.25363 ? 431 ALA   A C   1 
ATOM   1793 O O   . ALA   A 1 235 ? 5.76300   -25.89000 -18.71300 1.000 38.04505 ? 431 ALA   A O   1 
ATOM   1794 C CB  . ALA   A 1 235 ? 3.47400   -27.12300 -16.69400 1.000 37.79628 ? 431 ALA   A CB  1 
ATOM   1795 N N   . ASP   A 1 236 ? 3.68200   -25.68100 -19.54900 1.000 36.19126 ? 432 ASP   A N   1 
ATOM   1796 C CA  . ASP   A 1 236 ? 4.16900   -25.59000 -20.92300 1.000 36.21461 ? 432 ASP   A CA  1 
ATOM   1797 C C   . ASP   A 1 236 ? 5.13700   -24.42500 -21.09800 1.000 37.05497 ? 432 ASP   A C   1 
ATOM   1798 O O   . ASP   A 1 236 ? 6.15900   -24.55600 -21.77900 1.000 35.45661 ? 432 ASP   A O   1 
ATOM   1799 C CB  . ASP   A 1 236 ? 3.00100   -25.44200 -21.90100 1.000 39.00735 ? 432 ASP   A CB  1 
ATOM   1800 C CG  . ASP   A 1 236 ? 2.06800   -26.63600 -21.89900 1.000 46.27593 ? 432 ASP   A CG  1 
ATOM   1801 O OD1 . ASP   A 1 236 ? 2.39700   -27.67200 -21.28100 1.000 41.63364 ? 432 ASP   A OD1 1 
ATOM   1802 O OD2 . ASP   A 1 236 ? 1.00000   -26.53600 -22.54400 1.000 44.90898 ? 432 ASP   A OD2 1 
ATOM   1803 N N   . LEU   A 1 237 ? 4.83400   -23.27700 -20.48700 1.000 35.31392 ? 433 LEU   A N   1 
ATOM   1804 C CA  . LEU   A 1 237 ? 5.68000   -22.10100 -20.67800 1.000 34.04777 ? 433 LEU   A CA  1 
ATOM   1805 C C   . LEU   A 1 237 ? 7.06900   -22.31900 -20.08900 1.000 37.71194 ? 433 LEU   A C   1 
ATOM   1806 O O   . LEU   A 1 237 ? 8.07500   -21.90700 -20.68200 1.000 35.21288 ? 433 LEU   A O   1 
ATOM   1807 C CB  . LEU   A 1 237 ? 5.01400   -20.86600 -20.06100 1.000 34.31896 ? 433 LEU   A CB  1 
ATOM   1808 C CG  . LEU   A 1 237 ? 3.96700   -20.17500 -20.93300 1.000 35.87128 ? 433 LEU   A CG  1 
ATOM   1809 C CD1 . LEU   A 1 237 ? 3.05500   -19.27600 -20.09000 1.000 34.78844 ? 433 LEU   A CD1 1 
ATOM   1810 C CD2 . LEU   A 1 237 ? 4.64800   -19.38600 -22.04100 1.000 33.58528 ? 433 LEU   A CD2 1 
ATOM   1811 N N   . ARG   A 1 238 ? 7.14400   -22.96500 -18.92200 1.000 37.01852 ? 434 ARG   A N   1 
ATOM   1812 C CA  . ARG   A 1 238 ? 8.44300   -23.28500 -18.34100 1.000 40.33239 ? 434 ARG   A CA  1 
ATOM   1813 C C   . ARG   A 1 238 ? 9.25600   -24.17400 -19.27300 1.000 41.68286 ? 434 ARG   A C   1 
ATOM   1814 O O   . ARG   A 1 238 ? 10.46700  -23.98000 -19.42700 1.000 44.21680 ? 434 ARG   A O   1 
ATOM   1815 C CB  . ARG   A 1 238 ? 8.25800   -23.96900 -16.99000 1.000 47.62029 ? 434 ARG   A CB  1 
ATOM   1816 C CG  . ARG   A 1 238 ? 9.35400   -23.68100 -15.98200 1.000 47.71239 ? 434 ARG   A CG  1 
ATOM   1817 C CD  . ARG   A 1 238 ? 9.04400   -24.37400 -14.67300 1.000 47.40260 ? 434 ARG   A CD  1 
ATOM   1818 N NE  . ARG   A 1 238 ? 8.22500   -23.55000 -13.79400 1.000 52.02173 ? 434 ARG   A NE  1 
ATOM   1819 C CZ  . ARG   A 1 238 ? 8.17200   -23.69300 -12.47600 1.000 56.25499 ? 434 ARG   A CZ  1 
ATOM   1820 N NH1 . ARG   A 1 238 ? 8.86900   -24.63100 -11.85600 1.000 51.46535 ? 434 ARG   A NH1 1 
ATOM   1821 N NH2 . ARG   A 1 238 ? 7.39800   -22.88000 -11.76300 1.000 54.38207 ? 434 ARG   A NH2 1 
ATOM   1822 N N   . GLN   A 1 239 ? 8.60100   -25.15800 -19.89700 1.000 41.35475 ? 435 GLN   A N   1 
ATOM   1823 C CA  . GLN   A 1 239 ? 9.26300   -26.01000 -20.88200 1.000 46.40044 ? 435 GLN   A CA  1 
ATOM   1824 C C   . GLN   A 1 239 ? 9.68400   -25.20200 -22.10300 1.000 46.75988 ? 435 GLN   A C   1 
ATOM   1825 O O   . GLN   A 1 239 ? 10.79700  -25.37200 -22.61800 1.000 43.07644 ? 435 GLN   A O   1 
ATOM   1826 C CB  . GLN   A 1 239 ? 8.32200   -27.15000 -21.28500 1.000 46.13263 ? 435 GLN   A CB  1 
ATOM   1827 C CG  . GLN   A 1 239 ? 8.96600   -28.41400 -21.85300 1.000 54.69840 ? 435 GLN   A CG  1 
ATOM   1828 C CD  . GLN   A 1 239 ? 10.33500  -28.71600 -21.27700 1.000 58.80818 ? 435 GLN   A CD  1 
ATOM   1829 O OE1 . GLN   A 1 239 ? 11.35800  -28.31400 -21.83100 1.000 61.31381 ? 435 GLN   A OE1 1 
ATOM   1830 N NE2 . GLN   A 1 239 ? 10.36100  -29.42900 -20.15700 1.000 60.85193 ? 435 GLN   A NE2 1 
ATOM   1831 N N   . LEU   A 1 240 ? 8.80200   -24.31400 -22.57300 1.000 41.92130 ? 436 LEU   A N   1 
ATOM   1832 C CA  . LEU   A 1 240 ? 9.13200   -23.45400 -23.70600 1.000 42.79538 ? 436 LEU   A CA  1 
ATOM   1833 C C   . LEU   A 1 240 ? 10.36800  -22.61000 -23.41900 1.000 40.68783 ? 436 LEU   A C   1 
ATOM   1834 O O   . LEU   A 1 240 ? 11.22900  -22.43900 -24.29200 1.000 44.37360 ? 436 LEU   A O   1 
ATOM   1835 C CB  . LEU   A 1 240 ? 7.93800   -22.55800 -24.03900 1.000 40.06227 ? 436 LEU   A CB  1 
ATOM   1836 C CG  . LEU   A 1 240 ? 7.92300   -21.84700 -25.39100 1.000 40.85383 ? 436 LEU   A CG  1 
ATOM   1837 C CD1 . LEU   A 1 240 ? 7.65900   -22.83700 -26.51800 1.000 44.39685 ? 436 LEU   A CD1 1 
ATOM   1838 C CD2 . LEU   A 1 240 ? 6.88700   -20.72300 -25.39100 1.000 41.14064 ? 436 LEU   A CD2 1 
ATOM   1839 N N   . VAL   A 1 241 ? 10.47500  -22.08000 -22.19900 1.000 40.90615 ? 437 VAL   A N   1 
ATOM   1840 C CA  . VAL   A 1 241 ? 11.58900  -21.19700 -21.86600 1.000 43.56274 ? 437 VAL   A CA  1 
ATOM   1841 C C   . VAL   A 1 241 ? 12.88700  -21.98900 -21.74100 1.000 44.68164 ? 437 VAL   A C   1 
ATOM   1842 O O   . VAL   A 1 241 ? 13.94300  -21.55400 -22.21800 1.000 47.05279 ? 437 VAL   A O   1 
ATOM   1843 C CB  . VAL   A 1 241 ? 11.27300  -20.40400 -20.58500 1.000 44.86663 ? 437 VAL   A CB  1 
ATOM   1844 C CG1 . VAL   A 1 241 ? 12.53700  -19.79100 -20.00200 1.000 44.00733 ? 437 VAL   A CG1 1 
ATOM   1845 C CG2 . VAL   A 1 241 ? 10.24000  -19.31000 -20.87800 1.000 39.45431 ? 437 VAL   A CG2 1 
ATOM   1846 N N   . THR   A 1 242 ? 12.83500  -23.15900 -21.10000 1.000 47.16334 ? 438 THR   A N   1 
ATOM   1847 C CA  . THR   A 1 242 ? 14.03300  -23.98700 -21.00100 1.000 48.26217 ? 438 THR   A CA  1 
ATOM   1848 C C   . THR   A 1 242 ? 14.54400  -24.36400 -22.38300 1.000 49.12238 ? 438 THR   A C   1 
ATOM   1849 O O   . THR   A 1 242 ? 15.75500  -24.35600 -22.63000 1.000 53.20373 ? 438 THR   A O   1 
ATOM   1850 C CB  . THR   A 1 242 ? 13.74900  -25.24000 -20.17100 1.000 48.91124 ? 438 THR   A CB  1 
ATOM   1851 O OG1 . THR   A 1 242 ? 12.65000  -25.95900 -20.74400 1.000 56.34220 ? 438 THR   A OG1 1 
ATOM   1852 C CG2 . THR   A 1 242 ? 13.42600  -24.87300 -18.73100 1.000 48.64287 ? 438 THR   A CG2 1 
ATOM   1853 N N   . GLU   A 1 243 ? 13.62900  -24.67500 -23.30300 1.000 48.01200 ? 439 GLU   A N   1 
ATOM   1854 C CA  . GLU   A 1 243 ? 14.01500  -24.95300 -24.67900 1.000 48.38384 ? 439 GLU   A CA  1 
ATOM   1855 C C   . GLU   A 1 243 ? 14.54400  -23.70700 -25.37700 1.000 50.96240 ? 439 GLU   A C   1 
ATOM   1856 O O   . GLU   A 1 243 ? 15.45100  -23.80300 -26.21100 1.000 51.35967 ? 439 GLU   A O   1 
ATOM   1857 C CB  . GLU   A 1 243 ? 12.82000  -25.52200 -25.43800 1.000 51.26524 ? 439 GLU   A CB  1 
ATOM   1858 C CG  . GLU   A 1 243 ? 12.43400  -26.93100 -25.00400 1.000 49.70342 ? 439 GLU   A CG  1 
ATOM   1859 C CD  . GLU   A 1 243 ? 11.13700  -27.39300 -25.63800 1.000 57.99677 ? 439 GLU   A CD  1 
ATOM   1860 O OE1 . GLU   A 1 243 ? 10.56000  -26.62300 -26.43900 1.000 60.88193 ? 439 GLU   A OE1 1 
ATOM   1861 O OE2 . GLU   A 1 243 ? 10.69400  -28.52200 -25.34300 1.000 55.05980 ? 439 GLU   A OE2 1 
ATOM   1862 N N   . HIS   A 1 244 ? 13.99100  -22.53400 -25.05900 1.000 51.71406 ? 440 HIS   A N   1 
ATOM   1863 C CA  . HIS   A 1 244 ? 14.45400  -21.30400 -25.69500 1.000 48.85495 ? 440 HIS   A CA  1 
ATOM   1864 C C   . HIS   A 1 244 ? 15.83000  -20.89700 -25.18800 1.000 48.38888 ? 440 HIS   A C   1 
ATOM   1865 O O   . HIS   A 1 244 ? 16.62100  -20.31800 -25.94300 1.000 49.93756 ? 440 HIS   A O   1 
ATOM   1866 C CB  . HIS   A 1 244 ? 13.44100  -20.18100 -25.45900 1.000 47.34816 ? 440 HIS   A CB  1 
ATOM   1867 C CG  . HIS   A 1 244 ? 13.90900  -18.83200 -25.90900 1.000 45.18328 ? 440 HIS   A CG  1 
ATOM   1868 N ND1 . HIS   A 1 244 ? 13.65600  -18.33800 -27.17100 1.000 42.96987 ? 440 HIS   A ND1 1 
ATOM   1869 C CD2 . HIS   A 1 244 ? 14.60100  -17.86600 -25.26000 1.000 44.44497 ? 440 HIS   A CD2 1 
ATOM   1870 C CE1 . HIS   A 1 244 ? 14.17500  -17.12700 -27.28000 1.000 44.37446 ? 440 HIS   A CE1 1 
ATOM   1871 N NE2 . HIS   A 1 244 ? 14.75500  -16.81800 -26.13400 1.000 43.43643 ? 440 HIS   A NE2 1 
ATOM   1872 N N   . ALA   A 1 245 ? 16.13400  -21.19500 -23.92200 1.000 45.34339 ? 441 ALA   A N   1 
ATOM   1873 C CA  . ALA   A 1 245 ? 17.43300  -20.83900 -23.36100 1.000 50.17461 ? 441 ALA   A CA  1 
ATOM   1874 C C   . ALA   A 1 245 ? 18.57600  -21.50700 -24.11500 1.000 58.45790 ? 441 ALA   A C   1 
ATOM   1875 O O   . ALA   A 1 245 ? 19.67100  -20.94000 -24.21600 1.000 53.90584 ? 441 ALA   A O   1 
ATOM   1876 C CB  . ALA   A 1 245 ? 17.48500  -21.21700 -21.88100 1.000 51.35363 ? 441 ALA   A CB  1 
ATOM   1877 N N   . GLN   A 1 246 ? 18.34400  -22.70500 -24.65700 1.000 51.97203 ? 442 GLN   A N   1 
ATOM   1878 C CA  . GLN   A 1 246 ? 19.40600  -23.40200 -25.36900 1.000 57.22881 ? 442 GLN   A CA  1 
ATOM   1879 C C   . GLN   A 1 246 ? 19.60400  -22.84300 -26.77000 1.000 59.53082 ? 442 GLN   A C   1 
ATOM   1880 O O   . GLN   A 1 246 ? 20.70900  -22.93200 -27.31600 1.000 59.79491 ? 442 GLN   A O   1 
ATOM   1881 C CB  . GLN   A 1 246 ? 19.10500  -24.89900 -25.41200 1.000 57.82477 ? 442 GLN   A CB  1 
ATOM   1882 C CG  . GLN   A 1 246 ? 19.61600  -25.62300 -24.17900 1.000 63.90268 ? 442 GLN   A CG  1 
ATOM   1883 C CD  . GLN   A 1 246 ? 18.49600  -26.05000 -23.25500 1.000 65.09087 ? 442 GLN   A CD  1 
ATOM   1884 O OE1 . GLN   A 1 246 ? 17.65200  -26.86900 -23.62400 1.000 65.87826 ? 442 GLN   A OE1 1 
ATOM   1885 N NE2 . GLN   A 1 246 ? 18.46600  -25.47700 -22.05500 1.000 62.63731 ? 442 GLN   A NE2 1 
ATOM   1886 N N   . LEU   A 1 247 ? 18.55700  -22.26400 -27.36400 1.000 56.64028 ? 443 LEU   A N   1 
ATOM   1887 C CA  . LEU   A 1 247 ? 18.75100  -21.47500 -28.57500 1.000 55.74645 ? 443 LEU   A CA  1 
ATOM   1888 C C   . LEU   A 1 247 ? 19.59500  -20.24200 -28.28300 1.000 55.26704 ? 443 LEU   A C   1 
ATOM   1889 O O   . LEU   A 1 247 ? 20.47400  -19.88000 -29.07300 1.000 59.05530 ? 443 LEU   A O   1 
ATOM   1890 C CB  . LEU   A 1 247 ? 17.40000  -21.07800 -29.16900 1.000 55.50919 ? 443 LEU   A CB  1 
ATOM   1891 C CG  . LEU   A 1 247 ? 16.54600  -22.21000 -29.74100 1.000 54.36679 ? 443 LEU   A CG  1 
ATOM   1892 C CD1 . LEU   A 1 247 ? 15.15200  -21.71000 -30.09500 1.000 51.82186 ? 443 LEU   A CD1 1 
ATOM   1893 C CD2 . LEU   A 1 247 ? 17.22600  -22.82700 -30.95700 1.000 57.30898 ? 443 LEU   A CD2 1 
ATOM   1894 N N   . VAL   A 1 248 ? 19.34300  -19.58800 -27.14400 1.000 56.05839 ? 444 VAL   A N   1 
ATOM   1895 C CA  . VAL   A 1 248 ? 20.18400  -18.47700 -26.70700 1.000 55.56732 ? 444 VAL   A CA  1 
ATOM   1896 C C   . VAL   A 1 248 ? 21.63200  -18.92900 -26.57100 1.000 62.69964 ? 444 VAL   A C   1 
ATOM   1897 O O   . VAL   A 1 248 ? 22.56600  -18.19400 -26.91500 1.000 64.24192 ? 444 VAL   A O   1 
ATOM   1898 C CB  . VAL   A 1 248 ? 19.65100  -17.89400 -25.38300 1.000 52.87726 ? 444 VAL   A CB  1 
ATOM   1899 C CG1 . VAL   A 1 248 ? 20.58800  -16.82700 -24.85000 1.000 52.00977 ? 444 VAL   A CG1 1 
ATOM   1900 C CG2 . VAL   A 1 248 ? 18.24200  -17.33500 -25.56600 1.000 51.83151 ? 444 VAL   A CG2 1 
ATOM   1901 N N   . GLN   A 1 249 ? 21.83900  -20.15200 -26.07900 1.000 61.09809 ? 445 GLN   A N   1 
ATOM   1902 C CA  . GLN   A 1 249 ? 23.19300  -20.64600 -25.85800 1.000 65.37931 ? 445 GLN   A CA  1 
ATOM   1903 C C   . GLN   A 1 249 ? 23.92000  -20.85200 -27.18200 1.000 65.73103 ? 445 GLN   A C   1 
ATOM   1904 O O   . GLN   A 1 249 ? 25.12100  -20.57600 -27.28800 1.000 68.93428 ? 445 GLN   A O   1 
ATOM   1905 C CB  . GLN   A 1 249 ? 23.14200  -21.94900 -25.05800 1.000 63.67402 ? 445 GLN   A CB  1 
ATOM   1906 C CG  . GLN   A 1 249 ? 24.47300  -22.38300 -24.46800 1.000 71.30003 ? 445 GLN   A CG  1 
ATOM   1907 C CD  . GLN   A 1 249 ? 25.31200  -21.20800 -24.00300 1.000 77.42774 ? 445 GLN   A CD  1 
ATOM   1908 O OE1 . GLN   A 1 249 ? 24.92500  -20.48000 -23.08700 1.000 76.86217 ? 445 GLN   A OE1 1 
ATOM   1909 N NE2 . GLN   A 1 249 ? 26.47000  -21.02100 -24.62600 1.000 78.93766 ? 445 GLN   A NE2 1 
ATOM   1910 N N   . ILE   A 1 250 ? 23.20300  -21.33400 -28.20200 1.000 59.04665 ? 446 ILE   A N   1 
ATOM   1911 C CA  . ILE   A 1 250 ? 23.78400  -21.50200 -29.53100 1.000 61.32237 ? 446 ILE   A CA  1 
ATOM   1912 C C   . ILE   A 1 250 ? 24.21800  -20.15900 -30.10400 1.000 67.86337 ? 446 ILE   A C   1 
ATOM   1913 O O   . ILE   A 1 250 ? 25.21200  -20.07700 -30.83800 1.000 67.92216 ? 446 ILE   A O   1 
ATOM   1914 C CB  . ILE   A 1 250 ? 22.77600  -22.21600 -30.45600 1.000 58.69121 ? 446 ILE   A CB  1 
ATOM   1915 C CG1 . ILE   A 1 250 ? 22.53100  -23.64800 -29.97700 1.000 55.25884 ? 446 ILE   A CG1 1 
ATOM   1916 C CG2 . ILE   A 1 250 ? 23.25500  -22.21300 -31.90100 1.000 62.32547 ? 446 ILE   A CG2 1 
ATOM   1917 C CD1 . ILE   A 1 250 ? 21.50100  -24.39500 -30.79600 1.000 56.70706 ? 446 ILE   A CD1 1 
ATOM   1918 N N   . ILE   A 1 251 ? 23.49900  -19.08700 -29.77100 1.000 66.62554 ? 447 ILE   A N   1 
ATOM   1919 C CA  . ILE   A 1 251 ? 23.84000  -17.76600 -30.29000 1.000 66.20327 ? 447 ILE   A CA  1 
ATOM   1920 C C   . ILE   A 1 251 ? 25.03800  -17.18600 -29.54800 1.000 67.02552 ? 447 ILE   A C   1 
ATOM   1921 O O   . ILE   A 1 251 ? 25.91300  -16.55900 -30.15700 1.000 69.86371 ? 447 ILE   A O   1 
ATOM   1922 C CB  . ILE   A 1 251 ? 22.61500  -16.83700 -30.21100 1.000 64.44014 ? 447 ILE   A CB  1 
ATOM   1923 C CG1 . ILE   A 1 251 ? 21.45700  -17.41300 -31.03500 1.000 60.53373 ? 447 ILE   A CG1 1 
ATOM   1924 C CG2 . ILE   A 1 251 ? 22.97600  -15.42600 -30.66500 1.000 60.61699 ? 447 ILE   A CG2 1 
ATOM   1925 C CD1 . ILE   A 1 251 ? 21.35800  -16.86500 -32.43600 1.000 64.73383 ? 447 ILE   A CD1 1 
ATOM   1926 N N   . LYS   A 1 252 ? 25.09400  -17.37700 -28.22600 1.000 67.35867 ? 448 LYS   A N   1 
ATOM   1927 C CA  . LYS   A 1 252 ? 26.24600  -16.92800 -27.44900 1.000 67.89805 ? 448 LYS   A CA  1 
ATOM   1928 C C   . LYS   A 1 252 ? 27.54600  -17.46000 -28.03800 1.000 71.40592 ? 448 LYS   A C   1 
ATOM   1929 O O   . LYS   A 1 252 ? 28.53700  -16.72800 -28.15000 1.000 75.08511 ? 448 LYS   A O   1 
ATOM   1930 C CB  . LYS   A 1 252 ? 26.11500  -17.38800 -25.99300 1.000 69.16572 ? 448 LYS   A CB  1 
ATOM   1931 C CG  . LYS   A 1 252 ? 25.03700  -16.69200 -25.17900 1.000 71.46214 ? 448 LYS   A CG  1 
ATOM   1932 C CD  . LYS   A 1 252 ? 25.54300  -16.32800 -23.78700 1.000 70.33884 ? 448 LYS   A CD  1 
ATOM   1933 C CE  . LYS   A 1 252 ? 25.10900  -17.36100 -22.75600 1.000 76.84744 ? 448 LYS   A CE  1 
ATOM   1934 N NZ  . LYS   A 1 252 ? 24.41600  -16.76000 -21.58700 1.000 74.18708 ? 448 LYS   A NZ  1 
ATOM   1935 N N   . LYS   A 1 253 ? 27.54800  -18.72800 -28.44100 1.000 69.38108 ? 449 LYS   A N   1 
ATOM   1936 C CA  . LYS   A 1 253 ? 28.76500  -19.44200 -28.79700 1.000 71.17315 ? 449 LYS   A CA  1 
ATOM   1937 C C   . LYS   A 1 253 ? 29.12800  -19.30400 -30.27100 1.000 75.54519 ? 449 LYS   A C   1 
ATOM   1938 O O   . LYS   A 1 253 ? 30.30400  -19.11400 -30.60000 1.000 78.22096 ? 449 LYS   A O   1 
ATOM   1939 C CB  . LYS   A 1 253 ? 28.60800  -20.92300 -28.44200 1.000 68.32891 ? 449 LYS   A CB  1 
ATOM   1940 C CG  . LYS   A 1 253 ? 28.92600  -21.24400 -26.99200 1.000 76.00267 ? 449 LYS   A CG  1 
ATOM   1941 C CD  . LYS   A 1 253 ? 28.72300  -22.72100 -26.68600 1.000 82.36704 ? 449 LYS   A CD  1 
ATOM   1942 C CE  . LYS   A 1 253 ? 29.90700  -23.30200 -25.92900 1.000 83.18073 ? 449 LYS   A CE  1 
ATOM   1943 N NZ  . LYS   A 1 253 ? 30.65500  -24.29900 -26.74500 1.000 79.71035 ? 449 LYS   A NZ  1 
ATOM   1944 N N   . THR   A 1 254 ? 28.14100  -19.38900 -31.16800 1.000 74.02093 ? 450 THR   A N   1 
ATOM   1945 C CA  . THR   A 1 254 ? 28.40100  -19.59600 -32.58900 1.000 70.40459 ? 450 THR   A CA  1 
ATOM   1946 C C   . THR   A 1 254 ? 27.86200  -18.47600 -33.47600 1.000 73.92586 ? 450 THR   A C   1 
ATOM   1947 O O   . THR   A 1 254 ? 27.62400  -18.70500 -34.66700 1.000 75.38673 ? 450 THR   A O   1 
ATOM   1948 C CB  . THR   A 1 254 ? 27.81300  -20.93400 -33.03900 1.000 70.20298 ? 450 THR   A CB  1 
ATOM   1949 O OG1 . THR   A 1 254 ? 26.39200  -20.81200 -33.16400 1.000 72.31489 ? 450 THR   A OG1 1 
ATOM   1950 C CG2 . THR   A 1 254 ? 28.13300  -22.02700 -32.03500 1.000 67.50679 ? 450 THR   A CG2 1 
ATOM   1951 N N   . GLU   A 1 255 ? 27.66300  -17.27300 -32.94000 1.000 70.06882 ? 451 GLU   A N   1 
ATOM   1952 C CA  . GLU   A 1 255 ? 27.22600  -16.13100 -33.74200 1.000 72.67566 ? 451 GLU   A CA  1 
ATOM   1953 C C   . GLU   A 1 255 ? 28.05500  -14.91200 -33.36500 1.000 75.19654 ? 451 GLU   A C   1 
ATOM   1954 O O   . GLU   A 1 255 ? 27.92300  -14.38200 -32.25700 1.000 77.77376 ? 451 GLU   A O   1 
ATOM   1955 C CB  . GLU   A 1 255 ? 25.73200  -15.86000 -33.56700 1.000 72.13177 ? 451 GLU   A CB  1 
ATOM   1956 C CG  . GLU   A 1 255 ? 24.84200  -16.95400 -34.14200 1.000 69.20917 ? 451 GLU   A CG  1 
ATOM   1957 C CD  . GLU   A 1 255 ? 24.86800  -16.98600 -35.66200 1.000 68.52269 ? 451 GLU   A CD  1 
ATOM   1958 O OE1 . GLU   A 1 255 ? 24.46000  -18.01400 -36.24500 1.000 65.18900 ? 451 GLU   A OE1 1 
ATOM   1959 O OE2 . GLU   A 1 255 ? 25.28800  -15.98100 -36.27500 1.000 69.30203 ? 451 GLU   A OE2 1 
ATOM   1960 N N   . SER   A 1 256 ? 28.89800  -14.46600 -34.29800 1.000 78.25650 ? 452 SER   A N   1 
ATOM   1961 C CA  . SER   A 1 256 ? 29.82600  -13.37500 -34.02300 1.000 80.34013 ? 452 SER   A CA  1 
ATOM   1962 C C   . SER   A 1 256 ? 29.08500  -12.06700 -33.77100 1.000 81.31344 ? 452 SER   A C   1 
ATOM   1963 O O   . SER   A 1 256 ? 29.18500  -11.47800 -32.68900 1.000 83.12799 ? 452 SER   A O   1 
ATOM   1964 C CB  . SER   A 1 256 ? 30.80400  -13.22500 -35.18900 1.000 80.59753 ? 452 SER   A CB  1 
ATOM   1965 O OG  . SER   A 1 256 ? 30.14400  -13.40700 -36.43100 1.000 82.52857 ? 452 SER   A OG  1 
ATOM   1966 N N   . ASP   A 1 257 ? 28.33200  -11.59800 -34.76300 1.000 78.92623 ? 453 ASP   A N   1 
ATOM   1967 C CA  . ASP   A 1 257 ? 27.70000  -10.28100 -34.70300 1.000 77.48063 ? 453 ASP   A CA  1 
ATOM   1968 C C   . ASP   A 1 257 ? 26.29300  -10.33000 -34.12600 1.000 76.04380 ? 453 ASP   A C   1 
ATOM   1969 O O   . ASP   A 1 257 ? 25.38200  -9.66600  -34.63100 1.000 76.27564 ? 453 ASP   A O   1 
ATOM   1970 C CB  . ASP   A 1 257 ? 27.69600  -9.65800  -36.09500 1.000 78.23831 ? 453 ASP   A CB  1 
ATOM   1971 C CG  . ASP   A 1 257 ? 28.78000  -8.61200  -36.26500 1.000 85.73609 ? 453 ASP   A CG  1 
ATOM   1972 O OD1 . ASP   A 1 257 ? 29.56300  -8.71800  -37.23400 1.000 85.58526 ? 453 ASP   A OD1 1 
ATOM   1973 O OD2 . ASP   A 1 257 ? 28.85400  -7.68700  -35.42800 1.000 82.30307 ? 453 ASP   A OD2 1 
ATOM   1974 N N   . ALA   A 1 258 ? 26.08600  -11.10900 -33.06500 1.000 74.10115 ? 454 ALA   A N   1 
ATOM   1975 C CA  . ALA   A 1 258 ? 24.79600  -11.20200 -32.38700 1.000 73.88961 ? 454 ALA   A CA  1 
ATOM   1976 C C   . ALA   A 1 258 ? 25.00900  -11.02300 -30.88300 1.000 70.38838 ? 454 ALA   A C   1 
ATOM   1977 O O   . ALA   A 1 258 ? 24.76700  -11.92300 -30.07800 1.000 69.60457 ? 454 ALA   A O   1 
ATOM   1978 C CB  . ALA   A 1 258 ? 24.10300  -12.52800 -32.69700 1.000 70.85241 ? 454 ALA   A CB  1 
ATOM   1979 N N   . ALA   A 1 259 ? 25.47200  -9.83400  -30.50500 1.000 68.80282 ? 455 ALA   A N   1 
ATOM   1980 C CA  . ALA   A 1 259 ? 25.81500  -9.56900  -29.11600 1.000 64.58238 ? 455 ALA   A CA  1 
ATOM   1981 C C   . ALA   A 1 259 ? 24.56100  -9.49900  -28.25300 1.000 66.89490 ? 455 ALA   A C   1 
ATOM   1982 O O   . ALA   A 1 259 ? 23.62100  -8.76000  -28.56100 1.000 65.09724 ? 455 ALA   A O   1 
ATOM   1983 C CB  . ALA   A 1 259 ? 26.60400  -8.26500  -29.00600 1.000 67.79447 ? 455 ALA   A CB  1 
ATOM   1984 N N   . LEU   A 1 260 ? 24.55200  -10.27000 -27.16900 1.000 67.90401 ? 456 LEU   A N   1 
ATOM   1985 C CA  . LEU   A 1 260 ? 23.44700  -10.22000 -26.22400 1.000 61.61183 ? 456 LEU   A CA  1 
ATOM   1986 C C   . LEU   A 1 260 ? 23.50100  -8.94300  -25.39600 1.000 63.45441 ? 456 LEU   A C   1 
ATOM   1987 O O   . LEU   A 1 260 ? 24.56500  -8.52500  -24.93300 1.000 62.93680 ? 456 LEU   A O   1 
ATOM   1988 C CB  . LEU   A 1 260 ? 23.47600  -11.44100 -25.30800 1.000 64.52459 ? 456 LEU   A CB  1 
ATOM   1989 C CG  . LEU   A 1 260 ? 22.78600  -12.70200 -25.82900 1.000 64.68414 ? 456 LEU   A CG  1 
ATOM   1990 C CD1 . LEU   A 1 260 ? 23.79000  -13.63400 -26.47500 1.000 65.47969 ? 456 LEU   A CD1 1 
ATOM   1991 C CD2 . LEU   A 1 260 ? 22.06100  -13.40600 -24.68700 1.000 65.02059 ? 456 LEU   A CD2 1 
ATOM   1992 N N   . HIS   A 1 261 ? 22.34000  -8.32200  -25.22300 1.000 59.26201 ? 457 HIS   A N   1 
ATOM   1993 C CA  . HIS   A 1 261 ? 22.23100  -7.16600  -24.34900 1.000 58.07553 ? 457 HIS   A CA  1 
ATOM   1994 C C   . HIS   A 1 261 ? 22.61600  -7.57200  -22.92600 1.000 59.14549 ? 457 HIS   A C   1 
ATOM   1995 O O   . HIS   A 1 261 ? 22.29200  -8.68500  -22.49100 1.000 57.51573 ? 457 HIS   A O   1 
ATOM   1996 C CB  . HIS   A 1 261 ? 20.80000  -6.61900  -24.40300 1.000 57.96366 ? 457 HIS   A CB  1 
ATOM   1997 C CG  . HIS   A 1 261 ? 20.59300  -5.34300  -23.64700 1.000 53.60116 ? 457 HIS   A CG  1 
ATOM   1998 N ND1 . HIS   A 1 261 ? 20.70100  -5.25800  -22.27600 1.000 57.28480 ? 457 HIS   A ND1 1 
ATOM   1999 C CD2 . HIS   A 1 261 ? 20.26400  -4.10100  -24.07400 1.000 49.65906 ? 457 HIS   A CD2 1 
ATOM   2000 C CE1 . HIS   A 1 261 ? 20.45900  -4.01800  -21.89100 1.000 51.26711 ? 457 HIS   A CE1 1 
ATOM   2001 N NE2 . HIS   A 1 261 ? 20.18900  -3.29600  -22.96300 1.000 53.13549 ? 457 HIS   A NE2 1 
ATOM   2002 N N   . PRO   A 1 262 ? 23.33100  -6.71500  -22.18400 1.000 57.68545 ? 458 PRO   A N   1 
ATOM   2003 C CA  . PRO   A 1 262 ? 23.79000  -7.12700  -20.84100 1.000 60.27036 ? 458 PRO   A CA  1 
ATOM   2004 C C   . PRO   A 1 262 ? 22.66600  -7.51700  -19.89200 1.000 60.26512 ? 458 PRO   A C   1 
ATOM   2005 O O   . PRO   A 1 262 ? 22.83400  -8.45800  -19.10500 1.000 57.90682 ? 458 PRO   A O   1 
ATOM   2006 C CB  . PRO   A 1 262 ? 24.56800  -5.90600  -20.32500 1.000 58.37439 ? 458 PRO   A CB  1 
ATOM   2007 C CG  . PRO   A 1 262 ? 24.66500  -4.94500  -21.44400 1.000 58.16230 ? 458 PRO   A CG  1 
ATOM   2008 C CD  . PRO   A 1 262 ? 23.86700  -5.41200  -22.61200 1.000 58.58698 ? 458 PRO   A CD  1 
ATOM   2009 N N   . LEU   A 1 263 ? 21.52200  -6.82600  -19.94000 1.000 58.34083 ? 459 LEU   A N   1 
ATOM   2010 C CA  . LEU   A 1 263 ? 20.41100  -7.19300  -19.06800 1.000 54.57954 ? 459 LEU   A CA  1 
ATOM   2011 C C   . LEU   A 1 263 ? 19.92100  -8.60600  -19.34900 1.000 52.29478 ? 459 LEU   A C   1 
ATOM   2012 O O   . LEU   A 1 263 ? 19.49800  -9.31200  -18.42600 1.000 55.24939 ? 459 LEU   A O   1 
ATOM   2013 C CB  . LEU   A 1 263 ? 19.26300  -6.19000  -19.21600 1.000 52.59796 ? 459 LEU   A CB  1 
ATOM   2014 C CG  . LEU   A 1 263 ? 17.96700  -6.51600  -18.46300 1.000 53.28872 ? 459 LEU   A CG  1 
ATOM   2015 C CD1 . LEU   A 1 263 ? 18.19600  -6.54100  -16.95800 1.000 53.68979 ? 459 LEU   A CD1 1 
ATOM   2016 C CD2 . LEU   A 1 263 ? 16.87200  -5.52500  -18.82100 1.000 50.60622 ? 459 LEU   A CD2 1 
ATOM   2017 N N   . LEU   A 1 264 ? 19.99300  -9.04800  -20.60300 1.000 52.07283 ? 460 LEU   A N   1 
ATOM   2018 C CA  . LEU   A 1 264 ? 19.48500  -10.37200 -20.93300 1.000 56.56407 ? 460 LEU   A CA  1 
ATOM   2019 C C   . LEU   A 1 264 ? 20.46800  -11.48000 -20.56800 1.000 56.58490 ? 460 LEU   A C   1 
ATOM   2020 O O   . LEU   A 1 264 ? 20.03500  -12.58200 -20.21300 1.000 55.11233 ? 460 LEU   A O   1 
ATOM   2021 C CB  . LEU   A 1 264 ? 19.11800  -10.44000 -22.41500 1.000 52.87997 ? 460 LEU   A CB  1 
ATOM   2022 C CG  . LEU   A 1 264 ? 18.12900  -9.36300  -22.87500 1.000 53.56426 ? 460 LEU   A CG  1 
ATOM   2023 C CD1 . LEU   A 1 264 ? 17.63700  -9.64100  -24.29100 1.000 52.60200 ? 460 LEU   A CD1 1 
ATOM   2024 C CD2 . LEU   A 1 264 ? 16.95600  -9.25400  -21.91000 1.000 47.86089 ? 460 LEU   A CD2 1 
ATOM   2025 N N   . GLN   A 1 265 ? 21.78100  -11.22900 -20.63100 1.000 57.90992 ? 461 GLN   A N   1 
ATOM   2026 C CA  . GLN   A 1 265 ? 22.70200  -12.27400 -20.18900 1.000 61.44437 ? 461 GLN   A CA  1 
ATOM   2027 C C   . GLN   A 1 265 ? 22.66500  -12.44300 -18.67700 1.000 58.73577 ? 461 GLN   A C   1 
ATOM   2028 O O   . GLN   A 1 265 ? 22.89100  -13.55100 -18.17600 1.000 62.21816 ? 461 GLN   A O   1 
ATOM   2029 C CB  . GLN   A 1 265 ? 24.13900  -12.00300 -20.64600 1.000 64.56306 ? 461 GLN   A CB  1 
ATOM   2030 C CG  . GLN   A 1 265 ? 24.51700  -10.56400 -20.89200 1.000 64.81048 ? 461 GLN   A CG  1 
ATOM   2031 C CD  . GLN   A 1 265 ? 25.94100  -10.44000 -21.40400 1.000 69.01526 ? 461 GLN   A CD  1 
ATOM   2032 O OE1 . GLN   A 1 265 ? 26.29800  -11.02300 -22.43000 1.000 67.76246 ? 461 GLN   A OE1 1 
ATOM   2033 N NE2 . GLN   A 1 265 ? 26.76600  -9.68900  -20.68100 1.000 69.53417 ? 461 GLN   A NE2 1 
ATOM   2034 N N   . GLU   A 1 266 ? 22.39300  -11.36600 -17.93600 1.000 55.13925 ? 462 GLU   A N   1 
ATOM   2035 C CA  . GLU   A 1 266 ? 22.15000  -11.50600 -16.50600 1.000 57.84993 ? 462 GLU   A CA  1 
ATOM   2036 C C   . GLU   A 1 266 ? 20.94300  -12.39800 -16.24600 1.000 58.71960 ? 462 GLU   A C   1 
ATOM   2037 O O   . GLU   A 1 266 ? 20.97200  -13.25200 -15.35000 1.000 56.12508 ? 462 GLU   A O   1 
ATOM   2038 C CB  . GLU   A 1 266 ? 21.94700  -10.13300 -15.86800 1.000 60.23715 ? 462 GLU   A CB  1 
ATOM   2039 C CG  . GLU   A 1 266 ? 21.51300  -10.18900 -14.41300 1.000 57.46652 ? 462 GLU   A CG  1 
ATOM   2040 C CD  . GLU   A 1 266 ? 21.48600  -8.82200  -13.76300 1.000 58.04246 ? 462 GLU   A CD  1 
ATOM   2041 O OE1 . GLU   A 1 266 ? 22.26500  -7.94300  -14.18900 1.000 62.57032 ? 462 GLU   A OE1 1 
ATOM   2042 O OE2 . GLU   A 1 266 ? 20.67300  -8.62000  -12.83700 1.000 58.81506 ? 462 GLU   A OE2 1 
ATOM   2043 N N   . ILE   A 1 267 ? 19.87400  -12.21500 -17.02500 1.000 52.20962 ? 463 ILE   A N   1 
ATOM   2044 C CA  . ILE   A 1 267 ? 18.68200  -13.04500 -16.87400 1.000 53.85038 ? 463 ILE   A CA  1 
ATOM   2045 C C   . ILE   A 1 267 ? 19.01000  -14.50200 -17.18000 1.000 55.00283 ? 463 ILE   A C   1 
ATOM   2046 O O   . ILE   A 1 267 ? 18.61400  -15.41600 -16.44700 1.000 57.05050 ? 463 ILE   A O   1 
ATOM   2047 C CB  . ILE   A 1 267 ? 17.54800  -12.52200 -17.77600 1.000 50.53994 ? 463 ILE   A CB  1 
ATOM   2048 C CG1 . ILE   A 1 267 ? 16.99800  -11.19900 -17.24000 1.000 46.20173 ? 463 ILE   A CG1 1 
ATOM   2049 C CG2 . ILE   A 1 267 ? 16.43100  -13.55500 -17.89500 1.000 44.33742 ? 463 ILE   A CG2 1 
ATOM   2050 C CD1 . ILE   A 1 267 ? 16.02600  -10.51900 -18.17800 1.000 45.63115 ? 463 ILE   A CD1 1 
ATOM   2051 N N   . TYR   A 1 268 ? 19.75500  -14.73600 -18.25700 1.000 53.45435 ? 464 TYR   A N   1 
ATOM   2052 C CA  . TYR   A 1 268 ? 20.04600  -16.08500 -18.72500 1.000 57.10580 ? 464 TYR   A CA  1 
ATOM   2053 C C   . TYR   A 1 268 ? 21.23700  -16.73600 -18.02700 1.000 58.18707 ? 464 TYR   A C   1 
ATOM   2054 O O   . TYR   A 1 268 ? 21.58500  -17.86700 -18.38100 1.000 64.93143 ? 464 TYR   A O   1 
ATOM   2055 C CB  . TYR   A 1 268 ? 20.30600  -16.06300 -20.23400 1.000 54.91500 ? 464 TYR   A CB  1 
ATOM   2056 C CG  . TYR   A 1 268 ? 19.06400  -15.95100 -21.09000 1.000 52.36824 ? 464 TYR   A CG  1 
ATOM   2057 C CD1 . TYR   A 1 268 ? 18.10600  -16.95400 -21.09700 1.000 51.86617 ? 464 TYR   A CD1 1 
ATOM   2058 C CD2 . TYR   A 1 268 ? 18.85600  -14.84300 -21.90100 1.000 49.90454 ? 464 TYR   A CD2 1 
ATOM   2059 C CE1 . TYR   A 1 268 ? 16.96900  -16.85500 -21.88600 1.000 46.33285 ? 464 TYR   A CE1 1 
ATOM   2060 C CE2 . TYR   A 1 268 ? 17.72500  -14.73400 -22.69200 1.000 48.61615 ? 464 TYR   A CE2 1 
ATOM   2061 C CZ  . TYR   A 1 268 ? 16.78400  -15.74200 -22.68200 1.000 48.87846 ? 464 TYR   A CZ  1 
ATOM   2062 O OH  . TYR   A 1 268 ? 15.65900  -15.63600 -23.47100 1.000 49.55796 ? 464 TYR   A OH  1 
ATOM   2063 N N   . ARG   A 1 269 ? 21.86100  -16.07000 -17.05200 1.000 61.63359 ? 465 ARG   A N   1 
ATOM   2064 C CA  . ARG   A 1 269 ? 23.14600  -16.54300 -16.53700 1.000 66.63179 ? 465 ARG   A CA  1 
ATOM   2065 C C   . ARG   A 1 269 ? 23.06400  -17.94500 -15.94400 1.000 75.68464 ? 465 ARG   A C   1 
ATOM   2066 O O   . ARG   A 1 269 ? 24.00500  -18.73700 -16.08500 1.000 80.14193 ? 465 ARG   A O   1 
ATOM   2067 C CB  . ARG   A 1 269 ? 23.70000  -15.56400 -15.50400 1.000 67.20167 ? 465 ARG   A CB  1 
ATOM   2068 C CG  . ARG   A 1 269 ? 25.21100  -15.42200 -15.58200 1.000 68.69760 ? 465 ARG   A CG  1 
ATOM   2069 C CD  . ARG   A 1 269 ? 25.70900  -14.13400 -14.95900 1.000 67.33117 ? 465 ARG   A CD  1 
ATOM   2070 N NE  . ARG   A 1 269 ? 26.09000  -13.17200 -15.98700 1.000 67.20221 ? 465 ARG   A NE  1 
ATOM   2071 C CZ  . ARG   A 1 269 ? 25.99000  -11.85600 -15.85900 1.000 69.53416 ? 465 ARG   A CZ  1 
ATOM   2072 N NH1 . ARG   A 1 269 ? 25.51700  -11.30300 -14.75500 1.000 65.26230 ? 465 ARG   A NH1 1 
ATOM   2073 N NH2 . ARG   A 1 269 ? 26.37500  -11.07600 -16.86500 1.000 67.27463 ? 465 ARG   A NH2 1 
ATOM   2074 N N   . ASP   A 1 270 ? 21.96000  -18.28100 -15.27600 1.000 73.05403 ? 466 ASP   A N   1 
ATOM   2075 C CA  . ASP   A 1 270 ? 21.88100  -19.54500 -14.55300 1.000 81.05024 ? 466 ASP   A CA  1 
ATOM   2076 C C   . ASP   A 1 270 ? 20.48200  -20.15700 -14.66300 1.000 79.72619 ? 466 ASP   A C   1 
ATOM   2077 O O   . ASP   A 1 270 ? 19.78300  -20.36600 -13.67700 1.000 83.46736 ? 466 ASP   A O   1 
ATOM   2078 C CB  . ASP   A 1 270 ? 22.28500  -19.33900 -13.09300 1.000 82.31109 ? 466 ASP   A CB  1 
ATOM   2079 C CG  . ASP   A 1 270 ? 23.78800  -19.25800 -12.91000 1.000 80.23786 ? 466 ASP   A CG  1 
ATOM   2080 O OD1 . ASP   A 1 270 ? 24.46900  -20.28400 -13.13900 1.000 78.72475 ? 466 ASP   A OD1 1 
ATOM   2081 O OD2 . ASP   A 1 270 ? 24.29400  -18.17700 -12.54700 1.000 79.20117 ? 466 ASP   A OD2 1 
ATOM   2082 N N   . MET   A 1 271 ? 20.06800  -20.46600 -15.88700 1.000 78.17029 ? 467 MET   A N   1 
ATOM   2083 C CA  . MET   A 1 271 ? 18.83000  -21.21100 -16.10500 1.000 79.24788 ? 467 MET   A CA  1 
ATOM   2084 C C   . MET   A 1 271 ? 19.11800  -22.54600 -16.78000 1.000 81.55500 ? 467 MET   A C   1 
ATOM   2085 O O   . MET   A 1 271 ? 18.75700  -22.75400 -17.93900 1.000 79.53902 ? 467 MET   A O   1 
ATOM   2086 C CB  . MET   A 1 271 ? 17.83600  -20.41000 -16.94900 1.000 80.35628 ? 467 MET   A CB  1 
ATOM   2087 C CG  . MET   A 1 271 ? 17.71900  -18.94300 -16.58600 1.000 75.22535 ? 467 MET   A CG  1 
ATOM   2088 S SD  . MET   A 1 271 ? 16.15300  -18.25600 -17.16100 1.000 76.43739 ? 467 MET   A SD  1 
ATOM   2089 C CE  . MET   A 1 271 ? 16.17700  -18.77300 -18.87600 1.000 64.44653 ? 467 MET   A CE  1 
ATOM   2090 N N   . PRO   B 2 7   ? 26.21400  -2.57400  -9.38600  1.000 77.50111 ? 141 PRO   B N   1 
ATOM   2091 C CA  . PRO   B 2 7   ? 25.40400  -3.76200  -9.09600  1.000 74.86877 ? 141 PRO   B CA  1 
ATOM   2092 C C   . PRO   B 2 7   ? 24.86100  -4.43900  -10.35300 1.000 75.34782 ? 141 PRO   B C   1 
ATOM   2093 O O   . PRO   B 2 7   ? 25.27400  -4.11500  -11.46900 1.000 75.38413 ? 141 PRO   B O   1 
ATOM   2094 C CB  . PRO   B 2 7   ? 24.25900  -3.20300  -8.25100  1.000 76.30090 ? 141 PRO   B CB  1 
ATOM   2095 C CG  . PRO   B 2 7   ? 24.84900  -2.01500  -7.56800  1.000 77.36081 ? 141 PRO   B CG  1 
ATOM   2096 C CD  . PRO   B 2 7   ? 25.86000  -1.43300  -8.52100  1.000 76.74414 ? 141 PRO   B CD  1 
ATOM   2097 N N   . SER   B 2 8   ? 23.93800  -5.37700  -10.16000 1.000 71.89406 ? 142 SER   B N   1 
ATOM   2098 C CA  . SER   B 2 8   ? 23.34400  -6.10500  -11.27000 1.000 64.38407 ? 142 SER   B CA  1 
ATOM   2099 C C   . SER   B 2 8   ? 22.20400  -5.30200  -11.88200 1.000 57.82626 ? 142 SER   B C   1 
ATOM   2100 O O   . SER   B 2 8   ? 21.57800  -4.47100  -11.22000 1.000 56.16380 ? 142 SER   B O   1 
ATOM   2101 C CB  . SER   B 2 8   ? 22.82700  -7.46600  -10.80800 1.000 65.13356 ? 142 SER   B CB  1 
ATOM   2102 O OG  . SER   B 2 8   ? 21.45700  -7.39200  -10.45300 1.000 60.77146 ? 142 SER   B OG  1 
ATOM   2103 N N   . LEU   B 2 9   ? 21.92000  -5.58200  -13.15600 1.000 59.47386 ? 143 LEU   B N   1 
ATOM   2104 C CA  . LEU   B 2 9   ? 20.98100  -4.75500  -13.90800 1.000 57.74144 ? 143 LEU   B CA  1 
ATOM   2105 C C   . LEU   B 2 9   ? 19.53900  -4.93300  -13.44000 1.000 52.82095 ? 143 LEU   B C   1 
ATOM   2106 O O   . LEU   B 2 9   ? 18.74400  -3.99000  -13.52500 1.000 50.13971 ? 143 LEU   B O   1 
ATOM   2107 C CB  . LEU   B 2 9   ? 21.10700  -5.05900  -15.40100 1.000 59.87218 ? 143 LEU   B CB  1 
ATOM   2108 C CG  . LEU   B 2 9   ? 22.47100  -4.70900  -16.00100 1.000 61.18312 ? 143 LEU   B CG  1 
ATOM   2109 C CD1 . LEU   B 2 9   ? 22.42200  -4.70400  -17.51700 1.000 54.05612 ? 143 LEU   B CD1 1 
ATOM   2110 C CD2 . LEU   B 2 9   ? 22.94000  -3.36000  -15.48200 1.000 54.83838 ? 143 LEU   B CD2 1 
ATOM   2111 N N   . LEU   B 2 10  ? 19.17400  -6.12000  -12.94900 1.000 55.42737 ? 144 LEU   B N   1 
ATOM   2112 C CA  . LEU   B 2 10  ? 17.81200  -6.30600  -12.45400 1.000 51.70787 ? 144 LEU   B CA  1 
ATOM   2113 C C   . LEU   B 2 10  ? 17.58100  -5.53100  -11.16000 1.000 55.04709 ? 144 LEU   B C   1 
ATOM   2114 O O   . LEU   B 2 10  ? 16.48400  -5.00600  -10.93300 1.000 50.78241 ? 144 LEU   B O   1 
ATOM   2115 C CB  . LEU   B 2 10  ? 17.51500  -7.79400  -12.26200 1.000 49.46341 ? 144 LEU   B CB  1 
ATOM   2116 C CG  . LEU   B 2 10  ? 17.21300  -8.56000  -13.55600 1.000 52.28164 ? 144 LEU   B CG  1 
ATOM   2117 C CD1 . LEU   B 2 10  ? 17.32400  -10.06600 -13.35000 1.000 48.77713 ? 144 LEU   B CD1 1 
ATOM   2118 C CD2 . LEU   B 2 10  ? 15.83800  -8.18500  -14.10000 1.000 50.32032 ? 144 LEU   B CD2 1 
ATOM   2119 N N   . LYS   B 2 11  ? 18.59700  -5.44300  -10.31600 1.000 52.21733 ? 145 LYS   B N   1 
ATOM   2120 C CA  . LYS   B 2 11  ? 18.47100  -4.69000  -9.10000  1.000 53.22286 ? 145 LYS   B CA  1 
ATOM   2121 C C   . LYS   B 2 11  ? 18.17400  -3.24700  -9.43500  1.000 54.64328 ? 145 LYS   B C   1 
ATOM   2122 O O   . LYS   B 2 11  ? 17.32400  -2.64400  -8.84900  1.000 55.28368 ? 145 LYS   B O   1 
ATOM   2123 C CB  . LYS   B 2 11  ? 19.74500  -4.76300  -8.28700  1.000 55.09567 ? 145 LYS   B CB  1 
ATOM   2124 C CG  . LYS   B 2 11  ? 20.10400  -6.14900  -7.82100  1.000 62.31593 ? 145 LYS   B CG  1 
ATOM   2125 C CD  . LYS   B 2 11  ? 20.59200  -6.13900  -6.38300  1.000 60.66091 ? 145 LYS   B CD  1 
ATOM   2126 C CE  . LYS   B 2 11  ? 20.93300  -7.53800  -5.92400  1.000 61.31614 ? 145 LYS   B CE  1 
ATOM   2127 N NZ  . LYS   B 2 11  ? 21.54200  -7.59300  -4.57300  1.000 61.68443 ? 145 LYS   B NZ  1 
ATOM   2128 N N   . LYS   B 2 12  ? 18.87600  -2.69600  -10.40500 1.000 53.06639 ? 146 LYS   B N   1 
ATOM   2129 C CA  . LYS   B 2 12  ? 18.66200  -1.30700  -10.76900 1.000 54.58146 ? 146 LYS   B CA  1 
ATOM   2130 C C   . LYS   B 2 12  ? 17.25400  -1.02900  -11.22700 1.000 53.66659 ? 146 LYS   B C   1 
ATOM   2131 O O   . LYS   B 2 12  ? 16.71200  -0.00900  -10.90400 1.000 56.29123 ? 146 LYS   B O   1 
ATOM   2132 C CB  . LYS   B 2 12  ? 19.67500  -0.83200  -11.79900 1.000 52.25689 ? 146 LYS   B CB  1 
ATOM   2133 C CG  . LYS   B 2 12  ? 20.96200  -1.61400  -11.78000 1.000 58.31617 ? 146 LYS   B CG  1 
ATOM   2134 C CD  . LYS   B 2 12  ? 21.87200  -1.19700  -10.65300 1.000 63.05228 ? 146 LYS   B CD  1 
ATOM   2135 C CE  . LYS   B 2 12  ? 22.77000  -0.05900  -11.09700 1.000 69.20034 ? 146 LYS   B CE  1 
ATOM   2136 N NZ  . LYS   B 2 12  ? 22.90700  -0.01600  -12.57600 1.000 67.33124 ? 146 LYS   B NZ  1 
ATOM   2137 N N   . LEU   B 2 13  ? 16.66400  -1.93500  -11.98400 1.000 53.92842 ? 147 LEU   B N   1 
ATOM   2138 C CA  . LEU   B 2 13  ? 15.30300  -1.74600  -12.41800 1.000 51.89514 ? 147 LEU   B CA  1 
ATOM   2139 C C   . LEU   B 2 13  ? 14.40100  -1.79000  -11.23200 1.000 53.17208 ? 147 LEU   B C   1 
ATOM   2140 O O   . LEU   B 2 13  ? 13.46200  -1.06500  -11.17300 1.000 55.63401 ? 147 LEU   B O   1 
ATOM   2141 C CB  . LEU   B 2 13  ? 14.88600  -2.83000  -13.37000 1.000 51.08377 ? 147 LEU   B CB  1 
ATOM   2142 C CG  . LEU   B 2 13  ? 15.46900  -2.79200  -14.75800 1.000 52.40156 ? 147 LEU   B CG  1 
ATOM   2143 C CD1 . LEU   B 2 13  ? 14.96500  -3.98100  -15.51700 1.000 48.93849 ? 147 LEU   B CD1 1 
ATOM   2144 C CD2 . LEU   B 2 13  ? 15.05200  -1.52100  -15.43300 1.000 48.11623 ? 147 LEU   B CD2 1 
ATOM   2145 N N   . LEU   B 2 14  ? 14.69700  -2.63500  -10.26500 1.000 51.71561 ? 148 LEU   B N   1 
ATOM   2146 C CA  . LEU   B 2 14  ? 13.81500  -2.71800  -9.10700  1.000 50.99775 ? 148 LEU   B CA  1 
ATOM   2147 C C   . LEU   B 2 14  ? 13.95700  -1.51000  -8.19000  1.000 57.13170 ? 148 LEU   B C   1 
ATOM   2148 O O   . LEU   B 2 14  ? 12.98100  -1.11000  -7.54500  1.000 60.96543 ? 148 LEU   B O   1 
ATOM   2149 C CB  . LEU   B 2 14  ? 14.08300  -4.01000  -8.33600  1.000 51.89740 ? 148 LEU   B CB  1 
ATOM   2150 C CG  . LEU   B 2 14  ? 13.44300  -5.26200  -8.94100  1.000 49.02657 ? 148 LEU   B CG  1 
ATOM   2151 C CD1 . LEU   B 2 14  ? 14.20700  -6.51400  -8.54600  1.000 46.77154 ? 148 LEU   B CD1 1 
ATOM   2152 C CD2 . LEU   B 2 14  ? 11.98600  -5.36300  -8.51200  1.000 46.61840 ? 148 LEU   B CD2 1 
ATOM   2153 N N   . LEU   B 2 15  ? 15.14500  -0.91700  -8.11300  1.000 56.31640 ? 149 LEU   B N   1 
ATOM   2154 C CA  . LEU   B 2 15  ? 15.36500  0.21600   -7.22400  1.000 62.37631 ? 149 LEU   B CA  1 
ATOM   2155 C C   . LEU   B 2 15  ? 15.09300  1.56100   -7.88600  1.000 65.87918 ? 149 LEU   B C   1 
ATOM   2156 O O   . LEU   B 2 15  ? 15.23900  2.59700   -7.22800  1.000 68.37890 ? 149 LEU   B O   1 
ATOM   2157 C CB  . LEU   B 2 15  ? 16.79500  0.19100   -6.67800  1.000 60.11016 ? 149 LEU   B CB  1 
ATOM   2158 C CG  . LEU   B 2 15  ? 17.15800  -1.07200  -5.89500  1.000 58.16118 ? 149 LEU   B CG  1 
ATOM   2159 C CD1 . LEU   B 2 15  ? 18.66500  -1.20800  -5.74900  1.000 57.90986 ? 149 LEU   B CD1 1 
ATOM   2160 C CD2 . LEU   B 2 15  ? 16.47300  -1.08200  -4.54300  1.000 57.10187 ? 149 LEU   B CD2 1 
ATOM   2161 N N   . ALA   B 2 16  ? 14.69900  1.57400   -9.15800  1.000 64.40730 ? 150 ALA   B N   1 
ATOM   2162 C CA  . ALA   B 2 16  ? 14.43700  2.83100   -9.84000  1.000 69.36413 ? 150 ALA   B CA  1 
ATOM   2163 C C   . ALA   B 2 16  ? 13.23900  3.54100   -9.20800  1.000 77.30297 ? 150 ALA   B C   1 
ATOM   2164 O O   . ALA   B 2 16  ? 12.34900  2.89300   -8.64500  1.000 76.59215 ? 150 ALA   B O   1 
ATOM   2165 C CB  . ALA   B 2 16  ? 14.17600  2.59000   -11.32600 1.000 67.44513 ? 150 ALA   B CB  1 
ATOM   2166 N N   . PRO   B 2 17  ? 13.20400  4.88300   -9.26200  1.000 78.00804 ? 151 PRO   B N   1 
ATOM   2167 C CA  . PRO   B 2 17  ? 12.05000  5.67700   -8.82700  1.000 80.39845 ? 151 PRO   B CA  1 
ATOM   2168 C C   . PRO   B 2 17  ? 10.76300  5.28800   -9.55100  1.000 78.74676 ? 151 PRO   B C   1 
ATOM   2169 O O   . PRO   B 2 17  ? 10.04500  4.41000   -9.07300  1.000 75.73242 ? 151 PRO   B O   1 
ATOM   2170 C CB  . PRO   B 2 17  ? 12.46100  7.10600   -9.18900  1.000 80.08164 ? 151 PRO   B CB  1 
ATOM   2171 C CG  . PRO   B 2 17  ? 13.94300  7.09700   -9.06900  1.000 81.49226 ? 151 PRO   B CG  1 
ATOM   2172 C CD  . PRO   B 2 17  ? 14.37800  5.73000   -9.54200  1.000 78.33765 ? 151 PRO   B CD  1 
HETATM 2173 C C10 . A1LZ1 C 3 .   ? 18.36400  -15.08100 -28.78000 1.000 48.22370 ? 500 A1LZ1 A C10 1 
HETATM 2174 C C11 . A1LZ1 C 3 .   ? 18.12500  -12.73400 -27.95600 1.000 46.23348 ? 500 A1LZ1 A C11 1 
HETATM 2175 C C12 . A1LZ1 C 3 .   ? 17.66800  -16.42800 -28.98500 1.000 46.27370 ? 500 A1LZ1 A C12 1 
HETATM 2176 C C16 . A1LZ1 C 3 .   ? 14.37000  -13.96100 -35.39000 1.000 50.41232 ? 500 A1LZ1 A C16 1 
HETATM 2177 C C01 . A1LZ1 C 3 .   ? 11.98200  -12.97000 -28.76500 1.000 46.30193 ? 500 A1LZ1 A C01 1 
HETATM 2178 C C02 . A1LZ1 C 3 .   ? 12.71800  -13.00900 -27.47900 1.000 45.12695 ? 500 A1LZ1 A C02 1 
HETATM 2179 C C03 . A1LZ1 C 3 .   ? 14.15600  -13.31100 -27.46100 1.000 43.46394 ? 500 A1LZ1 A C03 1 
HETATM 2180 C C04 . A1LZ1 C 3 .   ? 14.89500  -13.58400 -28.77800 1.000 48.57752 ? 500 A1LZ1 A C04 1 
HETATM 2181 C C05 . A1LZ1 C 3 .   ? 14.18500  -13.54200 -29.98000 1.000 49.57282 ? 500 A1LZ1 A C05 1 
HETATM 2182 C C06 . A1LZ1 C 3 .   ? 16.21100  -13.88500 -29.09500 1.000 49.43811 ? 500 A1LZ1 A C06 1 
HETATM 2183 C C08 . A1LZ1 C 3 .   ? 14.88900  -13.32500 -26.12400 1.000 45.68939 ? 500 A1LZ1 A C08 1 
HETATM 2184 C C09 . A1LZ1 C 3 .   ? 17.40500  -14.05900 -28.16200 1.000 48.07310 ? 500 A1LZ1 A C09 1 
HETATM 2185 C C13 . A1LZ1 C 3 .   ? 19.09400  -12.88500 -26.78600 1.000 51.79835 ? 500 A1LZ1 A C13 1 
HETATM 2186 C C14 . A1LZ1 C 3 .   ? 13.40700  -14.25400 -32.95200 1.000 48.75737 ? 500 A1LZ1 A C14 1 
HETATM 2187 C C15 . A1LZ1 C 3 .   ? 13.20900  -14.29600 -34.46000 1.000 46.71734 ? 500 A1LZ1 A C15 1 
HETATM 2188 C C17 . A1LZ1 C 3 .   ? 15.73400  -13.57800 -34.83300 1.000 50.59011 ? 500 A1LZ1 A C17 1 
HETATM 2189 C C18 . A1LZ1 C 3 .   ? 15.93200  -13.53300 -33.32600 1.000 48.67509 ? 500 A1LZ1 A C18 1 
HETATM 2190 C C19 . A1LZ1 C 3 .   ? 14.77300  -13.87200 -32.39500 1.000 48.29258 ? 500 A1LZ1 A C19 1 
HETATM 2191 C C26 . A1LZ1 C 3 .   ? 8.10200   -9.62400  -28.72500 1.000 41.37187 ? 500 A1LZ1 A C26 1 
HETATM 2192 C C27 . A1LZ1 C 3 .   ? 6.13700   -9.10900  -27.49300 1.000 43.49584 ? 500 A1LZ1 A C27 1 
HETATM 2193 C C28 . A1LZ1 C 3 .   ? 10.10500  -12.11500 -27.57000 1.000 40.46689 ? 500 A1LZ1 A C28 1 
HETATM 2194 C C29 . A1LZ1 C 3 .   ? 10.10300  -10.59000 -27.53900 1.000 37.92039 ? 500 A1LZ1 A C29 1 
HETATM 2195 C C31 . A1LZ1 C 3 .   ? 10.17500  -10.48400 -29.93900 1.000 43.41719 ? 500 A1LZ1 A C31 1 
HETATM 2196 C C32 . A1LZ1 C 3 .   ? 10.23000  -12.00600 -30.03000 1.000 42.53568 ? 500 A1LZ1 A C32 1 
HETATM 2197 C C35 . A1LZ1 C 3 .   ? 5.62200   -9.23300  -26.05800 1.000 38.51307 ? 500 A1LZ1 A C35 1 
HETATM 2198 C C36 . A1LZ1 C 3 .   ? 4.09600   -9.18100  -26.04400 1.000 43.83124 ? 500 A1LZ1 A C36 1 
HETATM 2199 C C37 . A1LZ1 C 3 .   ? 3.62500   -7.84800  -26.62800 1.000 47.49860 ? 500 A1LZ1 A C37 1 
HETATM 2200 F F20 . A1LZ1 C 3 .   ? 14.18300  -14.00000 -36.73400 1.000 50.02125 ? 500 A1LZ1 A F20 1 
HETATM 2201 N N07 . A1LZ1 C 3 .   ? 10.56300  -12.68300 -28.80900 1.000 48.89861 ? 500 A1LZ1 A N07 1 
HETATM 2202 N N21 . A1LZ1 C 3 .   ? 12.69600  -13.23200 -30.00900 1.000 46.38189 ? 500 A1LZ1 A N21 1 
HETATM 2203 N N22 . A1LZ1 C 3 .   ? 16.29800  -14.02000 -30.42800 1.000 45.90993 ? 500 A1LZ1 A N22 1 
HETATM 2204 N N23 . A1LZ1 C 3 .   ? 15.03500  -13.81500 -30.97600 1.000 49.57032 ? 500 A1LZ1 A N23 1 
HETATM 2205 N N30 . A1LZ1 C 3 .   ? 9.49600   -9.99900  -28.73100 1.000 44.90079 ? 500 A1LZ1 A N30 1 
HETATM 2206 O O24 . A1LZ1 C 3 .   ? 15.04800  -12.22800 -25.51600 1.000 47.21046 ? 500 A1LZ1 A O24 1 
HETATM 2207 O O25 . A1LZ1 C 3 .   ? 15.33900  -14.39500 -25.63900 1.000 45.81747 ? 500 A1LZ1 A O25 1 
HETATM 2208 O O33 . A1LZ1 C 3 .   ? 7.52700   -9.39700  -29.73500 1.000 40.82691 ? 500 A1LZ1 A O33 1 
HETATM 2209 O O34 . A1LZ1 C 3 .   ? 7.46400   -9.54300  -27.48700 1.000 40.77597 ? 500 A1LZ1 A O34 1 
HETATM 2210 O O   . HOH   D 4 .   ? 24.03500  -15.04900 -20.14800 1.000 66.41743 ? 601 HOH   A O   1 
HETATM 2211 O O   . HOH   D 4 .   ? 1.15300   -25.61300 -24.77200 1.000 49.54234 ? 602 HOH   A O   1 
HETATM 2212 O O   . HOH   D 4 .   ? -2.89900  2.10300   -23.24700 1.000 58.48581 ? 603 HOH   A O   1 
HETATM 2213 O O   . HOH   D 4 .   ? -10.55600 -6.84200  -7.21300  1.000 56.54892 ? 604 HOH   A O   1 
HETATM 2214 O O   . HOH   D 4 .   ? 3.62500   -29.02500 -19.60400 1.000 46.24198 ? 605 HOH   A O   1 
HETATM 2215 O O   . HOH   D 4 .   ? 11.22900  -20.26900 -16.61500 1.000 48.27678 ? 606 HOH   A O   1 
HETATM 2216 O O   . HOH   D 4 .   ? 7.09400   -25.72300 -33.22400 1.000 51.55434 ? 607 HOH   A O   1 
HETATM 2217 O O   . HOH   D 4 .   ? -12.36500 -24.79400 -14.03600 1.000 49.80773 ? 608 HOH   A O   1 
HETATM 2218 O O   . HOH   D 4 .   ? 6.51900   -7.46000  -30.96000 1.000 38.49136 ? 609 HOH   A O   1 
HETATM 2219 O O   . HOH   D 4 .   ? 4.33700   -5.33800  -47.36300 1.000 52.25480 ? 610 HOH   A O   1 
HETATM 2220 O O   . HOH   D 4 .   ? 4.14000   -4.38000  -4.31400  1.000 39.36623 ? 611 HOH   A O   1 
HETATM 2221 O O   . HOH   D 4 .   ? -5.46400  -3.03700  -39.15800 1.000 62.06298 ? 612 HOH   A O   1 
HETATM 2222 O O   . HOH   D 4 .   ? -12.31200 -21.54800 -11.85300 1.000 44.76321 ? 613 HOH   A O   1 
HETATM 2223 O O   . HOH   D 4 .   ? 11.29700  -11.71800 0.24900   1.000 49.66404 ? 614 HOH   A O   1 
HETATM 2224 O O   . HOH   D 4 .   ? 3.58000   -16.34400 -42.80400 1.000 45.83118 ? 615 HOH   A O   1 
HETATM 2225 O O   . HOH   D 4 .   ? -9.60600  -5.58000  -30.08300 1.000 50.03926 ? 616 HOH   A O   1 
HETATM 2226 O O   . HOH   D 4 .   ? -1.00500  -0.23600  -36.75100 1.000 47.41836 ? 617 HOH   A O   1 
HETATM 2227 O O   . HOH   D 4 .   ? 2.61300   0.97100   -11.76100 1.000 46.19525 ? 618 HOH   A O   1 
HETATM 2228 O O   . HOH   D 4 .   ? -3.86300  -26.76900 -21.29200 1.000 44.27745 ? 619 HOH   A O   1 
HETATM 2229 O O   . HOH   D 4 .   ? 8.86500   -15.94700 -11.06800 1.000 35.84970 ? 620 HOH   A O   1 
HETATM 2230 O O   . HOH   D 4 .   ? 15.74600  -25.61900 -28.11800 1.000 52.01059 ? 621 HOH   A O   1 
HETATM 2231 O O   . HOH   D 4 .   ? 4.96300   0.09600   -10.70100 1.000 40.92592 ? 622 HOH   A O   1 
HETATM 2232 O O   . HOH   D 4 .   ? 18.68400  -10.18700 1.45100   1.000 50.41733 ? 623 HOH   A O   1 
HETATM 2233 O O   . HOH   D 4 .   ? -7.84400  -15.43700 -28.51900 1.000 42.35304 ? 624 HOH   A O   1 
HETATM 2234 O O   . HOH   D 4 .   ? -1.546    5.464     -35.375   1.000 48.33614 ? 625 HOH   A O   1 
HETATM 2235 O O   . HOH   D 4 .   ? 16.57200  -15.23500 -3.81700  1.000 47.59120 ? 626 HOH   A O   1 
HETATM 2236 O O   . HOH   D 4 .   ? 7.90900   -26.73500 -25.93800 1.000 56.01712 ? 627 HOH   A O   1 
HETATM 2237 O O   . HOH   D 4 .   ? -3.90900  -14.90800 -25.68000 1.000 31.47598 ? 628 HOH   A O   1 
HETATM 2238 O O   . HOH   D 4 .   ? -0.64600  -10.47500 -2.27200  1.000 49.29964 ? 629 HOH   A O   1 
HETATM 2239 O O   . HOH   D 4 .   ? 11.15200  -24.84400 -28.42100 1.000 47.56810 ? 630 HOH   A O   1 
HETATM 2240 O O   . HOH   D 4 .   ? 12.72000  -15.75500 -17.41000 1.000 43.51960 ? 631 HOH   A O   1 
HETATM 2241 O O   . HOH   D 4 .   ? 2.51000   -3.90300  -46.04100 1.000 57.79739 ? 632 HOH   A O   1 
HETATM 2242 O O   . HOH   D 4 .   ? -1.02800  -1.56400  -7.58900  1.000 52.19211 ? 633 HOH   A O   1 
HETATM 2243 O O   . HOH   D 4 .   ? -12.38600 -20.56800 -23.01400 1.000 53.17238 ? 634 HOH   A O   1 
HETATM 2244 O O   . HOH   D 4 .   ? -14.31300 -21.25000 -16.18800 1.000 47.94047 ? 635 HOH   A O   1 
HETATM 2245 O O   . HOH   D 4 .   ? -0.99300  -9.70700  -23.43200 1.000 35.22618 ? 636 HOH   A O   1 
HETATM 2246 O O   . HOH   D 4 .   ? -1.48700  -27.88200 -23.15700 1.000 51.79335 ? 637 HOH   A O   1 
HETATM 2247 O O   . HOH   D 4 .   ? -2.38900  -1.47200  -4.94900  1.000 57.95819 ? 638 HOH   A O   1 
HETATM 2248 O O   . HOH   D 4 .   ? 7.32000   -27.81600 -17.47200 1.000 46.63012 ? 639 HOH   A O   1 
HETATM 2249 O O   . HOH   D 4 .   ? -9.60100  -9.62200  -5.83200  1.000 54.55622 ? 640 HOH   A O   1 
HETATM 2250 O O   . HOH   D 4 .   ? -0.59600  -23.42700 -25.66300 1.000 45.81876 ? 641 HOH   A O   1 
HETATM 2251 O O   . HOH   D 4 .   ? 11.13500  -22.20700 -27.26800 1.000 40.37945 ? 642 HOH   A O   1 
HETATM 2252 O O   . HOH   D 4 .   ? -1.87700  -2.97100  -21.33600 1.000 45.20107 ? 643 HOH   A O   1 
HETATM 2253 O O   . HOH   D 4 .   ? -2.64600  -1.25500  -9.53300  1.000 39.62913 ? 644 HOH   A O   1 
HETATM 2254 O O   . HOH   D 4 .   ? -6.05800  -1.29200  -23.67400 1.000 54.35065 ? 645 HOH   A O   1 
HETATM 2255 O O   . HOH   D 4 .   ? -5.25500  -20.82400 -4.73500  1.000 49.62858 ? 646 HOH   A O   1 
HETATM 2256 O O   . HOH   D 4 .   ? 14.16800  -21.93900 -2.51700  1.000 61.29227 ? 647 HOH   A O   1 
HETATM 2257 O O   . HOH   D 4 .   ? 2.19700   2.12900   -39.64400 1.000 48.51461 ? 648 HOH   A O   1 
HETATM 2258 O O   . HOH   D 4 .   ? 12.16000  6.44800   -37.92400 1.000 56.30239 ? 649 HOH   A O   1 
HETATM 2259 O O   . HOH   D 4 .   ? 5.61500   0.18800   -17.70900 1.000 43.42531 ? 650 HOH   A O   1 
HETATM 2260 O O   . HOH   D 4 .   ? 24.98800  -8.32400  -17.26600 1.000 60.53940 ? 651 HOH   A O   1 
HETATM 2261 O O   . HOH   D 4 .   ? -6.08500  -16.63000 -25.11600 1.000 35.36167 ? 652 HOH   A O   1 
HETATM 2262 O O   . HOH   D 4 .   ? 1.79800   -7.29600  -23.24300 1.000 41.98148 ? 653 HOH   A O   1 
HETATM 2263 O O   . HOH   D 4 .   ? 6.08600   -26.06600 -24.19400 1.000 45.21991 ? 654 HOH   A O   1 
HETATM 2264 O O   . HOH   D 4 .   ? -4.88100  -25.90200 -25.61300 1.000 47.47059 ? 655 HOH   A O   1 
HETATM 2265 O O   . HOH   D 4 .   ? -8.93200  -8.21500  -23.78500 1.000 42.45942 ? 656 HOH   A O   1 
HETATM 2266 O O   . HOH   D 4 .   ? -1.76400  -13.84700 -24.45800 1.000 32.77420 ? 657 HOH   A O   1 
HETATM 2267 O O   . HOH   D 4 .   ? -4.59900  1.42700   -14.90500 1.000 43.80696 ? 658 HOH   A O   1 
HETATM 2268 O O   . HOH   D 4 .   ? 4.45700   2.74200   -14.46600 1.000 50.57937 ? 659 HOH   A O   1 
HETATM 2269 O O   . HOH   D 4 .   ? 10.62500  -19.01100 -36.84600 1.000 48.07910 ? 660 HOH   A O   1 
HETATM 2270 O O   . HOH   D 4 .   ? 3.82400   -4.79100  -24.00900 1.000 46.20033 ? 661 HOH   A O   1 
HETATM 2271 O O   . HOH   D 4 .   ? 8.36400   -5.51100  -31.47200 1.000 45.59638 ? 662 HOH   A O   1 
HETATM 2272 O O   . HOH   D 4 .   ? 7.06700   -3.29800  -30.11100 1.000 43.39163 ? 663 HOH   A O   1 
HETATM 2273 O O   . HOH   D 4 .   ? -10.21800 -7.82700  -20.35400 1.000 40.23719 ? 664 HOH   A O   1 
HETATM 2274 O O   . HOH   D 4 .   ? 7.828     -28.887   -25.039   1.000 59.78660 ? 665 HOH   A O   1 
HETATM 2275 O O   . HOH   D 4 .   ? 11.43000  -11.62100 2.48900   1.000 49.71758 ? 666 HOH   A O   1 
HETATM 2276 O O   . HOH   D 4 .   ? -1.61800  -12.46500 -3.18200  1.000 43.25592 ? 667 HOH   A O   1 
HETATM 2277 O O   . HOH   D 4 .   ? 8.06600   -18.82200 -37.91700 1.000 43.65884 ? 668 HOH   A O   1 
HETATM 2278 O O   . HOH   D 4 .   ? 4.71400   -17.67400 -27.43100 1.000 33.81991 ? 669 HOH   A O   1 
HETATM 2279 O O   . HOH   D 4 .   ? 6.61800   -4.50800  -24.98800 1.000 52.52910 ? 670 HOH   A O   1 
HETATM 2280 O O   . HOH   D 4 .   ? -5.71300  -12.24900 -36.84700 1.000 50.09998 ? 671 HOH   A O   1 
HETATM 2281 O O   . HOH   D 4 .   ? 19.48700  -4.99900  -30.22300 1.000 61.73337 ? 672 HOH   A O   1 
HETATM 2282 O O   . HOH   D 4 .   ? -8.01600  -4.43400  -21.99100 1.000 46.52185 ? 673 HOH   A O   1 
HETATM 2283 O O   . HOH   D 4 .   ? 11.77100  -7.28000  2.95500   1.000 46.78774 ? 674 HOH   A O   1 
HETATM 2284 O O   . HOH   D 4 .   ? 15.58200  -4.00800  -37.94300 1.000 53.04636 ? 675 HOH   A O   1 
HETATM 2285 O O   . HOH   D 4 .   ? 0.20800   1.35800   -33.39900 1.000 48.29563 ? 676 HOH   A O   1 
HETATM 2286 O O   . HOH   D 4 .   ? 9.80100   -27.83500 -17.66200 1.000 54.88089 ? 677 HOH   A O   1 
HETATM 2287 O O   . HOH   D 4 .   ? 2.22100   -3.87200  -1.82800  1.000 55.95915 ? 678 HOH   A O   1 
HETATM 2288 O O   . HOH   D 4 .   ? 18.74500  -13.04300 -6.69400  1.000 50.29041 ? 679 HOH   A O   1 
HETATM 2289 O O   . HOH   D 4 .   ? -4.45000  -0.63200  -31.52100 1.000 43.87310 ? 680 HOH   A O   1 
HETATM 2290 O O   . HOH   D 4 .   ? -12.34400 -22.41900 -14.83400 1.000 46.65871 ? 681 HOH   A O   1 
HETATM 2291 O O   . HOH   D 4 .   ? 5.16600   -3.48000  -28.57200 1.000 48.65929 ? 682 HOH   A O   1 
HETATM 2292 O O   . HOH   D 4 .   ? -5.02900  -16.89400 -35.77800 1.000 52.73061 ? 683 HOH   A O   1 
HETATM 2293 O O   . HOH   D 4 .   ? 1.25200   -18.36800 -42.87400 1.000 56.23888 ? 684 HOH   A O   1 
HETATM 2294 O O   . HOH   D 4 .   ? 10.38100  -2.77800  -3.89600  1.000 58.70381 ? 685 HOH   A O   1 
HETATM 2295 O O   . HOH   D 4 .   ? 27.28500  -13.99600 -18.74800 1.000 66.97683 ? 686 HOH   A O   1 
HETATM 2296 O O   . HOH   D 4 .   ? 0.41500   -8.40000  -25.31800 1.000 44.99435 ? 687 HOH   A O   1 
HETATM 2297 O O   . HOH   D 4 .   ? 4.36800   -4.70200  -31.41400 1.000 47.05751 ? 688 HOH   A O   1 
HETATM 2298 O O   . HOH   D 4 .   ? -4.70400  -16.88900 -32.95700 1.000 51.62143 ? 689 HOH   A O   1 
HETATM 2299 O O   . HOH   D 4 .   ? 20.10900  -10.76800 -6.34400  1.000 50.72206 ? 690 HOH   A O   1 
HETATM 2300 O O   . HOH   D 4 .   ? 7.784     -31.440   -20.926   1.000 56.31336 ? 691 HOH   A O   1 
HETATM 2301 O O   . HOH   D 4 .   ? -1.62300  0.12600   -11.18700 1.000 51.39608 ? 692 HOH   A O   1 
HETATM 2302 O O   . HOH   D 4 .   ? 2.05200   -30.37700 -18.63900 1.000 53.06007 ? 693 HOH   A O   1 
HETATM 2303 O O   . HOH   D 4 .   ? -8.66800  -9.16700  -26.55400 1.000 48.07613 ? 694 HOH   A O   1 
HETATM 2304 O O   . HOH   D 4 .   ? 0.49000   1.34500   -10.32400 1.000 51.87553 ? 695 HOH   A O   1 
HETATM 2305 O O   . HOH   D 4 .   ? 4.037     -28.273   -36.278   1.000 56.26865 ? 696 HOH   A O   1 
HETATM 2306 O O   . HOH   D 4 .   ? -2.35200  1.20600   -34.84600 1.000 50.16767 ? 697 HOH   A O   1 
HETATM 2307 O O   . HOH   D 4 .   ? 15.86600  -27.85900 -27.19800 1.000 57.98973 ? 698 HOH   A O   1 
HETATM 2308 O O   . HOH   D 4 .   ? -11.58300 -10.96000 -6.78000  1.000 54.51367 ? 699 HOH   A O   1 
HETATM 2309 O O   . HOH   D 4 .   ? 6.900     -30.617   -23.384   1.000 61.60240 ? 700 HOH   A O   1 
HETATM 2310 O O   . HOH   D 4 .   ? 1.29700   0.90200   -7.73300  1.000 62.39615 ? 701 HOH   A O   1 
HETATM 2311 O O   . HOH   E 4 .   ? 19.18400  -1.98200  -15.38800 1.000 50.28723 ? 201 HOH   B O   1 
# 
